bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential Role of Antibodies Against Aquaporin-1 in Patients with Central Nervous System Demyelination
Authors: Pechlivanidou Maria , Xenou Konstantina , Tzanetakos Dimitrios , Koutsos Emmanuel , Stergiou Christos , Andreadou Elisabeth , Voumvourakis Konstantinos , Giannopoulos Sotirios , Kilidireas Constantinos , Tüzün Erdem , Tsivgoulis Georgios , Tzartos Socrates , Tzartos John
Published: July 2023

Aquaporins (AQPs; AQP0-AQP12) are water channels expressed in many and diverse cell types, participating in various functions of cells, tissues and systems, including the central nervous system (CNS). AQP dysfunction and autoimmunity to AQPs are implicated in several diseases. The best-known example of autoimmunity against AQPs is the antibodies to AQP4 which are involved in the pathogenesis of Neuromyelitis Optica spectrum disorder (NMOSD), a demyelinating disease of the CNS. The present review focuses on the discovery and the potential role of antibodies against AQP1 in the CNS, and their potential involvement in CNS demyelination and specifically in NMOSD. We describe (a) the several techniques developed for the detection of the AQP1-antibodies, with emphasis on methods that specifically identify antibodies targeting the extracellular domain of AQP1, i.e., those of potential pathogenic role, and (b) the available evidence supporting the pathogenic relevance of AQP1-antibodies.
Lateral Spread Response: Unveiling the Smoking Gun for Cured Hemifacial Spasm
Authors: Cho Kyung Rae , Park Sang-Ku , Park Kwan
Published: July 2023

Hemifacial spasm (HFS) is a rare disorder characterized by involuntary facial muscle contractions. The primary cause is mechanical compression of the facial nerve by nearby structures. Lateral spread response (LSR) is an abnormal muscle response observed during electromyogram (EMG) testing and is associated with HFS. Intraoperative monitoring of LSR is crucial during surgery to confirm successful decompression. Proper anesthesia and electrode positioning are important for accurate LSR monitoring. Stimulation parameters should be carefully adjusted to avoid artifacts. The disappearance of LSR during surgery is associated with short-term outcomes, but its persistence does not necessarily indicate poor long-term outcomes. LSR monitoring has both positive and negative prognostic value, and its predictive ability varies across studies. Early disappearance of LSR can occur before decompression and may indicate better clinical outcomes. Further research is needed to fully understand the implications of LSR monitoring in HFS surgery.
A Life-Cycle Carbon Emissions Model for Traditional Residential Houses: Applying to Traditional Dong Dwellings in Qandongnan, Guizhou Province, China
Authors: Wang Sicheng , Guo Yuanyuan , Zhang Hao , Gao Mingming
Published: July 2023

In recent years, due to the low energy utilization of the whole life-cycle of buildings and the di-minished indoor and outdoor comfort of buildings and the impact on the surrounding environ-ment caused by the carbon emissions of the building life-cycle, the establishment of a whole life- cycle carbon emission model for buildings to improve their energy utilization at all stages of their life-cycle has received unprecedented attention. In China, the construction industry has become a major carbon emitter, and traditional houses, as a green development building type, are an effec-tive way to achieve carbon neutrality in buildings, but the existing green building evaluation system lacks quantitative indicators of carbon emissions in the building life-cycle. The exclusive evaluation indexes for regional and characteristic buildings, such as traditional houses, are ne-glected; This study explored the formula for calculating the life-cycle carbon emissions model of traditional residential houses under a carbon emission intervention and used real measurements of the physical environment and comparative analysis of the limitations of existing local stand-ards; The results showed that the carbon emission calculation formulas for each stage of the life-cycle of traditional residential houses must be established by combining the selection of local building materials, and the materials for sustainable energy and carbon sinks of green systems. Based on the results of indoor and outdoor heat and humidity environmental tests of residential houses and an analysis of the limitations of existing evaluation indexes due to locality, four im-portant factors affecting locality green buildings in terms of energy utilization, site ecology and landscape, land saving and material saving were extracted; on this basis, the whole life-cycle carbon emission model of traditional residential houses is constructed by combining the existing green building evaluation standards with the carbon emission indexes of the life-cycle of tradi-tional residential houses.
Mechanistic Elucidation of Activation/Deactivation Signal Transduction within Neurotensin Receptor 1 Triggered by ‘Driver Chemical Groups’ of Modulators: A Comparative Molecular Dynamics Simulation
Authors: Lu Xun , Shi Xinchao , Fan Jigang , Li Mingyu , Zhang Yuxiang , Lu Shaoyong , Xu Guanhuan , Chen Ziqiang
Published: July 2023

Small molecule modulators of neurotensin receptor 1 (NTSR1), a class A G protein-coupled receptor (GPCR), has been emerging as promising therapeutics for psychiatric disorders and cancer. Interestingly, a chemical group substitution of NTSR1 modulators can launch different downstream regulation, highlighting the significance of deciphering the internal fine-tuning mechanism. Here, we conducted synergistic application of Gaussian accelerated molecular dynamics simulation, conventional molecular dynamics simulation, and Markov state models (MSM) to investigate the underpinning mechanism of ‘driver chemical groups’ of modulators triggering inverse signaling. The result indicated that the flexibility of leucine moiety in NTSR1 agonists contributes to the inward displacement of TM7 through a loosely coupled allosteric pathway, while the rigidity of adamantane moiety in NTSR1 antagonists leads to unfavorable downward transduction of agonistic signaling. Furthermore, we found that R3226.54, Y3196.51, F3537.42, R1483.32, S3567.45 and S3577.46 may play a key role in inducing the activation of NTSR1. Together, our findings not only highlight the ingenious signal transduction within class A GPCRs, but also lay a foundation for the development of targeted drugs harboring different regulatory function of NTSR1.
Study of the Metrorrhagia of the First Trimester. Early Pregnancy Loss, Importance of Advanced Maternal Age
Authors: Baños Cándenas Laura , Abehsera Davó Daniel , Castaño Frías Lucía , González Mesa Ernesto
Published: July 2023

