bluuebunny/crossref_metadata_2025 huggingface dataset:
Weathered remains: Bioarchaeology, identity, and the landscape
Authors: Ellis Meredith A. B.
Published: December 2023

This article explores the making of identity for two sets of human skeletal remains, labeled 1928 Hurricane Victims 1 and 2 Belle Glade. The remains are so poorly preserved that traditional bioarchaeological analysis to explore their perimortem identity is not possible. However, an exploration of their postmortem identity allows us to examine the relationship between landscape, soil, memory, and bodies in bioarchaeology. This article challenges us to consider how bioarchaeology “makes” identity. It does so against the backdrop of one of the worst natural history disasters in United States history, the 1928 Lake Okeechobee Hurricane in Belle Glade, Florida. The loss of some 2,000 to 3,000 individuals in one night, primarily Black migrant farm laborers, is little remembered in national history, but it profoundly shaped the region, and contributes to an ongoing creation of a category of skeletal remains found in the area even today and labeled hurricane victims.
Care and COVID 19: Lessons for liberals and neoliberals
Authors: Lynch Kathleen
Published: December 2023

Within the liberal political traditions, care is regarded as a private matter, a problem of ethics rather than justice. Social justice is framed as an issue of economics (re/distribution), culture (recognition) and/or politics (representation). The pandemic challenged this liberal patriarchal paradigm; it placed the care relational lives of human beings centre stage in terms of social justice, not only in terms of who did or did not do the caring, who was and was not cared for, but who was capable of caring while balancing paid‐work time with care‐work time. The pandemic also challenged dominant ontological assumptions about the human condition, especially assumptions about invulnerability and autonomy that are so pervasive in a neoliberal capitalist era. The vulnerability of the human body came into sharp relief, especially in Western countries where infectious diseases were assumed to be under control. The autonomy myth was shattered too, as unforeseen and uncontrollable social isolation created emotional and relational vulnerabilities. People learned, often in painful ways how the loss of companionship diminished their sense of who they were. Above all, the pandemic demonstrated that the both the personal and professional care infrastructure of societies is foundational to economic, political, cultural and environmental life. It highlighted how affective equality, that is, equality in the doing and receiving of love care and solidarity, is a key dimension of social justice. Consequently, it taught a lesson on why a care/needs‐based concept of justice is as important as a rights‐based theory and why one is incomplete without the other.
Hybrid human‐porcine factor VIII proteins partially escape the inhibitory effects of anti‐factor VIII inhibitor alloantibodies having A2 or C2 domain specificity
Authors: Mizumachi Kuniyoshi , Nakajima Yuto , Shimonishi Naruto , Furukawa Shoko , Ogiwara Kenichi , Takeyama Masahiro , Nogami Keiji
Published: December 2023

Introduction

Porcine factor (pF)VIII has low cross‐reactivity with anti‐human (h)FVIII inhibitor alloantibodies. Clinical trials of pFVIII in congenital haemophilia A patients with inhibitor (PwHA‐I) are in progress. Most polyclonal anti‐hFVIII inhibitors recognize its A2 and/or C2 domain(s), and recombinant human‐porcine hybrid (hp)FVIII proteins may escape neutralization by these inhibitors.

Aim

To evaluate the ability of hpFVIII to limit the anti‐FVIII activity of inhibitor alloantibodies.

Methods

Three hybrid proteins were created by substituting the hFVIII A2, C2 domain or both with the corresponding domains of pFVIII [termed hp(A2), hp(C2) and hp(A2/C2), respectively]. The reactivity of these hybrids was assessed by one‐stage clotting assays (OSA), thrombin generation assays (TGA) and rotational thromboelastometry (ROTEM) by adding them to FVIII‐deficient samples.

Results

OSA demonstrated that the hybrid proteins avoided neutralization by anti‐FVIII A2 or C2 monoclonal antibodies (mAb) and polyclonal inhibitor‐antibodies (polyAb) from PwHA‐I. In TGA, thrombin generation with hp(A2) and hp(A2/C2) was not attenuated in the presence of patient IgG recognizing anti‐A2 domain. In contrast, that with hFVIII and hp(C2) was suppressed by this IgG to levels equivalent to those of FVIII‐deficient plasma. With anti‐A2/C2 polyAb, the activity of hp(A2/C2) was unaffected. ROTEM demonstrated that the addition of hp(A2) or hp(A2/C2) to anti‐A2 polyAb shortened clot times/clot formation times, whilst hFVIII or hp(C2) were ineffective. Similarly with anti‐A2/C2 polyAb, hp(A2/C2) restored coagulation potential to a greater extent than hp(A2) and hp(C2).

Conclusion

Hybrid FVIII proteins containing porcine FVIII A2 and/or C2 domain(s) could support effective therapy in PwHA‐I by avoiding neutralization.
Hot topics in butterfly research: Current knowledge and gaps in understanding of the impacts of temperature on butterflies
Authors: Ashe‐Jepson Esme , Bru Elisabeth , Connell Eleanor , Dixit Mahika K. , Hargrave Jack , Lavitt Tate , Lam Miranda , Prosser Rosa , Roberts Benjamin J. , Thompson Bradley , Bladon Andrew J. , Turner Edgar C.
Published: December 2023

As small poikilotherms, insects are largely dependent on their environment for thermoregulation and so are particularly vulnerable to changing temperatures.

