bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMANFAATAN BIJI Nigella sativa DALAM TERAPI PENYEMBUHAN KANKER DAN GANGGUAN METABOLISME
Authors: Jamil Ahmad Shobrun
Published: January 2019

The seed of Nigella sativa has long time ago employed as medicinal remedy for numerous disorders. N.sativa has active compounds in its seed likes nigellisine, nigellidine, nigellimine-N-oxide, thymoquinone, dithymoquinone, thymohydroquinon, nigellone, thymol, arvacrol, oxy-coumarin, 6-methoxycoumarin, 7-hydroxy-coumarin, alpha-hedrin, steryl-glucoside, flavonoids, tannins, essential amino acid, ascorbic acid, and minerals. The seed has various curative activities. As body immunity stimulator by stimulating the formations of bone marrow and many kind of antibody cells, antihistamine, anti-hypertension, anti-inflammation, antimicrobial activities by protecting bodies from viruses and decreasing the risk of infections, anti-diabetic (metabolic syndrome), and anti cancer. These papers have to discuss deeper about the beneficial aspect of N. sativa seed against metabolic syndrome and cancer. Based on several research known that N. sativa has potential to decrease total cholesterol, low density lipoprotein and blood glucose level. This seed also has potential to maintain the homeostatic of blood vessels as the backbone of the circulatory system in the body. At the cancer case, this seed substances has potential to decreasing the development of cancerous cells, kills the cells by enhances its apoptotic programs and also lessening the metastasis of the cancer cells. Keywords: cancer, metabolic syndrome, Nigella sativa
PENGARUH SARI SEDUH TEH HITAM (Camelia sinensis) TERHADAP PENGHAMBATAN PPAR γ SEL ADIPOSA JARINGAN LEMAK VISERA Rattus norvegicus STRAIN WISTAR
Authors: Herlina Elan , . Fatchiyah , Indra Rasjad
Published: January 2019

Penelitian bertujuan mengetahui pengaruh sari seduh teh hitam terhadap pengekspresian PPAR ã sel adiposa jaringan lemak visera Rattus norvegicus strain Wistar. Duabelas ekor tikus (Rattus norvegicus strain Wistar) jantan umur 6-8 minggu, berat 200 gram, diberi 4 macam perlakuan, yaitu A (diet tinggi lemak + SSTH 0 g/hari), B (diet tinggi lemak + SSTH 0,015 g/hari), C (diet tinggi lemak + SSTH 0,030 g/hari) dan D (diet tinggi lemak + SSTH 0,045 g/hari) selama 90 hari. Setelah masa perlakuan, tikus dibedah dan diambil lemak viseranya. Jaringan tersebut kemudian dibuat preparat dengan metode parafin. Jumlah sel yang mengekspresikan PPAR ã dianalisis dengan menggunakan pewarnaan immunohistokimia dan untuk mengkonfirmasi bentuk sel adiposa digunakan pewarnaan Hematoxylene&Eosin. Antibodi primer yang digunakan adalah anti PPAR gamma poliklonal antibody rabbit IgG dan antibodi sekunder biotin-goat-anti rabbit IgG. Hasil penelitian menunjukkan jumlah sel adiposa yang mengekspresikan PPAR ã mengalami penurunan seiring dengan penambahan dosis SSTH. Hal tersebut mengindikasikan SSTH dapat menurunkan pengekspresian PPAR ã pada sel adiposa jaringan lemak visera. Kata kunci: jaringan lemak visera, PPAR ã, diet tinggi lemak, sari seduh teh hitam
POLA PERESEPAN ANTIBIOTIKA PADA KASUS INFEKSI SALURAN PERNAFASAN AKUT (ISPA) DI KLINIK “X” DI KOTA MALANG PADA BULAN MEI-DESEMBER 2008
Authors: Hidayati Ika Ratna , Rachmawati Hidajah
Published: January 2019

Infeksi pada saluran napas merupakan penyakit yang umum terjadi pada masyarakat. Infeksi saluran napas berdasarkan wilayah infeksinya terbagi menjadi infeksi saluran napas atas dan infeksi saluran napas bawah. Infeksi saluran napas atas meliputi rhinitis, sinusitis, faringitis, laryngitis, epiglotitis, tonsillitis, otitis. Sedangkan infeksi saluran napas bawah meliputi infeksi pada bronchus, alveoli seperti bronchitis, bronkhiolitis, pneumonia. Penelitian ini dimaksudkan untuk melihat gambaran pola peresepan antibiotik pada kasus infeksi saluran pernapasan akut (ISPA) di Klinik “X” di Kota Malang pada bulan Mei-Desember 2008. Pengambilan data dilakukan secara retrospektif pada periode Mei sampai Desember 2008 di sebuah klinik “X” di Kota Malang, Jawa Timur. Semua pasien dengan semua jenis umur dan yang tercatat di dalam rekam medik di ambil sebagai sampel. Analisa dilakukan dengan metode deskriptif non analitik. Hasil penelitian menunjukkan bahwa dari 166 kasus infeksi saluran pernapasan akut, 69,87% diantaranya pasien wanita, sedangkan sisanya 30,12% adalah laki-laki. Antimikroba yang paling banyak digunakan adalah sefadroxil sebanyak 51,20%, dan diikuti berturut – turut antibiotika Ciprofloxacin sebanyak 22,89%, Amoxicillin sebanyak 12,05%, Cotrimoxazol sebanyak 6,02%, Thiamphenicol sebanyak 4,82%, Erythromycin sebanyak 2,4%, dan paling rendah adalah antibiotika Chloramphenicol sebanyak 0,60%. Secara umum pemilihan dan penggunaan antimikroba untuk terapi pada pasien infeksi saluran pernapasan akut di Klinik “X” di Kota Malang, propinsi Jawa Timur bulan Mei-Desember 2008 sudah sesuai dengan referensi standar pelayanan kefarmasian. Kata kunci : antibiotika, infeksi saluran nafas, pola peresapan
UJI AKTIVITAS EKSTRAK BUAH MERAH (Pandanus conoideus) SEBAGAI HEPATOPROTEKTOR PADA HATI MENCIT GALUR SWISS YANG DIINDUKSI DENGAN CCl4
Authors: Maulita Arina Swastika
Published: January 2019

