bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-exposure Prophylaxis Use and Discontinuation in a Federally Qualified Health Center in a Mexico-US Border City
Authors: Riley Taylor , Anaya Gerardo , Gallegos Patricia A. , Castaneda Rudy , Khosropour Christine M.
Published: October 2023

Background

Latino men who have sex with men (MSM) experience disproportionately high rates of HIV diagnoses in the United States. Pre-exposure prophylaxis (PrEP) use is critical to reduce this inequity, but PrEP awareness, access, and use are low among Latino MSM. This study aims to describe patterns of PrEP persistence and discontinuation among predominately Latino MSM accessing PrEP in a federally qualified health center (FQHC) in El Paso, Texas.

Methods

This retrospective cohort comprised individuals who were eligible for PrEP at a FQHC in El Paso, Texas, between January 30, 2019, and August 15, 2021. We defined hierarchical categories of PrEP use and discontinuation, which was defined as more than 120 days between PrEP visits. We used Kaplan–Meier survival plots to estimate median time to first PrEP discontinuation.

Results

There were 292 patients evaluated for PrEP; 91% were Latino. The majority of PrEP patients (70%, 205/292) experienced any PrEP discontinuation, and the median time to first PrEP discontinuation was 202 days (95% CI: 179–266). The proportion of patients who remained on PrEP at 3 months after initiation was 82% (95% CI: 76%, 87%) and at 6 months after initiation was 55% (95% CI: 46%, 62%).

Conclusion

While 3-month PrEP retention was high in this predominately Latino MSM patient population, PrEP discontinuation was common. Interventions that enhance longer-term persistence and support for restarting PrEP are needed to reduce the persistent ethnoracial disparities in HIV incidence.
A comprehensive review of pedestrian re-identification based on deep learning
Authors: Sun Zhaojie , Wang Xuan , Zhang Youlei , Song Yongchao , Zhao Jindong , Xu Jindong , Yan Weiqing , Lv Cuicui
Published: October 2023

Pedestrian re-identification (re-ID) has gained considerable attention as a challenging research area in smart cities. Its applications span diverse domains, including intelligent transportation, public security, new retail, and the integration of face re-ID technology. The rapid progress in deep learning techniques, coupled with the availability of large-scale pedestrian datasets, has led to remarkable advancements in pedestrian re-ID. In this paper, we begin the study by summarising the key datasets and standard evaluation methodologies for pedestrian re-ID. Second, we look into pedestrian re-ID methods that are based on object re-ID, loss functions, research directions, weakly supervised classification, and various application scenarios. Moreover, we assess and display different re-ID approaches from deep learning perspectives. Finally, several challenges and future directions for pedestrian re-ID development are discussed. By providing a holistic perspective on this topic, this research serves as a valuable resource for researchers and practitioners, enabling further advancements in pedestrian re-ID within smart city environments.
Rethinking Informal Economy Resilience during Crisis: Experience from COVID-19 Pandemic
Authors: Aditya Bagas , Amri Ikhwan
Published: October 2023

The COVID-19 pandemic has disrupted the public health system and socioeconomic sector, one of the worst being the impacts on the informal economy. Despite their past survival, the current pandemic-induced crisis has cast doubt on informal economy resilience. This study aims to capture the informal economy resilience facing the unprecedented economic crisis triggered by the COVID-19 pandemic. We reviewed 42 selected peer-reviewed journal articles to synthesise a general concept of informal economy resilience during pandemic-induced crisis. We found that strict lockdown during a pandemic becomes the main driver that exacerbates the vulnerability of informal economy. The impacts are spatiotemporally varied, different within the group, and have multilevel characteristics (from individual to society). This vulnerable condition has triggered the informal economy to conduct several coping mechanisms to face economic disadvantages. Both individual coping mechanisms and government intervention have altered the informal economy's resilience throughout time. The current combination of defense mechanisms results in four possibilities: bounce back better, bounce back, recover but worsen, and collapse. This review offers valuable insights into the appropriate actions that governments should undertake in response to economic downturns resulting from pandemics. It highlights the importance of considering vulnerable groups when formulating policy during a crisis.
Evolution of Inequality in Nigeria: a Tale of Falling Inequality, Rising Poverty, and Regional Heterogeneity
Authors: Odozi John Chiwuzulum , Uwaifo Oyelere Ruth
Published: October 2023

Recent research on Nigeria indicates declining income inequality. In contrast, anecdotal evidence suggests that only the upper class has benefited from economic growth in Nigeria over time. The disconnect between these findings and anecdotal evidence, and the limitation in how inequality was estimated in the past literature are the motivation for our research. First, we consider if inequality decreased in Nigeria between 2010 and 2018. We then examine how changes in inequality relate to changes in consumption and poverty. In addition, we examine whether there has been convergence in inequality and consumption across geopolitical regions over this period? Leveraging data from the four waves of the Nigeria General Household Panel Survey (GHS) and carefully measuring inequality in consumption expenditure using Gini, our results suggest that between 2010 and 2018, inequality decreased and median consumption expenditure increased. At the same time, poverty incidence and severity increased precipitously. Our findings also suggest convergence across regions over time in estimated within region Gini. In contrast, we find evidence of divergence across regions over time in median households’ consumption.
Surgical Residents´ Results Seem to be Non-Inferior Comparing to More Experienced Surgeons in Femoral Neck Fracture Osteosynthesis
Authors: Forsbacka Nora , Kolari Terhi , Talme Marjo , Bister Ville
Published: October 2023

Purpose of the Study

Femoral neck fracture osteosynthesis is usually performed by using dynamic hip screw (DHS) or multiple parallel cannulated screws (MCS). In orthopedic surgery training, certain hip fractures are one of the most common operations performed by residents. It has been questioned, whether residents can provide as safe treatment and patient outcomes as those of more experienced surgeons. The aim of this study was to evaluate the effect of surgical experience on risk of complications by comparing the surgical performance and clinical outcomes in femoral neck osteosyntheses between surgical residents and orthopaedic surgeons.

