bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhibition of casein kinase 2 induces cell death in tyrosine kinase inhibitor resistant chronic myelogenous leukemia cells
Authors: Mitrovský Ondřej , Myslivcová Denisa , Macháčková-Lopotová Tereza , Obr Adam , Čermáková Kamila , Ransdorfová Šárka , Březinová Jana , Klamová Hana , Žáčková Markéta
Published: May 2023

Chronic myelogenous leukemia (CML) is a myeloproliferative disease characterized by the BCR-ABL oncogene. Despite the high performance of treatment with tyrosine kinase inhibitors (TKI), about 30% of patients develop resistance to the therapy. To improve the outcomes, identification of new targets of treatment is needed. Here, we explored the Casein Kinase 2 (CK2) as a potential target for CML therapy. Previously, we detected increased phosphorylation of HSP90β Serine 226 in patients non-responding to TKIs imatinib and dasatinib. This site is known to be phosphorylated by CK2, which was also linked to CML resistance to imatinib. In the present work, we established six novel imatinib- and dasatinib-resistant CML cell lines, all of which had increased CK2 activation. A CK2 inhibitor, CX-4945, induced cell death of CML cells in both parental and resistant cell lines. In some cases, CK2 inhibition also potentiated the effects of TKI on the cell metabolic activity. No effects of CK2 inhibition were observed in normal mononuclear blood cells from healthy donors and BCR-ABL negative HL60 cell line. Our data indicate that CK2 kinase supports CML cell viability even in cells with different mechanisms of resistance to TKI, and thus represents a potential target for treatment.
Factors of well-being of youth with complex medical conditions from the experience of hospitalization and convalescence: A pilot study
Authors: Muñoz-Violant Sarah , Violant-Holz Verónica , Rodríguez Manuel J.
Published: May 2023

Well-being in children with a complex medical condition (CMC) impacts the way they view and communicate with their immediate environment as well as their development, and it is thus necessary to inquire about the contextual issues and different needs that a CMC carries. This pilot study aimed to identify factors of pediatric well-being from the experience of hospitalization and convalescence of youth with CMC and their caregivers, in a cross-sectional analysis using a selective methodology complemented by an indirect observational methodology. We analyzed the quality of life and well-being of youth with CMC using a validated KINDLR questionnaire. We collected 35 surveys: 11 from youth with CMC and 24 from caregivers from Spain. We focused the analysis on sociodemographics, well-being perceptions, and coping strategies variables. The results show that children aged between 3 and 6 years and their caregivers scored physical well-being the lowest out of all dimensions of well-being, and they scored family well-being the highest. Moreover, youth between the ages of 7 and 17 years and their caregivers scored school-related well-being the lowest. Coping strategies to deal with stressful situations differ between children and caregivers. While children mainly engage in social withdrawal, caregivers engage in cognitive restructuring and expressing emotions. However, we did not find a relationship between coping strategies and well-being perceptions. These results highlight the need to facilitate communication spaces with both families and health professionals where the voice of children is considered.
Trauma as Evidence: Rifat Osman on Edirne
Authors: Sarisakal Beril
Published: May 2023

Early twentieth-century Ottoman-Turkish architectural history discourse is subjugated by state-oriented readings, and the prescriptions of the sociopolitical ideologies of the epoch. The agency of the individual is confined within the ramifications of these programmatic concepts. In lieu of such a discourse, this article considers Rifat Osman (1874–1933) and the agency of the individual as a source for architectural historiography. Trained as a medical doctor, Rifat Osman developed an interest in the architectural heritage and everyday life of the city of Edirne, now in western Turkey. He amply recorded his observations. Exploring the motives behind this unusual interest, I argue that Rifat Osman’s experience of Edirne, in particular as he witnessed the fall of the city to Bulgarians during the Balkan Wars (1912–13), transformed his engagement with the city and its history. This rendered the traumatic imprint of war traceable in his accounts. Through concepts of antiquarian sensitivity and war-induced trauma, I question how Rifat Osman’s anxiety is transmitted to the collective memory of the city, and in return, how architectural history becomes instrumental in the recovery from trauma.
The Destruction of the Old Bridge in Mostar: A Rupture in Collective Urban Space and Life
Authors: Mandić Asja
Published: May 2023

This article examines the destruction of the sixteenth-century pedestrian bridge of the city of Mostar, the Old Bridge, during the war in Bosnia and Herzegovina (1992–95) as a substantial disruption to the city’s urban fabric. The bridge was the symbol of the city, its most recognizable landmark, and a monument that linked two sides of the Neretva River into an integral urban unit. Reflecting on the repercussions of such violence in the context of the image of the city, I address the identity of the bridge, and the social relations inscribed in the materiality of the surrounding urban space. Due to the violence of the war and continued interethnic conflict, the meaning of the bridge changed; the construction of a new bridge on the same site was unable to repair breaches in the social relationships between Mostar’s communities. Architectural responses to rupture in the divided and contested city are exemplified in Mostar, an urban setting that has been ravaged by war, trauma, and ethno-nationalism.
Sobre el Imperium de Augusto una vez más. Puesta al día de una cuestión centenaria
Authors: López Gómez Helena
Published: May 2023

