bluuebunny/crossref_metadata_2025 huggingface dataset:
Spindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review
Authors: OHSHIMA YUKIKO , NISHIO JUN , NAKAYAMA SHIZUHIDE , KOGA KAORI , AOKI MIKIKO , YAMAMOTO TAKUAKI
Published: May 2023

Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. SCL and pleomorphic lipoma (PL) represent a morphological spectrum of one disease process. The lesion typically presents as a relatively small (<5 cm), mobile, slow-growing, painless mass. Magnetic resonance imaging reveals the lesion to be a well-defined subcutaneous mass with a mixture of adipose and non-adipose components. Intense enhancement of the non-adipose component is seen after contrast administration. Histologically, SCL is composed of variable distributions of mature adipocytes, bland spindle cells and ropey collagen bundles and PL also contains pleomorphic and multinucleated floret-like giant cells. By immunohistochemistry, the spindle and pleomorphic/floret-like giant cells of SCL/PL are diffusely positive for CD34 and show loss of nuclear RB transcriptional corepressor 1 (RB1) expression. Recent cytogenetic and molecular genetic studies have shown heterozygous deletions of 13q14, including the RB1 gene. SCL/PL can be successfully treated with simple excision, with a very low recurrence rate. Knowledge of these peculiar tumors is important because it can mimic a variety of benign and malignant soft-tissue tumors. This review provides an updated overview of the clinical, radiological, histopathological, cytogenetic, and molecular genetic features of SCL/PL.
Calpain-mediated Mechanoptosis in Breast Adenocarcinoma
Authors: METAXAS GEORGIOS I. , SPYROPOULOU DESPOINA , MASTRONIKOLI SOFIANIKI , TSIAMBAS EVANGELOS , FALIDAS EVANGELOS , MARINOPOULOS SPYRIDON , MANAIOS LOUKAS , DAVRIS DIMITRIOS , FOTIADES PANAGIOTIS , PESCHOS DIMITRIOS , DIMITRAKAKIS CONSTANTINE
Published: May 2023

Calpains belong to a family of important calcium-dependent cysteine proteases. They are involved in intracellular processes including cytoskeleton disorganization and substrate proteolysis. They also enhance apoptosis and cell to cell adhesion. Calpains demonstrate also a mechanosensory function in neoplastic and malignant cells due to their implication in mechanoptosis. This is a specific type of apoptotic death induced by strong external mechanical stimuli. Anti-cytoskeleton rigidity inhibition strategies based on calpain induction lead to increased apoptosis of tumor transformed cells. Elevated intracellular calcium concentration mediated by specific receptors and channels activates calpains. In the current molecular review, we explored the role of calpains in calcium-dependent signa transduction pathways in breast adenocarcinoma in conjunction with novel agents that activate their important anti-tumor functions.
Pre-treatment Emotional Distress in Patients Receiving Radiotherapy for Gynecologic Cancers
Authors: RADES DIRK , AL-SALOOL AHMED , YU NATHAN Y. , SOROR TAMER
Published: May 2023

Background/Aim: Patients with gynecologic cancers selected for external-beam radiotherapy or brachytherapy may experience emotional distress. We aimed to identify patients who may benefit from early psycho-oncological intervention. Patients and Methods: We investigated 10 potential risk factors of emotional distress in a retrospective series of 122 patients planned for radiotherapy of gynecologic cancers. Factors included COVID-19 pandemic, number of physical problems, age, performance status, tumor site/stage, surgery, chemotherapy, brachytherapy, and history of another tumor. p-Values <0.005 indicated significance, and p-values <0.06 trends. Results: Frequencies of worry, fear, sadness, depression, nervousness, and loss of interest were 41%, 57%, 39%, 16%, 38%, and 20%, respectively. Significant associations with at least one of these symptoms were found for ≥5 physical problems and no upfront surgery. Trends were observed for chemoradiotherapy, history of another tumor, worse performance status, and younger age. Conclusion: The prevalence of pre-radiotherapy emotional distress was remarkable in patients with gynecologic cancers. Patients with risk factors may benefit from immediate psycho-oncological assistance.
V5 and High Sensitivity Cardiac Troponin T for Early Detection of Cardiac Toxicity During Left Breast Cancer Irradiation
Authors: CIRNIGLIARO VERA , PIETROSANTI SILVIA , DEMOFONTI CHIARA , DE ANGELI MARTINA , GIOVENCO DOROTEA , CEDRONE LAURA , SCIOMMARI CECILIA , CAROSI ALESSANDRA , PIETRASANTA FRANCA , RAMELLA SARA , D’ANGELILLO ROLANDO MARIA
Published: May 2023

