bluuebunny/crossref_metadata_2025 huggingface dataset:
The Nephroprotective Effects of Pomegranate Juice against Lithium-Induced Kidney Damage in Rats
Authors: Sedighi Masoud , Jamshidi Hamid Reza
Published: May 2024

Background: This study aims to investigate the effect of pomegranate juice on kidney damage caused by lithium in rats. Methods: Six groups of animals were studied, group one received neither lithium nor pomegranate juice, group two received only lithium, group three received only pomegranate juice, and groups four to six received both lithium and pomegranate juice at different doses. Kidney biomarkers were investigated as indicators of acute kidney failure. Results: Comparison between the studied groups regarding the amount of creatinine in the serum of rats showed a significant relationship between serum creatinine levels of rats in the group receiving lithium and the control group, and the group receiving lithium and those receiving pomegranate juice at a dose of 100 mg/kg. A significant relationship was observed in the study of serum urea amount in rats between the control group and the group receiving lithium, and the lithium group and the group receiving pomegranate juice at a dose of 100 mg/kg. Conclusions There was no significant difference between the groups when the amount of cystatin C in the serum of rats was compared. Pomegranate juice at 100 mg/kg and lithium (25mg/kg) led to a significant decrease in serum creatinine levels, which reduced kidney damage induced by lithium. Serum urea also decreased significantly, suggesting that pomegranate has anti-toxic effects on kidneys from lithium toxicity
Food Insecurity regarding the Diabetes Mellitus in Iran: A Systematic Review and Meta-Analysis
Authors: Maddahi Mona , Asadimehr Soheil , Ahmadi Amirhossein Ramezani , Kakhki Fatemeh Govahi , Sobhani Seyyed Reza
Published: May 2024

Background: Food insecurity is an important global challenge associated with various health problems such as diabetes. Diabetes mellitus is one of the most common metabolic diseases and is considered priority in Iran’s health system. The aim of this study is to evaluate the relationship between food insecurity and type 2 dibetes mellitus (T2DM) in Iran. Methods: The authors searched English databases including Scopus, Web of Science, PubMed, and Google Scholar and also Iranian databasesof SID and Magiran for the words food insecurity, Iran, and diabetes up to November 2021. Results: 8 articles, including 2853 participants, ranging from 148 to 440 were included in the meta-analysis. The pooled odds ratios (ORs) of the cross-sectional  and  case-control studies revealed that household food insecurity was significantly associated with the odds of diabetes (OR=2.04; 95% CI: 1.34- 3.09) and there was no evidence for publication bias (Egger’s test, P = 0.59); however, heterogeneity between studies (I2=85.9%) was observed. Similarly, according to subgroup analyses based on age, there was a significant association between household food insecurity and diabetes among the people under 50 years (OR= 2.9; 95% CI: 2.13-3.93; I2 = 56.4%, P=0.057), but not among people over 50 years (OR=1.32; 95% CI: 0.69-2.52; I2 = 78.3%, P=0.032) or between 30 and 65 years (OR=0.85; 95% CI: 0.49-1.48). Conclusion: This study shows that food insecurity affects the progression of type 2 DM. However, more longitudinal studies are needed for better identification of the link between food insecurity and T2DM.
Paisagens, percepções e composições para outros processos de formação
Authors: Roemers  Moacyr Juliana , Guardiola  Lunardi Adriana , Hoepers Preve Ana  Maria
Published: May 2024

O que percebemos ao nosso redor e como o percebemos? O que está para além daquilo que enxergamos? Como revelar outras paisagens na paisagem? Essas questões motivaram a elaboração de uma oficina no Programa de Educação Ambiental do Parque Estadual da Serra do Tabuleiro. A oficina Paisagens, percepções e composições buscou pôr à mostra paisagens percebidas, lembradas e imaginadas, misturando memória e afetividade com a força dos pigmentos naturais das plantas e da terra. Na tentativa de afastar se de uma educação dada a priori, a intenção foi produzir uma ruptura, para ultrapassar a linha de uma educação ambiental institucionalizada tida como garantia de conscientização para a conservação da natureza, para, na sequência, pensá-la por outras vias. No trabalho com essa oficina investimos em uma experimentação com a educação ambiental tornando-a inventiva. Como inventiva consideramos uma educação que está implicada com uma poética e uma política das sutilezas para que então pudéssemos imaginar outras naturezas, outras paisagens, outras formas de relação e proteção e por sua vez de percepção no espaço de uma Unidade de Conservação.
As geografias em Torto Arado e as aproximações com a formação de professoras e professores
Authors: Perretto de Andrade Luan , Rousseng Dal Pont Karina
Published: May 2024

