bluuebunny/crossref_metadata_2025 huggingface dataset:
Carboniferous to Triassic polyphase tectonic transition in the western North China craton: A retroarc basin response to termination of the middle segment of the Paleo-Asian Ocean
Authors: Sun Jiaopeng , Dong Yunpeng , Zhao Junfeng , Chen Qiang
Published: March 2024

Knowledge of the closure of the archipelago-type southern Paleo-Asian Ocean has been limited by uncertainty regarding whether the Alxa tectonic belt was isolated from the North China craton by an ocean around the Helanshan tectonic belt. Newly released seismic reflection profiles across the Alxa-Ordos border showed that the Alxa tectonic belt and Ordos Basin were located in a paleogeographically linked basin throughout the Paleozoic, indicating that the Tianshan and Solonker sutures were contiguous. The ca. 320–285 Ma successions in the Helanshan tectonic belt and surroundings, fed by a northeasterly Inner Mongolia continental arc source, display a retrogradational stacking pattern along with diabase sill emplacement. This inferred retroarc extensional setting was coeval with asthenospheric upwelling and thinning of the continental arc driven by retreating subduction of the Paleo-Asian Ocean. The subsequent ca. 280–260 Ma sedimentary hiatus coincided with magmatic flare-up, crustal thickening, and retroarc foreland formation in the Inner Mongolia continental arc, indicating a geodynamic transition from retroarc extension to compression in the mid-Permian. Then craton-scale drainage reorganization occurred during the Early Triassic (ca. 250–230 Ma), manifested by the discharge of the Middle Triassic fluvial system southeastward to the central Ordos Basin; this was steered by southeastward expansion of the Alxa tectonic belt during the final termination of the Paleo-Asian Ocean. Postcollision lithospheric adjustment since ca. 230 Ma resulted in vigorous alkaline magmatism and supracrustal stretching in the Inner Mongolia continental arc as well as mafic magmatism and rifting in the study area. Hence, Carboniferous to Triassic polyphase tectonic transitions in the western North China craton were retroarc basin expressions related to complicated subduction-closure processes in the southern Paleo-Asian Ocean.
On Universal Sampling Recovery in the Uniform Norm
Authors: Temlyakov V. N.
Published: March 2024

It is known that results on universal sampling discretization of the square norm are useful in sparse sampling recovery with error measured in the square norm. In this paper we demonstrate how known results on universal sampling discretization of the uniform norm and recent results on universal sampling representation allow us to provide good universal methods of sampling recovery for anisotropic Sobolev and Nikol’skii classes of periodic functions of several variables. The sharpest results are obtained in the case of functions of two variables, where the Fibonacci point sets are used for recovery.
Case of tizanidine withdrawal showing hallucination, decorticate posture and tremor, with hypersympathetic vital signs
Authors: Tanimura Jun , Hashimoto Takao
Published: March 2024

Tizanidine, an α2-adrenergic receptor agonist commonly prescribed as a muscle relaxant, has been associated with limited cases of acute intoxication or withdrawal. Here, we present a case of tizanidine withdrawal in a woman in her 40s who presented with an unusual combination of systemic and neurological symptoms. These included hallucinations, decorticate posture, limb and eyelid tremors, along with hypertension, tachycardia and tachypnoea. The diagnosis of tizanidine withdrawal was established by a comprehensive assessment of the patient’s medical history and the systematic exclusion of other potential diseases. Our approach to managing the withdrawal symptoms was to initiate symptomatic treatment with a combination of a beta-blocker and a calcium channel blocker. Remarkably, this intervention successfully resolved both vital signs and neurological manifestations by the following day. In conclusion, tizanidine withdrawal is associated with a distinct and diagnostically significant neurological syndrome characterised by hallucinations, decorticate posture, tremors and hypersympathetic vital signs.
Passenger lymphocyte syndrome following minor ABO-mismatched liver transplantation
Authors: Mathavan Akash , Krekora Urszula , Kleehammer Andrew Chase , Mathavan Akshay
Published: March 2024

Passenger lymphocyte syndrome is an immunologic disorder observed in solid organ and haematopoietic stem cell transplantation in which B lymphocytes within a donor graft are transferred to the recipient and subsequently produce circulating antibodies against host red blood cell antigens. The syndrome is most likely to occur in minor ABO blood group mismatched or Rh incompatible transplantation. Although generally mild and self-limited, the resulting haemolytic burden has the potential to increase the risk of infection, graft failure and death. The phenomenon is observed in the transplantation of any solid organ with lymphoid tissue, including the liver. We present a structured case report of passenger lymphocyte syndrome following minor ABO-mismatched liver transplantation, which was initially complicated by blood loss anaemia early in the postoperative period. By reviewing the limited literature of this disorder following liver transplantation, we emphasise common clinical findings and treatment strategies as well as introduce chimerism analysis to confirm resolution.
Phaeochromocytoma and paraganglioma
Authors: Tarling Julie Ann , Kumar Rajeev , Ward Louise J , Boot Christopher , Wassif WS
Published: March 2024

Phaeochromocytomas and paragangliomas are rare catecholamine-producing neuroendocrine tumours which can potentially cause catastrophic crises with high morbidity and mortality. This best practice article considers the causes and presentation of such tumours, screening and diagnostic tests, management of these patients and consideration of family members at risk.
Comparing the frequency of variants of uncertain significance (VUS) between ancestry groups in a paediatric epilepsy cohort
Authors: Martin Bree E , Sands Tristan , Bier Louise , Bergner Amanda , Boehme Amelia K , Lippa Natalie
Published: March 2024

Background

Studies indicate that variants of uncertain significance are more common in non-European populations due to lack of a diversity in population databases. This difference has not been explored in epilepsy, which is increasingly found to be genetic in paediatric populations, and has precision medicine applications. This study examines the differences in the frequency of uncertain next-generation sequencing (NGS) results among a paediatric epilepsy cohort between ancestral groups historically under-represented in biomedical research (UBR) and represented in biomedical research (RBR).

