bluuebunny/crossref_metadata_2025 huggingface dataset:
Príncipe de Maquiavel: uma sátira em defesa da Liberdade
Authors: De Oliveira Gabriela Antoniello
Published: February 2022

Resumo: O presente artigo apresenta uma análise sobre o principal objetivo de Maquiavel ao redigir sua mais polêmica e principal obra: O Príncipe. Para tal análise analisaremos o contexto histórico-cultural da Itália e mais especificamente o ambiente de Florença no século XVI, cidade e época do nosso filósofo. Pretendo apontar evidências que influenciaram o pensamento de Maquiavel, seu interesse pessoal e os objetivos da obra O Príncipe, tendo como principal alvo de discussão a possibilidade de que ao escrever conselhos para o governante da época, o Lourenço de Médici (posteriormente nomeado Duque de Urbino em 1516), o filósofo não redigiu ensinamentos exclusivos para ele, mas também aos povos, que pela seu método de escrita realista deixou evidentes conteúdos e exemplos de como funciona a política de fato. Em outras palavras, entregou fatos de como realmente agem os governantes e deixou sua teoria maquiaveliana como uma sátira contra a tirania e em defesa da liberdade.
Palavras-chave: Filosofia Política. Maquiavel. Liberdade. Modernidade.
 
Abstract: This article presents an analysis of Machiavelli's main objective in writing his most controversial and main work: The Prince. For this analysis, we will analyze the historical-cultural context of Italy and more specifically the environment of Florence in the 16th century, the city and time of our philosopher. I intend to point out evidences that reflect Machiavelli's thought, his personal interest and the objectives of the work O Principe, having as main subject of discussion the possibility that when writing advice for the ruler of the time, Lourenço de Médici (revised Duque de Urbino in 1516), the philosopher did not write exclusive teachings for him, but also for the peoples, who by his method of realistic writing contains evident and examples of how politics actually works. In other words, the words delivered facts of how the rulers really act and left their Machiavelli theory as a satire against tyranny and in defense of freedom.
Keywords: Political philosophy. Machiavelli. Freedom. Modernity.
Abraão e Maria:
Authors: Santos Antonio Macedo dos
Published: February 2022

Resumo: Dentre os vários personagens que Søren Aabye Kierkegaard (1813-1855) inscreve em Temor e tremor, Abraão, protagonista, e Maria são os que vivem na dramaticidade da fé. O artigo toma tais personagens como objeto de estudo, com o objetivo de analisar as figuras destes com vistas à compreensão sobre qual função eles cumprem na trama da obra. Para isso, embasa-se em fontes teológico-exegéticas e filosóficas, caracterizando uma metodologia pautada em revisões bibliográficas. Tomando os personagens a partir de tais fontes, os resultados apontam que é possível distinguir tradições que permitem maior compreensão de suas vivências de fato e das vivências que se diz que tiveram. Conclui-se que Abraão e Maria, mais que provas vivas do conceito de fé, de suspensão teleológica da ética, etc., são referências para compreender tais conceitos.
Palavras-chave: Ética; Suspensão; Abraão; Maria; Fé.
Abramo e Maria: personaggi di riferimento dei concetti di Kierkegaard in Timore e Tremore
Sintesi: Fra i tanti personaggi che Søren Aabye Kierkegaard (1813-1855) arrola all’iterno di Timore e tremore Abramo, il protagonista, e Maria sono quelli che vivono nella drammaticità della fede. L’articolo ha come fuoco di studio tali personaggi. Così, l’obbiettivo è fare un’analisi delle figure di Abramo e Maria com fuoco alla comprensione di quale funzione loro compiono nella tramma di Timore e tremore. Per tanto, l’articolo si basa su fonti teologiche, esegetiche e filosofiche, dunque si ha una metodologia di revisione bibliografica. I risultati indicano che havendo preso i personaggi partendo di fonti teologiche e esegetiche è possibile individuare tradizioni che permettono una più ampia comprensione delle sue reali vicende e delle vicende che si disse ebbero havuto. Insomma, Abramo e Maria, più che prove viventi del concetto di fede, di suspensione teleologica dell’etica, ecc. sono riferimenti per compreendere tali concetti. 
Parole-chiavi: Etica; Suspensione; Abramo; Maria; Fede.
Data de registro: 05/09/2021
Data de aceite: 25/11/2021
Educação e Filosofia: uma leitura a partir de Freud e Benjamin
Authors: Schlesener Anita Helena
Published: February 2022

Resumo: O presente artigo tem o objetivo de tecer algumas considerações sobre as concepções de mundo que formam nosso imaginário a partir de uma leitura de Freud e de Benjamin. Este aporte teórico permite entender a dimensão ideológica de ideias e preconceitos que sedimentam o senso comum e que consolidam relações de dependência. A educação, entendida como processo de formação que acontece na vida, se alimenta da filosofia mesmo inconscientemente e as relações sociais e políticas orientam a formação da subjetividade individual. Benjamin explicita estas relações ao analisar as imagens oníricas cotejando os conceitos de sonho e despertar com o objetivo de mostrar a importância de conhecer o passado e elaborar uma história materialista da cultura, como tarefa básica para pensar o futuro.Palavras chaves: Educação. Filosofia. Imagens oníricas. Ideologia.

