bluuebunny/crossref_metadata_2025 huggingface dataset:
Clustering Optimization Algorithm for Data Mining Based on Artificial Intelligence Neural Network
Authors: Zhang Shuyue , Duan Chao
Published: February 2022

Social production and life have become increasingly prominent. Cluster analysis is the basis for further processing of the data. The concept of data mining and the application of neural networks in data mining are introduced. According to the related technology of data mining, this article introduces in detail the two-layer perceptron, backpropagation (BP) neural network, RBF radial basis function network for processing classification problems, and self-organizing map (SOM) self-organizing neural network for unsupervised clustering problems. According to the characteristics of self-adaptive and self-organizing capabilities of these algorithms, we learn and design and implement data mining clustering optimization algorithms. In this paper, the neural network-based data mining process consists of three stages: data preparation, rule extraction, and rule evaluation. This paper studies the teaching-type and decomposition-type rule extraction algorithms. After analyzing the BP decomposition-type algorithm, the correlation method is used to calculate the correlation of the input and output neurons. After sorting by the degree of correlation, the RBF neural network is used for node selection. This can greatly reduce the number of input nodes of the neural network, simplify the network structure, reduce the number of recursive splits of the subnet, and improve calculation efficiency. Taking the model as an example, the training error is calculated through data mining technology and clustering algorithm. Data mining clustering optimization algorithm mainly improves the popular neural network from two aspects: finer model design and model pruning, and simulates model complexity, computational complexity, and errors through simulation experiments. The rate is measured, and finally, the simulation experiment is performed. The results show that the proposed algorithm for differential distributed data mining has higher accuracy and stronger convergence ability and overcomes the shortcomings and shortcomings of several original genetic algorithm optimization neural network data mining models; it can effectively improve the searchability and search accuracy of the algorithm and improve the efficiency of data mining. Accuracy and accuracy have a wide range of applications.
Ai-Tong-An-Gao-Ji and Fisetin Inhibit Tumor Cell Growth in Rat CIBP Models by Inhibiting the AKT/HIF-1α Signaling Pathway
Authors: Wang Jing , Lai Zonglang , Zhou Xin , Na Song , Zhang Liufan , Cheng Jun
Published: February 2022

Background. Ai-Tong-An-Gao-Ji (ATAGJ) has been extensively applied for acute bone cancer pain treatment with a satisfactory efficacy, while the specific mechanisms remain unclear and require further investigation. Methods. Overlapped genes of ATAGJ and CIBP obtained from SwissTargetPrediction website and GeneCards database were presented as a Venn diagram. A network diagram of drug-component-target was further established using the Cytoscape 3.6.0 software. The effect of fisetin on Walker 256 cell proliferation was observed by clone formation assay and EDU assay, and the interaction between fisetin and AKT was revealed using the immunoprecipitation assay. Effects of fisetin on AKT/HIF-1α signaling pathway in Walker 256 cells were ultimately detected using Western blot and qPCR assays. Results. The key component fisetin and core target gene AKT were sorted out using the drug-component-target network with a binding energy between fisetin and AKT less than −5 kcal/mol. Clone formation assay and EDU assay showed that fisetin substantially suppressed the proliferation of Walker 256 cells. Immunoprecipitation assay results revealed that the combination of fisetin and AKT decreased the level of AKT/HIF-1α signaling pathway of Walker 256 cells. Conclusions. The fisetin of ATAGJ can markedly suppress Walker 256 cells, and the mechanisms may be intimately associated with the combination of fisetin and AKT. Furthermore, fisetin decreased the level of p-AKT and inhibited the expression of the AKT/HIF-1α signaling pathway.
Network Fault Diagnosis of Embedded System Based on Topology Constraint and Data Mining
Authors: Zhang Tao
Published: February 2022

Maintaining the safe and efficient operation of network technology is an important development task of the computer industry. Topology constraint can optimize and combine the tracking results and select the target objects with better tracking performance to obtain the final tracking results and determine the target scale changes. Data mining technology can reduce the number of combinations to be detected, reduce the workload, and improve the timeliness and accuracy of the process of mining alarm association rules. Therefore, based on the summary and analysis of previous research results, this paper studied the network fault diagnosis of the embedded system method based on topology constraint and data mining. Firstly, a fault diagnosis topology model was established by constructing a topology search algorithm, which eliminated the filtering of association rules without topology relationship; the association rule-based data mining model was analyzed through the collection of network alarm data; the model algorithm was applied to the simulation experiment of network fault diagnosis of the embedded system and achieved good results. The results show that correcting rage of retrieval varies from 0.65 to 090 under different window sizes; the running time of the proposed method drops from 310 s to 35 s during 1–8 step/s of the sliding step, while the node degree ranges from 8 to 14 and diagnostic accuracy ranges from 0.97 to 0.94; the remaining alarm number increases from 0.5 to 3.5 threshold value, while the regular association number distributed in an interval of 40 to 140. The algorithm in this paper provides a reference for further research on network fault diagnosis of the embedded system.
Pharmacological Properties to Pharmacological Insight of Sesamin in Breast Cancer Treatment: A Literature-Based Review Study
Authors: Sohel Md , Islam Md. Nurul , Hossain Md. Arju , Sultana Tayeba , Dutta Amit , Rahman Md. Sohanur , Aktar Suraiya , Islam Khairul , Al Mamun Abdullah
Published: February 2022

