bluuebunny/crossref_metadata_2025 huggingface dataset:
AMPUTATION OF THE INDEX FINGER IN MELANOMA AND INDEXING OF THE MEDIUS: CASE REPORT
Authors:   Department of Plastic, Reconstructive, Aesthetic and Burn Surgery, UHC Mohammed VI, Marrakech, Morocco., Elgueouatri M. , Atiqi O. ,   Department of Plastic, Reconstructive, Aesthetic and Burn Surgery, UHC Mohammed VI, Marrakech, Morocco., Amrani M.D. ,   Department of Plastic, Reconstructive, Aesthetic and Burn Surgery, UHC Mohammed VI, Marrakech, Morocco., Benchamkha Y. ,   Department of Plastic, Reconstructive, Aesthetic and Burn Surgery, UHC Mohammed VI, Marrakech, Morocco.
Published: June 2022

We report the case of a 50-year-old patient, referred by the dermatology department of the Mohammed VI University Hospital of Marrakech for amputation of the index finger due to a melanoma diagnosed by biopsy. The amputation was performed using the Chase technique. The aesthetic and functional result was very satisfactory after the operation.
BENEFICIAL EFFECT OF CARDIAC REHABILITATION ON MOROCCAN PATIENTS AFTER VALVULAR SURGERY
Authors: Fassi-Fehri Zineb , Chraibi Hamza , Chrifi Fatima-Zahrae , El. Malki Berrada Nabil , Mouine Najat , Benyass Aatif
Published: June 2022

Introduction : Valvular disease is common in Morocco, frequently followed by a heart surgery. Cardiac rehabilitation can improve functional and cardio-respiratory capacities after valve surgery, joining training sessions, therapeutic education, and optimization. The present study features the results in Moroccan patients. The objective of the study is to confirm the hypothesis that cardiac rehabilitation is beneficial after valvular surgery. Methods : Its a retrospectivestudy made between November 2017 and January 2020 including40 patients after valvular surgery incardiac rehabilitation unit of cardiology centerof Mohamed V Military Hospital.All of them had aclinical examination, laboratory test, ECG, echocardiography, 6 minuteswalk test and test with VO2 max. Results :The average age was 45.6 Â± 12.3 years with a male predominance.Regarding cardiovascular risk factors, we found sedentary lifestyle, smoking, dyslipidemia, hypertension, and diabetes.Echocardiography showed a preservedejection fraction (EF = 55.69 % Â± 11.02 %).After 20 cardiac rehabilitation sessions, all patients improved their effort capacities.They increased the distance covered in6-minutes walk test from 500 to 545.7m, andstress test parameters from 82.5 Â± 32.93 W to 100.2 Â± 36.8 W for the load, from 32 Â± 8.24 to 21.7 Â± 9.8 ml/kg/min for the VO2 max and the training heart rate decreased from 111.5 bpm to 107.6 bpm (beats per minute). Conclusion :This study demonstrated that cardiac rehabilitation program is clearly beneficial in patients after valvular surgery by theimprovement of their functional and cardio-respiratory capacities.
A COMPREHENSIVE WATER QUALITY REVIEW OF RIVER YAMUNA WITH SPECIAL REFERENCE TO WATER QUALITY INDEX IN THE HIMALAYAN REGION OF INDIA
Authors:   Associate Professor, Department of Geography, SDM Govt. P.G College, (Sridev Suman University) Dehradun, Uttarakhand, India., Baloori S.S. , Upreti Pallavi ,   Assistant Professor, Department of Geography, SDM Govt. P.G College, (Sridev Suman University) Dehradun, Uttarakhand, India., Kukreti Jyotsna ,   Lecturer, Sri Guru Ram Rai Public School, Patel Nagar, Dehradun, Uttarakhand.India.
Published: June 2022

India with 4% of fresh water resources is facing a dual challenge of water scarcity and pollution. Several rivers in India originate from Himalayan systems and forms the basis of Indias Economy. River contamination and diminishing water quality is reducing populations accessibility to clean and safe drinking Water. As one of the significant perennial tributaries of The Ganga Water systems, River Yamuna passes through the heartlands of thegreat North India Plains sustaining cities, feeding millions. Since Yamuna passes through major urban settlement it is heavily polluted with untreated industrial waste, sewage, domestic waste making its way into the river. The study presents a comprehensive reviewof the water quality assessmentsof theriver Yamuna with special reference to Water Quality Index based on severalhydrological parameters. Based on the levels of contamination the whole stretch of Yamuna from its source (at Uttarakhand) till its confluence with Ganga (at Allahabad) has been divided into 5 segments. While all the lower stretches depict high to very high pollution levels, the upper segment of the river in the Himalayas show good water quality. Water quality parameters of river Yamuna depict that BOD, DO and COD levels are not in range of permissible limits in Delhi segment but it falls under permissible limits range in Himalayan segment. Other than these parameters, ammonia, TKN and other organic and inorganic matters fall under the desired standards in Himalayan region of Yamuna.
A PROSPECTIVE DESCRIPTIVE STUDY OF TRAUMA REGISTRY IN NETAJI SUBHASH CHANDRA BOSE MEDICAL COLLEGE, JABALPUR
Authors: Sirsikar Ashish , Raza S.M.G. , Vidyarthi Ashok
Published: June 2022

