bluuebunny/crossref_metadata_2025 huggingface dataset:
A VIOLÊNCIA DE GÊNERO NOS CONTOS DE FADAS: ATRIBUTOS PARA PENSAR A(S) INFÂNCIA(S) E A EDUCAÇÃO NA CONTEMPORANEIDADE
Authors: De Souza Ravelli Henrique , Furlan de Oliveira Marta Regina
Published: October 2021

De maneira ampla, este texto objetiva analisar as relações de poder por meio da violência de gênero nos contos de fadas e, possíveis liames no contexto da educação da (s) infância (s) contemporânea (s). De modo particular, refletir sobre os discursos utilizados nos contos dos Irmãos Grimm (2018), principalmente os de: Chapeuzinho Vermelho; A Bela Adormecida; Branca de Neve e Gata Borralheira a fim de melhor compreender como os mesmos são arqueologicamente formados pelas relações de poder. A metodologia é um estudo bibliográfico em Bettelheim (2018); Andrade (2015); Filha (2011) e autores que dialogam com as teorias sobre os contos dos Irmãos Grimm e, ainda, análise interpretativa dos personagens femininos protagonistas e antagonistas dos contos literários de fadas e suas articulações com os estudos de representações sociais. Os contos, quando não questionados, tornam-se reprodutores da violência de gênero nos corpos humanos desde a infância, visto que, há várias formas de ser e se portar em relação às subjetividades. Os resultados apontam para a necessidade de um trabalho crítico e interativo sobre os contos literários, principalmente, no que se refere ao processo de formação da(s) infância(s) e seu processo educativo. Por meio dos contos supracitados há a possibilidade de desenvolver a (des) construção e (re)posição dos padrões normativos por mediação do trabalho pedagógico docente dirigido às crianças e suas subjetividades humanas.
OS JOGOS E AS BRINCADEIRAS NO PROCESSO DE ALFABETIZAÇÃO: UM ESTUDO SOBRE A PERCEPÇÃO DE PROFESSORAS DOS ANOS INICIAIS
Authors: Silva Scheffer Amanda , Volpato Gildo
Published: October 2021

RESUMO: A presente pesquisa teve como objetivo geral compreender como os jogos e as brincadeiras são concebidos pelas professoras que atuam no processo de alfabetização e letramento das crianças nos dois primeiros anos dos Anos Iniciais do Ensino Fundamental. Tem como objetivos específicos: identificar quais são os jogos utilizados pelas professoras no processo de alfabetização e por que razão e observar como os jogos e brincadeiras são utilizados nos Anos Iniciais do Ensino Fundamental, a partir de entrevista semiestruturada com seis professoras. Dessa forma, caracterizou-se como uma pesquisa de campo, de natureza básica e abordagem qualitativa. Para o referencial teórico, utilizou-se autores como Volpato (2017), Kishimoto (2016), Vygotsky (1994), entre outros pesquisadores da área. Foi possível compreender que na percepção das entrevistadas o jogo e brincadeira são importantes como suporte pedagógico no processo de alfabetização e letramento das crianças, porém algumas delas ainda atribuem seu valor ao descanso, recreio ou como descarga de energia acumulada, se aproximando de concepções clássicas já superadas. Afirmaram que percebem que quando incluem o jogo no processo de alfabetização se torna mais prazeroso, mais dinâmico, há maior interesse dos estudantes pelo conteúdo e facilita a aprendizagem, pois torna-a mais significativa.PALAVRAS CHAVE: Jogos. Brincadeiras. Ensino Fundamental. Professoras.
A ALFABETIZAÇÃO NA EDUCAÇÃO INFANTIL E OS DIREITOS DE APRENDIZAGEM E DESENVOLVIMENTO PROPOSTOS PELA BNCC
Authors: Ferrari Westrup Beatriz , Camargo Gislene
Published: October 2021

RESUMO: O presente artigo tem como foco principal compreender o processo de alfabetização na Educação Infantil com crianças pequenas e sua relação com os direitos de aprendizagem e desenvolvimento da BNCC. Assim os objetivos específicos são: Conhecer as orientações sobre alfabetização na Educação Infantil propostas pela BNCC; Compreender os direitos de aprendizagem e desenvolvimento da BNCC; Identificar menções à alfabetização, nos documentos que norteiam a Educação Infantil; Averiguar práticas pedagógicas de alfabetização na Educação Infantil. Para a construção do referencial teórico foram utilizados autores e os principais documentos que norteiam a Educação Infantil como: BNCC (2017), RCNEI (1998), DCNEI (2010), Santa Catarina (2019), Mello (2009), Britto (2005), entre outros. A pesquisa teve caráter bibliográfico. Assim, identificou-se que os documentos não fazem menção a alfabetização na Educação Infantil, mas sim a importância de valorizar as experiências e vivências que acontecem nesse segmento, principalmente o brincar e o explorar. Concluiu-se que alfabetização deve acontecer apenas no Ensino Fundamental, mas durante a Educação Infantil a criança pode ter contato com a linguagem escrita, por meio de ambientes alfabetizadores e diferentes experiências, e que a mesma seja protagonista nesse processo de construção.PALAVRAS CHAVE: Educação Infantil. Alfabetização. Direitos de aprendizagem-BNCC.
AUTOAVALIAÇÃO DE COMPETÊNCIAS DIGITAIS DE PEDAGOGAS DE UMA ESCOLA DE CRICIÚMA/SC
Authors: Pereira Albuquerque Christie , Gonçalves Leila Laís
Published: October 2021

