bluuebunny/crossref_metadata_2025 huggingface dataset:
Allostatic Load in Perimenopausal Women With Migraine
Authors: Alebna Pamela , Maleki Nasim
Published: April 2021

Objective: There is very limited data on women with migraine disease as they age and transition to menopause. Despite evidence for the increased burden of the disease during this transition, there is no data on the association between migraine and allostatic load as a marker of cumulative biological risk. We aimed to determine whether women with migraine suffer from higher levels of allostatic load during perimenopausal transition.

Methods: A total of 2,105 perimenopausal women from the first wave of the Study of Women's Health Across the Nation (SWAN) were included in this study. Allostatic Load (AL) score was estimated for each participant from the measurements of: systolic and diastolic blood pressure, C-reactive protein level, high-density lipoprotein cholesterol level, total cholesterol level, waist-to-hip ratio, fasting serum glucose, triglycerides, and dehydroepiandrosterone levels.

Results: Of the 2,105 participants included in the study, there were 369 migraineurs and 1,730 controls. Migraineurs had 63% higher odds of increased load score (odds ratio 1.63; 95% confidence interval, 1.17–2.29). Compared to controls, migraineurs were more likely to experience sleep problems in the univariate analysis, however despite the high burden of sleep problems, there were no significant associations between allostatic load and sleep disturbances in perimenopausal women with migraine after controlling for other factors.

Conclusion: This is the first study to systematically and quantitatively examine allostatic load in migraine patients. The findings establish that migraineurs are more likely to experience higher allostatic load than their non-migraine counterparts during perimenopausal transition. The findings encourage new lines of investigation for lowering the burden of the disease through interventions that modify the levels of allostatic load biomarkers examined in this study.
Neural Mechanisms of Observational Learning: A Neural Working Model
Authors: Kang Weixi , Pineda Hernández Sònia , Mei Jie
Published: April 2021

Humans and some animal species are able to learn stimulus-response (S-R) associations by observing others' behavior. It saves energy and time and avoids the danger of trying the wrong actions. Observational learning (OL) depends on the capability of mapping the actions of others into our own behaviors, processing outcomes, and combining this knowledge to serve our goals. Observational learning plays a central role in the learning of social skills, cultural knowledge, and tool use. Thus, it is one of the fundamental processes in which infants learn about and from adults (Byrne and Russon, 1998). In this paper, we review current methodological approaches employed in observational learning research. We highlight the important role of the prefrontal cortex and cognitive flexibility to support this learning process, develop a new neural working model of observational learning, illustrate how imitation relates to observational learning, and provide directions for future research.
Tapping Force Encodes Metrical Aspects of Rhythm
Authors: Benedetto Alessandro , Baud-Bovy Gabriel
Published: April 2021

Humans possess the ability to extract highly organized perceptual structures from sequences of temporal stimuli. For instance, we can organize specific rhythmical patterns into hierarchical, or metrical, systems. Despite the evidence of a fundamental influence of the motor system in achieving this skill, few studies have attempted to investigate the organization of our motor representation of rhythm. To this aim, we studied—in musicians and non-musicians—the ability to perceive and reproduce different rhythms. In a first experiment participants performed a temporal order-judgment task, for rhythmical sequences presented via auditory or tactile modality. In a second experiment, they were asked to reproduce the same rhythmic sequences, while their tapping force and timing were recorded. We demonstrate that tapping force encodes the metrical aspect of the rhythm, and the strength of the coding correlates with the individual’s perceptual accuracy. We suggest that the similarity between perception and tapping-force organization indicates a common representation of rhythm, shared between the perceptual and motor systems.
PyGeNN: A Python Library for GPU-Enhanced Neural Networks
Authors: Knight James C. , Komissarov Anton , Nowotny Thomas
Published: April 2021

More than half of the Top 10 supercomputing sites worldwide use GPU accelerators and they are becoming ubiquitous in workstations and edge computing devices. GeNN is a C++ library for generating efficient spiking neural network simulation code for GPUs. However, until now, the full flexibility of GeNN could only be harnessed by writing model descriptions and simulation code in C++. Here we present PyGeNN, a Python package which exposes all of GeNN's functionality to Python with minimal overhead. This provides an alternative, arguably more user-friendly, way of using GeNN and allows modelers to use GeNN within the growing Python-based machine learning and computational neuroscience ecosystems. In addition, we demonstrate that, in both Python and C++ GeNN simulations, the overheads of recording spiking data can strongly affect runtimes and show how a new spike recording system can reduce these overheads by up to 10×. Using the new recording system, we demonstrate that by using PyGeNN on a modern GPU, we can simulate a full-scale model of a cortical column faster even than real-time neuromorphic systems. Finally, we show that long simulations of a smaller model with complex stimuli and a custom three-factor learning rule defined in PyGeNN can be simulated almost two orders of magnitude faster than real-time.
Quantitative Optical Coherence Tomography Angiography Detects Retinal Perfusion Changes in Carotid Artery Stenosis
Authors: Pierro Luisa , Arrigo Alessandro , De Crescenzo Michele , Aragona Emanuela , Chiesa Roberto , Castellano Renata , Catenaccio Barbara , Bandello Francesco
Published: April 2021

Background

Carotid artery stenosis (CAS) is a multifaceted disease characterized by possible ocular involvement. Treatment with carotid endarterectomy helps to restore cerebral perfusion, which may prevent ocular and cerebral complications. The main aim was to assess retinal and choroidal vascular perfusion changes before and after endarterectomy in patients affected by CAS.

