bluuebunny/crossref_metadata_2025 huggingface dataset:
Contrasting magmatic controls on the genesis of Fe-Ti-V oxide deposits in the Emeishan large igneous province using apatite Sr-Nd isotopes and apatite-zircon trace elements
Authors: Tang Qingyan , Li Chusi , Liu Cong , Xue Shengchao , Xu Shihai , Zhang Yan , Li Zhuoming , Bao Jian , Song Hong
Published: May 2023

We use Sr-Nd isotopes of apatite and trace element compositions of apatite-zircon pairs from a major ore layer in each of three selected magmatic Fe-Ti-V oxide ore deposits (Hongge, Panzhihua, and Taihe) in the Emeishan large igneous province (LIP) in southwestern China to contrast the magmatic controls on ore formation. The average contents of REEs in apatite from a representative ore zone/layer in each of these deposits are higher than the predicted values of apatite crystallizing from a melt with REE contents assumed to be the same as the average values of high-Ti basalts in the Emeishan LIP, confirming that the ore-forming magmas all experienced higher degrees of fractional crystallization by major silicate minerals than the average basalt. The apatites Sm/Yb and Sr/Y indicate that the Panzhihua magma was generated at a shallower depth and experienced higher degree of plagioclase fractional crystallization than Taihe and Hongge. The apatite Sr-Nd isotopes can be reproduced by ~ 8 wt% contamination with Precambrian gneiss-schist in the parental magma for Hongge and by ~ 10 wt% and ~ 25 wt% contamination with marbles in the parental magmas for Panzhihua and Taihe, respectively. A recycled, high-T altered oceanic gabbroic component in the mantle source is a viable alternative to the marble contamination model for Taihe. Coexisting zircon trace element compositions reveal that the parental magma for Taihe (ΔFMQ+4.0) is more oxidized than those for Hongge (ΔFMQ−0.4) and Panzhihua (ΔFMQ−0.7), questioning that magma oxidation played a critical role in the genesis of Fe-Ti-V oxide ore deposits in the Emeishan LIP.
Pediatric meniscus morphology varies with age: a cadaveric study
Authors: Rohde Matthew S. , Trivedi Sunny , Randhawa Sahej , Wright Christian E. , Vuong Brian B. , Pham Nicole , Stavinoha Tyler , Ellis Henry B. , Ganley Theodore J. , Green Daniel W. , Fabricant Peter D. , Tompkins Marc , Shea Kevin G.
Published: May 2023

Purpose

In adolescent patients, meniscal tear injury can occur either in isolation (e.g., discoid lateral meniscus tears) or in association with other traumatic injuries including tibial eminence fracture or ACL tear. Damage to meniscal integrity has been shown to increase contact pressure in articular cartilage, increasing risk of early onset osteoarthritis. In symptomatic patients failing conservative management, surgical intervention via meniscus repair or meniscus transplant is indicated. The purpose of this study was to evaluate the radial dimensions of pediatric menisci throughout development. The hypothesis was that the average radial meniscus dimensions will increase as specimen age increases, and mean medial and lateral region measurements will increase at a linear rate.

Methods

Seventy‐eight skeletally immature knee cadaver specimens under age 12 years were included in this study. The meniscal specimens were photographed in the axial view with ruler in the plane of the tibial plateau and analyzed using computer‐aided design (CAD) software (Autodesk Fusion 360). Measurements were taken from inner to outer meniscus rims at five 45 degree intervals using the clockface as a reference (12:00, 1:30, 3:00, 4:30, 6:00), and total area of meniscus and tibial plateau was recorded. Generalized linear models were used to evaluate the associations of radial width measurements with age, tibial coverage, and lateral vs. medial meniscus widths.

Results

All radial width measurements increased significantly with specimen age (p ≤ 0.002), and all lateral‐medial meniscal widths increased (p < 0.001). The anterior zones of the meniscus were found to increase at the slowest rate compared to other regions. Tibial plateau coverage was found to not significantly vary with age.

Conclusions

Meniscus radial width and lateral–medial meniscus width are related to age. The anterior width of the meniscus varied least with age. Improved anatomic understanding may help surgeons more effectively plan for meniscus repair, discoid resection/saucerization/repair, and also support appropriate selection of meniscus allograft for transplantation.
A new Lean tool for efficiency evaluation in SMED projects
Authors: Braglia Marcello , Di Paco Francesco , Marrazzini Leonardo
Published: May 2023

The ability of companies to rapidly conduct a changeover from one product to another as part of a production process is a fundamental step towards a more flexible production system that can deal with an increasingly dynamic and competitive market. Single-Minute Exchange of Die (SMED) is the best-known lean tool that aims to reduce time consumption in the changeover process. This paper presents a new lean tool called Set-up Saving Deployment (SSD), which improves set-up efficiency by classifying, analyzing, and removing set-up losses within a changeover process, and which supports decision-making for SMED implementation. SSD uses three matrices, constructed sequentially from the first (L-Matrix) to the last (ECE-Matrix), in order to assess the possible time savings that can be achieved by eliminating losses and, in addition, to forecast possible improvements resulting from implementing a SMED project. SSD also provides a new basket of tailored set-up efficiency indicators that allow the analysis team to correctly assess set-up efficiency and compare the “as is” condition with the subsequent “to be” condition from an operational perspective. The effectiveness of SSD in addressing set-up losses and predicting time savings is illustrated using an industrial case study of a resin-doming machine. Thanks to its structured step-by-step procedure, SSD significantly improves the efficiency of the changeover process.
The paint pot problem and common multiples in monoids
Authors: Zantema Hans , van Oostrom Vincent
Published: May 2023

