bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience in treating patients with diabetes and anastomotic false aneurysm after reconstructive interventions in the aortic-femoral segment
Authors: Nikulnikov P. I. , Liksunov O. V. , Ratushniuk A. V. , Severyn V. L. , Bicher A. G. , Buriak N. A. , Bura I. B.
Published: December 2021

The purpose of the work isto analyze and improve the results of treatment of patients with diabetes and anastomotic false aneurysm (FA) after reconstructive interventions. Materials and methods. The results of diagnostic examinations in 79 patients with 93 false anastomotic aneurysms were analyzed, the criteria of wound complication (hematoma, infiltrate), patency of shunts, bleeding, heart attack, stroke were evaluated. Among the patients there were 75 (94.9 %) men and 4 (5.1 %) women aged 40—75 years (mean age — (58.4 ± 2.9) years). 69 (87.3 %) patients underwent surgery for atherosclerotic lesions of the pelvic vessels and lower extremities, including 43 (54.4 %) patients with diabetes, 3 (3.8 %) — for abdominal aortic aneurysm, 4 (5.1 %) — after vascular injury, 3 (3.8%) — due to nonspecific aortic arteritis. A total of 79 patients underwent 93 reconstructive interventions. Results and discussion. The time of onset of clinical symptoms (pain, pulsation), which give reason to suspect the occurrence of FA, ranged from 8 days to 19 years: in 15 patients — less than 1 year, in 59 — up to 10 years, in 5 — up to 20 years. The average duration of FA formation after surgery is 62.5 months. The absence of pathological changes in the area of the proximal anastomosis and the presence of adequate outflow pathways in most cases allow us to limit the reconstruction of the distal anastomosis. Conclusions. Early diagnosis and surgical tactics for false anastomotic aneurysms in patients with diabetes can prevent complications and improve the results of surgical treatment. The optimal type of surgery for false aneurysms is their removal with re-prosthesis of the affected segment, which allows to save the limb and the patient's life. The use of modern pharmacological agents allows to reduce the progression of atherosclerosis, which is the main cause of false aneurysms. Dynamic ultrasound monitoring is required for patients who have undergone reconstructive vascular surgery.
Glycemic control in children and young adults with different types of diabetes mellitus in Ukraine
Authors: Globa E. V. , Zelinska N. B.
Published: December 2021

Introduction. Until recently, glycated hemoglobin (HbA1c) has not been studied in children with different types of diabetes mellitus (DM). With the development of molecular genetics, new types of diabetes have been diagnosed, including neonatal (ND) and maturity onset diabetes of the young (MODY), which usually require specific pathogenetic therapy, including sulfonylureas (SU), which improve glycemic control in patients with certain mutations.

The aim of this study, which was conducted for the first time in Ukraine, was to analyze glycemic control in patients with different types of DM, including ND and MODY and changing their treatment after genetic testing.

Materials and methods. We studied conducted the analysis of glycemic control in patients depending on the type of diabetes, namely: type 1 diabetes (n = 9282), type 2 diabetes (n = 23), ND (n = 16) with mutations KCNJ11, ABCC8 and MODY (n = 16) with mutations in HNF1A/HNF4A and ABCC8 genes. To confirm the nature of monogenic diabetes, targeting next-generation sequencing (tNGS) of all known neonatal and monogenic diabetes genes was performed.

Results. According to the Register in 2018, in Ukraine the average age of children with type 1 DM was 11.5 ± 1.4 years, and the level of HbA1c was unsatisfactory (8.8 ± 2.01 %). The proportion of children who had ideal or optimal glycemic control (HbA1c
Introduction of the quality of life concept in practical medicine
Authors: Kvitka D. M. , Palamarchuk V. O. , Zemskov S. V. , Sichinava R. M.
Published: December 2021

The modern stage of medical development requires a multidisciplinary approach to studying the impact of treatment on human life. The social aspects are of great importance because the goal of treatment is to preserve or/and improve life. Therefore, the term "quality of life" is increasingly used in the world medical literature. The objectification of this indicator and its adaptation in practical medicine is a priority task. The concept of "quality of life" first appeared in 1958. In the future, this concept was developed in a research carried out by a group of professors at MIT (Massachusetts Institute of Technology) under Prof. R. Bauer in 1966. These researches initiated the quality of life study. In 1996, the WHO developed a definition of quality of life as an individual’s perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. The purpose of studying the quality of life in the medical field was to introduce treatment protocols and standardize medical care. An important criterion for evaluating the quality of treatment was to compare changes in the patient’s quality of life before and after using a particular medical protocol. The main methods of studying changes in the patient’s quality of life were the use of special questionnaires. The most common general-purpose questionnaires for assessing changes in quality of life are SF-36, WHOQoL-100, Sickness Impact Profile, Nottingham Health Profile, EuroQoL-5D, EORTC QLQ-C30. In Ukraine, as of 2020, there is no local questionnaire for either general or specialized purposes. But there are translations of the main questionnaires, for example, SF-36, EORTC QLQ-C30. Developing own questionnaire that fully complies with the standards of the MAPI Research Institute requires multi-center and multidisciplinary research. The study of changes in the quality of life is an integral part of a comprehensive analysis of new methods of the diagnosis, treatment and prevention of diseases. Analysis of changes in the quality of life using different approaches to treatment is possible provided that general and special purpose questionnaires and available clinical data are used. Using advanced statistical processing of the questionnaire survey allows you to increase the reliability of the research. There is a need to develop own specialized adapted nosological questionnaires for quality of life analysis. Assessment of the quality of life should become one of the main criteria for the effectiveness of medical care, as well as an independent indicator of the condition of patients during medical and social expertise, determining the prognosis, treatment tactics, and developing rehabilitation programs.
Integrated analysis of gene expression of solute carrier gene SLC19A3 with proven risk factors of microvascular complications in patients with type 2 diabetes
Authors: Singh K. , Yuzvenko T. Yu.
Published: December 2021

Diabetes mellitus (DM) is a chronic progressive disorder which leads to significant disability, morbidity and is likely to progress to become one of the most widespread conditions worldwide and as an additional burden to the healthcare system already reeling under the effects of the COVID-19 pandemic worldwide.

