bluuebunny/crossref_metadata_2025 huggingface dataset:
Elements of Post-Transplant Recovery in Lung Transplant Recipients: A Scoping Review
Authors: Wang Ruiting , Peng Fucong , Guo Shaobo , Sun Jing , Zhang Shuping , Li Xiangru , Wei Changyun , Liu Hongxia
Published: May 2024

To clarify and refine the specific elements of post-transplant recovery in lung transplant recipients, we explored the four dimensions of recovery: physiological, psychological, social, and habitual. This study is a scoping review. Two authors conducted a comprehensive electronic literature search to identify studies published from the establishment of the database to August 2022. Deductive coding was utilized to identify and categorize elements using a predefined list of the four components (physiological, psychological, social, and habitual recovery) based on the framework of post-transplant recovery proposed by Lundmark et al. Inductive coding was applied for concepts requiring further classification. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guideline. Systematic searching identified 8,616 potential records, of which 51 studies met the inclusion criteria. Ten subdimensions and their corresponding elements were identified and categorized into four dimensions of recovery following lung transplantation. The subdimensions included physiological recovery (including symptom experience, complications, physical function, and energy reserve), psychological recovery (encompassing affective distress, psychological adaptation, and transition from illness to health), social recovery (involving family adaptation and social adaptation), and habit recovery (focusing on health behavior).
Involvement of circRNA Regulators MBNL1 and QKI in the Progression of Esophageal Squamous Cell Carcinoma
Authors: Wang Hai-Feng , Zhou Xiao-Feng , Zhang Qun-Mei , Wu Jie-Qing , Hou Jing-Han , Xu Xue-Lian , Li Xiu-Min , Liu Yu-Long
Published: May 2024

Objectives

To investigate the role of circRNA regulators MBNL1 and QKI in the progression of esophageal squamous cell carcinoma.

Background

MBNL1 and QKI are pivotal regulators of pre-mRNA alternative splicing, crucial for controlling circRNA production – an emerging biomarker and functional regulator of tumor progression. Despite their recognized roles, their involvement in ESCC progression remains unexplored.

Methods

The expression levels of MBNL1 and QKI were examined in 28 tissue pairs from ESCC and adjacent normal tissues using data from the GEO database. Additionally, a total of 151 ESCC tissue samples, from stage T1 to T4, consisting of 13, 43, 87, and 8 cases per stage, respectively, were utilized for immunohistochemical (IHC) analysis. RNA sequencing was utilized to examine the expression profiles of circRNAs, lncRNAs, and mRNAs across 3 normal tissues, 3 ESCC tissues, and 3 pairs of KYSE150 cells in both wildtype (WT) and those with MBNL1 or QKI knockouts. Transwell, colony formation, and subcutaneous tumorigenesis assays assessed the impact of MBNL1 or QKI knockout on ESCC cell migration, invasion, and proliferation.

Results

ESCC onset significantly altered MBNL1 and QKI expression levels, influencing diverse RNA species. Elevated MBNL1 or QKI expression correlated with patient age or tumor invasion depth, respectively. MBNL1 or QKI knockout markedly enhanced cancer cell migration, invasion, proliferation, and tumor growth. Moreover, the absence of either MBNL1 or QKI modulated the expression profiles of multiple circRNAs, causing extensive downstream alterations in the expression of numerous lncRNAs and mRNAs. While the functions of circRNA and lncRNA among the top 20 differentially expressed genes remain unclear, mRNAs like SLCO4C1, TMPRSS15, and MAGEB2 have reported associations with tumor progression.

Conclusions

This study underscores the tumor-suppressive roles of MBNL1 and QKI in ESCC, proposing them as potential biomarkers and therapeutic targets for ESCC diagnosis and treatment.
Microglia, Trem2, and Neurodegeneration
Authors: Shi Qian , Gutierrez Raul A. , Bhat Manzoor A.
Published: May 2024

Microglia are a specialized type of neuroimmune cells that undergo morphological and molecular changes through multiple signaling pathways in response to pathological protein aggregates, neuronal death, tissue injury, or infections. Microglia express Trem2, which serves as a receptor for a multitude of ligands enhancing their phagocytic activity. Trem2 has emerged as a critical modulator of microglial activity, especially in many neurodegenerative disorders. Human TREM2 mutations are associated with an increased risk of developing Alzheimer disease (AD) and other neurodegenerative diseases. Trem2 plays dual roles in neuroinflammation and more specifically in disease-associated microglia. Most recent developments on the molecular mechanisms of Trem2, emphasizing its role in uptake and clearance of amyloid β (Aβ) aggregates and other tissue debris to help protect and preserve the brain, are encouraging. Although Trem2 normally stimulates defense mechanisms, its dysregulation can intensify inflammation, which poses major therapeutic challenges. Recent therapeutic approaches targeting Trem2 via agonistic antibodies and gene therapy methodologies present possible avenues for reducing the burden of neurodegenerative diseases. This review highlights the promise of Trem2 as a therapeutic target, especially for Aβ-associated AD, and calls for more mechanistic investigations to understand the context-specific role of microglial Trem2 in developing effective therapies against neurodegenerative diseases.
Autoethnography: An (Incomplete) Abecedarian Assemblage
Authors: Badley Graham Francis
Published: May 2024

