bluuebunny/crossref_metadata_2025 huggingface dataset:
A Brief Discussion on the Countermeasures for the Cultivation of Administrative Management Professionals
Authors: Li Qi
Published: July 2020

With the social and economic development, the cultivation of professional talents in our country has made great progress, especially the administrative professional, has become a new kind of professional in recent years, the development is effective, but also suffered a series of problems, this article is from the perspective of the problem to carry out relevant exploration on the problems existing in the development in the current administrative management professional talent training, find the administrative countermeasures of talent cultivation.
Discussion on the Reform of Basic Computer Teaching of Non-Computer Majors in Colleges and Universities
Authors: Li Ting
Published: July 2020

The rapid development of information technology and the steady improvement of the national economy have promoted the increasing popularity of Internet hardware equipment. As a compulsory course for undergraduates, computer basic teaching is of great importance in the current social environment. In view of the current situation of basic computer teaching in non-computer majors in colleges and universities, this paper focuses on the research and discussion of the specific reform ideas of basic computer teaching, in order to provide scientific theoretical basis for the cultivation of compound computer talents.
A Preliminary Study on the Mixed Learning Mode of Public English in Higher Vocational Colleges under the Interactive English Platform
Authors: Liu Benying
Published: July 2020

In the past in the higher vocational education the entity class teaching mode is generally adopted in the process of public English teaching, in recent years due to the rapid development of Internet information technology and the emergence of multimedia teaching methods, to gradually change the traditional English teaching mode to entity class teaching and online mutual combination of Internet teaching. This new hybrid English teaching method has both the advantages of physical classroom teaching and the new advantages of online learning. It is a brand-new way of learning English. Interactive English platform is a new model of this new way of learning English. This paper will take this platform as an example and focus on the methods of learning public English in colleges and universities.
Innovation and Entrepreneurship Education and Teaching Based on “Internet+” Research and Exploratio
Authors: Pei Hongyan
Published: July 2020

In order to promote mass entrepreneurship and innovation, the General Office of the State Council issued the implementation opinions on deepening innovation and entrepreneurship education reform in institutions of higher learning. According to the guidelines for innovation and entrepreneurship proposed by the State Council, colleges and universities should combine the entrepreneurial needs of students and the innovative needs of the society, set up educational goals around the orientation of running a school, and carry out educational reform activities with innovation and entrepreneurship as the theme. Based on the overall social background of "Interne+" and distinct characteristics of the times, this paper analyzes the problems existing in innovation and entrepreneurship education in colleges and universities, and explores effective strategies for implementing innovation and entrepreneurship education in colleges and universities.
Study on the Role of Social Psychology in University Management
Authors: Sun Juan
Published: July 2020

The management of colleges and universities has an important influence on the development of colleges and universities. However, at the present stage, the management of colleges and universities in China attaches more importance to the system than to the humanities. Therefore, it is very important to integrate social psychology into the management of colleges and universities and analyze the social psychology of individuals and groups, so as to master the subjective thinking and psychological activities in management and add humanistic factors in management to realize the effectiveness of college management. This paper will try to make use of the contents of social psychology to analyze the problems and misunderstandings in the management of colleges and universities, in order to explore the role of social psychology in the management of colleges and universities, and explore the possibility of the practical application of social psychology in the management of colleges and universities.
Explore the Importance of Strengthening Folk Music Theory Learning in Music Lessons in Hohhot
Authors: He Zhang
Published: July 2020

At present our country's arts school is pushing new education plan, this made the related concept art education as well as major changes have taken place in the education mode. Also let the school music education realize the meaning of folk music is important, in the process of teaching reform, the local folk music also showed a more important role. In this paper, through the study of the characteristics and connotation of the folk music, we will sort out how to strengthen the learning and promotion of the folk music theory in the school music education in Hohhot. Based on the combination of music education and folk music, a more practical and complete music teaching method and system is constructed.
Progress in Alzheimer's Disease Research Based on SIRT1
Authors: Zhao Wenhui , Jin Qiu , Lin Bo , Zhu Xinshu
Published: July 2020

SIRT1 belongs to the family of Sirtuins deacetylase in mammals, which is mainly responsible for regulating the anti-infection, anti-apoptosis and anti-oxidative stress ability of cells. When organisms show degenerative changes in the nervous system, the expression level of SIRT1 will be up-regulated in order to play a protective role in the nervous system. In order to clarify the interaction between SIRT1 and Alzheimer's disease, this paper aims to provide scientific theoretical basis for the treatment of Alzheimer's disease by analyzing the regulation mechanism of SIRT1.
Research on Practical Teaching Reform of Electrical Engineering Specialty
Authors: Meng Mingchuan , Gao Jianyu
Published: July 2020

When the concept of quality education is continuously popularized and rooted in people’s minds, the practical teaching has undergone major reform. Electrical engineering is a subject with practical and professional spirit, In addition to teaching basic theoretical knowledge. In order to assist students with their application of theories to practice through practical operations, electrical engineering realizes the significance of optimizing and reforming teaching practice. This paper discusses the necessity of practical teaching reform and the construction of teaching system of electrical engineering specialty in colleges and universities, and discusses the path of practical teaching reform of electrical engineering specialty, so as to make advance to the development of electrical engineering major.
Study on the New Mode of Cultural Diversity Communication and Cooperation in "The Belt and Road Initiative" Construction
Authors: Peng Peilan , Fang Zewei
Published: July 2020

