bluuebunny/crossref_metadata_2025 huggingface dataset:
Foreign Animation Films and the Rising of Anti-Multiculturalism among Parents
Authors: Angeningsih Leslie Retno , Astuti Nuraini Dwi
Published: September 2019

As the impact of globalization, foreign animation films such as Shin Chan from Japan, Krishna from India, Upin-Ipin from Malaysia, Batman and many others from the US are very popular in Indonesia. Those films supposed represent cultures of each nation, so that people can learn multiculturalism. However, those films create inversely. This study aims to know how foreign animation films affect on the rising of anti-multiculturalism among Indonesian parents. Survey is conducted on parents with kindergarten or elementary children in Yogyakarta. The results show that children prefer to watch foreign animation films compare to domestic one. They are more likely to imitate their favorite animation stars by behaving violently, speaking harshly, and disrespectfully to parents.  As a result parents tend to blame their children changing behavior on foreign cultures as bad and impolite compare to their own culture. Instead of encouraging better understanding on multiculturalism, foreign animation films has raised anti-multiculturalism among parents.Sebagai dampak globalisasi, film animasi asing seperti Shin Chan dari Jepang, Krishna dari India, Upin Ipin - dari Malaysia, Batman dan banyak lainnya dari Amerika Serikat sangat populer di Indonesia. Film-film seharusnya mewakili budaya masing-masing negara, sehingga orang dapat belajar multikulturalisme. Namun, film-film ini dapat pula berakibat sebaliknya. Penelitian ini bertujuan untuk mengetahui bagaimana film animasi dari luar bisa berpengaruh pada peningkatan anti-multikulturalisme pada orang tua di Indonesia. Survey dilakukan pada orang tua yang memiliki anak TK atau SD  di Yogyakarta. Hasil menunjukkan bahwa anak-anak lebih memilih untuk menonton film animasi asing dibandingkan dengan film dalam negeri. Mereka lebih cenderung untuk meniru bintang animasi favorit mereka dengan berperilaku keras, berbicara kasar, dan tidak hormat kepada orang tua. Akibatnya, orang tua cenderung menyalahkan anak-anak mereka perilaku yang berubah pada budaya asing sebagai buruk dan tidak sopan dibandingkan dengan budaya mereka sendiri. Alih-alih mendorong pemahaman yang lebih baik tentang multikulturalisme, film animasi asing telah meningkatkan anti-multikulturalisme di kalangan orang tua.
Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents
Authors: Wolraich Mark L. , Hagan Joseph F. , Allan Carla , Chan Eugenia , Davison Dale , Earls Marian , Evans Steven W. , Flinn Susan K. , Froehlich Tanya , Frost Jennifer , Holbrook Joseph R. , Lehmann Christoph Ulrich , Lessin Herschel Robert , Okechukwu Kymika , Pierce Karen L. , Winner Jonathan D. , Zurhellen William ,   SUBCOMMITTEE ON CHILDREN AND ADOLESCENTS WITH ATTENTION-DEFICIT/HYPERACTIVE DISORDER
Published: September 2019

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and can profoundly affect children’s academic achievement, well-being, and social interactions. The American Academy of Pediatrics first published clinical recommendations for evaluation and diagnosis of pediatric ADHD in 2000; recommendations for treatment followed in 2001. The guidelines were revised in 2011 and published with an accompanying process of care algorithm (PoCA) providing discrete and manageable steps by which clinicians could fulfill the clinical guideline’s recommendations. Since the release of the 2011 guideline, the Diagnostic and Statistical Manual of Mental Disorders has been revised to the fifth edition, and new ADHD-related research has been published. These publications do not support dramatic changes to the previous recommendations. Therefore, only incremental updates have been made in this guideline revision, including the addition of a key action statement related to diagnosis and treatment of comorbid conditions in children and adolescents with ADHD. The accompanying process of care algorithm has also been updated to assist in implementing the guideline recommendations. Throughout the process of revising the guideline and algorithm, numerous systemic barriers were identified that restrict and/or hamper pediatric clinicians’ ability to adopt their recommendations. Therefore, the subcommittee created a companion article (available in the Supplemental Information) on systemic barriers to the care of children and adolescents with ADHD, which identifies the major systemic-level barriers and presents recommendations to address those barriers; in this article, we support the recommendations of the clinical practice guideline and accompanying process of care algorithm.
Current electronic journals on occupational therapy: A descriptive study
Authors: Cezar da Cruz Daniel Marinho , Costa Jacqueline Denubila , Veiga Jane , Manzini Mariana Gurian , De Araujo Costa Folha Otavio Augusto
Published: September 2019

Introduction: The quantity and quality of papers published in journals are often considered as research trends indicators in several fields of study. In the case of occupational therapy (OT) there are few studies addressing this issue.Objective: To describe the characteristics of occupational therapy electronic journals, including year of creation, publication frequency, peer review process, language of publication, and content access policies. Materials and methods: A descriptive, quantitative study was carried out based on a search conducted in the following databases by using the term “occupational therapy”: Web of Science, Scopus, SciELO, CINAHL, OTDBASE, Ulrich’s International Periodical Directory, NCBI Databases, CINAHL-EBSCOhost, ProQuest, Medline, and Directory of Open Access Journals. Simple descriptive statistics was used to analyze data. Results: After the search was conducted, 39 journals were included for analysis, of these 85% had been created after 1990. All journals were indexed in different databases, but most of them were in Journal Citation Reports, CINAHL, Medline, Science Citation Index Expanded, OTDBase, and PsycINFO. Likewise, approximately 36% publish an issue every three months, and mainly in English. Conclusion: A more comprehensive understanding of the characteristics of these journals may help OT researchers choosing the best option to submit their works for publication, and contribute to achieving higher rates of production and dissemination of knowledge on OT by said journals.
Impacto de las condiciones sociodemográficas sobre el control prenatal en Latinoamérica
Authors: Ipia-Ordóñez Nasly Violedy , Ortega-Vallejo Darío Fernando , Acosta-Mora Piedad Andrea , López-Lasso William Andrés , Martínez-Rodríguez Jhon Edward , Corrales-Zúñiga Norma Constanza , Rosero-Montero Carlos Andrés , Cedeño-Burbano Anuar Alonso
Published: September 2019

