bluuebunny/crossref_metadata_2025 huggingface dataset:
Cell Heterogeneity and Variability in Peripheral Nerve after Injury
Authors: Ren Zhixian , Tan Ya , Zhao Lili
Published: March 2024

With the development of single-cell sequencing technology, the cellular composition of more and more tissues is being elucidated. As the whole nervous system has been extensively studied, the cellular composition of the peripheral nerve has gradually been revealed. By summarizing the current sequencing data, we compile the heterogeneities of cells that have been reported in the peripheral nerves, mainly the sciatic nerve. The cellular variability of Schwann cells, fibroblasts, immune cells, and endothelial cells during development and disease has been discussed in this review. The discovery of the architecture of peripheral nerves after injury benefits the understanding of cellular complexity in the nervous system, as well as the construction of tissue engineering nerves for nerve repair and axon regeneration.
Flow Cytometry Analysis in Breast Implant-Associated Anaplastic Large Cell Lymphoma: Three Case Reports
Authors: Davanzo Veronica , Falda Alessandra , Fogar Paola , Ludwig Kathrin , Zuin Jenny , Toffanin Maria Cristina , Pizzi Marco , Dei Tos Angelo Paolo , Basso Daniela
Published: March 2024

Breast Implant-Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL) is a rare T-cell non-Hodgkin lymphoma associated with breast prosthetic implants and represents a diagnostic challenge. The National Comprehensive Cancer Network (NCCN) guidelines, updated in 2024, recommend for diagnosis an integrated work-up that should include cell morphology, CD30 immunohistochemistry (IHC), and flow cytometry (FCM). CD30 IHC, although the test of choice for BIA-ALCL diagnosis, is not pathognomonic, and this supports the recommendation to apply a multidisciplinary approach. A close collaboration between pathologists and laboratory professionals allowed the diagnosis of three BIA-ALCLs, presented as case reports, within a series of 35 patients subjected to periprosthetic effusions aspiration from 2018 to 2023. In one case, rare neoplastic cells were identified by FCM, and this result was essential in leading the anatomopathological picture as indicative of this neoplasm. In fact, the distinction between a lymphomatous infiltrate from reactive cells may be very complex in the cytopathology and IHC setting when neoplastic cells are rare. On the other hand, one limitation of FCM analysis is the need for fresh samples. In this study, we provide evidence that a dedicated fixative allows the maintenance of an unaltered CD30 expression on the cell surface for up to 72 h.
Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics
Authors: Pyrak Bartłomiej , Rogacka-Pyrak Karolina , Gubica Tomasz , Szeleszczuk Łukasz
Published: March 2024

Cyclodextrin-based nanosponges (CDNSs) are complex macromolecular structures composed of individual cyclodextrins (CDs) and nanochannels created between cross-linked CD units and cross-linkers. Due to their unique structural and physicochemical properties, CDNSs can possess even more beneficial pharmaceutical features than single CDs. In this comprehensive review, various aspects related to CDNSs are summarized. Particular attention was paid to overviewing structural properties, methods of synthesis, and physicochemical analysis of CDNSs using various analytical methods, such as DLS, PXRD, TGA, DSC, FT-IR, NMR, and phase solubility studies. Also, due to the significant role of CDNSs in pharmaceutical research and industry, aspects such as drug loading, drug release studies, and kinetics profile evaluation of drug–CDNS complexes were carefully reviewed. The aim of this paper is to find the relationships between the physicochemical features and to identify crucial characteristics that are influential for using CDNSs as convenient drug delivery systems.
Short-Term Mortality in Hospitalized Patients with Congestive Heart Failure: Markers of Thrombo-Inflammation Are Independent Risk Factors and Only Weakly Associated with Renal Insufficiency and Co-Morbidity Burden
Authors: Iglesias Jose , Okoh Nelson , Ang Song Peng , Rodriguez Cristina A. , Chia Jia Ee , Levine Jerrold S.
Published: March 2024

Congestive heart failure (CHF) is associated with significant morbidity and mortality. There has been renewed interest in using thrombo-inflammatory markers as prognostic tools in patients with CHF. To determine if thrombo-inflammatory markers are independent risk factors for 28-day mortality in hospitalized CHF patients, we retrospectively analyzed admission data extracted from 2008 consecutive patients admitted with a diagnosis of CHF to Zigong Fourth People’s Hospital. Multivariate Cox proportional hazards analysis demonstrated that the thrombo-inflammatory markers thrombin time, platelet/lymphocyte ratio (PLR), and D-dimer level were independent predictors of mortality. In addition, variables reflecting the severity of CHF (New York Heart Association class > 2), impaired renal function (elevated serum creatinine [SCr]), impaired organ perfusion (elevated BUN), and chronic liver disease were also independent predictors of mortality. Thrombo-inflammatory biomarkers were only weakly associated with SCr and the burden of co-morbidity, suggesting that thrombo-inflammation may in large part be attributable to CHF itself and that, moreover, its presence may confer an increased risk of mortality. Further large-scale prospective studies are needed to determine the existence and the consequences of a thrombo-inflammatory phenotype among patients with CHF.
Tongue-in-Groove: A Novel Implant Design for a Blow-Out Fracture
Authors: Byeon Je-Yeon , Hwang Yong-Seon , Choi Hwan-Jun , Lee Da-Woon , Kim Jun-Hyuk
Published: March 2024