Aim — to study the correlative variation in gene expression of SLC19A3 in type 2 diabetes patients with proven risk factors of diabetes complications.

Materials and methods. In the study, 190 patients with type 2 DM were screened for diabetic peripheral neuropathy (DPN). DPN was confirmed in (n = 105) patients displaying symptoms of diabetic polyneuropathy with the involvement of small nerve fibers and large nerve fibers. Out of the total cohort, 45 patients with type 2 DM were shortlisted and randomized according to the severity of diabetic polyneuropathy, for assessment of the expression of the gene SLC19A3 in stage 1 of the gene expression study.
Results. In the first stage of the study in patients with type 2 diabetes with diabetic polyneuropathy with the involvement of small nerve fibers and large nerve fibers we found that the difference in expression of the solute carrier gene SLC19A3 in patients with variable levels of neuropathy was not significant. As evident from the CT values and the value of ΔCT there was no statistically valid difference between the groups. The CT value of the target gene (SLC19A3) in all the three groups, in comparison to each other did not have significant difference in the initial phase of the investigation. In correlation to duration of disease the trend was similar, showing that duration of disease does not play an altering role in the expression of the target gene. In correlation to risk factor glycemic control (level of HbA1c) the expression of the target gene was slightly more profound in patients with an HbA1c of < 8.9 % as compared to the patients with HbA1c value > 9.0 %.

Conclusions. Taking into consideration the results of the study it can be stated the expression of SLC19A3 is independent of the severity of diabetic polyneuropathy, duration of diabetes and the glycemic compensation in patients with type 2 diabetes.
Gallbladder influence on carbohydrate metabolism in patients with ischemic heart disease and first-detected hyperglycemia
Authors: Korolyuk O. Ya. , Strilchuk L. M.
Published: December 2021

Aim — to determine the changes in carbohydrate metabolism in case of intact gallbladder(GB) and its disorders including the condition after cholecystectomy in patients with coronary heart disease (CHD).

Materials and methods. Examinations involved 71 inpatients (52.11 % males, 47.89 % females, median age 65 years) with various forms of CHD (acute coronary syndrome, acute myocardial infarction, postinfarction cardiosclerosis), who were treated in cardiological and infarctional wards. All patients were divided into groups depending on the sonographically determined GB status: the 1st group (n = 30) with intact GB, 2ndgroup (n = 24) with inflections, sludge or signs of chronic cholecystitis, the 3rd group (n = 7) withcholelithiasis and calculous cholecystitis, the 4th(n = 10) with the history of cholecystectomy. Thegroupswereage- and no­sology-matching. Apart from routine investigations, 20 parameters of glucose metabolism were determined: oral glucosetolerance test (OGTT) with the estimation of glucose, insulin and C-peptide levels at baseline (0’) and on 30, 60 and 120 minutes after taking of 75 g of glucose; glycated hemoglobin(НbА1c) levels; increasing areas under curves in the early and late phases for glucose (iAUCG 0-30’, 30-120’) and insulin (iAUCI 0-30’, 30-120’); seevral indexes (HOMA-IR, Quicki, Matsuda, Shuster, DeFronzo).

Results. It has been established that GB disorders were accompanied by the significantly less frequent normal glucose metabolism (6.4 % vs 26.7 %) and higher diabetes incidence (19.4 % vs 3.3 %, both p < 0.05) compared to the intact GB. GB condition did not affect the liver insulin sensitivity, the peripheral tissues’ insulin sensitivity, liver clearance of insulin, C-peptide level, as well as the early or late insulin secretion phase, although it was significantly associated with glycemia levels, glycated hemoglobin and the ratio between insulin secretion and the tissue sensitivity. The worst condition of carbohydrate metabolism was observed in case of sludge, GB deformations and signs of chronic cholecystitis: these changes were accompanied by significantly higher glycemia at all points (0’, 30’, 60’, 120’), bigger area under curve for glucose in the late phase (30—120’), higher glycated hemoglobin and lower DeFronzo index. The condition after cholecystectomy was associated with a lower level of glycated hemoglobin, although during the first hour after glucose loading levels of glycemia exceeded the values of people with intact GB.

Conclusion. The gallbladder condition affects carbohydrate metabolism, and its pathological changes are associated with a deterioration of carbohydrate balance.
Influence of androgen deficiency on the endometrium structure in women of reproductive age
Authors: Demyanenko L. V. , Semenyuk L. M. , Yuzvenko T. Yu.
Published: December 2021

Aim — to identify the relationship between androgen deficiency and the development of endometrial hypoplasia in women of reproductive age, to develop an algorithm for the diagnosis and treatment of this category of women.

Materials and methods. Examination of patients with androgen deficiency revealed 48 patients with endometrial hypoplasia based on the ultrasound markers. After examination for CD138 and detection of chronic endometritis during the study, 9 patients were excluded. At the second stage, an immunohistochemical examination was performed for the expression of receptors for estrogen, progesterone and androgens. According to the results, the patients were divided into 2 groups: the first group (24 patients) with a high level of expression of androgen receptors and the second group (15 patients) with a low level of expression of androgen receptors. Theexpressionof receptors to estrogens and progesterone was on medium level and comparative in both groups. Both groups of patients underwent hormonal therapy for 3 months: estradiol valerate 1 g per day in a continuous mode and 200 mg of micronized progesterone from the sixteenth to twenty-fifth days of the menstrual cycle. Additionally, patients of the first group received dehydro­epian­drosterone(DHEA)in a dose of 25 mg per day continuously in the form sublingual spray.