Methods

The design of the study was prospective and observational, including patients affected by CAS and healthy controls. The follow-up was 3 months. We performed quantitative optical coherence tomography (OCT) angiography (OCTA) analyses of retinal perfusion changes, before and after endarterectomy. The main outcome measures were the quantitative changes of choroidal thickness (CT), retinal nerve fiber layer (RNFL), and ganglion cell layer (GCL); vessel density (VD); and vessel tortuosity (VT) OCTA metrics were also measured.

Results

Sixty eyes of 30 patients affected by CAS and 30 eyes of 30 controls were included. We separately considered the ipsilateral eyes to CAS, the contralateral eyes to CAS, and the healthy eyes. Visual symptoms were absent in all the patients. RNFL and GCL resulted similar between patients and controls (p > 0.05). CT was significantly thinner in ipsilateral eyes than controls (p < 0.01), and it resulted unchanged after surgery (p > 0.05). VD resulted significantly altered only in some plexa of the ipsilateral eyes (p < 0.01), whereas VT disclosed decreased values of the entire retinal vascular network, both in ipsilateral and contralateral eyes (p < 0.05). Endarterectomy was followed by statistically significant improvement of retinal perfusion (p < 0.05).

Conclusion

Optical coherence tomography angiography can noninvasively detect postendarterectomy retinal perfusion improvements in CAS patients with baseline diabetes and hypertension as a systemic risk factor.
Predict Colon Cancer by Pairing Plasma miRNAs: Establishment of a Normalizer-Free, Cross-Platform Model
Authors: Qin Da , Guo Qingdong , Wei Rui , Liu Si , Zhu Shengtao , Zhang Shutian , Min Li
Published: April 2021

Background

Plasma miRNAs are emerging biomarkers for colon cancer (CC) diagnosis. However, the lack of robust internal references largely limits their clinical application. Here we propose a ratio-based, normalizer-free algorithm to quantitate plasma miRNA for CC diagnosis.

Methods

A miRNA-pair matrix was established by pairing differentially expressed miRNAs in the training group from GSE106817. LASSO regression was performed to select variables. To maximize the performance, four algorithms (LASSO regression, random forest, logistic regression, and SVM) were tested for each biomarker combination. Data from GSE106817 and GSE112264 were used for internal and external verification. RT-qPCR data acquired from another cohort were also used for external validation.

Results

After validation through four algorithms, we obtained a 4-miRNA pair model (miR-1246 miR-451a; miR-1246 miR-4514; miR-654-5p miR-575; miR-4299 miR-575) that showed good performance in differentiating CC from normal controls with a maximum AUC of 1.00 in internal verification and 0.93 in external verification. Tissue validation showed a maximum AUC of 0.81. Further external validation using RT-qPCR data exhibited good classifier ability with an AUC of 0.88.

Conclusion

We established a cross-platform prediction model robust against sample-specific disturbance, which is not only well-performed in predicting CC but also promising in the diagnosis of other diseases.
Nivolumab and Hypofractionated Radiotherapy in Patients With Advanced Lung Cancer: ABSCOPAL-1 Clinical Trial
Authors: Ye Hua , Pang Haowen , Shi Xiangxiang , Ren Peirong , Huang Shangke , Yu Hong , Wu Jingbo , Lin Sheng
Published: April 2021

Background

More clinical practice need to be performed to verify the toxicity of the hypofractionated radiotherapy (HFRT) combined with PD-1 blockade in lung cancer. This phase I study aimed to investigate the safety and efficacy of nivolumab combined with HFRT in patients with progressive advanced lung cancer following multiline treatment.

Methods

We enrolled 31 patients with advanced lung cancer pathologically confirmed to have progressive disease and treated with first-line or a higher therapy. Selected lesions were treated using HFRT, and nivolumab was administered within 7 days subsequently. Nivolumab was administered once a month following partial remission. Peripheral blood was collected before and after 1 month of treatment to evaluate relevant cytokines between nivolumab responders and non-responders.

Results

Overall, 23 patients who completed the treatment were evaluated. Of them, 9 and 14 patients underwent hypofractionated brachytherapy with 30 Gy in a single fraction via percutaneous interstitial implantation of (192)Ir and 40–50 Gy in 5 fractions via stereotactic body radiation therapy, respectively. The median follow-up period was 11 months. At the 1-year follow-up, no patient developed grade ≥ 3 pneumonitis. The overall objective response and complete remission rates were 39.13% and 13.04%, respectively. The 1-year overall survival and median progression-free survival were 60.9% and 6 months, respectively. The plasma levels of interleukin IL-6, IL-10, and IL-17A were significantly reduced after treatment in nivolumab responders.

Conclusions

HFRT could increase the responsivity to nivolumab and reduce its administration frequency. This combination treatment is well tolerated with acceptable toxicity and thus merits further trials to validate benefits.

