bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishment of Fluorescence Sensitization Method for Hydroxysafflor Yellow A
Authors: Haiyan CAO , Xiude QIN , Chen LIU , Xinzhe ZHAO , Yuhui MA , Jingna ZHOU , Yu LIU , Shaoqin GE , Guowei ZHANG , Hailiang NIE
Published: April 2020

As the main active ingredient in Chinese medicine safflower, hydroxysafflor yellow A (HSYA) has multiple pharmacological effects. In the work, the absorption and fluorescence spectra of HSYA under different environmental conditions (such as acidity, temperature, ions, viscosity, and surfactant) were investigated. The fluorescence intensity of HSYA varied greatly with acidity, temperature, viscosity, and surfactant, but was less affected by common cations and anions. Among various surfactants, we found that borax can significantly enhance the HSYA fluorescence intensity, and thus, a borax‐HSYA sensitization system for HSYA fluorescence was established. In the optimized sensitization system, the fluorescence intensity of HSYA increased by 20 times and showed a good linearity with HSYA concentrations in the range of 0∼10 μM with a detection limit of 8 nM. The borax‐HSYA sensitization system is nontoxic to T24 cells and mice and can be used for the fluorescence imaging of HSYA in cells, thereby providing an effective method for analyzing HSYA in vitro and monitoring its metabolism in cells.
Moving Vehicle Detection and Tracking Based on Optical Flow Method and Immune Particle Filter under Complex Transportation Environments
Authors: Sun Wei , Sun Min , Zhang Xiaorui , Li Mian
Published: April 2020

Video-based moving vehicle detection and tracking is an important prerequisite for vehicle counting under complex transportation environments. However, in the complex natural scene, the conventional optical flow method cannot accurately detect the boundary of the moving vehicle due to the generation of the shadow. In addition, traditional vehicle tracking algorithms are often occluded by trees, buildings, etc., and particle filters are also susceptible to particle degradation. To solve this problem, this paper proposes a kind of moving vehicle detection and tracking based on the optical flow method and immune particle filter algorithm. The proposed method firstly uses the optical flow method to roughly detect the moving vehicle and then uses the shadow detection algorithm based on the HSV color space to mark the shadow position after threshold segmentation and further combines the region-labeling algorithm to realize the shadow removal and accurately detect the moving vehicle. Improved affinity calculation and mutation function of antibody are proposed to make the particle filter algorithm have certain adaptivity and robustness to scene interference. Experiments are carried out in complex traffic scenes with shadow and occlusion interference. The experimental results show that the proposed algorithm can well solve the interference of shadow and occlusion and realize accurate detection and robust tracking of moving vehicles under complex transportation environments, which has the potentiality to be processed on a cloud computing platform.
Cooperative Innovation Behavior Based on Big Data
Authors: Ji Guojun , Yu Muhong , Tan Kim Hua
Published: April 2020

With the rapid change in technology, cooperative innovation based on data sharing has become an imminent tactic for enterprises to gain competitive advantages. This paper adopted a mixed method approach (case study-modelling-case study) to study firms’ co-opetition behavior based on their data analytics capabilities for innovation. We show that firms favor cooperation among peers with same capabilities, i.e., when each firm’s data level is comparable to their partners. We further establish that data transferability and incentive have high impact on cooperation decisions. Finally, we explain the evolution path of firms’ cooperation decisions and discuss the best options for them to sustain long-term growth and competitiveness. The results provide a basis for firms to decide how best to utilize big data for collaborative innovation, so as to improve customers’ product adoption and reduce costs.
Dynamical Properties of a Herbivore-Plankton Impulsive Semidynamic System with Eating Behavior
Authors: Wang Yufei , Cheng Huidong , Li Qingjian
Published: April 2020

In this paper, an impulsive semidynamic system of the relationship between plankton and herbivore is established, and the Poincaré map method is used to extend the new properties of the model. We define the Poincaré map of the impulsive point series in phase concentration and analyze the characteristics. A comprehensive and detailed analysis of the periodic solution is performed. In addition, the numerical simulations illustrate the correctness of our arguments. The results show that plankton and herbivore can survive stably under effective control.
The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan
Authors: Hung Chih-Chiang , Yang Youngsen , Tsai I-Chen , Hsu Chiann-yi , Liu Chia-Hua , Yang Jie-Ru
Published: April 2020