Results. According to the data of ultrasound examination in the first group of patients, the endometrium corresponded to normal parameters both during treatment and 1 and 3 months after stopping treatment. At the same time, in the second group of patients, there was an improvement in the thickness (more than 7 mm) and structure of the endometrium during treatment and the absence of these effects after the termination of hormonal therapy. Considering the recommendations of the Association of Endocrinologists on the superiority of non-tablet forms of androgen preparations in the treatment of androgen deficiency and having a positive and long-term effect when taking sublingual DHEA, it is possible to recommend adding the above form of DHEA to systemic therapy of endometrial hypoplasia against the background of androgen deficiency.

Conclusions. Women with androgen deficiency are more likely to have concomitant endometrial hypoplasia. Immunohistochemical examination of the endometrium of women of reproductive age with androgen deficiency in 24 patients (61.5 %) revealed a high level of expression of androgen receptors. The effectiveness of therapy for endometrial hypoplasia in women with androgen deficiency with addition of androgens to the standard regimens is more effective and has a long-lasting effect. The combination of estrogen-gestagenic therapy and androgens has a positive effect on the gestational potential of the endometrium in women of reproductive age with androgen deficiency.
Two-stage fixation in the treatment of diabetic arthropathy of the ankle
Authors: Rushai A. K. , Skiba V. V. , Lisaychuk Yu. L. , Kovalchuk V. S. , Khomut Yu. V , Jagdal A. A.
Published: December 2021

Aim — to improve the results of treatment of diabetic anklearthropathies by using the final method of fixation by semi-rigid systems after arthrodesis and the use of extrafocal ring fixators (RF).

Materials and methods. The authors presented own experience of treatment of 12 patients with diabeticankle osteoarthropathy. After arthrodesis and fixation with RF, the alternating osteosynthesis was performed with Scotchcast/Softcast bandages.

The use of extrafocal RF of the needle-rod type in the first stage with low trauma wasadvantageous, however the time of fixation before the appearance of the fusion between the tibia and talus was significant, which led to a decrease in the rigidity of the fixation of the bone-needle system and development of inflammation at the exit of the spokes. This required the transition to other means of fixation, which would provide the possibility of functional use of the limb. The authors used Scotchcast/Softcast functional bandages, applied circularly, with stiffeners on the lateral surfaces, which allowed to carry out the supporting function of the limb.

Interventions (arthrodesis of the ankle joint) were performed under multimodal analgesia. Vascular disorders required hematopoietic therapy (use of a tourniquet and administration of tranexamic acid solution) and bemiparin administrationfor microthrombosisprevention. Treatment of diabetic neuropathy and metabolic disorders was carried out by prescribing vitamin B and C, drugs Ca and vitamin D3, antioxidants.

Results. The dynamics of the most examined indicators of the coagulation — anticoagulation system did not differ significantly (activated partial thromboplastic time, prothrombin time, international normalized ratio, platelet quantity). There was a tendency to shift the indicators to the recommended safe zone and even a significant decrease in the level of soluble fibrin monomer complexes (R2= 0.9494).

Conclusions. The use of Scotchcast/Softcast immobilizing bandages in patients with diabetic arthropathy was safe after arthrodesis and RF fixation.This strategy allowed to restore limb capacity in the early stages of treatment, which improved the social adaptation of patients.
On the history and some characteristics of neuroendocrine tumors of the gastrointestinal tract. Neuroendocrine tumors of the pancreas. Part 2
Authors: Rybakov S. I.
Published: December 2021

The literature review presents the analysis of numerous studies that have formed the basis for creating ideas about the diffuse endocrine system,namely existence of the cellular accumulations and individual cells that produce various hormones and biologically active substances in addition to the main endocrine glands. Several types of endocrine cells with these functionshave been established, in particular, in the organs of the gastrointestinal tract, starting from the esophagus and up to the terminal parts of the large intestine. Most of them are contained in the pancreas, antrum of the stomach, duodenum, the initial part of the intestine, in the liver. Excessive secretory activity of these cells can cause the development of pathological clinical syndromes, characterized by the effects of the corresponding hormones. The tumors or diffuse hyperplasia of the corresponding cellsmay present morphological substrate of such syndromes. The author considers the pancreas as an integral part of the diffuse endocrine system, as specific endocrine functions in it perform numerous accumulations (islets of Langerhans) or individual cells. The review of the numerous neuroendocrine tumors of the gastrointestinal tract examines in detail the characteristics of some of them in historical and clinical aspects, in particular Zollinger—Ellison syndrome as the most common and well-studied tumor. Glucagonoma is also considered as a neuroendocrine tumorderived from α-cells of the pancreas, is a kind of insulinoma antagonist, as it secretes an excess of the hormone glucagon, causing the development of hyperglycemic clinical syndrome in contrast to hypoglycemic, caused by insulin. It is a rare tumor and its consideration after insulinoma can be explained by the antagonistic nature of the action of hormones produced by these tumors. In the group of neuroendocrine tumors of the pancreas, glucagonoma follows the frequency of insulinoma and gastrinoma.
The role of myokines in the development of insulin resistance in children, with type 1 diabetes mellitus
Authors: Pashkova O. Ye. , Chudova N. I. , Litvinenko O. S.
Published: December 2021