Methods

All patients with femoral neck fracture admitted to Helsinki and Uusimaa Hospital District (HUS) Hyvinkää Hospital from 2011 to 2016 were collected as research material. 88 hip fractures (87 patients) treated with DHS or MCS osteosyntheses were included in this study. The patients were divided into 2 groups, based on the surgeon’s experience: an orthopedic surgeon group (n = 68) and a surgical resident group (n = 20). All data from complications, reoperations, and the duration of operations were collected.

Results

There was no significant difference in characteristics of operated patients between orthopaedics and residents group. There was no significant difference in complications or re-operations between groups (p = 0.4, p = 0.2). Surgical residents had statistically longer surgical time (mean 76 min, 95% CI 62.92 min, mean 46 min, 95% Cl 42.51 min; p-value < 0.001). Still surgical time was not a risk factor for complication (p-value 0.5).

Conclusion

Our results show that surgical residents´ outcomes in femoral neck fracture osteosynthesis seem to be as favorable as those of orthopedic surgeons; the operations just last slightly longer.
Adaptability of everyday planning in urban design practices: self-organization and spontaneous action analysis of Galataport, Istanbul
Authors: Korkut Cemre , Nalbantoğlu Oktan
Published: October 2023

Cities are information systems by its social and physical components. The data of these components create a wider picture in urban texture than it was designed by planners and designer in urban practices. The idea of collecting the data and composing models of spontaneous actions in urban simulations can add different dimensions to planning ideas in social terms and spatial texture. The issue is to find out how these components can be better related with each other to let citizens be urban planners as well up to some level, and what level that would be. The aim of the project is to bring back the social impact of the whole city as linking the hubs of Karaköy and Kabataş through the waterfront, also reawakening the collective memory of the port, by preserving the texture of warehouses form Ottoman Empire. The final outcome would be understanding how effectively project would be able to create the dynamics that have been proposed, and whether there have been other spontaneous actions thought the designed area.
Exploring the association between travel demand changes and the built environment during the COVID-19 pandemic
Authors: Mai Zhiyao , He Mingjia , Zhuge Chengxiang , Tang Justin Hayse Chiwing G. , Huang Yuantan , Yang Xiong , Wang Shiqi
Published: October 2023

This study compared the extent to which COVID-19 impacted travel demand of bike-sharing and taxi in New York City, and further explored how the changes in travel demand were associated with the built environment through four typical regression models, namely, least squares (OLS) regression, geographically weighted regression (GWR), temporally weighted regression (TWR), and geographically and temporally weighted regression (GTWR) models. In particular, this study looked at two phases: the lockdown phase (during which travel demand decreased dramatically) and initial recovery phase (during which travel demand started to increase). The results suggested that 1) GTWR performed better than the other three model types; 2) shared bike ridership rebounded much more significantly during the recovery phase than taxi ridership; 3) Commercial Point of Interest (POI) was positively associated with the change of ridership in both lockdown and recovery phases.
Unlocking the sustainability of medium enterprises: A framework for reducing cognitive biases in sustainable performance management
Authors: Cristofaro Matteo , Giardino Pier Luigi , Camilli Riccardo , Hristov Ivo
Published: October 2023

Medium Enterprises (MEs) are significant contributors to global economic development. Integrating sustainability practices in their business can support MEs worldwide to become more sustainable, improving companies’ performance and stakeholders’ expectations. Nevertheless, few MEs adopt sustainable practices. Following Behavioral Decision Theory and Behavioral Strategy literature, we argue that this can be associated with their managers’ decision-making processes – apart from not possessing considerable resources like large companies. Via a mixed-method research design involving 277 Italian ME managers, we investigate the cognitive biases that hinder the development of a sustainable performance management system (SPMS) in MEs. We found the most prominent biases influencing SPMS development. Then, we developed a ‘SPMS de-biasing funnel’ framework. We propose some corrective actions to reduce the impact of the most critical cognitive biases that influence SPMS development, allowing related beneficial potential outcomes.
A Mercantilist Brand: The British East India Company and Madeira Wine, 1756–1834
Authors: Câmara Benedita , Lopes Teresa da Silva , Fredona Robert
Published: October 2023