I found Sheila Heti’s Alphabetical Diaries so engrossing that I decided to construct an experimental assemblage based partially on her somewhat playful yet serious alphabetical reconfiguring of her diaries. In my case, I used items selected mainly from various articles I have written concerning autoethnography following Heti’s rather chaotic methodology.
How and Why People Synchronize: An Integrated Perspective
Authors: daSilva Elizabeth B. , Wood Adrienne
Published: May 2024

Academic Abstract

Interpersonal synchrony, the alignment of behavior and/or physiology during interactions, is a pervasive phenomenon observed in diverse social contexts. Here we synthesize across contexts and behaviors to classify the different forms and functions of synchrony. We provide a concise framework for classifying the manifold forms of synchrony along six dimensions: periodicity, discreteness, spatial similarity, directionality, leader–follower dynamics, and observability. We also distill the various proposed functions of interpersonal synchrony into four interconnected functions: reducing complexity and improving understanding, accomplishing joint tasks, strengthening social connection, and influencing partners’ behavior. These functions derive from first principles, emerge from each other, and are accomplished by some forms of synchrony more than others. Effective synchrony flexibly adapts to social goals and more synchrony is not always better. Our synthesis offers a shared framework and language for the field, allowing for better cross-context and cross-behavior comparisons, generating new hypotheses, and highlighting future research directions.
Commentary: Company Innovativeness: A Radically New Perspective on an Old Concept
Authors: Kunz Werner H.
Published: May 2024

The article highlights misconceptions around the concept of innovativeness and argues for a broader understanding that encompasses both inward and outward-looking perspectives. It emphasizes the importance of perceived innovativeness as influenced by marketing, innovation culture, leadership, and emotional connection with customers. This customer-centric viewpoint not only offers a fresh lens through which to evaluate firm innovativeness but also underscores its significant implications for innovation management and future research directions.
Long peripheral catheters for intravenous infusions of iloprost or alprostadil therapy in rheumatologic outpatients
Authors: Donadoni Mattia , Calloni Maria , Romano Maria Eva , Mutti Alessandra , Bartoli Arianna , La Cava Leyla , Celano Rosita , Urso Francesco , Popescu Janu Valentina , Foschi Antonella , Casella Francesco , Taino Alba , Cogliati Chiara , Zappa Paolo , Masseroli Matteo Maria , Gidaro Antonio
Published: May 2024

Background:

Long peripheral catheters (LPCs) role in Difficult IntraVenous Access (DIVA) patients admitted to the emergency department has already been studied, resulting in a rapid, safe, and cost-effective procedure. Although their use in outpatient settings is established, there is a lack of studies assessing their benefits. In particular, rheumatologic outpatients affected by scleroderma, especially those affected by digital ulcers, are often treated with intravenous infusions of prostaglandin I2 (PGI2) analog (IV-PGI2A).

Objective and methods:

From 1 October 2021 to 31 March 2024, we conducted a prospective study enrolling DIVA outpatients affected by systemic sclerosis or undifferentiated connective tissue disease who needed IV-PGI2A therapy at L. Sacco Hospital in Milan (Italy). Each treatment cycle consisted of four consecutive days of infusion of iloprost or alprostadil. The primary aim was to assess the efficacy and potential complications associated with LPCs for IV-PGI2A.

Results:

Twenty-six patients were enrolled 23 were females (88.5%), and the median age was 72 years (IQR 56–78.7). In total, 97 LPCs were inserted, with a mean number of insertions per patient/year of 2.3. An increase in LPCs insertion during the 30 months of the enrollment period was observed. Eighteen patients required more than one LPC placement, and in 61% of them, the second venipuncture was executed at a different site. No procedural complications were registered (accidental puncture of the brachial artery, accidental median nerve puncture, bleeding) nor late complications (Catheter-Related Thrombosis, Catheter-Related Bloodstream Infections, Accidental Removal).

Conclusions:

Our experience shows that LPCs could be valuable and safe for rheumatologic outpatients. The increased number of insertions and new and total patients enrolled each year defines the satisfaction of patients and health care professionals.
Association Between Ki-67 Proliferative Index and Oncotype-Dx Recurrence Score in Hormone Receptor-Positive, HER2-Negative Early Breast Cancers. A Systematic Review of the Literature
Authors: Mooghal Mehwish , Khan Muhammad Ali Akbar , Samar Mirza Rameez , Shaikh Hafsa , Valimohammad Azmina Tajdin , Idrees Romana , Abdul Rashid Yasmin , Sattar Abida K
Published: May 2024

Background:

Oncotype-Dx (ODx) is a 21-gene assay used as a prognostic and predictive tool for hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative, node-negative, or 1 to 3 lymph node-positive early breast cancers (EBCs). The cost of the test, which is not available in low-middle income countries (LMICs), is not within the means of most individuals. The Ki-67 index is a marker of tumor proliferation that is cost-effective and easily performed and has been substituted in many cases to obtain prognostic information.

