bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of SARS-CoV-2 infections in patients with cancer on mortality, ICU admission and incidence: A systematic review with meta-analysis involving 709.908 participants and 31.732 cancer patients
Authors: Arayici Mehmet Emin , Kipcak Nazlican , Kayacik Ufuktan , Kelbat Cansu , Keskin Deniz , Kilicarslan Muhammed Emin , Kilinc Ahmet Veli , Kirgoz Sumeyye , Kirilmaz Anil , Kizilkaya Melih Alihan , Kizmaz Irem Gaye , Kocak Enes Berkin , Kochan Enver , Kocpinar Begum , Kordon Fatmanur , Kurt Batuhan , Ellidokuz Hulya
Published: May 2022

Background
Cancer patients constitute one of the highest-risk patient groups during the COVID-19 pandemic. In this study, it was aimed to perform a systematic review and meta-analysis to determine both the incidence and ICU (Intensive Care Unit) admission rates and mortality in SARS-CoV-2 infected cancer patients.
Methods
The PRISMA guidelines were closely followed during the design, analysis, and reporting of this systematic review and meta-analysis. A comprehensive literature search was performed for the published papers in PubMed / Medline, Scopus, medRxiv, Embase, and Web of Science (WoS) databases. SARS-CoV-2 infection pooled incidence in the cancer populations and the risk ratio (RR) of ICU admission rates / mortality in cancer and non-cancer groups, with 95% confidence intervals (CIs), were calculated using the random-effects model.
Results
A total of 58 studies, involving 709.908 participants and 31.732 cancer patients, were included in this study. The incidence in cancer patients was calculated as 8% (95% CI: 8% − 9%). Analysis results showed that mortality and ICU admission rate was significantly higher in patients with cancer (RR = 2.26, 95% CI: 1.94– 2.62, P < 0.001; RR = 1.45, 95% CI: 1.28–1.64, p < 0.001, respectively).
Conclusion
As a result, cancer was an important comorbidity and risk factor for all SARS-CoV-2 infected patients. This infection could result in severe and even fatal events in cancer patients. Cancer is associated with a poor prognosis in the COVID-19 pandemic. Cancer patients should be assessed more sensitively in the COVID-19 outbreak.
Tri-tert-bütilanilin Temelinde Yeni Sterik Engelli Salisilaldiminlerin Cu(II) Komplekslerinin Sentezi ve Karakterizasyonu
Authors: AYTAR Emine , HARTAVİ Sümeya , KASIM Veli
Published: May 2022

Primer aminler ile karbonil bileşiklerinin reaksiyonundan oluşan Schiff bazları yaygın bir şekilde ligant olarak kullanılan maddelerdir. Schiff bazları aminotiyoller, o- amino fenoller, α-amino asitler ve aminoalkollerin asetil aseton veya salisilaldehit katılması ile oluşturulabilir. Ligant olarak koordinasyon bileşiklerinin sentezinde geniş bir kullanım alanına sahip olan Schiff bazları ile birçok bilim insanı ilgilenmiş ve faklı bileşikler elde etmişlerdir. Schiff bazları endüstri, tıp, eczacılık, boya endüstrisi, tekstil sektörü gibi kimyanın pek çok alanında uygulama imkanı bulabilen bileşiklerdir. Özellikle biyokimya ve analitik kimya uygulamaları oldukça dikkat çekicidir. Eser element olan bakırın sağlık alanındaki rolü ve bakır komplekslerinin bilinen bir çok biyolojik aktiviteleri nedeniyle, Schiff bazı ligandları ile oluşturulan Cu(II) komplekslerinin fiziksel ve kimyasal davranışlarının incelenmesi oldukça önemlidir. Bu nedenle bu çalışmada; 2,4,6-tri-tert-butilanilin ile 3,5-di-tert-butil-2-hidroksibenzaldehit, 3-tert-butil-2-hidroksibenzaldehit ve 5-tert-butil-2-hidroksibenzaldehit reaksiyonundan yeni sterik engelli 3 adet salisilaldimin ligandı sentezlendi. Daha sonra elde edilen bu ligandların Cu(II) tuzu ile reaksiyonundan iki adet Cu(II) kompleksi olmak üzere toplam üç ligand ve iki metal kompleks sentezlendi. Sentezlenen tri-tert-butilanilin temelli yeni sterik engelli salisilaldimin ligand ve metal komplekslerinin yapıları, erime noktası, UV-Vis, FT-Ir, elementel analiz, manyetik süseptibilite, 1H NMR ve 13C NMR ile karakterize edildi.
The Short Channel and Quantum Confinement Effects on Transfer Characteristics of Si NWMOSFET Depending on the Gate Length and Temperature
Authors: GENÇ İbrahim , IPEK Semran
Published: May 2022

With advancements in nanomaterial synthesis, semiconductor device technology entered a new era with nanotechnology. In fact, quantum effects such as confinement and tunneling have played a significant role in device characteristics. In this work, we have investigated quantum ballistic transport properties of Si nanowire MOSFET (Si NWMOSFET) with 4 nm gate length. Since gate length is shorter than the electron wavelength in our Si NWMOSFET, ballistic transport in one dimension (1D) is expected to be the dominant mechanism for carrier transport. Therefore, the parameters which are crucial for efficient MOSFET operation such as gate length, temperature, gate voltage have been simulated using the density gradient method to present quantum confinement effect on device transfer characteristics. We have found that Si NWMOSFET has an I_on/I_off ratio > 10^8, which is close to ideal value for similar nano MOSFETs. Moreover, due to short channel, intersubband scattering can deteriorate 1D ballistic transport properties of Si NWMOSFET, especially in low temperatures.
Comparative study for assessing vulnerability to pollution in El Asnam plain, North of Algeria
Authors: Rezig Amina , Marinangeli Lucia , Saggai Sofiane
Published: May 2022

