bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing Human Development Quality in Indonesia: Socio-Economic and Technological Capabilities
Authors: Setyowati Ika Yuli , Malik Nazaruddin , Suliswanto Muhammad Sri Wahyudi
Published: April 2024

Research Originality: Human development is a complex issue faced by various countries worldwide. Technology is considered to have the potential to significantly impact the landscape of human development due to its potential for penetration. This research contributes to the development literature in Indonesia by focusing on the important aspects of the influence of socio-economic factors and technological capabilities on the quality of human development.Research Objectives: This research aims to analyse how socio-economic and technological capabilities influence the quality of human development in Indonesia.Research Methods: Using panel data from 34 provinces spanning the period from 2015 to 2022, the research employs a Panel Data Regression Analysis model with the best-fitted Fixed Effect model.Empirical Results: The results of this study indicate that socio-economic factors, as seen through unemployment and poverty, significantly negatively impact Indonesia's Human Development Index (HDI). Economic growth has an insignificant effect on Indonesia's HDI. Technological capabilities, measured through the ICT Development Index, and the proportion of adolescents and adults aged 15-59 with ICT skills, have a significantly positive impact on Indonesia's HDI.Implications: The results of this research identify factors that can either encourage or hinder HDI, offering valuable insights for government policymakers to enhance HDI in Indonesia, particularly in each region.JEL Classification: O15, O30, O47How to Cite:Setyowati, I. Y., Malik, N., & Suliswanto, M.S.W. (2024). Enhancing Human Development Quality in Indonesia: Socio-Economic and Technological Capabilities. Etikonomi, 23(1), 93 – 108. https://doi.org/10.15408/etk.v23i1.35508.
Volatility Connectedness of MOVE Index and Bond Returns
Authors: Baykut Ender , Gökgöz Halilibrahim
Published: April 2024

Research Originality: To the best of our knowledge, this is the first study which measures the impact of the MOVE index on bond yield volatility by comparing its effect on both short-term and long-term. The paper contributes to the existing literature by providing a better understanding of the relationship between maturity and volatility spillover. Research Objectives: This study examines the dynamic volatility connectedness between 2 and 10-year bond yields and the MOVE Index. Furthermore, it is aimed at detecting the transmitter of volatility among variables. Research Methods: Using a data set from 2010 to 2022, the study utilizes a Time-Varying Parameter Vector Autoregression (TVP-VAR) model to analyse the dynamics and relationship between bond yields and the MOVE Index. Empirical Results: The study finds a significant volatility spillover between the MOVE Index and Türkiye's bond yields. Notably, the linkage between the MOVE Index and the 10-year bond rates is stronger than with the 2-year rates. Additionally, the MOVE Index emerges as the primary transmitter of volatility, impacting both bond yields. Implications: This study sheds light on the complexity and dynamics of volatility spread in Türkiye's bond market, providing essential insights for forecasting bond yields and shaping financial policies.JEL Classification: G17, C22, G12How to Cite:Baykut, E., Gökgöz, H. (2024). Volatility Connectedness of MOVE Index and Bond Returns. Etikonomi, 23(1), 27 – 46. https://doi.org/10.15408/etk.v23i1.36131.
The Intention of Young Muslim Generation to Use the Islamic E-Wallet Services in Indonesia
Authors: Risza Handi
Published: April 2024

Research Originality: Technological developments have changed human behavior in economic activities, including payment methods that use e-wallets. On the other hand, consumers also need an e-wallet that complies with Sharia principles. The COVID-19 pandemic forced consumers to use digital payment methods. However, the number of studies related to the continued usage of Islamic e-wallets in Indonesia remains limited.Research Objectives: Hence, our study examines the factors influencing a person's intention to use an Islamic e-wallet.Research Method: The theoretical framework used in this study is the Technology Acceptance Model. The analysis technique employed is multiple regression analysis using 371 respondents.Result: Empirical results indicate that the factors influencing a person's intention to use an Islamic e-wallet are usability, ease of use, trustworthiness, and religiosity. However, the risk variable does not significantly affect a person's intention to use an Islamic e-wallet. Implication: These results imply that companies must improve the features and services of Islamic e-wallet applications.JEL Classification: D10, G29How to Cite:Risza, H. (2024). The Intention of Young Muslim Generation Using the Islamic E-wallet Services in Indonesia. Etikonomi, 23(1), 219 – 232. https://doi.org/10.15408/etk.v23i1.37452.
Confidentiality in the Care of Adolescents: Technical Report
Authors: Chung Richard J. , Lee Janet B. , Hackell Jesse M. , Alderman Elizabeth M. ,   COMMITTEE ON ADOLESCENCE, Alderman Elizabeth M. , Berlan Elise D. , Chung Richard J. , Colburn Michael , Lee Janet , Monge Maria , Shafii Taraneh , Grubb Laura K. , Wallace Stephenie B. , Amies Anne-Marie , Hua Liwei L. , Menon Seema , Rahmandar Maria H. , Vyver Ellie , Zapata Lauren , Smith Karen S. , Baumberger James ,   COMMITTEE ON PRACTICE & AMBULATORY MEDICINE, Hackell Jesse , Almendarez Yvette Marie , Berhane Abeba Mebrahtu , Cantrell Patricia E. , Kafer Lisa Michele , Latimer Tomitra , Warner Robin , Wiskind Robert H. , Skatrud Alisa , Kaplan Seth , English Abigail , Magnus Mackenzie , Ferguson Elisha
Published: April 2024

Confidentiality is a foundational element of high-quality, accessible, and equitable health care. Despite strong grounding in federal and state laws, professional guidelines, and ethical standards, health care professionals and adolescent patients face a range of complexities and barriers to seeking and providing confidential care to adolescents across different settings and circumstances. The dynamic needs of adolescents, the oftentimes competing interests of key stakeholders, the rapidly evolving technological context of care, and variable health care billing and claims requirements are all important considerations in understanding how to optimize care to focus on and meet the needs of the adolescent patient. The following assessment of the evolving evidence base offers a view of the current state and best practices while pointing to numerous unmet needs and opportunities for improvement in the care experiences of youth as well as their health outcomes.
Understanding Employer Attractiveness for Generation Z in the IT Industry
Authors: Hofer Teresa , Spiess Teresa , Ploder Christian , Bernsteiner Reinhard
Published: April 2024

Purpose: This research delves into understanding the selection criteria of Generation Z, specifically those with an IT education background, in choosing potential employers. The study aims to bridge the gap in knowledge regarding employer attractiveness from the perspective of this emerging workforce cohort.