Introducción. El control prenatal corresponde a una estrategia encaminada a prevenir las posibles complicaciones del embarazo, el parto y el puerperio. Diversos estudios aislados se han realizado para identificar factores que pueden afectar de forma negativa el control prenatal.Objetivo. Realizar una síntesis cualitativa de la literatura respecto al impacto de las condiciones sociodemográficas sobre el control prenatal en Latinoamérica.Materiales y métodos. Se realizó una búsqueda de la literatura a junio de 2018 en las bases de datos EBSCO, Embase, ScienceDirect, LILACS, SciELO, Cochrane Library, MEDLINE-PubMed y Google Scholar, con los términos “prenatal care” AND “Health services accessibility” AND “Pregnancy, Health services accessibility” AND “Pregnancy, prenatal care” AND “Health services accessibility” y sin límite de tiempo.Resultados. Se encontraron 13 artículos con información relevante para el desarrollo de la presente revisión.Conclusiones. La literatura disponible sugiere que condiciones sociodemográficas desfavorables podrían incidir de manera negativa sobre el control prenatal. El cuidado del hogar, la atención de otros hijos, la afiliación al sistema de seguridad social, la obligación laboral y el desempleo parecen ser los principales factores que afectan la calidad del mismo.
Estudio de concordancia entre los resultados de la puntuación de Gleason de biopsias de próstata y los de la prostatectomía radical en pacientes con cáncer de próstata localizado
Authors: Cerquera-Cleves Diana María , Donoso-Donoso Wilfredo , Buitrago-Gutiérrez Giancarlo
Published: September 2019

Introducción. Existen diferencias entre la concordancia de la puntuación de Gleason en biopsias prostática y la patología final.Objetivos. Determinar la concordancia de las puntuaciones de Gleason obtenidas por biopsia de próstata y por prostatectomía radical (PR) en un hospital de IV nivel en Bogotá D.C., Colombia.Materiales y métodos. Estudio retrospectivo de pruebas diagnósticas realizado en un hospital de alta complejidad de Bogotá D.C. Fueron resisados los resultados de las PR y las biopsias prostáticas, clasificando los pacientes según D’Amico y la división por grupos realizada por patólogos. La concordancia diagnóstica se determinó mediante la estimación del coeficiente de Kappa ponderado.Resultados. Se incluyeron 180 pacientes con promedio de edad de 61 años. La exactitud diagnóstica de la puntuación de Gleason dada por biopsia fue de 52%, con supraestadificación del 34% y subestadificación del 14%. El índice Kappa ponderado entre la puntuación de Gleason de la biopsia prostática y la PR fue de 0.37 (p=0.000), y por grupos de 0.4 (p=0.000), con concordancia aceptable para la muestra.Conclusiones. La concordancia de la biopsia de próstata con la PR es baja con tendencia a la supraestadificación, lo que podría tener un impacto negativo en el manejo de los pacientes con cáncer de próstata localizado.
Physiological, molecular and genetic aspects of alpha-synuclein and its correlation with high alcohol consumption
Authors: Martínez-Rodríguez Tania Yadira , Rey-Buitrago Mauricio
Published: September 2019

Introduction: Significant changes in the expression of α-synuclein (SNCA) can be seen in subjects with high alcohol consumption, altering neuroprotection and causing changes in the reward system.Objective: To present state-of-the-art studies on the physiological, molecular and genetic aspects of SNCA related to high alcohol consumption.Materials and methods: A search of records published from 2007 to 2017 was carried out in PUBMED, ScienceDirect and Cochrane with the terms alpha-synuclein, alcoholism, genetic polymorphism, gene expression, DNA methylation and molecular biology.Results: The search yielded 1 331 references, of which 51 full-texts were selected. The results describe the current evidence of the physiological and pathological aspects of α-synuclein (SNCA) and the genetic and epigenetic changes related to its expression in people with high alcohol consumption.Conclusions: The evidence suggests that a differential expression of α-synuclein (SNCA) is found in subjects with high alcohol consumption, as a result of modifications in the genetic and epigenetic mechanisms, leading to physipathological neuroadaptations. SNCA is a promising marker in the field of alcoholism research; therefore, more studies are required in this regard, taking into account the genetic heterogeneity of each population.
Late recurrence of adrenocortical carcinoma and metastatic disease. Case report
Authors: Pérez-Ardila Maria Alejandra , Naranjo-Millán Julián , Giral Helman , Mugnier Jacqueline , Altamar Henry
Published: September 2019

