bluuebunny/crossref_metadata_2025 huggingface dataset:
New Records of Anopheles benarrochi B (Diptera: Culicidae) in Malaria Hotspots in the Amazon Regions of Ecuador and Peru
Authors: Morales Viteri Diego , Herrera-Varela Manuela , Albuja Maribel , Quiroga Cristina , Diaz Gloria , del Aguila Morante Clara , Ramirez Dario , Vinetz Joseph M , Bickersmith Sara A , Conn Jan E
Published: January 2021

The increase in malaria transmission in the Amazon region motivated vector control units of the Ministry of Health of Ecuador and Peru to investigate Anopheles (Diptera: Culicidae) species present in transmission hotspots. Mosquitoes were collected using prokopack aspirators and CDC light traps (Ecuador) and human landing catch in Peru. In Ecuador, 84 Anopheles were captured from Pastaza, Morona Santiago, and Orellana provinces and identified morphologically [An. (An.) apicimacula Dyar and Knab, An. (Nys.) near benarrochi, An. (Nys.) near oswaldoi, An. (Nys.) near strodei, An. (An.) nimbus (Theobald, 1902), and An. (Nyssorhynchus) sp.]. In Peru, 1,150 Anopheles were collected in Andoas District. A subsample of 166 specimens was stored under silica and identified as An. near oswaldoi, An. darlingi, and An. (An.) mattogrossensis Lutz and Neiva. COI barcode region sequences were obtained for 137 adults (107 from Peru, 30 from Ecuador) identified by ITS2 PCR-RFLP as An. benarrochi Gabaldon, Cova Garcia, and Lopez and retained in the final analysis. Haplotypes from the present study plus An. benarrochi B GenBank sequences grouped separately from Brazilian An. benarrochi GenBank sequences by 44 mutation steps, indicating that the present study specimens were An. benarrochi B. Our findings confirm the presence of An. benarrochi B in Ecuador and reported here for the first time from the Amazonian provinces of Orellana and Morona Santiago. Furthermore, we confirm that the species collected in Andoas District in the Datem del Maranon Province, Peru, is An. benarrochi B, and we observed that it is highly anthropophilic. Overall, the known distribution of An. benarrochi B has been extended and includes southern Colombia, much of Peru and eastern Ecuador.
The Common Market Makes Us Richer and Brings Us Closer Together: An Impact Assessment of the Common Market Project at Nyarugusu Refugee Camp
Authors: Kim Youngwan , Jeong Heeyul , Sung Sangmi
Published: January 2021

In recent decades, the number of refugees in protracted stateless situations has steadily risen. These vulnerable individuals face serious economic and political issues in their host communities. We assessed the common market project in Tanzania’s Nyarugusu refugee camp, examining its impact on refugees’ self-reliance and its role in determining peaceful coexistence between refugees and host communities. Through field research and empirical analysis of original survey data gathered from 473 refugee households and 505 host community households, we demonstrate that use of the common market has increased the incomes of both refugees and host communities. Furthermore, interactions within the common market have improved the relationship between refugees and host communities, bringing deeper trust between them. This study supports the market-based approach targeting refugees and host communities near refugee camps as an alternative to the conventional humanitarian aid methods. This approach could effectively ameliorate prolonged refugee crises around the world, where people suffer from decreasing resources and increasing anti-refugee sentiments.
Hypercalcemia an exceptional complication in upper urinary tract urothelial carcinoma
Authors: Jandou Issam , Wichou Elmehdi , Ettanji Adnane , Moataz Amine , Mohammed Dakir , Debbagh Adil , Aboutaieb Rachid
Published: January 2021

Tumors of the upper urinary tract are discovered, either by clinical symptomatology or as part of the evaluation of a bladder tumor. Hypercalcemia is one of the most common paraneoplastic syndromes and an exceptional complication of urothelial carcinoma of the upper tract. Several physiopathological mechanisms have been proposed to explain this rare and serious complication. Hypercalcemia is often correlated with tumors with a poor prognosis.
Text mining Mill: Computationally detecting influence in the writings of John Stuart Mill from library records
Authors: O’Neill Helen , Welsh Anne , Smith David A. , Roe Glenn , Terras Melissa
Published: January 2021

How can computational methods illuminate the relationship between a leading intellectual, and their lifetime library membership? We report here on an international collaboration that explored the interrelation between the reading record and the publications of the British philosopher and economist John Stuart Mill, focusing on his relationship with the London Library, an independent lending library of which Mill was a member for 32 years. Building on detailed archival research of the London Library’s lending and book donation records, a digital library of texts borrowed, and publications produced was assembled, which enabled natural language processing approaches to detect textual reuse and similarity, establishing the relationship between Mill and the Library. Text mining the books Mill borrowed and donated against his published outputs demonstrates that the collections of the London Library influenced his thought, transferred into his published oeuvre, and featured in his role as political commentator and public moralist. We reconceive archival library issue registers as data for triangulating against the growing body of digitized historical texts and the output of leading intellectual figures. We acknowledge, however, that this approach is dependent on the resources and permissions to transcribe extant library registers, and on access to previously digitized sources. Related copyright and privacy restrictions mean our approach is most likely to succeed for other leading eighteenth- and nineteenth-century figures.
Female Veteran Use of Palliative and Hospice Care: A Scoping Review
Authors: Varilek Brandon M , Isaacson Mary J
Published: January 2021

