bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal analysis of bovine mammary gland development
Authors: Vang Alysia L. , Bresolin Tiago , Frizzarini Waneska S. , Menezes Guilherme L. , Cunha Thiago , Rosa Guilherme J. M. , Hernandez Laura L. , Dorea Joao R. R.
Published: May 2023

Many studies on bovine mammary glands focus on one stage of development. Often missing in those studies are repeated measures of development from the same animals. As milk production is directly affected by amount of parenchymal tissue within the udder, understanding mammary gland growth along with visualization of its structures during development is essential. Therefore, analysis of ultrasound and histology data from the same animals would result in better understanding of mammary development over time. Thus, this research aimed to describe mammary gland development using non-invasive and invasive tools to delineate growth rate of glandular tissue responsible for potential future milk production. Mammary gland ultrasound images, biopsy samples, and blood samples were collected from 36 heifer dairy calves beginning at 10 weeks of age, and evaluated at 26, 39, and 52 weeks. Parenchyma was quantified at 10 weeks of age using ultrasound imaging and histological evaluation, and average echogenicity was utilized to quantify parenchyma at later stages of development. A significant negative correlation was detected between average echogenicity of parenchyma at 10 weeks and total adipose as a percent of histological whole tissue at 52 weeks. Additionally, a negative correlation between average daily gain at 10 and 26 weeks and maximum echogenicity at 52 weeks was present. These results suggest average daily gain and mammary gland development prior to 39 weeks of age is associated with development of the mammary gland after 39 weeks. These findings could be predictors of future milk production, however this must be further explored.
Formulation and process determined fouling prediction for the continuous emulsion co polymerisation of vinyl acetate
Authors: Rust Sören , Pauer Werner
Published: May 2023

Fouling is challenging for the industrial implementation of continuous emulsion polymerisations. A requirement for the development of successful anti-fouling concepts is an in-depth understanding of the processes involved in fouling and the knowledge of the main influencing factors. In this work, an experiment-based strategy was developed for the quantification of fouling trends and in order to calculate the expected fouling intensities during the continuous emulsion polymerisation of vinyl acetate copolymers. These, then, can be correlated with the direct process parameters temperature, initiator and emulsifier content and comonomer ratio. The expected fouling tendency for formulations could be determined in the investigated range with an accuracy of ± 15% referred to experimental validations.
High thermal conductivity of green nanofluid containing Ag nanoparticles prepared by using solution plasma process with Paramignya trimera extract
Authors: Hao Nguyen Van , Tung Do Hoang , Thao Truong Thi , Hoa Vu Xuan , Thoan Nguyen Hoang , Tan Pham The , Minh Phan Ngoc , Fal Jacek , Żyła Gaweł , Trinh Pham Van
Published: May 2023

Herein, we present for the first time a quick, easy, effective, and green method for preparing green nanofluids containing silver nanoparticles. The solution plasma method with a high-voltage DC power source and extracts from the Paramignya trimera was employed to prepare silver nanoparticles. The obtained results showed that silver nanoparticles were spherical, with a small average size of − 8 nm and fairly uniformly dispersed in solution. Surface plasmon resonance spectra show a strong peak at 410 nm for the prepared samples. The Fourier transform infrared spectra revealed the presence of possible functional groups on the surface of silver nanoparticles. Furthermore, the formation mechanism of silver nanoparticles is also proposed. The effect of the preparation times on the thermal conductivity of nanofluid was also investigated. As a result, the nanofluids prepared with longer preparation times had higher thermal conductivity and the highest improvement of 18.3% was obtained for the nanofluid using 4 min preparation compared to the base fluid. The obtained results indicate promise for a simple, fast, and environmentally friendly method for producing nanofluids containing silver nanoparticles with high thermal conductivity for potential applications.
Practices, beliefs, and attitudes of clinicians in prescribing direct oral anticoagulants for obese adults with atrial fibrillation: a qualitative study
Authors: Shaikh Fahad , Wynne Rochelle , Castelino Ronald L. , Inglis Sally C. , Davidson Patricia M. , Ferguson Caleb
Published: May 2023

Background

Atrial fibrillation (AF) and obesity affect over 60 and 650 million people, respectively.

Aim

This study aimed to explore clinician practices, beliefs, and attitudes towards the use of direct oral anticoagulants (DOACs) in obese adults (BMI ≥ 30 kg/m2) with AF.

Method

Semi-structured interviews via video conference were conducted with multidisciplinary clinicians from across Australia, with expertise in DOAC use in adults with AF. Clinicians were invited to participate using purposive and snowball sampling techniques. Data were analysed in NVIVO using thematic analysis.

Results

Fifteen clinicians including cardiologists (n = 5), hospital and academic pharmacists (n = 5), general practitioners (n = 2), a haematologist, a neurologist and a clinical pharmacologist participated. Interviews were on average 31 ± 9 min. Key themes identified were: Health system factors in decision-making Disparities between rural and metropolitan geographic areas, availability of health services, and time limitations for in-patient decision-making, were described; Condition-related factors in decision-making Clinicians questioned the significance of obesity as part of decision-making due to the practical limitations of dose modification, and the rarity of the extremely obese cohort; Decision-making in the context of uncertainty Clinicians reported limited availability, reliability and awareness of primary evidence including limited guidance from clinical guidelines for DOAC use in obesity.

