bluuebunny/crossref_metadata_2025 huggingface dataset:
Ionic Mobility and Phase Transitions in Perovskite Oxides for Energy Application
Authors: Cordero Francesco , Craciun Floriana , Trequattrini Francesco
Published: February 2017

Perovskite oxides ﬁnd applications or are studied in many ﬁelds related to energy production, accumulation and saving. The most obvious application is oxygen or proton conductors in fuel cells (SOFCs), but the (anti)ferroelectric compositions may ﬁnd application in high energy capacitors for energy storage, efﬁcient electrocaloric cooling, and electromechanical energy harvesting. In SOFCs, the diffusion of O vacancies and other mobile ionic species, such as H+, are at the base of the functioning of the device, while in the other cases they constitute unwanted defects that reduce the performance and life-time of the device. Similarly, the (anti)ferroelectric phase transitions are a requisite for the use of some types of devices, but the accompanying domain walls can generate extended defects detrimental to the life of the material, and structural phase transformations should be avoided in SOFCs. All these phenomena can be studied by mechanical spectroscopy, the measurement of the complex elastic compliance as a function of temperature and frequency, which is the mechanical analogue of the dielectric susceptibility, but probes the elastic response and elastic dipoles instead of the dielectric response and electric dipoles. The two techniques can be combined to provide a comprehensive picture of the material properties. Examples are shown of the study of structural transitions and hopping and tunnelling processes of O vacancies and H in the ion conductor BaCe1-xYxO3-x and in SrTiO3-x, and of the aging and fatigue effects found in PZT at compositions where the ferro- and antiferroelectric states coexist.
Ab Initio Study of the Elastic and Mechanical Properties of B19 TiAl
Authors: Wen Yufeng , Wang Long , Liu Huilong , Song Lin
Published: February 2017

A theoretical study of the structural, elastic, and mechanical properties of B19 TiAl intermetallic compound with orthorhombic structure has been carried out by using ab initio density functional theory calculations based on the projector augmented wave and the generalized gradient approximation. The optimized structure parameters are found to be in agreement with the available experimental data. The orthorhombic B19 structure of TiAl is found to be mechanically stable at ground state in terms of formation energy and single crystal elastic constants. Additionally, the polycrystalline bulk, shear and Young’s moduli, Poisson’s ratio, Cauchy pressure, and anisotropy factors are obtained from the single crystal elastic constants. At ground state, the B19 TiAl is found to not only have intrinsic brittleness in terms of Pugh’s ratio, Poisson’s ratio, and Cauchy pressure, but also exhibit elastic anisotropy in terms of elastic anisotropy factors and orientation dependence of Young’s modulus.
Potential Population Genetic Consequences of Habitat Fragmentation in Central European Forest Trees and Associated Understorey Species—An Introductory Survey
Authors: Dobeš Christoph , Konrad Heino , Geburek Thomas
Published: February 2017

Habitat fragmentation threatens the maintenance of genetic diversity of affected populations. Assessment of the risks associated with habitat fragmentation is a big challenge as the change in population genetic diversity is a dynamic process, often acting over long time periods and depending on various characteristics pertaining to both species (life history traits) and their populations (extrinsic characteristics). With this survey, we provide an introductory overview for persons who have to make or are interested in making predictions about the fate of forest-dwelling plant populations which have recently become fragmented and isolated from their main occurrences. We provide a concise introduction to the field of population genetics focusing on terms, processes and phenomena relevant to the maintenance of genetic diversity and vitality of plant populations. In particular the antagonistic effects of gene flow and random genetic drift are covered. A special chapter is devoted to Central European tree species (including the Carpathians) which we treat in detail with reference to an extensive literature survey on population genetic studies assembled from the whole of Europe. We further provide an overview of the population biology of associated understorey species. We conclude with recommended steps to be taken for the evaluation of potential perils of habitat fragmentation or population thinning for the genetics of tree populations. The complexity of effects exerted by life history traits and extrinsic characteristics of populations suggest population genetic development is strongly situation dependent. Therefore, we recommend following a case-by-case approach ideally supported by computer simulations to predict future population genetic development of both trees and associated understorey species.
Integration of Electric Vehicles into the Power Distribution Network with a Modified Capacity Allocation Mechanism
Authors: Hu Junjie , Morais Hugo , Sousa Tiago , You Shi , D’hulst Reinhilde
Published: February 2017

The growing penetration of electric vehicles (EVs) represents an operational challenge to system operators, mainly at the distribution level by introducing congestion and voltage drop problems. To solve these potential problems, a two-level coordination approach is proposed in this study. An aggregation entity, i.e., an EV virtual power plant (EV-VPP), is used to facilitate the interaction between the distribution system operator (DSO) and EV owners considering the decentralized electricity market structure. In level I, to prevent the line congestion and voltage drop problems, the EV-VPP internally respects the line and voltage constraints when making optimal charging schedules. In level II, to avoid power transformer congestion problems, this paper investigates three different coordination mechanisms, or power transformer capacity allocation mechanisms, between the DSO and the EV-VPPs, considering the case of EVs charging and discharging. The three mechanisms include: (1) a market-based approach; (2) a pro-rata approach; and (3) a newly-proposed constrained market-based approach. A case study considering a 37-bus distribution network and high penetration of electric vehicles is presented to demonstrate the effectiveness of the proposed coordination mechanism, comparing with the existing ones.
A Proportional Resonant Control Strategy for Efficiency Improvement in Extended Range Electric Vehicles
Authors: Wang Xiaoyuan , Lv Haiying , Sun Qiang , Mi Yanqing , Gao Peng
Published: February 2017

