bluuebunny/crossref_metadata_2025 huggingface dataset:
Does smoking cessation affect postoperative healing following oral surgery among smokers? – a systematic review
Authors: Olsson Magnus , Nordendahl Eva , Klinge Björn , Ekbom Anders , Edlund Christoffer , Fored Michael , Sundström Johan , Naimi-Akbar Aron
Published: February 2024

Background

It is well documented that smokers suffer increased risk of postoperative complications after medical surgery, for example delayed healing and increased risk of infection. It is also known that preoperative smoking cessation can reduce the risk of these complications. Because of this there are guidelines regarding preoperative smoking cessation in non-oral medical surgery. There are however no specific guidelines regarding oral surgical procedures, such as surgical extractions, dentoalveolar surgery, periodontal surgery, or dental implantation. Nevertheless, it is common that dentists and oral surgeons recommend smoking cessation pre to oral surgical procedures. The aim with this systematic review was to see if there are any evidence in the literature, supporting preoperative smoking cessation in oral surgical procedures.

Methods

A systematic search of the electronic databases PubMed, Scopus, Web of Science, and Cochrane was conducted to identify studies addressing the effect of preoperative smoking cessation in oral surgical procedures. Included publications were subjected to preidentified inclusion criterion. Six examiners performed the eligibility and quality assessment of relevant studies. Risk of bias was assessed using ROBINS-I and RoB 2. Certainty assessment was carried out using GRADE.

Results

The initial search resulted in 2255 records, and after removal of 148 duplicates, 16 articles met an acceptable level of relevance. These were read in full text, whereof 12 articles were excluded, due to different intervention, outcome, or study design than stated in the review protocol. One study remained with moderate risk of bias and three were excluded due to high risk of bias.

Conclusion

This systematic review could not determine the effect of smoking cessation pre to oral surgical procedures, in smokers. This indicates lack of knowledge in the effects of smoking cessation. We also conclude a lack of knowledge in how to design smoking cessation in the most effective way.
A training program for improving the capacity of infection high-throughput sequencing and diagnosis in China
Authors: Zhang Dong , Cheng Yunfeng , Ji Yuan , Miao Qing , Chen Bojiang , Wang Jing , Wu Guoqiu , Yuan Chenyan , Zheng Guangjuan , Liu Han , Qiu Xinmin , Gong Jie , Ba Hongping , Pan Liping , Ma Xiaoling , Qi Yingjie , Shi Yuru , Zhang Qi , Li Dan , Xu Yingchun
Published: February 2024

Background

Infectious diseases are a serious threat to human especially since the COVID-19 outbreak has proved the importance and urgency of their diagnosis and treatment again. Metagenomic next-generation sequencing (mNGS) has been widely used and recognized in clinical and carried out localized testing in hospitals. Increasing the training of mNGS detection technicians can enhance their professional quality and more effectively realize the application value of the hospital platform.

Methods

Based on the initial theoretical understanding and practice of the mNGS platform for localization construction, we have designed a training program to enhance the ability of technicians to detect pathogens by utilizing mNGS, and hence to conduct training practices nationwide.

Results

Until August 30, 2022, the page views of online classes have reached 51,500 times and 6 of offline small-scale training courses have been conducted. A total of 67 trainees from 67 hospitals have participated in the training with a qualified rate of 100%. After the training course, the localization platform of 1 participating hospital has been put into use, 2 have added the mNGS localization platform for admission, among which 3 have expressed strong intention of localization.

Conclusions

This study focuses on the training procedures and practical experience of the project which is the first systematic standardized program of mNGS in the world. It solves the training difficulties in the current industry, and effectively promotes the localization construction and application of mNGS in hospitals. It has great development potential in the future and is worth further promotion.
Creation of a rating scale to teach Less Invasive Surfactant Administration (LISA) in simulation
Authors: Rostoker Hélène , Guillois Bernard , Caradec Amaya , Lecomte François , Oriot Denis , Chollat Clément
Published: February 2024

Background

Simulation-based training is gaining increasing prominence in neonatology training. The Less Invasive Surfactant Administration (LISA) method is starting to be taught in simulation. The aim of this educational study was to develop and validate a rating scale for teaching the LISA method in simulation.

Methods

The Downing framework was used to create this performance-rating scale. A first version of the scale was submitted to 12 French and Belgian experts to obtain their opinions. Consensus was reached using a modified Delphi method. The performance of 40 pediatricians was then evaluated with this scale on a preterm neonate manikin simulating a neonatal respiratory distress syndrome. Each run was evaluated using the scale by two independent observers based on video recordings.

Results

The Cronbach alpha score of the rating scale was 0.72. The intraclass correlation coefficient (ICC) was 0.91 and the scores between raters were not significantly different. Finally, this rating scale correctly distinguished the experienced from the inexperienced learners (p < 0.01).

