bluuebunny/crossref_metadata_2025 huggingface dataset:
A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma
Authors: Radhakrishnan Aneesha , Nanjappa Vishalakshi , Raja Remya , Sathe Gajanan , Puttamallesh Vinuth N. , Jain Ankit P. , Pinto Sneha M. , Balaji Sai A. , Chavan Sandip , Sahasrabuddhe Nandini A. , Mathur Premendu P. , Kumar Mahesh M. , Prasad T. S. Keshava , Santosh Vani , Sukumar Geethanjali , Califano Joseph A. , Rangarajan Annapoorni , Sidransky David , Pandey Akhilesh , Gowda Harsha , Chatterjee Aditi
Published: October 2016

Despite advances in clinical management, 5-year survival rate in patients with late-stage head and neck squamous cell carcinoma (HNSCC) has not improved significantly over the past decade. Targeted therapies have emerged as one of the most promising approaches to treat several malignancies. Though tyrosine phosphorylation accounts for a minority of total phosphorylation, it is critical for activation of signaling pathways and plays a significant role in driving cancers. To identify activated tyrosine kinase signaling pathways in HNSCC, we compared the phosphotyrosine profiles of a panel of HNSCC cell lines to a normal oral keratinocyte cell line. Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) was one of the kinases hyperphosphorylated at Tyr-321 in all HNSCC cell lines. Inhibition of DYRK1A resulted in an increased apoptosis and decrease in invasion and colony formation ability of HNSCC cell lines. Further, administration of the small molecular inhibitor against DYRK1A in mice bearing HNSCC xenograft tumors induced regression of tumor growth. Immunohistochemical labeling of DYRK1A in primary tumor tissues using tissue microarrays revealed strong to moderate staining of DYRK1A in 97.5% (39/40) of HNSCC tissues analyzed. Taken together our results suggest that DYRK1A could be a novel therapeutic target in HNSCC.
Myocyte-specific enhancer factor 2C: a novel target gene of miR-214-3p in suppressing angiotensin II-induced cardiomyocyte hypertrophy
Authors: Tang Chun-Mei , Liu Fang-zhou , Zhu Jie-Ning , Fu Yong-Heng , Lin Qiu-Xiong , Deng Chun-Yu , Hu Zhi-Qin , Yang Hui , Zheng Xi-Long , Cheng Jian-Ding , Wu Shu-Lin , Shan Zhi-Xin
Published: October 2016

The role of microRNA-214-3p (miR-214-3p) in cardiac hypertrophy was not well illustrated. The present study aimed to investigate the expression and potential target of miR-214-3p in angiotensin II (Ang-II)-induced mouse cardiac hypertrophy. In mice with either Ang-II infusion or transverse aortic constriction (TAC) model, miR-214-3p expression was markedly decreased in the hypertrophic myocardium. Down-regulation of miR-214-3p was observed in the myocardium of patients with cardiac hypertrophy. Expression of miR-214-3p was upregulated in Ang-II-induced hypertrophic neonatal mouse ventricular cardiomyocytes. Cardiac hypertrophy was attenuated in Ang-II-infused mice by tail vein injection of miR-214-3p. Moreover, miR-214-3p inhibited the expression of atrial natriuretic peptide (ANP) and β-myosin heavy chain (MHC) in Ang-II-treated mouse cardiomyocytesin vitro. Myocyte-specific enhancer factor 2C (MEF2C), which was increased in Ang-II-induced hypertrophic mouse myocardium and cardiomyocytes, was identified as a target gene of miR-214-3p. Functionally, miR-214-3p mimic, consistent with MEF2C siRNA, inhibited cell size increase and protein expression of ANP and β-MHC in Ang-II-treated mouse cardiomyocytes. The NF-κB signal pathway was verified to mediate Ang-II-induced miR-214-3p expression in cardiomyocytes. Taken together, our results revealed that MEF2C is a novel target of miR-214-3p, and attenuation of miR-214-3p expression may contribute to MEF2Cexpressionin cardiac hypertrophy.
Cerebellar theta burst stimulation modulates the neural activity of interconnected parietal and motor areas
Authors: Casula Elias Paolo , Pellicciari Maria Concetta , Ponzo Viviana , Stampanoni Bassi Mario , Veniero Domenica , Caltagirone Carlo , Koch Giacomo
Published: October 2016

Voluntary movement control and execution are regulated by the influence of the cerebellar output over different interconnected cortical areas, through dentato-thalamo connections. In the present study we applied transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to directly assess the effects of cerebellar theta-burst stimulation (TBS) over the controlateral primary motor cortex (M1) and posterior parietal cortex (PPC) in a group of healthy volunteers. We found a TBS-dependent bidirectional modulation over TMS-evoked activity; specifically, cTBS increased whereas iTBS decreased activity between 100 and 200 ms after TMS, in a similar manner over both M1 and PPC areas. On the oscillatory domain, TBS induced specific changes over M1 natural frequencies of oscillation: TMS-evoked alpha activity was decreased by cTBS whereas beta activity was enhanced by iTBS. No effects were observed after sham stimulation. Our data provide novel evidence showing that the cerebellum exerts its control on the cortex likely by impinging on specific set of interneurons dependent on GABA-ergic activity. We show that cerebellar TBS modulates cortical excitability of distant interconnected cortical areas by acting through common temporal, spatial and frequency domains.
Glycosylation changes in the globular head of H3N2 influenza hemagglutinin modulate
receptor binding without affecting virus virulence
Authors: Alymova Irina V. , York Ian A. , Air Gillian M. , Cipollo John F. , Gulati Shelly , Baranovich Tatiana , Kumar Amrita , Zeng Hui , Gansebom Shane , McCullers Jonathan A.
Published: October 2016