Background: During blow-out fracture surgery, restoration of the orbital volume and rigid implant fixation are essential. The migration of an implant is a concern of most surgeons. The purpose of this study was to introduce a simple idea of molding and fixing an orbital implant. Methods: In the tongue-in-groove method, an incision of about 2 mm was made on the edge of the implant and it was bent to form a slot. A hole was made in the center of the implant for fitting a bone hook, and the implant was firmly fit into the remaining intact bone. Before and after surgery, computed tomography (CT) was used to evaluate changes in the orbital volume and the location of the implant. Statistically significant restoration of the orbital volume was confirmed on postoperative CT. Results: Compared with the unaffected orbital volume, the affected orbital volume was increased from 87.06 ± 7.92% before surgery to 96.14 ± 6.11% after surgery (p < 0.001). There was one case of implant migration during follow-up. However, the degree of movement was not severe, and there were no events during the follow-up period. Conclusions: The tongue-in-groove technique offers advantages, such as easy fixation of the implant, with minimal trauma to the surrounding tissues. In addition, the method offers advantages, such as being easy to learn, requiring little time for trimming the implant, and being relatively low cost. Therefore, it can be one of the options for implant fixation.
Ictal Bradycardia and Asystole in Sleep-Related Hypermotor Epilepsy: A Study of 200 Patients
Authors: Muccioli Lorenzo , Bruschi Giulia , Ferri Lorenzo , Scarabello Anna , Taruffi Lisa , Di Vito Lidia , Mostacci Barbara , Provini Federica , Calandra-Buonaura Giovanna , Tinuper Paolo , Licchetta Laura , Bisulli Francesca
Published: March 2024

Background: Ictal bradycardia (IB) and asystole (IA) represent a rare but potentially harmful feature of epileptic seizures. The aim of this study was to study IB/IA in patients with sleep-related hypermotor epilepsy (SHE). Methods: We retrospectively included cases with video-EEG-confirmed SHE who attended our Institute up to January 2021. We reviewed the ictal polysomnography recordings focusing on ECG and identified cases with IB (R-R interval ≥ 2 s or a ≥10% decrease of baseline heart rate) and IA (R-R interval ≥ 4 s). Results: We included 200 patients (123 males, 61.5%), with a mean age of 42 ± 16 years. Twenty patients (20%) had focal cortical dysplasia (FCD) on brain MRI. Eighteen (out of 104 tested, 17.3%) carried pathogenic variants (mTOR pathway, n = 10, nAchR subunits, n = 4, KCNT1, n = 4). We identified IB/IA in four cases (2%): three had IA (mean 10 s) and one had IB. Three patients had FCD (left fronto-insular region, left amygdala, right mid-temporal gyrus) and two had pathogenic variants in DEPDC5; both features were more prevalent in patients with IB/IA than those without (p = 0.003 and p = 0.037, respectively). Conclusions: We identified IB/IA in 2% of patients with SHE and showed that this subgroup more frequently had FCD on brain MRI and pathogenic variants in genes related to the mTOR pathway.
Children Intoxicated with Psychoactive Substances: The Health Status on Admission to Hospital Based on Medical Records
Authors: Kosiorek Dorota , Lewko Jolanta , Romankiewicz Ewa
Published: March 2024

Introduction: Alcohol is the most common psychoactive substance among young people. The use of psychoactive substances gives rise to a number of health, social, moral and economic problems. The aim of the study was to characterise the symptoms reported by children and adolescents presenting with psychoactive substance intoxication on admission to hospital. Methods: The study included a group of 303 patients aged 0 to 18 years, diagnosed with psychoactive substance intoxication. This retrospective study assessed medical records of patients hospitalised at the Provincial Specialist Children’s Hospital in Olsztyn between 2016 and 2018. Results: Body temperature on admission varied depending on the type of psychoactive substance taken (χ2 = 14.12, p < 0.006). Girls were more likely to have an increased heart rate than boys. An analysis of the symptoms of intoxication over the years 2016–2018 showed significant differences in the incidence of the following symptoms: disturbed consciousness (χ2 = 8.75, p < 0.01), visual disorders (χ2 = 8.02, p < 0.02), loss of consciousness (χ2 = 37.71, p < 0.000001), drowsiness (χ2 = 7.33, p < 0.03), hypothermia (χ2 = 18.95, p < 0.00008) and gait disturbances (χ2 = 13.08, p < 0.002). Conclusions: Girls are more likely to use stimulants such as alcohol and cigarettes, while boys are more likely to opt for designer drugs. The number of patients hospitalised more than once increases every year. Gastrointestinal intoxication with psychoactive substances was most common. The most severe intoxication was associated with alcohol intake, while the most intense pain was reported by patients poisoned with other psychoactive substances.
Peripartum Depressive Symptoms in Fathers during the COVID-19 Pandemic
Authors: Cimino Silvia , Cerniglia Luca
Published: March 2024

