bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening and identification of key chromatin regulator biomarkers for ankylosing spondylitis and drug prediction: evidence from bioinformatics analysis
Authors: Wanga Han , Jin Hongbo , Liu Zhiyang , Tan Chengju , Wei Lin , Fu Mingfen , Huang Yizhuan
Published: November 2022

Ankylosing spondylitis(AS) is one of the most common immune arthritic diseases in the world. Considerable efforts have been made to elucidate its pathogenesis, but the molecular mechanisms of ankylosing spondylitis are still not fully understood. To identify candidate genes in AS progression, the microarray dataset GSE25101 was downloaded from the Gene Expression Omnibus (GEO) database, differentially expressed genes (DEGs) were identified and functionally enriched for analysis, and a protein-protein interaction network (PPI) was constructed and performed using STRING and cytoHubba Modular analysis was performed, and immune cell and immune function analysis, functional analysis and drug prediction were performed. The results showed that DEGs were mainly associated with histone modifications, chromatin organization, transcriptional coregulator activity, transcriptional co-activator activity, histone acetyltransferase complexes, and protein acetyltransferase complexes. Differences in expression between the CONTROL and TREAT groups in terms of immunity were analyzed to determine the effect on TNF-α secretion. Two therapeutic agents, AY 11-7082 and Myricetin were predicted by obtaining hub genes. In conclusion, the DEGs, hub genes and predicted drugs identified in this study contribute to our understanding of the molecular mechanisms underlying the onset and progression of AS and provide candidate targets for the diagnosis and treatment of AS.
Unusual surface coagulation activation patterns of crystalline and amorphous silicate-based biominerals
Authors: Liu Chunyu , Cui Xu , Du Yunbo , Wang Xue , Kim Jua , Li Shuaijie , Zhang Liyan , Zhao Xiaoli , Zhao Limin , Tian Pengfei , Zhang Hao , Su Kun , Li Xian , Pan Haobo
Published: November 2022

Activation of coagulation cascades, especially FX and prothrombin, prevents blood loss and reduces mortality from hemorrhagic shock. Inorganic salts are effective but cannot stop bleeding completely in large hemorrhagic events, and rebleeding carries a significant mortality risk. The coagulation mechanism of inorganic salts has been oversimplified in the past two decades, limiting the creation of novel hemostats. Here, on the interface the activation of the coagulation, fibrinolysis, and cell activities were monitored at the protein level. The link between the hydrophilic-hydrophobic interface, hydration layer, microenvironmental structure of the crystal and amorphous salt, protease activity, and adsorption was also uncovered. It reveals that strong water binding and fibrinogen adsorption on kaolin's surface causes rebleeding after hemostasis, resulting in a weak thrombus. The kaolin surface inhibited the FIXa and FVIIIa composite assembly, reducing its positive feedback on the extrinsic pathway. Inspiringly, amorphous bioactive glass (BG) with transient-dynamic ions microenvironment interface are designed to bypass the barrier of the crystal structure hydration shell, hence enhancing the continuous activation of the biomaterial surface on coagulation system. Under comparative exploration, the unique coagulation pattern of BG was obtained: upon contact with the hydrophilic BGs, intrinsic and extrinsic coagulation pathways continuously initiated under the dynamic ionic microenvironment, and prothrombin complexes successfully hydrolyzed to thrombin without platelet membrane involvement, speeding the production of high-strength clots. Further evidence proves that BG more than doubled the survival rate of SD rats than kaolin in the lethal femoral artery, vein, and nerve disconnection hemorrhage model. This study investigates how the surface of inorganic salts assists in coagulation cascades that may help elucidate the clinical application of kaolin-gauze and pave the way to new materials for managing hemorrhage.
Impact of feed, light and access to fibres on tail biting in non-tail-docked pigs
Authors: Wallgren Per , Johansson Magnus , Wallgren Torun , Susic Zeljko , Sigfridson Kerstin , Johansson Sven-Erik
Published: November 2022

Background
Tail biting in pigs is a global welfare issue that has resulted in docking tails in many countries. However, tail docking by itself does not reduce the incitements for tail biting. Therefore, this study aimed to reduce tail biting in a high performing non-tail-docking pig herd with increasing incidences of tail biting.
Methods
The feed to all pigs was supplemented with amino acids, trace elements, vitamins and fibres. All pigs were also offered fibres in terms of hay silage. Thereafter four fattening stables were allotted into experimental groups as follows; I illuminated with standard fluorescent tubes with an invisible flickering of 30-40% for 14 hours per day; II illuminated with non-flickering led light for 14 hours per day; III illuminated with fluorescent tubes for 2 hours per day (this corresponded to the previous standard illumination and III served as a control group); IV similar illumination as III, but with increased access to hay silage.
Tail injuries were registered at slaughter during a period of four years prior to the trial, which was compared with the incidence of tail injuries during an adaptation period of six months and during the trial that lasted for a period of one year.
Results
The incidence of tail injuries during the four years that preceded the adaption period was 9.2%, and the incidence of tail injuries differed significantly between the buildings as well as with season.
During the adaption period, the incidence of tail injuries decreased significantly in all buildings and corresponded to 5.4%. The largest decrease was obtained in IV with extra access to hay silage where the incidence decreased from 11.4 to 4.3 %.
During the trial, the mean incidence of tail injuries continued to decrease to 3.0%. There were no significant differences between the stables.
Conclusions
The incidence of tail biting in fast growing non-tail-docked pigs was successfully reduced by supplementation of the feed with amino acids, trace elements, vitamins and fibres. Additional manipulative material in terms of hay silage accelerated that process and non-flickering illumination may have an impact in preventing tail biting.
The results obtained argue for the un-necessity of tail docking pigs, provided that the needs of the pigs in terms of feed ingredients, stocking density and access to manipulative materials are fulfilled.
Does Food Neophobia Affect Mediterranean Diet Adherence and Eating Disorders in University Students?
Authors: OZKAN Nilufer , GUL Fatma Hazan
Published: November 2022

