bluuebunny/crossref_metadata_2025 huggingface dataset:
Cerebrospinal Fluid and Plasma Amine Profiles in Interictal Migraine
Authors: Onderwater Gerrit L. J. , van Dongen Robin M. , Harms Amy C. , Zielman Ronald , van Oosterhout Willebrordus P. J. , van Klinken Jan B. , Goeman Jelle J. , Terwindt Gisela M. , van den Maagdenberg Arn M. J. M. , Hankemeier Thomas , Ferrari Michel D.
Published: December 2022

Objective

Impaired amine metabolism has been associated with the etiology of migraine, that is, why patients continue to get migraine attacks. However, evidence from cerebrospinal fluid (CSF) is lacking. Here, we evaluated individual amine levels, global amine profiles, and amine pathways in CSF and plasma of interictal migraine patients and healthy controls.

Methods

CSF and plasma were sampled between 8:30 am and 1:00 pm, randomly and interchangeably over the time span to avoid any diurnal and seasonal influences, from healthy volunteers and interictal migraine patients, matched for age, sex, and sampling time. The study was approved by the local medical ethics committee. Individual amines (n = 31), global amine profiles, and specific amine pathways were analyzed using a validated ultraperformance liquid chromatography mass spectrometry platform.

Results

We analyzed n = 99 participants with migraine with aura, n = 98 with migraine without aura, and n = 96 healthy volunteers. Univariate analysis with Bonferroni correction indicated that CSF L‐arginine was reduced in migraine with aura (10.4%, p < 0.001) and without aura (5.0%, p = 0.03). False discovery rate‐corrected CSF L‐phenylalanine was also lower in migraine with aura (6.9%, p = 0.011) and without aura (8.1%, p = 0.001), p = 0.088 after Bonferroni correction. Multivariate analysis revealed that CSF global amine profiles were similar for both types of migraine (p = 0.64), but distinct from controls (p = 0.009). Global profile analyses were similar in plasma. The strongest associated pathways with migraine were related to L‐arginine metabolism.

Interpretation

L‐Arginine was decreased in the CSF (but not in plasma) of interictal patients with migraine with or without aura, and associated pathways were altered. This suggests that dysfunction of nitric oxide signaling is involved in susceptibility to getting migraine attacks. ANN NEUROL 2023;93:715–728
Synthesis and characterization of novel bio‐based epoxy polymers derived from natural phenolic compound
Authors: Sudprasert Pirada , Kariya Shotaro , Ogino Kenji , Chirachanchai Suwabun , Kanehashi Shinji
Published: December 2022

Bio‐based epoxy polymer was prepared from cardanol derivatives, epoxy prepolymer and phenalkamine at room temperature without solvent. Chemical structures of cured epoxy polymers were analyzed by FT‐IR and 1H NMR spectroscopy. The drying, physical, thermal, optical, and mechanical properties of the epoxy polymers were investigated in terms of the composition of epoxy and amine compounds, molecular weight of the epoxy prepolymer, and the effect of post‐curing process. The resultant epoxy polymers showed flexible nature, thermal stability (e.g., thermal decomposition temperature of 300°C). Furthermore, the epoxy polymers possessed the anti‐microbial activity against Escherichia coli and Staphylococcus aureus The molecular weight of the epoxy prepolymer also strongly affected the drying property, suggesting that the drying time can be controlled by the molecular weight of the prepolymer. Thermal treatment of the polymers as post‐curing was effective approach to improve the hardness, thermal stability, and mechanical strength. Hence, this cardanol derivatives‐based novel epoxy polymer can be expected as highly green functional epoxy polymers for coating, film and resin applications.
Patient‐ and therapist‐rated alliance predict improvements in posttraumatic stress disorder symptoms and substance use in integrated treatment
Authors: Saraiya Tanya C. , Jarnecke Amber M. , Bauer Alexandria G. , Brown Delisa G. , Killeen Therese , Back Sudie E.
Published: December 2022

Objective

Concurrent Treatment of Posttraumatic Stress Disorder (PTSD) and Substance Use Disorders Using Prolonged Exposure (i.e., COPE) is an efficacious, integrated, psychotherapy that attends to PTSD and substance use disorders simultaneously. No study has examined how therapeutic alliance functions during the provision of COPE and how this compares to non‐integrated treatments, such as relapse prevention (RP) for substance use disorders. Understanding the role of alliance in COPE versus RP could inform treatment refinement and ways to enhance treatment outcomes.

Methods

Participants (N = 55 veterans) were randomized to 12, individual, weekly sessions of COPE or RP in a randomized clinical trial. Piecewise linear mixed effect models examined how mid‐treatment (1) patient‐rated alliance, (2) therapist‐rated alliance, and (3) the convergence between patient‐ and therapist‐rated alliance as measured by a difference score predicted reductions in PTSD symptoms and substance use across treatment and follow‐up periods.

Results

Both patient‐ and therapist‐rated alliance predicted reductions in PTSD symptoms in COPE. Higher patient‐rated alliance predicted lower percent days using substances in RP. Difference score models showed higher patient‐rated alliance relative to therapist‐rated alliance scores predicted symptom reductions in COPE whereas higher therapist‐rated alliance scores relative to patient‐rated alliance scores predicted symptom reductions in RP.

