bluuebunny/crossref_metadata_2025 huggingface dataset:
“O VELHO E O DIABO”, OU: DO QUE FALAMOS QUANDO FALAMOS DE “HISTÓRIA E LITERATURA”?
Authors: Murari Luciana
Published: May 2019

Meu trabalho pode ser resumido em torno da pesquisa e análise da produção literária brasileira sob o ponto de vista historiográfico, pensando a literatura como um veículo privilegiado para a compreensão da situação histórica do país. Busco criar uma visão abrangente da produção escrita de nossa elite letrada, ou seja, daqueles que há décadas atrás ocupavam a posição que ocupamos hoje, nós, também uma elite letrada.
JEAN ROCHE NAS ENTRELINHAS DE JOSUÉ GUIMARÃES: A INFLUÊNCIA DE A COLONIZAÇÃO ALEMÃ E O RIO GRANDE DO SUL NA CONSTRUÇÃO DE A FERRO E FOGO
Authors: Ortiz Eduardo
Published: May 2019

O presente trabalho tem como objetivo investigar as relações entre história e literatura a partir dos romances históricos A ferro e fogo: tempo de solidão e A ferro e fogo: tempo de guerra, de Josué Guimarães, juntamente aos dois tomos da obra A colonização alemã e o Rio Grande do Sul, do historiador francês Jean Roche, analisando a forma como a narrativa do historiador serve de fonte de pesquisa para o romancista e o processo de ficcionalização da história.
Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells
Authors: Park Choa , Park Joonwoo , Shim Myeong Kuk , Rhyu Mee-Ra , Yoon Byung-Koo , Kim Kyung Sook , Lee YoungJoo
Published: May 2019

Atherosclerosis is the most common root cause of arterial disease, such as coronary artery disease and carotid artery disease. Hypoxia is associated with the formation of macrophages and increased inflammation and is known to be present in lesions of atherosclerotic. Vascular smooth muscle cells (VSMCs) are one of the major components of blood vessels, and hypoxic conditions affect VSMC inflammation, proliferation and migration, which contribute to vascular stenosis and play a major role in the atherosclerotic process. Estrogen receptor (ER)-β is thought to play an important role in preventing the inflammatory response in VSMCs. In this report, we studied the anti-inflammatory effect of indazole (In)-Cl, an ERβ-specific agonist, under conditions of hypoxia. Expression of cyclooxygenase-2 reduced by hypoxia was inhibited by In-Cl treatment in VSMCs, and this effect was antagonized by an anti-estrogen compound. Additionally, the production of reactive oxygen species induced under conditions of hypoxia was reduced by treatment with In-Cl. Increased cell migration and invasion by hypoxia were also dramatically decreased following treatment with In-Cl. The increase in cell proliferation following treatment with platelet-derived growth factor was attenuated by In-Cl in VSMCs. RNA sequencing analysis was performed to identify changes in inflammation-related genes following In-Cl treatment in the hypoxic state. Our results suggest that ERβ is a potential therapeutic target for the suppression of hypoxia-induced inﬂammation in VSMCs.
FERTILITY PRESERVATION: Construction and use of artificial ovaries
Authors: Dolmans Marie-Madeleine , Amorim Christiani A
Published: May 2019

Increasing numbers of patients are now surviving previously fatal malignant diseases, so for women of childbearing age, fertility concerns are paramount once they are cured. However, the treatments themselves, namely chemo- and radiotherapy, can cause considerable damage to endocrine and reproductive functions, often leaving these women unable to conceive. When such gonadotoxic therapy cannot be postponed due to the severity of the disease or for prepubertal girls, the only way to preserve fertility is cryobanking their ovarian tissue for future use. Unfortunately, with some types of cancer, there is a risk of reimplanting malignant cells together with the frozen-thawed tissue, so it is not recommended. A safer approach involves grafting isolated preantral follicles back to their native environment inside a specially created transplantable artificial ovary for their protection. This bioengineered ovary must mimic the natural organ and therefore requires an appropriate scaffold to encapsulate not only isolated follicles, but also autologous ovarian cells, which are needed for follicles to survive and develop. Here we review the indications for use of this artificial ovary and advances in the field that are bringing us ever closer to clinical implementation.
Physicians’ Attitudes on Resuscitation of Extremely Premature Infants: A Systematic Review
Authors: Cavolo Alice , Dierckx de Casterlé Bernadette , Naulaers Gunnar , Gastmans Chris
Published: May 2019

CONTEXT:

Whether to resuscitate extremely premature infants (EPIs) is a clinically and ethically difficult decision to make. Indications and practices vary greatly across different countries and institutions, which suggests that resuscitation decisions may be influenced more by the attitudes of the individual treating physicians. Hence, gaining in-depth insight into physicians’ attitudes improves our understanding of decision-making regarding resuscitation of EPIs.

OBJECTIVE:

To better understand physicians’ attitudes toward resuscitation of EPIs and factors that influence their attitudes through a systematic review of the empirical literature.

DATA SOURCES:

Medline, Embase, Web of Science, and Scopus.

STUDY SELECTION:

We selected English-language articles in which researchers report on empirical studies of physicians’ attitudes toward resuscitation of EPIs.

DATA EXTRACTION:

The articles were repeatedly read, themes were identified, and data were tabulated, compared, and analyzed descriptively.

