bluuebunny/crossref_metadata_2025 huggingface dataset:
Multicenter study on the diagnostic performance of multiframe volumetric laser endomicroscopy targets for Barrett’s esophagus neoplasia with histopathology correlation
Authors: Struyvenberg M R , de Groof A J , Kahn A , Weusten B L A M , Fleischer D E , Ganguly E K , Konda V J A , Lightdale C J , Pleskow D K , Sethi A , Smith M S , Trindade A J , Wallace M B , Wolfsen H C , Tearney G J , Meijer S L , Leggett C L , Bergman J J G H M , Curvers W L
Published: July 2020

Volumetric laser endomicroscopy (VLE) has been shown to improve detection of early neoplasia in Barrett’s esophagus (BE). However, diagnostic performance using histopathology-correlated VLE regions of interest (ROIs) has not been adequately studied. We evaluated the diagnostic accuracy of VLE assessors for identification of early BE neoplasia in histopathology-correlated VLE ROIs. In total, 191 ROIs (120 nondysplastic and 71 neoplastic) from 50 BE patients were evaluated in a random order using a web-based module. All ROIs contained histopathology correlations enabled by VLE laser marking. Assessors were blinded to endoscopic BE images and histology. ROIs were first scored as nondysplastic or neoplastic. Level of confidence was assigned to the predicted diagnosis. Outcome measures were: (i) diagnostic performance of VLE assessors for identification of BE neoplasia in all VLE ROIs, defined as accuracy, sensitivity, and specificity; (ii) diagnostic performance of VLE assessors for only high level of confidence predictions; and (iii) interobserver agreement. Accuracy, sensitivity, and specificity for BE neoplasia identification were 79% (confidence interval [CI], 75–83), 75% (CI, 71–79), and 81% (CI, 76–86), respectively. When neoplasia was identified with a high level of confidence, accuracy, sensitivity, and specificity were 88%, 83%, and 90%, respectively. The overall strength of interobserver agreement was fair (k = 0.29). VLE assessors can identify BE neoplasia with reasonable diagnostic accuracy in histopathology-correlated VLE ROIs, and accuracy is enhanced when BE neoplasia is identified with high level of confidence. Future work should focus on renewed VLE image reviewing criteria and real-time automatic assessment of VLE scans.
Esophageal contractile segment impedance from high-resolution impedance manometry correlates with mean nocturnal baseline impedance and acid exposure time from 24-hour pH-impedance monitoring
Authors: Horton Anthony , Posner Shai , Sullivan Brian , Cornejo Jennifer , Davis Andrea , Fields Monika , McIntosh Thasha , Gellad Ziad , Shimpi Rahul , Gyawali C Prakash , Patel Amit
Published: July 2020

Esophageal baseline impedance (BI) acquired during esophageal contraction (contractile segment impedance [CSI]) is proposed to improve BI accuracy in gastroesophageal reflux disease (GERD). We evaluated associations between CSI and conventional and novel GERD metrics. We analyzed high-resolution impedance manometry (HRIM) and ambulatory pH-impedance studies from 51 patients (58.6 ± 1.5 years; 26% F) with GERD symptoms studied off antisecretory therapy. Patients with achalasia or absent contractility were excluded. CSI (averaged across 10 swallows) and BI-HRIM (from the resting landmark phase) were acquired from the distal impedance sensors (distal sensor and 5 cm above the lower esophageal sphincter). Acid exposure time (AET) and mean nocturnal baseline impedance (MNBI) were calculated. Associations between CSI, BI-HRIM, MNBI, and AET were evaluated using correlation (Pearson) and receiver operating characteristic (ROC) analysis. Presenting symptoms included heartburn (67%), regurgitation (12%), cough (12%), and chest pain (10%). CSI-distal and CSI-5 each correlated with BI-HRIM, AET, and distal MNBI. Associations with AET were numerically stronger for CSI-distal (r = −0.46) and BI-HRIM-distal (r = −0.44) than CSI-5 (r = −0.33), BI-HRIM-5 (r = −0.28), or distal MNBI (r < −0.36). When compared to AET <4%, patients with AET >6% had significantly lower CSI-distal and BI-HRIM-distal values but not CSI-5, BI-HRIM-5, or MNBI. ROC areas under the curve for AET >6% were numerically higher for CSI-distal (0.81) than BI-HRIM-distal (0.77), distal MNBI (0.68–0.75), CSI-5 (0.68), or BI-HRIM-5 (0.68). CSI from HRIM studies inversely correlates with pathologic AET and has potential to augment the evaluation of GERD.
Capturing Spatiotemporal Patterns in Presence-Absence Data to Inform Monitoring and Sampling Designs for the Threatened Dakota Skipper (Lepidoptera: Hesperiidae) in the Great Plains of the United States
Authors: Post van der Burg Max , Austin Jane E , Wiltermuth Mark T , Newton Wesley , MacDonald Garrett
Published: July 2020

