bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Assessment of Water Sprays Utilization for Controlling Hydrogen Sulfide Releases in Confined Space
Authors: Zhao Dongfeng , Li Chao , Liu Jun , Zhou Guoying , Zhang Qingdong , Liu Chunshuang
Published: October 2015

This paper reported the utilization of water spray for controlling H2S release in a confined space, which is especially important in industry. A typical spray tower was modified to simulate the confined space for people's enterable routine operation (e.g., pump room), in which the dilution capacity of water sprays can also be evaluated. This work consists of two parts: the first part focuses on the influences of different operating conditions on chemical dilution capacities of water sprays in mechanisms; the second one is comparison between two nozzle configurations for evaluating their feasibilities of practical application. Water sprays express eligible performance for H2S release control even though their dilution capacity was weakened at high gaseous concentrations and rates of releases. The presence of Na2CO3can significantly improve absorption effectiveness of H2S in water and the optimal Na2CO3additive was found to be 1.0 g·L−1in this test. Compared with Na2CO3, adjusting water flow rate may be an effective strategy in enhancing dilution capacity of water sprays due to the fact that larger flow rate led to both less dilution time (TD) and dilution concentration (CD). Furthermore, multinozzle configuration is more efficient than single-nozzle configuration under the same water consumption.
Load Mitigation and Optimal Power Capture for Variable Speed Wind Turbine in Region 2
Authors: Rajendran Saravanakumar , Jena Debashisha
Published: September 2015

This paper proposes the two nonlinear controllers for variable speed wind turbine (VSWT) operating at below rated wind speed. The objective of the controller is to maximize the energy capture from the wind with reduced oscillation on the drive train. The conventional controllers such as aerodynamic torque feedforward (ATF) and indirect speed control (ISC) are adapted initially, which introduce more power loss, and the dynamic aspects of WT are not considered. In order to overcome the above drawbacks, modified nonlinear static state with feedback estimator (MNSSFE) and terminal sliding mode controller (TSMC) based on Modified Newton Raphson (MNR) wind speed estimator are proposed. The proposed controllers are simulated with nonlinear FAST (fatigue, aerodynamics, structures, and turbulence) WT dynamic simulation for different mean wind speeds at below rated wind speed. The frequency analysis of the drive train torque is done by taking the power spectral density (PSD) of low speed shaft torque. From the result, it is found that a trade-off is to be maintained between the transient load on the drive train and maximum power capture.
Searches for PromptR-Parity-Violating Supersymmetry at the LHC
Authors: Redelbach Andreas
Published: October 2015

Searches for supersymmetry (SUSY) at the LHC frequently assume the conservation ofR-parity in their design, optimization, and interpretation. In the case thatR-parity is not conserved, constraints on SUSY particle masses tend to be weakened with respect toR-parity-conserving models. We review the current status of searches forR-parity-violating (RPV) supersymmetry models at the ATLAS and CMS experiments, limited to 8 TeV search results published or submitted for publication as of the end of March 2015. All forms of renormalisable RPV terms leading to prompt signatures have been considered in the set of analyses under review. Discussing results for searches for promptR-parity-violating SUSY signatures summarizes the main constraints for various RPV models from LHC Run I and also defines the basis for promising signal regions to be optimized for Run II. In addition to identifying highly constrained regions from existing searches, also gaps in the coverage of the parameter space of RPV SUSY are outlined.
Comparing and Optimizing Nitrate Adsorption from Aqueous Solution Using Fe/Pt Bimetallic Nanoparticles and Anion Exchange Resins
Authors: Daud Muhammad , Khan Zahiruddin , Ashgar Aisha , Danish M. Ihsan , Qazi Ishtiaq A.
Published: October 2015

This research work was carried out for the removal of nitrate from raw water for a drinking water supply. Nitrate is a widespread ground water contaminant. Methodology employed in this study included adsorption on metal based nanoparticles and ion exchange using anionic resins. Fe/Pt bimetallic nanoparticles were prepared in the laboratory, by the reduction of their respective salts using sodium borohydride. Scanning electron microscope, X-ray diffraction, energy dispersive spectrometry, and X-ray florescence techniques were utilized for characterization of bimetallic Fe/Pt nanoparticles. Optimum dose, pH, temperature, and contact time were determined forNO3-removal through batch tests, both for metal based nanoparticles and anionic exchange resin. Adsorption data fitted well the Langmuir isotherm and conformed to the pseudofirst-order kinetic model. Results indicated 97% reduction in nitrate by 0.25 mg/L of Fe/Pt nanoparticles at pH 7 and 83% reduction in nitrate was observed using 0.50 mg/L anionic exchange resins at pH 4 and contact time of one hour. Overall, Fe/Pt bimetallic nanoparticles demonstrated greaterNO3-removal efficiency due to the small particle size, extremely large surface area (627 m2/g), and high adsorption capacity.
Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis
Authors: Schaub Franz X. , Reza Md. Shamim , Flaveny Colin A. , Li Weimin , Musicant Adele M. , Hoxha Sany , Guo Min , Cleveland John L. , Amelio Antonio L.
Published: October 2015

