bluuebunny/crossref_metadata_2025 huggingface dataset:
Pins and Rubber Band Traction System Combined with Internal Fixation for Intra-articular Fractures of the Proximal Interphalangeal Joints
Authors: MORISAKI Shinsuke , TSUCHIDA Shinji , ODA Ryo , TAKAHASHI Kenji
Published: July 2024

Background: Intra-articular fractures of the proximal interphalangeal joint (PIPJ) can result in poor outcomes if inadequately treated. Dynamic external fixation and internal fixation with plates and/or screws are two treatment options. The role of combining these two methods is unclear. The aim of this study is to determine the outcomes of patients with intra-articular fractures of the PIPJ treated with a combination of dynamic external fixation with a plate and/or screws.

Methods: A retrospective review was conducted on 18 consecutive cases of intra-articular fractures of the PIPJ treated with pins and rubber band traction system (PRTS) combined with dorsal internal fixation with plates and/or screws. The patients’ average age was 51 years (range: 20–81 years). The fracture patterns were volar-type (n = 2), dorsal-type (n = 4) and pilon-type (n = 12). Data with regard to time to surgery, interphalangeal joint range of motion, grip strength, VAS for pain, Quick DASH score, complications, duration of follow-up and return to work were collected.

Results: The levels of articular involvement were stable (n = 1), tenuous (n = 5) and unstable (n = 12). The average time to surgery was 9 days, and the average follow-up period was 15 months. The fracture was fixed with a dorsal plate and screws in 10 patients and with only screws in eight patients. All patients had PRTS. All patients returned to their original occupation and the fractures united in good alignment. The average grip strength was 86% of that of the unaffected side. The average active PIPJ motion was 85° (range: 50°–106°), and the average active distal interphalangeal joint (DIPJ) motion was 48° (range: 10°–90°).

Conclusions: Our results show that a combination of PRTS and open reduction and fixation with plate and/or screws achieved a good range of motion and articular reduction.

Level of Evidence: Level IV (Therapeutic)
Post-surgical Rehabilitation Guidelines for Triangular Fibrocartilage Complex Foveal Repair: A Survey of Australian Hand and Wrist Surgeons
Authors: MCCARRON Luke , COOMBES Brooke K. , BINDRA Randy , BISSET Leanne
Published: July 2024

Background: To restore distal radioulnar joint stability following injury to the Triangular Fibrocartilage Complex (TFCC), foveal repair surgery may be necessary. Post-surgery rehabilitation is prescribed to restore wrist and hand function; however, no universally accepted or definitive rehabilitation protocol currently exists. The aim of this study was to survey hand and wrist surgeons regarding their recommended postoperative rehabilitation protocols following TFCC foveal repair surgery.

Methods: Australian hand and wrist surgeons were invited to complete a descriptive survey containing 10 questions. Questions included clinical recommendations for wrist and forearm immobilisation, range of motion (ROM) exercise timeframes and surgeon experience of TFCC rupture. Descriptive statistics and between-group (TFCC rupture vs. no-rupture) comparisons (Pearson’s Chi2) were calculated.

Results: Thirty-one surgeons completed the survey. Recommendations for post-surgery immobilisation ranged from ‘not required’ to 8 weeks (mode 6 weeks). Wrist and forearm ROM commencement time ranged from ‘immediately’ to ‘later than 8 weeks’ (mode 6 weeks). The most recommended orthosis was a ‘sugar-tong’ (57%). Thirty-seven percent (37%) reported experience of post-surgery re-rupture.

Conclusions: While surgeon recommendations varied, the majority recommended 4- to 6-week timeframe for immobilisation and ROM exercise commencement. Additional clinical research is recommended to evaluate whether postoperative rehabilitation decisions influence patient outcomes.

Level of Evidence: Level V (Therapeutic)
Posterolateral Locked Plate and Percutaneous Medial Screw Fixation for Distal Humerus Fractures in Elderly
Authors: KUWAHARA Yutaro , HARA Tatsuya , KURAHASHI Toshikazu , TATEBE Masahiro
Published: July 2024

Background: A high incidence of ulnar nerve-related complications has been reported in open reduction and internal fixation for distal humerus fractures (DHFs). To minimise ulnar nerve damage, we used a percutaneous medial screw combined with a posterolateral plate in the elderly. The aim of this study was to evaluate the postoperative complications and functional outcomes of this method.

Methods: Data from patients aged over 65 who underwent this surgical procedure for DHFs at a single Level I trauma centre from 2013 to 2021 were extracted. Postoperative complications, reoperations, mean range of motion, Mayo Elbow Performance Index (MEPI) scores and Hand20 scores were retrospectively evaluated. All patients in this study received postoperative rehabilitation by hand therapists at our hospital.

Results: We identified 28 patients treated with this method. The mean follow-up period was 8.6 ± 3.7 months. The median intraoperative time was 125 minutes (interquartile range: 105–157 minutes). None of the patients developed ulnar nerve neuropathy, but one patient (3.7%) experienced radial nerve dysfunction. Two patients (7.4%) had nonunion. Implant failure occurred in three patients (11.1%) due to migration of the medial screw. One patient (3.7%) amongst them underwent reoperation. The mean flexion to extension arc was 97 ± 18°, 116 ± 19°, and 116 ± 19° at 1-, 3- and 6-month follow-ups, respectively. According to the MEPI, 20 patients achieved excellent results, seven patients achieved good results and one patient achieved a fair result at the last follow-up. The median Hand20 score was 4.3 (interquartile range: 2.1–14.0) at the 6-month follow-up.

Conclusions: The posterolateral plate and medial screw method showed good functional outcomes and few nerve-related complications. This modified method might be a better option for DHFs in elderly patients.

