bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of repeat revascularization within 5 years on 10-year mortality after percutaneous or surgical revascularization
Authors: Wang Rutao , Lunardi Mattia , Hara Hironori , Gao Chao , Ono Masafumi , Davierwala Piroze M. , Holmes David R. , Mohr Friedrich W. , Curzen Nick , Burzotta Francesco , van Geuns Robert-Jan , Kappetein Arie Pieter , Head Stuart J. , Thuijs Daniel J. F. M. , Tao Ling , Garg Scot , Onuma Yoshinobu , Wijns William , Serruys Patrick W.
Published: May 2023

Background

The SYNTAX trial demonstrated negative impact of repeat revascularization (RR) on 5-year outcomes following PCI/CABG in patients with three-vessel(3VD) and/or left main coronary artery disease(LMCAD). We aimed to investigate the impact of RR within 5 years, on 10-year mortality in patients with 3VD and/or LMCAD after PCI/CABG.

Methods

The SYNTAXES study evaluated the vital status out to 10 years of patients with 3VD and/or LMCAD. Patients were stratified by RR within 5 years and randomized treatment. The association between RR within 5 years and 10-year mortality was assessed.

Results

A total of 330 out of 1800 patients (18.3%) underwent RR within 5 years. RR occurred more frequently after initial PCI than after initial CABG (25.9% vs. 13.7%, p < 0.001). Overall, 10-year mortality was comparable between patients undergoing RR and those not (28.2% vs. 26.1%, adjusted HR: 1.17, 95%CI 0.93–1.48, p = 0.187). In the PCI arm, RR was associated with a trend toward higher 10-year mortality (adjusted HR: 1.29, 95%CI 0.97–1.72, p = 0.075), while in the CABG arm, the trend was opposite (adjusted HR: 0.74, 95%CI 0.46–1.20, p = 0.219). Among patients requiring RR, those who underwent PCI as initial revascularization had a higher risk of 10-year mortality compared to initial CABG (33.5% vs. 17.6%, adjusted HR: 2.09, 95%CI 1.21–3.61, p = 0.008).

Conclusion

In the SYNTAXES study, RR within 5 years had no impact on 10-year all-cause death in the population overall. Among patients requiring any repeat procedures, 10-year mortality was higher after initial treatment with PCI than after CABG. These exploratory findings should be investigated with larger populations in future studies.

Trial registration

URL: https://www.clinicaltrials.gov; SYNTAXES Unique identifier: NCT03417050. URL: https://www.clinicaltrials.gov; SYNTAX Unique identifier: NCT00114972.

Graphical abstract
Cough Sensitivity to Several External Triggers is Associated with Multiple Non-respiratory Symptoms
Authors: Koskela Heikki O. , Kaulamo Johanna T. , Lätti Anne M.
Published: May 2023

Purpose

Enhanced responsiveness to external triggers is thought to reflect hypersensitivity of the cough reflex. It may involve an enhanced sensitivity of the afferent nerves in the airways and/or an abnormal processing of the afferent information by the central nervous system (CNS). The CNS processing of cough has been shown to involve the same regions as those in symptom amplification, a phenomenon that often manifests as multiple symptoms. The main purpose of the present study was to define whether the presence of several cough triggers is associated with multiple symptoms.

Methods

2131 subjects with current cough responding to two email surveys filled in a comprehensive questionnaire about social background, lifestyle, general health, doctors’ diagnoses and visits, symptoms, and medication. Multiple symptoms was defined as three or more non-respiratory, non-mental symptoms.

Results

A carefully controlled multiple regression analysis revealed that the number of cough triggers was the only cough characteristic associating with multiple non-respiratory, non-mental symptoms [aOR 1.15 (1.12–1.19) per one trigger,p < 0.001]. Among the 268 subjects with current cough both in the first survey and in the follow-up survey 12 months later, the repeatability of the trigger sum was good with an intraclass correlation coefficient of 0.80 (0.75–0.84).

Conclusion

The association between the number of the cough triggers and multiple symptoms suggests that the CNS component of cough hypersensitivity may be a manifestation of non-specific alteration in the CNS interpretation of various body sensations. The number of cough triggers is a repeatable measure of cough sensitivity.
Lymph node evaluation for endometrial hyperplasia: a nationwide analysis of minimally invasive hysterectomy in the ambulatory setting
Authors: Matsuo Koji , Ciesielski Katharine M. , Mandelbaum Rachel S. , Lee Matthew W. , Jooya Neda D. , Roman Lynda D. , Wright Jason D.
Published: May 2023

Background

Given the possibility of occult endometrial cancer where nodal status confers important prognostic and therapeutic data, role of lymph node evaluation at hysterectomy for endometrial hyperplasia is currently under active investigation. The objective of the current study was to examine the characteristics related to lymph node evaluation at the time of minimally invasive hysterectomy when performed for endometrial hyperplasia in an ambulatory surgery setting.

