bluuebunny/crossref_metadata_2025 huggingface dataset:
Mononuclear cells from patients with rhupus are influenced by TNF in their production of gp130/sIL-6Rb and APRIL
Authors: Amezcua-Guerra Luis M , Sánchez-Muñoz Fausto , Guzmán-García Santiago , Márquez-Velasco Ricardo , Becerril-Villanueva Enrique , Vázquez-Panchos Yadira , Juárez-Vicuña Yaneli
Published: October 2023

Objective

Rhupus is a rare disease that shares characteristics of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). While several studies have explored the clinical and immunological profiles of patients with rhupus, the underlying cause of the disease remains unknown due to its complex pathogenesis. The objective of this study was to investigate the role of tumour necrosis factor (TNF) in the production of inflammatory molecules by peripheral blood mononuclear cells (PBMCs) from patients with rhupus.

Methods

The study involved five healthy controls, seven patients with rhupus and seven patients with SLE. PBMCs were obtained from each participant and stimulated with recombinant human TNF for 24 hours. The levels of various molecules secreted by the cells, such as cytokines and chemokines, were measured using immunobead-based assays on xMAP technology.

Results

The production levels of some molecules were higher in TNF-stimulated PBMCs from patients with rhupus and SLE than in unstimulated cells. In addition, the levels of certain molecules, including gp130/sIL-6Rb, a proliferation-inducing ligand (APRIL), interferon-β, matrix metalloproteinase-3 and interleukin (IL)-12, were higher in PBMCs from patients with rhupus even without TNF stimulation. Similarly, the levels of gp130/sIL-6Rb and APRIL were higher in TNF-stimulated PBMCs from patients with rhupus than in healthy controls. These results were further validated against patients with RA using enzyme-linked immunosorbent assay.

Conclusions

These findings suggest that the spontaneous production of molecules by cells from patients with rhupus may contribute to the development of the disease, and that TNF may play a role in this process by regulating the secretion of gp130/sIL-6Rb and APRIL.
CASE REPORT: A SUCCESSFUL TREATMENT STRATEGY FOR CYSTIC OVARIAN DISEASE IN A DAIRY COW
Authors: Liu Yu-Jhe , Huang Hao , Li Cheng-Yan , Chan Jacky Peng-Wen
Published: October 2023

A 5-year-old multiparous lactating Holstein cow was reported to have cystic ovarian disease with a history of whitish vaginal discharge on the 80th day postpartum. On the 83rd day postpartum, transrectal ultrasonography revealed a thick-walled cystic structure with visible cobwebs in the cavity, measuring 4.2[Formula: see text]cm × 3.4[Formula: see text]cm in diameter on the right ovary. The serum progesterone (P4) concentration was 6.82[Formula: see text]ng/mL, leading to a diagnosis of luteinized follicular cyst. Transvaginal aspiration of the cyst was performed to decrease the compression of ovarian stroma by the cyst, followed by intramuscular administrations of cloprostenol and buserelin. A 1.9[Formula: see text]cm diameter corpus luteum was detected on the right ovary nine days after aspiration, with a serum P4 concentration of 1.29[Formula: see text]ng/mL. Continual hormone treatment was followed, consisting of an injection of buserelin and an intravaginal progesterone-releasing device inserted for seven days. After seven days, two corpora lutea were noted on the right ovary with an average diameter of 2.8[Formula: see text]cm and 1.8[Formula: see text]cm, respectively. The device was removed and the cow showed a P4 concentration of 11.22[Formula: see text]ng/mL on that day. Estrus induction was conducted with two low doses of cloprostenol followed by an injection of gonadorelin, to induce a complete luteolysis and the following ovulation to fit a fixed-timed artificial insemination (AI). Pregnancy was confirmed 33 days after AI. Although the number of days open was 102 in this case, it took a total of 19 days from treatment to pregnancy.
Large Language Models, Computational Chemistry, and Digital Reticular Chemistry: A Perspective and Proposed Workflow
Authors: AlGhamdi Abdullah A.
Published: October 2023

In this article, I explore the synergy between Large Language Models (LLMs) and computational chemistry in the context of digital reticular chemistry and propose a workflow leveraging these technologies to advance research and discovery in the field. I argue that understanding the intricacies of new tools is imperative before integrating them into applications, and that the proposed workflow, though robust, merely offers a glimpse into the expansive potential and applications of this field.
HPS Cholesky: Hierarchical Parallelized Supernodal Cholesky with Adaptive Parameters
Authors: Lin Shengle , Yang Wangdong , Hu Yikun , Cai Qinyun , Dai Minlu , Wang Haotian , Li Kenli
Published: October 2023

Sparse supernodal Cholesky on multi-NUMAs is challenging due to the supernode relaxation and load balancing. In this work, we propose a novel approach to improve the performance of sparse Cholesky by combining deep learning with a relaxation parameter and a hierarchical parallelization strategy with NUMA affinity. Specifically, our relaxed supernodal algorithm utilizes a well-trained GCN model to adaptively adjust relaxation parameters based on the sparse matrix’s structure, achieving a proper balance between task-level parallelism and dense computational granularity. Additionally, the hierarchical parallelization maps supernodal tasks to the local NUMA parallel queue and updates contribution blocks in pipeline mode. Furthermore, the stream scheduling with NUMA affinity can further enhance the efficiency of memory access during the numerical factorization. The experimental results show that HPS Cholesky can outperform state-of-the-art libraries, such as Eigen

LL
T

, CHOLMOD, PaStiX and SuiteSparse on 79.78%, 79.60%, 82.09% and 74.47% of 1,128 datasets. It achieves an average speedup of 1.41x over the current optimal relaxation algorithm. Moreover, 70.83% of matrices have surpassed MKL sparse Cholesky on Xeon Gold 6248.
Improved Online Scheduling of Moldable Task Graphs under Common Speedup Models
Authors: Perotin Lucas , Sun Hongyang
Published: October 2023

