bluuebunny/crossref_metadata_2025 huggingface dataset:
SOCIAL INQUIRY METHOD AS A SOLUTION TO IMPROVE UNDERSTANDING OF THE CONCEPT OF SOCIAL PROBLEMS IN LEARNING SOCIAL SCIENCE FOR ELEMENTARY SCHOOL
Authors: Sundari Kori , Nurchoiriyah Nadilah
Published: June 2023

Ilmu Pengetahuan Sosial (IPS) adalah ilmu yang mempelajari tentang aktivitas kehidupan manusia dengan sejumlah aktivitas sosialnya. Dalam pembelajaran Ilmu Pengetahuan Sosial (IPS) untuk mengetahui dan memahami suatu istilah dan konsep diharapkan siswa memiliki kemampuan dasar untuk berpikir logis, rasa ingin tahu, memecahkan masalah, menganalisis, dan kemampuan pemahaman sebagai bekal siswa untuk melanjutkan pendidikan kejenjang yang lebih tinggi. Penelitian ini merupakan penelitian studi literatur yang menganalisis dan mengkaji hasil dari penelitian sebelumnya yang memiliki tema relevan. Jenis penelitian ini menggunakan pendekatan kualitatif dimana proses analisis data lebih menekankan pada penyimpulan perbandingan tinjauan dari beberapa jurnal ilmiah. Hasil penelitian ini menunjukan bahwa penerapan metode Inkuiri Sosial dapat meningkatkan Pemahaman Konsep Masalah Sosial siswa diyakini mampu menafsirkan, mencontohkan, mengklasifikasikan, merangkum, menyimpulkan, membandingkan, dan menjelaskan materi masalah sosial. Dengan penerapan Metode Inkuiri Sosial dapat menarik perhatian serta antusias siswa dalam pembelajaran sehingga siswa lebih aktif, serta tanggung jawab dalam kerja kelompok maupun individu, kemudian peserta didik menjadi percaya diri, berpikir kritis, dan dapat mengembangkan keterampilan kognitif peserta didik, sehingga pemahaman peserta didik lebih meningkat. Dengan demikian dapat disimpulkan bahwa Metode Pembelajaran Inkuiri Sosial dapat meningkatkan pemahaman konsep masalah sosil siswa pada Mata Pelajaran IPS.
PERANAN MODEL PEMBELAJARAN COOPERATIVE LEARNING TIPE TAKE AND GIVE DALAM MENINGKATKAN HASIL BELAJAR IPA SISWA SEKOLAH DASAR PADA MATERI SUMBER DAYA ALAM
Authors: Aningsih Aningsih , Yosa Mayda Intara
Published: June 2023

Ilmu Pengetahuan Alam adalah pembelajaran yang dilaksanakan di semua jenjang pendidikan, karena peserta didik dapat mempelajari diri sendiri dengan berhubungan pada alam sekitar lalu mengembangkan lebih jauh agar bisa diterapkan dalam kehidupan nyata. Hasil belajar IPA adalah kemampuan yang dimiliki siswa setelah ia menerima pengalaman belajar pada mata pelajaran IPA. Nilai hasil belajar adalah refleksi dari hasil pencapaian siswa pada segi kognitif (Pengetahuan), afektif (Sikap), maupun psikomotor (Keterampilan). Siswa akan memiliki kemampuan kognitif menjadi 7 tingkatan yaitu 1) mengingat (C1), proses pembelajaran dengan model Take and Give yang didukung oleh media kartu dapat melatih kecepatan siswa dalam berpikir cepat pada materi Sumber Daya Alam hayati dan non hayati. Contoh Sumber Daya Alam hayati yaitu tumbuhan dan hewan, kemudian contoh Sumber Daya Alam non hayati yaitu tambang, minyak bumi, tanah dan udara. 2) memahami (C2), menggunakan model Take and Give siswa akan mudah memahami contoh manfaat Sumber Daya Alam bagi manusia, 3) menerapkan (C3), siswa melakukan praktek langsung dalam proses pembelajaran pada Sumber Daya Alam. 4) menganalisis (C4), materi yang disajikan dalam bentuk kartu akan melatih siswa untuk menganalisa Sumber Daya Alam yang dapat diperbarui dan tidak dapat diperbarui. 5) mengevaluasi (C5), pada tahap untuk mengevaluasi keberhasilan siswa, guru dianjurkan memberikan pertanyaan yang tidak sesuai dengan kartu yang dipegang oleh setiap siswa, melainkan kartu milik temannya, kemudian siswa ditugaskan untuk mengamati Sumber Daya Alam hayati dan non hayati di rumah masing-masing beserta manfaatnya. 6) mencipta (C6), dengan model pembelajaran Take and Give dapat mendorong seluruh siswa menjadi lebih berkembang dan aktif dalam proses pembelajaran.
PENDEKATAN REALISTIC MATHEMATICS EDUCATION SEBAGAI SOLUSI UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA SISWA SEKOLAH DASAR PADA MATERI BANGUN DATAR PADA SISWA KELAS III SEKOLAH DASAR
Authors: Cipta Hendhisca , Haq Indri Nurul
Published: June 2023

