bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of different final irrigation solutions on push-out bond strength of root canal filling material
Authors: Rahmatillah R. , Erlita Isyana , Maglenda Buyung
Published: November 2020

Background: The adhesion of root canal filling material to dentin is one of the crucial factors in determining the success of endodontic treatment. However, the smear layer that forms during instrumentation serves as an interface that impedes the bonding mechanism of the filling material. A proper irrigation solution is required to remove the smear layer and provide a dentin surface that supports the bonding mechanism of the filling material in establishing good adhesion. Purpose: This study aims to evaluate and compare the bond strength of filling material with different final irrigation solutions. Methods: Mandibular premolars were prepared by a crown down, pressure-less technique and divided into three final irrigation groups (2.5% NaOCl, 17% EDTA and 20% citric acid). The root canal of each tooth was obturated using epoxy sealer and gutta-percha. A two-millimetre-thick section of the apical third portion of each group was arranged for the push-out assessment using a universal testing machine in an apical to coronal direction at 1 mm/min crosshead speed. Results: A one-way ANOVA test indicated the difference in push-out bond strength among the groups (p<0.05). A post hoc Bonferroni test presented a statistically significant difference in the bond-strength value between the 2.5% NaOCl group compared with the 20% CA group (p<0.05). Conclusion: The push-out bond strength of root canal filling material is increased by applying a chelating agent as the final irrigation solution where 20% of CA presents the highest push-out bond strength.
Orthodontic camouflage treatment using a passive self-ligating system in skeletal Class III malocclusion
Authors: Monika Fransiska , Widayati Retno
Published: November 2020

Background: The treatment options for adults with skeletal Class III malocclusion can be dentoalveolar compensation, also known as orthodontic camouflage, or orthognathic surgery. Camouflage treatment can be carried out with teeth extractions, distalisation of the mandibular dentition, and use of Class III intermaxillary elastics. However, intermaxillary elastics as anchorage has its own risk–benefit. Purpose: To explain that camouflage treatment with teeth extractions can be performed in a mild to moderate skeletal Class III malocclusion using intermaxillary anchorage with elastics, while minimising the deleterious effects and achieving a satisfactory treatment outcome. Case: Our patient was a 25-year-old female who had a skeletal Class III pattern, with normal maxilla and a protruded mandible. She had a straight facial profile with a Class III canine and molar relationship on her right and left sides. Anterior crossbite was also present with crowding on both the maxilla and the mandible. Case Management: The treatment plan was carried out with dentoalveolar compensation by extracting teeth. Extraction of the lower first premolars was conducted to eliminate the crowding and correct the anterior crossbite. The mandibular incisors were retroclined and the maxillary incisors were proclined with dentoalveolar compensation. Passive self-ligating system was used with standard torque prescription, intermaxillary anchorage, and no additional appliances for anchorage control. Class I canine and incisor relationship were both achieved at the end of the treatment, while maintaining the Class III molar relationship. Conclusion: Orthodontic camouflage treatment in an adult patient using a passive self-ligating system and intermaxillary anchorage can improve facial profile and improve dental occlusion.
Acceleration of post-tooth extraction socket healing after continuous aerobic and anaerobic physical exercise in Wistar rats (Rattus norvegicus)
Authors: Oki Aqsa Sjuhada , Alviansyah Moch Febi , Khoswanto Christian , Rahayu Retno Pudji , Luthfi Muhammad
Published: November 2020

Background: Physical exercise has been proven to accelerate wound healing. Physical training itself consists of aerobic (continuous training) and anaerobic (interval training) exercise. The effectiveness of continuous physical exercise on post-tooth extraction wound healing is the focus of this study. Purpose: This study aims to investigate the differences in post-tooth extraction wound healing in Wistar rats (Rattus norvegicus) after aerobic and anaerobic exercise based on the number of fibroblasts and neovascularisation. Methods: Wistar rats were divided into three groups: the control group (K1); K2 undertook continuous aerobic exercise, swimming at 50% maximum swimming capacity (MSC) with an additional 3% bodyweight load; K3 undertook anaerobic continuous exercise, swimming at 65% MSC with a 6% load. The rats swam three times per week for six weeks. The number of fibroblasts and neovascularisation were examined three days after tooth extraction. Data was analysed using the one-way analysis of variance (ANOVA) and Least Significant Difference (LSD) tests (p<0.05). Results: There was a significant difference in the number of fibroblasts between the K2 and K3 groups. There was no significant difference between K2 and K3 in the amount of neovascularisation. Conclusion: There were differences in the number of fibroblasts but not neovascularisation after tooth extraction in Wistar rats given aerobic and anaerobic continuous training.
Keterkaitan Faktor-Faktor Organisasional, Individual, Konflik Peran, Perilaku Etis Dan Kepuasan Kerja Akuntan Manajemen
Authors: Husein Muhammad Fakhri
Published: November 2020

