bluuebunny/crossref_metadata_2025 huggingface dataset:
ПІДГОТОВКА ФАХІВЦІВ ДО ЗДІЙСНЕННЯ НЕПЕРЕРВНОЇ ЕКОНОМІЧНОЇ ОСВІТИ ДІТЕЙ, ЮНАЦТВА ТА ГОСПОДАРСЬКО-ЕКОНОМІЧНОГО ПРОСВІТНИЦТВА ДОРОСЛИХ У ЗАХІДНІЙ УКРАЇНІ (КІНЕЦЬ ХІХ – ПОЧАТОК 40-х рр. ХХ ст.)
Authors: Білавич Галина , Багрій Марія , Гречаник Наталія
Published: March 2023

Стаття присвячена проблемі неперервної економічної освіти дітей, юнацтва, дорослих у Західній Україні, увиразнено історичний досвід практики підготовки фахівців до здійснення господарсько-економічного виховання учнів та дорослих наприкінці ХІХ – на початку 40-х рр. ХХ ст. Попри регіональну специфіку, зміст підготовки вчителів до керівництва процесом виховання господарсько-економічної культури особистості мав багато спільного в Галичині, Буковині й Закарпатті, особливо за часів панування Австро-Угорщини. За міжвоєнного періоду ХХ ст. у Польщі сформувалася складна система канікулярно-курсової підготовки та підвищення кваліфікації педагогічних кадрів. За доби Другої світової війни не вдалося налагодити системної підготовки фахівців до виховання господарсько-економічної культури учнів, за винятком території Генерального губернаторства.
СТРУКТУРА, КОМПОНЕНТИ, КРИТЕРІЇ СФОРМОВАНОСТІ ПРОФЕСІЙНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ ОПЕРАТОРІВ З ОБРОБКИ ІНФОРМАЦІЇ ТА ПРОГРАМНОГО ЗАБЕЗПЕЧЕННЯ
Authors: Газдик Мирослава
Published: March 2023

У статті проаналізовано проблему професійної підготовки майбутніх операторів з обробки інформації та програмного забезпечення у закладах професійної (професійно-технічної) освіти. Зʼясовано, що формування професійної компетентності майбутніх операторів з обробки інформації та програмного забезпечення у процесі фахової підготовки залежить від упровадження цілей й змісту професійної (професійно-технічної) освіти, умов навчання та виховання майбутніх фахівців, соціальних потреб суспільства. Обґрунтовано, що впровадження виявлених компонентів (мотиваційно-цільовий; когнітивно-пізнавальний; особистісно-результативний; практично-діяльнісний) та визначених відповідних критеріїв уможливить досягнення сформованості професійної компетентності майбутніх операторів з обробки інформації та програмного забезпечення у процесі фахової підготовки.
ІНДИВІДУАЛЬНА ПРОГРАМА РОЗВИТКУ УЧНЯ З ОСОБЛИВИМИ ОСВІТНІМИ ПОТРЕБАМИ
Authors: Пантюк Микола , Садова Ірина , Ілляш Соломія
Published: March 2023

У статті досліджено, що індивідуальна програма розвитку – це документ, який визначає індивідуальні напрями та вимоги до навчання, характер освітніх послуг, форми підтримки, а також гарантує забезпечення права на якісну освіту дітей з особливими освітніми потребами. Зʼясовано, що основне завдання індивідуальної програми розвитку – забезпечити індивідуальний підхід до потреб таких осіб, заснований на потенціалі їх фізичного, психологічного та соціального розвитку, а також планування й обовʼязкову реалізацію необхідних освітніх стратегій для цієї категорії учнів. Обґрунтовано алгоритм упровадження індивідуальної програми розвитку в умовах закладу загальної середньої освіти, який складається з підготовчого, основного та підсумкового етапів.
ДОСЛІДЖЕННЯ ЕМОЦІЙНО-МОТИВАЦІЙНОГО КОМПОНЕНТА ПІДГОТОВКИ МАЙБУТНІХ ВИХОВАТЕЛІВ ДІТЕЙ РАННЬОГО ВІКУ (КОНСТАТУВАЛЬНИЙ ЕТАП)
Authors: Попович Оксана
Published: March 2023

У статті представлено дослідження емоційно-мотиваційного компонента підготовки майбутніх вихователів дітей раннього віку. Здійснено систематизацію та системний опис поняття “професійний габітус”, що уможливлює обґрунтування центрального аспекта формування досвіду здобувачів вищої освіти, їх розвиток відповідно до вимог спеціальності, яку здобувають. У межах дослідження звернено увагу на той факт, що підготовка майбутніх вихователів повинна бути спрямована на формування, розвиток і збагачення культурного потенціалу (інтелектуального, психологічного й соціального капіталу). Доведена важливість емоційно-мотиваційного компонента готовності майбутнього вихователя до роботи з дітьми раннього віку.
ПРОФЕСІЙНИЙ САМОРОЗВИТОК МАЙБУТНЬОГО ВЧИТЕЛЯ ОБРАЗОТВОРЧОГО МИСТЕЦТВА
Authors: Стрілець Ольга
Published: March 2023

У статті розглянуто проблеми саморозвитку майбутнього вчителя образотворчого мистецтва. Проаналізовано науково-методичну літературу з питань професійного саморозвитку майбутнього вчителя образотворчого мистецтва. За результатами аналізу науково-методичної літератури визначено й охарактеризовано методологічні підходи в контексті аксіологічного, субʼєктно-особистісного, креативно-рефлексивного, творчо-діяльнісного підходів.
ТЕОРЕТИЧНІ АСПЕКТИ ФОРМУВАННЯ ПРОФЕСІЙНОЇ ГОТОВНОСТІ МАЙБУТНІХ ТРЕНЕРІВ З ЛЕГКОЇ АТЛЕТИКИ ДО РОБОТИ ІЗ ДІТЬМИ З ПОРУШЕННЯМ ОПОРНО-РУХОВОГО АПАРАТУ
Authors: Осадченко Тетяна
Published: March 2023

