bluuebunny/crossref_metadata_2025 huggingface dataset:
HTA Reshaping: Rethinking the Health Technology Assessment Framework in Portugal
Authors: Pereira João , Alves Joana , Rodrigues Bernardo , Caetano Ricardo , Brito-Cruz Pedro  , Sousa Joana , Barata Branca
Published: June 2021

Introduction: Health technology assessment (HTA) aims to provide decision makers with relevant data to make informed choices. Recent changes in the Portuguese HTA framework have altered substantially the assessment methodology with regard to economic evaluation, with potential impacts on access and process efficiency. The HTA Reshaping Project had as its main objective informing the debate on HTA in Portugal, thereby identifying improvement opportunities and solutions to the HTA framework that address future challenges. Methods: The project comprised several phases, i.e., (1) mapping and evaluation of different HTA frameworks across Europe, identifying best practices and key variables to consider in future frameworks; (2) conduction of in-depth interviews with relevant stakeholders (n = 11); and (3) development of 2 workshops – one with young professionals (n = 12) and another with relevant HTA stakeholders (n = 19) – to consolidate and further explore vital elements of HTA, aimed at brainstorming ideas and developing solutions to improve some of the most critical points, with a view to addressing future challenges. Results: The comparison of HTA frameworks showed that their purpose and sophistication vary across European countries. For example, the need for economic evidence is not unanimous, and reimbursement agreements vary considerably. Among the stakeholders interviewed there was a high level of agreement on priorities that should be addressed, e.g., expanding and creating national level registries and assuring patient participation throughout the HTA process. The possibility of using managed entry agreements to enhance patients’ access, applying multi-indication pricing for medicines with different therapeutic values per indication, and improvement of registry/system interoperability gathered a moderate level of agreement. Conclusions: The Portuguese HTA framework might be further adapted to upcoming challenges and should evolve to improve access to innovative therapies. There is still a long path towards the convergence of HTA frameworks in EU member states.
Nicht kleinzelliges Lungenkarzinom: Die Rolle immunassoziierter unerwünschter Ereignisse im Hinblick auf die Prognose und Wirksamkeit bei Patienten unter Immuntherapie
Authors: Horter Susanne , Schütte Wolfgang
Published: June 2021

Purpose: The development of immune-related adverse events (irAEs) in patients undergoing immunotherapy has been reported to be a favorable prognostic factor in several studies. We aimed to examine the correlation between irAEs and prognosis in patients with non-small cell lung cancer (NSCLC) and further reveal the patient characteristics associated with response to immunotherapy among treatment responders who developed irAEs. Methods: We retrospectively enrolled 80 patients with NSCLC who received immunotherapy at Shinshu University Hospital between February 2016 and February 2020. Progression-free survival (PFS) and overall survival (OS) were compared between patients with and those without irAEs. We examined the prognostic factors associated with PFS and OS using univariate and multivariate Cox proportional-hazards models. We further analyzed the patients who developed irAEs by classifying them into responders and non-responders. Results: Twenty-five patients developed irAEs. The median PFS and OS of the patients with irAEs were significantly longer than those of the patients without irAEs (6.8 vs. 1.9 months, p < 0.001, and 37.8 vs. 8.1 months, p < 0.001, respectively). Multivariate analysis associated with PFS and OS indicated that the development of irAEs was an independent favorable prognostic factor. Among the patients developing irAEs, the responder group had a significantly higher incidence of multiple irAEs than the non-responder group (41.7 vs. 0.0%, p = 0.009). Conclusion: Our findings revealed that the development of irAEs was associated with clinical benefits in NSCLC patients who received immunotherapy. In particular, patients with multiple irAEs might have good prognoses.
Lower Limb Dynamic Activity Significantly Reduces Foot Skin Perfusion: Exploring Data with Different Optical Sensors in Age-Grouped Healthy Adults
Authors: Florindo Margarida , Nuno Sérgio Loureiro , Rodrigues Luis Monteiro
Published: June 2021

Introduction: The human lower limb is widely used as a model to study in vivo microcirculatory physiology and pathophysiology. It is a preferential target for critical comorbidities (overweight, diabetes, and peripheral vascular disease). Movement and activity are consistently regarded as beneficial, but the related adaptive physiology is still poorly understood. Our goal was to better identify the foot microcirculatory changes after a regular walking gait activity in healthy subjects of different ages. Methods: Twelve healthy participants of both sexes, with normal BMI and Ankle-Brachial Index, were selected and grouped according to age – group I (21.0 ± 1 y.o.) and group II (55.8 ± 3 y.o.). The protocol involved 2 phases of 5-min duration each – phase 1, a static standing position, and phase 2, 5-min walking with a comfortable pace on a pre-established circuit. Perfusion changes were assessed in the dorsal region of both feet before (baseline, phase 1) and after (phase 2) the gait period by noninvasive optical technologies – laser Doppler flowmetry (LDF), photoplethysmography, and polarized spectroscopy (PSp). Comparative statistics were performed with a 95% confidence level. Results: All instruments detected an asymmetric nonsignificant perfusion between right and left feet during rest in all participants with values in females consistently lower than men. Older participants exhibited lower baseline values than the younger group. Gait evoked a perfusion reduction in all participants relative to phase 1 detected with all technologies, with statistically significant changes recorded with LDF (group I, p = 0.033, and group II, p = 0.028) and PSp (group II, p = 0.041). Furthermore, LDF revealed that gait significantly reduced perfusion velocity in the older group (p = 0.003). Corresponding changes in the younger group were present but discrete. Recovery to baseline levels was also slower in the older group. Discussion/Conclusions: Our results confirm that perfusion is age dependent and demonstrate the clinical relevance of simple dynamic activities such as gait. This reduction of the dorsal foot perfusion occurs in depth, being more pronounced with the movement intensity, suggesting a wide application potential in early diagnostics as for rehabilitation.
РЕЗУЛЬТАТИ ГІСТОЛОГІЧНОГО АНАЛІЗУ ТРОМБІВ, ОТРИМАНИХ ПІД ЧАС ПЕРКУТАННОГО КОРОНАРНОГО ВТРУЧАННЯ: МОРФОЛОГІЧНІ ТА КЛІНІЧНІ ПАРАЛЕЛІ
Authors: Гребеник М. В. , Жегестовська Д. В. , Небесна З. М. , Крамар С. Б.
Published: June 2021