Purpose
Food neophobia can describe the fear of the unfamiliar foods. It has many causes such as environmental, cultural, and genetic factors. This situation reduces the consumption of new or unfamiliar foods as well as other foods. The aim of this study is to investigate does food neophobia affect mediterranean diet adherence and eating disorders in university students.
Methods
In this cross-sectional study, 1277 university students were included between the ages of 18–24. The data were collected an online questionnaire. The questionnaire consisted of sociodemographic characteristics, Food Neophobia Scale (FNS), Mediterranean Type Diet Quality Index (KIDMED) and, Eating Disorder Examination Questionnaire (EDE-Q).
Results
Men's FNS scores (38.5 ∓ 10.97) were significantly lower than women (40.8 ∓ 9.21). Likewise, men's EDE-Q score (3.5 ∓ 3.32) was found to be significantly lower than females (4.4 ∓ 4.05). 69.5% of the individuals did not experience food neophobia, underweight (11.0%) were more neophobic than obese (4.4%) and there was no significant difference according to BMI classification (p > 0.05). A positive correlation was found between age and KIDMED, and a negative correlation was found between BMI and EDE-Q for the food neophobia.
Coclusion
There is a positive significant correlation between the EDE-Q score and subscales and BMI, and a negative significant relationship between KIDMED. A positive correlation was found between age and KIDMED, and a negative correlation was found between BMI and EDE-Q for the food neophobia. Food neophobia may affect mediterranean diet adherence and eating disorders in university students. Further research is recommended to obtain more certain data.
Level of evidence:
Level V, cross-sectional descriptive study.
The composition and natural variation of the skin microbiota in healthy Australian cattle
Authors: Gamage Hasinika K.A.H. , Vuong Daniel , Minns Scott A. , Chen Rachel , Piggott Andrew M. , Lacey Ernest , Paulsen Ian T.
Published: November 2022

Background Skin diseases in cattle pose significant animal welfare issues and financial burdens. Microbial communities inhabiting the skin have essential roles in maintaining host health. Microbiota manipulation can be an efficient strategy for improving the productivity and sustainability of skin disease management. However, a lack of information on the skin microbiota of healthy cattle and how environmental and host factors drive its normal variation has limited using skin microbes for diagnosing or treating skin disease and pest infestation in cattle. Here, we profiled the skin microbiota of 1,734 healthy cattle from 25 different herds located in a 187,000 km2area in the northeast to east Australia using 16S rRNA gene amplicon sequencing. The impact of host and climatic conditions on the skin microbial populations was examined. Results Our results demonstrate a highly diverse microbiota on the skin of healthy cattle. While the structure and diversity of microbial communities varied between herds, several bacteria were present consistently despite the differences in environmental conditions. For example, bacterial familiesMoraxellaceae,Sphingomonadaceae,BacillaceaeandBurkholderiaceaewere observed in most cattle, however, their relative abundance varied significantly between herds. Solar exposure and rainfall were key factors contributing to the observed variations in skin microbiota between herds, while temperature and cattle breed did not show any statistically significant impact on the composition of cattle skin microbiota. Conclusions This is the first report of the composition of the commensal skin microbiota of healthy cattle, specifically herds located in the northeast to east Australia and the impact of environmental and host variables on these microbial communities. Our study provides valuable insight into normal variation in cattle skin microbiota, an essential step for developing skin microbiota-based therapies for skin disease present in cattle.
Electrochemical analysis of the fabricated cell with PVA based silver ion conducting Gel Polymer Electrolyte
Authors: Parthiban V. , Sundari G. Sunita , C.V.S Brahmananda Rao , Erothu Harikrishna
Published: November 2022

