bluuebunny/crossref_metadata_2025 huggingface dataset:
A clinical study to evaluate the role of Kshara Karma in oral mucocele with Teekshna Pratisaraniya Apamarga Kshara
Authors: Gayathri KB  , Padma  , KM Sweta  , Dhyan Surendranath
Published: February 2023

Introduction: Mucoceles are the most common benign lesions of the oral cavity developing as a result of retention or extravasation of mucus from the minor salivary glands. There are various treatment modalities which include excision, laser ablation, cryosurgery, sclerotherapy, micro marsupialization, and intra-lesional injection of sclerosing agent or corticosteroid. Although surgery is widely used, it has several disadvantages such as bleeding, lip disfigurement and damage to adjacent ducts with further development of satellite lesions. Kshara being an Anusastra possessing Chedana, Bhedana, Lekhana, Pachana, Vilayana, Shodhana, Ropana, Shoshana and Stambhana Karmas will address all the difficulties faced during conventional ways of treatments. The current study was undertaken to introduce, validate and standardise novel, minimally invasive, para surgical approach towards the treatment of oral mucocele. Methodology: Teekshna Pratisaraniya Apamarga Kshara was prepared. Clinical study was conducted on 30 subjects diagnosed with oral mucocele. Ksharakarma was done. For statistical analysis of parametric values, Repeated period ANOVA test within the group and for non-parametric values, Friedman’s Test within the group were used. Result: The comprehensive analysis of all the results reveals that, all the parameters showed significant change both statistically and clinically with no side effects or complication. Discussion: Ksharakarma on oral mucocele acts by tissue necrosis, gradual sloughing off followed by healing of remnant ulcer with epithelialisation, which was found to be an effective, minimally invasive, para surgical management of oral mucocele without any complications.
A clinical trial to evaluate the efficacy of Katupila Arka in post operative fistulotomy wound
Authors: R Lakshmi  , KM Sweta  , Dhyan Surendranath
Published: February 2023

Post-operative fistulotomy wound is a surgically created wound for the better healing of fistulous tract. It is considered as the standard treatment modality for fistula in ano and is the most widely performed procedure. The healing of the fistulotomy wound is a challenging task as the chances of infection is more because of its contaminated nature. This can be related to Vrana in Ayurveda and can be managed. There is a need for drugs which have Vrana Shodhaka and Vrana Ropaka properties. Katupila (Securinega leucopyrus (Wild.) Muell) has all the above said properties due to the presence of various phytochemical agents. It’s having a broad spectrum anti-microbial activity. References from a previous work done on Katupila Kalka indicate that, it is effective for the management of diabetic wound. Keeping the practical difficulty in the preparation of Kalka on daily basis, Arka Kalpana is adopted as an alternate method here. Katupila Arka showed marked ulcer regression during the course of treatment than Povidone Iodine which could be attributed to Vrana Shodana and Ropana property. It renders Shodhana (Cleansing/ Purification) action by virtue of its Kashaya and Tikta Rasas, Laghu, Ruksha, Tikshna Gunas, Ushna Veerya and Katu Vipaka. Ropana (Tissue healing / Regeneration) by virtue of its Kashaya and Madhura Anurasa and overall, by Prabhava. Tannins, Flavonoids, Phenol, Saponins and Alkaloids are present in the trial drug which enhances the wound healing property.
A clinical study to evaluate the efficacy of Keechakadi Taila in Darunaka
Authors: N. K. Chandini  , Ravindra Angadi  , Ashok Kumar BN  , R R Geethesh  , Sandesh Kumar Shetty
Published: February 2023

Darunaka (dandruff) is a disorder mentioned under the spectrum of Shirokapalagata Roga/Kshudra Roga by various Acharyas. It is a Kapha-Vata predominant disorder of Shiro-Kapala (scalp), characterized by Kandu (itching), Kesha-Chyuti (hair fall), Keshabhumi-Rukshata (dryness of scalp) and Keshabhumi-Sphutana (scaling). Shiroabyanga (oil massage to scalp) with Keechakadi Taila is mentioned as a treatment modality for Darunaka by Vangasena. It contains Keechaka (Bambusa arundinaceace), Sarshapa Taila (mustard oil), Gomutra (cow’s urine) as ingredients.  In general all Tailas (oils) alleviates Vata-Dosha and does not aggravate Kapha-Dosha. It is Twak Prasadaka (nourishing), thus helping in treating the disease by Samprapthi Vighatana (breaking the pathogenesis). Though there are plenty of treatment options available for dandruff, there is no promising treatment in any of the allied sciences assuring its complete cure, avoiding recurrence. Thus with the aim to know the efficacy of Keechakadi Taila in treating Darunaka and also to know how effectively it can prevent/ reduce interval between recurrences of Darunaka the present study was carried out. The study showed statistically significant result in the management of Darunaka.
A clinical study to evaluate the effect of Dashamoola Hareetaki Avaleha in Tundikeri w.s.r to Chronic Tonsillitis
Authors: Prabhu Aiswarya , Sharashchandra R  , Nagaratna SJ  , Sandesh Kumar Shetty
Published: February 2023

