bluuebunny/crossref_metadata_2025 huggingface dataset:
Beneficial Use Impairments, Degradation of Aesthetics, and Human Health: A Review
Authors: Slawsky Erik D. , Hoffman Joel C. , Cowan Kristen N. , Rappazzo Kristen M.
Published: May 2022

In environmental programs and blue/green space development, improving aesthetics is a common goal. There is broad interest in understanding the relationship between ecologically sound environments that people find aesthetically pleasing and human health. However, to date, few studies have adequately assessed this relationship, and no summaries or reviews of this line of research exist. Therefore, we undertook a systematic literature review to determine the state of science and identify critical needs to advance the field. Keywords identified from both aesthetics and loss of habitat literature were searched in PubMed and Web of Science databases. After full text screening, 19 studies were included in the review. Most of these studies examined some measure of greenspace/bluespace, primarily proximity. Only one study investigated the impacts of making space quality changes on a health metric. The studies identified for this review continue to support links between green space and various metrics of health, with additional evidence for blue space benefits on health. No studies to date adequately address questions surrounding the beneficial use impairment degradation of aesthetics and how improving either environmental quality (remediation) or ecological health (restoration) efforts have impacted the health of those communities.
Characteristics of Train–Pedestrian Collisions in Southwest China, 2011–2020
Authors: Guo Zizheng , Chen Zhenqi , Zhang Jingyu , Guo Qiaofeng , He Chuanning , Zhao Yongliang
Published: May 2022

Although train–pedestrian collisions are the primary source of railway casualties, the characteristics of this phenomenon have not been fully investigated in China. This study examined such collisions in the Greater Sichuan-Chongqing area of China by conducting a thorough descriptive analysis of 2090 incident records from 2011 to 2020. The results showed that such collisions have declined gradually over the past decade, but the fatality rate remains high. We found that such collisions were more likely to happen to men, senior citizens and people crossing the tracks and that they occurred more frequently in the morning. While collision rates dropped in February, collisions were more likely to occur in December. In contrast to the situation in Western countries, weekends were not related to increased occurrence. The absence of a protective fence led to a higher collision rate, but level crossings are no longer a concern since most such structures in China have been rebuilt as overpasses. Mild slopes and extreme curvatures were also found to increase the occurrence of such collisions. Freight trains were most likely to be involved in train–pedestrian collisions, and collisions caused by high-speed trains were rare both absolutely and relatively. However, when collisions did occur, higher train speeds were linked with higher fatality rates. The findings suggest that patterns of train–pedestrian collisions in China differ from those in the Western world. This difference might be caused by differences in culture, geography, weather and railway development policies. Future research directions and possible preventive measures are also discussed.
Utilization of Random Forest and Deep Learning Neural Network for Predicting Factors Affecting Perceived Usability of a COVID-19 Contact Tracing Mobile Application in Thailand “ThaiChana”
Authors: Ong Ardvin Kester S. , Chuenyindee Thanatorn , Prasetyo Yogi Tri , Nadlifatin Reny , Persada Satria Fadil , Gumasing Ma. Janice J. , German Josephine D. , Robas Kirstien Paola E. , Young Michael N. , Sittiwatethanasiri Thaninrat
Published: May 2022

The continuous rise of the COVID-19 Omicron cases despite the vaccination program available has been progressing worldwide. To mitigate the COVID-19 contraction, different contact tracing applications have been utilized such as Thai Chana from Thailand. This study aimed to predict factors affecting the perceived usability of Thai Chana by integrating the Protection Motivation Theory and Technology Acceptance Theory considering the System Usability Scale, utilizing deep learning neural network and random forest classifier. A total of 800 respondents were collected through convenience sampling to measure different factors such as understanding COVID-19, perceived severity, perceived vulnerability, perceived ease of use, perceived usefulness, attitude towards using, intention to use, actual system use, and perceived usability. In total, 97.32% of the deep learning neural network showed that understanding COVID-19 presented the most significant factor affecting perceived usability. In addition, random forest classifier produced a 92% accuracy with a 0.00 standard deviation indicating that understanding COVID-19 and perceived vulnerability led to a very high perceived usability while perceived severity and perceived ease of use also led to a high perceived usability. The findings of this study could be considered by the government to promote the usage of contact tracing applications even in other countries. Finally, deep learning neural network and random forest classifier as machine learning algorithms may be utilized for predicting factors affecting human behavior in technology or system acceptance worldwide.
Crassolide Induces G2/M Cell Cycle Arrest, Apoptosis, and Autophagy in Human Lung Cancer Cells via ROS-Mediated ER Stress Pathways
Authors: Lai Kuan-Ming , Wang Jou-Hsuan , Lin Shih-Chao , Wen Ya , Wu Chao-Liang , Su Jui-Hsin , Chen Chien-Chin , Lin Chi-Chien
Published: May 2022

