bluuebunny/crossref_metadata_2025 huggingface dataset:
Cyber Security on the Edge: Efficient Enabling of Machine Learning on IoT Devices
Authors: Kumari Swati , Tulshyan Vatsal , Tewari Hitesh
Published: January 2024

Due to rising cyber threats, IoT devices’ security vulnerabilities are expanding. However, these devices cannot run complicated security algorithms locally due to hardware restrictions. Data must be transferred to cloud nodes for processing, giving attackers an entry point. This research investigates distributed computing on the edge, using AI-enabled IoT devices and container orchestration tools to process data in real time at the network edge. The purpose is to identify and mitigate DDoS assaults while minimizing CPU usage to improve security. It compares typical IoT devices with and without AI-enabled chips, container orchestration, and and assesses their performance in running machine learning models with different cluster settings. The proposed architecture aims to empower IoT devices to process data locally, minimizing the reliance on cloud transmission and bolstering security in IoT environments. The results correlate with the update in the architecture. With the addition of AI-enabled IoT device and container orchestration, there is a difference of 60% between the new architecture and traditional architecture where only Raspberry Pi were being used.
Thermal Simulation and Analysis of Outdoor Energy Storage Battery Cabinet (200kWh)
Authors: Hsueh Kan-Lin , Sung Lung-Yu , Wu Tzu-Chang , Liu Chih-Peng , Teng Li-Tao , Huang Chien-Chung , Lu Cian-Tong
Published: January 2024

Heat dissipation from Li-ion batteries is a potential safety issue for large-scale energy storage applications. Maintaining low and uniform temperature distribution, and low energy consumption of the battery storage is very important. We studied the fluid dynamics and heat transfer phenomena of a single cell, 16-cell modules, battery packs, and cabinet through computer simulations and experimental measurements. The results show that the temperature distribution of single cell is relatively uniform when the cell is facing the air flow. In a module, very high air flow rate and large gap between the cells can reduce the cell temperature. A pack with a good thermally conductive case is very important to ensure good heat dissipation of the battery module. Due to limited space in the cabinet, additional air inlets and outlets can be opened outside of the cabinet to slightly lower the pack temperature. Installing fins outside the cabinet can also slightly reduce the temperature inside the cabinet. Liquid cooling medium, such as water, is much better than the air-cooling medium.
Baseline Computed Tomography or Positron Emission Tomography in Patients with Locally Advanced High-Risk Breast Cancer Facilitates Highly Customized Radiation Therapy in Anatomical Areas beyond the Scope of Surgery
Authors: Borowiec Tomasz , Matkowski Rafał , Cybulska-Stopa Bożena , Kuniej Tomasz , Kołodziejczyk Andrzej , Dupla Dorota , Maciejczyk Adam
Published: January 2024

The aim of the study was to compare the standard baseline imaging, with extended radiological staging. To assess our hypothesis, we performed a prospective, single-centre study which included 132 participants recruited between October 2015 and March 2020. Descriptive statistics, the Friedman and chi-squared tests were performed and p < 0.05 was considered significant. Patients were grouped into two cohorts, CT scan cohort (n=87) and PET-CT cohort (n=43). In the first group the originally determined disease stage changed in 36.8 % of cases, in second group in 51.2 %. The consistency between assessment of axillary lymph nodes by imaging (cN) and the postoperative pathology report (pN) was evaluated. In most cases, clinical and pathological evaluation of involved nodes was consistent, for CT scan the result was χ2(1) = 18.98; p < 0.001, for PET-CT the result was χ2(1) = 6.41; p = 0.03. Highly customized radiation therapy defined as dose boost within the involved lymph nodes, not covered by surgeon, was applied in nine patients.
Bromelain: Unveiling its Potential as a Natural Anti-Inflammatory Agent through Effective Binding to Apoptosis-associated Speck-like Containing CARD (ASC)
Authors: Ferrari Ivan Vito
Published: January 2024

This theoretical study presents a novel perspective on the potential anti-inflammatory properties of Bromelain, a natural agent extracted from pineapple stems. The investigation explores the binding capabilities of Bromelain to Apoptosis-associated speck-like containing CARD (ASC), a crucial adapter molecule known for its involvement in inflammatory processes and inflammasome formation. For the first time, these findings suggest that Bromelain exhibits a notable affinity for ASC, indicating its promising role as a natural anti-inflammatory agent. This study sheds light on the molecular interactions that may contribute to Bromelain's therapeutic potential in modulating inflammatory responses.
Effects of Dust Storm and Wildfire Events on Phytoplankton Growth and Carbon Sequestration in the Tasman Sea, Southeast Australia
Authors: Duc Hiep Nguyen , Leys John , Riley Matthew L , White Stephen , Azzi Merched , Trieu Toan , Salter David , Ji Fei , Nguyen Huynh , Chang Lisa T.-C. , Monk Khalia , Firth Justine , Fuchs David , Barthelemy Xavier
Published: January 2024