Recurrent tonsillitis is commonly seen in children and this has many adverse effects on the normal growth and development of the child, missing of school days, economic burden of treatment etc. are few to name. About 30 million children develop tonsillitis with frequent exposure to bacterial and viral infections. The chronic tonsillitis wherein the tonsil gland gets inflamed and enlarged repeatedly, after treatment the size remains same though the inflammation subsides. This leads to obstruction in the throat both to airways as well as digestive tract. According to Ayurvedic classics, various internal medicines and procedures are advocated in the management of Mukharogas. In general, the drugs selected for treatment should have Lekhana, Shothahara, Pachana, Ropana, Rakthashambana and Vedanasthapana properties. One such polyherbal preparation is Dashamoolaharitaki Avaleha mentioned in Svayathu Chikitsa by Acharya Vagbhata, which is widely used in clinics for management of Tundikeri. In the present scenario scientific validation about the success of these treatments is required. Therefore an open label clinical study was designed to prove the effect of Dashamoolaharitaki Avaleha in Tundikeri. Materials and Methods: An open trial single group clinical study with minimum of 30 patients between the age group of 5 to 15 years with Tundikeri over a period of 30 days. Result: The clinical    study showed highly significant results in relieving the clinical signs and symptoms of Tundikeri. Discussion: The Dashamoolaharitaki Avaleha was found therapeutically effective and safe to be administered in children and the mode of action was elaborated to substantiate the results.
A clinical study in the management of Garbhini Chardi with Dhatripanaka w.s.r. to Emesis Gravidarum
Authors: Dharmista Patel  , Rachana H.V.
Published: February 2023

Background: Health of pregnant women is of at most importance. A series of physiological and psychological changes happen in different stage of women, some of them may end in discomfort and trouble. Ayurveda classics have mentioned Garbhini Chardi as one among the Vyakta Garbha Lakshanas, which can be correlated with emesis gravidarum. Emesis gravidarum is a worldwide common obstetrical problem seen in the first trimester in about 50% of pregnant women. In this condition nausea and vomiting tend to be the start in the morning and frequently continue throughout the day. Altered hormonal and immunological states are considered responsible for the initiation of the manifestations which is probably aggravated by the neurological factors. For such physiological alteration, if proper care is not given, it may lead to complication like tiredness, weight loss, etc. which may affect mother and growing fetus. Aim: To analyze the efficacy of Dhatripanaka in the management of Garbhini Chardi with special reference to Emesis Gravidarum. Method: A randomized open labelled controlled clinical study of two groups consisting 15 patient each in control and trial group. Results: Dhatripanaka was found to be effective in all subjective and objective parameters. Conclusion: Dhatripanaka and Tab. Doxinate is equally effective in Garbhini Chardi w.s.r. Emesis Gravidarum.
Clinical efficacy of Karanj Tail Yoni Pichu in the management of Shwetapradar w.s.r. to Leucorrhoea
Authors: Meenakshi Nagar
Published: February 2023

Background: Shwetapradar is one of the most common of all gynaecological complaints. Shwetapradar (Leucorrhoea) is a condition characterized with excessive white vaginal discharge. It may be thick or viscid and foul smelling if it is caused by some infections. Inflammation of the womb, displacement of the uterus following childbirth and general weakness along with lack of cleanliness or infections may result as leucorrhoea among young females. In our text Shwetapradar is described directly or indirectly in many Yonirogas as a symptom. In the present study we have used Karanj Tail Yoni Pichu with the aim to validate the directives of classics on parameters of a systematic and scientific research work. Aim: Aim of the study is to evaluate the effects of Karanj Tail Yoni Pichu in the management of Shwetapradar. Materials and Methods: The method adopted in present study is clinical, open study. This study was done on 15 patients selected from OPD, having complaints of leucorrhoea and who fits in inclusion criteria. Patients were given Karanj Tail Yoni Pichu. All the patients result were assessed subjectively and objectively. Conclusion: This can be made out from the study that Karanj Tail Yoni Pichu is having Kaphavatashamak, Krimighna, Kandughna, Shothahara, Yonidoshahrita, Vranasodhana, Vranaropana etc. properties which successfully control & cure Shwetapradar.
Effect of Trataka (A Yogic Cleansing Technique) on Post-Covid Cognitive Impairments in Elders
Authors: Sahana AU  , Vijaya Kumar PS
Published: February 2023

Background: People who have survived COVID-19 frequently complain of cognitive dysfunction, which has been described as brain fog. Early reports describing a dysexecutive syndrome after COVID-19 and has considerable implications for occupational, psychological, and functional outcomes. It is well known that elders may be particularly susceptible to cognitive impairment after critical illness. Trāṭaka (a yogīc cleansing technique) is one of the Yogā practices which is considered to improve cognitive functions. The objective of this study was to determine whether Trāṭaka practice enhances the cognitive functions of the post covid elderly subjects. Material and Methods: Thirty elders who had enrolled in a thirty days Trāṭaka practice program. Their age ranged between 60 and 80 years (group average ±S.D., 68.5±6.3 years). Those who have any chronic illness and mental illness, and those who are not willing to participate were excluded. Trāṭaka intervention is given for 30 days, 1hour/day. At baseline and following thirty days, all participants completed DLST and SLCT. Results: Trāṭaka intervention showed significant change in DLST scores, increase (P-value< 0.000) in total attempted score, significant increase (P-value<0.000) in net score, significant reduction in wrongly attempted score (P-value<0.000). Significant change in SLCT scores, significant increase (P-value<0.000) in total attempted score, Similarly, significant increase (P-value<.000) in net score, significant reduction in wrongly attempted score (P-value<0.000). Conclusion: The thirty days Trāṭaka intervention was successful in enhancing the cognitive functions among post-covid elders.
An observational clinico etiological study of Kushta with specific reference to Tinea corporis
Authors: Abhitha A  , Arunkumar M  , Nagaraj S  , Sandesh Kumar Shetty
Published: February 2023