Background: This research investigates peripartum depression in fathers during COVID-19, focusing on how pandemic-related distress is associated with paternal depressive symptoms and the quality of father–child feeding interactions. The primary objective was to understand if the pandemic has influenced depressive symptoms in new fathers and how these symptoms impact their interactions with their children, especially during feeding. Methods: Utilizing a cross-sectional design, the research employs online surveys and remote observation to gather data from 243 Italian fathers. The analysis involves established psychometric tools like the Symptoms Check-List/90R and the Peritraumatic Distress Index to assess the severity of depressive symptoms and their correlation with father–child interaction exchanges, observed through the SVIA. Results: The fathers’ peritraumatic distress due to COVID-19 was significantly and positively associated with the level of their depressive symptoms and negatively correlated with the quality of their feeding interactions with their children. Moreover, elevated levels of peritraumatic stress were notably predictive of higher instances of depressive symptoms in the fathers. Further, higher levels of stress associated with COVID-19 were predictive of a poorer quality of father–child interactions. Conclusions: This research highlights the need for inclusive perinatal support programs, offering foundational insights into paternal mental health during pandemics.
The sFlt-1/PlGF Ratio at 12, 24, and 32 Weeks Gestation in Twin Pregnancies as a Predictor of Placental Dysfunction
Authors: Satorres-Pérez Elena , Martínez-Varea Alicia , Novillo-Del Álamo Blanca , Morales-Roselló José , Diago-Almela Vicente
Published: March 2024

Background: This study aims to assess the utility of the sFlt-1/PlGF ratio throughout pregnancy in predicting placental dysfunction and neonatal outcomes in twin pregnancies. Methods: Prospective study at a tertiary hospital. All pregnant women with a twin pregnancy who signed the informed consent were included. The sFlt-1/PlGF ratio was measured at 12, 24, and 32 weeks’ gestation. Results: Seventy patients were included, and 30% developed placental dysfunction. Differences were found in the mean sFlt-1/PlGF ratios at week 32 (13.6 vs. 31.8, p = 0.007). Optimal cutoffs at 12, 24, and 32 weeks to identify patients who develop placental dysfunction were 32.5, 8.5, and 30.5, respectively, with ORs of 4.25 (1.13–20.69 95% IC; p = 0.044), 13.5 (3.07–67.90 95% IC; p = 0.001), 14.29 (3.59–66.84 95% IC; p < 0.001). The sFlt-1/PlGF ratio at 32 weeks was associated with gestational age at birth. The sFlt-1/PlGF ratio in weeks 24 and 32 had a statistically significant negative correlation with the birth weight percentile in both twins. Conclusions: The potential of the sFlt-1/PlGF ratio as a predictive tool for placental dysfunction in twin pregnancies is underscored.
An Interpretable Machine Learning Framework for Rare Disease: A Case Study to Stratify Infection Risk in Pediatric Leukemia
Authors: Al-Hussaini Irfan , White Brandon , Varmeziar Armon , Mehra Nidhi , Sanchez Milagro , Lee Judy , DeGroote Nicholas P. , Miller Tamara P. , Mitchell Cassie S.
Published: March 2024

Background: Datasets on rare diseases, like pediatric acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), have small sample sizes that hinder machine learning (ML). The objective was to develop an interpretable ML framework to elucidate actionable insights from small tabular rare disease datasets. Methods: The comprehensive framework employed optimized data imputation and sampling, supervised and unsupervised learning, and literature-based discovery (LBD). The framework was deployed to assess treatment-related infection in pediatric AML and ALL. Results: An interpretable decision tree classified the risk of infection as either “high risk” or “low risk” in pediatric ALL (n = 580) and AML (n = 132) with accuracy of ∼79%. Interpretable regression models predicted the discrete number of developed infections with a mean absolute error (MAE) of 2.26 for bacterial infections and an MAE of 1.29 for viral infections. Features that best explained the development of infection were the chemotherapy regimen, cancer cells in the central nervous system at initial diagnosis, chemotherapy course, leukemia type, Down syndrome, race, and National Cancer Institute risk classification. Finally, SemNet 2.0, an open-source LBD software that links relationships from 33+ million PubMed articles, identified additional features for the prediction of infection, like glucose, iron, neutropenia-reducing growth factors, and systemic lupus erythematosus (SLE). Conclusions: The developed ML framework enabled state-of-the-art, interpretable predictions using rare disease tabular datasets. ML model performance baselines were successfully produced to predict infection in pediatric AML and ALL.
Impact of Prosthetic Material and Restoration Type on Peri-Implant Bone Resorption: A Retrospective Analysis in a Romanian Sample
Authors: Sabău Denisa Tabita , Juncar Raluca Iulia , Moca Abel Emanuel , Bota Teofana , Moca Rahela Tabita , Juncar Mihai
Published: March 2024

