bluuebunny/crossref_metadata_2025 huggingface dataset:
Transiting from Units to Inclusive Education: Implication on Intellectual Disability Pupils’ Skills Development; Case Study at Dodoma City
Authors: - Yusta
Published: March 2024

The study explored of the transiting the pupils with intellectual disability from units to inclusive education in Dodoma city council, Tanzania. A field study research design was used to achieve the study objective. The sample of this study was purposively selected from thirty-six (36) primary schools. Created eight (8) participants which involved six (6) participants were special teachers in two units’ class means three 3 in Chinangali unit and others Mlezi unit, and two (2) participant were school heads in Chinangali and Mlezi an inclusive school. The study adopted a descriptive survey design where by qualitative approach used. Interview and observation were used to collect data. The findings revealed that high enrollment rate of children with intellectual disability in units, the teachers-pupil’s ratio insufficient, inadequate teaching and learning materials, and learning environment is not conducive. Therefore, it is recommended that special teachers, curriculum develop and addition building classes.
Cardiovascular Disease Detection using Deep Learning
Authors: - AADIT TRIVEDI , - AARYA SHAH , - Dr. M. L. Sworna Kokila
Published: March 2024

Cardiovascular diseases have surged as the leading global cause of death, necessitating a focus on early detection and continuous monitoring. This study employs deep learning, specifically the MobileNet Architecture, on a public ECG dataset to predict four cardiac abnormalities: abnormal heartbeat, myocardial infarction, history of myocardial infarction, and normal cases. The developed model demonstrates a notable training accuracy of 97.34% and validation accuracy of 91.00%, showcasing its efficacy in disease classification. With the potential to save lives and reduce healthcare costs, this algorithmic approach offers a reliable, time-efficient alternative to manual diagnosis in detecting heart disorders, providing valuable support to medical professionals..
Impact of Tourism Entrepreneurship on Tourism Development among BRICS Countries
Authors: - M. Anbukarasi , - Manoshri N
Published: March 2024

This paper is the attempt to explore Tourism Entrepreneurship which is important to any country who makes higher revenue with the help of travel and tourister who makes arrangements for accommodation, food services, transport sector and purchasing power leads to some country wealthty in the world, so Tourism development is needed. In this study only (5 countries) BRICS countries have taken to measure impact of Tourism Development in Tourism Entrepreneurship among BRICS countries. Secondary data have taken for this study and panel data is the tool used for the study. According to analysis, There is significant impact between accommodation, transportation, employment, receipt, expenditure, inbound, outbound and domestic in BRICS countries.
Sarcome d’Ewing-like thoracique primitif révélé par un processus médiastino-pulmonaire associé à une pleurésie
Authors: - Hajar Arfaoui , - Soukaina Hallouli , - Meryem Zadi , - Nabil Bougteb , - Hasna Jabri , - Wiam El Khattabi , - Moulay Hicham Afif
Published: March 2024

Le sarcome d'Ewing-like est un type rare de sarcomes des tissus mous profonds qui peuvent se produire dans des sites inhabituels tel que la paroi thoracique et l’abdomen. Nous rapportons le cas d’une patiente âgée de 41 ans, exposée au tabagisme passif qui présentait depuis 1 mois une douleur thoracique droite associée à une dyspnée stade II Mmrc. L’examen clinique un syndrome d’épanchement liquidien de la moitié inférieure de l’hémithorax droit. La radiographie thoracique a objectivé une opacité de type pleural droite surmontée d’une autre opacité à projection hilaire. La TDM thoracique a montré un processus médiastino-pulmonaire droit associé à une pleurésie homolatérale. L’aspect du liquide pleural à la ponction pleurale simple était séro-hématique avec aux résultats de l’étude du liquide pleural un exsudat séro-hématique. Les trois ponctions biopsies pleurales étaient non spécifiques. Le dosage des marqueurs tumoraux ßHCG, αFP et ACE était négatif, la bronchoscopie souple a objectivé une inflammation à la limite du 1er degré diffuse avec quelques sécrétions muqueuses sans autres anomalies visibles et les biopsies bronchiques étaient non spécifiques. La ponction biopsie transpariétale a objectivé une prolifération tumorale maligne peu différenciée à cellules rondes très basophiles focalement avec CD95 positif évoquant un sarcome d’Ewing-like. Le bilan d’extension était normal. Après réunion de concertation multidisciplinaire le diagnostic final retenu a été un sarcome d’Ewing-like thoracique primitif métastatique à la plèvre, le traitement proposé était une chimiothérapie palliative.
Gender Justice in Education: A Peek into Indian Schools
Authors: - Mrinmayee Mandal
Published: March 2024

Understanding what gender justice stands for in education and how it can be implemented in schools with regard to India.
E-commerce: India's Business of the Future
Authors: - Mudasir Ahmad Parray
Published: March 2024

In India, the e-commerce business is expanding rapidly and shows no signs of slowing down. The introduction of smart phones, rising internet penetration, and shifting customer behavior are some of the factors propelling the growth of e-commerce in India. This paper examines the state of e-commerce in India now, highlights significant trends, talks about potential and problems, and offers predictions for the industry's future. The study's foundation is a thorough examination of scholarly works, business publications, and professional judgments.
A Study on ECOURT System of Sagar District of Madhya Pradesh
Authors: - Dr. Mukesh Kumar Chaurasia , - Anuva Ahluwalia
Published: March 2024

