bluuebunny/crossref_metadata_2025 huggingface dataset:
The active core microbiota of two high-yielding laying hen breeds fed with different levels of calcium and phosphorus
Authors: Roth Christoph , Sims Tanja , Rodehutscord Markus , Seifert Jana , Camarinha-Silva Amélia
Published: September 2022

The nutrient availability and supplementation of dietary phosphorus (P) and calcium (Ca) in avian feed, especially in laying hens, plays a vital role in phytase degradation and mineral utilization during the laying phase. The required concentration of P and Ca peaks during the laying phase, and the direct interaction between Ca and P concentration shrinks the availability of both supplements in the feed. Our goal was to characterize the active microbiota of the entire gastrointestinal tract (GIT) (crop, gizzard, duodenum, ileum, caeca), including digesta- and mucosa-associated communities of two contrasting high-yielding breeds of laying hens (Lohmann Brown Classic, LB; Lohmann LSL-Classic, LSL) under different P and Ca supplementation levels. Statistical significances were observed for breed, GIT section, Ca, and the interaction of GIT section x breed, P x Ca, Ca x breed and P x Ca x breed (p < 0.05). A core microbiota of five species was detected in more than 97% of all samples. They were represented by an uncl. Lactobacillus (average relative abundance (av. abu.) 12.1%), Lactobacillus helveticus (av. abu. 10.8%), Megamonas funiformis (av. abu. 6.8%), Ligilactobacillus salivarius (av. abu. 4.5%), and an uncl. Fusicatenibacter (av. abu. 1.1%). Our findings indicated that Ca and P supplementation levels 20% below the recommendation have a minor effect on the microbiota compared to the strong impact of the bird’s genetic background. Moreover, a core active microbiota across the GIT of two high-yielding laying hen breeds was revealed for the first time.
Cleome gynandra: A wonder climate-smart plant for nutritional security for millions in semi-arid areas
Authors: Mashamaite Chuene Victor , Manyevere Alen , Chakauya Ereck
Published: September 2022

Spider plant (Cleome gynandra) is predominantly used as a traditional leafy vegetable throughout Africa and is considered a rich natural source of essential nutrients such as vitamins, minerals and proteins. With the increase in malnutrition, diet related non-communicable diseases and poverty across the continent of Africa, the spider plant is a bona fide alternative healthy food crop to alleviate these challenges. Spider plant is an erect annual herb that could grow up to 150 cm tall, strongly branched, with a long taproot and few secondary roots. It is commonly consumed in resource-poor communities especially during times of major food scarcity. It is a drought-tolerant and resilient annual vegetable crop capable of growing well in a wide range of climatic and edaphic conditions. Despite the potential benefits and wide adaptability, progressive attempts towards the development of C. gynandra as a crop have been impeded by issues like low investment in research and development resulting in poor seed quality, relatively low yields and susceptibility to pests and diseases. In this paper, we reviewed the research that has been done regarding its morphology, growing conditions, production and utilisation (i.e., nutrition). The current review highlighted the status of the science in advancing the domestication of C. gynandra as a potential power crop for several African countries. The review concluded that with the advancement of modern biotechnology techniques and genome sequencing, there is a compelling case for investment and development in C. gynandra as a candidate for managing micronutrient deficiencies during the post-pandemic era. Finally, the existing knowledge gaps (e.g., breeding) that necessitate explorations were identified and recommendations that could enhance its development and potential commercialisation were made.
Multi-environment genome -wide association mapping of culm morphology traits in barley
Authors: Bretani Gianluca , Shaaf Salar , Tondelli Alessandro , Cattivelli Luigi , Delbono Stefano , Waugh Robbie , Thomas William , Russell Joanne , Bull Hazel , Igartua Ernesto , Casas Ana M. , Gracia Pilar , Rossi Roberta , Schulman Alan H. , Rossini Laura
Published: September 2022

In cereals with hollow internodes, lodging resistance is influenced by morphological characteristics such as internode diameter and culm wall thickness. Despite their relevance, knowledge of the genetic control of these traits and their relationship with lodging is lacking in temperate cereals such as barley. To fill this gap, we developed an image analysis–based protocol to accurately phenotype culm diameters and culm wall thickness across 261 barley accessions. Analysis of culm trait data collected from field trials in seven different environments revealed high heritability values (>50%) for most traits except thickness and stiffness, as well as genotype-by-environment interactions. The collection was structured mainly according to row-type, which had a confounding effect on culm traits as evidenced by phenotypic correlations. Within both row-type subsets, outer diameter and section modulus showed significant negative correlations with lodging (<−0.52 and <−0.45, respectively), but no correlation with plant height, indicating the possibility of improving lodging resistance independent of plant height. Using 50k iSelect SNP genotyping data, we conducted multi-environment genome-wide association studies using mixed model approach across the whole panel and row-type subsets: we identified a total of 192 quantitative trait loci (QTLs) for the studied traits, including subpopulation-specific QTLs and 21 main effect loci for culm diameter and/or section modulus showing effects on lodging without impacting plant height. Providing insights into the genetic architecture of culm morphology in barley and the possible role of candidate genes involved in hormone and cell wall–related pathways, this work supports the potential of loci underpinning culm features to improve lodging resistance and increase barley yield stability under changing environments.
Warming-induced drought leads to tree growth decline in subtropics: Evidence from tree rings in central China
Authors: Jing Mengdan , Zhu Liangjun , Liu Shuguang , Cao Yang , Zhu Yu , Yan Wende
Published: September 2022