RESULTS:

Thirty-four articles were included. In general, physicians were more willing to resuscitate, to accept parents’ resuscitation requests, and to refuse parents’ nonresuscitation requests as gestational age (GA) increased. However, attitudes vary greatly for infants at GA 23 to 24 weeks, known as the gray zone. Although GA is the primary factor that influences physicians’ attitudes, a complex interplay of patient- and non–patient-related factors also influences their attitudes.

LIMITATIONS:

Analysis of English-only articles may limit generalizability of the results. In addition, authors of only 1 study used a qualitative approach, which may have led to a biased reductionist approach to understanding physicians’ attitudes.

CONCLUSIONS:

Although correlations between GA and attitudes emerged, the results suggested a more complex interplay of factors influencing such attitudes.
RESEARCH OF THE PROPERTIES OF GRAPE PROCESSING PRODUCTS IN RELATION TO ITS APPLICATION IN SPA AND WELLNESS INDUSTRIES
Authors: Sarkisian G.
Published: May 2019

The work analyzes the global experience of using wines and grape-processing products to support a person’sphysical, mental, and psychological health, to slow down aging, to prevent and treat many diseases, in particular cardiovascular andoncological ones, endocrine system disorders, etc. It has been shown that a great deal of waste, including marc, is obtained whileprocessing grapes and producing wine. The fact has been pointed out that in Ukraine, the technologies of using wine-making waste infood and cosmetic industries and in medicine are being developed and introduced but slowly, though the level of viticulture is high.The importance and prospects of finding ways to process grape marc have been proved, as its valuable chemical composition allowsobtaining dietary supplements and oenotherapeutic products for spa and wellness industry. The following rational parameters havebeen suggested to extract the most valuable biologically active substances (polyphenols) from grape marc: microwave extraction;specific power of the microwave installation 1.6–1.7 kW/kg; 40% ethyl alcohol as the extractant; proportion of water(hydromodulus) 1:5; extraction temperature 60–65°C; 4 heating stages; stage interval 1.5–2 minutes; total extraction time 12–14minutes. The physico-chemical parameters of the marc extracts obtained from the grapes harvested in 2016 and 2017 have beendetermined. It has been established that, besides polyphenols, a whole complex of biologically active substances is extracted. It hasbeen shown that grape marc can be used to produce dietary fibre, pectins, and other valuable substances. The medical and biologicalproperties of the polyphenolic complex obtained from marc (the Odesky Chorny variety of grapes) have been studied on laboratoryrats to determine its antioxidant activity and the prospects of its use in treating type 2 diabetes. The protective properties of theobtained product have been proved. Such processes have been established to take place as the mobilization of the antioxidant systemof cells, the normalization of the enzyme activity of the antioxidant protection system, and a decrease in the level of markers ofoxidative modification of proteins and lipids (that are higher than normal with diabetes mellitus). It has been suggested to usepolyphenolic complex extracts in oenotherapy as a skin and face care product with protective properties.
PROSPECTS OF USING BY-PRODUCTS OF SUNFLOWER OIL PRODUCTION IN COMPOUND FEED INDUSTRY
Authors: Yegorov B. , Turpurova Т. , Sharabaeva E. , Bondar Y.
Published: May 2019

The article considers the possibility of obtaining a protein-rich feed additive from by-products of sunflower oil production. From literary sources it is known that in the global food market, Ukraine ranks first in cultivating the sunflower and in production and export of sunflower oil. Correspondingly, there are more by-products, such as press cakes and oil meal, which are high-protein feeds for farm animals. Recently, oil press factories have been producing high fat press cakes for farm animals and poultry’s energy needs. The shelf-life of high fat press cakes is very short, and besides, their physical properties are poor. So, it has been suggested to produce a protein-rich feed additive based on sunflower oil meal, sunflower press cake and limestone flour. The quality parameters of sunflower seeds and by-products of their processing have been determined. Five samples of the additive with different ratios of sunflower oil meal, sunflower press cakes, and limestone flour have been studied. The coefficient of variation characterizing the even distribution of the components in the additive has been determined. Besides the distribution of limestone flour in the additive, the distribution of sunflower press cake matter has been investigated, because it contains a lot of fat and has poor physical properties. The determination of the coefficients of variation by the distribution of limestone flour and by the distribution of sunflower press cake matter has shown that the mixing is the most effective when the recipe includes 75% of sunflower oil meal, 10 % of sunflower press cake, and 15% of limestone flour. A protein-rich feed additive based on by-products of the sunflower oil production has been developed. The additive can be used to feed animals and poultry.
USE OF DRIED CARROT POMACE IN THE TECHNOLOGY OF WHEAT BREAD FOR ELDERLY PEOPLE
Authors: Hryshchenko A. , Bilyk O. , Bondarenko Yu. , Kovbasa V. , Drobot V.
Published: May 2019

The paper considers the technological properties of dried carrot pomace obtained in the technology of organic direct pressing juices. Its use as a valuable source of food fibre and β-carotene in bread technology for elderly people has been substantiated. It has been established that dried carrot pomace has a larger particle size than flour, and its water absorption capacity is higher by 65%. A 5–15% dose of pomace makes the formation of dough longer by 1.5–6.5 min, significantly increases its viscosity and stability, as well as acidity. Due to the content of sugars available for yeast fermentation, the pomace contributes to the intensification of gas formation. The amount of wet gluten in pomace-containing dough decreases, as well as its water absorption capacity, and its resilience increases. This affects the structural and mechanical properties of dough, which has a decisive effect on the porous structure of finished products and their specific volume. A high quality of bread is achieved when the dose of dried carrot pomace is up to 5%, which helps to improve the colour and the taste. With an increasing dose, the specific volume and porosity of the products decrease. It has been proved that, due to the content of pectin and high hydrophilic properties, carrot pomace slows down the process of staling of bakery products. Calculations have shown that with the addition of 5% of the pomace, the content of β‑carotene in 100 g of bread increases by 15 times, and the fibre content by 3.4 times. With the consumption of 277 g of such bread, elderly people’s daily requirement of β-carotene is satisfied by 100.8%, and the that of dietary fibre by 4.1%.
EFFICIENCY OF USING THE ANIMAL PROTEIN COMPLEX IN THE TECHNOLOGY OF COOKED SAUSAGE
Authors: Peshuk L. , Gorbach O. , Galenko O. , Vovk L.
Published: May 2019