Illustrated by a problem on paint pots that is easy to understand but hard to solve, we investigate whether particular monoids have the property of common right multiples. As one result we characterize generalized braid monoids represented by undirected graphs, being a subclass of Artin–Tits monoids. Stated in other words, we investigate to which graphs the old Garside result stating that braid monoids have the property of common right multiples, generalizes. This characterization also follows from old results on Coxeter groups and the connection between finiteness of Coxeter groups and common right multiples in Artin–Tits monoids. However, our independent presentation is self-contained up to some basic knowledge of rewriting, and also applies to monoids beyond the Artin–Tits format. The main new contribution is a technique to prove that the property of common right multiples does not hold, by finding a particular model, in our examples all being finite.
Intramuscular coherence enables robust assessment of modulated supra-spinal input in human gait: an inter-dependence study of visual task and walking speed
Authors: Zipser-Mohammadzada Freschta , Scheffers Marjelle Fredie , Conway Bernard A. , Halliday David M. , Zipser Carl Moritz , Curt Armin , Schubert Martin
Published: May 2023

Intramuscular high-frequency coherence is increased during visually guided treadmill walking as a consequence of increased supra-spinal input. The influence of walking speed on intramuscular coherence and its inter-trial reproducibility need to be established before adoption as a functional gait assessment tool in clinical settings. Here, fifteen healthy controls performed a normal and a target walking task on a treadmill at various speeds (0.3 m/s, 0.5 m/s, 0.9 m/s, and preferred) during two sessions. Intramuscular coherence was calculated between two surface EMG recordings sites of the Tibialis anterior muscle during the swing phase of walking. The results were averaged across low-frequency (5–14 Hz) and high-frequency (15–55 Hz) bands. The effect of speed, task, and time on mean coherence was assessed using three-way repeated measures ANOVA. Reliability and agreement were calculated with the intra-class correlation coefficient and Bland–Altman method, respectively. Intramuscular coherence during target walking was significantly higher than during normal walking across all walking speeds in the high-frequency band as obtained by the three-way repeated measures ANOVA. Interaction effects between task and speed were found for the low- and high-frequency bands, suggesting that task-dependent differences increase at higher walking speeds. Reliability of intramuscular coherence was moderate to excellent for most normal and target walking tasks in all frequency bands. This study confirms previous reports of increased intramuscular coherence during target walking, while providing first evidence for reproducibility and robustness of this measure as a requirement to investigate supra-spinal input.

Trial registration Registry number/ClinicalTrials.gov Identifier: NCT03343132, date of registration 2017/11/17.
TechnoSapiens: merging humans with technology in augmented reality
Authors: Rudolph Carsten , Brunnett Guido , Bretschneider Maximilian , Meyer Bertolt , Asbrock Frank
Published: May 2023

We present a marker-less AR/DR system that can replace the arm of the user with a virtual bionic prosthesis in real time including finger tracking. For this, we use a mixed reality HMD that provides the user with a stereo image based on video-see-through (VST). We apply chroma-keying to remove the user’s arm from each captured image and input reconstructed background information into the removed pixels. Before rendering the prosthesis model into the image, we re-target motion capture data of the user’s hand to the kinematic skeleton of the prosthesis to match the current hand pose. This system opens new research possibilities on self- and other-perception of bionic bodies. In a first evaluation study of the system, we propose that users perceive the virtual prosthesis model as a part of their body (i.e., that they experience a sense of ownership). We tested this assumption in a laboratory study with 27 individuals who used the system to perform a series of simple tasks in AR with their prosthesis. We measured body ownership and other measures with self-reports. In support of the hypothesis, users experienced a sense of body ownership. Also, a feeling of self-presence is induced during the task, and participants rated the overall experience as positive.
Temperature-specific spectral shift of luminescing thermally altered human remains
Authors: Schariatmadary Parnia , Aalders Maurice C. G. , Oostra Roelof-Jan , Krap Tristan
Published: May 2023

Human bone has shown to have luminescent properties that remain throughout the phases of cremation, with the exception of fully carbonized bone, when excited with a narrow band light source. During this research, an alternate light source (420–470nm, peak at 445nm) was used to visualize and investigate latent details relevant for forensic investigations of human remains recovered at fire scenes. As fire is a destructive force, it induces a vast variety of physical and chemical alterations to all components of the bone, making the subsequent analysis and interpretation of burned human remains challenging. A spectral shift in emission bandwidth, from green to red, was previously observed when the exposure temperature increased from 700 to 800 °C. This spectral shift was reproduced on a total of 10 human forearms, divided into 20 segments, by burning at 700 °C and 900 °C in an ashing furnace. The shift of emission bandwidth caused only by an increase in temperature was furthermore investigated by colorimetric analysis, proving the spectral shift to be significant. By easily quantifying the spectral shift, substantiation is provided for the use of this technique in practice to improve the interpretation of heat induced changes of bone.
Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers
Authors: Bede Peter , Lulé Dorothée , Müller Hans-Peter , Tan Ee Ling , Dorst Johannes , Ludolph Albert C. , Kassubek Jan
Published: May 2023

