bluuebunny/crossref_metadata_2025 huggingface dataset:
Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia
Authors: Leitner Dominique F. , Kanshin Evgeny , Askenazi Manor , Siu Yik , Friedman Daniel , Devore Sasha , Jones Drew , Ueberheide Beatrix , Wisniewski Thomas , Devinsky Orrin
Published: May 2022

Background

Tuberous sclerosis complex (TSC) and some focal cortical dysplasias (FCDs) are associated with dysfunctional mTOR signaling, resulting in increased cell growth and ribosomal S6 protein phosphorylation (phospho-S6). mTOR inhibitors can reduce TSC tumor growth and seizure frequency, and preclinical FCD studies indicate seizure suppression. This pilot study evaluated safety of mTOR inhibitor everolimus in treatment resistant (failure of >2 anti-seizure medications) TSC and FCD patients undergoing surgical resection and to assess mTOR signaling and molecular pathways.

Methods and findings

We evaluated everolimus in 14 treatment resistant epilepsy patients undergoing surgical resection (4.5 mg/m2 daily for 7 days; n = 4 Active, mean age 18.3 years, range 4–26; n = 10, Control, mean age 13.1, range 3–45). Everolimus was well tolerated. Mean plasma everolimus in Active participants were in target range (12.4 ng/ml). Brain phospho-S6 was similar in Active and Control participants with a lower trend in Active participants, with Ser235/236 1.19-fold (p = 0.67) and Ser240/244 1.15-fold lower (p = 0.66). Histologically, Ser235/236 was 1.56-fold (p = 0.37) and Ser240/244 was 5.55-fold lower (p = 0.22). Brain proteomics identified 11 proteins at <15% false discovery rate associated with coagulation system (p = 1.45x10-9) and acute phase response (p = 1.23x10-6) activation. A weighted gene correlation network analysis (WGCNA) of brain proteomics and phospho-S6 identified 5 significant modules. Higher phospho-S6 correlated negatively with cellular respiration and synaptic transmission and positively with organophosphate metabolic process, nuclear mRNA catabolic process, and neuron ensheathment. Brain metabolomics identified 14 increased features in Active participants, including N-acetylaspartylglutamic acid. Plasma proteomics and cytokine analyses revealed no differences.

Conclusions

Short-term everolimus before epilepsy surgery in TSC and FCD resulted in no adverse events and trending lower mTOR signaling (phospho-S6). Future studies should evaluate implications of our findings, including coagulation system activation and everolimus efficacy in FCD, in larger studies with long-term treatment to better understand molecular and clinical effects.

Clinical trials registration

ClinicalTrials.gov NCT02451696.
Evaluating the performance of the Pain Interference Index and the Short Form McGill Pain Questionnaire among Chilean injured working adults
Authors: Velez Juan Carlos , Friedman Lauren E. , Barbosa Clarita , Castillo Jessica , Juvinao-Quintero Diana L. , Williams Michelle A. , Gelaye Bizu
Published: May 2022

Background

Chronic pain can lead to economic instability, decreased job productivity, and poor mental health. Therefore, reliable identification and quantification of chronic pain is important for clinical diagnosis and treatment.

Objective

To determine the psychometric properties of the Spanish language versions of the Pain Interference Index (PII) and the Short Form McGill Pain Questionnaire (SF-MPG) among a population of working adults who experienced injury in Santiago, Chile.

Methods

A total of 1,975 participants with work-related injuries were interviewed to collect sociodemographic, occupational, and chronic pain characteristics. Construct validity and factorial structure of the PII and SF-MPG were assessed through exploratory factor analyses (EFA). Cronbach’s alpha was used to evaluate internal consistency.

Results

The PII mean score was 3.84 ± 1.43 among all participants. The SF-MPG median score was 11 [IQR: 6–16] in this study population. Cronbach’s alpha for the PII was 0.90 and 0.87 for the SF-MP. EFA resulted in a one factor solution for the PII. A two-factor solution was found for the SF-MPG. The two-factors for SF-MPG were sensory and affective subscales with Cronbach’s alpha of 0.82 and 0.714, respectively. When the two scales were combined, an EFA analysis confirmed the PII and SF-MPG measure different aspects of chronic pain.

Conclusions

The PII and SF-MPG had good construct validity and reliability for assessing different aspects of chronic pain among working Chilean adults.
Experimental study on the desorption effect of penetrant on gas-containing coal
Authors: Zhao Dan , Liu Baichen , Liu Zhongxin , Wang Chunguang , Su Weiwei , Shen Zhiyuan
Published: May 2022

Two non-ionic reagents, polyethylene glycol 4000 and Tween-80, two anionic reagents, sodium dodecyl benzenesulfonate and sodium lauryl sulfate, and a mixture of these non-ionic and anionic reagents were used as penetrants. The processes of replacement desorption and relief-pressure desorption of gas-containing coal were studied, the influence of the penetrant on the amount of gas replacement desorption and relief-pressure desorption was explored, and the change rule of the amounts of gas replacement desorption and relief-pressure desorption was analysed. The results show that the increase rate of the replacement desorption amount of the mixed penetrant is 11.81%-34.75%, and the decrease rate of the relief-pressure desorption amount is 51.68%-72.69%, which are higher values than those with a single penetrant. As the mass fraction of penetrant increases within the range of 0.5%~2%, the capacity of gas replacement desorption and hindering gas relief-pressure desorption will increase. At the same mass fraction, the effect of the mixed penetrant is better than that of the anionic penetrant, which in turn is better than that of the non-ionic penetrant.
Association of hypertension with helicobacter pylori: A systematic review and meta‑analysis
Authors: Fang Yizhen , Xie Huabin , Fan Chunming
Published: May 2022

Background and aims

The number of hypertensive population rises year by year recently, and their age becomes more youthful. For a long time, hypertension has long been regarded as a multi-factorial disease. In addition to smoking, genetics, diet and other factors, helicobacter pylori (H. pylori) had been regarded as a potential risk factor for hypertension in recent years. However, most studies had certain limitations and their results were inconsistent. Thus, it is necessary for us to assess the impact of H. pylori on hypertension through meta-analysis.