Background/Aim: The high sensitivity cardiac troponin T (Hs-cTnT) is a myocardial damage biomarker that could have a predictive value in patients who undergo radiotherapy for left sided breast cancer. The aim of this study was to evaluate the early effect of left whole breast radiotherapy (WB-RT) on serum Hs-cTnT levels and its correlation with pre-existing factors. Patients and Methods: The study was conducted from December 2017 to May 2018. Forty-five patients with early stage left-sided breast cancer who received adjuvant breast hypofractionated RT without prior chemotherapy were included. Serum levels of Hs-cTnT were obtained before, weekly during RT, and within one week after the end of treatment. Considering the physiological variations of serum levels, an increase in Hs-cTnT (∆Hs-cTnT) of more than 30% from the baseline value was chosen as a threshold. The main cardiovascular risk factors were recorded. Dose volume histograms (DVHs) were used to provide a quantitative analysis for the whole heart, left ventricle, and left anterior descending artery (LAD). Results: Twelve of 45 patients (26.6%) showed a ∆Hs-cTnT ≥30%. The maximum Hs-cTnT level was recorded in the last week of treatment. ∆Hs-cTnT was strongly associated with heart V5 (p=0.05) and hypertension (p=0.05). Multivariate analysis confirmed the importance of the heart V5 and correlated with ∆Hs-cTnT. Conclusion: The increase in Hs-cTnT serum levels during adjuvant WB-RT suggested a correlation with the cardiac radiation dose in chemotherapy-naive breast cancer patients. A longer follow-up is needed to correlate Hs-cTnT values with cardiac events.
Linkeando: boletín del extensionista agropecuario
Authors:   Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA,   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia)
Published: May 2023

Al cumplir los primeros diez años de vida, en la mente humana surge la idea de que la infancia se está esfumando y que, con el peso que tienen esos dos dígitos, cada día llegan retos más desafiantes. Pero también se va adquiriendo consciencia de que estos años —a pesar de ser pocos— dejan lecciones aprendidas de éxito y también de errores cometidos, que en últimas son las que más aportan enseñanzas para enfrentar la juventud y la vida adulta.
Consultation Rate and Mode by Deprivation in English General Practice From 2018 to 2022: Population-Based Study (Preprint)
Authors: Vestesson Emma Maria , De Corte Kaat Lieve An , Crellin Elizabeth , Ledger Jean , Bakhai Minal , Clarke Geraldine M
Published: May 2023

BACKGROUND

The COVID-19 pandemic has had a significant impact on primary care service delivery with an increased use of remote consultations. With general practice delivering record numbers of appointments and rising concerns around access, funding, and staffing in the UK National Health Service, we assessed contemporary trends in consultation rate and modes (ie, face-to-face versus remote).

OBJECTIVE

This paper describes trends in consultation rates in general practice in England for key demographics before and during the COVID-19 pandemic. We explore the use of remote and face-to-face consultations with regard to socioeconomic deprivation to understand the possible effect of changes in consultation modes on health inequalities.

METHODS

We did a retrospective analysis of 9,429,919 consultations by general practitioners, nurses, or other health care professionals between March 2018 and February 2022 for patients registered at 397 general practices in England. We used routine electronic health records from Clinical Practice Research Datalink Aurum with linkage to national data sets. Negative binomial models were used to predict consultation rates and modes (ie, remote versus face-to-face) by age, sex, and socioeconomic deprivation over time.

RESULTS

Overall consultation rates increased by 15% from 4.92 in 2018-2019 to 5.66 in 2021-2022 with some fluctuation during the start of the COVID-19 pandemic. The breakdown into face-to-face and remote consultations shows that the pandemic precipitated a rapid increase in remote consultations across all groups, but the extent varies by age. Consultation rates increased with increasing levels of deprivation. Socioeconomic differences in consultation rates, adjusted for sex and age, halved during the pandemic (from 0.36 to 0.18, indicating more consultations in the most deprived), effectively narrowing relative differences between deprivation quintiles. This trend remains when stratified by sex, but the difference across deprivation quintiles is smaller for men. The most deprived saw a relatively larger increase in remote and decrease in face-to-face consultation rates compared to the least deprived.

CONCLUSIONS

The substantial increases in consultation rates observed in this study imply an increased pressure on general practice. The narrowing of consultation rates between deprivation quintiles is cause for concern, given ample evidence that health needs are greater in more deprived areas.
Pharmacotherapies for acute mania in adults: a systematic review and network meta-analysis of randomized controlled trials (AM-SRNMA 001) (Preprint)
Authors: Huang Wenbo , Li Yaozhi , He Shuyang , Xu Jilai
Published: May 2023

BACKGROUND

Acute manía is a serious psychiatric disorder, and there is currently a lack of comparisons for drug treatment options, including monotherapies and adjuvant therapies, for adults with acute manía.

OBJECTIVE

The aim of this study was to provide evidence-based recommendations regarding the efficacy, safety, and tolerability of currently used pharmacological treatments for adults with acute bipolar mania.

METHODS

To achieve this, we conducted a systematic review and network meta-analysis (NMA) using R software and related packages. We searched primary clinical databases until February 2023 for reports of randomized controlled trials of drug treatments and adjunctive therapies for adults with acute bipolar mania, with outcomes including efficacy (mean change from baseline to endpoint in mania rating scores), safety (clinically significant adverse events from baseline to end of treatment), and tolerability (the proportion of patients who completed the whole trial to the planned endpoint).

RESULTS

A total of 113 studies were included in our analysis, in which 23,491 participants (50.38% males; mean age = 38.6 years; mean study duration = 3.39 weeks; mean manic baseline score = 29.37) were randomly allocated to one of 51 monotherapies, adjunctive treatments, or placebo. Our results showed that tamoxifen (mean difference, -22.31 [-25.97, -18.63]) and tamoxifen+ lithium or valproate (LIT/VAL) (-16.37 [-22.55, -10.25]) had the best and second-best clinical efficacy in adults with acute bipolar mania over the placebo. Furthermore, olanzapine, paliperidone, quetiapine, ziprasidone, risperidone, divalproex, and haloperidol were significantly better tolerated than placebo. Combination therapies of antipsychotics and LIT/VAL appeared to be more effective than their corresponding monotherapies. While pharmacotherapies were associated with specific common adverse events, we found no evidence of increased incidence of headache or depression events compared to the placebo.

