bluuebunny/crossref_metadata_2025 huggingface dataset:
Causes of Revision Total Hip Arthroplasty in Twenty Years: an Analysis of 1,353 Revisions 
Authors: Gu Jianming , Feng Xiao , Shao Hongyi , Zhou Yixin
Published: September 2020

BackgroundWith the increase in revision total hip arthroplasty (THA) cases, understanding its causes is essential for a surgeons' clinical decision-making. Studies have reported on revision THA epidemiology in developed countries; however, its epidemiology in China remains unclear. We reviewed revision THA causes in a tertiary center in China. MethodsWe retrospectively identified 1,353 revision THAs at our institution from January 1999 to December 2018 (20 years). The causes for revision THA were compared among patients who were grouped based on the time of revision surgery, age at revision, and number of revisions, using the Student's t-test. ResultsAseptic loosening (826 hips, 61.0%) and infection (151 hips, 11.2%) were the most common reasons for revision THA. Compared with the number of cases from January 1999 to December 2008, the number of cases from January 2009 to December 2018 increased 2.4-fold; the proportion of revisions due to aseptic loosening, periprosthetic fracture, instability, and osteolysis increased, and infection rate decreased. The infection rate was higher among patients aged over 60 years, whereas the incidence rate of aseptic loosening, periprosthetic fracture, and instability was higher among those aged 60 years or less. Infections (52.8%) were more common than aseptic loosening (37.4%) in second or subsequent revisions.ConclusionAseptic loosening and infection remain the most common causes of revision THAs at our center. Although the proportion of infections has decreased in the recent decade, a national database is necessary for a more comprehensive understanding of the causes of revision THAs in China. This work provides an understanding and comparison of the causes of revision THA in an orthopedic center among the Chinese population. This may reveal a potential change in revision THAs causes in the future, reminding surgeons to find a proper way to treat them.
Prevalence of GII.4 Sydney Norovirus Strains and Associated Factors of Acute Gastroenteritis in Children: Winter 2019-2020 in Guangzhou
Authors: Luo Mingyong , Duan Lei , Yang Xiaohan , Xie Jia , Zhan Wenli , Zhang Changbin , Liu Hong , Wei Mengru , Tang Yuan , Zhao Hongyu
Published: September 2020

BackgroundNorovirus, the leading cause of non-bacterial acute gastroenteritis (AGE) worldwide, is constantly mutating. Continuous monitoring of the evolution of epidemic genotypes and emergence of novel genotypes is therefore necessary. This study determined the prevalence and clinical characteristics of norovirus strains in AGE in Guangzhou, China in 2019-2020 winter.MethodsThis study included children aged 2-60 months diagnosed with AGE in Guangzhou Women and Children Hospital, from August 2019 to January 2020. Norovirus was detected by real-time polymerase chain reaction and clinical data were obtained. Genotyping and phylogenetic analyses were performed with partial gene sequence fragments located at the open reading frames 1-2 junctions.ResultsDuring the study period, 168 children (61.3% males) were confirmed as norovirus infectious AGE. The main symptoms were diarrhoea and vomiting; and 38 patients (22.6%) had seizures. Norovirus was mainly prevalent in October and November, and GII.P31/GII.4 Sydney was the major genotype circulating in Guangzhou. The phylogenetic tree showed that the Guangzhou strains had high homology with the strains circulating in 2017-2019 worldwide. ConclusionsGII.4 Sydney was the main prevalent norovirus genotype in Guangzhou from August 2019 to January 2020, which had more severe diarrhoea than those of other genotypes. These findings provide a valuable reference for the prevention, control, and treatment of norovirus in the future.
LINC00680 Modulates Docetaxel Resistance in Breast Cancer via miR-320b/CDKL5 Axis
Authors: LI JIA , KE JIN , Qin Cheng-lin , Zhu Xun
Published: September 2020

BackgroundThe purpose of this study was to explore regulatory mechanism of the long non-coding RNA LINC00680 underlying the breast cancer chemoresistance via miR-205/CDKL5 axis. MethodsBioinformatics methods were applied to screen lncRNAs, miRNAs and mRNAs for construction of a competing endogenous RNA network. Dual-luciferase reporter assay were used to explore the relationship between LINC00680, miR-320b and CDKL5. CCK-8 assay and Transwell assay were utilized to evaluate the proliferation, migration and invasion in docetaxel-resistant cells.ResultsLINC00680 and CDKL5 protein levels were both up-regulated when induced by different concentration of docetaxel. LINC00680 knockdown decreased the expression level of drug resistance related genes (MDR1, MRP5, LRP1), proliferation, invasion of breast cancer cells. Bioinformatics prediction and dual-luciferase assay reveled that miR-320b both targeted the 3’-UTR of LINC00680 and CDKL5, suggesting that the modulation of LINC00680 on CDKL5 through sponging miR-320b. ConclusionsOverall, the results indicate the important role of LINC00680 in the docetaxel resistance through miR-320b/CDKL5 pathway, providing a novel therapy strategy for breast cancer drug resistance.
Improvement of Xylose Utilization and L-ornithine Production by Metabolic Engineering of Corynebacterium glutamicum
Authors: Gao Ge , Zhang Yan , Zhou Ying , Ye Bang-Ce
Published: September 2020