Background/Objectives: This research investigates the nuanced factors influencing peri-implant bone resorption in implant-supported fixed prostheses, with a focus on age, gender, implant location, time since prosthetic loading, and material characteristics. Methods: Records from a dental clinic in Oradea, Romania, between 1 January 2017 and 1 January 2023, were scrutinized and were selected by means of purposive sampling. All records were analyzed between 1 May 2023 and 15 June 2023. A total of 160 implants were included, and the prosthetic restorations were either metal-ceramic or zirconia. Implants from a single manufacturer were used, and a standardized loading protocol was followed. The study examined variables such as age, gender, implant location, prosthetic material, and time since prosthetic loading. Results: A total of 160 implants were included, with 78 applied to female patients (48.8%) and 82 to male patients (51.2%). The age range of the patients undergoing dental implant procedures was 30 to 79 years. Implants were distributed between the mandible (51.2%) and maxilla (48.8%), with 49.4% placed in the posterior dental arches and 50.6% in the anterior dental arches. The majority of patients received metal-ceramic prosthetic reconstructions (76.9%). Statistical analysis revealed significant differences in resorption patterns between zirconia and metal-ceramic restorations (p < 0.001), with zirconia restorations exhibiting higher resorption in the mesial-vertical and distal-vertical planes compared to metal-ceramic restorations. Age-related factors showed a significant association with distal-vertical resorption (p = 0.017), with patients aged 60–69 years exhibiting higher resorption values compared to those aged 40–49 years. Gender differences were observed in mesial-horizontal resorption (p = 0.036), with male patients displaying higher resorption values compared to female patients. Implant location and time elapsed since implant loading did not show significant associations with resorption patterns. Conclusions: The study provides insights into the multifactorial nature of peri-implant resorption. Age, gender, and material characteristics contribute to variations, informing personalized treatment approaches. The findings facilitate a comprehensive understanding for clinicians, enhancing treatment planning and post-operative care.
Robotic-Assisted versus Laparoscopic Surgery for Rectal Cancer: An Analysis of Clinical and Financial Outcomes from a Tertiary Referral Center
Authors: Gebhardt Jasper Max , Werner Neno , Stroux Andrea , Förster Frank , Pozios Ioannis , Seifarth Claudia , Schineis Christian , Weixler Benjamin , Beyer Katharina , Lauscher Johannes Christian
Published: March 2024

Background: The popularity of robotic-assisted surgery for rectal cancer is increasing, but its superiority over the laparoscopic approach regarding safety, efficacy, and costs has not been well established. Methods: A retrospective single-center study was conducted comparing consecutively performed robotic-assisted and laparoscopic surgeries for rectal cancer between 1 January 2016 and 31 September 2021. In total, 125 adult patients with sporadic rectal adenocarcinoma (distal extent ≤ 15 cm from the anal verge) underwent surgery where 66 were operated on robotically and 59 laparoscopically. Results: Severe postoperative complications occurred less frequently with robotic-assisted compared with laparoscopic surgery, as indicated by Clavien–Dindo classification grades 3b–5 (13.6% vs. 30.5%, p = 0.029). Multiple logistic regression analyses after backward selection revealed that robotic-assisted surgery was associated with a lower rate of total (Clavien–Dindo grades 1–5) (OR = 0.355; 95% CI 0.156–0.808; p = 0.014) and severe postoperative complications (Clavien–Dindo grades 3b–5) (OR = 0.243; 95% CI 0.088–0.643; p = 0.005). Total inpatient costs (median EUR 17.663 [IQR EUR 10.151] vs. median EUR 14.089 [IQR EUR 12.629]; p = 0.018) and surgery costs (median EUR 10.156 [IQR EUR 3.551] vs. median EUR 7.468 [IQR EUR 4.074]; p < 0.0001) were higher for robotic-assisted surgery, resulting in reduced total inpatient profits (median EUR −3.196 [IQR EUR 9.101] vs. median EUR 232 [IQR EUR 6.304]; p = 0.004). Conclusions: In our study, robotic-assisted surgery for rectal cancer resulted in less severe and fewer total postoperative complications. Still, it was associated with higher surgery and inpatient costs. With increasing experience, the operative time may be reduced, and the postoperative recovery may be further accelerated, leading to reduced surgery and total inpatient costs.
Effects of Premature Ventricular Complex Burden on Left Ventricular Global Longitudinal Strain in Patients without Structural Heart Disease
Authors: Sukru Arslan , Ozan Arabaci H. , Furkan Deniz M. , Emin Gokce M. , Seyma Arslan , Veysel Oktay , Mustafa Yıldız , Isıl Uzunhasan
Published: March 2024

Background: Evaluation of left ventricular (LV) function in patients with idiopathic premature ventricular contraction (PVC) with preserved LV ejection fraction (LVEF), especially in the subclinical stage, may be of great importance in terms of directing early treatment. Methods: A total of 122 patients, retrospectively recruited, were divided into three groups according to PVC burden: Group 1; 5% ≤ PVC < 10%, Group 2; 10% ≤ PVC < 15%, and Group 3; 15% ≤ PVC. Transthoracic echocardiography (TTE) was performed to evaluate LV parameters. Results: LV-GLS (Global longitudinal strain) was found to be significantly lower in groups 2 and 3 with high PVC burden (18.9% ± 1.4, 17.5% ± 2.1, 16.3% ± 1.3; p < 0.001, respectively). Correlation analysis revealed a positive and significant correlation between PVC burden and deterioration in LV-GLS (r: 0.536; p < 0.001). In addition, PVC burden was found to be an independent predictor of LV-GLS deterioration in multiple linear regression analysis (β: 0.525, p < 0.001). The ROC curve analysis demonstrated that a PVC burden cut-off value of 8.4% was associated with a LV-GLS deterioration greater than −18, with a specificity of 75.4% and a sensitivity of 75.4% (AUC: 0.81 [0.73–0.88] 95% CI; p < 0.001). Conclusions: PVC burden was an independent predictor of deterioration in LV-GLS. The presence of LV-GLS deterioration due to PVC burden emphasizes the necessity for closer patient monitoring, observation of the response to pharmacological treatment, and evaluation of early invasive treatment strategies in selected patient groups.
Evaluation of Joint Strength for CFRPs and Aluminum Alloys by Friction Stir Spot Welding Using Multi-Stage Heating
Authors: Tanaka Kazuto , Aiba Yusuke
Published: March 2024

