bluuebunny/crossref_metadata_2025 huggingface dataset:
A Magyar Királyi Csendőrség nyomozó munkája szervezeti keretének kiépülése
Authors: Szigetvári Oszkár
Published: December 2022

A testület eredetileg nem rendelkezett a nyomozásokra specializálódott szakszolgálati ággal. A testületen belüli specializáció részeként azonban a nyomozásra szakosodott szakmai struktúra mégis létrejött, bár sajátos formában. A csendőrségi nyomozó szervezet két lépcsőben alakult ki. Először a XX. század elején a járásőrmesterségek létrehozásával keletkeztek csendőrségi nyomozó beosztások. Ekkor azonban a nyomozó munka — mint ahogyan később sem — nem vált markánsan szét a közrendvédelmi tevékenységtől. A járásőrmesterségeket az I. világháború után megszüntették. A húszas években azonban fokozatosan új nyomozó struktúrát építettek ki. Ennek az volt a lényege, hogy a Központi Nyomozó Parancsnokság és alárendelt szerveinek nem alkotta feladatát az őrsök helyett megvalósítandó nyomozó munka, hanem az őrsökön folyó nyomozások elősegítése.
A Magyar Királyi Csendőrség ékítményei és rendfokozatai
Authors: Zeidler Sándor
Published: December 2022

A Magyar Királyi Csendőrség a magyar állam katonailag szervezett fegyveres őrtestülete volt. Ennek megfelelően ékítményeiben a magyar állam jelképei tükröződtek. A testület rangrendszere pedig a korabeli magyar haderő szárazföldi haderejének a rendfokozati rendszerével volt szinte teljesen azonos. A magyar csendőrség azonban nem használta a lángoló gránát jelképet, pedig a világon mindenütt a csendőr szervezeteknek ez a megkülönböztető motívuma más szervezetektől. Ennek az oka abban rejlik, hogy a külsőségek tekintetében is markánsan el kívánta magát határolni a testület a magyarságot felszámolni kívánó neoabszolutista hatalom állami terrorszervezetétől a császári birodalmi csendőrségtől.
Appréhender le changement des catégories pour l’étude d’une dynamique spatiale sur le temps long
Authors: Plumejeaud-Perreau Christine , Nahassia Lucie , Gravier Julie
Published: December 2022

À travers trois exemples issus d’études des dynamiques de peuplement en France sur le temps long, intra et interurbaines, cet article montre que l’introduction d’ontologies « a-historiques » a facilité la mise en place d’analyses numériques quantifiant les dynamiques spatiales. Cependant il démontre que ces ontologies ne sont pas neutres, qu’elles ne dissolvent pas la spécificité des sources mobilisées, et constituent au contraire des savoirs situés. Mais au-delà de ces critiques, les auteures tendent à argumenter que le processus de construction et de dialogue établi autour d’ontologie a-historique est très bénéfique à la recherche, qu’il est un socle pour une science interdisciplinaire, partagée et pérenne.
Cancer from Different Perspectives: Roaming in the Alleys of Developmental and Evolutionary Biology
Authors: Sarbashis Hota
Published: December 2022

Our understanding of ‘cancer’ has evolved with scientific break-throughs, which provided insight into the pathogenesis of tumour progression. Oncology, in many occasions, has emerged as a field of interdisciplinary study, as multiple areas of cross-talks exist between the streams like developmental and evolutionary biology. This fact is often overlooked among medical professionals. The article tries to focus on epistemology of cancer research, the changing philosophy in a nutshell and a brief review of two broad domains of Biological Science; regarding how they have shaped our understanding of cancer.
Entrepreneurship: Theory, Genesis, Socio-Cultural Dimensions and Strategies
Authors: Martynyshyn Yaroslav , Khlystun Olena , Antonivska Maryna , Krupa Oksana
Published: December 2022

Introduction. In terms of economic relations transformation in Ukraine, entrepreneurship, which today, to a certain extent, goes beyond the scope of usual economic functions and roles, and is a socio-cultural phenomenon with its own history and civilizational specificity, occupies a special place. Given this, it should be considered not only as an economic category but also as a system of values and a special cultural phenomenon. Purpose and methods. The purpose of the article is a theoretical analysis of entrepreneurship as a unique phenomenon, which will deepen the understanding of its essence, socio-cultural dimensions, and strategies at various stages of society's historical development. The methodological basis of the study is the dialectical principle of cognition, systemic, historical, cultural, and interdisciplinary approaches to the study of organizational phenomena in society. Results. The history of the scientific opinion formation about entrepreneurship is considered. Socio-cultural principles and strategies of entrepreneurship are revealed. The cultural and historical factors of the entrepreneur's personality formation have been identified. The entrepreneurship functions and the role of an entrepreneur in society are analyzed. Determinants of activation and prospects for entrepreneurial activity development are determined. Conclusions. The scientific novelty of the research results lies in the cultural deepening of the understanding of the entrepreneurship essence as a unique socio-cultural phenomenon at various stages of the historical development of human society. The significance of the research is manifested in the addition of science with new theoretical provisions on entrepreneurship, as well as in the possibility of using them in the process of professional training of entrepreneurs and managers.
Spatial Semiotics and Landscape Hermeneutics in the Professional Training of Managers of Socio-Cultural Activity
Authors: Boyko Olga , Zuiev Serhii , Povalii Tatiana , Otroshchenko Larysa
Published: December 2022