This study analyzes the long-term power of mercantilist firms and brands in industries characterized by high uncertainty and asset specificity. It contrasts the reputation-building and protection strategies employed in two similar industries in Portugal in the eighteenth and early nineteenth centuries; namely, those of Madeira and Port wine. The Portuguese crown created a collective brand for Port in 1756, the first regional appellation in the world. Madeira wine only received similar protection in the late twentieth century. This study argues that the Madeira wine industry relied on a different type of mercantilist proto-brand—a diffuse and multi-faceted “global” umbrella brand—of the British East India Company, which during its heyday more than rivaled the power of the Portuguese state as a product certifier and endorser.
International law, climate change and the Antarctic Treaty System: re-contemplating governance questions apropos of the mounting challenges
Authors: Madani Zia , Shibata Akiho
Published: October 2023

More than 60 years since it entered into force in 1961, the Antarctic Treaty is experiencing significant challenges. These challenges also affect its associated instruments known as the Antarctic Treaty System (ATS). These are mostly external dynamics that are increasingly challenging the ATS from outside of the Antarctic region. They encompass a spectrum of issues relating to global legal regimes and to what extent they are applicable in the Antarctic context. Climate change appears to be the most significant of these challenges, as the tangible planetary impacts of global warming and the perception of its urgency and seriousness by states have prompted additional challenges to the ATS. The physical changes that continue to be scientifically unveiled in the Antarctic are manifesting severe impacts on a planetary scale, and this fact has underscored the need for broader and more rapid international engagement within the Antarctic governance discourse. Nevertheless, the existing decision-making mechanisms compounded by the adversarial atmosphere within the ATS due to external factors have become challenges of themselves. Such challenges call for the re-contemplation and reassessment of the legal regime of the Antarctic in general, and the ATS in particular, to find ways forward for an otherwise historically effective international legal system. This paper utilizes both scientific and legal lenses to underscore the urgent need to achieve better communication between the ATS generally, the Antarctic Treaty Consultative Meetings specifically and the UN Framework Convention on Climate Change and Intergovernmental Panel on Climate Change regimes and to overcome the multiple barriers that stand in the way of achieving that objective.
Casteist demons and working-class prophets: subaltern Islam in Bengal, circa 1872–1928
Authors: Uddin Layli
Published: October 2023

This article investigates the relationship between caste and Islam in Bengal at a time when they acquired heightened significance as markers of identity for the colonial state and between communities. Scholarship, mainly drawing on North India, has emphasised the contrast between the existence in practice of a hierarchical system of social stratification among Muslims and the ideals and traditions of Islamic egalitarianism. This article, however, shows that caste-based struggles and tensions produced a revolutionary Islam. I suggest that the subversive potential of Islamic egalitarianism, described in early Islam by Louise Marlow, was kept alive by low-caste Bengali Muslims. The social reality of caste enabled multiple understandings of what it meant to be a Muslim, and the more radical among them were subaltern ontologies—different meanings of what it was to be a Muslim in the world. Here, I analyse writings on caste by four unreliable narrators around the turn of the twentieth century—a British colonial ethnographer, an ashrāfī Muslim anthropologist, and two Muslim reformers—to describe the politics and lifeworlds of low-caste Muslim groups in Bengal. The article argues for a more nuanced understanding of this period of Islamic reform and development, one that is conscious of the subaltern currents shaping its course. I show how a reformist politics of ‘rejection’ of elite Islam emerged as a response to the problem of caste inequality. These discourses and practices repudiating elite Muslim titles, centring histories of labour, and emphasising equality as an embodied experience reveal the revolutionary potentialities of a subaltern Islam.
New method based on genetic algorithm and Minkowski fractal for multiband antenna designs
Authors: Ezzahry Bouchra , Elhamadi Taj-Eddin , Lamsalli Mohammed , Touhami Naima Amar
Published: October 2023

In this paper, a new method based on a genetic algorithm and Minkowski Island fractal is proposed for multiband antennas. Three-antenna configurations are chosen to validate the proposed optimization procedure. The first configuration is a wide-band antenna, operating in the WLAN (wireless local area network) UNII-2C band. The second configuration is a dual-band antenna, operating in the WLAN UNII-2 and UNII-2C bands. In contrast, the third is a tri-band antenna operating in the UNII-2, UNII-2C, and UNII-3 bands. The optimization process is accelerated by using the Computer Simulation Technology (CST) Application Programming Interface which allows all genetic operators to be performed in MATLAB while the numerical calculations are running in the internal CST Finite-Difference Time-Domain -solver using parallel computing with GPU acceleration. All three designed configurations are manufactured using a $\textstyle0.8\;\text{mm}$ thick FR4 epoxy substrate with a relative dielectric constant of $4.8$. The return loss and the radiation pattern’s measurements agree well with the simulation results. Further, the methodology presented can be very effective in terms of size reduction; the designed antennas are $24 \times 24 \times 0.8\;{\textrm{m}}{{\textrm{m}}^3}$ ($460\;{\textrm{m}}{{\textrm{m}}^3}$).
Alleviated WRF Summer Wet Bias Over the Tibetan Plateau Using a New Cloud Macrophysics Scheme
Authors: Zhao Dingchi , Lin Yanluan , Dong Wenhao , Qin Yi , Chu Wenchao , Yang Kun , Letu Husi , Huang Lei
Published: October 2023