В основі патогенезу гострого коронарного синдрому лежить дестабілізація атеросклеротичної бляшки із подальшим тромбозом коронарної артерії. Із введенням у клінічну практику перкутанних коронарних втручань з’явилася можливість не лише швидко та ефективно відновлювати прохідність інфаркт-залежної судини, а й прижиттєво досліджувати структуру коронарних тромбів. Ця інформація є цінною як для поглиблення розуміння патогенезу гострих коронарних подій, так і для прогнозу їх подальшого перебігу.
Мета – зіставити клінічні дані та гістологічну структуру тромбів у пацієнтів з гострим інфарктом міокарда (ГІМ).
Матеріал і методи. У дослідженні взяли участь 109 пацієнтів із діагнозом ГІМ. Придатний для гістологічного дослідження матеріал було отримано в 12 випадках. Відповідно до цього проводили аналіз зразків із визначенням гістологічного віку аспірованих тромбів, а також зіставлення їх морфологічних характеристик та клінічних даних пацієнтів.
Результати. У більшості випадків аспіровані тромби за макроскопічними показниками були віднесені до групи «червоних» – n=10 (83,3 %). «Білі» тромби траплялися рідше – у 2 (16,7 %) випадках, і були отримані лише у разі тривалості больового синдрому менше 2 годин. За даними світлової мікроскопії у 3 (25,0 %) випадках тромби класифікувалися, як «свіжі», всі вони були отримані в перші 6 годин з моменту розвитку больового синдрому. «Літичні» тромби виявлено у 7 (58,3 %) пацієнтів і у 2 (16,7 %) зразках відмічалися ознаки, характерні для «організованих» тромбів. При оцінці віддаленого прогнозу лише в одному випадку був епізод повторної госпіталізації з приводу повторного інфаркту міокарда у пацієнта із «червоним» тромбом, що за результатами світлової мікроскопії був віднесений до групи «літичних», тобто віком від 1 до 5 днів, незважаючи на тривалість періоду «сипмтом-балон» близько 3 годин.
Висновки. Нами було виявлено невідповідність гістологічного та клінічного віку коронарних тромбів. Також вдалося попередньо підтвердити існування зв’язку між структурою аспірованих тромбів та потенційним прогнозом перебігу гострого інфаркту міокарда, в тому числі й розвитку ускладнень у далекій перспективі.
PARTICULARITIES OF DISTANCE LEARNING OF FOREIGN STUDENTS IN A PANDEMIC COVID-19
Authors: Yushchenko L. O. , Tykholaz O. V. , Oliinyk V. S.
Published: June 2021

Advantages and disadvantages of distance learning at the Department of Propaedeutic Pediatrics of M. Pyrohov Vinnytsia National Medical University were assessed. Students′ attitudes to distance learning was analyzed. Most of foreign students were satisfied with the educational process at the Department of Propaedeutic Pediatrics. On the one hand, they have enumerated lots of advantages, the most important of them are staying safe and interruption of infections spreading, comfortable and convenient learning, saving a lot of time, reduction stress and tiredness. On the other hand, distance learning has disadvantages. Distance learning at medical universities are having theoretically classes mainly without practical and communicative skills at the patient’s bedside. The main barrier of remote learning is the quality of internet connection. Active communication, interaction, getting feedback, understanding the needs and feelings of students are significant during remote studying.
ОСОБЛИВОСТІ ОРГАНІЗАЦІЇ НАВЧАЛЬНОГО ПРОЦЕСУ В УМОВАХ ПАНДЕМІЇ COVID-19 НА КАФЕДРІ ФАРМАКОЛОГІЇ З КЛІНІЧНОЮ ФАРМАКОЛОГІЄЮ ТЕРНОПІЛЬСЬКОГО НАЦІОНАЛЬНОГО МЕДИЧНОГО УНІВЕРСИТЕТУ ІМЕНІ І. Я. ГОРБАЧЕВСЬКОГО МОЗ УКРАЇНИ
Authors: Лой Г. Я. , Іванків Я. І. , Лойко І. І. , Олещук О. М.
Published: June 2021

Пандемія COVID-19 стала найбільшим викликом, з яким стикнулися учасники різних рівнів навчального процесу в усьому світі. Запровадження карантину на території України із забороною відвідування здобувачами закладів освіти викликало необхідність організувати навчальний процес он-лайн у надзвичайно короткий термін із врахуванням унікальності потреб для кожного предмета. Це кардинально змінило підходи до викладання дисциплін, для яких такий формат не був типовим, і стало нелегким випробуванням як для викладачів, так і студентів, адже вимагало дуже високого рівня організованості обох сторін. З такими труднощами зіткнулися учасники навчального процесу Тернопільського національного медичного університету імені І. Я. Горбачевського МОЗ України, проте дистанційна форма занять була опанована досить швидко, що дозволило забезпечити хороший рівень підготовки здобувачів освіти. У даній статі розповідається про досвід викладання предмета «Фармакологія» на кафедрі фармакології з клінічною фармакологією в умовах карантинних обмежень, зумовлених пандемією COVID-19, описуються засоби комунікації, інноваційні технології та методики викладання дисципліни, що застосовуються для організації навчального процесу в режимі он-лайн. Дистанційна модель навчання сприяла розвитку інтерактивних методів обговорення матеріалу та оцінювання знань. Проте великим недоліком такого формату є нижча об’єктивність оцінювання знань студентів у зв’язку із можливістю застосування ними додаткових матеріалів під час семінарської частини заняття та тестового контролю. Хоча і студенти, і викладачі кафедри фармакології з клінічною фармакологією були змушені стикнутися з різноманітними проблемами, які вимагали швидкої адаптації до змін, однак, врешті, вдалося забезпечити високу якість навчального процесу.
PERSPECTIVES AND ISSUES OF TEACHING “OCCUPATIONAL HEALTH AND SAFETY” FOR PHARMACEUTICAL DEPARTMENT GRADUATES
Authors: Budniak L. I. , Pokotylo O. O.
Published: June 2021

An important component of training a specialist in any specialty is the formation of systematic knowledge of health and safety, life protection, the legal basis of relations between employer and employee in the implementation of his rights about healthy and safe working conditions. Nowadays, there has been a sweeping trend to a significant decreasing the auditorium hours of occupational safety, that prompted us to analyze the problematic issues and the creation of prospects for improving teaching of this discipline.