Discussion

Preliminary findings show a unique relationship between the rater of the alliance and treatment modalities. Patient‐rated alliance may be important in trauma‐focused, integrated treatments whereas therapist‐rated alliance may be more important in skills‐focused, substance use interventions.
Mutualisms in a warming world: How increased temperatures affect the outcomes of multi‐mutualist interactions
Authors: Magnoli Susan M. , Keller Kane R. , Lau Jennifer A.
Published: December 2022

In nature, plant species simultaneously interact with many different mutualistic partners. These mutualists may influence one another through direct interference or indirectly by competing for shared reward resources or through alteration of plant traits. Together, these mutualists also may combine to affect plant hosts in ways that may not be predictable based on pairwise interactions. Given that the outcome of mutualistic interactions often depends on environmental conditions, multi‐mutualist effects on one another, and their plant hosts may be affected by global changes. Here, we grew focal plants under simulated global warming conditions and manipulated the presence of partner mutualists to test how warming affects the outcome of interactions between focal plants and their partners (nitrogen‐fixing rhizobia, ant defenders, and pollinators) and interactions among these partner mutualists. We find that warming alters the fitness benefits plants receive from rhizobium resource mutualists but not ant mutualists and that warming altered plant investment in all mutualists. We also find that mutualist partners interact, often by altering the availability of plant‐produced rewards that facilitate interactions with other partners. Our work illustrates that global changes may affect some but not all mutualisms, often asymmetrically (e.g., affecting investment in the mutualist partner but not plant host benefits) and also highlights the ubiquity of interactions between the multiple mutualists associating with a shared host.
Regeneration of ancient impact-scars affect regional geology worldwide
Authors: Saul John M.
Published: December 2022

The entire Earth was bombarded c.4100-3800 Ma, establishing initial
conditions for all later regional geology. Deep impact-fractures have
been regenerated upward from the brittle-ductile boundary by the action
of convection, outgassing, circulating fluids, the twice-daily
earth-tide, and earthquakes throughout all subsequent time. In
consequence, many such fractures have never entirely healed or been
eliminated. The two-dimensional map-outlines and circular curvature of
numerous three-dimensional “craterform” scars can be readily seen,
once the observer has been alerted to the possibility of their
existence. Many other Hadean/EoArchean impact-scars are covered over,
as is the case at present, at any given time. These impact features have
been regenerated “cold” from below and are fundamentally different
from astroblemes, as presently defined, whose rocks were directly
subjected to the high temperatures and pressures that accompany
hypervelocity extra-terrestrial impacts. Melt rock filled the largest
impact sites and produced cratons, with overflow producing platforms. In
later times, craton rims buckled during collisions, producing orogens.
Crater rims originally entered the Earth at near-vertical angles but
after sufficient net erosion following Snowball Earth episodes, deeply
exposed rim-zones entered the Earth at lower angles, thereby
facilitating deep subduction. Renewed activation of earliest Precambrian
fractures from below is a recurrent geological phenomenon. The
largest scar, approximately 5350 kilometers in diameter, encompasses
Asia and has Novaya Zemlya as part of an outer rim. Our vision has
greatly improved since 1788 when James Hutton could find “no vestige of
a beginning”.
Vertically aligned nanocomposite films by self‐assembled epitaxial nucleation for super‐broadband transparent conductors
Authors: Ha Youngkyoung , MacManus‐Driscoll Judith L. , Lee Shinbuhm
Published: December 2022

Designing super‐broadband transparent conductors is challenging because of the exclusive nature of conductivity and infrared transmittance. Here, using a one‐step process, we created vertically aligned nanocomposite conducting films with high transparency across a super‐broad wavelength range. Vertically aligned transparent Ba3V2O8 nanocolumns with lateral ~100‐nm widths enable high transmittance (>50%, even at a 4‐μm wavelength) for all incident light and outperform that of Sn‐doped In2O3, while the conducting SrVO3 matrix retains low resistivity (<0.56 mΩ cm at room temperature). A combined study of scanning transmission electron microscopy, scattering scanning near‐field infrared microscopy, and X‐ray diffraction revealed that spontaneous phase separation of Ba3V2O8 nanocolumns in a SrVO3 matrix film occurs via self‐assembled epitaxial nucleation. Our vertically aligned nanocomposite films provide a fertile platform for next‐generation optoelectronics.
Detection of pathological response of axillary lymph node metastasis after neoadjuvant chemotherapy in breast cancer using multiphoton microscopy
Authors: Han Zhonghua , Huang Xingxin , Kang Deyong , Fu Fangmeng , Zhang Shichao , Zhan Zhenlin , Chen Jianxin , Li Lianhuang , Wang Chuan
Published: December 2022

Neoadjuvant treatment is often considered in breast cancer patients with axillary lymph node involvement, but most of patients do not have a pathologic complete response to therapy. The detection of residual nodal disease has a significant impact on adjuvant therapy recommendations which may improve survival. Here, we investigate whether multiphoton microscopy (MPM) could identify the pathological changes of axillary lymphatic metastasis after neoadjuvant chemotherapy in breast cancer. And furthermore, we find that there are obvious differences in seven collagen morphological features between normal node and residual axillary disease by combining with a semi‐automatic image processing method, and also find that there are significant differences in four collagen features between the effective and no‐response treatment groups. These research results indicate that MPM may help estimate axillary treatment response in the neoadjuvant setting and thereby tailor more appropriate and personalized adjuvant treatments for breast cancer patients.
Fractional‐order filter‐based enhanced full state feedback control design with multi‐objective formulation using grey wolf optimization algorithm
Authors: Kumar Lalitesh , Singh Dhillon Sukhwinder , Kumar Prawendra
Published: December 2022