Background: Trauma registries are databases of information regarding patients who have been came and treated in hospital for injuries caused by trauma. Aim: The objectives of this study to collect data related to trauma registry presenting to our center, as well as to analyze the demographic characteristics and other relevant data of patients admitted in our center. Methods: A Prospective descriptive demographic study was conducted in Tertiary care center Netaji Subhash Chandra Bose Medical College and Hospital Jabalpur from 1st January 2020 to 30th June 2021. In our study included patients who present at our center with history of recent Orthopaedic trauma and sustained fracture within 48 hours. In our study excluded isolated head injuries. The data collected was analyzed. Results: Out of 10241 patients, 7271(71%) were male and 2970(29%) were female with 2253(22%) in the 21-30 age group. Road traffic accident was the major cause of trauma (56%)followed by fall and slips (22%) and assaults(18%).The majority of these patients were brought by their family members (68%).Close to half of patients had upper extremity injury (48%) followed by lower extremity injury (45%) followed by Spinal injury (4%) and Pelvis injury(3%). Conclusion: Trauma registry is complex database of demographic, injuries and outcomes of trauma patients. This study can help to decreasing the burden of trauma and improve health system.
DETERMINANT OF PEPPER PLANTATION PRODUCTIVITY TOWARDS THE LOCAL ORIGINAL INCOME AND ITS IMPLICATIONS ON FARMERS EXCHANGE RATES IN BANGKABELITUNG ISLANDS INDONESIA
Authors:   Lecturers University of West Sumatera, Indonesia., Imar Pratama Marshal , a Misharni ,   Lecturers University of West Sumatra, Indonesia., b Yolanda ,   LecturersUniversity of Borobudur, Jakarta, Indonesia.
Published: June 2022

The decline in pepper productivity in Bangka Belitung Islands Province is due to the fact that most pepper plantations are peoples plantations that still use traditional cultivation techniques without adequate technological innovations. The purpose of this study is to find and analyze the influence of planting area, domestic investment, banking financing and pepper prices on the productivity of pepper plantations and their implications on the native income of the region and the exchange rate of farmers in the Bangka Belitung Islands Province.The data analysis used in this study is a linear regression with the Ordinary Least Square approach. The results showed that (1) planting area, domestic investment, banking financing and pepper prices both simultaneously and partially have a significant and positive effect on the productivity of pepper plantations, (2) the productivity of pepper plantations has a significant and positive effect on Local Original Income, (3) Local Original Income has a significant and positive effect on farmers exchange rates, (4) subsequent research findings, the influence of Local Original Income resulting in Bangka Belitung Islands Province is significantly able to have an impact on increasingwelfare of pepper farmers.
EFFECT OF DIFFERENT SALIVA DECONTAMINATION PROCEDURES ON THE SHEAR BOND STRENGTH OF A UNIVERSAL EIGHTH GENERATION ADHESIVE SYSTEM TO DENTIN AFTER POLYMERIZATION - AN IN VITRO STUDY
Authors:   Post Graduate Student, Department of Pediatric and Preventive Dentistry, Divya Jyoti College of Dental Sciences and Research., Leleesh Mayanglambam , Somani Rani ,   Professor and Head, Department of Pediatric and Preventive Dentistry, Divya Jyoti College of Dental Sciences and Research., Basu Payel ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, Divya Jyoti College of Dental Sciences and Research., Renuka Oinam ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, Divya Jyoti College of Dental Sciences and Research., Thanglienzo Grace ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, Divya Jyoti College of Dental Sciences and Research.
Published: June 2022

Aim: To evaluate and compare the effect of saliva decontamination procedure on the shear bond strength of a Universal eighth generation adhesive system to dentin after polymerization. Materials & Method: Forty extracted non-carious premolars were mounted on a acrylic block and their occlusal surfaces were grounded flat to exposed the middle depth dentin. The teeth were then randomly divided into five Groups: Group A(control), Group B(Bonding, Saliva, Air-dried), Group C(Bonding, Saliva, Air-dried, Rinse), Group D(Bonding, Saliva, Air-dried, Re-bonding) & Group E (Bonding, Saliva, Air-dried, Rinse, Re-bonding). A teflon tube of 2x3 mm dimension was used to pack composite on the treated dentin surface and light cured for 40s. Shear Bond strength was then measured using instron testing machine at a crosshead speed of 1mm/min. Data were statistically analysed using ONE WAY-ANOVA and TUKEYS test. Result: It was observed that, the highest mean shear bond strength was found in Group D(Bonding, Saliva, Air-dried, Re-bonding) & Group E(Bonding, Saliva, Air-dried, Rinse, Re-bonding) with a mean value of 23.87 each. The least mean value was seen in Group C(Bonding, Saliva, Air-dried, Rinse), 13.25. When an intergroup comparision was made, statistically significant difference was seen between the various groups except Group A(control)-Group D(Bonding, Saliva, Air-dried, Re-bonding)-Group E(Bonding, Saliva, Air-dried, Rinse, Re-bonding) and Group B(Bonding, Saliva, Air-dried)-Group C(Bonding, Saliva, Air-dried, Rinse). Conclusion: Salivary contamination significantly decreases the bond strength of the adhesive to dentin after polymerization. Rinsing and Air-drying of the cured contaminated dentin surface was not sufficient to restore the shear bond strength. However reapplication of adhesive system after rinsing and air-drying of the cured contaminated dentin surface fully restored the bond strength.
CAESAREAN SECTION RATES AT THE HOSPITAL MATERNITY: A CASE STUDY IN MOROCCO USING THE ROBSON CLASSIFICATION SYSTEM
Authors:   Ibn Tofail University, Kenitra, Maroc., Hassan Chrifi ,   National School of Public Health (ENSP), Rabat, Maroc., Bouchra Assarag ,   National School of Public Health (ENSP), Rabat, Maroc., Ikram Boudallaa ,   Ibn Tofail University, Kenitra, Maroc.,   National School of Public Health (ENSP), Rabat, Maroc., Abderrahmane Amine Bititi ,   Cheikh Khalifa Hospital, Casablanca, Maroc., Abdelmajid Soulaymani ,   Ibn Tofail University, Kenitra, Maroc.
Published: June 2022

