bluuebunny/crossref_metadata_2025 huggingface dataset:
Patients’ Perspectives towards Bedside Teaching of Medical Students: an Analytical Cross Sectional Study in Tertiary Care Hospitals
Authors: Misbah Samreen , Shakeel Maryam , Mazhar Aleena , Jamshaid Hamza , Tariq Asad , Ahmad Sagheer
Published: January 2024

Objective: To determine patients’ perspectives about medical students’ involvement in bedside teachings and its effect on the quality of consultation. Study Design and setting: An analytical cross-sectional study conducted in Combined Military and Pak Emirates Military Hospital Rawalpindi from 1-September-2019, to 1-April-2020. Methodology: Data were collected by convenience sampling using self-structured questionnaire. With a response rate of 91%, sample of 294 from medicine and surgery departments were included who had or not consultations in presence of students, excluding patients with decreased mental functioning. Kruskal-wallis and Mann-Whitney-U tests were applied to compare mean scores considering statistically significant difference at <0.05. Results: Among participants (mean age 30.8 ± 8.51) almost 138(47%) patients thought benefitted interaction with students, 191(65%) expressed disagreement to discomfort during history, which decreased towards discussing sensitive information and examination in absence of senior. Among seven domains of questionnaire, positive attitude towards students and preference of local language received the highest mean score, discomfort during the examination and students’ acceptability received the lowest. A significant difference was found among participants with higher education regarding permission for students’ presence (p-value 0.009). Conclusion: Majority of participants considered students’ interaction beneficial, but shared discomfort feeling during examination. Students’ involvement was considered imperative for their training, thinking that they are serving the community. Participants with high education reflected upon permission prior to encounter and those with less education shared that all discussion in their presence must be in understandable language
Endodontic Intervention for Managing External Inflammatory Root Resorption in Mandibular First Molar
Authors: Amir Nehal , Nazakat Ayesha
Published: January 2024

External inflammatory resorption (EIR) is the pathological destruction of external radicular structures with a multifactorial etiology. Prompt diagnosis and meticulous intervention are obligatory to retain the salvageability of the tooth and to circumvent the premature loss of permanent dentition. Infected pulpal tissues and microbial toxins are the mainstay of the persistent inflammatory response in the periodontal tissues. This provokes odontoclastic activity, precipitating radicular loss. In this report, a 17-year-old male patient reported severe pain in the mandibular right first molar. After a thorough history and examination, the case was diagnosed as inflammatory root resorption. Nonsurgical endodontic therapy was performed under rubber dam isolation. After adequate chemomechanical preparation, intracanal, non-setting calcium hydroxide was utilized to arrest the resorptive process. This case enlightens the fact that mechanical debridement alone cannot achieve the prime goal of endodontic intervention. Chemical disinfection using intracanal medicaments can magnify the outcomes by eradicating the nidus of infection
Social and Family Influence on Initiation of Smokeless Tobacco Addiction
Authors: Tahir Munira , Khan Tariq Zahid , Ahmed Zeba , Junaid Tehmina , Vasandani Rajesh , Rizvi Mohammad Hussain
Published: January 2024

Objective: This study aims to assess the family and social influence on the initiation of tobacco chewing among tobacco addicts visiting Dr. K.M Pfau civil hospital, Karachi. Methodology: A cross-sectional study was conducted at Dr. K.M Pfau civil hospital Karachi. Two groups were compared, 65 tobacco chewers who were classified as group 1, 65 more people of similar age and gender who abstained from all tobacco use were classified as group 2. Data was collected using a questionnaire about tobacco chewing addiction in parents, siblings and friends from both groups. The data was analyzed using SPSS. Results: In group 1, there were 65 tobacco chewers and in group 2, there were 65 healthy controls of alike age and gender who had no addiction. In group 1, 40% individuals had tobacco chewer parents, 14% individual’s siblings were tobacco chewers and 18% had both tobacco chewer parents and siblings. In group 2, 11% individuals had parents who were tobacco chewers, 18% had tobacco chewer siblings and 71% of the individual did not have a tobacco chewing habit in the family. This shows tobacco chewing habits are more common in people with parents and siblings having these habits rather than people who have no addiction in the family. Conclusion: Compared to non-user families, subjects of tobacco-using families had a greater prevalence of tobacco use. These findings provide guidance for creating effective tobacco reduction plans that reduce tobacco use
Կլիմայի փոփոխության ազդեցությունը համաշխարհային տնտեսության վրա / NAVIGATING CLIMATE'S IMPACT ON THE
WORLD ECONOMY
Authors: MIKAYELYAN VAHE , VARDANYAN TATEVIK
Published: January 2024

