bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinimetric methods for evaluating patients with Parkinson's disease in the context of the latest treatment strategies
Authors: Pawłowski Piotr , Ziętara Karolina , Orzechowska Aleksandra , Pawlina Mateusz , Pawełczak Natalia , Oskroba Aleksander , Stawikowski Cezary , Raksa Karolina , Kowalczyk Ilona , Zielonka Bartłomiej
Published: March 2023

Background: Parkinson's disease is a neurodegenerative disease involving the deposition of alpha-synuclein deposits in dopaminergic neurons of the black matter, resulting in a decrease in dopamine levels in the central nervous system and the development of motor and non-motor symptoms. Aim of the study: This study aims to identify clinimetric methods for evaluating patients with Parkinson's disease in the context of contemporary therapies. Material and methods: English-language scientific literature from 2012 - 2022 from databases such as PubMed, SCOPUS, Web of Science, Google Scholar was reviewed. Searches were conducted according to keywords: Parkinson's disease, clinical evaluation, and treatment methods. 69 items of literature were qualified for analysis. Results and conclusions: The diagnosis of Parkinson's disease is a diagnosis by exclusion, there are no available and inexpensive methods to diagnose the disease with certainty. The clinimetric assessment of the patient is therefore the basis not only for diagnosis but also for effective, tailored treatment. There are many assessment tools dedicated to patients with this disease entity, and these are the ones recommended for this process. Contemporary treatment methods, especially for those in whom the effectiveness of pharmacological treatment is unsatisfactory, include deep brain stimulation, enteral infusion of DuoDopa®, and subcutaneous infusion/injections of apomorphine. The inclusion of the techniques depends mainly on the assessed condition of the patient.
The co-construction of empathic communication in interpreter-mediated medical consultations: A qualitative analysis of interaction
Authors: Theys Laura , Wermuth Cornelia , Salaets Heidi , Pype Peter , Krystallidou Demi
Published: March 2023

Current interpreter training programs pay increasingly more attention to the intricacies of the clinical context, such as doctors and patients’ communicative goals. However, to date, the conduit model remains influential when it comes to interpreters dealing with other participants’ emotions and their own emotions in interpreter-mediated consultations (IMCs). Consequently, establishing a good doctor-patient relationship by means of empathic communication (EC) might be jeopardized in IMCs. During EC, patients express their emotional or illness experiences to which doctors convey their empathic understanding. This study aimed to assess how doctors, patients, and interpreters verbally co-construct EC and the interpreter’s effect on this process. We analyzed 7 authentic IMCs using the Empathic Communication Coding System, as previously adapted for IMCs. We identified empathic opportunities (EOs) and empathic responses (ERs) as expressed by patients/doctors, and as rendered by interpreters. Our results showed that EC is the result of an interactive and collaborative process among all participants in IMCs. That is, the interplay between participants’ communicative actions determines how patients’ expressed lived experiences are addressed in IMCs. Our findings suggest that interpreters hold a central position in this process as they initiated EC about the patient’s illness experience and exerted control over the ways in which statements were rendered (e.g., interpreters omitted and altered original statements). In addition, our results indicated that EC in IMCs might be compromised by doctors and interpreters’ communicative actions.
Linguacultural isomorphism / anisomorphism and synesthetic metaphor translation procedures
Authors: Zhulavska Olha , Martynyuk Alla
Published: March 2023

In this paper, we combine analytical tools of conceptual metaphor theory with the affordances of corpus-based linguistics and quantitative analysis to investigate the translation of synesthetic metaphors found in Donna Tartt’s novels into Ukrainian. A synesthetic metaphor is addressed as a linguistic expression representing a sensation of one modality in terms of another. We claim that the choice of a translation procedure – retention, removal, omission, modification, or addition is partly determined by linguacultural similarity (i.e. isomorphism) or specificity (i.e. anisomorphism) of cross-sensory mappings that underlie the source-text and targettext linguistic expressions and partly – by the translator’s free choice, which cannot be explained by objective reasons. The obtained results show the following trends. Original metaphors as well as conventional metaphors based on isomorphic crosssensory mappings are mostly retained. Conventional metaphors that rest on anisomorphic mappings are mostly modified or removed/omitted. However, the translator can choose to remove/modify a synesthetic metaphor that rests on an isomorphic mapping. Added synesthetic metaphors usually root in isomorphic mappings. The applied methodology minimizes subjectivity of judgment in differentiating between the compulsory (i.e. imposed by the linguacultural specificity) and free strategic choices, which contributes to the potential impact of this research.
Do cercamento das terras comuns ao Estatuto da Cidade: a colonialidade do direito de propriedade como obstáculo para a efetivação do direito à cidade no Brasil
Authors: Alfonsin Betânia De Moraes , Segat Flávia , Gallicchio Juliana Raffaela de Souza , Montanari Vitória
Published: March 2023