The use of dietary phytochemical rather than conventional therapies to treat numerous cancers is now a well-known approach in medical science. Easily available and less toxic dietary phytochemicals present in plants should be introduced in the list of phytochemical-based treatment areas. Sesamin, a natural phytochemical, may be a promising chemopreventive agent aiming to manage breast cancer. In this study, we discussed the pharmacological properties of sesamin that determine its therapeutics opportunity to be used in breast cancer treatment and other diseases. Sesamin is available in medicinal plants, especially in Sesamum indicum, and is easily metabolized by the liver. To better understand the antibreast cancer consequence of sesamin, we postulate some putative pathways related to the antibreast cancer mechanism: (1) regulation of estrogen receptor (ER-α and ER-β) activities, (2) suppressing programmed death-ligand 1 (PD-L1) overexpression, (3) growth factor receptor inhibition, and (4) some tyrosine kinase pathways. Targeting these pathways, sesamin can modulate cell proliferation, cell cycle arrest, cell growth and viability, metastasis, angiogenesis, apoptosis, and oncogene inactivation in various in vitro and animal models. Although the actual tumor intrinsic signaling mechanism targeted by sesamin in cancer treatment is still unknown, this review summarized that this phytoestrogen suppressed NF-κB, STAT, MAPK, and PIK/AKT signaling pathways and activated some tumor suppressor protein in numerous breast cancer models. Cotreatment with γ-tocotrienol, conventional drugs, and several drug carriers systems increased the anticancer potentiality of sesamin. Furthermore, sesamin exhibited promising pharmacokinetics properties with less toxicity in the bodies. Overall, the shreds of evidence highlight that sesamin can be a potent candidate to design drugs against breast cancer. So, like other phytochemicals, sesamin can be consumed for better therapeutic advantages due to having the ability to target a plethora of molecular pathways until clinically trialed standard drugs are not available in pharma markets.
The Effect of Enhanced Multislice Spiral Computed Tomography Scan in Nursing
Authors: Wang Yan , Qian Binyan , Peng Jidong
Published: February 2022

Purpose. Side effects such as local pain and tissue swelling will affect the effect of enhanced multislice spiral computed tomography (CT) scan. The aim of this study was to explore the effect of imaging nursing in enhanced CT scan for heart patients. Method. We selected 86 heart patients to receive enhanced multislice spiral CT scan as the research objects and randomly divided them into the test group and the control group. Imaging nursing and traditional nursing intervention was taken to compare the nursing effects of the two groups. Results. The incidence of unpleasant mood in the test group was 9.3%, which was significantly lower than that in the control group. The nursing satisfaction of the test group was 97.7%, which was much higher than the 79.1% of the control group. At the same time, the visual analogue scale (VAS) score of the test group and the incidence of contrast agent extravasation were significantly lower than those of the control group. Conclusion. The use of imaging nursing for heart patients with enhanced multislice spiral CT scan can reduce the patient’s unhealthy mood and improve nursing satisfaction, and the nursing effect is ideal.
Research on Innovative Design of Product Packaging Based on Big Data Technology
Authors: Gan Fang , Romainoor Nurul Hanim , Guo ZhiMin
Published: February 2022

Traditional product packaging design mainly relies on the designer's personal experience and intuition, but there are problems such as uncontrollable content and lack of knowledge and guidance in the field of product design. With the development of big data technology, product packaging design in the era of big data is carried out under the support of a large amount of real data, which has high predictability, success rate, and short development cycle. Compared with structured data, unstructured data such as text, images, and audio has a higher value. Among them, text big data and image big data have good application prospects in the field of product packaging design due to their easy data acquisition, mature processing technology, and simple operation. This paper proposes a combination of big data technology and neural style transfer model and proposes an innovative design method for product packaging that can generate high-quality images and controllable content. First, the perceptual engineering theory is used to obtain user needs, to build a mapping model between product modeling elements and product semantics, and to guide the selection of product semantics and style maps; second, use neural style transfer models to reconstruct and combine the color features of style maps. After the integration, it migrated to product packaging design, based on big data product packaging innovation design methods, and developed a product innovation design auxiliary prototype system based on actual needs to improve the company’s R&D and innovation capabilities, shorten product development cycles, and reduce R&D costs. Improve product success rate and user satisfaction.
Energy Evolution Law and Fractal Characteristics of Different Rock Specimen Sizes on Dynamic Compression
Authors: Zhou Jun , Xu Wensong , Zhao Guangming , Meng Xiangrui , Li Yingming , Wu Xukun , Li Yuguang , Cheng Xiang
Published: February 2022

To explore the broken energy change and the specimen fragment influence of granite where the length-to-diameter ratio is 0.5–2, the SHPB device was used to perform dynamic loading on the granite specimens. The rock energy evolution law was analyzed by the energy time history curve, and according to rock fragment characteristics, the rock fractal dimension was calculated. The experimental results show that the rock energy-time history curve can be divided into four stages. The incident energy is independent of the length-to-diameter ratio of the rock specimens. When the length-to-diameter ratio of the rock specimens is 0.5–0.9, the difference of incident energy, transmitted energy, and reflection energy of rock specimens is small. With the length-to-diameter ratio increasing, the rock fragment size became larger. These rock fragments have good self-similarity. The rock specimen fractal dimension is at least 1.94, and the maximum D is 2.536. And with the length-to-diameter ratios increasing, the fractal dimension of rock specimens decreases. With the specimen fractal dimension increasing, the energy dissipation density of rock specimens also increases. The higher the energy dissipation density of a rock specimen, the more uniform rock fragments are.
Metformin Alleviates Autistic-Like Behaviors Elicited by High-Fat Diet Consumption and Modulates the Crosstalk Between Serotonin and Gut Microbiota in Mice
Authors: Deng Wenlin , Ke Haoran , Wang Siqi , Li Zitong , Li Sitao , Lv Pinjing , Li Fang , Chen Ye
Published: February 2022