A perturbed fractional‐order filter (FOF)‐based LQR control design with multiple performance indices is proposed in this paper. Three variants of the FOF‐based linear quadratic regulator (LQR) system have been proposed along with choices on the commensurate order of state feedback law. The multi‐objective problem formulation has been done with three performance objectives to address the different issues of design. The first performance index constitutes a weighted sum of ITAE (Integral Time of Absolute Error) and the difference between the eigenvalues of the plant and the LQR controlled plant, chosen to minimize the large oscillations as well as relative stability with respect to eigenvalues. A new lower bound of the singular values have been addressed to ensure the robust stability of the system through the formulation of a second performance objective. It is the minimization of singular values of the return ratio matrix at the plant's input. The third and the last performance index aims minimization of maximum singular values of the perturbation transfer function at the plant's output, so as to guarantee no closed‐loop right half plane zeros. The multi‐objective optimization problem is solved and the optimal solutions are obtained via Grey Wolf Optimization Algorithm. The simulation results validate the performance and effectiveness of the proposed control design.
Transition from intensive care unit to a portable ventilator in children with severe bronchopulmonary dysplasia
Authors: McKinney Robin L. , Agarwal Amit
Published: December 2022

As the population of ventilator‐dependent children (VDC) with tracheostomies due to underlying severe bronchopulmonary dysplasia grows, there is an increasing need to shift the care of these children from hospital to home. Transitioning the ventilator‐dependent child from the hospital to home is a complex process that requires coordination between the medical team and the family. One crucial step in the process is transitioning from an Intensive care unit (ICU) ventilator to a portable home ventilator (PHV). The Clinical team needs to understand the nuances in transitioning to PHV, including assessing readiness to transition and choosing the optimum settings on an available home ventilator. In recent years, various ventilator modes have been available in PHV that can help achieve synchronous breathing to allow for adequate gas exchange for the infant. This review details some approaches to asses readiness to transition and the process of Transition along with commonly used modes of support available in PHV, as well as the primary and secondary settings in which we should be mindful in supporting a child with chronic respiratory failure in the home setting.
Children with medical complexity and pediatric palliative care: Data by a respiratory intermediate care unit
Authors: Caggiano Serena , Pavone Martino , Cherchi Claudio , Paglietti Maria Giovanna , Schiavino Alessandra , Petreschi Francesca , Chiarini Testa Maria Beatrice , Cutrera Renato
Published: December 2022

Pediatric palliative care (PPC) is an active and total approach to the care of children with life‐limiting conditions and their families. PPC programs provide ongoing treatment for children with medical complexity (CMC), many of whom will reach adulthood. Aim of the study was to describe a population of CMC attendingin six preselected months the Respiratory Intermediate Care Unit of a tertiary referral hospital for southern and central Italy. We enrolled all CMC patients admitted to our unit in six preselected months and registered pathologies and different categories of childhood diseases, devices and needs, hospitalization and home care plan. Among the 275 children admitted to our unit, 130 CMC were included. Median age was 9.9 (0.1–40.0) years. The main pathologies recorded were neuromuscular, neurological, respiratory, metabolic and malformative diseases, genetic syndromes and outcomes of prematurity. Comorbidity due to respiratory, digestive, neurological, cardiac and urological involvement was present in a high percentage of cases. Among our patients, only 46 were not carriers of any medical device. The average length of hospitalization was 7.0 (1.0–270.0) days with 2 (1.0–7.0) admissions per year per patient. Home care activation was not required for 47 out of 130 patients. Children eligible for PPC are increasing and their survival results in a rise of comorbidities and special needs demanding multilevel interventions. Respiratory symptoms are the most recurrent ones observed, thus requiring an expert in PPC with expertise in the respiratory field. Sharing data and knowledge of CMC needs may help improve care coordination.
Isolated unilateral absence of pulmonary artery (IUAPA) in adults: A case series and review of literature
Authors: Loo Yi Jia , Thomas Rajesh , Yagnik Lokesh
Published: December 2022

Unilateral Absence of Pulmonary Artery (UAPA) is a rare congenital malformation that is usually associated with cardiac anomalies. When there is no congenital cardiac abnormality it is rarer still and is termed isolated unilateral absence of pulmonary artery (IUAPA) (4). IUAPA may remain undetected until adulthood and frequently found incidentally on imaging for other indications. Symptoms are usually secondary to complications which include pulmonary hypertension, recurrent respiratory tract infections, bronchiectasis and haemoptysis. We report two cases with widely contrasting presentation and trajectories, leading to individualized management strategies.
Patterns and Predictors of Stranger Rape Locations
Authors: Lundrigan Samantha , Weir Ruth , Newton Andrew , Agudelo Kelly , Dhami Mandeep
Published: December 2022