El presente trabajo pretende ser una nueva contribución y puesta al día sobre una interesante cuestión que ha intrigado a la historiografía durante siglos. Las incógnitas sobre la naturaleza del régimen instaurado por Augusto una vez se hizo con el poder en solitario han atraído la atención de los historiadores desde el siglo XIX (Mommsen, 1876-1888; Puchta, 1882; Kromayer, 1888; Pellham, 1888; Abele, 1891; Gardthausen, 1896; Bonfante, 1902; Betti, 1915; Dessau, 1924; Von Premerstein, 1937, y un largo etc.). Tradicionalmente se ha considerado que la posición imperial estaría constituida por una serie de elementos individuales que, en conjunto, darían unos grandes poderes a su poseedor, sin por ello crear una nueva institución como tal. Entre los principales poderes detentados por Augusto y sus sucesores se han señalado especialmente el imperium, el control de una serie de provincias y la tribunicia potestas. En este trabajo la atención se dirigirá hacia el primero de estos elementos, pues, dentro del amplio tema, un lugar central lo ocupa la definición de las características del imperium del primer princeps. La confusión en los acontecimientos que siguieron al 31 a. C. y las acciones y disposiciones de Augusto no ayudan a clarificar los hechos, siendo extremadamente complicado atribuir intervenciones imperiales a un poder concreto. Mi intención es exponer los acontecimientos que siguieron a la toma del poder en solitario explicando, a través de las distintas percepciones de los principales autores expertos sobre la materia, las interpretaciones dadas a la conformación del imperium de los príncipes. Aunque mi análisis sea profundamente historiográfico, ello no excluye que también se intente aportar una visión particular sobre el tema a tratar, lo que contribuirá a mantener vivo este tema centenario que está lejos de ser concluido.
Definiendo cronologías cerámicas y procesos de fortificación altomedievales desde el noroeste peninsular. Una aproximación desde el Castelo da Veiga (Culleredo, A Coruña)
Authors: Nión-Álvarez Samuel , Sánchez-Pardo José Carlos , Alonso Toucido Francisco , Fernández-Rodríguez Carlos , Otero Vilariño Carlos , Carneiro Alonso Alba , Silva Alvite Verónica
Published: May 2023

El presente artículo propone una aproximación al registro material del yacimiento de Castelo da Veiga (Culleredo, A Coruña), una fortificación de pequeñas dimensiones datada en el siglo X y ubicada en un emplazamiento conspicuo con gran control visual a larga distancia. El valor de su registro arqueológico radica en dos aspectos principales: en primer lugar, la (relativa) cantidad de materiales documentados, en contraposición a la habitual ausencia de evidencias materiales en el resto de los castillos roqueros excavados en el Noroeste. Este hecho permite, por primera vez, explorar las formas de ocupación de este tipo de fortificaciones con un mayor nivel de detalle. En segundo lugar, este registro cerámico proporciona una cantidad notable de formas cerámicas representativas del mundo altomedieval, con contextos fiables y dataciones radiocarbónicas rigurosas y coherentes, que permiten datar con mayor precisión algunas de las formas paradigmáticas del repertorio cerámico del norte peninsular, habitualmente identificadas bajo cronologías poco fiables o dataciones relativas. Este trabajo, por tanto, tiene como objetivo exponer una interpretación detallada del Castelo da Veiga. Se establece una secuencia cronológica fiable de su estratigrafía y su registro material, con datos relativos sobre las características del asentamiento, sus estrategias de ocupación y su configuración interna, para posteriomente contextualizarlo en el marco de las dinámicas de fortificación del paisaje altomedieval gallego. Posteriormente, se realiza una aproximación al registro material, especialmente el cerámico, aprovechando la fiabilidad del contexto arqueológico y la precisión de las dataciones para encuadrar determinadas producciones y tipologías habituales en un marco cronológico sólido, procurando proporcionar una base de estudio más sólida para futuras investigaciones.
Metodología de detección con dron (RPAS) aplicada a la prospección de arte rupestre prehistórico
Authors: Molina Hernández Francisco Javier , Barciela González Virginia , Martorell Briz Ximo
Published: May 2023

La prospección, detección y documentación de arte rupestre prehistórico en paredes, abrigos y cuevas poco profundas está, a menudo, condicionada por su accesibilidad. Las características geográficas del entorno y las transformaciones del paisaje a lo largo de milenios, tanto por causas naturales como antrópicas, son factores determinantes a tener en cuenta. El objetivo de este trabajo es contribuir a crear un marco metodológico que permita incorporar el uso de drones a la prospección arqueológica para la localización de yacimientos con arte rupestre situados en zonas de difícil acceso, partiendo de la experiencia desarrollada en el proyecto Arte rupestre y paisajes culturales en la montaña de Alicante. La observación de pinturas y grabados de forma segura sería, por tanto, la primera fase en los trabajos de prospección en estos entornos de geografía compleja, permitiendo la selección de aquellos abrigos con resultado positivo para su acceso mediante diferentes métodos tradicionales, con el objeto de realizar los pertinentes trabajos de verificación, documentación y estudio, previamente autorizados por la administración competente. Esta metodología puede aplicarse no solo en la investigación de Arte rupestre prehistórico, sino también en el contexto de los estudios de impacto patrimonial en relación con la conservación preventiva, teniendo en cuenta las diversas problemáticas que amenazan este patrimonio, tales como promociones urbanísticas, explotaciones de cantería o la práctica de actividades lúdicas y deportivas al aire libre. De igual modo, si bien este estudio se centra en las manifestaciones prehistóricas, podría ser empleado en la detección de enclaves sobre soportes similares de cualquier período histórico.
La felicidad en la Historia. Representaciones literarias de la felicidad desde la Antigüedad al presente
Authors: Aprile Guillermo
Published: May 2023

