bluuebunny/crossref_metadata_2025 huggingface dataset:
Relevance of stem and crown defects to estimate tree vigour in northern hardwood forests
Authors: Moreau Guillaume , Achim Alexis , Pothier David
Published: January 2020

The visual assessment of tree vigour before partial cutting is a key element of the long-term sustainability of managed hardwood forests. Several classification systems have been developed and applied to perform this task during the tree marking process. They segregate trees in different vigour classes based on the presence and severity of stem and crown defects. Yet, the relevance of using these defects to assess tree vigour has rarely been empirically validated. In this study, we analysed the relationships between quantitative vigour indicators and a full range of individual defects using 336 sugar maple and 84 yellow birch trees. Among the tested defects, the tree crown density showed the best ability to identify slow growing, non-vigorous sugar maple trees, regardless of their size. However, none of the stem-related defects, such as bark aspect, the presence of cambial necrosis or conks and stromata were strongly related to our quantitative vigour indicators. For yellow birch, none of the stem defects and crown conditions were found to be related to our vigour indicators. We conclude that, pending longitudinal studies that will provide a full empirical validation of classification systems, crown density should be used to assess recent growth and vigour of sugar maple trees and guide tree marking.
Susceptibility and remanent magnetization inversion of magnetic data with a priori information of the Köenigsberger ratio
Authors: Liu Shuang , Hu Xiangyun , Zuo Boxin , Zhang Henglei , Geng Meixia , Ou Yang , Yang Tao , Vatankhah Saeed
Published: January 2020

Magnetic susceptibility and natural remanent magnetization of rocks are useful parameters to study geological structures and geodynamic processes. Traditional widely used algorithms for the inversion of magnetic data can recover the distribution of the apparent susceptibility or total magnetization intensity, but do not provide information on the remanent magnetization. In this paper, we propose a framework to directly invert for the magnetic susceptibility and the natural remanent magnetization vector using surface or airborne magnetic data, assuming that the Köenigsberger ratio of the rock is known or approximately deducible. The susceptibility and remanence are computed using two different approaches: (1) the susceptibility, intensity, and direction of the remanent magnetization are continuously recovered for each discretized cell and (2) the remanence direction is assumed to be uniform in each subzone and is iteratively computed as discrete values. Both processes are implemented using the preconditioned conjugate gradient algorithm. The method is tested on three synthetic models and one field data set from the Zaohuohexi iron-ore deposit, Qinghai Province, northwest China. The results of the continuous inversion show the trend of the remanent magnetization directions, while the discrete inversion yields more specific values. This inversion framework can determine the source bodies’ geometry and position, and also provide superposed and comprehensive information on the natural remanent magnetization, which may be useful to investigate geological bodies bearing stable primary remanent magnetization.
Human papillomavirus infection associated with increased risk of new-onset psoriasis: a nationwide population-based cohort study
Authors: Chen Ming-Li , Kao Wei-Ming , Huang Jing-Yang , Hung Yao-Min , Wei James Cheng-Chung
Published: January 2020

Background

This study investigated whether patients with a history of human papillomavirus (HPV) infection are at increased risk of developing psoriasis.

Methods

We enrolled 66 274 patients with HPV infection between 1997 and 2013 from the Taiwan National Health Insurance Research Database, and compared them with control individuals who had never been diagnosed with HPV infection (at a 1:4 ratio matched by age, sex and index year) in relation to the risk of developing psoriasis. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), with the control group as reference.

Results

The adjusted hazard ratio (aHR) was 1.177 (95% CI, 1.010–1.373) after adjusting for demographic characteristics, comorbidities, dermatology-related outpatient visits and medications. The HPV group had an increased risk of psoriasis compared with the control group in all of the different age groups. The P-value for interaction between age and exposure of HPV is 0.009 in our sub-group analysis.

Conclusions

A higher risk of psoriasis was found after HPV infection, and age acted as an effect modifier between the HPV infection and risk of psoriasis.
Enhanced performance figures of solar cookers through latent heat storage and low-cost booster reflectors
Authors: Cuce Pinar Mert , Kolayli Sevgi , Cuce Erdem
Published: January 2020

