bluuebunny/crossref_metadata_2025 huggingface dataset:
Geodesics on metrics of Eguchi–Hanson type
Authors: Yang Yekun , Zhang Xiao
Published: July 2023

Geodesic equations are solved when at least two of $$\theta $$
θ
, $$\phi $$
ϕ
and $$\psi $$
ψ
are constant, or r is constant, on scalar flat metrics of Eguchi–Hanson type. They can also be solved also on Eguchi–Hanson metrics which are Ricci flat if only $$\phi $$
ϕ
is constant. However, the explicit solution of the geodesic equations is not available yet if only $$\psi $$
ψ
is constant.
A method for achieving perfect acoustic black hole structure by impedance mutation
Authors: Liang Xiao , Liang Haofeng , Chu Jiaming , Zhou Zhuo , Yang Zhen , Nie Songhui , Hu Congfang , Wu JiuHui , Zhou Jiaxi , Wang Qiang , Liu A. Q.
Published: July 2023

The suppression of low-frequency waves has been a challenging task for acoustic black hole (ABH) because a small truncation of the ABH tip would fail to prevent the transmission of low-frequency waves below the cutoff frequency. Here, we propose a novel approach to achieve perfect ABH to suppress the wave propagation at low frequencies in the range of 3–100[Formula: see text]Hz. Structurally, the perfect ABH consists of two ABHs with rigid materials and a soft material connected between the two ABHs to break the cutoff frequency limit and achieve attenuation of up to 21.3[Formula: see text]dB in the 3–20[Formula: see text]Hz range. The wave energy focusing effect possessed by ABHs, combined with the impedance mutation on the surface where soft and hard materials are connected, can concentrate the wave energy within the soft material, thus achieving a perfect ABH effect. The proposed perfect ABH compensates the defect that ABH cannot suppress low-frequency and sub-low-frequency waves, and provides the possibility of full-band suppression.
Managing a Case of Refractory Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Associated Dermatomyositis with Recent COVID-19 Infection
Authors: Ng Cheryl Chun Man , Leung Alexander Moon Ho
Published: July 2023

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody positive dermatomyositis is known to associate with rapidly progressive interstitial lung disease and cutaneous ulcer. The prognosis is often poor even with intensive treatment, with data from the local cohort showing 37.9% mortality [1]. Here, we report a case of refractory anti-MDA5 antibody-associated dermatomyositis that occurs shortly after COVID-19 infection and was managed using a combination of treatments that target different aspects of disease pathology.
A Liquid and Waste-free Method for Preparing Single Crystal Positive Electrode Materials for Li-ion Batteries
Authors: Zhang Ning , Yu Haifeng , Murphy Aidan , Garayt Matthew , Yu Svena , Rathore Divya , Leontowich Adam , Bond Toby , Kim Chang-Yong , Dahn J. R.
Published: July 2023

Nickel-rich layered positive electrode materials are normally made by a “co-precipitation-sintering” method. Mixed transition metal hydroxides called “precursors” are prepared by co-precipitation to ensure homogeneous cation mixing at the atomic level and to create spherical particles which ensure high-performance poly-crystalline materials. Single crystal materials, which show better capacity retention in long-term cycling can be made from the same mixed transition metal hydroxide precursors by sintering at a higher temperature which inevitably destroys the spherical morphology present in the initial precursors. Here we describe a method for single crystal positive electrode material production which we call “all-dry synthesis” since it does not require the use of any liquid and creates no waste unlike the co-precipitation method. The exemplary reaction between Ni, MnCO3, and LiOH·H2O was studied in situ by synchrotron XRD in order to define a proper heating scheme for the all-dry process. The crystal structure, particle morphology, surface residual impurities, and electrochemical performance of materials prepared by the “all-dry synthesis” method are equivalent to or even better than those of materials made using a conventional co-precipitation method.
Correlation between Post‐Thaw Spermatozoa Quality of the Endangered Javan Banteng with OPN Gene Expression
Authors: Yoelinda Vincentia Trisna , Arifiantini Raden Iis , Solihin Dedy Duryadi , Agil Muhammad , Setiadi Dedi Rahmat , Maulana Tulus , Purwantara Bambang , Hastuti Yohana Tri , Manansang Jansen , Sajuthi Dondin
Published: July 2023

The role of ex situ conservation facilities or captivity through captive breeding programs is essential in the conservation of the endangered Javan banteng. The development of semen cryopreservation may assist on one side of the conservation plan. However, the male Javan banteng reproductive capability must be considered as it influences the targeted outputs. Studying the potential biomarker for fertility such as osteopontin gene expression is also expected to help predict male fertility. Therefore, this study aimed to analyze the quality of spermatozoa after thawing to help predict the male reproductive capability of Javan banteng. Furthermore, this study investigated the potential role of osteopontin gene expression in male Javan banteng fertility. A positive reinforcement approach was used to accustom the male and female animals as we focused on establishing a collection procedure using neither sedation nor anaesthesia. Semen samples were collected at Taman Safari Indonesia, Bogor, in accordance with the female banteng receptivity. Semen samples were then evaluated and then cryopreserved under field conditions. Our study showed the different predicted reproductive capability of the Javan banteng based on the post‐thaw spermatozoa quality, which showed significant differences. The OPN gene showed positive correlations with the progressive motility (r = 0.711, p = 0.048), viability (r = 0.822, p = 0.012), and acrosomal integrity (r = 0.665, p = 0.072) of Javan banteng spermatozoa after thawing. Our study demonstrated the predicted Javan banteng reproductive capability based on various post‐thaw spermatozoa variables. This finding is also the first report on the OPN gene potential to be developed as the assessment tool of post‐thaw spermatozoa quality of the male Javan banteng. The findings in our study may help give recommendations for future breeding programs, especially in the ex situ conservation sites.
Data from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: July 2023