Methods

The Healthcare Cost and Utilization Project's Nationwide Ambulatory Surgery Sample was retrospectively queried to examine 49,698 patients with endometrial hyperplasia who underwent minimally invasive hysterectomy from 1/2016 to 12/2019. A multivariable binary logistic regression model was fitted to assess the characteristics related to lymph node evaluation at hysterectomy and a classification tree model with recursive partitioning analysis was constructed to examine the utilization pattern of lymph node evaluation.

Results

Lymph node evaluation was performed in 2847 (5.7%) patients. In a multivariable analysis, (i) patient factors with older age, obesity, high census-level household income, and large fringe metropolitan, (ii) surgical factors with total laparoscopic hysterectomy and recent year surgery, (iii) hospital parameters with large bed capacity, urban setting, and Western U.S. region, and (iv) histology factor with presence of atypia were independently associated with increased utilization of lymph node evaluation at hysterectomy (all, P < 0.05). Among those independent factors, presence of atypia exhibited the largest association for lymph node evaluation (adjusted odds ratio 3.75, 95% confidence interval 3.39–4.16). There were 20 unique patterns of lymph node evaluation based on histology, hysterectomy type, patient age, year of surgery, and hospital bed capacity, ranging from 0 to 20.3% (absolute rate difference, 20.3%).

Conclusion

Lymph node evaluation at the time of minimally invasive hysterectomy for endometrial hyperplasia in the ambulatory surgery setting appears to be evolving with large variability based on histology type, hysterectomy modality, patient factors, and hospital parameters, warranting a consideration of developing clinical practice guidelines.
An improved bald eagle search optimization algorithm for optimal home energy management systems
Authors: Youssef Heba , Kamel Salah , Hassan Mohamed H. , Nasrat Loai , Jurado Francisco
Published: May 2023

In this study, an improved bald eagle search optimization algorithm (IBES) is utilized to develop home energy management systems for smart homes. This research is crucial for energy field researchers who are interested in optimizing energy consumption. The primary objective is to optimally manage load demand, reduce the average peak ratio, lower electricity bills, and enhance user comfort. To accomplish this goal, the load conversion strategy is used to coordinate household appliances and manage the home power system effectively. This approach aims to minimize peak–average ratios and electricity costs while ensuring consumer convenience. To minimize electricity bills, the study schedules the consumer’s daily activities based on actual time and next day’s energy demand. Furthermore, a fitness criterion is used to balance the load between off-peak and on-peak hours. The scheduler is designed to achieve an optimal device on/off state that minimizes device waiting time by coordinating household appliances in real time. To address the background problem of real-time rescheduling, dynamic programming is employed. The study evaluates the modified algorithm’s performance using three pricing strategies: critical peak pricing, real-time pricing, and time of use. The modified IBES technique is utilized to achieve the specified objectives of minimizing the electricity bill, reducing the peak–average ratio, and enhancing user convenience.
Are current machine learning applications comparable to radiologist classification of degenerate and herniated discs and Modic change? A systematic review and meta-analysis
Authors: Compte Roger , Granville Smith Isabelle , Isaac Amanda , Danckert Nathan , McSweeney Terence , Liantis Panagiotis , Williams Frances M. K.
Published: May 2023

Introduction

Low back pain is the leading contributor to disability burden globally. It is commonly due to degeneration of the lumbar intervertebral discs (LDD). Magnetic resonance imaging (MRI) is the current best tool to visualize and diagnose LDD, but places high time demands on clinical radiologists. Automated reading of spine MRIs could improve speed, accuracy, reliability and cost effectiveness in radiology departments. The aim of this review and meta-analysis was to determine if current machine learning algorithms perform well identifying disc degeneration, herniation, bulge and Modic change compared to radiologists.

Methods

A PRISMA systematic review protocol was developed and four electronic databases and reference lists were searched. Strict inclusion and exclusion criteria were defined. A PROBAST risk of bias and applicability analysis was performed.

Results

1350 articles were extracted. Duplicates were removed and title and abstract searching identified original research articles that used machine learning (ML) algorithms to identify disc degeneration, herniation, bulge and Modic change from MRIs. 27 studies were included in the review; 25 and 14 studies were included multi-variate and bivariate meta-analysis, respectively. Studies used machine learning algorithms to assess LDD, disc herniation, bulge and Modic change. Models using deep learning, support vector machine, k-nearest neighbors, random forest and naïve Bayes algorithms were included. Meta-analyses found no differences in algorithm or classification performance. When algorithms were tested in replication or external validation studies, they did not perform as well as when assessed in developmental studies. Data augmentation improved algorithm performance when compared to models used with smaller datasets, there were no performance differences between augmented data and large datasets.

Discussion

This review highlights several shortcomings of current approaches, including few validation attempts or use of large sample sizes. To the best of the authors' knowledge, this is the first systematic review to explore this topic. We suggest the utilization of deep learning coupled with semi- or unsupervised learning approaches. Use of all information contained in MRI data will improve accuracy. Clear and complete reporting of study design, statistics and results will improve the reliability and quality of published literature.
Artificial intelligence in diabetic retinopathy screening: clinical assessment using handheld fundus camera in a real-life setting
Authors: Lupidi Marco , Danieli Luca , Fruttini Daniela , Nicolai Michele , Lassandro Nicola , Chhablani Jay , Mariotti Cesare
Published: May 2023

Aim

Diabetic retinopathy (DR) represents the main cause of vision loss among working age people. A prompt screening of this condition may prevent its worst complications. This study aims to validate the in-built artificial intelligence (AI) algorithm Selena+ of a handheld fundus camera (Optomed Aurora, Optomed, Oulu, Finland) in a first line screening of a real-world clinical setting.