Objective:

We aimed to identify the correlation between the ODx recurrence score (RS) and the Ki-67 index in HR-positive EBCs and to determine whether Ki-67, like the ODx, can help facilitate clinical decision-making.

Design:

Systematic review correlating Ki-67 index and ODx in HR-positive and HER2-negative EBCs as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Data sources and methods:

We searched different databases between January 2010 and May 2023 and included retrospective/prospective cohorts, clinical trials, case-control, and cross-sectional studies involving HR-positive and HER2-negative EBCs correlating the Ki-67 index and ODx RS categories.

Results:

Of the 18 studies included, 16 indicated a positive or weakly positive correlation between ODx and the Ki-67 index. The combined P value of the included studies is <0.05 ( P = .000), which shows a statistical significance between the 2. Our review also discusses the potential of machine learning and artificial intelligence (AI) in Ki-67 assessment, offering a cost-effective and reproducible alternative.

Conclusion:

Even although there are limitations, studies indicate a favorable association between ODx and the Ki-67 index in specific situations. This implies that Ki-67 can offer important predictive details, especially regarding the likelihood of relapse in HR-positive EBC. This is particularly significant in LMICs where financial constraints often hinder the availability of costly diagnostic tests.
Digitalization of cultural industries: Evidence from the official Spider-Man movie TikTok account
Authors: Hernando Velasco Alicia , Matsumoto Mitsuko , Dominguez-Santos Susana , Lacasa Pilar
Published: May 2024

The digitalization of culture and creative industries has presented both challenges and opportunities. To effectively engage audiences and ensure their constant interest, these industries must continually adapt their circulation strategies. The objectives of this study are threefold: 1) analyze the strategies employed by the Marvel Cinematic Universe (MCU) to engage with the fan community; 2) examine the interplay between fiction and reality based on the relationships between characters and actors, as shown in social network posts; and 3) determine how the discourse in the film ‘Spider-Man: No Way Home’ is reconstructed on TikTok, leveraging its particular ‘affordances’ (Gibson, 1979). A mixed methodology approach was utilized, combining the use of Analisa.io software to provide a comprehensive view of the Spider-Man official account’s activities and user engagement with a detailed analysis of the thematic, multimodal, and discursive aspects of TikTok videos published by the account. The findings reveal that the MCU employs TikTok as a marketing tool for the new movie, utilizing three main strategies that align with the characteristics of transmedia storytelling and enhanced audience engagement: 1) strategic selection of publication moments for the growth of follower engagement; 2) extensive use of teasers; and 3) leveraging the presence of actors as a key element to facilitate fan identification.
An ecological inquiry into the identity formation of a novice TESOL research mentor: Critical autoethnographic narratives in focus
Authors: Kamali Jaber
Published: May 2024

This study reports on the identity formation of the author as a novice research mentor of an independent research course for TESOL teachers over six months (from the course design to the first research submission). The data is collected from four critical autoethnographic narratives written by the author before, during, and after this period. The narratives were analysed thematically with an eye on the theoretical underpinning of the study, i.e. ecological perspective, in three ecological layers namely micro-, meso-, and macrosystem. The results revealed that the author’s identity construction was influenced by different factors such as ‘autonomy in mentoring’, ‘mediating mentorship’, or ‘academic recognition’ in three levels of educational ecology. The results of this study can motivate research mentors and teacher educators, specifically novice ones, to find some similarities with the ideas discussed in this research and to record their lived experiences as a tool for reflection.
In/visible hurdles: US collegiate esports participants’ perceived barriers to play and involvement
Authors: Wilson Andrew J , Cote Amanda , Foxman Maxwell , Harris Brandon , Hansen Jared , Can Onder , Rahman Md Waseq Ur
Published: May 2024

Gaming and esports communities possess cultural barriers that exclude potential participants, limiting their access to social, cultural, and economic opportunities. In the United States, for instance, varsity esports players are increasingly supported by scholarships and tournament prizes, but persistent challenges make these benefits accessible to only a limited portion of the student body. Using a grounded theory analysis of 31 in-depth interviews with collegiate esports players, administrators, and student workers, this study examines perceived barriers and their (in)visibility to different participants. We find that gender and race are readily acknowledged, while other identities (age, physical ability, etc.) are overlooked. Moreover, visibility did not necessarily correlate with meaningful strategies for inclusion. While collegiate esports could be a welcoming and equitable environment, these findings suggest it will not be so until all hurdles are (1) made visible and (2) addressed relative to a university’s own student body composition.
Rituals of nonbelonging and their emotional toll: Encounters with the orthodox Jewish weddings and burials among generation 1.5 former Soviet Union immigrants in Israel
Authors: Prashizky Anna
Published: May 2024

This article examines the encounters of Generation 1.5 Jewish immigrants from the former Soviet Union (FSU) with the Orthodox establishment within the framework of weddings and burials in Israel. These Orthodox Jewish weddings and burials are referred to here as rituals of nonbelonging and provide a lens for understanding the role of rituals in the marginalisation and exclusion of immigrants and ethnic minorities from religious and national collectives. The article argues that rituals of nonbelonging originate in the more extensive politics of nonbelonging and reflect an exclusion that provokes negative emotions among marginalised minorities due to the perceived threats to social bonds.
Examining facilitator experiences delivering an intervention to system-involved women with mental illnesses
Authors: Parisi Anna , Blank Wilson Amy , Farkas Kathleen , Brown Suzanne , Villodas Melissa , Phillips Jon
Published: May 2024

