bluuebunny/crossref_metadata_2025 huggingface dataset:
Robust 3D Graphene/Cellulose Nanocrystals Hybrid Lamella Network for Stable and Highly Efficient Solar Desalination
Authors: Li Haoxiang , Jia Dedong , Ding Meichun , Zhou Lijuan , Wang Kai , Liu Jingquan , Liu Chen-Yang , Li Chenwei
Published: June 2021

Solar‐driven vapor generation is one of the most promising techniques for seawater desalination, which has attracted broad attention. However, a significant challenge remains for achieving a low‐cost and easy‐to‐manufacture solar‐driven steam generation device with higher evaporation efficiency, excellent mechanical performance, and good durability. Herein, a simple and cost‐effective method is developed to prepare graphene/cellulose nanocrystals (CNCs) lamella network (GCLN) with melamine foam (MF) as the skeleton. Due to the excellent light absorption properties of graphene and excellent hydrophilic properties of CNCs, GCLN exhibits an evaporation rate of 1.66 kg m−2 h−1 and an evaporation efficiency of 97.5% under 1 kW m−2 of solar radiation. In addition, GCLN can maintain its structural stability and evaporation performance during a series of harsh condition and durability tests. Due to the excellent processability of MF, the 3D‐shaped GCLN can be easily designed for an enhanced evaporation rate of 1.59 kg m−2 h−1, which is better than the theoretical limit of the evaporation rate. The novel design presented in this work offers a new avenue to develop solar steam generation devices for low‐cost and large‐scale seawater desalination under natural sunlight conditions, which is especially attractive for the urgent fresh water supply in remote areas.
Recent progress on precious metal single atom materials for water splitting catalysis
Authors: Zhou Lei , Lu Shi‐Yu , Guo Shaojun
Published: June 2021

Electrochemical water splitting for hydrogen production has sparked intensive interests because it provides a new approach for sustainable energy resources and the avoidance of environmental problems. The precious metal‐based single atomic catalysts (PMSACs) have been widely employed in water splitting catalysis by virtue of their maximum atom utilization and unique electronic structure, which can reduce metal amounts and remain high catalytic performance simultaneously. In this review, we will summarize recent research efforts toward developing SACs based on precious metals with excellent performance for electrochemical water splitting catalysis. First, the synthesis strategies for PMSACs will be classified and introduced including high‐temperature pyrolysis, electrochemical method, photochemical reduction, wet chemistry method, etc. Then, a short description of characterization techniques for SACs will be given, which mainly involves the aberration‐corrected scanning‐transmission electron microscopy (AC‐STEM) and X‐ray absorption spectroscopy (XAS). In particular, the relationship between the electronic structure of the precious metal atomic sites and performance for water splitting will be discussed according to the theoretical and experimental results. Finally, a brief perspective will be provided to highlight the challenges and opportunities for the development of novel PMSACs suitable for electrochemical water splitting applications.
Introduction and Overview
Authors: Kern Margaret L. , Wehmeyer Michael L.
Published: June 2021

Over the past decade, the positive education movement has grown, with the rapid increase of research, curricula, programs, and approaches to supporting wellbeing within educational communities. We introduce positive education, unpacking the positive perspective, considering how positive education emerged from this perspective, and discussing the implications moving forward. We then provide an overview of the chapters within this Handbook. Aligned with the valuing of open dialogue and diverse perspectives, authors provide various definitions of, perspectives around, and approaches to positive education. The Handbook attempts to give light to the plurality of models and perspectives, highlights high-quality research and research-to-practice efforts, incorporates a broad range of topics, and includes international and multi-disciplinary approaches. As a whole, the Handbook aims to support collective efforts to create and shape educational environments that allow all members of our educational communities to thrive, both now and for future generations.
Assessing Wellbeing in School Communities
Authors: Jarden Aaron , Jarden Rebecca , Chin Tan-Chyuan , Kern Margaret L.
Published: June 2021

This chapter summarizes the essentials of assessment, principles of good assessment, and wellbeing assessment in the context of school communities. Drawing from positive education initiatives, what wellbeing assessments in schools look like, and why they are important is outlined and discussed. Examples of good assessment tools and their use in practice are explored. The chapter further focuses on the content, processes, and systems involved in assessment, before addressing the use of assessment data in decision-making and providing examples of good assessment in practice. The chapter ends by highlighting questions schools and decision-makers may draw from in choosing and developing assessment tools and approaches for their unique school community.
Building Positive Emotions and Playfulness
Authors: Tidmand Louise
Published: June 2021

This chapter focuses on the What? Why? and How? of building positive emotions and playfulness. What are positive emotions and playfulness? Why are these concepts part of the foundation of positive education? And How may we build positive emotions and playfulness in our pedagogical practice. In the profession of teaching, positive emotions and playfulness are closely linked to the development of coping skills and strategies, social competencies, cognitive competencies, and learning, as well as to the VIA character strengths. The chapter gives examples and suggestions as to how positive emotions and playfulness may be implemented in the three phases of teaching: preparation and lesson planning, pedagogical practice in the classroom, and evaluation of the lesson. The chapter furthermore looks into how positive emotions and playfulness are part of and contribute to the positive educational framework, to both student and staff wellbeing in the classroom, and as well as in the learning institution as a workplace.
Positive Spirituality
Authors: McCall Theo D.
Published: June 2021