Clinical Trial Registration

http://www.chictr.org.cn/index.aspx, identifier ChiCTR-1900027768.
Reporters of Cancer Stem Cells as a Tool for Drug Discovery
Authors: Mohan Amrutha , Raj R. Reshma , Mohan Gayathri , K. P. Padmaja , Maliekal Tessy Thomas
Published: April 2021

In view of the importance of cancer stem cells (CSCs) in chemoresistance, metastasis and recurrence, the biology of CSCs were explored in detail. Based on that, several modalities were proposed to target them. In spite of the several clinical trials, a successful CSC-targeting drug is yet to be identified. The number of molecules screened and entered for clinical trial for CSC-targeting is comparatively low, compared to other drugs. The bottle neck is the lack of a high-throughput adaptable screening strategy for CSCs. This review is aimed to identify suitable reporters for CSCs that can be used to identify the heterogeneous CSC populations, including quiescent CSCs, proliferative CSCs, drug resistant CSCs and metastatic CSCs. Analysis of the tumor microenvironment regulating CSCs revealed that the factors in CSC-niche activates effector molecules that function as CSC markers, including pluripotency markers, CD133, ABCG2 and ALDH1A1. Among these factors OCT4, SOX2, NANOG, ABCG2 and ALDH1A1 are ideal for making reporters for CSCs. The pluripotency molecules, like OCT4, SOX2 and NANOG, regulate self-renewal, chemoresistance and metastasis. ABCG2 is a known regulator of drug resistance while ALDH1A1 modulates self-renewal, chemoresistance and metastasis. Considering the heterogeneity of CSCs, including a quiescent population and a proliferative population with metastatic ability, we propose the use of a combination of reporters. A dual reporter consisting of a pluripotency marker and a marker like ALDH1A1 will be useful in screening drugs that target CSCs.
Case Report: Primary Extraskeletal Osteosarcoma in the Lung and Pulmonary Artery
Authors: Zhai Duchang , Cai Wu , Fan Guohua , Yang Junlin , Liu Chenchen
Published: April 2021

Extraskeletal osteosarcoma is an uncommon and high-grade soft tissue malignancy. The incidence is even lower when the lung and pulmonary artery are the primary site. The purpose of this report is to present the radiological features of this neoplasm in a 52-year-old man. In our case, contrast-enhanced CT and 3D-CT reconstruction clearly showed the primary lesion and its invasion into surrounding tissues. Although wide local excision of the primary tumor is the treatment of choice, local recurrence and metastasis rates remain high, and this progression can be clearly shown on CT and SPECT/CT examinations.
Targeting Gremlin 1 Prevents Intestinal Fibrosis Progression by Inhibiting the Fatty Acid Oxidation of Fibroblast Cells
Authors: Yang Yang , Zeng Qi-Shan , Zou Min , Zeng Jian , Nie Jiao , Chen DongFeng , Gan Hua-Tian
Published: April 2021

Intestinal fibrosis is a consequence of continuous inflammatory responses that negatively affect the quality of life of patients. By screening altered proteomic profiles of mouse fibrotic colon tissues, we identified that GREM1 was dramatically upregulated in comparison to that in normal tissues. Functional experiments revealed that GREM1 promoted the proliferation and activation of intestinal fibroblast cells by enhancing fatty acid oxidation. Blocking GREM1 prevented the progression of intestinal fibrosis in vivo. Mechanistic research revealed that GREM1 acted as a ligand for VEGFR2 and triggered downstream MAPK signaling. This facilitated the expression of FAO-related genes, consequently enhancing fatty acid oxidation. Taken together, our data indicated that targeting GREM1 could represent a promising therapeutic approach for the treatment of intestinal fibrosis.
Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective
Authors: Liao Shengnan , Yue Wang , Cai Shuning , Tang Quan , Lu Weitong , Huang Lingxiao , Qi Tingting , Liao Jinfeng
Published: April 2021

Cancer is a life-threatening disease, and there is a significant need for novel technologies to treat cancer with an effective outcome and low toxicity. Photothermal therapy (PTT) is a noninvasive therapeutic tool that transports nanomaterials into tumors, absorbing light energy and converting it into heat, thus killing tumor cells. Gold nanorods (GNRs) have attracted widespread attention in recent years due to their unique optical and electronic properties and potential applications in biological imaging, molecular detection, and drug delivery, especially in the PTT of cancer and other diseases. This review summarizes the recent progress in the synthesis methods and surface functionalization of GNRs for PTT. The current major synthetic methods of GNRs and recently improved measures to reduce toxicity, increase yield, and control particle size and shape are first introduced, followed by various surface functionalization approaches to construct a controlled drug release system, increase cell uptake, and improve pharmacokinetics and tumor-targeting effect, thus enhancing the photothermal effect of killing the tumor. Finally, a brief outlook for the future development of GNRs modification and functionalization in PTT is proposed.
Heralded Generation of Vectorially Structured Photons With a High Purity
Authors: Wu Hai-Jun , Yu Bing-Shi , Zhu Zhi-Han , Rosales-Guzmán Carmelo , Zhou Zhi-Yuan , Ding Dong-Sheng , Gao Wei , Shi Bao-Sen
Published: April 2021