Since the emergence of human H3N2 influenza A viruses in the pandemic of 1968, these
viruses have become established as strains of moderate severity. A decline in
virulence has been accompanied by glycan accumulation on the hemagglutinin globular
head, and hemagglutinin receptor binding has changed from recognition of a broad
spectrum of glycan receptors to a narrower spectrum. The relationship between
increased glycosylation, binding changes, and reduction in H3N2 virulence is not
clear. We evaluated the effect of hemagglutinin glycosylation on receptor binding
and virulence of engineered H3N2 viruses. We demonstrate that low-binding virus is
as virulent as higher binding counterparts, suggesting that H3N2 infection does not
require either recognition of a wide variety of, or high avidity binding to,
receptors. Among the few glycans recognized with low-binding virus, there were two
structures that were bound by the vast majority of H3N2 viruses isolated between
1968 and 2012. We suggest that these two structures support physiologically relevant
binding of H3N2 hemagglutinin and that this physiologically relevant binding has not
changed since the 1968 pandemic. Therefore binding changes did not contribute to
reduced severity of seasonal H3N2 viruses. This work will help direct the search for
factors enhancing influenza virulence.
Abrupt onset of tongue deformation and phase space response of ions in magnetically-confined plasmas
Authors: Ida K. , Kobayashi T. , Itoh K. , Yoshinuma M. , Tokuzawa T. , Akiyama T. , Moon C. , Tsuchiya H. , Inagaki S. , Itoh S.-I.
Published: October 2016

An abrupt onset of the new tongue-shaped deformation of magnetic surface in magnetized plasmas, which was conjectured in since the 1960s but has not been observed, is experimentally identified just before an abrupt onset of a large-scale collapse event. Two novel properties of the event are identified. First, the transition of symmetry of perturbation (rather than a growth of linearly unstable MHD modes) was found to be a key for the onset of abrupt collapse, i.e., the transition of symmetry gives a new route to the collapse from stable state. Second, as a phase-space response of ions, the distortion from Maxwell-Boltzmann distribution of epithermal ions was observed for the first time.
The Association between Impaired Glucose Regulation and Prognosis of Chinese Patients with Intracerebral Hemorrhage
Authors: Sun Shichao , Pan Yuesong , Zhao Xingquan , Liu Liping , Li Hao , He Yan , Guo Li , Wang Yilong , Wang Yongjun
Published: October 2016

This study aimed at observing the influence of impaired glucose regulation (IGR) on 1-year outcomes in patients with intracerebral hemorrhage (ICH). Patients hospitalized for ICH from 2008 to 2009 were recruited consecutively at 35 centres across China. A standard oral glucose tolerance test at day 14 ± 3 after stroke onset or before discharge was performed to identify IGR. The outcomes were death (modified Rankin scale [mRS] score of 6), dependency (mRS score of 2 to 5) and poor outcome (mRS score of 2 to 6) at 1 year. Cox proportion hazard model for death and logistic regression model for dependency and poor outcome were performed to investigate the influence of IGR on 1-year outcomes. A total of 288 non-diabetic ICH patients were included in this analysis, among which 150 (52.1%) were IGR. IGR was associated with 1-year dependency (adjusted odds ratio [OR] 2.18, 95% confidence interval [CI], 1.19–3.99; P = 0.01) and poor outcome (adjusted OR 2.17; 95% CI, 1.24–3.80; P = 0.007) of patients with ICH. However, IGR showed no significant association with 1-year death (adjusted hazard ratio 1.49, 95% CI, 0.60–3.67; P = 0.39). IGR was independently associated with 1-year poor outcome of ICH in Chinese patients, with more important influence on dependency than death.
Strontium inhibits titanium particle-induced osteoclast activation and chronic inflammation via suppression of NF-κB pathway
Authors: Zhu Shijun , Hu Xuanyang , Tao Yunxia , Ping Zichuan , Wang Liangliang , Shi Jiawei , Wu Xiexing , Zhang Wen , Yang Huilin , Nie Zhikui , Xu Yaozeng , Wang Zhirong , Geng Dechun
Published: October 2016

Wear-particle-induced chronic inflammation and osteoclastogenesis have been identified as critical factors of aseptic loosening. Although strontium is known to be involved in osteoclast differentiation, its effect on particle-induced inflammatory osteolysis remains unclear. In this study, we investigate the potential impact and underling mechanism of strontium on particle-induced osteoclast activation and chronic inflammation in vivo and in vitro. As expected, strontium significantly inhibited titanium particle-induced inflammatory infiltration and prevented bone loss in a murine calvarial osteolysis model. Interestingly, the number of mature osteoclasts decreased after treatment with strontium in vivo, suggesting osteoclast formation might be inhibited by strontium. Additionally, low receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor-α, interleukin-1β, interleukin-6 and p65 immunochemistry staining were observed in strontium-treatment groups. In vitro, strontium obviously decreased osteoclast formation, osteoclastogenesis-related gene expression, osteoclastic bone resorption and pro-inflammatory cytokine expression in bone-marrow-derived macrophages in a dose-dependent manner. Furthermore, we demonstrated that strontium impaired osteoclastogenesis by blocking RANKL-induced activation of NF-κB pathway. In conclusion, our study demonstrated that strontium can significantly inhibit particle-induced osteoclast activation and inflammatory bone loss by disturbing the NF-κB pathway, and is an effective therapeutic agent for the treatment of wear particle-induced aseptic loosening.
lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy
Authors: Li Xiangquan , Wang Hao , Yao Biao , Xu Weiting , Chen Jianchang , Zhou Xiang
Published: October 2016