Liver is an the important organ, it plays an essential role in maintaining the biological equilibrium of vertebrates. Reactive oxygen species (ROS) play an important role in pathological changes in the liver. The research has been carried out to know the potential use of buah merah (Pandanus conoideus) extract as hepatoprotrctive agent against CCl4 poisoning in mice. In this study, the hepatoprotective activity was determined by the reduction of SGPT (serum glutamic pyruvate transaminase) and SGOT (serum glutamic oxaloacetic transaminase) level. Application of buah merah extract significantly (p< 0,05) reduced SGPT and SGOT level. Microscopically, several changes were found, such as severe hydrofic degeneration and necrosis at liver cell that treated by CCl4. Base on histological examination of application of buah merah extract, could inhibit damage and reduced the degeneration and necrosis of liver cell. Keywords: buah merah, SGPT, SGOT, hepatoprotective.
AKTIVITAS SITOTOKSIK EKSTRAK ETANOLIK HERBA CIPLUKAN (Physalis angulata L.) PADA SEL KANKER LEHER RAHIM HeLa MELALUI MODULASI EKSPRESI PROTEIN p53
Authors: Darma Andita Pra , Ashari Rosana Anna , Nugroho Perdana Adhi , Monikawati Ameilinda , Fauzi Ilham Agusta , Hermawan Adam , Meiyanto Edy
Published: January 2019

Cervical cancer is one of leading cause of cancer death in women in the developing countries. One of the strategy to prevent cervical cancer based on cytotoxic agents are now being developed. Ciplukan (Physalis angulata L.) is one of potential plant as chemopreventive agent due to Physalin and Withangulatin constituent in this plant. This study was aimed to know cytotoxic effect  of ciplukan ethanolic extract (CEE) in human cervical carcinoma Hela cell line. Evaluation of cell viability value was determined using MTT assay. The expression of p53 as cell proliferation regulator was observed with immunocytochemistry assay. Ethanolic extract of ciplukan showed cytotoxic effect in HeLa cell line with IC50 of 158 µg/ml. Further observation of cell proliferation regulator showed that CEE induces expression of p53 that inhibit cell proliferation. The result showed that CEE has potential activity to be developed as anticancer agent in human cervical cancer.
PROFIL PENDERITA KANKER PAYUDARA STADIUM LANJUT BAIK LOKAL MAUPUN METASTASIS JAUH DI RSUP HASAN SADIKIN BANDUNG
Authors: Sander Mochamad Aleq
Published: January 2019

Breast cancer represent one of the most second malignancy of the woman after cervix cancer. In Indonesia estimated ±100 new case per 100.000 population every year, meaning more or less 200.000 new case every year to all cancer type. While for the breast cancer ± 23.140 new case every year. If breast cancer found in early stage, it has high life expectancy, ranging from 85-95%. But actually 70-90% patient came to hospital after their disease were hard and advanced stage. Cancer medication at advanced stage was very difficult and its result very dissatisfactory. The aim of research is to know the epidemiology, clinical symptom, diagnosis, therapy, prognosis. Descriptive study with retrospective design. Total sampling was all outpatient in oncology deparment of Hasan Sadikin Hospital of Bandung with advanced stadium of breast cancer from January 2003 up to December 2008. 164 eligible respondens who had age below 35 yo 28 (17.1%) and above 35 yo 136 (82.9%). Average of menarche 11.77 yo. Location of right breast cancer 78 (47.6%), left 82 (50%), and both 4 (2.4%). A lot of stadium was T4bNoMx that is 18 (11%). Chest x-ray, laboratory, and USG were the most diagnostic procedure often used that is 19 (11.6%). The most common therapy was BE+VC+RM that is 17 (10.4%). The prognosis was healing 20 (12.2%),  not/not yet healed 30 (18.3%), not control 110 (67.1%), and who control in the other place 4 (2.4%). Conclusion was mostly diagnosis of breast cancer according to anatomy pathology, chest x-ray, laboratory, and ultrasonografi. A lot of breast cancer location was left side. Excision biopsy, and followed by radical mastectomy were the most therapy procedure. Therapy evaluation to assess the level of healing was difficult because most patient did not conduct the control after therapy.
PENGARUH IKLAN OBAT FLU DI TELEVISI TERHADAP PEMILIHAN OBAT SECARA SWAMEDIKASI PADA MASYARAKAT DI MALANG
Authors: Rachmawati Hidajah
Published: January 2019