The biological mechanisms linking diet-related obesity and autistic behaviors remain unclear. Metformin has proven to be beneficial in the treatment of many syndromes, including autism spectrum disorder. Therefore, the aim of this study was to assess whether metformin treatment could ameliorate metabolic and behavioral alterations in C57BL/6 mice kept on a high-fat diet (HFD), and whether these changes were related to modifications in the gut microbiota and 5-HT levels. As expected, ten weeks of HFD ingestion increased body weight, adiposity, and glucose levels. HFD-fed mice showed a marked aggravation of repetitive behaviors (marble burying and self-grooming), and this was prevented by metformin administration. In addition, HFD-fed mice increased the total distance travelled in the open field test. This hyperactivity was counteracted by metformin cotreatment. In the elevated plus maze test, HFD-fed mice showed a reduced number of entries into the open arms. Interestingly, both HFD and metformin cotreatment increased social interactions in the three-chamber test. HFD increased the levels of intestinal tryptophan and 5-hydroxyindoleacetic acid. Metformin stimulated gut tryptophan and promoted the synthesis of 5-HT in the HFD group. Lactococcus, Trichococcus, Romboutsia, and Faecalibaculum were enriched in HFD-fed mice, whereas the HFD group cotreated with metformin was enriched in Intestinimonas and L. reuteri. Faecalibacterium was positively correlated with sociability and 5-HT pathway components in mice that received metformin. In summary, HFD consumption elicited a complex phenotype comprising higher levels of anxiety-like and repetitive behaviors but also increased sociability. Metformin could potentially improve HFD-induced disorders in the autistic spectrum through a mechanism involving positive modulation of 5-HT levels in the gut and its microbiota composition.
Systematic Literature Review and Meta-analysis: Real-World Mucosal Healing in Vedolizumab-Treated Patients with Crohn’s Disease
Authors: Danese Silvio , Kamble Pravin , Yang Jin , Le Moine Jean-Gabriel , Khan Shahnaz , Hawe Emma , Agboton Christian , Wang Song , Irving Peter M.
Published: February 2022

Background. Vedolizumab is a gut-selective monoclonal anti-α4β7-integrin antibody approved for the treatment of adults with moderately to severely active Crohn’s disease (CD). Aim. To conduct a systematic literature review and meta-analysis of published real-world studies examining mucosal healing (MH) rates in patients with CD treated with vedolizumab in routine clinical practice. Methods. MEDLINE-, Cochrane-, and EMBASE-indexed publications from January 2014 to January 2020 and 2018-2019 conference abstracts were searched for real-world studies reporting MH-related outcomes in vedolizumab-treated adults with CD. A meta-analysis was conducted in R to generate pooled estimates of MH. The primary analysis included studies reporting point estimates of MH/endoscopic remission as absence of ulcers/erosions and/or Simple Endoscopic Score for CD (SES-CD)

cut
−
points
<
4

, at 6 and 12 months. Results. The systematic literature review included 36 studies, predominantly of antitumour necrosis factor-experienced patients. MH and endoscopic remission were the most frequently reported endpoints. MH rates were 10.1%-46.0% at 6 months (ten studies) and 21.2%-62.5% at 12 months (eight studies). Fifteen studies defining MH as absence of ulcers/erosions and/or SES-CD

cut
−
points
<
4

were included for meta-analysis. Pooled MH rates for the primary analysis were 31.8% at 6 months (95% confidence interval (CI): 25.6-38.3; five studies,

N
=
223

) and 33.4% at 12 months (95% CI: 25.9-41.4; three studies,

N
=
151

). Conclusion. Approximately one-third of vedolizumab-treated patients with CD achieved MH at both 6 and 12 months in real-world clinical settings, despite utilisation in largely biologic-refractory patients. These findings confirm the effectiveness of vedolizumab for achieving MH in patients with CD.
Risk Factors and Nursing Countermeasures of Ventilator-Associated Pneumonia in Children in the Intensive Care Unit
Authors: Chen Rong , Liu Yu , Zhang Xiaohong , Yang Qin , Wang Xiao
Published: February 2022

Objective. This study discussed and analyzed the risk factors and nursing countermeasures of ventilator-associated pneumonia (VAP) in the children intensive care unit (ICU). Methods. In this study, 155 children with mechanical ventilation in the pediatric intensive care unit from Oct. 2018 to Oct. 2020 were chosen as research objects. We retrospectively analyzed the clinical data of children and divided them into VAP groups and non-VAP groups according to the occurrence of VAP. Subsequently, we adopted a univariate and multivariate logistic regression model to analyze and clarify the risk factors of VAP and formulated the corresponding nursing countermeasures. Results. 49 cases of total research objects had occurred VAP, with an infection rate of 31.62%. The primary pathogenic bacteria were Gram-negative bacteria (43/70, 61.43%). According to multivariate logistic regression analysis, the duration of mechanical ventilation, invasive procedures, and application of hormones and antacids are all independent risk factors for VAP in pediatric ICU. The VPA group had longer hospital stay than the non-VAP group, and the difference was statistically significant ((20.92 ± 4.16)d, (15.24 ± 3.77)d, t = 8.4383,