Methods

It was an observational cross-sectional study including 256 eyes of 256 consecutive patients. The sample included both diabetic and non-diabetic patients. Each patient received a 50°, macula centered, non-mydriatic fundus photography and, after pupil dilation, a complete fundus examination by an experienced retina specialist. All images were after analyzed by a skilled operator and by the AI algorithm. The results of the three procedures were then compared.

Results

The agreement between the operator-based fundus analysis in bio-microscopy and the fundus photographs was of 100%. Among the DR patients the AI algorithm revealed signs of DR in 121 out of 125 subjects (96.8%) and no signs of DR 122 of the 126 non-diabetic patients (96.8%). The sensitivity of the AI algorithm was 96.8% and the specificity 96.8%. The overall concordance coefficient k (95% CI) between AI-based assessment and fundus biomicroscopy was 0.935 (0.891–0.979).

Conclusions

The Aurora fundus camera is effective in a first line screening of DR. Its in-built AI software can be considered a reliable tool to automatically identify the presence of signs of DR and therefore employed as a promising resource in large screening campaigns.
Enabling same-day delivery using a drone resupply model with transshipment points
Authors: Moshref-Javadi Mohammad , Van Cauwenberghe Kristof P. , McCunney Brent A. , Hemmati Ahmad
Published: May 2023

We study a hybrid logistics delivery model which incorporates trucks and drones. In this model, named the Drone Resupply Model with Transshipment Points (DRMTP), drones are used to resupply transshipment points where trucks visit to pick up packages for delivery to customers. A simulation model is developed to simulate the delivery operations. The model is evaluated in two case studies in an urban area and a suburban area in Massachusetts, USA. Using this resupply model, the average delivery time is reduced compared to the conventional truck-only delivery model. The experimental results in the suburban region show that the DRMTP model with one transshipment point achieves 36% lower delivery time compared to the truck-only model. In the urban region, the model with four transshipment points obtains 66% delivery time reduction compared to the truck-only model. The results indicate that the proposed model can be used to enhance the efficiency of the last-mile delivery operations.
Cortical and Subcortical Changes in MEG Activity Reflect Parkinson’s Progression over a Period of 7 Years
Authors: Boon Lennard I. , Hillebrand Arjan , Schoonheim Menno M. , Twisk Jos W. , Stam Cornelis J. , Berendse Henk W.
Published: May 2023

In this study of early functional changes in Parkinson’s disease (PD), we aimed to provide a comprehensive assessment of the development of changes in both cortical and subcortical neurophysiological brain activity, including their association with clinical measures of disease severity. Repeated resting-state MEG recordings and clinical assessments were obtained in the context of a unique longitudinal cohort study over a seven-year period using a multiple longitudinal design. We used linear mixed-models to analyze the relationship between neurophysiological (spectral power and functional connectivity) and clinical data. At baseline, early-stage (drug-naïve) PD patients demonstrated spectral slowing compared to healthy controls in both subcortical and cortical brain regions, most outspoken in the latter. Over time, spectral slowing progressed in strong association with clinical measures of disease progression (cognitive and motor). Global functional connectivity was not different between groups at baseline and hardly changed over time. Therefore, investigation of associations with clinical measures of disease progression were not deemed useful. An analysis of individual connections demonstrated differences between groups at baseline (higher frontal theta, lower parieto-occipital alpha2 band functional connectivity) and over time in PD patients (increase in frontal delta and theta band functional connectivity). Our results suggest that spectral measures are promising candidates in the search for non-invasive markers of both early-stage PD and of the ongoing disease process.
Oridonin attenuates the progression of atherosclerosis by inhibiting NLRP3 and activating Nrf2 in apolipoprotein E-deficient mice
Authors: Wang Lei , Zhao Xiaoqi , Ding Jiawen , Liu Yutong , Liu Han , Zheng Lei , Zhao Hongting , Sun Zichen , Li Kuanyu , Cai Jing , Qiao Tong
Published: May 2023