Receiving equitable treatment within the judicial framework is an inherent entitlement for all citizens of our country, within the framework of the constitution and laws laid down from time to time. However, the dispensation of justice is frequently prolonged due to the considerable backlog of cases in various tiers of the legal hierarchy. One of the significant reasons for this delay in justice is the citizen-to-judge ratio. With COVID in effect, the backlog of cases increased significantly, according to the NJDG census of 2023. To harness the momentum of technological advancements in the judicial sector. The e-court project was initiated in 2007. The objective of this project is to establish a justice delivery system through ICT, characterised by transparency, accessibility, efficiency, timeliness, and affordability, accessible to all citizens.
The focus of this research was to understand the workings and functioning of the e-court system at the District & Session Court of Sagar and to check the awareness of the judicial sector and general public about the e-court system. The study employed the descriptive research method to fulfil its objectives.
A Study on Khatu Shyam Temple Rajasthan
Authors: - Mr. Abhimannu saini , - Mr. Amit Kumar Mishra , - Mr. Khemchand Bairwa
Published: March 2024

According to Hindu religion, Khatu Shyam ji had received a boon from Shri Krishna in Dwaparyug that he would be worshiped by his name Shyam in Kaliyug. Barbarik ji's head was buried in Khatu Nagar (present-day Sikar district of Rajasthan state), hence he is called Khatu Shyam Baba. According to the story, a cow came to that place and was spontaneously releasing milk from her breasts every day. Later, after excavation, the head was revealed, which was handed over to a Brahmin for a few days. Once the king of Khatu Nagar was inspired in a dream to build a temple and to adorn that head in the temple. Subsequently a temple was constructed at that place and the head was decorated in the temple on the Ekadashi of Kartik month, which is celebrated as the birthday of Baba Shyam. The original temple was built in 1027 AD by Roop Singh Chauhan and his wife Narmada Kanwar. Abhay Singh, Dewan of Thakur, the ruler of Marwar, renovated the temple in 1720 AD on the instructions of Thakur. Khatu Shyam Ji Temple is located in Sikar district of Rajasthan and is considered one of the most important pilgrimage sites in the state. According to Hindu mythology , Khatu Shyam ji is the incarnation of Barbarik, son of Ghatotkach. It is said that devotees who chant his name with a true heart are blessed and their troubles go away , if they do so with true devotion.
Clinico-pathological Outcomes of Muscle Invasive Carcinoma Bladder in Post Neoadjuvant Chemotherapy Radical Cystectomy
Authors: - Prashant Pathania , - Amit Kishore , - Puneet Aggarwal
Published: March 2024

Background: Neoadjuvant chemotherapy (NAC) before radical cystectomy is advocated in patients with muscle invasive urothelial carcinoma of the bladder with the goal to improve survival by downstaging the primary tumour and eradicating micro-metastasis. The use of perioperative chemotherapy for bladder cancer, particularly in the neoadjuvant setting, remains limited. This study was designed to evaluate NAC plus RC regarding pathological response, perioperative morbidity and mortality outcomes.

Methods: This is a prospective and retro prospective study that was carried out from Jan 2018 to Jan 2020 for patients with muscle invasive bladder carcinoma. All patients having operable muscle invasive bladder carcinoma, Eastern Cooperative Oncology Group (ECOG) performance status 0–1 were included. Patients found to have metastatic disease, recurrent disease, patient not able to tolerate NAC were excluded from the study.

Results: Early complications occurred within 30 days after surgery & pathological response rates, perioperative morbidity, and mortality were compared.

Conclusions: A short course of neoadjuvant chemotherapy was associated to a low incidence of serious adverse events and did not increase the post-operative morbidity. Results suggest that non-urothelial tumour showed no response to Platinum based combination chemotherapeutic regimens. After NAC, residual local disease, persistent nodal disease and status of surgical margins are the most powerful prognostic factors for patients who underwent RC.
Addressing Social Inequality: Analysing the Impact of the Caste Disability Removal Act on Equality and Inclusion in Contemprory Society
Authors: - Aarwal Kaul
Published: March 2024

This paper looks at the suggestions of the Caste Incapacity Evacuation Act on social balance and incorporation in modern society. By utilizing a multidimensional approach, it examines the authentic setting, lawful system, and societal reaction to the Act. Through subjective investigation, it evaluates the Act's adequacy in tending to caste-based separation and advancing balance. The consider recognizes key challenges and openings for cultivating consideration and highlights the require for comprehensive arrangement measures to combat social disparity.
Public Relations New Trends on Disaster Management: Special Reference of Bihar
Authors: - Mr. Deepak Prasad , - Mr. Ashish kumar
Published: March 2024

India has been historically prone to natural disasters on account of its distinctive geo-climatic conditions. Floods, droughts, cyclones, earthquakes and landslides are perennial phenomena. The vulnerability in India is a lot compared to developed countries. this can be leading to vast losses in terms of human, financial, environmental and resource. At the worldwide level, there has been appreciable concern over natural disasters. when the state super cyclone and also the Bhuj earthquake, we tend to complete the necessity to adopt a multi-disciplinary and multi-sectoral approach and incorporate risk reduction within the development plans and methods. The new approach of the Government of India takes from the conviction that development cannot be done properly unless disaster mitigation is constructed into the event method. Disaster Management occupies a crucial place in this country's policy framework. This paper is to spotlight the disaster profile of Bihar and Disaster Management in Bihar.
Influencer Marketing Across Cultures: Strategies and Impact
Authors: - Dr. Pawan Pant
Published: March 2024