La felicidad no pertenece exclusivamente al dominio de la filosofía o de la psicología: las palabras de la felicidad son literarias, el estudio de los discursos sobre la felicidad, a través de los tiempos y los géneros, es fundamentalmente literario. El presente volumen, resultado del trabajo del proyecto de investigación «La felicidad en la Historia: de Roma a nuestros días (FELHIS)», toma a los textos de la Antigüedad clásica y a las recepciones contemporáneas de temas y textos clásicos como punto de partida para reflexionar sobre los diferentes usos y representaciones literarias de la felicidad. Siguiendo una perspectiva interdisciplinar, conviven en este libro los enfoques filológicos, de tradición y recepción clásica, y comparatistas. Presentamos este volumen como una aportación académica a los estudios de felicidad desde la perspectiva de las humanidades actuales.
MEMORI TRAUMA PERANG AMBON DALAM NOVEL KEI: KUTEMUKAN CINTA DI TENGAH PERANG KARYA ERNI ALADJAI
Authors: Hardianti Sitti
Published: May 2023

Kei: Kutemukan Cinta di Tengah Perang (2013) is a novel by Erni Aladjai that tells the dark events of the Ambon civil war 1999 that occurred in Ambon (Kei Islands). The problem in this research is how the author reconstructs the memory and trauma of war that caused psychic wounds for the survivors, and how this novel becomes the middle voice. The descriptive analysis method was used to look at the narrative as well as the text that gave rise to the construction of traumatic memory. Meanwhile, for the theory, Cathy Caruth's trauma memory theory is used. The results showed that all the traumatic events of the Ambon civil war that occurred in the Kei islands left psychological scars and traumatic memories for the survivors. This memory is narrated in bombings, massacres, and so on. The survivors were trauma, and the traumatic events were present in the symptoms of nightmares and flashbacks. Meanwhile, this novel can also become a middle voice to voice the other stories of the survivors in the public space. It was realizing that in fact the demands for truth and justice for them have never disappeared buried with the past.
Biological Control of Bacterial Grain Rot Disease Caused by Burkholderia glumae Using Actinomycetes
Authors: Nurmujahidin  , Giyanto Giyanto , Dadang
Published: May 2023

Penyakit busuk bulir bakteri merupakan penyakit penting pada tanaman padi yang disebabkan oleh bakteri Burkholderia glumae dan menyebabkan kehilangan hasil hingga 70%. Umumnya pengendalian penyakit ini dianjurkan melalui perlakuan benih menggunakan berbagai agens hayati, di antaranya aktinomiset penghasil senyawa bioaktif antibakteri. Penelitian ini bertujuan mendapatkan galur aktinomiset yang berpotensi sebagai pengendali penyakit busuk bulir bakteri yang disebabkan oleh B. glumae. Tahapan penelitian mencakup isolasi dan skrining aktinomiset yang berpotensi sebagai agens hayati terhadap B. glumae, uji fitotoksisitas aktinomiset terhadap benih padi, dan uji keefektifan aktinomiset dalam mengendalikan B. glumae pada padi fase pembibitan. Aktinomiset yang berhasil diisolasi dari tanaman padi dan rizosfer ialah sebanyak 40 isolat dan 17 di antaranya tidak berpotensi sebagai patogen terhadap tanaman maupun mamalia. Potensi penekanan galur aktinomiset berdasarkan uji antibiosis menghasilkan 7 galur aktinomiset yang mampu menekan perkembangan B. glumae dan sebanyak 5 galur memiliki zona hambatan lebih dari 2 mm, dan tidak bersifat fitotoksik terhadap tanaman padi dan memiliki kemampuan sebagai pemacu pertumbuhan. Galur aktinomiset ini berpengaruh terhadap pertumbuhan dan menekan derajat infeksi B. glumae. Aktinomiset galur ST1, ST27, dan BT23 efektif menekan penyakit busuk bulir bakteri padi pada fase pembibitan.
Evaluasi Rasionalitas Penggunaan Antihipertensi Golongan Angiotensin II Receptor Blocker (ARB) pada Pasien Penyakit Ginjal Kronis
Authors: Momuat Annastasia Gabriella Francie , Annisaa' Eva
Published: May 2023

Penyakit Ginjal Kronis (PGK) adalah abnormalitas struktur atau fungsi ginjal yang ditandai dengan nilai GFR (Glomerular Filtration Rate) < 60 mL/menit/1,73 m2 selama > 3 bulan. Salah satu faktor risiko dari PGK adalah hipertensi. Golongan antihipertensi yang direkomendasikan pada pasien PGK salah satunya adalah Angiotensin II Receptor Blocker (ARB). Hipertensi dapat memperburuk fungsi ginjal, sebaliknya penurunan fungsi ginjal dapat memperburuk hipertensi. Oleh karena itu, penting untuk mengontrol tekanan darah pasien PGK menggunakan antihipertensi dengan penggunaan yang rasional. Penelitian ini bertujuan untuk mengetahui rasionalitas penggunaan antihipertensi golongan ARB pada pasien PGK di RSUP Dr. Kariadi Semarang tahun 2020. Penelitian ini merupakan penelitian observasional deskriptif dengan pengambilan data secara retrospektif. Sampel yang diteliti adalah 80 pasien PGK yang menggunakan golongan ARB dan dipilih menggunakan metode purposive sampling. Data diperoleh dari rekam medis yang dianalisis rasionalitasnya berdasarkan kriteria tepat indikasi, tepat pasien, tepat obat, dan tepat dosis. Hasil yang diperoleh pada penelitian ini adalah 80 pasien dinyatakan tepat indikasi (100%), 80 pasien dinyatakan tepat pasien (100%), 74 pasien dinyatakan tepat obat (92,5%), dan 80 pasien dinyatakan tepat dosis (100%). Oleh karena itu, rasionalitas penggunaan antihipertensi golongan ARB berdasarkan empat kriteria tersebut sudah cukup baik, yaitu sebesar 92,5%.
Hubungan Pembelajaran Daring terhadap Keluhan Musculoskeletal Disorders (MSDs) pada Mahasiswa Keperawatan
Authors: Nursiam Putri Sallamah , Sumeru Annas , Alvian Galih Noor
Published: May 2023