Background: Skin diseases are among the most common health problems worldwide and are associated with considerable burden. In Ayurveda classics, skin disorders are termed in general as Kushta and are caused with involvement of Vata, Pitta, Shleshma and Krimi. Among the diversified etiological factors Krimi has a great importance. So, here an attempt is made to evaluate the clinical types, to isolate the common fungal species, etiological factors and to identify probable risk factors of Krimijanya Kushta in the present population. Objectives: To evaluate the clinical types, etiological factors and to identify probable risk factors of Krimijanya Kushta with special reference to Tinea Corporis and to isolate the prevalent causative fungal species. Materials and Methods: A total of 30 patients clinically diagnosed with tinea corporis and fulfilling the inclusion criteria were taken for the study. Results: Among 31 patients studied percentage of growth of different species of dermatophytes in culture study are given as follows, 48.4% are Trichophyton, 6.5% were Trichosporon, 3.2% were Microsporum Gypseum, 19.4% were Epidermophyton,16.1% were Candida, 3.2% were Aspergillus, 3.2% were found no growth. Conclusion: Aharaja and Viharaja Nidana mentioned in Kushta Nidana as well as Krimi Nidana were found to have Madhura, Amla, Lavana Rasa, Guru Guna, Vidahi, and Kledakaraka property which cause Swedaavarodha and is crucial for Kushta Utpathi as well as Krimi Utpatti. The prevalent causative fungal species found in the study were Trichophyton, Epidermophyton, Aspergillus, Trichosporon, Microsporum gypseum. Clinically to approach Kushta, better to be done through culture study.
A comprehensive study on Regional Anatomy of Adho Shaakhaagata Maamsa Marma by Cadaver Dissection and their Applied Anatomy
Authors: Rajath H Savanur  , Nithin Kumar  , Rashmi NR
Published: February 2023

Marma is the meeting point where Mamsa, Sira, Snayu, Asthi and Sandhi along with Prana resides which on injury produce death or death like miseries. Maamsa Marma is one such category based on predominant Marma Vasthu. They are eleven in number. Among them four are present in Adho Shakhaa i.e., two Talahrudaya and two Indrabasthi. Talahrudaya Marma is located in the middle of Paada in the line of middle finger, which on injury causes Ruja and Marana.  Indrbasthi Marma is located in the middle of Janghain the side of Paarshni and it causes death due to Shonitha Kshaya. Both of them are Kaalantarapraanahara Marmas. Methods: Literature regarding Marma and its Viddhalakshana were collected from various sources and its Viddha Lakshanas are analysed scientifically. Anatomical structures found in the region of Adhoshakhaagata Maamsa Marmas were confirmed with the help of cadaveric dissection in five bodies. Results: Muscles of 1st, 2nd, 3rd and 4th, layer of the sole, Medial & lateral plantar nerves, deep plantar arch, shielded by thick layer of skin, superficial facia and plantar aponeurosis are the important structures present in the Talahrudaya Marma Sthaana. Superficial & deep calf muscles, posterior tibial vessels, peroneal vessels, tibial nerve and short saphenous nerve are the important structures present in the Indrabasthi Marma Pradesha. The Viddha Lakshanas are analyzed with applied aspects of these regions. Conclusion: Centre of the sole along the line of middle finger can be considered as the region of Talahrudaya Marma which on injury results in Ruja & Marana. Indrabasthi Marma is located in the middle of the Jangha (calf) in the side of Paarshni (heel) about 12 Angula above heel, which on injury results in Shonitha Kshaya & Marana.
Experimental evaluation of Ardrakadi Ghritam for its Anti-microbial Activity
Authors: Vivek Raj R  , Chaitra LV
Published: February 2023

Background: Ardrakadi Ghrita mentioned in Sahasrayogam and its Anti-microbial activity was analyzed. Aim and objective: An experimental evaluation of Ardrakadi Ghrita for its Anti-microbial activity. Methods: Experimental evaluation of Ardrakadi Ghritam for its Anti-microbial activity against microbes such as Escherichia Coli and Klebsiella Pneumonia. Results: Determination of zone inhibition by Agar well diffusion method. For Test Organism are Escherichia Coli and Klebsiella Pneumonia. Inoculum: Cell suspension prepared from cultures grown on Trypsin broth adjusted to 1-2 x105cells/ml. Conclusion: From the experimental study the result it was found that Ardrakadi Ghrita not showed ant- microbial activity.
A controlled clinical trial to evaluate the efficacy of Shalaparnyadi Kwatha in the management of Vataja Grahani
Authors: Harshitha M  , V Rajendra
Published: February 2023

Background: Current mechanized life, irregular dietary patterns, irregularity in daily practices, junk food indulgence, stressful life, over usage of pesticides and chemicals leads to various gastro intestinal disorders. These factors hamper the digestive capacity of individuals and develop the disease Grahani. Shalaparnyadi Kwatha mentioned in treatment of Vataja Grahani in Sharangadhara Samhita is taken up for study in the management of Vataja Grahani. Objective: To evaluate the efficacy of Shalapanryadi Kwatha in Vataja Grahani. Method:  The study was a double arm open labelled controlled clinical trial with pre and post-test study design. There were total of 41 subjects involved in the study and were divided into two groups - Group A (trial group) with 21 subjects and Group B (controlled group) with 20 subjects. Group A was administered with Shalaparnyadhi Kwatha and Panchamooladya Choorna and Group B was administered with Panchamooladya Choorna for 30 consecutive days. Result: A controlled clinical study was conducted on subjects of Vataja Grahani with Shalaparnyadi Kwatha and Panchamooladya Choorna in trial group and Panchamooladya Choorna in control group both the interventions were effective in management of Vataja Grahani. Based on the mean value and statistically significant difference between the groups, trial group showed better result than control group in Amayukta Mala Pravrutti and Udara Shoola. Conclusion: It can be concluded from the results that added effect of Shalaparnyadi Kwatha with Panchamooladya Choorna is more effective than Panchamooladya Choorna alone.
A clinical study to evaluate the efficacy of Tekaraja Churna in the management of Tamaka Shwasa vis-a vis Bronchial Asthma
Authors: Shrikanta  , Mytrhey RC
Published: February 2023