Positive spirituality is about acknowledging the personal spiritual growth that can occur through the use of some techniques from positive psychology. Contemporary educational philosophy within secular government educational departments rarely, if ever, addresses the notion of a spiritual life within educational institutions. Religious schools, on the other hand, usually include prayer and spirituality at the foundation of their educational aims. There is a clear disconnection between the two systems in this respect. Positive spirituality potentially provides a bridge between these two systems, bringing a focus on a broad notion of spirituality to otherwise secular government/public systems, and scientifically validated approaches to potentially narrowly focused religious schools. For instance, meditative techniques, relaxation, and physical stillness can help bring spiritual awareness to the fore, and in the process highlight a connection to something larger than oneself—the very goal of all mystics and a noble educational objective as teachers strive to inspire a greater sense of meaning and purpose in their students.
Mindfulness in Education: Insights Towards an Integrative Paradigm
Authors: Sheinman Nimrod , Russo-Netzer Pninit
Published: June 2021

This chapter reviews mindfulness in education and presents its role in the context of holistic well-being and a whole-child approach. We discuss the diverse initiatives and pedagogies of mindfulness in education around the world and present their potential contributions to students and teachers. Research outcomes, empirical findings, and synergy with positive education are examined.
Conclusion
Authors: Kern Margaret L. , Wehmeyer Michael L.
Published: June 2021

The chapters in this Handbook provide evidence of the plurality of theories, models, methods, and perspectives relevant to positive education. Chapters highlight the diverse ways in which positive education is conceptualized and implemented, complexities inherent to school environments, and the need to rigorously study the impact of activities. Chapters describe core ingredients of positive education, including basic psychological needs, mindset, character strengths, coping skills, empathy, engagement, gratitude, social relationships, emotions, kindness, meaning and purpose, mindfulness, self-efficacy, self-regulation, and wellbeing literacy. These ingredients primarily emphasize the skills and attributes of the person. Yet other chapters remind us of the importance of the social and environmental context, including the impact that trauma, disadvantage, culture, socioeconomic pressures, and broader systemic pressures have. Together, the chapters speak to both the possibilities and challenges of what positive education might become.
First saturation correction in high energy proton-nucleus collisions. Part I. Time evolution of classical Yang-Mills fields beyond leading order
Authors: Li Ming , Skokov Vladimir V.
Published: June 2021

Abstract

In high energy proton-nucleus collisions, the single- and double-inclusive soft gluon productions at the leading order have been calculated and phenomenologically studied in various approaches for many years. These studies do not take into account the saturation and multiple rescatterings in the field of the proton. The first saturation correction to these leading order results (the terms that are enhanced by the combination$$ {\alpha}_s^2{\mu}^2 $$αs2μ2, whereμ2is the proton’s color charge squared per unit transverse area) has not been completely derived despite recent attempts using a diagrammatic approach. This paper is the first in a series of papers towards analytically completing the first saturation correction to physical observables in high energy proton-nucleus collisions. Our approach is to analytically solve the classical Yang-Mills equations in the dilute-dense regime using the Color Glass Condensate effective theory and compute physical observables constructed from classical gluon fields. In the current paper, the Yang-Mills equations are solved perturbatively in the field of the dilute object (the proton). Next-to-leading order and next-to-next-to-leading order analytic solutions are explicitly constructed. A systematic way to obtain all higher order analytic solutions is outlined.
Drive axis controller optimization of production machines based on dynamic models
Authors: Halamka Vojtěch , Moravec Jan , Beneš Petr , Neusser Zdeněk , Koubek Jan , Kozlok Tomáš , Valášek Michael , Šika Zbyněk
Published: June 2021

The paper deals with the creation and implementation of a methodology for optimizing the parameters of cascade control of the machine tool axis drives. The first part presents the identification of a dynamic model of the axis based on experimental data from measuring the axis dynamics. The second part describes the controller model, selection of optimization objective functions, and optimization of constraint conditions. The optimization of controllers is tuned by simulation using identified state-space model. Subsequently, the optimization procedure is implemented on the identified model, and the found control parameters are used on a real machine tool linear axis with different loads. The implementation of the proposed complex procedure on a real horizontal machine tool proved the advantage of simultaneous tuning of all parameters using optimization methods. The strategy solves the problem of mutual interaction of all control law parameters disabling effective usability of gradual sequential tuning. The methodology was developed on a speed control loop, the tuning of which is usually the most difficult due to the close interaction with the dynamic properties of the machine mechanics. The whole procedure is also applicable to the position and current control loop.
In situ measurement and closed-loop control for powder supply processes
Authors: Breese Philipp Peter , Hauser Tobias , Regulin Daniel , Seebauer Stefan , Rupprecht Christian
Published: June 2021