У статті пропонується теоретичний аналіз проблеми формування професійної готовності майбутніх тренерів з легкої атлетики. Здійснено характеристику осіб з порушенням опорно-рухового апарату. Визначено, що професійна готовність майбутнього тренера легкої атлетики до роботи із дітьми з порушенням опорно-рухового апарату є педагогічним процесом, що становить компонент цілісної професійної підготовки майбутнього тренера, спрямований на усвідомлення важливості та необхідності формування знань, умінь і навичок у сфері адаптивного спорту, що забезпечують фізкультурно-спортивну діяльність із дітьми з порушенням опорно-рухового апарату під час легкоатлетичних занять.
ІНСТРУМЕНТАРІЙ ОЦІНЮВАННЯ СФОРМОВАНОСТІ ТЕХНІКО-ТЕХНОЛОГІЧНОЇ КОМПЕТЕНТНОСТІ БАКАЛАВРІВ ПРОФЕСІЙНОЇ ОСВІТИ ЗА СПЕЦІАЛІЗАЦІЄЮ “ТРАНСПОРТ”
Authors: Храпач Дмитро
Published: March 2023

Стаття присвячена висвітленню результатів розроблення інструментарію оцінювання сформованості техніко-технологічної компетентності бакалаврів професійної освіти за спеціалізацію “Транспорт”. Схарактеризовані структура та складові інструментарію оцінювання сформованості техніко-технологічної компетентності, до яких віднесені критерії, показники, рівні та методики діагностики. Обґрунтовані рівні сформованості техніко-технологічної компетентності бакалаврів професійної освіти за спеціалізацію “Транспорт”: креативний (високий), базовий (середній), репродуктивний (низький).
An Exact Solution of Nonlinear Schrödinger Equation in a Lossy Fiber System Using Direct Solution Method
Authors: Zulfi Abdullah  , Trengginas Eka Putra Sutantyo  , Mahdhivan Syafwan  , Ahmad Ripai  , Hanifah Azzaura Musyayyadah  , Mohamad Nazri Abdul Halif
Published: March 2023

We present an exact solution of the nonlinear Schrödinger equation (NLSE) for beam propagation in nonlinear fiber optics. It is a lossy fiber system with the beam as solitons. Fiber losses are understood to reduce the peak power of solitons along the fiber length. That is due to its value depending on the fiber attenuation constant of α. Considering fiber loss features on the equation, we write one set modification of the NLSE and make models the main topic of our work. We solved the model and found a straightforward analytical solution of modified NLSE for the system via the direct solution method. To the best of our knowledge, no literature has presented such as solution yet. By substituting them into equations, we validate solutions. It is valid as an exact solution to the NLSE. Lastly, we found a solution offering soliton propagation suitable for the system under study.
Media Sosial Sebagai Teknologi Informasi Penggerak Percepatan Pemanfaatan Potensi Desa Mekarjaya Ciawigebang Kuningan
Authors: Fauziah  , Aah Sumiah  , Dede Irawan  , Harun Assidik  , Abdul Aziz Alfarizy
Published: March 2023

Information technology can be a link between one person and many people which allows information to be conveyed quickly. Social media is one way that information can be conveyed to the public by providing benefits that can attract many groups, parents, children, teenagers, entrepreneurs, educators, workers, etc. With social media, the information that you want to spread to advance a business from a potential community in rural areas, especially in Mekarjaya Village, is still felt to be underused because one of the factors is that most of the users of social media are young people, while in Mekarjaya Village, most of the farmers are people who already old age. The total population of the country of Indonesia is 256.4 million people, as many as 130 million people or around 49 percent of them are active users of social media. Social media-based information technology seminars for the people of Mekarjaya village to be able to develop village potential products and provide economic benefits for the community and expand their reach to areas in need. This seminar is summarized in the Community Service Activities (PkM) program organized by Kuningan University by involving lecturers and students as a form of community service to improve society's quality.
Language metaphor generating tropes
Authors: Derevskova Elena , Dorfman Oksana , Pozdniakova Natalia
Published: March 2023

The article deals with the trope system of the Russian language. The aim of the article is to reveal the stages of analysis which students need to pass to identify different tropes based on usual metaphor. For mastering theoretical material the authors suggest the teaching technique founded on the step-by-step topic learning. The chosen form of the material presentation has determined the direction of tasks combined into three modules: "Language metaphor - Artistic metaphor"; "Language Metaphor - Personification," "Language Metaphor - Figurative comparison". Module work is connected, firstly, with the tasks involving consulting with dictionaries, studying the structure of dictionary entries, revealing the lexical-semantic variants of a polysemant word that determine the specifics of an individual trope. Secondly, the authors suggest types of exercises which involve context observing and help students rethink the meaning of a word and then correctly identify the functioning of the trope in the text. While studying the topic, each of the modules gives the opportunity to combine knowledge of theory and practical analysis of objective material and that makes the results of research work valuable, and conclusions conscious. While training bachelor-philologists, linguists, teachers of the Russian language and literature and students of general and (or) secondary general education, the suggested technique for studying complex issues of lexical semantics and trope system allows students to develop skills that implement professional competence related to the readiness to use systematized theoretical and practical knowledge to set and solve research problems in the field of education.
Reflection of Chinese Traditional Cultural Values in Modern Clothing
Authors: Yang jing
Published: March 2023

