bluuebunny/crossref_metadata_2025 huggingface dataset:
Immune Response in Pneumocystis Infections According to the Host Immune System Status
Authors: Charpentier Eléna , Ménard Sandie , Marques Catherine , Berry Antoine , Iriart Xavier
Published: August 2021

The host immune response is critical in Pneumocystis pneumonia (PCP). Immunocompetent hosts can eliminate the fungus without symptoms, while immunodeficient hosts develop PCP with an unsuitable excessive inflammatory response leading to lung damage. From studies based on rodent models or clinical studies, this review aimed to better understand the pathophysiology of Pneumocystis infection by analysing the role of immune cells, mostly lymphocytes, according to the immune status of the infected host. Hence, this review first describes the immune physiological response in infected immunocompetent hosts that are able to eliminate the fungus. The objective of the second part is to identify the immune elements required for the control of the fungus, focusing on specific immune deficiencies. Finally, the third part concentrates on the effect of the different immune elements in immunocompromised subjects during PCP, to better understand which cells are detrimental, and which, on the contrary, are beneficial once the disease has started. This work highlights that the immune response associated with a favourable outcome of the infection may differ according to the immune status of the host. In the case of immunocompetency, a close communication between B cells and TCD4 within tertiary lymphocyte structures appears critical to activate M2 macrophages without much inflammation. Conversely, in the case of immunodeficiency, a pro-inflammatory response including Th1 CD4, cytotoxic CD8, NK cells, and IFNγ release seems beneficial for M1 macrophage activation, despite the impact of inflammation on lung tissue.
The Evolution of the Interactive Relationship between Urbanization and Land-Use Transition: A Case Study of the Yangtze River Delta
Authors: Niu Bo , Ge Dazhuan , Yan Rui , Ma Yingyi , Sun Dongqi , Lu Mengqiu , Lu Yuqi
Published: August 2021

In recent years, the impact of land-use systems on global climate change has become increasingly significant, and land-use change has become a hot issue of concern to academics, both within China and abroad. Urbanization, as an important socioeconomic factor, plays a vital role in promoting land-use transition, which also shows a significant spatial dependence on urbanization. This paper constructs a theoretical framework for the interaction relationship between urbanization and land-use transition, taking the Yangtze River Delta as an example, and measures the level of urbanization from the perspective of population urbanization, economic urbanization and social urbanization, while also evaluating the level of land-use morphologies from the perspective of dominant and recessive morphologies of land-use. We construct a PVAR model and coupled coordination model based on the calculated indexes for empirical analysis. The results show that the relationship between urbanization and land-use transition is not a simple linear relationship, but tends to be complex with the process of urbanization, and reasonable urbanization and land-use morphologies will promote further benign coupling in the system. By analyzing the interaction relationship between urbanization and land-use transition, this study enriches the study of land-use change and provides new pathways for thinking about how to promote high-quality urbanization.
Expert-Based Maps as a Regional Planning Tool Supporting Nature Conservation and Production-Integrated Compensation—A German Case Study on Biodiversity Offsets
Authors: Sponagel Christian , Raichle Andre , Maier Martin , Zhuber-Okrog Susanne , Greifenhagen-Kauffmann Ulrike , Angenendt Elisabeth , Bahrs Enno
Published: August 2021

Many countries worldwide have developed guidelines for offsetting impacts on nature and landscape. Suitable locations are the prerequisite for the implementation of these measures, and this might lead to conflicts with agriculture. In addition, comprehensive planning is often lacking and potential added values for nature conservation are not exploited. Concepts such as the so-called production-integrated compensation (PIC) have been introduced to give farmers the opportunity to actively participate in the offsetting process and improve cooperation. However, up to now, PIC has only rarely been put into practice. Against this backdrop, we have developed a regional planning tool for the implementation of PIC in practice. Based on geodata such as soil data, agricultural structure, or natural conditions at the field and landscape level, the general suitability, and specific measure-based recommendations for each plot can be verified with the help of a decision support system. These factors are assessed from both a nature and an agricultural perspective. The goal here is to highlight synergy effects and increase the likelihood of the proposed measures being implemented. Our tool facilitates the integrated planning of biodiversity offsets at regional level. In this way, it can promote the bundling and networking of measures. However, on-site analyses should be undertaken to complement the implementation of measures.
Land Use Transitions under Rapid Urbanization in Chengdu-Chongqing Region: A Perspective of Coupling Water and Land Resources
Authors: Pan Yuchen , Ma Li , Tang Hong , Wu Yiwen , Yang Zhongjian
Published: August 2021

Land resources and water resources are the important material basis of economic and social development, and their pattern determines the pattern of development. Based on the panel data of the Chengdu–Chongqing Economic Circle from 2011 to 2018, this paper evaluates the matching degree of water and land resources, and their respective matching degrees with the economic development in the Chengdu–Chongqing Economic Circle with the Gini coefficient method. Based on the two-way fixed effect model, an extended Cobb–Douglas production function model is established to analyze the sensitivity of economic growth to land and water factors. In addition, the restriction degree of water and land resources to the economic development of the Chengdu–Chongqing Economic Circle is measured quantitatively by using the growth damping coefficient. The results show that the water and land resources and economic development of the Chengdu–Chongqing Economic Circle have a high matching degree, but the inner cities have a great difference. The contribution of water resources to economic growth is greater than that of land resources. Both of them have a little growth drag, which shows that industrial development has disposed of the dependence of water and land resources. The development of the Chengdu–Chongqing Economic Circle needs to play the role of technological progress in promoting economic growth, and at the same time optimize the use of water and land resources to reduce its constraints on the economic growth. Finally, the policy suggestions of matching water and land resources and economic growth in different regions are put forward.
Sports, Transgender Rights and the Bodily Politics of Cisgender Supremacy
Authors: Sharrow Elizabeth A.
Published: August 2021