Methods

We searched all published relevant literature through multiple databases by July 23, 2021. Pooled results were calculated under the random effect model. Heterogeneity was evaluated by the Q statistic and the I2 statistic. The risk of bias was evaluated via ROBINS-I tool. Publication bias was evaluated by the Egger test and Begg funnel plot.

Results

6 eligible studies involving 11317 hypertensive patients and 12765 controls were selected from 20767 retrieval records. Our research confirmed that H. pylori significantly increased the probability of suffering from hypertension in the random effect model (OR:1.34, 95% CI:1.10–1.63, P = 0.002, I2 = 74%). The same results were also found in both Asian population and developing country (OR:1.28, 95%CI:1.05–1.55, P = 0.003, I2 = 78.5%).

Conclusions

Our results confirmed that H. pylori was a vital risk factor for hypertension. H. pylori-infected people were 13.4% higher risk for hypertension than uninfected individuals. In addition, it will be a new method to prevent and treat hypertension by eradicating H. pylori.

Trial registration

The registration number for systematic review in PROSPERO CRD42021279677.
Perturbation-based trunk stabilization training in elite rowers: A pilot study
Authors: Schäfer Robin , Schäfer Hendrik , Platen Petra
Published: May 2022

Introduction

Low back pain is a major health issue in elite rowers. High training volume, frequent flexion movements of the lower spine and rotational movement in sweep rowing contribute to increased spinal strain and neuropathological patterns. Perturbation-based trunk stabilization training (PTT) may be effective to treat neuromuscular deficits and low back pain.

Methods

All boat classes (8+, 4+/-, 2-) of the male German national sweep rowing team participated in this non-randomized parallel group study. We included 26 athletes (PTT: n = 12, control group: n = 14) in our analysis. Physical and Sports therapists conducted 16 individualized PTT sessions á 30–40 minutes in 10 weeks, while the control group kept the usual routines. We collected data before and after intervention on back pain intensity and disability, maximum isometric trunk extension and flexion, jump height and postural sway of single-leg stance.

Results

We found less disability (5.3 points, 95% CI [0.4, 10.1], g = 0.42) for PTT compared to control. Pain intensity decreased similar in both groups (-14.4 and -15.4 points), yielding an inconclusive between-group effect (95% CI [-16.3, 14.3]). Postural sway, strength and jump height tend to have no between- and within-group effects.

Conclusion

Perturbation-based trunk stabilization training is possibly effective to improve the physical function of the lower back in elite rowers.
Prevalence, incidence, morbidity and mortality rates of COPD in Saudi Arabia: Trends in burden of COPD from 1990 to 2019
Authors: Alqahtani Jaber S.
Published: May 2022

Background

The available data to determine the chronic obstructive pulmonary disease (COPD) burden in Saudi Arabia are scarce. Therefore, this study closely examines and tracks the trends of the COPD burden in Saudi Arabia from 1990 to 2019 using the dataset of the Global Burden of Disease (GBD) 2019.

Methods

This study used the GBD 2019 dataset to analyse the COPD prevalence, incidence, morbidity and mortality rates in the Saudi Arabian population from 1990 to 2019, stratified by sex and age. The age-standardised rate was used to determine the prevalence, incidence, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life years (DALYs) and deaths.

Results

In 2019, an estimated 434,560.64 people (95% Uncertainty Interval (UI) 396,011.72–473,596.71) had COPD in Saudi Arabia, corresponding to an increase of 329.82% compared with the number of diagnosed people in 1990 [101,104.05 (95% UI 91,334.4–111,223.91)]. The prevalence rate of COPD increased by 49%, from 1,381.26 (1,285.35–1,484.96) cases per 100,000 in 1990 to 2,053.04 (1918.06–2194.29) cases per 100,000 in 2019, and this trend was higher in males than females. The incidence rate of COPD in 2019 was 145.06 (136.62–154.76) new cases per 100,000, representing an increase of 43.4% from the 1990 incidence rate [101.18 (95.27–107.86)]. In 2019, the DALYs rate was 508.15 (95% UI 434.85–581.58) per 100,000 population. This was higher in males than females, with a 14.12% increase among males. In 2019, YLLs contributed to 63.6% of DALYs due to COPD. The death rate due to COPD was 19.6 (95% UI 15.94–23.39) deaths per 100 000 in 2019, indicating a decrease of 41.44% compared with the death rate in 1990 [33.55 deaths per 100 000 (95% UI 25.13–47.69)]. In 2019, COPD deaths accounted for 1.65% (1.39–1.88) of the total of deaths in Saudi Arabia and 57% of all deaths caused by chronic respiratory diseases.