Climate change, a global phenomenon of paramount concern, has profound
implications for the world economy. This scholarly paper thoroughly examines the many
effects of climate change on the worldwide economic environment, utilizing a wide range
of research and analysis.
This study examines the direct economic impacts that result from rising
temperatures and severe weather occurrences. The text thoroughly analyzes the impact of
climate policies, such as carbon pricing and renewable energy subsidies, by evaluating
their respective expenses and advantages. Furthermore, the paper examines the economic
prospects that arise when the global economy shifts towards a low-carbon model, with a
particular focus on the expansion of environmentally-friendly industries and the
promotion of innovation.
This paper aims to offer a comprehensive understanding of the complex correlation
between climate change and the global economy. This emphasizes the immediate
requirement for synchronized worldwide efforts to reduce the negative effects of climate
change, while also emphasizing the economic prospects that come with moving to a more environmentally friendly global economy. The primary objective of this study is to
enhance the overall understanding of different viewpoints. One important discovery of the
research is that policymakers, corporations, and individuals need to effectively handle the
difficulties and possibilities arising from the changing climate conditions.
RESEARCH OF THE DRUGS MARKET REIMBURSABLE UNDER INSURANCE
Authors:   Armenian State University of Economics, AGHAJANYAN SUSANNA , KARAPETYAN LUSINE , PETROSYAN ARSEN , VARDANYAN TATEVIK , MIKAELYAN TIGRAN , AYVAZYAN ANNA , HAKOBYAN GAGIK
Published: January 2024

Health is a fundamental human right that is indispensable for the realization of many other rights, in particular the right to development and to live a dignified life. Realization of the right to health is also the fundamental goal of the state's policy. Access to medicines is a critical element of the right to health. One of the primary challenges for the government of each country is the regular provision of guaranteed quality and adequate quantity of medicines to the population, as well as the definition of a reasonable price policy. The problem of poor access to medicines is most acute in low- and middle-income countries, and the full enjoyment of the right to health remains an illusion for millions today due to barriers to access to good quality, affordable and timely medicines. From a human rights perspective, access to medicines is fundamentally linked to the principles of equality and nondiscrimination, transparency, participation and accountability. Each state is responsible for developing national health legislation, policies and strengthening its national health system. To this end, key issues related to access to medicines, such as price and quality control, drug dosage and efficacy, procurement practices and procedures, supply chains, etc., should be considered.
CHALLENGES IN THE RA BUSINESS ENVIRONMENT IN CIRCUMSTANCES OF TRANSITION TO DIGITAL ECONOMY
Authors:   Armenian State University of Economics, KTOYAN ARMEN , MANUKYAN YELENA , SHIRINYAN ANUSH , MATINYAN ANNA , HARUTYUNYAN MARIAM , BARSEGHYAN ANUSH
Published: January 2024

In circumstances of the information society, information and knowledge act as the most important economic good. Economic activity is built around acquisition, storage, processing and use of information as well as acquisition and application of knowledge in order to gain a competitive advantag and to create and meet new consumer demand. Thus, a fundamental transformation in the nature and essence of economic activity is taking place with a systemic influence on the formation of a new type of economy. The digital economy can be considered as one of the stages in the formation of a new economy following the stages of post-industrial economy, information and service economy, and the Internet economy. With this approach, the new economy can be characterized as a system of economic relations based on information and communication technologies, in which the management of ongoing economic processes is carried out using digital models. In other words, the digital economy is a manifestation of the new economy or neo-economy
LAND-USE AND TRANSPORT INTEGRATED PLANNING AND MODELLING IN CLUJ-NAPOCA, ROMANIA
Authors: Cadar Rodica Dorina , Boitor Rozalia Melania , Dragomir Mihai Liviu
Published: January 2024

The paper presents an example of successful reconversion of an industrial site located in the built-in area of Cluj-Napoca, Romania. This case study shows that land-use and transport integrated planning can be effectively implemented when a transport-oriented development (TOD) is designed for the redevelopment of an industrial site. Using TOD principles identified in the Romanian law and the technical criteria identified in the scientific literature, Sanex platform is analyzed to demonstrate it is a TOD. This would be the first documented TOD designed in Romania. A model is developed for TOD Sanex to estimate the impact that the redevelopment of the industrial platform into a multifunctional area will have on the local traffic. In this regard, two scenarios are analyzed – present scenario and future scenario after completion of the redevelopment. Two variants of the future scenario are discussed in connection to the Northern Mobility Corridor (CMN), the main project in implementation in the area, which is designed as a complete street. The results demonstrate that the induced traffic wouldn’t have a considerable impact on the local traffic now or in the perspective of the redevelopment. It can be integrated by the street network, which could operate in appropriate conditions. Considering the need of revitalization of the urban and rural industrial sites at the national scale in Romania and the benefits of TOD, a methodological framework in four steps is proposed. This framework would be a helpful support in the sustainable urban reconversion process, especially to achieve the reduced impact over the built environment and urban mobility.
WAYS OF APPLICATION OF THE CIRCULAR BIOECONOMY IN THE WINE INDUSTRY
Authors: Borta Ana-Maria , Sturza Rodica
Published: January 2024

The article reviews the conventional (composting, landspreading, tartaric acid, and grapeseed oil production) and novel ways of winemaking by-products biomass conversion with the manufacturing of value-added products to solve the disposal problem and bring extra profit to producers. Winemaking waste may be used to make biopolymers - bacterial polymers that work as a plastic alternative, and can also be utilized to make biocomposites or serve as natural fillers. It showed to be a good substrate for microorganisms for the generation of biofuels from winery waste and is the most promising, economical, and ecologically friendly option. In biotechnological applications, it can be used for the production of microbial polysaccharides, alcohols, organic acids, and enzymes, as well as single-cell protein and protein-rich fungi. The available studies indicate that it is possible to create pharmaceuticals with multiple properties of preventing or treating obesity and multiple sclerosis, atherosclerosis, diabetes, allergies, and also benefit gut microbiota. The red grape marc can be used in manufacturing encapsulated natural pigments, applicable for baked products, dairy, soft drinks, and pasta making it a feasible alternative to synthetic colorants. Considering the available opportunities, it is advised the development of industrial technologies and quality standards for the available studies introduction.
Zoohygienic assessment of carbohydrate feeds - an important component of beekeeping technology
Authors: Kuznetsov A. F. , Rozhkov K. A. , Achilov V. V. , Pechenkina A. A.
Published: January 2024