The research is dedicated to the development of recipes of cooked sausages and their diversification through including in the recipes poultry meat, and by-products of processing meat and milk. The meat products most affordable and popular with the Ukrainian people are selected for the study: cooked sausages and poultry meat wieners. The main components of the recipes are: red poultry meat, mechanically deboned poultry meat, medium-fat pork. In the recipes of the products developed, 10 % of the basic raw material was replaced with a hydrated protein-carbohydrate-mineral supplement. According to its physico-chemical characteristics, the protein-carbohydrate-mineral supplement in the technology of cooked sausage products allows us to get ready-made products with excellent quality parameters. It has been established that adding protein-carbohydrate-mineral supplement to the formulation significantly effects on the physico-chemical, functional, and technological parameters and biological value of meat products. The experimental data obtained show that the moisture content of the fresh stuffing for the sausages Kuryacha and the wieners Videnski is by 0.9 and 1.7%, respectively, higher than that in the control samples. The water-binding power in the fresh stuffing of the control samples is by 5% lower than in the test samples. In the finished product, the moisture-holding capacity is higher in the test samples (by 5.9% in the sausages Kuryacha, by 3.8% in the wieners Videnski). The study has shown that the amino acid score difference coefficient (AASDC) in the control sample of cooked sausage was by 11.2% higher than in the sample of the cooked sausage Kuryacha. In the control sausages, it was 13.0% higher than in the Videnski wieners. The developed cooked sausage products with the protein-carbohydrate-mineral supplement can be introduced into production as functional products with improved biological value.
Eastern Cape employers' views on the strengths and weaknesses of civil engineering diplomates entering the workplace
Authors: Gerber F , Mammen K
Published: May 2019

Employer perceptions in the Eastern Cape Province of South Africa have been reviewed to determine whether universities within the province produce civil engineering diplomates who meet industry's expectations. A questionnaire, which contained 30 questions (closed and open-ended), was designed to allow employers to assess the strengths and weaknesses of the students' academic training. These were distributed to a purposive sample of 546 employers using a web-based survey approach. Sixty-five percent of the targeted population who opened the invitations populated the questionnaire. The survey yielded an overall response rate of 28% (based on invitations sent). The data gathered was statistically analysed. The results indicate that employers deem the competencies of diplomates to be "neither high nor low", when employers are considered as a single, comprehensive cohort. Within employer representative subgroups statistically significant differences were, however, observed. Of the competencies assessed, "individual and teamwork ability" received the highest and "engineering design ability" the lowest rating. Overall, the results indicate that employers within the Eastern Cape Province are reasonably satisfied with the competencies of newly qualified diplomates, but point to the need for the strengthening of "engineering design ability", "professional and technical communication ability" and "problem-solving ability" competencies within the diploma programme curriculum.
The application of restructuring of knowledge in civil engineering
Authors: Verbeek T , Bothma T
Published: May 2019

In this paper, it is shown how knowledge theories and knowledge acquisition techniques are integrated by contextualisation to lead to the drawing of concept maps that can be used in civil engineering design, and to analyse and record specific experience. The concept maps form part of concept-based ontologies that are analysed to identify problems and constraints. Solutions to these problems and constraints create new knowledge and can be reported and linked to the world-wide-web. This linkage is made possible by utilising the Top-Level-Ontologies or Upper-Level-Ontologies to link to existing or new ontologies on the world-wide-web. The logic base acts as a procedure to lead and integrate all the above-mentioned aspects into three modules. These modules of the logic base are described and simple examples are given of how the logic base functions. The logic base is a technique to bring knowledge closer to the practising engineer, and facilitates thinking processes that will greatly assist in systematising knowledge, the analysis thereof and making it accessible on the word-wide-web.
Üretici, tüketici ve sürdürülebilirliği açısından üretici pazarı değerlendirmesi: Yalova köylü üretici pazarı
Authors: ARICI Fatih
Published: May 2019

