bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-world Accuracy of CGM in Inpatient Critical and Noncritical Care Settings at a Safety-Net Hospital
Authors: Finn Erin , Schlichting Lindsay , Grau Laura , Douglas Ivor S. , Pereira Rocio I.
Published: August 2023

OBJECTIVE

We sought to determine real-world accuracy of inpatient continuous glucose monitoring (CGM) at multiple levels of acuity in a large safety-net hospital.

RESEARCH DESIGN AND METHODS

We analyzed records from hospitalized patients on Dexcom G6 CGM, including clinical, point of care (POC), and laboratory (Lab) glucose, and CGM data. POC/Lab values were matched to the closest timed CGM value. Encounters were divided into not critically ill (NCI) versus critically ill (CI). CGM accuracy was evaluated.

RESULTS

Paired readings (2,744 POC-CGM; 3,705 Lab-CGM) were analyzed for 233 patients with 239 encounters (83 NCI, 156 CI). POC-CGM aggregated and average mean absolute relative differences (MARD) were 15.1% and 17.1%. Lab-CGM aggregated and average MARDs were 11.4% and 12.2%. Accuracy for POC-CGM and Lab-CGM was 96.5% and 99.1% in Clarke Error Grid zones A/B.

CONCLUSIONS

Real-world accuracy of inpatient CGM is acceptable for NCI and CI patients. Further exploration of conditions associated with lower CGM accuracy in real-world settings is warranted.
Effect of Pyriproxyfen, a Malaria Vector Larvicide, on the Growth and Mortality of Vannamei Shrimp
Authors: Putri Sriana , Setyaningrum Endah , Farisi Salman
Published: August 2023

Anopheles mosquito shared a breeding site with the vannamei shrimp (Litopenaeus vannamei). Anopheles mosquito larvae commonly live in both stagnant fresh and brackish water. The potential breeding habitat of Anopheles mosquito larvae may be rice fields, pools or ponds, swamps, ditches, and slow-current streams. One of the effective strategies to control malaria is to apply chemical insecticides. Pyriproxifen is a larvicide that contains juvenile hormone-like compounds. Juvenile hormone-like compounds can affect mosquito morphogenesis, characterized by the failure of the larvae to develop into pupae. With a completely randomized design, the shrimp fry was divided into 4 groups,  6 repetitions, 20 individuals each. Shrimp fry in each experimental unit was placed and maintained in plastic jars containing 2.5 L of brackish water. The results showed that the insect growth regulator (IGR) with the active ingredient pyriproxyfen at various concentrations had no significant effect on the growth, mortality, and survival of vannamei shrimp fry.  It can be concluded therefore that pyriproxifen larvicide was safe to be used for controlling malaria mosquito vectors in hatcheries and breeding ponds of vannamei shrimp.
Local Wisdom Of The People Of Kemlaten Village Parengan Sub-District In Utilizing Wild Plants
Authors: Aprilia Diah Ayu , Cintamulya Imas
Published: August 2023

The community of Kemlaten village has a habit of using wild plants as food and medicine. The purpose of this study was to describe the types of wild plants used by the Kemlaten village community, Parengan District, as food and medicine and as well as their morphology. This quantitative descriptive study was conducted in March-April 2022 in the Kemlaten village area. The results of the study showed that there were 25 species of wild plants used as food and medicine by the Kemlaten villagers. Of the 25 wild plant species, 32% are used as food and 68% as medicine. The results of the morphological analysis of wild plants used as food and medicine by the villagers of Kemlaten are dominated by single-leaf plants and woody stems. The morphology of these wild plants differs from one another according to the type or family of these wild plants.
Characterization of Phosphate Solubilizing Bacteria from Three Types of Soil Rhizosphere and Their Potency to Increase Growth of Corn Plants (Zea mays)
Authors: Rosita Risa , Apriana Edwin , Hazra Fahrizal , Eris Deden Dewantara
Published: August 2023

Pemberian dosis pupuk P (fosfat) yang tinggi tidak sejalan dengan ketersediaan P dalam tanah karena sebagian besar P terikat oleh Al, Fe dan Ca sehingga tidak tersedia bagi tanaman. Pemanfaatan mikrob pelarut P merupakan salah satu upaya dalam meningkatkan ketersediaan P yang dapat diserap oleh tanaman. Tujuan dari penelitian ini adalah untuk mengisolasi, mengkarakterisasi dan menguji potensi mikroba pelarut P yang diisolasi dari tiga jenis rizosfer. Penelitian menggunakan Rancangan Acak Lengkap (RAL) satu faktorial. Serangkaian karakterisasi melalui uji hipersensitivitas, uji pewarnaan gram, uji katalase, uji oksidase, uji kebutuhan oksigen, uji motilitas, kemampuan menggunakan berbagai sumber karbon (glukosa, laktosa, dan sukrosa), uji metil merah, dan uji pertumbuhan pada berbagai pH . Hasil penelitian menunjukkan sebanyak 5 bakteri pelarut P terpilih (Ca-Al-7, Ca-Al-8, Ca-Al-4, Ca-NF-1, dan Ca-NF-3) bukan patogen tanaman, dengan nilai kelarutan fosfat berturut-turut 1,7; 2,9; 2,5; 3,1; 3,2 berpengaruh nyata terhadap parameter tinggi tanaman, jumlah daun, biomassa segar dan kering tanaman Zea mays setelah inokulasi 4 minggu (p < 0,05).
Effect Concentration of Teak Leaf Extract on the Diameter of the Inhibitory Zone Xanthomonas oryzae
Authors: Prasetyo Hidayat Nur , Pantiwati Yuni , Chamisijatin Lise
Published: August 2023