The implementation of "the Belt and Road Initiative" requires the development of the "five - connectivity" construction of policy coordination, facilities connectivity, unimpeded trade, financial integration, heart-to-heart communication. Among which, heart-to-heart communication is the premise. In addition, cultural transmission and cooperation is the foundation and guarantee for the construction of heart-to-heart communication contents and methods. What we need to do is to make clear the opportunities and challenges we are faced with and to make a far-reaching strategic deployment and adopt feasible measures and implementing approaches. Some domestic scholars do carry out some researches on the area of cultural communication and analyze some opportunities and challenges confronted. It lacks the analysis on the diversity of the means of cultural transmission and cooperation. The paper proposes an in-depth exploration and research on the implementing approaches and security measures, and it tries to construct a new integrated mode of cultural diversity communication and exchange, so as to promote the implementation of cultural transmission and cooperation to enhance the community of shared interests of "the Belt and Road Initiative".
Exploration on the Artistic Value and Realization Path of the Nationalization of Bel Canto Singing
Authors: Wang Jingtao
Published: July 2020

With the progress of the society, the international music culture is widely spread, and people's attention to the multicultural gradually increased, so that people love the music with the characteristics of the times, and their demand for different style of music is higher and higher. Since bel canto music was introduced into the Chinese music industry, it has been fully integrated into the folk music. In the process of integration, it just applies the correct scientific pronunciation to the traditional music sound system, making the folk music gradually mature. In particular, the mixed resonance singing method is applied to traditional music, and the translucency of sound and the extensibility of sound range are used to make the sound louder and more transparent, thus ensuring the richness of timbre. This paper mainly analyzes and explores the artistic value and realization path of bel canto's nationalization.
On the Management Measures of Construction Site
Authors: Wei Yingying
Published: July 2020

Construction project is a project involving many kinds of jobs and a large number of workers. The pros and cons of the construction project site construction management and the measures level directly influences the construction duration, cost and quality. This paper discusses the function of strengthening construction site construction management, the problems existing in construction site construction management and the measures to improve construction site construction management., with a view to providing some meaningful reference for our country's related research of construction project site construction management measures.
Research on Construction Safety and Technology of Civil Engineering in High-Rise Building
Authors: Zhang Lu
Published: July 2020

With the continuous development of the global economy, the construction technology is also increasingly mature, high-rise buildings are given a new meaning, which highly represents the economic strength of the country. Construction industry plays an important role in China. It is not only a pillar industry, but also an integral part of the national economy. The construction industry is based on civil engineering. At the same time, the safety of engineering and related technology are also important factors that determine the sustainable development of the construction industry. In this context, this paper attempts to analyze the safety problems and technologies in the construction of civil engineering high-rise buildings.
A Study on the Mode of Innovation and Entrepreneurship Training for College Business English Majors
Authors: Liu Xiaoxu
Published: July 2020

With the deepening of reform and opening up, China's economy has stepped into the fast track of high-speed development. In order to meet the needs of this situation, it is an inevitable trend for business English majors in colleges and universities to strengthen innovation and entrepreneurship learning. Training innovative and entrepreneurial talents for the society is also the need of higher education reform. Based on the social needs and the advantages of business English majors in colleges and universities, this paper explores the training mode of innovation and entrepreneurship talents suitable for economic development, and integrates business English education in colleges and universities into innovation and entrepreneurship education, so as to improve students' understanding of innovation and entrepreneurship education and further enhance their ability of innovation and development.
Talking about the Problems of Hierarchical Teaching in Higher Vocational English and Its Solutions
Authors: Shen Yajie
Published: July 2020

With the continuous deepening of education reform, the education department has put forward higher requirements for higher vocational education. Higher vocational colleges and universities can not only cultivate professional technical talents, but also cultivate applicable talents in many aspects. At present, the students come from different places with different education background in the colleges and universities. In the process of English teaching, teachers should implement stratified teaching to further improve the quality of English teaching. This paper discusses the problems and countermeasures of stratified teaching in higher vocational English, analyzes the problems existing , and proposes effective solutions.
Application and effect of project-based teaching in garden landscape design courses
Authors: Zhou Yan
Published: July 2020

In the course of garden landscape design, teachers can use the project-based teaching model to effectively guide students, help students improve their innovation ability and promote the development of students' comprehensive skills. This article explores the related teaching, its application and effectiveness in the course of garden landscape design, analyzes the practical effects of project-based teaching in garden landscape design and provides an important impetus for the development of this discipline.
O Protagonismo da Estrutura na Arquitetura do Edifício Vilanova Artigas - FAU-USP
Authors: Inojosa Leonardo , Roma Buzar Marcio Augusto , Silva Pasqua João Francisco
Published: July 2020

