bluuebunny/crossref_metadata_2025 huggingface dataset:
VITAMIN D DEFICIENCY IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS
Authors: Q MOHAMMED JINAN , MATHKHOR ABDULSATAR J , S KHUDHAIRY AMER
Published: January 2021

Objective: The objective of this study is to investigate the association between Vitamin D level and psoriasis, in particular in our city of the long, hot, and sunny weather, in an attempt to add a clarification to this controversial subject.

Methods: A case–control study included 120 patients with psoriasis and 38 patients with psoriatic arthritis (PsA); 89 (56.3%) patients were male. Psoriasis area and severity index (PASI) was calculated for all patients with psoriasis and disease activity score using 28 joints (DAS28) and erythrocyte sedimentation rate (DAS28) was measured for all patients with PsA. The control group comprised 164 age- and sex-matched participants (91 males and 73 females). Vitamin D serum level was performed for both patients and controls.

Results: Vitamin D levels in both patients and controls were 17.4±7.7 and 28.3±5.6, respectively. The level of Vitamin D was lower in a patient with disease duration equal and more than 10 years than those with a disease duration <10 years. There is no significant difference in Vitamin D levels between the two patient subgroups. Lower Vitamin D levels were associated with high PASI and high DAS28 in psoriasis and PsA, respectively.

Conclusion: Patients with psoriasis and PsA associated with low levels of serum Vitamin D. Vitamin D deficiency was found to be associated with long disease duration in both psoriasis and PsA. Patients with active disease have lower Vitamin D levels.
STUDY OF THE ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF ROOT OF ACORUS CALAMUS IN ALBINO MICE
Authors: KAUSHIK SHIPRA , KAUSHIK SHOBHIT
Published: January 2021

Objective: Anxiety is classified as a form of sub-acute or chronic fear. Root of Acorus calamus has been traditionally used as an anxiolytic. The aim of the study is to assess the anxiolytic activity of ethanolic extract of A. calamus (EEAC) by elevated plus-maze test on Albino mice.

Methods: Albino mice of either sex were taken and divided into five groups, each consisting of 5 mice. One group was used as control, one as standard (diazepam), and three as test groups treated with 100, 200, and 400 mg/kg of EEAC. The drugs, that is, 10 ml/kg of normal saline for control, diazepam 2 mg/kg (standard), and 100, 200, and 400 mg/kg EEAC (test groups) were injected intraperitoneally (i.p.), 30 min before placing them in the center of the maze. The preferences of the animal to open/enclosed arm, average time spent in open arm, and numbers of entries in open arm were compared in each group. Data were statistically analyzed by one-way analysis of variance followed by multiple Dunnett’s test.

Results: The number of entries in open arm and the average time spent in the open arm by the mice is increased by EEAC in a dose-dependent manner.

Conclusion: EEAC has anxiolytic activity.
AMPHOTERICIN B TOPICAL EXTEMPORANEOUS PREPARATIONS FOR THE TREATMENT OF NON-DERMATOPHYTIC ONYCHOMYCOSIS
Authors: PHOJANA KOMESMUNEEBORIRAK , PORNPEN WERAWATGANONE , WALAISIRI MUANGSIRI
Published: January 2021

Objective: At present, the nail preparation to cure onychomycosis, caused by non-dermatophyte molds, is not commercially available in Thailand. The physical and chemical stability of amphotericin B (AmB) extemporaneous preparations in the presence of 30% dimethyl sulfoxide (DMSO) and their in vitro nail permeation was evaluated.

Methods: AmB extemporaneous preparations in the presence of 30% DMSO were prepared from a commercial sterile injection product, and cream or hydrophilic ointment. Physical stability was tested at 30°C for 2 months, or using 6 heating-cooling cycles. The chemical stability and in vitro nail permeation of AmB content were analyzed using high-performance liquid chromatography (HPLC). In vitro nail permeation was performed by applying 3.5 mg/mm2 of the tested formulation on nail clippings for 5 consecutive days.

Results: The AmB cream and ointment extemporaneous preparations containing 30% DMSO, a permeation enhancer, were homogeneous and pale yellow to yellow cream or ointment. The AmB ointment was stable for up to 60 days. The ointment preparation allows in vitro penetration through nails up to 14.17 μg/cm2. The ointment preparation allows significantly better penetration through than the cream preparation due to the presence of DMSO, sodium lauryl sulfate (SLS), and water in the ointment preparation.

Conclusion: The AmB extemporaneous ointment was successfully compounded from a commercial sterile injection product with a beyond-use date of 60 days. The ointment preparation is currently under further investigation for in vivo efficacy.
ANTIFUNGAL AND ANTIBIOFILM ACTIVITY OF 2-BROMO-N-PHENYLCETAMIDE AGAINST CRYPTOCOCCUS NEOFORMANS
Authors: DE MELO THAMARA RODRIGUES , CORDEIRO LAÍSA VILAR , DA SILVA SOUZA HELIVALDO DIÓGENES , DE ATHAYDE-FILHO PETRÔNIO FILGUEIRAS , DE OLIVEIRA-FILHO ABRAHÃO ALVES , FERREIRA SÁVIO BENVINDO , OLIVERIA LIMA EDELTRUDES DE
Published: January 2021

Objective: This study aimed to evaluate the antifungal and antibiofilm of 2-bromo-N-phenylacetamide (A1Br) against Cryptococcus neoformans in vitro.