Reliable precipitation simulation over the Tibetan Plateau (TP) remains a challenge, manifested by a prominent systematic wet bias in the warm season. Previous studies have generally neglected the potential linkage between surface radiation energy budget and precipitation bias. Prevalent scattered cumulus and thunderstorms over the TP in summer strongly influence surface radiation. A cloud fraction scheme considering subgrid temperature and humidity fluctuations is implemented in the WRF model and tested for a month‐long simulation. It is found that the scheme better reproduces the surface solar radiation compared to a default cloud fraction scheme in the WRF model. Using abundant surface observations, we find that overestimation of the downward surface shortwave radiation (DSSR) would lead to wet bias. DSSR overestimation contributes to higher surface temperature and larger evaporation and enhanced atmospheric instability, which favor more simulated convective precipitation. The study suggests that a better simulation of clouds and surface radiation would benefit precipitation simulation over the plateau.
Voxelated opto-physically unclonable functions via irreplicable wrinkles
Authors: Kim Kitae , Kim Se-Um , Choi Moon-Young , Saeed Mohsin Hassan , Kim Youngmin , Na Jun-Hee
Published: October 2023

The increased prevalence of the Internet of Things (IoT) and the integration of digital technology into our daily lives have given rise to heightened security risks and the need for more robust security measures. In response to these challenges, physical unclonable functions (PUFs) have emerged as promising solution, offering a highly secure method to generate unpredictable and unique random digital values by leveraging inherent physical characteristics. However, traditional PUFs implementations often require complex hardware and circuitry, which can add to the cost and complexity of the system. We present a novel approach using a random wrinkles PUF (rw-PUF) based on an optically anisotropic, facile, simple, and cost-effective material. These wrinkles contain randomly oriented liquid crystal molecules, resulting in a two-dimensional retardation map corresponding to a complex birefringence pattern. Additionally, our proposed technique allows for customization based on specific requirements using a spatial light modulator, enabling fast fabrication. The random wrinkles PUF has the capability to store multiple data sets within a single PUF without the need for physical alterations. Furthermore, we introduce a concept called ‘polyhedron authentication,’ which utilizes three-dimensional information storage in a voxelated random wrinkles PUF. This approach demonstrates the feasibility of implementing high-level security technology by leveraging the unique properties of the rw-PUF.
Long-term effects of prenatal infection on the human brain: a prospective multimodal neuroimaging study
Authors: Suleri Anna , Cecil Charlotte , Rommel Anna-Sophie , Hillegers Manon , White Tonya , de Witte Lot D. , Muetzel Ryan L. , Bergink Veerle
Published: October 2023

There is convincing evidence from rodent studies suggesting that prenatal infections affect the offspring’s brain, but evidence in humans is limited. Here, we assessed the occurrence of common infections during each trimester of pregnancy and examined associations with brain outcomes in adolescent offspring. Our study was embedded in the Generation R Study, a large-scale sociodemographically diverse prospective birth cohort. We included 1094 mother-child dyads and investigated brain morphology (structural MRI), white matter microstructure (DTI), and functional connectivity (functional MRI), as outcomes at the age of 14. We focused on both global and focal regions. To define prenatal infections, we composed a score based on the number and type of infections during each trimester of pregnancy. Models were adjusted for several confounders. We found that prenatal infection was negatively associated with cerebral white matter volume (B = −0.069, 95% CI −0.123 to −0.015, p = 0.011), and we found an association between higher prenatal infection scores and smaller volumes of several frontotemporal regions of the brain. After multiple testing correction, we only observed an association between prenatal infections and the caudal anterior cingulate volume (B = −0.104, 95% CI −0.164 to −0.045, p < 0.001). We did not observe effects of prenatal infection on other measures of adolescent brain morphology, white matter microstructure, or functional connectivity, which is reassuring. Our results show potential regions of interest in the brain for future studies; data on the effect of severe prenatal infections on the offspring’s brain in humans are needed.
Effects of vortioxetine on hippocampal-related cognitive impairment induced in rats by androgen deprivation as a model of prostate cancer treatment
Authors: Vaiana Alexandra M. , Chen Yidong , Gelfond Jonathan , Johnson-Pais Teresa L. , Leach Robin J. , Ramamurthy Chethan , Thompson Ian M. , Morilak David A.
Published: October 2023

Advances in prostate cancer treatment have significantly improved survival, but quality of life for survivors remains an under-studied area of research. Androgen deprivation therapy (ADT) is a foundational treatment for advanced prostate cancer and is used as an adjuvant for prolonged periods in many high-risk, localized tumors. More than half of patients treated with ADT experience debilitating cognitive impairments in domains such as spatial learning and working memory. In this study, we investigated the effects of androgen deprivation on hippocampal-mediated cognition in rats. Vortioxetine, a multimodal antidepressant, has been shown to improve cognition in depressed patients. Thus, we also tested the potential efficacy of vortioxetine in restoring impaired cognition after ADT. We further investigated mechanisms that might contribute to these effects, measuring changes in the circuitry and gene expression within the dorsal hippocampus. ADT via surgical castration induced impairments in visuospatial cognition on the novel object location test and attenuated afferent-evoked local field potentials recorded in the CA1 region of the dorsal hippocampus. Chronic dietary administration of vortioxetine effectively reversed these deficits. Castration significantly altered gene expression in the hippocampus, whereas vortioxetine had little effect. Pathway analysis revealed that androgen depletion altered pathways related to synaptic plasticity. These results suggest that the hippocampus may be vulnerable to ADT, contributing to cognitive impairment in prostate cancer patients. Further, vortioxetine may be a candidate to improve cognition in patients who experience cognitive decline after androgen deprivation therapy for prostate cancer and may do so by restoring molecular and circuit-level plasticity-related mechanisms compromised by ADT.
PLK1 maintains DNA methylation and cell viability by regulating phosphorylation-dependent UHRF1 protein stability
Authors: Peng Yuchong , Liu Youhong , Zheng Rirong , Ye Yubing , Fu Yongming , Yin Linglong , Gao Yingxue , Fu Yuxin , Qi Xuli , Deng Tanggang , Zhang Songwei , Li Xiong
Published: October 2023