Background

The characterisation of presymptomatic disease-burden patterns in asymptomatic mutation carriers has a dual academic and clinical relevance. The understanding of disease propagation mechanisms is of considerable conceptual interests, and defining the optimal time of pharmacological intervention is essential for improved clinical trial outcomes.

Methods

In a prospective, multimodal neuroimaging study, 22 asymptomatic C9orf72 GGGGCC hexanucleotide repeat carriers, 13 asymptomatic subjects with SOD1, and 54 “gene-negative” ALS kindreds were enrolled. Cortical and subcortical grey matter alterations were systematically appraised using volumetric, morphometric, vertex, and cortical thickness analyses. Using a Bayesian approach, the thalamus and amygdala were further parcellated into specific nuclei and the hippocampus was segmented into anatomically defined subfields.

Results

Asymptomatic GGGGCC hexanucleotide repeat carriers in C9orf72 exhibited early subcortical changes with the preferential involvement of the pulvinar and mediodorsal regions of the thalamus, as well as the lateral aspect of the hippocampus. Volumetric approaches, morphometric methods, and vertex analyses were anatomically consistent in capturing focal subcortical changes in asymptomatic C9orf72 hexanucleotide repeat expansion carriers. SOD1 mutation carriers did not exhibit significant subcortical grey matter alterations. In our study, none of the two asymptomatic cohorts exhibited cortical grey matter alterations on either cortical thickness or morphometric analyses.

Discussion

The presymptomatic radiological signature of C9orf72 is associated with selective thalamic and focal hippocampal degeneration which may be readily detectable before cortical grey matter changes ensue. Our findings confirm selective subcortical grey matter involvement early in the course of C9orf72-associated neurodegeneration.
Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute calculous cholecystitis in patients over 90 years of age
Authors: Ramírez-Giraldo Camilo , Isaza-Restrepo Andrés , Rico-Rivera Enid Ximena , Vallejo-Soto Juan Carlos , Van-Londoño Isabella
Published: May 2023

Background

Laparoscopic cholecystectomy (LC) is the standard of care for acute calculous cholecystitis; however, in patients at high risk for surgery, particularly in the elderly, insertion of a percutaneous catheter drainage (PCD) at gallbladder is recommended. Current evidence suggests that PCD may have less favorable outcomes than LC, but also that LC-associated complications increase in direct relation to patient age. There is no recommendation supported by robust evidence to decide between one or the other procedure in super elderly patients.

Methods

A retrospective observational cohort study was designed to analyze the surgical outcomes of super elderly patients with cholecystitis who underwent LC versus PCD for treatment. The surgical outcomes of a subgroup of high-risk patients were also analyzed.

Results

A total of 96 patients who met the inclusion criteria between 2014 and 2021 were included. The median age of patients were 92 years (IQR: 4.00) with a female predominance (58.33%). The overall morbidity rate in the series was 36.45% and mortality rate was 7.29%. There was no statistically significant difference when compared to the associated morbidity and mortality among patients who underwent LC versus those who underwent PCD, neither in the analysis of the complete series or in the subgroup of high-risk patients.

Conclusions

The morbidity and mortality associated with the two most frequently recommended therapeutic options for operating super elderly patients with acute cholecystitis are high. We found no evidence of superiority in outcomes for either of the two procedures in this age group.
Adjuvant and neoadjuvant use of immune checkpoint inhibitors in NSCLC
Authors: Walia Anushka , Prasad Vinay
Published: May 2023

The neoadjuvant and adjuvant use of immune checkpoint inhibitors (ICIs) in early stage non-small cell lung cancer (NSCLC) is increasing, with pembrolizumab approved as adjuvant therapy following surgical resection and chemotherapy by the U.S. Food and Drug Administration in early 2023. However, clinical trials of these agents have several key limitations including the use of surrogate endpoints that have not been validated and a lack of demonstrated survival benefit. Further data supporting the benefits of ICIs in this setting are necessary to justify their use at the cost of greater financial burdens, time, and adverse effects.
Filamin-A-interacting protein 1 (FILIP1) is a dual compartment protein linking myofibrils and microtubules during myogenic differentiation and upon mechanical stress
Authors: Grande Valentina , Schuld Julia , van der Ven Peter F. M. , Gruss Oliver J. , Fürst Dieter O.
Published: May 2023