P

 ≤ 0.001). The hospitalization cost of the VPA group was substantially higher than that of the non-VAP Group ((45.8 ± 10.4) thousand Yuan, (33.2 ± 4.3) thousand Yuan, t = 10.6822,

P

 ≤ 0.001). Conclusion. Children admitted to the pediatric ICU have a high VAP incidence. The primary pathogenic bacteria are Gram-negative bacteria. As the occurrence of VAP is closely related to a variety of factors, we should take targeted nursing countermeasures to reduce the duration of mechanical ventilation and the frequency of invasive operations and use the hormone and antacids rationally to reduce the risk of VAP and improve the prognosis.
Path Design and Planning and Investment and Construction Mode of Multimodal Transport Network Based on Big Data Analysis
Authors: Wang Shuai , Fu Shaochuan
Published: February 2022

Currently, long‐distance freight transport is shifting towards multimodal transport, the combination of multiple freight transport modes. Multimodal transport enables enterprises with the same logistics function to operate on the same level of the supply chain. Through horizontal cooperation, these enterprises can give play to their advantages, make up their deficiencies, improve service levels, reduce cost input, and thereby enhance market status. Therefore, multimodal transport is an intensive development model that promotes the alliance between giants. The reasonable path design and planning (PDP) and investment and construction mode (ICM) of the multimodal transport network help freight demanders, as well as multimodal freight transport platforms, obtain the maximum profit. Therefore, this paper explores the PDP and ICM of the multimodal transport network based on big data analysis. Firstly, the influencing factors and behavioral features of multimodal transport were deeply examined, drawing on the logit model and the big data on multiple freight services, namely, railway transport, highway transport, waterway transport, and airway transport. After classifying the freights, the authors analyzed the modeling and decision‐making of path design and optimization (PDO) for multimodal transport network. The proposed model was proved effective through experiments. This paper theoretically explores the goals, principles, and needs of path selection in the modern transportation industry. In a realistic sense, the research findings help decision‐makers optimize their decisions on the multimodal transport network and operate the network at the minimum transport cost.
Dietary Inflammatory Index in relation to Type 2 Diabetes: A Meta-Analysis
Authors: Motamedi Amir , Askari Mohammadreza , Mozaffari Hadis , Homayounfrar Reza , Nikparast Ali , Ghazi Maryam Lafzi , Nejad Maryam Mofidi , Alizadeh Shahab
Published: February 2022

Background and Aims. Epidemiologic studies show a strong association between chronic inflammation and type 2 diabetes (T2D). Diet may also affect the risk of T2D by modulating inflammation. This meta-analysis aimed to assess the relation of dietary inflammatory index (DII) and risk of T2D. Methods. PubMed and Scopus were systematically searched from their inception to September 2020 to identify relevant studies. Relative risks, hazard ratios, or odds ratios (OR), with their corresponding 95% confidence intervals (95% CI), were calculated and pooled using a random-effects model. Results. A total of 48 different studies, with a total sample size of 1,687,424 participants, were eligible to be included in this meta-analysis. In the overall analysis, no significant association was observed between DII and risk of T2D (OR = 1.03, 95% CI: 0.91 to 1.15), with significant evidence for heterogeneity (I2 = 96.5%,

P

 < 0.001); however, higher DII was identified as being significantly related to increased risk of T2D in high quality studies (OR = 1.58, 95% CI: 1.15 to 2.17). In the stratified analysis by the dietary assessment tool, background disease, and sex of participants, DII showed no significant association with T2D. Conclusions. Higher DII might be associated with an increased risk of T2D. Additional well-designed studies are required to confirm this finding.
The Association of Weight Loss, Weight Status, and Abdominal Obesity with All-Cause Mortality in Older Adults
Authors: Alharbi Tagrid Abdullah , Ryan Joanne , Freak-Poli Rosanne , Gasevic Danijela , Scali Jacqueline , Ritchie Karen , Ancelin Marie-Laure , Owen Alice J.
Published: February 2022

Objectives: The objectives of this study were to examine whether weight loss, weight status (based on body mass index [BMI] categories), and abdominal obesity (based on waist circumference [WC]) were associated with a 17-year mortality risk in community-dwelling older adults. Methods: Participants were 2,017 community-dwelling adults aged 65 years or above in the longitudinal Enquête de Santé Psychologique-Risques, Incidence et Traitement study. Self-reported weight loss was collected at baseline during face-to-face interviews. Bodyweight (kg), height (m), and WC (cm) were independently measured at the baseline. BMI was categorized as follows: underweight (BMI <18.5 kg/m2), normal weight (18.5–24.9 kg/m2), overweight (25–29.9 kg/m2), and obese (≥30 kg/m2). Abdominal obesity was defined by a WC of ≥102 cm in men and ≥88 cm in women. Adjusted Cox proportional hazards models were used to examine associations of weight loss, weight status, and abdominal obesity with all-cause mortality. Results: Over 17 years of follow-up (median 15.5 years), 812 participants died. Abdominal obesity compared to nonabdominal obesity was associated with a 49% increased mortality risk (95% confidence interval (CI): 1.22–1.83). However, being overweight (but not obese) was associated with a 20% decreased risk (95% CI: 0.66–0.97) compared to a normal BMI. Gender did not affect these associations. In the whole cohort, self-reported weight loss at baseline was not associated with an increased mortality risk after adjusting for health and lifestyle factors. However, in men, a baseline self-reported recent weight loss of >3 kg was associated with a 52% increase in mortality risk (95% CI: 1.05–2.18) in a fully adjusted model. Conclusion: In community-dwelling adults aged ≥65 years, abdominal obesity was strongly associated with increased mortality risk. Being overweight appeared, however, to be protective against mortality. Modest self-reported weight loss was not associated with all-cause mortality in community-dwelling older adults after adjusting for health and lifestyle factors. However, men reporting recent weight loss of more than 3 kg may be at increased risk. The findings of this study support the use of WC, rather than BMI, as a predictor of mortality risk in older adults.
O Amante da China do Norte de Marguerite Duras: a música e sua significância
Authors: Kuntz Maria Cristina
Published: February 2022