Conclusion

Over the period 1990–2019, the prevalence and incidence of COPD in Saudi Arabia have been steadily rising. Even though COPD morbidity and death rates have been decreasing, they remain higher in men and older age. The holistic assessment and interventions with careful attention to optimising the community-based primary care management, such as screening for early diagnosis, smoking cessation programs and pulmonary rehabilitation, are likely to be the most successful strategies to reduce the burden of COPD in Saudi Arabia.
Ecological divergence of wild birds drives avian influenza spillover and global spread
Authors: Hill Nichola J. , Bishop Mary Anne , Trovão Nídia S. , Ineson Katherine M. , Schaefer Anne L. , Puryear Wendy B. , Zhou Katherine , Foss Alexa D. , Clark Daniel E. , MacKenzie Kenneth G. , Gass Jonathon D. , Borkenhagen Laura K. , Hall Jeffrey S. , Runstadler Jonathan A.
Published: May 2022

The diversity of influenza A viruses (IAV) is primarily hosted by two highly divergent avian orders: Anseriformes (ducks, swans and geese) and Charadriiformes (gulls, terns and shorebirds). Studies of IAV have historically focused on Anseriformes, specifically dabbling ducks, overlooking the diversity of hosts in nature, including gull and goose species that have successfully adapted to human habitats. This study sought to address this imbalance by characterizing spillover dynamics and global transmission patterns of IAV over 10 years at greater taxonomic resolution than previously considered. Furthermore, the circulation of viral subtypes in birds that are either host-adapted (low pathogenic H13, H16) or host-generalist (highly pathogenic avian influenza—HPAI H5) provided a unique opportunity to test and extend models of viral evolution. Using Bayesian phylodynamic modelling we uncovered a complex transmission network that relied on ecologically divergent bird hosts. The generalist subtype, HPAI H5 was driven largely by wild geese and swans that acted as a source for wild ducks, gulls, land birds, and domestic geese. Gulls were responsible for moving HPAI H5 more rapidly than any other host, a finding that may reflect their long-distance, pelagic movements and their immuno-naïve status against this subtype. Wild ducks, long viewed as primary hosts for spillover, occupied an optimal space for viral transmission, contributing to geographic expansion and rapid dispersal of HPAI H5. Evidence of inter-hemispheric dispersal via both the Pacific and Atlantic Rims was detected, supporting surveillance at high latitudes along continental margins to achieve early detection. Both neutral (geographic expansion) and non-neutral (antigenic selection) evolutionary processes were found to shape subtype evolution which manifested as unique geographic hotspots for each subtype at the global scale. This study reveals how a diversity of avian hosts contribute to viral spread and spillover with the potential to improve surveillance in an era of rapid global change.
The Drama Therapy Decision Tree: Connecting Drama Therapy Interventions to Treatment, Paige Dickinson and Sally Bailey (2021)
Authors: Trottier Dana George
Published: May 2022

Review of: The Drama Therapy Decision Tree: Connecting Drama Therapy Interventions to Treatment, Paige Dickinson and Sally Bailey (2021)Bristol: Intellect Ltd, 272 pp.,ISBN 978-1-78938-247-1, h/bk, $106.50ISBN 978-1-78938-249-5, e/bk, $80.00
Design approach for cost-effective hybrid CLT floors
Authors: Lakusic Stjepan
Published: May 2022

There is a growing research and production interest for the application of lower-cost hybrid cross-laminated timber (CLT) panels composed of timber layers of dissimilar quality. Therefore, an approach for the design of cost-effective hybrid CLT panels in bending, based on the existing analytical and novel finite element procedures, is presented in the paper. The gamma-method, the extended gamma method, and the composite theory are applied in the analysis of square panels, while the finite element model based on the Reddy’s full layerwise theory is used for the complex-shape panels in bending. An extensive benchmark technical and economic study is performed for 25 CLT panels, considering various spans, lamination schemes, geometries, and boundary conditions. Cost savings made by using a lower timber class in central zones of CLT panels are highlighted and quantified. This concept shows an economic potential that should be considered during the design and production of CLT panels in structural engineering applications, such as lightweight floor structures.
Urea(lly) Got Me: An Uncommon Etiology of Peripartum Liver Failure
Authors: Spiller Robert E. , Colombo Christopher J. , Lindholm Phillip C. , Kwon James
Published: May 2022

A 23-year-old woman presented 4 days postpartum for agitation and confusion, with initial evaluation consistent with acute fatty liver of pregnancy (AFLP). Later in her course, an amino acid panel was highly suggestive of citrullinemia type 1. She was started on arginine supplementation and glycerol phenylbutyrate and evaluated for a liver transplant. After starting the medication and diet modification, her liver failure resolved, and she was safely discharged. Urea cycle disorders may mimic AFLP with liver enzyme elevation, delirium, and hyperammonemia, but unlike AFLP, patients with urea cycle disorders will typically not recover without dietary modifications and/or medication.
Entrevista com William Palin
Authors: Palin William , Giannini Marcelo , Braga Roberto R.
Published: May 2022

William Palin é Professor Titular do Biomedical Materials Science e Diretor de Pesquisa da Faculdade de Odontologia do Institute of Clinical Sciences, Universidade de Birmingham, Reino Unido. Sua principal experiência está no desenvolvimento de novos biomateriais, como tecnologias para regeneração óssea, materiais restauradores e equipamentos, incluindo fontes de luz e fibras ópticas para fototerapia, aparelhos fotoativadores odontológicos e materiais médicos terapêuticos. Recentemente, desenvolveu um programa de mestrado de pós-graduação em Ciência de Materiais Dentários, que é um programa educacional ministrado por especialistas mundiais que fornece treinamento em pesquisa para o uso de equipamentos de última geração. É chefe da especialidade de ensino de Ciência dos Materiais Dentários para estudantes de graduação em Odontologia, técnicos de higiene dental e terapeutas. Atualmente, é editor do European Journal of Prosthodontics and Restorative Dentistry, editor da área de Adesão de Biomateriais do International Journal of Adhesion and Adhesives e editor associado do Photobiomodulation and Laser Surgery. Ainda, é membro do corpo editorial das revistas científicas Dental Materials, Journal of Dentistry e Dental Materials Journal. Atua, também, como responsável pelas premiações da Academia de Materiais Dentários.
O impacto dos materiais e técnicas na longevidade das restaurações, as incertezas científicas e a necessidade de focarmos na saúde
Authors: Hilgert Leandro Augusto
Published: May 2022