Solar box cookers draw attention of many researchers across the globe as a promising renewable energy application for cooking purposes. Compared to other types available in literature, solar box cookers are more in the centre of interest owing to their simple and low-cost design, emerging thermodynamic performance figures, high durability and reliable cooking processes without any risk of burning food. On the other hand, cooking power and overall thermal performance of solar box cookers are still somewhat challenging to compete with the conventional cooking systems for the climatic conditions with low solar radiation potential like the Black Sea Region of Turkey. Within the scope of this research, a novel solar box cooker is devised, fabricated and tested to overcome the said shortcomings of traditional solar box cookers through natural and recycled materials. Double-glazed structure having 16-mm-thick air between two 6-mm-thick thermally resistive clear glasses is considered for aperture glazing with an area of 0.16 m2. The oven area has a depth of 350 mm, and it is entirely painted matte black for maximum solar absorption. The oven body made of stainless steel sheets is encountered by a latent heat storage medium filled by natural beeswax product, waste of propolis. Propolis is a resinous mixture that is used for protection of beehives, from either climatic changes or diseases. Polyphenols rich in balsamic part of the structure is extracted by alcohol than used for many apitherapic purposes. The remaining pulp or waste is not considered. In this study, it is used as green chemistry agents. It is found that water temperature in the cooking pot is kept over 40°C till very late hours as a consequence of latent heat storage. First figure of merit is determined to be 0.08, and the thermal efficiency of the cooker varies from 7.47 to 4.54%.
Human Immunodeficiency Virus (HIV)-Negative Men Who Have Sex With Men Have Higher CD8+ T-Cell Counts and Lower CD4+/CD8+ T-Cell Ratios Compared With HIV-Negative Heterosexual Men
Authors: Verboeket Sebastiaan O , Wit Ferdinand W , Verheij Eveline , van Zoest Rosan A , Kootstra Neeltje A , van der Valk Marc , Prins Jan M , Schim van der Loeff Maarten F , Reiss Peter ,   AGEhIV Study Group
Published: January 2020

Background

We previously reported T-cell senescence to be similar in people with human immunodeficiency virus (PWH) with suppressed viremia (predominantly men who have sex with men [MSM]) and human immunodeficiency virus (HIV)-negative otherwise comparable controls but greater than in healthy blood donors. This led us to compare CD4+ and CD8+ T-cell counts and CD4+/CD8+ ratios between HIV-negative MSM and men who only have sex with women (MSW) and relate observed differences in behavioral factors and infectious exposures, including cytomegalovirus (CMV) infection.

Methods

In 368 HIV-negative MSM and 72 HIV-negative MSW, T lymphocyte phenotyping was performed 3 times biennially. Baseline CMV serology and sexually transmitted infection (STI) incidence and/or STI seroprevalence, sexual, and substance-use behavior data were collected during study visits.

Results

Men who have sex with men, compared with MSW, had higher CD8+ counts (551 vs 437 cells/mm3, P < .001), similar CD4+ counts (864 vs 880 cells/mm3, P = .5), and lower CD4+/CD8+ ratios (1.84 vs 2.47, P < .001). Differences were most pronounced for MSM with >10 recent sex partners and partly explained by higher CMV seroprevalence in MSM.

Conclusions

These findings suggest that factors other than HIV may, in both PWH and certain HIV-negative MSM, contribute to a low CD4+/CD8+ ratio. Whether this, like in PWH, contributes to comorbidity risk in HIV-negative MSM requires further study.
Identified themes of interactive visualizations overlayed onto EHR data: an example of improving birth center operating room efficiency
Authors: Stirling Andrew , Tubb Tracy , Reiff Emily S , Grotegut Chad A , Gagnon Jennifer , Li Weiyi , Bradley Gail , Poon Eric G , Goldstein Benjamin A
Published: January 2020

Objective

While electronic health record (EHR) systems store copious amounts of patient data, aggregating those data across patients can be challenging. Visual analytic tools that integrate with EHR systems allow clinicians to gain better insight and understanding into clinical care and management. We report on our experience building Tableau-based visualizations and integrating them into our EHR system.

Materials and Methods

Visual analytic tools were created as part of 12 clinician-initiated quality improvement projects. We built the visual analytic tools in Tableau and linked it within our EPIC environment. We identified 5 visual themes that spanned the various projects. To illustrate these themes, we choose 1 exemplary project which aimed to improve obstetric operating room efficiency.

Results

Across our 12 projects, we identified 5 visual themes that are integral to project success: scheduling & optimization (in 11/12 projects); provider assessment (10/12); executive assessment (8/12); patient outcomes (7/12); and control and goal charts (2/12).

Discussion

Many visualizations share common themes. Identification of these themes has allowed our internal team to be more efficient and directed in developing visualizations for future projects.

Conclusion

Organizing visual analytics into themes can allow informatics teams to more efficiently provide visual products to clinical collaborators.
Using Inductively Coupled Plasma Mass Spectrometry to Assess Essential and Performance-Enhancing Metals in the Urine of Racehorses
Authors: Karakka Kal Abdul Khader , Perwad Zubair , K Karatt Tajudheen , Nalakath Jahfar , Subhahar Michael
Published: January 2020

Recently, an increased tendency to use various metals has been observed in the sports competition fields. Many of these metals and their organic complexes reportedly have good pharmacologic, therapeutic and performance-enhancement uses; they are banned or recommended as controlled medications in competitive sports. The objective of this research was to determine the concentration of pharmacologically relevant metals in urine samples collected from racehorses at various sport events, develop a method and assess the concentrations of above metals using inductively coupled plasma mass spectrometry (ICP-MS). Seven alkali–alkaline earth metals (lithium, sodium, potassium, magnesium, calcium, strontium and barium) and six heavy metals (chromium, cobalt, copper, zinc, arsenic and selenium) were studied in detail. To compare and confirm the concentrations of these metals, the screening was carried out on the basis of region and sex of the animal. ICP-MS provides extremely high sensitivity that enables the determination of the metals at very low concentration from complex biological matrices. From the research, it is clear that irrespective of sex and region the concentration of metal is very high in some samples, might be accidental or intentional doping to improve sporting performances. This research work is of significant importance in setting threshold values for screening metals in race day samples in order to avoid potential harmful effects on athletes and the depth of malpractices, it can bring to sports.
Gender Disparities Among Burn Surgery Leadership
Authors: Konanur Anisha , Egro Francesco M , Kettering Caroline E , Smith Brandon T , Corcos Alain C , Stofman Guy M , Ziembicki Jenny A
Published: January 2020