Fluorescent proteins are widely used to study molecular and cellular events, yet this traditionally relies on delivery of excitation light, which can trigger autofluorescence, photoxicity, and photobleaching, impairing their use in vivo. Accordingly, chemiluminescent light sources such as those generated by luciferases have emerged, as they do not require excitation light. However, current luciferase reporters lack the brightness needed to visualize events in deep tissues. We report the creation of chimeric eGFP-NanoLuc (GpNLuc) and LSSmOrange-NanoLuc (OgNLuc) fusion reporter proteins coined LumiFluors, which combine the benefits of eGFP or LSSmOrange fluorescent proteins with the bright, glow-type bioluminescent light generated by an enhanced small luciferase subunit (NanoLuc) of the deep-sea shrimp Oplophorus gracilirostris. The intramolecular bioluminescence resonance energy transfer that occurs between NanoLuc and the fused fluorophore generates the brightest bioluminescent signal known to date, including improved intensity, sensitivity, and durable spectral properties, thereby dramatically reducing image acquisition times and permitting highly sensitive in vivo imaging. Notably, the self-illuminating and bifunctional nature of these LumiFluor reporters enables greatly improved spatiotemporal monitoring of very small numbers of tumor cells via in vivo optical imaging and also allows the isolation and analyses of single cells by flow cytometry. Thus, LumiFluor reporters are inexpensive, robust, noninvasive tools that allow for markedly improved in vivo optical imaging of tumorigenic processes. Cancer Res; 75(23); 5023–33. ©2015 AACR.
Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells
Authors: Cao Ji , Wang Yijie , Dong Rong , Lin Guanyu , Zhang Ning , Wang Jing , Lin Nengming , Gu Yongchuan , Ding Ling , Ying Meidan , He Qiaojun , Yang Bo
Published: October 2015

Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of metastatic character. However, the connections between these phenomena are not fully understood. In this study, we define an integrative role for the E3 ubiquitin ligase subunit WSB1. In primary osteosarcomas, increased levels of WSB1 correlated with pulmonary metastatic potential. RNAi-mediated attenuation of WSB1 or disruption of its E3 ligase activity potently suppressed tumor metastasis. Quantitative proteomic and functional analyses revealed that WSB1 ubiquitylates the Rho-binding protein RhoGDI2 and promotes its proteasomal degradation, thereby activating Rac1 to stimulate tumor cell motility and invasion. Our findings show how WSB1 regulates key steps of the metastatic cascade in hypoxia-driven osteosarcoma, and they highlight a candidate therapeutic target to potentially improve the survival of patients with metastatic disease. Cancer Res; 75(22); 4839–51. ©2015 AACR.
The Impact of Misuse and Diversion of Opioid Substitution Treatment Medicines: Evidence Review and Expert Consensus
Authors: Reimer Jens , Wright Nat , Somaini Lorenzo , Roncero Carlos , Maremmani Icro , McKeganey Neil , Littlewood Richard , Krajci Peter , Alho Hannu , D''Agnone Oscar
Published: October 2015

Background/Aims: Opioid substitution treatment (OST) improves outcomes in opioid dependence. However, controlled drugs used in treatment may be misused or diverted, resulting in negative treatment outcomes. This review defines a framework to assess the impact of misuse and diversion. Methods: A systematic review of published studies of misuse and diversion of OST medicines was completed; this evidence was paired with expert real-world experience to better understand the impact of misuse and diversion on the individual and on society. Results: Direct impact to the individual includes failure to progress in recovery and negative effects on health (overdose, health risks associated with injecting behaviour). Diversion of OST has impacts on a community that is beyond the intended OST recipient. The direct impact includes risk to others (unsupervised use; unintended exposure of children to diverted medication) and drug-related criminal behavior. The indirect impact includes the economic costs of untreated opioid dependence, crime and loss of productivity. Conclusion: While treatment for opioid dependence is essential and must be supported, it is vital to reduce misuse and diversion while ensuring the best possible care. Understanding the impact of OST misuse and diversion is key to defining strategies to address these issues.
Oncologic Outcomes according to the Treatment Strategy in Radiologic Complete Responders after Neoadjuvant Chemoradiation for Rectal Cancer
Authors: Lee Soo Young , Kim Chang Hyun , Kim Young Jin , Kim Hyeong Rok
Published: October 2015

Objective: This study aimed to compare the oncologic outcomes between treatment strategies for rectal cancer [radical surgery, local excision (LE), and the wait-and-see approach] in radiologic complete responders after neoadjuvant chemoradiation (nCRT). Methods: We retrospectively reviewed rectal cancer patients and included 52 radiologic complete responders after nCRT defined as no residual tumor or residual fibrosis and no suspicious metastatic lymph nodes on magnetic resonance imaging (MRI). Clinicopathologic features and oncologic outcomes were compared according to the treatment strategies. Results: The median follow-up period was 41 months (range, 6-80). Twenty-eight patients underwent radical surgery, whereas 16 underwent LE, and 8 were closely monitored without initial surgery. The pathologic complete response rate was 40.9%. Patients who underwent radical surgery showed better prognosis compared to those who underwent LE or wait-and-see (3-year disease-free survival: radical surgery 85.0% vs. LE 62.5%, wait-and-see 75.0%, p = 0.019; 3-year local recurrence-free survival: radical surgery 96.4% vs. LE 67.0%, wait-and-see 75.0%, p = 0.009). After recurrence, patients who underwent salvage surgery showed a relatively good oncologic outcome. Conclusion: Pursuing LE or the wait-and-see approach instead of radical surgery in rectal cancer patients undergoing nCRT may bring about a detrimental oncologic outcome if clinical complete response is solely determined by MRI.
Retroperitoneal Schwannoma in the Renal Hilum: A Case Report
Authors: Kumano Yohei , Kawahara Takashi , Chiba Sawako , Maeda Yoko , Ohtaka Mari , Kondo Takuya , Mochizuki Taku , Hattori Yusuke , Teranishi Jun-Ichi , Miyoshi Yasuhide , Yumura Yasushi , Inayama Yoshiaki , Yao Masahiro , Uemura Hiroji
Published: October 2015