This paper examines the spatial, environmental, and temporal patterns of 10,488 stranger rapes committed over a 15-year period in Greater London, UK. We distinguished between two types of stranger rapes according to perpetrator method of approach, i.e. absent/fleeting interaction with victim on approach (S1) or extended interaction with victim on approach (S2). There were a range of locational settings in which perpetrators both encountered their victims and where the offence took place, and these differed by method of approach. The highest number of S1 offences occurred outdoors, with 74% of approaches and 55% of offences located recorded as outside. For S2 rapes, there was more variety in approach locations with only 32% outside. The level of locational correspondence between approach and offence location was 71% for S1 rapes and 28% for S2 rapes. A series of negative binomial regression models identified variables predictive of stranger rape offence location. There were significant associations with transport connections and the night-time economy for both S1 and S2 rapes. Other significant predictors were deprivation score, the percentage of one person properties, and the percentage of private rented properties in a location. The percentage of green space was a significant predictor for S1 rapes only. The current findings challenge the popular narrative that stranger rape occurs in a specific setting (i.e. outside in a secluded location at night) and have implications for place-based crime prevention policy.
Analysis of Visual Characteristics of Short-circuited Arc Sites
Authors: Hong Seongjun , Bang Sun-bae , Bang Jun-ho , Park Jinyoung , Min Ki-deuk , Lee Jin-sik
Published: December 2022

Identifying the cause of fire at a fire site is an important fire prevention measure to prevent recurrence. In particular, information about molten marks of the copper wire is essential to check whether electric power is being supplied at the fire site. This study aims to analyse the visual characteristics of arc sites formed by a short circuit to identify the molten marks at the fire site. When a short circuit occurs, electromagnetic force is generated by the short circuit current, and the arc repulsion force is generated by the contact arc. In this study, the effects of the forces, which act on the short-circuited melted area, on the formation of copper molten marks were investigated. Copper molten marks formed by a short circuit were experimentally fabricated, and the visual characteristics based on the force that was applied to the melted area were identified and classified based on features. The results showed that the melted area was affected by both the arc repulsion and electromagnetic forces, resulting in the visual differences between the short-circuited arc sites and flame-melted ones, which are affected by gravity and molecular force. These results provide a theoretical basis for discriminating between arc sites formed by a short circuit and flame-melted marks at the fire site. The validity of this study was verified via a comparative analysis using shape and cross-sectional microstructure of molten marks collected at the fire site.
Potential to improve nitrogen use efficiency (NUE) by use of perennial mobile green manures
Authors: Ward C. R. , Chadwick D. R. , Hill P. W.
Published: December 2022

Supplying nitrogen (N) to crops by incorporating N2-fixing green manures into soil can improve soil functioning and increase soil carbon storage. However, as with N-fertiliser use, excess mineral N from decomposed green manures can be lost via leaching as NO3− and emitted as the greenhouse gas N2O. To improve nitrogen use efficiency (NUE) we propose supplying leaf matter harvested from permanent stands of N2-fixing plants grown ex-situ as perennial mobile green manures (PMGMs), thus allowing flexible timing of additions to synchronise with N demand. To assess the effectivity of PMGM use, we monitored crop N uptake, biomass production and soil mineral N from fertilisation by three potential PMGM species, Alnus glutinosa (alder), Gunnera tinctoria (gunnera), and Ulex europaeus (gorse), compared to the conventional green manure Trifolium pratense (red clover) and NH4NO3 fertiliser. Effectivity of N fertilisation by PMGMs increased with the duration of their use. In the first season of a field experiment, crop N uptake after addition of 200 kg N ha−1 within gunnera was equivalent to that from only 14 kg NH4NO3-N ha−1, but after two yearly harvests with annual gunnera additions it increased to 70 kg NH4NO3-N ha−1 year−1 equivalent. In a 1-year pot experiment, PMGMs resulted in equal or higher crop biomass than clover-fed crops, with lower soil NO3− (≤ 25 mg N L−1 soil solution) than in clover-treated soil (≥ 130 mg N L−1). We conclude that PMGMs have potential to increase NUE over that of traditional green manures and discuss the feasibility and possible agro-ecological benefits of PMGM-fed systems.
Examining the Relationship of Clergy Distress, Spiritual Well-Being, Stress Management and Irritation to Life Satisfaction among Black Pastors in the USA
Authors: Rogers Robert C.
Published: December 2022

This study sought to determine the level of clergy distress and other psychological characteristics of Black pastors and their relationship to life satisfaction through a convenience sample of 2786 Black pastors in historically Black Protestant denominations and nondenominational Black churches. The response rate equaled 10.1% (283/2786) while the survey completion rate equaled 77% (218/283). These 218 Black pastors were serving as either senior pastors (86.3%) or co-pastors (13.7%). This study found clergy distress in Black pastors did not differ based on gender or age but differed by church size and denomination. Clergy distress (r =  − .187, p = .023) and irritation (r =  − .293, p = .003) possessed significant relationships with satisfaction with life as expected, but stress management (r = .039, p = .641), spiritual well-being in daily life (r = .140, p = .140), and spiritual well-being in ministry (r =  − .064, p = .475) did not, which was surprising. Notably strong relationships existed between stress management and spiritual well-being in daily life (r = .469, p = .003) and stress management and irritation (r =  − .359, p = .003). These two important relationships may offer some guideposts for Black pastors in developing strategies to combat the impact of both clergy distress and irritation. The study concludes with implications for Black pastors and suggestions for future research.
The lattice of one-sided congruences on an inverse semigroup
Authors: Brookes Matthew D. G. K.
Published: December 2022

