bluuebunny/crossref_metadata_2025 huggingface dataset:
New C‐3 Substituted 1H‐ and 2H‐Indazolephosphonic Acid Regioisomers: Synthesis, Spectroscopic Characterization and X‐Ray Diffraction Studies
Authors: Teixeira Fátima C. , Antunes Inês F. , Curto M. João M. , Duarte M. Teresa , André Vânia , Teixeira António P. S.
Published: September 2021

Indazole is known as an important structural motif in medicinal chemistry and, recently, has also gained attention in other areas, such as materials chemistry, with many studies showing different potential applications for their regioisomers. Phosphonates are also a class of compounds with diverse applications, ranging from medicinal to material applications. Here we present the synthesis of 1H‐ and 2H‐indazolephosphonic acid derivatives substituted at C‐3, involving mono‐ or bisphosphonic acids, from their corresponding carboxylic acid and esters. These compounds were fully characterized, and their spectroscopic data were evaluated to identify and distinguish the structural scaffold of each phosphonic acid. Crystallization of [hydroxy(1‐methyl‐1H‐indazol‐3‐yl)methanediyl]bis(phosphonic acid) 7 afforded crystals suitable for single crystal X‐ray diffraction studies and its crystal structure details are also discussed.
Facile Construction of Covalent Organic Framework Nanozyme for Colorimetric Detection of Uranium
Authors: Zhang Li , Yang Gui‐Ping , Xiao Sai‐Jin , Tan Quan‐Gen , Zheng Qiong‐Qing , Liang Ru‐Ping , Qiu Jian‐Ding
Published: September 2021

2D covalent organic frameworks (2D COFs) have been recognized as a novel class of photoactive materials owing to their extended π‐electron conjugation and high chemical stabilities. Herein, a new covalent organic framework (Tph‐BDP) is facilely synthesized by using a porphyrin derivative and an organic dye BODIPY derivative (5,5‐difluoro‐2,8‐diformyl‐1,3,7,9‐tetramethyl‐10‐phenyl‐5H‐dipyrrolo[1,2‐c:2′,1′‐f][1,3,2]diazabori‐nin‐4‐ium‐5‐uide) as monomers for the first time, and their unique photosensitive properties endow them excellent simulated oxidase activity under 635 nm laser irradiation that can catalyze the oxidation of 3,3′,5,5′‐tetramethylbenzidine (TMB). Further findings demonstrate that the presence of uranium (UO22+) can coordinate with imines of the oxidation products of TMB, thus modulating the charge transfer process of the colored products accompanied with intensive aggregation and remarkable color fading. This research provides a preparation strategy for COFs with excellent photocatalytic properties and nanozyme activity, and broadens the applications of the simple colorimetric methods for sensitive and selective radionuclide detection.
Development of an Acoustic Spot Data Communication System Using Multiple Parametric Array Loudspeakers
Authors: Taniguchi Yoshiaki , Morimoto Kohei
Published: September 2021

In this letter, we develop an acoustic spot data communication system using multiple parametric array loudspeakers, which are directional loudspeakers and can send audio in a specific direction. In our system, data are modulated and transmitted through multiple parametric array loudspeakers, and complete data reception is possible only at a specific spot. We implemented our system using low‐cost commercially available products and a self‐developed Java program, and we used frequency‐shift keying to modulate the acoustic data communication between the sender and receiver modules. Through comparative experimental evaluations, we show that data reception at a specific spot is possible using our system. © 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Political power and awareness of nursing during the COVID‐19 pandemic from the views of senior nursing students
Authors: Çatıker Aslıhan
Published: September 2021

Studying the impact of the COVID‐19 pandemic on the current nursing workforce and the training of future nurses is important. This study aimed to assess the views of senior nursing students pursuing health policy courses on the effects of the COVID‐19 pandemic on the political power and awareness of nursing profession. Document analysis method, one of the qualitative enhancement patterns, was employed in this study. This study was conducted in a nursing school with a sample comprising 34 nursing students. The data were collected from online homework documents and evaluated with thematic analysis. Students on the effects of the COVID‐19 pandemic on the nursing profession were categorized into three main themes and nine subthemes. Students reported that although the visibility of nursing increased during the COVID‐19 pandemic, the problems of this profession did not change. The results showed that depoliticization was an important obstacle in the fight against these problems and students stated that the struggle could be realized together with a unified and strong political voice. Students suggested being organized in the struggle against problems, addressing unions and associations, and political awareness and political participation as a remedy.
Features of X‐ray fluorescence determination of rock‐forming elements in powder samples of peat sediments
Authors: Amosova Alena A. , M. Chubarov Victor , L. Finkelshtein Alexandr
Published: September 2021