Crassolide, a cembranoid diterpene extracted from the soft coral Lobophytum crissum, has been proven to possess antioxidant and immunomodulatory properties. In the present study, we assessed the anticancer effects of crassolide on human H460 non-small-cell lung cancer (NSCLC) cells. We found that crassolide exerted cytotoxic effects on H460 cancer cells in vitro, inducing G2/M phase arrest and apoptosis. In addition, in H460 cells exposed to crassolide, the expression of the autophagy-related proteins LC3-II and beclin was increased, while the expression of p62 was decreased. Moreover, inhibiting autophagy with chloroquine (CQ) suppressed the crassolide-induced G2/M arrest and apoptosis of H460 cells. Moreover, we also found that crassolide induced endoplasmic reticulum (ER) stress in lung cancer cells by increasing the expression of ER stress marker proteins and that the crassolide-induced G2/M arrest, apoptosis, and autophagy were markedly attenuated by the ER stress inhibitor 4-phenylbutyric acid (4-PBA). Furthermore, we found that crassolide promoted reactive oxygen species (ROS) production by H460 cells and that the ROS inhibitor N-acetylcysteine (NAC) decreased the crassolide-induced ER stress, G2/M arrest, apoptosis, and autophagy. In conclusion, our findings show that crassolide inhibits NSCLC cell malignant biological behaviors for the first time, suggesting that this effect may be mechanistically achieved by inducing G2/M arrest, apoptosis, and autophagy through ROS accumulation, which activates the ER stress pathway. As a result of our findings, we now have a better understanding of the molecular mechanism underlying the anticancer effect of crassolide, and we believe crassolide might be a candidate for targeted cancer therapy.
First-Void Urine Microbiome in Women with Chlamydia trachomatis Infection
Authors: Gaspari Valeria , Ceccarani Camilla , Severgnini Marco , Orioni Gionathan , Camboni Tania , Laghi Luca , Morselli Sara , Foschi Claudio , Marangoni Antonella , Consolandi Clarissa , Piraccini Bianca Maria
Published: May 2022

Background: Chlamydia trachomatis (CT) is the agent of the most common bacterial sexually transmitted infection worldwide. Until now, little information is available about the microbial composition of urine samples during CT urethritis. Therefore, in this study, we characterized the microbiome and metabolome profiles of first-void urines in a cohort of women with CT urethral infection attending an STI clinic. Methods: Based on CT positivity by nucleic acid amplification techniques on urine samples, the enrolled women were divided into two groups, i.e., “CT-negative” (n = 21) and “CT-positive” (n = 11). Urine samples were employed for (i) the microbiome profile analysis by means of 16s rRNA gene sequencing and (ii) the metabolome analysis by 1H-NMR. Results: Irrespective of CT infection, the microbiome of first-void urines was mainly dominated by Lactobacillus, L. iners and L. crispatus being the most represented species. CT-positive samples were characterized by reduced microbial biodiversity compared to the controls. Moreover, a significant reduction of the Mycoplasmataceae family—in particular, of the Ureaplasma parvum species—was observed during CT infection. The Chlamydia genus was positively correlated with urine hippurate and lactulose. Conclusions: These data can help elucidate the pathogenesis of chlamydial urogenital infections, as well as to set up innovative diagnostic and therapeutic approaches.
The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor
Authors: Parshina Elena A. , Orlov Eugeny E. , Zaraisky Andrey G. , Martynova Natalia Y.
Published: May 2022

Zyxin is an LIM-domain-containing protein that regulates the assembly of F-actin filaments in cell contacts. Additionally, as a result of mechanical stress, Zyxin can enter nuclei and regulate gene expression. Previously, we found that Zyxin could affect mRNA stability of the maternally derived stemness factors of Pou5f3 family in Xenopus laevis embryos through binding to Y-box factor1. In the present work, we demonstrate that Zyxin can also affect mRNA stability of the maternally derived retinoid receptor Rxrγ through the same mechanism. Moreover, we confirmed the functional link between Zyxin and Rxrγ-dependent gene expression. As a result, Zyxin appears to play an essential role in the regulation of the retinoic acid signal pathway during early embryonic development. Besides, our research indicates that the mechanism based on the mRNA destabilization by Zyxin may take part in the control of the expression of a fairly wide range of maternal genes.
Genipin, an Inhibitor of UCP2 as a Promising New Anticancer Agent: A Review of the Literature
Authors: Cho Young Seok
Published: May 2022

Genipin is a protein cross-linking agent extracted from Gardenia (Gardenia jasminoides Ellis) fruits. This fruit has conventionally been used as a Chinese herbal medicine for the treatment of inflammation and jaundice and as an edible colorant in oriental countries. Uncoupling protein (UCP)-2 is a member of the family of uncoupling proteins, which are anion transporters positioned in the mitochondrial inner membrane. Genipin has been shown to have hepatoprotective activity, acting as an effective antioxidant and inhibitor of mitochondrial UCP2, and is also reported to exert significant anticancer effects. In this review, the author presents the latest progress of genipin as an anticancer agent and concisely describes its various mechanisms of action. In brief, genipin inhibits UCP2 to attenuate generation of reactive oxygen species (ROS), leading to ROS/c-Jun N-terminal kinase-dependent apoptosis of cancer cells. Genipin also increases the tissue inhibitors of matrix metalloproteases (MMP)-2, a kind of tumor promoter in a variety of cancers, as well as induces caspase-dependent apoptosis in in vitro and in vivo models. These findings suggest that genipin can serve as a promising novel antitumor agent that could be applicable for chemotherapy and/or chemoprevention for cancers.
Edible Bioactive Film with Curcumin: A Potential “Functional” Packaging?
Authors: Oliveira Filho Josemar Gonçalves , Egea Mariana Buranelo
Published: May 2022