Education and philosophy: a reading from Freud and Benjamin

Abstract: This article aims to weave some considerations about the conceptions of the world that form our imaginary from a reading of Freud and Benjamin. This theoretical contribution allows us to understand the ideological dimension of ideas and prejudices that sediment common sense and consolidate relationships of dependence. Education, understood as a process of formation that happens in life, feeds on philosophy even unconsciously, and social and political relations guide the formation of individual subjectivity. Benjamin explains these relationships by analyzing the dream-images by comparing the concepts of dream and awakening with the purpose of showing the importance of knowing the past to elaborate a materialistic history of culture as a basic task to think about the future.Key words: Education. Philosophy. Dream images. Ideology.

Educazione e filosofia: una lettura di Freud e Benjamin

Riassunto: Questo articolo ha l’obiettivo di fare alcune riflessioni sulle concezioni del mondo che formano il nostro immaginario da una lettura di Freud e Benjamin. Questa base teorica ci consente di comprendere la dimensione ideologica delle idee e dei pregiudizi che basano il senso comune e rinsaldano le relazioni di dipendenza. L'istruzione, intesa come un processo di formazione che accade nella vita, si nutre anche inconsciamente della filosofia e le relazioni sociali e politiche guidano la formazione della soggettività individuale. Benjamin spiega queste relazioni analizzando le immagini dei sogni riunendo i concetti di sogno e risveglio al fine di dimostrare l'importanza di conoscere il passato ed elaborare una storia materialista della cultura, come compito fondamentale per pensare al futuro.Parole chiave: Educazione. Filosofia. Immagini dei sogni. Ideologia.

Data de registro: 09/09/2019

Data de aceite: 16/06/2020
School funding in Australia: A critical policy analysis of school sector influence in the processes of policy production
Authors: Sinclair Matthew P. , Brooks Jeffrey S.
Published: February 2022

The distribution of government funding for schooling can lead to significant differences in educational opportunities and outcomes for students. Unsurprisingly, school funding policy has been a site of intense political and public debate in many countries. In Australia, the Public, Catholic, and Independent school sectors, which collectively make up the Australian education system, all receive government funding. This article examines the representation and influence of the three school sectors at key moments in the policymaking cycle of the Review of Funding for Schooling, a pivotal 2011 report that shaped the trajectory of school funding policy in Australia. This case study focused on the report's development and found a disproportional representation of the Independent and Catholic school sectors at key points in the Review's policy cycle. In light of this critique, the article includes recommendations for more equitable policymaking processes in the future.
Correlation between CYP2C9 gene polymorphism and warfarin dose in Chinese Han population with coronary heart disease
Authors: Zuo Qiyu , Li Li , Zhong Mingjing , Chen Gengbiao , Xio Junhui
Published: February 2022

This study aimed to explore the correlation between CYP2C9 gene polymorphism and warfarin dose in Chinese Han patients with coronary heart disease. The selection was made to the analysis of blood coagulation test of Chinese Han ethnic group, 200 cases of coronary heart disease patients as target group, the patients were satisfied taking warfarin INR target (in the range of 2.0 ~ 3.0), the other to select 200 cases proved by physical examination health as health group. The warfarin dose and the clinical laboratory INR after warfarin administration were taken, and the DNA of the patients was extracted and tested. The CYP2C9 genotype and allele frequency of patients in the standard group were observed, and the basic information and gene test results of the healthy group and the standard group were compared. Patients in the standard group were grouped according to the CYP2C9 and VKORC1 genotype, and the warfarin dosage was compared respectively. The number of cases of anticoagulant overdose in patients with different genotypes in the target group at the initial stage of warfarin treatment was compared. Results showed that CYP2C9*1/*2, *2/*2, *2/*3, *3/*3 genotypes were not found by detecting CYP2C9 genotype and allele frequency in the standard group. There were no significant differences in genotype and allele frequency between the standard group and the healthy group (P BBB 0 0.05). The mean daily dose of the CYP2C9*1/*3 genotype was lower than the mean daily dose of warfarin required by the CYP2C9*1/*1 genotype, and the difference was statistically significant (P < 0.05). There were significant differences in the incidence of anticoagulation overdose at the initial stage of treatment among different CYP2C9 genotypes (P < 0.05), and the incidence of an anticoagulation overdose in group *1/*3 was significantly higher than that in group *1/*1. In general, There was a correlation between CYP2C9 gene polymorphism and warfarin dose in Chinese Han population with coronary heart disease. Compared with the wilD-type (*1/*1) enzyme, the metabolic ability of warfarin in mutant CYP2C9 enzyme (mainly *1/*3 in Chinese population) decreases, and the patients were sensitive to warfarin treatment, and the dose required decreases.
Bibliotheksdienste in dezentralen Websuchsystemen
Authors: Kubek Mario
Published: February 2022

Stellt man sich das World Wide Web als riesige Bibliothek vor, bräuchte es einen Bibliothekar oder zumindest Dienste, die die vielfältigen Aufgaben dieser Person in vergleichbarer Weise und Qualität erfüllen können. Aktuelle Websuchmaschinen können diese Aufgaben wie die Katalogisierung von Publikationen sowie die Vermittlung zwischen bibliothekarischen Ressourcen und Nutzern nicht einmal annähernd zufriedenstellend erfüllen. Daher können Bibliothekare insbesondere bei langfristigen und tiefgehenden Recherchen eine viel bessere Unterstützung bieten. Dieser Artikel diskutiert die vielen Vorteile der Dienstleistungen von Bibliotheken und Bibliothekaren und erläutert, wie diese in neuartigen und dezentral organisierten Websuchsystemen realisiert werden können, um Nutzer bei Forschungsaufgaben nachhaltig zu unterstützen.
Sources of Finite Speed Temperature Propagation
Authors: Mariano Paolo Maria , Spadini Marco
Published: February 2022