Introduction

The number of female veterans in the USA in the age range of 55-64 years increased 7-fold from 2000 to 2015. Female veterans are more likely to suffer from certain mental health disorders, respiratory diseases, neurologic diseases, and some forms of cancer when compared to their male counterparts. Veterans Affairs (VA) healthcare providers need to be prepared to care for this growth of female veterans with serious illness. These serious illnesses require appropriate medical management, which often includes palliative care. It is imperative to determine how VA healthcare providers integrate palliative and hospice care for this population. The purpose of our scoping review was to explore the palliative and hospice care literature specific to female veterans to learn: (1) what evidence is available regarding female veterans’ use of palliative and hospice care? (2) To meet the needs of this growing population, what gaps exist specific to female veterans’ use of palliative and hospice care?

Methods

A scoping review methodology was employed following the nine-step process described by the Joanna Briggs Institute for conducting scoping reviews.

Results

Nineteen articles met the inclusion criteria. Fourteen quantitative articles were included which comprised 10 retrospective chart reviews, one randomized controlled trial, one correlation, one quality improvement, and one cross-sectional. The remaining five were qualitative studies. The sample populations within the articles were overwhelmingly male and white. Content analysis of the articles revealed three themes: quality of end of life care, distress, and palliative care consult.

Conclusions

The female veteran population is increasing and becoming more ethnically diverse. Female veterans are not well represented in the literature. Our review also uncovered a significant gap in the study methodologies. We found that retrospective chart reviews dominated the palliative and hospice care literature specific to veterans. More prospective study designs are needed that explore the veteran and family experience while receiving end of life care. With the rising number of older female veterans and their risk for serious illness, it is imperative that research studies purposefully recruit, retain, analyze, and report female veteran statistics along with their male counterparts. We can no longer afford to disregard the value of the female veterans’ perspective.
Bright Light Treatment of Combat-related PTSD: A Randomized Controlled Trial
Authors: Youngstedt Shawn D , Kline Christopher E , Reynolds Alexandria M , Crowley Shannon K , Burch James B , Khan Nidha , Han SeungYong
Published: January 2021

Introduction

Post-traumatic stress disorder (PTSD) is a prevalent consequence of combat with significant associated morbidity. Available treatments for PTSD have had limitations, suggesting a need to explore alternative or adjuvant treatments. Numerous rationales for bright light treatment of PTSD include its benefits for common PTSD comorbidities of depression, anxiety, and circadian misalignment and its relative ease of use with few side effects. The primary aims of this research were to examine the effects of bright light treatment for combat-related PTSD and associated morbidity.

Materials and Methods

A randomized controlled trial was performed in N = 69 veterans with PTSD attributable to combat in Afghanistan and/or Iraq. Following a 1-week baseline, participants were randomized to 4 weeks of daily morning bright light treatment (10,000 lux for 30 min/day) or a control treatment (inactivated negative ion generator). At baseline and at the end of treatment, participants were rated blindly on the Clinician Assessed PTSD Scale (CAPS), the Clinical Global Impressions Scale (CGI), and the Hamilton Depression Scale and rated themselves on the PTSD Checklist-Military (PCL-M). Following baseline and each treatment week, participants completed self-reported scales of state anxiety, depression, and sleep, and sleep and the circadian rhythm of wrist activity were also assessed with wrist actigraphy.

Results

Compared with the control treatment, bright light elicited significantly greater improvements in the CAPS and CGI-Improvement. The bright light also elicited a significantly greater rate of treatment response (reduction ≥33%) for the CAPS (44.1% vs. 8.6%) and PCL-M (33% vs. 6%), but no participant had remission from PTSD. Changes in depression, anxiety, and sleep did not differ between treatments. Improvement in CAPS was significantly correlated with a phase advance of the circadian rhythm of wrist activity.

Conclusions

The most comprehensive study on the topic to date indicated significant short-term efficacy of bright light treatment on the primary variables (CAPS and CGI) with clinical relevance (i.e., treatment response) in veterans with chronic PTSD who did not report extremely high habitual light exposure. No significant effects were found for anxiety, depression, or sleep disturbance. Further research is warranted, particularly exploration of circadian phase-shifting mechanisms of bright light for PTSD.
The galaxy–halo connection of emission-line galaxies in IllustrisTNG
Authors: Hadzhiyska Boryana , Tacchella Sandro , Bose Sownak , Eisenstein Daniel J
Published: January 2021