Üretici pazarları, doğrudan pazarlama kanalları içerisinde en yaygın olanıdır. Yerel gıda üretimini teşvik etmenin yanı sıra çiftçiye ek gelir, tüketiciler için de taze ve uygun fiyata alışveriş imkânı sağlamaktadır. Ayrıca kırsal ekonomilerin canlanmasına ve aracıların aşılmasında da önemli katkıları bulunmaktadır. Çalışmada tüm dünyada hızla yaygınlaşan bu tedarik sistemi ele alınmıştır. Başta ABD ve AB ülkeleri olmak üzere son 20-30 yıl içerisinde üretici pazarlarında ciddi bir artış yaşanmaktadır. Üretici pazarları Türkiye’de 2012 yılında yasal zemine kavuşmuştur. Ancak, Türkiye için henüz gelişen bu tedarik sisteminin yasal düzenlemeden önce bazı illerimizde farklı adlarla var olduğu görülmektedir. Bu pazarlardan biri de “Yalova köylü üretici” pazarıdır. Yalova’da uzun süreden beri varlığını koruyan bu pazar; konum, pazar yeri, üretici ve tüketici açısından değerlendirilmiştir. Çalışmanın amacı geleneksel hale gelmiş olan bu pazarın güçlü-zayıf yönlerinin tespiti ve yeni kurulacak pazarlar için kuruluş yeri ile sürdürülebilirlik açısından öneriler geliştirmektir. Çalışmada, literatürde var olan yöntemler ışığında üretici pazarlarının devamı ve başarısı için belirlenen kriterlere göre pazarın değerlendirmesi yapılmıştır. Üretici görüşlerinin tespitinde ise nitel araştırmalarda veri toplamada yaygın olarak kullanılan görüşme (mülakat) tekniğine başvurulmuştur. Yapılan değerlendirmede pazar yerinin ulaşım, otopark ve nüfus kitlesi bakımından avantajlı bir konumda yer aldığı tespit edilmiştir. Pazar yerinin müşterilerin taleplerini karşılayacak imkânlara da sahip olduğu görülmüştür. Çalışmanın Türkiye’de üretici pazarları üzerine kısıtlı olan literatüre katkı sağlaması beklenmektedir. Ayrıca geliştirilen önerilerin de yeni kurulacak pazarlar için ön fikir vermesi umulmaktadır.
High frequency spinal and ozone paravertebral theraphy for low back pain v1
Authors: Milla Reinaldo , Alfonso Anguiano Vega Gerardo , Nieto-Pescador Guadalupe , Reyes-Romero Miguel
Published: May 2019

The treatment protocol for patients with chronic low back pain and radiculopathy consisted in the application of two complementary therapies: 1) Infiltration of paravertebral ozone to decompress the disc and reverse the levels of proinflammatory cytokines secreted by the affected disc cells and 2) Electronic Synaptic Activation (SEA) in the affected pelvic member, to regenerate the affected nerves. The lumbar paravertebral ozone therapy protocol consisted of 12 infiltrations applied as follows: placement of the patient in the prone position, palpation of the spinous process suggestive of the level L4-L5, localization and marking of the points 2 cm laterally of the lumbar spinous process, asepsis with Iodopovidona and infiltration with needle 23G x 60mm or 80 mm depending on the thickness of the adipose panniculus in a slow manner in each site 10 ml of the ozone-oxygen mixture, at a concentration of 27 mcg / ml. The Synaptic 4000 PRO system (The Synaptic Corporation., 3176 S. Peoria Ct. Ste 110 Aurora, CO, USA), device was used, which received on June 20, 1997 authorization from the FDA for the relief and treatment of intractable chronic pain and for the treatment of acute postoperative and post-traumatic pain. This high frequency system provides electronic and transcutaneous stimulation in the lumbar region and along the path of the sciatic nerve through a pulse generator with one or two conductors. The SEA system supplies 400 to 40,000 Hertz and direct current (up to 57 mAmp); each therapy is made up of a set of electronic signals that are constantly changing in relation to frequency, duration and intensity since it is considered that if the same impulses are applied, the nervous system becomes refractory to the stimulus. The SEA treatment protocol consisted of 12 therapies, one every third day, by placing electrodes on the cutaneous surface, one at the level of the lumbar spine and three along the affected pelvic member following the path of the sciatic nerve: posterior aspect back of the thigh, calf and sole; in the case of bilateral low back pain and radiculopathy, electrodes were applied to both limbs in the same way. Each of the 12 SEA therapies lasted 20 minutes.
U Mass - Insulin tolerance test v1
Authors: Kim Jason
Published: May 2019

Summary: Insulin tolerance test measures systemic clearance of glucose following an intraperitoneal bolus injection of a physiological dose of insulin. This experiment measures insulin sensitivity in awake mice assuming that there are no alterations in the animal’s counterregulatory response. Insulin sensitivity is altered in obese mice.
U Mass - Lactate dehydrogenase v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment involves a spectrophotometric measurement using Roche Cobas Clinical Chemistry Analyzer.
U Mass - Lipase v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment involves a spectrophotometric measurement using Roche Cobas Clinical Chemistry Analyzer. Lipase is a gastrointestinal enzyme that processes fat/lipid digestion.
U Mass - Lipid metabolism v1
Authors: Kim Jason
Published: May 2019

Summary: Lipid metabolism is estimated by measuring systemic clearance of [1-14C] palmitate following a bolus injection in awake mice. Lipid metabolism is altered in obese mice.
U Mass - Organ-specific glucose uptake v1
Authors: Kim Jason
Published: May 2019

Summary: Glucose uptake in individual organs can be measured using a bolus injection of 2-deoxy-D-[1-14C] glucose, a non-metabolizable glucose analog, and by determining labeled metabolite levels in select tissues. Insulin resistance is characterized by reduced glucose metabolism and develops in obese mice.
U Mass - Protein metabolism v1
Authors: Kim Jason
Published: May 2019

Summary: Hyperinsulinemic-euglycemic clamp is the gold-standard method to assess insulin sensitivity. The hyperinsulinemic-euglycemic clamp is widely used in clinics and laboratories to measure insulin action on glucose utilization in humans and animals for clinical and basic science research. Incorporation of radioactive-labeled glucose during hyperinsulinemic-euglycemic clamps makes it possible to measure glucose metabolism in individual organs in awake mice. Impaired insulin sensitivity (insulin resistance) is a major characteristic of obesity and an early requisite event in the development of type 2 diabetes.
U Mass - Surgery – carotid artery cannulation v1
Authors: Kim Jason
Published: May 2019