We previously established a rat model of diabetic cardiomyopathy (DCM) and found that the expression of lncRNA H19 was significantly downregulated. The present study was designed to investigate the pathogenic role of H19 in the development of DCM. Overexpression of H19 in diabetic rats attenuated oxidative stress, inflammation and apoptosis, and consequently improved left ventricular function. High glucose was associated with reduced H19 expression and increased cardiomyocyte apoptosis. To explore the molecular mechanisms involved, we performed in vitro experiments using cultured neonatal rat cardiomyocytes. Our results showed that miR-675 expression was decreased in cardiomyocytes transfected with H19 siRNA. The 3′UTR of VDAC1 was cloned downstream of a luciferase reporter construct and cotransfected into HEK293 cells with miR-675 mimic. The results of luciferase assay indicated that VDAC1 might be a direct target of miR-675. The expression of VDAC1 was upregulated in cardiomyocytes transfected with miR-675 antagomir, which consequently promotes cellular apoptosis. Moreover, enforced expression of H19 was found to reduce VDAC1 expression and inhibit apoptosis in cardiomyocytes exposed to high glucose. In conclusion, our study demonstrates that H19/miR-675 axis is involved in the regulation of high glucose-induced apoptosis by targeting VDAC1, which may provide a novel therapeutic strategy for the treatment of DCM.
Single-Multiplex Detection of Organ Injury Biomarkers using SPRi based Nano-Immunosensor
Authors: Zeidan Effat , Li Siqi , Zhou Zhiguo , Miller Jennifer , Sandros Marinella G.
Published: October 2016

The clinical assessment of multiple organ dysfunctions at early stages is recognized to be an important factor in prompting definitive treatment decisions that prevent irreversible organ damage. In this article, we propose a real-time, label-free, and multiplex nanoenhanced SPRi platform to quantitatively assess two biomarkers, kidney injury molecule (KIM-1) and high mobility group box-1 (HMGB-1) simultaneously in buffer. Our work involves three major contributions in the design of the immunosensor: (1) we applied site-specific immobilization of antibodies to the solid surface that avoids loss of biological activity caused by covalent attachment; (2) we constructed a well-blocked sensor surface that exhibits minimal non-specific adsorption for singleplex measurements of each biomarker in buffer; and (3) we adopted a sandwich assay that implements functionalized quantum dots (NanoEnhancers) as signal amplifiers to achieve a sensitivity level of 5 pg/mL for KIM-1 and HMGB-1 in buffer. We foresee great potential and success in extending this multiplex and ultra-sensitive platform to assess a variety of other emerging clinical biomarkers at low concentrations and in complex matrices.
Preferential solvation and ion association properties in aqueous dimethyl sulfoxide solutions
Authors: Krishnamoorthy Anand Narayanan , Zeman Johannes , Holm Christian , Smiatek Jens
Published: October 2016

We study the solvation and association mechanism of an ion pair in aqueous DMSO solution. Our results verify a homoselective solvation behavior which can be related to strong non-ideal solution properties.
A new, double-inversion mechanism of the F− + CH3Cl SN2 reaction in aqueous solution
Authors: Liu Peng , Wang Dunyou , Xu Yulong
Published: October 2016

A new, double-inversion mechanism was discovered for the bimolecular nucleophilic substitution reaction F− + CH3Cl in aqueous solution.
Deprotonated guanine·cytosine and 9-methylguanine·cytosine base pairs and their “non-statistical” kinetics: a combined guided-ion beam and computational study
Authors: Lu Wenchao , Liu Jianbo
Published: October 2016

The intra-base-pair proton transfer and non-RRKM unimolecular kinetics of deprotonated guanine·cytosine base pairs.
Molecular logic gates based on benzo-18-crown-6 ether of styrylquinoline: a theoretical study
Authors: Tzeli Demeter , Petsalakis Ioannis D. , Theodorakopoulos Giannoula
Published: October 2016

Absorption and emission output of 1 can be utilized to build AND, NOR, XOR, XNOR, INHIBIT, and IMPLICATION logic gates.
Approaching the size limit of organometallic layers: synthesis and characterization of highly ordered silver–thiolate lamellae with ultra-short chain lengths
Authors: Ye Zichao , de la Rama Lito P. , Efremov Mikhail Y. , Zuo Jian-Min , Allen Leslie H.
Published: October 2016

Synthesis of single crystal silver alkanethiolate (any chain length) lamellae with highly ordered chain conformations, interlayer interfaces and intralayer lattices.
Control of clustering behavior in anionic cerium(iii) corrole complexes: from oligomers to monomers
Authors: Armstrong Keith C. , Hohloch Stephan , Lohrey Trevor D. , Zarkesh Ryan A. , Arnold John , Anstey Mitchell R.
Published: October 2016

Unusual clustering of lanthanide-corrole units has been found in the first reported examples of anion-capped lanthanide corrole complexes, and the degree of aggregation can be controlled by the choice of the capping ligand.
Organic–inorganic hybrid photocatalyst for carbon dioxide reduction
Authors: Won Dong-Il , Lee Jong-Su , Cheong Ha-Yeon , Cho Minji , Jung Won-Jo , Son Ho-Jin , Pac Chyongjin , Kang Sang Ook
Published: October 2016