The relation between heat flux and temperature gradient has been considered as a constitutive structure or as a balance law in different approaches. Both views may allow a description of heat conduction characterized by finite speed propagation of temperature disturbances. Such a result, which overcomes Fourier’s drawback of infinite speed propagation, can be obtained also by considering insufficient the representation of a conductor, even when it is considered to be rigid, rather than the sole relation between heat flux and temperature gradient. We comment this last view and describe the intersection with previous proposals. Eventually, we show how under Fourier’s law we can have traveling-wave-type temperature propagation when thermal microstructures are accounted for.
Robust estimation for partial functional linear regression models based on FPCA and weighted composite quantile regression
Authors: Cao Peng , Sun Jun
Published: February 2022

In this paper, we consider a novel estimation for partial functional linear regression models. The functional principal component analysis method is employed to estimate the slope function and the functional predictive variable, respectively. An efficient estimation based on principal component basis function approximation is used for minimizing the proposed weighted composite quantile regression (WCQR) objective function. Since the proposed WCQR involves a vector of weights, we develop a computational strategy for data-driven selection of the optimal weights. Under some mild conditions, the theoretical properties of the proposed WCQR method are obtained. The simulation study and a real data analysis are provided to illustrate the numerical performance of the resulting estimators.
Oscillatory hyper-Hilbert transform on Wiener amalgam spaces
Authors: Sun Wei , Xie Ru-Long , Xu Liang-Yu
Published: February 2022

We study the boundedness of the oscillatory integral

T

α
,
β

f

(

x
,
y

)

=

∫

Q

2

f

(

x
−

γ

1

(

t

)

,
y
−

γ

2

(

s

)

)

e

−
2
π
i

t

−

β

1

s

−

β

2

t

−
α

1

−
1

s

−

α

2

−
1

d
t
d
s

{T}_{\alpha ,\beta }f\left(x,y)=\mathop{\int }\limits_{{Q}^{2}}f\left(x-{\gamma }_{1}\left(t),y-{\gamma }_{2}\left(s)){e}^{-2\pi i{t}^{-{\beta }_{1}}{s}^{-{\beta }_{2}}}{t}^{{-\alpha }_{1}-1}{s}^{-{\alpha }_{2}-1}{\rm{d}}t{\rm{d}}s

on Wiener amalgam spaces, where

Q

2

=

[

0
,
1

]

×

[

0
,
1

]

{Q}^{2}=\left[0,1]\times \left[0,1]

is the unit square in two dimensions,

(

x
,
y

)

∈

R

n

×

R

m

,

γ

1

(

t

)

=

(

t

p

1

,

t

p

2

,

…

,

t

p

n

)

,

γ

2

(

s

)

=

(

s

q

1

,

s

q

2

,

…

,

s

q

m

)

\left(x,y)\in {{\mathbb{R}}}^{n}\times {{\mathbb{R}}}^{m},{\gamma }_{1}\left(t)=\left({t}^{{p}_{1}},{t}^{{p}_{2}},\ldots ,{t}^{{p}_{n}}),{\gamma }_{2}\left(s)=\left({s}^{{q}_{1}},{s}^{{q}_{2}},\ldots ,{s}^{{q}_{m}})

are homogeneous curves on

R

n

{{\mathbb{R}}}^{n}

and

R

m

{{\mathbb{R}}}^{m}

.
Degenerate binomial and Poisson random variables associated with degenerate Lah-Bell polynomials
Authors: Kim Taekyun , Kim Dae San , Dolgy Dmitry V. , Park Jin-Woo
Published: February 2022

The aim of this paper is to study the Poisson random variables in relation to the Lah-Bell polynomials and the degenerate binomial and degenerate Poisson random variables in connection with the degenerate Lah-Bell polynomials. Among other things, we show that the rising factorial moments of the degenerate Poisson random variable with parameter

α

\alpha

are given by the degenerate Lah-Bell polynomials evaluated at

α

\alpha

. We also show that the probability-generating function of the degenerate Poisson random variable is equal to the generating function of the degenerate Lah-Bell polynomials. Also, we show similar results for the Poisson random variables. Here the

n

n

th Lah-Bell number counts the number of ways a set of

n

n

elements can be partitioned into non-empty linearly ordered subsets, the Lah-Bell polynomials are natural extensions of the Lah-Bell numbers and the degenerate Lah-Bell polynomials are degenerate versions of the Lah-Bell polynomials.
On the mixed fractional quantum and Hadamard derivatives for impulsive boundary value problems
Authors: Niyoom Somboon , Ntouyas Sotiris K. , Sudprasert Chayapat , Tariboon Jessada
Published: February 2022

In this work, we initiate the study of a new class of impulsive boundary value problems consisting of mixed type fractional quantum and Hadamard derivatives. We will establish existence and uniqueness results by using tools from the functional analysis. We prove the uniqueness result via Banach’s contraction mapping principle, while we will use the Leray-Schauder nonlinear alternative to establish an existence result. We also present examples to illustrate the obtained results.
Nuclear radiation detection based on the convolutional neural network under public surveillance scenarios
Authors: Yan Zhangfa , Zhang Zhaohui , Xu Shuyu , Ma Juxiang , Hou Yansong , Ji Yingcai , Sun Lifeng , Dai Tiantian , Wei Qingyang
Published: February 2022

