bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional results in the treatment of patients with soft tissue injuries to the volar aspect of the wrist
Authors: Maljković Filip , Matić Slađana
Published: January 2024

Introduction: The hand is a very important body part with complex anatomy. Important neurovascular structures are located in the hand. Many superficial injuries of the hand, which may at first glance appear harmless, are often associated with injuries to tendons, nerves, and blood vessels. This paper describes soft tissue injuries, while injuries to the bone have been excluded from the study. Aim: The aim of this study is to present the functional outcome of the treatment of patients with soft tissue wounds to the volar aspect of the wrist. Methods: A retrospective analysis of 20 patients treated at the Microsurgery Department of the Emergency Center in Belgrade was performed. We observed the following: gross grip strength (GGS) of the hand, range of motion, the two-point discrimination test (2PD), while the patients filled out the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire. Results: In our study, the GGS of the injured hand was 80.9% of the strength of the uninjured hand. The mean range of motion of the wrist, as well as of the DIP, PIP, and MCP joints, ranged from 77.45% to 91.6%, as compared to the uninjured hand. An S3+ level of sensory recovery was achieved by 10% of patients. The average DASH score was 19.78. Conclusion: Our study shows that proper and timely treatment is necessary for a good functional result in the treatment of these injuries.
Neuropsychiatric lupus: Two faces of one disease (two case reports)
Authors: Dimitrijević Milan , Stojanović Maja , Mišković Rada , Kusić Nataša , Rašković Sanvila
Published: January 2024

Introduction: Neuropsychiatric lupus (neuropsychiatric systemic lupus erythematosus - NPSLE) is a form of a systemic autoimmune disease - systemic lupus erythematosus (SLE), with dominant central and peripheral nervous system involvement. Nuclear magnetic resonance imaging (NMRI) of the brain is considered the gold standard for diagnosing patients with NPSLE. Treatment of NPSLE includes the following: high doses of corticosteroids, methylprednisolone pulse therapy, intravenous immunoglobulins, plasmapheresis, immunosuppressants (cyclophosphamide, azathioprine, mycophenolate mofetil), and biological therapy - rituximab. Case reports: In this paper, we present two patients diagnosed with neuropsychiatric lupus, with different clinical manifestations of the disease, as well as the diagnostics performed, and the good clinical outcomes of immunosuppressive therapy achieved in both patients. Conclusion: The pathogenesis of NPSLE involves neuroinflammatory (autoimmune) and ischemic mechanisms. Neuroimaging has shown good results in differentiating patients with SLE from controls. The goal of SLE treatment is to achieve remission or low disease activity and to prevent episodes of exacerbation. Treatment with intravenous cyclophosphamide as well as with systemic corticosteroids has shown significantly positive results in patients with NPSLE. There is great need, in the future, for new biomarkers in the serum and cerebrospinal fluid (CSF), as well as for more innovative radiological procedures. Additional clinical trials that would lead to new therapeutic options for the treatment of NPSLE are necessary.
The process model as a basis for designing the organizational structure of the quality system
Authors: Josić Strahinja , Živković Nedeljko
Published: January 2024

Designing appropriate organization that can use all of its potentials is one of main challenges for organization. Also, organizations realized that quality system and its processes has significant role in their business. Therefore, organizing quality system is important factor of successful business. The paper will systematize all areas with associated processes, which are closely related to the quality system (standardization, metrology, environmental protection, etc.). as a theoretical model with possible use in organizing the quality system.
Reduction of dust concentration and emission of pollutants in the air in the textile industry
Authors: Ćirović Nataša , Aksentijević Snežana , Krivokuća Milutin , Alendarević Adela
Published: January 2024

According to research by many authors, the textile industry is one of the major polluters of the environment. In order to sustain itself, it is necessary to find new procedures to reuse materials and thereby eliminate pollution and reduce the damage that has been done so far. The aim of the paper is to describe the existing devices used to reduce the concentration of dust, for example the textile plant Tkačnica and the emission of pollutants into the air in plants where dyeing of textile products is carried out. Also, the paper contains suggestions for an even more effective reduction of the concentration of dust in the air, that is, reducing the emission of polluting gases into the air in textile industry plants.
Mehr Sicherheit für den Sicherheitsapparat
Authors: Jaschinski Jannik , Steinbach Armin
Published: January 2024