Introduction: Adrenocortical carcinoma (ACC) is a malignancy with an annual incidence of 0.72 cases per million people. It is a rare tumor that is associated with high mortality in late stages, as well as with a 5-year survival of 13% in stage IV patients, and 61% in stage II lesions. Nevertheless, tumor recurrence occurs in up to 54% at 23 months with predominance of locoregional involvement, being striking the late presentation of tumor recurrence with extensive involvement.Case presentation: This is the case of a 52-year-old male patient with a history of resection of an ACC of 6cm five years earlier, who was admitted for decompensated heart failure. A chest x-ray was taken suggesting metastasis. After conducting biochemical studies and CT scan of the abdomen, ACC with metastases to liver and lung was diagnosed. The patient decided not to receive palliative chemotherapy.Conclusion: This unfortunate outcome is related to the lack of follow-up after the initial procedure. Clinical, hormonal, and imaging evaluation is recommended every 3 months for 2 years, and then at least every 6 months.
Sociodemographic, criminal and forensic characteristics of a sample of female children and adolescents murdered in Brazil. 2010-2016
Authors: Machado-Rios Angelita , Martini Murilo , Cardoso-Crespo Kleber , Fraga-Morales Anderson , Vieira-Da Silva Magalhães Pedro , Borba-Telles Lisieux Elaine
Published: September 2019

Introduction: In Brazil, violence, regardless of the type, is the leading cause of death in adolescents and young adults.Objective: To describe the characteristics of the homicides in which female children and adolescents were the victims based on the autopsy reports recorded in the morgue of the city of Porto Alegre, Brazil.Materials and methods: Cross-sectional study in which 70 autopsy reports of girls and female adolescents who were killed between January 2010 and December 2016 were analyzed. The cases were evaluated according to the homicide motive or the homicide perpetrator, and five categories were established: drug trafficking related death, femicide, homicide perpetrated by a family member, death preceded by sexual violence, and death related to other transgressions.Results: There was a significant increase in the number of girls and female adolescents who were murdered between 2010 (n=7) and 2016 (n=19). Most of the homicides (64.2%) were related to drug, while femicide occurred in 15.7% of the cases. Homicides perpetrated by a family member, or preceded by sexual violence or related with other transgressions were less frequent as they occurred in 10%, 5.7% and 4.2% of the cases, respectively.Conclusion: Greater attention must be paid to the increase in the number of drug trafficking related homicides among female adolescents when creating and implementing relevant public policies.
DXA–BMD OR VITAMIN D3– THE BETTER PREDICTOR OF OSTEOPOROSIS– A PILOT STUDY IN URBAN INDIAN POPULATION
Authors: DR. SUHASISH RAY
Published: September 2019

Objective: We aimed to examine the relationship between the levels of vitaminD, T and Z score using Dexa BMD in patients with chronic low back pain(CLBP) to investigate which of these factors is an essential investigation for asubject attendind spine clinic with chronic LBP.Methods: 299 subjects (female/male: 154:145) with CLBP, aged between 20 and60 years (mean age:45.05 ± 8.14), participated in the study. Patients wereclassified into three groups based on their serum vitamin D levels and T scoreand Z score : SPSS version 20 was the tool of statistical assessment.Results: T and Z score estimation through Dexa BMD was found to have abetter predictor for assessment and intervention than Vitamin D3.Conclusion: DEXA BMD is an inevitable tool to assess osteoporosis apart fromany value of Vitamin D3 irrrespective of age, sex and body weightLevel ofEvidence: Level IV, Retrospective record based study.Key words: DXA-BMD; Vitamin d3; T score; Z score; CLBP;retrospective record based study.
Modified multi-valued method as an effective way of identifying investment areas, as illustrated with the example of Dobczyce town
Authors: Litwin Urszula , Misiak Karolina
Published: September 2019

The multi-valued method proposed by Walerian Wierzchowski [1996], subsequently modified
by U. Litwin and K. Misiak, is a combination of cartographic research methods and mathemati-
cal analyses. The proposed technique presented in action can be viewed as a series of feasibility
studies, which are the necessary foundation for programming the optimal structure of land use
in urban areas.
As exemplified in the collected information, various cartographic studies and existing data
about the town of Dobczyce, four possible designated functions have been presented, of which
priority was given to the industrial function. The obtained results confirmed the effectiveness of
the developed method, its usefulness in the planning practice, while highlighting the synergistic
effects of the set objectives
Problems of tourism development of sea-coast zones, as illustrated with the example of Ustka town
Authors: Uruszczak Michał
Published: September 2019

The town of Ustka is a health resort located in Central Pomerania, situated within the coastal
zone, and serving tourism, agricultural and forest functions in this region of Poland. Spatial
development resulting from the immediate vicinity of the sea and related environmental condi-
tions is visible within the space, which is the subject of the present analysis. The fragment of
the coastal zone, which functions as the main area of recreation and leisure within the town of
Ustka, has been examined. The article presents the analysis of the particular features typifying
the local development of the eastern part of the Baltic coast belt in the town of Ustka, as well
as its general evaluation, and indication of the possibilities for tourism adaptation of one of the
spaces within this area of the discussed town.
In addition, one of the goals of the present work is to draw attention to the landscape-related
legal problem of unfinished construction projects, particularly troublesome in places that suffer
from the deficit of spaces dedicated to leisure activity. A classic example is the ruin of a hotel in
Ustka town, discussed in the present article
Infrastructure investment projects in terms of conformity with domains of sustainable development — a comparative analysis of municipalities in the vicinity of Olsztyn city, in Warmia and Mazury region, Poland
Authors: Kocur-Bera Katarzyna
Published: September 2019

