bluuebunny/crossref_metadata_2025 huggingface dataset:
Emotion Detection Based on EEG Signal Processing by Body Sensor 5G Networks Using Deep Learning Architectures
Authors: Mansouri Sofiene , Chabchoub Souhir
Published: December 2022

Emotion recognition is the automatic detection of a person’s emotional state through his or her non-physiological or physiological signals. The EEG-related technique was an effectual system, which is typically employed for recognizing feelings in real time. Artificial Intelligence (AI) can be a developing research field which had rapid growth particularly to constitute a bridge between technology and its implementation in solving real-time issues particularly those relevant to the healthcare domain. This study develops a new deep learning-based emotion detection based on EEG signal processing, named DLED-EEGSP technique. The presented DLED-EEGSP technique identifies the distinct kinds of emotions based on the sensors and EEG signals. To perform this, the presented DLED-EEGSP technique exploits multi-head attention based long short-term memory (MHA-LSTM) method for emotion recognition. The MHALSTM model recognizes the emotion states based on the higher order cross feature samples. The experimental result analysis of the DLED-EEGSP technique is investigated on a series of data. A wide-ranging simulation results reported the supremacy of the DLED-EEGSP technique over other existing models.
Hemostatic system in patients with endometrial hyperplasia and the risk of venous thrombosis: А literature review
Authors: Ozolinya Lyudmila A. , Anikeeva Angelina A.
Published: December 2022

While treating patients with endometrial hyperplasia, the physician may face both bleeding and thrombotic complications, particularly, during hormonal or surgical treatment, which significantly increases the risk of these complications. In addition, thrombotic complications in gynecological patients may result from congenital or acquired thrombophilia, blood flow disorders (blood stasis), and vascular wall damage, that is, the classic Virchow triad.
This study aimed to review the recent scientific literature on the peculiarities of the blood coagulation system in patients with endometrial hyperplasia.
The review reflects the results of studies conducted by Russian and foreign authors on the status of the blood coagulation system in patients with endometrial hyperplasia. The features of vascular, thrombocytic, plasma (procoagulant and anticoagulant), and fibrinolytic elements of hemostasis in these patients are considered. The data from the literature on the state of hemostasis before treatment and following hormone therapy and surgical treatment are presented. Moreover, the data of some studies on the genetic features of the hemostatic system in patients with endometrial hyperplasia are summarized. An analysis of the literature indicates the need for a careful choice of drugs and methods of treatment of these patients to avoid venous thromboembolic complications.
Morphological features of the endometrium in patients with atrophic chronic endometritis and impaired hemodynamics
Authors: Gazizova Gulnaz Kh. , Yashchuk Alfiya G. , Maslennikov Anton V. , Dautova Liliana A. , Battalova Gyuzel’ Yu.
Published: December 2022

BACKGROUND: Chronic endometritis is a clinical and morphological syndrome in which, due to persistent endometrial damage to the endometrium by an infectious agent, multiple secondary morphofunctional changes occur that impair cyclic transformation and receptivity of the uterine mucosa.
AIM: This study aimed to reveal morphological features of the endometrium in patients with atrophic chronic endometritis and impaired hemodynamics in the endometrium.
MATERIALS AND METHODS: The study involved 86 female patients divided into two groups. Group 1 comprised 44 patients with chronic endometritis and impaired endometrial hemodynamics. Group 2 included 42 patients with chronic endometritis without impaired microcirculation in the endometrium. The patients underwent endometrial pipelle biopsy for histological and immunohistochemical examination to determine the expression of VEGF, TGF- and CD138 during the proliferative phase of the menstrual cycle.
RESULTS: Histological examination revealed vascular sclerosis, plasma cells, inflammatory infiltrates, stromal fibrosis, granulomas, and hemorrhagic foci in patients with atrophic chronic endometritis and impaired hemodynamics.
CONCLUSIONS: While examining the morphological picture of atrophic chronic endometritis with impaired hemodynamics, the formation of scar tissue was noted resulting in impaired blood circulation, which leads to focal hemorrhages in the uterine mucosa. According to immunohistochemical analysis, patients with impaired endometrial hemodynamics showed a statistically significant decrease in VEGF and an increase in TGF- expression, which indicates the severity of fibrosis.
2022 Esc Guidelines for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: What is New?
Authors: Novikova Tatiana N. , Novikov Vladimir I. , Sayganov Sergey A. , Shcherbakova Vladislava A.
Published: December 2022

The review presents new indications to help with diagnosis and treatment of ventricular arrhythmia (VA) in patients with various etiologies of rhythm disturbances, including patients with coronary artery disease, cardiomyopathies, channelopathies, inflammatory heart disease, neuromuscular disease, and congenital heart defects. Algorithms for diagnostic evaluation at first presentation with VAs in patients without known cardiac disease are given.
Incidence of Coronary Embolism in Group of Patients with Atrial Fibrillation and Myocardial Infarction
Authors: Soloveva Mariia V. , Boldueva Svetlana A.
Published: December 2022