Conclusions

This rating scale is one of the first rating scales for the evaluation and teaching of the LISA method in simulation. This tool has ample potential for use in clinical practice to evaluate the performance of surfactant administration in preterm neonates.
Which risk factor best predicts coronary artery disease using artificial neural network method?
Authors: Azdaki Nahid , Salmani Fatemeh , Kazemi Toba , Partovi Neda , Bizhaem Saeede Khosravi , Moghadam Masomeh Noori , Moniri Yoones , Zarepur Ehsan , Mohammadifard Noushin , Alikhasi Hassan , Nouri Fatemeh , Sarrafzadegan Nizal , Moezi Seyyed Ali , Khazdair Mohammad Reza
Published: February 2024

Background

Coronary artery disease (CAD) is recognized as the leading cause of death worldwide. This study analyses CAD risk factors using an artificial neural network (ANN) to predict CAD.

Methods

The research data were obtained from a multi-center study, namely the Iran-premature coronary artery disease (I-PAD). The current study used the medical records of 415 patients with CAD hospitalized in Razi Hospital, Birjand, Iran, between May 2016 and June 2019. A total of 43 variables that affect CAD were selected, and the relevant data was extracted. Once the data were cleaned and normalized, they were imported into SPSS (V26) for analysis. The present study used the ANN technique.

Results

The study revealed that 48% of the study population had a history of CAD, including 9.4% with premature CAD and 38.8% with CAD. The variables of age, sex, occupation, smoking, opium use, pesticide exposure, anxiety, sexual activity, and high fasting blood sugar were found to be significantly different among the three groups of CAD, premature CAD, and non-CAD individuals. The neural network achieved success with five hidden fitted layers and an accuracy of 81% in non-CAD diagnosis, 79% in premature diagnosis, and 78% in CAD diagnosis. Anxiety, acceptance, eduction and gender were the four most important factors in the ANN model.

Conclusions

The current study shows that anxiety is a high-prevalence risk factor for CAD in the hospitalized population. There is a need to implement measures to increase awareness about the psychological factors that can be managed in individuals at high risk for future CAD.
Evaluation of the telemedical health care network “SAFE BIRTH” for pregnant women at risk, premature and sick newborns and their families: study protocol of a cluster-randomized controlled stepped-wedge trial
Authors: Hense Helene , Mathiebe Josephine , Helfer Sven , Glaubitz Rick , Rüdiger Mario , Birdir Cahit , Schmitt Jochen , Müller Gabriele
Published: February 2024

Background

The Perinatal Center of the University Hospital Carl Gustav Carus Dresden has initiated the telemedical healthcare network “SAFE BIRTH” to coordinate and improve specialized care in non-metropolitan regions for pregnant women and newborns. The network incorporates five intervention bundles (IB): (1) Multi-professional, inter-disciplinary prenatal care plan; (2) Neonatal resuscitation; (3) Neonatal antibiotic stewardship; (4) Inter-facility transfer of premature and sick newborns; (5) Psycho-social support for parents. We evaluate if the network improves care close to home for pregnant women, premature and sick newborns.

Methods

To evaluate the complex healthcare intervention “SAFE BIRTH” we will conduct a cluster-randomized controlled stepped-wedge trial in five prenatal medical outpatient offices and eight non-metropolitan hospitals in Saxony, Germany. The offices and hospitals will be randomly allocated to five respectively eight sequential steps over a 30-month period to implement the telemedical IB. We define one specific primary process outcome for each IB (for instance IB#1: “Proportion of patients with inclusion criterion IB#1 who have a prenatal care plan and psychosocial counseling within one week”). We estimated a separate multilevel logistic regression model for each primary process outcome using the intervention status as a regressor (control or intervention group). Across all IB, a total of 1,541 and 1,417 pregnant women or newborns need to be included in the intervention and control group, respectively, for a power above 80% for small to medium intervention effects for all five hypothesis tests. Additionally, we will assess job satisfaction and sense of safety of health professionals caring for newborns (questionnaire survey) and we will assess families’ satisfaction, resilience, quality of life and depressive, anxiety and stress symptoms (questionnaire surveys). We will also evaluate the cost-effectiveness of ”SAFE BIRTH” (statutory health insurance routine data, process data) and barriers to its implementation (semi-structured interviews). We use multilevel regression models adjusting for relevant confounders (e.g. socioeconomic status, age, place of residence), as well as descriptive analyses and qualitative content analyses.

Discussion

If the telemedical healthcare network “SAFE BIRTH” proves to be effective and cost-efficient, strategies for its translation into routine care should be developed.

Trial registration

German clinical trials register. DRKS-ID: DRKS00031482.
Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer
Authors: Caricasulo Maria Azzurra , Zanetti Adriana , Terao Mineko , Garattini Enrico , Paroni Gabriela
Published: February 2024

All-trans retinoic acid (ATRA) is the most relevant and functionally active metabolite of Vitamin-A. From a therapeutic standpoint, ATRA is the first example of pharmacological agent exerting its anti-tumor activity via a cell differentiating action. In the clinics, ATRA is used in the treatment of Acute Promyelocytic Leukemia, a rare form of myeloid leukemia with unprecedented therapeutic results. The extraordinary effectiveness of ATRA in the treatment of Acute Promyelocytic Leukemia patients has raised interest in evaluating the potential of this natural retinoid in the treatment of other types of neoplasias, with particular reference to solid tumors.