Communications is process transfer of information signing the forwarding of message of someone to others, either through indirect and also direct that is media.Television as a mass media technically capable of informing public in numerous amount in the same time. One of television program offering various product to fulfill requirement and satisfaction of physical is commercial. Such commercial is influenza drug commercial, because met many people. This matter of tendency make people to do self-medication as solving of from problem of health which they recognize by self.             Data collecting uses purposive sampling method in 102 respondents . Instrument test is done by validity test and reliability testing . Data analysis tool used is correlation analysis,t-test and regression analysis. Based on the result of the research, correlation coefficient is 0.645 so r table is 0,195, means there is a relation between influenza drug commercial and self-medication drug of choice. Based on the test t, t calculation is 2,376 so t table is 1,980, means there is influenza drug commercial in television has significant effect to self-medication drug of choice with equation regression Y = 4.803 + 0.522 x, means if influenza drug commercial in television indicator increasing 1 so self-medication drug of choice increasing 0.522. Value Sig. Of 0.000 <0.05 then the correlation coefficient deduced influenza drug commercial to self medication ‘s drug of choice in people in Malang is significant.
STRUMA MULTI NODOSA NON TOKSIKA INTRATHORAKAL Apa pilihan approach operasinya? Haruskah dilakukan Median Sternotomy?
Authors: Sander Mochamad Aleq , CS Fina
Published: January 2019

Mochamad Aleq Sander, dr., M.Kes., SpB., FinaCSFakultas Kedokteran Universitas Muhammadiyah MalangJl. Bendungan Sutami 188A Malang 65145e-mail: aleq.sander@yahoo.comblog: bedahunmuh.wordpress.comAbstractIntrathoracal non toxic multi nodular struma is lumpy enlargement of thyroid glandwithout hypothyroidism that extend from cervical thyroid gland into thoracal cavity. Accordingto anatomy location of thyroid, their name were substernal, retrosternal, mediastinal,intrathoracal, plunging, anterior and posterior mediastinal, and aberrant mediastinal. Theorigin of blood supply of mediastinal struma was inferior thyroidea artery, especially casesfrom aorta, subclavia artery, internal mammary artery, or ima thyroidea artery. According toStudy got that seven patients with mediastinal struma had intrathoracal blood supply directly.Surgery could cervical approach and/or thoracotomy according to anatomic location andtype of intrathoracal struma.Keywords: intrathoracal strumaAbstrakStruma multi nodosa non toksika intratorakal adalah pembesaran kelenjar tiroid yang tampakberbenjol-benjol tanpa disertai tanda-tanda hipertiroidisme yang mengalami ekstensi kearahinferior dari kelenjar tiroid servikal hingga masuk ke dalam rongga thoraks. Jaringan tiroidyang berada di rongga toraks diberi nama sesuai tempat anatominya yaitu substernal, retrosternal,mediastinal, intrathorakal, plunging, anterior dan posterior mediastinum, serta mediastinumaberrant. Suplai darah untuk struma mediastinum biasanya dari arteri tiroidea inferior, padakasus tertentu suplai darah dapat berasal dari aorta, arteri subklavia, arteri mamaria interna,atau dari arteri tiroidea ima. Hasil penelitian didapatkan bahwa dari tujuh orang yang mengalamistruma mediastinum ternyata memiliki sumber perdarahan langsung dari intrathorakal. Tindakanoperasinya bisa melalui cervical approach dan/atau thoracotomy, hal ini tergantung dari lokasianatomis dan tipe struma intratorakal yang diderita oleh pasien.Kata kunci: struma intratorakal
Evaluasi Efektivitas dan Keamanan Penggunaan Obat Anestesi Umum di RS PKU Muhammadiyah Yogyakarta
Authors: Inayati Istiqoma Dewi Kurniawati Zullies Ikawati
Published: January 2019

Anesthesia is given to more than 75 million surgical patients annually, wordwide. An ideal anesthetic drug would induce anesthesia smoothly and rapidly while allowing for prompt recovery after its administration is discontinued. The drug would also prossess a wide margin of safety and be devoid of adverse effects. The objective of the study was to get an overview on use of general anesthesia at PKU Muhammadiyah hospital, Yogyakarta which included aspects of dose induction relevance, effectiveness of general anesthesia based on onset dan duration recovery and safety based on cardiovascular and respiratory side effects which happened due to induction anesthesia.The study used descriptive case series design carried out prospectively. Data were obtained from observation of elective surgery patient in Instalasi Bedah Sentral at PKU Muhammadiyah hospital, Yogyakarta. Sample were collected by concecutive sampling methods on Maret-Juni 2010. Onset, duration recovery were monitored after induction anesthesia. Systolic and diastolic blood pressure, heart rate, saturation were monitored 0 minute before induction and 5 minute after induction anesthesia.From 84 patient, as many as 72,62%  were relevant dose with induction and 27,38% were irrelevant dose. Effectivity anesthesia based on onset was 100% effective Recovery from isoflurane was 4-11 minute faster than with sevoflurane and 1-4 minute faster than hallotane. Cardiovascular side effect was not significant between relevant and irrelevant dose Induction. No respiratory side effect was found.
Efek Ateroprotektif dan Vasoprotektif Katekin Teh Hijau terhadap Ekspresi eNOS pada Tikus Wistar Jantan dengan Diet Tinggi Lemak
Authors: Retty Ratnawati Erna Susanti
Published: January 2019

Catechins , isolate from green tea  GMB4 clones could be developed as a potential preventive agent for atherosclerosis. This activity is thought to be based on the structure epimerisation, hydroxy phenolic  and galloil group of these isolates. The purpose of this study is to prove the influence catechins ,isolate from green tea, on the inhibition of the decrease eNOS expression in male wistar rats induced by  high  fat diet. The method used in this study consisted of ELISA for measurement of eNOS expression. The results showed that  catechins inhibits the decreasing expression of eNOS at a dose of 6 mg / day and 24 mg / day was significantly but not dose 3mg / day. This suggests a dose 6mg / day and 24 mg / day is able to repair the damage signaling insulin on PI3K pathway caused by insulin resistance. These results are based on the ability of catechins as antioxidants. Catechins with hydroxy phenolic group  is a potential electron donor to bind  free radicals. Polyphenol catechins may also modulate  signaling cellular processes such as NFkâ, activator protein 1 DNA binding, glutathione biosynthesis, PI3K / Akt, MAPK pathway and the Nrf2 transcription factor that regulates expression of several antioxidant genes. It can be concluded catechins  inhibits  decreasing expression of eNOS  at a dose of 6 mg / day and 24 mg / day and can be developed as an agent and vasoprotective ateroprotective.
PROFIL KEPATUHAN PENGGUNAAN OBAT HIPOGLIKEMIK ORAL GLIBENKLAMID (Pada Pasien Diabetes Mellitus Tipe 2 di Puskesmas Kedungkandang Malang)
Authors: Hidajah R Masita Rinaldia
Published: January 2019