Marguerite Duras (1914-1996) é considerada, hoje, uma das mais importantes escritoras francesas da segunda metade do século XX. Descontente com a filmagem de O Amante por Jean-Jacques Annaud (1990), Duras retoma a história de sua adolescência e escreve O Amante da China do Norte (1991). Trata-se de um texto singular que pretende ser um roteiro de filmagem, mas definido pela própria autora como “romance”. Barthes (1982) reflete sobre a “escuta”, que define como algo que pode determinar, despertar no homem sentimentos prazerosos ou ameaçadores. Sabe-se que a música é sobretudo ambivalente e se assemelha a uma linguagem, podendo transmitir uma intenção (ADORNO). Considerando com Kristeva (1969) que a palavra literária é resultado de um “croisement de surfaces textuelles”, no presente trabalho será examinado o cruzamento entre a “escuta” das músicas mencionadas na obra por parte das personagens e do narrador e a palavra escrita, bem como seu significado, não só como pano de fundo do texto, mas como sua parte integrante e até como fio condutor da intriga do “texto-filme”.
Una mirada desde la alcantarilla: uma versão vocal do poema homônimo de Alejandra Pizarnik
Authors: Brandes Inés Terra
Published: February 2022

Este artigo discorre sobre a peça Una mirada desde la alcantarilla, uma peça vocal criada a partir da leitura do poema homônimo da escritora argentina Alejandra Pizarnik (1936-1972) e apresentada como parte do terceiro capítulo “A voz como prática” na minha dissertação de mestrado. Este trabalho dá ênfase ao conhecimento da voz como um processo expandido de criação e aborda a leitura e a pesquisa vocal pela ótica da performance e da performatividade, valorizando a poesia como ponto de partida para a composição musical e realizando paralelos entre a noção de duplo como estratégia literária e o duplo como desdobramento do eu durante a exploração vocal. A escrita nômade de Pizarnik e a sua visão do corpo como um umbral (entre tipos de corporalidades diferentes) direcionam a pesquisa de sonoridades para a alternância de tipos de emissão vocal e ao mesmo tempo para a valorização de transições sutis entre vocalidades.
Subindo o Morro Velho: notas para preparação de uma performance
Authors: Teixeira William , Gomes Juliana Araújo , Silva Lucas Mateus , Bulhões Ricardo Magalhães
Published: February 2022

O artigo apresenta o relato da preparação de uma performance, pelos autores, da canção Morro Velho, composta por Milton Nascimento, mas aqui considerada em sua versão realizada por Elis Regina. Através de uma pesquisa artística de caráter experimental, o objetivo final da pesquisa em criar uma nova interpretação para a canção tem sua etapas de desenvolvimento aqui descritas. Além dos estágios de formulação da interpretação, apresentam-se as reflexões suscitadas e o diálogo com a literatura disponível para resolução de problemas, sobretudo as noções de análise imanente (Nattiez, 1990 e Ferraz, 2011), discurso lítero-musical (Costa, 2001) e a análise semiótica da gestualidade oral (Tatit, 2002). Por fim, demonstra-se a importância de se considerar a performance tanto enquanto dado analítico, quanto como prática cuja realização é produtora de questões de pesquisa e de novas soluções para a significação.
Gal, a fatal: o tropicalismo musical e o gesto interpretativo de Gal Costa
Authors: Cordeiro Taissa Maia Amorim
Published: February 2022

Este artigo apresenta um novo recorte dos fatos relacionados ao movimento tropicalista, a fim de refletir sobre o papel de Gal Costa na história do tema e sobre os sentidos de seu canto para a crítica musical brasileira. Faz-se isso por meio de uma pesquisa que foi empreendida em entrevistas dessa artista em jornais de grande circulação, além de documentários e programas de televisão. Ao longo do artigo, a história oficial desse movimento de vanguarda e a tradição crítica que pensou o tema foram indagadas, com o objetivo de melhor compreender o lugar ocupado por Gal nos debates que envolvem o tropicalismo musical. Não só isso, reflete-se sobre conceitos como autoralidade, composição, a corporalidade empregada como discurso cênico, entre outros tópicos que residem nas interseções entre música e literatura.
Cardiovascular Disease Screening in Women: Leveraging Artificial Intelligence and Digital Tools
Authors: Adedinsewo Demilade A. , Pollak Amy W. , Phillips Sabrina D. , Smith Taryn L. , Svatikova Anna , Hayes Sharonne N. , Mulvagh Sharon L. , Norris Colleen , Roger Veronique L. , Noseworthy Peter A. , Yao Xiaoxi , Carter Rickey E.
Published: February 2022