The features of rock‐forming elements determination in powder samples of peat sediments are considered. Based on theoretical calculations and experimental data, the mineralogical and particle size effects on the X‐ray fluorescence intensity have been estimated. For routine analysis, powder rock samples are usually milled to a particle size of 10–60 μm. Theoretically, estimated variations of rock‐forming elements analytical lines intensities in different minerals are up to 30%, and the particle size effect cannot be eliminated simultaneously for all rock‐forming elements. Experimental estimation shows that the impossibility of the particle size distribution control can lead to significant variations in the intensities of the analytical lines (3%–18%) that is mainly corresponding to theoretical estimation. Fine milling allowed us to achieve an average particle size of fewer than 20 μm and reduce the measurement uncertainty by 1.5–2 times. 12 samples of peat sediments with organic matter content up to 70 wt% were analyzed by X‐ray fluorescence analysis using different sample preparation techniques, as well as by certified methods. The accuracy of X‐ray fluorescence analysis of peat sediments prepared as pressed pellets varies from 1.5 to 11 rel% depending on compound contents. It is more than for samples prepared as fused beads, however, the proposed method can be used to determine the variations of rock‐forming elements contents in peat sediments where the content variations exceed the measurement uncertainty, and accuracy of analysis is sufficient for further paleoecological reconstructions.
God, Cosmos, and Humanity: Muslim Perspectives on Divine Providence
Authors: Rizvi Sajjad
Published: September 2021

The very notion of divine providence is inextricably linked to our conceptions of Islam. After a consideration of a more scripturally founded model of divine providence and indeed of how we might understand the reality of Islam, I will examine the dominant model for understanding divine providence articulated in the philosophical and theological traditions: the account in Avicenna and Mullā Ṣadrā in which providence explains how and why creation comes about and how we can explain the existence of evils. What are the implications of these historical models for us today in a world of even greater uncertainties, ambiguities, and randomness?
Causality, Indeterminacy, and Providence: Contemporary Islamic Perspectives from Said Nursi and Basil Altaie
Authors: Yazicioglu Isra
Published: September 2021

To understand divine providence, we need to understand the natural order and our place in it. Such inquiry leads to a rethinking of what we usually construe as explanation, especially the causal explanations we employ in everyday life and in modern science. Nursi and Altaie offer examples of how to do that rethinking. In light of cues from the Quran, they pay attention to empirical data and offer interpretations that are both intellectually and existentially compelling.
Randomness, Causation, and Divine Responsibility
Authors: Davison Scott A.
Published: September 2021

Many theists seem committed to the idea that God is responsible to some substantial degree for the occurrence of every contingent event. In this chapter, I explore questions about divine responsibility in cases of free human action and indeterministic processes in nature, with special attention to Michael J. Zimmerman’s work on the nature of shared responsibility.
Randomness and Providence: Defining the Problem(s)
Authors: Griffith Aaron M. , Naraghi Arash
Published: September 2021

In this chapter, we outline the various problems that ontological randomness is supposed to present to God’s providence, as understood by traditional monotheistic religions. We begin by defining various notions of randomness and identify putative examples. We then outline three conceptions of divine providence: Super Meticulous, Meticulous, and General Providence. We go on to articulate the problems that randomness is thought to pose for God’s providence, especially problems concerning God’s omnipotence, omniscience, and omnibenevolence. We explore how the different conceptions of God’s providence fare with respect to these problems and gesture toward some possible responses.
Chance, Evolution, and the Metaphysical Implications of Paleontological Practice
Authors: Love Alan C.
Published: September 2021

For several decades, a debate has been waged over how to interpret the significance of fossils from the Burgess Shale and Cambrian Explosion. Stephen Jay Gould argued that if the “tape of life” was rerun, then the resulting lineages would differ radically from what we find today, implying that humans are a happy accident of evolution. Simon Conway Morris argued that if the “tape of life” was rerun, the resulting lineages would be similar to what we now observe, implying that intelligence would still emerge from an evolutionary process. Recent methodological innovations in paleontological practice call into question both positions and suggest that global claims about the history of life, whether in terms of essential contingency or predictable convergence, are unwarranted.
Multi-track displaced vertices at B-factories
Authors: Acevedo Mason , Blackburn Albany , Blinov Nikita , Shuve Brian , Stone Mavis
Published: September 2021

Abstract

We propose a program at B-factories of inclusive, multi-track displaced vertex searches, which are expected to be low background and give excellent sensitivity to non-minimal hidden sectors. Multi-particle hidden sectors often include long-lived particles (LLPs) which result from approximate symmetries, and we classify the possible decays of GeV-scale LLPs in an effective field theory framework. Considering several LLP production modes, including dark photons and dark Higgs bosons, we study the sensitivity of LLP searches with different number of displaced vertices per event and track requirements per displaced vertex, showing that inclusive searches can have sensitivity to a large range of hidden sector models that are otherwise unconstrained by current or planned searches.
Hemodynamic evaluation of patients with Moyamoya Angiopathy: comparison of resting-state fMRI to breath-hold fMRI and [15O]water PET
Authors: Zerweck Leonie , Roder Constantin , Hauser Till-Karsten , Thurow Johannes , Mengel Annerose , Tatagiba Marcos , Khan Nadia , Meyer Philipp T. , Ernemann Ulrike , Klose Uwe
Published: September 2021

Purpose

Patients with Moyamoya Angiopathy (MMA) require hemodynamic evaluation to assess the risk of stroke. Assessment of cerebral blood flow with [15O]water PET and acetazolamide challenge is the diagnostic standard for the evaluation of the cerebral perfusion reserve (CPR). Estimation of the cerebrovascular reactivity (CVR) by use of breath-hold-triggered fMRI (bh-fMRI) as an index of CPR has been proposed as a reliable and more readily available approach. Recent findings suggest the use of resting-state fMRI (rs-fMRI) which requires minimum patient compliance. The aim of this study was to compare rs-fMRI to bh-fMRI and [15O]water PET in patients with MMA.