Dust storms and wildfires occur frequently in southeastern Australia. Their effects on ecology, environment and population exposure have been the focus of many studies recently. Dust storms do not emit ground-sequestered carbon but wildfires emit significant quantities of carbon into the atmosphere. However, both natural events promote phytoplankton growth in water bodies because carbon, and other trace elements such as iron, deposit on the surface water of oceans. Carbon dioxide is reabsorbed by phytoplankton via photosynthesis. The carbon balance cycle due to dust storms and wildfires are not well known. Recent studies on the carbon emission of the 2019-2020 summer wildfires in eastern Australia indicated that this megafire event emitted approximately 715 million tonnes of CO2 (195 Tg C) into the atmosphere from burned forest areas. The projected increase in the frequency of wildfires due to climate change alters what was a carbon neutral process of reabsorbing emitted carbon by the forests, and subsequently cannot be achieved. With the result of net loss of sequestered carbon to the atmosphere, subsequently further promotes a warming climate. This study focusses on the association of dust storms and wildfires in southeastern Australia with phytoplankton growth in the Tasman Sea due to the February 2019 dust storm event and the 2019-2020 Black Summer wildfires. Central Australia and western New South Wales were the sources of the dust storm emission (11 to 16 February 2019) and the Black Summer wildfires occured along the coast of New South Wales and Victoria (from early November 2019 to early Januaray 2020). The results show the similarities and differences in the deposition of particulate matter, phytoplankton growth and carbon reabsorption patterns in the Tasman Sea from these events. Using WRF-Chem model, during the 5 days dust storm event in February 2019, approximately ~1230 tons of total dust were predicted to be deposited in the Tasman Sea while ~132,000 tons of PM10 were deposited in the early stage of the wildfires from 1 to 8 November 2019.
Study on the Effects of Wettability and Pressure in Shale Matrix Nanopores Imbibition during Shut-in Process by Molecular Dynamics Simulations
Authors: Jiang Wen , Lv Weifeng , Jia Ninghong , Lu Xiaoqing , Wang Lu , Wang Kai , Mei Yuhao
Published: January 2024

Shut-in after fracturing is generally adopted for wells in shale oil reservoirs, and imbibition occurring in matrix nanopores has been proven as an effective way to improve recovery. In this research, the molecular dynamics (MD) simulation was used to investigate the effects of wettability and pressure on nanopores imbibition during shut-in for a typical shale reservoir Jimsar. The results indicate that the microscopic advancement mechanism of the imbibition front is the competitive adsorption between “interfacial water molecules” at the imbibition front and “adsorbed oil molecules” on the pore wall. The essence of spontaneous imbibition involves the adsorption and aggregation of water molecules onto the hydroxyl groups on the pore wall. The flow characteristics of shale oil suggest that the overall push of the injected water to the oil phase is the main reason for the displacement of adsorbed oil molecules. Thus, shale oil especially the heavy hydrocarbon component in the adsorbed layer tends to slip on the walls. However, the weak slip ability of heavy components on the wall surface is an important reason that restricts the displacement efficiency of shale oil during spontaneous imbibition. The effectiveness of spontaneous imbibition is strongly dependent on the hydrophilicity of the matrix pore's wall. The better hydrophilicity of the matrix pore's wall facilitates higher levels of adsorption and accumulation of water molecules on the pore wall and requires less time for “interfacial water molecules” to compete with adsorbed oil molecules. During the forced imbibition process, the pressure difference acts on both the bulk oil and the boundary adsorption oil, but mainly on the bulk oil, which leads to the occurrence of wetting hysteresis. Meanwhile, shale oil still existing in the pore always maintains a good stratified adsorption structure. Because of the wetting hysteresis phenomenon, as the pressure difference increases, the imbibition effect gradually increases, but the actual capillary pressure gradually decreases and there is a loss in the imbibition velocity relative to the theoretical value. Simultaneously, the decline in hydrophilicity further weakens the synergistic effect of pressure difference because of the more pronounced wetting hysteresis. Thus, selecting an appropriate well pressure enables cost savings and maximizes the utilization of the formation's natural power for EOR.
Influence of Silica Fume and Metakaolin on Mechanical and Durability Properties of Reactive Powder Concrete under Different Curing Methods
Authors: Omar Mustafa H. , Yaseen Seror A. , Jaafar Hassan Talal , Najm Hadee Mohammad , Sor Nadhim Hamah
Published: January 2024

Reactive powder concrete (RPC) is a modern form of cementitious material. Major components include cement with a very low water-to-binder (w/b) ratio, steel fibres, superplasticizers, and very fine additives used in place of coarse aggregate, and very little water. The primary goal of this study is to examine the impact of immersion in sulfuric acid on compressive strength and to evaluate the impact of curing procedures on the preparation of RPC with high characteristics. The experimental work includes 4 mixes, which are prepared using 30 mm hooked-end steel fibers with a ratio of 0.4 by volume, silica fume and metakaolin with a ratio of 25% of cement weight. Compressive and indirect tensile strengths, ultrasonic velocity, and bulk density tests were conducted on the RPC that was prepared to evaluate its qualities. The results showed that heat curing resulted in a greater increase in strength than water curing did, and that mechanical properties improved with increasing SF more than MK additions. Heat-cured RPC demonstrated greater resistance to sulfuric acid immersion tests on compressive strength compared to water-cured RPC.
Variability in the Initial Growth Trajectory of Captive Bred Snakes of the Genus Epicrates
Authors: Ling Liliana Kwong Kwai , Toral Fábio Luiz Buranelo , Lara Leonardo Boscoli , Matos Alline Grasiele Silveira , Lima Tiago De Oliveira , Ferreira Walter Motta
Published: January 2024