We consider the online scheduling problem of moldable task graphs on multiprocessor systems for minimizing the overall completion time (or makespan). Moldable job scheduling has been widely studied in the literature, in particular when tasks have dependencies (i.e., task graphs) or when tasks are released on-the-fly (i.e., online). However, few studies have focused on both (i.e., online scheduling of moldable task graphs). In this article, we design a new online scheduling algorithm for this problem and derive constant competitive ratios under several common yet realistic speedup models (i.e., roofline, communication, Amdahl, and a general combination). These results improve the ones we have shown in the preliminary version of the article. We also prove, for each speedup model, a lower bound on the competitiveness of any online list scheduling algorithm that allocates processors to a task based only on the task’s parameters and not on its position in the graph. This lower bound matches exactly the competitive ratio of our algorithm for the roofline, communication, and Amdahl’s model, and is close to the ratio for the general model. Finally, we provide a lower bound on the competitive ratio of any deterministic online algorithm for the arbitrary speedup model, which is not constant but depends on the number of tasks in the longest path of the graph.
A Lightweight, Effective, and Efficient Model for Label Aggregation in Crowdsourcing
Authors: Yang Yi , Zhao Zhong-Qiu , Wu Gongqing , Zhuo Xingrui , Liu Qing , Bai Quan , Li Weihua
Published: October 2023

Due to the presence of noise in crowdsourced labels, label aggregation (LA) has become a standard procedure for post-processing these labels. LA methods estimate true labels from crowdsourced labels by modeling worker quality. However, most existing LA methods are iterative in nature. They require multiple passes through all crowdsourced labels, jointly and iteratively updating true labels and worker qualities until a termination condition is met. As a result, these methods are burdened with high space and time complexities, which restrict their applicability in scenarios where scalability and online aggregation are essential. Furthermore, defining a suitable termination condition for iterative algorithms can be challenging. In this article, we view LA as a dynamic system and represent it as a Dynamic Bayesian Network. From this dynamic model, we derive two lightweight and scalable algorithms: LAonepassand LAtwopass. These algorithms can efficiently and effectively estimate worker qualities and true labels by traversing all labels at most twice, thereby eliminating the need for explicit termination conditions and multiple traversals over the crowdsourced labels. Due to their dynamic nature, the proposed algorithms are also capable of performing label aggregation online. We provide theoretical proof of the convergence property of the proposed algorithms and bound the error of the estimated worker qualities. Furthermore, we analyze the space and time complexities of our proposed algorithms, demonstrating their equivalence to those of majority voting. Through experiments conducted on 20 real-world datasets, we demonstrate that our proposed algorithms can effectively and efficiently aggregate labels in both offline and online settings, even though they traverse all labels at most twice. The code is onhttps://github.com/yyang318/LA_onepass.
Using focused ethnography to inform biomedical research infrastructure enhancement at primarily undergraduate institutions
Authors: Abraham Traci H. , Miller Robinson Caroline , Siegel Eric R. , Cornett Lawrence E.
Published: October 2023

This article describes results from an approach to program evaluation (i.e., focused ethnography) that has not been previously used to evaluate grant mechanisms. This “experience near” approach, which involved qualitative interviews and firsthand observations, lent valuable insights into how broader and institutional contexts at two primarily undergraduate institutions hindered or facilitated use of Arkansas INBRE resources. The insights gained can be used to enhance the Arkansas INBRE, which aims to strengthen the statewide biomedical infrastructure.
Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation
Authors: Maeoka Yujiro , Nguyen Luan T. , Sharma Avika , Cornelius Ryan J. , Su Xiao-Tong , Gutierrez Marissa R. , Carbajal-Contreras Héctor , Castañeda-Bueno María , Gamba Gerardo , McCormick James A.
Published: October 2023

The renal cation cotransporters NCC and NKCC2 are activated following phosphorylation mediated by the WNK4-SPAK/OSR1 pathway. While disruption of this pathway strongly affects NCC activity, effects on NKCC2 activity are unclear since the commonly used phospho-NKCC2 antibody was recently reported to cross-react with phospho-NCC in mice on the C57BL/6 background. Using a new phospho-NKCC2 antibody specific for C57BL/6, we show that inhibition or activation of the WNK4-SPAK/OSR1 pathway in mice only mildly affects NKCC2 phosphorylation.
Altered accumulation of hepatic mitochondrial antioxidant proteins with age and environmental heat stress
Authors: Haak Jodie L. , Kregel Kevin C. , Bloomer Steven A.
Published: October 2023

Our results suggest heat stress-induced mitochondrial translocation of Sirt-3, MnSOD, and Ref-1 in young and old animals. Aged rats experienced a decline in Trx-2 after heat stress, suggesting a potential mechanism for age-related mitochondrial dysfunction.
GPS-SBAS-Based Orbit Determination for Low Earth Orbiting Satellites
Authors: Kim Mingyu , Kim Jeongrae
Published: October 2023