This research develops a model for the linkage of organizational factors (role model, understanding code of ethics, and organizational commitment), individual factor (moral principle) to role conflict, ethical behavior, and their consequences to job satisfaction of management accountants in Indonesia. Using purposive sampling, this research is supported by 119 respondents. The response rate is 23,8%.To get a comprehensive view on antecedents of ethical behavior and role conflicts and their consequences to job satisfaction, this research is supported by management accountant respondents. Measurement of model is performed in analysis in Structural Equation Modeling by Analysis of Moment Structure (AMOS). Some indicators of goodness of fit model are still unsatisfactory, but this research confirms some hypotheses of the previous researches. Understanding Code of Ethics, organizational commitment and role model influence significantly ethical behavior of management accountants. Meanwhile, moral principle does not influence significantly ethical behavior of management accountants.Role conflict is not influenced significantly by understanding code of ethics and moral principle, but it is influenced significantly by organizational commitment and role model. Management Accountant job satisfaction is influenced significantly by ethical behavior but role conflict doesn’t influence significantly management accountant job satisfaction.
Ethical Work Climate Untuk Menciptakan Moral Awareness Karyawan Pada Koperasi Bank Perkreditan Rakyat Tribakti Nganjuk
Authors: Sulasmi Siti , Widhianto IGM Dwi
Published: November 2020

This study would examined empirically which one of these ethical criteria, namely self-interest, company, interest, efficiency, friendship, team play, social responsibility, personal morality, rules and procedures, and the law or professional code variables as the criteria’s to create Ethical Work Climate influenced significantly upon moral awareness of the 170 marketing division employee of TRIBAKTI KBPR (Koperasi Bank Perkreditan Rakyat – People Credit Cooperative Bank) in Nganjuk East Java. The result showed that self-interest, company interest, efficiency, friendship, team play, social responsibility, personal morality, rules and procedures, as well as professional code variables simultaneously create significantly employees moral awareness. Individually, rules and procedure, friendship, team play, personal morality, as well as the law or professional code variables were the ethical criteria that significantly arouse moral awareness. While self-interest criteria variable was to some extent significant, it were contrary to moral awareness development of KBPR’s employees. The other three Ethical Work Climate variables, namely company interest, efficiency and social responsibility showed no significant effect.
Pengaruh Mekanisme Corporate Governance Terhadap Kinerja Keuangan Badan Usaha
Authors: Puspitasari Filia , Ernawati Endang
Published: November 2020

Nowdays, most researches in corporate governance field are conducted by researchers based on rising of many firms to become public corporation. According to this situation, they have to separate their functions on ownership and control of the firm. As result, it will arise agency conflict between owners and managers. The corporation enable solve the problem by apply the corporate governance mechanism optimally. This research is a replication research is conducted by Sanda et al (2005). It’s explained the specific study about the impact of corporate governance mechanism include managerial ownership, board size, outside directors, ownership concentration, and debt toward financial performance that measured by ROA, ROE, PER, and TOBINS’Q. The samples of this research are all corporations which listed at Bursa Efek Indonesia (BEI) by all sectors that delivered financial statement on time by regulation. The period of time in this research determined on 2005-2007. The model is extended by quadratic of managerial ownership, quadratic of board size, quadratic of ownership concentration, CEO foreign and firm size as control variables, and sectoral dummy. The result of this research explained that corporate governance mechanism simultaneously influence to ROA and ROE significantly. On partially, ROA is influenced by CEO foreign, debt, and firm size significantly. And ROE is inluenced by CEO foreign, firm size, and sector of basic industry significantly.
Effisiensi Produksi Industri Skala Kecil Batik Semarang: Pendekatan Fungsi Produksi Frontier Stokastik
Authors: Ngatindriatun Ngatindriatun , Ikasari Hertiana
Published: November 2020

Batik is known since 17th century. In 2009, UNESCO took batik as the world heritage. Likewise, Batik Semarang. Batik Semarang is unpopular than other batik’s products on Central Java. Their productivity is on small scale and only for environment surroundings. The small productivity causes the high price on their product selling. The aims of this research are to estimate the function of production and technical efficiency of batik Semarang. Sample is 67 owners of small scale batik Semarang industry. Analysis instrument is Stochastic Frontier Production Function. The measuring of production efficiency are material, support material, labor force, instruments, kerosene, firewood, and large of trade location. The result shows that free variable is found significant and have an appropriate signal. Other result shows that technical efficiency of batik Semarang industry is 88, 9%
Efektivitas Hedging Kontrak Futures Komoditi Emas Dengan OLEIN
Authors: Ismiyanti Fitri , Sasmita Hendra Ima
Published: November 2020

This research is for comparing hedging effectiveness in gold and olein commodity. Using Ordinary Least Square (OLS) model to determine the hedge ratio, it’s found that olein hedge ratio is bigger than gold hedge ratio. The value of olein hedge ratio is bigger than gold hedge ratio indicate that to eliminate loss in olein spot market is needed a lot of futures contract as compared to eliminate loss in gold spot market. However, independent t-test to return hedged variance both commodity show there is no different variance. This mean the return hedged variance of gold commodity has the same value with olein return hedged variance. So, handling the systematic risk of olein hedger have the same as of gold hedger handling. With the result that, if doing hedging strategy and there is no same instrument to be hedged in futures market, so hedger may considering to use cross hedging strategy, but previously determined first the optimum hedge ratio, because the optimum hedge ratio can reduce the variance return caused by market risk (systematic risk).
Analisis Kecacatan Produk Fillet Skin On Red Mullet Dengan The Basic Seven Tools Of Quality Dan Usulan Perbaikannya Menggunakan Metode Fmea (Failure Modes And Effect Analysis) Pada PT. Holi Mina Jaya
Authors: Aryanto Andi Trias , Auliandri Tuwanku Aria
Published: November 2020

