bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of the infectious factor in the genesis of perinatal losses in pregnant women who have birth in maternity hospitals in St. Petersburg and Leningrad Region in 2009–2018
Authors: Bezhenar Vitaly F. , Ivanova Lidiia A. , Ivanov Dmitry O.
Published: September 2023

BACKGROUND: One of the tasks of modern medicine is to reduce the level of perinatal losses, for which it is necessary to know their main causes.

AIM: To determine the course of an infectious disease in the genesis of perinatal losses.

MATERIALS AND METHODS: In order to determine the role of infection in the genesis of perinatal losses, a retrospective study was conducted with two groups: the main group 307 women with perinatal fetal death, the control group 357 women without perinatal losses. An analysis was also made of the data of the statistical form No. 32 (annual) Information on medical care for pregnant women, women in childbirth and puerperas, presented by the Medical Information and Analytical Centers of St. Petersburg and the Leningrad Region for 20062018 and annual reports of the Leningrad Regional Pathological Anatomical Bureau for 20062016.

RESULTS: In 20062018, the leading causes of perinatal death were intrauterine hypoxia and asphyxia during childbirth (ICD 10: P20, P21), that is, not diseases, but symptomatic conditions. Such features of reporting documentation complicate the analysis of the causes of perinatal losses and the implementation of a set of preventive measures, including at the state level. Also, according to the official report, it is impossible to assess the contribution of a specific virus and a specific localization of the lesion to the genesis of perinatal losses. In the main group, hematogenous viral and ascending bacterial infection of the placenta was detected 4 times more often. With a combination of bacterial and viral infection of the placenta, the risk of a fatal outcome increases. Infectious pathogens most frequently encountered in perinatal losses have been established.

CONCLUSIONS: The cause of more than half of the cases of perinatal losses in women who gave birth in maternity hospitals in St. Petersburg and Leningrad Region in 20092018 is an infectious pathology: viral, bacterial and viral-bacterial, and not intrauterine hypoxia/asphyxia during childbirth, as stated by the official statistics. In this regard, the main direction in the prevention of perinatal losses is the timely detection and treatment of infectious pathology.
Newborn asphyxia: features of the course of pregnancy and delivery and the structure of the placenta
Authors: Ivanova Lidiia A. , Ivanov Dmitry O. , Bezhenar Vitaly F. , Krasnogorskaya Olga L.
Published: September 2023

BACKGROUND: The main cause of early neonatal death is neonatal asphyxia. Asphyxia transferred during childbirth can lead to damage of the brain, respiratory disorders, hemodynamic disorders, and impaired renal function.

AIM: The aim of the study is to determine the factors predisposing to the birth of a child in a state of asphyxia.

MATERIALS AND METHODS: A retrospective study was conducted, which included the analysis of medical records of 11,662 women who gave birth at the Perinatal Center of the Saint Petersburg State Pediatric Medical University (level IIIB obstetric institution), whose pregnancy ended in urgent delivery. The main group included patients who gave birth to full-term babies in a state of moderate and severe asphyxia (n = 70), the control group included patients who gave birth to children without asphyxia (n = 11,592).

RESULTS: Factors predisposing to the birth of a full-term baby in a state of moderate and severe asphyxia were identified, which can be used to develop a system for predicting the birth of a child in a state of asphyxia and a set of preventive measures.

CONCLUSIONS: More frequent ascending infection of stage II and III makes it necessary to timely identify and treat a bacterial infection in all full-term pregnant women. A prognostic model for the birth of a full-term baby in a state of asphyxia has been constructed. Women at risk should undergo an additional examination at 37 weeks of pregnancy: sowing from the cervical canal for flora and sensitivity to antibacterial drugs to identify pathogenic and opportunistic microflora, childbirth should be carried out under mandatory constant monitoring control.
Molecular genetic traits and risk factors for neuroblastoma
Authors: Klimenko Lada O. , Melnikov Maksim E. , Kulyova Svetlana A. , Kondratiev Gleb V.
Published: September 2023

Neuroblastoma is the most common extracranial solid tumor in childhood, accounting for 815% of all malignant neoplasms in children. The uniqueness of the neuroblastoma etiology and pathogenesis creates significant difficulties for doctors due to the unpredictability of the course of the disease: the tumor can regress and lead to death in a short time, showing significant immunity to ongoing therapy. Early diagnosis of a tumor is necessary to understand the risk factors, the etiology, the mechanisms of neuroblastoma occurrence and further development. To date, a number of different risk factors have been identified, related both to genetic aspects and to aspects related to the course of pregnancy, birth and lifestyle of the childs parents. The list of these risk factors is still incomplete and research to identify new factors continues to this day. Morphological and molecular genetic diagnostics play an important role in this. Undifferentiated and low-differentiated variants of neuroblastoma are often associated with MYCN amplification and other chromosomal aberrations determined by molecular genetic research. Chromosomal instability plays an important role in the process of early tumor development, which probably causes the possibility of acquiring certain genetic changes, which also determines the prognosis and further therapeutic options. In this article, we have identified the most significant risk factors by comparing the results of various studies.
Diagnosis of hepatocellular carcinoma using Sonazoid: a comprehensive review
Authors: Jeong Woo Kyoung
Published: September 2023