Embolic myocardial infarction (EMI) is more common than gets to be diagnosed. EMI is often associated with atrial fibrillation (AF). The incidence of this pathology, prognosis and treatment tactics remain unclear.
AIM: To assess the incidence of EMI among patients with myocardial infarction (MI), genesis of coronary embolism (CE), initial characteristics, treatment and prognosis in group of patients with EMI.
MATERIALS AND METHODS: The group of patients with EMI was selected among 1989 patients with MI admitted to the cardiology department of the North-Western State Medical University named after I.I. Mechnikov between 2013 to December 2019. The CE verification criteria were the SUITA criteria. Statistical data processing was carried out using the SAS program.
RESULTS: 16 cases of EMI were registered (0.8% of all MI and 4.3% of patients with MI and AF). 68.7% (95% CI = 41.5%88.9%) of patients with EMI had AF. All patients with EMI and AF did not have adequate anticoagulant therapy before admission. Among patients with EMI, men predominated, they were younger, had fewer comorbidities than patients with MI and without AF. 13 of 16 patients with EMI were prescribed anticoagulants. During hospitalization, the composite endpoint (pulmonary embolism + stroke + cardiovascular death) was recorded in 25% (95% CI = 7.3%52.2%), in the long-term period in 30% of cases (95 % CI = 6.765.2). All these patients had AF. EMI in patients with AF was associated with the development of severe chronic heart failure (CHF) by the time of discharge and with decompensation of CHF in the long-term period.
CONCLUSIONS: EMI often occur in group of patients with AF, always in the absence of adequate anticoagulant therapy. Patients with EMI and AF have a worse prognosis due to recurrent thromboembolic events.
Keywords: anticoagulants; atrial fibrillation; coronary embolism; embolic myocardial infarction; prognosis; thrombaspiration.
Application of the IR spectrometry method in the screening study of various oat species
Authors: Khoreva Valentina I. , Popov Vitaliy S. , Kon'kova Nina G.
Published: December 2022

BACKGROUND: The infrared reflection spectroscopy application method for rapid assessment of biochemical parameters in various types of oats is shown. On the basis of the biochemical data obtained in the laboratory of VIR, calibration models of protein, oil and starch content were constructed.
AIM: The aim of the study is to develop an express method of near-infrared spectroscopy (NIRS) spectroscopy to determine the main biochemical parameters in oat seeds and to build calibration models for the MATRIX-I IR analyser to quantify the mass fraction of protein, oil and starch in oat seeds based on data obtained by traditional methods.
MATERIALS AND METHODS: Biochemical quality indicators (protein, oil, starch) were studied on seeds of filmy oats (Avena sativa L.) grown in 20152016 in the North-Western Region of the Russian Federation. Calibration models for the determination of protein, oil and starch in oat seeds (98 samples, harvest 20142015) were developed for the MATRIX-I IR analyzer by Bruker Optics (Germany). Values obtained by traditional chemical methods of analysis were used to construct calibration models. Oat seed oil was determined by the Soxlet method, protein by the Kjeldahl method, starch by the Evers polarimetric method. All indicators were recalculated for dry weight.
RESULTS AND CONCLUSION: The reliability of the developed models was checked by the results of protein, oil and starch determination in the seeds of the test batch according to the indicator of the calibration correctness. The data obtained using the calibration curve on the MATRIX-I device had no significant differences with the results of chemical studies. Therefore, calibration can be used for screening analysis for protein, oil and starch content in oat samples. This method allows you to save valuable material, increase labour productivity due to the speed of obtaining data, does not require reagents and is safe.
Chronic dust bronchitis: composition of the sputum bacterial microbiome and its association with chromosome damage in blood lymphocytes
Authors: Druzhinin Vladimir G. , Baranova Elizaveta D. , Demenkov Pavel S. , Matskova Lyudmila V. , Paradnikova Snezhana A. , Volobaev Valentin P. , Larionov Alexei V.
Published: December 2022

BACKGROUND: Recent studies show that the bacterial microbiome of the respiratory tract can influence the development of a number of diseases of the human respiratory system. Changes in the composition of the microbiome in patients are associated with dysbiosis, and in addition, many bacteria have a genotoxic potential and can directly or indirectly damage the genome in the cells of the host organism.
AIM: The aim of the study was to analyze the composition of the sputum microbiome and its relationship with chromosome damage in the blood leukocytes of patients with chronic dust bronchitis (CDB).
MATERIALS AND METHODS: The taxonomic composition of the sputum microbiome of 22 patients with CKD and 22 sputum donors from the control group was studied using next-generation sequencing (NGS) technology of 16S rRNA of bacterial genes. At the same time, the basic frequencies of chromosomal aberrations and micronuclei were determined in blood leukocytes.
RESULTS: The sputum microbiome of chronic dust bronchitis patients had a significant reduction in alpha and beta diversity parameters compared to healthy study participants. In addition, an increase in the relative abundance of the genus Streptococcus (29.97 3.03 vs. 18.78 2.47; p = 0.003) was found in the sputum of CP patients compared with the control. Thus, the results of metagenome sequencing indicate a common dysbiotic process with a predominance of one dominant genus of bacteria in this pulmonary pathology. The results of cytogenetic analysis of blood leukocytes showed a significant increase in the proportion of aberrant metaphases in CKD patients compared with healthy donors (3.41% vs. 1.84%; p 0.01) and the absence of significant differences in frequency leukocytes with micronuclei between the compared groups (1.28% vs. 1.11%). Correlation analysis revealed the presence of significant direct relationships between the frequency of aberrant metaphases and the percentage of representatives of the genera Bacteroides in the sputum of patients with chronic dust bronchitis (r = 0.471; p = 0.031); Lachnoanaerobaculum (r = 0.446; p = 0.043) and Alloprevotella (r = 0.444; p = 0.044). Further studies should be devoted to the search for possible mechanisms of influence of these bacteria on clastogenic effects in the cells of the host organism.
Generalized tetanus: a case report
Authors: Shakhmardanov Murad Z. , Nikiforov Vladimir V. , Skryabina Anna A. , Burova Svetlana V. , Tomilin Yuri N. , Abusueva Aida S. , Antipyat Natalya A.
Published: December 2022

