bluuebunny/crossref_metadata_2025 huggingface dataset:
AI-Empowered Computational Examination of Chest Imaging for COVID-19 Treatment: A Review
Authors: Deng Hanqiu , Li Xingyu
Published: July 2021

Since the first case of coronavirus disease 2019 (COVID-19) was discovered in December 2019, COVID-19 swiftly spread over the world. By the end of March 2021, more than 136 million patients have been infected. Since the second and third waves of the COVID-19 outbreak are in full swing, investigating effective and timely solutions for patients’ check-ups and treatment is important. Although the SARS-CoV-2 virus-specific reverse transcription polymerase chain reaction test is recommended for the diagnosis of COVID-19, the test results are prone to be false negative in the early course of COVID-19 infection. To enhance the screening efficiency and accessibility, chest images capturedviaX-ray or computed tomography (CT) provide valuable information when evaluating patients with suspected COVID-19 infection. With advanced artificial intelligence (AI) techniques, AI-driven models training with lung scans emerge as quick diagnostic and screening tools for detecting COVID-19 infection in patients. In this article, we provide a comprehensive review of state-of-the-art AI-empowered methods for computational examination of COVID-19 patients with lung scans. In this regard, we searched for papers and preprints on bioRxiv, medRxiv, and arXiv published for the period from January 1, 2020, to March 31, 2021, using the keywords of COVID, lung scans, and AI. After the quality screening, 96 studies are included in this review. The reviewed studies were grouped into three categories based on their target application scenarios: automatic detection of coronavirus disease, infection segmentation, and severity assessment and prognosis prediction. The latest AI solutions to process and analyze chest images for COVID-19 treatment and their advantages and limitations are presented. In addition to reviewing the rapidly developing techniques, we also summarize publicly accessible lung scan image sets. The article ends with discussions of the challenges in current research and potential directions in designing effective computational solutions to fight against the COVID-19 pandemic in the future.
Fathers Matter: Enhancing Healthcare Experiences Among Fathers of Children With Developmental Disabilities
Authors: Ogourtsova Tatiana , O'Donnell Maureen E. , Chung Derrick , Gavin Frank , Bogossian Aline , Majnemer Annette
Published: July 2021

Background: Being a parent of a child with a developmental disability (DD; e. g., cerebral palsy, autism) comes with great challenges and apprehensions. Mothers and fathers of children with DD are experiencing heightened levels of psychological distress, physical health problems, financial difficulties, social isolation, and struggles with respect to traditional parenting roles. In relation to the latter, the involvement of fathers in caregiving in today's society is increasing and is highlighted by its importance and positive contribution to the development of their children. However, fathers of children with DD report feeling excluded and marginalized by healthcare providers (HCPs) when arranging for and getting involved in healthcare services for their children. Currently, there is limited evidence as to what factors influence those experiences. We aimed to explore barriers to and facilitators of positive and empowering healthcare experiences, from the perspectives of fathers of children with DD and HCPs.

Methods: A mixed-method approach, such as quantitative (survey) and qualitative (semi-structured interview) strategies, was used. Participants were fathers of children with DD and HCPs working in childhood disability. Data analysis consisted of using descriptive statistics and an inductive-thematic analysis of emergent themes.

Results: Fathers (n = 7) and HCPs (n = 13, 6 disciplines) participated. The fathers indicated that while they were moderate to very much satisfied with their interactions with HCPs, they reported that HCPs were only sometimes attentive to them during interactions. Fathers also revealed that positive interactions with HCPs in relation to their children had multiple benefits. Several themes related to barriers and facilitators of optimal interactions and parent–professional relationships emerged. These included session factors (time, attention), personal factors (knowledge of the condition, child and healthcare system, acceptance vs. denial, previous experiences, culture, stereotypes, pre-existing beliefs, stress levels, working schedule), and family dynamics. The participants offered several insights into the different strategies that can be implemented to promote optimal interactions between fathers and HCPs.

Conclusion: We identified several barriers, facilitators, and improvement strategies for optimal interactions and enhanced parent–professional relationships from the perspectives of fathers and HCPs. These can be integrated by existing clinical settings in efforts to enhance current clinical practices and improve child- and parent-related outcomes.
Advection Not Dispersion and Transient Storage Controls Streambed Nutrient and Greenhouse Gas Concentrations
Authors: Comer-Warner Sophie A. , Blaen Phillip J. , Brekenfeld Nicolai , Gooddy Daren C. , Lovell Christopher , Khamis Kieran , Bryden Alexandra , Krause Stefan
Published: July 2021