Design/Method/Approach: A quantitative approach was employed, utilizing a survey method to gather data. The study predominantly targeted students from an Austrian business school, resulting in a sample size of 156 respondents. The survey included a Conjoint Analysis to evaluate various employer attributes.

Findings: The findings highlight the significance of workplace flexibility, Work-Life Balance, and meaningful, varied job tasks for Generation Z. Salary emerged as a crucial factor influencing their choice of an attractive employer. While symbolic attributes were slightly more critical than instrumental ones, no significant impact of professional experience on the perceived relevance of symbolic attributes was found.

Theoretical Implications: The study enriches the Instrumental-Symbolic Framework by validating the importance of symbolic attributes for Generation Z.

Practical Implications: Practitioners can leverage these insights to tailor their Employer Branding strategies to attract Generation Z, focusing on flexible work arrangements, meaningful work, and competitive salaries.

Originality/Value: This research provides new insights into the preferences of Generation Z in the IT sector, highlighting the nuanced differences in their employer selection criteria compared to previous generations.

Research Limitations/Future Research: The study’s limitations include its focus on two specific educational institutions and the lack of rural-urban differentiation among respondents. Future research could explore these criteria across diverse geographic and institutional contexts.

Paper Type: Empirical

JEL Сlassіfіcatіon: J24, M12, M51
THE FUTURE: FIAT CURRENCIES OR CRYPTOCURRENCIES
Authors: Kolyandov S.
Published: April 2024

This report attempts to look into the future of the global monetary system. The history and development of fiat currencies is reviewed, their strengths and weaknesses are presented, causing market stability or instability and recession, respectively. Attention is paid to the global processes affecting the traditional money markets and the accumulated experience of the institutions to deal with the crises. The increasing digitization in the industry, the economy and the daily life of every single person inevitably gives rise to the need for the use of digital currency to guarantee transactions between individual parties. The idea for these still unrealized needs was born nearly 40 years ago, and the first realization took place in 1996, when e-gold was born. Today, we have hundreds of cryptocurrencies that still operate in an unregulated market, and their legal status still varies from country to country. The desire of individual countries and banking institutions to start their legally regulated use by already developing and testing their own currencies is presented.
THE DIGITAL TRANSFORMATION OF AGRICULTURAL BUSINESS - MARKET TRENDS AND CHALLENGES
Authors: Nencheva I. , Penev N.
Published: April 2024

Digital transformation is necessary for today's business to remain relevant, competitive and successful. Different technologies bring different benefits to businesses. They help to organize and optimize processes, work more efficiently and create successful products and services.
Hybridization of CSA and PSO improves the efficacy of MPPT for solar photovoltaic array with partial shading
Authors: Challoob Ali Falih , Bin Rahmat Nur Azzammudin , A/L Ramachandaramurthy Vigna K. , Humaidi Amjad J.
Published: April 2024

One critical issue in the tracking systems based on photovoltaic (PV) is how to harvest highest power of the photovoltaic array; particularly when the system is operating in partially shaded conditions (PSCs) or varying irradiances. This study proposes particle swarm optimization (PSO) hybridization and cuckoo search algorithm (CSA) methods for maximum power point tracking (MPPT). The effectiveness of the proposed algorithm is validated and examined under various irradiance patterns. A comparison study in performance has been conducted between the proposed hybrid CSA-PSO method with the conventional P&O and PSO techniques. Several tests have been performed based on numerical simulations utilizing the programming software MATLAB/Simulink. The results demonstrated that the suggested hybrid technique yields smaller tracking time, higher power and greater efficiency than those of other traditional algorithms.
Business strategy of for-profit-oriented sports enterprises in Hungary
Authors: Bácsné Bába Éva , Szabados György Norbert , Orbán Szabolcs Gergely , Bács Zoltán , Balogh Renátó , Kovács Sándor
Published: April 2024

Many sports organisations operate as non-profits, but the emphasis and role of for-profits in this sector cannot be avoided. Today, sports activities are connected to the business sector and generate profit, hence, sports sector is a decisive part of the economy. Sport profile companies differ in their organisational strategy formulation approach. The main focus was to learn more about their strategy approach and market behaviour. 350 sports business organisations were involved in a survey of 3,248 companies, and the Chi-square test, variance analysis, and principal component analysis were applied to the sample. Results showed that 75.7% of the responding sports companies had no written strategic plan. The availability of written strategies seemed to depend on the organisation's scale. The market-following behaviour was confirmed in the case of smaller sports enterprises. Fitness service providers appeared to follow a market-leading behaviour. Growth, investment, and development naturally emerged as essential factors for companies with higher sales revenue and operating sports facilities, and they were relatively less important in sports goods production and trade. Most of the results showed that in the sports business sector, large-scale organisations focus on strategic-related issues more than other players in the industry.
Simultaneous Approximation for an Exponential Operator Connected with x4/3
Authors: Anjali  , Gupta Vijay
Published: April 2024