The goal of this study was to characterize the initial growth trajectory of Epicrates assisi, 1 Epicrates cenchria, and Epicrates crassus snakes raised in captivity. An exponential model with 2 parameters for birth weight (A) and growth rate (k) was fitted for each animal. There was a significant 3 difference A and k among the three species, the means (standard error) for A and k parameters were 4 31 (0.3) g and 0.0027 (0.00006) for E. assisi, 27.6 (0.6) g and 0.0046 (0.00013) for E. cenchria and 25.9 5 (1.4) g and 0.0033 (0.00027) for E. crassus. We showed a significative variability between species for 6 initial growth trajectory. In addition, we also demonstrated the existence of variability within species, 7 which can be used to change the growth trajectory of snakes, being a tool for selection and genetic 8 improvement.9
Query Reformulation Approach Using Domain Specific Ontology
Authors: Javed Akabra , Ashraf Humaira , Jhanjhi NZ
Published: January 2024

Query reformulation is a fundamental task in information retrieval systems aimed at improving the accuracy and relevance of search results. This abstract presents a query reformulation approach that utilizes a domain-specific ontology to enhance the effectiveness of query reformulation. The use of ontology enables a more precise understanding of the domain and its associated concepts, leading to more accurate query interpretation and reformulation. The proposed approach consists of two main steps: ontology-based query interpretation and ontology-guided query expansion. The proposed approach use Power thesaurus tool that perform sentiment analysis for suggestion of the synonyms of the query words to improve the accuracy of the retrieved results. The proposed methodology gives high accuracy as compared to the previous approaches that used Wordnet for the suggestions of synonyms. The proposed approach demonstrates the potential of utilizing ontologies in query reformulation, offering a more accurate and context-aware search experience in domain-specific information retrieval systems.
Production Optimization, Partial Characterization, and Gluten-Digesting Ability of the Acid Protease from Clavispora lusitaniae PC3
Authors: Djekrif Scheherazed Dakhmouche , El Hadef El Okki Amel Ait Kaki , Bennamoun Leila , Djekrif Abdelhak , Nouadri Tahar , Gillmann Louisa
Published: January 2024

: Protease-producing yeasts were isolated from potato wastes and screened for protease production on skim milk agar plates The best producer of protease isolate was identified as Clavispora lusitaniae. The strain showed better enzyme production using tomato pomace and bread waste mix as a solid fermentation substrate. The optimized conditions improved enzyme activity and showed a maximal production of 33450±503 IU/g compared with the initial activity of 11205,78 ±360 without medium optimization. A threefold increase in protease activity after medium optimization proved the reliability of using the PBD and CCD design. A 19.76-fold purified enzyme and a yield of 32.94% were obtained after purification. The protease showed maximum activity at pH 4 and 60 °C and was resistant to Tween 20, Tween 40, SDS, and β-mercaptoethanol, Ca2+, and Mg2+ stimulated it. The protease activity was strongly inhibited in the presence of urea, and EDTA. The results revealed Clavispora lusitaniae protease's ability to degrade wheat seeds and flour gluten by 98.7% and 97% respectively under pH 4 for 24 hours at 40 °C. According to this study, this enzyme could be a potential candidate for the food industry, particularly for treating wheat seed and flour to reduce the immunogenicity of gluten.
History, Development and Characteristics of CRISPR-Cas System
Authors: Nazir Taha , Mirza Hameed , Taha Nida
Published: January 2024

CRISPR/Cas9-based gene therapy has gotten a lot of interest during last decade. This treatment protocol tries to fix disease-causing traits by changing the DNA code in the exact spot on the chromosome. Therefore, we have tried to elaborate the most current information that shows how well CRISPR/Cas9-based gene therapy works. In vivo methods, like the ones described in the next two lines, are used to study cells in live creatures, like babies that are growing or animals that are already grown up. It has also been suggested to use ex-vivo methods to change somatic stem cells or progenitor cells in a culture outside of the body before putting them back into the patient. CRISPR/Cas is a good way to change specific genes in the DNA. Clustered Regularly Interspaced Short Palindromic Repeats is the full name for CRISPR. Biotechnologists can use them to fix DNA instead of the body's natural ways of doing so. This helps physicians in treatment diseases that run in families more successfully. Cas9 is an enzyme that, along with a guide RNA, is part of the CRISPR/Cas system. As this new technology grows quickly, it is replacing normal medical processes with treatments that are more cutting-edge and can change people's lives. CRISPR-Cas technology has changed biology by making it possible to change genes quickly. CRISPR molecular tools (Cas9 or Cas12a) have a lot of potential, but they are not very useful right now because they depend on the target cell's own DNA repair systems. With or without a template, the body's natural DNA repair processes can fix DNA breaks caused by Cas9 and Cas12a-based technologies. People use these methods a lot, but their effectiveness ranges from cell type to cell type. HDR-mediated DNA repair is a part of cell division, so tools that target it don't work on cells that don't divide, like neurons. CRISPR-associated transposase (CAST) has recently been studied, which suggests that it may offer new ways to change genes with CRISPR. The CRISPR activator of type V-K that is part of CAST has the same structure as the transposase. This is because CRISPR systems can put DNA in the right place without the help of the cell's own DNA repair systems. But a lot of work is being done right now to improve Cas9 and Cas12a so that DNA can be put into a target gene more precisely. Experts are still working hard to come up with better and more reliable ways to change genes, so even though there may be a problem, both methods have useful uses.
Exploring the potential impact of non-invasive modifications of the Gut Microbiome on Cancer Immunotherapy – a narrative review
Authors: David Adi , Lev-Ari Shaked
Published: January 2024