Feeding hygiene in beekeeping solves the problems of the quantity and quality of feed, increasing its usefulness, as well as monitoring the quality of feed and feed base. Providing bee colonies with a sufficient amount of carbohydrate feed of proper quality is an important component of beekeeping technology, especially in the natural and climatic conditions of the middle taiga subzone, where the honey bee (Apis mellifera) is located on the edge of the natural habitat. Noncompliance with food hygiene in such conditions dramatically reduces the adaptive capabilities of the bee organism, and can be considered as the main reason for reducing the resistance of the organism of beneficial insects. In the article, the authors touched upon the problems of hygiene of carbohydrate nutrition of honey bees, showed the possibility and real implementation of the implementation of a full-fledged carbohydrate diet in the conditions of the North-West of Russia. Carbohydrate feeds and nutrition are considered by the authors as factors determining the normal functioning of all systems of the bee organism and a means of preventing feed toxicosis.
Chemical analysis of compost produced from organic plant waste in a biothermal installation
Authors: Khomenko R.
Published: January 2024

Currently, the problem of processing various types of organic waste from agricultural and food production is becoming more pressing, since they most often have to be disposed of by paying for this service. At the same time, the cost of protein components and, as a consequence, feed is constantly increasing. The development of new technologies and technical solutions is becoming relevant. One of these technologies, which makes it possible to produce feed products for fattening animals, is the biothermal processing of organic waste using special installations. Technological solutions used in ECO biocomposters made it possible to create a completely autonomous machine for processing food and organic waste of various volumes. In our article we publish the results of a chemical analysis of the resulting compost after processing plant waste - vegetables and root crops - for compliance with certain indicators of GOST 9268-2015 (concentrated feed for cattle). The studies carried out established compliance with GOST for a number of indicators: the mass fraction of crude fat, crude protein, soluble carbohydrates, phosphorus and nitrogen was normal. An increased content of moisture and crude fiber was observed, which is associated with the composition of the starting material and the features of the technology.
The effect of the height of filling the tubes with blood on the quantitative indicators of the resulting platelet plasma
Authors: Bokarev A. V. , Minina A. O. , Kholodny R. D. , Pilipets E. Ya.
Published: January 2024

The relationship between the height of filling of test tubes with blood and quantitative indicators of platelet plasma obtained by centrifugation was studied on blood samples of Wistar rats. The test tube filling height of 6.0 cm and 3.0 cm was chosen as the comparison criteria. In combination with another criterion, such as the volume of blood placed in a test tube, a total of four (4) variants of platelet plasma production were investigated and analyzed. In the first variant (No. 1), the tubes contained 4.0 ml of blood, the height of filling the tubes was 6.0 cm. In the second variant (No. 2), the tubes contained 2.0 ml of blood, the filling height of the tubes was 3.0 cm. In the third variant (No. 3), insulin syringes were used, which contained 1.0 ml of blood, their filling height was 6.0 cm. In the fourth variant (No. 4), insulin syringes were also used, which contained 0.5 ml of blood, their filling height was 3.0 cm. All test tubes/syringes were centrifuged in the same mode (3000 rpm – 1.0 min + 1000 rpm – 10.0 min) on an OPN-3 centrifuge with a bucket rotor. Further, the concentration of platelets in the separated plasma was immediately determined at different distances from the upper layer of the erythrocyte sediment. Then the plasma was completely sampled, the platelet concentration and its volume were determined. The results were processed by methods of variational statistics. Analysis of the results showed that in variants No. 1 and No. 3, the concentration of platelets in the resulting plasma was almost 30% and 10% higher than in variants No. 2 and No. 4, respectively. Considering that the total amount of plasma obtained, expressed as a percentage relative to the initial amount of blood, was approximately the same in all variants, it can be concluded that a higher level of filling of test tubes with blood before centrifugation makes it possible to obtain plasma more saturated with platelets.
Morphometric studies of the skin of adult cows
Authors: Shafiev A. P. , Kudryashov A. A. , Safronov D. I.
Published: January 2024

Relevance. The skin of cattle consists of the epidermis and dermis. The dermis, or the skin itself, in turn consists of papillary and mesh layers. However, in the literature we have not found studies on the morphometry of different topographic areas of the skin of cattle. The aim of the study is to conduct comparative morphometric studies of the skin of various topographic zones in adult cows.

Methods. For morphometric studies, histological preparations prepared according to the generally accepted method from skin samples of different topographic areas in adult cows were used. The research was carried out at the of the St. Petersburg State University of Veterinary Medicine Department of Pathological Anatomy and Forensic Veterinary Medicine and at the Department of Biology, Ecology and Histology. Morphometric studies of histological preparations were used to study the thickness of the dermis proper, as well as bundles of collagen fibers of the mesh layer of the dermis. The results of the studies were processed using the "Biostat" program.