The aim of the study was analysis of teaching issues, justification of the expediency and the importance of training the discipline “Occupational Health and Safety” for future specialist in Pharmacy (Industrial pharmacy) and formation of proposals about ways to improve education approaches.

The article highlights the relevance of the study of pharmaceutical department students the discipline “Occupational Health and Safety”. According to the current problems and the global transition to a mixed form and e-learning in higher education establishments it’s noted the importance of changes in the organization of training. The psychosomatic features of students in the transition to distance learning are analyzed.

It is established that in today’s conditions the training of the future specialist with the appropriate awareness of safety situations is one of the most important areas of his professional education. For creating a systematic students’ understanding and consciousness, it’s necessary teaching discipline “Occupational Health and Safety”on the high scientific and technical level, with sufficient quantity of auditorium hours, applying various forms, means, techniques and innovative methods of e-learning activities with an accent on dual education. Special attention should be paid to inspection nand boosting in knowledge of regulatory and legislative acts, because of ignorance or violation of the law does not exempt a person from the responsibility.
ПЕРСПЕКТИВИ ВДОСКОНАЛЕННЯ НАВЧАЛЬНОГО ПЛАНУ ДЛЯ ІНТЕРНАТУРИ З ФАХУ «СТОМАТОЛОГІЯ» У РОЗДІЛІ «ЗАХВОРЮВАННЯ ТКАНИН ПАРОДОНТА»
Authors: Писаренко О. А. , Удальцова-Гродзинська К. О. , Шинкевич В. І.
Published: June 2021

Розділ навчального процесу з теми «Захворювання пародонта» потребує негайної ревізії, оскільки застарілі концепції призвели до нерозуміння і неможливості публікацій наукових статей у міжнародних рецензованих виданнях, що відкидає у минуле вітчизняну стоматологічну науку. Аналіз основних положень розділу навчального процесу з теми «Захворювання пародонта» шляхом їх порівняння із концепціями нової класифікації періодонтальних та періімплантних захворювань і станів 2017 р. показав обґрунтовану коректність терміна «періодонтит» замість «пародонтит», визначив етіологію й основні риси патогенезу періодонтиту, обґрунтував необхідні методи і перелік диференційних діагнозів, та розсортував комплексне лікування на чіткі фази, етапи і відповідність до складності пародонтиту. Некротизуючі захворювання тканин пародонта, екстремальні стани з рецесією діагностуються за іншими схемами, ніж періодонтальні індекси. Періімплантні стани органічно поєднані з іншими захворюваннями пародонта, оскільки обумовлені наявністю біоплівки або місцевими факторами. Отже, імплементація класифікації періодонтальних та періімплантних захворювань і станів Американської академії пародонтології (AAP) та Європейської федерації пародонтології (EFP) 2017 р. сприяє  сучасному розумінню їх етіології та патогенезу, дозволяє уніфікувати підходи до діагностики, лікування, моніторингу, прогнозування і профілактики, а отже, є  необхідними для вивчення.
ФОРМУВАННЯ ТЕРМІНОЛОГІЧНОЇ ГРАМОТНОСТІ МАЙБУТНІХ МЕДИКІВ НА ОСНОВІ ЕТИМОЛОГІЧНОЇ ХАРАКТЕРИСТИКИ КЛІНІЧНИХ ТЕРМІНІВ З ХІМІЧНИМ КОМПОНЕНТОМ
Authors: Паласюк Г. Б. , Паласюк Б. М.
Published: June 2021

У статті розглянуто особливості формування термінологічної грамотності майбутніх медиків, з’ясовано значення етимологічної характеристики клінічних термінів у формуванні їх термінологічної компетентності. У дослідженні наголошено, що твірною основою великої групи багатокомпонентних латинських клінічних термінів служить найменування хімічного елемента. Встановлено, що серед клінічних термінів-композитів переважну більшість становлять терміни, які є похідними номінативними одиницями, а основним дериваційним процесом ‒ суфіксація. Показано, що визначальною ознакою термінологічних суфіксів, продуктивних у клінічній терміносистемі, є наявність семантичного значення, притаманного саме для медичної галузі. У процесі дослідження охарактеризовано структуру термінів-композитів із хімічним компонентом, які включені у медичні словники УЛАМЕС у чотирьох томах, до двотомного ілюстрованого медичного словника Дорланда і навчально-наукового посібника «Клінічна латина з англійськими та українськими відповідниками». З’ясовано, що більшість клінічних термінів-композитів із хімічним компонентом утворена за допомогою приєднання до основи назви хімічного елемента суфіксів -ismus (у значенні «хімічне отруєння»)  та -osis  (назви професійних нозологічних одиниць, які вказують на хронічне захворювання, викликане тривалим вдиханням пилу хімічного елемента). Акцентовано, що саме терміносистеми складають основу професійної мови лікаря, тому знання етимології й значення найчастіше вживаних як латинських, так і грецьких терміноелементів, які визначають зміст терміна, сприяють не тільки кращому їх запам’ятовуванню, а й фахово грамотному використанню у практичній чи науковій діяльності як в усній, так і у письмовій формах.
A litertura que Stálin proibiu
Authors: Andrade Homero Freitas de
Published: June 2021