Gender differences have been found in the experiences and needs of individuals involved in the criminal legal system, underscoring the importance of interventions tailored to address the needs of system-involved women. Despite this recognition, there remains a gap in understanding how to effectively implement interventions for women with mental illnesses—a population that is increasingly prevalent within correctional facilities. This qualitative study examined facilitator experiences delivering a cognitive behavioral intervention to incarcerated women with mental illnesses. Qualitative open coding techniques were used to analyze facilitator notes from each session to learn more about the challenges facilitators experienced and the strategies they used to address them. Teaching interpersonal conflict skills was identified as the primary challenge facilitators faced throughout intervention delivery. Two aspects of teaching interpersonal conflict skills were found to be particularly difficult: how facilitators worked with participants to identify interpersonal conflicts, and how facilitators fostered discussions of conflict during intervention sessions. This study provides initial insights into the complexities inherent in delivering interventions to system-involved women with mental illnesses. Our results highlight the need for future research and interventions that address dynamics at the intersection of interpersonal conflict, gender, and mental illness.
Small-sample damage detection of bleacher structure based on GAN and MSS-CNN models
Authors: Cai Chaozhi , Guo Xiaoyu , Ren Jianhua , Xue Yingfang
Published: May 2024

The damage scales and forms of bleacher structure are diverse, and the training by using neural network models may be inadequate when the data sample is limited, resulting in challenges such as overfitting or the inability to generalize new damage scenarios. In order to address the issue of damage detection in bleacher structures with small samples, this paper proposes a multi-scale stride convolutional neural network (MSS-CNN) model. It is trained as a generator and discriminator within a generative adversarial network (GAN) framework. By utilizing GAN to generate data and integrating real data with generated data, the mixed data is input into the MSS-CNN model for training, ultimately yielding damage detection results. In order to validate the effectiveness of this approach, a series of experimental studies are conducted by using a bleacher simulator at Qatar University as the research subject. Furthermore, the model is compared with ResNet, multi-layer perceptron, and support vector machine under identical experimental conditions by comparing real and mixed data. The experimental results consistently demonstrate the superior performance of the MSS-CNN model across multiple experiments. This paper presents a fresh research approach and perspective for addressing the challenge of small-sample damage detection in bleacher structures.
Systematic Review of Intimate Partner Violence Interventions for Latinas in the U.S
Authors: Cardenas Iris , Fraga Rizo Cynthia , Ward Malorie , Jiwatram-Negrón Tina
Published: May 2024

Despite increased risks associated with intimate partner violence (IPV) among Latinas, there is limited knowledge about interventions focused on preventing and responding to IPV among this group or the culturally relevant components of these interventions. To address this gap, we conducted a systematic review of IPV interventions for Latinas. To be included in the review, articles had to be peer-reviewed and available in English or Spanish; evaluate an IPV intervention conducted in the U.S. (including Puerto Rico); include Latinas; and quantitatively report at least one outcome. Our initial search yielded 3,344 unduplicated peer-reviewed articles, of which 20 met the inclusion criteria. The 20 resultant articles evaluated 14 unique interventions among 16 different study samples. Half of the studies focused on interventions that aimed to prevent IPV, whereas the other half focused on interventions that aimed to respond to IPV (i.e., provide services to those who had experienced or were experiencing IPV). Eight of the 14 interventions integrated culturally specific elements. While six studies were randomized controlled trials, most were pre-experimental in design. Interventions generally demonstrated positive outcomes on various measures. However, nine interventions reported mixed findings, emphasizing the complex factors influencing IPV among Latinas. Findings suggest the need for more mechanistic and nuanced research on potentially relevant culturally responsive content and approaches in IPV programming with Latinas, focusing on cultural strengths and structural challenges. Policies are needed to expand funding for innovative and rigorous IPV intervention research to further advance and strengthen existing practice options for Latina survivors.
Automated Name Selection for the Network Scale-up Method
Authors: Fenoy Adrià , Bojanowski Michał , Lubbers Miranda J.
Published: May 2024

To estimate the distribution of the number of acquaintances of the members of a society, the network scale-up method asks survey respondents about the number of people they know with features for which national statistics are available. While many features have been used for this purpose, first names have been suggested to produce particularly low levels of transmission error and recall bias. For this method to be precise, a set of names needs to be selected for the survey that jointly represents the population in relevant variables such as gender or age. This article provides a solution approach to finding the optimal set of names. This can be applied to any population for which a joint distribution of first names and relevant variables is available. We show that our approach successfully provides sets of names closely mirroring the population distributions for six countries with different name statistics.
How Passion for Work Shapes Work-Family Interactions: A Conceptual Framework Exploring the Roles of Psychological Capital and Self-Regulation Failure
Authors: Chandran Sreelekshmi , Vijayalakshmi V. , Fiedler Marina
Published: May 2024