RESUMO: A fluência do professor no uso das tecnologias digitais de comunicação e informação (TDIC) é temática recorrente em pesquisas e que tomou contornos muito particulares por conta da pandemia da COVID-19. Com o Ensino Remoto Emergencial, formato que possibilitou a continuidade da educação e mudou a prática dos professores, as competências digitais se tornaram essenciais para o trabalho docente. Diante disso, a pesquisa buscou analisar o nível de apropriação de competência digital de pedagogas do ensino fundamental anos iniciais de uma escola da rede municipal de Criciúma/SC. A opção metodológica adotada foi a pesquisa descritiva, bibliográfica e estudo de campo com abordagem quantitativa. O estudo abordou as TDIC e sua aplicação na educação, as competências digitais dos professores e a sua autoavaliação apontando instrumentos para autoavaliação. A pesquisa foi aplicada em uma escola da rede municipal de Criciúma/SC envolvendo oito pedagogas. Foi utilizado, como instrumento de autoavaliação, o Guia EduTec do Cieb. A partir da descrição do cenário pesquisado e a interpretação dos resultados pôde-se concluir que, de forma geral, os professores usam pontualmente as tecnologias como apoio ao ensino, caracterizando a apropriação como nível de familiarização. Com os resultados da pesquisa espera-se contribuir na reflexão sobre a apropriação para o uso de TDIC na prática pedagógica e com informações para o planejamento de jornadas formativas mais efetivas envolvendo os recursos tecnológicos.PALAVRAS-CHAVE: Competências Digitais do Professor. Avaliação de Competências Digitais. Instrumento de autoavaliação. Tecnologia Digital de Informação e Comunicação.
AS CONTRIBUIÇÕES DAS METODOLOGIAS PARA O PROCESSO ENSINO-APRENDIZAGEM DOS ALUNOS DA EDUCAÇÃO BÁSICA – ANOS INICIAIS
Authors: Kammer Jaqueline , De Bittencourt Ricardo Luiz
Published: October 2021

RESUMO: A educação escolar está em constante mudança, aperfeiçoando seus métodos pedagógicos. Por este motivo as metodologias utilizadas em sala devem ser analisadas e repensadas, para verificar se as mesmas estão suprindo as necessidades educacionais. A pesquisa tem por objetivo geral “analisar como as metodologias utilizadas pelos professores contribuem para a melhoria do processo ensino-aprendizagem dos alunos do Ensino Fundamental I”. A pesquisa traz como principais autores para fundamentar o assunto abordado Mizukami (1986) para conceituar as metodologias nas abordagens de ensino e Libâneo (2014) com as tendências pedagógicas. Desenvolveu-se a coleta de dados por meio de entrevista semiestruturadas, com seis professoras que atuam na rede municipal de Forquilhinha/SC, nas turmas de 1º e 5º ano dos anos iniciais. Com o desenvolvimento da pesquisa, conclui-se que as metodologias utilizadas pelas professoras contribuem para a aprendizagem de seus alunos de forma a torná-los sujeitos ativos na sociedade. Percebeu-se também que as entrevistadas se encontram em constante aprendizado, em busca de novos meios e conhecimentos para atender de maneira eficaz e eficiente seus alunos. Embora algumas atuam na rede há muito tempo possuem um olhar atual sobre o ensino, buscando sempre meios diversificados para levar aos seus alunos o melhor em material didático.PALAVRAS CHAVE: Metodologia; Ensino-aprendizagem; Formação de Professores.
ENTRE A “NÃO AULA” E A AULA NA EDUCAÇÃO FÍSICA: CARACTERIZAÇÕES NECESSÁRIAS
Authors: De Menech Leandro , Cardoso Ana Lucia
Published: October 2021

Resumo: Essa pesquisa teve como centralidade, compreender as características da não aula de Educação Física escolar, mediante os estudos publicados acerca desta temática. Nesse sentido desenvolvemos uma pesquisa bibliográfica, tendo como problema a seguinte interrogação: quais as caracterizações necessárias da “não aula” na Educação Física? Elencamos como objetivos específicos: Identificar a produção de conhecimento sobre as “não aulas” de Educação Física; Explicitar as características da aula e da “não aula” de Educação Física. Os autores que nos debruçamos foram Santos et al. (2006), González et al. (2009), Machado et al. (2010) e Coletivo de Autores (2009). Concluímos que o fenômeno nomeado como “não aula” apresenta algumas denominações distintas, no entanto após estudos mais aguçados acerca dos autores identificamos muitas semelhanças e sobreposição entre as denominações, como a ausência de uma intencionalidade pedagógica, o abandono com a qualidade do trabalho docente e o professor como um mero distribuidor de material pedagógico.Palavras-chave: Não aulas. Educação Física. Aulas.
AS PRÁTICAS DE ALFABETIZAÇÃO NA EJA NA VISÃO DAS PROFESSORAS DOS ANOS INICIAIS DO ENSINO FUNDAMENTAL EM UM MUNICÍPIO DA AMREC
Authors: Custódio Sibele Guedin , Volpato Hanoff Mirozete Iolanda
Published: October 2021

