bluuebunny/crossref_metadata_2025 huggingface dataset:
The influence of the TBX6 gene on the development of congenital spinal deformities in children
Authors: Khalchitsky Sergei E. , Vissarionov Sergei V. , Kokushin Dmitry N. , Muldiiarov Vladislav P. , Khusainov Nikita O.
Published: October 2021

BACKGROUND: Congenital deformities of the spine are a group of serious congenital defects of the vertebrae, which can manifest themselves in the clinical picture as an isolated pathology of the axial musculoskeletal system, and are associated with congenital defects of internal organs and other systems. Recently, the TBX6 gene has been identified as the genetic cause of congenital scoliosis in about 11% of cases. This subtype of scoliosis is classified as TBX6-associated congenital scoliosis. The TBX6-associated congenital scoliosis phenotype is characterized by butterfly-shaped vertebrae and hemivertebrae in the lower thoracic and lumbar regions without pronounced malformations of the spinal cord.
AIM: Our aim is to study and evaluate data from foreign and domestic scientific publications devoted to the study of the candidate gene for congenital scoliosis TBX6.
MATERIALS AND METHODS: The following databases of scientific publications such as PubMed, Cochrane Library, Web of Science, SCOPUS, MEDLINE, e-Library, Cyberleninka were used to write this review. The inclusion criteria were systematic reviews, meta-analyses, multicenter studies, controlled cohort studies, uncontrolled cohort studies of patients with congenital spinal deformities. The exclusion criteria were clinical cases, observations, conference proceedings, congenital scoliosis in genetic syndromes, congenital scoliosis associated with defects of the nervous system.
RESULTS: In order to achieve this goal, 70 scientific publications were studied relating to the data analysis of the candidate gene for congenital scoliosis TBX6. Among 49 publications that were identified, 2 were domestics, and the rest were foreign publications. These studies provided information on the molecular analysis of genes that cause congenital spinal deformities in humans and animals.
CONCLUSIONS: An analysis of the published research work on this topic indicates the presence of a significant effect of mutations in the TBX6 gene, leading to the appearance of congenital scoliosis.
Advances in elucidating the genetic contribution to the development of congenital spinal deformities and the molecular etiology of clinical phenotypes may uncover the opportunities for further refinement of the classification of signs of congenital scoliosis in accordance with the underlying genetic etiology.
First metatarsal elevation after subtalar arthroeresis in children with flatfeet
Authors: Sapogovskiy Andrey V. , Boyko Aleksey E. , Rubtsov Aleksey V. , Rubtsova Nataliya O.
Published: October 2021

BACKGROUND: Arthroereisis of the subtalar joint is a common surgical option for children with flat feet. Along with all the advantages of arthroereisis of the subtalar joint, the indications for surgery, the optimal age for surgical treatment, as well as secondary deformities of the forefoot that occur after treatment are debatable.
AIM: The aim of this study was to analyze the frequency and degree of I metatarsal elevation after arthroereisis of the subtalar joint in children.
MATERIALS AND METHODS: The study group included 106 patients / 202 feet who were treated at the H. Turner Pediatric Orthopedic Institute for the period from 2015 to 2019. The average age was 11 years (8; 13). Arthroereisis of the subtalar joint was performed in two variants: arthroereisis with a locking screw in the calcaneus 44 patients / 83 feet and arthroereisis with a locking screw in the talus 62 patients / 119 feet. An analysis was made of the incidence of I metatarsal elevation after arthroereisis of the subtalar joint. The relationship between the degree of elevation of the first metatarsal bone and the main clinical and radiological characteristics of the feet at different times after surgical treatment was analyzed.
RESULTS: The frequency of elevation of the I metatarsal bone with the use of a calcaneal locking screw was 20.7%, and with the use of a talar locking screw, the frequency is 51.6%. Clinical manifestations of elevation of the I metatarsal bone took place when the amount of elevation was more than 65% of the size of the head of the I metatarsal bone. At a period of 23 years after the operation, elevation of the I metatarsal bone were noted in 15.9%. A statistically significant correlation (Spearman coefficient) was noted between the degree of elevation of the I metatarsal bone and the following parameters: anteroposterior Meary angle (0.360), lateral Kite angle (0.367), lateral Meary angle (0.378), foot arch angle (0.344), tibio-talar angle (0.351), Friedlands index (0.402).
CONCLUSIONS: Incidence of the first metatarsal bone elevation reaches 51% of the in patients in the immediate follow-up period after performing arthroereisis of the subtalar joint. Elevation of the first metatarsal bone developed dorsal bunion with an elevation value of more than 65%. The degree of elevation of the first metatarsal bone has a positive correlation with the degree of planovalgus deformity correction. Elevation of the first metatarsal bone tends to decrease up to 15% in the long-term follow-up after surgical treatment.
Painful Points of Russian Strategic Development
Authors:   Central Aerohydrodynamic Institute named after Professor N.E. Zhukovsky, Gusev Alexander B. , Shiryaev Alexey A. ,   PJSC "Russian Post"
Published: October 2021