Results. Morphological features of the skin of different topographic areas in adult cows have been established, which are manifested by differences in the thickness of the skin layers and bundles of collagen fibers of the dermis. The morphometry performed allows us to expand the data on the morphological structure of the skin of adult cows.
Changes in the protein spectrum of blood serum of cows with mycoplasmosis when used for the treatment of Tulatromycin and Thymalin
Authors: Vasiliev R. M.
Published: January 2024

Intensive technologies of animal husbandry imply the maximum use of productive qualities of animals, the realization of which is hindered by diseases of various genesis, especially those that are accompanied by a long chronic course. Genital mycoplasmosis of cattle occupies a special place among them. The aim of our research was to study the protein spectrum of blood serum in patients with genital mycoplasmosis of the blood when used for the treatment of tulatromycin and tulatromycin in combination with thymalin. To conduct the experiment, three groups of pregnant cows were formed, 8 heads each. The first group – pregnant cows with genital mycoplasmosis for the treatment of which the antibiotic traksovet 100 (tulatromycin) was used. The second group - pregnant cows with genital mycoplasmosis for the treatment of which the antibiotic traksovet 100 and the immunomodulator timalin were used. The third group (control) – clinically healthy pregnant cows. In all groups of animals , blood serum was determined: the content of total protein, albumins, globulins and immunoglobulins of classes G, M, A. Antibiotic therapy of patients with genital mycoplasmosis of cows leads to the elimination of the pathogen from the genital tract in 75% of animals, whereas with a combination of an antibiotic and an immunomodulator, mycoplasma was not detected in any animal from the group. The use of tulatromycin for the treatment of cows with genital mycoplasmosis leads only to a partial normalization of the protein spectrum of blood serum, whereas the use of a combination of tulatromycin and thymalin for the treatment provides a complete restoration of the studied parameters to the level of clinically healthy animals.
Testing of the low-temperature Smoke generator “SMOK Insect” during deacarization of poultry premises
Authors: Ljunggren V. A. , Tokarev A. N. , Engashev S. V. , Engasheva E. S.
Published: January 2024

One of the effective ways to deacarize livestock premises is the use of aerosol checkers based on various active substances. This method provides a large coverage area and does not require additional equipment which simplifies its further use unlike the irrigation method. One of these tools is a low-temperature smoke generator "SMOKE insect" developed by LLC "Agrovetzashchita". Cyflutrin – the main active ingredient contained in the composition of the product provides a pronounced contact effect against ectoparasites affecting the nervous system and contributing to further paralysis and death of the insect. The purpose of the research was to test a low-temperature smoke generator "SMOKE insect" during the deacarization of poultry farming premises. For processing, these generators were used containing 40 g of the active active ingredient – cyflutrin. The product was used in the production premises of an egg-type poultry farm. During the tests 4 rooms were involved, each with a volume of 8000 m3. The quality control of deacarization was carried out by monitoring the appearance of a red chicken tick in a poultry house. The observations lasted 9 months. When analyzing the obtained research data it can be concluded that smoke generators showed a high acaricidal effect in the treatment modes of 640 and 960 g. per room with a volume of 8000 m3. With similar efficiency it is advisable to use the "SMOK insect" agent in the processing mode of 640 g. for a room with a volume of 8000 m3 which corresponds to the treatment of 500 m3 with a single smoke generator.
Morphobiochemical status of cows’ blood during therapy of subclinical mastitis with the complex ointment "Uberosept" together with immunomodulators
Authors: Peregonchiy A. R. , Pavlenko O. B. , Zimnikov V. I.
Published: January 2024

The studies were conducted on lactating cows of Red-Motley Holstein and Simmental breeds with subclinical mastitis aged from 1 to 8 lactations. Four groups of animals of 10 animals each were selected. The first group was treated with the complex ointment “Uberosept” once a day, externally for 5 days. The second group received “Uberosept” 1 time per day, externally for 5 days, “Mixoferon” 3 ml intramuscularly 2 times a day for 7 days. The third group received “Uberosept” 1 time per day, externally for 5 days, “Submastin-KRS” 10 ml intramuscularly 1 time per day for 3 days. Blood samples were taken from all experimental groups to study morphobiochemical indicators and indicators of lipid peroxidation, antioxidant protection and endogenous intoxication. The samples were taken before treatment, immediately after the course of treatment and 7 days after treatment. The highest therapeutic effectiveness of the treatment regimen for subclinical mastitis used in the second experimental group was 90.0%. In the first experimental group, the therapeutic effectiveness was 60.0%, in the second experimental group - 80.0%. This was confirmed by morphobiochemical studies; in the group of animals that were injected with “Mixoferon” + complex ointment “Uberosept”, immunity indicators were higher than in the group of cows that were treated with “Submastin-KRS” + complex ointment “Uberosept”. At the same time, in the animals of the third experimental group, a more pronounced decrease in the processes of endogenous intoxication, lipid peroxidation and activation of antioxidant protection was observed.
RAZUMIJEVANJE FENOMENA PORODIČNOG NASILJA
Authors: Islamović Elvira , Jakupović Tehirza
Published: January 2024