Eram os tempos da NEP1. Exaurida ao fim da guerra civil que se abatera sobre todo o território russo durante os últimos três anos (1918- 1921), minguando ainda mais as já historicamente precárias condições de sobrevivência do povo, agravadas também pelo comunismo de guerra instituído logo depois de Outubro, a Rússia encontrava-se num beco sem saída. Nas grandes cidades, alimento e moradia eram os problemas cruciais. A fome consumia a jovem República. Em agosto, por não ter como seguir a receita do médico, que lhe tinha recomendado uma dieta à base de açúcar, milho, leite e limão, o poeta A.Blok morrera de inanição em Petrogrado. Quase um ano depois, seria a vez de Velimír Khlébnikov, o grande inspirador do cubo-futurismo, partir desta, faminto e doente em Moscou. Como eles, milhares de pessoas.
A educação no judaísmo
Authors: Szpiczkowski Ana
Published: June 2021

Para se falar de educação no judaísmo, é importante entendê-la dentro de um contexto mais amplo, que envolve a concepção de mundo, a inser- ção do homem nele e a compreensão que se tem do homem enquanto agente. A educação, ao longo dos tempos, tem sido percebida sob diferentes prismas, dependendo da cultura à qual está vinculada, e isso porque cada povo possui princípios norteadores relacionados ao seu desenvolvimento educacional.
Almada negreiros e o futurismo russo: intersecções
Authors: Cavaliere Arlete O.
Published: June 2021

O presente artigo procura estabelecer as relações e as implicações estéticas dos movimentos que constituem as vanguardas russas no trabalho artístico de Almada Negreiros.
Sobre a Estética de Okashi na Tradução de O Livro-Travesseiro de Sei Shônagon
Authors: Cordaro Madalena N. H.
Published: June 2021

O presente trabalho visa a discutir a conceituação estética de okashi, termo-chave na história da literatura japonesa, em referência particularmente ao período Heian (794-1192), na obra Makura-no Sôshi (O Livro-Travesseiro) da dama da corte Sei Shônagon. Trabalho coletivo do Centro de Estudos Japoneses da USP, as discussões aqui desenvolvidas são frutos de encontros semanais, com uma redação resultante de pesquisa e reflexão individuais da autora, mas com anuência dos tradutores envolvidos.
O papel de tradução no desenvolvimento da estruturação da arte literária armênia
Authors: Yeghiazaryan Lusinê
Published: June 2021

O objetivo deste artigo é discutir a importância das traduções no processo de desenvolvimento e estruturação da literatura armênia. Aten- ção especial é dada à expansão lingüística e geográfica da atividade de tradução.
Implicações linguísticas da tradução de textos clássicos - o caso de Agnon
Authors: Langer Eliana R.
Published: June 2021

Nesse trabalho focalizo a obra de Agnon para fazer uma reflexão acerca da questão de estilo e linguagem na tradução de textos literários clás- sicos. Sua obra foi escrita numa linguagem particular que constitui ao mes- mo tempo um elemento de encantamento e uma questão tradutória que pas- sa pela possibilidade da intraduzibilidade de sua obra.
A origem indiana de um mito do Brasil colonial
Authors: Navarro Eduardo de Almeida
Published: June 2021

Este artigo relata a história do mito de São Tomé desde seu surgimento na Índia e como ele pôde existir no Brasil no período colonial, desempenhando um importante papel na assimilação pelos portugueses dos novos fatos culturais revelados pela colonização
Faces e contrafaces: alguns aspectos da Obra de Amós Oz
Authors: Waldman Berta
Published: June 2021

Este ensaio alinhava o cruzamento de aspectos políticos na obra literária de Amós Oz. Questões antes reprimidas pela geração de escritores vinculada à fundação do Estado de Israel vêm à tona na literatura de Oz. Meu intuito foi ressaltar o lugar de destaque que essa literatura dedica à presença e à voz do “outro.”
Indicações a respeito da divisão das ciências em IBN SINA (AVICENA)
Authors: Attie Filho Miguel
Published: June 2021

No interior da falsafa, o tema da classificação das ciências foi um dos pontos importantes que marcou a presença das teorias da filosofia e da ciência escritas em árabe na formação do pensamento medieval da Europa, a partir das traduções para o latim, notadamente no séc. XII d.C. O presente artigo apresenta a divisão das ciências de acordo com as informações contidas na Metafísica da AlShifa’ e na Epístola sobre as partes das ciências intelectuais de Ibn Sina (Avicena 980-1037 d.C.).
A tradição cristã e a valorização da origem judaica de figuras da poesia romântica brasileira
Authors: Jesus Daniel Santana de
Published: June 2021

Este trabalho tem por objetivo discutir o fenômeno da valorização da origem judaica de figuras da poesia romântica brasileira, mesmo em presença de elementos da tradição cristã. Em várias passagens deste trabalho, tal postura será, no entanto, sempre relativizada quando se notarem ambigüidades.
Abstract 212: Incidence of Depression and Anxiety in Patients With Durable Left Ventricular Assist Device
Authors: Cooper Stephanie G , Whyte Sharon , Hansell Cole , Horvath Katelyn , Mahr Claudius W , Mokadam Nahush A , Kirkpatrick James
Published: June 2021

Incidence of Depression and Anxiety in Patients with Durable Ventricular Assist Devices Background: There is a high incidence of depression in patients with heart failure and the presence of depression is associated with worse outcomes. There have been few reported data on depression in patients with left ventricular assist devices (LVADs).

Methods:
Patients with LVAD were seen by a palliative care practitioner embedded in the cardiology/CT surgery outpatient clinic at a large quaternary care hospital as part of routine post VAD management. The patients were screened for anxiety and depression as part of the palliative care clinical assessment, using previously validated PHQ-9 and GAD-7 tools. Their scores were entered into a QI database. Patients were considered to have scores concerning for depression if the total PHQ-9 score was greater than or equal to 10 (moderate depression) or if they met USPTF scoring criteria for major or other depressive disorders. Scores of greater than or equal to 10 on the GAD-7 were considered concerning for generalized anxiety disorder.

