bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of two types of casting in early-onset scoliosis
Authors: Tassone C , Thometz J , Escott B , Spellman C , Liu XC
Published: June 2021

Early-onset scoliosis (EOS) can be a progressive and debilitating condition if left untreated. Different casting techniques have fallen in and out of favor over the years for conservative management. Two types of casting, elongation-derotation-flexion (EDF) and body casting (BC) are employed at our institution. Here we compare the radiographic outcomes between these two types of casting in a cohort of patients diagnosed with EOS. Sixteen children with EOS were treated by EDF serial casting while seventeen children with the same diagnosis were treated by BC. Radiographic measurements included Cobb angle, rib-vertebral-angle difference (RVAD) and vertebral rotation (VR) by Nash-Moe method in casting (IC) or out of casting (OOC), thoracic height (TH) and width (TW). All of the patients had x-ray measurements at pre-casting OOC, 1st IC and final post-casting OOC. Casts were changed every 2–4 months. Independent two sample t-test, Wilcoxon rank-sum test, and Chi-square test were performed. There were no significant differences at the initial treatment for age, classification of EOS, OOC, RVAD, VR, kyphosis, TH, and TW between EDF and BC casting. There were no significant differences of changes for OOC, RVAD, VR, kyphosis, TH and TW from pre-casting to the final post-casting status between two casting techniques (P>0.05). However, children with EDF tended to receive 3 to 4 more castings than those with BC (7.5 vs.4 casts) (P=0.007) and achieved better outcomes in success (25% vs.20%) and improvement (50% vs.10%) (P=0.03). EDF has better outcomes with EOS improvement when there is treatment of longer duration.
The impact of immediate in-brace 3D corrections on curve evolution after two years of treatment: preliminary results
Authors: Guy A , Labelle H , Barchi S , Aubin CÉ
Published: June 2021

For the brace treatment of adolescent idiopathic scoliosis (AIS), in-brace correction and brace-wear compliance are well-documented parameters associated with a greater chance of treatment success. However, the number of studies on the impact of sagittal and transverse correction on curve evolution in the context of bracing is limited. The objective of this work was to evaluate how immediate inbrace correction in the three anatomical planes is related to long-term curve evolution after two years of bracing. We performed a retrospective analysis on 94 AIS patients followed for a minimum of two years. We analyzed correlations between in-brace correction and two-year out-of-brace evolution for Cobb and apical axial rotations (ARs) in the medial thoracic and thoraco-lumbar/lumbar regions (MT & TL/L). We also studied the association between the braces’ kyphosing and lordosing effect and the evolution of thoracic kyphosis (TK) and lumbar lordosis (LL) after two years. Finally, we separated the patients into three groups based on their curve progression results after two years (corrected, stable and progressed) and compared the 3D in-brace corrections and compliance for each group. Coefficients were statistically significant for all correlations. They were weak for Cobb angles (MT: -0.242; TL/L: -0.275), low for ARs (MT: -0.423; TL/L: -0.417) and moderate for sagittal curves (TK: 0.549; LL: 0.482). In-brace coronal correction was significantly higher in corrected vs stable patients (p=0.004) while compliance was significantly higher in stable vs progressed patients (p=0.026). This study highlights the importance of initial in-brace correction in all three planes for successful treatment outcomes.
Back muscle function in adolescent girls treated with a rigid brace for idiopathic scoliosis: no impact of 6-month brace wear on muscle strength or endurance
Authors: Pikulska D , Kozinoga M , Janusz P , Kotwicki T
Published: June 2021

The study aimed to determine the impact of 6-month rigid brace on back muscle strength and endurance in adolescents with idiopathic scoliosis. Sixty–one girls, aged 7.0–16.0, were analyzed in two groups: the study group (6–month rigid brace wear) vs. the control group (no brace treatment), recruited consecutively and matched for age, body height, weight, BMI, primary curve location and Cobb angle. All patients underwent clinical and radiological examination, modified Biering–Sorensen test, prone and standing maximum strength and endurance tests. No significant difference between groups in back muscles strength or endurance, both gobal and reported to body weight was found. No relation between the daily brace time and the back muscle strength or endurance was observed. The 6–month use of a rigid brace did not affect the strength or endurance of the back muscles in adolescent girls treated for idiopathic scoliosis.
Bracing for infantile scoliosis: no sedation needed
Authors: Hresko MT , Wynne J , Houle L , Miller J
Published: June 2021

Mehta casting technique applied under anesthesia is standard treatment for infantile scoliosis (IIS). However, concern has been raised about frequent anesthesia in children less than three years. The development of a customized thoracolumbar sacral orthosis (TLSO) could avoid the risks of Mehta casting. To develop a bracing technique for IIS that achieves patient compliance and scoliosis correction. Nine patients with ISS were offered a custom TLSO as an alternative to Mehta casting. One patient declined due to an insurance issue. No anesthesia was required for measurement or fitting of the TLSO. A temperature sensitive monitor recorded wear time. Brace success was determined by radiographic correction and adherence to prescription of greater than 18 hours per day. Eight patients had brace treatment with mean(range): age 19(12–44) months, curve magnitude 34° (22–44°), rib vertebral angle of greater than 20° with follow-up 17(3–28) months. In brace correction was less than 15 degrees in 6 of 8 patients. Compliance monitor recorded wear: 4 patients ≥ 18 hours, 2 patients 16–18 hours, 1 had 14 hours, and 1 monitor malfunctioned and could not be read. Brace design evolved to maximize ipsilateral abdominal relief away from the lateral apical shift of the design. Foam lining was added to prevent skin irritation through the relief opening. Average number of braces per year =2.2. A customized TLSO can achieve in brace correction comparable to Mehta casting with acceptable compliance and without the need for general anesthesia, while allowing bathing and skin care.
Spine growth modulation with titanium implant: comparisons to observation and bracing in early adolescent idiopathic scoliosis
Authors: Bylski-Austrow DI , Dolan LA
Published: June 2021