The following narrative review embarks on a comprehensive exploration of the pivotal role played by the gut microbiome within the Diet-Microbiota-Immunity (DMI) tripartite, aiming to enhance anti-cancer immunotherapy efficacy.

While revolutionizing cancer treatment, resistance to immunotherapy and immune-related adverse events (irAEs) remain challenges. The tumor microenvironment (TME), shaped by cancer cells, influences immunotherapy resistance. The gut microbiome, influenced by genetics, environment, diet, and interventions, emerges as a critical player in TME reshaping, thereby modulating immune responses and treatment outcomes. Dietary patterns like the Mediterranean diet, caloric restriction modifications, and specific nutritional components show promise in influencing the tumor microenvironment and gut microbiome for better treatment outcomes. Antibiotics, disrupting gut microbiota diversity, may compromise immunotherapy efficacy.

This review emphasizes the need for tailored nutritional strategies to manipulate microbial communities, enhance immune regulation, and improve immunotherapy accessibility while minimizing side effects. Ongoing studies investigate the impact of dietary interventions on cancer immunotherapy, pointing towards promising developments in personalized cancer care. This narrative review synthesizes existing knowledge and charts a course for future investigations, presenting a holistic perspective on the dynamic interplay between dietary interventions, the gut microbiome, and cancer immunotherapy within the DMI tripartite.
Establishment of a Poliovirus Containment Program and Containment Certification Process for Poliovirus-Essential Facilities, United States 2017-2022
Authors: Ottendorfer Christy , Shelby Bryan , Sanders Cecelia A , Llewellyn Anna , Myrick Christy , Brown Christye , Suppiah Suganthi , Gustin Kortney , Haynes Smith Lia
Published: January 2024

Upon declaration of poliovirus (PV) type 2 eradication in 2015, the World Health Organization (WHO) published PV containment requirements in the Global Action Plan III (GAPIII) for mitigating risks of a facility-associated release post-eradication. In 2018, the 71st World Health Assembly resolution urged Member States retaining PV to appoint a National Authority for Containment (NAC), reduce the number of PV facilities, and submit applications for containment certification. The United States (US) NAC was established in 2018 for containment oversight, and two paths to WHO GAPIII containment certification were developed. Facilities retaining PV were identified through national poliovirus containment surveys. US NAC conducted 27 site visits at 18 facilities (20 laboratories: A/BSL-2 (65%), A/BSL-3 (20%), and storage-only (15%)) to verify implementation of US NAC’s preliminary containment measures. NAC identified areas for improvement in seven categories: primary containment, decontamination, hand hygiene, security, emergency response, training, and immunization practices. Sixteen facility applications were endorsed to pursue poliovirus-essential facility (PEF) certification whereas four facilities opted to withdraw during the containment certification process. The US made noteworthy progress in PV containment to enhance biosafety and biosecurity practices at US PV facilities to safeguard the polio eradication effort.
Wind Flow and its Interaction with a Mobile Solar PV System Mounted on Trailer
Authors: E. Majd Alireza , S. Adebayo David , Tchuenbou-magaia Fideline , Willetts James , Nwosu Dave , Matthews Zackery , Ekere Nduka Nnamdi
Published: January 2024

Efficient implementation of clean energy technologies, including pioneering solutions like mobile solar PV systems mounted on trailers (MSPT), is pivotal for addressing energy challenges, especially in regions with constrained power grid access. This endeavour is vital for meeting escalating elec-tricity demands and aligning with the UN Sustainable Development Goal (SDG) aimed at ensuring dependable and sustainable energy provision in developing countries. This paper investigates the aerodynamic behaviour of a designed MSPT using numerical and experimental approaches. Spe-cifically, the study focuses on the effects of wind velocity and tilt angels on the drag and lift forces, as well as drag and lift coefficients on the panel used in the MSPT system. Additionally, the overall wind force acting on the entire MSPT (including 9 large solar PV panels) was examined, considering the combined effects of wind flow and the system's geometry. The simulations were conducted using ANSYS-Fluent software and experimental testing was performed utilizing scaled-down models to validate the accuracy of the simulation. The insights and the knowledge from this study can be utilized to optimize the design, installation, and operation of such systems, ultimately enhancing their performance, reliability, and paving ways for further improvements in mobile solar PV technology.
Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin
Authors: Garrido Camila Caro , Vandooren Marie , Robeyns Koen , Debecker Damien P. , Alconero Patricia Luis , Leyssens Tom
Published: January 2024