Indonesia is an agricultural country with the majority of the population working in the agricultural sector. According to the Central Statistics Agency of Indonesia, rice production in 2022 is estimated at 9.58 million tons, down by 0.04 million tons or 0.41 percent compared to 2021 which was around 9.62 million tons. The rise and fall of rice production was influenced by several problems. One of the causes of the delay in rice production is leaf blight caused by Xanthomonas oryzae pv. oryzae reducing rice yields by 30-40%. This research was to examine the use of teak leaf extract in inhibiting the growth of X. oryzae bacteria. The results showed that there was an effect of various concentrations of teak leaf extract (Tectona grandis) on the inhibition zone of X. oryzae. The effective concentration of teak leaf extract in inhibiting Xanthomonas oryzae bacteria is 20%.
Pengembangan Media Video Pembelajaran pada Mata Pelajaran IPAS Materi Perubahan Wujud Zat Kelas IV SD
Authors: Sonia Gina , Hidayati Abna , Syafril Syafril , Supendra Dedi
Published: August 2023

Berdasarkan observasi pada proses pembelajaran IPAS, permasalahan terkait ketidakpahaman materi siswa SDN 12 Tapi Selo kelas IV disebabkan pembelajaran yang monoton selain itu guru jarang menggunakan media saat kegiatan pembelajaran. Oleh karena itu penelitian ini bertujuan mengembangkan video edukasi sebagai sumber belajar yang dapat mewujudkan hal-hal nyata pembelajaran IPAS kelas IV untuk menghasilkan media pembelajaran yang valid, praktis dan efektif untuk dimanfaatkan oleh pendidik dan peserta didik. Jenis penelitian ini adalah R&D dengan menggunakan model four D (4 D). Penelitian ini terdiri dari 6 fase, yaitu. mendefinisikan, merancang, mengembangkan, menyebarluaskan. Uji validitas media dilakukan oleh tiga ahli yaitu validator materi guru IPAS SDN 12 Tapi Selo dan dua validator media dari dosen Departemen Kurikulum dan Teknologi Pendidikan Universitas Negeri Padang. Ujian praktikalitas dilaksanakan untuk peserta didik kelas IV SDN 12 Tapi Selo. Berdasarkan penilaian validator media dan materi, hasil validasi materi 97,5% tergolong “Sangat Valid”, 99% hasil validasi media I tergolong “Sangat Valid” dan 95,8% hasil validasi materi II tergolong “Sangat Valid”. Media video ini tergolong “sangat praktis” dengan nilai 96,9%.
Analisis Emisi Gas Buang (CO, CO2 dan HC) pada Sepeda Motor FI dengan Variasi Saat Pengapian, Saat Penginjeksian dan Jenis Bahan Bakar
Authors: Firmansyah M. Sadly , Wawan Purwanto  , Hasan Maksum  , Ahmad Arif  , M. Yasep Setiawan
Published: August 2023

Penelitian ini membahas tentang perubahan nilai kadar CO, CO2 dan HC yang dihasilkan emisi gas buang pada  sepeda motor FI dengan penggunaan ECU Programmable (4 variasi perlakuan saat pengapian dan saat penginjeksian) menggunakan 3 jenis bahan bakar di setiap perlakuan . Tujuan penelitian ini adalah mengetahui seberapa besar perubahan penggunaan ECU Programmable di setiap perlakuan terhadap emisi gas buang yang dihasilkan oleh objek penelitian. Jenis penelitian ini adalah penelitian eksperimen. Objek penelitian ini adalah sepeda motor FI. Kadar CO dan HC terendah yang dihasilkan sepeda motor FI dengan penggunaan ECU Programmable diperoleh pada perlakuan saat pengapian 7°BTDC dan saat penginjeksian 350°ATDC menggunakan bahan bakar Gasohol E30. Kadar CO2 terendah diperoleh pada perlakuan saat pengapian 3°BTDC dan saat penginjeksian 350°ATDC menggunakan bahan bakar Pertamax Turbo, dimana hasil yang diperoleh menunjukan perubahan yang signifikan setelah melalui uji banding menggunakan uji T dengan taraf signifikan 5%.
This study discusses changes in the value of CO, CO2 and HC levels of exhaust emission on FI Motorcycle with the use ECU Programmable (4 variation of ignition timing and injector timing) and use 3 variations fuel in every treatment. The purpose of this study was to determine how much influence the use ECU Programmable and variation of fuel on exhaust emissions produced by the research object. This type of research is experimental research. The object of this research is the FI Motorcycle. The lowest CO and HC level produced by FI Motorcycle with the use of a Programmable ECU is obtained in the treatment at ignition timing of 7°BTDC and injector timing 350°ATDC using Gasohol E30 fuel, while the lowest CO2 level is obtained at the ignition timing treatment of 3°BTDC and when injector timing 350°ATDC uses Pertamax Turbo fuel, where the results obtained show significant changes after going through a comparative test using the T test with a significant level of 5%.
Hebrews Articulating Hypostatic Union with Christ
Authors:   ECWA Theological Seminary, Igbaja-Nigeriia, Odeoye Moses Adeleke
Published: August 2023