Sonazoid contrast-enhanced ultrasonography (CEUS) is a promising technique for the detection and diagnosis of focal liver lesions, particularly hepatocellular carcinoma (HCC). Recently, a collaborative effort between the Korean Society of Radiology and Korean Society of Abdominal Radiology resulted in the publication of guidelines for diagnosing HCC using Sonazoid CEUS. These guidelines propose specific criteria for identifying HCC based on the imaging characteristics observed during Sonazoid CEUS. The suggested diagnostic criteria include nonrim arterial phase hyperenhancement, and the presence of late and mild washout, or Kupffer phase washout under the premise that the early or marked washout should not occur during the portal venous phase. These criteria aim to improve the accuracy of HCC diagnosis using Sonazoid CEUS. This review offers a comprehensive overview of Sonazoid CEUS in the context of HCC diagnosis. It covers the fundamental principles of Sonazoid CEUS and its clinical applications, and introduces the recently published guidelines. By providing a summary of this emerging technique, this review contributes to a better understanding of the potential role of Sonazoid CEUS for diagnosing HCC.
Cirugía de exéresis sobre la región externa de la pierna - reparos anatómicos
Authors: Ojeda-Fiore Hugo Antero , Alvarenga-López Carlos Tadeo , González -Cárdenas Mauricio Rafael , Ojeda-Cueto Miranda Marie , Orrego-Bobadilla Gabriela Elizabeth
Published: September 2023

El caso presentado corresponde a una paciente con un tumor de partes blandas del tercio superior de la pierna derecha, cara externa; de bajo grado de 5 cm. cuya cirugía tuvo un enfoque de resección amplia adecuada. En relación con el objetivo del trabajo de relacionar el abordaje quirúrgico de la resección de un tumor de partes blandas ubicado en la cara externa del tercio superior de la pierna con los elementos anatómicos compartimentales y extra compartimentales de la pierna, fue realizada una disección anatómica en la Cátedra de Anatomía descriptiva haciendo énfasis en los elementos del compartimiento lateral de la pierna, en donde fueron identificados: los músculos peroneos, la rama externa del nervio ciático externo o peroneo común, sus relaciones con la cabeza del peroné lado derecho y sus ramas: nervios peroneo superficial y profundo.
Carcinoma de paratiroides sincrónico bilateral: a propósito de un caso
Authors: Abed Mosciaro Ricardo Elias , Arnal Bandres Marina , Bogado Yinde Luis Alberto , Cubilla Ramos Antonio Leopoldo
Published: September 2023

El carcinoma de paratiroides (CP) es una neoplasia endocrina poco frecuente, ocurre con mayor frecuencia en pacientes con hiperparatiroidismo primario, con una incidencia del 0,5-4% de los pacientes tratados quirúrgicamente por hiperparatiroidismo primario. El diagnóstico de CP es difícil porque se superpone clínica, radiológica e histológicamente con adenoma/hiperplasia de paratiroides, se basa en la evidencia de invasión tisular local inequívoca y/o metástasis. El CP bilateral es anecdótico y el principal tratamiento es la resección quirúrgica.
Institutionalizing Community-Based Research
Authors: Abell Leslie , Downey Dennis , Pacheco Pilar
Published: September 2023

Community-Based Research (CBR) presents a wide range of benefits in higher education to students, community partners, and universities. Yet on our campus (and many others), CBR remains less common than other high-impact practices (HIPs) such as service learning and undergraduate research due to lack of effective institutionalization. Moreover, when CBR projects are undertaken, they result in a level of engagement with CBR that produces fewer of the expected benefits than is ideal. Here we detail our efforts to institutionalize CBR on our campus to appropriately expand the practice and its resulting benefits. These efforts focus on three initiatives: raising the visibility of CBR, diffusing expertise to implement CBR, and providing critical support for designing and implementing CBR. We also include our assessment plan which had to be postponed due to the COVID-19 pandemic. This plan utilizes a mixed-methods approach and will explore how our initiatives have made an impact on faculty and community partners involved with CBR, as well as assess interest and knowledge about CBR among faculty and community partners who are currently involved in service learning but not yet involved in CBR. We present our efforts as a model for other universities seeking to increase implementation of CBR.
Completing the Circle
Authors: Viehweg Stephan A , Odell Jere , Polley Ted , McLucas Nouri
Published: September 2023

IUPUI’s Center for Translating Research Into Practice (TRIP) and IUPUI University Library (Library) developed a partnership to enhance community access to faculty scholarship resulting from community-engaged and translational research. Library staff archive the scholarship of faculty affiliated with TRIP in IUPUI ScholarWorks, the campus’s open access institutional repository. The TRIP Scholarly Works Program was launched in 2013 and outcomes include benefits for faculty authors (increased readership) and for a world of readers (free access). After almost 10 years in existence, Library and TRIP staff sought to evaluate the success of this program. A survey was distributed to TRIP affiliated faculty to assess the impact of open access to their scholarship on their work as community-engaged and translational scholars. Faculty participants report a variety of benefits and yet, also indicate a need for increased program communication and fewer barriers to participation.
Interação solo estrutura: Edifício industrial em estrutura metálica com fundações superficiais assente em solo arenoso
Authors: De Jesus Bruno Vieira , Ignácio Fernanda Valinho , De Albuquerque Simone Nascimento
Published: September 2023

