bluuebunny/crossref_metadata_2025 huggingface dataset:
Protein C Deficiency Caused by a Novel Mutation in the PROC Gene in an Infant with Delayed Onset Purpura Fulminans
Authors: Al Harbi Mariam S. , El-Hattab Ayman W.
Published: September 2017

Protein C is an anticoagulant that is encoded by the PROC gene. Protein C deficiency (PCD) is inherited in an autosomal dominant or recessive pattern. Autosomal dominant PCD is caused by monoallelic mutations in PROC and often presents with venous thromboembolism. On the other hand, biallelic PROC mutations lead to autosomal recessive PCD which is a more severe disease that typically presents in neonates as purpura fulminans. In this report, we describe an 8-month-old infant with autosomal recessive PCD who presented with multiple lumps on his lower extremities at the age of 2 months and later developed purpura fulminans after obtaining a muscle biopsy from the thigh at the age of 5 months. Protein C level was less than 10% and PROC gene sequencing identified a novel homozygous missense mutation, c.1198G>A (p.Gly400Ser). Autosomal recessive PCD typically presents with neonatal purpura fulminans which is often fatal if not recognized and treated early. Therefore, early recognition is critical in preventing morbidity and mortality associated with autosomal recessive PCD.
Effect of Material Composition on Cohesion Characteristics of Styrene-Butadiene-Styrene-Modified Asphalt Using Surface Free Energy
Authors: Zhang Xing-jun , Feng Hui-xia , Li Xiao-min , Ren Xiao-yu , Lv Zhen-feng , Li Bo
Published: September 2017

Styrene-butadiene-styrene- (SBS-) modified asphalts were prepared by mixing different base asphalts, SBS modifier, extracting oil, and stabilizing agents. The contact angles between SBS-modified asphalt and distilled water, glycerol, and formamide were detected by the sessile drop method. Based on the surface energy theory, the surface free energy and cohesive power of SBS-modified asphalt were calculated. The influence of the raw materials composition, such as the virgin asphalt and SBS modifier types as well as the extracting oil and stabilizing agent contents, on the cohesive characteristics of SBS-modified asphalt was discussed. The results showed that virgin asphalt was compatible with SBS modifiers to improve cohesiveness. The cohesive power of branched SBS-modified asphalt was larger than that of linear SBS-modified asphalt. The cohesion of SBS-modified asphalt was improved as the SBS modifier and stabilizer contents increased but was reduced for excessive extraction oil contents. The cohesive characteristics of the SBS-modified asphalt were improved by the formation of stable three-dimensional network structures by cross-linking, winding, and grafting among different raw materials.
PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs
Authors: Mattox Austin K. , Lee Jina , Westra William H. , Pierce Robert H. , Ghossein Ronald , Faquin William C. , Diefenbach Thomas J. , Morris Luc G. , Lin Derrick T. , Wirth Lori J. , Lefranc-Torres Armida , Ishida Eiichi , Chakravarty Patrick D. , Johnson Lauren , Zeng Yang C. , Chen Huabiao , Poznansky Mark C. , Iyengar Neil M. , Pai Sara I.
Published: September 2017

Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cavity tumor. In this study, we examined the basis for the activity of programmed cell death protein (PD-1)-based immune checkpoint therapy that is being explored widely in head and neck cancers. Using multispectral imaging, we systematically investigated the OTSCC tumor microenvironment (TME) by evaluating the frequency of PD-1 expression in CD8+, CD4+, and FoxP3+ tumor-infiltrating lymphocytes (TIL). We also defined the cellular sources of PD-1 ligand (PD-L1) to evaluate the utility of PD-1:PD-L1 blocking antibody therapy in this patient population. PD-L1 was expressed in 79% of the OTSCC specimens examined within the TME. Expression of PD-L1 was associated with moderate to high levels of CD4+ and CD8+ TILs. We found that CD4+ TILs were present in equal or greater frequencies than CD8+ TILs in 94% of OTSCC and that CD4+FOXP3neg TILs were colocalized with PD-1/PD-L1/CD68 more frequently than CD8+ TILs. Both CD4+PD1+ and CD8+PD1+ TILs were anergic in the setting of PD-L1 expression. Overall, our results highlight the importance of CD4+ TILs as pivotal regulators of PD-L1 levels and in determining the responsiveness of OTSCC to PD1-based immune checkpoint therapy. Cancer Res; 77(22); 6365–74. ©2017 AACR.
Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA–MUF Interaction with ANXA2 and miR-34a
Authors: Yan Xinlong , Zhang Dongdong , Wu Wei , Wu Shuheng , Qian Jingfeng , Hao Yajing , Yan Fang , Zhu Pingping , Wu Jiayi , Huang Guanling , Huang Yinghui , Luo Jianjun , Liu Xinhui , Liu Benyu , Chen Xiaomin , Du Ying , Chen Runsheng , Fan Zusen
Published: September 2017