A space-based augmentation system (SBAS) provides real-time GNSS correction signals via geostationary satellites for near-ground GNSS users. To use the SBAS correction for low Earth orbit (LEO) satellites, the correction, especially the ionosphere correction, must be adjusted for the LEO altitude. We apply modified SBAS data to LEO satellite onboard navigator to improve the positioning accuracy of a LEO satellite for possible real-time use. The onboard navigator requires high positioning reliability, and code pseudoranges, rather than phase pseudoranges, are used for the primary measurements. The Galileo NeQuick G model is used to determine the real-time conversion factor of the SBAS ionosphere correction for a LEO satellite. The GPS L1 data from GRACE satellite are combined with the SBAS data from the ground receiver. The onboard navigator combines the precise satellite dynamic model with an extended Kalman filter to improve positioning accuracy and stability. The kinematic positioning method, which uses the weighted least square method without the dynamic model, is also performed for comparison. The SBAS correction reduces the positioning error in both the kinematic positioning and the dynamic positioning. The positioning error reduction of the GPS and WAAS case over the GPS-only case is 25.2% for the kinematic method and 30.6% for the dynamic method. In the case of the dynamic method with the SBAS corrections, the positioning error remains smaller than that of the GPS-only dynamic method even after the satellite has left the SBAS service area.
Finite-Time Distributed Cooperative Guidance Law with Impact Angle Constraint
Authors: Zhang Wenguang , Yan Jin
Published: October 2023

The problem of the distributed cooperative guidance law of multiple missiles attacking a stationary target with impact angle constraint is investigated. A distributed cooperative guidance law, which consists of a nonsingular terminal sliding mode component for ensuring finite time convergence to the desired LOS angle and a coordination component for realizing finite time consensus of time-to-go estimates, is proposed. Analysis shows that the guidance law designed in this study can ensure that missiles’ time-to-go estimates represent real times to go once all the missiles fly along the desired LOS. Therefore, simultaneous arrival can be guaranteed. Furthermore, it is modified to accommodate the communication failure cases. Compared with existing results, this guidance law owns faster convergence rate and can satisfy large impact angles. Numerical simulations are performed to demonstrate the effectiveness of the proposed guidance law.
Bioconvection Flow in the Presence of Casson Nanoparticles on a Stretching/Shrinking Vertical Sheet with Chemical Reaction
Authors: Arun B. , Deivanayaki M. , Vaithilingam Selvakumar Kuppusamy
Published: October 2023

A Casson nanoparticle is used in this study to investigate the effects of toxic reactions, temperatures, and concentrations on convective heat transfer flow across a stretching/shrinking vertical sheet. The goal is to convert the control linear partial differential equations (PDEs) into an ordinary differential equations (ODEs) set and analyses them statistically using the Bvp4c technique in MATLAB software. It is necessary to look how various variables, such as the Casson nanofluid measurement, the chemical change constants and Prandtl numbers, the concentration-thermal-buoyancy ratio, the microorganism-to-thermal-buoyancy rate of return, the Lewis number, and other bioconvection-related parameters (such as the variation in micro-organism concentration and the buoyancy parameter), affect each other. The numerical results of the velocity, temperature, concentration, and bioconvection flow profiles are displayed.
A Cross-Sectional Study on Fall Direction and Lower Limb Loading in Response to a Perturbation on Laterally Inclined Platform
Authors: Mathunny Jaison Jacob , Srinivasan Hari Krishnan , Kumar Ashok , Karthik Varshini
Published: October 2023

Perturbation-based balance training (PBT) improves reactive stepping in older adults and people with neurological disorders. Slip-induced falls are a threat to older adults, leading to hip fractures. Fall-prone individuals must be trained to regain balance during a fall in the posterolateral direction. This study aims to analyze the characteristics of the reactive step induced by a laterally inclined platform. This cross-sectional study included 46 healthy participants who performed a “lean and release” backward fall using a platform with two inclined angles on each side. Kinovea software was used to analyze the step width. Reactive steps, characterized by crossover or medial foot placement, are preventive measures against posterolateral falls. The first objective was on the narrowed step width that was subjected to analysis using analysis of variance (ANOVA) and Tukey’s post hoc assessment, indicating a tendency toward posterolateral falls. As part of our second objective, the inclined platform resulted in uneven loading between the legs, with a preference for the unloaded leg as the reactive leg (

p
<
0.001

), as determined by Fisher’s exact test and Cramer’s V. These characteristics align closely with those observed in modified constraint-induced movement therapy (mCIMT). The angled platform had a significant effect on selecting the reactive leg, particularly at higher angles (

p
<
0.001

). Thus, the study suggested that the device is capable of inducing posterolateral falls and exhibited mCIMT characteristics.
Novel Explosive and Super Fractional Nonlinear Schrödinger Structures
Authors: Abdelwahed H. G. , Alsarhan A. F. , El-Shewy E. K. , Abdelrahman Mahmoud A. E.
Published: October 2023

The fractional nonlinear Schrödinger equation solutions have been investigated via fraction space-time derivative sense. We applied the unified technique for this model to extract new structures of waves. The fractional property structures were obtained from the model in form of hyperbolic, soliton, shock, explosive, superperiodic, and trigonometric structures. It was found that increasing fractal factors produces a change in the phase and wave frequency of propagating nonlinear waves. The physical models that explain tidal energy generation are crucial to the development of contemporary green power systems. The parametric description for wave characteristics in this process is created by the solution of nonlinear equations. The obtained solutions are applicable in new communications, energy applications, fractional quantum modes, and in science and complex phenomena in astrophysics. Finally, the proposed technique can be implemented for further fractional physical models.
Phase II Clinical Trial of Pembrolizumab and Chemotherapy Reveals Distinct Transcriptomic Profiles by Radiologic Response in Metastatic Triple-Negative Breast Cancer
Authors: Wilkerson Avia D. , Parthasarathy Prerana Bangalore , Stabellini Nickolas , Mitchell Carley , Pavicic Paul G. , Fu Pingfu , Rupani Amit , Husic Hana , Rayman Patricia A. , Swaidani Shadi , Abraham Jame , Budd G. Thomas , Moore Halle , Al-Hilli Zahraa , Ko Jennifer S. , Baar Joseph , Chan Timothy A. , Alban Tyler , Diaz-Montero C. Marcela , Montero Alberto J.
Published: October 2023

Purpose:

A single arm, phase II trial of carboplatin, nab-paclitaxel, and pembrolizumab (CNP) in metastatic triple-negative breast cancer (mTNBC) was designed to evaluate overall response rate (ORR), progression-free survival (PFS), duration of response (DOR), safety/tolerability, overall survival (OS), and identify pathologic and transcriptomic correlates of response to therapy.