The key to control the range extender generation system is to improve the efficiency and reduce the emissions of the electric vehicle (EV). In this paper, based on the purpose of efficiency optimization, both engine and generator are matched to get a public high efficiency region, and a partial power following control strategy was presented. The engine speed is constant in the defined power range, so the output power regulation of the range extender is only realized by the adjustment of the torque of the generator. Engine speed and generator torque were decoupled. An improved proportional resonant (PR) controller is adopted to achieve fast output power regulation. In order to ensure the response characteristics of the control system and to improve the robustness, the impacts on system’s characteristics and stability caused by PR controller and parameters in the inner-current loop were analyzed via frequency response characteristics. A pre-Tustin with deviation compensation is proposed for PR controller’s discretization. A stable and robust power following control method is obtained for the range extender control system. Finally, simulation and experiment of the proposed control strategy illustrated its feasibility and correctness.
Peaking China’s CO2 Emissions: Trends to 2030 and Mitigation Potential
Authors: Liu Qiang , Gu Alun , Teng Fei , Song Ranping , Chen Yi
Published: February 2017

China has submitted its nationally determined contribution to peak its energy-related emissions around 2030. To understand how China might develop its economy while controlling CO2 emissions, this study surveys a number of recent modeling scenarios that project the country’s economic growth, energy mix, and associated emissions until 2050. Our analysis suggests that China’s CO2 emissions will continue to grow until 2040 or 2050 and will approximately double their 2010 level without additional policy intervention. The alternative scenario, however, suggests that peaking CO2 emissions around 2030 requires the emission growth rate to be reduced by 2% below the reference level. This step would result in a plateau in China’s emissions from 2020 to 2030. This paper also proposed a deep de-carbonization pathway for China that is consistent with China’s goal of peaking emissions by around 2030, which can best be achieved through a combination of improvements in energy and carbon intensities. Our analysis also indicated that the potential for energy intensity decline will be limited over time. Thus, the peaking will be largely dependent on the share of non-fossil fuel energy in primary energy consumption.
Geospatial Analysis of Photovoltaic Mini-Grid System Performance
Authors: Huld Thomas , Moner-Girona Magda , Kriston Akos
Published: February 2017

We present a geographic information system (GIS)-based tool for estimating the performance of photovoltaic (PV) mini-grid system over large geographical areas. The methodology consists of geospatial analysis and mapping of the energy output and reliability of PV mini-grid system. The algorithm uses a combination of hourly solar radiation data from satellites combined with measured data on PV module and battery performance and estimated electricity consumption data. The methods also make it possible to optimize the PV array and battery storage size for a given location. Results are presented for an area covering Africa and most of Southern and Central Asia. We also investigate the effects of using Li-ion batteries instead of the traditional lead-acid batteries. The use of our spatial analysis as decision support tool could help governments, local authorities and non-governmental organizations to investigate the suitability of PV mini-grids for electrification of regions where access to electricity is lacking. In this way it is possible to identify areas where PV mini-grids are most suitable.
Computational Study of the Noise Radiation in a Centrifugal Pump When Flow Rate Changes
Authors: Gao Ming , Dong Peixin , Lei Shenghui , Turan Ali
Published: February 2017

Noise radiation is of importance for the performance of centrifugal pumps. Aiming at exploring noise radiation patterns of a typical centrifugal pump at different flow rates, a three-dimensional unsteady hydro/aero acoustic model with large eddy simulation (LES) closure is developed. Specifically, the Ffowcs Williams-Hawkings model (FW-H) is employed to predict noise generation by the impeller and volute. The simulated flow fields reveal that the interactions of the blades with the volute induce root mean square (RMS) pressure and further lead to noise radiation. Moreover, it is found that the profiles of total sound pressure level (TSPL) regarding the directivity field for the impeller-generated noise demonstrate a typical dipole characteristic behavior, whereas strictly the volute-generated noise exhibits an apparently asymmetric behavior. Additionally, the design operation (Here, 1 Q represents the design operation) generates the lowest TSPL vis-a-vis the off-design operations for all the flow rates studied. In general, as the flow rates decrease from 1 Q to 0.25 Q, TSPL initially increases significantly before 0.75 Q and then levels off afterwards. A similar trend appears for cases having the larger flow rates (1–1.25 Q). The TSPL deviates with the radiation directivity and the maximum is about 50%. It is also found that TSPL by the volute and the blades can reach ~87 dB and ~70 dB at most, respectively. The study may offer a priori guidance for the experimental set up and the actual design layout.
Alkaline Earth Element Adsorption onto PAA-Coated Magnetic Nanoparticles
Authors: Wang Qing , Prigiobbe Valentina , Huh Chun , Bryant Steven
Published: February 2017