Methods: The compound was characterized by infrared and 1H-nuclear magnetic resonance spectrometry data. Minimum inhibitory concentration (MIC) was determined using the plate dilution method and biofilm formation inhibition of the crystal violet assay.

Results: A1Br inhibited the growth of C. neoformans with MIC of 0.25 and 0.5 μg/ml and has good antibiofilm activity MIC ×4, with ≥80% inhibition growth.

Conclusions: Thus, A1Br shows potential antifungal and antibiofilm agents for the treatment of infections caused by C. neoformans, as well as the eradication of cryptococcal colonization of medical prosthetic devices.
AN OBSERVATIONAL STUDY OF ENTHESOPATHY IN DRIED HUMAN SCAPULAE
Authors: AGARWAL SUMITA , MOTAGI MANJUNATH V , PAL VISHNU , VAIDYA YUGANTI
Published: January 2021

Objectives: An abnormal ossification process in soft tissues at the attachment site to a bone is called enthesopathy due to biomechanical movements of bone. The present study aimed to observe the calcification of the transverse scapular ligament (TSL) with complete or partial ossification, the presence of the triangular bony growth at the lateral border of scapula and to observe vascular foramen/foramina piercing at the bases of the spine of scapulae.

Methods: An observational study was conducted on dried human scapulae 140 in number (70 right and 70 left) of unknown sex and age, procured from the Department of Anatomy, People’s College of Medical Science and Research Center, Bhopal, and Government Doon Medical College, Dehradun, India. These scapulae were studied to observe enthesopathic changes in them. Measurements were taken with Vernier calipers.

Results: In the present study, we observed the presence of completely ossified TSL with formation of complete suprascapular foramina in 8.57% scapulae. The incidence of triangular bony growth at the lateral border of scapula was found in 40% scapulae of the right side and 32.85% of the left. The incidence of vascular foramina piercing at the bases of the spine of scapulae was 17.14% on the right side and 21.42% on the left side scapulae.

Conclusion: The study provides the descriptive knowledge of enthesopathy in scapulae. The study is of great significance for neurosurgeons and orthosurgeons to carry out various reconstructive surgeries.
Badania reakcji nitrowania toluenu za pomocą mieszaniny kwas azotowy(V)/dichlorometan
Authors: Nastała Andrzej , Maksimowski Paweł , Tomaszewski Waldemar
Published: January 2021

This work has studied the effects on the nitration of toluene by 100% nitric(V) acid and a nitric(V) acid/dichloromethane mixture. The results show that the amount of meta-nitrotoluene decreases with decreases in reaction temperature. From 25 °C to –10 °C the amount of metanitrotoluene was less than for nitrating toluene by a nitric(V)acid/dichloromethane mixture than for nitration by 100% nitric(V) acid. Furthermore, from –20 °C to –30 °C results were similar with 2.6% of meta-nitrotoluene in the reaction products. An excess of nitric(V) acid in the nitration of toluene by the nitric(V) acid/dichloromethane mixture than in nitration by 100% nitric(V) acid. Nitration by the nitric(V) acid/dichloromethane mixture is less exothermic and easier to control than nitration by 100% nitric(V) acid.
Nowe podejście do systemu klasyfikacji materiałów wybuchowych w produkcji, obrocie i magazynowaniu
Authors: Szczygielska Joanna , Gaca Agata , Buczkowski Daniel
Published: January 2021

The classification of explosives in accordance with GHS is based on the system defined in the UN Recommendations on the Transport of Dangerous Goods, Model Regulations. In many cases, classification of explosives depends on certain transport packaging. This approach results in that a number of classified explosives, after removal from the transport packaging, being placed in to another division and compatibility group, what is not communicated by the hazard communication elements appearing on the label. Experts of the GHS Sub-Committee from 2015 have been taking action to change the system of explosives classification, so that the criteria allow for proper assessment of the hazard posed by a specific explosive in a configuration other than for transport.
Scientific study of the pyrotechnic compositions burning process in the laboratory tests
Authors: Barański Krzysztof , Biegańska Jolanta , Biessikirski Andrzej
Published: January 2021

The article discusses the operation of pyrotechnic compositions in electric and nonelectric detonators. Laboratory methods for testing pyrotechnic compositions used to assess their flammability properties and to determine the potential for use as delaying masses in mining detonators are presented. Research on burning pyrotechnic compositions in bulk and compacted state has been discussed. The methodology of individual experiments, their goals and variants has been presented. Results and conclusions from laboratory tests for selected pyrotechnic compositions of the Si-Bi2O3 system were presented. It has been found that both pyrotechnic compositions have the ability for burning process and heat transfer in laboratory tests.
Analysis of environmental impacts of combustion products of some pyrotechnic compositions
Authors: Kukfisz Bożena , Rakus Jakub , Piec Robert
Published: January 2021

The study examined mixtures obtained from ready pyrotechnic articles available on the market in Poland. Samples were taken from various products with different performance characteristics, i.e. pyrotechnic batteries, firecrackers, volcanoes, as well as smoke candles, rockets (including rocket engines), and cold fires. These are the product categories most frequently used by users. The research allowed to determine gaseous combustion products and showed their life cycle in the environment. A comparative analysis of selected pyrotechnic mixtures was carried out in terms of their impact on the climate change of gas products. Using the ICT-Thermodynamic Code program, gaseous combustion products were estimated and the life cycle was analysed using the SimaPro program. Determining the impact on the environment (upon the basis of Ecoindicator 99) allowed to know the scale of the problem and set the direction of development of the pyrotechnic industry, so that importers could compete not only with the price and quality of products offered, but also tried to reduce the potential impact on the environment.
Edificios prefabricados en Chile: diagnóstico energético a 40 años de su construcción. Caso de estudio: edificios KPD, Santiago de Chile
Authors: Vásquez-Manquián Karin Pamela , Decinti-Weiss Alejandra Verónica , Díaz-Huenchuan Marco Antonio
Published: January 2021

