bluuebunny/crossref_metadata_2025 huggingface dataset:
Displacement compensators for the skylines of timber transportation cableways
Authors: Rudko Ihor , Bakay Borys , Karatnyk Ihor , Gobela Volodymyr , Radiak Ivan
Published: September 2023

Cableways for timber transportation are quite effective in terms of manufacturability, specific energy consumption, material capacity and the negative impact level on the environment in difficult natural operating conditions, compared to similar types of machines. Since non-stationary cableways are usually used in forestry production, which are characterized by a light construction with relatively small safety margins of cable equipment elements, then for this type of roads, the reliability and safety of the skylines work are important factors for their effective operation. In order to reduce the cost and duration of installation and dismantling operations, the skylines are usually rigidly fixed to trees, stumps or artificial supports. Such a cable fastening scheme is technically convenient, but it does not allow for constant tension of the skylines when the carriage with the load is moving along the span, under wind load, possible temperature fluctuations, icing of structural elements, and emergency situations. As a result, intensive changes in cable tension during their operation cause dynamic loads and vibrations in the cable rigging, as well as uneven and accelerated wear of the skylines, and a decrease in their durability. Under such conditions, in order to increase the reliability of the cable rigging of timber transportation cableways (both individual existing models of equipment and the latest ones), it is proposed to equip them with displacement compensators for the skylines. After analyzing a number of prototype devices that are effectively used in related industries, it was concluded that pneumatic, mechanical, and hydraulic compensator designs can be considered rational for timber production. Therefore, in view of the above, we performed a detailed calculation and designed the main technical elements of the compensating device, developed a control scheme for its working body, and analyzed its stress-strain state using the Autodesk Inventor software package. The use of rational compensator designs and appropriate control schemes for their working bodies will create the prerequisites for reliable and safe operation of timber transportation cableways in various operating modes and terrain and climatic conditions, and minimize the likelihood of emergencies
The research of quality indicators of traffic management in the city using the method of GPS-tracks
Authors: Riabushenko Oleksandr , Sklyarov Mikola , Kashkanov Vital
Published: September 2023

The choice of rational quality criteria for the organization of road traffic in cities is an urgent task for scientists in the field of road transport, as it directly affects the effectiveness of activities in the field of ensuring the safety and comfort of car traffic in urban conditions. Depending on the goals of the analysis, the complexity of the network, and technical capabilities, the quality of traffic management can be assessed by indicators of the economic efficiency of the transport process, the level of accidents, environmental safety, social attractiveness, etc. The modern level of development of geo-information technologies allows for constant monitoring of the vehicle's speed mode. To obtain characteristics of the quality of traffic organization, experimental studies were conducted on a section of the street-road network of the city of Kharkiv, which corresponds to a typical route of personal transport from a remote sleeping area to the central part of the city.

As a result of data processing of the GPS track, a histogram of the distribution of instantaneous speed and graphs of the car’s movement in the coordinates “time-distance”, “time-speed”, "distance-speed” were built, which allow you to visually assess the mode of movement along the entire route and determine potential "bottlenecks". Such spatio-temporal characteristics as average technical speed, specific time in motion, specific idle time, as well as energy indicators of the quality of traffic management were also calculated: acceleration noise, speed gradient, energy gradient. After dividing the experimental route into separate kilometer sections, changes in the characteristics of the quality of traffic organization, as it approached the city center, were analyzed. On the first half of the route, when moving along the main street, the instability of the speed regime was observed due to stops and idling in the zone of regulated intersections. The presence of a trend towards a decrease in the average technical speed when approaching the city center is explained by an increase in the loading of VDM within the central business part of the city and, as a result, the appearance of additional traffic delays. As we approached the city center, the specific time in motion increased with a slight increase in the specific idle time, and an increase in the speed gradient was also observed with a slight decrease in the energy gradient.
Improvement of the method for determining the fuel consumption of a vehicle operating on alternative fuel
Authors: Gritsuk Igor , Volkov Volodymyr , Pohorletskyi Dmytro , Kuzhel Volodymyr , Volkova Tetiana
Published: September 2023

The purpose of the conducted research is to improve the method of calculation and determination of both fuel consumption and emissions of harmful substances from the engines of vehicles converted to run on alternative fuel. The article examines the peculiarities of determining fuel consumption and emissions of harmful substances from the engines of vehicles converted to run on alternative fuel. The method of calculating fuel consumption and environmental indicators of vehicles running on alternative fuel has been developed, which is based on a systematic combination of methods and means of obtaining information about the processes and operating conditions of vehicles, which are obtained as a result of remote monitoring of parameters of the technical condition of vehicles. The peculiarity of the method is that it involves the joint use of both existing methods and means of obtaining information on vehicle operation processes, engine thermal parameters, fuel consumption and emissions of harmful substances. This method of calculating both fuel consumption and emissions of harmful substances in the exhaust gases of a vehicle with engines converted to run on gas fuel allows to evaluate the efficiency of the operation of the vehicle engine thanks to the analysis of current and total values of indicators of fuel consumption and emissions of harmful substances in processes pre-launch and post-launch thermal preparation and during its movement in the driving cycle and during movement on the route.

