bluuebunny/crossref_metadata_2025 huggingface dataset:
Prestige does not affect the cultural transmission of novel controversial arguments in an online transmission chain experiment
Authors: Jiménez Ángel V. , Mesoudi Alex
Published: May 2019

Cultural evolutionary theories define prestige as social rank that is freely conferred on individuals possessing superior knowledge or skill, in order to gain opportunities to learn from such individuals. Consequently, information provided by prestigious individuals should be more memorable, and hence more likely to be culturally transmitted, than information from non-prestigious sources, particularly for novel, controversial arguments about which pre-existing opinions are absent or weak. It has also been argued that this effect extends beyond the prestigious individual’s relevant domain of expertise. We tested whether the prestige and relevance of the sources of novel, controversial arguments affected the transmission of those arguments, independently of their content. In a four-generation linear transmission chain experiment, British participants (N=192) recruited online read two conflicting arguments in favour of or against the replacement of textbooks by computer tablets in schools. Each of the two conflicting arguments was associated with one of three sources with different levels of prestige and relevance (high prestige, high relevance; high prestige, low relevance; low prestige, low relevance). Participants recalled the pro-tablets and anti-tablets arguments associated with each source and their recall was then passed to the next participant within their chain. Contrary to our predictions, we did not find a reliable effect of either the prestige or relevance of the sources of information on transmission fidelity. We discuss whether the lack of a reliable effect of prestige on recall might be a consequence of differences between how prestige operates in this experiment and in everyday life.
Threat Appraisals, Neuroticism, and Intrusive Memories: A Robust Mediational Approach with Replication
Authors: Mancini Anthony D , Aldrich Laura , Shevorykin Alina , Veith Serena , John Grace
Published: May 2019

Background: The appraisal of a stressor influences how we adapt to it. We used an experimental paradigm to test and replicate the effects of threat appraisals on subsequent intrusive memories, as well as their moderation by neuroticism. Method: In three studies (total N = 562; 77.6% female; mean age = 18.45), we randomly assigned participants to an aversive or control video, assessed threat appraisals of the video, and assessed intrusive memories of the video at one, three, five, and seven days. Results: Using a robust causal mediational framework, we found that threat appraisals fully mediated the effect of the video on intrusive memories (studies 1 – 3), and for people higher in neuroticism, the causal mediational pathway was stronger (study 1 and 2). Conclusions: These findings indicate threat appraisals have causal effects on subsequent intrusive memories and neuroticism enhances this effect, lending empirical support to appraisal theories of posttraumatic stress disorder.
Vagal suppression moderates the relationship between psychological flexibility and observed parenting in combat deployed fathers
Authors: Zhang Na , Hoch John , Gewirtz Abigail , Barnes Andrew , Snyder James
Published: May 2019

Vagal flexibility is a parasympathetic physiological indicator of emotion regulation and social engagement behaviors, often measured via heart rate variability (HRV). Experiential avoidance reflects psychological inflexibility or emotion dysregulation. We tested the influences of parental vagal flexibility and experiential avoidance on observed emotion-related parenting behaviors among combat deployed fathers. We analyzed data from 92 male National Guard/Reserve members who had been deployed to Iraq and/or Afghanistan since 2001 and recently returned. They were mostly White, in their 30s, middle-class, and married. All fathers participated in home-based assessments with their spouses (if married) and a target child aged between 4-13 years. Emotion-related parenting behaviors were observed during family interaction tasks using a macro-level coding system and quantified into four categories: positive engagement, withdrawal avoidance, reactivity coercion, and distress avoidance. Fathers’ vagal flexibility was measured as the change in cardiac vagal tone (i.e., high frequency HRV) from a neutral reading task to a father-child conflict resolution task. Experiential avoidance was self-reported. Results of multiple regression analysis showed no significant main effects of vagal flexibility on any observed parenting measures. There were significant moderation effects of experiential avoidance by vagal flexibility: among fathers with poorer vagal flexibility, a stronger relationship was found between experiential avoidance and emotion-related parenting behaviors (positive engagement and withdrawal avoidance), whereas among fathers with higher vagal flexibility, no such relationship was shown. These findings have implications for the linkage between emotion regulation and parenting in military fathers.
A Patient-Centered Perspective on the Future of Tic Disorder Diagnosis: Response to “Tic disorders revisited: Introduction to the term ‘tic spectrum disorders” by Müller-Vahl et al.
Authors: Conelea Christine , Jenkins Jaleesa , Brown Ben , Beljaars Laura
Published: May 2019

The paper, “Tic disorders revisited: Introduction to the term ‘tic spectrum disorders,” Müller-Vahl, Sambrani, and Jakubovski (2019) proposes a new diagnostic term “tic spectrum disorders” to encompass and replace diagnoses of Tourette Syndrome (TS), chronic tic disorder (CTD), and provisional tic disorder (PTD). This response raises three considerations as the future of tic disorder diagnostic terminology is debated, including the importance of engaging patient stakeholders, leveraging reappropriation as a stigma reducing strategy, and re-examining the exclusive focus on tics in diagnosis.
Which Positive Psychological Intervention would work for Osteoarthritis? A study identifying positive traits that are associated with physical and psychological well-being
Authors: Lau Lawrence C.M. , Chan Janice Wan Kam , Lau Hakwan , Fan Jason Chi Ho , Hung Yuk Wah , Cheng Joseph
Published: May 2019