We employ the hydrodynamical simulation IllustrisTNG-300-1 to explore the halo occupation distribution (HOD) and environmental dependence of luminous star-forming emission-line galaxies (ELGs) at z ∼ 1. Such galaxies are key targets for current and upcoming cosmological surveys. We select model galaxies through cuts in colour–colour space allowing for a direct comparison with the Extended Baryon Oscillation Spectroscopic Survey and the Dark Energy Spectroscopic Instrument (DESI) surveys and then compare them with galaxies selected based on specific star formation rate (sSFR) and stellar mass. We demonstrate that the ELG populations are twice more likely to reside in lower density regions (sheets) compared with the mass-selected populations and twice less likely to occupy the densest regions of the cosmic web (knots). We also show that the colour-selected and sSFR-selected ELGs exhibit very similar occupation and clustering statistics, finding that the agreement is best for lower redshifts. In contrast with the mass-selected sample, the occupation of haloes by a central ELG peaks at ∼20 per cent. We furthermore explore the dependence of the HOD and the autocorrelation on environment, noticing that at fixed halo mass, galaxies in high-density regions cluster about 10 times more strongly than low-density ones. This result suggests that we should model carefully the galaxy–halo relation and implement assembly bias effects into our models (estimated at ∼4 per cent of the clustering of the DESI colour-selected sample at z = 0.8). Finally, we apply a simple mock recipe to recover the clustering on large scales (r ≳ 1 Mpc h−1) to within 1 per cent by augmenting the HOD model with an environment dependence, demonstrating the power of adopting flexible population models.
Tracing the evolution of ultraluminous infrared galaxies into radio galaxies with low frequency radio observations
Authors: Nandi S , Das M , Dwarakanath K S
Published: January 2021

We present radio observations of ultraluminous infrared galaxies (ULIRGs) using the Giant Metrewave Radio Telescope (GMRT) and combine them with archival multifrequency observations to understand whether ULIRGs are the progenitors of the powerful radio loud galaxies in the local Universe. ULIRGs are characterized by large infrared luminosities (LIR > 1012 L⊙), large dust masses (∼108 M⊙), and vigorous star formation (star formation rates ∼10–100 M⊙ yr−1). Studies show that they represent the end stages of mergers of gas-rich spiral galaxies. Their luminosity can be due to both starburst activity and active galactic nuclei (AGNs). We study a sample of 13 ULIRGs that have optically identified AGN characteristics with 1.28 GHz GMRT observations. Our aim is to resolve any core-jet structures or nuclear extensions and hence examine whether the ULIRGs are evolving into radio loud ellipticals. Our deep, low frequency observations show marginal extension for only one source. However, the integrated radio spectra of 9 ULIRGs show characteristics that are similar to that of GPS/CSS/CSO/young radio sources. The estimated spectral ages are 0.4–20 Myr and indicate that they are young radio sources and possible progenitors of radio galaxies. Hence, we conclude that although most ULIRGs do not show kpc scale extended radio emission associated with nuclear activity, their radio spectral energy distributions do show signatures of young radio galaxies.
STARFORGE: the effects of protostellar outflows on the IMF
Authors: Guszejnov Dávid , Grudić Michael Y , Hopkins Philip F , Offner Stella S R , Faucher-Giguère Claude-André
Published: January 2021

The initial mass function (IMF) of stars is a key quantity affecting almost every field of astrophysics, yet it remains unclear what physical mechanisms determine it. We present the first runs of the STAR FORmation in Gaseous Environments project, using a new numerical framework to follow the formation of individual stars in giant molecular clouds (GMCs) using the gizmo code. Our suite includes runs with increasingly complex physics, starting with isothermal ideal magnetohydrodynamics (MHD) and then adding non-isothermal thermodynamics and protostellar outflows. We show that without protostellar outflows the resulting stellar masses are an order of magnitude too high, similar to the result in the base isothermal MHD run. Outflows disrupt the accretion flow around the protostar, allowing gas to fragment and additional stars to form, thereby lowering the mean stellar mass to a value similar to that observed. The effect of jets upon global cloud evolution is most pronounced for lower mass GMCs and dense clumps, so while jets can disrupt low-mass clouds, they are unable to regulate star formation in massive GMCs, as they would turn an order unity fraction of the mass into stars before unbinding the cloud. Jets are also unable to stop the runaway accretion of massive stars, which could ultimately lead to the formation of stars with masses ${\gt}500\, \mathrm{M}_{\rm \odot }$. Although we find that the mass scale set by jets is insensitive to most cloud parameters (i.e. surface density, virial parameter), it is strongly dependent on the momentum loading of the jets (which is poorly constrained by observations) as well as the temperature of the parent cloud, which predicts slightly larger IMF variations than observed. We conclude that protostellar jets play a vital role in setting the mass scale of stars, but additional physics are necessary to reproduce the observed IMF.
Voclosporin: a novel calcineurin inhibitor with no impact on mycophenolic acid levels in patients with SLE
Authors: van Gelder Teun , Huizinga Robert B , Lisk Laura , Solomons Neil
Published: January 2021

Background

An open-label phase 1 study was conducted to evaluate the effect of voclosporin following dosing with mycophenolate mofetil (MMF) on blood levels of mycophenolic acid (MPA, the active moiety of MMF) and MPA glucuronide (MPAG, the pharmacologically inactive metabolite of MMF) in subjects with systemic lupus erythematosus (SLE) and to assess the safety and tolerability of the combination.

Methods

MMF was orally administered at a dose of 1 g twice a day for at least 28 days prior to the study and continued at the same dose throughout the study. Voclosporin was orally administered at a dose of 23.7 mg twice a day for 7 consecutive days (Days 1–7), starting on the evening of Day 1 and ending with the morning dose on Day 7. Dense pharmacokinetic blood samples were collected pre-dose in the morning and from 0.25 to 12 h after the morning doses. Analyses were derived by non-compartmental methods.