The paper examines the external dependence of the Russian economy in the context of foreign sanctions, the withdrawal of capital from the Russian Federation abroad, the implemented management models of the largest domestic companies (mining sector, banks, retail, communications) and the attraction of cheap labor resources in the interests of domestic business. The thesis that a significant segment of the national economy does not de facto belong to the country is substantiated. It is determined that foreign citizens are allowed to make important corporate decisions at the system level, including attracting foreign labor and withdrawing capital abroad. The example of PJSC "Magnit" shows the replacement of Russian management with a foreign one in the context of the sanctions imposed against the Russian Federation. It is estimated that as of the end of 2020, about 50% of the country's GDP has been accumulated and placed abroad in the form of direct and portfolio investments from the Russian Federation. The response measures taken in the Russian Federation to foreign sanctions pressure could not reverse this negative situation. The replacement of the indigenous population of the Russian Federation by labor migrants with their gradual consolidation on the territory of the country in the future may lead to social and political risks that can manifest themselves most extensively during the internal crisis. The implementation of a nationally oriented scenario of socio-economic development remains difficult. This course of development can be implemented if the current model of the functioning of the national economy changes.
Institution of Higher Education and Science as a Factor of Economic Development
Authors:   Southern Federal University, Maskaev Artyom A.
Published: October 2021

The modern economy is undergoing a structural transformation that enhances the role of knowledge and technology for economic development. Knowledge and technologies are created by researchers who received professional training in universities. The higher education system in Russia is changing similar to those in Western countries earlier. Institutional design should analyse knowledge about management routines, values, working rules, and the functioning of the institutional environment. The institutions operating in society can be identified by studying the narratives of the actors and the explanations for their actions. In the article, the in-depth interview is used for studying institutional changes in education and science. Data collected in projects «Identification of institutions and organizational mechanisms for the merger of universities in the context of the socio-economic development of the region» (10 interviews) and «Institutional traps of optimization of the sphere of education and science» (20 interviews, 3 expert focus group interviews). The narrative analysis identified interest groups in education and science that are involved in the functioning of institutional traps. The presence of special interest groups is an integral attribute of institutional traps that arise in conditions of quasi-optimal equilibrium. Combining research data shows the importance of the institution of higher education and science for economic development.
Labor Markets in Resource-Type Regions
Authors:   Kemerovo State University, Kurbatova Margarita V. , Donova Inna V. ,   Kemerovo State University
Published: October 2021

The modern economic literature has accumulated enough data indicating that labor markets have local specifics, and a single all-Russian labor market is an abstraction. Therefore, the characterization of the Russian labor market as a system of separate regional markets is very important. The purpose of this paper is to determine the functional characteristics of the labor markets of resource-type regions, to identify the features of their state. We used Rosstat data for 2005–2006, 2008, 2013, 2016–2019, as well as microdata from a sample labor force survey conducted by Rosstat in 2019. It is shown that the factor of resource dependence has some effect on the parameters of regional labor markets, but only in combination with other factors (climatic, demographic, spatial, structural and sectoral). In various regions the influence of this factors can be very different. The cluster analysis made it possible to identify some effects of the influence of the resource dependence on labor markets. Firstly, only a very high level of resource dependence of regions is accompanied by a positive and complex influence on regional labor markets. Secondly, resource dependence of regions provides labor market parameters at least at the national average. From the point of view of state regulation labor markets in regions with a high level of resource dependence deserve special attention. At the same time, the main area of activity should be efforts to diversify the economy at the expense of resource rent. This requires the development of new approaches to the interaction of regional authorities with mining companies based in resource-type regions.
The Effect of Organizational Culture and Readiness to Change on Organizational Entrepreneurship: The Role of Competence
Authors: Diwanti Dyah Pikanthi , Suryanto Suryanto , Iswati Sri , Agustina Tri Siwi , Notobroto Hari Basuki
Published: October 2021

Research aims: The purpose of this study is to reveal/investigate how the organizational culture changes the readiness of human resources through entrepreneurial competence to run an organization. At present, the organization's existence is very competitive with other organizations, making human resources a strategic resource owned by the organization. Therefore, organizations must be able to respond to many events that cause changes in the environmental forces that influence them.Design/Methodology/Approach: The type of research is quantitative research. This study used a questionnaire as the survey technique. The analysis of this research was carried out by conducting a classic assumption test, including the multicollinearity test, heteroscedasticity test, and normality test. Furthermore, the data were analyzed employing multiple linear regression analysis, namely the coefficient of determination test (R2), simultaneous significance test (F), and the test of the significance of individual parameters (T). Intervening variables were tested with path analysis and multiple tests.Research findings: This study’s results revealed that organizational culture, readiness for change, and competence positively and significantly influenced organizational entrepreneurship. Organizational culture and/or readiness for change with competence as an intervening variable also positively and significantly influenced organizational entrepreneurship. Organizational entrepreneurship was influenced by 64% by organizational culture and readiness for change in human resources. Meanwhile, the remaining 36% was explained by other variables outside this study’s model.Theoretical contribution/Originality: The novelty of this research is that organizational entrepreneurship is a reference for business independence in an organization.Practitioner/Policy implication: Organizational entrepreneurship exists in organizations that have business entities for organizational independence.
A randomized, prospective, open label comparative study of the efficacy of azilsartan and ramipril in the management of hypertension in patients with type-2 diabetes mellitus
Authors: Siddiqua Husna , Subhani Ghulam
Published: October 2021