Caesarean section rates continue to rise worldwide, although the reasons appear to be multiple and complex. To better understand and control the phenomenon, many countries have started to use the 10-group classification of Caesarean sections, also known as the Robson classification. This classification will monitor and compare standardized, reliable, consistent, and indication-oriented Cesarean section rates. As part of a quality improvement initiative aimed at rationalizing Caesarean section rates, our descriptive and retrospective study was conducted on a population of parturients who had given birth by Caesarean section at the maternity ward of the CheikhKhalifa Hospital in Casablanca. Our study was conducted over ten months. We listed all Caesarean deliveries and classified them into ten groups (Robsons classification) to identify the contribution of each group to the overall Caesarean rate and to explain potential discrepancies, the analysis of which enabled us to propose recommendations. Our study involved 890 cases, 541 of which required a Caesarean section, a rate of 61%, which is higher than the rate recommended by the WHO (15%) and the national rate (21%). This classification system allowed us to identify group 10 as the most contributing to the overall Caesarean section rate (43.4%). This group included singleton pregnancies with the cephalic presentation, gestational age < 37 weeks, and a scarred uterus. This groups relative size and Caesarean section rate were 68% and 63%, respectively. Caesarean section is a non-negligible surgical procedure with both maternal and neonatal risks. Robsons classification helps to ensure that women who need Caesarean sections receive them.
MAMDANI-TYPE FUZZY CONTROLLER TO DETERMINE BLOOD PRESSURE LEVELS BY REFLECTION PPG
Authors:   Department of Computer Science, Autonomous University of the State of Mexico., Garcia Limon J.C. , Mendoza Perez M.A. ,   Department of Computer Science, Autonomous University of the State of Mexico., Juarez Landin C. ,   Department of Computer Science, Autonomous University of the State of Mexico., Sanchez Soto J.M. ,   Department of Computer Science, Autonomous University of the State of Mexico.
Published: June 2022

This document presents the design of a fuzzy control system applying photoplethysmography techniques to generate input data and Mamdani-type fuzzy logic for its processing and generation of system output values, through which blood pressure levels can be indicated based on the parameters recommended by the medical area for an adult person. The integral design of the system includes the acquisition of the input signals, obtained through the reflection photoplethysmography technique, by means the optical coupling between IR light-emitting diodes and photo receptors, which allow the flow of current proportional to the amount of reflected light by blood, which is related to the flow level of the cardiac cavities, derived from the systolic and diastolic stages of the cardiac cycle. The fuzzy control was designed with two inputs and one output of 5 triangular membership functions each using the hardware description language (VHDL), the fuzzification, inference, aggregation and defuzzification stages were designed using the COSAA method. The response values â€‹â€‹obtained using the Test Bench tool of ISE Design suite were compared with theoretical values â€‹â€‹and with values â€‹â€‹obtained with the Fuzzy Logic Designer tool of Matlab, the results showed an excellent approximation.
FEMALE GENITAL MUTILATION : THE UNTOLD STORY OF INDIA
Authors:   Department of Law, Assam University, Silchar, India., Rahul Singha K.
Published: June 2022

Female Genital Mutilation is a human rights violation that is practised in India. The Bohra community uses it extensively. FGM/C is thought to be practised for non-medical or cultural reasonsas well as to protect a women virginity before marriage by limiting her enjoyment of intercourse and to deter her from becoming disloyal to her husband after marriage. Hence, FGM/C not only violates the right to life and dignitybut it also clearly violates the right to equality based on gender. The intent, purpose and impact of male and female circumcision are all distinct resulting in gender discrimination.Thus, it is pertinent to note that such cruelty is prevalent in India with female children aged 1 to 15 years being victims of Female Genital Mutilation.
NEEYA NAANA - SOME RECENT DIRECT METHODS VERSUS SOME CHALLENGING PROBLEMSIN TRANSPORTATION PROBLEMS
Authors:   Associate Professor,Department of Mathematics, St. Johns College, Palayamkottai-627002, Manonmaniam Sundaranar University, Tirunelveli-627012, Tamil Nadu, India., Murugesan R.
Published: June 2022