A 73-year-old male was referred to our department for further treatment of a right retroperitoneal tumor. Contrast CT showed a tumor mass measuring 33 × 26 mm in size with poor contrast enhancement. Because we were unable to rule out tumor malignancy, we planned an operation. The tumor was easily separated and removed without nephrectomy. Histological study revealed a schwannoma. It is rare for this kind of tumor to arise from the retroperitoneum (approximately 0.7% of all cases), in particular at the renal hilum. We herein report a rare case of retroperitoneal schwannoma arising from the renal hilum.
Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria
Authors: Maurer Marcus , Church Martin K. , Metz Martin , Starkhammar Maria , Hamsten Carl , van Hage Marianne
Published: October 2015

Background: Tick bite-induced galactose-α-1,3-galactose (α-Gal) IgE and subsequent ingestion of red meat may cause delayed severe allergic reactions including urticaria, gastrointestinal symptoms or anaphylaxis. We tested the hypothesis that increased levels of IgE to α-Gal due to tick bites and the subsequent ingestion of red meat or meat products may possibly be an un(der)recognized cause of chronic spontaneous urticaria (CSU). Methods: Levels of IgE to α-Gal and total IgE were measured (ImmunoCAP, Phadia AB/Thermo Fisher Scientific) in 83 patients (61 female and 22 male, median age 43 years, range 18-82) from the Department of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany. All had been clinically diagnosed with moderate-to-severe CSU of a median duration of 2.9 years (range 0.1-50). Results: Eighty of the 83 patients (96%) had undetectable (<0.1 kUA/l) serum levels of IgE against α-Gal. The levels in the remaining 3 were all low (0.25, 0.4 and 3.1 kUA/l). In no patient, including those with measurable serum levels of IgE against α-Gal, was eating red meat associated with the development of symptoms of urticaria. Conclusion: Our results indicate that an allergic response to α-Gal is highly unlikely to be a hitherto unrecognized common cause of CSU.
Plasma Xanthine Oxidase Activity Is Predictive of Cardiovascular Disease in Patients with Chronic Kidney Disease, Independently of Uric Acid Levels
Authors: Gondouin Bertrand , Jourde-Chiche Noemie , Sallee Marion , Dou Laetitia , Cerini Claire , Loundou Anderson , Morange Sophie , Berland Yvon , Burtey Stephane , Brunet Philippe , Guieu Regis , Dussol Bertrand
Published: October 2015

Background: Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. Oxidative stress seems to play a pivotal role in this process, and purine metabolism may be involved in CKD-related oxidative stress. Xanthine oxidase (XO) is an enzyme involved in purine metabolism and is also responsible for the production of reactive oxygen species. Methods: This prospective study aimed to analyze the relation between plasma dosages of molecules involved in redox balance, purine metabolism and cardiovascular events in patients with non-diabetic CKD stages 3-5 or on chronic hemodialysis (HD). CKD (n = 51) and HD (n = 50) patients were compared to matched healthy controls (n = 38) and followed-up for 3 years. Results: Both CKD and HD patients had decreased plasma levels of antioxidants (selenium, zinc, vitamin C). HD patients had decreased levels of the antioxidant enzyme superoxide dismutase and increased levels of oxidation products (ischemia-modified albumin, malondialdehyde [MDA]). The following substrates and enzymes involved in purine metabolism were increased in the HD cohort: adenosine, adenosine deaminase and the pro-oxidant XO. XO activity was negatively correlated with super oxide dismutase and positively with MDA. Interestingly, XO activity was an independent predictor of cardiovascular events in CKD and HD patients, regardless of uric acid levels. Uric acid was not predictive of events. Conclusion: This highlights a possible role of XO itself in CKD-related cardiovascular disease (CVD) and raises the hypothesis that beneficial effects observed with XO inhibitors on CVD in CKD may also be due to the reduction of oxidative stress.
Occurrence of antibodies anti-Toxoplasma gondii and anti-Neospora caninum in dogs from Natal, RN, Brazil
Authors: Lopes Marcos Gomes , Hernandez Maurício , Lima Júlia Tereza Ribeiro de , Grisi Filho José Henrique Hildebrand , Gennari Solange Maria
Published: October 2015