Influencer marketing has emerged as a key component of contemporary brand communication strategies because it provides exceptional chances to interact with a wide range of people across cultural divides. This study examines the subtleties of influencer marketing tactics used in diverse cultural contexts and assesses how they affect customer behavior and brand performance. We investigate how brands negotiate cultural variations, modify content, and choose influencers to effectively resonate with target audiences globally through a thorough analysis of the research and case studies. We also examine the moral and legal issues that arise when cross-cultural influencers work together. This paper offers practical insights for marketers looking to leverage influencer marketing in multicultural settings by examining growing trends and successful initiatives
Ayurvedic Management of Primary Infertility Due to Chocolate Cyst: A Case Report
Authors: - Ruchika Bhola , - Aishwarya M Vasava , - Prof. Shilpa B Donga , - Dr. Aishwarya M Vasava
Published: March 2024

Background: Endometriosis presents in three different entities, which are frequently found together: peritoneal lesions, deep endometriosis and ovarian endometriotic cysts (endometriomas) Ovarian endometrioma is a benign estrogen dependent cystic mass arising from ectopic endometrial tissue within the ovary. It contains thick, brown, tar like fluid, which may be referred to as a chocolate cyst. The presence of endometriomas indicates more severe stage of endometriosis. Endometriomas can lead to chronic pelvic pain and infertility, and often requires surgery for treatment. Endometriosis has been found in nearly 50% of women experiencing issues with infertility, and nearly 70% of women with pelvic pain. Classic symptoms includes dysmenorrhoea, dyspareunia, menorrhagia and infertility. Management of the ovarian cyst through surgery is available to meet urgent need of the patient, but to establish a satisfactory conservative medical treatment is the need of the hour. According to Ayurveda, depending upon most common symptoms it can be compared as a syndrome complex of Granthi, Vidradhi, Udavartini Yonivyapada, Paripluta yonivyapada and Vataja Yonivyapada. It is a Tridoshaja vyadhi with vitiation of Vata And Artava. Chocolate cysts can also be managed on the line of treatment of Granthi, (nodular/glandular swellings) Vidradhi (abscess), Raktapachana and Raktaprasadana. Aim: To manage Female infertility with chocholate cyst with shodhana and shamana therapy. Materials and methods: A patient aged 25years came to outdoor patient department of Prasutitantra Evum Streeroga with the complaint of lower abdominal pain and infertility since2 years. Her Ultrasonography report reveals bilateral chocolate cyst with no dominant follicle. She has tendency of formation of recurrent chocolate cyst since 3 years. She was administered Virechana after completion of menses on 1st cycle, Dashmoola Shodhan Basti along with Uttara Basti with uttarabasti with kasisadi taila and sahachara taila in 2nd cycle, Yastimadhu Ksheera Basti for 3rd cycle along with the Uttara Basti with kasisadi taila and sahachara taila, on the fourth month Uttarabasti with 5 ml of Dhanvantra taila was done, Shigru Patra Avagaha Swedana and Jeevaniya Choorna 3 gm orally with warm milk after Basti treatment. Results: Patient has marked reduction in the size of the chocolate cyst and she conceived with the treatment protocol of 4 months Conclusion: Above mentioned treatment plan has effective result due to Shothahara, Vatanulomana, Raktaprasadana properties which may have effectively curtailed the progress of ovarian cyst and helped in treating infertility.
Preservation of Cultural Heritage in Goa through Bhakti Literature and Artistic Expressions
Authors: - Devanand
Published: March 2024

Goa is home to a diverse collection of Bhakti literature and artistic works essential in safeguarding the area's cultural legacy. The cultural scene in Goa, characterised by elaborate temples with detailed carvings and moving music and dance performances, reflects the lasting influence of Bhakti traditions.
Important Diseases of Papaya in Andhra Pradesh
Authors: - Nagalakshmi, T. , - Sarada,G. , - Gopal, K. , - Sharat Kumar Reddy,Y.
Published: March 2024

Papaya (Carica papaya L.) stands as one of the most delectable fruits globally, flourishing primarily in tropical and sub-tropical climates. Despite its widespread cultivation, the potential yield and marketability of papaya are continually threatened by various diseases. The susceptibility of papaya to an array of fungal, viral, and bacterial infections, such as Phytophthora root rot, anthracnose, powdery mildew, stem end rot, black spot disease, papaya ring spot, and papaya leaf curl, has impeded commercial production on a global scale. Among these diseases, Papaya ring spot virus, Phytophthora foot rot and anthracnose, incited by Colletotrichum gloeosporioides Penz. emerging as the most important problems those directly affecting the economic yield. This article delves into a comprehensive exploration of the symptoms, epidemiology, and control measures associated with the predominant papaya diseases prevalent in India. Furthermore, it elucidates effective strategies and control measures that can be employed to mitigate the impact of these diseases, offering valuable insights to farmers, researchers, and stakeholders involved in papaya cultivation.
Sakta Cult through Art and Literature in Tamil Country
Authors: - Dr. A. Mahalingam , - Dr. C. Deepa
Published: March 2024