Butterflies are a well‐studied group often used as models to investigate insect responses to temperature. However, little has been done to synthesise and present this large volume of literature in an accessible format, particularly with reference to knowledge gaps and areas rich in information. Using a systematic mapping method, we synthesised the last 40 years of research on the topic of butterfly responses to temperature.

We identified and coded 451 research papers, in which butterfly species were studied 3198 times. We identified taxonomic groups, regions and experimental designs that were well or poorly represented.

We found that there was a relatively good balance of representation across butterfly families in relation to the number of species within each family. The tropics were less frequently studied than temperate regions, and there were more studies reporting outcomes on adults than at any other life stage. Finally, in situ studies were more common than ex situ studies.

Taken together, the higher representation of certain regions, life stages and approaches could lead to an incomplete understanding of the impacts of temperature on butterflies, potentially resulting in ill‐informed decisions.

We make suggestions for how to resolve these discrepancies in representation, including calling for an increased focus on the tropics, the establishment of butterfly monitoring schemes in the global south, a greater focus on the effects of temperature on non‐adult life stages, an increase in experiments investigating fluctuating thermal regimes and the incorporation of more behavioural responses to temperature in future research. Only by addressing these disparities can we gain a complete understanding of how butterflies will respond to climate change.
Optimizing raw material composition to increase sustainability in porcelain tile production: A simulation‐based approach
Authors: Alves Carine Lourenco , Skorych Vasyl , De Noni Agenor , Hotza Dachamir , González S. Y. Gómez , Heinrich Stefan
Published: December 2023

Reducing the environmental impact of porcelain tile production while maintaining cost‐effectiveness is challenging. This work introduced a novel modeling approach for optimizing a standard composition range comprising kaolinite (15–38 wt.%), illite (0–20 wt.%), quartz (20–40 wt.%), and feldspar (20–45 wt.%) to establish a robust composition interval for porcelain stoneware tiles. The proposed study considers several factors, such as composition impact on the manufacturing sequence, production costs, and CO2 emission. A flowsheet simulation database was generated by coupling the Dyssol framework with MATLAB. This study investigated the influence of raw material composition within the process sequence, the total CO2 emissions, and production costs within the contexts of Spain and Brazil, two of the top five global producers. Granules with a higher proportion of talc and illite exhibit reduced moisture content after spray drying, and these combinations have lower green body porosity after compaction. The addition of talc allowed for decreased porosity content after compaction reduced firing temperature, and lowered costs and CO2 emissions despite the higher prices associated with talc. The proposed simulation methodology offers a powerful decision‐making tool for optimizing raw material composition to minimize cost and CO2 emissions in the porcelain tile production. This methodology represents an early stride toward integrating digital twin methodologies within the ceramic tile sector, facilitating improved process regulation, and promoting the adoption of digital technologies.
Gross Worker Flows over the Life Cycle
Authors: CAJNER TOMAZ , GÜNER İLHAN , MUKOYAMA TOSHIHIKO
Published: December 2023

We analyze the gross worker flows over the life cycle by constructing a quantitative general equilibrium model. Using U.S. data, we first document the life‐cycle patterns of flows across different labor market states (employment, unemployment, and not in the labor force), as well as job‐to‐job transitions. We then build a model of the aggregate labor market that incorporates the life cycle of workers, consumption‐saving decisions, and labor market frictions. We estimate the model and use it to examine the effects of policies on aggregate labor market outcomes. In particular, we analyze a taxes‐and‐transfers policy and an unemployment insurance policy.
Forbearance versus Foreclosure in a General Equilibrium Model
Authors: BARBARO BIANCA , TIRELLI PATRIZIO
Published: December 2023

In a business cycle model with endogenous firms' dynamics and debt renegotiation, we show that during financial crises loan forbearance does not harm the economy unless banks imperfectly monitor loans, and loan opacity worsens banks' moral hazard problem. Aggressive interest rate reductions and quantitative easing limit defaults and financial crisis‐induced output contractions without hampering the entry of new firm entries. The decline in the natural interest rate, due to slower productivity growth and persistent liquidity shocks, potentially explains the observed long‐term trend in nonperforming loan shares.
Association between a maternal vegetarian diet during pregnancy and the occurrence of atopic dermatitis in children
Authors: Su Yi‐Chun , Xie Jia‐Shan , Jan Rong‐Hwa , Hsieh Chia‐Jung
Published: December 2023

Background

Atopic dermatitis (AD) is rising globally, with genetics and environmental factors both playing crucial roles. Dietary habits during pregnancy are linked to children's allergic disease risk. However, limited studies have explored the association between maternal vegetarian diets during pregnancy and child AD. Therefore, this study aimed to examine the relationship between maternal vegetarian diets during pregnancy and the occurrence of AD in children.

Methods

In this study, the Taiwan Birth Cohort Study (TBCS) database was used, comprising a representative national birth cohort of infants born in Taiwan in 2005. Of 24,200 mother–child pairs in the database, 20,172 completed face‐to‐face interviews at 6 and 18 months. Employing a 1:10 matching strategy based on maternal age, education level, and child sex, 408 mothers who followed a vegetarian diet during pregnancy were matched with 4080 nonvegetarian mothers. This resulted in a final dataset of 4488 subjects. Logistic regression was used to explore the association between maternal vegetarian diets during pregnancy and the occurrence of AD in children.

Results

Among the TBCS participants, there were 292 (1.8%) mothers who adhered to lacto‐ovo vegetarianism and 116 (0.7%) mothers who adhered to veganism, totaling 408 (2.4%) vegetarians during pregnancy. Compared to children of nonvegetarian mothers, children of mothers who followed a vegetarian diet during pregnancy showed a lower risk of developing AD before 18 months of age (OR = 0.65, 95% CI = 0.45–0.93, p = 0.018).

