bluuebunny/crossref_metadata_2025 huggingface dataset:
THREE PIGMENTED INDIGENOUS RICE EXTRACTS AS POTENTIAL COSMECEUTICAL INGREDIENTS: IN VITRO AND CLINICAL STUDIES
Authors: Junlatat Jintana , Thorajake Piyaporn , Sripanidkulchai Bungorn , Tabboon Peera , Areemit Jringjai , Tuntiyasawasdikul Sarunya
Published: January 2025

The present study aimed to investigate the potential of three varieties of Thai pigmented rice, Dam-Mong (DM), Ma-led-Fai (MF), and Tubtim Chumphae (TC), as ingredients in cosmeceutical products because of their anti-inflammatory, anti-aging, and anti-melanogenic properties. The cyanidin-3-O-glucoside and peonidin-3-glucoside anthocyanins in the 50% ethanolic rice extract were found to be between 16.02 and 16.24 mg/g and 1.83 and 2.24 mg/g, respectively. The three extracts exhibited low cytotoxicity toward dermal cells, with half-inhibitory concentrations (IC50) greater than 2,000 µg/mL. All rice extracts suppressed the production of Prostaglandin E2 (PGE2) and decreased the levels of TGF-β1, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and CD40 in fibroblasts, suggesting the potential efficacy of the rice extract in exerting anti-inflammatory effects. Pretreatment with the MF extract significantly reduced matrix metallopeptidase-1 (MMP-1) levels and enhanced the production of procollagen (type I) genes in a dose-dependent manner, thereby inhibiting skin aging. Moreover, RT-PCR revealed that MF extract decreased tyrosinase enzyme activity and suppressed the production of tyrosinase-related protein-1 (TRP-1) and TRP-2, indicating its significant whitening properties. Facial serum containing the MF extract was subsequently prepared and applied to the faces of 20 women. The product markedly enhanced skin hydration, pigmentation, and elasticity, while diminishing wrinkles in the eye and cheek regions after four weeks of application. Moreover, the physical appearance of the serum did not changed after six months of storage and was recommended for storage at low temperatures. This suggests that MF extract has the potential to be used as a key ingredient in skincare products designed to improve the appearance and well-being of the skin.
POTENTIAL VOLCANIC TSUNAMI GENERATION IN THE SAWU SEA DUE TO THE MOUNT IYA LANDSLIDE
Authors: Sakka  , Amiruddin  , Hamzah Muh. Alimuddin , Saaduddin
Published: January 2025

This study investigates tsunami potential in the Sawu Sea caused by landslides triggered by Mount Iya activity in East Nusa Tenggara, Indonesia. Located near three densely populated islands—Ende, Timor, and Sumba—Mount Iya poses significant risks due to its history of volcanic activity, including a 1969 explosion that may have destabilized its southern edifice. This research employed two modelling approaches to analyze tsunami generation and propagation. Using the Fluidity and the Navier-Stokes equation, the study simulated tsunami generation during the initial interaction of landslide material with seawater. Results showed that the first wave could reach a height of 20 meters within 45 seconds and rise to 50 meters at 60 seconds. The COMCOT model, which applies the shallow water equation, modeled wave propagation in nearby areas. The tsunami wave heights diminished as they traveled outward. At Ts-1 (Ende Island), the maximum recorded height was 1.190 meters, with an arrival time of 187 seconds. At Ts-2 (Sumba Island), the first wave height was 0.018 meters, arriving after 25 minutes. Ts-3 (Sawu Island) recorded 0.129 meters within 22 minutes, while Ts-4 (Kupang City) noted 0.029 meters at 34 minutes. The results indicate that the impact of a tsunami diminishes with distance, posing minimal risks to distant islands. However, this study emphasizes the need for risk mitigation in vulnerable areas near the source. The tool provides vital insights into tsunami dynamics, including wave heights, arrival times, and exposure analyses, and supports local governments’ disaster preparedness.
A DUAL CLUSTER-HEAD ENERGY EFFICIENT ROUTING PROTOCOL USING REINFORCEMENT LEARNING FOR WSN
Authors: Kim Hye Yun
Published: January 2025

WSNs are distributed in a region with multiple nodes to collect information and notify users in order to achieve purposes such as environmental monitoring, event detection, disaster management, and wild animal tracking. However, since the batteries that operate the sensor nodes are difficult to replace or recharge, it is essential to extend the overall network lifetime by reducing energy consumption as much as possible after installation in the field. In this paper, we propose an energy-efficient and QoS aware routing protocol with dual cluster heads. In this method, reinforcement learning is used to select cluster heads. PCH (Primary Cluster Head) performs the function of receiving data from nodes in the cluster and transmitting it to BS, and SCH (Secondary Cluster Head) not only acts as a substitute for PCH, but also quickly transmits this information to users in case of an emergency. From the simulation results, we find that the proposed dual CHs using RL (Reinforcement Learning) protocol reduces the total energy consumption of node by approximately 16%. In addition, under the same conditions, the network lifetime increased by approximately 21% as the number of nodes in the cluster increased. In addition, when it was assumed that the occurrence of abnormal events was 5% of the total data occurrence, it was found that packets with transmission priority had a transmission delay that was approximately 26% faster than the Q-LEACH algorithm.
USER INVOLVEMENT IN SOFTWARE DEVELOPMENT: FACTORS, CHALLENGES, AND RECOMMENDATIONS
Authors: Abd-Allah Sohieb M. , AbdelGaber Sayed , Shaaban Essam
Published: January 2025