In the work, the authors proposed to use the fuel consumption coefficients for both liquid and gaseous fuels to determine the fuel consumption in operating conditions, which make it possible to abstract from the dimensions. For the vehicle engine cooling system, it is proposed to measure fuel efficiency and other environmental indicators according to existing methods in several modes of heating the coolant up to a temperature of 50°C.
Design design of technical systems
Authors: Zinko Roman , Cherevko Yury , Beshley Andrii , Polyakov Andriy
Published: September 2023

The improvement of the methods of reducing dynamic loads in the elements of self-propelled transport machines and transported goods is based on the results of the analysis of dynamic phenomena that occur during their operation, which is due to the growth of load, increase of working speeds, combination of loading and unloading operations with other technological operations, increase in productivity.

To prevent damage and ensure traffic safety, packaging and artificial cargoes are secured in car bodies, train carriages and ship holds with wire ties, thrust and spacer bars, tying and other methods.

But during transportation, as a result of stretching and breaking of stretch marks and pulling out of nails, goods are damaged, moving in a body, wagon or hold. Therefore, it is very important at the design stage of the fastening structure to establish the possible movement of the load, as well as to ensure it within the given limits in order to prevent damage to the load.

The authors proposed a method of calculating load fluctuations in the body of a truck using the example of two loads of different weights. A kinematic diagram of a self-propelled transport machine with sequential elastic coupling of transported loads was built and a study of nonlinear horizontal oscillations of a loosely secured load during the movement of the vehicle was carried out.

According to the results of the research, graphs of the dependences of the dimensionless amplitude of the weight of the load relative to other loads depending on the gap between the fasteners were constructed. Maps of regions of stable movements are constructed and the region of unstable movements of loads is shown. It is noted that although such an area of unstable movements is quite small, but under certain conditions of movement of the vehicle and weakly secured cargo, phenomena can occur that can cause a traffic accident.
Quand le personnel de vente en front-office perturbe le traitement des réclamations
Authors: Reniou Fanny , Subramanian Dilip
Published: September 2023

S'appuyant sur une étude qualitative avec des employés de banque, et à travers l'éclairage de la théorie des rôles, cette recherche identifie des rôles déviants du personnel de vente en front-office (PVFO) dans la gestion des réclamations : la rétention, la dénégation-relégation et la désimplication. Ces rôles constituent des stratégies d'ajustement pour gérer des tensions personnelles et sont la manifestation d'un pouvoir d'agir face aux équipes et au client. La recherche, à la frontière du marketing et des ressources humaines, propose des recommandations managériales visant à limiter les rôles déviants du PVFO qui nuit au travail des autres personnels.
The Regulation of Pyroptosis and Ferroptosis by MicroRNAs in Cardiovascular Diseases
Authors: Faramarzzadeh Reza , Shariati Akram , Shahabi Raberi Venous , Masumi Mehdi , Tarbiat Ali , Rastgoo Elham
Published: September 2023

Cardiovascular diseases (CVDs) are considered the most prevalent noncommunicable disease and the leading cause of death worldwide. A plethora of evidence has revealed that microRNAs (miRNAs) could control the inhibition or progression of CVDs by regulating pivotal cell processes ranging from metabolism and homeostasis to programmed cell death (PCD). Pyroptosis and ferroptosis are two major types of nonapoptotic PCDs involved in the pathogenesis of heart failure. However, no study has discussed the crosstalk between miRNAs and these two types of PCDs in the CVDs. The current review demonstrated that different types of miRNAs can regulate both ferroptosis and pyroptosis and thereby affect CVDs progression and inhibition. Altogether, the discussed content encourages further studies to confirm that mentioned pathways are suitable to be considered as novel therapeutic approaches against CVDs.
Leveraging Artificial Intelligence for Advancements in the Pharmaceutical Field: A Comprehensive Review
Authors: Ahmed Amira
Published: September 2023

The pharmaceutical industry has witnessed a paradigm shift with the integration of artificial intelligence (AI) into various aspects of drug discovery, development, and healthcare delivery. This paper provides a comprehensive review of the impact of AI in the pharmaceutical field, highlighting its contributions, challenges, and prospects. We explore AI applications in drug discovery, clinical trials, personalized medicine, and healthcare management, emphasizing the potential benefits and ethical considerations associated with this transformative technology.
Apiariusz z Sicca Veneria i odwoływanie się do Ojców na synodach Afryki Łacińskiej (IV-VI w.)
Authors: Degórski Bazyli
Published: September 2023

Synody Kościoła łacińskiego Afryki IV-VI w. świadczą, że ich uczestnicy byli przekonani, iż trzeba opierać się na autorytecie poprzedników i odwoływać się do Tradycji. Wyrażenie „ojcowie” (lub rzadkie formy analogiczne, takie jak chociażby „bracia” – ἀδελφοί, fratres) było synonimem „Tradycji”, ponieważ wiązało się ściśle z autorytetem soborów, w szczególności Pierwszego Soboru w Nicei, którego znaczenie dogmatyczne nie ma sobie równego w historii Kościoła. Konsekwencją uznania Pierwszego Soboru Nicejskiego za niepodważalną Tradycję jest nadanie wypowiedziom Ojców charakteru normatywnego obowiązującego nawet Kościół Rzymski. Lektura dokumentów synodów afrykańskich ujawnia coraz wyraźniejsze precyzowanie wyznaczników Tradycji: apostolskiego pochodzenia, starożytności, powszechnej akceptacji. Ale to przede wszystkim uznanie działania Ducha świętego w kolegium synodalnym nadaje Tradycji moc wiążącą i pozwala na utożsamienie jej z wiarą i prawdą. Dokumentacja synodów afrykańskich stanowi decydujący krok w ewolucji relacji między Rzymem a innymi biskupstwami w zakresie prymatu jurysdykcyjnego czy autorytatywnej roli Rzymu. W swoich ostatecznych reperkusjach kwestia ta jest więc zabarwiona tonami eklezjologicznymi i ekumenicznymi. Omawiane teksty, przechodzące od uwarunkowań dyscyplinarnych i egzystencjalnych do centralnego problemu autorytetu w Kościele, pozwalają odkryć ogromny wkład Kościoła afrykańskiego w starożytną myśl chrześcijańską tego złotego wieku, w którym działali tacy Ojcowie, jak Aureliusz, Alipiusz, czy sam Augustyn.
Średniowieczna liryka nabożna (wybór)
Authors: Gacia Tadeusz
Published: September 2023