In this paper, we present a study on the adsorption of calcium (Ca2+) onto polyacrylic acid-functionalized iron-oxide magnetic nanoparticles (PAA-MNPs) to gain an insight into the adsorption behavior of alkaline earth elements at conditions typical of produced water from hydraulic fracturing. An aqueous co-precipitation method was employed to fabricate iron oxide magnetic nanoparticles, whose surface was first coated with amine and then by PAA. To evaluate the Ca2+ adsorption capacity by PAA-MNPs, the Ca2+ adsorption isotherm was measured in batch as a function of pH and sodium chlorite (electrolyte) concentration. A surface complexation model accounting for the coulombic forces in the diffuse double layer was developed to describe the competitive adsorption of protons (H+) and Ca2+ onto the anionic carboxyl ligands of the PAA-MNPs. Measurements show that Ca2+ adsorption is significant above pH 5 and decreases with the electrolyte concentration. Upon adsorption, the nanoparticle suspension destabilizes and creates large clusters, which favor an efficient magnetic separation of the PAA-MNPs, therefore, helping their recovery and recycle. The model agrees well with the experiments and predicts that the maximum adsorption capacity can be achieved within the pH range of the produced water, although that maximum declines with the electrolyte concentration.
Isolation and Characterization of Native Microalgae from the Peruvian Amazon with Potential for Biodiesel Production
Authors: Cobos Marianela , Paredes Jae , Maddox J. , Vargas-Arana Gabriel , Flores Leenin , Aguilar Carla , Marapara Jorge , Castro Juan
Published: February 2017

Biodiesel production from microalgae triacylglycerols is growing, because this feedstock is a more sustainable and advantageous alternative. In this study, we isolated and identified fourteen strains of native microalgae from the Peruvian Amazon. These strains showed great heterogeneity in biomass productivity, lipid productivity and lipid content, and thus, three of them (Acutodesmus obliquus, Ankistrodesmus sp. and Chlorella lewinii) were selected for further evaluation under culture of nitrogen-sufficient (+N) and nitrogen-deficient (−N) Chu medium No. 10. These microalgae species showed modifications in biomolecule content (protein, lipid and carbohydrate) with a pronounced increase of lipids and carbohydrate and a decrease of protein content under stress culture. Furthermore, the fatty acid profile was peculiar for each species, and these patterns showed evident changes, particularly in the proportion of saturated and monounsaturated fatty acids. The results of this research suggest that the isolated native microalgae, from the Peruvian Amazon, could be suitable candidates for biodiesel production
A Heuristic Diagnostic Method for a PV System: Triple-Layered Particle Swarm Optimization–Back-Propagation Neural Network
Authors: Liao Zhenghai , Wang Dazheng , Tang Liangliang , Ren Jinli , Liu Zhuming
Published: February 2017

This paper proposes a heuristic triple layered particle swarm optimization–back-propagation (PSO-BP) neural network method for improving the convergence and prediction accuracy of the fault diagnosis system of the photovoltaic (PV) array. The parameters, open-circuit voltage (Voc), short-circuit current (Isc), maximum power (Pm) and voltage at maximum power point (Vm) are extracted from the output curve of the PV array as identification parameters for the fault diagnosis system. This study compares performances of two methods, the back-propagation neural network method, which is widely used, and the heuristic method with MATLAB. In the training phase, the back-propagation method takes about 425 steps to convergence, while the heuristic method needs only 312 steps. In the fault diagnosis phase, the prediction accuracy of the heuristic method is 93.33%, while the back-propagation method scores 86.67%. It is concluded that the heuristic method can not only improve the convergence of the simulation but also significantly improve the prediction accuracy of the fault diagnosis system.
Recent Progress in the Microbial Production of Pyruvic Acid
Authors: Maleki Neda , Eiteman Mark
Published: February 2017

Pyruvic acid (pyruvate) is a cellular metabolite found at the biochemical junction of glycolysis and the tricarboxylic acid cycle. Pyruvate is used in food, cosmetics, pharmaceutical and agricultural applications. Microbial production of pyruvate from either yeast or bacteria relies on restricting the natural catabolism of pyruvate, while also limiting the accumulation of the numerous potential by-products. In this review we describe research to improve pyruvate formation which has targeted both strain development and process development. Strain development requires an understanding of carbohydrate metabolism and the many competing enzymes which use pyruvate as a substrate, and it often combines classical mutation/isolation approaches with modern metabolic engineering strategies. Process development requires an understanding of operational modes and their differing effects on microbial growth and product formation.
Non-Emergency Medical Transportation Needs of Middle-Aged and Older Adults: A Rural-Urban Comparison in Delaware, USA
Authors: Smith Matthew , Prohaska Thomas , MacLeod Kara , Ory Marcia , Eisenstein Amy , Ragland David , Irmiter Cheryl , Towne Samuel , Satariano William
Published: February 2017