O livro “Torto Arado” de Itamar Vieira Júnior, publicado em 2019, é o objeto de estudo desta pesquisa, assim como a formação de professores e professoras de geografia e o uso das diferentes linguagens na educação geográfica. A pesquisa visou investigar as geografias presentes no livro, e estimular a aplicação da Lei 10.639/2003 pela presença de aspectos culturais afro-brasileiras no romance. Nos aproximamos de autoras como Djamila Ribeiro e Sueli Carneiro para refletir sobre as potencialidades do "letramento racial" na educação geográfica, e a discussão sobre o conceito de lugar em Y-Fu Tuan. Com esse intuito houve a organização, realização e análise de uma oficina pedagógica com estudantes do Curso de Geografia da UUUU. Na oficina utilizamos trechos do romance, imagens da tese de doutorado de Itamar Vieira Junior, e da artista Linoca Souza, bem como técnicas de produção de gravuras no intuito de mobilizar as "imaginações geográficas" à luz do pensamento de Doreen Massey. Com essa pesquisa buscou-se evidenciar a produção de escritores, escritoras e artistas pretas(os) e introduzir a cultura afro-brasileira na formação de educadoras e educadores dentro universidade com reflexos para a docência nas escolas, potencializando outras miradas para educação geográfica neste encontro com a literatura e a arte.
Intensification of the Biohydrogen Production Process
Authors: Golub Nataliia , Zubchenko Liudmyla , Demianenko Iryna , Zhang Yumei , Seminska Nataliia
Published: May 2024

Background. In the last decades, humanity has faced the challenge of finding new ways to obtain renewable, environmentally friendly energy carriers. Hydrogen is one of such energy carriers; however, the current methods of its production require fossil fuels and are accompanied by significant CO2 emissions. Consequently, the energy costs needed to obtain hydrogen by electrolysis exceed the amount of energy produced by burning the hydrogen. Simultaneously, the hydrogen yields for alternative ways, such as fermentation, remain low.
Objective. The aim of the work is the development of approaches to intensify the biohydrogen obtaining process from agricultural waste.
Methods. An increase in hydrogen yield was achieved using specifically grown microorganisms of the Clostridium spp. A combination of the waste fermentation process with the production of hydrogen in a microbial fuel cell (MFC), which was fed with the liquid fraction after fermentation, was employed.
Results. The yield of hydrogen depends on the component composition of the raw material. Higher lignin content in the raw material reduces the yield of hydrogen. The addition of Clostridium spp. to the natural consortium in the amount of 10% of the total inoculum led to an increase in hydrogen yield. The combination of two processes – fermentation and hydrogen production in a MFC – increased the yield of hydrogen by 1.7 times, along with a higher degree of organic raw materials utilization.
Conclusions. The additional introduction of Clostridium spp. to the hydrogen-producing consortium leads to a 7–10% increase in the yield of hydrogen, depending on the composition of the raw material. The yield of hydrogen obtained in the fermentation process for the substrate containing corn silage is 12 ± 1% higher than for the wheat straw. In general, the combination of the fermentation and hydrogen production in the MFC in a two-stage process leads to an overall increase in the yield of hydrogen by 60 ± 5%.
FOUCAULT, A IDADE CLÁSSICA E A MÁTHÊSIS UNIVERSALIS
Authors: Candiotto Cesar
Published: May 2024