“Professor, qual sistema adesivo é o melhor?”. “Técnica incremental ou bulk fill?”. “Restauração direta ou indireta?”. “Qual o material forrador que devo usar em cavidades profundas?”. Acredito que muitos já receberam perguntas como essas ao terminar uma aula, uma palestra ou até no direct, após compartilhar um caso nas redes sociais. Provavelmente, quem pergunta acredita e espera que, ao utilizar os mesmos materiais e técnicas, obterá resultados semelhantes àqueles vistos e admirados na apresentação ou publicação. Seguindo a lógica de que professores e formadores de opinião (e, quiçá, todos os profissionais da Odontologia) deveriam embasar suas atitudes e recomendações nas evidências científicas de mais alta qualidade disponíveis, reflito sobre o quão difícil é responder a tais questionamentos, sem que seja dada apenas uma opinião, uma preferência pessoal ou um relato de experiência (que, cientificamente falando, não são tão relevantes). Por outro lado, ao mostrar dentes hígidos, sem lesões cariosas, não cariosas ou qualquer tipo de restauração na boca de um paciente de quarenta e poucos anos — algo hoje, felizmente, nada incomum —, não vejo a mesma curiosidade por parte do público. Quase ninguém pergunta qual a estratégia de promoção de saúde utilizada, qual rotina de manutenção/retorno, quais os comportamentos desse paciente, seguramente bem orientado e acompanhado por seu dentista, que levaram a esse quadro tão positivo. É, de certa forma, triste ver que alguns admiram mais o dentista que restaura, restaura e restaura (“Lindas restaurações, parecem dentes!”), do que aquele que, competentemente, trata seus pacientes, reduzindo seu risco de apresentarem progressão de lesões e, assim, mantém saudáveis e funcionais os dentes de verdade.
Instagram Nu e Cru
Authors: Ottoboni Thiago
Published: May 2022

Para os colegas recém-formados, a Odontologia tem tomado dois caminhos: um caminho mais árduo, lento, sólido, no qual o cirurgião-dentista não perde sua essência de promover saúde e restabelecer estética aliada à função, com ética e respeito; e outro, mais fácil, rápido, cheio de atalhos, buscando rapidamente fama e/ou dinheiro, no qual se vende a ideia de que todo paciente se torna “facetável” e que esse tratamento é rápido, fácil, reversível e minimamente invasivo. Pense no que quer para seu futuro; a Odontologia e nossos pacientes merecem o melhor.
Alterações dimensionais do osso alveolar propriamente dito após elevação de retalho: um estudo pré-clínico
Authors: Sukekava Flávia , Lima Luiz Antonio Pugliese Alves de , Araújo Mauricio
Published: May 2022

Objetivo: O objetivo do presente estudo foi descrever as características do osso alveolar propriamente dito (OAPD) e sua resposta frente à cirurgia a retalho, pois há poucas informações científicas disponíveis na literatura a respeito das dimensões do OAPD. Métodos: Cinco cães foram incluídos no estudo. Em um dos lados da maxila (GT), uma incisão intrassulcular foi feita no sulco gengival da face vestibular do segundo e terceiro pré-molares, e um retalho total foi elevado, permitindo a exposição do osso alveolar. Após 15 minutos, os retalhos foram retornados à sua posição original e suturados com suturas simples. No lado contralateral (GC), nenhum tratamento foi executado. Após três meses de cicatrização, biópsias contendo dentes e seus tecidos periodontais foram obtidas e preparadas para análise histológica. Resultados: As análises histológicas demonstraram que, no GC, o OAPD exibiu pequena variação de espessura ao longo de toda sua porção coronal na face vestibular. Também foi observado que, no GT, ocorreu uma perda substancial de osso 1 mm abaixo da junção cemento-esmalte (JCE). Não houve diferença estatisticamente significativa entre os grupos para as dimensões do OAPD aos 3 e 5 mm abaixo da JCE. Conclusão: Esses resultados sugerem que a espessura do OAPD foi relativamente constante e que a cirurgia a retalho promoveu perda de tecido duro na sua porção mais coronal.
Restauração Endocrown: uma alternativa para espaço interoclusal reduzido
Authors: Carvalho Adriana Oliveira , Souza Alana Pinto Caroso , Costa Monise Naula Souza , Silva Aliana Carneiro Nery , Martins Ângela Guimarães Nery , Vieira Alex Correia
Published: May 2022