Background and Objectives: The purpose of this study was to assess the bleeding that occurs during the first weeks of gestation and its implications throughout pregnancy. Secondarily, we studied the associated complications that appeared and tried to identify possible risk factors that could serve to select women at a greater risk of adverse outcomes that could benefit from an early diagnosis and improved monitoring. Materials and Methods: We selected all the women who consulted for first trimester metrorrhagia in the Emergency Department of the Hospital QuirónSalud in Malaga over the year 2015. We refer to first trimester metrorrhagia as that which occurs until week 12+6. Once the pregnant women were identified, we studied certain risk factors already present prior to the gestation and others associated with the gestation and its evolution. Results: After reviewing the visits to the obstetrics and gynecology emergency department, we selected those patients that met the inclusion criteria, resulting in a sample of 696 patients that we followed up. The average age of our patients was 34.1 years, with an average number of visits to the hospital of 1.67, most of them between the 5th and 8th weeks of pregnancy. 45.3% of these pregnancies resulted in a first trimester miscarriage, mainly between weeks 6 and 8. We tried to establish associations in order to identify possible risk factors, finding a relationship between increased maternal age and a higher risk of first trimester pregnancy loss, which rises as maternal age increases (33,37 4,316 years vs 35,01 4,740 years). This increase in risk is proportional to the increase in age. We made subgroups of women over 35 and over 40 and confirmed that increased age led to worse outcomes. We also studied several gestational complications and concluded that they appeared more frequently among older women. These complications include prematurity (33.11 vs 34.48 years), gestational diabetes (33.11 vs 36.06 years) and preeclampsia (33.25 vs 35 years). We reviewed the obstetric history of pregnant women whose gestation resulted in miscarriage and found that 50.5% of them had previously had another loss. Conclusions: Comparing the results with data from the general population, we found that the rate of first trimester miscarriage is up to 3 times higher among women who present bleeding during the first weeks of gestation compared to those who do not develop this complication. Maternal age is a risk factor for first trimester pregnancy loss and for the development of complications associated with pregnancy.
Red Blood Cells and Endothelium Derived Circulating Extracellular Vesicles in Health and Chronic Heart Failure: A Focus on Phosphatidylserine Dynamics in Vesiculation
Authors: Suades Rosa , Vilella-Figuerola Alba , Padró Teresa , Mirabet Sonia , Badimon Lina
Published: July 2023

Circulating extracellular microvesicles (cEVs) are characterised by presenting surface antigens of parental cells. Since their biogenesis involves the translocation of phosphatidylserine (PS) from the inner to the outer-leaflet of the plasma membrane, exposed PS has been considered as a recognition hallmark of cEVs. However, not all cEVs externalise PS. In this study we have phenotypically and quantitatively characterised cEVs by flow cytometry with special attention to the proportions of PS in chronic heart failure patients (cHF; n=119) and reference non-HF group (n=21). PS─-cEVs were predominantly found in both groups. Parental markers showed differential pattern depending on PS exposure. Endothelium-derived and connexin 43-rich cEVs were mainly PS─-cEVs and significantly increased in cHF. On the contrary, platelet-derived cEVs were mostly PS+ and were increased in non-HF. We observed similar levels of PS+- and PS─-cEVs in non-HF subjects when analysing immune cell-derived EVs, but there was a subset-specific difference in cHF patients. Indeed, those cEVs carrying CD45+, CD29+, CD11b+ and CD15+ were mainly PS+-cEVs, while those carrying CD14+, CD3+ and CD56+ were mainly PS─-cEVs. In conclusion, endothelial and red blood cells are stressed in cHF patients as detected by a high shedding of cEVs. Despite PS+-cEVs and PS─-cEVs represent two distinct cEV populations, their release and potential function as both biomarkers and shuttles for cell communication seem unrelated to PS content.
Resource allocation of 3-PLP LDM system using a Lagrange multiplier method
Authors: Kim Ho Jae , Kwon Soon-Young , Bae JaeHwui , Hur Namho , Kim Hyoung-Nam
Published: July 2023

The increasing amount of data transmitted through digital broadcasting and communication channels requires efficient transmission methods that make the most of limited resources such as frequency, time, and power. The layered division multiplexing (LDM) system, which is adopted by the Advanced Television Systems Committee (ATSC) 3.0 standard, is considered one of a solution for achieving efficient transmission. Additionally, the layered time-division multiplexing (LTDM) and time layered division multiplexing (TLDM) systems have been developed as well. These layered transmission systems, utilizing multiple physical layer pipes (PLPs), offer a wide range of services including mobile and rooftop TV. To compare the efficiencies of different layered transmission systems, the article introduces the concept of normalized channel capacity. This measure allows for a fair comparison among the systems by taking into account the specific channel capacity requirements of each service. By summing the normalized channel capacities, a method is proposed to select the most efficient transmission system among the four systems: LDM, LTDM, TLDM, and time division multiplexing (TDM). The Lagrange multiplier method is employed to find the parameters that maximize the sum of the normalized channel capacities in these systems. Through simulations conducted with the determined parameters, it is demonstrated that the LDM system exhibits the highest efficiency among the four systems.
Insights into the Mechanism of Action of Antipsychotic Drugs Derived from Animal Models: Standard of Care versus Novel Targets
Authors: Grace Anthony A. , Uliana Daniela
Published: July 2023