The aim — to study the role of myokines in the development of insulin resistance in children with type 1 diabetes mellitus.Materials and methods. Observations involved 68 children with type 1 diabetes mellitus (DM 1), with the mean age 11 to 17 years. Depending on the glycemic controllevel, patients were divided into 3 research groups. The control group consisted of 20 relatively healthy children. Muscle mass, the skeletal muscles index, fat mass and the percentage of fat in the bodywere determined in all patients. The Lovett’s test was used to assess the loss of muscle strength; evaluation of insulin resistance was made based onthe triglyceride­glucose index (TYG). Levels of myostatin, irisin, interleukins ­6 and ­13were measured in blood serum.Results and discussion. It has been established that with deterioration in the level of glycemic controlin DM 1 children, the component redistribution of body composition took place with an increased fat mass proportionand decreased muscle mass. This resulted in the reduced insulin-mediatedabsorption of glucose, that was confirmed by the significant increase in TYG level compared to control group. The analysis of cytokines in the blood serum showed a significant increase in the level of myostatin and interleukin­6 compared with the control group and the tendency to increased levels of the interleukins ­13 and the level of irisin in the blood serum in pediatric patients with DM 1. The increased levels of myostatin in DM 1childrenassociated with an increase in the triglycerides content (r = 0.44, p < 0.05) and raised TYG index (r = 0.33, p < 0.05), testifying theclose correlation between the high myostatin levels and the development of insulin resistance.Conclusions. In children with diabetes mellitus, the reduction of muscle strength and muscle mass take place with a deterioration in the state of glycemic control, accompanying by the development of insulin resistance. The violation of myokines synthesis,along with the chronic hyperglycemia and diabetic myopathy, plays the leading role in the formation of insulin resistance in pediatric patients with DM 1. It is manifested by the increased production of myostatin and interleukin­6 in the absence of activation of irisin and interleukin­13synthesis.
Laurence-Moon-Bardet-Biedl syndrome
Authors: Fishchuk O. O. , Ovcharuk M. V. , Biliaeva K. S. , Gurina N. І. , Ovcharuk M. V. , Fishchuk V. V.
Published: December 2021

Lawrence-Moon-Bardet-Biedl syndrome is a rare autosomal recessive genetic disorder, which may result in a number of multiorgan abnormalities, including impaired brain function, eye diseases, kidney and limbs’ dysfunction. The main symptoms of this syndrome include retinal degeneration, polydactyly, obesity, hypogonadism, congenital kidney abnormalities and mental retardation. However, Lawrence-­Moon­-Barde­-Biedl syndrome may also present with other secondary abnormalities, including ataxia, diabetes insipidus, and dental abnormalities. Clinical changes of the eyes include retinitis pigmentosa, low visual acuity, and vision loss, often due to photoreceptor disorders in the retinal tissue with macular degeneration, leading to night blindness and then, in most cases, can cause complete blindness. In patients with an archetypal manifestation of Lawrence­-Moon­-Barde-­Biedl syndrome, abdominal obesity is common, even if the birth weight is usually normal. In addition, this group of patients has type 2 diabetes mellitus. A distinctive feature of this syndrome is postaxial polydactyly. Hypogonadism, which is a common sign of the disease, as usual can be diagnosed at early age in men in a form of micropenis and testicular hypoplasia).The paper presents clinicalcase of Lawrence­-Moon­-Barde-­Bidle syndrome in a thirteen-year-old boy who referred to endocrinologist with complaints of excessivegain of body weight, memoryloss, visual impairment, difficulties in school, delayedsexual development. Ad ditional investigations enabled to establish the diagnosis of Laurence­-Moon­-Bardet­-Biedl syndrome.
A Methodological Review of Fashion Marketing Studies
Authors: ÖZTAY Hilal
Published: December 2021

In this study, fashion marketing studies were examined in terms of method in line with the paradigms adopted in the social sciences. Firstly, explanations of the concepts were presented in order to make sense of the nature of positivist, post-positivist paradigms and quantitative, qualitative research. Then, theses written in the field of fashion marketing in The Council of Higher Education (CoHE) National Thesis Center were analyzed by content analysis. These analyzes were carried out to show the distribution of theses by years in terms of paradigm. In addition, the data collection tools, data analysis techniques and research patterns utilized in the studies were examined, and the techniques that were widely adopted and started to be adopted were explained. According to the findings, quantitative studies are widely used in fashion marketing studies and it has been observed that the use of qualitative and mixed studies have increased in recent years. In quantitative studies, questionnaires and statistical analyzes are widely used and causal research is often applied. In qualitative studies, different data collection and analysis methods are adopted in accordance with the characteristics and design of the research. It has been concluded that mixed studies are mostly designed by adopting multiple methods in accordance with the purpose.
Yeni Dünya Sistemince Sosyal Medya Pazarlaması: Instagram’dan Organik Ürün Tercihi
Authors: EYİCE BASEV Sinem
Published: December 2021

Mobil internetteki hızlı gelişmelerle birlikte sosyal medya platformlarının mobil uygulamalarını kullanan kişi sayısı gün geçtikçe artmaktadır. En bilinen sosyal medya ürünleri arasında anlık mesajlaşma hizmeti veren Facebook, mikroblog hizmeti veren Twitter ve anlık fotoğraf paylaşma hizmeti veren Instagram örnek olarak gösterilebilir. Yeni dünya sistemi olarak da adlandırılan günümüz dijital çağında kullanıcıların bıraktıkları dijital ayak izleri sosyal medya iletişimlerini, tutumlarını, deneyimlerini ve değerlerini anlamada oldukça önemli araştırma verileridir. Bu bağlamdan yola çıkılarak araştırmanın amacı, yeni dünya sisteminde sosyal medya pazarlamasının platformlarından biri olan Instagram’ın organik ürün tercihi örneği kapsamında ele alınmasına ilişkin katılımcı görüşlerinin incelenmesidir. Araştırmanın amacına yönelik olarak, nitel araştırma yöntemlerinden durum çalışması kullanılmıştır. Araştırmanın çalışma grubu 29 yaş ve üstü gönüllü 18 katılımcıdan oluşmuştur. Araştırmanın çalışma grubunu oluşturan katılımcılarla COVID-19 pandemisi nedeniyle görüşmeler Google Meet üzerinden yapılmıştır. Araştırmanın veri toplama aracı olarak araştırmanın çalışma grubunun demografik özelliklerini belirlemeye yönelik 3 soru ve sosyal medya pazarlamasının platformlarından biri olan Instagram’ın organik ürün tercihlerinin belirlenmesine yönelik 19 yarı yapılandırılmış açık uçlu sorudan oluşan görüşme formu kullanılmıştır. Veriler MAXQDA 2018 Programı ile betimsel analiz tekniği kullanılarak analiz edilmiştir. Araştırma sonuçlarının tüketicilerin en fazla zaman geçirdiği sosyal medya platformlarından biri olan Instagram’ın organik ürün tercihinde sosyal medya pazarlamasında ilgili alanyazına katkı sağlayacağı düşünülmektedir
Idea of the Balkan Federation: past and present
Authors: Iskenderov Petr
Published: December 2021