Oridonin, a well-known traditional Chinese herbal medicinal product isolated from Isodon rubescens (Hemsl.) H.Hara, has many potential properties, including anti-inflammatory and antioxidant activities. However, there is no evidence whether oridonin have a protective effect on atherosclerosis. This study focused on the effects of oridonin on oxidative stress and inflammation generated from atherosclerosis. The therapeutic effect on atherosclerosis was evaluated by intraperitoneal injection of oridonin in a high-fat fed ApoE−/− mouse model. We isolated mouse peritoneal macrophages and detected the effect of oridonin on oxidized low-density lipoprotein-induced lipid deposition. Oil red O staining, Masson's staining, dihydroethidium fluorescence staining, immunohistochemical staining, western blotting analysis, immunofluorescence, enzyme-linked immunosorbent assay and quantitative real-time PCR were used to evaluate the effect on atherosclerosis and explore the mechanisms. Oridonin treatment significantly alleviated the progression of atherosclerosis, reduced macrophage infiltration and stabilized plaques. Oridonin could significantly inhibit inflammation associated with NLRP3 activation. Oridonin significantly reduced oxidative stress by blocking Nrf2 ubiquitination and degradation. We also found that oridonin could prevent the formation of foam cells by increasing lipid efflux protein and reducing lipid uptake protein in macrophages. Oridonin has a protective effect on atherosclerosis in ApoE−/− mice, which may be related to the inhibition of NLRP3 and the stabilization of Nrf2. Therefore, oridonin may be a potential therapeutic agent for atherosclerosis.
Guilt, Shame and Academic Misconduct
Authors: Curtis Guy J.
Published: May 2023

Moral and self-conscious emotions like guilt and shame can function as internal negative experiences that punish or deter bad behaviour. Individual differences exist in people’s tendency to experience guilt and shame. Being disposed to experience guilt and/or shame may predict students’ expectations of their emotional reactions to engaging in immoral behaviour in the form of academic misconduct, and thus dissuade students from intending to engage in this behaviour. In this study, students’ (n = 459) guilt and shame proneness, their expectations of feeling guilt and shame if they engaged in academic misconduct, and their intentions to engage in academic misconduct were measured. Three of the four facets of the guilt and shame proneness scale [GASP: Guilt–Negative-Behavior-Evaluation (NBE), Guilt-Repair, Shame–Negative-Self-Evaluation (NSE)] had significant negative correlations with academic misconduct intentions, and these relationships were mediated by anticipating shame and guilt related to engaging in academic misconduct. These results suggest that for some students expecting to experience negative moral emotions when engaging in academic misconduct may protect them from breaching ethical assessment rules.
Determining the degree of crystallization of aripiprazole during cold crystallization using thermo-optical analysis and differential scanning calorimetry
Authors: Osiecka-Drewniak N. , Juszyńska-Gałązka Ewa
Published: May 2023

The full characteristic of the crystallization process of aripiprazole crystal is given. Our research reveals that a degree of crystallinity calculated from the analyses of data of light intensity passing through the sample (Thermo-Optical Analysis based on Polarized Light Microscopy—POM), the Canny edge detection algorithm, and Differential Scanning Calorimetry—DSC, are in good agreement. The parameters of Avrami model, the dimensionality of the crystal growth, and the characteristic crystallization temperature, obtained from POM and DSC methods coincide. The obtained values of the Avrami exponent n suggest that the crystal growth is three-dimensional.
RETRACTED ARTICLE: MiR-125 family improves the radiosensitivity of head and neck squamous cell carcinoma
Authors: Wang Qi-Wei , Sun Ya-Nan , Tan Li-Jun , Zhao Jian-Nan , Zhou Xiao-Jie , Yu Tian-Jiao , Liu Jiang-Tao
Published: May 2023

Background

MiRNAs can affect the radiosensitization of head and neck squamous cell carcinoma (HNSCC). We aimed to analyze the function of miR-125 family members in HNSCC using The Cancer Genome Atlas (TCGA) and determine their effect on radiation in laryngeal squamous cell cancer (LSCC).

Methods

First, we systematically analyzed the role of the miR-125 family in HNSCC using the TCGA database and found that miR-125a-5p is associated with radiotherapy. We then performed comprehensive enrichment analysis of miR-125a-5p and predicted target genes. Then, we performed transfection, cell proliferation assays, reverse transcription polymerase chain reaction, apoptosis assays, micronucleus tests, and western blotting on hep-2 cells selected with puromycin.

Results

MiR-125 family members exhibited significantly different expression in HNSCC. They were significantly associated with tumor–node–metastasis staging, clinical stages, and histological grades. Radiation therapy had a statistically effect on miR-125 family members, except miR-125a-3p. Moreover, miR-125a-5p was related to overall survival in LSCC. Thus, we predicted 110 target genes and seven hub genes of miR-125a-5p. The proliferation rate of cells transfected with lentivirus vector expressing miR-125a-5p was significantly reduced compared to the other groups. The radiation effect was enhanced in cells transfected with miR-125a-5p. The ratio of apoptotic cells transfected and exposed to X-rays (10 Gy) was distinctly higher than that of the Ad-control group. Western blotting analysis revealed that miR-125a-5p upregulated the apoptotic regulators P53 and rH2AX. Thus, miR-125a-5p may increase radiosensitivity in LSCC via upregulation of pro-apoptotic genes.