Conclusion

This study highlights the complexity of decision-making for clinicians, due to the limited availability, reliability and awareness of evidence, the intrinsic complexity of the obese cohort and limited guidance from clinical guidelines. This highlights the urgent need for contemporary research to improve the quality of evidence to guide informed shared decision-making.
Lonely Places and Lonely People
Authors: Ratcliffe Matthew
Published: May 2023

Feeling lonely, being a lonely person, and living through lonely times can all be construed in terms of the emotional experiences of individuals. However, we also speak of lonely places. Sometimes, a place strikes us as lonely even when we do not feel lonely ourselves. On other occasions, finding a place lonely also involves feeling lonely, isolated, and lost. In this paper, I reflect on the phenomenological structure of loneliness by addressing what it is to experience a place as lonely. I suggest that approaching loneliness in this way can help us to see how it involves not merely the lack or absence of something but, more specifically, the sense ofbeing unable toaccess social and personal possibilities that may still appear accessible to others.
Comparative analysis of bone outcomes between quantitative ultrasound and dual-energy x-ray absorptiometry from the UK Biobank cohort
Authors: Swinton Paul A , Elliott-Sale Kirsty J , Sale Craig
Published: May 2023

Summary

This large cohort study investigated reliability and validity of heel ultrasound to estimate bone mineral density in adults. Reliability calculated between left and right heels was relatively poor and so was criterion validity assessed relative to dual-energy X-ray absorptiometry. Heel ultrasound should be used cautiously when estimating bone mineral density.

Introduction

Calcaneal quantitative ultrasound (QUS) may be used as a safe, low cost, and portable means to estimate bone mineral density (BMD) in large cohorts. The purpose of this study was to quantify the reliability and validity of QUS in comparison to dual-energy X-ray absorptiometry (DXA), which is the reference method for BMD measurement and diagnoses of osteopenia and osteoporosis.

Methods

Bone outcomes measured on the large UK Biobank cohort were used. The reliability of QUS estimated BMD was quantified by comparing values obtained from the left and right heel measured in the same session. Criterion validity was assessed through agreement between QUS and DXA, quantifying correlations, and sensitivity and specificity of osteopenia and osteoporosis diagnoses.

Results

Reliability calculations were made using data from over 216,000 participants demonstrating similar QUS BMD values between left and right heels in the absolute scale (Sd of difference for men: 0.12 and 0.07 g·cm−2). However, when expressed in relative scales, including concordance of quartiles, reliability was poor. Agreement between QUS and DXA was quantified using data from 5042 participants. Low to modest correlations (r = 0.29 to 0.44) were obtained between multiple QUS variables and DXA BMD, with sensitivity identified as very poor (0.05 to 0.23) for osteoporosis, and poor (0.37 to 0.62) for osteopenia diagnoses.

Conclusions

The findings of this large comparative analysis identify that whilst calcaneal QUS has the potential to produce reliable absolute BMD measurements and demonstrate modest associations with DXA BMD measures, use of that information to make relative statements about participants in the context of the larger population or to appropriately diagnose osteopenia or osteoporosis may be severely limited.
Changes in Fat-Free Mass, Protein Intake and Habitual Physical Activity Following Roux-en-Y Gastric Bypass Surgery: A Prospective Study
Authors: Nuijten Malou A. H. , Eijsvogels Thijs M. H. , Sanders Boy , Vriese Laura M. , Monpellier Valerie M. , Hazebroek Eric J. , Janssen Ignace M. C. , Hopman Maria T. E.
Published: May 2023

Purpose

Large inter-individual variations in post-bariatric fat-free mass loss (FFML) are observed, which might relate to differences in protein intake and physical activity across patients. We performed repetitive assessments of protein intake and physical activity before and after banded Roux-en-Y gastric bypass surgery, and examined its relations to FFML during 6 months of follow-up.

Materials and Methods

FFML (bio-impedance analyses), protein intake (24-h dietary recalls) and moderate-to-vigorous physical activity (MVPA; activPAL) were assessed in 28 patients (4 males, age 42 ± 12 years) before surgery and at 1-, 3- and 6-months post-surgery. Changes in protein intake and MVPA were evaluated with mixed model analysis, whereas associations with FFML were assessed by univariate regression analysis.

Results

Six-month FFML was -7.3 ± 3.6 kg. Protein intake decreased from 80 ± 29 g/day (pre-surgery) to 45 ± 26 g/day (1 month post-surgery (P < 0.001)) and did not improve thereafter (51 ± 21 g/day;P > 0.05). Seven participants (25%) consumed ≥ 60 g protein/day at 6 months post-surgery. Participants performed 7394 ± 2420 steps/day in 54 ± 20 min/day of MVPA, which did not change from pre- to post-surgery (P > 0.05). A higher step count (B = -0.002; 95%CI = [-0.004 – 0.000];P = 0.048) and higher level of MVPA (B = -0.29; 95%CI = [-0.54 – -0.03];P = 0.018) were related to a lower FFML.