Increasingly fierce competition make quality becomes a more value in the eyes of consumers. Keeping quality of being a need for companies to be able to stay in business. PT. Holi Mina Jaya is an Indonesian company that is engaged in marine fish processing. One of the flagship products offered are Fillet Skin On Red Mullet. The purpose of this study was to identify factors disability that occurs in the product Red Mullet Fillet Skin On analysis of the seven basic tools of quality and propose improvements to the failure modes and effects analysis (FMEA). The study focused on the stages of production that have a direct impact on the finished products includes receiving, filleting, and washing. This study uses five of the seven basic quality tools, which flow charts, check sheets, histograms, cause and effect diagram and Pareto charts to identify defects. For quality improvement proposals using FMEA method by finding the value of the RPN (Risk Priority Number), have described the RPN value calculation by multiplying the value of Severity, Occurrence and Detection. Highest cause of any kind of disability, like any form of meat are less scrupulous employees, and skilled with the value of RPN 120, not fresh fish product defects are less rigorous sorting process HR RPN value by 54, and the last meat is not clean of thorns is less scrupulous employees with RPN at 36.
Analisa Pengaruh Penerapan Manajemen Kualitas Dengan Mbnqa Kriteria Terhadap Kinerja Bisnis Pada Rumah Sakit Islam Jemursari Surabaya
Authors: Sutikno Arief Sabda Pietra Mukti , Wurjaningrum Febriana
Published: November 2020

Today, high population growth coupled with the needs of the product or service quality healthcare. One practice in improving quality is through the implementation of Total Quality Management or TQM. One of the efforts in the implementation of TQM can be done with criteria MBNQA consisting of leadership, strategic planning, customer focus, pekuruan, analysis, and knowledge management, workforce focus, process management, and business results. RSI Jemursari Surabaya as one of the hospitals of foundation hospitals islam Islam Surabaya (Yarsis) has implemented MBNQA in its business operations. This study examines the relationship between TQM implementation through MBNQA on business performance criteria of Islamic Hospital Jemursari. Data were analyzed using path analysis using Partial Least Square method with the help of software SmartPLS. From the research results obtained by the t-statistic for the criteria of customer focus 6.153 ; management process by 5.451; 5.168 leadership; strategic planning 4.314; and 2,628 business results. While the measurement, analysis, and knowledge management did not prove significant influence and adversely affect the value of the path coefficient of -0.014 with 0.288 t and the focus of labor is not proved significant with path coefficient value of 0,020 with 0,349 t.
Bentuk Loyalitas Donatur Pada Organisasi Filantropi
Authors: Handriana Tanti
Published: November 2020

Baik organisasi laba maupun nonlaba, keduanya membutuhkan relasi yang baik dengan pelanggan (donatur). Relasi yang terjalin di antara donatur dan organisasi filantropi merupakan kunci untuk meraih keberhasilan dan kelanggengan organisasi. Tujuan dari artikel ini adalah untuk menggali dan menganalisis informasi tentang bentuk-bentuk loyalitas pelanggan/donatur pada organisasi filantropi. Riset ini menggunakan metode penelitian kualitatif, dengan menggunakan teknik pengumpulan data berupa wawancara mendalam (indepth interview) pada para donatur organisasi filantropi. Sebagai pembanding (tri angulasi), maka dilakukan wawancara mendalam juga dengan pakar manajemen pemasaran serta organisasi filantropi. Hasil riset menunjukkan bahwa donatur yang memiliki komitmen relasional yang tinggi, kepercayaan yang besar pada organisasi, dan rasa terima kasih pada organisasi filantropi cenderung memiliki perilaku loyal pada organisasi filantropi di mana mereka selama ini mendonasikan uangnya. Adapun bentuk-bentuk loyalitas yang mereka lakukan antara lain adalah berupa kemauan untuk terus memberikan sumbangan di organisasi filantropi, apabila mendapat rezeki yang lebih banyak maka jumlah donasi yang mereka berikan juga akan ditingkatkan, tidak akan beralih ke organisasi lainnya, rela/berkenan untuk memberikan sumbangan tenaga dan fikiran mereka apabila organisasi membutuhkannya, serta tidak sungkan-sungkan untuk memberikan masukan demi kebaikan dan masa depan organisasi tersebut. Dengan demikian, hasil riset ini mendukung konsep relationship marketing dan konsep loyalitas di organisasi non laba.
Engajamento no trabalho no setor supermercadista
Authors: Dutra da Silva Marilia Amarante , Obregon Sandra Leonara , Dias Lopes Luis Felipe , Da Cruz Ceretta Franciane Cougo , Pauleski Della Justina Dienifer
Published: November 2020

A presente pesquisa tem como objetivo analisar a percepção dos colaboradores do setor supermercadista em relação ao engajamento no trabalho. Para tal, realizou-se uma análise descritiva, de abordagem quantitativa por meio de Survey, na qual obteve-se uma amostra de 131 respondentes de seis supermercados situados na cidade de Tupanciretã – RS, utilizando-se a Escala de Engajamento no Trabalho (EEGT). Deste modo, os resultados indicam que a amostra apresenta altas médias de engajamento no trabalho, tanto para o aspecto vigor e dedicação, demonstrando que estão envolvidos e que o trabalho é visto como algo prazeroso, beneficiando o setor supermercadista da cidade pesquisada.
O EMPREENDEDORISMO NA TERCEIRA IDADE: UMA ALTERNATIVA SUSTENTÁVEL À CRISE DA PREVIDÊNCIA SOCIAL?
Authors: Freire Denilson Aparecida Leite , Muritiba Patricia Morilha
Published: November 2020