CONCLUSIONS

Overall, our NMAs provided important insights into the effectiveness, safety, and tolerability of pharmacological treatments for acute bipolar mania and can help guide treatment decisions for clinicians.

CLINICALTRIAL

CRD42023387438
Zeolite Effect on Solid Product Characteristics in Hydrothermal Treatment of Household Waste
Authors: Maleiva Lalak Tarbiyatun Nasyin , Purnomo Chandra Wahyu , Nugraheni Putranty Widha , Kusumawardhani Eka , Putra Leonardus Sandy Ade
Published: May 2023

The number of primary energy sources in Indonesia will run out quickly. Therefore, innovation is required to provide renewable energy sources (NRE) that accommodate the increasing energy necessities. Hydrothermal is the potential degradation process of plastic waste to generate NRE. This study aims to examine the effectiveness of the hydrothermal process in breaking down bulky raw materials and the role of zeolite as a catalyst to upgrade the quality of hydrochar as a novel solid fuel by evaluating the essential parameters through proximate and ultimate analysis.  The addition of zeolite in the hydrothermal process can increase the water content, ash content, and volatile matter and slightly decrease the calorific value and fixed carbon. The condition to obtain the best characteristics was temperature of 220 oC and the addition of 20 % zeolite.
Statistical Characterization of Bubble Breakup Flow Structures in Swirl-Type Bubble Generator Systems
Authors: Mawarni Drajat Indah , Juwana Wibawa Endra , Catrawedarma IGNB , Yuana Kumara Ari , Budhijanto Wiratni , Deendarlianto Deendarlianto , Indarto Indarto
Published: May 2023

The bubble breakup pattern on a swirl-type bubble generator (MBG) with water and air fluids was experimentally studied. The bubble breakup pattern was analyzed visually and characterized using several parameters such as Pressure Drop (∆P), Kolmogorov Entropy, Standard Deviation, and DWT (Discrete Wavelet Transform), which were taken from the extraction of pressure signals at the water inlet and outlet of the bubble generator. The wavelet spectrum of the measured signal was shown to identify the overall bubble breakup pattern, and the wavelet variance vector is proposed as a character vector to identify the bubble breakup pattern. The results show that there were three types of different flow breakup patterns: (1) static breakup, (2) dynamic breakup, and (3) tensile breakup. The observed bubble breakup sub-patterns can be categorized into tensile, moderate tensile, high tensile, dynamic, low dynamic, static, and high static sub-patterns. The static clustered breakup pattern has the highest wavelet energy compared to the tensile and dynamic clustered breakup.
Susceptibility Zoning of Soil Movement in Tawangmangu District, Karanganyar Regency with Bivariate Statistic Method - Weight of Evidence
Authors: Wirawan Dwika Rizki , Setianto Agung , Handini Esti
Published: May 2023

Tawangmangu district which is located in Karanganyar Regency, Central Java is a crowded area which is susceptible to disaster. Therefore, susceptibility zoning analysis is needed to support the planning and development of the area. The method used is bivariate statistics - weight of evidence which has never been implemented in its location. There are two types of data, data of potential and soil movement case (divided into train data as 61 points and test data as 40 points); and parameter data of soil movement causes. Parameter data of soil movement is processed to be a WoE (Weight of Evidence) parameter map through the use of train data to know the weight. Later on, it will be validated based on the AUC value. If it’s > 0,60, then the process will proceed. Parameter which has AUC value > 0,60 is type of lithology, slope, hill, elevation, slope direction, distance from the fault, and index of vegetation density. All of those parameters are attached and being final validated by test data. Further, the zonation consists of four; zone of very low soil movement susceptibility, low, medium, and high. The area of the very low soil movement susceptibility zone is 19,68%. Zone of low susceptibility is mostly 24,57%. Zone of medium susceptibility is 25,88%. Meanwhile, the zone of high susceptibility is 29,86%. The result of final validation shows that AUC value from the zoning model made belongs to a good category, which is 0,757.
The Role of Mental Health Knowledge and Perceived Public Stigma in Predicting Attitudes towards Seeking Formal Psychological Help
Authors: Wodong Griselda Maria Ancela , Utami Muhana Sofiati
Published: May 2023

The low number of individuals seeking for professional help contributes to increased mental health problems. This study aims to examine attitudes toward seeking professional help regarding mental health knowledge, perceived public stigma, age, gender, and education. The participants involved were 701 people, aged between 19-49 years old. The research instruments were the ATSPPH-SF Scale, the MHLS Scale, and the PPMHS Scale. The multiple linear regression analysis results showed that mental health knowledge and perceived public stigma together played a role in the attitudes of seeking formal help (F=46,161; p0.05). The results of the independent t-test showed differences in attitudes toward seeking help based on gender and education level (p0.05). This study concluded that knowledge of mental health, gender, and education could predict the attitudes toward formal help-seeking, while perceived public stigma and age could not predict help-seeking attitudes.
Imajinasi Pluralitas
Authors: Ikhwan Hakimul
Published: May 2023