Introdução: Dentes extensamente destruídos tratados endodonticamente podem ser reconstruídos por meio de diferentes técnicas restauradoras, como as restaurações Endocrown, as quais têm como objetivo devolver a forma, função e resistência mecânica a forças mastigatórias. Relato de caso: O presente trabalho relata um caso clínico de reabilitação de um molar extensamente destruído, com espaço interoclusal reduzido, por meio da técnica de restauração Endocrown. O tratamento foi realizado nas seguintes etapas: cirurgia periodontal prévia de aumento de coroa clínica, para restabelecimento do espaço biológico; coroa provisória; preparo dental; moldagem, confecção e cimentação da restauração indireta. Conclusão: A técnica restauradora utilizada mostrou-se eficaz e satisfatória na reconstrução dentária, devolvendo estética e função para um dente com pouco remanescente coronário e espaço interoclusal reduzido.
Desarrollo de la metacognición al resolver problemas de adición de números enteros
Authors: Acosta Barros Carlos , Bravo Castro Roberto , Campo Torné Alberto , Fontalvo Yaruro Maisi
Published: May 2022

La literatura muestra que los estudiantes, y las personas en general, que practican la metacognición, tienen mayor capacidad para planificar, supervisar y evaluar sus tareas intelectuales. La presente investigación ? en la cual se usaron técnicas cualitativas mediante un diseño de estudio de caso ? se centra en el desarrollo de las habilidades de metacognición para resolver problemas de adición de números enteros en una estudiante. Los resultados muestran que en el diagnóstico la participante no mostró habilidades específicas acerca de los componentes de la metacognición, pero luego se encontró — en general ? que la sujeto utilizó progresivamente los componentes metacognitivos ante los problemas planteados. En conclusión, se mostró la forma en que la metacognición incide positivamente en la participante, al desarrollar la capacidad para autorregular su propio aprendizaje. Igualmente, se observó transferencia –sobre todo en el seguimiento de las tareas— a unas nuevas experiencias o situaciones de aprendizaje.
La lectura: una marca de ciudadanía
Authors: Herrera Delgans Miguel Ángel
Published: May 2022

Este artículo es una reflexión teórica sobre las relaciones que se pueden establecer entre la lectura como proceso complejo de la significación humana y la ciudad como constructo humano que supera los límites de lo urbanístico. La ciudad moderna debe gran parte de su esencia a los aportes que la lectura ha permitido, pues ésta ha reestructurado las formas de pensar. Por otro lado se sostiene la idea de que un mejor lector puede constituir una mejor ciudad, y en ese sentido los líderes de las grandes urbes deben cuidar y atender a los sujetos de la ciudad en términos de cómo leen y qué leen.
El ABP mediado con tecnología móvil como estrategia pedagógica para el desarrollo de la competencia matemática en resolución de problemas: un caso con la adición de números enteros negativos
Authors: Dominguez Merlano Eulises , Matos Navas Rodolfo Enrique , Castro Flores Ibeth del Carmen , Molina Padrón Candelaria , Gómez Zúñiga Irma Esther
Published: May 2022

En este artículo se presentan los resultados de la investigación "Efecto del Aprendizaje Basado en Proyectos mediado con tecnología móvil en la resolución de problemas aditivos con números enteros negativos". La investigación es cuantitativa, con enfoque correlacional y diseño cuasiexperimental con pre-test y pos-test. Se conformaron dos grupos, experimental y control, de veinte estudiantes cada uno. El primero utilizó el ABP con la mediación de los Classemate, mientras que el segundo, no empleó la mediación de la tecnología. Para establecer las diferencias entre los grupos, se empleó el método estadístico ANOVA, evidenciando que no existen diferencias significativas en la competencia de resolución de problemas entre los grupos. Sin embargo se determinó que existen diferencias en el pre-test y pos-test al interior de los grupos. La utilización del ABP mejora el desempeño de los estudiantes en la competencia de resolución de problemas independientemente del tipo de mediación empleada.
Desarrollo de la competencia resolución de problemas desde una didáctica con enfoque metacognitivo
Authors: Iriarte Pupo Alberto Jesús
Published: May 2022

En el presente artículo de investigación, se muestra la influencia de la implementación de estrategias didácticas con enfoque metacognitivo en el desarrollo de la competencia resolución de problemas matemáticos en estudiantes de quinto grado de básica primaria. El diseño metodológico utilizado fue cuasi-experimental con cuatro grupos; la intervención se realizó en cuatro fases, poniendo en práctica la instrucción directa, el modelado metacognitivo, la práctica guiada y el aprendizaje cooperativo. Se realizaron comparaciones intragrupos e intergrupos estableciéndose diferencias estadísticas significativas, que corroboraron la efectividad de las estrategias aplicadas.
Niveles de literacidad de los estudiantes de Psicología de la Institución Universitaria de Envigado
Authors: Henao Salazar José Ignacio , Londoño Vásquez David Alberto , Frias Cano Ladis Yuceima , Castañeda Naranjo Luz Stella
Published: May 2022

La investigación "¿Cómo leen y escriben los estudiantes que ingresan a la Facultad de Ciencias Sociales?" realizada en la Institución Universitaria de Envigado, tuvo como objetivo demostrar que un curso orientado desde la lingüística textual y el análisis crítico del discurso potencia la cultura escrita de los estudiantes, que en su mayoría presentan serios problemas de literacidad. Se realizaron dos pruebas a dos grupos: uno experimental, orientado desde la lingüística textual y análisis crítico del discurso, y otro de control, con una orientación más tradicional y formal: la primera para describir el nivel de litera-cidad con que ingresan a la universidad y, la segunda, para describir el nivel con que terminan el semestre. Los resultados demostraron que mientras que el grupo experimental mejoró significativamente la habilidad para resumir y leer críticamente, así como en el manejo de la textualidad, el grupo control permaneció casi en el mismo estado en el que entró.
Huellas de la escritura materna en el español escrito como L2
Authors: Cassany Daniel
Published: May 2022