Abstract
Mutations in Fms-like tyrosine kinase 3 (FLT3) are common drivers in acute myeloid leukemia (AML) yet FLT3 inhibitors only provide modest clinical benefit. Prior work has shown that inhibitors of lysine-specific demethylase 1 (LSD1) enhance kinase inhibitor activity in AML. Here we show that combined LSD1 and FLT3 inhibition induces synergistic cell death in FLT3-mutant AML. Multi-omic profiling revealed that the drug combination disrupts STAT5, LSD1, and GFI1 binding at the MYC blood superenhancer, suppressing superenhancer accessibility as well as MYC expression and activity. The drug combination simultaneously results in the accumulation of repressive H3K9me1 methylation, an LSD1 substrate, at MYC target genes. We validated these findings in 72 primary AML samples with the nearly every sample demonstrating synergistic responses to the drug combination. Collectively, these studies reveal how epigenetic therapies augment the activity of kinase inhibitors in FLT3-ITD (internal tandem duplication) AML.
Implications:
This work establishes the synergistic efficacy of combined FLT3 and LSD1 inhibition in FLT3-ITD AML by disrupting STAT5 and GFI1 binding at the MYC blood-specific superenhancer complex.
Table S5 from Proteogenomic approaches for the identification of NF1/neurofibromin-depleted estrogen receptor positive breast cancers for targeted treatment
Authors: Kim Beom-Jun , Zheng Ze-Yi , Lei Jonathan T. , Holt Matthew V. , Chen Anran , Peng Jianheng , Fandino Diana , Singh Purba , Kennedy Hilda , Dou Yongchao , Chica-Parrado María del Rosario , Bikorimana Emmanuel , Ye Dan , Wang Yunguan , Hanker Ariella B. , Mohamed Nada , Hilsenbeck Susan G. , Lim Bora , Asirvatham Jaya Ruth , Sreekumar Arun , Zhang Bing , Miles George , Anurag Meenakshi , Ellis Matthew J. , Chang Eric C
Published: July 2023

Table S5. Ki67 and NF1 protein levels in the POL cohort.
Table S2 from Proteogenomic approaches for the identification of NF1/neurofibromin-depleted estrogen receptor positive breast cancers for targeted treatment
Authors: Kim Beom-Jun , Zheng Ze-Yi , Lei Jonathan T. , Holt Matthew V. , Chen Anran , Peng Jianheng , Fandino Diana , Singh Purba , Kennedy Hilda , Dou Yongchao , Chica-Parrado María del Rosario , Bikorimana Emmanuel , Ye Dan , Wang Yunguan , Hanker Ariella B. , Mohamed Nada , Hilsenbeck Susan G. , Lim Bora , Asirvatham Jaya Ruth , Sreekumar Arun , Zhang Bing , Miles George , Anurag Meenakshi , Ellis Matthew J. , Chang Eric C
Published: July 2023

Table S2. Correlations between kinase levels as determined by KIPA and NF1 status in the POL cohort.
Figure S3 from Proteogenomic approaches for the identification of NF1/neurofibromin-depleted estrogen receptor positive breast cancers for targeted treatment
Authors: Kim Beom-Jun , Zheng Ze-Yi , Lei Jonathan T. , Holt Matthew V. , Chen Anran , Peng Jianheng , Fandino Diana , Singh Purba , Kennedy Hilda , Dou Yongchao , Chica-Parrado María del Rosario , Bikorimana Emmanuel , Ye Dan , Wang Yunguan , Hanker Ariella B. , Mohamed Nada , Hilsenbeck Susan G. , Lim Bora , Asirvatham Jaya Ruth , Sreekumar Arun , Zhang Bing , Miles George , Anurag Meenakshi , Ellis Matthew J. , Chang Eric C
Published: July 2023

Figure S3. Proteogenomic analyses of key biomarkers in the PDXs selected for treatment.
Supplementary Figure 9 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma
Authors: Nisnboym Michal , Vincze Sarah R. , Xiong Zujian , Sneiderman Chaim T. , Raphael Rebecca A. , Li Bo , Jaswal Ambika P. , Sever ReidAnn E. , Day Kathryn E. , LaToche Joseph D. , Foley Lesley M. , Karimi Hanieh , Hitchens T. Kevin , Agnihotri Sameer , Hu Baoli , Rajasundaram Dhivyaa , Anderson Carolyn J. , Blumenthal Deborah T. , Pearce Thomas M. , Uttam Shikhar , Nedrow Jessie R. , Panigrahy Ashok , Pollack Ian F. , Lieberman Frank S. , Drappatz Jan , Raphael Itay , Edwards Wilson B. , Kohanbash Gary
Published: July 2023

Pearson's correlation coefficients analysis between immuno-PET signals and survival in ICI and control groups.
Supplementary Figure 5 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma
Authors: Nisnboym Michal , Vincze Sarah R. , Xiong Zujian , Sneiderman Chaim T. , Raphael Rebecca A. , Li Bo , Jaswal Ambika P. , Sever ReidAnn E. , Day Kathryn E. , LaToche Joseph D. , Foley Lesley M. , Karimi Hanieh , Hitchens T. Kevin , Agnihotri Sameer , Hu Baoli , Rajasundaram Dhivyaa , Anderson Carolyn J. , Blumenthal Deborah T. , Pearce Thomas M. , Uttam Shikhar , Nedrow Jessie R. , Panigrahy Ashok , Pollack Ian F. , Lieberman Frank S. , Drappatz Jan , Raphael Itay , Edwards Wilson B. , Kohanbash Gary
Published: July 2023