Electrochemical analysis of Silver ion conducting Gel polymer Electrolyte (Ag-GPE) was done with Linear sweep Voltammetry (LSV) and Cyclic Voltammetry (CV). The silver ion conducting GPE was prepared by solution casting technique with PVA as polymer, AgBF4 as salt and de-ionized water as solvent. The synthesized films were-characterized using XRD and-FTIR to study the structural and functional characteristics of GPE and confirmed the complexation between polymer and salt. The optical properties of the Ag-GPE sample was studied by UV-Vis spectrophotometer. The highest ionic conductivity, 1.28 × 10− 5 Scm-1 was observed for Ag-GPE sample (60:40 wt%) by AC impedance. Dielectric studies of Ag-GPE samples were done from AC impedance data. LSV used to analyze the electrochemical working voltage of the synthesized material, which is found to be 1.1V. CV studies were done for highest ion conducting GPE (60:40 wt%) by fabricating two different cells. The first cell SS/GPE/Ag showed good stability up to 25 cycles and the second cell Ag/GPE/Zn was analysed for the re-dox reaction of the cell which shows the electrochemical behaviour of battery and confirmed that, the synthesized material can be used for energy storage applications.
DCNR: A Transfer Learning Approach for Detecting and Classifying Non-FunctionalRequirements from User Reviews
Authors: Tasnia Khandaker Rifah , Mehjabin Nafisa , Aziz Md. Ashif , Kamal Abu Raihan Mostofa , Khatun Afrina , Lota Lutfun Nahar
Published: November 2022

With the increasing popularity of the web and mobile devices, mobile applications (Apps) are now used for a wide range of purposes. As mobile experiences are becoming more user-centered, system design is entirely dependent on who is using the app. For the success of the application, developers need to be aware of the users’ concerns and expectations of the application. Existing research has demonstrated that user evaluations often raise issues with an app’s usability, dependability, performance, or aesthetic appeal. These issues should be seen as Non-Functional Requirements (NFRs) in order to develop an application that meets users’ needs in all aspects. Since user reviews are often short, unstructured, and written in informal language, it might be hard to label them according to the standards of NFRs. In this context, our paper proposes a DCNR (Detection and Classification of Non-functional Requirements) approach that fine-tunes transformer language models (BERT, RoBERTa) to perform the classification tasks on our labeled UR-NFR dataset. In this approach, user reviews that contain requirements are identified automatically and further classified into seven different categories of NFRs (Usability, Look and Feel, Reliability, Portability, Performance, Maintainability, and Functional Suitability). Comparing the experimental results using existing machine learning techniques (Naive Bayes, BoW, TF-IDF), we found that our DCNR outperforms the existing approach. Among the two transformer-based language models incorporated by DCNR method, RoBERTa achieved better results than BERT in binary requirement and non-requirement classification, as well as in the multiclass classification of NFRs. In the binary classification and the multiclass classification of NFRs, the RoBERTa model has attained f1 scores of up to 88.2% and 70.7%, respectively. Overall, it can be concluded from the findings that transfer learning has a promising effect on improving the performance of our proposed approach.
RETHINKING THE DEVELOPMENT MODEL OF RURAL TERRITORIES IN MODERN CONDITIONS
Authors:   Federal Rostov Agricultural Research Centre,Rassvet, Russia, Miroshnichenko T.
Published: November 2022

Numerous socio-economic problems of villages and ongoing civilizational transformations require rethinking of a model of rural development. The subject of the study is the principles and mechanism for managing the sustainable socio-economic development of rural territories. The purpose of the study is to justify the new model of sustainable inclusive development of rural areas, which contributes to the growth of economic capabilities, the level of social security and the quality of life of the rural population throughout the country. Research methods. In the course of the study, methods of induction and deduction, economic-statistical analysis, monographic and abstract-logical methods have been used. Research results. The exogenous model of the rural territories development has not been able to ensure the growth of the quality of life of the rural population for many years. The fifth of rural residents still belongs to the poor. A distinctive feature of rural poverty is its high level among the working population, which makes an unattractive living in the village. Therefore, a transition to a new model of development of rural areas based on the principles of inclusiveness is necessary: providing all residents of the village of equal opportunities for self -realization and access to public benefits, the development of the rural economy, taking into account the specifics of the territories, the growth of employment, ensuring comparability of the level and quality of life, regardless of the place of residence, regardless citizens who contribute to the preservation of human capital in the village and territorial equality. The mechanism for managing the proposed model of rural development is based on the development, coordination and implementation of strategies and plans for the development of rural territories from municipal to the federal level with the annual monitoring of the achievement of target indicators and evaluating the effectiveness of officials
ESSENTIAL CHARACTERISTIC OF SCIENTIFIC POTENTIAL AND SCIENTIFIC CAPITAL OF INNOVATIVE INDUSTRIAL ENTERPRISE
Authors:   JSС Russian Institute of Radio Navigation and Time, Saint-Petersburg, Vlasov, N. , Palkina E. ,   State Marine Technical University Saint-Petersburg, Koch L. ,   State Marine Technical University Saint-Petersburg
Published: November 2022