Accumulating evidence suggests that cancer-associated mesenchymal stem cells (MSC) contribute to the development and metastasis of hepatocellular carcinoma (HCC). Aberrant expression of long noncoding RNAs (lncRNA) has been associated with these processes but cellular mechanisms are obscure. In this study, we report that HCC-associated mesenchymal stem cells (HCC-MSC) promote epithelial–mesenchymal transition (EMT) and liver tumorigenesis. We identified a novel lncRNA that we termed lncRNA–MUF (MSC-upregulated factor) that is highly expressed in HCC tissues and correlated with poor prognosis. Depleting lncRNA–MUF in HCC cells repressed EMT and inhibited their tumorigenic potential. Conversely, lncRNA–MUF overexpression accelerated EMT and malignant capacity. Mechanistic investigations showed that lncRNA–MUF bound Annexin A2 (ANXA2) and activated Wnt/β-catenin signaling and EMT. Furthermore, lncRNA-MUF acted as a competing endogenous RNA for miR-34a, leading to Snail1 upregulation and EMT activation. Collectively, our findings establish a lncRNA-mediated process in MSC that facilitates hepatocarcinogenesis, with potential implications for therapeutic targeting. Cancer Res; 77(23); 6704–16. ©2017 AACR.
Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress
Authors: Wang Jia Yu , Liu Guang Zhi , Wilmott James S. , La Ting , Feng Yu Chen , Yari Hamed , Yan Xu Guang , Thorne Rick F. , Scolyer Richard A. , Zhang Xu Dong , Jin Lei
Published: September 2017

MTH1 helps prevent misincorporation of ROS-damaged dNTPs into genomic DNA; however, there is little understanding of how MTH1 itself is regulated. Here, we report that MTH1 is regulated by polyubiquitination mediated by the E3 ligase Skp2. In melanoma cells, MTH1 was upregulated commonly mainly due to its improved stability caused by K63-linked polyubiquitination. Although Skp2 along with other components of the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex was physically associated with MTH1, blocking the SCF function ablated MTH1 ubiquitination and expression. Conversely, overexpressing Skp2-elevated levels of MTH1 associated with an increase in its K63-linked ubiquitination. In melanoma cell lines and patient specimens, we observed a positive correlation of Skp2 and MTH1 expression. Mechanistic investigations showed that Skp2 limited DNA damage and apoptosis triggered by oxidative stress and that MAPK upregulated Skp2 and MTH1 to render cells more resistant to such stress. Collectively, our findings identify Skp2-mediated K63-linked polyubiquitination as a critical regulatory mechanism responsible for MTH1 upregulation in melanoma, with potential implications to target the MAPK/Skp2/MTH1 pathway to improve its treatment. Cancer Res; 77(22); 6226–39. ©2017 AACR.
Combined CDK4/6 and PI3Kα Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer
Authors: Teo Zhi Ling , Versaci Stephanie , Dushyanthen Sathana , Caramia Franco , Savas Peter , Mintoff Chris P. , Zethoven Magnus , Virassamy Balaji , Luen Stephen J. , McArthur Grant A. , Phillips Wayne A. , Darcy Phillip K. , Loi Sherene
Published: September 2017

New treatments for triple-negative breast cancer (TNBC) are urgently needed. Despite there being little evidence of clinical activity as single-agent therapies, we show that dual blockade of PI3Kα and CDK4/6 is synergistically effective against multiple RB1-wild-type TNBC models. Combined PI3Kα and CDK4/6 inhibition significantly increased apoptosis, cell-cycle arrest, and tumor immunogenicity and generated immunogenic cell death in human TNBC cell lines. Combination treatment also significantly improved disease control in human xenograft models compared with either monotherapy. Combined PI3Kα and CDK4/6 inhibition significantly increased tumor-infiltrating T-cell activation and cytotoxicity and decreased the frequency of immunosuppressive myeloid-derived suppressor cells in a syngeneic TNBC mouse model. Notably, combined PI3Kα and CDK4/6 inhibition, along with inhibition of immune checkpoints PD-1 and CTLA-4, induced complete and durable regressions (>1 year) of established TNBC tumors in vivo. Overall, our results illustrate convergent mechanisms of PI3Kα and CDK4/6 blockade on cell-cycle progression, DNA damage response, and immune-modulation and may provide a novel therapeutic approach for TNBC. Cancer Res; 77(22); 6340–52. ©2017 AACR.
NY-ESO-1 Vaccination in Combination with Decitabine Induces Antigen-Specific T-lymphocyte Responses in Patients with Myelodysplastic Syndrome
Authors: Griffiths Elizabeth A. , Srivastava Pragya , Matsuzaki Junko , Brumberger Zachary , Wang Eunice S. , Kocent Justin , Miller Austin , Roloff Gregory W. , Wong Hong Yuen , Paluch Benjamin E. , Lutgen-Dunckley Linda G. , Martens Brandon L. , Odunsi Kunle , Karpf Adam R. , Hourigan Christopher S. , Nemeth Michael J.
Published: September 2017

Purpose: Treatment options are limited for patients with high-risk myelodysplastic syndrome (MDS). The azanucleosides, azacitidine and decitabine, are first-line therapy for MDS that induce promoter demethylation and gene expression of the highly immunogenic tumor antigen NY-ESO-1. We demonstrated that patients with acute myeloid leukemia (AML) receiving decitabine exhibit induction of NY-ESO-1 expression in circulating blasts. We hypothesized that vaccinating against NY-ESO-1 in patients with MDS receiving decitabine would capitalize upon induced NY-ESO-1 expression in malignant myeloid cells to provoke an NY-ESO-1–specific MDS-directed cytotoxic T-cell immune response.

Experimental Design: In a phase I study, 9 patients with MDS received an HLA-unrestricted NY-ESO-1 vaccine (CDX-1401 + poly-ICLC) in a nonoverlapping schedule every four weeks with standard-dose decitabine.