Wie Thüringens Polizei und Verfassungsschutz besser vor einer autoritären Regierung geschützt werden könnten
Hehrer Zweck mit hohen Hürden
Authors: Meickmann Till Valentin
Published: January 2024

Landwirtschaftsminister Cem Özdemir fordert eine eigene Abgabe auf tierische Erzeugnisse wie Fleisch, Milch und Eier, um daraus Hilfen für den tierfreundlichen Umbau der Nutztierhaltung zu finanzieren. Mit dieser sogenannten Tierwohlabgabe greift er die Empfehlungen der Borchert-Kommission auf, die bereits seine Vorgängerin Julia Klöckner in einer umfangreichen Machbarkeitsstudie auf ihre Umsetzbarkeit untersuchen ließ. Für die Einführung einer Tierwohlabgabe sind erhebliche verfassungs- und unionsrechtliche Hürden zu überwinden. Während eine Sondergabe kaum mit der diesbezüglichen Rechtsprechung des Bundesverfassungsgerichts zu vereinbaren sein dürfte, setzt das unionsrechtliche Verbot diskriminierender Abgaben einer zweckgebundenen Steuer Grenzen.
The Development of Online and Offline (O2O) to Create a Teaching Model for Football Courses at the University
Authors: Zhao Shaolan , Siriphan Chanchai
Published: January 2024

Background and Aim: With the continuous development of modern science and technology, information teaching has attracted much attention. Using information technology to promote educational innovation is important research in China's educational reform. Online and offline (O2O) teaching is based on traditional teaching based on the Internet-established teaching mode. This student-oriented teaching model realizes the mix of online and offline teaching. This study was to develop online and offline (O2O) to create a teaching model for football courses in course mates.
Methods: 40 teachers and 359 students were selected as samples for this study by a combination of questionnaire survey, expert interview, and special software package, and data were collected. The research process includes a comprehensive survey of the current teaching model. Then, using Delphi consensus to revise the first draft of the O2O football course teaching model. Finally, focus groups and appreciation experts are used to determine the framework k of the O2O football teaching model.
Results: The analysis reveals that universities need a comprehensive football teaching model. The proposed O2O teaching model includes six basic elements: theoretical basis, teaching objectives, teaching content, teaching procedures, teaching evaluation, and teaching facilities, and is further divided into 13 secondary elements and 44 tertiary elements.
Conclusion: The proposed O2O teaching model provides an innovative teaching model for college football teaching. Combine modern information technology with football teaching to promote the innovation of football education. It is consistent with the idea of China's modernization education reform. This teaching mode is expected to change the traditional teaching mode of football and set a benchmark for the teaching reform of other physical education.
NCCN Guidelines® Insights: Merkel Cell Carcinoma, Version 1.2024
Authors: Schmults Chrysalyne D. , Blitzblau Rachel , Aasi Sumaira Z. , Alam Murad , Amini Arya , Bibee Kristin , Bolotin Diana , Bordeaux Jeremy , Chen Pei-Ling , Contreras Carlo M. , DiMaio Dominick , Donigan Jessica M. , Farma Jeffrey M. , Ghosh Karthik , Harms Kelly , Ho Alan L. , Lukens John Nicholas , Manber Susan , Mark Lawrence , Medina Theresa , Nehal Kishwer S. , Nghiem Paul , Olino Kelly , Park Soo , Patel Tejesh , Puzanov Igor , Rich Jason , Sekulic Aleksandar , Shaha Ashok R. , Srivastava Divya , Thomas Valencia , Tomblinson Courtney , Venkat Puja , Xu Yaohui Gloria , Yu Siegrid , Yusuf Mehran , McCullough Beth , Espinosa Sara
Published: January 2024