We build on the description of left congruences on an inverse semigroup in terms of the kernel and trace due to Petrich and Rankin. The notion of an inverse kernel for a left congruence is developed. Various properties of the trace and inverse kernel are discussed, in particular that the inverse kernel is a full inverse subsemigroup and that both the trace and inverse kernel maps are onto$$\cap $$∩-homomorphisms. It is shown that a left congruence is determined by its trace and inverse kernel, and the lattice of left congruences is identified as a subset of the direct product of the lattice of congruences on the idempotents and the lattice of full inverse subsemigroups. We demonstrate that every finitely generated left congruence is the join of a finitely generated trace minimal left congruence and a finitely generated idempotent separating left congruence. Characterisations are given of inverse semigroups that are left Noetherian, or are such that Rees left congruences are finitely generated.
Assessing nuclear versus mitochondrial cell-free DNA (cfDNA) by qRT-PCR and droplet digital PCR using a piglet model of perinatal asphyxia
Authors: Bitenc Marie , Grebstad Tune Benedicte , Melheim Maria , Atneosen-Åsegg Monica , Lai Xiaoran , Rajar Polona , Solberg Rønnaug , Baumbusch Lars Oliver
Published: December 2022

Background

Since the discovery more than half a century ago, cell-free DNA (cfDNA) has become an attractive objective in multiple diagnostic, prognostic, and monitoring settings. However, despite the increasing number of cfDNA applications in liquid biopsies, we still lack a comprehensive understanding of the nature of cfDNA including optimal assessment. In the presented study, we continued testing and validation of common techniques for cfDNA extraction and quantification (qRT-PCR or droplet digital PCR) of nuclear- and mitochondrial cfDNA (ncfDNA and mtcfDNA) in blood, using a piglet model of perinatal asphyxia to determine potential temporal and quantitative changes at the levels of cfDNA.

Methods and Results

Newborn piglets (n = 19) were either exposed to hypoxia (n = 11) or were part of the sham-operated control group (n = 8). Blood samples were collected at baseline (= start) and at the end of hypoxia or at 40–45 min for the sham-operated control group. Applying the qRT-PCR method, ncfDNA concentrations in piglets exposed to hypoxia revealed an increasing trend from 7.1 ng/ml to 9.5 ng/ml for HK2 (hexokinase 2) and from 4.6 ng/ml to 7.9 ng/ml for β-globulin, respectively, whereas the control animals showed a more balanced profile. Furthermore, median levels of mtcfDNA were much higher in comparison to ncfDNA, but without significant differences between intervention versus the control group.

Conclusions

Both, qRT-PCR and the droplet digital PCR technique identified overall similar patterns for the concentration changes of cfDNA; but, the more sensitive digital PCR methodology might be required to identify minimal responses.
Automatic model training under restrictive time constraints
Authors: Cironis Lukas , Palczewski Jan , Aivaliotis Georgios
Published: December 2022

We develop a hyperparameter optimisation algorithm, Automated Budget Constrained Training, which balances the quality of a model with the computational cost required to tune it. The relationship between hyperparameters, model quality and computational cost must be learnt and this learning is incorporated directly into the optimisation problem. At each training epoch, the algorithm decides whether to terminate or continue training, and, in the latter case, what values of hyperparameters to use. This decision weighsoptimallypotential improvements in the quality with the additional training time and the uncertainty about the learnt quantities. The performance of our algorithm is verified on a number of machine learning problems encompassing random forests and neural networks. Our approach is rooted in the theory of Markov decision processes with partial information and we develop a numerical method to compute the value function and an optimal strategy.
Probabilistic modeling of sustainable urban drainage systems
Authors: Raimondi A. , Di Chiano M. G. , Marchioni M. , Sanfilippo U. , Becciu G.
Published: December 2022

Sustainable Urban Drainage Systems (SUDS) include strategies and solutions for distributed stormwater management and control. They are strongly encouraged, especially in highly urbanized areas that suffer the combined effect of impervious surfaces and the increase in extreme rainfall events due to urbanization growth and climate change. Their integration into traditional urban drainage systems can mitigate flood risk and pollution of receiving water bodies. The main goal of SUDS is to restore the natural water balance by increasing infiltration and evapotranspiration processes and promoting rainwater harvesting and reuse. This paper proposes an analytical-probabilistic approach for SUDS modeling applicable to different systems. Developed equations allow estimating the runoff and residual storage probability for evaluating the efficiency of the storage volume both in terms of flood control and, depending on SUDS type, in terms of emptying time or water needs supply. The modeling considers the possibility of consecutive chained rainfalls; this feature is relevant for SUDS, often characterized by low outflow rates. Relating characteristic parameters to a probabilistic level (the Average Return Interval, ARI) makes the formulas interesting to be used in the design practice. An application to two case studies confirmed the goodness of the proposed method.
Global reconstruction of language models with linguistic rules – Explainable AI for online consumer reviews
Authors: Binder Markus , Heinrich Bernd , Hopf Marcus , Schiller Alexander
Published: December 2022