The present article provides an overview of the available pre-clinical and clinical studies focussing on ATRA as a therapeutic agent in the context of breast cancer from a holistic point of view. In detail, we focus on the direct effects of ATRA in breast cancer cells as well as the underlying molecular mechanisms of action. In addition, we summarize the available information on the action exerted by ATRA on the breast cancer micro-environment, an emerging determinant of the progression and invasive behaviour of solid tumors. In particular we discuss the recent evidences of ATRA activity on the immune system. Finally, we analyse and discuss the results obtained with the few ATRA-based clinical trials conducted in the context of breast cancer.

Graphical Abstract
Recognizing the role of Epstein-Barr virus in gastric cancer: transcriptomic insights into malignancy modulation
Authors: Anbouhi Tabassom Sedaghat , Sazegar Hossein , Rahimi Ebrahim
Published: February 2024

Background

Studies show that Epstein-Barr virus (EBV) infection can play a role in malignancy and increase the risk of gastric cancer (GC). The objective of this research was to pinpoint genes whose expression may be influenced by EBV and play a role in the development of GC.

Methods

Candidate genes potentially susceptible to expression modulation in the presence of EBV were identified through the analysis of GSE185627 and GSE51575 datasets. The association of candidate genes with GC and the survival rate of patients was investigated based on the cancer genome atlas (TCGA) data. Also, pathways related to candidate genes were examined through the MsigDB database. The PPI network was used to identify Hub genes. To corroborate the obtained results, we utilized the RT-qPCR method, employing GC samples from both EBV + and EBV-cases, as well as adjacent normal samples.

Results

Our results showed that genes upregulated by the EBV in the GC cell line, as well as in EBV + samples, are significantly linked to pathways involving the immune response, inflammation, and the P53 pathway. Conversely, genes downregulated by EBV are closely linked to pathways involving cell proliferation and mTORC1. Examining the candidate genes revealed that a considerable portion of genes susceptible to downregulation under the influence of EBV exhibit oncogenic roles based on TCGA data. Moreover, some of these genes are associated with an unfavorable prognosis. Protein-protein interaction network analysis of candidate genes highlighted IFI44L and OAS2 as potential hub genes in the EBV-GC axis. Our RT-qPCR results further validated these findings, demonstrating that the expression levels of IFI44L and OAS2 were higher in EBV + samples compared to both healthy and EBV-samples.

Conclusion

Our study underscores the capacity of EBV to exert regulatory control over genes associated with GC malignancy. In addition to its inflammatory effects, EBV elicits transcriptomic changes that appear to attenuate the progression of GC.
Cerebrospinal fluid shunt surgery reduces the risk of developing dementia and Alzheimer’s disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-weighted cohort study
Authors: Tseng Pao-Hui , Huang Wan-Ting , Wang Jen-Hung , Huang Bor-Ren , Huang Hsin-Yi , Tsai Sheng-Tzung
Published: February 2024

Background

Patients with idiopathic normal-pressure hydrocephalus (iNPH) are predisposed to developing dementing disorders. Cerebrospinal fluid (CSF) shunt implantation is a treatment used to improve the motor and cognitive disabilities of these patients; however, its effect on the risk of developing dementing disorders remains unclear. We conducted a population-based propensity-weighted cohort study to investigate whether CSF shunt surgery may reduce the risk of subsequently developing dementia, Alzheimer’s disease (AD), and vascular dementia in iNPH patients.

Methods

Patients aged ≥ 60 years who were diagnosed with iNPH (n = 2053) between January 2001 and June 2018 were identified from the Taiwan National Health Insurance Research Database. Various demographic characteristics (age, sex, and monthly income) and clinical data (incidence year, comorbidities, and Charlson comorbidity index) were collected and divided into the shunt surgery group (SSG) and the non-shunt surgery group (NSSG). Stabilized inverse probability of treatment weighting by using the propensity score was performed to achieve a balanced distribution of confounders across the two study groups. The cumulative incidence rate and risk of dementing disorders were estimated during a 16-year follow-up period.

Results

After weighting, the data of 375.0 patients in SSG and 1677.4 patients in NSSG were analyzed. Kaplan–Meier curve analysis indicated that the cumulative incidence rate of AD (p = 0.009), but not dementia (p = 0.241) and vascular dementia (p = 0.761), in SSG was significantly lower than that in NSSG over the 16-year follow-up period. Cox proportional hazards regression analysis revealed that SSG had a reduced hazard ratio (HR) for developing AD [HR (95% CI) 0.17 (0.04–0.69)], but not for dementia [HR (95% CI) 0.83 (0.61–1.12)] and vascular dementia [HR (95% CI) 1.18 (0.44–3.16)], compared with NSSG. Further Fine–Gray hazard regression analysis with death as a competing event demonstrated that SSG had a reduced subdistribution HR (sHR) for developing dementia [sHR (95% CI) 0.74 (0.55–0.99)] and AD [sHR (95% CI) 0.15 (0.04–0.61)], but not for vascular dementia [sHR (95% CI) 1.07 (0.40–2.86)].

Conclusion

CSF shunt surgery is associated with reduced risks of the subsequent development of dementia and AD in iNPH patients. Our findings may provide valuable information for assessing the benefit-to-risk profile of CSF shunt surgery.
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Authors: Jäntti Henna , Jonk Steffi , Gómez Budia Mireia , Ohtonen Sohvi , Fagerlund Ilkka , Fazaludeen Mohammad Feroze , Aakko-Saksa Päivi , Pebay Alice , Lehtonen Šárka , Koistinaho Jari , Kanninen Katja M. , Jalava Pasi I. , Malm Tarja , Korhonen Paula
Published: February 2024

Background

Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer’s disease. Inhaled components of PM may directly invade the brain via the olfactory route, or act through peripheral system responses resulting in inflammation and oxidative stress in the brain. Microglia are the immune cells of the brain implicated in the progression of neurodegenerative diseases. However, it remains unknown how PM affects live human microglia.