The article is devoted to the main aspects of the problem of creating of the Balkan Federation. The author pays particular attention to the views of Serbian Social Democrats. The author concludes that the idea mentioned-above is in demand in modern conditions.
RELEVANSI BUDAYA DAN PENDIDIKAN KRISTEN DALAM PEMBENTUKAN KARAKTER ANAK DAN PERAN MANUSIA SECARA BIOLOGIS
Authors: Penina
Published: December 2021

beberapa ide pemikiran terkait dengan perkembangan pendidikan kristen yang mampu membentuk karakter anak, sinkronisasi budaya Toraja dan peranan manusia (laki-laki dan perempuan) dalam pengembangan nilai-nilai kekristenan dimasyarakat. Tujuan dari pembuatan artikel ini yaitu untuk mengetahui peran pendidikan kristen terhadap pembentukan karakter anak, Untuk mengetahui sinkronisasi pendidikan kristen dan budaya masyarakat Toraja sebagai pusat peradaban kristen di Indonesia sehingga memberikan kontribusi bagi perkembangan kekristenan di Indonesia dan untuk mengetahui tendensi laki-laki dan perempuan terhadap perkembangan pendidikan kristen di masyarakat.
faktor individu dalam organisasi
Authors: harmayani
Published: December 2021

faktor individu dalam organisasi
Budaya Sebagai Salah Satu Pembentukan Iman Kristen Seorang Anak
Authors: Monang Widia Lilis
Published: December 2021

Artikel ini membahas sejauh mana budaya itu berperan dalam pembentukan iman kristen seorang anak. Yang mana melihat kenyataan yang terjadi sekarang ini, bahwa pendidikan (Kristen) yang diberikan kepada seorang anak hampir sepenuhnya diserahkan kepada lembaga pendidik secara khusus sekolah dan gereja yang menerapkan bentuk ajaran yang hanya bersumber dari Alkitab. Dalam artikel ini kemudian dibahas bahwa rupanya budaya ini juga dapat membantu dalam hal memberikan didikan yang telah di ajarkan secara turun-temurun yang dipercaya dapat membantu pembentukan iman Kristen bagi seorang anak.
Kebudayaan dan Kapitalisme (Studi Buruh Tenun Pandai Sikek)
Authors: G Jonson Handrian
Published: December 2021

Pernyataan Marx yang mengatakan bahwa sejarah manusia pada dasarnya adalah sejarah pertentangan kelas, merupakan sumber insprirasi bagi saya untuk melihat berbagai fenomena sosial. Kegigihan Marx untuk mengkritik rezim Kapitalisme bukan tanpa hasil, banyak karya-karya penting lahir dari tangannya. Meskipun Marx mendapatkan kritik dari berbagai arah, namun ide-ide dan gagasan yang dirumuskannya mampu menembus dimensi waktu sampai seabad lebih dan masih relevan untuk menjelaskan realitas saat ini. Pada dasarnya, Ajaran Marx adalah ideologi kelas pekerja, expresi teoritis dari kepentingankepentingan dasarnya; itu merupakan ilmu pengetahuan dari perubahan revolusioner dunia.
The Relationship of Indonesian Language Learning with the Environment
Authors: Rosa Aprilia
Published: December 2021

In the world of education there is a learning process carried out by teachers and students. Without the learning carried out by the teacher, of course students will not gain knowledge and experience about various things. The learning process is basically to develop the activities and creativity of students, through various interactions and learning experiences. However, in practice it is often not realized that there are still many learning activities that are carried out which actually hinder the activity and creativity of students. The learning process in the classroom generally emphasizes the cognitive aspect, so that the mental abilities learned are mostly centered on understanding knowledge and memory materials. In such situations, students are usually required to accept what is considered important by the teacher and memorize it. Teachers generally don't like the learning atmosphere where the students ask a lot of questions outside the context being taught. Seeing such conditions, the activities and creativity of students are hampered or cannot develop optimally.
Keteladanan karakter tokoh Rut sebagai perempuan yang beriman
Authors: Elentika
Published: December 2021

Karakter seorang wanita yang patut untuk kita ikuti dan teladani ialah Rut
PEMODELAN MATEMATIKA TERHADAP KESTABILAN POPULASI MODEL LOTKA-VOLTERRA DENGAN BANTUAN MATLAB
Authors: Tambunan Ruth Margaretha
Published: December 2021

Perkembangan IPTEK sekarang ini telah memberikan kemudahan berbagai penelitian. Salah satunya adalah perhitungan masalah sehari-hari dengan pembuktian teorema-teorema baru. Hal ini memungkinkan para peneliti juga untuk mengembangkan teorema matematika yang sudah lama tidak tuntas. Tujuan dari penelitian ini adalah membuat pemodelan dan simulasi matematika tentang Kestabilan populasi model lotka-volterra menggunakan alat bantu aplikasi Matlab R2010a. Pemodelan Matematika terkait model Predator-Prey atau Lotka-Volterra dapat dianalisis dengan perhitungan pada Matlab. Untuk mendefinisikan variable - variabel atau mengeksekusi program dalam MATLAB, maka dapat dilakukan pada ruang “Command Window”, di mana ruang ini dapat ditutup, restore dan resize ruang window-nya. Kita dapat mengamati perubahan laju pertumbuhan kedua populasi untuk berbagai kondisi.
“IMPLEMENTASI PENDIDIKAN YANG TIDAK EFEKTIF DI KALANGAN MAHASISWA AKIBAT DARI COVID-19”
Authors: LIMBONG SELMI DATU
Published: December 2021