Therapeutic intervention for schizophrenia relies on blockade of dopamine D2 receptors in the associative striatum; however, there is little evidence for baseline overdrive of the dopamine system. Instead, the dopamine system is in a hyper-responsive state due to excessive drive by the hippocampus. This causes more dopamine neurons to be in a spontaneously active, hyper-responsive state. Antipsychotic drugs alleviate this by causing depolarization block, or excessive depolarization-induced dopamine neuron inactivation. Indeed, both first- and second-generation antipsychotic drugs cause depolarization block in the ventral tegmentum to relieve positive symptoms, whereas first-generation drugs also cause depolarization in the nigrostriatal dopamine system to lead to extrapyramidal side effects. However, by blocking dopamine receptors, these drugs are acting multiple synapses downstream from the proposed site of pathology: the loss of inhibitory influence over the hippocampus. An overactive hippocampus can not only drive the dopamine-dependent positive symptoms, but via its projections to the amygdala and the neocortex could also drive negative and cognitive symptoms, respectively. On this basis, a novel class of drugs that can reverse schizophrenia at the site of pathology, i.e. the hippocampal overdrive, could be effective in alleviating all three classes of symptoms of schizophrenia while also being better tolerated.
Tracking-integrated CPV technology: State-of-the-art and classification
Authors: Ceballos Maria A. , Pérez-Higueras Pedro J. , F. Fernández Eduardo , Almonacid Florencia M.
Published: July 2023

Concentrator photovoltaic (CPV) technology offers an alternative to conventional photovoltaic systems, focusing on the concentration of solar radiation through the optics of the system onto smaller and more efficient solar cells. However, the surface on which the solar beam is incident must remain oriented towards the position of the sun, which requires the use of large and heavy external elements known as solar trackers. In addition to their size, these elements must be as accurate as possible to avoid misalignment. To avoid the need of these solar trackers, the concept of tracking-integrated concentrating systems has been developed. This technology has been researched to make CPV systems accessible in places where conventional systems are not viable, such as building roofs or agrivoltaic fields. This review presents a detailed classification of the existing designs in the literature and providing an overview of this type of system. By eliminating the need for external solar trackers, tracking-integrated CPV systems offer a promising solution to increase the adoption of this technology. Therefore, it is expected that these systems will be a viable and effective option for solar power generation.
An Atypical Presentation of Superficial Breast Cancer: A Case Report and Review of the Literature
Authors: Izzo Paolo , Izzo Luciano , Polistena Andrea , Sibio Simone , Codacci-Pisanelli Massimo , Crocetti Daniele , Gabriele Raimondo , De Intinis Claudia , Izzo Sara
Published: July 2023

(1) Background: Retroareolar breast tumors, although common, rarely develop into malignancies. This case report presents the case of a 54-year-old woman with a superficial breast tumor, high-lighting the significance of considering a wide range of possibilities when evaluating breast lumps. (2) Methods: The patient presented with a progressively enlarging, ulcerating superficial mass in her left breast. To determine the nature of the tumor and results confirmed the presence of a Grade II superficial infiltrating ductal carcinoma. To address the condition, the patient un-derwent a modified radical mastectomy under general anesthesia. Following the surgery, she was prescribed tamoxifen, an estrogen receptor modulator, in accordance with the current guidelines. (3) Results: The patient experienced a smooth recovery without any complications and displayed no signs of recurrence or metastasis during follow-up visits. This positive outcome highlights the importance of early detection and proactive management in improving patient prognosis. (4) Conclusions: This case report underscores the significance of conducting a comprehensive ex-amination and maintaining a high index of suspicion for breast lumps. This report contributes to the existing body of literature on the diverse presentations of breast cancer.
APE-1/Ref-1 Inhibition Blocks Malignant Pleural Mesothelioma Cell Proliferation and Invasiveness: A Crosstalk between Oxidative Stress and Epithelial Mesenchymal Transition (EMT) in Driving Carcinogenesis and Metastasis
Authors: Ramundo Valeria , Zanirato Giada , Palazzo Maria Luisa , Riganti Chiara , Aldieri Elisabetta
Published: July 2023

Malignant Pleural Mesothelioma (MPM) is an aggressive cancer associated to asbestos exposure. MPM pathogenesis has been related both to oxidative stress, evoked by and in response to asbestos fibers exposure, and the Epithelial Mesenchymal Transition (EMT), an event induced by oxidative stress itself and related to cancer proliferation and metastasis. Asbestos related primary oxidative damage is counteracted in the lung by various redox-sensitive factors, often hyperactivated in some cancers. Among these redox-sensitive factors, Apurinic-apyrimidinic endonuclease 1 (APE-1)/Redox effector factor 1 (Ref-1) has been demonstrated to be overexpressed in MPM and lung cancer, but the molecular mechanism has not yet fully understood. Moreover, asbestos exposure has been associated to induced EMT event, via some EMT transcription factors, such as Twist, Zeb-1 and Snail-1, in a possible crosstalk with oxidative stress and inflammation events. To demonstrate this hypothesis, we inhibited/silenced Ref-1 in MPM cells: as a consequence, both EMT (Twist, Zeb-1 and Snail-1) markers and cellular migration/proliferation were significantly inhibited. Take as a whole, these results show, for the first time, a crosstalk between oxidative stress and EMT in MPM carcinogenesis and invasiveness, so improving the knowledge to better address a preventive and therapeutic approach against this aggressive cancer.
Plasma Polymerized Organosilicon Thin Films for Volatile Organic Compounds (VOCs) Detection
Authors: DAKROUB Ghadi , DUGUET Thomas , LACAZE-DUFAURE Corinne , ROUALDES Stéphanie , Van der LEE Arie , REBISCOUL Diane , ROUESSAC Vincent
Published: July 2023