Assessment of groundwater contamination is an efficient means to discover and carry out the demarcation of the more vulnerable zones to pollution from human activities. This study is focused on the plain of El Asnam (Northern Algeria) characterized by intensive agricultural activities. To protect the groundwater from pollution, it is necessary to determine vulnerable areas. This paper aims to generate groundwater vulnerability map using two models: DRASTIC and Susceptibility Index (SI) associated with the geographic information system (GIS) of El Asnam plain aquifer. The validation of these models to pollution was performed by comparing the nitrate distribution across the area with the classes of vulnerability and has proved that the SI model is the more valid one with 50% of the study area. Considering these results, the SI model may serve as an effective means to help the protection of groundwater and can eventually be used by decision makers and groundwater managers.
Equilibrium simulation and driving factors of dissolved oxygen in a shallow eutrophic Inner Mongolian lake (UL) during open-water period
Authors: Zhang Fan , Shi Xiaohong , Zhao Shengnan , Arvola Lauri , Huotari Jussi , Hao Ruonan
Published: May 2022

A water quality monitoring buoy installed in the center of the eutrophic shallow lake Ulansuhai was used to explore the dissolved oxygen (DO) balance. A revised DO model for shallow eutrophic lakes was applied to identify trends in the lake's DO content during the non-frozen period and determine the equilibrium relationship of DO in the water body. The coefficient of determination and the Nash efficiency of the model proved the feasibility of the model. The main drivers affecting the DO balance of the lake were photosynthesis, aeration and the lateral movements of oxygen-rich water, which accounted for 49.28, 14.72 and 36%, respectively, whereas respiration and sediment oxygen consumption, on the other hand, accounted for 1.56 and 98.44%, respectively. These findings suggest that photosynthesis and sediment oxygen consumption dominate the DO balance in eutrophic shallow lakes. A trend analysis of the average oxygen production and consumption rates indicated a maximum of 0.22 mg/L·h for photosynthesis and 0.20 mg/L·h for sediment oxygen consumption. A correlation analysis showed that water temperature was involved in changing the DO level of the lake mainly by affecting the oxygen consumption process.
Nutraceuticals and Oral Supplements in Cancer Prevention: A Narrative
Review
Authors: De Pergola Giovanni , Marucci Simonetta , Corbo Filomena , Almerighi Guido , Cerutti Nadia , Triggiani Vincenzo , De Vito Danila , Castellana Fabio , Zupo Roberta
Published: May 2022

Background:

Epidemiological studies have shown that food is a compelling means of
maintaining a state of well-being and preventing diseases. Many malignant diseases are related to
nutrition, and the nutrient-organism interaction could define the balance between health and
disease. Nutrients and dietary components influence epigenetic phenomena and modify drug
response so that food-organism interactions may influence individual predisposition to disease and
its potential therapeutic response.

Aims:

In this review, we highlighted emerging opinions and data on a large cluster of
nutraceuticals, as well as functional foods and specific dietary patterns, with respect to cancer,
including breast, pancreas, prostate, and colorectal. Only those nutraceuticals and nutritional
supplements yielding sufficient and convincing data have been reported in this review; molecules
with inconclusive clinical evidence will not be discussed.

Conclusions:

Growing and accumulating evidence is validating the use of nutraceuticals in cancer
settings. However, a knowledge gap remains in terms of causal evidence for several compounds
where a window for further clinical studies is left.
Clinical Outcomes of Toric Implantable Collamer Lens (T-ICL) and Toric Implantable Phakic Contact Lens (IPCL) for High Myopia with Astigmatism: A Comparative Study
Authors: Mahmoud Mohamed Salah El-Din , AttaAllah Heba Radi
Published: May 2022

Background:

Our study aimed to compare the clinical, visual outcomes, and efficacy of toric Implantable Collamer Lens (T-ICL) and toric implantable phakic contact lens (IPCL) in patients with high myopia and astigmatism over a follow-up period of 6 months.

Methods:

A prospective interventional randomized comparative study included 60 myopic eyes divided into 2 groups, group A including 30 eyes that were implanted with T-ICL, and group B, including 30 eyes that were implanted with toric IPCL. The refractive results, visual acuity, central corneal endothelial cell count, and intraocular pressure (IOP) were evaluated at baseline and at 1 and 6 months post-surgery. Any complications either during or after surgery were assessed.

Results:

In both study groups, the mean central corneal endothelial cell count was significantly decreased after 1 month and improved to reach near pre-operative values after 6 months postoperatively, indicating good lens biocompatibility. A statistically significant increase in IOP was found in both groups during the early follow-up, and a significant decrease after 6 months postoperatively (p=0.036) was reported in group A. A significant reduction in both spherical and cylindrical refractive errors with good predictability was reported in both groups compared with pre-operative values. Regarding the predictability, In T-ICL group (A), the median spherical and cylindrical errors were significantly improved from (-10 D & -4.5 D) pre-operatively to (-0.3 D & - 0.3 D) at the end of 6 months follow up period. Similarly, in the toric IPCL group (B), the median spherical and cylindrical errors were significantly improved from (-11 D & -4.5 D) pre-operatively to (-0.3 D & - 0.3 D) by the end of follow up period. A statistically significant improvement of UCDVA at 6 months postoperatively was found in both groups, as median preoperative LogMAR UCDVA was 1.1 and 1.3 in groups A and B respectively, which was improved to 0.3 in both groups at the end of follow-up period. There were no reported intra- or postoperative complications such as cataract, keratitis, or lens decentration.