Declines among species of insect pollinators, especially butterflies, has garnered attention from scientists and managers. Often these declines have spurred governments to declare some species as threatened or endangered. We used existing presence–absence data from surveys for the threatened Dakota skipper Hesperia dacotae (Skinner) to build statistical maps of species presence that could be used to inform future monitoring designs. We developed a hierarchical Bayesian modeling approach to estimate the spatial distribution and temporal trend in Dakota skipper probability of presence. Our model included a spatial random effect and fixed effects for the proportion of two grassland habitat types: those on well-drained soils and those on poorly drained soils; as well as the topographic slope. The results from this model were then used to assess sampling strategies with two different monitoring objectives: locating new Dakota skipper colonies or monitoring the proportion of historically (pre-2000) extant colonies. Our modeling results suggested that the distribution of Dakota skippers followed the distribution of remnant grasslands and that probabilities of presence tended to be higher in topographically diverse grasslands with well-drained soils. Our analysis also showed that the probability of presence declined throughout the northern Great Plains range. Our simulations of the different sampling designs suggested that new detections were expected when sampling where Dakota skippers likely occurred historically, but this may lead to a tradeoff with monitoring existing sites. Prior information about the extant sites may help to ameliorate this tradeoff.
Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging
Authors: Dweck Marc R , Maurovich-Horvat Pál , Leiner Tim , Cosyns Bernard , Fayad Zahi A , Gijsen Frank J H , Van der Heiden Kim , Kooi M Eline , Maehara Akiko , Muller James E , Newby David E , Narula Jagat , Pontone Gianluca , Regar Evelyn , Serruys Patrick W , van der Steen Antonius F W , Stone Peter H , Waltenberger Johannes L , Yuan Chun , Evans Paul C , Lutgens Esther , Wentzel Jolanda J , Bäck Magnus
Published: July 2020

Atherosclerotic plaques prone to rupture may cause acute myocardial infarction (MI) but can also heal without causing an event. Certain common histopathological features, including inflammation, a thin fibrous cap, positive remodelling, a large necrotic core, microcalcification, and plaque haemorrhage are commonly found in plaques causing an acute event. Recent advances in imaging techniques have made it possible to detect not only luminal stenosis and overall coronary atherosclerosis burden but also to identify such adverse plaque characteristics. However, the predictive value of identifying individual adverse atherosclerotic plaques for future events has remained poor. In this Position Paper, the relationship between vulnerable plaque imaging and MI is addressed, mainly for non-invasive assessments but also for invasive imaging of adverse plaques in patients undergoing invasive coronary angiography. Dynamic changes in atherosclerotic plaque development and composition may indicate that an adverse plaque phenotype should be considered at the patient level rather than for individual plaques. Imaging of adverse plaque burden throughout the coronary vascular tree, in combination with biomarkers and biomechanical parameters, therefore holds promise for identifying subjects at increased risk of MI and for guiding medical and invasive treatment.
New insights of tricuspid regurgitation: a large-scale prospective cohort study
Authors: Vieitez José María , Monteagudo Juan Manuel , Mahia Patricia , Perez Leopoldo , Lopez Teresa , Marco Irene , Perone Francesco , González Teresa , Sitges Marta , Bouzas Alberto , González Violeta , Li Pedro , Alonso David , Carrasco Fernando , Adeba Antonio , de la Heras José María , Fernandez-Golfin Covadonga , Zamorano José Luis
Published: July 2020

Aims

To evaluate the burden of tricuspid regurgitation (TR) in a large cohort, determine the right ventricle involvement of patients with TR and determine the characteristics of isolated TR.

Methods and results

Prospective study where consecutive patients undergoing an echocardiographic study in 10 centres were included. All studies with significant TR (at least moderate) were selected. We considered that patients with one of pulmonary systolic hypertension >50 mmHg, left ventricular ejection fraction <35%, New York Heart Association III–IV, or older than 85 years, had a high surgical risk. A total of 35 088 echocardiograms were performed. Significant TR was detected in 6% of studies. Moderate TR was found in 69.6%, severe in 25.5%, massive in 3.9%, and torrential in 1.0% of patients. Right ventricle was dilated in 81.7% of patients with massive/torrential TR, in 55.9% with severe TR, and in 29.3% with moderate TR (P < 0.001). Primary TR was present in 7.4% of patients whereas secondary TR was present in 92.6%. Mitral or aortic valve disease was the most common aetiology (54.6%), following by isolated TR (16%). Up to 51.9% of patients with severe, massive, or torrential primary TR and 57% of patients with severe, massive, or torrential secondary TR had a high surgical risk.

Conclusion

Significant TR is a prevalent condition and a high proportion of these patients have an indication for valve intervention. More than a half of patients with severe, massive, or torrential TR had a high surgical risk. Massive/torrential TR may have implications regarding selection and monitoring patients for percutaneous treatment.
Long-term results of large-calibre expanded polytetrafluoroethylene-valved conduits with bulging sinuses
Authors: Fujita Shuhei , Yamagishi Masaaki , Miyazaki Takako , Maeda Yoshinobu , Itatani Keiichi , Yamamoto Yusuke , Asada Satoshi , Hongu Hisayuki , Nakatsuji Hiroki , Yaku Hitoshi
Published: July 2020

OBJECTIVES

In Japan, homograft and bovine jugular vein are available in very limited institutions for the reconstruction of the right ventricular outflow tract, and handmade expanded polytetrafluoroethylene (ePTFE)-valved conduits have been widely used instead. This study aimed to clarify the long-term outcomes and the durability of the ePTFE-valved conduits purely by narrowing down to those with large sizes to eliminate the influence of the body growth.

METHODS

Between January 2002 and December 2015, patients who underwent right ventricular outflow tract reconstruction in 34 Japanese institutions using ePTFE-valved conduits with a diameter of ≥18 mm were included. All the valved conduits were made in the authors’ institution and delivered to each participating institution.