To reduce car body weight, multi-material structures with lightweight materials such as carbon-fiber-reinforced plastics (CFRPs) and aluminum alloys (Als) are used to replace parts of steel components, and joining technologies for such dissimilar materials are essential. Friction stir spot welding (FSSW) is one of the technologies used to rapidly and strongly join dissimilar materials. FSSW for carbon-fiber-reinforced thermosetting resin (CFRTS) and Als has been developed using composite laminates with integrally molded thermoplastic resin in the outermost layer. To suppress excessive heating under the tool, this study investigated whether multi-stage heating with a non-heating time during joining affects the heat distribution and strength properties of the joint. Due to heat diffusion in Al during the non-heating time, multi-stage heating can suppress excessive heating under the tool compared to continuous heating, resulting in up to 27% larger welded area, up to 37% smaller decomposed area, and up to 6% lower maximum temperature. The use of multi-stage heating results in up to 5% higher tensile shear strength and 210% longer fatigue life by reducing the thermal decomposition of CFRP matrix resin and PA12 resin.
Fabrication and Characterization of Granulated β-Tricalcium Phosphate and Bioactive Glass Powders by Spray Drying
Authors: Nakanishi Akihiro , Ningsih Henni Setia , Putra Dwi Fortuna Anjusa , Moriga Toshihiro , Shih Shao-Ju
Published: March 2024

Biocomposite materials are widely implemented in various applications in clinical dentistry and orthopedics since it is possible to combine multiple materials by relying on their compatibility. Ceramic-based materials have osteogenic and osteoconductive features owing to their inorganic constituents with dental and bone tissue. β-tricalcium phosphate (β-TCP) and bioactive glass have excellent biocompatibility, bioresorbability, and bioactivity. In this study, β-TCP and BG powders were fabricated by spray pyrolysis (SP) and spray drying (SD). These fabrication methods are suitable for the mass production and synthesis of spherical particles. At first, β-TCP and BG spherical particles were synthesized by SP and characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and scanning electronic microscopy (SEM). After that, these powders were granulated with the different weight ratios of β-TCP/BG = 100/0, 75/25, 50/50, 25/75, and 0/100 by SD. The resulting granulation powders were characterized using XRD, FT-IR, and SEM to investigate phase compositions and microstructures. In addition, cytotoxicity was investigated using the MTT assay.
A Genetic Analysis of Current Medication Use in the UK Biobank
Authors: Rohde Palle Duun
Published: March 2024

Genomics has been forecasted to revolutionise human health by improving medical treatment through a better understanding of the molecular mechanisms of human diseases. Despite great successes of the last decade’s genome-wide association studies (GWAS), the results have been translated to genomic medicine to a limited extent. One route to get closer to improved medical treatment could be by understanding the genetics of medication use. Current medication profiles from 335,744 individuals from the UK Biobank were obtained, and a GWAS was conducted to identify common genetic variants associated with current medication use. In total, 59 independent loci were identified for medication use, and approximately 18% of the total variation was attributable to common genetic variation. The largest fraction of genetic variance for current medication use was captured by variants with low-to-medium minor allele frequency, with coding, conserved genomic regions and transcription start sites being enriched for associated variants. The average correlation (R) between medication use and the polygenic score was 0.14. The results further demonstrated that individuals with higher polygenic burden for medication use were, on average, sicker and had a higher risk for adverse drug reactions. These results provide an insight into the genetic contribution of medication use and pave the way for developments of novel multiple trait polygenic scores, which include the genetically informed medication use.
Influence of Pelvic Floor Disorders on Sleep Quality in Women
Authors: Peinado-Molina Rocío Adriana , Martínez-Vázquez Sergio , Hernández-Martínez Antonio , Martínez-Galiano Juan Miguel
Published: March 2024

Pelvic floor disorders, the impact of their symptoms, and their association with sleep quality and sleep disorders is a little studied area. The aim of this study was to determine if an association exists between pelvic floor disorders in women and sleep disorders. An observational study was conducted among women in Spain during 2021 and 2022. A self-developed questionnaire was used to collect sociodemographic and employment data, previous medical history and health status, lifestyle and habits, obstetric history, and health problems. A validated questionnaire, the Pittsburgh Sleep Quality Index (PSQI), was used to assess the quality of sleep. The presence and impact of pelvic floor problems was assessed with the Pelvic Floor Distress Inventory (PFDI-20). Odds ratios (OR) and adjusted odds ratios (aOR) with their respective 95% confidence intervals were calculated using logistic regression. A total of 1396 women participated in the study. The total PSQI indicated that 75.36% (1052) of women have altered general sleep quality. Women with pelvic floor disorders have a higher probability of developing sleep alterations (aOR: 1.32; 95% CI: 1.22–1.42; for every 20 points). A high BMI (aOR: 1.04; 95% CI: 1.01–1.07; for each point) and the presence of musculoskeletal disorders (aOR: 3.14; 95% CI: 1.20–8.27) are also associated with sleep quality in women. Women with pelvic floor disorders are more likely to develop sleep disorders, probably due to all the discomfort they entail.
Characterization of Plastic Scintillator Detector for In Vivo Dosimetry in Gynecologic Brachytherapy
Authors: Herreros Antonio , Pérez-Calatayud José , Ballester Facundo , Abellana Rosa , Neves Joana , Melo Joana , Moutinho Luis , Tarrats-Rosell Jordi , Serrano-Rueda Sergi , Tagliaferri Luca , Placidi Elisa , Rovirosa Angeles
Published: March 2024