Conclusion

A lower post-surgery FFML was attributable to higher MVPA levels but not protein intake. This may be due to the low total protein intake and the observation that only a minority of patients achieved a protein intake ≥ 60 g/day. Future studies should focus on interventions to increase post-bariatric protein intake and MVPA levels.

Graphical Abstract
Targeting Glutamine Metabolism as an Attractive Therapeutic Strategy for Acute Myeloid Leukemia
Authors: Xiao Yan , Hu Bingbing , Guo Yao , Zhang Dengyang , Zhao Yuming , Chen Yun , Li Na , Yu Liuting
Published: May 2023

Opinion statement

Relapse after chemotherapy and hematopoietic stem cell transplantation leads to adverse prognosis for acute myeloid leukemia (AML) patients. As a “conditionally essential amino acid,” glutamine contributes to the growth and proliferation of AML cells. Glutamine-target strategies as new treatment approaches have been widely explored in AML treatment to improve outcome. Glutamine-target strategies including depletion of systemic glutamine and application of glutamine uptake inhibitors, glutamine antagonists/analogues, and glutaminase inhibitors. Because glutamine metabolism involved in multiple pathways in cells and each pathway of glutamine metabolism has many regulatory factors, therefore, AML therapy targeting glutamine metabolism should focus on how to inhibit multiple metabolic pathways without affecting normal cells and host immune to achieve effective treatment for AML.
Reciprocal Interaction of Cancer Stem Cells of Cholangiocarcinoma with Macrophage
Authors: Wang Xin , Golino Jihye L. , Hawk Nga Voong , Xie Changqing
Published: May 2023

Cholangiocarcinoma is an aggressive type of liver cancer with few effective treatment options. Therefore, there is great need to better understand the biology of this malignancy to further development of novel treatment options. Cancer stem cells (CSCs) are thought to the underlying reason for cancer initiation, metastasis, and relapse. However, due to their elusive character and differences in identification among different types of cancer, it remains a challenge to study such cells. Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. Here, we employ a fluorescent reporter system to track and isolate stem-like cancer cells of cholangiocarcinoma cell lines. Following verification of a stem-like signature (upregulated expression of stemness markers, resistance to chemotherapy, increased spheroid formation, and tumorigenesis capabilities despite inoculation of a small number of cells), we analyzed the interaction of these cells with macrophages via direct and indirect coculture assays. We noted direct coculturing increased stemness among CSC populations and induced both M1 (CD80 and HLA-DR) and M2 (CD163) tumor associated macrophage polarization. These studies suggest that there is a bi-directional crosstalk between macrophages and CSCs that promotes stemness renewal and tumor associated macrophage polarization.

Graphical Abstract
Cultural Beliefs About Diabetes-Related Social Exclusion and Diabetes Distress Impact Self-Care Behaviors and HbA1c Among Patients with Type 2 Diabetes
Authors: Ly Albert L. , Flynn Patricia M. , Betancourt Hector M.
Published: May 2023

Background

Type 2 diabetes mellitus (T2DM) disproportionally impacts Latin Americans (Latinos) in the U.S. compared to non-Latino Whites, as reflected by an increased risk for disease complications and higher mortality rates. Guided by an Integrative Model of Culture, Psychological Processes, and Health Behavior, the purpose of the present study was to examine the role of cultural beliefs and diabetes distress as determinants of self-care behaviors and HbA1c among Latino patients with T2DM.

Methods

Participants included 109 Latino patients with T2DM recruited from a diabetes treatment center located in a region of Southern California with high diabetes mortality rates. Structural equation modeling was employed to examine the extent to which cultural beliefs about diabetes-related social exclusion and diabetes distress impact self-care behaviors and self-reported HbA1c.

Results

Consistent with the study hypotheses, cultural beliefs about diabetes-related social exclusion predicted diabetes distress, which in turn predicted poor diabetes self-care.

Conclusions

Findings suggest an important need for intervention efforts that address both cultural and psychological factors in order to improve diabetes self-care behaviors and associated disease outcomes among Latino patients with T2DM. Future research could benefit from investigating protective aspects of culture that could help counter the negative implications of cultural beliefs about social exclusion and diabetes distress associated with poor self-care.
Dumping military waste into Lake Superior: the historic legacies of secrecy, censorship, and uncertainty
Authors: Charrière Elodie , Langston Nancy
Published: May 2023