The powder mass flow rate is one of the main parameters regarding the geometrical precision of built components in the additive manufacturing process of laser metal deposition. However, its accuracy, constancy, and repeatability over the course of the running process is not given. Reasons among others are the performance of the powder conveyors, the complex nature of the powder behavior, and the resulting issues with existing closed-loop control approaches. Additionally, a direct in situ measurement of the powder mass flow rate is only possible with intrusive methods. This publication introduces a novel approach to measure the current powder mass flow rate at a frequency of 125 Hz. The volumetric powder flow evaluation given by a simple optical sensor concept was transferred to a mass flow rate through mathematical dependencies. They were found experimentally for a nickel-based powder (Inconel 625) and are valid for a wide range of mass flow rates. With this, the dynamic behavior of a vibration powder feeder was investigated and a memory effect dependent on previous powder feeder speeds was discovered. Next, a closed-loop control with the received sensor signal was implemented. The concept as a whole gives a repeatable and accurate powder mass flow rate while being universally retrofittable and applicable. In a final step, the improved dynamic and steady performance of the powder mass flow rate with closed-loop control was validated. It showed a reduction of mean relative errors for step responses of up to 81% compared to the uncontrolled cases.
Current situation of complications related to reconstructive surgery for pelvic organ prolapse: a multicenter study
Authors: Sun Zhi-jing , Guo Tao , Wang Xiu-qi , Lang Jing-he , Xu Tao , Zhu Lan
Published: June 2021

Introduction and hypothesis

This study aimed to investigate the evaluation and management of complications after pelvic floor reconstructive surgery for pelvic organ prolapse in China.

Methods

Complications of pelvic floor reconstructive surgery for pelvic organ prolapses from 27 institutions were reported from November 2017 to October 2019. All complications were coded according to the category-time-site system proposed by the International Urogynecological Association (IUGA) and the International Continence Society (ICS). The severity of the complications was graded by the Clavien-Dindo grading system. Four scales were used to evaluate patient satisfaction and quality of life after management of the complications: the Patient Global Impression of Improvement (PGI-I), the Pelvic Floor Impact Questionnaire Short Form (PFIQ-7), the Pelvic Organ Prolapse Symptom Score (POP-SS), and a 5-point Likert-type scale that evaluated the patient’s choice of surgery.

Results

Totally, 256 cases were reported. The occurrence of complications related to transvaginal mesh (TVM) and laparoscopic sacrocolpopexy (LSC) had a significantly longer post-surgery delay than those of native tissue repair surgery (p < 0.001 and p = 0.010, respectively). Both PFIQ-7 and POP-SS score were lower after management of complications (p < 0.001). Most respondents (81.67%) selected very much better, much better, or a little better on the PGI-I scale. Only 13.3% respondents selected unlikely or highly unlikely on the 5-point Likert-type scale.

Conclusions

The occurrence of complications related to TVM surgery and LSC had a longer post-surgery delay than native tissue repair surgery. Long-term regular follow-up was vital in complication management. Patient satisfaction with the management of TVM complications was acceptable.
Revisiting the JOQUER trial: stratification of primary Sjögren’s syndrome and the clinical and interferon response to hydroxychloroquine
Authors: Collins Alexis , Lendrem Dennis , Wason James , Tarn Jessica , Howard-Tripp Nadia , Bodewes Iris , Versnel Marjan A. , Gottenberg Jacques-Eric , Seror Raphaele , Mariette Xavier , Ng Wan-Fai
Published: June 2021

To re-analyse the clinical outcomes and interferon (IFN) activity data from the JOQUER trial, a phase III trial investigating hydroxychloroquine (HCQ) in patients with primary Sjögren’s syndrome (pSS), after stratifying patients into putative pathobiological subgroups utilizing the Newcastle Sjögren’s Stratification Tool (NSST) based on patient-reported symptoms of dryness, pain, fatigue, anxiety and depression. 107 patients were assigned to one of four subgroups using NSST at baseline—the high symptom burden (HSB), pain dominant with fatigue (PDF), dryness dominant with fatigue (DDF) and low symptom burden (LSB). Endpoints were re-analysed after stratification, testing for treatment differences within subgroups and adjusting for baseline differences using a repeated measures covariate model. The HSB subgroup (n = 32) showed a relative improvement in ESSPRI of 1.49 points (95% CI 0.54–2.43;p = 0.002) within 12 weeks in patients taking HCQ compared to placebo, with no further changes after 24 weeks. For the LSB subgroup (n = 14), the ESSPRI worsened in the placebo but not the HCQ arm after 12 weeks (mean difference 1.44, 95% CI 0.05–2.83,p = 0.042). Neither the HSB nor the LSB patients showed significant changes in IFN activity at 24 weeks. There were no significant differences in ESSPRI in the PDF (n = 39) and DDF (n = 22) patients taking HCQ. However, significant reductions in overall IFN score at 24 weeks were seen in both PDF (difference at 24 weeks; 6.41, 95% CI, 2.48–10.34,p = 0.002) and DDF (difference at 24 weeks; 7.23, 95% CI, 1.85–12.6,p = 0.009) without improvement in ESSPRI. Although the JOQUER trial reported no overall benefit from HCQ in pSS patients, stratification suggests that both HSB and LSB subgroups may respond to HCQ. However, these patients may benefit through mechanisms other than the reduction of IFN activities.
Local, non-systemic, and minimally invasive therapies for calcinosis cutis: a systematic review
Authors: Nowaczyk Joanna , Zawistowski Michał , Fiedor Piotr
Published: June 2021