Gender disparities have been described in the plastic surgery and general surgery literature, but no data have been reported in burn surgery. The aim of this study is to determine gender disparities among burn surgery leadership. A cross-sectional study was performed. Burn surgeons included were directors of American Burn Association (ABA)-verified burn centers, past presidents of the ABA, and International Society for Burn Injuries (ISBI), and editors of the Journal of Burn Care & Research, Burns, Burns & Trauma, Annals of Burns & Fire Disasters, and the International Journal of Burns and Trauma. Training, age, H-index, and academic level and leadership position were compared among surgeons identified. Among the 69 ABA and ISBI past presidents, 203 burn journals’ editorial board members, and 71 burn unit directors, females represented only 2.9%, 10.5%, and 17%, respectively. Among burn unit directors, females completed fellowship training more recently than males (female = 2006, male = 1999, P < .02), have lower H-indexes (female = 8.6, male = 17.3, P = .03), and are less represented as full professors (female = 8.3%, male = 42.4%, P = .026). There were no differences in age, residency, research fellowship, or number of fellowships. Gender disparities exist in burn surgery and are highlighted at the leadership level, even though female surgeons have a similar age, residency training, and other background factors. However, gender diversity in burn surgery may improve as females in junior faculty positions advance in their careers.
Relation Between Low Pulmonary Function and Skeletal Muscle Index in Burn Patients with Major Burn Injury and Smoke Inhalation: A Retrospective Study
Authors: Won Yu Hui , Cho Yoon Soo , Kim Dong Hyun , Joo So Young , Seo Cheong Hoon
Published: January 2020

This report is to evaluate the relation between pulmonary function, respiratory muscle strength, and skeletal muscle index (SMI) in patients with major burn injury and smoke inhalation. A total of 54 inhalation burn patients were analyzed. Appendicular skeletal muscle mass (ASM) is a sum of the muscle mass of both arms and legs. SMI is adjusting for body size using body mass index (ASM/BMI). Spirometry was performed to evaluate pulmonary function. Pulmonary function tests included peak cough flow (PCF), forced vital capacity (FVC), 1-s forced expiratory volume (FEV1), forced expiratory flow rate between 25 and 75% of the FVC (FEF 25–75), FEV1/FVC ratio expressed as a percentage (FEV1/FVC %), peak expiratory flow (PEF), and maximum voluntary ventilation. Expiratory and inspiratory muscle strengths were measured. The relations between pulmonary function, respiratory muscle strength, and SMI were investigated. SMI showed significant correlations with PCF (r = 0.34 and P = 0.02), FVC (r = 0.55 and P < 0.001), FEV1 (r = 0.45 and P = 0.001), and PEF (r = 0.35 and P = 0.01). In multiple regression analysis including age, TBSA, duration of mechanical ventilation, and postburn days studied, SMI was significantly related to FVC, PCF, FEV1, FEV1/FVC, and PEF (P < 0.001, P = 0.02, P = 0.001, P = 0.04, and P = 0.03). Pulmonary function tests are significantly related to SMI in patients with major burn injury and smoke inhalation. Intensive treatment on muscle wasting in patients with burn injury has been proven to be important for improving pulmonary functions.
A review of smart manufacturing reference models based on the skeleton meta-model
Authors: Han Soonhung
Published: January 2020

Standards will allow interoperability among stakeholders in the upcoming super-connected world. A smart manufacturing reference model (SMRM) is under development inside JWG21 between ISO and IEC. Based on a dimensionality analysis and the skeleton meta-model, the eight proposed SMRMs are reviewed and compared. The SMRMs are classified according to the number of lifecycle axes and the number of dimensional axes. Also, how the concept of a digital twin can be accommodated in an SMRM is investigated.
CrossFit-related hip and groin injuries: a case series
Authors: Everhart Joshua S , Poland Sarah , Vajapey Sravya P , Kirven James C , France Thomas J , Vasileff W Kelton
Published: January 2020