In the context of modern processes of global integration and the comprehensive strengthening of China, the desire of world culture for integration also contributes to the development of global heterogeneity, localization and the rise of national culture. The Chinese civilization is currently the only ancient civilization that has not been interrupted in its development. Throughout the history of more than five thousand years in the course of its development, Chinese civilization has been able to form a unique cultural tradition that has become a spiritual source for the Chinese people. Since China's culture is an important part of the history of world civilization, its traditional culture can be represented in various forms through various cultural media, such as modern clothing. This article examines the reflection of Chinese traditional culture manifested in modern clothing both in China and abroad, analyzes, studies, compares and summarizes the differences in the language and methods of expression of Chinese traditional culture between the West and China. In addition, this article summarizes the methodological significance of heritage and innovation in the field of the manifestation of Chinese traditional culture in modern clothing, due to which modern Chinese clothing in the international fashion system is gradually moving from the concept of "alien" to the concept of "unique".
Perioral Contact Dermatitis Caused by Limonene Hydroperoxide in Cannabis Vaping Products
Authors: Mai Kevin , Pham Quang D. , Haquang Joseph , Pham Diem Q.
Published: March 2023

Limonene is a fragrant terpene commonly found in household and cosmetic products due to its fresh aroma. When exposed to air, limonene autoxidizes to form limonene hydroperoxide, a potent allergen that can cause allergic contact dermatitis. Recently, as the popularity and availability of limonene increased, it has been incorporated into novel products such as flavoring agents for electronic cigarettes or vapes. With the rising acceptance and popularity of marijuana, this usage has extended to cannabis vaping products. Here, we report an unusual presentation of an allergic contact dermatitis reaction to limonene hydroperoxide stemming from cannabis vaping products.
Sunscreen Knowledge and Sun Protective Behaviors among Medical Students at a Southern US Institution
Authors: Olivet Meagan , Kole Lauren
Published: March 2023

Literature has demonstrated that medical students have discrepancies in their knowledge and their execution of best practices concerning sun protection. Additionally, despite knowing the harms of tanning, medical students acknowledge that they desire tan skin. A survey was sent to medical students at a Southeastern institution to determine their knowledge of sun safety and their personal practices. The survey was distributed through institutional emails and student messaging applications. Current medical students at the home institution were eligible to complete the survey. The survey was designed with guidelines from the American Academy of Dermatology in mind. Chi-square analysis was performed by SPSS Version 28.0.1.1 (14). The majority of medical students are knowledgeable of best sun protective practices, though many students do not carry out these practices. For example, 88% of students know to reapply sunscreen every 2 hours; however, only 28% always reapply at the correct interval. Several demographic differences were present between self-reported race and gender groups in the knowledge, behaviors, and tanning questions. Medical students are knowledgeable of best practices for preventing sun damage; however, their personal behaviors can deviate and societal pressure for some students to have “tanned” skin is challenging to overcome.
Deucravacitinib in moderate to severe plaque psoriasis: liver transaminase results from the phase 3 POETYK PSO program
Authors: Lebwohl Mark , Egeberg Alexander , Linaberry Misti , Hoyt Kim , Banerjee Subhashis , Kisa Renata M. , Strober Bruce
Published: March 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor, is approved by the US Food and Drug Administration for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. In the phase 3 POETYK PSO-1 and PSO-2 trials, deucravacitinib treatment did not result in clinically meaningful changes across multiple laboratory parameters, including liver transaminases and bilirubin. The current analysis assessed changes in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the pooled POETYK PSO-1 and PSO-2 population over 16 weeks.

Methods: In POETYK PSO-1 and PSO-2, patients with moderate to severe plaque psoriasis were randomized 1:2:1 to oral placebo, deucravacitinib 6 mg once daily, or apremilast 30 mg twice daily. Patients randomized to placebo crossed over to deucravacitinib at Week 16 in both trials. This analysis uses data from POETYK PSO-1 and PSO-2 pooled by treatment group from Weeks 0-16. ALT and AST were evaluated as mean levels over time, shifts from baseline in Common Terminology Criteria for Adverse Events (CTCAE version 5.0) severity grade, and fold-increase from upper limit of normal (ULN). Patient-level data were evaluated for those who experienced an elevation ≥3´ ULN for ALT or AST in the first 16 weeks of treatment.

Results: The pooled POETYK PSO-1 and PSO-2 population included placebo (n=419), deucravacitinib (n=842), and apremilast (n=422). ALT and AST results were available for 413, 833, and 419 patients, respectively. Mean levels of ALT and AST did not change over 16 weeks in any treatment arm. Shifts upwards ≥2 CTCAE grades from baseline in ALT and AST over Weeks 0-16 occurred at a low frequency overall; rates were comparable in patients treated with deucravacitinib (ALT, 0.4%; AST, 0.5%), apremilast (ALT, 0.5%; AST, 0.5%), and placebo (both ALT and AST, 0%). In addition, ALT and AST elevations ≥3´ ULN were infrequent (ALT: placebo 1.2%, deucravacitinib 1.1%, apremilast 0.5%; AST: placebo 0.5%, deucravacitinib 1.6%, apremilast 0.7%). Almost all ALT or AST elevations ≥3´ the ULN between baseline and Week 16 were transient and/or could be traced to underlying liver conditions or concomitant medications.