Summary: Chronic indwelling catheter is placed in the carotid artery for blood sampling during experiments. Surival surgery is performed in anesthetized mice, and mice recover from surgery after 4~5 days.
U Mass - Surgery – jugular vein cannulation v1
Authors: Kim Jason
Published: May 2019

Summary: Chronic indwelling catheter is placed in the jugular vein for intravenous infusion and injection of drug, hormones, and metabolites. Surival surgery is performed in anesthetized mice, and mice recover from surgery after 4~5 days.
U Mass -Lactate v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment involves a spectrophotometric measurement using Roche Cobas Clinical Chemistry Analyzer. Serum lactate levels are affected by alterations in glucose and protein metabolism.
U Mass - Cholesterol (Total) v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment involves a spectrophotometric measurement using Roche Cobas Clinical Chemistry Analyzer. Serum levels of total cholesterol reflect cholesterol metabolism and are associated with cardiovascular disease.
U Mass - Chronic/acute phloridzin treatment v1
Authors: Kim Jason
Published: May 2019

Summary: Phloridzin is a potent inhibitor of renal glucose reabsorption and may be used to lower serum glucose levels. Phloridzin may be administered chronically to induce glycosuria and lower hyperglycemia in diabetic mice. Phloridzin may be administered acutely to reduce serum glucose levels for experiments in diabetic mice.
U Mass - Creatinine v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment involves a spectrophotometric measurement using Roche Cobas Clinical Chemistry Analyzer. Serum levels of creatinine reflect systemic protein metabolism.
U Mass - Cytokines Panel I - multiplex v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment provides the quantification of multiple cytokines and chemokines using multiplexed-Luminex technology based on beads containing specific antibodies. Serum cytokine levels reflect chronic or acute inflammation, and circulating cytokines and chemokines are altered in obesity. Cytokines Panel I include IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, KC (IL-8 homologue), IL-9, IL-10 (interleukin-10), IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17A, TNFα (tumor necrosis factor alpha), IFNγ (interferon gamma), IP-10 (interferon gamma-induced protein 10; CXCL-10), Eotaxin (CCL-11), G-CSF (granulocyte colony stimulating factor), GM-CSF (granulocyte macrophage colony stimulating factor), LIF (leukemia inhibitory factor), LIX (LPS- induced CXC chemokine), MCP-1 (monocyte chemotactic protein-1; CCL-2), M-CSF (macrophage colony stimulating factor), MIG (monokine induced by gamma interferon; CXCL- 9), MIP-1α (macrophage inflammatory protein alpha; CCL-3), MIP-1 (macrophage inflammatory protein beta; CCL-4), and MIP-2/RANTES (macrophage inflammatory protein 2- alpha; CXCL-2). A service can be requested for all or any combination of listed cytokines/chemokines for customized multiplexed Luminex assay.
U Mass - Cytokines Panel II - multiplex v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment provides the quantification of multiple cytokines and chemokines using multiplexed-Luminex technology based on beads containing specific antibodies. Serum cytokine levels reflect chronic or acute inflammation, and circulating cytokines and chemokines are altered in obesity. Cytokines Panel II include IL-16 (interleukin-16), IL-17E/IL-25, IL-21, IL-22, IL-28B, EPO (erythropoietin), Exodus-2 (CCL-21), Fractalkine (CX3CL1), MCP-5 (monocyte chemotactic protein-5; CCL-12), MIP-3α (macrophage inflammatory protein 3-alpha; CCL-20), MIP-3β(macrophage inflammatory protein 3-beta; CCL-19), and TARC (thymus and activation- regulated; CCL-17). A service can be requested for all or any combination of listed cytokines/chemokines for customized multiplexed Luminex assay.
U Mass - Glucose v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment measures blood or plasma glucose concentration using Analox GM9 Glucose Analyzer or GM7 Micro-Stat Rapid Multi-assay Analyzer. The measurement is based on the rate of oxygen uptake in the reaction between sample glucose and glucose oxidase. Plasma glucose levels are elevated (i.e., hyperglycemia) in obesity, insulin resistance, and type 2 diabetes.
U Mass - Exercise model v1
Authors: Kim Jason
Published: May 2019

Summary: In-cage free running wheel is used to voluntarily induce exercise in awake mice. Exercise affects insulin sensitivity and glucose metabolism.
U Mass - Gamma-glutamyl Transferase v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment provides the quantification of multiple cytokines and chemokines using multiplexed-Luminex technology based on beads containing specific antibodies. Serum cytokine levels reflect chronic or acute inflammation, and circulating cytokines and chemokines are altered in obesity. Cytokines Panel I include IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, KC (IL-8 homologue), IL-9, IL-10 (interleukin-10), IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17A, TNFα (tumor necrosis factor alpha), IFNγ (interferon gamma), IP-10 (interferon gamma-induced protein 10; CXCL-10), Eotaxin (CCL-11), G-CSF (granulocyte colony stimulating factor), GM-CSF (granulocyte macrophage colony stimulating factor), LIF (leukemia inhibitory factor), LIX (LPSinduced CXC chemokine), MCP-1 (monocyte chemotactic protein-1; CCL-2), M-CSF (macrophage colony stimulating factor), MIG (monokine induced by gamma interferon; CXCL9), MIP-1α (macrophage inflammatory protein alpha; CCL-3), MIP-1β (macrophage inflammatory protein beta; CCL-4), and MIP-2/RANTES (macrophage inflammatory protein 2alpha; CXCL-2). A service can be requested for all or any combination of listed cytokines/chemokines for customized multiplexed Luminex assay.
U Mass - Glucose Tolerance Test v1
Authors: Kim Jason
Published: May 2019