A presente pesquisa tem como objetivo geral conhecer as metodologias que embasam as práticas pedagógicas das professoras alfabetizadoras na Educação de Jovens e Adultos (EJA) em um município pertencente a região da AMREC3. A alfabetização no Brasil, nos anos iniciais do ensino fundamental e na EJA, durante muitos anos aconteceu seguindo a concepção tradicional de ensino e aprendizagem, ou seja, iniciava com as letras do alfabeto e palavras soltas e sem sentido para os alunos. Entretanto, há mais de duas décadas os estudiosos sobre o tema no Brasil têm mostrado que existem outros métodos para alfabetizar e que devem ser utilizados em ambas modalidades e que atendem mais as necessidades da sociedade e tem mais significado para os alunos. Diante desse contexto buscou-se, também, identificar a concepção pedagógica que embasa a prática das professoras, refletir sobre o perfil do professor e do aluno nesta modalidade e analisar as metodologias utilizadas pelas professoras da EJA no processo de alfabetização. Para isso, a pesquisa está sustentada em autores como: Freire (1990), Schwartz (2010), Cortada (2013), Haddad e Di Pierro (2000) e Leal (2010). A pesquisa é exploratória descritiva e de natureza básica, em que foram entrevistadas duas professoras da EJA do município, que atuam nos anos iniciais. A entrevista aconteceu de forma não estruturada. A pesquisa aponta que mesmo as metodologias utilizadas sejam distintas, as professoras buscam em alguns momentos considerar as práticas de letramento dos seus alunos no processo de alfabetização.
Logopedia a metodologia badań nauk społecznych
Authors: Hamerlińska‑Latecka Agnieszka
Published: October 2021

The present text is an attempt to connect the speech therapy with the research methodology of the social science. In it an outline of the research and described strategies of quality inspections were presented and quantitative which can be taken in this area. The author made characteristics of chosen research methods as well as is emphasizing the weight of ethics of examinations in the speech therapy.
Jakość mowy zastępczej u chorych po usunięciu krtani bez protezy głosowej i z wszczepioną protezą głosową typu Provox II
Authors: Olszewski Jurek , Owczarek Kalina
Published: October 2021

Introduction. The quality of substitute speech with laryngectomees patients with or without the implanted voice prosthesis type Provox II on the bases of two clinical cases was compared. Material and methods. The evaluation of voice was compared on the bases of two patients treated in Otolaryngological and Laryngological Oncology Clinic. The patients K.P. aged 46 (medical history number 2778/2008) who, on March 12, 2008 underwent total laryngectomy with the Rethie method including the removal of left thyroid lobe due to thyroid and larynx cancer. The patients D.K. ages 44 (medical history number 13705/2010) who on November 4, 2010 underwent total laryngectomy with the Rethie method including selective lymphe node operation of Region II on the right side with the implanting of the voice prosthesis type Provox II due to larynx cancer. Each patients was instructed on tracheostomy care and systematic performing of the fallowing exercises: diaphragmatic‑ribbed tract breathing loosening masseter muscle system and esophageal sphincter, the use of lauder reflection in the process of voice production, the method of obtaining loud reflection lengthening of the time of phonation and eliminating breath sounds. The evaluation of the quality of substitutive speech was performed after three months. Results. On the basis of the conversation with the patients, it turned out that the patient with the implanted voice prosthesis had better quality of substitutive speech and better communication possibility. Conclusions. The learned substitutive speech with the interoperatively implanted the voice prosthesis type P. II turned out to be the best way of communication.
César Vallejo: la prosa poética de algunos artículos periodísticos
Authors: Huárag Eduardo
Published: October 2021

Estudio de algunas crónicas periodísticas (1924-1929) de César Vallejo que, luego de algunas modificaciones sustantivas, se convierten en prosa poética. Ciertamente, se produce una especie de vaso comunicante entre la crónica y el relato literario. Se aborda el mismo tema e incidente, y mientras en un caso prevalece la información periodística, en el otro modifica la expresión verbal y lo somete a las exigencias propias del relato literario. En este estudio se agrega, además, el análisis de dos textos de prosa poética que no tienen antecedentes en artículos periodísticos. Como se verá, se trata de un proceso de búsqueda en el que el poeta y narrador va definiendo su estilo, su prosa y su ideario ideológico.
La ficcionalización de la independencia en dos novelas escritas durante las celebraciones del primer centenario
Authors: Pollarolo Giovanna
Published: October 2021

Como parte de las celebraciones de 1921-1924, el gobierno del presidente Leguía convocó el Concurso del Centenario de la Batalla de Ayacucho en las áreas de poesía y novela. Tiempos de la patria vieja. Novela histórica de Angélica Palma (Lima, 1878-1935) y Por la estirpe. Novela colonial de José Félix de la Puente (Trujillo, 1882-1959) fueron las ganadoras. Prestando atención al relato de ciertos hechos, personajes y la trama amorosa, en este trabajo analizo las representaciones discursivas del proceso independentista que construyeron ambas novelas después de los primeros cien años de declarada la independencia. Me interesa mostrar cómo, a contracorriente de la historia oficial, esas novelas dan cuenta de la memoria de la independencia como una guerra civil, dolorosa y desgarrada.
De la palabra a la imagen: las versiones cinematográficas de A esmorga
Authors: Puíme Sabugueiro Montserrat
Published: October 2021