This research investigates various aspects of software enhancement and development, emphasizing the technological and social factors that influence consumer engagement throughout the Software Development Life Cycle (SDLC). As software transitions from a professional tool to a daily-life necessity, comprehending the interrelationship between organizational, social, and individual factors in software planning becomes increasingly crucial. Previous studies have demonstrated that non-technological variables play a significant role in project failure. The methodology employed in this research utilizes a survey instrument to collect data and information on the factors influencing user engagement throughout the six stages of the software enhancement lifecycle. The study categorizes these factors into individual and organizational dimensions and examines their impact on consumer engagement and software quality. The findings indicate that active consumer engagement enhances software effectiveness and reduces the likelihood of project failure. Through data analysis, the results demonstrate that ensuring user engagement is a sequential process throughout the SDLC, with each stage serving as an entry point for subsequent stages. The study elucidates the importance of stakeholder collaboration and engagement and the necessity to adopt adaptive approaches that consider consumers' diverse perspectives and opinions. By incorporating consumer feedback and insights into the early stages of improvement, organizations can enhance software outcomes and ensure alignment with consumer requirements. This research is novel in its introduction of a new dimension, demonstrating that user involvement in the technical stages of software development, whether as a product or service, can have a lasting impact after project delivery and throughout its lifespan, ensuring software continuity of use. This study contributes to a deeper understanding of the social and technological dynamics in software development and advocates a holistic approach that places significant emphasis on consumer participation.
STUDENTS WITH DYS DISABILITIES: WHAT IS THE MOROCCAN INCLUSIVE TEACHER PROFILE?
Authors: Mouaheb Houda , Slassi-Sennou Siham , Beqqali Nabila , Bayali Batoul , Essedaoui Aafaf , Radid Mohamed
Published: January 2025

Since 1998, the Moroccan Ministry of Education has been endeavoring to promote the education of children with disabilities through circulars and directives to ensure their access to education. Subsequently, the inclusive school project began to gain traction, and various guides for school directors, teachers, and regional directors were developed. However, the absence of this subject from the content of initial teacher training has prompted our investigation into the extent to which teachers are informed, particularly about learning disabilities, specifically DYS disabilities. A quantitative approach utilizing a questionnaire enabled us to assess teachers' level of knowledge and their interaction with students with these disabilities. The results highlight a significant discrepancy between the concept of inclusive education and the reality observed in the field in terms of the profile of the Moroccan inclusive teacher.
Relationship Between Organic Farmland Expansion and Greenhouse Gas Emissions in Europe in Implementing the Sustainable Development Goals
Authors: Kozlovskyi Serhii , Zayukov Ivan , Kozlovskyi Volodymyr , Tregubov Oleksandr , Storchak Sviatoslav , Mishchenko Viktor , Lavrov Ruslan
Published: January 2025

The global community is endeavouring to achieve the ambitious Sustainable Development Goals. An important area of implementation of all the seventeen goals is the introduction of organic production in agriculture. This will contribute to providing the population with food; improving public health; overcoming the problems related to hunger, poverty, poor health, limited clean drinking water, energy shortages, depletion of natural resources, climate change, and pollution of both aquatic and terrestrial ecosystems. The EU-27 countries need to reduce greenhouse gas emissions to zero by 2050, which exacerbates the issue. For this reason, the paper hypothesizes that organic farmland expansion will potentially result in an increase in greenhouse gas emissions. Accordingly, the purpose of the paper is to conduct empirical research into the impact of organic farmland expansion on the increase in greenhouse gas emissions in the EU. The correlation and regression analysis based on the use of available Eurostat statistics for the period 2014-2021 for selected individual European countries demonstrated that the majority of European countries exhibit a high degree of correlation.  According to data from all EU Member States (27), the relationship is strong and directly proportional. It was found that with an increase in the area of organic farmland by 1% in the EU27, greenhouse gas emissions will increase by 0.00000025 thousand tons. The calculations revealed that ceteris paribus, greenhouse gas emissions are influenced by the expansion of organic farmland by 62.4%. Among the European countries under study, similar trends are observed in Denmark, Germany, Estonia, Spain, the Netherlands, Portugal, Romania, Finland, Switzerland, and the United Kingdom. Meanwhile, in Lithuania and the Netherlands, the relationship is inversely proportional. Weak correlation, as evidenced by the calculated correlation coefficient, is observed in such European countries as Bulgaria (0.05); Poland (0.02); Slovakia (0.05). To implement the Sustainable Development Goals, it is recommended to take measures to change the culture of food consumption; to use agricultural technologies, methods, equipment, machinery and mechanisms more efficiently; and to rationally use the waste.
Pengaruh Pajak dan Belanja Modal Terhadap Pertumbuhan Ekonomi (Data Panel di Provinsi Kalimantan Timur)
Authors: Auliandhana Maisya , Amri Khairul
Published: January 2025

