bluuebunny/crossref_metadata_2025 huggingface dataset:
Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes
Authors: He Panpan , Gan Xiaoqin , Wu Qimeng , Ye Ziliang , Yang Sisi , Zhang Yanjun , Li Huan , Zhou Chun , Zhang Yuanyuan , Liu Mengyi , Qin Xianhui
Published: September 2022

Background

We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes.

Methods

Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality.

Results

Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality).

Conclusion

VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality.
Application of cardiovascular 3-dimensional printing in Transcatheter aortic valve replacement
Authors: Ma Yanyan , Mao Yu , Zhu Guangyu , Yang Jian
Published: September 2022

Transcatheter aortic valve replacement (TAVR) has been performed for nearly 20 years, with reliable safety and efficacy in moderate- to high-risk patients with aortic stenosis or regurgitation, with the advantage of less trauma and better prognosis than traditional open surgery. However, because surgeons have not been able to obtain a full view of the aortic root, 3-dimensional printing has been used to reconstruct the aortic root so that they could clearly and intuitively understand the specific anatomical structure. In addition, the 3D printed model has been used for the in vitro simulation of the planned procedures to predict the potential complications of TAVR, the goal being to provide guidance to reasonably plan the procedure to achieve the best outcome. Postprocedural 3D printing can be used to understand the depth, shape, and distribution of the stent. Cardiovascular 3D printing has achieved remarkable results in TAVR and has a great potential.
Cost-effectiveness of strategies to control the spread of carbapenemase-producing Enterobacterales in hospitals: a modelling study
Authors: Kardaś-Słoma Lidia , Fournier Sandra , Dupont Jean-Claude , Rochaix Lise , Birgand Gabriel , Zahar Jean-Ralph , Lescure François-Xavier , Kernéis Solen , Durand-Zaleski Isabelle , Lucet Jean-Christophe
Published: September 2022

Background

Spread of resistant bacteria causes severe morbidity and mortality. Stringent control measures can be expensive and disrupt hospital organization. In the present study, we assessed the effectiveness and cost-effectiveness of control strategies to prevent the spread of Carbapenemase-producing Enterobacterales (CPE) in a general hospital ward (GW).

Methods

A dynamic, stochastic model simulated the transmission of CPE by the hands of healthcare workers (HCWs) and the environment in a hypothetical 25-bed GW. Input parameters were based on published data; we assumed the prevalence at admission of 0.1%. 12 strategies were compared to the baseline (no control) and combined different prevention and control interventions: targeted or universal screening at admission (TS or US), contact precautions (CP), isolation in a single room, dedicated nursing staff (DNS) for carriers and weekly screening of contact patients (WSC). Time horizon was one year. Outcomes were the number of CPE acquisitions, costs, and incremental cost-effectiveness ratios (ICER). A hospital perspective was adopted to estimate costs, which included laboratory costs, single room, contact precautions, staff time, i.e. infection control nurse and/or dedicated nursing staff, and lost bed-days due to prolonged hospital stay of identified carriers. The model was calibrated on actual datasets. Sensitivity analyses were performed.

Results

The baseline scenario resulted in 0.93 CPE acquisitions/1000 admissions and costs 32,050 €/1000 admissions. All control strategies increased costs and improved the outcome. The efficiency frontier was represented by: (1) TS with DNS at a 17,407 €/avoided CPE case, (2) TS + DNS + WSC at a 30,700 €/avoided CPE case and (3) US + DNS + WSC at 181,472 €/avoided CPE case. Other strategies were dominated. Sensitivity analyses showed that TS + CP might be cost-effective if CPE carriers are identified upon admission or if the cases have a short hospital stay. However, CP were effective only when high level of compliance with hand hygiene was obtained.

Conclusions

Targeted screening at admission combined with DNS for identified CPE carriers with or without weekly screening were the most cost-effective options to limit the spread of CPE. These results support current recommendations from several high-income countries.
Quantification of Campylobacter contamination on chicken carcasses sold in retail markets in the United Arab Emirates
Authors: Habib Ihab , Mohamed Mohamed-Yousif Ibrahim , Lakshmi Glindya Bhagya , Khan Mushtaq , Li Dan
Published: September 2022

Background

Campylobacter is among the leading causes of foodborne zoonotic disease worldwide, with chicken meat accounting for the majority of human illnesses. This baseline study generates the first quantitative data for Campylobacter contamination in the United Arab Emirates chicken meat. Such data will help inform risk analysis and develop evidence-based food safety management.

Methods

For a year, chilled whole chicken carcasses (n = 315) belonging to seven different companies were collected from retail supermarkets. According to standard methods, Campylobacter enumeration was achieved by a direct plating in all chicken samples, and isolates were confirmed using multiplex PCR.

Results

Campylobacter spp. were recovered from 28.6% (90/315) of the samples. Campylobacter enumeration results indicated that 71.4% of the tested samples were contaminated with < 1 log10 CFU (colony-forming units)/g, and 7% were contaminated with ≥3 log10 CFU/g. The mean Campylobacter concentration was 2.70 log10 CFU/g, with a standard deviation of 0.41 log10 CFU/g. Campylobacter counts varied significantly in relation to the sourcing chicken processing companies. Six out of the seven surveyed companies provided Campylobacter positive samples. Moreover, significantly higher (p-value< 0.0001) counts were found to be associated with smaller size chicken carcasses (weighted 600–700 g; compared to the other categories, 800 g and 900–1000 g). Interestingly, C. coli was present in 83% of the positive samples, while C. jejuni was only detected in 6.4% of the samples. Compared with studies from other countries utilizing the same enumeration method, the UAE chicken appears to have a lower prevalence but a higher Campylobacter count per gram of carcasses. Higher Campylobacter counts were significantly associated with smaller carcasses, and C. coli was the dominant species detected in this study’s samples.