Engineering vector spatial modes of photons is an important approach for manipulating high-dimension photonic states in various quantum optical experiments. In this work, we demonstrate the generation of heralded single photons with well-defined vector spatial modes by using a self-stable polarizing interferometer comprising a spatial light modulator. Specifically, it is shown that, by carefully tailoring and compensating the spatial and temporal amplitudes of manipulated photons, one can exactly convert ultrafast single photons into desired spin-orbit states with an extremely high purity. This compact and robust device provides a versatile way for not only the generation, but also the manipulation and characterization of arbitrary photonic spin-orbit states.
Thermodynamics of Many Black Holes
Authors: Gregory Ruth , Lim Zheng Liang , Scoins Andrew
Published: April 2021

We discuss the thermodynamics of an array of collinear black holes which may be accelerating. We prove a general First Law, including variations in the tensions of strings linking and accelerating the black holes. We analyse the implications of the First Law in a number of instructive cases, including that of the C-metric, and relate our findings to the previously obtained thermodynamics of slowly accelerating black holes in anti-de Sitter spacetime. The concept of thermodynamic length is found to be robust and a Christoudoulou-Ruffini formula for the C-metric is shown.
Macrophomina phaseolina: General Characteristics of Pathogenicity and Methods of Control
Authors: Marquez Nathalie , Giachero María L. , Declerck Stéphane , Ducasse Daniel A.
Published: April 2021

Macrophomina phaseolina is a generalist soil-borne fungus present all over the world. It cause diseases such as stem and root rot, charcoal rot and seedling blight. Under high temperatures and low soil moisture, this fungus can cause substantial yield losses in crops such as soybean, sorghum and groundnut. The wide host range and high persistence of M. phaseolina in soil as microsclerotia make disease control challenging. Therefore, understanding the basis of the pathogenicity mechanisms as well as its interactions with host plants is crucial for controlling the pathogen. In this work, we aim to describe the general characteristics and pathogenicity mechanisms of M. phaseolina, as well as the hosts defense response. We also review the current methods and most promising forecoming ones to reach a responsible control of the pathogen, with minimal impacts to the environment and natural resources.
Hazard Perception, Presence, and Simulation Sickness—A Comparison of Desktop and Head-Mounted Display for Driving Simulation
Authors: Malone Sarah , Brünken Roland
Published: April 2021

Driving simulators are becoming increasingly common in driver training and assessment. Since virtual reality is generally regarded as an appropriate environment for measuring risk behavior, simulators are also used to assess hazard perception, which is considered to be one of the most important skills for safe driving. Simulators, which offer challenges that are indeed comparable to driving in real traffic, but at a very low risk of physical injury, have the potential to complement theoretical and practical driver trainings and tests. Although configurations and fidelity differ considerably between driving simulators, studies comparing the impact of their distinct features on driving performance and test validity remain rare. In this context, prior research demonstrated that a wider field of view (three monitors compared to a single monitor) led to earlier speed adjustments in response to potential hazards—especially for experienced drivers. The wider field of view was assumed to cause the drivers to be more present in the virtual world, which in turn provoked more natural scanning of the road and therefore, earlier hazard detection in experienced drivers. Research on spatial presence in other contexts support this assumption. The present experiment investigated whether this effect could be enhanced by an even more immersive presentation technique for driving simulation: a head-mounted display (HMD). Moreover, we studied the interplay between display mode, sense of presence and simulation sickness. Eighty experienced and less experienced drivers completed six simulation-based hazard perception scenarios, which were displayed either via a triple-monitor set-up or an HMD. Results indicate that the experienced drivers showed very similar driving and risk behavior as the inexperienced drivers in both experimental conditions. However, there were significant differences between the two display conditions. The use of an HMD resulted in a clearer and more abrupt speed reduction, more virtual presence, and a higher degree of simulation sickness. However, the interrelation between these three variables could not be conclusively clarified in the present study and thus represents a research aim that could be addressed in future studies.
What Psychological Factors Make Individuals Believe They Are Infected by Coronavirus 2019?
Authors: Daniali Hojjat , Flaten Magne Arve
Published: April 2021

Background: We previously showed, by means of an online-based survey, that the belief of being infected by coronavirus disease 2019 (COVID-19) acted as a nocebo and predicted higher perception of symptoms similar to COVID-19 symptoms. However, there is little known about the psychological mechanisms that give rise to beliefs such as certainty of being infected by COVID-19, and this was investigated in the present study.

Objective: Using the same data from the previous online survey with the same research team, we further investigated whether certainty of being infected by COVID-19 is associated with age, sex, health anxiety, and/or personality traits.

Methods: Respondents (N = 375) filled out an online survey with 57 questions about symptoms similar to COVID-19, certainty of being infected by COVID-19, anxiety, stress, health anxiety, and personality dimensions (based on the five-factor model of personality).

Results: Higher levels of conscientiousness and health anxiety were independently associated with certainty of being infected by COVID-19. The model predicted 29% of the variance in certainty of being infected by COVID-19.