Between 2020 and 2021, one hundred and ten bills in state legislatures across the United States suggested banning the participation of transgender athletes on sports teams for girls and women. As of July 2021, ten such bills have become state law. This paper tracks the political shift towards targeting transgender athletes. Conservative political interests now seek laws that suture biological determinist arguments to civil rights of bodies. Although narrow binary definitions of sex have long operated in the background as a means for policy implementation under Title IX, Republican lawmakers now aim to reframe sex non-discrimination policies as means of gendered exclusion. The content of proposals reveal the centrality of ideas about bodily immutability, and body politics more generally, in shaping the future of American gender politics. My analysis of bills from 2021 argues that legislative proposals advance a logic of “cisgender supremacy” inhering in political claims about normatively gendered bodies. Political institutions are another site for advancing, enshrining, and normalizing cis-supremacist gender orders, explicitly joining cause with medical authorities as arbiters of gender normativity. Characteristics of bodies and their alleged role in evidencing sex itself have fueled the tactics of anti-transgender activists on the political Right. However, the target of their aims is not mere policy change but a state-sanctioned return to a narrowly cis- and heteropatriarchal gender order.
Experimental Approaches for Testing the Hypothesis of the Emergence of Life at Submarine Alkaline Vents
Authors: Altair Thiago , Borges Luiz G. F. , Galante Douglas , Varela Hamilton
Published: August 2021

Since the pioneering experimental work performed by Urey and Miller around 70 years ago, several experimental works have been developed for approaching the question of the origin of life based on very few well-constructed hypotheses. In recent years, attention has been drawn to the so-called alkaline hydrothermal vents model (AHV model) for the emergence of life. Since the first works, perspectives from complexity sciences, bioenergetics and thermodynamics have been incorporated into the model. Consequently, a high number of experimental works from the model using several tools have been developed. In this review, we present the key concepts that provide a background for the AHV model and then analyze the experimental approaches that were motivated by it. Experimental tools based on hydrothermal reactors, microfluidics and chemical gardens were used for simulating the environments of early AHVs on the Hadean Earth (~4.0 Ga). In addition, it is noteworthy that several works used techniques from electrochemistry to investigate phenomena in the vent–ocean interface for early AHVs. Their results provided important parameters and details that are used for the evaluation of the plausibility of the AHV model, and for the enhancement of it.
A Role for Superficial Heat Therapy in the Management of Non-Specific, Mild-to-Moderate Low Back Pain in Current Clinical Practice: A Narrative Review
Authors: Freiwald Jürgen , Magni Alberto , Fanlo-Mazas Pablo , Paulino Ema , Sequeira de Medeiros Luís , Moretti Biagio , Schleip Robert , Solarino Giuseppe
Published: August 2021

Low back pain (LBP) is a leading cause of disability. It significantly impacts the patient’s quality of life, limits their daily living activities, and reduces their work productivity. To reduce the burden of LBP, several pharmacological and non-pharmacological treatment options are available. This review summarizes the role of superficial heat therapy in the management of non-specific mild-to-moderate LBP. First, we outline the common causes of LBP, then discuss the general mechanisms of heat therapy on (LBP), and finally review the published evidence regarding the impact of superficial heat therapy in patients with acute or chronic non-specific LBP. This review demonstrates that continuous, low-level heat therapy provides pain relief, improves muscular strength, and increases flexibility. Therefore, this effective, safe, easy-to-use, and cost-effective non-pharmacological pain relief option is relevant for the management of non-specific mild or moderate low back pain in current clinical practice.
Water Jet Technology: Experimental Verification of the Input Factors Variation Influence on the Generated Vibration Levels and Frequency Spectra
Authors: Olejarova Stefania , Krenicky Tibor
Published: August 2021

Vibration measurement belongs amongst the most important activities for the correct and stable operation of machines in terms of quality, economy, and safety. Monitoring the condition of the machine provides the key data for the detection of machine parts damage, thus preventing unexpected failure states and production drop-outs. Therefore, special attention is paid in the paper to the measurement and evaluation of basic parameters of vibration, particularly the frequency of vibrations and the amplitude of vibration acceleration. Experimental measurements were performed while machining the material HARDOX 500/10 on a production system using the abrasive water jet technology (AWJ) with the varied abrasive mass flow and the feed rate. By evaluating the results of measurements, recommendations of suitable and inappropriate combinations of operating parameters were formulated, widening current knowledge in the field of the abrasive parameters and the speed of movement of the technological head influence the amplitudes of vibration acceleration in the operation of production systems with AWJ technology.
Effect of Structural Differences on the Mechanical Properties of 3D Integrated Woven Spacer Sandwich Composites
Authors: Zhu Lvtao , Rahman Mahfuz Bin , Wang Zhenxing
Published: August 2021