The belief that a life of passion is a life well-lived serves as a perpetual motivator to pursue work aligned with one’s passion. Both work and family are essential life domains in many people’s lives, and they often interconnect, impacting each other. In the workplace, passion is a highly desired but under-researched employee characteristic, offering benefits like positive emotions and improved performance but also carrying risks, such as inflexibility. Drawing on job demands-resources theory and conservation of resources theory, our inquiry offers an integrative conceptual framework that combines insights from positive psychology, organizational behavior, and human resource development (HRD) literature. This framework enhances our understanding of how work passion connects to the work-family interface, considering the roles of psychological capital and self-regulation failure in interactions beyond work. Our study includes implications for HRD practitioners motivated to promote change initiatives and an agenda for future research for HRD scholars.
Venous Stasis Ulceration due to Massive Splenomegaly Causing Iliac Vein Compression From Secondary Myelofibrosis
Authors: Dong Henry W. , Hernandez Lucille , Ghahremani Jacob S. , Chapek Michael A. , Safran Brent A. , Lau David L. , Brewer Michael B.
Published: May 2024

Venous stasis ulcers are nonhealing lesions due to venous hypertension secondary to valvular dysfunction or deep venous outflow obstruction. We describe a case of a 71-year-old male with a history of polycythemia vera, secondary myelofibrosis, and massive splenomegaly up to 38 cm who presented with chronic, perimalleolar venous stasis ulcers and pain on the left lower extremity. CT showed significant compression of the left common iliac vein due to mass effect from the spleen. He was managed medically while being evaluated for partial splenic artery embolization but expired due to other chronic conditions before any intervention could be performed. Partial splenic artery embolization may be considered as a treatment option for patients with symptomatic iliac vein compression due to massive splenomegaly secondary to myelofibrosis, as long as extramedullary hematopoiesis is not compromised.
Student interactions with ethical issues in the lab: results from a qualitative study
Authors: Laas Kelly , Miller Christine Z , Brey Eric M , Hildt Elisabeth
Published: May 2024

Student researchers encounter ethical issues daily, but little is known about their unique perspectives. This article presents the results of 30 qualitative semi-structured interviews exploring students’ views and experiences around ethical issues in research groups. During the interviews, students were asked to describe challenges and successes they have encountered in their lab, their conception of what counts as an “ethical issue in research,” and how they handle these issues when they arise. Against this background, the article discusses students’ conceptions of ethical issues in research environments, the types of issues students reported facing, how these issues were ultimately resolved, and finally, the factors, internal qualities, and lessons learned that help students thrive in research environments, as well as some of the challenges students face – especially international students. Many of the ethical challenges interviewees discussed focused on interpersonal issues, highlighting the intense collaboration most graduate students have with their colleagues and supervisors. Findings from this study point to the need for targeted training programs for students and faculty supervisors focusing on building mentoring relationships and finding space in the lab where open communication can occur around ethical research practices.
Systematic review of recent advancements in antibody-drug and bicycle toxin conjugates for the treatment of urothelial cancer
Authors: Domb Chaim , Garcia Jorge A. , Barata Pedro C. , Mendiratta Prateek , Rao Santosh , Brown Jason R.
Published: May 2024

Antibody-drug conjugates and bicycle toxin conjugates represent a tremendous advance in drug delivery technology and have shown great promise in the treatment of urothelial cancer. Previously approved systemic therapies, including chemotherapy and immunotherapy, are often impractical due to comorbidities, and outcomes for patients with advanced disease remain poor, even when receiving systemic therapy. In this setting, antibody-drug and bicycle toxin conjugates have emerged as novel treatments, dramatically altering the therapeutic landscape. These drugs harness unique designs consisting of antibody or bicycle peptide, linker, and cytotoxic payload with more targeted delivery than conventional chemotherapy, thus eliminating malignant cells while reducing systemic toxicities. Potential targets investigated in urothelial cancer include Nectin-4, TROP2, HER2, and EphA2. Initial clinical trials demonstrated efficacy in treatment of refractory advanced urothelial cancer, as well as improvement in quality of life. These initial studies led to FDA approval of two antibody-drug conjugates, enfortumab vedotin and sacituzumab govitecan. Moreover, antibody-drug and bicycle toxin conjugates are being studied in ongoing clinical trials in frontline treatment of advanced disease as well as for localized cancer. These studies highlight the potential for additional future therapies with novel targets, novel antibodies, cytotoxic and immunomodulatory payloads, and unique structural designs enhancing efficacy and safety. There is increasing evidence that combinations with other cancer therapies, especially immunotherapy, improve treatment outcomes. The combination of enfortumab vedotin and pembrolizumab was recently approved for first-line treatment of advanced urothelial carcinoma. Despite the great promise of these novel drugs, robust predictive biomarkers are needed to determine the patients who would maximally benefit. This review surveys the rationale and current state of the evidence for these new drugs and describes future directions actively being explored.
Timing of Surgery and Outcomes in Chronic Rhinosinusitis: A Narrative Review and Meta-Analysis
Authors: Bell Christopher M. , Yip Jonathan
Published: May 2024

Background

Surgery is often indicated in the treatment of medically recalcitrant chronic rhinosinusitis (CRS). There is conflicting evidence on the impact of timeliness of sinus surgery on the degree of perceived symptom improvement in CRS.