Background: Patients with diabetes are prone to have hypertension. Hypertension is risk factors for complications of the vascular system, cardiovascular diseases and leads to atherosclerosis. It has been estimated that the diabetics tend to have about two times more risk of having hypertension than the general population. Objective of current study is to study and compare the efficacy of azilsartan and ramipril in the management of Hypertensive patients with type 2 diabetes mellitusMethods: randomized, prospective, open label comparative study was carried out among 60 known cases of diabetes mellitus type-2 with hypertension. Patients were randomly allocated into two groups: group-A (N=30) taking ACE Inhibitor tablet ramipril 5 mg Once daily orally. Group-B (N=30) taking angiotensin II receptor antagonist tablet azilsartan 40 mg once daily orally. At the commencement of the trial, patients were subjected to thorough clinical examination with necessary investigations and base line values were recorded.Results: Both the groups were comparable for age, sex and treatment taken. There was a significant reduction in the mean arterial pressure (17.43 for azilsartan group vs. 14.5 for ramipril group) (mmHg), creatinine clearance (mean reduction of 18.8 for azilsartan group vs. 13.94 for ramipril group), and urinary albumin excretion (mean reduction of 29.74 in azilsartan group vs. 17.25 for ramipril group). In azilsartan group the reduction was more in all parameters compared to ramipril group without effecting renal parameters.Conclusions: Azilsartan was more effective in reducing the mean arterial pressure (mmHg), creatinine clearance as well as urinary albumin excretion in Hypertensive patients with Type 2 diabetes mellitus without effecting renal parameters.
Clasificación química y geotermométrica de sulfuros del depósito aurífero Mina Pilar (Greenstone Belt, Cuadrilátero Ferrífero, Brasil)
Authors: Ríos-Guerrero Johanna , Ballesteros-Camaro Carlos Andrés
Published: October 2021

El Cuadrilátero Ferrífero es ampliamente conocido por sus depósitos de oro de clase mundial de edades arcaicas, clasificados principalmente como de tipo oro orogénico y epigenético. Estos depósitos están hospedados en una secuencia de rocas meta-volcanosedimentarias del grupo Nova Lima, principalmente en la Formación Ferrífera Bandeada (BIF), fuertemente sulfurada con pirita ± pirrotita ± arsenopirita ± calcopirita + Au, donde los cuerpos mineralizados se encuentran controlados por estructuras regionales con orientación NE y vergencia NW, asociados a alteraciones hidrotermales que exhiben zonación lateral. En el depósito pilar, el oro se encuentra diseminado en la Formación Ferrífera Bandeada y como oro libre en venas de cuarzo + carbonato asociado a los sulfuros, principalmente a la arsenopirita. Los principales sulfuros corresponden a pirrotita, pirita, calcopirita y arsenopirita, orientados según la foliación milonítica S3 en las rocas. Las asociaciones minerales que caracterizan a los halos de alteración hidrotermal son distribuidas según la posición de los cuerpos mineralizados, denominados como zona de cloritización (distal), carbonatización (intermedia) y sericitización (proximal). Las características de las composiciones químicas de los sulfuros relacionados a las fases minerales hidrotermales fueron realizadas a partir de los resultados obtenidos por análisis de microsonda electrónica. Los procesos hidrotermales asociados con la formación de la mineralización, según la paragénesis de sulfuros (arsenopirita ± pirrotita ± pirita ± oro (electrum)) revelan un equilibrio químico en el intervalo de temperatura entre 363°C hasta 471°C.
Doble evaluación de la susceptibilidad por movimientos en masa basada en redes neuronales artificiales y pesos de evidencia
Authors: Goyes-Peñafiel Paul , Hernandez-Rojas Alejandra
Published: October 2021

Los movimientos en masa son la amenaza natural más frecuente en zonas tropicales y son causantes de graves daños en la infraestructura vial, pérdida de vidas humanas y consecuencias económicas. Por lo tanto, una evaluación cuantitativa y confiable de la susceptibilidad por movimientos en masa es esencial para el desarrollo y planeación territorial. En este trabajo se estudia el cálculo de la susceptibilidad con un bajo nivel de incertidumbre a partir de la integración metodológica de Pesos de Evidencia con las Redes Neuronales Artificiales. El primero se usó para extraer los valores de los pesos de las variables y el inventario de movimientos en masa, y el segundo para establecer una relación no lineal entre los factores condicionantes y el inventario puntual de movimientos en masa realizado a partir del estudio geológico y geomorfológico del municipio de Popayán. Esto genera una doble verificación que permite extraer las características de las variables categóricas y continuas para generar relaciones más precisas de susceptibilidad, evitando la multicolinealidad y el uso de factores no significantes a partir del Análisis de Componentes Principales. Para estudiar la influencia de las variables, se analizaron dos propuestas metodológicas, la primera con dos variables y la segunda con cinco variables explicativas. Para cada una de ellas se aplicaron los métodos cuantitativos de Regresión Logística, Perceptrón Multicapa y Red Neuronal Profunda como elementos de doble verificación. Los resultados fueron evaluados a partir de la curva Característica Operativa del Receptor para cada modelo, encontrando que las redes neuronales profundas tienen un valor de Área Bajo la Curva de 0,902 y 0,969 para las propuestas 1 y 2 respectivamente, superando al método de Pesos de Evidencia usado convencionalmente y a la Regresión Logística como métodos cuantitativos.
Inferencias del factor fotoeléctrico (PEF) en registros de pozo con machine learning
Authors: Pardo-Díaz Mauro Felipe , Vargas-Jimenez Carlos Alberto
Published: October 2021