Introduction: The implementation of online learning cannot be separated from the use of electronic devices (mobile phones, tablets or laptops) and internet connections. The duration and position of the student body during online learning are often not ergonomic, so there is a risk of Musculoskeletal Disorders (MSDs) complaints.The study to measure the effect of online learning to MSDs’ complaints yet performed, specifically in nursing. This study aims to analyze the relationship between the duration and body position of using a laptop/smartphone during online learning at Nursing Department in Unsoed. Methods: This research is a quantitative research with a cross sectional design. Subject was selected by using probability sampling technique with stratified random sampling of 129 respondents. The instrument used was a questionnaire on body position using a laptop, body position using a smartphone, and perceived MSDs complaints which were modifications of a similar research. Data was analyzed by somers’d test.Results: The results found there are significant relation between the duration of using a laptop/smartphone during online learning to MSDs complaints (p=0,001), body position using laptop during online learning to MSDs complaints (p=0,000), and body position using smartphone when online learning to MSDs complaints. (p=0,005).Discussion: There are significant relation between duration, body position using laptops, body position using smartphones with MSDs complaints at Nursing Department in Unsoed.
Pengaruh Edukasi 1000 Hari Pertama Kehidupan (HPK) Terhadap Pengetahuan Dan Sikap Wanita Usia Subur (WUS)
Authors: Hidayati Diah Ulfa , Yulastini Fitria , Fajriani Evalina
Published: May 2023

Introduction: Indonesia's health development still facing various challenges, one of which is the high incidence of stunting in children under five. Based on a preliminary study conducted in Perina Village, Jonggat District, Central Lombok Regency, mothers' knowledge and attitudes about caring for the first 1000 days of life (HPK) were still low. The low knowledge and attitude of mothers about nutrition in 1000 HPK can lead malnutrition conditions that occur since in the womb and early period after birth so it can affect growth and development problems in the future. The government has promoted the "1000 HPK Movement" as an effort to improve nutrition, but the problem of nutrition in society has not been optimally resolved. To support the government's program, it is necessary to conduct education as an effort to increase mothers' knowledge and attitudes about 1000 HPK.Methods: This research is a pre-experimental study with one group pretest-posttest design. This research was conducted in Perina Village, Jonggat District, Central Lombok Regency in August 2022. The population in this study were all women of childbearing age (WUS) who live in Perina Village. The sample in this study were 30 respondents who were taken by purposive sampling technique with predetermined inclusion and exclusion criteria. The independent variable in this study was the education of 1000 HPK and the dependent variable was the knowledge and attitudes of WUS. The 1000 HPK education was carried out using the discourse method with leaflets as media. Pretest and posttest with questionnaires were given before and after education to measure the level of knowledge and attitudes of WUS about 1000 HPK. Data analysis used the Wilcoxon test in the SPSS 23 program.Results: There are differences in WUS knowledge and attitudes before and after treatment. From the results of the Wilcoxon test, the value of p = 0.000 was obtained for the knowledge variable and p = 0.001 for the attitude variable.Conclusion: There is an effect of education on WUS knowledge and attitudes about 1000 HPK. Education about 1000 HPK must be carried out regularly with a variety media to increase people's knowledge and attitudes as an effort to prevent stunting and other nutritional problems.Keywords: 1000 HPK, Education, Women of Childbearing Age (WUS).
GLUE VALUE AT RISK UNTUK MENGUKUR RISIKO PADA PORTOFOLIO OPTIMAL DENGAN METODE MULTI INDEX MODEL
Authors: Khofifah Nur , Rusgiyono Agus , Maruddani Di Asih I
Published: May 2023

Creating a portfolio is one method of reducing risk. One of the best portfolio decisions is made by Multi Index Model. Multi Index Model is a method that makes use of multiple variables that impact stock returns. Before making an investment, risk measurement must be considered. Calculation of risk on a portfolio will be more accurate if it is calculated using Glue Value at Risk, because it satisfies the property of subadditivity, which is one of the coherence properties of a risk measure that reflects the idea that risk can reduce by diversification. The stocks used in this study are 4 stocks that are members of SRI-KEHATI stock group in the period January 2017 – December 2021. The factors used are Composite Stock Price Index (JCI), and Rupiah to USD exchange rate. According to the study's findings, the best portfolio consist of four stocks: BBRI (Bank Rakyat Indonesia Tbk.) (17.82%), KLBF (Kalbe Farma Tbk.) (56.66%), UNTR (United Tractors Tbk.) (24.13%), and WIKA (Wijaya Karya Tbk.) (1.39%). The confidence levels of  and , the distortion function height is  and  are used, the GlueVaR value for the stock portfolio is 10.476%.
PERBANDINGAN MODEL ARIMA DENGAN MODEL NONPARAMETRIK POLINOMIAL LOKAL DAN SPLINE TRUNCATED UNTUK PERAMALAN HARGA MINYAK MENTAH WEST TEXAS INTERMEDIATE (WTI) DILENGKAPI GUI R
Authors: Gusman Salsabila Rizkia , Suparti Suparti , Rusgiyono Agus
Published: May 2023