Completados vinte anos do Estatuto da Cidade, o presente artigo pretende discutir em que medida o estatuto jurídico do direito de propriedade – apesar de alterado pela Lei nº 10.257/01, mas mantido, em essência, como centro da ordem urbanística – representou um entrave para o cumprimento das funções sociais da cidade e para a efetivação do direito à cidade. A análise se debruça sobre como o direito de propriedade se faz presente na lei, por meio do exame (i) da função social da propriedade, (ii) dos instrumentos de combate à retenção especulativa de imóveis, (iii) do instituto do plano diretor e (iv) da usucapião urbana especial para fins de moradia. O método de abordagem é dialético e o método de procedimento é histórico, já que a reconstituição da forma pela qual a propriedade foi introduzida no Brasil é realizada para demonstrar que a resiliência de tal instituto, mesmo em uma lei como o Estatuto da Cidade, é uma manifestação da colonialidade do poder. Em um exercício propositivo de alternativas para uma saída dessa armadilha jurídica e epistêmica, a pesquisa realizada analisa as discussões sobre os comuns, sobre função social da posse, sobre o termo territorial coletivo e sobre as potencialidades das ZEIS.
Perspectiva libertária da intervenção do Estado no Brasil: a inovação como questão
Authors: Coimbra Elisa Mara
Published: March 2023

O artigo analisa criticamente as aplicações da teoria libertária de Robert Nozick à intervenção do Estado na Economia. Para isso, primeiramente, examina-se a construção filosófica da teoria libertária, em especial as interações sociais que originaram o Estado mínimo. A partir de um contraexemplo ao caminho lógico-racional do autor, estabelece-se uma nova linha dedutiva, hábil a reinterpretar o desenvolvimento do Estado após o Estado mínimo. Para isso, utiliza-se o método dedutivo para validar a hipótese de que o Estado brasileiro pode se expandir além do mínimo sem violar direitos e restrições morais, utilizando as mesmas premissas iniciais formuladas por Nozick (1988). Neste caso, o exemplo discutido é a possibilidade de o Estado fomentar a inovação tecnológica por meio de políticas públicas.
A diáspora dos trabalhadores dos países industrializados rumo aos países em desenvolvimento e do terceiro mundo: a revolução laboral do século XXI
Authors: Mesquita Lurdes Varregoso , Machado Maria João , Fernandes Maria Malta , Azevedo Patrícia Anjos , Tomás Sérgio Tenreiro , Machado Susana Sousa
Published: March 2023

Os nómadas digitais são trabalhadores que desenvolvem a sua atividade profissional com recurso à Internet, não sendo obrigados a comparecer pessoalmente. O nosso objetivo é analisar este fenómeno.O nosso objetivo será alcançado com uma análise jurídica e doutrinária, que é nossa metodologia.Como resultado, verificamos que o nomadismo digital na esfera do contrato de trabalho irá explodir nos próximos anos, não só graças à evolução da tecnologia e ao facto de vivermos num mundo cada vez mais global, mas também como resultado da pandemia causada pela doença de Covid-19. Dentro deste espectro, somam-se as vantagens para o trabalhador, no sentido de poder desempenhar as suas funções laborais em países onde a economia, os aspetos fiscais, familiares ou mesmo o clima lhe permitirão adquirir mais bens e serviços por menos dinheiro. Na perspetiva das empresas, abre-se também a oportunidade de recrutar mão de obra estrangeira ou deslocalizada.Neste contexto, importa salientar, como conclusão, no que respeita ao nomadismo digital dentro dos países que constituem a União Europeia e que constituem o mercado comum europeu, que seria salutar que o legislador europeu tivesse a coragem de dinamizar o nomadismo digital.
Synthesis of Silver Nanoparticles Using Novel Chemical Solution Method as Antibacterial Applied on Cosmetic Cotton Balls
Authors: Mahgoub Sizam A. M. , Karahan M. , Elsanosi Hind A. M. , A. Bader Malaz S. , O. Mohamed Sitana H. , Mohamed Ahmed Hasabo Abdelbagi , Ari A.
Published: March 2023

This research aimed at preparing silver nanoparticles using the Novel chemical method, obtained as a black precipitate silver NPs. The sample was examined by using digital spectrometer device to find a degree of absorbency and its wavelength and particle by mathematical equation. Microbiology tests were carried out to determine the effectiveness of the sample in killing bacteria using the dilution method. After dissolving Silver NP`S in 5% acetic acid concentration, and covering the cotton balls with a solution of silver NPs to test the effectiveness of the sample using Two different concentrations of (0.5ml/g), and (0.25ml/g) and using two types of bacteria which causes skin blisters staphylococcus and streptococcus it is found that more concentration of the silver NPs solution has increased of killing both types of bacteria by staphylococcus (100%) and streptococcus (75%).
Preoperative vascular assessment of patients with a supracondylar humeral fracture and a perfused, pulseless limb
Authors: Holme Thomas J. , Crate Georgina , Trompeter Alex J. , Monsell Fergal P. , Bridgens Anna , Gelfer Yael
Published: March 2023

Aims

The ‘pink, pulseless hand’ is often used to describe the clinical situation in which a child with a supracondylar fracture of the humerus has normal distal perfusion in the absence of a palpable peripheral pulse. The management guidelines are based on the assessment of perfusion, which is difficult to undertake and poorly evaluated objectively. The aim of this study was to review the available literature in order to explore the techniques available for the preoperative clinical assessment of perfusion in these patients and to evaluate the clinical implications.

Methods

A systematic literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registered prospectively with the International Prospective Register of Systematic Reviews. Databases were explored in June 2022 with the search terms (pulseless OR dysvascular OR ischaemic OR perfused OR vascular injury) AND supracondylar AND (fracture OR fractures).