Patients and Methods:

Patients with ≤2 prior therapies for metastatic disease were treated with CNP regardless of tumor programmed cell death-ligand 1 status. Core tissue biopsies were obtained prior to treatment initiation. ORR was assessed using a binomial distribution. Survival was analyzed via the Kaplan–Meier method. Bulk RNA sequencing was employed for correlative studies.

Results:

Thirty patients were enrolled. The ORR was 48.0%: 2 (7%) complete responses (CR), 11 (41%) partial responses (PR), and 8 (30%) stable disease (SD). The median DOR for patients with CR or PR was 6.4 months [95% confidence interval (CI), 4–8.5 months]. For patients with CR, DOR was >24 months. Overall median PFS and OS were 5.8 (95% CI, 4.7–8.5 months) and 13.4 months (8.9–17.3 months), respectively. We identified unique transcriptomic landscapes associated with each RECIST category of radiographic treatment response. In CR and durable PR, IGHG1 expression was enriched. IGHG1high tumors were associated with improved OS (P = 0.045) and were concurrently enriched with B cells and follicular helper T cells, indicating IGHG1 as a promising marker for lymphocytic infiltration and robust response to chemo-immunotherapy.

Conclusions:

Pretreatment tissue sampling in mTNBC treated with CNP reveals transcriptomic signatures that may predict radiographic responses to chemo-immunotherapy.
Activation of KrasG12D in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Authors: Chaudhary Priyanka , Xu Xia , Wang Guangfang , Hoj Jacob P. , Rampersad Rishi R. , Asselin-Labat Marie-Liesse , Ting Stephanie , Kim William , Tamayo Pablo , Pendergast Ann Marie , Onaitis Mark W.
Published: October 2023

We have previously identified alveolar type II cell as the cell-of-origin of KrasG12D-induced lung adenocarcinoma using cell lineage–specific inducible Cre mouse models. Using gain-of-function and loss-of-function genetic models, we discovered that active Notch signaling and low Sox2 levels dictate the ability of type II cells to proliferate and progress into lung adenocarcinoma upon KrasG12D activation. Here, we examine the phenotype of type II cells after Kras activation and find evidence for proliferation of cells that coexpress type I and type II markers. Three-dimensional organoid culture and transplantation studies determine that these dual-positive cells are highly plastic and tumor initiating in vivo. RNA sequencing analysis reveals that these dual-positive cells are enriched in Ras/MAPK, EGFR, and Notch pathways. Furthermore, the proliferation of these cells requires active Notch signaling and is inhibited by genetic/chemical Sox2 upregulation. Our findings could provide new therapeutic strategies to target KRAS-activated lung adenocarcinomas.

Significance:

Identification of progenitor like tumor-initiating cells in KRAS-mutant lung adenocarcinoma may allow development of novel targeted therapeutics.
SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
Authors: Liang Beiyuan , Zhang Evan H. , Ye Zhen , Storts Hayden , Jin Wei , Zheng Xinru , Hylton Hannah , Zaleski Olivia , Xing Xuanxuan , Miles Wayne , Wang Jing J.
Published: October 2023

The cGAS/STING cytosolic DNA-sensing pathway plays a significant role in antitumor immunity. Expression of STING is tightly regulated and commonly reduced or defective in many types of cancer. We have identified SIX4 as a significant regulator of STING expression in colon cancer cells. We showed that knockout of SIX4 decreased STING expression at the mRNA and protein levels while ectopic expression of SIX4 increased STING expression. Depletion of SIX4 led to attenuated STING activation and downstream signaling. Reexpression of SIX4 or ectopic expression of STING in SIX4 knockout cells reversed the effect. Ectopic expression of SIX4 enhanced DMXAA and cGAMP-induced STING activation and downstream signaling. Importantly, decrease of SIX4 expression substantially decreased tumor infiltration of CD8+ T cells and reduced the efficacy of PD-1 antibodies to diminish tumor growth in immune competent mice in vivo. Finally, analysis of The Cancer Genome Atlas colon cancer dataset indicated that tumors with high SIX4 expression were significantly enriched in the Inflammatory Response pathway. SIX4 expression also correlated with expression of multiple IFN-stimulated genes, inflammatory cytokines, and CD8A. Taken together, our results implicate that SIX4 is a principal regulator of STING expression in colon cancer cells, providing an additional mechanism and genetic marker to predict effective immune checkpoint blockade therapy responses.

Significance:

Our studies demonstrate that SIX4 is an important regulator of STING expression, providing a genetic marker or a therapeutic target to predict or enhance immune checkpoint blockade therapy responses in colon cancer.
Relative Effects of Minoxidil 5%, Platelet-Rich Plasma, and Microneedling in Pattern Hair Loss: A Systematic Review and Network Meta-Analysis
Authors: Gupta Aditya K. , Wang Tong , Bamimore Mary A. , Polla Ravi Shruthi , Talukder Mesbah
Published: October 2023