Este trabalho contempla a análise da interação solo estrutura de um edifício industrial em estrutura de aço com fundações superficiais em concreto armado em diferentes profundidades de solo arenoso. A estrutura foi analisada através de um modelo numérico tridimensional elástico linear em elementos finitos utilizando o software SAP2000® versão 14. São apresentadas a previsão de recalques com e sem a interação solo estrutura com a variação da profundidade das fundações, a uniformização dos recalques e a redistribuição dos esforços nos pilares. Bem como as curvas de isorecalques e recalques distorcionais para todas as profundidades das fundações, comparando os resultados com e sem a interação solo estrutura. A conclusão do estudo mostra que após a realização da interação solo estrutura os recalques distorcionais diminuíram com o aumento da profundidade das fundações, contribuindo para um melhor comportamento da estrutura, indicando a importância de uma concepção de projeto contemplando a interação solo estrutura.
Examples of the Border Guard’s involvement in EU peace missions
Authors: Konieczny Marcin
Published: September 2023

W artykule przedstawiono przykłady udziału i zaangażowania Straży Granicznej w misjach pokojowych prowadzonych przez Unię Europejską. W niniejszym opracowaniu dowiedziono, że Straż Graniczna, działając we współpracy z takimi formacjami, jak Policja, Wojsko, Służba Celna, skutecznie wspiera państwa, które znalazły się w konflikcie militarnym bądź kryzysie politycznym, gospodarczym czy narodowym. Zaangażowanie Straży Granicznej i jej współpraca z funkcjonariuszami z innych krajów polega m.in. na wymianie sprzętu technicznego najnowszej generacji, udzielaniu pomocy w procesie kontroli granic i obszarów przygranicznych oraz poszerzaniu kompetencji językowych. Artykuł udowadnia, że polscy funkcjonariusze Straży Granicznej wielokrotnie mieli okazję wykazać się doświadczeniem i umiejętnościami w procesie udzielania pomocy krajom, które znalazły się w kryzysie. Były to w szczególności Kosowo, Gruzja, Ukraina, Mołdawia, Macedonia, Grecja, Bułgaria, Rumunia i Hiszpania. Wprawdzie Unia Europejska dysponuje potężną armią, której wykorzystanie pomaga ograniczyć zagrożenia, jednak działalność Straży Granicznej zasługuje na uznanie, gdyż bez jej pomocy nie byłoby możliwe tak szybkie reagowanie na zagrożenia, które de facto dotyczą wszystkich krajów znajdujących się w pobliżu konfliktu. W opracowaniu podkreślono, że Organizacja Narodów Zjednoczonych nigdy nie angażowała Straży Granicznej w swoje działania i dotychczas koncentrowała się wyłącznie na użyciu sił zbrojnych. Niniejsza praca składa się ze wstępu, dwóch rozdziałów, streszczenia, podsumowania i bibliografii. Ze względu na specyfikę przedmiotu badań w opracowaniu zastosowano metodę badania dostępnych dokumentów oraz metodę analizy literatury przedmiotu.
Performance of an obligation towards the court pursuant to Article 1391 of the Code of Civil Procedure
Authors: Lipińska Joanna
Published: September 2023

Niniejsze opracowanie poświęcono szczegółowym zagadnieniom w przedmiocie przebiegu doręczenia pozwu lub innego pisma procesowego przez komornika na podstawie art. 1391 k.p.c. Omówiono, w jaki sposób powód może wykonać zobowiązanie, jeśli sąd wdroży procedurę określoną w art. 1391 k.p.c. W pierwszej części artykułu omówiono problem przedstawienia przez powoda dowodów przebywania pozwanego pod adresem wskazanym w pozwie. Wskazano, jakimi środkami dowodowymi powód ma możliwość udowodnienia, że pozwany przebywa pod adresem wskazanym w pozwie. Wyjaśniono również, jakie dalsze czynności podejmie sąd, jeśli wyda postanowienie o stwierdzeniu braku podstaw do uznania doręczenia za skuteczne z uwagi na nieudowodnienie przez powoda okoliczności przebywania pozwanego pod adresem wskazanym w pozwie. W dalszej części opracowania wyjaśniono drugie z możliwych zachowań powoda, umożliwiających wykonanie zobowiązania sądu poprzez wskazanie innego adresu przebywania pozwanego. Trzecią część artykułu poświęcono doręczeniu pozwu lub innego pisma procesowego wywołującego potrzebę obrony praw pozwanego za pośrednictwem komornika sądowego. Omówiono, jakie wymagania musi spełniać wniosek złożony do komornika sądowego, by nie został przez niego zwrócony. Na zakończenie wyjaśniono wszystkie możliwe warianty przebiegu czynności doręczenia pozwu za pośrednictwem komornika sądowego i omówiono konsekwencje każdego z wariantów. Wskazano również na możliwość zlecenia komornikowi sądowemu poszukiwania aktualnego adresu zamieszkania pozwanego. Niniejszy artykuł stanowi analizę obowiązujących regulacji prawnych zawartych w ustawie Kodeks postępowania cywilnego, a także dorobku literatury, w szczególności aktualnych opracowań komentarzowych.
The Profile Ecoliteracy of Students at Adiwiyata School
Authors: Salimi Moh , Susiani Tri Saptuti , Hidayah Ratna , Karsono Karsono , Fauziah Muna
Published: September 2023