O projeto do edifício da Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo (FAU / USP) é de autoria do arquiteto Vilanovas Artigas, e recebe também seu nome. O projeto se destaca pela racionalidade construtiva, pela riqueza espacial e pelo aspecto didático com o qual os elementos construtivos são mostrados aos usuários do edifício, predominantemente estudantes de arquitetura. O projeto de 1961, foi executado entre 1966 a 1969. O concreto é usado em quase todo o edifício, fundações, vigas e pilares, e também no telhado e nas paredes. Destacam-se pilares externos que, posicionados fora da modulação estrutural, têm forma escultural, distinguindo-se dos demais pilares internos. Externamente, o edifício se apresenta como um volume retangular, suspenso no chão, sustentado pelos pilares esculturais, marcando as características do Brutalismo Paulista. Em contraste com a sobriedade e singularidade da forma externa, a espacialidade interna é muito dinâmica, resultado do jogo grandes balanços das lajes no vazio central, da alternância de aberturas e fechamentos e da generosidade dos espaços de circulação. Essa relação entre a arquitetura moderna e a concepção estrutural é explorada nesses estudos. O objetivo do presente trabalho é compreender os esforços a que a estrutura está sujeita por meio de ferramentas computacionais, como o software SAP 2000, verificar as justificativas construtivas, estéticas e didáticas da solução estrutural e destacar o protagonismo do sistema estrutural no resultado arquitetural.
Indicador de Vulnerabilidade para Gestão da Conservação de Edifícios de Valor Cultural
Authors: Orlandi Meira Ingrid , Zanoni Vanda Alice Garcia
Published: July 2020

Compreender a complexidade no acondicionamento de acervo museológico aliado às exigências físicas e funcionais do edifício é uma das dificuldades enfrentadas pelos gestores de museus. Este artigo apresenta um método de gestão de risco baseado em um Indicador de Vulnerabilidade (IVU) que representa de forma integrada os diversos fatores e valores que afetam a conservação do edifício de valor cultural e seu acervo museológico. A formulação do IVU foi baseada no Método Fatorial da ISO 15686-8 que considera sete variáveis: A-qualidade material, B-projeto arquitetônico, C-qualidade de execução da obra, D-características do ambiente interno, E-características do ambiente externo, F-condições de uso e G-nível de manutenção. Associado aos fatores que afetam a funcionalidade e o estado de conservação da edificação e seu acervo, foi desenvolvido o Índice de Valor Cultural (IVC) para valorar os aspectos culturais, relacionados à excepcionalidade, à imaterialidade e aos atributos que conferem significância ao patrimônio. Foi feita uma aplicação experimental do Método IVU no Museu Nacional do Conjunto Cultural da República, in Brasília-DF. Os resultados mostram que o método proposto é uma ferramenta capaz de avaliar individualmente um museu, mas também um conjunto de museus, identificando o potencial de risco inerente e a vulnerabilidade do edifício e seus acervos. Visualmente, o gráfico síntese da ferramenta foi capaz de representar os resultados nas distintas situações para a gestão de riscos de um conjunto de edifícios, para além de uma unidade isolada, de modo que o gestor possa avaliar de forma mais integrada os problemas existentes e monitorá-los ao longo do tempo.
Contribuições para a redução dos níveis de severidade dos acidentes nas vias de Brasília: riscos nas laterais das vias
Authors: Buson Márcio Albuquerque , Valentini Daniele
Published: July 2020

Esse trabalho pressupõe que uma parcela dos acidentes de trânsito ocorridos em Brasília poderia ter sido evitada ou ter significativa diminuição dos níveis de severidade caso as vias de Brasília realmente tivessem sido projetadas, construídas e mantidas conforme as normas e padrões de segurança no trânsito. O objetivo do estudo foi o de identificar e mapear os pontos de risco alto nas áreas adjacentes das principais vias do Plano Piloto de Brasília. Foram identificados, classificados e mapeados um total de 2058 (dois mil e cinquenta e oito) pontos de risco alto. A partir desse levantamento foi possível apresentar ações para a redução da acidentalidade e dos níveis de severidade dos acidentes nas vias de Brasília.
Associations between Perceived Racial Discrimination and Tobacco Cessation among Diverse Treatment Seekers
Authors: Webb Hooper Monica , Calixte-Civil Patricia , Verzijl Christina , Brandon Karen O. , Asfar Taghrid , Koru-Sengul Tulay , Antoni Michael H. , Lee David J. , Simmons Vani N. , Brandon Thomas H.
Published: July 2020

Objectives: This study investigated a) racial/ethnic differences in past-year discrimination experiences and b) associa­tions between discrimination and smoking abstinence.Design: Prospective, longitudinal analysis of smoking status. Perceived past-year discrimi­nation was assessed at baseline. ANCOVAs and intent-to-treat hierarchical logistic regressions were conducted.Setting: Dual-site (Tampa, FL and Miami, FL) randomized controlled trial testing the effects of a group cessation intervention plus pharmacotherapy.Participants: Treatment-seeking adult smokers (N=347; non-Hispanic White, non-Hispanic African American/Black, or Hispanic).Main Outcome Measures: Biochemically verified 7-day point prevalence abstinence (7-day ppa) was assessed immediately post-intervention and at 6-month follow-up.Results: After controlling for covari­ates, African Americans/Blacks reported greater perceived discrimination compared with non-Hispanic Whites (P=.02), and Hispanics (P=.06). Non-Hispanic Whites and Hispanics did not differ in perceived racial/ethnic discrimination experiences over the past year. Irrespective of race/ ethnicity, past-year perceived discrimina­tion was inversely associated with 7-day ppa, both post-intervention (AOR=.97, CI: .95-.99) and at 6-months (AOR=.98, CI: .96-.99). Among African Americans/Blacks, past-year perceived discrimination was inversely associated with 7-day ppa, both post-intervention (AOR=.95, CI: .92-.97) and at 6-months (AOR=.97, CI: .94-.99). Perceived discrimination was unrelated to 7-day ppa among Hispanics. Among non-Hispanic Whites, past-year perceived discrimination was inversely associated with post-intervention 7-day ppa (AOR=.95, CI: .91-.99), but not 6-months.Conclusions: Perceived racial/ethnic discrimination was greater among African American/Black smokers compared with non-Hispanic Whites. Perceived discrimina­tion was negatively associated with tobacco cessation in the full sample, and for African Americans at 6-months post-intervention. These data have implications for interven­tion delivery and health disparities.Ethn Dis. 2020;30(3):411-420; doi:10.18865/ed.30.3.411
Incorporating Health Equity and Community Perspectives During COVID-19: Commonalities with Cardiovascular Health Equity Research
Authors: Payton Foh Erica , Echeverria Sandra E.
Published: July 2020