A ocorrência de anticorpos anti-Toxoplasma gondii e anti-Neospora caninum foi determinada em cães do município de Natal, RN, onde informações sobre a presença destes coccídios nessa espécie não era conhecida. Para tanto, foram utilizados 29 cães domiciliados, que habitam áreas que circundam duas importantes Unidades de Conservação de Mata Atlântica presentes no município (Parque da Cidade e Parque das Dunas), e outros 73 cães que foram sacrificados no Centro de Controle de Zoonoses de Natal por serem positivos a Leishmania spp. Somente em relação aos cães que vivem próximos aos parques foi possível a obtenção de informações sobre o sexo dos animais. A presença de anticorpos contra cada um dos coccídios foi determinada com a Reação de Imunofluorescência Indireta com ponto de corte de 16 para T. gondii e 50 para N. caninum. Dos 102 cães examinados, 13 (12,7%, IC 95% 7,0-20,8) foram positivos para T. gondii e 3 (2,9%, IC 0,6-8,4%) para N. caninum. Associação entre: localidades de obtenção das amostras (parques x CCZ) e sexo dos animais com a ocorrência de anticorpos contra cada um dos parasitos, determinada através do teste exato de Fisher, foram positivas para T. gondii, com os machos (p = 0,027) e cães que habitam próximos aos parques (p = 0,008) apresentando maiores taxas de infecção. Associações não foram observadas em relação a N. caninum.
Chemical carcinogenesis by DMBA (7,12-dimethylbenzanthracene) in female BALB/c mice: new facts
Authors: Oliveira Krishna Duro de , Avanzo Gabriela Uliana , Tedardi Marcello Vannucci , Rangel Marcelo Monte Mór , Avanzo José Luis , Fukumasu Heidge , Rao Kurapati Venkata Kesava , Sinhorini Idércio Luiz , Dagli Maria Lúcia Zaidan
Published: October 2015

Hidrocarbonetos policíclicos e aromáticos são carcinógenos usados em modelos experimentais em roedores. Neste estudo, o carcinógeno DMBA (7,12-dimetilbenzantraceno) foi administrado por gavagem, diluído em óleo de milho, para camundongos BALB/c em doses hebdomadárias de 1 mg por animal por 1, 3, 6 ou 9 semanas. Os animais foram pesados e monitorados semanalmente até a morte. Os animais remanescentes foram eutanasiados com a idade de 53 semanas. Na necroscopia, fragmentos representativos das neoplasias foram colhidos e rotineiramente processados para exame histopatológico. De todos os animais que receberam DMBA, 68,57% desenvolveram algum tipo de tumor. Entre os 70 camundongos tratados com diferentes doses de DMBA, 22 (31,43%) desenvolveram neoplasias mamárias. O adenoacantoma foi o tumor mamário mais comumente diagnosticado (18,75%). Pulmões (15,71%), tecido linfoide (11,43%), estômago (7,14%) e pele (2,86%) foram também locais primários de desenvolvimento de neoplasias. Um terço (33,33%) dos camundongos que receberam 1 mg de DMBA desenvolveram neoplasias pulmonares. Portanto, a administração de DMBA foi considerada um modelo eficiente de carcinogênese em camundongos, especialmente para o estudo de neoplasias mamárias, quando a maior dose é utilizada, e de neoplasias pulmonares, quando utilizada a menor dose. Os modelos de carcinogênese química têm sido usados para diversos estudos na pesquisa em câncer, os resultados aqui apresentados mostram novos fatos para um modelo clássico de carcinogênese.
Coatis (Nasua nasua) semen cryopreservation
Authors: Paz Regina Celia Rodrigues da , Avila Heid Belle dos Santos
Published: October 2015

Os procedimentos de criopreservação do sêmen em carnívoros devem ser iniciados após a lavagem e centrifugação em meios de cultura para retirada do plasma seminal e eliminação de microrganismos. O objetivo deste estudo foi realizar a criopreservação do sêmen de quatis comparando os efeitos entre dois extensores Ham’s F-10 e M199 para lavagem e centrifugação do sêmen antes do congelamento com o meio Dilutris. Amostras de sêmen (n = 36) foram coletadas por eletroejaculação em seis quatis (Nasua nasua) machos adultos entre maio e outubro de 2008, no Zoológico da Universidade Federal de Mato Grosso. Motilidade total (%), motilidade espermática progressiva (0-5), integridade da membrana plasmática (%) e integridade do acrossoma (%) foram analisados. Amostras de sêmen a fresco foram divididas em duas frações, diluídas em 1 mL de Ham’s F-10 (Ham’s F-10, Nutricel S.A., Brasil) ou M199 (M199, Nutricel S.A., Brazil) e centrifugado a 300 g por 10 min. O sobrenadante foi descartado e pellets ressuspendidos em 1 mL de Dilutris (Dilutris, Minitube®, Brasil), armazenados a 5ºC durante 3 horas, transferidos para palhetas de 0,25 mL, colocadas em vapor de nitrogênio líquido por 20 min e imersos em nitrogênio líquido. Os resultados para sêmen a fresco e sêmen congelado utilizando Ham’s F-10/Dilutris e M199/Dilutris foram, respectivamente: 84,28 ± 11,57, 45,38 ± 27,26 e 44,61 ± 25,03 para motilidade total; 3,64 ± 1,44, 2,15 ± 1,14 e 2,07 ± 1,03 para a motilidade progressiva; 92,76 ± 3,46, 84,69 ± 15,77 e 89,76 ± 13,97 para integridade da membrana plasmática; e 94,76 ± 2,89, 92,35 ± 4,73 e 90,58 ± 7,17 para integridade do acrossoma. Não houve diferença significativa (P < 0,05) entre os valores obtidos nos tratamentos Ham’s F-10/Dilutris ou M199/Dilutris. Ambos os tratamentos demonstraram ser adequados para a congelação de sêmen desta espécie.
Influência da temperatura de transporte de ovários na maturação in vitro de oócitos caninos coletados em diferentes estágios do ciclo estral
Authors: Pereira Leda Maria Costa , Bersano Paulo Ricardo Oliveira , Lopes Maria Denise
Published: October 2015