Introduction. Socio-cultural activity managers' training involves students’ mastering and fluent operating the concepts of “cultural landscape” and “semiosphere”, which are used to carry out hermeneutic and semiotic analyses of regional and world culture phenomena. Purpose and methods. The article aims to reveal the main provisions of spatial semiotics and landscape hermeneutics and determine their didactic potential in the context of socio-cultural activity managers' training. Research methods include analyzing cultural, art history, and philosophical literature, theoretical generalization, and synthesis. Results. When analyzing cultural space and cultural phenomena as texts, concepts and terms are used that characterize cultural space as a semiotic system: language, text, metatext, intertextuality, and communication. One of the essential shared objects of spatial semiotics and landscape hermeneutics is the city, the high degree of semioticization determined by such essential features as “doneness” and “artificiality”. Conclusions. Space and culture interact and influence each other. At the same time, spatial categories such as “center”, and “periphery” appear as universal models for describing texts and phenomena of any branch of the cultural sphere. The analysis of landscape and cultural phenomena is carried out according to the parameters of the level of semiotic saturation of the environment; the level of significance of symbolic activity; the intensity of semiotic exchange; level of self-identification.
Assessment of a Socio-Cultural Product Quality
Authors: Tymchenko Yuliia
Published: December 2022

Introduction. Every day, the vast majority of society members are active consumers of various types of socio-cultural products. This gives a significant impetus to the more progressive development of the socio-cultural sphere and the need to improve the quality of its products. The question of how exactly to measure and analyze the consumer's perception of the quality of a certain socio-cultural product is relevant. To understand how a consumer evaluates the quality of a certain socio-cultural product, first of all, it is necessary to discover how he builds his own logical judgments about this product. Purpose and methods. The purpose of the article is to study the characteristics that determine consumers' conclusions about the quality of a socio-cultural product, regardless of whether they do it directly or indirectly. The research methodology consists of the application of system-functional and system-structural analysis as the theoretical basis of this study, which precisely allows the revealing of the relationship between these characteristics. Results. Determining the causal structure of the conceptual representation of a socio-cultural product – a park of culture and recreation, making it possible to reveal a clear relationship between the nature of the property, its causal status, accessibility for understanding, and its significance. The nature of the property determines its place in the system of relationships. Structural properties have the obvious status of a cause, procedural properties determine the obvious status of an effect, and an impression is an impression and a point of convergence of several relationships. Conclusions. The presented research results convincingly prove the applicability of theoretically grounded casual models of socio-cultural analysis both at the level of fundamental research and in applied fields.
Breeding work with lines and families of the large white breed of pig factory type «Bahachansky»
Authors: Berezovskyiy M. D. , Vashchenko P.A.
Published: December 2022

The results of the study of the genealogical structure and the current state of productivity of various structural elements of the "Bagachanskyi" factory type ten years after its approval and approval are presented. The research was conducted in the conditions of the large white breeding plant of PAF "Ukraine" of the Poltava region and in the selection laboratory of the Institute of Pig Breeding and Agro-Industrial Production. The purpose of the research was to develop a program of selection measures to increase the productivity of pigs of the factory type "Bagachanskyi" of the large white breed. It was established that compared to 2015, the share of animals imported from other farms decreased from 4.3% to zero in sow pedigrees, and from 27.5% to zero in boar pedigrees.This is due to the fact that PAF "Ukraine" acquired the status of a breeding farm, and the pig herd of this farm was involved in the creation and approval of the factory type of pigs "Bagachanskyi". Therefore, after 2010, the importation of boars from other farms took place in a limited number and exclusively for breeding purposes, and after 2014, the stud farm completely switched to self-repair not only with pigs, but also with boars. Thanks to the purposeful breeding work in the herd on development indicators and meat qualities, the consolidation of repair young animals according to these characteristics reached the maximum level (the coefficient of variation is in the range from 0.33 to 1.62%).At the same time, the absence of a significant difference between families complicates the breeding work and reduces the opportunities for intrabreedheterosis. The use of index selection, including based on linear BLUP models, contributed to the achievement of a high level of indicators of reproductive qualities (+14.8-16.0% compared to the requirements for the elite class) without deterioration of indicators based on the characteristics of bacon thickness and the age of reaching a weight of 100 kg . When evaluating the genotype by the BLUP method, it was found that the most productive offspring in terms of reproductive qualities are predicted to be obtained from sows of the Ella family. At the same time, the most significant improvement will occur at the expense of the trait of nest mass, while the sows of the Beatrice family have the highest genetic potential for multifertility. Among boars, the Slavutych line is characterized by the best BLUP breeding value index.
Age characteristics of reproducive and maternal qualities of sheep of the prekos breed
Authors: Pomitun I. A. , Kosova N. A. , Korkh I. V. , Pankiv L.P. , Bezvesilna A.V. , Boyko N. V. , Pomitun L. I. , Danilova T. N.
Published: December 2022

The studies were carried out during 2020-2021 on ewes (515 heads) of the Kharkiv intrabreed type of the Prekos breed (KhTP) and their offspring in the conditions of the breeding plant of the State Enterprise of the Experimental Farm Gontarovka of the Institute of Animal Sciencе of the National Academy of Sciences of Ukraine.