RESULTS

Overall, 502 patients were included. Early mortality was 1.4% and not related to conduit failure. The overall survival rate was 98.2% at 5 years and 96.6% at 10 years. Freedom from conduit explantation was 99.5% at 5 years and 89.0% at 10 years. Three patients (0.13 per 100 patient-years) developed infective endocarditis of the conduit, and only 1 patient required conduit removal. Pulmonary insufficiency was mild or less in 480 (96%) patients, and conduit stenosis was mild or less in 436 (88%) patients at the latest follow-up.

CONCLUSIONS

By narrowing the analyses down to only ePTFE conduits with a large size, satisfactory long-term outcomes of these conduits with a fan-shaped valve and bulging sinuses were shown. These conduits would be among the optimal choices for right ventricular outflow tract reconstruction.
Impact of structural and process quality indicators on the outcomes of acute aortic dissection
Authors: Yamaguchi Tetsuo , Nakai Michikazu , Sumita Yoko , Miyamoto Yoshihiro , Matsuda Hitoshi , Inoue Yousuke , Yoshino Hideaki , Okita Yutaka , Minatoya Kenji , Ueda Yuichi , Ogino Hitoshi
Published: July 2020

OBJECTIVES

The mortality of acute aortic dissection (AAD) remains high, and evidence-to-practice gaps exist in real-world treatment. We explored the first quality indicators (QIs) for AAD management and evaluated the associations between the achievement of these QIs and the outcome in a nationwide administrative database.

METHODS

A systematic search was performed to establish initial index items for QIs. An evaluation was performed through an expert consensus meeting using the Delphi method. We studied 18 348 patients who had AAD (type A: 10 131; type B: 8217) in the Japanese Registry of All Cardiac and Vascular Diseases database between April 2012 and May 2015. The associations between the achievement of QIs [categorized into tertiles (low, middle and high)] and in-hospital mortality were determined by multivariable mixed logistic regression analyses.

RESULTS AND CONCLUSION

We developed a total of 9 QIs (5 structural and 4 process). Lower achievement rates of QIs were significantly associated with higher in-hospital mortality in both types [type A = middle: odds ratio (OR) 4.03; 95% confidence interval (CI) 3.301–4.90; P < 0.001; low: OR 15.68; 95% CI 11.67–21.06; P < 0.001 vs high; type B = middle: OR 3.48; 95% CI 2.19–5.53; P < 0.001; low: OR 7.79; 95% CI 4.65–13.06; P < 0.001 vs high]. Various sensitivity analyses showed consistent results. High achievement rates of QIs were significantly associated with reduced in-hospital mortality. Evaluating each hospital’s management using QIs would help to equalize treatment quality and demonstrate the evidence-to-practice gaps in real-world treatments for AAD.
Superior vena cava aneurysm: an unusual mediastinal mass
Authors: Soares Souza Luciana Volpon , Souza Arthur Soares , Morales Márcia Maria , Marchiori Edson
Published: July 2020

Superior vena cava aneurysms are rare mediastinal vascular lesions. Aneurysms are classified as fusiform and saccular, with the latter being rarer than the former. We report the case of an asymptomatic 75-year-old woman who presented with a superior mediastinal mass. She underwent chest computed tomography angiography, which demonstrated a saccular aneurysm in the superior vena cava.
Late-Life Preparedness and Its Correlates: A Behavioral Perspective on Preparation
Authors: Kim-Knauss Yaeji , Lang Frieder R
Published: July 2020

Objectives

The present study examined the extent of late-life preparedness and its correlates. In accordance with behavior theories, we postulated that those who have prior experience with caregiving and who perceive such activities as more useful and less risky are more likely to engage in late-life preparatory activities. Because the perceived distance until aging-related life challenges become prevalent may play a role in late-life preparedness, we hypothesized that the effects of the correlates would vary depending on one’s subjective remaining life expectation (SRLE).

Methods

Building upon cross-sectional data including 581 German adults from 18 to 93 years, we fitted a hurdle model that separately analyzes the presence and variety of self-reported action engagement to better handle the zero-inflated count measure of preparatory activities.

Results

The results revealed that the effects of perceived utility, caregiving experience, and SRLE were significant for both the presence and variety of activities. SRLE was found to moderate the observed effects in the models: The effect of perceived utility on the presence of at least one late-life preparatory activity was larger for those with lower SRLE. In contrast, among those with higher SRLE, having provided care increased the variety of preparatory activities.

Discussion

Findings suggest that some of the examined psychosocial factors are similarly associated with both the presence of at least one and the variety of late-life preparatory activities, although the extent of their effects varies depending on one’s subjective life stage.
Development and Validation of a Workplace Age-Friendliness Measure
Authors: Eppler-Hattab Raphael , Doron Israel , Meshoulam Ilan
Published: July 2020

Background and Objectives

Measuring the extent to which the culture of organizations can be considered age-friendly is a significant anchor in the constructive inclusion process of older workers in workplaces, given the consistent aging of the workforce. Hence, the purpose of this research was to develop a novel, comprehensive, and theoretically driven measure of workplace age-friendliness.

Research Design and Methods

Three multiphased, multisourced studies were conducted: a qualitative assessment procedure and 2 separate quantitative field surveys of individual-level perceptions.

Results

A 24-item scale of workplace age-friendliness was developed, consisting of 4 dimensions that represent the different ways in which organizational culture aligns with an aging and older workforce: age-friendly core culture, development, wellness, and flexibility. Confirmatory factor analysis verified that a 4-factor structure is the most appropriate solution, with all dimensions having acceptable internal consistency. Preliminary evidence of construct validity is also presented.