O objetivo desse artigo foi traçar um perfil do empreendedorismo brasileiro na Terceira Idade através do uso da técnica da Análise de Conteúdo dos relatórios do GEM (Global Entrepreneurship Monitor), dos Anuários Estatísticos Previdenciários e dos censos demográficos do IBGE dos anos de 2002 a 2010. Além disso, fez-se uma análise com os atuais dados da Previdência Social buscando estabelecer uma reflexão dos impactos desse empreendedorismo na economia nacional. Os dados revelaram que o Brasil investe pouco nesse tipo de empreendedorismo, estando em 40º lugar entre os países da América Latina. Demonstrou, ainda, que a aposentadoria é um dos obstáculos ao empreendedorismo, contudo não o mais importante. Torna-se necessária a elaboração de políticas públicas que subsidiem esse empreendedorismo, podendo se tornar uma das alternativas à crise da Previdência Social e à questão do endividamento dos idosos pelos empréstimos consignados. Sugere-se a inclusão do incentivo ao Empreendedorismo no Estatuto do Idoso.Essa nova lógica alteraria o paradigma de que o envelhecimento do país traria graves consequências negativas à economia, transformando esse envelhecimento em uma fonte de oportunidades.
Níveis de resiliência em adultos da geração Y de uma Instituição de Ensino Superior.
Authors: Roncon Aleksander , Beltrame Indiara , Campos Welington Carlos , Cangussu Ewerton Taveira , Mazzafera Bernadete Lema
Published: November 2020

Este estudo objetiva verificar os níveis de resiliência em adultos da geração Y de uma Instituição de Ensino Superior. Para tanto se desenvolveu uma pesquisa quantitativa, descritiva e transversal, por meio de levantamento de dados primários. A técnica utilizada foi survey, com aplicação do questionário validado por Barbosa (2006) que deu origem ao Questionário do Índice de Resiliência. Analisados os resultados considera-se que os respondentes se localizam entre a condição "Boa" do Padrão de Controle de Passividade e a condição "Moderada" do Padrão de Controle de Intolerância. Assim, clarifica-se a necessidade de melhorias e atualizações quanto ao comportamento resiliente.
Refletindo sobre os vínculos com a carreira dos militantes do MST: Entrincheiramento em análise.
Authors: Freire Denilson Aparecido Leite , Da Silva Leila Vaz , Muritiba Patricia Morilha , Santos Francisca Regilma de Santana
Published: November 2020

Este estudo analisou o entrincheiramento na carreira dos trabalhadores queatuam no Movimento Sem Terra (MST), através de um levantamento quantitativo com99 participantes do movimento. O entrincheiramento é um construto que engloba apercepção de falta de alternativas na carreira, custos emocionais e investimento nacarreira. Foram utilizadas escalas validadas, com um KMO de 0.741. Os resultadosmostraram níveis de entrincheiramento maiores entre: assalariados, com relação aosvoluntários; mulheres, com relação aos homens; e público das regiões Sul e Sudestedevido à questões históricas ligadas à Terra.
O regime de dedicação exclusiva e a gestão do tempo: estudo de caso com docentes universitários.
Authors: Quevedo Leonardo de Brito , Fleck Carolina Freddo , Do Carmo Karen Luciana Ferreira
Published: November 2020

Esta pesquisa propôs investigar o comportamento dos docentes atuantes sob regime dededicação exclusiva na UNIPAMPA, frente à gestão do tempo de trabalho e tempo livre. Oestudo teve caráter exploratório e descritivo, pois procurou compreender o comportamento deum grupo particular, configurando-se, portanto, como um estudo de caso. Escolheu-se comotécnica de coleta de dados a entrevista semiestruturada. Doze docentes foram entrevistados.Conclui-se que todos os docentes mantêm uma gestão do tempo de trabalho e do tempo livre,evidenciando que a atividade docente interfere na vida pessoal dos mesmos, principalmentena quantidade de tarefas do trabalho levadas para casa.
Editorial
Authors: Trevisan Leonardo , Dutra Joel Souza , Veloso Elza
Published: November 2020

A lógica do desafio sempre foi tratada como uma espécie de “motor“ nas expectativasde carreira. Indivíduos e organizações assimilaram de formas diferentes – às vezes complementares – todo o potencial desta “lógica”. A rigor, as dinâmicas mais recentes deevolução profissional, seja na carreira formal, organizacional, como nos “novos formatos”,parecem ter acolhido, como maior ênfase, a lógica do desafio.Porém, compreender o que são os “novos desafios” nas carreiras demanda algo mais doque apenas encontrar soluções criativas de conhecidos problemas corporativos.
Assédio moral no trabalho em universidade sob a perspectiva dos observadores da violência.
Authors: Nunes Thiago Soares , Tolfo Suzana Da Rosa , Nunes Letícia Soares
Published: November 2020

O assédio moral no trabalho é uma violência que pode acarretar em danos à integridadefísica e psíquica da vítima, sua vida pessoal e o desempenho no trabalho. Além da vítima,observadores da violência, podem sofrer as consequências na medida em que visualizamas agressões. Portanto, verifica-se a relevância científica de identificar a ocorrência deassédio e seus desdobramentos sob a percepção de observadores da violência. A pesquisafoi classificada como descritiva, quali-quanti e estudo de caso. Evidenciou-se que 52,2% dospesquisados têm conhecimento de casos de assédio no setor e/ou na instituição em queestão vinculados.
MAIS DE 50 ANOS DE PESQUISA SOBRE CONTRATOS PSICOLÓGICOS DE TRABALHO: SISTEMATIZAÇÃO TEÓRICA E SUGESTÃO DE AGENDA FUTURA DE PESQUISA
Authors: Chiuzi Rafael Marcus , Malvezzi Sigmar
Published: November 2020