O objetivo deste artigo consiste em aprofundar a intuição foucaultiana no livro As palavras e as coisas a respeito da máthêsis universalis como ciência geral da ordem e da medida, para tratar da Idade Clássica. Essa caracterização de Michel Foucault lhe permite afastar-se da percepção desta época pela lente do racionalismo, mecanicismo e matematização da natureza. Ao refletir sobre a ordem empírica dos seres, palavras e coisas pela relação entre máthêsis, taxinomia e teoria do signo, Foucault relativiza também certa percepção da fenomenologia (husserliana) segundo a qual o racionalismo seria o solo fundante da Modernidade.
Palavras-chave: Máthêsis. Taxinomia. Arqueologia. Fenomenologia. Michel Foucault. Descartes.
Analysis of Natural Dye Batik Waste Management in Ciwaringin Village that is Integrated into Science Learning in Elementary Schools as an SDGs Program
Authors: Margareth Niniss , Tresnawati Nailah , Permana Putri Dian
Published: May 2024

Batik is a cultural heritage of Indonesia, this is recognized by UNESCO that batik is an Indonesian culture that must be preserved. But in reality, the development of the batik industry is inversely proportional, Impact on the environment where the batik industry uses a lot of synthetic dyes, which have a negative impact on the surrounding aquatic environment. The purpose of this research is to analyze the process of processing batik waste using natural dyes carried out by batik craftsmen in Ciwaringin village then the natural dye process can be integrated in science learning in elementary schools as one of the SDGs programs that utilize local potential and improve environmental conservation in the surrounding environment so that the waste produced does not damage the environment. The research method used is descriptive qualitative method, where data collection uses interviews, observation and documentation. Data analysis was carried out with three main stages, namely data collection through exploration, data reduction, analysis, and integration in science learning in elementary schools. The results showed that the analysis of waste treatment starting from the process of making natural dyes, the process of making batik and the results of coloring the resulting waste is very low in residual waste so that batik products using natural dyes can be analyzed in terms of local wisdom that can be integrated in science learning in elementary schools, this can be used as an SDGs program in elementary schools that has a positive impact on the environment. The implication of this research is an effort to implement education to create local wisdom and environmental preservation and stimulate student creativity in creating art products that have SDGs sustainability values.
Portraying Teacher Performance Management in Schools Implementing Semester Credit System
Authors: Mardianti Desi , Bambang Budi Wiyono  , Ali Imron  , Ery Tri Djatmika
Published: May 2024

The purpose of this study is to reveal the management of teacher performance management in schools that implement the Semester Credit System (SKS). This study uses a qualitative approach with a multi-site study design, using in-depth interviews, observation, and study of documents in collecting data. Data analysis was carried out in stages. The results showed that teacher performance planning in schools that manage the SKS program includes planning for the needs of the SKS program (needs for materials, facilities, infrastructure, and program facilities as well as the program implementing team), learning planning in the SKS program, planning for placement in the SKS class, planning for mentoring and academic guidance, training planning, capacity building, and budget planning for the SKS program. Second, the implementation of teacher performance is carried out by (a) preparing the needs of the SKS program by forming a team for developing the SKS program curriculum and making SKS program guidelines. The team is chaired by the principal, the waka of the curriculum as program coordinator, and teachers as team members. The team is tasked with preparing program guides, providing academic advisors, creating curriculum structures, determining learning loads, and recommending the number of credits to students. (b) academic tests, psychology, grades V and VI report cards, UN scores for consideration. Placing students in the SKS class in the first semester and determining the SKS program students in the second semester. Provide KRS. (c) Provide academic services in the form of academic guidance, teachers become academic advisors, provide study plan cards (KRS), help students determine credits, make learning tools, analyze student development, and socialize the development of student learning outcomes. (d) making lesson plans, making other teaching tools through the MGMP forum, preparing teaching materials, teaching processes, and teaching assessments. Third, teacher performance evaluation is carried out by the principal on an ongoing basis. Evaluation is carried out through meetings (meetings), briefings, and supervision. Supervision using a format that already exists and is available at school.
Cycle Model Of Integrative-Interconnective Strategy within Character Learning
Authors: Anam Nurul , Degeng I Nyoman Sudana , Kuswandi Dedi , Sulton
Published: May 2024