Tetanus is a rare disease caused by Clostridium tetani, causing damage to the central nervous system with the development of muscle hypertension and attacks of generalized seizures caused by the action of the pathogenic toxin. Despite the availability of safe and effective vaccines, the urgency of the problem of tetanus incidence is high because a significant part of the population is not immunized against this disease, and severe manifestations of tetanus can be fatal.
This paper presents a clinical case of traumatic generalized tetanus in an 11-year-old patient. The absence of routine immunization against tetanus and emergency activepassive immunization contributed to disease development. The disease proceeded in a typical form, with the development of muscle spasms, myoclonia, trism, and convulsions. Specific tetanus serum was administered, pathogenetic therapy with anticonvulsants and muscle relaxants was performed, and the patient had clinical recovery and was discharged from the hospital.
The impact of natural factors on the condition of roads in various regions of Russia
Authors: Alekseev Sergey  V. , Simonov Dmitry  L. , Katikova Arina  S.
Published: December 2022

The article is devoted to the peculiarities of taking into account natural and climatic conditions when designing a highway. It is shown that environmental conditions directly affect the specifics of the designed roads. However, they can play a dual role: both to promote and counteract the long service life of the roadbed. Since it is impossible to influence the weather conditions, it is necessary to provide full protection of the highway. All factors affecting the road condition at the early stages of design were analyzed. It is concluded that if the regulatory and technical requirements are not met, the quality and safety of the road will not be ensured for each road and climate area.in this regard, the most effective methods of protecting and reducing the negative effects of environmental impact were considered.
The influence of rolling stock indicators on the car component of the freight railway tarif (by the example of gondel cars)
Authors: Egorov Yuriy V.
Published: December 2022

Background: understanding of the indicators affecting the car component of the freight railway tariff is important for the development and implementation of a competent tariff policy for freight railway transport, especially in the context of sanctions restrictions implemented by third countries. Aim: identification and classification of rolling stock indicators that affect the value of the car component of the freight railway tariff, followed by a quantitative assessment of such an impact. Methods: statistical method, econometric modeling, analysis, comparative method, system method. Results: the indicators of the rolling stock that affect the value of the car component of the freight railway tariff are identified, a classification of these indicators is developed according to the criterion of applicability of the monetary meter, an econometric quantitative assessment of the influence of the identified indicators on the car component of the freight railway tariff is made, conclusions are drawn on the sensitivity of the latter to various time lags of the indicators under consideration. Conclusion: the results obtained can be used to improve the tariff policy for freight rail transport, as well as to further develop the theoretical foundations in this area.
Influence of cooling conditions of HTS assembly on the characteristics of a moving maglev system
Authors: Martirosian Irina V. , Osipov Maxim A. , Starikovskii Alexander S. , Pokrovskii Sergey V. , Rudnev Igor A.
Published: December 2022

Background: analysis of the influence of cooling conditions of high-temperature superconducting elements on the power characteristics of a maglev system under conditions of rapidly changing magnetic fields
Aim: analysis of the influence of cooling conditions of high-temperature superconducting elements on the force characteristics of a magnetic-levitation transport platform under conditions of rapidly changing magnetic fields caused by the inhomogeneity of the magnetic track.
Methods: numerical analysis of the maglev system was performed by the finite element method in the Comsol Multiphysics engineering simulation software.
Results: at fast, more than 5 T/s, magnetic field change rates, due to the motion of the superconductor in a magnetic field with a non-uniform local distribution, the preferred method of cooling is the use of cryocooler technology. At rates of change of the magnetic field less than 5 T/s, it is permissible to use liquid nitrogen as a cooler.
Conclusion: The developed numerical model makes it possible to predict the dynamic characteristics of levitation systems of various scales and can be applied to contactless transport, as well as in rotating machines, including kinetic energy storage devices.
Experimental study of the mixing process of asphalt concrete mixtures
Authors: Vasilev Kirill A. , Averchenko Gleb A.
Published: December 2022

The process of mixing mineral components with organic binders in the technology of preparation of hot asphalt concrete mixtures is considered. As a working hypothesis, the assumption of a functional relationship between the power consumption of the electric motor of the agitator and the mixing resistance is accepted. It is necessary to establish the dependence of the power consumption of the agitator drive on various technological parameters. Experiments were carried out: in laboratory and production conditions, which showed fairly simple dependencies.
Resonance versus Shape of Sedimentary Basins
Authors: Castellaro Silvia , Musinu Giuseppe
Published: December 2022