Breast cancer is a global issue regarding women’s health, and high incident rates remain in the Taiwanese female population. Chemotherapy, using anthracycline-based chemotherapeutic agents in neoadjuvant settings, has been introduced as a promising new therapeutic option for treatment of invasive breast cancer. Set apart from conventional anthracycline regimens such as epirubicin, pegylated liposomal doxorubicin (Lipo-Dox®, PLD) was introduced for providing a justifiable treatment effect, while offering a favorable toxicity profile for breast cancer patients in a metastatic setting. However, the efficacy of PLD in neoadjuvant settings for breast cancer patients has not yet been sufficiently reported. This study aims to investigate the efficacy of PLD-based neoadjuvant chemotherapy in breast cancer patients using a retrospective matched case-control study. A total of 183 PLD cases and 183 epirubicin-based controls were included after a 1 : 1 ratio case-control matching procedure was held, according to the matching criteria. These criteria included the patient’s preoperative clinical stage, molecular subtype, chemotherapy regimen with taxanes prior to surgery, and histological grade. All data were collected according to an institutional review board approved protocol. The study results reported that the PLD and epirubicin groups both obtained similar outcomes in pathologic complete response (pCR), recurrence, and overall survival rate with no statistically significant differences. Overall, the study results demonstrate that PLD-based neoadjuvant chemotherapy offers a similar effect of treatment with a favorable toxicity profile within the study follow-up duration, when compared with conventional epirubicin-based neoadjuvant chemotherapy.
Mathematical Optimization Method of Low-Impact Development Layout in the Sponge City
Authors: Men Hong , Lu Hao , Jiang Wenjuan , Xu Duo
Published: April 2020

Aiming at the optimization layout of distributed low-impact development (LID) practices in the sponge city, a new mathematical method combining Stormwater Management Model (SWMM) and preference-inspired co-evolutionary algorithm using goal vectors (PICEA-g) was developed and was applied in the Ximen waterlogged area of Pingxiang City. Firstly, a block-scaled rainfall-runoff model was built in the study area by using SWMM. Then, an LIDs area optimization model was established by linking the SWMM and the PICEA-g based on the Matlab platform, which took the area ratios of various LIDs in each block as decision variables and took the total runoff, peak flow, suspended substance (SS) pollutant, and LIDs cost as objective functions. Thus, the problem of LIDs layout was turned into a mathematical optimization issue. So the cost-benefit optimal solutions with different emphases were found by using this algorithm, and the LIDs layout optimal scheme for this area was further analysed and verified by rainfall-runoff model. The results show that the total runoff reduction rates of the system reach a maximum of 21.8%, the peak flow reduction rates of the system are more than 10%, and the SS pollutant reduction rates are reduced by about 30% compared with before LIDs under the design storms of different return periods. The reduction rates of each runoff index are higher than the nondominated sorting genetic algorithm II (NSGA-II) method, and decision-makers can more effectively analyse the cost-benefit optimal solution from the Pareto solution sets. Therefore, the LIDs layout optimization method proposed in this paper has obvious advantages in solving similar many-objective optimization problems (MOOPs) in sponge city construction.
Menstrual Hygiene Management and School Absenteeism among Adolescents in Ghana: Results from a School-Based Cross-Sectional Study in a Rural Community
Authors: Mohammed Shamsudeen , Larsen-Reindorf Roderick Emil , Awal Issahaku
Published: April 2020

The study aimed to deepen our understanding of the menstrual hygiene management (MHM) of adolescents and the influence of menstruation on school absenteeism. We employed a school-based cross-sectional design in five Junior High Schools combining both quantitative and qualitative data collection methods. A questionnaire was used to collect quantitative data from 250 schoolgirls, and key informant interviews were conducted with a teacher in each of the five schools. We performed logistic regression analysis to provide crude and adjusted effect estimates and 95% confidence intervals. About fifty percent of the girls were engaged in good MHM, and approximately forty percent of them reported menstrual-related school absenteeism. We did not find evidence (p=0.858) of association between MHM and menstrual-related school absenteeism. However, after controlling for the effect of other factors, we found evidence that the age of the schoolgirls, their father’s occupation, and the receipt of allowance for menstrual care products were associated with MHM. When compared to those aged 17 to 19, those aged 10 to 13 years had 0.72 (95% CI 0.21, 2.44) decreased odds of poor MHM while those aged 14 to 16 had almost 3-fold increased odds (95% CI 1.49, 4.55) of poor MHM. The adolescents whose fathers were farmers had 0.42 (95% CI 0.21, 0.82) decreased odds of poor MHM while those whose fathers were unemployed had 0.24 (95% CI 0.10, 0.61) decreased odds of poor MHM. We found that girls who did not receive regular allowance for menstrual care products had nearly 2-fold increased odds (95% CI 1.06, 3.09) of poor MHM compared to those who received allowance for menstrual care products. Menstrual pain (82.2%), fear of staining clothing (70.3%), fear of being teased (70.3%), nonavailability of sanitary pad (63.4%), and lack of private place to manage period at school (60.4%) were the common reasons cited for menstrual-related school absenteeism.
Additive Eigenvalue Problems of the Laplace Operator with the Prescribed Contact Angle Boundary Condition
Authors: Li Hongmei , Wang Peihe
Published: April 2020

Additive eigenvalue problem appears in ergodic optimal control or the homogenization of Hamilton–Jacobi equations. It has wide applications in several fields including computer science and then attracts the attention. In this paper, we consider the Poisson equations with the prescribed contact angle boundary condition and finally derive the existence and the uniqueness of the solution to the additive problem of the Laplace operator with the prescribed contact angle boundary condition.
Integrated Analysis of the Mechanisms of Da‐Chai‐Hu Decoction in Type 2 Diabetes Mellitus by a Network Pharmacology Approach
Authors: Ren Beida , Tan Ling , Xiong Yiliang , Ji Wenting , Mu Jie , Pei Yuying , Cheng Fafeng , Wang Xueqian , Wang Qingguo
Published: April 2020