This study aims to see the effect of tax revenue and capital expenditure on economic growth in East Kalimantan. The data used is panel data of 8 districts and cities in East Kalimantan during the period 2013 to 2020. The data analysis equipment used is fixed-effect method panel regression, then continued with panel vector autoregression (PVAR) analysis. The results found that economic growth in a particular period was significantly influenced by economic growth in the previous period. Capital expenditure in a particular period is also significantly influenced by capital expenditure in the previous period. Taxes do not have a two-way causality relationship with economic growth and capital expenditure does not have a two-way causality relationship with economic growth. However, there is a one-way causality relationship between taxes and capital expenditure.
Analisis Determinan Perilaku Donasi Masyarakat pada Lembaga Filantropi Islam di Kota Banda Aceh
Authors: Hidayatullah Syarif , Furqani Hafas , Zulhilmi Muhammad
Published: January 2025

Philanthropic organizations play a vital role in Indonesia by providing assistance to those in need, including the poor, dhuafa, and disaster victims. However, in 2022, one Islamic philanthropic organization in Indonesia was involved in a case of fund misappropriation, raising concerns about potential ripple effects on other institutions. This study examines the influence of credibility, brand awareness, and financial literacy on public interest in donating to philanthropic institutions in Banda Aceh. Using a quantitative approach, this research employs linear regression analysis as the primary analytical tool. A total of 100 respondents were selected as samples, determined through Cochran's formula and a nonprobability sampling method. The findings indicate that credibility, brand awareness, and financial literacy positively impact the public's interest in donating to Islamic philanthropic institutions in Banda Aceh. Collectively, these factors significantly influence the intention to donate among residents of Banda Aceh.
Calculation of Actuarial Values Using The Result of The 2019 Makeham Mortality Law Contruction and The Cox Ingersoll Ros
Authors: M Suriani , Nisardi Muhammad Rifki , Nursamsi Nursamsi , Hukmah Hukmah , Sulma Sulma
Published: January 2025

Premium is an amount of money that must be paid by the customer at a certain time based on the insurance policy. This study aims to determine the value of whole life insurance premiums using the Makeham mortality law method and the Cox Ingersoll Ross (CIR) model. The result of the study obtained the calculation of interest rates using the CIR model, the smaller the  value, the greater discount and the premium paid using the Makeham mortality law method was Rp. 102.478 < premium <  Rp. 1.270.630 / Mounth.
The Effect of Reflective Learning Models with Realistic Mathematical Approaches with Keasyariahan Nuances on Mathematics Learning Outcomes
Authors: Nuari Yuyun Rima , Assaibin Muhammad , Febryanti Febryanti
Published: January 2025

This study aims to determine the effect of the reflective learning model with a realistic mathematical approach with religious nuances on the mathematics learning outcomes of Integral material students. The population in this study were all students of class XI IPS SMA Negeri 3 Polewali where the sample was taken by simple random sampling and taken by class XI IPS 4 as the experimental class and class XI IPS 1 as the control class. The instrument in this study was a learning achievement test consisting of pre-test and post-test and observation sheets consisting of student activity observation sheets and learning implementation sheets. The data obtained were analyzed using descriptive analysis and inferential analysis. The results of the descriptive analysis of mathematics learning outcomes in this case the post-test in both classes obtained an average value of 82.97 for the experimental class and 67.72 for the control class. The results of inferential analysis using the normality test and homogeneity test for both classes, namely the two classes are normally distributed and have homogeneous variance. From the results of descriptive analysis and inferential analysis, it can be concluded that the reflective learning model with a realistic mathematical approach with religious nuances has an effect on the mathematics learning outcomes of class XI social studies students at SMA Negeri 3 Polewali.
Inclusión y perspectivas pedagógicas en el ámbito social
Authors: Sánchez Ronco Alejandro
Published: January 2025

La educación es un derecho humano fundamental reconocido en múltiples tratados internacionales; sin embargo, garantizar el acceso a ella no es suficiente para asegurar que todas personas tengan las mismas oportunidades de desarrollo. En este contexto, surge la inclusión educativa, un enfoque pedagógico que propone el acceso equitativo y justo a la educación de todas las personas, independientemente de sus diferencias físicas, cognitivas, sociales o culturales.

La inclusión no sólo aborda las barreras al aprendizaje, sino que busca transformar el sistema educativo para que responda a las necesidades cada individuo, promoviendo la equidad y el respeto a la diversidad. Uno de sus principios clave es que la diversidad no es un obstáculo, sino una fortaleza. Este enfoque reconoce la singularidad de cada estudiante y, por tanto, el sistema educativo ha de ser lo suficientemente flexible para adaptar las metodologías de aprendizaje, los recursos y la evaluación. Para que la inclusión sea efectiva, las instituciones educativas deben ofrecer los apoyos y adaptaciones necesarios, utilizando tanto las tecnologías de asistencia como las adaptaciones curriculares. Esta personalización no sólo beneficia a los estudiantes con necesidades educativas especiales, sino que enriquece el ambiente de aprendizaje de todo el alumnado.