Conclusion

These results add to our understanding of the local, regional and global epidemiology of Campylobacter in chicken meat. Outputs of the current study may aid in developing a risk assessment of Campylobacter in the UAE, a country among the biggest per capita consumption markets for chicken meat worldwide.
Ionospheric electron density modelling using B-splines and constraint optimization
Authors: Lalgudi Gopalakrishnan Ganesh , Schmidt Michael
Published: September 2022

Many modern applications, such as precise point positioning, autonomous driving or precision agriculture would benefit significantly if a high-precision and high-resolution model of electron density in the ionosphere and the plasmasphere would be globally available. Since the development of such a model still relies on data with insufficient and uneven global coverage, the consideration of background information and the introduction of equality and inequality constraints on Chapman key parameters are essential. In this work, we develop a multi-layer Chapman model based on B-spline expansions of selected key parameters of the electron density. The unknown series coefficients of the key parameters are subject to equality and inequality constraints. Finally, the developed model is applied to a combination of real and semi-simulated input data; the results are validated through ionosonde measurements.

Graphical Abstract
Multi-GNSS clock combination with consideration of inconsistent nonlinear variation and satellite-specific bias
Authors: Chen Guo , Guo Jing , Wei Na , Li Min , Zhao Qile , Tao Jun
Published: September 2022

As part of the International GNSS Service (IGS) multi-GNSS Pilot Project (MGEX), precise orbit and clock products for multi-GNSS constellations have been submitted by several analysis centers (ACs) since 2012. Based on the 30 s satellite clocks from 6 MGEX ACs, the multi-GNSS clocks are combined and the consistency of the AC clocks is assessed in this study. Usually, a linear transformation between the combined and AC solution is used for clock combination, and the clock residuals of the AC solution w.r.t the combined solution are used to determine the weights of the AC. However, any inconsistent satellite-specific bias or nonlinear variations in the clocks induced by the AC’s processing strategy can contaminate the linear transformation as well as the determination of the weight. In this study, the analysis center and satellite-specific bias (ASB) of the MGEX AC clock solutions is first identified and estimated by using observations from globally distributed stations. Moreover, the clock solutions with nonlinear variations induced by the reference clock or nonconstant intersystem bias (ISB) are corrected by aligning the clocks to the selected reference solution before clock combination. With the correction of the ASB, the root-mean-square of the clock residuals decreases significantly and reaches 14$$-$$
-
26, 37$$-$$
-
91, 33$$-$$
-
48 and 12$$-$$
-
44 ps for GPS, GLONASS, BDS-2 and Galileo, respectively. In general, the consistency of AC solutions w.r.t the combination reaches 8$$-$$
-
16, 27$$-$$
-
58, 13$$-$$
-
27 and 9$$-$$
-
36 ps for GPS, GLONASS, BDS-2 and Galileo in terms of the standard deviation. Finally, the individual AC and combined orbit as well as clock solutions of different constellations are assessed by precise point positioning, and the combined multi-GNSS solutions show competitive performance with the best AC solution in terms of both the positioning accuracy and stability of the reference frame parameters. However, inconsistent scale parameters of both the AC and combined solutions are identified and require more investigation.

Graphical Abstract
Association between adherence to the dietary approaches to stop hypertension (DASH) diet and maternal and infant sleep disorders
Authors: Karbasi Samira , Azaryan Ehsaneh , Zangooie Alireza , Zarban Asghar , Bahrami Afsane
Published: September 2022

Background

Maternal diet is known to be important to both mother and infant health. The purpose of this study was to evaluate the association between adherence to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern (DP) and sleep problems in mothers and their infants.

Methods

The study included 350 breastfeeding mothers with an average age of 29.5 ± 5.9 years. Psychological functions were performed using standard questionnaires, including a Quality-of-Life Questionnaire (QLQ), Edinburgh Postnatal Depression Scale (EPDS), Spielberger Anxiety Questionnaire (SAQ), Pittsburg Sleep Quality Index (PSQI), and Infant Sleep Questionnaire (ISQ). Also, a standardized food frequency questionnaire (FFQ) was used to identify adherence to the DASH DP.

Results

Subjects in the highest tertile of DASH DP had significantly lower scores of mother’s sleep latency (0.70 ± 1.18 vs. 1.24 ± 1.3; P value = 0.031), sleep disorders (4.3 ± 1.6 vs. 5.3 ± 2.4; P value= 0.032) and higher mother sleep efficiency compared to those in the lowest tertile (97.5 ± 89 vs. 54.8 ± 90; P value= 0.011). Also, infants of mothers with higher adherence to a DASH DP had lower sleep disorders compared with subjects with low adherence (4.9 ± 3.8 vs. 5.7 ± 3.2; P value= 0.017). After controlling for the mother’s education, economic status, age, body mass index (BMI), and energy intake, adherence to the DASH pattern was associated with shorter sleep latency (β = 0.60; 95%CI: 0.49–0.82), fewer sleep disorders score in mothers (β = 0.92; 95%CI: 0.85–0.99) and their infants (β = 0.90; 95%CI: 0.84–0.96) as well as high mother’s sleep efficiency (β = 1.2; 95%CI: 1.1–1.31).