To provide descriptive data on injury presentation and treatment and to identify risk factors for requiring surgical treatment for athletes presenting with CrossFit-related hip and groin injuries. CrossFit-related injuries (n = 982) were identified within a single hospital system from 2010 to 2017, with 83 (8.5% of total) identified hip or groin injuries. Patient demographics, injury diagnosis, surgical procedure and rehabilitation were assessed. Independent predictors of requiring surgery were analyzed via multivariate logistic regression analysis. Patients with hip or groin injuries were more often female (hip injuries: 63%; all injuries: 50%; P < 0.001) with mean age 34.3 years (standard deviation 10.9). Median symptom duration was 4 months with 70% reporting insidious onset. Most common diagnoses were femoral-acetabular impingement syndrome (34%), hamstring strain (11%), non-specific hip/groin pain (imaging non-diagnostic) (11%), hernia (7%) and iliotibial band syndrome (6%). Most (90%) required physical therapy (median 2 months). Surgery occurred in 24% (n = 12 hip arthroscopy, n = 5 inguinal hernia repair, n = 3 total hip arthroplasty), with 100% return to sport after arthroscopy or hernia repair. The only predictor of surgery was complaint of primarily anterior hip/groin pain (82% surgical patients, 46% non-surgical) (odds ratio 5.78, 95% confidence interval 1.44–23.1; P = 0.005); age, sex, body mass index, symptom duration and symptom onset (insidious versus acute) were non-significant (P > 0.25). CrossFit athletes with hip and groin injuries often present with prolonged symptoms with insidious onset. Most patients require several months of physical therapy and approximately one quarter require surgery. Patients presenting with primarily anterior hip/groin pain are at increased risk for requiring surgery.

Level of Evidence

IV, case series.
Access to Justice for Victims of Conflict-related Sexual Violence
Authors: Martin Claudia , SáCouto Susana
Published: January 2020

Despite persistent impunity for conflict-related sexual violence, there have been a limited number of significant cases holding perpetrators accountable within national justice systems. One of these cases is the Sepur Zarco case, in which two former military members were accused of committing acts of sexual violence, sexual slavery and domestic slavery near a military outpost in Sepur Zarco during the civil war in Guatemala. In a landmark verdict issued in February 2016, a Guatemalan court convicted the two accused, marking the first time a Guatemalan court has convicted former military members for acts of sexual violence committed in the context of the country’s civil war, and the first instance of a domestic court prosecuting sexual slavery as an international crime. In acknowledging that these acts amounted to grave crimes, the Sepur Zarco verdict changed the narrative about sexual violence in Guatemala’s conflict. Up until then — as in other conflicts in the region and beyond — sexual violence had not been recognized as a separate crime, equivalent to other crimes committed during the conflict, for which perpetrators could be held accountable. This chapter will highlight some of the critical developments prior to the case, as well as the legal and political strategies employed in the case, which led to its remarkable success. It will also offer some reflections about the challenges that have emerged since the Sepur Zarco case and the potential lessons learned for pending and future litigation of similar cases in the region.
Effect of Density and Lethargy Duration in Prerelease Packaging of the Fruit Fly (Diptera: Tephritidae) Parasitoid, Diachasmimorpha longicaudata (Hymenoptera: Braconidae)
Authors: Cancino Jorge , Leal-Mubarqui Rubén , Angulo Roberto , Pérez Cesar , Tirado Lucy
Published: January 2020

Different densities prerelease packing and times of lethargy in the fruit fly parasitoids Diachasmimorpha longicaudata (Ashmead) were evaluated in order to standardize the process of chilled insect technique for this species. Adults were kept at densities of 0.048, 0.072, 0.096, 0.120, and 0.144 parasitoids/cm2 before release in a México tower, where thermal lethargy was induced at a temperature of 2 ± 2°C for 45 min. Samples of parasitoids were collected to evaluate mortality, survival, fecundity, and flight capacity. All densities showed a similar mortality, both for males (ca. >10%) and females (ca. <7). There was no effect of density on survival and flight capacity in both sexes. On the other hand, fecundity increased with density, 1.66 sons/♀/day, similar to the control. We conclude that a density of 30,000 pupae per cage (0.144 parasitoids/cm2) is adequate for the massive prerelease packaging of the parasitoid D. longicaudata. Regarding the thermal lethargy period, 180 min under 2 ± 2°C conditions, considered as time for management, does not affect the survival, fecundity, and flight capacity of adults. The results obtained are of great utility to establish prerelease packaging parameters for D. longicaudata used in the biological control of Tephritidae fruit fly populations.
Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients
Authors: van Vliet Erwin A , Iyer Anand M , Mesarosova Lucia , Çolakoglu Hilal , Anink Jasper J , van Tellingen Olaf , Maragakis Nicholas J , Shefner Jeremy , Bunt Ton , Aronica Eleonora
Published: January 2020

For amyotrophic lateral sclerosis (ALS), achieving and maintaining effective drug levels in the brain is challenging due to the activity of ATP-binding cassette (ABC) transporters which efflux drugs that affect drug exposure and response in the brain. We investigated the expression and cellular distribution of the ABC transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) using immunohistochemistry in spinal cord (SC), motor cortex, and cerebellum from a large cohort of genetically well characterized ALS patients (n = 25) and controls (n = 14). The ALS group included 17 sporadic (sALS) and 8 familial (fALS) patients. Strong P-gp expression was observed in endothelial cells in both control and ALS specimens. Immunohistochemical analysis showed higher P-gp expression in reactive astroglial cells in both gray (ventral horn) and white matter of the SC, as well as in the motor cortex of all ALS patients, as compared with controls. BCRP expression was higher in glia in the SC and in blood vessels and glia in the motor cortex of ALS patients, as compared with controls. P-gp and BCRP immunoreactivity did not differ between sALS and fALS cases. The upregulation of both ABC transporters in the brain may explain multidrug resistance in ALS patients and has implications for the use of both approved and experimental therapeutics.
Dispute Settlement Mechanism in a Mixed-Mixed Agreement: Some Loose Ends. The Economic Partnership Agreement EU–ECOWAS–WAEMU
Authors: Fernández Arribas Gloria
Published: January 2020