Cardiovascular disease remains the leading cause of death in women. Given accumulating evidence on sex- and gender-based differences in cardiovascular disease development and outcomes, the need for more effective approaches to screening for risk factors and phenotypes in women is ever urgent. Public health surveillance and health care delivery systems now continuously generate massive amounts of data that could be leveraged to enable both screening of cardiovascular risk and implementation of tailored preventive interventions across a woman’s life span. However, health care providers, clinical guidelines committees, and health policy experts are not yet sufficiently equipped to optimize the collection of data on women, use or interpret these data, or develop approaches to targeting interventions. Therefore, we provide a broad overview of the key opportunities for cardiovascular screening in women while highlighting the potential applications of artificial intelligence along with digital technologies and tools.
Heart Failure Subtypes and Cardiomyopathies in Women
Authors: DeFilippis Ersilia M. , Beale Anna , Martyn Trejeeve , Agarwal Anubha , Elkayam Uri , Lam Carolyn S.P. , Hsich Eileen
Published: February 2022

Heart failure affects over 2.6 million women and 3.4 million men in the United States with known sex differences in epidemiology, management, response to treatment, and outcomes across a wide spectrum of cardiomyopathies that include peripartum cardiomyopathy, hypertrophic cardiomyopathy, stress cardiomyopathy, cardiac amyloidosis, and sarcoidosis. Some of these sex-specific considerations are driven by the cellular effects of sex hormones on the renin-angiotensin-aldosterone system, endothelial response to injury, vascular aging, and left ventricular remodeling. Other sex differences are perpetuated by implicit bias leading to undertreatment and underrepresentation in clinical trials. The goal of this narrative review is to comprehensively examine the existing literature over the last decade regarding sex differences in various heart failure syndromes from pathophysiological insights to clinical practice.
Art and Class Struggle
Authors: Lezra Jacques , Durán José María , Baumbach Nico , Marsh Steven , Toscano Alberto , Vishmidt Marina , Yue Genevieve
Published: February 2022

What do we need to know about “art” or “class struggle” before considering their relation to one another? Could you describe a specific work or text that might serve as an illustration of class struggle or as an exploration of the problem of representing it? Let us say that visual art, broadly speaking, does express the worldview of the dominant class. What kind of art then expresses the worldview of, say, hedge fund managers? Does the dialectic of the visible and invisible still hold for conceptual and post-conceptual art? What alternative critical apparatus would you propose, since neither Lenin nor John William Cooke seemed to care much for art. Why should we?
Art under Neoliberalism
Authors: Appadurai Arjun , Bockman Johanna , Heinich Nathalie , Konings Martijn , La Berge Leigh Claire , Lovink Geert , Prado Ignacio M. Sánchez , Thayer Willy
Published: February 2022

Apart from the longstanding and much-debated problem of art's commodification, how does neoliberalism transform and determine the conditions of artistic practice? Further, if neoliberalism is a substantially distinct stage in the history of capitalism, and not merely its intensification, what are the implications of this new condition for the practice and criticism of contemporary art? What does it mean to practice and theorize art, to be an artist or critic, under neoliberalism? Drawing on the central topic of this issue, is aesthetic, artistic, or political radicality in art still possible under the neoliberal condition? Can, or should, artistic practice constitute a significant site of resistance? Conversely, is the contemporary art world a paradigmatic case of, and even a model for, neoliberal capitalism?
Contextualization and the ‘Death and Resurrection’ Pattern
Authors: Kramer E.J. David
Published: February 2022

Grasping contextualization through the New Testament pattern of ‘death and resurrection’, invigorates the conversation between missiology and systematic theology and affords numerous conceptual benefits. By employing N.T. Wright’s rendition of the Apostle Paul’s life-transformation as ‘dying and rising with Christ’, a pattern suggests itself that accounts for both continuity and discontinuity between Paul’s former life and his life ‘in Christ’. When this pattern informs theological reflection on contextualization, its shape and significance can be better appreciated and named. This is demonstrated with reference to three systematic loci. First, Christology: the widespread incarnational model for understanding contextualization is expanded to include Christ’s death and resurrection. Second, soteriology: the death and resurrection pattern llumines conversion as both a point and a process. Third, eschatology: this same pattern sheds light on contextualization’s final significance for humanity’s life in the new creation.
Constitutional Courts in the Arab World and Freedom of Expression: A Defender or Suppressor
Authors: AlZumai Fahad
Published: February 2022

This paper examines the role of constitutional courts in the Arab world in relation to freedom of expression. The role of constitutional courts as gatekeepers of constitutional rights in the Arab world has neither been fully assessed nor analyzed. This paper will analyze and review the decisions issued by constitutional courts in the Arab world with an emphasis on constitutional courts in Egypt, Kuwait, Tunisia, and Morocco. Some of these courts have been active in their roles as gatekeepers and have issued relatively progressive decisions in the area of freedom of expression. However, these successes in protecting this constitutional right have been the exception rather than the rule, and hence, this paper will try to examine the reasons behind the failure of these courts in safeguarding this right. The paper will also explore the jurisprudence as to the understanding of the legal boundaries of freedom of expression, as all of the countries in the Arab world follow civil legal systems, and hence, jurisprudence plays a major role in how the courts interpret these rights.
A Collection of Jibbali/Śḥərɛ̄́t Proverbs from Ali al-Shahri’s Publication The Language of Aad/لغة عاد
Authors: Castagna Giuliano
Published: February 2022

Jibbali/Śḥərɛ̄́t is a language belonging to the Modern South Arabian (msa) branch of Semitic. It is currently endangered and spoken by an estimate of 50,000 ~ 70,000 people living in the Omani governorate of Dhofar. Similarly to the other msa languages, it is unwritten, and the survival of its speakers’ traditional knowledge rests on their ability to memorise and retain a large amount of information in the form of poetry, songs, folk-tales and proverbs.