Analyzing textual data by means of AI models has been recognized as highly relevant in information systems research and practice, since a vast amount of data on eCommerce platforms, review portals or social media is given in textual form. Here, language models such as BERT, which are deep learning AI models, constitute a breakthrough and achieve leading-edge results in many applications of text analytics such as sentiment analysis in online consumer reviews. However, these language models are “black boxes”: It is unclear how they arrive at their predictions. Yet, applications of language models, for instance, in eCommerce require checks and justifications by means of global reconstruction of their predictions, since the decisions based thereon can have large impacts or are even mandatory due to regulations such as the GDPR. To this end, we propose a novel XAI approach for global reconstructions of language model predictions for token-level classifications (e.g., aspect term detection) by means of linguistic rules based on NLP building blocks (e.g., part-of-speech). The approach is analyzed on different datasets of online consumer reviews and NLP tasks. Since our approach allows for different setups, we further are the first to analyze the trade-off between comprehensibility and fidelity of global reconstructions of language model predictions. With respect to this trade-off, we find that our approach indeed allows for balanced setups for global reconstructions of BERT’s predictions. Thus, our approach paves the way for a thorough understanding of language model predictions in text analytics. In practice, our approach can assist businesses in their decision-making and supports compliance with regulatory requirements.
Freud, Jung, and Jonah
Authors: Katz Maya Balakirsky
Published: December 2022

Religion, more than sexuality, cast psychoanalysis in controversy and onto the world stage even as it threatened to dismantle the psychoanalytic collective. In the founding years of the first psychoanalytic periodicals, relational dynamics shaped the psychoanalytic corpus on religion. The psychoanalytic pioneers developed their ideas in tandem even if in protest to one another. Religion is a topic worthy of engagement, not least because the symbolized terrain in the history of religion was so often deployed as a vehicle for motivating, disciplining, or editing out a member of the psychoanalytic community in publication. This book offers an interdisciplinary approach to religion and psychology, including a compelling denouement that reveals new narratives about longstanding rumours in the early history of the psychoanalytic movement. Above all, this volume demonstrates that the first generation of psychoanalysts succeeded in writing themselves into the history of religious thought and sacralizing the origins of psychoanalysis.
Meno and the Slave
Authors: Nathan A. R.
Published: December 2022

This paper argues that the slave demonstration in Plato'sMenocontains a carefully-wrought analogy of Meno's dialectic which can guide our understanding of the dialogue. This analogy exposes and diagnoses Meno's failings as a student who is unwilling to engage in the learning process but simply wants to be spoon-fed information. This, in turn, reveals the way Plato wants us to interact with his text: insofar as the author makes his point implicitly and allusively, we are aptly required to puzzle our way through the text to unravel the meaning. We must actively engage with the text. TheMeno, thus, exemplifies its own didactic message. In this way, I hope to offer a meaningful interpretation of a significant passage in Plato as well as provide a case study of how he can marshal the literary resources at his disposal towards his philosophical ends.
Phaeophyscia kashmirensis sp. nov. (Lecanorales, Physciaceae) from Azad Jammu and Kashmir, Pakistan
Authors: Fayyaz Iram , Afshan Najam-ul-Sehar , Khalid Abdul Nasir
Published: December 2022

A new species in the genus Phaeophyscia is described from Azad Jammu and Kashmir, Pakistan, supported by nrITS sequences, morphology and chemistry. The taxon is characterized by a green to greyish green thallus, usually narrow (0.5–2 mm), flat to convex lobes with abundant marginal soralia, black, dense small rhizines, small Physcia-type ascospores 18–22 × 8–10 μm and an absence of pycnidia. Differences from related species are discussed.
The regulation of religion in public spaces
Authors: Thompson Simon
Published: December 2022

A number of controversial aspects of the relationship between religion and the state are located in public space. Although burqa bans, the Swiss minaret ban, and duties to display crucifixes on public buildings are different in various ways, it is significant that they all take place in this particular type of location. However, when normative political theorists have addressed these issues, they have rarely paid sufficient attention to their spatial location, and, as a result, their analyses are lacking a vital dimension. This article shows what can go wrong when these normative analyses do not refer to an account of public space. It then indicates what part of a suitable account would look like by sketching four of its essential elements, referred to as the definition, distinctiveness, differentiation, and dynamism of public space. It is argued that normative political theorists should draw on aspects of such an account in order to achieve a more sophisticated understanding of issues concerning religion in public spaces, as well as to reach more securely grounded normative conclusions about them.
Deliberative constitutionalism ‘without shortcuts’: On the deliberative potential of Cristina Lafont’s judicial review theory
Authors: Guiffré C. Ignacio
Published: December 2022

Deliberative constitutionalism is one of the most important developments of recent decades in constitutional theory and practice. It is in this context that Cristina Lafont’sDemocracy Without Shortcutswas published. Lafont’s theory provides an opportunity to advance the research agenda on deliberative constitutionalism since she offers a deliberative democratic reinterpretation of judicial review. According to this compelling and powerful idea, citizens can challenge any laws in constitutional courts and thus trigger democratic deliberation about rights. With this issue in mind, this article offers a general approach to deliberative constitutionalism, describes Lafont’s reinterpretation of judicial review, and makes explicit five tensions in this reinterpretation of judicial reviewvis-à-visdeliberative constitutionalism: (1) the default authority in the interim; (2) the procedural type of constitutional amendment; (3) the scope of judicial review; (4) the irrelevance of constitutional amendments; and (5) the scope of constituent power.
TEXTS RELATING TO THE DEATH OF MATILDA DE BAILLEUL, ABBESS OF WHERWELL: ST. PETERSBURG, NATIONAL LIBRARY OF RUSSIA, MS LAT.Q.V.I.62, FOL. 12V
Authors: ARBABZADAH MOREED
Published: December 2022