Tamaka Shwasa is one among the five types of Shwasa. It is predominantly Kaphavataja Vyadhi originating from Pittasthana. Aggravated Vata leads to its Pratiloma Gati and enters Pranavaha Srotas afflicts the Kapha produces Peenasa, Ghurghuraka, Shwasakricchrata, Kasa, Pramoha, Parshvagraha, Vishuskasyata. This disease shows close resemblance with bronchial asthma. According to global initiative for asthma (GINA), asthma defined as a chronic inflammatory disorder of the airways which is associated with airway hyper responsiveness. It leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing particularly at night and in early morning. Asthma affects both children and adults. It is estimated that as many as 300 million people of all ethnic backgrounds suffer from asthma. Prevalence of asthma in india is 2.5-5.0%. In this present study, Tekaraja Churna mentioned in Sahasrayoga was selected for the management of mild to moderate grade bronchial asthma.
A comparative clinical trial to evaluate the efficacy of Darvyadi Kashaya and Vidangadi Kashaya in Prameha vis-a-vis Type II Diabetes Mellitus
Authors: Tejaswini D Bhat  , Sanjay Kumar MD
Published: February 2023

Background: Prameha is a Mutratipravrutta Vyadhi which is characterized by Prabhuta Mutra and Avila Mutra. Prameha is considered as a Daruna Vyadhi as it involves Tridosha, affects Basti which is a Mahamarma, is Anushangi with many Upadrava. Kapha, Meda and Shareera Kleda play an important role in its manifestation. This disease has closer resemblance with Type II Diabetes mellitus. In Ayurveda classical texts, various formulations in the form of Kashaya, Ghritha, Asava and Arishta have been explained in the context of treatment of Prameha. Darvyadi Kashaya and Vidangadi Kashaya mentioned as Sarvaprameha Hara Yoga in Charaka Samhita and Yogaratnakara respectively are taken up for study in the management of Prameha vis-a-vis Type II Diabetes mellitus. Objective: To compare the efficacy of Darvyadi Kashaya and Vidangadi Kashaya in Prameha vis-`a-vis Type II Diabetes mellitus. Method: It was a comparative clinical study involving two groups, Group A and Group B, each consisting of 25 patients. For Group A, Darvyadi Kashaya was administered and for Group B, Vidangadi Kashaya was administered for 90 consecutive days.  Result: After completion of treatment, it was observed that glycemic control was considerable in both the groups. Darvyadi Kashaya showed slightly better results in Karapada Daha and Prabhuta Mutra at night. In fresh cases, significant glycemic control was observed compared to treated cases in both the groups. Conclusion: It can be concluded from the results that both Darvyadi Kashaya and Vidangadi Kashaya are equally effective in management of Prameha vis-a-vis Type II Diabetes mellitus.
Clinical efficacy of Tila Taila Paada Abhyanga and Eye Exercises in the management of Timira w.s.r. to Simple Myopia
Authors: Zeba Afroz MB  , Mallikarjun S. Yalagond  , Asha V. Karki
Published: February 2023

As the world is heading into this new era of digitalization, it is also dragging itself into the valley of diseases and the most apparent and direct ill effect of it can be seen on the health of the eyes. The diseases of eyes are very prevalently emerging in today’s time owing to its multiple abundantly found causative factors like absence of following healthy lifestyle, unhealthy/ improper diet, excessive screen time etc. The most common among the diseases of eyes are the refractive errors. Uncorrected refractive error is reported as the first cause for visual impairment. WHO states that uncorrected myopia is the most common cause for visual impairment. Ayurveda, the Science of Life explicitly talks about the structure of Eye, its Diseases, and the various measures and medications used to preserve the health as well as cure the Diseases of Eyes. Paada Abhyanga is one among them. All the Bhrihatrayees have mentioned about the positive effect of Paada Abhyanga on Eyes i.e., as Drishtiprasaadaka. Eye Exercises well known to reduce the constant Stress of the Eyes caused due to Myopia can be effectively adopted in the management of Myopia.
In Vitro Anti-microbial effect of various extracts of Ġokṣura (Tribulus terrestris) fruits on common pathogens causing Urinary Tract Infection
Authors: Reetu Sharma  , Prof. Pawankumar Godatwar
Published: February 2023

Introduction: The present study was carried out with an objective to investigate the antimicrobial potentials of various extracts of Gokṣura (Tribulus terrestris Linn.) fruits on common uropathogen strains. Material and Methods: Aqueous, ethanol, chloroform, petroleum ether extracts of fruits of Tribulus terrestris were evaluated for potential antimicrobial activity against certain uropathogen strains. The antimicrobial activity was determined in the extracts using agar well diffusion method. The antibacterial activities of extracts (5%, 10% and 15% w/v) of Tribulus terrestris were tested against Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumonia and Enterococcus faecalis.   Zone of inhibition of extracts were compared with that of standard drug Azithromycin 1 % w/v (Positive control) and DMSO(Negative control) for antibacterial activity. Observations and Results: Inhibition of the bacterial growth was shown against the tested organisms in all extracts but ethanol extract at 15% concentration showed highest activity against all pathogens. The phytochemical analyses of the plants were also carried out which was found to be similar to standard values of API. Conclusion: The results of this study showed that Tribulus terrestris possesses significant antibacterial activity against common uropathogens.
A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF AZILSARTAN 40MG AND TELMISARTAN 40MG IN STAGE I HYPERTENSIVE PATIENTS ATTENDING CARDIAC OPD AT TERTIARY CARE HOSPITAL
Authors: MANJU M. SNEHA , MIRYALA SWATHI , RACHEL PERAVALI ARPANA , KUMAR K. MAHESH , LATHA GOURELLY
Published: February 2023