Foi avaliada a influencia do ciclo estral e temperatura de transporte de ovários na maturação in vitro de oócitos caninos. As cadelas foram categorizadas em dois grupos baseados no estagio do ciclo estral – anestro ou diestro. Um ovário por par coletado foi transportado em solução fisiológica 0,9% a 4°C enquanto o outro foi transportado a 37°C. Então, os ovários foram seccionados em PBS para a liberação dos complexos cumulus oocito (COCs). Um total de 345 COCs (n = 186 oocitos obtidos de cadelas em anestro e 159 em diestro) foi cultivado em TCM 199 suplementado com HEPES, piruvato de sódio, cisteina, hormônio folículo estimulante (FSH), gonadotrofina coriônica humana (hCG), estrógeno (E2) e fator de crescimento epidermal (EGF). Apos 72h de maturação, os COCs foram desnudados, fixados e corados para avaliação da maturação nuclear. O teste de Fisher foi utilizado para avaliar as diferenças entre os grupos. O nível de significância adotado foi de 0,05. Os oócitos obtidos de cadelas em diestro transportados a 4°C apresentaram maior frequência de oócitos no estagio de metáfase II (21,1%) que os mantidos na temperatura de 37°C (p < 0,01). De forma similar, houve maior frequência de oócitos nos estágios de metáfase II (11,2%) nos ovários obtidos de cadelas em anestro e transportados a 4°C que nos ovários mantidos a 37°C (p < 0,05). Concluiu-se que a temperatura de transporte influencia os resultados de viabilidade oocitária canina e a maturação in vitro, independentemente do estagio reprodutivo da fêmea.
Eficiência placentária na espécie equina: quais fatores podem estar relacionados?
Authors: Guimarães Carina Fatima , Meirelles Marcela Gonçalves , Fernandes Claudia Barbosa
Published: October 2015

Esta revisão de literatura propõe levantar os principais fatores que podem influenciar o crescimento intrauterino e o suprimento de nutrientes placentários para o feto, abordando aspectos morfofuncionais relacionados à eficiência placentária, correlacionando-os com aspectos zootécnicos, como raça, pluriparidade e idade das fêmeas gestantes. O objetivo foi estabelecer as interrelações que determinem maior eficiência placentária, propondo um paralelo comparativo entre espécies a fim de ser entendida a eficiência placentária na espécie equina.
A checklist of longhorn beetles (Coleoptera: Cerambycidae) of Serbia
Authors: ILIĆ NASTAS , ĆURČIĆ SREĆKO
Published: September 2015

A checklist of all taxa of the family Cerambycidae (longhorn beetles) from Serbia is presented. The checklist is based on compilation of data gathered both from authors and available literature published up to now. A total of 265 species and 92 subspecies belonging to 109 genera, 48 tribes, and six subfamilies are recorded for Serbia. However, the presence of 28 species listed in Serbia may be questionable. Known distribution and biology of Serbian taxa are provided. The diversity of the fauna of longhorn beetles in Serbia is compared with the surrounding areas in the Balkan Peninsula.
Description of a new species of Niphargus (Crustacea: Amphipoda:
Niphargidae): the first record of a lake ecomorph in the Carpathian Mountains
Authors: PETKOVIĆ MATIJA , DELIĆ TEO , LUČIĆ LUKA , FIŠER CENE
Published: October 2015

We describe and phylogenetically characterize a new species Niphargus mirocensis from Mt. Miroč, eastern Serbia. This species shows distinct morphology typical for a lake ecomorph of niphargid amphipod, i.e. large and stout body, elongated appendages and raptorial gnathopods and presents the first record of this ecomorph in Carpathian Mountains. Phylogenetic analyses based on Cytochrome Oxidase Subunit 1 gene (COI), Histone (H3) and 28S rRNA (28S) suggests that species is nested within a clade of lake ecomorphs spread in Italy and Central Dinaric Region. The new finding is geographic extension of clade’s range, the species of which are generally narrow endemics.
A new species of Shaanxiana (Lepidoptera: Lycaenidae) from southern China
Authors: HSU YU-FENG
Published: October 2015

Shaanxiana australis sp. nov. (Theclinae: Theclini) is described from southern China, representing a new taxon of the genus and a remarkable known geographical range extension of the genus. The larval host plant of S. australis is unknown, but the most likely candidate is Fraxinus chinensis (Oleaceae), because congeneric Shaanxiana takashimai use Fraxinus spp. as larval hosts, and F. chinensis is known to grow at the type locality of S. australis.
The Cause of Internal Outflow Surges in a High-Resolution Simulation of the 8 May 2003 Oklahoma City Tornadic Supercell
Authors: Schenkman Alexander D. , Xue Ming , Dawson II Daniel T.
Published: October 2015

A high-resolution simulation of the 8 May 2003 Oklahoma tornadic supercell is analyzed to determine the origin of internal outflow surges within the low-level cold pool. The analyzed simulation has 50-m horizontal grid spacing and is quadruply nested within larger, lower-resolution domains that were initialized via three-dimensional variational data assimilation (3DVAR) of radar and other observations. The high-resolution simulation produces two tornadoes that track in close proximity to the observed tornado on 8 May 2003. The authors’ previous study determined that an internal outflow surge instigated tornadogenesis for the first tornado in this simulation but the cause of this internal outflow surge was unclear.