Hypostatic is derived from the original language of Scripture (Heb. 1:3) which brought the essential person of Jesus in his human and divine natures. Hebrews describes Jesus as superior to all other beings and all other claims. The doctrine of the hypostatic union teaches that our Lord’s divine nature and His human nature were united forever. He is different from the rest of humanity in that He is God and sinless and his unique theanthropic person of the universe. Despite the various opposing objections that attempt to criticize or disprove Jesus Christ’s two natures (divine and human) his obedience to God’s will even to the point of death shows Jesus’ divinity and humanity working together in perfect harmony. The basic idea that Christ is hypostatically communicating with both divine and human energies is also experienced by believers when their humanity is energized by the Holy Spirit and able to speak to God. In conclusion, the explanation of the anthropic unity of the person of Jesus Christ is quite clear that Jesus has both a divine will and a human will. The union of Christ’s divine and human natures are related to His acts as an incarnate person through His experience as a result of his person of Christ.
The Impact of Covid-19 on The Understanding and Preceiving of The Eucharist in The Indonesian Catholic Church
Authors:   Universitas Sanata Dharma Yogyakarta, Martasudjita Emanuel Pranawa Dhatu , Subali Yohanes ,   Universitas Sanata Dharma Yogyakarta, Sasmito Paulus Erwin
Published: August 2023

Covid-19 has changed the order of people’s lives in society all over the world, this also includes the Catholic Church’s order of living. One of the effects that Catholics feel, be that those living in cities or the outskirts is the initiating of online Eucharist masses. As experienced by the Catholic Church all over the world, the Catholic Church in Indonesia experiences inevitable adaptations in regard to applying both online and offline masses. This article is a result of research regarding the understanding and perceiving of the Catholics towards online and offline masses during the times of the Covid-19 pandemic in one of the provinces in the Republic of Indonesia, which includes both urban and rural areas. This research utilizes a mixed method namely quantitative and qualitative through theological, and liturgical approaches. The result of the research shows that generally Catholics still comprehend and perceive offline Masses as something important, but several people are beginning to get used to online Masses which causes inclinations towards perceiving both online and offline Masses as two sides of the same coin.
Tryptophan catabolites and predicted gut flora enzyme-encoding genes
Authors: Shatova OP , Gaponov AM , Grigoryeva TV , Vasilyev IYu , Stoletova LS , Makarov VV , Yudin SM , Roumiantsev SA , Shestopalov AV
Published: August 2023

The signaling role of tryptophan and its catabolites is well known. However, their effects on the potential microbiota metabolic activity is still poorly understood. The study was aimed to assess concordance between changes in the predicted gut microbiome enzyme-encoding gene abundance and the tryptophan catabolites. The study involved 109 healthy volunteers and 114 obese patients. Quantification of tryptophan catabolites in the feces was performed by HPLC. Bacterial DNA was extracted from fecal samples, and the 16S rRNA gene V3-V4 region was sequenced. Primary processing of the sequencing data was performed using the QIIME v.1.9.1 tool. The alleged metabolic role of microbiota members was explored via reconstruction of unobservable states using PICRUSt. The maximum number of significant correlations between the unobservable states and the predicted gut microbiome enzyme-encoding gene abundance in obese individuals was reported for indole-3-lactate. A significant correlation between indole-3-lactate and the abundance of genes encoding the enzymes involved in metabolism of fructose, amino sugars, nucleotides, amino acids, polyamines, and sulfosaccharides was revealed. It has been found that obese patients show a threefold increase in the indole-3lactate-producing microbiota. It has been shown that in obese individuals microbial population of the intestine is represented by the totally different genera and species of microorganisms. It is concluded that indole-3-lactate has a significant effect on the predicted gut microbiome enzyme-encoding gene abundance in obese patients.
Katabolity triptofana i geny fermentov mikrobioma kishechnika
Authors: Шатова О. П. , Гапонов А. М. , Григорьева Т. В. , Васильев И. Ю. , Столетова Л. С. , Макаров В. В. , Юдин С. М. , Румянцев С. А. , Шестопалов А. В.
Published: August 2023

Obshcheizvestna signal'naya rol' triptofana i ego katabolitov. Odnako do sih por ne izucheno ih vliyanie na potencial'nuyu metabolicheskuyu aktivnost' mikrobioty. Cel'yu issledovaniya bylo provesti analiz soglasovannosti izmenenij prognosticheskoj predstavlennosti genov fermentov mikrobioma kishechnika i katabolitov triptofana. V issledovanii prinyali uchastie 109 zdorovyh dobrovol'cev i 114 bol'nyh s ozhireniem. Kolichestvennyj analiz katabolitov obmena triptofana v kale provodili metodom VEZHKH. Iz obrazcov fekalij vydelyali bakterial'nuyu DNK i provodili sekvenirovanie (V3-V4 regiona) gena 16S rRNK. Pervichnuyu obrabotku dannyh sekvenirovaniya osushchestvlyali v programme «QIIME v.1.9.1». Analiz predpolozhitel'noj metabolicheskoj roli uchastnikov mikrobioty provodili putem rekonstrukcii nenablyudaemyh sostoyanij pri pomoshchi PICRUSt. Maksimal'noe kolichestvo statisticheski znachimyh vzaimosvyazej mezhdu katabolitami triptofana i prognosticheskoj predstavlennost'yu genov fermentov mikrobioma u lic s ozhireniem bylo ustanovleno dlya indol-3-laktata. Pokazana statisticheski znachimaya vzaimosvyaz' indol-3-laktata i predstavlennosti genov fermentov obmena fruktozy, aminosaharov, nukleotidov, aminokislot, poliaminov i sul'fosaharov. Ustanovleno, chto u bol'nyh ozhireniem proiskhodit trekhkratnoe uvelichenie indol-3-laktat-produciruyushchej mikrobioty. Pokazano, chto mikrobioticheskaya populyaciya kishechnika predstavlena sovershenno drugimi rodami i vidami mikroorganizmov u lic, imeyushchih ozhirenie. Sdelan vyvod, chto pri ozhirenii indol-3-laktat znachimo vliyaet na prognosticheskuyu predstavlennost' genov fermentov mikrobioma kishechnika.
Understanding Workplace Spirituality in Health Care Systems: Practice and challenges
Authors: Soni Harshita , Soni Chitra , Singh Brijesh
Published: August 2023