Efficient hybrid photocatalysts for carbon dioxide reduction were developed from dye-sensitized TiO2 nanoparticles and their catalytic performance was optimized by ternary organic/inorganic components. Thus, the hybrid system consists of (E)-2-cyano-3-(5′-(5′′-(p-(diphenylamino)phenyl)thiophen-2′′-yl)thiophen-2′-yl)-acrylic acid as a sensitizer and fac-[Re(4,4′-bis(diethoxyphosphorylmethyl)-2,2′-bipyridine)(CO)3Cl] as a reduction catalyst (ReP), both of which have been fixed onto TiO2 semiconductors (s-TiO2, h-TiO2, d-TiO2). Mott–Schottky analysis on flat-band potential (Efb) of TiO2 mesoporous films has verified that Efb can be finely modulated by volume variation of water (0 to 20 vol%). The increase of added water resulted in substantial positive shifts of Efb from −1.93 V at 0 vol% H2O, to −1.74 V (3 vol% H2O), to −1.56 V (10 vol% H2O), and to −1.47 V (20 vol% H2O). As a result, with addition of 3–10 vol% water in the photocatalytic reaction, conversion efficiency of CO2 to CO increased significantly reaching a TON value of ∼350 for 30 h. Catalytic activity enhancement is mainly attributed to (1) the optimum alignment of Efb by 3–10 vol% water with respect to the of the dye and Ered of ReP for smooth electron transfer from photo-excited dye to RePvia the TiO2 semiconductor and (2) the water-induced acceleration of chemical processes on the fixed ReP. In addition, the energy level was further tuned by variation of the dye and ReP amounts. We also found that the intrinsic properties of TiO2 sources (morphology, size, agglomeration) exert a great influence on the overall photocatalytic activity of this hybrid system. Implications of the present observations and reaction mechanisms are discussed in detail.
Phytochemical profiles of marine phytoplanktons: an evaluation of their in vitro antioxidant and anti-proliferative activities
Authors: Huang Jim Jun-Hui , Xu Wen-Wen , Lin Shao-Ling , Cheung Peter Chi-Keung
Published: October 2016

Marine phytoplanktons are rich in bioactive components with antioxidant and anti-proliferative activities that can act as novel functional food ingredients.
A combination of natural deep eutectic solvents and microflow technology: a sustainable innovation for the tandem synthesis of 3-aminohexahydrocoumarins
Authors: Zamani Parisa , Khosropour Ahmad R.
Published: October 2016

A combination of natural deep eutectic solvents with microfluidic technology presents a powerful and attractive technique in the modern synthesis of fine chemicals.
A highly efficient metal-free approach to meta- and multiple-substituted phenols via a simple oxidation of cyclohexenones
Authors: Liang Yu-Feng , Song Song , Ai Lingsheng , Li Xinwei , Jiao Ning
Published: October 2016

The simple and readily available I2 catalyst, and a cheap and common DMSO oxidant could be employed for the transformation of cyclohexenones to meta- and multiple-substituted phenols with significant tolerance to various functional substituents.
Cement raw material quality analysis using laser-induced breakdown spectroscopy
Authors: Yin Hualiang , Hou Zongyu , Zhang Lei , Zhang Xiangjie , Wang Zhe , Li Zheng
Published: October 2016

The capability of LIBS analysis of the cement raw material is improved by using a new spectrum standardization method.
NBS/DBU mediated one-pot synthesis of α-acyloxyketones from benzylic secondary alcohols and carboxylic acids
Authors: Zhu Minghui , Wei Wei , Yang Daoshan , Cui Hong , Cui Huanhuan , Sun Xuejun , Wang Hua
Published: October 2016

A simple and efficient NBS/DBU-mediated one-pot procedure has been developed for the synthesis of α-acyloxyketones from benzylic secondary alcohols and carboxylic acids.
Total synthesis, structural elucidation and anti-inflammatory activity evaluation of 2-deoxy-3,6-anhydro hexofuranoside derivatives isolated from Sauropus rostratus
Authors: Zhang Chenxi , Wang Chengcheng , Wang Zihao , Tanabe Genzoh , Muraoka Osamu , Lin Aijun , Xu Jinyi , Wu Xiaoming , Wu Liang , Xie Weijia
Published: October 2016

The first total synthesis of four 2-deoxy-3,6-anhydro hexofuranoside derivatives isolated from Genus Sauropus rostratus was accomplished.
Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions
Authors: Hayakawa Ichiro , Saito Keita , Matsumoto Sachiko , Kobayashi Shinichi , Taniguchi Ayaka , Kobayashi Kenichi , Fujii Yusuke , Kaneko Takahiro , Kigoshi Hideo
Published: October 2016

Second-generation total synthesis of aplyronine A, a potent antitumor marine macrolide, was achieved using Ni/Cr-mediated coupling reactions as key steps.
Synthesis of a quinoidal dithieno[2,3-d;2′,3′-d]benzo[2,1-b;3,4-b′]-dithiophene based open-shell singlet biradicaloid
Authors: Xia Debin , Keerthi Ashok , An Cunbin , Baumgarten Martin
Published: October 2016

A fused heteroacene derivative, bis(dicyanomethylene)-end-capped-dithieno[2,3-d;2′,3′-d]benzo[2,1-b;3,4-b′]-dithiophene (4CN-DTmBDT) was synthesized.
Thermoelectric performance of conducting aerogels based on carbon nanotube/silver nanocomposites with ultralow thermal conductivity
Authors: Sun Xijing , Zhao Jinghong , Zhao Lijuan , Wu Jinrong , Li Quan
Published: October 2016

New conducting aerogels based on carbon nanotube (CNT) and silver (Ag) nanocomposites have been systematically investigated.
Radioprotective effects of ultra-small citrate-stabilized cerium oxide nanoparticles in vitro and in vivo
Authors: Popov A. L. , Zaichkina S. I. , Popova N. R. , Rozanova O. M. , Romanchenko S. P. , Ivanova O. S. , Smirnov A. A. , Mironova E. V. , Selezneva I. I. , Ivanov V. K.
Published: October 2016

Different radioprotective action mechanisms of CeO2 nanoparticles in vitro and in vivo are demonstrated and discussed.
A free-standing, flexible and bendable lithium-ion anode materials with improved performance
Authors: Zhang Xueqian , Huang Xiaoxiao , Zhang Yingfei , Xia Long , Zhong Bo , Zhang Xiaodong , Tian Nan , Zhang Tao , Wen Guangwu
Published: October 2016