PLK1 is a key serine/threonine kinase as well as a master mitotic regulator, but it has never been reported that PLK1 regulates DNA methylation. In the present study, we for the first time found that PLK1 inhibition disrupted global DNA methylation and elevated the expression level of tumor suppressor genes. Mechanistically, we found that PLK1 interacts UHRF1 protein to induce its phosphorylation at serine 265. Phosphorylation is required for the maintenance of UHRF1 protein stability by recruiting a deubiquitinase USP7. Conversely, PLK1 inhibition decreases UHRF1 protein interaction with USP7 and activates the ubiquitin-proteasome pathway, thereby accelerating UHRF1 protein degradation. UHRF1 degradation decreases the recruitment of DNMT1 to chromatin, and decreases the level of genome-wide DNA methylation, thereby elevating the expression of tumor suppressor genes and decreasing cell viability. We here presented the first report on the novel role of PLK1 in DNA methylation maintenance through UHRF1-DNMT1 pathway, and revealed a novel anticancer mechanism of PLK1 inhibitors.
Uncovering the complex relationship between balding, testosterone and skin cancers in men
Authors: Ong Jue-Sheng , Seviiri Mathias , Dusingize Jean Claude , Wu Yeda , Han Xikun , Shi Jianxin , Olsen Catherine M. , Neale Rachel E. , Thompson John F. , Saw Robyn P. M. , Shannon Kerwin F. , Mann Graham J. , Martin Nicholas G. , Medland Sarah E. , Gordon Scott D. , Scolyer Richard A. , Long Georgina V. , Iles Mark M. , Landi Maria Teresa , Whiteman David C. , MacGregor Stuart , Law Matthew H.
Published: October 2023

Male-pattern baldness (MPB) is related to dysregulation of androgens such as testosterone. A previously observed relationship between MPB and skin cancer may be due to greater exposure to ultraviolet radiation or indicate a role for androgenic pathways in the pathogenesis of skin cancers. We dissected this relationship via Mendelian randomization (MR) analyses, using genetic data from recent male-only meta-analyses of cutaneous melanoma (12,232 cases; 20,566 controls) and keratinocyte cancers (KCs) (up to 17,512 cases; >100,000 controls), followed by stratified MR analysis by body-sites. We found strong associations between MPB and the risk of KC, but not with androgens, and multivariable models revealed that this relationship was heavily confounded by MPB single nucleotide polymorphisms involved in pigmentation pathways. Site-stratified MR analyses revealed strong associations between MPB with head and neck squamous cell carcinoma and melanoma, suggesting that sun exposure on the scalp, rather than androgens, is the main driver. Men with less hair covering likely explains, at least in part, the higher incidence of melanoma in men residing in countries with high ambient UV.
The evolution of same-sex sexual behaviour in mammals
Authors: Gómez José M. , Gónzalez-Megías A. , Verdú M.
Published: October 2023

Same-sex sexual behaviour has attracted the attention of many scientists working in disparate areas, from sociology and psychology to behavioural and evolutionary biology. Since it does not contribute directly to reproduction, same-sex sexual behaviour is considered an evolutionary conundrum. Here, using phylogenetic analyses, we explore the evolution of same-sex sexual behaviour in mammals. According to currently available data, this behaviour is not randomly distributed across mammal lineages, but tends to be particularly prevalent in some clades, especially primates. Ancestral reconstruction suggests that same-sex sexual behaviour may have evolved multiple times, with its appearance being a recent phenomenon in most mammalian lineages. Our phylogenetically informed analyses testing for associations between same-sex sexual behaviour and other species characteristics suggest that it may play an adaptive role in maintaining social relationships and mitigating conflict.
Drifting discrete Jovian radio bursts reveal acceleration processes related to Ganymede and the main aurora
Authors: Mauduit Emilie , Zarka Philippe , Lamy Laurent , Hess Sébastien L. G.
Published: October 2023

Radio detection at high time-frequency resolutions is a powerful means of remotely studying electron acceleration processes. Radio bursts have characteristics (polarization, drift, periodicity) making them easier to detect than slowly variable emissions. They are not uncommon in solar system planetary magnetospheres, the powerful Jovian “short bursts (S-bursts)" induced by the Io-Jupiter interaction being especially well-documented. Here we present a detection method of drifting radio bursts in terabytes of high resolution time-frequency data, applied to one month of ground-based Jupiter observations. Beyond the expected Io-Jupiter S-bursts, we find decameter S-bursts related to the Ganymede-Jupiter interaction and the main Jovian aurora, revealing ubiquitous Alfvénic electron acceleration in Jupiter’s high-latitude regions. Our observations show accelerated electron energies are distributed in two populations, kilo-electron-Volts and hundreds of electron-Volts. This detection technique may help characterizing inaccessible astrophysical sources such as exoplanets.
Controlling piezoresistance in single molecules through the isomerisation of bullvalenes
Authors: Reimers Jeffrey R. , Li Tiexin , Birvé André P. , Yang Likun , Aragonès Albert C. , Fallon Thomas , Kosov Daniel S. , Darwish Nadim
Published: October 2023