Summary: Glucose tolerance test measures systemic clearance of glucose following an intraperitoneal bolus injection of 20% dextrose. This experiment measures insulin sensitivity in awake mice assuming that there are no alterations in the animal’s pancreatic -cell function and insulin secretion. Insulin sensitivity is altered in obese mice.
U Mass - Glucose Tolerance Test with insulin secretion v1
Authors: Kim Jason
Published: May 2019

Summary: Glucose tolerance test with insulin secretion measures systemic clearance of glucose and systemic appearance of insulin following an intraperitoneal bolus injection of 20% dextrose. This experiment measures insulin sensitivity and insulin secretion (pancreatic -cell function) in awake mice assuming that there are no alterations in systemic insulin clearance. Insulin sensitivity and pancreatic -cell function are altered in obese mice.
U Mass - Hemoglobin A1c v1
Authors: Kim Jason
Published: May 2019

Summary: This experiment provides the quantification of multiple cytokines and chemokines using multiplexed-Luminex technology based on beads containing specific antibodies. Serum cytokine levels reflect chronic or acute inflammation, and circulating cytokines and chemokines are altered in obesity. Cytokines Panel I include IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, KC (IL-8 homologue), IL-9, IL-10 (interleukin-10), IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17A, TNFα (tumor necrosis factor alpha), IFNγ (interferon gamma), IP-10 (interferon gamma-induced protein 10; CXCL-10), Eotaxin (CCL-11), G-CSF (granulocyte colony stimulating factor), GM-CSF (granulocyte macrophage colony stimulating factor), LIF (leukemia inhibitory factor), LIX (LPSinduced CXC chemokine), MCP-1 (monocyte chemotactic protein-1; CCL-2), M-CSF (macrophage colony stimulating factor), MIG (monokine induced by gamma interferon; CXCL9), MIP-1α (macrophage inflammatory protein alpha; CCL-3), MIP-1β (macrophage inflammatory protein beta; CCL-4), and MIP-2/RANTES (macrophage inflammatory protein 2alpha; CXCL-2). A service can be requested for all or any combination of listed cytokines/chemokines for customized multiplexed Luminex assay.
U Mass - Hepatic gluconeogenesis v1
Authors: Kim Jason
Published: May 2019

Summary: Hepatic gluconeogensis is estimated using pyruvate tolerance test that measures systemic elevation of glucose partly derived from pyruvate and hepatic gluconeogensis following an intraperitoneal bolus injection of pyruvate in awake mice. Hepatic gluconeogenesis is affected by obesity and regulates glucose homeostasis.
Design and Implementation of a Cost Effective Quartz Crystal Microbalance System for Monitoring Small Changes on any Surface
Authors: TÜRKDOĞAN Sunay
Published: May 2019

Quartz crystal microbalance systems are widely
used in different fields from biology to electronic. Those devices are very
sensitive to mass changes on the piezoelectric crystal surface in nano gram
scale and therefore can be used to detect even a single virus on surface of any
substance. Although they are very practical and versatile, they are sold with
very high prices and thus hindering the usage for someone with tight research
budget.  In this work, we try to find a
cost effective solution and bring this device into the price range on two to
three orders of magnitude lower than the commercial counterparts. For that
purpose, we develop a cost effective quartz crystal microbalance system using a
cost effective microcontroller and a typical oscillator circuit and the final
product can be used in different fields to detect the mass change on any
surface caused by different reactions or effects.
Dentist’s Behavior Regarding Children and Adolescents Maltreatment
Authors: Cota Ana Lídia Soares , Queiroz Andreza Maria Correia de , Remígio Mariana Maria Castro Jatobá , Reis Daniel Alves , Kabengele Daniela Do Carmo
Published: May 2019

Child abuse is a serious violation of the child’s basic rights and the precocious diagnosis of maltreatment cases and early intervention are important for the protection of the involved individuals. Most of the lesions involve the mouth, craniofacial regions, and neck. Therefore, dentists are in an exceptionally favorable position to recognize child abuse. Thus, the aim of the present study, through an integrative review, to guide dentists in the identification and report of children and adolescents’ maltreatment. A review of the literature was performed from secondary sources such as manuals, official documents and articles from scientific journals published in the electronic databases “Scientific Electronic Library Online (SciELO) and “Latin American and Caribbean System on Health Sciences Information “ (LILACS). Based on the critical analysis carried out, it is concluded that it is an ethical, legal and moral duty of these healthcare professionals to recognize signs and behaviors indicative of any kind of child neglect, violence (physical, sexual and / or psychological abuse). The suspected or confirmed cases must be reported to the competent organs, aiming at the interruption of violent episodes and ensuring the inclusion of minors in policies that promote their full and healthy development.Keywords: Dentists. Child Abuse. Domestic Violence.ResumoOs maus-tratos contra crianças e adolescentes representam uma grave violação dos seus direitos básicos, sendo importante o diagnóstico precoce dos casos de violência e a intervenção precoce para a proteção dos indivíduos envolvidos. Uma vez que a maioria das lesões decorrentes das agressões envolvem a boca, regiões craniofaciais e pescoço, os cirurgiões-dentistas apresentam uma posição estrategicamente favorável para reconhecer o maltrato infantil. Desta forma, o objetivo do presente trabalho é, por meio de uma revisão integrativa, orientar os cirurgiões-dentistas na identificação e denúncia de maus-tratos contra crianças e adolescentes. Foi realizada uma revisão da literatura a partir de fontes secundárias como manuais, documentos oficiais e artigos de periódicos científicos publicados nas bases de dados eletrônicas “Scientific Eletronic Library Online” (SciELO) e “Literatura Latino-Americana e do Caribe em Ciências da Saúde” (Lilacs). Com base na análise crítica realizada, observou-se que é dever ético, legal e moral desses profissionais de saúde o reconhecimento de sinais e comportamentos indicativos de qualquer tipo de violência infantil (negligência, abuso físico, sexual e/ou psicológico), seguido da denúncia dos casos suspeitos ou confirmados junto ao Conselho Tutelar, visando a interrupção de episódios violentos e a garantia da inclusão dos menores em políticas de promoção de seu desenvolvimento pleno e saudável.Palavras-chave: Odontólogos. Maus-Tratos Infantis. Violência Doméstica.
Aesthetic and Functional Rehabilitation in Pediatric Dentistry Patient: Case Report
Authors: Rodrigues Felipe Vilasboas , Damasceno Janaina Emanuela , Costa-Pinto Roberto Amarante , Simões Francisco Xavier Paranhos Coêlho
Published: May 2019