Uno de los mayores aportes de la inclusión educativa es la equidad. Esto no implica tratar a todos/as de la misma manera, sino de proporcionar a cada persona lo que necesita para tener éxito. En este sentido, la inclusión educativa se alinea con los principios de la justicia social, cuyo objetivo es eliminar las barreras estructurales que perpetúan la desigualdad. Asegurar que todos los estudiantes, independientemente de sus diferencias, accedan a una educación de calidad es un paso esencial para crear una sociedad justa y equitativa. Además, la inclusión educativa es una herramienta poderosa para la construcción de una ciudadanía más democrática y participativa. El alumnado que aprende en entornos inclusivos desarrolla habilidades sociales y emocionales fundamentales, como la empatía, la tolerancia y el trabajo en equipo, cualidades esenciales para vivir en una sociedad pluralista y para
РИЗИКИ Й ЗАГРОЗИ ПРОДОВОЛЬЧІЙ БЕЗПЕЦІ УКРАЇНИ ТА СТІЙКОСТІ ФУНКЦІОНУВАННЯ АГРОПРОМИСЛОВИХ РИНКІВ У ВОЄННИЙ І ПОВОЄННИЙ ПЕРІОДИ
Authors: Нікішина Оксана , Чеботарьова Наталія
Published: January 2025

У статті визначено основні виклики й загрози продовольчій безпеці України, акцентовано увагу на посиленні впливу безпекових ризиків на розвиток товарних ринків у воєнно-повоєнній економіці. Ідентифіковано головні загрози стійкості функціонування агропромислових ринків України, що виникли в мирний і воєнний час. Проведено експертну оцінку впливу загроз на стан агропромислових ринків у воєнний час і перші роки повоєнного відновлення. Акцентовано увагу на необхідності вдосконалення діючих методичних рекомендацій до моніторингу продовольчої безпеки з урахуванням нових викликів і найкращих міжнародних практик, що базуються на концепції стійкості (резильєнтності). Обґрунтовано доцільність розрахунку індикатора продовольчої безпеки за методикою ФАО та визначено його динаміку в мирний і воєнний час. Досліджено структурні трансформації ринків та зміну їх параметрів, зокрема, в сфері зовнішньої торгівлі. Систематизовано головні тенденції функціонування стратегічних агропромислових ринків України в воєнний час. Встановлено вплив безпекових загроз на стійкість функціонування агропромислових ринків за такими напрямами: структура, виробництво, ціна, зовнішня торгівля, конкурентоспроможність. Обґрунтовано систему регуляторних заходів та інструментів забезпечення стійкості функціонування ринків у контексті реалізації завдань національної програми 8 «Розвиток секторів економіки з доданою вартістю» Плану відновлення України. Прикладне значення отриманих результатів дослідження полягає в тому, що вони формують аналітичне та наукове підґрунтя для розробки програмних і стратегічних документів для розбудови стійких агропромислових ринків, а також превентивно-адаптивних заходів реагування на реальні й потенційні ризики у воєнний і повоєнний періоди.
Enhancing Signal Processing Efficiency in Software-Defined Radio Using Distributed Arithmetic and Look-Up Table-Based FIR Filters
Authors: Krishnan S. Hari , Sadiq Vali Syed
Published: January 2025

To meet the requirements of the wireless communication industry, digital communication systems require increasingly advanced coding and modulation technologies. Software-Defined Radio enables these advanced ideas to be easily adopted by such systems. The Finite Impulse Response filter is frequently used in wireless communication to pre-process detected signals to reduce noise by utilizing delay elements, multipliers, and adders. Traditional multiplier-based finite impulse response filter designs result in hardwareintensive multipliers that use a lot of space and energy and pose poor calculation speeds and low performance in throughput and latency. To overcome the existing issues, a novel Distributed Arithmetic with a Look Up Table-based FIR filter is proposed, which reduces the Bit Error Rate and latency and improves throughput by optimizing the channel equalizer as a crucial part of Software Defined Radio applications. Further, a key feature named the decimation factor is incorporated to dynamically alter the filter's output frequency response without altering the filter coefficients. Moreover, the worst-case critical route latency of partial product accumulation is reduced using a highly adaptable Parallel Prefix Adder. Additionally, the finite impulse response filters are integrated to decrease the number of Look-Up Tables, thereby saving time and memory. It also investigates the filter efficiency using faster multipliers and adders and validates it on an Artix-7 FPGA. As a result, the proposed model improved the filter’s performance over the other existing designs by achieving an operating speed of 260 MHz, delay of 190 ps, power dissipation of 1 m mW and throughput of 938.12 Mbps with the number of Look-Up Tables being 16504.
Towards Automated Musical Anamnesis for Music-based Intervention in Dementia Patients
Authors: Simmank Fabian , Grebosz-Haring Katarzyna , Ballhausen Thomas , Thomay Christian , Biallas Martin , Tauber Markus
Published: January 2025

Dementia is a neurodegenerative disease affecting millions worldwide, leading to cognitive decline and difficulties in daily activities. Music-based interventions offer a promising, cost-effective, non-pharmacological approach to improving quality of life for people with dementia. However, understanding both preferred and familiar music, as well as individual music affinity, is crucial to avoid overstimulation and ensure meaningful engagement. Developing a protocol for musical anamnesis, which gathers a patient’s musical history and hearing health, demands significant manual effort and expertise, limiting its scalability. An automated approach could enhance the sustainability of music-based therapy by reducing therapist time while maintaining relevance and preference evaluation. Here, we introduce Automated Musical Anamnesis (AMA), a personalized, scalable intervention combining interdisciplinary methods to support people with dementia.
Navigating the Uncertainties: A Study of the Challenges Women Offenders Experience Post Prison Release
Authors: Gungea Meera
Published: January 2025