Objective: To study the efficacy and safety profile of Telmisartan 40 mg and Azilsartan 40 mg in stage I systemic Hypertension among patients attending cardiac OPD in a tertiary care center.
Methods: An open-labeled comparative study was conducted in the Department of Cardiology, Osmania General Hospital, Hyderabad, for 24 mo. All patients with stage I systemic hypertension of either sex, aged 18-65 y, with blood pressures of >140/90 mmHg and/or diabetes mellitus attending the cardiac outpatient department at Osmania General Hospital. After initial screening, diagnosed cases of essential hypertension were randomly allocated to either group 1 (Tablet Azilsartan 40 mg or group 2 (Tablet Telmisartan 40 mg). The patients were advised to report for follow-up for review on the 4th, 8th, 12th, and 24th week.
Results: The mean decrease in the systolic blood pressure in both groups was statistically significant with a P value of<0.05 at the 8th week, 12th week, and the end of the 24th week. The mean decrease in diastolic blood pressure in both groups was statistically significant with a P value of 0.01 at the end of the 24th week. The difference between the SBP and DBP at various intervals is statistically significant with an Anova P value of<0.0000001.
Conclusion: Both drugs controlled blood pressure at similar proportions. However, the mean of SBP and DBP for the Azilsartan group was lower than the Telmisartan Group. Both drugs were tolerated well, and no significant adverse effects were noted during the study.
A COMPREHENSIVE REVIEW OF KALMEGH'S BIOLOGICAL ACTIVITIES (ANDROGRAPHIS PANICULATA)
Authors: BHATNAGAR ANJU
Published: February 2023

Kalmegh is a valuable herb belonging to the family Acanthaceae that has been used traditionally in India and Southeast Asia to cure a variety of illnesses like diabetes, viral hepatitis, high blood pressure, ulcers, and malaria. It has many important bioactive compounds, such as diterpenoids, flavonoids, and polyphenols. The most common and abundant diterpenoid is andrographolide. It cures and prevents several diseases in humans. Andrographis and its extract have been documented for their various medicinal uses. A full bibliographic inquiry was conducted using extensively used scientific databases like Web of Science, research articles, and online as well as offline sources. A goal of the current review is to analyze the Andrographis paniculata's traditional usage, chemical components, and biological activities to highlight, explore, and lay the groundwork for future research.
EPIDEMIOLOGICAL PROFILE AND ASSOCIATION OF VARYING HABITS WITH PRECANCER AND OSCC IN POPULATION OF NORTH INDIA
Authors: TANDON DIVYA , RAJAWAT JYOTIKA
Published: February 2023

Objective: The pathologic appearances and clinical symptoms of Oral Premalignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCC) vary across different patient populations. This is possibly due to behaviours and cultural influences such as excess tobacco use. We aim to evaluate the epidemiological profile and clinical characteristics of OPMDs and OSCC in the North Indian population. Methods: This was a retrospective study of 600 subjects including 200 OSCC cases, 200 OPMDs and 200 matched controls. Medical records and clinical and histopathological diagnosis of OSCC and oral precancer patients were included. The data was analysed using SPSS. Results: Two third of the OSCC patients were males and one third were females and mean age of 48.5 y. Maximum incidence of total cases was observed in age groups from 30-70 y and was more in males. Buccal mucosa is found to be the most affected location (67%) in both men and women. We found a significant association between size of the tumor, the number of nodes involved, and degree of differentiation and gender. Significant association was observed between gender and tobacco use, pattern of smoking and alcohol consumption, while no association was observed with fluoride use by habit and gender. Significant results were found between prevalence of OSCC and OPMDs with chewing tobacco and pattern of smoking. Also, pattern of smoking was significantly associated with gender in OPMD and OSCC subjects. Conclusion: This study could help in educating the people and support the healthcare workers in implementing preventive measures against OPMDs and OSCC.
CHOICE OF MEDICAL PROFESSION-PASSION OR PRESSURE: MEDICAL STUDENTS PERSPECTIVES
Authors: RASHMI RAMANATHAN , JEEVITHAN SHANMUGAM , SRIDHAR MAGADI GOPALKRISHNA , KALANITHI THANEERPANDHAL PALANISAMY
Published: February 2023

Objective: Medical profession is one of the most aspired career option among school students and parents. Though the profession may look so lucrative and charming, one needs to be committed a lot to become a successful doctor. Passion and interest towards the career will be the most determining option to be a successful practitioner. But there will be many external influences in a student’s life to choose this career. This study was conducted with the objective to understand the factors that influenced MBBS students to choose this career.
Methods: An analytical cross-sectional study was conducted among 1060 MBBS students throughout India. A self-designed questionnaire which contained questions related to why they selected this career was prepared and validated among experts in the field and was converted into google forms and was circulated to all the medical colleges in India through social media platform.
Results: Though the majority (60.4%) mentioned that passion to serve as the main reason, nearly one-fourth (25.8%) have opted the career for social status, job opportunity, good remuneration and lifestyle. Nearly one-third (32%) have regretted joining the profession. Regarding the plan after MBBS, most of them (59.2%) preferred speciality practice. Clinical subjects were the most preferred Postgraduation.
Conclusion: Though passion for the medical profession was the most common reason for coming into this career, parental and few other external influences were also found as the reasons for choosing MBBS among some students.
ANTIDEPRESSANT-LIKE ACTIVITY OF METHANOLIC EXTRACT OF WITHANIA QARAITICA IN MICE
Authors: ALMAQBALI REEM KHALFAN , SHAIKH JAMALUDDIN , MOHAMMED WELI AFAF , SAID SADRI ABDULLAH
Published: February 2023