ABSTRAKSELMI DATU LIMBONG: Pendidikan yang tidak efektif akibat dari covid 19 Penulisan ini bertujuan mengungkapkan (1) Untuk mengetahui arti pendidikan (2) untuk mengetahui akibat atau dampak negative dari covid-19. Penulisan ini merupakan kemampuan dalam memberikan deskripsi verbal mengenai pendidikan yang tidak efektif di lingkungan mahasiswa di tengah-tengah wabah pandemic-19. Mengapa di katakan tidak efektif? karena yang pertama dengan adanya covid-19 ini banyak orang tua mahasiswa yang kehilangan perkerjaannya sehingga mereka tidak mampu untuk membiayai pendidikan anaknya, yang kedua karena pendidikan sekarang berbasis online, sehingga tidak banyak dari siswa atau mahasiswa yang bemasa bodoh untuk sekolah/kuliah. Akibatnya, banyak dari mereka yang tertidur pada saat pembelajaran sedang berjalan atau bahkan ada yang kasih menyala kamera lalu yang lainnya di kerjakan, sehingga mereka tidak mengerti apa yang di katakana oleh pendidik kepada mereka.Namun disisi lain covid-19 juga tidak hanya membawa pengaruh yang negatif di kalangan masyarakat terutama bagi anak sekolah atau mahasiswa, ada juga hal-hal positif yang di bawa oleh covid -19 slaah satunya ialah membuka wawasan anak sekolah atau mahasiswa secara luas tentang berbagai macam alat teknologi yang dapat di gunakan dalam proses pembelajran daring. kata kunci:pendidikan, efektif, covi-19
ANALISIS TENTANG HIBAH DAN KORELASINYA DENGAN KEWARISAN DAN PEMBATALAN HIBAH MENURUT PERATURAN PERUNDANG-UNDANGAN DI INDONESIA
Authors: Sadi Mohammad Miftahus , K Rachmad Risqy
Published: December 2021

Analisis hibah dan Korelasinya dengan Kewarisan
Pembelajaran Berbasis GBL (Game Based Learning) Guna Menciptakan Suasana Menyenangkan Bagi Siswa
Authors: Ningsih Rahma Yulia
Published: December 2021

Pada aktivas belajar mengajar, siswa memiliki kemampuan yang berbeda-beda dalam menangkap materi pembelajaran yang diajarkan. Oleh karena itu perlu adanya suatu metode yang baik agar suasana dalam pembelajaran tidak membosankan bagi siswa. Dizaman yang semakin canggih ini banyak sekali produk-produk hiburan yang bermunculan diantaranya yaitu games, dan ini sangat berdampak baik terutama dibidang pendidikan.
BELAJAR AKTIF, KREATIF, DAN EFEKTIF PADA MATERI MENILAIN PUISI SECARA ONLINE
Authors: Fitri Elza Adila
Published: December 2021

Aktivitas pembelajaran merupakan suatu kegiatan timbal balik antara pendidik dengan peserta didik. Pembelajaran ialah proses hubungan yg ditandai adanya ekuilibrium antara peserta didik serta pendidik. peristiwa pembelajaran terjadi jika siswa secar aktif berinteraksi terhadap lingkungan belajarnya. Tugas utama di pendidik merupakan mengajarkan siswa, yang dimana melihat kondisi siswa tadi. supaya belajarnya lebih aktif sehingga potensi dirinya (kognitif, afektif dan psikomotor) berkembang dengan maksimal.
Pola kepemimpinan laki-laki dan perempuan dalam ruang lingkup gereja
Authors: Milgasrial
Published: December 2021

Artikel ini membahas tentang sistem kepemimpinan antara laki laki dan perempuan dalam suatu komunitas Gereja. Metode yang digunakan adalah metode deskriptif. Tujuan penelitian ini adalah untuk mengetahui sampai dimana kekuatan Gereja dalam menerima seorang pemimpin yang tidak dilihat dari Gender-nya.
Analisis Kunci Pendidikan Bagi Anak (Peranan Orang Tua dan Konsep Keteladanan)
Authors: Sewanglangi Rosinta Sakke
Published: December 2021

Pendidikan formal tidak sepenuhnya memberikan ilmu bekerja yang sesungguhnya, maka dari itu pendidikan formal tidak selalu menjadi jaminan bagi kesuksesan seseorang. Ilmu itu tidak hanya bisa didapat dari pendidikan formal saja, seseorang yang tidak berpendidikan tinggi atau formal dapat memperoleh berbagai ilmu dari pengalaman dan lingkungan sekitar kehidupannya. Orang tua adalah pendidik pertama yang sangat dibutuhkan dalam perkembangan pribadi dan karakter anak. Untuk membentuk pribadi dan karakter pada anak perlu diiringi dengan karakter yang memberikan contoh atau keteladanan yang baik. Setiap zaman memiliki masalah dan situasi yang berbeda karena itu pendidikan harus disesuaikan dengan kebutuhan zaman.
Pembelajaran Daring Pada Materi Teks Prosedur Bahasa Indonesia
Authors: Imayana
Published: December 2021