The COVID-19 pandemic is revealing the deeply entrenched structural inequities in health that exist in the United States. We draw parallels between the COVID-19 pan­demic and our cardiovascular health equity research focused on physical activity and diabetes to highlight three common needs: 1) access to timely and disaggregated data; 2) how to integrate community-engaged approaches in telehealth; and 3) policy ini­tiatives that explicitly integrate health equity and social justice principles and action. We suggest that a similar sense of urgency regarding COVID-19 should be applied to slow the burgeoning costs and suffer­ing associated with cardiovascular disease overall and in marginalized communities specifically. We remain hopeful that the current crisis can serve as a guide for align­ing our principles as a just and democratic society with a health agenda that explicitly recognizes that social inequities in health for some impacts all members of society. Ethn Dis. 2020;30(3):421-424; doi:10.18865/ed.30.3.421
Tuzlu ve Sodik Arazilerde Islah ve Tarımsal Faaliyetler Sonrası Arazi Tahribatının Dengelenmesinin İzlenmesi
Authors: BUDAK Mesut , GÜNAL Hikmet , KILIÇ Orhan Mete , ACİR Nurullah
Published: July 2020

Tarım arazilerinin doğal veya insan kaynaklı etkiler ile bozulmasının önlenmesi ve tahrip olan arazilerin geri kazanımı son zamanlarda birçok ülkenin en önemli stratejik hedefleri arasına girmiştir. Bu kapsamda, arazi tahribatının dengelenmesi (ATD) kavramı, arazi bozulması oranının düşürülmesi ve bozulmuş alanların iyileştirilme oranının artırılmasının göstergesi olarak tanımlanmaktadır. Bir bölgede veya karasal ekosistemde verimli arazi alanı ve dolayısıyla sürdürülebilir arazi kullanımı sabit kaldığında veya arttığında ATD’ye ulaşıldığı düşünülebilir. Bu çalışmada, doğal olarak oluşmuş tuzlu/sodik özelliklere sahip merada, ıslah faaliyetleri ve sonrası başlatılan tarımsal üretimin etkileri, ATD çerçevesinde değerlendirilmiştir. ATD’nin değerlendirilmesinde, meranın ıslah sonrası tarımsal faaliyetler altındaki üretkenliği, ıslah öncesi ve ıslah sonrası dönemlere ait normalize edilmiş fark bitki örtüsü indeksi (NDVI), net birincil verimlilik (NPP) ile toprak organik karbon stoku (TOCS) verileri kullanılmıştır. Tüm alanda sulama imkânı bulunmadığından yaklaşık 1200 hektarlık alanda ıslah çalışması yürütülmüştür. Bu kapsamda 2008 ve 2012 yıllarında çalışma alanında 202 noktadan bozulmuş ve bozulmamış toprak örnekleri alınmıştır. Toprak örneklerinin organik madde (OM), hacim ağırlığı, toprak reaksiyonu (pH) ve elektriksel iletkenlikleri (EC) belirlenmiş ve değerlendirilmiştir. Islah kapsamındaki arazilerde başlangıçta ortalama 40.51 ton ha-1 olan TOCS, ıslah ve tarımsal faaliyetler sonrası 44.68 ton ha-1’a çıkmıştır. Islah öncesi -0.044 ile + 0.060 ve 125 ile 250 g C m-2 arasında olan NDVI ve NPP değerleri, ıslah sonrası önemli bir artış göstererek, 2013 ve 2017 yıllarında sırası ile 0.234-0.551 ve 0.419-0.631 ve 200-475 g C m-2 ve 200-407 g C m-2 aralığında kayıt edilmiştir. Islah çalışması yürütülen alanlarda ıslah öncesi ortalama OM değeri % 2.09 iken, ıslah sonrası ortalama % 2.16’ya çıkmıştır. EC değerleri ise 4.08 dS m-1’den 2.26 dS m-1’e düşmüştür. Elde edilen bulgular arazi ıslah çalışmalarında benimsenen arazi yönetim uygulamalarının arazi üretkenliğine dolayısı ile ATD'ye olumlu bir etki yaptığını ortaya koymaktadır. Aynı zamanda bu çalışma, arazi bozulması ve dengelenmesinin izlenmesi için güncel veri tabanlarının önemini de ortaya koymaktadır.
Farklı Besi Zamanlarındaki Ultrasonik Ölçümler ile Karkas Özellikleri Arasındaki İlişkilerin Belirlenmesi
Authors: ALTAY Yasin , KARABACAK Ali , AYTEKİN İbrahim
Published: July 2020