Results

Here we show that two different PMs derived from exhausts of cars running on EN590 diesel or compressed natural gas (CNG) alter the function of human microglia-like cells in vitro. We exposed human induced pluripotent stem cell (iPSC)-derived microglia-like cells (iMGLs) to traffic related PMs and explored their functional responses. Lower concentrations of PMs ranging between 10 and 100 µg ml−1 increased microglial survival whereas higher concentrations became toxic over time. Both tested pollutants impaired microglial phagocytosis and increased secretion of a few proinflammatory cytokines with distinct patterns, compared to lipopolysaccharide induced responses. iMGLs showed pollutant dependent responses to production of reactive oxygen species (ROS) with CNG inducing and EN590 reducing ROS production.

Conclusions

Our study indicates that traffic-related air pollutants alter the function of human microglia and warrant further studies to determine whether these changes contribute to adverse effects in the brain and on cognition over time. This study demonstrates human iPSC-microglia as a valuable tool to study functional microglial responses to environmental agents.
The mechanisms of milder clinical symptoms of COVID-19 in children compared to adults
Authors: Luo Caiyin , Chen Wanwen , Cai Junying , He Yuwen
Published: February 2024

In stark contrast to adult patients, children who contract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) typically manifest milder symptoms or remain asymptomatic. However, the precise underlying mechanisms of this pathogenesis remain elusive. In this review, we primarily retrospect the clinical characteristics of SARS-CoV-2 infection in children, and explore the factors that may contribute to the typically milder clinical presentation in pediatric Coronavirus Disease 2019 (COVID-19) patients compare with adults patients with COVID-19. The pathophysiological mechanisms that mitigate lung injury in children are as follows: the expression level of ACE2 receptor in children is lower; the binding affinity between ACE2 receptors and viral spike proteins in children was weaker; children have strong pre-activated innate immune response and appropriate adaptive immune response; children have more natural lymphocytes; children with COVID-19 can produce higher levels of IgM, IgG and interferon; children infected with SARS-CoV-2 can produce lower levels of IL-6 and IL-10; children have fewer underlying diseases and the lower risk of worsening COVID-19; children are usually exposed to other respiratory viruses and have an enhanced cross-reactive immunity. Comprehending the relative contributions of these processes to the protective phenotype in the developing lungs can help in the diagnosis, treatment and research pertaining to children with COVID-19.
Synthesis and characterization of Cu-Doped ZnO nanostructures for UV sensing application
Authors: Al-heuseen K. , Aljameel A. I. , Hussein R. K.
Published: February 2024

In this work, Fabrication, and characterization of Cu-doped ZnO thin films deposited on porous silicon (PSi) substrates have been reported using electrochemical deposition (ECD) technique. The influence of Cu-doping concentrations on morphology, structure, and electrical characteristics of zinc oxide (ZnO) thin films were presented. X-ray diffraction analysis (XRD) has been used to characterize the lattice constants, average size, in-plane (along a-axis) and out of plane (along c-axis) strains for the Cu–ZnO crystals. The effects of Cu-doping concentration on crystal parameters were also investigated from the XRD analysis. The samples were used for UV-sensing applications. In addition, Cu-doped ZnO and pure ZnO metal–semiconductor-metal photodetector, with Cu as electrode contacts were successfully produced for ultraviolet (UV) detection. TheI-V(current–voltage) characteristics were used to study the sensing enhancement. Finally, the UV photodetector based on Cu-doped ZnO films was successfully fabricated and shows a five times enhancement in the sensitivity to UV light compared to that of pure ZnO photodetector.
Iron oxide nanoparticles coated with Glucose and conjugated with Safranal (Fe3O4@Glu-Safranal NPs) inducing apoptosis in liver cancer cell line (HepG2)
Authors: Mikaeili Ghezeljeh Somayeh , Salehzadeh Ali , Ataei-e Jaliseh Somayeh
Published: February 2024