Results

A total of 573 papers were identified as being suitable for further study, and 25 met the inclusion criteria for detailed analysis. These studies included a total of 504 patients with a perfused, pulseless limb associated with a supracondylar humeral fracture. Clinical examination included skin colour (23 studies (92%)), temperature (16 studies (64%)), and capillary refill time (13 studies (52%)). Other investigations included peripheral oxygen saturation (SaO2) (six studies (24%)), ultrasound (US) (14 (56%)), and CT angiogram (two studies (8.0%)). The parameters of ‘normal perfusion’ were often not objectively defined. The time to surgery ranged from 1.5 to 12 hours. A total of 412 patients (82%) were definitively treated with closed or open reduction and fixation, and 92 (18%) required vascular intervention, ranging from simple release of entrapped vessels to vascular grafts.

Conclusion

The description of the vascular assessment of the patient with a supracondylar humeral fracture and a pulseless limb in the literature is variable, with few objective criteria being used to define perfusion. The evidence base for decision-making is limited, and further research is required. We were able, however, to make some recommendations about objective criteria for the assessment of these patients, and we suggest that these are performed frequently to allow the detection of any deterioration of perfusion.

Cite this article: Bone Joint J 2023;105-B(3):231–238.
A comparison of clinical thresholds for revision following total and unicompartmental knee arthroplasty
Authors: Tay Mei L. , Monk A. P. , Frampton Christopher M. , Hooper Gary J. , Young Simon W.
Published: March 2023

Aims

Unicompartmental knee arthroplasty (UKA) has higher revision rates than total knee arthroplasty (TKA). As revision of UKA may be less technically demanding than revision TKA, UKA patients with poor functional outcomes may be more likely to be offered revision than TKA patients with similar outcomes. The aim of this study was to compare clinical thresholds for revisions between TKA and UKA using revision incidence and patient-reported outcomes, in a large, matched cohort at early, mid-, and late-term follow-up.

Methods

Analyses were performed on propensity score-matched patient cohorts of TKAs and UKAs (2:1) registered in the New Zealand Joint Registry between 1 January 1999 and 31 December 2019 with an Oxford Knee Score (OKS) response at six months (n, TKA: 16,774; UKA: 8,387), five years (TKA: 6,718; UKA: 3,359), or ten years (TKA: 3,486; UKA: 1,743). Associations between OKS and revision within two years following the score were examined. Thresholds were compared using receiver operating characteristic analysis. Reasons for aseptic revision were compared using cumulative incidence with competing risk.

Results

Fewer TKA patients with ‘poor’ outcomes (≤ 25) subsequently underwent revision compared with UKA at six months (5.1% vs 19.6%; p < 0.001), five years (4.3% vs 12.5%; p < 0.001), and ten years (6.4% vs 15.0%; p = 0.024). Compared with TKA, the relative risk for UKA was 2.5-times higher for ‘unknown’ reasons, bearing dislocations, and disease progression.

Conclusion

Compared with TKA, more UKA patients with poor outcomes underwent revision from early to long-term follow-up, and were more likely to undergo revision for ‘unknown’ reasons, which suggest a lower clinical threshold for UKA. For UKA, revision risk was higher for bearing dislocations and disease progression. There is supporting evidence that the higher revision UKA rates are associated with lower clinical thresholds for revision and additional modes of failure.

Cite this article: Bone Joint J 2023;105-B(3):269–276.
Impaction procedure influences primary stability of acetabular press-fit components
Authors: Ruhr Miriam , Huber Gerd , Niki Yasaman , Lohner Larissa , Ondruschka Benjamin , Morlock Michael M.
Published: March 2023

Aims

The aim of the study was to investigate whether the primary stability of press-fit acetabular components can be improved by altering the impaction procedure.

Methods

Three impaction procedures were used to implant acetabular components into human cadaveric acetabula using a powered impaction device. An impaction frequency of 1 Hz until complete component seating served as reference. Overimpaction was simulated by adding ten strokes after complete component seating. High-frequency implantation was performed at 6 Hz. The lever-out moment of the acetabular components was used as measure for primary stability. Permanent bone deformation was assessed by comparison of double micro-CT (µCT) measurements before and after impaction. Acetabular component deformation and impaction forces were recorded, and the extent of bone-implant contact was determined from 3D laser scans.

Results

Overimpaction reduced primary acetabular component stability (p = 0.038) but did not significantly increase strain release after implantation (p = 0.117) or plastic deformations (p = 0.193). Higher press-fits were associated with larger polar gaps for the 1 Hz reference impaction (p = 0.002, R2 = 0.77), with a similar trend for overimpaction (p = 0.082, R2 = 0.31). High-frequency impaction did not significantly increase primary stability (p = 0.170) at lower impaction forces (p = 0.001); it was associated with smaller plastic deformations (p = 0.035, R2 = 0.34) and a trend for increased acetabular component relaxation between strokes (p = 0.112). Higher press-fit was not related to larger polar gaps for the 6 Hz impaction (p = 0.346).

Conclusion

Overimpaction of press-fit acetabular components should be prevented since additional strokes can be associated with increased bone damage and reduced primary stability as shown in this study. High-frequency impaction at 6 Hz was shown to be beneficial compared with 1 Hz impaction. This benefit has to be confirmed in clinical studies.