Received: Revised: Accepted: This paper describes the cycle model of integrative-interactive character learning strategies at ‘MTs’ (Islamic Junior High School) Islamic Boarding School. The data is focused on MTs Al-Qodiri 1 and Nuris 1 Jember. This study used a qualitative approach having a multi-site research principle. The findings of this study showed that the application of the cycle model of integrative-interactive character learning strategies in MTs Islamic Boarding School has its own characteristics and can be considered to be a successful model of student character development. Character learning materials, especially the character values are the integration of values within the formal curriculum and Sufi based Islamic Boarding School typical curriculum. The materials are organized through the process of determining the material, structuring the order, constructing analogy, and summarizing the contents of character learning. Various interactive, collaborative and learning media are used, so that the transfer process of character learning material is easily understood and practiced in daily life. In order to ensure that the organization and the process of learning provision are more optimal, the character learning regulation is carried out by a 24-hour scheduling process followed by a continuous process of monitoring, motivational management, and supervision.
Effects of Abaloparatide on Bone Mineral Density in Proximal Femoral Regions Corresponding to Arthroplasty Gruen Zones
Authors: Sheth Neil P. , Smith James Russell , Winzenrieth Renaud , Humbert Ludovic , Wang Yamei , Boxberger John I. , Bostrom Mathias P.
Published: May 2024

Background:

Low hip bone mineral density (BMD) in patients who undergo total hip arthroplasty (THA) increases the risk of periprosthetic fractures, implant instability, and other complications. Recently, emphasis has been placed on bone health optimization: treating low BMD prior to a planned orthopaedic implant procedure in an effort to normalize BMD and reduce the potential risk of future complications. Abaloparatide is a U.S. Food and Drug Administration-approved osteoanabolic agent for men and postmenopausal women with osteoporosis and a candidate drug for bone health optimization that, in addition to benefits at the spine, increases hip BMD and reduces nonvertebral fracture risk. We hypothesized that abaloparatide would improve BMD in proximal femoral regions surrounding a virtual THA stem.

Methods:

This post hoc analysis obtained dual x-ray absorptiometry (DXA) hip scans from 500 randomly selected postmenopausal women with osteoporosis from the Phase-3 Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE, NCT01343004) study after 0, 6, and 18 months of abaloparatide (250 patients) or placebo (250 patients). Hip DXA scans underwent 3-dimensional (3D) modeling via 3D-Shaper, followed by virtual resection of the proximal femur and simulated placement of a tapered, flat-wedge hip stem that guided delineation of the Gruen zones that were fully (zones 1 and 7) or largely (zones 2 and 6) captured in the scanning region. Integral, cortical, and trabecular volumetric BMD, cortical thickness, and cortical surface BMD (the product of cortical volumetric BMD and cortical thickness) were determined for each zone.

Results:

Compared with placebo, the abaloparatide group showed greater increases in integral volumetric BMD in all zones at months 6 and 18; cortical surface BMD in zones 1, 6, and 7 at month 6; cortical thickness, cortical volumetric BMD, and cortical surface BMD in all zones at month 18; and trabecular volumetric BMD in zones 1 and 7 at months 6 and 18.

Conclusions:

Abaloparatide increases BMD in proximal femoral regions that interact with and support femoral stems, suggesting that abaloparatide may have value for preoperative or potentially perioperative bone health optimization in patients with osteoporosis undergoing THA.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
The Margins at the Centre: New Light on Paris, Bibliothèque nationale de France, Arabe 2967
Authors: Pimpinelli Matteo
Published: May 2024

Marginal elements within manuscripts, especially when unsystematic, disorganised, and heterogenous, are often ignored by scholars who intentionally decide to prioritise the centre over the margins. Accordingly, the lion’s share of printed and online catalogues addresses the margins en passant. But to what extent is this approach fruitful to a comprehensive study of manuscripts? By focusing exclusively on margins, this article proposes to demonstrate that marginal annotations are instrumental in providing an exhaustive study of manuscripts in terms of historical reconstruction, and with regard to the annotators’ life, interests, and expertise. The interdisciplinarity of the study of margins stands out inasmuch as it mixes first-hand palaeographical and codicological examinations with a scrutinization of the sources. Specifically, the history of Paris, Bibliothèque nationale de France, Arabe 2967 will be unveiled with regard to the major events and people connected to it.
La Méditerranée chez Paul Valéry: De l’épiphanie marine à l’humanisme méditerranéen
Authors: Izzo Sara
Published: May 2024