In recent years, the issue of military waste disposal in oceans and seas has gained significant attention; however, the impact of such waste in freshwater deposits has been understudied. The Laurentian Great Lakes of North America contain 20% of the world’s fresh surface water and are particularly vulnerable to environmental stressors such as climate change, invasive species, and toxic chemicals, making the examination of military waste management in these waters crucial. This interdisciplinary study aims to investigate the legacy of two military waste disposal sites in Lake Superior, referred to as Site A (containing barrels) and Site B (containing bullets). Both are located within the ceded territories of the Ojibwe. Despite being in close proximity, these sites have had vastly different outcomes in terms of public concern, state and federal regulatory actions, and tribal restoration efforts. Based on this observation, this study aims to answer the following questions: How did these differences develop? How did military secrecy and the loss of memory influence the management of underwater military waste at each site? How do uncertainties and rumors continue to influence citizen concern and agency management of military waste? We argue for the importance of investigating the environmental legacies of underwater military waste in order to protect inland freshwater resources worldwide.
The development of deep-ocean anoxia in a comprehensive ocean phosphorus model
Authors: Donohue J. G. , Florio B. J. , Fowler A. C.
Published: May 2023

We analyse a model of the phosphorus cycle in the ocean given by Slomp and Van Cappellen (Biogeosciences 4:155–171, 2007. https://doi.org/10.5194/bg-4-155-2007). This model contains four distinct oceanic boxes and includes relevant parts of the water, carbon and oxygen cycles. We show that the model can essentially be solved analytically, and its behaviour completely understood without recourse to numerical methods. In particular, we show that, in the model, the carbon and phosphorus concentrations in the different ocean reservoirs are all slaved to the concentration of soluble reactive phosphorus in the deep ocean, which relaxes to an equilibrium on a time scale of 180,000 y, and we show that the deep ocean is either oxic or anoxic, depending on a critical parameter which we can determine explicitly. Finally, we examine how the value of this critical parameter depends on the physical parameters contained in the model. The presented methodology is based on tools from applied mathematics and can be used to reduce the complexity of other large, biogeochemical models.
Getting the chronological age out of DNA: using insights of age-dependent DNA methylation for forensic DNA applications
Authors: Naue Jana
Published: May 2023

Background

DNA analysis for forensic investigations has a long tradition with important developments and optimizations since its first application. Traditionally, short tandem repeats analysis has been the most powerful method for the identification of individuals. However, in addition, epigenetic changes, i.e., DNA methylation, came into focus of forensic DNA research. Chronological age prediction is one promising application to allow for narrowing the pool of possible individuals who caused a trace, as well as to support the identification of unknown bodies and for age verification of living individuals.

Objective

This review aims to provide an overview of the current knowledge, possibilities, and (current) limitations about DNA methylation-based chronological age prediction with emphasis on forensic application.

Methods

The development, implementation and application of age prediction tools requires a deep understanding about the biological background, the analysis methods, the age-dependent DNA methylation markers, as well as the mathematical models for age prediction and their evaluation. Furthermore, additional influences can have an impact. Therefore, the literature was evaluated in respect to these diverse topics.

Conclusion

The numerous research efforts in recent years have led to a rapid change in our understanding of the application of DNA methylation for chronological age prediction, which is now on the way to implementation and validation. Knowledge of the various aspects leads to a better understanding and allows a more informed interpretation of DNAm quantification results, as well as the obtained results by the age prediction tools.
Optimal approximation of analog PID controllers of complex fractional-order
Authors: Mahata Shibendu , Herencsar Norbert , Maione Guido
Published: May 2023

Complex fractional-order (CFO) transfer functions, being more generalized versions of their real-order counterparts, lend greater flexibility to system modeling. Due to the absence of commercial complex-order fractance elements, the implementation of CFO models is challenging. To alleviate this issue, a constrained optimization approach that meets the targeted frequency responses is proposed for the rational approximation of CFO systems. The technique generates stable, minimum-phase, and real-valued coefficients based approximants, which are not always feasible for the curve-fitting approach reported in the literature. Stability and performance studies of the CFO proportional-integral-derivative (CFOPID) controllers for the Podlubny’s, the internal model control, and the El-Khazali’s forms are considered to demonstrate the feasibility of the proposed technique. Simulation results highlight that, for a practically reasonable order, all the designs achieve good agreement with the theoretical characteristics. Performance comparisons with the CFOPID controller approximants determined by the Oustaloup’s CFO differentiator based substitution method justify the proposed approach.
Monitoring of hive weight changes in various landscapes
Authors: Czekońska Krystyna , Łopuch Sylwia , Miścicki Stanisław , Bańkowski Janusz , Szabla Kazimierz
Published: May 2023

Bee development is determined by the quantity and quality of food resources available in the environment that can be used by bees only to a certain extent. Therefore, this study aimed to evaluate, by means of changes in hive weight, the amount of food collected by honey bees in various landscapes, in relation to meteorological conditions, landscape, and forest structure. The monitored colonies (n = 104) were placed on electronic beehive scales, which provided data about hive weight, temperature, and humidity over two beekeeping seasons. The landscape valuation within a 2 km radius from each beehive was prepared based on digital maps. The seasonal distribution of food resources collected by honey bees was determined based on hive weight changes analysed in 5-day-periods (i.e. pentads). The hive weight changes mainly depended on the observation period and the air temperature. The hive weight increased from April to the last 10 days of June and when the air temperature was over 24 °C. The proportions of agricultural lands and forests, as well as the air humidity, had a small effect on hive weight changes. Continuous monitoring of the weight of honey bee colonies on a large scale showed that honey bees collected food stores in their nests mainly in the spring. Then, they collected a small amount of food, probably due to limited access to food resources from the last 10 days of June until the end of the growing season.
A Local Cauchy Integral Formula for Slice-Regular Functions
Authors: Perotti Alessandro
Published: May 2023