Conclusions

According to our findings, adherence to DASH DP is associated with a lower score for sleep disorders in mothers and their infants.
Evaluation of the performance of GNSS-based velocity estimation algorithms
Authors: Ji Li , Sun Rui , Cheng Qi , Wang Junhui
Published: September 2022

Global Navigation Satellite System (GNSS) based velocity estimation is one of the most cost-effective and widely used methods in determining velocity in geodesy and transport applications. Highly accurate and reliable velocity measurements can be obtained by exploiting the raw Doppler, carrier phase, and pseudorange measurements with a GNSS receiver. There are several approaches to GNSS-based velocity determination. This paper investigates the characteristics of the approaches which are currently popular and applicable to the observations of Global Positioning System (GPS), BeiDou Navigation Satellite System (BDS), and their combination (GPS/BDS). Specifically, it evaluates the performance of the velocity estimated based on the Raw Doppler method, the Time-Differenced Pseudorange method, the Time-Differenced Carrier Phase method, and the Double-Differenced Carrier Phase method, in both static and dynamic modes and in open and urban scenarios. The experiments show that BDS has the advantages in delivering accurate velocity determinations over GPS in the Asia–Pacific region, and the effectiveness of the GPS/BDS in improving the overall accuracy of velocity determination in complex urban scenarios.
Selpercatinib in Patients With RET Fusion–Positive Non–Small-Cell Lung Cancer: Updated Safety and Efficacy From the Registrational LIBRETTO-001 Phase I/II Trial
Authors: Drilon Alexander , Subbiah Vivek , Gautschi Oliver , Tomasini Pascale , de Braud Filippo , Solomon Benjamin J. , Shao-Weng Tan Daniel , Alonso Guzmán , Wolf Jürgen , Park Keunchil , Goto Koichi , Soldatenkova Victoria , Szymczak Sylwia , Barker Scott S. , Puri Tarun , Bence Lin Aimee , Loong Herbert , Besse Benjamin
Published: September 2022

PURPOSE

Selpercatinib, a first-in-class, highly selective, and potent CNS-active RET kinase inhibitor, is currently approved for the treatment of patients with RET fusion–positive non–small-cell lung cancer (NSCLC). We provide a registrational data set update in more than double (n = 316) of the original reported population (n = 144) and better characterization of long-term efficacy and safety.

METHODS

Patients were enrolled to LIBRETTO-001, a phase I/II, single-arm, open-label study of selpercatinib in patients with RET-altered cancers. An analysis of patients with RET fusion–positive NSCLC, including 69 treatment-naive and 247 with prior platinum-based chemotherapy, was performed. The primary end point was objective response rate (ORR; RECIST v1.1, independent review committee). Secondary end points included duration of response (DoR), progression-free survival (PFS), overall survival, and safety.

RESULTS

In treatment-naive patients, the ORR was 84% (95% CI, 73 to 92); 6% achieved complete responses (CRs). The median DoR was 20.2 months (95% CI, 13.0 to could not be evaluated); 40% of responses were ongoing at the data cutoff (median follow-up of 20.3 months). The median PFS was 22.0 months; 35% of patients were alive and progression-free at the data cutoff (median follow-up of 21.9 months). In platinum-based chemotherapy pretreated patients, the ORR was 61% (95% CI, 55 to 67); 7% achieved CRs. The median DoR was 28.6 months (95% CI, 20.4 to could not be evaluated); 49% of responses were ongoing (median follow-up of 21.2 months). The median PFS was 24.9 months; 38% of patients were alive and progression-free (median follow-up of 24.7 months). Of 26 patients with measurable baseline CNS metastasis by the independent review committee, the intracranial ORR was 85% (95% CI, 65 to 96); 27% were CRs. In the full safety population (n = 796), the median treatment duration was 36.1 months. The safety profile of selpercatinib was consistent with previous reports.

CONCLUSION

In a large cohort with extended follow-up, selpercatinib continued to demonstrate durable and robust responses, including intracranial activity, in previously treated and treatment-naive patients with RET fusion–positive NSCLC.
Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline
Authors: Mao Jun J. , Ismaila Nofisat , Bao Ting , Barton Debra , Ben-Arye Eran , Garland Eric L. , Greenlee Heather , Leblanc Thomas , Lee Richard T. , Lopez Ana Maria , Loprinzi Charles , Lyman Gary H. , MacLeod Jodi , Master Viraj A. , Ramchandran Kavitha , Wagner Lynne I. , Walker Eleanor M. , Bruner Deborah Watkins , Witt Claudia M. , Bruera Eduardo
Published: September 2022

PURPOSE

The aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other health care providers on integrative approaches to managing pain in patients with cancer.

METHODS

The Society for Integrative Oncology and ASCO convened an expert panel of integrative oncology, medical oncology, radiation oncology, surgical oncology, palliative oncology, social sciences, mind-body medicine, nursing, and patient advocacy representatives. The literature search included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2021. Outcomes of interest included pain intensity, symptom relief, and adverse events. Expert panel members used this evidence and informal consensus to develop evidence-based guideline recommendations.

RESULTS

The literature search identified 227 relevant studies to inform the evidence base for this guideline.

RECOMMENDATIONS

Among adult patients, acupuncture should be recommended for aromatase inhibitor–related joint pain. Acupuncture or reflexology or acupressure may be recommended for general cancer pain or musculoskeletal pain. Hypnosis may be recommended to patients who experience procedural pain. Massage may be recommended to patients experiencing pain during palliative or hospice care. These recommendations are based on an intermediate level of evidence, benefit outweighing risk, and with moderate strength of recommendation. The quality of evidence for other mind-body interventions or natural products for pain is either low or inconclusive. There is insufficient or inconclusive evidence to make recommendations for pediatric patients. More research is needed to better characterize the role of integrative medicine interventions in the care of patients with cancer. Additional information is available at https://integrativeonc.org/practice-guidelines/guidelines and www.asco.org/survivorship-guidelines .
Trial Registry Use in Neurosurgery Systematic Reviews With Meta-Analyses: A Cross-Sectional Analysis
Authors: Bertolino Blake , Rivera Steven , Perez Brenda , Reddy Arjun K. , Vassar Matt
Published: September 2022

BACKGROUND:

Quality systematic reviews with meta-analyses (SRMA's) are the standard for recommendations in clinical practice. One problem with the current literature is susceptibility to publication bias, which has been shown to inflate effect estimates of SRMA's.