Matematika merupakan pembelajaran yang penting dan harus dikuasai oleh setiap individu, karena pembelajaran matematika sangat bermanfaat bagi kehidupan sehari- hari. Penelitian ini bertujuan untuk meningkatkan kemampuan pemecahan masalah matematika siswa di sekolah dasar. Jenis penelitian ini menggunakan pendekatan kualitatif dan analisis data dengan mengumpulkan beberapa jurnal ilmiah sebagai pedomannya, dimana menekankan pada penyimpulan data berdasarkan perbandingan pustaka dalam jurnal ilmiah. Hasil penelitian menunjukan bahwa dengan menggunakan pendekatan Realistic Mathematics Education dapat meningkatkan kemampuan pemecahan masalah matematika siswa, dengan menggunakan pendekatan tersebut dapat melibatkan siswa secara aktif dalam pembelajaran, membantu mengembangkan kreatifivitas siswa dan juga rasa kepercayaan diri siswa dalam belajar, membantu siswa menemukan kembali suatu konsep pembelajaran melalui pengalaman sehari-hari, dan pembelajaran pun menjadi lebih bermakna karena siswa bisa membangun pengetahuannya sendiri untuk menemukan konsep dari materi yang dipelajari. Dengan demikian dapat disimpulkan bahwa dengan menerapkan pendekatan Realistic Mathematics Education dapat dijadikan sebagai solusi untuk meningkatkan kemampuan pemecahan masalah matematika di sekolah dasar.
Anabas testudineus(Bloch, 1792), climbing perch (Anabantidae), and its discovery in India
Authors: Zworykin Dmitry D.
Published: June 2023

This paper examines the history of discovery, early research and description of Anabas testudineus ( Bloch, 1792 ) (Anabantidae), an amphibious fish from southern India that was said to climb palm trees and so has been dubbed the “climbing perch”. Amphibious fishes constitute one of the most unusual groups of aquatic creatures since they can spend part of their life in terrestrial habitats. The first reports of such fishes date back to Antiquity, but with the onset of the Age of Discovery, naturalists were able to find actual examples of tropical amphibious fishes and send preserved specimens to Europe. A fish which could move overland and was rumoured to clamber up tree trunks became known to European naturalists through the efforts of a variety of people. Many of them were amateur naturalists whose main activities included politics, commerce and missionary work. The species was described by Marcus Elieser Bloch (1723–1799) in 1792, but this would not have been possible if the Reverend Christoph Samuel John (1747–1813) had not obtained specimens in India and sent them to Berlin. Around the same time, Lieutenant Dagobert Karl Daldorff ( fl. 1790–1802) documented the unusual amphibious behaviour of this fish. Thanks to others, Anabas testudineus was illustrated (albeit inaccurately) and the first scientific description published.
Alfonso Palanza (1851–1899): a late nineteenth-century Italian botanist and his herbaria
Authors: Pazienza Gaetano , Forte Luigi , Cavallaro Viviana
Published: June 2023

During his years in Naples, Alfonso Palanza (1851–1899) devoted himself to the study of the flora of Abruzzo and Naples and to the arrangement of his “Erbario Generale”. After moving to Apulia, he created the “Flora della Terra di Bari” herbarium. The “Erbario Generale” consists of approximately 7,000 specimens of both Italian and continental European origin, the latter from the mathematician Magnus Gustaf Mittag-Leffler (1846–1927). The “Flora della Terra di Bari” herbarium consists of 3,000 specimens from central Apulia. The excellent state of preservation of the specimens and the unique nature of those within the “Flora della Terra di Bari” herbarium clearly suggest that their floristic, taxonomic and nomenclatural study could provide a detailed picture of the floristic biodiversity of Apulia during the period when they were collected.
The Essential Elements of the PNF-concept, an Educational Narrative
Authors: Smedes Fred
Published: June 2023

Introduction: The term Proprioceptive Neuromuscular Facilitation (PNF) was introduced in the 1950s by Dr. Kabat and Mrs. Knott. From the mid-1950s the PNF-concept has been in a progressive development clarifying the use of techniques, performances and clinical applications. The concept of PNF was originally developed by Dr. Kabat and Mrs. Knott for rehabilitation purposes. The International PNF Association (IPNFA) consider themselves to be the official successor of Dr. Kabat and Mrs. Knott.

The PNF-concept evolved towards a comprehensive rehabilitation approach for various indications. There seems to be a misunderstanding about the PNF-concept, it is often seen as a basic stretching regime for wellbeing and general fitness. This has been criticized to avoid a confusion with the PNF-concept as a comprehensive rehabilitation approach.

Purpose: Providing a background with an explanation for the essential elements of the PNF-concept, being a total and comprehensive rehabilitation approach in physiotherapy and rehabilitation. The elements from the PNF-concept facilitate treatment effects in the fields of musculoskeletal and central neurological disorders and indications with a focus on motor learning.

Implications: The clarification of the essential elements from the PNF-concept in various fields of physiotherapy and physical rehabilitation will simplify how to transfer and incorporate the elements from the PNF-concept into individual treatments.
Preserving the Future through the Past: Unveiling the Role of Collective Memory in Conflict- Affected Communities.
Authors: Olumba Ezenwa
Published: June 2023

ing migration studies have neglected immobility and primarily focused on non-violent settings like IDP and refugee camps. However, in Africa’s Sahel region, characterised by violent conflicts between nomadic Fulani herders and sedentary farmers, little is known about the factors that influence and sustain immobility among conflict-affected communities. This paper examines the immobility experiences of farmers in conflict-affected communities in Nigeria, exploring why they choose to remain in their villages despite a lack of support from security agencies against non-state actor invasions. Conducted in May 2022, the study employs reflexive thematic analysis on data from 54 participants in Benue and Nasarawa states. Findings underscore the role of collective memory in shaping attachment to ancestral land and their adoption of immobility for its preservation. By addressing neglected factors in immobility within conflict-affected communities, this research contributes to the literature, emphasising the importance of understanding collective memory and its implications for contemporary behaviours.
Relações étnico-raciais e o trabalho com a Lei 10.639/03: análise de uma experiência com formação docente
Authors: Eugenio Benedito Gonçalves , Santana Fabiana
Published: June 2023