Objective: Positive psychology interventions have been shown to be effective in improving psychological and physical wellbeing in general populations and patients with chronic pain. The goal of the current exploratory cross-sectional study is to identify psychological strengths that can be targeted in patient with osteoarthritis (OA) for subsequent development of positive psychology interventions.Methods: A consecutive 156 OA patients referred to a joint re- placement center participated in this study. They complete a questionnaire measuring their psychological strengths and emo- tional experience. Radiographs of knee were taken and physical examination of the knee were performed and also quantified with Knee Society Score and Oxford Knee Score.Results: Correlational analysis revealed that humour, a psycho- logical strength, is significantly correlated with both psychological (increased positive emotional experience) and medical (decreased perceived pain intensity) out- comes. In subsequent hierarchical regression analyses, we found that humour has significant incremental predictability even after controlling for the disease severity (radiographic Kellgren-Law- rence grading, range of movement, alignment, and knee scores), emotional experience, and demographical measurements .Conclusion: Our results are the first to show that people with high- er humour have less pain intensity, independent of clinical and radiological severity of knee osteoarthritis. This study suggests that humor could be a potential therapeutic target for chronic pain associated with knee osteoarthritis and further studies to investigate its biological pathway (like change in endorphins level) and using positive psychology interventions to cultivate humor in OA patients for pain relief are warranted.
The Individual True and Error Model: Getting the Most out of Limited Data
Authors: Schramm Pele
Published: May 2019

True and Error Theory (TET) is a modern latent variable modeling approach for analyzing sets of preferences held by people. Individual True and Error Theory (iTET) allows researchers to estimate the proportion of the time an individual truly holds a particular underlying set of preferences without assuming complete response independence in a repeated measures experimental design. iTET is thus suitable for investigating research questions such as whether an individual ever is truly intransitive in their preferences (i.e. they prefer a to b, b to c, and c to a). While current iTET analysis methods provide the means of investigating such questions they require a lot of data to achieve satisfactory power for hypothesis tests of interest. This paper overviews the performance and shortcomings of the current analysis methods in efficiently utilizing data, while providing new analysis methods that offer substantial gains in power and efficiency.
Reinforcing at the Top or Compensating at the Bottom? Family Background and Academic Performance in Germany, Norway, and the United States
Authors: Grätz Michael , Wiborg Øyvind N.
Published: May 2019

Research on educational mobility usually fails to consider variation in the association between social origin and academic performance across the distribution of children’s academic performance. However, theories of social mobility as well as theories about resource allocation within families predict such variation. We use quantile regression models to estimate variations in the associations between different indicators of family background (parental education, occupation, earnings, and wealth) and children’s educational performance across the performance distribution. We apply this approach to data on Germany, Norway, and the United States, three countries that represent different kinds of welfare and education regimes that may affect the intergenerational transmission of educational advantage. We find a stronger association between family background and academic performance at the bottom than in the middle and the weakest association at the top of the performance distribution. These findings are virtually identical across all four indicators of family background. We also find no cross-national differences in the variation of the association between family background and academic performance across the performance distribution.
Generalized ILVEN or Blaschkoid Psoriasis: A Persistant Dilemma
Authors: Kaushal Apurva , Gahalaut Pratik , Mishra Nitin , Rastogi Madhur Kant
Published: May 2019

A 24-year-old man presented with itchy verrucous, scaly red-brown papules, & linear plaques distributed in a blaschkoid pattern all over the body since last 20 years associated with itching. A skin biopsy was consistent with ILVEN (inflammatory linear verrucous epidermal nevus). Histopathologically, it can be difficult to distinguish it from linear psoriasis. It may respond to conventional anti-psoriatic therapies like potent topical corticosteroids applied under occlusion, or systemic treatments like acitretin.
Topical Corticosteroids Misuse: A Burning Issue
Authors: Neupane Saraswoti
Published: May 2019

Since the introduction of hydrocortisone into dermatology, a tremendous development has occurred in the field of topical corticosteroids. With the growing use of topical corticosteroids, a serious concern for its misuse is to be highlighted. This matter is of a great concern. Proper guidelines and legislation on the use of topical corticosteroids are warranted to combat this serious issue.
Role of Anti-oxidants in the Treatment of Vitiligo
Authors: Kumar Amit , Agrawal Sudha , Dhali Tapan Kumar , Majhi Shankar Kumr
Published: May 2019

Introduction: The role of free radicals and oxidative damage in the pathophysiology of vitiligo has been documented in recent studies. Antioxidant supplementation has been reported to be useful in the treatment of vitiligo.

Objective: To evaluate the role of oral antioxidants supplementation therapy in the treatment of vitiligo by assessing the onset of repigmentation and oxidative stress.

Materials and Methods: A total of 80 cases of vitiligo randomized into two groups: antioxidant and placebo comprising 40 patients each and were followed up for 8 weeks for the assessment of onset of repigmentation of vitiliginous lesions as primary outcome.  The activities of Malondialdehyde (MDA), Vitamin C, and Vitamin E in serum and of Catalase (CAT) in erythrocytes of patients at baseline and at end of eight weeks were also assessed by using the spectrophotometric assay.

Results: The onset of repigmentation was noted significantly earlier among the anti-oxidant group as compared to the placebo group (p=0.015). At the baseline, between the two groups, no significant difference was found in the different biochemical parameters. However, at the end of 2 months the level of MDA (p<0.001) was found to be significantly lower and that of Vitamin E (p<0.001) and CAT (p=0.005) was significantly higher among the anti-oxidants group as compared to the placebo group.

Conclusion: Antioxidant supplementation carried a better response in terms of early onset of repigmentation and significant decrease in the oxidative stress, in the short follow up of two months.
Spectrum of Dermatological Manifestations among Travelers Presenting at aTravel Medicine Center in Western Nepal
Authors: Gupta Sandeep , Pokhrel Saroj , Neupane Saraswoti , Pandey Prativa
Published: May 2019

Introduction: Skin disorders are among the most common reasons for travelers to seek medical care during and after travel. There is limited data on the spectrum of dermatoses reported among travelers during travel especially in South Asian continent.