El propósito de este artículo es realizar una comparación entre la obra literaria de Eduardo Blanco Amor, A esmorga, y los filmes Parranda, del director Gonzalo Suárez, y A esmorga, del cineasta Ignacio Vilar. Se intenta realizar un ejercicio de literatura comparada, donde la metodología predominante es la empleada en el estudio de las relaciones interartísticas, más concretamente entre la literatura y el cine. Para realizar el análisis comparativo, se estudia elementos como el tiempo, el espacio, narradores, los personajes, la crítica cinematográfica, entre otros. Finalmente, los resultados encontrados son dispares, muy significativos en dichas películas, aunque la esencia siga siendo la misma, debido a la influencia del hipotexto.
Exploratory Analysis into the in vitro and in silico Activity of E. fusca Lour. (Fabaceae) Elucidates Substantial Antiplasmodial Activity of the Plant
Authors: Sazed Saiful Arefeen , Islam Ohedul , Bliese Sarah L. , Hossainey Muhammad Riadul Haque , Shawon Jakaria , Mahmud Araf , Soma Mahfuza Afroz , Rashid Mohammad Abdur , Rahman Mohammad Sharifur , Ghosh Prakash , Alam Mohammad Shafiul
Published: October 2021

The exploration of alternative antimalarial therapeutics is a requisite for the emergence of resistance against Artemisinin. Considering the required cost and time length of classical small molecule drug discovery process, phytochemical screening of traditionally used medicinal plant which are repertoire of active compounds with antimalarial activity has become popular. To investigate the antimalarial property of traditionally used medicinal plants, a number of Erythrina spp have been reviewed systematically where less studied E. fusca has been selected for further analysis. Phytochemical investigation yielded five compounds namely; Phaseolin, Phytol, β-amyrin, Lupeol, and Stigmasterol. In-vitro antimalarial drug sensitivity HRP-II ELISA was carried out against chloroquine (CQ) sensitive 3D7 and CQ-resistant Dd2 strains. Extracts showed significant antimalarial activity against 3D7 and Dd2 strains (IC50 4.94 – 22 µg/mL) and these compounds have been reported here for the first time. Molecular docking analysis showed high binding energy (−9.0 ± 0.32 kcal/mole) indicating high degree of interaction between Phaseolin and 14 clinically important Plasmodium falciparum proteins at the active site. Stable interaction was also observed between ligand and protein from molecular dynamics simulation analysis with high free energy (−75.156 ± 11.459) that substantiates the potential of Phaseolin as an antimalarial drug candidate.
Groundwater Resources Management Modelling: A Review
Authors: Aderemi Banjo Ayoade , Olwal Thomas Otieno , Ndambuki Julius Musyoka , Rwanga Sophiar S
Published: October 2021

Globally, groundwater is the largest distributed storage of freshwater that plays an important role in an ecosystem’s sustainability in addition to aiding human adaptation to both climatic change and variability. However, groundwater resources are dynamic and often changes as a result of land usage, abstraction as well as variation in climate. Thus, efficient management of groundwater resources to prevent overexploitation, scarcity, and minimising the effects of drought has become a major challenge for researchers as well as water managers. Furthermore, a number of research challenges such as the lack of computational efficiency and scalability due to uncertainties from input parameters to the groundwater resource model have been revealed in the management of groundwater resources. To solve these challenges, many conventional solutions such as numerical techniques have been proffered for groundwater modelling. Also, the use of data-driven techniques such as machine learning is gaining more attraction to solve these aforementioned challenges. Thus, this has made efficient data gathering essential to maintain da-ta-driven groundwater resources management models from the observation site. The global evolution of the Internet of Things (IoTs), has increased the nature of data gathering for the management of groundwater resources. In addition, efficient data-driven groundwater resource management relies hugely on information relating to changes in groundwater resources as well as their availability. Although the IoTs enabled automated data processing systems are in existence by transmitting the generated data from IoT enabled devices into the cloud through the Internet. However, traditional IoT Internet is not scalable and efficient enough to process the generated vast IoT data At the moment, some pieces of the literature revealed the groundwater managers lack an efficient, scalable and real-time groundwater management system to gather the required data. Also, the literature revealed that the existing methods of collecting data lack efficiency to meet computational model requirements and meet management objectives. Thus, it is necessary to have an efficient and scalable IoT system to extract valuable information in real-time for groundwater resource management. Unlike previous surveys which solely focussed on particular groundwater issues related to simulation and optimisation management methods, nonetheless, this paper seeks to highlight the current groundwater management models as well as the IoT contributions
Innovative Energy-Saving Propulsion System for Low-Speed Biomimetic Underwater Vehicles
Authors: Piskur Paweł , Szymak Piotr , Przybylski Michal , Naus Krzysztof , Jaskólski Krzysztof , Zokowski Mariusz
Published: October 2021

This paper describes research on a unique propulsion system design for a low-speed Biomimetic Unmanned Underwater Vehicle (BUUV). It is biomimetic in the sense that it mimics the movement of aquatic organisms. The undulating propulsion system has numerous advantages over the rotary impeller and is becoming more popular in underwater robotics. The analysis of an artificial seal’s propulsion system with two tail fins is described here. The contrast between the previous undulating propulsion system and the new one is detailed using mathematical analysis and experimental data. The experimental comparison was carried out on a laboratory test stand equipped with specialist sensor equipment to determine the energy efficiency of various types of propulsion systems. Due to a patent procedure, the innovative propulsion system presented in this work has never been published previously. The fins have extra joints, which is the subject of patent claims. The extra joint is intended to improve energy efficiency and reduce fatigue wear on the fins.
Cybersecurity in the Internet of Things in Industrial Management
Authors: Raimundo Ricardo , Rosário Albérico Travassos
Published: October 2021