Ecoliteracy and Adiwiyata School are pillars that support Education for Sustainability Development (ESD). However, most Adiwiyata schools only focus on process management, not yet on student outcomes. The purpose of this research is to describe the ecoliteracy profile at the Adiwiyata School. This study uses a case study research method with principals, teachers, parents, and students as participants. The research was conducted at the Adiwiyata School in Kebumen Regency. Data collection techniques comprise questionnaires, observation, interviews, and document studies. The data analysis technique uses interactive qualitative data analysis techniques. The results of the study show that ecoliteracy abilities include: (1) cognitive aspects showing the ability to think systematically in solving natural and social environmental problems; (2) the affective aspect shows a sense of acceptance, care, and empathy for the natural and social environment; (3) the activity aspect shows the ability to care for the surrounding environment and save energy; and (4) the spirit aspect shows admiration for the natural environment. This profile should be the focus of the development of Adiwiyata schools. The findings of this study can be a reference for implementing adiwiyata-based education by paying attention to students' ecoliteracy.
The Technology Acceptance of Intelligent Silaturrahmi-based Collaboration Gamification Mechanic (ISb-GM) in Small Medium Enterprise
Authors: Marisa Fitri , Wardhani Arie Restu , Purnomowati Wiwin , Andarwati Mardiana , Suksmawati Affi Nizar
Published: September 2023

This study evaluated the technology acceptance level of the proposed collaboration gamification framework based on the cultural principle "Silaturrahmi" and intelligent system (ISb-GM). This study uses the TAM (Technology Acceptance Model) to evaluate user acceptance of the ISb-GM framework by adding four attributes from the collaboration's parameter. 36 hypotheses are formulated with a sample of 293 respondents. Proving the hypothesis resulted in 29 hypotheses being accepted, while seven were rejected. These results suggest that the proposed framework is generally accepted. In comparison, the rejected hypothesis informs that technology needs to be applied more extended and continuously so that users can learn more about it and feel the benefits. This research has two implications. Firstly, SME developers can consider and implement this proposed framework in their communities to improve collaboration performance. Second, gamification technology developers can consider and improvise proposed gamification mechanics to develop collaboration mechanics for various fields.
Modeling of the Cooling of the Batteries of Electric Vehicles Using the Cabin Air Conditioning System
Authors: GÜNEŞ Haluk
Published: September 2023

In this study, a simulation on management of battery temperature, which is a significant problem for electric vehicles, has been made. Battery temperatures can reach up to 50 oC if not checked during quick charging and discharging processes. Such situation shortens the lifetime of battery and also increases the temperature inside the cabin. More importantly, they can be dangerous. LMS Amesim software and WLTC driving cycle have been used for the simulation. Three battery packages have been used in simulations. Temperature of the battery have been checked at three different ambient temperatures (25 oC, 30 oC, 35 oC). During the test, it has been enhanced to keep the battery temperature below 35 oC under all conditions. Air-conditioner of the vehicle has been used to cool the batteries. When the temperature increased, the air-conditioner automatically checked the operating cycle of the compressor and cooled the batteries by means of constant air flow. In conclusion, the simulation has kept the battery temperature at desired level at ambient temperatures of 25 oC and 30 oC. At ambient temperature of 35oC, battery temperature increased up to 35.2oC.
Impact of inflation severity on retirement savings: A simulation analysis of projected accumulation and de-accumulation
Authors: Foziah Hazimi , Afthanorhan Asyraf , Ghazali Puspa Liza , Tajuddin Sheikh Ahmad  Faiz Sheikh
Published: September 2023

Statistics have shown that by the age of 60, Malaysian life expectancy for males and females is expected to be 17.5 and 20.1 years, respectively. Thus, if not properly addressed by the authorities, the ageing population would contribute to a serious problem for the public by having an inadequacy of retirement wealth to sustain their lives. Considering all of these issues, the present study seeks to comprehensively examine the extent to which inflation adversely affects retirement savings. This investigation holds the potential to yield valuable insights into the accumulation of retirement wealth, thereby addressing the issue of insufficient retirement income, particularly among members of the Employees Provident Fund. Using a mathematical iteration formulation approach, the accumulation and de-accumulation of retirement wealth subject to inflation are formulated to examine the severe impact of this economic factor. Ironically, the disruptive effect of inflation on retirement savings is not severe. It is the power of compounding returns generated by dividend profits that absorbs the real impact. Despite the fact that this is a useful insight, people must plan well for their retirement savings to avoid having them eaten up by inflation. The results showed that inflation disruptions of varying degrees can negatively impact retirement funds. In order to effectively mitigate the potentially detrimental impact of inflation on retirement savings, it becomes imperative to adopt a strategic approach that encompasses various measures, like the exploration of investment opportunities that possess the potential to generate returns surpassing the prevailing inflation rate.
Perception and behavior of high school students towards developing problem solving and creativity skills to solve physics assignments
Authors: Hai Nam Nguyen , Le Huy Thanh , Thanh Hai Nguyen , Le Van Giao
Published: September 2023

This study aimed to explore the learning approaches and preferences of high school students in Vietnam when studying physics. A survey was completed by 2,040 students from ten different schools on improving problem-solving and creativity skills to solve physics assignments. The survey included eight topics related to homework, exchange, problem-solving tactics, and an emphasis on real-life applications of physics concepts. The results showed that the majority of students preferred essay-style calculus homework and sometimes exchanged and discussed ideas with their peers. In addition, most students focused on only some of the steps involved in solving physics problems, self-analyzed and expanded their solutions, and related the exercise content to real-life situations. The study also found that students preferred physics exercises with clear facts and suggestive questions, while a quarter of students preferred exercises with specific facts and clear questions. Furthermore, only a small percentage of students had a deep understanding of the ten core competencies outlined in the General Education Program of 2018. These findings have important implications for physics teachers in Vietnam, indicating the need for more opportunities for discussion and encouraging a comprehensive problem-solving approach. The study suggests incorporating more real-life applications of physics concepts into teaching to help students see the relevance of what they are learning.
Variational model with image denoising fitting term for boundary extraction of breast ultrasound images
Authors: Badrulhisam Nurdina , Ismail Nurhuda , Jumaat Abdul Kadir , Maasar Mohd Azdi , Laham Mohamed Faris
Published: September 2023