The EU has developed an important practice regarding partnership agreements that has reached a new stage with mixed-mixed partnership agreements, in which the EU and its Member States are party to an agreement with another international organization and its Member States. Many issues may arise from these kinds of agreements, but this article focuses on the dispute settlement mechanism included in the Economic Partnership Agreement among the EU, Economic Community of West African States (ECOWAS), West African Economic and Monetary Union (WAEMU) and their Member States. The agreement establishes different options for dispute settlement and determining and implementing these dispute settlement mechanisms may give rise to conflicts of law, the overlapping of courts’ competences, and conflicts of competences between the organizations and their Member States or among the Member States. The EU already has a practice in place for resolving these problems, but such a mechanism is lacking in the practices of the ECOWAS and WAEMU.
Stranded abroad: a travel medicine approach to psychiatric repatriation
Authors: Felkai Peter P , Marcolongo Tullia , Van Aswegen Marius
Published: January 2020

Background

The incurred mental alteration of a traveler abroad should be an alarming signal for patient, for family and for the local healthcare professionals alike. It is estimated that 11.3% of travelers experience some kind of psychiatric problem, with 2.5% suffering from severe psychosis and 1.2% requiring more than 2 months of therapy upon return from a trip abroad. Acute psychotic episode represents approximately one-fifth of travel-related psychiatric events. Yet, the travel-related mental problems have been a neglected topic till today. Now a good selection of literature is available to help further researches.

Methods

Besides describing the most relevant literature of travel-related mental disturbances, authors present two key issues of dealing with psychiatric problems of travelers abroad: to identify the origin of the mental alteration and the process of the patient with psychiatric problems.

Results

Identifying the origin and the nature of the mental symptoms of travelers is often difficult because of the language barrier, among extraordinary circumstances. A simple two-step three-branch algorithm could make the decision easier for the attending physician. Some of the brief psychotic disorder and organic origin of mental disturbance can be and often are treated in place.

Conclusions

Some mental problems probably originated from or triggered by the travel or a foreign environment itself. In these cases the full recovery will be expected if the triggering factor is eliminated. The solution is early repatriation. The repatriation for psychiatric reasons is highly different from repatriation for other medical emergencies. The authors describe a proposal of a step-by-step action of repatriation of a psychotic patient. By the help of this suggested protocol, the patient may successfully be taken home.
Green roof and ground-level invertebrate communities are similar and are driven by building height and landscape context
Authors: Dromgold Jacinda R , Threlfall Caragh G , Norton Briony A , Williams Nicholas S G
Published: January 2020

Green roofs are increasingly promoted for urban biodiversity conservation, but the value of these novel habitats is uncertain. We aimed to test two hypotheses: (i) green roofs can support comparable invertebrate family and order richness, composition and abundances to ground-level habitats and (ii) green roofs planted with native species from local habitats will support a richer invertebrate community at family and order level than other green roofs. We sampled the invertebrate community on green roofs dominated by native grassland or introduced succulent species in Melbourne, Australia, and compared these to the invertebrate community in ground-level sites close by, and sites with similar vegetation types. The only significant differences between the invertebrate communities sampled on green roofs and ground-level habitats were total abundance and fly family richness, which were higher in ground-level habitats. Second hypothesis was not supported as invertebrate communities on green roofs supporting a local vegetation community and those planted with introduced Sedum and other succulents were not detectably different at family level. The per cent cover of green space surrounding each site was consistently important in predicting the richness and abundance of the invertebrate families we focussed on, while roof height, site age and size were influential for some taxa. Our results suggest that invertebrate communities of green roofs in Melbourne are driven largely by their surrounding environment and consequently the effectiveness of green roofs as invertebrate habitat is highly dependent on location and their horizontal and vertical connection to other habitats.
Detection of Circulating Antibodies to p16 Protein-Derived Peptides in Hepatocellular Carcinoma
Authors: Xu Yangchun , Gu Litong , Wang Jiaxin , Wang Zhenqi , Zhang Ping , Zhang Xuan
Published: January 2020

Objective

This study aimed at confirming the alteration of circulating anti-p16 immunoglobulin G (IgG) levels in hepatocellular carcinoma (HCC).

Methods

An in-house-developed enzyme-linked immunosorbent assay was used for determining plasma IgG antibodies against p16-derived antigens in 122 HCC patients and 134 healthy controls.

Results

Plasma anti-p16 IgG levels were significantly higher in HCC patients than in the controls (Z = 3.51, P = 0.0004), with no difference between males and females. A trend of increasing plasma anti-p16 IgG levels was associated with increasing HCC stage, with group 3 patients having the highest anti-p16 IgG levels (Z = 3.38, P = 0.0008). Group 3 exhibited the best sensitivity (19.6%) and specificity (95%) for plasma anti-p16 IgG detection, with an area under the receiver operating characteristic curve of 0.659 (95% confidence interval, 0.564–0.754).