Siguiendo los Nuevos Estudios de Literacidad2 y utilizando técnicas etnográficas (observación, entrevistas), criticamos varios aspectos de la concepción cognitiva de la “lectura en idioma extranjero” y proponemos una alternativa más sociocultural, que incorpora las particularidades reseñadas, que ofrece una visión más realista y completa y que pone el acento en el alfabetismo crítico. A partir de entrevistas a hablantes competentes del español como L2, que fueron alfabetizados en una lengua materna tipológicamente muy diferente y con un sistema de escritura distinto, exploramos el efecto que tienen las prácticas literarias escolares, en varias culturas, en el aprendizaje del español como segunda lengua.
Características de la escritura en docentes universitarios
Authors: Pertuz Córdoba Wilfran José , Perea Guarnizo Nelsy Rubi , Mercado Peñaloza Mabel Helena
Published: May 2022

El presente artículo es producto de un estudio realizado con el objetivo de identificarlas características discursivas de un grupo de docentes de la Universidad del Norte. La metodología utilizada fue de corte cualitativo con un diseño de Estudio de Caso, en el cual se usaron como técnicas e instrumentos para la recolección y análisis de la información la entrevista semiestructurada y el análisis documental. El sustento teórico del estudio se basó en los postulados de autores como Halliday, Van Dijk, Flower and Hayes, Flavell, Cassany, Teberosky y Castelló, entre otros. Los resultados obtenidos muestran las características de los textos de los docentes que participaron en la investigación, donde se evidencian las estrategias cognitivas y metacognitivas que utilizan al escribir, las dificultades que enfrentan y el tipo de textos que producen.
Gravity and lymphodynamics
Authors: Holm‐Weber Thomas , Kristensen Rasmus Eskild , Mohanakumar Sheyanth , Hjortdal Vibeke E.
Published: May 2022

The lymphatic system is compromised in different groups of patients. To recognize pathology, we must know what is healthy. We use Near‐Infrared Fluorescence (NIRF) to assess peripheral lymphatic function in humans. We have shown that external factors such as exercise, hyperthermia, and pharmacological mediators influence the function of peripheral lymphatic vessels. In this study, we explored the impact on lymphatic vessels by the ever‐present external factor—gravity. We used NIRF imaging to investigate the lymphatic changes to gravity. Gravity was assessed by changing body position from supine to standing. We extracted following lymphatic functional parameters: lymphatic packet propulsion frequency (contractions/min), velocity (cm/s), and pressure (mmHg). Raw data analysis was performed using a custom‐written Labview program. All sequences were analyzed by two observers and interclass correlation scores were calculated. All statistical analysis was performed using RStudio Team (2021). RStudio: Integrated Development Environment for R. RStudio, PBC. Healthy participants (n = 17, 11 males, age 28.1 ± 2.6 years) were included. The lymphatic packet propulsion frequency at baseline was 0.5 ± 0.2 contractions/min and rose within 3 min significantly to a maximum of 1.2 ± 0.5 contractions/min during upright posture and remained significantly higher than the baseline lymphatic packet propulsion frequency after lying down again for up to 6 min. The lymph velocity was 1.5 ± 0.4 cm/s at baseline and changed in both directions and without a specific pattern at different points in time during standing. Lymph pressure was significantly higher while standing (mean increase 9 mmHg, CI: 2–15 mmHg). The ICC scores were 89.8% (85.9%–92.7%), 59.3% (46.6%–69.6%) and 89.4% (79.0%–94.8%) in lymphatic packet propulsion frequency (130 observations), velocity (125 observations), and pressure (30 observations), respectively. The lymphatic system responds within few minutes to gravitational changes by increasing lymphatic packet propulsion frequency and pressure.
The Effects of School Start Time on Educational Outcomes: Evidence from the 9 O’clock Attendance Policy in South Korea
Authors: Kim Taehoon
Published: May 2022

This study estimates the effects of school start time on sleep time, time use, and educational achievement of high school students. Gyeonggi province, the largest province in South Korea, has implemented the 9 O’clock Attendance Policy, which has delayed school start times to 9:00 AM since September 2014. Changes in the above outcomes before and after the policy implementation are compared between Gyeonggi and other provinces which do not implement the policy. The difference-in-differences estimation results show that the policy increases sleep time, and this is mainly from delayed wake-up time. The policy also reduces adolescents’ time use for computer games. The estimation results using administrative national exam data show that the 9 O’clock Attendance Policy does not significantly affect academic achievement.
Corrosion, stress corrosion cracking and corrosion fatigue behavior of magnesium alloy bioimplants
Authors: Das Priyabrata , Kumar T. S. Sampath , Sahu Kisor K. , Gollapudi Srikant
Published: May 2022

The use of magnesium and its alloys as temporary implants has gained interest in the last two decades due to their good mechanical properties and bio-degradability in the in-vivo conditions. However, the issues of higher corrosion rate and stress corrosion cracking persist, which are responsible for the implants’ early failure. This review paper focuses on the challenges involved in the use of magnesium-based implants and the advancements in mitigating the corrosion-related issues for in-vivo use of biodegradable magnesium alloy implants. Herein we review the degradation behavior of three groups of magnesium alloys, i.e., aluminum-containing Mg alloy, rare earth element (REE) containing Mg alloy, and aluminum-free Mg alloy in a variety of testing media. We also review various surface modification techniques such as mechanical methods, physical methods, and chemical methods adopted to address the shortcomings of the Mg alloys. Furthermore, recent developments in Mg based bioimplants such as Mg-based open porous scaffolds, nanostructured Mg alloys and Mg based bulk metallic glasses are reviewed. In the end, recent clinical trials of the Mg-based implant were reported in detail.
Comparative study of estimating the Curie point depth and heat flow using potential magnetic data
Authors: Ibrahim Amin , Saada Saada Ahmed , Mickus Kevin , Abdelrahman Kamal , Khedr Fares Ibrahim
Published: May 2022

