bluuebunny/crossref_metadata_2025 huggingface dataset:
Educational Cyber–Physical Systems (ECPSs) for University 4.0
Authors: Gallon Laurent , Salameh Khouloud , Chbeir Richard , Bachir Samia , Aniorté Philippe
Published: December 2024

University 4.0 represents the adaptation of the Education 4.0 paradigm to the university context. The core principle is the automated supervision of the entire student learning process by an AI-driven computer assistant, allowing for timely adjustments based on the student’s progression. Critical to this process is the assistant’s ability to collect comprehensive information on all student activities within the curriculum, particularly overseeing pedagogical activities in real time to make necessary adaptations. This utilizes Educational Cyber–Physical Systems (ECPSs) to gather all relevant data and extract appropriate information effectively. This article examines a specific case of practical work involving students at two distinct geographical locations collaborating in a blended learning environment. A specialized ECPS is deployed to collect data from equipment at both sites, enabling the modeling of the pedagogical sequence, the cyber–physical system, and the data necessary for monitoring student progress in real time.
Invasion History and Dispersion Dynamics of the Mediterranean Fruit Fly in the Balkan Peninsula
Authors: Bjeliš Mario , Rodovitis Vasilis G. , Lemic Darija , Kaniouras Pantelis , Gančević Pavao , Papadopoulos Nikos T.
Published: December 2024

The Mediterranean fruit fly (medfly), Ceratitis capitata (Wiedemann 1824; Diptera, Tephritidae), is considered one of the most important pests, infesting more than 300 species of fresh fruit and vegetables worldwide. The medfly is an important invasive species, which has spread from the eastern part of sub-Saharan Africa to all of the world’s continents in recent centuries. Currently, the medfly is expanding its geographical range to cooler, temperate areas of the world, including northern areas of Mediterranean countries and continental areas of Central Europe. We collected and analysed all the available information, including in historical records, on the phenology of the medfly in the Balkan Peninsula, to map and understand the path of invasion and spread dynamics on the northern Mediterranean coast and in Central Europe. The medfly was first recorded in the Balkan Peninsula in 1915, in the Aegean area on the island of Aigina, followed by a few records on its presence in the Peloponnese in the early 1930s and throughout the Adriatic coastal area in the 1950s; it was first detected on the Croatian coast in 1947. By 2010, the medfly had been detected along the entire Ionian coast, while the first record of its presence on the Balkan coast of the Black Sea was made in 2005. Since 2000 to date, there has been a significant increase in the frequency of medfly detections in the interior of the Balkan Peninsula, including occasional detections in areas with unfavourable climatic conditions for overwintering, which seems to be favourable for reproduction during the summer and lead to significant infestation of late ripening fruits (late summer and autumn). In the last 20 years, the medfly has spread to more northerly areas (43 to 45 degrees latitude) and has been detected at higher altitudes (>200 to 600 m). Along the Balkan Peninsula, the infestation of fruits from 25 host plant species, from 14 genera and 10 plant families, has been reported. Considering the extremely high invasiveness of the medfly and its wide distribution in several Balkan regions with different climatic conditions, we can assume that it is adapting to new climatic conditions and infesting new host plants.
The Effect of Spray Regimes on the Population Dynamics of Selected Field Pests and Their Effect on Grain Yield and Yield Components of Common Bean in Uganda
Authors: Halerimana Charles , Kyamanywa Samuel , Otim Michael H.
Published: December 2024

In Uganda, the common bean (Phaseolus vulgaris) is often infested by a complex of insect pests, but bean flies, aphids, bean leaf beetles, and flower thrips are the most important. Whereas yield losses due to these pests have been established, there is limited information on their population dynamics at different stages of crop growth and their effect on yield and yield components. In order to describe the population dynamics of selected common bean pests at various phases of bean crop growth, and their impact on yield and yield components, a study was carried out in Uganda during the 2016 second rains and the 2017 first rains in three agro-ecological zones. Bean flies, bean aphids, bean leaf beetles, whitefly, striped bean weevil, leafhoppers, and caterpillars were the main insects observed. Pesticide spray schedules were imposed to generate different populations of insect pests whose effects on yield and its components were determined. The findings indicate that spray regimes significantly influenced the abundance of bean flies and leafhoppers, but not the other insect pests. Additionally, except for caterpillars, insect pests were significantly influenced by crop growth stages, but only leafhoppers exhibited a significant negative relationship with grain yield. Furthermore, yield and yield components varied significantly between spray regimes, and there was a significant positive relationship between grain yield and yield components. Our study is important for informing growers on the stage of crop growth at which management tactics such as use of insecticides can be applied for different insect pests.
Dickkopf 3 as a New Monitoring Tool for Kidney Function After Living Kidney Donation
Authors: Schuster Antonia , Steines Louisa , Banas Bernhard , Bergler Tobias
Published: December 2024

