bluuebunny/crossref_metadata_2025 huggingface dataset:
Downregulation of CRTAC1 in Urothelial Carcinoma Promotes Tumor Aggressiveness and Confers Poor Prognosis
Authors: Li Wei-Ming , Chan Ti-Chun , Wei Yu-Ching , Li Chien-Feng , Ke Hung-Lung , Wu Wen-Jeng , Hsu Chin-Chia , Wang Shao-Chuan , Yeh Cheng-Fa
Published: September 2023

Background: Cartilage acidic protein 1 (CRTAC1) is a glycosylated calcium-binding extracellular matrix protein. The oncological functions of CRTAC1 in urothelial carcinoma (UC) of the urinary bladder (UB) and upper urinary tract (UT) have not yet been elucidated. Based on the published UBUC transcriptome data, we re-evaluated the differential expression profile of calcium ion binding–related genes (GO:0005509), and we found that CRTAC1 was the most significantly downregulated gene in UBUC progression. Therefore, we analyzed the prognostic value and biological significance of CRTAC1 expression in UC. Methods: We used immunohistochemistry to determine the CRTAC1 expression levels in 340 patients with UTUC and 295 patients with UBUC. The CRTAC1 expression was compared with the clinicopathological characteristics, and the prognostic impact of CRTAC1 on metastasis-free survival (MFS) and disease-specific survival (DSS) was evaluated. To study the biological functions of CRTAC1, the proliferation, migration, invasion, and tube formation abilities of UC-derived cells were evaluated. Results: A low CRTAC1 expression significantly correlated with high tumor stage, high histological grade, perineural invasion, vascular invasion, nodal metastasis, and high mitotic rate (all p < 0.01). Moreover, the CRTAC1 immunoexpression status was an independent prognostic factor for MFS and DSS in UBUC and UTUC patients (all p < 0.001) in the multivariate analysis. The exogenous expression of CRTAC1 suppressed the cell proliferation, invasion, and angiogenesis, and downregulated the matrix metallopeptidase 2 (MMP2) level in BFTC909 and T24 cells. Conclusions: CRTAC1 may participate in progression of UC and serve as a prognostic marker for metastasis. Low CRTAC1 expression was significantly associated with aggressive UC characteristics and worse clinical outcomes. The inclusion of CRTAC1 immunoexpression in the standard pathological variables may optimize the risk stratification of patients.
The Role of Mitochondrial Dysfunction in the Development of Acute and Chronic Hepatitis С
Authors: Blagov Alexander , Sukhorukov Vasily , Orekhova Varvara , Postnov Anton , Popov Mikhail , Orekhov Alexander
Published: September 2023

Currently, the issue relating to the discussion raised in this article appears to be for what purposes the hepatitis C virus (HCV) modulates cellular processes, such as antiviral defense, metabolism, apoptosis, and mitochondrial dynamics, by inhibiting the activity or expression of mitochondrial proteins and a number of cellular proteins. Additionally, to what pathological changes do these alterations lead? Thus, the aim of this review is to propose potential protein mitochondrial targets of HCV for the future development of new drugs aimed at inhibiting its interaction with cellular proteins. Considering current analyses in the literature, promising targets for the acute and chronic phases of HCV are proposed which include mitochondrial antiviral signaling (MAVS) (antiviral response protein), Parkin (mitophagy protein), Drp1 (mitochondrial fission protein), subunits 1 and 4 of the electron transport chain (ETC) complex (oxidative phosphorylation proteins), among others. This review illustrates how viral strategies for modulating cellular processes involving HCV proteins differ in the acute and chronic phases and, as a result, the complications that arise.
Status of β1-Adrenoceptor Signal Transduction System in Cardiac Hypertrophy and Heart Failure
Authors: Dhalla Naranjan S. , Bhullar Sukhwinder K. , Adameova Adriana , Mota Karina Oliveira , Vasconcelos Carla Maria Lins de
Published: September 2023

Although β1-adrenoceptor (β1-AR) signal transduction, which maintains cardiac function, is downregulated in failing hearts, the mechanisms for such a defect in heart failure are not fully understood. Since cardiac hypertrophy is invariably associated with heart failure, it is possible that the loss of β1-AR mechanisms in failing heart occurs due to hypertrophic process. In this regard, we have reviewed the information from a rat model of adaptive cardiac hypertrophy and maladaptive hypertrophy at 4 and 24 weeks after inducing pressure overload as well as adaptive cardiac hypertrophy and heart failure at 4 and 24 weeks after inducing volume overload, respectively. Varying degrees of alterations in β1-AR density as well as isoproterenol-induced increases in cardiac function, intracellular Ca2+-concentration in cardiomyocytes and adenylyl cyclase activity in crude membranes have been reported under these hypertrophic conditions. Adaptive hypertrophy at 4 weeks of pressure or volume overload showed unaltered or augmented increases in the activities of different components of β1-AR signaling. On the other hand, maladaptive hypertrophy due to pressure overload and heart failure due to volume overload at 24 weeks revealed depressions in the activities of β1-AR signal transduction pathway. These observations provide evidence that β1-AR signal system is either unaltered or upregulated in adaptive cardiac hypertrophy and downregulated in maladaptive cardiac hypertrophy or heart failure. Furthermore, the information presented in this article supports the concept that downregulation of β1-AR mechanisms in heart failure or maladaptive cardiac hypertrophy is not due to hypertrophic process per se. It is suggested that a complex mechanism involving the autonomic imbalance may be of a critical importance in determining differential alterations in non-failing and failing hearts.
Clinical Validation of Explainable Deep Learning Model for Predicting the Mortality of In-Hospital Cardiac Arrest Using Diagnosis Codes of Electronic Health Records
Authors: Chi Chien-Yu , Moghadas-Dastjerdi Hadi , Winkler Adrian , Ao Shuang , Chen Yen-Pin , Wang Liang-Wei , Su Pei-I , Lin Wei-Shu , Tsai Min-Shan , Huang Chien-Hua
Published: September 2023