Equilibrium dissociation constants of anti-CD69 Abs clone CD69.2.2 and H1.2F3.
FIGURE 5 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma
Authors: Nisnboym Michal , Vincze Sarah R. , Xiong Zujian , Sneiderman Chaim T. , Raphael Rebecca A. , Li Bo , Jaswal Ambika P. , Sever ReidAnn E. , Day Kathryn E. , LaToche Joseph D. , Foley Lesley M. , Karimi Hanieh , Hitchens T. Kevin , Agnihotri Sameer , Hu Baoli , Rajasundaram Dhivyaa , Anderson Carolyn J. , Blumenthal Deborah T. , Pearce Thomas M. , Uttam Shikhar , Nedrow Jessie R. , Panigrahy Ashok , Pollack Ian F. , Lieberman Frank S. , Drappatz Jan , Raphael Itay , Edwards Wilson B. , Kohanbash Gary
Published: July 2023

Immuno-PET of 89Zr-DFO-CD69 Ab as a prognostic predictor after ICI treatment in a GBM mouse model. Survival follow-up of mice inoculated with GL261 cells, and evaluated by immuno-PET of 89Zr-DFO-CD69 Ab, comparing treatment (ICI) group to control group (represented by orange and blue dots, respectively). A, Schematic showing timeline of tumor inoculation, ICI treatment, MRI, tail vein injection of 89Zr-DFO-CD69 Ab, immuno-PET, and survival follow-up. B, The overall survival (OS) rates of the ICI-treated group and control group are plotted using Kaplan–Meier survival curves, with log-rank (Mantel–Cox) curve comparison test. C, Right, heat map display of Pearson correlation coefficient analysis between immuno-PET signals and survival in the two groups. Results are shown for each SUV measurement method (SUVmax, SUVmax TBR, SUVmean, and SUVmean TBR) in each immuno-PET designated time point (days 1, 2, 3, 4, and 6). Shown are representative data of two independent experiments, n = 4–5 mice per group (*, P < 0.05; **, P <0.01). Left, examples of scatter diagrams of Pearson correlation coefficient taken from immuno-PETs on day 2 of SUVmax and SUVmax TBR. Scattered dots represent individual mice, n = 4–5 mice per group.
FIGURE 3 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma
Authors: Nisnboym Michal , Vincze Sarah R. , Xiong Zujian , Sneiderman Chaim T. , Raphael Rebecca A. , Li Bo , Jaswal Ambika P. , Sever ReidAnn E. , Day Kathryn E. , LaToche Joseph D. , Foley Lesley M. , Karimi Hanieh , Hitchens T. Kevin , Agnihotri Sameer , Hu Baoli , Rajasundaram Dhivyaa , Anderson Carolyn J. , Blumenthal Deborah T. , Pearce Thomas M. , Uttam Shikhar , Nedrow Jessie R. , Panigrahy Ashok , Pollack Ian F. , Lieberman Frank S. , Drappatz Jan , Raphael Itay , Edwards Wilson B. , Kohanbash Gary
Published: July 2023

CD69 expression increases on TILs following ICI treatment in patients with GBM. A–C, scRNA-seq analysis of sorted CD45+ immune cells (n  =  156,766 cells) from 40 patients with GBM: 14 GBM.new, 12 GBM.rec, and 14 GBM.pembro. A, UMAP cell clustering analysis of tumor cell cluster (SOX4; top right), myeloid cell cluster (CD14; middle right), and lymphocyte cluster (CD3D; bottom right). B, UMAP data color-coded by the expression of CD3 (red), CD69 (purple; top), and coexpression (merge) in each group of patients (bottom). C, Dot plot analysis of cells within the lymphocyte cluster; the size of the dots corresponds to the percentage of cells expressing the feature (gene). The color represents the average expression level.
FIGURE 1 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma
Authors: Nisnboym Michal , Vincze Sarah R. , Xiong Zujian , Sneiderman Chaim T. , Raphael Rebecca A. , Li Bo , Jaswal Ambika P. , Sever ReidAnn E. , Day Kathryn E. , LaToche Joseph D. , Foley Lesley M. , Karimi Hanieh , Hitchens T. Kevin , Agnihotri Sameer , Hu Baoli , Rajasundaram Dhivyaa , Anderson Carolyn J. , Blumenthal Deborah T. , Pearce Thomas M. , Uttam Shikhar , Nedrow Jessie R. , Panigrahy Ashok , Pollack Ian F. , Lieberman Frank S. , Drappatz Jan , Raphael Itay , Edwards Wilson B. , Kohanbash Gary
Published: July 2023