Background: Even today, a non-invasive biomarker to identify donors with enhanced risk for renal impairment is missing. Dickkopf 3 (DKK3) can cause tubulointerstitial fibrosis and is associated with rapid eGFR loss. The aim of our work was to analyze whether DKK3 can be used as a non-invasive alert marker for an increased risk of loss of kidney function in living kidney donors (LKDs). Methods: All donors who were examined between July 2022 and June 2023 (n = 117) were included. DKK3 was measured in the urine. The collected patient-related data were compared with parameters before donation. The study cohort was stratified by DKK3 values (</≥200). Results: In the follow-up, 89 donors had a DKK3 value < 200 (group 1) and 28 donors had a DKK3 value ≥200 (group 2). During post-donation follow-up, renal function in group 1 was significantly better than that in group 2 (p = 0.01), although no difference in renal function before donation was detected (p = 0.84). Group 2 showed also a greater eGFR loss over time than group 1. Conclusions: LKDs with elevated DKK3 levels in the FU had impaired kidney function without evidence of increased risk factors pre-donation. DKK3 can represent a possible monitoring tool for kidney function in LKDs.
Allograft Bone Screw in a Comminuted Hawkins III Talar Neck Fracture: Case Report
Authors: Huetter Konstanze , Holweg Patrick , Ornig Martin , Labmayr Viktor
Published: December 2024

Background: Talar neck fractures are complex injuries that become particularly challenging when accompanied by bone loss or comminution. This case report introduces the use of an allograft bone screw as a novel method for bridging lateral comminution at the talar neck, providing structural support and promoting bone regeneration. Methods: A 20-year-old male sustained a comminuted talar neck fracture with subtalar and tibiotalar dislocation after a bouldering fall. Urgent surgical intervention involved open reduction and internal fixation using a two-incision technique. The medial key fragment was stabilized with two conventional compression screws, revealing a significant lateral bony defect. This was bridged and stabilized with an allogeneic cortical bone screw (Shark Screw®, Surgebright GmbH, Lichtenberg, Austria), supplemented by bone replacement material. Results: At three months, CT confirmed fracture healing, and weight-bearing was initiated. At six months, the AOFAS score was 85/100 and FAAM 69/84, with no significant pain or swelling. By one year, the patient demonstrated full weight-bearing with occasional pain (AOFAS 88/100, FAAM 79/84). At two years, the patient achieved a pain-free range of motion and full activity participation (AOFAS 100/100, FAAM 83/84). Conclusions: The successful application of this technique illustrates the potential of allograft bone screws for stabilizing and bridging defects in talar neck fractures.
Systematic Intravenous Administration of Autologous Mesenchymal Stem Cells Is Safe
Authors: Matsuoka Takaaki , Itohara Takaaki , Hara Yurie , Kobayashi Nana
Published: December 2024

Background: Mesenchymal stem cells (MSCs) have drawn significant attention for their regenerative potential and therapeutic applicability across a range of conditions, including cardiovascular diseases and age-related frailty. Despite extensive preclinical studies, there remain gaps in understanding the long-term safety and efficacy of MSC therapy in humans. This study aimed to assess the safety of intravenous MSC administration, evaluate the mean major adverse cardiac and cerebrovascular event (MACCE)-free period, and identify potential risk factors for MACCE development in patients receiving MSC therapy for various indications. Methods: A retrospective observational study was conducted on 2504 patients (mean age: 54.09 ± 11.65 years) who received intravenous adipose-derived MSC (AD-MSC) therapy between October 2014 and December 2023 at the Omotesando Helene Clinic, Tokyo, Japan. Patients received MSC doses ranging from 100 million to 2 billion cells, with the majority receiving 1–2 billion cells per treatment. Statistical analyses included multivariate Cox proportional hazards regression and Kaplan–Meier survival analysis to evaluate MACCE risk factors and event-free duration. Results: Over the follow-up period, the MACCE rate was exceptionally low at 0.2%. Multivariate analysis identified age as a significant risk factor for MACCE (hazard ratio: 1.127; 95% CI: 1.0418–1.219; p = 0.0029), while sex and MSC dose showed no significant association. Minor adverse events occurred in 0.8% of patients, with no severe adverse events reported. The study found MSC therapy to be safe, with a low adverse event rate and minimal risk of MACCE. Conclusions: This study demonstrates the safety of intravenous MSC therapy in a large cohort of patients, with a low incidence of MACCE and minimal adverse effects. Age was the only significant predictor of MACCE risk. Further prospective randomized studies are needed to validate these findings and explore the potential of MSC therapy in reducing MACCE risk and improving clinical outcomes across diverse indications.
Efficacy of Transcutaneous Pulsed Radiofrequency Treatment in Subacromial Impingement Syndrome: A Randomized Controlled Study
Authors: Utkan Karasu Ayça , Kılıç Ayza , Karaoğlan Belgin
Published: December 2024