Crude oil as one of the most important natural resources experiences price fluctuations from time to time, even the spot price of West Texas Intermediate (WTI) world crude oil on 20th April 2020 reached -36,98 USD/barrel due to the Covid-19 pandemic. WTI oil price data was modeled using the ARIMA method, local polynomial, and spline truncated nonparametric regression then compared and obtained the best model and formed R Graphical User Interface (GUI). The ARIMA model and nonparametric time series models can be used to model time series data, but in the ARIMA model there are assumptions that must be fulfilled. Nonparametric time series models, which include local polynomial model and truncated spline do not need to fulfill these assumptions. The ARIMA model obtained did not fulfilled the assumptions of normality and residual homoscedasticity, so the modeling was stopped and modeling was only carried out using nonparametric regression methods. Based on the minimum MSE criteria, the best nonparametric model was obtained, namely nonparametric truncated spline model with degrees 3 and 3 knot points which was categorized as a strong model based on R-squared in sample value and having a very good forecasting ability based on MAPE out sample value.
ANALISIS INDEKS HARGA SAHAM GABUNGAN DAN FAKTOR PENGARUHNYA MENGGUNAKAN PEMODELAN REGRESI SEMIPARAMETRIK KERNEL DILENGKAPI GUI-R
Authors: Kahar Arnisa Melani , Suparti Suparti , Hakim Arief Rachman
Published: May 2023

Composite Stock Price Index (IDX) shows the movement of stock prices used by investors to determine their investment strategy. IDX movement is influenced by macroeconomic factors such as money supply and inflation, so regression analysis is used to determine the relationship between the variables. Based on the scatterplot, money supply is known as a parametric predictor variable as it has a linier line patterned scatterplot and inflation is a nonparametric predictor variable as it has a random patterned scatterplot, so semiparametric regression modelling is used for the analysis. Kernel regression was chosen to analyze the nonparametric component based on the random patterned scatterplot of inflation. This study aims to obtain the results of semiparametric kernel regression modelling analysis and to create a GUI to be applied to the analysis as a development of previous similar studies that still done based on CLI. This study uses monthly data from January 2013 to December 2020 with the proportion of in sample and out sample data distribution 87,5%:12,5%. Based on the smallest MSE value as the best model criteria, semiparametric regression model with triangle kernel function is the best model obtained with optimal bandwidth=3.24,  which means the model is strong and  which means that the forecasting results are very accurate. GUI has been created according to the needs of the modelling analysis implementation.
PENGUKURAN NILAI RISIKO PORTOFOLIO SAHAM PADA INDEKS LQ45 DI BIDANG TELEKOMUNIKASI MENGUNAKAN METODE KOPULA CLAYTON
Authors: Binsanno Salsabila Syifa , Sudarno Sudarno , Maruddani Di Asih I
Published: May 2023

The characteristic of copula is non strict on certain distribution assumptions, can explain nonlinier relationship, and easily construct distribution through the marginals that do not need to come from the same distribution family. Copula will be useful for stock data that has price charts fluctuate rapidly and risk will always follow in investing. The relation between risk and copula in this study is to calculate the risk value in the stock portfolio using VaR with the generation of Monte Carlo simulation through Clayton copula on four companies engaged in telecommunications sector, namely EXCL.JK (PT XL Axiata Tbk), TLKM.JK (PT Telekomunikasi Indonesia Tbk), TOWR.JK (PT Sarana Menara Nusantara Tbk), and TBIG.JK (PT Tower Bersama Infrastructure Tbk) for period 2 January 2020 to 31 December 2021. This study resulted that the selected stock portfolios are EXCL and TBIG which had the highest risk value of -0,062741 at 99% confidence level, so when an investor will invest Rp100.000.000,00 the maximum estimated risk is Rp.6.274.100 within one day.
Pemanfaatan Pelayanan Puskesmas oleh Masyarakat di Daerah Perbatasan Kecamatan Entikong
Authors: Widiyastuty Feny , Suryawati Chriswardani , Arso Septo Pawelas
Published: May 2023