Los registros de pozo convencionales son importantes para la realización de análisis petrofísicos, amarres sísmicos y correlación estratigráfica. El presente estudio propone una metodología para realizar predicciones en estos registros haciendo uso de machine learning (ML), una herramienta altamente aplicada en múltiples disciplinas. El software de entrenamiento utilizado fue WEKA (Waikato Environment for Knowledge Analysis), en el que se generó un modelo para la predicción del registro de Absorción Fotoeléctrica (PDPE o PEF), a partir de tres atributos, los registros de Rayos Gamma (GRGC), Densidad (DEN) y Corrección de Densidad (DCOR). Esta metodología fue aplicada a registros de pozo de la Formación San Fernando, cuya unidad equivalente sería la Formación Mirador, en el sector sur-occidental de los Llanos Orientales de Colombia. Fueron usados los registros de trece pozos para hacer el entrenamiento del modelo y otros seis pozos fueron usados para evaluar el desempeño de este. Los resultados confirman la posibilidad de correlacionar registros que miden características diferentes en las rocas y evidencian que las inferencias en registros de pozo con ML requieren un filtrado minucioso para tomar la tendencia de los datos, y una optimización clara para prevenir el sobreentrenamiento en el modelo.
Cambios estructurales causados por los buzamientos de rampas laterales en cinturones fallados y plegados
Authors: Orjuela Miguel Ángel , Martínez-Sánchez Dilan Arturo , Jiménez Giovanny
Published: October 2021

Transverse zones are tectonic structures parallel or oblique to the shortening direction. Lateral ramps are inherited tectonic structures and are comprised in a transverse zone. During shortening transverse zones are usually confused with simple strike-slip faults. We evaluated 36 analogue models under brittle conditions using two frontal ramps connected by a lateral ramp at different inclinations (30°, 45°, and 60°) to identify lateral ramps characteristics in the fold and thrust belts. The experiments were conducted in a subduction-type sandbox, using dry sand and a rigid block, representing a brittle crust and the backstop. During shortening, faults and folds related grow parallel to frontal ramps. Significative plunges correlate with the inclination of the lateral ramp. The oblique faults dipped along the direction opposite to the lateral ramp, while the normal faults parallel to the lateral ramp only occurred when linked to lateral ramps with high inclinations. The inclination of the lateral ramp controls the plunge and rotation of the folds and thrust structures. Regardless of the lateral ramp inclinations, in map view, the main characteristics used to identify lateral ramps are i) disrupted structures along the strike in the lateral ramp area and ii) oblique faults related to frontal ramp structures.
Cartografía de índices indirectos de manifestaciones de hidrocarburos en el Golfo de Guacanayabo, Cuba
Authors: Álvarez-Ortiz Moraima , Leyva-Ramos Ernesto , Rodríguez-Miranda Willy Roberto
Published: October 2021

La necesidad de disponer de reservas gaso-petrolíferas es imperiosa en el mundo contemporáneo y en el caso de Cuba la situación se acentúa debido a factores externos. Por esta razón numerosas investigaciones son realizadas en el territorio nacional para localizar estructuras favorables donde puedan encontrase acumulaciones de hidrocarburos. El objetivo de esta investigación ha sido estudiar los sedimentos marinos del Golfo de Guacanayabo (Cuba Oriental), los indicios de hidrocarburos en los fondos marinos y el establecimiento de las áreas de mayor interés. Para este estudio se ha combinado la batimetría y la sísmica de reflexión de alta resolución para realizar la cartografía de estructuras anómalas clasificadas como posibles pockmarks y volcanes de lodo (“mud volcanoes”), morfologías generadas por emisiones naturales de hidrocarburos en los fondos marinos. Asimismo, se ha establecido la relación entre emanaciones gaseosas y presencia de gas en los sedimentos del fondo marino y las estructuras profundas y someras en la región. Finalmente, se han establecido las áreas con mayores potenciales a partir de la integración de todos los resultados disponibles. Este estudio permite asegurar las potencialidades del Golfo de Guacanayabo para estudios posteriores en relación con la presencia de hidrocarburos en el subsuelo.
Estratigrafía sísmica 3D aplicada a la estimación de litología en un sistema deltaico
Authors: Illidge Erick Johan , Camargo Jorge Leonardo , Pinto-Valderrama Jorge
Published: October 2021