It was established that for 45 days during artificial insemination, the fertility of sheep (OP), calculated according to the results of their lambing, averaged 91.8 %. The highest rate was characterized by sheep that had the third lamb - 97.3 %. According to the results of 4-6 lambs, a relatively stable high fertility of queens was noted - 93.4-95.3 %. Significant downward deviations of this indicator were observed in ewes used for reproduction in the first and second years, and especially in animals with 7 and 8 or more lambing. Analysis of variance found that the age factor of ewes is highly likely (p<0.01) associated with their fertility, and the strength of its influence ŋх 2 is 0.491.

The factor of individual rams-producers also influences (OP) ewes. The variability due to the influence of this factor varied from 87 to 95.1 %.

Different (OP) of ewes, due to their age, had a corresponding effect on the indicators of their multiple pregnancy (P), calculated per 100 inseminated heads. This indicator in ewes for the first fifth lamb ranged from 113 to 150 lambs. At the same time, there is a clear trend of its growth due to the increase in the number of reproductive years. However, this trend is not linear and is valid for animals with 1-6 lambs. Ewes with 7 and 8 or more lambs worsen their reproductive ability rather sharply.
Digestibility of nutrients in quails at different levels of energy in feed
Authors: Otchenashko V. V.
Published: December 2022

The relevance of the study is due to the limited existing research, mainly on Japanese quails, the lack of data on the dynamics of changes in nutrient use during the productive cycle of meat quails and the impact of energy levels. The aim of the study is to study the dynamics and relationship of feed nutrient digestibility with energy levels of pharaoh laying quails. The experiment was conducted by the method of groups. According to the scheme of the experiment at the age of 45 days, 150 quails were selected, from which, according to the principle of analogous groups, 5 groups were formed – control and 4 experimental, 30 heads (25 females and 5 males) in each. The level of metabolic energy in the feed of the control group was 13.4 MJ / kg, the 2nd group – 10.7 MJ, the 3rd group – 12.1 MJ, the 4th group – 14.7 MJ, the 5th group – 16.1 MJ Quails of all groups received loose complete feed, compiled according to special recipes. During the experiment, three series of physiological experiments were conducted to study the digestibility of nutrients. For this purpose, three laying hens at 116, 200 and 284 days of age were selected from each group according to the principle of analogues. Zootechnical analysis of samples was carried out according to generally accepted methods according to the Weende analysis scheme. It is established that the use of compound feeds with different content of metabolic energy affects the digestibility of nutrients. The highest levels of nutrient utilization were observed when feeding feed with a metabolic energy content of 1.34 MJ. The nature of the changes depends largely on the age of the quails. The absence of a noticeable difference in digestibility during 2-5 months of laying for feeding feeds with an energy content of 1.09 to 1.34 MJ is a prerequisite for the development of special feeding programs aimed at minimizing costs. The presence of insignificant influence of the level of energy nutrition of quails on the digestibility of protein (rs = - 0.34, P> 0.1) was noted. The age of quails is inversely related to protein digestibility (rs = - 0.57; P <0.05).
Fisheries and fisheries development in the Pridneprovye region: problems and prospects
Authors: Novitskyi R. O. , Dvoretskyi A. I.
Published: December 2022

Based on ichthyological and fishery fees and own observations for 2015─2021 in the reservoirs of the Dnieper, the processing of official statistics obtained original data on the state of fisheries in the region. The world tendencies and tendencies of growth of consumption of fish products are analyzed. It is noted that the main trend in the development of the fishing industry is the development of aquaculture. It is proved that in recent years in the field of fisheries of the Dnieper there is a significant decline in production (2.5–4 times). Over the last 10 years, 1/3 of farms have not been able to adapt to work in the new economic conditions and have become unprofitable. In 2020, 473.149 tons of fish products were grown in Dnipropetrovsk region, which is one of the lowest figures in recent years. Not a single kilogram of fish products was obtained in pools and growing ponds.

Such facts clearly indicate the negative trends in aquaculture in the region. Growing fish is becoming a non-profit business. In the absence of any targeted state aid to fisheries, the latter will inevitably collapse. Commercial fishing (fishing) officially caught 1939.463 tons of fish and 1.131 tons of crayfish in the reservoirs of Dnipropetrovsk region. It is noted that the total value of these aquatic bioresources at the exchange price is only 10.76 million UAH. The cost of aquatic bioresources in Ukraine today is extremely low. This stimulates the development of commercial fisheries and promotes the growth of unaccounted and unaccounted for fisheries. The growing role of recreational (amateur) fishing in the use of aquatic bioresources of Ukrainian reservoirs is noted. It is proposed to introduce monthly, seasonal, annual permits for paid recreational and sport fishing: for the winter season – UAH 173; for the summer-autumn season – UAH 341.7; per year – UAH 504.9; for one month – UAH 56.1.