KPD residential buildings, although simple and discrete, are emblematic of Chile. Their story in this country starts with an earthquake and is intertwined with the antagonistic governments of Salvador Allende and Augusto Pinochet. These buildings have remained outside current thermal regulations, and have become part of an extensive built housing stock that need to be diagnosed in terms of energy, to align them with domestic thermal requirements and, in this way, improve the quality of life of their inhabitants and contribute to what Chile has already committed to in terms of carbon neutrality. This article presents a thermal comfort evaluation case study of a KPD residential building complex in the Metropolitan Region. Concretely, four buildings are analyzed, each with the same materials and distribution, but with different orientations. The evaluation methodology considered a three-fold approach: regulatory, labeling and subjective and involved their inhabitants in the diagnosis, who had constantly and inexplicably been marginalized in previous analyses of their own homes. The results show discrepancies between the residents’ perception and the comfort range used by the current energy rating system in Chile.
Mejoras en el desempeño energético de edificios en verano mediante la integración de envolventes ventiladas en fachadas norte y cubiertas. El caso de Mendoza, Argentina
Authors: Balter Julieta , Ganem Carolina , Barea Gustavo
Published: January 2021

The proposal of energy efficiency measures in the residential sector in Argentina requires analyzing the architectonic possibilities of building rehabilitation using technologies that reduce energy consumption, that are feasible to implement locally. In regions with high solar radiation levels, as is the case of the city of Mendoza, heat fluxes transmitted inside can be reduced by the natural ventilation of the layers in the envelope, both on facades and roofs, thus obtaining significant savings in consumption for cooling purposes. This work evaluates the potential for improvement with the integration of ventilated envelopes. The work methodology is structured in two stages: i) survey of residential buildings by morphological typology and analysis of rehabilitation possibilities with ventilated facades, considering the exposed envelope surfaces by orientation; ii) simulation of a case study - previously validated with onsite measurements - using the EnergyPlus software. On integrating ventilated facades and roofs important energy savings of around 32% were achieved, considering the building without users (unoccupied). In the case of units on the top floor, with roofs exposed to the outside, energy savings of 260% were recorded.
Rutin Attenuates Acrylamide Induced Neuropathic Pain via Inhibition of Proinflammatory Cytokines, Up-Regulation of Bcl-2 and Down-Regulation of Bax
Authors: Sathuluri Vineela  , Santh Rani Thakur
Published: January 2021

Rutin is a flavonoid of the flavonol type found in many typical plants, such as buckwheat, passion flower, apple and tea. Acrylamide (ACR) is a known industrial toxic chemical that produces neurotoxicity characterized by progressive neuronal degeneration. Rats were randomly divided into Control, ACR, Pregabalin and Rutin treated groups. Male wistar rats were treated with ACR (50 mg/kg/ i.p.) for 4 weeks which produce typical symptoms of neuropathy in rats. Pregabalin (10 mg/kg) and Rutin (50 & 100 mg/kg) were administered orally for 4 weeks after one hour of ACR administration. ACR enhanced the production of reactive oxygen species (ROS). Treatment with Rutin significantly improved neurological score. Rutinsignificantly (p<0.001) attenuated acrylamide induced oxidative stress markers. The expression of Bcl-2 was up-regulated and TNF-α, IL-6 and Bax were down-regulated by rutin treatment. From our results, it can be concluded that rutinshowed an ameliorative effect against ACR induced neurotoxicity in rats through its antioxidant, anti-inflammatory and antiapoptotic actions.
Past Decade Work Done on Cubosomes and its Factorial Design: A Fast Track Information for Researchers
Authors: Shravani Y  , Hindustan Abdul Ahad  , Chinthaginjala  Haranath  , Bhumireddy  gari Poojitha  , Syed Rahamathulla  , Aswarthanarayana Rupasree
Published: January 2021

The objective  of this review  is to explore  the past work done on Cubosomes  as drug delivery  systems  by factorial  design. Cubosomes  are Nanoparticulate  systems  made of amphiphilic  lipids at a certain percentage,  known  as liquid crystals.  They have tightly packed  honeycomb  structures  twisted  into  3D  bilayers.  Cubosomes  can  capture  all  categories  of  the  lipophilic,  hydrophilic,  and amphiphilic  substances  irrespective  of their affinity, by that they fit for delivering all range of drugs with ease. Many works in recent days are concentrating  on Cubosomes  for drug delivery, as it suits all ranges of drugs without much difficulty. Cubosomes  acts as a carrier in drug  delivery  for a wide range  of drugs  and protects  them  from  degradation  issues  like hydrolysis,  oxidation,  and others.  Moreover, numerous  studies  have established  the benefits  of Cubosomes  in nanotechnology,  prolonged-release, and also enhanced  bioavailability. This article reviews about the past work done on Cubosomes using factorial design. Additionally,  many studies need to be performed for the  optimization  of  Cubosomes  for  artificial  cells,  and  biosensors,  etc.  Moreover,  the  rational  design  of  Cubosomes  for  biomedical applications need to be developed. A widespread literature assessment revealed that many reviews and research attempts were made on Cubosomes,  but no review article is still available in bringing the attempts  made on Cubosomes  by factorial design on a single platform. The  factorial  approach  is  used  to  optimize  the  formulation,  which  is  acceptable  and  used  in  the  current  scenario  in  optimizing  the formulations.  So,  the  authors  made  widespread  work  by  referring  to peer-review  journals,  periodicals,  magazines,  and  succeeded  in bringing work done on Cubosomes  in the last ten years by using factorial design. The study concludes and gives a quick reference to the young researchers to get literature on earlier successive attempts done on Cubosomes by factorial design.
Caracterización florística de un paisaje antrópico con árboles remanentes en el Valle Central Occidental de Costa Rica
Authors: Bonilla-Villalobos Verónica
Published: January 2021