Porodično nasilje, posebno nad ženama, nije nova niti nepoznata pojava, već je gotovo uobičajeni obrazac ponašanja u skoro svim društvima tokom historije, nastao zbog tradicionalne neravnopravnosti spolova i podređenosti žena. Društveni interes za proučavanje fenomena nasilja u porodici počinje tek od sredine 20. vijeka, porastom svijesti o ravnopravnosti žena u društvu. Većina društava suočava se s fenomenom nasilja u porodici koje uključuje mnoge oblike zlostavljačkog ponašanja i predstavlja obrazac prinudnog ponašanja čija posljedica je tjelesno zlostavljanje ili prijetnja tjelesnim zlostavljanjem, ponavljajuće psihičko zlostavljanje, silovanje, socijalna izolacija, lišavanje, zastrašivanje, ekonomsko ucjenjivanje i drugi oblici zlostavljanja. Nasilje u porodici predstavlja jedan od najvećih izazova bosanskohercegovačkog društva s obzirom na brojne rizične faktore, od kojih dugotrajna politička, ekonomska i socijalna kriza i napetost u društvu te rastuće siromaštvo, stvaraju stalni pritisak na strukturu i odnose unutar porodice. Namjera ovoga rada je da iz sociološke i pravne perspektive sagleda i ukaže na ovaj rasprostranjen vid kršenja prava i sloboda značajne populacije žena, te upozori na važnost prevencije i suzbijanja nasilja nad ženama. U radu se predlažu i određene mjere za zaštitu od nasilja u porodici i prevenciju nasilja.
BANKARSKA GARANCIJA U ISLAMSKOM PRAVU
Authors: Kanurić Hakija
Published: January 2024

Bankarska garancija je instrument zaštite od rizika neizvršenja ili neurednog izvršenja obaveza nastalih određenim ugovorom. U ovom radu definira se pojam bankarske garancije, ukazuje na njene subjekte i vrste, a potom se predstavlja pravna priroda bankarske garancije u islamskom pravu. Savremeni učenjaci povezali su bankarsku garanciju s klasičnim ugovorima, kao što su jamstvo, zastupništvo i hipoteka, i na toj osnovi zauzeli su stav o pravnom statusu bankarske garancije u islamskom pravu. U radu se kritički analiziraju i kompariraju njihovi argumenti i izvode zaključci.
Proinflammatory cytokines in peritoneal fluid in women with peritoneal adhesions
Authors: Shaganov Pavlo
Published: January 2024

The objective: to investigate the level of pro-inflammatory cytokines in the peritoneal fluid in women of reproductive age with peritoneal adhesions.

Materials and methods. 58 patients verified during laparoscopy were included in the study: of them, 45 patients with stages I–II of the adhesion process, and 13 – with stages III–IV of the spread of the process. The control group consisted of 30 women of reproductive age with intact reproductive function without adhesions in the pelvis, who underwent laparoscopic sterilization. The content of IL-1, I IL-2, IL-6, and tumor necrosis factor-alpha in the peritoneal fluid was analyzed.

Results. Studies of the content of pro-inflammatory cytokines IL-1 (192.5±34.8 pg/ml and268.4±48.3 pg/ml), IL-2 (145.9±21.3 pg/ml and 234.8±42.5 pg/ml), IL-6 (118.7±8.4 pg/ml and698.4±22.6 pg/ml) and TNF-α (10.2±4.8 pg/ml and 29.6±2.8 pg/ml) in peritoneal fluid showed that their levels were significantly higher (p<0.01) in women with widespread stages of the adhesion process and the lowest in CG – 18.2±4.2 pg, respectively/ml, 22.4±4.3 pg/ml and 26.4±4.7 pg/ml. The level of IL-6 – 698.4±22.6 pg/ml in the peritoneal fluid of patients with III–IV stages of the adhesion process was significantly higher (p<0.01) than the level of IL-6 – 118.7±8.4 pg/ml in the peritoneal fluid of women with stage I–II spread of adhesions and in the control group – 26.4±4.7 pg/ml.

Сonclusions. With the increase in the prevalence of the adhesion process, there is a significant reliable increase in the content of cytokines in the peritoneal fluid, while the peritoneal fluid plays a significant role in its formation.
Validated Photodiode Array Based Stability Indicating RP-HPLC Method for Simultaneous Estimation of Cinnarizine and Domperidone Maleate in Tablet Dosage Form
Authors: B. Patel Ashok , M. Gol Akshat , M. Akhiyaniya Sonal , J. Vyas Amitkumar , I. Patel Ajay , V. Dudhrejiya Ashvin
Published: January 2024

For the simultaneous measurement of Cinnarizine and Domperidone Maleate in bulk and tablet dosage form, a accurate, reliable, robust, and cost-effective RP-HPLC method is developed. Chromatographic separation was accomplished using a mobile phase of Acetonitrile: 10mM Potassium dihydrogen phosphate (pH 3.0) (70:30% v/v) in an isocratic elution mode at a flow rate of 1mL/min on a Neuclosil C18 (25cm×4.6mm, 5µm) column at a wavelength of 271nm. Acidic, basic, oxidative, thermal, and photolytic stress environments were used to degrade the drugs. Cinnarizine and Domperidone Maleate were found to have linearities of 8–48μg/mL and 7.6–45.6 μg/mL, respectively. For both medicines, a % recovery of 99–101 was discovered. This method was validated as per ICH (Q2R1) guideline.
Determination of Physical Stability Spray Sunscreen of Extract Wungu Leaf (Graptophyllum pictum (L.) Griff) with Varied Concentrations of Glycerine as A Humectant
Authors: Rahmayanti Mayu , Tri Maulidina Annisa , Buana Putra M. Bayu Firdaus
Published: January 2024