Background: Older adults in rural areas have unique transportation barriers to accessing medical care, which include a lack of mass transit options and considerable distances to health-related services. This study contrasts non-emergency medical transportation (NEMT) service utilization patterns and associated costs for Medicaid middle-aged and older adults in rural versus urban areas. Methods: Data were analyzed from 39,194 NEMT users of LogistiCare-brokered services in Delaware residing in rural (68.3%) and urban (30.9%) areas. Multivariable logistic analyses compared trip characteristics by rurality designation. Results: Rural (37.2%) and urban (41.2%) participants used services more frequently for dialysis than for any other medical concern. Older age and personal accompaniment were more common and wheel chair use was less common for rural trips. The mean cost per trip was greater for rural users (difference of $2910 per trip), which was attributed to the greater distance per trip in rural areas. Conclusions: Among a sample who were eligible for subsidized NEMT and who utilized this service, rural trips tended to be longer and, therefore, higher in cost. Over 50% of trips were made for dialysis highlighting the need to address prevention and, potentially, health service improvements for rural dialysis patients.
Factors Influencing the Incidence of Obesity in Australia: A Generalized Ordered Probit Model
Authors: Avsar Gulay , Ham Roger , Tannous W.
Published: February 2017

The increasing health costs of and the risks factors associated with obesity are well documented. From this perspective, it is important that the propensity of individuals towards obesity is analyzed. This paper uses longitudinal data from the Household Income and Labour Dynamics in Australia (HILDA) Survey for 2005 to 2010 to model those variables which condition the probability of being obese. The model estimated is a random effects generalized ordered probit, which exploits two sources of heterogeneity; the individual heterogeneity of panel data models and heterogeneity across body mass index (BMI) categories. The latter is associated with non-parallel thresholds in the generalized ordered model, where the thresholds are functions of the conditioning variables, which comprise economic, social, and demographic and lifestyle variables. To control for potential predisposition to obesity, personality traits augment the empirical model. The results support the view that the probability of obesity is significantly determined by the conditioning variables. Particularly, personality is found to be important and these outcomes reinforce other work examining personality and obesity.
Is the Association between Park Proximity and Recreational Physical Activity among Mid-Older Aged Adults Moderated by Park Quality and Neighborhood Conditions?
Authors: Van Cauwenberg Jelle , Cerin Ester , Timperio Anna , Salmon Jo , Deforche Benedicte , Veitch Jenny
Published: February 2017

Previous studies have reported mixed findings on the relationship between park proximity and recreational physical activity (PA), which could be explained by park quality and the surrounding neighborhood environment. We examined whether park quality and perceptions of the neighborhood physical and social environment moderated associations between park proximity and recreational PA among mid-older aged adults. Cross-sectional self-reported data on park proximity, park quality, neighborhood physical and social environmental factors, recreational walking and other moderate- to vigorous-intensity recreational physical activity (MVPA) were collected among 2700 Australian adults (57–69 years) in 2012. Main effects between park proximity and measures of recreational PA were non-significant. Park proximity was positively related to engagement in recreational walking among participants who reported average and high social trust and cohesion, but not among those reporting low social trust and cohesion. No other moderating effects were observed. Current findings suggest synergistic relationships between park proximity and social trust and cohesion with mid-older aged adults’ recreational walking. More research is needed to unravel the complex relationship between parks, recreational PA and the social context of neighborhoods.
The Importance of Conditioned Stimuli in Cigarette and E-Cigarette Craving Reduction by E-Cigarettes
Authors: Van Heel Martijn , Van Gucht Dinska , Vanbrabant Koen , Baeyens Frank
Published: February 2017

This study examined the impact of four variables pertaining to the use of e-cigarettes (e-cigs) on cravings for tobacco cigarettes and for e-cigs after an overnight abstinence period. The four variables were the nicotine level, the sensorimotor component, the visual aspect, and the aroma of the e-cig. In an experimental study, 81 participants without prior vaping experience first got acquainted with using e-cigs in a one-week tryout period, after which they participated in a lab session assessing the effect of five minutes of vaping following an abstinence period of 12 h. A mixed-effects model clearly showed the importance of nicotine in craving reduction. However, also non-nicotine factors, in particular the sensorimotor component, were shown to contribute to craving reduction. Handling cues interacted with the level (presence/absence) of nicotine: it was only when the standard hand-to-mouth action cues were omitted that the craving reducing effects of nicotine were observed. Effects of aroma or visual cues were not observed, or weak and difficult to interpret, respectively.
Associations of Overweight, Obesity and Related Factors with Sleep-Related Breathing Disorders and Snoring in Adolescents: A Cross-Sectional Survey
Authors: Ma Yue , Peng Liping , Kou Changgui , Hua Shucheng , Yuan Haibo
Published: February 2017

Background: Sleep-related breathing disorders (SRBD) have been identified as a major public health problem closely related to adolescent obesity. We aimed to estimate the prevalences of SRBD and snoring in adolescents in Changchun City, Northeastern China, and to evaluate the associated factors in this population. Methods: In total, 1955 adolescents aged 11–18 years were recruited in Changchun City using stratified cluster sampling. Parents and caretakers of children completed the questionnaires, which included demographic characteristics, anthropometric parameters and a pediatric sleep questionnaire (SRBD scale). Logistic regression was used to analyze the relationship between SRBD, snoring and other factors. Results: The prevalences of SRBD and snoring in our population were 3.7% and 3.3%, respectively, and the prevalences of overweight and obesity were 12.6% and 4.9%. Multivariate logistic regression showed that urban residence (OR = 2.356, 95%CI: 1.251–4.435) and post-term birth (OR = 3.275, 95%CI: 1.396–7.683) were significantly associated with SRBD. Preterm birth (OR = 2.255, 95%CI: 1.021–4.980) and parental education level of university and above (OR = 0.265, 95%CI: 0.083–0.850) were significantly associated with snoring. Overweight (OR = 2.063, 95%CI: 1.062–4.006) was also related to snoring. Conclusions: The prevalences of SRBD and snoring were similar to those reported in previous studies. Urban residence and post-term birth were important influencing factors for SRBD; overweight, highest parental education level (university and above) and preterm birth were key factors affecting snoring in adolescents.
Discover Patterns and Mobility of Twitter Users—A Study of Four US College Cities
Authors: Li Yue , Li Qinghua , Shan Jie
Published: February 2017