Con la finalidad de describir la composición florística de la finca Los Llanos, (renombrada por la UNED, Estación Experimental Los Llanos, según acuerdo Rectoría CR 2019-914), se realizó una caracterización florística del bosque húmedo premontano transición a basal en un paisaje degradado ubicado en la comunidad de Los Llanos, Alajuela. El trabajo se realizó entre los años 2016 y 2017, por un periodo aproximado de siete meses. Se establecieron aleatoriamente 20 parcelas circulares donde se contabilizaron e identificaron todas las especies de plantas con un diámetro (DAP) mayor o igual a 10 cm. Se obtuvo información sobre: a) el estado actual del ecosistema, b) muestreo rápido de especies forestales, c) identidad taxonómica de las especies, d) gremios ecológicos de las especies, e) área basal, f) análisis de diversidad alfa y g) caracterización del suelo y h) recurso hídrico. Se encontró que el sitio es atravesado por la quebrada ojo de agua y cuenta con un bosque ribereño alterado, el cuál colinda con dos nacientes de agua registradas. Gran parte del territorio es dominado por plantas herbáceas, mayoritariamente de las familias Asteraceae, Poaceae, Verbenaceae, así como de cultivos mixtos como Phaseolus vulgaris y Zea mays. El sitio se caracteriza por tener suelos muy pedregosos y arcillosos (vertisoles), una cobertura forestal dispersa, con presencia de algunos árboles con alto valor comercial especialmente cedro (Cedrela), cenízaro (Samanea saman) y guanacaste (Enterolobium cyclocarpum) y el bosque ribereño está compuesto principalmente de especies como roble sabana (Tabebuia rosea), yos (Sapium glandulosum), cedro (Cedrela odorata) y guarumo (Cecropia). Además, la cobertura forestal riparia es discontinua y las áreas de cultivos dentro de la finca. Este estudio encontró una composición florística del bosque transicional muy alterada, pero con algunas especies representativas del Valle Central que pueden colaborar como remanentes para iniciar un proceso de restauración ecológica en la comunidad de Los Llanos.
Atención a estudiante no vidente: Caso en la asignatura de Matemática I para I y II Ciclos
Authors: Rojas Quesada Estibaliz Odilie , Sequeira Salazar Ronald
Published: January 2021

Se presentan los resultados de una experiencia educativa en la atención de estudiantes universitarios ciegos que se están preparando para ser docentes en I y II Ciclos de la Educación General Básica Costarricense. La información corresponde al caso de una estudiante que se encontraba cursando la asignatura de Matemáticas I para I y II Ciclos, en la cual debe desarrollar una mini-clase. A la estudiante se le propone una estrategia didáctica en la que emplee material concreto en el tema de fracciones, pero ella cambia los planes de los investigadores y los reta a realizar ajustes para abordar una propuesta en el tema de operaciones básicas.
Cultivo en suspensión de Mytella guyanensis (Bivalvia:Mytilidae) en Isla Chira, Costa Rica: implicaciones ambientales y biológicas.
Authors: Ureña-Juárez Paul , Diaz Peralta Christian
Published: January 2021

RESUMENLa maricultura artesanal surge en las últimas décadas como una actividad productiva para el desarrollo socioeconómico de las islas del Golfo de Nicoya en Costa Rica. Determinar las condiciones ambientales y biológicas para impulsar el cultivo de Mytella guyanensis representa un gran insumo para el manejo y la comercialización de estos bivalvos de forma sostenible. Se evaluó el crecimiento, la mortalidad y su relación con los parámetros ambientales en un medio de cultivo en suspensión en Isla Chira. Durante 6 meses (octubre 2018-marzo 2019), se registraron los principales parámetros ambientales del medio de cultivo, se realizaron biometrías a 300 individuos de la población cultivada y, además, se estimó la tasa de mortalidad mediante el procesamiento de 60 canastas de mejillón. En términos generales, a) los parámetros físico-químicos monitoreados presentaron condiciones aptas para el cultivo de estos organismos, b) se registró una tasa de mortalidad del mejillón mensual promedio de 13 %±4,5; y c) M. guyanensis alcanzó un tamaño apto para su comercialización y consumo (≥40 mm de longitud) a partir del cuarto mes de cultivo. El crecimiento de M. guyanensis mediante el sistema de producción en canastas suspendidas, tiende a suceder con mayor rapidez con respecto a su crecimiento en bancos naturales. El futuro de la Maricultura, dependerá en gran medida del seguimiento de los parámetros físico-químicos, de la caracterización de rangos óptimos para las especies cultivadas, como también, de la identificación de nuevos sitios aptos para cultivar.
Mediação da informação e suas dimensões dialógica, estética, formativa, ética e política: um fundamento da Ciência da Informação em favor do protagonismo social
Authors: Gomes Henriette Ferreira
Published: January 2021