Bendable, flexible and self-supported anode materials with excellent electrochemical properties have highly attractive for the high performance lithium-ion batteries (LIBs).
Mango kernel fat based chocolate fat with heat resistant triacylglycerols: production via blending using mango kernel fat mid-fraction and palm mid-fractions produced in different fractionation paths
Authors: Jin Jun , Warda Pembe , Qi Ce , Sun Cong , Jie Liang , Xie Dan , Huang Jianhua , Jin Qingzhe , Wang Xingguo
Published: October 2016

Heat resistance chocolate fats production using palm mid-fractions produced in different fractionation paths and mango kernel fats.
High performance tunable piezoresistive pressure sensor based on direct contact between printed graphene nanoplatelet composite layers
Authors: Mouhamad Y. , Mortensen T. , Holder A. , Lewis A. R. , Maffeis T. G. G. , Deganello D.
Published: October 2016

Screen printed pressure sensors based on direct contact of graphene nanoplatelets composite layers, with no intermediate physical gap, showed an effective piezoresistive response over a large force range.
One-pot synthesis of polydopamine–Zn complex antifouling coatings on membranes for ultrafiltration under harsh conditions
Authors: Wu Huiqing , Ang Jia Ming , Kong Junhua , Zhao Chenyang , Du Yonghua , Lu Xuehong
Published: October 2016

In this work, dopamine is polymerized in a basic aqueous solution that contains zinc species to form a hybrid coating on polysulfone (PSf) ultrafiltration membranes.
The reaction mechanism for highly effective hydrodechlorination of p-chlorophenol over a Pd/CNTs catalyst
Authors: Lan Lijuan , Du Fanglin , Xia Chuanhai
Published: October 2016

Different mass-transfer mechanisms of CNTs and AC for the HDC of p-CP.
Computational investigation of curcumin, a natural polyphenol that inhibits the destabilization and the aggregation of human SOD1 mutant (Ala4Val)
Authors: Srinivasan E. , Rajasekaran R.
Published: October 2016

Curcumin inhibits the aberrant aggregation in mutant SOD1 protein, thereby decreasing the propensity of β-sheets and the toxicity level.
Efficient non-catalytic oxidative and extractive desulfurization of liquid fuels using ionic liquids
Authors: Ahmed Omar U. , Mjalli Farouq S. , Al-Wahaibi Talal , Al-Wahaibi Yahya , AlNashef Inas M.
Published: October 2016

Oxidative desulfurization (ODS) is one of the promising alternative and heavily researched desulfurization technologies.
Acetyl salicylic acid–ZnAl layered double hydroxide functional nanohybrid for skin care application
Authors: Mosangi Damodar , Moyo Lumbidzani , Kesavan Pillai Sreejarani , Ray Suprakas Sinha
Published: October 2016

In this study, a pharmaceutically active ingredient, acetyl salicylic acid (ASA), was intercalated into ZnAl layered double hydroxide (LDH). The ASA–LDH-based cream showed its high prospects in curing skin disorders like razor bumps in a short span of time.
Li-ion storage in morphology tailored porous hollow Cu2O nanospheres fabricated by Ostwald ripening
Authors: Shilpa Shilpa , Rai Prabhakar , Sharma Ashutosh
Published: October 2016

In this work, morphology of Cu2O is tuned from solid to hollow nanospheres and their effect on Li storage is investigated.
p-Bromoaryl- and ω-bromoalkyl-VA-PNBs: suitable starting materials for the functionalization of vinylic addition polynorbornenes via palladium-catalyzed cross-coupling reactions
Authors: Martínez-Arranz Sheila , Sánchez-Pérez Eduardo , Molina de la Torre Jesús A. , Pérez-Ortega Ignacio , Albéniz Ana C.
Published: October 2016

New routes to functionalize the robust VA-polynorbornene skeleton by Pd-catalyzed cross-coupling reactions usep-bromoaryl- and ω-bromoalkyl-VA-PNBs as versatile starting materials.
Direct interfacial growth of MnO2 nanoparticles on carbon nanofiber surfaces for high-performance asymmetric supercapacitors
Authors: Zhao Chang-Feng , Lu Ke , Ma Houyi
Published: October 2016

Facile interfacial growth of MnO2 nanoparticles on carbon nanofibers (MnO2/CNF) and the application of this material as a high-performance positive electrode material in asymmetric supercapacitors are presented.
Synthesis of zeolite nanocrystals with intercrystal mesopores using an organosilane as the structure directing agent
Authors: Dai Jiqiang , Zhou Xiya , Chen Zhihang , Chen Dingsheng , Zeng Gai , Cen Chaoping
Published: October 2016

This study utilizes an applied approach to obtain novel ZMS-5 nanocrystals with mesoporosity using an organosilane as an additive.
Nanoarchitectures of self-assembled poly(styrene-b-4-vinyl pyridine) diblock copolymer blended with polypeptide for effective adsorption of mercury(ii) ions
Authors: Lu Yi-Syuan , Bastakoti Bishnu Prasad , Pramanik Malay , Hossain Md. Shahriar A. , Alshehri Saad M. , Yamauchi Yusuke , Kuo Shiao-Wei
Published: October 2016

The crosslinked PS-b-P4VP/PTyr materials possesses superior adsorbed mercur since mercury ions tend to bind to the pyridyl rings of P4VP and the amido groups of PTyr through ionic dipole interactions.
Synthesis and properties of polyurethane urea with pyridine-2,6-dicarboxamide moieties in their structure
Authors: Oprea S. , Potolinca V. O. , Varganici C.-D.
Published: October 2016

The inclusion of 2,6-pyridinedicarboxamide into polyurethanes structure strongly influenced their morphology, surface and thermo-mechanical properties. The 2,6-pyridinedicarboxamide units adoptsyn-synconformations into polyurethane matrix.
Sub-amorphous thermal conductivity in amorphous heterogeneous nanocomposites
Authors: Moon Jaeyun , Minnich Austin J.
Published: October 2016