Discussion and Implications

The measure developed in this study may serve researchers as well as practitioners in the field of aging and work. Further implications and limitations of using this instrument in future empirical study on workplace age-friendliness are discussed.
What Keeps Them Going, and What Gets Them Back? Older Adults’ Beliefs About Physical Activity Maintenance
Authors: Huffman Mary Katherine , Amireault Steve
Published: July 2020

Background and Objectives

The overall purpose of this article was to investigate beliefs related to physical activity maintenance among adults aged 60 years or older.

Research Design and Methods

Study 1 identified modal, salient behavioral, normative, and control beliefs using a free-response format. Study 2 was designed to gain a deeper understanding about these beliefs through in-depth semistructured interviews.

Results

Findings indicate that perceived physical and emotional benefits, scheduling and having a physical activity routine, social support, and features of indoor and outdoor locations are facilitating of maintenance. Some beliefs appear more relevant to sustained engagement in physical activity, while others may be more helpful for reengagement after 1 week of inactivity.

Discussion and Implications

This investigation raises new hypotheses for future research and provides insight for the use and adaptation of behavior change strategies that are potentially more acceptable and effective for the promotion of physical activity maintenance for older adults.
Relative survival scenarios: an application to undersized common sole (Solea solea L.) in a beam trawl fishery in the Mediterranean Sea
Authors: Masnadi Francesco , Armelloni Enrico Nicola , Guicciardi Stefano , Pellini Giulio , Raicevich Saša , Mazzoldi Carlotta , Scanu Martina , Sabatini Laura , Tassetti Anna Nora , Ferrà Carmen , Grati Fabio , Bolognini Luca , Domenichetti Filippo , Cacciamani Roberto , Calì Federico , Polidori Piero , Fabi Gianna , Luzi Francesca , Giovanardi Otello , Bernarello Valentina , Pasanisi Eugenia , Franceschini Gianluca , Breggion Cristina , Bozzetta Elisa , Sambo Andrea , Prioli Giuseppe , Gugnali Andrea , Piccioni Elena , Fiori Fabio , Caruso Fabrizio , Scarcella Giuseppe
Published: July 2020

Fishery discard survival depends on multiple conditions; caution is essential when survival study outputs are employed to support management decisions. The study presents a stepwise procedure, devised to estimate discard survival, that accounts for the variability characterizing commercial fishing practices. The procedure was applied to the first survival study performed onboard rapido trawlers targeting Solea solea in the Mediterranean Sea. Undersized specimens collected during sorting were assessed for vitality; some were retained for captive observation. The main drivers affecting discard survival at the time of catch sorting (immediate survival) were identified and used to outline four different operational conditions set (scenarios). Immediate survival in each scenario was subsequently modified by applying a hazard coefficient of survival after 5 days of captive observation in relation to each vitality class, thus obtaining relative survival estimates following discarding. Temperature and air exposure duration were found to exert a major effect on survival, with catch weight and seabed type being additional important factors. The relative survival rate showed an aggregate value of 22.9% (10.5–33.4%). Scenario approach can enhance our understanding of the stressors influencing discard survival. The outcomes are discussed to explore the potential applications of the procedure to the identification of mitigation strategies.
Comparison between the Khorana prediction score and Caprini risk assessment models for assessing the risk of venous thromboembolism in hospitalized patients with cancer: a retrospective case control study
Authors: Hu Yuehong , Li Xiaoqian , Zhou Haixia , Lin Ping , Zhang Jiarui , Huang Dong , Qi Min , Tang Yongjiang , Yi Qun , Liang Zong’an , Wang Maoyun
Published: July 2020

OBJECTIVES

This study aimed to evaluate the optimal risk assessment model (RAM) to stratify the risk of venous thromboembolism (VTE) in hospitalized patients with cancer. We examined and compared the VTE predictive ability of the Khorana score (KS) and the Caprini RAM in hospitalized cancer patients.

METHODS

We performed a retrospective case–control study among hospitalized cancer patients admitted to a comprehensive hospital in China from January 2015 to December 2016. A total of 221 cases were confirmed to have VTE during hospitalization and 221 controls were selected randomly. The Caprini RAM and KS were implemented and the individual scores of each risk factor were summed to generate a cumulative risk score. Meanwhile, the sensitivity, specificity, areas under curve of the receiver operating characteristic curve and calibration of these 2 models were analysed.

RESULTS

Significant differences were observed in risk factors between VTE and non-VTE hospitalized cancer patients and the VTE risk increased significantly with an increase in the cumulative KS or Caprini RAM score. A classification of ‘high risk’ according to KS and Caprini RAM was associated with 2.272-fold and 3.825-fold increases in VTE risk, respectively. However, the Caprini RAM could identify 82.4% of the VTE cases that required preventive anticoagulant therapy according to American College of Chest Physicians guidelines, whereas the KS could only identify 35.3% of the VTE cases. In addition, the areas under curve of Caprini RAM were significantly higher than those of the KS (0.705 ± 0.024 vs 0.581 ± 0.025, P < 0.001), with a best cut-off value of 5 score, which happened to be the cut-off value for high risk of VTE in Caprini RAM. Both Caprini RAM and KS showed an excellent calibration curve (0.612 vs 0.141, P > 0.05), but the risk of VTE events predicted by Caprini seemed closer to the observed risk of VTE events.