In modern conditions the importance of effective and efficient implementation of the import substitution program in the country, technological breakthrough, accelerated development of key industries based on the development and implementation of innovations is increasing in order to ensure sustainable socio-economic development of the Russian Federation. The theoretical basis of innovation management consists of the concepts of scientific potential and scientific capital of the organization. The purpose of this work is to study the essence of the scientific potential and scientific capital of the organization, taking into account the specifics of the knowledge-intensive activities of an industrial enterprise. The subject of the study is the essential characteristic of the concepts under consideration, which allows to determine their distinctive properties and content structure. Methods of analysis and synthesis, abstraction, generalization and grouping have been used in the research process. The article presents the results of the study of existing approaches to determining the essence of scientific potential and scientific capital. The authors' interpretation of the concepts under consideration has been proposed, which based on the assessment of the resources and competencies of manufacturing enterprises. The main components of scientific potential and scientific capital that form an objectified structural basis for innovation management in industrial organizations and their distinctive properties have been highlighted. The process of realizing scientific potential through the cantilevered transformation of hidden competencies into open ones has been described. The importance of including marketing competencies in the structure of scientific capital and scientific potential of an industrial organization has been noted. The field of application of the results obtained: innovation management of industrial organizations. Thus, the essential characteristic of scientific potential and scientific capital presented in the work forms theoretical basis for the development of innovation management methodology and, in the applied aspect, allows to comprehensively take into account the basic components of effective and efficient management of knowledge-intensive activities of a manufacturing enterprise
Erkenntnisse und Perspektiven zum digitalen ‹Notfalldistanzunterricht›
Authors: Rau Franco
Published: November 2022

In vielfältigen pädagogischen Handlungsfeldern stellt sich aktuell die Frage, inwiefern die in der Corona-Pandemie gewonnenen Erfahrungen und Erkenntnisse zur Gestaltung von Vermittlungs- und Erziehungssituationen mit digitalen Medien langfristig genutzt werden können. Mit der Vorstellung und Diskussion von drei empirischen Studien soll dazu beigetragen werden, die Bedeutung der Erfahrungen der coronabedingten digitalen (Distanz-)Formate für eine (Medien-)Bildung in einer digital geprägten Welt einschätzen zu können. Mit den ausgewählten Studien werden jeweils spezifische Einblicke in die Erfahrungen von Lehrpersonen, Familien und Lerntherapeut:innen mit dem «Notfalldistanzunterricht» während der ersten Schulschliessungen gegeben. Wenngleich die drei eher explorativen Studien nicht den Anspruch erheben, verallgemeinerbare Aussagen zu treffen, bieten sie in vergleichender Betrachtung interessante empirische Indikatoren zur Rekonstruktion eines Gesamtbildes zu den Chancen und Herausforderungen der digitalen Distanzlernangebote im Rahmen des ersten Lockdowns. Die in allen drei Studien beschriebene Praxis der Lehrorganisation des digitalen Verschickens von Arbeitsblättern erscheint aus mediendidaktischer Perspektive ernüchternd. Positiv betrachtet lässt sich dies als erster Schritt der Akteure verstehen, digitale Möglichkeiten zu erkunden und Erfahrungen zu sammeln, um langfristig medienpädagogische Kompetenzen zu entwickeln. Die in der Corona-Pandemie gewonnenen Erfahrungen stellen so bestenfalls einen zentralen Anlass und den Beginn langfristiger individueller und institutioneller Entwicklungsprozesse dar, welche Begleitung und Unterstützung benötigen.
Hereditary ovarian cancer
Authors: Kotiv Kh. B. , Gorodnova T. V. , Sokolenko A. P. , Berlev I. V. , Imyanitov E. N.
Published: November 2022

Background. Hereditary genetic mutations are a significant risk factor for malignant transformation of cells and cancer development. Hereditary genetic mutations account for 15 to 25 % of all ovarian carcinomas. Purpose of the study: to summarize data on hereditary ovarian malignancies, namely: genetic defects, features of the clinical course, treatment options, and disease prevention. Material and methods. A systemic search was undertaken using PubMed, Medline, Cochrane Library databases for publications from 1999 to 2021. Results. The review describes the main genetic defects and hereditary cancer syndromes predisposing to the development of hereditary malignant ovarian tumors. The features of the clinical course and response to drug therapy have been presented. This article summarizes clinical guidelines of the professional communities (National Comprehensive Cancer Network (NCCN), American Society Of Clinical Oncology (ASCO), The U.S. Preventive Services Task Force, and European Society For Medical Oncology (ESMO). These guidelines contain early detection strategies and approaches to prevent the development of cancers in mutation carriers. Conclusion. Detection of hereditary cancer syndromes is important for patients and their families. Recognizing hereditary predisposition to cancer is important to allow timely surveillance and preventative interventions for both patients and family members.
Early rehabilitation of cancer patients after endoprosthetic reconstruction following resection of the lower extremity long bones
Authors: Bukharov A. V. , Filonenko E. V. , Erin D. A. , Derzhavin V. A. , Yadrina A. V. , Shatalov A. M. , Elkhov D. O. , Aliev M. D.
Published: November 2022

Aim of the study: to conduct a systematic analysis of the data available in the modern literature, prognostic factors, and modern methods of rehabilitation of cancer patients after endoprosthetic reconstruction following resection of the lower extremity long bones. Material and methods. We assessed reports of clinical trials published over the past 10 years, which evaluated prognostic factors, rehabilitation programs for cancer patients who underwent endoprosthetic reconstruction following resection of the lower extremity long bones, depending on the location and size of the implant and the age of the patient. The review also evaluated various prognostic factors that affected functional recovery following resection of the lower extremity long bones. Results. Findings that helped in choosing the best option for surgical treatment, thus providing the best quality of life in the postoperative period, were published. Conclusion. Further studies are needed to optimize rehabilitation techniques and develop new algorithms for the treatment of cancer patients who underwent endoprosthetic reconstruction following resection of the lower extremity long bones.
Reactivaion of immune-related colitis during targeted therapy in a patient with metastatic cutaneous melanoma
Authors: Degtiareva E. A. , Protsenko S. A. , Imyanitov E. N. , Teletaeva G. M. , Latipova D. Kh. , Semenova A. I. , Novik A. V.
Published: November 2022

