bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacts of Reduced Nitrate Supply on Nitrogen Metabolism, Photosynthetic Light-Use Efficiency, and Nutritional Values of Edible Mesembryanthemum crystallinum
Authors: He Jie , Qin Lin
Published: June 2021

Mesembryanthemum crystallinum (common ice plant), as a nutritious ready-to-eat salad in Singapore, has become popular in recent years. However, basic data about the impacts of NO3– supply on its NO3– accumulation and nutritional quality are lacking. In this study, all plants were first grown indoor hydroponically in 10% artificial seawater (ASW) with modified full-strength Netherlands Standard Composition nutrient solution for 11 days, before transferring them to different reduced NO3– solutions. All plants grew well and healthy after 7 days of treatment. However, plants grown with 3/4 N and 1/2 N were bigger with higher shoot and root fresh weight (FW), greater leaf number, and total leaf area (TLA) than those grown with full nitrogen (N), 1/4 N, and 0 N. Mesembryanthemum crystallinum grown with full N, 3/4 N, and 1/4 N had similar specific leaf area (SLA), while 0 N plants had significantly lower SLA. All plants had similar leaf succulence (LS). However, leaf water content (LWC) was lower, while leaf dry matter accumulation (LDMC) was higher in 0 N plants after 7 days of treatment. Compared with plants grown with full N, shoot NO3– concentrations in 3/4 N, 1/2 N, and 1/4 N plants were constant or slightly increased during the treatments. For 0 N plants, shoot NO3– concentration decreased significantly during the treatment compared with other plants. Shoot NO3– accumulation was associated with nitrate reductase activity (NRA). For instance, after 7 days of treatment, shoot NO3– concentration and NRA on a FW basis in 0 N plants were, respectively, 45 and 31% of full N plants. After transferring full N to 0 N for 7 days, all M. crystallinum had higher chlorophyll (Chl) content coupled with higher electron transport rate (ETR) and higher effective quantum yield of PSII, while full N plants had higher non-photochemical quenching (NPQ). The 0N plants had much higher concentrations of proline, total soluble sugar (TSS), and total ascorbic acid (ASC) than other plants. In conclusion, totally withdrawing NO3– from the growth media prior to harvest could be one of the strategies to reduce shoot NO3– concentration. Reduced NO3– supply further enhanced nutritional values as concentrations of proline, TSS, and ASC were enhanced markedly in M. crystallinum plants after transferring them from full N to 0 N.
Effectors of Plant Necrotrophic Fungi
Authors: Shao Dandan , Smith Damon L. , Kabbage Mehdi , Roth Mitchell G.
Published: June 2021

Plant diseases caused by necrotrophic fungal pathogens result in large economic losses in field crop production worldwide. Effectors are important players of plant-pathogen interaction and deployed by pathogens to facilitate plant colonization and nutrient acquisition. Compared to biotrophic and hemibiotrophic fungal pathogens, effector biology is poorly understood for necrotrophic fungal pathogens. Recent bioinformatics advances have accelerated the prediction and discovery of effectors from necrotrophic fungi, and their functional context is currently being clarified. In this review we examine effectors utilized by necrotrophic fungi and hemibiotrophic fungi in the latter stages of disease development, including plant cell death manipulation. We define “effectors” as secreted proteins and other molecules that affect plant physiology in ways that contribute to disease establishment and progression. Studying and understanding the mechanisms of necrotrophic effectors is critical for identifying avenues of genetic intervention that could lead to improved resistance to these pathogens in plants.
Developmental Stage-Specific Effects of Parenting on Adolescents’ Emotion Regulation: A Longitudinal Study From Infancy to Late Adolescence
Authors: Tammilehto Jaakko , Punamäki Raija-Leena , Flykt Marjo , Vänskä Mervi , Heikkilä Lotta M. , Lipsanen Jari , Poikkeus Piia , Tiitinen Aila , Lindblom Jallu
Published: June 2021

The quality of parenting shapes the development of children’s emotion regulation. However, the relative importance of parenting in different developmental stages, indicative of sensitive periods, has rarely been studied. Therefore, we formulated four hypothetical developmental timing models to test the stage-specific effects of mothering and fathering in terms of parental autonomy and intimacy in infancy, middle childhood, and late adolescence on adolescents’ emotion regulation. The emotion regulation included reappraisal, suppression, and rumination. We hypothesized that both mothering and fathering in each developmental stage contribute unique effects to adolescents’ emotion regulation patterns. The participants were 885 families followed from pregnancy to late adolescence. This preregistered study used data at the children’s ages of 1 year, 7 to 8 years, and 18 years. At each measurement point, maternal and paternal autonomy and intimacy were assessed with self- and partner reports using the Subjective Family Picture Test. At the age of 18 years, adolescents’ reappraisal and suppression were assessed using the Emotion Regulation Questionnaire and rumination using the Cognitive Emotion Regulation Questionnaire. Stage-specific effects were tested comparing structural equation models. Against our hypotheses, the results showed no effects of mothering or fathering in infancy, middle childhood, or late adolescence on adolescents’ emotion regulation patterns. The results were consistent irrespective of both the reporter (i.e., self or partner) and the parental dimension (i.e., autonomy or intimacy). In addition to our main results, there were relatively low agreement between the parents in each other’s parenting and descriptive discontinuity of parenting across time (i.e., configural measurement invariance). Overall, we found no support for the stage-specific effects of parent-reported parenting in infancy, middle childhood, or late adolescence on adolescents’ emotion regulation. Instead, our findings might reflect the high developmental plasticity of emotion regulation from infancy to late adolescence.
The Mediating Roles of Core Self-Evaluation and Career Exploration in the Association Between Proactive Personality and Job Search Clarity
Authors: Zhu Hongrui , Zhang Hua , Tu Aixian , Zhang Siqi
Published: June 2021