Plasma polymerized (PP) thin films deposited in a soft or intermediate plasma discharge from hexamethyldisiloxane (HMDSO) were developed as sensors for the detection of volatile organic compounds (VOCs) vapors. Energy dispersive X-ray spectroscopy (EDX) and X-ray reflectometry (XRR) were performed to determine the organosilicon films elemental composition and density. Spectroscopic ellipsometry measurements were carried out to determine the refractive index of the films. Quartz crystal microbalance (QCM) and ellipsometry coupled to vapor sorption were used to investigate the sorption mechanism of several VOCs vapors into the films as a function of the plasma deposition conditions. The density and the refractive index of the PP-HMDSO films increased with the plasma energy due to a different chemical composition and different proportion of free volumes in the material network. The PP-HMDSO films showed different affinities towards the VOCs vapors depending on the plasma discharge energy. The films elaborated in the lowest plasma energy revealed a good sensitivity towards the VOCs especially toluene (one of the BTEX vapors) compared to the other films deposited under higher plasma energy. In addition, the selectivity between toluene and other non-BTEX VOCs such as heptane and ethanol decreased to become zero while increasing the plasma energy.
Seroprevalence Study of Brucellosis in Wild Boars Hunted for Private Consumption in Northeast Portugal
Authors: Ruano Zita Martins , Mateus Teresa L. , Chorense Ana , Santos-Silva Sergio , Vieira-Pinto Madalena
Published: July 2023

Brucellosis is an important infectious disease caused by bacteria of the genus Brucella. In the northeast region of Portugal, brucellosis is endemic in small ruminants, and there are also human cases. However, the epidemiological role of the wild boar in the dynamics of this disease in this region is unknown. For this reason, a total of 332 blood samples were collected from wild boar hunted in thirty-six hunting areas during the 2022/2023 hunting season. All were taken by the hunters for private consumption, with no evisceration and examination in the field. Serum sam-ples were tested by i-ELISA. It was observed that 88 wild boars were exposed to Brucella spp., pointing to a seroprevalence of 26.5% (95% CI: 21.8% – 31.3%). This high prevalence underlines the importance that wild boar may have in the dynamics of this disease in the region and its po-tential transmission to other animals and to human, for example, during the handling of carcasses. Increased awareness and knowledge of brucellosis in wild boar is essential for the implementation of effective practices and habits and, consequently, for the control and prevention of this important zoonosis.
Examining the pro-self and prosocial components of a calling outlook: A critical review
Authors: Hart Rona , Hart Dan
Published: July 2023

Work on callings has burgeoned in the past 20 years, yet recent reviews exposed a lack of conceptual clarity and disagreements around its definition, components and measures. One lingering point of contention revolves around the element of prosociality: Is a calling orientation primarily motivated by self-interest, prosocially orientated, or a mix of both? This conceptual paper reviews and examines the pro-self and prosocial component of a calling outlook, by examining and comparing the ways in which they feature in different calling subtypes: Classic, neoclassic, and modern callings. Our analysis suggests that these subtypes vary in where they are located on a pro-self – prosocial continuum: Classic callings are located on the prosocial side of the axis, modern callings are located on pro-self side of the axis, and neoclassic callings can be situated in the middle of the con-tinuum, integrating self-orientated and other-orientated motivations. Our analysis further suggests that these calling subtypes draw on divergent value systems: Classic callings are propelled by self-transcendent values, modern callings are driven by self-actualization motivations, and neoclassic callings integrate both value systems. We therefore argue that the subjective experiences of pursuing a calling within each subtype pathway differ, alt-hough they may culminate in similar outcomes. The paper offers a novel framework for analyzing people’s calling that draws on their values.
May Nutritional Status Positively Affect Disease Progression and Prognosis in Patients with Oesophageal and Pharyngeal Cancers? A Scoping Review of the Current Clinical Studies
Authors: Psara Evmorfia , Papadopoulou Sousana K. , Tryfonos Christina , Tolia Maria , Pandi Aimilia-Lynn , Spanoudaki Maria , Pavlidou Eleni , Tsoukalas Nikolaos , Mentzelou Maria , Giaginis Constantinos
Published: July 2023