Nanoscale electro-mechanical systems (NEMS) displaying piezoresistance offer unique measurement opportunities at the sub-cellular level, in detectors and sensors, and in emerging generations of integrated electronic devices. Here, we show a single-molecule NEMS piezoresistor that operates utilising constitutional and conformational isomerisation of individual diaryl-bullvalene molecules and can be switched at 850 Hz. Observations are made using scanning tunnelling microscopy break junction (STMBJ) techniques to characterise piezoresistance, combined with blinking (current-time) experiments that follow single-molecule reactions in real time. A kinetic Monte Carlo methodology (KMC) is developed to simulate isomerisation on the experimental timescale, parameterised using density-functional theory (DFT) combined with non-equilibrium Green’s function (NEGF) calculations. Results indicate that piezoresistance is controlled by both constitutional and conformational isomerisation, occurring at rates that are either fast (equilibrium) or slow (non-equilibrium) compared to the experimental timescale. Two different types of STMBJ traces are observed, one typical of traditional experiments that are interpreted in terms of intramolecular isomerisation occurring on stable tipped-shaped metal-contact junctions, and another attributed to arise from junction‒interface restructuring induced by bullvalene isomerisation.
Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy
Authors: Hedaya Omar M. , Venkata Subbaiah Kadiam C. , Jiang Feng , Xie Li Huitong , Wu Jiangbin , Khor Eng-Soon , Zhu Mingyi , Mathews David H. , Proschel Chris , Yao Peng
Published: October 2023

Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we data-mined human and mouse heart ribosome profiling analyses and identified a double-stranded RNA (dsRNA) structure within the GATA4 uORF that cooperates with the start codon to augment uORF translation and inhibits mORF translation. A trans-acting RNA helicase DDX3X inhibits the GATA4 uORF-dsRNA activity and modulates the translational balance of uORF and mORF. Antisense oligonucleotides (ASOs) that disrupt this dsRNA structure promote mORF translation, while ASOs that base-pair immediately downstream (i.e., forming a bimolecular double-stranded region) of either the uORF or mORF start codon enhance uORF or mORF translation, respectively. Human cardiomyocytes and mice treated with a uORF-enhancing ASO showed reduced cardiac GATA4 protein levels and increased resistance to cardiomyocyte hypertrophy. We further show the broad utility of uORF-dsRNA- or mORF-targeting ASO to regulate mORF translation for other mRNAs. This work demonstrates that the uORF-dsRNA element regulates the translation of multiple mRNAs as a generalizable translational control mechanism. Moreover, we develop a valuable strategy to alter protein expression and cellular phenotypes by targeting or generating dsRNA downstream of a uORF or mORF start codon.
Constructing asymmetric double-atomic sites for synergistic catalysis of electrochemical CO2 reduction
Authors: Jiao Jiqing , Yuan Qing , Tan Meijie , Han Xiaoqian , Gao Mingbin , Zhang Chao , Yang Xuan , Shi Zhaolin , Ma Yanbin , Xiao Hai , Zhang Jiangwei , Lu Tongbu
Published: October 2023

Elucidating the synergistic catalytic mechanism between multiple active centers is of great significance for heterogeneous catalysis; however, finding the corresponding experimental evidence remains challenging owing to the complexity of catalyst structures and interface environment. Here we construct an asymmetric TeN2–CuN3 double-atomic site catalyst, which is analyzed via full-range synchrotron pair distribution function. In electrochemical CO2 reduction, the catalyst features a synergistic mechanism with the double-atomic site activating two key molecules: operando spectroscopy confirms that the Te center activates CO2, and the Cu center helps to dissociate H2O. The experimental and theoretical results reveal that the TeN2–CuN3 could cooperatively lower the energy barriers for the rate-determining step, promoting proton transfer kinetics. Therefore, the TeN2–CuN3 displays a broad potential range with high CO selectivity, improved kinetics and good stability. This work presents synthesis and characterization strategies for double-atomic site catalysts, and experimentally unveils the underpinning mechanism of synergistic catalysis.
Radiolytically reworked Archean organic matter in a habitable deep ancient high-temperature brine
Authors: Nisson Devan M. , Walters Clifford C. , Chacón-Patiño Martha L. , Weisbrod Chad R. , Kieft Thomas L. , Sherwood Lollar Barbara , Warr Oliver , Castillo Julio , Perl Scott M. , Cason Errol D. , Freifeld Barry M. , Onstott Tullis C.
Published: October 2023