Este artigo aborda a importância e a aplicação da Lei 10639/03, que obriga os estabelecimentos de ensino públicos e privados a implementarem nos seus currí­culos a história e a cultura da África e dos afro-brasileiros. Apresenta em seu conteúdo o relato de uma experiência pedagógica. A experiência traz uma discussão sobre a problemática relativa à formação do professor, tomando como referência uma formação pedagógica promovida pela SMED de Vitória da Conquista e destinada a professores que trabalham com os conteúdos referentes à Cultura Africana. Diante disso, foi possí­vel observar quais os desafios enfrentados pelos professores que trabalham com a implementação da Lei 10639/03 nas escolas do municí­pio de Vitória da Conquista- Bahia.
Os três momentos pedagógicos no ensino de fí­sica: uma revisão sistemática de literatura
Authors: Bonfim Danúbia Damiana Santos , Nascimento William Júnior do
Published: June 2023

Este artigo visa investigar, por meio de uma revisão sistemática de literatura, a adoção da metodologia dos Três Momentos Pedagógicos no ensino de Fí­sica na Educação Básica. Para o delineamento da revisão, utilizou-se as bases de dados da Biblioteca Digital de Teses e Dissertações do Instituto Brasileiro de Informação, em Ciência e Tecnologia - IBICT, e os periódicos nacionais da área de Ensino de estratos restritos (A1, A2 e B1) direcionados para o ensino de Ciências/Fí­sica. Os resultados apontam uma escassez de trabalhos desenvolvidos sobre a temática no perí­odo de 2007 a 2017, refletindo a necessidade de pesquisas que se apropriem dessa proposta, a fim de contribuir para a sua disseminação, pois em um cenário na qual o ensino de Fí­sica anseia por novas práticas metodológicas, os Três Momentos Pedagógicos apresentam-se como um caminho para mudanças no ensino e aprendizagem de Fí­sica.
Chemotherapy efficacy in metastatic neuroendocrine colorectal cancer
Authors: Seidinovich A. , Gordeev S. S. , Markovich A. A. , Komarov I. G. , Alexancev D. V. , Mamedli Z. Z.
Published: June 2023

AIM: to evaluate the effectiveness of first-line chemotherapy in patients with colorectal neuroendocrine cancer (NEC).

PATIENTS AND METHODS: a retrospective study included patients with metastatic colorectal NEC (2000-2020). The main analyzed parameter was the response rate to treatment according to the RECIST criteria, depending on the regimen used in the first line. The overall survival was additional parameter.

RESULTS: the study included 27 patients (13 with initial stage IV disease and 14 with progression after primary radical treatment). Ten patients in the 1st line underwent chemotherapy according to the EP scheme, 4 — XELOX, 2 — FOLFIRI, 2 — Irinotecan and Cisplatin, 1 — Samarium, 1 — Nivolumab, 1 — 5-FU-LV. Most often, the treatment effect (partial response or stabilization) was observed against the background of chemotherapy according to the EP scheme — in 60% of patients. The median OS was 7 months.

CONCLUSION: the use of chemotherapy according to the EP regimen is the preferred options for the treatment of metastatic colorectal NEC. The median OS in this group of patients remains extremely low, and new clinical trials are needed.
Treatment of complications after surgery for Hirschsprung’s disease using posterior sagittal transanal approach (clinical observation)
Authors: Stepanova N. M. , Novozhilov V. A. , Zvonkov D. A. , Latynceva I.
Published: June 2023

The experience of complications treatment after surgery for Hirschsprung’s disease using posterior sagittal transanal approach is presented. It allows to obtain a sufficient overview of the main anatomical structures of the small pelvis in a “frozen pelvis” situation, helping to avoid their damage at the scar tissue changes.
Parastomal hernias: the current state (review)
Authors: Kopteev N. R. , Ovchinnikov T. S. , Lodygin A. V. , Bogatikov A. A. , Kashchenko V. A.
Published: June 2023

Every year there is an increase in the number of patients with intestinal stoma, which leads to an increase in the incidence of parastomal hernias (PSH). More than 50% of ostomy patients develop a parastomal hernia two or more years after radical surgery. To date, there are many surgical options for PSH, however, a unified algorithm for choosing an operational technique has not been evolved.

The purpose of this review is to study modern surgical methods for the treatment of PSH and their late results, to determine the optimal approach and benefits.

The review of the literature showed that in all cases of surgical treatment of PSH it is necessary to use mesh implants. The optimal technique for PSH hernioplasty is the laparoscopic version of Sugarbaker due to the low risk of recurrence and technical simplicity. In patients with large and giant PSH or hernia recurrence, STORRM is the technique of choice; classical stoma transposition is not used due to the high risk of recurrence. The use of Pauli/ePauli technique demonstrates a low recurrence rate, but there are no late results in this category of patients.
Transmucosal laser ablation for combined hemorrhoids of 2–3 stages
Authors: Matveev I. A. , Gibert B. K. , Matveev A. I. , Borodin N. A. , Morozova L. A. , Povarnin N. N.
Published: June 2023

AIM: to assess of the results of transmucosal laser ablation (TMLA) for internal piles and simultaneous elimination of external piles in patients with combined hemorrhoids of 2–3 stages.