Level of Evidence: Level IV (Therapeutic)
ReN Human: Learning Relightable Neural Implicit Surfaces for Animatable Human Rendering
Authors: Xie Rengan , Huang Kai , Cho In-Young , Yang Sen , Chen Wei , Bao Hujun , Zheng Wenting , Li Rong , Huo Yuchi
Published: July 2024

Recently, implicit neural representation has been widely used to learn the appearance of human bodies in the canonical space, which can be further animated using a parametric human model. However, how to decompose the material properties from the implicit representation for relighting has not yet been investigated thoroughly. We propose to address this problem with a novel framework, ReN Human, that takes sparse or even monocular input videos collected in unconstrained lighting to produce a 3D human representation that can be rendered with novel views, poses, and lighting. Our method represents humans as deformable implicit neural representation and decomposes the geometry, material of humans as well as environment illumination for capturing a relightable and animatable human model. Moreover, we introduce a volumetric lighting grid consisting of spherical Gaussian mixtures to learn the spatially varying illumination and animatable visibility probes to model the dynamic self-occlusion caused by human motion. Specifically, we learn the material property fields and illumination using a physically-based rendering layer that uses Monte Carlo importance sampling to facilitate differentiation of the complex rendering integral. We demonstrate that our approach outperforms recent novel views and poses synthesis methods in a challenging benchmark with sparse videos, enabling high-fidelity human relighting.
Cross-Blockchain Communication Using Oracles With an Off-Chain Aggregation Mechanism Based on zk-SNARKs
Authors: Sober Michael , Scaffino Giulia , Schulte Stefan
Published: July 2024

The closed architecture of prevailing blockchain systems renders the usage of this technology mostly infeasible for a wide range of real-world problems. Most blockchains trap users and applications in their isolated space without the possibility of cooperating or switching to other blockchains. Therefore, blockchains need additional mechanisms for seamless communication and arbitrary data exchange between each other and external systems. Unfortunately, current approaches for cross-blockchain communication are resource-intensive or require additional blockchains or tailored solutions depending on the applied consensus mechanisms of the connected blockchains. Therefore, we propose an oracle with an off-chain aggregation mechanism based on Zero-Knowledge Succinct Non-interactive Arguments of Knowledge (zk-SNARKs) to facilitate cross-blockchain communication. The oracle queries data from another blockchain and applies a rollup-like mechanism to move state and computation off-chain. The
zkOracle
contract only expects the transferred data, an updated state root, and proof of the correct execution of the aggregation mechanism. The proposed solution only requires constant 378 kgas to submit data on the Ethereum blockchain and is primarily independent of the underlying technology of the queried blockchains.
Refusal (and Repair)
Authors: Thomas Deborah A.
Published: July 2024

This article focuses on the concept of refusal, particularly as it has been developed within critical Black studies and critical Indigenous studies within anthropology and beyond. It argues that while both Foucauldian and Gramscian frames have generated often exquisite analyses of the animations and counter-animations of power, they have not, in a general sense, sufficiently attended to the foundational processes that charted the possibilities of modern personhood and political life not only in the West but globally. Nor did they tend to acknowledge the genealogies of Black and Indigenous radical thought that were informing approaches to political life within these communities, locally and transnationally. I contend that any significant reformulation of the discipline of anthropology must deliberate anew about the logics and mechanisms of political struggle in a way that recognizes and foregrounds—in nuanced and dynamic ways—the ongoing coloniality and racism that constitute the afterlives (and still lives) of conquest. Refusal provides inroads to this project.
Predictability in Language Comprehension: Prospects and Problems for Surprisal
Authors: Staub Adrian
Published: July 2024

Surprisal theory proposes that a word's predictability influences processing difficulty because each word requires the comprehender to update a probability distribution over possible sentences. This article first considers the theory's detailed predictions regarding the effects of predictability on reading time and N400 amplitude. Two rather unintuitive predictions appear to be correct based on the current evidence: There is no specific cost when an unpredictable word is encountered in a context where another word is predictable, and the function relating predictability to processing difficulty is logarithmic, not linear. Next, the article addresses the viability of the claim, also associated with Surprisal, that conditional probability is the “causal bottleneck” mediating all effects on incremental processing difficulty. This claim fares less well as conditional probability does not account for the difficulty associated with encountering a low-frequency word or the difficulty associated with garden path disambiguation. Surprisal provides a compelling account of predictability effects but does not provide a complete account of incremental processing difficulty.
Significant Improvements to Si Calendar Lifetime Using Rapid Electrolyte Screening via Potentiostatic Holds
Authors: Verma Ankit , Schulze Maxwell C. , Colclasure Andrew , Rodrigues Marco-Tulio Fonseca , Trask Stephen E. , Pupek Krzysztof , Abraham Daniel P.
Published: July 2024

Silicon-based lithium-ion batteries exhibit severe time-based degradation resulting in poor calendar lives. This has been identified as the major impediment towards commercialization with cycle life considered a solved issue through nanosizing and protective coatings allowing over 1000 cycles of life to be achieved. In this work, rapid screening of sixteen electrolytes for calendar life extension of Si-rich systems (70 wt% Si) is performed using the voltage hold (V-hold) protocol. V-hold significantly shortens the testing duration over the traditional open circuit voltage reference performance test allowing us to screen electrolytes within a span of two months. We find a novel ethylene carbonate (EC) free electrolyte formulation containing lithium hexafluorophosphate (LiPF6) salt, and binary solvent mix of fluoroethylene carbonate (FEC), ethyl methyl carbonate (EMC) that extends calendar life of Si cells as compared to conventional EC based electrolyte. Our coupled experimental-theoretical analysis framework provides a decoupling of the parasitic currents during V-hold, allowing us to extrapolate the capacity loss to predict semiquantitative calendar lifetimes. Subsequently, cycle aging and oxidative stability tests of the EC free system also show enhanced performance over baseline electrolyte.
Long‐Term Outcomes of Phacoemulsification Surgeries at ECWA Eye Hospital: A Prospective Clinical Cohort Study
Authors: Atima Mayor Orezime , Idakwo Ugbede , Komolafe Oyeronke , Shimizu Eisuke , Shintaro Nakayama , Balogun Emmanuel Oluwadare , Dingwoke Emeka John , Orugun Ayodele Jacob , Ogundare Olalekan Adebayo , Jah Pam Douglas
Published: July 2024