Conclusion:

Toric IPCL is a suitable alternative to T-ICL for the management of high myopia with astigmatism, especially in developing countries, as it is cheaper and easier to implant than T-ICL. However, data over longer follow-up periods are needed to confirm its safety and stability.
Pengaruh Pendidikan dan Pelatihan Serta Promosi Jabatan dalam Meningkatkan Kinerja Tenaga Kependidikan Non PNS
Authors: Dari Eva Wulan , Gani Abdul Juli Andi , Noor Irwan
Published: May 2022

Work performance is a crucial variable that remains relevant to be discusse asevery company is expected to have excellent performance. This study aims to investigate the effect of promotion, education, and training programs on the performance of non-civil servant academic in Faculty of Engineering, UB. This study implements a survey method with a quantitative approach and the research sample included 72 respondent,selected with non-probability sampling. Data were collected by questionnaire, which had previously been tested for validity and reliability. Hypotheses were tested using multiple regression. Based on the results, education and training, and promotions proved to have a significant effect on the performance of non-civil servant academic staff with 84.2% contribution. This finding is an important recommendation for the faculty to provide education and training programs regularly to maintain and improve employee competence. Furthermore, faculty may consider providing promotion programs to motivate the staff to dedicate their best performance.
Vivir entre violencias, desplazamiento y pandemia. jóvenes refugiados en el sur de México
Authors: Porraz Gómez Iván Francisco , Hernández López Rafael Alonso
Published: May 2022

En un contexto de inusitados cambios en las dinámicas migratorias en México, la frontera sur se ha convertido en un espacio de encuentros y desencuentros, de tensiones, pero también de muestras de solidaridad entre la población local y la extranjera proveniente de regiones como África, Asia, el Caribe, Sudamérica y, por supuesto, Centroamérica. A partir de contextualizar el origen del que huye la población desplazada, enfatizamos en las experiencias de vida que se desprenden de habitar temporalmente en una ciudad fronteriza como Tapachula, que históricamente ha tenido una dinámica de flujos laborales con la región centroamericana. Reflexionamos en torno a los impactos que ha tenido la pandemia en el control de la movilidad de las personas, generando una condición de inmovilidad que arrastra consigo una persistente vulnerabilidad, y con ello, el fortalecimiento de enfoques para la gestión migratoria altamente restrictivos, ahora justificados por motivos sanitarios.
Do peer attachment, perceived school climate, and parental involvement influence self-awareness in students?
Authors: Rachmah Dwi Nur , Putri Nathasya Inneke , Rizkika Rizkika , Magfirah Saidatul , Halimatussa’diah Siti
Published: May 2022

This study was aimed at investigating the effect of peer attachment, parental involvement, and perceived school climate on self-awareness in junior high school students in East Martapura, South Kalimantan Province, Indonesia. The quantitative research method through product moment correlation and multiple linear regression analysis was applied in this study. The sample of the research was the total population of a junior school in East Martapura with significant number of dropout cases. The subject of this study consisted of male and female students in the age of 11 to 17 years old with a family background of traders and farmers as well as a Malay-bajar Islamic culture. The results of the study showed that there was a significant correlation between peer attachment and parental involvement. In contrast, there was no correlation between both factors and perceived school climate. Furthermore, it was also found that there was a significant positive effect of peer attachment, parental involvement, and perceived school climate on students' self-awareness. The results of this study indicated that to foster students’ self-awareness, schools need to establish communication with parents, create a comfortable and effective school climate for teaching and learning processes, as well as facilitate the students to develop peer attachment through extracurricular activities. In addition, schools may also take actions to implement field-based learning and provide career counseling for students to broaden their insights of alternative self-development besides trading and farming.
Empowering critical thinking skills on different academic levels through discovery-based multiple representation learning
Authors: Chusni Muhammad Minan , Saputro Sulistyo , Suranto Suranto , Rahardjo Sentot Budi
Published: May 2022

Critical Thinking Skills (CTSs) are necessary for science mastery. To help the students develop their CTSs, discovery-based learning and student-centered activities may be beneficial. This study aims at investigating: (1) effects of discovery-based multiple representation learning (DMRL) model on CTSs; (2) effects of different academic achievement on CTSs; and (3) interaction between a learning model and types of different academic achievement on CTSs. The participants were 162 students, grade 7th from 3 public schools in Sleman, Indonesia. They were classified into 54 students with exceptional academic achievement, 48 students with average academic achievement, and 60 students with below-average intellectual ability. We used an essay test to collect data on CTSs utilizing a non-equivalent control group design with pretest and posttest. ANCOVA was used to examine the data (p = .05). The results of the study show that: (1) The DMRL had a high potential to improve the students’ CTSs; (2) The students with HA had the highest CTSs; (3) there is an interaction effect between the learning model and the different types of achievement on CTS. As a result, we conclude that the DMRL was effective in closing the CTSs discrepancies between students with high, moderate, and poor academic achievement.
Parental involvement of marginalized children’s education in Yogyakarta
Authors: Septiarti Serafin Wisni , Hanum Farida , Suadirman Siti Partini , Kusumawardani Erma
Published: May 2022