The concept of sustainable development has a number of definitions. In a general sense, it as-
sumes interdependence and equivalence of three domains of reality: environment, society and
economy. Harmonisation of the relationship between the society, the economy and the natu-
ral environment requires the development of new, more efficient and environmentally-friendly
technologies, limiting the exploitation of natural resources, energy consumption, the elimination
of environment-polluting forms of production, as well as a widespread change of the way of life
and revision of the acceptable hierarchy of values. According to the valid principles, the invest-
ment trends in municipalities should be in line with the domains of sustainable development,
thereby providing balance in all the three areas of investment: environmental, economic and so-
cial. The aim of the study is to conduct a comparative analysis of the investment projects carried
out in the period of 2007–2013 in selected municipalities of the Warmia and Mazury Region for
their compliance with the principles of sustainable development of rural areas. Investment pro-
jects co-financed from EU funds were examined. This has allowed us to highlight the spheres of
investment, which drew particular attention within the period of time under study. The shifted
focus of investment efforts also testifies to backwardness in the supported sphere.
Sunflower Stalk Based Activated Carbon for Supercapacitors
Authors: YÜRÜM Alp
Published: September 2019

In
this study, a combination of physical and chemical activation was used to
produce activated carbon from sunflower stalks. The NaOH activated carbon
possess a high specific surface area of 2658 m2/g. The micropore
fraction and surface area obtained is much higher than a commercial activated
carbon. The electrodes from the activated carbons were electrochemically
analyzed in a two-electrode supercapacitor cell with 1 M H2SO4
electrolyte. The results show that the high surface area of sunflower activated
carbon resulted in significantly high specific capacitance of 207 F/g at 0.05
A/g current density. Moreover, a high energy density of 18.4 Wh/kg was obtained
at the power density of 80 W/kg. The results also showed the importance of pore
structure on the supercapacitor performance.
Veterinarians’ Perception, Knowledge and Practices of Hand Hygiene in Enugu State Southeast, Nigeria
Authors: ANYANWU Madubuike U. , NWOBI Obichukwu C. , AJOKE Oluwatosin K.
Published: September 2019

A cross-sectional survey utilizing questionnaire assessed veterinarians’ awareness, attitudes and practices of hand hygiene (HH) in Enugu State Southeastern Nigeria. Data obtained were analyzed using chi-square on SPSS (version 15.0) at a significance level of P < 0.05 to determine possible associations between variables and perceptions/knowledge about HH. Out of 294 respondents, 26.9% were familiar with the WHO’s “5 moments of HH” model but majority knew the importance of the model. There was high compliance with HH after touching an animal (100%) and animal’s surrounding (96%), and contact with body fluid (100%) but HH before touching an animal (52.5%) and performing clean procedures (58.5%) were practiced sub-optimally. Majority of the respondents often forgets to perform HH (61.9%) and prioritizes clinical tasks to HH when busy (65%). The attitudes/practices towards HH were generally negative. Minority knew that unclean veterinary personnel’s hands are the main route of infection in the veterinary clinic (38.1%) and alcohol-based hand rubs are more effective on pathogens than other cleansing agents (23.1%). Majority of the respondents does not know when different HH techniques ought to be performed. The overall knowledge of HH by the respondents was moderate (55.4%). No significant association (P > 0.05) was found between level of knowledge and gender, age, qualification, duration of practice and location. Poor knowledge of HH guidelines, unavailability and inaccessibility of HH facilities, and unavailability of reminders were the major barriers to compliance with appropriate HH practices. In conclusion, veterinarians’ awareness and perception about HH in the study area is moderate while the practices are sub-optimal, thus the education of Nigerian veterinarians about HH and the teaching of the principles and practices of appropriate HH during veterinary schools are recommended.
Pharmacological Uses and Health Benefits of Ginger (Zingiber officinale) in Traditional Asian and Ancient Chinese Medicine, and Modern Practice
Authors: SHAHRAJABIAN Mohamad Hesam , SUN Wenli , CHENG Qi
Published: September 2019

Ginger (Zingiber officinale) has been used as a spice and a medicine for over 200 years in traditional Chinese medicine. Ginger is an important plant with several medicinal and nutritional values used in Asian and Chinese tradition medicine. Ginger and its general compounds such as Fe, Mg, Ca, vitamin C, flavonoids, phenolic compounds (gingerdiol, gingerol, gingerdione and shogaols), sesquiterpenes, paradols has long been used as an herbal medicine to treat various symptoms including vomiting, pain, cold symptoms and it has been shown to have anti-inflammatory, anti-apoptotic, anti-tumor activities, anti-pyretic, anti-platelet, anti-tumourigenic, anti-hyperglycaemic, antioxidant anti-diabetic, anti-clotting and analgesic properties, cardiotonic, cytotoxic. It has been widely used for arthritis, cramps, sprains, sore throats, rheumatism, muscular aches, pains, vomiting, constipation, indigestion, hypertension, dementia, fever and infectious diseases. Ginger leaves have also been used for food flavouring and Asian traditional medicine especially in China. Ginger oil also used as food flavouring agent in soft drink, as spices in bakery products, in confectionary items, pickles, sauces and as a preservatives. Ginger is available in three forms, namely fresh root ginger, preserved ginger and dried ginger. The pharmacological activities of ginger were mainly attributed to its active phytocompounds 6-gingerol, 6-shogaol, zingerone beside other phenolics and flavonoids. Gingerol and shogaol in particular, is known to have anti-oxidant and anti-inflammatory properties. In both traditional Chinese medicine, and modern China, Ginger is used in about half of all herbal prescriptions. Traditional medicinal plants are often cheaper, locally available and easily consumable raw and as simple medicinal preparations. The obtained findings suggest potential of ginger extract as an additive in the food and pharmaceutical industries.
Generic Salmonella in Asymptomatic Adult Volunteers: Occurrence, Antibiogram, Extended-Spectrum β-Lactamase Production and Carbapenem Resistance
Authors: OKPALANWA Chiamaka , ANYANWU Madubuike U. , MOMOH Mumuni A. , NNAMANI Petra O. , ATTAMA Anthony A.
Published: September 2019