(1) Background: High dose gradients and manual steps in brachytherapy treatment procedures can lead to dose errors which make the use of in vivo dosimetry (IVD) highly recommended for verifying brachytherapy treatments. A new procedure was presented to obtain a calibration factor which allows fast and robust calibration of plastic scintillation detector (PSD) probes for the geometry of a compact phantom using Monte Carlo simulations. Additionally, characterization of PSD energy, angular, and temperature dependences was performed. (2) Methods: PENELOPE/PenEasy code was used to obtain the calibration factor. To characterize the energy dependence of the PSD, the signal was measured at different radial and transversal distances. The sensitivity to the angular position was characterized in axial and azimuthal planes. (3) Results: The calibration factor obtained allows for an absorbed dose to water determination in full scatter conditions from ionization measured in a mini polymethylmethacrylate (PMMA) phantom. The energy dependence of the PSD along the radial distances obtained was (2.3 ± 2.1)% (k = 1). The azimuthal angular dependence measured was (2.6 ± 3.4)% (k = 1). The PSD response decreased by (0.19 ± 0.02)%/°C with increasing detector probe temperature. (4) Conclusions: The energy, angular, and temperature dependence of a PSD is compatible with IVD.
Exploring Costimulatory Blockade-Based Immunologic Strategies in Transplantation: Are They a Promising Immunomodulatory Approach for Organ and Vascularized Composite Allotransplantation?
Authors: Grosu-Bularda Andreea , Hodea Florin-Vlad , Zamfirescu Dragos , Stoian Alexandru , Teodoreanu Răzvan Nicolae , Lascăr Ioan , Hariga Cristian Sorin
Published: March 2024

The field of transplantation, including the specialized area of vascularized composite allotransplantation (VCA), has been transformed since the first hand transplant in 1998. The major challenge in VCA comes from the need for life-long immunosuppressive therapy due to its non-vital nature and a high rate of systemic complications. Ongoing research is focused on immunosuppressive therapeutic strategies to avoid toxicity and promote donor-specific tolerance. This includes studying the balance between tolerance and effector mechanisms in immune modulation, particularly the role of costimulatory signals in T lymphocyte activation. Costimulatory signals during T cell activation can have either stimulatory or inhibitory effects. Interfering with T cell activation through costimulation blockade strategies shows potential in avoiding rejection and prolonging the survival of transplanted organs. This review paper aims to summarize current data on the immunologic role of costimulatory blockade in the field of transplantation. It focuses on strategies that can be applied in vascularized composite allotransplantation, offering insights into novel methods for enhancing the success and safety of these procedures.
Characteristics Analysis and Prediction of Land Use Evolution in the Source Region of the Yangtze River and Yellow River Based on Improved FLUS Model
Authors: Gao Haoyue , Qin Tianling , Luan Qinghua , Feng Jianming , Zhang Xiuyan , Yang Yuhui , Xu Shu , Lu Jie
Published: March 2024

Climate change profoundly alters land use in alpine regions, and delving into the evolutionary characteristics of these changes is crucial for the sustainable development of regional land resources and the gradual enhancement of the ecological environment. Taking the source region of the Yangtze and Yellow River (SRYAYE) as a case study, we integrate permafrost and snowfall data into the Future Land Use Simulation model (FLUS). Analyzing historical land use, we predict and simulate the land use scenarios for 2030, 2035, and 2060 under SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5 climates, and conduct a detailed analysis of the scale, composition, and pattern of land use in this area. Scale. The results showed that ① the Kappa coefficient of the improved FLUS model was higher than 0.927, and that the overall accuracy of the simulation was increased by 2.64%; ② the area of forest land and the high-coverage grassland will increase in the future and the center of gravity will migrate to the west, and that the area of moderate and low-coverage grassland will slightly decrease but tend to become green to the west; and ③ the fragmentation degree of the SRYAYE is decreasing, and the influence of human activities on the landscape pattern is weaker than in the past.
Spatial Disparity and Residential Assessment of Housing Cost-Burdened Renters
Authors: Lee Hyunjeong
Published: March 2024

With the expanding rental sector and rising housing expenses, this research aims to compare the socio-demographic, economic, and housing statuses of renters burdened by housing costs in four regions, and also to explore predictors affecting their residential assessment. Using data from the 2020 Korean Housing Survey, this cross-sectional study identified 245 cost-burdened households whose housing expenses accounted for more than 25% of their total gross income and living expenses. The results revealed that the majority of renters were single-person households residing in single-room occupancy units of multifamily housing, primarily comprising unemployed older adults aged 50 and over. While earning less than half of the minimum wage, the renters’ living expenses fell well below the minimum cost of living, and more than 40% of the expenditure was spent on housing costs, resulting in cost-overburdened households. With the correlation between income, deposit, and rent, the burden of housing costs and the quality of the residential environment varied among regions. Indeed, the residential assessment of the renters was significantly influenced by urban amenities, and both income deficits and excessive housing cost burdens required inclusive and prompt housing interventions including housing assistance, provision of affordable public housing, income transfer, and transitions from renting to Chonsei arrangements.
Reflexive Morphology in the Kikongo Language Cluster: Variation and Diachrony
Authors: Dom Sebastian
Published: March 2024