OBJECTIVE:

To combat publication bias, Cochrane Collaboration requires searching at least 1 clinical trial registry (CTR) for unpublished data. Therefore, we investigated SRMA's published in the top 5 neurosurgery journals and whether they incorporated CTR searches.

METHODS:

All meta-analyses published the top 5 journals in Neurosurgery over the past 5 years were queried using the h-5 index of Google Scholar: Journal of Neurosurgery, Neurosurgery, World Neurosurgery, Journal of Neurosurgery: Spine, and Neurosurgical Focus. Search strings were generated to incorporate SRMA's over the past 5 years in these journals. We selected a random sample of 100 studies from the list of SRMA's that did not incorporate CTR searches and searched ClinicalTrials.gov for unpublished, completed CTR's with relevant outcomes.

RESULTS:

Of 761 papers, 22/761 searched CTR's, meaning only 2.8% of SRMA's in these journals included CTR data. Among 100 randomized papers in secondary analysis, 39% had relevant CTR data, and 16 of those 39 papers had multiple sets of data relevant to the study (41%). Meanwhile, papers published by Cochrane had 69 of 72 reviews (95.8%) that included CTR searches.

CONCLUSION:

This shows that the top neurosurgery journals seldom published SRMA's containing searches for unpublished CTR's while Cochrane almost always had searches. In addition, 41% of the randomized sample in our secondary analysis could have included CTR studies.
Ο ρόλος της υπερηχογραφικής μελέτης της νεφρικής λειτουργίας στην πρόγνωση της νεφρικής βλάβης στους βαρέως πάσχοντες ασθενείς
Authors: Φωτοπούλου Γεωργία
Published: September 2022

Σκοπός: Nα διερευνήσουμε την αποτελεσματικότητα του δείκτη renal resistive index (RRI)στην πρόβλεψη της οξείας νεφρικής βλάβης (ΟΝΒ) και της σχέσης που θα μπορούσε να έχειμε παραμέτρους ιστικής υποάρδευσης στους βαρέως πάσχοντες ασθενείς της μονάδαςεντατικής θεραπείας (ΜΕΘ). Η σχέση των παραπάνω δεικτών με την κλινική έκβαση τωνασθενών ήταν δευτερεύον καταληκτικό σημείο.Μέθοδος: Σε όλους τους ασθενείς που εισήχθησαν διαδοχικά στη ΜΕΘ και είχαν ανάγκημηχανικού αερισμού, μετρήθηκε ο δείκτης RRI εντός 24 ωρών από την εισαγωγή. Ο λόγοςP(cv-a)CO2 / C(a-cv)O2 και το γαλακτικό οξύ του αρτηριακού αίματος χρησιμοποιήθηκαν ωςδείκτες γενικευμένης ιστικής υποξίας.Αποτελέσματα: Συνολικά μελετήθηκαν 126 ασθενείς υπό μηχανική υποστήριξη της αναπνοής[διάμεσος ηλικία 61 (IQR 28) έτη, 74% άρρεν φύλο]. Σαράντα τέσσερις (42.9%) ασθενείςανέπτυξαν ΟΝΒ. Η θνητότητα εντός ΜΕΘ ήταν 27%. Η διάμεσος τιμή RRI ήταν 0.68 (0.1) στουςασθενείς χωρίς ΟΝΒ και 0.82 (0.07) στους ασθενείς με ΟΝΒ , p<0.001. Στην πολυπαραγοντικήλογιστική παλινδρόμηση ο δείκτης RRI αναδείχθηκε ως ανεξάρτητος παράγοντας πρόβλεψηςΟΝΒ ( για RRI>0.7, OR 17.7; 95%CI: 2.8-111.1, p=0.002). Η καμπύλη AUC ROC για τηνπρόβλεψη ΟΝΒ με τον δείκτη RRI ήταν 0.936. Ο δείκτης RRI συσχετίζεται σημαντικά τόσο μετο λόγο P(cv-a)CO2/C(a-cv)O2 όσο και με το γαλακτικό, r=0.64, p<0.0001 και στις δύο περιπτώσεις.Ο συνδυασμός RRI και P(cv-a)CO2)/(C(a-cv)O2 σχετίζεται καλύτερα με την κλινική έκβαση σε σχέσημε τον RRI μόνο (AUC ROC 0.83 έναντι 0.749, αντίστοιχα).Συμπέρασμα: Στους βαρέως πάσχοντες ασθενείς η τιμή του δείκτη RRI κατά την εισαγωγή στηΜΕΘ αποτελεσματικά μπορεί να εντοπίσει τους ασθενείς με υψηλή πιθανότητα εμφάνισης ΟΝΒκαι συσχετίζεται ικανοποιητικά με παραμέτρους γενικευμένης ιστικής υποάρδευσης.Επιπροσθέτως, ο συνδυασμός των παραπάνω δεικτών είναι πιο αξιόπιστος στην πρόβλεψητης κλινικής έκβασης των ασθενών στη ΜΕΘ.
Η συμβολή της θεατροπαιδαγωγικής στη διαπραγμάτευση της κοινωνικής ταυτότητας από μεικτές ομάδες αναπήρων και μη αναπήρων
Authors: Κολτσίδα Μαρία
Published: September 2022