Background: Using deep learning for disease outcome prediction is an approach that has made large advances in recent years. Notwithstanding its excellent performance, clinicians are also interested in learning how input affects prediction. Clinical validation of explainable deep learning models is also as yet unexplored. This study aims to evaluate the performance of Deep SHapley Additive exPlanations (D-SHAP) model in accurately identifying the diagnosis code associated with the highest mortality risk. Methods: Incidences of at least one in-hospital cardiac arrest (IHCA) for 168,693 patients as well as 1,569,478 clinical records were extracted from Taiwan’s National Health Insurance Research Database. We propose a D-SHAP model to provide insights into deep learning model predictions. We trained a deep learning model to predict the 30-day mortality likelihoods of IHCA patients and used D-SHAP to see how the diagnosis codes affected the model’s predictions. Physicians were asked to annotate a cardiac arrest dataset and provide expert opinions, which we used to validate our proposed method. A 1-to-4-point annotation of each record (current decision) along with four previous records (historical decision) was used to validate the current and historical D-SHAP values. Results: A subset consisting of 402 patients with at least one cardiac arrest record was randomly selected from the IHCA cohort. The median age was 72 years, with mean and standard deviation of 69 ± 17 years. Results indicated that D-SHAP can identify the cause of mortality based on the diagnosis codes. The top five most important diagnosis codes, namely respiratory failure, sepsis, pneumonia, shock, and acute kidney injury were consistent with the physician’s opinion. Some diagnoses, such as urinary tract infection, showed a discrepancy between D-SHAP and clinical judgment due to the lower frequency of the disease and its occurrence in combination with other comorbidities. Conclusions: The D-SHAP framework was found to be an effective tool to explain deep neural networks and identify most of the important diagnoses for predicting patients’ 30-day mortality. However, physicians should always carefully consider the structure of the original database and underlying pathophysiology.
Prognosis of Patients with Hypertrophic Obstructive Cardiomyopathy: A Multicenter Cohort Study with Data-Driven Propensity Score Matching Analysis
Authors: He Ye , Ma Huihui , Sun Nian , Zeng Shengzhi , Zhang Yanru , Shu Yan , Hua Wei , Zhou Tao , Zhou Ling , Li Xiaoping
Published: September 2023

Background: Hypertrophic obstructive cardiomyopathy (HOCM) patients are reported to have a potential risk of sudden cardiac death (SCD); however, HCM with left ventricular outflow tract (LVOT) obstruction, which is regarded as a risk indicator of SCD, is doubtful since the LVOT gradient is dynamic and may be confounded by various environmental factors and routine activities. The purpose of this study was to explore the clinical prognosis of HOCM through a multicenter cohort study with data-driven propensity score matching (PSM) analysis. Methods: The cohort included 2268 patients with HCM from 1996 to 2021 in 13 tertiary hospitals. In the present study, we excluded 458 patients who underwent alcohol septal ablation (ASA) and septal myectomy (SM) surgery so 1810 HCM patients were eventually included. We developed a data-driven propensity score using 24 demographic and clinical variables to create 1:1 propensity-matched cohorts. A Cox proportional hazard regression model was constructed to assess the effect of HOCM on mortality. Results: After logit-matching, there were no significant differences in all-cause mortality (log-rank χ2 = 1.509, p = 0.22), cardiovascular mortality/cardiac transplantation (log-rank χ2 = 0.020, p = 0.89) or SCD (log-rank χ2 = 0.503, p = 0.48) between patients with HOCM and hypertrophic nonobstructive cardiomyopathy (HNCM), and according to the Cox proportional hazard regression model, LVOT obstruction was not a risk predictor in patients with HCM. Conclusions: In both matched and unmatched cohorts, there were no significant differences in clinical prognosis between HOCM and HNCM patients, and LVOT obstruction was not an independent risk predictor of prognosis in patients with HCM. Clinical Trial Registration: ChiCTR1800017330.
Incremental Value of Right Ventricular Outflow Tract Diameter in Risk Assessment of Chronic Heart Failure Patients with Implantable Cardioverter Defibrillators: Development of RVOTD-ICD Benefit Score in Real-World Setting
Authors: Huang Hao , Deng Yu , Cheng Sijing , Yu Yu , Liu Xi , Niu Hongxia , Chen Xuhua , Cai Chi , Gu Min , Hua Wei
Published: September 2023