The estimation of the Curie point depth (CPD) and heat flow (HF) from magnetic data is useful for geothermal and tectonic studies. However, the methodology of estimating these values is still controversial as numerous studies have used different types of transformed magnetic data. Most studies utilize the total magnetic intensity (TMI) or the reduced to the pole (RTP) data, and since shallow magnetic bodies may affect the final CPD values, low-pass (LP) wavelength filtering has also been used to estimate the CPD. In this study, the two-dimensional radially averaged spectral analysis was applied to the land-based magnetic data from the Sinai Peninsula. TMI and RTP data were both analyzed, using different LP filtered wavelengths, and the final CPD and HF values were compared. The cut-off wavelength parameter was selected in terms of the geologic complexity. The results show that the estimated CPD values are well correlated regardless of whether the magnetic data were either TMI or RTP. The RTP data produced a spatial shift in the CPD smaller than the window size being used. Additionally, the centroid method is primarily dependent on the wavenumber, which varied slightly on applying the RTP. There were slight differences in the estimated CPDs when a short LP filter (e.g., 20 km) was applied, whereas increasing the wavelength (e.g., 40 km) caused the CPD values to increase exceeding the plausible depth limits, and the associated spatial trends varied when compared to the other methods. In areas where the basement rocks were shallow or exposed, a LP filter can be applied with short cut-off wavelength. The estimated CPDs were discussed in the context of seismicity data, gravity-based Moho depths, and HF measurements.
Crystal structure of acrinidinium tetrafluorohydrogenphthalate, C21H11F4NO4
Authors: Liu Xin-Fang , Song Jun-Ya , Zhao Bei-Bei , Huang Shi-Jie
Published: May 2022

C21H11F4NO4, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 9.5000(4) Å, b = 13.9989(7) Å, c = 14.1423(5) Å, α = 91.355(4)°, β = 108.542(4)°, γ = 98.958(4)°, V = 1756.02(14) Å3, Z = 4, R

gt
(F) = 0.0494, wR

ref
(F
2) = 0.1157, T = 293(2) K.
The crystal structure of bis(pyrazolo[1,5-a]pyrimidine-3-carboxylato-κ
2
N,O)-copper(ii), C14H8N6O4Cu
Authors: Hong Dong-Feng , Chen Ye , Zhu Wen-Li
Published: May 2022

C14H8N6O4Cu, monoclinic, C2/c (no. 15), a = 15.6054(8) Å, b = 7.0441(3) Å, c = 12.6301(6) Å, β = 108.550(5)°, V = 1316.24(11) Å3, Z = 4, R

gt
(F) = 0.0317, wR

ref
(F
2) = 0.0778, T = 293 K.
The crystal structure of bis(4-chloro-2-(((2-chloroethyl)imino)methyl)phenolato-κ2
N,O)-oxidovanadium(IV), C18H16Cl4N2O3V
Authors: Wei Wei , Zhang Ya-Zhai , Zhang Heng-Qiang , Zhang Qi-Ying , Xuan Zhao-Kun , Chen Hong-Li
Published: May 2022

C18H16Cl4N2O3V, orthorhombic, Pbca (no. 61), a = 7.8555(3) Å, b = 21.6645(7) Å, c = 23.7584(8) Å, V = 4043.3(2) Å3, Z = 8, R

gt
(F) = 0.0296, wR

ref
(F
2) = 0.0799, T = 296(2) K.
Influences of inter- and intra-row spacing on the growth and head yield of cabbage (Brassica oleracea var. capitata) in western Amhara, Ethiopia
Authors: Tegen Habtamu , Jembere Mnuyelet
Published: May 2022

Plant population of 40,000 ha−1 with the respective inter- and intra-row spacing of 50 cm × 50 cm is the blanket recommendation for the production of head cabbage in Ethiopia. However, producers complain that this spacing produces too large head size, which is not the market's preference for household consumption instead for hotels and big institutions like universities. This two-season field experiment was conducted to optimize the head cabbage yield with appropriate head size by adjusting inter- and intra-row spacing. The result of the combined analysis over location and season revealed that all tested parameters were significantly (P < 0.05) influenced by the interaction effect of inter- and intra-row spacing. The combinations of 35 cm × 30 cm, 35 cm × 50 cm, and 50 cm × 30 cm inter- and intra-row spacing gave the highest head yield of 45, 43 significantly, and 42 t ha−1, respectively as compared to other treatment combinations. The interaction of the lowest inter- and intra-row spacing of 35 cm × 30 cm gave the lowest average head weight of 923 g of cabbage. The result showed that as intra-row spacing increased from 30 to 50 cm with all possible combinations of inter-row spacing, head-sized cabbage increased linearly. The current study identified that blanket recommendation of 50 cm × 50 cm inter-and intra-row spacing which assures a plant population of 40,000 ha−1 produced more than 1.4 kg individual head weight with a yield penalty of 10.70 t ha−1 compared to 50 cm × 30 cm inter- and intra-row spacing combination which assures a plant population of 66,667 ha−1. The current study confirmed that the earlier blanket recommendation of 40,000 plants ha−1 should be enhanced to a plant population of 66,667 ha−1 with a yield advantage of 131%. Concretely the manifested plant population difference gives an opportunity to producers to harvest a maximum yield with an acceptable head size of 1.2 kg. Therefore, it is concluded that the combination of 50 cm × 30 cm inter- and intra-row spacing assures that a plant population of 66,667 ha−1 is optimum for the production of head cabbage in the study and similar agro-ecologies.
Early Neolithic Large Blades from Crno Vrilo (Dalmatia, Croatia): Preliminary Techno-Functional Analysis
Authors: Kačar Sonja , Philibert Sylvie
Published: May 2022