The cost of a permit for the summer-autumn season for a float will be UAH 235.45, for a spinner – UAH 574.26. It is noted that the estimated amount of economic contribution of amateur fishermen of the Dnieper region only for fishing permits to the budget of Ukraine can be at least 10.000.000 UAH per year. This is quite comparable to the state's profit from commercial fishing in the reservoirs of Dnipropetrovsk region. Measures to support state fisheries in the Dnieper region, improve existing approaches to fisheries and aquaculture are proposed.
Рrevention of reproductive diseases in animals with the use Nanobiomaterials
Authors: Sklyarov P. M. , Fedorenko S. Ya. , Naumenko S. V.
Published: December 2022

The aim of the work was to develop methods for the prevention of reproductive pathologies using drugs containing nanobiomaterials. This is due to the fact that the physiological functioning of the reproductive organs is rich in the state of the antioxidant defense system, the main active component of which are antioxidants that neutralize the negative effects of free radicals – specific products of cell life and their damage factors.

Work on the development and manufacture of drugs was performed on the basis of the Department of Veterinary Reproductology of the State Biotechnology University (Kharkov) and the Department of Nanocrystalline Materials of the Institute of Scintillation Materials (Kharkov), implementation – in farms of various forms of ownership.

Developed methods for the prevention of reproductive pathologies of animals (normalization of the structure and function of the fetoplacental complex of cows and sheep and increase the development potential of newborn calves and lambs, increase the reproductive capacity of bulls and boars) are based on the use of vitamin and hormonal drugs «Caplaestrol + OV», «Carafest + OV» and «Carafand + OV» containing nanobiomaterial – gadolinium orthovanadate activated by europium, the nanoparticles of which are able to penetrate cells and accumulate in nuclei.

The obtained data allow us to conclude that the use of nanobiomaterials ensures the effectiveness of programs for the prevention of reproductive pathologies of animals. In particular, the method of normalizing the structure and function of the fetoplacental complex of cows and sheep and increase the development potential of newborn calves and lambs provides an increase in placental weight by 23,4-24,3 %, newborn weight – by 18,6-29,6 %, increase in the number of cotyledons by 2,9-3,0 % and the area of the hairy part of the chorion – by 13,3-34,7 %, and the method of increasing the reproductive capacity of bulls and boars allows to increase the volume of ejaculate by 4,2-28,7 %, increase sperm motility by 16,7-28,1 %, sperm concentration – by 4,8-13,6 %, testosterone levels – by 16,8-44,2 % and reduce the number of sperm with morphological abnormalities by 1,6-2,4 %.
Microelement provision of cows of the western region of Ukraine
Authors: Vlizlo V. V. , Sedilo M. I.
Published: December 2022

The article presents the results of research on the content of trace elements: Cobalt, Zinc, Copper and Manganese in the soils, fodder and blood of cows of the black and spotted Ukrainian breed in farms from the mountain, foothill and plain zones of the Western region of Ukraine. The western biogeochemical zone of Ukraine includes Zakarpattia, Lviv, Chernivtsi, Ternopil, Volyn and Rivne regions.

It was established (mg per 1 kg of soil) that the amount of Cobalt was 0.5 mg/kg; Cuprum – 7.2; Zinc – 3.1; Manganese – 6.5; in the foothills – Cobalt – 0.6; Cuprum – 4.5; Zinc – 1.8; Manganese – 32; in the plain – Cobalt – 0.55; Cuprum – 5.0; Zinc – 1.5; Manganese – 39. During the analysis of the rations, it was established that the provision of other mineral substances did not meet the physiological needs. Thus, in the diets of cows from mountain, foothill and plain regions, an excess of Calcium, Magnesium, Potassium and Ferrum and a deficiency of Phosphorus, Sulfur, Zinc, Cobalt, Iodine and Copper were observed.

Clinical studies of cows indicate the prevalence of trace element diseases in them. Anemia of visible mucous membranes and non-pigmented areas of the skin was recorded in cows, the number of erythrocytes in animals of the mountain zone was 5.7±0.29 T/l, in the foothills – 5.8±0.29, and in the plains – 6.2±0.30 T / l. The hemoglobin content in the blood of cows in the mountain zone was at the level of 97.0±5.40 g/l, in the foothills – 94.0±5.30, and in the plain zone – 98.0±3.70 g/l. Physiological values of the number of erythrocytes in the blood of cows range from 5.0–7.5 T/l, and the hemoglobin content – 95–125 g/l.
Absorption of dry matter, crude ash, and crude fat in the gastrointestinal tract of bugai at different amounts of soluble protein in the diets
Authors: Kozyr V. S. , Petrenko V. I. , Maistrenko A. N. , Dimchya G. G.
Published: December 2022

In red steppe cattle with duodenal and ileocecal anastomoses when fed isoenergetic, isoprotein hay-concentrate rations with different levels of soluble protein (SR), the digestibility of dry matter (SR), crude ash (CW) and crude fat (CW) was studied separately in a complex stomach , small (TnK) and large (TsK) intestinal sections. Different amounts of RchSP in the rations were achieved by feeding grist from natural and roasted peas at a temperature of 105°C.