Life in prison offers a different environment where one’s habits are transformed towards integration into prison culture, pushing aside the community culture outside prison walls. Upon release, an ex-offender's status often rooted in their criminal record faces jeopardized perception by common people. This perception deepens and solidifies when those ex-offenders try to reintegrate the society with a shortage of savings, limited ability to produce income, few social supports, and an overall lack of life skills to face these challenges. Their new social identity can face significant discrimination and social deprivation affecting successful community reintegration. We discuss the concept of the well-being of ex-detainees, where emotional well-being is believed to lead to resilience and better integration in society. An individual is connected to society through the relationships they have with others and, social capital refers to the natural or possible resources that result from membership in a supporting group that shares collective capital. Having a connection to others facilitates the internalization of societal norms and constrains the extent to which the individual deviates from societal norms. Research supports these theories in concluding that such connections may exert a protective influence, in particular, against offending behaviour and drug abuse, and that social capital is related to less crime in neighbourhoods and resilience to crime. This research explores the challenges females experience when integrating the society and studies the risk and protective which in turn may influence their resilience and successful integration. We are particularly interested in the female ex-detainees as the increasing number of female offenders across the island urges the need to unveil the factors that influence the social integration of female offenders in Mauritian society.
The Historical Phases of National Socialist Racial Theory
Authors: Gómez-Jeria Juan Sebastián
Published: January 2025

During the period between 1933 and 1945 the racial theory of National Socialism underwent enormous variations. It is possible to observe four different phases, some of which overlap in time. The first of these is based on the existence of a superior 'Aryan' race and defined by Hitler in Mein Kampf. This second stage, which ended around 1934, was characterized by the uncritical acceptance of Hans Günther's theses. Günther idea is centered on the Nordic breed: a tall, long-legged, thin, with average height, among males, about 1.74 m. Hair color is blonde. The stream of thought emanating from Hans Günther is known as Nordicism. The fact that about 95% of the German population, as well as almost the entire top leadership of the NSDAP, qualified as 'bastards-à-la-Günther', the Party was unable to accept such a conclusion. This was the generator of the third stage of NS racial theory. This phase is defined by an entire rejection of Günther's Nordicism. In Nuremberg, on the Day of the Party of 1933, Hitler declared: 'We do not conclude from the physical type of a man his ability, but from his achievements his race’. The fourth stage of the NS racial theory is fully demonstrated when the Waffen SS begins to welcome non-Nordic elements into its ranks. Since this fourth stage of National Socialist Racial Theory was interrupted in 1945, it is very difficult to predict what its end would have been.
Assessment of in Vivo Anti-Ulcer, Gastroprotective Activities, Acute Toxicity and UPLC-ESI-QToF-MS/MS Prediction of Annickia affinis (Exell) Versteegh & Sosef (Annonaceae) Stem Bark
Authors: Teinkela Jean Emmanuel Mbosso , Bamal Hans Denis , Fannang Simone Véronique , Happi Dorice Yolande Hagam , Loe Gisèle Marie Marguerite Etame
Published: January 2025

Annickia affinis is a medicinal plant traditionally used in Africa against several diseases including peptic ulcers. We conducted this study to evaluate the antiulcer and gastroprotective activities of the ethanolic extract of the stem bark of this plant. The antiulcer activity was evaluated on Wistar rats using 95% ethanol and then administering to them as treatment solutions, the ethanolic extract of the stem bark of the plant and other referenced anti-ulcer drugs over periods of 7 and 14 days. The gastroprotective activity was carried out following the opposite path, the different batches of rats first received one of the treating solutions and an hour later, the ulcer was induced on them and they were finally sacrificed an hour after administring the ulcerogenic solution for the macroscopic and microscopic analysis of their stomachs. Phytochemical screening revealed the presence of alkaloids, saponins, reducing sugars, coumarins, anthocyanins, anthraquinones. UPLC-MS analysis revealed the presence of 16 compounds, notably berberine, berberrubine, canadine, palmatine, jatrorrhizine, columbamine, pseudocolumbamine, 7,8-dihydro-8-hydroxypalmatine, atherosperminine, argentinine, 7-hydroxydehydronuciferine, 7-hydroxydehydronornucierine, Caryophyllene oxide, 1,5-epoxysalvial-4(14)-ene, humulene epoxide II and spathalenol. The administration of the ethanolic extract of the stem bark of Annickia affinis at doses of 2000 mg/kg and 5000 mg/kg showed no acute toxicity. The results obtained from the evaluation of pharmacological activities revealed that the ethanolic extract of the stem bark of Annickia affinis would have antiulcer and gastroprotective properties comparable to omeprazole and sucralfate at the dose of 150 mg/kg. It appears from this study that the stem bark Annickia affinis could be used both in the prevention and in the treatment of gastric ulcers which would justify its use in the traditional pharmacopoeia.
Surveillance of Aflatoxigenic Aspergilli and Aflatoxin Contamination in Edible Oils from Karachi: A Molecular and Quantitative Approach
Authors: Fatima Shaista , Yahya Saira , Siddiqui Adeena , Khadim Misbah
Published: January 2025