Results

In 24 patients, MPA exposure [maximum serum concentration (Cmax) and area under the concentration curve from time 0 to 12 h (AUC0–12)] was similar in the presence and absence of voclosporin, with treatment ratios of 0.94 and 1.09, respectively [Cmax 16.5 μg/mL (Day 1) versus 15.8 (Day 7), AUC0–12 39.1 μg/h/mL (Day 1) versus 40.8 (Day 7)]. MPAG exposure showed a small increase in the presence of voclosporin (12% for Cmax and 27% for AUC0–12). Combination therapy was well tolerated.

Conclusions

There is no clinically meaningful interaction between voclosporin and MMF. As changes in exposure to MPA may affect efficacy and safety, these data confirm that voclosporin and MMF can be administered concomitantly without the need for dose adjustment.
[18F]-FDHT PET/CT as a tool for imaging androgen receptor expression in high-grade glioma
Authors: Orevi Marina , Shamni Ofer , Zalcman Nomi , Chicheportiche Alexandre , Mordechai Anat , Moscovici Samuel , Shoshan Yigal , Shahar Tal , Charbit Hanna , Gutreiman Mijal , Paldor Iddo , Mishani Eyal , Lossos Alexander , Lavon Iris
Published: January 2021

Background

G lioblastoma (GBM) is associated with poor overall survival. Recently, we showed that androgen receptor (AR) protein is overexpressed in 56% of GBM specimens and AR antagonists induced dose-dependent death in several GBM cell lines and significantly reduced tumor growth and prolonged the lifespan of mice implanted with human GBM. 16β-18F-fluoro-5α-dihydrotestosterone ([18F]-FDHT) is a positron emission tomography (PET) tracer used to detect AR expression in prostate and breast cancers. This study was aimed at exploring the ability of [18F]-FDHT-PET to detect AR expression in high-grade gliomas.

Methods

Twelve patients with suspected high-grade glioma underwent a regular workup and additional dynamic and static [18F]-FDHT-PET/CT. Visual and quantitative analyses of [18 F]-FDHT kinetics in the tumor and normal brain were performed. Mean and maximum (max) standardized uptake values (SUVs) were determined in selected volumes of interest. The patients had surgery or biopsy after PET/CT. AR protein was analyzed in the tumor samples by western blot. Fold change in AR expression was calculated by densitometry analysis. Correlation between imaging and AR protein samples was determined.

Results

In six of the 12 patients, [18 F]-FDHT uptake was significantly higher in the tumor than in the normal brain. These patients also had increased AR protein expression within the tumor. Pearson correlation coefficient analysis for the tumor-to-control normal brain uptake ratio in terms of SUVmean versus AR protein expression was positive and significant (R = 0.84; P = .002).

Conclusion

[18 F]-FDHT-PET/CT could identify increased AR expression in high-grade glioma.
Yi-Gang Xu: the Earth's deep interior holds the key to habitability
Authors: Liu By Jin , Mao Ho-Kwang
Published: January 2021

The deep Earth is the engine of whole Earth systems and plays a key role in surface evolution and geological hazards. Scientists have been deciphering the internal processes that shape our habitable planet, especially since the formulation of plate tectonics theory. To date, how the deep Earth works remains mysterious. At the end of 2020, the Chinese Academy of Sciences (CAS) started to set up the Center for Excellence in Deep Earth Science, headquartered in the Guangzhou Institute of Geochemistry (GIG), with long-term support for these emerging and interdisciplinary research areas. NSR recently talked to Professor Yi-Gang Xu, GIG’s Director, about why the study of the Earth's interior is essential, the current progress of deep Earth science in China, and what makes our planet habitable.
Cost-effectiveness of Remdesivir and Dexamethasone for COVID-19 Treatment in South Africa
Authors: Jo Youngji , Jamieson Lise , Edoka Ijeoma , Long Lawrence , Silal Sheetal , Pulliam Juliet R C , Moultrie Harry , Sanne Ian , Meyer-Rath Gesine , Nichols Brooke E
Published: January 2021

Background

Dexamethasone and remdesivir have the potential to reduce coronavirus disease 2019 (COVID)–related mortality or recovery time, but their cost-effectiveness in countries with limited intensive care resources is unknown.

Methods

We projected intensive care unit (ICU) needs and capacity from August 2020 to January 2021 using the South African National COVID-19 Epi Model. We assessed the cost-effectiveness of (1) administration of dexamethasone to ventilated patients and remdesivir to nonventilated patients, (2) dexamethasone alone to both nonventilated and ventilated patients, (3) remdesivir to nonventilated patients only, and (4) dexamethasone to ventilated patients only, all relative to a scenario of standard care. We estimated costs from the health care system perspective in 2020 US dollars, deaths averted, and the incremental cost-effectiveness ratios of each scenario.

Results

Remdesivir for nonventilated patients and dexamethasone for ventilated patients was estimated to result in 408 (uncertainty range, 229–1891) deaths averted (assuming no efficacy [uncertainty range, 0%–70%] of remdesivir) compared with standard care and to save $15 million. This result was driven by the efficacy of dexamethasone and the reduction of ICU-time required for patients treated with remdesivir. The scenario of dexamethasone alone for nonventilated and ventilated patients requires an additional $159 000 and averts 689 [uncertainty range, 330–1118] deaths, resulting in $231 per death averted, relative to standard care.