Background. The development of unique immune-related adverse events (irAEs) is a known hallmark of immunotherapy. Generally, such complications occur during the first 3–6 months of immunotherapy, however, the experience with immune checkpoint inhibitors (ICIs) shows that irAEs can also occur after completion of ICI therapy, as well as during other anticancer treatment regimens. Description of the clinical case. We present a clinical case of a patient with metastatic cutaneous melanoma, who had recurrent events of grade 2 immune-mediated diarrhea during the 2ndline of therapy. After completion of the course of immunosuppressive therapy with systemic glucocorticoids, irAE resumed, and mesalazine and budesonide (local steroid) with subsequent dose reduction were prescribed. Maintenance anti-inflammatory therapy and re-induction of targeted therapy with BRAF- and MEK-inhibitors due to the progression of the disease resulted in the reactivation of immune-mediated colitis. The complication was successfully managed by increasing dose of local steroid to full dose. Anticancer therapy was continued at the same regime without recurrent episodes of irAEs. Conclusion. When changing the anticancer treatment regimen, the recurrence of irAEs dictates careful monitoring of toxicity and the importance of timely selection of the optimal treatment algorithm to improve the quality and longevity of cancer patients.
Predictive and prognostic significance of loss of heterozygosity in ABC transporter genes in breast cancer
Authors: Tsyganov M. M. , Ibragimova M. K. , Garbukov E. Yu. , Bragina O. D. , Zdereva E. A. , Usynin E. A. , Litviakov N. V.
Published: November 2022

ABC-transporter family genes have been well studied and their involvement in the development of drug resistance has been assessed. The presence of aberrant conditions in these genes can affect the treatment and prognosis of the disease. Loss of heterozygosity (LOH) is one of these conditions; it is a common event in cancer development. therefore, The aim of this study was to investigate the relationship between LOH in ABC transporter genes in breast cancer and response to chemotherapy and disease prognosis. Material and methods. a total of 130 breast cancer patients were included in the study. microarray analysis was performed on Affymetrix Cytoscantm HD Array high-density DNA chips to assess LOH status. Chromosome Analysis Suite 4.1 software (Affymetrix, USA) was used to process microarray results. Results. Forty-nine ABC transporter genes were evaluated for LOH. the frequency of LOH ranged from 6.9 % to 90 %. an association analysis identified two genes: ABCG5 and ABCG8, in which the presence of LOH was associated with a lack of objective response to neoadjuvant chemotherapy. the presence of LOH in the ABCA5, ABCA6, ABCA8, ABCA9, ABCA10 and ABCC3 genes was associated with high rates of metastasis-free survival (log-rank test, p<0.04). Conclusion. The presence of loss of heterozygosity in the ABC transporter genes was found to have no significant effect on the response to chemotherapy. However, a high prognostic potential of ABCA family genes was found.
EPCAM+CD45+ cells in ascitic fluid of patients with ovarian cancer: a relationship with tumor marker levels and tumor grade
Authors: Kozik A. V. , Kaigorodova E. V. , Grishchenko M. Yu. , Vtorushin S. V. , Chernyshova A. L.
Published: November 2022

Purpose of the study: to assess the relationship between atypical/hybrid forms of EpCAM+CD45+ cells in ascitic fluid of ovarian cancer patients and the levels of cancer markers, such as CA125 and HE4, and the tumor grade. Material and methods. The study included 48 patients with newly  diagnosed ovarian cancer (42 patients with stage Ic–IV ovarian cancer and 6 patients with borderline ovarian tumors (Bots). The age of the patients ranged from 36 to 76 years. the study material included ascitic fluid and blood samples. the presence of atypical/hybrid forms of EpCAM+CD45+ cells in ascitic fluid was identified by laser multicolor flow cytometry. The levels of CA125 and HE4 markers were measured by ELISA. Results. The number of EpCAM+CD45+ cells in ascitic fluid of patients with serous ovarian carcinoma was 1.02 (0.30; 2.68) cells/µl (0.55 (0.03; 4.51) cells/µl in patients with low-grade serous carcinoma (LGSC) and 1.36 (0.41; 2.68) cells/µl in patients with high-grade serous carcinoma (HGSC). The number of EpCAM+CD45+ cells in ascitic fluid of serous ovarian carcinoma was shown to have a strong  correlation with СА125 and HE4 levels in blood serum (R=0.60; р<0.01 and R=0.34; р=0.05, respectively). In the LGSC group, there was a strong direct  correlation between the number of EpCAM+CD45+ cells in ascitic fluid and the levels of CA125 and HE4 markers in blood serum (R=0.93; p<0.01 and R=0.68; p=0.03, respectively). No differences in the levels of EpCAM+CD45+ cells in ascitic fluid and CA125/ HE4 markers in blood serum between patients with HGSC and LGSC were found. the levels of atypical/hybrid forms of cells in ascitic fluid and CA125/ HE4 markers in blood serum were  significantly lower in patients with Bots than in patients with serous ovarian carcinoma (p=0.02 for EpCAM+CD45+ cells and p<0.01 for СА125/ HE4 levels). Conclusion. The relationship between the number of EpCAM+CD45+ cells in ascitic fluid and the levels of CA125 and HE4 markers in blood serum of patients with serous ovarian carcinoma was found. However, no differences in the levels of EpCAM+CD45+ cells in ascitic fluid and CA125/ HE4 markersin blood serum between patients with HGSC and LGSC were observed.
Changes in the content of hormones of hypothalamic-pituitary-thyroid axis in growth of single and multiple primary tumors in the presence of comorbidity
Authors: Kit O. I. , Frantsiyants E. M. , Kaplieva I. V. , Bandovkina V. A. , Shikhlyarova A. I. , Goroshinskaya I. A. , Cheryarina N. D. , Neskubina I. V. , Pogorelova Yu. A. , Surikova E. I. , Trepitaki L. K. , Kotieva I. M. , Shumarin K. A.
Published: November 2022