In recent years, university students’ employment has become an increasingly prominent problem worldwide. Improving the job search clarity of students is a great way to boost job-hunting success. Proactive personality may predict job search clarity through the mediating effects of core self-evaluation and career exploration. However, few studies have explored this relationship and the mediating roles of core self-evaluation and career exploration. To identify the relationship between a proactive personality and job search clarity and the mediating roles of core self-evaluation and career exploration, a cross-sectional survey was conducted. A total of 495 students majoring in nursing completed the questionnaire which consisted of the proactive personality scale, core self-evaluation scale, career exploration survey, and job search clarity scale. Correlation analyses and mediation analyses were conducted using SPSS 24.0 and AMOS 24.0 respectively. This study showed that students higher on the proactive personality scale were more likely to perform better on job search clarity. Core self-evaluation and career exploration have fully mediating effects on the relationship between a proactive personality and job search clarity. Therefore, interventions concentrated on cultivating proactive personality, improving core self-evaluation, and strengthening career exploration would be necessary for increasing job search clarity.
Love Forgiveness and Subjective Well-Being in Chinese College Students: The Mediating Role of Interpersonal Relationships
Authors: Cheng Tianyi , Lin Qiyi , Fu Hong
Published: June 2021

Love forgiveness is categorized as forgiveness in a specific relationship, which is the tendency of individuals to forgive the objects of their interpersonal relationships. We investigated 831 undergraduate students in China with a love forgiveness questionnaire, a subjective well-being questionnaire and an interpersonal relationship comprehensive diagnostic, including demographic variables. Students of different genders and grades showed significant differences across the three questionnaires. There were significant correlations between love forgiveness, interpersonal relationships, and subjective well-being of Chinese college students. Interpersonal relationships played an intermediary role between love forgiveness and subjective well-being of Chinese college students. Specifically, whereas Chinese college students’ love forgiveness could directly promote the improvement of subjective well-being, love forgiveness could also indirectly improve subjective well-being through interpersonal relationships. The mediating effect of interpersonal relationships between love forgiveness and subjective well-being accounted for 40.52% of the total effect. This provides a new way of thinking for psychological counselors to approach the intimate relationship problems of college students.
Unrealistic Optimism and Risk for COVID-19 Disease
Authors: Gassen Jeffrey , Nowak Tomasz J. , Henderson Alexandria D. , Weaver Sally P. , Baker Erich J. , Muehlenbein Michael P.
Published: June 2021

Risk perception and consequently engagement in behaviors to avoid illness often do not match actual risk of infection, morbidity, and mortality. Unrealistic optimism occurs when individuals falsely believe that their personal outcomes will be more favorable than others' in the same risk category. Natural selection could favor overconfidence if its benefits, such as psychological resilience, outweigh its costs. However, just because optimism biases may have offered fitness advantages in our evolutionary past does not mean that they are always optimal. The current project examined relationships among personal risk for severe COVID-19, risk perceptions, and preventative behaviors. We predicted that those with higher risk of severe COVID-19 would exhibit unrealistic optimism and behave in ways inconsistent with their elevated risk of morbidity and mortality. Clinical risk scores for severe COVID-19 were calculated and compared with COVID-19 threat appraisal, compliance with shelter-in-place orders (March 13–May 22, 2020) and travel restrictions, compliance with public health recommendations, and potential covariates like self-rated knowledge about COVID-19 in a robust dataset including 492 participants from McLennan County, TX, USA. While those with high clinical risk acknowledged their greater likelihood of experiencing severe illness if infected, they actually reported lower perceived likelihood of becoming infected in the first place. While it is possible that those with higher clinical risk scores truly are less likely to become infected, the pattern and significance of these results held after controlling for possible occupational exposure, household size, and other factors related to infection probability. Higher clinical risk also predicted more recent travel within Texas and lower distress during the pandemic (i.e., feeling less stressed, depressed, and helpless). Additional behavioral data suggested that those with higher clinical risk scores did not generally behave differently than those with lower scores during the shelter-in-place order. While unrealistic optimism may provide some short-term psychological benefits, it could be dangerous due to improper assessment of hazardous situations; inferring that optimism bias has evolutionary origins does not mean that unrealistic optimism is “optimal” in every situation. This may be especially true when individuals face novel sources (or scales) of risk, such as a global pandemic.
Language and the Moving Body: Directive Actions With the Finnish kato “look” in Nature-Related Activities
Authors: Siitonen Pauliina , Rauniomaa Mirka , Keisanen Tiina
Published: June 2021