Subtropical forests provide diverse ecosystem services to human society. However, how subtropical tree species respond to climate change is still unclear. Using a dendrochronological method, we studied the radial growth patterns and species-specific responses of four main tree species in subtropical China to recent warming and drought. Results showed that the long-term drought caused by global warming and reduced precipitation since 1997 had resulted in the growth decline of Pinus massoniana, Castanea henryi and Castanopsis eyrei but not for Liquidambar formosana. Four species had similar sensitivities to the previous year and the current year, which is probably due to the carryover effect and temporal autocorrelation of climate data. Tree growth was positively correlated with growing season precipitation and relative humidity while negatively correlated with vapor pressure deficit. The negative relationship of tree radial growth with temperatures in the previous and current summer and the positive correlation with precipitation gradually strengthened after 1997. Therefore, we highlighted that drought-induced tree decline in subtropical forests is probably a common phenomenon, and it needed to verify by more tree-ring studies on a large scale. The species-specific responses of tree radial growth to climate change are not obvious, but they still should be considered in regional carbon balance and forest dynamics. Considering future climate change, species that are more drought tolerant should be considered as potential plantation species.
Full-length transcriptional analysis reveals the complex relationship of leaves and roots in responses to cold-drought combined stress in common vetch
Authors: Min Xueyang , Wang Qiuxia , Wei Zhenwu , Liu Zhipeng , Liu Wenxian
Published: September 2022

Plant responses to single or combined abiotic stresses between aboveground and underground parts are complex and require crosstalk signaling pathways. In this study, we explored the transcriptome data of common vetch (Vicia sativaL.) subjected to cold and drought stress between leaves and rootsviameta-analysis to identify the hub abiotic stress-responsive genes. A total of 4,836 and 3,103 differentially expressed genes (DEGs) were identified in the leaves and roots, respectively. Transcriptome analysis results showed that the set of stress-responsive DEGs to concurrent stress is distinct from single stress, indicating a specialized and unique response to combined stresses in common vetch. Gene Ontology (GO) enrichment analyses identified that “Photosystem II,” “Defence response,” and “Sucrose synthase/metabolic activity” were the most significantly enriched categories in leaves, roots, and both tissues, respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis results indicated that “ABC transporters” are the most enriched pathway and that all of the genes were upregulated in roots. Furthermore, 29 co-induced DEGs were identified as hub genes based on the consensus expression profile module of single and co-occurrence stress analysis. In transgenic yeast, the overexpression of three cross-stress tolerance candidate genes increased yeast tolerance to cold-drought combined stress. The elucidation of the combined stress-responsive network in common vetch to better parse the complex regulation of abiotic responses in plants facilitates more adequate legume forage breeding for combined stress tolerance.
Holocene landscape evolution and its interaction with human activities in the southern piedmont of Taihang Mountain, Central China
Authors: Zhang Xiaohu , Yang Shugang , Lu Peng , Li Yaping , Chen Panpan , Xia Zhengkai
Published: September 2022

Piedmont zones have been witnessing intensive human activities since ancient times. However, it remains unclear when it comes to the environmental mechanism for early humans exploiting piedmont zones. Here we present a case study about the interactions between early human activities and landscape evolution in the piedmont of Taihang Mountain, an area with prominent ecological and cultural significance in Chinese history. Based on chronological and pollen analyses, we reconstruct the regional landscape evolution in the Fengtougang (FTG) site of southern Taihang Mountain during the Holocene. The results show that the area has been dominated by terrestrial plants since the late Longshan culture (4000 BP), including a large number of Pinus, Artemisia, Spiraea, and Gramineae, a few Cattails, and some other aquatic herbs. During the early history (4000-2000 BP), there is a combination of Pinus, Artemisia, Spiraea, Compositae, and Selaginella Chinensis, with a few aquatic plants. Since the late history (500 BP), the Chinese selaginella, Pinus, Selaginella, and Sedge families dominate, with no aquatic plant pollen found. Combining the detailed geoarchaeological survey, grain size analysis, and magnetic susceptibility analysis, we demonstrate that there should be a landscape of extensive floodplain during the early-middle Holocene (10000-4000 BP). During the late Longshan culture (about 4000 BP), the study area should be dominated by a landscape of sparse forest grassland with interlacing rivers and lakes. With river downcutting and watercourse fixation since the late Longshan culture, the flooded area massively shrinks, providing suitable habitat for human settlement. From then on, human activities begin to move to the study area on a large scale, followed by continuous cultural development and thriving early civilization.
Functional peptide-mediated plastid transformation in tobacco, rice, and kenaf
Authors: Odahara Masaki , Horii Yoko , Itami Jun , Watanabe Kenta , Numata Keiji
Published: September 2022