The NCCN Guidelines for Merkel Cell Carcinoma (MCC) provide recommendations for diagnostic workup, clinical stage, and treatment options for patients. The panel meets annually to discuss updates to the guidelines based on comments from expert review from panel members, institutional review, as well as submissions from within NCCN and external organizations. These NCCN Guidelines Insights focus on the introduction of a new page for locally advanced disease in the setting of clinical node negative status, entitled “Clinical N0 Disease, Locally Advanced MCC.” This new algorithm page addresses locally advanced disease, and the panel clarifies the meaning behind the term “nonsurgical” by further defining locally advanced disease. In addition, the guideline includes the management of in-transit disease and updates to the systemic therapy options.
Machine Learning Operations (MLOps): Challenges and Strategies
Authors: Singla Amandeep
Published: January 2024

Machine Learning Operations (MLOps) is a critical discipline that aims to streamline and enhance the end-to-end machine learning (ML) lifecycle, encompassing development, deployment, monitoring, and maintenance. As organizations increasingly adopt machine learning models to derive actionable insights and automate decision-making, MLOps becomes indispensable for ensuring efficiency, scalability, and reliability in ML workflows. This abstract explores the challenges encountered in implementing MLOps and presents strategies to overcome these hurdles.The challenges in MLOps can be categorized into technical, organizational, and cultural aspects. Technical challenges include model versioning, reproducibility, and ensuring consistent performance across diverse environments. Organizational challenges involve collaboration between cross-functional teams, managing diverse tools and frameworks, and integrating ML workflows with existing software development processes. Cultural challenges encompass resistance to change, skill gaps, and the need for a shared understanding of ML concepts among stakeholders.To address these challenges, a multifaceted strategy is proposed. Implementing robust version control systems and containerization techniques can enhance model reproducibility and deployment consistency. Cross-functional collaboration can be fostered through the establishment of dedicated MLOps teams, emphasizing communication and knowledge sharing. The integration of MLOps into existing DevOps practices can streamline workflows and mitigate organizational silos.Furthermore, the adoption of automated testing, continuous integration, and continuous deployment practices specific to ML can bolster the reliability of ML systems. Education and upskilling programs can bridge skill gaps, while promoting a culture of continuous learning and adaptability. Open-source MLOps tools and frameworks contribute to standardization and interoperability, facilitating smoother integration into diverse ecosystems.

 

In conclusion, the successful implementation of MLOps is crucial for organizations seeking to harness the full potential of machine learning. By addressing technical, organizational, and cultural challenges through a comprehensive strategy, businesses can establish resilient and efficient MLOps pipelines, paving the way for sustainable and scalable deployment of machine learning models.
Pulsing Effect of Sucrose and Sodium Hypochlorite on Vase Life of Cut Chrysanthemum cv Arcticqueen Flower
Authors: Nirmala A. , Rao A. Manohar , Prasanth P. , vijayalakshmi M. , Reddy S. Narendar , Srinivasachary D.
Published: January 2024

An experiment was executed to investigate the role of different concentrations of sucrose and sodium hypochlorite as pulsing solution on post harvest storage life and other characteristics of cut chrysanthemum cv Arctic queen flower after harvest. The experiment was framed as completely randomized design with factorial concept with three levels of sucrose (5, 10, 20 %) and with 50 ppm NaOCl with 3 replications. The output of the experiment revealed that flower weight (8.26 g), water uptake (13.76 g), fresh weight change (123.76g), and maximum vase life (10.23 days) was achieved in 10% sucrose for 4 hrs pulsing treatment.
Effect of Indigenous Bee Attractants on Bee Visitation and Seed Production of Sesame (Sesamum indicum Linnaeus)
Authors: Kaur Jaspreet , Kaur Gurleen , Bajaj Kavita , Singh Akashdeep , Singh Rajandeep , Kaur Navdeep
Published: January 2024