Background: This study assessed Transcutaneous Pulse Radiofrequency Therapy’s (TCPRF) effectiveness in reducing shoulder pain and improving shoulder function. Methods: A double-blind randomized controlled trial involved 50 SAIS patients with chronic shoulder pain. Participants were randomized into two groups: the study group (n = 27) received TCPRF, while the control (n = 23) received sham treatment. The primary outcome was shoulder pain, secondary outcomes, including shoulder function, quality of life, and range of motion, were assessed at baseline, and at 1, 4, and 12 weeks using the Visual Analog Scale (VAS), Shoulder Pain and Disability Index (SPADI), and the SF-36 questionnaire. Supraspinatus tendon thickness (SSPT) and acromiohumeral distance (AHD) were measured by ultrasound. Results: Both groups showed reductions in activity and resting pain over 12 weeks. In the control, activity pain dropped from a median (IQR) of 8 (7–8) to 6 (3–7), and in TCPRF from 8 (7–10) to 3.5 (2–6.3), with no significant difference at 12 weeks (p = 0.192). Resting pain decreased from 3 (1–6) to 1 (1–3) in the control, and from 3 (2–4) to 0 (0–2) in TCPRF, showing a lower resting pain at 12 weeks (p = 0.041). SPADI-Total scores decreased from 87 (54–105) to 50 (29–82) in the control and from 84 (69–107) to 21 (9–66.3) in TCPRF, favoring TCPRF at 12 weeks (p = 0.017). SPADI–Disability scores reduced from 49 (30–63) to 30 (15–30) in control and from 47 (35–62) to 11 (5.8–38.8) in TCPRF, also favoring TCPRF (p = 0.008). Both groups showed similar improvements in other outcomes. Conclusions: TCPRF reduced resting pain and shoulder disability in SAIS over 12 weeks, though other outcomes showed similar improvement in both groups. Further studies are needed to determine long-term effects.
Diagnostic Usefulness of Serum Hyaluronic Acid in Patients with SARS-CoV-2 Infection
Authors: Cylwik Bogdan , Gan Kacper , Kazberuk Marcin , Gruszewska Ewa , Panasiuk Anatol , Chrostek Lech
Published: December 2024

Background/Objective: The aim of our study is to comprehensively assess the diagnostic usefulness of serum hyaluronic acid (HA) determination in COVID-19 patients. Methods: The study group included 87 patients with COVID-19 disease and 45 healthy subjects. The HA concentration was measured using the immunochemical method. Results: The serum HA concentration was significantly higher in the COVID-19 patients before admission to hospital than that in the controls (p < 0.001). Differences were found in HA levels between the groups categorized according to disease severity (p = 002), being significantly higher in patients with critical as compared to moderate disease severity (p < 0.001). The HA concentration varied depending on the type of oxygen therapy (p = 0.004). It was significantly higher in patients on a ventilator than in those without oxygen therapy (p = 0.002). In patients who qualified for the steroid treatment and immunotherapy, the HA levels were significantly higher compared to those who did not qualify for such therapies (p = 0.043, p = 0.049, respectively). The HA levels were significantly higher in patients with cytokine storm compared to those without it (p < 0.001) and were significantly more elevated in non-survivors than in survivors (p < 0.001). HA had an excellent diagnostic power (AUC = 0.994) with sensitivity (83.3%) and specificity (97.8%) in identifying patients with critical disease severity and an excellent diagnostic power (AUC = 0.932) with sensitivity (88.2%) and specificity (95.6%) in identifying non-surviving patients. Conclusions: In summary, the results of our study indicate that HA is closely associated with severe SARS-CoV-2 infection and could be used as a novel serum biomarker to predict the risk of disease progression and as a predictor of COVID-19 mortality.
PIK3CA Mutations and Co-Mutations in Operated Non-Small Cell Lung Carcinoma
Authors: Cokpinar Salih , Erdogdu Ibrahim Halil , Orenay-Boyacioglu Seda , Boyacioglu Olcay , Kahraman-Cetin Nesibe , Meteoglu Ibrahim
Published: December 2024

Background: Understanding PIK3CA mutations and co-mutations in non-small cell lung carcinoma (NSCLC) is critical to developing personalized treatment strategies. Therefore, this study aims to investigate PIK3CA mutations and the accompanying somatic variations in NSCLC. Methods: This retrospective study included 98 patients over 18 years of age who were diagnosed with NSCLC, operated on, and referred to the Molecular Pathology Laboratory between January 2019 and June 2024 for next-generation sequencing panel tests and ALK-ROS1 FISH analysis. Results: All patients were found to carry PIK3CA mutations. Among the 98 NSCLC patients analyzed, 16 (16.33%) were female and 82 (83.67%) were male. The average age of the patients was 64.53 ± 9.63 years, with an age range of 38–84 years, and the majority were 50 years or older. Of the cases, 51 presented the adenocarcinoma subtype, while the remaining 47 showed the squamous cell carcinoma subtype. A smoking history was present in 77 (78.57%) patients, while 21 (21.43%) had no smoking history. The most frequently detected pathogenic or likely pathogenic PIK3CA variations were c.1633G>A p.E545K (32.65%), c.1624G>A p.E542K (11.22%), c.3140A>G p.H1047R (11.22%), c.3140A>T p.H1047L (5.10%), c.1357G>C p.E453Q (4.08%), and c.3143A>G p.H1048R (2.04%). The top 10 mutations that most commonly accompanied PIK3CA variations were KRAS, NF1, TP53, EGFR, PTEN, BRAF, KIT, CDKN2A, SMARCA4, and ATM mutations, respectively. Conclusions: PIK3CA variations, along with other gene variations, may influence cancer progression and thus may play a crucial role in the determination of targeted treatment strategies.
Assessing Overweight, Obesity, and Related Risk Factors in 8–9-Year-Old Children in Szczecin, Poland
Authors: Gapińska Irmina , Kostrzeba Ewa , Ratajczak Joanna , Horodnicka-Józwa Anita , Raducha Dominika , Jackowski Tomasz , Walczak Mieczysław , Petriczko Elżbieta
Published: December 2024