Background. The incidence of type 2 diabetes mellitus (T2DM) has increased year by year, which not only seriously affects people’s quality of life, but also imposes a heavy economic burden on the family, society, and country. Currently, the pathogenesis, diagnosis, and treatment of T2DM are still unclear. Therefore, exploration of a precise multitarget treatment strategy is urgent. Here, we attempt to screen out the active components, effective targets, and functional pathways of therapeutic drugs through network pharmacology with taking advantages of traditional Chinese medicine (TCM) formulas for multitarget holistic treatment of diseases to clarify the potential therapeutic mechanism of TCM formulas and provide a systematic and clear thought for T2DM treatment. Methods. First, we screened the active components of Da‐Chai‐Hu Decoction (DCHD) by absorption, distribution, metabolism, excretion, and toxicity (ADME/T) calculation. Second, we predicted and screened the active components of DCHD and its therapeutic targets for T2DM relying on the Traditional Chinese Medicine Systems Pharmacology Analysis Platform (TCMSP database) and Text Mining Tool (GoPubMed database), while using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) to obtain T2DM targets. Third, we constructed a network of the active component‐target, target‐pathway of DCHD using Cytoscape software (http://cytoscape.org/,ver.3.5.1) and then analyzed gene function, related biological processes, and signal pathways through the DAVID database. Results. We screened 77 active components from 1278 DCHD components and 116 effective targets from 253 ones. After matching the targets of T2DM, we obtained 38 important targets and 7 core targets were selected through further analysis. Through enrichment analysis, we found that these important targets were mainly involved in many biological processes such as oxidative stress, inflammatory reaction, and apoptosis. After analyzing the relevant pathways, the synthetic pathway for the treatment of T2DM was obtained, which provided a diagnosis‐treatment idea for DCHD in the treatment of T2DM. Conclusions. This article reveals the mechanism of DCHD in the treatment of T2DM related to inflammatory response and apoptosis through network pharmacology, which lays a foundation for further elucidation of drugs effective targets.
BTK Inhibitors in Cancer Patients with COVID-19: “The Winner Will be the One Who Controls That Chaos” (Napoleon Bonaparte)
Authors: Chong Elise A. , Roeker Lindsey E. , Shadman Mazyar , Davids Matthew S. , Schuster Stephen J. , Mato Anthony R.
Published: April 2020

As the SARS-CoV-2 (COVID-19) pandemic spreads and the number of Bruton's tyrosine kinase inhibitor (BTKi)-treated COVID-19-affected patients grows, we must consider the pros and cons of BTKi discontinuation for our patients. In favor of BTKi continuation, BTK plays an active role in macrophage polarization. By modulating key transcription factors, BTK may regulate macrophage polarization downstream of classic M1 and M2 polarizing stimuli and mitigate the hyperinflammatory state associated with COVID-19. In favor of BTKi discontinuation, we note a potentially increased risk of secondary infections and impaired humoral immunity. We hypothesize that the potential benefit of blunting a hyperinflammatory response to SARS-CoV-2 through attenuation of M1 polarization outweighs the potential risk of impaired humoral immunity, not to mention the risk of rapid progression of B-cell malignancy following BTKi interruption. On the basis of this, we suggest continuing BTKi in patients with COVID-19.
miR-106a Regulates Cell Proliferation and Autophagy by Targeting LKB1 in HPV-16–Associated Cervical Cancer
Authors: Cui Xiujie , Wang Xiao , Zhou Xiaoqing , Jia Jihui , Chen Hanxiang , Zhao Weiming
Published: April 2020

miR-106a is aberrantly regulated in various tumors and plays an important role in carcinogenesis. However, the biological role and molecular mechanism by which miR-106a contributes to cervical squamous cell carcinoma (CSCC) remains elusive. In this study, we verified that miR-106a was elevated in both human papilloma virus (HPV) 16-positive CSCC tissues and cell lines. ROC curve analysis showed that miR-106a could well distinguish HPV-16–positive CSCC tissues from normal cervical squamous epithelium tissues. High expression of miR-106a was associated with malignant clinicopathologic parameters in CSCC tissues. Exogenous expression of miR-106a greatly promoted cervical cancer cell proliferation while attenuated autophagy. Furthermore, a novel target of miR-106a, liver kinase B1 (LKB1), a proven tumor suppressor in cervical cancer was verified. Here we confirmed LKB1 was negatively correlated with malignant clinicopathologic parameters in CSCC tissues. Overexpression of LKB1 neutralized the effect of miR-106a on proliferation and autophagy in cervical cancer cell lines. In addition, the role of miR-106a in cell proliferation and autophagy was via LKB1 and its downstream pathway AMP-activated protein kinase-mammalian target of rapamycin. Of note, miR-106a was upregulated by HPV-16 E7 protein. The function of HPV-16 E7 to cell proliferation was suppressed when knockdown miR-106a in HPV-16 E7–expressing cells.