Background: L-ornithine is a basic amino acid, which shows significant value in food and medicine industries. Xylose is the most important alternative carbon source of glucose in lignocellulosic hydrolysate. It is urgent to develop a high-efficiency cell factory for L-ornithine production with glucose and xylose.Results: In this study, the genes enconding xylose isomerase and xylulose kinase were introduced into Corynebacterium glutamicum S9114 to establish xylose metabolism pathway, and then xylose became a substitute carbon source of glucose. In addition, the optimization and overexpression of phosphoenolpyruvate carboxylase and pentose transporter had been conducted to promote the synthesis of L-ornithine for the first time. Furthermore, though optimizing the concentration ratio of glucose and xylose (7:3), adding biotin and thiamine hydrochloride, we arrived at the highest L-ornithine yield 41.5g/L in shaking flask fermentation so far.Conclusions: Our results demonstrate that the combination of metabolic engineering and the optimization of fermentation process can make great potential for L-ornithine production by lignocellulose hydrolysate.
Effects on the mental health after COVID-19 lockdown period: results from a population survey study in Lima, Peru
Authors: Krüger-Malpartida Hever , Pedraz-Petrozzi Bruno , Arevalo-Flores Martin , Salmavides-Cuba Frine , Anculle-Arauco Victor , Dancuart-Mendoza Mauricio
Published: September 2020

1. The coronavirus disease 2019 (COVID-19) has created a rapid global health crisis, involving different social changes, which brought negative effects in different aspects in the mental health of the population, like the COVID-19 lockdown. The majority of COVID-19 cases concentrate in the region of the Americas, being Peru one of the most affected countries in the region. For this reason, to investigate possible effects related to COVID-19 lockdown, the main objective of this work is to establish a statistical model that could explain through different components the COVID-19 related stress in a population after COVID-19 lockdown of Lima, Peru. In this sense, online questionnaires were carried out in 400 participants, where the values ​​of depressiveness, anxiousness and stress related to COVID-19 were evaluated. Other information related to the participant (e.g. gender, age, district, etc.) was collected through this electronic format. In order to explain the data, an ordinal logistic regression was carried out. From the information obtained, it was found that 35.50% of the participants showed mild stress and 9.30% showed severe stress due to COVID-19. The ordinal logistic regression model showed that the severity of stress due to COVID-19 is positive associated with the variables age, depressiveness and anxiousness, as well with the presence of a deceased relative due to COVID-19. On the other hand, the presence of a family member who was hospitalized for COVID-19 is negatively correlated to the stress produced by COVID-19. Therefore, the data shows that people with older age or who have lost relatives due to COVID-19 show higher levels of stress related to COVID-19. Additionally, participants with higher levels of anxiety and depression are more likely to produce higher levels of stress from COVID-19. These factors play an important role for the intervention of future studies that plan to intervene in the mental health of the population affected by the COVID-19 lockdown.
Intensive Greenhouse Vegetable Production Decreases Spatial Turnover and Increases Stochasticity of Soil Bacterial Communities
Authors: Zhou Xingang , Rahman Muhammad Khashi u , Liu Jiayao , Wu Fengzhi
Published: September 2020

Background: Soil microorganisms regulate many critical ecosystem processes and understanding how soil microbial communities respond to anthropogenic disturbance, such as land-use change, is of great ecological importance. However, the effects of land-use change on soil microbial community assembly processes at regional scale are still poorly understood. Using 16S rRNA gene sequencing and quantitative PCR analysis, we characterized soil bacterial community assembly in agricultural fields with different land-use types, (1) open field cultivated with main crops or (2) vegetables, and (3) greenhouse cultivated with vegetables. Greenhouse vegetable production was more intensive than other two use types.Results: Greenhouse vegetable production decreased the alpha diversity and changed the composition of soil bacterial community. Co-occurrence network and cohesion analyses showed that the bacterial community was less closely interconnected under greenhouse conditions. Land-use type sensitive OTUs were taxonomically diverse, and responded differently to changes in edaphic variables and showed different co-occurrence patterns. The spatial turnover rates of habitat and bacterial community were lower for greenhouse cultivated with vegetables. Null model analysis found that the bacterial community assembly was mainly governed by deterministic processes; however, bacterial community in greenhouse soils was phylogenetically less clustered and was more sensitive to stochastic processes. Soil pH was the major factor in shaping bacterial community structure and mediating the balance between stochastic and deterministic processes.Conclusions: Overall, this study revealed that agricultural intensification led to loss of biodiversity and homogenization of soil bacterial communities across spaces. Moreover, intensive greenhouse vegetable production decreased the habitat heterogeneity, eventually lowering the habitat preference, and thus increased the relative importance of stochastic processes. These findings enhance our understanding of how soil bacterial communities respond to anthropogenic disturbance, and may provide crucial implications for improving soil quality and agroecosystem sustainability.
The Investigation of the Relationship Between the Inherited Thrombophilia and Novel Coronavirus Pneumonia
Authors: Kiraz Aslihan , Guzeldag Seda , Eren Esma , Goksu Musa , Bayram Arslan
Published: September 2020