Sediment-filled basins are of interest both in exploration geophysics and in earthquake seismology in assessing their potential to amplify ground shaking. By means of numerical models, we present a number of dimensionless ratios between the main resonance frequencies that can be measured on the top of the basins and their geometry and mechanical properties, under the hypothesis of rigid bedrock. These resonance frequency ratios depend largely on the aspect ratio of the basins, whereas the mechanical properties of the sediments (specifically, the Poisson’s coefficient) do not substantially affect the horizontal resonance frequency ratios. We discuss whether the modal frequencies measured on real basins can be used to extract information about the basins themselves and whether the theoretical expected modal sequence can be used to design experimental surveys aimed at assessing the dynamic behavior of basins.
Efecto de la edad relativa en la natación española
Authors: Martín-Consuegra Sofía , Hernández Martínez Andrea , Gutiérrez Díaz del Campo David , Sánchez-Matas Yolanda
Published: December 2022

El efecto de la edad relativa se refiere a las diferencias cronológicas de sujetos pertenecientes a un mismo grupo de edad, que puede provocar que los nacidos en los primeros meses del año parezcan más talentosos. El objetivo de este estudio fue analizar la posible existencia del efecto de la edad relativa en la natación española. Para llevarlo a cabo se consideraron los 100 mejores resultados en piscina de 50 metros de las últimas seis temporadas (2015-2021), para todas las edades de las categorías con campeonatos nacionales, en ambos sexos y en los cuatro estilos. El análisis se realizó sobre 28.373 resultados obtenidos de la base de datos de la Real Federación Española de Natación, tomando como referencia las fechas de nacimiento de los nadadores. Para identificar si existe el efecto de la edad relativa en la natación en España se aplicó el odds ratio y la prueba estadística chi cuadrado. Así, para calcular las posibles diferencias entre los rendimientos medios entre los trimestres de nacimiento de los nadadores, se realizó́ un análisis de varianza. Los resultados mostraron una distribución desigual de las fechas de nacimiento por trimestres y unos rendimientos medios diferentes para casi todos los grupos de edad, en ambos géneros. En conclusión, se puede decir que la sobrerrepresentación de deportistas en los primeros trimestres del año, y la diferencia en cuanto al éxito deportivo alcanzado, son dos efectos de la edad relativa a considerar.
Patina con Sonic: Efectos de un entorno de aprendizaje gamificado basado en el videojuego Sonic en una muestra de adolescentes en clase de Educación Física
Authors: Carrera Moreno Daniel
Published: December 2022

La inclusión de las competencias en el currículo exige a su vez que los centros educativos y sus docentes apuesten por el uso de metodologías activas que direccionen el proceso de enseñanza-aprendizaje del alumnado. El estudio que aquí se presenta tiene como fin analizar los efectos de un entorno de aprendizaje gamificado basado en el videojuego Sonic en una muestra de adolescentes en clase de Educación Física. Se trata de un estudio no experimental, descriptivo y longitudinal, que muestra la propuesta de una unidad gamificada basada en el mundo de Sonic. Para valorar al proceso de aprendizaje se utilizan dos fichas de registro de anillos y un diario de clase. Los resultados desvelan la gran implicación y motivación del alumnado y buenos resultados de aprendizaje en relación a los objetivos didácticos de la unidad. Se concluye que esta experiencia es una propuesta idónea y motivante para ser utilizada con adolescentes en el contenido de patines en línea. Así mismo, esperamos que esta experiencia sirva de inspiración a otros docentes para continuar innovando y gamificando en Educación Física.
Практические рекомендации по лекарственному лечению дерматологических реакций у пациентов, получающих противоопухолевую лекарственную терапию
Authors: Королева И. А. , Болотина Л. В. , Гладков О. А. , Горбунова В. А. , Когония Л. М. , Круглова Л. С. , Манзюк Л. В. , Орлова Е. В. , Орлова Р. В.
Published: December 2022

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Практические рекомендации по лечению пограничных опухолей яичников
Authors: Давыдова И. Ю. , Валиев Р. К. , Карселадзе А. И. , Ашрафян Л. А. , Новикова Е. Г. , Урманчеева А. Ф.
Published: December 2022

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Практические рекомендации по лекарственному лечению немелкоклеточного рака легкого
Authors: Лактионов К. К. , Артамонова Е. В. , Бредер В. В. , Горбунова В. А. , Демидова И. А. , Деньгина Н. В. , Моисеенко Ф. В. , Проценко С. А. , Реутова Е. В. , Сакаева Д. Д. , Смолин А. В. , Строяковский Д. Л. , Тер-Ованесов М. Д. , Черных М. В.
Published: December 2022

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Клинические рекомендации по коррекции гепатотоксичности, индуцированной противоопухолевой терапией
Authors: Ткаченко П. Е. , Ивашкин В. Т. , Маевская М. В.
Published: December 2022

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ESG (ÇEVRESEL, SOSYAL VE KURUMSAL YÖNETİM) SKORUNUN FİRMA PERFORMANSINA ETKİSİ: TÜRK BANKACILIK SEKTÖRÜ ÖRNEĞİ
Authors: ÇETENAK Emin Hüseyin , ERSOY Ersan , IŞIK Özcan
Published: December 2022