Przekład na język polski pięciu utworów z Analecta hymnica.
Decreta caelestia versus princeps bonus w świetle "Res Gestae" Ammiana Marcellina
Authors: Bralewski Sławomir
Published: September 2023

Ammian Marcellin w Res Gestae  uczynił z cesarza Juliana wzór dobrego władcy, mimo że bogowie zadecydowali o klęsce jego wyprawy perskiej, w której on sam poniósł śmierć. Dokonując oceny jego charakteru przypisał mu konkretny katalog cnót. Na ich czele znalazły się najpierw cztery cnoty kardynalne: temperantia, prudentia, iustitia i fortitudo, które zostały uzupełnione dodatkowo przez scientia rei militaris, auctoritas, felicitas i liberalitas. Zabrakło wśród nich pietas, należącej w przekonaniu Rzymian do zasadniczych cnót moralnych, która w epoce cesarstwa stała się kardynalną cnotą imperatorów. Kwestia ta nie znalazła dotychczas należytego wyjaśnienia. Analizując przekaz Ammiana Marcellina autor artykułu wykazał, że Ammian Marcellin zrezygnował z pietas, gdyż powszechnie była znana przesada z jaką Julian celebrował kulty tradycyjne. Tym bardziej że tego typu nadużycia generowały oskarżenie o superstitio. Niewątpliwie Ammian był zafascynowany postacią cesarza, widząc w jego postępowaniu wzór do naśladowania dla innych panujących. Zależność felicitas od pietas stanowiła jednak dla niego poważny kłopot, wymagający rozwiązania. Postanowił więc zrezygnować z lansowania pobożności Juliana jako cnoty cesarskiej. Nie chciał wszelako jego klęski tłumaczyć bezbożnością. Znalazł więc wyjaśnienie, które cesarza nie obciążało, a był nim kapryśny charakter Fortuny.
Patrystyczne początki kultu eucharystycznego poza Mszą
Authors: Królikowski Janusz
Published: September 2023

W artykule zostaje podjęte zagadnienie początków kultu eucharystycznego poza Mszą, z wyjątkiem Wiatyku, który należy do stałej tradycji Kościoła. Chodzi o określenie, czy i w jakim zakresie ta problematyka jest obecna w pismach ojców Kościoła oraz w praktyce kościelnej w pierwszym tysiącleciu. Bardzo powoli pojawiają się pewne przejawy kultyczne, które zwracają niewątpliwie uwagę na potrzebę szerokiego widzenia Eucharystii w całości życia chrześcijańskiego, chociaż o właściwym kulcie nie ma wówczas jeszcze mowy. Niemniej jednak można powiedzieć, że liczne kwestie eucharystyczne, w kontekście różnych zjawisk duchowych, domagają się coraz większej uwagi ze strony teologów.
Typologia i topografia wczesnochrześcijańskich baptysteriów. Próba spojrzenia teologiczno-historycznego
Authors: Szczur Piotr
Published: September 2023

W artykule poruszono istotny problem badawczy związany z typologią i topografią wczesnochrześcijańskich baptysteriów. Po wprowadzeniu historycznym i filologicznym omówiono dwa zasadnicze zagadnienia. Pierwszym jest przedstawienie różnych form architektonicznych baptysteriów oraz ich dekoracji. Drugim zaś jest omówienie topografii baptysteriów w kompleksach kościelnych. W konkluzji podkreślono, że w starożytności nie istniał żaden typ budowli, który byłby charakterystyczny dla chrześcijańskich baptysteriów i jednoznacznie wskazywałby na liturgiczne przeznaczenie obiektu. Przy wznoszeniu baptysteriów nie kierowano się też symboliką chrześcijańską, lecz wykorzystywano istniejące wzorce architektoniczne, których przestrzeń mogła być przystosowana do celebrowanych w nich obrzędów. Zwrócono też uwagę, na fakt, że nie istniały ściśle określone zasady lokalizacji baptysteriów w kompleksach kościelnych, gdyż były one wznoszone w różnych powiązaniach z obiektem centralnym, jakim jest kościół. Na chrześcijańskie i liturgiczne przeznaczenie obiektów wskazuje przede wszystkim ich dekoracja o tematyce chrześcijańskiej oraz ich lokalizacja w kompleksach zabudowań kościelnych.
Reguła Eugipiusza o funkcji opata
Authors: Czyżewski Bogdan Stanisław
Published: September 2023