Os contratos psicológicos de trabalho são estudados a partir da década de 1950 e, desde então, passaram por profundas transformações em sua essência e também sobre a própria operacionalização de pesquisa. Assim, o objetivo do presente artigo é apresentar uma sistematização teórica dos mais de 50 anos de pesquisa científica sobre os contratos psicológicos de trabalho a partir de um método arqueológico do saber propondo um novo conceito para o construto e uma proposta de agenda de pesquisa científica para os próximos anos.
THEATRE MARAE: Māori theatre pedagogy in research
Authors: Pearse-Otene Helen
Published: November 2020

Theatre Marae is a contemporary theatre practice unique to Aotearoa New Zealand, and this article outlines its application as an Indigenous-informed creative framework for qualitative research. As a research methodology, Theatre Marae is based in a conceptual partnership between traditional and contemporary Māori performing arts, applied theatre and the therapeutic encounter. As a form of theatre pedagogy, Theatre Marae has been applied as a decolonising strategy in ensemble work, and to craft evocative theatre that honours Māori expressions of colonisation, trauma and social justice. Theatre Marae projects have been carried out in kāinga, schools, prisons, youth justice residential centres, community centres and mainstream theatres throughout Aotearoa New Zealand. Although its creative and therapeutic outcomes are influenced by both Western and Māori psychologies and performance traditions, the underlying principles and day-to-day practice of Theatre Marae are based in te ao Māori. This configuration positions Theatre Marae as an Indigenous creative framework that is also applicable to Kaupapa Māori arts-based research.
Plan estratégico de la empresa Vivalo Import Export E.I.R.L., Lima, para el periodo 2019 - 2022
Authors:   , Valentín Cajas Kenly Augusto
Published: November 2020

El presente Plan Estratégico elaborado para la empresa Vivalo Import Export E.I.R.L. (Editorial Berlín) para el periodo 2019 – 2022, cuya actividad está basada en la producción y comercialización de coleccionables impresos (álbumes, figuritas y cards), propondrá estrategias que le permitirán seguir creciendo e incrementar su rentabilidad.
RESPONSE OF TARAKAN CITY FOREST MANAGEMENT TO ENVIRONMENTAL SUSTAINABILITY
Authors: Sutrisno Adi , Wahyu Agang Mohammad
Published: November 2020

Community activities in the city forest area have caused degradation and damage, therefore it requires a responsefrom the parties, especially the community in the area. The research aims to describe the supporting policies, the distribution of land area and cover, perceptions, participation, responses, and formulate policy implications. The methods used include qualitative content analysis, remote sensing land cover and geographic information systems and qualitative descriptive analysis using the PSR approach. The results of the research are: supporting policies including Government Regulations, Ministerial Regulations, Ministerial Decrees, Tarakan Mayor Regulations, and Tarakan Mayor Decrees the area has not been distributed proportionally with the dominance in the East Tarakan District, community perception is low which results in activities that are not in accordance with the designation of the land, giving birth to land tenure conditions and the user community does not participate in management. Residents are involved in sustainability and the policy implications of this research are the revised RTRW for the City of Tarakan and model of government and community partnership in management which are formulated and stipulated in the PERDA
Well-Posedness and Exponential Estimates for the Solutions to Neutral Stochastic Functional Differential Equations with Infinite Delay
Authors: Asker Hussein K.
Published: November 2020

In this work, neutral stochastic functional differential equations with infinite delay (NSFD-EwID) have been addressed. By using the Euler-Maruyama scheme and a localization argument, the existence and uniqueness of solutions to NSFDEwID at the state space Cr under the local weak monotone condition, the weak coercivity condition and the global condition on the neutral term have been investigated. In addition, the L2 and exponential estimates of NSFDEwID have been studied.
Ultraviolet Exposure and Photokeratitis Complaints among Informal Welding Workers in Depok, West Java, Indonesia
Authors: Yustheresani Maria K I J , Nurcandra Fajaria , Fitri Azizah Musliha , Putri Annisa Ika , Utari Dyah
Published: November 2020

One of the photokeratitis risk factors is acute reversible radiation of ultraviolet (UV) rays, which injure the cornea's epithelial tissue. Informal welding workers are susceptible populations to UV rays exposure. This study aimed to confirm the influence of UV radiation exposure on photokeratitis complaints in welding workers in Cimanggis, Depok, West Java. A cross-sectional study was conducted from February to June 2019 and used to select 100 welding workers purposively. A semi-structured questionnaire was used to determine photokeratitis complaints, age, education level, eye protection, safety knowledge, and work period; the UV radiation measured by A UV meter. Data were analyzed using a logistic regression test. We found the proportion of photokeratitis to be 84.0%, with 76.0% of UV radiation exceeding the Threshold Limit Values (TLV). The logistic regression test showed a significant effect of UV radiation on photokeratitis after controlling confounding variables (education level, eye protection, safety knowledge, and welding distance) (p-value = 0.006; AdjOR = 7.236; 95% CI: 1.74–30.07). It can be concluded that UV radiation, more than TLV, constitutes the primary risk factor for photokeratitis complaints. Risks for photokeratitis were influenced by low education level, poor eye protection, limited safety knowledge, and welding distance ≤ 45 cm.
Using the Reach, Effectiveness, Adoption, Implementation, Maintenance Framework in the Evaluation of Community-Based Adolescent Care Pilot Program
Authors: Al Aufa Badra , Sulistiadi Wahyu , Nurmansyah Mochamad Iqbal , Syiroj Agung T R , Koire Ibrahim Isa
Published: November 2020