Methods

A retrospective chart review of patients with epilepsy seen at Columbia University Irving Medical Center (CUIMC). One hundred seventy-eight cases met the following criteria: (1) visited any provider within the Pediatric Neurology Clinic at CUIMC, (2) had an ICD code indicating a diagnosis of epilepsy, (3) underwent NGS testing after March 2015 and (4) had self-reported ancestry that fit into a single dichotomous category of either historically represented or under-represented in biomedical research.

Results

UBR cases had significantly higher rates of uncertain results when compared with RBR cases (79.2% UBR, 20.8% RBR; p value=0.002). This finding remained true after controlling for potential confounding factors, including sex, intellectual disability or developmental delay, epilepsy type, age of onset, number of genes tested and year of testing.

Conclusion

Our results add to the literature that individuals who are of ancestries historically under-represented in genetics research are more likely to receive uncertain genetic results than those of represented majority ancestral groups and establishes this finding in an epilepsy cohort.
Clinical uncertainty in large vessel occlusion ischemic stroke: does automated perfusion imaging make a difference? An intra-rater and inter-rater agreement study
Authors: Diestro Jose Danilo Bengzon , Fahed Robert , Omar Abdelsimar Tan , Hawkes Christine , Hendriks Eef J , Enriquez Clare , Eesa Muneer , Stotts Grant , Lee Hubert , Nagendra Shashank , Poppe Alexandre , Ducroux Célina , Lim Timothy , Narvacan Karl , Rizzuto Michael , Alfalahi Afra , Nishi Hidehisa , Sarma Pragyan , Itsekson Hayosh Ze'ev , Ignacio Katrina , Boisseau William , Pimenta Ribeiro Pontes Almeida Eduardo , Benomar Anass , Almekhlafi Mohammed A , Milot Genvieve , Deshmukh Aviraj , Kishore Kislay , Tampieri Donatella , Wang Jeffrey , Srivastava Abhilekh , Roy Daniel , Carpani Federico , Kashani Nima , Candale-Radu Claudia , Singh Nishita , Bres Bullrich Maria , Sarmiento Robert , Muir Ryan T , Parra-Fariñas Carmen , Reiter Stephanie , Deschaintre Yan , Singh Ravinder-Jeet , Bodani Vivek , Katsanos Aristeidis , Agid Ronit , Zafar Atif , Pereira Vitor M , Spears Julian , Marotta Thomas R , Djiadeu Pascal , Sharma Sunjay , Farrokhyar Forough
Published: March 2024

Background

Limited research exists regarding the impact of neuroimaging on endovascular thrombectomy (EVT) decisions for late-window cases of large vessel occlusion (LVO) stroke.

Objective

T0 assess whether perfusion CT imaging: (1) alters the proportion of recommendations for EVT, and (2) enhances the reliability of EVT decision-making compared with non-contrast CT and CT angiography.

Methods

We conducted a survey using 30 patients drawn from an institutional database of 3144 acute stroke cases. These were presented to 29 Canadian physicians with and without perfusion imaging. We used non-overlapping 95% confidence intervals and difference in agreement classification as criteria to suggest a difference between the Gwet AC1 statistics (κG).

Results

The percentage of EVT recommendations differed by 1.1% with or without perfusion imaging. Individual decisions changed in 21.4% of cases (11.3% against EVT and 10.1% in favor). Inter-rater agreement (κG) among the 29 raters was similar between non-perfusion and perfusion CT neuroimaging (κG=0.487; 95% CI 0.327 to 0.647 and κG=0.552; 95% CI 0.430 to 0.675). The 95% CIs overlapped with moderate agreement in both. Intra-rater agreement exhibited overlapping 95% CIs for all 28 raters. κGwas either substantial or excellent (0.81–1) for 71.4% (20/28) of raters in both groups.

Conclusions

Despite the minimal difference in overall EVT recommendations with either neuroimaging protocol one in five decisions changed with perfusion imaging. Regarding agreement we found that the use of automated CT perfusion images does not significantly impact the reliability of EVT decisions for patients with late-window LVO.
Bridging comic art and research: lessons from an interdisciplinary collaboration project in a palliative care context
Authors: Haan Maaike , Olthuis Gert , Boenink Marianne , van Gurp Jelle
Published: March 2024

The Dutch graphic novel
Naasten
, about palliative family caregiving, is the product of an interdisciplinary collaboration between researchers and two comic artists. This paper aims to present lessons, reflections and practical recommendations for other researchers interested in adopting (comic) arts-based research methods, in which artistic methods are used as novel ways for generating, analysing, interpreting or representing research data.