Introduction. Thyroid dysfunction is known to be associated with higher risks of cancer development. The purpose of this study was to analyze levels of thyroid axis hormones in the hypothalamus, pituitary gland, thyroid, and blood serum of male and female Balb/c nude mice with B16/F10 melanoma and/or lewis lung carcinoma. Material and methods. Male and female Balb/c nude mice were divided into groups: 1 – intact mice (n=7), 2 – mice with b16/f10 melanoma (n=7), 3 – mice with lewis lung carcinoma (LLC) (n=7), 4 – mice with melanoma and LLC (n=7). Levels of thyroid-stimulating hormone (TSH), triiodothyronine (fT3), and thyroxine (fT4) were measured by ria in homogenates of the hypothalamus, pituitary gland, thyroid and blood serum of all animals, and TH-releasing was measured by ELISA. Statistical processing of results was performed using the Statistica 10.0 program. Results. TH-releasing was reduced in the hypothalamus of all tumor-bearing mice, compared to initial values. TSH levels in the pituitary gland and thyroid were changed only in males with the combination of tumors (increased by 2.8 and 1.5 times, respectively). Levels of free forms of hormones in the thyroid in animals of both genders sharply increased, together with the elevation of TSH in the blood serum and, as a result, the decrease of fТ3 and fТ4 levels. Conclusion. Female and male Balb/c nude mice of the studied groups demonstrated hypothalamic dysfunction manifested by the absence of regulation in the hypothalamus-pituitary-thyroid relationship, and by the hypothyroid status of animals.
Islamic Innovation in Malaysian Public Service
Authors:   Department of Syariah and Management, Academy of Islamic Studies, Universiti Malaya, Kuala Lumpur, Malaysia, Abdul Ghani Azmi Ilhaamie , Hashim Junaidah ,   Department of Business Administration, Kulliyyah of Economics and Management Science, International Islamic University of Malaysia, Selangor, Malaysia
Published: November 2022

Presently, there are few articles that discuss on Islamic innovation. Henceforth, this article will try to elaborate on this matter about the concepts, principles, purpose, factors of innovation in Islam, famous Islamic scholars for innovation and modern Muslim innovators. In addition, this article will also elaborate the concepts of Islamic innovation which are tajdid, islah and ijtihad in Malaysian public service context by using library research method i.e., through examining online reports, document review from previous research, and Quran and Hadith verses. This understanding is pertinent as Malaysia is an Islamic country whereby Islam is the official religion. The public sector should be spearheading innovation in the country to elevate the country to greater heights.
Successful balance of occlusal plane using functional orthopedics appliance
Authors: Bovi Corsi Murilo
Published: November 2022

In this article, the treatment of two clinical cases is presented, in which the two patients showed distocclusion, severe overbite, required correction of the occlusal plane and movements of the mandible. Both were treated with functional orthopedic appliances In the first case. the patient was 4 years and 5 months old, and in second, 10 years 10 months old. Both had a significant pathological occlusal plane with a large difference in the height between the right and left sides. The lateral movements of the mandible showed completely different Functional Masticatory Angle Planes. The protrusion and opening movements of the mandible also showed deviation. The Functional Orthopedic appliance would advance the position of the mandible forward and would produce better responses if it were able to touch the incisors in the specific area. The forward mandibular position would activate the Ihh (Indian Hedgehog) and produce replication of the mesenchymal cells in the condyle and glenoid fossa. Moreover, it could produce an increase of mandibular length, and regulate the factors of mandibular condylar growth. The space produced between the occlusion as a result of the change to the forward mandible position must stimulate tooth eruption to correct the curve of the occlusal plane. Both cases showed balance of the occlusal plane and same functional masticatory angle Planes. Furthermore, the protrusion and opening movement of the mandible were corrected and no longer showed deviations. Note in both cases that the stability of the mandibular advancement occurred due to maintenance of twice as long to achieve incisor contact.
Functional orthopedic device type Sn20 – a therapeutic resource in the control of chronic temporomandibular dysfunction – case report
Authors: Machado C. A. O. , Simamoto P.-C.
Published: November 2022