Very recently, the authors in [5] proposed the exponential-type operator connected with and studied its convergence estimates. In the present research, we extend the study and obtain the general form of its 𝑝-th order moment; 𝑝 ∈ ℕ ∪ {0}. Further, we establish the simultaneous approximation for the operator under consideration.
Podstawy ideowe władzy kościelnej i władzy świeckiej w myśli Grzegorza VII – analiza wybranych fragmentów pism z papieskiego regestru
Authors: Zdziech Karol
Published: April 2024

Wiek XI był czasem przełomowym w historii Kościoła łacińskiego. Wewnętrzna potrzeba reform i moralnej naprawy doprowadziła do wielu zmian w strukturach Kościoła i jego hierarchii. Ponieważ główną siłą, która przeprowadzała reformy wewnątrzkościelne, było papiestwo, a także kręgi duchowieństwa z nim związane, jego pozycja w relacjach z innymi biskupstwami znacznie się wzmocniła. Mimo że okres religijnych reform i wzrostu znaczenia Stolicy Apostolskiej trwał od pontyfikatu Leona IX, to Grzegorz VII jest uważany za najwybitniejszego przedstawiciela tego czasu w historii Kościoła. Właśnie od jego imienia okres zmian został nazwany „reformą gregoriańską”. Dzięki szczęśliwemu przetrwaniu do naszych czasów regestru tegoż papieża w dużej mierze można poznać jego pogląd na kwestię podstaw ideowych władzy duchowej i świeckiej. Najbardziej klarownym źródłem do ich poznania jest notatka Dictatus pape, którą uzupełniają wybrane listy Grzegorza VII wysłane do świeckich monarchów. Poglądy papieża na charakter władzy biskupa Rzymu można uznać za radykalne – widział on swój urząd jako nadrzędną władzę nie tylko nad całym duchowieństwem, ale także nad władcami świeckimi.
Przedsiębiorstwo „Centrala Rybna” w latach 1945–1989. Przyczynek do badań
Authors: Kubicki Mateusz
Published: April 2024

Odzyskanie przez Polskę po zakończeniu II wojny światowej swobodnego dostępu do Morza Bałtyckiego dawało możliwości eksploatacji łowisk na tym akwenie. W tym celu od 1945 r. komunistyczne władze dynamicznie rozwijały rybołówstwo, przetwórstwo oraz dystrybucję ryb i przetworów rybnych. Jednym z elementów tego systemu były struktury wielozadaniowego, monopolistycznego przedsiębiorstwa „Centrala Rybna” omówione na łamach niniejszego artykułu w formie przyczynku do badań. Tekst składa się z dwóch części. W pierwszej traktuje o historii powołania i zmianach strukturalnych „Centrali”. Obok prezentacji struktury scharakteryzowano zakres terytorialny działalności przedsiębiorstwa, co uwidoczniło się zwłaszcza po reformie terytorialnej z 1975 r. Omówiono też inwestycje, których głównym celem było rozszerzenie działalności podmiotu lub wymiana zdekompletowanego majątku trwałego. Pierwszą część zamyka opis procesu prywatyzacji przedsiębiorstwa. Druga partia tekstu podejmuje zagadnienia związane z rzeczywistą efektywnością. Ukazuje wielkość produkcji na tle całości dostaw rynkowych, wpływ „Centrali” na wzrost spożycia ryb i organizmów morskich, asortyment poszczególnych wyrobów ze szczególnym uwzględnieniem najbardziej zaawansowanej technologicznie produkcji konserw rybnych.
Cultural Change in Iran: Women's Rights and the Middle Class
Authors: Zahirinejad Mahnaz
Published: April 2024

The influence of Western culture and the efforts of domestic intellectuals merely scratched the surface of pre-existing and traditional practices towards women in nineteenth-century Iran. However, they led to the rise of social movements, such as the women's rights movement. Modernisation and economic growth drove ongoing processes of industrialization and urbanization during the twentieth century in Iran. Modernization also changed the social structure by creating a new middle class. It is expected that economic growth and educational attainment would empower the new middle class to demand greater political accountability, which, in turn, would lead to women's empowerment. The new middle class participated in the 1979 revolution, the outcome of which was to accelerate the rise of religious leadership. The revolutionary government renewed traditional Shiʿite practices, including traditional norms concerning women. Since the revolution, despite the imposition of Islamic law, the level of literacy and access to higher education, particularly for women, has escalated. This has led to women's awareness of their rights and their struggles to realize them in practice. However, unexpectedly, the new middle class hesitated in turning revolutionary and in joining the protestors. This research assumes that education enables women to confront their traditional roles in the family. Nevertheless, changing women's position is a process of cultural change that is coherent with both socio-economic development and the rise of a strong middle class.
Regionalne inteligentne specjalizacje a transformacja cyfrowa przedsiębiorstw w Polsce
Authors: Owczarczuk Magdalena , Trzaska Karolina
Published: April 2024

Podstawą rozwoju gospodarki cyfrowej jest szerokie wykorzystywanie przez podmioty technologii informacyjno-komunikacyjnych (ICT). Dokonująca się transformacja cyfrowa przedsiębiorstw obejmuje m.in. integrację technologii i rozwiązań cyfrowych w każdym obszarze działalności. Problemem polskiej gospodarki jest występowanie dużego zróżnicowania wykorzystania technologii informacyjnych w przedsiębiorstwach. Według wskaźnika intensywności cyfrowej w 2022 r. ponad połowa przedsiębiorstw została zaliczona do grupy o bardzo niskiej lub niskiej intensywności cyfrowej. Wysoki lub bardzo wysoki poziom intensywności wystąpił w 28,9% przedsiębiorstw. Różnice te widoczne są również na poziomie regionalnym oraz sektorowym.