In plant engineering, plastid transformation is more advantageous than nuclear transformation because it results in high levels of protein expression from multiple genome copies per cell and is unaffected by gene silencing. The common plastid transformation methods are biolistic bombardment that requires special instruments and PEG-mediated transformation that is only applicable to protoplast cells. Here, we aimed to establish a new plastid transformation method in tobacco, rice, and kenaf using a biocompatible fusion peptide as a carrier to deliver DNA into plastids. We used a fusion peptide, KH-AtOEP34, comprising a polycationic DNA-binding peptide (KH) and a plastid-targeting peptide (AtOEP34) to successfully deliver and integrate construct DNA into plastid DNA (ptDNA) via homologous recombination. We obtained transformants in each species using selection with spectinomycin/streptomycin and the corresponding resistance gene aadA. The constructs remained in ptDNA for several months after introduction even under non-selective condition. The transformants normally flowered and are fertile in most cases. The offspring of the transformants (the T1 generation) retained the integrated construct DNA in their ptDNA, as indicated by PCR and DNA blotting, and expressed GFP in plastids from the integrated construct DNA. In summary, we successfully used the fusion peptide method for integration of foreign DNA in tobacco, rice, and kenaf ptDNA, and the integrated DNA was transmitted to the next generations. Whereas optimization is necessary to obtain homoplasmic plastid transformants that enable stable heterologous expression of genes, the plastid transformation method shown here is a novel nanomaterial-based approach distinct from the conventional methods, and we propose that this easy method could be used to target a wide variety of plants.
Comparative transcriptome analysis reveals key pathways and genes involved in trichome development in tea plant (Camellia sinensis)
Authors: Chen Lan , Tian Na , Hu Mengqing , Sandhu Devinder , Jin Qifang , Gu Meiyi , Zhang Xiangqin , Peng Ying , Zhang Jiali , Chen Zhenyan , Liu Guizhi , Huang Mengdi , Huang Jianan , Liu Zhonghua , Liu Shuoqian
Published: September 2022

Trichomes, which develop from epidermal cells, are considered one of the important characteristics of the tea plant [Camellia sinensis (L.) O. Kuntze]. Many nutritional and metabolomic studies have indicated the important contributions of trichomes to tea products quality. However, understanding the regulation of trichome formation at the molecular level remains elusive in tea plants. Herein, we present a genome-wide comparative transcriptome analysis between the hairless Chuyeqi (CYQ) with fewer trichomes and the hairy Budiaomao (BDM) with more trichomes tea plant genotypes, toward the identification of biological processes and functional gene activities that occur during trichome development. In the present study, trichomes in both cultivars CYQ and BDM were unicellular, unbranched, straight, and soft-structured. The density of trichomes was the highest in the bud and tender leaf periods. Further, using the high-throughput sequencing method, we identified 48,856 unigenes, of which 31,574 were differentially expressed. In an analysis of 208 differentially expressed genes (DEGs) encoding transcription factors (TFs), five may involve in trichome development. In addition, on the basis of the Gene Ontology (GO) annotation and the weighted gene co-expression network analysis (WGCNA) results, we screened several DEGs that may contribute to trichome growth, including 66 DEGs related to plant resistance genes (PRGs), 172 DEGs related to cell wall biosynthesis pathway, 29 DEGs related to cell cycle pathway, and 45 DEGs related to cytoskeleton biosynthesis. Collectively, this study provided high-quality RNA-seq information to improve our understanding of the molecular regulatory mechanism of trichome development and lay a foundation for additional trichome studies in tea plants.
Word complexity modulates the divided-word effect during Chinese reading
Authors: Zhang Mingzhe , Bai Xuejun , Li Sainan
Published: September 2022

The present study examined the influence of word complexity on the divided-word effect. By manipulating presentation conditions (line-final presentation vs. divided-word presentation vs. line-initial presentation) and visual complexity (high vs. low), we found a significant divided-word effect that the reading times such as gaze duration and total reading time were significantly longer in the divided-word presentation condition than in both the line-final and line-initial presentation conditions. On the measure of total reading time, the marginally significant interaction between the divided-word versus line-final presentation comparison and complexity showed that the divided-word effect was larger for low complexity words than that for high complexity words. These results suggest that dividing a word across two lines interferes with reading, and word complexity modulates this effect.
Occupation-specific recruitment: An empirical investigation on job seekers’ occupational (non-)fit, employer image, and employer attractiveness
Authors: Gilch Phyllis Messalina
Published: September 2022