Calcinosis cutis is a deposition of calcium in the skin and subcutaneous tissue, often accompanied by pain, reduced mobility, and chronic infections. Limited evidence is available about the feasibility and efficacy of therapies alternative to systemic treatment and surgical excision, both of which often lead to unsatisfactory results or complications. We conducted a systematic review to evaluate the efficacy and safety of topical and intralesional sodium thiosulfate, extracorporeal shock-wave lithotripsy (ESWL), and laser for calcinosis cutis. PubMed, Embase, and Web of Science were searched. Reports of calciphylaxis and treatment combined with systemic medications were excluded. A total of 40 studies including 136 patients were analysed. Partial or complete remission after monotherapy was observed in 64% to 81% of cases. Self-applied topical sodium thiosulfate required patient’s adherence (mean treatment duration, 4.9 months; range 2–24). Laser therapy enabled complete remission of microcalcifications after a single procedure (57%; 12/21). ESWL and intralesional sodium thiosulfate injections decreased calcinosis-associated pain (median reduction in VAS score, 3; range 0–9 and 1; range 0–5, respectively). The most common adverse event was scarring and hyperkeratosis, observed after CO2 laser (56%; 10/18). Intralesional sodium thiosulfate injections caused transient pain in over 11% of patients. Recurrences within the follow-up were rare (2%; 3/136). This study provides an overview of minimally invasive and local therapies that in selected cases might transcend conventional treatment. The limitation of this study is the poor level of evidence, which emerges mainly from non-randomized studies at high risk of bias.
Initiation of antidepressants in young adults after ischemic stroke: a registry-based follow-up study
Authors: Broman Jenna , Aarnio Karoliina , But Anna , Marinkovic Ivan , Rodríguez-Pardo Jorge , Kaste Markku , Tatlisumak Turgut , Putaala Jukka
Published: June 2021

Objective

Data on post-stroke use of antidepressants in young individuals are scarce. We examined pattern and factors associated with initiating post-stroke antidepressants (PSAD) after ischemic stroke (IS) in young adults.

Methods

Helsinki Young Stroke Registry includes patients aged 15–49 years with first-ever IS, 1994–2007. Data on prescriptions, hospitalizations and death came from nationwide registers. We defined time of initiating PSAD as time of the first filled prescription for antidepressants within 1 year from IS. We assessed factors associated with initiating PSAD with multivariable Cox regression models, allowing for time-varying effects when appropriate.

Results

We followed 888 patients, of which 206 (23.2%) initiated PSAD. Higher hazard of starting PSAD within the first 100 days appeared among patients with mild versus no limb paresis 2.53 (95% confidence interval 1.48–4.31) and during later follow-up among those with silent infarcts (2.04; 1.27–3.28), prior use of antidepressants (2.09; 1.26–3.46) and moderate versus mild stroke (2.06; 1.18–3.58). The relative difference in the hazard rate for moderate–severe limb paresis persisted both within the first 100 days (3.84, 2.12–6.97) and during later follow-up (4.54; 2.51–8.23). The hazard rate was higher throughout the follow-up among smokers (1.48; 1.11–1.97) as well as lower (1.78; 1.25–2.54) and upper white-collar workers (2.00; 1.24–3.23) compared to blue-collar workers.

Conclusion

One-fourth of young adults started PSADs within 1 year from IS. We identified several specific clinical characteristics associated with PSAD initiation, highlighting their utility in assessing the risk of post-stroke depression during follow-up.
Flow-through isolation of human first trimester umbilical cord endothelial cells
Authors: Gruber Michael , Weiss Elisa , Siwetz Monika , Hiden Ursula , Gauster Martin
Published: June 2021

Human umbilical vein and artery endothelial cells (HUVEC; HUAEC), placental endothelial cells (fpAEC), and endothelial colony-forming cells (ECFC) from cord blood are a widely used model for researching placental vascular development, fetal and placental endothelial function, and the effect of adverse conditions in pregnancy thereon. However, placental vascular development and angiogenesis start in the first weeks of gestation, and adverse conditions in pregnancy may also affect endothelial function before term, suggesting that endothelial cells from early pregnancy may respond differently. Thus, we established a novel, gentle flow-through method to isolate pure human umbilical endothelial cells from first trimester (FTUEC). FTUEC were characterized and their phenotype was compared to the umbilical endothelium in situ as well as to other fetal endothelial cell models from term of gestation, i.e. HUVEC, fpAEC, ECFC. FTUEC possess a CD34-positive, juvenile endothelial phenotype, and can be expanded and passaged. We regard FTUEC as a valuable tool to study developmental processes as well as the effect of adverse insults in pregnancy in vitro.
Collagen transport and related pathways in Osteogenesis Imperfecta
Authors: Claeys Lauria , Storoni Silvia , Eekhoff Marelise , Elting Mariet , Wisse Lisanne , Pals Gerard , Bravenboer Nathalie , Maugeri Alessandra , Micha Dimitra
Published: June 2021