Background: Malnutrition in oesophageal and pharyngeal cancer patients constitutes a common and serious concern, which significantly reduces patients’ prognosis. Cancers of the oesophagus and the pharynx can considerably impair feeding in patients, resulting in severe undernutrition. This is a scoping review which aims to critically summarize and scrutinize the current clinical evidence on the use and prognostic role of diverse nutritional assessment tools on the prognosis of patients with oesophageal and pharyngeal cancers. Methods: PubMed, Scopus, Web of Science and Google Scholar databases were comprehensively explored utilizing relative keywords to detect clinical studies that investigate whether nutritional status may affect disease prognosis. Results: Several assessment tools have evaluated and highlighted the prognostic role of nutritional status on patients’ survival and disease complications in both oesophageal and pharyngeal cancers. Regarding oesophageal cancer, CONUT, PNI, PG-SGA and NRS-2002 are more commonly used, while albumin is also frequently evaluated. Regarding pharyngeal cancers, fewer studies are currently available. PNI has been evaluated and its significance as a factor for shorter overall survival, distant metastasis-free survival, progression-free survival, and locoregional recurrence-free has been highlighted. Comprehensive Nutritional Index has also been evaluated with positive results, as well as NRS 2002, GPS, and body weight status. However, there is currently a lack of studies with adequate female patients. There is also a significant lack of well-designed prospective studies with well-organized methodology. Conclusion: Nutritional status may significantly affect disease progression and patients’ survival, highlighting the importance of a good nutritional status in patients with oesophageal and pharyngeal cancers. Further large-scaled and well-designed prospective clinical studies are strongly recommended to verify the potential beneficial effects of nutritional status in patients with oesophageal and pharyngeal cancers.
New Trends to Treat Muscular Atrophy: Systematic Review
Authors: German Iris Jasmin Santos , Torres Karina , Andreo Jesus Carlos , Shindo Joao , Dallantonia Camila , Haber Luiza , Detregiachi Cláudia Rucco Penteado , Araujo Adriano , Guiguer Elen Landgraf , Girio Raul , Bueno Patricia , Souza Maricelma , Rocha Marcia , Barbalho Sandra Maria , Shinohara Andre
Published: July 2023

Epicatechin has been described as a polyphenol compound that promotes skeletal muscle restructuring, by expressing muscle regulation factors, activation of satellite cells and modulation of the main pathways associated with catabolism. However, the literature shows contrasting results of therapeutic effects and treatment protocols. Thus, the aim of this systematic review was to analyze the current literature addressing the molecular mechanism and clinical protocol of epicatechin on skeletal muscular atrophy in humans and animals. A search was conducted in PubMed/MEDLINE, Embase, Web of Science, and Cochrane Library databases. The qualitative analysis showed a prevalence of the inhibitory action of epicatechin in myostatin expression and atrogenes FOXO, MAFbx and MuRF1. Epicatechin showed positive effects on increased follistatin and on the activation of the myogenic regulatory factors (Myf5, MyoD and myogenin). In addition, the studies evidenced the impact of epicatechin on the mitochondrias' biosynthesis in muscle fibers, activation of the signaling pathway of AKT/mTOR protein synthesis, and improvement of skeletal musculature performance, particularly when associated with physical training. Epicatechin showed promising clinical applicability through beneficial results under conditions that negatively affect the skeletal musculature. However, there is no protocol standardization allowing to draw more specific conclusions on its therapeutic use.
Water in the Belly- a Review of Current Knowledge About Ascites in Children
Authors: Kamińska Aleksandra , Plata-Nazar Katarzyna , Leszkowicz Julia
Published: July 2023

Ascites is a term that describes a pathological accumulation of fluid in a peritoneal cavity. It is generally a rare occurrence in a pediatric population and is most commonly associated with liver failure and cirrhosis. In that case, a diuretic treatment is usually implemented to relieve the ascites as it forms in the mechanism of water retention and water leakage from the portal venous system due to portal hypertension. It is important to note however that many other issues may cause ascites in children. Those require a catered approach suited to the pathomechanism of ascites formation in those underlying conditions. That is why a complex diagnostic process ought to be run in pediatric patients with ascites to correctly identify a condition causing it and provide the patient with adequate and thorough care.
Type1 Diabetes and COVID-19: A Systematic Review and Possible Management
Authors: Kashfi Kebria , Anbardar Narges , Asadipooya Artin , Asadipooya Kamyar
Published: July 2023

Introduction SARS-CoV-2 infection normally damages respiratory system but may likewise impair endocrine organs’ function. Thyroid dysfunction and hyperglycemia are common endocrine complications of SARS-CoV-2 infection. Onset of T1D and associated complications including DKA, hospitalization and death, are thought to be increased during the COVID-19 pandemic. The aim of this study is to review the available data about the incidence rate of T1D and accompanying complications since the beginning of the COVID-19 pandemic.
Methods: A systematic review was conducted using electronic databases PubMed and Google Scholar. The keywords “T1D, T1DM, Type 1 DM or Type 1 Diabetes”, “Coronavirus, SARS-CoV-2 or COVID-19” were used to search these databases. Titles and abstracts were screened for selection, and then relevant studies were reviewed in full text.
Result: we selected 21 manuscripts out of 296 identified studies. Data about the incidence rate of T1D, hospitalization and death are not consistent across countries, but DKA incidence and severity seem to be higher during the COVID-19 pandemic.
Conclusion: Our data collection demonstrated that COVID-19 may or may not increase the incidence of type 1 diabetes. Nevertheless, it is associated with higher incidence and severity of DKA in T1D patients. Antivirals are not fully protective against endocrine complications of SARS-CoV-2 infection. Combining medications that reduce SARS-CoV-2 entry into the cells and modulate the immune response to infection is an alternative practical approach to treating COVID-19.
Investigation of Seasonal variation of Fatty Acid and Mineral concentrations of Pecorino Romano PDO cheese: imputation of missing values for enhanced classification and metabolic profile reconstruction
Authors: Sibono Leonardo , Grosso Massimiliano , Tronci Stefania , Errico Massimiliano , Addis Margherita , Vacca Monica , Manis Cristina , Caboni Pierluigi
Published: July 2023