In this research article, the twelve direct methods developed by different researchers to solve Transportation Problems (TPs)during the period 2012 - 2021 is considered as one group and twenty onechallenging TPs (balanced and unbalanced) identified and acknowledged from various published articles and textbooks is considered as another group. We assessand discuss the performance of each ofthe direct methods on the challenging TPs. and brings out the fact and fantasy. Our aim is to encourage and motivate the future author(s) to develop better and best methods to deliver optimal solutions directly to all the TPs.Most of the direct methods introduced are easy to understand, easy to apply, consumes less time, innovative and different from the existing methods. We appreciate the contributions of the authors. However, in reality, testingoutcomes by their methods on the challenging TPs authenticate that no one method has produced optimal solution directly to all the identified TPs. Consequently, no author(s) can claim that their introduced method is direct. Each method introduced is just a method to generate an initial basic feasible solution (IBFS) and not a direct method. The added advantage of this article is toassess the performance of any innovative method presented on TP in the future, the acknowledgedchallenging problems may be trialed for testing and validating the proposed novel method. Really, the identified challenging problems create a challenge to the direct methods.
CLINICAL EVALUATION OF EFFICACY AND SAFETY OF TRANSVERSUS ABDOMINIS PLANE BLOCK INJ. LEVOBUPIVACAINE AND INJ. ROPIVACAINE FOR POST OPERATIVE ANALGESIA FOLLOWING LOWER SEGMENT CESAREAN SECTION : A PROSPECTIVE, RANDOMIZED, DOUBLE BLIND STUDY
Authors: M. Parmar Prashant , S. Mehta Vandana , V. Modi Hardul , M. Parmar Ravi
Published: June 2022

Backgrounds and Aims :Levobupivacaine is a pure S-enantiomer of bupivacaine with similar anesthetic profile and with reduced toxic potential than racemic bupivacaine.This study aims to compare efficacy and safety of Transverse Abdominal Plane block inj. Levobupivacaine Vs. Inj. Ropivacaine for post operative analgesia following lower segment cesarean section. Methods and Material:A prospective, randomized, controlled, double blind clinical study. 60 patients divided in 2 groups by computer generated randomization.60 healthy women undergoing cesarean delivery under spinal anesthesia were randomized into two groups (Group I, Group II). Group I received TAP block with 15 ml of 0.25% ropivacaine while Group II received TAP block with 15 ml of 0.25% levobupivacaine on each side. Postoperatively, time for first request for rescue analgesia and number of women requesting analgesia in 6 h,8 h, 10 h, 12 h and 24 h were noted. Pain score was measured with the Visual Analogue Scale (VAS) at rest and on first 24 h. Patient comfort and satisfaction with analgesia was evaluated at the end of 24 h. Statistical analysis used:The data were analyzed with Students tâ€‘test. Results:The duration of analgesia was significantly prolonged in Group I than group II. The VAS score in patients who received Inj. Ropivacaine was significantly lower than who received inj. Levobupivacaine. Patient and surgeon satisfaction score were significantly higher in Ropicavaine than levobupivacaine. Conclusions:0.25% Ropivacaine provided longer duration of analgesia compared to 0.25% Levobupivacaine in TAP Block for postoperative analgesia after lower segment cesarean section.
ROLE OF WOMEN ETREPRENEURSHIP IN INDIAN ECONOMY
Authors:   Assistant Professor, Department of Commerce and Management Prerna College of Commerce, Nagpur., Katakwar (Hatewar) Shivani
Published: June 2022

Women entrepreneurship was a neglected domain during the past, but with the spread of education and awareness among the ladies the image has been changed and therefore the women have emerged as todays most memorable and inspirational entrepreneurs. Its said that family may be a chariot with wheels which are driven by both the male and feminine members of the family. If one among the wheels is lagging behind, the chariot i.e. the family wont be ready to grow and develop. Within the same way once we discuss a nation the ladies entrepreneurship plays a dominant role within the economic development and makes significant contributions to the economic process of the country. The event of the country would be very slow if the ladies entrepreneurship is ignored and stopped to hitch the most streams of productive activities. This paper unfolds the importance of women entrepreneurship and also focuses the role of women entrepreneurs within the Indian economy and also their contributions to the economic development. Various broader objectives like growth with equity are often achieved by enabling the event of women entrepreneurship. Theres necessity of molding and shaping the ladies entrepreneurship with the entrepreneurial traits and skills. This may enable the ladies to adapt with the changing trends in both the domestic and global markets and built up competencies enough to sustain and strive for excellence.
ENERGY AUDIT PROCEDURES AND ENERGY SAVINGS OPPORTUNITIES IN EDUCATIONAL INSTITUTIONS AND INDUSTRIAL SECTORS
Authors:   Nature Science Foundation, Coimbatore - 641 004, Tamil Nadu, India., Mythili Gnanamangai B. , Rajalakshmi S. ,   Nature Science Foundation, Coimbatore - 641 004, Tamil Nadu, India., Kumar Srivastava Ashutosh ,   Central Zone, Nature Science Foundation, Gorakhpur - 273001, Uttar Pradesh, India., Sudhakaran R. ,   North Zone, Nature Science Foundation, Faridabad - 101 213, Haryana, India., Murugananth G. ,   DepartmentofElectrial and Electronics Engineering, Ahalia School of Engineering and Technology, Palakkad - 678 557, Kerala., Thirumoorthi P. ,   Department of Electrial and Electronics Engineering, Kumaraguru College of Technology, Coimbatore - 641 049, Tamil Nadu.
Published: June 2022