When feeding the experimental ration with a reduced level of RchSP against the background of a decrease in the apparent intensity of digestion, which was manifested in a smaller amount of duodenal and ileocecal chyme, significant changes in the digestibility of SR, SZ and SZ were observed in the postruminal sections of the gastrointestinal tract. According to the general digestibility of SR in the entire alimentary canal and prestomach, in the small and large intestines, there were different directions and degrees of changes in the experimental and control diets. The digestibility of SZ, while being the same in the entire alimentary canal, differed most significantly between rations in the complex stomach and TsK, less so in TnK. On the experimental diet, absorption of dietary fiber in the small and large intestines was 18% lower. The actual level of digestibility of dietary fiber in the animal body did not correspond to the value determined by the formula "feed minus feces" and was 2 times higher in the control diet and 1.4 times higher in the experimental diet.

The assimilation of dietary fiber in the studied rations in the alimentary canal had a multidirectional character and, in general, was lower in the experimental ration. The actual digestibility of dietary fiber, compared to the "visible" digestibility of the control diet, was 17% higher, and the experimental diet was 3% lower.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN STUNTING PADA ANAK USIA 12-59 BULAN
Authors: Sinaga Ruth Dearani , Sukamto Ika Sumiyarsi , Wiboworini Budiyanti , Wahidah Nurul Jannatul , Sari Atriany Nilam
Published: December 2022

Stunting menggambarkan status gizi kurang yang bersifat kronik pada masa pertumbuhan dan perkembangan sejak awal kehidupan. Kejadian stunting terbesar di Kota Surakarta terdapat di wilayah Puskesmas Sangkrah yaitu 17,4% dan jumlah anak dengan stunting terbanyak terdapat di Kelurahan Semanggi yaitu 39,1%. Tujuan penelitian untuk mengetahui faktor-fakor yang berhubungan dengan kejadian stunting pada anak usia 12-59 bulan di Kelurahan Semanggi Kota Surakarta. Jenis penelitian ini analitik observasional dengan pendekatan cross sectional. Didapatkan sebanyak 82 ibu yang mempunyai anak usia 12-59 bulan dalam penelitian ini menggunakan teknik simple random sampling. Data dikumpulkan memakai lembar kuesioner, kemudian dianalisis dengan chi square. Hasil penelitian menunjukkan bahwa proporsi stunting sebesar 26,8% dan tidak stunting sebesar 73,2%. Faktor yang berhubungan dengan kejadian stunting adalah berat badan lahir dan riwayat ASI eksklusif (p0,05). Faktor yang tidak berhubungan dengan kejadian stunting adalah tinggi badan ibu, pendidikan ibu, pekerjaan ibu, riwayat imunisasi, dan riwayat infeksi (p0,05). Simpulan penelitian ini faktor yang berhubungan dengan kejadian stunting yaitu berat badan lahir dan riwayat ASI eksklusif.
Influence of Covid-19 disease on hemostasis dynamics during extracorporeal membrane oxygenation (ECMO)1
Authors: Rother D. , Gehron J. , Brenck F. , Hudel H. , Böning A. , Wenzel F.
Published: December 2022

INTRODUCTION: COVID-19 causes a considerable degradation of pulmonary function to the point of an acute respiratory distress syndrome (ARDS). Over the course of the disease the gas exchange capability of the lung can get impaired to such an extent that extracorporeal membrane oxygenation (ECMO) is needed as a life-saving intervention. In patients COVID-19 as well as ECMO may cause severe coagulopathies which manifest themselves in micro and macro thrombosis. Previous studies established D-dimers as a marker for critical thrombosis of the ECMO system while on admission increased D-dimers are associated with a higher mortality in COIVD-19 patients. It is therefore crucial to determine if COVID-19 poses an increased risk of early thrombosis of the vital ECMO system. METHODS: 40 patients who required ECMO support were enrolled in a retrospective analysis and assigned into 2 groups. The COVID group consist of 20 COVID-19 patients who required ECMO support (n = 20), whereas 20 ECMO patients without COVID-19 were assigned to the control group. D-dimers, fibrinogen, antithrombin III (AT III), lactate dehydrogenase (LDH) and platelet count were analysed using locally weighted scatterplot smoothing and MANOVAs. RESULTS: The analysis of both groups shows highly significant differences in the dynamics of hemostasis. The increase in D-dimers that is associated with thrombosis of the ECMO systems occurs in COVID-19 patients around 2 days earlier (p = 2,8115 10–11) while fibrinogen is consumed steadily. In the control group fibrinogen levels increase rapidly after ten days with a plateau phase of around five days (p = 1,407 10–3) . Both groups experience a rapid increase in AT III after start of support by ECMO (p = 5,96 10–15). In the COVID group platelet count decreased from 210 giga/l to 130 giga/l within eight days, while in the same time span in the control group platelets decreased from 180 giga/l to 105 giga/l (p = 1,1 10–15). In both groups a marked increase in LDH beyond 5000 U/l occurs (p = 3,0865 10–15). CONCLUSION: The early increase in D-dimers and decrease in fibrinogen suggests that COVID-19 patients bear an increased risk of early thrombosis of the ECMO system compared to other diseases treated with ECMO. Additionally, the control group shows signs of severe inflammation 10 days after the start of ECMO which were absent in COVID-19 patients.
The Spectrum of Alzheimer-Type Pathology in Cognitively Normal Individuals
Authors: Walker Jamie M. , Dehkordi Shiva Kazempour , Schaffert Jeff , Goette William , White III Charles L. , Richardson Timothy E. , Zare Habil
Published: December 2022