Our project started with the goal of translation: we aimed at representing research findings into a more accessible, visual and textual form to stimulate discussion and reflection outside academia on moral challenges in family care. This was inspired by comics’ hypothesised potential to show complex and embodied experiences, thus enabling more understanding in readers and offering powerful science communication tools. Although this goal of translation was realised in our project, we learnt along the way that the project could have benefited from a more explicit focus on interdisciplinarity from the start and by monitoring the interdisciplinary learning opportunities throughout the project. The following issues are important for any art-research collaboration: (1) an interest in and acknowledgement of each other’s (potentially diverging) aims and roles: all parties should—from the start—commit themselves to interdisciplinary collaboration and to exploring the added value of using each other’s methods, thereby finding a common methodological ground and language; (2) a continuous discussion of the sometimes contrasting approaches between artists and researchers: differences in using theory and story may result in different criteria for creating good art. When balancing scientific and aesthetic aims, the trustworthiness of the art work should remain an important criterion; (3) an awareness of the potential of interdisciplinary collaboration to offering new perspectives on one’s scientific data collection and analysis, for example, providing other conceptualisations or indicating blind spots, provided that artists are involved in the early phases of research.
A new perspective for palladium(II)-catalyzed alcohol oxidation in aerobic means
Authors: Maronde Daiane N. , Venancio Aldino N. , Bolsoni Camilla S. , Menini Luciano , Santos Mario F.C. , Parreira Luciana A.
Published: March 2024

The development of alternative and environmentally safe routes for the oxidation of primary and secondary alcohols has attracted the attention of several researchers due to the importance of these oxidized products in industries. Thereby, the oxidation of β-citronellol, geraniol, nerol, borneol, isoborneol, cinnamic alcohol, and benzyl alcohol is described herein. These reactions occurred in an aerobic environment, with or without system pressurization. Acetonitrile was the solvent used. The process was catalyzed by the bimetallic complex formed with palladium(II) acetate and copper(II) acetate, using p-benzoquinone as a cocatalyst in some reaction conditions. The applied system obtained 62.5 points on the eco-scale, with yields above 61%. Alcohol oxidation products are of great importance in industrial applications. Thus, this work presents a cleaner, more sustainable alternative to alcohol oxidations.
Ground-state energy of H−: a critical test of triple basis sets
Authors: Petrimoulx E.M.R. , Bondy A.T. , Ene E.A. , Sati L.A. , Drake G.W.F.
Published: March 2024

We report an improved variational upper bound for the ground state energy of H− using Hylleraas-like wave functions in the form of a triple basis set having three distinct distance scales. The extended precision DQFUN of Bailey, allowing for 70 decimal digit arithmetic, is implemented to retain sufficient precision. Our result exceeds the previous record [A. M. Frolov, Euro. J. Phys. D 69, 132 (2015)], indicating that the Hylleraas triple basis set exhibits comparable convergence to the widely used pseudorandom all-exponential basis sets, but the numerical stability against roundoff error is much better. It is argued that the three distance scales have a clear physical interpretation. The new variational bound for infinite nuclear mass is –0.527 751 016 544 377 196 590 814 478 a.u. New variational bounds are also presented for the finite mass cases of the hydrogen, deuterium, and tritium negative ions H−, D−, and T−.
Instability and quantization in quantum hydrodynamics
Authors: Aharonov Yakir , Shushi Tomer
Published: March 2024

We show how the quantum hydrodynamical formulation of quantum mechanics converts the nonlocality in the standard wave-like description of quantum systems by an instability of the quantum system, which opens the door to a new way for studying quantum systems based on known methodologies for studying the stability of fluids. As a second result, we show how the Madelung equations describe quantized energies without any external quantization conditions.
Four Limit Cycles of Three-Dimensional Discontinuous Piecewise Differential Systems Having a Sphere as Switching Manifold
Authors: Baymout Louiza , Benterki Rebiha
Published: March 2024

Because of their applications, the study of piecewise-linear differential systems has become increasingly important in recent years. This type of system already exists to model many different natural phenomena in physics, biology, economics, etc. As is well known, the study of the qualitative theory of piecewise differential systems focuses mainly on limit cycles. Most papers studying the problem of existence and the maximum number of limit cycles of piecewise differential systems have precisely considered planar systems. However, few papers have examined this problem in [Formula: see text]. In this paper, our main goal is to examine a class of discontinuous piecewise differential systems in [Formula: see text], where we consider the unit sphere as the separation surface that divides the entire space into two regions, each one has a linear vector field analogous to planar center. In general, it is hard to determine an exact upper bound for the number of limit cycles that a class of differential systems can exhibit. We prove that this class of differential systems can have at most four limit cycles. We show that there are examples of such differential systems with exactly 1, 2, 3 and 4 limit cycles.
Iterated mapping cones on the Koszul complex and their application to complete intersection rings
Authors: Nguyen Van C. , Veliche Oana
Published: March 2024

Let [Formula: see text] be a complete intersection local ring, [Formula: see text] be the Koszul complex on a minimal set of generators of [Formula: see text], and [Formula: see text] be its homology algebra. We establish exact sequences involving direct sums of the components of [Formula: see text] and express the images of the maps of these sequences as homologies of iterated mapping cones built on [Formula: see text]. As an application of this iterated mapping cone construction, we recover a minimal free resolution of the residue field [Formula: see text] over [Formula: see text], independent from the well-known resolution constructed by Tate by adjoining variables and killing cycles. Through our construction, the differential maps can be expressed explicitly as blocks of matrices, arranged in some combinatorial patterns.
A New Method of Distance Measure Between Intuitionistic Fuzzy Sets and its Application in Admission Procedure
Authors: Ejegwa Paul Augustine , Anum Manasseh Terna , Isife Kenneth Ifeanyi
Published: March 2024