Background: Combination treatments may improve the utility of approved agents for the treatment of pattern hair loss (PHL); however, head-to-head comparisons are lacking. Objective: The aim of the study was to compare the efficacy of 5% minoxidil, platelet-rich plasma (PRP), and microneedling across adults with PHL insofar as change in total hair density at 24 weeks. Methods: We conducted a literature search in July 2022. Through our Bayesian network meta-analysis, we estimated treatments’ surface under the cumulative ranking distribution (SUCRA) values and relative effects – in terms of mean difference (MD). Results: Data from 27 trials, totaling 1,110 patients, were extracted. Interventions were ranked based on the probability of inducing hair density improvements: 5% minoxidil plus microneedling (SUCRA = 95.8%), 5% minoxidil plus PRP (SUCRA = 64.7%), 5% minoxidil (SUCRA = 53.9%), PRP (SUCRA = 34.9%), microneedling (SUCRA = 27.8%), and PRP with microneedling (SUCRA = 22.9%). The efficacy of 5% minoxidil plus microneedling in improving total hair density was significantly greater (p < 0.05) than 5% minoxidil monotherapy (MD = 13 hairs/cm2), PRP monotherapy (MD = 16 hairs/cm2), and microneedling monotherapy (MD = 17 hairs/cm2). Conclusion: Five percent minoxidil plus microneedling is an effective treatment option for improving hair density at 6 months in adult PHL patients.
The Influence of Nursing Interventions on Patient Outcomes: A Systematic Review
Authors: Jarelnape Ahmed Abdalla , Ali Zeinab Taha , Fadlala Aida Ahmed , Sagiron Elwaleed Idris , Osman Abdalla Mohamed , Abdelazeem Eltayeb , Balola Hamza , Albagawi Bander
Published: October 2023

Introduction: Nursing interventions encompass a wide range of activities, including physical care, emotional support, patient education, medication administration, and coordination of healthcare services. They play a significant role in patient outcomes. Aims: This study aimed to identify the most effective nursing interventions for improving patient outcomes. Methods: A systematic review was conducted to examine the impact of nursing interventions on patient outcomes across various healthcare settings. Six studies were included in the review. A comprehensive search was performed using databases such as the Cochrane Library, Google Scholar, Web of Science Core Collection, PubMed, and Scopus. Only studies published in English between January 2000 and December 2022 were included. A structured process was followed, including study selection, data extraction, aggregation of findings. Results: Findings from these studies demonstrate the positive outcomes associated with specific nursing interventions in various healthcare settings. Analysis of the selected studies revealed that nursing interventions had a significant impact on improving patient outcomes. Interventions such as patient education, medication management, infection control, pain management, wound care management, and fall prevention were found to be effective across different healthcare settings. Conclusions: Overall, the findings from this review demonstrate the positive outcomes associated with specific nursing interventions in various healthcare settings. Implementing these interventions can improve patient outcomes, enhance patient safety, and contribute to better overall healthcare quality.
alegoria da paisagem cultural brasileira
Authors: Duarte Mirela Carina Rêgo , Sá Carneiro Ana Rita , Silva Milena Torres de Melo , Soeiro Ítalo César de Moura , Rossin Mariana Silva
Published: October 2023

O texto discute a proteção da paisagem cultural brasileira levando em conta a intenção de regulamentação de um instrumento de preservação patrimonial e as implicações conceituais da paisagem como patrimônio cultural. Toma-se como pontos de inflexão a suspensão do instrumento da chancela da Paisagem Cultural Brasileira em 2014, bem como o reconhecimento de quatro paisagens culturais do Brasil pela Unesco entre 2012 e 2021, quando este instrumento ainda está em discussão no âmbito do órgão nacional de preservação patrimonial. Neste sentido, o texto propõe uma reflexão crítica sobre o instrumento da paisagem cultural brasileira no campo do patrimônio cultural, ao lado das raízes que formam a cultura brasileira, questão associada ao contexto mais amplo que atravessa a formação nacional e, consequentemente, a regulamentação das políticas de preservação do patrimônio no Brasil. A crítica almeja atrelar a paisagem cultural brasileira àquela que emerge da luta e da resistência do povo brasileiro, portanto, a umapaisagem mestiça, que precisa ser assimilada numa perspectiva inclusiva de todos os sujeitos.
In sickness and in health: the intestinal microbiome of dogs
Authors: Varallo Giovanna Rossi , Bueno Gabriela Marchiori , Brandão Cinara de Cassia , Sanches Leonardo , Oliveira Isabela Belei Delmaschio de
Published: October 2023

Studies on the interactions between the intestinal microbiome and its host have strengthened in the last decade. However, publications on this topic in dogs still need to be made available, reinforcing the need for new studies and literary data for consultation. Given this, this review aims to describe the intestinal microbiome and its interactions with the canine host, which can contribute to both health and morbid conditions in these animals. The definition of microbiome encompasses the collective genome of all microorganisms that live in a defined habitat (intestine). It is known that the dog’s intestinal microbiota is varied, composed of bacteria, archaea, viruses, fungi, and protozoa. Under normal conditions, there is commensalism between some of these microorganisms and the host, which promotes critical physiological relationships and interactions that contribute to homeostasis and the consequent health of the animal. With this in mind, it is expected that the disturbances associated with the microbiome will result in imbalances in this commensal relationship and thus precipitate the development of diseases and aggravation of other diseases, thus characterizing intestinal dysbiosis.
Um café com a Medusa, Ana Martins Marques e Hélène Cixous
Authors: Gelmini Juliana dos Santos
Published: October 2023

Ana Martins Marques (Belo Horizonte, 1977) é uma das vozes protagonistas na cena da poesia brasileira contemporânea. Meu objetivo neste artigo é investigar a reescrita da figura feminina Medusa, a partir da leitura crítico-interpretativa do poema “Um café com a Medusa”, publicado no livro Risque esta palavra (2021), tomando por base a crítica feminista de Hélène Cixous, em O riso da Medusa. Neste poema, vemos o deslocamento da representação da personagem feminina da condição de objeto para sujeito do discurso, como pretendia Beauvoir, no livro considerado como fundador do feminismo O segundo sexo.  Para nós, com Ana Martins Marques e Cixous, “basta olhar a Medusa de frente para vê-la: ela não é mortal. Ela é bela, e ela ri” (CIXOUS, 2022, p. 62).
Sarlo e Barthes: um encontro em Buenos Aires
Authors: Brandini Laura Taddei
Published: October 2023