Daerah perbatasan di Indonesia termasuk ke dalam wilayah terpencil dan terisolir dengan kondisi geografis yang ekstrim dan infrastruktur yang minim. Keberadaan puskesmas juga belum dimanfaatkan dengan baik oleh masyarakat di daerah perbatasan. Puskesmas Entikong merupakan puskesmas yang terletak di daerah perbatasan memiliki capaian pelayanan rawat jalan rata-rata pertahun hanya sebesar 46,1% dan rawat inap 11%. Penelitian ini bertujuan menganalisis faktor yang berhubungan dengan pemanfaatan pelayanan kesehatan di Puskesmas Entikong Kabupaten Sanggau. Penelitian ini merupakan penelitian kuantitatif dengan desain studi cross sectional. Jumlah responden sebanyak 250 KK dipilih menggunakan tekhnik proporsional random sampling. Hasil penelitian diperoleh nilai signifikansi dari masing-masing variabel yaitu kebutuhan (preceived need) (p=0,000), asuransi kesehatan (p=0,033), jarak tempuh (p=0,423), waktu tempuh (p=0,221), budaya (p=0,000), persepsi sakit (p=0,018), dan persepsi pelayanan kesehatan (p=0,309). Faktor yang berhubungan dengan pemanfaatan pelayanan kesehatan adalah kebutuhan (preceived need), asuransi kesehatan, budaya dan persepsi sakit. Faktor yang tidak berhubungan dengan pemanfaatan pelayanan kesehatan adalah jarak tempuh, waktu tempuh dan persepsi pelayanan kesehatan. Pemberian informasi tentang kesehatan kepada masyarakat, peningkatan kualitas pelayanan, memenuhi sarana prasarana Pustu/Polindes, mendekatkan askes pelayanan serta meningkatkan cakupan kepemilikan asuransi kesehatan di harapkan dapat meningkatkan minat masyarakat dalam memanfaatkan pelayanan di Puskesmas Entikong.
The Effect of Job Security and Burnout on Turnover Intention Mediated by Job Satisfaction
Authors: Ernes Chelsia , Meilani Yohana F Cahya Palupi
Published: May 2023

The high rate of turnover among healthcare workers has become a big challenge, particularly during the COVID-19 pandemic. Therefore, understanding the factors associated with turnover intention is important. The objective of this study is to analyse the effect of job security, burnout, and their impact on turnover intention mediated by job satisfaction in healthcare workers. This study is a quantitative survey with a cross-sectional approach and 155 respondents of healthcare workers who worked in a private hospital in Batam during the COVID-19 pandemic were taken as the sample using a purposive sampling method. Online questionnaires were distributed in order to collect the data. PLS-SEM analysis method is used to analyse the data. The findings from this study are job security has a positive and significant effect on job satisfaction, burnout has a negative and significant effect on job satisfaction, job satisfaction has a negative and significant effect on turnover intention, and job satisfaction is proved as a significant mediator towards turnover intention. This finding has implications for hospital managers to make recommendations that will enable the hospital to retain more health workers and thus reduce the turnover rate.Keywords: Job security, Burnout, Job satisfaction, Turnover intention
Balzac et les géographes : reconversion d’un discours scientifique
Authors: Huaulmé Killian
Published: May 2023

The paper is an attempt at showing how the mentions and quotations of contemporary geographic discourses inserted in the Balzacian texts and paratexts are there to outline the features of a new novelistic æsthetic. We will start from the following observation: the Balzacian novel and its encyclopedic ambition are contemporaneous with the first attempts of some geographers to found a unified science from a diversified set of knowledges and practices. Therefore, modern geography may appear as an adversary of Balzac’s own ambition of totalization and we will show that geographic discourse, rather than being a model for him as other scientific discourses are, is distorted in his novels, deprived of its epistemological value and reduced to a science without knowledge.
Aristotle’s Logic of Biological Diversity
Authors: Carbone Andrea Libero
Published: May 2023

Aristotle’s biology is based on his method of division of animal kinds by multiple differentiae. This results in complex clusters of non-subordinate terms, between which Aristotle seeks to establish universal correlations. The form of these, however, does not correspond to that prescribed by his theory of syllogism. Mereological relations between terms are not linear and quantification is far more complex than the distinction between universal and particular propositions. Thus the axiomatisation of Aristotle’s biology requires a tool designed for analysing such complex universal correlations into valid syllogistic premises. Prosleptic-like premises turn out to be the solution outlined by Aristotle. They make it possible to handle both the logic of consequence which translates from and into mereological relations between term clusters, and the complex quantification required by division based on multiple differentiæ, through the instantiation of a variable ideally consisting of indivisible groups of animals.
Large-scale green hydrogen production using alkaline water electrolysis based on seasonal solar radiation
Authors: Hassan Qusay , Sameen Aws Zuhair , Salman Hayder M. , Jaszczur Marek
Published: May 2023

The research study provides a techno-economic analysis for the green hydrogen generation based solar radiation data for both the single and hybrid alkaline water electrolyzer and energy storage system systems. In addition, a carbon footprint study is conducted to estimate the developed system carbon dioxide emissions. The optimal size of the alkaline water electrolyzer and energy storage system is determined by a genetic algorithm that takes into account a carbon tax on carbon emissions. Based on itemized cost estimating findings, unit hydrogen production costs for a single system and a hybrid system were $6.88/kg and $8.32/kg respectively. Furthermore, capital cost it has been found as a key element in determining the optimal scale of the alkaline water electrolyzer and energy storage system, which are essential for minimizing the unit hydrogen production cost. Lastly, an effort to minimize the capital cost of producing green hydrogen is required when the rising trend of the carbon dioxide tax is taken into account.
An RRAM-based building block for reprogrammable non-uniform sampling ADCs
Authors: Vishwakarma Abhinav , Fritscher Markus , Hagelauer Amelie , Reichenbach Marc
Published: May 2023