Edible packaging has been developed as a biodegradable and non-toxic alternative to traditional petroleum-based food packaging. Biopolymeric edible films, in addition to their passive protective function, may also play a bioactive role as vehicles for bioactive compounds of importance to human health. In recent years, a new generation of edible food packaging has been developed to incorporate ingredients with functional potential that have beneficial effects on consumer health. Curcumin, a bioactive compound widely used as a natural dye obtained from turmeric rhizomes (Curcuma longa L.), has a broad spectrum of beneficial properties for human health, such as anti-inflammatory, anti-hypertensive, antioxidant, anti-cancer, and other activities. To demonstrate these properties, curcumin has been explored as a bioactive agent for the development of bioactive packaging, which can be referred to as functional packaging and used in food. The aim of this review was to describe the current and potential research on the development of functional-edible-films incorporating curcumin for applications such as food packaging.
Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson’s Disease
Authors: Han Sangeun , Lim Sabina , Yeo Sujung
Published: May 2022

Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN), reducing dopaminergic levels in the striatum and affecting motor control. Herein, we investigated the potential relationship between integrin α7 (ITGA7) and α-synuclein (α-syn) in the muscle of methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-induced mice and C2C12 cells. To characterize the pathology of PD, we examined the expression of tyrosine hydroxylase (TH) in the SN of the midbrain. Compared with the control group, MPTP-treated mice showed a significant decrease in TH expression in the SN, accompanied by a significant decrease in muscle ITGA7 expression. Compared with the control group, α-syn expression was increased in the MPTP group. Furthermore, the pattern of α-syn expression in the MPTP group was similar to the ITGA7 expression pattern in the control group (linear forms). To determine the relationship between ITGA7 and PD, we examined the expression of ITGA7 and α-syn after ITGA7 knockdown using siRNA in C2C12 cells. ITGA7 expression significantly decreased while α-syn expression significantly increased in siRNA-treated C2C12 cells. These results suggest that decreased ITGA7 muscle expression could increase α-syn expression. Moreover, α-syn accumulation, induced by decreased muscle ITGA7, might contribute to PD pathology.
Diguanylate Cyclase (DGC) Implicated in the Synthesis of Multiple Bacteriocins via the Flagellar-Type III Secretion System Produced by Pectobacterium carotovorum subsp. carotovorum
Authors: Lagitnay Ruchi Briam James Sersenia , Chen Han-Ling , Chen Yen-Chun , Chuang Duen-Yau
Published: May 2022

The plant pathogen Pectobacterium carotovorum subsp. carotovorum (previously Erwinia carotovora subsp. carotovora) causes soft rot and stem rot diseases in a variety of crops, including Chinese cabbage, potato, and tomato. The flagellar-type III secretion systems were used by Pcc’s virulence mechanism to export proteins or bacteriocins to the outside of the cell. DGC, a virulence factor that cyclizes c-di-GMP, a common secondary signal in physiological processes and toxin control systems of many bacteria, was discovered in Pcc’s genomic DNA. The dgc gene in Pcc was blocked using the method of homologous recombination in our study. In the in vivo setting, the results demonstrated that the dgc knockout strain does not release low molecular weight bacteriocins. The bacteriocin gene (carocin S2, carocin S3, carocin S4) and the flagellar-type III secretion system genes were also unable to be transcribed by the dgc knockout strain in the transcription experiment. We also observed that the amount of bacteriocin expressed changed when the amount of L-glutamine in the environment exceeded a particular level. These data suggested that L-glutamine influenced physiological processes in Pcc strains in some way. We hypothesized a relationship between dgc and the genes involved in Pcc LMWB external export via the flagellar-type secretion system based on these findings. In this study, the current findings led us to propose a mechanism in which DGC’s cyclic di-GMP might bind to receptor proteins and positively regulate bacteriocin transcription as well as the synthesis, mobility, and transport of toxins.
Improvement of Glycaemia and Endothelial Function by a New Low-Dose Curcuminoid in an Animal Model of Type 2 Diabetes
Authors: Oliveira Sara , Monteiro-Alfredo Tamaeh , Henriques Rita , Ribeiro Carlos Fontes , Seiça Raquel , Cruz Teresa , Cabral Célia , Fernandes Rosa , Piedade Fátima , Robalo Maria Paula , Matafome Paulo , Silva Sónia
Published: May 2022

Curcumin has been suggested as a promising treatment for metabolic diseases, but the high doses required limit its therapeutic use. In this study, a new curcuminoid is synthesised to increase curcumin anti-inflammatory and antioxidant potential and to achieve hypoglycaemic and protective vascular effects in type 2 diabetic rats in a lower dose. In vitro, the anti-inflammatory effect was determined through the Griess reaction, and the antioxidant activity through ABTS and TBARS assays. In vivo, Goto-Kakizaki rats were treated for 2 weeks with the equimolar dose of curcumin (40 mg/kg/day) or curcuminoid (52.4 mg/kg/day). Fasting glycaemia, insulin tolerance, plasma insulin, insulin signalling, serum FFA, endothelial function and several markers of oxidative stress were evaluated. Both compounds presented a significant anti-inflammatory effect. Moreover, the curcuminoid had a marked hypoglycaemic effect, accompanied by higher GLUT4 levels in adipose tissue. Both compounds increased NO-dependent vasorelaxation, but only the curcuminoid exacerbated the response to ascorbic acid, consistent with a higher decrease in vascular oxidative and nitrosative stress. SOD1 and GLO1 levels were increased in EAT and heart, respectively. Altogether, these data suggest that the curcuminoid developed here has more pronounced effects than curcumin in low doses, improving the oxidative stress, endothelial function and glycaemic profile in type 2 diabetes.
Identification and Distribution of Human-Biting Ticks in Northwestern Spain
Authors: Vieira Lista María Carmen , Belhassen-García Moncef , Vicente Santiago María Belén , Sánchez-Montejo Javier , Pedroza Pérez Carlos , Monsalve Arteaga Lía Carolina , Herrador Zaida , del Álamo-Sanz Rufino , Benito Agustin , Soto López Julio David , Muro Antonio
Published: May 2022