Variations in the gene encoding filamin-A-interacting protein 1 (FILIP1) were identified to be associated with a combination of neurological and muscular symptoms. While FILIP1 was shown to regulate motility of brain ventricular zone cells, a process important for corticogenesis, the function of the protein in muscle cells has been less well characterized. The expression of FILIP1 in regenerating muscle fibres predicted a role in early muscle differentiation. Here we analysed expression and localization of FILIP1 and its binding partners filamin-C (FLNc) and microtubule plus-end-binding protein EB3 in differentiating cultured myotubes and adult skeletal muscle. Prior to the development of cross-striated myofibrils, FILIP1 is associated with microtubules and colocalizes with EB3. During further myofibril maturation its localization changes, and FILIP1 localizes to myofibrillar Z-discs together with the actin-binding protein FLNc. Forced contractions of myotubes by electrical pulse stimulation (EPS) induce focal disruptions in myofibrils and translocation of both proteins from Z-discs to these lesions, suggesting a role in induction and/or repair of these structures. The immediate proximity of tyrosylated, dynamic microtubules and EB3 to lesions implies that also these play a role in these processes. This implication is supported by the fact that in nocodazole-treated myotubes that lack functional microtubules, the number of lesions induced by EPS is significantly reduced. In summary, we here show that FILIP1 is a cytolinker protein that is associated with both microtubules and actin filaments, and might play a role in the assembly of myofibrils and their stabilization upon mechanical stress to protect them from damage.
Modelling bivariate failure time data via bivariate extended Chen distribution
Authors: Kilany N. M. , El-Qareb F. G.
Published: May 2023

Fatal Shock, competing risks and stress models are utilized in reliability and survival analysis to characterize various application types. In this context, this paper aimed to introduce a new class of bivariate distribution based on the Marshall–Olkin type. The proposed distribution termed as the Bivariate Extended Chen (BEC) distribution so that the marginals have Extended Chen distribution. Some properties of this distribution are derived and explained. The BEC distribution parameters are estimated using the maximum likelihood method. Finally, two applications to real life applications highlight the significance and adaptability of the Bivariate Extended Chen (BEC) distribution. The BEC distribution offers a superior fit than different competing bivariate distributions, illustrating its flexibility and applicability in modelling.
Acute kidney injury: a strong risk factor for hypoglycaemia in hospitalized patients with type 2 diabetes
Authors: Carreira Ana , Castro Pedro , Mira Filipe , Melo Miguel , Ribeiro Pedro , Santos Lèlita
Published: May 2023

Aims

Acute kidney injury (AKI) is highly prevalent during hospitalization of patients with type 2 diabetes (T2D). We aimed to assess the impact of AKI and its severity and duration on the risk of hypoglycaemia in hospitalized patients with T2D.

Methods

Retrospective cohort analysis of patients with T2D, admitted at a University Hospital in 2018–2019. AKI was defined as an increase in serum creatinine by ≥ 0.3 mg/dl (48 h) or ≥ 1.5 times baseline (7 days), and hypoglycaemia as blood glucose concentration < 70 mg/dl. Patients with chronic kidney disease stage ≥ 4 were excluded. We registered 239 hospitalizations with AKI and randomly selected 239 without AKI (control). Multiple logistic regression was used to adjust for confounding factors and ROC curve analysis to determine a cutoff for AKI duration.

Results

The risk of hypoglycaemia was higher in the AKI group (crude OR 3.6, 95%CI 1.8–9.6), even after adjusting for covariates (OR 4.2, 95%CI 1.8–9.6). Each day of AKI duration was associated with a 14% increase in the risk of hypoglycaemia (95%CI 1.1–1.2), and a cutoff of 5.5 days of AKI duration was obtained for increased risk of hypoglycaemia and mortality. AKI severity was also associated with mortality, but showed no significant association with hypoglycaemia. Patients with hypoglycaemia had 4.4 times greater risk of mortality (95%CI 2.4–8.2).

Conclusions

AKI increased the risk of hypoglycaemia during hospitalization of patients with T2D, and its duration was the main risk factor. These results highlight the need for specific protocols to avoid hypoglycaemia and its burden in patients with AKI.
Aptamer-functionalized stir bar sorptive extraction for selective isolation, identification, and determination of concanavalin A in food by MALDI-TOF-MS
Authors: Vergara-Barberán María , Catalá-Icardo Mónica , Simó-Alfonso Ernesto F. , Benavente Fernando , Herrero-Martínez José Manuel
Published: May 2023

An aptamer-functionalized stir bar sorptive extraction (SBSE) coating is described for the first time devoted to selective isolation and preconcentration of an allergenic food protein, concavanalin A (Con A), followed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS) determination. For this purpose, the polytetrafluoroethylene surface of commercial magnetic stir bars was properly modified and vinylized to immobilize a thiol-modified aptamer against Con A via straightforward “thiol-ene” click chemistry. The aptamer-functionalized stir bar was employed as SBSE sorbent to isolate Con A, and several parameters that can affect the extraction efficiency were investigated. Under the optimized conditions, Con A was extracted and desorbed during 30 and 45 min, respectively, at 25 °C and 600 rpm. The SBSE MALDI-TOF-MS method provided limits of detection of 0.5 μg mL−1 for Con A. Furthermore, the SBSE coating was highly selective to Con A compared to other lectins. The developed method was successfully applied to the determination of low levels of Con A in several food matrices (i.e., white beans as well as chickpea, lentils, and wheat flours). Recoveries ranged from 81 to 97% with relative standard deviations below 7%. The aptamer-based stir bars presented suitable physical and chemical long-term stability (1 month) and a reusability of 10 and 5 extraction cycles with standards and food extracts, respectively. The developed aptamer-affinity extraction devices open up the possibility of developing novel highly selective SBSE coatings for the extraction of proteins and peptides from complex samples.