Background: Left ventricular ejection fraction (LVEF) remains the basic reference for the prevention of sudden cardiac death (SCD) patients, while right ventricular (RV) abnormalities have now been associated with SCD risk. A modified benefit assessment tool incorporating RV function parameters in consideration of implantable cardioverter defibrillators (ICD) insertion should be taken into account. Methods: We enrolled 954 chronic heart failure (CHF) patients (age 58.8 ± 13.1 years; 79.0% male) with quantitative measurements of right ventricular outflow tract diameter (RVOTD) before ICD implantation and then divided them according to the median level of RVOTD. The predictive value of RVOTD in life-threatening ventricular tachycardia (VT)/ventricular fibrillation (VF) vs. non-arrhythmic mortality (defined as death without prior sustained VT/VF), was evaluated respectively. Based on RVOTD and other identified risk factors, a simple risk assessment tool, RVOTD-ICD benefit score, was developed. Results: A higher RVOTD level was significantly associated with an increased risk of VT/VF (per 1 standard deviation (SD) increase, hazard ratio [HR], 1.22; 95% confidence interval [CI], 1.11–1.33; p = 0.002) but not non-arrhythmic mortality (per 1 SD increase, hazard ratio, 0.93; 95% CI, 0.66–1.33; p = 0.709) after multivariable adjustment. Three benefit groups were created based on RVOTD-ICD benefit score, which was calculated from VT/VF score (younger age, higher RVOTD, diuretic use, prior non-sustainable VT, prior sustainable VT/VF) and non-arrhythmic mortality scores (older age, renin-angiotensin-aldosterone system inhibitors use, diabetes, higher left ventricular end-diastolic diameter, New York Heart Association III/IV, higher N-terminal pro-B-type natriuretic peptide levels). In the highest RVOTD-ICD benefit group, the 3-year risk of VT/VF was nearly 8-fold higher than the corresponding risk of non-arrhythmic mortality (39.2% vs. 4.8%, p < 0.001). On the contrary, the 3-year risk of VT/VF was similar to the risk of non-arrhythmic mortality (21.9% vs. 21.3%, p = 0.405) in the lowest benefit group. RVOTD-ICD benefit score system yielded improvement in discrimination for VT/VF, non-arrhythmic mortality, and all-cause mortality than Multicenter Automatic Defibrillator Implantation Trial (MADIT)-ICD benefit score in this cohort. Conclusions: Higher RVOTD was associated with significantly increased risk of sustained VT/VF in CHF patients. A simple risk assessment tool incorporating RVOTD (RVOTD-ICD benefit score) could be generalized to ICD populations, and optimize the decision-making process of ICD implantation.
Interoception, Eating Behaviour and Bodyweight in Community Dwelling Older and Younger Adults: A Systematic Review and Roadmap for Future Research
Authors: Brennan Anthony , Gaylor Chantelle , Young Hayley Anne
Published: September 2023

Interoception, the perception and interpretation of internal states, is associated with dysregulated eating and obesity. Yet, little is currently known about the associations between interoception and eating in older adults (aged 60+ years), a population at the greatest risk for weight-related harm. The aim was to determine the current level of knowledge about interoception and eating in older compared to younger adults. 64 studies were reviewed following PRISMA guidelines. The Embase, PubMed, and Scopus databases were searched up until August 2023. There was evidence that older adults were characterized by interoceptive deficits across several domains previously linked to eating and body weight, including appetitive (hunger and satiety), cardioceptive accuracy, self-reported sensibility, and the chemical senses (gustation and retronasal olfaction). However, across all domains, there were various limitations that need to be addressed before recommendations can be made. We propose a roadmap for future studies, consisting of longitudinal, population-based research, paradigms that can differentiate belief from sensation-driven interoception, multidimensional research designs, and mechanistic links to eating behavior
Pengembangan digital platform pembelajaran dengan WE BONRU untuk menstimulus minat belajar peserta didik pada materi kerajaaan dan peninggalan Hindu-Buddha di kelas VII
Authors: Nursahid  , Almubarak
Published: September 2023

Pembelajaran digital merupakan pembelajaran yang menggunakan internet dan berbasis teknologi. Hal ini karena taraf pemakaian teknologi yang berkembang dengan pesat. pembelajaran IPS sangat penting karena ilmu yang berhubungan dengan masyarakat. Kurangnya minat belajar peserta didik cenderung mengakibatkan rendahnya pengetahuan kognitif. Tujuan studi adalah merubah perspektif peserta didik dalam belajar IPS, dimulai dari besarnya minat peserta didik melalui pengembangan website edukatif mengembangkan digital platform pembelajaran dengan nama WE BONRU (we=kita, BO= Belajar online, dan RU=Seru) yang menyesuaikan kebutuhan belajar pada peserta didik. Metode riset yang digunakan menggunakan R&D (Research & Development) dengan menggunakan model pengembangan ADDIE (analysis, design, development, implementation, evaluation). Hasil penelitian menunjukan bahwa pengembangan digital platform pembelajaran IPS yakni website WE BONRU dinyatakan layak dengan nilai validasi ahli media 94,5% berarti “sangat valid” dan ahli materi 89,4% berarti “sangat valid”, praktikalitas 82,5% berarti “sangat praktis”, dan efektifitas 92% berarti “sangat efektif”. Kesimpulannya adalah WE BONRU merupakan media pembelajaran digital istimewa yang tepat digunakan dalam pembelajaran IPS pada materi kerajaan dan peninggalan Hindu-Buddha di kelas VII karena memberikan pengaruh nyata terhadap peningkatan kemampuan kognitif serta minat belajar peserta didik.
Nguồn dinh dưỡng từ côn trùng: từ ta tới tây rồi lại về ta
Authors: Hoang Vuong Quan
Published: September 2023

Một ước lượng gần đây cho rằng, thị trường thức ăn côn trùng toàn cầu sẽ đạt giá trị 9,6 tỷ USD vào năm 2030, một con số lớn khó tưởng tượng. (Kinh tế & Dự báo; ngày 23-9-2023)
Tác động của yếu tố xã hội đến phản ứng của nhà đầu tư chứng khoán cá nhân trong khủng hoảng: bằng chứng từ Trung Quốc và Việt Nam
Authors: Tri Nguyen Phuong , Van Quy Nguyen , Hoang Giang , Nguyen Minh-Hoang
Published: September 2023