Os escritos de Roland Barthes tiveram e continuam tendo um papel fundamental no pensamento de muitos intelectuais e escritores ao redor do mundo. Na América Latina não tem sido diferente. Na Argentina, uma de suas primeiras leitoras foi a escritora e crítica Beatriz Sarlo, que desde os anos de 1960 escreve sobre Barthes e “com” Barthes, ou seja, desenvolve seu pensamento sobre a literatura e a cultura argentinas tendo o escritor como uma de suas referências. Nesse sentido, A Cidade vista. Mercadorias e cultura urbana (2009), de Sarlo, apresenta-se como uma errância da escritora por Buenos Aires onde o incidente, noção central na concepção de escritura barthesiana, impõe-se sem dizer seu nome e possibilita a co-presença de uma cidade “vista” com uma “cidade escrita”. Isso se dá, em muitos momentos, a partir da observação de elementos da vida cotidiana que são, pouco a pouco, “desnaturalizados” por Sarlo, na execução de um movimento bastante devedor das Mitologias, aliás, evocadas no livro. Sarlo e Barthes se unem no momento da escrita e promovem não apenas a circulação dos textos, mas seu entrelaçamento em uma Buenos Aires vista e escrita, situada entre a França e a América Latina.
Beariz Sarlo, professora (um comentário sobre o método)
Authors: Kremer Natan Schmitz , Fernandez Vaz Alexandre
Published: October 2023

Resenha de SARLO, Beatriz. Clases de literatura argentina: Facultad de Filosofía y Letras, UBA, 1984-1988. Editado por Sylvia Saítta. Buenos Aires: Siglo XXI, 2022
Uma leitura do amor a partir da crítica literária feminista: um exercício ético, estético e político
Authors: Santos Claudiana Gois dos
Published: October 2023

O presente artigo busca evidenciar como o amor, por ser um dos temas mais recorrentes na literatura brasileira, já foi lido de diversos modos em nossa literatura. Uma das perspectivas que causou maior teor de mudanças foi a crítica literária feminista, que desvelou situações em que o que era nomeado como amor, em determinadas narrativas, poderia ser lido como a diminuição de uma personagem em detrimento do crescimento de outra no interior daquele universo ficcional. Essa mudança de perspectiva que ocorre em relação ao amor afeta e é afetada pelos movimentos feministas de diversas vertentes, assim como o é pelas três pontas que formam o sistema literário: quem escreve, quem lê e quem elabora as análises críticas. Assim, nessa relação de retroalimentação entre escritoras, leitoras e crítica, vemos que o amor pode, inclusive, ser ressignificado em projetos literários que estejam de algum modo relacionados com a representação de uma sociedade mais diversa e plural, rompendo com ideias que restringiam a presença feminina na literatura ao sentimentalismo simplificado ou mesmo ao amor como único interesse da vida das personagens.
Ensaio entre a crítica e literatura enquanto experiência poético filosófica
Authors: Oliveira Joilson de
Published: October 2023

Esse singelo texto traz em seu intento a ousadia de ensaiar entre a crítica e a literatura enquanto experiência poética filosófica. Consiste em enfatizar a relação entre a condição da Poesia diante da Filosofia, seus potenciais intersecções, bem como salienta o lugar donde se constrói a vivência da escrita tal qual resistência inventiva, no sentido de encontrar um lampejo de criatividade .Aliás , considerar referências filosóficas na dimensão poética abre espaço para elaboração de um estilo constituído a partir das vivências de ambas leituras, tanto poética , tanto filosófica, em busca de um caminho possível de alargar a compreensão dos limites e intersecções da experiência poético filosófica.
BRASIL-MAORI: APRENDIZADOS, PROCESSOS E REPRESENTAÇÕES MULTICULTURAIS DA NOVA ZELÂNDIA
Authors: Tavares Junior Carlos A.
Published: October 2023

Este trabalho tem como objetivo mostrar a conquista de espaços na mídia, principalmente no rádio, pelo povo indígena maori na Nova Zelândia. Diante da perspectiva dos Estudos Culturais, pretende-se assinalar os principais tópicos da inserção do povo maori na mídia neozelandesa e, desta maneira, aproximar as experiências desta integração multicultural.
PAIXÃO E CLUBISMO NO RÁDIO HIPERMIDIÁTICO: UMA ANÁLISE DAS TRANSMISSÕES ESPORTIVAS DA RÁDIO CRAQUE NETO NO YOUTUBE
Authors: Azevedo Núbia , Marques José Carlos
Published: October 2023

No Brasil, rádio e futebol difundiram-se de forma paralela, culminando em uma forte associação. Além de um dos principais responsáveis pela popularização deste esporte, foi também por intermédio desse veículo que surgiram os primeiros grandes ídolos nacionais. Assim, considerando o rádio expandido e a crescente inserção de ex-jogadores na função de comentaristas, o presente artigo objetiva analisar o fanatismo e o clubismo como estratégias de entretenimento nas transmissões esportivas da Rádio Craque Neto, além de identificar ‘se’ e ‘em quais momentos’ as imagens se sobrepõem ao áudio. Metodologicamente o estudo se fundamenta na pesquisa bibliográfica e na análise de conteúdo. Pôde-se concluir que o fanatismo e o clubismo prejudicam o exercício da função de comentarista por parte de Neto, que tem no improviso e na emoção suas principais características.
PODCASTING: UM LEGADO DAS RÁDIOS LIVRES
Authors: Sousa Sandra Sueli Garcia de , Neto José Cardoso Ferrão
Published: October 2023