Purpose: Novel coronavirus pneumonia (NCP) is a disease caused by severe acute respiratory syndrome coronavirus 2 virus. It was reported that there is a relationship between severe NCP and hypercoagulable conditions that predispose patients to thrombosis. Thrombophilia is a multifactor condition that can result from genetic factors, acquired factors, or a combination of both. The prothrombin gene (F2 rs1799963 known as G20210A), Factor V Leiden (F5 rs6025 known as G1691A) and PAI-1 (rs1799768) are important polymorphic biomarkers of thrombophilia that are investigated in severe NCP patients within this study.Methods: NCP-diagnosed 62 previously healthy male patients (mean age 38.83±11.04) without any chronic disease were enrolled in this study for the investigation of the well-known thrombophilia-related abovementioned polymorphisms. The diagnosis of NCP was made according to the World Health Organization interim guidance and confirmed by RNA detection. SNPs were detected by real-time PCR. The frequency of genotypes was compared with healthy control group frequencies from other studies performed in the Turkish population.Results: There were no statistically significant differences between the severe patient group and the healthy population regarding the investigated SNPs.Conclusion: This study is the first to rule out the relationship of rs1799963 (FII), rs6025 (FV) and rs1799768 (PAI-1) with severe NCP. As there is an obvious relation between severe NCP and genetic thrombophilia susceptibility, studies focused on other thrombophilia-related genetic factors and this disease must be performed.
Reversible Lesion of the Corpus Callosum Associated With COVID-19: A Case Report and Review of Literature
Authors: Gemici Yagmur Inalkac , Tasci Irem
Published: September 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect the central nervous system (CNS) and peripheral nervous system (PNS). Major CNS manifestations of SARS-CoV-2 include seizures, meningitis, meningoencephalitis, ischemic stroke, hemorrhagic stroke, anosmia, hypogeusia, acute disseminated encephalomyelitis, hemorrhagic necrotizing encephalopathy, and nonfocal phenomena including lethargy, agitation, confusion, headache, and ataxia. The reversible splenial lesion syndrome (MERS) was first described in 2004. Although MERS was initially recognized as a benign phenomenon, a second type of MERS was identified in later years, which has a poor prognosis and potentially serious sequela. MERS can be caused by numerous etiologies including viruses. In this report, we present a patient with SARS-CoV-2 who presented with ataxia and dizziness as the clinical symptoms of MERS, which is a rare clinical phenomenon and can be caused by numerous etiologies.
Tetanus toxoid immunization Coverage and associated factors in Ethiopia: A systematic review and meta-analysis.
Authors: Nigussie Jemberu , Girma Bekahegn , Molla Alemayehu , Mareg Moges
Published: September 2020

Background: Tetanus is a bacterial disease caused by the bacterium Clostridium tetanus which is a highly fatal, non-communicable, and toxin-mediated disease. Globally, both maternal and neonatal tetanus is a public health problem due to low maternal tetanus toxoid vaccination. The main strategies for the prevention of maternal and neonatal tetanus at birth were vaccination of the mothers with a protective dose of tetanus toxoid and clean delivery. Ethiopia has the highest neonatal mortality and morbidity related to tetanus in the world due to low tetanus toxoid immunization coverage and a higher number of home-deliveries. The main aim of this systematic review and meta-analysis was to estimate the pooled tetanus toxoid immunization coverage and associated factors in Ethiopia. Methods: The primary studies for this review were searched from PubMed/MEDLINE online, Science Direct, and Hinari databases. We retrieved 212 records; of these, 199 articles were excluded due to different reasons, and 13 studies were included in the systematic review and this meta-analysis. The data were extracted in Microsoft Excel format and exported to STATA Version 14.0 statistical software for analysis. Heterogeneity was evaluated by the I2 test. A random-effect meta-analysis model was used to estimate the pooled coverage of two or more tetanus toxoid immunization and its associated factors. Egger’s weighted regression and Begg’s rank correlation test were used to assess publication bias at a 5% significance level. Result: The pooled estimate of at least two dose of tetanus toxoid immunization coverage was 52.6% (95% CI 41.4%–63.8%). Ante-natal care (ANC) visits [OR = 7.8 (95% CI; 3.2, 19.2)], media exposure [OR = 8.3 (95% CI; 2.1. 33.3), distance from the health facility [OR = 2.635 (95% CI; 1.1, 6.6)], educational status of mothers [OR = 0.225 (95% CI; 0.105, 0.483) and husband educational status [OR = 0.184 (95% CI; 0.104, 0.323)] were significantly associated factors for tetanus toxoid immunization coverage in Ethiopia.Conclusion: The tetanus toxoid immunization coverage among childbearing women was low in Ethiopia. Strengthening maternal health service utilization (ANC, institutional delivery) to the nearest health facility including in health posts and empowering education is recommended to increase tetanus toxoid immunization coverage. Additionally, awareness creation on the advantage of taking tetanus toxoid immunization should be emphasized.
Adolescent motherhood in rural Nepal: passive sensing data illuminates daily experiences in maternal lives
Authors: Hagaman Ashley , Mercado Damaris Lopez , Poudyal Anubhuti , Bemme Dorte , Boone Clare , Heerden Alastair van , Byanjankar Prabin , Maharjan Sujen Man , Thapa Ada , Kohrt Brandon A
Published: September 2020