Purpose of the Study: The purpose of this paper is to make an enquiry into work place spirituality in health care systems. Based on a theoretical study of spirituality and its growing importance in health care systems; workplace spirituality is discussed with doctors and elements of spirituality which are applied in treating patients are identified. The study has also explored the individual level and system level challenges while practicing spirituality through the identified elements in the health care systems.
Methodology adopted: This is an inductive form of research which involved enquiry into the existing literature of spirituality and further records the focused discussions of doctors for capturing the idea of spirituality in health care systems, identification of elements of spirituality and implementation challenges of spiritual elements in health care systems.
Findings:  The idea of spirituality in healthcare systems includes the trust and belief in supreme power, peace of mind, spiritual care and identifying spirituality as an asset. Gratitude and prayers, counseling, inclusion of the yogic techniques and investment of self in the work are identified as elements of spirituality in healthcare systems. Analysis of data also implied challenges in implementation of spirituality in health care systems.
Practical implications: The findings of the study have identified the elements of spirituality in health care systems not addressed in the previous research. The present study suggests to consider the emotional labor and stress of the doctors developed in the treatment process as the role of doctors is crucial in maintaining the integral health of patients. The implementation challenges of spiritual practices in health care systems are also discussed.
Konsep Penguasaan Negara Atas Pemanfaatan Energi Terbarukan Di Laut Indonesia
Authors: Br Purba Marlina
Published: August 2023

The concept of sovereignty is drawing attention if juxtaposed with the phrase “as big as for the people prosperity”. Therefore the prosperity is for all of the Indonesian people without any exception. What is to be mandated to the country to be sovereignty had and will be used as optimal as possible. If it was not done by the country yet, therefore the phrase “as big as for the people prosperity” is not to be done. This writing is a conceptual article. The analysis mind of economy about the law from utilitarianism Jeremy Betham.
Applying the Resource Dependence Theory to Enhance Supply Chain Management of Small and Medium Scale Enterprises (SMEs) in the Context of Covid-19
Authors: Kulkarni Praveen M , Nayak Gurudutt , P Arun Kumar
Published: August 2023

The Covid-19 pandemic had deeply affected supply chain management across industries, necessitating firms to redefine their strategies to reduce the risk and imbalance caused by the disruption. The study highlights how external risk factors have influenced the internal and organizational factors of the small and medium enterprises (SMEs) in dealing with their supply chain disruptions. We applied the resource dependence theory to illustrate this aspect and also to understand the factors that impact supply chain management. The study applied the interpretive structural modelling (ISM) methodology and Cross Impact Matrix Multiplication Applied to Classification (MICMAC) methodology to understand the inter-dependence relationship between these factors of risk in supply chain management during Covid-19. Our study was specific to the ongoing COVID 19 pandemic as the external factor disrupting supply chains and impacting a firm’s internal and organizational factors in dealing with the impact. Our results showed that external factors deeply influence the internal factors governing supply chain management, which in turn, impact firm performance. Keywords: supply chain management, resource dependency theory, covid-19, small and medium enterprises, decision making
Development of early detection of low-birth-weight instrument based on maternal risk factors: A mixed-methods study
Authors: Utami Sri , Susilaningrum Rekawati , Nursalam Nursalam , Zulaecha Erna Siti , Rahayu Sri
Published: August 2023

Background: Babies born with low birth weight (LBW) are at a higher risk of experiencing health problems. The absence of quick and reliable instruments to detect LBW conditions can significantly impact the growth and development of newborns.
Purpose: This study aims to develop an instrument to detect the incidence of LBW based on mother’s risk factor.
Methods: In this study, mixed-methods research was conducted,   consisting of qualitative and quantitative stages. A total of 20 participants participated in Focus Group Discussions (FGDs) during the qualitative stage, and 321 respondents took part in the quantitative stage. During the qualitative stage, the process of labeling, synthesizing significant codes, and theoretical integration was carried out. Furthermore, at the quantitative stage, the calculation of the cut-off point using receiver operating characteristic (ROC) analysis was performed.
Result: Four indicators were added in newly developed instrument; there are currently ten indicators based on results of our FGD with the experts (OR/score: 74.395/10, 15.557/2, 13.877/2, 9.952/2, 7.203/1, 2.756/1, 2.532/1, 1.280/1, 1.268/1, and 1.163/1). Instrument was tested on 321 samples; it was able to detect 111 (88.1%) cases from a total 123 (38.3%) cases of LBW (p=0.000). Cut-off point determination  used Receiver Operating Characteristic (ROC) curve; any score greater than 3 was predicted with LBW incidence (AUC=0.952, 95% CI 0.923-0.973).
Conclusions: LBW could be predicted by our newly developed instrument. These finding could help  health workers or policy makers to reduce the LBW incidence by early detection. Further study is needed to determine the ideal screening time to maximize the usage of this instrument.
Voces del Islam de hoy
Authors: Ruiz Figueroa Manuel
Published: August 2023

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Assessing Persistence in Spatial Clustering of Disease, with an Application to Drug Related Deaths in Scottish Neighbourhoods
Authors: Congdon Peter Douglas
Published: August 2023

Background: The upward trend in drug related deaths in some countries is a major public health concern. Regarding geographic location within countries, many studies report spatial clustering in drug related deaths. We consider drug related deaths in Scottish small areas, and investigate probabilities that clusters of adjacent neighbourhoods have elevated risk. We focus especially on assessing persistence in spatial clustering, relevant to prioritising area based interventions. We assess impacts of area risk factors on drug deaths, finding a strong link to poverty, and a clear overlap between drug death clustering and spatial poverty clustering. 