Conclusion

This study suggests that a vegetarian diet during pregnancy may lower the risk of AD in children. It is essential to carry out long‐term follow‐up to fully understand the impact of a mother's diet on allergic conditions.
Potential of UV‐B radiation in drought stress resilience: A multidimensional approach to plant adaptation and future implications
Authors: Shoaib Noman , Pan Kaiwen , Mughal Nishbah , Raza Ali , Liu Liling , Zhang Juan , Wu Xiaogang , Sun Xiaoming , Zhang Lin , Pan Zhifen
Published: December 2023

The escalating impact of climate change and ultraviolet (UV) radiation is subjecting plants to unique combinations of UV‐B and drought stress. These combined stressors could have additive, synergistic, or antagonistic effects, but the precise nature of these impacts remains uncertain, hampering our ability to predict plant adaptations approach towards stressors. Our analysis of various studies shows that UV‐B or drought conditions detrimentally influence plant growth and health metrics by the enhanced generation of reactive oxygen species causing damage to lipids, proteins, carbohydrates and DNA. Further reducing biomass accumulation, plant height, photosynthetic efficiency, leaf area, and water transpiration, while enhancing stress‐related symptoms. In response to UV‐B radiation and drought stress, plants exhibit a notable up‐regulation of specific acclimation‐associated metabolites, including proline, flavonoids, anthocyanins, unsaturated fatty acids, and antioxidants. These metabolites play a pivotal role in conferring protection against environmental stresses. Their biosynthesis and functional roles are potentially modulated by signalling molecules such as hydrogen peroxide, abscisic acid, jasmonic acid, salicylic acid, and ethylene, all of which have associated genetic markers that further elucidate their involvement in stress response pathways. In comparison to single stress, the combination of UV‐B and drought induces the plant defence responses and growth retardation which are less‐than‐additive. This sub‐additive response, consistent across different study environments, suggests the possibility of a cross‐resistance mechanism. Our outlines imply that the adverse effects of increased drought and UV‐B could potentially be mitigated by cross‐talk between UV‐B and drought regimes utilizing a multidimensional approach. This crucial insight could contribute significantly to refining our understanding of stress tolerance in the face of ongoing global climate change.
From Representation to Sabotage: The New Practices of Russian Antiwar Groups
Authors: Aizman Ania
Published: December 2023

Since February 24, 2022, new oppositional groups—Feminist Antiwar Resistance (FAR), Stop the Wagons, Combat Organization of Anarcho‐Communists (BOAK), the Russian Freedom Legion, and others—have emerged in Russia. Politically, they range from socialist and anarchist to nationalist or fascist, and in their visual media present a range of anonymous protest subjectivities, from the young feminist female artist to the Molotov cocktail‐throwing anarchist to the army defector. Differences notwithstanding, antiwar groups resemble one another in their use of anonymity and sabotage, departing from the culture of the prewar Russian opposition to Putin. The new antiwar groups seek to demonstrate the existence of a broad decentralized movement, but one that continues, rather than disrupts, historical narratives. This article pays special attention to narratives produced by “railway partisans” currently operating in Russia and Belarus, analyzing how they challenge, through tactic as well as rhetoric, their regimes’ uses of World War II history for state‐building myths. I find that antiwar activists claim that sabotage, vandalism, and other forms of material damage represent continuity—rather than break or rupture—with historic forms of grassroots resistance.
Neural Network-Based Region Tracking Control for a Flexible-Joint Robot Manipulator
Authors: Yu Jinwei , Wu Mengyang , Ji Jinchen , Yang Weihua
Published: December 2023

The present paper proposes a neural network-based adaptive region-tracking control strategy for a flexible-joint robot manipulator subjected to region constraints. The developed neural network-based control strategy can globally stabilize the robot manipulator and cope with model uncertainties and the external unknown bounded disturbances. Different from the existing literature, by using the sliding mode technology and the singular perturbation theory, the developed control strategy does not require the high-order derivatives of the link states such as jerk and acceleration since the high-order derivative information is not always available in practical applications. By using Lyapunov stability theory, it is proved that the proposed neural network-based control strategy can guarantee that all the parameter variables in the closed-loop system are bounded, and the flexible-joint robot manipulator with unknown dynamics can reach inside the dynamic region and also maintain the velocity matching with the desired moving region. Since the assumption of linearization of the unknown dynamic parameters is removed, the proposed control strategy does not require the calculation of the complex regression matrix. Therefore, the proposed method has great robustness and the ability of model generalization. Simulations are given to demonstrate the validity of the proposed control strategy.
Multistable States and Snap-Through Instabilities in an Interconnected Dielectric Elastomer Actuators System
Authors: Patra Sanjeet , Mahapatra Shreesh , Godaba Hareesh
Published: December 2023