Implications:

Our study highlights the tumorigenic role and regulatory mechanism of miR-106a in CSCC. miR-106a may be a potential therapeutic target in HPV-associated cervical cancer.
Design and Development of Novel Pyrazole-Thiadiazole Derivatives as NF-ĸB Inhibitor and Cardioprotective Effect against Isoproterenol Induced Myocardial Infarction in Sprague-Dawley Rats
Authors: Wang Jianfei , Guo Yan , Wu Xue , Zhang Yanfang
Published: April 2020

The present study was aimed to discover novel pyrazole-thiadiazole derivatives as potent NF-ĸB inhibitor and its cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. The designed analogues showed potent inhibition of NF-κB transcriptional activity in luciferase assay. Among the tested derivatives, compound 6c revealed as a potent inhibitor of NF-κB. It has been found that 6c exerts protective effect via multiple mechanisms against MI, such as the levels of various cardiac injury biomarkers (creatine kinase, creatine kinase myocardial band, aminotransferase, alanine aminotransferase and lactate dehydrogenase) were found to be decreased after 6c administration as compared to ISO group. The effect of 6c was also investigated on oxidative stress via quantifying the level of various biomarkers (MDA, MPO, superoxide dismutase, and glutathione peroxidase-1). In histopathology analysis, 6c showed restoration of microstructural changes in cardiac tissues as compared to the ISO-treated group. The groups treated by 6c groups showed dose-dependent significant reduction of cell count in TUNEL analysis. In Western blot analysis, 6c causes significant modulation of Bcl2 family proteins and inhibition of phosphorylation of NF-κB and IκBα. It could be suggested that 6c exerts protective action against MI via modulation of apoptosis and oxidative stress, Bcl-2 genes, and NF-κB.
Combination of “Markers” and the Consequent Importance of Fetal Abdominal Circumference in the First Trimester for Predicting Complications Specific to Monochorionic Twin Pregnancies
Authors: Radhakrishnan Prathima , Thakar Saket , Chauhan Satyajit , Acharya Veena , Shettikeri Anitha
Published: April 2020

Background: Multifetal pregnancies are considered high-risk pregnancies compared to singleton pregnancies. Monochorionic diamniotic (MCDA) twin pregnancies tend to have a more complicated intrauterine course than their dichorionic counterparts. The most common complications are twin-to-twin transfusion syndrome (TTTS), selective fetal growth restriction (sFGR), and unexplained intrauterine fetal demise (IUFD). Early recognition of pregnancies at risk of developing complications will be helpful for counselling the parents and preparing them for necessary interventions in case a complication arises. Objectives: The aim of our study was to assess the role of discordant crown-rump length (dCRL), discordant nuchal translucency (dNT), and discordant abdominal circumference (dAC) measurements in isolation and in combination at the 11–13+6 weeks’ scan in predicting the development of TTTS, sFGR, and IUFD. Methods: All MCDA twin pregnancies with structurally normal, both live fetuses at the 11–13+6 weeks’ scan were followed up by FMF (Fetal Medicine Foundation)-certified operators for development of TTTS, sFGR, and single/double IUFD until delivery. Discordance of CRL, NT, and AC of more than or equal to 10% was considered a “marker,” and its presence was correlated with the occurrence of specific antenatal complications, i.e., TTTS, sFGR, and single or double IUFD. Results: Combination of two markers predicted MCDA-related complications in the majority of cases (70.8% positive predictive value). Combination of dNT and dAC was the strongest predictor (80% positive predictive value). Conclusions: In our population of MC twin pregnancies, dCRL, dNT, and dAC at the 11+0–13+6 weeks’ scan, in isolation, had a low predictive value for antenatal complications, i.e., TTTS, sFGR, and single/double IUFD. However, the presence of at least two markers in the first trimester could predict complications in the majority of these pregnancies. The combination of dNT and dAC appears to be the best.
Insight into Atrial Fibrillation in LVAD Patients: From Clinical Implications to Prognosis
Authors: Sisti Nicolò , Mandoli Giulia Elena , Sciaccaluga Carlotta , Valente Serafina , Mondillo Sergio , Cameli Matteo
Published: April 2020

The use of left ventricular assist devices (LVADs), whether for destination therapy or bridge to transplantation, has gained increasing validation in recent years in patients with advanced heart failure. Arrhythmias can be the most challenging variables in the management of such patients but the main attention has always been focused on ventricular arrhythmias given the detrimental impact on mortality. Nevertheless, atrial fibrillation (AF) is the most common rhythm disorder associated with advanced heart failure and may therefore characterize the LVADs’ pre- and postimplantation periods. Indeed, the consequences of AF in the population suffering from standard heart failure may require a more comprehensive evaluation in the presence of or in sight of an LVAD, making the AF clinical management in these patients potentially complex. Several studies have been based on this subject with different and often conflicting results, leaving many questions unresolved. The purpose of this review is to summarize the main pieces of evidence about the clinical impact of AF in LVAD patients, underlining the main implications in terms of hemodynamics, thromboembolic risk, bleeding and prognosis. Therapeutic considerations about the clinical management of these patients are also made according to the latest evidence.
Reconstructing the History of Machado-Joseph Disease
Authors: Meira Alex Tiburtino , Pedroso José Luiz , Boller François , Franklin Gustavo Leite , Barsottini Orlando Graziani Povoas , Teive Hélio Afonso Ghizoni
Published: April 2020

Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3, was originally described in members of the families of Machado, Thomas, and Joseph from São Miguel Island, Azores, Portugal, in 1972. The purpose of this article is to present previous descriptions of hereditary ataxia resembling the heterogeneous phenotypic intra-familiar presentation of MJD. We suggest that the condition would best be called dominant spino-pontine atrophy.
Novel Clinical Criteria Allow Detection of Short Stature Homeobox-Containing Gene Haploinsufficiency Caused by Either Gene or Enhancer Region Defects
Authors: Joustra Sjoerd D. , Kamp Gerdine A. , Stalman Susanne E. , Donze Stephany H. , Losekoot Monique , Kant Sarina G. , de Bruin Christiaan , Oostdijk Wilma , Wit Jan M.
Published: April 2020

Introduction: Short stature homeobox-containing gene (SHOX) haploinsufficiency is associated with short stature, Madelung deformity and mesomelia. Current clinical screening tools are based on patients with intragenic variants or deletions. However, recent discoveries showed that deletions of the enhancer elements are quite common. The majority of these patients show less body disproportion and respond better to recombinant human growth hormone treatment. We redefined clinical criteria for genetic analysis to facilitate detection of the full spectrum of SHOX haploinsufficiency. Methods: We analyzed 51 children with SHOX variants or deletions and 25 children with a deletion in its enhancer region. Data were compared to 277 children referred for suspicion of growth failure without endocrine or genetic pathology. Results: Only half of the patients with an enhancer region deletion fulfilled any of the current screening criteria. We propose new clinical criteria based on sitting height to height ratio >1 SDS or arm span ≥3 cm below height, with a sensitivity of 99%. When these criteria are combined with obligatory short stature, the sensitivity to detect SHOX haploinsufficiency is 68.1%, the specificity 80.6%, and the number needed to screen 21 patients. Conclusion: Novel clinical criteria for screening for SHOX haploinsufficiency allow the detection of patients within the full genetic spectrum, that is, intragenic variants and enhancer region deletions.
Porta Hepatis Injury during Laparoscopic Cholecystectomy
Authors: Shammout Reem , Al Habbal Raiean , Rayya Fadi
Published: April 2020

Iatrogenic porta hepatis injury is a rare but devastating surgical complication of laparoscopic cholecystectomy. There are no systematic studies examining the best treatment strategy in patients with this injury. We present a case of a 23-year-old woman with a large abscess in the right hepatic lobe due to an extreme vasculobiliary injury after laparoscopic cholecystectomy. Although rare, the impact of vasculobiliary injuries after cholecystectomy highlights the need for constant alertness and prompt management in order to minimize mortality and morbidity usually associated with the routine operative procedure.
Translating transmissibility measures into recommendations for coronavirus prevention
Authors: Diaz-Quijano Fredi Alexander , Rodriguez-Morales Alfonso Javier , Waldman Eliseu Alves
Published: April 2020

The rapid increase in clinical cases of the new coronavirus disease, COVID-19, suggests high transmissibility. However, the estimates of the basic reproductive number reported in the literature vary widely. Considering this, we drew the function of contact-rate reduction required to control the transmission from both detectable and undetectable sources. Based on this, we offer a set of recommendations for symptomatic and asymptomatic populations during the current pandemic. Understanding the dynamics of transmission is essential to support government decisions and improve the community’s adherence to preventive measures.
Genetically Determined Birthweight Associates With Atrial Fibrillation
Authors: Kember Rachel L. , Levin Michael G. , Cousminer Diana L. , Tsao Noah , Judy Renae , Schur Gayatri M. , Lubitz Steven A. , Ellinor Patrick T. , McCormack Shana E. , Grant Struan F.A. ,   Regeneron Genetics Center, Rader Daniel J. , Voight Benjamin F. , Damrauer Scott M.
Published: April 2020

Background:

Atrial fibrillation is a common cardiovascular disorder, characterized by irregular electrical activity in the upper chambers of the heart. Both chronic cardiometabolic risk factors and genetics have been shown to contribute to the development of atrial fibrillation. Birthweight has also been associated with risk of atrial fibrillation.

Methods:

In the current study, we utilized a genetic approach to study the effect of birthweight on atrial fibrillation. We used 2-sample Mendelian randomization to consider the impact of birthweight on incident atrial fibrillation using summary data from the Early Growth Genetics Consortium GWAS of birthweight and a large biobank-based GWAS of atrial fibrillation.

Results:

Using the framework of 2-sample Mendelian randomization, we found that a 1-SD genetic elevation of birthweight was associated with increased risk of atrial fibrillation (odds ratio, 1.27 [95% CI, 1.14–1.41];
P
=1×10
−5
) with sensitivity analyses demonstrating robustness of this result.