Investigations of abiotic and biotic contributions to dissolved organic carbon (DOC) are required to constrain microbial habitability in continental subsurface fluids. Here we investigate a large (101–283 mg C/L) DOC pool in an ancient (>1Ga), high temperature (45–55 °C), low biomass (102−104 cells/mL), and deep (3.2 km) brine from an uranium-enriched South African gold mine. Excitation-emission matrices (EEMs), negative electrospray ionization (–ESI) 21 tesla Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS), and amino acid analyses suggest the brine DOC is primarily radiolytically oxidized kerogen-rich shales or reefs, methane and ethane, with trace amounts of C3–C6 hydrocarbons and organic sulfides. δ2H and δ13C of C1–C3 hydrocarbons are consistent with abiotic origins. These findings suggest water-rock processes control redox and C cycling, helping support a meagre, slow biosphere over geologic time. A radiolytic-driven, habitable brine may signal similar settings are good targets in the search for life beyond Earth.
Realization of an inherent time crystal in a dissipative many-body system
Authors: Chen Yu-Hui , Zhang Xiangdong
Published: October 2023

Time crystals are many-body states that spontaneously break translation symmetry in time the way that ordinary crystals do in space. While experimental observations have confirmed the existence of discrete or continuous time crystals, these realizations have relied on the utilization of periodic forces or effective modulation through cavity feedback. The original proposal for time crystals is that they would represent self-sustained motions without any external periodicity, but realizing such purely self-generated behavior has not yet been achieved. Here, we provide theoretical and experimental evidence that many-body interactions can give rise to an inherent time crystalline phase. Following a calculation that shows an ensemble of pumped four-level atoms can spontaneously break continuous time translation symmetry, we observe periodic motions in an erbium-doped solid. The inherent time crystal produced by our experiment is self-protected by many-body interactions and has a measured coherence time beyond that of individual erbium ions.
Versatile bubble maneuvering on photopyroelectric slippery surfaces
Authors: Zhan Haiyang , Yuan Zichao , Li Yu , Zhang Liang , Liang Hui , Zhao Yuhui , Wang Zhiguo , Zhao Lei , Feng Shile , Liu Yahua
Published: October 2023

Contactless bubble manipulation with a high spatiotemporal resolution brings a qualitative leap forward in a variety of applications. Despite considerable advances, light-induced bubble maneuvering remains challenging in terms of robust transportation, splitting and detachment. Here, a photopyroelectric slippery surface (PESS) with a sandwich structure is constructed to achieve the versatile bubble manipulation. Due to the generated dielectric wetting and nonuniform electric field under the irradiation of near infrared (NIR) light, a bubble is subject to both the Laplace force and dielectrophoresis force, enabling a high-efficiency bubble steering. We demonstrate that the splitting, merging and detachment of underwater bubbles can be achieved with high flexibility and precision, high velocity and agile direction maneuverability. We further extend the capability of bubble control to microrobots for cargo transportation, micropart assembly and transmission of gear structures. We envision this robust bubble manipulation strategy on the PESS would provide a valuable platform for various bubble-involved processes, ranging from microfluidic devices to soft robotics.
Electro-capillary peeling of thin films
Authors: Li Peiliu , Huang Xianfu , Zhao Ya-Pu
Published: October 2023

Thin films are widely-used functional materials that have attracted much interest in academic and industrial applications. With thin films becoming micro/nanoscale, developing a simple and nondestructive peeling method for transferring and reusing the films remains a major challenge. Here, we develop an electro-capillary peeling strategy that achieves thin film detachment by driving liquid to percolate and spread into the bonding layer under electric fields, immensely reducing the deformation and strain of the film compared with traditional methods (reaching 86%). Our approach is evaluated via various applied voltages and films, showing active control characterizations and being appropriate for a broad range of films. Theoretically, electro-capillary peeling is achieved by utilizing the Maxwell stress to compete with the film’s adhesion stress and tension stress. This work shows the great potential of the electro-capillary peeling method to provide a simple way to transfer films and facilitates valid avenues for reusing soft materials.
Transmission-type photonic doping for high-efficiency epsilon-near-zero supercoupling
Authors: Yan Wendi , Zhou Ziheng , Li Hao , Li Yue
Published: October 2023

Supercoupling effect is an exotic and counterintuitive physical phenomenon of epsilon-near-zero (ENZ) media, in which the light can be “squeezed” and tunneled through flexible channels substantially narrower than its wavelength. Theoretically, ENZ channels with infinitely small widths perform ideal supercoupling with full energy transmission and zero-phase advance. As a feasible solution to demonstrate ENZ supercoupling through a finite-width channel, photonic doping can assist the light in squeezing, but the resonant dopant introduces inevitable losses. Here, we propose an approach of transmission-type photonic doping to achieve proximate ideal ENZ supercoupling. In contrast to the conventional resonance-type photonic doping, our proposed transmission-type doping replaces high-quality-factor two-dimensional resonant doping modes with low-quality-factor one-dimensional modes, such that obviously high transmission efficiency and zero-phase advance in ENZ supercoupling is achieved and observed in experiments. Benefiting from the high-efficiency ENZ supercoupling, waveguides with near-total energy transmission can be engineered with arbitrary dimensions and shapes, serving as flexible power conduits in the paradigm of waveguide integrated circuits for future millimeter-wave and terahertz integrated circuit innovations.
Facet-engineered TiO2 drives photocatalytic activity and stability of supported noble metal clusters during H2 evolution
Authors: Chen Yufen , Soler Lluís , Cazorla Claudio , Oliveras Jana , Bastús Neus G. , Puntes Víctor F. , Llorca Jordi
Published: October 2023