Cảm xúc là yếu tố cơ bản thúc đẩy con người đưa ra quyết định và xử lý thông tin. Sợ hãi là một trong những cảm xúc phổ biến nhất ảnh hưởng đến hành vi của nhà đầu tư cá nhân trên thị trường chứng khoán. Mặc dù nhiều nghiên cứu đã được thực hiện để khám phá tác động của nỗi sợ hãi đối với hiệu quả đầu tư và hành vi giao dịch của nhà đầu tư cá nhân, nhưng vẫn còn rất ít thông tin về các yếu tố ảnh hưởng đến nỗi sợ hãi của nhà đầu tư cá nhân trong thời kỳ thị trường sụt giảm (hoặc những giai đoạn cực kỳ biến động). Vì thế, nghiên cứu này được thực hiện để tìm hiểu liệu các nguồn thông tin ảnh hưởng đến quyết định đầu tư của nhà đầu tư có ảnh hưởng đến sự sợ hãi của họ khi khủng hoảng xảy ra hay không. Nghiên cứu đã sử dụng phương pháp phân tích Bayesian Mindsponge Framework (BMF) trên bộ dữ liệu từ 1526 nhà đầu tư Trung Quốc và Việt Nam. Kết quả nghiên cứu chỉ ra rằng các nhà đầu tư tiếp cận các loại thông tin khác nhau khi đưa ra quyết định đầu tư sẽ ảnh hưởng đến tần suất phản ứng sợ hãi khác nhau. Cụ thể, các nhà đầu tư tham khảo thông tin từ chuyên gia hoặc tự phân tích khi đưa ra quyết định đầu tư ít bị đóng băng (biểu hiện của tâm lý sợ hãi) hơn trong thời kỳ thị trường sụt giảm. Ngược lại, những người đưa ra quyết định đầu tư dựa trên thông tin từ người quen hay bạn bè và trực giác sẽ bị đóng băng thường xuyên hơn. Kết quả nghiên cứu này giúp gợi ý nhà đầu tư cá nhân nên trang bị cho mình các kiến thức về tài chính cũng như tham khảo các ý kiến chuyên gia trên thị trường, hoặc những nguồn thông tin đáng tin cậy, khi đưa ra quyết định đầu tư. Bên cạnh đó, cơ quan quản lý thị trường cần có hoạt động phổ cập kiến thức về thị trường chứng khoán, hạn chế ảnh hưởng của các kênh thông tin không chính thống, và khuyến khích nhà đầu tư ít kinh nghiệm mua chứng chỉ quỹ của các quỹ đầu tư.
Seeing is (not) voting: Examining the Influence of Visual Cues on Voter Preferences with Visual Conjoint
Authors: Ortega Alberto Lopez , Radojevic Marco
Published: September 2023

Does learning political candidates’ social categories through visual cues affect voter preferences? This paper explores this question by conducting a visual conjoint survey experiment with 2,324 German voters, varying whether respondents received information on candidates through explicit labels or pretested AI-generated candidate pictures. The results confirm our expectations that the way in which social categories are learned affects preferences, with visual cues having a more significant effect on voter preferences compared to textual cues, leading to more discriminatory preferences for certain social categories. Moreover, we show that the effect of visual cues is moderated by the visibility of social categories, with visible social categories, such as gender binaries and ethnic in-/out- group, eliciting more discriminatory preferences with visual cues. The study sheds light on how the presentation of visible and unvisibilized social categories affects political candidate selection and emphasizes the importance of considering the intersectionality of social categories and their relationship with ideology.
Serendipity Science: An Emerging Field and its Methods
Authors: Copeland Samantha , Ross Wendy , Sand Martin
Published: September 2023

Serendipity is fundamental to science. This quirky and intriguing phenomenon permeates across scientific disciplines, including the medical sciences, psychological sciences, management and organizational sciences, innovation science, philosophy and library and information sciences. Why is it so ubiquitous? Because of what it facilitates and catalyzes: scientific discoveries from velcro to Viagra, innovation of all forms, unexpected encounters of useful information, novel and important ideas, and deep reflection on how we, as individuals, organizations, communities and societies can take leaps forwards by seizing unexpected opportunities and ‘making our own luck.’
Pendekatan dan Teori Birokrasi Pemerintahan
Authors: Sari Mutiara
Published: September 2023

Sistem birokrasi bukanlah hal yag baru di wilayah Indonesia, eksistensi birokrasi sudahdimulai beberapa tahun yang telah lalu. Birokrasi ini diartikan sebagai sistem pengelolaannegara dimana diperlukan pengendalian manajemen operasi pemerintahan yang baikdalam hal pelaksanaan tugasnya. Sangat disesalkan, jika kinerja aparat malah menjadisebab terjadinya masalah baru yang dapat mendorong opini masyarakat bahwa birokrasibersifat statis dan kurang peka terhadap perubahan lingkungan. Situasi seperti ini tidakjarang berpotensi adanya praktek administrasi yang condong pada korupsi, kolusi, dannepotisme. Berakar pada situasi tersebut, pemerintah pusat juga daerah memerlukanadanya reformasi pada birokrasinya dengan pertimbangan-pertimbangan tatarankehidupan nyata dibanding dengan tataran komitmen saja. Artikel ini bertujuan untukmengetahui makna birokrasi, macam pendekatan birokrasi serta teori dalam birokrasipemerintahan, dimana harus diketahui bahwa eksistensi birokrasi diperuntukkan dalammempersatukan sistem politik Indonesia.
Zelda 2 (Supplement III:34)
Authors: Akmut Camille
Published: September 2023

GCCX cont. (Supplement to the History of computer science and technology)
Control of DDX39a helicase by NOD2.
Authors: Mamoor Shahan
Published: September 2023

We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of DExD-box helicase DDX39a by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
A Conjecture On σ(n) Function
Authors: Mandal Sourav
Published: September 2023