Methods: We analyse drug related deaths in 1279 Scotland neighbourhoods over two periods, 2009-13 and 2014- 18, during which drug related mortality in Scotland has more than doubled. A fully Bayesian approach is used to identify zones with high mortality risk in both a neighbourhood and its spatial lag (“high-high” clusters), and extended to identify recurring high risk clustering over more than one period. Estimation of mortality risks, and of cluster probabilities through periods, is developed in conjunction with a regression model including area risk factors such as deprivation. 

Results: Persistent clustering is concentrated in major urban centres, for example, Glasgow and Dundee. Deprivation is the paramount observed risk factor underlying elevated mortality risk, and persistent clustering in drug related mortality shows strong overlaps with poverty clustering. Social fragmentation modifies the paramount influence of poverty on drug mortality risk. 

Conclusion: Cluster persistence is a central feature in small area variability in drug related death risk in Scotland intermediate zones, especially in some urban areas.
Knowledge, acceptance and willingness to pay for Dengue vaccine in Yogyakarta and Jakarta
Authors: Supadmi Woro , Perwitasari Dyah A , Abdulah Rizky , Suwantika Auliya Abdurrohim
Published: August 2023

Despite the fact that Dengue Hemorrhagic Fever (DHF) is one of diseases with the highest incidence rate in Indonesia, its prevention strategies remain ineffective. One of the most cost-effective strategies to prevent DHF is through vaccination. This study aimed to investigate correlations between the knowledge of DHF, the behavior of DHF prevention and the knowledge of vaccine with the acceptance of dengue vaccine and willingness-to-pay (WTP) of dengue vaccine in Yogyakarta and Jakarta, Indonesia. A cross-sectional study was conducted by collecting data from people visiting primary healthcare centers (PHCs) through a valid and reliable questionnaire. A purposive sampling was applied, which resulted in 838 respondents among PHCs in Yogyakarta (two selected districts: Bantul and Kulon Progo) and Jakarta (two selected districts: West Jakarta and Central Jakarta). The result showed that the percentage of respondents who had good knowledge of vaccine was estimated to be 67-77% in all districts. The percentage of respondent who had good acceptance of vaccine was estimated to be 68-81%. WTP of dengue vaccine among respondents was estimated to be IDR 10,000-50,000. The result showed that the knowledge of DHF was significantly correlated (p<0.05) with the acceptance of dengue vaccine in districts of West Jakarta, Bantul and Kulon Progo. In particular, the behavior of DHF prevention and the knowledge of dengue vaccine were significantly correlated (p<0.05) with the acceptance of dengue vaccine in all districts. Additionally, the knowledge and acceptance of vaccine were significantly correlated (p<0.05) with WTP in West Jakarta only. It can be concluded that correlation among variables in all districts are not the same. Hence, specific approach is required to be applied in each district.
Investigation of diagnostic value of artificial intelligence systems in the diagnosis of breast cancer based on histopathological images using Meta-MUMS DTA tool
Authors: Sokouti Massoud , Sadeghi Ramin, Ramin , Pashazadeh Saeid , Abadi Saeid Eslami Hasan , Sokouti Mohsen , Ghojazadeh Morteza , Sokouti Babak
Published: August 2023

ORIGINAL ARTICLES Epidemiology Biostatistics and Public Health - 2020, Volume 17, Number 2Investigation of diagnostic value of artificial intelligence systems in the diagnosis of breast cancer based on histopathological images using Meta-MUMS DTA toolInvestigation of diagnostic value of artificialintelligence systems in the diagnosis of breastcancer based on histopathological imagesusing Meta-MUMS DTA toolABSTRACTBackground: Various artificial intelligence systems are available for diagnosing breast cancer based onhistopathological images. Assessing the performance of existing methodologies for breast cancer diagnosis is vital.Methods: The SCOPUS database has been searched for studies up to December 15, 2018. We extracted the data,including "true positive," "true negative," "false positive," and "false negative". The pooled sensitivity, pooled specificity,positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, area under the curve of summary receiveroperating characteristic curve were useful in assessing the diagnostic accuracy. Egger's test, Deeks' funnel plot, SVE(Smoothed Variance regression model based on Egger’s test), SVT (Smoothed Variance regression model based onThompson’s method), and trim and fill methodologies were essential tests for publication bias identification.Results: Three studies with eight approaches from thirty-seven articles were found eligible for further analysis. Asensitivity of 0.95, a specificity of 0.78, a PLR of 7525, an NLR of 0.06, a DOR of 88.15, and an AUC of 0.953showed high significant heterogeneity; however, the reason was not the threshold effect. The publication bias wasdetected by SVE, SVT, and trim and fill analysis.Conclusion: The artificial intelligent (AI) systems play a pivotal role in the diagnosis of breast cancer usinghistopathological cell images and are important decision-makers for pathologists. The analyses revealed that theoverall accuracy of AI systems is promising for breast cancer; however, the pooled specificity is lower than pooledsensitivity. Moreover, the approval of the results awaits conducting randomized clinical trials with sufficient data
Microplastics as an emerging threat to human health: Challenges and advancements in their detection
Authors: Singh Bibhawari , Srivastava Geetima , Kala Deepak , Gill Maheepinder , Kaushal Ankur , Gupta Shagun
Published: August 2023