Methods

Patients with MMA underwent rs-fMRI and bh-fMRI in the same MRI session. Maps of the CVR gained by both modalities were compared retrospectively by calculating the correlation between the mean CVR of 12 volumes of interest. Additionally, the rs-maps of a subgroup of patients were compared to CPR-maps gained by [15O]water PET.

Results

The comparison of the rs-maps and the bh-maps of 24 patients revealed a good correlation (Pearson’s r = 0.71 ± 0.13; preoperative patients: Pearson’s r = 0.71 ± 0.17; postoperative patients: Pearson’s r = 0.71 ± 0.11). The comparison of 7 rs-fMRI data sets to the corresponding [15O]water PET data sets also revealed a high level of agreement (Pearson’s r = 0.80 ± 0.19).

Conclusion

The present analysis indicates that rs-fMRI might be a promising non-invasive method with almost no patient cooperation needed to evaluate the CVR. Further prospective studies are required.
Microbial 5′-nucleotidases: their characteristics, roles in cellular metabolism, and possible practical applications
Authors: Zakataeva Natalia P.
Published: September 2021

5′-Nucleotidases (EC 3.1.3.5) are enzymes that catalyze the hydrolytic dephosphorylation of 5′-ribonucleotides and 5′-deoxyribonucleotides to their respective nucleosides and phosphate. Most 5′-nucleotidases have broad substrate specificity and are multifunctional enzymes capable of cleaving phosphorus from not only mononucleotide phosphate molecules but also a variety of other phosphorylated metabolites. 5′-Nucleotidases are widely distributed throughout all kingdoms of life and found in different cellular locations. The well-studied vertebrate 5′-nucleotidases play an important role in cellular metabolism. These enzymes are involved in purine and pyrimidine salvage pathways, nucleic acid repair, cell-to-cell communication, signal transduction, control of the ribo- and deoxyribonucleotide pools, etc. Although the first evidence of microbial 5′-nucleotidases was obtained almost 60 years ago, active studies of genetic control and the functions of microbial 5′-nucleotidases started relatively recently. The present review summarizes the current knowledge about microbial 5′-nucleotidases with a focus on their diversity, cellular localizations, molecular structures, mechanisms of catalysis, physiological roles, and activity regulation and approaches to identify new 5′-nucleotidases. The possible applications of these enzymes in biotechnology are also discussed.

Key points

• Microbial 5′-nucleotidases differ in molecular structure, hydrolytic mechanism, and cellular localization.

• 5′-Nucleotidases play important and multifaceted roles in microbial cells.

• Microbial 5′-nucleotidases have wide range of practical applications.

Graphical abstract
Morphometric analysis of patella and patellar ligament: a cadaveric study to aid patellar tendon grafts
Authors: Aithal Padur Ashwini , Kumar Naveen , Lewis Melissa Glenda , Sekaran Varalakshmi Chandra
Published: September 2021

Purpose

Morphometric analysis of the patella and the patellar ligament is crucial in diagnosing and surgical corrections of knee injuries and patellofemoral joint disorders. Dimensions of the patella and the patellar ligament are frequently used in implant design and ACL reconstruction. This study aims to obtain detailed morphometric data on the patellar ligament and its localization based on gross anatomical dissections in the adult cadavers.

Methods

The present study consisted of 50 lower limbs from formalin-fixed male adult cadavers aged about 70 years (45–85) belonging to the South Indian population. Total length of the quadriceps tendon, patellar height, patellar ligament height, proximal width, distal width and thickness of the patellar ligament were measured meticulously. Mean, standard deviation, median scores of each parameter were computed for groups using SPSS 16.0. Level of significance was considered asp < 0.05. Wilcoxon signed-rank test was used to compare the various parameters on the right and left limbs. The relationships between all parameters were analyzed using Spearman’s rank correlation test.

Results

There was no statistically significant difference in the various measurements of the patella and patellar ligament between the right and left lower limbs. Patellar ligament length showed positive correlation with ligament thickness (r = 0.36;p = 0.078 for right limb andr = 0.33;p = 0.104 for left limb). Proximal width of ligament showed significant positive correlation with distal width (r = 0.41;p = 0.041 for right limb andr = 0.54;p = 0.006 for left limb).

Conclusion

This morphometric data and analysis might be fundamental in understanding various knee conditions in situ and necessary to orthopedic surgeons for successful planning and execution for ACL reconstruction using patellar ligament graft and other patellofemoral joint disorders.

Level of evidence

I
Venetoclax plus azacitidine and donor lymphocyte infusion in treating acute myeloid leukemia patients who relapse after allogeneic hematopoietic stem cell transplantation
Authors: Zhao Peng , Ni Ming , Ma Dan , Fang Qin , Zhang Yan , Li Yanju , Huang Yi , Chen Ying , Chai Xiao , Zhan Yun , Li Yan , Kang Qian , Zhao Mei , Liu Min , Zhang Fengqi , Huang Shisi , Wen Shuangshuang , Deng Bo , Wang Jishi
Published: September 2021