Posyandu Remaja (Posmaja) is a community-based adolescent care service in Indonesia that comprises a group of adolescents working as volunteers and healthcare workers under the guidance and responsibility of the Public Health Centre and City Health Office. The study aims to provide a formative evaluation program of Posmaja using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. This research used a qualitative approach and took place in South Tangerang City, Indonesia. The data were collected from July until December 2018. Nineteen people participated in the study. The study used in-depth interviews and focus group discussions that adopted the RE-AIM framework for data collection. Content analysis was used to analyze the collected data. The majority of Posmaja’s participants were male adolescents aged around 15 years old. Common themes generated were “adolescent empowerment,” “increasing health knowledge,” and “monitoring health and nutrition” as a result of doing the pilot program. Volunteers and healthcare workers recognized the benefits of Posmaja and thus encouraged the adoption of the program. This awareness, followed by the city Health Office’s willingness to fund and adopt the program, was viewed as highly necessary for the program’s continuation.
Technological Features in Processing of Conical Lenses
Authors: Filonova M. I. , Dias Gonzalez R. O. , Sukhotzkiy A. A. , Kozeruk A. S. , Semchuonok A. V.
Published: November 2020

The paper presents the technology of obtaining flat-conical lenses (axicons) by the method of free grinding a work-piece to a flat tool through a layer of abrasive suspension. For this, theoretical and experimental studies of the regularities of stock removal from the base of the cone and its lateral surface have been carried out. The processing modes have been identified that ensure both uniform operation of the flat surface of  the part and enhanced removal of  the allowance in the edge or central zone of this surface. During the study of the processing of the conical surface, the set-up parameters of the technological equipment have been established, at which there is a minimum deviation of the generatrix of the cone from straightness and maximum productivity of the process. The stages of processing conical lenses are proposed, which allow to assign the optimal sequence of operations in the manufacture of this type of parts from blanks of a cylindrical shape in cases where  the ratio of the height of the cone to the diameter of its base H/d £ 0.5. The main stages of processing include: grinding of the bases of cylindrical blanks with maintaining their mutual parallelism with a given accuracy; polishing one of the cylinder bases to achieve the required roughness and deviation from non-flatness; fastening a cylindrical blank to an auxiliary plane-parallel glass plate using molecular cohesion forces; mechanical fastening of a cylindrical work-piece with a collet adapter mandrel for a plane-parallel glass plate; applying the nearest sphere to the second base of the cylindrical blank; drawing a conical surface on the spherical part of a plano-convex lens; grinding and polishing the conical surface to achieve the required roughness  and straightness of the cone generatrix. The degree of efficiency of the setup parameters of the machine has been revealed depending on the technological heredity of the work-piece from the point of view of the distribution of the allowance to be removed over the machined surface.
Reducing spread of COVID-19 in closed environments: an outbreak investigation and modelling study in dormitory settings
Authors: Pung Rachael , Lin Bernard , Maurer-Stroh Sebastian , Sirota Fernanda L , Mak Tze Minn , Octavia Sophie , Pang Junxiong , Tan Iain Beehuat , Tan Clive , Ong Biauw Chi , Cook Alex , Lee Vernon
Published: November 2020

Starting with a handful of SARS-CoV-2 infections in dormitory residents in late March 2020, rapid tranmission in their dense living environments ensued and by October 2020, more than 50,000 acute infections were identified across various dormitories. Extensive epidemiological, serological and phylogentic investigations, supported by simulation models, helped to reveal the factors of transmission and impact of control measures in a dormitory. We find that asymptomatic cases and symptomatic cases who did not seek medical attention were major drivers of the outbreak. Furthermore, each resident has about 30 close contacts and each infected resident spread to 4.4 (IQR 3.5–5.3) others at the start of the outbreak. The final attack rate of the current outbreak was 76.2% (IQR 70.6%–98.0%) and could be reduced by further 10% under a modified dormitory housing condition. These findings are important when designing living environments in a post COVID-19 future to reduce disease spread and facilitate rapid implementation of outbreak control measures.
Clinical Efficacy of Eucaloric Ketogenic Nutrition in the COVID-19 Cytokine Storm: a Retrospective Analysis of Mortality and ICU Admission
Authors: Sukkar Samir Giuseppe , Cogorno Ludovica , Pasta Andrea , Livia Pisciotta , Vena Antonio , Gradaschi Raffaella , Dentone Chiara , Guiddo Erica , Martino Eleonora , Beltramini Sabrina , Donini Lorenzo Maria , Carmisciano Luca , Sormani Maria Pia , Bassetti Matteo
Published: November 2020