In this study, the vertical momentum equation is analyzed along backward trajectories that are initialized within the tornado-triggering internal outflow surge. The analysis reveals that the internal outflow surge is forced by the dynamic part of the vertical pressure gradient. Further examination reveals that the dynamic forcing is the result of a high pressure perturbation in an area of stagnating flow on the west and northwest sides of the low-level (below ~3 km AGL) mesocyclone. This region of high perturbation pressure is unsteady and forces several other warm internal outflow surges on the west side of the tornado. Cold internal outflow surges also occur later in the simulation and are shown to be buoyantly forced by evaporation and water loading in heavy precipitation.
Using Single-Forcing GCM Simulations to Reconstruct and Interpret Quaternary Climate Change
Authors: Erb Michael P. , Jackson Charles S. , Broccoli Anthony J.
Published: October 2015

The long-term climate variations of the Quaternary were primarily influenced by concurrent changes in Earth’s orbit, greenhouse gases, and ice sheets. However, because climate changes over the coming century will largely be driven by changes in greenhouse gases alone, it is important to better understand the separate contributions of each of these forcings in the past. To investigate this, idealized equilibrium simulations are conducted in which the climate is driven by separate changes in obliquity, precession, CO2, and ice sheets. To test the linearity of past climate change, anomalies from these single-forcing experiments are scaled and summed to compute linear reconstructions of past climate, which are then compared to mid-Holocene and last glacial maximum (LGM) snapshot simulations, where all forcings are applied together, as well as proxy climate records. This comparison shows that much of the climate response may be approximated as a linear response to forcings, while some features, such as modeled changes in sea ice and Atlantic meridional overturning circulation (AMOC), appear to be heavily influenced by nonlinearities. In regions where the linear reconstructions replicate the full-forcing experiments well, this analysis can help identify how each forcing contributes to the climate response. Monsoons at the mid-Holocene respond strongly to precession, while LGM monsoons are heavily influenced by the altered greenhouse gases and ice sheets. Contrary to previous studies, ice sheets produce pronounced tropical cooling at the LGM. Compared to proxy temperature records, the linear reconstructions replicate long-term changes well and also show which climate variations are not easily explained as direct responses to long-term forcings.
The Role of Intermittency in Internal-Wave Shear Dispersion
Authors: Kunze Eric , Sundermeyer Miles A.
Published: October 2015

This paper revisits a long-standing discrepancy between (i) 1–5-km isopycnal diffusivities of O(1) m2 s−1 based on dye spreading and (ii) inferences of O(0.1) m2 s−1 from internal-wave shear dispersion Kh ~ 〈Kz〉〈〉/f2 in several studies in the stratified ocean interior, where 〈Kz〉 is the bulk average diapycnal diffusivity, 〈〉 the finescale shear variance, and f the Coriolis frequency. It is shown that, taking into account (i) the intermittency of shear-driven turbulence, (ii) its lognormality, and (iii) its correlation with unstable finescale near-inertial shear, internal-wave shear dispersion cannot necessarily be discounted based on available information. This result depends on an infrequent occurrence of turbulence bursts, as is observed, and a correlation between diapycnal diffusivity Kz and the off-diagonal vertical strain, or the vertical gradient of horizontal displacement, |χz| = |∫Vz dt|, which is not well known and may vary from region to region. Taking these factors into account, there may be no need to invoke additional submesoscale mixing mechanisms such as vortical-mode stirring or internal-wave Stokes drift to explain the previously reported discrepancies.
The Specialist Discount
Authors: Merluzzi Jennifer , Phillips Damon J.
Published: October 2015

Recent scholarship on the returns to labor market specialization often claims that being specialized is advantageous for job candidates. We argue, in contrast, that a specialist discount may occur in contexts that share three features: strong institutionalized mechanisms, candidate profiles with direct investments that signal their value, and a high supply of focused candidates relative to demand. We then test whether there is a specialist discount for graduating elite MBAs, as it is a labor market that exemplifies these conditions under which we expect specialists to be penalized. Using rich data on two graduating cohorts from a top-tier U.S. business school, we show that elite MBA graduates who established a focused (specialized) market profile of experiences relating to investment banking before and during the program were less likely to receive multiple job offers and were offered less in starting-bonus compensation than similar MBA candidates with no exposure or less-focused exposure to investment banking. Our theory and findings suggest that the oft-documented specialist advantage may be overstated.
Tinnitus Annoyance in Normal-Hearing Individuals
Authors: Kehrle Helga Moura , Sampaio André Luiz Lopes , Granjeiro Ronaldo Campos , de Oliveira Taciana Sarmento , Oliveira Carlos Augusto Costa Pires
Published: October 2015

Objective:

To assess and correlate tinnitus annoyance in normal-hearing patients with auditory brainstem response and with anxiety/depression.

Methods:

A sample of 84 individuals with tinnitus and normal hearing levels (pure-tone thresholds ≤25 dB HL) was compared to a matched control group of 47 normal-hearing individuals without tinnitus. All participants underwent auditory brainstem response testing. Tinnitus annoyance was assessed using the Tinnitus Handicap Inventory and depression and anxiety using the Beck Depression Inventory and Beck Anxiety Inventory, respectively. We compared auditory brainstem response and anxiety/depression symptoms between groups. In the study group, we correlated the degree of tinnitus annoyance with normal/abnormal auditory brainstem response and presence/level of anxiety/depression symptoms.