Families living in slum areas are exposed to dense population and low income, both of which are conditions that make it difficult to meet the educational needs of their children. This article describes the involvement of parents in educating their children at home and at school. The study was carried out using ethnographic methods with 33 marginal families as informants. Marginal families who have children of elementary school age in grades 5 and 6, especially those living on the outskirts or banks of the Winongo and Code rivers, 3 large rivers that seem to divide the city of Yogyakarta, were included in this study. Data were collected using interviews, observations and focus groups. The results of the study show parental involvement as a form of transformation of knowledge systems, values, attitudes and skills. This often occurs in a patterned manner, repeatedly using examples, sometimes coercion as educational praxis at home and school in specific social environment situations. The daily interaction between parents and children in parent-child conversations tends to be instructive and emphasizes compliance to fulfill children's educational needs.
Термодеструкция полиметилметакрилата и его композита с фуллереном C-=SUB=-60-=/SUB=- после ультрафиолетового облучения
Authors: Поздняков А.О.
Published: May 2022

The analysis of the ultraviolet induced transformation of the thermal decomposition spectra of the monomer of the submicrometer layers of polymethylmethacrylate and its composite with fullerene C60 for different fullerene concentrations and irradiation doses has been carried out. Formation of the new decomposition stages in the spectra has been interpreted by the binding between C60 and side ester groups of polymethylmethacrylate.
Многочастотные синхронные автоколебания в волоконных лазерах с оптомеханическими микроосцилляторами
Authors: Егоров Ф.А.
Published: May 2022

In erbium - ytterbium fiber lasers with mirrors based on sets of optomechanical microoscillators, modes of multi-frequency (up to five frequencies) synchronous self-oscillations are implemented; microoscillators are made in the form of silicon microbeams array with a quasi-equidistant spectrum of elastic vibration modes excited by laser radiation pressure. A significant dependence of self-oscillations on the spectral properties of optical resonator mirrors has been revealed, which is explained within the framework of the concepts of inhomogeneous broadening in the active fiber.
Влияние конденсации на размеры сверхзвуковых потоков
Authors: Дубровин К.А. , Зарвин А.Е. , Яскин А.С. , Каляда В.В.
Published: May 2022

The role of condensation on the shape and size of a supersonic argon stream flowing from a nozzle into a rarefied space is considered. It is shown that with the growth of cluster sizes, both the primary "traditional" supersonic jet and the external cluster flow formed when heavy clusters penetrate through the lateral compressed layers of the primary flow into the surrounding background gas increases. The type of correction factor in the well-known empirical formula proposed by Ashkenas and Sherman is found, taking into account which this formula can be used in conditions of clustered flows. The reasons for the impact of clusters on the gas dynamics of supersonic flow, conditions and limitations of such an effect are discussed.
Effects of Substance Use, Recovery, and Non–Drug-Related Online Community Participation on the Risk of a Use Episode During Remission From Opioid Use Disorder: Longitudinal Observational Study
Authors: Naserianhanzaei Elahe , Koschate-Reis Miriam
Published: May 2022

Background

Opioid addiction is currently one of the most pressing public health issues. Despite several treatment options for opioid addiction, the recurrence of use episodes during remission remains high. Research indicates that meaningful membership in various social groups underpins the successful transition from addiction to long-term remission. However, much of the current literature focuses on online peer-support groups for individuals in remission from substance use, sometimes also called recovery groups, a term we will use in line with the terminology used by the online community we studied. In contrast, online group memberships that promote substance use and groups that are unrelated to substance use and remission (non–drug-related groups) are rarely studied.

Objective

This study aims to understand whether engagement with a variety of Reddit subforums (subreddits) provides those in remission from opioid use disorder (OUD) with social capital, thereby reducing their risk of a use episode over several years. More specifically, it aims to examine the different effects of engagement with substance use, recovery, and non–drug-related subreddits.

Methods

A data set of 457 individuals in remission from OUD who posted their remission start date on Reddit was collected, of whom 219 (47.9%) indicated at least one use episode during the remission period. Using a Cox proportional hazards model, the effects of the number of non–drug-related, recovery, and substance use subreddits an individual had engaged with on the risk of a use episode were tested. Group engagement was assessed both in terms of the absolute number of subreddits and as a proportion of the total number of subreddits in which an individual had posted.

Results

Engagement with a larger number of non–drug-related online communities reduced the likelihood of a use episode irrespective of the number of posts and comments made in these forums. This was true for both the absolute number of non–drug-related communities (P<.001) and the proportion of communities with which a person engaged (P<.001). The findings were less conclusive for recovery support and substance use groups; although participating in more recovery support subreddits reduced the risk of a use episode (P<.001), being part of a higher proportion of recovery support groups relative to other subreddits increased the risk (P=.01). A higher proportion of substance use subreddits marginally increased the risk of a use episode (P=.06); however, the absolute number of substance use subreddits significantly reduced the risk of a use episode (P=.002).

Conclusions

Our work indicates that even minimal regular engagement with several non–drug-related online forums may provide those in remission from OUD with an opportunity to grow their social capital and reduce the risk of a use episode over several years.
Public Transport Use by People of Advanced Age
Authors: Beaton Jacqueline , Kerse Ngaire , Connolly Martin
Published: May 2022