Streams and rivers are globally important in the carbon and nitrogen cycles due to high carbon and nitrogen turnover rates and contribute disproportionately to global greenhouse gas (GHG) emissions relative to their areal coverage. The hyporheic zone may be a hotspot of biogeochemical reactivity within fluvial ecosystems resulting in high rates of nutrient attenuation and associated GHG production. Controls on streambed nutrient cycling and particularly GHG production remain insufficiently understood. In this study, porewater concentrations of nutrients (NH4+,NO3-,NO2-) and GHGes (CO2, CH4, N2O) were measured alongside surface water breakthrough curves (BTC) of conservative (uranine) and reactive tracers [resazurin (raz)-resorufin (rru)] to provide insights into often assumed correlations between in-stream advective transport and transient storage metrics, and streambed biogeochemistry. Streambed biogeochemical concentrations were significantly correlated with advective transport time but not with dispersion and transient storage. The effect of advective transport time varied between chemical species, withNH4+, CO2, and CH4exhibiting positive correlations andNO3-,NO2-, and N2O displaying negative correlations with advective transport time and vice versa for long-term storage. These findings increase knowledge of the relationship between hydrological drivers and streambed chemistry, potentially highlighting areas of the streambed expected to have elevated nutrients and GHGs. This improved understanding may allow chemical species to be effectively targeted by morphological restoration, which will aid in effective pollution and climate remediation.
Changing Patterns of Sustainable Food Consumption Regarding Environmental and Social Impact-Insights From Slovakia
Authors: Holotová Mária , Horská Elena , Nagyová Ĺudmila
Published: July 2021

Food consumption accounts for almost one-third of households' total environmental impact. Nowadays, consumption patterns throughout Europe are totally different from those of couple years ago, Slovakia is no exception. At an individual level, people's consumption patterns are shaped by their needs, abilities and opportunities. Exploring and understanding consumers' attitudes toward sustainable food consumption tendences is a key element to a better future for every country. This paper presents an analysis of the current situation regarding sustainable food habits among Slovak consumers. The main aim is to determine the level of consumer awareness for sustainable food consumption and food waste through purchasing decisions. Marketing research was conducted as a part of European project in five partner countries, we present results for Slovakia. Based on the analysis, we will be able in future to define limitations and opportunities in the form of recommendations in future. The findings of this paper have significant contributions and may encourage the process for the discussions and to provide the basis for educational content to help adults develop their skills and behaviors to make food consumption more sustainable.
HIV Modifies the m6A and m5C Epitranscriptomic Landscape of the Host Cell
Authors: Cristinelli Sara , Angelino Paolo , Janowczyk Andrew , Delorenzi Mauro , Ciuffi Angela
Published: July 2021

The study of RNA modifications, today known as epitranscriptomics, is of growing interest. The N6-methyladenosine (m6A) and 5-methylcytosine (m5C) RNA modifications are abundantly present on mRNA molecules, and impact RNA interactions with other proteins or molecules, thereby affecting cellular processes, such as RNA splicing, export, stability, and translation. Recently m6A and m5C marks were found to be present on human immunodeficiency (HIV) transcripts as well and affect viral replication. Therefore, the discovery of RNA methylation provides a new layer of regulation of HIV expression and replication, and thus offers novel array of opportunities to inhibit replication. However, no study has been performed to date to investigate the impact of HIV replication on the transcript methylation level in the infected cell. We used a productive HIV infection model, consisting of the CD4+ SupT1 T cell line infected with a VSV-G pseudotyped HIVeGFP-based vector, to explore the temporal landscape of m6A and m5C epitranscriptomic marks upon HIV infection, and to compare it to mock-treated cells. Cells were collected at 12, 24, and 36 h post-infection for mRNA extraction and FACS analysis. M6A RNA modifications were investigated by methylated RNA immunoprecipitation followed by high-throughput sequencing (MeRIP-Seq). M5C RNA modifications were investigated using a bisulfite conversion approach followed by high-throughput sequencing (BS-Seq). Our data suggest that HIV infection impacted the methylation landscape of HIV-infected cells, inducing mostly increased methylation of cellular transcripts upon infection. Indeed, differential methylation (DM) analysis identified 59 m6A hypermethylated and only 2 hypomethylated transcripts and 14 m5C hypermethylated transcripts and 7 hypomethylated ones. All data and analyses are also freely accessible on an interactive web resource (http://sib-pc17.unil.ch/HIVmain.html). Furthermore, both m6A and m5C methylations were detected on viral transcripts and viral particle RNA genomes, as previously described, but additional patterns were identified. This work used differential epitranscriptomic analysis to identify novel players involved in HIV life cycle, thereby providing innovative opportunities for HIV regulation.
Interactive Graph Stream Analytics in Arkouda
Authors: Du Zhihui , Rodriguez Oliver Alvarado , Patchett Joseph , Bader David A.
Published: July 2021

Data from emerging applications, such as cybersecurity and social networking, can be abstracted as graphs whose edges are updated sequentially in the form of a stream. The challenging problem of interactive graph stream analytics is the quick response of the queries on terabyte and beyond graph stream data from end users. In this paper, a succinct and efficient double index data structure is designed to build the sketch of a graph stream to meet general queries. A single pass stream model, which includes general sketch building, distributed sketch based analysis algorithms and regression based approximation solution generation, is developed, and a typical graph algorithm—triangle counting—is implemented to evaluate the proposed method. Experimental results on power law and normal distribution graph streams show that our method can generate accurate results (mean relative error less than 4%) with a high performance. All our methods and code have been implemented in an open source framework, Arkouda, and are available from our GitHub repository, Bader-Research. This work provides the large and rapidly growing Python community with a powerful way to handle terabyte and beyond graph stream data using their laptops.
Combining Ability and Gene Action Controlling Grain Yield and Its Related Traits in Bread Wheat under Heat Stress and Normal Conditions
Authors: Kamara Mohamed M. , Ibrahim Khaled M. , Mansour Elsayed , Kheir Ahmed M. S. , Germoush Mousa O. , Abd El-Moneim Diaa , Motawei Mohamed I. , Alhusays Ahmed Y. , Farid Mona Ali , Rehan Medhat
Published: July 2021