This study aimed to evaluate the efficacy and safety of venetoclax plus azacitidine and donor lymphocyte infusion (DLI) in treating patients with relapsed acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Twenty-six AML patients who relapsed after allo-HSCT were enrolled and treated with venetoclax plus azacitidine and DLI. Complete remission with incomplete recovery (CRi), partial remission (PR), and objective remission rate (ORR) were assessed, and then event-free survival (EFS) and overall survival (OS) were evaluated. Besides, adverse events were documented. Additionally, whole exome sequencing was performed in bone marrow samples. The CRi, PR, and ORR rates were 26.9%, 34.6%, and 61.5%, respectively. The median time of EFS and OS was 120 (95% CI: 71–610) days and 284.5 (95% CI: 81–610) days, respectively. The most common adverse events were hematologic system adverse events including agranulocytosis, anemia, and thrombocytopenia, while the adverse events of other systems were relatively less and milder. In addition, no serious adverse events existed. Of note, there were 6 (23.1%) patients who developed GVHD. As for gene mutation, 49 mutated genes were found, which were categorized as first-, second-, and third-class mutations, and then further analysis revealed that the first-class mutations were not correlated with EFS or OS. Additionally, the most frequent mutated genes were FLT3, CEBPA, DNMT3A, KIT, KRAS, and NRAS. Venetoclax plus azacitidine and DLI is efficient and tolerant in treating patients with relapsed AML after allo-HSCT, implying this combined therapy as a potential treatment option in the studied patients.
The NRW80+ study: conceptual background and study groups
Authors: Hansen Sylvia , Kaspar Roman , Wagner Michael , Woopen Christiane , Zank Susanne
Published: September 2021

Background

The study “Quality of life and well-being of the very old in North Rhine-Westphalia NRW80+” aims at giving a representative picture of the quality of life (QoL) in this population. Conceptually, QoL research has rarely considered the values of older individuals themselves and societal values, and their relevance for successful life conduct. Empirically, comparisons of different age groups over the age of 80 years are rare and hampered by quickly decreasing numbers of individuals in oldest age groups in the population of very old individuals.

Study design and theoretical framework

This paper describes the population of the NRW80+ study and different age groups of very old individuals with respect to biographical background. Furthermore, using the challenges and potentials model of QoL in very old age (CHAPO), key aspects of QoL in late life are discussed and the importance of normative stipulations of what constitutes a successful life conduct are highlighted. In the NRW80+ study older age groups (i.e., 85–89 years, 90+ years) were deliberately overrepresented in the survey sample to enable robust cross-group comparison. Individuals willing to participate in the study but unable to participate in the interview themselves for health reasons were included by means of proxy interviews.

The total sample included 1863 individuals and 176 individuals were represented by proxy interviews. Pronounced differences were observed between age groups 80–84 years (born 1933–1937, N = 1012), 85–89 years (born 1928–1932, N = 573), and 90 years or older (*born before 1927, N = 278) with respect to education, employment and the timing of major life events (e.g., childbirth).

Conclusion

Different life courses and resulting living conditions should be considered when discussing QoL disparities in very old age.
Financial burden and impact of atopic dermatitis out-of-pocket healthcare expenses among black individuals in the United States
Authors: Chovatiya Raj , Begolka Wendy Smith , Thibau Isabelle J. , Silverberg Jonathan I.
Published: September 2021

Black race is associated with increased atopic dermatitis (AD) severity and healthcare resource utilization. However, the burden of out-of-pocket (OOP) expenses among black individuals with AD is not well understood. We sought to characterize the categories and impact of OOP healthcare expenses associated with AD management among black individuals. A 25-question voluntary online survey was administered to National Eczema Association members (N = 113,502). Inclusion criteria (US residents age ≥ 18 years; self-report of AD or primary caregivers of individuals with AD) was met by 77.3% (1118/1447) of respondents. Black individuals with AD were younger, had lower household income, Medicaid, urban residence, poor AD control and frequent skin infections (P ≤ 0.02). Blacks vs. non-blacks reported more OOP costs for prescription medications covered (74.2% vs. 63.6%, P = 0.04) and not covered (65.1% vs. 46.5%, P = 0.0004) by insurance, emergency room visits (22.1% vs. 11.8%, P = 0.005), and outpatient laboratory testing (33.3% vs. 21.8%, P = 0.01). Black race was associated with increased household financial impact from OOP expenses (P = 0.0009), and predictors of financial impact included minimally controlled AD (adjusted OR [95% CI] 13.88 [1.63–117.96], P = 0.02), systemic therapy (4.34 [1.63–11.54], 0.003), > $200 monthly OOP expenses (14.28 [3.42–59.60], P = 0.0003), and Medicaid (4.02 [1.15–14.07], P = 0.03). Blacks with Medicaid had higher odds of harmful financial impact (3.32 [1.77–6.24], P = 0.0002) than those of black race (1.81 [1.04–3.15], P = 0.04) or with Medicaid (1.39 [1.02–1.88], P = 0.04) alone. Black race is associated with increased OOP costs for AD and significant household financial impact. Targeted interventions are needed to address financial disparities in AD.
Age-dependent gene expression of Calliphora vicina pupae (Diptera: Calliphoridae) at constant and fluctuating temperatures
Authors: Hartmann K. , Herrmann E. , Amendt J. , Verhoff M. A. , Zehner R.
Published: September 2021