In the Sakta conception, the Mother Goddess is represented as Adisakti, the primordial energy, and the Supreme Being to who even the great gods like Brahma, Vishnu and Siva owe their origin, survival and destruction. This cosmic conception of the Mother Goddess is nothing but a development of the idea of a Mother deity who is supposed to represent the forces that stimulate the generative powers of nature. And again, the conception of a mother deity as the source of universal fecundity is also a development of an empiric notion which personifies the Mother Earth, the upholder of the human, animal and vegetable life which rests on her surface, into a benign goddess who is supposed to look over everything of this phenomenal world with motherly care and affection. Tamil society in the pre-modern period reveals interesting insights into the cult of Sakta and its historical information through an interrogation of the rich literary, inscriptional, art and architectural evidences.
DESTRUCTION OF ROCKS BY EXPLOSION DURING OIL TRANSPORTATION
Authors: Rafail Mehdiev, Alekber Mehdiyev Rafail Mehdiev, Alekber Mehdiyev , Vurgun Gakhramanov Vurgun Gakhramanov
Published: March 2024

When oil and gas wells are ready for operation, when drilling is carried out at the bottom of the well to establish contact with the formation, it is considered that the degree of crushing of the rocks is proportional to the speed of application of the load. As a result of the stresses created by them, the degree of fragmentation is higher. In the article, it is proposed to take into account the quality of crushing of the necessary rock by using some empirical coefficients in the calculation formulas. The dynamics of the rock dispersion process is studied on the basis of the hydrodynamic hypothesis. Here, the solution of the system of differential equations is given based on the fundamental laws of conservation of mass, energy and momentum. Based on the strength properties of mountain rocks, broken lines are found in the continuum of the whole environment, which determines the final effect of rock crushing. However, the accepted assumptions about the incompressibility of the rock and the transfer of the explosive impulse to the immediate environment significantly reduce the practical value of the results. It should be noted that in the immediate area directly adjacent to the load, the mountain rock is under uneven volume compression. In this case, the largest tangential stresses occur mainly in planes oriented at an angle of 450 to the radial direction. Thanks to this, a system of spiral sliding lines breaks the rock into small blocks. Outside this zone, a system of radial cracks is formed as a result of the expansion of the massif. When the pressure in the gas cavity decreases and the mass moves back in the direction of the load, tangential cracks appear. The combination of the volume compression zone and the reach zone constitutes the controlled crushing area. When the compression wave reaches the bare surface, it becomes a stress wave. As this wave travels from the surface to the load, it forms a system of jump cracks. The high explosive effect of explosive gases with sufficient explosion energy causes the release of such shattered rock. Obviously, this concept is very important for the development of the theory of explosive disintegration of mountain rocks. Because there is no unequivocal relationship between the nature of the dissolution of the rock and the acoustic hardness. One of the first to clearly describe the mechanism of shock wave formation and its transformation into a more explosive and seismic wave when detonation reaches the boundary of the charge cavity. In rocks, shock waves are formed during the entire time of expansion of the gas cavity. It explains in detail the mechanism of cracking phenomena by considering the cracks as a source of multiple reflections of the stress wave.
Keywords: rock strength, constant material, scale effect, rocks, destruction probability, fractured, robustness theory, microcrack, mineral, experience constant, density of defects, displacement, compression.
Minimalisasi Efek Suhu dan Kelembaban dalam Budidaya Jamur Tiram dengan Aplikasi Timer
Authors: Gultom Diana Astria , Kusuma Benz Edy
Published: March 2024

Pertanian merupakan kegiatan yang dihasilkan oleh masyarakat sebagai salah satu kunci dari swasembada pangan. Salah satu hasil pertanian yang dilakukan oleh masyarakat dalam penelitian ini ialah budidaya jamur tiram. Masyarakat melakukan budidaya jamur tiram untuk memenuhi kebutuhan hidupnya dalam mengonsumsinya sendiri dan atau untuk dijual kembali. Dalam pengelolaan budidaya jamur tiram, masyarakat menggunakan baglog sebagai media tanam substrat steril, sehingga bibit jamur tiram dapat diletakkan dan tumbuh. Untuk dapat tumbuh dalam baglog, selain karena media yang digunakan, faktor lainnya ialah tergantung pada kondisi lingkungan dengan keadaan kelembaban dan suhu tertentu. Maka dari itu, adapun aplikasi timer yang bernama Bardi Smart Plug Wifi Wireless untuk membantu merekayasa suhu dan kelembaban yang bisa diatur secara digital. Penggunaan aplikasi timer Bardi Smart Plug Wifi Wireless yang tentunya akan lebih efektif dan efisien. Selain itu, adanya penerepakan aplikasi Bardi Smart Plug Wifi Wireless juga untuk membantu penyemprotan air pada bibit jamur timur Metode yang digunakan ialah menggunakan rangkaian pipa penyemprotan air yang terkoneksi dengan Bardi Smart Plug Wifi Wireless, penggunaan CCTV yang menghadap hygrometer untuk pengawasan suhu dan kelembaban, dan penggunaan aluminium foil. Hasil dari penelitian ini ialah dengan cara meminta umpan balik dari petani mengenai aplikasi timer Bardi Smart Plug Wifi Wireless selama membantu proses budidaya jamur tiram, yang kemudian didapatkan pernyataan bahwa aplikasi tersebut mampu membantu budidaya jamur timur dalam kontrol pengairan. Kesimpulan yang didapatkan ialah jika dengan adanya penerapan aplikasi timer Bardi Smart Plug Wifi Wireless mengontrol pengairan secara otomatis dan secara periodik, sehingga mampu membuat biaya tenaga kerja bisa dikurangi.
Types of Grammatical Elements in Indonesian ELT Textbook: SFL Perspective
Authors: Hermawati Siti Puput , Santiana Santiana , Silvani Dea
Published: March 2024