Geo-tagged tweets provide useful implications for studies in human geography, urban science, location-based services, targeted advertising, and social network. This research aims to discover the patterns and mobility of Twitter users by analyzing the spatial and temporal dynamics in their tweets. Geo-tagged tweets are collected over a period of six months for four US Midwestern college cities: (1) West Lafayette, IN; (2) Bloomington, IN; (3) Ann Arbor, MI; (4) Columbus, OH. Various analytical and statistical methods are used to reveal the spatial and temporal patterns of tweets, and the tweeting behaviors of Twitter users. It is discovered that Twitter users are most active between 9:00 pm and 11:00 pm. In smaller cities, tweets aggregate at campuses and apartment complexes, while tweets in residential areas of bigger cities make up the majority of tweets. We also found that most Twitter users have two to four places of frequent visits. The mean mobility range of frequent Twitter users is linearly correlated to the size of the city, specifically, about 40% of the city radius. The research therefore confirms the feasibility and promising future for using geo-tagged microblogging services such as Twitter to understand human behavior patterns and carry out other geo-social related studies.
Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment
Authors: Vernot Jean-Paul , Bonilla Ximena , Rodriguez-Pardo Viviana , Vanegas Natalia-Del
Published: February 2017

An understanding of the cell interactions occurring in the leukemic microenvironment and their functional consequences for the different cell players has therapeutic relevance. By co-culturing mesenchymal stem cells (MSC) with the REH acute lymphocytic leukemia (ALL) cell line, we have established an in vitro leukemic niche for the functional evaluation of hematopoietic stem/progenitor cells (HSPC, CD34+ cells). We showed that the normal homeostatic control exerted by the MSC over the HSPC is considerably lost in this leukemic microenvironment: HSPC increased their proliferation rate and adhesion to MSC. The adhesion molecules CD54 and CD44 were consequently upregulated in HSPC from the leukemic niche. Consequently, with this adhesive phenotype, HSPC showed less Stromal derived factor-1 (SDF-1)-directed migration. Interestingly, multipotency was severely affected with an important reduction in the absolute count and the percentage of primitive progenitor colonies. It was possible to simulate most of these HSPC alterations by incubation of MSC with a REH-conditioned medium, suggesting that REH soluble factors and their effect on MSC are important for the observed changes. Of note, these HSPC alterations were reproduced when primary leukemic cells from an ALL type B (ALL-B) patient were used to set up the leukemic niche. These results suggest that a general response is induced in the leukemic niche to the detriment of HSPC function and in favor of leukemic cell support. This in vitro leukemic niche could be a valuable tool for the understanding of the molecular events responsible for HSPC functional failure and a useful scenario for therapeutic evaluation.
Phytochemical Analysis of Agrimonia pilosa Ledeb, Its Antioxidant Activity and Aldose Reductase Inhibitory Potential
Authors: Kim Set , Hwang Seung , Suh Hong-Won , Lim Soon
Published: February 2017

The aim of this study was to determine aldose reductase (AR) inhibitory activity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity of compounds from Agrimonia pilosa Ledeb (AP). We isolated agrimoniin (AM), four flavonoid glucosides and two flavonoid glucuronides from the n-butanol fraction of AP 50% methanol extract. In addition to isolated compounds, the AR-inhibitory activity and the DPPH free radical scavenging activity of catechin, 5-flavonoids, and 4-flavonoid glucosides (known components of AP) against rat lens AR (RLAR) and DPPH assay were measured. AM showed IC50 values of 1.6 and 13.0 μM against RLAR and DPPH scavenging activity, respectively. Additionally, AM, luteolin-7-O-glucuronide (LGN), quercitrin (QU), luteolin (LT) and afzelin (AZ) showed high inhibitory activity against AR and were first observed to decrease sorbitol accumulation in the rat lens under high-sorbitol conditions ex vivo with inhibitory values of 47.6%, 91.8%, 76.9%, 91.8% and 93.2%, respectively. Inhibition of recombinant human AR by AM, LGN and AZ exhibited a noncompetitive inhibition pattern. Based on our results, AP and its constituents may play partial roles in RLAR and oxidative radical inhibition. Our results suggest that AM, LGN, QU, LT and AZ may potentially be used as natural drugs for treating diabetic complications.
Developmental Origins of Chronic Kidney Disease: Should We Focus on Early Life?
Authors: Tain You-Lin , Hsu Chien-Ning
Published: February 2017