As rádios livres trouxeram à tona uma série de questionamentos sobre o “fazer rádio”, na década de 1970. Essas emissoras surgiram em contraponto às rádios legalizadas e lançaram um modus operandi: linguagem mais próxima ao ouvinte, inovação, seja no estilo de locução ou no uso da voz, do silêncio e da música, portanto, uma larga sensorialidade auditiva. Anos após, não é mais preciso estar com o aparelho de rádio para acompanhar os programas: surgem os podcasts. A experiência auditiva digital nos liberta e é possível ouvir um podcast a qualquer hora e lugar, desde que haja acesso à rede. As experiências com linguagem são diversas e é sobre essa ligação com as rádios livres que o artigo trata. Utilizamos McLuhan (1964), Darnton (2005), (MACHADO et alii, 1986) e Sousa (1997) para discutir o podcast enquanto legado das rádios livres.
RÁDIO MEC: 100 ANOS DE RADIODIFUSÃO PÚBLICA NO BRASIL
Authors: Nitahara Akemi
Published: October 2023

O artigo traz parte da pesquisa sobre a institucionalização da comunicação pública no Brasil, feita em mestrado na Escola de Comunicação da UFRJ, que apresentou os principais marcos legais e históricos dos veículos da Empresa Brasil de Comunicação (EBC), por meio de pesquisa bibliográfica e legislativa. Destacamos neste artigo a trajetória da Rádio MEC, fundada em 1923 como Rádio Sociedade do Rio de Janeiro. Foram utilizados os fundamentos da comunicação pública, da economia política da comunicação e da cartografia nas comunicações. Ao longo dos anos, depois de ser doada ao governo brasileiro, a emissora alavancou o setor de radiodifusão educativa no país e foi ameaçada de ser fechada nos últimos anos.
"KHABAR LAHARIYA É A NOSSA ÚNICA ESPERANÇA": O PAPEL TRANSFORMADOR DO JORNALISMO COMUNITÁRIO SOB A PERSPECTIVA DO DOCUMENTÁRIO ESCREVENDO COM FOGO
Authors: Alves Murilo Schurt , Leite Silvia Porto Meirelles
Published: October 2023

O documentário Escrevendo com Fogo acompanha o cotidiano do jornal indiano Khabar Lahariya, que produz e dissemina notícias em pequenos vilarejos onde os grandes meios de comunicação não se fazem presentes. Nesse sentido, este trabalho buscou analisar, sob a dimensão verbal, como o material audiovisual apresenta o jornalismo comunitário como agente de transformações em prol de grupos marginalizados. Foi possível perceber que o Khabar Lahariya permitiu que a população conhecesse a realidade contextual de sua comunidade e, a partir disso, pudesse refletir sobre as dinâmicas sociais vigentes. Ademais, o protagonismo do povo na produção de notícias possibilitou a repercussão da realidade em que vivem de maneira sistemática e contínua, engajando a população para que suas reivindicações fossem atendidas.
O SIGNIFICADO DO AUTOMÓVEL PARA JORNALISTAS AUTOMOTIVOS - PARTE 1 - FERNANDO CALMON
Authors: Quintanilha Sergio Robinson
Published: October 2023

Abrindo uma série de entrevistas com jornalistas especializados em automóveis, Fernando Calmon relembra a transição da televisão para o jornalismo impresso e depois para a internet. Ex-diretor da revista Autoesporte, Calmon publica a coluna semanal Alta Roda em uma rede nacional de 60 jornais, sites e revistas. Esta entrevista faz parte da tese de doutorado do autor.
Desnorteando referências: pensamentos (pós)/(des)/(de)colonial na formação do artista da cena
Authors: Lopes Mariana Conde Rhormens
Published: October 2023

Este artigo discute os conceitos colonialismo, colonialidade, pós-colonialismo, descolonialismo e decolonialismo, discorrendo sobre suas origens, histórias, correntes, principais semelhanças e diferenças. Para tal discussão traz pensamentos de Catherine Walsh, Mudimbe, Wole Soyinka, Walter Mignolo, Aníbal Quijano, Edward Saïd e Steven Feierman. Aprofundando o debate, põe em xeque questões sobre generalizações, contradições, acesso direcionado a pesquisas culturais, favoritismos e interculturalidade crítica. Reflete sobre como tais conceitos dialogam com a formação e referências especialmente nos cursos superiores de artes da cena, trazendo provocações e problemáticas ao leitor. Traz reflexões com o termo “desnortear”, propondo alterar as referências durante anos pautadas em experiências, histórias e saberes do Norte Global.
"Ao alcance do ouvido": recompondo a História Cultural do Som
Authors: Aprobato Filho Nelson
Published: October 2023

Resenha do livro 
JOHNSON, Bruce. Earshot: Perspectives on Sound. New York; London: Routledge – Taylor & Francis Group, 2023.
Qual o lugar das neurociências na educação?
Authors: Louzada Fernando , Moreno-Louzada Luca
Published: October 2023

Nas últimas décadas surgiram inúmeras iniciativas com o objetivo de estabelecer uma ponte entre neurociências e educação. Algumas destas iniciativas tentaram precipitar o surgimento de novas disciplinas, como por exemplo a neuroeducação,  criando a ideia de que neurociência poderia ser prescritiva para a educação. Neste artigo, discordamos dessa ideia e apresentamos quais as contribuições que a neurociência pode trazer para a educação diante dos desafios de se aproximar áreas de conhecimento tão distintas.
A paralisia do sono no folclore brasileiro e em outras culturas
Authors: Sá José Felipe Rodriguez de , Mota-Rolim Sérgio Arthuro
Published: October 2023