Στο σύγχρονο ελληνικό εκπαιδευτικό και καλλιτεχνικό τοπίο όπου οι θεατροπαιδαγωγικές πρακτικές στον χώρο της αναπηρίας εντός τυπικών και μη τυπικών εκπαιδευτικών πλαισίων προκαλούν σταδιακά το ενδιαφέρον εκπαιδευτικών, θεατροπαιδαγωγών και καλλιτεχνών, μια ερευνητική και συστηματική μελέτη των πεδίων αυτών κρίνεται απαραίτητη. Σκοπός της παρούσας διδακτορικής διατριβής είναι η διερεύνηση της σύμπραξης ανάπηρων και μη ανάπηρων συμμετεχόντων σε μη τυπικά εκπαιδευτικά πλαίσια σε σχέση με τη διαπραγμάτευση της κοινωνικής τους ταυτότητας στη θεατροπαιδαγωγική συνθήκη. Ο ερευνητικός σχεδιασμός, ο οποίος λαμβάνει τη μορφή της χειραφετικής έρευνας-δράσης σε συνδυασμό με τη μέθοδο της κριτικής εθνογραφίας, στηρίζεται στο ποιοτικό παράδειγμα και αποβλέπει στην ανάδυση του τρόπου με τον οποίο οι συμμετέχοντες διαπραγματεύονται τις κοινωνικές τους ταυτότητες μέσα σε ένα θεατροπαιδαγωγικό εργαστήρι. Για τη μελέτη των παραπάνω, ως εργαλεία παραγωγής δεδομένων χρησιμοποιούνται η συνέντευξη, οι ομάδες εστίασης, η συμμετοχική παρατήρηση, τα αναστοχαστικά ημερολόγια της ερευνήτριας, η καταγραφή οπτικοακουστικού υλικού και οι γραπτές ή προφορικές καταγραφές των συμμετεχόντων κατά τη διαδικασία και η έρευνα μέσω της τέχνης. Η εν λόγω έρευνα φιλοδοξεί να ακροαστεί και να ενδυναμώσει τη φωνή των ανάπηρων και μη ανάπηρων συμμετεχόντων και, μέσω της μεθόδου ανάλυσης των ερευνητικών δεδομένων, να αναδείξει τις ιστορίες τους, αναδεικνύοντας διαφορετικούς τρόπους κατανόησης των μορφών με τις οποίες τα άτομα εκφράζονται για τον εαυτό τους, τους Άλλους και το κοινωνικό περιβάλλον.
STRESS MANAGEMENT IN THE ORGANIZATION OF THE SERVICE SECTOR
Authors: Solovova N. , Kalmykova O.
Published: September 2022

The article substantiates the importance of methods for preventing stress factors in the organizational environment and increasing the level of stress competence of managers and employees of a service sector organization. The results of sociological research conducted among the personnel of the organization of the service sector are presented. The subject of the study is the methods and personnel activities of stress management at the organizational and personal levels in organizations in the service sector.

The study used diagnostic tools: stress monitoring, which allows assessing the stress factors of the organizational environment; to assess the satisfaction of employees with working conditions and the emotional state of the staff (K.E. Oksinoid); a methodology for assessing the personnel risks of an organization, which makes it possible to build a profile of the organization's personnel risks (Mitrofanova A.E.); peer review method; a method for diagnosing the comfort of the organization's behavioral space (K.E. Oksinoid). In the course of the study, practical recommendations were formed in the field of stress management of the organization of the service sector.
The Changing Role of Human Resources in Organizations and Trends in HRM in the Age of Digitalization
Authors: Babayan Karine
Published: September 2022

The era of digitalization has brought a new philosophy to the field of human resource management, predetermining a further change in attitudes towards work and the role of a person in an organization.

In this regard, it seems relevant to identify trends in the HRM of organizations in the short term, taking into account the challenges of the digital ecosystem. The article defines the conceptual essence of modern HRM; the positive and negative factors of digitalization of many processes related to HRM, both at the level of each organization and in general for the labor market, were studied; analyzed possible changes in relation to the role of a person and assessed the prospect of employment through the formation of new professions; the main HRM trends of organizations are outlined in the visible future in connection with the introduction of digital technologies.
INFLUENCE OF MASS UNBALANCE ON A SMALL-CALIBER PROJECTILE TRAJECTORY
Authors: BRIEY V. , MARINUS B. G.
Published: September 2022

The purpose of this article is to use an uncoupled method based on Rigid Body Dynamics (RBD) and Computational Fluid Dynamics (CFD), to determine the aerodynamic coefficients of geometrically symmetric small-caliber projectiles but with a fixed mass asymmetry to complement previous findings in large caliber. In addition to having to take into account the evolution as a function of the yaw angle and the Mach number for the calculation of the coefficients, a common 6-DoF model is adapted to also take into account the unbalance position in flight without any modification of the twelve differential equations of motion. It appears very clearly that the effects related to the presence of the unbalance are much more important at the exit of the tube, than in air, since the orientation problems are quickly compensated by the gyroscopic effect whereas the direction of the trajectory is definitely deviated.
ESTIMATION OF THE VELOCITY OF A PROJECTILE USING RADIAL ACCELEROMETERS—VALIDATION ON 155 MM FREE FLIGHT TEST
Authors: FIOT AURÉLIEN , CHANGEY SÉBASTIEN , ADAM RONAN , PETIT NICOLAS
Published: September 2022