Snap-through instabilities in single and interconnected dielectric elastomer actuators have demonstrated their potential in enabling many functionalities such as large deformation, high-speed actuation, and enhanced flowrates in fluid pumps. However, the nonlinear nature of dielectric elastomers and the complex interplay of mechanics in interconnected inflated actuators, make the modeling of such systems challenging. In this paper, we present a methodology to analytically model the instabilities in a system of three interconnected homogeneous spherical dielectric elastomer actuators through graphical and numerical approaches. The simulation results reveal the presence of a locus of initial stable states that the interconnected actuators can achieve at zero voltage. In specific loading conditions, the system exhibits multiple stable states which can be cyclically transitioned between by selectively applying voltage to specific actuators. In other conditions, the system may undergo two successive instabilities when the voltage applied to a single actuator in the system is increased monotonically. These results retrieve existing experimental results theoretically for the first time and identify a new behavior of cascading instabilities in inflated dielectric elastomer actuators. We hope this work will pave the way for programmable design of multistable systems to unravel new capabilities in dielectric elastomer actuators and soft robotics.
Pressure Sensitive Paint and Large Eddy Simulation Investigation on the Impact of Trench Depth on Flat Plate Film Cooling Through Shaped Holes
Authors: Abdeh H. , Barigozzi G. , Zamiri A. , Chung J. T.
Published: December 2023

To increase film cooling effectiveness levels downstream of film cooling holes, trenches manufactured in the thermal barrier coating can be adopted. The performance of this solution depends on the trench geometrical characteristics, namely its depth and width. A large eddy simulation (LES)-based numerical study has been performed at Korea University to investigate the effects of trench configuration on thermal protection, resulting in a 22% increase in cooling performance compared to the reference case without a trench. The present paper reports the results of an experimental investigation carried out at Bergamo University on a Plexiglass flat plate model with a set of three fan-shaped holes incorporated into an existing wind tunnel, replicating the numerical setup. Pressure-sensitive paint (PSP) technique was used to measure the adiabatic film cooling effectiveness. Besides the standard shaped hole case, the best and worst trench configurations coming from a DoE approach have been examined at various coolant to mainstream blowing ratios M in the range between 0.5 and 3. Cases at M = 1.5 were used to cross-check the prediction capability of the LES numerical simulation for the selected trenched cases. PSP and LES results are in good agreement, also with the literature data. The high depth/low width trench was shown to give an improved performance for M larger than 1.
Drive Layout Configuration Strategy and Scale Optimization Design of Multi-Drive Mode Parallel Mechanism
Authors: Han Ming , Xiong Bin , Liu Jinyue , Yang Dong , Li Tiejun
Published: December 2023

Aiming at the inherent defects of single-drive mode parallel mechanisms, such as small good workspace and many singular configurations, a new multi-drive mode parallel mechanism is proposed from the perspective of driving innovation. Taking the planar 6R parallel mechanism as an example, the driving layout configuration strategy and scale optimization design are studied. First, the potential driving layout of the mechanism is analyzed, and the inverse kinematics model of the mechanism is established. Then, based on the motion/force transmission index, the singular space and good transmission workspace of the mechanism are identified, and the mechanism-driven layout configuration strategy is formulated to complete the performance comparison analysis. Finally, based on the performance map method, the scale optimization design of the mechanism is carried out, the prototype is developed and manufactured, and the experimental verification is carried out. The research results show that the multi-drive mode parallel mechanism can improve its kinematic performance without changing the topological structure and scale parameters of the mechanism.
Anatomical adventures in the fish auditory medulla
Authors: McCormick Catherine A.
Published: December 2023

This paper provides an overview of my work on the central auditory system of fish. It focuses on my comparative analyses of a nucleus that receives input from the inner ear, the descending nucleus, and more specifically on that part of the descending nucleus supplied by the otolith end organs, the dorsal descending nucleus. I begin by summarizing my initial work on the bowfin, Amia calva, and go on to explain the importance of taking a comparative approach to understanding ancestral and specialized anatomical and putative functional characteristics of the dorsal descending nucleus in modern bony fishes, the teleosts.
Safety and feasibility of intra-arterial delivery of teniposide to high grade gliomas after blood–brain barrier disruption: a case series
Authors: Ruan Jian , Shi You , Luo Pengren , Li Lin , Huang Jiashang , Chen Jie , Yang Haifeng
Published: December 2023

Background

This case series describes the safety and efficacy of superselective intra-arterial (IA) cerebral infusion of teniposide for the treatment of patients with glioma, to provide new ideas and methods for the treatment of high grade gliomas.

Methods

12 patients with glioma who were previously treated with standard therapy were treated with superselective IA cerebral infusion of teniposide. Patients received at least two cycles of treatment (one cycle: 150 mg/time, used for 1 day, repeated at 28 day intervals) after blood–brain barrier disruption. Patients received individualized treatment on the tumor location. The ophthalmic artery was bypassed during the super-selective arterial infusion.

Results

No significant differences in biochemical indexes and Karnofsky performance status (KPS) score were observed before and after treatment, and no evident adverse events occurred (P>0.05). In a recent response evaluation (August 2023), two (8%) patients presented with a complete response (16.7%), four had a partial response (33.3%), four had stable disease (33.3%), and two showed progressive disease (16.7%). The overall response rate and disease control rate were 50.0% and 83.3%, respectively. In addition, we described the detailed course of treatment in two patients. Case No 1 (recurrent tumor) and case No 2 (primary tumor) received six and three cycles of teniposide infusion, respectively. After treatment, the tumors of the patients were significantly reduced without evident adverse effects.