The seasonal variation in fatty acids and minerals concentrations was investigated through the analysis of Pecorino Romano cheese samples collected in January, April, and June. A fraction of samples contained missing values in their fatty acid profile. Probabilistic Principal component analysis coupled with Linear Discriminant Analysis was employed to classify cheese samples on a production season basis while accounting for missing data and quantifying the missing Fatty acids concentration for the sample in which they were absent. The levels of rumenic acid, vac-cenic acid and omega-3 compounds were positively correlated with the spring season, while the length of the saturated fatty acids increased throughout the production seasons. Concerning the classification performances, the optimal number of principal components (i.e., 5) achieved an ac-curacy in cross-validation equal to 98 %. Then, when the model was tasked to impute the lacking Fatty acid concentration values, the optimal number of principal components resulted in an R2 value in cross-validation of 99.53%
THE IMPACT OF THE CROSS-BORDER CULTURAL PHENOMENON OF THE KOREAN WAVE ON CULTURAL TRANSFORMATION IN SAUDI ARABIA
Authors: Abdullah Abdullah , Ubaidillah Ismail
Published: July 2023

Globalization’s impact on culture is vividly apparent in the infiltration of foreign cultures into different countries, as exemplified by the permeation of the Korean Wave, or “Hallyu,” in Saudi Arabia. Among the Saudi youth, Korean TV dramas (K-dramas) and Korean Pop Music (K-POP) have experienced immense popularity, marking a significant shift in traditional ideological, political, and economic boundaries. This cultural shift facilitates an enhanced exchange between Korea and Saudi Arabia, igniting a newfound interest in the Korean language and culture. Concurrently, Korean fashion and beauty trends have seized the attention of Saudi Arabian youth, influencing their clothing, hairstyling, and beauty routines. This research aims to unravel the extent of influence and transformation instigated by such transnational cultural phenomena on local cultures. Utilizing a qualitative approach, this study conducts a literature review to explore the depth and breadth of the Korean Wave’s impact on Saudi Arabian society. Researchers face particular challenges, including limited research availability, language and cultural context, and the reliability of available data. However, despite these constraints, the study provides valuable insights into cultural globalization, media influence, and the dynamics of cross-cultural interactions, advancing our understanding of this evolving global landscape.
TRIAL RITUALS IN MOROCCO: ATTEMPTING TO UNDERSTAND THE REPRESENTATIONS AND EXPLICITNESS OF MODERNISATION CHOICES
Authors: Hatim Anouar
Published: July 2023

This research aims to retrace and interpret the symbolic representations of trial rituals inherited from colonial times in North African countries, attempting to recycle them and make them more compatible with the principles of justice and fairness on which each trial is based. To this end, the researcher used a qualitative descriptive approach, which involved presenting the research problem, collecting the relevant data and analysing it before drawing conclusions. The research has produced several findings, the most important of which is that the symbolic framework of the trial, while helping to present the authority and legitimacy of justice, is in contrast to the values of justice, fairness and equality between the adversaries. It tends to condemn the still innocent accused, even practising intentional violence and ritually contaminating his identity by the insinuations and innuendoes it practices.
Improving the Competence of the Gymnastics Trainer of the Healthy Heart Club in Surakarta about Fitness Exercise Exercise Program
Authors: Riyadi Slamet , Waluyo Waluyo , Utomo Tri Aprilijanto , Sarjoko Sarjoko
Published: July 2023

Community service is the implementation of a fitness exercise program for the Surakarta Healthy Heart Club gymnastics trainer during the covid-19 pandemic. This activity was carried out considering the important role of a healthy heart exercise trainer in an effort to nourish and improve people's fitness so that they have good endurance and avoid transmission of the corona virus. A trainer must have sufficient competence, knowledge and training skills to successfully carry out the vision and mission of the Indonesian Heart Foundation. In connection with the above, the purpose of this activity is to equip trainers with competence, knowledge and training skills for trainers of healthy heart club gymnastics in Surakarta. The materials provided to the gymnastics trainers include training in the preparation of exercise programs, fitness exercise materials, mentoring in the implementation of training during the COVID-19 pandemic and evaluation of physical fitness. The methods used in this activity are: 1) Exposure and discussion of physical fitness material, 2) Demonstration and practice for skills material, namely the practice of compiling an exercise program, practicing fitness and coaching practice with mentoring during P2M. This material is important and urgent to be given to the coach of the Surakarta Healthy Heart Club considering the current situation and conditions, namely the increasingly outbreak of the Covid-19 pandemic in Surakarta and its surroundings.
Physical fitness level of fifth grade students at Centong Elementary School, Gondang District, Mojokerto Regency in the new normal era
Authors: Hasmara Puguh Satya , Ma'arif Ilmul
Published: July 2023

This study aims to determine the level of physical fitness of students in the new noemal era. This research is a quantitative survey method with the aim of describing. The subjects in this study were the fifth grade students of SDN Centong, Gondang District, Mojokerto Regency, amounting to 34 students. The data analysis technique used descriptive statistics using percentages. The instrument used is the Indonesian Physical Fitness Test (TKJI), which consists of 5 test items, namely the 40-meter running test, the hanging elbow test, the 30-second lying down test, the upright jump test, and the last is the 600-meter endurance test. The results of this study are the level of physical fitness of 5th grade SDN Centong students in the medium category with the average cumulative score obtained by students is 16.
The Effect of Industrial Work Practices and Vocational Competencies on Work Readiness by Mediation of Self-Efficacy in Class XII Students of Accounting Skills Competence at South Jakarta State Vocational High School
Authors: Pitaloka Nadya , Sumiati Ati , Respati Dwi Kismayanti
Published: July 2023