Objective

The goal of this study was to systematically evaluate the available literature on the relationship between patient wait times for endoscopic sinus surgery (ESS) and postoperative changes in patient-reported outcome measures.

Methods

Ovid, MEDLINE, CINAHL, and Cochrane Library of Systematic Reviews between January 2000 and September 1, 2023, were searched. A total of 931 studies were independently screened by 2 reviewers. Two studies were included in the meta-analysis, while 4 others were included in a narrative review.

Results

Two studies consisting of 1606 patients were included in the meta-analysis. A mean difference in 22-Item Sino-Nasal Outcome Test (SNOT-22) of −0.3 (95% CI = −3.9 to 3.3, I2 = 89%, P < .01 was observed between “long” and “short” groups, while a mean difference in SNOT-22 of −0.1 (95% CI = −2.5 to 2.3, I2 = 80%, P = .03) was observed between “long” and “mid” groups. Patients who receive surgery earlier on their disease process (ie, earlier from the time of diagnosis to eventual surgery) appear to require less access to healthcare resources including prescription medications, thus suggesting better disease control.

Conclusion

There is conflicting evidence to conclude whether timing of ESS affects disease-specific measures in patients with CRS. Patients who receive surgery earlier appear to have lower demands on healthcare utilization including visits and prescription use. Our study suggests there is a need for increased access to surgical specialists who manage patients with CRS, and better understanding by primary care specialists in how to manage CRS when specialist access is not available.
Imaging of an exceptional urinoma complicating a cervical cancer and leading to death: A case report
Authors: Haidar Ali , Andour Hajar , Essaber Hatim , Abdallah Hussein , El Bakkari Asaad , Allioui Soukaina , Omor Youssef , Latib Rachida
Published: May 2024

Spontaneous urinoma is a rare urological complication that can occur following acute urinary obstruction. It involves a collection of urine that typically forms around the kidney as a result of rupture of the fornix. There are several causes of acute urinary stasis, including lithiasis, tumors, prostatic hypertrophy, and others. We present a unique case of an asymptomatic spontaneous urinoma discovered incidentally during the extension study of a 66-year-old woman with cervical cancer. The positive diagnosis was made through a combination of ultrasound and uro-computed tomography scan. The evolution was marked by the occurrence of a uremic encephalopathy, leading to death before any treatment.
Basal cell carcinomas of the areola-nipple complex: Case report and review of the literature
Authors: Mouadin Amal , Tahiri El Ousrouti Laila , Boukansa Sara , Hammas Nawal , Chbani Laila
Published: May 2024

Basal cell carcinoma of the areola-nipple complex poses diagnostic and therapeutic challenges due to its rarity and unique anatomical location. This subtype of basal cell carcinoma necessitates meticulous management to address potential recurrence and metastasis. Surgical excision with clear margins remains the cornerstone treatment for basal cell carcinoma of the areola-nipple complex, while alternative modalities such as radiation therapy, Mohs surgery, and systemic therapies may be considered in specific cases. However, optimal management strategies remain contentious, with varying opinions on the necessity of aggressive surgical intervention to minimize recurrence and metastasis risks. Additionally, the absence of standardized diagnostic criteria and treatment guidelines complicates clinical decision-making. Herein, we present a rare case of basal cell carcinoma of the areola-nipple complex in a 47-year-old woman with a notable medical history of hypertension, type 2 diabetes, and untreated psychosis, alongside a family history of breast cancer in her aunt. The patient exhibited a non-regressing ulceration on the right areolar region of the breast, persisting for approximately 10 years and progressively extending over time. Following surgical excision, a favorable post-therapeutic course was observed during follow-up. This case underscores the diagnostic challenges and nuanced management considerations inherent in basal cell carcinoma of the areola-nipple complex, underscoring the imperative for tailored treatment approaches.
Postaxial polydactyly of the bilateral hand in toddler: Case report and literature review
Authors: Pradhan Nomina
Published: May 2024

Polydactyly is a common congenital malformation of the hand and foot characterized by an extra digit or duplication of digits. Polydactyly can present as preaxial, complex, or postaxial types. It has various presentations, and it can be an isolated anomaly or part of other diseases or syndromic conditions. Incidences are more common in European and Asian descent. The first line of treatment commonly practiced is surgery to create an aesthetically normal functioning hand. In this report, we present a case of bilateral hand polydactyly in a 2-year 6-month-old boy of Asian descent. No other abnormalities or malformations were observed elsewhere in his body. He is otherwise a healthy boy with no family history of malformations. The pattern is not consistent with any syndromic disease. He subsequently underwent surgical resection of the extra digits and a follow-up review showed normal function of the hands without contracture and other complications of the surgical site.
The Triple Helix Model for Industry-Education City Integration in China: A Development Approach
Authors: Cheng Chen , Cheng Si , Feng Chunsheng
Published: May 2024