This paper provides a comparative and diachronic account of reflexive morphology in the Kikongo language cluster, a genealogically closely related group of 40+ West Coastal Bantu languages. This study is based on data from 34 grammatical descriptions from 1659 to 2017 and fieldwork data collected in 2012 and 2015. Previous studies have shown that Kikongo languages, despite being closely related to each other, demonstrate extensive phonological and morphological variation. This is also the case for reflexive morphology. First, six different reflexive prefixes are attested in the database. These are, in alphabetical order, di- (with cognate li-), ké-, ki-, ku-, lu- and a vocalic morpheme variably written as i-, ii- or yi-. Second, while most Kikongo languages have one reflexive prefix, some descriptions report the use of two or more different prefix forms in a single language. Languages with multiple reflexive prefixes fall into two groups: one group has different prefixes in free alternation, while the overall verbal construction is claimed to determine which prefix is used in the other group. Following an overview of the formal variation, I discuss the possible origins of the various reflexive prefixes. One hypothesis assumes that the vocalic prefix is inherited from Proto-Kikongo, the most recent common ancestor of the Kikongo languages. A second hypothesis relates the origin of some reflexive prefixes to object indexes of various noun classes, in particular, noun classes 5, 7 and 11. A third hypothesis suggests that in some Kikongo languages, the vocalic reflexive prefix became fused with other pre-stem verbal morphology and developed into ku- and ki-. A fourth hypothesis proposes the development of the reflexive prefix ké- from an auxiliary. These four hypotheses are not mutually exclusive, and I discuss how multiple diachronic scenarios are necessary to account for the full range of variation of reflexive morphology in the Kikongo language cluster. It is proposed that the distribution of di-/li- and ki- is contact-induced through borrowing, both between different Kikongo languages and between Kikongo and non-Kikongo languages. I tentatively reconstruct the vocalic reflexive prefix *i- to Proto-Kikongo.
Treatment with Remdesivir of Children with SARS-CoV-2 Infection: Experience from a Clinical Hospital in Romania
Authors: Cocuz Maria-Elena , Cocuz Iuliu Gabriel , Rodina Ligia , Tataranu Elena , Caliman-Sturdza Olga Adriana , Filip Florin
Published: March 2024

Background: The COVID-19 pandemic was characterized by mild-to-moderate disease in children and adolescents, with low incidences of severe cases and mortality. Most of the information on drug therapy in COVID-19-positive children was derived from research in adult patients. Remdesivir, an inhibitor of viral RNA polymerase, was shown to be effective in COVID-19 patients with moderate-to-severe disease. In this study, we present our experience of the use of remdesivir in pediatric patients hospitalized with COVID-19. Materials and methods: This retrospective study was based on the early use of remdesivir in 14 children with mild, moderate, and severe clinical forms of COVID-19, who were hospitalized between 1 January 2022, and 30 September 2023. Results: The patients included eight infants and six children older than 1 day (the age range was 2 months to 17 years). Most of them (92.85%) had documented pneumonia. Four patients had associated acute laryngitis, and another had bronchiolitis. Coinfections with Streptococcus pneumoniae were diagnosed in two patients. The clinical course was favorable in 12/14 (85.71%) children. Two patients were transferred to the pediatric intensive care unit because of aggravation of associated acute diseases (acute laryngitis and bronchiolitis, respectively). Mild increases in alanine aminotransferase levels occurred in two patients, with no increase in serum creatinine, during treatment with remdesivir. Conclusion: The appropriate use of remdesivir proved safe and efficient in our group of patients. However, further studies are required to support the efficiency, tolerability, and safety of remdesivir in children.
Supplementation of Nicotinic Acid and Its Derivatives Up-Regulates Cellular NAD+ Level Rather than Nicotinamide Derivatives in Cultured Normal Human Epidermal Keratinocytes
Authors: Oyama Takahiro , Yamamoto Takumi , Kameda Takeshi , Kamiya Takanori , Abe Hideaki , Abe Takehiko , Tanuma Sei-ichi
Published: March 2024

Nicotinamide adenine dinucleotide (NAD+) plays a pivotal role in various physiological processes within mammalian cells, including energy metabolism, redox homeostasis, and genetic regulation. In the majority of mammalian cellular contexts, NAD+ biosynthesis primarily relies on vitamin B3, including nicotinamide (NAM) and nicotinic acid (NA). The concept of NAD+ augmentation therapy has recently emerged as a promising strategy to mitigate aging-associated phenomena, termed rejuvenation. Despite the involvement of diverse enzymatic cascades in NAD+ biosynthesis, certain cellular environments exhibit deficiencies in specific enzymes, suggesting cell type-dependent variability in optimal NAD+ precursor selection. However, the optimization of NAD+ precursors for topical formulations has received scant attention thus far. In the present investigation, we sought to delineate the most efficacious precursor for augmenting NAD+ levels in human skin keratinocytes. Remarkably, NA supplementation led to a significant 1.3-fold elevation in intracellular NAD+ levels, even in the presence of nicotinamide phosphoribosyltransferase inhibition by FK866. Additionally, NA mononucleotide demonstrated a 1.5-fold increase (but not significant) in NAD+ levels following 100 μM application. Conversely, NAM and its derivatives failed to elicit a NAD+ response in keratinocytes. Notably, NA supplementation elicited up-regulation of mitochondrial superoxide dismutase (SOD2) and sirtuin 3 (SIRT3), indicative of its beneficial impact on mitochondrial function. Furthermore, NA mitigated rotenone-induced mitochondrial reactive oxygen species (ROS) accumulation. Collectively, these findings advocate for the potential utility of NA in topical applications aimed at skin rejuvenation.
Designing an Intelligent Scoring System for Crediting Manufacturers and Importers of Goods in Industry 4.0
Authors: Ali Mohsin , Razaque Abdul , Yoo Joon , Kabievna Uskenbayeva Raissa , Moldagulova Aiman , Ryskhan Satybaldiyeva , Zhuldyz Kalpeyeva , Kassymova Aizhan
Published: March 2024