Three-dimensional integrated woven spacer sandwich composites have been widely used as industrial textiles for many applications due to their superior physical and mechanical properties. In this research, 3D integrated woven spacer sandwich composites of five different specifications were produced, and the mechanical properties and performance were investigated under different load conditions. XR-CT (X-ray computed tomography) images were employed to visualize the microstructural details and analyze the fracture morphologies of fractured specimens under different load conditions. In addition, the effects of warp and weft direction, face sheet thickness, and core pile height on the mechanical properties and performance of the composite materials were analyzed. This investigation can provide significant guidance to help determine the structure of composite materials and design new products according to the required mechanical properties.
A Comprehensive Study on the Hardening Features and Performance of Self-Compacting Concrete with High-Volume Fly Ash and Slag
Authors: Yang Zhenghong , Liu Sijia , Yu Long , Xu Linglin
Published: August 2021

The main concern of this work is to evaluate the influences of supplementary cementitious materials (fly ash, slag) and a new type of polycarboxylate superplasticizer containing viscosity modifying agents (PCE-VMA) on the performance of self-compacting concrete (SCC). The workability, hydration process, mechanical property, chloride permeability, degree of hydration and pore structure of SCC were investigated. Results indicate that the addition of fly ash and slag slows down early hydration and decreases the hydration degree of SCC, and thus leads to a decline in compressive strengths, especially within the first 7 days. The addition of slag refines pore structure and contributes to lower porosity, and thus the chloride permeability of SCC is decreased during the late hydration stage. Additionally, a new factor of calculated water–binder ratio is put forward, which can directly reflect the free water content of concrete mixture after mixing, and guide the mix proportion design of SCC.
Unprecedented Use of NHC Gold (I) Complexes as Catalysts for the Selective Oxidation of Ethane to Acetic Acid
Authors: Ribeiro Ana P. C. , Matias Inês A. S. , Zargaran Poorya , Hashmi A. Stephen K. , Martins Luísa M. D. R. S.
Published: August 2021

The highly efficient eco-friendly synthesis of acetic acid (40% yield) directly from ethane is achieved by the unprecedented use of N-heterocyclic carbene (NHC) and N-heterocyclic oxo-carbene (NHOC) gold(I) catalysts in mild conditions. This is a selective and promising protocol to generate directly acetic acid from ethane, in comparison with the two most used methods: (i) the three-step, capital- and energy-intensive process based on the high-temperature conversion of methane to acetic acid; (ii) the current industrial methanol carbonylation processes, based in iridium and expensive rhodium catalysts. Green metrics determinations highlight the environmental advantages of the new ethane oxidation procedure. Comparison with previous reported published catalysts is performed to highlight the features of this remarkable protocol.
Prospective Elementary Teachers’ Pedagogical Knowledge for Mathematical Problem Solving
Authors: Piñeiro Juan Luis , Chapman Olive , Castro-Rodríguez Elena , Castro Enrique
Published: August 2021

Research on mathematics teachers’ knowledge has generally focused more on mathematics concepts than mathematical processes. This paper addresses the latter with a focus on mathematical problem solving (PS). It reports on a study that investigated the pedagogical knowledge for PS of prospective elementary school teachers of mathematics (PTs). Participants were 149 PTs at a university in Spain. They were at the end of their teacher education program. Data sources consisted of a questionnaire on knowledge of learning PS and a questionnaire on knowledge of teaching PS. Findings indicated that the PTs held combination of different levels of knowledge of PS learning and teaching. Many of them demonstrated appropriate knowledge of many characteristics for (1) PS learning consisting of student as a problem-solver, PS as a worthwhile task, non-cognitive factor related to PS, and (2) PS teaching consisting of PS teaching approaches, discourse in PS, intervention during stuck state in PS, PS assessment, and PS resources. However, there were also contradictions and limitations to their knowledge with implications for teacher education. These combination of appropriate and inappropriate knowledge resulted in some conflicts that are related to teaching actions and would limit student’ learning of PS.
Methodology and Models for Individuals’ Creditworthiness Management Using Digital Footprint Data and Machine Learning Methods
Authors: Orlova Ekaterina V.
Published: August 2021

This research deals with the challenge of reducing banks’ credit risks associated with the insolvency of borrowing individuals. To solve this challenge, we propose a new approach, methodology and models for assessing individual creditworthiness, with additional data about borrowers’ digital footprints to implement comprehensive analysis and prediction of a borrower’s credit profile. We suggest a model for borrowers’ clustering based on the method of hierarchical clustering and the k-means method, which groups actual borrowers having similar creditworthiness and similar credit risks into homogeneous clusters. We also design the model for borrowers’ classification based on the stochastic gradient boosting (SGB) method, which reliably determines the cluster number and therefore the risk level for a new borrower. The developed models are the basis for decision making regarding the decision about lending value, interest rates and lending terms for each risk-homogeneous borrower’s group. The modified version of the methodology for assessing individual creditworthiness is presented, which is to reduce the credit risks and to increase the stability and profitability of financial organizations.
Lidocaine: A Local Anesthetic, Its Adverse Effects and Management
Authors: Bahar Entaz , Yoon Hyonok
Published: August 2021