We know many Arithmetical Functions [1] like ϕ(n),σ(n),τ(n) etc. In this paper we will discuss about σ(n) and will see a phenomenal observation.And later we will claim this observation as a conjecture.
Diagnosing colour vision deficiencies using eye movements (without the eyetracker)
Authors: Taore Aryaman
Published: September 2023

Purpose: To investigate the efficacy of a novel test for diagnosing color vision deficiencies using reflexive eye movements measured using an unmodified tablet.Methods: This study followed a cross-sectional design, where thirty-three participants aged between 17 to 65 years were recruited. The participant group comprised 23 controls, 8 deuteranopes, and 2 protanopes. An anomaloscope was employed to determine the color vision status of these participants. The study methodology involved using an Apple iPad Pro's built-in eye-tracking capabilities to record eye movements in response to colored patterns drifting on the screen. Through an automated analysis of these movements, the researchers estimated individuals' red-green equiluminant point and their equivalent luminance contrast.Results: Estimates of red-green equiluminant point and equivalent luminance contrast were used to classify participants’ colour vision status with a sensitivity rate of 90.0% and a specificity rate of 91.30%.Conclusions: The novel color vision test administered using an unmodified tablet was found to be effective in diagnosing color vision deficiencies and has the potential to be a practical and cost-effective alternative to traditional methods.Translation Relevance: The test's objectivity, its straightforward implementation on a standard tablet, and its minimal requirement for patient cooperation, all contribute to a wider accessibility of color vision diagnosis. This is particularly advantageous for demographics like children who might be challenging to engage, but for whom early detection is of paramount importance.
Tazkiyatun Nafs Said Hawwa dan Penerapannya dalam Bimbingan dan Konseling Islam
Authors: Al-Qossam Muhammad Izzuddin
Published: September 2023

Bimbingan dan konseling menjadi sebuah disiplin ilmu yang berkembang di Barat sebagai jawaban atas kebutuhan asupan spiritual yang sebelumnya banyak ditentang. Seiring berkembangnya zaman, bidang keilmuan tersebut sedikit banyak diadopsi dalam keilmuan agama Islam dan disesuaikan dengan nilai-nilai Islam, sehingga muncul sebuah disiplin ilmu baru, yaitu bimbingan dan konseling Islam. Perbedaan mendasar antara bimbingan dan konseling Islam dan konvensional adalah pada aspek spiritual. Konseling konvensional didasari atas penelitian empirik dan spekulatif. Sedangkan konseling Islam didasari atas syari’ah yang telah ditetapkan. Bahkan pembahasan tentang kejiwaan dalam agama Islam sudah dikaji sejak lama, dan dikenal istilah tazkiyatun nafs untuk mengatasi berbagai permasalahan jiwa. Salah satu tokoh yang membahas secara mendalam tentang tazkiyatun nafs adalah Imam Al-Ghazali, yang kemudian pemikirannya ditinjau ulang oleh Said Hawwa dan diringkas dalam karyanya Al-Mustakhlash Fii Tazkiyati Al-Anfus. Dalam telaah ini, didapati bahwa konsep tazkiyatun nafs Said Hawwa dapat diterapkan dalam bimbingan dan konseling Islam untuk mencapai tujuan umum maupun khususnya. Maka penulis berharap, semoga kajian ini dapat menjadi tambahan referensi dalam keilmuan bimbingan dan konseling Islam.
ROAR-CAT: Rapid Online Assessment of Reading ability with Computerized Adaptive Testing
Authors: Ma Wanjing Anya , Richie-Halford Adam , Burkhardt Amy , Kanopka Klint , Chou Clementine , Domingue Benjamin , Yeatman Jason D.
Published: September 2023

The Rapid Online Assessment of Reading (ROAR) is a web-based, lexical decision task that measures single word reading abilities in children and adults without a proctor. Here we study whether item response theory (IRT) and computerized adaptive testing (CAT) can be used to create a more efficient online measure of word recognition. To construct an item bank, we first analyzed data taken from four groups of students (N = 1,960) who differed in age, socioeconomic status, and language-based learning disabilities. The majority of item parameters were highly consistent across groups (r=0.78 - 0.94); 6 items that functioned differently across groups were removed, leaving 246 items in the final item bank. Next, we implemented a JavaScript CAT algorithm and conducted a validation experiment with 485 students in grades 1-8 who were randomly assigned to complete trials of all items in the item bank in either a) a random order vs b) an order determined by the CAT algorithm. We found that, to achieve reliability of 0.9, CAT improved test efficiency by 40%: 75 CAT items produced the same standard error of measurement as 125 items in a random order. Subsequent validation in 32 public school classrooms shows 40 CAT items (approximately 3 minutes) can achieve high correlations (r = .89 for 1st grade, r = .73 for 2nd grade) with alternative 15-20 minutes individually proctored reading assessments. Our findings suggest that ROAR-CAT is a promising tool for efficiently and accurately measuring single word reading ability in reading research and educational practice. Furthermore, our development process serves as a model for creating adaptive online assessments that bridge research and practice.
Development of the Meanness in Psychopathy – Self Report: Factor Structure, Criterion-Related Validity, and Incremental Validity
Authors: Benning Stephen D , Barchard Kimberly A. , Westfall R. Shane
Published: September 2023

