bluuebunny/crossref_metadata_2025 huggingface dataset:
Disrupting Privilege as Power and Control: Re-Imagining Business and the Appreciation of Indigenous Stewardship in Management Education Curricula
Authors: Young-Ferris Anna , Voola Ranjit
Published: October 2022

We explore privilege and its systemic intertwining with management education curricula. We take the view that privilege as power and control is intimately bound up with shareholder primacy as a foundation of mainstream management education (Lund Dean & Forray, 2021). In an attempt to tackle this, we provide a single case study of how we appreciate a broad concept of Indigenous stewardship in a brand-new foundation unit called “Responsible Business Mindset,” as part of a Master of Commerce program at a large Australian university. By proactively engaging with Indigenous stewardship to tackle privilege we contribute to the literature on engaging with privilege in management education curricula. We highlight how a concept of Indigenous stewardship may help us to reimagine business, where business no longer ignores the interconnections and interdependencies it has with the communities and natural environments within which it operates. Such a concept may also be a means to bolster alternative narratives to shareholder primacy that currently exclude a meaningful debate about privilege. At the same time, the entire exercise of introducing a new concept into the curricula has brought about a deep and critical self-reflection of our own privilege and how we as educators can respectfully and meaningfully introduce such concepts with a sense of appreciation rather than appropriation.
Evaluating the Evidence for Fidget Toys in the Classroom
Authors: Kriescher Stephanie L. , Hulac David M. , Ryan Alexandra M. , King Breanna L.
Published: October 2022

Fidget toys have been marketed as universal educational supports in the absence of a scientific evidence base. This article gives an overview of the existing literature on the effect of fidget toy use on student attention, behavior, and learning, and a review of two competing theoretical approaches to fidget toys: sensory processing theory and cognitive load theory. Currently, there is not sufficient support for the implementation of fidget toys in the classroom. Suggestions for best practice when using fidget toys in an educational setting are included.
Using Mixed-Reality Simulation in Teacher Preparation in Reading
Authors: Allen Abigail A. , Stecker Pamela M.
Published: October 2022

Mixed-reality teaching simulations can provide preservice special educators with targeted practice on instructional skills. The last decade of research indicates participation in a simulated classroom produced gains in preservice teachers’ use of evidence-based teaching practices and increased their confidence in working with students with disabilities. This column describes the procedures for using a mixed-reality teaching simulator with preservice special educators teaching a reading lesson to a virtual student avatar. Advantages and considerations for use of the simulator are discussed.
Thai CLEFT-Q: Phase 1—A Pilot Study of Translation and Cultural Adaptation in Thailand
Authors: Chaisrisawadisuk Sarut , Jaruniphakul Kollawat , Tongchenchitt Sigunya , Prathyajuta Jirapat , Liadprathom Kanokwan
Published: October 2022

To translate and culturally adapt the original English version of the CLEFT-Q into Thai (Thai CLEFT-Q).

A pilot study.

A single tertiary referral hospital in Thailand.

Patients with cleft lip or palate (CL/P) aged between 8 and 29 years.

The CLEFT-Q was translated and culturally adapted from English into Thai using the good practice guidelines developed by the International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Two forward translations and reconciliation, 1 back translation, and 2 sets of cognitive debriefing interviews with patients were performed to develop the Thai CLEFT-Q.

The English version of the CLEFT-Q consists of 13 scales (119 items) assessing appearance, health-related quality of life (HRQOL), and facial function. The forward translations revealed 33.6% inconsistencies. They were related to narrow meaning (2.5%) and improper (16.8%) or incorrect (14.3%) wording or phrasing of the items. After reconciliation, the back translation showed 5 inconsistencies (4.2%) with the original version. However, no changes were needed because the reconciliation version was consistent with the source version. Sixteen participants underwent cognitive debriefing interviews, which revealed a comprehensive interpretation of the Thai CLEFT-Q. Interim reports revealed fair facial appearance scores, albeit with HRQOL and facial function outcomes.

Translation and cultural adaptation of the Thai CLEFT-Q provided evidence of its transferability and equivalence with the original English version. Feasible comprehension of the Thai version was also achieved.
The affordances of art for making technologies
Authors: Rietveld Erik
Published: October 2022

With this inaugural lecture as Socrates Professor on the topic of Making Humane Technologies, I aim to show that artistic practices afford embedding technologies better in society. Analyzing artworks made at RAAAF, an art collective that makes visual art and experimental architecture, I will describe three aspects of making practices that may contribute to improving the embedding of technology in society: (1) the skill of working with layers of meaning; (2) the skill of creating material playgrounds that afford free exploration of the potential of new technologies and artistic experiments; and (3) the skill of openness to the possibility of having radically different socio-material practices. I will use images of several RAAAF projects to make these skills involved in making more tangible. It is artistic skills like these that can contribute to a better societal embedding of technologies.
A Meta-Analysis on the Impact of Prenatal and Early Childhood Antimicrobial Use on Autism Spectrum Disorders
Authors: Li Li-guo , Fu Hong-guang , Zhao Yong-hong , Zhao Peng-ju , Meng Qing-kai , Zheng Rui-juan , Li En-yao
Published: October 2022

Objective:

To investigate the impact of prenatal and early childhood antimicrobial use on autism spectrum disorders (ASD).

Data Sources:

We searched PubMed and Embase databases for relevant studies from inception to August 2022.