Osteogenesis Imperfecta (OI) comprises a heterogeneous group of patients who share bone fragility and deformities as the main characteristics, albeit with different degrees of severity. Phenotypic variation also exists in other connective tissue aspects of the disease, complicating disease classification and disease course prediction. Although collagen type I defects are long established as the primary cause of the bone pathology, we are still far from comprehending the complete mechanism. In the last years, the advent of next generation sequencing has triggered the discovery of many new genetic causes for OI, helping to draw its molecular landscape. It has become clear that, in addition to collagen type I genes, OI can be caused by multiple proteins connected to different parts of collagen biosynthesis. The production of collagen entails a complex process, starting from the production of the collagen Iα1 and collagen Iα2 chains in the endoplasmic reticulum, during and after which procollagen is subjected to a plethora of posttranslational modifications by chaperones. After reaching the Golgi organelle, procollagen is destined to the extracellular matrix where it forms collagen fibrils. Recently discovered mutations in components of the retrograde transport of chaperones highlight its emerging role as critical contributor of OI development. This review offers an overview of collagen regulation in the context of recent gene discoveries, emphasizing the significance of transport disruptions in the OI mechanism. We aim to motivate exploration of skeletal fragility in OI from the perspective of these pathways to identify regulatory points which can hint to therapeutic targets.
Untersuchungen von Hammerschlag aus einer Schmiedeesse im römerzeitlichen Marmorsteinbruchrevier Spitzelofen in Kärnten, Österreich
Authors: Karl Stephan , Modl Daniel , Strobl Susanne , Haubner Roland
Published: June 2021

Im römerzeitlichen Marmorsteinbruchrevier Spitzelofen in Kärnten wurden bei archäologischen Ausgrabungen metallurgische Reste aus einer Schmiedeesse gefunden, die die Bearbeitung der Werkzeuge in unmittelbarer Nähe zum Steinbruch belegen. Aus einer holzkohlehaltigen Schicht wurden drei Korngrößenfraktionen von Hammerschlag gewonnen und untersucht. In allen Proben wurden die Eisenoxide Wüstit (FeO), Magnetit (Fe3O4) und Hämatit (Fe2O3) nachgewiesen. In der feinsten Fraktion (0–0,5 mm) befanden sich eher gleichförmige Hammerschlagpartikel neben größeren Anteilen an Kalzit (Marmor) und Quarz. In den gröberen Fraktionen lag der Hammerschlag plättchenförmig vor. In den Proben konnte neben den Eisenoxiden lokal auch Schlacke und metallisches Eisen nachgewiesen werden.

Das Vorliegen von plättchenförmigem Hammerschlag zeigt, dass dieser durch Verzunderung während des Schmiedevorgangs entstanden ist und bei den verwendeten Schmiedetemperaturen die Schmelzpunkte von Gusseisen und Schlacke nicht erreicht wurden (T < 1150 °C).

Für die Nachbearbeitung von groben Bergbauwerkzeugen (Doppelspitzschlägel, Setzkeile usw.) war es vermutlich nicht notwendig, das gesamte Werkzeug auf Schmiedetemperatur zu erwärmen, sondern nur so weit, dass die gewünschte Verformung erreicht werden konnte.
Interleukin-1β and cathepsin D modulate formation of the terminal complement complex in cultured human disc tissue
Authors: Teixeira Graciosa Q. , Yong Zhiyao , Kuhn Amelie , Riegger Jana , Goncalves Raquel M. , Ruf Michael , Mauer Uwe M. , Huber-Lang Markus , Ignatius Anita , Brenner Rolf E. , Neidlinger-Wilke Cornelia
Published: June 2021

Purpose

Formation of terminal complement complex (TCC), a downstream complement system activation product inducing inflammatory processes and cell lysis, has been identified in degenerated discs. However, it remains unclear which molecular factors regulate complement activation during disc degeneration (DD). This study investigated a possible involvement of the pro-inflammatory cytokine interleukin-1β (IL-1β) and the lysosomal protease cathepsin D (CTSD).

Methods

Disc biopsies were collected from patients suffering from DD (n = 43) and adolescent idiopathic scoliosis (AIS, n = 13). Standardized tissue punches and isolated cells from nucleus pulposus (NP), annulus fibrosus (AF) and endplate (EP) were stimulated with 5% human serum (HS) alone or in combination with IL-1β, CTSD or zymosan. TCC formation and modulation by the complement regulatory proteins CD46, CD55 and CD59 were analysed.

Results

In DD tissue cultures, IL-1β stimulation decreased the percentage of TCC + cells in AF and EP (P < 0.05), whereas CTSD stimulation significantly increased TCC deposition in NP (P < 0.01) and zymosan in EP (P < 0.05). Overall, the expression of CD46, CD55 and CD59 significantly increased in all isolated cells during culture (P < 0.05). Moreover, cellular TCC deposition was HS concentration dependent but unaffected by IL-1β, CTSD or zymosan.

Conclusion

These results suggest a functional relevance of IL-1β and CTSD in modulating TCC formation in DD, with differences between tissue regions. Although strong TCC deposition may represent a degeneration-associated event, IL-1β may inhibit it. In contrast, TCC formation was shown to be triggered by CTSD, indicating a multifunctional involvement in disc pathophysiology.
Health-related quality of life after posterior vertebral column resection in children: comparison with healthy controls
Authors: Syvänen Johanna , Helenius Linda , Raitio Arimatias , Gerdhem Paul , Diarbakerli Elias , Helenius Ilkka
Published: June 2021

Purpose

Vertebral column resection (VCR) is a technique performed for short, angular spinal deformities. Several studies have reported good radiographic results with VCR regarding curve correction. However, only a few studies have reported the impact of this technique on the health-related quality-of-life measures (HRQoL).