Graphical abstract
Microsurgical clipping as a retreatment strategy for previously ruptured aneurysms treated with the Woven EndoBridge (WEB) device: a mono-institutional case series
Authors: Kranawetter B. , Hernández S. , Mielke D. , Ernst M.S. , Malinova V. , Rohde V.
Published: May 2023

Background

Since its approval by the US Food and Drug Administration (FDA) in 2018, the flow disruptor Woven EndoBridge (WEB) device has become increasingly popular for the endovascular treatment of unruptured and ruptured cerebral aneurysms. However, the occlusion rates seem rather low and the retreatment rates rather high compared to other treatment methods. For initially ruptured aneurysms, a retreatment rate of 13 % has been reported. A variety of retreatment strategies has been proposed; however, there is a paucity of data concerning microsurgical clipping of WEB-pretreated aneurysms, especially previously ruptured ones. Thus, we present a single-center series of five ruptured aneurysms treated with the WEB device and retreated with microsurgical clipping.

Methods

A retrospective study including all patients presenting with a ruptured aneurysm undergoing WEB treatment at our institution between 2019 and 2021 was performed. Subsequently, all patients with an aneurysm remnant or recurrence of the target aneurysm retreated with microsurgical clipping were identified.

Results

Overall, five patients with a ruptured aneurysm treated with WEB and retreated with microsurgical clipping were included. Besides one basilar apex aneurysm, all aneurysms were located at the anterior communicating artery (AComA) complex. All aneurysms were wide-necked with a mean dome-to-neck ratio of 1.5. Clipping was feasible and safe in all aneurysms, and complete occlusion was achieved in 4 of 5 aneurysms.

Conclusions

Microsurgical clipping for initially ruptured WEB-treated aneurysms is a feasible, safe, and effective treatment method in well-selected patients.
Intruding into a conversation: how behavioral manipulation could support management of Xylella fastidiosa and its insect vectors
Authors: Avosani Sabina , Nieri Rachele , Mazzoni Valerio , Anfora Gianfranco , Hamouche Zeinab , Zippari Caterina , Vitale Maria Luisa , Verrastro Vincenzo , Tarasco Eustachio , D’Isita Ilaria , Germinara Salvatore , Döring Thomas F. , Belusic Gregor , Fereres Alberto , Thompson Vinton , Cornara Daniele
Published: May 2023

Behavioral manipulation (BM) is a multimodal control approach based on the interference with the stimuli mediating insect perception and interaction with the surroundings. BM could represent a win–win strategy for the management of vector-borne plant pathogens as the bacterium Xylella fastidiosa, since it could reduce the number of vectors alighting on host plants and, consequently, the chances for transmission to occur. In this review, we summarized current knowledge and highlighted gaps in information on (i) how insect vectors of X. fastidiosa in general, and more specifically the meadow spittlebug Philaenus spumarius, locate and accept the host plant; and (ii) how behavioral manipulation techniques could be applied to disrupt the vector–host plant interaction. Finally, we discussed how diverse BM strategies could be combined with other integrated pest management tools to protect olive groves from inoculation with the fastidious bacterium.
Pest science in Pasteur’s Quadrant
Authors: Mangel Marc
Published: May 2023

More than 25 years ago, Donald Stokes argued that we must move beyond the false dichotomy of basic or applied research and suggested that when considering a program of scientific research it is important to ask whether (i) the work is motivated by use and (ii) if there is a search for fundamental understanding. Giving yes/no answers to these questions allows us to characterize research more fully, replacing the “or” of “basic or applied” by a richer understanding of the process of science. Stokes proposed that research that was motivated by a consideration of use and sought fundamental understanding be called research in Pasteur’s Quadrant. One advantage of such work is that the search for fundamental understanding means that the problem-solving tools are more likely to be transferrable. After reviewing Stokes’s formulation of research, I illustrate it with examples from the control of tephritid flies and the use of insect parasitoids for biological control. Thinking about one’s work within Stokes’s framework has many advantages for individual scientists, including guidance for journal selection, how to organize and conclude papers and seminars, and the “elevator speech.” Furthermore, since research in Pasteur’s Quadrant has the characteristic of simultaneously increasing our understanding of how the world works and improving applications, it will more likely benefit the community of pest scientists.
Measuring the missing: Knowledge, risk perceptions and self-protection practices of COVID-19 among the Asian population in New Zealand: An online survey
Authors: Liu Liangni Sally , Jia Xiaoyun , Zhu Andrew , Ran Guanyu Jason , Johnston David , Siegert Richard , Gong Yuan , French Nigel , Lu Jun
Published: May 2023

Aim

Asians are the second largest and fastest growing non-European population in New Zealand but are under-researched in terms of their COVID-19 pandemic response. The paper aims to illustrates Asians’ risk perceptions and knowledge of COVID-19, and self-protection practices to avoid infection and prevent community transmission.