Study Selection and Data Extraction:

Peer-reviewed, observational studies were all acceptable. Raw data were extracted into a predefined worksheet and quality analysis was performed using the Newcastle–Ottawa Scale.

Data Synthesis:

Nineteen studies were identified in the meta-analysis. Prenatal antimicrobial exposure was not associated with ASD ( P = 0.06 > 0.05), whereas early childhood antimicrobial exposure was associated with an increased odds ratio of ASD (OR = 1.17, 95% CI = [1.08-1.27], P value < 0.001). The sibling-matched analysis, with a very limited sample size, suggested that neither prenatal ( P = 0.47 > 0.05) nor early childhood ( P = 0.13 > 0.05) antimicrobial exposure was associated with ASD. Medical professionals may need to take the possible association into consideration when prescribing an antimicrobial in children.

Conclusions:

Early childhood antimicrobial exposure could increase the incidence of ASD. In future studies, it would be necessary to control for confounding factors, such as genetic factors, parenteral age at birth, or low birthweight, to further validate the association.
Adjunctive Dexmedetomidine in Alcohol Withdrawal Syndrome: A Systematic Review and Meta-analysis of Retrospective Cohort Studies and Randomized Controlled Trials
Authors: Polintan Edgar Theodore T. , Danganan Lester Mico L. , Cruz Nikki S. , Macapagal Sharina C. , Catahay Jesus Alfonso , Patarroyo-Aponte Gabriel , Azmaiparashvili Zurab , Lo Kevin Bryan
Published: October 2022

Objective:

To investigate whether dexmedetomidine (DEX), as adjunctive therapy to benzodiazepine (BZD), is superior to BZD alone in critically ill patients with alcohol withdrawal syndrome (AWS).

Data Sources:

PubMed Central, Cochrane CENTRAL, ClinicalTrials.gov and Google Scholar were used as search databases. Specific keywords and MeSH terms were “dexmedetomidine,” “benzodiazepine,” and “alcohol withdrawal syndrome.” The last search was on September 16, 2022.

Study Selection and Data Extraction:

Randomized controlled trials (RCTs) and nonrandomized/cohort studies exploring the use of DEX in the management of AWS were included. A total of 12 studies were included in the systematic review and 7 in the meta-analysis.

Data Synthesis:

The intensive care unit length of stay (ICU LOS) was found to have a mean difference (MD) of 48.06 [37.48, 58.64], P = <0.001 for the cohort subgroup, significantly favoring the DEX arm, but, in contrast, pooled RCT data showed a result of –20.07 [–36.86, –3.28], P = 0.02, a shorter ICU LOS for the DEX arm. Bradycardia and hypotension incidence significantly favored the BZD arm in both subgroups. This study compares the effectiveness of adjunctive DEX in clinical practice and aims to help providers in critical decision-making by compiling and analyzing the best current available evidence of its use in AWS.

Conclusions:

Based on low to very low level of evidence, adjunctive DEX showed no significant difference for ICU LOS when compared with BZD alone. Pooled randomized trials potentially show a benefit but are similarly limited by their low quality of evidence.
Good Weeds? Alfarabi’s Virtuous Subversives
Authors: Howells Laura , Hawley Michael
Published: October 2022

Why would anyone cultivate weeds? Alfarabi’s The Political Regime prompts this unexpected question. There Alfarabi uses a horticultural metaphor inherited from Plato to describe his ideal regime. His imagined polity is a garden beset by weeds, which threaten to choke the life out of the other plants. Although most of these weeds are to be eradicated for the sake of the garden that is his ideal regime, Alfarabi proposes to cultivate one variety. This kind of weed challenges the official doctrines of the regime. Since the regime is based on false teachings about the universe, such debunking questioning poses a series threat. Yet alfarabi proposes to indulge and encourage the doubts of these weeds. In this paper, we explore the reasons for Alfarabi’s strange treatment of these dissidents. We argue that Alfarabi’s proposal reflects an important disagreement with his teacher, Plato, about the extent to which an ideal model ought to be tethered to reality. Our argument helps to illuminate one of the more perplexing aspects of Alfarabi’s political thought and his relationship with Plato. Most broadly, we show that we will miss important contributions to ideal theory if we fail to appreciate that what constitutes “ideal” may vary widely.
Liver Metastasis of Thymoma: Case Report and Review of the Literature
Authors: Mallick Jayati , Peterson Joshua M. , Pina-Oviedo Sergio , Patel Nekita , Venkatesan Rohit , Stevenson Heather L. , Qiu Suimin , Shen Yuan , Lyapichev Kirill A.
Published: October 2022

The 2021 “World Health Organization (WHO) Classification of Thoracic Tumours” classifies epithelial tumors of the thymus (thymomas) based on cytomorphology. Thymomas with benign cytomorphology are classified as type A, AB, B1, B2, and B3, while those with malignant cytomorphology are classified as thymic carcinoma. Although all thymomas have malignant potential, extra-thoracic metastasis of thymomas is exceedingly rare and the exact incidence is not known. Literature review demonstrated 39 cases of thymoma with extra-thoracic metastases reported since the publication of the 1999 WHO Classification of Thoracic Tumours. Nine of these cases presented with metastasis to the liver in the setting of concurrent metastasis to other organs, while only three cases metastasized solely to the liver. We herein report a well-documented case of type B1 thymoma with relatively limited stage (IIb) with an isolated, single liver metastasis occurring seven years after primary resection in a patient with concomitant myasthenia gravis. The following report includes a review of the literature, a discussion of thymoma classification and its relevance to prognosis, and an overview of other extra-thoracic metastatic thymoma cases.
Treatment of Symptomatic Subfibular Ossicle by Excision and Modified Broström Procedure for Skeletally Immature Patients
Authors: Xiong Shikai , Xie Xing , Shi Weili , Chen Linxin , Jiang Dong , Jiao Chen , Hu Yuelin , Guo Qinwei
Published: October 2022