Sundry complex real-world problems involving decision-making have been resolved using the idea of distance measures between intuitionistic fuzzy sets (IFSs). Several distance measuring techniques between IFSs have been developed, but it is only the work of Xie et al. that considered the tendency coefficients of the intuitionistic fuzzy parameters (IFPs), namely, membership grade, nonmembership grade and hesitation grade. Albeit, Xie et al.’s technique uses assumed tendency coefficients for IFPs, which is defective for a reliable result. Sequel to this setback, we develop a new distance measure between IFSs which includes tendency coefficients of the IFPs, where the tendency coefficients are computed from the intuitionistic fuzzy values to enhance reliable results. In addition, the new distance measure between IFSs is applied to discuss students’ admission process to ascertain the most eligible candidate based on academic performance in an entry examination. The application is carried out using two techniques, namely, the recognition principle and the multiple criteria decision-making approach, respectively. Finally, the superiority of the newly developed distance measure between IFSs is shown comparatively with respect to the existing approaches between IFSs. This new distance measure can be applied to clustering analysis, multiple attributes decision-making (MADM), a technique for order preference by similarity to ideal solution (TOPSIS), etc. in future research.
Optimism in Property Markets
Authors: Cosic Hana , Muradoglu Yaz Gulnur
Published: March 2024

House valuation involves forecasting household demand for a neighborhood, whereas commercial property valuation involves forecasting area economic activity. Yet, we show optimistic expectations for both. We investigate further possible disparities due to different cultures of home ownership, short, medium, and long-term investment horizons, and bullish or bearish trends. We use an experimental framework to demonstrate expectations are optimistic under all conditions. Buyers use trends to surmise future prices in bull markets, expect price increases in oscillating markets, and price reversals in bear markets, failing to anticipate price busts. Policy implications are important in preventing property boom-induced financial crises.
A century of urban landslides: the legacy and consequences of altering riverbank landscapes
Authors: Bennett Isabella B. , Bierman P. R.
Published: March 2024

Urban landslides are a deadly and costly hazard. Human actions, such as altering the grade, composition and vegetation-cover of hillslopes, can increase the threat of mass movements. Here, we use an interdisciplinary approach to examine the spatial distribution, timing and cause of landslides affecting a state highway and adjacent buildings along the top of a steep, urban riverbank in the mid-latitude, humid-temperate state of Vermont. Using over 100 years of mapping, photographs and written records, we demonstrate that most mass movements in our field area occurred on slopes oversteepened by the addition of uncompacted artificial fill, added without engineering considerations. Emplaced atop glacial and post-glacial sediment with low hydraulic conductivity, the fill, having little to no cohesion, expanded buildable areas, but the new infrastructure sat on unstable ground. Over the following decades, repeated failures (
n
 = 20), mostly shallow translational landslides in fill material along with several deeper-seated rotational slides, sent buildings, trees and segments of road into the river below. Solutions include incentivizing the removal of structures built on fill and limiting further filling activities through changes in zoning regulations and more effective enforcement of existing municipal codes. The approach we use provides a framework for similar geographical settings and can inform urban planning and risk assessment.

Supplementary material
: Supplementary photographs and imagery, and a list of references for all historical photographs and maps used in this study, are available at
https://doi.org/10.6084/m9.figshare.c.7103608

Thematic collection:
This article is part of the Engineering Geology and Hydrogeology of the Anthropocene collection available at:
https://www.lyellcollection.org/topic/collections/engineering-geology-and-hydrogeology-of-the-anthropocene
Middle Eastern carbonate reservoirs – the critical impact of discrete zones of elevated permeability on reservoir performance
Authors: Cross Nigel E. , Burchette Trevor P.
Published: March 2024

Middle Eastern carbonate petroleum reservoirs exhibit a range of heterogeneities which consist of variable combinations of primary stratigraphic and secondary diagenetic and structural characteristics. These produce diverse permeability architectures which can exert a profound influence on reservoir performance during secondary recovery. Of particular importance are laterally persistent discrete zones of elevated permeability (DZEP) that typically make up a volumetrically minor proportion of the reservoir yet show disproportionately high fluid inflow or outflow. The stratigraphic, diagenetic and structural origins of elevated permeability in Middle Eastern carbonate reservoirs are considered here and the consequences of such features for reservoir performance are discussed. The term DZEP denotes geological sources of elevated permeability at least an order of magnitude greater than background reservoir properties. Stratigraphically organized DZEP comprise coarse-grained layers, event beds or parasequence tops or bases in neritic or platform interior settings. Other origins include bioturbated layers, grainy clinothems and bed-scale, grain-size variations in shoal deposits. Diagenetic DZEP are typically dissolution horizons with mouldic and touching-vug pore networks or dolomitized intervals which often overprint stratigraphic DZEP. Structural DZEP include individual faults, fracture corridors and fracture concentrations related to mechanical stratigraphy. During production through natural pressure depletion, DZEP may dominate well productivity. Under secondary recovery, the same intervals may dominate inter-well fluid flow, causing flood conformance issues, cross-zone fluid movement, bypassed pay and earlier-than-expected water or gas breakthrough to production wells. Optimization of production and ultimate recovery rely on collecting the correct kinds of data at a sufficiently early stage in the reservoir characterization process to permit their inclusion in static and dynamic reservoir models.
The Science of Detecting LLM-Generated Text
Authors: Tang Ruixiang , Chuang Yu-Neng , Hu Xia
Published: March 2024

While many detection methods have been proposed, understanding the challenges is far more daunting.
Pushed by Sound: Effects of Sound and Movement Direction on Body Perception, Experience Quality, and Exercise Support
Authors: Singh Aneesha , Hrobat Marusa , Gui Suxin , Bianchi-Berthouze Nadia , Ley-Flores Judith , Bevilacqua Frederic , Duran Joaquin R. Diaz , Segura Elena MÁrquez , Tajadura-JimÉnez Ana
Published: March 2024