A variational model was used to extract or segment the breast ultrasound (BUS) image boundary in order to find a closed curve line of the abnormality region for further diagnosis. A recent selective variational model, termed the Convex Distance Selective Segmentation (CDSS) model, is effective at segmenting a specific image object. However, the CDSS model has difficulty segmenting noisy images. Unavoidable noise in BUS pictures leads to poor segmentation, as is widely recognized. The objective of this work is to propose a reformulation of the Convex Distance Selective Segmentation (CDSS) model for the purpose of segmenting BUS pictures. Consideration of four distinct image Denoising algorithms—Gaussian filter, Median filter, Wiener filter, and Rudin-Osher-Fatemi (ROF) algorithm—as the new fitting terms in the CDSS model leads to four variants of modified CDSS models called Modified CDSS based on Gaussian filter (MCDSSG), Modified CDSS based on Median filter (MCDSSM), Modified CDSS based on Wiener filter (MCDSSW) and Modified CDSS based on ROF (MCDSSROF). To solve the modified models, we first derived the associate Euler-Lagrange equation and solved it in Matrix Laboratory (MATLAB) software. Experiments demonstrated that the proposed MCDSSROF model based on the ROF denoising algorithm provided the highest average of Peak-Signal-To-Noise-Ratio (PSNR), Dice, and Jaccard Similarity Coefficients, indicating the highest denoising quality and segmentation accuracy in comparison to other models.
Xeno-free generation of new Yazd human embryonic stem cell lines (Yazd4-7) as a prior stage toward good manufacturing practice of clinical-grade raw materials from discarded embryos: A lab resources report
Authors: Hajizadeh-Tafti Fatemeh , Golzadeh Jalal , Akyash Fatemeh , Tahajjodi Somayyeh-Sadat , Farashahi-Yazd Ehsan , Heidarian-Meimandi Hassan , Aflatoonian Behrouz
Published: September 2023

Background: Xeno-free generation of human embryonic stem cells (hESCs) is important to prevent potential animal contaminations in culture for advanced cellbased therapeutic applications. Xeno-free production of hESCs is the first step for manufacturing clinical-grade hESC lines.
Objective: To produce new hESC lines in xeno-free condition.
Materials and Methods: This lab resources report was conducted at Stem Cell Biology Research Center, Yazd, Iran from 2019-2022. 4 new hESC lines from 11 (10 fresh and 1 frozen) donated surplus discarded human embryos were established. In this study, we report the xeno-free derivation of new Yazd hESC lines (Yazd4-7), without using immunosurgery, by culturing intact zona-free blastocysts obtained from discarded embryos onto the YhFF#8 cells as a feeder layer in a microdrop culture system. The pluripotency gene expression profile of the cell lines was assessed by reverse transcription polymerase chain reaction and the expression of specific surface markers was detected using immunofluorescent staining. In vitro differentiation was induced using embryoid body formation and gene expression profile of 3 germ layers and germ cells. Reverse transcriptase polymerase chain reaction was investigated to prove their pluripotent capacity.
Results: In sum, we have been able to generate 4 new hESC lines (Yazd4-7) from 11 discarded embryos in xeno-free culture conditions using a micro drop culture system and YhFF#8 as a human source feeder layer.
Conclusion: The outcome of this work can be the foundation for the future allogeneic cell-based therapeutic application using clinical grade good manufacturing practicederived hESC derivatives.
Key words: Derivation, Human embryonic stem cells, Human foreskin fibroblasts, Xeno-free, Good manufacturing practice, Mouse embryonic fibroblasts.
Assessing the physical vulnerability of the coastal area of Nigeria to climate change
Authors: Adeyefa Adewale Oluwagbenga , Odekunle Theophilus Odeyemi , Adesina Francis Adeyinka
Published: September 2023

This study assessed the physical vulnerability of the coastal area of Nigeria to climate change effects using indices generated from a group of factors including relief, rock types, landforms, and erosion/deposition rates. Results show the very-high vulnerability class covering the largest proportion, about 53% of the area, amounting to about 23,850 km2, largely found in the Niger Delta region. The next, high-vulnerability class covers 17%, about 7650 km2, found mostly in Lagos State and the northern fringes of the Niger Delta region. The other classes i.e., moderate, low, and very-low vulnerability extend over 10% (4500 km2), 13%, (5850 km2) and 7% (3150 km2) of the coastal area, respectively. While the moderate-vulnerability class is found only in the western part of the coastal area, the low and very-low vulnerability classes dominate the extreme eastern flank and some northern edges of the western part. The low-vulnerability class is found mainly in Ondo, Ogun, Akwa Ibom and the Cross River States. The very-low vulnerability class is found covering the Ewen community of Cross River State only. Given that 70% of Nigeria’s coastal environment falls within very-high and high vulnerability classes, the region is evidently very vulnerable to the impacts of climate change.
Bir üniversite hastanesi sağlık kurulu polikliniğine dil ve konuşma sorunları ile gelen olguların sosyodemografik-klinik özellikleri ve rapor düzeylerinin incelenmesi
Authors: KARDAŞ Burcu , KARDAŞ Ömer , UÇAR Zeynep , KAPUCU Tuğçe
Published: September 2023