Background:

Ossicle resection combined with ligament repair using the modified Broström procedure (MBP) is generally associated with favorable results in adults with symptomatic subfibular ossicles; however, the surgical results of this approach in skeletally immature patients remain unclear. The purpose of this study was to investigate the midterm clinical outcomes and radiographic outcomes including leg length and physeal growth of skeletally immature patients after this procedure.

Methods:

Twenty-six consecutive skeletally immature patients who underwent ossicle resection combined with the MBP were retrospectively evaluated. Clinical scores were evaluated using the visual analog scale (VAS), American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score, Karlsson-Peterson score, and Tegner score. The talocrural angle, fibular length on radiographs, and tape-measured leg length between the 2 ankles were also measured at the final follow-up. Time of return to sports and postoperative complications were also evaluated.

Results:

Fourteen girls (53.8%) and 12 boys (46.2%) had surgery at a mean age of 12.7±2.4 years. Mean postoperative follow-up time was 40.0±10.8 months. Mean VAS pain score improved from 4.1 preoperatively to 0.5 at final follow-up ( P < .05). Mean AOFAS score, Karlsson score, and Tegner score all improved from 62.0, 54.0, and 2.8 preoperatively to 95.5, 94.0, and 5.4 ( P < .05), respectively, at final follow-up. Median time of return to sports was 17.0 weeks. Mean talocrural angle, fibular length, and tape-measured leg length of the injured ankle were not significantly different from those of the contra-side at the final follow-up. All patients were satisfied with the results; repeat ligamentous injury occurred in 2 patients (7.7%). We had no cases of wound infection, nerve injury, compartment syndrome, or any other complications.

Conclusion:

Ossicle resection combined with the MBP performed in skeletally immature patients with symptomatic subfibular ossicles resulted in improved clinical outcomes without disruption of fibular physeal growth by an average of 3.3-year follow-up.

Level of Evidence:

Level IV, case series.
Staging mediatized tourism places as imagined playscapes: The crucial role of a tour designer
Authors: Jang Kyungjae , Kim Sangkyun
Published: October 2022

This study examines how a mediatized space becomes a “staged” place to play with, and provides a symbolic platform for performance-based, tourism experiences from a tour program design perspective. It focuses on the Detective Conan Mystery Tour, a derivative tourism product of Detective Conan, a Japanese mystery fiction media franchise. Applying the concept of “playscapes” as the theoretical lens, the findings indicate that creating fiction-driven places forms “imagined playscapes” through the endless negotiation process that occurs between tourists as consumers and tour designers and/or operators as producers. In this regard, tour designers play a crucial role in creating the imagined playscapes of the mediatized spaces, inviting tourist performance as a metaphor for an utterly authentic experience.
2022 AAFP/ISFM Cat Friendly Veterinary Interaction Guidelines: Approach and Handling Techniques
Authors: Rodan Ilona , Dowgray Nathalie , Carney Hazel C , Carozza Ellen , Ellis Sarah LH , Heath Sarah , Niel Lee , St Denis Kelly , Taylor Samantha
Published: October 2022

Practical relevance:

The ‘2022 AAFP/ISFM Cat Friendly Veterinary Interaction Guidelines: Approach and Handling Techniques’ (hereafter the ‘Cat Friendly Veterinary Interaction Guidelines’) support veterinary professionals with feline interactions and handling to reduce the impact of fear and other protective (negative) emotions, in so doing enhancing feline welfare and In implementing these Guidelines, team satisfaction and cat caregiver confidence in the veterinary team will increase as the result of efficient examinations, better experience, more reliable diagnostic testing and improved feline wellbeing. Veterinary professionals will learn the importance of understanding and appropriately responding to the current emotional state of the cat and tailoring each visit to the individual.

Clinical challenges:

Cats have evolved with emotions and behaviors that are necessary for their survival as both a predator and prey species. A clinical setting and the required examinations and procedures to meet their physical health needs can result in behavioral responses to protective emotions. Cat friendly interactions require understanding, interpreting and appropriately responding to cats’ emotional states and giving them a perceived sense of control while performing the required assessment.

Evidence base:

These Guidelines have been created by a Task Force of experts convened by the American Association of Feline Practitioners and the International Society of Feline Medicine, based on an extensive literature review and, where evidence is lacking, the authors’ experience.