Indonesia is one of the developing countries and  listed as number seven rank in the world as a country with problems with the disease. Increasing prosperity in developing countries and changes in lifestyle lead to increased prevalence of degenerative diseases one of them with diabetes mellitus (DM). Patients with diabetes mellitus need support from other families also need support from professionals in the health sector such as doctors, nurses, pharmacy. With the support - support that is given so that it can improve the quality of life of people and with diabetes mellitus.             This study aimed to profile the compliance in the use of oral hypoglycemic glibenclamide. This research was conducted using descriptive research design. Samples were taken from patients with type 2 diabetes mellitus patients in health centers Kedungkandang Malang. Research done by giving questionnaires and visits from the remaining drug count glubenklamid obtained.             From the description of the questions is obtained for 73.3% never received an explanation from the pharmacist and 70% of patients did not request an explanation from the pharmacist. Amounted to 86.7% of patients knew the use of drug glibenclamide. 56.7% of patients returned to the clinic every drug out and amounted to 50% of patients received support from family. Patients using the drug each day with a percentage of 53.3% and 66.7% of information on how to read and drink a patient using the drug in accordance with the percentage dose of 70% and use drug the morning before eating with a percentage of 46.7% and 63.33% and patients who never experienced drug side effects of 76.7%. From the calculation of drug remaining is calculated from the sum of all the samples showed results of 83.3% compliance. So the usage of drug compliance glibenclamide in patients with type 2 Diabetes in Primary Health Care Melllitus Kedungkandang Malang by 83.3%.
Pengembangan Matrik Lepas Lambat Berbasis EC – PVP K30 Menggunakan Teknik Dispersi Solida Dengan Model Obat Natrium Diklofenak
Authors: Arina Swastika Maulita Yulistia Budianti Soemarie
Published: January 2019

This research is a modification of controlled release which beneficially to optimize the medicine reaction and to minimize the fluctuation of blood level in a certain period of the release. The aim of research is to develop the matrix  system in ethylcellulose basic PVP K30 which applies dispersion solid method using sodium diclofenac as sample. Resulted four formulas consist of PVP K30 percentages as follow 0%, 5%, 10% and 20%. The different percentages of PVP K30 is aimed to know the formula which produces the releasing result of ND more optimal. This research produces in each formula significant differences (p<0,05). The formula whole percentages of PVP K30 10% has completed the requirements of control release better than the other one, shown the better resistance characteristics and release profile.
Algumas fontes cristãs que inspiraram a concepção de mundo e de ação em Paulo Freire
Authors: Coelho Edgar Pereira , De Mari Cezar Luiz , Meucci Arthur
Published: January 2019

O presente ensaio propõe novas reflexões sobre as influências teológicas cristãs que inspiraram os valores morais e as visões de mundo que encontramos nos textos teóricos de Paulo Freire. As notas de rodapé, referências bibliográficas, cartas e entrevistas, revelam seu constante diálogo com teóricos do cristianismo, especialmente os envolvidos com a Teologia da Libertação. Freire não via conflito entre o materialismo “mundano” de Karl Marx e a “transcendentalidade” proposta por Jesus Cristo, o que permite a elaboração de um sincretismo teórico para repensar os aspectos éticos e conceituais da atuação do educador. A originalidade religiosa do pensamento freiriano permite uma práxis educadora a partir das experiências cotidianas e suas contradições.
Pedagogia do oprimido (1968-2018): da revolução ao reencontro da esperança
Authors: Scocuglia Afonso Celso
Published: January 2019

Este artigo incide sobre os 50 anos do livro “Pedagogia do oprimido”, de Paulo Freire, concluído fora do Brasil em 1968 e publicado em 1970. Considera o livro como núcleo articulador de uma obra complexa, polifônica e em construção/reconstrução permanente. Deste prisma, como declarado por Freire, faz parte de uma trilogia que começa com a sua tese acadêmica de 1959 (Educação e atualidade brasileira), continua em “Educação como prática da Liberdade” (1965) até desaguar no livro em tela. E pode se dizer que continua em outras obras posteriores, a exemplo de “Ação cultural para a liberdade e outros escritos” (1970). Considera-se, também, o fato de que seu autor pretendeu reescrevê-la e o fez, em parte, nos livros “Pedagogia da esperança - um reencontro com a Pedagogia do oprimido” (1992) e “Política e educação” (1993). Nesta reescrita, quase 25 anos depois, Freire refez conceitos, apostou em outro paradigma, descartou personagens e ênfases do livro de 1968, demonstrando o permanente movimento de reconstrução epistemológica marcado pelas circunstâncias históricas das suas práticas político-pedagógicas no Brasil, na América Latina, nos Estados Unidos, na Europa, na África.
A gênese do mito: a ideia de excelência e a criação do Colégio Universitário da UFV
Authors: Germano Hollerbach Joana D'Arc
Published: January 2019