Sunscreen is a preparation intended to counteract, reduce the effects, and protect the skin from ultraviolet (UV) radiation. Wungu leaf is one of the plants that contain antioxidants that can be used as a natural sunscreen preparation. In the manufacture of sunscreen, spray wungu leaf extract required additional materials in the form of humectants. Glycerin was chosen as a humectant with varying concentrations of 5%, 10%, and 15% in the formulation of a spray sunscreen which aims to improve the quality and maintain the stability of the resulting preparation. This study aims to determine the physical stability of the spray sunscreen preparation of wungu (Graptophyllum pictum (L.) Griff) leaf extract with varying concentrations of glycerin as a humectant. Spray sunscreen of wungu leaf extract was made in three formulas with variations in the concentration of glycerin used. The formulations that have been formulated are tested for physical stability by using the cycling test method for six cycles, and testing includes organoleptic, homogeneity, pH, viscosity, and diameter of the spray pattern. The organoleptic, homogeneity and pH tests of the preparations showed no significant changes after the physical stability test was carried out for six cycles with a significance pH value of 0.079 (<0.05). The resulting value still met the pH value criteria for topical preparations. The results of the viscosity test and spraying pattern showed an increase in the viscosity value and a decrease in the diameter of the spray pattern with a significant change with a significance of 0.01(<0.05) and 0.008 (<0.05). However, this change still met the physical criteria for topical preparations. Based on the study's results, it can be concluded that the spray sunscreen preparation of wungu leaf extract (Graptophyllum pictum (L.) Griff) with variations in glycerin concentration has good physical stability.
The Ag38-rec Mycobacterium tuberculosis Antigen as a New Candidate Marker for The Diagnostic of Tuberculosis Meningitis: In Silico Approach
Authors: Munir Badrul , Nur Hidayati Dwi Yuni , A Nazwar Tommy , Mardining Raras Triyudani , Reto Prawiro Sumarno
Published: January 2024

Tuberculous meningitis (TBM) is the most severe extrapulmonary infection caused by Mycobacterium tuberculosis (Mtb). An accurate diagnosis of TBM has yet to be established. Periplasmic Phosphate Binding Lipoprotein is a seropositive marker for TBM diagnosis. In the previous study, we tested antigen Ag38 recombinant from local strain and showed potential as a serodiagnosis agent candidate. This study aimed to analyze the variability gene of PstS1 and Ag38 rec and to identify the immune-dominant epitope protein PstS1 and 38recp. The PstS1 gene sequence of Mtb from the Mycobrowser database and 38kDa rec was obtained from the previous study. Variability gene of PstS1 and Ag38 rec was identified through the alignment of both genes. To predict the signal peptide in the PstS1 protein sequence, TargetP -2.0 was used. The candidate epitope on the mature protein was predicted with Bepipred 2.0 on the IEDB server. The results of Bepipred 2.0 were then compared with the Emini Surface Accessibility tool, Karplus and Schulz Flexibility tool, and Parker Hydrophilicity tool. The epitope obtained was further analyzed for antigenicity prediction. The position of the epitope on the 3D structure of the PstS1 protein was modeled with the help of the Ellipro predictor. The alignment result of gene PstS1 with Ag38reg contains an anonymous N base, but there were no mutations. Based on Target-P 2, it was found that the PstS1 protein contains a signal peptide with a truncation site at residues 24 and 25. From the results of the epitope prediction, ten candidate epitopes were obtained. Based on the antigenicity analysis, candidate epitopes were finally obtained. Of the five epitopes, two epitopes were similar to PstS1 Mtb protein crystallization results. Two epitopes are AGFASKTPANQAISMID-GPAPD and QGTIKTWDDPQIAALNPGVNLP. Thus, two potential epitope candidates are diagnostic biomarkers, namely AGFASKTPANQAISMIDGPAPD and QGTIKTWDDPQIAALNPGVNLP. However, further research is needed to validate these epitopes using the tool diagnosis TBM.
Applicability of Stereophotogrammetry System in Pediatric Dentistry
Authors:   Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo. Bauru, Sao Paulo, Brazil., Ambrosio Eloa Cristina Passucci
Published: January 2024

Pediatric Dentistry is one of the specialties in dentistry that aims to diagnose, plan, treat, and clinically monitor the oral health of children from birth onwards. However, a detailed analysis of the craniofacial complex is not always possible using two-dimensional scans
Comparison of Mandibular Morphology in Adult Patients with Unoperated Complete Bilateral Cleft Lip and Palate and Normal Subjects
Authors:   Assistant Professor, Department of Orthodontics, School of Dentistry, Lorestan University of Medical Science, Khorramabad, Iran, Haidari Gholamreza
Published: January 2024