Results:
129 unique post LVAD patients were seen over 40 months, over a timeframe of 3 months to 5 years post implant. Of these, 110 (85%) were screened for depression using the PHQ-9 tool, usually at the first visit, or at a second follow up visit. 20 (18%) of those surveyed had met the above criteria for at least moderate depression, and 6(5%) had scores ≥ 15 consistent with at least moderate to severe depression. 83 were surveyed for anxiety using the GAD-7, and 8 (10%) had scores ≥ 10. Four patients had significant scores for both anxiety and depression. Of those patients who screened positive for significant depression, most (13/20, 65%) had a history of depression and were on antidepressants (13/20, 65%).

Conclusion:
The incidence of depression and/or anxiety in patients with LVAD, although higher than that of the general population (depression reported as 5-9%), appears to be on the low end of par with that reported in heart failure (depression incidence reported as 13-48% in the outpatient HF population). In our cohort, depression or anxiety were primarily observed in patients who already had a history of such. This finding is somewhat reassuring in that VAD therapy does not appear to induce these symptoms de novo. Nonetheless, patients with such a history are likely at risk for worsening symptoms with the significant stressor of undergoing VAD implant. Given the negative impact of depression on quality of life, this population should be carefully screened and supported both pre and post VAD implant.
Abstract 023: Angiotensin-(1-7) Reduces Doxorubicin-Induced Cardiac Fibrosis
Authors: Rahimi Omeed , Tallant E. Ann , Gallagher Patricia E
Published: June 2021

Doxorubicin (Dox) is a commonly used and effective chemotherapeutic agent for childhood leukemias and sarcomas. However, Dox administration often results in cumulative dose-dependent cardiotoxicity that manifests as cardiomyopathy with marked fibrosis that leads to reduced cardiovascular function and heart failure. Consequently, there is a need for adjunct therapies to reduce Dox-induced cardiotoxicity and enhance long-term quality-of-life in cancer patients, especially in pediatric patients. Angiotensin-(1-7) [Ang-(1-7)] is an endogenous peptide hormone of the renin-angiotensin system with cardioprotective properties; studies by us and others showed that Ang-(1-7) reduces cardiac fibrosis and improves cardiac function in various animal models. In this study, we investigated whether adjunct Ang-(1-7) attenuates cardiotoxicity resulting from an acute (6 week) exposure of juvenile Sprague-Dawley rats (male, n = 8-10) to Dox (22 mg/kg). Dox treatment reduced body mass, cardiac weight and cardiomyocyte size, while Ang-(1-7) co-administration had no effect on these changes. However, co-administration of Ang-(1-7) prevented Dox-mediated increases in cardiac fibrosis (interstitial fibrosis: 1.4 ± 0.1% to 2.5 ± 0.3%; perivascular fibrosis: 15.8 ± 1.4% to 23.2 ± 1.6%; p < 0.01) and coronary vessel hypertrophy (media-to-lumen ratio: 2.4 ± 0.2 to 3.3 ± 0.3; p < 0.05). Administration of Dox significantly increased E/E’ by 47%, a marker of diastolic dysfunction, and pulse wave velocity by 74%, as a measure of arterial stiffness, quantified using a Vevo 2100 small animal ultrasound system; co-administration of Ang-(1-7) prevented the Dox-induced increases in diastolic dysfunction and arterial stiffness. In contrast, Ang-(1-7) had no effect on the Dox-mediated reductions in ventricular diameter, parasternal wall thickness, stroke volume and cardiac output. The anti-fibrotic and anti-hypertrophic effects of Ang-(1-7) may account for the improvement in diastolic and arterial function. Collectively, these results suggest that adjuvant Ang-(1-7) may attenuate cardiac fibrosis and toxicity induced by Dox administration.
Abstract TP114: Histone Deacetylase Inhibitors Panobinostat and Entinostat for Motor Recovery After Ischemic Stroke in Mice
Authors: Al Shoyaib Abdullah , Alamri Faisal , Syeara Nausheen , Jayaraman Srinidhi , Karamyan Serob , Thiruma Arumugam V , Karamyan Vardan T
Published: June 2021

In this study, we investigated the potential of two histone deacetylase (HDAC) inhibitors, panobinostat and entinostat, to enhance recovery of motor function after ischemic stroke in CD-1 male mice. Panobinostat, which is a pan-HDAC inhibitor, is an FDA-approved drug for certain cancers, whereas entinostat is a class-I HDAC inhibitor and is widely expected to get approval for clinical use in near future. Stroke was induced by photothrombosis and the drugs were administered intraperitoneally every other day (panobinostat at 10 mg/kg or 30 mg/kg; entinostat at 5 mg/kg or 15 mg/kg) starting from day 5 to day 15 after stroke. The control group received only vehicle following the same regimen. In addition, all drug or vehicle-treated mice exercised for 2 hours (voluntary wheel running) starting from day 9 to day 41 after stroke. Additional control groups included sham-operated animals, and mice which had stroke but were not drug/vehicle-treated or allowed to run. Motor function of the mice was evaluated by blinded investigators using gridwalk and cylinder tests before and after stroke. Acetylation of histone 3 in the peri-infarct region of the brain samples was measured by immunoblotting. Our results indicate that lower dose of both panobinostat and entinostat marginally improved motor function in mice by day 42 after stroke, although it did not reach statistical significance. Notably, this improvement trend was lost with the higher dose of both drugs which also showed some toxicity. No statistical difference was observed in running distance of mice among experimental groups. Likewise, we did not observe statistically significant difference in stroke volumes among the experimental groups. Immunoblotting experiments indicated that both panobinostat and entinostat dose-dependently increased the level of acetylated histone in the cortical, peri-infarct region of drug-treated animals compared to the non-treated groups. In summary, our results indicate that both panobinostat and entinostat do not facilitate improvement of motor function after stroke at the tested doses. However, it is likely that lower doses of these drugs may enhance recovery of motor function after stroke.
Abstract WP477: Neuro-Cognitive Outcomes After Transitioning to Pit Crew Model for Out of Hospital Cardiac Arrest
Authors: Vindhyal Mohinder Reddy , Vindhyal Shravani , Nduna Paul , Duran Brent
Published: June 2021

Introduction:
Survival and neurological outcomes from the out of hospital cardiac arrest (OHCA) varies from one region to another depending on the different practices followed by the emergency personnel. Our study looked into neuro-cognitive outcomes post OHCA before and after adopting a pit crew model approach in one of the largest counties in Kansas.