Estimating the age of the developmental stages of the blow fly Calliphora vicina (Diptera: Calliphoridae) is of forensic relevance for the determination of the minimum post-mortem interval (PMImin). Fly eggs and larvae can be aged using anatomical and morphological characters and their modification during development. However, such methods can only hardly be applied for aging fly pupae. Previous study described age estimation of C. vicina pupae using gene expression, but just when reared at constant temperatures, but fluctuating temperatures represent a more realistic scenario at a crime scene. Therefore, age-dependent gene expression of C. vicina pupae were compared at 3 fluctuating and 3 constant temperatures, the latter representing the mean values of the fluctuating profiles. The chosen marker genes showed uniform expression patterns during metamorphosis of C. vicina pupae bred at different temperature conditions (constant or fluctuating) but the same mean temperature (e.g. constant 10 °C vs. fluctuating 5–15 °C). We present an R-based statistical tool, which enables estimation of the age of the examined pupa based on the analysed gene expression data.
Can Tanzania’s adaptation measures prevent future maize yield decline? A simulation study from Singida region
Authors: Volk Johanna , Gornott Christoph , Sieber Stefan , Lana Marcos Alberto
Published: September 2021

Cereal crop production in sub-Saharan Africa has not achieved the much-needed increase in yields to foster economic development and food security. Maize yields in the region’s semi-arid agroecosystems are constrained by highly variable rainfall, which may be worsened by climate change. Thus, the Tanzanian government has prioritized agriculture as an adaptation sector in its intended nationally determined contribution, and crop management adjustments as a key investment area in its Agricultural Sector Development Programme. In this study, we investigated how future changes in maize yields under different climate scenarios can be countered by regional adjusted crop management and cultivar adaptation strategies. A crop model was used to simulate maize yields in the Singida region of Tanzania for the baseline period 1980–2012 and under three future climate projections for 2020–2060 and 2061–2099. Adaptation strategies to improve yields were full irrigation, deficit irrigation, mulch and nitrogen addition and another cultivar. According to our model results, increase in temperature is the main driver of future maize yield decline. Increased respiration and phenological development were associated with lower maize yields of 16% in 2020–2060 and 20% in 2061–2099 compared to the 1980–2012 baseline. Surprisingly, none of the management strategies significantly improved yields; however, a different maize variety that was tested as an alternative coping strategy performed better. This study suggests that investment in accessibility of improved varieties and investigation of maize traits that have the potential to perform well in a warmer future are better suited for sustaining maize production in the semi-arid region than adjustments in crop management.
Climate risk and agricultural technology adaption: evidence from rice farmers in the Ayeyarwady River delta of Myanmar
Authors: Muraoka Rie , Furuya Jun , Hirano Akira , Sakurai Takeshi
Published: September 2021

Crop income can be raised in two ways: one way is to increase crop productivity and the other is to grow high-value crops that could be sold at high prices in the market. This study evaluated the adoption determinants of high-yielding varieties (HYVs) and high-value varieties (HVVs) of rice and their associations on crop income using data collected in coastal areas of the Ayeyarwady River delta, which is prone to climate shocks such as saltwater intrusion and cyclones. We used cross-sectional data on 298 rice-producing households and 393 rice plots to conduct multinomial logit estimates, which revealed that the heights of the plots, and past exposure to saltwater intrusion negatively affected the adoption of HVVs. Our estimates also suggest that while the adoption of HYVs is not associated with high rice yield, income, or profit, HVV adoption is associated with high income and profit.
Trigger poverty and reduplicative identity in Lakota
Authors: Paschen Ludger
Published: September 2021

This paper offers a phonological account of various ways in which reduplication interacts with independent processes in Lakota: transparent application in the case of cluster simplification, overapplication in the case of palatalization, and underapplication in the case of vowel mutation. I argue that all three patterns follow from phonological optimization rather than morpheme-specific constraints on the reduplicant or on other morphemes, and that the co-existence of divergent patterns is compatible with such a phonological analysis. Local application is the default pattern, while overapplication receives a cyclic explanation. For underapplication, which is the most recalcitrant pattern in Lakota, I offer an account in terms of Trigger Poverty, a concept which denotes an imbalance between the number of triggers and the number of potential targets created by copying. Trigger Poverty is likely to be a more general abstract source of underapplication beyond Lakota. This paper thus contributes to the discussion of modularity in phonology by presenting evidence that identity effects in reduplication can be epiphenomenal.
Social Integration of Second Generation Students in the Italian School System
Authors: Giovinazzi Francesco , Cocchi Daniela
Published: September 2021

Cultural divides and prejudice complicate the processes of integration and acculturation of migrant families living in a foreign country. Evaluating the impact of such phenomenon can be crucial for social stability and policy making. In this context, the education system has a leading role in fostering and attaining social integration, in particular when it comes to younger sections of the migrant population. In this work, we propose a method for the construction of a quantitative indicator capturing social integration of second generation students in the Italian school system according to areas defined by nationality of the students and administrative region in which they attend school. The indicator, based on survey data, is estimated by means of a 2-step methodology. In the first step, we choose an individual qualitative variable capturing social integration at the unit level, and we compute a first direct estimate of the indicator as the proportion of highly integrated students in each area. Such variable is isolated following alternatively a proxy variable approach or a latent variable model approach. In the second step, we make use of two alternative small area models to improve the estimates, dealing with missing values, low sample size and high variability in smaller domains. At the end, the 2-step methodology results in 4 alternative versions of a synthetic indicator of social integration, that can be used to rank nationalities and administrative regions.
Potential of Gold Nanoparticles for Noninvasive Imaging and Therapy for Vascular Inflammation
Authors: Kosuge Hisanori , Nakamura Maki , Oyane Ayako , Tajiri Kazuko , Murakoshi Nobuyuki , Sakai Satoshi , Sato Akira , Taninaka Atsushi , Chikamori Taishiro , Shigekawa Hidemi , Aonuma Kazutaka
Published: September 2021