A paralisia do sono (PS) é um estado dissociativo que ocorre principalmente durante o despertar. A PS caracteriza-se por uma alteração das funções motoras, perceptivas, emocionais e cognitivas, como a incapacidade de realizar movimentos voluntários, alucinações visuais, delírios sobre uma presença assustadora, sensação de pressão no peito, falta de ar, e, em alguns casos, medo de morte iminente. A maioria das pessoas experimenta a PS raramente, e principalmente quando está dormindo em posição supina; no entanto, a PS é considerada uma doença (parasonia) quando recorrente e/ou associada à carga emocional intensa e negativa. Curiosamente, ao longo da história da civilização humana, diferentes povos interpretaram a PS sob uma visão sobrenatural ou mística. Esquimós canadenses, por exemplo, atribuem a PS a feitiços de xamãs, que impedem o movimento e provocam alucinações de uma presença maligna. Na tradição japonesa, ocorre devido a um espírito vingativo que sufoca seus inimigos ao dormir. Na cultura nigeriana, uma personagem demoníaca ataca durante o sono e provoca paralisia. Uma manifestação moderna da PS é o relato de "abduções alienígenas", experimentadas como incapacidade de se mover durante o despertar, associadas a alucinações visuais de alienígenas. Desta forma, podemos dizer que a PS é um exemplo significativo de como um fenômeno neurobiológico específico pode ser interpretado e moldado por diferentes contextos culturais. Para explorar ainda mais a etnopsicologia da PS, nesta breve revisão apresentamos a "Pisadeira", uma personagem do folclore brasileiro originada no Sudeste do país, mas também encontrada em outras regiões com nomes variados. A Pisadeira é descrita como uma mulher idosa, feia, magra e com unhas compridas, que espreita nos telhados à noite e pisa no peito dos que dormem de estômago cheio. Esta lenda é mencionada em muitos trabalhos antropológicos, no entanto, não encontramos uma referência abrangente sobre a Pisadeira sob a perspectiva da ciência do sono. Nesta breve revisão pretendemos preencher essa lacuna. Primeiro, analisamos os aspectos neuropsicológicos da PS, e depois apresentamos o relato popular da Pisadeira. Finalmente, resumimos as muitas manifestações históricas e artísticas da PS em diferentes culturas, enfatizando as semelhanças e diferenças com a Pisadeira.
Early motor development: risk factors for delay in a population study in Southern Brazil
Authors: Zago Ana Carolina , Trettim Jéssica Puchalski , Rubin Bárbara Borges , Scholl Carolina Coelho , Coelho Fernanda Teixeira , Ulguim Fernanda , Pinheiro Luísa Mendonça de Souza , Matos Mariana Bonati de , Pinheiro Ricardo Tavares , Quevedo Luciana de Avila
Published: October 2023

OBJECTIVE: To assess risk factors associated with motor development delay at three months of age. METHODS: Cross-sectional study with mothers and their three-month-old babies in Southern Brazil. The Bayley-III Scale of Infant and Toddler Development (BSID-III) and the Alberta Infant Motor Scale (AIMS) were used to assess motor development. RESULTS: We evaluated 756 mothers and their three-month-old babies. The overall mean motor development assessed by the BSID-III and the AIMS was 104.7 (SD 13.5) and 55.4 (SD 25.4), respectively. When assessed by the BSID-III, the lowest motor development scores were among babies born by cesarean delivery (p = 0.002), prematurely (p < 0.001), and with low birth weight (p < 0.001). When assessed by the AIMS, babies born prematurely (p = 0.002) and with low birth weight (p=0.004) had the lowest motor development means. After a cluster analysis, we found that babies born by cesarean delivery, with low birth weight, and prematurely had more impaired motor development compared with children born without any risk factors. CONCLUSION: Identifying risk factors allows the implementation of early interventions to prevent motor development delay and, therefore, reduce the probability of other future problems.
Imaging of Angiogenesis in White Matter Hyperintensities
Authors: Ding Lingling , Hou Bo , Zang Jie , Su Tong , Feng Feng , Zhu Zhaohui , Peng Bin
Published: October 2023

Background

White matter hyperintensities (WMHs) are areas of increased signal intensity on T2‐weighted magnetic resonance imaging (MRI). WMH penumbra may be a potential target for early intervention in WMHs. We explored the relationship between angiogenesis and WMH penumbra in patients with WMHs.

Methods and Results

Twenty‐one patients with confluent WMHs of Fazekas grade ≥2 were included. All the participants underwent
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Ga‐NOTA‐PRGD2 positron emission tomography/magnetic resonance imaging. WMH penumbra was analyzed with masks created for the WMH and 7 normal‐appearing white matter layers; each layer was dilated away from the WMH by 2 mm. Angiogenesis array and ELISA were used to detect the serum levels of angiogenic factors, inflammatory factors, HIF‐1 alpha, and S100B. Fourteen patients with increased
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Ga‐NOTA‐PRGD2 maximum standardized uptake (>0.17) were classified into group 2. Seven patients with maximum standardized uptake ≤0.17 were classified as group 1. WMH volume and serum levels of integrin αvβ3, vascular endothelial growth factor receptor 22, and interleukin‐1β tended to be higher in group 2 than in group 1. In group 2,
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Ga‐NOTA‐PRGD2 uptake was significantly increased at the border between the WMH and normal‐appearing white matter than in WMHs (
P
=0.004). The structure penumbra, defined by fractional anisotropy, was wider in group 2 (8 mm) than in group 1 (2 mm). The cerebral blood flow penumbra was 12 mm in both groups. Angiogenesis showed a correlation with reduced cerebral blood flow and microstructure integrity.

Conclusions

Our study provides evidence that angiogenesis occurs in the WMH penumbra. Further studies are warranted to verify the effect of angiogenesis on WMH growth.