This article offers the first full edition, translation, and commentary for three Latin texts relating to the death of Matilda de Bailleul (d. 1212), a Flemish abbess of Wherwell, a Benedictine abbey in Hampshire, England. Wherwell was relatively prosperous throughout its history and was probably founded in the tenth century by Queen Ælfthryth, wife of King Edgar. All three texts appear on the final verso (fol. 12v) of St. Petersburg, National Library of Russia, MS Lat.Q.v.I.62. The manuscript comprises two quires: the first contains a liturgical calendar; the second contains computistic and musical material, followed by the texts relating to Matilda's death. The calendar was made at St. Albans in the middle of the twelfth century and had reached Wherwell by 1189 or soon afterwards. The second quire could have been added at either St. Albans or Wherwell. The first two texts are short poems which commemorate Matilda in elegiac couplets. The third text is a letter of consolation on the death of Matilda, from Guy, prior of Southwick, to Euphemia de Walliers (or Wallers), prioress of Wherwell, who was Matilda's niece and successor as abbess of Wherwell. For the first time, evidence is identified which indicates that the two poems were written by different authors. Errors in previous editions of the poems and letter are corrected. Explanations are offered for numerous passages that are difficult to interpret, many of which have hitherto received no comment. Parallels are frequently cited for passages in Guy of Southwick's letter, thereby showing his influences and the extent to which his letter stitches together and reworks quotations from both the Bible and other sources.
EQUUM ET RATIONABILE EST: EXTENSIÓN Y USOS DE UN PREÁMBULO DE MEMORIA EN LA CIUDAD DE OVIEDO (SIGLOS XII—XIII)
Authors: CALLEJA-PUERTA MIGUEL
Published: December 2022

Este trabajo explica los orígenes y evolución de un preámbulo diplomático que fue común en los documentos de compraventa y donación que se redactaban entre mediados del siglo XII y mediados del XIII en la ciudad de Oviedo, al norte del antiguo reino de León. Merece estudio por su larga perduración en el tiempo, ya que fue pasando de unos escribanos a otros y alcanzó la época de la implantación del notariado público. Asimismo, interesa desde el punto de vista lingüístico, ya que comenzó su trayectoria como una composición latina que, en una fase avanzada de su trayectoria, dio lugar a una fórmula romance original. Pero sobre todo llama la atención por la extrañeza de hallar un discurso estructurado sobre las ideas de equitas y ratio en una zona con vida urbana débil, carente de instituciones de enseñanza sólidas, y en general considerada periférica en el reino, más aún a escala europea. En fin, el modo en que habla de la memoria puede aportar matices interesantes a un objeto de estudio que en la Edad Media leonesa ha buscado más la crítica de autenticidad de los cartularios, y luego la comprensión de los mismos, que el papel de lo escrito en la conformación de los derechos de propiedad.
THE WRITINGS OF NICOLE ORESME: A SYSTEMATIC INVENTORY
Authors: DI LISCIA DANIEL A. , PANZICA AURORA
Published: December 2022

This paper provides an up-to-date inventory of the works of Nicole Oresme (ca. 1320–1382). For each text, we present the incipit and the explicit, its (approximate) date, the list of manuscripts, and, whenever possible, editions and translations. We also inventory self-references contained in Oresme's writings and discuss specific problems concerning their titles, attributions, and textual transmission. Oresme's works are classified into nine groups, for each of which we offer preliminary remarks to situate the group in the context of Oresme's career. The two appendices provide detailed information about two texts of possible Oresmian attribution.
Pathogenic REST variant causing Jones syndrome and a review of the literature
Authors: Rahikkala Elisa , Julku Johanna , Koskinen Sari , Keski-Filppula Tommi , Weissgraeber Stephanie , Bertoli-Avella Aida M. , Häkli Sanna , Kraatari-Tiri Minna
Published: December 2022

Jones syndrome is a rare dominantly inherited syndrome characterized by gingival fibromatosis and progressive sensorineural hearing loss becoming symptomatic in the second decade of life. Here, we report a father and his two daughters presenting with a typical Jones syndrome (OMIM %135550) phenotype. Exome sequencing identified a repressor element 1-silencing transcription factor (REST, OMIM *600571) (NM_005612.5) c.2670_2673del p.(Glu891Profs*6) heterozygous variant segregating with Jones syndrome in the family. We review the clinical data from all previously published patients with Jones syndrome and previously published patients with pathogenic REST variants associated with gingival fibromatosis or sensorineural hearing loss. This study suggests that pathogenic REST variants cause Jones syndrome.
Energy absorbed from double quantum dot-metal nanoparticle hybrid system
Authors: Akram Haneen , Abdullah Muwaffaq , Al-Khursan Amin H.
Published: December 2022

This work proposes the double quantum dot (DQD)-metal nanoparticle (MNP) hybrid system for a high energy absorption rate. The structure is modeled using density matrix equations that consider the interaction between excitons and surface plasmons. The wetting layer (WL)-DQD transitions are considered, and the orthogonalized plane wave (OPW) between these transitions is considered. The DQD energy states and momentum calculations with OPW are the figure of merit recognizing this DQD-MNP work. The results show that at the high pump and probe application, the total absorption rate $$({Q}_{tot})$$

(

Q

tot

)

of the DQD-MNP hybrid system is increased by reducing the distance between DQD-MNP. The high $${Q}_{tot}$$