Reguła napisana dla klasztoru w Lucullanum przez Eugipiusza (VI w.), chociaż nie należy do zbyt oryginalnych, posiada jednak pewne elementy, na które warto zwrócić uwagę. Jej autor dokonał kompilacji ośmiu reguł starożytnego Kościoła, najwięcej zaczerpnął z pism monastycznych św. Augustyna i z Reguły Mistrza. W kilku miejscach skraca cytowane przez siebie źródła, mając na uwadze specyfikę klasztoru, którego był opatem. Godne zauważenia są teksty mówiące o opacie, któremu przyznaje, zaraz po Chrystusie, najwyższą godność we wspólnocie. Zwraca też uwagę na spoczywającą na nim odpowiedzialność za braci, zarówno w dziedzinie formowania ich życia duchowego jak i karności, której są poddawani, by osiągnąć doskonałość. Oryginalność Reguły Eugipiusza polega też na „korekcie” niektórych „przywłaszczonych” przez niego tekstów, co stwarza pewną trudność, zwłaszcza w odniesieniu do sosowanej przez niego terminologii odnoszącej się do opata. Nie zawsze jest konsekwentny w posługiwaniu się terminami abbas, praepositus i decanus, co powoduje, że nie w każdym przypadku jesteśmy w stanie dokładnie określić, kogo tak naprawdę miał na myśli Eugipiusz. Być może mamy do czynienia nie z typową regułą zawierającą przepisy odnoszące się do codziennych praktyk mieszkańców klasztoru św. Seweryna, co raczej zbiór przepisów pochodzących z różnych wczesnochrześcijańskich reguł, które miały służyć jako przewodnik dla opata w Lucullanum.
Is there a three-ictic taktovik in the verse of Russian bylinas?
Authors: Petrov Alexander
Published: September 2023

The paper attempts to clarify some theses of the accentual theory of folk versification in relation to bylinas — Russian epic songs. A brief overview of the research tradition from Vostokov to the modern time is presented, the most difficult problems of studying the metrics and rhythm of bylina are explicated. Criteria for selecting material for analysis are formulated. The sample is based on published texts from classical folklore collections of Kirsha Danilov, Gilferding, and Rybnikov — 10,111 lines (41 texts). An extensive audio material collected from a bearer of the folklore tradition is used for the study — 632 lines (36 fragments of bylinas). With the help of audio recordings, the features of epic accentuation, previously not fully reflected in published texts, were revealed. Based on them, a hypothesis was formulated about the alternation of lines with 3 and 4 stresses in the structure of an epic verse. Data extracted from audio recordings were extrapolated to texts whose exact sound is unknown. The most typical rhythmical variations of lines with 3 and 4 stresses are presented based on a complete separate metrical and rhythmical analysis. The results are presented in 15 tables. As far as I could discover, the shares of lines with 3 and 4 stresses are more or less balanced, and together normally make up more than 80 % of an epic text. I suggest that the three-ictic model of the epic verse arose as a result of separating text from melody and is a mere reflection of an artificial literary declamation. In reality, the verse of bylina is a taktovik (an accentual verse with mono-, di-, and trisyllabic inter-ictic interval) with alternation of lines with 3 and 4 stresses, variable anacrusis (the range of variation is normally 0–2 syllables), and dactylic or masculine (less often hyperdactylic) ending, with no rhyme.
Varicela na grávida: imunidade, contacto e infeção – a propósito de um caso clínico
Authors:   USF Aqueduto, ACeS Grande Porto IV, Cruz Catarina Afonso , Rodrigues Anabela Carvalho ,   USF Aqueduto, ACeS Grande Porto IV, Sales Rita ,   ACeS Entre Douro e Vouga I
Published: September 2023

Introdução: A varicela na gravidez é uma patologia pouco frequente em Portugal devido à alta taxa de imunidade da população em idade fértil. Associa-se a risco mais elevado de complicações maternas assim como a morbimortalidade fetal significativa, particularmente quando a infeção ocorre até às 20 semanas de gestação ou no período periparto. Descrição do caso: Mulher de 31 anos, natural da Rússia, grávida, 2G1P, vigiada na Unidade de Saúde Familiar e consulta de obstetrícia. Recorreu à consulta aberta da sua Unidade de Saúde Familiar às 27 semanas de gestação por contacto significativo com caso de varicela. Encontrava-se assintomática e não apresentava alterações ao exame objetivo. Desconhecia história prévia de varicela ou zona e não tinha registo de vacinação contra o vírus varicela zoster. Foi orientada para o serviço de urgência de obstetrícia, onde colheu serologias. Foi confirmada ausência de imunidade para o vírus varicela zoster, pelo que realizou profilaxia com imunoglobulina. Desenvolveu varicela às 29 semanas e dois dias de gestação, não tendo sido registadas complicações maternas associadas à varicela ou detetados sinais ecográficos de síndroma de varicela fetal. A gravidez decorreu sem outras intercorrências e terminou às 41 semanas e dois dias de gestação. O recém-nascido não apresentava alterações sugestivas de síndroma de varicela fetal. Comentários: O caso clínico descrito pretende enfatizar a necessidade do conhecimento do médico de família da abordagem das grávidas com contacto com varicela ou que desenvolvam a doença. Para além disso, tem como objetivo alertar para a importância da avaliação do estado de imunidade em idade fértil para a identificação de mulheres potencialmente não imunes e a sua atempada orientação.
A importância da continuidade de cuidados na patologia psiquiátrica: um relato de caso
Authors:   Centro Hospitalar Universitário de Lisboa Central, Canha Filipa , Pitta Rita ,   USF Jardins da Encarnação, Conde Margarida Esteves Nunes Gil ,   USF Jardins da Encarnação
Published: September 2023