Background: Both New Zealand M?ori and non-Maori males were most notable in the number who did not make use of public transport in the last twelve months. Method: Transport subsection of the LiLAC study provided the question area for analysis. Enquiry focused on whether older people had travelled on public transport in the last twelve months, how often they made use of the service and why they did not employ such facility. Methods of analysis included binomial logistic regression, Mann-Whitney U test, regression analysis and descriptive analysis.Results: Participants totaled 931 with 421 New Zealand Maori and 510 New Zealand Maori non-Maori.New Zealand Maori: The greater majority of New Zealand Maori signified that they did not use public transport. Of those that did, it was the females either on their own or with some difficulty. Of those that had engaged the service, (83-88 years), it was only once a week. Reasons given for not using public transport comprised primarily revolved around personal choice and knowledge of possible facilities. Other reasons given included continued use of a car, again not wanting to, no available facilities, family, health and the use of other methods of transportation.New Zealand non-Maori: A significant number of male New Zealand non-Maori indicated that had not used the service in the last twelve months. Although of those that did, a comparable number of both male and female non-Maori had similarly either completed the journey on their own or with difficulty. When asked how often they used the service, the majority indicated that they did not. Reasons being routes either not going where respondents wanted or needed to go; and females expressing concern about accessible bus stops or were inconvenient to use. Conclusion: National and/or local government have the opportunity to make improvements in route design, scheduling and diversity in type of bus being made available with the present and future growth of the older population. Also, in line with future developments such authorities could similarly work in conjunction with other providers such as service groups like Lions and Rotary; Retired Serviceman/women Association, Workingmen’s Clubs, Age Concern, Driving Miss Daisy, private organisations, taxi firms, or the provision of Uber sharing, in considering the type and style of public transport being made available to the public.
From contamination to banning: the legality of asbestos mining in comparison with fundamental rights
Authors: Oliveira Caio Coêlho de , Barros Cinthia da Silva
Published: May 2022

Beyond the theoretical formations concerning Environmental Constitutional Law, the issue that this work emphasizes is the importance of also analyzing the argumentative structure and the configuration of institutions, under the influence of the Fundamental Rights Theory. Thus, it is intended, based on the analysis of the case of the asbestos ban, to critically analyze the whole normative structure as well as the elements that motivated the Federal Supreme Court (STF) to dismiss the Direct Action for Constitutionality No. 4066. The discussion is then necessary to understand why there are limits on the use of this mineral, besides verifying that the absence of public policies contributes to the invisibility of asbestos-related problems in Brazil. Nowadays, the victims of asbestos do not have their illnesses recognized, and their rights are denied in various instances. It’s conclude that the fight to end the use of this fiber and to reduce the diseases caused by it is a political movement, as well as a legal one, since it is faced with the need to guarantee and enforce fundamental rights.
Mapa de paisajes físico-geográficos del Estado de Chiapas
Authors: Morales Iglesias Horacio , Priego Santander Ángel Guadalupe , Bollo Manent Manuel
Published: May 2022

"El mapa ofrece la distribución espacial de los paisajes físico-geográficos del estado de Chiapas a escala 1: 250 000. La leyenda incluye la definición de los geocomplejos en cinco niveles taxonómicos tipológicos: a) Clases b) Subclases c) Localidad d) Paraje Complejo e) Paraje Simple Los resultados indican que existen en el territorio 6 Clases, 19 Subclases, 118 Localidades, 181 Parajes Complejos y 450 Parajes Simples, con amplio predominio de los geocomplejos de génesis tectónico carsificados y tectónico intrusivo; aunque también están presentes geosistemas volcánicos, fluviales, lacustres y marino-terrígena, entre otros."
Paisajes físico-geográficos del Estado de Colima, México, a escala 1:250 000
Authors: Celis Ortega Manuel , Priego Santander Ángel Guadalupe , Ramírez Sánchez Luis Giovanni , Bollo Manent Manuel
Published: May 2022

El mapa ofrece la distribución espacial de los paisajes físico-geográficos del estado de Colima a escala 1: 250 000
Antifungal Activity of Honey Samples from Khyber Pakhtunkhwa (Pakistan) as affected by Botanical Origin
Authors: Rahman Khaliq Ur , Ullah Imdad , Ullah Kamran , Husain Arshad , Ullah Shafqat , Rauf Abdur , Gul Zainab , Rahman Halim Ur , Ramadan Mohamed Fawzy
Published: May 2022

The present study evaluated the antifungal activity of honey samples collected from different locations at Khyber Pakhtunkhwa (KPK, Pakistan). Disc diffusion method was used to test the antifungal potential of twenty-one (branded, unbranded, and natural comb) honey samples from the different botanical origins at different concentrations (undiluted, 10%, 30%, and 50%, w/v) against Candida albicans and Rhodotorula species. Branded, unbranded, and natural comb honey samples generate different inhibition zones (4-13 mm, 5-15 mm, and 8-17 mm) against Rhodotorula species. Candida albicans showed resistance for all tested honey samples. Minimum inhibitory concentration (MIC) against Candida albicans and Rhodotorula species were 53.33%-88.12% and 1.76%-90.22% for branded, 61.3% – 93.8% and 9.90% – 95.5% for unbranded, and 67.1%-96.8% and 6.39%-98.8% for natural comb honey. In conclusion, natural comb honey from Khyber Pakhtunkhwa may have antifungal therapeutic potential and could be a useful source for generating functional food.
The Association of the mazEF Toxin-antitoxin System and Vancomycin Resistance in Clinical Isolates of Vancomycin Resistant Enterococcus faecalis
Authors: Sultan Amira M. , Gouda Nawal S.
Published: May 2022

Vancomycin resistant enterococci are challenging bacteria as they are difficult to be eradicated. Toxin-antitoxin (TA) systems are genetic elements located in most prokaryotic genomes. The mazEF TA system is harbored by a plasmid among Enterococcus faecalis (E. faecalis). To explore the relation between the existence of mazEF TA system and vancomycin resistance among clinical isolates of E. faecalis. Samples were collected from patients showing clinical picture of infection. Isolates of E. faecalis were identified by standard microbiological methods and their antimicrobial susceptibility patterns were detected by disk diffusion method. In addition, the E-test was used to confirm vancomycin resistant isolates. All the E. faecalis isolates were screened for the mazEF TA system by PCR. A total of 180 E. faecalis strains were identified with a vancomycin resistance rate of 30.6%. Vancomycin resistance was significantly associated with prolonged hospital stay (P= 0.04) and ICU setting (P= 0.001). The mazEF TA system was detected among 100% of vancomycin resistant isolates, while only 33.6% of the vancomycin sensitive isolates carried the system with a significant difference (P= 0.002). In addition, there was a significant association between the mazEF TA system-positive strains and the ICU setting (P= 0.02). A significant association was found between vancomycin resistance and the presence of the mazEF TA system among E. faecalis isolates. This association supports the current efforts to utilize the mazEF TA system as a possible target for novel antibacterial agents; however, further studies on a wider scale are necessary.
An Optimization Framework of Adaptive Computing-plus-Communication for Multimedia Processing in Cloud: A Review
Authors: Dabhade Kiran Bhimrao , Mankar C. M.
Published: May 2022