Urbanization, vocational education, and industry in China have been influenced by policy and economic changes. This article outlines potential solutions for the integrated development of urbanization, vocational education, and industry in China. By integrating the development ideas of the triple helix model based on international related research literature, this article proposes a development model for China’s industry-education city integration. Taking the Liuzhou rail transit industry-education city as an example, this article adopts a comprehensive and sustainable development approach, including urban management, industry-education integration, and industry innovation and entrepreneurship, centered around the characteristics of urbanization, vocational education, and industry. The development of China’s industry-education city through the triple helix model has brought about innovations in education, industry, urban form, policy, technology, and social culture, which can help China’s urbanization, vocational education, and industry achieve spiral development.
“It’s Your Fault!”—Said the Vaccinated to the Unvaccinated. The Effect of COVID-19 Vaccination on Responsibility Attribution
Authors: Drążkowski Dariusz , Trepanowski Radosław
Published: May 2024

Limited knowledge exists regarding the factors influencing the perceptions of individuals who may have transmitted a contagious virus. This study examined the impact of vaccination status on evaluations of individuals suspected of being sources of infection. The vaccination status of three individuals—the study participant (observer), the potential source of infection (actor), and the infected person—was considered. A total of 395 participants were assigned to one of four conditions based on vaccination status. Results revealed that vaccinated observers attributed greater responsibility for the infection to the unvaccinated actor, perceiving them as less moral, trustworthy, and empathetic compared to unvaccinated observers. The vaccination status of the infected person did not significantly influence observers’ evaluations of the actor, nor did it affect unvaccinated observers’ assessments based on the actor’s vaccination status. These findings suggest that vaccinated individuals may negatively assess unvaccinated individuals suspected of being sources of infection.
What Is a Successful Business Model? Exploration and Measurement of Key Attributes of Business Model
Authors: Zhang Jiayue
Published: May 2024

The attributes of the business model have become an essential factor affecting enterprise performance and competitive advantage. However, there still needs to be systematic identification of key attributes and empirical tests between key attributes and firm performance. To fill the research gap, we conducted a questionnaire and open-ended coding to identify five key attributes of successful business models, and then a measurement scale was developed. The empirical analysis based on 445 samples shows that the measurement scale of multi-dimensional business model attributes composed of novelty, sustainability, efficiency, expandability, and value co-creation has good reliability and validity. Our findings contribute to identifying key attributes of successful business models from different industries and examining the impact of key attributes on firm performance. Furthermore, the conclusion of this study will be an excellent enlightenment to understand better the key attributes of business models and the firm performance advantages brought by them for both research and practice.
Longitudinal Associations Between Competition Contingent Self-Worth and Materialistic Values Among Chinese College Students: A Latent Growth Model
Authors: Yi Cong , Wei Jun , Liu Yanyan , Zheng Minglu
Published: May 2024

This longitudinal study examined how the initial levels and change rates of competition contingent self-worth (CSW) predicted changes in materialistic values among college students during their first two college years. Participants were 948 students (607 females; M age = 18.61, SD age = .71 years, at Wave 1) from eight Chinese universities. Students’ competition CSW was measured annually across three waves, and their materialistic values were assessed at the last two waves. Latent growth analyses showed that Chinese college students generally experienced a mean-level decline in competition CSW from their freshmen to junior year. Students with higher initial levels or slower declining rates (or faster increasing rates) of competition CSW obtained greater increases in materialistic values over time. The results highlighted the potential role of competition CSW in contributing to the development of materialistic values among Chinese college students, which may pose threat to their well-being and comprehensive development in college.
Radiographic Alignment Parameters for Lumbosacral Reconstruction in Patients With Altered S1 Morphology
Authors: Patel Arpan A. , Srivatsa Shaarada , Greenberg Jacob K. , Pelle Dominic W. , Savage Jason W. , Steinmetz Michael P. , Spiessberger Alexander
Published: May 2024

Study Design

Retrospective quantitative analysis study.

Objectives

Pelvic incidence has been established as central radiographic marker which determines patient-specific correction goals during surgery for adult spinal deformity. In cases with sacral doming or sacral osteotomy where the PI cannot be calculated, reliable radiographic parameters need to be established to determine surgical goals. We aim to determine multiple radiographic parameters and formulas that can be utilized when the S1 superior endplate is obscured.

Methods

Retrospective analysis was performed on 68 healthy volunteers without prior spine surgery with full-length radiographs. Pelvic incidence, sacral slope, and pelvic tilt were calculated for each patient. Additional measurements such as L4, L5, and S2 incidence, tilt, and slope were collected. A new radiographic parameter defined as the L4-Sciatic notch angle was measured. Regression analysis was performed on each value to determine its relationship with S1 based incidence, tilt, and slope.

Results

Mean values for L5 incidence, L4 incidence, and L4 sciatic notch angle were 21.8° ± 8.9, 4.4° ± 8.1, and 44.4° ± 12, respectively. The linear regression analysis produced the following formulas which can be utilized to determine deformity correction goals when pelvic incidence can be calculated pre-operatively: L5i = .65*S1i–11.4, L4i = .44*S1i-18.6, and L4SNA = −.34*S1i + 66.5. In settings where pelvic incidence cannot be calculated, the following formulas can be utilized: L5i = .66*S2i-32.3 and L4SNA = −.02*S2i2 + 1.1*S2i + 63.5. P-values for all regression analyses were <.001.