Nowadays, people live amidst the smart home domain, business opportunities in the industrial smart city and health care, though, along with concerns about security. Security is central for IoT systems to protect sensitive data and infrastructure, whilst security issues become increasingly expensive, in particular in Industrial Internet of Things (IIoT) domains. Nonetheless, there are some key challenges for dealing with those security issues in IoT domains: Applications operate in distributed environments such as Blockchain, varied smart objects are used, and sensors are limited in what comes to machine resources. In this way, traditional security does not fit in IoT systems. In this vein, the issue of cyber security has become paramount to the Internet of Things (IoT) and Industrial Internet of Things (IIoT) in mitigating cyber security risk for organizations and end users. New cyber security technologies / applications present improvements for IoT security management. Nevertheless, there is a gap on the effectiveness of IoT cyber risk solutions. This review article discusses the, trends around opportunities and threats in cyber security for IIoT.
Study on Significant Drift in the Domain of Explainable Artificial Intelligence
Authors: Chauhan Tavishee , Palivela Hemant
Published: October 2021

Artificial Intelligence (AI) is required since multiple resources are in need to complete depending on a daily basis. As a result, automating routine tasks is an excellent idea. This reduces the foundation's work schedules while also improving efficiency. Furthermore, the business can obtain talented personnel for the business strategy through Artificial Intelligence. Explainability in XAI derives from a combination of strategies that improve machine learning models' environmental flexibility and interpretability. When Artificial Intelligence is trained with a large number of variables to which we apply alterations, the entire processing is turned into a black box model which is in turn difficult to understand. The data for this research's quantitative analysis is gathered from the IEEE, Web of Science, and Scopus databases. This study looked at a variety of fields engaged in the (Explainable Artificial Intelligence) XAI trend, as well as the most commonly employed techniques in domain of XAI, the location from which these studies were conducted, the year-by-year publishing trend, and the most frequently occurring keywords in the abstract. Ultimately, the quantitative review reveals that employing Explainable Artificial Intelligence or XAI methodologies, there is plenty of opportunity for more research in this field.
A Ten-Week Motor Skills Training Program Increases Motor Coordination in Children with Developmental Coordination Disorder
Authors: Orifjon Saidmamatov , Raximov Quvondiq , Rodrigues Paula , Vasconcelos Olga
Published: October 2021

The present study aimed to investigate the effect of a motor skills training program in children with DCD considering their gender. The Movement Assessment Battery for Children (MABC-2) classified the children and assessed skill changes over time. The study was implemented at four kindergartens in the Khorezm region of Uzbekistan. In the study, all children had DCD (5.17 ± 0.70 years; 10 girls), and all indicators on MABC-2 were less than 16 percent. Participants were divided into an experimental group (n=17) receiving ten weeks of motor skills training program for 45 min twice per week, the control group (n=7) proceeded with exercises of everyday living. All children in the experimental group had a significant increase in total percentile rank of MABC-2 and concerning each domain (manual dexterity; throwing and catching; balance). In the control group, a significant decrease in the total percentile rank of MABC-2 and each domain of MABC-2 was observed. The effectiveness of the intervention program was similar across both genders. The study supports that a period of 10 weeks of a motor skills training program can increase the quality of children's motor coordination and represent a valuable procedure for physical education specialists to enhance motor skills for children with DCD.
The Relevance between Iodine Nutritional Status and BRAFV600E Mutation on Papillary Thyroid Cancer
Authors: Lin Yan-Yu , Hsieh Yu-Shan
Published: October 2021

Papillary thyroid carcinoma (PTC) accounts for approximately 85%-90% of all thyroid cancers. BRAFV600E mutation is a highly specific target for papillary thyroid carcinoma (PTC) and may have a reciprocal causative relationship with iodide-metabolizing genes. Here, we performed a review of studies published in the past 10 years to determine the relationship between iodine intake and BRAFV600E mutation in patients with PTC. We searched the MEDLINE, PubMed, and EMBASE databases for studies published from 2009 to 2019; seven partially matched the selection criteria and were suitable for review, and five passed all selection criteria. We divided the patients into three groups by iodine intake: low (urinary iodine concentration [UIC] <100 μg/L), adequate (UIC 100–200 μg/L), and high iodine intake groups (UIC ≥200 μg/L). Between-group analysis revealed no significant differences in the odds ratio of the prevalence of BRAFV600E mutation between the high and adequate/low iodine intake groups and between the adequate and low iodine intake groups. To further analyzed the results of studies, they exhibited U-shaped curves in the relation of deficient and excessive dietary iodine intake in BRAFV600E mutation. The results might suggest that iodine intake slightly influences the prevalence of BRAFV600E mutation in patients with PTC despite the heterogeneity of studies. Further research should explore potential mechanisms underlying the associations between iodine intake and BRAF mutation in PTC. The systematic review was registered in PROSPERO (CRD42021279462).
gp120 Alters Its Conformation to Enhance Evasiveness and Infectivity
Authors: Ayariga Joseph A. , Gildea Logan , Ipimoroti Ayodeji , Matthews Qiana L.
Published: October 2021