Background. Phacoemulsification has proven to be a breakthrough technique in cataract surgery. Its popularity has grown dramatically as procedures and equipment have advanced, improving both safety and efficiency. This study presents long‐term outcomes from phacoemulsification surgeries performed at the Evangelical Church Winning All (ECWA) Eye Hospital, a tertiary eye care center. Method. This prospective clinical cohort study followed standard practices for operations performed under local anesthesia. Ophthalmologists evaluated long‐term outcomes and predictors of improved visual acuity after phacoemulsification cataract surgery. The visual recovery of the patients over time was evaluated, and the factors that influence the gains in vision were identified. Results. A total of 177 patients were subjected to treatment at our facilities during the study period. There were 116 male and 61 female patients, which resulted to a male‐to‐female ratio of 1 : 0.53. The average age of the patients was 59.18 years with a standard deviation of 11.38 years. Of the 259 eyes treated, 249 eyes (96.1%) achieved a high success rate with visual acuity of 6/6 – 6/18. Ten (10) eyes (3.9%) had moderate acuity between <6/18 and 6/60. Follow‐up examinations over five years after phacoemulsification showed poor vision outcomes among old patients. The primary factor that affected improvement in visual acuity among patients was amblyopia, present in 30% of cases. Posterior capsular opacification and macular edema collectively accounted for 20% of poor vision cases, while optic atrophy, glaucoma, and retinal hemorrhage each represented approximately 10% of poor vision cases. Conclusions. The phacoemulsification approach demonstrated a highly effective restoration of vision for the vast majority, while long‐term data analysis indicated the potential for age‐related variability in postoperative visual gains.
An NLP‐Based Framework to Spot Extremist Networks in Social Media
Authors: Zapata Rozo Andrés , Díaz-López Daniel , Pastor-Galindo Javier , Gómez Mármol Félix , Karabiyik Umit
Published: July 2024

Governments and law enforcement agencies (LEAs) are increasingly concerned about growing illicit activities in cyberspace, such as cybercrimes, cyberespionage, cyberterrorism, and cyberwarfare. In the particular context of cyberterrorism, hostile social manipulation (HSM) represents a strategy that employs different manipulation methods, mostly through social media, to promote extremism in social groups and encourage hostile behavior against a target. Thus, this paper proposes a framework based on natural language processing (NLP) that detects and inspects supposed HSM actions to support law enforcement agencies (LEAs) in the prevention of cyberterrorism. The proposal integrates different NLP techniques through three models: (i) a similarity model that relates content with similar semantic meaning, (ii) a polarity analysis model that estimates polarity, and (iii) a named‐entity recognition (NER) model that recognizes relevant entities. In addition, our proposed framework is evaluated in each of its components through exhaustive experiments and is tested with a particular use case related to violent protests in Ecuador in October 2021. Use case’s results indicate that 3 and 4 clusters are obtained when Spanish and English‐translated tweets are used, respectively. An analysis of polarity over English‐translated tweets allows us to identify, through two different methods, the most negative cluster (#1). The results of the extraction of the mentions show that our framework is able to identify entities of the type of person that may be at risk with a precision of 89.91%. Knowledge graphs achieved in our use case allow us to identify how nodes that promote HSM are interconnected and work collaboratively. Finally, the computational costs of our proposal are quite favorable as memory consumption of similarity and polarity models is proportional to the number of processed tweets, confirming the feasibility of the solution in a real context.
The Effects of Desiccation on the Antioxidant Defense, Immune Responses, and Nitrogen Metabolism of Red Swamp Crayfish Procambarus clarkii
Authors: Ding Shuquan , Chi Haomiao , You Kun , Huang Mei , Wu Mengxiao , Zhang Linjiang , Cui Xingyan , Xu Ran , Zhang Yunlong
Published: July 2024

Desiccation due to air exposure is a common environmental stress that harms the health of crustaceans. How crustaceans respond to air exposure remains largely unclear. In this research, we explored the physiological responses and gene regulation under air exposure of an invasive species Procambarus clarkii, which is the most commonly cultured freshwater crustacean in China. Toll3 belonging to the Toll‐like receptor family and proPO in the prophenoloxidase‐activating system were two important immune responses to air exposure. In addition, air exposure can also influence ammonia metabolism via regulating the expression of the key genes. Prx6 and proPO showed quick responses and high sensitivity to air exposure, suggesting the potential to be the biomarker for desiccation stress assessment in crayfish. The results of this research can provide useful information for monitoring desiccation stress, as well as transport and sale management in red swamp crayfish.
Some Boundedness, Convergence, and Oscillatory Results of Generalized Fibonacci‐Type and Fibonacci Ratio Recurrences
Authors: De la Sen Manuel
Published: July 2024

Some boundedness and convergence properties of generalized Fibonacci’s‐type recurrences and their associated iterated recurrence ratios between pairs of consecutive terms are discussed under a wide number of initial conditions. Also, a more general, so‐called (k,q) Fibonacci’s recurrence and the associated Fibonacci’s ratio recurrences are investigated, where the constantskandqare the prefixed gains used to generate each new member of the recurrences from the two preceding ones. Some oscillation and periodicity conditions are also discussed depending on the initial conditions, while convergence and stability properties are also dealt with. The initial conditions of the recurrences can be fixed arbitrarily, so that both the well‐known standard Fibonacci recurrence and the Lucas recurrence are just particular cases. In the most general case, the initial conditions can be integer or real and of alternate signs. Later on, the manuscript deals with some further boundedness, oscillation, convergence, and stability properties of generalized Fibonacci recurrences and associated Fibonacci ratio recurrences being generated under, in general, recurrence‐dependent gain sequences.
Numerical Investigation of Entropy Generation on Micropolar Trihybrid Nanofluid Flow with Blood as Base Fluid in a Channel
Authors: Mehmood Yasir , Alsinai Ammar , Bilal Muhammad , Iqbal Saleha , Khan Niazi Azmat Ullah , Faisal Nujood
Published: July 2024