Endorsements:

These Guidelines have been endorsed by a number of groups and organizations, as detailed on page 1127 and at catvets.com/interactions and icatcare.org/cat-friendly-guidelines .
Pricing Services: An Underutilized Policy Instrument for Access and Quality
Authors: Barber Sarah L , Ikegami Naoki
Published: October 2022

We aim to introduce the readers of this special collection to the importance of pricing health and long-term care services, a topic covered in 2 recent joint World Health Organization/Organization for Economic Co-operation and Development (WHO/OECD) publications. The special issue will focus on country experiences in pricing setting and regulation, best practices, and areas for future research.
Associations Between Perceptions of e-Cigarette Harmfulness and Addictiveness and the Age of E-Cigarette Initiation Among the Population Assessment of Tobacco and Health (PATH) Youth
Authors: Bluestein Meagan A. , Harrell Melissa B. , Hébert Emily T. , Chen Baojiang , Kuk Arnold E. , Spells Charles E. , Pérez Adriana
Published: October 2022

Introduction

Youth perceptions of harmfulness and addictiveness of e-cigarettes may impact the age that they initiate e-cigarette use, but this has not been investigated previously.

Methods

Youth (12-17 years old) never e-cigarette users at their first wave of PATH participation (waves 1-3, 2013-2016) were included. PATH questions on absolute perceptions of e-cigarette harmfulness and addictiveness were used as exposures. Interval-censored Cox proportional hazards models were used to estimate the impact of perceptions of harmfulness, and perceptions of addictiveness on (i) the age of initiation of e-cigarette use and (ii) age of first reporting past 30-day e-cigarette use, while controlling for covariates.

Results

Youth who perceive e-cigarettes as having no/little harm had increased risk of initiating both ever e-cigarette use (AHR = 2.04; 95%CI = 1.74-2.40) and past 30-day e-cigarette use (AHR = 2.64; 95%CI = 2.07-3.37) at earlier ages compared to youth who perceive e-cigarettes as having a lot of harm. Youth who perceive the likelihood of becoming addicted to e-cigarettes to be very/somewhat unlikely had increased risk of an earlier age of both ever (AHR = 1.28; 95%CI = 1.07-1.52) and past 30-day (AHR = 1.36; 95%CI = 1.04-1.79) e-cigarette initiation compared to youth who perceived the likelihood of becoming addicted to e-cigarettes to be somewhat/very likely.

Conclusion

These results highlight the importance of communicating to youth the potential for health harms and addiction from e-cigarette use in prevention and intervention campaigns, as those with the lowest perceptions of harmfulness and addictiveness had the earliest ages of e-cigarette initiation.
Chasing dön spirits in Tibetan medical encounters: Transcultural affordances and embodied psychiatry in Amdo, Qinghai
Authors: Tidwell Tawni L. , Nianggajia  , Fjeld Heidi E.
Published: October 2022

Although spirit possession is generally considered a psychiatric illness, the class of conditions designated as dön (Tib. gdon, “afflictive external influences,” often glossed as “spirit affliction”) in Tibetan medicine represents a distinctive paradigm for an etiology where physical and mental facets inhere in every illness. This study draws upon ethnographic fieldwork in eastern Tibet to examine two conditions that represent illness presentations at both ends of the dön spectrum: one that maps onto a biomedical etiology of stroke and another that presents in a way similar to schizophrenia. The case studies illuminate the forms of harmful external influences that (1) have physiological and psychological impacts that present as symptoms and (2) contribute to a pathogenesis common to both conditions. Our analysis considers the dual role of cultural affordances and bio-looping in the cultural presentation of the two conditions, as well as how the Tibetan medical tradition draws upon cultural, social, biological, and psychological determinants to understand this class of conditions. We also explore the implications the dön illness category has for biomedically oriented paradigms through the way in which it accounts for cultural models for both diagnosis and treatment of several chronic inflammatory conditions that have significant concomitant mental health presentations.
Hostelquality: A methodology for assessing the quality of hostels
Authors: de Moura Pavão Farias Daniela , Valença Marilia Nunes , Sobral Marcos Felipe Falcão , Bezerra Ribeiro Ana Regina
Published: October 2022

Hostels are an important part of the tourism industry but despite this, many of the metrics used to measure conventional hotels do not apply to the hostel sector. Therefore, this study developed a new methodology called HOSTELQUALITY for the classification of hostels. The method was applied in 10 establishments located in 3 tourist cities in Brazil. The method includes 29 questions in 10 dimensions: environment, leadership, security, cleanliness, location, social atmosphere, equipment, staff, price, and customers. It provides a five-level classification: Deficient, Weak, Average, Good, and Excellent. In addition, it provides graphical output. The results showed that half of the hostels received a good rating. The findings indicate that no establishment achieved a degree of excellence and demonstrated the new methodology’s applicability, providing a consistent and easy-to-interpret classification. This new methodology can be used on specialized websites, by institutions, and by governments to provide supporting information.
The Social Deal: Urban regeneration as an opportunity for In-Place Social Mobility
Authors: Levine Daphna , Aharon-Gutman Meirav
Published: October 2022

Urban regeneration and its implications for issues such as housing, gentrification, and homeownership have been researched by numerous theorists, practitioners, and policy makers. However, this article challenges the perception that urban regeneration is primarily a policy driver that leads to the displacement of residents, and by proposing an investigation of how urban regeneration also constitutes an opportunity for homeowners to achieve ‘In-Place Social Mobility’ (IPSM) – that is, social mobility without leaving their homes and neighborhoods. At a time when the welfare and social service system is weakening, residential property values are increasing, and wages remain stagnant, individuals must turn their homes into investment assets in order to increase their social opportunities. Following the Planning Deal and the Regeneration Deal, the interpretative scheme of the ‘Social Deal’ incorporates two fields: the city as a growth machine, and the social mobility of the homeowners. Through the theoretical demonstration of the notion of IPSM through urban regeneration in Israel, we propose the Social Deal as a new way of understanding the rent gap discussion – i.e., not only as a result of the cultural preferences of consumers on the one hand, or of real estate developers and market supply on the other hand, but also as a means to the self-profit of the residents.
Opening spatial hinges with mindful writing practice: negotiating Philip Pullman’s secret commonwealth
Authors: Lovell Jane
Published: October 2022