Bu çalışma, Akkaraman kuzularının farklı entansif besi sürelerinde ultrasonik ölçümler ile karkas özellikleri arasındaki ilişkileri çok değişkenli bir korelasyonla (kanonik) tahmin etmek amacıyla yapılmıştır. Bu amaçla yaklaşık 2.5 aylık yaşta ortalama 20 kg canlı ağırlıkta 16 adet erkek Akkaraman kuzuları besiye alınmış, 10 günlük alıştırma periyodu ve 70 günlük entansif besi sonunda kesime gönderilmiştir. Hayvanlara besi süresince 150 g kuru yonca otu ve ad-libitum olarak kesif yem verilmiştir. Besi başı, ortası ve sonundaki ultrasonik ölçümler olarak göz kası derinliği, göz kası üstü yağ kalınlığı ile deri kalınlığı bağımsız değişken veri seti olarak alınırken, karkas özellikleri ise bağımlı değişken veri seti olarak alınmıştır. Sonuç olarak Akkaraman kuzularının besi başında kanonik korelasyon katsayıları 0.999, 0.977 ve 0.549 iken; besi ortasında 0.980, 0.931 ve 0.770, besi sonunda ise 0.999, 0.996 ve 0.814 olarak belirlenmiştir. Besi başında ilk kanonik korelasyon katsayıları ve besi sonunda birinci ve ikinci kanonik korelasyon katsayıları istatistik olarak önemli iken (P<0.05), besi ortasındaki kanonik korelasyon katsayıları istatistik olarak önemli olmadıkları saptanmıştır. Sonuç olarak, Akkaraman kuzularının besi süresince alınan ultrasonik ölçümlerinin karkas özelliklerinin tahmininde kullanılabileceği tespit edilmiştir.
La prostitución: notas para el debate
Authors: Lora Pablo de
Published: July 2020

Estas notas tienen la única pretensión de mostrar qué argumentos pueden ser esgrimidos frente a la posibilidad de intercambiar sexo por dinero si asumimos una concepción desacralizada o no significativa del sexo de acuerdo con la cual el consentimiento de los intervinientes es condición necesaria y suficiente de la licitud moral y jurídica de la relación sexual. A lo largo de estas páginas se analizan los argumentos basados en alguna forma de perfeccionismo moral, la falta de consentimiento, el daño, la instrumentalización y el conocido como argumento expresivo.
Leer en tiempos de COVID-19
Authors: Goerlich Peset José María
Published: July 2020

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DIMENSI METRIK KETETANGGAAN LOKAL GRAF HASIL OPERASI k-COMB
Authors: Pratama Fryda Arum , Susilowati Liliek , Utoyo Moh. Imam
Published: July 2020

Research on the local adjacency metric dimension has not been found in all operations of the graph, one of them is comb product graph. The purpose of this research was to determine the local adjacency metric dimension of k-comb product graph and level  comb product graph between any connected graph G and H. In this research graph G and graph H such as cycle graph, complete graph, path graph, and star graph. K-comb product graph between any graph G and H denoted by GokH. While level k comb product graph between any graph G and H denoted by GokH.In this research, local adjacency metric dimension of GokSm graph only dependent to multiplication of the cardinality of V(G) and many of k value, while GokKm graph and GokCm graph is dependent to dominating number of G and multiplication of the cardinality of V(G), many of k value, and local adjacency metric dimension of Km graph or Cm graph. And then, local adjacency metric dimension of GokSm graph only dependent to the cardinality of V(Gok-1Sm), while GokKm graph and GokCm graph is dependent to dominating number of G and multiplication of the local adjacency metric dimension of Km graph or Cm graph with cardinality of V(Gok-1Km) or V(Gok-1Cm).
Flower Pollination Algorithm (FPA) to Solve Quadratic Assignment Problem (QAP)
Authors: Samdean Derby Prayogo , Suprajitno Herry , Winarko Edi
Published: July 2020

The purpose of this paper is to solve Quadratic Assignment Problem using Flower Pollination Algorithm. Quadratic Assignment Problem discuss about assignment of facilities to locations in order to minimize the total assignment costs where each facility assigns only to one location and each location is assigned by only one facility. Flower pollination Algorithm is an algorithm inspired by the process of flower pollination. There are two main steps in this algorithm, global pollination and local pollination controlled by switch probability. The program was created using Java programming language and implemented into three cases based on its size: small, medium and large. The computation process obtained the objective function value for each data using various values of parameter. According to the pattern of the computational result, it can be concluded that a high value of maximum iteration of the algorithm can help to gain better solution for this problem.
Analisis Kestabilan dan Kontrol Optimal Model Matematika Dinamika Pelanggan Berdasarkan Kebijakan Pemasaran
Authors: Farchan Muhammad Iqbal Abdi , Fatmawati Fatmawati , Alfiniyah Cicik
Published: July 2020