A cárie dentária na atualidade continua sendo um problema de saúde pública, apesar do grande avanço tecnológico e de novas técnicas para preveni-la. Esta, se caracteriza como uma doença multifatorial, infecciosa e dieta dependente. Além disso, se apresenta mais prevalente em crianças devido a maior ingestão de carboidratos e sacarose, além de falta de controle motor durante higienização. O tratamento é dividido em quatro fases: sistêmica, preparatória, reabilitadora e manutenção. Assim, este artigo tem como objetivo relatar o caso clínico de criança de 6 anos de idade acometida por cárie precoce, descrevendo o tratamento em fases, compreendendo a reabilitação com resina composta nas unidades acometidas pela cárie e mantenedor de espaço com intuito de substituir as unidades na qual foram perdidas. Ao final do tratamento proposto, a paciente demonstrou satisfeita com o resultado, o que foi possível devolver a qualidade de vida da mesma.Palavras-chave: Cárie Dentária. Mantenedor de Espaço em Ortodontia. Saúde Bucal. Cimentos de Ionômero de Vidro.AbstractCurrently, caries is still a major problem in public healthy, despite the great technological development and new prevention methods. The caries is a multifactorial, infectious, transmissible and diet dependent disease. It is more prevalent in kids because of their higher intake of carbohydrates and sucrose, and the lack of motor control during the toothbrushing. The treatment is divided into four stages: systemic, preparatory, rehabilitative and maintenance. Thus, this article aims to report a case about a six-year-old child affected by early childhood caries, describing the treatment phases, comprising rehabilitation with composite created in units and space maintainer to replace the missing units. At the end of the treatment, the patient showed satisfaction with the outcome, restoring the quality of her life.Keywords: Dental Caries. Space Maintenance, Orthodontic. Oral Health. Pediatric Dentistry. Glass Ionomer Cements.
Evaluación de la enseñanza en el aula de programa de ingeniería mecánica de la Universidad Libre
Authors: MAGO RAMOS MARÍA GABRIELA
Published: May 2019

Esta investigación trata de la evaluación de la enseñanza en el aula del programa de Ingeniería Mecánica de la Universidad Libre utilizando un modelo pedagógico transversal, donde haya articulación hacia la investigación formativa y aplicada con valor social, contribuyendo al desarrollo del país. La fundamentación que se utiliza en este ámbito, es la integración de los procesos académicos en todas las áreas del programa, desde las asignaturas de ciencias básicas hasta las electivas de profundización, donde los estudiantes trabajan en forma conjunta y contextualizan el proceso a través de proyectos interdisciplinarios con formatos de evaluación que aportan los docentes de los temas vistos en clase. La evaluación será cuantitativa y cualitativa a través de instrumentos aplicados en talleres teórico-prácticos mediante pruebas piloto, con lo cual se espera un mejor aprovechamiento por parte de los estudiantes fortaleciendo las competencias científicas, técnicas y humanísticas con un proceso de formación hacia una educación de calidad, que les permita ser competitivos y que tengan apertura hacia nuevos entornos industriales, mejorando su perfil profesional, con valor en el mercado laboral tanto nacional como internacional.
Marketing experiencial: aproximaciones teóricas sobre su evolución como concepto y referencia sobre su funcionalidad para generar diferenciación en los mercados tradicionales
Authors: NIETO ALMANZA CHRISTIAN CAMILO , PÉREZ BORDA ÓSCAR JAVIER
Published: May 2019

La disciplina del marketing ha evolucionado de tal manera que la concepción clásica de transaccionalidad rápidamente se convirtió en un fundamento obsoleto en términos de competitividad. Nutrida por medio de los cambios generacionales, nuevas tendencias y la concienciación respecto al consumismo, esta disciplina ha originado nuevos tipos y formas de la misma, hasta consolidar lo que hoy por hoy, se presenta como el futuro de las marcas denominado Marketing Experiencial. Dada su trascendentalidad e impacto sobre la competitividad y posicionamiento de marca se realizó una exhaustiva revisión bibliográfica que entraña de manera secuencial los diferentes componentes conceptuales y teóricos que dieron lugar al Marketing Experiencial en 1999 gracias a Bernd Schmitt quien lo presenta como una herramienta fundamental para alcanzar la diferenciación de marca en los mercados altamente competitivos en el contexto internacional.
Pengembangan Ketahanan Pangan Melalui Pemberdayaan Masyarakat di Kawasan Rawan Konflik Timika Papua
Authors: Syarief Rizal , Sumardjo . , Kriswantriyono Agit , Wulandari Yulia Puspadewi
Published: May 2019