High temperature is a major environmental stress that devastatingly affects wheat production. Thenceforth, developing heat-tolerant and high-yielding wheat genotypes has become more critical to sustaining wheat production particularly under abrupt climate change and fast-growing global population. The present study aimed to evaluate parental genotypes and their cross combinations under normal and heat stress conditions, exploring their diversity based on dehydration-responsive element-binding 2 gene (DREB, stress tolerance gene in response to abiotic stress) in parental genotypes, and determining gene action controlling yield traits through half-diallel analysis. Six diverse bread wheat genotypes (local and exotic) and their 15 F1 hybrids were evaluated at two different locations under timely and late sowing dates. Sowing date, location, genotype, and their interactions significantly impacted the studied traits; days to heading, chlorophyll content, plant height, grain yield, and its attributes. Cluster analysis classified the parents and their crosses into four groups varying from heat-tolerant to heat-sensitive based on heat tolerance indices. The parental genotypes P2 and P4 were identified as an excellent source of beneficial alleles for earliness and high yielding under heat stress. This was corroborated by DNA sequence analysis of DREB transcription factors. They were the highest homologies for dehydrin gene sequence with heat-tolerant wheat species. The hybrid combinations of P1 × P5, P1 × P6, P2 × P4, and P3 × P5 were detected to be good specific combiners for grain yield and its attributes under heat stress conditions. These designated genotypes could be used in wheat breeding for developing heat-tolerant and climate-resilient cultivars. The non-additive genetic variances were preponderant over additive genetic variances for grain yield and most traits under both sowing dates. The narrow-sense heritability ranged from low to moderate for most traits. Strong positive associations were detected between grain yield and each of chlorophyll content, plant height, number of grains/spike, and thousand-grain weights, which suggest their importance for indirect selection under heat stress, especially in early generations, due to the effortlessness of their measurement.
Carbon, Nitrogen and Phosphorus Cycling in Cropland and Grassland Ecosystems
Authors: Klumpp Katja
Published: July 2021

Croplands and grasslands have a multifunctional role in biomass production for livestock and human needs [...]
Improving Equine Welfare through Human Habit Formation
Authors: White Jo , Sims Ruth
Published: July 2021

This paper explores the potential for interventions to develop pro-animal welfare habitual behaviours (PAWHBs) in people to improve the lives of animals. Human behavioural research indicates that opportunities exist to deliver lasting change through developing positive habitual behaviours. The routine nature of many equine care and management practices lends itself to habit formation and maintenance. This proof-of-concept paper aims to evaluate a theory-based intervention of developing and maintaining a PAWHB in people caring for equines. Qualitative research methods were used. A 30 day PAWHB intervention (PAWHBInt) of providing enrichment to an equine by scratching them in a consistent context linked to an existing routine behaviour was undertaken. Participants (n = 9) then engaged in semi-structured interviews that were analysed using thematic analysis, where the participants self-reported the outcomes they observed during the intervention. The study findings suggest that the PAWHBInt had a positive impact on human behaviour and habit formation. The research helps to address the dearth of evidence regarding the application of habit theory to equine welfare interventions and emphasised linking a desired new behaviour to an existing routine behaviour when developing PAWHBs. The research also highlights the role of mutual benefit for human and equine, and emotion in providing feedback and potential reward, supporting the link to the cue-routine-reward principle of habit theory.
Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model
Authors: Ahn Youngbeom , Jung Ji Young , Kweon Ohgew , Veach Brian T. , Khare Sangeeta , Gokulan Kuppan , Piñeiro Silvia A. , Cerniglia Carl E.
Published: July 2021

Studying potential dietary exposure to antimicrobial drug residues via meat and dairy products is essential to ensure human health and consumer safety. When studying how antimicrobial residues in food impact the development of antimicrobial drug resistance and disrupt normal bacteria community structure in the intestine, there are diverse methodological challenges to overcome. In this study, traditional cultures and molecular analysis techniques were used to determine the effects of tetracycline at chronic subinhibitory exposure levels on human intestinal microbiota using an in vitro continuous flow bioreactor. Six bioreactor culture vessels containing human fecal suspensions were maintained at 37 °C for 7 days. After a steady state was achieved, the suspensions were dosed with 0, 0.015, 0.15, 1.5, 15, or 150 µg/mL tetracycline, respectively. Exposure to 150 µg/mL tetracycline resulted in a decrease of total anaerobic bacteria from 1.9 × 107 ± 0.3 × 107 down to 2 × 106 ± 0.8 × 106 CFU/mL. Dose-dependent effects of tetracycline were noted for perturbations of tetB and tetD gene expression and changes in acetate and propionate concentrations. Although no-observed-adverse-effect concentrations differed, depending on the traditional cultures and the molecular analysis techniques used, this in vitro continuous flow bioreactor study contributes to the knowledge base regarding the impact of chronic exposure of tetracycline on human intestinal microbiota.
In Vitro and In Silico Approaches for the Antileishmanial Activity Evaluations of Actinomycins Isolated from Novel Streptomyces smyrnaeus Strain UKAQ_23
Authors: Qureshi Kamal A. , Al Nasr Ibrahim , Koko Waleed S. , Khan Tariq A. , Fatmi M. Qaiser , Imtiaz Mahrukh , Khan Riaz A. , Mohammed Hamdoon A. , Jaremko Mariusz , Emwas Abdul-Hamid , Azam Faizul , Bholay Avinash D. , Elhassan Gamal O. , Prajapati Dinesh K.
Published: July 2021