Patients with Bilateral Cleft Lip and Palate (BCLP) are commonly recognized with abnormalities in craniofacial features that require orthodontic treatment to treat these abnormalities. Understanding the craniofacial development and development of these patients
Impact of Urban Proximity on the Spread of Infectious Diseases: A Case Study of Onitsha, Anambra State, Nigeria
Authors:   Department of Public Administration Federal University Gusau, Nigeria., S Ezeudu Tochukwu
Published: January 2024

The study investigates the impact of urban proximity on the accelerated spread of infectious diseases in Onitsha, Anambra State, Nigeria. Employing a mixed-methods approach, the research combines qualitative interviews and structured surveys to explore disease transmission dynamics and urban factors amplifying susceptibility.
Neuromodulation in Geriatric Depression: The Role of TMS and tDCS
Authors:   University of Pisa, Via Roma 67, 56121, Pisa, Italy, Massoni Leonardo
Published: January 2024

Neurocognitive disorders and dementia are expected to increase along with the increasing numbers of the aging population. It is known that depression occurring in old age, also known as Geriatric Depression (GD), is linked with cognitive disorders in the elderly and that old individuals with anxiety and depression often receive multiple therapies
Analyzing the effect of power loss allocation to utilities optimally in power systems using constrained load flow
Authors: Immaraju L.J.B.S. Et al.
Published: January 2024

In present day power system operation and control needs modern methodologies for controlling the power flow in power lines. Usually power electronic based converters are used for diverting/controlling the power flow through power lines which is a costlier solution. The alternative solution to this problem is to impose constraints on the system variables. In this paper, shunt capacitors are connected at loadsfor maintaining the desired magnitude at loads. Also, the losses thus obtained are allocated to respective participants (generators/loads) based on their contributions using tracing based methodology. In this, the proportional sharing principal is used to identify the contribution of participants in the power losses. The effect of imposing constraints on loss allocation to participants is analyzed at OPF (OPF) condition. For solving this, a new methodology based on improved ant lion optimization algorithm is developed. Using this method, the OPF problem wasansweredagainst system limitations. The developed methodologies are tested on standard IEEE-14 bus with supportivenumerary.
Switched Z-Source Boost Converter in Hybrid Renewable Energy System for Grid-Tied Applications
Authors: Sathish C.H. Et al.
Published: January 2024

The world's focus is shifting toward Renewable Energy Sources (RES) as a result of the sharp rise in energy demand and the depletion of conventional energy sources. Distributed generation (DG) units developed on RES are easily and reliably integrated into grid due to microgrid technology. Inverters are typically used to integrate DGs into microgrid. At present, the fastestgrowing renewable sources of electricity in the world is photovoltaic (PV) and wind energy conversion system (WECS), which evolved in response to growing environmental concerns about the risks of climate change connected with power generation. Recent technological developments have made it a top priority for researchers to find ways to enhance the efficiency of hybrid systems and the power converter stage. In order to achieve transmission losses and ensure energy savings, a new 13-bus system is developed in this work for regulating the output voltage in distribution networks. Switched Z-source Boost converter along with Proportional Integral (PI) controller is employed to boost the voltage obtained from PV system. A battery converter along with a bi-directional battery is connected to the DC link, to store energy generated by Hybrid Renewable Energy System (HRES) in excess amount. The obtained DC link voltage is transferred to three-phase voltage source inverter (VSI) for the conversion of DC to AC voltage. Effective harmonic reduction is attained with the aid of LC filter coupled to Three phase grid, and the PI controller associated to the grid supports in achieving effective grid synchronization. The proposed research is validated using MATLAB Simulink by considering the 13-bus system and an efficiency of 96.8 % is obtained with 0.93% Total Harmonic Distortion (THD).
Intelligent Research on Chinese and English Listening Teaching Based on Deep Learning
Authors: Yanghong Wu Et al.
Published: January 2024

The field of education has witnessed a transformative shift in recent years, with the integration of technology playing a pivotal role in enhancing the learning experience. In this context, recommendation systems have emerged as valuable tools for guiding learners through a vast sea of educational resources. However, privacy concerns and the need for personalized recommendations have posed significant challenges. In response, this paper introduces a novel approach, the Semantic Data Fusion Recommender (SDFR), designed to enhance English teaching while preserving user privacy with the use of federated deep learning model. The SDFR federated deep learning for semantic feature extraction from educational content and combines these features with keyword-based content analysis. Furthermore, it incorporates federated deep learning to protect user data and ensure the confidentiality of individual learning journeys. This paper present experimental results that demonstrate the SDFR's ability to provide highly accurate and personalized recommendations, significantly improving the quality of English teaching. Additionally, our approach adheres to strict privacy standards, making it suitable for deployment in educational settings. The SDFR offers a promising framework for adapting recommendation systems to the evolving landscape of online education, catering to the diverse needs of learners while safeguarding their privacy.
3D Interior Design System Model Based on Computer Virtual Reality Technology
Authors: Yu Dai Yu Dai
Published: January 2024