Objective: To review the spectrum of skin disorder manifested among the traveler population attending a travel medicine hospital in western Nepal.

Materials and Methods: We performed a prospective study of the travelers visiting The Canadian International Water and Energy Consultants (CIWEC) Hospital, and Travel Medicine Center in Pokhara with history of skin disorders. This study was done from September 2014 until December 2015.

Results: A total of 130 (14.7%) patients presenting with dermatological manifestations were enrolled in the study.  The most common diagnoses were bacterial skin infections 0.4%, arthropod bites 3.6% followed by animal bites and skin laceration due to trauma,each were 12.1%. Among patients with bacterial skin and soft tissue infections, pus culture and sensitivity were recorded in 13 patients. In almost fifty percent of our sample Staphylococcus aureus growth was seen, of which 38.5% were Methicillin Resistant Staphylococcus aureus. 

Conclusion: Bacterial skin and soft tissue infections, arthropod bites and animal bites were common reasons for travelers to seek medical consultations during travel in Nepal. This information will be useful for the medicine professionals while taking care of travelers and also while providing pre-travel consultation to the prospective travelers.
Leprosy in Post Elimination Period: An Experience in a Single Tertiary Care Centre in Kathmandu, Nepal
Authors: Paudel Upama , Parajuli Sudip
Published: May 2019

Introduction:  Leprosy elimination was declared by Government of Nepal almost a decade back.

Objective: To evaluate the clinical and epidemiological profiles of leprosy patients in post elimination period

Material and Methods: Analysis of medical records of all clinically diagnosed and newly registered cases of leprosy attending Dermatology outpatient department of Tribhuvan University Teaching Hospital, Kathmandu, Nepal from 1st April 2017 to 31st March 2018 was done.

Results: Hospital based prevalence of Leprosy was found to be 0.24%, with males outnumbering females (63.6% vs 36.4%).The most common age group affected was 45-59 years  with hypo-aesthetic patches/plaques  and erythematous anaesthetic /hypoaesthetic patches (36.4% each) being  the most common presentation. Overall, borderline leprosy was the most common diagnosis (borderline tuberculoid ,29.5% , borderline borderline, 6.8%, borderline lepromatous,11.36%).  Slit skin smear positivity was found in  50% of cases.

Conclusion: Leprosy still remains a challenge for clinicians in Nepal though elimination has been achieved. A constant evaluation, monitoring and case detection should be still pursued with health education in order to make timely diagnosis and prevent deformities.
Pengambilan Keputusan Memilih Sekolah Dengan Metode AHP
Authors: Narti Narti - , Sriyadi Sriyadi , Rahmayani Nur , Syarif Mahmud
Published: May 2019

Setiap orang tua pasti ingin anaknya mendaftar pada sekolah yang tepat. Orang tua tidak ingin salah pilih dalam memilihkan sekolah untuk anak-anaknya. Dalam memilih sekolah yang baik dan tepat tentunya bukanlah suatu hal yang mudah, hal tersebut disebabkan karena banyaknya pertimbangan-pertimbangan yang dilakukan untuk mendapat suatu pilihan sekolah yang tepat, serta banyaknya pilihan sekolah yang membingungkan masyarakat baik siswa maupun orang tuanya. Adanya pendukung keputusan ini dapat menjadi solusi untuk memberikan pertimbangan dalam membantu masyarakat pada proses pemilihan sekolah. Metode Analytical Hierarchy Process (AHP) merupakan metode yang memiliki struktur yang berhirarki serta memberikan kemudahan dalam menyederhanakan suatu permasalahan dari kriteria yang kompleks dengan berbagai pilihan alternatif yang ada, sehingga dapat mempercepat proses pengambilan keputusan dalam pemilihan sekolah. Metode AHP ini mampu menghasilkan hasil yang lebih konsisten serta yang dihasilkan adalah berdasarkan urutan ranking dari setiap alternatif yang ada. Hasil perhitungan metode AHP ini terdapat empat kriteria yang menjadi tolak ukur dalam melakukan pemilihan sekolah yaitu, biaya, kualitas sekolah, tujuan akhir lulusan, serta bakat dan minat. Hasil akhir dari pengolahan data dan pengujian metode AHP didapatkan bahwa Sekolah Menengah Atas (SMA) lebih unggul 0,373 atau 37,3% sedangkan Sekolah Menengah Kejuruan (SMK) 0,370 atau 37,0%, Madrasah Aliyah (MA) 0,257 atau 25,7%.  Kata Kunci: AHP, Sekolah, Memilih, Keputusan
The influence of Mo/B atomic ratio on microstructural evolution and mechanical properties of Mo2FeB2-based cermets
Authors: Zhang Jiajie , Zheng Yong , Zhou Wei , Zhang Guotao , Ke Zheng , Dong Zuowei , Lv Xuepeng
Published: May 2019

Mo2FeB2-based cermets were prepared with various Mo/B atomic ratios in the range of 0.8 to 1.1. The microstructure and crystalline phases were studied through scanning electron microscopy, transmission electron microscopy, scanning transmission electron microscopy, energy dispersive X-ray analysis and X-ray diffractometry. The results indicated that as the Mo/B atomic ratio increased, the morphology of the hard phase gradually transformed from long-strip to near-equiaxed. The tendency of transformation in the range of 1.0 to 1.1 was more significant. Two typical cermet samples (Mo/B = 1.0, Mo/B = 1.08) of different morphologies were studied with transmission electron microscopy. As the Mo/B atomic ratio increased, the average particle size decreased, inhibiting the nucleation of the particles, the anisotropy of different crystallographic planes reduced, the particles transformed from long-strip to the near-equiaxed shape. Moreover, it could be found from X-ray diffractometry results that the disparity between the crystal lattice constants c and a gradually diminished and the surface tension differences of the amorphous surfaces decreased, resulting in the anisotropy of different crystal-lographic planes gradually decreasing. The cermets with Mo/B = 1.02 demonstrated the highest transverse rupture strength, as well as the hardness and improved fracture toughness values of 2367.5 ± 50 MPa, 88.2 ± 0.1 HRA, and 27.6 ± 0.5 MPa · m1/2, respectively.
Análise do Comportamento e desenvolvimento da linguagem
Authors: Almeida Christiana , Coutinho de Alcantara Gil Maria Stella
Published: May 2019