Organizations may need to attract occupational groups they did not recruit so far to implement strategic changes (e.g., digital transformation). Against the backdrop of this practical problem, this study introduces and explores an occupation-based measure of person-organization fit: occupational fit. I investigate its relationship with employer attractiveness based on human capital theory and explore the role of employer image as a moderator in this relationship. I surveyed 153 software engineers and mechanical engineers to analyze whether their occupational fit with software engineering and mechanical engineering firms is related to employer attractiveness. I find that occupational fit is only related to a firm’s employer attractiveness among software engineers. Employer image does not moderate this relationship. A qualitative follow-up study proposes first explanations for the unexpected differences between the two occupations by indicating that occupations may differ in the logic they apply to determine fit and their degree of professionalization. The study contributes to research by highlighting the neglected role of occupation in recruitment research and exploring potential boundary conditions of recruitment for fit. Implications for future research and practice are discussed.
The dark side of university student entrepreneurship: Exploration of Chinese universities
Authors: Wang Xuyan , Chen Fan , Ni Hao
Published: September 2022

The dark side of entrepreneurship, especially the dark side of student entrepreneurship, has received little attention from academia. This study tries to examine the dark side of entrepreneurship among students in Chinese universities. Employing qualitative method by conducting semi-structured interview with students at the universities. Our study identifies the unproductive and destructive factors that drive the dark side of student entrepreneurship. Entrepreneurship costs that accompany students in the process of entrepreneurship are usually time pressure, academic conflict, and even health damage. There is a huge discrepancy between the knowledge given to students by universities and the knowledge required for entrepreneurship, and college students frequently lack entrepreneurial knowledge and business logic. In China, the use of inappropriate policy tools has decoupled the student entrepreneurship policies it pursues from the purpose the policies are supposed to serve. In so doing, this study contributes to the micro-level of the notion of the dark side of student entrepreneurship.
Investigating the relationship between online information seeking and translation performance among translation students: The mediating role of translation self-efficacy
Authors: Lu Sha , Xiangling Wang , Shuya Ma
Published: September 2022

The widespread use of online information resources by translation students has motivated an increasing number of researchers to investigate the relationship between online information seeking and translation performance. However, these studies mainly address the direct effect of online information seeking on translation performance, thus failing to explore and identify the internal psychological mechanisms. This study, therefore, explores the mediating role of translation self-efficacy in the relationship between online information seeking and translation performance. A total of 314 translation students in China completed questionnaires on online information seeking and translation self-efficacy, and translation performance was measured by assessing the quality of a translation task given to them. Results showed that translation self-efficacy partially mediated the association between online information seeking and students’ translation performance. These findings can contribute to our understanding of the role that translation self-efficacy plays in information seeking behaviors and the emotional states of translation students in translator training.
Parental tuning of language input to autistic and nonspectrum children
Authors: He Angela Xiaoxue , Luyster Rhiannon J. , Arunachalam Sudha
Published: September 2022

Caregivers’ language input supports children’s language development, and it is often tuned to the child’s current level of skill. Evidence suggests that parental input is tuned to accommodate children’s expressive language levels, but accommodation to receptive language abilities is less understood. In particular, little is known about parental sensitivity to children’s abilities to process language in real time. Compared to nonspectrum children, children on the spectrum are slower to process language. In this study, we ask: Do parents of autistic children and those of nonspectrum children tune their language input to accommodate children’s different language processing abilities? Children with and without a diagnosis of autism (ages 2–6 years, N = 35) and their parents viewed a display of six images, one of which was the target. The parent labeled the target to direct the child’s attention to it. We first examined children’s language processing abilities by assessing their latencies to shift gaze to the labeled referent; from this, we found slower latencies in the autistic group than in the nonspectrum group, in line with previous findings. We then examined features of parents’ language and found that parents in both groups produced similar language, suggesting that parents may not adjust their language input according to children’s speed of language processing. This finding suggests that (1) capturing parental sensitivity to children’s receptive language, and specifically language processing, may enrich our models of individual differences in language input, and (2) future work should investigate if supporting caregivers in tuning their language use according to children’s language processing can improve children’s language outcomes.
Why is reusable bag consumption easier to say than do?
Authors: Yan Dongqing , Cai Xiang , Xie Meiying , Javeed Sohail Ahmad , Liu Fengqin , Cao Qun
Published: September 2022

White pollution has become a global problem. China issued a strict plastic ban but fell into an awkward position. Despite the increasing environmental awareness, the positive attitude of consumers toward using reusable bags instead of plastic bags is difficult to reflect on from their behavior. This article bridges this gap by utilizing a consumer behavior framework based on the behavioral reasoning theory (BRT) and the attitude-behavior-context (ABC) model. This framework is tested using structural equation modeling with 481 Chinese consumers. This article confirms that the value has a significant impact on consumer attitudes. Meanwhile, the article reveals the positive influence of “reasons for” in predicting attitudes and the negative influence of “reasons against” in predicting intentions. Reusable bag consumption behavior is a result of multiple pathways working together, which causes the gap between attitudes and behaviors. This article also confirms the moderating role of the Chinese face and the enforcement of the plastic ban in influencing behavior. These findings offer interesting insights for enterprises and governments to solve the problem of plastic consumption.
RETRACTED: Analysis of psychological characteristics and emotional expression based on deep learning in higher vocational music education
Authors: Liu Xin
Published: September 2022