Metal clusters supported on TiO2 are widely used in many photocatalytic applications, including pollution control and production of solar fuels. Besides high photoactivity, stability during the photoreaction is another essential quality of high-performance photocatalysts, however systematic studies on this attribute are absent for metal clusters supported on TiO2. Here we have studied, both experimentally and with first-principles simulation methods, the stability of Pt, Pd and Au clusters prepared by ball milling on nanoshaped anatase nanoparticles preferentially exposing {001} (plates) and {101} (bipyramids) facets during the photogeneration of hydrogen. It is found that Pt/TiO2 exhibits superior stability than Pd/TiO2 and Au/TiO2, and that {001} facet-based photocatalysts always are more stable than their {101} analogous regardless of the considered metal species. The loss of stability associated with cluster sintering, which is facilitated by the transfer of photoexcited carriers from the metal species to the neighbouring Ti and O atoms, most significantly and detrimentally affects the H2-evolution photoactivity.
CRAWLING: a crowdsourcing algorithm on wheels for smart parking
Authors: Garrabé Émiland , Russo Giovanni
Published: October 2023

We present the principled design of CRAWLING: a CRowdsourcing Algorithm on WheeLs for smart parkING. CRAWLING is an in-car service for the routing of connected cars. Specifically, cars equipped with our service are able to crowdsource data from third-parties, including other cars, pedestrians, smart sensors and social media, in order to fulfill a given routing task. CRAWLING relies on a solid control-theoretical formulation and the routes it computes are the solution of an optimal data-driven control problem where cars maximize a reward capturing environmental conditions while tracking some desired behavior. A key feature of our service is that it allows to consider stochastic behaviors, while taking into account streams of heterogeneous data. We propose a stand-alone, general-purpose, architecture of CRAWLING and we show its effectiveness on a set of scenarios aimed at illustrating all the key features of our service. Simulations show that, when cars are equipped with CRAWLING, the service effectively orchestrates the vehicles, making them able to react online to road conditions, minimizing their cost functions. The architecture implementing our service is openly available and modular with the supporting code enabling researchers to build on CRAWLING and to replicate the numerical results.
Deleterious mutations predicted in the sorghum (Sorghum bicolor) Maturity (Ma) and Dwarf (Dw) genes from whole-genome resequencing
Authors: Grant Nathan P. , Toy John J. , Funnell-Harris Deanna L. , Sattler Scott E.
Published: October 2023

In sorghum [Sorghum bicolor (L.) Moench] the Maturity (Ma1, Ma2, Ma3, Ma4, Ma5, Ma6) and Dwarf (Dw1, Dw2, Dw3, Dw4) loci, encode genes controlling flowering time and plant height, respectively, which are critical for designing sorghum ideotypes for a maturity timeframe and a harvest method. Publicly available whole-genome resequencing data from 860 sorghum accessions was analyzed in silico to identify genomic variants at 8 of these loci (Ma1, Ma2, Ma3, Ma5, Ma6, Dw1, Dw2, Dw3) to identify novel loss of function alleles and previously characterized ones in sorghum germplasm. From ~ 33 million SNPs and ~ 4.4 million InDels, 1445 gene variants were identified within these 8 genes then evaluated for predicted effect on the corresponding encoded proteins, which included newly identified mutations (4 nonsense, 15 frameshift, 28 missense). Likewise, most accessions analyzed contained predicted loss of function alleles (425 ma1, 22 ma2, 40 ma3, 74 ma5, 414 ma6, 289 dw1, 268 dw2 and 45 dw3) at multiple loci, but 146 and 463 accessions had no predicted ma or dw mutant alleles, respectively. The ma and dw alleles within these sorghum accessions represent a valuable source for manipulating flowering time and plant height to develop the full range of sorghum types: grain, sweet and forage/biomass.
Inhibition of IL-17 ameliorates keratinocyte-borne cytokine responses in an in vitro model for house-dust-mite triggered atopic dermatitis
Authors: Haertlé Juliane , Kienlin Petra , Begemann Gabriele , Werfel Thomas , Roesner Lennart M.
Published: October 2023

A subgroup of patients suffering from atopic dermatitis (AD) does not respond to biologics therapy targeting the key players of type-2 inflammation, and it is an ongoing discussion whether skin-infiltrating Th17 cells may underlie this phenomenon. This study aimed to investigate the potential of allergen-induced, immune-cell derived IL-17 on the induction of inflammatory processes in keratinocytes. Peripheral blood mononuclear cells derived from respectively sensitized AD patients were stimulated with house dust mite (HDM) extract and cell culture supernatants were applied subsequently in absence or presence of secukinumab to primary human keratinocytes. Hereby we confirm that the immune response of sensitized AD patients to HDM contains aside from type-2 cytokines significant amounts of IL-17. Blocking IL-17 efficiently reduced the stimulation-induced changes in keratinocyte gene expression. IL-17-dependent transcriptional changes included increased expression of the cytokines IL-20 and IL-24 as well as Suppressor of Cytokine Siganling 3 (SOCS3), a negative feedback-regulator of the STAT3/IL-17/IL-24 immune response. We conclude that the immune response to HDM can induce pro-inflammatory cytokines from keratinocytes in AD, which in part is mediated via IL-17. Targeting IL-17 may turn out to be a reasonable alternative therapy in a subgroup of patients with moderate to severe AD and HDM sensitization.