The excavation of Crno Vrilo site (Zadar, Dalmatia, Croatia), carried out by B. Marijanović, has unearthed the vestiges of an Early Neolithic village dating back to ca. 5800–5600 cal BC. The lithic assemblage, with more than 4000 pieces, represents the biggest Impressed Ware assemblage of littoral Croatia. Lithic production at Crno Vrilo is characterised by the pressure Blade flaking on high-quality exogenous cherts (Gargano, southern Italy) reflecting important socio-economic and technical aspects that are specific to the Neolithic. The presence of some débitage elements such as flakes, debris, cortical and technological pieces indicates that standard pressure flaking occured at the site, while the presence of large Blades (with widths exceeding 20 mm) suggests production by lever pressure, a technique that required specialized knowledge and equipment. This article questions whether the lever pressure technique was used in the production of large Blades and examines the status of these Blades in the Crno Vrilo lithic assemblage by examining their technological and functional aspects.
Restoring the Technicolor Ornament
Authors: Chen Phoebe
Published: May 2022

This article analyzes the 1986 restoration of the first successful Technicolor II feature film, The Toll of the Sea (1922), which invoked Madame Butterfly tropes and fantasies of Asiatic femininity to amplify its spectacle of chromatic novelty. Restorers worked to reconstitute the film’s two-color scheme and used an antique beam-splitting Technicolor camera to shoot new footage of the narrative’s definitive suicide, which was missing from the recovered negative. By tracing these two constitutive absences—the initial suicide of the figure I call the “yellow woman” and the remade scenes of her death, voided of her corporeal presence—this article takes up restoration and racialization as analogous processes that reproduce material conditions of visibility. I use this restoration’s epistemic investment in certain forms of continuity and completion—technological, aesthetic, temporal—to examine how film archival practices can perpetuate historical ways of knowing circumscribed by racial and colonial common sense.
Lesbian Bars, Archival Media Bricolage and Research-Creation
Authors: Pidduck Julianne
Published: May 2022

This article reflects on the author’s research-creation project entitled After Hours Chez Madame Arthur as a speculative practice of archival media bricolage. After Hours was a multimedia installation returning to the 1970s lesbian bar Chez Madame Arthur mounted at the Centre Never Apart in summer 2019. Made possible by the support of co-researchers, community groups, technicians, research assistants and artists who share my fascination with local queer women’s history, After Hours restaged this storied bar deploying diverse archival media traces and period objects. This essay discusses some of the possibilities of research-creation and non-representational theory for lesbian, feminist, and queer historical projects. I explore the affordances of archival media traces for forging affective and erotic relationships between past and present, with a particular emphasis on presence, metonymy, storytelling, and space.
Researching as Searching
Authors: Czach Liz
Published: May 2022

In this article, the author recounts her efforts to locate archival materials pertaining to women’s participation in travel-lecture filmmaking. Encountering an archival absence, she refuses this lacuna and speculates that some of these films and their paratexts have survived. Undertaking a form of speculative archival detective work the author summarizes the various clues and avenues she pursued to locate the work of a prominent travel-lecture filmmaking couple. She argues for an understanding of speculative archival work as encompassing not the work a researcher does with extant materials in an archive, but the work of research entailed to bring a collection to an archive.
Towards a Methodology of Unwatched Digital Media
Authors: Berliner Lauren S.
Published: May 2022

Cinema and Media Studies scholarship has historically been grounded in examining media that has been deemed significant. Whether that significance has been determined to be social, aesthetic, political, or even economic, our focus has been trained on understanding and explaining its import. In the age of digital media networks, we now have the added metrics of shares and likes to support our methods of media consumption and engagement, or at the least confirm that there is indeed an active audience. Building from established approaches in the field, this article seeks to bring attention to the digital media landscape to ask, what do digital audiovisual media that have been posted online but do not circulate have to offer? A close textual analysis of several such videos is used to advocate for a methodology to elucidate the themes, identities, and production practices that are escaping (algorithmically informed) representation.
MECHANISMS IN ENDOCRINOLOGY: The pathophysiology of transient congenital hypothyroidism
Authors: Peters Catherine , Schoenmakers Nadia
Published: May 2022

Transient congenital hypothyroidism (TCH) refers to congenital hypothyroidism which spontaneously resolves in the first few months or years of life. Currently, there is a paucity of reliable markers predicting TCH at diagnosis, and the diagnosis is established following the withdrawal of levothyroxine therapy around 3 years of age. The incidence of TCH is increasing, and it is a major contributor to the overall increase in the incidence of CH in recent studies. Both genetic factors, in particular mutations affecting DUOX2 and DUOXA2, and environmental factors, for example, iodine deficiency and excess, anti- TSHR antibodies and exposure to antithyroid or iodine-rich medications, may cause TCH. Resolution of TCH in childhood may reflect both normal thyroid physiology (decreased thyroid hormone biosynthesis requirements after the neonatal period) and clearance or cessation of environmental precipitants. The relative contributions and interactions of genetic and environmental factors to TCH, and the extent to which TCH may be prevented, require evaluation in future population-based studies.