PATIENTS AND METHODS: the retrospective study included 226 patients. TMLA of internal nodes with excision or destruction of external piles was performed in 136 patients (the main group) and 90 laser destructions of internal nodes only consisted the control group. The procedure was performed under local anesthesia on a Lakhta-Milon device with a wavelength of 1.47 μm with a power of 8.0 W. The operation time, the pain syndrome, its duration after surgery, the complication rate and the recurrence rate up to 18 months were estimated.

RESULTS: the operation time in the main group was 15.0 minutes (10 min in control group; p = 0.001), the pain intensity during procedure was determined by patients at 2.5 points of VAS (2.5 — in controls; p = 0.81). Postoperative pain was detected up to 6 days (5 days in controls; p = 0.44). Postoperative bleeding occurred in 4 (2.9%) (8 — in controls; p = 0.051), recurrence occurred in 3 (4.8%) patients after 12 months (1 patient in controls; p = 0.5).

СONCLUSION: TMLA has a good tolerability and good late results, which is the motivation for wide implementation for patients with hemorrhoids in outpatient basis.
AI-based algorithm for clinical decision support system in colonoscopy
Authors: Mtvralashvili D. A. , Shakhmatov D. G. , Likutov A. A. , Zapolsky A. G. , Suslova D. I. , Borodinov A. A. , Sushkov O. I. , Achkasov S. I.
Published: June 2023

AIM: to estimate the implementation of the original method that uses artificial intelligence (AI) to detect colorectal neoplasms.

MATERIALS AND METHODS: we selected 1070 colonoscopy videos from our archive with 5 types of lesions: hyperplastic polyp, serrated adenoma, adenoma with low-grade dysplasia, adenoma with high-grade dysplasia and invasive cancer. Then 9838 informative frames were selected, including 6543 with neoplasms. Lesions were annotated to obtain data set that was finally used for training a convolution al neural network (YOLOv5).

RESULTS: the trained algorithm is able to detect neoplasms with an accuracy of 83.2% and a sensitivity of 77.2% on a test sample of the dataset. The most common algorithm errors were revealed and analyzed.

CONCLUSION: the obtained data set provided an AI-based algorithm that can detect colorectal neoplasms in the video stream of a colonoscopy recording. Further development of the technology probably will provide creation of a clinical decision support system in colonoscopy.
Phaseolus vulgaris alphaendornavirus-1 is frequent in bean germplasm in Slovakia and shows low molecular variability
Authors: Mrkvová Michaela , Achs Adam , Alaxin Peter , Šubr Zdeno , Predajňa Lukáš , Zetochová Erika , Hauptvogel Pavol , Šoltys Katarína , Candresse Thierry , Glasa Miroslav
Published: June 2023

Phaseolus vulgaris alphaendornavirus-1 (PvEV-1, family Endornaviridae) was identified by ribodepleted total RNA high-throughput sequencing in the virome of two bean plants (Phaseouls vulgaris L.) grown in a garden in western Slovakia. Two nearly complete PvEV-1 genomes (ca. 14.06 kb, named PV1 and PV2) were assembled, showing 99.9% nucleotide identity, while their nucleotide identity with the reference PvEV-1 genome (NC_039217) reached 98.4%. Two primer pairs spanning the viral helicase encoding region and sequence upstream of the RNA-dependent RNA polymerase were designed and used to confirm the presence of the virus in the original bean samples by RT-PCR. A subsequent search for PvEV-1 presence in Slovakia was focused on two groups of samples: 1) bean plants grown under open field conditions and sampled during the vegetation period and 2) bean accessions grown from seeds obtained from a Slovak and French bean germplasm collection. Based on RT-PCR results, 4 out of 15 bean samples from open fields and 12 out of 21 bean accessions from the curated germplasm collection tested PvEV-1-positive. Interestingly, sequencing of RT-PCR products revealed that all amplified isolates are identical in the two amplified genomic portion which is also identical to those of the PV1 and PV2 isolates. These results suggest a relatively high incidence of PvEV-1 in bean in Slovakia. This is the first evidence and characterization of PvEV-1 from bean plants in Europe.
Application of multi-criteria decision analysis techniques and decision support framework for informing select agent designation for agricultural animal pathogens
Authors: Pillai Segaran P. , West Todd , Anderson Kevin , Fruetel Julia A. , McNeil Carrie , Hernandez Patricia , Ball Cameron , Beck Nataly , Morse Stephen A.
Published: June 2023