Outcomes of a pilot study of spine growth modulation (GM) were compared to those of untreated and braced patients from a concurrent bracing effectiveness trial (BrAIST). The purpose of this study was to determine probabilities of progression (PP) to fusion indications (≥45°) in a cohort of subjects who underwent GM surgery, and to compare GM outcomes to those of matched BrAIST subjects. Secondary analyses were conducted comparing two prospective longitudinal studies. In one, a vertebral GM system was implanted in 6 highly skeletally immature AIS patients. The control group provided by BrAIST was comprised of a subset of untreated or braced subjects that fit the eligibility criteria of the GM study. GM outcomes were compared to predictions from two prognostic logistic regression models derived from BrAIST to estimate risk of curve progression to ≥45°. If the GM patients were untreated, PPs ranged from 68–98%. If braced for 18 hours/day, progression was expected in two of six, one with a PP of 71%. This latter patient not only did not progress, his curve decreased >20°. In the matched cohort, two were untreated and quickly progressed, whereas two were braced and did not progress. Therefore, the bracing models and matched cohort confirmed the initial assumption that all GM patients were at high risk if untreated. They also supported the probable benefit of the GM system, as 3 of 6 benefited from GM relative to predictions for untreated patients, and one of 6 benefited compared to predictions for highly compliant braced patients.
Is there any difference in pulmonary testing parameters due to spirometry reference values? A study in adolescents with idiopathic scoliosis
Authors: Politarczyk K , Stepniak Ł , Kozinoga M , Kotwicki T
Published: June 2021

The Global Lung Function Initiative (GLI 2012) presented multi-ethnic spirometry reference values that are recommended to be used instead previous Zapletals’ reference values. The study aimed to compare the values of the pulmonary parameters calculated according to the Zapletals’ versus the GLI 2012 reference values in adolescents with idiopathic scoliosis. Preoperative pulmonary testing and radiographic evaluation were performed in 39 adolescents (29 females, 10 males) aged 12–17 years. The thoracic Cobb angle ranged 50°–104°. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were measured. The percentages of predicted values of FVC (%FVC) and the FEV1 (%FEV1) were calculated according to the Zapletals’ reference values and to the GLI 2012 reference values. The subgroup analysis was performed for the subjects with Cobb curve 50°–74° (N=26) versus the subjects with Cobb curve 75°–104° (N=13). Mean %FVC was significantly higher using the Zapletals’ reference values 86.1%±16.4 versus 84.6%±15.6 using the GLI 2012 reference values, p=0.0116. Mean %FEV1 was significantly higher using the Zapletals’ reference values 84.5%±18.2 versus 80.0%±16.3 using GLI 2012 reference values, p=0.000001. The subgroup analysis revealed significant difference of %FVC in moderate (p=0.033974) and no difference in severe curves (p=0.1993). The %FEV1 differences were significant in both moderate (p=0.000011) and severe curves (p=0.0334). The study demonstrated that a significant difference might be observed in the spirometry parameters due to the applied reference values. These differences might be taken into account during the spirometry examination interpretation.
Unemployment and mental health in a community population from a border city in Mexico
Authors: Zamorano González Benito , Peña Cárdenas Fabiola , Pinto-Cortez Cristián , Narváez Yolanda Velázquez , Martínez José Ignacio Vargas , Ramos Luc&a Ruíz
Published: June 2021

BACKGROUND: The constant changes in the global economy generate instability in the markets, favoring the closing of companies, dismissals of personnel, job losses. Unemployment has been associated with adverse psychological effects, serving as a predictor of poor mental health. OBJECTIVE: The main goal was to analyze the relation between work status and mental health. METHODS: A cross-sectional, quantitative study was carried out with a sample of community population, inhabitants of the urban area of a Mexican city. The sample consisted of 1351 participants, being 577 men (43%) and 774 women (57%) with an average age of 41.46 (SD = 17.00). The participants were selected by a quota sampling, in 13 representative points of Matamoros’ city urban area. Home surveys were applied; the Spanish version of the Symptom Checklist 90 (SCL-90) was used for mental health assessment. RESULTS: The model explaining the relation between work status and mental health (GFI) was significant (p < 0.01). Unemployment was related to higher scores in all sub-scales of psychopathologies evaluated by the SCL-90, in comparison with the rest of work status categories. CONCLUSIONS: The unemployed, followed by housewives, presented indicators of poorer mental health, while the retired and those in strikes or lockouts showed the best mental health indexes.
Job stress: Understanding the psychological risk factors of technocrat millennials from the socio-demographic perspective
Authors: Karani Anushree , Jayswal Mitesh
Published: June 2021