This research paper focuses on investigating the phenomenon of entropy generation, specifically within the context of blood flow. Blood is modeled as a three‐layered liquid model, with micropolar and Newtonian fluids occupying the center and periphery sections of the tube, respectively. A narrow glycocalyx layer adjacent to the wall is regarded as indicating a permeable area caused by the accumulation of carbohydrates and fibrous tissues within the tube wall. Further, the walls of the cylinder are taken as permeable. The objectives of this study include understanding the mechanisms and factors contributing to entropy generation in blood patterns, exploring the relationship between entropy generation and flow characteristics, and analyzing the impact of entropy generation on the overall energy efficiency of the system. The transformation of ordinary differential equations (ODEs) from partial differential equations (PDEs) can be accomplished by employing a similarity approach that combines shooting methods with the inculcation of the RK‐4 method. This integrated technique facilitates the transformation process effectively. Then, MATLAB software is used to plot graphs for accuracy purposes. Under various physical limitations, the comparison study demonstrates that trihybrid nanoliquids exhibit ultrahigh thermal efficiency compared to ordinary nanoliquids, and incorporating these nanofluids enhances entropy generation, temperature, and Bejan profiles, improving thermal conductivity and energy transfer. This integration ensures sustained performance over time, benefiting from carefully selected nanoparticles for stability optimization. As a result, these fluids are extremely useful for industrial applications, particularly filtration and ultrahigh heat.
Supplementary Figure 6 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer
Authors: Boumelha Jesse , de Castro Andrea , Bah Nourdine , Cha Hongui , de Carné Trécesson Sophie , Rana Sareena , Tomaschko Mona , Anastasiou Panayiotis , Mugarza Edurne , Moore Christopher , Goldstone Robert , East Phil , Litchfield Kevin , Lee Se-Hoon , Molina-Arcas Miriam , Downward Julian
Published: July 2024

Supplementary Figure 6. Tumor-intrinsic COX-2 remodels the lung tumor microenvironment
Fig. S5 from Metabolic Reprogramming Is an Initial Step in Pancreatic Carcinogenesis That Can Be Targeted to Inhibit Acinar-to-Ductal Metaplasia
Authors: Neuß Thorsten , Chen Min-Chun , Wirges Nils , Usluer Sinem , Oellinger Rupert , Lier Svenja , Dudek Michael , Madl Tobias , Jastroch Martin , Steiger Katja , Schmitz Werner , Einwächter Henrik , Schmid Roland M.
Published: July 2024

Brightfield images of isolated and treated acinar cells from mice and humans
Figure 3 from CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer
Authors: Boumelha Jesse , de Castro Andrea , Bah Nourdine , Cha Hongui , de Carné Trécesson Sophie , Rana Sareena , Tomaschko Mona , Anastasiou Panayiotis , Mugarza Edurne , Moore Christopher , Goldstone Robert , East Phil , Litchfield Kevin , Lee Se-Hoon , Molina-Arcas Miriam , Downward Julian
Published: July 2024

COX2/PGE2 signaling hinders response to ICB in mouse and human lung adenocarcinoma. A, Kaplan–Meier survival of mice treated intraperitoneally with 200 μg anti-PD1 after orthotopic transplantation of KPAR or Ptgs2−/− cells, n = 6–8 per group. Analysis of survival curves was carried out using the log-rank (Mantel–Cox) test. B, Quantification and representative IHC staining of CD8+ T cells in KPAR or Ptgs2−/− orthotopic tumors on day 7 after treatment with anti-PD1 or corresponding isotype control (IgG). Scale bar, 100 μm. C, Percentage of CD69+ CD8+ T cells in KPAR or Ptgs2−/− tumors treated as shown in B. D, Frequency of PD1+, LAG3+, and TIM3+ CD8+ T cells in KPAR or Ptgs2−/− tumors treated as shown in B. E, Heatmap showing hierarchical clustering of KPAR or Ptgs2−/− tumors treated as shown in B based on mRNA expression of antitumor immunity genes assessed by qPCR. F, Baseline COX-IS levels in responder (R) and nonresponder (NR) ICB-treated patients with lung adenocarcinoma. G, Progression-free survival of patients with lung adenocarcinoma treated with ICB, stratified into highest and lowest quartile based on COX-IS expression. H, Multivariate Cox regression analysis for the indicated variables in patients with lung adenocarcinoma following ICB treatment. CTx, chemotherapy. Error bars represent 95% confidence interval (CI) boundaries. Data are represented as mean ± SEM for B–D, n = 5–9 per group. Statistics were calculated using two-tailed Student t test (F) or one-way ANOVA, FDR 0.05 (B–D). ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
Supplementary Data from IL1R2 Blockade Alleviates Immunosuppression and Potentiates Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Authors: Xia Jie , Zhang Lixing , Peng Xilei , Tu Juchuanli , Li Siqin , He Xueyan , Li Fengkai , Qiang Jiankun , Dong Haonan , Deng Qiaodan , Liu Cuicui , Xu Jiahui , Zhang Rui , Liu Quentin , Hu Guohong , Liu Chong , Jiang Yi-Zhou , Shao Zhi-Ming , Chen Ceshi , Liu Suling
Published: July 2024

Table S2
Supplementary Data from IL1R2 Blockade Alleviates Immunosuppression and Potentiates Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Authors: Xia Jie , Zhang Lixing , Peng Xilei , Tu Juchuanli , Li Siqin , He Xueyan , Li Fengkai , Qiang Jiankun , Dong Haonan , Deng Qiaodan , Liu Cuicui , Xu Jiahui , Zhang Rui , Liu Quentin , Hu Guohong , Liu Chong , Jiang Yi-Zhou , Shao Zhi-Ming , Chen Ceshi , Liu Suling
Published: July 2024

Table S3
Table S1 from ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs
Authors: Sicinska Ewa , Kola Vijaya S.R. , Kerfoot Joseph A. , Taddei Madeleine L. , Al-Ibraheemi Alyaa , Hsieh Yi-Hsuan , Church Alanna J. , Landesman-Bollag Esther , Landesman Yosef , Hemming Matthew L.
Published: July 2024