Conclusion

Circulating IgG antibody to p16 protein might be a useful biomarker for HCC prognosis assessment rather than for early malignancy diagnosis.
The Grism Lens-Amplified Survey from Space (GLASS) – XIII. G800L optical spectra from the parallel fields
Authors: Abramson L E , Brammer G B , Schmidt K B , Treu T , Morishita T , Wang X , Vulcani B , Henry A
Published: January 2020

We present a catalogue of 22 755 objects with slitless, optical, Hubble Space Telescope (HST) spectroscopy from the Grism Lens-Amplified Survey from Space (GLASS). The data cover ∼220 sq. arcmin to 7-orbit (∼10 ks) depth in 20 parallel pointings of the Advanced Camera for Survey’s G800L grism. The fields are located 6 arcmin away from 10 massive galaxy clusters in the HFF and CLASH footprints. 13 of the fields have ancillary HST imaging from these or other programs to facilitate a large number of applications, from studying metal distributions at z ∼ 0.5, to quasars at z ∼ 4, to the star formation histories of hundreds of galaxies in between. The spectroscopic catalogue has a median redshift of 〈z〉 = 0.60 with a median uncertainty of $\Delta z / (1+z)\lesssim 2{{\ \rm per\ cent}}$ at $F814\mathit{ W}\lesssim 23$ AB. Robust continuum detections reach a magnitude fainter. The 5 σ limiting line flux is $f_{\rm lim}\approx 5\times 10^{-17}\rm ~erg~s^{-1}~cm^{-2}$ and half of all sources have 50 per cent of pixels contaminated at ≲1 per cent. All sources have 1D and 2D spectra, line fluxes/uncertainties and identifications, redshift probability distributions, spectral models, and derived narrow-band emission-line maps from the Grism Redshift and Line Analysis tool (grizli). We provide other basic sample characterizations, show data examples, and describe sources and potential investigations of interest. All data and products will be available online along with software to facilitate their use.
Realistic modelling of wind and supernovae shocks in star clusters: addressing 22Ne/20Ne and other problems in Galactic cosmic rays
Authors: Gupta Siddhartha , Nath Biman B , Sharma Prateek , Eichler David
Published: January 2020

Cosmic ray (CR) sources leave signatures in the isotopic abundances of CRs. Current models of Galactic CRs that consider supernovae (SNe) shocks as the main sites of particle acceleration cannot satisfactorily explain the higher 22Ne/20Ne ratio in CRs compared to the interstellar medium. Although stellar winds from massive stars have been invoked, their contribution relative to SNe ejecta has been taken as a free parameter. Here, we present a theoretical calculation of the relative contributions of wind termination shocks (WTSs) and SNe shocks in superbubbles, based on the hydrodynamics of winds in clusters, the standard stellar mass function, and stellar evolution theory. We find that the contribution of WTSs towards the total CR production is at least $25{{\ \rm per\ cent}}$, which rises to $\gtrsim 50{{\ \rm per\ cent}}$ for young (≲10 Myr) clusters, and explains the observed 22Ne/20Ne ratio. We argue that since the progenitors of apparently isolated supernovae remnants (SNRs) are born in massive star clusters, both WTS and SNe shocks can be integrated into a combined scenario of CRs being accelerated in massive clusters. This scenario is consistent with the observed ratio of SNRs to γ-ray bright (Lγ ≳ 1035 erg s−1) star clusters, as predicted by star cluster mass function. Moreover, WTSs can accelerate CRs to PeV energies, and solve other long-standing problems of the standard SN paradigm of CR acceleration.
Constraining Type Iax supernova progenitor systems with stellar population age dating
Authors: Takaro Tyler , Foley Ryan J , McCully Curtis , Fong Wen-fai , Jha Saurabh W , Narayan Gautham , Rest Armin , Stritzinger Maximilian , McKinnon Kevin
Published: January 2020

Type Iax supernovae (SNe Iax) are the most common class of peculiar SNe. While they are thought to be thermonuclear white-dwarf (WD) SNe, SNe Iax are observationally similar to, but distinct from SNe Ia. Unlike SNe Ia, where roughly 30 per cent occur in early-type galaxies, only one SN Iax has been discovered in an early-type galaxy, suggesting a relatively short delay time and a distinct progenitor system. Furthermore, one SN Iax progenitor system has been detected in pre-explosion images with its properties consistent with either of two models: a short-lived (<100 Myr) progenitor system consisting of a WD primary and a He-star companion, or a singular Wolf–Rayet progenitor star. Using deep Hubble Space Telescope images of nine nearby SN Iax host galaxies, we measure the properties of stars within 200 pc of the SN position. The ages of local stars, some of which formed with the SN progenitor system, can constrain the time between star formation and SN, known as the delay time. We compare the local stellar properties to synthetic photometry of single-stellar populations, fitting to a range of possible delay times for each SN. With this sample, we uniquely constrain the delay-time distribution for SNe Iax, with a median and 1σ confidence interval delay time of $63_{- 15}^{+ 58} \times 10^{6}$ yr. The measured delay-time distribution provides an excellent constraint on the progenitor system for the class, indicating a preference for a WD progenitor system over a Wolf–Rayet progenitor star.
Prospects of joint detections of neutron star mergers and short GRBs with Gaussian structured jets
Authors: Saleem M
Published: January 2020