Celem artykułu jest ocena intensywności cyfrowej przedsiębiorstw w Polsce oraz wskazanie znaczenia regionalnych inteligentnych specjalizacji w ich kształtowaniu. Analizując czynniki wpływające na poziom cyfryzacji regionu, sformułowano hipotezę, według której stopień absorpcji transformacji cyfrowej w województwie zależy od przyjętych regionalnych inteligentnych specjalizacji. Z badań wynika, że regionem najbardziej zaawansowanym w transformacji cyfrowej jest województwo mazowieckie, które specjalizuje się w inteligentnych systemach zarządzania, nowoczesnych usługach dla biznesu i bezpiecznej żywności. Natomiast najsłabszym pod tym względem województwem jest województwo podlaskie, gdzie regionalne inteligentne specjalizacje obejmują: sektor medyczny oraz nauk o życiu, sektor rolno-spożywczy, ekoinnowacje, nauki o środowisku, przemysł metalowo-maszynowy, szkutniczy, a także sektory powiązane z nimi łańcuchem wartości. Artykuł został przygotowany na podstawie literatury przedmiotu, programów rozwojowych Polski i UE oraz ogólnodostępnych danych statystycznych. Podstawowe metody badawcze wykorzystane w artykule to: metody wnioskowania logicznego (dedukcja i indukcja) oraz metody przetwarzania danych, tj. analiza i synteza.
(Nie)adekwatność polityki pieniężnej EBC w gospodarce spoza strefy euro na przykładzie Polski
Authors: Urbanowicz Zuzanna
Published: April 2024

Celem artykułu jest próba oceny stopnia nieadekwatności jednolitej polityki pieniężnej Europejskiego Banku Centralnego (EBC) do stabilizacyjnych potrzeb unijnej gospodarki, która nie jest członkiem strefy euro, na przykładzie gospodarki Polski. Artykuł jest kontynuacją wcześniej prowadzonych badań (Urbanowicz 2015; Klus, Paluszak, Urbanowicz 2019). Podjęty w pracy problem badawczy jest ważny dla kraju z tzw. derogacją Unii Gospodarczej i Walutowej. Status z derogacją oznacza bowiem formalne zobowiązanie kraju członkowskiego do przyjęcia wspólnej waluty. Każda z gospodarek krajów objętych derogacją będzie musiała wcześniej czy później stawić czoła konsekwencjom związanym z wystąpieniem zjawiska nieadekwatności jednolitej polityki pieniężnej w kontekście stabilizacji makroekonomicznej. Analiza została przeprowadzona dla przedziału czasu od 1 stycznia 1999 r. do 31 marca 2023 r. ze szczególnym uwzględnieniem współczesnego kryzysu finansowo-gospodarczego z 2007 r. oraz okresu pandemii i wojny w Ukrainie. Zaprezentowane wnioski mogą być podstawą do dyskusji nad przystąpieniem Polski do strefy euro.
The Interplay of Iron and Lipid Homeostasis in Non-Alcoholic Fatty Liver Disease
Authors: J. Kidman Clinton , D.S. Mamotte Cyril , Inder-Smith Keea R. , Tobin Mark J. , J. Hackett Mark , Graham Ross M.
Published: April 2024

The liver is essential for numerous metabolic functions and is the primary site of iron storage and regulation in addition to maintaining critical functions in lipid metabolism. Both iron deficiency and overload have been demonstrated as being involved with metabolic dysfunction; hence, tight regulation of iron absorption is essential to maintain health. Approximately one-third of individuals suffering from non-alcoholic fatty liver disease have elevated hepatic iron concentrations, with increased iron associated with increased disease severity, suggesting a convergence in dysregulation between lipid and iron metabolism. Increasingly, the literature is demonstrating, using a myriad of model organisms and iron-loading methods, that iron loading induces dysregulation in multiple aspects of hepatic lipid metabolism. However, the molecular mechanisms involved, and their subsequent effects on human diseases, are unclear. As iron is a fundamental component of many enzymes and proteins involved in lipid metabolism and is involved in the production of free radicals and oxidative stress, the mechanisms are numerous. In this review, we examine and summarise the dysregulation that iron loading elicits on hepatic lipid availability, de novo synthesis, catabolism, and export. We propose that understanding the interplay between iron and lipid metabolism holds the key to unlocking the complexities of disease development and progression, ultimately leading to improved therapeutic avenues.
Caracterización genética de especies acuícolas mediante paneles de SNPs de baja densidad
Authors: Max-Aguilar Adriana , Mendoza-Carrión Gabriela , Escobedo-Fregoso Cristina , Pérez-Enríquez R.
Published: April 2024

El sector acuícola presenta un elevado crecimiento con una proyección a alcanzar 106 millones de toneladas en el 2030 mundialmente. Para ello, se requiere la implementación de programas de manejo y selección genética basados en el monitoreo de la diversidad genética, la endogamia y el pedigrí de los lotes de cultivo. En este estudio se desarrolló la plataforma 2bRAD para caracterizar genéticamente especies de cultivo acuícola con paneles de baja densidad de 150 a 500 marcadores genéticos tipo SNPs (Polimorfismos de Nucleótido Simple). La implementación de la técnica 2bRAD con corte del ADN con la enzima BcgI y el uso de adaptadores con cuatro bases selectivas, generó paneles de baja densidad de 114 y 159 SNPs para el ostión del Pacífico Crassostrea gigas y el jurel Seriola rivoliana, respectivamente. Estos paneles se validaron con pruebas de parentesco y paternidad, por lo que son adecuados para estudios de diversidad genética y seguimiento del pedigrí de lotes de cultivo. El panel obtenido para el camarón Penaeus (Litopenaeus) vannamei fue de mediana densidad (2,874 SNPs), por lo que tiene otro tipo de aplicaciones. La plataforma 2bRAD desarrollada es potencialmente aplicable a otras especies de peces marinos de cultivo como huachinango, pargo lunarejo y totoaba.
Identification and functional characteristic of SARS-CoV-2-specific T lymphocytes in COVID-19 patients up to 16 months after disease onset
Authors: Vladimirov I. S. , Zhdanova A. S. , Mukhin V. E. , Makarov V. V. , Yudin V. S. , Kraevoy S. A.
Published: April 2024