CONCLUSIONS

The Caprini RAM was found to be more effective than the KS in identifying hospitalized patients with cancer at risk of VTE.
Natural gas development, flaring practices and paediatric asthma hospitalizations in Texas
Authors: Willis Mary , Hystad Perry , Denham Alina , Hill Elaine
Published: July 2020

Background

Recent advancements in drilling technology led to a rapid increase in natural gas development (NGD). Air pollution may be elevated in these areas and may vary by drilling type (conventional and unconventional), production volume and gas flaring. Impacts of NGD on paediatric asthma are largely unknown. This study quantifies associations between specific NGD activities and paediatric asthma hospitalizations in Texas.

Methods

We leveraged a database of Texas inpatient hospitalizations between 2000 and 2010 at the zip code level by quarter to examine associations between NGD and paediatric asthma hospitalizations, where our primary outcome is 0 vs ≥1 hospitalization. We used quarterly production reports to assess additional drilling-specific exposures at the zip code-level including drilling type, production and gas flaring. We developed logistic regression models to assess paediatric asthma hospitalizations by zip code-quarter-year observations, thus capturing spatiotemporal exposure patterns.

Results

We observed increased odds of ≥1 paediatric asthma hospitalization in a zip code per quarter associated with increasing tertiles of NGD exposure and show that spatiotemporal variation impacts results. Conventional drilling, compared with no drilling, is associated with odds ratios up to 1.23 [95% confidence interval (CI): 1.13, 1.34], whereas unconventional drilling is associated with odds ratios up to 1.59 (95% CI: 1.46, 1.73). Increasing production volumes are associated with increased paediatric asthma hospitalizations in an exposure–response relationship, whereas associations with flaring volumes are inconsistent.

Conclusions

We found evidence of associations between paediatric asthma hospitalizations and NGD, regardless of drilling type. Practices related to production volume may be driving these positive associations.
Tandospirone, a Partial 5-HT1A Receptor Agonist, Administered Systemically or Into Anterior Cingulate Attenuates Repetitive Behaviors in Shank3B Mice
Authors: Dunn Jeffrey T , Mroczek Jessica , Patel Harsh R , Ragozzino Michael E
Published: July 2020

Background

Several cases of autism spectrum disorder have been linked to mutations in the SHANK3 gene. Haploinsufficiency of the SHANK3 gene contributes to Phelan-McDermid syndrome, which often presents an autism spectrum disorder phenotype along with moderate to severe intellectual disability. A SHANK3 gene deletion in mice results in elevated excitation of cortical pyramidal neurons that alters signaling to other brain areas. Serotonin 1A receptors are highly expressed on layer 2 cortical neurons and are known to have inhibitory actions. Serotonin 1A receptor agonist treatment in autistic cases with SHANK3 mutations and possibly other cases may restore excitatory and inhibitory balance that attenuates core symptoms.

Methods

A series of experiments investigated the effects of acute tandospirone treatment on spatial learning and self-grooming, subchronic treatment of tandospirone on self-grooming behavior, and the effect of tandospirone infusion into the anterior cingulate on self-grooming behavior.

Results

Only male Shank3B+/− mice exhibited a spatial learning deficit and elevated self-grooming. Acute i.p. injection of tandospirone, 0.01 and 0.06 mg/kg in male Shank3B+/− mice, attenuated a spatial acquisition deficit by improving sensitivity to positive reinforcement and reduced elevated self-grooming behavior. Repeated tandospirone (0.06 mg/kg) treatment attenuated elevated self-grooming behavior in male Shank3B+/− mice. Tandospirone injected into the anterior cingulate/premotor area reduced self-grooming behavior in male Shank3B+/− mice.

Conclusions

These results suggest that stimulation of cortical serotonin 1A receptors may reduce repetitive behaviors and cognitive impairments as observed in autism spectrum disorder, possibly by attenuating an excitation/inhibition imbalance. Further, tandospirone may serve as a treatment in autism spectrum disorder and other disorders associated with SHANK3 mutations.
Signatures of Topological Branched Covers
Authors: Geske Christian , Kjuchukova Alexandra , Shaneson Julius L
Published: July 2020

Let $X^4$ and $Y^4$ be smooth manifolds and $f: X\to Y$ a branched cover with branching set $B$. Classically, if $B$ is smoothly embedded in $Y$, the signature $\sigma (X)$ can be computed from data about $Y$, $B$ and the local degrees of $f$. When $f$ is an irregular dihedral cover and $B\subset Y$ smoothly embedded away from a cone singularity whose link is $K$, the second author gave a formula for the contribution $\Xi (K)$ to $\sigma (X)$ resulting from the non-smooth point. We extend the above results to the case where $Y$ is a topological four-manifold and $B$ is locally flat, away from the possible singularity. Owing to the presence of points on $B$ which are not locally flat, $X$ in this setting is a stratified pseudomanifold, and we use the intersection homology signature of $X$, $\sigma _{IH}(X)$. For any knot $K$ whose determinant is not $\pm 1$, a homotopy ribbon obstruction is derived from $\Xi (K)$, providing a new technique to potentially detect slice knots that are not ribbon.
Liquid Biopsy to Detect Circulating Tumor Cells: Is It Ready for a Value Proposition in Laboratory Medicine?
Authors: Cortés-Hernández Luis Enrique , Eslami-S Zahra , Alix-Panabières Catherine
Published: July 2020