Background: Some patients affected by COVID-19 present a life-threatening hyperinflammatory state known as cytokine storm syndrome (CSS) associated with a high mortality rate. Our hypothesis is that a eucaloric ketogenic diet (EKD) may be a safe and efficacious treatment option to reduce CSS and consequently to reduce the need for CPAP, ICU admission and COVID-19 mortality.Aim of the study: The primary objective is to explore the effect of an EKD on mortality, admission to the ICU and the need for NIV in hospitalized patients with COVID-19 in comparison to a eucaloric standard diet (ESD). The secondary objectives are to collect data about the safety and feasibility of an EKD during hospitalization and to evaluate the effect of the diet on biological and inflammatory parameters, particularly interleukin-6 (IL-6).Patients and methods: The study is a retrospective explorative analysis of 34 patients fed with an EKD during hospitalization for COVID-19 in comparison to 68 patients fed an ESD selected and matched using propensity score one-to-two to avoid the confounding effect of interfering variables.Results: A trend of reduced 30-day mortality (HR 0.416, 95% CI 0.122 – 1.413, P = 0.160) and a trend regarding the need for ICU admission (HR 0.357, 95% CI 0.045 – 2.847, P = 0.331) were observed in subjects treated with the EKD compared to patients fed with the standard diet. No significantly different risks in the need for CPAP (HR 0.968, CI 0.289 – 3.242, P = 0.958 for EKD) or the composite endpoint (HR 0.674, CI 0.233 – 1.949, P = 0.446 for EKD) were detectable between the two groups of dietary patterns.Furthermore, IL-6 concentrations between t 0 and t 7 (seven days after the beginning of the diet) in the ketogenic nutrition group showed a median difference of -26.0 ȵg/mL and a mean difference of -164 ȵg/mL (data from 23 of the 34 pairs) compared to controls, with a trend toward significance (P = 0.062). EKD was safe and no adverse events were observed in patients fed an EKD.Discussion and conclusions: These preliminary data on the clinical results for mortality, need for ICU admission and the effect on the IL-6 concentration during EKD feeding, collected in a retrospective way during the most aggressive period of the COVID-19 pandemic, suggest a favorable role of this dietary treatment in COVID-19 clinical management. The EKD was safe and well accepted by patients during hospitalization and seems to be an interesting tool in controlling COVID-19 CSS. The results of the prospective controlled randomized trial, currently underway with a large number of subjects, are necessary to confirm these preliminary data.
Developing A Prioritisation Framework for Patients in Need of Coronary Artery Angiography
Authors: Doshmangir Leila , Pourasghar Faramarz , Sharghi Rahim , Rezapour Ramin , Gordeev Vladimir Sergeevich
Published: November 2020

Background: Effective waiting list management and comprehensive prioritisation can provide timely delivery of appropriate services to ensure that the patient needs are met and increase equity in the provision of health services. We developed a prioritisation framework for patients in need of coronary artery angiography (CAA).Methods: We used a mixed-methods approach to elicit effective factors that affect CAA patient prioritisation. Informed by a scoping literature review and open semi-structured interviews with 15 experts, the final set of factors was selected using Delphi method. The framework was finalised during expert panel meetings. Results: 212 effective factors were identified based on the literature review, interviews, and expert panel discussion. Of them, 37 factors were selected for Delphi study. Following two rounds of Delphi discussions, seven final factors were selected and weighed by ten experts using pair-wise comparisons. The following weights were given: the severity of pain and symptoms (0.22), stress testing (0.18), background diseases (0.15), number of myocardial infarctions (0.15), waiting time (0.10), reduction of economic and social performance (0.12), and special conditions (0.08).Conclusion: Clinical effective factors were important for CAA prioritisation framework. Using this framework can potentially lead to improved accountability and justice in the health system.
Enantioselective Construction of Six- and Seven-Membered Triorgano-Substituted Silicon-Stereogenic Heterocycles
Authors: He Chuan , Chen Shuyou , Mu Delong , Mai Pei-Lin , Ke Jie
Published: November 2020

A rhodium-catalyzed enantioselective construction of six- and seven-membered triorgano-substituted silicon-stereogenic heterocycles is developed. This process undergoes a direct dehydrogenative C−H silylation, giving access to a wide range of novel triorgano-substituted silicon-stereogenic heterocycles in good to excellent yields and enantioselectivities, that significantly enlarged the chemical space of the silicon-centered chiral molecules. Further elaboration of the chiral monohydrosilane product delivered various corresponding tetraorgano-substituted silicon-stereogenic heterocycles without the loss of enantiopurity. These novel silicon-bridged heterocycles exhibit bright blue fluorescence, which would have potential application prospects in organic optoelectronic materials.
Lysine metabolism conveys kidney protection in hypertension
Authors: Rinschen Markus , Palygin Oleg , Golosova Daria , Domingo-Almenara Xavier , Palermo Amelia , Schafroth Michael , Guijas Carlos , Gliozzi Megan , Xue Jingchuan , Höhne Martin , Benzing Thomas , Kok Bernard , Saez Enrique , Bleich Markus , Himmerkus Nina , Weisz Ora , Cravatt Benjamin , Krüger Marcus , Benton H. Paul , Siuzdak Gary , Staruschenko Alexander
Published: November 2020