Magnetic nanoparticles can be considered a reliable tool for targeted drug delivery to cancer tissues. Based on this, in this study, the anticancer effect of iron oxide nanoparticles coated with glucose and conjugated with Safranal (Fe3O4@Glu-Safranal NPs) on a liver cancer cell line (HepG2) was investigated. Physicochemical properties of nanoparticles were characterized using FT-IR, XRD, VSM, EDS-mapping, SEM and TEM imaging, zeta potential, and DLS analyses. MTT test was used to investigate the inhibitory effect of nanoparticles on cancer and normal cell lines. Also, the reactive oxygen species (ROS) level, the population of apoptotic cells, and cell cycle analysis were evaluated in control and nanoparticle-treated cells. The synthesized particles were spherical, in a size range of 17–49 nm, without impurities, with a surface charge of − 13 mV and hydrodynamic size of 129 nm, and with magnetic saturation of 22.5 emu/g. The 50% inhibitory concentration (IC50) of Safranal, Fe3O4, Fe3O4@Glu-Safranal and Cisplatin drug on liver cancer cells were 474, 1546, 305 and 135 µg/mL, respectively. While, the IC50 of Fe3O4@Glu-Safranal for normal cell line was 680 µg/mL. Treating liver cancer cells with nanoparticles significantly increased the population of apoptotic cells from 2.5% to 34.7%. Furthermore, the population of the cells arrested at the G2/M phase increased in nanoparticle-treated cells. Due to the biocompatibility of the constituent compounds of these nanoparticles, their magnetic properties, and their inhibitory effects on cancer cells, Fe3O4@Glu-Safranal NPs can be further considered as a promising anticancer compound.
Investigation on storage level data integrity strategies in cloud computing: classification, security obstructions, challenges and vulnerability
Authors: Goswami Paromita , Faujdar Neetu , Debnath Somen , Khan Ajoy Kumar , Singh Ghanshyam
Published: February 2024

Cloud computing provides outsourcing of computing services at a lower cost, making it a popular choice for many businesses. In recent years, cloud data storage has gained significant success, thanks to its advantages in maintenance, performance, support, cost, and reliability compared to traditional storage methods. However, despite the benefits of disaster recovery, scalability, and resource backup, some organizations still prefer traditional data storage over cloud storage due to concerns about data correctness and security. Data integrity is a critical issue in cloud computing, as data owners need to rely on third-party cloud storage providers to handle their data. To address this, researchers have been developing new algorithms for data integrity strategies in cloud storage to enhance security and ensure the accuracy of outsourced data. This article aims to highlight the security issues and possible attacks on cloud storage, as well as discussing the phases, characteristics, and classification of data integrity strategies. A comparative analysis of these strategies in the context of cloud storage is also presented. Furthermore, the overhead parameters of auditing system models in cloud computing are examined, considering the desired design goals. By understanding and addressing these factors, organizations can make informed decisions about their cloud storage solutions, taking into account both security and performance considerations.
On the onset and dispersal of a major MDR TB clone among HIV-negative patients, Tunisia
Authors: Dekhil Naira , Mardassi Helmi
Published: February 2024

Background

To carry out a whole genome sequencing (WGS)-based investigation on the emergence and spread of the largest multidrug-resistant tuberculosis (MDR TB) outbreak that has been thriving among HIV-negative patients, Tunisia, since the early 2000s.

Methods

We performed phylogeographic analyses and molecular dating based on a WGS dataset representing 68 unique Mycobacterium tuberculosis isolates, covering almost the entire MDR TB outbreak for the time period 2001–2016.

Results

The data indicate that the ancestor of the MDR TB outbreak emerged in the region of Bizerte, as early as 1974 (95% CI 1951–1985), from where it spread to other regions by 1992 (95% CI 1980–1996). Analysis of a minimum spanning tree based on core genome Multilocus Sequence Typing (cgMLST) uncovered the early spill-over of the fitness-compensated MDR TB strain from the prison into the general population. Indeed, cases with history of incarceration were found to be directly or indirectly linked to up to 22 new outbreak cases (32.35%) among the non-imprisoned population. By around 2008, the MDR TB outbreak strain had acquired additional resistance, leading to an XDR phenotype.

Conclusions

WGS allowed refining our understanding of the emergence and evolution of the largest MDR TB outbreak in Tunisia, whose causative strain has been circulating silently for almost 26 years before. Our study lends further support to the critical role of prisons-related cases in the early spread of the outbreak among the general population. The shift to an XDR phenotype of such an epidemic clone prompts an urgent need to undertake drastic control measures.
Pragmatic competence in people with dual diagnosis: down syndrome and autism spectrum disorder
Authors: Escudero Sara Cortés , Sepúlveda Esther Moraleda
Published: February 2024

Background

Pragmatics is an area that can be affected in a wide variety of disorders. In this sense, Syndromic Autism is defined as a disorder in which a causal link is established between an associated syndrome and Autism Spectrum Disorder (ASD). Likewise, Down Syndrome (DS) is one of the main genetically based syndromes in which ASD is described as one of its possible manifestations. In this direction, people with DS are described as social beings whereas in ASD there seems to be a specific alteration of this domain.

Methods

In this study, pragmatic performance was analysed in a sample of 72 participants, where comparisons were made between the scores obtained by children with ASD (n = 24), with DS (n = 24) and with DS + ASD (n = 24).

Results

The Social Communication Questionnaire (SCQ), the Block Objective and Criterial Language Battery (BLOC-SR) and the Neuropsychology subtest (NEPSY-II) aimed at Theory of Mind (ToM) identified significant differences between the groups. However, two-to-two comparisons reported no significant differences between DS and DS + ASD.

Conclusions

Although several studies report differences between the three proposed groups, our data seem to suggest that ASD symptomatology in DS is associated with Intellectual Developmental Disorder (IDD). However, the lack of solid scientific evidence regarding comorbid diagnosis makes further research along these lines indispensable.