The literature indicates that patients with a history of Temporomandibular Disorder (TMD), who experience sudden occlusal changes, may worsen their parafunctional habits and develop TMD again. In this sense, the aim of this study is to present a clinical case of recurrent chronic TMD after oral rehabilitation (increase of vertical dimension in all teeth) using Simões Network 20 (SN20) functional orthopedic appliance as one of the resources therapies. The patient was female, 62 years old, and complained of disabling pain, anxiety symptoms, hypervigilant and history of TMD. The patient reported failure of other treatment modalities, including use of the smooth stabilizer device. The diagnosis was chronic TMD – primary osteoarthritis of the temporomandibular joint and related myofascial pain and orofacial migraine. Treatment included physical measurements, instructions, peripheral and central medication, AOF type SN20 (night use). After three months of therapy, the patient showed significant improvement with complete pain reduction. The use of the AOF SN20 together with conservative measures represents a valuable therapeutic modality for patients with chronic TMD.
Strategizing the Exit from Subsidized Economy in the Kabardino-Balkarian Republic
Authors: Midov Aslan
Published: November 2022

Many Russian regions depend on gratuitous transfers from the federal center. These regions lag behind the average Russian level of economic development and standard of living, which creates uneven prerequisites for economic growth. In addition, such regions attract no investments, and the effectiveness of the use of federal money is often impossible to assess. These conditions lead to inequal economic development, living standards, and welfare in different regions, which creates social tension and hinders the economic growth of the whole country. The research relied on the theory of strategy and methodology of strategizing developed by V.L. Kvint, Foreign Member of the Russian Academy of Sciences and Honored Worker of the Higher School of the Russian Federation, whose projects have been successfully implemented in a number of regional and sectoral strategies. According to the general methodology of strategizing, new opportunities are determined by analyzing global, sectoral, and regional trends. The present research featured the subsidized region of the Kabardino-Balkarian Republic. The proposed term of subsidized economic condition made it possible to take into account the peculiarities of such regions during strategizing. The author developed some tools for assessing the effectiveness of the Kabardino-Balkarian Republic’s exit strategy from subsidized economy. The main strategic priority was to improve the quality of life in the region, as well as to increase the level of its financial independence. Conclusion. The analysis made it possible to identify and substantiate the theoretical features of strategizing the exit from subsidized economy, as well as to develop some tools for assessing the effectiveness of this strategy for the Kabardino-Balkarian Republic.
Development Strategizing of Urban Systems Based on Multifractal Dynamics
Authors: Nikonorov Sergey , Krivichev Alexander , Nasonov Andrey , Tsvetkov Ilya
Published: November 2022

This article introduces a new analysis algorithm that can be applied to territorial organization of urban systems. After directed zoning, the zones are divided into those of balance and those of disproportions. The obtained solutions of the territorial-communication model are compared with a fractal standard, which serves as an indicator of the most effective urban organization in terms of the basic life support infrastructures and their communications. The algorithm makes it possible to reveal territorial disproportions of the urban environment, i.e., risk areas that violate the stability of the urban system as a whole and require external management.
Strategic Development of Venture Funds in Russia
Authors: Gavrilina Daria , Elkin Maxim
Published: November 2022

Venture funds are an element of the infrastructure that supports innovation. They make a significant contribution to the development of the national innovation system, as well as increase industrial competitiveness and high-tech production. This article describes the long-term strategic priorities for the developmentof domestic venture funds. The research relied on the method of regression analysis, as well as on the theoretical and practical concept of strategizing developed by Professor V.L. Kvint and adapted for the venture capital market. These methods made it possible to analyze the global and national strategic trends in the development of venture funds. The analysis of strategic documents provided a strategic assessment of the effect of venture capital and government R&D expenses on various indicators of the Russian economy. It also revealed the role of public and private fundings as strategic multipliers of innovative activity. The data obtained allowed the authors to formulate the strategic priorities for the development of venture funds in Russia.
Problemáticas bioéticas y biojurídicas asociadas a los proyectos de investigación
Authors: Arzuaga-Salazar María Angélica , Naranjo-Ramírez Gloria Patricia , Zuleta-Salas Guillermo León
Published: November 2022