Introdução: Os cuidados de saúde primários (CSP) são responsáveis pela resposta a situações de diagnóstico e tratamento de patologias do foro psiquiátrico bem como a referenciação de determinados casos para nível hospitalar. A Lei da Saúde Mental (Lei nº 36/98) determina os princípios da política de saúde mental e regulamenta o internamento compulsivo de pessoas com doença mental, sendo da responsabilidade do médico de família a identificação dessas situações e a ativação do Mandado de Condução ao Serviço de Urgência. Descrição do caso: O caso refere-se a uma utente do sexo feminino, de 50 anos de idade, com antecedentes psiquiátricos de tentativa de suicídio e seguida em consulta de psiquiatria. Em consulta programada de psiquiatria a utente refere quadro de ansiedade e agitação noturna, tendo sido realizado ajuste terapêutico com reavaliação posterior. Por manter queixas é novamente realizada alteração do plano terapêutico. Posteriormente recorre aos CSP em consulta do dia com a médica de família, onde refere incumprimento terapêutico bem como agravamento sintomático associado a irritabilidade e alucinações auditivas na forma de voz única com instruções para realizar atos de auto e hetero-agressividade; fora encaminhada e avaliada no serviço de urgência, com novo ajuste terapêutico e indicação para antecipação de consulta de psiquiatria para reavaliação do quadro. Em consulta subsequente com a médica de família apura-se ideação suicida, auto e hetero-agressividade associadas a pseudo-alucinações acústico-verbais, tendo sido proposta nova ida a SU, que a utente recusou. Pelo contexto, a médica de família aciona o Mandado de Condução que a utente compreende e aceita. Durante o internamento foi realizado novo plano terapêutico, observando-se remissão da ideação auto e hetero-agressiva e das pseudo-alucinações auditivas, bem como eutimização do humor e redução da anedonia e cognições de cariz depressivo. Comentário: Este caso clínico representa a gestão partilhada de utentes com patologia psiquiátrica entre os CSP e a psiquiatria e ainda a importância da vigilância da resposta terapêutica, reforçando a necessidade de aperfeiçoamento na articulação entre os diversos níveis de cuidados com o objetivo de garantir partilha de informação mais eficaz e a melhor prestação de cuidados aos utentes de foro psiquiátrico.
Chile y el CIADI Inmunidad de jurisdicción relativa a la resolución de controversias en materias de inversión ante el CIADI: análisis crítico de la ejecución del laudo Víctor Pey Casado y Fundación Presidente Allende con República de Chile
Authors: Jara Brito Cristián
Published: September 2023

El siguiente artículo se refiere al caso Víctor Pey Casado y Fundación Presidente Allende con República de Chile, el de mayor duración en el sistema CIADI, y que actualmente se encuentra en fase de ejecución ante la justicia española. Se abordarán, principalmente, los aspectos fácticos y procesales que devinieron en la situación procesal actual, así como la particularidad del exorbitante monto por el cual se busca ejecutar el laudo arbitral contra el Estado de Chile en una jurisdicción foránea.
Preparation of rutin loaded niosome by ethanol injection method
Authors:   Department of Physical Chemistry - Pharmaceutics, Buon Ma Thuot University, Viet Nam, Nguyen Thao Phuong Truong ,   Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Viet Nam, Le Quynh Ngoc ,   Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Viet Nam, Tran Thanh Van ,   Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Viet Nam
Published: September 2023

Rutin has low bioavailability due to its high molecular weight and low solubility. Rutin loaded niosome is a promising solution but according to our knowledge, there is no publication about this study in both internal and international journal. This study is aim to formulate rutin loaded niosome with appropriate parameters. Rutin loaded niosome was prepared by ethanol injection method. Briefly, 45 experiments were carried out by varying the cholesterol:span 20 ratio (mol:mol), mixing temperature (40-50-60 oC), mixing time (30-40-50 minutes). These formulations were characterized in term of morphology (observation by optical microscope) and drug loading efficiency. Microscope images were used to exclude the formulations without niosome. The niosome formulations were than characterized their encapsulation efficiency by UV-Vis method. In this research, niosome was created in 7 formulations having encapsulation efficiency from 5.5% to 15.7%. The selected formulation was prepared with cholesterol:span 20 ratio of 3:7 with the formulation parameters of 40 minutes mixing time and 50 oC mixing temperature.
Hiperplasias e Neoplasias dos Órgãos Linfopoéticos: Diagnóstico e Tratamento Pelas Radiações
Authors: Rebello Emanuel , Fialho Francisco , Machado Osolando S.
Published: September 2023

Este trabalho é apresentado do modo como concorreu ao Prêmio Sul América. A nossa experiência no assunto foi, praticamente, feita no Instituto de Câncer do Serviço Nacional de Câncer e o material científico pertence, quase todo, àquele Instituto. O artigo estuda as hiperplasias e neoplasias dos órgãos linfoides, aplicando-se ao diagnóstico e tratamento pelas radiações.
Da Conservação do Nervo Facial nas Parotidectomias
Authors: Burnier Egberto Moreira Penido
Published: September 2023

A parotidectomia total é frequentemente acompanhada de secção do nervo facial. A conservação do nervo da mímica da face é incompatível com uma cirurgia radical da glândula, bastando para tanto que recordemos o trajeto do nervo facial desde sua origem aparente no bulbo atá suas terminações. Depois de um curto trajeto para baixo, penetra na parótida e na sua intimidade divide-se em dois ramos: o cérvico e o têmporo-facial. Só depois dêstes troncos, ditos primários, é que vem a subdivisão dos nervos para os diversos músculos da face, divisão esta que ainda se faz na intimidade do parênquima da glândula. Por este mesmo motivo vamos verificar quão difícil se torna a dissecção do nervo facial do centro para a periferia, e quão difícil é, se não impossível, a retirada total da gândula sem ferir o referido nervo.
Quimioterapia do Câncer
Authors: Azevedo Sérgio de Barros
Published: September 2023