Seismic stratigraphy becomes a useful tool when it comes to 3D lithology distribution, since it gives the interpreter insights of the facies most likely to be present in a certain sedimentary environment. On the other hand, it is also the main input information while modeling petrophysical properties like water saturation, effective porosity and permeability, which are critical in the process of evaluation of a hydrocarbon reservoir. In this context, techniques such as seismic inversion allows the geoscientists to get 3D models of P-impedance, S-impedance and density, which are used as the main input to estimate the reservoir petrophysical properties just mentioned and additionally useful parameters used as a lithology indicator. This paper proposes a workflow to achieve the goal of integrating seismic stratigraphy, seismic inversion and attributes to get a lithology 3D model. Now, to get a suitable correlation between the facies interpreted using well logs and core data with the elastic properties, rock physic templates (RPT’s) were made where proper elastic modulus was carefully chosen to define probability distribution functions (PDF’s) for each facies defined in the correlation wells. On the other hand, based on a set of stratigraphic surfaces created on a different study, 3D models of P-impedance, S-impedance and density were obtained from seismic inversion so that the RPT’s could be built. For this specific instance, only a set of the elastic properties and seismic attributes offered a suitable correlation with the facies defined in the calibration wells. Moreover, the probability distribution functions (PDF’s) already generated allowed the distribution in 3D and the definition of the ranges in which each facies previously stated varies for the elastic modulus estimated.
Análisis complementario entre parámetros instrumentales y macrosísmicos: terremoto de mayo 24, 2008 en Quetame, Colombia
Authors: Salcedo-Hurtado Elkin de Jesús , Gómez-Capera Augusto Antonio , Mora-Páez Héctor
Published: October 2021

El terremoto ocurrido el 24 de mayo de 2008 en el municipio de Quetame (Colombia), es un evento reciente detectado por la Red Sismológica Nacional de Colombia (RSNC) y la Red Sismológica Mundial, que reportaron parámetros como: epicentro, profundidad, magnitud, momento sísmico escalar y mecanismo focal, entre otros. Basado en los daños y efectos causados, INGEOMINAS (Servicio Geológico Colombiano) evaluó el campo macrosísmico elaborando el mapa de intensidades con datos en diversas poblaciones de los departamentos de Cundinamarca, Tolima y Meta, principalmente. Tomando como base esta información macrosísmica, en el presente trabajo se aplican algunos métodos de análisis macrosísmico para obtener los correspondientes parámetros focales. Los resultados muestran fuertes correlaciones o similitudes entre los parámetros instrumentales y macrosísmicos. Instrumentalmente se reportó: Epicentro 4,4°N y 73,81°O; 5,9 Mw, 5,9 Ms, 5,6 mb, 5,7 ML; h=14,7 km, M0=7,95*1024 dinas-cm. Mientras que macrosísmicamente se obtuvo: Epicentro 4,34°N y 73,86°O; 5,94 Mw, 5,5 Ms, 5,6±0,2 mb, 5,63 ML; hn=12,1 km, hl=2,23 km; E=4,57*1020 ergios, M0=9,14*1024 dinas-cm; también se determinaron los parámetros de las dimensiones del foco sísmico y la deformación sismotectónica expresada por el flujo sísmico de la masa rocosa. Los procedimientos aplicados muestran el carácter de complementariedad entre los datos instrumentales y macrosísmicos.
Evaluación del uso de sensores remotos para identificar manchas de crudo en áreas costa afuera del Uruguay
Authors: Vasquez-Dolande Eduardo , Morales Ethel , Achkar Marcel
Published: October 2021

El uso de Sensores Remotos para la captura de datos de la superficie terrestre y marina constituye un área de investigación muy activa en los últimos 20 años. Una de las posibles aplicaciones es la detección de hidrocarburos en cuerpos de agua, bien sea con fines ambientales o para la prospección de posibles yacimientos petrolíferos. Desde el punto de vista geológico, en el margen continental uruguayo se localizan tres cuencas sedimentarias: Punta del Este, Pelotas y Oriental del Plata, las cuales presentan posibilidades de contener acumulaciones de hidrocarburos. En este trabajo se propone la utilización de la teledetección para la identificación de manchas de crudo u oil seeps en áreas marinas. Se evalúan las distintas técnicas de percepción remota para la detección de oil seeps. Mediante una revisión del estado del arte, se establece que los sensores activos satelitales de radar de apertura sintética (SAR), presentan mejor desempeño en la detección de crudo que los pasivos. Posteriormente, se define una metodología sencilla y replicable que comprende el preprocesamiento y procesamiento de las imágenes SAR junto a la implementación de un algoritmo de detección de crudo que ha sido ampliamente probado y de fácil implementación, como lo es el de Brekke y Solberg de 2005. Luego de validar la metodología en áreas piloto del Canal de Santa Bárbara y el Río de la Plata se procede a aplicarla en el área de estudio, de 20.101 km2, en el offshore uruguayo, obteniéndose 2 detecciones que suman 18,7 ha, aunque con bajo nivel de confianza debido a que las polarizaciones disponibles (HH-HV) no son las óptimas para la detección. De los resultados obtenidos se concluye que la metodología empleada es viable para detectar oil seeps en grandes superficies de cuerpos de agua con costos relativamente bajos.
Trasplante facial generalidades
Authors: Méndez Cárdenas Jefferson Gerardo , Nieto Fernández Daniela , Erazo Arteaga María Camila , Pineda López Daniel Mauricio , Quintero Cuervo Diana Yeraldín , Santamaría Losada Paola Andrea , Ruiz Moreno Carlos , Nieto Bayona Miguel Angel , Leuro-Torres Sergio Alejandro , Gómez Rueda Miguel Ángel
Published: October 2021