Conclusions

MiR-125 family members could be prognostic biomarkers of HNSCC and improve HNSCC sensitivity to radiotherapy by activating P53. Upregulating miR-125a-5p via lentivirus vectors may be a novel strategy to strengthen the effect of radiotherapy on LSCC.
Versatile end effector for laparoscopic robotic scrub nurse
Authors: Wagner Lars , Kolb Sven , Looschen Christian , Bernhard Lukas , Fuchtmann Jonas , Berlet Maximilian , Fottner Johannes , Knoll Alois , Wilhelm Dirk
Published: May 2023

Purpose

Integrating robotic scrub nurses in the operating room has the potential to help overcome staff shortages and limited use of available operating capacities in hospitals. Existing approaches of robotic scrub nurses are mainly focused on open surgical procedures, neglecting laparoscopic procedures. Laparoscopic interventions offer great potential for the context-sensitive integration of robotic systems due to possible standardization. However, the first step is to ensure the safe manipulation of laparoscopic instruments.

Methods

A robotic platform with a universal gripper system was designed to pick up and place laparoscopic as well as da Vinci$$^{\circledR }$$

®

instruments in an efficient workflow. The robustness of the gripper system was studied using a test protocol, which included a force absorption test to determine the operational safety limits of the design and a grip test to determine the system performance.

Results

The test protocol shows results regarding force and torque absorption capabilities of the end effector, which are essential when transferring an instrument to the surgeon to enable a robust handover. The grip tests show that the laparoscopic instruments can be safely picked up, manipulated and returned independent of unexpected positional deviations. The gripper system also enables the manipulation of da Vinci$$^{\circledR }$$

®

instruments, opening the door for robot–robot interaction.

Conclusion

Our evaluation tests have shown that our robotic scrub nurse with the universal gripper system can safely and robustly manipulate laparoscopic and da Vinci$$^{\circledR }$$

®

instruments. The system design will continue with the integration of context-sensitive capabilities.
Novel Approaches in the Management of Mucormycosis
Authors: Lamoth Frederic
Published: May 2023

Purpose of Review

Invasive mucormycosis (IM), caused by fungi of the order Mucorales, is one of the deadliest fungal infection among hematologic cancer patients. Its incidence is also increasingly reported in immunocompetent individuals, notably with the COVID-19 pandemic. Therefore, there is an urgent need for novel diagnostic and therapeutic approaches of IM. This review discusses the current advances in this field.

Recent Findings

Early diagnosis of IM is crucial and can be improved by Mucorales-specific PCR and development of lateral-flow immunoassays for specific antigen detection. The spore coat proteins (CotH) are essential for virulence of the Mucorales and may represent a target for novel antifungal therapies. Adjuvant therapies boosting the immune response, such as interferon-γ, anti-PDR1 or fungal-specific chimeric antigen receptor (CAR) T-cells, are also considered.

The most promising perspectives for improved management of IM consist of a multilayered approach targeting both the pathogen and the host immune system.
Does enrolling in finance-related majors improve financial habits? A case study of China’s college students
Authors: Huang Wei , Liao Xiaowei , Li Fan , Yao Panpan
Published: May 2023

There is a growing awareness of the importance of financial management skills. However, few studies have systematically examined this topic in China’s current higher education (HE) system. In this study, we examine whether enrolling in a finance-related program, either as a degree program or as an elective, improves students’ financial literacy and habits. We conducted a mixed-method study with a sample of 1334 students from seven universities in central China. Multivariate regression, matching methods, and the inverse–probability–weighting methods were used for quantitative analysis. The results indicate that college students are generally dissatisfied with their financial situation. Enrolling in finance-related majors has little effect on improving students’ financial habits, despite a substantial improvement in their financial literacy. In the current HE system, there is a significant lack of personal finance management training. Therefore, curriculum design and field practices regarding students’ personal finance management skills should be introduced to enhance their financial habits.
Formative assessment in maritime simulator-based higher education
Authors: Karahalil Meric , Lützhöft Margareta , Scanlan Joel
Published: May 2023

Assessment in maritime simulator-based education has traditionally been informal and subjective based on instructor experience. Recent research suggests that a more objective and formal approach could be beneficial. Formative assessment has attracted significant attention from higher education institutions. Thus, this study aimed to examine the current practice of formative assessment in maritime simulator-based education, with a special emphasis on simulator instructors’ teaching methods. A qualitative approach with observations and interviews was used in the study since it could provide deep insights into educators’ motivations and understandings of how to meet the educational needs of their students. The findings inform the formative assessment strategies may explicitly enhance maritime education.
A spatial–spectral adaptive learning model for textile defect images recognition with few labeled data
Authors: Zhang Yuan , Han Tao , Wei Bing , Hao Kuangrong , Gao Lei
Published: May 2023

Textile defect recognition is a significant technique in the production processes of the textile industry. However, in the practical processes, it is hard to acquire large amounts of textile defect samples. Meanwhile, the textile samples with correct defect labels are rare. To address these two limitations, in this paper, we propose a novel semi-supervised graph convolutional network for few labeled textile defect recognition. First, we construct the graph convolutional network and convolution neural network to extract spectral features and spatial features. Second, the adaptive convolution structure is proposed to generate adaptive kernels according to their dynamically learned features. Finally, the spatial–spectral adaptive unified learning network (SSA-ULNet) is built for limited labeled defective samples, and graph-based semi-supervised learning is constructed. The textile defect recognition model can extract the textile image features through the image descriptors, enabling the whole network to be end-to-end trainable. To evaluate the proposed method, one public dataset and two unique self-built textile defect datasets are used to textile defect recognition. The evaluation results demonstrate that the proposed SSA-ULNet obviously outperforms existing state-of-the-art deep learning methods.
Learning spatio-temporal discriminative model for affine subspace based visual object tracking
Authors: Xu Tianyang , Zhu Xue-Feng , Wu Xiao-Jun
Published: May 2023