Chronic kidney disease (CKD) is becoming a global burden, despite recent advances in management. CKD can begin in early life by so-called “developmental programming” or “developmental origins of health and disease” (DOHaD). Early-life insults cause structural and functional changes in the developing kidney, which is called renal programming. Epidemiological and experimental evidence supports the proposition that early-life adverse events lead to renal programming and make subjects vulnerable to developing CKD and its comorbidities in later life. In addition to low nephron endowment, several mechanisms have been proposed for renal programming. The DOHaD concept opens a new window to offset the programming process in early life to prevent the development of adult kidney disease, namely reprogramming. Here, we review the key themes on the developmental origins of CKD. We have particularly focused on the following areas: evidence from human studies support fetal programming of kidney disease; insight from animal models of renal programming; hypothetical mechanisms of renal programming; alterations of renal transcriptome in response to early-life insults; and the application of reprogramming interventions to prevent the programming of kidney disease.
Vanillin Protects Dopaminergic Neurons against Inflammation-Mediated Cell Death by Inhibiting ERK1/2, P38 and the NF-κB Signaling Pathway
Authors: Yan Xuan , Liu Dian-Feng , Zhang Xiang-Yang , Liu Dong , Xu Shi-Yao , Chen Guang-Xin , Huang Bing-Xu , Ren Wen-Zhi , Wang Wei , Fu Shou-Peng , Liu Ju-Xiong
Published: February 2017

Neuroinflammation plays a very important role in the pathogenesis of Parkinson’s disease (PD). After activation, microglia produce pro-inflammatory mediators that damage surrounding neurons. Consequently, the inhibition of microglial activation might represent a new therapeutic approach of PD. Vanillin has been shown to protect dopaminergic neurons, but the mechanism is still unclear. Herein, we further study the underlying mechanisms in lipopolysaccharide (LPS)-induced PD models. In vivo, we firstly established rat models of PD by unilateral injection of LPS into substantia nigra (SN), and then examined the role of vanillin in motor dysfunction, microglial activation and degeneration of dopaminergic neurons. In vitro, murine microglial BV-2 cells were treated with vanillin prior to the incubation of LPS, and then the inflammatory responses and the related signaling pathways were analyzed. The in vivo results showed that vanillin markedly improved the motor dysfunction, suppressed degeneration of dopaminergic neurons and inhibited microglial over-activation induced by LPS intranigral injection. The in vitro studies demonstrated that vanillin reduces LPS-induced expression of inducible nitric oxide (iNOS), cyclooxygenase-2 (COX-2), IL-1β, and IL-6 through regulating ERK1/2, p38 and NF-κB signaling. Collectively, these data indicated that vanillin has a role in protecting dopaminergic neurons via inhibiting inflammatory activation.
Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-β1/Smads Signal Transduction Pathway in IgA Nephropathy
Authors: Zhang Lei , Han Changsong , Ye Fei , He Yan , Jin Yinji , Wang Tianzhen , Wu Yiqi , Jiang Yang , Zhang Fengmin , Jin Xiaoming
Published: February 2017

Glomerular fibrosis has been shown to be closely related to the progression and prognosis of IgA nephropathy (IgAN). However, mechanism underlying IgAN glomerular fibrosis remains unclear. Recently, our study showed that plasma gelsolin (pGSN) was decreased in the serum of an IgAN mouse model and that pGSN deposition was found in the glomeruli. Another cytokine, TGF-β1, which is closely related to glomerular fibrosis, was also found to be highly expressed in the glomeruli. In the present study, we report that pGSN induces glomerular fibrosis through the TGF-β1/Smads signal transduction pathway. This is supported by the following findings: human mesangial cells (HMCs) show remarkable morphological changes and proliferation in response to co-stimulation with pGSN and polymeric IgA1 (pIgA1) from IgAN patients compared to other controls. Moreover, ELISA assays showed that more TGF-β1 secretion was found in HMCs supernatants in the co-stimulation group. Further experiments showed increased TGF-β1, Smad3, p-Smad2/3, Smad4, and collagen 1 and decreased Smad7 expression in the co-stimulation group. Our present study implied that the synergistic effect of pGSN and pIgA induced glomerular fibrosis via the TGF-β1/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients.
Preparation of Nanocellulose Reinforced Chitosan Films, Cross-Linked by Adipic Acid
Authors: Falamarzpour Pouria , Behzad Tayebeh , Zamani Akram
Published: February 2017

Adipic acid, an abundant and nontoxic compound, was used to dissolve and cross-link chitosan. After the preparation of chitosan films through casting technique, the in situ amidation reaction was performed at 80–100 °C as verified by Fourier transform infrared (FT-IR). The reaction was accompanied by the release of water which was employed to investigate the reaction kinetics. Accordingly, the reaction rate followed the first-order model and Arrhenius equation, and the activation energy was calculated to be 18 kJ/mol. Furthermore, the mechanical properties of the chitosan films were comprehensively studied. First, optimal curing conditions (84 °C, 93 min) were introduced through a central composite design. In order to evaluate the effects of adipic acid, the mechanical properties of physically cross-linked (uncured), chemically cross-linked (cured), and uncross-linked (prepared by acetic acid) films were compared. The use of adipic acid improved the tensile strength of uncured and chemically cross-linked films more than 60% and 113%, respectively. Finally, the effect of cellulose nanofibrils (CNFs) on the mechanical performance of cured films, in the presence of glycerol as a plasticizer, was investigated. The plasticized chitosan films reinforced by 5 wt % CNFs showed superior properties as a promising material for the development of chitosan-based biomaterials.
Expression of Iron-Related Proteins Differentiate Non-Cancerous and Cancerous Breast Tumors
Authors: Pizzamiglio Sara , De Bortoli Maida , Taverna Elena , Signore Michele , Veneroni Silvia , Cho William , Orlandi Rosaria , Verderio Paolo , Bongarzone Italia
Published: February 2017