El trasplante facial es un alotrasplante compuesto vascularizado que busca la reconstrucción de defectos masivos faciales permitiendo la reinserción social del receptor, generando un impacto positivo sobre su calidad de vida. El objetivo de este artículo fue realizar una revisión de la literatura sobre generalidades del trasplante facial, enfocándose en los cuidados pre, intra y postoperatorios concernientes a la temática. La búsqueda bibliográfica se realizó desde el 13 de septiembre del 2018 hasta el 31 de marzo del 2019 utilizando los términos MESH “Face Transplant” y “Face Transplantation”. Aplicando los criterios de inclusión y exclusión se obtuvieron 43 artículos sobre los cuales se desarrolló la revisión. El trasplante facial es un procedimiento nuevo en el cual hay muchas áreas por explorar, sin embargo, es una alternativa prometedora a los métodos utilizados para la reconstrucción de lesiones faciales complejas, que se optimizará a medida que se extienda su uso.
Síndrome serotoninérgico como reacción adversa infrecuente ante la sinergia entre Linezolid y Fentanilo: presentación de caso
Authors: Zambrano Urbano Jose Leonel , Ocampo Chaparro José Mauricio , Lerma Flórez Eduardo , Casanova María Eugenia
Published: October 2021

El síndrome serotoninérgico es una condición potencialmente mortal causada por medicamentos que afectan el metabolismo de la serotonina o que actúan como agonistas directos del receptor de esta o una combinación de ambos. El síndrome da lugar a una variedad de manifestaciones mentales, autonómicas y neuromusculares, que pueden variar desde leves hasta potencialmente mortales. Se reporta el caso clínico de un paciente el cual desarrolló este síndrome por la coadministración y sinergismo de linezolid y fentanilo, con una gran variedad de características clínicas, desde las más sutiles, como cifras tensionales altas de difícil manejo mientras se encontraba bajo el efecto de sedoanalgesia, hasta las manifestaciones más floridas del síndrome posterior a la suspensión de esta. La asociación de estos medicamentos representa una etiología poco informada que puede favorecer la aparición del síndrome, mientras que el uso de benzodiazepinas puede enmascarar el cuadro dificultando su diagnóstico.
Estrategias de intervención en la UCI neonatal: un enfoque fisioterapéutico
Authors: López Rodríguez Laura Valentina
Published: October 2021

El fisioterapeuta a lo largo de su profesión ha ampliado el espectro de intervenciones y escenarios de desempeño, siendo uno de los más recientes el abordaje en la unidad de cuidado intensivo neonatal. Recientemente se han reportado en la literatura diferentes estrategias de intervención con el objetivo de lograr un desarrollo adecuado del neonato, tales como masaje, estimulación kinestésica, educación en el programa madre canguro, y maniobras de tórax. El objetivo del artículo fue revisar la información actual proveniente de la evidencia científica disponible sobre estas diferentes estrategias de intervención aplicadas en la unidad de cuidado intensivo neonatal, por lo que se realizó una revisión bibliográfica de los artículos encontrados entre febrero y agosto del 2019 en las bases de datos PUBMED y SCOPUS. Se obtuvieron 40 artículos que cumplieron los criterios de selección y que se incluyeron en la revisión. Finalmente, se concluye que estas estrategias de intervención fisioterapéutica contribuyen al logro de un desarrollo integral adecuado en el neonato.
Pénfigo benigno familiar de presentación atípica en paciente sin antecedente familiar
Authors: Chaustre Torres Linda Adori , Torra Barajas Oscar Leonardo , Rubiano Cesar Augusto , Gutiérrez Moreno Mario Fernando
Published: October 2021

La enfermedad de Hailey-Hailey, también llamada pénfigo familiar benigno, corresponde a una genodermatosis debilitante que se transmite mediante un patrón autosómico dominante, con una prevalencia de alrededor de 1 en 50.000 casos. El reporte de antecedentes familiares está presente hasta en 60 % de los pacientes. Se caracteriza por la presencia de vesículas crónicas y recurrentes, erosiones y exulceraciones en zonas de flexura. El tratamiento puede representar un reto, porque a pesar del manejo con terapias tópicas, corticosteroides sistémicos, inmunomoduladores sistémicos y el empleo de láser, ninguna terapia ha logrado una remisión a largo plazo. Se presenta el caso de un paciente masculino, adulto medio, sin antecedente familiar alguno, con historia de placas de superficie descamativa y hematocostras recurrentes crónicas y presentación clínica atípica, dada la localización de lesiones predominantes en miembros superiores, con sospecha inicial de psoriasis vulgar, con posterior toma de biopsia y reporte de patología que evidencia histológia típica de PBF. Por lo cual se indica manejo con corticosteroides sistémicos, sin evidencia de reacciones adversas y con remisión a largo plazo.
Presentación atípica de síndrome de CamuratiEngelmann en una paciente femenina colombiana. Reporte de caso
Authors: Ramírez Zuluaga Liliana Patricia , Ruano Restrepo Mario Iván , Osorio Bermúdez Juan David , Díaz Vallejo Jhony Alejandro
Published: October 2021