We prove a local Cauchy-type integral formula for slice-regular functions. The formula is obtained as a corollary of a general integral representation formula where the integration is performed on the boundary of an open subset of the quaternionic space, with no requirement of axial symmetry. As a step towards the proof, we provide a decomposition of a slice-regular function as a combination of two axially monogenic functions.
Cumulative damage and bearing capacity attenuation law of anchorage structure interface under cyclic loading and unloading
Authors: Wang Peng , Guo Yuan , Cui Guangzhen , Zhang Nong , Xu Xingliang , Yu Chenghan , Li Aoran , Kan Jiaguang
Published: May 2023

The specimens of anchorage structures bonded by different anchoring materials are prepared to study the damage and reduced safety and reliability caused by the cyclic loading and unloading stress to the roadway anchorage structure. Using Fiber Bragg grating, acoustic emission monitoring and ANSYS, the anchorage structures’ bearing properties, interface failure characteristics, overall failure mode and internal influence mechanism are obtained under cyclic loading and unloading stress path. Results show that the cracks at the anchorage interface would develop and expand rapidly under this path, and the cumulative damage to anchorage structures is primarily caused by repeated residual deformation, periodic opening-expanding-closing of internal cracks, and impact vibration resulted from large-scale cyclic loading and unloading. Compared with the results under single pull-out stress, the ultimate loads of the anchorage structures bonded by H and S materials are reduced by 30.8% and 45.5%, respectively, and the radii of inner damage are increased by 1.64 and 1.67 times, respectively, showing a significant decrease in the bearing capacity of anchorage structures under cyclic loading and unloading. The anchorage structures bonded by these two materials have more prominent brittleness and weaker post-peak bearing capacity than those bonded by resin anchoring agent. Therefore, the balance between bonding strength and brittle-plastic extension characteristics shall be fully considered for the selection of anchoring materials. Five failure modes of anchorage structure are summarized: failure of the bolt-anchoring material interface, failure of the anchoring material-surrounding rock interface, fracture of the anchoring material, fracture of the bolt, and integral bulging of the anchorage structure. Besides, under the action of stress disturbance, the anchorage structure of bolt group can mobilize adjacent bolts to restrain the continuous damage and bearing capacity attenuation of the middle bolt, thus guaranteeing the overall safety and stability.
Global sensitivity analysis of 3D printed material with binder jet technology by using surrogate modeling and polynomial chaos expansion
Authors: Del Giudice Lorenzo , Marelli Stefano , Sudret Bruno , Vassiliou Michalis F.
Published: May 2023

The mechanical properties of 3D printed materials produced with additive manufacturing depend on the printing process, which is controlled by several tuning parameters. This paper focuses on Binder Jet technology and studies the influence of printing resolution, activator percentage, droplet mass, and printing speed on the compressive and flexural strength, as well as on the Young’s modulus of the bulk printed material. As the number of tests required using a one factor at a time approach is not time efficient, a Design of Experiments approach was applied and optimal points in the 4-dimensional parameter space were selected. Then Sobol’ sensitivity indices were calculated for each mechanical property through polynomial chaos expansion. We found that the mechanical properties are primarily controlled by the binder content of the bulk material, namely printing resolution and droplet mass. A smaller dependence on the activator percentage was also found. The printing speed does not affect the mechanical properties studied. In parallel, curing of the specimens at 80–115 °C for 30–120 min increases their strength.
The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles
Authors: Masdeu Carme , de los Santos Jesús M. , Palacios Francisco , Alonso Concepción
Published: May 2023

Nitrogen heterocycles are part of the structure of natural products and agents with important biological activity, such as antiviral, antibiotic, and antitumor drugs. For this reason, heterocyclic compounds are one of today’s most desirable synthetic targets and the Povarov reaction is a powerful synthetic tool for the construction of highly functionalized heterocyclic systems. This process involves an aromatic amine, a carbonyl compound, and an olefin or acetylene to give rise to the formation of a nitrogen-containing heterocycle. This review illustrates advances in the synthetic aspects of the intramolecular Povarov reaction for the construction of intricate nitrogen-containing polyheterocyclic compounds. This original review presents research done in this field, with references to important works by internationally relevant research groups on this current topic, covering the literature from 1992 to 2022. The intramolecular Povarov reactions are described here according to the key processes involved, using different combinations of aromatic or heteroaromatic amines, and aliphatic, aromatic, or heteroaromatic aldehydes. Some catalytic reactions promoted by transition metals are detailed, as well as the oxidative Povarov reaction and some asymmetric intramolecular Povarov processes.
The Miocene record of the Betic Cordillera uplift in Los Guájares valley (Granada province, S Spain)
Authors: Alberjón-Peñas Tomás , Braga Juan C. , Aguirre Julio , Flórez Paola
Published: May 2023