Infection by human immunodeficiency virus type I (HIV-1) requires virus particle binding to host cell-surface receptor CD4 via the viral envelope glycoprotein gp120. HIV-1 therapy and prevention efforts involve development of mimetic or recombinant gp120 vaccines or deployment of antiviral agents that target specific epitopes of gp120. The unliganded conformational state of gp120 is closed, whereas the CD4-bound state is open. However, in between, there exist dynamic conformational states, indicating intrinsically flexible region(s) of structural dynamics, imposing a structural challenge for developing drug or antibody targets. Known conformational states of gp120 were determined by X-ray crystallographic and cryo-electron microscopy, and neither method captures the population of gp120 species arising from conformational plasticity, motions, and transitions. gp120 plasticity brings up several important questions. How will differences in conformation affect receptor binding, antibody recognition, and neutralization? Which regions are crucial for gp120 structural plasticity? How could structural dynamics influence HIV-1 evasiveness against host immunity and drugs or vaccines, and facilitate the viral entry into its host? This review explores the structural constraints presented by conformational states of the glycoprotein to antibodies or drugs and how these conformational states provide structural avenues for the virus to escape neutralizing agents and evade host immunity.
Unveiling the Actual Progress of Digital Building Permit: Getting Awareness through a Critical State of the Art Review
Authors: Noardo Francesca , Guler Dogus , Fauth Judith , Malacarne Giada , Mastrolembo Ventura Silvia , Azenha Miguel , Olsson Per-Ola , Senger Lennart
Published: October 2021

Growing interest is awarded to the digitalization of the building permitting use case and many works are developed about the topic. However, the subject is very complex and many aspects are usually tackled separately, making it very hard for traditional literature reviews to grasp the actual progress in the overall topic. This paper unveils the detailed state of the art in Digital Building Permitting (DBP) by critically analyzing the literature by means of a set of coding tags (research progress, implementation, affected DBP workflow steps, ambitions addressed) assigned by a multidisciplinary team. The mainly addressed aspects of the digitalization of building permits resulted to be the technologies to check the compliance of design proposals against regulations, followed by the digitalization of regulations. Lacking aspects are instead the involvement of officers, scalability of solutions and interoperability of data, intended both as data validation and as integration of geoinformation with building models.
Similarities between Hurricanes and Galaxies: A Short Review
Authors: Henry Jim , Yurukcu Mesut , Nnanna George
Published: October 2021

Universe created with the fundamental laws of science. Nature is lazy and needs to form with the least possible to be perfect. A natural pattern, such as pinecones, sunflowers, pineapples, and cacti, has a double spiral structure. Once we look at these plants' centers, we will see the seeds line up in spirals shape. The number of spirals whirling in each direction will give us the Fibonacci numbers. We can give more examples representing these natural patterns; however, one example is unique and remarkable. The similarities between spiral galaxies- Milky Way and hurricanes. Are they similar in every property or just in shape and rotational movements? What are the similarities between them? This short review article will try to find these questions' answers by reviewing some literature articles. The first part of this article gave some information about hurricanes and galaxies. The second of this article focused on the comparison between hurricanes and galaxies. Finally, we will conclude the article with our remarks.
Telomerase Gene Therapy: A Remission Towards Cancer
Authors: Quazi Sameer
Published: October 2021

Telomerase is an enzyme which is culpable for the aliment and stability of telomeres. It also maintains the genomic integrity and chromosomal stability. The progressive shortening of telomeres may cause chromosomal instability and alternation in the telomerase. It may cause telomere attrition which can lead to oncogenic incidence in human. Cancer is a disease which is induced by genetic alternations in genes. The genetic mutation within the hTERT is a common type of scenario which is generally found above 90 percent of cancer. In cancer, the length of telomere and the activity of telomerase are very important for cancer cells to proliferate and also for the survival of tumors. Cancer cells regulate through several pathways to increase telomerase activity. There have been several advancements developed to inhibit the telomerase activity in cancer cell but the repercussion of those has demonstrated many adverse effects. Research on AAVs mediated telomerase gene therapy has demonstrated prominent outcomes in animal trials. Thus, it has the potential to bring significance shine in the telomerase cancer therapeutics. Here, in this review article we have analyzed studies related to telomerase gene therapeutics to cure cancer. We also have summarized the telomerase function and mechanism of action to cause cancer. Moreover, other current development in the clinical advances of telomerase inhibition in cancer is described.
Potential Routes and Innovative Technologies for Valorisation of Cassava Peels
Authors: Nyakuma Bemgba B.
Published: October 2021

The large-scale processing of Cassava (Manihot esculenta Crantz.) generates significant quantities of solid wastes annually. Cassava peels (CP) account for 5 wt.% - 30 wt.% of wastes from the processing of cassava tubers. The poor disposal and management of CP pose risks to human health, safety and the environment. Therefore, there is an urgent need to identify and examine low cost, socially acceptable and environmentally friendly strategies to mitigate the immediate and long terms disposal and management challenges. Lack of such measures results in the accumulation of CP wastes, which are currently buried, combusted, or dumped in open fields. Therefore, this paper reviewed the potential routes for the biochemical, thermochemical, and plasma valorisation of CP. The literature reviewed revealed that biochemical technologies such as anaerobic digestion (AD) and fermentation are the most widely utilised approaches currently adopted for CP valorisation. AD produces biogas (methane 50-72 vol. % and carbon dioxide 25-45 vol. %), whereas fermentation yields bioethanol. However, the numerous challenges such as substrate-induced inhibition, associated with the biochemical processes hamper microbial degradation, methane formation, and process efficiency. Furthermore, the processes generate secondary wastes or digestate/sludge, which requires additional processing before disposal. Therefore, innovative thermal, thermochemical, and plasma technologies were proposed to valorise CP into syngas, biofuels, bioenergy, biochemicals, and fertilizers, among others. However, the waste products of fermentation cannot be effectively utilised as bio-fertilizers, whereas bioethanol causes corrosion in engines. Overall, the biochemical, thermal, thermochemical and plasma technologies can effectively valorise CP for effective net energy generation.
Buku Ajar Metodologi Pengembangan Motorik Halus Anak Usia Dini
Authors: Aulina Choirun Nisak
Published: October 2021