Estudo analítico da literatura científica que focaliza o fenômeno informação, a mediação da informação, teorias sóciointeracionistas,articulando abordagens de autores que situam a informação e o fazer informacional em uma perspectivasocial em diálogo com abordagens que focalizam a mediação da informação, as teorias sócio-interacionistas, teorias dacomunicação, semióticas e linguísticas, com o apoio da técnica da análise de conteúdo em leituras intensivas e recursivasna identificação de pontos de convergência entre as perspectivas e proposições. Como resultado amplia as dimensõesda mediação da informação, apresentando uma proposição conceitual de informação e discutindo que a efetividade daação mediadora depende da mediação consciente, que busca alcançar suas dimensões dialógica, estética, formativa,ética e política, assegurando o processo de problematização para que ocorra a apropriação da informação e a tomadade consciência, o que contribui para o desenvolvimento e fortalecimento do protagonismo social e permita o acesso,uso e a apropriação da informação em parâmetros democráticos, o que é fundamental ao processo de transformaçõessociais. Nessa perspectiva, ressalta a problematização e a práxis como categorias freirianas que sustentam a importânciada mediação consciente, a formação do profissional e intelectual orgânico do campo, assim como a proposição de se alçara mediação da informação e suas dimensões à condição de fundamento da Ciência da Informação.

Palavras-chave: Dimensões da mediação da informação. Mediação consciente da informação. Informação – Conceito.
Periódicos científicos brasileiros indexados no Google Scholar Metrics
Authors: Pinto Adilson Luiz , Do Canto Fabio Lorensi , Gavron Edson Mario , Talau Marcos
Published: January 2021

Este trabalho tem o objetivo de identificar quantos periódicos científicos brasileiros são indexados pelo GoogleScholar Metrics e o de descrever as características das publicações. As variáveis analisadas são o escopo temáticoe o impacto (índice e mediana h5), a classificação Qualis, os idiomas do conteúdo, a periodicidade e a vinculaçãoinstitucional. Foram recuperados dados de 1.906 periódicos científicos brasileiros contidos no UlrichsWeb.Foi desenvolvido um script para busca e extração automatizada dos dados no sistema. Para os títulos nãoencontrados foi realizada uma busca manual. Foram identificados 1.063 periódicos brasileiros no Google ScholarMetrics, que correspondem a 55% do total pesquisado. Constatou-se que 33% das publicações são de CiênciasHumanas, 17% de Ciências da Saúde e Medicina e 17% de Ciências Sociais; os periódicos com maior média doíndice h5 são Ciências da Saúde (11,34) e Ciências Agrarias e Biológicas (9,11) e aproximadamente 90% do totalde publicações possuí índice h5 inferior a 10. Verificou-se ainda que aproximadamente 50% dos periódicos émantido por universidades públicas federais ou estaduais, 54% publica conteúdo somente em português e 65%é semestral ou trimestral. Pode-se afirmar que o Google Scholar Metrics é uma fonte relevante de análise deimpacto de periódicos brasileiros, principalmente de publicações acadêmicas, das áreas de Ciências Humanas eSociais e sem outro indicador de impacto. No entanto, o uso desse sistema para fins avaliativos oficiais deve serrealizado com cautela, considerando que o sistema apresenta inconsistências e limitações.

Palavras-chave: Google Scholar Metrics. Periódicos científicos brasileiros. Índice h5.
Fontes de informação sobre Gestão de Dados de Pesquisa
Authors: Cunha Murilo Bastos da , Costa Maira Murrieta
Published: January 2021

O artigo apresenta uma bibliografia seletiva e anotada sobre as principais fontes de informação necessárias ao estudo da gestão de dados de pesquisa. Ela está dividida em duas partes; a primeira arrola os livros e manuais e os documentos gerais. Na segunda parte foram listados os documentos relacionados ao fluxo dos dados de pesquisa: políticas de gestão, planos para a gestão de dados, requisitos das agências de fomento, normas e padrões, metadados, fluxos de trabalho, aspectos legais, aspectos econômicos, compartilhamento e reuso de dados, preservação de dados, identificadores dos dados, citação de dados, visualização de dados, usuários de dados e avaliação dos sistemas.

Palavras-chave: Bibliografia. Gestão de dados de pesquisa. Preservação digital
A missão da Ciência da Informação na Era da Pós-Verdade
Authors: Araújo Carlos Alberto Ávila
Published: January 2021

Neste texto são apresentados e discutidos alguns aspectos da realidade informacional contemporânea, marcada pelas questões da pós-verdade e da desinformação. Discute-se o potencial da ciência da informação para estudar e propor ações relacionadas com essa realidade, a partir dos três modelos de estudo existentes na área: o físico, o cognitivo e o social. Identifica-se a necessidade, a partir da noção de conhecimento e ignorância de Edgar Morin, de se promover um avanço na ciência da informação em direção a uma dimensão veritística, tal como formulado por Jonathan Furner. Conclui-se, a partir das ideias de Theodor Adorno, que a ciência da informação atual precisa ter como centro de sua missão a questão da verdade e do combate à circulação de informações falsas.