Background: Childhood obesity is a significant public health issue. This study aimed to evaluate the prevalence of overweight and obesity among 8- and 9-year-old children in Szczecin, Poland, and unlike other studies to assess differences in nutritional status within a single urban agglomeration of nearly 500,000 residents, it was influenced by place of residence and socioeconomic status. Methods: The study included 4705 children (2327 boys and 2378 girls) aged 8 and 9 years, attending 50 primary schools in Szczecin (45 public, 5 private) across four districts: North, Right Bank, City Center, and West. Anthropometric measurements were used to calculate BMI. Overweight was diagnosed when BMI was ≥85th percentile but lower than the 95th percentile for age and sex, while obesity was when the BMI was ≥95th percentile. Data on parental BMI, education, and place of residence were also collected. Results: The prevalence of overweight was 16.6%, and obesity was 6.2%. Overweight was more common in girls, while obesity was more frequent in boys. Children attending special education schools and living in the Right-Bank district had the highest rates of overweight and obesity. Parental obesity and low parental education, particularly the father’s, were the strongest risk factors for excess body weight. Conclusions: Differences in childhood nutritional status exist even within the same city, influenced by residence and socioeconomic factors. Parental obesity, low education, living in the city’s rural districts, and attending special education schools are key risk factors. Enhanced prevention programs tailored to these factors are crucial to combat childhood obesity effectively.
Factors Associated with the Severity of ERCP-Related Complications: A Retrospective Single-Centre Study
Authors: Goubert Kristel , Degroote Helena , De Vos Martine , Khalenkow Maxim , Hindryckx Pieter
Published: December 2024

Objectives: Risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) complications have been extensively studied and are well established; most complications are mild and self-limiting. This study aims to identify patients at risk of severe early post-ERCP complications. Methods: We conducted a retrospective cohort study with data from 2810 ERCP procedures performed at Ghent University Hospital between 2016 and 2022. Patient records and a maintained ERCP registry were used to identify all ERCP-related complications and possible risk factors. The AGREE classification was used to determine the severity of the complication. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of severe complications. Results: Out of 2810 procedures, 223 cases (7.9%) had post-ERCP complications, with severe complications occurring in 20.3% of cases. The most common severe complication was haemorrhage (22/49 severe complications, 44.9%), with perforation having the highest probability of being severe (10/15 cases, 67%). Independent predictors of severe complications included anticoagulative therapy (OR 6.3, 95% CI 1.4–28.3, p = 0.016) and high procedural difficulty (Schutz category 3: OR 11.5, 95% CI 2.4–54.6, p = 0.002; category 4: OR 5.9, 95% CI 1.4–23.5, p = 0.012). Conclusions: Patients on anticoagulation and those undergoing complex ERCP procedures (Schutz 3 or 4) are at particular risk of severe procedure-related complications.
Neurophysiological Effects of Withdrawal from Acute Overused Medications in Chronic Migraine with Medication-Overuse Headache
Authors: Sebastianelli Gabriele , Casillo Francesco , Abagnale Chiara , Di Renzo Antonio , Ziccardi Lucia , Parisi Vincenzo , Di Lorenzo Cherubino , Serrao Mariano , Coppola Gianluca
Published: December 2024

Background/Objectives: Chronic migraine with medication-overuse headache (CM-MOH) is neurophysiologically characterized by increased cortical excitability with sensitization at both the thalamocortical and the cortical levels. It is unclear whether the increased cortical excitability could be reverted by medication withdrawal (i.e., brain state) or whether it is a brain trait of individuals predisposed to medication overuse. In this study, we aim to investigate whether withdrawal from overused drugs can influence and restore these neurophysiological abnormalities. Methods: Somatosensory evoked potentials (SSEPs) were elicited by electrical stimulation of the median nerve (M), the ulnar nerve (U), and the simultaneous stimulation of both nerves (MU) in 14 patients with CM-MOH before (T0) and after (T1) a three-week withdrawal protocol and, for comparison, in 14 healthy volunteers (HVs) of a comparable age distribution. We measured the level of thalamocortical (pre-HFO) and cortical activation (post-HFO) by analyzing the high-frequency oscillations (HFOs) embedded in parietal N20 median SSEPs. Furthermore, we calculated the habituation and the degree of cortical lateral inhibition (dLI) of N20-P25 low-frequency SSEPs. Results: After the three-week withdrawal protocol (T1), we observed a normalization of the baseline habituation deficit (T0: +0.10 ± 0.54; T1: −0.53 ± 0.8; p = 0.040) and a reduction in the amplitude for both pre-HFO (p < 0.009) and post-HFO (p = 0.042), with values comparable to those of the HVs. However, no effects were observed on the dLI (p = 0.141). Conclusions: Our findings showed that withdrawal from overused drugs could affect the increased excitability of the non-painful somatosensory system in patients with CM-MOH, reducing the level of sensitization at both the thalamocortical and the cortical levels.
Differential Cardiotoxicity of Ibrutinib Versus Chemoimmunotherapy in Chronic Lymphocytic Leukemia: A Population-Based Study
Authors: Majrashi Abdulrahman , Gue Ying X. , Shantsila Alena , Williams Stella , Lip Gregory Y. H. , Pettitt Andrew R.
Published: December 2024