This study was conducted to isolate generic Salmonella from stool of apparently-healthy/asymptomatic adult volunteers in Ankpa North-central Nigeria, and to determine antibacterial susceptibility, extended-spectrum β-lactamase production and carbapenem resistance. About a gram of stool was collected from 295 randomly-selected apparently-healthy/asymptomatic adult volunteers in Ankpa Kogi State, North-central Nigeria. Isolation of Salmonella was done by pre-enrichment with buffered peptone water, enrichment with Rapapport-Vassiliadis and sub-culturing on Salmonella-Shigella and MacConkey agar. Identification of the isolates to genus level was done using standard biochemical tests. Resistance of the isolates was determined by disc diffusion method. Production of ESBL was assessed by combination disc method while carbapenem resistance was determined using meropenem disc screening method. Nine (3.1%) out of 295 samples, gave positive growth of Salmonella. Of these 9 isolates, all were carbapenem (meropenem)-resistant and 1 (11.1%) was ESBL-producer. Among the isolates, all were resistant to ciprofloxacin, ofloxacin, norfloxacin, ampicillin, cefotaxime, ceftazidime, gentamicin and streptomycin, 5 (55.6%) to sulphamethoxazole-trimethoprim, 7 (77.8%) to amoxicillin-clavulanic acid and aztreonam, 6 (66.7%) to nitrofurantoin and 8 (88.9%) to tetracycline. All the isolates were resistant to ≥ 5 classes of antibacterial agents. Mean multiple antibacterial indexes of the isolates were 0.68 (range 0.79 - 1.00). Apparently-healthy/asymptomatic adults in Ankpa North-central Nigeria, are potential reservoirs and disseminators of multi- and extensive-drug resistant salmonellae.
Effects of Weed Density and Distance on the Growth and Yield of Two Okra (Abelmoscus esculentus) Varieties
Authors: OPADOKUN Wasiu Olanrewaju , OLORUNMAIYE Kehinde Stephen
Published: September 2019

A field experiment was conducted at the botanical garden of the University of Ilorin to determine the effects of weed density and distance on the growth and yield of two varieties of okra (NHAe-40 days and Kirikoi). The experiment was a complete randomized block design with eleven treatments and three replicates. The treatment details include T0 = No weed, T1 = One weed per plant T2= Two weeds per plant, T3 = Three weeds per plant, T4 = Four weeds per plant, T5 = Five weeds per plant, T6 = Six weeds per plant, T7 = Seven weeds per plant, T8 = Eight weeds per plant, T9 = Nine weeds per plant and T10 = Ten weeds per plant.  Data were collected on plant height, number of leaves, stem girth, shoot Fresh and dry weight as well as yield parameters was carried out at the end of the experiment. The result depicts a significant decrease in the vegetative growth and yield parameters with increasing weed density in both varieties. Irrespective of the weed distance, all yield parameters decreased significantly with increasing number of co-habiting weeds except for plant co-habited with one weed at 20 cm and 30 cm weed distance which was significantly the same with the control in both varieties. The result is an indication that absence of weed or early control of weed should be done at the early weeks of growth before the onset of flowering if maximum production is expected.
Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat
Authors: DANDAPAT Sukumar , KUMAR Manoj , RANJAN Rakesh , SINHA Manoranjan P.
Published: September 2019

Ganoderm applanatum is a polypore macrofungi and traditionally used as medicine rather than fodder. Silver nanoparticles mediated by G. applanatum extract were synthesized, characterized and toxicity impacts were investigated for their pharmacological and medicinal uses. The synthesized silver nanoparticles were of average 58.78 nm in diameter with -13.8 mV zetpotential, analysed by dynamic light scattering method. Fourier transform infrared spectroscopy analysis of synthesized nanoparticles confirmed the capping and stabilizing with mycochemicals, that showed transmittance at   3606 cm-1 corresponds to O-H stretch for phenol, 2430 cm-1 corresponds to N-H stretch for primary and secondary amines. 2000 mg kg-1, 200 mg kg-1 and 400 mg kg-1 doses of silver nanoparticles showed non-significant (p<0.05) increase in body weight and organ weight. Non-significant increase in RBC indices were observed and significant (p<0.05) increase in WBC count (7.28±0.41 × 103 µL-1 and 8.41±0.35 × 103 µL-1) at 200 mg kg-1 and 400 mg kg-1 doses of silver nanoparticles  were observed. Thus, G. applanatum extract mediated silver nanoparticles can be used pharmacologically and medicinally due to their nontoxic effect.
Prevalence of Group A Rotavirus, Some Risk Factors and Clinical Signs of the Infection in Children Under Five Years in Yobe State, Nigeria
Authors: GARBA John , FALEKE Olufemi O. , MAGAJI Abdullahi A. , ALKALI Bello R. , NWANKWO Innocent O. , DZIKWI Asabe A.
Published: September 2019