The most widely used medications in dentistry are local anesthetics (LA), especially lidocaine, and the number of recorded adverse allergic responses, particularly of hazardous responses, is quite low. However, allergic reactions can range from moderate to life-threatening, requiring rapid diagnosis and treatment. This article serves as a review to provide information on LA, their adverse reactions, causes, and management.
Cage or Pelvic Graft—Study on Bony Fusion of the Ventral Thoracic and Lumbar Spine in Traumatic Vertebral Fractures
Authors: Jäckle Katharina , Brix Theresa , Oberthür Swantje , Roch Paul Jonathan , Sehmisch Stephan , Lehmann Wolfgang , Weiser Lukas
Published: August 2021

Background and Objectives: Stabilization of the spine by cage implantation or autologous pelvic bone graft are surgical methods for the treatment of traumatic spine fractures. These methods serve to stably re-adjust the spine and to prevent late detrimental effects such as pain or increasing kyphosis. They both involve ventral interventions using interbody fusion to replace the intervertebral disc space between the vertebral bodies either by cages or autologous pelvic bone grafts. We examined which of these methods serves the patients better in terms of bone fusion and the long-term clinical outcome. Materials and Methods: Forty-six patients with traumatic fractures (12 cages; mean age: 54.08/34 pelvic bone grafts; mean age: 42.18) who received an anterior fusion in the thoracic or lumbar spine were included in the study. Postoperative X-ray images were evaluated, and fusion of the stabilized segment was inspected by two experienced spine surgeons. The time to discharge from hospital and gender differences were evaluated. Results: There was a significant difference of the bone fusion rate of patients with autologous pelvic bone grafts in favor of cage implantation (p = 0.0216). Also, the stationary phase of patients who received cage implantations was clearly shorter (17.50 days vs. 23.85 days; p = 0.0089). In addition, we observed a significant gender difference with respect to the bony fusion rate in favor of females treated with cage implantations (p < 0.0001). Conclusions: Cage implantations after spinal fractures result in better bony fusion rates as compared to autologous pelvic bone grafts and a shorter stay of the patients in the hospital. Thus, we conclude that cage implantations rather than autologous pelvic bone grafts should be the preferred surgical treatment for stabilizing the spine after fracture.
Are We Paving the Way to Dig Out of the “Pandemic Hole”? A Narrative Review on SARS-CoV-2 Vaccination: From Animal Models to Human Immunization
Authors: Tardiolo Giuseppe , Brianti Pina , Sapienza Daniela , dell’Utri Pia , Dio Viviane Di , Rao Giuseppe , Calabrò Rocco Salvatore
Published: August 2021

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new pathogen agent causing the coronavirus infectious disease (COVID-19). This novel virus originated the most challenging pandemic in this century, causing economic and social upheaval internationally. The extreme infectiousness and high mortality rates incentivized the development of vaccines to control this pandemic to prevent further morbidity and mortality. This international scenario led academic scientists, industries, and governments to work and collaborate strongly to make a portfolio of vaccines available at an unprecedented pace. Indeed, the robust collaboration between public systems and private companies led to resolutive actions for accelerating therapeutic interventions and vaccines mechanism. These strategies contributed to rapidly identifying safe and effective vaccines as quickly and efficiently as possible. Preclinical research employed animal models to develop vaccines that induce protective and long-lived immune responses. A spectrum of vaccines is worldwide under investigation in various preclinical and clinical studies to develop both individual protection and safe development of population-level herd immunity. Companies employed and developed different technological approaches for vaccines production, including inactivated vaccines, live-attenuated, non-replicating viral vector vaccines, as well as acid nucleic-based vaccines. In this view, the present narrative review provides an overview of current vaccination strategies, taking into account both preclinical studies and clinical trials in humans. Furthermore, to better understand immunization, animal models on SARS-CoV-2 pathogenesis are also briefly discussed.
Assessment of an Integrated and Sustainable Multistage System for the Treatment of Poultry Slaughterhouse Wastewater
Authors: Dyosile Phumeza Akhona , Mdladla Cebisa , Njoya Mahomet , Basitere Moses , Ntwampe Seteno Karabo Obed , Kaskote Ephraim
Published: August 2021

This paper assesses the performance of an integrated multistage laboratory-scale plant, for the treatment of poultry slaughterhouse wastewater (PSW). The system was comprised of an eco-flush dosed bio-physico pre-treatment unit for fats, oil, and grease (FOG) hydrolysis prior to the PSW being fed to a down-flow expanded granular bed reactor (DEGBR), coupled to a membrane bioreactor (DEGBR-MBR). The system’s configuration strategy was developed to achieve optimal PSW treatment by introducing the enzymatic pre-treatment unit for the lipid-rich influent (PSW) in order to treat FOG including odour causing constituents such as H2S known to sour anaerobic digestion (AD) such that the PSW pollutant load is alleviated prior to AD treatment. This was conducted to aid the reduction in clogging and sludge washout in the DEGBR-MBR systems and to achieve the optimum reactor and membrane system performance. A performance for the treatment of PSW after lipid reduction was conducted through a qualitative analysis by assessing the pre- and post-pre-treatment units’ chemical oxygen demand (COD), total suspended solids (TSS), and FOG concentrations across all other units and, in particular, the membrane units. Furthermore, a similar set-up and operating conditions in a comparative study was also performed. The pre-treatment unit’s biodelipidation abilities were characterised by a mean FOG removal of 80% and the TSS and COD removal reached 38 and 56%, respectively. The final acquired removal results on the DEGBR, at an OLR of ~18–45 g COD/L.d, was 87, 93, and 90% for COD, TSS, and FOG, respectively. The total removal efficiency across the pre-treatment-DEGBR-MBR units was 99% for COD, TSS, and FOG. Even at a high OLR, the pre-treatment-DEGBR-MBR train seemed a robust treatment strategy and achieved the effluent quality set requirements for effluent discharge in most countries.
Physical and Mechanical Properties of Hollow Fiber Membranes and Technological Parameters of the Gas Separation Process
Authors: Kagramanov Georgy , Gurkin Vladimir , Farnosova Elena
Published: August 2021