Objective: The goal of the present study was to assess the antidepressant-like action of Withania qaraitica in two behavioral animal models, the forced-swimming test (FST) and tail suspension test (TST) in mice.
Methods: Withania qaraitica methanolic extract was prepared by the maceration. The antidepressant activity was measured by the forced-swimming test (FST) using C57BL/6 mice and the tail suspension test (TST) using BALB/c mice. Mice were divided into three groups: control (DMSO), standard (citalopram and desipramine), and Withania qaraitica methanolic extract (n = 6 per group). Drugs were injected (1 ml/100 g) intraperitoneally (i. p.). Data were evaluated using analysis of variance, followed by LSD post-hoc tests, where *p<0.001 was considered significantly different from the vehicle control. The data are expressed as mean±SEM.
Results: In both the FST and the TST, antidepressant-positive controls citalopram and desipramine significantly reduced the time of immobility compared to vehicle control (p<0.001). The methanolic extract of Withania qaraitica at the dose of 40 mg/kg significantly reduced the immobility times with respect to vehicle control as well as lower doses of the same extract (10 and 20 mg/kg) in FST (p<0.001). In a similar fashion, the methanolic extract of Withania qaraitica at the dose of 40 mg/kg significantly decreased the duration of immobility in TST (p<0.005).
Conclusion: The current results show the antidepressant-like activity of Withania qaraitica in mice. This observation warrants additional studies to identify the underlining mechanism by which Withania qaraitica produces antidepressant-like effects.
EVALUATION OF CARICA PAPAYA LEAF EXTRACT IN PLATELET PROPAGATION FROM STEM CELLS
Authors: D. B. ADARSH , K. CHANDRA SAGAR , MURUGAIAN ELANGO E.
Published: February 2023

Objective: To evaluate the efficiency of Carica papaya extract in differentiating stem cells into platelets.
Methods: The bioactive compounds of C. papaya leaf extract were screened by biochemical and LCMS-MS methods. Mesenchymal stem cells (MSCs) were cultured with and without C. papaya leaf extract and observed for megakaryocyte-mediated platelet differentiation. The microscopy and flow cytometer analysis were performed from day 0 to day 12.
Results: The biochemical and LCMS-MS screening of C. papaya leaf extract confirmed the presence of alkaloids, saponins, glycosides, steroids, flavonoids, phlobatanins and anthracyanine. When treated with leaf extract (50µg), the MSCs differentiated into megakaryocytes and platelets.
Conclusion: The present study has shown the effect of C. papaya leaf extract in MSCs differentiating into platelets. Since the crude extract of the leaf was used, the bioactive compound(s) responsible for platelet production is yet to be confirmed.
Review on Comparative Analysis of Symmetrical, Unsymmetrical and Diagrid Multistory Building using Staad pro.
Authors: Solanki Suraj , Pareek Pragya
Published: February 2023

Abstract: This review paper involves the study of various aspects of analysis and design of multi storey residential building by using STAAD. Pro. Structural designing requires a detailed structural analysis on which the design of the structure is based. But it is not always possible to do in manual calculation hence the need for programming tools was found. For which several of power tools were formed, among which the most widely used one is STAAD.
Integration of Block chain Model for Energy Efficient WSN for IOT Application
Authors: Kushwaha Ruchi , Shambharkar Rohit , Gupta Suyash , Malik Monika
Published: February 2023

Abstract: Wireless Sensor Networks (WSNs) play a key role in the Internet of Sensor Things (IoST).IoST helps collect data from environments and is used in energy trading, monitoring, smart grids, and more. Connect to the Internet and automate your surveillance system without third-party involvement. An IoST network consists of Sensor nodes that perform environmental monitoring. Wireless Sensor Networks (WSN) and the Internet of Things (I.o.T) have gained popularity in recent years as the underlying infrastructure for connected devices and sensors in a variety of sectors. The data generated by these sensors are used in smart cities, agriculture, transportation systems, healthcare systems, toll collection systems, automatic identification of road data, automatic identification of vehicle license plates, and more. It has become a proposed blockchain mechanism. The main problems and challenges of WSN are effectively reduced by using the LEACH protocol with efficient cluster head selection.
Application of Machine Learning in Disease Prediction
Authors: Garg Ayush , Bansal Deepika
Published: February 2023

Abstract: Healthcare is a sector that is always changing. Healthcare professionals may find it challenging to stay current with the constant development of new technologies and treatments. As a result, the purpose of this research paper is to try and implement machine learning features in a specific system for health facilities. Knowing if we are ill at an early stage rather than finding out later is crucial. The entire process of treatment can be made much more effective if the disease is predicted ahead using specific machine learning algorithms as opposed to directly treating the patient. In this work, disease is predicted based on symptoms using machine learning. Machine learning algorithms like Naive Bayes, Decision Tree, Random Forest, and KNN are used to forecast the disease on the provided dataset. As you can see, there are numerous potential applications of machine learning in clinical care in the areas of patient data improvement, diagnosis, and treatment, cost reduction, and improved patient safety.
Analysis and Visualization of the Fluoride Hazard Quotient in the Groundwater of Rural Areas in Northwestern Region of Ajmer District, Rajasthan, India
Authors: Choudhary Rounak , Sharma Vivek , Mathur Praveen , Dutta Subroto
Published: February 2023