Background: The strongest risk factor for the development of Alzheimer’s disease (AD) is age. The progression of Braak stage and Thal phase with age has been demonstrated. However, prior studies did not include cognitive status. Objective: We set out to define normative values for Alzheimer-type pathologic changes in individuals without cognitive decline, and then define levels that would qualify them to be resistant to or resilient against these changes. Methods: Utilizing neuropathology data obtained from the National Alzheimer’s Coordinating Center (NACC), we demonstrate the age-related progression of Alzheimer-type pathologic changes in cognitively normal individuals (CDR = 0, n = 542). With plots generated from these data, we establish standard lines that may be utilized to measure the extent to which an individual’s Alzheimer-type pathology varies from the estimated normal range of pathology. Results: Although Braak stage and Thal phase progressively increase with age in cognitively normal individuals, the Consortium to Establish a Registry for Alzheimer’s Disease neuritic plaque score and Alzheimer’s disease neuropathologic change remain at low levels. Conclusion: These findings suggest that an increasing burden of neuritic plaques is a strong predictor of cognitive decline, whereas, neurofibrillary degeneration and amyloid-β (diffuse) plaque deposition, both to some degree, are normal pathologic changes of aging that occur in almost all individuals regardless of cognitive status. Furthermore, we have defined the amount of neuropathologic change in cognitively normal individuals that would qualify them to be “resilient” against the pathology (significantly above the normative values for age, but still cognitively normal) or “resistant” to the development of pathology (significantly below the normative values for age).
E-commerce consumer behavior analysis based on big data
Authors: Lv Hua
Published: December 2022

In the background of the widespread development of big data technology, the actual behavior of e-commerce consumers is affected by different consumer environment and consumer demand. This article conducts in-depth inquiry and analysis of the behavior of different e-commerce users, and more accurately conducts a comprehensive analysis and effective assessment of various factors that affect consumer behavior. The factors and measures of consumer behavior are comprehensively judged to get the evaluation model closer to consumer behavior. By conducting a comprehensive full-process research on different e-commerce platforms, consumer behavior, consumption habits, and consumption processes, a comprehensive full-process research, more effective channel methods and dependence on consumers’ purchase of goods, conduct a comprehensive research other factors of behavior, such as transportation logistics, environmental conditions, advertising, and other factors, conduct comprehensive judgment and analysis, and provide important theoretical basis and certain research in order to promote and improve the orderly development of consumer behavior and e-commerce environment. The research adopts modeling and analysis methods, through the evaluation of the research model, it can be seen that under the background of big data, e-commerce consumer behavior presents the trend of data, diversification and complexity. Factors affecting consumer behavior are more diverse and complex. It effectively expands the research field of e-commerce consumer behavior analysis, and provides scientific reference for the development of e-commerce.
Reduced Short-Latency Afferent Inhibition in Parkinson’s Disease Patients with L-dopa-Unresponsive Freezing of Gait
Authors: Wang Lina , Ji Min , Sun Huimin , Gan Caiting , Zhang Heng , Cao Xingyue , Yuan Yongsheng , Zhang Kezhong
Published: December 2022

Background: Freezing of gait (FOG) in Parkinson’s disease (PD), especially the “L-dopa-unresponsive” subtype, is associated with the dysfunction of non-dopaminergic circuits. Objective: We sought to determine whether cortical sensorimotor inhibition evaluated by short-latency afferent inhibition (SAI) related to cholinergic and gamma-aminobutyric acid (GABA)-ergic activities is impaired in PD patients with L-dopa-unresponsive FOG (ONOFF-FOG). Methods: SAI protocol was performed in 28 PD patients with ONOFF-FOG, 15 PD patients with “off” FOG (OFF-FOG), and 25 PD patients without FOG during medication “on” state. Additionally, 10 ONOFF-FOG patients underwent SAI testing during both “off” and “on” states. Twenty healthy controls participated in this study. Gait was measured objectively using a portable Inertial Measurement Unit system, and participants performed 5-meter Timed Up and Go single- and dual-task conditions. Spatiotemporal gait characteristics and their variability were determined. FOG manifestations and cognition were assessed with clinical scales. Results: Compared to controls, PD patients without FOG and with OFF-FOG, ONOFF-FOG PD patients showed significantly reduced SAI. Further, dopaminergic therapy had no remarkable effect on this SAI alterations in ONOFF-FOG. Meanwhile, OFF-FOG patients presented decreased SAI only relative to controls. PD patients with ONOFF-FOG exhibited decreased gait speed, stride length, and increased gait variability relative to PD patients without FOG and controls under both walking conditions. For ONOFF-FOG patients, significant associations were found between SAI and FOG severity, gait characteristics and variability. Conclusion: Reduced SAI was associated with severe FOG manifestations, impaired gait characteristics and variability in PD patients with ONOFF-FOG, suggesting the impaired thalamocortical cholinergic-GABAergic SAI pathways underlying ONOFF-FOG.
Examination of muscular pain when using an innovative smartphone app for adults
Authors: Intolo Pattariya , Dailey Matthew N. , Rodamporn Somphop , Sirichaiwatjanadeacha Kodchanach , Tabhom Nattamon , Sutaro Punyavee
Published: December 2022