Conclusion: Being conscientious and worried about health issues were associated with the belief of being infected by COVID-19. Such finding may have implications for health care personnel who provide COVID-19 testing or consulting services to general population, as individuals high in these traits may over-report COVID-like symptoms. Theoretically, these findings point to psychological factors that may increase nocebo and possibly placebo effects. Clinically, the findings suggest that individuals high in conscientiousness and health anxiety may be more likely to over-report their bodily experiences.
Mental Health During the First Weeks of the COVID-19 Pandemic in the United States
Authors: Killgore William D. S. , Cloonan Sara A. , Taylor Emily C. , Dailey Natalie S.
Published: April 2021

Background: By March 2020, the World Health Organization declared the COVID-19 crisis as a worldwide pandemic and many local governments instituted stay-at-home orders and closed non-essential businesses. Within the United States, tens of millions of workers lost their jobs and financial security during the first few weeks of the national response, in an attempt to slow the global pandemic. Because of the enormity of the pandemic and its potential impact on mental health, the objective of the present study was to document the prevalence of mental health problems and their association with pandemic-related job loss during the third week of the nationwide shutdown.

Methods: Mental health was assessed via online questionnaires among a representative sample of 1,013 U.S. adults on April 9–10, 2020. Rates of clinically significant mental health outcomes were compared between participants who lost their job as a result of COVID-19 restrictions (17.4%) vs. those who did not (82.6%). Bivariate multiple logistic regression identified factors that were predictive of, and protective against, mental health problems.

Results: The prevalence of clinically significant symptoms was significantly higher than prior population estimates, ranging from 27 to 32% for depression, 30 to 46% for anxiety disorders, 15 to 18% for acute/post-traumatic stress, 25% for insomnia, and 18% for suicidal ideation. Prevalence estimates were 1.5–1.7 times higher for those who reported job loss due to COVID-19 restrictions than those who did not. Mental health problems were predicted by worry over financial instability, insomnia, social isolation, and alcohol consumption, while getting outside more often, perceived social support, and older age were protective against these problems.

Conclusions: During the first 3 weeks of lockdowns/stay-at-home restrictions, mental health problems, including depression, anxiety, insomnia, and acute stress reactions were notably elevated relative to prior population estimates. Job loss related to the nationwide shutdown was particularly associated with poorer mental health. These findings provide a baseline of mental health functioning during the first weeks of the national emergency and lockdown orders in response to COVID-19.
Psychometric Properties of the Exercise Orientation Questionnaire: A Confirmatory Study on Chinese University Students
Authors: Chang Jindong , Yong Liming , Yi Yali , Liu Xiaolei , Song Hanbing , Li Yan , Yang Ming , Yao Lei , Song Naiqing
Published: April 2021

The Exercise Orientation Questionnaire (EOQ) is a method for evaluating individuals' exercise attitudes and behaviors associated with exercise motivation. A lack of exercise motivation can affect physical activity attitudes, behavior, and action among university students. Physical inactivity may lead to health risks. The purpose of this study was to assess the measurement of psychological properties in the EOQ and to determine the reliability and validity of the EOQ when applied to Chinese university students. A total of 368 university students (male 48.8%) aged between 17 and 23 years (M = 19.60, SD = 1.18) participated in the current study. Confirmatory factor analysis (CFA) and exploratory structural equation modeling (ESEM) were used to verify the factorial validity of the EOQ. The internal consistency coefficient (Cronbach's alpha and McDonald's omega) was used to determine reliability. Multiple regression analysis was used to test concurrent validity. The International Physical Activity Questionnaire (IPAQ) was used to determine the participants' level of physical activity. The range of the subscale coefficient was 0.80–0.89, and the total scale was 0.95, which indicated that the reliability of the EOQ was excellent. The research showed that the initial CFA model of the EOQ had poorly fitting indices. The corrected model after seven residual correlations achieved the setting standard, but the correlation coefficient between some factors exceeded the standard threshold, which indicated that the CFA fitting model was not ideal. ESEM is a combination of exploratory and verifiable analytical techniques. Using ESEM and abbreviated version CFA to analyze the data indicated that the model fitted well [ESEM: TLI = 0.97 > 0.90, CFI = 0.96 > 0.90, SRMR = 0.02 < 0.08, and RMSEA = 0.045 < 0.08 (90% CI 0.033–0.055); CFA: TLI = 0.92 > 0.90, CFI = 0.91 > 0.90, SRMR = 0.08, and RMSEA = 0.06 < 0.08 (90% CI 0.055–0.067)]. The results of multiple regression analysis suggested that the ESEM model was effective in distinguishing the differences between individuals with different levels of physical activity (PAL) and body mass index (BMI). Overall, the Chinese abbreviated version of the EOQ (EOQ-CA) was fond to be a reliable tool for monitoring the exercise attitudes and behaviors of Chinese University students.
“Our Home Is a Muddy Structure”: Perceptions of Housing and Health Risks Among Older Adults in Contrasting Neighborhoods in Ghana
Authors: Alaazi Dominic A. , Stafinski Tania , Evans Joshua , Hodgins Stephen , Oteng-Ababio Martin , Menon Devidas
Published: April 2021