Nuclear energy is a clean and popular form of energy, but leakage and loss of nuclear material pose a threat to public safety. Radiation detection in public spaces is a key part of nuclear security. Common security cameras equipped with complementary metal oxide semiconductor (CMOS) sensors can help with radiation detection. Previous work with these cameras, however, required slow, complex frame-by-frame processing. Building on the previous work, we propose a nuclear radiation detection method using convolution neural networks (CNNs). This method detects nuclear radiation in changing images with much less computational complexity. Using actual video images captured in the presence of a common Tc-99m radioactive source, we construct training and testing sets. After training the CNN and processing our test set, the experimental results show the high performance and effectiveness of our method.
Elfolyó és elfogyó vizeink nyomában?
Authors: András Burján
Published: February 2022

Kákai László és Glied Viktor hiánypótló kötete napjaink különösen aktuális témáját kutatja és tárja fel az érdeklődő olvasók számára az egyes tanulmányokon keresztül. A mű témája döntően a globális klímaváltozás valós problémája, ami egyre inkább életünk velejárójává válik. Ennek megfelelően tárgyalja a könyv, hogy a klímaváltozás káros környezeti és természeti hatásainak enyhítése, a negatív folyamatok megállítása, a következmények elhárítása, a megoldandó kérdésekre adandó optimális válaszok megtalálása mára mindannyiunk közös ügye és felelőssége. Az „Elfolyó és elfogyó vizeink nyomában - Vízproblémák Közép Európában és a Balkánon” című kötet 2021. novemberében a Pécsi Tudományegyetem BTK Politikatudományi és Nemzetközi Tanulmányok Tanszékének kiadásában jelent meg. Az összefoglaló kötet nyolc különálló tanulmányt tartalmaz, amelyek mindegyike a víz funkciójával, minőségével és mennyiségével összefüggő kihívásokat és az ezekre adandó megoldásokat kutatják. A nyolc elemzés szerteágazó, széles spektrumú képet nyújt a témában az olvasó számára.
Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma
Authors: Kauer Sierra D. , Fink Kathryn L. , Li Elizabeth H. F. , Evans Brian P. , Golan Noa , Cafferty William B. J.
Published: February 2022

Failure of CNS neurons to mount a significant growth response after trauma contributes to chronic functional deficits after spinal cord injury. Activator and repressor screening of embryonic cortical neurons and retinal ganglion cellsin vitroand transcriptional profiling of developing CNS neurons harvestedin vivohave identified several candidates that stimulate robust axon growthin vitroandin vivo. Building on these studies, we sought to identify novel axon growth activators induced in the complex adult CNS environmentin vivo. We transcriptionally profiled intact sprouting adult corticospinal neurons (CSNs) after contralateral pyramidotomy (PyX) in nogo receptor-1 knock-out mice and found that intact CSNs were enriched in genes in the 3-phosphoinositide degradation pathway, including six 5-phosphatases. We explored whether inositol polyphosphate-5-phosphatase K (Inpp5k) could enhance corticospinal tract (CST) axon growth in preclinical models of acute and chronic CNS trauma. Overexpression ofInpp5kin intact adult CSNs in male and female mice enhanced the sprouting of intact CST terminals after PyX and cortical stroke and sprouting of CST axons after acute and chronic severe thoracic spinal contusion. We show thatInpp5kstimulates axon growth in part by elevating the density of active cofilin in labile growth cones, thus stimulating actin polymerization and enhancing microtubule protrusion into distal filopodia. We identifyInpp5kas a novel CST growth activator capable of driving compensatory axon growth in multiple complex CNS injury environments and underscores the veracity of usingin vivotranscriptional screening to identify the next generation of cell-autonomous factors capable of repairing the damaged CNS.

SIGNIFICANCE STATEMENTNeurologic recovery is limited after spinal cord injury as CNS neurons are incapable of self-repair post-trauma.In vitroscreening strategies exploit the intrinsically high growth capacity of embryonic CNS neurons to identify novel axon growth activators. While promising candidates have been shown to stimulate axon growthin vivo, concomitant functional recovery remains incomplete. We identifiedInpp5kas a novel axon growth activator using transcriptional profiling of intact adult corticospinal tract (CST) neurons that had initiated a growth response after pyramidotomy in plasticity sensitized nogo receptor-1-null mice. Here, we show thatInpp5koverexpression can stimulate CST axon growth after pyramidotomy, stroke, and acute and chronic contusion injuries. These data supportin vivoscreening approaches to identify novel axon growth activators.
An Auto-Ethnographic Entrée en Matière and Mise en Contexte
Authors: Hernandez Analays Alvarez
Published: February 2022

This Dialogues section seeks to contribute to the scholarship on Latin American art in Canada and “Latinx Canadian art.” We aim to broaden the historical and current narratives of art and artists from Latin America north of the United States, taking into account Canada’s history of migration and its official bilingual status (French-English), multilingual and multicultural reality, and relationship with Indigenous peoples. Adding to the urgency of studying the presence of Latin American art in Canada, there is also a need to focus on the work of artists and curators with a Latin American background. They are developing languages of expression, practices, and aesthetics that no longer conform to the “Latin American art” category. It is thus essential to highlight the multiple artistic initiatives that are allowing them to gain visibility and recognition within both the local and global artistic milieus. We posit that today it is almost impossible to overlook both the historical and the ongoing presence of Latin American art and artists in Canada and the recent emergence of a vibrant, ever-expanding contemporary Latinx Canadian art scene. This section proposes six groundbreaking contributions that, from coast to coast, offer further data and analysis, case studies, and investigations into museum archives: from Vancouver to Montréal, from pre-Columbian art and material culture to contemporary art, from the Chilean diaspora of the 1970s to more recent migration waves, from curatorial strategies to the classroom.
Sur Gallery
Authors: Toledo Tamara
Published: February 2022