Background: Adolescent pregnancy, particularly in low-income settings, is associated with adverse health and social outcomes for both mother and child. Nepal has the second highest rate of adolescent pregnancy in South Asia alongside high rates of maternal depression and suicide. While the maternal morbidity risks of adolescent pregnancy are well researched, impacts on everyday lives, including behaviors and predictable patterns are less well-known. Passive sensing (geographic movement, physical activity, and proximity to infants using Bluetooth technology) is an emerging technology that can enhance the detection of behavior patterns. Given the risk of the postpartum period in LMIC settings, we sought to characterize normal behavioral patterns via passive sensing technology. Methods: We collected passive data over a two-week period with 22 mothers using phone-based GPS, accelerometry, and Bluetooth technologies. Passive data was aggregated for each mother, collapsed into hourly readings, and descriptively summarized. We triangulated this information in a constant comparative approach with a range of qualitative data including multiple in-depth interviews, a daily diary, and systematic fieldnotes. Results: Passive data illuminated a range of behaviors that varied across our participants. Women, during the average time window of 4am and 8pm, spent more than 80% of the day with their infants, were detected as ‘active’ 10-20% of the time in any given hour with peaks in the morning and mid-afternoon, and traveled fewer than 1675 meters from their homes. Household work, instrumental childcare, and household support, paired with the infant’s age, appeared to drive activity patterns. Women with higher amounts of activity and GPS movement had more household support for chores and childcare. Women with young infants had smaller amounts of activity and GPS movement. Women that had nearly no time away from their infant expressed overwhelming responsibilities and increased stress, but also role fulfillment in that time with their infant was an indicator of good mothering. Conclusion: We reveal typical behavioral patterns of rural adolescent mothers and highlight opportunities for integrating this information to improve health and well-being.
Correlations of IL-6, IL-6R, IL-10 and IL-17 gene polymorphisms with the prevalence of COVID-2019 infection and its mortality rate 
Authors: Batur Lutfiye Karcıoğlu , Hekim Nezih
Published: September 2020

The pathogenesis of COVID-19 implicates a potent inflammatory response resulting in cytokine storm. We aimed to evaluate association between polymorphisms in IL-6 gene at rs1800796/rs1800795, IL-6R at rs2228145, IL-10 at rs1800896 and rs1800871, IL-17 at rs2275913 and rs76378, and the prevalence (per million) and mortality rates (per million) of COVID-19 among populations of China, Japan, India, Iran, Spain, Italy, Mexico, Netherlands, Sweden, Turkey, Finland, Brazil, Czechia, Russia, Poland. AG and GG genotypes of rs2275913 in IL-17A was found to be correlated with prevalence and mortality rates, especially in Spain and Brazil populations (p<0.05) while TT genotype of rs763780 in IL-17F was not dependent on the high frequencies in all populations. However, the polymorphisms in IL-6, IL-6R and IL-10 appear not to be correlated with prevalence and mortality rates. The variations in the prevalence of COVID-19 and its mortality rates among countries may be explained by cytokine storm differed by the polymorphisms of rs2275913 locus in IL-17A gene. However, the prevalence of infection differs from severity of COVID-19, based on many factors such as public awareness, behaviors and antiviral policy of countries. Yet, the severity of disease induced by viral infection might be associated with genetic host factors including immune profiling.
An Updated Host Differential Due to Two Novel Races of Diplocarpon rosae Wolf, the Causal Agent of Rose Black Spot Disease
Authors: Zlesak David C. , Ballantyne Darcy , Holen Matthew , Clark Andrea , Hokanson Stan C. , Smith Kristen , Zurn Jason D. , Bassil Nahla V. , Bradeen James M.
Published: September 2020

The fungal pathogen, Diplocarpon rosae, infects only roses (Rosa spp.) and leads to rose black spot disease. Rose black spot is the most problematic disease of outdoor-grown roses worldwide due to the potential for rapid leaf chlorosis and defoliation. Eleven races of the pathogen were previously characterized from isolates collected in North America and Europe. Isolates of D. rosae obtained from infected leaves of the roses Brite EyesTM (‘RADbrite’; isolate BEP; collected in West Grove, PA) and Oso Easy® Paprika (‘CHEwmaytime’; isolate PAP; collected in Minneapolis, MN) proved to have unique infection patterns using the established host differential with the addition of Lemon FizzTM (‘KORlem’). The new races are designated race 12 (BEP) and race 13 (PAP), respectively, and Lemon FizzTM should be included in the updated host differential because it distinguishes races 7 and 12. Additionally, inconsistent infections and limited sporulation were found in the host differential Knock Out® (‘RADrazz’) for races 7 and 12. Expanding the collection of D. rosae races supports ongoing research efforts, including host resistance gene discovery and breeding new rose cultivars with increased and potentially durable resistance.
Sowing Green Seed Without Stratification Does Not Shorten Juvenility or Increase Plant Size in Common Lilac (Syringa vulgaris)
Authors: Hoskins Tyler C. , Lattier Jason D. , Contreras Ryan N.
Published: September 2020

Common lilac is an important flowering shrub that accounts for ≈$20 million of sales in the U.S. nursery industry. Cultivar improvement in common lilac has been ongoing for centuries, yet little research has focused on shortening the multiple-year juvenility period for lilacs and the subsequent time required between breeding cycles. The practice of direct-sowing of immature “green” seed has been shown to reduce juvenility in some woody plants, but it has not been reported for common lilac. This study investigated the effects of seed maturity [weeks after pollination (WAP)], pregermination seed treatment (direct-sown vs. cold-stratified), and postgermination seedling chilling on the germination percentage, subsequent plant growth, and time to flower on lilac seedlings. All seedlings were derived from the female parent ‘Ludwig Spaeth’ and the male parent ‘Angel White’. Seeds harvested at 15 and 20 WAP resulted in 58% (sd ± 9.9%) and 80% (sd ± 9.0%) germination, respectively, which were similar to that of dry seed collected at 20 WAP with stratification (62% ± 4.2%). Seedlings from the green seed collected at 15 and 20 WAP were also approximately three-times taller than those of dry seed groups DS1, DS2, and DS3 after the first growing season. Over the next two growing seasons, there were no differences in seedling height across all treatments. Flowering occurred at the beginning of the fourth season and without differences among treatments. These results indicate that the collection and direct sowing of immature, green seed can be used to successfully grow lilac seedlings, but that they do not reduce the juvenility period. However, this method can provide more vegetative growth in year one to observe early vegetative traits such as leaf color, and it can provide more material for DNA extraction to support molecular research.
ARABIC LEARNING AND RELIGIOUS CONVERSION
Authors: Bahry Abdul-Rahman
Published: September 2020