Leishmaniasis, a Neglected Tropical Parasitic Disease (NTPD), is induced by several Leishmania species and is disseminated through sandfly (Lutzomyia longipalpis) bites. The parasite has developed resistance to currently prescribed antileishmanial drugs, and it has become pertinent to the search for new antileishmanial agents. The current study aimed to investigate the in vitro and in silico antileishmanial activity of two newly sourced actinomycins, X2 and D, produced by the novel Streptomyces smyrnaeus strain UKAQ_23. The antileishmanial activity conducted on promastigotes and amastigotes of Leishmania major showed actinomycin X2 having half-maximal effective concentrations (EC50), at 2.10 ± 0.10 μg/mL and 0.10 ± 0.0 μg/mL, and selectivity index (SI) values of 0.048 and 1, respectively, while the actinomycin D exhibited EC50 at 1.90 ± 0.10 μg/mL and 0.10 ± 0.0 μg/mL, and SI values of 0.052 and 1. The molecular docking studies demonstrated squalene synthase as the most favorable antileishmanial target protein for both the actinomycins X2 and D, while the xanthine phosphoribosyltransferase was the least favorable target protein. The molecular dynamics simulations confirmed that both the actinomycins remained stable in the binding pocket during the simulations. Furthermore, the MMPBSA (Molecular Mechanics Poisson-Boltzmann Surface Area) binding energy calculations established that the actinomycin X2 is a better binder than the actinomycin D. In conclusion, both actinomycins X2 and D from Streptomyces smyrnaeus strain UKAQ_23 are promising antileishmanial drug candidates and have strong potential to be used for treating the currently drug-resistant leishmaniasis.
Identification of Antibiotics in Surface-Groundwater. A Tool towards the Ecopharmacovigilance Approach: A Portuguese Case-Study
Authors: Viana Paula , Meisel Leonor , Lopes Ana , de Jesus Rosário , Sarmento Georgina , Duarte Sofia , Sepodes Bruno , Fernandes Ana , dos Santos Margarida M. Correia , Almeida Anabela , Oliveira M. Conceição
Published: July 2021

Environmental monitoring, particularly of water, is crucial to screen and preselect potential hazardous substances for policy guidance and risk minimisation strategies. In Portugal, extensive data are missing. This work aimed to perform a qualitative survey of antibiotics in surface- groundwater, reflecting demographic, spatial, consumption and drug profiles during an observational period of three years. A passive sampling technique (POCIS) and high-resolution chromatographic system were used to monitor and analyse the antibiotics. The most frequently detected antibiotics were enrofloxacin/ciprofloxacin and tetracycline in surface-groundwater, while clarithromycin/erythromycin and sulfamethoxazole were identified only in surface water. The detection of enzyme inhibitors (e.g., tazobactam/cilastatin) used exclusively in hospitals and abacavir, a specific human medicine was also noteworthy. North (Guimarães, Santo Tirso and Porto) and South (Faro, Olhão and Portimão) Portugal were the regions with the most significant frequency of substances in surface water. The relatively higher detection downstream of the effluent discharge points compared with a low detection upstream could be attributed to a low efficiency in urban wastewater treatment plants and an increased agricultural pressure. This screening approach is essential to identify substances in order to perform future quantitative risk assessment and establishing water quality standards. The greatest challenge of this survey data is to promote an ecopharmacovigilance framework, implement measures to avoid misuse/overuse of antibiotics and slow down emission and antibiotic resistance.
Pharmaceuticals in Wastewater Treatment Plants: A Systematic Review on the Substances of Greatest Concern Responsible for the Development of Antimicrobial Resistance
Authors: Frascaroli Gabriele , Reid Deborah , Hunter Colin , Roberts Joanne , Helwig Karin , Spencer Janice , Escudero Ania
Published: July 2021