This study explores the cocrystallization between the drug praziquantel (PZQ) and the nutraceutical curcumin (CU). The investigation revealed two novel solid forms: a cocrystal solvate with ethyl acetate and a non-solvated cocrystal. This novel drug-nutraceutical cocrystal is identi-fied as “generally recognized as safe” (GRAS) praziquantel-curcumin-ethyl acetate (2:1:1) co-crystal solvate. This latter undergoes desolvation, leading to the formation of the praziquan-tel-curcumin (2:1) cocrystal. The cocrystal solvate has ethyl acetate molecules occupying the voids with minimal interactions within the crystal lattice. The application of heat treatment induces solvent removal and prompts the transition to the non-solvated cocrystal, as highlighted by VT-XRD. Thermal analyses demonstrate the stability of the cocrystal solvate up to approximately 100°C, beyond which it transforms into the non-solvated phase, which eventually melts at 130°C.
Vejprty: The Story of a Declining Border Micro-Region in Bohemia
Authors: Vaishar Antonín , Šťastná Milada , Nosková Helena
Published: January 2024

This paper maps the causes of the demographic, economic and social decline of a selected border micro-region during the last century. The decline occurred due to the location being remote, lacking natural resources and having an unsuitable industrial structure. Historical events associated with the post-war deportation of the German population and efforts to create a classless society also played a role in the decline. The results are an 87% population decrease, the demise of most companies, a very low level of human capital and unemployment reaching up to 5%. In order to comprehend the current state of the border micro-region and predict future development, it is necessary to understand the development that has occurred since approximately the middle of the nineteenth century. The European countryside is certainly not homogeneous, and different regions have shown unique mixes of positional, natural, economic and political factors. Some hope has been raised in relation to the transition to a post-productive economy, a transition that turns the remoteness of the region into an advantage. This is confirmed by the positive migration balances of the smallest municipalities in the last decade.
Processing and Marketing of Rattan Cane in Ibadan Metropolis
Authors: Biyi-Ayetoso Wuraola , Jimoh Saka
Published: January 2024

This research investigates the socio-economic impact of rattan cane processing on the livelihoods of practitioners in Ibadan Metropolis. It comprehensively assesses raw material availability, examines factors influencing demand and supply, and evaluates sales to determine the profitability of rattan processors. With the snowball and total enumeration sampling methods, the study engages with a diverse group of rattan processors. The study reveals a concerning 36% acknowledgement of a decline in the availability of canes attributed to deforestation and over-exploitation. Notably, it emphasizes that rattan product manufacturing in Ibadan Metropolis operates at a craft level, employing tools like saws, hammers, knives, gas cylinders, pinches, and tape rules, impacting production efficiency and product longevity. Additionally, the research underscores the absence of government support and credit facilities reported by all respondents. The Market Margin analysis highlights varying profitability levels across rattan products, with chairs exhibiting notably higher profitability (32.22%) than others. Individual profit margins for specific products, such as chairs (145.00%), underscore the significance of processing costs, production time, and market demand. The study offers strategic recommendations, advocating for district-level service centres for training, technology transfer, and support to enhance skills and technical efficiency. It calls for government intervention through incentives, facilities, tax breaks, and policies to fortify the rattan trade, improving production standards and unlocking export market potential. Furthermore, financial support, technical assistance, and mechanization should be employed to reduce production costs and time, ultimately elevating income generation in the rattan industry. This research contributes valuable insights to the discourse on sustainable livelihoods and economic viability within the rattan sector.
Impact of COVID-19 Lockdown on Glycemic Control and Lifestyle Changes in Greek Children with Type 1 Diabetes Mellitus
Authors: Charalampidi Paraskevi , Vasilakis Ioannis-Anargyros , Konstantaki Evanthia , Kanaka-Gantenbein Christina , Kalafati Maria
Published: January 2024

In 2019, due to the global pandemic of the new coronavirus (SARS-CoV-2), lockdown was imposed in Greece. Children with Type 1 Diabetes (T1D) during that period had to maintain a good level of glycemic control despite the subversive changes in their lives. The aim of this study was to assess the impact of lockdown on glycemic control and lifestyle changes of children with type 1 diabetes. The present cross-sectional study included 59 children with T1D who measured their glucose levels through glucose monitoring systems (Continuous Glucose Monitoring, CGM) and Flash Glucose Monitoring (FGM)). Their glycemic profile and demographic data were recorded in three different periods (before, during and after the lockdown). The changes in their daily routine were farther investigated through a short questionnaire which assesses changes in lifestyle-related behavior during COVID 19 pandemic. A significant improvement was noted in the glycemic control of children with T1D during the restrictive measures. Boys scored higher on scale of lifestyle behavior changes during the pandemic (-0.1 vs. -0.3, p=0.015). The results of this study highlight the need for continuous education and insistence on children's adherence with the treatment plan and the beneficial effects of using the new technology for easier monitoring.
Development of BVLOS and Night Flight Safety Criteria through VLOS and Night Flight Testing
Authors: Kim Gyou Beom , Jin Jung Hoi , Choi Hee Jeong , Cho In Je
Published: January 2024