El síndrome de Camurati-Engelmann, también conocido como displasia diafisaria progresiva, es una enfermedad rara, autosómica dominante y con una prevalencia de uno por cada millón de habitantes. Genera mutaciones del factor de crecimiento transformante beta, que participa en la proliferación ósea. Son frecuentes las manifestaciones osteomusculares y neurológicas, con escasas expresiones de laboratorio. El diagnóstico se basa en la clínica, los hallazgos radiológicos y la confirmación genética; el tratamiento se dirige al control sintomático y el pronóstico es incierto. La presente publicación tiene como objetivo compartir con la comunidad médica el tercer caso de síndrome de Camurati-Engelmann conocido en Colombia. Se trata de una paciente femenina de 33 años con cuadro clínico de distonías intensas y signos y síntomas característicos de este síndrome, cuyo diagnóstico fue confirmado por prueba molecular, encontrando la presencia de la variante patogénica p.Arg156Cys en el gen TGF-β1, con presentación de novo.
Natural and recreational potential of the region: opportunities and prospects for use in the post-pandemic period
Authors:   Sochi State University, Onishchenko Elena V. , Slepchenko Vladimir A. ,   Federal Research Centre “The Subtropical Scientific Centre of the Russian Academy of Sciences”
Published: October 2021

The main content of the study is the analysis of the interpretation of the term “natural and recreational potential” in its modern understanding, given the increased role of the tourism industry in preserving and building up human potential in the post-pandemic period. The study of this problem against the background of the new Tourism and the Hospitality Industry National Project currently being developed is relevant, since it affects the key component of the natural resource base for the development of the national economy, reveals the strategic prospects for ensuring sustainable socio-economic development of the regions of the country with recreational and tourist specialization. The authors conclude that the natural recreational potential is not only the totality of the natural recreational resources of the territory in their quantitative and qualitative representation, but also the prevailing conditions for their use (subjective and objective), latent capacities that can limit or activate the development of tourist activities in the regions. The hierarchical structure of the natural and recreational potential of the region is presented, which includes, in addition to natural recreational resources, a group of factors that affect the efficiency of their use. The paper determines that access to the technological aspects of tourism industry management, using digitalization in the Big Data mode, is a key factor in ensuring the rational and effective use of natural and recreational potential in the creation of regional tourism products, to promote sustainable socio-economic development regions of Russia. In the course of the research, along with general scientific methods, systemic and structural-functional approaches, comparative and retrospective methods of analysis were used.
Peculiarities of the formation of clusters of entrepreneurship in the regions of Russia
Authors:   Ural State University of Economics, Antipin Ivan A.
Published: October 2021

The national goals and strategic objectives of the development of the Russian Feder- ation imply the dynamic growth of small and medium-sized businesses, but its cur- rent state raises certain concerns. In these conditions, it is necessary to search and analyze new forms of work, including cluster integration. The purpose of the work is to study the potential of the cluster organization of small and medium-sized busi- nesses and analyze the features of the functioning of modern business clusters in Russia. As a result, it was found that in a number of countries there are clusters that include only small and medium-sized enterprises. Such clusters can create a single value chain and compete in the global market. At the same time, even a partial mani- festation of cluster effects has a positive effect on entrepreneurial activity. To a cer- tain extent, similar trends are taking place in Russia. However, clusters of small and medium-sized enterprises in the domestic economy are poorly studied and are rarely formalized. An analysis of Russian clusters of small and medium-sized enterprises with an institutionally fixed status showed that their creation often depends on a sub- jective factor. More often this is resorted to by non-resource regions that need new points of growth. Clusters of small and medium-sized enterprises are very unevenly distributed over the territory of Russia, and this is due to the large number of ―hid- den‖ clusters. Tourism and information technology prevail among the types of eco- nomic activities. This can be explained by the ubiquitous spread of entrepreneurial structures of the corresponding profile. The period of operation of the cluster has no statistically significant relationships with the total number of employees and the av- erage number of employees per enterprise. Consequently, further in-depth studies of the problems and features of the functioning of such clusters, including unofficial ones, are required.
The Prevalence of Gestational Diabetes Mellitus in Pregnant Women Referred to Amir al-Mu'minin Hospital of Gerash City, Fars Province, Iran
Authors: Rezaee Elham , Mohammadi Fariba , Boozhmehrani Mohammad Javad , Bagheri Parisa
Published: October 2021

Background and Aims: The increasing number of pregnant women being diagnosed as having gestational diabetes mellitus (GDM) and  lead health care providers to develop reliable screening protocols and know the exact worldwide epidemiology of the disease. This study seeks to obtain data that will help to improve the epidemiologic knowledge about this disease.
Materials and Methods: This cross-sectional study was performed on 953 pregnant women seeking routine prenatal screening tests. Participants participate with using Carpenter-Coustan criteria in the study. Statistical analysis was performed using SPSS software.
Results and Conclusions: Among 953 pregnant women , 38 participants (4%) were detected to have GDM . Fifty percent of patients in the study were overweight .The data showed a significant difference in the mean age between the diabetic and non-diabetic groups. The high prevalence of GDM in young Iranian pregnant women may emphasize the need for early diagnosis and treatment to avoid adverse outcomes associated with GDM.
Seroprevalence of Human Cystic Echinococcosis in Sanandaj City, Kurdistan Province, Western Iran
Authors: Nazari Naser , Nayeri Tooran , Hazrati Farkhondeh
Published: October 2021