ESG skorları, firmaların çevresel, sosyal ve kurumsal yönetim alanlarındaki yatırım ve faaliyetleri ile ilgili
performansını ortaya koyan bir ölçüttür. Son yıllarda firmaların paydaşlardan gelen talepleri dikkate
alarak çeşitli raporlama modelleri geliştirmesi sonucunda ortaya çıkan bu kavram, tüm paydaşların
finansal kararları üzerinde daha fazla belirleyici olmaya başlamıştır. Bu çalışmanın amacı Türkiye’de faaliyet gösteren mevduat bankalarında ESG skorlarının finansal performans üzerindeki etkisini araştırmaktır. Çalışma 2010-2020 dönemini kapsamaktadır. PCSE ve FGLS panel veri tahmincileri kullanarak yapılan analizlerde, bankaların toplam ESG, sosyal (SPS) ve kurumsal yönetim (GPS)
skorlarının muhasebe ve piyasa temelli performans göstergelerini (ROA ve Tobin Q) pozitif yönde
etkilediği tespit edilmiştir. Diğer taraftan çevresel (EPS) skorunun her iki performans göstergesi üzerinde de istatistiksel olarak anlamlı bir etkiye sahip olmadığı görülmüştür. Ayrıca sonuçlar, Covid-19 pandemisinin bankaların ROA ve Tobin Q ile ölçülen performanslarında azalışa yol açtığını
göstermektedir. Analiz bulguları firma performansını artırmada finansal olmayan raporlamaya ve ESG
faaliyetlerine daha fazla önem verilmesi gerektiğini işaret etmektedir.
The prediction of SARS-CoV-2 main protease inhibition with filtering by position of ligand
Authors: Ivanova Ya.O. , Voronina A.I. , Skvortsov V.S.
Published: December 2022

The paper analyzes a set of equations that adequately predict the IC50 value for SARS-CoV-2 main protease inhibitors. The training set was obtained using filtering by criteria independent of prediction of target value. It included 76 compounds, and the test set included nine compounds. We used the values of energy contributions obtained in the calculation of the change of the free energy of complex by MMGBSA method and a number of characteristics of the physical and chemical properties of the inhibitors as independent variables. It is sufficient to use only seven independent variables without loss of prediction quality (Q² = 0.79; R²prediction = 0.89). The maximum error in this case does not exceed 0.92 lg(IC50) units with a full range of observed values from 1.26 to 4.95.
Business Intelligence for Reducing NPA in Indian Banking Sector
Authors: A. Joshi, , A. Aslekar,
Published: December 2022

Indian Banking sector is a blend of Private as well as public sector banks. In the Economy of a Nation, banks keep a deposit with themselves and interest the depositors. The banks are responsible for the majority of the lending operations that took place in the economy. However, since 2008, the returns on Indian banks’ assets are continuously falling. A healthy banking system is the backbone of a healthy economy. Hence, to help banks make wiser decisions about creating fruitful assets in the future, the paper advises Business Intelligence to help decision-makers make sound decisions and ultimately prevent productive assets in the future.This paper is an attempt to use the Business Intelligence tools to predict if the loan application will turn stressed or not. The outcome of this paper will be on suggesting parameters for the Indian Banks to judge an assetto-be about its fruitfulness so that the NPAs of these banks will be reduced in the future.
Analysis of the Economic Potential of Bangka Belitung Islamic Boarding Schools
Authors: Ilyas Rahmat , Hartono Rudi
Published: December 2022

Pondok Pesantren, the oldest traditional Islamic education institution, grows independently and develops among Muslims in Indonesia. The existence of pesantren has an important role as a pioneer in the spread of Islamic teachings in Indonesia. Islamic boarding schools have three main functions that are always carried out: First, as a center for the regeneration of religious thinkers. Second, as an institution that produces human resource cadres. Third, as an institution that has the power to empower the community. This study aims to analyze the economic potential of Islamic boarding schools, especially in Bangka Belitung. This research uses quantitative methods. The total population in this study was 34 Islamic boarding schools. The data used in this study were primary data. The data were collected through a questionnaire and then went through validity, reliability, and classical assumption tests. The results of this study indicate that the business potential of Islamic boarding schools in Bangka Belitung is very good. This can be seen from the research results showing that 91.18% have business potential, while those who do not have potential are 2.94%, and those with no sure business potential are 5.88%. Human resources (HR) potential in Islamic boarding schools are very good. This can be seen from the educational background, which reaches 74% for undergraduate, 3% for diploma III, and 23% are still at the elementary and high school level.
An audit of prescriptions in general medicine outpatient department in a tertiary care government hospital in Eastern India: a quality improvement project
Authors: . Luv , . Ravikirti , Biswas Ratnadeep , Ojha Vishnu S.
Published: December 2022