This study is focused on the development of criteria for night and visual line of sight (VLOS) flights, especially in the context of beyond visual line of sight (BVLOS) drone applications. While BVLOS technology is advancing globally, regulatory restrictions and conservative legal regulations often prohibit these flights. The goal is to provide experimental guidelines for operational procedures in night and BVLOS flights. The study aims to establish empirical criteria for physical distances in night and VLOS flights, using a test team composed of a pilot, recorder, and observers. The observers are tasked with assessing the identification and recognition distances, which are crucial for safe drone operations. The criteria established are based on different variables such as aircraft size, altitude, and visual acuity. This research involves extensive flight tests at varying altitudes using different types of drones and observers with differing visual acuities (20/20, 20/13.3, and 20/10). The study also examines the effect of communication equipment limitations on recognition distance and the use of lighting devices to minimize abnormal conditions during nighttime flights. Overall, the study's findings aim to contribute to the safe and efficient planning of BVLOS and night drone flights, especially considering the ever-evolving technology and regulatory landscape in this field.
Combination of Review and Design of Experiments to Optimize Computational Simulations on Bioprinting Nozzles
Authors: Gómez-Blanco J. Carlos , Macías-García Antonio , Rodríguez Rego Jesús Manuel , Mendoza Cerezo Laura , Sanchez-Margallo Francisco M. , Marcos Romero Alfonso Carlos , Pagador J. Blas
Published: January 2024

3D bioprinting, like 3D printing, is a process that builds structures by depositing material layer by layer. In the specific case of bioprinting, these layers are composed of a biocompatible material together with living cells, allowing the creation of three-dimensional structures that recreate functional tissues and organs. Bioprinting cell-laden structures is complicated by the high rate of cell damage and stress that occurs during the process, caused by the high pressures and stresses to which they are subjected. To minimise damage during the process, it is important to study and optimise certain bioprinting conditions beforehand and to analyse how they affect the cells by means of computational simulations. In this review, both quantitative and qualitative data are collected to improve the nozzle geometry through computational simulation studies. Optimal ranges for nozzle diameter (0.2-1mm) and length (8-10mm; 300-900μm) have been defined, and recommendations for improving nozzle performance during bioprinting, such as the provision of an inner angle of 20-30°, an inner EDTA coating and a shear stress of less than 10kPa, have been gathered. Finally, based on the data collected, a design of experiments is proposed to obtain an optimal bioprinting configuration for a particular bioink.
A Comprehensive Review of Wolbachia-Mediated Mechanisms to Control Dengue Virus Transmission in Aedes aegypti through Innate Immune Pathways
Authors: Sarwar Muhammad Sajjad , Mushtaq Iqra , Munzoor Iqra
Published: January 2024

Dengue virus (DENV) is spread by Aedes aegypti and causes significant global health risks. Alternative techniques are urgently needed because the current control mech-anisms are insufficient to reduce the transmission of DENV. Introducing Wolbachia pipientis into Ae. aegypti inhibits DENV transmission, however, the underlying mechanisms are still poorly understood. Innate immune effector upregulation, the regulation of autophagy, and intracellular competition between Wolbachia and DENV for lipids are among the theories for the mechanism of inhibition. Further-more, mainly three immune pathways Toll, IMD and JAK/STAT are involved in the host for the suppression of the virus. These pathways are activated by Wolbachia and DENV in the host and are responsible for the upregulation and downregulation of many genes in mosquitoes, which ultimately reduces the titer of the DENV in the host. The functioning of these immune pathways depends upon the Wolbachia, host and virus interaction. Here, we summarize the current understanding of DENV recognition by the Ae. aegypti’s immune system, aiming to create a comprehensive picture of our knowledge. Additionally, we investigated how Wolbachia regulates ac-tivation of multiple genes associated with the Toll and IMD pathway, for the reduc-tion of arboviruses.
The Beneficial Relationship between Restrictive Diet and Autophagy in Preventing Cancer Cells
Authors: Udristioiu Aurelian , Cojocaru Manole , Martin Liviu , Buciu Gabriel , Giubelan Alexandru , Marius Stancu Marius , Papurica Maria Daniela , Gheorghe Ioan-Ovidiu , Nica-Badea Delia , Gorecki Gabriel Petre
Published: January 2024

Background A diet rich in red meat, and poor in fruits and vegetables, can hinder the body's ability to detoxify, therefore, an alternative vegetarian diet maintained over a certain period, determines the elimination of excess toxins and accumulated residues, helping the body to regenerate and recharge energy. Following this simple rule, there are a multitude of benefits for our health. Significance of the autophagy process An even better regeneration of the body takes place during the black fast, in which senescent cells, (dead cells that no longer exercise any function, but instead produce inflammation in the body), are eliminated by autophagy, and in their place, the cells are stimulated stem. Aging can be associated with various pathological conditions if autophagy is not promoted by a healthy lifestyle. In elderly people, cells can show DNA mutations and accumulations of protein aggregates that impair the body's physiological processes. Several studies have shown that the activation of autophagy slows down the ageing process. Conclusions Aging, and its associated conditions of illness, are due to genomic instability caused by DNA damage, telomere shortening and epigenome changes that modulate gene expression.
PointBLIP: Zero-Training Point Cloud Classification Network Based on BLIP-2 Model
Authors: Xiao Yunzhe , Dou Yong , Yang Shaowu
Published: January 2024