In recent years, there is a growing concern about the alarming spread of antimicrobial resistance (AMR) in different environments. Increasingly, many species of bacteria, fungi and viruses are becoming immune to the most commonly used pharmaceuticals. One of the causes of the development of the resistance is the persistence of these drugs, excreted by humans, in municipal and hospital wastewater (WW). Consequently, wastewater treatment plants (WWTPs) are a primary source of antimicrobial resistance genes as novel pollutants. This systematic review sought to examine the relevant literature on pharmaceutical residues (PRs) responsible for AMR in municipal and hospital WW in order to propose a classification of the PRs of greatest concern and provide an updated source for AMR management in WWTPs. Among 546 studies collected from four databases, 18 were included in the present review. The internal and external validity of each study was assessed, and the risk of bias was evaluated on a 20-parameter basis. Results were combined in a narrative synthesis discussing influent and effluent PR concentrations at 88 WWTPs, seasonal variations, differences between hospital and municipal WW, environmental risk assessment values of antimicrobial substances and treatment facilities removal efficiencies. Among the 45 PRs responsible for AMR evaluated in this study, the antibiotics ciprofloxacin, clarithromycin, erythromycin, metronidazole, ofloxacin, sulfamethoxazole and trimethoprim constitute a considerable risk in terms of ubiquitous distribution, worrying concentrations, risk quotient values and resistance to removal treatments. Gaps in knowledge, data and information reported in this review will provide a valuable source for managing AMR in WWTPs.
Effect of African Catfish Mucilage Concentration on Stability of Nanoemulsion Using D-Optimal Mixture Design
Authors: Oluwole Adebanji Olasupo , Ikhu-Omoregbe Daniel Imwansi , Jideani Victoria Adaora , Ntwampe Seteno Karabo
Published: July 2021

Nanoemulsions are alternative means of incorporating functional components into systems. This research aims to model the effect of African catfish mucilage (ACM) concentrations on the particle size (PS) of stable oil-in-water (O/W) nanoemulsions formulated by ultrasonication. A D-optimal mixture design was used to study the influence of three mixture components (MCs) ACM, oil, and water on PS. Morphology and PS were determined with Cryo-TEM and Zetasizer. Findings show that the higher the ACM–emulsifier oil ratio, the higher the nanoemulsion stability as depicted by lower PS. ACM concentration was the factor that had the most dominant effect on the dependent variable (DV) PS. Morphology studies revealed that structural stability was a result of ACM which encapsulated the nanoemulsion by mucoadhesion. The model’s lack of fit (F [0.17, 0.11] = 0.3104; p = 1.49) was not significant, and the predicted R-squared value was 0.9977 and adequate precision was 104.158 indicating a model with adequate goodness-of-fit. The model was adequate to determine the effects of the three MCs on the precise stability parameter for the investigated dependent variable particle size. Therefore, ACM could be used as a natural stabilizer in oil-in-water nanoemulsions that are applicable in biomedical and personal care industries.
Numerical Simulation of Electric Field Distribution around an Instrumented Total Hip Stem
Authors: Zimmermann Ulf , Ebner Cathérine , Su Yukun , Bender Thomas , Bansod Yogesh Deepak , Mittelmeier Wolfram , Bader Rainer , van Rienen Ursula
Published: July 2021

Presently, total joint replacement (TJR) is a standard procedure in orthopedic surgery. Adequate osseointegration of the implant components still remains a clinical issue. However, active stimulation of bone tissue to enhance bone ongrowth at the implant surfaces has not been widely investigated so far. For the last several years, invasive electromagnetically induced osseotherapy has been employed in clinical practice, e.g., for the treatment of avascular necrosis, femoral neck fractures, and pseudarthrosis. In the present study, the approach of exploiting the electric stimulation effect was transferred to the field of TJR. Therefore, a commercially available total hip stem was instrumented with an electrode on its surface in order to generate an electric field supporting the regeneration of the surrounding bone tissue. The objective was to conduct numerical simulations validated by experimental investigations as a proof of concept for an instrumented electro-stimulative total hip stem. The results revealed that the calculated electric field around a total hip stem fulfills the requirements to stimulate adjacent bone tissue when using clinically applied electric voltages. The derived numerical and experimental data of electric potentials and corresponding electric fields are encouraging for the implementation of active electrical stimulation in uncemented total hip stems to enhance their osseointegration.
A Proposal for a Standardized Approach to Inducing Low Energy Availability in Athletes
Authors: Jurov Iva , Keay Nicola , Hadžić Vedran , Rauter Samo
Published: July 2021

Low energy availability in athletes is an insufficiently researched phenomenon due to lack of a universal methodology. Current objective and subjective methods for assessing low energy availability lack in accuracy, are not used with a standardized approach and fail to provide comparable, consistent results. Research in male athletes is even more challenging than in females. It is still not known what the threshold for low energy availability is when negative effects on health and performance occur. This is why in this paper a two-way standardized, systematic and controlled protocol for inducing low energy availability in free-living athletes is proposed. Ways of inducing low energy availability in athletes are described with a systematic approach to ensure accurate results. We suggest this is how new tools for assessing low energy availability can be developed with less burden on the athlete and the scientist. Analysis of each proposed protocol provides a rationale for their use. Future research directions are suggested for determining the threshold for low energy availability and determining the critical duration for its negative effects. Finally, we suggest a practical outcome of using the proposed research approach for health practitioners and coaches in order to protect athlete’s well-being.
The Effect of Rectus Abdominis Fatigue on Lower Limb Jumping Performance and Landing Load for Volleyball Players
Authors: Lin Hui-Ting , Huang Yin-Che , Li Yen-Yi , Chang Jia-Hao
Published: July 2021