Results:

All controls had normal auditory brainstem response; 30 patients with tinnitus had abnormal results. Thirty-five patients with tinnitus had depression and 41 anxiety, while only 2 controls had depression and none had anxiety, with a significant between-group difference ( P < .001). Normal/abnormal auditory brainstem response showed no association with tinnitus annoyance, anxiety, or depression. A higher degree of tinnitus annoyance was associated with severity of depression and anxiety.

Conclusions:

Increased tinnitus annoyance was positively correlated with greater severity of anxiety and depression in normal-hearing patients but was unrelated to normal/abnormal auditory brainstem response.
Harnessing the Diaspora
Authors: Leblang David
Published: September 2015

Political rights provided to immigrants by host countries have received much attention in the literature. Less attention, however, has been paid to the extension of extraterritorial rights by home countries. In this article, I focus on a common type of right provided by home countries to their expatriates—the right of dual citizenship. Dual citizenship rights, I argue, help home countries leverage the financial and human resources of their diasporas, encouraging both remittances and return migration. I test this argument using migrant surveys performed in six host countries and find that migrants from homelands that extend dual citizenship are more likely to both remit and express a desire to return home. The micro finding regarding remittances is confirmed using aggregate panel data for a large sample of homelands over the period 1980-2009. The results point to the importance of political rights and policies as extended by the migrant’s homeland.
Sociality and guru-led movements: Interplay of social issues, action and social service
Authors: Pandya Samta P
Published: September 2015

This article discusses the various facets of sociality of guru-led movements in the contemporary social milieu. It argues that sociality is the key to deciphering the numerous manifestations of the guru-led movements within the social domain. Sociality is the essence of tradition, continuity and perpetuation of these movements. This sociality as imagined here is a result of a meta-analysis of the guru-led movements, reflecting on their socio-political frame of reference; visions on society, stratification and ethics; positions on social issues and social service; views on social transformation and tangible social service along with the antagonisms and contradictions which penetrate all the social imaginaries. The analysis builds upon two aspects: the episteme of sociality and the episteme of guru-led movements. In terms of the episteme of sociality there is substantiation of a strong conception of sociality which emphasizes social relations to others. Faith and guru memory are central categories and embedded in this sociality is a potential for change. The sociality of guru-led movements throws light on how their agency and actions emerge. It constitutes the movements’ social imaginings and intersubjectivity, which very often are also coloured by their own dominant forces of hegemony and Hindu nationalism.
When Good Measurement Goes Wrong
Authors: Sabia Joseph J. , Burkhauser Richard V. , Hansen Benjamin
Published: October 2015

Hoffman’s (2015) replication of Sabia, Burkhauser, and Hansen (SBH 2012) suggests that “unlucky” measurement error in low-skilled employment in the Current Population Survey Outgoing Rotation Groups (CPS-ORG) led SBH to produce upwardly biased estimates of the labor demand effects of the 2005 to 2006 New York State minimum wage increase. This study replicates Hoffman’s preferred policy estimates from the full CPS and finds evidence that the parallel trends assumption underlying his difference-in-difference approach is violated. When a synthetic control state with pretreatment employment trends similar to those in New York is constructed, this study estimates a relatively large negative employment elasticity with respect to the minimum wage for low-skilled individuals (–0.5), similar to the estimate SBH obtained using the CPS-ORG (–0.6).
Interpreting the Contours of Self-Defence within the Boundaries of the Rule of Law, the Common Law and Human Rights
Authors: Elliott Catherine
Published: October 2015

The Crime and Courts Act 2013 has amended s. 76 of the Criminal Justice and Immigration Act 2008 on the amount of force a person can use in self-defence. The amended provision poses a dilemma for the courts: it states that only reasonable force can be used by a householder against a trespasser, but adds that force is unreasonable if it is grossly disproportionate. Until now, the courts have treated reasonable force and proportionate force as synonyms. This article suggests that the amended s. 76 should be interpreted to comply with the rule of law, incorporating the idea of equality before the law and legality. The courts should respect the traditional common law concept of reasonableness which is an impartial, objective concept that plays an important role across the whole of the criminal legal system. In addition, the article points out that the Act must be interpreted, where possible, in accordance with the European Convention on Human Rights to avoid the problems that arose with the defence of lawful chastisement.
Joint Enterprise
Authors: Way Sam
Published: October 2015

All forms of secondary liability require justification as an exception to the rule that one should not be held criminally liable for the actions of another. Such a justification is particularly difficult to find for parasitic accessory liability, as distinguished from other forms of joint enterprise. Although the doctrine has significant practical benefits, there remain problems with the same kind of liability being imposed on both principal and secondary offenders. This uniform imposition of liability is the primary problem with the joint enterprise doctrine in its current form, and the importance of the type of liability imposed means that differences in sentence are an inadequate way of accounting for the differences in culpability between principal and secondary offenders.
Simulation–optimization of complex tandem queue systems with reneging and server breakdowns considering budget constraints
Authors: Azadeh Ali , Nasirian Bahareh , Hosseinabadi Farahani Mahdi , Soltanpoor Maryam
Published: October 2015