The presence of secondary metabolite, particularly aflatoxin produced by fungi, poses economic challenges in food and feed industries. This study aimed to identify aflatoxigenic Aspergillus species inedible oil and quantify total aflatoxins levels. We collected thirty sample of edible oil from various local market in Karachi and tested them for presence of Aspergillus flavus and total aflatoxin levels. Out of thirty, four samples tested positive for Aspergillus flavus using culture-based methods, which were subsequently confirmed by amplification of partial transcribed (ITS) region. Aflatoxin production was assessed using colorimetric methods, revealing that all A. flavus positive isolates (JB2, MGM4, LMM1, and RLM2) exhibited a plum red change upon exposure to ammonium hydroxide vapors on Sabouraud Dextrose Agar. Notably, JB2 also demonstrated color change on Yeast extract Sucrose and Coconut Agar medium, and exhibited blue fluorescence under UV light on coconut Agar medium. Aflatoxins were extracted from edible oil sample using solvent extraction method and quantified using a VICAM fluorometer. Among samples one exhibited total aflatoxin levels between 20-30ppb, five samples had levels below 20ppb, while 24 samples were negative for aflatoxin. These finding underscore the need of continued monitoring of aflatoxin contamination in edible oil.
PENGARUH KOMPLEKSITAS OPERASI PERUSAHAAN DAN KEPEMILIKAN PUBLIK TERHADAP AUDIT DELAY DENGAN UKURAN PERUSAHAAN SEBAGAI PEMODERASI
Authors: Ningsih Riyanti Ratna , Shanti Yunita Kurnia
Published: January 2025

This study aims to determine the effect of the complexity of company operations and public ownership on Audit Delay with company size as moderation. The population of this study uses Property and Real estate sector companies listed on the Stock Exchange in 2018-2022. This type of research is quantitative research with secondary data sources. Based on the purposive sampling method, a sample of 47 companies was obtained. The analysis method used is multiple linear regression analysis with data processing using the Eviews version 13 program. The results showed that the complexity of company operations and public ownership simultaneously had an effect on Audit Delay, while partially the complexity of company operations had no effect on Audit Delay, public ownership had a negative effect on Audit Delay, company size was unable to moderate the complexity of company operations on Audit Delay, and company size was able to moderate public ownership on Audit Delay
PENGARUH PERSEPSI KEMUDAHAN PENGGUNAAN, PERSEPSI KEGUNAAN, RISIKO DAN LITERASI KEUANGAN TERHADAP MINAT PENGGUNAAN QRIS PADA UMKM DI KABUPATEN BANYUMAS
Authors: Asfendi Afril Nanda , Alfizi Alfizi , Yuttama Faizal Rizky
Published: January 2025

This study aimed to evaluate the impact of perceived ease of use, perceived usefulness, risk, and financial literacy on the interest in using QRIS among MSMEs in Banyumas. Data were collected through online questionnaires, with 110 respondents participating. Multiple regression analysis, along with t-tests and F-tests, were employed, with a significance level set at <0.05. The study was based on the Theory of Acceptance Model, which explores technology acceptance, and the Theory of Planned Behavior, which examines reasoned action. The results indicate that perceived ease of use, perceived usefulness, and financial literacy positively and significantly influence interest in QRIS usage. Conversely, risk negatively and significantly affects this interest. Overall, the variables collectively have a positive and significant impact on QRIS usage interest, with an R square value of 54.5%.
A STUDY TO EVALUATE THE EFFECTIVENESS OF PLANNED TEACHING PROGRAMME ON KNOWLEDGE REGARDING DEEP VEIN THROMBOSIS AMONG B.SC. NURSING PART III STUDENTS AT SELECTED COLLEGES OF NURSING, KOTA (RAJ)
Authors: Latika Kashyap
Published: January 2025

Deep vein thrombosis (DVT) and pulmonary embolism (PE) collectively make up the condition known as venous thromboembolism (VTE). The incidence of VTE is 10% to 20% in general medical patients, 20% to 50% in patients who have had a stroke, and up to 80% in critically ill patients. The extent of the problem is underestimated, possibly because DVT and PE are often clinically silent. It is estimated that as many as 30% of patients hospitalized with VTE develop long-term post thrombotic complications. Hospital stays are shorter, which means that the majority of symptomatic thromboembolic complications in surgical patients occur after hospital discharge.
CONTRIBUIÇÃO DA POLÍTICA PÚBLICA PRONATEC NA EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA
Authors: Caldeira Daniela Machado , Faustino Teles Ricardo
Published: January 2025