Sejak Indonesia dilanda pandemic covid-19 dikeluarkannya kebijakan pemerintah melalui Kementrian Pendidikan dan Kebudayaan bahwa seluruh kegiatan pendidikan dilaksanakan secara dalam jaringan dengan memanfaatkan berbagai teknologi yang tersedia. Ini tentunyu menuntut guru untuk mampu beradaptasi dan menemukan model pembelajaran yang selaras dengan teknologi yang digunakan.Pembelajaran daring atau e-learning merupakan bentuk perkembangan teknologi informasi yang dapat dimanfaatkan sebagai media pembelajaran. Pembelajaran daring diartikan sebagai suatu jaringan computer yang saling terkoneksi dengan jaringan computer lainnya ke seluruh penjuru dunia. Aplikasi e-learning ini dapat memfasilitasi aktivitas pelatihan dan pembelajaran serta proses belajar mengajar secara formal maupun informal, selain juga memfasilitasi kegiatan dan komunitas pengguna media elektronik. Kegitan pembelajaran online ini dilakukan untuk menggantikan pembelajaran secara langsung, atau saat ini beralih pada istilah pembelajaran jarak jauh.Dapat kita lihat bahwa banyak sekali terjadi kendala-kendala pelaksanaan pembelajaran daring yang perlu perhatian lebih oleh guru sebagai tenaga yang mentransferkan ilmu kepada peserta didik. Terdapat banyak sekali keluhan peserta didik yang dapat kita lihat pada berita-berita online, terlebih lagi ada petisi dari para peserta didik menuntut pembelajaran tatap muka segera dilaksanakan. Yang sering dieluh-eluhkan oleh peserta didik banyaknya tugas, keluhan datang dari orang tua yang perihatin terhadap pemahaman anaknya, serta hilangnya kreativitas peserta didik.Dalam mata pelajaran Bahasa Indonesia pada materi teks prosedur diperlukan pemahaman mengenai pengertian, struktur, ciri-ciri, dan contoh teks prosedur, yang menggunakan media ataupun secara manual dalam praktikum teks prosedur yang dilakukan secara berkelompok. Namun pada masa pandemi Covid-19 ini di perlukan inovasi dengan tindakan memberikan pemahaman terkait teks prosedur dengan memberikan pembelajaran secara daring menggunakan aplikasi belajar online yang tersedia. Inovasi ini juga akan lebih inovatif dan efisien yang dapat kita lihat dari segi praktik teks prosedur. Hal ini akan memudahkan siswa dan siswi secara individu dapat mencapai pembelajaran peta dengan sempurna.Penulis membuat tulisan ini dengan merujuk pada pelaksanaan pembelajaran daring sebagai acuan. penulis bertujuan agar pelaksanaan pembelajaran daring dapat terlaksana dengan optimal sehingga peserta didik dapat menyerap ilmu dengan sebaik-baiknya.
IMPLIKASI MUSYARAKAH MUTANAQISAH DALAM PERBANKAN SYARIAH
Authors: Faqih Muhammad
Published: December 2021

Untuk mengetahui pengaruh akad musyarakah mutanaqisah di perbankan syariah
Dilematis Pelayanan Pemberkatan Nikah Dibawa Umur
Authors: Grace Alan
Published: December 2021

Menunjukkan adanya fenomena dalam gereja yang sering terjadi tentang pernikahan dibawah umur dan pelayanan pemberkatan nikah bagi mereka tidak dilakukan oleh majelis gereja
Differential expression of abnormal spindle microtubule assembly in triple negative breast cancer.
Authors: Mamoor Shahan
Published: December 2021

Women diagnosed with triple negative breast cancer can benefit neither from endocrine therapy nor from HER2-targeted therapies (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding abnormal spindle microtubule assembly, ASPM, when comparing the tumor cells of patients with triple negative breast cancer to normal mammary ductal cells (2). ASPM was also differentially expressed in bulk tumor in human breast cancer (3). ASPM mRNA was present at significantly increased quantities in TNBC tumor cells relative to normal mammary ductal cells. Analysis of human survival data revealed that expression of ASPM in primary tumors of the breast was correlated with recurrence-free survival in patients with basal-like and luminal A type cancer, while within triple negative breast cancer, primary tumor expression of ASPM was correlated with overall survival in patients with basal-like 1 subtype disease. ASPM may be of relevance to initiation, maintenance or progression of triple negative breast cancers.
RELEVANSI BUDAYA DAN PENDIDIKAN KRISTEN DALAM PEMBENTUKAN KARAKTER ANAK DAN PERAN MANUSIA SECARA BIOLOGIS
Authors: Penina
Published: December 2021

beberapa ide pemikiran terkait dengan perkembangan pendidikan kristen yang mampu membentuk karakter anak, sinkronisasi budaya Toraja dan peranan manusia (laki-laki dan perempuan) dalam pengembangan nilai-nilai kekristenan dimasyarakat. Tujuan dari pembuatan artikel ini yaitu untuk mengetahui peran pendidikan kristen terhadap pembentukan karakter anak, Untuk mengetahui sinkronisasi pendidikan kristen dan budaya masyarakat Toraja sebagai pusat peradaban kristen di Indonesia sehingga memberikan kontribusi bagi perkembangan kekristenan di Indonesia dan untuk mengetahui tendensi laki-laki dan perempuan terhadap perkembangan pendidikan kristen di masyarakat
Mengenal Kunci Pembentukan Iman Bagi Anak Dalam Keluarga
Authors: Rando Ventrysia Sampe
Published: December 2021