Discriminative correlation filters (DCF) with powerful feature descriptors have proven to be very effective for advanced visual object tracking approaches. However, due to the fixed capacity in achieving discriminative learning, existing DCF trackers perform the filter training on a single template extracted by convolutional neural networks (CNN) or hand-crafted descriptors. Such single template learning cannot provide powerful discriminative filters with guaranteed validity under appearance variation. To pinpoint the structural relevance of spatio-temporal appearance to the filtering system, we propose a new tracking algorithm that incorporates the construction of the Grassmannian manifold learning in the DCF formulation. Our method constructs the model appearance within an online updated affine subspace. It enables joint discriminative learning in the origin and basis of the subspace, achieving enhanced discrimination and interpretability of the learned filters. In addition, to improve tracking efficiency, we adaptively integrate online incremental learning to update the obtained manifold. To this end, specific spatio-temporal appearance patterns are dynamically learned during tracking, highlighting relevant variations and alleviating the performance degrading impact of less discriminative representations from a single template. The experimental results obtained on several well-known datasets, i.e., OTB2013, OTB2015, UAV123, and VOT2018, demonstrate the merits of the proposed method and its superiority over the state-of-the-art trackers.
Warrior Women
Authors: Fell Alison S.
Published: May 2023

This Element examines women warriors as vehicles of mobilisation. It argues that women warrior figures from the mid-nineteenth century until the end of the Second World War are best understood as examples of 'palimpsestic memory', as the way they were represented reflected new contexts while retaining traces of legendary models such as Joan of Arc, and of 'travelling memory', as their stories crossed geographical borders and were re-told and re-imagined. It considers both the instrumentalisation of women warriors by state actors to mobilise populations in the world wars, and by non-state actors in resistance, anti-colonial and feminist movements. Fell's analysis of a broad range of global conflicts helps us to understand who these actors were, what motivated them, and what meanings armed women embodied for them, enabling a fresh understanding of the woman warrior as an archetype in modern warfare.
Medieval Textiles across Eurasia, c. 300–1400
Authors: Blessing Patricia , Williams Elizabeth Dospěl , Shea Eiren L.
Published: May 2023

This study considers the textiles made, traded, and exchanged across Eurasia from late antiquity to the late Middle Ages with special attention to the socio-political and cultural aspects of this universal medium. It presents a wide range of textiles used in both domestic and religious settings, as dress and furnishings, and for elite and ordinary owners. The introduction presents historiographical background to the study of textiles and explains the conditions of their survival in archaeological contexts and museums. A section on the materials and techniques used to produce textiles if followed by those outlining textile production, industry, and trade across Eurasia. Further sections examine the uses for dress and furnishing textiles and the appearance of imported fabrics in European contexts, addressing textiles' functions and uses in medieval societies. Lastly, a concluding section on textile aesthetics connects fabrics to their broader visual and material context.
Macadamia nut effects on cardiometabolic risk factors: a randomised trial
Authors: Jones Julie L. , Sabaté Joan , Heskey Celine , Oda Keiji , Miles Fayth , Rajaram Sujatha
Published: May 2023

We sought to examine the effects of daily consumption of macadamia nuts on body weight and composition, plasma lipids and glycaemic parameters in a free-living environment in overweight and obese adults at elevated cardiometabolic risk. Utilising a randomised cross-over design, thirty-five adults with abdominal obesity consumed their usual diet plus macadamia nuts (~15 % of daily calories) for 8 weeks (intervention) and their usual diet without nuts for 8 weeks (control), with a 2-week washout. Body composition was determined by bioelectrical impedance; dietary intake was assessed with 24-h dietary recalls. Consumption of macadamia nuts led to increased total fat and MUFA intake while SFA intake was unaltered. With mixed model regression analysis, no significant changes in mean weight, BMI, waist circumference, percent body fat or glycaemic parameters, and non-significant reductions in plasma total cholesterol of 2⋅1 % (−4⋅3 mg/dl; 95 % CI −14⋅8, 6⋅1) and low-density lipoprotein (LDL-C) of 4 % (−4⋅7 mg/dl; 95 % CI −14⋅3, 4⋅8) were observed. Cholesterol-lowering effects were modified by adiposity: greater lipid lowering occurred in those with overweight v. obesity, and in those with less than the median percent body fat. Daily consumption of macadamia nuts does not lead to gains in weight or body fat under free-living conditions in overweight or obese adults; non-significant cholesterol lowering occurred without altering saturated fat intake of similar magnitude to cholesterol lowering seen with other nuts.