Diarrhoea in children is caused by variety of disease agent including Rotavirus. With the increase in child mortality rate in the state which has been associated with lack of adequate hygiene’s especially for those displaced from their homes, Rotavirus infection may have often been misdiagnosed since the zoonotic potentials, prevalence in children, associated risk factors and clinical signs have not been fully elucidated in Nigeria. These were determined in children who were presented for treatments for gastroenteritis in Government Hospital in Yobe State, Nigeria between the period of April 2014-May 2016 using structured questionnaire and ELISA kit. Rotavirus was detected in 18.1% (30/166) of the patients, 18.4% (16/87) and 17.7% (14/79) were in males and females respectively, while 17.7% (17/96), 15.4% (8/52), 27.8% (5/18) were for ages (<1-24, 25-48 and 49-60) months old respectively. Rotavirus infection was significantly associated (P ˂ 0.05) with age, day-care, signs of vomiting, mother’s educational status, type of stool and duration,  unlike in type of food, drinking water, presence of fever, animal contact and father’s occupation (P >  0.05). Rotavirus is in circulation in the state and the clinical signs and some of the risk factors were significantly associated with the infection, thus will aid in early diagnosis, prevention and control of the virus spread in Nigeria.
Introduction Pages
Authors: SESTRAS Radu E.
Published: September 2019

Notulae Scientia Biologicae (http://www.notulaebiologicae.ro), Issue 3, Volume 11, 2019: The papers published in this issue (https://www.notulaebiologicae.ro/index.php/nsb/issue/view/265) represent interesting novelties in different topics of life science. Among the exciting researches, we invite readers to find news about: pharmacological uses and health benefits of ginger (Zingiber officinale) in traditional Asian and ancient Chinese medicine, and modern practice; middle east respiratory syndrome: its occurrence, aetiology, epidemiology, associated clinicopathological findings, diagnosis, prevention and control in humans and animals; ethanolic extract of Chrysophyllum albidum stem bark prevents alloxan-induced diabetes; prevalence of group a rotavirus, some risk factors and clinical signs of the infection in children under five years in Yobe State, Nigeria; prevalence of increased serum urea and creatinine levels in dogs; impact of heat stress on blood and serum biochemistry parameters in rats; acute and sub-acute toxicity of Ganoderma applanatum (Pres.) Pat. extract mediated silver nanoparticles on rat; in-vitro control of oral thrush causal organisms using medicinal plants extracts; generic salmonella in asymptomatic adult volunteers: occurrence, antibiogram, extended-spectrum β-lactamase production and carbapenem resistance; impact of hydrogen peroxide on the secondary metabolites, enzyme activities and photosynthetic pigment accumulation of Vigna unguiculata L. (Walp); diversity, distribution and conservation status of the genus Tectaria Cav. from Deccan Peninsula and western Ghats of India.
Associations of Polypharmacy and Inappropriate Medications with Adverse Outcomes in Older Adults with Cancer: A Systematic Review and Meta-Analysis
Authors: Mohamed Mostafa R. , Ramsdale Erika , Loh Kah Poh , Arastu Asad , Xu Huiwen , Obrecht Spencer , Castillo Daniel , Sharma Manvi , Holmes Holly M. , Nightingale Ginah , Juba Katherine M. , Mohile Supriya G.
Published: September 2019

Background

Polypharmacy (PP) and potentially inappropriate medications (PIM) are highly prevalent in older adults with cancer. This study systematically reviews the associations of PP and/or PIM with outcomes and, through a meta-analysis, obtains estimates of postoperative outcomes associated with PP in this population.

Materials and Methods

We searched PubMed, Embase, Web of Science, and Cochrane Register of Clinical Trials using standardized terms for concepts of PP, PIM, and cancer. Eligible studies included cohort studies, cross-sectional studies, meta-analyses, and clinical trials which examined outcomes associated with PP and/or PIM and included older adults with cancer. A random effects model included studies in which definitions of PP were consistent to examine the association of PP with postoperative complications.

Results

Forty-seven articles met the inclusion criteria. PP was defined as five or more medications in 57% of the studies. Commonly examined outcomes included chemotherapy toxicities, postoperative complications, functional decline, hospitalization, and overall survival. PP was associated with chemotherapy toxicities (4/9 studies), falls (3/3 studies), functional decline (3/3 studies), and overall survival (2/11 studies). A meta-analysis of four studies indicated an association between PP (≥5 medications) and postoperative complications (overall odds ratio, 1.3; 95% confidence interval [1.3–2.8]). PIM was associated with adverse outcomes in 3 of 11 studies.

Conclusion

PP is associated with postoperative complications, chemotherapy toxicities, and physical and functional decline. Only three studies showed an association between PIM and outcomes. However, because of inconsistent definitions, heterogeneous populations, and variable study designs, these associations should be further investigated in prospective studies.
Regorafenib in Combination with First-Line Chemotherapy for Metastatic Esophagogastric Cancer
Authors: Moy Ryan H. , Dos Santos Fernandes Gustavo , Jonsson Philip , Chou Joanne F. , Basunia Azfar , Ku Geoffrey Y. , Chalasani Sree B. , Boyar Michelle S. , Goldberg Zoe , Desai Avni M. , Gabler Amelia , Berger Michael F. , Tang Laura H. , Hechtman Jaclyn F. , Kelsen David P. , Schattner Mark , Ilson David H. , Solit David B. , Taylor Barry S. , Schultz Nikolaus , Capanu Marinela , Janjigian Yelena Y.
Published: September 2019

Background

Angiogenesis is critical to gastroesophageal adenocarcinoma growth and metastasis. Regorafenib is a multikinase inhibitor targeting angiogenic and stromal receptor tyrosine kinases. We evaluated whether regorafenib augments the antitumor effect of first-line chemotherapy in metastatic esophagogastric cancer.

Materials and Methods

Patients with previously untreated metastatic gastroesophageal adenocarcinoma received 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) every 14 days and regorafenib 160 mg daily on days 4 to 10 of each 14-day cycle. The primary endpoint was 6-month progression-free survival (PFS). To identify predictive biomarkers of outcome, we examined correlations between genomic characteristics of sequenced pretreatment tumors and PFS.