Conclusions

The use of remdesivir for nonventilated patients and dexamethasone for ventilated patients is likely to be cost-saving compared with standard care by reducing ICU days. Further efforts to improve recovery time with remdesivir and dexamethasone in ICUs could save lives and costs in South Africa.
Infrarenal inferior vena cava agenesis and recurrent deep vein thrombosis: a case report and literature review
Authors: Prado Victor E , Rey-Mendoza Juan Pablo , Wakefield Connor J , Aqeel Sheeba Ba , Kumssa Admasu
Published: January 2021

Inferior vena cava agenesis is a rare congenital vascular defect often diagnosed as an incidental finding in asymptomatic patients. When symptoms arise, it can present with chronic venous stasis or unprovoked deep vein thrombosis (DVT).

A 42-year-old man with history of unprovoked right lower extremity (RLE) DVTs was admitted for swelling, pain and erythema to the RLE, concerning for new DVT. Venous Doppler ultrasound showed a chronic DVT of the right proximal femoral vein in addition to an acute DVT of the distal femoral vein. Extensive thrombophilia workup was negative and additional imaging with abdominal computed tomography scan revealed the absence of the infrarenal inferior vena cava. Patient was treated with oral anticoagulation and compression stockings and discharged with clinical improvement. At 3-month follow-up, patient was completely asymptomatic.

Recurrent unprovoked DVTs in young patients require exhaustive work up including imaging studies to rule out vascular anomalies.
Wide complex tachycardia in a patient with COVID-19 treated with chloroquine/azithromycin
Authors: Gracia-Ramos Abraham Edgar , Cortes-Ortiz Antonio
Published: January 2021

Azithromycin and chloroquine/hydroxychloroquine are being used internationally off-label to treat patients with coronavirus disease 2019 (COVID-19) based on in vitro and weak studies involving humans. However, the evidence about the benefit of these drugs is very uncertain and on the other hand, information regarding possible harms is on the rise. There are increasing reports associating chloroquine/hydroxychloroquine with/without azithromycin with prolonged QT and ventricular arrhythmias (monomorphic or polymorphic ventricular tachycardia) in COVID-19 patients. We present the case of a severe acute respiratory syndrome coronavirus 2-infected kidney transplant patient for which he received treatment with chloroquine plus azithromycin and on Day 4 of therapy, the patient suddenly developed a wide complex tachycardia. Because of the increasing reports of adverse effects related to these drugs, their use should be avoided until further evidence of clinical benefit is available.
An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect
Authors: Mohammad Lava , Doya Leen , Omran Razan , Ibrahim Alexander , Alshehabi Zuheir , Ibrahim Ali
Published: January 2021

Isoniazid (INH) is highly bactericidal against replicating tubercule bacilli and is involved in all antituberculous chemotherapeutic regimens. Several neurological adverse effects, following both therapeutic and overdose use of INH, have been reported in adults in the literature. Here, we present a case of a 5-year-old girl with intestinal Tuberculosis, who developed hemiclonic seizure as a side effect of INH therapeutic dose after 2 weeks of tuberculosis therapy.
Hyponatremia caused by water intoxication: successful treatment of psychiatric disturbances with olanzapine and fluoxetine
Authors: Taube Maris
Published: January 2021

Hyponatremia is a frequent, yet often unrecognized result of water intoxication caused by psychogenic polydipsia in patients with psychiatric disorders such as schizophrenia and anorexia nervosa. The consequences of hyponatremia may include cerebral edema with tonic–clonic seizures and, in extreme cases, death. In cases of hyponatremia seen in psychiatric practices, the use of psychotropic drugs is often necessary to address both the underlying psychiatric problem and reduce the hyponatremia. Therefore, a patient’s clinical condition, the risk of side effects, the possible effect of the medication on hyponatremia and a history of prior medication use should be considered when selecting appropriate psychotropics. The present clinical case details the beneficial effects of olanzapine and fluoxetine in treating a patient with anorexia nervosa and body dysmorphic disorder experiencing acute hyponatremia, and the stable effect the medications achieved over a period of 2.5 years of maintenance therapy.
Pheochromocytoma induced cardiomyopathy in a young man: a case report
Authors: Zörner Christopher Ryan , Dixen Ulrik , Toft Birgitte Grønkær , Ynddal Mie Skjøttgaard , Sommer Peter , Hove Jens Dahlgaard , Frydland Martin Steen
Published: January 2021

Pheochromocytoma is a tumor arising from the adrenal medulla, most frequent benign and, due to the excretion of catecholamines, a rare cause of hypertension. The diagnosis of pheochromocytoma can be challenging because of its episodic nature, unspecific symptoms and rarity. Consequently, treatment can be delayed with serious consequences for the patient. We present a case report regarding a young man with episodes of severe hypertension over a period of at least 9 years. Ultimately, with a possible trigger effect from the intake of multiple energy drinks, the patient presented with severe hypertension, symptoms mimicking acute coronary syndrome, abnormal laboratory parameters and echocardiography suggestive of severe cardiomyopathy. The patient’s pheochromocytoma was incidentally identified in a computed tomography scan during the initial workup. Although a rare condition, pheochromocytoma should be considered as a differential diagnosis, especially in young patients presenting with unexplained hypertension, chest pain and cardiac dysfunction.
A case of hypereosinophilic syndrome with STAT5b N642H mutation
Authors: Ding Feihong , Wu Chaoping , Li Yun , Mukherjee Sudipto , Ghosh Subha , Arrossi A Valeria , Krishnan Sudhir
Published: January 2021