Wearables integrating movement sonification can support body-perception changes and related physical activity; yet, we lack design principles for such sonifications. Through two mixed-methods studies, we investigate sound pitch and movement direction interaction effects on self-perception during squat exercises. We measured effects on body perception, affective quality of the experience, and actual and perceived movement, and compared them with two control conditions: no-sound and vibrotactile feedback. Results show that regardless of movement direction, ascending pitch enhances several body feelings and overall experience quality, while descending pitch increases movement acceleration. These effects were moderated by exercise physical demand. Sound and vibrotactile feedback enhanced flexibility and strength feelings, respectively, and contributed to exercise completion in different ways. Sound was perceived as an internal-to-body force while vibrotactile feedback was perceived as an external-to-body force. Feedback effects were stronger in people with lower fitness levels. We discuss results in terms of malleability of body perceptions and highlight opportunities to support demanding physical activity through wearable devices.
The Game Industry’s Cataclysmic Layoffs: Where Do We Go from Here?
Authors: Farough Amanda , Futter Michael
Published: March 2024

The games industry has been seeing unparalleled mass layoffs since 2022. Cheap debt, the COVID-19 bubble, investor imprudence, and executive extravagance have produced an unsustainable boom and investment spree that has flowed into today’s disastrous bust. For workers in the games industry, collective organization is a difficult but necessary response to ensure a healthier and more resilient future for all.
Determination Methods and Influencing Factors of Grain Mechanical Properties
Authors: Gao Peng , Tian Shuangqi , Xue Xing’ao , Lu Jing
Published: March 2024

Grain is extremely vulnerable to external loads during production and processing, resulting in the deterioration of grain quality. Deteriorated grain not only affects the economic value of grain but also affects the safety of storage. This has a very important relationship with the biomechanical properties of grains. It is of great significance to explore the mechanical properties of grain under different conditions and analyze the relationship between its physical and chemical properties and mechanical properties for improving its processing and eating quality. In this paper, the research methods of the mechanical properties of grains are reviewed. Various factors influencing the mechanical properties of cereals were analyzed. The relationship between the internal organizational structure of grain and its mechanical properties was discussed. This paper puts forward the shortcomings in the current research on the mechanical properties of grains and puts forward the prospect and analysis of its importance in future development in order to provide a reference for reducing crushing in the grain processing process.
A Comprehensive Narrative Review on the Hazards of Bee Honey Adulteration and Contamination
Authors: Morariu Ionela-Daniela , Avasilcai Liliana , Vieriu Madalina , Lupu Vasile Valeriu , Ioniuc Ileana , Morariu Branco-Adrian , Lupu Ancuța , Morariu Paula-Cristina , Pop Oana-Lelia , Burduloi Vladut Mirel , Starcea Iuliana Magdalena , Trandafir Laura
Published: March 2024

Honey bees are renowned for producing a remarkable substance known as bee honey, which stands as a functional food celebrated for its numerous health benefits. This natural wonder possesses a spectrum of advantageous properties, including anti-inflammatory, antioxidant, analgesic, antibacterial, and wound-healing qualities. However, in our modern era of heightened utilization of bee products, a new and pressing global health concern has emerged—the contamination of honey with pesticides, antibiotics, microorganisms, and heavy metals. The consumption of beekeeping products containing pesticide residues has been linked to a range of health issues, including genetic malformations, cellular degradation, allergic reactions, and even potential carcinogenic effects. Troublingly, documented cases exist of botulism in newborns resulting from the ingestion of contaminated honey. Additionally, the use of antibiotics in beekeeping practices has been associated with the concerning emergence of antibiotic resistance. This comprehensive review sheds light on the substantial consequences of honey contamination for human health. It underscores the urgent need for the establishment of a rigorous monitoring system, the validation of minimum acceptable pollutant levels, and, at the very least, the regulation of maximum residue limits for bee products, with a particular emphasis on bee honey.
Development and Implementation of an FPGA-Embedded Multimedia Remote Monitoring System for Information Technology Server Room Management
Authors: Zhu Yongqin , Hou Kaiwen
Published: March 2024

Conventional data acquisition systems face challenges in achieving high acquisition speeds and rapid storage of large data volumes using microcontrollers. In contrast, field-programmable gate arrays (FPGAs) offer numerous advantages, including high clock frequencies, minimal internal delays, fast operational speeds, abundant internal RAM resources, and simplified control of complex peripheral circuits. This study presents the design of an FPGA-based multimedia remote monitoring system for information technology server rooms. The proposed system utilizes an FPGA as the primary controller and incorporates environmental sensors, electrical energy sensors, carbon monoxide sensors, smoke sensors, and A/D converter modules to monitor multiple locations within the server room. Simultaneously, the FPGA transmits the collected data from each monitoring point via a serial port to an LCD serial screen for display. An alarm is triggered if any environmental anomalies are detected, indicating abnormal statuses. Additionally, the system employs the fast Fourier transform algorithm and butterfly operations to derive voltage and current AC quantities, while utilizing relative temperature differences to identify equipment faults within the server room. The system is evaluated in terms of functionality, user-friendliness, and reliability. Experimental results demonstrate that all performance measures align with expectations, fulfilling the initial design objectives and highlighting the potential applicability and relevance of FPGA technology in the monitoring field. In addition, a comparison between FPGA and traditional microcontroller systems is performed, showcasing the superior processing speed and performance of the FPGA-based system. This comparative analysis further validates the advantages of using FPGA technology in high-speed data acquisition and monitoring applications.
Diabetes Risk Reduction Diet and Colorectal Cancer Risk
Authors: Natale Arianna , Turati Federica , Taborelli Martina , Giacosa Attilio , Augustin Livia S.A. , Crispo Anna , Negri Eva , Rossi Marta , La Vecchia Carlo
Published: March 2024

Background:

Diabetes has been associated with colorectal cancer. We evaluated whether adherence to a diabetes risk reduction diet (DRRD) can favorably influence the risk of colorectal cancer.