Hypertension and kidney disease, two related, common, and severe disease entities, have been repeatedly associated with genomic variants and metabolic alterations of lysine metabolism. Here, we developed a stable isotope labeling strategy compatible with untargeted metabolomics acquisition to investigate the physiology and molecular spectrum of lysine’s metabolic fate in vivo. Mice received 13C6 labeled lysine through the diet over two months to track more than 100 lysine metabolites across various organs and body fluids. Lysine reacts rapidly with molecules of the central carbon metabolism, as opposed to slow or incorporation into proteins and metabolization into acylcarnitines. The kidney rapidly forms these lysine conjugates and lysine metabolism is decreased in early stages of hypertension. Lysine administration completely diminished the development of salt-sensitive hypertension and kidney injury in the Dahl salt-sensitive rat model. Administration of lysine leads to diuresis, acceleration of 13C6 lysine conjugate formation, and inhibition of albumin uptake, thereby protecting from nephron injury and metabolic stress. Lysine conjugates with malonyl-CoA to form a novel metabolite Ne-malonyl-lysine to inhibit fatty acid synthesis. Formation of Ne-malonyl-Lysine, and acetyl-Lysine during lysine treatment depletes malonyl-CoA and acetyl-CoA, respectively, a process that occurs at the expense of protein malonylation and acetylation. A significant fraction of lysine molecules was metabolized in the kidney and excreted as fructoselysine and saccharopine, via the urine, leading to an overall depletion of central carbon metabolites from the organism. A ketogenic diet also ameliorated hypertension, yet to a lower extent, and increased several lysine conjugates, including Ne-malonyl-lysine. In conclusion, isotope tracing of orally administered lysine illuminated lysine metabolism, and L-lysine protects the kidneys in metabolically defined subtypes of kidney disease.
Gamma-ray Bursts Cosmology with The X-ray Fundamental Plane Relation
Authors: Dainotti Maria , Fernandez Jacob , Saraccino Giuseppe , Lenart Aleksander , Postnikov Sergey , Nagataki Shigehiro , Fraija Nissim
Published: November 2020

Cosmological models and the value of their parameters are at the center of the debate because of the tension between the results obtained by the SNe Ia data and the Plank ones of the Cosmic Microwave Background Radiation. Thus, adding cosmological probes observed at high redshifts, such as Gamma-Ray Bursts (GRBs), is needed. Using GRB correlations between luminosities and a cosmological independent variable is challenging because GRB luminosities vary widely. We corrected a tight correlation between the rest-frame end time of the X-ray plateau, its corresponding X-ray luminosity, and the peak prompt luminosity: the so-called fundamental plane relation, using the jet opening angle. Its intrinsic scatter is 0:017 m 0:010 dex, 95% smaller than the isotropic fundamental plane relation, the smallest compared to any current GRB correlation in the literature. This shows that GRBs can be used as reliable cosmological tools. We use this GRB corrected correlation for the so-called platinum sample (a well-defined set with relatively flat plateaus), together with SNe Ia data, to constrain different cosmological parameters like the matter content of the universe today, M, the Hubble constant H0, and the dark energy parameter w for a wCDM model. We confirm the wCDM model but using GRBs up to z = 5, a redshift range much larger than one of SNe Ia.
Klebsiella pneumoniae pneumonia in patients with rheumatic autoimmune diseases: clinical characteristics, antimicrobial resistance and factors associated with extended-spectrum β-lactamase production
Authors: Liu Yang , Liu Yecheng , Dai Jiayuan , Liu Anlei , Li Yi , Xu Jun , Yu Xuezhong , Liu Jihai , Zhu Huadong
Published: November 2020

Background: Over the past decades, Klebsiella pneumoniae (K. pneumoniae) infections have been increasing and affected immunocompromised patients nosocomially and communally, with extended-spectrum β-lactamase (ESBL) production becoming a major concern. Patients with rheumatic autoimmune diseases, mostly receiving immunosuppressive therapy, are vulnerable to various infections, including K. pneumoniae. However, few have investigated K. pneumoniae infections in this specific population. This study aimed to identify factors associated with ESBL production and mortality of K. pneumoniae pneumonia among patients with rheumatic autoimmune diseases in the Emergency Department. Methods: We retrospectively investigated patients with rheumatic diseases who were diagnosed with pneumonia, with K. pneumoniae isolated from their respiratory tract samples. Prognostic factors and risk factors for ESBL production were determined with univariate and multivariate logistic regression analysis. Empirical therapy and antimicrobial susceptibility data were also collected. Results: Of 477 K. pneumoniae pneumonia patients, 60 were enrolled into this study. The in-hospital mortality was 28.3%. Septic shock, ICU admission, the need for mechanical ventilation and change of antibiotics due to clinical deterioration, all related to mortality, were included as unfavorable clinical outcomes. Multivariate analysis suggested that ESBL production (OR, 6.793; p = 0.012), initial PCT≥0.5 ng/ml (OR, 5.024; p = 0.033) and respiratory failure at admission (OR, 4.401; p = 0.046) predicted increased mortality. ESBL production was significantly associated with dose of corticosteroids (OR, 1.031; p = 0.013) and CMV viremia (OR, 4.697; p = 0.043), instead of previous hospitalization and antibiotic use, in patients with rheumatic autoimmune diseases. The most commonly used empirical antibiotic was ceftazidime, while most isolates showed less resistance to carbapenems and amikacin in susceptibility testing. Conclusions: K. pneumoniae pneumonia could be life-threatening in patients with rheumatic autoimmune diseases. Our findings suggested that ESBL production, initial PCT≥0.5 ng/ml and respiratory failure at admission were independent factors associated with poor prognosis. Dose of corticosteroids and CMV viremia, predicting ESBL production in K. pneumoniae pneumonia, may help make individualized antibiotic decisions in clinical practice.