Results: Analysis of samples serially obtained from the 7 patients who reached the end of the study demonstrated induction of NY-ESO-1 expression in 7 of 7 patients and NY-ESO-1–specific CD4+ and CD8+ T-lymphocyte responses in 6 of 7 and 4 of 7 of the vaccinated patients, respectively. Myeloid cells expressing NY-ESO-1, isolated from a patient at different time points during decitabine therapy, were capable of activating a cytotoxic response from autologous NY-ESO-1–specific T lymphocytes. Vaccine responses were associated with a detectable population of CD141Hi conventional dendritic cells, which are critical for the uptake of NY-ESO-1 vaccine and have a recognized role in antitumor immune responses.

Conclusions: These data indicate that vaccination against induced NY-ESO-1 expression can produce an antigen-specific immune response in a relatively nonimmunogenic myeloid cancer and highlight the potential for induced antigen-directed immunotherapy in a group of patients with limited options. Clin Cancer Res; 24(5); 1019–29. ©2017 AACR.

See related commentary by Fuchs, p. 991
Restricted Delivery of Talazoparib Across the Blood–Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma
Authors: Kizilbash Sani H. , Gupta Shiv K. , Chang Kenneth , Kawashima Ryo , Parrish Karen E. , Carlson Brett L. , Bakken Katrina K. , Mladek Ann C. , Schroeder Mark A. , Decker Paul A. , Kitange Gaspar J. , Shen Yuqiao , Feng Ying , Protter Andrew A. , Elmquist William F. , Sarkaria Jann N.
Published: September 2017

Poly ADP-ribose polymerase (PARP) inhibitors, including talazoparib, potentiate temozolomide efficacy in multiple tumor types; however, talazoparib-mediated sensitization has not been evaluated in orthotopic glioblastoma (GBM) models. This study evaluates talazoparib ± temozolomide in clinically relevant GBM models. Talazoparib at 1–3 nmol/L sensitized T98G, U251, and GBM12 cells to temozolomide, and enhanced DNA damage signaling and G2–M arrest in vitro. In vivo cyclical therapy with talazoparib (0.15 mg/kg twice daily) combined with low-dose temozolomide (5 mg/kg daily) was well tolerated. This talazoparib/temozolomide regimen prolonged tumor stasis more than temozolomide alone in heterotopic GBM12 xenografts [median time to endpoint: 76 days versus 50 days temozolomide (P = 0.005), 11 days placebo (P < 0.001)]. However, talazoparib/temozolomide did not accentuate survival beyond that of temozolomide alone in corresponding orthotopic xenografts [median survival 37 vs. 30 days with temozolomide (P = 0.93), 14 days with placebo, P < 0.001]. Average brain and plasma talazoparib concentrations at 2 hours after a single dose (0.15 mg/kg) were 0.49 ± 0.07 ng/g and 25.5±4.1 ng/mL, respectively. The brain/plasma distribution of talazoparib in Bcrp−/− versus wild-type (WT) mice did not differ, whereas the brain/plasma ratio in Mdr1a/b−/− mice was higher than WT mice (0.23 vs. 0.02, P < 0.001). Consistent with the in vivo brain distribution, overexpression of MDR1 decreased talazoparib accumulation in MDCKII cells. These results indicate that talazoparib has significant MDR1 efflux liability that may restrict delivery across the blood–brain barrier, and this may explain the loss of talazoparib-mediated temozolomide sensitization in orthotopic versus heterotopic GBM xenografts. Mol Cancer Ther; 16(12); 2735–46. ©2017 AACR.
Short-Infusion Trabectedin in Heavily Pretreated Ovarian Cancer Patients: A Single-Institution Experience
Authors: Marchetti Claudia , Musella Angela , Romito Alessia , Vertechy Laura , Palaia Innocenza , Di Donato Violante , Boccia Serena , De Felice Francesca , Monti Marco , Muzii Ludovico , Benedetti Panici Pierluigi
Published: September 2017

Objective: The aim of this study was to assess the efficacy and tolerability of trabectedin given every 10 days as a single agent in recurrent ovarian cancer after 3 prior regimens. Method: Trabectedin 0.6 mg/m2 was administered as a 3-h infusion every 10 days on a 21-day cycle. The study population was compared to patients treated with weekly paclitaxel 80 mg/m2 intravenously on days 1, 8, 15, and 22 every 4 weeks. Results: We identified 34 patients previously submitted to at least 3 lines of chemotherapy who received single-agent trabectedin between 2010 and 2015. They were matched with a historical series of 34 patients who received weekly paclitaxel. No significant differences in response rate were found. Median progression-free survival was 4 months; 5 months in the trabectedin group and 4 months in the paclitaxel group. Overall survival (OS) was 13 months for the trabectedin group and 7 months for the paclitaxel group (p = 0.015). Patients who received platinum after trabectedin had a significant OS increase compared to those who received platinum after paclitaxel (18 vs. 9 months, respectively; p = 0.009). The most frequent drug-related grade 3/4 toxicities were reversible hepatic toxicity, neutropenia, anemia, thrombocytopenia, and gastrointestinal toxicity. Conclusion: Single-agent trabectedin every 10 days is an active treatment with a manageable toxicity profile in heavily pretreated advanced relapsed ovarian cancer patients.
Intersubjectivity and Psychopathology in the Schizophrenia Spectrum: Complicated We, Compensatory Strategies, and Self-Disorders
Authors: Henriksen Mads Gram , Nilsson Lars Siersbæk
Published: September 2017