Conflict handling in Papua so far is more often done with the repressive approach. The impact of conflict level is not decreasing, even international rejection is increasing. For that reason, a more humanistic approach is needed, including through empowerment. The purpose of this research is to study the community empowerment model in conflict-prone areas as an effort to realize the food security and the strategy of model replication in another area. The research method is done by action research, and SWOT analysis to formulate the strategy of model replication. The empowerment model conducted in several ways. First, gradually improve farming skills more productive-with the introduction of simple agricultural technology brings the change of community behavior from nomadic to the subsystem. Second, farming in order to provide for basic needs and also daily, weekly, monthly income as well as savings for families. Third, business development efforts by partnerships, with the government, companies, and religious institutions. The nodes of empowerment activities are conducted through the Agribusiness Training Center (ATC) that facilitates all empowerment activities. There are several things to consider in the replication model of empowerment: identification of program targets, needs assessment, institutional initiation, technology selection, assistance to the program, and partnerships with various stakeholders.
TEMPLATE INTERNEXT - PAPER
Authors: Editorial Equipe
Published: May 2019

Submitting your paperEverything written for INTERNEXT is done so using our easy-to-follow template. This makes writing your paper as simple as possible; as all of the formatting is already laid out and each section is clearly explained – all you have to do is fill it in.Please download the relevant template and begin your writing process.
Prejudices towards the Catalans: An experience in primary education
Authors: Navarro Oscar , Sanchez-Verdejo Francisco Javier , Fernandes Filomena , Lopez Eduardo
Published: May 2019

In recent years, the society of our country has maintained a tense political situation between the Spanish state and the autonomous community of Catalonia. The children have been exposed to this situation and the comments heard may have been able to cause the appearance of prejudices or the creation of a stereotype about the inhabitants of this region. The beliefs of children from two different contexts, a rural setting and an urban one, the capital of Spain, have been taken into account. From a sample of students from two different contexts, we have obtained results that indicate that girls from Primary Education show more positive prejudices towards Catalans than boys. In addition, if we consider gender, children who live in an urban environment do not show differences when it comes to showing negative prejudices.

Keywords: Prejudices, Catalans, primary education, urban, rural.
Racist prejudices in different contexts. Differences between rural and urban environments
Authors: Acero Juana Maria Anguita , Martinez Oscar Navarro , Olivares Angel Luis Gonzalez , Martino Monica di
Published: May 2019

The purpose of this research is to analyse the presence of racist prejudices in response to certain statements in two different contexts, namely, a rural environment and an urban environment. A questionnaire was prepared using nine statements in respect to real situations of preconceived ideas regarding certain minority groups of society. Specifically, these situations refer to gypsies, Blacks, immigrants, Moroccans, beggars, refugees from Latin America or handicapped persons. The questionnaire was given to university students, who were asked to assess the racist characteristics of each statement on a scale of 1â€“4. The results obtained show certain differences that are detected between the two contexts in respect to participantsâ€™ perception of prejudice. The conclusion is that the presence of racist prejudices is very similar in the two contexts in which the research was carried out, with a high correlation between studentsâ€™ answers.

Keywords: Prejudices, university students, urban, rural
Physics textbooks and its network structures
Authors: Kralikova Petra , Teleki Aba
Published: May 2019

We can observe self-organised networks all around us. These networks are, in general, scale-invariant networks described by the Barabasi-Albert model. The self-organised networks show certain universalities. These networks, in simplified models, have scale-invariant distribution (power law distribution) and the characteristic parameter Î± of the distribution has value between 2 and 5. Textbooks are an essential part of the learning process; therefore, we analysed the curriculum in secondary school textbooks of physics from the viewpoint of semantic network structures. We converted the textbook into a tripartite network, where the nodes represented sentences, terms and formulae. We found the same distribution as for self-organised networks. Cluster analysis was applied on the resulting network and we found individual modulesâ€”clusters. We obtained nine clusters, three of which were significantly larger. These clusters presented kinematics of point mass, dynamics of point mass and gravitational field with electric field.

Keywords: Physics textbook, scale-invariant distribution, semantic network.
Assessing and developing social entrepreneurship competencies in university subjects
Authors: Tojar-Hurtado Juan-Carlos , Estrada-Vidal Ligia-Isabel
Published: May 2019

Universities and other scientific and academic entities have become aware of the need to promote entrepreneurship in higher education. Social entrepreneurship and the values that it promotes are to a large extent consistent with the transversal competencies that must be taught at University. This paper presents a tool (two versions) that allows for the evaluation of social entrepreneurship competencies in university subjects. The tool permits the analysis of the degree to which these competencies are developed in a specific subject, both from the perspective of the students and educators. The two versions (students and faculty) have been validated by experts, and in the case of the student version, a statistical validation has been carried out (reliability and construct validity). The conclusions of this research highlight the relevance of working on social entrepreneurship competencies in university classrooms, as well as the way in which each educator proposes improvement strategies.

Keywords: Social entrepreneurship, competency, licker scales, reliability, factor analysis.