The long-term effects of cancer on patient quality of life and its economic burden are important issues that need to be addressed. Therefore, it is critical to assess patient priorities and investigate the value proposition of clinical tests in this field. The minimally invasive liquid biopsy has attracted much attention because it allows serial sampling during cancer progression, and provides valuable biological information on the tumor biology and treatment response through the analysis of analytes in the blood, such as circulating tumor cells (CTCs). To introduce CTC analysis in daily clinical practice, it is still necessary to firmly establish its clinical benefits and extra value for clinical decision-making. A laboratory medicine value proposition of CTC medical applications can help to address these issues. In this review, we discuss the current evidence for a value proposition of CTC detection, isolation, and characterization using the available technologies, and we summarize the unmet requirements for the full integration of CTCs in the care pathway.
An application to support COVID-19 occupational health and patient tracking at a Veterans Affairs medical center
Authors: Fillmore Nathanael R , Elbers Danne C , La Jennifer , Feldman Theodore C , Sung Feng-Chi , Hall Robert B , Nguyen Vinh , Link Nicholas , Zwolinski Robert , Dipietro Svitlana , Miller Stephen J , Aleksanyan Anahit , Goryachev Sergey D , Corcoran Paul , Bergstrom Steven J , Parenteau Michael A , Sprague Robert S , Thornton David J , Driver Jane A , Strymish Judith M , Evans Stewart , Colonna Benjamin , Brophy Mary T , Do Nhan V
Published: July 2020

Objective

Reducing risk of coronavirus disease 2019 (COVID-19) infection among healthcare personnel requires a robust occupational health response involving multiple disciplines. We describe a flexible informatics solution to enable such coordination, and we make it available as open-source software.

Materials and Methods

We developed a stand-alone application that integrates data from several sources, including electronic health record data and data captured outside the electronic health record.

Results

The application facilitates workflows from different hospital departments, including Occupational Health and Infection Control, and has been used extensively. As of June 2020, 4629 employees and 7768 patients and have been added for tracking by the application, and the application has been accessed over 46 000 times.

Discussion

Data captured by the application provides both a historical and real-time view into the operational impact of COVID-19 within the hospital, enabling aggregate and patient-level reporting to support identification of new cases, contact tracing, outbreak investigations, and employee workforce management.

Conclusions

We have developed an open-source application that facilitates communication and workflow across multiple disciplines to manage hospital employees impacted by the COVID-19 pandemic.
Distribution of Fluvoxamine and Identification of the Main Metabolite in a Fatal Intoxication
Authors: Vignali Claudia , Moretti Matteo , Quaiotti Jessica , Freni Francesca , Tajana Luca , Osculati Antonio Marco Maria , Morini Luca
Published: July 2020

Fluvoxamine is a selective serotonin reuptake inhibitor, with a half-life of about 30 hours, that is commonly prescribed in the treatment of depression and obsessive and compulsive disorders. Though its more favorable adverse effect profile in comparison to tricyclic antidepressants, overdosages could lead to severe central nervous system depression. We hereby report the case of a 48-year-old woman with psychiatric disorders, who died in the Protected Community where she lived. An autopsy, during which multiorgan congestion and aspiration of gastric content were found, was performed 9 days after the death. Femoral and cardiac blood, urine and bile were collected for toxicological analysis. GC–MS, LC–MS-MS and LC–HRMS screenings were performed on blood samples. The analysis allowed to identify the following drugs: fluvoxamine, clotiapine, 7-aminoclonazepam, propranolol, gabapentin and haloperidol. Quantification of the detected drugs in blood was performed by means of a validated LC–MS-MS analytical procedure, and the following results were achieved: fluvoxamine (2.20 mg/L), gabapentin (41.00 mg/L), 7-aminoclonazepam (0.24 mg/L), clotiapine (0.07 mg/L), haloperidol (<0.01 mg/L) and propranolol (0.24 mg/L). Fluvoxamine concentration in blood exceeded ~10 times the upper limit of therapeutic blood levels (0.23 mg/L). Contributory causes of death, such as due to multiple drug use, however, cannot be excluded. The distribution of fluvoxamine in all biological fluids was evaluated and a postmortem redistribution effect was observed (C/P blood ratio: 1.86). Fluvoxamine acid metabolite was identified in urine, bile and in cardiac blood, through an LC–QTOF analytical procedure.
Registration method for maintenance-work support based on augmented-reality-model generation from drawing data
Authors: Lee Won-Hyuk , Lee Kyung-Ho , Lee Jung-Min , Nam Byeong-Wook
Published: July 2020