Sentiment analysis is one of the important tasks of online opinion analysis and an important means to guide the direction of online opinion and maintain social stability. Due to the multiple characteristics of linguistic expressions, ambiguity, multiple meanings of words, and the increasing speed of new words, it is a great challenge for the task of text sentiment analysis. Commonly used machine learning methods suffer from inadequate text feature extraction, and the emergence of deep learning has brought a turnaround for this purpose. In this paper, we investigate the problem of text sentiment analysis using methods related to deep learning. In order to incorporate user and product information in a more diverse way in the model, this paper proposes a model based on a deep bidirectional long-and short-term memory network-self-attention mechanism-custom classifier. The model first identifies contextual associations and acquires deep text features through a deep bidirectional long- and short-term memory network and then captures important features in the text using a self-attentive mechanism. The model finally combines user information and product information to build a custom classifier module and uses context-aware attention mechanisms to assign specific parameters to user information and product information, which improves the performance of the model on public datasets compared with current common models. The results show that the accuracy of the algorithm in this paper is high, and it is about 5% lower than the traditional algorithm. The method can reduce the number of iterations and the running time of the algorithm.
Associations between two conceptualizations of materialism and subjective wellbeing in China: A meta-analysis of studies from 1998 to 2022
Authors: Zhou Kaiji , Lu Lin , Hu Liqun , Wang Yingzhao
Published: September 2022

This meta-analysis examines the relationship between materialism (materialistic values and extrinsic aspirations) and subjective wellbeing in the Chinese population. Fifty-six relevant studies covering the period from 1998 to 2022 were included in the meta-analysis. Fifty-eight independent effect sizes from a total of 52,368 participants were obtained to calculate the mean effect sizes. Materialistic values correlated with significantly lower subjective wellbeing (r = −0.205), while the mean effect size for extrinsic aspirations was found to be not significant (r = −0.048). The effect sizes varied across different types of wellbeing outcomes (materialistic values: rs = −0.095 to −0.202; extrinsic aspirations: rs = 0.066 to −0.125). The associations were also moderated by certain demographic factors (age and gender), methodological factors (study design and scoring method), publication features (type of publication and publication year), and economic indicators (economic growth and wealth inequality). We discuss our limitations and the implications for future research.
Fear-focused Self-compassion Therapy for young breast cancer patients' fear of cancer recurrence: Study protocol of a randomized controlled trial
Authors: Wei Liuyu , Yang Xiaomin , Sun Shasha , Yu Yunlei , Xie Juan , Zhao Jiang , Wang Xiao , Zhu Lei , Yao Juntao
Published: September 2022

Background

In China, there are a growing number of young women being diagnosed with breast cancer. Fear of Cancer Recurrence (FCR) has become one of the major psychological concerns reported by young breast cancer patients. Yet, there is a lack of psychological intervention tailored for reducing FCR for Chinese young breast cancer patients. In the current study, the Fear-focused Self-compassion Therapy is developed to help Chinese young breast cancer patients to manage FCR. The therapy was developed based on FCR development theories and self-compassion related therapy. The primary objective is to evaluate the short-term and long-term effectiveness of Fear-focused Self-compassion Therapy. The secondary objective is to examine the underlying mechanisms of therapy in reducing FCR in young breast cancer patients.

Methods

The Fear-focused Self-compassion Therapy consists of 8-week face to face group sessions. This study will be a randomized controlled trial with 160 Chinese young female breast cancer patients with severe FCR. Participants will be randomized to the therapy group or a usual care control group (1:1). Measurements will be completed at baseline, immediately completing intervention, 3, 6, and 12 months later. Primary outcomes are FCR severity, and secondary outcomes include symptoms of depression and anxiety, satisfaction with therapy, and cost-effectiveness of the therapy.

Discussion

If successful, this study will provide an effective psychological intervention to treat FCR for young breast cancer patients in China, and illuminate the underlying mechanisms of the Fear-focused Self-compassion Therapy in reducing FCR.

Clinical trial registration

ClinicalTrials.gov: NCT04965428. Registered 23rd July 2021, https://clinicaltrials.gov/ct2/show/NCT04965428?cond=fear+of+cancer+recurrence&draw=2&rank=1
Self-exclusion from gambling: A toothless tiger?
Authors: Kraus Ludwig , Loy Johanna K. , Bickl Andreas M. , Schwarzkopf Larissa , Volberg Rachel A. , Rolando Sara , Kankainen Veera E. , Hellman Matilda , Rossow Ingeborg , Room Robin , Norman Thomas , Cisneros Örnberg Jenny
Published: September 2022