Background: Prescriptions are an important link between physicians and patients. Any medication therapy can become ineffective if not communicated properly to the pharmacist and patient. Therefore, it’s important to maintain the quality of prescription-writing. Thus, we conducted a prescription audit in a tertiary-care hospital.Methods: 413 prescriptions having 1683 drugs were selected by convenience sampling. Adherence to 4 quality parameters, namely mention of date, allergy status, date of next visit, and whether or not the prescription was signed legibly, were observed for each prescription. 5 parameters viz. whether or not the drug was written in capital letters, whether the generic name of the drug was mentioned, and prescription of drug schedule, dose, and duration were evaluated for each drug separately. Frequency tables and appropriate bar plots were created.Results: Dates were mentioned in all prescriptions. There were 4.07±0.44 (mean±SD) drugs per prescription. Using capital letters and generic names was observed for 12% and 21% of the drugs. Dose, duration, and schedule were written for 51.4%, 98.6% & 98.7% drugs respectively. The next visit was mentioned in 61.7% cases. 21.8% prescriptions were signed legibly and only 0.5% prescriptions had allergy status.Conclusions: A significant scope of improvement was observed in signing the prescription legibly, mentioning next visit, using generic names, writing the drug names in capital letters, drug doses, and mentioning allergy status. Conducting regular audit-feedback-audit loops will improve the quality of health care delivery in a practical manner.
Learner’s perspectives on competency-based medical education in pharmacology at a tertiary care teaching hospital in South India
Authors: Chakraborty Ananya , A. Meharban , Kamath Latha
Published: December 2022

Background: Competency based medical education (CBME) was implemented recently in India. The study was conducted to evaluate the perspectives of undergraduate medical students towards CBME curriculum in pharmacology at a tertiary care medical college in South India.Methods: After the completion of the curriculum, feedback was taken in a semi-structured, validated questionnaire. It was based on Kirkpatrik’s level 1 model of evaluation. Majority of the questions were framed on a 5-point Likert's scale (1 being poor to 5 being excellent). Qualitative data was collected by open ended question on additional comments.Results: The response rate was 72.8%. Majority of the participants rated the theory classes, practical classes, small group discussions, self-directed learning, integration, and assessments as good and excellent. More than 80% participants rated role play as an innovative and worthwhile concept towards mastering prescription communication. They felt that role play ignites team work, and provides confidence. Close to 90% of the participants rated the overview on emergency use authorization, orientation on drug regulators, perspectives on hydroxychloroquine prophylaxis as effective and excellent. More than 85% participants felt that AETCOM provided them insight on ethical issues, patient communication, and perspective of doctors as caregivers. 9.8% (16) participants provided comments to open ended question for feedback.Conclusions: The study provided an insight of medical undergraduates towards CBME curriculum. Further studies can be designed to look into the effectiveness of teaching learning methods based on the performance of the students, perspective of faculties with focus faculty development, and role of various stakeholders.
Evaluation of knowledge, attitude and practice towards drug-drug interactions among postgraduates in tertiary care hospital, Kurnool
Authors: Sahayaraj Christina , Begum Shaik Haseena , M. Venugopal Reddy , S. Sharon Sonia , Y. Vijaya Bhaskara Reddy
Published: December 2022

Background: Drug-drug interactions (DDIs) are changes in a drug’s effects due to concurrent use of another drug. Clinically significant interactions lead to undesired adverse effects, therapeutic failure, toxicity or may even cause death of the patients. The Aim is to evaluate the Knowledge, Attitude and Practice of Postgraduates regarding DDIs and implementation of educational program may enhance patient’s safety.Methods: A cross-sectional study was conducted among postgraduates in all clinical departments of Government general hospital, Kurnool in the month of October 2021. Pre-validated questionnaire was used to assess the KAP. It contains demographic data, knowledge and practice questions related to DDIs and attitude towards the preferable sources of drug interaction information. Data analysis was done by using SPSS version 26.Results: Out of 220 questionnaires distributed, 126 postgraduates submitted with complete answers(n=126). Overall response rate is 57%. By using the Bloom’s cut-off points, most of the respondents (43.5%) had low level of knowledge towards DDIs. Even respondents with high knowledge level (19%) are not practicing the drug interaction screening during the admission of patients. Majority of PGs with low level knowledge agreed to ask doctors than pharmacist about DDIs and prefer to search for DDIs using reference book than online mode as the source of drug information.Conclusions: In my study, most of the respondents had insufficient knowledge to prevent life threatening DDI’s. So, there is a need to increase medical educational program regarding the importance of screening and assessing of DDI’s before prescribing medicines.
A clinical pharmacological experimental research analysis of the evidence-based rational pharmacotherapeutics of pefloxacin and newer quinolones
Authors: Hazra Moumita
Published: December 2022