This article enquires how ‘spatial hinges’ between author Philip Pullman’s series The Book of Dust and different sites are unexpected and elusive, but may opened by mindfulness. Natalie Goldberg’s mindful writing practice techniques are used as an interpretative instrument to measure this hinging together of parallel worlds. The research data amalgamates interviews with Oxford fantasy tour guides conducted before COVID 19 restrictions with writing sprints about Lockdown walks in both a local park and on a guided tour of ‘Philip Pullman’s Oxford’. The data reveals how a secret commonwealth of elves and fairies infuse the parks with otherworldly, unexpected and exaggerated bucolic awakenings and intersubjectivity, exposing ancient mythical places, including a holloway. On a tour of Oxford, the imaginative storytelling techniques of the guide include impromptu flights of fancy and tilted perspectives that contribute to an atmosphere of unlikeliness, suggestive of Pullman’s texts. In addition, an experience of getting lost or ‘de-touring’, leads to unexpected encounters with the affective mystical presence of Pullman’s novels. The findings conclude that mindfulness may create a state of attunement to the reverberations of the opening of spatial hinges, allowing stories to reveal themselves spontaneously.
Susceptibility of TNFAIP8, TNFAIP8L1, and TNFAIP2 Gene Polymorphisms on Cancer Risk: A Comprehensive Review and Meta-Analysis of Case–Control Studies
Authors: Bhowmik Khokon Kanti , Barek Md Abdul , Aziz Md. Abdul , Islam Mohammad Safiqul
Published: October 2022

Objectives: The TNFAIP8 gene family and TNFAIP2 gene are inextricably linked to an elevated risk of cancer development. This systemic review and meta-analysis seeks to establish the relationship between TNFAIP8 (rs11064, rs1045241, rs1045242, and rs3813308), TNFAIP8L1 (rs1060555), and TNFAIP2 (rs710100 and rs8126) polymorphisms with the risk of cancer. Methods and Materials: A systematic search of multiple databases from January 2022 to April 2022 was used to identify relevant studies. Odds ratios (ORs) with corresponding 95% CI and p-value were calculated to assess the association. Bonferroni correction was performed to correct p-values. Trial sequential analysis (TSA) and in-silico messenger RNA expression were also performed. Review Manager 5.4 software was used for performing this meta-analysis. Results: This study comprised 6909 cancer patients and 7087 healthy participants from 14 studies. Four genetic models of rs11064 (codominant 2 [COD2]: OR = 2.30, p = 7.83 × 10−5; codominant 3 [COD3]: OR = 2.10, p = .0006; recessive model [RM]: OR = 2.24, p = .0001; AC: OR = 1.47, p = .037), two genetic models of rs1045241 (codominant 1 [COD1]: OR = 1.27, p = .009; overdominant model [ODM]: OR = 1.24, p = .018), four genetic models of rs1045242 (COD1: OR = 1.52, p = .005; dominant model (DM): OR = 1.56, p = .002; OD: OR = 1.48, p = .008; AC: OR = 1.48, p = .002), and three genetic models of rs8126 (COD2: OR = 1.41, p = .0005; COD3: OR = 1.44, p = .0002; RM: OR = 1.43, p = .0001) were statistically linked to cancer risk. Only one genetic model of rs1060555 polymorphism showed a significant protective association with cancer (COD2: OR = 0.80, p = .048). The outcomes of TSA also validated the findings of the meta-analysis. Conclusion: This study summarizes that rs11064, rs1045241, and rs1045242 polymorphisms of TNFAIP8 gene and rs8126 polymorphism of TNFAIP2 gene are significantly linked with the risk of cancer development. This meta-analysis was registered at INPLASY (registration number: INPLASY202270073).
Clinical Significance of Preoperative Naples Prognostic Score in Patients With Non-Small Cell Lung Cancer
Authors: Ren Dahu , Wu Wenbo , Zhao Qingtao , Zhang Xiaopeng , Duan Guochen
Published: October 2022

Background: Naples Prognostic Score (NPS) is a novel score based on inflammatory-nutritional indicators. We aimed to analyze the prognostic value of the Naples Prognostic Score in non-small cell lung cancer (NSCLC) patients following surgery. Methods: A total of 319 NSCLCpatients following surgery were analyzed in the retrospective cohort study. We analyzed the predictive value of Naples Prognostic Score for overall survival and recurrence-free survival in postoperative non-small cell lung cancer patients by using Kaplan-Meier survival curves and multivariate Cox regression analysis. At the same time, the time-dependent ROC and the area under curves were also created to compare the accuracy of different scoring systems. Results: According to NPS, we divided all patients into 3 groups，120 patients were divided into group 0, 161 patients were divided into group 1, and 38 patients were divided into group 2. The median survival time for all patients is 32 months, and the median survival times for different groups were 35 months, 31 months, and 28 months, respectively. The overall survival and recurrence-free survival survival curves of different groups were significantly different (both P < .05), and patients in the higher NPS groups had a disappointing prognosis. NPS may be an independent prognostic factor for overall survival and recurrence-free survival, according to the results of multivariate analysis (both P < .05). The area under curve showed that the accuracy of the NPS was significantly better than other score systems. Conclusions: The NPS is closely related to the long-term survival prognosis of patients with NSCLC, especially in stage III patients.
Cytoplasmic G Protein-Coupled Estrogen Receptor 1 as a Prognostic Indicator of Breast Cancer: A Meta-Analysis
Authors: Zhang Duo , Wang Jinpeng , Chen Hong , Yan Shunchao
Published: October 2022