L’objectif de cet article est de situer la vision méditerranée de Paul Valéry dans le discours intellectuel de l’entre-deux-guerres. Dans cette optique, nous nous proposons de dégager les différentes couches sémantiques associées au concept de Méditerranée au sein de l’œuvre valéryenne, à savoir sa signification sensorielle, intellectuelle et socioculturelle. Bien que sur le plan sensoriel et intellectuel, elle présente des similitudes avec la pensée méditerranéenne des auteurs de l’École d’Alger, la conception méditerranéenne de Valéry se distingue de la leur par ses idées socioculturelles. Celles-ci sont élaborées sur la base d’une lecture attentive (close reading) de ses essais écrits après la Première Guerre mondiale, afin de les situer dans le discours méditerranéen de l’entre-deux-guerres.
Lesley Smith, Fragments of a World: William of Auvergne and His Medieval Life, The University of Chicago Press, Chicago 2023, 312 pp., ISBN: ‎9780226826189.
Authors: Kreeger Seth
Published: May 2024

Review of:
Lesley Smith, Fragments of a World: William of Auvergne and His Medieval Life, The University of Chicago Press, Chicago 2023, 312 pp., ISBN: ‎9780226826189.
Data-driven modeling of groundwater level using machine learning
Authors: Dutta Sourav , Wagner Anna , Hall Theadora , Pradhan Nawa Raj
Published: May 2024

This US Army Engineer Research and Development Center (ERDC), Coastal and Hydraulics Laboratory engineering technical note (CHETN) documents a preliminary study on the use of specialized machine learning (ML) methods to model the variations in groundwater level (GWL) with time. This approach uses historical groundwater observation data at seven gage locations in Wyoming, USA, available from the USGS database and historical data on several relevant meteorological variables obtained from the ERA5 reanalysis dataset produced by the Copernicus Climate Change Service (usually referred to as C3S) at the European Center for Medium-Range Weather Forecasts to predict future GWL values for a desired period of time. The results presented in this report indicate that the ML method has the potential to predict both short-term (4-hourly) as well as daily variations in GWL several days into the future for the chosen study region, thus alleviating the need for employing sophisticated process-based numerical models with complicated model structure configurations.
Storynomic Tourism Strategy of Kebo Ketan Ceremonial Art as a Form of Marketing Communication for Eco-Tourism
Authors: Parani Rizaldi , Hubner Ira Brunchilda , Juliana Juliana , Purba Herman
Published: May 2024

Kebo Ketan celebration held in Sekaralas village, Ngawi by Kraton Ngiyom non-governmental organization (NGO). The myth contained in this ceremonial art is a narrative related to concern for the culture, ecology and economy of the Sekaralas village community. This ceremonial art presenting a giant statue of a water buffalo and symbolic objects such as sticky rice, brown sugar, and musical instruments as well as sacred dances. The aim of this ceremonial art is to convey messages related to preserving the natural environment around the Sekaralas village area, and encouraging increased social cohesiveness of village residents. This research intends to describe and analyze how the storynomic tourism strategy is used through the Kebo Ketan ceremonial art as a form of marketing communication for eco-tourism in Sekaralas village, which can depict the power of culture through myths and rituals, packaged in a narrative form to attract tourists. This research used qualitative approach, with the ethnographic method. Primary data were collected through semi-structured interviews with five informants and also complemented by observation results. The research results show that storynomics has the potential to encourage eco-tourism in Sekaralas village, which can be done mainly through the use of digital media. However, the village residents have not fully understood the meaning of the messages conveyed through the Kebo Ketan ceremonial art, especially regarding environmental conservation and the encouragement to develop the village.
RETRACTED: Urbanization and Plant Diversity in Residential Gardens: a Case Study in Rize, Turkey
Authors: DOĞAN Tuba Gül , DEMİRCİ Sena , EROĞLU Engin , KAYA Sertaç , MERAL Alperen , BAŞARAN Nermin
Published: May 2024