An energy audit is a survey in which the study of energy flows for the purpose of conservation is examined at an Organization. It refers to a system analysis that seeks to reduce the amount of energy used in an Organization without impacting the output. The audit includes suggestions of alternative means and remedial methods for achieving energy savings to a greater extent. Conventionally, electrical energy is generated by means of fossil fuels, hydraulic and wind. Exploitation of fossil fuels and their depletion rate, insist the need for alternate energy source and conservation of electric energy. Primary objective of an energy auditing and management of energy consumption is to offer goods or services at the lowest possible cost and with the least amount of environmental impact. The need for an energy audit is to identify the savings potential and cost reducing methods, understand the ways in which fuel is used, where, the waste occurs and find the scope for improvement.Preparation and completion of a questionnaire, physical examination of the campus, observation and examination of documentation, key person interviews, data analysis, measurements and suggestions are all part of the audit processes.In general, energy audit is the translation of conservation ideas into realities, by lending technically feasible solutions with economic and other organizational considerations within a specified time frame.
Role of BLACAT1 in IL-1β-Induced Human Articular Chondrocyte
Apoptosis and Extracellular Matrix Degradation via the miR-149-5p/
HMGCR Axis
Authors: Li Zhiquan , Wang Yingchun , Wu Yaoping , Liu Yanwu , Zhao Yinan , Chen Xiaochao , Li Mo , Zhao Rui
Published: June 2022

Background:

Osteoarthritis (OA) is an inflammatory joint disorder with high incidence
rates. Long non-coding RNAs (LncRNAs) influence OA development.

Objectives:

In this research, we attempt to figure out the functions of lncRNA BLACAT1 in human
articular chondrocyte (HAC) apoptosis and extracellular matrix (ECM) degradation in OA.

Methods:

Interleukin (IL)-1β was employed to induce HAC damage. Cell viability and apoptosis
were detected, with expression patterns of lncRNA BLACAT1, miR-149-5p, and HMGCR, and
levels of Caspase-3, Caspase-9, BAX, Bcl-2, COL2A1, and SOX9 determined. Then, lncRNA
BLACAT1 was silenced in IL-1β-treated HACs to analyze its role in HAC damage. The target
relations of lncRNA BLACAT1 and miR-149-5p and miR-149-5p and HMGCR were verified. In
addition, combined experiments were performed as a miR-149-5p inhibitor or HMGCR
overexpression was injected into cells with lncRNA BLACAT1 silencing.

Results:

In IL-1β-treated HACs, lncRNA BLACAT1 and HMGCR were overexpressed while miR-
149-5p was poorly expressed, along with reduced cell viability, enhanced apoptosis, elevated
Caspase-3 and Caspase-9 activities, increased BAX level, decreased Bcl-2 level, and declined levels
of COL2A1 and SOX9, which were reversed by lncRNA BLACAT1 silencing. LncRNA
BLACAT1 targeted miR-149-5p, and miR-149-5p targeted HMGCR. miR-149-5p knockout or
HMGCR overexpression annulled the inhibitory role of lncRNA BLACAT1 silencing in HAC
apoptosis and ECM degradation.

Conclusion:

LncRNA BLACAT1 was overexpressed in IL-1β-treated HACs, and the lncRNA
BLACAT1/miR-149-5p/HMGCR ceRNA network promoted HAC apoptosis and ECM degradation.
Multivariate Models of Blood Glucose Prediction in Type1 Diabetes:
A Survey of the State-of-the-art
Authors: Kumar Shailender , Arora Sunny , Kumar Pardeep
Published: June 2022

Diabetes mellitus is a long term chronicle disorder with a high prevalence rate worldwide. Con-tinuous blood glucose and lifestyle monitoring enabled the control of blood glucose dynamics through machine learning applications using data created by various popular sensors. This survey aims to assess various classical time series, neural networks and state-of-the-art regression models based on a wide variety of machine learning techniques to predict blood glucose and hy-per/hypoglycemia in Type 1 diabetic patients. The analysis covers blood glucose prediction mod-eling, regression, hyper/hypoglycemia alerts, diabetes diagnosis, monitoring, and management. However, the primary focus is on evaluating models for the prediction of Type 1 diabetes. A wide variety of machine learning algorithms have been explored to implement precision medicine by clinicians and provide patients with an early warning system. The automated pancreas may benefit from predictions and alerts of hyper and hypoglycemia.
Molecular Docking, Dynamics Simulation, and Physicochemical Analysis
of Some Phytochemicals as Antiplatelet Agents
Authors: Pourhanafi Shabnam , Gürsoy Vildan Adar
Published: June 2022

Background:

Antiplatelet drugs are key tools for the prevention and elimination of cardiovascular disease. However, currently available agents are associated with a variety of adverse effects, and new therapeutically effective drugs with fewer or no side effects are urgently needed for effective medication.

Objective:

The present in silico research aimed to determine the inhibitory potential of 50 phytochemicals on platelet function using computational methods.

Methods:

The compounds first were subjected to molecular docking analysis with five chosen antiplatelet targets and the best compound with the lowest energy against each target was selected and analyzed in detail. These complexes were then considered for molecular dynamics simulation and binding free energy analysis. SwissADME and ADMETlab servers were also used to evaluate their drug-likeness and ADMET properties.