RRAM devices have recently seen wide-spread adoption into applications such as neural networks and storage elements since their inherent non-volatility and multi-bit-capability renders them a possible candidate for mitigating the von-Neumann bottleneck. Researchers often face difficulties when developing edge devices, since dealing with sensors detecting parameters such as humidity or temperature often requires large and power-consuming ADCs. We propose a possible mitigation, namely using a RRAM device in combination with a comparator circuit to form a basic block for threshold detection. This can be expanded towards programmable non-uniform sampling ADCs, significantly reducing both area and power consumption since significantly smaller bit-resolutions are required. We demonstrate how a comparator circuit designed in 130 nm technology can be reprogrammed by programming the incorporated RRAM device. Our proposed building block consumes 83 µW.
Sequential positions and interactional functions of negative epistemic constructions in Japanese conversation
Authors: Endo Tomoko
Published: May 2023

In this study, we adopted the methodology of conversation analysis and interactional linguistics to investigate the use of shiranai and wakannai ‘I don’t know’ in data from (the Corpus of Everyday Japanese Conversation), a corpus of naturally occurring conversations. The quantitative and qualitative analyses of the sequential positions and the interactional functions of these two expressions revealed that shiranai is often used as a response to a question that explicitly requests knowledge status. Shiranai is also used in response to informing, soliciting more talk from the interlocutor. On the other hand, wakannai is more often used as a response to a question that requests information. Used with prosodic features such as elongation and laughter, both shiranai and wakannai sometimes convey the speaker’s affective stance towards the lack of knowledge. Furthermore, wakannai can be used as a discourse marker to mark the speaker’s low degree of commitment, sometimes working as a sequence-closing device.
Kedo-ending turn format as a formula for a problem statement with a deontic implication
Authors: Yokomori Daisuke
Published: May 2023

In many languages, some turn formats are highly fixed and closely associated with specific interactional contexts, and thus function as formulas for particular actions. In Japanese, one of the recurring turn formats for referring to a problem found in the surrounding situation or other’s conduct is a clause ending with the contrastive particlekedo‘but’. Based on close examination of examples from naturally-occurring conversations using the analytic framework of Interactional Linguistics, this article illustrates that the format withkedois used to assign a deontic authority concerning an observed problem to the recipient and thereby leaving to the recipient a decision about how the problem should be dealt with and by whom. This shows a clear contrast with the turn format ending withyo, which is used to inform the recipients of what the speaker knows as a problem, and thereby to ask the hearers to register it.
Formulaicity of fictional quotativega ittetaand its functions in Japanese social media posts
Authors: Tsuchiya Tomoyuki
Published: May 2023

Relatively longer formulaic sequences are often subject to syntactic, lexical, and semantic variability, and this variability presumably connects to the development of constructional schemata and to language creativity. The present paper focuses on the formulaicity, variation, and communicative effects of the quotative phraseX ga itteta‘X was saying’ in Japanese social media posts, whose situation would become fictional or less factual depending on the nature of the subjectX. Twitter data suggest thatX ga ittetawith certain subjects (e.g., high school girls, cats, moms; see below) is more conventionalized compared to the counterpartY-tte itteta‘was saying that Y’, where Y is a quoted statement, with the same subject. Additionally, the construction accepts variation of surrounding elements to raise its fictional level. In Japanese online platforms, the schemaX ga ittetaand its formulaic instances possibly distance the quoter from the quoted statement and avoid arguments and criticisms.
Commas as a constructional resource: the use of a comma in a formulaic expression in Japanese social media texts
Authors: Horiuchi Fumino , Nakayama Toshihide
Published: May 2023

This paper examines the use of punctuation in Japanese in order to investigate its role in formulaic expressions. Specifically, we will study the use of a comma before the copula complexdakedoneat the end of an utterance. Typically, punctuation is considered a matter of style in written representations and is generally not included in studies about the structure of formulaic expressions. However, in a corpus-based study on language use on social media (e.g., blogs, Twitter, online forums), we found that this comma is frequently used for a distinct pragmatic effect. The patterns of use, both structural and functional, are observed to be regular and predictable, enough to suggest that the comma is part of a fixed formal complex that has a unique meaning, i.e., a construction. This in turn suggests that commas, even though they are punctuation, can be a formal resource that constitutes part of a formulaic expression.
Gluconic acid: strategies for microbial production using organic waste and applications
Authors: Raj Mayank , Singh Manoj , Kumar Vikas , Devi Tamanna , Upadhyay Sushil Kumar , Mishra Prabhakar , Kumar Sunil , Yadav Mukesh , Sehrawat Nirmala , Kumari Mamta
Published: May 2023

Gluconic acid is one of the most important natural acids which are moderately generated from glucose via a straightforward oxidation reaction process. Through the use of microorganisms like Gluconobacter (bacteria) and fungi, the reaction is facilitated through various enzymes such enzyme glucose oxidase and glucose dehydrogenase. The typical widespread, fermentation procedure is characterized by the use of Aspergillus niger (fungi). The primary gluconic acid derivatives, such as sodium gluconate, are widely used in the agricultural and food industries. Gluconic acid has several uses in the pharmaceutical, food, beverage, textile, cement, metal chelating agent, leather, and dairy sectors. Commercial production of gluconic acid made by fungi is well-established. Therefore, fermentation procedures and effective microorganisms are employed to produce gluconic acid with a higher yield and higher quality. These processes are also more economical and effectively convert inexpensive substrates into carbon sources. Production of gluconic acid has been reported with corn starch, grapes must, banana must, egg shells, and potato pulp using both solid state and submerged fermentation. This article provides a thorough analytical analysis for the gluconic acid production through microbial fermentation and its uses in agriculture and food. Additionally, this contemporary paper thoroughly examines the literature from recent years on the growth of gluconic acid production for the global market.
10 hónap – 10 kihívás. Egy városi szintű integrált turisztikai szolgáltatásfejlesztési modell a gyakorlatban
Authors:   Innotime Hungary Kft., Adriány Csenge , Halmos György ,   Veszprém-Balaton 2023 Zrt., Horváth Viktória ,   Innotime Hungary Kft., Kanizsai-Nagy Dóra ,   Veszprém-Balaton 2023 Zrt., Kedves Csaba ,   Innotime Hungary Kft., Nagy Júlia ,   Innotime Hungary Kft., Sigmond Eszter ,   Pannon Egyetem
Published: May 2023