Methods

A single surgeon series of 27 consecutive children (mean age at surgery 12.3 years, range 1.1–20.7 years) undergoing posterior VCR with a minimum of 2-year follow-up. The comparison was made to age- and gender-matched healthy controls. Outcome measures included Scoliosis Research Society (SRS) questionnaire both pre- and postoperatively, radiographic outcomes, and complications.

Results

The average major curve correction was 60.3% in the VCR patients. Complications were noted in 12 out of 27 (44%) of the VCR patients but all patients recovered fully during follow-up. The SRS pain domain scores improved significantly after VCR (p = 0.0002). The SRS total and domain scores were significantly lower than in the healthy controls especially in the self-image and function domains, but the pain and activity domains improved from preoperative to similar level than in the control group.

Conclusions

HRQoL showed significant improvement in pain scores despite 44% risk of transient complications after VCR in pediatric patients. This health-related quality-of-life improvement remained at a significantly lower level than in the healthy control group.

Level of Evidence

Therapeutic Level III.
Numerical estimates of risk factors contingent on credit ratings
Authors: Gärtner T. , Kaniovski S. , Kaniovski Y.
Published: June 2021

Assuming a favorable or an adverse outcome for every combination of a credit class and an industry sector, a binary string, termed as a macroeconomic scenario, is considered. Given historical transition counts and a model for dependence among credit-rating migrations, a probability is assigned to each of the scenarios by maximizing a likelihood function. Applications of this distribution in financial risk analysis are suggested. Two classifications are considered: 7 non-default credit classes with 6 industry sectors and 2 non-default credit classes with 12 industry sectors. We propose a heuristic algorithm for solving the corresponding maximization problems of combinatorial complexity. Probabilities and correlations characterizing riskiness of random events involving several industry sectors and credit classes are reported.
Evaluation of accelerated motion-compensated 3d water/fat late gadolinium enhanced MR for atrial wall imaging
Authors: Munoz Camila , Sim Iain , Neji Radhouene , Kunze Karl P. , Masci Pier-Giorgio , Schmidt Michaela , O’Neill Mark , Williams Steven , Botnar René M. , Prieto Claudia
Published: June 2021

Objective

3D late gadolinium enhancement (LGE) imaging is a promising non-invasive technique for the assessment of atrial fibrosis. However, current techniques result in prolonged and unpredictable scan times and high rates of non-diagnostic images. The purpose of this study was to compare the performance of a recently proposed accelerated respiratory motion-compensated 3D water/fat LGE technique with conventional 3D LGE for atrial wall imaging.

Materials and methods

18 patients (age: 55.7±17.1 years) with atrial fibrillation underwent conventional diaphragmatic navigator gated inversion recovery (IR)-prepared 3D LGE (dNAV) and proposed image-navigator motion-corrected water/fat IR-prepared 3D LGE (iNAV) imaging. Images were assessed for image quality and presence of fibrosis by three expert observers. The scan time for both techniques was recorded.

Results

Image quality scores were improved with the proposed compared to the conventional method (iNAV: 3.1 ± 1.0 vs. dNAV: 2.6 ± 1.0, p = 0.0012, with 1: Non-diagnostic to 4: Full diagnostic). Furthermore, scan time for the proposed method was significantly shorter with a 59% reduction is scan time (4.5 ± 1.2 min vs. 10.9 ± 3.9 min, p < 0.0001). The images acquired with the proposed method were deemed as inconclusive less frequently than the conventional images (expert 1/expert 2: 4/7 dNAV and 2/4 iNAV images inconclusive).

Discussion

The motion-compensated water/fat LGE method enables atrial wall imaging with diagnostic quality comparable to the current conventional approach with a significantly shorter scan of about 5 min.
Density-dependent behavioural interactions influence coexistence between a native and a non-native mesopredator
Authors: Jakubavičiūtė Eglė , Candolin Ulrika
Published: June 2021

The invasion of non-native species into an ecosystem can markedly alter the structure and functioning of the system. Yet, we have limited knowledge of the factors that determine invasion success. Behavioural interactions have been suggested as critical determinants of invasion success in animals, but the exact mechanisms are less well known. We investigated if density-dependent behavioural interactions could have facilitated the invasion of the shrimpPalaemon elegansinto the spawning habitat of the threespine sticklebackGasterosteus aculeatusin the Baltic Sea. This was done by manipulating the densities of the two species in mesocosms. We found the stickleback to dominate behaviourally over the shrimp through higher aggression, but that the impact on the shrimp was density-dependent; a high density of sticklebacks increased aggressive interactions, which caused the shrimps to decrease their activity and restrict their habitat use to dense vegetation, while a low density of sticklebacks had no impact on the distribution and activity of the shrimps. The density of the shrimps had no impact on stickleback behaviour. These results suggest that the present density of the stickleback has allowed the invasion of the shrimp into the habitat. However, a current increase in stickleback abundance caused by human-induced ecological disturbances could limit the further expansion of the shrimp. Thus, our results indicate that a behavioural mechanism–density-dependent aggression–can influence invasion success and subsequent population expansion. At a broader level, our results stress the importance of considering density-dependent behavioural interactions when investigating the mechanisms behind invasion success.
Changes in colorectal cancer knowledge and screening intention among Ohio African American and Appalachian participants: The screen to save initiative
Authors: Boutsicaris Andrew S. , Fisher James L. , Gray Darrell M. , Adeyanju Toyin , Holland Jacquelin S. , Paskett Electra D.
Published: June 2021