Results:

Ligands that exhibited the lowest energy with the corresponding target were: graveolinine
against COX-1, sanguinarine against P2Y12 and PDE-3, rutin against GP-VI, and bisdemethoxycurcumin
against PAR-1. Simulation of these complexes affirmed the binding stability between the ligands and the
proteins. Root mean square deviation and root mean square fluctuation showed that in the case of PAR-1-
bisdemethoxycurcumin, some fluctuations were observed during the simulation process. Calculation of
the binding free energy indicated that in all systems, the van der Waals energy made a significant contribution
to the binding and stability of the system.

Conclusion:

The result of this study could provide useful insights into the development of new lead antiplatelet agents.
A Mini-Review on the Synthesis of Substituted Isatins: From Early Approaches
to Recent Advances with a Specific Focus on Sulfamoyl and
Amino Derivatives
Authors: Temizer Asu Büşra , Koulani Taha , Eter Özge Soylu , Karali Nilgun
Published: June 2022

As a member of heterocyclic compounds, indole possesses a diverse set of biological activities.
Studies on the structure-activity relationship of 2-indolinones have shown that they are important
bioactive compounds in the field of pharmaceutical chemistry. Isatin and structures bearing isatin scaffold
are derivatives of indole, which have shown to be of biological and pharmacological significance.
This review focuses on different ways of obtaining compounds containing isatin structure, considering
both earlier and recent methods of synthesis. The syntheses given herein were grouped into three categories,
syntheses using anilines as their starting substance, synthetic methods based on the oxidation of
indoles, and finally, due to the extensive research going on 5-substituted isatins and their possible
pharmacological efficacy, pathways for synthesizing 5-amino and 5-sulfamoylisatins were gathered to
underline the importance of 2-indolinone and isatin derivatives as prospective therapeutic compounds
in current and future drug discovery studies.
Screening of Natural Antivirals Against the COVID-19 Pandemic- A
Compilation of Updates
Authors: Goswami Tridib Kumar , De Baishakhi , Raghavan Vijaya G.S.
Published: June 2022

Background:

Coronavirus disease 2019 (COVID-19), named by WHO, is a public health disaster of the third millennium. This acute respiratory distress syndrome (ARDS) has severe complications like pneumonitis, respiratory failure, shock, multi-organ failure, and finally, death. Despite repurposing of broad-spectrum antivirals, vaccinations, use of mask sanitizers, social distancing, intermittent lockdowns and quarantine, long-term protection or eradication of coronavirus is yet to be achieved.

Objectives:

This comprehensive review makes a compilation of updates on the screening and evaluation of natural antivirals that are found to show anti-COVID potency.

Methods:

Literature mining was done in phytotherapy and food research journals, Pubmed, Scopus, Elsevier for collection of latest research updates focusing on screening and evaluation of anti-COVID natural antivirals.

Results:

In silico molecular docking studies have screened several phytochemicals and food bioactive principles with significant potencies against the corona virus. The anti-COVID potency of the phytochemicals is mostly by restricting the action of enzymes like the main protease (Mpro), 3-chymotrypsin like protease (3CLpro), spike proteins, papain-like protease (ACE2). Free radical scavenging, anti-inflammatory effect, DNA inhibition, prevention of viral attachment, and its penetration into the host body, inhibiting viral replication are other associated mechanisms of bioactive compounds present in plants, vegetables, fruits, spices and marine alga. Different formulations of Ayurveda, Siddha, Unani have shown their ameliorative effects. Many formulations of Traditional Chinese Medicine are under clinical trials.

Conclusions:

The immense potencies of bioactives that are omnipresent need to be properly utilized for immune-boosting and combat this deadly virus naturistically.
FAMILIA MORACEAE
Authors:   Instituto de Botánica, Universidad de Guadalajara, Carvajal Servando
Published: June 2022

Familia compuesta de 37 géneros y alrededor de 1100 especies, de distribución amplia en todo el mundo, sobre todo en las regiones intertropicales. En México las moráceas están representadas, de acuerdo con la opinión de diversos autores, por 10 géneros y 54 a 58 especies. En el área que nos ocupa se localizan seis géneros y 19 especies.
FAMILIA GROSSULARIACEAE
Authors:   Instituto de Ecología, A.C., Centro Regional del Bajío, Pérez-Calix Emmanuel
Published: June 2022

La situación taxonómica de Grossulariaceae ha sido muy debatida. La opinión de algunos botánicos es que debe de incluirse en el grupo de Saxifragaceae sensu lato; mientras otros sugieren que Grossulariaceae es un grupo independiente. Estudios de biología molecular realizados por Soltis y Soltis (op. cit.) sugieren que las Grossulariaceae son un grupo distinto de Saxifragaceae sensu stricto que se restringe a Ribes, género integrado por cerca de 200 especies distribuidas en las regiones templadas del Hemisferio Norte, en América se extienden por los Andes hasta Tierra del Fuego.
FAMILIA ROSACEAE
Authors:   Instituto de Ecología, A.C., Centro Regional del Bajío, Rzedowski Jerzy , Calderón de Rzedowski Graciela ,   Instituto de Ecología, A.C., Centro Regional del Bajío
Published: June 2022