An experiment to determine the effect of various bee attractants on bee visitation and quantitative parameters in sesame crops was conducted during the kharif season in Amritsar, Punjab. The 10% concentration of each bee attractant (honey solution, jaggary solution, sugar solution, sugar+jaggary solution, and glucon-D+milk powder) was sprayed twice at 10 and 50% flowering of the crop, and bee visitation (no. of bees/5 minutes/m2 area) was recorded three times a day at 0800, 1100 and 1400 hrs. After the first spray, a gradual increase in bee visitation was recorded from 1st to 5th day of observation, whereas after the second spray, bee visitation increased till 2nd day followed by a steady decline afterwards. The bee species, including Apis mellifera, Apis cerana, Apis dorsata and Megachile lanata, were observed at a maximum on plots sprayed with honey solution (4.49±0.49, 3.91±0.39, 3.17±0.28, 3.59±0.25 bees/m2/5 min, respectively), followed by jaggary solution, sugar solution, sugar+jaggary solution, and glucon-D+milk powder. Among the quantitative parameters, the maximum number of capsules per plant (141.86±0.93), seeds per capsule (68.80±0.15), test weight (4.22±0.12 g), and seed yield (5.99 q/ha) were recorded with honey solution.
OPTIMALISASI PRESTASI AKADEMIK MELALUI PENDEKATAN INQUIRY LEARNING TERHADAP PENINGKATAN CAPAIAN PEMBELAJARAN MATEMATIKA DI KELAS 3 SD/MI
Authors: FAJRIYATI NAHDIYAH ATIKA CAHYA , CHAIRY ACH. , VOLTA ARIF SURYA
Published: January 2024

Penelitian ini mengeksplorasi penerapan model pembelajaran kooperatif berbasis inquiry pada mata pelajaran matematika kelas 3 SD/MI. Pendidikan di tingkat dasar memegang peran penting dalam membentuk dasar kognitif dan keterampilan siswa. Metode Inquiry Learning menawarkan pendekatan interaktif yang dapat meningkatkan pemahaman konsep matematika, keterampilan berpikir kritis, dan kemampuan problem-solving siswa. Metode penelitian yang digunakan adalah penelitian tindakan kelas di SD Al’Qur’an Minhajuth Thullab Pekalongan. Data dikumpulkan melalui observasi, wawancara, dokumentasi, dan evaluasi hasil belajar siswa. Analisis data menggunakan teknik deskriptif kualitatif dan komparatif. Hasil penelitian menunjukkan peningkatan signifikan dalam manajemen pembelajaran guru, aktivitas siswa, dan respon positif terhadap pembelajaran. Hasil belajar siswa juga meningkat, mencapai tingkat ketuntasan belajar secara klasikal sebesar 81,25%. Pembahasan hasil menyoroti keberhasilan model pembelajaran kooperatif berbasis inquiry dalam menciptakan lingkungan pembelajaran yang aktif, menyenangkan, dan fokus pada materi. Hasil penelitian ini memberikan implikasi terhadap pengembangan strategi pembelajaran yang lebih efektif dan dapat menjadi referensi bagi pengambil kebijakan pendidikan, guru, dan peneliti. Kesimpulannya, model pembelajaran kooperatif berbasis inquiry efektif meningkatkan pembelajaran matematika kelas 3 SD/MI. Implikasinya mencakup penerapan luas model ini dalam konteks pendidikan matematika dan pengembangan strategi pembelajaran yang adaptif.
Prevalence of Urinary Schistosomiasis Among Primary School Pupils in Keffi Local Government Area, Nasarawa State
Authors: Ndubuisi John , Yin'Allah M. V.
Published: January 2024