Abstract: Groundwater contamination by fluoride is a major concern in many regions of India. Fluoride in excess is one of the most harmful pollutants to human health. Water contains about 80% of the total fluoride acquired in the human body (mg/kg/day). The health risks connected with fluoride-rich ground water must be evaluated. Ajmer district (25°38'-26°58' N: 73°54'-75°22' E) covers an area of 8481 km2. The district's principal geomorphic characteristics include alluvial plains, linear ridges, pediment, denudation hill, buried pediment, and structural valleys. During this study, 15 villages in the northwestern district of Ajmer were sampled. The fluoride exposure dose, which is an individual's chronic daily absorption of fluoride by eating, was determined for infants, children, and adults; a hazard quotient greater than one suggests the possibility of detrimental health effects. The Hazard Quotient for fluoride in the research region was mapped using Inverse Distance Weighting (IDW) interpolation. The HQ analysis showed that all readings above the permissible limit of one, with values ranging from 1.01 for Pushkar to 4.38 for nearby Hokhra. The average fluoride value for the whole research region was 2.73, with a standard deviation of 0.950. Fluorosis appears to be caused mostly by fluoride-rich waterways in the region. Decomposition, dissociation, and dissolution are the primary chemical events responsible for fluoride mobility and transit into groundwater. Low-cost fluoride control strategies include mixing, artificial recharge, effective irrigation systems, and well construction.
AMATÖR SPOR KULÜPLERİ FEDERASYONU YÖNETİCİLERİNİN LİDERLİK YÖNELİMLERİ, KİŞİLİK ÖZELLİKLERİ VE EMPATİ DÜZEYLERİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: ÖZKAN Rıdvan , YAMAN Metin
Published: February 2023

Özet

Bu araştırmanın amacı Amatör Spor Kulüpleri Federasyonu yöneticilerinin liderlik yönelimleri, kişilik özellikleri ve empati düzeyleri arasındaki ilişkinin incelenmesidir. Bu amaç çerçevesinde araştırmanın evrenini Türkiye Amatör Spor Kulüpleri Konfederasyonu (TASKK) çatısı altında 81 ilde faaliyetlerini sürdüren Amatör Spor Kulüpleri Federasyonlarının (ASKF) 1027 yöneticisi oluştururken örneklem grubunu kolayda örnekleme yöntemi ile belirlenen 366 yönetici oluşturmaktadır. Katılımcıların liderlik yönelimlerini belirlemek için “Çok Yönlü Liderlik Yönelimleri Ölçeği”, kişilik özelliklerini belirlemek için “On-Maddeli Kişilik Ölçeği” ve empati düzeylerini belirlemek adına ise “Empati Düzeyi Belirleme Ölçeği” kullanılmıştır. Ölçme araçlarıyla toplanan verilerin analiz sürecinde SPSS 24 istatistik programından faydalanılmıştır. Analiz sürecinde verilerin frekans ve yüzde hesaplamasının ardından bağımlı ve bağımsız değişkenler arası etkileşim durumları çoklu regresyon analizi ile test edilmiştir. Açıklayan ve açıklanan değişkenler arasında doğrusal ilişki ise Korelasyon testi ile sınanmıştır. Araştırma sonucunda; Amatör Spor Kulüpleri Federasyonu yöneticilerinin kişilik özelliklerinin ve empati düzeylerinin Politik, İnsan Kaynaklı, Yapısal ve Karizmatik Liderlik yönelimlerinin yordayıcısı oldukları sonucuna ulaşılmıştır.
BEDEN EĞİTİMİ ÖĞRETMENLERİNİN METAVERSE BİLGİ DÜZEYLERİNİN ÇEŞİTLİ DEĞİŞKENLERE GÖRE İNCELENMESİ
Authors: TURAN Murat , MAVİBAŞ Muhammet , SAVAŞ Buğra Çağatay , ÇETİN Harun
Published: February 2023

Bu araştırma, beden eğitimi öğretmenlerinin metaverse bilgi düzeyleri tespit edilerek çeşitli değişkenler açısından karşılaştırılması amacıyla gerçekleştirilmiştir. Araştırmada ilişkisel tarama modeli uygulanmıştır. Araştırmanın evrenini Erzurum ilindeki okullarda görev yapan beden eğitimi öğretmenleri oluştururken, örneklem grubunu 136’sı erkek 21’i kadın olmak üzere 157 beden eğitimi öğretmeni oluşturmaktadır. Veri toplamak için katılımcıların demografik özelliklerini tespit etmek amacıyla araştırmacılar tarafından oluşturulan “Kişisel Bilgi Formu” ve beden eğitimi öğretmenlerinin metaverse hakkında bilgi düzeylerini belirlemek için ise Süleymanoğulları vd., (2022) tarafından geliştirilen 5’li Likert tip olan ve teknoloji, sosyal, dijitalleşme ve yaşam biçimi olmak üzere 4 alt boyut ve 15 sorudan oluşan “Metaverse Ölçeği” kullanılıştır. Beden eğitimi öğretmenlerinin demografik değişkenlerini tespit etmek amacıyla tanımlayıcı istatistik yapılmıştır. Katılımcıların cinsiyet, medeni durum ve metaverse terimini daha önce duyma durumlarına göre meteverse bilgi düzeylerini karşılaştırmak için T-Testi; yaş ve hizmet süresi değişkenine göre karşılaştırılmasında ise One-Way ANOVA testi uygulanmış olup anlamlılık düzeyi p=0,05 olarak belirlenmiştir. Katılımcıların cinsiyet ve hizmet sürelerine göre metaverse bilgi düzeylerinin karşılaştırılmasında anlamlı farklılıklara rastlanmamış (p>0,05); medeni durum, metaverse terimini duyma ve yaş değişkenine göre anlamlı farklılıklara rastlanmıştır (p
ÜNİVERSİTE ÖĞRENCİLERİNİN SPORA KATILMA VE KATILMAMA NEDENLERİNİN ARAŞTIRILMASI
Authors: GÖK Orhan , ÇİNGÖZ Yunus Emre
Published: February 2023