BACKGROUND: The Information Technology and Information Technology Enabled Services (IT and ITES) industry has been the backbone of the Indian economy. The sector is characterized by long working hours, strict deadlines, night shift, constant usage of computers, etc. Hence, the industry and nature of the job are influencing the psychological risk factors of the employees. PURPOSE: The purpose of this paper is to explore the psychological risk factors (job stressors) of technocrat millennials and critically analyze them from the socio-demographic perspective. METHODS: A single cross-sectional study with snowball sampling was collected from 300 technocrat millennials in Ahmedabad city (India). Job stressors are examined as psychological risk factors. MANOVA and independent-sample t-test has been put to use for establishing the relationship between psychological risk factors and socio-demographic variables. RESULTS: The study highlighted that the experience, current position, size of family, number of children, gender, and family type had an impact on psychological risk factors of technocrat millennials. CONCLUSIONS: The study contributes to the literature on the psychological risk factors and its association with demographic variables, and specifically in Ahmedabad city (India). Income did not have an impact on psychological risk factor; whereas education was the only demographic variable affecting the responsibility for persons. The experience influenced the role overload, role ambiguity, poor peer relations, and intrinsic impoverishment. The study explained each socio-demographic variable’s impact on 12 psychological risk factors separately. The result of the paper will give insight to HR managers in the recruitment and selection of employees.
Faculty wellness in academic medicine: Addressing stressors in the workplace
Authors: Finkelstein Claudia , Ordway Anne , Johnson Kurt L.
Published: June 2021

BACKGROUND: Burnout is widely regarded as a syndrome resulting from chronic occupational stress. While physician burnout has been the subject of extensive research, physician wellness has been proposed as an alternative framework for understanding physician distress. OBJECTIVE: The purpose of this qualitative study was to understand the organizational context of faculty wellness within an academic health care system. METHODS: Semi-structured interviews were conducted with 24 chairs of clinical and non-clinical departments in a US university school of medicine. RESULTS: Chairs described several system-level factors perceived to interfere with faculty wellness such as a stricter regulatory environment, the loss of professional autonomy, the up or out promotion system, limitless hours, and the rise of shadow work. While all chairs articulated some degree of responsibility for the wellness of their faculty, some said they lacked the skills or knowledge of resources to fully engage in this role. CONCLUSIONS: Findings from this study are consistent with recent research on physician burnout, which has pivoted from describing burnout as an individual responsibility to including the professional, organizational, and societal factors which likely contribute to physician job satisfaction and well-being. As health care organizations, including academic medical centers, move toward systems-based solutions for physician occupational health, it will be incumbent upon organizational leaders to make administrative decisions favoring physician wellness.
Assessment of musculoskeletal disorders among employees working office workplaces in the manufacturing sector
Authors: Kahya Emin
Published: June 2021

BACKGROUND: The number of studies investigating the relationship between office employees and the development of musculoskeletal disorders (MSDs) is limited. Only a few focused on assessing workplace ergonomics of office employees. OBJECTIVE: This study aims to investigate the risk of MSDs and associated factors in the office workplaces of a large-size manufacturing company. METHODS: Data were gathered from 208 office employees from a manufacturing company via Rapid Office Strain Assessment (ROSA) and Cornell questionnaire. The collected data were analyzed to examine the relationship between ergonomic risk levels and MSDs reported by the office staff. RESULTS: The mean ROSA final score is 3.52 (std. dev. = 0.71), chair section is 3.30, monitor and telephone section is 2.18, and mouse and keyboard section is 2.69. Thirty-nine of 208 (18.8%) office workplaces are at risk. The most important factor to raise the risk level is found to be the height and depth of the chair. The Cornell questionnaire results highlight that the highest discomfort severity is related to the neck (32.26%), lower back (23.23%) and upper back (22.26%). The discomforts in the neck (r = 0.362), upper back (r = 0.404) and lower back (r = 0.368) are moderately and positively correlated according to the final ROSA score. The results indicate that the highest risked departments are Accounting, Sub Industry, Production Planning, and Manufacturing Management. CONCLUSION: The parameters associated with the chair section should be considered a priority for reducing and eliminating MSDs among office employees.
Impact of Netspeak on the Writing Skills of Generation X and Generation Y
Authors: Tahir Rameen , Hassan Fiza
Published: June 2021

This research focuses on the impact of netspeak on the formal writing skills of the users.  It is labelled as the hub of slang and informal language content by many experts. The current analysis accounts for  five objectives including the identification of the prime causative factors responsible for deviation in the use of the standard variety, the appliance of the impact of Netspeak on formal writing, the nature of its impact (positive or negative), the assessment of its impact with reference to age and on the basis of the kind of response netspeak receives from the living generations, determining its sustainability.  The objectives are attained through a questionnaire, collecting responses from the individuals belonging to Generation X and Generation Y. This study proposes that the influence of mother tongue and code switching are the prime causative factors of netspeak. The research further showcases the impact of the electronic variety on the users’ formal writing skills which can disturb their formal linguistic framework; however, the variety on its own has been indicated previously as a handy tool for the users. Focusing on the factor of age neutrality, the current study suggests that although Generation X is more inclined towards the use of the standard variety, yet it remains quite open-minded towards the existence and usage of the new variety on social media, stating it to be a “feature of the progressive world”.  The research reflects the enthralling nature of  netspeak which has massively contributed to its popularity. It was inferred that neither the platform (the digital world) is losing its power nor the users are in the mood of giving up on it in the near future. It can be said that it’s a budding variety for the people by the people, born to live, thus strengthening the sustainability argument.
Hybrid Rationality behind Customers’ Choices of the Islamic Banks : An Experience of Bengkulu, Indonesia
Authors: Hardivizon  , Sholihin Muhammad
Published: June 2021