Este estudo aborda a contribuição das políticas públicas na Educação Profissional e Tecnológica (EPT) e seus reflexos no mundo do trabalho, com o objetivo principal de traçar, por intermédio de narrativas de egressos, os reflexos dos cursos profissionalizantes no encaminhamento profissional de jovens e adultos de Alto Paraíso de Goiás. Dentro desta perspectiva, destacou-se como contexto histórico, a criação de políticas educacionais para trabalhadores após a crise capitalista de 1929 e concentra-se no Programa Nacional de Acesso ao Ensino Técnico e Emprego (PRONATEC) e seu impacto na EPT. O estudo se justificou pela relevância pública de compreender como as políticas em EPT, especificamente o PRONATEC, impactaram a formação profissional e as oportunidades de emprego dos egressos em Alto Paraíso de Goiás, possibilitando futuras políticas educacionais locais. Como trajeto metodológico, iniciou-se por uma revisão bibliográfica sobre o tema com uma abordagem qualitativa e natureza básica. Quanto aos procedimentos técnicos, foram combinados o estudo de caso e a pesquisa narrativa. A coleta de dados foi realizada por meio de entrevistas semi estruturadas e o tratamento dos dados foi por intermédio de análise das narrativas conforme Labov (1972) e Bardin (2001). Os resultados, em linhas gerais, revelaram a importância do PRONATEC na introdução de inovações, contribuindo para uma aprendizagem mais crítica dos egressos. Em síntese, a pesquisa ofereceu reflexões significativas sobre o papel das políticas públicas na EPT na formação profissional e nos mostrou como a educação profissional trouxe uma relevância representativa na vida dos indivíduos, que se sentiram representados e trouxe o resgate de suas vidas como cidadãos participativos, que trabalham, que estudam e que fomentam a economia local.
DEVELOPMENT OF A PLATFORM FOR REMOTE MANAGEMENT OF THE INTERNET OF THINGS INFRASTRUCTURE
Authors:   Federal State Budgetary Educational Institution of Higher Education “Grozny State Oil Technological University named after Academician M.D. Millionshchikov” Russia, Bisultanova Aminat A. , Magomed Ahmadov A. ,   Federal State Budgetary Educational Institution of Higher Education “Grozny State Oil Technological University named after Academician M.D. Millionshchikov” Russia, Baigiraev Ali B. ,   Federal State Budgetary Educational Institution of Higher Education “Grozny State Oil Technological University named after Academician M.D. Millionshchikov” Russia
Published: January 2025

The article discusses a platform for remote management (monitoring) of IoT devices, which have recently been very widely distributed around the world. At the same time, there is a problem of increasing the efficiency of designing information systems that will provide access to a variety of information from any corner of the world where there is access to the Internet. Therefore, an attentive and careful approach to choosing the architecture of the plat-form is important. An IoT platform is a set of components that provide: interaction with applica-tions, remote data collection from sensors, secure connection and device management. The IoT platform provides an advantage in creating IoT systems by providing development tools, which makes the Internet of Things easier and cheaper for end users. The functionality of the platform was analyzed. The main approaches to its construction are substantiated. The architecture of the platform is proposed, which allows user applications to interact with IoT devices. As a result, a working prototype of the IoT system was obtained, demonstrating the principle of operation of this platform. The system is based on a server that interacts with clients and IoT devices. How-ever, the interaction of the server with the devices is performed using an MQTT broker. Clients interact with the server using the WebSocket protocol. The server software is created using the Node programming language.js, TypeScript, and the LoopBack framework. The following tech-nology stack was used to create the client interface: CSS, HTML, Javascript, React, Material-UI. The developed platform is very flexible and allows you to: connect a variety of devices and con-figure devices through a browser; create scripts for managing the system as a whole (scripts are created using visual programming).
THE INFLUENCE OF ARTIFICIAL INTELLIGENCE ON THE INDIVIDUALIZATION OF THE EDUCATIONAL PROCESS
Authors:   Chechen State University named after A. A. Kadyrov, Grozny, Russian Federation, Lorsanova Zarina M. , Mantaev Khalid Z. ,   Chechen State Pedagogical University, Grozny, Russian Federation, Gochiyaeva Madina Dz. ,   North Caucasian State Academy, Cherkessk, Russian Federation
Published: January 2025

This article is devoted to issues related to the impact of artificial intelligence technologies on the personalization of the educational process. It is proved that such a direction as personalization throughout the entire development of the educational process is the most effective way to organize high-quality education for any student. The analysis of the current state of education and the use of artificial intelligence programs in the educational process is carried out. The main advantages and capabilities of artificial intelligence are presented, which it is possible to implement and actively use for students and teachers in order to organize high-qual-ity and effective training. The levels of personalization are highlighted. It is concluded that arti-ficial intelligence occupies one of the key places, and is the most promising direction, the im-provement of which contributes to the personalization of the educational process as a whole.
ECONOMICS AND MANAGEMENT OF ENTERPRISES AND INDUSTRIES THE ROLE OF HIPPOTHERAPY IN MEDICAL AND HEALTH TOURISM
Authors:   Northwestern Institute of Management of RANEPA, St. Petersburg, Russia, Kamenskikh Eduard A.
Published: January 2025

The article examines the role of hippotherapy in medical and health tourism and its potential to improve the physical and psycho-emotional state of tourists and patients with various diseases. The mechanisms of the health effects of horse riding, historical background, international experience of hippotherapy, as well as the conditions of this effective method in tourism products are analyzed. Data on the course of hippotherapy in the sports and health period aimed at rehabilitation, stress reduction and improving the quality of life are presented. Prospects for the development of hippotherapy programs, recommendations for organizing em-ployment, staffing and marketing promotion are offered.
SARS-CoV-2 and its long-term neurological impact: Unraveling the mechanisms of neurodegeneration and cognitive decline
Authors: M. Naffaa Moawiah
Published: January 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), is associated with neurological effects that persist beyond the acute phase, collectively referred to as post-acute sequelae of SARS-CoV-2 infection (PASC) or “long COVID.” This article discusses the neurological impacts of PASC, which can occur regardless of the initial illness’s severity. Studies indicate that most patients continue to experience symptoms for at least 3 months post-infection. Long-term effects include neurocognitive deficits, sleep disturbances, and the exacerbation of pre-existing conditions. Proposed mechanisms underlying these effects include neuroinflammation, microvascular damage, and autoimmune responses, while direct viral neuroinvasion remains a topic of ongoing debate. SARS-CoV-2 may also worsen pre-existing neurological disorders and increase the risk of developing neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease. The article highlights the need for longitudinal studies to better understand the variability in outcomes and the mechanisms driving these persistent effects. In addition, it explores the inflammatory pathways linking long COVID to AD. Both conditions are characterized by chronic inflammation, activation of shared markers such as the NLR family pyrin domain containing 3 inflammasome, and alterations in amyloid-beta production. The apolipoprotein E4 gene, a known risk factor for AD, is also associated with more severe COVID-19 outcomes. Neuroimaging studies reveal brain changes in COVID-19 survivors, particularly in regions related to cognition and memory, further emphasizing the need for long-term research to assess the potential role of long COVID in exacerbating neurodegenerative diseases.
Stroke risk among Nigerians with diabetes and hypertension: A pilot retrospective cohort study
Authors: Abbdullahi Abba Musa , Isah Usman Auwalu
Published: January 2025