Toda investigación debe estar orientada por principios Bioéticos. Investigación cualitativa, con enfoque de estudio de caso, con el objetivo analizar las problemáticas Bioéticas y Biojurídicas asociadas a los proyectos de investigación identificadas por los Comités de Ética de Investigación en salud en humanos. Participaron integrantes de Comités de Ética de Investigación en salud en humanos de Medellín y su Área Metropolitana; fueron realizadas entrevistas semiestructuradas, seguidas de análisis de contenido. Emergieron las siguientes problemáticas: debilidades en la validez científica y argumentación bioética de los protocolos de investigación; imprecisión de roles de los investigadores; vacíos y desactualización de la normatividad colombiana;  inadecuada valoración del riesgo, de la beneficencia y no maleficencia para los participantes; procesos de consentimientos informados inadecuados; coberturas inadecuadas de las pólizas; conflictos de interés de investigadores y de integrantes de los Comités de Ética de Investigación en salud en humanos. Se concluye que los Comités de Ética de Investigación en salud en humanos evalúan los proyectos buscando el equilibrio entre las políticas de investigación y los derechos de los participantes. El investigador debe reflexionar sobre los aspectos bioéticos y biojurídicos, prever situaciones eventuales en la investigación y las acciones para prevenirlas o resolverlas, aplicando el principio de precaución.
20 años formando profesionales de Enfermería con calidad académica y compromiso social
Authors: De la Cruz-Pabón Sheris , Acosta-Salazar Diana , González-Noguera Tatiana
Published: November 2022

El Programa de Enfermería de la Universidad del Magdalena cumple 20 años de formación académica. Es motivo de orgullo, reflexión y reconocimiento celebrar el nuevo aniversario de un programa que ha logrado destacarse a lo largo de las últimas dos décadas en el país y en la región caribe por su contribución a la sociedad, evidenciada en la formación de alta calidad que de sus egresados.
Effect of optimised infrared heat treatment on composition structure and gelation properties of cowpea protein isolate.
Authors:   UNIVERSITY OF JOHANNESBURG, OGUNDELE OPEOLUWA , OGUNDELE Oluwafemi ,   UNIVERSITY OF JOHANNESBURG, Ijabadeniyi Oluwatosin ,   Durban University of Technology
Published: November 2022

Infrared radiation heating is a heat pre-treatment method that employs infrared electromagnetic radiation to generate heat in pulses such as cowpea for the production of instantized ingredients and products. Optimum processing conditions, moisture content of 45%, the heating temperature of 185 „ƒ, and time of 5 min was reported to precooked cowpea from previous studies. Modified protein isolates are suitable for industrial use due to their improved functionality. In this study, the effect of optimised conditions (45% moisture, the heating temperature of 185 „ƒ, and heating time of 5 min) on the composition structure and gelation properties of protein isolated from cowpea seed was investigated. This was then analysed by amino acid profiling, hydrophobicity, FTIR and Intrinsic fluorescence emission in comparison with the untreated to define its potential application in the food system. Aspartic acid and glutamic acids were the major amino acids in the protein isolates from the optimised infrared heated cowpea compared to the untreated cowpea. Infrared heating induced a slight blue shift from 350 nm in the untreated cowpea to 347nm in the treated cowpea protein isolates indicating a more folded structure in the protein. This coincides with the hydrophobicity data. Particle size data revealed that the optimised infrared heated cowpea protein isolate body has multimodal particles while the untreated isolated cowpea protein has a bimodal particle size. The polydispersity index (PDI) of the infra-heated cowpea is below 0.3 indicating a homogenous particle size within the protein body. the Î²-sheet structure was dominant in both treated and untreated cowpea protein isolates. The dispersion of treated cowpea protein formed a structured network fluid. Infrared heating may improve the functional application of cowpea protein in industries.
Processing opportunities and challenges for plant-based proteins
Authors:   Iowa State University (ISU), Lamsal Buddhi , Byanju Bibek ,   Iowa State University
Published: November 2022

With demand for nutritious and functional protein-rich ingredients rising, there are opportunities to acquire protein from new/ emerging sources, as well as from coproducts of agro-food industry. Some of these sources include plants/ seeds and oilseeds, microalgae, fungi, cell/ microbial, and insect protein; however, each of these may have their own unique challenges in terms of extraction, nutritional profile, bioactivity, techno-functional properties, safety, allergenicity as well as in food and feed applications.            Some of the challenges for plant/seed proteins are that they have relatively lower extraction yields and relatively inferior functional/ nutritional aspects, including off-flavor and digestibility. Protein quality in defatted meals is also impacted by harsh oil removal process, which is further exacerbated by the downstream protein extraction and isolation conditions (pH, ionic strength, temperature etc.) resulting in protein denaturation, aggregation, and potential loss of functionality. Also, plant proteins have other issues such as off-flavors, astringency/ taste, allergenicity, and antinutritional factors that reduce mineral bioavailability and protein absorption. Various food processing techniques can be used to reduce/ remove these aspects of protein ingredients; fermentation, germination, heating, enzymatic, or acidic treatment, membrane separation etc. have been employed to improve protein purity and quality. The choice of processing technology, even for oil removal from oilseed, impacts protein extraction and quality. For example, protein recovered from meal/ fibers of aqueous oil extraction were of better quality than from desolventized meals.            Emerging physical and biochemical processes, such as high-power sonication, extrusion, high-pressure processing, microwave, pulsed electric field, enzymatic pretreatment (pectinase, proteinase, carbohydrase), and fermentation are reported to increase protein extraction efficiency, removing/ reducing allergenicity, and modify functional characteristics. This presentation will discuss such processing challenges and opportunities for plant-based proteins for extraction and downstream isolation, as well as their impact on important functional characteristics.