Background: Chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia among adults, particularly in Western nations. The introduction of Bruton’s tyrosine kinase (BTK) inhibitors as a treatment of CLL, namely, ibrutinib, which is a first-generation BTK inhibitor, has significantly improved the treatment landscape for CLL. However, ibrutinib has been associated with an increased risk of atrial fibrillation (AF) and hypertension. Real-world studies that compare the cardiovascular safety of ibrutinib with bendamustine plus anti-CD20 monoclonal antibody are not widely available. Methods: A retrospective cohort analysis using the TriNetX platform identified two patient groups: one treated with ibrutinib and the other with bendamustine and an anti-CD20 antibody. Propensity score matching balanced their demographic and clinical characteristics. The outcomes evaluated included the all-cause mortality and new-onset AF/flutter, hypertension, heart failure, ventricular arrhythmias, and bleeding. Results: No significant difference was observed in the all-cause mortality between the two cohorts. However, ibrutinib was associated with a higher risk of AF/flutter (HR 1.89, 95% CI 1.36–2.62; p < 0.05) and hypertension (HR 1.22, 95% CI 1.01–1.47; p = 0.04). Other outcomes, such as heart failure, ventricular arrhythmias, and bleeding, were not different between the cohorts. Conclusions: Ibrutinib remains a valuable option for the treatment of CLL, but is associated with significant cardiovascular risks, leading to it being superseded by the newer generation of BTKis, which offer less cardiovascular toxicities. These results highlight the TriNetX platform’s reliability as a real-world data source for validating clinical trial findings and highlight the importance of incorporating cardio-oncology into treatment plans for CLL patients with significant comorbidities.
Risk-Averse, Integrated Contract, and Open Market Procurement with Quantity Adjustment Costs
Authors: Mahapatra Santosh , Kar Santosh , Levental Shlomo
Published: December 2024

This paper examines the issue cost-effective procurement of a commodity product when its spot (open) market prices are stochastic, contract prices are previously determined, and there are costs associated with adjusting (i.e., switching) the procurement quantities from an alternative. Spot (open) market and contract as sole modes of procurement could present risks of high magnitude and uncertainty of expenses for the buyer. To address these risks, a risk-averse buyer may consider simultaneous use of both alternatives with adjustment of the purchase quantities from both the alternatives over time. Scenarios when the switching costs depend on the relative prices of the two alternatives are considered. The problem being analytically intractable, a mixed method decision model combining analytical and computational techniques to analyze the problem is proposed. The model helps identify expected optimal contract and spot market procurement quantities with respect to unknown spot prices and known contract prices over the planned procurement horizon when procurement quantity adjustment costs are influenced by the spends. The analysis reveals that it is cost-effective to continue purchasing with an existing pattern of procurement from the two alternatives until the contract to spot market price ratio reaches a threshold level and then to change the proportion of quantity purchased from the two alternatives. Using numerical analysis, we illustrate the theoretical and managerial significance of this stickiness to continue with an existing pattern until an adjustment.
Effects of Temperature and Carrier Gas on Phosphorus Transformation in Biosolids Biochar
Authors: Aktar Shefali , Hossain Md Afzal , Gasco Gabriel , Mendez Ana , de Figueiredo Cicero Celio , Shah Kalpit , Paz-Ferreiro Jorge
Published: December 2024

Phosphorus (P) is an essential macronutrient for plants. The focus of this work is to recover P from biosolids and their derived biochar. The effect of three different pyrolysis temperatures (400 °C, 500 °C, and 600 °C) and two carrier gases (CO2 and N2) on P fractionation and the speciation of P on biochars produced from two biosolids were investigated. The Hedley chemical sequential extraction method and 31P liquid NMR were used for P characterization and quantification. Higher pyrolysis temperatures increased P fixation and decreased short-term P bioavailability. Carrier gas had also significant effects on P fractionation in the biochars. Biochar produced in a CO2 environment had slightly higher water-soluble P, NaHCO3-Pi, NaOH-Pi, and residual P than in biochar prepared in a N2 environment, while HCl-P showed the opposite trend. Additionally, the predominant molecular configuration of P was present in the inorganic form identified by 31P liquid NMR spectra, while organic P transformed into inorganic P with increasing pyrolysis temperature.
The “Culture” of Organs: A Holistic Theory on the Origins of the Cancer Tissue Environment
Authors: Rehnke Robert D.
Published: December 2024

For over a century, the somatic gene mutation theory of cancer has been a scientific orthodoxy. The recent failures of causal explanations using this theory and the lack of significant progress in addressing the cancer problem medically have led to a new competition of ideas about just what cancer is. This essay presents an alternative view of cancer as a developmental process gone wrong. More specifically, cancer is a breakdown in the autopoietic process of organ maintenance and the multicellular coordination of tissues. Breast cancer is viewed through a systems science perspective as an example of the importance of framing one’s theoretical assumptions before making empirical judgments. Finally, a new understanding of the histoarchitecture of the interstitium is presented as a first principle of cancer: a process of cells coming from cells, invading the space between cells.
Management of Secondary Immunodeficiency Following T-Cell-Engaging Immunotherapeutic Agents in B-Cell Non-Hodgkin Lymphoma: Implications for Early-Line Treatment Strategies
Authors: Day William Grant , Heald Jon , Grigsby Sierrah , Beale Peter , Pittman Luke , DeStefano Christin B.
Published: December 2024