Puji syukur kehadirat Allah SWT atas segala anugerah dan rahmat-Nya, sehingga Buku Ajar Metodologi Pengembangan Motorik Halus Anak Usia Dini untuk Tingkat Perguruan Tinggi ini dapat terselesaikan dengan baik.Buku Ajar Metodologi Pengembangan Motorik Halus Anak Usia Dini ini terdiri dari 7 Bab Materi Perkuliahan, yang terdiri dari (1) Hakikat Perkembangan Motorik; (2) Perkembangan Kemampuan Motorik Halus; (3) Tahap Perkembangan Motorik; (4) Gangguan Perkembangan Motorik Halus; (5) Pengembangan Motorik Halus di TK; (6) Program Stimulasi Motorik Halus Anak Usia 0-6 Tahun; (7) Assesmen Perkembangan Motorik Halus Anak. Materi ini merupakan satu kesatuan materi yang dipelajari oleh mahasiswa secara menyeluruh dan tak terpisahkan selama satu semester karena merupakan satu kesatuan yang utuh dalam Capaian Kompetensi di Rencana Pembelajaran Semester .Tujuan diterbitkan buku ini untuk membantu mahasiswa agar dapat menguasai metodologi pengembangan motorik halus anak usia dini secara mudah, dan utuh. Di samping itu pula, buku ini dapat digunakan sebagai acuan bagi dosen yang mengampu mata kuliah Metodologi Pengembangan Motorik Halus Anak Usia Dini. Isi buku ini memuat 5 komponen utama yaitu; pendahuluan, penyajian materi, rangkuman, evaluasi dan daftar pustaka. Buku Ajar Buku Ajar Metodologi Pengembangan Motorik Halus Anak Usia Dini untuk Tingkat Perguruan Tinggi ini diterbitkan oleh UMSIDA Press. Buku Ajar ini merupakan buku terbitan edisi pertama yang tentunya masih butuh disempurnakan.
FOREIGN TRADE, EDUCATION, AND INNOVATIVE PERFORMANCE: A MULTILEVEL ANALYSIS
Authors: Aysan Ahmet Faruk , Castillo-Téllez Luis Carlos , Demirbaş Dilek , Disli Mustafa
Published: October 2021

This study analyses the innovative performance of 5,273 companies across 64 different economic sectors and 32 different regions in Colombia. We assess the effects of education and open economy variables on the innovative performance of firms by analyzing firm, sectoral, and regional level determinants. The study takes the multilevel approach of the innovation process considering the structure and behavior of innovation systems in developing countries. We furthermore focus on technology transfer from foreign trade and the role of education in the process of innovation. We find that education and open economy variables have a significant relationship with innovation performance at the firm and regional levels. We finally conclude that Colombia has a fragmented innovation system with a weak institutional structure, and low interaction between policymakers, industry, universities, research centers.
VOLATILITY SPILLOVER OF INTRADAY EXCHANGE RATES ON SOME SELECTED ASEAN COUNTRIES
Authors: Devpura Neluka , Gunadi Iman , Sasongko Aryo
Published: October 2021

In this paper, we use hourly exchange rate data for selected ASEAN countries (Singapore, Indonesia, Malaysia, Thailand and the Philippines) to test the hypothesis that exchange rate own shocks dominate exchange rate volatility. We find strong evidence that own exchange rate volatility explains between 64% to 86% of their own exchange rate volatility movements. These results do not change when we include the Chinese CNY currency in the analysis. Moreover, we find that exchange rate shocks of ASEAN countries explain 36%, 24% and 23% of exchange rate volatility movements of Indonesia, Thailand, and Singapore, suggesting that for these countries are more synchronized.
Fast Fluoride Ion Conduction in Molecular Cation-Containing Compounds, NH4(Mg1-xLix)F3-x and (NH4)2(Mg1-xLix)F4-x
Authors: Motohashi Kota , Matsukawa Yosuke , Nakamura Takashi , Kimura Yuta , Uchimoto Yoshiharu , Amezawa Koji
Published: October 2021

Aiming development of the fast anion conductors, we proposed a new material design using flexible molecular cation as a host cation, and demonstrated it with fluoride ion conduction in NH4(Mg1-xLix)F3-x and (NH4)2(Mg1-xLix)F4-x. Relatively high fluoride ion conductivities of 4.8×10-5 S cm-1 and 8.4×10-6 S cm-1 were achieved at 323 K in (NH4)2(Mg0.85Li0.15)F3.85 and NH4(Mg0.9Li0.1)F2.9, respectively. Our findings suggest molecular cation-containing compounds can be attractive material groups for fast anion conductors.
The Impact of CK-MB Elevation in Patients With Acute Type A Aortic Dissection With Coronary Artery Involvement
Authors: Minamidate Naoshi , Suzuki Tomoaki
Published: October 2021

Background

Acute coronary artery involvement (ACI) is a lethal complication of acute type A aortic dissection. Although ACI has been reported as one of the prognostic factors of acute type A aortic dissection, it does not always cause coronary ischemia. The extent of myocardial damage varies from case to case. Moreover, since the definition of ACI varies from paper to paper, it is unknown what the difference is between ACI with and without myocardial necrosis. In general, it can be assumed that cases with myocardial infarction have worse results. However, it is unknown how poor ACI is with myocardiac ischemia and how optimistic it is without it. This study compared the surgical results between the two groups of ACI with or without myocardiac ischemia.
Methods