The importance of operations and maintenance (O&M) and piping inspection in shipbuilding and offshore plant industries has significantly increased recently. Therefore, this study proposes a system that uses augmented reality (AR) to support these operations. AR in O&M and inspection systems can increase work comprehension and efficiency by utilizing 3D graphics, instead of drawings, to describe specific work functions. To realize this improvement, the augmented model should correspond to the reality; if accurate registration is not achieved, it can disrupt the work functions. Therefore, marker-based AR is used to generate specific recognition objects and correct the location of the augmented model. However, owing to certain characteristics of the shipbuilding and offshore plant industries, the markers are likely to be damaged, and thus the cameras fail to clearly detect them. In this study, a 3D camera was used to generate a point cloud based on 3D image information. Accordingly, the area around the model to be detected was designated as the region of interest (ROI). Furthermore, it is difficult to support a high-end device environment because it is tested as a portable device that can be used in a working environment; therefore, superfluous data were removed by detecting the 3D edges in the ROI, thereby minimizing data operation. The scalability of this work was enhanced using the computer-aided design (CAD) file information extracted from the CAD tool (used in the shipbuilding industry) and converting it into a point cloud. The proposed system is expected to eliminate the issues related to understanding the O&M work by addressing registration errors that might occur in constrained environments and to improve the torsional phenomenon of the augmented models.
Geographic Distribution of Bacillus thuringiensis Cry1F Toxin Resistance in Western Bean Cutworm (Lepidoptera: Noctuidae) Populations in the United States
Authors: Coates Brad S , Abel Craig A , Swoboda-Bhattarai Katharine A , Palmquist Debra E , Montezano Débora G , Zukoff Sarah N , Wang Yangzhou , Bradshaw Jeffrey D , DiFonzo Christina D , Shields Elson , Tilmon Kelley J , Hunt Thomas E , Peterson Julie A
Published: July 2020

The western bean cutworm (WBC), Striacosta albicosta (Lepidoptera: Noctuidae), can be a severe pest of transgenic corn in the western Plains and Great Lakes regions of North America, including on hybrids expressing the Bacillus thuringiensis (Bt) Cry1F toxin. The level and geographic distribution of Cry1F resistance are not completely known. Neonate S. albicosta from 10 locations between Nebraska and New York state were subjected to dose–response trypsin-activated native Cry1F toxin overlay bioassays. In 2017, the mean estimated lethal concentration causing 50% larval mortality (LC50) ranged from 15.1 to 18.4 µg Cry1F cm−2, and were not significantly different among locations. In 2018, LC50 estimates at Scottsbluff, NE (22.0 µg Cry1F cm−2) and Watertown, NY (21.7 µg Cry1F cm−2) were significantly higher when compared to locations in Michigan (15.8 µg Cry1F cm−2). Significantly lower 14-day larval weight among survivors was correlated with higher Cry1F dose. Results from this study indicate that S. albicosta survivorship on purified Bt Cry1F toxin shows a relatively even distribution across the native and range expansion areas where seasonal field infestations typically occur.
Low Tunnels Reduce Insect Populations, Insecticide Application, and Chewing Insect Damage on Brussels Sprouts
Authors: Acharya Tej P , Welbaum Gregory E , Arancibia Ramón A
Published: July 2020

Low tunnels covered with spun-bonded fabric (row covers) provide season extension for vegetable production and also afford a physical barrier against airborne insects and other non-soil pests. Brussels sprouts, Brassica oleracea L. group Gemmifera (Brassicaceae), is a popular vegetable in local markets in Virginia; however, unprotected field production is severely affected by insect pest infestation. This study’s objective was to determine the level of protection low tunnels provide against insect infestation and leaf herbivory injury. The experiment was conducted at the Virginia Tech Eastern Shore Agricultural Research and Extension Center in Painter, Virginia. The experimental design was split-plot with polyethylene soil mulches (white or black) as whole plot factors and production systems (low tunnel or open field) as subplot factors. In this study, low tunnels reduced insect infestation and chewing herbivory leaf injury to Brussels sprouts. Compared to an unprotected open field, infestations of lepidopteran insects and harlequin bug, Murgantia histrionica (Hahn) (Hemiptera: Pentatomidae) were reduced on plants under low tunnels. However, aphids (Hemiptera: Aphidae) infestation occurred under low tunnels in fall. There was no effect of color mulches (white or black) and no interaction between tunnel and mulch color on insect infestation and chewing injury. Fewer insect infestations and feeding injury indicate that low tunnels can be an effective management tool for sustainable vegetable production.
A protective seam mining method by cutting roof with chainsaw arm machine
Authors: Kuang Tiejun , Tai Yang , Huo Bingjie , Xia Binwei , Zhang Yanqun , Xia Hongchun
Published: July 2020

Multiple-layered coal seams widely exist in main coal mining areas of China. When these coal seams are exploited, the pillar mining method is always employed. This leads to many coal pillars left in the upper coal seams as a protective barrier. As a result, these residual pillars will not only cause the loss of coal resources but also could trigger environmental issues and a serious of mine disasters. A theoretical model was built to analyse the effect of the residual pillars. From the theoretical model, it was found that four stress concentration areas were formed by the upper residual coal pillars. To address the issues of the residual coal pillars, Datong Coal Mine Group has developed an innovative technology of the roof cutting with a chainsaw. A new protective coal seam mining method using chainsaw roof-cutting technology is introduced. A numerical model is constructed to analyse the mining pressure distribution law in working face within the lower layer coal seam. From the numerical simulation, the new protective layer mining method could reduce about 15.2% of the advancing stress, which contributes a lot to controlling the mining pressure within the lower layer. The field measurement showed that the hydraulic support utilised at the site was at lower pressure levels, which proves the new protective seam mining method can significantly reduce the working face pressure.
Taxes and Custom: Tax Treaties as Evidence for Customary International Law
Authors: Braumann Céline
Published: July 2020