ICIs influence T-cell distribution in tumor and spleen. Mice (n = 28) were inoculated with GL261 cells, treated with ICI or vehicle control, and analyzed at the designated time points relative to treatment. A, Schematic showing tumor inoculation day, treatment days, and time points relative to treatment in which mice were analyzed. B, Percentage of CD8+ TILs (red dots) and CD4+ TILs (blue dots) in each time point relative to treatment, for vehicle-control group (left panel) and ICI-treated group (right panel) C, Absolute number of TILs per mm3 of tumor. CD8+ cells × 102 (upper panels; red dots) and CD4+ cells × 102 (bottom panels; blue dots) in each time point relative to treatment, for ICI-treated group and vehicle-control group. D, Frequencies of CD8+ (red dots) and CD4+ T-cells (blue dots) in spleen in each time point relative to treatment, for vehicle-control group and ICI-treated group. B–D, Shown are means ± SEM. Scattered dots represent individual mice. Shown are representative data of two independent experiments. n = 3–4 per group. CD8+ and CD4+ were gated from CD3+CD45+ cells. One-way ANOVA with multiple comparison test (*, P < 0.05; **, P <0.01; ***, P <0.001).
The Effectiveness of Lemongrass (Cymbopogon Nardus) Aromatherapy on the Level of Labor Pain in the Active Phase 1
Authors: Andarwulan Setiana , Waroh Yuni Khoirul , Hubaedah Annah
Published: July 2023

Background: Labour pain causes hyperventilation, increasing the need for oxygen and blood pressure and reducing intestinal motility and urinary bladder. These conditions will interfere with uterine contractions, which can cause uterine inertia, prolonged labour, inadequate baby oxygenation that results in foetal distress, and maternal and/or foetal death. if labour pain is not treated. Aromatherapy is a therapeutic action that uses essential oils. which is beneficial in improving one's physical and psychological condition to be better. Each essential oil has unique pharmacological effects, such as antibacterial, antiviral, sedative, and stimulates the adrenals.

Methods The type of research used in this research is quantitative with a quasi-experimental research design. The research design used was a two-group prepost-test design, a research activity that gave an initial test (pretest) before treatment, after treatment, and then a final test (post-test). The population in this study were all 29 primigravida mothers. The sample was 21 mothers with primigravida. The independent variable in this study was lemongrass aromatherapy, which was measured using standard operating procedures for aromatherapy. The dependent variable in this study was the reduction in pain measured using the NRS scale. The data analysis technique used was univariate data analysis using frequency descriptions and bivariate statistical tests using Wilcoxon signed.

Results: The value of p = 0.002 (α < 0.05) was obtained. Therefore, it was concluded that there were differences in pain changes before and after the lemongrass aromatherapy group. Giving lemongrass aromatherapy to pain in the first stage of labour is effective.

Conclusion: A woman giving birth during the first active phase needs support to maintain her motivation to birth normally and cope with any discomfort she may experience. Lemongrass aromatherapy, given as a gift, can be used to ease the discomfort of labor, improving both the mother's experience and her ability to trust the process.
O que podemos aprender com obras de arte sobre autonomia em saúde de crianças com condições crônicas complexas?
Authors: Rocha Aline Maria de Oliveira , Gobbetti Gisele Joana
Published: July 2023

O debate sobre autonomia de crianças e adolescentes com condições crônicas complexas – estas definidas como qualquer doença em que se espera duração de pelo menos 12 meses com acometimento de múltiplos órgãos ou sistemas, necessitando de acompanhamento especializado – traz temáticas pungentes e reflexões importantes para aqueles que lidam diretamente com o cuidado destes. Entendendo que essas decisões devem ser guiadas baseadas no respeito à dignidade humana e visando o melhor interesse da criança, perguntamo-nos a quem cabe definir qual é este melhor interesse e como se insere a criança ou o adolescente envolvido na demonstração de vontades, valores e interesses próprios. As discussões são múltiplas, e deste ponto advêm considerações relevantes quanto a relações da criança, sua dependência e vulnerabilidade e sua capacidade evolutiva de tomadas de decisão. Este desafio para uma relação respeitosa à autonomia da criança será o objetivo de discussão deste artigo. Foi realizada uma análise reflexiva tendo como perguntas norteadoras: “Como a criança e o adolescente podem aplicar sua autonomia nas decisões em saúde?”; “Como conversar com crianças e familiares sobre a adequação do suporte à saúde?”; “Como se insere a criança ou o adolescente envolvidos na demonstração de vontades, valores e interesses próprios?”, “Quem é o responsável pelo melhor interesse da criança e do adolescente nas tomadas de decisão em saúde?”, e levantando como pontos de debate o livro A Balada de Adam Henry e os filmes Um ato de esperança (título original The children act) e Uma prova de amor (título original My sister’s keeper). Em torno desse livro e filmes giraram discussões sobre questões éticas relacionadas à autonomia na tomada de decisão em saúde de crianças e adolescentes, requisitos e avaliação para estas tomadas de decisão, conflitos entre família, equipe de saúde e paciente, adequação de medidas de suporte à vida, dentre outras.
Cross-Tissue Single-Nucleus RNA Sequencing Discovers Tissue-Resident Adipocytes Involved in Propanoate Metabolism in the Human Heart
Authors: Das Sankha Subhra , Kar Asha , Rajkumar Sandhya , Lee Seung Hyuk T. , Alvarez Marcus , Pietiläinen Kirsi H. , Pajukanta Päivi
Published: July 2023

BACKGROUND:

Adipocytes are crucial regulators of cardiovascular health. However, not much is known about gene expression profiles of adipocytes residing in nonfat cardiovascular tissues, their genetic regulation, and contribution to coronary artery disease. Here, we investigated whether and how the gene expression profiles of adipocytes in the subcutaneous adipose tissue differ from adipocytes residing in the heart.

METHODS:

We used single-nucleus RNA-sequencing data sets of subcutaneous adipose tissue and heart and performed in-depth analysis of tissue-resident adipocytes and their cell-cell interactions.