Amaç: Dil ve konuşma sorunları çocuk ve ergen psikiyatri polikliniklerine en sık başvuru nedenlerinden biridir. Bizim çalışmamızın amacı çocuk ve ergen psikiyatri sağlık kurulu polikliniğine dil ve konuşma sorunları ile başvuran okul öncesi yaş grubundaki olguların sosyodemografik-klinik özelliklerini ve rapor düzeylerini incelemektir.
Gereç ve Yöntem: Sağlık Kurulu polikliniğine dil ve konuşma sorunları olup özel gereksinim raporu amacı ile Mart 2021 ve Şubat 2022 tarihleri arasında başvuran olgular taranarak 171 çocuğun verileri incelenmiştir. Dil ve konuşma sorunları; konuşmama, yaşıtlarına göre konuşma becerilerinin yetersiz olması, telaffuz-artikülasyon sorunları ve konuşmada takılma olarak kategorize edilmiştir. Bu çocukların dosya verileri (yaş, cinsiyet, özgeçmiş, soygeçmiş, gelişim testi sonuçları, tanıları, rapor düzeyleri) retrospektif olarak değerlendirilmiştir.
Bulgular: Çalışmaya alınan 171 olgunun yaş ortalaması 45,9±14,4/ay olarak saptandı. Bu olguların 115 (% 67,3) tanesi erkek cinsiyet, 56 (%32,7) tanesi kız cinsiyetti. Sağlık kurulu polikliniğine en sık başvuru nedeni en sık (%49,1) yaşıtlarına göre konuşma becerilerinde gerilik olması idi. Gelişim düzeyi için yordayıcılar önemlilik sırasına göre; okul öncesi eğitime gitme (β=370, p<0,001), hipoksi olmaması (β=237, p<0,001) ve özel eğitime gitme (β=176, p<0,001) şeklinde saptandı.
Sonuç: Otizm spektrum bozukluğu, zihinsel yetersizlik gibi birçok nörogelişimsel bozukluk dil ve konuşma sorunları ile prezente olabilir. Bu çocukların erken dönemde tespiti, tedavisi ve uygun rapor gereksinimleri büyük bir önem taşımaktadır.
Hegemonia global estadunidense e os acordos MEC/USAID (1965-1968)
Authors: Silva Darllen Almeida da , Ferreira Norma Iracema de Barros
Published: September 2023

Introdução: O presente artigo se insere no tema da História da Educação e tem como objeto de estudo o intercâmbio entre Brasil, por meio do então Ministério da Educação e Cultura (MEC), e Estados Unidos da América (EUA), representado pela United States Agency for International Development (USAID) – os famosos acordos MEC/USAID, estabelecidos no período da ditadura militar, num recorte temporal de 1965 a 1968. Nesse viés, o estudo se debruça sobre os seguintes eixos norteadores: o problema de pesquisa indaga de que forma os acordos MEC/USAID serviram para instrumentalizar a hegemonia estadunidense sobre o Brasil no campo educacional. Objetivo: O objetivo incide em compreender a constituição da hegemonia estadunidense sobre o Brasil, no contexto dos Acordos MEC/USAID (1965-1968). Metodologia: Trata-se de uma pesquisa bibliográfica, de abordagem qualitativa e que busca traçar as discussões, partindo da Análise Crítica do Discurso, na vertente de Fairclough (2001). Resultados/Conclusão: Como resultados do estudo, verificou-se que o interesse norte-americano pelos rumos da Educação Superior no Brasil no período militar, foi além do discurso de modernização, pois ao incentivar uma reorganização das universidades, impunha a partir do aparelho ideológico escolar, sua hegemonia como potência capitalista.
Desenvolvimento de um vídeo educacional como recurso de ensino em projetos de produtos para área da Saúde
Authors: Alves Júlio Cesar da Rocha , Falcão Luiz Fabio Magno , Normando Valéria Marques Ferreira
Published: September 2023

Introdução: O fortalecimento do Sistema Único de Saúde requer das instituições de ensino e pesquisa a proposição de ideias inovadoras em processos e produtos. Objetivo: O objetivo do estudo foi desenvolver e validar uma mídia audiovisual como recurso de ensino na criação de projetos tecnológicos para área da saúde. Metodologia: Trata-se de um estudo de desenvolvimento de tecnologia educacional, abrangendo etapas de estudos pré-produção, produção e validação. Ocorreu no âmbito do curso de Fisioterapia da Universidade do Estado do Pará e contou como participantes da pesquisa com estudantes do 3º e 4º ano do curso de Fisioterapia e com profissionais da área de ensino em saúde, atuando como juízes especialistas. Resultados: Como resultados do estudo de revisão foram definidos conceitos, atributos e etapas de projeto de produtos.  O estudo exploratório-descritivo demonstrou necessidade de aprimoramento nas competências relacionadas à concepção criativa de projetos e formas de representação.  Conclusão: Os resultados dos estudos iniciais embasaram a composição do roteiro e a produção do vídeo educacional. No processo de validação de conteúdo e validação semântica do vídeo educacional, obtiveram-se Índice de Validação de Conteúdo de 86% e Índice de Validação de Semântica de 97%, sendo considerado válido e adequado ao uso como recurso de ensino na criação de projetos de produtos em saúde.
N-Acetylcysteine Improves Renal Function and Reduces Tissue Malondialdehyde Levels in Glycerol-Induced Acute Kidney Injury
Authors: Hasanatuludhhiyah Nurina , Ratnani Arifian Hardi Putri , Suhartati
Published: September 2023