Conclusion: Treatment with deucravacitinib, apremilast, or placebo led to increases in ALT or AST levels from baseline over 16 weeks in a few patients; the increases that did occur were potentially related to underlying liver dysfunction, alcohol use, or use of concomitant medications.
Deucravacitinib long-term efficacy with continuous treatment in plaque psoriasis: 2-year results from the phase 3 POETYK PSO program
Authors: Lebwohl Mark , Warren Richard B. , Sofen Howard , Imafuku Shinichi , Paul Carle , Szepietowski Jacek C. , Spelman Lynda , Passeron Thierry , Colston Elizabeth , Hippeli Lauren , Napoli Andrew , Kisa Renata M. , Banerjee Subhashis , Menter Alan , Thaçi Diamant , Blauvelt Andrew
Published: March 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved by the US Food and Drug Administration for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. In the pivotal phase 3 POETYK PSO-1 trial, deucravacitinib was superior to placebo and apremilast using multiple clinical endpoints, including PASI 75 and sPGA score of 0 or 1 (clear/almost clear skin) at Week 16. Clinical efficacy was maintained through Week 52 on continued treatment. We examined long-term clinical efficacy in patients randomized to deucravacitinib on Day 1 in PSO-1 who opted to continue treatment at Week 52 in the long-term extension (LTE) trial.

Methods: In the 52-week POETYK PSO-1 trial, adult patients were randomized 2:1:1 to deucravacitinib 6 mg once daily, placebo, or apremilast 30 mg twice daily; upon trial completion, patients could enter the LTE and receive deucravacitinib. Efficacy endpoints included PASI 75, PASI 90, and sPGA 0/1. Maintenance of response was assessed in Week 16 PASI 75 responders continuing treatment in the LTE. Modified nonresponder imputation (mNRI) was used to impute missing data; patients discontinuing due to psoriasis worsening were imputed as nonresponders. Efficacy results used as-observed data and treatment failure rule imputation.

Results: Of 332 patients randomized to deucravacitinib in PSO-1, 265 completed the trial and entered the LTE, including 173 Week 16 PASI 75 responders. The mNRI population included 262 deucravacitinib patients entering the LTE, including 171 Week 16 PASI 75 responders; patients failing to reach the Week 112 assessment or discontinuing as of October 1, 2021, were excluded. At Week 112 (LTE Week 60), mNRI response rates among deucravacitinib patients entering the LTE were 82.4% (PASI 75), 55.2% (PASI 90), and 66.5% (sPGA 0/1). Efficacy was maintained up to 112 weeks in Week 16 PASI 75 responders continuing treatment, including PASI 75 response rates at Weeks 16, 52, and 112 (100%, 90.1%, 91.0%, respectively), PASI 90 (62.6%, 64.9%, 63.0%), and sPGA 0/1 (84.2%, 73.7%, 73.5%).

Conclusion: Clinical efficacy was maintained up to 112 weeks with continuous treatment, further supporting deucravacitinib as an effective treatment for patients with moderate to severe plaque psoriasis.
Investigator global assessment (IGA) of Acne Vulgaris and IGA Success among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S in PROSES study: Analysis by concomitant medication
Authors: Baldwin Hilary , Del Rosso James , Kircik Leon , Stein Gold Linda , Hebert Adelaide , Rieder Evan , Alexis Andrew , Harper Julie , Fried Richard , Narayanan Siva , Koscielny Volker , Kasujee Ismail , Graber Emmy
Published: March 2023

Introduction: The objective of this analysis was to evaluate facial IGA and the associated IGA success, stratified by the use of concomitant acne medications, among AV patients administered sarecycline in community practices across the U.S.

Methods: A single-arm, prospective cohort study (PROSES) was conducted with moderate-to-severe non-nodular AV patients >9 years who were prescribed sarecycline in real-world community practices in the US. Facial IGA of AV status was collected on a five-point adjectival response scale (0(clear)-4(severe)). IGA success at week-12 was defined as >2-grade improvement and score 0-clear or 1-almost clear at week-12. Proportion of patients achieving IGA success was analyzed, stratified by the use of any concomitant AV medication during the study (Yes vs. No (monotherapy)).

Results: A total of 253 AV patients completed the study (adults 60.08% (mean age 26.63); pediatric 39.92% (mean age 14.81); female: 66.40%; white/caucasian: 68.38%, african-american: 8.70%; other races: 22.92%). Per IGA at baseline, 86.56% & 13.44% had moderate and severe AV, respectively. Key concomitant treatments for AV observed during the study included: topical retinoids (24.51%), topical antibiotics (13.44%), benzoyl peroxide (5.93%), topical dapsone (5.14%) and other (17.00%; predominantly adapalene/benzoyl peroxide). Half of the patients (49.80%) were on sarecycline monotherapy (i.e., did not use any concomitant treatments for AV). For the overall study cohort, IGA success at week-12 was 58.89%. At week-12, IGA success was 59.84% among patients using concomitant AV medications, and 57.94% among patients using no concomitant AV medications (i.e., on sarecycline monotherapy).