Recent studies in phenomenological psychopathology emphasize the importance of intersubjectivity for our understanding of schizophrenia. Yet, the central role of the “we” in social experience and engagement is largely absent from this literature. Our study explores the relation between psychopathology and intersubjectivity in the schizophrenia spectrum through the prism of the “we.” First, we explore the role of intersubjectivity in the current schizophrenia spectrum definitions and discuss the main contemporary research trends. Second, we recollect some of the classical accounts of schizophrenia, which offer a different perspective on the pervasive and often persistent intersubjective difficulties in these conditions. Third, capitalizing on recent advances in collective intentionality studies, we present and discuss a conceptual framework of the “we” and of how the “we” may be disrupted in schizophrenia. Through this framework and with the use of clinical vignettes, we elicit 3 compensatory strategies, which, we suggest, reflect a fragile sense of “we” in the schizophrenia spectrum, i.e. (i) positive withdrawal, (ii) imposing a goal-oriented, spatiotemporal structure on intersubjective engagement, and (iii) preferring social activities with a clear attribution of social roles and rules. Finally, we discuss the relation between anomalous self-experiences (i.e. self-disorders) and the complicated “we.”
Next-Generation Sequencing in Gynaecological Tumours: The Prognostic and Predictive Value of the Most Common Mutations Found in Ovarian, Endometrial, and Cervical Tumours: Literature Review and the University Medical Centre Utrecht Next-Generation Sequencing Data
Authors: van Winkel Eline , de Leng Wendy W.J. , Witteveen Petronella O. , Jonges Trudy , Willems Stefan M. , Langenberg Marlies H.G.
Published: September 2017

Objective: To investigate whether next-generation sequencing (NGS) in ovarian and endometrial tumours can discover mutations with a relevant prognostic or predictive value. Methods: After a literature search, selected studies were critically appraised using the Quality in Prognostic Studies tool. Data on mutation incidence and correlations with prognostic and predictive items were extracted from relevant studies and compared to our own cohort consisting of 28 patients analysed using NGS. Results: Eight out of 739 articles were found eligible, including different tumour types. Prevalence of mutations in the KRAS gene ranged between 5.34 and 58.8% in ovarian cancer. Two studies showed a significant correlation between KRAS mutations and an improved disease free- and overall survival. Clinical data were available for 17 of our patients, mostly cases of endometrial carcinomas. KRAS, PIK3CA, CTNNB1, and TP53 were the most frequently mutated genes in endometrial carcinomas, and PTEN and CTNNB1 correlated with a higher FIGO stage. Conclusion: In the ovary KRAS mutation is associated with type I ovarian tumours (low-grade serous, mucinous, endometrioid, and clear-cell) and may seem to have a more favourable prognosis. The prognostic value of TP53 is still controversial. In endometrial tumours, PTEN shows a positive correlation with better prognosis. PIK3CA may have a correlation with poorer prognosis. CTNNB1 mutations in endometrial carcinomas could predict a worse prognosis.
Trans-Fatty Acids and Cardiovascular Disease: Urgent Need for Legislation
Authors: Wilczek Mateusz M. , Olszewski Robert , Krupienicz Andrzej
Published: September 2017

Hydrogenated oils containing trans-fatty acids (TFA) are used to produce margarine and various processed foods. TFA affect serum lipid levels, fatty acid metabolism, and endothelial function. High TFA intake is linked to increased all-cause mortality, coronary heart disease mortality, and cardiovascular disease (CVD) incidence. Denmark was the first country to introduce a law that limited TFA content in food; this action led to lower CVD mortality. So far 7 European countries have followed this practice, in a few others the food industry voluntarily reduced TFA use. The issue remains mostly unaddressed in the rest of the world. Legal TFA limits should be commonly established as they are the optimal solution considering both CVD prevention and the associated cost savings in public healthcare.
MicroRNA-125a Regulates Cell Proliferation Via Directly Targeting E2F2 in Osteosarcoma
Authors: Tao Tieying , Shen Qinrong , Luo Jianmin , Xu Yang , Liang Wenqing
Published: September 2017

Background/Aims: Increasing evidence has shown that miR-125a plays important role in human cancer progression. However, little is known about the function of miR-125a in osteosarcoma. Methods: The expression of miR-125a in osteosarcoma tissues and cell lines were examined by qRT-PCR. The biological role of miR-125a in osteosarcoma cell proliferation was examined in vitro. The targets of miR-125a were identified by a dual-luciferase reporter assay. Results: The results showed that the expression of miR-125a expression is significantly lower in osteosarcoma tissues and cell lines. Survival curves showed that the survival of patients in high miR-125a expression was significantly longer than that of patients with low miR-125a expression, and multivariate analysis suggested that miR-125a is an independent prognostic factor for osteosarcoma patients. In addition, it was found in this study that miR-125a can inhibit the growth of osteosarcoma cells. The dual-luciferase reporter assay demonstrated that E2F2 is a novel target gene for miR-125a. In addition, in a recovery experiment, it was shown that miR-125a inhibits the biological function of osteosarcoma cells by inhibiting the expression of E2F2. Conclusion: Our results suggest that miR-125a acts as a tumor suppressor via regulation of E2F2 expression in osteosarcoma progression, and miR-125a may represent a novel therapeutic target for the treatment of osteosarcoma.
Language Prediction Is Reflected by Coupling between Frontal Gamma and Posterior Alpha Oscillations
Authors: Wang Lin , Hagoort Peter , Jensen Ole
Published: September 2017