Abstract: Clear trend within the evolution of network-based services is that the ever-increasing amount of multimedia system data concerned. This trend towards big-data multimedia system process finds its natural placement at the side of the adoption of the cloud computing paradigm, that looks the most effective solution to the strain of a extremely fluctuating work that characterizes this sort of services. However, as cloud data centers become a lot of and a lot of powerful, energy consumption becomes a significant challenge each for environmental concerns and for economic reasons. An effective approach to improve energy efficiency in cloud data centers is to rely on traffic engineering techniques to dynamically adapt the number of active servers to the current workload. Towards this aim, we propose a joint computing-plus-communication improvement framework exploiting virtualization technologies. Our proposal specifically addresses the everyday situation of data processing processing with computationally intensive tasks and exchange of a giant volume of data. The proposed framework not only ensures users the Quality of Service, but also achieves maximum energy saving and attains green cloud computing goals in a fully distributed fashion by utilizing the DVFS-based CPU frequencies Keywords: Energy efficiency, Multimedia data processing, Cloud resource management, Load balancing, Dynamic voltage and frequency scaling (DVFS), Traffic engineering
EFEITO DA REVISÃO DA NORMA DE ARRENDAMENTOS NO CONSERVADORISMO CONTÁBIL DAS COMPANHIAS ABERTAS DE BENS INDUSTRIAIS
Authors: Moura Paulo Junio Pereira de , Ferreira Marília Paranaíba , Carmo Carlos Henrique Silva do , Machado Lúcio de Souza
Published: May 2022

Objetivo: Este estudo objetiva verificar o efeito da revisão da norma de arrendamentos no conservadorismo contábil das companhias abertas de bens industriais listadas na B3.
Método: As companhias foram analisadas por meio de regressões múltiplas fundamentadas no modelo de Ball e Shivakumar (2005).
Principais resultados: Os resultados apontaram um comportamento mais conservador das companhias do setor de bens industriais após a adoção do Pronunciamento Técnico CPC 06 (R2) – Arrendamentos, o que representa um ganho na qualidade informacional dos relatórios reportados, visto que as obrigações de arrendamento subavaliadas passaram a ser incorporadas no balanço patrimonial.
Contribuições: Como contribuição, as evidências empíricas podem gerar dados importantes que permitem reflexões quanto a eficácia das alterações dos pronunciamentos técnicos, além de auxiliar profissionais e normatizadores nos debates sobre as futuras revisões da norma e colaborar com o avanço dessa discussão no ambiente acadêmico.
Relevância: O CPC 06 (R2), vigente no Brasil a partir de 1º de janeiro de 2019 e elaborado em conformidade com a International Financial Reporting Standards 16 – Leases, trouxe mudanças significativas acerca do reconhecimento, mensuração e evidenciação contábil dos arrendamentos, pois os arrendamentos, até então classificados em duas modalidades (financeiro e operacional) segundo o CPC 06 (R1) – Operações de Arrendamento Mercantil, passaram a receber o mesmo tratamento contábil para os arrendatários e, portanto, extinguiu-se a diferença entre arrendamento financeiro e operacional. Nesse sentido, a relevância deste estudo está em verificar se a revisão da norma de arrendamentos contribui para melhorar a qualidade da informação contábil.
Historia de la criminalidad: una reflexión sobre la reciente producción historiográfica en Colombia
Authors: Ariza Arias Kelly Johanna
Published: May 2022

Este ensayo bibliográfico presenta y hace una relación entre cuatro textos historiográficos de producción reciente cuyo tema en común es la criminalidad en el territorio de la Nueva Granada y posteriormente Colombia. El periodo histórico trabajado en los libros va desde el siglo XVII hasta el XX, pero se puede identificar un énfasis en los siglos XVIII y XIX. Aunque el tema del crimen y el delito es transversal en todos los textos, el ensayo aborda desde diferentes perspectivas dicha temática. Las reflexiones que se desarrollan sobre los libros giran en torno a la transgresión, la mujer, la raza y la posición social.
Antibody responses of COVID-19 patients according to symptoms and the presence of pneumonia
Authors: KORKUSUZ Ramazan , KARANDERE Faruk
Published: May 2022