The porous layer of composite and asymmetric hollow fiber membranes acts as a support and is exposed to strong mechanical stresses. The effect of external pressure on the polymer structure and, as a consequence, the separation characteristics of the membrane remains unsolved. Based on the solution of the Lamé approach to the calculation of the stress state of a hollow cylinder, a method of calculation was proposed for hollow fiber membranes. Calculations were based on the approximation of the isotropic nature of the physical and mechanical characteristics of the selective layer and substrate. Permissible deformation of the membrane’s selective layer was determined from the linear sector of strain-on-stress dependence, where Hooke’s law was performed. For these calculations, commercial polyethersulfone membranes were chosen with an inner and/or outer selective layer and with the following values of Young’s modulus of 2650 and 72 MPa for the selective and porous layers, respectively. The results obtained indicate that the dependence of the maximum allowable operating pressure on the substrate thickness asymptotically trends to a certain maximum value for a given membrane. Presented data showed that membranes with outer selective layer can be operated at higher working pressure. Optimal parameters for hollow fiber gas separation membrane systems should be realized, solving the optimization problem and taking into account the influence of operating, physicochemical and physicomechanical parameters on each other.
Study on the Influence of Geometric Characteristics of Grain Membranes on Permeability Properties in Porous Sandstone
Authors: Shi Run , Xiao Huaiguang , Shao Chengmeng , Huang Mingzheng , He Lei
Published: August 2021

Studying the influence of grain characteristics on fluid flow in complex porous rock is one of the most important premises to reveal the permeability mechanism. Previous studies have mainly investigated the fluid flow laws in complex rock structures using an uncontrollable one single parameter of natural rock models or oversimplified control group models. In order to solve these problems, this paper proposes a novel method to reconstruct models that can independently control one single parameter of rock grain membranes based on mapping and reverse-mapping ideas. The lattice Boltzmann method is used to analyze the influence of grain parameters (grain radius, space, roundness, orientation, and model resolution) on the permeability characteristics (porosity, connectivity, permeability, flow path, and flow velocity). Results show that the grain radius and space have highly positive and negative correlations with permeability properties. The effect of grain roundness and resolution on permeability properties shows a strong regularity, while grain orientation on permeability properties shows strong randomness. This study is of great significance to reveal the fluid flow laws of natural rock structures.
Experimental Study on Melt Decontamination of Stainless Steel and Carbon Steel Using Induction Melting
Authors: Zhao Pengfei , Chung Wonsub , Lee Mincheol , Ahn Seokyoung
Published: August 2021

Many nuclear power plants (NPP) facilities have aged and are being dismantled around the world. As a result, large amounts of radioactive metal waste are generated during decommissioning. Carbon steel, stainless steel, and Inconel are the most common metals used in NPP, and radioactive contaminants are mostly accumulated in the corrosion layer. There are various radionuclides, but the main ones are 60Co, 137Cs, 54Mn and 51Cr. 60Co is the major activated corrosion product and responsible for high gamma radiation and longer half-life (5.27 years.) also makes it the most difficult to remove. Therefore, we investigated the melt decontamination characteristics of 60Co by introducing various slags using induction melting for stainless steel and carbon steel. Cobalt plating and cobalt oxide film coatings were used as specimens instead for safety purposes. The amount of cobalt removed from the slag was analyzed by using XRF. About 11% of the cobalt was removed from the contaminated metal due to slag oxide formation. The distribution of cobalt in the melted metal was also almost homogeneous according to the XRD analysis.
Enhanced Permeability of Fe-Based Amorphous Powder Cores Realized through Selective Incorporation of Carbonyl Iron Powders at Inter-Particle Voids
Authors: Kim Hea-Ran , Jang Min-Sun , Nam Yeong-Gyun , Kim Yun-Seok , Yang Sang-Sun , Kim Yong-Jin , Jeong Jae-Won
Published: August 2021