Las Rosaceae contienen varios géneros de taxonomía muy complicada y controvertida, por lo que el cálculo del número, sobre todo de las especies, es bastante incierto. Se consideran unos 100 géneros con 2000 a 3000 especies representadas en todo el mundo, pero principalmente en regiones templadas y subtropicales del Hemisferio Norte.
FAMILIA VITACEAE
Authors:   Instituto de Ecología, A.C., Centro Regional del Bajío, Rzedowski Jerzy , Calderón de Rzedowski Graciela ,   Instituto de Ecología, A.C., Centro Regional del Bajío
Published: June 2022

Se calculan 11 géneros y unas 700 especies de amplia distribución principalmente en regiones tropicales, con excepción de Vitis que de preferencia es de lugares de clima templado. Algunos representantes de esta familia tienen interés alimenticio, medicinal u ornamental.
The Principle of Full Compensation for Harm and Its Reflection in the Legislation of the Russian Federation
Authors:   The Arbitration Court of Moscow, Grigorieva Irina M.
Published: June 2022

Relevance. One of the basic approaches for civil law is to allow the injured party to claim full compensation for the harm caused and the losses incurred. The widespread use of this approach is based on universal ideas about the reasonableness and fairness of full compensation to the injured party for the diminution of its property sphere at the expense of the offender or other harm-doer. Compensation of damages, directly related to the implementation of the principle of compensation for harm, plays a crucial role among all the means of protection of subjective civil rights specified in the list given in article 12 of the Civil Code of the Russian Federation. The purpose of the study is to develop theoretical provisions defining the specifics of implementation of the principle of full compensation for damages at the current stage of development of market economy and social relations in the Russian Federation. Objectives: to identify the problems associated with the implementation of the principle of full compensation for harm in the civil law of the Russian Federation; ; to determine the features of the balance of interests in the recovery of compensation and other cases of compensation for harm caused; to determine the directions of further development of legal regulation of the issues under consideration. Methodology. When writing the work, dialectical-materialistic method, systematic method, methods of analysis and synthesis, formal-legal method were used. The results of the research are of a theoretical and applied nature and are aimed at improving the quality of legal regulation of civil legal relations. The conclusions made in the article are of debatable character, are aimed at continuing of researches in the framework of the stated theme, are aimed at development of the main principles that allow to solve in a unified way the problems connected with realization of the rights to full compensation of damage to the injured party at the expense of its causer. The article is a continuation of scientific studies of the author on issues related to the problems of civil liability.
Perineum massage as the implementation of non-pharmacological method in pregnant women trimester III in efforts to prevent tearing perineum at Toroh Public Health Center I
Authors: Yastirin Pintam Ayu , Sehmawati Sehmawati
Published: June 2022

Background : Incidence of maternal mortality in Central Java is 64.18% during the puerperium, 25.72% during pregnancy and 10.10% during childbirth. Of the 35 districts / cities in Central Java, Grobogan Regency was recorded as one of the districts with the most MMR (AKI) in 2019, amounting to 36 cases. Emergencies can occur during the puerperium which are often caused by bleeding, infection and pre-eclampsia. cases of bleeding during the puerperium are caused by major risk factors such as uterine atony (70%), lacerations of the birth canal (20%), retained placenta (10 - 20%) and coagulopathy (1%).hemorrhage Post partum due to perineal tearing can be minimized by improving the quality of service both promotive, preventive, curative and rehabilitative. One method of preventing perineal tearing can be done since pregnancy by performing perineal massage.

Objectives : The purpose of this study was to determine the effectiveness of perineal massage in third trimester pregnant women as a non-pharmacological method in preventing perineal tears at Toroh I Health Center.

Methods : The study used a pre-experimental design with amodel static group comparison, with a sample selected using a purposive sampling technique of 48 pregnant women. The research data used is in the form of primary data and secondary data. The research was analyzed using univariate and bivariate analysis using the test Fisher Exact Probability.

Results : The results of the research were univariate analysis of 50% of respondents doing perineal massage, 58% of respondents did not experience perineal rupture, while the bivariate analysis of perineal massage variables and perineal rupture variables showed p-value <0.05 with OR: 18.142 at the 95% confidence level.
Conclusions : There is a significant effect between perineal massage on the incidence of perineal rupture at Toroh Public Health Center I.
Factors influence sexual behavior in adolescent: a literature riview
Authors: Ningrum Puspita , Kusbaryanto Kusbaryanto
Published: June 2022

Background: Adolescence is a period where there is a change in transition between childhood and adulthood. Sexual behavior is one form of adolescents committed during the transition. Adolescent sexual behavior is a form of sexual drive or a desire that is done by both men and women. Sexual behavior by an average adolescents is a form of desire and curiosity from adolescents.

Aim: This study aims to describe what factors influence adolescent sexual behavior

Method: This research is a literature review research. The source obtained was taken from several databases such as Google Scholar, found 7,130 journals, 311,653 ProQuest, 2,318,728 PubMed. Based on the overall database data, only 8 journals met the inclusion criteria

Results: Factors of sexual behavior in adolescents in 8 journals discussing peers, male gender is more likely to engage in sexual behavior compared to women, authoritarian parenting style, parental consent about sexual access and perceptions of norms of people around adolescents themselves, families, school media and the community are significantly related to adolescent sexual experiences.