While there is evidence for self-exclusion (SE) as an individual-level harm reduction intervention, its effects on reducing harm from gambling at the population level remain unclear. Based on a review of national legal frameworks and SE programs, including their utilization and enforcement in selected high-income societies, the present analysis aims to explore the reach and strengths of SE in the protection of gamblers in these jurisdictions. It places particular emphasis on SE programs' potential to prevent and minimize gambling harm at the population level. The overview examined SE in Finland, Germany, Italy, Massachusetts (USA), Norway, Sweden, and Victoria (Australia). These jurisdictions differ considerably in how gambling is regulated as well as in how SE is implemented and enforced. The reach and extent of enforcement of SE apparently vary with the polity's general policy balance between reducing gambling problems and increasing gambling revenue. But in any case, though SE may benefit individual gamblers and those around them, it does not appear to be capable of significantly reducing gambling harm at the population level. To render SE programs an effective measure that prevents gamblers and those linked to them from financial, social, and psychological harm, utilization needs to be substantially increased by reforming legal regulations and exclusion conditions.
The impact of COVID-19 safety interventions on creating a controlled environment on campus
Authors: Mahmood Sana , Ijaz Haider Sonia , Shahbaz Hamna , Noorali Ali Aahil , Afzal Noreen , Jiwani Aziz , Zaki Samar , Iqbal Khan Unab , Ajani Khairulnissa , Tariq Muhammad , Karmaliani Rozina , Haider Adil Hussain
Published: September 2022

Objectives

During COVID-19 the re-opening of educational institutes was frequently debated, however with the decline in the number of COVID-19 cases, The Aga Khan University (AKU) in Karachi, Pakistan opened its campus for medical and nursing students after more than 6 months of closure. To ensure gradual resumption of activities on-campus, a combination of interventions was diligently deployed to minimize student infection rates. Scarce literature exists on students' perceptions regarding decisions implemented by university leadership. The aim of the study was to determine the efficacy of these interventions.

Methods

We conducted a convergent, parallel, mixed-methods observational study targeting medical and nursing students. An online questionnaire was disseminated to elicit students' degree of (dis)agreement on a four-point Likert scale. Focused group discussions (FGDs) were conducted to comprehend reasons for (dis)agreement.

Results

Total of 183 students responded to questionnaire (59.0% nursing, 67.8% female), 11 FGDs were conducted with 85 students. Interventions with highest agreement were mandatory face masks policy (94.54%), weekly mandated COVID-testing (92.35%) and students' Academic Bubble (91.26%); highest disagreement was for Sehat Check application (41.53%); and stay strong campaign (40.44%). Four themes emerged from FGDs: Effective safety interventions, Safety interventions with limited effectiveness, Utility of Sehat Check Application and Future recommendations for informing policy.

Conclusion

It is paramount to seek student-feedback at forefront of university re-opening strategy. Clear communication channels are as important as an administrative response system's robustness. Bidirectional communication channels are fundamental and requisite during ever-changing policies and regulations. Engaging student representatives in decision making or implementation processes (such as “pilot” before “roll-out”) would allow any potential issues to be managed early on. Gather real-time anonymous feedback and identify key areas that need further promulgation and those that need to be replaced with more effective ones.
Building trusting relationships to support implementation: A proposed theoretical model
Authors: Metz Allison , Jensen Todd , Farley Amanda , Boaz Annette , Bartley Leah , Villodas Melissa
Published: September 2022

This paper presents a theory of change that articulates (a) proposed strategies for building trust among implementation stakeholders and (b) the theoretical linkages between trusting relationships and implementation outcomes. The theory of change describes how trusting relationships cultivate increases in motivation, capability, and opportunity for supporting implementation among implementation stakeholders, with implications for commitment and resilience for sustained implementation, and ultimately, positive implementation outcomes. Recommendations related to the measurement of key constructs in the theory of change are provided. The paper highlights how the development of a testable causal model on trusting relationships and implementation outcomes can provide a bridge between implementation research and implementation practice.
A predictive model of bowel resection for incarcerated inguinal hernia based on the systemic immune-inflammation index
Authors: Chen Lei , Chen Lei , Wang Ying-ying , Zhang Li-xiang , Xia Xiao-gang
Published: September 2022

Background and Purpose

An inguinal hernia is a common surgical disease. Once incarcerated or strangulated, it may endanger the life of the patient. Therefore, it is essential to study the risk factors of incarcerated inguinal hernia (IIH) and strangulated inguinal hernia (SIH). One of the serious complications of IIH and SIH is intestinal necrosis, which occurs owing to blood supply disorder. The study explores the risk factors of intestinal resection and establishes a simple model to assess the incidence of intestinal resection to provide significant assistance and limited guidance for clinical work.

Patients and Methods

Our research team collected and retrospectively analysed the clinical data of 338 patients with IIH who were hospitalized in the First Affiliated Hospital of Wenzhou Medical University between September 2008 and December 2016. According to the surgical plan, we divided the included cases into two groups, non-intestinal and intestinal resection groups, and the clinical case characteristics of these groups were statistically analysed.