We have previously reported hepcidin and ferritin increases in the plasma of breast cancer patients, but not in patients with benign breast disease. We hypothesized that these differences in systemic iron homeostasis may reflect alterations in different iron-related proteins also play a key biochemical and regulatory role in breast cancer. Thus, here we explored the expression of a bundle of molecules involved in both iron homeostasis and tumorigenesis in tissue samples. Enzyme-linked immunosorbent assay (ELISA) or reverse-phase protein array (RPPA), were used to measure the expression of 20 proteins linked to iron processes in 24 non-cancerous, and 56 cancerous, breast tumors. We found that cancerous tissues had higher level of hepcidin than benign lesions (p = 0.012). The univariate analysis of RPPA data highlighted the following seven proteins differentially expressed between non-cancerous and cancerous breast tissue: signal transducer and transcriptional activator 5 (STAT5), signal transducer and activator of transcription 3 (STAT3), bone morphogenetic protein 6 (BMP6), cluster of differentiation 74 (CD74), transferrin receptor (TFRC), inhibin alpha (INHA), and STAT5_pY694. These findings were confirmed for STAT5, STAT3, BMP6, CD74 and INHA when adjusting for age. The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL). Our results showed an association between some iron-related proteins and the type of tumor tissue, which may provide insight in strategies for using iron chelators to treat breast cancer.
Telehealth: Increasing Access to High Quality Care by Expanding the Role of Technology in Correctional Medicine
Authors: Young Jeremy , Badowski Melissa
Published: February 2017

The United States (US) has a large correctional population. However, many incarcerated persons lack access to evidence-based, up-to-date medical care, particularly by subspecialty providers, due to limitations of geography, travel, cost and other resources. The use of telehealth technologies can remove these barriers, increasing access to high quality, multidisciplinary care. Studies have shown that, with telemedicine, timely triage and medical management can be provided across many disciplines, which may lead to improved clinical outcomes and significant cost savings.
Comparative Efficacies of Antimicrobial Catheter Lock Solutions for Fungal Biofilm Eradication in an in Vitro Model of Catheter-Related Fungemia
Authors: Rosenblatt Joel , Reitzel Ruth , Vargas-Cruz Nylev , Chaftari Anne-Marie , Hachem Ray , Raad Issam
Published: February 2017

Fungal catheter-related bloodstream infections (CRBSIs)—primarily due to Candida species—account for over 12% of all CRBSIs, and have been progressively increasing in prevalence. They present significant health and economic burdens, and high mortality rates. Antimicrobial catheter lock solutions are an important prophylactic option for preventing fungal CRBSIs. In this study, we compared the effectiveness of two FDA-approved catheter lock solutions (heparin and saline) and three experimental antimicrobial catheter lock solutions—30% citrate, taurolidine-citrate-heparin (TCH), and nitroglycerin-citrate-ethanol (NiCE)—in an in vitro model of catheters colonized by fungi. The fungi tested were five different strains of Candida clinical isolates from cancer patients who contracted CRBSIs. Time-to-biofilm-eradication was assessed in the model with 15, 30, and 60 min exposures to the lock solutions. Only the NiCE lock solution was able to fully eradicate all fungal biofilms within 60 min. Neither 30% citrate nor TCH was able to fully eradicate any of the Candida biofilms in this time frame. The NiCE lock solution was significantly superior to TCH in eradicating biofilms of five different Candida species (p = 0.002 for all).
Toward a Global Classification of Coastal Anthromes
Authors: Lazarus Eli
Published: February 2017

Given incontrovertible evidence that humans are the most powerful agents of environmental change on the planet, research has begun to acknowledge and integrate human presence and activity into updated descriptions of the world’s biomes as “anthromes”. Thus far, a classification system for anthromes is limited to the terrestrial biosphere. Here, I present a case for the consideration and validity of coastal anthromes. Every coastal environment on Earth is subject to direct and indirect human modification and disturbance. Despite the legacy, ubiquity, and pervasiveness of human interactions with coastal ecosystems, coastal anthromes still lack formal definition. Following the original argument and framework for terrestrial anthromes, I outline a set of coastal anthrome classifications that dovetail with terrestrial and marine counterparts. Recognising coastal environments as complex and increasingly vulnerable anthropogenic systems is a fundamental step toward understanding their modern dynamics—and, by extension, realising opportunities for and limits to their resilience.
Editorial: Friction and Lubricants Related to Human Bodies
Authors: Gebeshuber Ille , Van Aken George
Published: February 2017

Biolubrication plays a crucial role in assisting the sliding contacts in many organs in the human body.[...]
Experimental Study on Impact-Induced Reaction Characteristics of PTFE/Ti Composites Enhanced by W Particles
Authors: Li Yan , Wang Zaicheng , Jiang Chunlan , Niu Haohao
Published: February 2017