Introduction: The etiology of myoglobinuric acute kidney injury involves oxidative injury brought on by the Fenton reaction and myoglobin redox cycle. Renal tubules may be harmed, and lipid peroxidation compounds with vasoconstrictor characteristics may be produced. N-acetylcysteine (NAC) is an antioxidant shown to improve renal microcirculation and have protective effects in various models of renal damage. The aim of the study was to demonstrate the protective impact of NAC in glycerol-induced rats by measuring tissue malondialdehyde (MDA) level and renal function test (RFT), and to determine the correlation between the protective effect and NAC dose.Methods: This study measured tissue malondialdehyde (MDA) and renal function to examine any protective effect of NAC in a glycerol-induced rat model and to determine whether the effect was dose-related. Five groups of male Wistar rats were used: 1) saline control group, (2) glycerol (50%, 8mL/kg, i.m) plus saline i.v group, 3) glycerol plus NAC (100 mg/kg)-treated group, 4) glycerol plus NAC (200 mg/kg)-treated group, 5) glycerol plus NAC (400 mg/kg)-treated group. At 24 hrs, after glycerol injection, rats were sacrificed, cardiac blood was taken for renal function measurement, and renal tissues were removed for thiobarbituric acid MDA level assessment.Results: Our study revealed that glycerol administration significantly amplified renal tissue MDA, serum creatinine, and BUN (blood urea nitrogen) levels. However, NAC administration dampened the MDA increment and renal function deterioration (p<0.05). Moreover, tissue MDA, BUN, and serum creatinine levels were significantly correlated to NAC dose (r=0.485; r=0.491; rs=0.544, respectively; all p<0.05), indicating that NAC protection declines by dose increments.Conclusion: In this glycerol-induced acute kidney injury rat model, the administration of intravenous NAC 100 mg/kg reduced lipid peroxidation and improved renal function. Nevertheless, the protective effect was diminished in higher doses.
Association between Albuminuria and Serum Phosphate Levels in Non-Dialysis Stage 3-5 Chronic Kidney Disease Patients
Authors: Harfonso Ernesto Everald Baibelino , Mardiana Nunuk , Atika
Published: September 2023

Introduction: Chronic kidney disease (CKD) remains a global burden and catastrophic disease as about 697.5 million people suffering from it in 2017. About 42% of CKD mortality in Indonesia is related to cardiovascular complications. Hyperphosphatemia, a manifestation of chronic kidney disease-mineral bone disorder, could increase the risk of cardiovascular mortality. Albuminuria has been proven to inhibit the compensatory mechanisms for hyperphosphatemia, thereby aggravating this condition. This study was conducted to analyze the association between albuminuria and serum phosphate levels among CKD patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.Methods: This cross-sectional study used medical records of 129 non-dialysis stage 3-5 CKD patients at the outpatient clinic of Dr. Soetomo General Academic Hospital from March-November 2021. Descriptive analysis was performed on albuminuria, serum phosphate, age, sex, body mass index, comorbid, blood chemistry tests, and CKD stages data. Correlational analysis was conducted using the Spearman Rank test on albuminuria and serum phosphate levels.Results: The majority of the subjects in this study were male (55.81%); mean age was 55.21±11.99 years; mean BMI was 22.39±2.27 kg/m2; hypertension was found in 65.89% of the patients; mean eGFR was 25.01±16.1 ml/min/1.73 m2 and dominated by CKD stage 3-5. The distribution of albuminuria grade was dominated by heavy albuminuria (>300 mg/g) and the mean serum phosphate level was 4.81±1.9 mg/dl. Spearman Rank analysis found a significant positive correlation with weak association strength (p<0.001; rs=0.277) between albuminuria and serum phosphate levels.Conclusion: There was a significant positive correlation with weak association strength between albuminuria and serum phosphate levels.
Fair Value Assessment for Industrial Goods Stocks in Indonesia Post-Pandemic
Authors: Rachman Arif , Salim Dwi Fitrizal
Published: September 2023

Many industrial sectors were severely affected during the pandemic, which lasted from 2020 to 2021. Such indicators can be observed in various companies implementing efficiency measures ranging from cost reduction unrelated to revenue growth to layoff policies. Despite being under pressure due to the pandemic, many industrial subsectors experienced significant growth in the second quarter of 2021, according to statistics from the Ministry of Industry. This study aims to determine the fair value of shares in Industrial Goods companies listed on the Indonesia Stock Exchange. This approach uses a discounted cash flow (DCF) methodology with free cash flow to the company and relative valuation through price-to-earnings and price-to-book ratios. From 2017 to 2021, historical financial data was utilized to forecast future income and expenditure behavior in three scenarios: optimistic, moderate, and pessimistic. The results showed that the DCF-FCFF technique underestimated IMPC, ARNA, and UNTR. MARK is overvalued in pessimistic, moderate, and optimistic scenarios, while MARK is undervalued in optimistic scenarios. HEXA is overvalued in the pessimistic scenario but undervalued in the moderate and optimistic scenario. ARNA and UNTR were overvalued in all relative assessment scenarios using the PER approach, but MARK and HEXA were undervalued. IMPC is undervalued in a gloomy scenario and overpriced in a moderate and optimistic scenario. In all cases, the PBV method overestimates IMPC, ARNA, MARK, HEXA, and UNTR. The study implies that investors should conduct thorough due diligence before making investment decisions, considering company-specific factors and broader market conditions. Companies in the Industrial Goods sector must be ready to adapt to changing market dynamics and prioritize long-term value creation to attract and maintain investor confidence.
Building a Sustainable Supply Chain Management: A Step-by-Step Approach
Authors: Hasan Ikram , Habib Md. Mamun
Published: September 2023