RESULTS:

We first discovered tissue-specific features of tissue-resident adipocytes, identified functional pathways involved in their tissue specificity, and found genes with cell type–specific expression enrichment in tissue-resident adipocytes. By following up these results, we discovered the propanoate metabolism pathway as a novel distinct characteristic of the heart-resident adipocytes and found a significant enrichment of coronary artery disease genome-wide association study risk variants among the right atrium–specific adipocyte marker genes. Our cell-cell communication analysis identified 22 specific heart adipocyte-associated ligand-receptor pairs and signaling pathways, including THBS (thrombospondin) and EPHA (ephrin type-A), further supporting the distinct tissue-resident role of heart adipocytes. Our results also suggest chamber-level coordination of heart adipocyte expression profiles as we observed a consistently larger number of adipocyte-associated ligand-receptor interactions and functional pathways in the atriums than ventricles.

CONCLUSIONS:

Overall, we introduce a new function and genetic link to coronary artery disease for the previously unexplored heart-resident adipocytes.
The Salience of Salt Water: An ITLOS Advisory Opinion at the Ocean-Climate Nexus
Authors: Baars Lianne P.
Published: July 2023

As the Commission of Small Island States on Climate Change and International Law has communicated its request for an advisory opinion to the International Tribunal for the Law of the Sea (ITLOS), the Tribunal finds itself in a unique position to interpret the law of the sea in light of pressing, global challenges. This article explores how the ITLOS advisory opinion could support international efforts to combat climate change and ocean acidification, and encourages an evolutionary and mutually supportive interpretation that integrates the law of the sea with international legal systems concerning climate change, human rights, and biodiversity. Despite its non-binding character, the effects of this advisory opinion would then by no means be negligible. By embracing its judicial function, ITLOS could therefore – within the boundaries of the prevailing legal framework – offer guidance on climate change and ocean acidification that is backed up by the authority of the law.
Complementary description of Labidocera bataviae Scott, 1909, L. madurae Scott, 1909 and L. pavo Giesbrecht, 1889 (Copepoda, Calanoida, Pontellidae) in Indonesian waters
Authors: MULYADI  , SIDABALOK CONNI M. , HARYONO
Published: July 2023

Three species of Labidocera from Indonesian waters are herein redescribed based on topotypic material. Labidocera bataviae Scott, 1909, L. madurae Scott, 1909, and L. pavo Giesbrecht, 1889 are superficially similar in morphology that may easily be mistaken for each other. L. madurae is characterized by a moderately large and asymmetrical Ur1, with the middle of the right and the left sides considerably inflated; the CR almost symmetrical, the Ri’s of P5 asymmetrical, right side is longer, conically shaped and with tapered end, while the left side is short with rounded apex; Re armed with 3 unequal St in female. The male is characterized by the chela of the right P5 with stout and distally curved thumb, outer margin between thumb and distal end of Re1 naked, and the Re2 of the left P5 elongated, oval-shaped, and twice as long as wide: with 1 outer spine and 3 unequal terminal processes. Labidocera bataviae female is distinguishable by a moderately large and asymmetrical Ur1, with the right and left margins each armed with one knob-like process, and by the form of P5; the male by the bifurcated thumb of chela of the right P5. L. pavo female is distinguishable by having two large conical lobes on Ur1, and the form of P5; the male by the short thumb of chela of the right P5.
A new species of Askola Peters, 1969 (Ephemeroptera: Leptophlebiidae) from Southeastern Brazil
Authors: SALLES FREDERICO F. , JABEEN FATIMA
Published: July 2023

Askola fortuita sp. nov. is described based on male imagos from Southeastern Brazil, near Caparaó National Park. The new species is somewhat similar to A. froehlichi Peters, 1969 in regards to development of the male compound eyes and relative length of penis, but can be readily distinguished from this and other species of the genus by the following characteristics: dorsal portion of compound eyes widely meeting on meson of head; forewings hyaline; femora white, with a submedial mark and an apical band, both orangish brown; abdominal coloration mostly translucent white; genitalia with styliger plate washed with brown and red laterally, forceps segment I reddish-brown on basal ¼ , remainder translucent white, penes yellowish brown; penes not extending beyond posterior margin of styliger plate.
7. Why Limitarianism?
Authors: Robeyns Ingrid
Published: July 2023

This chapter responds to Robert Huseby’s critique that instrumental limitarianism is not genuinely limitarian. I first introduce the distinction between problem-driven versus theory-driven philosophy, which is relevant for assessing my earlier work on limitarianism. I then provide a restatement and refinement of limitarianism based on recent developments in the literature. I then argue that limitarianism is distinct from egalitarianism, as well as from sufficientarianism. Limitarianism fits well as one part of a pluralist account of distributive justice. I conclude by arguing that limitarianism could play a distinct role both within political philosophy, as well as within society.
14. Limitarianism and Future Generations
Authors: Meijers Tim
Published: July 2023

This chapter asks what role limitarianism can play in theorizing justice between generations. Do intergenerational challenges give us additional reasons to embrace limitarianism? Taking economic limitarianism as a starting point, I argue that both the democratic argument and the argument from basic needs have considerable intergenerational traction, but the latter raises difficult questions for limitarians. I also argue that economic limitarianism cannot offer a full account of intergenerational justice, due to its focus on individual and monetary holdings. We could design a more comprehensive limitarianism in response to these worries, but only at the cost of the appeal and distinctiveness of limitarianism. The last section somewhat speculatively develops a Rawls-inspired account of intergenerational limitarianism which stays true to the focus on monetary wealth, but with clear environmental implications.
2. Publishing, Editing, and Their Digital Transformation
Authors: Baillot Anne
Published: July 2023