The article aims to reveal the rationality behind the customers’ choices of Islamic banks in Bengkulu province. For this purpose through exploring the possibility of unification between instrumental rationality and Islamic rationality, it will be identified empirically the essence of the customers’ choices of Islamic banks in Bengkulu, Indonesia. The analysis deployed a grounded theory approach. The data obtained was qualitative by involving at least 15 (fifteen) participants who volunteered and spread across several Islamic banks in Bengkulu Province. Therefore, an in-depth interview was conducted as a strategy to collect data related to the rationality behind customers’ choices for the product of Islamic banks in Bengkulu province. The main findings of this study is: “hybrid rationality was successfully identified behind the customers’ choices of Islamic banks in Bengkulu province. This rationality is a unification between instrumental rationality and Islamic rationality based on religiosity values—Sharī‘ah compliance. It is an evidence for categorizing the consumers’ choices of Islamic banks in Bengkulu as “the hybrid rationality.”
A Critical Review of Shamsuddin Azeemi's "Murāqabah" through the Lens of The Qur’ān and Hadīth
Authors: Khalid Iffat , Gulzar Shazia , Amin Muhammad
Published: June 2021

Meditation is an ancient practice that allows people to think about the existence and the main purpose of their lives. It has various forms and is associated with the different religions. Meditation in Islamic societies/cultures is linked with Sufism (Mysticism). During meditation Sufis follow certain practices; most of which are common among different Sufi Schools (Silsila) including Murāqabah. This research article critically analyses the famous practice of Murāqabah, also presented by Khawaja Shamsuddin Azeemi, in his manuscript “Murāqabah: The Art and Science of Sufi Meditation.” Azeemi states that Murāqabah is one of the ways of achieving closeness to Allah and attaining gnosis (maʽrifa Allah). Azeemi has presented Sufi rituals systematically covering the fundamental aspects of meditation (mysticism) that comprises prayer (Du'a), contemplation (Murāqabah), and invocation (Dhikr). Khawaja Shamsuddin Azeemi’s book is a complete manual containing detailed guidelines regarding Murāqabah and its various forms with emphasis that practicing Murāqabah will help “to attain closeness to Allah”. According to the Holy Qur’ān and Hadith, closeness to Allah can be obtained by offering Salah, Tahajjud and sitting for Itikāf in the month of Ramazan. The critical analysis through the lens of the Holy Qur’ān and Hadith shows that neither is the term “Murāqabah” mentioned in the Holy Qur’ān and Hadiths nor is there any evident proof for the diverse rites and rituals associated with the practice of Murāqabah. It is a term coined specifically by the Sufis, along with its various forms and rituals.
The Lanao Sultanate Today: Its Adat Laws and Islamic Law on Fornication with Special Reference to the Islamic Perspectives of al-Māwardī
Authors: M. Hadji Abdul Racman Sohayle , Shakeel Shah Hassan , Ayaz Mohammad
Published: June 2021

The Pat a Pangampong sa Ranao is the archaic name of the four states of Lanao. These four states are Bayabao, Masiu, Unayan, and Baloi which are collectively called the confederate states of Lanao, known as the Lanao Sultanate. This Sultanate was founded by the Lanao chieftains when they seceded Lanao from the Magindanao Sultanate in the 17th century which still exists today. This Sultanate had the traditional laws i.e. Adat laws and Islamic laws. Its political structure consists of traditional leaders and the forty-three sultans who ruled the pagawidan (supported) states and pagawid (supporting) states. Fifteen of these sultans were the executive bodies of the fifteen royal houses of the Lanao Sultanate, while twenty-eight of these sultans were called m’babaya ko taritib who were the legislative bodies and governors of the twenty-eight supporting states of Lanao Sultanate. Today, the Lanao Sultanate operates like the sultanates in Malaysia and Indonesia. Studies specifically dealing from the Sunni Islamic perspective on punishment for Zina (fornication) of the Lanao Sultanate are not represented in literature. This explains why there is a huge research gap on the Sunni Islamic perspective on punishment for fornication in the said sultanate. To fill in this research gap, this paper will explore in-depth the practices of the Royal Court of the said sultanate on punishment for fornication. The findings will be cross-referred to the Qur’ān and Ḥadīth injunctions on punishment for fornication; as well as on al-Māwardī’s Islamic perspectives on punishment for Zina.
Maqasid Sharī‘ah -Based Multidimensional Criticism toward the Implementation of Indonesian Pre-Employment Card (Kartu Prakerja) Program Amidst The Covid-19 Pandemic
Authors: Rosidin  , Andriani Fenty , Fitriani Aprilya
Published: June 2021