This Dialogues section seeks to contribute to the scholarship on Latin American art in Canada and “Latinx Canadian art.” We aim to broaden the historical and current narratives of art and artists from Latin America north of the United States, taking into account Canada’s history of migration and its official bilingual status (French-English), multilingual and multicultural reality, and relationship with Indigenous peoples. Adding to the urgency of studying the presence of Latin American art in Canada, there is also a need to focus on the work of artists and curators with a Latin American background. They are developing languages of expression, practices, and aesthetics that no longer conform to the “Latin American art” category. It is thus essential to highlight the multiple artistic initiatives that are allowing them to gain visibility and recognition within both the local and global artistic milieus. We posit that today it is almost impossible to overlook both the historical and the ongoing presence of Latin American art and artists in Canada and the recent emergence of a vibrant, ever-expanding contemporary Latinx Canadian art scene. This section proposes six groundbreaking contributions that, from coast to coast, offer further data and analysis, case studies, and investigations into museum archives: from Vancouver to Montréal, from pre-Columbian art and material culture to contemporary art, from the Chilean diaspora of the 1970s to more recent migration waves, from curatorial strategies to the classroom.
The Once and Future Histories of the Book
Authors: Loic Erika
Published: February 2022

Contemporary Latin American and Latinx artists who engage with pre-Hispanic and early colonial book histories have adapted the materials, formats, or iconographies of sixteenth- and seventeenth-century books and objects of knowledge transfer. Although the resulting artworks are as wildly varied as the idea of the book itself, they constitute forms of decolonial praxis in their desire to reclaim or reassign agency in historical narratives; uncover, criticize, or dismantle structures of inequity; or preserve, re-create, and cocreate knowledge. Artists’ remixes and renewals are not derivative or motivated by a simple desire to preserve the past. Some have reclaimed pre-Hispanic techniques to tell new stories, or they have reimagined the book altogether, abandoning its conventional structures and transmuting pre- and postconquest iconographies into murals, sculpture, film, or more conceptual/hybrid works. Contemporary artists have also looked to early colonial books as windows into Indigenous experiences of the conquest, amplifying those perspectives while relating them to recent sociopolitical realities and their hopes for the future. The artists discussed in this essay include Mariana Castillo Deball (Mexico), Sandy Rodriguez (United States), Carlos Colín (Mexico), Estefanía Peñafiel Loaiza (Ecuador), Falco (Ecuador), Andrés Pereira Paz (Bolivia), and Cecilia Vicuña (Chile).
The Notion of “Worker” for the Purpose of EU Social Policy and its Interpretation by the Court of Justice of the European Union
Authors: Komendová Jana , Horecký Jan
Published: February 2022

Social policy is one of the EU policies shared by the EU and the Member States. The aims of EU rules in the field of social policy include protection of the working conditions of workers, on the one hand, and prevention of social dumping between undertakings from different Member States on the other hand. The EU primary and secondary law relating to social policy uses the term “worker.” However, contrary to the national laws of the Member States, there is no definition or explanation of this concept. National laws of Member States provide different definitions of the term “worker” or “employee” which can lead to different levels of protection for workers under the national legislations of EU Member States. For this reason, the concept of “worker” for the purpose of EU social policy may not be interpreted differently according to the law of Member States but has an autonomous meaning specific to EU law.
The Evolution of the Notion of Disability in EU and Polish Labor Law
Authors: Skóra Michał
Published: February 2022

This article analyses the notion of disability in Polish and EU labor law. In the first part of the study, the author characterizes the evolution of this notion based on the interpretation made by the Court of Justice of the European Union. The second part presents the process of development of the definition of disability in Polish law: from disability to the concept contained in the Act on Social and Vocational Rehabilitation and Employment of Persons with Disabilities, and the vocational rehabilitation and employment of disabled people.
Determination and quantitation of benzofuran, Indole and piperazine containing selective serotonin reuptake inhibitor vilazodone hydrochloride in human plasma by LC-ESI-MS/MS with an application to pharmacokinetic study under the frame work of bioequivalence study
Authors: Ghosh Balaram , Mandal Pallab , Chakraborty Soumya , Bera Rakesh , Saha Chiranjit , Poddar Sourav , Barma Sujata , Khanam Jasmina , Karmakar Sanmoy , Pal Tapan Kumar
Published: February 2022

Aim and objectives: Among the various SSRI and 5-HT-1A, partial agonist vilazodone is one of them. It has antidepressant and anti-anxiety activities. This method's main aim and the objective was to develop and validate a bio-analytical method of Vilazodone in human plasma by LC-MS/MS (API-4000) and its application to estimate pharmacokinetics. Method: For reporting this investigation, Analyst software, 1.6.3 used. The mobile phase was acetonitrile with 0.1% formic acid as an organic solvent and Milli Q water with 10Mm ammonium acetate and 0.1% formic acid using the gradation method 7.0min run time. The calibration standard concentrations were 1.0 to 64 ng/ml. Plasma precipitation was by protein precipitation technique. Result: The accuracy of calibration concentrations of Vilazodone was 93.5-104.39% and stability study showed 96.41-106.71%, 94.77-96.36%, 92.22-101.38%, 94.15-98.47%, 93.95-95.75% remaining for freeze-thaw, short term, long term, benchtop and autosampler stability respectively. Recovery was to be 98.10-98.99%; the matrix factor was 0.94-0.96. The maximum plasma concentration of reference preparation was 13.445±2.842ng/ml (Cmax) at a time 6.792±0.846hr. (Tmax). The maximum plasma concentration of test preparation was 13.218±3.231ng/ml (Cmax) at a time 6.958±0.793hr (Tmax) The relative bioavailability of the test preparation was to be 94.66 % of that of the reference preparation. Conclusion: The present investigation was highly selective, sensitive, reproducible, low matrix effect, high recovery and low time-consuming method. It was validated as per USFDA and EMA guideline and successfully used in comparative pharmacokinetics.
Experimental laboratory complex for studying the physical properties of artificially formed gas-hydrate-containing sediments
Authors: KOBOLEV V.P. , MIKHAILYUK S.F. , SAFRONOV A.M.
Published: February 2022