Purpose: To determine whether G protein-coupled estrogen receptor 1 (GPER1) is a suitable biomarker to predict the treatment outcome of breast cancer (BC). Methods: A meta-analysis of the literature was performed to clarify the correlation between GPER1 protein expression and BC outcome. The relationship between GPER1 mRNA expression and survival was analyzed using Breast Cancer Gene-Expression Miner (bc-GenExMiner) v4.6 software. Results: Six studies involving 2697 patients were included in the meta-analysis. Four studies reported the correlation between GPER1 protein expression and relapse-free survival (RFS) and 4 others reported the impact of GPER1 protein expression on overall survival (OS). The results showed that high GPER1 protein expression was not associated with RFS (hazard ratio [HR] = 1.58; 95% confidence interval [CI] = 0.71-3.48; P = .26) or OS (HR = 1.18; 95% CI = 0.64-2.18; P = .60). Subgroup analysis suggested that nuclear expression of GPER1 was not associated with OS (HR = 0.91; 95% CI = 0.77-1.08; P = .30), but high expression of cytoplasmic GPER1 was significantly associated with longer OS (HR = 0.69; 95% CI = 0.55-0.86; P = .001). Furthermore, the association of GPER1 mRNA and OS of BC patients was analyzed using bc-GenExMiner v4.6. Two data sets involving 4016 patients were included in the analysis. The targeted prognostic analysis results showed that high mRNA expression of GPER1 was predictive of better OS in BC patients (HR = 0.71; 95% CI = 0.59-0.86; P = .0005), which was remarkably similar to the result of cytoplasmic GPER1. Further subgroup analysis demonstrated that high mRNA expression of GPER1 was predictive of better OS in estrogen receptor (ER)-positive, but not ER-negative or triple-negative BC patients. Conclusions: High mRNA and cytoplasmic protein expression of GPER1 were predictive of better OS of BC patients.
Synergistic Effects of Zanubrutinib Combined With CD19 CAR-T Cells in Raji Cells in Vitro and in Vivo
Authors: Ye Xiupeng , Liu Meijing , Lv Cuicui , Li Yeqiong , Chen Lan , Zhang Jin , Mu Juan , Deng Qi
Published: October 2022

Background and Objects: Bruton's tyrosine kinase inhibitors are commonly used and effective for lymphoma and chronic lymphocytic leukemia (CLL). Ibrutinib might improve the effect of anti-cluster of differentiation 19 (CD19) chimeric antigen receptor (CD19 CAR) T-cell therapy in lymphoma, but the effects of zanubrutinib combined with CAR-T cells is unclear. Methods: We selected a low effect-target ratio (E:T = 1:3) to study this synergistic effect in vitro. The programed cell death protein 1 (PD-1) expression in CD19 CAR-T cells and immune phenotype of T lymphocytes were analyzed by flow cytometry (FCM). We selected CD19 CAR-T cells of a patient with diffuse large B cell lymphoma (DLBCL) to study the synergistic effect of zanubrutinib with CAR-T cells by bioluminescence imaging monitoring. The CD19 CAR-T cells expansion in mice was compared by FCM. Results: Zanubrutinib and ibrutinib had dose-dependent toxicity on both CAR-T cells and lymphoma cells. But there was no significant synergistic effect of the CD19 CAR-T cells combined with zanubrutinib/ibrutinib in vitro. The PD-1 expression in CD19 CAR-T cells increased when the CD19 CAR-T cells were co-cultured with Raji cells and decreased when ibrutinib was added in culture, but zanubrutinib had no such effect. The extinction of luciferase expression was more obvious in the polytherapy group of ibrutinib and CD19 CAR-T cell than that in the other groups. Moreover, the proportion of CAR-T cells in the combination therapy group of CD19 CAR-T cells and ibrutinib was higher than that of the polytherapy group of CD19 CAR-T cells with zanubrutinib group. The synergistic effect could be observed obviously in mice receiving ibrutinib combined with CD19 CAR-T cells. But zanubrutinib cannot perform joint therapy effect either in vitro or in mice. Conclusion: Zanubrutinib might have no joint therapy effect with CD19 CAR-T cells neither in vitro nor in mice, but the mechanism of different curative effects requires our further research and exploration.
Epidemiological, Clinical, and Oncological Outcomes of non-Alcohol Drinking and non-Smoking Laryngeal Squamous Cell Carcinoma Patients: A Distinct Entity
Authors: Huang Qiang , Guo Yang , Shen Yujie , Hsueh Chi-Yao , Tao Lei , Zhang Ming , Wu Chunping , Gong Hongli , Zhou Liang
Published: October 2022