Leveraging the open-world understanding capacity of large-scale visual-language pre-trained models has become a hot-spot in point cloud classification. Recent approaches rely on transferable visual-language pre-trained models, classifying point clouds by projecting them into 2D images and evaluating consistency with textual prompts. These methods benefit from the robust open-world understanding capabilities of visual-language pre-trained models and require no additional training. However, they face several challenges summarized as prompt ambiguity, image domain gap, view weights confusion, and feature deviation. In response to these challenges, we propose PointBLIP, a zero-training point cloud classification network based on the recently introduced BLIP-2 visual-language model. PointBLIP is adept at processing similarities between multi-images and multi-prompts. We separately introduce a novel method for point cloud zero-shot and few-shot classification, which involves comparing multiple features to achieve effective classification. Simultaneously, we enhance the input data quality for both the image and text sides of PointBLIP. In point cloud zero-shot classification tasks, we outperform state-of-the-art methods on three benchmark datasets. For few-shot classification tasks, to the best of our knowledge, we present the first zero-training few-shot point cloud method, surpassing previous works under the same conditions and showcasing comparable performance to full-training methods.
Bycatch of Common Pollinators in Pheromone Baited Traps for Monitoring Corn Earworm (Lepidoptera: Noctuidae) in Missouri Industrial Hemp
Authors: Akotsen-Mensah Clement , Ativor Isaac Newton , Foba Caroline Ngochip , Valliyodan Babu
Published: January 2024

Several traps are recommended for monitoring corn earworm, Helicoverpa zea (Boddie), an important pest of field, vegetable and fruit crops in the U.S. These traps, which are meant to capture H. zea in many cases end up capturing other insects. Helicoverpa zea has recently been found feeding on different seeds and dual-type (seed and fiber) hemp, Cannabis sativa L. (Rosales: Cannabaceae) causing serious damage. Limited work has been done on developing integrated pest management (IPM) for H. zea industrial hemp in Missouri. We evaluated the attractiveness of different traps with the aim of developing a monitoring system for the adult male H. zea in industrial hemp fields in two Missouri locations In addition, we recorded other non-target insects in the traps to determine trap selectivity. Commercially available green, clear, tricolor bucket traps Heliothis Scentry and Scentry Delta 1X traps baited with H. zea sex pheromones were evaluated in 2021 and 2022. Tricolor traps captured significantly more adult male H. zea than the other traps in both years. Non-target insects, mainly Xylocopa virginica (L.) (Hymenoptera: Apidae), Bombus spp (Hymenoptera: Apidae), and Apis mellifera L. (Hymenoptera: Apidae) were also captured. The tricolor trap captured the most bees. The presence of non-target species highlights the risk of using tricolor traps as a monitoring tool. This data provides information for planning the monitoring of corn earworm in industrial hemp farms in Missouri.
Faktor-Faktor yang Memengaruhi Keputusan Adopsi Benih Padi Varietas Rojolele Srinuk oleh Petani Kecamatan Delanggu Kabupaten Klaten
Authors: Hapsari Dennys Tyas , Widiyanti Emi , Rusdiyana Eksa
Published: January 2024

Rojolele Srinuk rice is a new variety developed by the National Nuclear Energy Agency (BATAN) with improved characteristics compared to its progenitor, Rojolele. This study investigates the internal and external factors of farmers who adopt the Rojolele Srinuk rice seed variety and those who do not. This study employs quantitative methodology. This investigation was conducted in Delanggu Sub-district, Klaten Regency. All of the participants in this investigation were rice farmers from the Delanggu Sub-district. The number of 48 respondents was chosen purposefully or intentionally as the sample size. They utilized descriptive analysis and logistic regression for analysis. Results indicated that factors such as age, education, farming experience, the nature of innovation, communication channels, and the function of agricultural extension agents were significant in determining adoption. Education, the essence of creation, and the role of agricultural extension agents substantially influence adoption decisions.
Pengetahuan Lokal Petani dalam Budidaya Tanaman Sayur di Desa Beruk, Kecamatan Jatiyoso, Kabupaten Karanganyar
Authors: Utami Sonia Canda Mahdafika , Anantanyu Sapja , Suminah Suminah
Published: January 2024

Population growth triggers the need for national food to increase, including the need for vegetable crops as a complement to human nutrition. Efforts made by farmers to meet the population’s needs for vegetable crops and a source of income, often have not paid attention to environmental conditions. Beruk Village is one of the villages where the people cultivate vegetables crops on the slopes of the mountains which should be used as a conservation area. This condition certainly requires farmers to always learn and apply appropriate local techniques so as not to harm the surrounding environment. This research aimed to explore the learning process of farmers in obtaining and examining local knowledge in vegetable cultivation. This study used a qualitative approach method with the interactive model analysis techniques of Miles and Huberman. The results showed that local knowledge of local farmers comes from parents/hereditary, local village farmers, and farmers outside the village through oral, experience, trial and error, and observation. The local knowledge includes seeding (garlic, onion, carrot), land processing stages and its frequency, ‘kalenan’ (horizontal drains), ‘kali gondhang’ (vertical drains), ‘plipit’ (the arrangement stones on the edge of ‘larikan’), benefits of spacing, planting time and season, intercropping, benefits of grass in agricultural land, fertilization methods, weeding, thinning, manual irrigation, utilization of agricultural and livestock waste, as well as method, age, and yield of harvest. The local agricultural tools used are hoe, crowbar, ‘ganco’, garden fork, trowel, sickle, bucket, sack, ‘lanjaran’, and its binder from natural material.
Digital Literacy: a New Culture of Learning in the Era of Digitalization Through Cyber Pedagogy Strategies
Authors: Herwani Suci , Pasiningsih Pasiningsih
Published: January 2024