The aim of this study was to investigate the effects of rectus abdominis (RA) fatigue on the jumping performance and landing loads of volleyball players during countermovement jumps (CMJs) and spike jumps (SPJs). Twelve healthy university volleyball players were evaluated using a three-dimensional motion analysis system, force plates, and surface electromyography (EMG). The lowest center of mass (Min-CoM), maximum jumping height (Max-JH), angles of joints at take-off and landing, joint moment of the lower limbs, and EMG parameters of the RA, erector spinae, and lower limb muscles, when performing the CMJs and SPJs, were recorded before and after a 10 min RA muscle fatigue intervention. After RA fatigue, the Max-JH was significantly reduced, and the lowest Min-CoM was significantly increased. The take-off angles changed significantly at the ankle (SPJ), knee (CMJ), and hip (SPJ), and the plantar flexion torque changed significantly at the SPJ touchdown. The contribution ratio of the feet during SPJs and CMJs changed after fatigue. Temporary RA fatigue decreases the jump height of athletes and causes a change in the landing strategy.
Implementing Ethical, Legal, and Societal Considerations in Wearable Robot Design
Authors: Kapeller Alexandra , Felzmann Heike , Fosch-Villaronga Eduard , Nizamis Kostas , Hughes Ann-Marie
Published: July 2021

Ethical, legal and societal implications (ELSI) in the development of wearable robots (WRs) are currently not explicitly addressed in most guidelines for WR developers. Previous work has identified ELSI related to WRs, e.g., impacts on body and identity, ableism, data protection, control and responsibilities, but translation of these concerns into actionable recommendations remains outstanding. This paper provides practical guidance for the implementation of ELSI in WR design, development and use. First, we identify the need for domain-specific recommendations against the context of current ELSI guidance. We then demonstrate the feasibility and usefulness of taking a domain-specific approach by successively transforming currently identified ELSI into an action-guiding flowchart for integration of ELSI specific to the different stages of WR development. This flowchart identifies specific questions to be considered by WR development teams and suggests actions to be taken in response. By tailoring ELSI guidance to WR developers, centring it on user needs, their relation to others and wider society, and being cognizant of existing legislation and values, we hope to help the community develop better WRs that are safer, have greater usability, and which impact positively on society.
Effects of Steel Fiber Percentage and Aspect Ratios on Fresh and Harden Properties of Ultra-High Performance Fiber Reinforced Concrete
Authors: Biswas Rajib Kumar , Bin Ahmed Farabi , Haque Md. Ehsanul , Provasha Afra Anam , Hasan Zahid , Hayat Faria , Sen Debasish
Published: July 2021

Steel fibers and their aspect ratios are important parameters that have significant influence on the mechanical properties of ultrahigh-performance fiber-reinforced concrete (UHPFRC). Steel fiber dosage also significantly contributes to the initial manufacturing cost of UHPFRC. This study presents a comprehensive literature review of the effects of steel fiber percentages and aspect ratios on the setting time, workability, and mechanical properties of UHPFRC. It was evident that (1) an increase in steel fiber dosage and aspect ratio negatively impacted workability, owing to the interlocking between fibers; (2) compressive strength was positively influenced by the steel fiber dosage and aspect ratio; and (3) a faster loading rate significantly improved the mechanical properties. There were also some shortcomings in the measurement method for setting time. Lastly, this research highlights current issues for future research. The findings of the study are useful for practicing engineers to understand the distinctive characteristics of UHPFRC.
Routing Performance Evaluation of a Multi-Domain Hybrid SDN for Its Implementation in Carrier Grade ISP Networks
Authors: Dawadi Babu , Thapa Abhishek , Guragain Roshan , Karki Dilochan , Upadhaya Sandesh , Joshi Shashidhar
Published: July 2021

Legacy IPv4 networks are strenuous to manage and operate. Network operators are in need of minimizing the capital and operational expenditure of running network infrastructure. The implementation of software-defined networking (SDN) addresses those issues by minimizing the expenditures in the long run. Legacy networks need to integrate with the SDN networks for smooth migration towards the fully functional SDN environment. In this paper, we compare the network performance of the legacy network with the SDN network for IP routing in order to determine the feasibility of the SDN deployment in the Internet Service provider (ISP) network. The simulation of the network is performed in the Mininet test-bed and the network traffic is generated using a distributed Internet traffic generator. An open network operating system is used as a controller for the SDN network, in which the SDN-IP application is used for IP routing. Round trip time, bandwidth, and packet transmission rate from both SDN and legacy networks are first collected and then the comparison is made. We found that SDN-IP performs better in terms of bandwidth and latency as compared to legacy routing. The experimental analysis of interoperability between SDN and legacy networks shows that SDN implementation in a production level carrier-grade ISP network is viable and progressive.
Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation
Authors: Scheibe Christian , Karreman Christiaan , Schildknecht Stefan , Leist Marcel , Hauser Karin
Published: July 2021