In cases of respiratory viral infection, along with innate immunity mechanisms, the adaptive immune system plays a crucial role in the body’s defence. The efficiency of its cellular component is crucial for pathogen elimination. T cell response is detected in almost all cases of COVID-19, being among the key factors of the virus control and resistance to infection, including re-infection. So far, however, many aspects of cellular immune response to SARS-CoV-2 over one year or later after infection remain unclear. The aim of this study was to investigate the dynamics of laboratory parameters of post-infection cellular immunity to SARS-CoV-2 within 16 months from the symptoms’ onset.

Fifteen healthy volunteers and 87 COVID-19 patients were included into the study. The patients were divided into 3 groups depending on the time elapsed from the onset of the first symptoms to the time when blood samples were collected (from 14 to 500 days). For all samples, the number of S- and N-specific T lymphocytes and the cytokines secreting profiles were determined. Also, the Phenograph automatic clustering algorithm was used to discern different functional groups of the cells.

Approximately 1 in 5 × 103 peripheral blood mononuclear cells was specific for SARS-CoV-2 S-protein, and 1 in 104 was specific for N-protein. Since the first weeks of infection, the number of specific CD8+ cells was significantly higher in COVID-19 patients, as compared with the group of healthy volunteers. As the postinfection period increased, the number of virus-specific CD4+ and CD8+ cells gradually decreased, but remained significantly higher than in control group. Among CD4+ cell population, the proportion of IFNγ-IL- 2-TNFα+ cells decreased and the ratio of IFNγ+IL-2-TNFα- cells increases. During first weeks of the disease, CD8+ lymphocytes are represented predominantly by IFNγ+IL-2-TNFα- cells and IFNγ-IL-2-TNFα+ cells by the end of the observation period. The clustering results showed that, in the early post-infection period, virusspecific T lymphocytes were mostly presented by populations of IFNγ- and TNFα-producing CD4+ effector memory cells. Meanwhile, in later time period, the most common populations were TNFα-producing CD8+ TEMRA and IFNγ-producing CD8+ central memory T lymphocytes.

T cell adaptive immunity plays an important role in the control and elimination of viral infections. In this study, we demonstrated that robust cellular immunity against SARS-CoV-2 is present in the vast majority of patients from the first weeks up to 16 months after the onset of the first symptoms of COVID-19. The immune memory to SARS-CoV-2 is provided by production of central and effector memory T cells, and the data on their time dynamics during the study period allow us to hope for a longer duration of cellular immune memory to SARS-CoV-2.
MicroRNAs as fibrosis markers in patients with hypersensitivity pneumonitis
Authors: Shepelkova G. S. , Zaytseva A. S. , Evstifeev V. V. , Adamovskaya E. N. , Shmelev E. I. , Yeremeev V. V.
Published: April 2024

Hypersensitivity pneumonitis (HP) is a complex interstitial pulmonary syndrome. This clinical entity is characterized by sensitization to a specific antigen. Early detection of this antigen is associated with an increased likelihood of a favorable outcome. Increased mortality in hypersensitivity pneumonitis is associated with the development of lung fibrosis. At the same time, clinical interventions do not significantly improve the prognosis of the disease due to a lack of understanding the mechanisms underlying the development of this type of fibrosis. Using reliable biomarkers that objectively reflect biological processes in lung fibrosis may improve clinical decisionmaking. Various biomarkers are now beginning to play a critical role in diagnosing and treating a variety of human diseases. Unfortunately, hypersensitivity pneumonitis is an exception to this general trend. There is still a great deal of research to be done in this area in the search for diagnostic biomarkers. The aim of this study was to identify biomarkers of lung fibrosis development in patients with hypersensitivity pneumonitis. We used mature serum microRNAs, which may regulate inflammation and fibrosis, as such diagnostic markers. Patients with a diagnosis of hypersensitivity pneumonitis (with and without lung fibrosis) as well as healthy individuals without chronic diseases (control group) were included into the study. Clinical and laboratory parameters were assessed in all patients. The miScript miRNA PCR Array Kit (QIAGEN) was used for gene expression profiling of mature serum miRNAs. The data obtained were verified using real-time PCR. Our research has identified a number of mature microRNAs that are likely to be involved in lung fibrosis and inflammation (miR-22, miR-150 and miR-106b). Following an extended study, including monitoring of disease progression over time, the applied diagnostic kit may be used in clinical practice to determine disease activity and development of fibrosis formation in lung tissue in patients with different variants of hypersensitivity pneumonitis.
Minor population of NK lymphocytes with CD19 coexpression
Authors: Kalashnikova A. A. , Bychkova N. V.
Published: April 2024