Hypereosinophilia is defined as persistent eosinophilia (>1.5 × 109/L). Hypereosinophilic syndrome (HES) is a term used to describe a group of disorders characterized by sustained hypereosinophilia associated with end-organ damage. Based on underlying molecular mechanism of eosinophilia, there are different subtypes of HES. Diagnosis of HES subtype can be challenging, especially in the absence of overt lymphoid/myeloid neoplasms or discernable secondary causes. Long-term outpatient follow-up with periodic complete blood count and repeated bone marrow biopsy may be needed to monitor disease activity. Somatic signal transducer and activation transcription 5b (STAT5b) N642H mutation was recently found to be associated with myeloid neoplasms with eosinophilia. We report a case of HES who presented with pulmonary embolism and acute eosinophilic pneumonia, found to have recurrent STAT5b N642H mutation by next-generation sequencing, suggesting possible underlying myeloid neoplasm.
Prima Donna
Authors: Wink Paul
Published: January 2021

Prima Donna: The Psychology of Maria Callas explores the psychological mechanisms behind the hypnotic power of Callas’s artistry and her tragic life story. Advances in developmental psychology and the concept of narcissism are used to shed light on Callas’s puzzling personal deterioration during the last nine years of her life. Although precipitated by the trauma and shame over being abandoned by Aristotle Onassis and the precipitous deterioration of her voice, Callas midlife disintegration reflects deeper psychological vulnerabilities. Throughout her life, Callas’s lingering view that her career had been imposed upon her and that her mother compelled her to sing professionally led to her ambivalent relationship with the world of opera. Callas’s sense of superiority, derived from being celebrated for her special talent, coincided with feelings of vulnerability and inferiority embedded in her realization that she was celebrated not for her intrinsic worth but for her exceptional talent. Lacking a cohesive and integrated sense of self, she sought affirmation and vitality from merger with adoring audiences and older men, including her husband Battista Meneghini and her long-term partner Onassis. The propensity to fuse her identity with stage roles contributed to her artistic greatness, but envy and the lack of an intrinsic sense of meaning and worth enhanced her vulnerability to life’s vagaries.
Elevated temperature results in higher compositional variability of pioneer phytoplankton communities in a mesocosm system
Authors: Pálffy Károly , Kovács Attila W , Kardos Vivien , Hausz Imola , Boros Gergely
Published: January 2021

A crucial point in current research on plankton ecology is how global warming will change community functioning, which has led to numerous studies addressing the question with a variety of conclusions. We previously observed a long-term increase in the compositional variability of phytoplankton in a large shallow lake with a concurrent rise in mean temperature, and we conducted an experimental test of this hypothetical link in a mesocosm system. Following predictions of water temperature for the end of the century, 12 mesocosms were filled with prefiltered and sterilized lake water with six of the tanks kept 3°C above ambient levels. Phytoplankton colonization and subsequent changes in its composition were monitored using microscopic analysis and flow cytometry. Chlorophytes were the most successful colonizers, with no treatment-specific effect on dominant taxa. However, heated mesocosms showed higher variation in community structure (distance-based beta diversity), due to higher variability in subdominant species, a considerable portion of which were flagellated taxa. Our hypothesis of temperature-driven compositional variation was supported by both cytometric and taxonomic data, implying that higher spring temperatures can enhance variability in phytoplankton, which might increase the chance of alternate pathways during succession and reduce the predictability of its annual cycle.
Temporal Association of Pain Catastrophizing and Pain Severity Across the Perioperative Period: A Cross-Lagged Panel Analysis After Total Knee Arthroplasty
Authors: Speed Traci J , Jung Mun Chung , Smith Michael T , Khanuja Harpal S , Sterling Robert S , Letzen Janelle E , Haythornthwaite Jennifer A , Edwards Robert R , Campbell Claudia M
Published: January 2021

Objective

Although numerous studies show that preoperative pain catastrophizing is a risk factor for pain after total knee arthroplasty (TKA), little is known about the temporal course of the association between perioperative pain catastrophizing and pain severity. The present study investigated temporal changes and their dynamic associations between pain catastrophizing and pain severity before and after TKA.

Design

A secondary data analysis of a larger observational parent study featuring prospective repeated measurement over 12 months.

Setting

Dual-site academic hospital.

Subjects

A total of 245 individuals who underwent TKA.

Methods

Participants completed pain catastrophizing and pain severity questionnaires at baseline, 6 weeks, and 3, 6, and 12 months after TKA. Cross-lagged panel analysis was conducted with structural equation modeling including age, sex, race, baseline anxiety, and depressive symptoms as covariates.