Relatório apresentado em Painel, como Tema Oficial, por ocasião do VI Congresso Internacional de Câncer, realizado em São Paulo, em 28 de julho de 1954.
Tratamento Cirúrgico dos Tumores da Bexiga
Authors: Viana João B.
Published: September 2023

Trabalho apresentado ao VI Congresso Internacional de Câncer realizado em São Paulo, Brasil em 1954.
Traçado Eletroforético nos Casos de Linfoma
Authors: Rebello Emmanuel
Published: September 2023

Trabalho apresentado no VI Congresso Internacional de Câncer – São Paulo, Brasil.
Tumores Encefálicos Experimentais no Rato de Laboratório Após o Implante de Cristais de Metil-Colantreno na Córtex Parietal (Contribuição ao Estudo da Carcinogênese Experimental)
Authors: Pinto Feliciano
Published: September 2023

Trabalho realizado na secção de neurocirurgia do Instituto de Câncer no Rio de Janeiro — Brasil. Apresentado ao VI Congresso Internacional de Câncer realizado entre 22-29 de julho de 1964, em São Paulo, Brasil.
Diagnóstico Diferencial das Lesões da Bôca: Parte I: Lesões Não Blastomatosas.
Authors: Bellizzi Ataliba Macieira
Published: September 2023

O autor apresenta inicialmente a sintomatologia geral, assim como os recursos usuais para o diagnóstico das lesões bucais, acentuando a necessidade do exame direto, minucioso e sistemático, tendo em vista a finalidade, principalmente profilática a que o mesmo se presta.
Orientação Diagnóstica e Terapêutica nos Linfomas e Leucemias
Authors: Vieira Antonio Pinto , Rebello Emmanuel , Abbud Jacyr Antonio
Published: September 2023

Os autores designam como linfoma as seguintes afecções: Bryll Symmers (linfoma macrofolicular), doença de Hodgkin, retículo-sarcoma e linfosarcoma. Apresentam classificações para os linfomas e leucemias. Para o diagnóstico, além dos meios semióticos clássicos, são analisados os exames subsidiários: anatomia patológica, exames hematológicos e exame radiológico. De todos os elementos diagnósticos apresentados, são estudados com mais detalhe, a eletroforese e o mielograma, por constituirem assunto de grande atualidade. Os vários achados de mielogramas para os linfomas e leucemias, são descritos. O traçado eletroforético é estudado com detalhe. Neste trabalho são apresentados dois tipos de aparelhos: a) Kern LK 30, tipo Tiselius que determinado a eletroforese em mínimas quantidades de sôro; b) tipo Wieland Fischer, cuja migração faz-se no papel de filtro. Apresentam ainda resultados eletroforéticos nos diversos tipos de linfomas e leucemias. Os autores apresentam quadro próprio, no qual dividem o tratamento em 4 grupos distintos, que são: — Tratamento pelas irradiações. Il Tratamento quimioterapico. III — Tratamento cirúrgico. IV — Tratamento auxiliar. Ao relatarem com minúcia o tratamento pelas irradiações, além de tecerem considerações sôbre a terapêutica com os isótopos radioativos, analisam as várias técnicas roentgenterápicas, assim como, suas indicações no tratamento destas afecções. O tratamento quimioterápico é dividido em 4 grupos: substâncias radiomiméticas, substâncias citotóxicas, substâncias anti-metabólicas e hormônios. Neste capítulo são analisadas e relatadas as doses das principais drogas usadas no combate a estas enfermidades. Como tratamento auxiliar, os autores, apresentam considerações e emitem suas experiências sôbre: exo sanguíneo transfusão, transfusão e antibióticos. O prognóstico é apresentado com detalhe. Os autores citam casos de leucemia granulocítica crônica, linfosarcoma, retículo-sarcoma e doença de Hodgkin com sobrevida além de 5 anos após tratamento pelos Raios X e pela quimioterapia. O trabalho é ilustrado com farta documentação, constando de fotografias de doentes, fotografias de estruturas microscópicas, quadros esquemáticos e apresentação de radiografias.
Toracotomia Exploradora (Experiência em 75 Casos)
Authors: Burnier Egberto Moreira Penido
Published: September 2023

Trabalho apresentado à Sociedade Brasileira de Cancerologia em 3 de Novembro de 1955, sobre Toracotomia exploradora e a experiência em 75 casos, computados de março de 1952.
Diagnóstico Diferencial das Lesões da Bôca: Parte II: Lesões Não Blastomatosas
Authors: Bellizzi Ataliba Macieira
Published: September 2023

O autor nesse trabalho, apresenta inicialmente a sintomatologia geral assim como, os recursos usuais para o diagnóstico das lesões bucais. Acentua a necessidade do exame direto, minucioso e sistemático, tendo em vista a finalidade principalmente profilática a que o exame se presta. Considerando que a cavidade bucal é a que melhor se presta ao exame direto, apoia-se na mesma para a seqüência dos exames complementares a serem procedidos. Reune as lesões bucais em dois grupos sob o ponto de vista clínico (blastomatosas e não blastomatosas), estudando nesse trabalho o segundo grupo. Exclue a designação pré-cancerosa por motivos expostos. Baseia-se em dados histopatológicos, clínicos, e embriológicos para a classificação. Como a intenção do autor é de traçar orientação clínica para o diagnóstico, as características radiológicas e laboratoriais são vistas superficialmente, procurando sistematizar clinicamente cada grupo e estudando os caracteres particulares das mais frequentes.
Student Engagement
Authors: Dangeni -
Published: September 2023