Conclusion

This small series suggests that superselective IA cerebral infusion of teniposide may be a safe and effective therapy in the multimodal treatment of malignant glioma and warrants further study in larger prospective investigations.
Ethnic variation in asthma phenotypic presentation and outcomes: a cross-sectional analysis of the UK Biobank
Authors: Busby John , McDowell P Jane , Pfeffer Paul E , Mansur Adel Hasan , Heaney Liam G
Published: December 2023

Ethnic disparities exist within asthma; however, country of birth is rarely investigated. We described demographic and clinical characteristics by ethnicity and country of birth within the UK Biobank. Lung function and asthma hospitalisations were similar for white, black and North-East Asian participants, however, South-East (SE) Asians more commonly had an FEV1below the lower limits of normal (LLN; 53.8% vs 32.3%, p<0.001), blood eosinophilia (38.6% vs 23.8%, p<0.001) and asthma hospitalisation (12.5% vs 8.3%, p<0.001) than white participants. First-generation SE Asian immigrants had poorer lung function (57.7% vs 27.7% FEV1below LLN, p<0.001) than UK/Ireland born participants. These data demonstrate inter-ethnic and intra-ethnic disparities.
Lipid vesicle pools studied by passive X-ray microrheology
Authors: Czajka Titus , Neuhaus Charlotte , Alfken Jette , Stammer Moritz , Chushkin Yuriy , Pontoni Diego , Hoffmann Christian , Milovanovic Dragomir , Salditt Tim
Published: December 2023

Vesicle pools can form by attractive interaction in a solution, mediated by proteins or divalent ions such as calcium. The pools, which are alternatively also denoted as vesicle clusters, form by liquid-liquid phase separation (LLPS) from an initially homogeneous solution. Due to the short range liquid-like order of vesicles in the pool or cluster, the vesicle-rich phase can also be regarded as a condensate, and one would like to better understand not only the structure of these systems, but also their dynamics. The diffusion of vesicles, in particular, is expected to change when vesicles are arrested in a pool. Here we investigate whether passive microrheology based on X-ray photon correlation spectroscopy (XPCS) is a suitable tool to study model systems of artificial lipid vesicles exhibiting LLPS, and more generally also other heterogeneous biomolecular fluids. We show that by adding highly scattering tracer particles to the solution, valuable information on the single vesicle as well as collective dynamics can be inferred. While the correlation functions reveal freely diffusing tracer particles in solutions at low CaCl$$_{2}$$2concentrations, the relaxation rate$$\Gamma (q)$$Γ(q)shows a nonlinear dependence on$$q^2$$q2at a higher concentration of around 8 mM CaCl$$_{2}$$2, characterised by two linear regimes with a broad cross-over. We explain this finding based on arrested diffusion in percolating vesicle clusters.

Graphic Abstract
The Coding Logic of Interoception
Authors: Wang Ruiqi L. , Chang Rui B.
Published: December 2023

Interoception, the ability to precisely and timely sense internal body signals, is critical for life. The interoceptive system monitors a large variety of mechanical, chemical, hormonal, and pathological cues using specialized organ cells, organ innervating neurons, and brain sensory neurons. It is important for maintaining body homeostasis, providing motivational drives, and regulating autonomic, cognitive, and behavioral functions. However, compared to external sensory systems, our knowledge about how diverse body signals are coded at a system level is quite limited. In this review, we focus on the unique features of interoceptive signals and the organization of the interoceptive system, with the goal of better understanding the coding logic of interoception.
Deconvoluting Slurry Rheology from Binder Performance in Si-Based Anodes
Authors: Jiang Hairui , Wei Congxiao , Yasmin S. , Obrovac M. N.
Published: December 2023

A systematic investigation was undertaken on the effect of sodium poly(acrylic acid) (NaPAA) binder molecular weight on silicon monoxide cycling performance. It was found that cycling performance was poor for low molecular weight binder, however this was primarily related to poor slurry rheology. We found that if propylene glycol is used instead of water as a slurry solvent, it can take over the role of viscosity modifier from the binder. When propylene glycol is used as a solvent for slurries with low MW NaPAA binders (e.g. 1.5 k NaPAA), the cycling outperformance of the resulting SiO electrodes outperforms conventionally made SiO electrodes with high molecular weight binder (e.g. 250 k NaPAA). These results show that binder molecular weight only affects the cycling performance of Si-alloy based electrodes because of its role as a slurry viscosity modifier. If propylene glycol is used to increase slurry viscosity, then the molecular weight has little effect.
Prediction of Condensation in the Heat Exchangers of Engine Intake Systems according to External Environmental and Operating Conditions
Authors: Ju Kangmin , Chung Chungsoo , Lee Jaegun , Park Jungsoo
Published: December 2023

Low-pressure exhaust gas recirculation (LP-EGR) systems are applied to diesel engines because they reduce nitrogen oxide emission by lowering the internal temperature of the cylinder by mixing the oxides with intake air. However, low-temperature ambient conditions include a large amount of vapor in the mixed gas flowing into the intercooler; when heat is exchanged, the water vapor condenses and is adsorbed on the surface of the intercooler fin to form a liquid film. Condensation occurs as the thermal resistance between the vapor and solid surface increases with the thickness of the liquid film and causing a corrosion due to condensation of the surface. In this study, the amount of condensation was predicted through calculations based on thermodynamic studies. Factors that can cause condensation inside the intercooler (fuel, air, and LP-EGR) were selected as variables. A mathematical formula was established to predict the convergence form of condensation or the amount of condensation over time at various temperature and relative humidity conditions. The formula predicted the condensation amount in the intercooler of the diesel engine, compared it to the actual amount of condensation in the test evaluation with an error of less than 4%. Additionally, because the formula can predict the amount of condensation by changing the heat exchange area of the intercooler, the application range of the formula was expanded to predict the condensation in the intercoolers of gasoline vehicles with different heat exchange areas and fuel types. The condensation error was within 2%, indicating a high consistency. Validation of the formula predicts a reliable amount of condensation under various operating and ambient temperature conditions, which means that both the time and cost of the test evaluation require the determination of the cause before solving the actual condensation problem.
Applications of Quantum Probability Amplitude in Decision Support Systems
Authors: Payandeh Shahram
Published: December 2023