The 140 amino acid protein α-synuclein (αS) is an intrinsically disordered protein (IDP) with various roles and locations in healthy neurons that plays a key role in Parkinson’s disease (PD). Contact with biomembranes can lead to α-helical conformations, but can also act as s seeding event for aggregation and a predominant β-sheet conformation. In PD patients, αS is found to aggregate in various fibrillary structures, and the shift in aggregation and localization is associated with disease progression. Besides full-length αS, several related polypeptides are present in neurons. The role of many αS-related proteins in the aggregation of αS itself is not fully understood Two of these potential aggregation modifiers are the αS splicing variant αS Δexon3 (Δ3) and the paralog β-synuclein (βS). Here, polarized ATR-FTIR spectroscopy was used to study the membrane interaction of these proteins individually and in various combinations. The method allowed a continuous monitoring of both the lipid structure of biomimetic membranes and the aggregation state of αS and related proteins. The use of polarized light also revealed the orientation of secondary structure elements. While αS led to a destruction of the lipid membrane upon membrane-catalyzed aggregation, βS and Δ3 aggregated significantly less, and they did not harm the membrane. Moreover, the latter proteins reduced the membrane damage triggered by αS. There were no major differences in the membrane interaction for the different synuclein variants. In combination, these observations suggest that the formation of particular protein aggregates is the major driving force for αS-driven membrane damage. The misbalance of αS, βS, and Δ3 might therefore play a crucial role in neurodegenerative disease.
Chronic DDE Exposure Modifies Mitochondrial Respiration during Differentiation of Human Adipose-Derived Mesenchymal Stem Cells into Mature Adipocytes
Authors: Kladnicka Iva , Cedikova Miroslava , Jedlicka Jan , Kohoutova Michaela , Muller Ludek , Plavinova Iveta , Kripnerova Michaela , Bludovska Monika , Kuncova Jitka , Mullerova Dana
Published: July 2021

The contribution of environmental pollutants to the obesity pandemic is still not yet fully recognized. Elucidating possible cellular and molecular mechanisms of their effects is of high importance. Our study aimed to evaluate the effect of chronic, 21-day-long, 2,2-bis (4-chlorophenyl)-1,1-dichlorethylenedichlorodiphenyldichloroethylene (p,p′-DDE) exposure of human adipose-derived mesenchymal stem cells committed to adipogenesis on mitochondrial oxygen consumption on days 4, 10, and 21. In addition, the mitochondrial membrane potential (MMP), the quality of the mitochondrial network, and lipid accumulation in maturing cells were evaluated. Compared to control differentiating adipocytes, exposure to p,p′-DDE at 1 μM concentration significantly increased basal (routine) mitochondrial respiration, ATP-linked oxygen consumption and MMP of intact cells on day 21 of adipogenesis. In contrast, higher pollutant concentration seemed to slow down the gradual increase in ATP-linked oxygen consumption typical for normal adipogenesis. Organochlorine p,p′-DDE did not alter citrate synthase activity. In conclusion, in vitro 1 μM p,p′-DDE corresponding to human exposure is able to increase the mitochondrial respiration per individual mitochondrion at the end of adipocyte maturation. Our data reveal that long-lasting exposure to p,p′-DDE could interfere with the metabolic programming of mature adipocytes.
Environmentally Friendly Nafion-Catalyzed Synthesis of Substituted 2-Ethyl-3-Methylquinolines from Aniline and Propionaldehyde under Microwave Irradiation
Authors: Chan Chieh-Kai , Lai Chien-Yu , Wang Cheng-Chung
Published: July 2021

Herein, we report a facile synthetic methodology for the preparation of 2,3-dialkylquinolines from anilines and propionaldehydes. This cyclization involved environmentally friendly Nafion® NR50 as an acidic catalyst with microwave irradiation as the heating source. A series of substituted 2-ethyl-3-methylquinolines were prepared from various anilines and propionaldehyde derivatives through this protocol with good to excellent yields. Some new chemical structures were confirmed by X-ray single-crystal diffraction analysis and the related data were provided. The plausible reaction mechanism studies are also discussed.
Impact of Primary and Secondary ZDDP and Ionic Liquid as Lubricant Oil Additives on the Performance and Physicochemical Properties of Pd-Based Three-Way Catalysts
Authors: Kim Daekun , Toops Todd J. , Nguyen Ke , Lance Michael J. , Qu Jun
Published: July 2021

In the present study, two industry primary and secondary zinc dialkyldithiophosphate standards, ZDDP1 and ZDDP2, respectively, are evaluated for their impact on the performance of Pd-based three-way catalyst and bench-marked against two mixed lubricant additives formed from either ZDDP1 or ZDDP2 with a second-generation oil-miscible phosphoric-containing ionic liquid (IL). The three-way catalysts (TWCs) are exposed to the lubricant additives in an engine bench under four different scenarios: a base case with no additive (NA), ZDDP1, IL+ZDDP1, ZDDP2, and IL+ZDDP2. The engine-aged TWC samples are characterized through a variety of analytical techniques, including evaluation of catalyst reactivity in a bench-flow reactor. With respect to the water–gas shift reaction and the oxygen storage capacity, the ZDDP2- and IL+ZDDP2-aged TWC samples are more degraded than the ZDDP1- and IL+ZDDP1-aged TWC samples. X-ray diffraction (XRD) patterns indicate that phosphorus in the form of CePO4 was found to be present in the washcoat of all TWC samples, with the highest amount found in the ZDDP2-aged TWC sample. The results obtained from XRD are further confirmed by those from inductively coupled plasma-optical emission spectroscopy (ICP-OES), which show that more phosphorus is detected in the washcoat of ZDDP2- and IL+ZDDP2-aged TWC samples than in the ZDDP1- and IL+ZDDP1-aged TWC samples.
Crystallization Kinetics of α-Hemihydrate Gypsum Prepared by Hydrothermal Method in Atmospheric Salt Solution Medium
Authors: Wei Zhongqi , Zhang Qin , Li Xianbo
Published: July 2021