Conclusion: Within the study cohort administered sarecycline, a narrow-spectrum, tetracycline-derived antibiotic, for 12 weeks, majority of patients achieved IGA success at week-12, and the outcomes were similar among patients on sarecycline monotherapy and those on concomitant AV medications.
Adjuvant therapy with nivolumab versus placebo in patients with resected stage IIB/C melanoma (CheckMate 76K)
Authors: Long Georgina V. , Del Vecchio Michele , Weber Jeffrey , Hoeller Christoph , Grob Jean-Jacques , Mohr Peter , Grabbe Stephan , Dutriaux Caroline , Chiarion-Sileni Vanna , Mackiewicz Jacek , Rutkowski Piotr , Arenberger Petr , Quéreux Gaëlle , Meniawy Tarek , Ascierto Paolo A. , Durani Piyush , Lobo Maurice , Campigotto Federico , Gastman Brian , Kirkwood John M.
Published: March 2023

Patients with resected stage IIB/C melanoma are at high risk of recurrence with outcomes similar to patients with resected stage IIIB disease. Adjuvant NIVO has shown benefit in patients with resected stage III-IV melanoma. The phase 3 CheckMate 76K (NCT04099251) trial compared adjuvant NIVO vs PBO in patients with completely resected stage IIB/C melanoma. Patients aged ≥12 years were stratified by T category and randomized 2:1 to receive NIVO 480 mg or PBO, intravenously Q4W for 12 months. The primary endpoint was recurrence-free survival (RFS); safety was a key secondary endpoint. Overall, 790 patients were randomized to NIVO (526) vs PBO (264); 61% had stage IIB and 39% had stage IIC disease. Minimum follow-up was 8 months (median: 15.8 months NIVO; 15.9 months PBO); 66/526 (13%) vs 69/264 (26%) had a recurrence event. At this interim analysis, CheckMate 76K met the primary endpoint: NIVO significantly reduced the risk of recurrence vs PBO (stratified HR, 0.42; 95% CI, 0.30-0.59; stratified P<0.0001); 12-month RFS rates for NIVO vs PBO were 89% (95% CI, 86-92) vs 79% (74-84); substage rates were 93% vs 84% (IIB) and 84% vs 72% (IIC). RFS benefit was observed across predefined subgroups. For NIVO, 5% of all patients had distant recurrences and 2% regional; for PBO, it was 12% and 8%. Grade 3-4 treatment-related adverse events (TRAEs) for NIVO vs PBO were 10% vs 2%; any-grade TRAEs leading to discontinuation were 15% vs 3%. There was one treatment-related death (0.2%) with NIVO (heart failure and acute kidney injury). Adjuvant NIVO significantly improved RFS vs PBO and decreased the risk of recurrence or death by 58% in patients with resected stage IIB/C melanoma, with efficacy benefit across subgroups. The safety results were similar to the known anti–PD-1 monotherapy profile with no new safety signals. NIVO is an effective adjuvant treatment option with a clinically meaningful benefit in resected stage IIB/C melanoma. Encore presentation from Society of Melanoma Research, September 2022.
Genomic Profiling of Lentigo Maligna within an Interim Registry Analysis​
Authors: Stevens Greg , Rock James , Jansen Burkhard , Arnold Terry , Wood Jennifer , Clarke Loren , Hyde Mark
Published: March 2023

Background:  Pigmented lesion analysis remains a challenging aspect of dermatology. The DermTech Melanoma Test (‘the test’) is a non-invasive genomic test designed to rule-out melanoma. It consists of the pigmented lesion assay, which detects RNA products of Long Intergenic Non-Coding RNA 00518 (LINC00518) and Preferentially Expressed Antigen in Melanoma (PRAME), and an add-on assay for DNA promoter mutations in telomerase reverse transcriptase (TERT).  In previous studies, the test was found to have a negative predictive value ≥99%. This interim analysis of a registry study examines the genomic patterns of the Lentigo Maligna (LM) subtype of melanoma.  
Methods: Between April 2021 and March 2022, multiple geographically diverse sites throughout the US submitted data to a registry to assess real-world use of the test. Approximately 8,000 clinically atypical lesions were tested. After receiving the test result, providers followed their clinical judgement for biopsy decision. Histopathologic diagnoses for biopsied lesions were correlated with test results and all melanomas were sorted into LM subtype vs non-LM subtype. In addition, lesions that were noted to be on sun exposed skin and/or noted to have solar elastosis and called atypical melanocytic hyperplasia were included. 
Results: At the 1-year mark of the registry, there were roughly 8000 unique entries.  Of those, 1003 expressed one or more genomic markers from the DMT and had records available, and 134 (13.2%) were found to be melanoma or melanoma in-situ. More than a third (n=46, 34.3%) of the melanomas were of the Lentigo Maligna sub-type, with 7 of those being Lentigo Maligna Melanoma (LMM). Seven additional lesions were called atypical junctional melanocytic hyperplasia (AJMH) on sun-damaged skin. This group of 53 LM, LMM, and AJMH lesions were all evaluated for correlations to the DMT markers. LINC was the most commonly expressed genomic marker (n=45, 84.9%), with PRAME (n=36, 67.9%) and TERT (n=24, 45.3%) following. Most invasive tumors (LMM) expressed all three markers (n=4) and all 7 expressed LINC. 
Conclusion: While the original validation study included the LM subtype, this interim registry analysis demonstrates real-world use of the DMT in assessing pigmented macules concerning for LM. Over 1/3 of the melanomas reported in the registry were LM subtypes. LINC had a higher correlation with the lentigo maligna subtype of melanoma and was present in all invasive tumors. While AJMH is considered borderline, it may be worthwhile in the clinical context to group AJMH lesions with LM due to similarities in treatment.
Non-Invasive Genomic Profiling in Pediatric Patients
Authors: Perry Allyson , Ruppenthal Danielle , Hill Kellie
Published: March 2023

Background:Pigmented lesions with clinical features suspicious for melanoma are not uncommon in pediatric patients. Evaluation of these lesions is complicated by the low prevalence of pediatric melanoma and challenges associated with performing biopsies in children. The DermTech Melanoma Test (‘the test’) is a non-invasive genomic test designed to rule out melanoma. It consists of the Pigmented Lesion Assay (PLA), which detects RNA gene expression of long intergenic non-coding RNA 00518 (LINC00518, or LINC) and preferentially expressed antigen in melanoma (PRAME), and an add-on assay for DNA promoter mutations in telomerase reverse transcriptase (TERT), which is performed if ordered and if sufficient genomic material is available. Patients younger than 18 years were not included in initial validation studies. In this analysis, we sought to compare genomic biomarker results between uncertain pigmented lesions from adult and pediatric patients.