Transitivity analysis is used to study news, reading, speeches, and other discourses. However, recent textbooks on grammatical element participants and processes have little transitivity analysis research. Teachers who understand transitivity analysis can help students understand grammar and improve their oral and written communication skills by developing grammar and using proper teaching methods to teach about sentence subjects and predicates.  This study seeks to identify the transitivity participants and processes that define grammatical elements in English for Nusantara for Grade 7. This study employed a textbook for qualitative content analysis. Subsequently, Halliday and Matthiessen's (2014) transitivity analysis is applied to the data. The types of participants found in this study were carrier (93 words), actor (79 words), senser (29 words), token (18 words), sayer (17 words), and behaver (8 words). Additionally, the relational processes (112 words) include attributing (94 words) and identifying (18 words), material processes (111 words), mental processes (32 words), verbal processes (18 words), existential processes (8 words), and behavioral processes (7 words). This study suggests that teachers employ transitivity to create activities and strategies to help students learn English grammar. It should assist students meet Merdeka Belajar curriculum goals, including speaking and writing English well. Keywords: Grammatical Elements, English Textbook, Systemic Functional Linguistics, Transitivity
The Impact of Problem-Based Learning (PBL) on School Nurses' Perception of Type 1 Diabetes, Learning Self-Efficacy, and Problem-Solving Skills
Authors:   Taegu Science University Defense Security Institute, Lee Jieun , Kim Min Jung
Published: March 2024

This study aimed to examine the impact of Problem-Based Learning (PBL) on the management of Type 1 diabetic students in enhancing school nurses' perception of Type 1 diabetes, learning self-efficacy, and problem-solving skills. It employed a single-group pretest-posttest quasi-experimental design. Fifty-eight school nurses participating in a job competency enhancement program at a university in D city were the subjects. Data were analyzed using SPSS/WIN 26.0, through frequency, percentage, mean and standard deviation, and paired t-tests. The results showed significant improvements post-education in perception of Type 1 diabetes (t=-3.54, p<.001), learning self-efficacy (t=-3.60, p<.001), and problem-solving skills (t=-6.89, p<.001). The study concludes that PBL is an effective teaching method for enhancing school nurses' competency in managing diabetic students. Future research should focus on developing diverse case-based learning modules and job competency enhancement programs for school nurses.
Networks and Events: A Curated Collection of Articles Published in Event Management
Authors: Rattenaa Vanessa , García-Fernández Jeronimo
Published: March 2024

This article examines the role of network-related research in event management studies. The reasons why networks are endemic in the event sector are stated with the goal of explaining why an event network theoretical framework is utilized in many studies. The change in topic and way
networks and events are described in the literature are discussed with the goal of explicating the main topics. This helps to understand how research on networks and events has evolved and changed based on environmental conditions. After analyzing the existing research primarily from the
Event Management journal on networks and events, future research suggestions are highlighted that aim to take into account emerging event conditions and technological trends.
The Impact of COVID-19 Pandemic on Vitiligo Patient Visits in Tertiary Hospital: A Retrospective Study
Authors: Rina Gustia  , Utama Redha Cipta
Published: March 2024

Background: Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of the population worldwide. The COVID-19 pandemic lockdown measures significantly affected the readiness of vitiligo patients to contact dermatologists. The aim of this study is to describe vitiligo patient visits during a pandemic situation.

Methods: A retrospective descriptive study, using secondary data obtained from Dr. M. Djamil General Hospital Padang medical records during the period of 2019–2021.

Results: During the pandemic (2020-2021), a total of 7 in 2020 and 19 in 2021 new vitiligo patient have been consulted. The ratio of male/female for two years was 16/10. The age of group 26-24 years had more frequently visited. A total 6 patients had segmental vitiligo and 16 patients had non segmental vitiligo. A total 4 patient had unstable vitiligo. During the pandemic, there were various vitiligo therapy such as oral and topical corticosteroid, topical immunomodulator, phototherapy, and punch grafting surgery. Compare to   before the pandemic situation in 2019, a total 25 new vitiligo patient have been consulted in our outpatient clinic. Compared to 2019, the number of visits decrease significantly 72% in 2020 and 24% in 2021.

Conclusion: The pandemic COVID-19 had an unprecedented impact on number of vitiligo patient visits to the tertiary hospitals. This condition may affect visits and patient compliance. There were significant reductions in the number of outpatient visits due to pandemic COVID-19.
Cytotoxic Activities and Expression of Protein p53 and Bcl-2 Extract and Fraction of Inggu Leaf (Ruta angustifolia [L.] Pers) to T47D Breast Cancer Cells
Authors: Ariasti Mia , Titik Sunarni  , Wiwin Herdwiani
Published: March 2024

Inggu leaves are plants that have been traditionally used as an alternative to cancer treatment. The aim of this study was to determine the cytotoxic activity of extracts, water fraction, ethyl acetate fraction and inggu leaf n-hexane fraction (Ruta angustifolia [L.] Pers) on T47D cells and to determine the effect of protein expression of P53 and Bcl-2 genes on inggu leaf active fraction (Ruta angustifolia [L.] Pers). Extract was obtained through maceration method with ethanol 96% solvent. Ethanol extract was then fractionated with liquid-liquid partition. Cytotoxic tests were performed using T47D breast cancer cells and Vero cells with the MTT assay test method and read the absorbance on ELISA reader. To determine the effect of expression of p53 and Bcl-2, an immunocytochemistry test was carried out. The results showed that the n-hexane extract and fraction of inggu  leaves had cytotoxic activity against T47D breast cancer cells with IC50 values of 54,210 and 84,118 µg/mL, while the fraction of water and ethyl acetate fractions had no cytotoxic activity with IC50 value > 100 µg / ml. Inggu  leaf extract (Ruta angustifolia [L.] Pers) is able to increase the expression of p53 and inhibit the expression of Bcl-2 at concentrations of 30,19-45,54 µg/mL and n-hexane fraction can increase the expression of p53 and can inhibit the expression of Bcl-2 at concentration 49,96-75,82 µg/mL.
Re-Fining Citrus Leaf and Fruit Spot Disease Control Options in Northern Uganda
Authors: Kumakech Alfred , Turyagyenda Laban F.
Published: March 2024