African Americans and Appalachians experience greater incidence and mortality rates of colorectal cancer due to factors, such as reduced prevalence of screening. An educational session (the Screen to Save Initiative) was conducted to increase intent to screen for colorectal cancer among African Americans and Appalachians in Ohio. Using a community-based approach, from April to September 2017, 85 eligible participants were recruited in Franklin County and Appalachia Ohio. Participants completed a knowledge assessment on colorectal cancer before and after participating in either an educational PowerPoint session or a guided tour through an Inflatable Colon. Logistic regression models were used to determine what factors were associated with changes in colorectal cancer knowledge and intent to screen for colorectal cancer. The majority (71.79%) of participants gained knowledge about colorectal cancer after the intervention. Multivariate results showed that race (OR = 0.30; 95% CI: 0.11–0.80 for African Americans versus White participants) and intervention type (OR = 5.97; 95% CI: 1.94–18.43 for PowerPoint versus Inflatable Colon) were associated with a change in knowledge. The association between education and intent to screen was marginally statistically significant (OR = 0.42; 95% CI: 0.16–1.13 for college graduate versus not a college graduate). A change in colorectal cancer knowledge was not associated with intent to screen. Future educational interventions should be modified to increase intent to screen and screening for colorectal cancer. Further research with these modified interventions should aim to reduce disparities in CRC among underserved populations while listening to the voices of the communities.
CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue
Authors: Schmid Andreas , Schäffler Andreas , Karrasch Thomas
Published: June 2021

The anti-inflammatory adipokine CTRP-3 might affect innate immune reactions such as NOD1. The impact of CTRP-3 on NOD1-mediated inflammation in adipocytes and monocytic cells as well as on NOD1 expression was investigated. Murine 3T3-L1 pre-adipocytes and adipocytes as well as human THP-1 monocyte-like cells were co-stimulated with the synthetic NOD1 agonist Tri-DAP and recombinant CTRP-3. Gonadal adipose tissue and primary adipocytes were obtained from a murine model carrying a knockout (KO) of CTRP-3 in adipocytes but not in stroma-vascular cells. Wildtype mice with lipopolysaccharide (LPS)-induced elevated NOD1 expression were treated with CTRP-3. Secreted inflammatory cytokines in cell supernatants were measured by ELISA and mRNA levels were quantified by RT-PCR. Pro-inflammatory chemokine and cytokine secretion (MCP-1, RANTES, TNFα) was induced by NOD1 activation in adipocytes and monocyte-like cells, and MCP-1 and RANTES release was effectively inhibited by pre-incubation of cells with CTRP-3. CTRP-3 also antagonized LPS-triggered induction of NOD1 gene expression in murine adipose tissue, whereas adipocyte CTRP-3 deficiency upregulated NOD1 expression in adipose tissue. CTRP-3 is an effective antagonist of peptidoglycan-induced, NOD1-mediated inflammation and of LPS-induced NOD1 expression. Since basal NOD1 expression is increased by adipocyte CTRP-3 deficiency, there have to be also inflammation-independent mechanisms of NOD1 expression regulation by CTRP-3.
Evaluation of log P, pKa, and log D predictions from the SAMPL7 blind challenge
Authors: Bergazin Teresa Danielle , Tielker Nicolas , Zhang Yingying , Mao Junjun , Gunner M. R. , Francisco Karol , Ballatore Carlo , Kast Stefan M. , Mobley David L.
Published: June 2021

The Statistical Assessment of Modeling of Proteins and Ligands (SAMPL) challenges focuses the computational modeling community on areas in need of improvement for rational drug design. The SAMPL7 physical property challenge dealt with prediction of octanol-water partition coefficients and pKa for 22 compounds. The dataset was composed of a series of N-acylsulfonamides and related bioisosteres. 17 research groups participated in the log P challenge, submitting 33 blind submissions total. For the pKa challenge, 7 different groups participated, submitting 9 blind submissions in total. Overall, the accuracy of octanol-water log P predictions in the SAMPL7 challenge was lower than octanol-water log P predictions in SAMPL6, likely due to a more diverse dataset. Compared to the SAMPL6 pKa challenge, accuracy remains unchanged in SAMPL7. Interestingly, here, though macroscopic pKa values were often predicted with reasonable accuracy, there was dramatically more disagreement among participants as to which microscopic transitions produced these values (with methods often disagreeing even as to the sign of the free energy change associated with certain transitions), indicating far more work needs to be done on pKa prediction methods.
A review on the direct electroplating of polymeric materials
Authors: Augustyn Piotr , Rytlewski Piotr , Moraczewski Krzysztof , Mazurkiewicz Adam
Published: June 2021