The Covid-19 pandemic that occurred in Indonesia requires organizers interested in the world of education to have the ability to be creative and innovative so that learning continues. One way is to use technology in learning, one of them online learning. Online learning is different from face-to-face learning then the right strategy is needed so that learning can be understood by learners. Learning that is based on and uses internet media is called digital literacy-based learning, one of which uses Cyber Pedagogy. This strategy are designing, implementing, and evaluating the interactions that occur in cyber learning. The purpose of this study is to describe digital literacy in learning in the era of digitalization through Cyber Pedagogy. The research method used is literature study using a qualitative descriptive approach. The results research showed that Cyber Pedagogy strategies can help learners to think critically about the material obtained from the platforms on technology devices.
Citas poéticas en la poesía de cancionero entre la Edad Media y el Humanismo: cuestiones redaccionales. Parte I
Authors: Zinato Andrea
Published: January 2024

El artículo sondea las citas poéticas dentro de los denominados “decires con citas”, uno de los géneros cultivados por los poetas de cancionero. Además de su importancia literaria, las citas constituyen la tradición indirecta de tales composiciones, aportación muy útil para determinar su historia textual. Se analizan aquí la tradición directa e indirecta de las citas de [ID0127] Querella de amor del Marqués de Santillana, uno de los “decires con citas” más famosos.
En torno a un autógrafo: editar a Santa Teresa de Jesús
Authors: Baldissera Andrea
Published: January 2024

Este artículo pretende afrontar algunas cuestiones pendientes de la filología teresiana, la cual –pese a los grandes resultados conseguidos– continúa sin contar con ediciones críticas que aspiren a reconstruir, según la perspectiva de la filología de autor, el proceso de copia, corrección y (a veces de) reescritura del Libro de la Vida acometido por la misma santa. Para ilustrar el método y sus posibles frutos, respecto a la autobiografía de la mística abulense, se debaten algunos ejemplos significativos extraídos de la obra, y se pasa revista de algunas esmeradas ediciones, analizando su postura ecdótica y proponiendo un nuevo punto de vista.
Anesthetic Considerations for a Patient with Prosthetic Valves, AF, and PPM Undergoing Surgery for Misplaced Dental Implant in Paranasal Sinuses: A Case Report
Authors:   Anesthesiologist, Tawam Hospital, United Arab Emirates, Anesthesiology, Idar 383430, Gujarat, India., Murthy Sanam Narayana , Modi Girishkumar ,   Anesthesiologist, Tawam Hospital, United Arab Emirates,  Anesthesiology, Idar 383430, Gujarat, India., Kumar Vijay ,   Specialist Anesthesiologist, Tawam Hospital, United Arab Emirates,Idar 383430, Gujarat, India., Munagala Nagaraju ,   Specialist Anesthesiologist, Tawam Hospital, United Arab Emirates,Idar 383430, Gujarat, India., Panchal Kishan ,   Private practice, Anesthesiology, Idar 383430, Gujarat, India.
Published: January 2024

Managing pts with DVR, PPM, AF and HTN is a challenge to anesthesiologist because of risk due to endocarditis, bleeding, thromboembolism, malfunction of pacemaker and MI. Displacement of dental implant in paranasal sinus is not very rare but it primarily occurs in patient with severe pneumatization of maxillary sinus/or defect of alveolar process. The present case report highlights the anaesthetic management of a patient with double valve replacement (DVR), atrial fibrillation (AF) and permanent pacemaker (PPM) for misplaced dental implant in the paranasal sinuses. Successful non-cardiac surgeries in patients who have heart disease depends on good preoperative assessment, intraoperative and post-operative management.
Removal of Bronchial Thrombus and Perioperative Anesthetic Management in a Cardiac Case: A Case Report
Authors:   Senior resident, Department of Anesthesiology, Institute of Medical Sciences, Banaras Hindu Universit, Varanasi 221005, Uttar Pradesh, India., Shukla Pragya , Anand Shekhar ,   Senior resident, Department of Anesthesiology, Institute of Medical Sciences, Banaras Hindu Universit, Varanasi 221005, Uttar Pradesh, India., Verma Nimisha ,   Associate Professor, Department of Anesthesiology, Institute of Medical Sciences, Banaras Hindu Universit, Varanasi 221005, Uttar Pradesh, India.
Published: January 2024

A 63-year-old male with a history of Rheumatic heart disease with post-balloon mitral valvuloplasty (BMV) presented with a carcinoid tumor of the right lower lobe, posted for lobectomy plus regional lymph node resection. Anesthetic challenges and management of this patient is well described here. A rare post-operative complication i.e, blood clots in the bronchus, resulting in hypoxia and desaturation was found during the extubation time. Handling such complications with a bronchoscope is also discussed in this case report.