This paper presents a simulation–optimization model for tandem G/G/K queuing systems with infinite capacity considering reneging and server breakdowns. In this problem, the entities that enter each queue after a certain amount of waiting time renege from the queue. Moreover, each of the servers may break down based on the failure rates and will be repaired immediately according to the repair rates. Owing to the complexity of these systems, the OptQuest approach that combines the scatter search (SS) and tabu search (TS) algorithms is employed to determine the optimal number of servers in each queue according to the capacity of resources as well as budget constraints. The main objective of this optimization is to minimize the total time in the system by keeping the average waiting time in each queue below the allowable waiting time. Finally, 20 distinct samples of tandem G/G/K queuing systems are used to evaluate the validity of the proposed simulation model and the optimization algorithm. To the best of our knowledge, this is the first study that both simulates and optimizes tandem G/G/K queuing systems by simultaneously considering reneging and server breakdowns such that budget constraints are satisfied.
Determinants of Local Governments’ Transparency in Times of Crisis: Evidence From Municipality-Level Panel Data
Authors: Tejedo-Romero Francisca , de Araujo Joaquim Filipe Ferraz Esteves
Published: October 2015

The global financial crisis has had an impact on Local Government forcing it to be more transparent in management of public resources. This article examines theoretically and empirically the determinants of the levels of transparency in Local Governments based on the agency and legitimacy theories. For the purpose of this study, the analysis is based on the Spanish municipalities over a period of 4 years, between 2008 and 2012. Running a random effect panel data model, our results showed that transparency is associated with economic and political factors. Unemployment rate, gender, electoral turnout, and political strength have a significant effect on the level of transparency. For other variables like investment and fiscal pressure, we did not find significant evidence of their effect on the level of transparency. We conclude that the factors that best explain the variation in the level of transparency in the period of crisis are associated with political factors.
Role of Amylin in Type 1 and Type 2 Diabetes
Authors: Hieronymus Laura , Griffin Stacy
Published: October 2015

Purpose

The pathophysiology of diabetes has historically focused on alterations in insulin secretion and function; however, diabetes involves multiple hormonal alterations, including abnormal regulation of amylin. This review discusses the physiologic functions of amylin in glucose homeostasis and the rationale for amylin replacement in type 1 and 2 diabetes. The use of pramlintide, a synthetic amylin analog, is also discussed.

Conclusions

Amylin, formed primarily in pancreatic islet β cells, is cosecreted with insulin in response to caloric intake. Patients with type 1 diabetes have lower baseline amylin serum concentrations, and amylin response to caloric intake is absent. Patients with type 2 diabetes requiring insulin also have a diminished amylin response to caloric intake, potentially related to the degree of β-cell impairment. Key physiologic functions of amylin in maintaining glucose homeostasis include suppressing glucagon release in response to caloric intake, delaying the rate of gastric emptying, and stimulating the satiety center in the brain to limit caloric intake. Pramlintide is indicated for adults with type 1 and 2 diabetes who have not achieved adequate glucose control despite optimal insulin therapy. As an adjunct to insulin therapy, pramlintide demonstrated significant reductions in A1C in patients with type 1 and 2 diabetes, with favorable effects on body weight. It is administered subcutaneously before each major meal. There is an increased risk of hypoglycemia with insulin when used in combination with pramlintide. Other adverse effects may include nausea, vomiting, anorexia, reduced appetite, and headache. Proper patient selection and education are essential to successful pramlintide use.
Grandparent Education Through Simulation-Diabetes
Authors: Maguire Laura L. , Crawford Sybil , Sullivan-Bolyai Susan
Published: October 2015

Purpose

The purpose of this study was to explore the feasibility of using human patient simulation (HPS) to teach type 1 diabetes (T1DM) management to grandparents of grandchildren with T1DM.

Methods

Thirty grandparents (11 male, 19 female) of young grandchildren (aged 12 and under) with T1DM were recruited from an urban medical center. Experimental group (n = 14) grandparents received hands-on visual T1DM management education using an HPS intervention, and control group (n = 16) grandparents received similar education using a non-HPS intervention.

Findings

This study demonstrated the feasibility of recruiting and retaining grandparents into a clinical trial using HPS to teach T1DM management. Post intervention, all grandparent scores for T1DM knowledge, confidence, and fear showed significant improvement from time 1 to time 2, with HPS group grandparent scores showing consistently larger improvement.

Conclusions

The consistency of larger HPS-taught grandparent score improvement is suggestive of a benefit for the HPS teaching method. Early multimethod Certified Diabetes Educator (CDE)–provided T1DM education is an important point of entry for inducting grandparent members onto the grandchild’s diabetes care team.
Diabetes Education as a Career Choice
Authors: Dickinson Jane K. , Lipman Ruth D. , O’Brian Catherine A.
Published: October 2015

Purpose

The purpose of the study was to examine the field of diabetes education along with identifying facilitators and barriers for future health care professionals entering the specialty field of diabetes education.

Method

Faculty members who were currently teaching in a health-related discipline, the students of those faculty members, and nursing students who were members of the National Student Nursing Association were surveyed to gather descriptive data.

Results

While faculty members reported they are promoting diabetes education to their health professions students, many nursing students are not aware of this career path. Nursing students understand that diabetes is a significant problem and will be something they encounter in all areas of their careers, but many were not sure they wanted to specialize in it.

Conclusions

There is a gap between what faculty members and students report as far as awareness of the diabetes education specialty. In addition, misinformation about diabetes and people living with diabetes may be a deterrent for potential future diabetes educators. American Association of Diabetes Educators, health professions faculty members, and practicing diabetes educators can do more to clear up misconceptions and promote diabetes education as a career path for students in the health professions.