Cite this article: Bone Joint J 2023;105-B(3):261–268.
A NEW SOLUTION FOR INCOMPLETE AHP MODEL USING GOAL PROGRAMMING AND SIMILARITY FUNCTION
Authors: Maryam Bagheri Fard Sharabiani  , Gholamian Mohammad Reza Gholamian , Seyed Farid Ghannadpour
Published: March 2023

The pairwise comparison matrix (PCM) is a crucial element of the Analytic Hierarchy Process (AHP). In many cases, the PCM is incomplete and this complicates the decision-making process. Hence, the present study offers a novel approach for dealing with incomplete information in group decision-making. We present a new model of incomplete AHP using goal programming (GP) and the similarity function. The minimization of this similarity function reduces errors in decision-making. The proposed model will be able to estimate the unknown elements in the pairwise comparison matrix and calculate the weight vectors obtained from the matrices. Several examples are implemented to elaborate on the estimation of unknown elements and weight vectors in the proposed model. The results show that the unknown elements have an acceptable value with an appropriate consistency rate.
Polarized-depolarized Rayleigh scattering for simultaneous composition and temperature measurements in non-isothermal gaseous mixtures
Authors: Chakravarthy Kharthik , Le Page Laurent M. , Williams Benjamin A. O.
Published: March 2023

This paper demonstrates the application of polarized-depolarized
Rayleigh scattering (PDRS) as a simultaneous mixture fraction and
temperature diagnostic for non-reacting gaseous mixtures. Previous
implementations of this technique have been beneficial when used for
combustion and reacting flow applications. This work sought to extend
its applicability to non-isothermal mixing of different gases. The use
of PDRS shows promise in a range of applications outside combustion,
such as in aerodynamic cooling technologies and turbulent heat
transfer studies. The general procedure and requirements for applying
this diagnostic are elaborated using a proof-of-concept experiment
involving gas jet mixing. A numerical sensitivity analysis is then
presented, providing insight into the applicability of this technique
using different gas combinations and the likely measurement
uncertainty. This work demonstrates that appreciable signal-to-noise
ratios can be obtained from this diagnostic in gaseous mixtures,
yielding simultaneous temperature and mixture fraction visualization,
even for an optically non-optimal selection of mixing species.
High-Q chalcogenide racetrack resonators based on the multimode waveguide
Authors: Wang Zhiyuan , Yang Zhen , Wang Haoxian , Zhang Wei , Wang Rongping , Xu Peipeng
Published: March 2023

We propose and demonstrate a high quality (Q) factor racetrack resonator based on uniform multimode waveguides in high-index contrast chalcogenide glass film. Our design features two carefully designed multimode waveguide bends based on modified Euler curves, which enable a compact 180° bend and reduce the chip footprint. A multimode straight waveguide directional coupler is utilized to couple the fundamental mode without exciting higher-order modes in the racetrack. The fabricated micro-racetrack resonator shows a record-high intrinsic Q of 1.31×106 for selenide-based devices, with a relatively low waveguide propagation loss of only 0.38 dB/cm. Our proposed design has potential applications in power-efficient nonlinear photonics.
Fiber coupling efficiency in ocean with adaptive optics corrections
Authors: Gökçe Muhsin Caner , Ata Yalçın , Baykal Yahya
Published: March 2023

Underwater optical wireless communication (UOWC) is a very promising technology that enables high-speed data transfer through the use of laser beams in an oceanic turbulent medium. The high-tech fiber optical devices, which are already available in the market, can be integrated with the UOWC systems. When integration is achieved, oceanic turbulence, which distorts the wavefront of the propagating laser beam, plays an important role in reducing the fiber coupling efficiency (FCE), which in turn results in reducing the light power received from the fiber optical components. In this paper, we propose the use of the adaptive optics technique in a UOWC system to mitigate the effects of oceanic turbulence and boost the FCE. For this reason, the field correlation for a Gaussian laser beam is derived by using the Huygens–Fresnel principle. This way, the light power over the coupling lens and the light power accepted by the fiber core are formulated under the effect of adaptive optics corrections, which are represented by the number of Zernike modes. The results demonstrate that under the oceanic turbulence effect, the FCE of the UOWC system employing adaptive optics is always larger than that of the UOWC system employing no adaptive optics.
The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation
Authors: Ruthig Victor A. , Hatkevich Talia , Hardy Josiah , Friedersdorf Matthew B. , Mayère Chloé , Nef Serge , Keene Jack D. , Capel Blanche
Published: March 2023

DND1 is essential to maintain germ cell identity. Loss ofDnd1function results in germ cell differentiation to teratomas in some inbred strains of mice or to somatic fates in zebrafish. Using our knock-in mouse line in which a functional fusion protein between DND1 and GFP is expressed from the endogenous locus (Dnd1GFP), we distinguished two male germ cell (MGC) populations during late gestation cell cycle arrest (G0), consistent with recent reports of heterogeneity among MGCs. Most MGCs express lower levels of DND1-GFP (DND1-GFP-lo), but some MGCs express elevated levels of DND1-GFP (DND1-GFP-hi). A RNA-seq time course confirmed highDnd1transcript levels in DND1-GFP-hi cells along with 5-10-fold higher levels for multiple epigenetic regulators. Using antibodies against DND1-GFP for RNA immunoprecipitation (RIP)-sequencing, we identified multiple epigenetic and translational regulators that are binding targets of DND1 during G0 including DNA methyltransferases (Dnmts), histone deacetylases (Hdacs), Tudor domain proteins (Tdrds), actin dependent regulators (Smarcs), and a group of ribosomal and Golgi proteins. These data suggest that in DND1-GFP-hi cells, DND1 hosts coordinating mRNA regulons that consist of functionally related and localized groups of epigenetic enzymes and translational components.
The changing epidemiology of shigellosis in Australia, 2001–2019
Authors: Ibrahim Aaliya F. , Glass Kathryn , Williamson Deborah A. , Polkinghorne Benjamin G. , Ingle Danielle J. , Wright Rose , Kirk Martyn D.
Published: March 2023

Shigellosis is an increasing cause of gastroenteritis in Australia, with prolonged outbreaks reported in remote Aboriginal and Torres Strait Islander (hereafter “First Nations”) communities and among men who have sex with men (MSM) in major cities. To determine associations betweenShigellaspecies and demographic and geographic factors, we used multivariate negative binomial regression to analyse national case notifications of shigellosis from 2001 to 2019.