Conclusions:

Our findings clarify the directionality of the relationship between birthweight and atrial fibrillation, supporting the growing body of evidence that intrauterine growth has a lifelong impact on cardiovascular health.
Nonequilibrium Statistical Mechanics of Continuous Attractors
Authors: Zhong Weishun , Lu Zhiyue , Schwab David J. , Murugan Arvind
Published: April 2020

Continuous attractors have been used to understand recent neuroscience experiments where persistent activity patterns encode internal representations of external attributes like head direction or spatial location. However, the conditions under which the emergent bump of neural activity in such networks can be manipulated by space and time-dependent external sensory or motor signals are not understood. Here, we find fundamental limits on how rapidly internal representations encoded along continuous attractors can be updated by an external signal. We apply these results to place cell networks to derive a velocity-dependent nonequilibrium memory capacity in neural networks.
A new species of the genus Dahira Moore (Lepidoptera: Sphingidae) from
Sichuan, China
Authors: JIANG ZHUO-HENG , WANG CHENG-BIN
Published: April 2020

A new species of hawkmoth, Dahira sichuanica sp. nov. (Lepidoptera, Sphingidae, Macroglossinae, Macroglossini), is described based on a single male from an evergreen broad-leaf forest in Dafengding Nature Reserve, Leshan, Sichuan, China. The habitus and diagnostic features of the new species are described and illustrated. A list of all Dahira species presently known from China and the distribution map of the new species are also given.
Startup Supplier Programs: A New Model for Managing Corporate-Startup Partnerships
Authors: Kurpjuweit Stefan , Wagner Stephan M.
Published: April 2020

Collaborations between established firms and startups are increasingly considered an ingredient of corporate strategy. This article describes a startup collaboration model that has emerged in practice, a model that complements today’s predominantly used engagement vehicles of corporate accelerators and corporate venture capital. Startup supplier programs are outside-in programs that enable firms to get access to innovations that increase competitiveness of products or productivity of processes by engaging with startups based upon supplier relationships. This article presents empirical data from companies that have run successful startup supplier programs, and it explores the firms’ reasons for implementing these programs, identifies key elements of startup supplier programs, and determines how firms can run them effectively.
The possibility of disalienated work: Being at home in alternative organizations
Authors: Kociatkiewicz Jerzy , Kostera Monika , Parker Martin
Published: April 2020

Work organizations have long employed various management techniques in order to maximize workers’ engagement, which in itself implies that ‘alienation’ at work is common. One of the central descriptions of alienation in classic writings is the idea of not being ‘at home’ while at work. In this article, however, we explore its obverse, which we term ‘disalienation’ – a relationship to work based on assumptions concerning control and agency, aided by collective participatory mechanisms for identity construction and dialogical building of social relationships. We suggest that the concept and experience can be productively explored in the context of organizations which are owned and controlled by workers. Using ethnographic case studies from two Polish co-operatives, we discuss the potential characteristics of a disalienating relation to a work organization and suggest that co-operatives can provide a way for workers to be ‘at home’ while they are at work.
The performance of researchers in multidisciplinary research groups: does social capital matter?
Authors: Martín-Alcázar Fernando , Ruiz-Martínez Marta , Sánchez-Gardey Gonzalo
Published: April 2020

The aim of this article is to discuss the relationship between disciplinary diversity (multidisciplinarity) and the performance of researchers, exploring the moderating role of social capital. The article contributes to the literature explaining the internal processes of multidisciplinary research units and how they affect the scientific performance of researchers. Furthermore, the article explores the potential moderating role of social capital and how relational dynamics can mitigate the potential problems associated with multidisciplinarity. To test the hypotheses proposed, we performed a quantitative study based on a sample of 155 researchers in the field of academic management. Multiple regression analysis was used in the empirical analysis. The findings suggest that a positive relationship between researchers’ performance and multidisciplinarity exists (an inverted U-shaped relationship). Estimations also show that internal social capital moderates this curvilinear relationship, making it possible to achieve higher research performance at higher levels of multidisciplinarity.
The Effect of Links and Excerpts on Internet News Consumption
Authors: Roos Jason M.T. , Mela Carl F. , Shachar Ron
Published: April 2020

Internet news and search sites often excerpt content from and link to competing news outlets. On the one hand, providing outbound links can make the linking site more attractive, even to the point of stealing traffic from the linked sites. Regulatory policy, such as the European Union’s Copyright Directive Article 15 taxing links, is predicated in part on this idea. On the other hand, receiving inbound links can increase a linked site’s audience by informing readers about its news content that day. To explore these opposing perspectives, the authors develop a dynamic learning model and fit it to browsing and link data from celebrity news sites. They then simulate how banning links affects consumer browsing and find that linking increases celebrity news consumption, especially among consumers who browse the least. On average, linking benefits both the linking and linked sites. The authors estimate that exposure to a link increases the likelihood of visiting the linked site by .14%. This increase is approximately three times the commonly reported click-through rate for paid display advertisements.
An interactive model of democratic peace
Authors: Altman David , Rojas-de-Galarreta Federico , Urdinez Francisco
Published: April 2020