Methods:

Data came from a multicentric Italian case-control study including 1,953 histologically confirmed colorectal cancer cases and 4,154 hospital controls admitted for acute nonneoplastic diseases. Diet was assessed through a validated and reproducible food frequency questionnaire. The DRRD score was computed assigning higher values for higher consumption of cereal fiber, fruit, coffee, nuts and a higher polyunsaturated/saturated fats ratio and for lower glycemic index and lower consumption of red/processed meat and sweetened beverages and fruit juices. The ORs and the corresponding 95% confidence intervals (CI) of colorectal cancer according to the DRRD score were obtained using logistic regression models adjusting for total energy intake and other major confounders.

Results:

The DRRD was inversely related to colorectal cancer risk. The ORs of colorectal cancer were 0.77 (95% CI, 0.67–0.89) for the third versus first score tertile (Ptrend < 0.001) and 0.92 (95% CI, 0.87–0.96) for a 3-point increment in the score. Inverse associations were observed for colon and rectal cancers and were consistent in strata of sex, age, and other major covariates.

Conclusions:

A higher adherence to a DRRD was inversely associated with colorectal cancer risk.

Impact:

Given the high incidence and mortality rates of colorectal cancer, adherence to a DRRD can have relevant prevention and public health implications.
Table S6 from Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma
Authors: Flint Alyssa C. , Mitchell Dana K. , Angus Steven P. , Smith Abbi E. , Bessler Waylan , Jiang Li , Mang Henry , Li Xiaohong , Lu Qingbo , Rodriguez Brooke , Sandusky George E. , Masters Andi R. , Zhang Chi , Dang Pengtao , Koenig Jenna , Johnson Gary L. , Shen Weihua , Liu Jiangang , Aggarwal Amit , Donoho Gregory P. , Willard Melinda D. , Bhagwat Shripad V. , Clapp D. Wade , Rhodes Steven D.
Published: March 2024

Dosing and schedule of abemaciclib and LY3214996
Table S5 from Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma
Authors: Flint Alyssa C. , Mitchell Dana K. , Angus Steven P. , Smith Abbi E. , Bessler Waylan , Jiang Li , Mang Henry , Li Xiaohong , Lu Qingbo , Rodriguez Brooke , Sandusky George E. , Masters Andi R. , Zhang Chi , Dang Pengtao , Koenig Jenna , Johnson Gary L. , Shen Weihua , Liu Jiangang , Aggarwal Amit , Donoho Gregory P. , Willard Melinda D. , Bhagwat Shripad V. , Clapp D. Wade , Rhodes Steven D.
Published: March 2024

Statistics from DESeq2
Figure S8 from Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma
Authors: Flint Alyssa C. , Mitchell Dana K. , Angus Steven P. , Smith Abbi E. , Bessler Waylan , Jiang Li , Mang Henry , Li Xiaohong , Lu Qingbo , Rodriguez Brooke , Sandusky George E. , Masters Andi R. , Zhang Chi , Dang Pengtao , Koenig Jenna , Johnson Gary L. , Shen Weihua , Liu Jiangang , Aggarwal Amit , Donoho Gregory P. , Willard Melinda D. , Bhagwat Shripad V. , Clapp D. Wade , Rhodes Steven D.
Published: March 2024

Pharmacokinetic Evaluation of abemaciclib and LY3214996
Figure S13 from Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma
Authors: Flint Alyssa C. , Mitchell Dana K. , Angus Steven P. , Smith Abbi E. , Bessler Waylan , Jiang Li , Mang Henry , Li Xiaohong , Lu Qingbo , Rodriguez Brooke , Sandusky George E. , Masters Andi R. , Zhang Chi , Dang Pengtao , Koenig Jenna , Johnson Gary L. , Shen Weihua , Liu Jiangang , Aggarwal Amit , Donoho Gregory P. , Willard Melinda D. , Bhagwat Shripad V. , Clapp D. Wade , Rhodes Steven D.
Published: March 2024

Etv4, Dusp6, Phlda1, and Dusp4 mRNA expression
TABLE 2 from CALGB 80802 (Alliance): Impact of Sorafenib with and without Doxorubicin on Hepatitis C Infection in Patients with Advanced Hepatocellular Carcinoma
Authors: Abou-Alfa Ghassan K. , Geyer Susan M. , Nixon Andrew B. , Innocenti Federico , Shi Qian , Kumthekar Priya , Jacobson Sawyer , El Dika Imane , Yaqubie Amin , Lopez Juan , Huang Binhui , Tang Yi-Wei , Wen Yujia , Schwartz Lawrence H. , El-Khoueiry Anthony B. , Knox Jennifer J. , Rajdev Lakshmi , Bertagnolli Monica M. , Meyerhardt Jeffrey A. , O'Reilly Eileen M. , Venook Alan P.
Published: March 2024