The United States Department of Agriculture (USDA), Division of Agricultural Select Agents and Toxins (DASAT) established a list of biological agents and toxins (Select Agent List) that potentially threaten agricultural health and safety, the procedures governing the transfer of those agents, and training requirements for entities working with them. Every 2 years the USDA DASAT reviews the Select Agent List, using subject matter experts (SMEs) to perform an assessment and rank the agents. To assist the USDA DASAT biennial review process, we explored the applicability of multi-criteria decision analysis (MCDA) techniques and a Decision Support Framework (DSF) in a logic tree format to identify pathogens for consideration as select agents, applying the approach broadly to include non-select agents to evaluate its robustness and generality. We conducted a literature review of 41 pathogens against 21 criteria for assessing agricultural threat, economic impact, and bioterrorism risk and documented the findings to support this assessment. The most prominent data gaps were those for aerosol stability and animal infectious dose by inhalation and ingestion routes. Technical review of published data and associated scoring recommendations by pathogen-specific SMEs was found to be critical for accuracy, particularly for pathogens with very few known cases, or where proxy data (e.g., from animal models or similar organisms) were used to address data gaps. The MCDA analysis supported the intuitive sense that select agents should rank high on the relative risk scale when considering agricultural health consequences of a bioterrorism attack. However, comparing select agents with non-select agents indicated that there was not a clean break in scores to suggest thresholds for designating select agents, requiring subject matter expertise collectively to establish which analytical results were in good agreement to support the intended purpose in designating select agents. The DSF utilized a logic tree approach to identify pathogens that are of sufficiently low concern that they can be ruled out from consideration as a select agent. In contrast to the MCDA approach, the DSF rules out a pathogen if it fails to meet even one criteria threshold. Both the MCDA and DSF approaches arrived at similar conclusions, suggesting the value of employing the two analytical approaches to add robustness for decision making.
Breast Tumor-Derived Exosomal MicroRNA-200b-3p Promotes Specific Organ Metastasis Through Regulating CCL2 Expression in Lung Epithelial Cells
Authors: Gu Pengfei , Sun Mayu , Li Lei , Yang Yang , Jiang Zheshun , Ge Yang , Wang Wenbo , Mu Wei , Wang Hui
Published: June 2023

Graphical Abstract

Schematic diagram of tumor-derived exosomes induced organotropism and immunosuppression.
Current understanding of disease control and its application in patients with chronic rhinosinusitis
Authors: Zhou Jiahui , Yuan Fan , Huang Tianhao , Zhu Li , Wu Dawei
Published: June 2023

Background

Disease control is a primary treatment goal for patients with chronic rhinosinusitis (CRS). This study aims to summarize the evaluation parameters of disease control and then identify predictors of poorly controlled CRS.

Methods

A systematic review of the literature was performed on PubMed, Google Scholar, Scopus, and Cochrane databases to identify studies relating to disease control in CRS.

Results

The concept of disease control in patients with CRS involved the longitudinal assessment of the disease state and was also an important goal of treatment. As a metric of the disease state, the disease control reflected the ability to keep disease manifestations within certain limits, the efficacy after treatment, and the impact on quality of life. Validated measurements, such as EPOS2012 criteria, EPOS2020 criteria, Sinus Control Test, and patient/physician-reported global level of CRS control, have been utilized in clinical practice. These existing disease control instruments incorporated various disease manifestations and categorized patients into two (well-controlled and poor-controlled), three (uncontrolled, partly controlled, and controlled), or five (not at all, a little, somewhat, very, and completely) control categories. Eosinophilia, high computerized tomography score, bilateral sinonasal disease, asthma, allergic rhinitis, female gender, aspirin intolerance, revision surgery, low serum amyloid A, and specific T cell subtype would predict poorly controlled CRS.

Conclusion

The concept of disease control and its application were gradually developed in patients with CRS. The existing disease control instruments demonstrated a lack of uniformity regarding the controlled criteria and included parameters.
Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis
Authors: Yang Xing , Mai Huanzhuo , Zhou Jie , Li Zhuoxin , Wang Qing , Lan Liuyan , Lu Fang , Yang Xiping , Guo Baodong , Ye Li , Cui Ping , Liang Hao , Huang Jiegang
Published: June 2023

Background

Gut microbiota is the largest population of microorganisms and is closely related to health. Many studies have explored changes in gut microbiota in viral hepatitis. However, the correlation between gut microbiota and the occurrence and progression of viral hepatitis has not been fully clarified.

Methods

PubMed and BioProject databases were searched for studies about viral hepatitis disease and 16S rRNA gene sequencing of gut microbiota up to January 2023. With bioinformatics analyses, we explored changes in microbial diversity of viral hepatitis, screened out crucial bacteria and microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting risks for the occurrence and progression of viral hepatitis based on ROC analysis.

Results

Of the 1389 records identified, 13 studies met the inclusion criteria, with 950 individuals including 656 patient samples (HBV, n = 546; HCV, n = 86; HEV, n = 24) and 294 healthy controls. Gut microbial diversity is significantly decreased as the infection and progression of viral hepatitis. Alpha diversity and microbiota including Butyricimonas, Escherichia-Shigella, Lactobacillus, and Veillonella were identified as the potential microbial markers for predicting the risk of development of viral hepatitis (AUC>0.7). Microbial functions including tryptophan metabolism, fatty acid biosynthesis, lipopolysaccharide biosynthesis, and lipid metabolism related to the microbial community increased significantly as the development of viral hepatitis.