Indonesia recognizes the magnitude of the economic impact of Covid-19 outbreak for the low, middle, and high levels. As a solution, the Government has issued the Pre-Employment Card (Kartu Prakerja) Program that provided for households or individuals affected by Covid-19. However, since its launch on April 11, 2020, the Pre-Employment Program has been controversial and criticized by users, public and public figures. Therefore, this research aims to sharpen the criticism of the Pre-Employment Program from the perspective of Maqasid Sharī‘ah  which represents the main objectives of Islamic law, which is multidimensional, because it includes aspects of religion (hifz al-dīn), biopsychology (al-nafs), education (al-‘aql), social (al-nasl) and economic (al-mal). This research applied qualitative research methods of library research and presented in the form of descriptive-analytic. There are five findings of this research. First, from a religious perspective, the implementation of the Pre-Employment Program in the midst of the Covid-19 pandemic brought more harm (mudarāt) than benefit (maslahat). Second, from the perspective of biopsychology, the Pre-Employment Program risks creating doubtful income (shubhat even haram), psychological pressure and nutritional needs neglect. Third, from an education perspective, online training which is part of the Pre-Employment Program, is considered ineffective, both in terms of training materials that do not produce job competence, or training participation which is at risk of fictitious. Fourth, from a social perspective, the Pre-Employment Program creates discriminatory policies, conflicts of interest and human rights violations. Fifth, from an economic perspective, the Pre-Employment Program creates waste, monopoly and the potential for corruption.
INITIAL DEVELOPMENT OF GABIROBA (Campomanesia adamantium) ACCORDING TO FERTILIZATION WITH NITROGEN AND PHOSPHORUS
Authors: Mello Duarte Jéssica Rodrigues de , Basílio Scarlet De Aguiar , Peixoto Nei , Berti Mariana Pina da Silva
Published: June 2021

Campomanesia adamantium (Cambess.) Berg O. is a native of Savanna, popularly known as gabiroba, guavira, or gabiroba-do-campo, and has many uses, with its fruit being consumed fresh or processed. This study aimed to evaluate different doses of phosphorus and nitrogen in the initial development of gabiroba (Campomanesia adamantium) cultivated in pots. Five doses of phosphorus (0, 100, 200, 300, and 400kg ha-1 of P2O5) and three doses of nitrogen (0, 100, and 200 kg ha-1of N) were tested. The experimental design used was completely randomized in a 5x3 factorial scheme with six replications. The evaluations were carried out 120 days after plant emergence, and the variables analyzed were stem diameter, plant height, and number of leaves. Data were subjected to analysis of variance and F-test. The means were compared by the Tukey test at p0.05. Regression analyzes were adjusted for phosphorus doses. The gabiroba responds significantly to the addition of phosphorus, with the dose of 400 kg ha-1 of P2O5 providing the highest height and the dose of 300 kg ha-1 of P2O5 providing the greatest stem diameter and the number of leaves. Up to 120 days old, gabiroba seedlings do not respond significantly to nitrogen fertilization.
Informe especial de estabilidad financiera: inclusión financiera - Primer semestre de 2021
Authors: Clavijo-Ramírez Felipe , Gualtero-Briceño Daniela , Botero Óscar David
Published: June 2021

La inclusión financiera es el proceso de integración de los servicios financieros a las actividades económicas cotidianas de la población, lo cual puede contribuir al crecimiento económico en la medida en que permita reducir los costos de financiación y transacción, y ofrezca un manejo seguro y eficiente de los recursos, tanto para los hogares como para las empresas. La medición de la inclusión financiera abarca diferentes dimensiones del acceso y uso de productos financieros por parte de hogares y empresas, dentro de las cuales se encuentran cobertura, transaccionalidad, ahorro, crédito, seguros, calidad y bienestar. En este informe se presenta un diagnóstico de la inclusión financiera en Colombia diferenciado entre hombres y mujeres. Para esto, se analizan algunas variables relacionadas con inclusión financiera reportadas por el Global Findex para Colombia y otras reportadas en la encuesta de micronegocios del DANE. Adicionalmente, se realiza una comparación entre las características de los créditos otorgados por establecimientos de crédito a mujeres y los otorgados a hombres entre 2017 y 2021 haciendo uso del Formato 341 de la Superintendencia Financiera (SFC). Este documento es el primero en hacer una aproximación a la inclusión financiera con enfoque de género teniendo en cuenta dichos datos administrativos.
In vitro modeling of tumor interclonal interactions using breast cancer cell lines
Authors: Bychkov V.A. , Pevzner A.M. , Nebova J.A. , Ermakova N.N. , Ibragimova M.K. , Tsyganov M.M. , Lyapunova L.S. , Litviakov N.V.
Published: June 2021

Summary. Aim: To study the peculiarities of ecological relationships of breast cancer (BC) cell lines MCF-7, BT-474 and MDA-MD-231 under co-culturing conditions. Materials and Methods: Three BC cell lines: luminal A — MCF-7, luminal B — BT-474 and triple-negative — MDA-MD-231 were co-cultured pairwise. Immunocytochemistry was used to differentiate the cell lines in the wells. The effect of the cell-free culture medium on the growth rate of the alternate cell line in the pair was also evaluated. Results: It was shown that when BT-474 cells were co-cultured with MCF-7 and BT-474 cells were co-cultured with MDA-MD-231, two types of ecological interactions could be observed: commensalism and amensalism, respectively. While the cells do not interact with each other in contact, the supernatants of single cultures of MCF-7 and MDA-MD-231 exert the same effect on BT-474 as co-cultivation of BT-474 with these cells. Conclusions: The paracrine mechanism of intercellular interaction between different human BC cell lines has been demonstrated. The models used in population ecology can be applicable to identify the types of interaction between cell lines.
A variant of TP53 gene (rs 1625895, 13494g>A) is associated with neoplasm localization in patients with uterine leiomyoma
Authors: Kornatska A.G. , Flaksemberg М.А. , Chubei G.V. , Trokhymovych О.V. , Rossokha Z.I. , Fishchuk L.Ye. , Medvedieva N.L. , Vershyhora V.O. , Gorovenko N.G.
Published: June 2021