This paper addresses the problem of velocity estimation for a 155 mm projectile. Indeed, to correctly feed the guidance and control algorithms of such a guided munition, it is essential to estimate its speed autonomously (without any external system) onboard and in real-time. Knowledge of the velocity (and thus the Mach number) is required to infer the aerodynamic coefficients governing its dynamics. From the analysis of the frequencies present on one of the radial accelerometers, and from a reduced 6DOF model describing the epicyclic rotation of the shell, we are able to estimate the velocity of the ammunition. The roll speed can be determined from magnetometers. For frequency estimation, we employ a subspace method of the Pisarenko type, relying on the auto-correlation matrix of the accerelometer signal. This matrix is estimated from samples and its dominant eigenvalues are related to the precession and nutation frequencies. In turn, the velocity can be estimated from the analytical values of the epicyclic motion. In this paper, we offer an efficient method to estimate the velocity of an artillery shell in free-flight, using only embedded sensors. The next step will be to use these results to improve the estimation of the projectile’s attitude and position.
INCREASING THE ACCURACY OF THE RANGE CORRECTIONS FOR THE AIR VIRTUAL TEMPERATURE
Authors: CECH VLADIMIR , ROZEHNAL ONDREJ
Published: September 2022

If for any reason it is not possible to use an automated fire control system, then especially in combat conditions it is necessary to use an alternative method of calculating the mean point of impact position. To do this, tabular firing tables (TFT) are used together with the corresponding type of artillery meteorological message. If TFTs created according to STANAG 4119 are used, only the met message METB3Q must be used for surface-tosurface fire. The calculation of corrections for deviations in virtual temperature is very problematic. We have been dealing with the problem since 2013. In this article, we propose a solution that increases the accuracy of calculations and is applicable in combat conditions. However, the main advantage of the proposed method is the fact that met data can be obtained from any available met message (METB3Q, Meteo - 11 (meteo - average), METCMQ, METGM and GRIB).
MAGNUS EFFECT OF YAWING-SPINNING TARGET PRACTICE PROJECTILES: GYROSCOPIC AND DYNAMIC INSTABILITIES IN SUPERSONIC FLIGHT
Authors: CAYZAC ROXAN C , CARETTE ERIC C , ZEIDLER MICKAEL
Published: September 2022

Despite extensive studies, mechanisms governing the aeroballistics of yawing and spinning projectiles are still difficult to understand. This is especially true for target practice projectiles settled with additional roll damping devices. The first part of the paper is devoted to the aerodynamic comparison of classical and target practice projectiles. For classical projectiles it is known that, at small angles of attack, the spin induces a weak asymmetry of the boundary layer profiles. For target practice projectiles, the roll damping devices, settled as longitudinal grooves, could generate important modifications of the flow. Grooves act on the boundary layer asymmetry, strongly increasing the Magnus moment. The second part of the paper, based on 6 degrees of freedom computations, is devoted to the prediction of flight dynamic behavior. According to the grooves design, dynamic and gyroscopic instabilities could appear. The influence of grooves depth on the inflight behavior is highlighted.
UNCERTAINTY: WHAT DOES IT MEAN FOR BALLISTIC CHRONOGRAPHS?
Authors: MAGNAN STÉPHANE , SHEWCHENKO NICHOLAS
Published: September 2022

Two of the most cited performance properties of ballistic armour systems that characterize resistance to penetration are the ballistic limit (V50) and the proof velocity (Vproof). It is therefore critical that the test velocities are measured with a high degree of certainty for gaining confidence in the ballistic performance assessment for research and development, demonstration of compliance, and quality control purposes (i.e., ISO 17025). Unfortunately, common ballistic testing standards (NIJ 0101.06, ASTM E3062, etc.) do not provide sufficient clarity regarding contributors to consider, coverage factors, or interpretation of stated accuracy limits, leaving significant room for interpretation. This work applies principles of the Guide to the expression of uncertainty in measurement (GUM) to a COTS ballistic chronograph (SpeedTube™) to form a basis for discussions regarding interpretation of standards and the need for standards to use language consistent with the International Vocabulary of Metrology (VIM) for the benefit of researchers, manufacturers, and test facilities.
EXPERIMENTAL STUDY ON THE SHOCK-INDUCED REACTION CHARACTERISTICS OF PTFE/AL/BI2O3 REACTIVE MATERIALS
Authors: HU RONG , JIANG CHUNLAN , MAO LIANG , QI YUXUAN , WANG ZAICHENG
Published: September 2022

Four PTFE/Al/Bi2O3 ternary reactive materials with different Al contents were prepared by molded sintering method to obtain the influence of Al content on the mechanical properties and impact reaction characteristics of PTFE/Al/Bi2O3 ternary reactive materials, and their mechanical and reaction properties were tested by drop-weight test and the shock induced reaction phenomena were observed by high-speed camera. The results show that the characteristic drop height first decreases and then increases as the Al content increases from 24% to 48%, and the reaction delay time remains unchanged, and the reaction duration first increases and then decreases. When the Al excess is doubled, its reaction is the most intense, the duration is the longest, and the reactivity reaches the strongest. The results of the study can provide some reference for the engineering application of PTFE/Al/Bi2O3
Case Article—GAP: A Humanitarian Initiative of Ramakrishna Mission for Underprivileged Children
Authors: Ramani Vinay , Dalal Jyotirmoy , Dayakarananda Swami
Published: September 2022

Conventional textbook models of profit-maximizing firms are generally unsuitable for understanding and modeling the objectives of a nonprofit organization. Closing this gap is especially important as nonprofits, regarded as the third pillar of the society, are increasingly prevalent along with the government and the for-profit businesses. GAP, a humanitarian project undertaken by Ramakrishna Mission (RKM), a large nonprofit organization in India, has been highlighted in our case. Our case serves three pedagogical objectives: (i) understanding the cost structure that is specific to the GAP project, (ii) applying break-even analysis, and (iii) quantitative modeling of the nonprofit’s decision-making problem using a simple spreadsheet modeling approach. The case has been tested across a diverse set of courses across different MBA programs at two public business schools in India. In all those courses, students found the case challenging but were appreciative of the hands-on experience gained by working on a real-life decision-making problem.
Prinsip-Prinsip Bahan Tambahan Pangan Yang Memenuhi Syarat Halal: Alternatif Penyedap Rasa Untuk Industri Makanan Halal
Authors: Perdani Claudia , Mawarni Ruli Retno , Mahmudah Liayati , Gunawan Setiyo
Published: September 2022