The authors have requested that this preprint be removed from Research Square.
Proximity-induced gapless superconductivity in two-dimensional Rashba semiconductor in magnetic field
Authors: Babkin Serafim S. , Higginbotham Andrew P. , Serbyn Maksym
Published: May 2024

Two-dimensional semiconductor-superconductor heterostructures form the foundation of numerous nanoscale physical systems. However, measuring the properties of such heterostructures, and characterizing the semiconductor in-situ is challenging. A recent experimental study by [Phys. Rev. Lett. 128, 107701 (2022)] was able to probe the semiconductor within the heterostructure using microwave measurements of the superfluid density. This work revealed a rapid depletion of superfluid density in semiconductor, caused by the in-plane magnetic field which in presence of spin-orbit coupling creates so-called Bogoliubov Fermi surfaces. The experimental work used a simplified theoretical model that neglected the presence of non-magnetic disorder in the semiconductor, hence describing the data only qualitatively. Motivated by experiments, we introduce a theoretical model describing a disordered semiconductor with strong spin-orbit coupling that is proximitized by a superconductor. Our model provides specific predictions for the density of states and superfluid density. Presence of disorder leads to the emergence of a gapless superconducting phase, that may be viewed as a manifestation of Bogoliubov Fermi surface. When applied to real experimental data, our model showcases excellent quantitative agreement, enabling the extraction of material parameters such as mean free path and mobility, and estimating gg-tensor after taking into account the orbital contribution of magnetic field. Our model can be used to probe in-situ parameters of other superconductor-semiconductor heterostructures and can be further extended to give access to transport properties.
Weakly interacting Bose gas with two-body losses
Authors: Liu Chang , Shi Zheyu , Wang Ce
Published: May 2024

We study the many-body dynamics of weakly interacting Bose gases with two-particle losses. We show that both the two-body interactions and losses in atomic gases may be tuned by controlling the inelastic scattering process between atoms by an optical Feshbach resonance. Interestingly, the low-energy behavior of the scattering amplitude is governed by a single parameter, i.e. the complex ss-wave scattering length a_cac. The many-body dynamics are thus described by a Lindblad master equation with complex scattering length. We solve this equation by applying the Bogoliubov approximation in analogy to the closed systems. Various peculiar dynamical properties are discovered, some of them may be regarded as the dissipative counterparts of the celebrated results in closed Bose gases. For example, we show that the next-order correction to the mean-field particle decay rate is to the order of |n a_c^{3}|^{1/2}|nac3|1/2, which is an analogy of the Lee-Huang-Yang correction of Bose gases. It is also found that there exists a dynamical symmetry of symplectic group Sp(4,\mathbb{C})(4,ℂ) in the quadratic Bogoliubov master equation, which is an analogy of the SU(1,1) dynamical symmetry of the corresponding closed system. We further confirmed the validity of the Bogoliubov approximation by comparing its results with a full numerical calculation in a double-well toy model. Generalizations of other alternative approaches such as the dissipative version of the Gross-Pitaevskii equation and hydrodynamic theory are also discussed in the last.
Floquet engineering of axion and high-Chern number phases in a topological insulator under illumination
Authors: Shafiei Mohammad , Fazileh Farhad , Peeters François Maria , Milošević Milorad V.
Published: May 2024

Quantum anomalous Hall, high-Chern number, and axion phases in topological insulators are characterized by its Chern invariant C (respectively, C=1, integer C>1, and C=0 with half-quantized Hall conductance of opposite signs on top and bottom surfaces). They are of recent interest because of novel fundamental physics and prospective applications, but identifying and controlling these phases has been challenging in practice. Here we show that these states can be created and switched between in thin films of Bi_22Se_33 by Floquet engineering, using irradiation by circularly polarized light. We present the calculated phase diagrams of encountered topological phases in Bi_22Se_33, as a function of wavelength and amplitude of light, as well as sample thickness, after properly taking into account the penetration depth of light and the variation of the gap in the surface states. These findings open pathways towards energy-efficient optoelectronics, advanced sensing, quantum information processing and metrology.
Probing proton PDFs at high x with LHCb
Authors: Boettcher Thomas
Published: May 2024