This chapter focuses on literary texts. It discusses the shifts in text dissemination brought about by publishers in the European context. Publishers became essential professionals in the book market during the 18th and 19th centuries: this chapter examines how they contributed to shaping oeuvres of great authors, illustrated by the two examples of German writers Goethe and Tieck. It then bridges the gap to digitisation processes of modern textual heritage, examining the changes created by the digital medium. It discusses ways of representing text in a digital context, explaining in more detail how to transform textual content from an image form (a scan) into text formats, and ultimately delineates criteria to define quality of digital text relevant for cultural heritage.
4. Conclusion
Authors: Baillot Anne
Published: July 2023

The conclusion reflects on the limits of technologisation for textual heritage. While creating cultural artefacts is destroying natural resources, this chapter argues that as a society, even as a global one, we have been able to build the material and intellectual conditions to provide access to community-building cultural artefacts, especially text. It encourages today's actors to envision a future where access to text is a common good that even more societies can rely on than it is the case today.
Transmediating race and senses through subtitling in translanguaging classroom
Authors: Yoshimizu Ayaka , Hoshi Saori
Published: July 2023

This article reflects on a transdisciplinary curricular project in a Japanese language course that employs audio–visual subtitling to promote students’ critical literacies in languages, cultures, and media. Drawing on Nornes’s (2015) notion of “sensuous subtitling,” which embraces the incorporation of the “materiality of language” into translation, we present how students’ experimental subtitlings potentially make a transformative intervention into how the characters are sensed and felt through film viewing. As Japanese-speaking women teaching Japanese language and culture at an English-speaking university in Canada, we use our bodies as racialized and racializing sites to explore the affective potentials of interlingual subtitles and their pedagogical implications. We reflect on students’ subtitling of Korean Japanese film Where Is the Moon (1993, dir. Yoichi Sai) that embodies race and senses through various cinematic techniques. Students’ subtitlings reshaped the “intercorporeal” space in which the cinematic bodies of the characters touch our bodies (Sekimoto and Brown, 2020).
Exogenous spraying of IAA improved the efficiency of microspore embryogenesis in Wucai (Brassica campestris L.) by affecting the balance of endogenous hormones, energy metabolism, and cell wall degradation
Authors: Wang Chenggang , Zhang Peiyu , He Yun , Huang Furong , Wang Xu , Li Hong , Yuan Lingyun , Hou Jinfeng , Chen Guohu , Wang Wenjie , Wu Jianqiang , Tang Xiaoyan
Published: July 2023

Background

Microspore embryogenesis is an extraordinarily complicated process, comprehensively regulated by a composite network of physiological and molecular factors, among which hormone is one of the most crucial factors. Auxin is required for stress-induced microspore reprogramming, however, the mechanism of its regulation of microspore embryogenesis is still unclear.

Results

In this study, we found exogenously spraying 100 mg·L− 1IAA on the buds of Wucai significantly increased the rate of microspore embryogenesis, and moreover accelerated the process of embryogenesis. Physiological and biochemical tests showed that the contents of amino acids, soluble total sugar, soluble protein, and starch were significantly increased after IAA treatment. Furthermore, exogenously spraying 100 mg·L− 1IAA significantly enhanced IAA, GA4, and GA9content, increased catalase (CAT) and malondialdehyde (MDA) activity, and reduced abscisic acid (ABA), MDA and soluble protopectin content, H2O2and O2·−production rate in the bud with the largest population of late-uninucleate-stage microspores. Transcriptome sequencing was performed on buds respectively treated with 100 mg·L− 1IAA and fresh water. A total of 2004 DEGs were identified, of which 79 were involved in micropores development, embryonic development and cell wall formation and modification, most of which were upregulated. KEGG and GO analysis revealed that 9.52% of DEGs were enriched in plant hormone synthesis and signal transduction pathways, pentose and glucuronic acid exchange pathways, and oxidative phosphorylation pathways.

Conclusions

These findings indicated that exogenous IAA altered the contents of endogenous hormone content, total soluble sugar, amino acid, starch, soluble protein, MDA and protopectin, the activities of CAT and peroxidase (POD), and the production rate of H2O2and O2·−. Combined with transcriptome analysis, it was found that most genes related to gibberellin (GA) and Auxin (IAA) synthesis and signal transduction, pectin methylase (PME) and polygalacturonase (PGs) genes and genes related to ATP synthesis and electron transport chain were upregulated, and genes related to ABA synthesis and signal transduction were downregulated. These results indicated that exogenous IAA treatment could change the balance of endogenous hormones, accelerate cell wall degradation, promote ATP synthesis and nutrient accumulation, inhibit ROS accumulation, which ultimately promote microspore embryogenesis.
Unilateral Osler nodes, Janeway lesions and splinter haemorrhages associated with surgical arterio-venous fistula infection: a case report
Authors: Ruwanpathirana Pramith , Athukorala Harindri , Weeratunga Praveen , Karunanayake Panduka
Published: July 2023

Background

Osler’s nodes, Janeway lesions and splinter haemorrhages are cutaneous manifestations of infective endocarditis. They occur due to vascular occlusion by septic emboli and a resulting localized vasculitis. They are usually bilateral. We report a case of unilateral Osler’s nodes, Janeway lesions and splinter haemorrhages due to an ipsilateral surgical arterio-venous fistula infection.