Customer dynamics include the exchange of information and ongoing transactions between customers and the organization. This process has an important role in the company to run its business, so that the number of customers increase. To achieve this, many things are done by the company. One of the strategies is product advertising by word of mouth. The purpose of this thesis is to analyze the stability of equilibrium point and to apply the optimal control word of mouth advertising on mathematics model of the customer dynamics based on marketing policy. Mathematics model of the customer dynamics based on marketing policy without control has two equilibrium points, namely non – endemic equilibrium (E0) and endemic equilibrium (E1). Local stability of equilibrium and the existence of endemic equilibrium depends on basic reproduction number (R0). The non – endemic equilibrium tend to asymptotically stable if R0 < 1.  The problem of optimal control is solved by Pontryagin’s Maximum Principle. The simulation results show that the total number of referral and regular customer populations that are given control in the form of word of mouth advertising efforts at the end of the observation are 312 and 18470 with the control effort costs occurred in 1798364.63. While the total number of referral and regular customer populations that are not given control in the form of word of mouth advertising efforts at the end observation are 241 and 17260. Based on these results show that word of mouth advertising efforts have an effect to increase the number of referral and regular customer in accordance with the aim of providing optimal control.
CLASSIFICAÇÃO DAS VARIAÇÕES MORFODINÂMICAS E PROCESSOS COSTEIROS, PRAIA DO PAIVA, PE, BRASIL
Authors: Holanda Tiago Fernando , Gonçalves Rodrigo Mikosz , Lino Anderson Pereira , Pereira Pedro Souza , Sousa Paulo Henrique Gomes de Oliveira
Published: July 2020

A zona costeira está relacionada a porção continental e oceanica, considerada como dinâmica e complexa, sofre alterações em diversas escalas temporais. As classificações morfodinâmicas das praias são fundamentais para o monitoramento dos ciclos sedimentares, identificando processos temporais de estabilidade, acreção e erosão. Os objetivos deste estudo são efetuar a classificação morfodinâmica e a identificação de alguns processos costeiros, considerando uma análise espaço temporal (2010, 2011 e 2012) na praia do Paiva, localizada no município do Cabo de Santo Agostinho, região metropolitana do Recife no estado de Pernambuco, Brasil. Para isso, foram utilizadas informações tridimensionais do modelo digital do terreno obtidas pelo sistema global de posicionamento por satélites, bem como dados hidrodinâmicos (clima de ondas). Como resultados foram identificadas a presença de bermas, cúspides e canais de correntes de retorno, além de três estágios morfodinâmicos durante diferentes datas, sendo eles: banco transversal e corrente de retorno; banco e praia rítmicos e terraço de baixa-mar. As ondas apresentaram direções E, ESE e SE com a altura significativa de ondas variando de 1,61 a 3,39 m tendo 9,3 s de período médio de onda. Os perfis temporais apresentaram variações significativas, demonstrando processos de acreção e erosão, que variaram em torno de 1 m (verticalmente) na zona de espraiamento. O cálculo do balanço sedimentar resultou em acreção nos períodos de primavera e verão e erosão do outono ao inverno. As feições mapeadas mostraram-se eficazes para a classificação morfodinâmica proposta, gerando subsídios importantes para o monitoramento costeiro.
ANÁLISE DA DINÂMICA PRAIAL APÓS A DEPOSIÇÃO DE LAMA EM 2014 NA PRAIA DO CASSINO (RS, BRASIL) UTILIZANDO AERONAVE REMOTAMENTE PILOTADA
Authors: De Oliveira Ulisses Rocha , Simões Rodrigo silva , Porto Fabricio Soares , Caminha Eduardo Seta , Calliari Lauro Júlio , Romeu Marco Antônio Rigola
Published: July 2020

Nos últimos anos a praia defrontante ao balneário Cassino, Rio Grande, RS, vem sendo palco de eventos de deposição de lama. O evento de deposição de lama na praia analisado neste trabalho iniciou em abril de 2014 e perdurou até o final de 2016. O objetivo do presente estudo foi avaliar as alterações na dinâmica da praia, associada a esse evento de deposição de lama, sobretudo as alterações decorrentes da ação das ondas, que possibilitaram uma regeneração da praia em 2016. Foram realizados 12 levantamentos aerofotogramétricos usando um drone DJI® Phantom 3 Professional entre junho de 2016 e novembro de 2017 na porção central do balneário Cassino. As fotografias oblíquas possibilitaram uma visão mais ampla da praia. Já as fotografias verticais cobriram um pequeno segmento de 368 m de linha de costa. Nesta porção foram digitalizados o limite praia duna frontal, a linha d´água e dunas formadas próxima a face da praia após a deposição de lama. Dados medidos por dois ondógrafos direcionais foram utilizados para caracterizar a ação das ondas entre maio e dezembro de 2016. As primeiras imagens adquiridas em maio de 2016 demonstram a praia com influência dos depósitos de lama fluída, tendo este depósito uma extensão de cerca de 7 km. Neste período, podemos destacar uma praia subaérea mais larga e a ausência da zona de surfe, com pequenas dunas sobre o pós-praia, próximas da face da praia, dado o longo período sem ondas no segmento, consideradas neste trabalho como dunas anômalas. Desde o início do monitoramento, observou-se que o avanço das ondas sobre o depósito de lama era evidente, visto que o mesmo não estava sendo reposto. Após a ação das ondas durante o ano de 2016 o banco de lama se deslocou sobre o pós-praia e as ondas passaram a atingir a costa novamente, passando sobre o bolsão de lama. A partir disso a energia das ondas passou a ser mais atuante na praia subaérea, regenerando a mesma. A fotografia de 29 de outubro demonstra uma praia praticamente recuperada do depósito de lama, com praia arenosa e larga zona de surfe. No trecho coberto por imagens verticais, houve redução progressiva na área das dunas anômalas, situadas sobre o pós-praia, desde 1705 m2 em maio de 2016, 1685 m² em junho, 654 m² em agosto e apenas 190 m2 em setembro. As fotografias obtidas em datas posteriores ao ciclone de 27 de outubro mostram que as dunas vegetadas formadas no pós-praia desapareceram na maior parte da praia. Em 2017, as imagens demonstram uma praia arenosa dominada por ondas, condição comumente identificada, demonstrando um processo de resiliência no local.
Samba novo e samba de morro: política e sonoridade em Opinião de Nara
Authors: Gerolamo Ismael De Oliveira
Published: July 2020