This research was conducted with the aim of knowing the effect of industrial work practice, vocational competence, and self-efficacy on job readiness and the effect of industrial work practice and vocational competence on job readiness through self-efficacy in Class XII students of Accounting Skills Competence at the South Jakarta State Vocational High School. This research is a quantitative research with survey method. The population used is 174 with a sample of 114 students. The data analysis technique used is influence analysis or path analysis through the SPSS 24 program. The research results obtained, namely there is a positive and significant influence on industrial work practices, vocational competence, and self-efficacy on job readiness partially, and there is a positive and significant influence on practice industrial work on job readiness through self-efficacy and vocational competence on job readiness through self-efficacy.
The Other Side of the Coin: An Analysis by Turkish Public Relations Professionals on the Qualifications of Public Relations Academics and Curricula
Authors: Oksuz Burcu , Gorpe Tevhide Serra
Published: July 2023

This study aims to investigate the opinions and perceptions of senior Turkish public relations practitioners on the knowledge, skills, competencies, and personal attributes of public relations academics and public relations curriculums. A total of 20 semi-structured interviews were conducted with public relations practitioners working in corporations or consultancies. Results show that the top knowledge areas for public relations practitioners include sociology, psychology, and communication, the most prominent skills include communication skills, IT skills, and visioning, the most important personal attributes include good image, sensitivity/humanity, and life-long learner, and the top competencies are performing and creating. Practical knowledge is as important as theoretical knowledge. Public relations professionals have respect for public relations academics, appreciate their input, but they suggest that the public relations curriculum should be improved and that the graduates should be better informed. This paper also reveals how a dialogue can be established between Turkish public relations academics and professionals. The collected data were analyzed under the guidance of Wengers’ communities of practice framework, and suggestions for forming communities of practice were proposed by taking the dimensions of events, leadership, connectivity, membership, learning projects, and artifacts into account. By providing data from Turkey, the findings of this work can help us improve industry–academia ties and subsequently contribute to the professionalization of public relations.
Degradasi Moral Siswa-Siswi Dalam Penerapan Nilai Pancasila Ditinjau Dari Pendidikan Kewarganegaraan Sebagai Pendidikan Karakter
Authors: Revalina Atiqah , Moeis Isnarmi , Indrawadi Junaidi
Published: July 2023

Penelitian ini bertujuan untuk mendeskripsikan bentuk-bentuk degradasi moral siswa-siswi dalam penerapan nilai pancasila, factor penyebab degradasi moral, implikasi degradasi moral. Subjek penelitian adalah siswa-siswi Sekolah Menengah Pertama Negeri 30 Muaro Jambi. Aspek yang diamati yaitu sikap siswa-siswi terkait dengan penerapan nilai pancasila. Metodologi yang digunakan yaitu pendekatan kualitatif deskriptif. Hasil penelitian yang didapat yaitu bentuk degradasi moral siswa-siswi dalam penerapan nilai pancasila yang paling signifikan adalah, penurunan nilai agama, penurunan nilai kemanusiaan, serta penurunan nilai persatuan. Hasil penelitian juga menunjukkan beberapa faktor penyebab degradasi moral siswa-siswi yakni lemahnya pengetahuan dan paham nilai-nilai Pancasila oleh siswa-siswi, kelalaian orangtua dalam mendidik anak, dan pengaruh gadjet atau media social. Implikasi dari degradasi moral siswa-siswi dalam penerapan nilai pancasila yakni tidak mengindikasikan hubungan manusia dengan tuhan, tidak mengindikasikan karakter peduli social terhadap hubungan hidup sesama manusia, tidak mengindikasikam karakter patriotisme dan kebersamaan, tidak mengindikasikan karakter demokratis dan tidak mengindikasikan nilai keadilan bagi semua pihak tanpa pandang bulu. Maka kesimpulan yang didapatkan yaitu adanya degradasi moral siswa-siswi dalam penerapan nilai pancasila ditinjau dari makna dan hakikat pendidikan kewarganegaraan sebagai pendidikan karakter.
Perlindungan Hukum Pengguna Layanan Urunan Dana Melalui Penawaran Saham Berbasis Teknologi Informasi
Authors: Mamma Suriyadi
Published: July 2023

Abstrak

 