Aging occurs in a variety of social and physical environmental settings that affect health. However, despite their rapidly growing populations, public health research in sub-Saharan Africa has yet to address the role of residential environments in the health and well-being of older adults. In this study, we utilized an ethnographic research methodology to explore barriers and facilitators to health among older adults residing in two contrasting neighborhoods in Accra, Ghana. Our specific objective was to identify patterns of health risks among older adults in the two neighborhoods. Data were collected through qualitative interviews with a purposive sample of health workers (n = 5), community leaders (n = 2), and older adults residing in a slum and non-slum neighborhood (n = 30). Our thematic data analysis revealed that, despite different underlying drivers, health barriers across the slum and non-slum were largely similar. The harmful effects of these health barriers – poor built environments, housing precariousness, unsanitary living conditions, defective public services, and social incivilities – were mitigated by several facilitators to health, including affordable housing and social supports in the slum and better housing and appealing doors in the non-slum. Our study contributes to a more nuanced understanding of the ways in which aging and urban environments intersect to influence population health in resource poor settings. In particular, rather than the commonly referenced dichotomy of poor and non-poor settlements in discourses of neighborhood health, our findings point to convergence of health vulnerabilities that are broadly linked to urban poverty and governmental neglect of the elderly.
Pick the Freshmen Up for a “Healthy Study Start” Evaluation of a Health Promoting Onboarding Program for First Year Students at the Carinthia University of Applied Sciences, Austria
Authors: Limarutti Andrea , Maier Marco Johannes , Mir Eva , Gebhard Doris
Published: April 2021

Introduction: Universities are an essential setting for creating health promoting environments. Evidence shows that university life can pose various threats to the students' health. Especially first year students are vulnerable to mental health issues. To support well-being and prevent psychological distress from the first day of studying, onboarding programs are needed to promote the students' health and their self- and social competencies. The study demonstrates a tailored multi-component onboarding intervention program named “Healthy Study Start.” An evaluation of the effectiveness is presented focusing on outcomes regarding the students' sense of coherence (S-SoC), social support, sympathy, the work-related collective and the participative safety (a sub-scale of the team climate) among freshmen at the Carinthia University of Applied Sciences (CUAS, Austria).

Methods: For the analyses, a quantitative controlled study design was used and results were measured three times. The intervention group (n = 72) was composed of freshmen selected from the bachelor study programs Occupational Therapy, Speech and Language Therapy, Biomedical Science and Radiologic Technology. Freshmen from the bachelor study program Healthcare and Nursing formed the control group (n = 81). As the requirements for analyses of variance were not fulfilled, the data had to be analyzed using e.g., Mann-Whitney U-tests.

Results: Significant changes (all p < 0.016) between the two groups were found between T0/T1, and between T0/T2. Furthermore, changes within the intervention group (all p < 0.016) emerged in nearly all outcomes between T0/T1, while within the control group no changes were identified. However, the intervention group had statistically significantly higher values in the majority of outcomes at T1 and T2 compared to the control group.

Conclusion: The onboarding program “Healthy Study Start” shows how an initiative at the beginning of their studies can support students in entering a new phase of their lives. The results indicate a positive effect on the students' self- and social competencies. However, students' health promotion is not only an investment for a health conscious university or an enhanced employability. Especially in health-related fields of study, students are future multipliers and play an essential role in implementing health promotion concepts for clients, patients and employees.
“A Labour of Love”: Active Lifestyle Entrepreneurship (Occupational Devotion) During a Time of COVID-19
Authors: Wright Richard Keith , Wiersma Cindy , Ajiee Richard Opara
Published: April 2021

The Novel Coronavirus (COVID-19) crisis management strategies adopted by world leaders across the globe in 2020 impacted the work-life balance of billions of people. Entire populations were forced to stay at home and maintain a safe distance from family members, friends, colleagues, and customers. Occupational devotion is defined as a feeling of strong, positive attachment to a form of self-enhancing employment, where achievement and fulfillment are high, and the core activity has such intense appeal that the line between this work and leisure is virtually erased. Although it is not a new concept, this area of the serious leisure perspective has been largely overlooked by scholars observing the world of sport events and entrepreneurship. Using Creative Analytical Practice (CAP), a post-qualitative methodology, we present the personal narrative of a New Zealand-based active lifestyle entrepreneur who, as a result of a nationwide COVID19 lockdown, was forced to re-assess his long-established occupational devotion. Our co-constructed story offers an emotive insight into the personal cost and consequences of finding yourself living in a lockdown.
Effects of Graded Exergames on Fitness Performance in Elementary School Children With Developmental Coordination Disorder
Authors: Smits-Engelsman Bouwien , Bonney Emmanuel , Ferguson Gillian
Published: April 2021

Developmental Coordination Disorder (DCD) is a common childhood disorder affecting movement and coordination skills, fitness, and academic performance. Increased physical fitness may have a positive influence on physical and mental health outcomes in children with DCD. Yet, little has been done to develop interventions to improve fitness performance in this group. The purpose of this study was to determine the effects of graded exergames in 7 to 12-year-old children with DCD and typically developing (TD) peers. Participants (32 DCD and 28 TD children) received a 30-min training session twice weekly for 10 weeks. Performance on motor coordination (MABC-2 test), balance, aerobic, and anaerobic fitness tests were assessed at the beginning and end of training. In addition, enjoyment and perception of exertion were measured for each participant during the training period. Both children with DCD and TD children significantly improved on motor coordination, balance, aerobic, and anaerobic fitness at the end of the training. A significant Group by Time interaction was observed on the MABC-2 total [F(1, 55) = 13.19; p < 0.001] and balance scores [F(1, 55) = 26.83; p < 0.0001], with the DCD group demonstrating larger improvements than the TD children. Both groups enjoyed the program throughout the training period even though they rated the training to be of high intensity. These findings indicate that graded exergames may serve as potential treatment for impaired fitness in children with DCD. Regular participation in graded exergames in school settings may be needed to enhance and maintain fitness performance in young children with and without DCD.
Choice of Pole and Ski Lengths Among Elite Cross-Country Skiers: The Influence of Sex and Performance Level
Authors: Torvik Per-Øyvind , van den Tillaar Roland , Sandbakk Øyvind
Published: April 2021