Citrus leaf and fruit spot disease, caused by Pseudocercospora angolensis has, since 2010, come about as the most dreadful disease of citrus in Northern Uganda. Over the last few years, feedback from citrus farmers has helped in re-fining management strategies. In the first years of citrus leaf and fruit spot disease outbreak in Northern Uganda, chemical treatment was promoted as part of a control package, in addition to the destruction of heavily diseased plants and buckthorn to remove inoculum. Buck horning and destruction of diseased plants is labour-intensive and time-consuming, especially when many infected citrus trees have to be taken out, or buck horned. Research findings indicate citrus leaf and fruit spot disease fungus can be weakened with fungicide sprays to the extent that even when disease symptoms are present on leaves, it does not automatically lead to infection of fruits. This gave rise to a new control strategy where only infected plants in an orchard are pruned, and all the citrus trees in the orchard are treated with fungicides. The pruning of visibly infected plants in an orchard will lessen the inoculum load, and the fungicide sprays will stop pathogen replication. This method is not labour intensive and takes less time when equated to severe buck horning of all the trees in the orchard. However, pruning and fungicide treatment need to move together with the control of new infections that can happen via unrestricted entry during harvesting
استخدام الموظفين لشبكات التواصل الاجتماعي وعلاقته بالرضا الوظيفي لديهم
Authors: محمد سالم بوسن د. سالم
Published: March 2024

هدفت هذه الدراسة الوصفية إلى معرفة مدى استخدام الموظفين لشبكات التواصل الاجتماعي وعلاقته بالرضا الوظيفي لديهم بمؤسسة ديوان المحاسبة الليبي  فرع بنغازي،حيث يتألف مجتمع الدراسة من كافة الموظفين العاملين بمؤسسة ديوان المحاسبة الليبي – فرع بنغازي، هذا وقد قام الباحث بتوزيع 124 استمارة استبانة باستخدام أسلوب المسح الشامل، اعتمد الباحث على المنهج الوصفي الكمي الذي يعد نوع من أساليب البحوث المسحية، وتوصلت هذه الدراسة لعدة نتائج من أبرزها الدور الفعال لشبكات التواصل الاجتماعي في تحسين الأداء الوظيفي بالمؤسسة والذي بدوره ينعكس بالإيجاب على تحقيق الرضا الوظيفي للموظفين بمؤسسة ديوان المحاسبة الليبي – فرع بنغازي، كما أظهرت النتائج قبول واضح من قبل الموظفين في الاعتماد على خدمات شبكات التواصل الاجتماعي لإنجاز الأعمال المناطه بهم، وسهولة وسرعة إنجاز المهام المتعلقة بالموظفين بمؤسسة ديوان المحاسبة الليبي –فرع بنغازي، وبناءً على تلك النتائج سرد الباحث جملة من التوصيات التي سوف تثري البحوث العلمية المستقبلية في هذا الحقل
Early prediction and prevention of infected pancreatic necrosis
Authors: Lv Cheng , Zhang Zi-Xiong , Ke Lu
Published: March 2024

Approximately 20%-30% of patients with acute necrotizing pancreatitis develop infected pancreatic necrosis (IPN), a highly morbid and potentially lethal complication. Early identification of patients at high risk of IPN may facilitate appropriate preventive measures to improve clinical outcomes. In the past two decades, several markers and predictive tools have been proposed and evaluated for this purpose. Conventional biomarkers like C-reactive protein, procalcitonin, lymphocyte count, interleukin-6, and interleukin-8, and newly developed biomarkers like angiopoietin-2 all showed significant association with IPN. On the other hand, scoring systems like the Acute Physiology and Chronic Health Evaluation II and Pancreatitis Activity Scoring System have also been tested, and the results showed that they may provide better accuracy. For early prevention of IPN, several new therapies were tested, including early enteral nutrition, antibiotics, probiotics, immune enhancement, etc. , but the results varied. Taken together, several evidence-supported predictive markers and scoring systems are readily available for predicting IPN. However, effective treatments to reduce the incidence of IPN are still lacking apart from early enteral nutrition. In this editorial, we summarize evidence concerning early prediction and prevention of IPN, providing insights into future practice and study design. A more homogeneous patient population with reliable risk-stratification tools may help find effective treatments to reduce the risk of IPN, thereby achieving individualized treatment.
Diseases of bile duct in children
Authors: Eiamkulbutr Sutha , Tubjareon Chomchanat , Sanpavat Anapat , Phewplung Teerasak , Srisan Nimmita , Sintusek Palittiya
Published: March 2024