Este artigo tem por objetivo discutir o processo de criação e consolidação do COLUNI – Colégio Universitário da Universidade Federal de Viçosa. O recorte estudado compreende o período entre 1965, quando o Colégio foi criado, e 1981, último ano em que ofertou apenas o terceiro ano do segundo grau. A pesquisa teve por método a pesquisa histórica, mediada pelo materialismo histórico dialético, pautada em fontes documentais primárias. A criação do COLUNI tinha por objetivo preparar os jovens candidatos aos cursos superiores da então Universidade Rural do Estado de Minas Gerais (UREMG), tendo em vista a defasagem acadêmica trazida por esses jovens do ensino secundário. A busca pela excelência no ensino superior era o mote que orientava a organização do Colégio, justificando sua existência mesmo depois da revogação do artigo 79, da Lei 4.024/61. Discutimos como a ideia de excelência acompanhou o primeiro período de existência do Colégio, a despeito das dificuldades encontradas nos primeiros anos.
METABOLIC PSEUDOPROGRESSION AS NEW PHENOMENON ON [11C]METHIONINE PET/CT DURING TREATMENT MONITORING OF PATIENTS WITH MALIGNANT CEREBRAL GLIOMA
Authors: Skvortsova T. Yu. , Savintseva Zh. I. , Gurchin A. F. , Trofimova T. N.
Published: January 2019

With improved treatment for cerebral gliomas leading to longer survival, late rare complications of radiation therapy on the brain are more frequently observed. The paper presents the results of positron emission tomography (PET) with [11C]methionine in 4 patients with malignant cerebral glioma, in whom the phenomenon of transient diffuse high [11C]methionine uptake in the cerebral cortex was detected during treatment monitoring. The unilateral high [11C]methionine uptake in the posterior portion of the cerebral hemisphere was stereotyped and easy to recognize. Nevertheless high amino acid uptake on PET did not match with structural abnormalities on MRI and was not accompanied by aggravation of neurological symptoms or by epileptic seizures. The results of the follow-up examinations excluded tumor recurrence. The control PET/CT scans showed complete resolution of the abnormal [11C]methionine uptake. The clinical and instrumental similarity of the presented cases allowed to establish the diagnostic criteria for the phenomenon of metabolic pseudoprogression and to compare them with the criteria of the SMART syndrome (stroke-like migraine attacks after radiation therapy). Two cases with SMART syndrome are presented as a comparison group. The similarities and discrepancies of unusual metabolic hyperfunction with previously known phenomena and possible mechanisms for their development are discussed. It is important for clinicians and radiologists to be aware of the characteristic imaging findings of the metabolic pseudoprogression on PET with [11C] methionine to avoid overdiagnosis of the brain tumor recurrence and aggressive treatment approach.
COMPARATIVE ANALYSIS OF DUAL ENERGY X-RAY AND BIOIMPEDANCE ANALYSIS IN THE ASSESSMENT OF COMPONENT COMPOSITION OF THE BODY OF HAEMODIALYSIS PATIENTS
Authors: Jakovenko A. A. , Shestopalova O. Y. , Rumyantsev A. Sh. , Somova V. M.
Published: January 2019

The aim of the study. Compare the efficiency of the use of dual-energy x-ray absorptiometry (DRA) and bioimpedansometry (BIM) in the evaluation of the body composition of hemodialysis patients.

Patients and methods. 67 patients on hemodialysis, among which 23 men and 44 women aged 54±14,4 years. BIM and DRA were used to evaluate the body composition.

Results. The results of determining the total muscle mass of the body obtained by the results of DFA and BIM were compared with the use of the Bland-Altman method. The correlation coefficient between the indices was R=0,994, p<0,0001, delta (M±s) was –0,48±0,91 kg, CI 95% (–0,71)…(–0,26) kg.

Conclusion. DRA does not have significant advantages over tetrapolar multifrequency BIM when assessing the body composition in hemodialysis patients.
Los genes como marcadores de riesgo en cáncer gástrico: revisión de estudios en población colombiana
Authors: Yáñez-Gutiérrez Claudia Marcela
Published: January 2019

El objetivo de esta revisión, fue identificar el rol de los genes como marcadores de riesgo en cáncer gástrico (CG) en población colombiana. Se revisaron publicaciones de investigaciones realizadas en los últimos diez años, utilizando las bases MEDLINE y LILACS y complementando  la pesquisa con la bibliografía relevante de los artículos. Se encontraron estudios en busca de asociación de CG con polimorfismos de varios genes humanos involucrados en la respuesta inmune, la desintoxicación y el supresor p53. En Colombia al igual que en otros países, las evidencias de asociación de polimorfismos genéticos con CG son aún controversiales, debido a la variación de los resultados que arrojan los estudios en las diferentes poblaciones. El genoma de las cepas de Helicobacter pylori que infectan población colombiana también ha sido investigado en búsqueda de polimorfismos de virulencia. El genotipo cagA/vacAs1m1 identificado como citotóxico en esta bacteria, mostró en la mayoría de las investigaciones, asociación con CG. La evidencia de asociación de CG con factores genéticos en población colombiana no es concluyente. Está lejos aún, la identificación de marcadores genéticos que permitan predecir el riesgo a desarrollar CG. A pesar de ello, algunos polimorfismos de genes humanos como los de IL-1 o los de algunas enzimas desintoxicantes, así como los genes cagA y vacA de Helicobacter pylori podrían ser candidatos a futuros marcadores de riesgo en esta neoplasia.Palabras clave: cáncer gástrico, riesgo, genotipo, Colombia. ABSTRACT  The objective of this review was to identify the role of genes as risk markers in gastric cancer (GC) in Colombian population studies. The study reviewed research publications in the last ten years, using the MEDLINE and LILACS, as well as various literature research of relevant articles. Searching studies found GC association with several human gene polymorphisms involved in the immune response, detoxification and suppressor p53. In Colombia, as in other countries, the evidence of the association of genetic polymorphisms with GC are still controversial because of the variation in results that studies in different populations. The genome of Helicobacter pylori strains that infect Colombian population has also been investigated in search of polymorphisms of virulence. cagA/ vacAs1m1 genotype identified as cytotoxic in this bacterium, demonstrated most of the research associated with GC. Evidence of association of GC with Colombian population genetic factors was inconclusive. It is yet to be determined the exact identification of genetic markers that can predict the risk of developing GC. However, some human gene polymorphisms as IL-1 or some detoxifying enzymes and the vacA and cagA of H. pylori could be candidates for future risk markers in these tumors.Keywords: gastric cancer, risk, genotype, Colombia
Evaluación de la motilidad espermática a través del sistema C.A.S.A de semen caprino criopreservado bajo diferentes medios diluyentes
Authors: Hernández-Corredor Leonardo , Nivia-Osuna Alexander , Hernández-Villamizar Daniel , Rubio-Parada Jorge Alexander , Quintero-Moreno Armando
Published: January 2019