Summary. Background: Uterine leiomyoma (UL) is the most common benign neoplasm of the uterus. It is still unknown surely what exactly initiates transformation of the uterine myometrial cells into UL. Aim: To study the effect of the TP53 gene variants on the risk of development and clinical features of UL. Materials and Methods: Case-control study was performed using molecular genetic analyses of variants rs1042522 (119 G>C) and rs1625895 (13494G>A) of TP53 gene in patients with UL and comparison group of healthy women. Results: Investigated TP53 gene variants were not associated with the risk of UL development. The patients with the 13494GG genotype (rs1625895) had significantly more often subserous UL (р < 0.05). In patients with heterozygous variant of TP53 — 13494GA genotype (rs1625895) intramural UL was observed (р < 0.05). Conclusions: The rs1625895 (13494G>A) variant of TP53 gene was associated with UL localization. The identified dependence of the UL localization on the TP53 gene variant could be useful for personalized approach to treatment.
Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302а and -377 in tumor tissue
Authors: Vitruk Yu.V. , Semko S.L. , Voylenko O.A. , Pikul M.V. , Borikun T.V. , Zadvornyi T.V. , Yalovenko T.M. , Stakhovsky E.O. , Rossylna O.V.
Published: June 2021

Background: Renal cell carcinoma (RCC) is one of the most common solid tumors in adults highly resistant to conventional therapies. The expression profile of a number of miRNAs correlates with RCC response to chemotherapeutic agents. Aim: To identify the association of tumor miRNAs expression with neoadjuvant treatment response in patients with RCC. Materials and Methods: We analyzed the expression levels of tumor miR-99b, -144, -155, -210, -222, -302а, -377 in 93 RCC patients who received pazopanib or sunitinib in neoadjuvant regimen using RT-PCR. RNU48 was used as a reference miRNA. Results: The levels of expression of miR-99b and -377 are associated with the RCC response to pazopanib, and microRNA-210 and -377 to sunitinib. The characteristic expression profile of miR-99b, -144, -222, -377, and miR-302a determined in 90% of cases was delineated in pazopanib responders as opposed to nonresponders. Similarly, the characteristic expression profile of miR-210, -222, -302a and -377 was suggested for sunitinib responders. Conclusions: Levels of miR-99b, -210 and -377 expression in RCC tumor tissue might be used as a basis for future predictive panel intended for the assessment of the sensitivity to the regimens of neoadjuvant RCC treatment.
TINGKAT MANAJEMEN DAN MANAJER BESERTA FUNGSI-FUNGSI MANAJEMEN
Authors: Anisa Citra Ayu
Published: July 2021

Dalam suatu pekerjaan atau kegiatan terdapat bagian yang sangat penting yang diharuskan ada di setiap pekerjaan atau kegiatan yang biasa disebut dengan bagian manajemen. Dalam sebuah bagian manajemen terdapat kerangka pencapaian tujuan yang dapat dikelompokkan dalam beberapa tingkat manajemen, yaitu Top Management, Middle Management, and Lower Management yang dapat mempermudah pembagian dan pengelolaan tanggung jawab dan penugasan pada setiap kelompok yang dibentuk. Dalam pengelompokan tingkat manajemen tersebut, berdampak pada tipe tanggung jawab dan tugas yang berbeda-beda dari pelaku atau pelaksana yang secara umum disebut dengan manager. Tingkat manajemen dalam organisasi akan membagi manajer menjadi tiga golongan yang berbeda, yaitu Manajer Lini Pertama, Manajer Menengah, dan Manajer Puncak yang memiliki tanggung jawab dan tugas yang berbeda-beda pula.Berdasarkan pernyataan tersebut, dalam proses pelaksanaan manajemen terdapat manajer yang bertanggung jawab untuk pelaksanaan sebuah program manajemen. Dalam hal ini manajer akan melakukan berbagai aktivitas yang dibentuk dari beberapa kegiatan tertentu yang disebut dengan fungsi – fungsi manajemen yang telah disusun dan disepakati sebelum sebuah program manajemen dimulai. Fungsi – fungsi manajemen tersebut adalah faktor yang berperan cukup besar dalam menentukan persentase tercapainya tujuan dari sebuah program manajemen.
Teachers’ understanding towards concepts and processes of children's literacy
Authors: Elfiadi Elfiadi
Published: June 2021

This study aims to describe the understanding and process of implementing literacy in early childhood. The method used in this study is a qualitative descriptive method. Data collection techniques were used through observation, interviews, and documentation. The subjects were Early Childhood Education (ECE) teachers in Lhokseumawe. Ten teachers were selected using purposive sampling technique from five kindergartens; Pertiwi Kindergarten, Bunayya, Safiatuddin and Ukhtani. The results showed that: (1) the understanding of ECE teachers in Lhokseumawe interpreted the concept of literacy as a basic skill that children must have in reading, writing, and speaking. Introduction of literacy for early childhood as initial preparation to master reading, writing and speaking skills so that early childhood becomes more prepared to face education at the next level, Elementary School or Madrasah Ibtidaiyah, (2) The process of implementing literacy in ECE institutions is generally carried out in various forms of play activities and children's daily habit and using various forms of methods and media or educational toys.
Uji Konstruk dan Pengukuran Resiliensi Berdasarkan Jenis Kelamin Menggunakan Analisis Pemodelan Rasch
Authors: Oktasari Maria , Wahyudin Herul
Published: June 2021