Between 2001 and 2019, Australian states and territories reported 18,363 shigellosis cases to the National Notifiable Diseases Surveillance System (NNDSS), of which age, sex and organism information were available for >99% (18,327/18,363) of cases. Of the cases included in our analysis, 42% (7,649/18,327) wereS.sonnei, 29% (5,267/18,327) wereS.flexneri, 1% (214/18,327) wereS.boydii, less than 1% (87/18,327) wereS.dysenteriae, and species information was unknown for 28% (5,110/18,327) of cases. Males accounted for 54% (9,843/18,327) of cases, and the highest proportion of cases were in children aged 0–4 years (19%; 3,562/18,327). Crude annual notification rates ranged from 2.2 cases per 100,000 in 2003 and 2011 to 12.4 cases per 100,000 in 2019. Nationally, notification rates increased from 2001 to 2019 with yearly notification rate ratios of 1.04 (95% CI 1.02–1.07) forS.boydiiand 1.05 (95% CI 1.04–1.06) forS.sonnei. Children aged 0–4 years had the highest burden of infection forS.flexneri,S.sonneiandS.boydii; and males had a higher notification rate forS.sonnei(notification rate ratio 1.24, 95% CI 1.15–1.33). First Nations Australians were disproportionately affected by shigellosis, with the notification rate in this population peaking in 2018 at 92.1 cases per 100,000 population. Over the study period, we also observed a shift in the testing method used to diagnose shigellosis, with culture independent diagnostic testing (CIDT) increasing from 2014; this also coincided with an increase in notifications of untypedShigella. This change in testing methodology may have contributed to the observed increase in shigellosis notifications since 2014, with CIDT being more sensitive than culture dependent testing methods.

The findings of this study provide important insights into the epidemiological characteristics of shigellosis in Australia, including identification of high-risk groups. This can be used to inform public health prevention and control strategies, such as targeted communication programs in First Nations communities and places with high levels of interaction between young children, such as childcare centres. Our study findings also highlight the implications of culture independent testing on shigellosis surveillance, particularly a reduction in the availability of species level information. This emphasises the continued importance of culture dependant testing for national surveillance of shigellosis.
RNA sequencing-based transcriptome analysis of granulosa cells from follicular fluid: Genes involved in embryo quality during in vitro fertilization and embryo transfer
Authors: Yu Eun Jeong , Choi Won Yun , Park Mi Seon , Eum Jin Hee , Lee Dong Ryul , Lee Woo Sik , Lyu Sang Woo , Yoon Sook Young
Published: March 2023

Background

Granulosa cells play an important role in folliculogenesis, however, the role of RNA transcripts of granulosa cells in assessing embryo quality remains unclear. Therefore, we aims to investigate that RNA transcripts of granulosa cells be used to assess the probability of the embryonic developmental capacity.

Methods

This prospective cohort study was attempted to figure out the probability of the embryonic developmental capacity using RNA sequencing of granulosa cells. Granulosa cells were collected from 48 samples in good-quality embryo group and 79 in only poor- quality embryo group from women undergoing in vitro fertilization and embryo transfer treatment. Three samples from each group were used for RNA sequencing.

Results

226 differentially expressed genes (DEGs) were related to high developmental competence of embryos. Gene Ontology enrichment analysis indicated that these DEGs were primarily involved in biological processes, molecular functions, and cellular components. Additionally, pathway analysis revealed that these DEGs were enriched in 13 Kyoto Encyclopedia of Genes and Genomes pathways. Reverse transcription quantitative polymerase chain reaction verified the differential expression of the 13 selected DEGs. Among them,10 genes were differently expressed in the poor-quality embryo group compared to good-quality embryo group, including CSF1R, CTSH, SERPINA1, CYP27A1, ITGB2, IL1β, TNF, TAB1, BCL2A1, and CCL4.

Conclusions

RNA sequencing data provide the support or confute granulosa expressed genes as non-invasive biomarkers for identifying the embryonic developmental capacity.
Understanding Gardar Sahlberg with neural nets: On algorithmic reuse of the Swedish SF archive
Authors: Eriksson Maria , Skotare Tomas , Snickars Pelle
Published: March 2023

In this article, we re-trace the history of the Swedish SF archive and reflect on how this collection of historic newsreels has been reappropriated and remixed throughout more recent media history. In particular, we focus on the work of director and film historian Gardar Sahlberg, who made extensive use of the SF archive, first in a series of documentary films, then in a number of historical TV programmes. We are interested in how historic film footage travels and circulates through time, but foremost we explore how algorithms can help identify instances of audio-visual reuse in large datasets. Hence the article discusses algorithmic ways of examining archival film reuse, introducing a method for mapping video reuse with the help of artificial intelligence or more precisely machine learning that uses so-called convolutional neural nets. The article presents the Video Reuse Detector (VRD), a tool that uses machine learning to identify visual similarities within a given audio-visual database such as the SF archive.
Os discursos do Turismo e o desafio da sua tradução
Authors: Carreira Vivina Almeida , Plag Cornelia , Carapinha Conceição
Published: March 2023