Methods:
The data was collected by the emergency medical services (EMS) before transitioning (from 2010 - 2012) and after transitioning (from 2013-2016) to the pit crew approach. The patient demographics and resuscitation variables were similar and comparable including the emergency and fire department personnel. The primary outcomes were the average number of pauses >10 seconds and the cerebral performance post return of spontaneous circulation (ROSC)

Results:
The average number of CPR pause time > 10 seconds post pit crew model was 1 vs 5 (p=0.01). Cerebral performance post return of spontaneous circulation using pit crew approach with good cerebral performance was 56% vs 47% (p=0.2), moderate cerebral disability was 17% vs 23% (p=0.19), severe cerebral disability was 8% vs 11% (p=0.44) and in coma/vegetative state was 8% vs 16% (p=0.001).

Conclusion:
This focused model of high-quality CPR performance with the individualized assigned task has shown a declining trend in the rates of cerebral disability especially with moderate and severe cerebral performance including the patients in coma or vegetative state. More studies with better neuro-cognitive follow-up care after ROSC is needed to further establish the superiority of pit crew model approach.
基於概念域的殷墟甲骨文“其”字研究
Authors: 時 兵
Published: June 2021

殷墟甲骨文“其”字用於知、言、行三域，主要表情態。“其”在知域中表可能性，在正反對貞卜辭中構建矛盾等關係；在言域中表允許，其後在西周金文中進一步虛化表希冀語氣；在行域中表將來時間。這些用法在認知上存在著內在的聯繫。“其”的情態功能與遠指功能之間也有關聯，並延伸至消極情感的表達，這正是司禮義“其”字規則形成的基礎。另外，甲骨文“其”是助詞，具有依附性，一般後附綴於否定詞；與此同時，“其”字前移在句法上已初顯端倪。
From Qièyùn to Guǎngyùn
Authors: Jī Yuè
Published: June 2021

The Qièyùn Series rime books (Qièyùn-xì yùnshū 切韻系韻書), not only the two complete editions, the Kānmiù Bǔquē Qièyùn 刊謬補缺切韻 (also known as Wángyùn 王韻) and Guǎngyùn 廣韻, but also many other fragments, are of great importance in studying Middle Chinese phonology. This paper aims to comprehensively introduce the materials of the Qièyùn Series rime books, from the original Qièyùn 切韻 to later revised editions until the Five Dynasties (Wǔdài 五代), including essential research on them. And finally, by using specific examples, this article summarized the development from the Qièyùn 切韻 to the Guǎngyùn 廣韻 through the four-century-long history of revision and extension.
台灣閩南語「煞」的左緣化
Authors: 連 金發
Published: June 2021

本文探索現在閩南語中「煞」的句法語義表現。「煞」為多功能的語詞，可充當動詞、動相補語、連接性副詞及助詞。「煞」的語義轉變都與它的句法結構位置息息相關。從「煞」和其他功能範疇的相對語序，可以驗證句法位置與語義詮釋的互動關係。從功能範疇層級觀點來看，「煞」充當動詞，因在動詞詞組中，所以可以預測出現於否定轄域中；而表言談層次或發話者取向的「煞」佔據句標階層中語勢之上的言談行為層，因此必然會出現於否定詞之前。此外，句末助詞所表現的主觀估量語義也反映出其位居言談行為層的結構特性。
Schwenckia aurantiaca (Solanaceae), a new species from calcareous outcrops of northern Minas Gerais, Brazil
Authors: PAUCAR JENNY OLGA ARREA , STEHMANN JOÃO RENATO
Published: June 2021

A new species of Schwenckia (Solanaceae) from calcareous outcrops of the Serra Azul Biological Reserve in northern Minas Gerais, Brazil, is described and illustrated. Schwenckia aurantiaca is an annual plant characterized by a cylindrical corolla tube with five orange, linear appendages, an androecium with two stamens and three, unequal pilose staminodes, and a calyx that tears to the base in fruit. We discuss the morphological characters, habitat, and conservation status of the species, which is assessed as Critically Endangered.
A new Dryadella Luer (Orchidaceae: Pleurothallidinae) from the South Atlantic Rainforest
Authors: IMIG DANIELA CRISTINA , MANCINELLI WERNER SIEBJE , SMIDT ERIC DE CARMAGO
Published: June 2021

Dryadella catharinensis, a new orchid species found in the north-northeast part of the Santa Catarina state, in southern Brazil, is described here. The tiny new species was found in the dense ombrophilous submontane forest (Floresta Ombrófila Densa Submontana) in the Atlantic Rainforest. It is similar to Dryadella susanae, which is endemic of the Espírito Santo state and differs in the larger vegetative size, the narrow and suberect leaf, yellow flowers, the sepals with slightly denticulate margins, the petals with an obtuse apex and the cuneate lip with denticulated margins and a annular callus in the median portion of the claw. It is the fifteenth Dryadella species restricted to the Atlantic Rainforest (~25% of the genus), evidencing the importance of the conservation of this biome—of which only 11% remains—for the genus. Due to the rarity and low density of this species in the field, allied to the degradation of the habitat, we suggest a conservation status of Endangered. Further fieldwork is needed to locate additional populations and study the biological aspects for their conservation.
Compsodactylus Fuhrmann, 2012 (Coleoptera: Scarabaeidae: Melolonthinae): distributional notes and a new species
Authors: FUHRMANN JUARES , SMITH ANDREW B.T.
Published: June 2021

A new species of Compsodactylus Fuhrmann, 2012 (Coleoptera: Scarabaeidae: Melolonthinae: Macrodactylini) is described from Peru. New provincial records for Compsodactylus argentinus (Moser, 1919) are detailed for Argentina: Córdoba and Misiones. A revised key to Compsodactylus species is presented.
Revision of Chinese crickets of the tribe Modicogryllini Otte & Alexander, 1983 with notes on relevant taxa (Orthoptera: Gryllidae; Gryllinae)
Authors: MA LIBIN , ZHENG YANNA , QIAO MIN
Published: June 2021