Subject and methods

An online survey was used to collect data and received 402 valid responses. Data analyses included: 1) a descriptive analysis by using Chi-square tests and a Kruskal-Wallis rank sum tests to explore associations between responses and the four demographic variables (i.e. age, gender, country of origin/ethnicity, and region); and 2) a correlation analysis between different survey objectives.

Results

The descriptive analysis of the survey found that while ethnicity (within the Asian category) was the most influential variable that resulted in varying responses to many questions, gender and age were other two important variables in influencing the answering patterns. The correlation analysis found a positive correlation between the perceived ‘dangerousness’ of COVID-19 and respondents’ overall compliance behaviour to New Zealand authorities’ recommendations to prevent spread of COVID-19.

Conclusion

The majority of the respondents provided correct answers to the questions about the vulnerable populations, symptoms, asymptomatic transmission and potential sequelae of COVID-19; however, their understanding of the availability of a cure for, and the incubation period of COVID-19 was not consistent with the official information. The research also found that the higher perceived dangerousness of COVID-19, the better compliance to self-protection practices among the surveyed population.
Websites’ data: a new asset for enhancing credit risk modeling
Authors: Crosato Lisa , Domenech Josep , Liberati Caterina
Published: May 2023

Recent literature shows an increasing interest in considering alternative sources of information for predicting Small and Medium Enterprises default. The usage of accounting indicators does not allow to completely overcome the information opacity that is one of the main barriers preventing these firms from accessing to credit. This complicates matters both for private lenders and for public institutions supporting policies. In this paper we propose corporate websites as an additional source of information, ready to be exploited in real-time. We also explore the joint use of online and offline data for enhancing correct prediction of default through a Kernel Discriminant Analysis, keeping the Logistic Regression and the Random Forests as benchmark. The obtained results shed light on the potentiality of these new data when accounting indicators lead to a wrong prediction.
A Priori Direct Numerical Simulation Assessment of MILD Combustion Modelling in the Context of Reynolds Averaged Navier–Stokes Simulations
Authors: Awad Hazem S. A. M. , Abo-Amsha Khalil , Ahmed Umair , Swaminathan Nedunchezhian , Chakraborty Nilanjan
Published: May 2023

A priori Direct Numerical Simulation (DNS) assessment of mean reaction rate closures for reaction progress variable in the context of Reynolds Averaged Navier–Stokes (RANS) simulations has been conducted for MILD combustion of homogeneous (i.e., constant equivalence ratio), methane-air mixtures. The reaction rate predictions according to statistical (e.g., presumed probability density function), phenomenological (e.g., eddy-break up (EBU), eddy dissipation concept (EDC) and the scalar dissipation rate (SDR) based approaches), and flame surface description (e.g., Flame Surface Density) based closures are compared. The performance of the various reaction rate closures has been assessed by comparing the models’ predictions to the corresponding quantities extracted from DNS data. It has been found that the usual presumed probability density function (PDF) approach using the beta-function predicts the PDF of the reaction progress variable in homogenous mixture MILD combustion throughout the flame brush for all cases considered here provided that the scalar variance is accurately predicted. The accurate estimation of scalar variance requires the solution of a modelled transport equation, which depends on the closure of Favre-averaged SDR. A linear relaxation based algebraic closure for the Favre-averaged SDR has been found to capture the behaviour of the Favre-averaged SDR in the current homogenous mixture MILD combustion setup. It has been found that the EBU, SDR and FSD-based mean reaction rate closures do not adequately predict the mean reaction rate of the reaction progress variable for the parameter range considered here. However, a variant of the EDC closure, with model coefficients expressed as functions of micro-scale Damköhler and turbulent Reynolds numbers, has been found to be more successful in predicting the mean reaction rate of reaction progress variable compared to other modelling methodologies for the range of turbulence intensities and dilution levels considered here.
Assessment of right ventricular structure and systolic function in amateur marathon runners using three-dimensional speckle tracking echocardiography
Authors: Hu Shanting , Zhang Hebin , Ma Hui , Yang Cunxin , Hu Peipei , Gao Feng
Published: May 2023