Single reports were published concerning a minor subpopulation of NK cells with weak coexpression of the B cell antigen CD19 in the patients’ blood and bone marrow. The frequency and relative number of CD56+CD19+dim cells is virtually not assessed, and there is no data on their phenotypic characteristics, as well as the connection of this subpopulation with any disease state. The purpose of the present study was to assess the frequency, relative quantity and phenotypic characteristics of CD56+CD19+dim lymphocytes in blood of patients referred for assessment of the lymphocyte subpopulation profile. Peripheral blood of immunocompromised individuals was taken, and subpopulation composition of lymphocytes was determined using eight-color flow cytometry (markers: CD3, CD4, CD8, CD19, CD25, CD45, CD56, HLA-DR). To estimate incidence of the CD56+CD19+dim subpopulation, we have carried out a retrospective analysis of LMD files on 1210 studies for 935 patients (average age, 39.8±14.7 years old) including 84 children under 18 years old. The study was performed repeatedly for some patients. Phenotyping of CD56+CD19+dim cells was performed using a panel of antibodies to B cell, T/NK cell antigens. The occurrence of blood samples containing CD56+CD19+dim was 1.2%, with a relative content of 2.1±1.9% among total lymphocyte population (0.8±0.6% of leukocytes). Long-term persistence of the subpopulation was noted in the patients throughout the entire observation period. The comparison of specific marker expression by NK CD56+CD19+dim, and CD56+CD19- cells revealed high expression of CD2, CD57, reduced expression density of CD7, CD16, CD38. The phenotype of the studied NK cell subpopulation was as follows: CD56+dimCD19+dimCD2+brightCD7+dimCD11c+CD16+dimCD38+dimCD45RA+CD57+CD94+dimNKG2D+CD3-CD4-CD5-CD20-CD21-CD25-CD45R0-CD62L-CD79b-CD117-, with variable expression of CD8 and HLA-DR. The phenotype is consistent with activated terminally differentiated adaptive NK associated with cytomegalovirus infection. The individuals with CD56+CD19+dim had a history of CMV-infection and reactivation of chronic EBV-infection at the time of the study. A probable cause of CD19 coexpression may be trogocytosis of B cell membrane fragments by natural killer cells during active EBV-infection. CD56+CD19+dim lymphocytes can reach noticeable values thus altering the results of studies performed by flow cytometry. The errors are most likely to occur upon assessing the minimal residual disease levels in acute B cell leukemias. The minor CD56+CD19+dimNK subpopulation may be detected in routine immunological analysis. Its functional features and association with certain disorders require further studies.
PAULO FREIRE NA FARIA LIMA? CONTRIBUIÇÕES DA PEDAGOGIA CRÍTICA À ALFABETIZAÇÃO FINANCEIRA BRASILEIRA
Authors: Sameer El Khatib Ahmed
Published: April 2024

O objetivo deste artigo é destacar as vozes dos docentes, os profissionais que tomam decisões curriculares, sobre a melhor forma de alfabetização financeira crítica dos seus alunos, suas suposições, pensamentos e experiências. Quatro questões de pesquisa foram formuladas para atingir esse objetivo, sendo a principal: Como a alfabetização financeira crítica, colaborativa e dialógica pode ser facilitada para ajudar os alunos a se tornarem cidadãos críticos à luz das contribuições de Paulo Freire? Exploramos o conceito de alfabetização financeira de diferentes perspectivas e a literatura sobre currículos nacionais estabelecidos para educação financeira provenientes de alguns países do mundo. Em seguida, buscamos subsídios teóricos, para uma melhor compreensão da pedagogia crítica, por meio do diálogo com autores como Paulo Freire, Henry Giroux, Jürgen Habermas, Lev Vygotsky, Peter McLaren, Michael Apple, Antonia Darder e Ira Shor. Os participantes desta pesquisa foram dezesseis docentes do ensino fundamental I e II do estado de São Paulo, que demonstraram aderência às práticas de alfabetização financeira crítica, independentemente da disciplina ministrada. Trata-se de um estudo qualitativo que adota as estratégias de estudo de caso, grupos focais e investigação deliberativa, para examinar as crenças, práticas e histórias de vida e vinhetas narrativas dos participantes. As estruturas desenvolvidas para a alfabetização financeira crítica em termos de habilidades, conhecimentos, estratégias pedagógicas e curriculares necessárias são derivadas do trabalho dos professores em salas de aula e não retiradas de um esquema preconcebido na literatura, o que indica a promoção da cidadania orientada para a justiça social e participativa. Este artigo fornece uma estrutura conceitual dinâmica, desenvolvida para a alfabetização financeira crítica, derivada do trabalho dos docentes e das visões de Paulo Freire, que inclui a tradução da teoria à práxis em consonância com a Pedagogia Crítica.
A Review of the Most Common Injuries in Dancers and Therapeutic Options
Authors: Karnik Riya
Published: April 2024

Sports injuries, including those from dance, are an apparent problem across the United States and United Kingdom with millions of injuries being acquired daily. These injuries can both hinder an individual's day-to-day activities and hamper performances by extending the period of sustained injury and impacting technique. This study details injury prevalence as well as a variety of rehabilitation methods used to treat a specific highly prevalent injury within dance [flexor hallucis longus (FHL) tendinopathy]. The FHL tendon is in the posterior area of the fibula and aids one in conducting plantar flexions. When dysfunction occurs, leading to FHL tendinopathy, this can result in negatively impacting the range of motion in the foot and restricting an individual from many movements. Because FHL tendinopathy is classified as an "overuse" injury, the effects upon an individual such as inflammation and discomfort can worsen the more the tendon is used. By collecting studies detailing impacts upon ballet dancers and sports dancers from varying populations to conduct a systematic review using PubMed, the study can build upon the differences in therapies applied to improve patients’ health after contracting FHL tendinopathy. The study also brings into focus other related conditions such as plantar fasciitis which develops due to straining the plantar fascia ligament. After thoroughly conducting a systematic review, it was determined that conservative management with physical therapy, heel raises, and laser treatment are the most effective in reducing pain as well as shortening the amount of time spent injured.
POLKU 2.0 -työn juurruttaminen ja vaikutusten arviointi
Authors: Kuula Anna-Stina , Ruth-Viitanen Mira , Aaltonen Alisa , Mannila Birgitta , Puurtinen Mikael , Nikkanen Meri , Vallius Elisa
Published: April 2024