Methods:De-identified samples submitted to the clinical lab for the test from May through October 2022 were used for this analysis. Genomic results were available for 36,377 samples. The anatomic locations of the lesions were categorized as head/neck, trunk, or extremities and compared between adult and pediatric patients. Positivity rates for the PLA (and each individual marker) and the TERT add-on assay were calculated for adults and patients younger than 18 years of age.

Results:The PLA was performed on 34,050 skin samples from adults and 2,327 samples from pediatric patients. There were no differences between adults and pediatric patients in anatomic location of the lesions tested. The proportion of PLA-positive samples was similar between adult (7.0%, n=2,393) and pediatric (8.0%, n=187) patients. Rates of biomarkers detected among PLA-positive adult and pediatric patient samples, respectively, were as follows: LINC only (31.4% vs 69.5%), PRAME only (45.5% vs 14.4%), LINC and PRAME (23.0% vs 16.0%). The TERT add-on assay was performed in 11,084 samples from adults and 613 samples from pediatric patients. Of these, TERT was positive in 830 (7.5%) adult and 3 (0.5%) pediatric patient samples.

Conclusions:This analysis provides new information about genomic profiling of uncertain pigmented lesions from pediatric patients. While overall PLA positivity rates were similar across adult and pediatric samples, the proportion positive only for LINC was more than two times higher in pediatric samples. Additionally, TERT promoter mutations were rarely detected in pediatric samples. Further investigation of the significance of LINC, PRAME, and TERT abnormalities in lesions from pediatric patients is ongoing.
Meckel’s diverticulitis with abscess presentation in an acute abdomen
Authors: Varaprasadvarma Pavankumar Suraparaju , Pawar Anjali , Kaginalkar Varsha Rote
Published: March 2023

The vitellointestinal/omphalomesenteric duct is embryonic structure connecting primary yolk sac to the embryonic midgut which obliterates by 10th week of gestation. It may persist or incompletely obliterate to form anomalies like Meckel’s diverticulum that is most common and is usually asymptomatic. Symptoms develop when Meckel’s diverticulum involves complications such as hemorrhage, inflammation, and perforation, or when it causes intussusception or bowel obstruction. The modalities useful in diagnosing it are ultrasonography (USG) and computed tomography (CT), USG being more easily available, and radiation free is the first modality useful to suspect these anomalies. It can mimic close differentials such as appendicitis and urachal anomalies. In this case report, a 12-year-old male child presented with recurrent periumbilical pain who was screened on USG was suspected Meckel’s diverticulitis with abscess; the same was confirmed on contrast CT scan and managed surgically. This case shows the importance of USG and radiologist’s suspicion of Vitellointestinal duct anomalies in diagnosing and its associated complications.
C-REACTIVE PROTEIN AS A MARKER OF CARDIOVASCULAR DISEASES, MALIGNANT NEOPLASMS AND MENTAL DISORDERS (LITERATURE REVIEW)
Authors:   Gomel State Medical University, Gomel, Belarus, Nikiforova O. L. , Galinovskaya N. V. ,   Gomel State Medical University, Gomel, Belarus, Kozlov A. Ye. ,   Gomel State Medical University, Gomel, Belarus
Published: March 2023

The article presents up-to-date information on the structure of C-reactive protein, its functions and role in risk stratification of cardiovascular diseases, cancer and mental disorders.
NUMERICAL CALCULATION OF THE EFFECTIVE COEFFICIENT IN THE PROBLEM OF LINEAR ELASTICITY OF A COMPOSITE MATERIAL
Authors: Захаров П.Е. , Сивцев П.В.
Published: March 2023

Рассмотрен численный расчет эффективного коэффициента задачи линейной упругости композитного материала на отдельном представительном элементе, имеющем аналогичную объемную долю фибр. Полученный эффективный коэффициент используются для решения полной задачи на грубой сетке. В качестве примера рассматривается задача расчета деформации бетонного блока с включением стальных фибр под действием трехточечного изгиба. Вычислительная реализация задачи проводится методом конечных элементов с использованием вычислительной платформы FEniCS.

We consider the numerical calculation of the effective coefficient of the linear elasticity problem on a representative volume element having a similar volume fraction of fibers. The obtained effective coefficient is used to solve the complete problem on a coarse grid. As an example, the problem of calculating the deformation of a concrete block with the inclusion of steel fibers under the action of a three-point bending is considered. The computational implementation of the problem is carried out by the finite element method using the FEniCS computing platform.
NUMERICAL METHOD FOR SOLVING BOUNDARY INVERSE PROBLEM FOR ONE–DIMENSIONAL PARABOLIC EQUATION
Authors: Vasil’ev V.I. , Ling-De Su.
Published: March 2023

We consider a numerical method for solving boundary inverse problem using the implicit difference scheme for approximation by time and finite difference method for the boundary inverse problem. A numerical solution to the boundary inverse problem is determined by special decomposition which transforms the problem into two standard problems. We present the results of numerical experiments, including those with random errors in the input data, which confirm the capabilities of the proposed computational algorithms for solving this boundary inverse problem.
MODELING OF PARTICLE MOTION IN SPIRAL PNEUMOSEPARATOR BY STATISTICAL METHODS
Authors: Крылатова С.Р. , Матвеев А.И. , Лебедев И.Ф. , Яковлев Б.В.
Published: March 2023