El estudio evaluó la motilidad espermática y su efecto postdescongelación en semen caprino, en dos medios comerciales (Andromed® y TwoStep®) y diferentes protocolos de congelación (medio completo, con adicción del 10% de yema de huevo, semen centrifugado y sobrenadante seminal), se utilizaron machos de la raza alpina de la Universidad Francisco de Paula Santander Ocaña, el semen fue colectado con electroeyaculador, una vez los medios terminados y parte de los contenidos seminales enteros o centrifugados mezclados, se estabilizó por 2 horas, se envasó en pajillas de 0,5 cc y se congela en vapores de nitrógeno por 10 minutos, las pajillas se llevaron al laboratorio de Andrología de la Universidad del Zulia y por medio del sistema C.A.S.A.(Computer Assisted Sperm Análisis) se evaluaron los parámetros de motilidad como velocidad curvilínea (VCL), velocidad rectilínea (VSL), velocidad lineal (VAP), índice de linealidad (LIN), índice de rectitud (STR), índice de oscilación (ALH), Amplitud media del desplazamiento lateral de la cabeza del espermatozoide (BCF), los datos fueron analizados por medio del procedimiento GLM de SAS versión 9.0; los mejores índices de motilidad (VCL, ALH, BCF) fueron expresados enel tratamiento de contenido seminal centrifugado en medio Andromed®. (p≤0,001))La mejor progresividad espermática (VSL,LIN,STR)se presentó el tratamiento de Semen completo de caprino, criopreservado en medio comercial TwoStep®. ABSTRACT  The study evaluated the effect sperm motility and sperm post-thawing in goats, two commercial means (Andromed ® and Two Step ®) and different freezing protocols (complete medium with 10% addition of the egg yolk, semen centrifuged supernatant and seminal ), we used males of the Alpine race of the University Francisco de Paula Santander Ocaña, semen was collected with electroejaculator once finished media and part of the whole and centrifuged seminal contents mixed, stabilized by two hours, packed in 0.5 cc straws and frozen in nitrogen vapor for 10 min, the straws were taken to the laboratory of Andrology at the University of Zulia and through CASA system (Computer Assisted Sperm Analysis) were evaluated motility parameters such as curvilinear velocity (VCL), straight line velocity (VSL), linear velocity (VAP), linearity index (LIN), straightness index (STR) Oscillation Index (ALH ) average amplitude of the lateral displacement of the sperm head (BCF), the data were analyzed by the GLM procedure of SAS version 9.0, the highest rates of motility (VCL, ALH, BCF) were expressed in the treatment of seminal content centrifugation Andromed ® medium. (p ≤ 0.001)) The best progressive sperm (VSL, LIN, STR) will present the full Semen treatment goats, cryopreserved at Two Step ® commercial medium.Keywords: semen, buck, Andromed, Two step.
Does the existence of ethics and compliance committees improve stock market and financial performance?
Authors: Holcomb John , Grove Hugh , Clouse Maclyn
Published: January 2019

The major research question, in the title of this paper, was answered positively for stock market performance. The companies with Ethics and Compliance Committees (ECC) outperformed the non-ECC companies on five-year annual averages for both profit margin and net income growth rate, which may mean Wall Street investors are emphasizing non-financial performance indicators, as well as long-term financial performance indicators. Results are somewhat mixed, as investors rewarded ECC companies with superior stock market performance versus other financial measures, like returns on equity and assets, which were better for non-ECC companies. The empirical analysis in this paper relied upon prior research which had conducted content analysis of the 2015 charters of all the board committees of the Fortune top 200 corporations (Holcomb, 2017). This prior research identified 11 companies which had board committees with ethics and compliance duties, versus the Fortune top 20 companies, which delegated such duties to their audit committees. The empirical research in this paper has shown that the Ethics 11 companies outperformed the Fortune top 20 companies over the 2013-2017 period, primarily in the key stock market performance measure of the percentage change of the market capitalization from the end of 2013 until the end of 2017.
Understanding the Role of Internship as an Activity Based Learning: A Case Study
Authors: Ali Aasir , Khushi Arshad
Published: January 2019