Democracies do not take up arms against each other. Although this axiom has attained the status of a mantra in the field of international relations, this statement is much more complex than it appears, in part because it is highly contingent on the definitions and operationalizations of both democracy and conflict. This article revisits democratic peace theory, combining both institutional constraints and similarity-based arguments. Interactions between the democratic level of the dyad (the average democratic level of its members) and its democratic spread (difference between the democratic scores of its members) create a dyadic triangle that encompasses all possible combinations of cases, revisiting which dyads are more prone to conflict. The findings partially confirm and partially refute both the institutional constraints and the similarity-based arguments, leading to a nuanced alternative theory: the Interactive Model of Democratic Peace. Akin to democratic peace theory, our evidence shows that the higher a dyad’s level of democracy is, the lower the probability of fatal militarized interstate disputes between that pair of states. However, contrary to democratic peace theory, we find that dissimilar-regime dyads can still be peaceful as long as they have a high mean of democracy. Following the theory of regime similarity, we consider the democratic spread of each dyad, but we find that being similar is not a sufficient condition for peace between the members of a dyad. From the empirical evidence, the article derives three heuristic zones of conflict, filling much of the gray area that has been left unexplained by previous models.
Riots and resources: How food access affects collective violence
Authors: Heslin Alison
Published: April 2020

How does food access affect the mobilization of collective violence? The upsurge in rioting in 2008 drew broad attention to the relationship of food and conflict, as scholars and policymakers sought to understand the mobilization and variation of rioting events. Studies have shown a robust relationship between conflict and food prices, noting an increase in incidents of violent conflict during times of high global prices. This study furthers the theory on the role of food access in riot mobilization, investigating the mechanisms by which changes in food access translate into collective violence. Using detailed, first-hand accounts of rioting in 2007 and 2008, this study investigates the motives and grievances of the community members where riots occurred and the relationship of those grievances to food access, while contrasting these accounts to communities that did not engage in rioting. In the cases presented, a change in food access motivated protest and violence involving existing grievances rather than explicitly addressing food access. In this way, food changed the meaning and severity of existing grievances. The cases studied add to our understanding of concurrent upsurges in food riots by outlining the ways that food access interacts with local contexts to initiate violent conflict, stressing the presence of existing actors who use decreased food access to mobilize resources to address existing grievances. While media accounts highlighted food access as the primary concern of food rioters, this study argues that many ‘food riots’ were not, in fact, directly motivated by food access. Rather, changes to food access can aid in mobilizing protests around a range of grievances, some unrelated to food access. Efforts to address the causes of food-related instability will be unsuccessful if they focus solely on food access without addressing the primary motivating grievance and understanding how food access relates to that grievance.
Effect of jade nanoparticle content and twist of cool-touch polyester filaments on comfort performance of knitted fabrics
Authors: Yang Yang , Yu Xin , Wang Xungai , Sun Yanlin , Zhang Peihua , Liu Xin
Published: April 2020

Cool-touch polyester knitted fabrics with excellent thermal-wet and cooling comfort ability are desired for summer and sports clothing. Jade nanoparticle content and twist of filaments have significant effects on comfort-related properties. In this work, the effects of jade content and twist level of two types of cross-section polyester filament on fabric comfort-related properties were investigated in detail. Filaments were prepared and further knitted to fabric samples. The physical performance of polyester filaments, the thermal-wet transfer properties and dynamic cooling property of their fabrics were measured and analyzed. It was found that the jade nanoparticles mainly affected thermal transfer property of fabrics, and the best thermal transfer was exhibited by fabric with 7% cool-touch PET chip. With the increase of twist level, air permeability, water spreading and drying performance improved but thermal transfer ability decreased, and lower twist level of yarns was beneficial for achieving real moisture cooling properties. These results showed a major advance in developing thermal-wet comfort knitted fabrics using cool-touch filaments with appropriate twist level.
Interactions in Fixed Effects Regression Models
Authors: Giesselmann Marco , Schmidt-Catran Alexander W.
Published: April 2020

An interaction in a fixed effects (FE) regression is usually specified by demeaning the product term. However, algebraic transformations reveal that this strategy does not yield a within-unit estimator. Instead, the standard FE interaction estimator reflects unit-level differences of the interacted variables. This property allows interactions of a time-constant variable and a time-varying variable in FE to be estimated but may yield unwanted results if both variables vary within units. In such cases, Monte Carlo experiments confirm that the standard FE estimator of x ⋅ z is biased if x is correlated with an unobserved unit-specific moderator of z (or vice versa). A within estimator of an interaction can be obtained by first demeaning each variable and then demeaning their product. This “double-demeaned” estimator is not subject to bias caused by unobserved effect heterogeneity. It is, however, less efficient than standard FE and only works with T > 2.
Public Administration and Macroeconomic Issues: Is This the Time for a Marriage Proposal?
Authors: Han Yanbing , Xiong Min , Frank Howard A.
Published: April 2020

A number of Public Administration (PA) scholars have raised concerns regarding the discipline’s neglect of macroeconomic challenges. Our article focuses on the link between macroeconomic trends and PA. We submit that PA needs to address changing economic structure, shrinking workforce, growing financial leverage, and rising wealth inequity to maintain relevance. Study of these trends complements PA research on government revenue reform and economic development. Furthermore, we suggest PA rebalances its underlying assumptions regarding intellectual boundaries and view of human nature. Without a paradigm shift, PA may lose any legitimate claim to be an appropriate administrative science.
Supporting and Recognizing Excellence in Teaching: STP at 75
Authors: Hill G. William , Pusateri Thomas P. , Smith Randolph A. , Beins Bernard C. , Noble Linda M.
Published: April 2020