The article revised most species of genera of Modicogryllus Chopard, 1961, Gryllodinus Bolívar, 1927, Eumodicogryllus Gorochov, 1986, Svercacheta Gorochov, 1993 and Turanogryllus Tarbinsky, 1940 and proposed a new species, Gryllodinus jijilacus sp. nov., four synonyms, Mirigryllus He, 2020 syn. nov., Gryllus bordigalensis (=Eumodicogryllus bordigalensis) Latreille, 1804 syn. nov., Gryllus chivensis (=Eumodicogryllus chivensis) Tarbinsky, 1930 syn. nov. and Gryllopsis aelleni (=Turanogryllus aelleni) Chopard, 1954 syn. nov., seven new combinations, Modicogryllus (Modicogryllus) nigrus (He, 2020) comb. nov., Mitius vaturu (Otte & Cowper, 2007) comb. nov., Loxoblemmus abrictos (Otte, 2007) comb. nov., Modicogryllus (Promodicogryllus) nigericus (Chopard, 1961) comb. nov., Eumodicogryllus chinensis (Weber, 1801) comb. nov., Eumodicogryllus vicinus (Chopard, 1968) comb. nov. and Svercacheta semiobscurus (Chopard, 1961) comb. nov., and re-established a species, Modicogryllus (Modicogryllus) latefasciatus (Chopard, 1933), as well as redescribed species of Modicogryllus (Promodicogryllus) consobrinus (Saussure, 1877), Svercacheta siamensis (Chopard, 1961) and Turanogryllus lateralis (Fieber, 1853).
One new species of the genus Etielloides Shibuya, 1928 from China (Lepidoptera, Pyralidae, Phycitinae)
Authors: YANG LINLIN , LIU HONGXIA , REN YINGDANG
Published: June 2021

One new species, Etielloides luniformis sp. nov. is described based on specimens collected from Mt. Leigong, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou of China. Adults, venation, head and genitalia structures of both sexes are described and illustrated, along with a key to all the known species of the genus Etielloides. DNA barcodes of the new species and its related species are provided for species delimitation.
Mechanism of Ampelopsin Inhibiting Proliferation, Remove and Incursion of Colorectal Cancer Through Regulating the Expression of LncRNA ZFPM2-AS1/miR-515-5p
Authors: Yuan Sheng , Yu Dazhong
Published: June 2021

The incidence rate, recurrence and metastasis rate and mortality of colorectal cancer (CRC) are high. Therefore, clinical has been looking for better treatment. Ampelopsin (AMP) has obvious inhibitory effect on some tumors. However, there is no report on the effect and mechanism of
AMP on rectal cancer. To investigate the effect and mechanism of AMP on the proliferation, migration and invasion of colorectal cancer cells, at first, different concentrations of Ampelopsis japonica group (10μM, 25 μM, 50 μM), control group (without AMP), pcDNA
group, pcDNA-ZFPM2-AS1 group, si-NC group, si-ZFPM2-AS1 group, miR-NC group, miR-515-5p group, AMP+pcDNA group, AMP + pcDNA-ZFPM2-AS1 group were set up. Then the expression levels of miR-515-5p and ZFPM2-AS1 were detected by QRT-PCR, protein expression was detected by Western blot, cell proliferation
inhibition rate was detected by MTT method, cell invasion and migration were detected by Transwell and fluorescence activity was detected by double luciferase reporter gene assay. The results show that compared with the control group, the proliferation inhibition rate of SW480 cells in different
concentrations of AMP increased and the number of migration and invasion decreased significantly. Moreover, the expression levels of CyclinD1, MMP-2 and MMP-9 were significantly lower than those in the control group, while the expression of p21 was significantly increased. The expression level
of miR-515-5pin SW480 cells treated with AMP was significantly increased, while the expression level of ZFPM2-AS1 was significantly decreased. Inhibition of ZFPM2-AS1 expression or miR-515-5p overexpression could inhibit the proliferation, migration and invasion of SW480 cells and then ZFPM2-AS1
overexpression reversed the inhibitory effect of AMP on the proliferation, migration and invasion of SW480 cells. Therefore, AMP affects the proliferation, migration and invasion of colorectal cancer cells by regulating the expression of lncRNA ZFPM2-AS1/miR-515-5p, which provides a new target
and new idea for the prevention and treatment of colorectal cancer.
Molecular Mechanism of Neurotrophic Factor-Activated Long Non-Coding RNA Plasmacytoma Variant Translocation 1 Promoting Mesenchymal Stem Cell Migration and Repair of Fractures
Authors: Yang Linyu , Dai Haoping , Yang Jian , Yang Han , Yang Daoyin , Kang Jianping
Published: June 2021

It has been reported that neurotrophic factor (NF) promotes bone marrow mesenchymal stem cells (MSCs) migration to repair fractures. However, whether and how lncRNA PVT1 regulates differentiation induced by neurotrophic factors to promote MSC migration to repair fractures has not been
explored. To explore the molecular mechanism of neurotrophic factor activating lncRNA PVT1 to promote MSC migration and repair fractures. Differential expression of neurotrophic factors stimulated by MSCs was analyzed based on microarray lncRNA and lncRNAs was further verified by qRT-PCR.
The conditions of promoting MSC migration and osteogenic differentiation were identified by trans-fection of lncRNA PVT1 overexpressed plasmids and inhibitor and the targets of its regulation were confirmed by target gene prediction tools. In this study lncRNA array and qRT-PCR showed that
lncRNA PVT1 was significantly down-regulated during neurotrophic factor-induced MSCs differentiation. Transfection of lncRNA PVT1 overexpression plasmid significantly inhibited the expression of osteogenic markers alkaline phosphatase (ALP) and osteopontin (OPN) in MSCs, while transfection
of lncRNA PVT1 inhibitor promoted the expression of alkaline phosphatase (ALP) and osteopontin (OPN). lncRNA PVT1 is a negative regulator of MSCs differentiation induced by neurotrophic factors. The distal deletion homologous box 5(DLX5) was identified as the target of lncRNA PVT1 and the
relationship between lncRNA PVT1 inhibiting the expression of DLX5 and the osteogenic differentiation of MSCs was verified in MSCs. lncRNA PVT1 negatively regulates the migration and differentiation of MSCs induced by neurotrophic factors by targeting DLX5, providing the foundation for bone
repair.
Member Domain 3 (LRIG3) Activates Hypoxia-Inducible Factor-1 α/Vascular Endothelial Growth Factor (HIF-1α/VEGF) Pathway to Inhibit the Growth of Bone Marrow Mesenchymal Stem Cells in Glioma
Authors: Zhou Haiyan , Cao Jing , Yang Fan , Fan Duojiao , Li Hengzhou , Fan Tao , Sun Peng
Published: June 2021