Activity based learning is a successful educational model in various disciplines and recently it has been proved very effective in business institutes also. This paper was intended to explore the effects of internship in the university students of Pakistan as an activity based learning in order to boost their skills and abilities. Qualitative research as research design was adopted for the study following interpretivist paradigm. For the purpose of data collection, 30 students from business institutes were interviewed. Only those candidates were chosen who had recently completed their internship in well-known organizations of Pakistan. Data analyses were done through NVivo software version 11, suggested for qualitative data analyses. Findings proposed that industrial internship is a viable activity for the learning and growth of university students. Practical experience, teamwork, understanding strengths and weaknesses, financial support for further studies and exposure to real world problems were found chief outcomes of internship in terms of professional development. Likewise, goal setting, internal motivation, confidence, punctuality, regularity and understanding responsibility in terms of personality development were found as key outcomes of internship for business students. Keywords: activity based learning, business students, internships, professional development.
Gender Differentials Among Teachers’ Classroom Management Strategies In Pakistani Context
Authors: Ahmed Maqsood , Ambreen Munazza , Hussain Ishtiaq
Published: January 2019

The main purpose of this study was to get an insight about teachers’ classroom
management strategies and explore the gender differences among teachers’ classroomstrategies. The present descriptive study was quantitative in nature andmethod was used. All the teachers, teaching in different Islamabad Model
Schools for Boys and Girls, Islamabad (Urban Sector) constituted the population of the. Data were collected from a sample of 126 secondary school teachers, teaching in 10 different Islamabad Model Schools for Boys and Girls, Islamabad, Pakistan. Data were collected via Classroom Management Inventory (CMI), developed by the researcher, keeping in view the Pakistani context. As a result of pilot study, reliability test of the questionnaire reflected 0.947 value of Cronbach’s Alpha, which showed the high reliability of the instrument. From the findings of the study, it was concluded that teachers’ gender affects their classroom management. Female teachers exhibited more classroom management skills on four out of six dimensions of classroom management
than the male teachers. Classroom management being a challenging and complex task, demand knowledge and skills on the part of teachers. It is recommended that teacher trainings should contribute to such endeavour, keeping in view the gender differentials. 

Keywords: gender, differentials, classroom management, strategies
Editorial: 1º Congreso Mundial de Hospitalización a Domicilio
Authors: Massa Domínguez Beatriz
Published: January 2019

A veces…, las cosas tanto en el plano personal como profesional surgen casi “sin avisar”, y nos obligan a extremar la intuición para saber si el tren que pasa es el apropiado para nosotros y debemos subirnos, porque de otro modo la oportunidad se desvanecerá para siempre.A veces…, las cosas ocurren por casualidad, pero prefiero pensar que ésta no es otra cosa que la consecuencia postrera de un trabajo minucioso, concienzudo y con una orientación a objetivos clara.
Reduction of hexavalent chromium by Bacillus spp. isolated from heavy metals-polluted soil
Authors: Ilic Dora , Dimkic Ivica , Waisi Hadi , Gkorezis Panagiotis , Hamidovic Saud , Raicevic Vera , Lalevic Blazo
Published: January 2019

Hexavalent chromium, Cr(VI), one of the major pollutants from industrial facilities, is very toxic and harmful for human health and environmental quality. Due to the lack of conventional methods, bioremediation was recommended as an environmentally friendly and effective technique. The aim of this paper was the isolation, identification and selection of the microorganisms which are capable of Cr(VI) reduction in vitro. Heavy metal concentration, detected in four soil samples, within and around the former bicycle factory ?Rog? (Republic of Slovenia), was measured using the ICP-OES method. Bacteria were isolated and tested for chromium tolerance using LB agar supplemented with various Cr(VI) concentrations, whilst Cr(VI) reduction and bacterial growth was determined using the LB liquid medium. From 53 bacterial isolates, five of them showed a tolerance of 1000 mg/L of Cr(VI). Those five isolates showed the capability of growth under various Cr(VI) concentrations (50-1000 mg/L). Initial Cr(VI) concentrations ranging from 50 to 100 mg/L were completely reduced by four bacterial isolates, whilst 500 to 1000 mg/L by Bacillus safensis 342-9. Using 16S rDNA and tuf gene sequence analyses, isolates 270-9R and 342-9 were identified as Bacillus safensis, isolates 351-9 and 270-9C as Bacillus subtilis subsp. subtilis, and 212-9 as Bacillus thuringiensis. These results indicated that these bacteria may be promising tools for remediation of metal-polluted sites.
Improving the metabolisable energy value of brewers’ dried grains with enzyme cocktails in poultry nutrition
Authors: Jimoh Abdulhameed , Atteh Job
Published: January 2019

The determination of the positive effects of exogenous enzymes is essential
to ensure their inclusion in poultry feed formulation. This study was
conducted to determine the effect of enzymes on the apparent metabolisable
energy (AME) value of brewers? dried grain (BDG). Xylanase, phytase and
multipurpose enzymes were used in a completely randomised design to
determine the effects of individual exogenous enzymes and their cocktails on
poultry metabolisable energy using adult cockerels. There were eight
treatments comprising a control and seven experimental treatments with BDG
and one, two or three enzymes. The AME values were determined using the
intubation method. Data collected were analysed using the statistical
analysis system. Enzymes individually and as a cocktail improved the AME
value of BDG compared to the control. An increase in the AME value was
3.48%, 5.39%, 5.92%, 14.29%, 18.13%, 23.21% and 29.58% respectively for
phytase, xylanase, cocktail of xylanase and phytase, multipurpose enzyme,
cocktail of multipurpose enzyme and phytase, cocktail of xylanase and
multipurpose enzyme and cocktail of xylanase, phytase and multipurpose
enzyme. Cocktails of enzymes were significantly better (P?0.05) than
individual enzymes in their effects on apparent metabolisable energy of BDG.
Phytase gave a marginal increase in AME of the studied feedstuff. It has
been concluded that the cocktail of enzymes is better than individual
enzymes in their effects on AME of BDG. If different enzymes are available,
it is recommended that the enzyme with higher units should be used.
Bonding Interaction and Shrinkage Stress of Low-viscosity Bulk Fill Resin Composites With High-viscosity Bulk Fill or Conventional Resin Composites
Authors: Cerda-Rizo ER , de Paula Rodrigues M , Vilela ABF , Braga SSL , Oliveira LRS , Garcia-Silva TC , Soares CJ
Published: January 2019

Objective:

To analyze the shrinkage stress, bonding interaction, and failure modes between different low-viscosity bulk fill resin composites and conventional resin composites produced by the same manufacturer or a high-viscosity bulk fill resin composite used to restore the occlusal layer in posterior teeth.