In this study, we demonstrate a hybrid multimodal soft magnetic composite (SMC) comprising gas-atomized spherical amorphous powder (AP) and carbonyl-iron powder (CIP), and present its enhanced electromagnetic properties. CIP is selectively incorporated into voids between AP, and deforms during compression, effectively reducing the pores, resulting in high packing density of the core, where CIP magnetically bridges AP and helps magnetic domain rotation much efficiently. The hybrid SMC with the addition of 20 wt.% CIP showed constant effective permeability of 57 up to 1 MHz, a remarkable 63% increase compared with the AP core, while DC bias superimposing retention level of 61% was secured with the help of high magnetization of CIP. In addition, the effect of SiO2 surface insulation, prepared by the sol-gel process, on the high-frequency magnetic properties of hybrid SMCs, was also evaluated. It is thus revealed that the high-frequency dynamic loss of the hybrid core, originating from intra-particle eddy current loss and anomalous loss component, and inter-particle eddy currents are negligibly small. We believe that our approach using AP/CIP multimodal hybrid SMCs is an effective way of achieving high permeability as well as high DC bias characteristics at high frequencies. This process will be highly beneficial for the miniaturization of power inductors.
Effect of Process Parameters on the Quality of Laser-Cut Stainless Steel Thin Plates
Authors: Buj-Corral Irene , Costa-Herrero Lluís , Domínguez-Fernández Alejandro
Published: August 2021

At present, laser cutting is currently employed to cut metallic plates, due to their good finish and dimensional quality, as well as because of the flexibility of the process to obtain different shapes. In the present paper, surface roughness, dimensional accuracy, and burr thickness of thin plates of 0.8 mm are studied as functions of different process parameters: pulse frequency, pulse width, and speed. Eight different experiments were performed according to a full 23 factorial design, with two replicates each. Square specimens of 10 mm × 10 mm were cut. Arithmetical mean roughness Ra was measured with a contact roughness meter, and the dimensions and burr thickness with a micrometer. Ra values ranged between 1.89 and 3.86 µm, dimensional error values between 0.22 and 0.93%, and burr thickness between 2 and 34 µm. Regression analysis was performed, and linear models were obtained for each response. Results showed that roughness depends mainly on frequency, on the interaction of frequency and pulse width and on pulse width. Dimensional error depends on pulse width, frequency, and the interaction between pulse width and speed. Burr thickness is influenced by frequency, pulse width, and the interaction between frequency and speed. Multi-objective optimization showed that, in order to simultaneously minimize the three responses, it is recommended to use high frequency (80 Hz), high pulse width (0.6 ms), and high speed (140 mm/min). The present study will help to select appropriate laser cutting conditions in thin plates, in order to favor good surface finish and dimensional accuracy, as well as low burr thickness.
X-ray Radiography Inspection of Pores of Thin Aluminum Foam during Press Forming Immediately after Foaming
Authors: Hangai Yoshihiko , Kawato Daisuke , Ohashi Masataka , Ando Mizuki , Ogura Takuya , Morisada Yoshiaki , Fujii Hidetoshi , Kamakoshi Yuichiroh , Mitsugi Hironao , Amagai Kenji
Published: August 2021

Forming aluminum foam to the desired shape while retaining its pore structures is essential for manufacturing aluminum foam products. Recently, a press forming process for aluminum foam that is performed after precursor foaming but before solidification has been proposed. In this study, to track individual pores throughout press forming immediately after foaming, X-ray radiography inspection was applied. A thin precursor was used, and foaming was constrained to the X-ray transmission direction. It was shown that, although some pores coalesced with other pores, the pores did not collapse during press forming. In addition, the porosity of aluminum foam evaluated from X-ray transmission images was constant during press forming. Some pores retained their shape during press forming but their position was changed by the material flow generated by press forming. These results show that by press forming before the solidification of aluminum foam, aluminum foam can be shaped without the collapse of pores.
Respiratory Colonization and Short-Term Temporal Changes in the Urinary Metabolome of Children
Authors: Ambroggio Lilliam , Florin Todd A. , Williamson Kayla , Pfefferman Cory , Wagner Brandie D. , Yeomans Larisa , Kim Jae Hyun , Sucharew Heidi , Macaluso Maurizio , Ruddy Richard M. , Shah Samir S. , Stringer Kathleen A.
Published: August 2021

The human metabolome may vary based on age, over time, and in the presence of viral carriage and bacterial colonization—a common scenario in children. We used nuclear magnetic resonance spectroscopy to identify and quantify urinary metabolites of children without signs or symptoms of respiratory illness. A urine sample and two nasopharyngeal swabs were collected to test for respiratory viral pathogens and colonization by Streptococcus pneumoniae (Sp). Urine samples were collected at the initial visit, 24 h post-enrollment, and 10–14 days post-enrollment. Of the 122 children enrolled, 24% had a virus detected and 19.7% had Sp detected. Intraclass correlation coefficients demonstrated greater within-subject versus between-subject variability for all metabolites detected. In linear mixed models adjusted for age, time, history of asthma, Sp, and viruses, 1-methylnicotinamide was increased by 50% in children with Sp and decreased by 35% in children with rhinovirus/enterovirus. Children with Sp had 83% higher levels of trimethylamine-N-oxide compared with those without Sp. However, when adjusting for multiple comparisons, the association was no longer statistically significant. In conclusion, there appear to be short-term changes within the urinary metabolome of healthy children, but levels of metabolites did not statistically differ in children with viral carriage or Sp detected.
Loop-Mediated Isothermal Amplification in a Core-Shell Bead Assay for the Detection of Tyrosine Kinase AXL Overexpression
Authors: Sreejith Kamalalayam Rajan , Umer Muhammad , Singha Pradip , Nguyen Nhat-Khuong , Kasetsirikul Surasak , Ooi Chin Hong , Shiddiky Muhammad J. A. , Nguyen Nam-Trung
Published: August 2021