Palavras-chave: Pós-verdade. Desinformação. Ciência da informação. Epistemologia da ciência da informação.
Democracia documentária e Teoria da Não-conceitualidade: filosofia e práxis
Authors: Saldanha Gustavo
Published: January 2021

O objetivo desta pesquisa é discutir a construção das possibilidades de problematizar a teoria da não-conceitualidade naCiência da Informação no âmbito da organização do conhecimento, com vistas a desenvolver uma abordagem políticocríticada democracia documentária. Por meio da abordagem metodológica da filosofia da linguagem ordinária, a pesquisaintegra a logologia de Bárbara Cassin, a teoria política de Maria Nélida González de Gómez e a teoria do conceito de EmanueleTesauro. Os resultados colocam em diálogo a organização ordinária dos saberes socialmente oprimidos e a Constituiçãobrasileira, estabelecendo a práxis documental como forma de luta e resistência na sociedade democrática.

Palavras-chave: Democracia documentária. Teoria da não conceitualidade. Organização ordinária dos saberes socialmenteoprimidos. Teoria do conceit. Logologia.
Mediação da leitura e alteridade na Educação Literária
Authors: Cavalcante Lidia Eugenia
Published: January 2021

Discute a mediação da leitura na perspectiva da educação literária a partir da compreensão do conceito de alteridade. Tomacomo referência conceitual os estudos filosóficos de Emmanuel Lévinas e Paul Ricoeur acerca da alteridade. Apresenta comoquestão de pesquisa: qual o lugar da alteridade na mediação da leitura na educação literária contemporânea, nesses temposdifíceis de individualismo, isolamento, silenciamento e de subtração de direitos? Discute as implicações da mediação daleitura levando-se em consideração as subjetividades do leitor em relação ao texto e às linguagens. Busca compreendercomo a ação pedagógica na educação literária pode contribuir no que concerne à dialogicidade das experiências de cadaser humano. Conclui que o ato de ler pode contribuir para o desenvolvimento de saberes reflexivos e críticos que alicerçama construção do conhecimento, gerando modos de resistência às visões totalitárias, centralizadoras e assimétricas queteimam em reduzir os direitos humanos e a autonomia dos sujeitos. A leitura, portanto, pode propor outro caminho pormeio da linguagem e da cultura, não subordinada às formas de dominação.

Palavras-chave: Educação literária. Mediação de leitura. Alteridade.
Effect of Practical Learning on Creative Thinking Skills of High School Students on Acid-Base
Authors: Alwi Sayid Z. S. , Suherman Suherman
Published: January 2021

This study aims to determine the effect of practical learning on the creative thinking skills of class XI students on acid-base material at SMAN 7 Palu. This type of research was a quasi-experimental research with equivalent control group design. Sampling in this study was a purposive random sampling technique. The sample consisted of two classes students in XI MIA 2 as the experimental class (n = 24) and students in class XI MIA 4 as the control class (n = 24). Data from students' creative thinking using the one-party hypothesis testing, the right side were in this study used the statistics application and obtained sig. (2-tailed) 0,000 data based on this decision, the hypothesis is accepted if the sig (2-tailed) value is smaller than 0.05 so that it can be concluded that there is a positive effect using practical learning on the creative thinking ability of class XI students on acid-base material at SMAN 7 Palu.
Analysis of Well Water Quality based on Physics, Chemical, and Microbiology Parameters in IAIN Tulungagung Area
Authors: Wahyuni Tutik S. , Kartikasari Desi
Published: January 2021

Water as a natural resource is needed in life. Nowadays, the need for freshwater is increasing. Meanwhile, most people fulfill their daily water needs from well water. This study aims to determine the quality of well water in the IAIN Tulungagung campus area based on physical, chemical, and biological parameters. This type of research is a quantitative descriptive. A total of 12 points from 4 stations were chosen by random sampling. Laboratory test results were compared with PerMenKes RI No. 492/MENKES/PER/IV/2010 and PerMenKes RI No. 32 Tahun 2017. The results of the study show that (1) two sources of water do not qualify as clean water based on physical parameters because the turbidity value and total dissolved solids (TDS) exceeds the quality standard, (2) five sources of water do not qualify as water clean based on chemical parameters because the Fe content exceeds the quality standard and/or low dissolved oxygen (DO) concentration, and (3) four wells do not meet bacteriological tests for the amount of coli fecal bacteria and total coliform. Well water in the IAIN campus area has decreased water quality caused by domestic waste.
A Quest for “Justice” in Capital Punishment: A Socio-Legal Study of the Nirbhaya Gangrape Case
Authors: Irfan Samra
Published: January 2021

The December 16, 2012 gang rape case in India’s capital ignited fierce discussion on women’s rights, safety measures as well as the punishment for the rapists. A major question stemming from this case and elaborated in this paper is: is capital punishment for a rapist an effective measure, as a form of “justice” for the victim? The paper concludes that capital punishment should be abolished even for gruesome crimes like rape and it further raises the question whether capital punishment can serve as a reform tool for the existing and oftentimes dysfunctional criminal system in India. Through a thorough analysis of Mukesh & Another Vs State of NCT of Delhi and others (known as the Nirbhaya gang rape case), the paper explores capital punishment for the rapist from a socio-legal and cultural perspective. The case particularly becomes important as, along with other issues, it is concerned with the question of rights of the victim vis-à-vis the rights of the offender. In other words, the paper delves deeper into the conflict between the victims’ interests and the right of the offender in the justice system by examining who is responsible for what and to what extent. Taking a human rights approach, the paper examines the human rights jurisprudence in India as well as in international laws. Further, it maps the social and historical perspective revolving around rape victimhood and gender along with arguments that have been predominant for and against capital punishment, particularly for rapists in an Indian context.
Prevention of nosocomial transmission and biofilm formation on novel biocompatible antimicrobial gloves impregnated with silver nanoparticles synthesized using Eucalyptus citriodora leaf extract
Authors: Paosen Supakit , Lethongkam Sakkarin , Wunnoo Suttiwan , Lehman Nussana , Kalkornsurapranee Ekwipoo , Voravuthikunchai Supayang
Published: January 2021