Methods & Materials:

Three low-viscosity bulk fill resin composites were associated with the conventional resin composites made by the same manufacturers or with a high-viscosity bulk fill resin composite, resulting in six groups (n=10). The bonding interaction between resin composites was tested by assessing the microshear bond strength (μSBS). The samples were thermocycled and were tested with 1-mm/min crosshead speed, and the failure mode was evaluated. The post-gel shrinkage (Shr) of all the resin composites was measured using a strain gauge (n=10). The modulus of elasticity (E) and the hardness (KHN) were measured using the Knoop hardness test. Two-dimensional finite element models were created for analyzing the stress caused by shrinkage and contact loading. The μSBS, Shr, E, and KHN data were analyzed using the Student t-test and one-way analysis of variance. The failure mode data were subjected to chi-square analysis (α=0.05). The stress distribution was analyzed qualitatively.

Results:

No significant difference was verified for μSBS between low-viscosity bulk fill resin composites and conventional or high-viscosity bulk fill composites in terms of restoring the occlusal layer (p=0.349). Cohesive failure of the low-viscosity bulk fill resin composites was the most frequent failure mode. The Shr, E, and KHN varied between low-viscosity and high-viscosity resin composites. The use of high-viscosity bulk fill resin composites on the occlusal layer reduced the stress at the enamel interface on the occlusal surface.

Conclusions:

The use of high-viscosity bulk fill resin composites as an occlusal layer for low-viscosity bulk fill resin composites to restore the posterior teeth can be a viable alternative, as it shows a similar bonding interaction to conventional resin composites as well as lower shrinkage stress at the enamel margin.
Evaluación de programas de educación patrimonial en museos para personas con TEA / Evaluation of heritage education programs in museums for people with ASD
Authors: Pablos González Laura , Fontal Merillas Olaia
Published: January 2019

El presente artículo recoge el proceso de investigación desarrollado en torno a un estudio vinculado con el Observatorio de Educación Patrimonial en España (OEPE). Tomando como referencia las fuentes documentales que avalan el desarrollo de las disciplinas que fundamentan nuestro trabajo —la educación patrimonial, los museos y el trastorno de espectro autista (TEA) —, se observa la necesidad de incidir en la visibilización de propuestas de educación patrimonial desarrolladas en museos para personas con diversidad funcional, así como de fomentar la conversión de otros espacios en entornos inclusivos. En este sentido, el objetivo de este trabajo ha sido buscar, analizar e inventariar los programas de educación patrimonial existentes en España y destinados a personas con TEA. Para ello, y con base en el modelo SAEPEP-OEPE (Secuencia de Análisis y Evaluación de Programas de Educación Patrimonial) (Fontal, 2016), se han empleado una serie de instrumentos que han permitido no solo profundizar en el conocimiento de las experiencias analizadas, sino también determinar qué estándares de calidad suelen contener las propuestas de este tipo. Tras el proceso de recogida de información, se procedió a la selección de los instrumentos de análisis e interpretación, para lo cual se contó con una muestra de 27 programas desarrollados en museos para el colectivo objeto de estudio, de una población total de 1159 museos. De los datos extraídos en la citada muestra, se ha podido comprobar la necesidad de conocer las características del colectivo para poder adaptar tanto los métodos como los espacios, así como la prioridad de implicar a agentes externos y difundir el trabajo realizado. Entre las conclusiones clave para esta investigación destacan la escasez de propuestas existentes y la importancia del valor humano en todas las iniciativas analizadas.
Decisões didáticas e fatores que as influenciam no ensino de razões trigonométricas
 Didactic decisions and factors that influence them in the teaching of trigonometric reasons
Authors: Espindola Elisângela Bastos de Melo , Luberiaga Elida , Tragalova Jana
Published: January 2019

Apresentamos um estudo sobre as decisões didáticas de uma professora e a identificação de fatores que as originam em relação a seu trabalho documental para o ensino de trigonometria. Baseia-se o estudo na abordagem documental do didático; no modelo dos níveis de atividade do professor, na teoria antropológica do didático e no modelo de fatores decisórios. Seguindo os pressupostos da metodologia de investigação reflexiva, durante duas semanas, acompanhou-se o trabalho documental de uma professora sobre a elaboração de uma sequência e de uma aula de revisão sobre o ensino de razões trigonométricas. Os resultados apontam suas tomadas de decisões, desencadeadas por fatores epistêmicos (tipos de tarefas e de técnicas) ou relacionados à história didática (relação entre professora e alunos) sobre o ensino do tema.
This work aims to present an analysis of a teacher’s didactic decisions and the identification of factors that raised them in relation to her documentary work for the teaching of trigonometric ratios. The study is based on the documentary approach of didactics; the model of the teaching activity; the anthropological theory of teaching; and the model of factors that influence decision-making. Based on the assumptions of the reflective research methodology, the documentary work of a teacher on the elaboration of a sequence and a revision lesson on the teaching of trigonometry was observed during two weeks. The outcomes point out that her decision-making resulted from epistemic factors (types of tasks and techniques), or was related to the didactic history (the relationship between teacher and students) on the teaching of the topic.