The upregulated expression of tyrosine kinase AXL has been reported in several hematologic and solid human tumors, including gastric, breast, colorectal, prostate and ovarian cancers. Thus, AXL can potentially serve as a diagnostic and prognostic biomarker for various cancers. This paper reports the first ever loop-mediated isothermal amplification (LAMP) in a core-shell bead assay for the detection of AXL gene overexpression. We demonstrated simple instrumentation toward a point-of-care device to perform LAMP. This paper also reports the first ever use of core-shell beads as a microreactor to perform LAMP as an attempt to promote environmentally-friendly laboratory practices.
PI Film Laser Micro-Cutting for Quantitative Manufacturing of Contact Spacer in Flexible Tactile Sensor
Authors: Wu Congyi , Zhang Tian , Huang Yu , Rong Youmin
Published: August 2021

The contact spacer is the core component of flexible tactile sensors, and the performance of this sensor can be adjusted by adjusting contact spacer micro-hole size. At present, the contact spacer was mainly prepared by non-quantifiable processing technology (electrospinning, etc.), which directly leads to unstable performance of tactile sensors. In this paper, ultrathin polyimide (PI) contact spacer was fabricated using nanosecond ultraviolet (UV) laser. The quality evaluation system of laser micro-cutting was established based on roundness, diameter and heat affected zone (HAZ) of the micro-hole. Taking a three factors, five levels orthogonal experiment, the optimum laser cutting process was obtained (pulse repetition frequency 190 kHz, cutting speed 40 mm/s, and RNC 3). With the optimal process parameters, the minimum diameter was 24.3 ± 2.3 μm, and the minimum HAZ was 1.8 ± 1.1 μm. By analyzing the interaction process between nanosecond UV laser and PI film, the heating-carbonization mechanism was determined, and the influence of process parameters on the quality of micro-hole was discussed in detail in combination with this mechanism. It provides a new approach for the quantitative industrial fabrication of contact spacers in tactile sensors.
Broadband Solar Absorber Based on Square Ring cross Arrays of ZnS
Authors: Xu Feng , Lin Lixia , Fang Jun , Huang Mianli , Wang Feng , Su Jianzhi , Li Shufen , Pan Miao
Published: August 2021

Solar energy is an inexhaustible clean energy. However, how to improve the absorption efficiency in the visible band is a long-term problem for researchers. Therefore, an electromagnetic wave absorber with an ultra-long absorption spectrum has been widely considered by researchers of optoelectronic materials. A kind of absorbing material based on ZnS material is presented in this paper. Our purpose is for the absorber to achieve a good and wide spectrum of visible light absorption performance. In the wide spectrum band (553.0 THz–793.0 THz) of the absorption spectrum, the average absorption rate of the absorber is above 94%. Using surface plasmon resonance (SPR) and gap surface plasmon mode, the metamaterial absorber was studied in visible light. In particular, the absorber is insensitive to both electric and magnetic absorption. The absorber can operate in complex electromagnetic environments and at high temperatures. This is because the absorber is made of refractory metals. Finally, we discuss and analyze the influence of the parameters regulating the absorber on the absorber absorption efficiency. We have tried to explain why the absorber can produce wideband absorption.
Sensing Circuit Design Techniques for RRAM in Advanced CMOS Technology Nodes
Authors: Zhang Donglin , Peng Bo , Zhao Yulin , Han Zhongze , Hu Qiao , Liu Xuanzhi , Han Yongkang , Yang Honghu , Cheng Jinhui , Ding Qingting , Jiang Haijun , Yang Jianguo , Lv Hangbing
Published: August 2021

Resistive random access memory (RRAM) is one of the most promising new nonvolatile memories because of its excellent properties. Moreover, due to fast read speed and low work voltage, it is suitable for seldom-write frequent-read applications. However, as technology nodes shrink, RRAM faces many issues, which can significantly degrade RRAM performance. Therefore, it is necessary to optimize the sensing schemes to improve the application range of RRAM. In this paper, the issues faced by RRAM in advanced technology nodes are summarized. Then, the advantages and weaknesses in the novel design and optimization methodologies of sensing schemes are introduced in detail from three aspects, the reference schemes, sensing amplifier schemes, and bit line (BL)-enhancing schemes, according to the development of technology in especially recent years, which can be the reference for designing the sensing schemes. Moreover, the waveforms and results of each method are illustrated to make the design easy to understand. With the development of technology, the sensing schemes of RRAM become higher speed and resolution, low power consumption, and are applied at advanced technology nodes and low working voltage. Now, the most advanced nodes the RRAM applied is 14 nm node, the lowest working voltage can reach 0.32 V, and the shortest access time can be only a few nanoseconds.
Genetic Responses of Metabolically Active Limnospira indica Strain PCC 8005 Exposed to γ-Radiation during Its Lifecycle
Authors: Yadav Anu , Maertens Laurens , Meese Tim , Van Nieuwerburgh Filip , Mysara Mohamed , Leys Natalie , Cuypers Ann , Janssen Paul Jaak
Published: August 2021