Establishing various frameworks for managing uncertainties in decision-making systems have been posing many fundamental challenges to the system design engineers. Quantum paradigm has been introduced to the area of decision and control communities as a possible supporting platform in such uncertainty management. This paper presents an overview of how a quantum framework and, in particular, probability amplitude has been proposed and utilized in the literature to complement two classical probabilistic decision-making approaches. The first such framework is based in the Bayesian network, and the second is based on an element of Dempster–Shafer (DS) theory using the definition of mass function. The paper first presents a summary of these classical approaches, followed by a review of their preliminary enhancements using the quantum model framework. Particular attention was given on how the notion of probability amplitude is utilized in such extensions to the quantum-like framework. Numerical walk-through examples are combined with the presentation of each method in order to better demonstrate the extensions of the proposed frameworks. The main objective is to better define and develop a common platform in order to further explore and experiment with this alternative framework as a part of a decision support system.
Supplementary Table 2 from Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy
Authors: Nowicki Theodore S. , Peters Cole W. , Quiros Crystal , Kidd Conner K. , Kawakami Moe , Klomhaus Alexandra M. , Baselga-Carretero Ignacio , Kaplan-Lefko Paula , Macabali Mignonette H. , Perez Garcilazo Ivan , Berent-Maoz Beata , Comin-Anduix Begoña , Ribas Antoni
Published: December 2023

Supplemental Table 2. Significance measures for correlation matrix between intracellular cytokine FSIs and phosphoprotein FSIs with the CD8 compartment, stimulated conditions. p values for each Pearson’s correlation shown in Supplemental Figure 10B are shown, with statistically significant values highlighted in red.
Supplemental Figure 8 from Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy
Authors: Nowicki Theodore S. , Peters Cole W. , Quiros Crystal , Kidd Conner K. , Kawakami Moe , Klomhaus Alexandra M. , Baselga-Carretero Ignacio , Kaplan-Lefko Paula , Macabali Mignonette H. , Perez Garcilazo Ivan , Berent-Maoz Beata , Comin-Anduix Begoña , Ribas Antoni
Published: December 2023

Aggregate data of single-cell intracellular cytokine functional strength indices (FSI). Groups are divided by T cell subtype, clinical response, and tonic vs stimulated culture conditions. Error bars represent +/- standard error of the mean (SEM).
Supplemental Figure 1 from Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy
Authors: Nowicki Theodore S. , Peters Cole W. , Quiros Crystal , Kidd Conner K. , Kawakami Moe , Klomhaus Alexandra M. , Baselga-Carretero Ignacio , Kaplan-Lefko Paula , Macabali Mignonette H. , Perez Garcilazo Ivan , Berent-Maoz Beata , Comin-Anduix Begoña , Ribas Antoni
Published: December 2023

Overall TNFα cytokine polyfunctionality is associated with superior in vivo antitumor activity of transgenic TCR T cell therapy. Overall TNFα polyfunctional strength index (PSI), i.e. the percentage of polyfunctional single-cells secreting TNF-alpha multiplied by the degree of cytokine secretion intensity, averaged between CD4 and CD8 compartments, was significantly correlated with superior degree of anti-tumor response, as measured by peak percent change in tumor burden per RECIST1.1 criteria.
Figure S7 from Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance
Authors: Echavidre William , Durivault Jérôme , Gotorbe Célia , Blanchard Thays , Pagnuzzi Marina , Vial Valérie , Raes Florian , Broisat Alexis , Villeneuve Rémy , Amblard Régis , Garnier Nicolas , Ortholan Cécile , Faraggi Marc , Serrano Benjamin , Picco Vincent , Montemagno Christopher
Published: December 2023

Cilengitide delays tumor growth in HD-MB03-β3+ orthotopic xenografts. A) Representative images of the BLI signal intensity 30 days after HD-MB03-β3+ tumor implantation, corresponding to the time of first death. Three mice are shown per condition. (B) Tumor growth of HD-MB03-β3+ assessed by luciferase activity. Photon flux was quantified and analyzed using the IVIS imaging system. (C) Survival curves of mice orthotopically implanted with HD-MB03-β3+ cells in the cerebellum and treated with cilengitide. Day 0 corresponds to tumor implantation, and the black arrow indicates the start of treatment. Mice were treated with 300 μg cilengitide three times a week. The median survival (from the start of treatment) is shown at the bottom of the graphs. The p-value is indicated in the graph (Log-rank test). Key: ** p < 0.01 vs. control
Figure S4 from Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance
Authors: Echavidre William , Durivault Jérôme , Gotorbe Célia , Blanchard Thays , Pagnuzzi Marina , Vial Valérie , Raes Florian , Broisat Alexis , Villeneuve Rémy , Amblard Régis , Garnier Nicolas , Ortholan Cécile , Faraggi Marc , Serrano Benjamin , Picco Vincent , Montemagno Christopher
Published: December 2023