Here, we use equilibrium molecular dynamics to show that an amorphous SiGe nanocomposite can possess thermal conductivity substantially lower than those of the amorphous Si and Ge constituents.
The electrochemical 4-chlorophenol sensing properties of a plasma-treated multilayer graphene modified photolithography patterned platinum electrode
Authors: Kannan Padmanathan Karthick , Gelamo Rogerio V. , Morgan Hywel , Suresh Palaniswamy , Rout Chandra Sekhar
Published: October 2016

The present work describes the electrochemical 4-chlorophenol (4-CP) sensing properties of oxygen plasma treated multilayer graphene samples (MLG).
One-step solid phase synthesis of a highly efficient and robust cobalt pentlandite electrocatalyst for the oxygen evolution reaction
Authors: Al-Mamun Mohammad , Wang Yun , Liu Porun , Zhong Yu Lin , Yin Huajie , Su Xintai , Zhang Haimin , Yang Huagui , Wang Dan , Tang Zhiyong , Zhao Huijun
Published: October 2016

One-step concurrent growth of a Co9S8/carbon nanosheet composite as an efficient and robust oxygen evolution electrocatalyst.
Three-dimensional hierarchical nickel–cobalt–sulfide nanostructures for high performance electrochemical energy storage electrodes
Authors: Li Zhenhu , Li Xu , Xiang Lu , Xie Xiong , Li Xue , Xiao Dong-Rong , Shen Jun , Lu Wenqiang , Lu Li , Liu Shuangyi
Published: October 2016

Novel 3D hierarchical holey (Co, Ni)3S2 nanostructures are fabricated and exhibit outstanding comprehensive performance as electrodes for electrochemical energy storage.
Sulfur-loaded monodisperse carbon nanocapsules anchored on graphene nanosheets as cathodes for high performance lithium–sulfur batteries
Authors: Park Seung-Keun , Lee Jeongyeon , Hwang Taejin , Piao Yuanzhe
Published: October 2016

A nanostructured material of sulfur-loaded monodisperse carbon nanocapsules anchored on a graphene nanosheet was prepared for application to Li–S batteries.
Alleviating polarization by designing ultrasmall Li2S nanocrystals encapsulated in N-rich carbon as a cathode material for high-capacity, long-life Li–S batteries
Authors: Hu Chenji , Chen Hongwei , Xie Yanping , Fang Liang , Fang Jianhui , Xu Jiaqiang , Zhao Hongbin , Zhang Jiujun
Published: October 2016

Lithium sulfide with a high theoretical specific capacity of 1166 mA h g−1, has potential application in cathodes because of its high safety and compatibility for Li–S batteries.
Chemical vapour deposition and characterization of uniform bilayer and trilayer MoS2crystals
Authors: Zobel Adam , Boson Alex , Wilson Peter M. , Muratov Dmitry S. , Kuznetsov Denis V. , Sinitskii Alexander
Published: October 2016

We report a chemical vapor deposition procedure for MoS2growth from MoO3and S, which yields predominantly bilayer and trilayer MoS2triangular islands.
New two-dimensional Mn-based MXenes with room-temperature ferromagnetism and half-metallicity
Authors: He Junjie , Lyu Pengbo , Nachtigall Petr
Published: October 2016

Magnetic properties of Mn2CT2 (T = F, Cl, OH, O, and H) MXenes are reported based on a computational investigation.
Correction: Investigation of plasmonic signal enhancement based on long range surface plasmon resonance with gold nanoparticle tags
Authors: Yang Chih-Tsung , Wu Lin , Bai Ping , Thierry Benjamin
Published: October 2016

Correction for ‘Investigation of plasmonic signal enhancement based on long range surface plasmon resonance with gold nanoparticle tags’ by Chih-Tsung Yang et al., J. Mater. Chem. C, 2016, 4, 9897–9904.
New approach to design SVC‐based stabiliser using genetic algorithm and rough set theory
Authors: Fetouh Tamer , Zaky Mohamed S.
Published: October 2016

A new approach for coordinated design of a static VAR compensator‐based stabiliser and a conventional power system stabiliser is proposed. The approach is based on the integration between genetic algorithm (GA) and rough‐set theory. The role of rough set is to select the most dominant controller parameters that are involved in the optimisation process. The proposed approach aims to minimise the computational time and reduce the storage capacity required for the optimisation problem as well as improve the performance of power system stability of power system. The proposed rough‐set‐based GA is applied to select the controller parameters included in the optimisation process as well as search for their optimal setting. This study also presents a comparison between the system performances when utilising individual or coordinated controllers with those of system utilising the proposed approach. Single machine system is used to investigate the efficacy of the proposed approach and multi‐machine system is used to demonstrate the applicability and scalability of the proposed method. The simulation results and comparison analysis show the effectiveness of the rough‐set‐based GA. In addition, a good reduction in optimisation time and size of information is achieved by applying the rough‐set‐based GA.
Introduction
Authors: David-Claude Kemo Keimbou , Emmanuel Claude Abolo Biwole , Maurice Enama
Published: October 2016

Depuis le début des années 2010, on « commémore » le cinquantenaire des indépendances des pays d'Afrique noire francophone, de leurs armées, de leurs universités et grandes écoles, mais aussi de leur sport et mouvement sportif.
Politique juridique et diplomatie sportive du Cameroun de 1960 à nos jours : enjeux et mutations à l'ère de la mondialisation
Authors: Jabea Claude Bekombo
Published: October 2016

Si l'organisation de ce qu'on peut appeler la communauté sportive internationale est structurée autour du « corporatisme sportif », les Etats, eux, sont marqués par la prégnance de la dualité « territoire » et « souveraineté ». C'est sous ce fondement binaire que l'Etat légifère sur le sport, on parle de politique juridique sportive et utilise le sport comme élément de sa diplomatie, on parle de diplomatie sportive.