Layanan urun dana melalui penawaran saham berbasis teknologi informasi (equity crowdfunding) merupakan salah satu instrumen investasi bagi masyarakat di era revolusi industri 4.0 dimana pihak perusahaan yang membutuhkan modal dapat mendapatkan dana disamping itu masyarakat yang mempunyai kelebihan dana dapat memanfaatkannya dengan menempatkan dana tersebut di sektor yang produktif dengan menggunakan perantara yang dinamakan penyelenggara layanan urun dana. Permasalahan mengenai perlindungan dana pemodal sering menjadi faktor penting yang menunjang keberlangsungan suatu bisnis karena faktor kepercayaan sehingga OJK mengatur di dalam suatu peraturan mengenai perlindungan terhadap konsumen sektor jasa keuangan. Untuk menjaga kepercayaan masyarakat diaturlah mengenai perlindungan terhadap dana pemodal terhadap tindakan pelaku usaha. Penyelenggara yang menjadi pengelola dana pemodal dan menyalurkan kepada penerbit mempunyai peran penting dalam equity crowdfunding sehingga tanggung jawab yang ada padanya juga berat, hal ini diatur dalam peraturan OJK. Metode penelitian yang digunakan adalah normatif dengan pendekatan perundang-undangan (statute approach) dengan mengkaji asas-asas dalam hukum investasi dengan peraturan perundang-undangan yang berlaku. Mengenai perlindungan terhadap dana pemodal pada dasarnya hal ini diatur dalam Peraturan OJK Nomor 1/POJK.07/2013 yang mengatur perlindungan konsumen sektor jasa keuangan terhadap perilaku pelaku usaha dan hal ini dikuatkan dengan Pasal 60 POJK Nomor 37 tahun 2018 yang membebankan tanggung jawab kerugian kepada penyelenggara atas kesalahan atau kelalaian direksi, pegawai atau pihak yang bekerja dengan penyelenggara.

Kata Kunci         : Equity crowdfunding, Investasi, Perlindungan Hukum
Prevalencia de anemia en la población mexicana: análisis de la Ensanut Continua 2022
Authors: Mejía-Rodríguez Fabiola , Mundo-Rosas Verónica , García-Guerra Armando , Mauricio-López Eric Rolando , Shamah-Levy Teresa , Villalpando Salvador , De la Cruz-Góngora Vanessa
Published: July 2023

Objetivo. Describir la magnitud de la prevalencia de anemia en la población mexicana participante en la Encuesta Nacional de Salud y Nutrición Continua 2022 (Ensanut Continua 2022). Material y métodos. La Ensanut 2022 es probabilística. Mediante sangre venosa y Hemocué (201+) se midió hemoglobina (Hb) y se ajustó por altitud. Se definió anemia según criterios de la Organización Mundial de la Salud (OMS). Considerando el diseño muestral de la encuesta, se obtuvieron prevalencias e IC95%. Resultados. Las prevalencias de anemia fueron 6.8% en niños de 1-4 años, 3.8% en niños de 5-11 años, 10.1% en adolescentes (12-19 años), 15.8% en mujeres (20-49 años) y 10.3% en adultos mayores (≥60 años). Conclusiones. La anemia afectó principalmente a las mujeres adultas. Resulta necesario identificar sus causas para focalizar acciones y evitar el ciclo intergeneracional del riesgo de anemia.
Prevalencia, tratamiento y control de la hipertensión arterial en adultos mexicanos: resultados de la Ensanut 2022
Authors: Campos-Nonato Ismael , Oviedo-Solís Cecilia , Vargas-Meza Jorge , Ramírez-Villalobos Dolores , Medina-García Catalina , Gómez-Álvarez Enrique , Hernández-Barrera Lucía , Barquera Simón
Published: July 2023

Objetivo. Describir la prevalencia de hipertensión arterial (HTA), las características del tratamiento y la proporción de adultos mexicanos que tiene tensión arterial (TA) controlada. Material y métodos. Se midió la TA a 8 647 adultos en la Encuesta Nacional de Salud y Nutrición 2022 (Ensanut 2022). Se consideró que un participante tenía HTA o TA controlada cuando cumplía los criterios de la American College of Cardiology y la American Heart Association (ACC/AHA) o la Eighth Joint National Committee (JNC-8). Resultados. La prevalencia de HTA en adultos fue 47.8% (según criterio del ACC/AHA). De éstos, 65.5% desconocía su diagnóstico. En adultos con diagnóstico previo de HTA, 33.7% tuvo TA controlada. Según la clasificación JNC-8, 29.4% de los adultos tenía HTA y 43.9% ignoraba su diagnóstico. Conclusión. En la Ensanut 2022 la mitad de los adultos tenía HTA y de ellos, tres de cada cinco no habían sido diagnosticados. El sistema de salud debe mejorar sus mecanismos de detección de HTA porque el subdiagnóstico y el mal control de la TA ocasiona discapacidad, mala calidad de vida y mortalidad prematura.
Porcentaje de enfermedad diarreica aguda en menores de cinco años en México. Ensanut Continua 2022
Authors: Delgado-Sánchez Guadalupe , Ferreira-Guerrero Elizabeth , Ferreyra-Reyes Leticia , Mongua-Rodríguez Norma , Martínez-Hernández Maribel , Canizales-Quintero Sergio , Téllez-Vázquez Norma , Cruz-Salgado Arturo , García-García Lourdes
Published: July 2023

Objetivo. Estimar el porcentaje de enfermedad diarreica aguda (EDA) en menores de cinco años en las últimas dos semanas, de acuerdo con los datos de la Encuesta Nacional de Salud y Nutrición Continua 2022. Material y métodos. Se analizaron los datos de menores de cinco años incluidos en la Encuesta Nacional de Salud y Nutrición Continua 2022 respecto a la EDA en las últimas dos semanas. Se compararon los datos con los de ediciones previas de la encuesta. Resultados. El porcentaje de EDA en México fue de 9.4% (IC95%: 7.9,11.2), similar al de 2000, con diferencias por grupo etario. Durante el episodio de EDA, 38.7% (IC95%: 27.7,51.0) de las personas cuidadoras ofrecen menor cantidad de alimentos a la habitual. Conclusiones. El elevado porcentaje de EDA en menores de cinco años en México en el 2022 evidencia la necesidad de fortalecer estrategias de prevención y promoción de la salud.