Cross-country (XC) skiers employ whole-body exercise to generate speed through poles and skis. The choice of optimal pole and ski lengths are therefore of high importance. The aim of this study was to document pole and ski lengths among elite male and female cross-country skiers in the classical and skating styles and to investigate sex differences in body-height-normalized pole and ski lengths. Our secondary purpose was to correlate body-height-normalized pole and ski lengths with performance level within both sexes. In total, Norwegian men and women (n = 87 and 36, respectively), participating in the Norwegian XC championship 2020, were investigated. Most athletes used poles close to the length allowed by the International Ski Federation (FIS) in the classical style among both sexes, with men using slightly longer poles than women (p < 0.05). Body-height-normalized pole lengths in skating were similar in men and women (around 90% of body height). Women used relatively longer ski lengths than men in both styles (p < 0.05). Women showed moderate correlations (r = 0.43, p < 0.05) between body-height-normalized pole lengths and sprint performance. Male and female cross-country skiers use as long classical ski poles as possible within the current regulations, while they use skating poles similar to recommendations given by the industry. The fact that men use longer body-height-normalized poles than women, where there is a correlation between pole length and sprint performance, indicate that faster women are able to better utilize the potential of using longer poles when double-poling. However, while women use relatively longer skis than men, no correlation with performance occurred for any of the sexes.
The Effects of Prioritizing Lead or Boulder Climbing Among Intermediate Climbers
Authors: Stien Nicolay , Frøysaker Tor Frithjof , Hermans Espen , Vereide Vegard Albert , Andersen Vidar , Saeterbakken Atle Hole
Published: April 2021

This study compared the effects of prioritizing lead climbing or boulder climbing on climbing-specific strength and endurance, as well as climbing performance. Fourteen active climbers were randomized to a boulder climbing training group (BCT: age = 27.2 ± 4.4 years, body mass = 65.8 ± 5.5 kg, height = 173.3 ± 3.8 cm) or a lead-climbing training group (LCT: age = 27.7 ± 6.1 years, body mass = 70.2 ± 4.4 kg, height = 177.7 ± 4.4 cm). The groups participated in a 5-week training period consisting of 15 sessions, performing either two weekly bouldering sessions and one maintenance-session of lead-climbing (BCT) or two weekly lead-climbing sessions and one maintenance-session of bouldering (LCT). Pre- and post-training, maximal force and rate of force development (RFD) were measured during isometric pull-ups performed on a jug hold and a shallow rung, and during an isolated finger-strength test. Lead-climbing and bouldering performance were also measured, along with an intermittent forearm endurance test. The pre-to-post changes were not significantly different between the groups for any of the parameters (P = 0.062–0.710). However, both the BCT (ES = 0.30, P = 0.049) and LCT (ES = 0.41, P = 0.046) groups improved strength in the isometric pull-up performed using the jug, whereas neither group improved force in the rung condition (P = 0.054 and P = 0.084) or RFD (P = 0.060 and P = 0.070). Furthermore, climbing and bouldering performance remained unchanged in both groups (P = 0.210–0.895). The LCT group improved forearm endurance (ES = 0.55, P = 0.007), while the BCT group improved isolated finger strength (ES = 0.35, P = 0.015). In addition to isometric pull-up strength, bouldering can increase isolated finger strength while lead-climbing may improve forearm endurance. A 5-week period prioritizing one discipline can be safely implemented for advanced to intermediate climbers without risking declined performance in the non-prioritized discipline.
Survey on Antimicrobial Drug Use Practices in California Preweaned Dairy Calves
Authors: Okello Emmanuel , Williams Deniece R. , ElAshmawy Wagdy R. , Adams Jaymes , Pereira Richard V. , Lehenbauer Terry W. , Aly Sharif S.
Published: April 2021