Partindo de apreciações e escutas da produção de Nara Leão durante a década de 1960 e mais detidamente de seu segundo disco, o presente trabalho busca lançar luz à efetivação de uma “primeira guinada” em sua trajetória, na pretensão de contribuir para delinear um esboço da personalidade musical da cantora. De formação bossa-novista, a intérprete tornou-se uma das figuras de referência da vertente engajada da canção brasileira em meados da referida década. Sua produção evidencia um duplo movimento efetuado por alguns cancionistas no período: um retorno a certas tradições da canção popular entendida enquanto fonte primordial a informar um projeto poético (e político) e a manutenção de procedimentos musicais entendidos como novos ou modernos (embora uma espécie de ruptura com a bossa nova, então sinônimo de modernidade, tenha sido até certo ponto efetuado).
Psychological stress enhances keloid development via stress hormone-induced abnormal cytokine profiles and inflammatory responses
Authors: Yang Ya-Ting , Wu Xiao-Li , Liu Wei
Published: July 2020

Keloid is a fibroproliferative disorder resulting from the abnormal wound healing process, and it causes both cosmetic concerns and functional disabilities. Genetic predisposition, wound trauma, foreign body reaction, mechanical stretch, and immune dysfunction are common risk factors, but there remain mechanisms unclarified, leaving challenges in addressing the clinical concerns of recurrence and resistance. However, similar patterns of growth and metabolism between keloids and cancers provide a unique insight into the future exploration of keloid pathogenesis. Psychological stress has been demonstrated to be involved in the development and drug resistance of multiple cancers, but this aspect remains less-explored in keloids. Clinical observations and published investigations have noticed that persistent stress is common among keloid patients and their symptoms tend to deteriorate under stressful conditions. Following a thorough review of the published literature, we have identified three signaling pathways that might imply how stress hormones are likely to influence the keloid pathogenesis via activating adrenergic receptors and dysregulating the immune system. Thus, we hypothesized that psychological stress would be a key risk factor for keloid development via stimulating fibrosis, aggravating local hypoxia, and inflammation.
The ATP Hypothesis: A New Conceptual Framework for the Origin of the Genetic Code
Authors: Xie Ping
Published: July 2020

More than half a century has passed since the discovery of the genetic code, but its origin is still one of the greatest mysteries in life science, although a plenty of theories have been proposed so far, as none can explain satisfactorily why the genetic code evolved in such a way, especially in the context of the biochemical system, a relation of part to whole. Here, a new hypothesis is proposed, according to which ATP is at the origin of the genetic code by its coevolution with the pristine biochemical system of the protocell. This hypothesis shows how primitive life with its genetic code emerged through a series of processes from energy flow to information communication mediated by ATP. First, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the extant biochemical systems. Second, ATP serves as not only an energy carrier but also an informatization molecule, as ATP could energetically elongate chains of both polynucleotides and polypeptides, thus providing a bridge between these molecules and eventually mediating biochemical innovation in the protocell from energy transformation to informatization, a process for creating and managing information. Informatization was inevitably coupled with structuralization (processes for organizing or incorporating cellular structures), cyclizing polynucleotides and polypeptides into a feedback loop of reciprocal causation. The triplet codon might be only for stereochemical handling of amino acids through, e.g., Watson–Crick pairing interactions. It is only the evolutionary completion of the genetic code from RNA to DNA that, contrary to the central dogma, marked the dawn of cellular life, when Darwinian evolution began to operate. The ATP hypothesis sheds light on the origin of life, together with the formation of both photosynthetic and biochemical systems, which remains largely unknown thus far.
A Flexible Genome-Scale SARS-CoV-2 Clone Resource
Authors: Kim Dae-Kyum , Knapp Jennifer J. , Kuang Da , Chawla Aditya , Cassonnet Patricia , Lee Hunsang , Sheykhkarimli Dayag , Samavarchi-Tehrani Payman , Abdouni Hala , Rayhan Ashyad , Pogoutse Oxana , Coyaud Etienne , van der Werf Sylvie , Demeret Caroline , Gingras Anne-Claude , Taipale Mikko , Raught Brian , Jacob Yves , Roth Frederick P.
Published: July 2020

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.
Assessing Global Frailty Scores: Development of a Global Burden of Disease-Frailty Index (GBD-FI)
Authors: O’Donovan Mark , Sezgin Duygu , Kabir Zubair , Liew Aaron , O’Caoimh Rónán
Published: July 2020