Microplastic pollution has emerged as a significant environmental concern, with potential direct and indirect impacts on ecosystems. Microplastics are pervasive, found in water, food, and even the air we breathe. While their influence on human health is still unclear, microplastics are known to possess endocrine-disrupting properties and can accumulate persistent organic pollutants. Accurate measurement and categorization of microplastics are crucial to understanding their prevalence and impact on contamination. Fortunately, there are several methods available, such as visual analysis, fluorescence techniques, vibrational spectroscopy, and electron microscopy, that offer optimal accuracy in detecting and quantifying microplastics. The increasing presence of microplastics in the food chain has prompted global research efforts to assess potential risks to human health. However, despite ongoing advancements, challenges remain in standardizing analytical procedures and developing methods capable of detecting microplastics as small as nanometers. Visual classification-based methods, though limited in detecting smaller microplastics, show promise for improvement through integration with advanced technologies. This study primarily focuses on microplastic sampling strategies, detection methods, and their respective advantages and disadvantages, shedding light on the advancements and challenges in the field.
Visualizing Digital Communities of Practice
Authors: Soria-Martinez Veronica , Olson Brad , Grodoski Chris , Fitzpatrick Jennifer , Ossey Ann
Published: August 2023

In 2021, forty art, design, and media educators throughout a midwestern state in the United States critically examined their lessons through the lenses of social-emotional learning (SEL), standards-based assessment, research-informed practice, and culturally responsive instruction. During the program, teacher-learners recorded their reflections, which are condensed in a presentation-as-art-installation, highlighting dialogic self-reflection in a community of practice. In the video, originally conceived as a 2-channel installation, teachers discuss SEL; equity, diversity, and inclusion; research-informed practice; and standards-based grading, looking at the camera by themselves and reflecting on their daily practice as they incorporate new learning into their teaching. The text discusses how these transformative conversations took place, the necessary conditions for dialogic self-reflection in a community of practice, their impact on their professional practice, and sharing classroom experiences.
Knock knee deformity and body mass index among the male school students of 9 to 13 years old of chandigarh, India
Authors: Choudhary Anurag , Singh Parminder , Singh Mandeep , Dhillon Kanwar Mandeep Singh
Published: August 2023

Study aim: To study knock knee deformity and the body mass index among male school students of Chandigarh, India. The study also intended to evaluate the association of knock knee deformity with BMI.

Material and method: In total, 900 school students were selected, and out of these 300 each were from private, government model and government schools in slum areas. Convenient sampling was employed. The age of the subjects ranged from 9 to 13 years. Height, weight, BMI and intermalleolar distance of selected subjects were assessed. Descriptive statistics, ANOVA and correlation were employed.

Results: The highest percentages of obese (11.3%) and overweight (15.3%) students were found in the private schools. The highest percentages of severe knock knee deformity (10.7%) were found in the students of the private schools, whereas 16.7% of students in the government model schools had moderate knock knee deformity. Height, weight and BMI were significantly correlated with knock knee deformity.

Conclusion: Body weight among the school students might be associated with the school type, as the problem of obesity and underweight was pervasive in private and government schools. Knock knee deformity was related to the school type and body weight status.
The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome
Authors: Zenoaga-Barbăroșie C , Berca L , Vassu-Dimov T , Toma M , Nica MI , Alexiu-Toma OA , Ciornei C , Albu A , Nica S , Nistor C , Nica R
Published: August 2023

Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are diseases caused by the interaction of genetic and non-genetic factors. Therefore, the aim of our study was to investigate the association between six common genetic polymorphisms and T2DM and MetS in males. A total of 120 T2DM, 75 MetS, and 120 healthy controls (HC) were included in the study. ACE ID, eNOS 4a/b, ATR1 A1166C, OXTR (A>G), SOD1 +35A/C, CAT-21A/T gene polymorphisms were genotyped by PCR or PCR-RFLP techniques. T2DM was diagnosed at an earlier age compared to MetS (54 vs 55 years old, p=0.0003) and the difference was greater in carriers of the OXTR G allele (54 vs 56 years old, p=0.0002) or both OXTR G and eNOS b alleles (54 vs 56, p=0.00016). The SOD1 AA genotype (O.R.=0.11, p=0.0006) and the presence of both ACE I and OXTR1 A (O.R.=0.39, p=0.0005) alleles revealed to be protective for T2DM. SOD1 AA and AC genotypes were protective factors for triglyceride (p=0.0002 and p=0.0005, respectively) and HDL cholesterol (p=0.0002 and p=0.0004, respectively) levels in T2DM patients. ACE DD was identified more frequently in hypertensive T2DM patients (O.R.=3.77, p=0.0005) and in those who reported drinking alcohol (p=0.0001) comparing to HC and T2DM patients who did not drink alcohol, respectively. We observed that T2DM patients who reported drinking alcohol had an increased frequency of ACE DD and eNOS bb (p<0.0001), or ACE DD and OXTR G (p<0.0001) compared to non-drinkers. No gene polymorphisms were associated with MetS.
Association of rs35006907 Polymorphism with Risk of Dilated Cardiomyopathy in Han Chinese Population
Authors: Yang C , Chen F , Li Sh , Zeng X , Wang Sh , Lan J
Published: August 2023

Background

Several investigations have demonstrated the association of MTSS1 with left ventricular (LV) structure and function. A recently published study has even revealed that rs35006907 was associated with both MTSS1 expression and the risk of dilated cardiomyopathy (DCM).

Objective

Our study intended to investigate the relationship between rs35006907 and the risk of DCM in the Han Chinese population.

Methods

A total of 529 DCM and 600 healthy controls were recruited. We conducted genotyping for rs35006907 in all participants. Gene association studies were performed to assess the association between rs35006907 and the risk of DCM. A series of functional assays including western blot, realtime PCR and firefly luciferase reporter gene assays were conducted to illuminate the underlying mechanism.