При математическом моделировании процессов, происходящих в устройствах обогащения полезных ископаемых, появляются задачи определения вероятности местонахождения частицы на рабочих поверхностях устройств. В настоящей работе для решения подобной задачи предлагается статистический подход, т. е. при определении вероятности используется идея метода Гиббса. Рассмотрены проблемы моделирования процессов, происходящих в воздушном винтовом сепараторе. Разработаны математическая модель винтовой поверхности пневмосепаратора, модели движения частицы, потока невзаимодействующих частиц по рабочей поверхности сепаратора и алгоритм определения концентрации потока частиц. Рассчитанное распределение концентрации невзаимодействующих частиц на рабочей поверхности устройства отождествляется с распределением вероятности местонахождения одной частицы. Разработанный алгоритм определения вероятности положения частицы на рабочей поверхности пневмосепаратора может быть использован как элемент более сложной математической модели, например модели, где учитываются взаимодействия между частицами.

In mathematical modeling of mineral processing, there arise problems of determining the probability of the particle presence on the working surfaces of devices. In the paper, we propose a statistical approach to solving such problem, i. e., the idea of the Gibbs method is used. We consider problems of modeling processes in an air spiral separator. A mathematical model of the spiral surface of a pneumoseparator, a model of particle motion, a flux of noninteracting particles along the separator working surface, and an algorithm for determining the particle flux concentration are developed. The calculated distribution of the noninteracting particles concentration on the working surface of the device is identified with the probability distribution of the location of one particle. The developed algorithm for determining the probability of position of a particle on the working surface of the pneumoseparator can be used as an element of a more complex mathematical model, for example, a model where interactions between particles are taken into account.
ON SOME APPLICATIONS OF THE HYPERBOLIC HEAT EQUATION AND THE METHODS FOR SOLVING IT
Authors: Ханхасаев В.Н. , Дармахеев Э.В.
Published: March 2023

Создание новых технологических процессов, основанных на использовании высокоинтенсивных потоков энергии, вынуждает при определении температурного состояния учитывать конечную скорость распространения тепла. Этот учет может быть осуществлен при помощи гиперболического уравнения теплопроводности, полученного А. В. Лыковым в рамках неравновесной феноменологической термодинамики как следствие обобщения закона Фурье для потоков и уравнения теплового баланса. В прежних работах В. Н. Ханхасаева моделировался процесс коммутационного отключения электрической дуги в спутном потоке газа с использованием этого уравнения. В данной работе развивается математическая модель этого процесса с добавлением периода устойчивого горения дуги до момента отключения, и заменой строго гиперболического уравнения теплопроводности гиперболо-параболическим. Для полученного смешанного уравнения теплопроводности корректно поставлены и численно решаются ряд краевых задач в программных средах Фортран и Маткад с получением полей температур, хорошо согласующихся с имеющимися экспериментальными данными.

Creation of new technological processes based on the use of high-intensity energy fluxes makes it necessary to take into account the final rate of heat propagation when determining the temperature state. This account can be realized with the help of the hyperbolic heat equation obtained by A. V. Lykov in the framework of nonequilibrium phenomenological thermodynamics as a consequence of the generalization of the Fourier law for flows and the heat balance equation. In the previous works by V. N. Khankhasaev, the process of switching off the electric arc in a spiral gas flow was simulated using this equation. In this paper, a mathematical model of this process is developed with the addition of a period of steady burning of the arc until the moment of disconnection and replacement of the strictly hyperbolic heat conduction equation by a hyperbolic-parabolic equation. For the resulting mixed heat conduction equation, a number of boundary value problems in the Fortran and Matcad software environments are correctly posed and numerically solved, obtaining temperature fields that are in good agreement with the available experimental data.
ON A NON-LOCAL PROBLEM FOR MIXED HYPERBOLIC-PARABOLIC EQUATIONS
Authors: Хубиев К.У.
Published: March 2023

Для модельного уравнения смешанного гиперболо-параболического типа с нагруженным слагаемым в параболической части исследована нелокальная задача с внутреннекраевыми условиями в гиперболической части области.

A non-local boundary value problem with inner boundary conditions in its hyperbolic part is studied for loaded mixed hyperbolic-parabolic equations.
NUMERICAL MODELING OF THERMOELASTICITY PROBLEMS FOR CONSTRUCTIONS WITH INNER HEAT SOURCE
Authors: Васильева М.В. , Захаров П.Е. , Сивцев П.В. , Спиридонов Д.А.
Published: March 2023

Рассматривается численное моделирование термомеханического состояния конструкции, состоящего из источника тепла, газового зазора и оболочки. Математическая модель описывается нелинейной системой уравнений для температуры и перемещений. Выделение тепла происходит в подобласти источника. Возникающие перемещения за счет градиента температур рассчитываются в области источника и отдельно в оболочке и могут быть описаны как моделями линейной упругости, так и нелинейными моделями пластичности. Численная реализация построена на основе метода конечных элементов. Представлены результаты численного моделирования нелинейной модельной задачи в двумерной и трехмерной областях.

We consider the numerical simulation of the thermomechanical state of a structure consisting of a heat source, a gas gap and a shell. The mathematical model is described by a nonlinear system of equations for temperature and displacements. The heat is released in the subdomain of the heat source. The resulting displacements due to the temperature gradient are calculated in the heat source region and separately in the shell, and can be described by both linear elasticity models and nonlinear plasticity models. The numerical implementation is based on the finite element method. The results of numerical modeling of a nonlinear model problem in two- and three-dimensional domains are presented.
NUMERICAL RECOVERING OF LEADING COEFFICIENT OF NONLINEAR PARABOLIC EQUATION
Authors: Иванов Д.Х.
Published: March 2023

Численно восстанавливается старший коэффициент параболического уравнения в многомерной области. Рассматривается случай, когда старший коэффициент зависит только от решения, и в качестве дополнительного условия берутся данные в некоторых внутренних точках области. Для численного решения задачи используется метод конечных элементов и библиотека FEniCS. Приведены примеры идентификации старшего коэффициента двумерного параболического уравнения.