Two morphotypes of the cyanobacterial Limnospira indica (formerly Arthrospira sp.) strain PCC 8005, denoted as P2 (straight trichomes) and P6 (helical trichomes), were subjected to chronic gamma radiation from spent nuclear fuel (SNF) rods at a dose rate of ca. 80 Gy·h−1 for one mass doubling period (approximately 3 days) under continuous light with photoautotrophic metabolism fully active. Samples were taken for post-irradiation growth recovery and RNA-Seq transcriptional analysis at time intervals of 15, 40, and 71.5 h corresponding to cumulative doses of ca. 1450, 3200, and 5700 Gy, respectively. Both morphotypes, which were previously reported by us to display different antioxidant capacities and differ at the genomic level in 168 SNPs, 48 indels and 4 large insertions, recovered equally well from 1450 and 3200 Gy. However, while the P2 straight type recovered from 5700 Gy by regaining normal growth within 6 days, the P6 helical type took about 13 days to recover from this dose, indicating differences in their radiation tolerance and response. To investigate these differences, P2 and P6 cells exposed to the intermediate dose of gamma radiation (3200 Gy) were analyzed for differential gene expression by RNA-Seq analysis. Prior to batch normalization, a total of 1553 genes (887 and 666 of P2 and P6, respectively, with 352 genes in common) were selected based on a two-fold change in expression and a false discovery rate FDR smaller or equal to 0.05. About 85% of these 1553 genes encoded products of yet unknown function. Of the 229 remaining genes, 171 had a defined function while 58 genes were transcribed into non-coding RNA including 21 tRNAs (all downregulated). Batch normalization resulted in 660 differentially expressed genes with 98 having a function and 32 encoding RNA. From PCC 8005-P2 and PCC 8005-P6 expression patterns, it emerges that although the cellular routes used by the two substrains to cope with ionizing radiation do overlap to a large extent, both strains displayed a distinct preference of priorities.
Sars-CoV-2 Virus Infection May Interfere CD34+ Hematopoietic Stem Cells and Megakaryocyte–Erythroid Progenitors Differentiation Contributing to Platelet Defection towards Insurgence of Thrombocytopenia and Thrombophilia
Authors: Balzanelli Mario Giosuè , Distratis Pietro , Dipalma Gianna , Vimercati Luigi , Inchingolo Alessio Danilo , Lazzaro Rita , Aityan Sergey Khachatur , Maggiore Maria Elena , Mancini Antonio , Laforgia Rita , Pezzolla Angela , Tomassone Diego , Pham Van Hung , Iacobone Donatello , Castrignano Annalisa , Scarano Antonio , Lorusso Felice , Tafuri Silvio , Migliore Giovanni , Inchingolo Angelo Michele , Nguyen Kieu Cao Diem , Toai Tran Cong , Inchingolo Francesco , Isacco Ciro Gargiulo
Published: August 2021

To date, several cases of thrombosis have been confirmed to be related to Sars-CoV-2 infection. Multiple attempts detected the prolonged occurrence of Sars-CoV-2 viral RNA (long COVID) in whole blood suggesting that virus byproducts may remain within cells and tissues well over the disease has finished. Patients may develop severe thrombocytopenia, acute anemia of inflammation and, systemic thrombosis with the fatal course of disease, which is suggestive of further interferences of Sars-CoV-2 on hematopoietic stem cells (HSCs) within the differentiation process towards erythroid and megakaryocytic cells. Therefore, we speculated whether Sars-CoV-2 propagates in or compartmentalizes with hematopoietic progenitor, erythroid, and megakaryocytic cells as the main cause of thrombotic events in either COVID-19 patients or vaccinated individuals. Results: The Sars-CoV-2 RNA replication, protein translation and infectious particle formation as the spike proteins in hematopoietic cell lines take place via the angiotensin-converting enzyme 2 (ACE2) entry pathway within primary CD34+ HSCs inducing, ex vivo, the formation of defected erythroid and megakaryocytic cells that eventually become targets of humoral and adaptive immune cells. Conclusions: Viral particles from affected CD34+ HSCs or the cellular component of RBC units and eventually platelets, present the greatest risk for sever thrombosis-transmitted Sars-CoV-2 infections.
Melting Process and Viscosity of Bohemian Historical Glasses Studied on Model Glasses
Authors: Pánová Karolína , Jílková Kristýna , Rohanová Dana , Lahodný František , Galusková Dagmar , Míka Martin
Published: August 2021

Analyzing the chemical composition of archaeological glasses can provide an insight into their provenance and raw materials used in their making. However, to the authors’ knowledge, the historical production process itself and melting characteristics of the glasses have not yet been extensively investigated. The main focus of this paper is to describe the melting process of three main types of Bohemian historical glasses: Gothic (14th–1st half of 16th c.); Renaissance (16th–17th c.); and Baroque (end of 17th–18th c.). The model glasses were prepared from natural raw materials and processes that take place during melting were investigated using optical microscopy, SEM-EDS, XRD, and DTA-TG methods. Furthermore, the viscosity of model glasses and thermal dilatation was measured and used to calculate the reference viscosity points. The results illustrate the complexity of historical glass melting, as well as the technological progress between different periods.