Pharmacological disruption of integrin-αvβ3 decreased cell adhesion of integrin-αvβ3 positive MB cell lines. (A) The IC50s for cilengitide determined by MTT and adhesion assays. In the MTT assay, IC50s (μM) were determined after 48 h of exposure to cilengitide. In adhesion assays, 96-well plates were coated with fibronectin (1 μg/well), and cells were allowed to adhere in the presence of cilengitide for 2 h. The IC50s were determined after staining the cells with Crystal Violet (1%), resuspending them in DMSO, and absorbance measurement at 590 nm. (B) 96-well plates were coated with fibronectin (1μg/well), and cells were allowed to adhere in the presence of LM609 at the indicated concentrations for 2 h. Cells were stained the cells with Crystal Violet (1%), resuspending them in DMSO, and absorbance measurement at 590 nm. Key: *, p < 0.05; **, p < 0.01, *** p<0.001 vs control conditions.
Figure S2 from Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance
Authors: Echavidre William , Durivault Jérôme , Gotorbe Célia , Blanchard Thays , Pagnuzzi Marina , Vial Valérie , Raes Florian , Broisat Alexis , Villeneuve Rémy , Amblard Régis , Garnier Nicolas , Ortholan Cécile , Faraggi Marc , Serrano Benjamin , Picco Vincent , Montemagno Christopher
Published: December 2023

ECM-mediated cell adhesion assay using crystal violet staining. DAOY-derived (A-B) and HD-MB03-derived (C) cells were allowed to attach to different ECM proteins coated on 48-wells plates for 30 min. Adherent cells were stained with crystal violet, solubilized with DMSO and quantified at OD560 nm. ** p<0.01 vs DAOY_Ctl or HD-MB03_LacZ; # p<0.05, ## p<0.01 vs DAOY_ β3-overexpressing cells.
FIGURE 4 from Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance
Authors: Echavidre William , Durivault Jérôme , Gotorbe Célia , Blanchard Thays , Pagnuzzi Marina , Vial Valérie , Raes Florian , Broisat Alexis , Villeneuve Rémy , Amblard Régis , Garnier Nicolas , Ortholan Cécile , Faraggi Marc , Serrano Benjamin , Picco Vincent , Montemagno Christopher
Published: December 2023

Antitumor effects of cilengitide are restricted to integrin-αvβ3–positive tumors. A, Representative images of the BLI signal intensity 49 days (DAOY_control, left), 89 days (DAOY-KO#22, middle), and 36 days (HD-MB03_WT, right) after implantation, corresponding to the time of first death. Three mice are shown per condition. B, Tumor growth of DAOY_control (left), DAOY-KO#22 (middle), and HD-MB03_WT (right) as assessed by luciferase activity. Photon flux was quantified and analyzed using the IVIS imaging system. C, Survival curves of mice orthotopically implanted with DAOY_control (left), DAOY KO_#22 (middle), and HD-MB03 (right) cells in the cerebellum and treated with cilengitide. Day 0 corresponds to tumor implantation, and the black arrow indicates the start of treatment. Mice were treated with 300 µg cilengitide three times a week. The median survival (from the start of treatment) is shown at the bottom of the graphs. The P value is indicated in the graph (log-rank test). D, Ki67 labeling of DAOY_control (left), DAOY-KO_#22 (center), and HD-MB03_WT (right) tumor sections. Representative images of Ki67 immunolabeling (green) and Hoechst33342 nuclear DNA counterstaining (blue) are shown at the top of the graphs. E, Vasculature labeling of DAOY_control (left), DAOY-KO_#22 (middle), and HD-MB03_WT (right) tumor sections. Vessels were identified by CD31 and αSMA immunofluorescent staining (green and magenta, respectively). The number of vessels (CD31+ and αSMA+) was determined, and results are expressed as the percentage of control conditions. Key: *, P < 0.05; **, P < 0.01 versus control.
FIGURE 2 from Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance
Authors: Echavidre William , Durivault Jérôme , Gotorbe Célia , Blanchard Thays , Pagnuzzi Marina , Vial Valérie , Raes Florian , Broisat Alexis , Villeneuve Rémy , Amblard Régis , Garnier Nicolas , Ortholan Cécile , Faraggi Marc , Serrano Benjamin , Picco Vincent , Montemagno Christopher
Published: December 2023

Integrin-αvβ3 promotes medulloblastoma intracranial tumor growth rate and increases survival. Representative images of BLI signal intensity 56 days (DAOY_control vs. KO_#22 and KO_#36; A) and 23 days (HD-MB03-LacZ vs. β3+; B) implantation. Three mice are shown per condition. Tumor growth of DAOY_control compared with KO_#22 and KO_#36 (C) and HD-MB03-LacZ compared with β3+ (D) measured by luciferase activity. Photon flux was quantified and analyzed using the IVIS imaging system. Survival curves of mice orthotopically implanted with DAOY_control vesrus KO_#22 and KO_#36 (E) and HD-MB03-LacZ versus β3+ (F) in the cerebellum. Day 0 corresponds to the day of tumor implantation. The median of survival is shown at the bottom of the graphs. The P value is indicated in the graph (log-rank test). Ki67 labeling of DAOY_control versus KO_#22 and KO_#36 (G) and HD-MB03-LacZ versus β3+ (H). Representative images of Ki67 immunostaining (green) and Hoechst33342 nuclear DNA counterstaining (blue) are shown at the top of the graphs. Key: *, P < 0.05; **, P < 0.01 versus control.
Ultrasonography findings in knee osteoarthritis: a prospective observational cross-sectional study of 100 Patients
Authors: Nakada Letícia Naomi , Santos Felipe Ricardo Aquino dos , Abicalaf Claudia Andreia Rabay Pimentel , Imamura Marta , Battistella Linamara Rizzo
Published: December 2023