Ticks transmit a wide diversity of pathogens to a great variety of hosts, including humans. We conducted a tick surveillance study in northwestern Spain between 2014 and 2019. Ticks were removed from people and identified. Tick numbers, species, development stages, the timeline, seasonal and geographical distribution and epidemiological characteristics of people bitten by ticks were studied. We collected ticks from 8143 people. Nymphs of I. ricinus were the most frequently collected. Rhipicephalus bursa, R. sanguineus s.l., Hy. marginatum, Hy. lusitanicum, D. marginatus, D. reticulatus and H. punctata were also found, with adults as the main stage. The number of collected Hyalomma spp. and R. bursa has been progressively increasing over time. Although bites occurred throughout the year, the highest number of incidents was reported from April to July. The distribution patterns of the tick species were different between the north and the south of the region, which was related to cases detected in humans of the pathogens they carried. Adult men were more likely to be bitten by ticks than women. Ticks were most frequently removed from adults from the lower limbs, while for children, they were mainly attached to the head. Epidemiological surveillance is essential given the increase in tick populations in recent years, mainly of species potentially carrying pathogens causing emerging diseases in Spain, such as Crimean–Congo hemorrhagic fever (CCFH).
Molecular and Pathogenic Characterization of Fusarium Species Associated with Corm Rot Disease in Saffron from China
Authors: Mirghasempour Seyed Ali , Studholme David J. , Chen Weiliang , Zhu Weidong , Mao Bizeng
Published: May 2022

Saffron (Crocus sativus L.) is a commercial spice crop well-known throughout the world, valued for culinary, colorant, and pharmaceutical purposes. In China, Fusarium nirenbergiae was detected as causative agent of saffron corm rot, the most pervasive disease for the first time in 2020. In the present study, 261 Fusarium-like isolates were recovered from 120 rotted corms in four saffron producing fields at Zhejiang, Shanghai, and Yunnan provinces, China, in 2021. A combination of morpho-cultural features and multilocus sequence analysis (MLSA) of the concatenated rpb2 (DNA-directed RNA polymerase II largest subunit) and tef1 (translation elongation factor 1-α) partial sequences showed that the isolates from saffron belong to Fusarium nirenbergiae as well as F. commune, and F. annulatum with isolation frequencies of 58.2%, 26.8%, and 14.9%, respectively. Notably, F. commune was more prevalent than F. annulatum in the collected samples. Pathogenicity tests confirmed that both species were pathogenic on saffron corm. This is the first report of F. annulatum and F. commune causing corm rot of saffron, globally. Outcomes of the current research demonstrate that Fusarium spp. associated with saffron corm rot are more diverse than previously reported. Furthermore, some plants were infected by two or more Fusarium species. Our findings broaden knowledge about Fusarium spp. that inflict corm rot and assist the development of control measures.
Evolution of Microstructural and Mechanical Properties during Cold-Rolling Deformation of a Biocompatible Ti-Nb-Zr-Ta Alloy
Authors: Dan Alexandru , Angelescu Mariana Lucia , Serban Nicolae , Cojocaru Elisabeta Mirela , Zarnescu-Ivan Nicoleta , Cojocaru Vasile Danut , Galbinasu Bogdan Mihai
Published: May 2022

In this study, a Ti-32.9Nb-4.2Zr-7.5Ta (wt%) titanium alloy was produced by melting in a cold crucible induction in a levitation furnace, and then deforming by cold rolling, with progressive deformation degrees (thickness reduction), from 15% to 60%, in 15% increments. The microstructural characteristics of the specimens in as-received and cold-rolled conditions were determined by XRD and SEM microscopy, while the mechanical characteristics were obtained by tensile and microhardness testing. It was concluded that, in all cases, the Ti-32.9Nb-4.2Zr-7.5Ta (wt%) showed a bimodal microstructure consisting of Ti-β and Ti-α″ phases. Cold deformation induced significant changes in the microstructural and the mechanical properties, leading to grain-refinement, crystalline cell distortions and variations in the weight-fraction ratio of both Ti-β and Ti-α″ phases, as the applied degree of deformation increased from 15% to 60%. Changes in the mechanical properties were also observed: the strength properties (ultimate tensile strength, yield strength and microhardness) increased, while the ductility properties (fracture strain and elastic modulus) decreased, as a result of variations in the weight-fraction ratio, the crystallite size and the strain hardening induced by the progressive cold deformation in the Ti-β and Ti-α″ phases.
Recycled Untreated Rubber Waste for Controlling the Alkali–Silica Reaction in Concrete
Authors: Abbas Safeer , Ahmed Ali , Waheed Ayesha , Abbass Wasim , Yousaf Muhammad , Shaukat Sbahat , Alabduljabbar Hisham , Awad Youssef Ahmed
Published: May 2022