α-Calcium sulfate hemihydrate (α-HH) is an important cementitious material, which can be prepared by hydrothermal method from calcium sulfate dihydrate (DH) in an electrolyte solution. Study of the conversion kinetics of DH to α-HH in NaCl solution is helpful for understanding the control process. In this paper, X-ray diffraction (XRD) patterns were applied to study the effect of temperature on the crystallization kinetics of α-HH to determine the kinetic parameters. The research results show that the sigmoidal shape of the α-HH crystallization curve follows the Avrami-Erofeev model, which describes the crystallization kinetics of α-HH formation. Applying Arrhenius law in experimental data and model calculations, an apparent activation energy of 124 kJ/mol for nucleation and an apparent activation energy of 810 kJ/mol for growth were obtained. By adjusting the temperature of the solution, the number of α-HH nucleation and growth steps increases, which can effectively increase the DH-α-HH conversion rate in the NaCI solution.
Update on Superficial Spindle Cell Mesenchymal Tumors in Children
Authors: Drabent Philippe , Fraitag Sylvie
Published: July 2021

The diagnosis of cutaneous and subcutaneous spindle cell neoplasms in children is often challenging and has potential therapeutic and prognostic implications. Although correctly diagnosing dermatofibrosarcoma protuberans and infantile fibrosarcoma is paramount, pathologists should not ignore a number of diagnostic pitfalls linked to mostly rare tumors with completely different clinical outcomes. In the last decade, a spectrum of novel entities has been described; information from molecular biology has helped to shape this new landscape for spindle cell tumors. Here, we review the most noteworthy neoplasms in this spectrum, with a focus on their histological similarities: fibroblastic connective tissue nevus, medallion-like dermal dendrocyte hamartoma, or plaque-like CD34-positive dermal fibroma, which share features with fibrous hamartoma of infancy; lipofibromatosis and lipofibromatosis-like neural tumor; and plexiform myofibroblastoma, a recently described neoplasm that should be distinguished from plexiform fibrohistiocytic tumor. These tumors also have genetic similarities, particularly gene rearrangements involving NTRK3 or NTRK1. These genetic features are not only essential for the differential diagnosis of infantile fibrosarcoma but are also of diagnostic value for lipofibromatosis-like neural tumors. The more recently described RET, RAF1, and BRAF gene fusions are also discussed.
Assessment of Potential Risk Factors and Skin Ultrasound Presentation Associated with Breast Cancer-Related Lymphedema in Long-Term Breast Cancer Survivors
Authors: Yusof Khairunnisa’ Md , Avery-Kiejda Kelly A. , Ahmad Suhaimi Shafinah , Ahmad Zamri Najwa , Rusli Muhammad Ehsan Fitri , Mahmud Rozi , Saini Suraini Mohd , Abdul Wahhab Ibraheem Shahad , Abdullah Maha , Rosli Rozita
Published: July 2021

Breast cancer has been reported to have the highest survival rate among various cancers. However, breast cancer survivors face several challenges following breast cancer treatment including breast cancer-related lymphedema (BCRL), sexual dysfunction, and psychological distress. This study aimed to investigate the potential risk factors of BCRL in long term breast cancer survivors. A total of 160 female breast cancer subjects were recruited on a voluntary basis and arm lymphedema was assessed through self-reporting of diagnosis, arm circumference measurement, and ultrasound examination. A total of 33/160 or 20.5% of the women developed BCRL with significantly higher scores for upper extremity disability (37.14 ± 18.90 vs. 20.08 ± 15.29, p < 0.001) and a lower score for quality of life (103.91 ± 21.80 vs. 115.49 ± 16.80, p = 0.009) as compared to non-lymphedema cases. Univariate analysis revealed that multiple surgeries (OR = 5.70, 95% CI: 1.21–26.8, p < 0.001), axillary lymph nodes excision (>10) (OR = 2.83, 95% CI: 0.94–8.11, p = 0.047), being overweight (≥25 kg/m2) (OR = 2.57, 95% CI: 1.04 – 6.38, p = 0.036), received fewer post-surgery rehabilitation treatment (OR = 2.37, 95% CI: 1.05–5.39, p = 0.036) and hypertension (OR = 2.38, 95% CI: 1.01–5.62, p = 0.043) were associated with an increased risk of BCRL. Meanwhile, multivariate analysis showed that multiple surgeries remained significant and elevated the likelihood of BCRL (OR = 5.83, 95% CI: 1.14–29.78, p = 0.034). Arm swelling was more prominent in the forearm area demonstrated by the highest difference of arm circumference measurement when compared to the upper arm (2.07 ± 2.48 vs. 1.34 ± 1.91 cm, p < 0.001). The total of skinfold thickness of the affected forearm was also significantly higher than the unaffected arms (p < 0.05) as evidenced by the ultrasound examination. The continuous search for risk factors in specific populations may facilitate the development of a standardized method to reduce the occurrence of BCRL and provide better management for breast cancer patients.