Q

tot

obtained may relate to two reasons: first, the WL washes out modes other than the condensated main mode. Second, the high flexibility of manipulating DQD states compared to QD states results in more optical properties for DQD. The $${Q}_{DQD}$$

Q

DQD

is increased at a small MNP radius on the contrary to the $${Q}_{MNP}$$

Q

MNP

which is increased at a wider MNP radius. Under high tunneling, a broader blue shift in the $${Q}_{tot}$$

Q

tot

due to the destructive interference between fields is seen and the synchronization between $${Q}_{MNP}$$

Q

MNP

and $${Q}_{DQD}$$

Q

DQD

is destroyed. $${Q}_{tot}$$

Q

tot

for the DQD-MNP is increased by six orders while $${Q}_{DQD}$$

Q

DQD

is by eight orders compared to the single QD-MNP hybrid system. The high absorption rate of the DQD-MNP hybrid system comes from the transition possibilities and flexibility of choosing the transitions in the DQD system, which strengthens the transitions and increases the linear and nonlinear optical properties. This will make the DQD-MNP hybrid systems preferable to QD-MNP systems.
External pressure dynamics promote kidney viability and perfusate filtration during ex vivo kidney perfusion
Authors: Higashi Yuhei , Homma Jun , Sekine Hidekazu , Yago Hiroki , Kobayashi Eiji , Shimizu Tatsuya
Published: December 2022

Normothermic machine perfusion (NMP) has not yet been established as a technique for preserving organs for a day. A key contributing factor to the same is that the perfusing solutions cannot circulate continuously and evenly in the organs. Here, we conceived a method of applying intermittent air pressure from outside the organ to assist its circulatory distribution during perfusion. We used a perfusion culture system while applying external pressure to culture rat kidneys and compared the circulatory distribution in the kidneys, changes in tissue morphology due to injury, and perfusate filtration. The intermittent pressurization (IMP) (−) group showed markedly poorer circulation on the upper side compared with that in the lower side, alongside histological damage. On the other hand, the IMP (+) group showed improved circulation in the upper side and had lesser histological damage. Furthermore, the IMP (+) group maintained the ability to filter perfusate for 24 h. In transplantation medicine and regenerative medicine research, this method has the potential to contribute to more efficient organ preservation and more functional tissue regeneration in the future.
Lock-in amplifier based peak force infrared microscopy
Authors: Dorsa Andrea , Xie Qing , Wagner Martin , Xu Xiaoji G.
Published: December 2022

Peak Force Infrared (PFIR) microscopy enables label-free chemical imaging with a spatial resolution below Abbe's diffraction limit through the integration of atomic force microscopy and infrared radiation.
Visible-light-induced synthesis of N-disulfanyl indoles, pyrroles or carbazoles via the construction of stable S–S–N bonds
Authors: Lao Tianfeng , Chen Jianxin , Zhou Xianhang , Zhang Ziwu , Cao Gao , Su Zhengquan , Yu Yue , Cao Hua
Published: December 2022

A simple and efficient visible-light-induced protocol for disulfuration of indoles, pyrroles or carbazoles with trisulfide oxides has been developed.
Real-space visualization of sequential debromination of polybrominated benzenes on Ag(111)
Authors: Shang Lina , Gao Wenze , Kang Faming , Zhang Zhaoyu , Zhang Chi , Xu Wei
Published: December 2022

By a combination of scanning tunneling microscopy imaging and density functional theory calculations, dehalogenation processes of symmetric polyhalogenated benzenes were explored on Ag(111), with sets of intermediate states visualized in real space.
Direct synthesis of IDM-1 aluminosilicate nanosheets with improved MTP performance
Authors: Gong Yudan , Tuo Jie , Li Shiqing , Zhao Yuhong , Xu Hao , Guan Yejun , Jiang Jingang , Wu Peng
Published: December 2022

Through a preliminary aging treatment, Al-I1 nanosheets were achieved with changeable b-axis thicknesses of 40–200 nm and exhibited superior catalytic performance in the MTP reaction.
Achieving high quantum capacitance graphdiyne through doping and adsorption
Authors: Yang Guangmin , Li Zhuo , Wang Siqi , Lin Jianyan
Published: December 2022

Graphdiyne (GDY) has attracted extensive attention in the field of energy storage. The effects of doping B, N, P, S atoms and adsorbing Au, Ag, Cu, Ti, Al metal atoms on the quantum capacitance of GDY are systematically investigated.
Spontaneous emergence of enantioenriched chiral aldol reaction products from Achiral precursors in solution and origin of biological homochirality of sugars: a first-principles study
Authors: Mauksch Michael
Published: December 2022

An aldol reaction product, formed from achiral precursors and without external chiral source, exhibits spontaneous mirror symmetry breaking under non-equilibrium conditions, when reactants are provided initially in non-stoichiometric molar quantities.
Superconductivity of monolayer functionalized biphenylene with Dirac cones
Authors: Liu Guo-Hua , Yang Liu , Qiao Shu-Xiang , Jiao Na , Chen Ying-Jie , Ni Mei-Yan , Zheng Meng-Meng , Lu Hong-Yan , Zhang Ping
Published: December 2022

The superconducting critical temperature Tc of biphenylene can be pushed from 0.59 K to 3.91 K after Li deposition. Biaxial tensile strain can soften phonons and further increase Tc up to 15.86 K at ε = 12% tensile strain in Li-deposited biphenylene.