The article explores how social interaction is accomplished through intertwined verbal and bodily conduct, focusing on directive actions that include a second-person imperative form of the Finnish verbkatsoa“to look,” typicallykato. The study draws on video recordings of various outdoor activities in nature, mostly from family interaction with small children, and employs interactional linguistics and conversation analysis as its analytic framework. The directivekatoactions in focus are produced (1) as noticings, to initiate a new course of action by directing the recipient to look at and possibly talk about a target that the speaker treats as newsworthy; (2) as showings, to initiate an evaluative course of action by directing the recipient to look at and align with the speaker’s stance toward the target; or (3) as prompts, to contribute to an ongoing course of action by directing the recipient to do something relevant to or with the target. Apart from the use ofkato, the actions differ in their design. In noticings, the target is typically named verbally and pointed at through embodied means, but the participants remain at some distance from it (e.g.,kato muurahaispesä tuossa“look an anthill there”). In showings, the participant producing the action typically approaches the recipient with the target in hand, so that the naming of the target is not necessary but, by evaluating the target themselves, the shower explicates how the target should be seen (e.g.,kato kuinka jättejä“look how giant {ones}”). In prompts, neither the target nor the intended action is named, but the target is typically indicated by embodied means, for example, by the participants’ approaching and pointing at it, and the intended action is inferable from the participants’ prior conduct (e.g.,kato tuossa“look there” and pointing at a berry in the participants’ vicinity when berry picking has been established as relevant). By examining these three grammar-body assemblages, the article uncovers regularities in the co-occurrence of multiple modalities and contributes to new understandings of language use in its natural ecology – in co-present social interaction.
Paternal Leave and Father-Infant Bonding: Findings From the Population-Based Cohort Study DREAM
Authors: Schaber Ronja , Kopp Marie , Zähringer Anna , Mack Judith T. , Kress Victoria , Garthus-Niegel Susan
Published: June 2021

Background: Father-infant bonding is important for child development. Yet, in contrast to mother-infant bonding, little is known about factors that might facilitate father-infant bonding. With new generations of fathers being more involved in childcare, this study aims to examine the impact of paternal leave duration on father-infant bonding, and whether this relation is mediated by the amount of time fathers actively spend on childcare.

Methods: Data of n = 637 fathers were derived from the German population-based cohort study “Dresden Study on Parenting, Work, and Mental Health” (DREAM). Mediation analyses were conducted. Duration of paternal leave (predictor), weekly hours spent on childcare (mediator), and father-infant bonding (outcome) were measured at 14 months postpartum. The potential confounders current status of paternal leave, part-time work during paternal leave, duration of solo paternal leave, age, education, and partnership satisfaction were included in a second mediation analysis.

Results: Without considering confounders, duration of paternal leave positively predicted father-infant bonding through weekly hours spent on childcare. When adding confounders to the model, this indirect path did not stay significant. Moreover, in the adjusted model and on the direct path duration of paternal leave negatively predicted father-infant bonding. Additionally, partnership satisfaction positively predicted father-infant bonding. Some study variables were significantly associated with the mediator. Longer duration of paternal leave, currently being on paternal leave, younger age, and lower educational level predicted more weekly hours spent on childcare.

Conclusions: Duration of paternal leave not being a stable predictor for father-infant bonding suggests that fathers, who do not have the opportunity to take long periods of paternal leave, can still form strong bonds with their infants. Other factors, for example partnership satisfaction, which might represent fathers' underlying capacity to bond, might be more crucial for father-infant bonding. At the same time, results should not be interpreted in a way that father involvement (e.g., paternal leave/time spent) does not matter for children's development. The finding that longer duration of paternal leave increases weekly hours spent on childcare supports the idea that facilitating father involvement can be achieved by paternal leave incentives such as non-transferable father months.
Modeling the Keys to Team’s Success in the Women’s Chinese Basketball Association
Authors: Yi Qing , Zhang Shaoliang , Fang Wenxuan , Gómez-Ruano Miguel-Ángel
Published: June 2021

The technical characteristics of women’s basketball may differ from men’s basketball, and there is a need to identify the key performance indicators (KPIs) that contribute to the success of women’s teams. The aim of the current study was to examine and quantify the relationships between technical performance indicators and match outcome in elite women’s basketball using both linear and non-linear statistical methods, the effectiveness of the two methods was compared as well. A total of 136 matches (n = 272 teams’ observations) in the regular season of Women’s Chinese Basketball Association (WCBA; season 2020–2021) were analyzed using multiple linear regression (MLR) and quantile regression (QR). Results showed that two-point percentage, offensive rebounds, assists and turnovers had significant effects on the match outcome for both MLR and QR analysis. No significant relationships were observed between match outcome and three-point percentage, steals, and fouls. The results between MLR and QR analysis were different in free-throw percentage, defensive rebounds and blocks. Current results highlighted QR analysis is an advanced statistical model more powerful than the traditional linear method for the identification of KPIs. The identified KPIs may help coaches to develop more specific training interventions and match strategies during match play.
Diagnostic Accuracy of the Drug Use Disorder Identification Test and Its Short Form, the DUDIT-C, in German Adolescent Psychiatric Patients
Authors: Basedow Lukas A. , Kuitunen-Paul Sören , Eichler Anna , Roessner Veit , Golub Yulia
Published: June 2021