Prolonged high-intensity endurance exercise has been reported to have adverse effects on the heart, which are further correlated with exercise dose. However, its effect on the right ventricle (RV) of amateur runners is unknown. This study aimed was to evaluate the early right ventricular structure and systolic function of amateur marathon runners by three-dimensional speckle tracking echocardiography (3D-STE), and to further analyze the correlation between relevant parameters and the amount of training. A total of 30 amateur marathon runners (marathon group) and 27 healthy volunteers (control group) were enrolled. Conventional echocardiography combined with 3D-STE was performed in all subjects, and the marathon group was screened by echocardiography a week before a marathon (V1), within 1 h post-marathon (V2), and 4 days post-marathon (V3). RV global longitudinal strain (GLS) and RV end-diastolic volume (EDV) increased significantly in the marathon group compared to the control group (P < 0.05). RV GLS was significantly decreased in the marathon group within 1 h post-marathon (V1: − 26.2 ± 2.5% vs V2: − 23.0 ± 1.6% vs V3: − 25.6 ± 2.6%, P < 0.001). However, there was no significant difference in RV ejection fraction (RVEF) (P > 0.05). The results of the correlation analysis showed that RV EDV and RV end-systolic volume (ESV) were positively correlated with the average training volume (P < 0.001). Multivariate linear regression analysis showed that average training volume was an independent predictor of RV EDV in amateur marathoners (β = 0.642, P < 0.001). The systolic function of the RV was enhanced in amateur marathon runners in the early stage, manifested by an increase in RV EDV. After a long period of high-intensity endurance exercise, RV systolic function will temporarily be reduced. 3D-STE can identify this subclinical change with high sensitivity and provide valuable information to assess the structure and function of RV in amateur marathon runners.
Sparse conic reformulation of structured QCQPs based on copositive optimization with applications in stochastic optimization
Authors: Gabl Markus
Published: May 2023

Recently, Bomze et al. introduced a sparse conic relaxation of the scenario problem of a two stage stochastic version of the standard quadratic optimization problem. When compared numerically to Burer’s classical reformulation, the authors showed that there seems to be almost no difference in terms of solution quality, whereas the solution time can differ by orders of magnitudes. While the authors did find a very limited special case, for which Burer’s reformulation and their relaxation are equivalent, no satisfying explanation for the high quality of their bound was given. This article aims at shedding more light on this phenomenon and give a more thorough theoretical account of its inner workings. We argue that the quality of the outer approximation cannot be explained by traditional results on sparse conic relaxations based on positive semidenifnite or completely positive matrix completion, which require certain sparsity patterns characterized by chordal and block clique graphs respectively, and put certain restrictions on the type of conic constraint they seek to sparsify. In an effort to develop an alternative approach, we will provide a new type of convex reformulation of a large class of stochastic quadratically constrained quadratic optimization problems that is similar to Burer’s reformulation, but lifts the variables into a comparatively lower dimensional space. The reformulation rests on a generalization of the set-completely positive matrix cone. This cone can then be approximated via inner and outer approximations in order to obtain upper and lower bounds, which potentially close the optimality gap, and hence can give a certificate of exactness for these sparse reformulations outside of traditional, known sufficient conditions. Finally, we provide some numerical experiments, where we asses the quality of the inner and outer approximations, thereby showing that the approximations may indeed close the optimality gap in interesting cases.
Gradient Robust Mixed Methods for Nearly Incompressible Elasticity
Authors: Basava Seshadri R. , Wollner Winnifried
Published: May 2023

Within the last years pressure robust methods for the discretization of incompressible fluids have been developed. These methods allow the use of standard finite elements for the solution of the problem while simultaneously removing a spurious pressure influence in the approximation error of the velocity of the fluid, or the displacement of an incompressible solid. To this end, reconstruction operators are utilized mapping discretely divergence free functions to divergence free functions. This work shows that the modifications proposed for Stokes equation by Linke (Comput Methods Appl Mech Eng 268:782–800, 2014) also yield gradient robust methods for nearly incompressible elastic materials without the need to resort to discontinuous finite elements methods as proposed in Fu et al. (J Sci Comput 86(3):39–30, 2021).
Cultural Stress Profiles: Describing Different Typologies of Migration Related and Cultural Stressors among Hispanic or Latino Youth
Authors: Zeledon Ingrid , Unger Jennifer B. , Meca Alan , Duque Maria , Lee Ryan , Soto Daniel W. , Pickering Trevor , Schwartz Seth J.
Published: May 2023

Youth of immigrant origin vary across their families’ migration history (e.g., country of heritage, reasons for migration, etc.) and in the communities in which they reside. As such, these youth are often faced with different cultural and immigrant stressors. Although prior research documented the detrimental impact of cultural and immigrant stressors, variable-centered approaches fail to account for the fact that these stressors often co-occur. Addressing this gap, the current study identified typologies of cultural stressors in Hispanic/Latino adolescents using latent profile analysis. Cultural stress profiles were derived using socio-political stress, language brokering, in-group identity threats, and within-group discrimination as indicators. The study was conducted in two sites (Los Angeles and Miami; total N = 306) during Spring and Summer 2020. A four-profile solution was identified: Low Cultural Stress (n = 94, 30.7%), Sociopolitical and Language Brokering Stress (n = 147, 48%), Sociopolitical and In-group Identity Threat Stress (n = 48, 15.7%), and Higher Stress (n = 17, 5.6%). Results indicate that profiles with stress were characterized by worse mental health symptoms, reporting higher means of depression, stress, and lower self-esteem, as well as by higher heritage cultural orientation compared to the low stress profile. Interventions designed to mitigate the deleterious effects of cultural stressors would benefit from adopting an individualized, tailored approach that addresses youth’s stress profile membership.
The vertebrate muscle superlattice: discovery, consequences, and link to geometric frustration
Authors: Millane Rick P. , Luther Pradeep K.
Published: May 2023