Readers and listeners actively predict upcoming words during language processing. These predictions might serve to support the unification of incoming words into sentence context and thus rely on interactions between areas in the language network. In the current magnetoencephalography study, participants read sentences that varied in contextual constraints so that the predictability of the sentence-final words was either high or low. Before the sentence-final words, we observed stronger alpha power suppression for the highly compared with low constraining sentences in the left inferior frontal cortex, left posterior temporal region, and visual word form area. Importantly, the temporal and visual word form area alpha power correlated negatively with left frontal gamma power for the highly constraining sentences. We suggest that the correlation between alpha power decrease in temporal language areas and left prefrontal gamma power reflects the initiation of an anticipatory unification process in the language network.
Transformation of a New Chinese Immigrant Community in the United States: A Case Study in Flushing, New York (美國新華人移民社區的轉型—以紐約法拉盛為探討中心)
Authors: Chen (陳靜瑜) Christine Chin-yu
Published: September 2017

Early Chinese immigrants in America centered on the Chinatown, which had fixed blocks and scope of activities. The distinguishing features of its ethnic culture and economy were formed by the ethnic Chinese immigrants who dwelt there. The Chinatown has become identified with the early Chinese immigrants and become one of the most unique residential areas for any ethnic group. Ever since the 1965 amendments to the American Immigration and Nationality Act, however, new Chinese arrivals no longer inhabit Chinatowns after they reach the United States. Without stationary blocks and scopes of activities, new Chinese immigrant communities have become enclaves accommodating multiple ethnic groups instead of one particular ethnicity. These communities are closely connected to a variety of ethnic features and have a tremendously different appearance from that of Chinatown. This transformation is still in progress and has been widely-considered by many scholars researching overseas ethnic Chinese immigrants. Flushing, in New York, is the largest Chinese immigrant community in the twenty-first century. This essay takes it as a case study to look into the evolution of Chinese immigrant communities in the United States.

早期美國華人移民以唐人街為中心，它有固定的街區，一定的活動範圍。老移民住在這個範圍內，形成它鮮明的族裔文化和經濟特色，贏得了早期華人移民的認同，成為美國最具特色的族裔聚居區之一。自1965年新移民法修改後，新移民移入美國，不再以唐人街為居住區域，新華人移民社區無固定的街區，無固定的活動範圍，無單一的族裔聚集區，甚或是多族裔聚集的區域，靠著族裔特色融匯在一起，與過去的唐人街特色迥異，這種改變正在持續中，也是現今研究海外華人的學者關注的課題。本文欲藉由21世紀全球最大的華人移民社區—紐約的法拉盛（Flushing） 為例，探討美國華人移民社區的演變。 (This article is in English).
Nippostrongylus smalesae sp. nov. (Nematoda: Heligmonellidae) collected from Maxomys whiteheadi (Rodentia: Muridae) of Sumatra, Indoneisa
Authors: HASEGAWA HIDEO , DEWI KARTIKA , FITRIANA YULI S. , ASAKAWA MITSUHIKO
Published: September 2017

Nippostrongylus smalesae sp. nov. (Nematoda: Heligmonellidae) is described from a murid Maxomys whiteheadi collected in Riau, Sumatra, Indonesia. It is readily distinguished from all of the known congeners by having the ray 3 widely diverged distally from the ray 4 in the left lobe of bursa copulatrix. This is the tenth named species of Nippostrongylus. The same species but with slight morphological difference was also found from M. whiteheadi and Niviventer cremoriventer in Kalimantan (Borneo Island), suggesting wide geographical distribution on the Sundashelf islands.
Four new species of the genus Trachelas L. Koch, 1872 and the first record of T. vulcani Simon, 1896 from South-West China (Araneae: Trachelidae)
Authors: JIN CHI , YIN XIANGCHU , ZHANG FENG
Published: September 2017

Trachelas vulcani Simon, 1896 is recorded from China for the first time. The type species, T. minor O. Pickard-Cambridge, 1872, is redescribed based on specimens from Macedonia. Additionally, four new species of the spider genus Trachelas are described and illustrated: Trachelas brachialis sp. n. (♂, ♀), T. gigapophysis sp. n. (♂), T. gaoligongensis sp. n. (♀) and T. shilinensis sp. n. (♀).
Athanas alpheusophilus sp. nov. (Decapoda: Alpheidae)—a new Alpheus-associated shrimp from the Russian coast of the Sea of Japan
Authors: MARIN IVAN
Published: September 2017

A new alpheid shrimp, Athanas alpheusophilus sp. nov., is described on the basis of numerous mature specimens collected from burrows of Alpheus brevicristatus De Haan, 1844 in Vityaz Bay, which is part of Posjeta Bay on the Russian side of the Sea of Japan. The new species belongs to “Athanas dimorphus” species complex and can be clearly separated from Athanas japonicus Kubo, 1936 and relative species by unique combination of morphological features of male and female pereiopods I (chelipeds) and some other features. Moreover, Athanas alpheusophilus sp. nov. is the first species of the genus Athanas Leach, 1814 reported as a symbiont of larger burrowing snapping shrimps of the genus Alpheus Fabricius, 1798 (Crustacea: Decapoda: Alpheidae). Some taxonomic remarks on A. japonicus and related species are provided and Athanas lamellifer Kubo, 1940 is revalidated based on morphology of the male pereiopods I.
Subsurface Lateral Heat Flux within the Heterogeneous Surface of a Subtropical Wetland and Its Potential Contribution to Energy Imbalance
Authors: Cui Wenhui , May Chui Ting Fong
Published: September 2017