Scholars of public international law have not paid attention to international tax law in the past. This article seeks to fill this vacuum and to foster cross-field research by studying customary international law in international tax law. It assesses the value of international tax law’s most prominent feature for the identification of custom: the dense network of almost identical, bilateral double tax treaties. The primacy of source-based taxation for business profits serves as a test case for this purpose. The International Law Commission’s conclusions on the identification of customary international law constitute the theoretical reference point that informs the empirical analysis. Thus, this article simultaneously serves as a treadmill test to appraise whether the International Law Commission’s conclusions actually offer practical guidance. The analysis culminates in the conclusion that tax treaties have only little value for the identification of customary international law. First, tax treaties alone do not entail representative state practice. Second, tax treaties give rise to the pitfalls of the Baxter paradox. Third, the tax treaty network yields no evidence that any state practice originates from opinio juris. Judging by the evidence brought into play so far, states likely display uniform treaty practice in international taxation because they believe it is in their best interest, not due to any legal conviction.
A Beginner’s Guide to Collecting Questing Hard Ticks (Acari: Ixodidae): A Standardized Tick Dragging Protocol
Authors: Salomon Jordan , Hamer Sarah A , Swei Andrea
Published: July 2020

Tick-borne diseases are emerging globally, necessitating increased research and coordination of tick surveillance practices. The most widely used technique for active collection of host-seeking, human-biting tick vectors is ‘tick dragging’, by which a cloth is dragged across the top of the vegetation or forest floor and regularly checked for the presence of ticks. Use of variable dragging protocols limits the ability of researchers to combine data sets for comparative analyses or determine patterns and trends across different spatial and temporal scales. Standardization of tick drag collection and reporting methodology will greatly benefit the field of tick-pathogen studies. Based on the recommendations of the Center for Disease Control and Prevention and other ecological considerations, we propose that tick dragging should be conducted to sample at least 750 m2 along linear transects when habitat allows in a manner that reduces bias in the sampled area, and report density of each tick species and life stage separately. A protocol for constructing a standard drag cloth, establishing linear transects, and drag sampling is presented, along with a downloadable datasheet that can be modified to suit the needs of different projects. Efforts to align tick surveillance according to these standard best practices will help generate robust data on tick population biology.
Perceptions and Responses of Residents to the Nuisance Black Fly Simulium jenningsi (Diptera: Simuliidae) in the Mid-Atlantic United States
Authors: Wilson-Ounekeo Rebecca C , Lamp William O
Published: July 2020

Current management practices of nuisance black flies are conducted on an area-wide level and rely on the support of the public to implement programs. In Maryland, a vocal group of residents campaigned their representatives to begin a management program for the black fly Simulium jenningsi Malloch. To determine how residents in Maryland and its surrounding states perceived the severity of black fly nuisance, we deployed surveys online and in-person on the ways their outdoor activities were impacted and the preventive methods used to mitigate nuisance. Online respondents, those with children, and those who had lived in the region for a shorter amount of time were more likely to report black flies as ‘extremely annoying’. Quality-of-life concerns stemming from black fly swarms were primarily related to avoiding outdoor exercise and recreation. The majority of respondents used at least one method of personal protection against black fly annoyance, but satisfaction with any method was low. Methods used by respondents included the removal of standing water and rotting vegetation from their properties, indicating a lack of knowledge about black fly breeding habitats. The results contextualized the needs of residents in future management and topics for outreach efforts to address misconceptions about black fly biology. This study offers an example of the application of social science methodology in understanding the needs of stakeholders in area-wide pest management.
Body Mass Index and Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer
Authors: Floris Giuseppe , Richard François , Hamy Anne-Sophie , Jongen Lynn , Wildiers Hans , Ardui Jan , Punie Kevin , Smeets Ann , Berteloot Patrick , Vergote Ignace , De Croze Diane , Meseure Didier , Salomon Anne , Laé Marick , Reyal Fabien , Biganzoli Elia , Neven Patrick , Desmedt Christine
Published: July 2020

Background

High levels of stromal tumor-infiltrating lymphocytes (sTIL) are associated with increased pathological complete response (pCR) rate and longer survival after neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) patients. Here, we evaluated the value of sTIL in predicting pCR and explored prognosis in TNBC patients treated with neoadjuvant chemotherapy according to body mass index (BMI).

Methods

sTIL were scored centrally on pretreatment biopsies from 2 retrospective series of nonunderweight TNBC patients (n = 445). sTIL and BMI were considered as binary (sTIL: <30.0% vs ≥30.0%; BMI: lean vs overweight and obese) and continuous variables. Associations with pCR (ypT0/isN0) were assessed using logistic regression, and associations with event-free survival and overall survival were assessed using Cox regressions.

Results

236 (53.0%) patients were lean and 209 (47.0%) overweight and obese. pCR was achieved in 181 of 445 (41.7%) patients. Median sTIL was 11.0%, and 99 of 445 (22.2%) tumors had high sTIL. A statistically significant interaction between sTIL and BMI, considered as categorical or continuous variables, for predicting pCR was observed in the multivariable analysis (Pinteraction = .03 and .04, respectively). High sTIL were statistically significantly associated with pCR in lean (odds ratio [OR] = 4.24, 95% confidence interval [CI] = 2.10 to 8.56; P < .001) but not in heavier patients (OR = 1.48, 95% CI = 0.75 to 2.91; P = .26) in the multivariable analysis. High sTIL were further associated with increased event-free survival in lean (hazard ratio [HR] = 0.22, 95% CI = 0.08 to 0.62; P = .004) but not in heavier patients (HR = 0.53, 95% CI = 0.26 to 1.08; P = .08). Similar results were obtained for overall survival.

Conclusion

BMI is modifying the effect of sTIL on pCR and prognosis in TNBC patients treated with neoadjuvant chemotherapy.