Results

Based on multivariable logistic regression analysis, we found that increased risk of bowel resection was highly correlated among the elderly (≥70 years), and for people with high temperature (≥37.3°C), high systemic immune-inflammation index(SII) values (≥1230.13), presence of bowel obstruction, and signs of peritonitis. Further, we processed the five independent risk factors using special software to obtain a simple model called a nomogram. To verify the nomogram’s accuracy and predictive ability, we calculate the C-index: 0.806 and use the calibration curve to evaluate its stability and predictive performance. We constructed the ROC curve nomogram and other sub-variables, and calculated the area under the curve (AUC) corresponding to the nomogram (AUC = 0.808, 95% CI = 0.762 to 0.848), SII (AUC = 0.752, 95% CI = 0.703 to 0.797), age (AUC = 0.641, 95% CI = 0.587 to 0.692), temperature (AUC = 0.579, 95% CI = 0.524 to 0.632), bowel obstruction (AUC = 0.685, 95% CI = 0.633 to 0.734), and signs of peritonitis (AUC = 0.580, 95% CI = 0.525 to 0.633).

Conclusion

It can be said that we found for the first time that clinical variables such as SII are independent risk factors for enterectomy for IIH. The nomogram based on SII and other variables can accurately and easily predict the probability of IIH requiring bowel resection.
Dietary Fiber Supplementation in Replacement Gilts Improves the Reproductive Performance From the Second to Fifth Parities
Authors: Zhuo Yong , Hua Lun , Che Lianqiang , Fang Zhengfeng , Lin Yan , Xu Shengyu , Wang Jianping , Li Jian , Feng Bin , Wu De
Published: September 2022

This study examined the effects of soluble fiber (SF) supplementation (0.8%), containing 17.4% rhamnose, 4.1% fucose, 11.1% arabinose, 30.6% xylose, and 16.4% galactose during the prepubescent phase on the subsequent performance from the second to fifth parities. After the first parity, 56 and 55 post-weaning sows in the control (CON) and SF groups had their reproductive performance monitored in succeeding parities. Circulating concentrations of anti-mullerian hormone (AMH) were greater in the SF group than in the CON group at 205 d of age and the first post-weaning day (p < 0.05). The SF treatment at the prepubescent phase resulted in an enhanced reproductive performance from parities three to five. In Parity three, the SF sows had 1.32 total born (p = 0.044), 1.43 born alive (p = 0.023) and 1.40 born effective, which was significantly more than in the CON group (p = 0.022). In Parity four, the SF sows had 1.1 total born (p = 0.058), 1.28 born alive (p = 0.019), and 1.06 born effective, significantly more than in the CON group (p = 0.049). In Parity five, the SF gilts had 1.43 total born (p = 0.075), 1.53 born alive (p = 0.067) and 1.65 born effective, significantly more than in the CON group (p = 0.020). No effects were observed for the removal of sows and backfat thickness at the mating in each parity between groups (p > 0.05). Collectively, gilts that received an extra 0.8% SF during the prepubescent phase increased their subsequent litter size as breeding sows. These results showed that nutritional decisions at the replacement phase could influence lifetime fertility.
Predicted cellular interactors of the endogenous retrovirus-K protease enzyme
Authors: Narvey Samuel , Vandenakker Alex , Rempel Megan , Douville Renée N.
Published: September 2022

Retroviral proteases are essential enzymes for viral replication and drive changes within the cellular proteome. While several studies have demonstrated that protease (PR) enzymes from exogenous retroviruses cleave cellular proteins and modulate cellular signaling, the impact of PRs encoded by endogenous retroviruses within the human genome has been largely overlooked. One human symbiont called Endogenous retrovirus-K (ERVK) is pathologically associated with both neurological disease and cancers. Using a computational biology approach, we sought to characterize the ERVK PR interactome. The ERVK PR protein sequence was analyzed using the Eukaryotic Linear Motif (ELM) database and results compared to ELMs of other betaretroviral PRs and similar endogenated viral PRs. A list of putative ERVK PR cellular protein interactors was curated from the ELM list and submitted for STRING analysis to generate an ERVK PR interactome. Reactome analysis was used to identify key pathways potentially influenced by ERVK PR. Network analysis postulated that ERVK PR interacts at the apex of several ubiquitination pathways, as well as has a role in the DNA damage response, gene regulation, and intracellular trafficking. Among retroviral PRs, a predicted interaction with proliferating cell nuclear antigen (PCNA) was unique to ERVK PR. The most prominent disease-associated pathways identified were viral carcinogenesis and neurodegeneration. This strengthens the role of ERVK PR in these pathologies by putatively driving alterations in cellular signaling cascades via select protein-protein interactions.
How mHealth Can Contribute to Improving the Continuum of Care: A Scoping Review Approach to the Case of Human Immunodeficiency Virus in Sub-Saharan Africa
Authors: Lepere Philippe , Babington-Ashaye Awa , Martínez-Pérez Guillermo Z. , Ekouevi Didier Koumavi , Labrique Alain Bernard , Calmy Alexandra
Published: September 2022

Objectives: To determine mHealth’s contribution to improving the continuum of care in sub-Saharan Africa towards achieving treatment targets for human immunodeficiency virus (HIV) endorsed by the 2016 Political Declaration on ending acquired immunodeficiency syndrome (AIDS).