Conclusions

This study demonstrated comprehensively the gut microbiota characteristics in viral hepatitis, screened out crucial microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting the risk of viral hepatitis.
Drug-coated balloon therapy is more effective in treating late drug-eluting stent in-stent restenosis than the early occurring one—a systematic review and meta-analysis
Authors: Kulyassa Péter , Engh Marie Anne , Vámosi Péter , Fehérvári Péter , Hegyi Péter , Merkely Béla , Édes István Ferenc
Published: June 2023

Drug-eluting stent in-stent restenosis (DES-ISR) remains one of the important assignments to be resolved in interventional cardiology, as it is present in 5%–10% of total percutaneous coronary intervention cases. Drug-coated balloon (DCB) utilization is promising, as it comes with long-term protection from recurrent restenosis in optimal conditions without the hazard of higher risk for stent thrombosis and in-stent restenosis. We aim to reduce the need for recurrent revascularization in DES-ISR, specifying the population in which the DCB therapy should be used. In this meta-analysis, the results of studies containing data on the time frame between drug-eluting stent implantation and the clinical presentation of in-stent restenosis and concomitant drug-coated balloon treatment were summarized. A systematic search was performed in Medline, Central, Web of Science, Scopus and Embase databases on November 11th, 2021. The QUIPS tool was used to assess the risk of bias in the included studies. The occurrence of a major cardiac adverse events (MACE) composite endpoint, containing target lesion revascularization (TLR), myocardial infarction, and cardiac death, and each of these separately, was assessed at 12 months after the balloon treatment. Random effects meta-analysis models were used for statistical analysis. Data of 882 patients from four studies were analyzed. Across the included studies, a 1.68 OR (CI 1.57–1.80, p < 0.01) for MACE and a 1.69 OR (CI 1.18–2.42 p < 0.01) for TLR were observed, both in favor of late DES-ISR. The main limitation of the study is the relatively low patient number. Nevertheless, this analysis shows the first statistically significant results for the effect of DCB treatment in the early or late presentation of DES-ISR. As to date, intravascular imaging (IVI) remains limitedly accessible, other landmarks as the time frame of in-stent restenosis development are to be pursued to advance therapeutic outcomes. In consideration of other biological, technical and mechanical factors, time frame of occurrence as a prognostic factor could reduce the burden of recurrent revascularization in patients at an already high risk.

Systematic Review Registration: identifier [CRD42021286262].
Role of G-protein coupled receptors in cardiovascular diseases
Authors: Li Yuanqiang , Li Boyu , Chen Wei-Dong , Wang Yan-Dong
Published: June 2023

Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an essential regulating cellular physiology and pathology. Some GPCR antagonists, such as β-blockers, are standard therapy for the treatment of CVDs. In addition, nearly one-third of the drugs used to treat CVDs target GPCRs. All the evidence demonstrates the crucial role of GPCRs in CVDs. Over the past decades, studies on the structure and function of GPCRs have identified many targets for the treatment of CVDs. In this review, we summarize and discuss the role of GPCRs in the function of the cardiovascular system from both vascular and heart perspectives, then analyze the complex ways in which multiple GPCRs exert regulatory functions in vascular and heart diseases. We hope to provide new ideas for the treatment of CVDs and the development of novel drugs.
Hypertensive heart disease: risk factors, complications and mechanisms
Authors: Masenga Sepiso K. , Kirabo Annet
Published: June 2023

Hypertensive heart disease constitutes functional and structural dysfunction and pathogenesis occurring primarily in the left ventricle, the left atrium and the coronary arteries due to chronic uncontrolled hypertension. Hypertensive heart disease is underreported and the mechanisms underlying its correlates and complications are not well elaborated. In this review, we summarize the current understanding of hypertensive heart disease, we discuss in detail the mechanisms associated with development and complications of hypertensive heart disease especially left ventricular hypertrophy, atrial fibrillation, heart failure and coronary artery disease. We also briefly highlight the role of dietary salt, immunity and genetic predisposition in hypertensive heart disease pathogenesis.
Growth response of syndromic versus non-syndromic children born small for gestational age (SGA) to growth hormone therapy: a Belgian study
Authors: Becker Marianne , Thomas Muriel , Brachet Cécile , Heinrichs Claudine , Dotremont Hilde , De Schepper Jean , Lysy Philippe , Beckers Dominique ,   the BESPEED group
Published: June 2023

Introduction

A substantial proportion of SGA patients present with a syndrome underlying their growth restriction. Most SGA cohorts comprise both syndromic and non-syndromic patients impeding delineation of the recombinant human growth hormone (rhGH) response. We present a detailed characterization of a SGA cohort and analyze rhGH response based on adult height (AH).

Methods

Clinical and auxological data of SGA patients treated with rhGH, who had reached AH, were retrieved from BELGROW, a national database of all rhGH treated patients held by BESPEED (BElgian Society for PEdiatric Endocrinology and Diabetology). SGA patients were categorized in syndromic or non-syndromic patients.

Results

272 patients were included, 42 classified as syndromic (most frequent diagnosis (n=6): fetal alcohol syndrome and Silver-Russell syndrome). Compared with non-syndromic patients, syndromic were younger [years (median (P10/P90)] 7.43 (4.3/12.37) vs 10.21 (5.43/14.03), p=0.0005), shorter (height SDS -3.39 (-5.6/-2.62) vs -3.07 (-3.74/-2.62), p=0.0253) and thinner (BMI -1.70 (-3.67/0.04) vs -1.14 (-2.47/0.27) SDS, p=0.0054) at start of rhGH treatment. First year rhGH response was comparable (delta height SDS +0.54 (0.24/0.94) vs +0.56 (0.26/0.92), p=0.94). Growth pattern differed with syndromic patients having a higher prepubertal (SDS +1.26 vs +0.83, p=0.0048), but a lower pubertal height gain compared to the non-syndromic group (SDS -0.28 vs 0.44, p=0.0001). Mean rhGH dose was higher in syndromic SGA patients (mg/kg body weight/day 0.047 (0.039/0.064) vs 0.043 (0.035/0.056), p=0.0042). AH SDS was lower in syndromic SGA patients (-2.59 (-4.99/-1.57) vs -2.32 (-3.3/-1.2), p=0.0107). The majority in both groups remained short (<-2 SDS: syndromic 71%, non-syndromic 63%). Total height gain was comparable in both groups (delta height SDS +0.76 (-0.70/1.48) vs +0.86 (-0.12/1.86), p=0.41).