Table S1. Oligonucleotide sequences.
Figure S19 from ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs
Authors: Sicinska Ewa , Kola Vijaya S.R. , Kerfoot Joseph A. , Taddei Madeleine L. , Al-Ibraheemi Alyaa , Hsieh Yi-Hsuan , Church Alanna J. , Landesman-Bollag Esther , Landesman Yosef , Hemming Matthew L.
Published: July 2024

Figure S19. Effects of palbociclib and sunitinib in ASPS
Figure S16 from ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs
Authors: Sicinska Ewa , Kola Vijaya S.R. , Kerfoot Joseph A. , Taddei Madeleine L. , Al-Ibraheemi Alyaa , Hsieh Yi-Hsuan , Church Alanna J. , Landesman-Bollag Esther , Landesman Yosef , Hemming Matthew L.
Published: July 2024

Figure S16. Expression of ASPS-associated genes in TFE3-translocated tumors and transfected cell lines.
Figure S15 from ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs
Authors: Sicinska Ewa , Kola Vijaya S.R. , Kerfoot Joseph A. , Taddei Madeleine L. , Al-Ibraheemi Alyaa , Hsieh Yi-Hsuan , Church Alanna J. , Landesman-Bollag Esther , Landesman Yosef , Hemming Matthew L.
Published: July 2024

Figure S15. Expression of ASPS-associated genes in GTEx.
Figure S6 from ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis
Authors: Shrestha Raj K. , Nassar Zeyad D. , Hanson Adrienne R. , Iggo Richard , Townley Scott L. , Dehairs Jonas , Mah Chui Y. , Helm Madison , Alizadeh-Ghodsi Mohammadreza , Pickering Marie , Ghesquière Bart , Watt Matthew J. , Quek Lake-Ee , Hoy Andrew J. , Tilley Wayne D. , Swinnen Johannes V. , Butler Lisa M. , Selth Luke A.
Published: July 2024

Effect of ACSM1 or ACSM3 overexpression on prostate cancer growth.
Dataset S1 from ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis
Authors: Shrestha Raj K. , Nassar Zeyad D. , Hanson Adrienne R. , Iggo Richard , Townley Scott L. , Dehairs Jonas , Mah Chui Y. , Helm Madison , Alizadeh-Ghodsi Mohammadreza , Pickering Marie , Ghesquière Bart , Watt Matthew J. , Quek Lake-Ee , Hoy Andrew J. , Tilley Wayne D. , Swinnen Johannes V. , Butler Lisa M. , Selth Luke A.
Published: July 2024

Quantification of fatty acids by mass spectrometry
Data from Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer
Authors: Sussman Jonathan H. , Kim Nathalia , Kemp Samantha B. , Traum Daniel , Katsuda Takeshi , Kahn Benjamin M. , Xu Jason , Kim Il-Kyu , Eskandarian Cody , Delman Devora , Beatty Gregory L. , Kaestner Klaus H. , Simpson Amber L. , Stanger Ben Z.
Published: July 2024

Abstract
Oncogenesis and progression of pancreatic ductal adenocarcinoma (PDAC) are driven by complex interactions between the neoplastic component and the tumor microenvironment, which includes immune, stromal, and parenchymal cells. In particular, most PDACs are characterized by a hypovascular and hypoxic environment that alters tumor cell behavior and limits the efficacy of chemotherapy and immunotherapy. Characterization of the spatial features of the vascular niche could advance our understanding of inter- and intratumoral heterogeneity in PDAC. In this study, we investigated the vascular microenvironment of PDAC by applying imaging mass cytometry using a 26-antibody panel on 35 regions of interest across 9 patients, capturing more than 140,000 single cells. The approach distinguished major cell types, including multiple populations of lymphoid and myeloid cells, endocrine cells, ductal cells, stromal cells, and endothelial cells. Evaluation of cellular neighborhoods identified 10 distinct spatial domains, including multiple immune and tumor-enriched environments as well as the vascular niche. Focused analysis revealed differential interactions between immune populations and the vasculature and identified distinct spatial domains wherein tumor cell proliferation occurs. Importantly, the vascular niche was closely associated with a population of CD44-expressing macrophages enriched for a proangiogenic gene signature. Taken together, this study provides insights into the spatial heterogeneity of PDAC and suggests a role for CD44-expressing macrophages in shaping the vascular niche.

Significance: Imaging mass cytometry revealed that pancreatic ductal cancers are composed of 10 distinct cellular neighborhoods, including a vascular niche enriched for macrophages expressing high levels of CD44 and a proangiogenic gene signature.
Data from A Virus-Inspired Inhalable Liponanogel Induces Potent Antitumor Immunity and Regression in Metastatic Lung Tumors
Authors: Li Junyao , Luo Lanqing , He Jia , Yu Jinchao , Li Xinyan , Shen Xueying , Zhang Junxia , Li Sai , Karp Jeffrey M. , Kuai Rui
Published: July 2024

Abstract
Pulmonary delivery of immunostimulatory agents such as poly(I:C) to activate double-stranded RNA sensors MDA5 and RIG-I within lung-resident antigen-presenting cells is a potential strategy to enhance antitumor immunity by promoting type I interferon secretion. Nevertheless, following pulmonary delivery, poly(I:C) suffers from rapid degradation and poor endosomal escape, thus limiting its potency. Inspired by the structure of a virus that utilizes internal viral proteins to tune the loading and cytosolic delivery of viral nucleic acids, we developed a liponanogel (LNG)–based platform to overcome the delivery challenges of poly(I:C). The LNG comprised an anionic polymer hyaluronic acid–based nanogel core coated by a lipid shell, which served as a protective layer to stabilize the nanogel core in the lungs. The nanogel core was protonated within acidic endosomes to enhance the endosomal membrane permeability and cytosolic delivery of poly(I:C). After pulmonary delivery, LNG-poly(I:C) induced 13.7-fold more IFNβ than poly(I:C) alone and two-fold more than poly(I:C) loaded in the state-of-art lipid nanoparticles [LNP-poly(I:C)]. Additionally, LNG-poly(I:C) induced more potent CD8+ T-cell immunity and stronger therapeutic effects than LNP-poly(I:C). The combination of LNG-poly(I:C) and PD-L1 targeting led to regression of established lung metastases. Due to the ease of manufacturing and the high biocompatibility of LNG, pulmonary delivery of LNG may be broadly applicable to the treatment of different lung tumors and may spur the development of innovative strategies for cancer immunotherapy.