This work is a review of the literature on the possibilities for electroplating of polymer materials. Methods of metalizing polymers and their composites were presented and discussed. Information from various publications on the electrical properties of polymers and polymer composites was collected and discussed. The most important results on the electroplating of conductive polymers and conductive composites were presented and compared. This work especially focuses on the electrical conductivity of polymer materials. The main focus was the efficiency of metal electrodeposition. Based on the analyzed publications, it was found that electrically deposited metal layers on conductive polymeric materials show discontinuity, considerable roughness, and different layer thickness depending on the distance from the contact electrode. The use of metal nanoparticles (AgNWs) or nickel nanoparticles (NiNPs) as a filler enables effective metallization of the polymer composite. Due to the high aspect ratio, it is possible to lower the percolation threshold with a low filler content in the polymer matrix. The presented review reveals many of the problems associated with the effectiveness of the electroplating methods. It indicates the need and direction for further research and development in the field of electroplating of polymer materials and modification of their electrical properties.
Children Fleeing Domestic Violence to Emergency Accommodations: Education Rights and Experiences
Authors: Selvik Sabreen , Thjømøe Cathrine
Published: June 2021

Domestic violence forces many families to flee to emergency accommodations. This article focuses on children’s experiences of schooling and life at confidential addresses, and to what extent their legal right to education in the face of domestic violence is safeguarded in practice. Data were collected from interviews with 20 children aged 6–16 with multiple relocations at Norwegian refuges for abused women. Interviews were coded using the constructive approach to grounded theory. Data were analyzed using Antonovsky's theory and interpreted within the context of Norwegian and international law, examining the rights of children to education versus the legal rights of abusers. The findings indicate that children’s rights to education and a life without violence may be sacrificed in favor of due process for abusers. The article suggests concrete protective measures to help safeguard these rights, and calls on policymakers and support agencies worldwide to rethink their policies and practice.
Tenants’ residential mobility in Switzerland: the role of housing functions
Authors: Pagani Anna , Baur Ivo , Binder Claudia R.
Published: June 2021

The interaction between residential preferences and dwellings is a complex system whose function thus far remains insufficiently explored. In this paper, we investigate housing functions as orchestrators of households’ residential mobility in the context of Swiss rental housing. We propose a theoretical multi-step model and use survey data from 878 Swiss tenants to inspect the model’s linkages. From the statistical analysis, we firstly observe that tenants’ residential satisfaction is more likely to increase when the gap between ideal housing functions and those actually fulfilled by the current dwelling decreases. Secondly, results show that the effectiveness of an event (e.g. a job opportunity) in triggering the move is significantly related to both residential satisfaction and the functions the dwelling fulfils prior to the trigger. Thirdly, findings show that these trigger events can be grouped into three types: radical change, problem-solving and opportunity. With a medium effect size, a radical change was found to bring about the strongest change in housing functions between past and current dwellings. Lastly, in line with the hypothesis that residential preferences vary over the life course, socio-demographic characteristics and tenancy types are found to be significant explanatory variables for households’ ideal housing functions. By disentangling the complexity of the housing system, the proposed multi-step model can be used to integrate households’ preferences with supply-side constraints in agent-based model simulations, thereby contributing to fostering the provision of quality housing, i.e. dwellings able to meet the needs of current and future occupants.
A consistent model for estimating the partitioning of Am, Pu and Se in agricultural soils
Authors: Hormann Volker
Published: June 2021

The component additive model UNiSeCs II for simulating the physicochemical behaviour of the radionuclides americium, plutonium and selenium in agricultural soils is presented. The model is validated by estimating the distribution coefficients (Kd) of these elements measured in batch experiments from the literature. For all three elements, the resulting average relative deviations from the experimental values are smaller than a factor of 2.5. This indicates that the model has the potential to significantly improve the predictions of radioecological models that normally use tabulated Kd values from the IAEA which are known to have large uncertainties. Using UNiSeCs II, the soil solution parameters most important for the partitioning of Am, Pu and Se are identified by single parameter variations.
Bayesian optimization with safety constraints: safe and automatic parameter tuning in robotics
Authors: Berkenkamp Felix , Krause Andreas , Schoellig Angela P.
Published: June 2021

Selecting the right tuning parameters for algorithms is a pravelent problem in machine learning that can significantly affect the performance of algorithms. Data-efficient optimization algorithms, such as Bayesian optimization, have been used to automate this process. During experiments on real-world systems such as robotic platforms these methods can evaluate unsafe parameters that lead to safety-critical system failures and can destroy the system. Recently, a safe Bayesian optimization algorithm, called SafeOpt, has been developed, which guarantees that the performance of the system never falls below a critical value; that is, safety is defined based on the performance function. However, coupling performance and safety is often not desirable in practice, since they are often opposing objectives. In this paper, we present a generalized algorithm that allows for multiple safety constraints separate from the objective. Given an initial set of safe parameters, the algorithm maximizes performance but only evaluates parameters that satisfy safety for all constraints with high probability. To this end, it carefully explores the parameter space by exploiting regularity assumptions in terms of a Gaussian process prior. Moreover, we show how context variables can be used to safely transfer knowledge to new situations and tasks. We provide a theoretical analysis and demonstrate that the proposed algorithm enables fast, automatic, and safe optimization of tuning parameters in experiments on a quadrotor vehicle.