Indonesia merupakan negara dengan mayoritas penduduk beragama Islam sekitar 87%, sehingga permintaan produk halal di Indonesia juga cukup besar. Makanan halal merupakan    makanan    bergizi    yang    tidak mengandung   bahan   maupun   unsur   yang dilarang atau haram untuk dikonsumsi baik bahan   baku, bahan   tambahan dan   bahan penolong, termasuk didalamnya adalah penyedap rasa. Perkembangan industri penyedap rasa makanan di Indonesia terlihat semakin banyak diminati oleh masyarakat. Tujuan dari review ini adalah untuk meringkas prinsip-prinsip dasar memproduksi penyedap rasa serta memahami titik kendali dalam produksi penyedap rasa agar dapat meningkatkan jangkauan produk makanan halal. Dengan adanya informasi ini diharapkan dapat menjadi panduan dalam menentukan penyedap rasa yang sesuai dengan kebutuhan produk dan dapat memenuhi persyaratan kehalalan yang berlaku di Indonesia. Penyedap rasa dapat dibuat melalui berbagai proses baik enzimatis, kimiawi maupun sintesis mikroorganisme, dimana dalam review ini disajikan daftar titik kritis halal penyedap rasa dari setiap proses. Konsumen muslim sebaiknya memperhatikan apakah penyedap rasa tersebut berbasis hewani atau nabati, jika berbasis hewani maka harus memperhatikan sumber hewannya apakah berasal dari hewan yang halal dan proses penyembelihannya sesuai kaidah islam. Sedangkan untuk bahan nabati relatif lebih minim untuk titik kritisnya. Untuk penyedap rasa berbasis proses enzimatis dan hasil sintesis mikroorganisme sebaiknya dipilih yang telah memiliki sertifikat halal, komponen tersebut harus berasal dari sumber yang halal.
Quality Comparison of Low- and High-Moisture Meat Analog Used in Plant-Based Burger Patty
Authors: Cho Sun Young , Ryu Gi-Hyung
Published: September 2022

This study aims to investigate the physicochemical properties of meat analogs by using high and low moisture extrusion processes to create a plant-based analog burger patty material. The isolated soy protein blends of low- and high-meat analogs (LMMA and HMMA) were texturized using the twin-screw extruder equipped with a cooling die. The highest hardness, cohesiveness, chewiness, and cutting strength were observed in beef, but the highest stringiness was indicated in HMMA. The highest integrity index was seen in beef, while LMMA had the highest nitrogen solubility index (NSI). LMMA also had the highest water holding capacity (WHC) and water absorption capacity (WAC), whereas beef had the highest oil absorption capacity (OAC). LMMA had the highest emulsifying activity (EA) and emulsion stability (ES) in emulsifying properties. Further, the highest protein digestibility was revealed in LMMA. This study suggested that extrusion process types influence the quality of meat analog, which could be the elementary source for manufacturing the analog burger patty.
A Study on the Isolation and Characterization of Aerobic Halophilic Microorganisms Isolated from the Soil Around the Port on Jeju Island
Authors: Lee Yong-Jik , Ganbat Dariimaa , Jeong Ga Eul , Shin Kee-Sun , Lee Sang-Jae
Published: September 2022

To isolate aerobically and identify the diversity of halophilic bacteria in the soil around two ports, Daepopogu and Hwasun Port, on Jeju island, a total 46 halophilic bacteria strains were isolated and phylogenetically analysed. The isolated strains were divided into 3 phyla, 8 families, 16 genera and 23 species. The main taxa was the Bacilli class, which included 50.0% of the strains with 3 families, 10 genera and 15 species of Bacillaceae, Exiguobacterium_f and Planococcaceae. The second taxa was the Gammaproteobacteria class, which included 45.7% of the strains with 4 families, 5 genera and 7 species of Aeromonadaceae, Halomonadaceae, Marinobacteraceae and Vibrionaceae. The isolated strains were tested for hydrolytic enzymes, amylase, lipase and protease activity, and 31 strains showed activity of at least one enzyme. Furthermore, auxin activity was determined in 7 strains. This study showed that the isolated strains have possible applications in the food and agricultural industries and have importance as a genetic resource in Korea.
Quality Properties of Sponge Cake According to Replacement Ratio of Allulose
Authors: Lee Hye-Won , Shin Jung-Kue
Published: September 2022

In this study, the quality properties were compared by replacing allulose with a ratio of 0%-100% instead of sugar used in sponge cake. There was no significant difference in specific gravity, pH, and degree Brix of the dough according to the allulose content, but the brightness decreased and the redness, and yellowness increased as the allulose content increased. The volume of the sponge cake decreased as the content of allulose increased. Symmetry was uniform in the cakes replaced with allulose compared to 100% sugar. There was no significant difference in baking loss and moisture content. Hardness, gumminess and chewiness increased as the replacement rate of allulose increased, and adhesiveness was highest in 100% allulose. In the hedonic evaluation, 100% sugar and allulose 25% samples showed no difference, and the other samples were evaluated lower than the control. The maximum replacement ratio of allulose for sponge cake is considered to be 50%.
Quality Characteristics of Emulsion-Type Chicken Breast Sausages with Black Soldier Fly Larvae (Hermetia illucens L.) Powder
Authors: Kang Hun-Seok , Boo Jun-Hyuk , Nam Jung-Hyun , Hyun Ji-Yong , Chun Ji-Yeon
Published: September 2022