A Análise do Comportamento conta com suporte teórico e empírico para explicar o desenvolvimento e a aprendizagem da linguagem? Para responder à questão, foram sumarizadas quatro perspectivas teóricas analítico-comportamentais sobre a aquisição e o desenvolvimento da linguagem: comportamento verbal; comportamento simbólico; teoria da nomeação; teoria das molduras relacionais. Este estudo teve por objetivo apontar convergências e divergências entre as perspectivas teóricas e apresentar algumas implicações para a realização de estudos empíricos com participantes crianças de até 36 meses, usualmente chamadas de crianças pequenas. Desde a proposta skinneriana de análise do comportamento verbal, houve avanços nas teorias que pretenderam preencher lacunas na explicação do desenvolvimento e aquisição inicial da linguagem. Argumenta-se que é necessário dar continuidade a pesquisas que descrevam a aquisição precoce de repertórios verbais e simbólicos das crianças, em contexto experimental e no ambiente natural, para dar o necessário suporte empírico às formulações teóricas.
Ускладнення пункційної вертебропластики
Authors: Яворський О А , Ломакін А М , Свєтлицький В П
Published: May 2019

Мета. Покращити результати пункційної вертебропластики як методу мінімально інвазивного лікування больового синдрому при травматичних та патологічних переломах хребта.

Матеріали та методи. Виконано аналіз результатів лікування хворих в Університетській клініці ОНМедУ за період з 2013 по 2018 рік. Загалом проаналізовано випадки лікування 134 хворих та виконання вертебропластики 214 хребців. З приводу гострої травми лікувалися 21 хворих (23 хребці), з приводу патологічних переломів на фоні остеопорозу проліковано 58 хворих (104 хребці), з приводу пухлинного ураження хребта – 55 хворих (87 хребців). Післяопераційний контроль виконувався інтра- та післяопераційно за допомогою флюороскопії з використанням С-дуги і, на наступний день після операції, методом комп`ютерної томографії. Виконано аналіз кількості й структури післяопераційних ускладнень та їх вплив на якість життя хворих за шкалами ВАШ (візуальна аналогова шкала болю) та FIM (functional independence measure scale). Також виконано порівняльний аналіз специфічності методів рентгенологічного контролю екстравертебрального розповсюдження полімеру (кісткового цементу).

Результати. Жодне з виявлених ускладнень не мало суттєвого клінічного впливу на перебіг захворювання. Кількість випадків екстравертебрального розповсюдження цементу, що не проявлялись клінічно, які були виявлені під час комп’ютерної томографії, значно перевищувала рентгенологічні дані. В порівнянні: 18,7 % та 4,7 % випадків ускладнень виявлені за допомогою комп’ютерної томографії та рентгенографії. Єдиний випадок емболії дрібних гілок легеневої артерії був виявлений випадково під час післяопераційного дослідження грудного відділу хребта.

Висновки. Аналіз літературних даних та власних отриманих результатів дозволяє пропонувати використання комп’ютерної томографії в післяопераційному періоді, як найбільш чутливого методу діагностики післяопераційних ускладнень пункційної вертебропластики.
Випадок епізодичної пароксизмальної гемікранії. Особливості диференційної діагностики
Authors: Білошицький В В
Published: May 2019

Чоловік, 28 років, звернувся на консультацію зі скаргами на напади інтенсивного нестерпного (VAS 10) головного болю, які турбують з 19-річного віку. Зі слів пацієнта, тривалість нападів болю – 15–30 хвилин, частота протягом доби – 2–3 вдень і 4 вночі, в тому числі 2 напади виникають в один і той самий час – о 2-й годині ночі та о 7–8-й годині ранку. Останній напад піднімає пацієнта від сну. Серії нападів можуть виникати до 2 разів на рік, найчастіше в кінці весни або в кінці осені. Тривалість серії нападів може становити від 2–3 днів до 3 місяців, проміжки між серіями нападів (ремісії) можуть становити від 5 місяців до 2–3 років. Під час попередніх серій біль турбував у правій скроневій ділянці, правому оці, ділянці правої вилиці та верхньої щелепи справа. Під час нападів відзначає почервоніння ока, сльозотечу, відчуття закладання правої половини носа. Остання серія нападів почалася за 2 тижні до консультації, при цьому болі змістилися в ділянку лівої скроні й лівого ока (біль поміняв сторону – це буде прокоментовано окремо). Під час нападів збуджений (ажитація). Не палить зараз і не палив у минулому. Прийом алкоголю може посилити больові відчуття. Пацієнт повідомив, що в минулому через нестерпність болю була спроба самогубства.

Неврологічно: без особливостей. На представлених МРТ головного мозку відзначається вогнище лікворної щільності розмірами 0,9 × 1,9 × 1,8 см у правій скронево-лобовій ділянці конвекситально (розміри без динаміки), нерівномірно розширені конвекситальні підпавутинні простори, одиничне вогнище гліозу в правій лобовій ділянці.
Improvement of complex treatment of patients with osteoarthritis combined with hypertension
Authors: Kuznecova L P , Bondar M V
Published: May 2019

Actuality: Among the diseases that significantly affect people, osteoarthritis (OA) takes 4th place in women and 8th in men. In both sexes older than 70 years, osteoarthrosis occurs in almost everyone, and in the last decade its prevalence has steadily increased. The social significance of OA is determined by the increase in disability, especially in older age groups, as well as by a sharp decline in the quality of life for this.