In the eddy covariance technique, lateral heat fluxes in the atmosphere, surfaces, and subsurfaces are often ignored under the assumption of a homogeneous surface. Among lateral heat fluxes, the surface and subsurface fluxes, which might affect the surface energy balance closure over a heterogeneous surface, are less studied. Many wetlands are heterogeneous, with a mix of vegetated areas and shallow open water. This study examined the subsurface lateral heat fluxes between a reed bed and the adjacent water of a subtropical wetland in Hong Kong, China. An array of temperature and water-level sensors was installed in the soil of the reed bed and in the adjacent water. An eddy covariance system was also set up on the reed bed. The subsurface lateral heat fluxes were largest close to the interface of the reed bed and water and decreased as the distance from the interface increased, as expected. However, the subsurface lateral heat fluxes could not account for the energy imbalance because their magnitudes were relatively small and fluctuated in phase with the energy budget residuals during the winter months. The uncertainties of the turbulent fluxes and the lateral heat fluxes were estimated to be 10%–20% and 10%–30%, respectively. This study explored another potential reason behind the energy imbalance of the eddy covariance technique. The results enhance the understanding of water and energy exchanges between a terrestrial biotope and the surrounding water, which might further generate insights into the biochemical processes in wetlands.
How Much Does “Backing Aloft” Actually Impact a Supercell?
Authors: Parker Matthew D.
Published: September 2017

Among forecasters and storm chasers, there is a common perception that hodographs with counterclockwise curvature or kinking in the midlevels (sometimes called backing aloft or veer–back–veer profiles) are unfavorable for long-lived supercells and tornadoes. This study reviews and then evaluates several possible explanations for the purported negative effect of backing aloft. As a controlled hypothesis test, simulated supercells are initiated within a range of idealized wind profiles, many of which include representative counterclockwise kinks or bends in their hodographs. In these experiments, the short-term, direct impacts of backing aloft upon supercell maintenance are generally small. Backing aloft does modify the component of vertical accelerations linked to updraft–shear interactions, but these changes generally occur well above the level of free convection (LFC), and they are generally offset by substantial upward accelerations attributable to other processes (e.g., within-storm rotation and positive buoyancy). In these simulations, the longevity of isolated supercells seems to be most directly hindered in environments with very low storm-relative helicity (SRH) or else (for a line of supercells) substantial along-line flow in the upper troposphere. Although these two disrupting properties can accompany backing aloft, they are neither universally nor exclusively associated with it. From the perspective of storm dynamics, it seems advisable to focus on SRH and along-line flow in the environment, rather than the presence (or absence) of backing aloft in the wind profile.
Sialendoscopy in the Management of Radioiodine Induced Sialadenitis: A Systematic Review
Authors: Cung Thai-Duong , Lai Wanda , Svider Peter F. , Hanba Curtis , Samantray Julie , Folbe Adam J. , Shkoukani Mahdi , Raza Syed Naweed
Published: September 2017

Objectives:

Salivary gland dysfunction as a consequence of radioiodide ablation is present in as many as two-thirds of patients, and unfortunately, many of these individuals do not respond to conservative measures. Sialendoscopy as a minimally invasive therapeutic modality may have utility in the treatment of radioiodide induced sialadenitis (RAIS). Our aim was to explore whether sialendoscopy resulted in clinical improvement in patients with RAIS.

Methods:

A systematic review of studies on sialendoscopy for RAIS was conducted using MEDLINE database, Embase, and Cochrane Library. The outcomes of interest included the proportion of patients demonstrating clinical improvement after intervention, patient demographics, radiation dose, specific procedural variations, specific salivary gland, failure rate, and recurrence.

Results:

Eight studies met inclusion criteria. Data reviewed showed an increased predilection of parotid sialadenitis relative to submandibular gland sialadenitis. All but 2 studies employed sialendoscopy only after failure of conservative measures. An overall rate of clinical improvement ranging from 75% to 100% was reported.

Conclusion:

This systematic review encompassing 122 patients represents the largest pooled sample to date of patients undergoing sialendoscopy for RAIS. Sialendoscopy represents an invaluable minimally invasive modality that may obviate the need for more invasive surgery as intervention was associated with a high success rate.
Mujerista Leadership in the Service of Social Justice
Authors: Vasquez Melba J. T.
Published: September 2017

In this article, I posit that diverse leaders in terms of culture, race, ethnicity, gender, and sexual orientation are needed in all aspects of society. Diversity in leadership is a compelling interest for society, and I propose that, in particular, those with mujerista, womanist, or feminist internalized attitudes and identities have much to offer given their lived experiences, consequential awareness, and commitment to social justice. These qualities lead to effective leadership. I present Supreme Court Justice Sonia Sotomayor as a case in point—a woman who exemplifies all of these qualities.
Black Lives Matter: A Call to Action for Counseling Psychology Leaders
Authors: Hargons Candice , Mosley Della , Falconer Jameca , Faloughi Reuben , Singh Anneliese , Stevens-Watkins Danelle , Cokley Kevin
Published: September 2017

Police brutality and widespread systemic racism represent historical and current sources of trauma in Black communities. Both the Black Lives Matter movement and counseling psychology propose to confront these realities at multiple levels. Black Lives Matter seeks to increase awareness about systemic racism and promote resilience among Black people. Counseling psychology states values of multiculturalism, social justice, and advocacy. Executive leadership in counseling psychology may seek to promote racial justice, yet struggle with how to participate in Black Lives Matter movements and address racial discrimination within larger systems spontaneously and consistently. However, counseling psychology trainees and professionals are actively involved in the Black Lives Matter movement, leading the way forward. Through the framework of spontaneity in social movements, this manuscript highlights what counseling psychologists are currently contributing to Black Lives Matter and makes recommendations that build on the opportunity counseling psychologists have for further involvement in the movement.
Agglomeration and assemblage: Deterritorialising urban theory
Authors: Dovey Kim , Rao Fujie , Pafka Elek
Published: September 2017