Purpose: To explore the discrepancy in clinicopathological and prognostic features between smoking and alcohol drinking (SA) and non-smoking and non-alcohol drinking (NSNA) patients with laryngeal squamous cell carcinoma (LSCC). Methods: This retrospective study including 1735 patients with LSCC was conducted from January 2005 to December 2010, which were categorized into 4 groups, NSNA group, smoking only group, alcohol-drinking only group, and SA group. We compared overall survival (OS) and disease-free survival (DFS) using the Kaplan–Meier method and indicated clinicopathological features by Cox proportional hazards regression models before and after propensity score matching (PSM). Results: A total of 415 patients (23.92%) were identified as NSNA. The SA group was predominantly patients ≤60 years old (46.63%) while the NSNA group was more older (58.07%). NSNA group was more likely to present at earlier disease stage and more female. No significant difference in OS ( P = .685) and DFS ( P = .976) was found between the 2 groups. In addition to age and recurrence and metastasis being common independent prognostic factors in terms of OS in both groups of patients, NSNA group also exhibited other factors, namely tumor area >3.7 cm2 and positive resection margin. For DFS, N + stage, tumor size >3.7 cm2, and positive resection margin were prognostic features specific to NSNA group. Conclusion: The outcome is similar in LSCC patients with and without SA. NSNA group shows a distinct profile from that found in SA group. Clinicopathological features from NSNA group should be considered for LSCC management.
New Electrographic Marker? Evaluation of Sleep Spindles in Children with Attention Deficit Hyperactivity Disorder
Authors: Özbudak Pınar , Özaslan Ahmet , Temel Esra Ülgen , Güney Esra , Serdaroğlu Ayşe , Arhan Ebru
Published: October 2022

Introduction: Attention deficit and hyperactivity disorder (ADHD) is one of the most common developmental disorders in childhood which lasts lifelong. Sleep structure and sleep spindle features are disorganized in ADHD. In this study, we aimed to look for a new, simple, inexpensive, and an easily detectable electrographic marker in the diagnosis of ADHD by using electroencephalography (EEG). Method: We included treatment free 35 patients with ADHD and 32 healthy children (HC) who were examined by polysomnography (PSG) and EEG for sleep disorders. The ADHD group were separated into three groups according to predominant presentations of ADHD. We determined the sleep staging and slow and fast sleep spindles, calculated each spindle's amplitude, frequency, activity, duration and density at non rapid eye movement (REM) sleep stage 2. Results: Slow sleep spindle's amplitude, duration, density and activity are significantly higher in ADHD group (most significant in ADHD-I) than the HC group (p < 0,05). Sleep spindle's features are not statistically significant between in ADHD subgroups. Conclusions: In children with ADHD, slow sleep spindles showed higher amplitude, activity, density and duration in the frontal regions. These results indicate that slow sleep spindles in children with ADHD may reflect executive dysfunction and slow frontal spindles may be useful as a new electrographic marker in children with ADHD. This is the first study of its kind evaluating all aspects of sleep spindles in ADHD patients.
Uplink non-orthogonal multiple access in heterogeneous networks: A review of recent advances and open research challenges
Authors: Rehman Bilal Ur , Babar Mohammad Inayatullah , Ahmad Arbab Waheed , Amir Mohammad , Habib Wasim , Farooq Muhammad , Abdel Azim Gamil
Published: October 2022

Fifth-generation wireless communications provide several benefits, including high throughput, lower latency, massive connectivity, considerable improvement in the number of users, higher base station capacity, and achieved quality of service. Non-orthogonal multiple access, an effective approach for sharing the same radio resources, has been highlighted as a viable technology in the fifth-generation wireless networks to achieve the demands of available bandwidth, user connectivity, and application latency. Non-orthogonal multiple access and heterogeneous networks have recently emerged as promising network infrastructures for enhancing the spectrum capacity and accommodating more users by sharing the same resources with high throughput. This potential capability has made the non-orthogonal multiple access–enabled heterogeneous networks a new research topic in the modern era. In this survey, the concept of non-orthogonal multiple access and its significance in different emerging technologies has been well explored. Furthermore, this survey covers a systematic overview of the state-of the-art techniques based on non-orthogonal multiple access–enabled heterogeneous networks and devising taxonomy for uplink non-orthogonal multiple access–enabled heterogeneous networks. In addition, this survey provides critical insights and identifies several open research challenges considering the uplink non-orthogonal multiple access–enabled heterogeneous networks.
Left Atrial Appendage Morphology and Course of the Circumflex Artery: Anatomical Implications for Left Atrial Appendage Occlusion Procedures
Authors: Batko Jakub , Rams Daniel , Filip Grzegorz , Bartoszcze Artur , Kapelak Bogusław , Bartuś Krzysztof , Litwinowicz Radosław
Published: October 2022

Objective:

The aim of this study was to evaluate the anatomic topography of the circumflex artery (Cx) and left atrial appendage (LAA) and to determine the safety zones for epicardial LAA closure and LAA occlusion procedures.

Methods:

The left coronary artery was segmented and visualized from 116 computed tomography angiography scans. Four points were located on the Cx portion periappendicularly, starting from the entry point. The landing zone plane was defined as parallel to the LAA orifice at the level of the beginning of the periappendicular course of the Cx, and the plane of the neck bend was located at the end of the LAA neck. A distance smaller than 2 mm was considered a dangerous distance.