The government of the State of Ohio has designed mandatory programs to help NRC’s female inmates to prepare themselves upon their release back to the community; one of the programs is Islamic education for Muslim prisoners. This program reserves as an opportunity for Muslim missionary (dai) for exercising dakwah (Islamic proselytization) activism, not only for Muslim prisoners, but also as a gate to introduce Islam to non-Muslim inmates. Particularly for the non-Muslim prisoners, they are interested in studying reading and writing Arabic as they are voluntarily joining the Arabic class. This article tries to over a new perspective on Islamic education and dakwah activism. Taking a close look at the lives of prisoners at the state prison of Ohio, this article mainly discusses the intermingled sphere of Islamic education for the Muslim and religious conversion. It further argues that teaching Arabic resorts as a gate for Muslim missionary to introduce Islam for Muslim prisoner who voluntarily participated in this language class and religious conversion to Islam often follows their participation. Thus, as the discussion of this article demonstrates, there has been a close connectivity between the ‘neutral’ language class with religious conversion.
THE LIVING MUSLIM ETHICS IN CHARACTER EDUCATION
Authors: Nafis Muhammad Muntahibun
Published: September 2020

This paper examines character education as discussed through Kitab Adab al-‘Alim wa al-Muta’allim by the founder of the largest Muslim organization in Indonesia, Nahdlatul Ulama, Kiai Hasyim Asy’ari (1871-1947). It tries to locates character education as the transformation of Muslim subjects as the foundation of social piety. The article further argues that Kiai Hasyim Asy’ari through his work had laid a comprehensive Islamic values that are parallel to principles of character education. The core values of Islamic character education centers on the notions of rabbaniyah (godness), insaniyah (humanity), wasathiyyah (moderateness) and waqi’iyyah (reality). Therefore, Kitab Adab al-‘Alim wa al-Muta’allim reserves as a pesantren-based character education with a particular reference of creating a Muslim subject with social-piety element.
ISLAMIC ETHICS IN SOCIAL MEDIA
Authors: Desi Erawati Lisnawati;
Published: September 2020

This article addresses social media, family life and its intersection with Islamic ethics. It particularly discusses the use of social media to protect harmony of family life as to which communication ethics on social media for married-couples to prevent family disharmony. A close look at sources ranging from Islamic sources, magazines, newspapers, official documents of the local religious court (Pengadilan Agama), this article argues that there are seven communication ethics through social media crucial to prevent disharmony. These seven are to take benefits and to leave losses, meaning that social media has benefits if used wisely; to practice fair time management; to be open with your partner; to select friends wisely; to say corresponding statement in posts and comments; to keep the couple’s disgrace and not to indulge themselves on social media; and to look after self-esteem.
INSTITUTIONAL IMPROVEMENT OF AN INDONESIAN ISLAMIC HIGHER EDUCATION
Authors: Chotimah Chusnul
Published: September 2020

Scholarly discussions on institutional development could be divided into two categories; “Blue Ocean Strategy” and “Red Zone Strategy” approaches. Blue Ocean Strategy characterized by creating new innovation and market without locating institution to compete with other institution. Meanwhile, Red Zone Strategy emphasizes on initiating a different innovation in order to contest in the marketplace. This article examines the transformation of IAIN Tulungagung from STAIN to IAIN in 2013. This article employs qualitative approach and demonstrates that IAIN Tulungagung has created a creative innovation such as initiating Edu-fair event to attract new students, bulding a new brand, establishing the advance program to promote its institution, and developing the human capital. This strategy indicates that IAIN Tulungagung applies Blue Ocean Strategy in developing its institution such as Decrease-Delete-Create-Increase becomes Passive-Save-Create-Increase.
A HISTORY OF Hadrami COMMUNITY IN SOUTHEAST ASIA
Authors: Subchi Imam
Published: September 2020

Hadrami-Arabs have played essential roles in Islamisation process across Southeast Asian region. This article diachronically examines the history of Hadrami community and their roles in islamisation. It looks at the dynamics, adaptation, and contestation of Islamisation in the region. This article offers actors-centered accounts of how the Hadrami community contributes to Islamic proselitisation activism (dakwah), politics, and contestation within the community. It further argues that, throughout the history of Hadrami in Southeast Asia, political adaptation and contestation have been essential elements that shape the current Islamic-scape in contemporary Southeast Asia.
MODERNISING THE DAYAH
Authors: Nur Ismet
Published: September 2020