Among 348 patients who underwent an emergency operation for acute type A aortic dissection, there were 28 (8.0%) patients complicated by ACI and underwent additional coronary artery bypass grafting. We divided 26 of those patients into two groups; the MI group ( with CK-MB elevation) and the NMI group (without CK-MB elevation) and compared both groups.
Results

Of the 26, sixteen were in the MI group, and ten were in the NMI group. The average CK-MB in the MI group was 225.5 IU/L, and that in the NMI group was 13.5 IU/L. The mean time from onset to surgery was 248 minutes in the MI group, 250 minutes in the NMI group. There was statistical significance in mortality ( 69% vs. 13%, p=0.03). There was no significance in major complications (ICU days, reintubation, reoperation, pneumonia, sepsis).
Conclusions

Acute coronary artery involvement was associated with 8.0% of patients with ATAAD, and 62% of them had myocardial ischemia with CK-MB elevation. As expected, the MI group had significantly higher mortality than the NMI group. It is crucial for cases with suspected ACI to obtain coronary perfusion as soon as possible to prevent CK-MB from elevationg.
Clinical Characteristics, Risk Factors and Outcomes of MRSA Pneumonia with Secondary MRSA Bloodstream Infection
Authors: Huang Fangfang , Shen Ting , Xin Hai , Xiu Huiqing , Zhang Kai , Huang Tiancha , Chen Juan , Guan Zhihui , Zhou Hongwei , Cai Jiachang , Cai Zhijian , Cui Wei , Zhang Shufang , Zhang Gensheng
Published: October 2021

BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) pneumonia (MP) and MRSA bloodstream infections (MRSA-BSI) are relatively often described, but MP with secondary MRSA-BSI (termed as MP-BSI) is few reported. Herein, we attempted to investigate the clinical features, risk factors and outcomes of MP-BSI in comparison with MP alone.MethodsClinical data from patients with MP was retrospectively collected. The cases were divided into groups of MP alone and MP-BSI. Determination of independent risk factors for MP-BSI relied on binomial logistic regression analysis. In addition, the outcomes were also compared.ResultsA total of 435 patients with MP were recruited, 18.9% (82/435) of whom was MP-BSI. The median age was 62 (interquartile range,51,72) years, and 74.5% were male. Multivariate analysis revealed that high SOFA score, immunosuppression, community-acquired MRSA pneumonia (CA-MP), time from initial to targeted antibiotics, accelerated respiratory rate, elevated γ-GT (all p<0.05) were independent risk factors for MP-BSI, while targeted treatment with linezolid was a protective factor. The median length of hospitalization, 28-day mortality, and in-hospital mortality among total patients were 26 days, 13.6%, and 17.0%, respectively. Patients with MP-BSI had longer length of hospitalization, higher 28-day mortality and in-hospital mortality (all p<0.05).Conclusions﻿Secondary MRSA-BSI among MRSA pneumonia is not uncommon. High SOFA score, immunosuppression, CA-MP, time from initial to targeted antibiotics, accelerated respiratory rate and elevated γ-GT are independent risk factors for MP with secondary MRSA-BSI; importantly, linezolid as targeted antibiotic is a protective factor. In addition, patients with MP have worse clinical outcomes when they are developed with MRSA-BSI.
Comparison of Survival Between Patients Receiving General Ambulatory Palliative Care and Patients Receiving Other Palliative Care - Analysis of Data of a Statutory Health Insurance Data
Authors: Moon Kilson , Rehner Laura , Hoffmann Wolfgang , Berg Neeltje van den
Published: October 2021

Background The care of palliative patients takes place as non-specialized and specialized care, in both ambulatory and stationary settings. However, palliative care is largely provided as non-specialized care in the ambulatory sector (AAPV). This study aimed to investigate whether the survival curves of AAPV patients differed from those of the more intensive palliative care modalities and whether AAPV palliative care was appropriate in terms of timing.Methods The study is based on claims data from a large statutory health insurance. The analysis included 4,177 patients who received palliative care starting in 2015 and who were fully insured one year before and one year after palliative care or until death. The probability of survival was observed for 12 months. Patients were classified into group A, which consisted of patients who received palliative care only with AAPV, and group B including patients who received stationary or specialized ambulatory palliative care. Group A was further divided into two subgroups. Patients who received AAPV on only 1 day were assigned to Subgroup A1, and patients who received AAPV on two or more days were assigned to Subgroup A2. The survival analysis was carried out using Kaplan-Meier curves. The median survival times were compared with the log-rank test.Results The survival curves differed between groups A and B, except in the first quartile of the survival distribution. The median survival was significantly longer in group A (137 days, n=2,763) than in group B (47 days, n=1,424, p<0.0001) and shorter in group A1 (35 days, n=986) than in group A2 (217 days, n=1,767, p<0.0001). The survival rate during the 12-month follow-up was higher in group A (42%) than in group B (11%) and lower in group A1 (38%) than in group A2 (44%).Conclusions The results of the analysis revealed that patients who received the first palliative care shortly before death suspected insufficient care, especially patients who received AAPV for only 1 day and no further palliative care until death or 12-month follow-up. Palliative care should start as early as necessary and be continuous until the end of life.