Anti-CD19 chimeric antigen receptor (CAR) T-cell and anti-CD20 bispecific antibody therapies (BsAbs) are rapidly moving to earlier treatment lines for patients with B-cell non-Hodgkin lymphoma (B-NHL). The rapid pace of the advancement of these T-cell-engaging therapies is juxtaposed by a lack of a comprehensive understanding of the scope and kinetics of immunodeficiency following these treatments. We review emerging studies detailing the safety and efficacy of CD19 CAR-T and CD20 BsAbs in earlier lines for B-NHL, as well as a discussion of the limited knowledge of immune recovery following these treatments. We integrate the limited consensus prevention and management recommendations, advocating that the management of secondary immunodeficiency following these transformative therapies is an urgent unmet need in immune oncology research. A collaboration between hematologists/oncologists and immunologists in the management of these patients is critical to optimize patient care.
Hydrated Calcium Silicate Erosion in Sulfate Environments a Molecular Dynamics Simulation Study
Authors: You Mengjie , Yin Xiaosan , Sun Yuzhou , Wu Hairong , Li Jimin , Zhou Xiangming
Published: December 2024

To investigate the micro-mechanism of the erosion of hydrated calcium silicate (C-S-H gel) in a sulfate environment, a solid–liquid molecular dynamics model of C-S-H gel/sodium sulfate was developed. This model employs molecular dynamics methods to simulate the transport processes between C-S-H gel and corrosive ions at concentrations of 5%, 8%, and 10% sodium sulfate (Na2SO4), aiming to elucidate the interaction mechanism between sulfate and C-S-H gel. The micro-morphology of the eroded samples was also investigated using scanning electron microscopy (SEM). The findings indicate that the adsorption capacity of C-S-H for ions significantly increases with higher concentrations of Na2SO4 solution. Notably, the presence of sulfate ions facilitates the decalcification reaction of C-S-H, leading to the formation of swollen gypsum and AFt (ettringite). This process results not only in the hydrolysis of the C-S-H gel but also in an increase in the diffusion coefficients of Na+ and Ca2+, thereby exacerbating the erosion. Additionally, the pore surfaces of the C-S-H structure exhibited strong adsorption of Na+, and as the concentration of Na2SO4 solution increased, Na+ was more stably adsorbed onto the C-S-H pore surfaces via Na-Os bonds. The root-mean-square displacement curves of water molecules were significantly higher than those of SO42−, Na+ and Ca2+, which indicated that SO42− could co-penetrate and migrate with water molecules faster compared with other ions in the solution containing SO42−, resulting in stronger corrosion and hydrolysis effects on the C-S-H structure.
About Calculus Through the Transfer Matrix Method of a Beam with Intermediate Support with Applications in Dental Restorations
Authors: Cojocariu-Oltean Otilia , Tripa Mihai-Sorin , Bărăian Iulia , Rotaru Doina-Iulia , Suciu Mihaela
Published: December 2024

This work presents an original and very interesting approach to a calculus problem involving beams with intermediate supports through the transfer-matrix method, a very easy method to program to quickly obtain good results. To exemplify the applicability of this approach in dentistry, the calculus of a dental bridge on three poles is explored. Dental restorations are very important for improving a person’s general state of health as a result of improving mastication and esthetic appearance. The approach used in this study consists of presenting a theoretical study about an indeterminate beam with an intermediate support and then particularizing it for application in a dental restoration case, with a dental bridge on three poles and two missing teeth between the three poles. The bridge is assimilated to a simple static indeterminate beam. This paper is unique in that it involves the application of the transfer-matrix method for a case study in dental restoration. The assimilation of a dental bridge with a statically undetermined beam, resting on the extremities and on an intermediate support, is an original approach. The results obtained in the presented case study were validated by comparison with those obtained through the classical calculation of the Resistance of Materials, with Clapeyron’s equation of three moments. Due to the ease and elegance of solving various problems with the TMM, this approach will continue to be relevant to other original case studies with different modeling requirements, and these applications will be presented in future research.
A Study of the q-Truncated Exponential–Appell Polynomials
Authors: Costabile Francesco Aldo , Khan Subuhi , Ali Hassan
Published: December 2024

This article introduces the 2-variable q-truncated exponential–Appell (q-trunc. exp. Appell) polynomials and investigates their fundamental properties. Specific results are derived for the q-trunc. exp. Appell family along with their graphical representations which contribute to advancing the understanding of q-series and q-special functions. Potential applications of these polynomials span various disciplines, including combinatorics (such as partition theory and combinatorial identities), number theory (such as q-analogues of classical number-theoretic functions), and mathematical physics (such as in quantum groups and statistical mechanics). This study concludes with the introduction of the 2-variable q-trunc. exp. λ-polynomials, thereby broadening the scope and relevance of this research.
Commutative Rings Behind Divisible Residuated Lattices
Authors: Flaut Cristina , Piciu Dana
Published: December 2024