The Acehenese Islamic educational institution, dayah, has played a major role in institutionalisation of Islam among the Acehness. the development of diversity in community. As a traditional institution, the dayah system has developed and successfully translated principles of modernity through the establishment an integrated educational system. This article examines the modernization of Darul Mukhlisin in Central Aceh and its characteristic in modernising its educational system. The modernization of the education system is characterized by changes in the aspects of objectives, Teungku and the students (santri) of dayah, implementation of an integrated curriculum, the treasury of contemporary books, use of active strategies and varieties of educational methods, environmental changes, the application of test and non-test evaluation types, and so forth. This article further argues that the Darul Mukhlisin has been successfully adopting the dayah system into modern principles of modern management in educational institution. The Darul Mukhlisin resorts as an important agent for religious education, producing learned Muslims who contributes to the development of the Acehness.
Construction and Standardization of Examination Anxiety Scale for Adolescent Students
Authors: ABBASİ Nargis , GHOSH Shilpi
Published: September 2020

This research paper describes the method of construction and standardization of a tool to measure examination anxiety of adolescent students. 2030 students belonging to the age group of 13-15 years from 19 schools under West Bengal Board of Secondary Education, participated in this research. The first draft of examination anxiety scale consisted 40 items. After reviewing the items and item analysis, the number of items were reduced to 38. EFA was carried out on obtained data. EFA revealed that total 21 items having factor loading greater than .40, are selected. They distributed under four factors such as, Bodily symptoms, Cognitive, Emotional reaction and behavioural reaction. CFA was executed on another sample group, consisted of 402 number of adolescent students of age group13-15. CFA results also supported the results of EFA. All the goodness of fit indices showed that the model is a good fit model. For concurrent validity, Examination Anxiety Scale made by researcher and Test Anxiety Inventory by Spielberger were administered on the same occasion on 110 school students of the age group13-15. Coefficient of correlation of two scales was estimated. The validity of Examination anxiety Scale is 0.71. The reliability coefficient of the examination anxiety scale using test-retest, split half and Cronbach’s alpha methods were 0.801, 0.767, 0.764 respectively. Norms show that 16 percent of the students belong to the high examination anxiety group, 66 percent of the students in average examination anxiety group and 18 percent in low examination anxiety group.
Does currency smirk predict foreign exchange return?
Authors: Hoque Ariful , Ngoc Quynh Le Thi , Hassan Kamrul
Published: September 2020

This study examines the predictive power of implied volatility smirk to forecast foreign exchange (FX) return. The volatility smirk contains critical information, especially when the market experiences negative news. The Australian dollar, Canadian dollar, Swiss franc, Euro, and British pound options traded in the opening, midday and closing periods of the trading day are selected to estimate the currency smirk. Research results reveal that the currency smirk outperforms in forecasting FX returns. In addition, the steeper slope in the middle of the trading day suggests that the predictive power of currency smirk in the midday period is higher compared to the opening and closing periods. However, currency smirks’ predictability lasts for a short period, as the FX market is highly adept at incorporating the vital information embedded in the currency smirk. These findings imply that the currency smirk is distinctive for forecasting very short-term FX fluctuations, and the day- or overnight FX traders can use its uniqueness to profit from quick price swings in the 24-hour global FX market.
A Organização do Conhecimento no RPG eletrônico por meio de ontologias
Authors: Miranda Marcos Luiz Cavalcanti de , Santos Samantha Alves Rodrigues dos
Published: September 2020

Investiga a Organização do Conhecimento e sua aplicação aos jogos eletrônicos, expondo os desafios e problemas desta atividade. Propõe a ontologia como uma forma de Organização do Conhecimento adequada para representar materiais nascidos no formato digital, de acordo com o paradigma da Web Semântica. Utiliza como recorte temático o estudo prático do gênero de jogos eletrônicos chamado RPG (Role-Playing Game), expondo suas características, elementos e hierarquias. Emprega como método a pesquisa exploratória, onde o conteúdo da Organização do Conhecimento é abordado, desde a definição do que é a Organização do Conhecimento, o que é o conceito, o que é um Sistema de Organização do Conhecimento e o que é uma ontologia, até a parte específica sobre os jogos eletrônicos e suas especificidades na representação. Oferece uma aplicação do conteúdo pesquisado, por meio de uma análise facetada dos jogos eletrônicos aplicada à construção de uma ontologia, sendo essa construção feita experimentalmente passo-a-passo. Aborda o potencial da ontologia ilustrando com o exemplo da aplicação da ontologia à organização dos jogos de RPG eletrônico.
Caminhos algorítmicos
Authors: Medeiros Jackson da Silva
Published: September 2020

Este trabalho parte da ideia que é necessário questionar e compreender como os algoritmos atuam na constituição do sujeito. Através da abordagem de sociedade de controle, apresentada por Gilles Deleuze em Post-scriptum sobre as sociedades de controle, argumentamos que os algoritmos delimitam espaços fluidos controlados em redes de comunicação. Assumindo, em consonância com Deleuze, que o controle está situado não diretamente com o aspecto financeiro, mas age por ele, as sociedades de controle estão baseadas na produtividade (positividade) e em seus efeitos a partir de contextos políticos, suportado por um sistema de consumo de informação. Os algoritmos, por sua vez, têm a capacidade de tomar decisões e mapear categorias, traduzindo uma capacidade de formar, controlar, homogeneizar um sistema de relações subjetivas, transformando-o em um sistema de classificação objetiva. Há, nesse contexto, definição de liberdades e de controles sendo construídos de maneira constante na instauração de um discurso cultural.
Tendências inovadoras da Gestão da Informação e do Conhecimento na produção científica da Ciência da Informação
Authors: Duarte Emeide Nóbrega , Feitoza Rayan Aramís de Brito , Lima Ana Raquel Pereira de
Published: September 2020