Results

Between August 2013 and November 2014, 36 patients with metastatic esophagogastric cancer were accrued to this single-center phase II study (NCT01913639). The most common grade 3–4 treatment-related adverse events were neutropenia (36%), leucopenia (11%) and hypertension (8%). The 6-month PFS was 53% (95% confidence interval [CI], 38%–71%), the objective response rate was 54% (95% CI, 37%–70%), and the disease control rate was 77% (95% CI, 67%–94%). Next-generation sequencing did not identify any genomic alterations significantly correlated with response, and there was no association between homologous recombination deficiency and PFS with platinum-based chemotherapy.

Conclusion

Regorafenib (one week on–one week off schedule) is well tolerated in combination with first-line FOLFOX but does not improve 6-month PFS relative to historical control.
A Phase II Study of Perioperative Capecitabine plus Oxaliplatin Therapy for Clinical SS/SE N1-3 M0 Gastric Cancer (OGSG 1601)
Authors: Terazawa Tetsuji , Matsuyama Jin , Goto Masahiro , Kawabata Ryohei , Endo Shunji , Imano Motohiro , Fujita Shoichiro , Akamaru Yusuke , Taniguchi Hirokazu , Tatsumi Mitsutoshi , Lee Sang-Woong , Kurisu Yoshitaka , Kawakami Hisato , Kurokawa Yukinori , Shimokawa Toshio , Sakai Daisuke , Kato Takeshi , Fujitani Kazumasa , Satoh Taroh
Published: September 2019

Lessons Learned

Perioperative capecitabine and oxaliplatin (CapeOx) therapy showed favorable efficacy with sufficient pathological response. Small sample size limited the statistical power of this result. Perioperative CapeOx therapy showed good feasibility. Further studies with larger sample size are required to validate this novel approach.

Background

D2 gastrectomy followed by adjuvant S-1 is the standard therapy for patients (pts) with stage III gastric cancer (GC) in Japan; however, the outcome is not satisfactory. We examined the efficacy of perioperative capecitabine and oxaliplatin (CapeOx) in pts with GC.

Methods

The eligibility criteria included confirmed clinical T3(SS)/T4a(SE) N1-3 M0 GC according to the Japanese Classification (JCGC; 3rd English Edition). Three cycles of neoadjuvant CapeOx (NAC; capecitabine, 2,000 mg/m2 for 14 days; oxaliplatin, 130 mg/m2 on day 1, every 3 weeks) were administered, followed by five cycles of adjuvant CapeOx (AC) after D2 gastrectomy. The primary endpoint was the pathological response rate (pRR) according to the JCGC (≥grade 1b).

Results

Thirty-seven pts were enrolled on CapeOx. An R0 resection rate of 78.4% (n = 29) and a pRR of 54.1% (n = 20, p = .058; 90% confidence interval [CI], 39.4–68.2) were demonstrated. Among 27 pts who initiated AC, 21 (63.6%) completed the treatment. Grade 3–4 toxicities during NAC included neutropenia (8%), thrombocytopenia (8%), and anorexia (8%) and during AC included neutropenia (37%), diarrhea (4%), and anorexia (4%).

Conclusion

Perioperative CapeOx showed good feasibility and favorable efficacy with sufficient pathological response, although statistical significance at .058 did not reach the commonly accepted cutoff of .05. The data obtained using this novel approach warrant further investigations.
Lateral dynamic bridge deck–pier interaction for ultra-high-speed Hyperloop train loading
Authors: Ahmadi Ehsan , Alexander Nicholas A. , Kashani Mohammad M.
Published: September 2019

The next generation of ultra-high-speed (UHS) trains, known as Hyperloop and TransPod, are aerospace type vehicles designed to carry passengers. The UHS employs a vehicle capsule within a protected vacuum tube deck, supported by reinforced concrete piers (i.e. multi-span viaduct). The tube environment allows multiple UHS vehicles to run in parallel simultaneously (i.e. twin tube deck) where asymmetric train loading will result in a large dynamic unbalanced moment on the piers. Therefore, exploring the lateral dynamic interaction of bridge deck (twin tube) and piers under such an unbalanced moment is an extremely important factor for the analysis of viaducts under dynamic UHS train loading. Hence, this paper analytically addresses the dynamic bridge deck–pier interaction under UHS train loading for lateral vibration.
Hydro-mechanical analysis of a surficial landslide triggered by artificial rainfall: the Ruedlingen field experiment
Authors: Sitarenios Panagiotis , Casini Francesca , Askarinejad Amin , Springman Sarah
Published: September 2019

This paper interprets the hydromechanical behaviour of a steep, forested, instrumented slope during an artificial rainfall event, which triggered a shallow slope failure 15 h after rainfall initiation. The soil's mechanical response has been simulated by coupled hydro-mechanical finite-element analyses, using a critical state constitutive model that has been extended to unsaturated conditions. Failure occurs within a colluvium shallow soil cover, characterised as a silty sand of low plasticity. The hydraulic and mechanical parameters are calibrated, based on an extended set of experimental results, ranging from water retention curve measurements to triaxial stress path tests under both saturated and unsaturated conditions. Rainfall is simulated as a water flux at the soil surface and suitable boundary conditions account for the hydromechanical interaction between the soil cover and the underlying bedrock. The results are compared with field data of the mechanistic and the hydraulic responses up to failure and are found to provide a very satisfactory prediction. The study identifies water exfiltration from bedrock fissures as the main triggering agent, resulting in increased pore pressures along the soil–bedrock interface, reduced available shear strength and cause extensive plastic straining, leading to the formation and propagation of a failure surface.
The severity of plastic shrinkage cracking in concrete: a new model
Authors: Sayahi Faez , Emborg Mats , Hedlund Hans , Cwirzen Andrzej , Stelmarczyk Marcin
Published: September 2019