POLKU 2.0 -hankkeen toteutus alkoi syksyllä 2021 lähtötilanteen kartoituksella mukana oleville oppilaitoksille. Kartoituksen tavoitteena oli tukea niin hankkeen toteutusta, kuin sen tulosten juurruttamista ja käyttöön jäämistä hankeajan jälkeen. Jälkikäteen voidaan todeta, että lähtökohta-analyysillä on ollut merkittävä rooli hankkeen toteutuksessa sekä sen vaikuttavuudessa. Iloksemme olemme voineet todeta lähtökohta-analyysistä ja työelämäkartoituksesta poikineiden koulutuspilottien toteutusmuotojen herättäneen kiinnostusta eri organisaatioissa niin hankeaikana, kuin jatkokäyttöä ajatellen. Tärkeänä lähtökohtana oli alusta saakka tavoite varmistaa hankkeen tulosten vakiinnuttaminen organisaatioiden toimintaan pitkällä tähtäimellä. Yhtenä juurruttamistyön osa-alueena on ollut mahdollistaa hankkeen aikana tuotetun laajan koulutussisällön sijoittuminen oppilaitoksiin ja pitämään yllä hankeaikaisia yhteiskehittämisen kokemuksia EduFutura-toiminnan kautta. Vastaavasti tavoitteena oli Polkukartta-sivuston jalkauttaminen osaksi TE-palveluiden ja koulutusorganisaatioiden ohjauskäytänteitä. Tässä raportissa käymme läpi hankkeen toteutusta lähtökohdista tuloksiin, keskittyen erityisesti oppilaitosyhteistyöhön, aineistojen juurruttamiseen, työelämäyhteistyöhön sekä oppilaitos- ja urasiirtymien edistämiseen. Pohdimme myös hankkeen toteutusta ja sen arviointia.
APPLYING THE HETEROPHONIC PERSPECTIVE TO ANALYZING MODALITY OF THE VIETNAMESE FRAGMENTS
Authors: Nghi Trinh Quynh Dong
Published: April 2024

The term "heteroglossia" comes from the Russian term "raznorechie," right from the beginning of "heteroglossia," which values the difference of dialogue. This article has applied heterophonic theory to analyze the meaning of Vietnamese fragments in the survey fragment corpus, statistics from 24 short stories collected in Truyện ngắn hay 2019 (multiple authors). The categories “narrowing the dialogue” and “expanding the dialogue” are considered, which makes it possible to believe that the heterophonic approach contributed to the study in identifying isolated groups of sentence modalities. In addition, the article also points out the "unfoundedness" of heterophonic theory in its ability to explain the modality of the fragment.
TERMINOLOGY OF KINSHIP IN THE TOPONYMS OF THE SOUTHERN REGIONS OF RUSSIA
Authors: Fayzieva Galina , Gromova Natal'ya
Published: April 2024

The authors of the article investigate the process of fixing kinship terms in geographical names of the Astrakhan, Volgograd, Rostov regions and the Krasnodar Krai. Toponyms formed from kinship terms are considered as a special category of words reflecting historical, linguistic and social load. In the course of the study, the authors analyzed more than 6 thousand toponyms, 498 of them are geographical names of the Astrakhan region, 1567 of the Volgograd region, 2374 of the Rostov Region and 1897 of the Krasnodar Krai. The sampling was carried out according to three classes of toponyms (oikonyms, astyonyms and hydronyms), selected by a continuous sampling method from regional toponymic dictionaries, dictionaries of geographical names of Russia and on the official websites of designated subjects of the Russian Federation.

The general direction of the research is to study the main directions of extrapolation of kinship terms, in connection with which the purpose of this work is to determine the presence of kinship terms among regional toponyms as a reflection of the "family" and "spatial" codes inherent in the linguistic picture of the world of the native Russian people. The novelty of the work lies in the proof of the typological nature of kinship terms, presented by the example of regional toponyms. The study was conducted using descriptive and comparative methods.
The potential influence of Sustainable Development Goal 6.1 in the South African legislative context
Authors: Kasker Muhammad Sameer
Published: April 2024

Water is at the very core of sustainable development, as it is critical for a thriving people and planet. However, limited water access has for long plagued many parts of the world, South Africa included. In recent years, there have been increasingly urgent warnings of a global water crisis because humanity consistently uses more safe water than is sustainably available. From an international perspective, the most recent development dealing with water access, conservation and management is Sustainable Development Goal 6 (SDG 6), which forms part of the 2030 Agenda for Sustainable Development. SDG 6 covers the entire water cycle, including the management of water, wastewater and ecosystem resources, and places water at the centre of sustainable development. This critical goal can be achieved if it is properly pursued in national settings. Thus, this article focuses on the domestic implementation of SDG 6.1 against the backdrop of current South African legislation dealing with water access and management. The aim of the article is to analyse SDG 6.1 and determine if and how it can be incorporated into South African water legislation in order to give effect to it and grant it legal legitimacy in the domestic context.
The prevalence of cybercrimes and hacking incidents and their impact on the confidentiality of documents in civil proceedings
Authors: Mabeka Nombulelo Queen
Published: April 2024