Case presentation

A fifty-two-year-old Sri Lankan female with end stage kidney disease presented with fever for five days with blurred vision, pain and redness of the right eye. She had a left brachio-cephalic arterio-venous fistula (AVF) created one month back. She complained of a foul-smelling discharge from the surgical site for past three days. Redness of the right eye with a hypopyon was noted. AVF site over the left cubital fossa was infected with a purulent discharge. Osler’s nodes, Janeway lesions and splinter haemorrhages were noted in the distal fingers, thenar and hypothenar eminences of the left hand. Right hand and both feet were normal. No cardiac murmurs were heard. Blood cultures, vitreous sample cultures and pus cultures from the fistula site were all positive for methicillin sensitive Staphylococcus aureus. Infective endocarditis was excluded by a trans-oesophageal echocardiogram. She was treated with IV flucloxacillin and surgical excision of the AVF.

Conclusion

Infections of AVF can result in septic emboli formation which can have both anterograde arterial embolization and retrograde venous embolization. Arterial embolization can result in unilateral Osler’s nodes, Janeway lesions and splinter haemorrhages. Venous embolization can cause metastatic infections in the systemic and pulmonary circulations.
Single-organ pulmonary metastasis is a favorable prognostic factor in metastatic colorectal cancer patients treated with FOLFIRI and vascular endothelial growth factor inhibitors
Authors: Fukuda Koshiro , Osumi Hiroki , Yoshino Koichiro , Nakayama Izuma , Fukuoka Shota , Ogura Mariko , Wakatsuki Takeru , Ooki Akira , Takahari Daisuke , Chin Keisho , Yamaguchi Kensei , Shinozaki Eiji
Published: July 2023

Background

Few studies have focused on the impact of single-organ pulmonary metastases on progression-free survival and overall survival in patients with metastatic colorectal cancer. Recognizing differences in prognosis and chemotherapeutic efficacy based on metastasized organs may help in optimizing treatment strategies. The exploratory study was conducted to evaluate the comparative clinical outcomes and prognoses of patients with metastatic colorectal cancer presenting with single-organ pulmonary metastases and treated with folinic acid, 5-fluorouracil, irinotecan, and vascular endothelial growth factor inhibitors as second-line chemotherapy.

Methods

This retrospective study included 289 patients with metastatic colorectal cancer treated with second-line folinic acid, 5-fluorouracil, irinotecan, and vascular endothelial growth factor inhibitors. The response rate, disease control rate, progression-free survival, and overall survival were assessed in the participants.

Results

Among the 289 patients enrolled, 26 (9.0%) had single-organ pulmonary metastasis with left-sided primary locations, lower levels of tumor markers at the initiation point of chemotherapy, a significantly higher disease control rate (96.2% vs. 76.7%, P = .02), and a longer progression-free survival (median 29.6 months vs. 6.1 months, P < .001) and overall survival (median 41.1 months vs. 18.7 months, P < .001) than patients with other forms of metastatic colorectal cancer. Multivariate analysis showed that single-organ pulmonary metastasis was an independent predictor of longer progression-free survival (hazard ratio 0.35, P = .00075) and overall survival (hazard ratio 0.2, P = .006).

Conclusion

Single-organ pulmonary metastasis was a strong predictor of progression-free survival and overall survival in patients with metastatic colorectal cancer treated with folinic acid, 5-fluorouracil, irinotecan, and vascular endothelial growth factor inhibitors as second-line chemotherapy; this provides preliminary evidence for medical guidelines and clinical decision-making on novel therapeutic strategies for these patients.
Clinical applications of skin traction technique with adjustable tension in treatment of large area skin defects
Authors: Nadaph Md Israil , Meng Chong , Wu Xuejian
Published: July 2023

Objective

To explore the clinical applications of the adjustable skin traction technique in the treatment of large area skin defects.

Research design

A prospective study.

Background

The skin is the largest organ of the human body and skin tissue exposed to external environment which makes it vulnerable to damage. There are many reasons for skin defects such as trauma, infection, burns, scars, tumors resection, inflammation, pigmented nevus, etc. Skin traction is the application of pulling force to the trunk or extremities for immobilization, fracture reduction and deformity correction. This technique accurately controls skin expansion which is safe, convenient and accelerates wound healing.

Methods

A prospective study was conducted on 80 patients suffered from large area skin defects in the department of orthopedics, the first affiliated hospital of Zhengzhou University from September 2019 to January 2023. There were 40 patients in the experimental group who underwent skin traction. In contrast, 40 people in the control group underwent skin flaps or skin grafts without skin traction. The inclusion criteria include large area skin defects, normal peripheral skin & blood supply, normal vital organs, no severe coagulation dysfunction etc. Male & female with and without skin traction are 22 & 18 and 25 & 15 respectively. The skin traction device used was a hook and single rod type. The skin defect area was approximately 15 cm × 9-43 cm × 10 cm.

Results

Postoperatively, the experimental group with traction showed 2 cases of skin infection, 1 case of skin necrosis and 3 cases of inflammation recurrence. In contrast, the control group without traction showed 8 cases of skin infection, 6 cases of skin necrosis and 10 cases of inflammation recurrence. Skin infection (P = 0.04), skin necrosis (P = 0.02) and inflammatory response (P = 0.03) represented significant differences between two groups. There was also a significant difference in hospitalization costs (P = 0.001).