Physical properties of gas hydrate-containing sediments (HCS) are extremely important information for the development of methods for their search and exploration. The presence of gas hydrates in marine bottom sediments significantly changes their physical properties, so they can be detected by marine remote geophysical observations. The physical properties of HCS are very important for detecting the presence of these compounds, estimating the amount of captured gas hydrates by sediments, as well as developing methods for using this resource. Currently, the study of physical properties concerned mainly artificial gas hydrates in the process of formation and decomposition under various thermodynamic conditions in their pure form. Therefore, very little is known about the physical properties of HCS, which makes their detection by remote geophysical surveys too difficult. Development and creation of experimental laboratory modular complex for formation of artificial methane gas hydrates in various lithological-granulometric matrices (sandstones, argillites, siltstones, etc.) and measurement of their physical properties in thermodynamic conditions of bottom sediments of the Black Sea, will increase efficiency technology of methane hydrate deposits development. Under experimental conditions, along with the thermal conductivity and velocities of longitudinal and transverse waves of artificial HCS, the parameters of elastic deformation, strength, and decay characteristics will be measured, which will allow performing theoretical analysis to build models based on different hypotheses of their genesis. At the S.I. Subbotin Institute of Geophysics of the National Academy of Sciences of Ukraine created a model of the installation for the formation and study of the physical properties of HCS. The development is based on the modern technological level of research in the field of thermobaric petro- physical experimental modeling of geological environments, as well as on the use of modern software and hardware laboratory research to obtain physical properties of bottom sediments of various lithological and particle size distribution.
The Impact of Pharmacists’ Interventions to Prevent Medication Errors at a Tertiary Hospital in Central Jakarta, Indonesia
Authors: Azrifitria Azrifitria , Fauziyah Siti , Nur Apriliana
Published: February 2022

To promote the safety and quality of pharmaceutical services are still an issue in Indonesia. One way of doing so is to implement pharmaceutical care standards and prevent medication errors. The aim of this study was to evaluate if the intervention that conducts before and after the socialization in the standard of pharmacy service could cause a decrease in medication errors. The study was conducted by using a quasi-experimental design without a control group in outpatient pharmacy services of a tertiary hospital in central Jakarta, Indonesia. A total of 7627 prescriptions were collected prospectively by the total sampling method in April and May 2016. The observation was conducted in two stages of prescribing and dispensing. A total of 2541 medication errors identified, error rates of 16%  and 33.3%  were found during the prescribing and dispensing stages before socialization (April 2016), respectively. After the socialization in May 2016, the error rates of 15.2% and 20.2% were found in the prescribing and dispensing stages, respectively. However, the differences pre- and post-socialization were not significant (p>0.05). The greatest decrease in medication error was found on drug labels, which fell from 721(21%) to 458 (11%). Observations on near-miss events based on a risk matrix showed that these were dominated by a low-degree of risk. Based on these results, it could be concluded that the intervention given to pharmacists could decline medication errors. Nevertheless, further study with a greater amount of time and better pharmacist socialization is required.
Deskripsi Komponen Major Metabolit Sekunder Tanaman dengan Khasiatnya Terhadap Organ Ginjal dalam Buku Al-qanun fi’l Tibb II
Authors: Agustiani Tri Yuliana , Betha Ofa Suzanti , Dhilasari Estu Mahanani
Published: February 2022

Al-Qanun Fi’l Tibb II merupakan buku karya ilmuwan Islam yaitu Ibnu Sina yang digunakan sebagai pedoman pengobatan pada zaman keemasan islam. Penelitian ini bertujuan untuk memberikan informasi data komponen major tanaman yang berkhasiat terhadap organ ginjal dan mendeskripsikan hubungan antara komponen major metabolit sekunder tanaman dengan khasiatnya terhadap organ ginjal sesuai buku Al-Qanun Fi’l Tibb II. Penelitian dilakukan secara kualitatif dengan metode literature review melalui studi kepustakaan dan diperoleh 250 jurnal ilmiah. Hasilnya dari 44 tanaman yang berkhasiat terhadap organ ginjal terdapat senyawa metabolit sekunder terpen, flavonoid, asam fenolik, alkaloid dan tanin. Senyawa terpen merupakan metabolit sekunder terbanyak pada tanaman. Komponen major metabolit sekunder memiliki bioaktivitas terhadap organ ginjal seperti antioksidan, diuretik, anti-inflamasi, nefroprotektif, antilitiatik dan analgesik
Gambaran Karakteristik Pasien dan Penggunaan Obat Dispepsia Di Klinik A Daerah Bekasi Timur
Authors: Suri Intan , Marvel Marvel , Nurmeilis Nurmeilis
Published: February 2022