Frailty is an important age-associated risk-state. Despite this, many countries lack population estimates and large heterogeneity exists amongst studies. The Global Burden of Disease (GBD) study, provides comparable high-quality population-level data for 195 countries and territories. Frailty has never been measured in the GBD studies. This analysis applies the deficit accumulation model to construct a novel frailty index (FI) using the GBD 2017 dataset. Standard FI criteria were applied to all GBD categories such that selected items were health-related, age-correlated, sufficiently prevalent, did not saturate at an early age, had little redundancy/duplication, covered a range of systems, were plausible and were available serially for the same population. From all 554 GBD items, 36 were selected including 26 non-communicable diseases, 3 metabolic risks, 3 biological impairments, infectious diarrheal diseases, protein-energy malnutrition, injurious falls, and low physical activity. Variable face validity was displayed against a selection of established FIs. The mean GBD-FI score for the global population aged ≥70 years in 2017 was 0.16; scores were higher in females than males (0.16 vs 0.15, respectively). Deficits accumulated with age at an estimated rate of 0.026 per year. Adding the mean GBD-FI scores to a regression model including country-level variables for demographics (proportion ≥85 years, proportion female), healthcare quality (HAQ index), and development (SDI) increased the adjusted r2 value from 27.0% to 39.6% (p<0.001) for predicting country-level death rates from non-communicable diseases, suggesting that the GBD-FI is a useful predictor of mortality. Further analysis is required to compare the reliability and predictive validity of the GBD-FI with existing frailty tools
Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway
Authors: Nardi Monica , Baldelli Sara , Ciriolo Maria Rosa , Costanzo Paola , Procopio Antonio , Colica Carmela
Published: July 2020

Oleuropein, glycosylated secoiridoid present in olive leaves is known to be an important antioxidant phenolic compound. We studied the antioxidant effect of low doses of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by the H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions, H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggests that the growth arrest and cell death of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects the myogenesis of C2C12 cells; because MyoD mRNA levels and the differentiation process are restored with 3,4-DHPEA-EA(P) after treatment. Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process in a genomic and epigenomic manner by functioning as an efficient antioxidant.
Rapid Senectome and Alternative Splicing miRNAs Changes with the Relaxation Response: A One Year Follow-Up Study
Authors: Dal Lin Carlo , Marinova Mariela , Brugnolo Laura , Rubino Giorgio , Plebani Mario , Iliceto Sabino , Tona Francesco
Published: July 2020

Mental stress represents a pivotal factor in cardiovascular diseases. The mechanism by which stress produces its deleterious effects is still under study but one of the most explored pathway is cell senescence. In this scenario, circulating microRNAs appear to be mobile regulatory elements of the telomerase activity and alternative splicing within the ”senectome” network. Anti-stress techniques seem to be able to slow-down aging process. As we have recently verified how the practice of Relaxation Response (RR), counteracting psychological stress, determines favorable changes of some inflammatory genes expression, of some neurotransmitters, hormones, cytokines and inflammatory circulating microRNAs, we aimed to verify a possible change even in serum levels of 4 senectome micro-RNAs (SE-miRNAs -20, -30, -410, -515), testing the activity of telomerase in peripheral blood mononuclear cells-PBMCs. We analyzed also alternative splicing microRNAs 134 and 183. According to our data, miRNA-20 and -30 levels and PBMCs-telomerase activity increase during the RR while -410 and -515 levels decrease. Moreover, during the RR sessions both miRNA-134 and -183 decrease. The mediators considered in this work seem to vary rapidly according to a (stress)-relaxation condition showing that psychic activity should be part of the study of aging factors.
Formate Dehydrogenase (FDH1) Localizes to Both Mitochondria and Chloroplast to Play a Role in Host and Nonhost Disease Resistance
Authors: Lee Seonghee , Vemanna Ramu S. , Oh Sunhee , Rojas Clemencia M. , Oh Youngjae , Kaundal Amita , Kwon Taegun , Lee Hee-Kyung , Muthappa Senthil-Kumar , Mysore Kirankumar S.
Published: July 2020

Nonhost disease resistance is the most common type of plant defense mechanism against potential pathogens. In this study, the metabolic enzyme formate dehydrogenase (FDH1) was identified to be involved in nonhost disease resistance in Nicotiana benthamiana and Arabidopsis thaliana. In Arabidopsis, AtFDH1 was highly upregulated in response to both host and nonhost bacterial pathogens. Arabidopsis Atfdh1 mutants were compromised in nonhost resistance, basal resistance, and gene-for-gene resistance. The expression patterns of salicylic acid (SA) and jasmonic acid (JA) marker genes after pathogen infections in Atfdh1 mutant indicated that SA is most likely involved in the FDH1-mediated plant defense response to both host and nonhost bacterial pathogens. Previous studies reported that FDH1 localizes to only mitochondria, or both mitochondria and chloroplasts. Our results showed that the AtFDH1 localized to mitochondria and the amount of FDH1 localized to mitochondria increased upon infection with host or nonhost pathogens. Interestingly, the subcellular localization of FDH1 was observed in both mitochondria and chloroplasts after infection with a nonhost pathogen in Arabidopsis. We speculate that FDH1 plays a role in cellular signaling networks between mitochondria and chloroplasts to produce coordinated defense responses such as SA-induced reactive oxygen species (ROS) generation and hypersensitive response (HR)-induced cell death against nonhost bacterial pathogens.