Results:

The distance between the Cx and the LAA landing zone was 4.3 ± 2 mm. The distance between the Cx and the LAA neck bend was 5.1 ± 2.2 mm. The distance between the Cx and the LAA bottom surface was 5.8 ± 2.9 mm. In 38.8% of patients, at least 1 distance between Cx and LAA was smaller than 2 mm in at least 1 dimension. These distances occurred in 30.2% of the LAA landing zone dimensions, 19.8% of LAA neck bend dimensions, and 11.2% of the LAA bottom surface distances.

Conclusions:

The study showed that most dangerous distances (30.2%) occurred in the LAA landing zone dimension. The data showed that landing zones more distal from the orifice of the LAA are safer in terms of Cx damage. Therefore, LAA closure should always be performed with caution, to avoid iatrogenic complications.
Endovascular treatment of distal medium vessel occlusions using microcatheter aspiration thrombectomy
Authors: Grieb Dominik , Greling Björn , Schulz Katharina , Boxberg Frederik , Melber Katharina , Abu-Fares Omar , Lanfermann Heinrich , Schlunz-Hendann Martin , Meila Dan
Published: October 2022

Background and purpose

Recent studies suggest that endovascular treatment (EVT) in distal medium vessel occlusion (DMVO) stroke is beneficial even beyond middle cerebral artery (MCA) - M2 segment. However, data about aspiration thrombectomy of DMVOs is scarce since common state-of-the-art aspiration catheters are usually too large for small distal intracranial arteries. We report our initial experiences using the microcatheter aspiration thrombectomy (MAT) technique as frontline therapy for acute DMVOs in the MCA territory.

Methods

We retrospectively analyzed all acute ischemic stroke (AIS) patients that underwent MAT of a primary or secondary DMVO in the M3 or M4 segment between January 2019 and October 2021. Recanalization rates, procedural safety and outcome data were recorded.

Results

MAT of acute M3 and M4 occlusions was performed in 19 patients with AIS. Six had isolated DMVO strokes, 13 had secondary DMVOs during EVT of a proximal large vessel occlusion. Successful revascularization to DMVO TICI ≥ 2b was achieved in 58% (11/19) with a single pass in all of them. The median National Institutes of Health Strokes Scale (NIHSS) score at admission and discharge was 12 and 3, respectively. 68% (13/19) of the patients had a good clinical outcome at discharge (modified Rankin Scale 0-2). No symptomatic complications related to MAT occurred.

Conclusions

MAT of DMVOs in the MCA territory is technically feasible and effective. Compared to stent retriever-based thrombectomy in DMVOs the hemorrhagic complication rate appears notably lower. Further studies are needed to validate the benefit of mechanical thrombectomy in the distal intracranial vasculature.
Counter-hegemonic collaborations or alliances of the underdogs? The case of TeleSUR with Al-Mayadeen, RT and CGTN
Authors: Morales Pablo Sebastian
Published: October 2022

This study explores how news channels from the Global South challenge western narratives by co-producing TV programmes. It focuses on Telesur (Venezuela) and its collaborations with RT (Russia), Al-Mayadeen (Lebanon) and CCTV/CGTN (China). By combining quantitative and qualitative methods, this paper examines the structure of these collaborations, the discursive construction of alternative narratives and their contribution to countering hegemonic discourses. The findings show that the efforts to construct counterhegemonic narratives are most evident in the co-productions with RT and Al-Mayadeen. Although the co-production with CGTN focusses on culture, it is nonetheless possible to identify the broadcasters’ distinct ideological agendas.
Multivariate analysis for assessing the thermal performance of vertical opaque envelopes in extended regions
Authors: Thomas L. P. , Marino B. M. , Muñoz N.
Published: October 2022

We introduce a statistical methodology to evaluate the thermal performance of vertical opaque envelopes and provide the most adequate design of energy-efficient buildings located across extended regions. The analytical procedure was applied to the extensive Argentinian territory with a variety of climates and a limited number of networked meteorological stations. Although the study was conducted over a full year, results are presented for January and June, when the building energy demand for heating and cooling is most significant, taking into account the local climate, the thermal properties of the walls and the effects of the daily variation in the solar radiation. By using the Fourier series expansion of the sol-air temperature and multivariate analysis, we first correlated the weather data and the steady-state and time-dependent heat fluxes transmitted by conduction through five types of typical walls facing north and south in 10 climatically differentiated cities where full weather data were recorded. Then, the mean values of the sol-air temperature and the amplitude of its time variations were interpolated throughout the territory, thus yielding the spatial distributions of these parameters for a typical day in the months of interest. Finally, the calculation of the heat fluxes exchanged through building opaque envelopes was extended to the whole country.
The Dissident: ‘Sawing’ political activism by media corporation?
Authors: Dakroury Aliaa
Published: October 2022

Premiered in 2020, and although representing a grim story to narrate the Khashoggi story – a Saudi prominent journalist – who was ambushed, killed, and his body dismembered in his own country's consulate, The Dissident is more than simply a documentary. It is arguably a narration of the need for freedom of expression and political reform in the Arab world generally and Saudi Arabia in particular. This paper highlights the struggle to disseminate The Dissident documentary publicly as none of the major media corporation streamers (HBO, Netflix, Amazon, and Apple) offered to carry it. The way giant media corporations treat the information in this case not only as a commodity but as a means to avoid political tensions affecting their revenues in the markets. The article addresses this case study from a freedom of expression and the right to communicate perspective arguing for the need of an actual media reform within the middle east media system so journalists, like Khashoggi.