Çalışmanın amacı üniversite öğrencilerinin spora katılma ve katılmama nedenlerinin incelenmesidir. Araştırmaya farklı fakültelerde (Eğitim Bilimleri, Sağlık Bilimleri, Uygulamalı Bilimler, İnsan ve Toplum Bilimleri) eğitim hayatına devam eden 172’si erkek (137’si kadın olmak üzere toplam 309 üniversite öğrencisi gönüllü olarak katılmıştır. Araştırmada kapsamında öğrencilere birinci bölümde ‘’Kişisel Bilgi Formu’’, ikinci bölümde ‘’ Spor Yapma ve Yapmama Nedenleri Ölçeği’’ uygulanmıştır. Ölçeklerden elde edilen verilerin istatistiksel analizi için SPSS 26.0 bilgisayar programı kullanılmıştır. Betimsel istatistikler (frekans ve yüzdeler) hesaplanmış, yapma/yapmama nedenlerinin cinsiyet ve aylık gelir ile bağımsız olup olmadığı Ki-Kare testi ile gerçekleştirilmiştir. Anlam düzeyi olarak 0.05 seçilmiştir. Bulgulara bakıldığında Zinde kalabilmek ve zayıflamak için spor yapma ile cinsiyetin bağımsız olmadığı anlaşılmıştır (p
The Utility of Photobiomodulation as a Supplement to Orthobiologic Interventions
Authors: Hanney William , Rodriguez Juan , Wilson Abigail , Rothschild Carey , Kolber Morey , Varela Antonio , Salamh Paul
Published: February 2023

Several mechanisms may influence recovery and act as a complementary intervention to regenerative medicine. One area of consideration that may improve clinical outcomes in patients receiving regenerative medicine treatments is the utilization of supplementary interventions referred to as regenerative rehabilitation. One such intervention may be the use of light therapy also known as photobiomodulation (PBM). Terms synonymous with PBM include low-level light therapy (LLLT), low-power laser irradiation or cold laser. As a musculoskeletal intervention, PBM is administered via a mechanism that creates light through optical amplification. These interventions describe a form of PBM or light therapy that uses specific param-eters to target tissues through direct or indirect contact with or without heat or structural tissue alterations. PBM may improve treatment outcomes based on synergistic effects that are thought to modulate inflammation and facilitate cellular repair. This manuscript provides an overview of the current evidence supporting the use of PBM as a complementary intervention to regenerative medicine with a focus on managing conditions related to the musculoskeletal system.
Symposium in Motion - Addressing Dizziness. Navigating Possibilities in Collectives.
Authors: Ruth Anderwald  , Leonhard Grond  , Laura Brechmann
Published: February 2023

This process-oriented working symposium discusses ways of localizing, recognizing, approaching, and countering dizziness on different scales and disciplines – from the somatic and the built environment to interspecies and post-colonial contexts. Through the prism of art, architecture, philosophy, somatics, post-colonial theory, and remembrance cultures, we aim to find ways to uncover the layers of physical, social, and architectural dizziness in historical, political, social, fictional, present, and future contexts.
Effect of initial asymmetry in Magellanic penguin chick's performance. A cross-fostering experiment.
Authors: Marchisio Nahuel , Barrionuevo Melina , Frere Esteban
Published: February 2023

When chicks in a brood hatch asynchronously, the first to hatch gets fed
sooner, creating a hierarchy of asymmetries in the brood. In species
that suffer from brood reduction, this asymmetry can facilitate the
death of one chick during periods of low food availability. The aim of
this study was to analyze the effect of initial asymmetries on the
growth and survival of Magellanic penguin Spheniscus magellanicus
chicks, after disentangling the effects of parental condition, during
four breeding seasons. We manipulated chicks’ asymmetries within the
brood by performing a cross-fostering experiment, creating broods with
different weight ratios in a colony located in Isla Quiroga, Santa Cruz,
Argentina. We found that weight ratio determines the asymmetry within
the brood throughout the entire breeding season, and that final
asymmetry also depends on the study season. Chicks that hatch last have
a greater chance of survival when the weight ratio with their older
sibling is closer to 1. Parental body condition affects chick growth but
not asymmetry. To conclude, parents do not reverse the effect of initial
asymmetry in post-hatching stages, even during breeding seasons of high
reproductive success.
Os desafios da Criança com dificuldade de acesso Venoso e o uso de emicizumabe
Authors: Posener Araújo Elaine Cristina
Published: February 2023

A hemofilia seja ela A ou B é classificada como uma doença rara, geralmente éhereditária, ligada ao cromossomo X e por isso sua prevalência se manifesta em sua maioria nosexo masculino. É uma doença hemorrágica, ou seja, que impede a coagulação do sangue deforma efetiva e sua gravidade é classificada através da quantificação do percentual de fatorativo; dependendo da gravidade da doença o paciente hemofílico pode apresentarsangramento tanto pós trauma como espontâneos em qualquer lugar do corpo, sendo o maiscomum o sangramento intra-articular e muscular. Essa propensão a sangramentos afeta muitoa qualidade de vida do paciente juntamente com sua família. A cada dia vem surgindo maisestudos para introdução de novas terapias de tratamento para que o paciente tenha umaqualidade e expectativa de vida maior e melhor, sem tantos percalços na convivência com adoença.
Paciente em uso de emicizumabe - uma história de superação e sucesso
Authors: Casaretto Edilma
Published: February 2023

Hemofilia A é considerada uma patologia rara com gravidade e manifestação clínica variável,cujo tratamento e prevenção de sangramentos estão evoluindo desde a implementação daProfilaxia.