Recycled rubber waste (RW) is produced at an alarming rate due to the deposition of 1.5 billion scrap tires annually around the globe, which causes serious threats to the environment due to its open land filling issues. This study investigates the potential application of RW in concrete structures for mitigating the alkali–silica reaction (ASR). Various proportions of RW (5%, 10%, 15%, 20%, and 25%) partially replaced the used aggregates. RW was procured from a local rubber recycling unit. Cubes, prisms, and mortar bar specimens were prepared using a mixture design recommended by ASTM C1260 and tested for evaluating the compressive and flexural strengths and expansion in an ASR conducive environment for specimens incorporating RW. It was observed that the compressive and flexural strength decreased for specimens incorporating RW compared to that of the control specimens without RW. For example, an 18% and an 8% decrease in compressive and flexural strengths, respectively, were observed for specimens with 5% of RW by aggregates volume at 28 days. Mortar bar specimens without RW showed an expansion of 0.23% and 0.28% at 14 and 28 days, respectively, indicating the potential ASR reactivity in accordance with ASTM C1260. A decrease in expansion was observed for mixtures incorporating RW. Specimens incorporating 20% of RW by aggregate volume showed expansions of 0.17% at 28 days, within the limit specified by ASTM C1260. Moreover, specimens incorporating RW showed a lower reduction in compressive and flexural strengths under an ASR conducive environment compared to that of the control specimen without RW. Micro-structural analysis also showed significant micro-cracking for specimens without RW due to ASR. However, no surface cracks were observed for specimens incorporating RW. It can be argued that the use of RW in the construction industry assists in reducing the landfill depositing issues with the additional benefit of limiting the ASR expansion.
Structural Safety of the Steel Hall under Dynamic Excitation Using the Relative Probabilistic Entropy Concept
Authors: Bredow Rafał , Kamiński Marcin
Published: May 2022

This work aimed to analyze the reliability of a steel hall that was recently erected in central Poland subjected to dynamic wind excitation using the stochastic finite element method. Reliability analysis was completed using the relative entropy concept delivered by Bhattacharyya and contrasted with the first-order reliability method recommended by the engineering design codes. Bhattacharyya probabilistic relative entropy was additionally rescaled in this study to fit the demands and recommended admissibility intervals given in Eurocode 0. The finite element method study was carried out thanks to a discrete model created in the system ABAQUS 2019, while all further statistical and probabilistic computations were programmed and completed in the symbolic environment of MAPLE 2019. Contrary to most engineering analyses in steel structure areas, this study included the important warping effect while designing the hall ridges and the purlins. Dynamic structural responses were determined via the Hilber-Hughes-Taylor algorithm and their series were numerically obtained for a series of input uncertainty parameters representing several mechanical and environmental quantities. The generalized 10th order iterative stochastic perturbation technique was contrasted in this context with statistical estimators from the Monte Carlo simulations and numerical integration resulting from the semi-analytical approach. The key research finding of this study was an extremely good coincidence between the FORM indices and the rescaled relative probabilistic entropies for the given stochastic excitations, which additionally did not depend on a choice of one of the three proposed numerical approaches.
Mechanical and Durability Performance of Coconut Fiber Reinforced Concrete: A State-of-the-Art Review
Authors: Ahmad Jawad , Majdi Ali , Al-Fakih Amin , Deifalla Ahmed , Althoey Fadi , El Ouni Mohamed , El-Shorbagy Mohammed
Published: May 2022

The push for sustainability in the construction sector has demanded the use of increasingly renewable resources. These natural fibers are biodegradable and non-toxic, and their mechanical capabilities are superior to those of synthetic fibers in terms of strength and durability. A lot of research recommends coconut fibers as an alternative to synthetic fibers. However, the knowledge is scattered, and no one can easily judge the suitability of coconut fibers in concrete. This paper presents a summary of research progress on coconut fiber (natural fibers) reinforced concrete. The effects of coconut fibers on the properties of concrete are reviewed. Factors affecting the fresh, hardened, and durability properties of concrete reinforced with coconut fiber are discussed. Results indicate that coconut fiber improved the mechanical performance of concrete due to crack prevention, similar to the synthetic fibers but decreased the flowability of concrete. However, coconut fibers improved flexure strength more effectively than compressive strength. Furthermore, improvement in some durability performance was also observed, but less information is available in this regard. Moreover, the optimum dose is an important parameter for high-strength concrete. The majority of researchers indicate that 3.0% coconut fiber is the optimum dose. The overall study demonstrates that coconut fibers have the creditability to be used in concrete instead of synthetic fibers.
Simulation of Diffusion-Controlled Growth of Interdependent Nuclei under Potentiostatic Conditions
Authors: Kosov Alexander V. , Grishenkova Olga V. , Isaev Vladimir A. , Zaikov Yuriy
Published: May 2022