Conclusions

Compared to non-syndromic SGA patients, syndromic SGA patients were shorter when starting rhGH therapy, started rhGH therapy earlier, and received a higher dose of rhGH. At AH, syndromic SGA patients were shorter than non-syndromic ones, but their height gain under rhGH therapy was comparable.
Assessing of programmed cell death gene signature for predicting ovarian cancer prognosis and treatment response
Authors: Lian Xin , Liu Bing , Wang Caixia , Wang Shuang , Zhuang Yuan , Li Xiao
Published: June 2023

Background

Programmed cell death (PCD) is an overwhelming factor affecting tumor cell metastasis, but the mechanism of PCD in ovarian cancer (OV) is still uncertain.

Methods

To define the molecular subtypes of OV, we performed unsupervised clustering based on the expression level of prognosis related PCD genes in the Cancer Genome Atlas (TCGA)-OV. COX and least absolute shrinkage and selection operator (LASSO) COX analysis were used to identify the OV prognostic related PCD genes, and the genes identified according to the minimum Akaike information criterion (AIC) were the OV prognostic characteristic genes. According to the regression coefficient in the multivariate COX analysis and gene expression data, the Risk Score of OV prognosis was constructed. Kaplan-Meier analysis was conducted to assess the prognostic status of OV patients, and receiver operating characteristic (ROC) curves were conducted to assess the clinical value of Risk Score. Moreover, RNA-Seq date of OV patient derived from Gene Expression Omnibus (GEO, GSE32062) and the International Cancer Genome Consortium (ICGC) database (ICGC-AU), verifying the robustness of the Risk Score via Kaplan-Meier and ROC analysis.Pathway features were performed by gene set enrichment analysis and single sample gene set enrichment analysis. Finally, Risk Score in terms of chemotherapy drug sensitivity and immunotherapy suitability was also evaluated in different groups.

Results

9-gene composition Risk Score system was finally determined by COX and LASSO COX analysis. Patients in the low Risk Score group possessed improved prognostic status, immune activity. PI3K pathway activity was increased in the high Risk Score group. In the chemotherapy drug sensitivity analysis, we found that the high Risk Score group might be more suitable for treatment with PI3K inhibitors Taselisib and Pictilisib. In addition, we found that patients in the low-risk group responded better to immunotherapy.

Conclusion

Risk Score of 9-gene composition of PCD signature possesses promising clinical potential in OV prognosis, immunotherapy, immune microenvironment activity, and chemotherapeutic drug selection, and our study provides the basis for an in-depth investigation of the PCD mechanism in OV.
Wind speed forecasting using optimized bidirectional LSTM based on dipper throated and genetic optimization algorithms
Authors: Alhussan Amel Ali , M. El-Kenawy El-Sayed , Abdelhamid Abdelaziz A. , Ibrahim Abdelhameed , Eid Marwa M. , Khafaga Doaa Sami
Published: June 2023

Accurate forecasting of wind speed is crucial for power systems stability. Many machine learning models have been developed to forecast wind speed accurately. However, the accuracy of these models still needs more improvements to achieve more accurate results. In this paper, an optimized model is proposed for boosting the accuracy of the prediction accuracy of wind speed. The optimization is performed in terms of a new optimization algorithm based on dipper-throated optimization (DTO) and genetic algorithm (GA), which is referred to as (GADTO). The proposed optimization algorithm is used to optimize the bidrectional long short-term memory (BiLSTM) forecasting model parameters. To verify the effectiveness of the proposed methodology, a benchmark dataset freely available on Kaggle is employed in the conducted experiments. The dataset is first preprocessed to be prepared for further processing. In addition, feature selection is applied to select the significant features in the dataset using the binary version of the proposed GADTO algorithm. The selected features are utilized to learn the optimization algorithm to select the best configuration of the BiLSTM forecasting model. The optimized BiLSTM is used to predict the future values of the wind speed, and the resulting predictions are analyzed using a set of evaluation criteria. Moreover, a statistical test is performed to study the statistical difference of the proposed approach compared to other approaches in terms of the analysis of variance (ANOVA) and Wilcoxon signed-rank tests. The results of these tests confirmed the proposed approach’s statistical difference and its robustness in forecasting the wind speed with an average root mean square error (RMSE) of 0.00046, which outperforms the performance of the other recent methods.
An evolution strategy of GAN for the generation of high impedance fault samples based on Reptile algorithm
Authors: Bai Hao , Jiang Wenxin , Du Zhaobin , Zhou Weixian , Li Xu , Li Hongwen
Published: June 2023