In today's globalized world, supply chain management (SCM) plays a pivotal role in ensuring the smooth flow of goods and services. However, with the increasing awareness of environmental and social issues, businesses are now focusing on creating a sustainable supply chain. A sustainable SCM reduces the environmental footprint and ensures ethical practices throughout the chain. This article illustrates the steps to build a sustainable supply chain management system.
Case study: Stomach ulcers in the context of tricuspid atresia—“I can barely stomach it”
Authors: Varkey Thomas C. , Lee Roeder Chloe-Marie , Daum Rachel Elizabeth , Ravi Sajana , Courtois Emily C. , Simtion Kyle , Simtion Caitlyn , Merhavy Cheney E. , Merhavy Zachary I. , Frohman Teresa C. , Frohman Elliot M. , Spann Christie
Published: September 2023

This case study focuses on the evaluation of a patient with both upper and lower gastrointestinal (GI) complaints in the outpatient setting, that is, how the evaluation skipped over several crucial diagnostic steps, and how this impacted the patient. Special care is given to the patient’s perspective, differential diagnosis, recommended laboratory testing, and their corresponding costs, taking on a patient-centered approach to the evaluation, diagnosis, and treatment of illness. In this case, sufficient medication history was not obtained, causing the patient to undergo an expensive and unnecessary procedure. Acquiring this information is the cornerstone of an effective patient-physician relationship. Based on the history, a standardized diagnostic approach can be employed, given the likelihood of certain diagnoses. Often, the workup should start with less invasive and expensive tests. However, it is important to consider each isolated case, as a more aggressive approach may be indicated in certain instances. Special attention to communication between the patient and provider is key in ensuring that the patient understands what is happening in their medical care, which improves their communication with relevant information to the care provider, and through such understanding, our patients are better able to provide informed consent.
Assessing the Wind Power Potential in Naama, Algeria to Complement Solar Energy through Integrated Modeling of the Wind Resource and Turbine Wind Performance
Authors: Mohammed Chakib Sekkal , Zakarya Ziani , Moustafa Yassine Mahdad , Mohammed Haris Baghli , Mohammed Zakaria Bessenouci
Published: September 2023

Combining wind and solar photovoltaic (PV) generation can provide complementary renewable power production, but depends on correlated resources. This study analyzed 10 years of wind data from Naama, Algeria to evaluate the potential for evening wind generation to offset the loss of solar at sunset. Average wind speeds showed a distinct increase during evening hours, coinciding with the decrease in solar irradiance. Wind turbine simulations using a 1.5 MW turbine and the wind data showed sufficient resources for profitable power production after sunset. Statistical analyses confirmed significantly higher wind speeds and simulated power output in evening vs daylight periods (p<0.05). The Pearson correlation coefficient between evening wind speeds and decreasing solar irradiance was 0.63, supporting a strong positive relationship. These findings indicate Naama has adequate wind resources to deploy economically viable wind power capacity that can complement existing solar infrastructure and provide renewable electricity after dark , .
SEP Optimization of Power System Location and Timing Module Based on MLE-KNN Synthesis Algorithm
Authors: Xu Yawei , Wang Wei , Zhou Jia , Zhu Zhihua , Yao Changzheng
Published: September 2023

To ensure the safe operation of the power system, it is necessary to monitor and manage all kinds of power facilities. Real-time power monitoring can play a role in the early warning of geographical disasters. At the transmission end, the state detection and fault location of transmission lines are related to the normal operation of the power system. The precise time synchronization of the power system can be guaranteed through the satellite positioning time service, so that the time of various power operation actions is consistent. The accuracy can reach several microseconds, which provides a basis for the analysis of power grid operation. In this paper, by installing BeiDou functional modules in power equipment and developing the BeiDou operation platform for the distribution network, the precise management of power timing and positioning is realized by docking with the geographic information systems platform of the power grid. The three-dimensional sphere error probability (SEP) algorithm is selected to evaluate the positioning error data. Based on the three traditional SEP calculation methods, the maximum likelihood estimation algorithm is optimized and improved, which can achieve nanosecond synchronization accuracy. It can also be applied to other precision of synchronization scenarios of the power system to meet the development needs of the future clock system of the power system. Through the simulation of experimental data and comparison with other algorithms, the accuracy is verified and the reliable estimation of parameters is realized. Considering the information loss caused by dimension reduction evaluation, the simulation analysis in this paper is compared with other methods, and the accuracy is significantly improved. The power system positioning and timing module developed in this paper can not only be used in the power system but also has a certain reference and application value for other devices in the same industry that need timing and positioning services.
Environmental Uncertainty and Idiosyncratic Risk: The Dual Role of Diversification Strategy
Authors: Hua Fengtao , Tang Rui , Leng Xin
Published: September 2023

In response to escalating environmental uncertainty, corporate executives typically adjust their business strategy between diversification and refocusing. This study examines the effect of environmental uncertainty on idiosyncratic risk, as well as the moderating impact of diversification on this relationship. Utilizing a sample of companies listed on the Chinese stock market from 2005 to 2019, the results suggest that a significant positive correlation exists between uncertainty and idiosyncratic risk. As environmental uncertainty escalates, corporate managers increasingly opt for diversification before eventually refocusing their business strategy. Furthermore, while moderate diversification can mitigate the impact of uncertainty on idiosyncratic risk, excessive diversification intensifies this correlation. This research holds considerable significance for understanding the influence mechanism of idiosyncratic risk and ensuring the stability of the capital market.