Background

A common screening instrument for substance use disorders (SUDs) is the Drug Use Disorders Identification Test (DUDIT) which includes a short form regarding only drug consumption (DUDIT-C). We aim to assess if a German version of the DUDIT, adapted for adolescents, is a suitable screening instrument in a sample of adolescent psychiatric patients.

Methods

N = 124 (54 female) German adolescent (M = 15.6 + 1.5 years) psychiatric patients completed the DUDIT and received a diagnostic interview (MINI-KID) assessing DSM-5 SUD criteria. A confirmatory factor analysis (CFA), receiver operating characteristic (ROC) curves, the area under the curve (AUC), and Youden’s Index were calculated.

Results

A two-factor model of the DUDIT shows the best model fit (CFI = 0.995, SRMR = 0.055, RMSEA = 0.059, WRMR = 0.603). The DUDIT as well as the DUDIT-C show high diagnostic accuracy, with AUC = 0.95 and AUC = 0.88, respectively. For the DUDIT a cut-off value of 8.5 was optimal (sensitivity = 0.93, specificity = 0.91, J = 0.84), while for the DUDIT-C the optimal cut-off value was at 1.5 (sensitivity = 0.86, specificity = 0.84, J = 0.70).

Conclusion

This is the first psychometric evaluation of the DUDIT in German, adolescent psychiatric outpatients, using the DSM-5 diagnostic criteria. The DUDIT as well as the DUDIT-C are well suited for use in this population. Since in our sample only few patients presented with a mild or moderate SUD, our results need to be replicated in a sample of adolescents with mild SUD.
Understanding the Impact of Social Capital on Entrepreneurship Performance: The Moderation Effects of Opportunity Recognition and Operational Competency
Authors: Xie Gui-hua , Wang Lin-ping , Lee Bey-fen
Published: June 2021

Social capital, which is derived from psychological research, has an important value in the construction of network relationships in enterprises. It influences the direction and tendency of network connections in start-up enterprises and has gradually become an important factor in the study of entrepreneurship by scholars. However, the relationship between this and the effectiveness of innovation is unclear. In this study, the social capital is divided into bonding social capital and bridging social capital, and specific data of agricultural entrepreneurs are collected through questionnaire surveys. The results show that both bonding and bridging social capital have a significant positive effect on agricultural entrepreneurship performance. The entrepreneurial capacity of agricultural entrepreneurs regulates the relationship between social capital and creative performance. In the relationship between integrated social capital and creative performance, operational competency plays a positive role and opportunity recognition plays a negative role. On the other hand, in the relationship between bridging social capital and creative performance, the opportunity recognition plays a positive role and the operational competency plays a negative role. Finally, based on the above findings, this study proposes theoretical and practical implications and suggestions for follow-up research.
Psychiatrization of Society: A Conceptual Framework and Call for Transdisciplinary Research
Authors: Beeker Timo , Mills China , Bhugra Dinesh , te Meerman Sanne , Thoma Samuel , Heinze Martin , von Peter Sebastian
Published: June 2021

Purpose:Worldwide, there have been consistently high or even rising incidences of diagnosed mental disorders and increasing mental healthcare service utilization over the last decades, causing a growing burden for healthcare systems and societies. While more individuals than ever are being diagnosed and treated as mentally ill, psychiatric knowledge, and practices affect the lives of a rising number of people, gain importance in society as a whole and shape more and more areas of life. This process can be described as the progressing psychiatrization of society.

Methods:This article is a conceptual paper, focusing on theoretical considerations and theory development. As a starting point for further research, we suggest a basic model of psychiatrization, taking into account its main sub-processes as well as its major top-down and bottom-up drivers.

Results:Psychiatrization is highly complex, diverse, and global. It involves various protagonists and its effects are potentially harmful to individuals, to societies and to public healthcare. To better understand, prevent or manage its negative aspects, there is a need for transdisciplinary research, that empirically assesses causes, mechanisms, and effects of psychiatrization.