Conclusion: Based on the results of the 8 journals, the factors that greatly influence adolescent sexual behavior are the countryside and the media. These findings have many implications for health workers, especially community educators, to implement and develop interventions to prevent sexual risk behaviors.
The effect of black glutinous rice soaking on decreasing blood sugar levels in patients’ with type 2 diabetes mellitus in Batam
Authors: Muchtar Rizki Sari Utami , Agusthia Mira , Pramadhani Wulan
Published: June 2022

Background :Diabetes Mellitus, as abbreviated as DM, is a chronic disease characterized by an increase in glucose levels in the blood due to insulin damage, which can reduce the amount of glucose that enters into cells. Administration of black glutinous water soaking can reduce the need for chemical drugs, because with minimal resources it can increase the coverage and extend of nursing services without geographic boundaries.

Objectives :This research aimed to determine the effect of black glutinous water soaking on the decrease in blood sugar levels in patient with type 2 diabetes.

Methods :Research methods used quasi experimental. The sample consisted of 50 respondents with the inclusion criteria for type 2 DM patients who do not have gangrene complications and the data were analyzed using the Wilcoxon test.

Results : The results showed that the most age in patients with type 2 diabetes mellitus is between the ages of 50-59 years (80%). Gender is most women than men, as many as 35 participants (70%. The blood sugar level of type 2 diabetes mellitus patients’ before giving black glutinous water soaking was 262.72 mg / dl, until the third week there was a significant change, where the blood sugar level had an average of 132.02 mg/dl. The statistical test results obtained between blood sugar levels up to the third week had a p-value <0.05, which is 0.00, it showed that there was an effect of giving black glutinous water soaking to a decrease in blood sugar levels in patients’ with type 2 diabetes.

Conclusions : Based on this, it is recommended that the provision of black glutinous rice is one of the non pharmacological references in the implementation method of reducing blood sugar levels in clients with type 2 DM.
Analysis of maternal health service problems in the maternal and child health (KIA) program of the Konawe District Health Office
Authors: Anasari Wa , Suhartati Suhartati , Arbiyah Arbiyah , Wahyuni Eka i Syafitri , Hastati Sitti
Published: June 2022

Background: One form of service in the MCH program is services for pregnant women which consist of health services for pregnant women, maternal health, postpartum health, handling of obstetric complications, and contraceptive services, all of which aim to ensure protection for pregnant women and / or fetuses. This is closely related to efforts to reduce maternal mortality (MMR).

Objectives: The research objective was to determine the priority of health problems, find the root of health problems and provide alternative solutions to problems in health care for pregnant women

Methods: The research method used is descriptive research using secondary data sources to determine the priority of the problem by means of a Focus Group Discussion (FGD) involving decision makers at the Konawe District Health Office. The formulation of alternative solutions is carried out after the root causes are identified using Ishikawa or Fishbone diagrams. The priority of the root cause of the problem is carried out using the Capability Accessibility Readiness Leverage (CARL) method. Results: The results show that the low K1 and K4 coverage of pregnant women health services is the main priority problem. The root cause of the problem that must be prioritized to be resolved is that socialization to teenagers / prospective brides (catin) about marriage at a young age is still a major problem that must be followed up. The alternative that is given as a solution is to provide counseling using innovative and attractive media to make it easier to understand.

Conclusions: The priority of health problems in the MCH Program of the Konawe District Health Office is the problem of health services for pregnant women with K1 and K4 coverage. The root of the problem of socialization among adolescents / catin about marriage at a young age is still lacking is the level of education, knowledge, employment, counseling media are less innovative and interesting, the frequency of counseling and the size of the area are not proportional to the available resources. An alternative solution is socialization to teenagers/catin about marriage at a young age is still lacking by using innovative and interesting counseling media so that it is easy to receive and understand the information conveyed.
Analysis of implementation prevention protocols and community compliance with covid-19 event numbers
Authors: Ajeng Atnesia , Wahidin Wahidin , Oktaviani Ika
Published: June 2022

Background: The Covid-19 pandemic has shaken the world community and disturbed all aspects of human life, for this reason our efforts need to be carried out as an effort to prevent and overcome this pandemic so that it will pass quickly. Therefore, it is necessary to implement health and compliance protocols in the community.

Objectives: The aim of this research is to determine the implementation of COVID 19 prevention protocols and community compliance with covid-19 events in  Public Health Center
Methods:  This research was conducted using regression analysis, correlation and factor analysis. The subjects in this research activity are people who need services at the Puskesmas according to the inclusion and exclusion criteria. The object under study is the community's compliance with the Covid-19 prevention protocol implemented in Tangerang City. A sample of 150 people from 6 Puskesmas in the Tangerang City area in October-November 2020. The main instrument is a questionnaire which is carried out through a blended system approach where research is carried out directly and indirectly in the field, raw data is processed with the help of SPSS and AMOS.
Results: it can be seen that the implementation of the health protocol in the Public Health Center in the Tangerang city area has been running quite well  about 58.7%, but the level of compliance of the people of the city of Tangerang is still relatively low about 59.3%, however the incidence rate of Covid-19 in Public Health Center in the city of Tangerang is relatively low namely 70.7%. 
Conclusions: With the knowledge of the above, it is hoped that the local government and other stakeholders can find out and make the basis of facts in making decisions for further handling in order to accelerate the completion of the Covid-19 pandemic.