Trial registration

This study was approved by the Ethics Committee for Social Research at UCLM with reference CEIS-704,511-L8M4.
Allometric scaling for left ventricular mass and geometry in male and female athletes of mixed and endurance sports
Authors: Oxborough David , McDerment Danielle , George Keith P. , Johnson Christopher , Morrison Barbara , Parry-Williams Gemma , Papatheodorou Efstathios , Sharma Sanjay , Cooper Robert
Published: February 2024

Background

The athlete’s heart (AH) defines the phenotypical changes that occur in response to chronic exercise training. Echocardiographic assessment of the AH is used to calculate LV mass (LVM) and determine chamber geometry. This is, however, interpreted using standard linear (ratiometric) scaling to body surface area (BSA) whereas allometric scaling is now widely recommended. This study (1) determined whether ratiometric scaling of LVM to BSA (LVMiratio) provides a size-independent index in young and veteran athletes of mixed and endurance sports (MES), and (2) calculated size-independent beta exponents for allometrically derived (LVMiallo) to BSA and (3) describes the physiological range of LVMiallo and the classifications of LV geometry.

Methods

1373 MES athletes consisting of young (< 35 years old) (males n = 699 and females n = 127) and veteran (> 35 years old) (males n = 327 and females n = 220) were included in the study. LVMiratio was calculated as per standard scaling and sex-specific LVMiallo were derived from the population. Cut-offs were defined and geometry was classified according to the new exponents and relative wall thickness.

Results

LVMiratio did not produce a size independent index. When tested across the age range the following indexes LVMi/BSA0.7663 and LVMi/BSA0.52, for males and females respectively, were size independent (r = 0.012; P = 0.7 and r = 0.003; P = 0.920). Physiological cut-offs for LVMiallo were 135 g/(m2)0.7663 in male athletes and 121 g/(m2)0.52 in female athletes. Concentric remodelling / hypertrophy was present in 3% and 0% of young male and female athletes and 24% and 17% of veteran male and female athletes, respectively. Eccentric hypertrophy was observed in 8% and 6% of young male and female athletes and 9% and 11% of veteran male and female athletes, respectively.

Conclusion

In a large cohort of young and veteran male and female MES athletes, LVMiratio to BSA is not size independent. Sex-specific LVMiallo to BSA with LVMi/BSA0.77 and LVMi/BSA0.52 for male and female athletes respectively can be applied across the age-range. Population-based cut-offs of LVMiallo provided a physiological range demonstrating a predominance for normal geometry in all athlete groups with a greater percentage of concentric remodelling/hypertrophy occurring in veteran male and female athletes.
Increase in physical activity is associated with an increase in sleep efficiency, but not with improvement in symptoms of PTSD: analysis of longitudinal data in trauma-affected refugees
Authors: Sandahl Hinuga , Korshøj Mette , Mortensen Ole Steen , Carlsson Jessica
Published: February 2024

Background

In trauma-affected refugees with posttraumatic stress disorder (PTSD), research on physical activity is scarce. Knowing more about the relation between physical activity and PTSD symptoms may provide insight into physical activity as a possible target in the treatment of PTSD. The aim of the present study was to examine whether baseline and change in level of physical activity from baseline to end of treatment were related to, respectively, baseline and change in PTSD symptoms, quality of life, sleep quality, and sleep efficiency in trauma-affected refugees.

Methods

Longitudinal data from a randomized controlled trial were analysed with multiple linear regression. Level of physical activity and sleep efficiency were measured with actigraphy and symptoms of PTSD, sleep quality, and quality of life were measured with self-report questionnaires.

Results

A higher level of physical activity was significantly associated with better baseline sleep quality, borderline associated with quality of life, but not with symptoms of PTSD, or sleep efficiency. Furthermore, an increase in level of physical activity was significantly associated with improvement in sleep efficiency. Change in level of physical activity was not significantly associated with improvement in PTSD symptoms, quality of life, or sleep quality.

Conclusion

The novelty of the current study lies in the finding of no relation between a change in level of physical activity and a change in symptoms of PTSD. The results point to a complex relation between sleep, physical activity and PTSD and point towards a need for studies on these relations to provide effective interventions in trauma-affected refugees.

Trial registration

ClinicalTrials.gov ID (NCT02761161), April 27, 2016.
Reducing the Environmental Impact of Health Care Conferences: A Study of Emissions and Practical Solutions
Authors: Lichter Katie E. , Sabbagh Ali , Demeulenaere Sasha , Drew Taylor , Conway Alexandra , Nogueira Leticia , Suneja Gita , Kirkwood Kelsey , Hampshire Karly , Gundling Katherine , Teherani Arianne , Thottathil Sapna E. , Mohamad Osama
Published: February 2024

PURPOSE

We aimed to examine the impact of different conference formats (in-person, virtual, and hybrid) of the ASCO conference on greenhouse gas (GHG) emissions and to recommend sustainable options for future conferences.

MATERIALS AND METHODS

This study used data on the number of attendees, their departure locations, and the type of attendance (in-person v virtual) provided by ASCO between 2019 and 2022. The GHG emissions resulting from air and ground travel, remote connectivity, conference space utilization, hotel stays, distributed conference materials, and electricity use were estimated for each year. Emissions were stratified by attendee country of origin, type of attendance, and year. Simulations were conducted to evaluate how changes in conference size, location, and format impact emissions, as well as estimate the resulting mitigations from adopting the proposed changes.