Conclusion:Although psychiatrization has highly ambivalent effects, its relevance mainly derives from its risks: While individuals with minor disturbances of well-being might be subjected to overdiagnosis and overtreatment, psychiatrization could also result in undermining mental healthcare provision for the most severely ill by promoting the adaption of services to the needs and desires of the rather mild cases. On a societal level, psychiatrization might boost medical interventions which incite individual coping with social problems, instead of encouraging long-term political solutions.
A Systematic Review of Autobiographical Memory and Mental Health Research on Refugees and Asylum Seekers
Authors: Khan Sanjida , Kuhn Sara K. , Haque Shamsul
Published: June 2021

Research examining trauma, memory, and mental health among refugee and asylum-seeking people has increased in recent years. We systematically reviewed empirical work focusing on the link between autobiographical memory and mental health among these populations. The review protocol was registered with PROSPERO (CRD42018095888). Six major databases were searched in August-2020 with no time limit for publication. Following PRISMA Statement guidelines, 22 articles reporting ten quantitative, nine qualitative, and three mixed-method studies were selected from 254 articles identified in the initial search. A basic convergent and qualitative meta-integration technique was employed for data extraction. Four recurrent themes were extracted: (1) memory activation method, (2) memory features, (3) memory content, and (4) refugee mental health. Theme 1 illustrates that narrative interviews, important event recall, and cue word methods were used in most studies. Theme 2 highlights that memories of refugee people were often less specific, inconsistent, and negative-focused. Retrieval failure was also common among these people. Theme 3 reveals that refugee and asylum-seeking people frequently discussed their abandoned identities, lost resources, injustices, ongoing sufferings, and pointless futures. Finally, theme 4 identifies the prevalence of various mental health conditions like Post-traumatic Stress Disorder, depression, helplessness, and anger among these people. The results are discussed in the context of the current autobiographical memory and mental health theories, considering refugee-specific experiences in the asylum process and refugee status.
Association Between Food Choices Motivators and Physical Activity in Body Image (dis)Satisfaction in Portuguese Adolescents
Authors: Dias Sara Simões , Lages Marlene , Frontini Roberta , Luís Luís , Dixe Maria dos Anjos , Sousa Pedro
Published: June 2021

Concerns about weight and body image are common among adolescents since they are particularly vulnerable to body-image dissatisfaction due to the normal physiological, social, and psychological changes they are going through. This study aims to analyse the relationship between food choice motivations and physical activity in body-image perception among adolescents. Twelve to sixteen years old adolescents were recruited from three school districts. The Portuguese version of the Food Choices Questionnaire (FCQ) was used to assess food choice motivators, and the Quantification de l'Activité Physique en Altitude Chez les Enfants was used to assess physical activity and to calculate daily energy expenditure (DEE). Body image perception was measured using Collins' sequence of seven silhouettes. Body image (dis)satisfaction was estimated by the present body shape minus the desired body shape. ANOVA and Kruskal-Wallis tests were performed to compare groups, and the post-hoc Bonferroni test was used to compare target groups. A multinominal logistic regression was performed to analyse the association between gender, age, hours of sport's competition, FCQ, and body dissatisfaction. All analyses were performed in IBM SPSS Statistics 26.0. The sample comprised 286 adolescents (51.4% females). Means of FCQ categories varied between 0.33 and 0.97 (range: −2 to 2). Regarding the categories of FCQ, statistically significant differences were found in the category of body satisfaction and weight control among the three groups (p = 0.004). A preventive effect was found of choosing food regarding body satisfaction and weight control, on body-image dissatisfaction.
System Thinking and Citizen Participation Is Still Missing in One Health Initiatives – Lessons From Fifteen Evaluations
Authors: Hitziger Martin , Berezowski John , Dürr Salome , Falzon Laura C. , Léchenne Monique , Lushasi Kennedy , Markosyan Tigran , Mbilo Céline , Momanyi Kelvin N. , Özçelik Ranya , Prejit Nambiar , Zinsstag Jakob , Rüegg Simon R.
Published: June 2021

Tackling complex public health challenges requires integrated approaches to health, such as One Health (OH). A key element of these approaches is the integration of knowledge across sectors, disciplines and stakeholders. It is not yet clear which elements of knowledge integration need endorsement to achieve best outcomes. This paper assesses 15 OH initiatives in 16 African, Asian and European countries to identify opportunities to improve knowledge integration and to investigate geographic influences on knowledge integration capacities. Two related evaluation tools, both relying on semi-quantitative questionnaires, were applied to two sets of case studies. In one tool, the questions relate to operations and infrastructure, while the other assigns questions to the three phases of “design,” “implementation,” and “evaluation” of the project life cycle. In both, the question scores are aggregated using medians. For analysis, extreme values were identified to highlight strengths and weaknesses. Seven initiatives were assessed by a single evaluator external to the initiative, and the other eight initiatives were jointly assessed by several internal and external evaluators. The knowledge integration capacity was greatest during the project implementation stage, and lowest during the evaluation stage. The main weaknesses pointing towards concrete potential for improvement were identified to be a lack of consideration of systemic characteristics, missing engagement of external stakeholders and poor bridging of knowledge, amplified by the absence of opportunities to learn and evolve in a collective process. Most users were unfamiliar with the systems approach to evaluation and found the use of the tools challenging, but they appreciated the new perspective and saw benefits in the ensuing reflections. We conclude that systems thinking and associated practises for OH require not only specific education in OH core competencies, but also methodological and institutional measures to endorse broad participation. To facilitate meta-analyses and generic improvement of integrated approaches to health we suggest including knowledge integration processes as elements to report according to the COHERE guidelines.
Evaluation of MRI Denoising Methods Using Unsupervised Learning
Authors: Moreno López Marc , Frederick Joshua M. , Ventura Jonathan
Published: June 2021