The problem of diffusion-controlled growth following an instantaneous nucleation event was studied within the framework of a new numerical model, considering the spatial distribution of hemispherical nuclei on the electrode surface and the mutual influence of growing nuclei via the collision of 3D diffusion fields. The simulation of the diffusion-controlled growth of hexagonal and random ensembles was performed at the overpotential-dependent number density of nuclei. The diffusion flow to each nucleus within a random ensemble was simulated by the finite difference method using the derived analytical expressions for the surface areas and the volumes formed at the intersection of 3D diffusion fields with the side faces of a virtual right prism with a Voronoi polygon base. The implementation of this approach provides an accurate calculation of concentration profiles, time dependences of the size of nuclei, and current transients. The results, including total current density transients, growth exponents, and nucleus size distribution, were compared with models developed within the concept of planar diffusion zones, the mean-field approximation and the Brownian dynamics simulation method, as well as with experimental data from the literature. The prospects of the model for studying the initial stages of electrocrystallization were discussed.
Liquid Guayule Natural Rubber, a Sustainable Processing Aid, Enhances the Processability, Durability and Dynamic Mechanical Properties of Rubber Composites
Authors: Ren Xianjie , Barrera Cindy S. , Tardiff Janice L. , Gil Andres , Cornish Katrina
Published: May 2022

Petroleum-based oils are widely used as processing aids in rubber composites to improve processability but can adversely affect rubber composite performance and increase carbon footprint. In this research, liquid guayule natural rubber (LGNR), produced from guayule natural rubber, was used as a renewable processing aid to replace naphthenic oil (NO) in Hevea natural rubber, styrene-butadiene rubber (SBR) and guayule natural rubber (GNR) composites. The rheological properties, thermal stability, glass transition temperature, dynamic mechanical properties, aging, and ozone resistance of rubber composites with and without NO or LGNR were compared. Natural and synthetic rubber composites made with LGNR had similar processability to those made with NO, but had improved thermal stability, mechanical properties after aging, and ozone resistance. This was due to the strong LGNR–filler interaction and additional crosslinks formed between LGNR and the rubber matrices. The glass transition temperature of SBR composites was reduced by LGNR because of its increased molecular mobility. Thus, unlike NO, LGNR processing aid can simultaneously improve rubber composite durability, dynamic performance and renewability. The commercialization of LGNR has the potential to open a new sustainable processing-aid market.
Influence of Diatomaceous Earth Particle Size on Mechanical Properties of PLA/Diatomaceous Earth Composites
Authors: Dobrosielska Marta , Dobrucka Renata , Brząkalski Dariusz , Frydrych Miłosz , Kozera Paulina , Wieczorek Monika , Jałbrzykowski Marek , Kurzydłowski Krzysztof J. , Przekop Robert E.
Published: May 2022

The fractionation of diatomaceous earth (DE) using sedimentation made it possible to obtain separate unbroken diatom fractions from broken or agglomerated bodies with a range of particle sizes. The produced filler was used to prepare polylactide (PLA)/diatomaceous earth biocomposite samples containing different particle sizes, which were subjected to mechanical testing (tensile strength, flexural strength, impact strength), colloidal testing (contact angle, color change test, SEM/EDS), and thermal testing (TGA, DSC, DMA). Modification of the PLA containing the smallest particle size with diatomaceous earth (Fraction 5) resulted in a higher impact strength compared to both the pure PLA and the PLA/DE composite that contained base diatomaceous earth. Furthermore, the melt flow rate was improved by more than 80 and 60% for the composite modified with fractionated diatomaceous earth (Fraction 4) compared to pure PLA and base diatomaceous earth, respectively. The elasticity of the composite was also improved from 3.3 GPa for pure polylactide to 4.4 GPa for the system containing the smallest diatomaceous earth particles (Fraction 5).
In Vitro Analysis of the Mechanical Properties of Hypoallergenic Denture Base Resins
Authors: Hinz Sebastian , Bensel Tobias , Bömicke Wolfgang , Boeckler Arne F.
Published: May 2022

The development of hypoallergenic denture resins is key to the treatment of patients with allergies to polymethyl methacrylate (PMMA). In this study, the in vitro mechanical properties of hypoallergenic and PMMA denture base resins were compared. Ninety-six test specimens of hypoallergenic denture base resins (Polyan Plus®, Sinomer, TMS Acetal Dental, Erkocryl) and 72 test specimens of PMMA-based denture base resins (Paladon 65, PalaXpress, SR-Ivocap) were fabricated. The flexural strength, elastic modulus, compressive strength, macro- and microhardness, average roughness, water absorption, and water solubility of the resins were measured. None of the hypoallergenic denture resins matched all the mechanical properties of the PMMA resins. Polyan Plus® and TMS Acetal Dental were closest to matching the mechanical properties of the PMMA resins, and TMS Acetal Dental had some superior properties. Consequently, Polyan Plus® and TMS Acetal Dental hypoallergenic resins are recommended for further investigation as potential alternatives to PMMA resins for the fabrication of removable dentures.
In Vitro Study of Laser-Assisted Prefabricated Ceramic Crown Debonding as Compared to Traditional Rotary Instrument Removal
Authors: Deeb Janina Golob , Crowell Andrew , Richey Kristen H. , Bencharit Sompop , Carrico Caroline K. , Williams Tiffany L. , Grzech-Leśniak Kinga
Published: May 2022