Member domain 3 (LRIG3) of the LRIG gene family is down-regulated in several cancers. However, its role in bone marrow mesenchymal stem cells (BMSCs) in gliomas and the related mechanisms is unknown. The qRT-PCR assessed LRIG3 mRNA level. Rat BMSCs were randomly assigned into glioma
group (BMSCs cultured in glioma microenvironment); LRIG3 overexpression group; and si-LRIG3 inhibitor group followed by analysis of LRIG3 expression, cell proliferation, PCNA and Ki-67 apoptosis, TNF-α; and HIF-1α/VEGF mRNA level. LRIG3 mRNA expression was decreased
in gliomas patients (P < 0.05). BMSCs cultured in glioma microenvironment showed decreased LRIG3, increased cell proliferation, decreased PCNA, Ki-67 and TNF-α secretion as well as elevated HIF-1α and VEGF level (P < 0.05). Transfection of LRIG3
siRNA further promoted the above changes. Conversely, LRIG3 plasmid transfection significantly promoted its expression in glioma BMSCs (P < 0.05), inhibited cell proliferation, promoted PCNA, Ki-67, and TNF-α secretion, and increased HIF-1α and VEGF level
(P < 0.05). LRIG3 in rat BMSCs cultured in the glioma microenvironment is decreased. Down-regulation of LRIG3 inhibits TNF-α secretion by activating HIF-1α/VEGF pathway regulating BMSCs proliferation and apoptosis.
miR-340 Restrains the Growth of Lung Cancer Cells Through Mitogen-Activated Protein Kinase (MAPK) Signaling
Authors: Zheng Wenhong , Xie Wenrui , Fu Lijuan , Fu Zhengqi
Published: June 2021

The lung cancer was most deadly tumor in the world and the suvival rate needs to be improved clinically and urgently. The abnormal miR-340 expression is found in several solid tumors. Our study was aimed to explore miR-340’s role in lung cancer. 14 cases of patients with lung
cancer was selected to measure miR-340 level by RT-PCR and analyze its correlation with clinical characteristics. The relation between the miR-340 and DICER1 was detected by dual luciferase assay and cell proliferation was measured by MTT assay along with analysis of cell migration and invasive
by Scratch-Wound experiment. The miR-340 in lung cancer cells was reduced significantly and DICER1 was predicted to be a potential target of miR-340. DICER1 level was found to be negatively related with miR-340 level. The DICER1 as the direct target gene of miR-340 was conducive to improve
miR-340 function through overexpression and knock-out experiment further. Abnormal miR-340 level affected lung cancer cell proliferation and migration as well as MAPK signaling. miR-340 could affect the biological morphology and transformation of physiological function of lung cancer cells
mainly through restraining the expression of apoptosis and prompting the cellular proliferation, indicating that it might be a novel target to improve the treatment of lung cancer.
Expression and Clinical Significance of Long Non-Coding RNA RP4-669H2.1 in Glioblastoma
Authors: Sun Xinhu , Zhou Jingyu , Wu Xijuan , Yu Yongpeng , Zhan Xia , Xue Shuo , Zheng Yali , Ju Weiping
Published: June 2021

Neuroglioma is the most common malignant tumor in the central nervous system and still has a poor prognosis. Here, we investigated the prognostic value of long non-coding RNAs(lncRNAs) in glioblastoma. We first analyzed the lncRNA expression profiles of glioblastoma (GBM) in The Cancer
Genome Atlas database and selected the most differential survival genes (lncRNA RP4-669H2.1) for further validation. We then performed qRT-PCR using samples of 88 glioblastoma patients treated in our department between January 2011 and December 2017 that were retrospectively selected to validate
the prognostic value of RP4-669H2.1expression in glioblastoma. Using a Cox multivariate analysis, we explored the prognostic value of RP4-669H2.1 and analyzed whether it was an independent prognostic factor. This analysis confirmed that the RP4-669H2.1 expression was significantly associated
with glioblastoma-associated mortality in this patient cohort (P =1.80E–05) in TCGA database. In fact, the overall survival (OS) of the RP4-669H2.1 high-expression group (78 cases) was lower than that of the low-expression group (49 cases) (P = 4.6E–06) in TCGA database.
Moreover, the TNM stage of the RP4-669H2.1 high-expression group was higher than that of the RP4-669H2.1 low-expression group (P = 0.001). A multivariate analysis further showed that a higher TNM stage (OR = 2.167, 95% CI: 1.349–3.479) and a higher RP4-669H2.1 expression (OR =
2.933, 95% CI: 1.122–7.663) were independent risk factors for the OS of glioblastoma patients. Finally, we predicted the target genes of RP4-669H2.1 using a Multi Experiment Matrix and annotated their biological functions. We observed that the target genes of RP4-669H2.1 were mainly
enriched in biological functions related to DNA-binding transcription factor activity. Among these, we selected SMAD6 because the expression of RP4-669H2.1 was positively correlated with that of SMAD6 in glioblastoma. Overall, we conclude that the upregulation of RP4-669H2.1 is an independent
poor prognosis factor for glioblastoma and that it can regulate the DNA-binding activity of transcription factors.