Este volume reúne oito textos que se situam na encruzilhada entre os estudos do Turismo e da Tradução, salientando os desafios que se colocam numa área marcada pelo contacto de culturas, línguas, discursos.
Os trabalhos aqui compilados abarcam diferentes línguas, diferentes perspetivas teóricas, diferentes géneros textuais, e problemas de tradução. Neste âmbito, destaca-se, como uma das linhas de força deste volume, a abordagem do Turismo e da Tradução no contexto português. Ressaltam ainda os estudos sobre temáticas específicas, como é o caso do turismo cultural, nomeadamente o enoturismo, sobre a comunicação das narrativas do Turismo em catálogos ou podcasts de viagem ou, ainda, a questão da acessibilidade aos bens culturais  e o papel que cabe à Tradução neste contexto.
Tooth segmentation in 3D cone-beam CT images using deep convolutional neural network
Authors: Khan Shahid , Mukati Altaf , Rizvi Syed Sajjad Hussain , Yazdanie Nazia
Published: March 2023

Segmentation of an individual tooth in dental radiographs has great significance in the process of orthodontics surgeries and dentistry. Machine learning techniques, especially deep convolutional neural networks can play a key role in revolutionizing the way orthodontics surgeons and dentists work. Lately, many researchers have been working on tooth segmentation in 3D volumetric dental scans with a great degree of success, but to the best of our knowledge, there is no pretrained neural network available publicly for performing tooth segmentation in 3D cone-beam dental CT scans. The methods which so far have been proposed by the researchers in this domain are based on complex multistep pipelines. This lack of the availability of a pre-trained model blocks the path for further explorations in this domain. In this research, we have produced a deep learning model for tooth segmentation from CBCT dental radiographs. The proposed model can segment teeth in CBCT scans in a single step. To train the proposed model, we obtained a dataset consisting of 70 3D CBCT volumes from a local health facility. We labeled the ground truth through a semi-automatic method and trained our neural network. The training yielded a validation accuracy of 95.57% on a binary class semantic segmentation of the 3D CBCT volumes. The model is successfully able to segment teeth, regardless of their type from the background in a single step. This eliminates the need of having a complex and lengthy pipeline which many researchers have been proposing. The proposed model can be extended by incorporating labeling schemes. The custom labeling schemes will help healthcare professionals to perform the labeling as per their needs. The produced model can also provide a basis for further research in this domain.
PLANOS DIRETORES E O CONTEXTO REGIONAL: EVIDÊNCIAS A PARTIR DOS DEZ MUNICÍPIOS MAIS POPULOSOS DE MINAS GERAIS
Authors: Diniz Alexandre Magno Alves
Published: March 2023

Este estudo parte da inquietação causada pela ausência de conteúdos regionais nos Planos Diretores de grande parte dos municípios mineiros. Visando a ilustrar a extensão dessas omissões, realizou-se uma análise dos Planos Diretores dos dez municípios mais populosos de Minas Gerais. Concomitantemente, analisaram-se os principais manuais de construção de Planos Diretores,  nos quais a presença de dimensões e indicadores que deveriam compor a construção de diagnósticos municipais foi identificada, com destaque para a capacidade institucional; cultura; desenvolvimento econômico; desenvolvimento social; dinâmica imobiliária; estrutura fundiária; evolução histórica da cidade/município; infraestrutura urbana; meio ambiente; população (mobilidade e circulação); saneamento; e uso do solo. Partindo da necessidade de incorporação do contexto regional dos municípios à construção dos Planos Diretores, este estudo analisa o potencial de utilização dos dados disponibilizados pelo Índice Mineiro de Responsabilidade Social (IMRS) na caracterização do contexto regional dos municípios mineiros, oferecendo uma cesta de indicadores produzidos e disponibilizados gratuitamente pela Fundação João Pinheiro. A adoção desses indicadores e o foco na perspectiva regional ampliarão sensivelmente o poder dos Planos Diretores, fazendo cumprir de modo mais assertivo os pressupostos presentes no Estatuto das Cidades.
COBERTURA DA TERRA E VARIÁVEIS LIMNOLÓGICAS EM CANAIS FLUVIAIS DA ZONA DE AMORTECIMENTO DO PARQUE ESTADUAL AGUAPEÍ, OESTE DO ESTADO DE SÃO PAULO
Authors: Correa Amanda Rodrigues , Rocha Paulo Cesar
Published: March 2023

O objetivo deste trabalho é analisar o uso e cobertura da terra e a sua influência sobre as características limnológicas em três canais fluviais localizados na zona de amortecimento do Parque Estadual do Aguapeí. As amostragens nas águas superficiais ocorreram em dezembro de 2018 e abril de 2019. As etapas realizadas consistiram em processar e analisar o uso e cobertura da terra por meio de mapas elaborados e análise de variáveis climatológicas na bacia de contribuição dos canais, assim como, análise de variáveis hidrológicas e limnológicas nos canais, as variáveis mensuradas foram analisadas a partir de ferramentas estatisticas como a análise de agrupamento. Os resultados demonstraram que as classes de uso de cultura temporária e vegetação natural podem influenciar em maior proporção as variáveis limnológicas pH, oxigênio dissolvido, temperatura da água, fósforo total e condutividade elétrica. As classes de solo exposto, área urbanizada/construída e agropastoril podem influenciar majoritariamente as concentrações do material em suspensão e suas frações. A partir dos resultados encontrados vale salientar a necessidade de melhorias que possam auxiliar o não agravamento de problemas ambientais que impactem aos recursos naturais no Parque Estadual do Aguapeí.
Urban Arenas for Sustainable and Just Cities
Authors: Crowley Duncan , Henfrey Tom
Published: March 2023