The Los Guájares valley is located about 35 km south of Granada in the Internal Zones of the Betic Cordillera. The Miocene deposits in this area consist of six sedimentary units separated by unconformities, which are exposed in small and laterally discontinuous outcrops overlying metamorphic rocks of the Alpujárride Complex. The lowest unit comprises upper Serravallian marls with planktonic foraminifera filling neptunian dykes and covering Triassic dolomitic marbles of the Alpujárride Complex. These marls reflect deep marine deposition on the Betic basement under a local extensional regime. Uplift of the region led to emergence and deposition of continental red alluvial-fan conglomerates and foothill breccias. The overlying unit, a shoreline conglomerate with small oyster banks, indicates relative sea-level rise. Shallow-marine conditions continued during the deposition of the following unit, early Tortonian in age, which consists of calcareous sandstones with hermatypic corals. Small patch reefs developed in the overlying unit composed of sandy limestones with corals (Porites, Tarbellastraea, Thegioastraea) and oysters, and sandy limestones with coralline algae in the most distal areas. The coral reefs in Los Guájares and some coral heads in Albuñuelas, a near locality, are the only record of early Tortonian coral buildups in the Mediterranean. The last marine unit comprises lower Tortonian conglomerates, sandstones and siltstones accumulated in the front of a small delta. Oyster banks and concentrations of Turritelines suggest high nutrient levels in the delta-front paleoenvironments. The Los Guájares valley area emerged afterwards, following the onset of a compressional geodynamic regime in the central Betic Cordillera and since the early Tortonian only small bodies of foothill and alluvial-fan deposits formed in a predominantly erosional context.
An app for apples: Citizen-led mapping of fire blight in Central Asia
Authors: Kurz Mirjam , Sultangaziev Ormon , Szalatnay David , Sodonbekov Ishenbai , Naizabayeva Dinara A. , Milikbekova Muqaddas , Akbarsho Solimshoh , Bobushova Saykal , Doolotkeldieva Tinatin , Rezzonico Fabio , Smits Theo H. M.
Published: May 2023

Fire blight, caused by the bacterial pathogen Erwinia amylovora, is a severe bacterial disease of apple and pear that can quickly destroy whole plants. In the last decade, it was also detected in Central Asia, where wild pomaceous fruit plants represent the dominant species in mid-altitude forests and constitute a critical foundation for the entire ecosystem. Efficiently informing farmers, forestry services and private persons about the instances and dangers of fire blight, the correct way to recognize the symptoms, and the methods of disease control is thus of paramount importance in a vast and fragmented natural landscape like the one characterizing countries like Kyrgyzstan, Kazakhstan and Tajikistan. For that purpose, we have developed an app for smartphones and mobile devices that can inform stakeholders about fire blight, simultaneously allowing a citizen science approach for mapping the spread of the disease in Central Asia. The app is available in the three national languages as well as in Russian, English, and German, and can easily be adapted to new countries, languages or even diseases.
Molecular Dynamics Simulation of Pore-Size Effects on Gas Adsorption Kinetics in Zeolites
Authors: Greathouse Jeffery A. , Paul Matthew J. , Xu Guangping , Powell Matthew D.
Published: May 2023

Strong gas-mineral interactions or slow adsorption kinetics require a molecular-level understanding of both adsorption and diffusion for these interactions to be properly described in transport models. In this combined molecular simulation and experimental study, noble gas adsorption and mobility is investigated in two naturally abundant zeolites whose pores are similar in size (clinoptilolite) and greater than (mordenite) the gas diameters. Simulated adsorption isotherms obtained from grand canonical Monte Carlo simulations indicate that both zeolites can accommodate even the largest gas (Rn). However, gas mobility in clinoptilolite is significantly hindered at pore-limiting window sites, as seen from molecular dynamics simulations in both bulk and slab zeolite models. Experimental gas adsorption isotherms for clinoptilolite confirm the presence of a kinetic barrier to Xe uptake, resulting in the unusual property of reverse Kr/Xe selectivity. Finally, a kinetic model is used to fit the simulated gas loading profiles, allowing a comparison of trends in gas diffusivity in the zeolite pores.
The Implementation Experience of COVID-19 Rapid Antigen Testing in a Large-Scale Construction Project in Victoria, Australia
Authors: Ludwick Teralynn , Creagh Nicola Stephanie , Goller Jane L. , Nightingale Claire Elizabeth , Ferdinand Angeline Samantha
Published: May 2023