Failure in the prevention of cross-transmission from contaminated gloves
has been recognized as an important factor that contributes to the
spread of several healthcare-associated infections. Ex situ coating
process with silver nanoparticles (AgNPs) using Eucalyptus citriodora
ethanolic leaf extract as reducing and capping agents to coat glove
surfaces has been developed to prevent this mode of transmission.
Elemental analysis of coated gloves showed 24.8 Wt% silver densely
adhere on the glove surface. The coated gloves fully eradicated
important hospital-acquired pathogens including Gram-positive bacteria,
Gram-negative bacteria, and yeasts within 1 h. The coated gloves showed
significant reduction, an average of 5 logs when tested against all
standard strains and most clinical isolates (p < 0.01).
Following prolonged exposure, the coating significantly reduced the
numbers of most adhered pathogenic species, compared with uncoated
gloves (p < 0.0001), which was observed by fluorescence
microscopy. Scanning electron microscopy further confirmed that AgNPs
coated-gloves reduced microbial adhesion of mixed-species biofilms,
compared with uncoated gloves. A series of contamination and
transmission assays demonstrated no transmission of viable organisms.
Biocompatibility analysis confirmed high cell viability of HaCaT and
L929 cells at all concentrations of AgNPs tested. The coated gloves were
non-toxic with direct contact with L929 cells.
Interlayer Dural Split Technique for Chiari I Malformation Treatment in Adult -- Technical Note
Authors: Florian Ioan Alexandru , Pop Mihaela Maria , Timis Teodora Larisa , Florian Ioan Stefan
Published: January 2021

Objective: To present an alternative surgical technique in treating
cases of Chiari I Malformation with mild-to-moderate syringomyelia after
decompressive suboccipital craniectomy: incising only the outer layer of
the dura mater, then dissecting it from the inner layer without opening
the latter. Methods and Results: We utilized this technique in a short
series of three cases who were admitted in our department for mild
symptoms such as intermittent headache and dissociated sensory loss in
the upper limbs, caused by a Chiari Malformation Type I. The patients
were placed in the sitting position. We performed a reduced median
suboccipital craniectomy and resection of the posterior arch of C1
adapted to the level of tonsil descent, from a limited superior half to
a complete resection. Afterwards, we incised the outer dural layer,
while sparing the inner one. Using a fine dissector, we then split apart
the outer and inner layers to the margin of the craniectomy. Through the
transparency of the inner layer and the arachnoid, the cerebellum and
the medulla were visible and pulsating. An autologous fascia duraplasty
was then performed. The postoperative course was favorable in all cases,
patients being discharged without any deficits and with complete symptom
resolution. Conclusions: Interlayer dural split technique can be used
effectively in treating symptomatic cases of type I Chiari malformation
in adults, with mild-to-moderate syringomyelia. It is less invasive than
opening the dura and possibly more effective than decompressive
craniectomy and C1 laminectomy alone. This technique must be validated
in a larger case-control series.
Are pedigree-based mutation rates the Rosetta Stone of molecular ecology? Promises and pitfalls of whole genome comparisons among closely related individuals.
Authors: Yoder Anne , Tiley George
Published: January 2021

Germline mutations are the raw material for natural selection, driving
species evolution and the creation of earth’s biodiversity. Life on
earth would stagnate without this driver of genetic diversity. Yet, it
is a double-edged sword. An excess of mutations can have devastating
effects on fitness and population viability. It is therefore one of the
great challenges of molecular ecology to determine the rate and spectrum
by which these mutations accrue across the tree of life. Advances in
high-throughput sequencing are providing new opportunities for
characterizing these rates and patterns within species and populations,
thus informing essential evolutionary parameters such as the timing of
speciation events, the intricacies of historical demography, and the
degree to which lineages are subject to the burdens of mutational load.
Here, we will focus on the applications and limitations of whole-genome
comparisons among closely related individuals in what are typically
described as “trio” analyses for the detection of germline mutations
as they arise in real time. By sequencing and comparing whole-genomes
generated for individuals of known relatedness – typically, parent to
offspring – investigators can ideally count and characterize mutations
as they appear per generation. The promise for gaining insight into
classic hypotheses of molecular evolution is high, though so too is the
cost. Namely, the technical challenges are daunting given that
pedigree-based studies are essentially searching for needles in a
haystack. Even so, the opportunities are so enticing, and the field so
young, we can say with confidence that fundamental insights have only
just begun to emerge.
COVID-19 and Education in Asia and the Pacific: Guidance Note
Authors: Jagannathan Shanti , Geronimo Dorothy
Published: January 2021

This guidance note underscores the potential of education technology (EdTech) solutions in transforming learning, teaching, and training systems during and after the coronavirus disease (COVID-19) pandemic. Since the COVID-19 outbreak, governments have been coping with and responding to many challenges posed by the closure of education institutions. Building on key principles and solutions proposed by several international agencies, the guidance note provides suggestions for developing countries in Asia and the Pacific to initiate reforms to improve quality, relevance, and inclusion in education. It is one of a series produced by the Asian Development Bank for key sectors and thematic areas.
The role of cardioenzymes in the diagnostics of infectious heart diseases
Authors: Babachenko I. V. , Sharipova E. V. , Alekseeva L. A. , Chuprova S. N. , Bessonova T. V. , Konstantinova Yu. E.
Published: January 2021

Purpose: to evaluate the importance of increasing cardioenzymes in the diagnosis of infectious heart lesions.