The California (CA) dairy industry was surveyed in July 2017 to evaluate producers' knowledge and perceptions and antimicrobial drug (AMD) use in preweaned dairy calves following the implementation of the nationwide veterinary feed directive final rule (VFD) in January 2017 and prior to statewide implementation of CA Senate Bill (SB) 27 in January 2018. Together, these regulations require veterinary oversight for all uses of medically important antimicrobial drugs (MIADs) administered to livestock in CA. Survey questionnaire was mailed to 1,361 CA Grade A milk producing dairies and calf ranches across CA resulting in a 12% (169) response. Most respondents (83%) were aware of the VFD and SB 27 changes. Use of antibiotics was perceived as important (77%) in raising preweaned dairy calves and judicious use of antibiotics was ranked as the most important antimicrobial stewardship practice, amongst record keeping, observing withdrawal periods, having a valid Veterinarian-Client-Patient-Relationship (VCPR), and use of alternatives to antibiotics. Treating sick calves was the major indication for AMD use (90.5%); however, few producers reported use of antibiotics to control (12.7%) or prevent disease (11%). Neomycin sulfate, chlortetracycline, oxytetracycline and sulfamethazine were the most used AMD. The respondents reported a decreased use of AMD in milk (10%) and in solid feed (5%), and discontinuation of one or more AMDs used in milk (18.6%) or in solid feed (5%) post-VFD rule implementation in 2017. Most respondents reported keeping treatment records and the information recorded included date (82%), dose (44%) and route (15%) of AMD used. A few respondents reported they had initiated use of alternatives to AMDs, such as vitamins (32.6%), minerals (25.6%), herbal remedies (11.6%) and pathogen specific antibodies (7%), post-VFD. The limited changes noted in AMD use could be attributed to the short period between the implementation of the VFD and the time of the survey. Our study outcomes identified opportunities to improve AMD use practices, including record keeping and use of AMD alternatives, and provides a baseline for future evaluation of the impact of these regulatory changes, as well as guidance for the future recommendations on best practices to promote judicious AMD use.
Sequencing of the Canine Cytochrome P450 CYP2C41 Gene and Genotyping of Its Polymorphic Occurrence in 36 Dog Breeds
Authors: Karakus Emre , Prinzinger Clarissa , Leiting Silke , Geyer Joachim
Published: April 2021

Cytochrome P450 (CYP) drug metabolizing enzymes play an important role in efficient drug metabolism and elimination. Many CYPs are polymorphic and, thereby, drug metabolism can vary between individuals. In the case of canine CYP2C41, gene polymorphism was identified. However, as the first available canine genome sequences all were CYP2C41 negative, this polymorphism could not be clarified at the genomic level. The present study provides an exact characterization of the CYP2C41 gene deletion polymorphism at the genomic level and presents a PCR-based genotyping method that was used for CYP2C41 genotyping of 1,089 individual subjects from 36 different dog breeds. None of the Bearded Collie, Bernese Mountain, Boxer, Briard, French Bulldog or Irish Wolfhound subjects had the CYP2C41 gene in their genomes. In contrast, in the Chinese Char-Pei, Siberian Husky, Schapendoes and Kangal breeds, the CYP2C41 allele frequency was very high, with values of 67, 57, 43, and 34%, respectively. Interestingly, the site of gene deletion was identical for all CYP2C41 negative dogs, and all CYP2C41 positive dogs showed highly homologous sequence domains upstream and downstream from the CYP2C41 gene. CYP2C41 genotyping can now be routinely used in future pharmacokinetic studies in canines, in order to identify genetically-based poor or extensive drug metabolizers. This, together with more extensive in vitro drug screening for CYP2C41 substrates will help to determine the clinical relevance of CYP2C41, and to optimize drug treatment. Although the relative abundance of the CYP2C41 protein in the canine liver seems to not be very high, this CYP could substantially contribute to hepatic drug metabolism in dogs expressing CYP2C41 from both alleles and, when CYP2C41 shows higher catalytic activity to a given drug than other hepatic metabolic enzymes.
Histomorphometric Quantitative Evaluation of Long-Term Risedronate Use in a Knee Osteoarthritis Rabbit Model
Authors: Fernández-Martín Silvia , González-Cantalapiedra Antonio , Permuy María , García-González Mario , López-Peña Mónica , Muñoz Fernando
Published: April 2021

Osteoarthritis (OA) treatment is a major orthopedic challenge given that there is no ideal drug capable to reverse or stop the progression of the OA. In that regard, bisphosphonates have been proposed as potential disease-modifying drugs due to their possible chondroprotective effect related to obtaining a greater subchondral bone quality. However, their effectiveness in OA is still controversial and additionally, there is little evidence focused on their long-term effect in preclinical studies. The aim of this study was to evaluate the risedronate quantitative effect on articular and subchondral periarticular bone by histomorphometry, in an experimental rabbit model in an advanced stage of OA. Twenty-four adult New Zealand rabbits were included in the study. OA was surgically induced in one randomly chosen knee, using the contralateral as healthy control. Animals were divided into three groups (n = 8): placebo control group, sham surgery group and risedronate-treated group. After 24 weeks of treatment, cartilage and subchondral femorotibial pathology was evaluated by micro-computed tomography (micro-CT) and undecalcified histology. The research results demonstrated that the experimental animal model induced osteoarthritic changes in the operated joints, showing an increased cartilage thickness and fibrillation associated with underlying subchondral bone thinning and decreased trabecular bone quality. These changes were especially highlighted in the medial tibial compartments as a possible response to surgical instability. Regarding the trabecular analysis, significant correlations were found between 2D histomorphometry and 3D imaging micro-CT for the trabecular bone volume, trabecular separation, and the trabecular number. However, these associations were not strongly correlated, obtaining more precise measurements in the micro-CT analysis. Concerning the long-term risedronate treatment, it did not seem to have the capacity to reduce the osteoarthritic hypertrophic cartilage response and failed to diminish the superficial cartilage damage or prevent the trabecular bone loss. This study provides novel information about the quantitative effect of long-term risedronate use on synovial joint tissues.