The coronavirus (COVID-19) pandemic has caused major disruptions to industries and workplaces. Rapid Antigen Tests (RATs) for COVID-19, which allow individuals to self-administer tests and receive timely results without laboratory testing, provide the opportunity for surveillance testing of asymptomatic individuals in non-medical settings. However, the literature offers few lessons regarding how to create enabling conditions for effective and sustainable implementation in a workplace setting. Guided by the RE-AIM framework, we assessed factors associated with the adoption, implementation, and maintenance of mandatory RAT in a large-scale construction project in Victoria, Australia. We used a mixed methods approach involving site observation, worker surveys (n = 30), and interviews with 51 site workers and managers to understand the implementation experience. Factors which facilitated adoption included easy, non-invasive testing procedure; sense of workplace safety; and strong backing by management and acceptance by workers that RATs helped limit COVID-19-related lost days of work. Gaps in knowledge and adherence to testing protocols, logistical challenges (test kit supply, observation of test results), and low appetite for long-term, mandatory testing emerged as challenges for effective implementation and sustainability. As RAT becomes normalized in a range of workplace settings, strategies will be required to support the sustainability of implementation, including longer-term acceptability of surveillance testing and adherence to testing protocols.
The History of Parliament: The House of Commons
1640-1660 [Volume IV]
Authors: Roberts Stephen K.
Published: May 2023

Volume 4 of a
9-volume set providing the most comprehensive and complete study
ever compiled about the turbulent period of the English and
British Civil Wars and their aftermath.
False self-employment and bogus internships in Spain
Authors: Arrizabalo Montoro Xabier , del Rosal Crespo Mario , Murillo Arroyo Francisco Javier
Published: May 2023

This paper focuses on the state of precarious work in Spain: Are all those who work as self-employed persons and interns truly operating under those descriptions, or are many of them employees so precariously engaged that they have no labour contracts? If so, how has this come to pass? Why is it increasingly happening? This paper raises some answers based on the Marxist approach. We link employment instability to increased exploitation of the Spanish labour force. This trend is a reaction by capital to low rates of profit and the implementation of particular governmental economic policies implemented to meet the demands of the European Union. Due to the precariousness of work, prospects for achieving a stable and autonomous life for a large cohort of Spain’s working youth are seriously threatened.
Internal tide generation from non-uniform barotropic body forcing
Authors: Papoutsellis Christos E. , Mercier Matthieu J. , Grisouard Nicolas
Published: May 2023

We model linear, inviscid, internal tides generated by the interaction of a barotropic tide with one-dimensional topography. Starting from the body-forcing formulation of the hydrodynamic problem, we derive a coupled-mode system (CMS) using a local eigenfunction expansion of the stream function. For infinitesimal topography, we solve this CMS analytically, recovering the classical weak topography approximation (WTA) formula for the barotropic-to-baroclinic energy conversion rate. For arbitrary topographies, we solve this CMS numerically. The CMS enjoys faster convergence with respect to existing modal solutions and can be applied in the subcritical and supercritical regimes for both ridges and shelf profiles. We show that the non-uniform barotropic tide affects the baroclinic field locally over topographies with large slopes and we study the dependence of the radiated energy conversion rate on the criticality. We show that non-radiating or weakly radiating topographies are common in the subcritical regime. We also assess the region of validity of the WTA approximation for the commonly used Gaussian ridge and a compactly supported bump ridge studied here for the first time. Finally, we provide numerical evidence showing that in the strongly supercritical regime, the energy conversion rate for a ridge (respectively shelf) approaches the value obtained by the knife-edge (respectively step) topography.
Internally caused change as change by inner predisposition: Comparative evidence from Romance
Authors: BENTLEY DELIA
Published: May 2023

This article investigates the morphosyntax of verbs of internally caused scalar change and the main facets of their meaning. Availing ourselves of primary evidence from Italian, French, and Spanish corpora, we argue that the verbs under scrutiny divide into three subclasses whose common denominator is that they encode ‘change by inner predisposition’ or change that is possible because of inherent propensities of specific entities. We understand inner predisposition as a feature of the content of the verbs investigated, which has relevance to the choice of the undergoer, alongside the cause of two of the subclasses. Apart from this feature verbs of change by inner predisposition are indistinguishable from other verbs of change. We argue against an agentive or generalized causative analysis, and we advance a proposal for the lexical semantics of representatives of each of the three subclasses and for the alternations in which they participate.
Practicing ground rules in police interviews with child witnesses
Authors: Jol Guusje , Stommel Wyke
Published: May 2023

In police interviews with child witnesses, ground rules like ‘correct me when I say something wrong’ are established. Establishing these ground rules is required by guidelines, with the aim of enhancing the reliability of children's testimonies. In this article, we use conversation analysis to examine how ground rules are practiced in thirty-eight Dutch police interviews with child witnesses. We focus on the police officers’ use of test questions to practice such ground rules. We found that, often, these questions (at first) only consist of an if-clause. Questions with this format leave open whose turn it is and what the appropriate response should be. If-clause questions allow flexibility in the difficulty of the test question, and a subtle pursuit of a response from the child. Yet, they are also treated as problematic by children, shown by silences and hesitations. Surprisingly, the practicing of ground rules sometimes occasions affiliation. (Police interviews, children, testing, practicing, affiliation, conversation analysis, hypothetical questions)*
Affluence, congruence, and lobbying success in EU climate policy
Authors: De Bruycker Iskander , Colli Francesca
Published: May 2023