BACKGROUND: Smartphones are very convenient and accessible communication devices. Smartphone usage over long durations with poor posture can lead to musculoskeletal pain in adult users. OBJECTIVE: To compare pain in the neck, shoulder, upper back, lower back, arm, hand, and eye regions. METHODS: Thirty-five asymptomatic adults aged 18-25 years were divided into two groups: 1. use of an innovative smartphone app for the promotion of ergonomic behaviour (app use) and 2. no use of the innovative smartphone app (no app use). Participants sat upright, holding a smartphone with two hands, eyes 30-40 cm away from the screen, with frequent breaks consisting of stretching the neck and hand muscles while resting the eyes. The task involved taking part in online social networking for a duration of 45 minutes. A body pain chart and the visual analog scale (VAS) were used to evaluate the location and severity of pain. RESULTS: Pain in the neck, shoulder, upper back, arm, and hand regions in the “app use” condition were significantly lower than in the “no app use” condition at 15, 30, and 45 min (p-value<0.05). However, there were negligible differences between the two groups for eye pain, and lower back pain. CONCLUSION: Pain in the neck, shoulder, upper back, and arm regions in adult users in the “app use” condition was less than in the “no app use” condition. We would recommend that adults use the innovative smartphone app to prevent the risk of musculoskeletal pain potentially caused by smartphone usage.
As-Shu’ûbah al-Lughawiyyah Wafqa Haramiyyati Hector Hammerly bi Istikhdâm Moodle
Authors: Kirom Makhi Ulil
Published: December 2022

This research aims to know the linguistic difficulty of intermediate level students based on the difficulty hierarchy of Hector Hammerly (1986). By knowing the difficulty that students face, it will be easier for teacher to assign the appropriate step or method in teaching. By knowing the degrees of that difficulty, the teacher can focus attention on addressing the students' difficulty. Thus, the distribution of attention and focus in teaching a subject of grammar is balanced. The study was conducted for intermediate level students, the intensive program for teaching Arabic in the academic year 2021/2022. The researcher obtained the study data by conducting a test for the students and presented them with questions that were determined from grammatical and morphological topics, given Hammerley's classification of grammatical difficulty. The test results were obtained using the Moodle Learning Management System to facilitate the process, speed classification of results and flexibility of test for students. The researcher reached results that the grammatical difficulty of intermediate students differs according to Hammerley's hierarchical difficulty in grammatical difficulty.
FORMATION AND DEVELOPMENT OF ECOLOGICAL VISIONS IN MODERN ARCHITECTURE
Authors: Fenchuk Oleksandr
Published: December 2022

Problems related to ecology and impact on the environment in recent years have transformed our vision of ordinary things and processes. The active development of society was accompanied by a global threat - an increase in the consumption of resources, the main of which was energy. Ecology, as a discipline that is only a century and a half old, catapulted to the forefront of society in the 1960s, when an "ecological crisis" was recognized. Since then, this term appears before us both as a problem and its solution. Environmental movements and changes in social attitudes draw the attention of architects to the problems of ecology. Architecture, along with related fields, naturally reacted to these changes, developing its own way and approaches to solving the environmental problem. During the modern development of society, the problems that have become the beginning of changes in ecology grow in scale and take on new forms. However, this very development makes it possible to solve these problems more effectively. The work of international organizations and institutions is focused on preserving the environment and solving ecological problems. Measures and goals are implemented in the policies of states and cities, and ecology becomes a regulatory requirement. The general vision that considers ecology as a protected article is sustainable development - a general concept regarding the need to establish a balance between meeting the current needs of humanity and protecting the interests of future generations

On the example of the first concepts and approaches, the development of scientific and technical achievements and individual projects, it is possible to trace this process and describe the formation of an ecological approach in architecture. The article describes the process of emergence and formation of the trend of environmentalism in architecture. The key stages of the development of the problem of ecology are established and the first concepts of ecological architecture are analyzed. The main factors that influenced the emergence of ecological architecture were identified and systematized. The main goal of the study is to consider the main prerequisites for the formation of ecological views in architecture and to find peculiarities in approaches to the formation of an ecological approach. In addition, the influence of ecology on the formation of a new paradigm in architecture is considered.
DEFINITION AND HIERARCHY OF ARCHITECTURE OBJECTS BASED ON SCENARIO DESIGN METHODS
Authors: Buravchenko Serhii
Published: December 2022