Imajinasi jauh lebih dahsyat dari ilmu pengetahuan. Jika ilmu pengetahuan memahami realitas berdasarkan kaidahkaidah tertentu, imajinasi bisa melampaui kaidah tersebut untuk merekonstruksi pengetahuan dan realitas masa depan. Sayangnya,dari 4.264 Perguruan Tinggi Negeri dan Swasta yang tercatat di Indonesia tahun 2015 (Tempo.co 2015), sebagian besar berorientasi pada penyampaian (delivery) pengetahuan dan sangat sedikit yang berorientasi untuk menumbuhkan daya ‘imajinasi’dan kreativitas.
Thinking about Belonging in Youth Studies: Sebuah Review
Authors: Putri Ayu Aishya , Putrawan David Regiasmara
Published: May 2023

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Develop Model for Detection and Localization of Brain Tumor
Authors: Satre Prof. Dinesh , Govele Sharvari , Khandagle Harsh , Hule Shantanu , Ingale Atharva
Published: May 2023

Abstract: A brain tumor is growth of damaged cells in your brain. There are many different types of brain tumors. Some brain tumors are non-cancerous (benign) and some brain tumors are cancerous (malignant). Brain tumors can start in your brain (primary brain tumors), or cancer can start in other parts of your body and spread to your brain as secondary (metastatic) brain tumors. The rate at which a brain tumor grows can vary widely. Brain tumor growth rate and location determine how your nervous system functions. One of the most important and useful tests performed on the brain is an MRI, which is magnetic resonance imaging. All images are tested and analyzed by a radiologist, due to the rapid development in neural networks and machine learning techniques of high performance systems for detecting the diseased part of a person. Machine learning and neural network models play an important role in computer vision. In this revive paper, we did an analysis on many object detection model and summarize the research done on this domain.
IOT Based Arm Robot
Authors: Sahu Rajeshwar , Jain Harsh , Birole Roshan , Jain Achala
Published: May 2023

Abstract: The proposed IoT-based Robotic Arm system consists of a robotic arm, sensors, actuators, a microcontroller, and a wireless network module. The system allows remote operation of the arm through a web-based user interface, providing increased flexibility, reduced costs, and improved efficiency for various industries. The system can automate repetitive tasks, reducing the need for human labor and improving productivity. However, further research is needed to optimize the system's performance and address the challenges of implementing IoT-based robotic systems
Lora Based Tree Poaching Detector using Arduino
Authors: H Mr. Vinay Kumar , Uma K , Kyama Pallavi S , M Vishnavi M , Bai Sangeetha
Published: May 2023

Abstract: These days there are numerous occurrences about pirating of trees like sandal, pinewood and so forth. These trees are in all respects exorbitant. They are utilized in the restorative sciences, beauty care products. To confine their sneaking and to spare timberlands around the world some preventive estimates should be conveyed. We have built up a framework which can be utilized to confine pirating. The structure framework utilizes three sensors PIR motion detector sensor, sound detection sensor, vibration sensor module. information created from these sensors is constantly checked with the guide of LCD 16*2 Alphanumeric display. Through GPS the location of the tree will be tracked easily. As for the sensors, their yield gadgets are actuated through transfer switch. For PIR sensor and sound sensor, a signal is enacted and for temperature sensor a water siphon is actuated. For PIR sensor and sound sensor, a signal is enacted and for temperaturesensor a water siphon is actuated. For further implementation we are using LoRa wan Wi-Fi module that covers around 10km to 15km for wide range of communication to receiver moduleand we can also use satellite communication (satcom) for longer range of communication. At present we are using a Wi-Fi module in our project.
Design & Analysis of G + 5 Residential Building with Comparison of Conventional Slab and Flat Slab using ETABS
Authors: Rathod Akash S. , Motghare Anooj M. , Kamble Ishita S. , Thute Dnyaneshwari S. , Bhagadkar Piyush P. , Nagose Anshul G.
Published: May 2023

Abstract: In the conventional method, a beam with a large beam depth and a small slab thickness supports the slab. The weight is transferred from beams to columns. The flat slab is method in which the slab is resting directly on columns .The flat slab allows architects to provide partition wall wherever it is needed. To supports heavy loads and thickness of slab near the support with the column is increased and these are called drops ,or columns are provided with enlarged heads are called column heads .As the beam is not there in flat slab it gives the plain ceiling consequently giving better architectural appearance. The flat slab building is used these days because these structures offers many benefits which a normal slab structure does not provide .The objectives of this project is to compare multi-storey residential building having flat slab with conventional slab . The design and analysis is done by using ETABS software. This present work provides reasonable information about the stability of flat slab.
The classification and influencing factors of latent classes of emotional core competencies of talents with creativity-convergence
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Noh Youngju , Kim Jaechul
Published: May 2023