Stroke is a leading cause of illness and death worldwide, often leaving survivors with severe disabilities. In sub-Saharan Africa, strokes remain prevalent among individuals with diabetes, hypertension (HTN), or both, significantly impacting the health, social stability, and economic well-being of families and communities. This study aimed to assess the risk of stroke development in Nigerian individuals diagnosed with both diabetes and HTN. The research included diabetic and hypertensive patients who attended the outpatient clinics at Imam Halliru and Imam Wali General Hospitals in Kano between January 2015 and August 2020. Patient data were manually extracted from hospital records. Regression and correlation analyses were conducted to compare the stroke risk between patients with either diabetes or HTN and those with both conditions. Among the 933 participants, 200 exhibited clinical features consistent with the World Health Organization definition of stroke. Of these, 85 (37.5%) had HTN, 67 (33.5%) had diabetes, and 58 (29%) had both conditions. Unemployment, female gender, advanced age, diabetes, and HTN were identified as factors associated with an increased stroke risk in the unadjusted analysis. The findings highlight a significantly higher stroke risk for Nigerians with both diabetes and HTN. Therefore, strict blood pressure control for hypertensive patients and rigorous blood sugar management for diabetic patients is critical.
CHATGPT NA LICENCIATURA EM MATEMÁTICA
Authors: Couto de Oliveira Gleisson , Vinholes Lopes Bruna , Denize Ott Felcher Carla
Published: January 2025

O objetivo deste artigo é investigar os motivos pelos quais acadêmicos do curso de Matemática utilizam ou não o ChatGPT em suas atividades educacionais. A pesquisa, de natureza qualitativa e quantitativa, foi realizada por meio de um questionário misto enviado via Google Forms a todos os acadêmicos do curso de Matemática, de uma Universidade Federal. Dos quarenta e oito acadêmicos matriculados, vinte e oito responderam ao questionário. Entre eles, dezoito relataram o uso do ChatGPT, enquanto dez afirmaram não utilizá-lo. Os resultados indicam que a maioria dos usuários recorre à ferramenta para resolver exercícios, compreender conteúdos, redigir textos, apoiar o processo criativo, entre outros. Aqueles que não fazem uso do ChatGPT apontaram dificuldades, a preferência por outras ferramentas, métodos de estudo tradicionais e a percepção de que a ferramenta é ineficiente em certas áreas da Matemática. Conclui-se que o ChatGPT pode potencializar a aprendizagem quando usado com um propósito claro de aprendizado.
Update on the diagnosis of severe asthma in children and adolescents
Authors: Vidal Alberto
Published: January 2025

Severe pediatric asthma is a very challenging type of asthma for both physicians and patients. Precision medicine in severe pediatric asthma has undergone important developments in recent years. This therapeutic approach requires an adequate diagnosis and clinical phenotyping of patients and is useful for predicting the prognosis and response to treatment in this type of patient. This article summarizes the scientific information of the last five years in the diagnosis of severe pediatric asthma, focusing on topics such as genetic markers, biomarkers, lung function, radiological techniques, and bronchoscopy.
What are biopharmaceuticals?
Authors: Pande Abhay H. , Prasad Yenisetti Rajendra , Anakha J.
Published: January 2025

Throughout history, biopharmaceuticals have been essential in addressing health crises and enhancing human well-being. With advancements in genetic engineering, biotechnology, and bioinformatics, the development and approval rates of new biopharmaceuticals have surged, placing them at the forefront of the pharmaceutical field. Modern manufacturing processes and streamlined regulatory pathways have further expedited approval timelines, providing hope for previously untreatable conditions and significantly improving patients’ quality of life worldwide. However, despite these advancements, ambiguity persists regarding the definition of biopharmaceuticals due to the use of varied terms and a lack of standardized definitions. This article addresses this confusion by proposing a clear and comprehensive definition of biopharmaceuticals. Additionally, we present a reclassification of biopharmaceuticals into seven distinct verticals based on their functions. We assert that biopharmaceuticals not only offer superior therapeutic benefits for human health but also contribute to environmental sustainability, promoting a healthier planet. Thus, this article aims to clarify the scope of biopharmaceuticals and advocate for their broader adoption in the pursuit of global health and environmental integrity.