Significance: Pulmonary delivery of poly(I:C) with a virus-inspired inhalable liponanogel strongly activates cytosolic MDA5 and RIG-I and stimulates antitumor immunity, representing a promising strategy for safe and effective treatment of metastatic lung tumors.
Supplementary Table S3 from Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment
Authors: Parikh Aparna R. , Chee Bryant H. , Tsai Jill , Rich Thereasa A. , Price Kristin S. , Patel Sonia A. , Zhang Li , Ibrahim Faaiz , Esquivel Mikaela , Van Seventer Emily E. , Jarnagin Joy X. , Raymond Victoria M. , Corvera Carlos U. , Hirose Kenzo , Nakakura Eric K. , Corcoran Ryan B. , Van Loon Katherine , Atreya Chloe E.
Published: July 2024

Supplementary Table S3. Univariate analysis by pre-operative ctDNA status. Depicted are multiple clinicopathologic variables analyzed by ctDNA status.
Supplementary Figure S1 from Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment
Authors: Parikh Aparna R. , Chee Bryant H. , Tsai Jill , Rich Thereasa A. , Price Kristin S. , Patel Sonia A. , Zhang Li , Ibrahim Faaiz , Esquivel Mikaela , Van Seventer Emily E. , Jarnagin Joy X. , Raymond Victoria M. , Corvera Carlos U. , Hirose Kenzo , Nakakura Eric K. , Corcoran Ryan B. , Van Loon Katherine , Atreya Chloe E.
Published: July 2024

Supplementary Figure S1. Schema of ctDNA sampling.
Supplementary Table S4 from Biomarker Identification and Risk Prediction Model Development for Differentiated Thyroid Carcinoma Lung Metastasis Based on Primary Lesion Proteomics
Authors: Peng Xiaoqi , Zhao Hongbo , Ye Lijuan , Hou Fei , Yi Zihan , Ren Yanxin , Lu Lin , Chen Fukun , Lv Juan , Wang Yinghui , Cai Haolin , Zheng Xihua , Yang Qing , Chen Ting
Published: July 2024

Table S4. Semi-quantitative analysis method for IHC
Supplementary Table S4 from Plasma Metabolic Profiles-Based Prediction of Induction Chemotherapy Efficacy in Nasopharyngeal Carcinoma: Results of a Bidirectional Clinical Trial
Authors: Tang Tingxi , Zhou Zhenhua , Chen Min , Li Nan , Sun Jianda , Chen Zekai , Xiao Ting , Wang Xiaoqing , Zhang Longshan , Wang Yingqiao , Zhang Hanbin , Zheng Xiuting , Chen Bei , Ye Feng , Guan Jian
Published: July 2024

Supplementary Table S4. Baseline characteristics of patients in discovery cohort
Supplementary Table S3 from Plasma Metabolic Profiles-Based Prediction of Induction Chemotherapy Efficacy in Nasopharyngeal Carcinoma: Results of a Bidirectional Clinical Trial
Authors: Tang Tingxi , Zhou Zhenhua , Chen Min , Li Nan , Sun Jianda , Chen Zekai , Xiao Ting , Wang Xiaoqing , Zhang Longshan , Wang Yingqiao , Zhang Hanbin , Zheng Xiuting , Chen Bei , Ye Feng , Guan Jian
Published: July 2024

Supplementary Table S3. Representativeness of Study Participants
Supplementary Figure S1 from Plasma Metabolic Profiles-Based Prediction of Induction Chemotherapy Efficacy in Nasopharyngeal Carcinoma: Results of a Bidirectional Clinical Trial
Authors: Tang Tingxi , Zhou Zhenhua , Chen Min , Li Nan , Sun Jianda , Chen Zekai , Xiao Ting , Wang Xiaoqing , Zhang Longshan , Wang Yingqiao , Zhang Hanbin , Zheng Xiuting , Chen Bei , Ye Feng , Guan Jian
Published: July 2024

Supplementary Figure S1. Diagram of Lipoprotein and the pre-possessing of metabolites profile
Supplementary Table S3 from MYC Inhibition Potentiates CD8+ T Cells Against Multiple Myeloma and Overcomes Immunomodulatory Drug Resistance
Authors: Davis Lorraine N. , Walker Zachary J. , Reiman Lauren T. , Parzych Sarah E. , Stevens Brett M. , Jordan Craig T. , Forsberg Peter A. , Sherbenou Daniel W.
Published: July 2024

Supplemental Table S3. IRF4/MYC qPCR: Primary Patient Sample Characteristics
Supplementary Table S1 from MYC Inhibition Potentiates CD8+ T Cells Against Multiple Myeloma and Overcomes Immunomodulatory Drug Resistance
Authors: Davis Lorraine N. , Walker Zachary J. , Reiman Lauren T. , Parzych Sarah E. , Stevens Brett M. , Jordan Craig T. , Forsberg Peter A. , Sherbenou Daniel W.
Published: July 2024

Supplemental Table S1. Representativeness of Study Participants
Supplementary Table 6 from Cervicovaginal Metabolome and Tumor Characteristics for Endometrial Cancer Detection and Risk Stratification
Authors: Lorentzen Georgia M. , Łaniewski Paweł , Cui Haiyan , Mahnert Nichole D. , Mourad Jamal , Borst Matthew P. , Willmott Lyndsay , Chase Dana M. , Roe Denise J. , Herbst-Kralovetz Melissa M.
Published: July 2024