Purpose

Macrophages contribute to the progression of vascular inflammation, making them useful targets for imaging and treatment of vascular diseases. Gold nanoparticles (GNPs) are useful as computed tomography (CT) contrast agents and light absorbers in photothermal therapy. In this study, we aimed to assess the viability of macrophages incubated with GNPs after near-infrared (NIR) laser light exposure and to evaluate the utility of intravenously injected GNPs for in vivo imaging of vascular inflammation in mice using micro-CT.

Procedures

Mouse macrophage cells (RAW 264.7) were incubated with GNPs and assessed for GNP cellular uptake and cell viability before and after exposure to NIR laser light. For in vivo imaging, macrophage-rich atherosclerotic lesions were induced by carotid ligation in hyperlipidemic and diabetic FVB mice (n = 9). Abdominal aortic aneurysms (AAAs) were created by angiotensin II infusion in ApoE-deficient mice (n = 9). These mice were scanned with a micro-CT imaging system before and after the intravenous injection of GNPs.

Results

The CT attenuation values of macrophages incubated with GNPs were significantly higher than those of cells incubated without GNPs (p < 0.04). Macrophages incubated with and without GNPs showed similar viability. The viability of macrophages incubated with GNPs (100 μg/ml or 200 μg/ml) was decreased by high-intensity NIR laser exposure but not by low-intensity NIR laser exposure. In vivo CT images showed higher CT attenuation values in diseased carotid arteries than in non-diseased contralateral arteries, although the difference was not statistically significant. The CT attenuation values of the perivascular area in AAAs of mice injected with GNPs were significantly higher than those of mice without injection (p = 0.0001).

Conclusions

Macrophages with GNPs had reduced viability upon NIR laser exposure. GNPs intravenously injected into mice accumulated in sites of vascular inflammation, allowing detection of carotid atherosclerosis and AAAs in CT imaging. Thus, GNPs have potential as multifunctional biologically compatible particles for the detection and therapy of vascular inflammation.
Validation and Psychometric Evaluation of the COVID-19 Risk Perception Scale (CoRP): a New Brief Scale to Measure Individuals’ Risk Perception
Authors: Capone Vincenza , Donizzetti Anna Rosa , Park Miriam Sang-Ah
Published: September 2021

The aim of the work was to develop and validate the COVID-19 Risk Perception Scale (CoRP), a brief self-report questionnaire for individuals’ perceptions of risk in the COVID-19 pandemic. Two studies were conducted in order to evaluate the new scale’s psychometric properties. Study 1 included 269 Italian participants (77.3% female) to initially test the scale’s structure and construct validity. Study 2 involved 1061 (76.2% female) Italians aged 18 to 80 years old and examined the structure of the scale, construct validity, and age invariance. Exploratory and Confirmatory factor analyses confirmed the one-factor solution, and the structure of the scale was found to be invariant across age groups. The scale also demonstrated a high internal reliability. The CoRP correlated positively with the fear of COVID-19 scale, and low with the Impact of Event and distressing phenomena as measured by GHQ. The present work thus affirms that the CoRP is a valid instrument for measuring individuals’ risk perception of COVID-19.
Evolution of the Non-metallic Inclusions Influenced by Slag-Metal Reactions in Ti-Containing Ferritic Stainless Steel
Authors: Wang Yong , Cho Jin-Hyung , Jeong Tae-Su , Karasev Andrey , Mu Wangzhong , Park Joo Hyun , Jönsson Pär G.
Published: September 2021

Laboratory experiment and thermodynamic calculation for the Ti-containing 24 mass pct Cr ferritic stainless steel with a CaO-SiO2-Al2O3-MgO system slag were performed to investigate the effect of slag addition on the inclusion characteristics in molten steel. The morphology, composition, and size evolution of inclusions in steel samples were analyzed in three-dimensional by the electrolytic extraction method and in two-dimensional by the automatic analysis method. The results showed that the Ti content significantly decreased after the slag addition. However, the change of the Si content showed an opposite tendency. The decrease of the Ti content in steel was due to the reduction of SiO2 and Al2O3 in the slag by dissolved Ti in steel. An increase of the TiO2 content in the slag can decrease the Ti loss in steel based on the slag-steel kinetic analysis. The total O content in the steel melt decreased from 62 to 26 ppm, and the steel cleanliness was improved, since the number density of inclusions decreased after the slag refining. The results of a kinetic analysis showed that the rate-determining step of the oxidation of Ti in the steel and the reduction of SiO2 in the slag were the mass transfer on the slag side. In addition, high Ti2O3-containing inclusions were found to be transformed to Cr2O3-Ti2O3-Al2O3 and Cr2O3-Ti2O3-SiO2 system inclusions after the slag addition. The Al2O3 contents in inclusions increased while the Ti2O3 contents decreased with time. However, there were some amount of high melting point inclusions with high Al2O3 content, which were not what we expected. When plotted on logarcxithmic scales, the mole ratio

$$X_{{{\text{Al}}_{2} {\text{O}}_{3} }} /(X_{{{\text{Ti}}_2 {\text{O}}_{3} }} \cdot X_{{{\text{Cr}}_{2} {\text{O}}_{3} }} )$$