Introduction: The aim of the study was to examine the 30-day total SARS-CoV-2 antibody positivity in patients across a clinical spectrum ranging from asymptomatic to pneumonia.Methods: This prospective cohort study consisted of 51 consecutive patients who were RT-PCR positive and diagnosed COVID-19 pneumonia (Group 1) and 58 consecutive patients who were also RT-PCR positive but were asymptomatic or had mild symptoms (Group 2). On the 30th day from the date of symptom onset, the patients were called for examination and blood samples were taken for the detection of SARS-CoV-2 antibodies.Results: Patients with pneumonia, fever, muscle pain, and loss of taste and smell had significantly higher rates of antibody positivity (p= 0.001, 0.003, 0.030, and 0.018, respectively). Antibody positivity was found to be significantly higher in patients with at least one symptom on admission compared to asymptomatic patients (p = 0.001). While the antibody positivity rate was 96.1% in Group 1 (patients with pneumonia), it was 50% in Group 2 (patients without pneumonia), and 77.7% in patients with at least one symptom on admission compared to 33.3% in asymptomatic patients (p=0.001).Conclusions: Patients with COVID-19 pneumonia have significantly higher disease-specific total antibody positivity rates than patients without pneumonia. Considering the 50% antibody positivity in patients who had COVID-19 infection who were asymptomatic or had symptoms other than pneumonia, the issue of COVID-19 re-infection and immunity is much more important than it appears.
Non-consanguineous pediatric myelofibrosis due to MPIG6B mutations in a patient of European ancestry
Authors: Yenwongfai Leonard , Arora Ranjana , Smith Alexander , Kalfa Theodosia , Husami Ammar , Radulescu Vlad , Myers Kasiani , Lorsbach Robert
Published: May 2022

Myelofibrosis (MF) in the pediatric setting is uncommon and appears to
be pathogenically heterogeneous. MF due to intrinsic bone marrow
abnormality (IMF) is distinct from adult-type Primary myelofibrosis
(PMF) as they can lack the common genetic markers of clonality. To date,
all but two reported patients with pediatric MF and mutated MPIG6B have
been Arabic, and all reported cases have had a family history of
consanguinity. Here we report the first North American patient of
European ancestry with pediatric MF in whom novel compound heterozygous
mutations of MPIG6B were identified.
THE EVALUATION OF MEDULLA SPINALIS PERFUSION AT MODERATE HYPOTHERMIA WITH PATIENTS WHO UNDERGO ANTEGRADE SELECTIVE CEREBRAL PERFUSION IN ASCENDING AND ARCUS AORTIC SURGERY
Authors: Ozbek Mehmet Hamdi , Civelek İsa , Akkaya Boğaçhan , Kiris Erman , SUNGUR Elif COŞKUN , BENLİ Emre Demir , Unal Ertekin , Aksoyek Aysen , Saritas Ahmet
Published: May 2022

Aim: Antegrade Selective Cerebral Perfusion (ASCP) with lower
body circulatory arrest (LBCA) used in aortic arch surgery can lead to
postoperative ischemic organ dysfunctions if it lasts long enough. We
aimed to evaluate methods that can provide early detection of spinal
cord ischemia during aortic arch surgery. Methods: Thirty
consecutive patients were prospectively enrolled and Near infrared
spectrometry (NIRS) data obtained from the 5 and 10
thoracic vertebral region, S100β protein, lactate
blood levels during various operative phases and postoperative
neurological outcomes were evaluated. Results: A total of 30
patients underwent elective hemi arch (73.29%) or total arch (23.31%)
replacement and with a mean ASCP period of 25.1 ± 19.0 (limits 10-90)
minutes. In-hospital mortality was 6.66% (two patients). Paraparesis
developed in one patient (3,33%). Thoracic T5 and T10 NIRS values were
lowest during the ASCP period (p<0.001) with a good
correlation between them (r=0.853, p<0.001). However, a
significant difference between the T5 and T10 levels was observed during
the same period (55.40 vs 51.07 respectively, p=0.001). A moderately
negative correlation between the lactate levels in descending aorta and
NIRS values at the T10 level was found during ASCP (r =-0.514, p =
0.004). Conclusion: Thoracic 5 and 10
level NIRS monitoring for spinal cord oxygenation
were significantly lower during ASCP period compared to the other
periods of aortic arch surgery with T10 values being lower than T5
values during the same period indicating a more significant flow
disturbance at this level. Measuring lactate levels with thoracic NIRS
monitoring seems promising for future studies with larger volumes and
longer ASCP periods.
10-LB: Psychosocial Impact of Severe Hypoglycemia and Perceptions of Nasal Glucagon in Young Adults with Type 1 Diabetes
Authors: KELLY CAITLIN S. , NGUYEN HUYEN , LUO WEIXIU , CHAPMAN KATHERINE S.M. , POON JIAT LING , BAKER LEVENIA A. , WOLF WENDY , PEREZ-NIEVES MAGALY , MITCHELL BETH
Published: May 2022

Experiences of a severe hypoglycemic event (SHE) , although infrequent occurrences, may interfere with engaging in social activities and increase distress. Previous work in parents suggests having nasal glucagon (NG) - a ready-to-use rescue agent for SHE - alleviates some of these psychosocial concerns. To examine whether young adults also perceived psychosocial benefits from NG, we recruited individuals aged 18-26 with T1D for an online survey. Participants rated the perceived impact of possible SHEs on fully engaging in social activities and distress (‘strongly disagree’ to ‘strongly agree’) and perceived changes since starting NG (‘worsened a great deal’ to ‘improved a great deal’) . Participants then answered questions about preparedness and protection using a validated measure to compare perceptions of NG to a glucagon kit requiring reconstitution. The final sample included 364 young adults (Meanage = 21.6 years; 73.6% female; MeanHbA1c = 7.1%) . Roughly one third of participants (35.4%) agreed/strongly agreed that possible SHEs limited their engagement in social activities. Most participants (63.7%) agreed/strongly agreed that treating a SHE was distressing. Since having NG, 30.9% of participants reported their freedom to engage in social activities improved/greatly improved and 67.4% reported no change. Of those who reported some amount of distress about SHEs (n = 326) , 49.7% reported their distress improved/greatly improved (i.e., reduced) and 48.8% of participants reported no change. Participants reported greater positive perceptions of Preparedness/Protection with NG (Median = 5.9, IQR = 5.1-6.3) compared to the glucagon kit requiring reconstitution (Median = 4, IQR = 3-4.9) as analyzed with a Wilcoxon signed rank test (p < .001) . Our results suggest that NG may provide meaningful psychosocial benefits for young adults, which could be especially important as they navigate this transitional age for diabetes management.