In 2000, ʕAli al-Shahri, a Dhofari historian and native speaker of Jibbali/Shahret, published a bilingual English/Arabic monograph named The Language of Aad/لغة عاد which is intended as an introduction to a wide array of aspects of the local culture, ranging from the toponymy of Dhofar, its traditional dances, songs, poetry and proverbs, to more unusual topics such as star-names, children games, traditional land allotment and more. This paper focuses on one of the most prominent topics of the monograph in question, namely a collection of 210 proverbs. Each proverb in this collection is provided with a translation in English and Arabic, and is presented in al-Shahri’s work by means of an idiosyncratic transcription system based on the Arabic script, in which linguistic sounds specific to msa are represented by coloured Arabic characters, to the detriment of comprehension.

This paper aims at providing a linguistically viable description of these proverbs, by presenting them in a standard Semitic transcription. The transcription presented proceeds from the analysis of al-Shahri’s original recording (which features al-Shahri himself uttering these 210 proverbs one by one) stored at the Semitische Tonarchiv (SemArch) at the University of Heidelberg. Additionally, the original English and Arabic translations provided by al-Shahri are reported. These are followed by a brief commentary containing a description of each relevant term, as well as a general account of the meaning of each proverb.

The conclusions pinpoint some phonetic, phonological, morphological, syntactic and lexical characteristics of the material examined, and identify a number of divergences and commonalities with other present-day and ancient Semitic subgroups which bear witness to the long and unwritten history of the Jibbali/Śḥərɛ̄́t language.
The Californian clade of Cybaeus (Araneae: Cybaeidae) in the Nearctic: the septatus species group and three unplaced species
Authors: BENNETT ROBB , COPLEY CLAUDIA , COPLEY DARREN
Published: February 2022

North American species of the genus Cybaeus L. Koch (Araneae: RTA clade: Cybaeidae) are woodland spiders classified in Holarctic and Californian clades. Here, in the fifth and final paper in a series reviewing the six Californian clade species groups, we present eight species. Five species comprise the septatus group: Cybaeus chauliodous Bennett, C. lockeae Bennett spec. nov., C. septatus Chamberlin & Ivie, C. somesbar Bennett, and C. viator Bennett spec. nov. The male of C. lockeae spec. nov. is unknown; the male of C. somesbar is newly described. As well, we recognize and review three Californian clade species (C. cribelloides Chamberlin & Ivie, C. gidneyi Bennett, and C. irreverens Bennett spec. nov.) that we have been unable to place confidently in any of the six species groups. Descriptions, illustrations, distribution maps, and (for the members of the septatus group) an identification key are provided. Finally, we summarize the taxonomic status of all described North American species of Cybaeus and highlight some conservation concerns.
The influence of PM2.5 exposure on kidney diseases
Authors: Xu Wenqi , Wang Shaopeng , Jiang Liping , Sun Xiance , Wang Ningning , Liu Xiaofang , Yao Xiaofeng , Qiu Tianming , Zhang Cong , Li Jing , Deng Haoyuan , Yang Guang
Published: February 2022

The harm of air pollution to public health has become a research hotspot, especially atmospheric fine-particulate matter (PM2.5). In recent years, epidemiological investigations have confirmed that PM2.5 is closely related to chronic kidney disease and membranous nephropathy Basic research has demonstrated that PM2.5 has an impact on the normal function of the kidneys through accumulation in the kidney, endothelial dysfunction, abnormal renin-angiotensin system, and immune complex deposition. Moreover, the mechanism of PM2.5 damage to the kidney involves inflammation, oxidative stress, apoptosis, DNA damage, and autophagy. In this review, we summarized the latest developments in the effects of PM2.5 on kidney disease in human and animal studies, so as to provide new ideas for the prevention and treatment of kidney disease.
Returning to basic principles to develop more effective treatments for central nervous system disorders
Authors: Wexler Bruce E
Published: February 2022

Development of new treatments for diseases of the central nervous system (CNS) is stalled. Of candidate drugs developed through costly preclinical research, 93% fail clinical trials. Hoped-for improvements in diagnosis or treatment from decades of positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) imaging have yet to materialize. To understand what we are doing wrong, I begin with recognition that all aspects of life, including the brain and mind, are physical phenomena consistent with processes described by physicists. Two processes, emergence and entropy, are of particular relevance in complex arrangements of matter that constitute life in general and the brain in particular. The human brain functions through dynamically reconfiguring and hierarchically organized neural functional systems with emergent properties of cognition, emotion, and conscious experience. These systems are shaped and maintained by negentropic environmental input transformed by sensory receptors into neural signals that trigger epigenetic neuroplastic processes. CNS diseases produce clinical disorders by disrupting these systems. As researchers seek appropriate levels of system organization at which to characterize and treat illness, focus has been on medications that impact processes at lower levels or transcranial electric or magnetic stimulation that impact broad contiguous swaths of tissue. Neither align with the brain’s neurosystem organization and therefore lack specificity necessary to be effective and to limit side effects. Digital neurotherapies (DNTs), in contrast, align with neurosystem organization and achieve the needed specificity using the same input pathways and neuroplastic processes that created the neural systems organization to repair it. The omission of DNTs from major systems-based initiatives represents powerful residua of dualist thinking. Interventions based on perceptual and cognitive processes are not thought of as being as physical as drugs or electric or magnetic stimulation through the skull. In fact, they are examples of the most basic processes that create and support life itself.
Svetlanaite, SnSe, a new mineral from the Ozernovskoe deposit, Kamchatka peninsula, Russia
Authors: Okrugin Victor M. , Vymazalová Anna , Kozlov Vladimir V. , Laufek František , Stanley Chris J. , Shkilev Ilya A.
Published: February 2022