Metal/fluoropolymer composites are a category of energetic structural materials that release energy through exothermic chemical reactions initiated under highly dynamic loadings. In this paper, the chemical reaction mechanism of PTFE (polytetrafluoroethylene)/Ti/W composites is investigated through thermal analysis and composition analysis. These composites undergo exothermic reactions at 510 °C to 600 °C, mainly producing TiFx. The tungsten significantly reduces the reaction heat due to its inertness. In addition, the dynamic compression properties and impact-induced reaction behaviors of PTFE/Ti/W composites with different W content prepared by pressing and sintering are studied using Split Hopkinson Pressure Bar and high speed photography. The results show that both the mechanical strength and the reaction degree are significantly improved with the increasing strain rate. Moreover, as W content increases, the mechanical strength is enhanced, but the elasticity/plasticity is decreased. The PTFE/Ti/W composites tend to become more inert with the increasing W content, which is reflected by the reduced reaction degree and the increased reaction threshold for the impact ignition.
QM-HiFSA-Aided Structure Determination of Succinilenes A–D, New Triene Polyols from a Marine-Derived Streptomyces sp.
Authors: Bae Munhyung , Park So , Kwon Yun , Lee Sang , Shin Jongheon , Nam Joo-Won , Oh Dong-Chan
Published: February 2017

Based on profiles of secondary metabolites produced by marine bacteria obtained using LC/MS, succinilenes A–D (1–4), new triene polyols, were discovered from a culture of a Streptomyces strain SAK1, which was collected in the southern area of Jeju Island, Republic of Korea. The gross structures of 1–4 were primarily determined through analysis of NMR spectra. The double bond geometries of the succinilenes, which could not be established from conventional 1H NMR spectra because of the highly overlapped olefinic signals, were successfully deciphered using the recently developed quantum-mechanics-driven 1H iterative full spin analysis (QM-HiFSA). Succinilenes A–C (1–3) displayed inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production, indicating their anti-inflammatory significance. These three compounds (1–3) commonly bear a succinic acid moiety, although succinilene D (4), which did not inhibit NO production, does not have this moiety in its structure. The absolute configurations of succinilenes A–D (1–4) were established through J-based configuration analysis, the modified Mosher’s method following methanolysis, and CD spectral analysis.
The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH
Authors: Gabbia Daniela , Dall’Acqua Stefano , Di Gangi Iole , Bogialli Sara , Caputi Valentina , Albertoni Laura , Marsilio Ilaria , Paccagnella Nicola , Carrara Maria , Giron Maria , De Martin Sara
Published: February 2017

Edible seaweeds have been consumed by Asian coastal communities since ancient times. Fucus vesiculosus and Ascophyllum nodosum extracts have been traditionally used for the treatment of obesity and several gastrointestinal diseases. We evaluated the ability of extracts obtained from these algae to inhibit the digestive enzymes α-amylase and α-glucosidase in vitro, and control postprandial plasma glucose levels in a mouse model of non-alcoholic steatohepatitis (NASH); a liver disease often preceding the development of Type 2 diabetes (T2DM). This model was obtained by the administration of a high-fat diet. Our results demonstrate that these algae only delayed and reduced the peak of blood glucose (p < 0.05) in mice fed with normal diet, without changing the area under the blood glucose curve (AUC). In the model of NASH, the phytocomplex was able to reduce both the postprandial glycaemic peak, and the AUC. The administration of the extract in a diet particularly rich in fat is associated with a delay in carbohydrate digestion, but also with a decrease in its assimilation. In conclusion, our results indicate that this algal extract may be useful in the control of carbohydrate digestion and absorption. This effect may be therapeutically exploited to prevent the transition of NASH to T2DM.
Synthesis and Transport Properties of Novel MOF/PIM-1/MOF Sandwich Membranes for Gas Separation
Authors: Fuoco Alessio , Khdhayyer Muhanned , Attfield Martin , Esposito Elisa , Jansen Johannes , Budd Peter
Published: February 2017

Metal-organic frameworks (MOFs) were supported on polymer membrane substrates for the fabrication of composite polymer membranes based on unmodified and modified polymer of intrinsic microporosity (PIM-1). Layers of two different MOFs, zeolitic imidazolate framework-8 (ZIF-8) and Copper benzene tricarboxylate ((HKUST-1), were grown onto neat PIM-1, amide surface-modified PIM-1 and hexamethylenediamine (HMDA) -modified PIM-1. The surface-grown crystalline MOFs were characterized by a combination of several techniques, including powder X-ray diffraction, infrared spectroscopy and scanning electron microscopy to investigate the film morphology on the neat and modified PIM-1 membranes. The pure gas permeabilities of He, H2, O2, N2, CH4, CO2 were studied to understand the effect of the surface modification on the basic transport properties and evaluate the potential use of these membranes for industrially relevant gas separations. The pure gas transport was discussed in terms of permeability and selectivity, highlighting the effect of the MOF growth on the diffusion coefficients of the gas in the new composite polymer membranes. The results confirm that the growth of MOFs on polymer membranes can enhance the selectivity of the appropriately functionalized PIM-1, without a dramatic decrease of the permeability.