Background: Pefloxacin is a newer broad-spectrum bactericidal fluoroquinolone antibiotic, with superior antibacterial activity in vivo against pathogenic ocular gram-negative and anaerobic microorganisms and better pharmacokinetic properties.Methods: 100 bacterial conjunctivitis patients were prescribed topical pefloxacin 0.3% ophthalmological drops monotherapy, 2 drops in each eye after every 3 hours for 2 days, and 2 drops in each eye after every 6 hours for next 5 days. The overall recovery of the patients was clinically examined and assessed. The patients who did not recover completely with 0.3% pefloxacin monotherapy ophthalmological drops, were administered topical pefloxacin 0.3% ophthalmological drops, 2 drops in each eye after every 6 hours for the next 3 days, as combination therapy, with other required ophthalmological eye drops, depending on the prognostic follow-up, on days 0, 3, 5, 7, 10, 15, 30, and on further follow-ups. The evidence-based rational pharmacotherapeutic patient percentage topical application requirements of 0.3% pefloxacin ophthalmological drops monotherapy and subsequent combination therapy for complete recovery from bacterial conjunctivitis was thoroughly analysed and assessed.Results: In this study, the patient percentage topical application requirements of pefloxacin 0.3% ophthalmological drops monotherapy and combination therapy in bacterial conjunctivitis patients showed that 93% patients had completely recovered with pefloxacin monotherapy, and 7% patients required pefloxacin combination therapy for complete recovery. The evidence-based rational pharmacotherapeutics of newer quinolones, in global multi-centre tertiary care hospitals, was also well characterized and analytically described.Conclusions: Therefore, 93% patients had completely recovered with the ocular antibiotic pefloxacin 0.3% ophthalmological drops monotherapy, and 7% patients required pefloxacin combination therapy for complete recovery. The evidence-based rational pharmacotherapeutics of newer quinolones was also distinctly delineated.
The role of honey in the treatment of type 2 diabetes mellitus: a review of literature
Authors: Ofor Casimir C. , Erejuwa Omotayo O. , Akuodor Godwin C. , Aja Daniel O. , Mba Anthony U. , Shu Elvis N.
Published: December 2022

The use of honey in the control of hyperglycemia in patients with type 2 diabetes mellitus is a current option being explored globally. Honey bees which are named in Latin as Apis, use the collected nectar from plants to produce honey after regurgitation and digestion of nectar. Carbohydrate constitutes about 80% of the components of honey. It includes monosaccharides [fructose (37.5%) and glucose (30.6%), disaccharides (sucrose (1.6%) and maltose (2.7%)] and oligosaccharides. Natural honey also contains water (17.2%), proteins, vitamins, minerals, enzymes, acids such as flavonoids, phenolic acids and other components. Honey is rich in antioxidant content and these antioxidant compounds function as endogenous cellular antioxidant defences against free radicals in diabetes mellitus. Antioxidants have also been shown to exert a beneficial effects on blood glucose. Fructose and other bioactive constituents of honey have also been linked with amelioration of hyperglycemia. Besides the beneficial effects of honey on blood glucose, honey is widely used in the management of diabetic foot ulcers, an important complication of diabetes mellitus. The wound-healing benefits of honey are attributed to its antioxidant constituents and broad-spectrum antimicrobial activity. Though additional studies are needed, the use of honey in the management of diabetes mellitus holds much promise.
A comparative cross-sectional study on evaluation of carotid artery intima-media thickness in patients of psoriasis vulgaris: an early predictor of subclinical atherosclerosis
Authors: Kannan Rajkumar , Daniel Samuel J. , Ashraf A. Mohideen , A. Ramesh , Kumar Parimalam , Priya B. Yuva
Published: December 2022

Background: Psoriasis is associated with atherosclerosis and increased cardiovascular risk. Carotid artery intima-media thickness (CIMT) is used as a non-invasive marker in the assessment of subclinical atherosclerosis. In this study, by using a doppler ultra-sonogram, subclinical atherosclerosis in patients with psoriasis was evaluated in need of special follow-up to reduce cardiovascular morbidity. It was aimed to evaluate the mean CIMT, determine the prevalence of subclinical atherosclerosis and to evaluate the association between the severity, duration of psoriasis and CIMT.

Methods: A hospital-based cross-sectional study was done on 25 patients with psoriasis and age, gender, and body mass index (BMI) matched 25 healthy controls over 2 months. CIMT was measured using a doppler ultra-sonogram.

Results: Compared to the controls, patients had higher CIMT. 24% of patients had subclinical atherosclerosis compared to 12% of controls. Chronic smokers with psoriasis had a significant association with subclinical atherosclerosis. Because of the COVID-19 pandemic, it was unable to determine the severity and prognosis of subclinical atherosclerosis through follow up.

Conclusions: This study provides an insight into the higher prevalence of subclinical atherosclerosis in psoriasis patients, smokers in particular. CIMT can serve as an important noninvasive marker to assess cardiovascular risk.
Clinico-epidemiological study of cutaneous adverse drug reactions among the in-patients of dermatology department, Goa Medical College, Goa
Authors: Naik Shubham , Pereira Ian A. , Naik Ravina , Zore Jano
Published: December 2022

Background: An adverse drug reaction (ADR) remains often remains underreported and leads to underestimated cause of morbidity and mortality. ADR frequently manifests as adverse cutaneous drug reactions (ACDRs) and manifestations varies from mild acneiform eruption to life threatening events like toxic epidermal necrolysis. Aim was to study clinic-epidemiological pattern of various ACDRs among inpatients in department of dermatology and study common drugs causing ACDRs and assess causality and severity.

Methods: This retrospective observational study was conducted for a period of one year in department of dermatology in Goa Medical College. All patients fulfilling criteria of study were included.

Results: A total of 24 patients were studied. Most common ACDR was observed in age group of 21-40 years. Stevens Johnson syndrome (SJS) (25%) was most common ACDR followed by morbilliform drug rash (20.8%). Other manifestation was DRESS (12.5%), fixed drug eruption (FDE) (12.5%) and angioedema (12.5%), acute generalized exanthematous pustulosis (AGEP) (8.33%); erythroderma (4.16%) and urticaria (4.16%). Antibiotics were commonly implicated drug category in causation of ACDRs accounting for 37.5% followed by NSAIDS (25%). Based on causality assessment, probable cases had higher incidence - 54.2% followed by possible 37.5%. All patients were considered to have severe reaction as patients required hospitalization for management of adverse reactions.