This study compared the laser and rotary removals of prefabricated zirconia crowns in primary anterior and permanent posterior teeth. Sixty-two extracted teeth were prepared for prefabricated zirconia crowns cemented with resin-modified glass-ionomer cement. Specimens underwent crown removals by a rotary handpiece, or erbium, chromium: yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser. Pulpal temperatures, removal times, and scanning electron microscopy (SEM) examinations were compared. The average crown removal time for rotary and laser methods was 80.9 ± 19.36 s and 353.3 ± 110.6 s, respectively, for anterior primary teeth; and 114.2 ± 32.1 s and 288.5 ± 76.1 s, respectively, for posterior teeth (p < 0.001). The maximum temperature for the rotary and laser groups was 22.2 ± 8.5 °C and 27.7 ± 1.6 °C for anterior teeth, respectively (p < 0.001); and 21.8 ± 0.77 °C and 25.8 ± 0.85 °C for the posterior teeth, respectively (p < 0.001). More open dentinal tubules appeared in the rotary than the laser group. The rotary handpiece removal method may be more efficient than the laser with lower pulpal temperature changes. However, the laser method does not create noticeable tooth or crown structural damage compared to the rotary method.
A Medicinal Halophyte Ipomoea pes-caprae (Linn.) R. Br.: A Review of Its Botany, Traditional Uses, Phytochemistry, and Bioactivity
Authors: Akinniyi Ganiyu , Lee Jeonghee , Kim Hiyoung , Lee Joon-Goo , Yang Inho
Published: May 2022

Ipomoea pes-caprae (Linn.) R. Br. (Convolvulaceae) is a halophytic plant that favorably grows in tropical and subtropical countries in Asia, America, Africa, and Australia. Even though this plant is considered a pan-tropical plant, I. pes-caprae has been found to occur in inland habitats and coasts of wider areas, such as Spain, Anguilla, South Africa, and Marshall Island, either through a purposeful introduction, accidentally by dispersal, or by spreading due to climate change. The plant parts are used in traditional medicine for treating a wide range of diseases, such as inflammation, gastrointestinal disorders, pain, and hypertension. Previous phytochemical analyses of the plant have revealed pharmacologically active components, such as alkaloids, glycosides, steroids, terpenoids, and flavonoids. These phytoconstituents are responsible for the wide range of biological activities possessed by I. pes-caprae plant parts and extracts. This review arranges the previous reports on the botany, distribution, traditional uses, chemical constituents, and biological activities of I. pes-caprae to facilitate further studies that would lead to the discovery of novel bioactive natural products from this halophyte.
Quality of Life Evaluation Using SRS-30 Score for Operated Children and Adolescent Idiopathic Scoliosis
Authors: Herdea Alexandru , Stancu Teodor Alexandru , Ulici Alexandru , Lungu Claudiu N. , Dragomirescu Mihai-Codrut , Charkaoui Adham
Published: May 2022

Background and objective: Adolescent idiopathic scoliosis (A.I.S.) is a disorder with a significant impact on health and self-image. This spinal deformity can affect between 2% and 4% of the adolescent population and may alter one’s quality of life. This study aims to assess the patient outcome, satisfaction, and quality of life following surgical treatment using the SRS-30 questionnaire. Materials and Methods: A number of 49 children and adolescent patients diagnosed with idiopathic scoliosis that had surgery were included in this study. They thoroughly completed the SRS-30 questionnaire before and after the surgery, based on which data analysis was carried on. Correlations between the test results and imagistic data (pre- and postoperative Cobb angle, correction rate of Cobb angle, number of instrumented spinal segments, and number of pedicle screws/laminar hooks used in the surgery) were performed. Results: Our results showed that 87.76% of the patients were girls, and the mean age at surgery was 14.83 years. Postoperatively, the Cobb angle improved significantly (p < 0.0001). The questionnaire domain “Satisfaction with management” improved dramatically after surgery, averaging 13.65 points (91% out of the maximum score). The average postoperative test score was 125.1 points. Statistically significant correlations were found between the correction rate and SRS-30 score improvement (p < 0.001), in total as well as per each domain of the survey, respectively. Comparing the questionnaire domains, “Self-image” was positively correlated with “Satisfaction with management” (p < 0.0001). Conclusions: Better correction rate led to higher values of SRS-30 score. Additionally, the younger the age at surgery is, the higher the score. The number of instrumented spinal segments does not alter the quality of life. Overall, the most crucial factor influencing patient satisfaction after surgical treatment is self-image.
Wearable Near-Field Communication Sensors for Healthcare: Materials, Fabrication and Application
Authors: Sun Xidi , Zhao Chengyan , Li Hao , Yu Huiwen , Zhang Jing , Qiu Hao , Liang Junge , Wu Jing , Su Mengrui , Shi Yi , Pan Lijia
Published: May 2022

The wearable device industry is on the rise, with technology applications ranging from wireless communication technologies to the Internet of Things. However, most of the wearable sensors currently on the market are expensive, rigid and bulky, leading to poor data accuracy and uncomfortable wearing experiences. Near-field communication sensors are low-cost, easy-to-manufacture wireless communication technologies that are widely used in many fields, especially in the field of wearable electronic devices. The integration of wireless communication devices and sensors exhibits tremendous potential for these wearable applications by endowing sensors with new features of wireless signal transferring and conferring radio frequency identification or near-field communication devices with a sensing function. Likewise, the development of new materials and intensive research promotes the next generation of ultra-light and soft wearable devices for healthcare. This review begins with an introduction to the different components of near-field communication, with particular emphasis on the antenna design part of near-field communication. We summarize recent advances in different wearable areas of near-field communication sensors, including structural design, material selection, and the state of the art of scenario-based development. The challenges and opportunities relating to wearable near-field communication sensors for healthcare are also discussed.
Design and Analysis of a Hybrid-Type RF MEMS Phase Detector in X-Band
Authors: Han Juzheng , Ding Dazhi
Published: May 2022