LHCb is a forward spectrometer at the LHC covering the pseudorapidity region 2<\etaη<5. Because of this forward coverage, LHCb can probe the proton parton distribution functions (PDFs) in previously unexplored kinematic regimes, in particular at very high and low Bjorken-x. This contribution presents LHCb measurements that can be used to constrain the proton PDFs, with a focus on the high-x and high-Q^2Q2 regime.
CHARACTERISTICS OF NATA FROM CARICA (Carica Pubescens) EXTRACT WITH DIFFERENT CONCENTRATION OF ACETOBACTER XYLINUM AND FERMENTATION TIME
Authors:   Universitas PGRI Semarang, Suryanti Anik , Nurdyansyah Fafa ,   Universitas PGRI Semarang, Ujianti Rizky Muliani Dwi ,   Universitas PGRI Semarang, Muflihati Iffah ,   Universitas PGRI Semarang, Nurcholis Mochamad ,   Universitas Brawijaya
Published: May 2024

Nata de carica is a product of the innovation of fermentation of carica fruit (Carica pubescens) with the use of Acetobacter xylinum as a culture. The objective of this study was to analyze the impact of Acetobacter xylinum starter concentrations and fermentation time on the physical characteristics (chewiness, color, thickness, yield), chemical (crude fiber content, water content) and organoleptic (descriptive test) of nata de carica. The experimental design was used factorial design with two factors, Acetobacter xylinum starter concentration (10%, 15% and 20%) and fermentation time (7 days and 14 days). The results showed that there was a relationship between thickness, yield, chewiness and crude fiber, the thicker the nata, the greater the yield, chewiness and crude fiber. The best results of nata de carica treatment was treatment with 20% Acetobacter xylinum concentration and 14 days of fermentation time with a thickness value of 6.29 mm, a yield value of 41.04%, a texture value (efficiency) of 521.27 g/mm, crude fiber value of 1.05%, a color value of L* 50.36, a value of a*-1.87, a b* -3.93 and water content of 98.86%. The results of the research can be concluded that the starter concentration and the fermentation time influence the physical and chemical properties of the nata de carica produced.
La planeación pedagógica como herramienta para garantizar el desarrollo de prácticas educativas inclusivas desde un enfoque por competencias
Authors: Rojas – Zambrano Baldomiro , Silvera – Berdugo Miguel Ángel , Uribe – Ibarra Doris
Published: May 2024

Objetivo: Identificar las características de la planeación pedagógica y su relación con las prácticas educativas inclusivas desde un enfoque por competencias. Método: El estudio se rigió por métodos propios de la investigación cuantitativa, con un alcance descriptivo y con un enfoque bibliométrico, atendiendo a las orientaciones del método Prisma, revisando la literatura disponible en las bases de datos Scopus, Dialnet y Scielo, para lo cual se realizó la búsqueda de los documentos a través de una ecuación con operadores booleanos, y se definieron criterios de inclusión y exclusión, seleccionándose 48 artículos científicos entre los años 2014 y 2023. Resultados: Evidencian un aumento gradual de las producciones científicas relacionadas con el tema de estudio que coinciden con la implementación de lineamientos y políticas educativas a nivel global en aras de lograr los propósitos establecidos en los Objetivos de Desarrollo Sostenible. Se destaca el uso del paradigma cualitativo en las investigaciones que se vinculan con el objeto de estudio. Conclusiones: El análisis de la información recolectada permitió establecer que el enfoque por competencias constituye la oportunidad de dinamizar planeaciones pedagógicas pertinentes favoreciendo el desarrollo de prácticas educativas inclusivas que garanticen el respeto por la diversidad en el aula.
Deriving Treatment Decision Support From Dutch Electronic Health Records by Exploring the Applicability of a Precision Cohort–Based Procedure for Patients With Type 2 Diabetes Mellitus: Precision Cohort Study (Preprint)
Authors: Pinho Xavier , Meijer Willemijn , de Graaf Albert
Published: May 2024

BACKGROUND

The rapidly increasing availability of medical data in electronic health records (EHRs) may contribute to the concept of learning health systems, allowing for better personalized care. Type 2 diabetes mellitus was chosen as the use case in this study.