Spearman rank results for metabolite level correlation to depth of myometrial invasion and tumor characteristics.
Supplementary Table 4 from Cervicovaginal Metabolome and Tumor Characteristics for Endometrial Cancer Detection and Risk Stratification
Authors: Lorentzen Georgia M. , Łaniewski Paweł , Cui Haiyan , Mahnert Nichole D. , Mourad Jamal , Borst Matthew P. , Willmott Lyndsay , Chase Dana M. , Roe Denise J. , Herbst-Kralovetz Melissa M.
Published: July 2024

Statistical analysis of presence of abnormal uterine bleeding and post-menopausal bleeding in our participants. Values are n (%). P-values were calculated using Chi square and Fisher’s exact test for group comparisons.
Supplementary Table S6 from Clinical and Genomic Landscape of RAS Mutations in Gynecologic Cancers
Authors: Son Ji , Zhang Yingao , Lin Heather , Mirallas Oriol , Alvarez Ballesteros Pablo , Nardo Mirella , Clark Natalie , Hillman R. Tyler , Campbell Erick , Holla Vijaykumar , Johnson Amber M. , Biter Amadeo B. , Yuan Ying , Cobb Lauren P. , Gershenson David M. , Jazaeri Amir A. , Lu Karen H. , Soliman Pamela T. , Westin Shannon N. , Euscher Elizabeth D. , Lawson Barrett C. , Yang Richard K. , Meric-Bernstam Funda , Hong David S.
Published: July 2024

Clinical efficacy of RAS + MAPK pathway inhibitors in patients with RAS-mutated gynecologic cancers: (a) histologic breakdown and (b) multivariable analysis for overall survival in type 1, type 2, and low-grade serous ovarian cancers.
Supplementary Table 2 from Cervicovaginal Metabolome and Tumor Characteristics for Endometrial Cancer Detection and Risk Stratification
Authors: Lorentzen Georgia M. , Łaniewski Paweł , Cui Haiyan , Mahnert Nichole D. , Mourad Jamal , Borst Matthew P. , Willmott Lyndsay , Chase Dana M. , Roe Denise J. , Herbst-Kralovetz Melissa M.
Published: July 2024

Exclusion criteria for participant recruitment into study.
Supplementary Table S4 from Clinical and Genomic Landscape of RAS Mutations in Gynecologic Cancers
Authors: Son Ji , Zhang Yingao , Lin Heather , Mirallas Oriol , Alvarez Ballesteros Pablo , Nardo Mirella , Clark Natalie , Hillman R. Tyler , Campbell Erick , Holla Vijaykumar , Johnson Amber M. , Biter Amadeo B. , Yuan Ying , Cobb Lauren P. , Gershenson David M. , Jazaeri Amir A. , Lu Karen H. , Soliman Pamela T. , Westin Shannon N. , Euscher Elizabeth D. , Lawson Barrett C. , Yang Richard K. , Meric-Bernstam Funda , Hong David S.
Published: July 2024

Distribution of histology and grade used in multivariable analysis
Supplementary Table S1 from Toripalimab Plus Bevacizumab as First-line Treatment for Advanced Hepatocellular Carcinoma: A Prospective, Multicenter, Single-Arm, Phase II Trial
Authors: Chen Yajin , Du Chengyou , Shen Shunli , Zhang Wu , Shan Yunfeng , Lyu Ang , Wu Jianhui , Shang Changzhen , Luo Xuan , Wei Jinxing , Xiao Heng , Qiu Jianguo , Hua Yunpeng , Wang Shutong , Wang Ting , Dai Shengjie , Zhang Shuhao , Xie Bingying , Wu Yinghao , Hao Chunyi
Published: July 2024

Representativeness of study participants
Supplementary Figure S3 from Clinical and Genomic Landscape of RAS Mutations in Gynecologic Cancers
Authors: Son Ji , Zhang Yingao , Lin Heather , Mirallas Oriol , Alvarez Ballesteros Pablo , Nardo Mirella , Clark Natalie , Hillman R. Tyler , Campbell Erick , Holla Vijaykumar , Johnson Amber M. , Biter Amadeo B. , Yuan Ying , Cobb Lauren P. , Gershenson David M. , Jazaeri Amir A. , Lu Karen H. , Soliman Pamela T. , Westin Shannon N. , Euscher Elizabeth D. , Lawson Barrett C. , Yang Richard K. , Meric-Bernstam Funda , Hong David S.
Published: July 2024

Allelic distribution of gynecologic cancers with RAS mutations (n=516)
Supplementary Figure S2 from Toripalimab Plus Bevacizumab as First-line Treatment for Advanced Hepatocellular Carcinoma: A Prospective, Multicenter, Single-Arm, Phase II Trial
Authors: Chen Yajin , Du Chengyou , Shen Shunli , Zhang Wu , Shan Yunfeng , Lyu Ang , Wu Jianhui , Shang Changzhen , Luo Xuan , Wei Jinxing , Xiao Heng , Qiu Jianguo , Hua Yunpeng , Wang Shutong , Wang Ting , Dai Shengjie , Zhang Shuhao , Xie Bingying , Wu Yinghao , Hao Chunyi
Published: July 2024

Overall survival by ALBI grade
Supplementary Table S9 from Model-Informed Clinical Pharmacology Profile of a Novel Fixed-Dose Combination of Nivolumab and Relatlimab in Adult and Adolescent Patients with Solid Tumors
Authors: Zhao Yue , Hu Zheyi , Bathena Sai Praneeth , Keidel Sarah , Miller-Moslin Karen , Statkevich Paul , Bello Akintunde , Roy Amit , Suryawanshi Satyendra
Published: July 2024

Predicted Relatlimab Exposures for Adolescent Patients and Adult Patients with 1L MEL at 160 mg FDC Q4W
Supplementary Table S10 from Model-Informed Clinical Pharmacology Profile of a Novel Fixed-Dose Combination of Nivolumab and Relatlimab in Adult and Adolescent Patients with Solid Tumors
Authors: Zhao Yue , Hu Zheyi , Bathena Sai Praneeth , Keidel Sarah , Miller-Moslin Karen , Statkevich Paul , Bello Akintunde , Roy Amit , Suryawanshi Satyendra
Published: July 2024