Perubahan gaya hidup dan pola makan menjadi salah satu penyebab terjadinya gangguan saluran pencernaan. Gangguan pencernaan yang paling banyak diderita adalah dispepsia. Dalam hal ini banyak faktor risiko yang menyebabkan terjadinya kekambuhan dispepsia. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik pasien dan penggunaan obat dispepsia di klinik A daerah Bekasi Timur. Penelitian ini dilakukan dengan metode cross sectional dengan metode pengambilan data secara retrospektif melalui rekam medik pasien. Pemilihan sampel dengan menggunakan teknik total sampling dimana terdapat 200 sampel yang memenuhi kriteria inklusi dalam penelitian. Hasil penelitian menunjukkan Karakteristik pasien dispepsia di Klinik A Daerah Bekasi Timur yang dominan adalah berjenis kelamin perempuan (60%), berada pada rentang umur ≥ 56 tahun (27,5%), tanpa ada penyakit penyerta (76,5%), jenis penyakit penyerta hipertensi (46,42%), frekuensi kedatangan pasien 1 kali (64,5%), dan penggunaan obat dispepsia dengan 3 kombinasi (57%). Dari hasil uji statistik dihasilkan pernyataan bahwa jenis kelamin, umur tidak mempunyai hubungan yang bermakna dengan frekuensi dispepsia (p > 0,05). Penyakit penyerta mempunyai hubungan yang bermakna dengan frekuensi dispepsia (p < 0,05). Jenis kelamin, umur, penyakit penyerta tidak mempunyai hubungan yang bermakna dengan penggunaan obat dispepsia (p > 0,05). Frekuensi dispepsia mempunyai hubungan yang bermakna dengan obat dispepsia (p < 0,05).
Pengukuran Aktivitas Antioksidan Ekstrak 70% dan 96% Buah Parijoto Asal Bandungan Menggunakan Metode FRAP dan Profil Kromatografinya
Authors: Luhurningtyas Fania Putri , Surya Ranu Putra Adi
Published: February 2022

Abstrak: Buah Parijoto (Medinilla speciosa B.) mengandung senyawa aktif flavonoid yang memiliki aktivitas biologis sebagai antioksidan. Senyawa tersebut dapat diperoleh dengan mengoptimalkan kandungannya pada ekstraksi dengan konsentrasi pelarut yang berbeda. Penelitian ini bertujuan untuk menganalisis aktivitas antioksidan pada ekstrak buah parijoto dengan perbedaan konsentrasi pelarut etanol.  Penelitian dimulai dari tahapan ekstraksi dengan metode maserasi dengan pelarut pelarut etanol 70% dan 96%. Uji fitokimia menggunakan fase gerak n-heksana:etil asetat (8:2). Uji aktivitas antioksidan dengan metode FRAP ( Ferric Reducing Antioxidant Power) dan parameter uji berdasarkan nilai IC50. Hasil penelitian identifikasi metabolit sekunder, menunjukkan positif mengandung flavonoid (bercak biru muda) dan antosianin (bercak merah). Nilai IC50 ekstrak buah Parijoto denga pelarut etanol 70% dan 96% berturut-turut yaitu sebesar 35,46 ppm dan 40,17 ppm. Simpulan dalam penelitian ini adalah ekstrak buah parijoto dengan pelarut etanol 70% mempunyai aktivitas antioksidan lebih bagus dibandingkan ekstrak etanol 96%.
Exclusión social, pandemia y políticas sociales en España: un análisis desde el Trabajo Social
Authors: Morcillo - Martinez Juana Maria
Published: February 2022

Este artículo de investigación ofrece un marco de reflexión analítico, desde el trabajo social, sobre las medidas puestas en marcha para frenar el impacto de la pandemia en España. Partimos de la situación previa a su llegada, evaluamos su incidencia y examinamos sus efectos. Los resultados señalan que las políticas sociales que se apliquen para mejorar las condiciones socioeconómicas y sanitarias de la población ejercen un papel determinante. En este sentido, es fundamental reconocer el esfuerzo del colectivo de trabajadores sociales que desempeñan su praxis profesional con la finalidad de conseguir el empoderamiento de la población española en tiempos de pandemia.
Mechanical properties of stem and physiological–biochemical responses of cucumber under different N and K conditions
Authors: Liu Yong , Wang Yafei , Ma Guoxin , Wang Bin , Du Xiaoxue , Shi Qiang , Ni Jiheng , Mao Hanping
Published: February 2022

In order to investigate the effects of N and K on the mechanical properties of cucumber stems, the physiological and biochemical indexes under different N and K conditions were compared. The analysis showed that the pho-tosynthetic rate was affected by both stress and the self-senescence of cucumber plants, and that the crops under N and K stress were stimulated to activate a highly effective antioxidant system to cope with the damage. Sugar, as the basis for the synthesis and structure formation of the stems, was highly related to stem strength, and polyphenol oxidase in the study of stem strength was limited but indispensable. Compared with CK, the epidermal penetration strength under LN, LNLK, and LNHK treatments increased by at least 10%, while the strength under HN, LK, HNLK, and HNHK treatments decreased by at least 7%. To sum up, it was the photosynthesis rate, the sucrose transportation, as well as the futile cycling of K+ that were the keys of stem strength.
Editorial
Authors: Torres Vivian Gregori
Published: February 2022

.
Da sobrecarga de trabalho ao desemprego: os impactos da pandemia sobre a mulher que trabalha
Authors: Jorge Camila , Saliba Graciane Rafisa , Da Fonseca Bárbara Guimarães
Published: February 2022