Clinical Trial Registry Number and Website: NCT03801837 https://clinicaltrials.gov/ct2/show/NCT03801837?term = macadamia + nut&draw = 2&rank = 1
Extra-territoriality and the UK Insolvency Act 1986
Authors: McCormack Gerard
Published: May 2023

This paper considers whether UK corporate insolvency law and the UK Insolvency Act 1986 have extra-territorial effect post-Brexit, and whether – and to what extent – it is for the courts or the legislature to extend any extra-territorial effect. It does not deal with ‘inward recognition’, ie the recognition of foreign judgments and orders in the UK.

Brexit has left something of a vacuum and provisions which might otherwise have applied extra-territorially, at least within the EU, may now have been deprived completely of extra-territorial effect. But all is not lost and Brexit here presents opportunities. There is room for clarifying that particular provisions which might otherwise have discriminated between EU application and application vis-à-vis the rest of the world can now be given a uniform global interpretation. Courts should, however, proceed incrementally in extending the extra-territorial scope of UK corporate insolvency law.

A bolder reform would be to enact legislation that specifies the exact extent to which the UK Insolvency Act applies extra-territorially. Legislation obviously depends on parliamentary time and requires detailed drafting but also provides the opportunity for the UK to showcase that it remains at the forefront of international insolvency developments.
Heightened fearfulness in infants is not adaptive
Authors: Ogren Marissa , Barrett Lisa Feldman , Hoemann Katie , LoBue Vanessa
Published: May 2023

Grossmann proposes the “fearful ape hypothesis,” suggesting that heightened fearfulness in early life is evolutionarily adaptive. We question this claim with evidence that (1) perceived fearfulness in children is associated with negative, not positive long-term outcomes; (2) caregivers are responsive to all affective behaviors, not just those perceived as fearful; and (3) caregiver responsiveness serves to reduce perceived fearfulness.
Hominin life history, pathological complexity, and the evolution of anxiety
Authors: Veit Walter , Browning Heather
Published: May 2023

In order to address why the number of patients suffering from anxiety and depression are seemingly exploding in Western, educated, industrialized, rich, and democratic (WEIRD) countries, it is sensible to look at the evolution of human fearfulness responses. Here, we draw on Veit's pathological complexity framework to advance Grossmann's goal of re-characterizing human fearfulness as an adaptive trait.
When radical uncertainty is too much: Clinical aspects of Conviction Narrative Theory
Authors: Linkovski Omer , Eitan Renana
Published: May 2023

We propose extrapolating Conviction Narrative Theory (CNT) to clinical psychology and psychiatry. We demonstrate how CNT principles may benefit assessment, therapy, and possibly even modify public health views of neuropsychiatric disorders. Our commentary focuses on hoarding disorder as a model, elaborates on discrepancies in the scientific literature and suggests how the CNT may resolve them.
The statistical mechanics of felt uncertainty under active inference
Authors: Solms Mark
Published: May 2023

Convincing narratives are not confabulations. Presumably they “feel right” to decision-making agents because the probabilities they assign intuitively (i.e., implicitly) to potential outcomes are plausible. Can we render explicit the calculations that would be performed by a decision-making agent to evaluate the plausibility of competing narratives? And if we can, what, exactly, makes a narrative “feel right” to an agent?
Narratives, probabilities, and the currency of thought
Authors: Johnson Samuel G. B. , Bilovich Avri , Tuckett David
Published: May 2023

Whereas most commentators agree about the centrality of narratives in decision-making, the commentaries revealed little consensus about the nature of radical uncertainty. Here we consider thirteen objections to our views, including our characterization of the uncertain decision environment and associated cognitive, affective, and social processes. We conclude that under radical uncertainty, narratives rather than probabilities are the currency of thought.
Loneliness is associated with mentalizing and emotion recognition abilities in schizophrenia, but only in a cluster of patients with social cognitive deficits
Authors: Okruszek Ł. , Jarkiewicz M. , Piejka A. , Chrustowicz M. , Krawczyk M. , Schudy A. , Harvey P. D. , Penn D. L. , Ludwig K. , Green M. F. , Pinkham A. E.
Published: May 2023

Objective:

Loneliness is a concern for patients with schizophrenia. However, the correlates of loneliness in patients with schizophrenia are unclear; thus, the aim of the study is to investigate neuro- and social cognitive mechanisms associated with loneliness in individuals with schizophrenia.

Method:

Data from clinical, neurocognitive, and social cognitive assessments were pooled from two cross-national samples (Poland/USA) to examine potential predictors of loneliness in 147 patients with schizophrenia and 103 healthy controls overall. Furthermore, the relationship between social cognition and loneliness was explored in clusters of patients with schizophrenia differing in social cognitive capacity.

Results:

Patients reported higher levels of loneliness than healthy controls. Loneliness was linked to increased negative and affective symptoms in patients. A negative association between loneliness and mentalizing and emotion recognition abilities was found in the patients with social-cognitive impairments, but not in those who performed at normative levels.