Strong climate policy is vital to tackling climate change, but even the best proposals can get watered down when lobbying occurs. This article analyses which interest groups lobby on EU climate policies and under which conditions these groups achieve their policy goals. We expect that both economic and political resources are important. Economic resources give groups the capacity to mobilise expertise, but an interest group’s success also depends on its congruence with public opinion, especially in a politicised area such as EU climate policy. To test our hypotheses, we focus on six EU climate policy issues for which we conducted expert surveys with lobbyists and a content analysis of 737 media statements in eight European news outlets, combined with Eurobarometer data. Our results show that interest groups with higher economic resources and with public opinion on their side are more likely to achieve their preferences on EU climate policy issues.
A Continuing Controversy: Has the Cometary Nucleus been Resolved?
Authors: Sekanina Zdenek
Published: May 2023

Barnard (1891) appears to have been the first to recognize the significance of systematic observations of comets at large distances from the sun. His successful tracing of two 1889 comets to heliocentric distances over 5 and even 6 a. u. caused him to notice that some of the short-period comets might be within the reach of the Lick Observatory’s 36-inch refractor throughout their entire orbits around the sun. Although it is clear nowadays that the short-period comets would be a good deal fainter at comparable distances than the two nearly parabolic comets referred to by Barnard, his original idea proved basically correct, except for the necessity of using photographic plates. Periodic Comet Encke was probably detected near aphelion during Barnard’s lifetime, in September 1913 (Barnard 1914a; Marsden and Sekanina 1974). Undisputed images of the comet just several days off aphelion were obtained in 1972 (Roemer 1972; McCrosky and Shao 1972).
The Nucleus: Panel Discussion
Authors: Huebner W. F.
Published: May 2023

Almost all information about the physics of the nucleus is based on deductions from observations of the coma and tails. It is well to keep in mind the hierarchy of events on which these deductions are based:

1. The material properties of the constituents of the nucleus and the detailed physical and chemical structure of the nucleus form the basis for the behavior of coma and tails.

2. Interaction of solar radiation with the surface of the nucleus determines the overall temporal development of the coma.

3. The subsequent interaction of solar radiation and solar wind with the coma determine the gross features of the tails.

4. Short term fluctuations primarily in the solar wind (and associated magnetic, field) cause disturbances of comparable duration observable mostly in the tail but also in the coma.
On the Origin of Comets
Authors: Mendis Asoka , Alfvén Hannes
Published: May 2023

The cosmogony of the planetary and satellite systems consists of understanding the physio-chemical processes leading to their formation and also trying to decide at what time and over what period their formation took place. The cosmogony of the comets require answers to not only these two questions but also as to where, in relation to the solar system, the observed and inferred distributions of comets were formed.
The Coma: Panel Discussion
Authors: Keller H. U.
Published: May 2023

I would just like to make a brief summary of some of the major points in my review two days ago. The most important results from the cometary UV observations are: (1) We know now that the gas production rates of a medium bright comet is on the order of 1030 molecules s-1 based on hydrogen Lα observations and interpretations. (2) The large amounts of OH indicate that water is an abundant molecule. I do not know of any other probable parent molecule of OH. The case for water as a parent molecule is strengthened by the parallel decrease of OH and H in comet Bennett and by arguments given by Delsemme. (3) Disregarding the observed amounts of OH and O, one would not necessarily conclude that the hydrogen is a dissociation product of water. The uncertainty is due to the deduced outflow velocities of about 8 km s-1. I feel this value for the velocity is pretty mysterious and not yet explained. We have yet to connect this velocity with the dissociation — or formation — producing the hydrogen atoms. The possibility that an appreciable amount of hydrogen does not stem from water cannot be excluded. (4) The UV observations of comet Kohoutek seem to indicate that water is not predominate over other molecules by two orders of magnitudes. The production of carbon atoms (and, therefore, of parent molecules containing carbon) seems to be nearly as great as that of water. The uncertainties of the numbers for the production rates are at least factors of two. I, personally, think it is too early to draw definite conclusions on the various abundance ratios. H, O, OH, and C may well be produced in the same order of magnitude. But a C deficiency by an order of magnitude (or even more) is not rules out either.
A Survey of Possible Missions to the Periodic Comets in the Interval 1974-2010
Authors: Bender D. F.
Published: May 2023

In order to survey the mission possibilities for the short period comets two catalogues are developed. In the first the physical and pertinent orbital characteristics are given for 65 short period comets. Since missions for short period comets are for the most part expected to utilize arrivals near perihelion at a time when the comet is comparatively active, the second catalogue is one containing the predicted perihelia for each of the 65 comets between 1974 and 2010. Included is enough geometry to indicate feasibility of Earth-based observation and sighting within 100 days of perihelion.