A desigualdade entre os gêneros sempre existiu, a dinâmica social leva a uma constante análise pela busca de critérios mais justos e isonômicos de distribuição, entre os sexos, das várias esferas da vida em sociedade, especialmente no âmbito laboral. As normas trabalhistas atuais que visam a proteção da mulher no mercado de trabalho focam, especialmente, no estado gravídico, ou seja, têm como fundamento a gravidez e a proteção do nascituro. Contudo, ao tentar proteger as mulheres, tais normas acabam acarretando, sob a ótica dos empregadores, uma maior onerosidade, o que, muitas vezes, dificulta o acesso ao mercado de trabalho, levando as empresas a optarem por profissionais homens. Não basta que a legislação seja cumprida, é preciso que tais normas sejam estendidas aos homens, igualando os direitos e as oportunidades entre os gêneros. E, ainda, a pandemia causada pelo Coronavírus será um dos eixos centrais no presente artigo, sendo analisados os principais impactos que este contexto trouxe às relações de emprego das mulheres. No que tange ao procedimento metodológico, optou-se pelo método hipotético-dedutivo, haja vista partir-se de uma concepção macro para uma concepção microanalítica, permitindo-se, portanto, a delimitação do problema teórico, com uma pesquisa teórico-bibliográfica.
A cultura de culpabilização da vítima no crime de estupro – “As Medusas Contemporaneas”
Authors: De Almeida Fabricio , Fidalgo Roberta
Published: February 2022

As mulheres, vitimadas dos crimes de estupro possuem a tendência de serem culpabilizadas por parte da sociedade devido o seu comportamento, pois, suas palavras passam por um juízo de valoração nesses crimes acabam, muitas vezes, sendo questionadas pelos operadores do Direito. Os números de vítimas mulheres, nos crimes de estupro são enormes segundo os dados da Organização das Nações Unidas, constatando-se uma preocupação mundial. O estupro não faz especificação da vítima e nem do agressor, e poderá esse, ser qualquer indivíduo, sem que tenha importância a idade, raça, nível cultural, classe social, dentre outros. Desta forma, o presente estudo apresenta as formas de depreciação das mulheres na forma mais lendária conhecida como: O Estupro da sacerdotisa de Atena, chamada Medusa, e tem como objetivo identificar os principais pontos controversos da cultura de culpabilização das mulheres, vítimas de estupro. Conclui-se que, no que tange aos crimes de estupro, existe um julgamento da sociedade, operadores do direito e as partes envolvidas, na contestação da palavra da vítima, no julgamento de comportamentos com previsão fora do espectro jurídico. A analogia da história da Medusa ao crime, revela uma verdade em que há mais a ser desvendado sobre seu mito. Alguns pontos não tão populares, mas que a transformam em uma das mulheres mais fortes da Mitologia Grega. Pontos que fazem relação com muito do que ainda é ser mulher, mesmo na contemporaneidade. O conto parece muito familiar: uma jovem é obrigada a fazer algo que não quer. Uma autoridade descobre. A vítima é punida, enquanto o outro/ agressor sai ileso, sem consequências. Esses fatos não podem se relacionar, sendo que, o comportamento da vítima precisa ter verificação dentro do contexto criminal. Além do mais, há uma falta de amparo da sociedade, não dando o devido apoio às vítimas do crime de estupro, o que incentiva, diversas vezes e não realizar a “denúncia” do fato para as autoridades competentes. Por fim, não é possível que haja ainda, a aceitação de uma sociedade contemporânea, na qual as mulheres sejam visualizadas de maneira tão misógina e discriminatória. Dessa forma, ao usar a Mitologia Grega até hoje em tantos momentos do nosso dia a dia, só faz sentido se for para visualizar Medusa cada vez mais pelo que ela realmente é: um símbolo da força feminina, mas que foi duplamente vitimizada: Primeiro em razão de seu estupro e segundo pela maldição a qual foi condenada por ser entendida como a culpada pelo ato.
A divisão sexual do trabalho na mineração no quadrilátero ferrífero de Minas Gerais: apontamentos e questões introdutórias que (des)inviabilizam (novas) sujeitas que são exploradas na mineração
Authors: Silva Kyara Mariana Corgosinho , Bomfim Rainer , Coelho Bianca Lemos
Published: February 2022

As transformações no trabalho da mulher são contínuas, mas a crescente ocupação feminina no mercado laboral não foi suficiente para acabar com a desigualdade de gênero. A divisão sexual do trabalho continuou a mostrar as desigualdades sistemáticas que permaneceram em situações diferentes, mediante “novas faces” da discriminação do trabalho feminino. Sob este aspecto, a desigual ocupação feminina na atividade de mineração é profunda e evidencia os abismos entre os gêneros no mercado de trabalho. Nesse sentido, na mineração, é possível observar as limitações que enfrentam as mulheres, vez que esses espaços foram historicamente ocupados pela figura masculina. Nos termos da divisão sexual do trabalho, a atividade de mineração exige força física e trabalhos pesados, realizados em ambientes inóspitos e insalubres, que via de regra são associados ao estereótipo masculino, visto que exigem força e persistência; já as mulheres, principalmente as brancas, são associadas aos trabalhos mais leves, fáceis, limpos e delicados. Minas Gerais é uma área de histórica exploração de minério desde a colonização, de modo que é possível acompanhar o desenvolvimento social e econômico promovido por esta atividade. Tendo como cenário esse segmento industrial, a presente pesquisa jurídico-sociológica buscou verificar em qual medida a divisão sexual do trabalho permanece na atividade de mineração em Minas Gerais, verificando a inserção, permanência e ascensão profissional das mulheres nesta área.