OBJECTIVE

This study aims to explore the applicability of a recently developed patient similarity–based analytics approach based on EHRs as a candidate data analytical decision support tool.

METHODS

A previously published precision cohort analytics workflow was adapted for the Dutch primary care setting using EHR data from the Nivel Primary Care Database. The workflow consisted of extracting patient data from the Nivel Primary Care Database to retrospectively generate decision points for treatment change, training a similarity model, generating a precision cohort of the most similar patients, and analyzing treatment options. This analysis showed the treatment options that led to a better outcome for the precision cohort in terms of clinical readouts for glycemic control.

RESULTS

Data from 11,490 registered patients diagnosed with type 2 diabetes mellitus were extracted from the database. Treatment-specific filter cohorts of patient groups were generated, and the effect of past treatment choices in these cohorts was assessed separately for glycated hemoglobin and fasting glucose as clinical outcome variables. Precision cohorts were generated for several individual patients from the filter cohorts. Treatment options and outcome analyses were technically well feasible but in general had a lack of statistical power to demonstrate statistical significance for treatment options with better outcomes.

CONCLUSIONS

The precision cohort analytics workflow was successfully adapted for the Dutch primary care setting, proving its potential for use as a learning health system component. Although the approach proved technically well feasible, data size limitations need to be overcome before application for clinical decision support becomes realistically possible.
Multicomponent Intervention to Improve Acute Myocardial Infarction Care in Tanzania: Protocol for a Pilot Implementation Trial (Preprint)
Authors: Hertz Julian T , Sakita Francis M , Rahim Faraan O , Mmbaga Blandina T , Shayo Frida , Kaboigora Vivian , Mtui Julius , Bloomfield Gerald S , Bosworth Hayden B , Bettger Janet P , Thielman Nathan M
Published: May 2024

BACKGROUND

Although the incidence of acute myocardial infarction (AMI) is rising in sub-Saharan Africa, the uptake of evidence-based care for the diagnosis and treatment of AMI is limited throughout the region. In Tanzania, studies have revealed common misdiagnosis of AMI, infrequent administration of aspirin, and high short-term mortality rates following AMI.

OBJECTIVE

This study aims to evaluate the implementation and efficacy outcomes of an intervention, the Multicomponent Intervention to Improve Acute Myocardial Infarction Care (MIMIC), which was developed to improve the delivery of evidence-based AMI care in Tanzania.

METHODS

This single-arm pilot trial will be conducted in the emergency department (ED) at a referral hospital in northern Tanzania. The MIMIC intervention will be implemented by the ED staff for 1 year. Approximately 400 adults presenting to the ED with possible AMI symptoms will be enrolled, and research assistants will observe their care. Thirty days later, a follow-up survey will be administered to assess mortality and medication use. The primary outcome will be the acceptability of the MIMIC intervention, which will be measured by the Acceptability of Intervention Measurement (AIM) instrument. Acceptability will further be assessed via in-depth interviews with key stakeholders. Secondary implementation outcomes will include feasibility and fidelity. Secondary efficacy outcomes will include the following: the proportion of participants who receive electrocardiogram and cardiac biomarker testing, the proportion of participants with AMI who receive aspirin, 30-day mortality among participants with AMI, and the proportion of participants with AMI taking aspirin 30 days following enrollment.

RESULTS

Implementation of MIMIC began on September 1, 2023. Enrollment is expected to be completed by September 1, 2024, and the first results are expected to be published by December 31, 2024.

CONCLUSIONS

This study will be the first to evaluate an intervention for improving AMI care in sub-Saharan Africa. If MIMIC is found to be acceptable, the findings from this study will inform a future cluster-randomized trial to assess effectiveness and scalability.

CLINICALTRIAL

ClinicalTrials.gov NCT04563546; https://clinicaltrials.gov/study/NCT04563546

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/59917
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