GW170817 was the first ever joint detection of gravitational waves (GW) from a binary neutron star (BNS) merger with the detections of short γ-ray burst (SGRB) counterparts. Analysis of the multiband afterglow observations of over more than a year revealed that the outflow from the merger end product was consistent with structured relativistic jet models with the core of the jet narrowly collimated to half-opening angles ∼5○. In this work, assuming that all the BNS mergers produce Gaussian structured jets with properties as inferred for GW170817, we explore the prospects of joint detections of BNS mergers and prompt γ-ray emission, expected during the current and upcoming upgrades of LIGO–Virgo–KAGRA detectors. We discuss three specific observational aspects: 1) the distribution of detected binary inclination angles, 2) the distance reach, and 3) the detection rates. Unlike GW-only detections, the joint detections are greatly restricted at large inclination angles, due to the structure of the jets. We find that at lower inclination angles (say below 20○), the distance reach as well as the detection rates of the joint detections are limited by GW detectability while at larger inclinations (say above 20○), they are limited by the γ-ray detectability.
Type II superstring field theory with cyclic $L_\infty$ structure
Authors: Kunimoto H , Sugimoto T
Published: January 2020

We construct a complete type II superstring field theory that includes all the NS–NS, R–NS, NS–R, and R–R sectors. As in the open and heterotic superstring cases, the R–NS, NS–R, and R–R string fields are constrained by using the picture-changing operators. In particular, we use a non-local inverse picture-changing operator for the constraint on the R–R string field, which seems to be inevitable due to the compatibility of the extra constraint with the closed string constraints. The natural symplectic form in the restricted Hilbert space gives a non-local kinetic action for the R–R sector, but it correctly provides the propagator expected from the first-quantized formulation. Extending the prescription previously obtained for the heterotic string field theory, we give a construction of general type II superstring products, which realizes a cyclic $L_\infty$ structure, and thus provides a gauge-invariant action based on the homotopy algebraic formulation. Three typical four-string amplitudes derived from the constructed string field theory are demonstrated to agree with those in the first-quantized formulation. We also give the half-Wess–Zumino–Witten action defined in the medium Hilbert space whose left-moving sector is still restricted to the small Hilbert space.
Coinfection of H1N1 Influenza and Scrub Typhus-A Review
Authors: Jhuria L , Muthu V , Gupta S , Singh M P , Biswal M , Goyal K , Pannu A K , Kumari S , Bhalla A , Mohindra R , Suri V
Published: January 2020

The H1N1 influenza infection usually coincides with the typical scrub typhus season in North India. This leads to diagnostic difficulties due to their similar and non-specific symptoms. We describe three patients with confirmed co-infection of pandemic (H1N1) influenza and scrub typhus who had presented with acute respiratory distress syndrome. A systematic review of database yielded one case of scrub typhus and H1N1 influenza co-infection reported from South Korea. Co-infection of influenza with tropical infections may not be uncommon in endemic countries and hence a high index of suspicion on the part of physicians coupled with appropriate investigations are needed. The true burden of co-infections needs to be evaluated during outbreaks of influenza in a systematic manner.
AN ARTIFICIAL NEURAL NETWORK-BASED MODEL FOR PREDICTING ANNUAL DOSE IN HEALTHCARE WORKERS OCCUPATIONALLY EXPOSED TO DIFFERENT LEVELS OF IONIZING RADIATION
Authors: Mortazavi S M J , Aminiazad Fatemeh , Parsaei Hossein , Mosleh-Shirazi Mohammad Amin
Published: January 2020

We presented an artificial intelligence-based model to predict annual effective dose (AED) value of health workers. Potential factors affecting AED and the results of annual blood tests were collected from 91 radiation workers. Filter-based feature selection strategy revealed that the eight factors plate, red cell distribution width (RDW), educational degree, nonacademic course in radiation protection (hour), working hours per month, department and the number of procedures done per year and work in radiology department or not (0,1) were the most important predictors for AED. The prediction model was developed using a multilayer perceptron neural network and these prediction parameters as inputs. The model provided favorable accuracy in predicting AED value while a regression model did not. There was a strong linear relationship between the predicted AED values and the measured doses (R-value =0.89 for training samples and 0.86 for testing samples). These results are promising and show that artificial neural networks can be used to improve/facilitate dose estimation process.
Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym
Authors: Longo Diane M , Shoda Lisl K M , Howell Brett A , Coric Vladimir , Berman Robert M , Qureshi Irfan A
Published: January 2020