Statement of the problem - a rather broad and contradictory interpretation of the concept of architectural objects has led to significant design contradictions in the real urban planning environment, the blurring of architectural tasks in the formation of buildings, complexes, ensembles and, as a result, to the loss of mechanisms for organizing the integral environment of cities.
The analysis of research and publications shows a constant interest in the definition of architectural objects. It is this process of finding and clarifying the object of architectural activity that becomes the basis for new approaches to design, the detection of non-systemic phenomena that do not contribute to the integrity of the functioning and perception of urban spaces.
The purpose of this publication is to define the concept of an architectural object based on the use of scenario methods, which cover various aspects of architectural design, which model the functional suitability, stability and reliability, and aesthetic expressiveness of the building.
The novelty of the publication lies in the use of a hierarchical system of architectural objects against the background of understanding the tasks that arise when these objects actually enter the urban environment, ensuring the sustainable development of these objects over time. .
The research methods are based on the comparative analysis of various approaches, in particular in the normative literature and the verification of the concepts of architectural objects expressed by various authors based on scenario methods and models. The result of the study is the systematization of architectural objects as a result of the creation of a hierarchical model of architectural objects. Moreover, each level of the object is designed to implement a separate part of the architectural tasks.
The identified methodological approaches and models were used in applied research aimed at improving the modern design process.
In further research, the author intends to more thoroughly analyze the theoretical works of modern architects and architectural scholars in the field of modern interpretations of architectural objects, and accordingly provide recommendations for improving the design process.
PECULIARITIES OF DOMESTIC AND FOREIGN EXPERIENCE IN SOLVING THE PROBLEM OF ARCHITECTURAL MONUMENTS THAT ARE IN THE «RUIN» STAGE
Authors: Yatsenko Victor , Kravchuk Olena
Published: December 2022

In this article, an attempt is made to consider architectural and architectural-spatial objects that are in a state of ruin as elements of resettlement, which should be offered new principles of ordering the past through the modern future.
Examples of foreign approaches to this problem are given and the existing methodology of domestic experience is considered. As a result, to justify the attempt and present the objects not as given buildings, but as elements of the systemic interaction of nature - "ruin" - a settlement system. The object of the ruin must exist as a necessary element of the spatial development of settlement systems of different levels.
The article shows the dubiousness of some methods, which predict the completion of restoration processes, and not the provision of new vital functions, which are directly related to the landscape and recreational environment and the development of an important industry for the country - tourism.
The approach when the process when the process of reconstruction, conservation, etc. involves providing it with a specific function in the future, which does not yet exist, especially one similar to the past purpose, is questionable. In the opinion of the authors, the use of a monofunction - an onal function in the future, and not a system element of resettlement - is questionable. Therefore, the question "it is impossible to restore can't be destroyed" remains open.
SCULPTURE IN MODERN INTERIOR
Authors: Grebeniuk Ivan
Published: December 2022

This work examines the issues of creation, formation and decoration of the interior space. Through the prism of subject-spatial and functional-artistic organization, sculpture is considered from a purely utilitarian activity to a form of art aimed at transforming the internal environment with integral and functional means.
Attention is drawn to the peculiarity of perception of sculpture as a form of art. The art of sculpture, reflecting the beautiful in reality, for its part, shapes our consciousness and our ideas about the beautiful. However, it is somewhat more difficult to understand sculpture than painting, which more widely, vividly and colorfully reflects the surrounding world. The brevity of the sculpture is connected with the fact that it is practically devoid of plot and relevance. Therefore, it can be considered an expression of the abstract in the concrete. Ease of perception of the sculpture is only pretend. Sculpture is symbolic, conditional and artistic, and therefore complex and deeper for perception.
In the process of life, a person is constantly in a certain physical and spatial environment. Planning, forming and transforming the design of the spatial environment, taking into account and using the revealed regularities of the construction of subject objects, relying on various theoretical and methodological developments. Creates attractive subject forms and finds original artistic techniques filled with new meaning and thereby reflects them in the world relation of the modern era.
Taking into account the growing importance of this type of design, specialists are obliged to constantly improve the ergonomic, technological, social and psychological characteristics of objects of medium design, which are formed in the process of their development, use and operation. Therefore, the sculpture can look great in any interior style. It all depends on the presentation and the composition itself.
SEARCH FOR MUSEUM ARCHITECTURE IN THE MODERN CONTEXT OF A CREATIVE CITY
Authors: Orest Hirnyi
Published: December 2022

The article is devoted to the search for optimal ideas for the transformation of National Art Museums into multifunctional cultural formations based on the modern modernization of the museum as a creative constant of the creative industry.

In the complex of tasks related to the improvement and optimization of exhibition activities, its relationship with the needs of the visitor, the theme of the formation of the architecture of complete museum buildings and the reconstruction of existing ones to ensure their dominance and communication with urban communities and creative spaces of urban historical areas is of particular importance.

In a comprehensive analysis of the ways of transformation of art museums due to the improvement of aesthetic canons and especially necessary at the time of hypertrophied globalization of the so-called "gadget contacts" to ensure real full-fledged communication within the human community and with the artistic achievements of generations at various stages of the development of societies.

The artistic image of a museum building or complex plays an important role in the interaction between the museum space and the visitor, and it is the architecture of the museum that seamlessly "draws" the visitor into the unique world of artistic heritage, introduces the concentration of creative creativity, separating it from the routine of everyday life in the city society.