Cox proportional hazards model results for PFS and OS. Each row reflects a model with that variable; models across all patients are stratified on treatment arm. Baseline HCV only includes those with pretreatment HCV titer data available (n = 43), and first sample HCV includes baseline HCV titer data for those with it available and cycle 2 data for those missing baseline (n = 53)
TABLE 1 from CALGB 80802 (Alliance): Impact of Sorafenib with and without Doxorubicin on Hepatitis C Infection in Patients with Advanced Hepatocellular Carcinoma
Authors: Abou-Alfa Ghassan K. , Geyer Susan M. , Nixon Andrew B. , Innocenti Federico , Shi Qian , Kumthekar Priya , Jacobson Sawyer , El Dika Imane , Yaqubie Amin , Lopez Juan , Huang Binhui , Tang Yi-Wei , Wen Yujia , Schwartz Lawrence H. , El-Khoueiry Anthony B. , Knox Jennifer J. , Rajdev Lakshmi , Bertagnolli Monica M. , Meyerhardt Jeffrey A. , O'Reilly Eileen M. , Venook Alan P.
Published: March 2024

Patient characteristics by HCV titer status on first available sample, for patients with available sample
Table S2 from Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Authors: Carroll Christopher , Manaprasertsak Auraya , Boffelli Castro Arthur , van den Bos Hilda , Spierings Diana C.J. , Wardenaar René , Bukkuri Anuraag , Engström Niklas , Baratchart Etienne , Yang Minjun , Biloglav Andrea , Cornwallis Charlie K. , Johansson Bertil , Hagerling Catharina , Arsenian-Henriksson Marie , Paulsson Kajsa , Amend Sarah R. , Mohlin Sofie , Foijer Floris , McIntyre Alan , Pienta Kenneth J. , Hammarlund Emma U.
Published: March 2024

Table S2: Sequences of CRISPR gRNA to produce EPAS1 KO.
Figure S2 from Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Authors: Carroll Christopher , Manaprasertsak Auraya , Boffelli Castro Arthur , van den Bos Hilda , Spierings Diana C.J. , Wardenaar René , Bukkuri Anuraag , Engström Niklas , Baratchart Etienne , Yang Minjun , Biloglav Andrea , Cornwallis Charlie K. , Johansson Bertil , Hagerling Catharina , Arsenian-Henriksson Marie , Paulsson Kajsa , Amend Sarah R. , Mohlin Sofie , Foijer Floris , McIntyre Alan , Pienta Kenneth J. , Hammarlund Emma U.
Published: March 2024

Figure S2: Brightfield images of cell lines after treatment with LD50 cisplatin.
Figure S13 from Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Authors: Carroll Christopher , Manaprasertsak Auraya , Boffelli Castro Arthur , van den Bos Hilda , Spierings Diana C.J. , Wardenaar René , Bukkuri Anuraag , Engström Niklas , Baratchart Etienne , Yang Minjun , Biloglav Andrea , Cornwallis Charlie K. , Johansson Bertil , Hagerling Catharina , Arsenian-Henriksson Marie , Paulsson Kajsa , Amend Sarah R. , Mohlin Sofie , Foijer Floris , McIntyre Alan , Pienta Kenneth J. , Hammarlund Emma U.
Published: March 2024

Figure S13: Effects of T2445 treatment on cellular proliferation at 10nM.
Figure S11 from Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Authors: Carroll Christopher , Manaprasertsak Auraya , Boffelli Castro Arthur , van den Bos Hilda , Spierings Diana C.J. , Wardenaar René , Bukkuri Anuraag , Engström Niklas , Baratchart Etienne , Yang Minjun , Biloglav Andrea , Cornwallis Charlie K. , Johansson Bertil , Hagerling Catharina , Arsenian-Henriksson Marie , Paulsson Kajsa , Amend Sarah R. , Mohlin Sofie , Foijer Floris , McIntyre Alan , Pienta Kenneth J. , Hammarlund Emma U.
Published: March 2024

Figure S11: Survival of polyploid cells is reduced by the addition of NOTCH inhibitor during cisplatin treatment.
FIGURE 4 from Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Authors: Carroll Christopher , Manaprasertsak Auraya , Boffelli Castro Arthur , van den Bos Hilda , Spierings Diana C.J. , Wardenaar René , Bukkuri Anuraag , Engström Niklas , Baratchart Etienne , Yang Minjun , Biloglav Andrea , Cornwallis Charlie K. , Johansson Bertil , Hagerling Catharina , Arsenian-Henriksson Marie , Paulsson Kajsa , Amend Sarah R. , Mohlin Sofie , Foijer Floris , McIntyre Alan , Pienta Kenneth J. , Hammarlund Emma U.
Published: March 2024