Meanness is a multifaceted construct that is central to psychopathy. This study reports the development of the Meanness in Psychopathy-Self Report (MiP-SR) across three waves of MTurk data collection involving approximately 300 participants in each wave. The MiP-SR’s items were written without reference to specific antisocial behaviors, and its 26 trait scales aggregated into three factors. Malice assesses an aggressive, haughty, remorseless misuse of others. Coldness assesses an unempathetic, unemotional detachment from people. Imperviousness assesses a resistance to socially mediated negative emotions. Malice related to nearly all measures of psychopathy, narcissism and antagonism, and reduced honesty and humility. Coldness related to callous-unemotional psychopathy, detachment and restricted affectivity, and avoidant attachment along with reduced empathy. Imperviousness related to boldness and callous-affective psychopathy, reduced vulnerable narcissism and negative affectivity, and positive emotionality along with reduced anxious attachment. Together, the MiP-SR’s factors incrementally predicted most criterion-related variables beyond the Triarchic Psychopathy Measure’s Meanness scale.
An Extended Chinese Social Evaluative Word List
Authors: Lulu Li , Qingrong Chen , Chuan-Peng Hu
Published: September 2023

Social evaluation, i.e., people's views of self, others, and groups, is ubiquitous and embedded in our language. In turn, social evaluative words are used intensively in studies of human social evaluation. However, standardized Chinese word lists for social evaluation are under-developed; the only available word lists are based on the big-two model of social evaluation (i.e., agency and warmth) and cover small numbers of words. To fill the gap, we conducted a survey with a relatively large sample (n = 1270, 50% female) and a large number of words (1908) that might describe extended social evaluative dimensions: appearance, socioeconomic status, sociability, competence, and morality. The participants rated the extent to which each word described a certain social evaluation dimension and how positive/negative each word was. Based on this dataset, we selected words that dominantly describe one of the five above-mentioned dimensions. The final word list has 1040 words, including 245 appearance words (143 positive, 11 neutral, 91 negative), 108 socioeconomic status words (36 positive, 2 neutral, 70 negative), 93 sociability words (53 positive, 5 neutral, 35 negative), 261 competence words (185 positive, 4 neutral, 72 negative), and 333 morality words (149 positive, 1 neutral, 183 negative). This word list provides an extended Chinese social evaluative word list and will serve as a useful resource for researchers in social psychology, linguistics, sociology, and computational social science.
Mental health of intellectually gifted individuals: Investigating the nonlinearity of the relationship between intelligence and general mental health
Authors: Czerwiński Stanisław Konrad , Atroszko Paweł Andrzej , Konarski Roman
Published: September 2023

Despite intelligence being generally related to better mental health, individualswith extremely high levels of intelligence (also often referred to as gifted) are frequently viewed to be socially maladjusted, emotionally unstable, and eccentric. Although this view has been present for decades, the scientific data on this subject is highly inconsistent and suffers from several methodological limitations. In this study, to test whether the relationship between general intelligence and general mental health is nonlinear in such a way that at extreme values of intelligence the relationship turns from positive to a negative one the data from eight waves ofthe 1970 British Cohort Study (BCS70) was used (N range from 2,870 to 7,984), withintelligence being assessed at age 10, and mental health being assessed with several different measures at ages 16, 26, 30, 34, 42, 46 and 50. Quadratic regression, as well as spline regression, which divides the dataset into intervals, creates a separate regression for each interval and then smooths out the breakpoints were used for analyses. The results showed that the nonlinear models generally fit the data better than the corresponding linear models. At high values of intelligence, individuals might begin to experience unique issues affecting their mental health, despite their mental health being at potentially the same or higher values than those with average intelligence. Intellectually gifted individuals have a large potential to have a positive impact on the functioning of the whole society. Recognizing and understanding their problems can prove to be of great importance.
Importance of agriculture in Indian economy
Authors: Doria Rakesh
Published: September 2023

Agriculture has been the cornerstone of the Indian economy since ancient times. Agriculture is the fundamental structure of the Indian economy. Because agriculture is the main source of income for almost half of India's population. This is the reason why agriculture is considered the backbone of the Indian economy. Agriculture has an important contribution in the Indian economy, the basic reason for which is that about 60 percent of India's population is connected to the agriculture sector. Which contributes about 20 percent to India's GDP. At present, the Government of India is running many programs to increase agricultural production. Whose main objective includes improvement in agricultural sector like increase in agricultural production, financial help to farmers, use of technology in agriculture, scientific applications in agriculture, etc.

Abstract in Hindi Language:

प्राचीन काल से ही कृषि भारतीय अर्थव्यवस्था की आधारषिला रही है। कृषि भारतीय अर्थव्यवस्था का बुनिवादी ढांचा है। क्योंकि भारत के लगभग आधी जनसंख्या के आय का मुख्य स्रोत कृषि है। यही कारण है कि कृषि को भारतीय अर्थव्यवस्था का रीढ़ भी कहाँ जाता है। भारतीय अर्थव्यवस्था में कृषि का महत्वपूर्ण योगदान है, जिसका मूलभूत कारण यह है की भारत लगभग 60 प्रतिषत जनसंख्या कृषि क्षेत्र से जुड़ी हुई है। जो कि भारत की जीडीपी में लगभग 20 प्रतिषत का योगदान करती है। वर्तमान समय में भारत सरकार कृषि उत्पादन में वृद्धि के लिए अनेको कार्यक्रम चला रही हैं। जिसका मुख्य उद्देष्य कृषि क्षेत्र में सुधार जैसे - कृषि उत्पादन में वृद्धि, किसानों को आर्थिक मदद, कृषि में टेक्नोलोजी का प्रयोग, कृषि में वैज्ञानिक अनुप्रयोग, आदि शामिल है।

Keywords: अर्थव्यवस्था, सकल घरेलु उत्पाद, कृषि, जनसंख्या
Professional Misconduct & Feeble Underpinning of Government Departments in India
Authors: Nanda Hiranmaya
Published: September 2023