We numerically recover the leading coefficient of one parabolic equation in a multidimensional region. We consider the case when the leading coefficient depends only on solution itself and observations are taken in some interior points of the region as an additional condition. Finite element method implemented by FEniCS library is used for numerical solution of the problem. Several examples of identification of the leading coefficient of a two-dimensional parabolic equation are given.
MIXED MULTISCALE FINITE ELEMENT METHOD FOR PROBLEMS IN PERFORATED MEDIA WITH INHOMOGENEOUS
Authors: Бубякин И.В.
Published: March 2023

Статья посвящена дифференциальной геометрии подмногообразий многообразий G(m, n), m-мерных плоскостей проективного пространства $P^n$, содержащих конечное число торсов. Для исследования таких подмногообразий используется грассманово отображение многообразия G(m, n) m-мерных плоскостей проективного пространства $P^n$ на (m+1)(n−m)-мерное алгебраическое многообразие $\Omega(m, n)$ пространства $P^N$, где $N=\left(\begin{array}{c}m+1\\n+1\\\end{array}\right)-1$. Это отображение в сочетании с методом внешних форм Э. Картана и методом подвижного репера позволило определить зависимость строения изучаемых многообразий и конфигурации (m − 1)-мерных характеристических плоскостей и (m+ 1)-мерных касательных плоскостей торсов, принадлежащих рассматриваемым многообразиям.

We consider the projective differential geometry of m-dimensional plane submanifolds of manifolds G(m, n) in projective space $P^n$ containing a finite number of developable surfaces. To study such submanifolds we use the Grassmann mapping of manifolds G(m, n) of m-dimensional planes in projective space $P^n$ to $(m + 1)(n-m)$-dimensional algebraic manifold $\Omega(m, n)$ of space $P^N$, where $N=\left(\begin{array}{c}m+1\\n+1\\\end{array}\right)-1$. This mapping combined with the method of external Cartan’s forms and moving frame method made it possible to determine the dependence of considered manifolds structure and the configuration of the (m − 1)-dimensional characteristic planes and (m + 1)-dimensional tangential planes of developable surfaces that belong to considered manifolds.
Boundary control for a pseudo-parabolic equation
Authors: Фаязова З.К.
Published: March 2023

Ранее была рассмотрена задача: на части границы области Ω ⊂ R3 находится нагреватель, имеющий регулируемую температуру. Требуется найти такой режим работы нагревателя, чтобы средняя температура в некоторой подобласти D области Ω принимала заданное значение. В данной работе рассматривается аналогичная задача граничного управления связанная с псевдопараболическим уравнением на отрезке. На части границы рассматриваемого отрезка задается значение решения, которое содержит параметр управления. Ограничение для допустимого управления задано в таком виде, что среднее значение решения в некоторой части рассматриваемого отрезка принимает заданное значение. Решается вспомогательная задача методом разделения переменных. Искомая задача сводится к интегральному уравнению Вольтерра второго рода. Методом преобразования Лапласа доказываются теоремы о существовании и единственности допустимого управления.

Previously, a mathematical model for the following problem was considered. On a part of the border of the region Ω ⊂ R3 there is a heater with controlled temperature. It is required to find such a mode of its operation that the average temperature in some subregion D of Ω reaches some given value. In this paper, we consider a similar boundary control problem associated with a pseudo-parabolic equation on a segment. On the part of the border of the considered segment, the value of the solution with control parameter is given. Restrictions on the control are given in such a way that the average value of the solution in some part of the considered segment gets a given value. The auxiliary problem is solved by the method of separation of variables, while the problem in consideration is reduced to the Volterra integral equation of the second kind. By Laplace transform method, the existence and uniqueness theorems for admissible control are proved.
About the absolute value function with different nodes of Lagrange interpolation
Authors: Хохолов В.Б.
Published: March 2023

Рассматриваются интерполяционные процессы Лагранжа по следующим матрицам узлов интерполирования: матрица по корням многочлена Чебышева I-го рода; матрица по корням многочлена Лежандра; расширенная матрица по корням многочлена Лежандра. Для этих матриц доказаны равномерная сходимость процесса Лагранжа при интерполировании функции модуль числа. Получены оценки порядка сходимости для каждой из этих матриц узлов. Для улучшения качества сходимости к матрице по корням Лежандра в качестве узлов были добавлены и концы отрезка. При этом для функции модуль числа порядок сходимости процесса Лагранжа не меняется, а лишь улучшается примерно в 8 раз. Для сравнения приводится отрицательный результат и по матрице равноотстоящих узлов.

Lagrange interpolation processes are considered for the following matrixes of interpolation nodes: the matrix of Chebyshev polynomial roots of the 1st kind, the matrix of Legendre polynomials roots, and the extended matrix of Legendre polynomials roots. For these matrixes the uniform convergence of Lagrange process of interpolation for the absolute value function proved. Also, we receive estimates on the order of convergence for each of these matrixes. To ensure the quality of convergence, the endpoints of the segment were added as nodes to the matrix of Legendre roots. However, for the absolute value function the order of convergence of the Legendre process does not change, but improves by approximately 8 times. For comparison, the negative result of equidistant nodes is taken.