Svetlanaite, SnSe is a new mineral discovered from the high-sulfidation epithermal Au-deposit Ozernovskoe, Kamchatka peninsula, Russia. It forms tiny euhedral spindles (0.5–2 μm × 10–15 μm) in quartz, in close association with cassiterite, rutile, mohite, mawsonite, kiddcreekite, hemusite, tellurium, kostovite and Se-bearing ‘fahlores’ (Se-goldfieldite–Se(Bi)-tetrahedrite–Se-tennantite). In plane-polarised light, svetlanaite is light-grey, pleochroic from white to cream and strongly anisotropic in shades of light blue, dark blue, khaki and orange–brown; it exhibits no internal reflections. Reflectance values of synthetic analogue of svetlanaite in air (R1,R2 in %) are: 50.9, 56.5 at 470 nm, 50.2, 56.7 at 546 nm, 49.5, 55.3 at 589 nm and 48.7, 53.4 at 650 nm. Twelve electron-microprobe analyses of svetlanaite give an average composition: Sn 61.30, Se 37.22 and S 1.25 total 99.79 wt.%, corresponding to the empirical formula Sn1.01(Se0.92S0.07)Σ0.99 based on 2 atoms; the average of seven analyses on its synthetic analogue is: Sn 59.98 and Se 39.71, total 99.59 wt.%, corresponding to Sn1.00Se1.00. The density, calculated on the basis of the empirical formula, is 6.08 g/cm3. The mineral is orthorhombic, space group Pnma, with a = 11.500(2), b = 4.154(2), c = 4.445(2) Å, V = 212.34(14) Å3 and Z = 4. The crystal structure was solved and refined from the powder X-ray-diffraction data of synthetic SnSe. It crystallises in the GeS-structure type. It is isostructural with the mineral herzenbergite (SnS). The mineral name is in honour of Svetlana K. Smirnova, a Russian mineralogist, for her contributions to geology in the epithermal Au–Ag deposits of the Tien–Shan region.
Clinical Activity of Single Dose Systemic Oncolytic VSV Virotherapy in Patients with Relapsed Refractory T-Cell Lymphoma
Authors: Cook Joselle , Peng Kah Whye Whye , Witzig Thomas E. , Broski Stephen M , Villasboas Jose Caetano , Paludo Jonas , Patnaik Mrinal M , rajkumar vincent Vincent , Dispenzieri Angela , Leung Nelson , Buadi Francis , Bennani Nora Nora , Ansell Stephen M. , Zhang Lianwen , Packiriswamy Nandakumar , Balakrishnan Baskar , Brunton Bethany , Giers Marissa , Ginos Brenda , Dueck Amylou C. , Geyer Susan , Gertz Morie A , Warsame Rahma , Go Ronald S. , Hayman Suzanne R , Dingli David , Kumar Shaji K , Bergsagel P. Leif , Munoz Javier , Gonsalves Wilson I , Kourelis Taxiarchis V. , Muchtar Eli , Kapoor Prashant , Kyle Robert A , Lin Yi , Siddiqui Mustaqeem , Fonder Amie , Hobbs Miriam , Hwa Yi Lisa , Naik Shruthi , Russell Stephen J , Lacy Martha Q
Published: February 2022

Clinical success with intravenous (IV) oncolytic virotherapy (OV) has to date been anecdotal. Here, we conducted a phase 1 clinical trial of systemic OV therapy and investigated the mechanisms of action in responding T-cell lymphoma (TCL) patients. A single IV dose of VSV-IFNβ-NIS was administered to patients with relapsed refractory hematologic malignancies to determine safety and efficacy across 4 dose levels (DL). Correlative studies were undertaken to evaluate viremia, virus shedding, virus replication and immune responses. Fifteen patients received VSV-IFNβ-NIS (7 multiple myeloma, 7 TCL, 1 acute myeloid leukemia); 3 patients were treated at each DL1 through DL3 (0.05, 0.17, and 0.5 x 1011 TCID50), and 6 at DL4 (1.7 x 1011 TCID50). There were no dose limiting toxicities. 3 of 7 patients with TCL had RECIST responses: a 3-month PR at DL2, a 6-month PR and a durable CR ongoing at 20 months at DL4. Viremia peaked at the end of infusion and no infectious virus shedding was detected. Plasma interferon-β levels, a biomarker of VSV-IFNβ-NIS replication, peaked between 4h and 48h post infusion. The patient with CR had robust viral replication with increased ell free DNA in her plasma, a very high peak IFNβ level of 18,213 pg/ml, a strong anti-VSV neutralizing antibody response, and increased numbers of tumor reactive T-cells. VSV-IFNβ-NIS as a single agent was effective in patients with TCL resulting in durable disease remissions in heavily pretreated patients. Correlative analyses suggest that responses may be due to a combination of direct oncolytic tumor destruction and immune-mediated tumor control. Further clinical testing is warranted. (This trial is registered at www.clinicaltrials.gov as NCT03017820).