Divisible residuated lattices are algebraic structures corresponding to a more comprehensive logic than Hajek’s basic logic with an important significance in the study of fuzzy logic. The purpose of this paper is to investigate commutative rings whose lattice of ideals can be equipped with a structure of divisible residuated lattice. We show that these rings are multiplication rings. A characterization, additional examples, and their connections to other classes of rings are established. Furthermore, we analyze the structure of divisible residuated lattices using finite commutative rings. From computational considerations, we present an explicit construction of isomorphism classes of divisible residuated lattices (that are not BL-algebras) of small size n (2≤n≤6), and we give summarizing statistics.
Mutual-Energy Inner Product Optimization Method for Constructing Feature Coordinates and Image Classification in Machine Learning
Authors: Wang Yuanxiu
Published: December 2024

As a key task in machine learning, data classification is essential to find a suitable coordinate system to represent the data features of different classes of samples. This paper proposes the mutual-energy inner product optimization method for constructing a feature coordinate system. First, by analyzing the solution space and eigenfunctions of the partial differential equations describing a non-uniform membrane, the mutual-energy inner product is defined. Second, by expressing the mutual-energy inner product as a series of eigenfunctions, it shows the significant advantage of enhancing low-frequency features and suppressing high-frequency noise, compared to the Euclidean inner product. And then, a mutual-energy inner product optimization model is built to extract the data features, and the convexity and concavity properties of its objective function are discussed. Next, by combining the finite element method, a stable and efficient sequential linearization algorithm is constructed to solve the optimization model. This algorithm only solves positive definite symmetric matrix equations and linear programming with a few constraints, and its vectorized implementation is discussed. Finally, the mutual-energy inner product optimization method is used to construct feature coordinates, and multi-class Gaussian classifiers are trained on the MINST training set. Good prediction results of the Gaussian classifiers are achieved on the MINST test set.
Effect of Anion-Conducting Electrolytes in Pore-Filling Membranes on Performance and Durability in Water Electrolysis
Authors: Jeong Dahye , Park Jin-Soo
Published: December 2024

This study examines the effect of the structural characteristics of anion-conducting monomers within pore-filling anion exchange membranes on the performance and durability of anion exchange membrane water electrolysis. Analysis reveals that acrylamide- and acrylate-based membranes show optimal performance without methyl groups, with acrylamide-based membranes outperforming their acrylate counterparts in current density, particularly at 1.8 V. The AC-AA and AC-MAA monomers demonstrate durability, with AC-MAA showing enhanced alkaline stability, likely due to the presence of a methyl group, resulting in an increase rate of 746.6 μV/h compared to AC-AA’s 1150 μV/h. This study also shows that a commercial membrane exhibits a decrease rate of 3116 μV/h, underscoring the pore-filling membrane’s superior durability. Furthermore, the findings highlight that pore-filling membrane technology enables better durability and performance in electrolysis environments compared to the commercial homogeneous membrane, particularly when alkaline conditions are present. This research provides a foundation for designing high-performance, durable membranes for efficient hydrogen production, particularly under water electrolysis conditions.
Insight into the Influence of Cu on the Corrosion Mechanism of 1%Ni Weathering Steel in a Simulated Containing NaCl Atmospheric Environment
Authors: Han Chengliang , Yu Qiang , Wang Shibiao , Qiao Mingliang , Wang Qingfeng
Published: December 2024

It is difficult for traditional weathering steel (WS) to form a protective rust layer to withstand the chloride ions and high humidity. Hence, there is an urgent need to develop a new type of low-cost WS with excellent corrosion resistance in the containing NaCl environment. This study aims to determine the influence of Cu on the corrosion mechanism of 1%Ni WS in simulated containing NaCl atmospheric environments. By increasing the Cu content (0.15–0.55%), the corrosion resistance of WS is enhanced. The increasing Cu content promotes the formation of a stable and compact rust layer, significantly enriching the proportion of α-FeOOH to equip the rust layer with a physical barrier. The formation of CuO deposits in the holes and cracks make the rust layer more compact and uniform. The increased Cu content promotes the formation of CuFeO2 and increases the content of NiFe2O4. The formation of CuFeO2 and NiFe2O4 then equips the rust layer with a chemical barrier. Hence, the addition of Cu could enhance the resistance of 1%Ni WS to containing NaCl atmospheric environments.
Effects of Anisotropic Microstructure and Load Ratio on Fatigue Crack Propagation Rate in Additively Manufactured Ti-6Al-4V Alloy
Authors: Chakotay Elad , Shneck Roni Z. , Golan Oz , Carmi Rami , Mega Mor , Alon Igal , Yakov Raziel , Busiba Arie
Published: December 2024

Additive manufacturing (AM) refers to advanced technologies for building 3D objects by adding material layer upon layer using either electron beam melting (EBM) or selective laser melting. AM allows us to produce lighter and more complex parts. However, various defects are created during the AM process, which severely affect fatigue behavior. In the current research, the effects of the anisotropic microstructure in the in-plane and out-of-plane orientations and defects on the fatigue crack propagation rate (FCPR) and crack path were studied. A resonance machine was used to determine the fatigue crack propagation rate (da/dN vs. ΔK) from the near-threshold up to the final fracture, accompanied by in situ Acoustic Emission (AE) monitoring. Micro-Computerized Tomography (µCT) enabled us to characterize surface and microstructural defects. Metallography was used to determine the microstructure vs. orientations and fractography to classify the fatigue fracture propagation modes. Calculations of the local stress distribution were performed to determine the interactions of the cracks with the defects. In the out-of-plane direction, the material exhibited high fatigue fracture toughness accompanied by a slightly lower fatigue crack propagation rate as compared to in-plane orientations. The near-threshold stress intensity factor was slightly higher in the out-of-plane orientation as compared to that in the in-plane one, accompanied by a lower exponent of the Paris law regime. The threshold decreased with an increasing load ratio as expected for both orientations. The crack propagation direction that crosses the elongated grains plays an important role in increasing fatigue resistance in the out-of-plane direction. In the in-plane directions, the crack propagates parallel to the grain boundary, interacts with more defects and exhibits more brittle striations on the fracture surface, resulting in lower fatigue resistance.
Modeling and Simulation of Fatigue Crack Initiation Process Based on Field Theory of Multiscale Plasticity (FTMP): Part II: Modeling Vacancy Formation and Coupling with Diffusion Analysis
Authors: You Xinping , Hasebe Tadashi
Published: December 2024