L'intérêt de cette étude est d'identifier les éléments constitutifs de la politique juridique et de la diplomatie sportive du Cameroun et In fine de donner des éléments permettant d'en parler de depuis l'indépendance.
Perception de la notion de litige sportif par les acteurs du mouvement sportif camerounais : entre et lueurs et leurres
Authors: Romuald Dey Yelem Franck
Published: October 2016

Depuis sa création en 2001, la Chambre de Conciliation et d'Arbitrage (CCA) du Comité National Olympique et Sportif du Cameroun (CNOSC) n'avait jamais connu une aussi grande sollicitation en l'espace de quelques mois. En effet, la loi n∘ 2011/018 du 15 juillet 2011 relative à l'organisation et à la promotion des Activités Physiques et Sportives au Cameroun a davantage confirmé la place de cette juridiction sportive nationale au cœur du contentieux dans le domaine du sport.

La Chambre de conciliation et d'arbitrage est la seule juridiction sportive reconnue, au niveau national, par les lois camerounaises et aucune équivoque n'est levée dans cette loi sur la qualification du litige à soumettre devant la Chambre. Elle est compétente pour tous les litiges sportifs. Peut-être faudrait-il marquer un arrêt sur la notion de « litige sportif ». Si un contentieux électoral, au sein d'une fédération sportive, n'est pas un litige sportif, qu'elle est alors la nature d'un tel litige. Un tel litige n'est, ni commercial, ni politique, ni culturel, ni agricole. Il ne peut être que sportif, et de ce fait, relève de la compétence de la seule juridiction sportive légalement instituée.

L'intérêt de cette communication sera de donner le contenu des notions de litige sportif et contentieux électoral et les différentes positions en présence et voir comment les acteurs du mouvement sportif en ont fait une appréhension erronée. Il va aussi permettre à travers la jurisprudence qui est source de droit de trancher définitivement cette équivoque.
Le règlement des litiges sportifs devant la Chambre de Conciliation et d'Arbitrage – CCA CNOSC
Authors: Charles Tchatchouang M.
Published: October 2016

Au cours de l'année 2011, un grand tournant de l'histoire du mouvement sportif camerounais a été marqué par l'adoption et la promulgation de la loi n∘ 2011/018 du 15 juillet 2011 relative à l'organisation et à la promotion des Activités Physiques et Sportives (A.P.S) au Cameroun. Cette loi qui abroge totalement celle n∘ 96/09 du 5 août 1996 fixant la Charte des APS illustre la volonté du législateur de réorganiser et de promouvoir ces activités au Cameroun. Elle vient en outre conforter la place de l'instrument juridique universel du mouvement sportif qu'est la Charte Olympique, laquelle institue des organes juridictionnels au sein des Comités Nationaux Olympiques (CNO). C'est la raison pour laquelle dans cette réorganisation, la Chambre de Conciliation et d'Arbitrage (CCA) occupe une place de choix. Plus qu'avant, plusieurs dispositions de ladite loi sont représentatives de cette affirmation.

Cette évolution juridique met un terme aux atermoiements affichés ou exprimés par certains membres du mouvement sportif camerounais qui de bonne ou de mauvaise foi, contestaient la légitimité et la compétence de la CCA.

L'intérêt de ce travail importe plus que jamais de présenter une vue d'ensemble des différentes mutations juridiques ayant marqué l'histoire de la Chambre de Conciliation et d'Arbitrage du Comité National Olympique et Sportif du Cameroun.
Football et unité nationale : entre construction politique et signification sociale (1965–2010)
Authors: Nassir Abdoun
Published: October 2016

Au Cameroun, pays d'Afrique centrale qui compte plus de 200 langues nationales et entités ethniques, le football s'est imposé tant dans le discours politique que dans la praxis sociale comme un instrument de l'unité nationale. Sport le plus important au regard du palmarès et de l'engouement populaire, le football est un reflet pertinent de la dynamique historique qui s'opère dans ce pays. A l'image des clubs mythiques à base ethno-centrée qui ont animé la scène sportive du continent dans les décennies des années 60 et 70, la société semble s'attacher au marquage identitaire propre à ces associations sportives. C'est avec l'émergence du label « Lions indomptables » que nous assistons à un véritable mixage à l'échelle nationale. Dans une approche dynamique, il s'agit de déterminer les fondements de cette unité rendue opérationnelle par le football. L'approche est éminemment pluridisciplinaire en usant de l'histoire, de la science politique et de la sociologie.
Le mouvement olympique et les droits de l'homme
Authors: Enama Maurice
Published: October 2016

L'histoire de l'olympisme moderne est traversée par la préoccupation lancinante et permanente du respect des droits de l'homme. Cela est heureux. En effet, les valeurs que véhicule l'olympisme sont peu ou prou « filles » des droits de l'homme, dans la mesure où ces valeurs puisent dans l'humanisme et dans l'universel.

L'Olympisme poursuit l'épanouissement total de l'individu pour une société plus ouverte, les Droits de l'Homme visent pour leur part la dignité l'Homme dans une société plus juste. Leur rapprochement paraît donc naturel dans une société humaine en proie aux égoïsmes, aux inégalités, aux discriminations de tous genres, en un mot à des forces négatrices et régressives.