Predicted Nivolumab Exposures for Adolescent Patients and Adult Patients with 1L MEL at 480 mg FDC Q4W
Supplementary Figure S1 from Model-Informed Clinical Pharmacology Profile of a Novel Fixed-Dose Combination of Nivolumab and Relatlimab in Adult and Adolescent Patients with Solid Tumors
Authors: Zhao Yue , Hu Zheyi , Bathena Sai Praneeth , Keidel Sarah , Miller-Moslin Karen , Statkevich Paul , Bello Akintunde , Roy Amit , Suryawanshi Satyendra
Published: July 2024

Model Predicted Change in Relatlimab Clearance versus Time by Patient Population
Supplementary Table S1 from Antibody–Drug Conjugate Sacituzumab Govitecan Enables a Sequential TOP1/PARP Inhibitor Therapy Strategy in Patients with Breast Cancer
Authors: Bardia Aditya , Sun Sheng , Thimmiah Nayana , Coates James T. , Wu Bogang , Abelman Rachel O. , Spring Laura , Moy Beverly , Ryan Phoebe , Melkonyan Mark N. , Partridge Ann , Juric Dejan , Peppercorn Jeffrey , Parsons Heather , Wander Seth A. , Attaya Victoria , Lormil Brenda , Shellock Maria , Nagayama Aiko , Bossuyt Veerle , Isakoff Steven J. , Tolaney Sara M. , Ellisen Leif W.
Published: July 2024

Table S1: Baseline Characteristics of the study population
Supplementary Figure S3 from Antibody–Drug Conjugate Sacituzumab Govitecan Enables a Sequential TOP1/PARP Inhibitor Therapy Strategy in Patients with Breast Cancer
Authors: Bardia Aditya , Sun Sheng , Thimmiah Nayana , Coates James T. , Wu Bogang , Abelman Rachel O. , Spring Laura , Moy Beverly , Ryan Phoebe , Melkonyan Mark N. , Partridge Ann , Juric Dejan , Peppercorn Jeffrey , Parsons Heather , Wander Seth A. , Attaya Victoria , Lormil Brenda , Shellock Maria , Nagayama Aiko , Bossuyt Veerle , Isakoff Steven J. , Tolaney Sara M. , Ellisen Leif W.
Published: July 2024

Supplementary Figure S3: COSORT diagram
Figure S2 from Tumor-Immune Signatures of Treatment Resistance to Brentuximab Vedotin with Ipilimumab and/or Nivolumab in Hodgkin Lymphoma
Authors: Gonzalez-Kozlova Edgar , Huang Hsin-Hui , Jagede Opeyemi A. , Tuballes Kevin , Del Valle Diane M. , Kelly Geoffrey , Patel Manishkumar , Xie Hui , Harris Jocelyn , Argueta Kimberly , Nie Kai , Barcessat Vanessa , Moravec Radim , Altreuter Jennifer , Duose Dzifa Y. , Kahl Brad S. , Ansell Stephen M. , Yu Joyce , Cerami Ethan , Lindsay James R. , Wistuba Ignacio I. , Kim-Schulze Seunghee , Diefenbach Catherine S. , Gnjatic Sacha
Published: July 2024

Supplemental Figure 2. Cellular marker dynamics in Hodgkin lymphoma during checkpoint blockade treatment. A. Heatmap showing markers and cell types identified through CyTOF (cytometry using time of flight) that significantly change over time. The color indicates the standardized Log2FC in protein expression (Z-Score), and the size of the circles indicate the percent of cells expressing the marker. A dendrogram of the markers sorted hierarchically is shown on the right side. B. Line plots highlight the temporal changes for each of the markers shown in A. The color separates the values per treatment. C. Heatmap showing markers and cell types significantly associated with R (Responder) and NR (Not responder). D. Regression lines for examples of markers and cell types shown in C, separating response (R) and non-response (NR).
Tumor Vessel Normalization via PFKFB3 Inhibition Alleviates Hypoxia and Increases Tumor Necrosis in Rectal Cancer upon Radiotherapy
Authors: Edelmann Marcus , Fan Shuang , De Oliveira Tiago , Goldhardt Tina , Sartorius Dorothée , Midelashvili Teona , Conrads Karly , Paul Niels B. , Beißbarth Tim , Fleischer Johannes R. , Blume Moritz L. , Bohnenberger Hanibal , Josipovic Natasa , Papantonis Argyris , Linnebacher Michael , Dröge Leif H. , Ghadimi Michael , Rieken Stefan , Conradi Lena-Christin
Published: July 2024

Treatment of patients with locally advanced rectal cancer (RC) is based on neoadjuvant chemoradiotherapy followed by surgery. In order to reduce the development of therapy resistance, it is necessary to further improve previous treatment approaches. Recent in vivo experimental studies suggested that the reduction of tumor hypoxia by tumor vessel normalization (TVN), through the inhibition of the glycolytic activator PFKFB3, could significantly improve tumor response to therapy. We have evaluated in vitro and in vivo the effects of the PFKFB3 inhibitor 2E-3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) on cell survival, clonogenicity, migration, invasion, and metabolism using colorectal cancer cells, patient-derived tumor organoid (PDO), and xenograft (PDX). 3PO treatment of colorectal cancer cells increased radiation-induced cell death and reduced cancer cell invasion. Moreover, gene set enrichment analysis shows that 3PO is able to alter the metabolic status of PDOs toward oxidative phosphorylation. Additionally, in vivo neoadjuvant treatment with 3PO induced TVN, alleviated tumor hypoxia, and increased tumor necrosis. Our results support PFKFB3 inhibition as a possible future neoadjuvant addition for patients with RC.

Significance:

Novel therapies to better treat colorectal cancer are necessary to improve patient outcomes. Therefore, in this study, we evaluated the combination of a metabolic inhibitor (3PO) and standard radiotherapy in different experimental settings. We have observed that the addition of 3PO increased radiation effects, ultimately improving tumor cell response to therapy.