In this paper we evaluate two unsupervised approaches to denoise Magnetic Resonance Images (MRI) in the complex image space using the raw information that k-space holds. The first method is based on Stein’s Unbiased Risk Estimator, while the second approach is based on a blindspot network, which limits the network’s receptive field. Both methods are tested on two different datasets, one containing real knee MRI and the other consists of synthetic brain MRI. These datasets contain information about the complex image space which will be used for denoising purposes. Both networks are compared against a state-of-the-art algorithm, Non-Local Means (NLM) using quantitative and qualitative measures. For most given metrics and qualitative measures, both networks outperformed NLM, and they prove to be reliable denoising methods.
Linking Linguistic and Geographic Distance in Four Semantic Domains: Computational Geo-Analyses of Internal and External Factors in a Dialect Continuum
Authors: Huisman John L. A. , Franco Karlien , van Hout Roeland
Published: June 2021

Dialectometry studies patterns of linguistic variation through correlations between geographic and aggregate measures of linguistic distance. However, aggregating smooths out the role of semantic characteristics, which have been shown to affect the distribution of lexical variants across dialects. Furthermore, although dialectologists have always been well-aware of other variables like population size, isolation and socio-demographic features, these characteristics are generally only included in dialectometric analyses afterwards for further interpretation of the results rather than as explanatory variables. This study showcases linear mixed-effects modelling as a method that is able to incorporate both language-external and language-internal factors as explanatory variables of linguistic variation in the Limburgish dialect continuum in Belgium and the Netherlands. Covering four semantic domains that vary in their degree of basic vs. cultural vocabulary and their degree of standardization, the study models linguistic distances using a combination of external (e.g., geographic distance, separation by water, population size) and internal (semantic density, salience) sources of variation. The results show that both external and internal factors contribute to variation, but that the exact role of each individual factor differs across semantic domains. These findings highlight the need to incorporate language-internal factors in studies on variation, as well as a need for more comprehensive analysis tools to help better understand its patterns.
An Immersive Investment Game to Study Human-Robot Trust
Authors: Zörner Sebastian , Arts Emy , Vasiljevic Brenda , Srivastava Ankit , Schmalzl Florian , Mir Glareh , Bhatia Kavish , Strahl Erik , Peters Annika , Alpay Tayfun , Wermter Stefan
Published: June 2021

As robots become more advanced and capable, developing trust is an important factor of human-robot interaction and cooperation. However, as multiple environmental and social factors can influence trust, it is important to develop more elaborate scenarios and methods to measure human-robot trust. A widely used measurement of trust in social science is the investment game. In this study, we propose a scaled-up, immersive, science fiction Human-Robot Interaction (HRI) scenario for intrinsic motivation on human-robot collaboration, built upon the investment game and aimed at adapting the investment game for human-robot trust. For this purpose, we utilize two Neuro-Inspired COmpanion (NICO) - robots and a projected scenery. We investigate the applicability of our space mission experiment design to measure trust and the impact of non-verbal communication. We observe a correlation of 0.43 (p=0.02) between self-assessed trust and trust measured from the game, and a positive impact of non-verbal communication on trust (p=0.0008) and robot perception for anthropomorphism (p=0.007) and animacy (p=0.00002). We conclude that our scenario is an appropriate method to measure trust in human-robot interaction and also to study how non-verbal communication influences a human’s trust in robots.
Cosmic Tango Between the Very Small and the Very Large: Addressing CMB Anomalies Through Loop Quantum Cosmology
Authors: Ashtekar Abhay , Gupt Brajesh , Sreenath V.
Published: June 2021

While the standard, six-parameter, spatially flat ΛCDM model has been highly successful, certain anomalies in the cosmic microwave background bring out a tension between this model and observations. The statistical significance of any one anomaly is small. However, taken together, the presence of two or more of them imply that according to standard inflationary theories we live in quite an exceptional Universe. We revisit the analysis of the PLANCK collaboration using loop quantum cosmology, where an unforeseen interplay between the ultraviolet and the infrared makes the primordial power spectrum scale dependent at very small k. Consequently, we are led to a somewhat different ΛCDM Universe in which anomalies associated with large scale power suppression and the lensing amplitude are both alleviated. The analysis also leads to new predictions for future observations. This article is addressed both to cosmology and loop quantum gravity communities, and we have attempted to make it self-contained.
Platelet-Rich Plasma Combined With Autologous Grafting in the Treatment of Long Bone Delayed Union or Non-union: A Meta-Analysis
Authors: An Weijun , Ye Peng , Zhu Tao , Li Zhizhong , Sun Jianbin
Published: June 2021

Background: Platelet-rich plasma (PRP) has been suggested as an emerging treatment for bone defects. However, whether PRP could enhance the therapeutic efficacy of autologous bone grafting for long bone delayed union or non-union remains unknown. A meta-analysis of randomized and non-randomized controlled trials (RCT and NRCT) was performed to summarize current evidence.