Analisa a produção científica sobre Gestão da Informação e do Conhecimento veiculadas aos anais do Grupo de Trabalho 4 do Encontro Nacional de Pesquisa em Ciência da Informação e no periódico Perspectivas em Gestão & Conhecimento nos anos de 2018 e 2019, com o propósito de comparar os resultados e tomar conhecimento sobre as tendências inovadoras do tema estudado. Metodologicamente, quanto à natureza, esta pesquisa caracteriza-se como exploratória, descritiva, de abordagem quantitativa e qualitativa e um estudo do tipo documental realizado no ambiente da web. Para organização dos dados, adota o método de análise de conteúdo. Ao identificar as unidades de contexto e as unidades de registro dos indicadores relevantes nos textos da produção científica analisada e pela comparação entre estes resultados, conclui que as tendências para abordagens inovadoras são focadas no compartilhamento do conhecimento, na aprendizagem organizacional, na cultura organizacional e nos relacionamentos em rede.
Sistema colaborativo no ensino superior público
Authors: Suiter Daniel , Pacheco Andressa Sasaki Vasques
Published: September 2020

Este artigo faz uma proposta de um sistema colaborativo no ensino superior público brasileiro como um modelo ou ferramenta estratégica para alcançar seus objetivos e atender de forma mais efetiva as demandas sociais e mercadológicas. Trata-se de pesquisa de natureza básica, quanto aos fins exploratória, quanto aos meios bibliográfica e documental, justificada pela quantidade de vagas novas ofertadas no Brasil versus vagas ocupadas e interessados. Correlaciona a oferta de vagas no curso de Medicina com a questão da saúde pública brasileira como indicador de uma das demandas sociais e da interferência do estado sobre as IES. Conclui-se que o modelo proposto pode ser implementado do nível estratégico até o operacional, com possibilidade de significativo ganho de eficiência e abrangência.
Phytochemistry, Traditional Uses and Pharmacological Properties of Enhydra fluctuans Lour: a Comprehensive Review
Authors: Barua Antica , Alam Muhammad S. , Junaid Md. , Akter Yeasmin , Afrose Syeda S. , Sharmin Tania , Akter Rasheda , Hosen S.M. Zahid
Published: September 2020

Background:

Enhydra fluctuans Lour, a tropical herb, commonly known as helencha or
harkuch, belongs to the family Asteraceae. It is an edible semi-aquatic herbaceous vegetable plant with
serrate leaves and grows commonly in different parts of the world. Enhydra fluctuans possesses potential
pharmacological role against inflammation, cancer, diarrhea, microbial infection, diabetes, etc.

Aim:

This review aims to provide the most current information on the botanical characterization, distribution,
traditional uses, chemical constituents, as well as the pharmacological activities of Enhydra
fluctuans Lour.

Materials and Methods:

The recently updated information on Enhydra fluctuans was gathered from
scientific journals, books, and worldwide accepted scientific databases via a library and electronic
search PubMed, Elsevier, Google Scholar, Springer, Scopus, Web of Science, Wiley online library. All
of the full-text articles and abstracts related to Enhydra were screened. The most important and relevant
articles were carefully chosen for study in this review.

Results:

Crude extracts and isolated compounds of Enhydra fluctuans Lour have been reported to be
pharmacologically active against cytoprotective, analgesic and anti-inflammatory, antimicrobial, anticancer,
antidiarrheal, antihelmintic, CNS depressant, hepatoprotective, thrombolytic, antidiabetic, antioxidant,
phagocytic and cytotoxic, and neuroprotective potential activities.

Discussion:

Phytochemical analysis from different studies has reported Germacranolide, Sesquiterpene
lactone, Flavonoid, Essential oil, Steroid, Diterpenoid, Melampolide, Sesquiterpene lactone, and Isoflavone
glycoside as major compounds of Enhydra fluctuans Lour.

Conclusions:

However, more research is needed to explore the mode of action of bioactive components
of the plant and its therapeutic capabilities.
Exploring μ-Opioid Receptor Splice Variants as a Specific Molecular Target for New Analgesics
Authors: Mizoguchi Hirokazu , Fujii Hideaki
Published: September 2020

Since a μ-opioid receptor gene containing multiple exons has been identified, the variety of
splice variants for μ-opioid receptors have been reported in various species. Amidino-TAPA and
IBNtxA have been discovered as new analgesics with different pharmacological profiles from morphine.
These new analgesics show a very potent analgesic effect but do not have dependence liability. Interestingly,
these analgesics show the selectivity to the morphine-insensitive μ-opioid receptor splice variants.
The splice variants, sensitive to these new analgesics but insensitive to morphine, may be a better molecular
target to develop the analgesics without side effects.
Substituted 6,7-dimethoxy-5-oxo-2,3,5,9b-tetrahydrothiazolo[2,3-a]isoindole- 3-1,1-dioxide Derivatives with Antimicrobial Activity and Docking Assisted Prediction of the Mechanism of their Antibacterial and Antifungal Properties
Authors: Geronikaki Athina , Kartsev Victor , Eleftheriou Phaedra , Petrou Anthi , Glamočlija Jasmina , Ciric Anna , Soković Marina
Published: September 2020

Background:

Although a great number of the targets of antimicrobial therapy have been
achieved, it remains among the first fields of pharmaceutical research, mainly because of the development
of resistant strains. Docking analysis may be an important tool in the research for the development
of more effective agents against specific drug targets or multi-target agents 1-3.

Methods:

In the present study, based on docking analysis, ten tetrahydrothiazolo[2,3-a]isoindole derivatives
were chosen for the evaluation of the antimicrobial activity.