Introduction: Worldwide, knee osteoarthritis (KOA) accounts for 2.2% of total years lived with disability. There is low correlation between joint tissue damage and pain intensity. Periarticular structures may be involved and cannot be identified in X-rays. Objectives: To describe the main ultrasonography (USG) changes in symptomatic patients with primary KOA; to correlate number of USG findings with KOA severity assessed by Kellgren and Lawrence (K&L) radiological scores, with pain intensity measured by a visual analogue scale (VAS) and with functioning scores assessed with Timed up and go test (TUG) and Western Ontario and McMaster Universities (WOMAC) questionnaire. Methods: 100 patients with primary symptomatic KOA were assessed with X-ray and USG. Quantitative and qualitative analyses were evaluated in a systematic manner. Results: The most frequent findings were joint effusion, pes anserinus bursitis, quadriceps tendon enthesopathy, popliteal cyst, iliotibial band tendinitis and patellar tendinitis. Pearson’s correlation analysis demonstrated a significant moderate positive association between VAS scores and number of USG findings (r=0.36; p<0.0001). The number of USG findings was different between K&L grades I and III (p=0.041), I and IV (p<0.001), and II and IV (p=0.001, ANOVA with Bonferroni correction). There was significant association between number of USG findings and TUG (r=0.18; p=0.014) and WOMAC scores for pain (r=0.16; p<0.029) and physical function domains (r=0.16; p<0.028). Conclusion: The most frequent USG finding was joint effusion. Periarticular structures should be explored as potential sources of pain and disability.
Comparação da percepção da família e do fisioterapeuta utilizando o sistema GMFCS e o Questionário de Relato Familiar
Authors: Silva Francine Souza da , Moura Elcinete Wentz de , Narumia Lisa Carla , Ozu Márcia Harumi Uema
Published: December 2023

A Paralisia Cerebral (PC) é uma patologia amplamente conhecida e estudada entre os profissionais de saúde. No meio acadêmico, possui algumas classificações importantes que auxiliam a comunicação entre a equipe multiprofissional. O Sistema de Classificação da Função Motora Grossa (Gross Motor Function Classification System - GMFCS) classifica a função motora grossa do indivíduo segundo a habilidade do movimento autoiniciado, sendo dividido em cinco níveis. O domínio sobre a classificação e nível motor da criança devem ser de responsabilidade da equipe multiprofissional bem como o conhecimento por parte dos pais e ou responsáveis. Esse saber, muitas vezes pode estar limitado, e com isso a relação entre os profissionais de saúde, família e paciente pode entrar em conflito, gerando dúvidas. Objetivo: Este estudo tem por finalidade quantificar a concordância entre o conhecimento dos pais e/ou responsáveis sobre a classificação da função motora grossa quando comparados à classificação dada pelos fisioterapeutas e médicos, assim como, quantificar o quanto destes pais e/ou responsáveis já tinham um conhecimento prévio da classificação. Método: Trata-se de um estudo prospectivo observacional, com 96 pacientes, aos quais foram analisados em prontuário eletrônico. Sendo aplicado, então, o Questionário de Relato Familiar (GMFCS Family Report Questionnaire). Resultados: Em todas as variáveis dependentes avaliadas demonstrou-se uma taxa de concordância acima dos 60%; o valor de Kappa apresentado foi de k= >0,7, havendo, portanto, uma confiabilidade entre grupos de moderada a forte. Conclusão: Em geral, os profissionais de saúde se apresentam mais suscetíveis a classificarem os pacientes em níveis funcionais melhores do que quando comparados aos pais/responsáveis.
O modelo biopsicosocial na reabilitação por gameterapia na paralisia cerebral: revisão sistemática
Authors: Cabrera Naira Rodrigues de Oliveira , Silva Joyce Karla Machado da , Pellizzari Camila Costa de Araujo , Valenciano Paola Janeiro
Published: December 2023

Objetivo: Investigar os efeitos das intervenções com uso de Realidade Virtual (RV) para crianças com Paralisia Cerebral (PC) baseando-se na estrutura da Classificação Internacional de Funcionalidade, Incapacidade de Saúde (CIF). Método: Trata-se de revisão sistemática de ensaios clínicos randomizados, realizada em julho de 2022. Foram investigadas intervenções relacionadas a fisioterapia associada aos jogos de RV para crianças com PC, idade de 6 a 12 anos nas bases de dados: PubMed, Cochrane, MedLine e PEDro. A qualidade metodológica foi avaliada pela Escala PEDro. Foram incluídos 9 estudos envolvendo total de 310 participantes, destes, 5 estavam inseridos em estrutura e funções do corpo, 9 artigos em atividade e nenhum estudo investigaram o componente participação ou fatores contextuais, sendo que alguns foram incluídos em mais do que um componente da CIF. Resultados: A função manual e o equilíbrio corporal foram os desfechos mais avaliados. Como limitação, destaca-se o pequeno número de estudos e a falta de dados sobre os componentes de participação e fatores contextuais. O ponto forte do estudo foi associar a CIF a uma categoria de reabilitação fisioterapêutica para esta população. Conclusão: Pesquisas experimentais recentes relacionadas ao uso da RV na fisioterapia de crianças com PC estão em sua maioria direcionadas ao componente de atividade da CIF. Mais estudos são necessários a fim de investigar se o aprendizado no ambiente terapêutico é transferido no contexto de vida desses indivíduos e se há impacto na participação e funcionalidade. Número de registro na Prospero: CRD42021260011.