Conclusions: ADRs are under-reported due to various factors and practicing doctors should be encouraged to report ACDRs in order to improve medical therapy for the benefit of healthcare workers and patients worldwide.
Malignant pilomatrixoma case report: what kind of treatment is the most suitable?
Authors: Emeršič Luka , Stritar Albin , Jurčić Vesna
Published: December 2022

Malignant pilomatrixoma is a rare malignancy with just 136 cases reported in the English literature. The tumour is described as locally aggressive, with possibility of reoccurrence and distal metastasis. Histology remains the gold standard in diagnostic. Wide surgical excision is preferred to simple excision. In the present study a case of first malignant pilomatrixoma in our hospital is described. We made an excision of the tumour and the tissue was sent on histopathology. The skin defect was covered with a local ulnar flap. Through our case report and literature review we focus on the most suitable treatment option. The tumour was not excised with appropriate safety surgical margin based on the histopathology report. Patient refused another excision and any additional treatments. The most optimal treatment has not yet been established. Most of the article’s state that primary wide surgical excision should be done, with surgical margins still being debateable. The best results were given when using Mohs micrographic surgery.
The Fikih Difabel of Muhammadiyah: context, content, and aspiration to an inclusive Islam
Authors: Maftuhin Arif , Muflihati Abidah
Published: December 2022

Since ratifying the CRPD (Convention on the Rights of Persons with disabilities), Indonesia has witnessed developments in promoting the rights of people with disabilities. Public policies and civil organizations make their respective contributions. Muhammadiyah responded favorably by issuing a comprehensive fatwa on Islam and disability in 2020, compiled in Fikih Difabel. This paper uses an interdisciplinary approach to understand the Fikih Difabel. It explores the historical context of disability in Muhammadiyah and analyzes religious interpretations that become the paradigm and content of Fikih Difabel. Data were collected from various primary sources, such as interviews, observations, and analyses of various Muhammadiyah documents. The research concludes that Fikih Difabel is an organizational and academic effort to find a theological basis to promote disability rights. Fikih Difabel has succeeded in listening to the disabled’s aspirations, integrating the national legal norms and current academic findings, and highlighting Islamic ideals of just and inclusive religion. Fikih Difabel is Muhammadiyah’s contribution to promoting Islam as an inclusive and friendly religion for persons with disabilities
Conceptualizing Muslim identity in the US, post-9/11
Authors: Dellarosa Maretha
Published: December 2022

This article examines the conception of Muslim identity by Muslim teachers in the broader Islamophobic American social environment and the ways they support young Muslim children. To answer these questions, this article employs a qualitative case study by observing and interviewing Muslim teachers who teach kindergarteners in a Sunday school program. Drawing on identity, social identity, and intersectionality as theoretical frameworks, the findings from this study demonstrate that the interpretation of good Muslim and Islamic principles serve as an instrument to conceptualize Muslim teachers’ identity.
Incorporating Open Educational Practices in Graduate Education: A Collaborative Autoethnographic Study
Authors: Ives Cindy , Perry Beth , Walsh Pamela
Published: December 2022

In this paper we describe the early steps of our journey through a collaborative autoethnographic research project and share preliminary findings. As distance educators who work at an open, online university, we embrace a philosophy of openness, drawing on open educational practices to facilitate collaborative and flexible learning. As faculty members who support masters and doctoral students, we conceptualize our virtual learning environments as spaces where reciprocal learning takes place between and among learners and professors in a form of co-mentorship. We chose collaborative autoethnography because it is an approach that allows us to interrogate our practice using experiences, archival data, and artifacts as accessible and reliable sources of information. Collaborative autoethnography, which permits us to both individually and collectively critique our practice, requires us to consider our personal experiences in relation to our identities as distance educators within the cultural context of an open and online research university in Canada. The initial data analysis process has uncovered three emergent themes to date. These themes include values linking open educational practices with student engagement and facilitating effective open educational practice through learning design. This research project enables us to experience the power of collaborative autoethnography as a research approach and to further our understanding of the potential of open educational practices in graduate education.
Digital Platforms and Algorithmic Erasure: What are the Implications?
Authors: Madland Colin , Ofosuhene Maxwell
Published: December 2022

As technology advances, people of colour often fall victim to algorithm racial bias. This paper focuses on the problem of digital tools that misidentify, fail to recognize, or erase people of colour. On a spectrum, these issues can range from the annoyance of making people of colour invisible during online meetings, to the endangerment of falsely identifying people of colour of crimes that they did not commit. We encountered the former challenge in September 2020, during a faculty Zoom meeting. Our Zoom erasure experience and subsequent Twitter crop experience raised questions for our investigation: why do people of colour experience erasure on zoom and other digital platforms? Is this problem new? What are the outcomes of our experience? How could the problem be fixed? How is it that biases in technology seem to emulate those found in social life? In this paper we aim to raise awareness through sharing our experience and recommending the interrogation of algorithmic tools released for market, the creation of government policy and laws to hold software companies accountable, and the education about biases for IT professionals, educators, and students in the field.