Increasing numbers of international students bring their different cultures, languages, and educational backgrounds to higher education, and they expect their experiences and interactions with higher education institutions to be rewarding journeys. A key issue - the dynamic and multifaceted concept of student engagement as an important indicator of the quality of the student experience - has yet to be thoroughly addressed in conceptual discussions and empirical studies with international students, and thus deserves more attention. This paper aims to conceptualise this buzzword, i.e., 'student engagement', in higher education, by embracing the complexity and diversity of international students' experiences to enable a deeper understanding of international students' experiences and needs, and to inform research and practice that considers all stakeholders through questions and suggestions.
Vamos brincar? seguros! aperfeiçoando processos de avaliação de segurança de produtos infantis com foco na infraestrutura da qualidade por meio do design
Authors: Correia Walter Franklin Marques , Epsztejn Ruth , Oliveira Rodrigo Alves , Queiroz Júlia Carla de , Murad Karine
Published: September 2023

O ato de brincar é algo tão inerente à condição humana de ser, em suas fases iniciais, quanto o ato de aprender a andar. Diversos produtos infantis são lançados a cada ano no mercado a uma grande velocidade, e diante de tamanha rapidez, pode-se deixar à margem da atenção questões de segurança, que muitas vezes não passariam se fossem mais bem analisadas ou fiscalizadas e ensaiadas. Dentro desta perspectiva, este estudo de caso visa auxiliar no processo de redução de riscos em produtos infantis, levando-se em consideração dentre outros, a Portaria INMETRO/ME – n 302 de 12/07/2021, que apresenta os requisitos de avaliação de conformidade para brinquedos.
Distrofia miotônica associada com taquicardia ventricular sustentada
Authors: Soares Winder Marconsini , Campos Cristiana da Silva
Published: September 2023

A Distrofia Miotônica do tipo I (DM), chamada de doença de Steinert, é a forma mais frequente de distrofia muscular no adulto, com prevalência estimada entre 1:8000 (JORGE et al, 2012). É transmitida por herança autossômica dominante, por alteração do gene da Proteína Quinase da Distrofia Miotônica (DMPK), do cromossomo 19q13.3. Os principais sintomas são fenômenos, miotônicos, distúrbios do ritmo e da condução cardíaca, catarata, endocrinopatias, comprometimento cognitivo, dentre outros (DARRAS et al., 2022).
Residential Electricity Consumption Patterns and their Relationship to Commute Times by Mode
Authors: Acosta-Sequeda Juan , Palani Hevar , Movahedi Ali , Karatas Aslihan , Derrible Sybil
Published: September 2023

In this study, the correlation between emerging electricity consumption patterns in the Chicago area and commute times to work by mode are explored. We found that when aggregating similar daily electricity consumption curves, areas sharing similar electricity patterns are geographically closer to each other and located in regions that are strictly urban or suburban. Furthermore, we modelled these clusters in terms of commute times to work by mode. The findings suggest that morning electricity consumption differs significantly among clusters and that it is caused primarily by long duration public transport trips.
Estrategias terapéuticascon RNA de interferenciapara enfermedades hepáticas
Authors:   Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México, López-de la Mora David ,   Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, México., Sánchez-Roque Cibeles ,   Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México,   Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, México.
Published: September 2023

Las enfermedades hepáticas son un problema de gran impacto económico y social, pues son enfermedades crónicas que tienen consecuencias graves, algunas irreversibles; pudiendo llegar a limitar el desempeño laboral. Las enfermedades del hígado constituyen una de las primeras causas de muerte en muchos de los países desarrollados. La etiología del daño hepático es muy variada, pudiendo ser viral (virus de la hepatitis C o B), por consumo excesivo de alcohol, ingesta crónica de fármacos hepatoxoticos, enfermedades metabolicas, etc. El tratamiento para la enfermedad hepática es limitado y generalmente poco efectivo, por lo que existe una búsqueda constante de nuevas terapias. Una de las nuevas propuestas terapéuticas es el RNA de interferencia (iRNA) que ha demostrado un enorme potencial, en el estudio de mecanismos celulares que se fundamentan en la pérdida de función de un gen. En el caso de las enfermedades hepáticas, el empleo del RNA de interferencia se ha enfocado a suprimir funciones fibrogénicas, inflamatorias o inhibir la replicación viral en el caso del virus de hepatitis C o B. Estas estrategias terapéuticas han sido exitosas en cultivos celulares o modelos animales como validación de la prueba de concepto, por lo que en la próxima década se esperan aplicaciones clínicas de los RNAs de interferencia sobre todo en el área de enfermedades crónico-degenerativas e infecciones virales.
Comunidades de Práctica: Una estrategia para Salud Pública
Authors:   Departamento de Salud Pública, Centro Universitario De Ciencias de la Salud, Rizo-Curiel Genoveva ,   Departamento de Salud Poblacional, Centro Universitario de Tonalá. Universidad de Guadalajara, Salas-Salazar Laura ,   Departamento de Salud Pública, Centro Universitario De Ciencias de la Salud,   Departamento de Salud Poblacional, Centro Universitario de Tonalá. Universidad de Guadalajara, Lozano-Kasten Felipe ,   Departamento de Salud Pública, Centro Universitario De Ciencias de la Salud,   Departamento de Salud Poblacional, Centro Universitario de Tonalá. Universidad de Guadalajara, Vargas-Rodríguez Brenda ,   Departamento de Salud Pública, Centro Universitario De Ciencias de la Salud,   Departamento de Salud Poblacional, Centro Universitario de Tonalá. Universidad de Guadalajara
Published: September 2023