This study investigated the quality characteristics of emulsion-type chicken breast sausages containing black soldier fly larvae (BSFL) powder. The chicken breast and BSFL powder were added at various mixing ratios (C:chicken breast 56% and BSFL powder 0%, 1%:chicken breast 55% and BSFL powder 1%, 2%:chicken breast 54% and BSFL powder 2%, 3%:chicken breast 53% and BSFL powder 3%). The pH, moisture content, and water holding capacity of the sausages increased with the powder amount. In the instrumental color evaluation, the L* and b* values were significantly different among the samples (p<0.05). However, there was no significant difference in a* value (P>0.05) with the amount of powder added. Volatile basic nitrogen and acid value tended to increase with the amount of BSFL powder. The total phenolic content tended to increase, but the value of IC50 according to DPPH radical scavenging decreased as the amount of powder increased. This study concluded that BSFL powder can be used in meat products processing as a substitute for meat protein and may also improve antioxidant activity.
A Study on the Production and Quality Characteristics of Bacterial Cellulose Film Using Coffee By-Products
Authors: Oh Hae Won , Lee Seung Hwan
Published: September 2022

This study was carried out to examine the physical characteristics of bacterial cellulose (BC) and its optimal culture condition using coffee by-products. Recently, recycling resources and employing eco-friendly materials have been raised as significant issues in the food industry. As the coffee industry develops, interests and efforts for recycling coffee wastes are also growing. This study attempted to confirm the production of BC by utilizing spent coffee grounds filtrate as a medium. In order to confirm the optimal culture conditions for BC production, different culture methods, initial pH, culture temperature, and culture period were examined. The optimal pH and temperature were 6.0 and 30°C, and the optimal culture period was 14 days. The cultivated BC was dried by hot air drying, freezedrying, and mold drying, respectively. Then, the properties of the BC films, such as tensile strength, elongation, water-solubility, thickness, and chromaticity were compared. The drying method affected the shape and structure of the final BC films. The production of BC film is expected to expand opportunities for recycling coffee by-products and contribute to solving environmental problems caused by food waste.
Validation of photoacoustic/ultrasound dual imaging in evaluating blood oxygen saturation
Authors: Liu Sirui , Zhang Rui , Han Tao , Pan Yinhao , Zhang Guangjie , Long Xing , Zhao Chenyang , Wang Ming , Li Xuelan , Yang Fang , Sang Yuchao , Zhu Lei , He Xujin , Li Jianchu , Zhang Yewei , Li Changhui , Jiang Yuxin , Yang Meng
Published: September 2022

Photoacoustic imaging (PAI) was performed to evaluate oxygen saturation (sO2) of blood-mimicking phantoms, femoral arteries in beagles, and radial arteries in humans at various sO2 plateaus. The accuracy (root mean square error, RMSE) of PAI sO2 compared with reference sO2 was calculated. In blood-mimicking phantoms, PAI achieved an accuracy of 1.49% and a mean absolute error (MAE) of 1.09% within 25 mm depth, and good linearity (R = 0.968; p < 0.001) was obtained between PAI sO2 and reference sO2. In canine femoral arteries, PAI achieved an accuracy of 2.16% and an MAE of 1.58% within 8 mm depth (R = 0.965; p < 0.001). In human radial arteries, PAI achieved an accuracy of 3.97% and an MAE of 3.28% in depth from 4 to 14 mm (R = 0.892; p < 0.001). For PAI sO2 evaluation at different depths in healthy volunteers, the RMSE accuracy of PAI sO2 increased from 2.66% to 24.96% with depth increasing from 4 to 14 mm. Through the multiscale method, we confirmed the feasibility of the hand-held photoacoustic/ultrasound (PA/US) in evaluating sO2. These results demonstrate the potential clinical value of PAI in evaluating blood sO2. Consequently, protocols for verifying the feasibility of medical devices based on PAI may be established.
Multidimensional quantitative characterization of the tumor microenvironment by multicontrast nonlinear microscopy
Authors: Li Yanping , Shen Binglin , Lu Yuan , Shi Jinhui , Zhao Zewei , Li Huixian , Hu Rui , Qu Junle , Liu Liwei
Published: September 2022

Characterization of the microenvironment features of tumors, such as its microstructures, biomolecular metabolism, and functional dynamics, may provide essential pathologic information about the tumor, tumor margin, and adjacent normal tissue for early and intraoperative diagnosis. However, it can be particularly challenging to obtain faithful and comprehensive pathological information simultaneously from unperturbed tissues due to the complexity of the microenvironment in organisms. Super-multiplex nonlinear optical imaging system emerged and matured as an attractive tool for acquisition and elucidation of the nonlinear properties correlated with tumor microenvironment. Here, we introduced a nonlinear effects-based multidimensional optical imaging platform and methodology to simultaneously and efficiently capture contrasting and complementary nonlinear optical signatures of freshly excised human skin tissues. The qualitative and quantitative analysis of autofluorescence (FAD), collagen fiber, and intracellular components (lipids and proteins) illustrated the differences about morphological changes and biomolecular metabolic processes of the epidermis and dermis in different skin carcinogenic types. Interpretation of multi-parameter stain-free histological findings complements conventional H&E-stained slides for investigating basal cell carcinoma and pigmented nevus, validates the platform’s versatility and efficiency for classifying subtypes of skin carcinoma, and provides the potential to translate endogenous molecule into biomarker for assisting in rapid cancer screening and diagnosis.