The experimental, academic project UrbanA, funded by the European Commission under Horizon 2020 from 2019 to 2021, investigated the topic of Sustainable and Just Cities. The project centred around four co-creative spaces, known as Arena events, and also established and still nurtures a “Community of Practice” and its own Knowledge Commons.
Multicenter study to compare the diagnostic performance of CLIA vs. FEIA transglutaminase IgA assays for the diagnosis of celiac disease
Authors: Castelijn Daan A.R. , Mulder A.H. Leontine , van der Pol Pieter , Hollander Jolien C. , Kuiper Tietie , Bijnens Caroline , Damoiseaux Jan , Bontkes Hetty J.
Published: March 2023

Objectives

Celiac disease (CD) is an immune-mediated enteropathy driven by gluten intake. Presence of tTG-IgA antibodies is important for the diagnosis. However, different tTG-IgA assays are used and test performance may vary. Therefore, a retrospective multicenter study was performed to compare the diagnostic performance of three assays.

Methods

The fluorescence enzyme-linked immunoassay (FEIA) EliA Celikey IgA (Phadia), the chemiluminescence immunoassays (CLIA) h-tTG IgA QUANTA Flash® (Inova Diagnostics) and the anti-tTG ChLIA IgA (Euroimmun) were compared. Diagnostic samples from CD cases (95 adults; 65 children) and controls (479 adults; 253 children) were included. Samples were blinded and reanalyzed on all platforms.

Results

A high quantitative correlation between platforms was found (p<0.0001). Both CLIA were more sensitive (adults 100%; children 100%) compared to the FEIA (adults 88.4%; children 96.6%). Specificity of all assays was high (≥97.6%) with the FEIA having the highest specificity. A cut-off based on receiver operator characteristic analysis (6.5 U/mL) improved the sensitivity of the FEIA (adults 95.8%; children 100%) without affecting specificity. Cut-off values for the CLIA assays did not need further optimization. With the FEIA, 71% of pediatric cases had a tTG-IgA level ≥10× upper limit of normal compared to 91 and 92% with QUANTA Flash and ChLIA, respectively.

Conclusions

All platforms have high diagnostic accuracy. The CLIA assays are more sensitive compared to the FEIA assay. A lower cut-off for the FEIA improves diagnostic performance, particularly in adult cases that, as demonstrated in this study, present with lower tTG-IgA levels compared to pediatric cases.
A novel electrochemical micro-titration method for quantitative evaluation of the DPPH free radical scavenging capacity of caffeic acid
Authors: Li Xiaofen , Yang Zhi , Gao Yuntao , Xiong Huabin
Published: March 2023

In this report, the stoichiometric ratio (R) for the interaction of diphenylpicrylhydrazyl (DPPH) radicals with the antioxidant was employed as an evaluation index for the DPPH radical scavenging activity of antioxidants. This evaluation index was related only to the stoichiometric relationship of DPPH radicals with the antioxidant and had no relationship with the initial DPPH amount and the sample volume, which could offer a solution to the problem of poor comparability of EC50 values under different conditions. A novel electrochemical micro-titration method was proposed for the determination of the stoichiometric ratio (R) for the interaction of DPPH radicals with the antioxidant. This electrochemical micro-titration model was verified using caffeic acid as the DPPH radical scavenger, with the stoichiometric ratio (R) of DPPH radicals to caffeic acid determined to be in the range of 2.003–2.046. The calculated EC50 values were 0.513, 1.011, and 1.981 × 10–5 mol/L for 2.10, 4.05, and 8.02 × 10–7 moL of added DPPH radicals, respectively. The proposed method showed no differences from the conventional method, but had better precision and reliability, and used a smaller amount of sample.
On the stochastic integral representation of Brownian functionals
Authors: Namgalauri Ekaterine , Purtukhia Omar
Published: March 2023

In this paper, we study the question of representing one class of Brownian functionals as a stochastic Itô integral with an explicit form of the integrand. The considered class of functionals also includes functionals that are not smooth in the sense of Malliavin, to which both the well-known Clark–Ocone formula (1984) and its generalization, the Glonti–Purtukhia formula (2017), are inapplicable.
Size-Effects on the VHCF Response of Flat Metallic Specimens for Automotive Applications: Analysis of Fatigue Data with a Method Based on the Stress Gradient
Authors: Tridello Andrea , Boursier Niutta Carlo , Berto Filippo , Paolino Davide Salvatore
Published: March 2023