Disclosure

C. S. Kelly: None. H. Nguyen: None. W. Luo: Other Relationship; Lilly, Sanofi. K. S. M. Chapman: None. J. Poon: Employee; Eli Lilly and Company. Stock/Shareholder; Eli Lilly and Company. L. A. Baker: None. W. Wolf: None. M. Perez-Nieves: Employee; Eli Lilly and Company. Stock/Shareholder; Eli Lilly and Company. B. Mitchell: Employee; Eli Lilly and Company. Stock/Shareholder; Eli Lilly and Company.

Funding

Eli Lilly and Company
1005-P: A Multimodel Model Predictive Controller Can Improve Glucose Control in Children with Type 1 Diabetes (T1D)
Authors: PALISAITIS EMILIE , JONES RICHARD , KATZ MICHELLE , WOLPERT HOWARD , FATHI ANAS EL , HAIDAR AHMAD , VON OETTINGEN JULIA E. , LEGAULT LAURENT
Published: May 2022

Background: Many youth with type 1 diabetes do not achieve glycemic targets motivating the development of new therapeutic options for this population. We tested an automated insulin delivery system (AID) that uses a multi-model model predictive controller in children with T1D.

Methods: We conducted a 40-hour free-living clinical trial to assess our automated insulin delivery algorithm in children aged 7-13 years old with T1D (mean age 10.5±2.0 years, HbA1c 7.9±0.7%, duration of T1D 5.2±2.8 years) . Participants underwent a 7-day run-in period on sensor-augmented pump therapy followed by two 40-hour intervention periods composed of four hours of open-loop and 36 hours of AID use. Controller settings were identical in both intervention periods. Mean time-in-ranges were compared by paired T-test.

Results: Time in target (3.9-10mmol/L) and time in hyperglycemia (>10mmol/L) improved during intervention periods vs. run-in (52.2% vs. 65.6%; p<0.and 45.1% vs. 30.8%; p=0.respectively) while time in hypoglycemia (<3.9mmol/L) during intervention periods was unchanged from the run-in (1.8 vs. 2.0%, p=0.96) .

Conclusion: Early results suggest our advanced model predictive controller improves glucose control in a 7-13-year-old population with T1D. Larger and longer trials are warranted.

Disclosure

E.Palisaitis: Other Relationship; Eli Lilly and Company. R.Jones: Employee; Eli Lilly and Company, Stock/Shareholder; Eli Lilly and Company. M.Katz: Employee; Eli Lilly and Company, Stock/Shareholder; Eli Lilly and Company. H.Wolpert: Employee; Lilly Diabetes. A.El fathi: Other Relationship; Eli Lilly and Company. A.Haidar: Consultant; Eli Lilly and Company, Research Support; ADOCIA, Dexcom, Inc., Eli Lilly and Company, Tandem Diabetes Care, Inc. J.E.Von oettingen: None. L.Legault: Advisory Panel; Abbott Diabetes, Insulet Corporation, Novo Nordisk A/S, Other Relationship; Eli Lilly and Company, Research Support; AstraZeneca, Merck & Co., Inc.

Funding

Eli Lilly
1011-P: School-Day Routines Positively Impact Time in Range for Children with Type 1 Diabetes
Authors: MARCH CHRISTINE , LUTZ JAMES K. , JEONG KWONHO , SIMINERIO LINDA M. , ROTHENBERGER SCOTT D. , MILLER ELIZABETH , LIBMAN INGRID
Published: May 2022

The impact of school day routines on glycemic control in children is unclear. We compared continuous glucose monitor (CGM) metrics for youth with type 1 diabetes during weekday school hours (8AM-3PM) between two 4-week periods before and during the COVID-pandemic, when children had transitioned to virtual school. Youth with >70% CGM wear (n=209) were included; 46% male, mean±SD age 10.6±1.5 years, hemoglobin A1c 7.5±0.8%, 64% on insulin pumps. Time in range (TIR, 80-180 mg/dL) was similar during the pandemic (51.6±24.1%) compared to pre-pandemic (50.8±23.3%) . Using random coefficient multilevel linear mixed models, younger age (p=0.025) and pump use (p=0.043) predicted TIR, but not race (p=0.76) , diabetes duration (p=0.07) , body mass index (p=0.54) , or insurance status (p=0.45) . TIR pre- vs. during the pandemic varied significantly by time of day (p<0.001) . With in-person school pre-pandemic, TIR increased over school hours; with virtual school during the pandemic, TIR decreased in the morning and then remained steady (Figure) . Time above range (TAR, >180 mg/dL) had the opposite pattern. These findings suggest that in-person school can contribute to better TIR and lower TAR. Possible explanations include classroom and physical activity routines, plus school nurse support. During virtual school, continued routines are important and interventions to optimize diabetes care in school may benefit glycemic control.

Disclosure

C.March: None. J.K.Lutz: None. K.Jeong: None. L.M.Siminerio: Advisory Panel; Abbott, Bayer AG, Research Support; Becton, Dickinson and Company, Sanofi. S.D.Rothenberger: None. E.Miller: Other Relationship; Wolters Kluwer Health. I.Libman: Consultant; Novo Nordisk.

Funding

ISPAD-JDRF Fellowship Award UPMC Children's Hospital of Pittsburgh Cochrane Weber Endowment