Results:

All compounds showed antibacterial activity against eight Gram-positive and Gram-negative
bacterial species being, in some cases, more potent than ampicillin and streptomycin against all species.
The most sensitive bacteria appeared to be S. aureus and En. Cloacae, while M. flavus, E. coli and P.
aeruginosa were the most resistant ones. The compounds were also tested for their antifungal activity
against eight fungal species. All compounds exhibited good antifungal activity better than reference
drugs bifonazole (1.4 – 41 folds) and ketoconazole (1.1 – 406 folds) against all fungal species. In order
to elucidate the mechanism of action, docking studies on different antimicrobial targets were performed.

Conclusion:

According to docking analysis, the antifungal activity can be explained by the inhibition of
the CYP51 enzyme for most compounds with a better correlation of the results obtained for the P.v.c.
strain (linear regression between estimated binding Energy and log(1/MIC) with R 2 =0.867 and
p=0.000091 or R 2 = 0.924, p= 0.000036, when compound 3 is excluded.
Advancements in Treatment Options of Women Infertility
Authors: Lorzadeh Nahid , Kazemirad Yasaman , Kazemirad Nastran
Published: September 2020

:

Infertility is defined as inability to conceive pregnancy after one year or more of unprotected sex, among the
women at the risk of conceiving pregnancy. In addition, to age-factor, it is known to be associated with pathological and
genetic conditions that contribute to its early onset. Polycystic ovarian syndrome (PCOS), endometriosis, fibroids and
blockade in fallopian tubes are certain common pathological causes of female infertility. Researches are focused to
eradicate primary cause of infertility in order to achieve healthy fertile ground for fertilization. Depending on the cause,
therapeutic options include, medicines (chemical, herbal and Chinese), hormonal stimulation, surgery, assistive
reproductive technology and tissue engineering. To the extent of research, biotechnology has played significant role to
answer the problem. This review discusses advancements in these therapeutic fields, in order to treat women-associated
infertility.
Atorvastatin Prevents the Neuron Loss in the Hippocampal Dentate Gyrus Region through its Anti-Oxidant and Anti-Apoptotic Activities
Authors: Yadollah-Damavandi Soheila , Sharifi Zahra N. , Arani Hamid Z. , Jangholi Ehsan , Karimi Aliasghar , Parsa Yekta , Movassaghi Shabnam
Published: September 2020

Background:

Atorvastatin is a member of statins, which has shown positive vascular effects,
anti-oxidant, anti-platelet, and anti-apoptotic properties.

Objective:

In this study, we hypothesized that atorvastatin could prevent the neurons lost in the hippocampal
dentate gyrus region after transient global Ischemia/Reperfusion (I/R) through its anti-
oxidant and anti-apoptotic activities.

Method:

Twenty-four male Wistar rats, 12-13 weeks old and weighing 250–300 g, were divided
randomly into four groups: control, I/R, vehicle (I/R treated with NaCl) and experiment (I/R treated
with atorvastatin, 10 mg/kg); rats were sacrificed 96 hours after I/R. Quantitative expression of
genes (caspase 8, p53, bax, bcl2, cytochrome c) was studied. The MDA level, SOD, CAT, and GPx
activities were measured with biochemical tests. To detect apoptotic cells, TUNEL and Nissl staining
were performed. Mitochondria were prepared from the hippocampus rats and used for the quantification
of mitochondrial ROS, ATP level, GSH content, membrane potential, cytochrome c release,
and determination of mitochondrial swelling.

Results:

Atorvastatin attenuated the overexpression of bax, cytochrome C, p53, and caspase8 mRNAs
and induced expression of bcl-2 mRNA (P<0.001). Atorvastatin treatment increased anti-oxidant
enzyme levels (P<0.01). Treatment with atorvastatin reduced the number of TUNEL-positive
cells. It could decrease the cytochrome c release (P<0.01), inhibit the decrease of MMP (P<0.001)
and increase the ATP level (P<0.001) in hippocampal mitochondria compared with the I/R group.

Conclusion:

Atorvastatin treatment in I/R rats decreases oxidative stress, production of ROS, apoptosis
rate in neuronal cells, and improves the mitochondrial function. Hence, atorvastatin has a
proper neuronal protective effect against the I/R injury in the brain.
Rule-based Classifiers for Suspect Detection from CCTV Footages
Authors: Pathak Sunil
Published: September 2020

Background:

A significant work has been presented to identify suspects, gathering
information and examining any videos from the CCTV Footage. This exploration work expects to
recognize suspicious exercises, i.e., object trade, the passage of another individual, peeping into
other's answer sheet and individual trade from the video caught by a reconnaissance camera amid
examinations. This requires the procedure of face acknowledgment, hand acknowledgment and
distinguishing the contact between the face and hands of a similar individual and that among various
people.

Methods:

Segmented frames have been given as input to obtain a foreground image with the help
of Gaussian filtering and background modeling method. Such foreground images have been given
to Activity Recognition model to detect normal activity or suspicious activity.

Result:

Accuracy rate, Precision and Recall are calculated for activities detection, contact detection
for Best Case, Average Case and Worst Case. Simulation results are compared with performance
parameter such as Material Exchange, Position Exchange, and Introduction of a new person,
Face and Hand Detection and Multi Person Scenario.

Conclusion:

In this paper, a framework is prepared for suspect detection. This framework will
absolutely realize an unrest in the field of security observation in the training area.