Confidentiality is important in legal practice as it obligates legal practitioners to protect clients' information. It is often linked to the right to privacy entrenched in section 14 of the Constitution of the Republic of South Africa, 1996. The link is made on the basis of clients' entitlement to attorney-client confidentiality. Furthermore, the rules of courts in civil proceedings require legal practitioners to include clients' personal or confidential information in court documents, including their identity numbers. The requirement of clients' personal information in court documents is found in particular in Rule 3(A)(1)(b)(i) of the Uniform Rules of Court, 2009 as amended. This personal information is uploaded online in the CaseLines system, as required by Practice Direction 1 of 2023, a situation which poses a significant risk because such information may be hacked and used to commit cybercrimes. Current legislation, such as the Protection of Personal Information Act 4 of 2013, seeks to provide guidelines on how courts should protect confidential information which is included in the pleadings or affidavits. The Practice Directives, however, are silent on measures that should be taken to protect confidential information. Item 18 of the E-Rules and the Draft Amended Magistrates' Courts Rules seek to protect confidential information to a certain extent, but these have not yet been implemented. The article examines current legislation, the respective rules of court, and the approach followed by the courts, in order to determine whether confidentiality does indeed exist in civil proceedings. In addition, it briefly compares the online civil proceedings of South Africa and the United Kingdom to ascertain their differences and similarities.
Povijest rane i klasične teorije filma
Authors: Lučić Krunoslav
Published: April 2024

Knjiga Povijest rane i klasične teorije filma fokusira se na analizu i tumačenje relevantnih pristupa filmskome mediju i umjetnosti od njezinog ranog razdoblja krajem 19. i početkom 20. stoljeća, pokušaja formuliranja cjelovitih teorija sredine 1910-ih, preko avangardnih strujanja u 1920-ima pa sve do završnih faza tzv. klasičnog razdoblja filmske teorije početkom 1960-ih kada je pod utjecajem novonastalih semiotičkih i strukturalističkih metodologija razumijevanje filma dobilo neke nove, modernije obrise. Glavni je cilj knjige ponuditi analitički uvid u povijesni aspekt razumijevanja filmske umjetnosti te načina kako je određeni tip filmske teorije utjecao na konkretnu filmsku praksu proučavanog razdoblja, ali i kako je ta praksa rukovodila središnjim postavkama određene teorije. U tom kontekstu knjiga se fokusira na relevantne autore klasične teorije filma, poput R. Canuda, G. Dulac, L. Delluca, J. Epsteina, V. Lindsayja, H. Münsterberga, S. Ejzenštejna, R. Arnheima, A. Bazina, S. Kracauera,, odnosno na pretpovijest filmske teorije do shvaćanja filma kao umjetničkog fenomena, na ranu nijemu filmsku teoriju francuskih autora vizualističke orijentacije i pokušaj afirmiranja filma kao umjetnosti, (rusko) formalističku i konstruktivističku teoriju sovjetske montažne škole, općenito formativne, ali i realističke tendencije u poslijeratnom razumijevanju filma, kao i na psihologijski inspirirane pristupe pojedinih klasičnih teoretičara.
ЭМПИРИЧЕСКИЕ ИССЛЕДОВАНИЯ ЗАКУПОК ГОРМОНАЛЬНЫХ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ В МЕДИЦИНСКОЙ ОРГАНИЗАЦИИ В ПЕРИОД ПАНДЕМИИ СОУГО-19
Authors:   Воронежский государственный университет, ЕРИГОВА О.А. , ЮСУПОВА Ю.В. , ЧУПАНДИНА Е.Е.
Published: April 2024

Для лечения новой короновирусной инфекции COVID-19 в стационарных условиях применяется и гормональная терапия лекарственными препаратами Дексаметазон и Преднизолон. Цель исследования - исследование закупок медицинской организации гормональных лекарственных препаратов для оказания стационарной медицинской помощи пациентам с COVID-19. Объемы закупок Преднизолона имеют тенденцию к снижению за период 2020 - 2022 года. Объем закупок Дексаметазона носит волнообразный характер, с трендом на общее снижение. Анализ изменения цен за исследуемый период показал увеличение цены для данных лекарственных препаратов. Падение показателей объемов закупок гормональных лекарственных препаратов для лечения COVID-19 нивелируется ростом цен.
АНАЛИЗ КОНКУРЕНТНЫХ ПРЕИМУЩЕСТВ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ ОТЕЧЕСТВЕННОГО И ИМПОРТНОГО ПРОИЗВОДСТВА
Authors:   Белгородский государственный национальный исследовательский университет, КОЛЕСНИКОВ А.С. , МАЛЬЦЕВ Е.А. , ХУССЕЙН М.А.
Published: April 2024

На основании статистических данных и результатов анкетирования населения проведен анализ конкурентных преимуществ отечественных и импортных лекарственных препаратов. Установлено, что основным конкурентным преимущество отечественных лекарств является их стоимость.
ФАРМАЦЕВТИЧЕСКАЯ ОТРАСЛЬ: АНАЛИЗ ПОТРЕБЛЕНИЯ И ОПТИМИЗАЦИЯ ОБЕСПЕЧЕНИЯ НАСЕЛЕНИЯ ЛЕКАРСТВЕННЫМИ СРЕДСТВАМИ НА РЕГИОНАЛЬНОМ УРОВНЕ
Authors:   Орловский государственный университет имени И. С. Тургенева, САМОЩЕНКОВА И.Ф. , КОНДРАТОВА Д.В. , ЦЫГАНОВ В.С. , ГАРАНКИНА Р.Ю. ,   Первый Московский государственный медицинский университет имени И.М. Сеченова
Published: April 2024

В июле 2023 года распоряжением Правительства РФ №1495-р была утверждена Стратегия развития фармацевтической промышленности «Фарма-2030» — карта стратегического развития фармацевтической отрасли, а система здравоохранения - главный адресат всей деятельности этой отрасли. Целью исследования являлось изучение потребления и оптимизации механизмов обеспечения населения лекарственными средствами на региональном уровне, на примере Орловской области.