Conclusion

This study provides target radiographic alignment values that can be utilized for patients with either pre-operative altered S1 endplates or in cases with intraoperative alteration of S1 (sacral osteotomy).
The influence of pain presence on pelvic floor and sexual dysfunctions, and pain intensity-related variables in women using the menstrual cup: A cross-sectional survey
Authors: Fuentes-Aparicio Laura , Cuenca-Martínez Ferran , Cortés-Amador Sara , Eroles-Tena Elena , Millán-González Coral , Sempere-Rubio Núria
Published: May 2024

Objective:

The aim was to assess the influence of pain during menstrual cup use on pelvic floor and sexual dysfunctions. In addition, we wanted to assess its impact on variables related to pain intensity during menstrual cup use such as insertion, removal, during menstruation, during sexual intercourse or the presence of pelvic pain.

Methods:

This study was a cross-sectional survey. The study included 566 women who fulfilled the inclusion criteria. Women were categorised into two primary groups: women with no pain and women with pain.

Results:

Regarding pelvic floor dysfunction, the independent samples t-test showed significant between-group differences ( t(564) = −3.50, mean differences (MD) = −8.86 (−13.8 to −3.89), p < 0.001). With respect to sexual dysfunction, no significant between-group differences were found with the exception of the pain subscale ( t(564) = 2.59, MD = 0.27 (0.48–0.06), p = 0.01. Regarding pain-related variables, we found statistically significant between-groups differences on all analysed variables.

Conclusions:

In conclusion, the results showed that women who use the menstrual cup and have pain showed worse scores on the pelvic floor dysfunction questionnaire, where it also seems that greater pain intensity was associated with worse questionnaire scores. However, we found no significant differences in sexual dysfunction except for the pain subscale between women who did and did not report pain in menstrual cup use. Finally, women who reported pain from menstrual cup use showed significantly greater pain intensity when inserting and removing the menstrual cup, during menstruation, during sexual intercourse and showed higher levels of pelvic pain although these differences are clinically slight.
Embodied Injustice: Comparing Lesbian, Bisexual, and Queer and Heterosexual Women’s Accounts of Unwanted Sex
Authors: Ford Jessie V. , Shah Aarushi , Fortuna Gloria , Hirsch Jennifer S.
Published: May 2024

Lesbian, bisexual, and queer (LBQ) women experience disproportionately high rates of unwanted sex, including sexual assault. The literature has noted LBQ women's elevated risk for sexual victimization compared to heterosexual women, but little research has compared LBQ women's processing of sexual violations to those of heterosexual women. To address this gap, this article examines accounts of unwanted sex among 20 LBQ and 38 heterosexual college women (57 cisgender; 1 transwoman). We use both studies of embodiment and queer theory to understand socially patterned differences between LBQ and heterosexual women’s accounts of unwanted sex. Our findings indicate that heterosexual women’s multiple experiences with men (violent and not) often lead to explanations of sexual violations focused on men’s individual characteristics, for example, certain men are better/worse than others. In contrast, LBQ women’s experiences with women/non-binary partners produce a broader critique of heterosexuality. We find suggestive evidence that this difference helps LBQ women move away from self-blame toward a position of naming injustice.
Numerical simulation and entropy optimization of hybrid nanofluid flow in an inclined wavy enclosure subjected to thermal radiation
Authors: Rehman Sadique , Parveen Rujda , Jamshed Wasim , Prakash M , Ibrahim Rabha W , Eid Mohamed R , Hussain Syed M , Ahmad Hijaz
Published: May 2024

The current study investigates two-dimensional natural convective heat transference and entropy production in a tilted wavy-walled enclosure under the magnetic field and thermal radiation effect. The enclosure is filled with Cu–Al2O3/H2O hybrid nanofluid and subjected to a non-uniformly heated curved left wall, constant cold right curved side, uniformly heated bottom side, and insulated upper side. The regulating formulas in the non-dimensional form are reduced to streaming function-velocity expression and are numerically solved based on the Bi-CGStab method. The simulations are behaved with diverse Rayleigh amounts, Hartmann numbers, an incline angle of the enclosure, radiation parameters, diverse amplitude of the curved wall, and volume fraction of hybrid nanoparticles. Numerical code validation with other published results agrees well with the present outcomes. Heat and entropy generation were improved with the change in dimensionless parameters, and the findings have been clarified through discussion. The observations indicate that the Rayleigh numbers, nanoparticle fractional size, amplitude, and radiation parameter influence the convective effect and entropy production inside the enclosure. In contrast, the Hartmann number detracts from the convective effect. The findings suggest that a rise in the cavity angle may result in a corresponding boost or decline in heat transference. The minimum Nusselt numbers is obtained at [Formula: see text], as the angle of incline of the enclosure restraints the fluid rapidity and diminishes the heat transference rates. To design heat exchangers, this particular study may serve as a guide.