Results

Reduction in pain catastrophizing from baseline to 6 weeks after TKA was associated with lower pain severity at 3 months after TKA (standardized β = 0.14; SE = 0.07, P = 0.046), while reduction in pain severity at 6 weeks after TKA was not associated with pain catastrophizing at 3 months after TKA (P = 0.905). In the chronic postsurgical period (>3 months), pain catastrophizing at 6 months after TKA predicted pain severity at 12 months after TKA (β = 0.23, P = 0.009) with controlling for auto-correlation and covariates, but not vice versa.

Conclusions

We provide evidence that changes in pain catastrophizing from baseline to 6 weeks after TKA are associated with subsequent pain severity. Future studies are warranted to determine whether targeting pain catastrophizing during the perioperative period may improve clinical outcomes for individuals undergoing TKA.
Coping strategies and physical health in police units dealing with serious crime: Does work experience count?
Authors: Pavšič Mrevlje Tinkara , Erčulj Vanja I
Published: January 2021

Police work is stressful and can lead to absenteeism, withdrawal, and impaired physical health. However, the stress brought by work can be reduced by effective coping strategies. The aim of our study is to explore the relationship between health and coping strategies of officers in three different units dealing with serious crime (homicide and sexual offences, juvenile crime, and crime scene investigation). The moderating role of work experience in this relationship is also explored. We used the Coping Responses Inventory questionnaire to assess coping strategies and the Pennebaker Inventory of Limbic Languidness to measure physical symptoms. Overall, the sample included 104 respondents. The approach coping strategies prevail among all three units. However, avoidance-coping strategy use is associated with more frequent somatic symptoms (P= 0.005). These are particularly linked to the emotional discharge (P < 0.001), especially in the group of officers with longer years of service (P = 0.01). Still, when this strategy is used rarely or not at all, more experienced officers report fewer symptoms than their younger colleagues. Preventive programmes promoting adaptive coping strategies would benefit police officers since avoidance-coping strategies are linked to more frequent physical symptomatology. More experienced police officers with somatic complaints should be focused on in particular.
Solidarity as a companion virtue in response to the COVID-19 pandemic
Authors: Galang Joseph Renus F , Gopez Jose Ma W , Capulong Harvey Gain M , Gozum Ivan Efreaim A
Published: January 2021

This paper establishes that there is a need to turn to virtue ethics in dealing with the COVID-19 pandemic. It argues that the virtue of solidarity can be a companion virtue to compassion for medical frontline workers and other individuals involved. Like compassion, the virtue of solidarity is a reminder that everyone is in this crisis together and that each is responsible for all.
Common good and public service as vital components for government officials in promoting COVID-19 vaccination
Authors: Gozum Ivan Efreaim A
Published: January 2021

Recent reports show that there is resistance in certain countries in regard with receiving COVID-19 vaccination. Different factors contribute to this resistance. With this, if we are to promote COVID-19 vaccination, government officials must build public trust so that the hesitancy among the citizens will be lessened. Thus, this paper proposes that in building public trust, the true essence of common good and public service must be seen from the officials so that their constituents will trust them with their decisions.
Skilled Labor Mobility and Firm Value: Evidence from Green Card Allocations
Authors: Shen Mo
Published: January 2021

This paper studies how the labor market frictions of skilled workers affect corporate valuation. The analysis features immigrant workers’ mobility constraints imposed by the U.S. green card application process and exploits exogenous variations caused by imperfections in the current immigration system. The study finds that relaxing mobility constraints negatively influences firm value. This effect is stronger for firms with higher labor adjustment costs. Reductions in investments and increases in labor costs are channels through which labor mobility adversely affects firm value. The findings suggest that monopoly rent over skilled workers is an important economic determinant of corporate valuation.
Reconsidering Returns
Authors: Hartzmark Samuel M , Solomon David H
Published: January 2021

Investors’ perception of performance is biased because the relevant measure, returns, is rarely displayed. Major indices ignore dividends, thereby underreporting market performance. Newspapers are more pessimistic on ex-dividend days, consistent with mistaking the index for returns. Market betas should track returns, but track prices more than dividends, creating predictable returns. Mutual funds receive inflows for “beating the S&P 500” price index based on net asset value (also not a return). Investors extrapolate market indices, not returns, when forming annual performance expectations. Displaying returns by default would ameliorate these issues, which arise despite high attention and agreement on the appropriate measure.
Capital Flows, Real Estate, and Local Cycles: Evidence from German Cities, Banks, and Firms
Authors: Bednarek Peter , Kaat Daniel Marcel te , Ma Chang , Rebucci Alessandro
Published: January 2021

We study how capital flows affects German cities’ GDP growth depending on the state of their real estate markets. Identification exploits a policy framework assigning refugees to cities on a quasi-random basis and variation in nondevelopable area for the construction of an exposure measure to real estate market tightness. We estimate that the most exposed cities to real estate market tightness grew at least 1.9 percentage points more than the least exposed ones, cumulatively, from 2009 to 2014. Capital inflows shift credit to firms with more collateral, which leads firms to hire and invest more in response to these shocks.
In search of the most reproducible neural vulnerability factors that predict future weight gain: analyses of data from six prospective studies
Authors: Yokum Sonja , Gearhardt Ashley N , Stice Eric
Published: January 2021