This study aims to (1) perform theoretical construct testing on students’ resilience inventory and (2) measuring student’s resilience based on gender. This study used a survey method with a sample of 40 high school students in Bandung. Data analysis used the RASCH model. These research findings show (1) inventory resilience has been fit with the theoretic model, and (2) female student has a tendency to a higher resilience rather than the male student. Furthermore, the measurement of student’s resilience by using this inventory can only produce high measurement information for students who have the intermediate ability. So, the researcher needs to consider eliminating item No. 18 in this inventory due to the biased towards the female gender.
Interaksionisme Simbolik Tagar ShopeeBunuhUMKM DalamTrending Topic Twitter
Authors: Rahma Rosselina Mulya , Pribadi Farid
Published: June 2021

Canggihnya teknologi pada zaman sekarang berdampak pada kemudahan manusia dalam mengerjakan dan melakukan aktivitasnya. Seperti yang kita ketahui, saat ini kita tidak perlu susah-susah membeli sesuatu dengan mengunjungi lokasi perbelanjaan yang hendak dituju. Pada zaman yang serba canggih saat ini kita cukup mengunduh aplikasi belanja online, lalu kita bisa belanja kebutuhan yang kita butuhkan melalui aplikasi tersebut. Harga-harga barang dalam aplikasi tersebut juga beragam ada yang paling murah hingga paling mahal. Selain itu, kita juga bisa membeli barang-barang dari luar negeri dengan harga yang cukup murah. Pada Februari 2021, ada sebuah pagar yang sempat menjadi trending topic di Twitter, yaitu #ShoppeBunuhUMKM. Banyak juga warganet Indonesia yang ikut menulis cuitannya di Twitter perihal #ShopeeBunuhUMKM. Oleh karena itu peneliti tertarik untuk melakukan sebuah penelitian terhadap #ShopeeBunuhUMKM dengan menggunakan teori interaksionisme simbolik. metode penelitian yang akan dilakukan dalam penelitian ini adalah metode penelitian kualitatif. Hasil penelitian ini menunjukkan bahwa ternyata ada pro dan kontra yang terjadi dalam #ShopeeBunuhUMKM dalam trending topic Twitter.
Pembentukan Keluarga Shaleh Dalam Komunikasi Islam: Studi Komparasi Penafsiran Al-Qur’an
Authors: Roni Muhammad , Anzaikhan M.
Published: June 2021

Pembentukan keluarga shaleh seharusnya bukan hanya dimulai ketika dalam masa kandungan, lebih dari itu Islam melalui sumber ajarannya menuntun umatnya untuk memulai membentuk keluarga shaleh dimulai dari cara dan kriteria memilih pasangan hidup yang tepat. Memilih pasangan hidup dan mendidik anak semuanya membutuhkan komunikasi yang ideal sebagaimana yang dianjurkan dalam Al-Quran. Metode  penelitian   yang   akan  penulis   gunakan   adalah komparasi analisis teks terhadap tafsir-tafsir Al-Quran. Teknik pengumpulan data bagi penelitian ini adalah studi perpustakaan yaitu dengan menelaah bahan-bahan dari teori-teori yang berhubungan dengan permasalahan yang dibahas berdasarkan buku-buku yang berhubungan serta dapat mendukung atau menyokong penelitian penulis. Sumber data primer adalah ayat-ayat Al-Quran yang dipilih beberapa ayat-ayat tentang keluarga shaleh dan komunikasi dalam Islam. Hasilnya, ditemukan Kata ‘shaleh’ atau ‘saleh’ sebanyak 143 kali dalam Al-Quran, sedangkan kata ‘keluarga’ ditemukan 67 kali. Setelah dilakukan penelitian maka dapat disimpulkan bahwa Allah menginformasikan dalam Al-Quran dalam membentuk keluarga shaleh sangat dipengaruhi oleh faktor komunikasi baik dalam hidup berindividu maupun kelompok.
Pendidikan Karakter Berbasis Keluarga Pada Kisah Nabi Ibrahim dan Ismail
Authors: Fadli Saiful
Published: June 2021

Abstract

This paper discusses the family-based character education model. This article specifically examines the link between the story of Ibrahim and Ismail with character education and how to apply the concept of character education that Ibrahim has done to his son Ismail in the family. This research is literary research that uses the Tafsir Maudui method, namely by gathering verses related to the topic of discussion and interpreting them and referring to interpretive books and then analyzing these data with theories and references that support the analysis of the data. This research found that the success of the Prophet Ibrahim in educating his son because it makes monotheism as the main foundation. Ishmael since childhood has been introduced to the values of God. From obedience to God comes obedience to parents. Monotheism education gave birth to a patient child. Patience is one of the main characteristics that must be possessed by human children to become a perfect per-son.