In the autumn of 2021, Veszprém-Balaton 2023 Zrt. commissioned a complex tourism audit focusing on Veszprém, the aim of which was to examine the destination offer and the operation of the individual institutions, and to identify the shortcomings that should be addressed before the European Capital of Culture year in order to ensure that guests visiting Veszprém are as satisfied as possible with the city’s tourism offer. Building on the results of the audit, a 10 months – 10 challenges programme was developed to address the problems identified during the audit on the basis of a common set of criteria. The programme provided an opportunity to make Veszprém the first Hungarian city where all tourist facilities have their own sustainability and accessibility programme, coordinated at city level, and to develop a complex destination management system supported by digital platforms, in line with the challenges of today’s world, which will contribute to the city’s long-term work for sustainable tourism and to the development and marketing of complex tourism products at city level.
Túl a városhatárokon? – Egyetemi közösségek kulturális fogyasztásának időbeli és térbeli vetületei a Veszprém-Balaton 2023 Európa Kulturális Fővárosa projekt tükrében
Authors:   Pannon Egyetem Gazdaságtudományi Kar Turizmus Intézeti Tanszék, Madarász Eszter , Raffay-Danyi Ágnes ,   Pannon Egyetem Gazdaságtudományi Kar Turizmus Intézeti Tanszék, Sulyok Judit ,   Pannon Egyetem Gazdaságtudományi Kar Balatoni Turisztikai Kutatóintézet
Published: May 2023

The cultural elements of leisure activities have a high importance in each settlement’s supply, and have numerous positive effects on the consumers, this way contributing to higher quality of life. Like tourism mobility, cultural consumption can also be understood in time and space, temporal and spatial imbalance of the demand is observed. The consumption linked to the cultural activities of local communities has a fundamental role in the operation of touristic service providers. This study addresses the cultural consumption of the community of the University of Pannonia. The questionnaire-based survey conducted among both students and employees, identifies the temporal and spatial patterns of the cultural consumption including theatre, cinema, museum, exhibition, concert and festival visits. The spatial distribution of the consumption is primarily significant in Veszprém and its surrounding area, besides that the attractiveness of Budapest is also outlined. In the case of the temporal distribution, the results of this study shed light on the fact that the usage of other services linked to the cultural activities strengthens the off-season traffic for the service providers.
The genesis of staff-student partnerships: Institutional influences
Authors: Smith Susan , Axson Dan
Published: May 2023

As staff-student partnership activity becomes embedded into the infrastructure of higher education there is an increased institutional focus on systematising the staff-student partnership support processes. Drawing on data from a case study of a partnership conceived under the auspices of an institutional staff-student partnership programme, this article offers insight into how the institutional context shapes partnership aims, objectives, and composition. It finds that in the pre-partnership phase a gatekeeping role is performed by the institutional programme, which ultimately determines which partnerships proceed, and how they are evaluated. The study contributes to the broader critique of staff-student partnership practices, proposing a framework that integrates the various institutional influences and the pre and post-partnership phases.
On the Temporal Nature of Parental Burnout: Development of an Experience Sampling Methodology (ESM) Tool to Assess Parental Burnout and Its Related Ever-Changing Family Context
Authors: Blanchard M. Annelise , Revol Jordan , Hoebeke Yorgo , Roskam Isabelle , Mikolajczak Moïra , Heeren Alexandre
Published: May 2023

Parental burnout is a growing subject of research, but thus far this research has not examined whether the features of parental burnout fluctuate over time. Moreover, parenting and parental burnout are inextricable from their family context. Therefore, a critical next step involves examining how parental burnout features temporally unfold and interact with the ever-changing family environment. To do so, we developed an 11-item experience sampling methodology (ESM) tool to measure self-reported parental burnout features (specifically emotional exhaustion, emotional distance, and feeling fed up), as well as partner relationship, children’s behavior, behavior toward children, social support, and perceived resources. We conducted two two-week periods of ESM data collection (one with French-language ESM items; n = 9; one with English-language ESM items; n=23) and one eight-week data collection with the French-language ESM items (n=50). We collected the ESM data using formr, an open-source platform, and we provide open access to all materials (including a formr template, allowing free use of the assessment tool), analysis code, and data: https://osf.io/s2yv5/. Participants’ responses indicated sufficient within-person variability (assessed via intraclass correlation) and support for convergent and discriminant validity (assessed by correlating aggregated ESM responses with retrospective questionnaire scores on parental burnout, depression, anxiety, and stress). Lastly, we found that the three parental burnout ESM items had high between-subject reliability and moderate within-subject reliability. Participating parents found the ESM survey easy to answer and not burdensome. Finally, we discuss how assessing parental burnout over time can help usher parental burnout research and treatment forward.