The design against fatigue failures at very high number of cycles (VHCF) is fundamental to guarantee the integrity of components used in structural applications (aerospace, energy production, automotive). Experimental tests to assess the VHCF response of materials are generally carried out on small specimens with sizes that are significantly different from those of the components to be designed. Size-effect, which is widely known to affect the VHCF response, must therefore be properly modeled and accounted when components are designed to ensure their structural integrity. Size-effects in VHCF have been generally investigated by testing specimens with circular cross-sections and modeled by considering the probabilistic increment of the defect size with the loaded volume. In the present paper, ultrasonic fatigue tests have been carried out on hourglass flat specimens and larger dog-bone flat specimens to investigate size-effects. One aluminum alloy and four steels used for automotive applications have been tested. The experimental results have been analyzed with an innovative statistical model based on the weakest-link principle and on the stress gradient within the specimens, which does not require the size of the defect at the origin of the fatigue failure, generally not available if the specimen fails from the surface. Size-effects were found to significantly influence the VHCF response of the investigated materials, further confirming that it is strongly material dependent, even for flat specimens. A general rule for size-effect in VHCF of flat specimens was not found, proving that it must be properly experimentally verified and safely accounted when designing large components against VHCF failure.
Sexual risk behavior among individuals seeking outpatient mental health services: Associations with childhood emotional neglect and identity dysfunction
Authors: Spidel Alicia , Kealy David
Published: March 2023

This study was developed to examine sexual risk behavior among patients seeking community-based mental health services, including associations with psychological distress, identity dysfunction, and childhood emotional neglect. A mediation model was examined regarding identity dysfunction mediating the link between emotional neglect and sexual risk behavior. A total of 245 outpatients completed questionnaires regarding perceived risky sexual behavior, psychological distress, identity dysfunction, and emotional neglect. Sexual risk behavior was found to be a prevalent issue among individuals seeking outpatient mental health services, with 13% reporting engagement in unsafe sexual practices at least some of the time. Mediation analysis revealed that childhood emotional neglect was indirectly linked with sexual risk behavior through the mediating effect of identity dysfunction. Thus, findings suggest a pathway to sexual risk behaviors through perceived childhood emotional neglect and identity dysfunction. Clinical attention to identity-related vulnerability among this population may be warranted in aiming to mitigate risk-taking associated with sexual practices.
PSEUDO-TAHILLARIN ANTİ-BESİNSEL BİLEŞİKLERİ VE AZALTMA YÖNTEMLERİ
Authors: ARSLAN Ayşenur , YALÇIN Erkan
Published: March 2023

Pseudo-tahıllar, karabuğday, kinoa ve amaranttan meydana gelmektedir. Glutensiz olmaları sebebiyle, çölyak hastalığı veya glutene hassasiyeti bulunan bireyler için çok önemli gıda kaynaklarıdır. Pseudo-tahılların tüketiminin, anti-besinsel bileşiklerinin gıda güvenliğini riske atması sebebiyle sınırlandığı bildirilmiştir. Pseudo-tahıllar, saponin, tanen, nitrat, okzalat, lektin, proteaz inhibitörleri ve fitik asit gibi bazı anti-besinsel bileşikleri içerirler. Anti-besinsel bileşiklerin, gıdanın sindirilirliğini ve besin ögelerinin emilimini engelleyerek, besinsel değerini azalttığı belirtilmiştir. Bu bileşiklerin sebep olduğu zararlı metabolik olayları azaltmak/ortadan kaldırmak için pseudo-tahılların tüketiminden önce uygun bir teknikle işlenmesi gerekir. Uygulanacak yöntem seçilirken anti-besinsel bileşiklerin kimyasal yapısı, tohum içerisindeki dağılımı, biyolojik etkileri, ısıya duyarlılıkları ve suda çözünürlükleri ile işlemin maliyetinin bilinmesi tavsiye edilmektedir. Bu yöntemler kavuz ayırma, mekanik aşındırma, su ile yıkama, ıslatma, kaynatma, kavurma, ekstrüzyon, çimlendirme, fermantasyon, yüksek hidrostatik basınç ve genetik yöntemlerdir.
SUSTAINABLE BANKING, FINANCIAL STRENGTH AND THE BANK LENDING CHANNEL OF MONETARY POLICY
Authors: Cantero-Saiz María , Torre-Olmo Begoña , Sanfilippo-Azofra Sergio
Published: March 2023

The aim of this article is to analyse how sustainable banking affects the transmission of monetary policy through the bank lending channel. We also quantify how these effects are determined by the financial strength of each bank. These objectives, which have not been studied previously, represent an important contribution because real sustainable concerns in banking did not emerged until recently, mainly with the adoption of the Sustainable Development Goals that should be reached by 2030. Since then, some studies have focused on the effects of sustainability on aspects such as bank profitability, risk or efficiency, but none has considered the effects on the bank lending channel of monetary policy. In fact, central banks have incorporated sustainability criteria into their agenda and are analyzing how to include these criteria in the monetary policy framework, so we contribute even more by shedding some light on these aspects and how they depend on the financial strength of the banking sector. We used quarterly data from 79 listed banks from the OECD between 2016 and 2019 (947 observations) and we found that the bank lending channel is operative either for banks with very low sustainability ratings or a weak financial position. When sustainability ratings increase and financial strength becomes moderate, the bank lending channel is ineffective and monetary shocks do not affect lending. For banks with certain sustainable compromises and a strong financial position, the impact of monetary shocks on lending is the opposite of the one that the bank lending channel proposes, and this impact is more intense as sustainability ratings increase. Finally, our results also show that increases in central bank assets boost lending only for banks with low or moderate sustainability ratings, regardless of their financial strength. Overall, these results suggest that more sustainable banks are less dependent on monetary policy decisions.