Cyclic straining simulations using incompatibility-incorporated crystal plasticity-FEM, which exhibit PSB ladder structure evolutions as detailed in Part I, are coupled with diffusion analyses of produced vacancies. A new vacancy source model is introduced based on the Field Theory of Multiscale Plasticity (FTMP), interpreting the relationship between the incompatibility rate and the flux of dislocation density as edge dipole annihilation processes. Both direct and indirect coupling diffusion analyses, with and without cyclic straining, demonstrate that varying incompatibility rates tend to further promote vacancy diffusion, leading to surface grooving, enhanced extension rates, and eventual transition to cracks. The findings reveal that (i) the evolved PSB ladder structure serves as a site for vacancy formation, (ii) it provides a diffusion path toward the specimen surface, and (iii) it significantly enhances groove extension rates. These factors effectively facilitate the transition from a “groove” to a “crack”, evidenced by the abrupt acceleration of the extension rate, mirroring systematic experimental observations. These achievements validate the FTMP’s capability to simulate complex phenomena and significantly deepen our understanding of slip band–fatigue crack transition mechanisms.
Role of Milk Intake in Modulating Serum Lipid Profiles and Gut Metabolites
Authors: Xu Ting , Zhang Chang , Yang Yufeng , Huang Liang , Liu Qingyou , Li Ling , Zeng Qingkun , Li Zhipeng
Published: December 2024

Background/Objectives: Milk is one of the main sources of nutrition in people’s daily diet, but the fat in milk raises health concerns in consumers. Here, we aimed to elucidate the impact of Buffalo milk and Holstein cow milk consumption on blood lipid health through metabolomics analysis. Methods: Golden hamsters were administered Murrah Buffalo milk (BM) or Holstein cow milk (HM), and the body weight and serum lipid indicators were tested and recorded. The hamsters receiving equal amounts of physiological saline were used as the negative control (NC). Serum and fecal samples were collected, and LC-MS was used to identify the metabolites in the samples. Results: The results showed that both the BM and HM groups exhibited a significant reduction in body weight compared to that of the NC group from day 9, and the serum TG, TC, and LDL-C levels were significantly lower than those of the NC group. Further analysis identified 564 and 567 metabolites in the serum and fecal samples shared in the BM and HM groups and significantly different from those in the NC group, which were mainly enriched in the pathways related to lipid metabolism, such as fatty acid biosynthesis, arachidonic acid metabolism, and primary bile acid biosynthesis. Correlation analysis further suggested that milk intake can increase the levels of Muramic Acid, Oleoyl Ethanolamide, Seratrodast, Chenodeoxycholic Acid, Docosahexaenoic Acid Ethyl Ester, and Deoxycholic Acid in the serum and gut microbiota, which may affect TG, TC, HDL-C, and LDL-C in the serum, and thereby benefit the body’s lipid health. Conclusions: The results further confirmed that milk intake has a beneficial effect on blood lipid health by altering multiple metabolites in the serum and the gut. This study provides novel evidence that milk consumption is beneficial to health and is a reference for guiding people to a healthy diet.
Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression
Authors: Sun Shujing , Kong Li , Hu Fangting , Wang Sheng , Geng Menglong , Cao Hongjuan , Tao Xingyong , Tao Fangbiao , Liu Kaiyong
Published: December 2024

Background: Our previous study showed that antibiotic exposure was linked to depressive symptomatology in community-dwelling older adults in China. Our current study aims to explore the underlying mechanisms by assessing the intermediated effects of circulating short-chain organic acids (SCOAs) on this association. Methods: Depressive symptoms were screened by the 30-item Geriatric Depression Scale (GDS-30). Urinary concentrations of antibiotics and serum SCOAs were measured using a liquid chromatography–mass spectrometry method. Results: Increased exposure to sulfadiazine, azithromycin, tetracyclines, or veterinary antibiotics (VAs) was positively associated with GDS-30 scores. Tetracycline reduced levels of caproic acid, iso-butyric acid, and iso-caproic acid (iso-CA), with iso-CA concentration inversely correlating with GDS-30 scores, while β-hydroxybutyric acids showed a positive correlation. The mediating effect of serum iso-CA on the association between depression and ofloxacin, with a mediating effect of 25.3%, and the association between depression and tetracycline, with a mediating effect of 46.3%, were both statistically significant, indicating partial mediation. Conclusions: Antibiotics may affect the levels of SCOAs in older adults and could potentially contribute to depressive symptoms by influencing alterations in serum iso-CA levels.