X

Al
2

O
3

/

(

X

Ti
2

O
3

·

X

Cr
2

O
3

)

values of the inclusions were expressed as a linear function of the

$$a_{\text{Al}}^{2} /(a_{Ti}^{2} \cdot a_{\text{Cr}}^{2} \cdot a_{\text{O}}^{3} )$$

a

Al

2

/

(

a

Ti

2

·

a

Cr

2

·

a

O

3

)

values of the steel melts with a slope of unity, which was theoretically expected.
Current Treatment Options for Patients with Myotonic Dystrophy Type 2
Authors: Montagnese Federica
Published: September 2021

Purpose of the review

Myotonic dystrophy types 1 and 2 are frequent forms of muscular dystrophies in adulthood. Their clinical differences need to be taken into account for the most appropriate treatment of patients. The aim of this article is to provide an overview on the current and upcoming therapeutic options for patients with myotonic dystrophy type 2 (DM2).

Recent findings

At the moment, no disease-modifying therapies are available for DM2; next-generation therapies may however be available in the near future. In the meanwhile, the symptomatic management of patients has greatly improved, thank to the production of consensus-based standards of care and the growing evidence of efficacy of anti-myotonic drugs, promising employment of cannabinoids for symptom’s relief, regular monitoring, and early detection of treatable extra-muscular manifestations.

The treatment of DM2 is currently symptomatic and relies on the coordinated intervention of a multidisciplinary team. It remains to be determined whether upcoming causal therapies for myotonic dystrophy type 1 will be applicable also in DM2.
The Routine Follow-up Head CT: Is it Still a Necessary Step in the Thrombolysis Pathway?
Authors: Llinas Edward J. , Max Alexandra , Khan Sheena , Marsh Elisabeth B.
Published: September 2021

Background

The 24-h head computed tomography (CT) scan following intravenous tissue plasminogen activator or mechanical thrombectomy (MT) is currently part of most acute stroke protocols. However, as evidence emerges regarding who is at highest risk for treatment complications, the utility of routine neuroimaging for all patients has become less clear.

Methods

Four hundred seventy-five patients presenting with acute ischemic stroke to Johns Hopkins Bayview Medical Center between 2004 and 2018 and treated with intravenous tissue plasminogen activator and/or MT were evaluated. Neuroimaging performed during the first 48 h of hospitalization was reviewed for edema, hemorrhagic transformation (HT), or other findings altering management. Early imaging (< 24 h), performed for neurologic deterioration, was compared with imaging performed per protocol (24 ± 6 h). Factors predictive of radiographically and clinically significant findings on per-protocol imaging were determined.

Results

One hundred fifty-three patients (32%) underwent early imaging. These patients generally had more severe strokes. HT was found in 15% of cases. For the remaining patients (n = 322), imaging at 24 h impacted acute management for only 24 patients: resulting in emergent hemicraniectomy in 1 (0.3%) and leading to additional imaging to monitor asymptomatic HT or edema in 23 (7.1%). Advanced age, higher stroke severity, MT, and atrial fibrillation were associated with significant findings on the 24-h CT scan. Only 2 of the 24 patients had an initial National Institutes of Health Stroke Scale score of < 7.

Conclusions

The 24-h head CT scan does not change management for most patients, particularly those with low National Institutes of Health Stroke Scale scores who do not undergo MT. Consideration should be given to removing routine follow-up imaging from postthrombolysis protocols in favor of an examination-based approach.
Thinking with the Rain. The Trajectory of a Metaphor in Vygotsky’s Theoretical Development
Authors: Zittoun Tania
Published: September 2021

Vygotsky’s Notebooks edited by Zavershneva and Van der Veer (2018) give us a unique access to the inner-dialogue in which Vygotsky engaged while he was developing his theoretical work. In this paper, I propose to follow as “fil rouge” the semantic field associated to water, rain and clouds, and that will culminate as a “meteorological metaphor” through the Notebooks. Following the trajectory of this metaphor enables me to retrace the development of Vygotsky’s ideas about the dynamics uniting the planes of thinking and action, reality and inner life, affects and thinking. Doing so, I hope both to reflect on the role of a metaphor in the theoretical development of Vygotsky’s writings, and to highlight the potential and limits of his last series of theoretical explorations, which may inspire future work.
Mediating Knowledge Co-Production for Inclusive Governance and Delivery of Food, Water and Energy Services in African Cities
Authors: Sesan Temilade , Sanfo Safietou , Sikhwivhilu Keneiloe , Dakyaga Francis , Aziz Fati , Yirenya-Tawiah Dzidzo , Badu Mercy , Derbile Emmanuel , Ojoyi Mercy , Ibrahim Boubacar , Adamou Rabani
Published: September 2021