In two recent papers Storper and Scott have sought to counter the rise of assemblage thinking in urban studies, suggesting it is indeterminate, jargon-ridden and particularist – that it lacks a critique of power. Against such approaches they propose the ‘nature of cities’ as an ‘urban land nexus’ driven by the economics of agglomeration. In this paper we respond, largely agreeing on jargon yet arguing that assemblage is a form of critical urban thinking that holds potential for a general but open theory of urbanity. We also suggest that many parts of Scott and Storper’s own work are entirely compatible with assemblage thinking, including concepts such as urban ‘bundling’ and ‘buzz’. Agglomeration theory explains why cities emerge and grow where they do but is weak on issues of scale and morphology. Assemblage thinking embodies capacities to expand urban studies through a better engagement with multi-scale relations, gearing the economics of agglomeration to the study of urban morphology; understanding cities in terms of their possible futures as well as actual conditions. We call for more open and productive interfaces between research disciplines and approaches – a deterritorialisation of urban theory. The choice is not between agglomeration and assemblage, it is between the singular and the multiple.
A dance of ambiguous constructions: White South African transracial adoptive and foster mothers’ discourses on race
Authors: dos Santos Andeline , Wagner Claire
Published: September 2017

‘Transracial’ adoption and fostering offer fertile ground for exploring how constructions of race can operate. This qualitative study engaged in a discourse analysis of interviews with 17 South African mothers identifying as White who have adopted and who foster transracially. Focus was placed on how they talk about race through their discussions of mothering. Findings highlight how race is constructed largely in an ambivalent manner and how aversive racism can coexist with intentionally devoted mothering. Some mothers in this study, however, do assume a consciously reflexive stance in their deconstruction of race.
The Changing Nature of Reserve Cohesion: A Study of Future Reserves 2020 and British Army Reserve Logistic Units
Authors: Bury Patrick
Published: September 2017

For too long military cohesion scholars have focused on regular infantry forces. This article examines the impact of the Future Reserves 2020 (FR20) policy on cohesion, professionalism, and discipline among British reserve logisticians. In doing so, it makes three significant contributions to the cohesion literature. Firstly, addressing scholars’ almost exclusive focus on regular infantry, it presents the first academic study on cohesion in British reserve logistics forces. Secondly, in detailing how cohesion in these forces is based on interpersonal rather than professional bonds, it argues that the locus of cohesion and discipline in these forces is different to that recently identified in the regular professional infantry. Thirdly, the article argues that while FR20 is gradually changing many of British reserve norms, the organizational realities of reserve service continue to limit the policy's impact. The evidence presented may be theoretically applicable to other reserve and noncombat forces in future cohesion research.
The power of stories: Facilitating social communication in children with limited language abilities
Authors: Brinton Bonnie , Fujiki Martin
Published: September 2017

Children with limited language expression and comprehension abilities are at risk for academic failure, particularly in literacy acquisition. In addition, these children often have poor social outcomes, including difficulty forming friendships, social exclusion, withdrawal, and victimization. The academic and social difficulties that these children experience are associated with their poor language processing skills, limited conversational ability, and weak social and emotional knowledge. A social communication approach utilizing children’s literature is suggested as one approach to address these three areas simultaneously. This approach involves sharing books with a strong story structure, rich social and emotional content, and engaging illustrations. Flexible scripts are created to guide interventionists to elicit the production of complex sentence structures, highlight conversational cooperation, and facilitate emotion understanding. To provide continuity of instruction, these bibliotherapeutic procedures can be implemented by special service providers in intervention sessions as well as by teachers in general classroom activities.
The impact of bibliotherapy superheroes on youth who experience parental absence
Authors: Betzalel Nurit , Shechtman Zipora
Published: September 2017

As one key element of establishing a superhero persona, many superhero myths are based on the principle of experiencing parental loss at an early age. This study examined the impact of group bibliotherapy using superhero stories with children and adolescents who have experienced parental absence. The 187 participants who resided in foster care were divided into three experimental conditions: Bibliotherapy with superhero stories, bibliotherapy without superheroes, and no treatment. Four dependent variables were tested in a pre–post–follow-up design: Anxiety, violent behavior, aggression, and future orientations. Results indicated that the strongest desired outcomes were obtained in the superhero treatment condition: There were significant positive changes on all four dependent variables, with changes sustained at follow-up. In the other treatment condition, significant changes were observed on only two variables and were not sustained at follow-up. No significant changes were observed in the non-treatment group. On the future orientations scale, only children in the superhero condition indicated change: They gained in future goals and had reduced fantasies about home. In general, results support the effectiveness of bibliotherapy with children and clearly point to the unique contribution of bibliotherapy content tailored to children's specific needs.
Preserving Guam's culture with culturally responsive children's stories
Authors: Jackson Marilyn Malloy , Heath Melissa Allen
Published: September 2017