Results

We found that rs35006907-A allele was significantly associated with reduced risk of DCM in additive (p= 0.004; OR=0.78; 95% CI=0.66–0.93) and recessive models (p= 0.0005; OR=0.56; 95%CI=0.41–0.78) when compared with the rs35006907-C allele. There were significant differences in the left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) between rs35006907-CC/AC and AA genotypes. Furthermore, the variant rs35006907-A allele presented lower reporter gene activity, reduced mRNA and protein expression levels when compared with the C allele.

Conclusions

Our findings demonstrated that rs35006907-C allele increased the risk of DCM in Han Chinese population. Besides, rs35006907-C displayed higher reporter gene activity and increased MTSS1 expression in human samples.
Purchase Intent and Product Appeal of Velo Nicotine Pouches Among Current Tobacco Users and Nonusers of Tobacco
Authors: Freeland Robert E. , Battista Deena R. , Polster Michael , Chae Robyn , Dianno Nicole , Frost-Pineda Kimberly
Published: August 2023

Background and objectives

Oral nicotine pouches is a rapidly growing product category that potentially offers less risk than combustible tobacco products. Nicotine pouches may provide harm reduction for smokers because they contain no tobacco and have reduced harmful constituents compared to traditional tobacco product categories. Any potential public health benefit must weigh the likelihood that current tobacco users will switch to the lower-risk product against the likelihood that nonusers will start using tobacco products. To our knowledge, no existing studies provide population-level estimates of purchase intent or product appeal across tobacco user groups or how product characteristics might affect those variables.

Methods

This paper presents population-level estimates of purchase intent and product appeal for multiple Velo nicotine pouch products (including different flavors, nicotine strengths, format, and packaging) among five adult tobacco user groups (current established cigarette smokers, current established non-cigarette tobacco users, current tobacco experimenters, former tobacco users, and never ever tobacco users). Over 49,000 respondents were surveyed across twelve analytic samples.

Results

Results for the pooled sample as well as for each individual sample were remarkably consistent for every product. Ratings of purchase intent and appeal are higher for current tobacco users (current established cigarette smokers, current established non-cigarette tobacco users, and current tobacco experimenters) than for former and never ever tobacco users.

Conclusions and scientific significance

Variation in product characteristics had little or no effect on purchase intent or appeal ratings across tobacco user groups, suggesting that product characteristics do not materially affect public health.
Motivation and Engagement as a Predictor of Students’ Science Achievement Satisfaction of Malaysian of Secondary School Students
Authors: Mai Mohammed Y. M. , Yusuf Muhammed , Saleh Maria
Published: August 2023

Psychologists consider student engagement as a primary pathway by which motivational processes contribute to students’ learning and development (Connell & Wellborn, 1991). Academically engaged students self-regulate their learning, make plans for upcoming tasks, and persist when encountering obstacles and challenges. The present study intends to analyses the relationship between students’ motivation and engagement and their academic satisfaction and test the effect of some variables (gender, class) on that relation. To accomplish these purposes, this study intends to investigate Malaysian primary school students’ motivation, engagement and achievement satisfaction as predictors of achievement satisfaction in science and test the effect of some variables (gender, grade) on that relation. The students - 460 students (43% male, 57% female) of secondary school- responded to the Self-Developed Academic Satisfaction Questionnaire, Students’ Engagement Questionnaire and Science Motivation Questionnaire. All the questionnaires are valid and reliable according to the Cronbach’s Alpha value. A Multiple linear regression analysis has been used to predict the achievement satisfaction of Science based on the level of students’ motivation and level of engagement in Science classroom. The findings showed that students have a good level of motivation, engagement and achievement satisfaction. Even though students’ motivation is significantly predicted students’ achievement, but neither students’ engagement nor achievement satisfaction are a significant predictor of students’ achievement.
Efficacy and safety of SGLT2 inhibitors in individuals with type 1 diabetes under continuous subcutaneous insulin infusion: a real-world study
Authors: Silva Vania Benido , Fonseca Liliana , Duarte Diana Borges , Puga Francisca Marques , Assuncao Guilherme , Garrido Susana , Teixeira Sofia , Vilaverde Joana , Cardoso Maria Helena
Published: August 2023

Objective. Adjuvant therapy with sodium-glucose cotransport 2 inhibitors (SGLT2i) in type 1 diabetes (T1D) is associated with an improvement in glycemic control, but increases the risk of diabetic ketoacidosis (DKA). However, real-life studies in individuals with T1D under continuous subcutaneous insulin infusion (CSII) are still scarce. We present the first real-life study performed in patients with T1D exclusively treated with CSII. The aim of the present study was to assess the metabolic impact and safety of SGLT2i in T1D individuals under CSII.

Methods. Retrospective study includes 34 T1D adult individuals under CSII, who started SGLT2i until 30th June 2021. Data regarding the glycemic control and acute diabetes complications at the moment of introduction of SGLT2i and after 3, 6, and 12 months of use were collected.

Results. Twenty-three individuals were included. Comparing with the moment of SGLT2i introduction after 3, 6, and 12 months of use, there was a statistically significant increase of time in range (TIR) (∆T3M=12.8%; ∆T6M=11.5%; ∆T12M=11.1%), and a decrease in time above range (∆T3M=13.6%; ∆T6M=11.9%; ∆T12M=10.5%). There were no significant differences in time below the range. Mean glucose and mean glucose management indicator significantly reduced in the 3 evaluated moments. A significant reduction in median weight was also observed (∆T6M=2 kg; ∆T12M=4.5 kg). Two patients (8.7%) developed mild euglycemic DKA during SGLT2i treatment, both were women and had body mass index (BMI) <27 kg/m2. One of them had a total daily insulin dose (TDDI) reduction of 26.9% after 3 months of use.