Objective: To evaluate the efficacy of the therapy performed 12 months after initiation of treatment in patients with hypertension (GC) on the background of treatment with meloxicam at a dose of 7.5 mg/day and 80 and 160 mg/day.

Material and methods: under supervision in an outpatient setting, there were 90 patients on the OA 1–2 stages, in combination with GC 2 degree, 2–3 degrees. The average age of patients with OA was 64.4 ± 7.5 years (the first group), patients with OA in combination with GC – 62.13 ± 8.2 years (second group), patients with OA in combination with GC and gastropathy due to admission NSAIDs (third group) – 64.81 ± 1.3 years.

Disease duration in patients of the first group – (9.66 ± 4.7) years, in patients of the second group – (9.4 ± 6.0) years, in patients of the third group – (10.4 ± 5.6) years, respectively, the fourth group of comparison contained practically healthy persons.

All patients complained of pain syndrome of varying degrees of severity. Patients in the first group received baseline therapy of meloxicam at a dose of 7.5 mg/day; patients in the second and third groups received meloxicam and antihypertensive drug (at a dose of 80 or 160 mg per day). Duration of treatment was 12 months.

Results of the study and their discussion: according to the results, the positive effect of the use of meloxicam has led to a significant decrease in the severity of pain in the first, second and third groups according to the visual analogue scale (VAS): (27.8 %, 29.8 %, 25.4 %, p < 0.05) and the Lequesne index (27.1 % and 30.9 %, 26.4 %, p < 0.05), respectively.

Conclusions:

The tested scheme of treatment of patients with OA with the use of meloxicam indicates the efficacy and statistically significant reduction of pain syndrome, improvement of the functional state of the musculoskeletal system in patients with OA as well as with OA in combination with GC.

2.Also, the analgesic and anti-inflammatory effect of meloxicam and its positive effect on the clinical course of OA were revealed: joint pain decreased, functional capacity increased, general well-being and quality of life of patients improved. Prospects for further research: We consider it expedient to continue prospective surveillance of patients with the aim of further studying of the effect of meloxicam in patients with a comorbid disease.

Conflict of Interest: There is no conflict of interest.
Мікросудинна декомпресія при рецидивах класичної тригемінальної невралгії після перкутанних втручань на трійчастому вузлі
Authors: Набойченко А Г , Федірко В О
Published: May 2019

Актуальність. Процедури перкутанної ризотомії (ПР) в лікуванні класичної тригемінальної невралгії (КТН), за своєї достатньої ефективності, мають значний відсоток не-вдач та рецидивів болю. Вибір іншого втручання дуже складний, оскільки дані щодо лікування рецидивів КТН обмежені.

Мета дослідження. Дослідити, чи впливають раніше проведені перкутанні втручання на ефективність та безпечність “золотого стандарту” лікування КТН – мікросудинної декомпресії (МСД).

Матеріали та методи. Ретроспективний аналіз 28 послідовних випадків проведення МСД з приводу рецидиву КТН після ПР за період 2015–2016 рр. Категоризація даних та статистична обробка. Контрольна група 66 МСД у пацієнтів з КТН без будь-яких попередніх процедур. Використовувались шкали BNI для болю (BNI PS) та заніміння (BNI NS).

Результати дослідження та їх обговорення. Інтраопераційні знахідки: атрофія та деколорація трійчастого нерва – в 9 випадках (32 %); щільні арахноїдальні злуки з деформацією корінця – в 13 випадках (46,7 %); “молочне” помутніння павутинної оболони – в 5 (17,8 %); в одному випадку конфлікт не виявлено (3,6 %). Середній після-операційний бал за шкалою BNI PS склав 2,21 і статистично не відрізнявся від контрольної групи – 1,95. Під час останнього контролю бал BNI PS був нижчим у групі виключно МСД (1,43 проти 2,43; P = 0,0006; 95 % ДІ 0,5918–1,9987). BNI NS та інші показники нейропатії були вищими в групі ПР (2,5 проти 1,3; P < 0,0001; 95 % ДІ 0,6697–1,6541). Серед них 100 % мали клінічно суттєву нейропатію та 57 % мали дизестезії, на відміну від 27 % та 7 % відповідно в групі виключно МСД . Поява або погіршення симптомів нейропатії спостерігались у 5 пацієнтів (17,9 %). Додаткові ризики розвитку нейропатичних проявів ймовірно обумовлені деструктивним характером перкутанних втручань.

Висновки. Процедура МСД, як більш патогенетично обґрунтована, лишається втручанням вибору для пацієнтів із рецидивами КТН після раніше проведених ПР. Результати у цієї категорії пацієнтів гірші, ніж після пер-винної МСД.

Перспективи подальших досліджень. Багатоцентрові  дослідження  з  мультифакторним аналізом великих масивів даних.

Конфлікт інтересів. Відсутній.
Профілактика ускладнень перкутанної вертебропластики
Authors: Полковніков О Ю , Тяглий С В , Євченко Т І , Савченко Є І , Ізбіцька Н В , Локтенко Є Д
Published: May 2019

Перкутанна вертебропластика – один із широко застосовуваних у практиці малоінвазивних методів хірургічного лікування; найнебезпечнішим ускладненням вертебропластики є вихід акрилового цементу в хребтовий канал.

Мета дослідження: оптимізація техніки перкутанної вертебропластики для профілактики можливих ускладнень.