This work tries to explore how government agencies' shoddy foundations contribute to professional misconduct. Because it is the only profession in which the general public either benefits from or suffers because of an employee's actions, working for the government is regarded as one of the most prestigious jobs in any nation. The government department is seen as a crucial component of the nation's administrative structure since the entire department is tasked with carrying out the policies and programs designed to serve the needs of the general populace. Therefore, it is only normal to have expectations that these agencies would function properly and that public officials won't misuse the authority granted to them by behaving in an ethical, sensible, and appropriate manner. Having a government department that runs smoothly is a fantasy, though, since every department has a weak base that encourages employee malfeasance that in turn leads to harassment of the general public. The word "professional misconduct" in connection to a government agency has a broad definition and refers to a variety of behaviors, including inappropriate conduct, unethical behavior, public harassment caused by excessive delays, the use of illegal tactics, etc.
THE EFFECT OF INDIVIDUAL PERCEPTIONS OF INTERNET CONNECTION QUALITY AND DIGITAL FINANCIAL SERVICES’ PLATFORM CREDIBILITY ON THE USAGE OF DIGITAL FINANCIAL SERVICES
Authors: Rachmat Dimas Pratomo  , Dwini Handayani
Published: September 2023

Digital Financial Services (DFS) present an opportunity to expand financial access within society; however, DFS adoption remains relatively low in Indonesia. This study aims to assess how individual perceptions of internet connection quality and the credibility of DFS platforms influence their adoption in Indonesia. Utilizing data from the 2020 Digital Economy Household Survey (DEHS) and employing the probit and ordered probit estimation models, the research demonstrates a positive and significant relationship between perceptions of internet connection quality, DFS platform credibility, and the likelihood and frequency of DFS usage. Notably, a majority of DFS users fall under the "occasionally used" category, indicating usage ranging from 3 to 30 minutes per day. The study underscores the need for collaborative efforts to establish a well-distributed, trusted, and secure DFS ecosystem. This necessitates addressing regulatory frameworks, enhancing infrastructure, and improving public financial literacy to enhance user acceptance and utilization of DFS platforms.
THE IMPLICATIONS OF POPULATION AGING ON LOCAL HEALTH CARE EXPENDITURE: A 22-YEAR PANEL DATA ANALYSIS
Authors: Eyitayo Francis Adanlawo  , Nomusa Yolada Nkomo
Published: September 2023

The purpose of this study is to examine the implications of population aging on local health expenditures in South Africa. A balanced panel of annually observed observations from South Africa over the period of 22 years (1995–2017) was used. The study used gross domestic product (GDP), health expenditure, labor force, and age structure as control variables and pooled OLS, fixed effect, and random effect tests to estimate the relationships among the variables. The results show that the old-age dependency ratio, gross domestic product (GDP), unemployment rate, and gross value added (GVA) are all explanatory variables that are related to healthcare spending and are shown as a base model in the pooled OLS. The results indicate that healthcare expenditure and the old-age dependency ratio have a positive relationship in South Africa. Considering the implications for policy, this study suggests that the South African economy should account for the aging population when policies are designed and that the government should make an effort to improve the healthcare system in order to meet the demands of elderly people.
SOUTH AFRICAN DAIRY INDUSTRY AND THE USE OF INTERCULTURAL BUSINESS COMMUNICATION FOR IMPROVEMENT
Authors: Adanlawo Eyitayo Francis , Vezi-Magigaba Makhosazana Faith
Published: September 2023

The dairy industry is an important part of the highly diverse agricultural sector of South African economy. The industry is a significant contributor to the food security and it also provides many social and economic attributes to the nation. South Africa has the potential to be self-sufficient in milk production, the country currently imports fluid milk and processed dairy products. For the industry to attain a larger world market share, it has to be competitive. A proper and constant intercultural business communication (IBC) with nations that are advanced in the production of milk and dairy products is the key to improving the sector's competitiveness. In this regard, the study examines the role of innovative intercultural business communication for the improvement of South African dairy industry. A systematic review method was adopted for collection and analysis of data relevant to the study. Communication accommodation theory (CAT) was used to explain the  role  that communication plays in building relationship that will lead to improved production. The study revealed that intercultural business communication has the capacity to build relationships that will lead to improved production for dairy industries. The study recommends regular visitations to more advanced nations’ dairy farms and adequate training on language and culture. Based on the conclusion and recommendations, this study presents a platform for the dairy industries to think about an innovative intercultural business communication approach to be at a competitive edge in a global environment.
Calvarial vault remodeling including pterional decompression for the treatment of nonsyndromic scaphocephaly patients: technical note and retrospective case series
Authors: Matthijs Vincent , Vandersteene Jelle , Baert Edward
Published: September 2023

OBJECTIVE

Surgical techniques to correct scaphocephaly often rely on the implantation of foreign material and/or postoperative helmet therapy and possibly result in minimal correction of frontal bossing. Moreover, foreign material and helmet therapy are associated with extra medical care and financial costs. Frontal bossing is perceived as a prominent, disfiguring feature of scaphocephaly. Herein, authors present the results of a total cranial vault remodeling technique that corrects scaphocephaly features without relying on foreign material or postoperative helmet therapy. It includes frontal release and pterional decompression, which aim to correct frontal bossing.

METHODS

All patients who had been operated on for isolated scaphocephaly at a single institution between January 2011 and December 2020 were included in this retrospective review. Operation time, transfusion volume, hospital stay, complications, cephalic index (CI), and bossing angle (BA) were analyzed.