Methods: Relevant RCTs and NRCTs comparing the influences of autologous bone grafting on healing of long bone delayed union or non-union with and without PRP were obtained by searching PubMed, Embase, Cochrane's Library, China National Knowledge Infrastructure, and WanFang databases from inception to September 10, 2020. A random-effect model was applied to pool the results with the incorporation of the potential heterogeneity. Subgroup analysis according to study design was also performed.

Results: Six RCTs and two NRCTs with 420 patients were included. Compared to patients allocated to autologous bone grafting alone, those allocated to combined treatment with PRP and autologous bone grafting were not associated with higher rates of radiographic bone healing [risk ratio (RR): 1.06, 95% confidence interval (CI): 0.99–1.13, P = 0.09; I2 = 24%] or excellent/good posttreatment limb function (RR: 1.14, 95% CI: 0.95–1.37, P = 0.37; I2 = 0%) but was associated with a shorter healing time (mean difference: −1.35 months, 95% CI: −1.86 to −0.84, P < 0.001; I2 = 58%). Subgroup analysis according to study design showed similar results for the above outcomes (P-values for subgroup difference all >0.10).

Conclusions: Combined treatment with PRP and autologous bone grafting may be effective to accelerate the healing of long bone delayed union or non-union compared to autologous bone grafting alone.
Lessons Learned in 11 Years of Experience With Open Abdomen Treatment With Negative-Pressure Therapy for Various Abdominal Emergencies
Authors: Gasser Elisabeth , Rezaie Daniel , Gius Johanna , Lorenz Andreas , Gehwolf Philipp , Perathoner Alexander , Öfner Dietmar , Kafka-Ritsch Reinhold
Published: June 2021

Introduction: Open abdomen (OA) treatment with negative-pressure therapy (NPT) was initiated for perforated diverticulitis and subsequently extended to other abdominal emergencies. The aim of this retrospective study was to analyze the indications, procedures, duration of NPT, and the outcomes of all our patients.

Methods: All consecutive patients treated with intra-abdominal NPT from January 1, 2008 to December 31, 2018 were retrospectively analyzed.

Results: A total of 438 patients (44% females) with a median (range) age of 66 (12–94) years, BMI of 25 (14–48) kg/m2, and ASA class I, II, III, and IV scores of 36 (13%), 239 (55%), 95 (22%), and 3(1%), respectively, were treated with NPT. The indication for surgery was primary bowel perforation in 163 (37%), mesenteric ischemia in 53 (12%), anastomotic leakage in 53 (12%), ileus in 53 (12%), postoperative bowel perforation/leakage in 32 (7%), abdominal compartment in 15 (3%), pancreatic fistula in 13 (3%), gastric perforation in 13 (3%), secondary peritonitis in 11 (3%), burst abdomen in nine (2%), biliary leakage in eight (2%), and other in 15 (3%) patients. A damage control operation without reconstruction in the initial procedure was performed in 164 (37%) patients. The duration of hospital and intensive care stay were, median (range), 28 (0–278) and 4 (0–214) days. The median (range) duration of operation was 109 (22–433) min and of NPT was 3(0–33) days. A trend to shorter duration of NPT was observed over time and in the colonic perforation group. The mean operating time was shorter when only blind ends were left in situ, namely 110 vs. 133 min (p = 0.006). The mortality rates were 14% at 30 days, 21% at 90 days, and 31% at 1 year. An entero-atmospheric fistula was observed in five (1%) cases, most recently in 2014. Direct fascia closure was possible in 417 (95%) patients at the end of NPT, but least often (67%, p = 0.00) in patients with burst abdomen. During follow-up, hernia repair was observed in 52 (24%) of the surviving patients.

Conclusion: Open abdomen treatment with NPT is a promising concept for various abdominal emergencies, especially when treated outside normal working hours. A low rate of entero-atmospheric fistula formation and a high rate of direct fascia closure were achieved with dynamic approximation of the fascia edges. The authors recommend an early-in and early-out strategy as the prolongation of NPT by more than 1 week ends up in a frozen abdomen and does not improve abdominal sepsis.
Potential and Challenges of Community-Based Surveillance in Animal Health: A Pilot Study Among Equine Owners in Switzerland
Authors: Özçelik Ranya , Remy-Wohlfender Franziska , Küker Susanne , Visschers Vivianne , Hadorn Daniela , Dürr Salome
Published: June 2021