Матеріали та методи. Проведено аналіз результатів лікування 112 пацієнтів, що перебували на лікуванні у відділенні нейрохірургії КУ “ЗОКЛ” ЗОР з 2017 по 2019 рр. Усім пацієнтам було проведено пункційну вертебропластику. У 10 випадках при позиціонуванні пункційної голки не проводилася контрастна спондиловенографія. В інших спостереженнях після позиціонування пункційної голки в тілі хребця проводилася контрастна спондиловенографія, при наявності виходу контрасту за межі тіла хребця проводилася репозиція голки або при неможливості уникнути виходу контрасту вертебропластика не проводилася – 2 спостереження; при ознаках “швидкого” венозного дренажу вертебропластика виконувалася з експозицією в часі.

Результати дослідження та їх обговорення. Серед усіх пацієнтів було 80 жінок і 32 чоловіки. Серед жінок було 16 молодого віку (25–44 роки), 26 середнього віку (45–60 років) і 38 літнього віку (61–75 років). Серед чоловіків було 20 молодого віку, 4 середньо-го віку і 6 літніх. За типом патології випадки розподілилися наступним чином: “агресивні” гемангіоми – 94, патологічний злам тіла хребця на тлі остеопорозу – 8, мієломна хвороба – 2, травматичний злам тіла хребця – 4 випадки і в 4-х спостереженнях – метастатичне ураження. За локалізацією: грудний відділ хребта – 40, попереково-крижовий відділ хребта – 66 та множинне ураження (г.в.п. + п.к.в.п.) у 6-ти випадках. В 1 спостереженні відзначався гіпотензивний синдром. Серед 10 випадків, у яких не застосовувалася контрастна контрольна спондиловенографія, в 1 відзначено міграцію цементу в хребтовий канал.

Висновки: У профілактиці ускладнень пункційної вертебропластики велику роль відіграє відбір пацієнтів, а також контрастна спондиловенографія, яка дозволяє прогнозувати міграцію акрилового цементу в хребтовий канал.
La démocratie organisationnelle autrement
Authors: Jaumier Stéphane , Daudigeos Thibault , Huault Isabelle , Pasquier Vincent
Published: May 2019

Le présent article s’intéresse aux entreprises en tant que lieux possibles d’adoption de pratiques démocratiques radicales. Pour cela, les auteurs s’appuient sur la notion de « hiérarchie à domination inversée », qui caractérise des organisations dans lesquelles la structure hiérarchique est paradoxalement mise au service de l’égalité et de la démocratie. L’étude ethnographique d’une coopérative de salariés leur permet de décrire l’ethos égalitaire, les pratiques d’endiguement du pouvoir et les fonctions atypiques des manageurs propres à ce type d’organisations.
L’influence de la GRH mobilisatrice sur l’innovation
Authors: Ait Razouk Abdelwahab
Published: May 2019

Cette recherche se propose de comprendre les mécanismes intermédiaires qui expliquent la relation entre la GRH et l’innovation. Pour cela, les auteurs ont examiné l’effet médiateur du partage des connaissances. Les résultats issus d’analyses de régression logistique réalisées sur un panel de 962 établissements français de l’enquête REPONSE montrent une relation positive entre la GRH mobilisatrice et l’innovation. Toutefois, ce lien direct est impacté par l’introduction de l’indice de partage des connaissances dans les modèles de régression. En effet, le partage des connaissances joue un rôle de médiation entre la GRH et l’innovation.
Quelles compétences favorisent l’appropriation d’une écostratégie ?
Authors: Barbat Guillaume , Andre Jean-Marc
Published: May 2019

Cet article traite de l’enjeu environnemental dans une perspective appropriative. Une étude qualitative, menée dans le secteur de la grande distribution, envisage l’appropriation d’une écostratégie comme un processus d’apprentissage organisationnel mobilisant six compétences individuelles. Cinq dispositifs de gestion sont également proposés pour favoriser l’activation de ces compétences.
Václav Šmejkal (ed.): Evropská unie po brexitu: Právně-institucionální aspekty evropské integrace
Authors: Antal Jarolím
Published: May 2019

Odchod Velké Británie z Evropské unie je tématem, o kterém se diskutuje apíše z mnoha hledisek. Skupina autorů z Právnické fakulty UniverzityKarlovy si vybrala perspektivu zaměřenou na právně-institucionální aspektynejen odchodu Velké Británie z EU, ale i dalšího vývoje evropské integracebez jednoho z jejích dosavadních klíčových aktérů.

Autoři se v jednotlivých kapitolách zaměřili na velmi konkrétní oblastipůsobení EU, jako je volný pohyb osob, dohled nad finančním systémem,mezinárodní ochrana lidských práv atd. Tato témata rozebírají nejens ohledem na aktuální stav jednání o brexitu na jaře 2018 a záměrně se takévyhýbají „věštbám“ o budoucí podobě EU. V jednotlivých kapitolách najdečtenář hluboké zamyšlení nad samotnými institucionálními základy EU,jejich silnými a slabými stránkami a nad tím, co může sama EU i její občanéudělat pro to, aby myšlenka evropské integrace překonala krizi vyvolanouodchodem Velké Británie.