Conclusions:

We have elucidated a novel mechanism which may explain previous inconsistent findings regarding the correlates of loneliness in individuals with schizophrenia.
Submitting toPolitics & Gender: Advice from the Editors
Authors: Franceschet Susan , Krook Mona Lena , Wolbrecht Christina
Published: May 2023

For nearly 20 years,Politics & Genderhas been a leading outlet for research on women, gender, and politics. As past and current editors,1we are happy to share our advice for early career researchers interested in submitting manuscripts to the journal. We believe that as the official journal of the Women, Gender, and Politics Section of the American Political Science Association, the content ofPolitics & Gendershould reflect the diversity of authors, methods, and topics found across the broader gender and politics research community. However, not all authors have the full information on how to best prepare their manuscripts—or, indeed, what to expect during different parts of the review process (see Anlar and Phillips 2023).
The Weight of New York City: Possible Contributions to Subsidence From Anthropogenic Sources
Authors: Parsons Tom , Wu Pei‐Chin , (Matt) Wei Meng , D'Hondt Steven
Published: May 2023

New York City faces accelerating inundation risk from sea level rise, subsidence, and increasing storm intensity from natural and anthropogenic causes. Here we calculate a previously unquantified contribution to subsidence from the cumulative mass and downward pressure exerted by the built environment of the city. We enforce that load distribution in a multiphysics finite element model to calculate expected subsidence. Complex surface geology requires multiple rheological soil models to be applied; clay rich soils and artificial fill are calculated to have the highest post‐construction subsidence as compared with more elastic soils. Minimum and maximum calculated building subsidence ranges from 0 to 600 mm depending on soil/rock physical parameters and foundation modes. We compare modeled subsidence and surface geology to observed subsidence rates from satellite data (Interferometric Synthetic Aperture Radar and Global Positioning System). The comparison is complicated because the urban load has accumulated across a much longer period than measured subsidence rates, and there are multiple causes of subsidence. Geodetic measurements show a mean subsidence rate of 1–2 mm/year across the city that is consistent with regional post‐glacial deformation, though we find some areas of significantly greater subsidence rates. Some of this deformation is consistent with internal consolidation of artificial fill and other soft sediment that may be exacerbated by recent building loads, though there are many possible causes. New York is emblematic of growing coastal cities all over the world that are observed to be subsiding (Wu et al., 2022, https://doi.org/10.1029/2022GL098477), meaning there is a shared global challenge of mitigation against a growing inundation hazard.
Oblique Blind Faulting Underneath the Luzon Volcanic Arc During the 2022 Mw 7.0 Abra Earthquake, the Philippines
Authors: Tang Chi‐Hsien , Hsu Ya‐Ju , Bacolcol Teresito , Lin Yunung Nina , Chen Horng‐Yue , Kuo Yu‐Ting , Su Hsuan‐Han , Lee Hsin‐Ming , Pelicano Alfie , Sapla Genesis , Yu Shui‐Beih
Published: May 2023

Unknown seismogenic structures lurking beneath convergent margins introduce substantial uncertainty in seismic hazard assessments. In northwestern Luzon, the Mw 7.0 Abra earthquake on 27 July 2022 highlights the seismic activity along an unmapped blind fault underneath the Cordillera Central. By integrating coseismic displacements constrained by radar satellite imagery and Global Navigation Satellite System, we image oblique coseismic slip at 11–22 km depth with peak slip of ∼1 m beneath the Philippine Fault Zone in northern Luzon. The southward propagation of coseismic slip and aftershocks terminated at a distance of 50 km from the northern end of the 1990 Luzon earthquake rupture, leaving a seismicity gap in between. Coulomb stress changes of reaching 2 bars are imparted at the shallow portions of the Vigan‐Aggao and Abra River faults, where the updated 100‐year seismic potential is increased to Mw 7.0–7.7, given the thick seismogenic layer of ∼30 km in northern Luzon.
Numerical Investigation of the Influence of Hydrodynamic Dispersion on Solutal Natural Convection
Authors: Tsinober Avihai , Shavit Uri , Rosenzweig Ravid
Published: May 2023

We investigate numerically the effect of hydrodynamic dispersion on convective dissolution of carbon dioxide in saline aquifers. Solutions of the transport equations were used to describe the dissolution process in the aquifer and provide a systematic parametric analysis of the influence of dispersion on two important measures of convective dissolution, the wavenumber, and dissolution flux. The results suggest that dispersion decreases the dissolution rate and reduces the finger wavenumber. Based on the simulated results, new empirical scaling laws that predict the dissolution rate and wavenumber were developed. The application of the new laws to two storage sites shows that the currently available predictions overestimate the dissolution rates by ∼30%. We have identified some discrepancies between published scaling laws that were obtained for the dissolution rate. While most numerical studies identify a linear scaling, experimental investigations often suggest a sublinear behavior. Our findings resolve the controversy by suggesting that dispersion, which was not considered in these past numerical studies, is the reason for the apparent sublinear scaling.
Nanomechanical hydrodynamic force sensing using suspended microfluidic channels
Authors: Martín-Pérez Alberto , Ramos Daniel
Published: May 2023

Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic forces. However, there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing particle. In this work, we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators (SMRs). This hydrodynamic force sensitivity depends on the device used; therefore, we considered the geometry and materials to advance this dependency on the SMR resonance frequency.