Methods: PubMed, Medline, Embase, Web of Science Core Collection and Cochrane databases; three observatories and four repositories were searched to identify and select relevant articles, projects and guidelines published from 1 January 2017, to 30 April 2021. Records focusing on the use of mHealth related to HIV treatment cascade or healthcare provider/patient relationship were considered.

Results: From 574 identified records, 381 (206 scientific manuscripts and 175 mHealth projects) were considered. After screening, 36 articles (nine randomized control trials, five cohort studies, 19 qualitative studies, and three economic studies) and 23 projects were included.

Conclusion: The cross-cutting benefits of mHealth that enhance patient empowerment have been identified. Important challenges such as gaps between research and implementation, lack of transdisciplinary collaboration, and lack of economic evidence were identified to support future mHealth research and accelerate the achievement of treatment targets for HIV.
The Human Capital Risk Reporting of Listed South African Companies: Exploring a Reporting Framework to Support Corporate Governance
Authors: Bruwer Monique , Scholtz Salomé Elizabeth , De Beer Leon Tielman , Rothmann Johanna Christina
Published: September 2022

Despite the importance and requirement of integrated reporting on human capital (HC), research indicates a lack of reporting frameworks and adequate disclosure in organization reports. Thus, a unique research opportunity is created for researchers to determine what is being presented in reports and how it correlates with human resource management. This article investigates HC reporting practices and proposes a risk reporting framework in support of corporate governance. A qualitative method utilizing qualitative document analysis was followed to analyze a purposive sample (n = 39) of Johannesburg Stock Exchange top 40 listed companies’ annual integrated reports of 2020. Overall, companies followed a widely accepted risk management approach, with inconsistencies in the phases and methods of reporting the risk management phases directed at HC. The magnitude of the risk to the companies is also not understood. The most commonly reported HC risks were employee growth and development, diversity and inclusion, career paths, and employee turnover and turnover intention. Employee work-related well-being was largely neglected. An interesting finding is that the reported risks were metrics-deprived. Current HC practices are backward-looking instead of forward-looking, and they are fragmented. Therefore, an HC reporting framework is suggested for future research that addresses the gaps in integrated reports.
Maternal Dietary Supplementation with γ-Aminobutyric Acid Alleviated Oxidative Stress in Gestating Sows and Their Offspring by Regulating GABRP
Authors: Liu Xiaoyi , Jiang Lili , Pang Jiaman , Wu Yujun , Pi Yu , Zang Jianjun , Wang Junjun , Han Dandan
Published: September 2022

Sows usually suffer oxidative stress during gestation, and this limits the growth of fetuses via placenta. Gamma-aminobutyric acid (GABA) is a functional nonessential amino acid engaged in regulating the physiological status of animals. However, the effects of GABA on the oxidative homeostasis of sows and their offspring remain unclear. Eighteen late gestating sows (85 d) were divided into the CON and GABA groups and fed the basal diet and the GABA diet (200 mg/kg GABA), respectively, until farrowing. At parturition, the sows’ litter characteristics, the plasma antioxidant parameters of sows, and their offspring were evaluated. The results showed that GABA supplementation had no marked effect on the reproductive performance of sows (p > 0.10) but had a trend of reducing the amount of intrauterine growth restriction (IUGR) in piglets (0.05 < p < 0.10). At the same time, the addition of GABA elevated the plasma superoxide dismutase (SOD) level of sows and enhanced the glutathione peroxidase (GSH-Px) activity of newborn piglets (p < 0.05). Based on the H2O2-induced oxidative stress in pTr-2 cells, GABA elevated intracellular GSH-Px, SOD, catalase (CAT), and total antioxidant capacity (T-AOC, p < 0.01) and upregulated the gene expressions of CAT, gamma-aminobutyric acid receptor (GABRP), and nuclear factor-erythroid 2-related factor-2 (Nrf2) in H2O2-treated pTr-2 cells (p < 0.05). Taken together, GABA improved the antioxidant capacity of sows and alleviated the placental oxidative stress by upregulating the GABRP and Nrf2 genes, which have the potential to promote oxidative homeostasis in newborn piglets.
Hemp in Animal Diets—Cannabidiol
Authors: Fallahi Sepideh , Bobak Łukasz , Opaliński Sebastian
Published: September 2022

In recent years, interest in hemp use has grown owing to its chemical and medicinal properties. Several parts of this plant, such as seeds, leaves, flowers, and stems are used in medicine, industry, and environmental preservation. Although there were legal restrictions on hemp exploitation in some countries due to the trace presence of THC as a psychoactive element, many countries have legalized it in recent years. Cannabidiol or CBD is a non-psychoactive phytocannabinoid that can activate the endocannabinoid system and its receptors in the central and peripheral nervous system in bodies of different species. Cannabidiol has anti-inflammatory, antioxidative, analgesic, and anti-depressant effects. This review investigates various aspects of cannabidiol use and its potential in animals and humans.