For patients with amyotrophic lateral sclerosis who take oral riluzole tablets, approximately 50% experience alanine transaminase (ALT) levels above upper limit of normal (ULN), 8% above 3× ULN, and 2% above 5× ULN. BHV-0223 is a novel 40 mg rapidly sublingually disintegrating (Zydis) formulation of riluzole, bioequivalent to conventional riluzole 50 mg oral tablets, that averts the need for swallowing tablets and mitigates first-pass hepatic metabolism, thereby potentially reducing risk of liver toxicity. DILIsym is a validated multiscale computational model that supports evaluation of liver toxicity risks. DILIsym was used to compare the hepatotoxicity potential of oral riluzole tablets (50 mg BID) versus BHV-0223 (40 mg BID) by integrating clinical data and in vitro toxicity data. In a simulated population (SimPops), ALT levels > 3× ULN were predicted in 3.9% (11/285) versus 1.4% (4/285) of individuals with oral riluzole tablets and sublingual BHV-0223, respectively. This represents a relative risk reduction of 64% associated with BHV-0223 versus conventional riluzole tablets. Mechanistic investigations revealed that oxidative stress was responsible for the predicted ALT elevations. The validity of the DILIsym representation of riluzole and assumptions is supported by its ability to predict rates of ALT elevations for riluzole oral tablets comparable with that observed in clinical data. Combining a mechanistic, quantitative representation of hepatotoxicity with interindividual variability in both susceptibility and liver exposure suggests that sublingual BHV-0223 confers diminished rates of liver toxicity compared with oral tablets of riluzole, consistent with having a lower overall dose of riluzole and bypassing first-pass liver metabolism.
Burden of baseline resistance of Mycobacterium tuberculosis to fluoroquinolones and second-line injectables in central India
Authors: Desikan Prabha , Panwalkar Nikita , Chaudhuri Shreya , Khan Zeba , Punde Ram Prakash , Pauranik Ankur , Mirza Shaina Beg , Ranjan Rajeev , Anand Sridhar , Sachdeva K S
Published: January 2020

Background

Drug-resistant TB is a serious public health problem in India. Pre-existing resistance to fluoroquinolones (FQs) and second-line injectable drugs (SLIDs) in strains of Mycobacterium tuberculosis (MTB) resistant to rifampicin (RIF) and/or isoniazid (INH) contributes to treatment failures and consequent transmission of drug-resistant TB. A baseline assessment of resistance of MTB to FQs and SLIDs may help guide policies to further improve management of drug-resistant TB in India. This study aims to determine the prevalence of resistance to FQs and SLIDs among MTB strains having RIF and/or INH resistance in central India.

Method

A total of 1032 smear positive sputum samples were subjected to line probe assay (GenoType MTBDRsl version 2) to test for resistance to FQs and SLIDs, according to the integrated diagnostic algorithm of the revised national TB control programme.

Results

Of 1032 samples, 92 (8.91%) were not interpretable and hence excluded, 295 (31.38%) were resistant to FQs alone, 13 (1.38%) were resistant to SLIDs alone, 15 (1.59%) were resistant to both FQs as well as SLIDs and 617 (65.63%) were sensitive to both FQs and SLIDs. The most common mutations in gyrA and gyrB genes were observed at codons D94G and E540V, respectively. Mutations at codon A1401G in rrs genes and in the C-14 T region of eis genes were most frequently observed.

Conclusion

High levels of FQ resistance points towards indiscriminate use of this class of drugs. Regulation for judicial use of FQs is an urgent requirement.
New drug treatment options for HIV antiretroviral therapy
Authors: Kwong Jeffrey
Published: January 2020

Current treatments for patients with HIV are not only effective at controlling viral replication but are also associated with a more favorable adverse reaction profile, may often be taken once daily, and are increasingly available in combination single-tablet regimens. This article provides an overview and prescribing considerations for several primary drugs currently recommended by the US Department of Health and Human Services.
Exploring the Networking of Academic Health Science Leaders: How and Why Do They Do It?
Authors: Lieff Susan J. , Baker Lindsay , Poost-Foroosh Laya , Castellani Brian , Hafferty Frederic W. , Ng Stella L.
Published: January 2020

Purpose

Networking is essential to leadership effectiveness in the business context. Yet little is known about leadership networking within the academic health science context. If we are going to train academic leaders, we must first understand the relational, network-based activities of their work. The purpose of this study was to explore how academic health science leaders engage in networking activities in the academic health science context.

Method

A constructivist grounded theory approach guided our study. The authors interviewed 24 academic health science leaders who were enrolled in the New and Evolving Academic Leadership program at the University of Toronto and used social network mapping as an elicitation method. Interviews, which were conducted between September 2014 and June 2015, explored participants’ networks and networking activities. Constant comparative analysis was used to analyze the interviews, with attention paid to identifying key networking activities.

Results

Academic health science leaders were found to engage in 4 types of networking activities: role bound, project based, goal/vision informed, and opportunity driven. These 4 types were influenced by participants’ conception of their role and their perceived leadership work context, which in turn influenced their sense of agency.

Conclusions

The networking activities identified in this study of academic health science leaders resonate with effective networking activities found in other fields. The findings highlight that these activities can be facilitated by focusing on leaders’ perceptions about role and work context. Leadership development should thus attend to these perceptions to encourage effective networking skills.