Rising rates of urbanisation in Africa, without attendant improvements in critical infrastructure, have occasioned gaps in the provision of basic services in cities across the continent. Different systems and scales of service delivery — decentralised and centralised, public and private — coexist and often compete in urban spaces but rarely connect in ways that ensure the needs of the poorest are met. Our paper interrogates the value of transdisciplinary research for bringing actors in these systems together to co-produce knowledge for inclusive and sustainable outcomes. Drawing on empirical data from two complementary projects in four African cities, we demonstrate the possibilities for facilitating this kind of knowledge co-production among system actors in the food, water and energy domains. We show, through a comparative approach, elements of the co-production process that enable more responsive engagement by traditionally detached policy actors. From our findings, we generate a framework that local researchers serving as ‘knowledge intermediaries’ can use to stimulate research-policy-society interactions aimed at fostering sustainable and inclusive service delivery across Africa. By synthesising the findings from local case studies into a widely applicable framework, our analysis informs both the theory and practice of transdisciplinary sustainability research in the African context where the imperative to bridge gaps in methodological innovation and service delivery is high.
Neuroparenting: the Myths and the Benefits. An Ethical Systematic Review
Authors: Snoek Anke , Horstkötter Dorothee
Published: September 2021

Parenting books and early childhood policy documents increasingly refer to neuroscience to support their parenting advice. This trend, called ‘neuroparenting’ has been subject to a growing body of sociological and ethical critical examination. The aim of this paper is to review this critical literature on neuroparenting. We identify three main arguments: that there is a gap between neuroscientific findings and neuroparenting advice, that there is an implicit normativity in the translation from neuroscience to practice, and that neuroparenting is a form of neoliberal self-management. We will critically discuss these arguments and make suggestions for ethically responsible forms of neuroparenting that can foster child development but avoid pitfalls.
Correction to: On a Problem of Pichorides
Authors: Bakas Odysseas
Published: September 2021

We provide a correction to the proof of [1, Theorem 19].
Differences between lung adenocarcinoma and squamous cell carcinoma in histological distribution of residual tumor after induction chemoradiotherapy
Authors: Nomori Hiroaki , Shiraishi Atsushi , Honma Koichi , Shoji Kazufusa , Otsuki Ayumu , Cong Yue , Sugimura Hiroshi , Oyama Yu
Published: September 2021

Aims

To facilitate dose planning for convergent beam radiotherapy in non-small cell lung cancer (NSCLC), tumor response and histological distribution of residual tumors after induction chemoradiotherapy (ICRT) were compared between adenocarcinoma (AD) and squamous cell carcinoma (SQ).

Methods

Ninety-five patients with N1–2 or T3–4 NSCLC were treated with ICRT followed by surgery; 55 had AD and 40 had SQ. For the evaluation of distribution of residual tumors, the location of the external margin of residual tumors was assessed on surgical materials as follows: radius of whole tumor (“a”); distance between the center of tumor and the external margin of residual tumor (“b”); and its location (“b/a”).

Results

Of the 55 AD cases, 8 (15%) showed pathological complete remission, which was significantly less frequent than 22 of 40 SQ cases (55%) (p < 0.001). AD showed the residual tumors at the most periphery of tumor (b/a = 1.0) more frequently than SQ, i.e., 39/55 (71%) versus 6/40 (15%), respectively (p < 0.001). Even in 65 cases other than the pathological complete remission, external margins in 47 AD cases located more periphery than those in 18 SQ cases, of which mean b/a values were 0.97 ± 0.17 and 0.70 ± 0.29, respectively (p < 0.001).

Conclusion

AD showed worse tumor response to ICRT than SQ. After ICRT, AD remained at the periphery of primary tumor more frequently than SQ. It seems that, also in the convergent beam radiotherapy, the periphery part of AD would be more resistant than that of SQ.
Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant
Authors: Branyan Taylor E. , Selvamani Amutha , Park Min Jung , Korula Kriti E. , Kosel Kelby F. , Srinivasan Rahul , Sohrabji Farida
Published: September 2021

MicroRNAs have gained popularity as a potential treatment for many diseases, including stroke. This study identifies and characterizes a specific member of the miR-17–92 cluster, miR-20a-3p, as a possible stroke therapeutic. A comprehensive microRNA screening showed that miR-20a-3p was significantly upregulated in astrocytes of adult female rats, which typically have better stroke outcomes, while it was profoundly downregulated in astrocytes of middle-aged females and adult and middle-aged males, groups that typically have more severe stroke outcomes. Assays using primary human astrocytes and neurons show that miR-20a-3p treatment alters mitochondrial dynamics in both cell types. To assess whether stroke outcomes could be improved by elevating astrocytic miR-20a-3p, we created a tetracycline (Tet)-induced recombinant adeno-associated virus (rAAV) construct where miR-20a-3p was located downstream a glial fibrillary acidic protein promoter. Treatment with doxycycline induced miR-20-3p expression in astrocytes, reducing mortality and modestly improving sensory motor behavior. A second Tet-induced rAAV construct was created in which miR-20a-3p was located downstream of a neuron-specific enolase (NSE) promoter. These experiments demonstrate that neuronal expression of miR-20a-3p is vastly more neuroprotective than astrocytic expression, with animals receiving the miR-20a-3p vector showing reduced infarction and sensory motor improvement. Intravenous injections, which are a therapeutically tractable treatment route, with miR-20a-3p mimic 4 h after middle cerebral artery occlusion (MCAo) significantly improved stroke outcomes including infarct volume and sensory motor performance. Improvement was not observed when miR-20a-3p was given immediately or 24 h after MCAo, identifying a unique delayed therapeutic window. Overall, this study identifies a novel neuroprotective microRNA and characterizes several key pathways by which it can improve stroke outcomes.