El presente documento, pretende ser una herramienta útil para crear comunidades de Prácticas (CP) en el campo de la Salud Pública. Para crear conocimientos que contribuyan a la formación y crecimiento de una actividad colectiva desarrollada en el marco de un grupo de sociedad civil, académicos y tomadores de decisiones, que generalmente comparten un mismo compromiso, orientado a proteger y mejorar colectiva-mente la salud y el bienestar de la población cuando está sana, restaurar y restablecer su salud cuando esta se pierde y, en caso de presentarse el caso, rehabilitar y reinsertar al enfermo, integrándolo de nuevo a su medio social, laboral y cultural; aprendizaje social que es el fundamento principal de la salud pública.
Mecanismos de autofagia asociados a la efectividad terapéutica contra el cáncer de mama
Authors:   Universidad de Guadalajara LAMAR, Campus Vallarta, Valdez-Pardo María ,   Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, México, López-de la Mora David
Published: September 2023

Este proyecto surgió de la necesidad de saber cómo el mecanismo de autofagia que es indispensable para nuestro cuerpo, es también un factor de riesgo para el cáncer de mama y posteriormente su metástasis. Uno de los principales problemas de en esta investigación es la incidencia de esta enfermedad. El mecanismo de la autofagia es un proceso natural y necesario para la célula se libere de toxinas que incluso puedan provocar cáncer, pero por otro lado tiene una estrecha relación con la génesis del cáncer y al estar avanzado, el impacto que tiene con la metástasis, ya que los medicamentos que se suministren al tratarlo, el proceso de autofagia se encargará de desecharlos y de ésta manera incrementando el daño. Para ello nuestro tratamiento sugiere administrar los fármacos que aprovechen el mecanismo y se pueda disminuir el índice de mortalidad, al inhibir el factor mTOR (activación de akt) se va a encargar de iniciar la actividad de la autofagia (aumenta la resistencia al tamoxifeno en cáncer de mama) que por medio de la Rapamicina combinada con otro medicamento anticancerígeno como es el Tamoxifeno se podrá aumentar su efectividad del medicamento, con ello evitar la metástasis y sus complicaciones. Han surgido grandes avances con respecto a la autofagia y su relación con el cáncer pero existen aún muchas cuestiones por responder. Estas respuestas permitirán manipular los complejos procesos de la autofagia para obtener nuevas terapias para importantes enfermedades y su tratamiento.
Necrosis epidérmica tóxica.Reporte de caso
Authors:   División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Cárdenas-Membrila Ricardo , Rodríguez-Sahagún Martha ,   División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Fierro-Díaz María ,   División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Tapia-Rico Luis ,   División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Guzmán-Díaz Cintia ,   División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Cambero-Pérez Anna ,   División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara
Published: September 2023

La necrosis epidérmica toxica es una reacción cutá-nea adversa de tipo inmunológico secundaria en la mayor parte de los casos reportados a la administra-ción de algún fármaco; se distingue principalmente por el desprendimiento de la piel. La mortalidad de dicha enfermedad oscila entre el 30% al 50% de los casos; actualmente no existe un tratamiento específi-co, pero con la aplicación de ciclosporina se ha visto una disminución significativa en la mortalidad. Con esta revisión de caso se pretende describir la enfermedad de manera general y revisar sus principales signos y síntomas, para llevar a cabo de manera oportuna su diagnóstico ya que la tasa de mortalidad es elevada para la misma, así como para prevenir la aparición de secuelas y obtener un resultado favora-ble como en el caso que a continuación se presenta.
Towards a unified framework for studying behavioural tolerance to anthropogenic disturbance
Authors: Čapkun-Huot Catherine , Blumstein Daniel , Garant Dany , Sol Daniel , Réale Denis
Published: September 2023

Animals vary in how much they respond to risk and the extent to which they can modify their responsiveness over time. How and why animals vary has important consequences for understanding demographic and evolutionary responses to novel or rapidly changing environments. Behavioural tolerance is seen when animals do not have any or have a limited behavioural reaction to a potentially risky situation. Tolerance can emerge from genetic, epigenetic or learning mechanisms, and is mediated by the environment. These mechanisms can influence the speed of acquisition, reversibility, specificity, and duration of the resulting tolerance. Mechanistic clarity is therefore essential to predict the eco-evolutionary consequences of tolerance and to understand and manage human-wildlife interactions in the Anthropocene era.
Novel Clustering Techniques in Wireless Sensor Networks – A Survey
Authors: Swetha Priya T.C. , Sridevi R.
Published: September 2023

A study of Wireless Sensor Networks has been growing tremendously these days. Wireless Sensor Networks play a major role in various fields ranging from smart homes to health care. WSN’s operate independently in remote places. Because of tiny size of the nodes in such type of networks, they have a limited number of resources in terms of energy and power. Basically, sensor networks can be classified into flat and cluster based Wireless Sensor Networks. But, Clustering based Sensor Networks play a major role in reducing the energy consumption in Wireless Sensor Networks. Clustering also focuses on solving the No.s that arise during transmission of data. Clustering will group nodes into clusters and elects Cluster Heads for all clusters in the network. Then the nodes sense data and send that data to cluster head where the aggregation of data will take place. This paper focuses on various novel clustering techniques that improve the network’s lifetime.