Globally, data volume is increases exponentially with increase in the proliferation with Cloud Computing. MapReduce is emerged as the prominent solution for the unprecedented growth in the efficient manner as it process both structured and unstructured data. The dynamic landscape of Virtual Reality has seen a significant shift towards technology-driven approaches, with data analytics and personalized learning becoming increasingly important. This paper introduces an innovative framework that leverages the power of Hadoop and MapReduce to elevate 3D virtual reality experiences within diverse VR Cloud settings. This paper presents the development of an efficient Cache-Based MapReduce framework (CMF) where Cache algorithms are effectively used to process queries on large-scale cloud-based data. The Hadoop System processes data in single-node Hadoop Clusters (Pseudo-distributed) as well as heterogeneous Hadoop Clusters (fully distributed nodes) within Amazon Web Services (AWS).  The Hadoop System process the data in the single node Hadoop Cluster (Pseudo-distributed) heterogeneous Hadoop Cluster (fully distributed node) in the Amazon Web Services (AWS). The experimental analysis is evaluated for the SmallGutenberg and LargeGutenberg database. The developed model achieves the average reduction in job of 48.01% with reduction in execution time of 51.99%. The CMF of 7-node, 9-node, 15-node and 20-node reduction in execution time is measured as 49.91%, 51.38%, 54.71% and 45.29% respectively.
Intelligent Electric Grid Maintenance via an Adaptive Predictive Maintenance Optimization Algorithm
Authors: Kiran Thatikonda Kiran Thatikonda
Published: January 2024

This study presents a novel framework for the predictive maintenance of electric grid infrastructure, leveraging an Adaptive Predictive Maintenance Optimization (APMO) algorithm. Our comprehensive system architecture integrates IoT sensors and drone surveillance, harnessing grid computing for data processing and machine learning for analytics. The APMO algorithm, underpinned by reinforcement learning, dynamically refines maintenance schedules, enhancing operational efficiency. Results from simulated sensor data exhibit a negligible correlation, indicating a multi-faceted approach to predictive analytics. Specifically, the Health Index distribution showed a wide range of 0.7 to 1.0, while the electrical current maintained a stable mean at 10 A. Further, the APMO algorithm demonstrated a promising improvement in maintenance efficiency from 40% to 75% over a year. This research introduces a scalable, robust system for grid management, paving the way for smarter infrastructure maintenance.
Impact of SNS on TGO and DA by using Data Mining Path Model
Authors: Umang Raj Et al.
Published: January 2024

This study aims to discover the impact of social networking sites on applicant quality, target group orientation and diversity of applicants. The study was conducted in Jaipur, Rajasthan, India and involved 387 respondents from different companies working at different levels in the recruitment department; mainly researcher has taken major responses form the BPO industry. Data were collected through an online survey and both descriptive and inferential statistics were used for data analysis. The results indicated that social networking sites had a significant impact on applicant quality, target group orientation and diversity of applicants. The study findings provide insights into the role of social networking sites in the recruitment process and have implications for HR practitioners and organizations. However, the study's conducted in a specific region of India and mainly in the BPO industry. Future research should expand the study's scope to different regions and industries to increase its generalizability..
Design and Development of Neuroevolutionary Algorithms for Cyber Security and Optimizing AI Models through Genetic Programming
Authors: Dharmesh Dhabliya Et al.
Published: January 2024

Different methods have been created to make optimization processes more efficient and effective, which is a big step forward in the area of evolutionary optimization. This abstract talks about four well-known methods: Neuroevolution of Augmenting Topologies (NEAT), Genetic Algorithms (GAs), Genetic Programming (GP), and Advanced Neuroevolutionary Genetic Algorithm (ANGA). It focuses on important performance indicators like Fitness Metrics, Generalization, Efficiency and Speed, and Overall Performance. With scores of 90% in Fitness Metrics and 88% in Generalization, NEAT, a neuroevolutionary program, shows strong success in competitive tasks. With an 80% score, it does poorly in Efficiency and Speed, though. GAs are known for using a population-based method. They do very well in Efficiency and Speed (90%), but they do a little worse in Fitness Metrics and Generalization (89% and 85%, respectively). With a focus on updated computer programs, GP gets marks that are equal in Fitness Metrics, Generalization, and Efficiency and Speed (88%, 85%, and 85%, respectively). The new ANGA algorithm stands out as a top worker, doing exceptionally well in all tests. ANGA gets great marks of 93% in Fitness Metrics, 94% in Generalization, and 93% in Efficiency and Speed. This shows how well it can optimize everything. Overall Performance score of 97.78% shows how well it works as a whole, making ANGA a potential method for genetic optimization.
Cognitive Linguistic Corpus Classification and Terminology Database Design Based on Multimedia Technology
Authors: Weihui Cui Et al.
Published: January 2024

With the continuous development of the social economy, multimedia has been valued more and more as a computer technology with strong professional technology and high application level. The quality of multimedia professionals is predicted and analyzed for multimedia professional talent through the Internet according to a Chinese keyword extraction algorithm. It realizes the extraction of keywords through Internet intelligence information acquisition for solving the problem of Internet information explosion, aiming to solve the talent quality prediction analysis. The prediction and analysis of multimedia professional talent quality play a crucial role in talent recruitment and development in the ever-evolving multimedia industry. This paper constructed a Fuzzy Secured Hybrid Search (FSHS) for keyword extraction in the Chinese Language. The proposed FSHS model computes the features in the text for the computation of the talent quality prediction for the extraction of the keywords. Through the utilization of the fuzzy logic model, the features in the text are computed and classification is performed classification and extraction of the features. The simulation results show that the Chinese keyword extraction algorithm has a high recall rate and precision rate, and can effectively predict the quality of professional talents.