Plastic shrinkage cracking in concrete is mainly a physical process, in which chemical reactions between cement and water do not play a decisive role. It is commonly believed that rapid and excessive moisture loss due to evaporation is the primary cause of the phenomenon. This paper presents a new model to estimate the severity of plastic shrinkage cracking, based on the initial setting time and the amount of water evaporating from within the concrete bulk. A number of experiments were performed under controlled ambient conditions, during which the water/cement ratio, cement type and dosage of superplasticiser were altered. The results, alongside those reported by other researchers, were utilised to check the validity of the proposed model. According to the outcomes, the model could predict the cracking severity of the tested concretes with good precision.
Additional faunistic records of the family Staphylinidae (Coleoptera) from Balikesir province of Turkey
Authors: VARLI Sakin Vural , TÜVEN Aylin , SÜRGÜT Hakan , ÖRGEL Semih
Published: September 2019

With this study was
aimed to determination of Staphylinidae species by using the window and pitfall traps from 11
different localities forests with old hollow oaks and beeches in Balıkesir
province in western Turkey, during years of 2012 and 2013. As a result of this
study, in totally 29 species, one species of Tachyporinae, two species of Omaliinae, three
species of Oxytelinae, four species of Aleocharinae, seven species of
Paederinae and twelve of Staphylininae belonging to Staphylinidae, were
recorded from Balıkesir province of Turkey. Amongst them, Omalium cinnamomeum
Kraatz, 1857, Anotylus tetracarinatus
(Block, 1799), Bledius furcatus
(Olivier, 1811) and Domene stilicina
(Erichson, 1840) are reported from Marmara
Region of Turkey for the first time. In addition, 18 species were new to the Balıkesir
province.
Tractable Rare Disaster Probability and Options-Pricing
Authors: Barro Robert J. , Liao Gordon Y.
Published: September 2019

We derive an option-pricing formula from recursive preference and estimate rare disaster probability. The new options-pricing formula applies to far-out-of-the money put options on the stock market when disaster risk dominates, the size distribution of disasters follows a power law, and the economy has a representative agent with Epstein-Zin utility. The formula conforms with options data on the S&amp;P 500 index from 1983-2018 and for analogous indices for other countries. The disaster probability, inferred from monthly fixed effects, is highly correlated across countries, peaks during the 2008-2009 financial crisis, and forecasts equity index returns and growth vulnerabilities in the economy.
Happiness Management en la época de la Industria 4.0
Authors: Ravina Ripoll Rafael , Marchena Domínguez José , Montañés Del Rio Miguel Ángel
Published: September 2019

La era de la industria 4.0 se está caracterizando, por un lado, en la existencia de sistemas de gobernanza que gradualmente está erosionando el Estado de Bienestar. Y por otro, en la implementación de modelos de gestión empresariales basados en la precariedad laboral y la reducción masiva de puestos de trabajos derivados de la automatización de los procesos productivos y el uso extensivo de los robots. Todos estos factores influyen negativamente en la felicidad de los seres humanos, especialmente en ecosistemas que viven alejados de los principios rectores del bienestar y la justicia. Ante esta realidad, el objeto de este artículo es poner sobre el tapete académico que el Happiness Management constituye una importante pieza axial en la generación de empresas que cultiven el círculo virtuoso de la felicidad y la creación de una atmósfera positiva en el interior de las organizaciones que estimulen la innovación y la creatividad. De esta forma se puede construir -en plena perturbación tecnológica-, un capitalismo inclusivo que amortigüe las desigualdades sociales a partir de empresas que lleven a cabo modelos de gestión sustentados en el Happiness Management. Teniendo presente que el capital humano del sector industrial no está aprovechando los frutos que originan los robots en su trabajo diario. Esto también precisa efectuar una breve reflexión sobre modelos de sostenibilidad medioambiental y convivencia social que garanticen un futuro generacional estable y feliz.
El bienestar subjetivo a partir de la creatividad y la percepción de felicidad
Authors: Ahumada-Tello Eduardo
Published: September 2019

El presente trabajo analiza la relación que existe entre los constructos de Felicidad y Creatividad con el Estado de Bienestar. La importancia de estos elementos se revisa para confirmar la relación positiva que se asume para de esta manera proponer estrategias de desarrollo organizacional. Los objetivos son encontrar la correlación entre las variables en el entorno local. Para ello se lleva a cabo la aplicación de un cuestionario que incluye ítems para cada una de las variables que conforman el estudio y se obtuvieron 249 respuestas que son parte de la muestra de una población correspondiente a estudiantes universitarios y a egresados de carreras administrativas en la ciudad de Tijuana, B.C., México. Los resultados confirman que las variables Felicidad y Estado del Bienestar presentan una alta correlación con resultado en Pearson (r = 0.672 y p < 0.001) y Spearman (rho = 0.687, p < 0.001) de la misma manera, las variables Creatividad y Estado de resultados tienen los siguientes resultados en Pearson (r = 0.406 y p < 0.001) y en Spearman (rho = 0.375, p < 0.001). Se concluye la importancia de elaborar estrategias de desarrollo de creatividad y percepción de felicidad para incrementar el estado de bienestar en los individuos y la organizaciones a partir de redes de colaboración y herramientas organizacionales para tal efecto.