Animal owners' potential to observe and report clinical signs, as the persons with the closest contact to their animals, is an often neglected source of information in surveillance. Allowing community members other than health care professionals, such as animal owners, to report health events can contribute to close current surveillance gaps and enhance early detection. In the present study, we tested a community-based surveillance (CBS) approach in the equine community in Switzerland. We aimed at revealing the attitudes and intentions of equine owners toward reporting clinical signs by making use of an online questionnaire. We further set up and operated an online CBS tool, named Equi-Commun. Finally, we investigated potential reasons for the lack of its use by applying qualitative telephone interviews. The majority of the respondents of the online questionnaire (65.5%, 707/1,078) answered that they could see themselves reporting clinical observations of their equine. The multivariate logistic regression analysis indicated that French-speaking equine owners and those belonging to the positive attitude cluster are more likely to report to a CBS tool. Equi-Commun operated between October 2018 and December 2019 yet received only four reports. With the addition of qualitative interviews, we identified three critical, interlinked issues that may have led to the non-use of Equi-Commun within the Swiss equine community: (1) for successfully implementing CBS, the need for surveillance within the community of interest must be given; (2) the respective population under surveillance, here the equine, needs to show enough clinical cases for owners to be able to maintain the memory of an existing tool and its possible use; and (3) targeted and high effort communication of the system is key for its success. While CBS relying only on lay animal owners, complementary to existing surveillance systems, could potentially provide a good proxy of timely surveillance data, it is questionable whether the added value of generated surveillance knowledge is in balance with efforts necessary to implement a successful system. With this study, we showcased both the potential and challenges of CBS in animal health, as this may be of relevance and guidance for future initiatives.
Airborne Spread of Methicillin Resistant Staphylococcus aureus From a Swine Farm
Authors: Angen Øystein , Nielsen Martin Weiss , Løfstrøm Per , Larsen Anders Rhod , Hendriksen Niels Bohse
Published: June 2021

Spread of livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA) to farmworkers has been recognized as a risk when working in LA-MRSA positive stables, due to LA-MRSA being present on airborne dust particles. Based on this, airborne spread of LA-MRSA through stable vents is a concern that is addressed in this study. The aim of the investigation was to quantify the airborne spread of LA-MRSA from a MRSA positive swine farm. In order to achieve this, a method for sampling large volumes of air was applied. The results were compared to meteorological data and bacteriological investigation of samples from the air inside the swine barn, soil outside the farm, and nasal samples from the individuals participating in the sampling process. MRSA was detected up to 300 m (the maximal measuring distance) from the swine farm in the air but only at low levels at distances above 50 meters (0.085 CFU/m3 at a distance of 50 m in the wind plume). MRSA was detected in sock samples obtained at the soil surfaces up to 400 m (the maximal measuring distance) from the farm building. The proportion of MRSA positive soil samples decreased from ~80 to 30% with increasing distance from the farm. A total of 25 human nasal samples were sampled after the farm visits after the participants had stayed in the surroundings of the farm for an average of 10.5 h. When leaving the farm, only two of the samples (8%) were LA-MRSA-positive both obtained from one individual who was the one who had sampled the ventilation shafts. In conclusion, airborne spread of MRSA from swine farms does not seem to be an important route for human contamination for individuals staying a whole working day outside a swine farm.
Chemical Analysis and Anthelmintic Activity Against Teladorsagia Circumcincta of Nordic Bark Extracts In vitro
Authors: Athanasiadou Spiridoula , Almvik Marit , Hellström Jarkko , Madland Eva , Simic Nebojsa , Steinshamn Håvard
Published: June 2021

Helminth parasitic infections are common in small ruminants in Norway; infection is usually treated with anthelmintic drugs, but anthelmintic resistance is an increasing problem. It is necessary to identify strategies to reduce the use of anthelmintic drugs and mitigate the impact of anthelmintic resistance. Condensed tannin (CT)-rich forages have been shown to reduce the helminth burden in small ruminants, but these forages have limited cultivation potential in Scandinavia. A good source for CT in cold climatic regions may be the bark of several commercially utilized tree species. In the present study, we determined the content and characterized the type of CT in bark extracts of pine (Pinus sylvestris L.), spruce (Picea abies L.), and birch (Betula pubescens). Extracts of selected bark samples were tested for their anthelmintic efficacy against the ovine infectious nematode Teladorsagia circumcincta. Total CT content was higher in the bark from younger (10–40 years old) pine and spruce trees; it decreased with tree age in pine, whereas it remained relatively stable in the bark of spruce and birch. Pine trees consisted of 100% procyanidins, whereas prodelphinins were present in most spruce (4–17%) and all birch samples (5–34%). Our studies clearly showed that there is variation in the anthelmintic activity of water and acetone extracts of bark samples collected from various sites around Norway, as this was measured with two independent in vitro assays, the egg hatch and larvae motility assays. The anthelmintic activity of some extracts was consistent between the two assays; for example, extracts from the three samples with the highest CT content showed very high activity in both assays, whereas the extract from the sample with the lowest CT content showed the lowest activity in both assays. For other extracts, activity was not consistent across the assays, which could be attributed to the susceptibility of the different stages of the parasitic life cycle. We demonstrated that bark extracts from commercially used trees in Scandinavia have the potential to be used as alternatives to anthelmintics. Further work should focus on refining the associations between bark extracts and anthelmintic activity to identify the best strategies to reduce the input of anthelmintic drugs in livestock production systems.