Regardless of where schools are located, teachers face the challenge of teaching and mentoring children, not only in academic achievement but in social emotional development. When faced with challenges, young children are especially vulnerable because they lack the life experience and developmental maturity to adequately cope. Relying on the lead author's personal experiences in leading Guam's university teacher preparation program and in developing an early childhood education literacy program, this article demonstrates how teachers adapted popular Mother Goose nursery rhymes, tales, and local indigenous stories, making stories relevant to the local culture in Guam. Stories, specifically aligned with local cultures and traditions, are recommended as an intervention strategy to strengthen children's emerging literacy skills and to strengthen children's self-identity and resilience. In particular, offering opportunities for students to see oneself and one's culture in children's literature builds cultural esteem and a sense of community.
What Doesn’t Kill You Makes You Stronger: How Teams Rebound From Early-Stage Relationship Conflict
Authors: Thiel Chase E. , Harvey Jaron , Courtright Stephen , Bradley Bret
Published: September 2017

Past research overwhelmingly suggests that relationship conflict (RC) has negative effects on team processes and performance. However, little research has investigated the effects of RC through a temporal lens with an eye toward overcoming the short-term deleterious consequences of RC. Integrating threat rigidity and threat regulation theories, we first argue that RC disrupts team processes over time because members feel threatened and, second, that cognitive reappraisal, as an emotion regulation strategy, is a threat regulation mechanism by which teams can overcome RC. Specifically, we examine the influence of early-stage RC on team process trajectories, the moderating effect of team-level cognitive reappraisal on these trajectories, and the team performance implications of team processes. Testing our predictions in both field and laboratory studies with conditional linear growth modeling, we show that while teams with high early-stage RC are lower initially on critical team processes (coordination and interpersonal processes), they incrementally “rebound” from these lower levels of team processes if team members have a tendency to cognitively reappraise past affective events. Further, we find that changes in perceived threat stemming from early-stage RC drives these effects. Finally, we find that as a result of managing early-stage RC through cognitive reappraisal, team performance does not suffer. Overall, these results suggest that teams can overcome the negative effects of early-stage RC by addressing underlying appraisals of threat, and that they may benefit in the long run from the struggle of doing so. Implications of these findings and directions for future research are discussed.
Play at Work: An Integrative Review and Agenda for Future Research
Authors: Petelczyc Claire Aislinn , Capezio Alessandra , Wang Lu , Restubog Simon Lloyd D. , Aquino Karl
Published: September 2017

Play has gained increasing interest among progressive-minded managers as an important driver of motivation and productivity in work contexts. Despite its popularity in contemporary organizations, there is little consensus in the academic literature about the role of play in the workplace. This review organizes and synthesizes the current state of knowledge of play at work in order to gain a more comprehensive understanding of what play at work is, when individuals engage in play at work, and the effects of workplace play on work outcomes. First, we review existing definitions of play and their limitations. We then introduce a recent conceptualization of play in adulthood that defines play based on three core features and discuss its relevance in the workplace. Second, we review theoretical perspectives on play and extant empirical research on the antecedents and consequences of play at work, organizing it according to three levels of analysis. Third, we propose a promising agenda for future research by focusing on a number of important issues that have emerged from our review of existing work. These issues are organized into two sections: refining and extending the current research on play, and generating novel ideas and new research directions on unexplored areas of inquiry. We believe this review makes important and timely contributions to the research on play at work by providing comprehensive analysis of the diverse and fragmented literature on play in the workplace.
Increasing Daily Living Independence Using Video Activity Schedules in Middle School Students With Intellectual Disability
Authors: Shepley Sally B. , Spriggs Amy D. , Samudre Mark , Elliot Mary
Published: September 2017

This study used a multiple probe across participants design to (a) evaluate the use of system of least prompts to teach students to self-instruct and (b) evaluate the use of a mobile device for a video activity schedule of a functional daily living skill. In baseline, the classroom teacher asked participants to make a snack and collected performance data. In the technology training condition, the teacher implemented a system of least prompts procedure to teach participants to initiate use of the mobile device, navigate to a training video activity schedule, pause/play videos of training tasks, and perform the modeled training tasks. After meeting criterion in technology training, the classroom teacher evaluated participant performance making a snack following use of a mobile device to self-instruct using a video activity schedule. Participant technology use was still assessed but not included in criterion. All four participants learned to independently initiate and navigate the mobile device during technology training. Three participants self-instructed using the video activity schedule to independently make a snack.
Length, but Not Reactive Edges, of Cup-stack MWCNT Is Responsible for Toxicity and Acute Lung Inflammation
Authors: Hamilton Raymond F. , Tsuruoka Shuji , Wu Nianqiang , Wolfarth Michael , Porter Dale W , Bunderson-Schelvan Melisa , Holian Andrij
Published: September 2017

Multiwalled carbon nanotube (MWCNT) toxicity after inhalation has been associated with size, aspect ratio, rigidity, surface modification, and reactive oxygen species production. In this study, we investigated a series of cup-stacked MWCNT prepared as variants of the Creos 24PS. Mechanical chopping produced a short version (AR10) and graphitization to remove active reaction sites by extreme heat (2,800°C; Creos 24HT) to test the contribution of length and alteration of potential reaction sites to toxicity. The 3 MWCNT variants were tested in vitro in a human macrophage–like cell model and with C57BL/6 alveolar macrophages for dose-dependent toxicity and NLRP3 inflammasome activation. The 24PS and 24HT variants showed significant dose-dependent toxicity and inflammasome activation. In contrast, the AR10 variant showed no toxicity or bioactivity at any concentration tested. The in vivo results reflected those observed in vitro, with the 24PS and 24HT variants resulting in acute inflammation, including elevated polymorphonuclear counts, Interleukin (IL)-18, cathepsin B, and lactate dehydrogenase in isolated lung lavage fluid from mice exposed to 40 µg MWCNT. Taken together, these data indicate that length, but not the absence of proposed reaction sites, on the MWCNT influences particle bioactivity.