In a distribution system, sparse reliable samples and inconsistent fault characteristics always appear in the dataset of neural network fault detection models because of high impedance fault (HIF) and system structural changes. In this paper, we present an algorithm called Generative Adversarial Networks (GAN) based on the Reptile Algorithm (GANRA) for generating fault data and propose an evolution strategy based on GANRA to assist the fault detection of neural networks. First, the GANRA generates enough high-quality analogous fault data to solve a shortage of realistic fault data for the fault detection model’s training. Second, an evolution strategy is proposed to help the GANRA improve the fault detection neural network’s accuracy and generalization by searching for GAN’s initial parameters. Finally, Convolutional Neural Network (CNN) is considered as the identification fault model in simulation experiments to verify the validity of the evolution strategy and the GANRA under the HIF environment. The results show that the GANRA can optimize the initial parameters of GAN and effectively reduce the calculation time, the sample size, and the number of learning iterations needed for dataset generation in the new grid structures.
Challenges and responses of China’s energy legal system under the double carbon target
Authors: Huang Lansong , Wei Xuezhi , Wang Quansheng
Published: June 2023

The deep-seated problem of carbon neutrality is the energy problem, and the change in energy consumption structure determines the degree of achieving China’s double carbon target. The basic path to achieve the dual carbon goal is to realize the rule of law in energy governance, and the premise of the rule of law in energy governance is to establish a perfect energy legal system. In this paper, we use literary analysis to understand the current research status of this topic, normative and empirical analysis to understand the current legal norms and their implementation status of the implementation of the dual carbon goal in China, and comparative analysis to understand the construction status of the energy legal system of each country in achieving the dual carbon goal. In China, there are also problems such as the dilemma of energy law structure, the lack of dual-carbon legislative goals, the lack of basic framework laws, and the disconnection between energy laws and energy policies, etc. To remedy these dilemmas and shortcomings, the path of constructing a perfect energy law and regulation system is to: establish a Chinese energy development plan with dual-carbon goals; to formulate a basic energy law to lay the framework of China’s energy legal system; to establish the concepts and principles of energy legislation as the basis for maintaining a coordinated and unified energy legal system and so on.
Community structure and plant diversity under different degrees of restored grassland in mining areas of the Qilian Mountains, Northwestern China
Authors: Yang Xiaomei , Feng Qi , Liu Wei , Xia Honghua , Zhang Jutao , Yang Linshan , Zhang Chengqi , Wang Zhiyang , Feng Yonglin
Published: June 2023

Background: Mining activities are known to exert significant effects on the structure and function of grassland ecosystems. However, the role of mining grasslands restoration in altering the plant community and soil quality remains poorly understood, especially in alpine regions. Here, we investigated species diversity in grasslands with dynamic changes and different restoration levels in the Tianzhu alpine mining area locating in the Qilian Mountains.

Methods: The plant community structure and species composition of the grasslands with different restoration levels were analyzed by the sample method. We used five different restoration levels: very low recovered degree (VLRD), low recovered degree (LRD), medium recovered degree (MRD), and high recovered degree (HRD), and selected natural grassland (NGL, CK) as the control.

Results: Plant community structure and species composition were significantly higher than those under the VLRD in the Tianzhu alpine mining area (p < 0.05), with HRD > MRD > LRD > VLRD. There were 11 families, 18 genera, and 17 species of plants, mainly in the families of Leguminosae, Asteraceae, Gramineae, Rosaceae, and Salicaceae; among them, Salicaceae and Gramineae played a decisive role in the stability of the community. The ecotype community showed that perennial herbaceous plants were the most dominant, with annual herbaceous plants being the least dominant, and no tree and shrub layers were observed; the dominance index was the highest in VLRD at 0.32, the richness index was the highest in HRD at 2.73, the diversity of HRD was higher at 1.93, soil pH and EC showed a decreasing trend, and SMC, SOC, TN, NO3-N, NH4-N, AN, TP, and AP content showed an increasing trend with the increase of grassland restoration.

Conclusion: In summary, with the increase of restored grassland in the Tianzhu alpine mining area, plant diversity gradually increased and plant community structure gradually diversified, which was close to the plant diversity of NGL. The protection of partially VLRD and LRD grasslands in the mining area should be emphasized, and the mine grassland should be used rationally and scientifically restored.
Thriving in uncertainty: examining the relationship between perceived environmental uncertainty and corporate eco-innovation through the lens of dynamic capabilities
Authors: Han Xiang , Yue Beibei , He Zhiwei
Published: June 2023

Introduction: Objective environmental uncertainty has important impacts on entrepreneurial decision-making, but entrepreneurs’ perception of uncertainty may be a more crucial factor. This is because objective environmental uncertainty may need to be filtered through entrepreneurs’ perceptions to influence their decision-making. Therefore, exploring how entrepreneurs’ perceived environmental uncertainty (PEU) affects their corporate eco-innovation behavior has significant theoretical and practical implications.

Methods: Drawing on the dynamic capability view, we utilize data from the 2016 China Private Enterprise Survey (CPES) on 2,733 small and medium-sized enterprises (SEMs) to highlight the impact of entrepreneurs’ PEU on corporate eco-innovation. We also examine the moderating effect of government intervention (government subsidies and government official visiting) on this relationship.

Results: Our study reveals a positive impact of entrepreneurs’ PEU on corporate eco-innovation, confirming the critical role of dynamic capability in corporate strategic adjustment under uncertain conditions. Additionally, we find that government intervention (government subsidies and official visits) has a positive moderating effect on this relationship, with entrepreneurs’ PEU and eco-innovation being mediated by corporate dynamic capability.

Discussion: The study contributes to the literature on environmental uncertainty, dynamic capabilities, and eco-innovation, and provides practical implications for SMEs in developing countries. The findings highlight the importance of subjective perceptions of environmental uncertainty over objective uncertainty. The study also demonstrates that environmental uncertainty is not inherently negative, but can be managed strategically with dynamic adjustment and government support.