Objectives The purpose of this study is to identify the characteristics of each latent classes and to explore the factors affecting the classification of latent classes by sub-factors such as happiness, career maturity, creative personality, and citizen participation as emotional core competencies of talents with creativity-convergence.
Methods Among the 3,000 students (cohort of 4th grade elementary school student, 1st grade in middle school, and 1st grade in high school) who were selected in the first year of the Daegu Education Longitudinal Study (2017), the subjects of this study were fourth-year students corresponding to the first year of high school in 2020. The target marking was stratified sampling method, which divided Daegu Metropolitan City into eight administrative districts, and the schools in the area were tabulated wirelessly, and the number of schools in each target layer was determined in proportion to the number of students in the target layer compared to the total number of students. High schools were determined in proportion to the number of students by dividing them into general, special-purpose, specialized, and autonomous public high schools according to their affiliation, and 979 boys (52.5%) and 897 girls (47.8%) A total of 1,876 data were used for analysis. The emotional core competency measurement tool used a total of 49 questions related to happiness, career maturity, creative personality, and civic participation used in the longitudinal study of education, and the factors influencing this were largely divided into individual (3 factors), family (5 factors), and school (5 factors) factors, and the questions were used for analysis.
Results The number of latent classes was confirmed to be most appropriate when classified into three, and the results of analyzing the factors affecting the latent classes are as follows. First, in the individual factors, self-efficacy was found to have a very important effect on emotional core competencies. Second, in the family factor, communication with parents had the greatest influence. Third, in the school factor, support from friends was found to have the greatest influence. In particular, in the individual factors, self-efficacy was found to have a superior effect on self-efficacy in the upper group compared to the overall lower group, and the support of friends and cooperative learning had a greater effect than the support of teachers.
Conclusions Schools and educational authorities recognize the importance of communication between parents and children and positive relationships between friends and teachers, and for this purpose, it is necessary to devise and apply customized programs suitable for the characteristics of the latent classes. Efforts to develop effective strategies and practice efforts to cultivate students' emotional core competencies should be continued.
The Relationship between Elementary School Teachers' Perceived Student Problem Behavior and Burnout: Moderating Effect of Teacher Mindfulness
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Han Saem
Published: May 2023

Objectives This study explored the relationship between elementary school teachers' perception of student problem behavior, teacher mindfulness, and burnout, and verified whether mindfulness had a moderating effect on the relationship between student problem behavior and burnout.
Methods To this end, a survey of elementary school teachers located in Jeju-si was conducted from October 15 to October 30, 2020, and 165 data were used for analysis. In order to confirm the mean and standard deviation of major variables, descriptive statistical analysis and correlation analysis were performed to verify the relationship between variables. Hierarchical regression analysis was conducted to verify the moderating effect of teacher mindfulness and its sub-factors, which are regulatory variables.
Results The main results of this study are as follows. There is a significant static correlation between teacher-perceived problem behavior and burnout, and the higher the teacher's perceived problem behavior, the higher the possibility of experiencing burnout. Second, it was found that mindfulness has a negative correlation with teacher burnout, so that the more mindfulness teachers practice, the lower the burnout phenomenon. Third, as a result of examining the moderating effect of teacher mindfulness in the relationship between students' perception of problem behavior and burnout, there was no moderating effect that could alleviate teacher's burnout.
Conclusions Based on the research results, suggestions to prevent burnout of elementary school teachers and follow-up studies to explore moderating variables that can alleviate burnout caused by students' problem behaviors were suggested.
Analysis of Modeling Tasks in High School  Textbooks from a Mathematical Modeling Perspective
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Oh Se Jun
Published: May 2023

Objectives The purpose of this study was to analyze high school information textbooks from the perspective of mathematical modeling, with the goal of gaining insights for designing mathematical modeling tasks using digital resources.
Methods To achieve this objective, the study selected the ‘modeling’ unit and ‘project unit’ tasks from eight high school information textbooks for analysis, and conducted a literature review. The study examined whether the modeling tasks were related to mathematics or real-life scenarios, and analyzed them through the lens of the mathematical modeling cycle and computational thinking skills, which are increasingly recognized as crucial competencies for the future workforce, including digital literacy.
Results The material in the ‘Modeling’ unit of the high school  textbook was heavily based on ‘mathematics’.  ‘Modeling’ is treated as a method of abstraction in the textbook, and when analyzed as a process of ‘mathematical modeling cycle’, it consists of constructing, simplifying, and mathematizing. The results of the analysis showed that the treatment of ‘modeling’ in the information textbooks was distinct from ‘mathematical modeling,’ as it was seen primarily as a method of abstraction. However, the project tasks in the information textbooks included most of the components of the mathematical modeling cycle and the computational thinking process, and were organized as independent units for a systematic experience of the modeling process.
Conclusions Based on these findings, the study concludes that a systematic discussion is needed to teach ‘mathematical modeling’ in connection with modeling tasks in the information textbooks in order to foster digital literacy, which is a crucial competency for future societies. Additionally, the modeling and project tasks in the information textbooks can be modified and supplemented to be incorporated into mathematics courses. Finally, the study recommends organizing project tasks related to mathematical modeling into independent units to better structure mathematics textbooks.
Dosing-time, feeding, and sex-dependent variations of everolimus pharmacokinetics in mice.
Authors: Civelek Dilek Ozturk , Seyhan Narin Ozturk , Akyel Y. Kubra , Gazioglu Isil , Kara Zeliha Pala , Orman Mehmet , Okyar Alper
Published: May 2023