RESULTS

The highest estimated GHG emissions, calculated in carbon dioxide equivalents (CO2e), were associated with the 2019 in-person conference (37,251 metric tons of CO2e). Although international attendees had the largest contribution to emissions in all years (>50%), location optimization models, which selected conference locations that most minimized GHG emissions, yielded only minimal reductions (approximately 3%). Simulations examining changes to the conference format, location, and attendance percentage suggested that hub-and-spoke, where multiple conference locations are selected by global region, or hybrid models, with both in-person and virtual components, are likely to cause the largest drops in emissions (up to 86%).

CONCLUSION

Using historical conference data, this study identifies key aspects that can be modified to reduce emissions and consequently promote more sustainable and equitable conference attendance. Hybrid conferences may be the best solution to maintain the networking opportunities provided by conferences while balancing out their environmental footprint.
Role of Patient Characteristics and Insurance Type in Newly Diagnosed Multiple Myeloma Care Disparities
Authors: Gasoyan Hamlet , Anwer Faiz , Casacchia Nicholas J. , Kovach Jeffrey D. , Valent Jason , Wang Ming , Halpern Michael T. , Rothberg Michael B.
Published: February 2024

PURPOSE

Little is known about the role of social determinants of health (SDOH) in the utilization of novel treatments among patients with newly diagnosed multiple myeloma (NDMM).

METHODS

This retrospective cohort study used Taussig Cancer Center's Myeloma Patient Registry to identify adults with NDMM between January 1, 2017, and December 31, 2021. Electronic health records data captured treatment with (1) triplet or quadruplet regimen and (2) lenalidomide during the first year after NDMM, and (3) stem-cell transplant (SCT) through December 31, 2022. Multivariable logistic regression models examined associations of demographic/clinical characteristics and SDOH with care patterns.

RESULTS

We identified 569 patients with median age at diagnosis of 66 years (IQR, 59-73); 55% were male, 76% White, 23% Black, 1.1% other races, insured by Medicare (51%), private payer (38%), Medicaid (8.3%), and self-pay/other (1.8%). In the multivariable models, self-pay/other payers (adjusted odds ratio [AOR], 0.15 [95% CI, 0.03 to 0.54]) was associated with lower odds of triplet or quadruplet regimen, compared with Medicare. Private insurance (AOR, 0.48 [95% CI, 0.27 to 0.86]) and self-pay/other payers (AOR, 0.16 [95% CI, 0.04 to 0.74]) had lower odds of lenalidomide. Black patients ( v White; AOR, 0.47 [95% CI, 0.26 to 0.85]) and patients treated at regional hospitals ( v Taussig Cancer Center; AOR, 0.27 [95% CI, 0.12 to 0.57]) had lower odds of SCT. The odds of receiving triplet or quadruplet regimen, lenalidomide, and SCT also varied by the year of NDMM.

CONCLUSION

Care for NDMM varied based on race, insurance type, year of diagnosis, and treatment facility. It may be useful to examine the impact of insurance-related characteristics and recent policy initiatives on care disparities.
Accessing the Divine: Indigenous Medical Specialists, Catholic Priests, and Nonorthodox Methods of Healing in Colonial Mexico
Authors: Hagler Anderson
Published: February 2024

This study examines forty-six colonial records spanning over two centuries (ca. 1581–1802), the majority of which consist of Mexican Inquisition and criminal trials. The article illuminates how Indigenous medical specialists, alternatively labeled ritual specialists, maintained communal solidarity by accessing the divine using sacred rituals. From New Spain’s southern extremity in Chiapas to its northern frontier in Santa Fe, devout commoners made votive offerings to combat disease and recalibrate the cosmos. Indigenous medical specialists such as curanderos and midwives remained influential locally because commoners perceived their ceremonies to be efficacious. Ritual specialists used their advanced knowledge of medicine and spirituality to alleviate illnesses like dysentery, fever, and typhoid. Concern for ailing family members prompted Natives to take an inclusive approach to the treatment of disease, which could conflict with church doctrine. Case testimony reveals that diverse, nonorthodox methods of healing persisted in the face of Spanish colonization. Faith in the efficacy of Indigenous cosmologies helped the infirm to envisage a better life, instilling hope. The study’s focus on the spiritual and material illuminates how ancestral knowledge produced political and social ramifications centuries after inception, demonstrating how the past reverberates into the present.
Stem cell modeling of nervous system tumors
Authors: Furnari Frank B. , Anastasaki Corina , Bian Shan , Fine Howard A. , Koga Tomoyuki , Le Lu Q. , Rodriguez Fausto J. , Gutmann David H.
Published: February 2024

Nervous system tumors, particularly brain tumors, represent the most common tumors in children and one of the most lethal tumors in adults. Despite decades of research, there are few effective therapies for these cancers. Although human nervous system tumor cells and genetically engineered mouse models have served as excellent platforms for drug discovery and preclinical testing, they have limitations with respect to accurately recapitulating important aspects of the pathobiology of spontaneously arising human tumors. For this reason, attention has turned to the deployment of human stem cell engineering involving human embryonic or induced pluripotent stem cells, in which genetic alterations associated with nervous system cancers can be introduced. These stem cells can be used to create self-assembling three-dimensional cerebral organoids that preserve key features of the developing human brain. Moreover, stem cell-engineered lines are amenable to xenotransplantation into mice as a platform to investigate the tumor cell of origin, discover cancer evolutionary trajectories and identify therapeutic vulnerabilities. In this article, we review the current state of human stem cell models of nervous system tumors, discuss their advantages and disadvantages, and provide consensus recommendations for future research.
Comprehensive overview of the role of mitochondrial dysfunction in the pathogenesis of acute kidney ischemia-reperfusion injury: a narrative review
Authors: Kim Min-Ji , Oh Chang Joo , Hong Chang-Won , Jeon Jae-Han
Published: February 2024