Established in 1945 as Division 2, one of the original divisions of the American Psychological Association, the Society for the Teaching of Psychology (STP) celebrates its 75th anniversary in 2020. On the occasion of STP’s 50th anniversary, Wight and Davis published a history of the Division’s first 50 years. Using that history, we summarize STP’s first 50 years and then focus on developments and changes during the last 25 years. We believe that STP has experienced greater change and growth in the last 25 years than it did in the first 50 years.
From concrete walls to digital walls: transmedia construction of place myth in Ihwa Mural Village, South Korea
Authors: Oh Youjeong
Published: April 2020

Media representation is not a neutral site for reflection of reality, but a process through which discourses are constructed and circulated. When presented in media, urban space is re-mediated and its meanings are newly configured. Discursive currents do not simply remain in the media sphere, but reshape the cultural economy of certain places by attracting tourists and inducing property value increases. This article examines the process in which Ihwa Mural Village, a disenfranchised residential neighborhood in South Korea, has become one of the ‘best photo spots’ for tourists through representation via three distinct types of media – murals, popular culture, and Instagram. The analyses focus on the double functions of each medium: branding function to create particular place meanings, on the one hand, and power to create distance between representation and community realities on the other. This dual tendency is reinforced by transmedia dynamics. When featured in diverse media, images of Ihwa Village proliferate, attracting more participants and enabling further transmedia interactions. Yet, transmedia image flows accentuate only visual and aesthetic qualities of place. The expansive and subtractive transmedia construction consolidates the place myth, while the same process advances its detachment from the reality of the place.
Informal Caregiving and Social Capital: A Social Network Perspective
Authors: Roth Adam R.
Published: April 2020

A large literature emphasizes the importance of social relationships during the caregiving process. Yet these issues are seldom presented in a social network framework that examines the structure of caregivers’ personal networks. In this study, I examine how older caregivers experience changes in personal network structure. Using two waves from the National Social Life, Health, and Aging Project, I investigate whether caregivers are more or less likely to exhibit bridging or bonding capital potential compared to noncaregivers. I find that older adults transitioning into caregiving are more likely to develop the ability to bridge social ties within their personal networks than noncaregivers despite potential constraints in their personal freedom. Caregivers in the latter stages, meanwhile, do not differ from noncaregivers in terms of network change. These findings have implications for older adults’ potential to pool resources across social domains as well as negotiate stress and well-being during the caregiving process.
A Surgical Safety Checklist for Performing Tracheotomy in Patients with Coronavirus Disease 19
Authors: Portugal Louis G. , Adams Dara R. , Baroody Fuad M. , Agrawal Nishant
Published: April 2020

Performance of tracheotomy is a potential necessary step in the patient with coronavirus disease 19 (COVID‐19) and prolonged mechanical ventilation. Due to viral aerosolization, tracheotomy carries a high risk of transmission of COVID‐19 to the health care team performing the procedure. We share our institution’s surgical safety checklist for performing tracheotomy in patients with COVID‐19, including key modifications intended to mitigate risk to the surgical team.
COVID‐19 Anosmia Reporting Tool: Initial Findings
Authors: Kaye Rachel , Chang C. W. David , Kazahaya Ken , Brereton Jean , Denneny James C.
Published: April 2020

There is accumulating anecdotal evidence that anosmia and dysgeusia are associated with the COVID‐19 pandemic. To investigate their relationship to SARS‐CoV2 infection, the American Academy of Otolaryngology–Head and Neck Surgery developed the COVID‐19 Anosmia Reporting Tool for Clinicians for the basis of this pilot study. This tool allows health care providers to confidentially submit cases of anosmia and dysgeusia related to COVID‐19. We analyzed the first 237 entries, which revealed that anosmia was noted in 73% of patients prior to COVID‐19 diagnosis and was the initial symptom in 26.6%. Some improvement was noted in 27% of patients, with a mean time to improvement of 7.2 days in this group (85% of this group improved within 10 days). Our findings suggest that anomia can be a presenting symptom of COVID‐19, consistent with other emerging international reports. Anosmia may be critical in timely identification of individuals infected with SARS‐CoV2 who may be unwittingly transmitting the virus.
A Commentary on the Challenges of Telemedicine for Head and Neck Oncologic Patients during COVID‐19
Authors: Triantafillou Vasiliki , Rajasekaran Karthik
Published: April 2020

The COVID‐19 pandemic is an unprecedented and historic event that presents unique challenges to patient care to medical providers worldwide. The pandemic and the ensuing rapid changes to medical practice have particularly affected head and neck cancer surgeons and their patients. In an effort to balance the needs of our patients with the risks to patient and staff safety, we have been tasked with finding alternatives to the traditional office visit. In this commentary, we discuss how telemedicine can be incorporated into the head and neck surgery practice, the challenges that we have faced, and the dilemmas with which we have dealt in our efforts to fulfill the ongoing need for care of this unique patient population.