Early x-ray diffraction studies of muscle revealed spacings larger than the basic thick filament lattice spacing and led to a number of speculations on the mutual rotations of the filaments in the myosin lattice. The nature of the arrangements of the filaments was resolved by John Squire and Pradeep Luther using careful electron microscopy and image analysis. The intriguing disorder in the rotations, that they termed the myosin superlattice, remained a curiosity, until work with Rick Millane and colleagues showed a connection to “geometric frustration,” a well-known phenomenon in statistical and condensed matter physics. In this review, we describe how this connection gives a satisfying physical basis for the myosin superlattice, and how recent work has shown relationships to muscle mechanical behaviour.
Adaptation and illness severity: the significance of suffering
Authors: Jølstad Borgar
Published: May 2023

Adaptation to illness, and its relevance for distribution in health care, has been the subject of vigorous debate. In this paper I examine an aspect of this discussion that seems so far to have been overlooked: that some illnesses are difficult, or even impossible, to adapt to. This matters because adaptation reduces suffering. Illness severity is a priority setting criterion in several countries. When considering severity, we are interested in the extent to which an illness makes a person worse-off. I argue that no plausible theory of well-being can disregard suffering when determining to what extent someone is worse-off in terms of health. We should accept, all else equal, that adapting to an illness makes the illness less severe by reducing suffering. Accepting a pluralist theory of well-being allows us to accept my argument, while still making room for the possibility that adaptation is sometimes, all things considered, bad. Finally, I argue that we should conceptualize adaptability as a feature of illness, and thereby account for adaptation on a group level for the purposes of priority setting.
The Timing of Technology Adoption in Network Industries
Authors: Wang Leonard F. S. , Buccella Domenico
Published: May 2023

This paper analyzes the effect of network externalities on firms’ timing of new technology adoption in a network industry. In a pre-commitment game under Cournot competition, network effects tend to accelerate the timing of the leader and the follower regarding their adoption dates: under the rational expectations hypothesis and also under the firms’ output commitment. However, while an increase in network effects tends to reduce the discrepancy between the optimal social timing of the new technology adoption and the market-driven time of adoption in the rational expectations model, the opposite occurs under the output commitment game.
Paradoxes of accelerator programs and new venture performance: Do varieties of experiences make a difference?
Authors: Chowdhury Farzana , Audretsch David B.
Published: May 2023

Incubators and accelerators have proliferated, but their impact on new ventures’ performance remains unclear. This article explores whether all ventures benefit equally from participating in accelerator programs. We propose that the entrepreneurs’ human capital resources influence the benefits extracted from accelerator program participation. Using application data from the accelerator programs across developed and developing countries, we find participation in accelerator programs positively impacts the ventures’ innovation performance but has a mixed impact on social performance. Founders with high education benefit from participating in accelerator programs for innovation and social performance. However, entrepreneurial experience and vast industry experience do not significantly influence ventures’ social and innovation-related performance from accelerator participation. The result is consistent for both solo and team founders.
Let’s Talk About Single Men: A Qualitative Investigation of Never Married Men’s Experiences of Singlehood
Authors: Mrozowicz-Wrońska Marta , Janowicz Kamil , Soroko Emilia , Adamczyk Katarzyna
Published: May 2023

Existing research on singlehood has largely focused on the experiences of single women, and little is known about singlehood among men. The current investigation examined the experience of long-term singlehood through individual, semi-structured interviews with 22 never-married single men living in Poland who were aged 22–43 years. Thematic analysis revealed five key themes: (1) the sense of being deficient—is there something wrong with me?; (2) navigating outside the dominant discourse of traditional masculinity, marriage and family; (3) the benefits and downsides of singlehood; (4) adaptation to singlehood; and (5) the dilemma between waiting and actively searching for a romantic partner. An analysis of single men’s narratives revealed that men experience their single status in the context of their various needs and hopes and as a status that determines their adult life course. This study contributes to the singlehood literature, highlighting the complexity of singlehood for men and the importance of traditional masculinity norms in experiencing long-term singlehood.

These findings challenge stereotypical and unrealistic views of singlehood among men and have practical implications for psychotherapists, counsellors and educators working with single men.
Refugees as Skilled Migrants: Insights from Australia’s 2018 Employer-Sponsored Refugee Migration Pilot
Authors: Higgins Claire , Baker Sally , Cousins Stephanie , Wang Ben Zhe , Cheng Zhiming , Tani Massimiliano , Jack Victoria
Published: May 2023

Many of the more than 27 million refugees in the world today are highly educated professionals, but resolving their displacement via skilled migration pathways is typically not possible. At the request of employers facing severe skill shortages and the coordination of Talent Beyond Boundaries (TBB)–a non-profit organisation–the Australian government introduced in 2018 a pilot program enabling employers to sponsor refugees through an employment contract meeting existing skilled visa requirements. The pilot effectively added immigration places to refugees, as employer-sponsored visa are uncapped in Australia. We highlight some insights collected from TBB’s 2018 and subsequent pilots.