Object and methods: Under observation were 71 children aged 3 to 17 years (average age – 6.6 ± 0.4 years) who received treatment at the clinic of Pediatric Research and Clinical Center for Infectious Diseases. All children in the acute period of illness and 49 patients with follow-up history were identified with levels of creatine phosphokinase (CPK), MВ fractions of creatine phosphokinase (CPK-MВ), lactate dehydrogenase (LDH), C-reactive protein (CRP), aspartate aminotransferase (AST). Follow-up observation and examination of patients was performed after 1 month and after 1 year. All children were examined for a wide range of pathogens of acute respiratory viral infections, active herpes virus infections (EBV, CMV, HHV-6 type), B19 parvovirus, Chlamydophila pneumoniae, Mycoplasma pneumonia, enteroviruses and bacterial respiratory pathogens. All examined patients underwent electrocardiography and echocardiography.

The results of the study. In the examined patients with an increased level of “cardioenzymes” (CPK-MВ, LDH, AST) against the background of acute respiratory infection (ARI), a wide range of diseases was established with damage to both the upper respiratory tract and lower (bronchitis, bronchiolitis, pneumonia), and also other infectious nosologies, including respiratory syndrome (infectious mononucleosis, enterovirus and parvovirus infection). The etiological structure was dominated by a group of herpesvirus (53%) and bacterial infections (25%), as well as their combinations. An analysis of the dynamics of the main biochemical and hematological parameters characterizing the severity of the systemic inflammation syndrome (leukocytes, SRE, CRP, CPK), as well as reflecting myocardial injuries and used in cardiology practice (CPK- MВ, LDH, AST), revealed a long-term (within 1 year observations) the preservation of a moderately elevated level of CPK-MВ, unlike other indicators that returned to normal within 1 month. An increase in CPK-MВ was recorded in 79% of patients with drip infections, while the average level of CPK-MВ in the total sample exceeded the normal values by 1.8-2.4 times.

Conclusion. It was found that elevated levels of CPK-MВ and LDH can be used as criteria for the formation of dynamic observation groups and early rehabilitation.
Convulsive syndrome in the post-vaccination period: is there a connection with the vaccine?
Authors: Nacharova E. P. , Kharit S. M. , Ruleva A. A.
Published: January 2021

The article describes the characteristics and classification of adverse events after immunization (AEFI) according to the latest WHO recommendations. The registration systems for AEFI in the USA and in Russia are described. Particular attention is paid to the interpretation of the convulsive syndrome that developed after vaccination. Four clinical cases of the development of convulsive syndrome in children hospitalized at the Pediatric Research and Clinical Center for Infectious Diseases of Russia (St. Petersburg) in the postvaccination period are presented. The criteria for differential diagnosis of the described diseases are indicated. Only a search for the etiology of the disease allows us to assess the relationship with vaccination, timely conduct adequate therapy and generate objective information on the safety of vaccines. There is a need to register all episodes of seizures after vaccination and introduce new methods for registering PPI, as well as creating a system of statistical accounting of background health conditions (convulsions, allergies) of the population of the Russian Federation of various age groups.
Frequency of infectious complications and features of systemic inflammatory response in patients with prolonged disorders of consciousness
Authors: Dryagina N. V. , Kondratyeva E. A. , Kondratyev S. A. , Markovkina I. A. , Potemkina E. G. , Kondratyev A. N.
Published: January 2021

Objective: investigate epidemiology of infectious complications, intensity of antibacterial therapy, and features of the systemic inflammatory response in patients with prolonged disorders of consciousness.

Materials and methods: retrospective case histories analysis of 102 patients with prolonged disorders of consciousness who were treated in the department of anesthesiology and intensive care of Polenov Neurosurgical Institute from 2010 to 2019.

Results: during hospitalization all patients (100%) had signs of tracheobronchitis, 86 patients (84,3%) had urinary tract infection, 34 (33,3%) pneumonia, 10 patients (9,8%) meningoventriculitis, and in 9 (8,8%) cases sepsis was diagnosed. Identified bacterial complications required systemic antibacterial therapy. With an average length of hospital stay of 51±42 days, duration of antibiotic therapy was 37±41 days. One-component therapy was applied in half of the cases (54%), slightly less often (43,2%) treatment consisted of two antibiotics, in some cases patient’s condition required prescription of three antibiotics (2,8%). Even in the absence of a focus of infection, temperature and laboratory markers of inflammation in blood samples of patients with prolonged disorders of consciousness were higher than the reference values. CRP was increased with addition of any bacterial complications. Count of white blood cells significantly increased only in case of pneumonia and sepsis. Procalcitonin test was positive in 16,6% observations of urinary tract infection, 30,4% of pneumonia, and 28% of meningoventriculitis.

Conclusion: most informative proinflammatory marker of bacterial complications in patients with prolonged disorders of consciousness was CRP. Mild leukocyte response can be explained by immunosuppression in long-term ill patients. Limited value of procalcitonin test may be due to the insufficiency of the semi-quantitative method sensitivity with a threshold level of 0,5 ng/ml, as well as reduced proinflammatory response to local infection in patients with prolonged disorders of consciousness as a result of massive antibacterial therapy, colonization of opportunistic microflora and presence of sympathicotonia (non-infectious systemic inflammatory reaction).