RESULTS

Sixty-five patients with nonsyndromic scaphocephaly were included in this analysis. Imaging to calculate the CI and BA preoperatively, immediately postoperatively, and 1 year postoperatively was available in 22 and 20 patients, respectively. The mean CI increased from 69.2% preoperatively to 74.6% postoperatively and 75.5% 1 year postoperatively. The mean BA decreased from 114.5° preoperatively to 111.6° postoperatively and 108.9° 1 year postoperatively. The mean operating time was 2 hours 4 minutes, and the median blood transfusion volume was 100 ml. There were no major complications or reoperations.

CONCLUSIONS

The described total cranial vault remodeling technique is a safe procedure that mitigates total treatment burden, as no helmet therapy or implantation of foreign material is needed. It is effective in correcting CI and results in significant frontal bossing correction. The latter is attributed to a distinctive feature of the technique: frontal release and pterional decompression.
Kemampuan penalaran matematis siswa dalam menyelesaikan soal cerita
Authors: Cahyani Nurul Dewi , Sritresna Teni
Published: September 2023

AbstractThis research is motivated by students' reasoning abilities that are still low in solving math word problems. Students still have difficulty in giving proper reasons for a problem that has been done and confusion in giving conclusions about a statement. Even reasoning skills should be needed when students solve a problem because then students will easily apply them in solving a problem. This study aims to analyze students' mathematical reasoning abilities in solving word problems. This research uses a qualitative research approach with a descriptive research type. The subjects in this study were 6 students of class VIII-C of SMP Negeri 1 Kadungora who were selected from the results of the initial test of mathematical reasoning abilities, namely 3 students with high reasoning abilities, 1 student with moderate reasoning abilities, and 2 students with low reasoning abilities. The results of this study are 1) Students with high reasoning abilities in solving word problems, namely S-2 and S-3 are able to fulfill the four indicators of reasoning. While S-1 is able to fulfill three indicators of reasoning. 2) Students with moderate reasoning abilities in solving word problems are able to fulfill two reasoning indicators, namely S-4. 3) Students with low reasoning abilities in solving word problems are only able to fulfill one reasoning indicator, namely S,-5, and S-6. Abstrak Penelitian ini dilatarbelakangi oleh kemampuan penalaran siswa yang masih rendah dalam memecahkan soal cerita matematika. Siswa masih kesulitan dalam memberikan alasan yang tepat terhadap suatu permasalahan yang telah dikerjakan serta kebingungan dalam memberikan kesimpulan terhadap suatu pernyataan. Padahal seharusnya kemampuan penalaran sangat dibutuhkan ketika siswa memecahkan suatu permasalahan, karena dengan begitu siswa akan mudah menerapkannya dalam menyelesaikan suatu permasalahan. Penelitian ini bertujuan untuk menganalisis kemampuan penalaran matematis siswa dalam menyelesaikan soal cerita. Penelitian ini menggunakan pendekatan penelitian kualitatif dengan jenis penelitian deskriptif. Subjek dalam penelitian ini sebanyak 6 siswa kelas VIII-C SMP Negeri 1 Kadungora yang dipilih dari hasil tes awal kemampuan penalaran matematis yaitu 3 siswa dengan kemampuan penalaran tinggi, 1 siswa dengan kemampuan penalaran sedang, dan 2 siswa dengan kemampuan penalaran rendah. Hasil dari penelitian ini adalah: 1) Siswa dengan kemampuan penalaran tinggi dalam menyelesaikan soal cerita yaitu S-2 dan S-3 mampu memenuhi empat indikator penalaran. Sedangkan S-1 mampu memenuhi tiga indikator penalaran. 2) Siswa dengan kemampuan penalaran sedang dalam menyelesaikan soal cerita mampu memenuhi dua indikator penalaran yaitu S-4. 3) Siswa dengan kemampuan penalaran rendah dalam menyelesaikan soal cerita hanya mampu memenuhi satu indikator penalaran yaitu S-5 dan S-6.
Pengaruh Penggunaan T2 Blade terhadap Kualitas Citra MRI Cervical Potongan Sagital pada Pasien Non-Cooperative
Authors: Sriyatun Sriyatun , Supriyaningsih Eny , Oktavianti Yasinta
Published: September 2023

Background: Using T2 BLADE in Cervical MRI examination can improve image quality because it can reduce artifacts especially with Non-Cooperative patients. The purpose of this study was to analyze the effect of T2 BLADE use on sagittal cut image quality in Non-Cooperative patients. The benefit of using T2 BLADE is that it provides insight to the reader and as an alternative in selecting the right sequence on Cervical MRI examination with Non-Cooperative patients so as to get an optimal and informative picture.Methods: The research design carried out was qualitative descriptive analytic with an observation and experimental approach which was carried out from May to June 2023 at Fatmawati Hospital using a Siemens Magnetom Altea 1.5T MRI aircraft. The population of this study was samples that performed Cervical MRI examination with a total of 6 samples. The data in this study is primary data collected by observation, experiments and questionnaires. Data processing and analysis was carried out by giving questionnaires to radiologst and radiographer who made subjective assessments and processed with simple calculations using Ms. Excel to find  the Mean.Results: The results of this study are, the image quality of Cervical MRI examination in Non-Cooperative patients  is more optimal using T2 BLADE sequences, the resulting images have quite informative results when compared to T2 TSE sequences. This study can be an option when conducting Cervical MRI examination  on Non-Cooperative patients  based on questionnaires, simple calculations and author analysis, so that patients get a diagnosis accurately and quickly.Conclusions: It can be concluded that the image quality of Cervical MRI examination in Non-Cooperative patients is  more optimal using T2 BLADE sequences, the resulting image has quite informative results. This study can be an option when conducting Cervical MRI examination  on Non-Cooperative patients  based on questionnaires, simple calculations and author analysis, so that patients get a diagnosis accurately and quickly.