Everolimus is an oral mTOR inhibitor used as an immunosuppressant and
anticancer. Its pharmacokinetics is highly variable, it has a narrow
therapeutic window, and shows chronotoxicity with best time at ZT13 and
worst time at ZT1 in preclinical setting. In the present study, we aimed
to investigate whether the pharmacokinetics of everolimus vary according
to dosing time and whether sex and feeding status interfere the
chronopharmacokinetics. A single dosage of 5 mg/kg everolimus was
administered orally to C57BL/6J male and female mice, in fed or fasted
states at ZT1-rest and ZT13-activity times and blood and tissue samples
were collected at 0.5, 1, 2, 4, 12, and 24h following drug
administration. Plasma, liver, ileum, and thymus concentrations of
everolimus were determined. Plasma C , AUC
, and AUC were greater at
ZT13 compared to ZT1 for both sexes in each feeding states, although the
difference was not statistically significant (p=0.098). Everolimus AUC
in the liver was substantially greater at ZT1 than
ZT13 in fasted state (p=0.001). Females had a greater Ileum AUC0-24h
than males when fed (p=0.043). In one of the target organs of
everolimus, the thymus, males had considerably higher amounts at ZT1
than females (p=0.029). Our findings imply that pharmacokinetics of
everolimus in mice may differ according to dosing-time, sex, and
feeding. A greater tissue distribution of everolimus at ZT1 may be
associated with the worst tolerated time of everolimus. Our research
suggests that oral chronomodulated everolimus therapy may be more
effective and safer for cancer patients.
Recent progress of fuel-driven temporary materials
Authors: Wang Guangtong , Nan Mengmeng , Guo Kangle , Pan Yaqi , Jia Tao , Liu Shaoqin
Published: May 2023

Fuel-driven dissipative self-assembly, which is a well-established
concept in recent years, refers to out-of-equilibrium molecular
self-assembly initiated and supported by the addition of active
molecules (chemical fuel). It widely exists in nature since many
tempo-rary, active micro- or nanostructures in living bodies are
generated by the dissipative self-assembly of biomolecules. Therefore,
the study on dissipative self-assembly provides a good opportunity to
have an insight into the microscopic mechanism of living organisms. In
the meantime, dissipative assembly is thought to be a potential pathway
to achieve dynamic, temporary supramolecular materials. Recently, a
number of temporary materials have been developed with the aid of
strategies for realizing dissipative self-assembly. Some of their
properties, including solubility, stiffness, turbidity, color, or
self-healing ability, change upon the addition of chemical fuel but
spontaneously restore with chemical fuel consumption. The dynamic of
these materials brings them various unprecedented functions. In this
review, the principles of fabricating a fuel-driven temporary material
are first reviewed and subsequently, recent examples of fuel-driven
temporary materials are emphatically summarized, including gels,
self-erased inks, nanoreactors, self-healing materials, and
nanochannels. Finally, the challenges of developing fuel-driven
temporary materials and some perspectives on the function and
application of such kind of materials are discussed.
Indices of The Autonomic Nervous System Predict Affect and Emotional Contagion, But Not Anxiety: A Two-Dimensional Autonomic Space Approach
Authors: Sinai Yarden Menashri , Ma Yaopeng , Daleski Michal Abba , Gannot Sharon , Bartsch Ronny , Gordon Ilanit
Published: May 2023

To date, studies focusing on the connection between psychological
functioning and autonomic nervous system (ANS) activity usually adopted
the one-dimensional model of autonomic balance, according to which
activation of one branch of the ANS is accompanied by an inhibition of
the other. However, the sympathetic and parasympathetic branches also
activate independently; thus, co-activation and co-inhibition may occur.
The autonomic balance and regulatory capacity model accounts for such a
diversity of autonomic activities. In the present study, we adopted a
refinement of this model to assess how markers of the autonomic space
relate to several critical psychological constructs: emotional contagion
(EC), general anxiety, and positive and negative affect (PA and NA). We
analyzed data from 408 healthy students, who underwent a 5-minute
baseline period as part of their participation in several experiments
and then completed self-reported questionnaires. During the baseline,
electrocardiogram (ECG), electrodermal activity (EDA), and respiratory
activity were recorded. Respiratory sinus arrhythmia (RSA), as well as
cross-system autonomic balance (CSAB) and regulation (CSAR), were
calculated. A comparison between psychological and physiological indices
revealed distinct patterns of psychological associations for each
physiological index: CSAB was positively correlated with EC and
negatively correlated with PA and NA. Negative associations were noted
between CSAR and EC. EDA was positively correlated with PA and NA and
negatively linked to EC. We thus provide support for using the
two-dimensional autonomic space framework in psychophysiological
research. The advantages of the autonomic balance and regulatory
capacity model are discussed.
Identification of sanguinarine metabolites in rats by UPLC-Q-TOF-MS/MS
Authors: liu mengting , liu zhiqin , dong zhuang , zeng jianguo , yang zihui
Published: May 2023