We tested if we could replicate the main effect relations of elevated striatum and lateral orbitofrontal cortex (OFC) response to high-calorie food stimuli to weight gain reported in past papers in six prospective datasets that used similar functional MRI (fMRI) paradigms. Participants in Study 1 (N = 37; M (mean) age = 15.5), Study 2 (N = 160; M age = 15.3), Study 3 (N = 130; M age = 15.0), Study 4 (N = 175; M age = 14.3), Study 5 (N = 45; M age = 20.8) and Study 6 (N = 49; M age = 31.1) completed fMRI scans at the baseline and had their body mass index (BMI) and body fat (Studies 4 and 6 only) measured at the baseline and over follow-ups. Elevated striatal response to palatable food images predicted BMI gain in Studies 1 and 6 and body fat gain in Study 6. Lateral OFC activation did not predict weight gain in any of the six studies. The result provide limited support for the hypothesis that elevated reward region responsivity to palatable food images predicts weight gain. Factors that make replication difficult are discussed and potential solutions considered.
Anterior cingulate gyrus acts as a moderator of the relationship between problematic mobile phone use and depressive symptoms in college students
Authors: Zou Liwei , Wu Xiaoyan , Tao Shuman , Yang Yajuan , Zhang Qingjun , Hong Xuedong , Xie Yang , Li Tingting , Zheng Suisheng , Tao Fangbiao
Published: January 2021

This study aimed to investigate the brain grey matter volume (GMV) related to problematic mobile phone use (PMPU), and whether these regions of GMV play a potential moderating role in the relationship between PMPU and depressive symptoms. We recruited 266 students who underwent magnetic resonance imaging (MRI) scanning. PMPU and depressive symptoms were assessed by a self-rating questionnaire for adolescent PMPU and patient health questionnaire-9, respectively. A multiple regression model was performed to detect GMV and white matter (WM) integrity associated with PMPU by voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) methods, and the moderating analysis was conducted by PROCESS using SPSS software. VBM analysis found an inverse correlation between the GMV of the anterior cingulate gyrus (ACC) and right fusiform gyrus (FFG) with PMPU (PFDR < 0.05), and TBSS analysis revealed that fractional anisotropy (FA) in the body of the corpus callosum was negatively correlated with PMPU. The correlation between PMPU and depressive symptoms was moderated by the GMV of the ACC. These results suggest that the GMV of the ACC and right FFG, as well as FA in the body of the corpus callosum, was related to PMPU, and we further found that increased GMV of the ACC could reduce the relationship between PMPU and depressive symptoms in college students.
Stability of nocturnal wake and sleep stages defines central nervous system disorders of hypersomnolence
Authors: Maski Kiran P , Colclasure Alicia , Little Elaina , Steinhart Erin , Scammell Thomas E , Navidi William , Diniz Behn Cecilia
Published: January 2021

Study Objectives

We determine if young people with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH) have distinct nocturnal sleep stability phenotypes compared to subjectively sleepy controls.

Methods

Participants were 5- to 21-year old and drug-naïve or drug free: NT1 (n = 46), NT2 (n = 12), IH (n = 18), and subjectively sleepy controls (n = 48). We compared the following sleep stability measures from polysomnogram recording between each hypersomnolence disorder to subjectively sleepy controls: number of wake and sleep stage bouts, Kaplan–Meier survival curves for wake and sleep stages, and median bout durations.

Results

Compared to the subjectively sleepy control group, NT1 participants had more bouts of wake and all sleep stages (p ≤ .005) except stage N3. NT1 participants had worse survival of nocturnal wake, stage N2, and rapid eye movement (REM) bouts (p < .005). In the first 8 hours of sleep, NT1 participants had longer stage N1 bouts but shorter REM (all ps < .004). IH participants had a similar number of bouts but better survival of stage N2 bouts (p = .001), and shorter stage N3 bouts in the first 8 hours of sleep (p = .003). In contrast, NT2 participants showed better stage N1 bout survival (p = .006) and longer stage N1 bouts (p = .02).

Conclusions

NT1, NT2, and IH have unique sleep physiology compared to subjectively sleepy controls, with only NT1 demonstrating clear nocturnal wake and sleep instability. Overall, sleep stability measures may aid in diagnoses and management of these central nervous system disorders of hypersomnolence.
A biofoundry workflow for the identification of genetic determinants of microbial growth inhibition
Authors: Moffat Alaster D , Elliston Adam , Patron Nicola J , Truman Andrew W , Carrasco Lopez Jose A
Published: January 2021

Biofoundries integrate high-throughput software and hardware platforms with synthetic biology approaches to enable the design, execution and analyses of large-scale experiments. The unique and powerful combination of laboratory infrastructure and expertise in molecular biology and automation programming, provide flexible resources for a wide range of workflows and research areas. Here, we demonstrate the applicability of biofoundries to molecular microbiology, describing the development and application of automated workflows to identify the genetic basis of growth inhibition of the plant pathogen Streptomyces scabies by a Pseudomonas strain isolated from a potato field. Combining transposon mutagenesis with automated high-throughput antagonistic assays, the workflow accelerated the screening of 2880 mutants to correlate growth inhibition with a biosynthetic gene cluster within 2 weeks.