Protein changes validate the role of HIF2α and RB1 for cell survival. A, Protein level changes of HIF2α-interacting proteins, MCM7, HIC7, and NUR77 in HCC1806 and HCT116 cells when untreated (CTL), when surviving at 0 DPT, 5 DPT, and 10 DPT and as progeny; demonstrated by Western blot analysis. Actin was used as a loading control. Molecular weight markers in kDa are shown to the left. B, Representative images of protein level changes of RB1 and its phosphorylated sites (s790, s780, and s807) in HCC1806 and HCT116 cells when untreated (CTL), when surviving at 0 DPT, 5 DPT, 10 DPT and as progeny; as determined by Western blot analysis. C, Protein level changes of HIF2α and its targets SERPINB9, VEGF, and DEC1 in HCC1806 and HCT116 cells when untreated (CTL), as surviving at 0 DPT, 5 DPT, and 10 DPT and as progeny; as determined with Western blot analysis. D, Protein level changes of VHL and PHD1–3 in HCC1806 and HCT116 cells when untreated (CTL), when surviving at 0 DPT, 5 DPT, and 10 DPT, and as progeny; as determined with Western blot analysis. E, Number of HCC1806 and HCT116 cells surviving at 0 DPT and 10 DPT when treated with cisplatin only or cisplatin together with the HIF2α inhibitor Belzutifan. F, Number of LS174T and HCT116 colon cancer cells surviving cisplatin at 0 DPT and 10 DPT as “normal” and with k HIF2α KO from biological replicates (n = 3) and P-value (∗∗, P < 0.01; ∗, P < 0.05; significant relative to vehicle) by ANOVA test as indicated.
Code S1 from Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Authors: Carroll Christopher , Manaprasertsak Auraya , Boffelli Castro Arthur , van den Bos Hilda , Spierings Diana C.J. , Wardenaar René , Bukkuri Anuraag , Engström Niklas , Baratchart Etienne , Yang Minjun , Biloglav Andrea , Cornwallis Charlie K. , Johansson Bertil , Hagerling Catharina , Arsenian-Henriksson Marie , Paulsson Kajsa , Amend Sarah R. , Mohlin Sofie , Foijer Floris , McIntyre Alan , Pienta Kenneth J. , Hammarlund Emma U.
Published: March 2024

Code S1: Code for a Gaussian mixture model with two components.
Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression
Authors: Crump Lyndsey S. , Floyd Jessica L. , Kuo Li-Wei , Post Miriam D. , Bickerdike Mike , O'Neill Kathleen , Sompel Kayla , Jordan Kimberly R. , Corr Bradley R. , Marjon Nicole , Woodruff Elizabeth R. , Richer Jennifer K. , Bitler Benjamin G.
Published: March 2024

High-grade serous carcinoma (HGSC) of the fallopian tube, ovary, and peritoneum is the most common type of ovarian cancer and is predicted to be immunogenic because the presence of tumor-infiltrating lymphocytes conveys a better prognosis. However, the efficacy of immunotherapies has been limited because of the immune-suppressed tumor microenvironment (TME). Tumor metabolism and immune-suppressive metabolites directly affect immune cell function through the depletion of nutrients and activation of immune-suppressive transcriptional programs. Tryptophan (TRP) catabolism is a contributor to HGSC disease progression. Two structurally distinct rate-limiting TRP catabolizing enzymes, indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2), evolved separately to catabolize TRP. IDO1/TDO2 are aberrantly expressed in carcinomas and metabolize TRP into the immune-suppressive metabolite kynurenine (KYN), which can engage the aryl hydrocarbon receptor to drive immunosuppressive transcriptional programs. To date, IDO inhibitors tested in clinical trials have had limited efficacy, but those inhibitors did not target TDO2, and we find that HGSC cell lines and clinical outcomes are more dependent on TDO2 than IDO1. To identify inflammatory HGSC cancers with poor prognosis, we stratified patient ascites samples by IL6 status, which correlates with poor prognosis. Metabolomics revealed that IL6-high patient samples had enriched KYN. TDO2 knockdown significantly inhibited HGSC growth and TRP catabolism. The orally available dual IDO1/TDO2 inhibitor, AT-0174, significantly inhibited tumor progression, reduced tumor-associated macrophages, and reduced expression of immune-suppressive proteins on immune and tumor cells. These studies demonstrate the importance of TDO2 and the therapeutic potential of AT-0174 to overcome an immune-suppressed TME.

Significance:

Developing strategies to improve response to chemotherapy is essential to extending disease-free intervals for patients with HGSC of the fallopian tube, ovary, and peritoneum. In this article, we demonstrate that targeting TRP catabolism, particularly with dual inhibition of TDO2 and IDO1, attenuates the immune-suppressive microenvironment and, when combined with chemotherapy, extends survival compared with chemotherapy alone.
Roles for Implicit Bias Science in Antidiscrimination
Law
Authors: Greenwald Anthony G. , Newkirk Thomas
Published: March 2024

Declining scholarly interest in intentional discrimination may be due to rapid growth of interest in systemic biases and implicit biases. Systemic biases are produced by organizational personnel doing their assigned jobs, but nevertheless causing adverse impacts to members of protected classes as identified in civil rights laws. Implicit biases are culturally formed stereotypes and attitudes that cause selective harms to protected classes while operating mostly outside of conscious awareness. Both are far more pervasive and responsible for much greater adversity than caused by overt, explicit bias, such as hate speech. Scientific developments may eventually influence jurisprudence to reduce effects of systemic and implicit biases, but likely not rapidly. We conclude by describing possibilities for executive leadership in both public and private sectors to ameliorate discrimination faster and more effectively than is presently likely via courts and legislation.
Retooling Career Systems to Fight Workplace Bias: Evidence from U.S.
Corporations
Authors: Kalev Alexandra , Dobbin Frank
Published: March 2024

The civil rights movement spurred U.S. companies and universities to implement antidiscrimination programs. Beginning in the early 1960s, employers adopted anti bias training as their first line of defense against bigotry. Even then, there was substantial evidence that this approach was unlikely to lessen bias. In this essay, we discuss social science research on the effects of antibias training, as well as research on systemic approaches to reducing institutional discrimination based on insights from contact theory. As sociologist Samuel Stouffer and psychologist Gordon Allport, the progenitors of contact theory, might have predicted by the end of World War II, we find that interventions to change career systems to maximize intergroup contact can promote workplace equity.