V závěru knihy každý z autorů odpovídá na následující otázky: KamEvropská unie po brexitu směřuje? Kde bude za osm až deset let? Jakétendence v ní převládnou? Které vnitřní problémy musí vyřešit, aby výzvupředstavovanou brexitem úspěšně překonala?
Tadpole morphology of the white-eyed toad Leptobrachium leucops Stuart, Rowley, Tran, Le & Hoang 2011 (Anura: Megophryidae) in Bidoup – Nui Ba National Park, Lam Dong province
Authors: Le Duong Thi Thuy , Tran Loan Thi Cam , Huynh Anh Vu Hong , Tran Dao Thi Anh
Published: May 2019

We describe the tadpole morphology of the white-eyed megophryd, Leptobrachium leucops Stuart, Rowley, Tran, Le & Hoang 2011 based on specimens originating from Bidoup – Nui Ba National Park, Lam Dong Province, Vietnam. The description is based on larva in developmental stages 25 - 41, which were bred at the University of Science, Vietnam National University-Ho Chi Minh City. Tadpoles of Leptobrachium leucops live in slow-flowing water - benthic with the body color from brown-black to black. Body oval shape in lateral view, dorsolaterally positioned eyes. Spiracle sinistral and leftlateral positioned. Vent tube medially located at body end, ventrally positioned. Oral disk ventrally positioned and bordered by a papillae row, in general, the keratodont row formulae of the is 1(5+5)/(4+4)1. Body length and oral disk width increase during developmental stages while tooth density decreases gradually and disappeare at the stage of 41.
Studying the Specific Activity of the Amide Form of HLDF-6 Peptide using the Transgenic Model of Alzheimer’s Disease
Authors: Bogachouk A. P. , Storozheva Z. I. , Telegin G. B. , Chernov A. S. , Proshin A. T. , Sherstnev V. V. , Zolotarev Yu. A. , Lipkin V. M.
Published: May 2019

The neuroprotective and nootropic activities of the amide form (AF) of the HLDF-6 peptide (TGENHR-NH2 ) were studied in transgenic mice of the B6C3-Tg(APPswe,PSEN1de9)85Dbo (Tg+) line (the animal model of familial Alzheimers disease (AD)). The study was performed in 4 mouse groups: group 1 (study group): Tg+ mice intranasally injected with the peptide at a dose of 250 g/kg; group 2 (active control): Tg+ mice intranasally injected with normal saline; group 3 (control 1): Tg- mice; and group 4 (control 2): C57Bl/6 mice. The cognitive functions were evaluated using three tests: the novel object recognition test, the conditioned passive avoidance task, and the Morris water maze. The results testify to the fact that the pharmaceutical substance (PhS) based on the AF of HLDF-6 peptide at a dose of 250 g/kg administered intranasally efficiently restores the disturbed cognitive functions in transgenic mice. These results are fully consistent with the data obtained in animal models of Alzheimers disease induced by the injection of the beta-amyloid (A) fragment 25-35 into the giant-cell nucleus basalis of Meynert or by co-injection of the A fragment 25-35 and ibotenic acid into the hippocampus, and the model of ischemia stroke (chronic bilateral occlusion of carotids, 2VO). According to the overall results, PhS based on AF HLDF-6 was chosen as an object for further investigation; the dose of 250 g/kg was used as an effective therapeutic dose. Intranasal administration was the route for delivery.
Mauritian Endemic Medicinal Plant Extracts Induce G2/M Phase Cell Cycle Arrest and Growth Inhibition of Oesophageal Squamous Cell Carcinoma in Vitro
Authors: Rummun N. , Hughes R. E. , Beesoo R. , Li W. W. , Aldulaimi O. , Macleod K. G. , Bahorun T. , Carragher N. O. , Kagansky A. , Neergheen-Bhujun V. S.
Published: May 2019

Terrestrial plants have contributed massively to the development of modern oncologic drugs. Despite the wide acceptance of Mauritian endemic flowering plants in traditional medicine, scientific evidence of their chemotherapeutic potential is lacking. This study aimed to evaluate the in vitro tumor cytotoxicity of leaf extracts from five Mauritian endemic medicinal plants, namely Acalypha integrifolia Willd (Euphorbiaceae), Labourdonnaisia glauca Bojer (Sapotaceae), Dombeya acutangula Cav. subsp. rosea Friedmann (Malvaceae), Gaertnera psychotrioides (DC.) Baker (Rubiaceae), and Eugenia tinifolia Lam (Myrtaceae). The cytotoxicities of the extracts were determined against six human cancer cell lines, including cervical adenocarcinoma, colorectal carcinoma, oesophageal adenocarcinoma, and oesophageal squamous cell carcinoma. The potent extracts were further investigated using cell cycle analysis and reverse phase protein array (RPPA) analysis. The antioxidant properties and polyphenolic profile of the potent extracts were also evaluated. Gas chromatography mass spectrometry (GC-MS) analyses revealed the presence of (+)-catechin and gallocatechin in E. tinifolia and L. glauca, while gallic acid was detected in A. integrifolia. L. glauca, A. integrifolia, and E. tinifolia were highly selective towards human oesophageal squamous cell carcinoma (KYSE-30) cells. L. glauca and E. tinifolia arrested KYSE- 30 cells in the G2/M phase, in a concentration-dependent manner. RPPA analysis indicated that the extracts may partly exert their tumor growth-inhibitory activity by upregulating the intracellular level of 5AMP-activated kinase (AMPK). The findings highlight the potent antiproliferative activity of three Mauritian endemic leaf extracts against oesophageal squamous cell carcinoma and calls for further investigation into their chemotherapeutic application.
Pengaruh Pelatihan dan Supervisi terhadap Prestasi Kerja Dimediasi Variabel Etos Kerja Guru pada SMP Negeri Gondang 2 Mojokerto
Authors: Sholihin Anwar
Published: May 2019