In this paper, we have designed, analyzed, and characterized a hybrid-type MEMS device for X-band phase shift measurement. The signal related to a phase shift of the inputs is fractionally in-line coupled by a MEMS beam and delivered to a thermoelectric power sensor, where the phase is ultimately converted into DC voltage output. With the hybrid of the MEMS beam and the thermoelectric power sensor, both in-line detection process and phase-DC voltage conversion is reserved, which is a benefit for large power capacity, good linearity property, and high-level integration density. In order to get a deep insight into the physical mechanisms involved in the phase detection process, a comprehensive analysis model is presented. The beam is modeled as a precise RLC circuit component, where the capacitance is related to the input power. The fabrication is compatible with GaAs monolithic microwave integrated circuit (MMIC) technology. Experimental results show that return loss is smaller than −11.3 dB and isolation is better than −9.3 dB over X-band. Phase shift detection from 0 to 180 degrees is verified for a large power range of 200–1600 mW (23–32 dBm). The perfect linearity property of the phase-detection sensitivity is demonstrated in the same power range. Low intermodulation distortion is also confirmed through measurement. It is revealed from the comparison between this work and other published results in the literature that this presented hybrid-type structure shows superiorities in both power handling ability and phase-detection linearity. It can be adopted in medium power signal applications with a high level of integration.
Design of Chopsticks-Shaped Heating Resistors for a Thermal Inkjet: Based on TaN Film
Authors: Lu Anjiang , Peng Xishun , Sun Qiliang , Cheng Jin , Xu Naitao , Xie Yibo , Ding Jie , Li Pangyue , Long Ji’an , Wu Jiawen
Published: May 2022

Efficient printing frequency is critical for thermal bubble inkjet printing, while the difficulty lies in the structural design and material selection of the heating resistors. In this paper, a TaN film was used as the main material of the heating resistors, and two TaN films were placed in parallel to form the chopsticks-shaped structure. The heating time was divided into two sections, in which 0–0.1 μs was the preheating and 1.2–1.8 μs was the primary heating. At 1.8 μs, the maximum temperature of the Si3N4 film could reach about 1100 °C. At the same time, the SiO2 film was added between the TaN film and Si3N4 film as a buffer layer, which effectively avoided the rupture of the Si3N4 film due to excessive thermal stress. Inside the inkjet print head, the maximum temperature of the chamber reached about 680 °C at 2.5 μs. Due to the high power of the heating resistors, the working time was greatly reduced and the frequency of the inkjet printing was effectively increased. At the interface between the back of the chip and the cartridge, the SiO2 film was used to connect to ensure a timely ink supply. Under the condition of 12 V at 40 kHz, the inkjet chip could print efficiently with 10 nozzles at the same time. The inkjet chip proposed in this paper is not limited to only office printing, but also provides a new reference for 3D printing, cell printing, and vegetable and fruit printing.
Felodipine Determination by a CdTe Quantum Dot-Based Fluorescent Probe
Authors: Lv Yuguang , Cheng Yuqing , Lv Kuilin , Zhang Guoliang , Wu Jiang
Published: May 2022

In this work, a CdTe quantum dot-based fluorescent probe was synthesized to determine felodipine (FEL). The synthesis conditions, structure, and interaction conditions with FEL of CdTe quantum dots were analysed by fluorescence spectrophotometry, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), UV–visible spectroscopy, and TEM. The CdTe QD concentration was 2.0 × 10−4 mol/L. The amount of quantum dots controlled in the experiment was 0.8 mL. The controlled feeding ratio of N (Cd2+):N (Te2−):N (TGA) was 2:1:4, the heating temperature was 140 °C, the heating time was 60 min, and the pH of the QD precursor was adjusted to 11 for subsequent experiments. The UV–visible spectrum showed that the emission wavelength of CdTe quantum dots at 545 nm was the strongest and symmetric. The particle size of the synthesized quantum dots was approximately 5 nm. In the interaction of CdTe quantum dots with FEL, the FEL dosage was 1.0 mL, the optimal pH value of Tris-HCl buffer was 8.2, the amount of buffer was 1.5 mL, and the reaction time was 20 min. The standard curve of FEL was determined under the optimal synthesis conditions of CdTe quantum dots and reaction of CdTe quantum dots with FEL. The linear equation was Y = 3.9448x + 50.068, the correlation coefficient R2 was 0.9986, and the linear range was 5 × 10−6–1.1 × 10−4 mol/L. A CdTe quantum dot-based fluorescent probe was successfully constructed and could be used to determine the FEL tablet content.
Progress of Research on the Application of Nanoelectronic Smelling in the Field of Food
Authors: Sha Junjiang , Xu Chong , Xu Ke
Published: May 2022

In the past 20 years, the development of an artificial olfactory system has made great progress and improvements. In recent years, as a new type of sensor, nanoelectronic smelling has been widely used in the food and drug industry because of its advantages of accurate sensitivity and good selectivity. This paper reviews the latest applications and progress of nanoelectronic smelling in animal-, plant-, and microbial-based foods. This includes an analysis of the status of nanoelectronic smelling in animal-based foods, an analysis of its harmful composition in plant-based foods, and an analysis of the microorganism quantity in microbial-based foods. We also conduct a flavor component analysis and an assessment of the advantages of nanoelectronic smelling. On this basis, the principles and structures of nanoelectronic smelling are also analyzed. Finally, the limitations and challenges of nanoelectronic smelling are summarized, and the future development of nanoelectronic smelling is proposed.