Several diseases originate from bile duct pathology. Despite studies on these diseases, certain etiologies of some of them still cannot be concluded. The most common disease of the bile duct in newborns is biliary atresia, whose prognosis varies according to the age of surgical correction. Other diseases such as Alagille syndrome, inspissated bile duct syndrome, and choledochal cysts are also time-sensitive because they can cause severe liver damage due to obstruction. The majority of these diseases present with cholestatic jaundice in the newborn or infant period, which is quite difficult to differentiate regarding clinical acumen and initial investigations. Intraoperative cholangiography is potentially necessary to make an accurate diagnosis, and further treatment will be performed synchronously or planned as findings suggest. This article provides a concise review of bile duct diseases, with interesting cases.
Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
Authors: Gravina Antonietta Gerarda , Panarese Iacopo , Trotta Maria Consiglia , D'Amico Michele , Pellegrino Raffaele , Ferraraccio Franca , Galdiero Marilena , Alfano Roberto , Grieco Paolo , Federico Alessandro
Published: March 2024

BACKGROUND

Melanocortin 3 and 5 receptors (i.e., MC3R and MC5R) belong to the melanocortin family. However, data regarding their role in inflammatory bowel diseases (IBD) are currently unavailable.

AIM

This study aims to ascertain their expression profiles in the colonic mucosa of Crohn’s disease (CD) and ulcerative colitis (UC), aligning them with IBD disease endoscopic and histologic activity.

METHODS

Colonic mucosal biopsies from CD/UC patients were sampled, and immunohistochemical analyses were conducted to evaluate the expression of MC3R and MC5R. Colonic sampling was performed on both traits with endoscopic scores (Mayo endoscopic score and CD endoscopic index of severity) consistent with inflamed mucosa and not consistent with disease activity (i.e., normal appearing mucosa).

RESULTS

In both CD and UC inflamed mucosa, MC3R (CD: + 7.7 fold vs normal mucosa, P < 0.01; UC: + 12 fold vs normal mucosa, P < 0.01) and MC5R (CD: + 5.5 fold vs normal mucosa, P < 0.01; UC: + 8.1 fold vs normal mucosa, P < 0.01) were significantly more expressed compared to normal mucosa.

CONCLUSION

MC3R and MC5R are expressed in the colon of IBD patients. Furthermore, expression may differ according to disease endoscopic activity, with a higher degree of expression in the traits affected by disease activity in both CD and UC, suggesting a potential use of these receptors in IBD pharmacology.
Reproductive Indicators of Nasczokin’s Lime (Tilia nasczokinii Stepanov)
Authors:   Sukachev Institute of Forest of the Siberian Branch of the RAS, Sedaeva Mariya I. , Ekart Aleksandr K. , Kravchenko Anna N.
Published: March 2024

Tilia nasczokinii Stepanov (Naszokin’s lime) is endemic to the south of the Krasnoyarsk Territory and is of relict origin. Two of its populations grow in the vicinity of Krasnoyarsk on the left and right banks of the Yenisey River, being a part of pine forests and mixed pine-deciduous herb forests. The total number of the species is about 500 plant units, of which only 43 plants are currently bearing fruit. This research has determined the sizes and qualitative characteristics of T. nasczokinii fruits and seeds. The lime-capsules of T. nasczokinii, for 2 populations in general, have had the length of 5.7 ± 0.026 mm and the width of 5.0 ± ± 0.017 mm. The seeds have had the length of 3.6 ± 0.019 mm and the width of 2.9 ± 0.015 mm. It has been established that the lime-capsules in the left bank population are characterized by an elongated pear-shaped form, while in the right bank population the lime-capsules are spherical and slightly pointed at the top. In terms of the size of lime-capsules and seeds, T. nasczokinii did not differ statistically from the introduced T. cordata, which grows in the plantation under similar environmental conditions. In the left bank population, the masses of lime-capsules (18.3 g/1000 pcs.) and seeds (11.9–12.7 g/1000 pcs.) have turned out to be noticeably less than in the right bank population (lime-capsules – 24.8–29.9 g/1000 pcs., seeds – 16.1–18.0 g/1000 pcs.). In the left bank population, up to 60 % of the lime-capsules have been seedless and up to 43 % of the seeds have been empty. Seed viability has been equal to 17–32 %.In the right bank population, most of the lime-capsules have contained seeds (up to 91 %), and the proportion of empty lime-capsules has been small (up to 18 %). Seed viability has been equal to 66–83 %. Field germination of the seeds has been equal to 9.2 % (for some trees – up to 10.5 %) in the left bank population and 12.2 % (up to 21.1 %) in the right bank population. Despite the low field germination of the seeds in both populations, it is possible to obtain seed planting stock for creating artificial plantings of T. nasczokinii in order to preserve and restore the population of this rare relict species in the south of Central Siberia.
STUDIES OF PSYCHOLOGISTS ON THE FORMATION OF WILL
Authors:   Professor, Doctor Of Psychology At The ", Taskaraevna Nishanova Zamira ,   Applied Psychology",   Department At TSPU, Uzbekistan
Published: March 2024

The article provides a theoretical analysis of the views of various psychologists about will. There is also a set of exercises for forming the will in students of junior school age.
ANALYSIS OF THE PRACTICE OF ATTRACTING FOREIGN INVESTMENTS THROUGH THE FUND MARKET
Authors:   Tashkent Institute of Finance, Valuation work and Independent Researcher of the Investment Department, Ph.D, Uzbekistan, Khoshimov Jakhongir R.
Published: March 2024