Background: The modern credit card system is critical, but it has not been fully examined to meet the unique financial needs of a constantly changing number of manufacturers and importers. Methods: An intelligent credit card system integrates the features of artificial intelligence and blockchain technology. The decentralized and unchangeable ledger of the Blockchain technology significantly reduces the risk of fraud while maintaining real-time transaction recording. On the other hand, the capabilities of AI-driven credit assessment algorithms enable more precise, effective, and customized credit choices that are specifically tailored to meet the unique financial profiles of manufacturers and importers. Results: Several metrics, including predictive credit risk, fraud detection, credit assessment accuracy, default rate comparison, loan approval rate comparison, and other important metrics affecting the credit card system, have been investigated to determine the effectiveness of modern credit card systems when using Blockchain technology and AI. Conclusion: The study of developing an intelligent scoring system for crediting manufacturers and importers of goods in Industry 4.0 can be enhanced by incorporating user adoption. The changing legislation and increasing security threats necessitate ongoing monitoring. Scalability difficulties can be handled by detailed planning that focuses on integration, data migration, and change management. The research may potentially increase operational efficiency in the manufacturing and importing industries.
Optimization Method of Sheet Metal Laser Cutting Process Parameters under Heat Influence
Authors: Wang Yeda , Liao Xiaoping , Lu Juan , Ma Junyan
Published: March 2024

To address the issues of workpiece distortion and excessive material melting caused by heat accumulation during laser cutting of thin-walled sheet metal components, this paper proposes a segmented optimization method for process parameters in sheet metal laser cutting considering thermal effects. The method focuses on predetermined perforation points and machining paths. Firstly, an innovative temperature prediction model Tpr,t is established for the nth perforation point during the cutting process, with a prediction error of less than 10%. Secondly, using the PSO-BP-constructed prediction model for laser cutting quality features and an empirical model for processing efficiency features, a multi-objective model for quality and efficiency is generated. The NSGA II algorithm is employed to solve the objective optimization model and obtain the Pareto front. Next, based on the predicted temperature at the perforation point using the model Tpr,t, the TOPSIS decision-making method is applied. Different weights for quality and efficiency are set during the cutting stages where the temperature is below the lower threshold and above the upper threshold. Various combinations of machining parameters are selected, and by switching the parameters during the cutting process, the thermal accumulation (i.e., temperature) during processing is controlled within a given range. Finally, the effectiveness of the proposed approach is verified through actual machining experiments.
Generalized Matrix Spectral Factorization with Symmetry and Construction of Quasi-Tight Framelets over Algebraic Number Fields
Authors: Lu Ran
Published: March 2024

The rational field Q is highly desired in many applications. Algorithms using the rational number field Q algebraic number fields use only integer arithmetics and are easy to implement. Therefore, studying and designing systems and expansions with coefficients in Q or algebraic number fields is particularly interesting. This paper discusses constructing quasi-tight framelets with symmetry over an algebraic field. Compared to tight framelets, quasi-tight framelets have very similar structures but much more flexibility in construction. Several recent papers have explored the structure of quasi-tight framelets. The construction of symmetric quasi-tight framelets directly applies the generalized spectral factorization of 2×2 matrices of Laurent polynomials with specific symmetry structures. We adequately formulate the latter problem and establish the necessary and sufficient conditions for such a factorization over a general subfield F of C, including algebraic number fields as particular cases. Our proofs of the main results are constructive and thus serve as a guideline for construction. We provide several examples to demonstrate our main results.
Federated Learning with Efficient Aggregation via Markov Decision Process in Edge Networks
Authors: Liu Tongfei , Wang Hui , Ma Maode
Published: March 2024

Federated Learning (FL), as an emerging paradigm in distributed machine learning, has received extensive research attention. However, few works consider the impact of device mobility on the learning efficiency of FL. In fact, it is detrimental to the training result if heterogeneous clients undergo migration or are in an offline state during the global aggregation process. To address this issue, the Optimal Global Aggregation strategy (OGAs) is proposed. The OGAs first models the interaction between clients and servers of the FL as a Markov Decision Process (MDP) model, which jointly considers device mobility and data heterogeneity to determine local participants that are conducive to global aggregation. To obtain the optimal client participation strategy, an improved σ-value iteration method is utilized to solve the MDP, ensuring that the number of participating clients is maintained within an optimal interval in each global round. Furthermore, the Principal Component Analysis (PCA) is used to reduce the dimensionality of the original features to deal with the complex state space in the MDP. The experimental results demonstrate that, compared with other existing aggregation strategies, the OGAs has the faster convergence speed and the higher training accuracy, which significantly improves the learning efficiency of the FL.