Keluarga adalah sebagai pusat pembentukan aman dan karakter seorang anak, adalah sesuatu hal yang tidak bisa diragukan lagi ataupun membutuhkan pengujian. Akan tetapi perlu saat ini adalah menyadarkan keluarga-keluarga Kristen untuk menyadari hal tersebut. Sehingga mereka mampu mengambil tugas dan tanggung jawab tersebut dalam rangka mempersiapkan generasi penerus gereja dan bangsa ini. hal inilah yang mendasari karya ilmiah ini, dengan mendasari dengan satu harapan akan bermanfaat bagi keluarga-keluarga Kristen untuk lebih mengambil bagian di dalam menyongsong masa depan yang lebih baik.
Guru Sebagai Tenaga Pendidik Yang Menyenangkan Dalam Menciptakan Pembelajaran Kreatif dan Inovatif Bagi Peserta Didik
Authors: NURFATIN SITI
Published: December 2021

Mengajar bukan lagi usaha menyampaikan ilmu pengetahuan, melainkan usaha menciptakan sistem lingkungan yang membelajarkan peserta didik agar tujuan pengajaran dapat tercapai secara optimal. Mengajar dalam pemahaman ini memerlukan suatu strategi yang tepat bagi tujuan yang ingin dicapai untuk itu perlu dibina dan dikembangkan kreativitas guru dalam mengelola program pengajaran dengan strategi belajar mengajar dengan berbagai variasi.
Does third-party punishment in children aim at equality?
Authors: Lee Young-eun , Warneken Felix
Published: December 2021

Third-party punishment has been regarded as an important mechanism to promote fairness.While previous research has shown that children aged 6 and older punish unfair behaviors at a personal cost, it is unknown whether they actually intend to establish equality or whether equality is a mere byproduct of punishment. In this pre-registered study, N = 60 5-to-9-year-olds witnessed that an agent made unfair resource allocations to a peer. Children could then decide not only whether to punish but also how much to punish. We found that with age, children’s intervention is more likely to equalize outcomes between third parties (e.g., turning 3:1 into 1:1). In conclusion, the egalitarian motive to reduce differences in payoffs could underlie children’s punishment over development.
PENDIDIKAN KRISTIANI DALAM MENGGUNAKAN MEDIA SOSIAL BAGI ANAK-ANAK DI TORAJA
Authors: kuse Meli'
Published: December 2021

Sosial media, which is a big thing, really shapes society, especially for children invarious ways, but unfortunately social media is actuality a bad thing for a chil who uses it wrong. The damage to the character of children, the existence of eary marrages that so many occur in Toraja and many other bad things that can cause it. And to overcome this, the role of a C hristian educator must really carry out the tasks carry out with full responsibility, patience and in accordance with the teachings of Chris.
Studi Fenomenologi Tentang Keterlibatan Orang Kristen Dalam Ritus Ma'ban Manuk Dalam Aluk Todolo
Authors: juneta Joice Pratiwi
Published: December 2021

ABSTRAK Ritual/ ritus yaitu serangkaian kegaiatan atau tindakan, biasanya dalam bidang keagamaan yang dilaksanakan dan diatur oleh masyarakat, maknanya maupun cara melakukannya berbeda dengan kehidupan sehari-sehari. Ritus ma’ban manuk merupakan kegaiatan aluk todolo dalam dukacita atau kematian dengan tujuan memberikan makanan kepada arwah yang telah meninggal yang dalam bahasa Toraja disebut ma’ pakande bombo. Namun seiring dengan waktu masyarakat sudah banyak yang menganut agama kristen akan tetapi masih ada beberapa orang kristen yang masih terlibat atau melakukan ritus dimana ritus ini bertentangan dengan pengajaran iman Kristen karena memberikan makan kepada arwah merupakan salah satu penyembahan berhala. Melihat permasalahan di atas, maka penulis terdorong untuk membahas topik ini dengan mengkaji lebih jauh masalah tersebut. Dalam penulisan ini metode yang digunakan yaitu, pendekatan fenomenologi, dari informasi bahwa ma’ban manuk yang dilakukan merupakan salah satu penyelesaian ritus kematian dalam aluk todolo sebagai bentuk memberikan makanan keppada arwah-arwah orang telah meninggal (ma’pakande bombo). Adapun tujuan mengapa orang Kristen masih terlibat dalam ritus ma’ban manuk dalam aluk todolo yang merupakan hal yang bertentangan dengan pengajaran iman Kristen. Dengan demikian bisa dipahami penyebat keterlibatan mereka.
DAMPAK PERCERAIAN ORANG TUA TERHADAP PENBENTUKAN KARAKTER ANAK
Authors: Bandaso Magdalena Pura
Published: December 2021

Pernikahan adalah sebuah tindakan Mulia, tidak boleh dirusak oleh hal-hal sepele.. Pada dasarnya semua ajaran agama Perceraian tidak diperbolehkan. Oleh karena itu, umat Kristen dianjurkan menjaga integritas, Keharmonisan keluarga dapat menyelesaikan masalah yang ada Dengan cara damai, agar tidak terjadi perceraian. Faktor perceraian Itu adalah faktor biologis, faktor psikologis, faktor moral, faktor ekonomi, faktor sosiologis. Akibat dari perceraian ini, anak bisa mengalami kesehatan mental dari dalam dirinya sendiri, kesehatan mental dapat memberikan dampak yang buruk bagi sang anak.
PERAN PENDIDIKAN DALAM BUDAYA TORAJA
Authors: Tale' Densa
Published: December 2021

Pendidikan dan kebudayaan merupakan dua hal yang memiliki keterkaitan dimana dengan adanya pendidikan dapat membentuk manusia mengenal budaya dan dengan budaya pun dapat menuntun manusia untuk hidup sesuai dengan norma yang dijadikan pedoman dalam kehidupannya.Pendidikan selalu berubah dari masa ke masa sesuai dengan perkembangan kebudayaan dan pendidikan ini diharapkan mampu membentuk karakter masyarakat karena sejatinya pendidikan belum pantas disebut pendidikan apabila masih mengabaikan pembentukan karakter karena inilah yang akan menunjang manusia dalam berpendidikan terutama dalam budaya masyarakat toraja yang selalu dituntut dari perubahan zaman