Conclusions. The use of SGLT2i, as an adjuvant treatment in T1D individuals under CSII, was associated with a significant increase of TIR without increasing time in hypoglycemia. It also had a weight benefit. Careful use in selected participants is necessary to reduce the occurrence of DKA.
Cultural Impact and an Intimate Partner aggression in African Societies: A comparison of Rwanda and South Sudan
Authors: Ndoromo Owen , Banyanga Jean d’Amour
Published: August 2023

The study investigated therole of cultural impact on South Sudanese and Rwandan women who nowadays reside in the diaspora in Finland and Belgium. It explores the cultural violence against women before and after the 1994 Rwandan genocide against the Tutsis, and after the independency of South Sudan. This argument is presented through an analysis of existing literature and documents; and through interviews with 341 respondents (166 men and 175 women) belonging to the Rwandan diaspora in Belgium and in Finland; and 420 participants (302 females and 118 males) married, divorced, single mothers in South Sudan. The results show that women and girls in South Sudan continue to be at risk of violence from cultural impact more than Rwandan women. Poverty, education, and insecurity play a huge role in promoting aggression against South Sudanese women.
Immune Reconstitution in Late-Presenting HIV-Positive a Case with Idiopathic Liver Cirrhosis and Ischemic Brain Stroke
Authors: Pakov Ivaylo N.
Published: August 2023

A patient diagnosed with late-presenting HIV infection [CD4 count 86 cells/mm3, viral load (VL) 95 000 copies RNA/mL], treated with DRV/c 800/150 mg (Rezolsta®) and TDF/FTC 200/245 mg, was hospitalized with ischemic brain stroke, confirmed by CT scan and MRI. Motor functions quickly recovered, but nausea, abdominal heaviness, ascites, and hepatosplenomegaly appeared. Laboratory investigations revealed anaemia, thrombocytopenia, normal transaminases, increased GGT and negative serological tests for HBV and HCV and she was diagnosed with Gastroenterologists diagnosed liver cirrhosis. After 20 days of hospital treatment, the patient recovered from the stroke and ascites but with persisting anaemia and thrombocytopenia. Liver cirrhosis had been confirmed, and relevant treatment had been administered. Six months later, an MRI of the brain revealed an improved image. Follow-up showed stabilized somatic and neurologic status, improved laboratory parameters, stable T-helper count and undetectable viral load (VL). ART regimen continued with Raltegravir 400 mg (Isentress®) 2×1 tablet/24 h, TDF/FTC 200/245 mg 1 tablet/24 h. Three months later, the patient continued her treatment continued abroad. The increased access to precise diagnosis and treatment with improved adherence has transformed the HIV-infection into a manageable chronic health condition, even in complicated cases.
COVID-19: A Possible Cause of Spontaneous Pneumoperitoneum
Authors: Ramos Patrícia Varela , Oliveira Ana Maria , Simas Ângela , Rocha Vera Cruz Margarida
Published: August 2023

Introduction

Pneumoperitoneum is the presence of air within the peritoneal cavity and is mostly caused by organ rupture. Spontaneous pneumoperitoneum accounts 5% to 15% of the cases and occurs in the absence of organ damage. The pulmonary origin of pneumoperitoneum is unusual, and probably associated with mechanical ventilation and alveolar leak. In patients with coronavirus disease 2019 (COVID-19) there are some reports of air leak, like pneumothorax, pneumomediastinum, pneumoperitoneum, and subcutaneous emphysema.

Case presentation

We present the case of a 70-year-old man with COVID-19 pneumonia admitted to the Intensive Care Unit (ICU). Since admission he was on Non-Invasive Ventilation (NIV), without improvement, needing Invasive Mechanical Ventilation (IMV) due to severe respiratory failure. Five days after IMV despite protective lung ventilation, massive spontaneous subcutaneous emphysema, pneumomediastinum and pneumoperitoneum were diagnosed. Besides initial conservative management 12 hours later, the patient developed abdominal compartment syndrome requiring percutaneous needle decompression.

Conclusions

Pneumoperitoneum can be considered a rare complication of COVID-19 pneumonia and its management, resulting not only from the viral pulmonary but also from secondary causes. Conservative management should be usually enough. However, in the presence of abdominal compartment syndrome prompt recognition and treatment are crucial and eventually lifesaving.
Thermal regime of the Danube Delta and the adjacent lakes
Authors: Vyshnevskyi Viktor , Shevchuk Serhii
Published: August 2023

The Danube Delta is a unique natural object influenced by natural and human factors. According to the available observation and remote sensing data, the features of the water temperature in the Danube Delta, as well as in nearby lakes and the adjacent area of the Black Sea, have been determined. The water temperature in the Danube River was found to be much higher than the air temperature, especially in autumn. Generally, it is also higher than in nearby lakes and the adjacent part of the Black Sea. During 1961–2021 the mean annual water temperature in the Danube Delta increased significantly, especially during the last three decades. It has been determined that water temperature is affected not only by air temperature, but also by water discharge and wind. With a large water discharge the mixing of water is intensified and it causes the decrease of surface water temperature during the main part of the year with the exception of the coldest months. The greatest impact of water discharge on the water temperature is observed in June. The cool breeze in summer months also has some effect on the surface water temperature of the river near the seashore. The results show the potential of remote sensing to track the changes of water temperature along the river and to identify the shallow sections.