Conclusion

Skin traction has huge clinical applications including a shorter hospital stay, faster wound healing, lower hospitalization cost, high satisfaction rate, and a fair skin appearance after surgery. It is an effective method of treating skin and musculoskeletal defects.
Should Artificial Intelligence be used to support clinical ethical decision-making? A systematic review of reasons
Authors: Benzinger Lasse , Ursin Frank , Balke Wolf-Tilo , Kacprowski Tim , Salloch Sabine
Published: July 2023

Background

Healthcare providers have to make ethically complex clinical decisions which may be a source of stress. Researchers have recently introduced Artificial Intelligence (AI)-based applications to assist in clinical ethical decision-making. However, the use of such tools is controversial. This review aims to provide a comprehensive overview of the reasons given in the academic literature for and against their use.

Methods

PubMed, Web of Science, Philpapers.org and Google Scholar were searched for all relevant publications. The resulting set of publications was title and abstract screened according to defined inclusion and exclusion criteria, resulting in 44 papers whose full texts were analysed using the Kuckartz method of qualitative text analysis.

Results

Artificial Intelligence might increase patient autonomy by improving the accuracy of predictions and allowing patients to receive their preferred treatment. It is thought to increase beneficence by providing reliable information, thereby, supporting surrogate decision-making. Some authors fear that reducing ethical decision-making to statistical correlations may limit autonomy. Others argue that AI may not be able to replicate the process of ethical deliberation because it lacks human characteristics. Concerns have been raised about issues of justice, as AI may replicate existing biases in the decision-making process.

Conclusions

The prospective benefits of using AI in clinical ethical decision-making are manifold, but its development and use should be undertaken carefully to avoid ethical pitfalls. Several issues that are central to the discussion of Clinical Decision Support Systems, such as justice, explicability or human–machine interaction, have been neglected in the debate on AI for clinical ethics so far.

Trial registration

This review is registered at Open Science Framework (https://osf.io/wvcs9).
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy
Authors: Bao Jianhang , Gao Wenshuo , Zhang Wei , Wang Dong , Pan Hao
Published: July 2023

Purpose

To construct an injectable, sustained-release fibrin gel containing rhein to solve the problem of low bioavailability of rhein, and observe its efficacy in the treatment of intervertebral disc degeneration.

Methods

The fibrin gel containing rhein was first synthesized in advance. Subsequently, the materials were characterized by various experimental methods. Secondly, the degenerative cell model was constructed by stimulating nucleus pulposus cells with lipopolysaccharide (LPS), and the corresponding intervention treatment was carried out to observe the effect in vitro. Finally, the rat tail intervertebral disc was acupunctured by needles to establish the intervertebral disc degeneration model, and the effect of the material was observed through intradiscal injection.

Results

The fibrin glue containing rhein (rhein@FG) showed good injectability, sustained release and biocompatibility. Rhein@FG can improve the LPS-induced inflammatory microenvironment, regulate ECM metabolic disorders of nucleus pulposus cells and aggregation of the NLRP3 inflammasome in vitro, and inhibit cell pyroptosis. Furthermore, in vivo experiments, rhein@FG effectively prevented needle puncture-induced intervertebral disc degeneration in rats.

Conclusions

Rhein@FG has better efficacy than rhein or FG alone due to its slow release and mechanical properties, which can be used as a potential replacement therapy for intervertebral disc degeneration.

Graphical Abstract
What is the difference in proprioception between single condylar arthroplasty and high tibial osteotomy? a comparative study on both knees of the same patient
Authors: Ge Hao , Huang Yiwei , Yan Hongsong , Zeng Yirong , Zeng Jianchun
Published: July 2023

Objective

This study aims to investigate the efficacy and outcomes of different surgical procedures, namely unicompartmental knee arthroplasty (UKA) and high tibial osteotomy (HTO), for the treatment of bilateral medial compartment knee osteoarthritis in the same patient. The joint awareness and function of these two surgical methods were evaluated.

Methods

A total of 15 patients with bilateral medial compartment knee osteoarthritis who underwent either UKA or HTO between 2012 and 2020 were included in the study. Patient data, including age, gender, body mass index and length of hospital stay, were collected. Pre- and post-operative measurements were conducted, including tibiofemoral angle, tibial plateau posterior inclination angle, proximal tibial medial angle, distance from mechanical axis to knee joint center, hip-knee-ankle angle, pre- and post-operative knee joint scores, knee joint range of motion, and FIS-12 scores at 3, 6, 12, and 24 months postoperatively. The latest follow-up was used for evaluating the outcomes of osteoarthritis treatment. Normality of continuous variables was assessed using the Shapiro–Wilk test. Between-group comparisons were performed using the paired sample t-test or Wilcoxon rank-sum test. Repeated measures analysis of variance was utilized to analyze FJS-12 measurements at different time points, and the correlation between FJS-12 and postoperative clinical results was examined using Pearson's correlation coefficient. Statistical significance was set at P < 0.05.

Results

Significant differences were observed in FJS between the UKA and HTO groups at 3 and 6 months postoperatively, but no significant difference was found at 1 and 2 years postoperatively. FJS in the UKA group demonstrated a significant increase from 3 to 6 months postoperatively, but no significant difference was observed from 6 to 24 months postoperatively. In contrast, FJS in the HTO group showed a significant increase from 3 to 24 months postoperatively.

Conclusions

Patients who underwent UKA exhibited superior joint awareness compared to those who underwent HTO during the early postoperative period. Furthermore, the rate of joint awareness in UKA patients was faster than in HTO patients.