Background and Aims: Echinococcus granulosus (E. granulosus) is a cestode parasite that causes cystic hydatid disease in humans worldwide. Iran is one of the endemic regions for infection that indicate the importance and presence of infection in this country. Therefore, the current research aimed to characterize the seroprevalence of human cystic echinococcosis in Sanandaj city, Kurdistan province, western Iran.
Materials and methods: Totally, 500 serum samples were collected from patients referred to different health centers in Sanandaj city using cluster sampling in 2018-2019. All the sera were examined using the enzyme-linked immunosorbent assay test.
Results: The seroprevalence of human hydatidosis was reported at 2.2% by ELISA test in Sanandaj city. This rate was 9 (1.9%) in women and 2 (0.4) in men. The age group of 20-30 years old had the highest positivity rate (1.0%). Also, the subjects that consumed home slaughtered meat had the highest infection rate at 4 (0.8%). There was no significant difference regarding factors studied such as sex, education, residence, consumed water, keeping a dog, and the seropositivity.
Conclusions: Seroprevalence of human cystic echinococcosis in Sanandaj city is lower than the general prevalence in Iran. Our research team hopes to provide accurate data on the prevalence of hydatidosis in Sanandaj encourage more extensive research to help prevent this parasite in Iran and worldwide.
Effect of Thymol on the Level of Bcl-2 Family Transcript in the Hypertrophied Heart of Rats
Authors: Safari Fatemeh , Atarodi Reza , Jamshidi Hamid Reza
Published: October 2021

Background and Aims: Long-term surge of heart loads causes cell hypertrophy. Left ventricular hypertrophy is an adaptive response of the heart to pathological stimuli such as hypertension. B-cell lymphoma 2 (Bcl-2) family members play an essential role in this process regulation. This study aimed to evaluate the effect of thymol on the transcription level of Bcl-2 family factors in the rat model of left ventricular hypertrophy.
Materials and Methods: Male Wistar rats were divided into four groups: 1- Control 2-Untreated hypertrophy (H), 3 and 4 groups which received 25 and 50 mg/kg/day of thymol (H + Tym25 and H + Tym50 groups, respectively). Hypertrophy was induced by abdominal aortic banding, and the real time polymerase chain reaction technique was used for gene expression.
Results: Data showed that in the H group, the mRNA level of the BAD was increased significantly (p ˂ 0.001). However, the transcription level of BAX was increased in the H and H+Tym25 compared with the control group. In the H + Tym50 group, BAX mRNA level decreased significantly compared to the H group (p ˂ 0.05).
Conclusions: Our findings demonstrated that the expression rates of the antiapoptotic factor, Bcl-2, was significantly increased in the H group (p < 0.01) and thymol-treated hypertrophy groups (p < 0.001). Interestingly, the upregulation of Bcl-2 mRNA was statistically significant in the H+Tym50 group compared with H and H + Tym25 groups (p < 0.01). The results showed that thymol could protect heart hypertrophied by increasing the expression of anti-apoptotic factors.
Home Care Services during the COVID-19 Pandemic: Justice-Oriented Perspective
Authors: Alipour Vahid , Hamidi Hadi , Souresrafil Aghdas , Bagheri Faradonbeh Saeed , Sheikhy-Chaman Mohammadreza
Published: October 2021

During the COVID-19 pandemic, patients with better general conditions are sent to their own homes for self-quarantine due to a lack of resources in the health system, especially the lack of beds and human resources. Improving patient care may force households to inevitably use home care services, which can be examined from the health equity perspective. In the first step, home care services should be expanded by medical universities in all regions of the country, including less developed areas. In the second step, the financial protection of the recipients of these services should be provided through interventions, such as health insurance coverage. In addition, after the COVID-19 pandemic (post-corona period), it is necessary to organize home care services as soon as possible due to the population aging trend. Finally, despite the problems caused by the COVID-19 pandemic in the country, it is better to use the challenges, actions, and lessons learned from this crisis to complete the infrastructure of the health system in various ways.
Factors Affecting Hospital Network Management in the Social Security Organization of Iran
Authors: Mohammadi Farideh , Masoudi Asl Iravan , Mahfoozpour Soad , Hessam Somayeh
Published: October 2021

Background: Hospitals are considered the most important consumer units in the health system. Based on the effect of the hospital network in optimal and efficient hospital management, this study aimed to identify and explain the role of factors influencing hospital network management in the Iranian Social Security Organization (ISSO).
Methods: This study was conducted by a mixed method in 2018. First, variables and factors affecting the management of hospital networks were extracted from the literature review and through interviews with 15 experts, and a questionnaire with 40 questions was developed. Then, it was distributed among 448 experts in the healthcare section of the ISSO all over the country, and 405 questionnaires were completed and collected. Data were analyzed via exploratory and confirmatory factor analysis and structural equations using SPSS23 software and AMOS24 software. The validity of the questionnaire was determined via expert judgment (CVRs = 0.40) and reliability was estimated by Cronbach's alpha coefficient (α = 0.87).
Results: Based on the confirmatory factor analysis, financing, monitoring and evaluation, accountability, strategic planning, and decision rights were identified as key factors affecting hospital network management. Financing with standard coefficients of 0.83 had the highest and decision rights with standard coefficients of 0.44 had the lowest effect on hospital network management of the ISSO.
Conclusion: To efficient hospital network management of the ISSO, while emphasizing all identified factors, special attention should be paid to financing and modifying the method of budgeting and using suitable monitoring and evaluation mechanisms.