Rationale: Sanguinarine (SAN), as the main active component of a
traditional Chinese veterinary medicine, have been widely used in animal
husbandry and breeding industry. However, the metabolites of SA are
still uncertain. Therefore, This research aimed to investigate the
metabolites of SA based on rats in vivo. Methods: Blood, feces and urine
of rats were collected after oral administration of 40 mg/kg SAN.
Ultra-high performance liquid chromatography coupled to quadrupole
time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) was employed to
identify the metabolites of SAN. The elemental composition of
sanguinarine metabolites was inferred by analyzing their exact molecular
weight, and the metabolites’ structure were predicted based on their
fragment ions and cleavage pathways. Results: A total of 12 metabolites
were identified, including three metabolites in plasma, four in urine
and nine in feces. Accord to the possible metabolic pathways deduced in
this study, SAN was mainly metabolized by reduction, oxidation,
demethylation, hydroxylation and glucuronidation. Conclusions: The
present research have summarized the metabolism of SAN in rats, which is
helpful to further study on metabolic mechanism of SAN in vivo and in
vitro.
A tale of two catchments: Causality analysis and isotope systematics reveal mountainous watershed traits that regulate the retention and release of nitrogen
Authors: Bouskill Nick , Newcomer Michelle E. , Carroll Rosemary W.H. , Beutler Curtis A , Bill Markus , Brown Wendy S , Conrad Mark E , Dong Wenming , Falco Nicola , Maavara Taylor , Newman Alexander , Sorensen Patrick O , Tokunaga Tetsu K , Wan Jiamin , Wainwright Haruko Murakami , Zhu Qing , Brodie Eoin , Williams Kenneth Hurst
Published: May 2023

Mountainous watersheds are characterized by variability in functional
traits, including vegetation, topography, geology, and geomorphology,
which together determine nitrogen (N) retention, and release. Coal Creek
and East River are two contrasting catchments within the Upper Colorado
River Basin that differ markedly in total nitrate (NO3-) export. The
East River has a diverse vegetation cover, sinuous floodplains, and is
underlain by N-rich marine shale, resulting in a three to twelve times
greater total NO3- export relative to the conifer-dominated Coal Creek.
While this can partly be explained by the larger size of the East River,
the distinct watershed traits of these two catchments imply different
mechanisms controlling the aggregate N-export signal. A causality
analysis shows biogenic and geogenic processes were critical in
determining NO3- export from the East River catchment. Stable isotope
ratios of NO3- (δ15NNO3 and δ18ONO3) show the East River catchment is a
strong hotspot for biogeochemical processing of NO3- at the
soil-saprolite interface and within the floodplain prior to export. By
contrast, the conifer-dominated Coal Creek retained nearly all
(~97 %) atmospherically-deposited NO3-, and its export
was controlled by catchment hydrological traits (i.e., snowmelt periods
and water table depth). The conservative N-cycle within Coal Creek is
likely due to the abundance of conifer trees, and a smaller riparian
region, retaining more NO3- overall and reduced processing prior to
export. This study highlights the value of integrating isotope
systematics to link watershed functional traits to mechanisms of
watershed element retention and release.
Longitudinal dependence of ionospheric irregularities to maximum ring current and PPEF sensed by GNSS and magnetometers during the storm of 4 November 2021
Authors: Imtiaz Nadia , Feyissa Teshome Dugassa , Calabia Andres , Kashcheyev Anton
Published: May 2023

We employ multi-instrumental data to investigate the behavior of
equatorial and low latitude ionosphere during the geomagnetic storm of
November 3-6, 2021. We used TEC data obtained from GPS receiver stations
located in the equatorial and low-latitudes of the Asian, African, and
American sectors. It is found that the storm-time ionization level
varies significantly in the trough and crest of EIA region over the
three longitudes. ROTI is used to estimate the occurrence of ionospheric
plasma irregularities during the storm. Usually, the main phase of the
geomagnetic storm triggers the equatorial plasma irregularities and the
recovery phase suppresses the occurrence of them. Here, we observed
inhibition of the plasma irregularities over the three sectors during
the main phase of the storm. We suspect this may be due to the injection
of the PEFs which occur between local midnight and around noon during
the main phase. The PEFs restrict the diffusion of plasma and therefore,
suppress the occurrence of plasma irregularities during the main phase.
During the recovery phase, moderate ionospheric irregularities occurred
at local midnight in the American sector. In the African sector, the
occurrence of weak irregularities can be seen before midnight on
November 5 and 6. However, the Asian sector does not exhibit noticeable
ionospheric irregularities during the storm. We conclude that the
longitudinal variation in the development of ionospheric irregularities
can be influenced by factors such as local time occurrence of maximum
ring current, PPEF, disturbance wind dynamo electric field, and
shielding electric field.
Optimizing the Implementation Plan of Watershed Best Management Practices with Time-varying Effectiveness under Stepwise Investment
Authors: Shen Shen , Qin Cheng-Zhi , Zhu Liang-Jun , Zhu A-Xing
Published: May 2023

Optimizing the spatial configuration of diverse best management
practices (BMPs) can provide valuable decision-making support for
comprehensive watershed management. Most existing methods focus on
selecting BMP types and locations but neglect their implementation time
or order in management scenarios, which are often investment-restricted.
This study proposes a new simulation-optimization framework for
determining the implementation plan of BMPs by using the net present
value to calculate the economic costs of BMP scenarios and the
time-varying effectiveness of BMPs to evaluate the environmental
effectiveness of BMP scenarios. The proposed framework was implemented
based on a Spatially Explicit Integrated Modeling System and
demonstrated in an agricultural watershed case study. This case study
optimized the implementation time of four erosion control BMPs in a
specific spatial configuration scenario under a 5-year stepwise
investment process. The proposed method could effectively provide more
feasible BMP scenarios with a lower overall investment burden with only
a slight loss of environmental effectiveness. Time-varying BMP
effectiveness data should be gathered and incorporated into watershed
modeling and scenario optimization to better depict the environmental
improvement effects of BMPs over time. The proposed framework was
sufficiently flexible to be applied to other technical implementations
and extensible to more actual application cases with sufficient BMP
data. Overall, this study demonstrated the basic idea of extending the
spatial optimization of BMPs to a spatiotemporal level by considering
stepwise investment, emphasizing the value of integrating physical
geographic processes and anthropogenic influences.
Evaluation of leaf phenology of different vegetation types from local to hemispheric scale in CLM
Authors: Li Xiaolu , Carrillo Carlos M. , Ault Toby , Richardson Andrew , Friedl Mark A. , Frolking Steve
Published: May 2023