L'Idéal olympique s'inscrit explicitement dans la perspective dessinée par la Convention Universelle des Droits de l'Homme. Les Droits de l'Homme sont ici pris dans leur aspect philosophique, tels qu'ils ont été théorisés par le juriste hongrois Alexandre-Charles Kiss (1991). Ils sont fondés sur le principe éthique de l' « égale dignité », cette expression elle-même empruntée au théoricien du droit Britannique Ronald Dworkin (1977). Avec ce principe les deux pendants de la dignité se rejoignent : la liberté positive qui représente la capacité pour chaque individu de décider de ce qui politiquement et socialement vaut pour l'homme et la liberté négative qui est celle de faire ce qui ne nuit pas à autrui. Ainsi donc, le principe « d'égale dignité » apparaît clairement comme la matrice de l'Olympisme et des Droits de l'Homme, même si ces dernières ont un spectre plus large.
Excess electrons in methanol clusters: Beyond the one-electron picture
Authors: Pohl Gábor , Mones Letif , Turi László
Published: October 2016

We performed a series of comparative quantum chemical calculations on various size negatively charged methanol clusters, CH3OHn−. The clusters are examined in their optimized geometries (n = 2–4), and in geometries taken from mixed quantum-classical molecular dynamics simulations at finite temperature (n = 2–128). These latter structures model potential electron binding sites in methanol clusters and in bulk methanol. In particular, we compute the vertical detachment energy (VDE) of an excess electron from increasing size methanol cluster anions using quantum chemical computations at various levels of theory including a one-electron pseudopotential model, several density functional theory (DFT) based methods, MP2 and coupled-cluster CCSD(T) calculations. The results suggest that at least four methanol molecules are needed to bind an excess electron on a hydrogen bonded methanol chain in a dipole bound state. Larger methanol clusters are able to form stronger interactions with an excess electron. The two simulated excess electron binding motifs in methanol clusters, interior and surface states, correlate well with distinct, experimentally found VDE tendencies with size. Interior states in a solvent cavity are stabilized significantly stronger than electron states on cluster surfaces. Although we find that all the examined quantum chemistry methods more or less overestimate the strength of the experimental excess electron stabilization, MP2, LC-BLYP, and BHandHLYP methods with diffuse basis sets provide a significantly better estimate of the VDE than traditional DFT methods (BLYP, B3LYP, X3LYP, PBE0). A comparison to the better performing many electron methods indicates that the examined one-electron pseudopotential can be reasonably used in simulations for systems of larger size.
A novel piezoelectrically actuated 2-DoF compliant micro/nano-positioning stage with multi-level amplification
Authors: Zhu Wu-Le , Zhu Zhiwei , Shi Yi , Chen Xiangfan , He Yu , Ehmann Kornel F. , Ju Bing-Feng
Published: October 2016

This article presents a novel two-degrees-of-freedom (2-DoF) piezo-actuated parallel-kinematic micro/nano-positioning stage with multi-level amplification. The mirror symmetric stage consists of four leverage mechanisms, two Scott-Russell mechanisms, and a Z-shaped flexure hinge (ZFH) mechanism. Taking advantage of the ZFH mechanism, 2-DoF motions with final-level flexural amplification and decoupled motion guidance are achieved. Analytical models of the stage are developed and validated through finite element analysis to characterize its working performance. Practical testing of a prototype stage is conducted to demonstrate the design process and to quantify its response characteristics. Due to the utilized multi-level amplification, a practical amplification ratio of 13.0 is realized by the prototype. The decoupled output motion guidance feature of the stage makes it amenable for implementation in raster scanning type of measurements.
Acoustic streaming and thermal instability of flow generated by ultrasound in a cylindrical container
Authors: Green Adam , Marshall Jeffrey S. , Ma Dong , Wu Junru
Published: October 2016

A vertically orientated ultrasonic transducer contained within a closed cylindrical Pyrex tube was used to study the acoustic streaming flow within a cylindrical container. A particle-image velocimetry (PIV) system incorporating fluorescent 1.5 μm seeding particles suspended in a mixture of diethyl-phthalate and ethanol, whose optical index was matched to that of Pyrex, was used to allow for undistorted PIV imaging within the Pyrex tube. Temperature on the end-wall surface and acoustic pressure within the cylinder were measured for different end-wall materials. Variables considered included acoustic absorption and reflection coefficients, ultrasound intensity, container height, and thermal properties of the end-wall material. It was observed that a quasi-steady flow field driven by acoustic streaming is rapidly established within the container, which is typically dominated by a stationary vortex ring with downward flow along the ring axis. After sufficient time this quasi-stationary flow exhibits a thermal instability causing it to transform into a secondary flow state. Different types of secondary flow states were observed, including cases where the flow along the cylinder axis is oriented upward toward the ultrasound transducer and cases where the axial flow changes directions along the cylinder axis.
Effective representation of amide III, II, I, and A modes on local vibrational modes: Analysis of ab initio quantum calculation results
Authors: Hahn Seungsoo
Published: October 2016

The Hamiltonian matrix for the first excited vibrational states of a protein can be effectively represented by local vibrational modes constituting amide III, II, I, and A modes to simulate various vibrational spectra. Methods for obtaining the Hamiltonian matrix from ab initio quantum calculation results are discussed, where the methods consist of three steps: selection of local vibrational mode coordinates, calculation of a reduced Hessian matrix, and extraction of the Hamiltonian matrix from the Hessian matrix. We introduce several methods for each step. The methods were assessed based on the density functional theory calculation results of 24 oligopeptides with four different peptide lengths and six different secondary structures. The completeness of a Hamiltonian matrix represented in the reduced local mode space is improved by adopting a specific atom group for each amide mode and reducing the effect of ignored local modes. The calculation results are also compared to previous models using C=O stretching vibration and transition dipole couplings. We found that local electric transition dipole moments of the amide modes are mainly bound on the local peptide planes. Their direction and magnitude are well conserved except amide A modes, which show large variation. Contrary to amide I modes, the vibrational coupling constants of amide III, II, and A modes obtained by analysis of a dipeptide are not transferable to oligopeptides with the same secondary conformation because coupling constants are affected by the surrounding atomic environment.