The article examines the meaning of the stock market and the definitions of local economists. Also, the practice of attracting foreign investments through the stock market has been analyzed. The dynamics of investments in securities and the composition of investors investing in sovereign Eurobonds of Uzbekistan were studied. The volume of investments in the US stock market was analyzed. Proposals and recommendations for attracting foreign investments through the stock market have been developed.
THE USE OF MECHANISMS OF PUBLIC-PRIVATE PARTNERSHIP IN THE FORMATION OF ENVIRONMENTAL INFRASTRUCTURE
Authors:   Tashkent Institute Of Irrigation And Agricultural Mechanization Engineers, ", Ibragimovna Xodjimuxamedova Shaxida ,   National Research University",   , Associate Professor Of The Department Of ",   Accounting And Auditing",   , Faculty Of ",   Economy",   , Uzbekistan, Kamalovna Arashova Sabina ,   Tashkent Institute Of Irrigation And Agricultural Mechanization Engineers, “National Research University”, Student Of The Faculty Of “Economy”, “Accounting And Audit”, Uzbekistan
Published: March 2024

The public-private partnership project should be carried out with the inclusion of socio-economic tasks i.e. the tasks of protecting the environment, ensuring environmental desolation and rational use of Natural Resources. The establishment of PPP in the environmental sphere in our country and a wider understanding of the goals of PPP.
DIRECTION FOR IMPROVING THE ORGANIZATIONAL AND INSTITUTIONAL FRAMEWORK OF PUBLIC-PRIVATE PARTNERSHIP
Authors:   Doctoral student of Tashkent State Law University, Uzbekistan, ugli Aminov Mirobbos Askar
Published: March 2024

The introduction of modern mechanisms of public-private partnership in our country on the basis of mutually beneficial cooperation is one of the important priorities in the Action Strategy for the development of the Republic of Uzbekistan. Despite the existence of a clear and well-developed strategy for the development of the country, there are insufficient organizational and legal mechanisms for the implementation of the tasks set by some executive authorities, duplication of tasks and excessive state regulation has a negative impact on the effectiveness of ongoing reforms.
GUARANTEES OF FREEDOM OF SCIENTIFIC CREATIVITY IN THE NORMS OF INTERNATIONAL LAW
Authors:   Lecturer Of Department Of Constitutional Law Of Tashkent State University Of Law, Uzbekistan, Olimovna Aslonova Laylo
Published: March 2024

The article examines the consolidation and development in the law "On Science and Scientific activity" of the internationally recognized human right to freedom of scientific research. The article analyzes the normative content of freedom of science and its reflection in legislation of Uzbekistan. Much attention is paid to the issue of the correlation of freedom of science with a number of civil, social and economic human rights, the beneficiaries of which are also scientists and scientific and technical workers. It is concluded that it is necessary to establish a balance between freedom of scientific research and human rights due to the increasing risky nature of modern scientific and technological progress.
GENRE PECULIARITIES OF RAZIA TUJJAR'S SHORT STORIES
Authors:   Doctor of Philological Sciences, Associate Professor, International Islamic Academy of Uzbekistan, Tashkent, Uzbekistan, Turdiyeva Oydin Zafardinovna
Published: March 2024

After the Islamic Revolution of 1979, which ended the king's reign of two centuries, changes took place in the socio-political and spiritual-cultural life of the country. These changes also had an impact on Iranian literature. While on the one hand, in the first years after the revolution, these changes manifested themselves in the strengthening of the principles of Islamisation of cultural and spiritual life, in the last decades the writers' work has been moving away from these foundations, the desire for new themes, formal and stylistic explorations, and the desire to describe reality in a new way have become stronger.
Designing Mail Server Using Exchange Server At SMPN 17 Bengkulu City
Authors: Sari Amelia Purnama , Kanedi Indra , Aspriyono Hari
Published: March 2024

Mail server is one of the most widely used server functions in a school or other company. This is because the email function itself can reduce the cost of correspondence using paper, is faster and more efficient than manual communication and uses attachments that are useful as complements and additional documents related to the contents of the email. Mail Server implementation is done offline by installing on a server that has been prepared. There are 2 operating systems that will be used in the implementation of this mail server, namely for the server (Windows Server 2012) and for the client (Windows 10). The mail server uses Exchange Server 2010 installed on the server (Windors Server 2012). In its application using wireless router with 1 laptop will be used as a server and 2 client laptops, so that the results of the shipment that will be sent to the recipient are automatically stored on the server. While the client accesses the message reception and sends the message. Based on the tests that have been done, if you enter the appropriate username and password, you can enter mail so you can send messages or receive messages from the server to the client and the system is able to send or reply emails from one account to another.
Decision Support System Appointment Of Permanent Employees With Analytical Hierarchy Process Method
Authors: Kurniawan M. Ajis Akbar , Siswanto, Siswanto, , Fredricka Jhoanne
Published: March 2024

The appraisal system for the appointment of training employees to permanent employees at Rakyat Bengkulu Television (RBTV) has not been computerized and is still done manually through an assessment form that has been provided to give each training employee a score that has been seen for the last 3 months. This takes a long time to find out who is eligible to be appointed as permanent employees. The Decision Support System for the appointment of permanent employees at the Bengkulu Rakyat Televisi (RBTV) Bengkulu was made using the Visual Basic .Net programming language and SQL Server 2008r2 database, where in the application one of the Decision Support System Methods, namely Analytical Hierarchy Process (AHP) has been applied. This Decision Support System for the appointment of permanent employees at the Bengkulu Rakyat Televisi (RBTV) Bengkulu can assist the employee appraisal process and provide recommendations for those who are eligible to be appointed as permanent employees. As for the test results in 2018 using the AHP Method, it was found that 3 employees had the highest scores out of 10 employees, namely Galeh Fajar (87.81), Retno Setiawan (85.57), and Richo Rieo (85.5).