Abstrak

Artikel ini membahas model pendidikan karakter berbasis keluarga Artikel ini secara khusus meneliti kaitan kisah Ibrahim dan Ismail dengan pendidikan karakter dan cara mengaplikasikan konsep pendidikan karakter yang telah dilakukan Ibrahim terhadap putranya Ismail dalam keluarga. Penelitian ini merupakan penelitian literatur yang menggunakan metode tafsir maudui, yaitu dengan mengumpulkan ayat-ayat yang berkaitan dengan topik bahasan dan menafsirkannya dan merujuk pada kitab-kitab tafsir lalu menganalisis data-data tersebut dengan teori dan referensi yang mendukung penganalisisan data. Penelitian ini menemukan bahwa keberhasilan Nabi Ibrahim dalam mendidik putranya karena menjadikan tauhid sebagai fondasi utama. Ismail semenjak kecil sudah dikenalkan dengan nilai-nilai ketuhanan. Dari kepatuhan kepada Tuhan berbuah kepatuhan kepada orang tua. Pendidikan tauhid melahirkan anak yang penyabar. Sabar adalah satu karakter utama yang harus dimiliki anak manusia untuk menjadi insan paripurna.
Konsep Diri dan Hasil Belajar Siswa MAN 1 ACEH TIMUR
Authors: Furaida
Published: June 2021

The self-concept is the center of personality which is a real picture of a person's self, both from an individual's understanding of what and who he is so that individuals can understand himself well. Self-concept is very important, because with a positive self-concept, a person will be more confident with all his strengths and weaknesses. This is related to one's ability to use cognitive abilities according to optimal potential. So, self-concept with learning outcomes are related to each other, a close relationship and useful in achieving success. Likewise, students of MAN 1 Aceh Timur who have a positive self-concept will be successful in participating in teaching and learning activities and in their lives. Self-concept is the center of personality which is a real picture of a person, both from an individual's understanding of what and who he is so that individuals can understand himself well. Self-concept is very important, because with a positive self-concept, a person will be more confident with all his strengths and weaknesses. This relates to a person's ability to use cognitive abilities in accordance with optimal potential. For that, it takes motivation and support from parents, family, and the environment so that students have a positive self-concept in seeing themselves. High self-confidence can increase self-confidence in learning, consequently increasing student learning outcomes. Belief in one's ability to pursue every process in teaching and learning activities is an advantage and a necessity in the world of education. With hope, students who have a positive self-concept will be more successful in pursuing the long path of education and also in post-education life.
Broad-winged Hawk Buteo platypterus (Aves: Accipitridae): An addition to the Paraguayan Avifauna
Authors:   Facultad de Ciencias Agropecuarias y Forestales, Universidad Nacional de Itapúa, Artigas, Paraguay., PAREDES JOSE , CLAY ROB ,   WHSRN Executive Office, Manomet, Inc., PO Box 1770, Manomet, Massachusetts 02345, CLAY MATTHEW ,   Colegio Salesianito, Asunción, Paraguay, SMIT H PAUL ,   FAUNA Paraguay, Encarnación, Paraguay, www.faunaparaguay.com and Para La Tierra, Centro IDEAL, Mariscal Estigarribia 321 c/ Tte. Capurro, Pilar, Ñeembucú department, Paraguay.
Published: June 2021

The first Paraguayan records of the Broad-winged Hawk Buteo platypterus are reported from Itapúa and Central departments.
STUDY OF MORPHOLOGY AND HISTOLOGY OF PLACENTA IN HYPERSENSITIVE MOTHERS
Authors: Gajbhiye Nisha , Gajbhiye Sachin
Published: June 2021

Background: Hypertensive pregnancy may be responsible for vascular damage, enhanced systemic inflammation and insulin resistance in the placenta as oxygen and nutrient transfer is impaired and oxidative stress is generated affecting the placental growth and development. Placental growth pattern in hypertensive pregnancies shows a variable pattern owing to placental insufficiency. Method: The study was carried out on 80 sets placentae, mothers and their babies. The placentae were collected from Obstetrics & Gynecology Department of NSCB Medical College Jabalpur. Out of 80 placentae, 40 were from normal pregnant mothers and 40 from pregnancies complicated by PIH in previously normotensive women, serial number of placentae, mother and baby were same. placentae were  collected soon after the normal vaginal delivery or caesarian section along with 10 cm long stump of umbilical cord. Aims and objectives: The aim of this study was to determine whether maternal PIH would affect the morphology and histology of placenta and compare this with that of normotensive mothers. It was a cross-sectional comparative study carried out at the maternity ward and anatomy department of NSCB Medical College, Jabalpur. Result: A Macroscopic study of the placenta revealed placental weight, placental volume, diameter, placental thickness and number of cotyledons were less in study group. Mean placental weight in study group was 336gm and in control group was 425 (p<0.05). Mean placental volume in study group & control group were 236and352 ml respectively (p<0.05). Mean number of cotyledons were 14.7and 16 in study & control group respectively but not significant and mean diameter15.6 cms and17.05cms in study and control group. But in the present study placental thickness was not significant (p<0.539). There was a single umbilical artery present in one patient in PIH group.  All morphometric parameters of placenta weight, volume, diameter, thickness, no. of cotyledons were reduced.

Histological findings were cytotrophoblastic cellular proliferation, syncitial knot formation, fibrin plaque formation. In 20 percent cases, villi were hypovascular. The hypovascular villi have abundance of syncitial knots, usually lack vasculosyncitial membrane and increased stromal collagen. Conclusion: PIH adversely affect both morphology and histology of placenta.

Keywords: morphology, histology, placenta, hypersensitive & mothers.