Kepala sekolah perlu mendorong para gurunya agar mempunyai prestasi kerja yang tinggi dengan harapan memperoleh banyak keuntungan bagi sekolah, namun tidak membuat guru merasa dirugikan. Kondisi ini sangat dipengaruhi oleh peran seorang pemimpin dalam organisasi, supervisi dan pengembangan guru. Tujuan dari penelitian ini adalah : 1) Untuk mengetahui dan menganalisis pengaruh pelatihan terhadap etos kerja guru. 2) Untuk mengetahui dan menganalisis pengaruh Supervisi terhadap etos kerja guru. 3) Untuk mengetahui dan menganalisis pelatihan terhadap prestasi kerja. 4) Untuk mengetahui dan menganalisis pengaruh Supervisi terhadap prestasi kerja. 5) Untuk mengetahui dan menganalisis pengaruh etos kerja guru terhadap prestasi kerja. 6) Untuk mengetahui dan menganalisis pelatihan terhadap prestasi kerja dimediasi variabel etos kerja guru. 7) Untuk mengetahui dan menganalisis pengaruh Supervisi terhadap prestasi kerja dimediasi variabel etos kerja guru. Berdasarkan pada pertimbangan waktu, tenaga, dan dana, serta ruang lingkup permasalahan dan banyaknya jumlah subjek dalam populasi yang jumlahnya 336 orang, maka penelitian ini menggunakan rumus slovin dengan signifikasi (p) (0,1) sehingg ditentikan sampel sehumlah 79 orang. Dimana seluruh anggota populasi dijadikan sampel, alat analisis data menggunakan software SmartPLS versi 3.3.7. Dari hasil penelitian dapat disimpulkan sebagai berikut: 1) Pelatihan berpengaruh signifikan terhadap Etos kerja guru 2) Supervisi tidak berpengaruh terhadap Etos kerja guru 3) Pelatihan tidak berpengaruh terhadap Prestasi kerja 4) Supervisi berpengaruh signifikan terhadap Prestasi kerja 5) Etos kerja guru tidak berpengaruh terhadap Prestasi kerja 6) Pelatihan berpengaruh secara tidak langsung terhadap Prestasi kerja melalui Etos kerja guru 7) Supervisi berpengaruh secara tidak langsung terhadap Prestasi kerja melalui Etos kerja guru
Pengaruh Penggunaan Media Pembelajaran Interaktif Berbantuan Video Online terhadap Kemampuan Berpikir Kritis Mahasiswa Pada Mata Kuliah Bahasa Arab Semester III di STIT Raden Wijaya Mojokerto
Authors: Afif Muthoharun
Published: May 2019

Arabic is an important language for any Muslim community, Learning Arabic is placed as a main activity. It's just that to shape the learning atmosphere while providing opportunities for students to master language skills it becomes a challenge. The objectives of this study are: 1) Describe and analyze the use of interactive learning media assisted by online video can improve critical thinking skills. 2) Describe and analyze the differences in critical thinking skills of students who use interactive learning media assisted by online videos with those who do not use interactive learning media assisted by online videos. 3) Describe and analyze the influence of using online video assisted interactive learning media on critical thinking skills. The research method used was a quasi experiment on two different classes, namely the third semester of STIT Raden Wijaya Mojokerto. One class was treated using interactive learning media and one was given treatment using conventional methods in learning Arabic. The results of the study concluded that: 1) The use of online instructional media assisted by online videos can improve students 'critical thinking skills in the third semester Arabic language courses at STIT Raden Wijaya Mojokerto, 2) There are differences in students' critical thinking skills using online learning media assisted by online video with those who do not use interactive learning media assisted with online videos on the third semester Arabic language courses at STIT Raden Wijaya Mojokerto, 3) The use of online instructional media assisted by online videos has a significant effect on students' critical thinking skills in Arabic semester III at STIT Raden Wijaya Mojokerto
Model Adopsi Daptasi Kurikulum 2013 dan Cambridge University bagi Madrasah
Authors: Isno Isno
Published: May 2019

Cambridge International Examination is a unit at Cambridge University that provides an international curriculum to be adopted in all countries. In accordance with Minister of National Education Regulation (Permendiknas) No. 22/2006, and No.23 / 2006, that schools are given the freedom to develop their education curriculum. The objectives of this study are: 1) Describe the implementation of the 2013 curriculum model and Cambridge University. 2) Describe how to adopt and adapt the 2013 curriculum and Cambridge University. 3) Describe supporting and inhibiting factors Implementation of the 2013 curriculum adaptive adoption model and Cambridge University. This study uses a qualitative approach with a phenomenological study design. Regarding the presence of researchers in qualitative research, researchers acted as the main instrument. To prove that the data in this study can be accounted for, then the technique used is triangulation, which is checking the validity of data by comparing data obtained from one source with the same data from other sources in different times and places. The results of this study concluded: 1) the 2013 curriculum adaptive adoption model and Cambridge University did not leave the Core curriculum and the main points of learning material used from the Ministry of Education and Culture (Kemendikbud) and the Ministry of Religion (Kemenag). 2) Adaptation carried out is the adjustment of certain elements that already exist in the National Education Standards by referring to the Education standards at Cambridge University, or SI / SKL following Islamic education institutions that use SI / SKL from OECD member countries. Adoption of the curriculum is to improve certain elements with other curricula that have certain special qualities or Adoption used is done after going through a mapping process between SI / SKL and SI / SKL by improving KKM and teacher quality. 3) Factors supporting adaptive adoption of 2013 curricula and Cambridge University: 1) extra principal's physical and mental performance, 2) vertical and horizontal coordination of school principals, and 3) innovative thinking of school principals 4) school committees in this case fully support school policy 5) the attitude of the people who have received socialization or at least know that they are very trusting and supportive. 6) the enthusiasm and dedication of teachers who are constantly upgrading themselves and further studies. 7) Learning facilities that meet the requirements 8) availability of funds. The inhibiting factors are: 1) Too idealistic principals so that the ranks are less able to catch up, 2) the headmaster is too careful to make adaptive adoption of the 2013 curriculum and Cambridge University not yet fully implemented, 3) school committees still lack understanding of the 2013 curriculum adaptive system Cambridge University, 4) people who did not know about this implementation, they ridiculed and sanctioned specifically with HR readiness. 5) the distribution of increasing teacher understanding is not balanced