Acute kidney ischemia-reperfusion (IR) injury is a life-threatening condition that predisposes individuals to chronic kidney disease. Since the kidney is one of the most energy-demanding organs in the human body and mitochondria are the powerhouse of cells, mitochondrial dysfunction plays a central role in the pathogenesis of IR-induced acute kidney injury. Mitochondrial dysfunction causes a reduction in adenosine triphosphate production, loss of mitochondrial dynamics (represented by persistent fragmentation), and impaired mitophagy. Furthermore, the pathological accumulation of succinate resulting from fumarate reduction under oxygen deprivation (ischemia) in the reverse flux of the Krebs cycle can eventually lead to a burst of reactive oxygen species driven by reverse electron transfer during the reperfusion phase. Accumulating evidence indicates that improving mitochondrial function, biogenesis, and dynamics, and normalizing metabolic reprogramming within the mitochondria have the potential to preserve kidney function during IR injury and prevent progression to chronic kidney disease. In this review, we summarize recent advances in understanding the detrimental role of metabolic reprogramming and mitochondrial dysfunction in IR injury and explore potential therapeutic strategies for treating kidney IR injury.
THE LEGAL BASIS OF THE STATE ANTI-CORRUPTION POLICY IN THE FIELD OF EDUCATION
Authors: Gusengadzhiev Rasul A.
Published: February 2024

Relevance. Studies in different regions of the Russian Federation confirm that corruption affects all spheres of society. The education system has not been left out. This negative phenomenon is also characteristic of this department, which, in turn, should become a standard of honesty and fairness, given its main activity – education and socialization of the younger generation. Therefore, corruption in the field of education has irreparable omissions and serious consequences.

Anticipating these consequences, an anti-corruption policy is being implemented at the state level aimed at forming a personality with sustainable anti-corruption behavior. This policy is based on a legal system with a long history. The paper analyzes the regulatory and legal aspects related to anti-corruption policy. The preventive activity of subjects of prevention of corruption offenses is summarized.

Purpose and methods. The purpose of the study is to analyze the effectiveness of regulatory legal acts related to anti-corruption policy in the field of education. To achieve this goal, the research uses the comparative legal method, generalization and analysis of normative legal acts, the method of expert assessments, content analysis, and sociological methods.

Results. The state anti-corruption policy aimed at forming a personality with sustainable anti-corruption behavior is of paramount importance in the system of countering a dangerous phenomenon. In contrast to forceful methods, anti-corruption policy, which has a strong legal basis, conducted at the state level, has good prospects. Intolerance to corrupt behavior is formed among young people from school, and anti-corruption “immunity” is developed.

Practical implications.  The results of the study can be used in the preparation of regional anti-corruption programs in the field of education.
The role of polyphenols in the prevention and treatment of cancer
Authors: Szypuła Aleksandra , Michalik Beniamin , Galasińska Iwona , Hajduk-Maślak Katarzyna , Skóra Adrianna , Sęk Michał
Published: February 2024

Introduction: Polyphenolic compounds are widespread in nature, contained in large quantities especially in fruits, vegetables, cereals and nuts. In recent years numerous attempts have been made to characterize their biological effects, with particular emphasis on their protective potential against the development of chronic diseases, including cancer.

Purpose of the study: The aim of the study was to collect and analyze publications on the use of polyphenols in the prevention and treatment of cancer, with particular emphasis on breast cancer, colon cancer, prostate cancer and lung cancer - the four most common cancers in the Polish population.

Material and methods: A review of the literature available on PubMed was performed using various combinations of keywords: 'polyphenols' + 'cancer', 'polyphenols' + 'oncology', ‘polyphenols’ + ‘chemoprevention’, ‘polyphenols’ + ‘chemotherapy’, 'polyphenols' + 'lung cancer', 'polyphenols' + 'breast cancer', ‘polyphenols’ + ‘colorectal cancer’, 'polyphenols' + 'prostate cancer'/'prostate gland cancer'.

Results: The analysis of the collected publications allows to conclude that polyphenols exert multidirectional anticancer effect through antioxidant, antiproliferative, anti-inflammatory, immunomodulatory and prosenescence activity. This effect has been demonstrated, among others, in relation to cellular models of colorectal cancer, prostate cancer, breast cancer, cervical cancer and lung cancer. Polyphenols also reduce side effects associated with the use of conventional anticancer therapies and increase their effectiveness.

Conclusions: Polyphenols - both as independent compounds and components of complex anticancer treatment regimens - have chemopreventive and potentially chemotherapeutic effects. By influencing various stages of carcinogenesis - initiation, promotion and progression of cancer - they constitute a promising direction for the development of new, more effective forms of therapy and prevention of cancer.