Accurate simulation of plant phenology is important in Earth system
models as phenology modulates land-atmosphere coupling and the carbon
cycle. Evaluations based on grid-cell average leaf area index (LAI) can
be misleading because multiple plant functional types (PFT) may be
present in one model grid cell and PFTs with different phenology schemes
have different LAI seasonal cycles. Here we examined PFT-specific LAI
amplitudes and seasonal cycles in the Community Land Model versions 5.0
and 4.5 (CLM5.0 and CLM4.5) and their relationship with the onset of
growing season triggers in the Northern Hemisphere. LAI seasonal cycle
and spring onset in CLM show the best agreement with MODIS for
temperature-dominated deciduous PFTs. Although the agreement in LAI
amplitude between CLM5.0 and MODIS is better than CLM4.5, the agreement
in seasonal cycles is worse in CLM5.0. CLM5.0 also simulates higher soil
moisture and shows lower influences of soil moisture on LAI amplitudes
and seasonal cycles. While productivity depends on the environmental
factors to which the plant is exposed during any given growing season,
differences in phenology sensitivity to its environment necessitate a
decoupling between the seasonality of LAI and GPP, which in turn could
lead to biases in the carbon cycle as well as surface energy balance and
hence land-atmosphere interactions. Because the discrepancy not only
depends on parameterizing phenology but phenology-environment
relationship, future improvements to other model components (e.g., soil
moisture) could better align the seasonal cycle of LAI and GPP.
Ovarian aspergilloma in an immunocompetent patient masquerading as ovarian neoplasm
Authors:   King George’s Medical University, Lucknow, India, Singh Gyanendra , Singh Anurag ,   King George’s Medical University, Lucknow, India, Verma Anuragani ,   King George’s Medical University, Lucknow, India
Published: May 2023

Aspergillus is a ubiquitous fungus that can cause a variety of clinical syndromes. It can lead to a spectrum of clinical presentations depending upon the severity of the disease, degree of immune compromisation, nature and intensity of inflammatory host response. Ovarian aspergilloma is extremely unusual, only a few case reports have been described in the literature. Here, we report a case of ovarian aspergilloma which was masquerading as ovarian neoplasm on clinical examination and radiology. To the best of our knowledge, this is the first case report of isolated ovarian aspergillosis in an immunocompetent patient.
Acute Aortic Syndrome in a patient with COVID-19
Authors:   Entre o Douro e Vouga Hospital Center, Santa Maria da Feira, Portugal, Cunha João Campos , Cruz António José ,   Entre o Douro e Vouga Hospital Center, Santa Maria da Feira, Portugal, Madureira Beatriz ,   Entre o Douro e Vouga Hospital Center, Santa Maria da Feira, Portugal
Published: May 2023

The global effects of the COVID-19 pandemic make it of the utmost importance to comprehend its mechanisms and define strategies for the most effective approach possible. The SARS-CoV-2 virus can be responsible for the induction of a hypercoagulable state, which can trigger vascular phenomena of venous etiology, specifically deep venous thrombosis or pulmonary embolism. Arterial thrombotic events associated with COVID-19 have also been described in the medical literature, although less frequently. In this paper the authors report the case of a 66-year-old man who was diagnosed with an Acute Aortic Syndrome, specifically an intramural thrombus on the aortic arch, while he was still infected with the virus. Anticoagulation with low weight molecular heparin was initiated and the patient was admitted at the Internal Medicine ward for a conservative therapeutic approach. The thrombus remained stable on a serial imaging evaluation; therefore, the patient was discharged with oral anticoagulation with subsequent follow-up in the outpatient clinic. This case describes a rare and potentially serious complication of COVID-19, which highlights how broad its clinical spectrum can be, affecting systems other than the pulmonary.
Non-islet cell tumor hypoglycemia associated with Gastrointestinal Stromal Tumor: Case report and review of the literature
Authors:   Department of Internal Medicine, The Brooklyn Hospital Center, New York, USA, Kumar Vikash , Gala Dhir ,   School of Medicine, American University of the Caribbean, Cupecoy, Sint Maarten, Wonders Carson ,   School of Medicine, American University of the Caribbean, Cupecoy, Sint Maarten
Published: May 2023

Non-islet cell tumor hypoglycemia is an uncommon paraneoplastic phenomenon commonly associated with tumors of mesenchymal origin like gastrointestinal stromal tumors (GIST). It causes the release of insulin-like growth factor type II. GIST are frequently asymptomatic but can present with vague symptoms such as gastrointestinal bleeding, gastric pain, anorexia, nausea, and vomiting. We present an interesting case of A 62-year-old male with GIST tumor admitted for refractory hypoglycemia found to have non-islet cell tumor hypoglycemia which is a relatively uncommon cause of hypoglycemia.