Schistosomiasis, also known as bilharziasis or snail fever is primarily a tropical parasitic disease caused by eggs of adult stages of Schistosoma haematobium. Schistosomiasis has significant economic and public health consequences in many tropical and subtropical countries. This research aimed to determine the prevalence of urinary schistosomiasis among pupils of primary schools in Keffi LGA. A survey of S. haematobium was carried out among primary school pupils between the ages of 4 - 12 years in three primary schools that were selected randomly. A Questionnaire was administered to obtain demographic data. A total of 250 urine samples were examined, comprising 152 from males and 98 from females.  The sedimentation technique was used, and urine deposits were examined microscopically. The overall prevalence of infection with Schistosoma haematobium in this study was 31.6%. Prevalence of disease varied among different schools, with the highest prevalence recorded at NSUK Demonstration School (20.8%) followed by LEA Primary School GRA (7.2%) while ECWA Primary School had the least prevalence of 3.6%. Males had 20.8% while females had 10.8% prevalence about Gender. Infection prevalence based on age was recorded as highest among the 10 – 12 age group with a prevalence of 20.4%. For prevalence based on source of water, those who used well water had a prevalence of 23.2%; while for prevalence based on parent’s occupation, Farmers had the highest with 22.4%. The study confirmed the prevalence of S. haematobium in the study area.
Evaluación por criterio de recuentos de niños preescolares mexicanos. Incidencia de la edad, el sexo y la posibilidad de trastorno de lenguaje
Authors: Peñaloza Christian
Published: January 2024

Las habilidades narrativas de niños preescolares han sido evaluadas en relación con la estructura narrativa o a ciertos recursos discursivos aislados. Se han propuesto, no obstante, instrumentos para valorar dichos recursos de manera integrada; entre ellos, el Índice de Complejidad Narrativa (ICN), que se basa en criterios de dominio y no en normas de referencia. En este artículo se presenta una evaluación de narraciones con el ICN que permitió observar el desempeño narrativo de niños preescolares mexicanos en once dimensiones, además de la incidencia de la edad, el sexo y la posibilidad de un trastorno del lenguaje sobre dicho desempeño. Los resultados muestran variaciones en el dominio de las distintas dimensiones. Además, mientras no se evidencian diferencias por el sexo de los niños, sí por su edad y su condición lingüística. Esta información permite enriquecer el conocimiento sobre las habilidades narrativas de niños mexicanos, además de explorar el funcionamiento de una escala narrativa no normativa.
Gestualidad y lengua en la lengua de señas mexicana
Authors: Escobar L.-Dellamary Luis
Published: January 2024

El área de los estudios sobre gestualidad tiene importantes implicaciones para la perspectiva descriptiva de la lengua, entre ellas, que gesto y habla (o gesto y señas) forman una unidad esencial para la expresión lingüística en todos los niveles y, por lo tanto, habría que reconsiderar la adecuación descriptiva de los recursos conceptuales que asumen la división entre estos dos componentes de la comunicación. En el presente artículo, se propone la revisión de la contribución metodológica de los estudios gestuales, para presentar un breve análisis de la llamada ‘marcación de tópico’ en la LSM que muestra las ventajas de aplicar esta perspectiva y nos permite reevaluar el análisis de los recursos comunicativos de esta lengua.
HUBUNGAN IKLIM ORGANISASI DENGAN KOMITMEN PROFESI PADA GURU SMAN X
Authors: Pradani Wildan Haru
Published: January 2024

Penelitian ini bertujuan untuk melihat hubungan iklim organisasi dengan komitmen profesi pada guru SMAN X. Desain penelitian yang digunakan adalah kuantitatif dengan teknik analisis product moment. Subjek penelitian adalah seluruh guru SMAN X yang berjumlah 44 orang. Metode pengambilan sampel dalam penelitian ini menggunakan teknik sampling jenuh. Penelitian ini menggunakan skala komitmen profesi yang terdiri dari 8 item dan skala iklim organisasi yang terdiri dari 26 item. Dengan teknik pengumpulan data yang dipakai adalah teknik pengumpulan data berupa skala, yaitu skala dengan model jawaban Likert. Hasil penelitian menunjukan bahwa terdapat hubungan yang signifikan antara komitmen profesi dengan iklim organisasi pada guru SMAN X dengan nilai korelasi sebesar 0, 456 dan p= 0,002 (p<0,01). Terdapat hubungan positif antara komitmen profesi dengan iklim organisasi pada guru yang bekerja di SMAN X.
KEDEKATAN ANAK DAN IBU DALAM SUKU MINANGKABAU
Authors: Kurnia Sandra Annysa , Airlangga Cut Sarha , Hafiz Muhammad , Fadila Nurul , Maharani Puan
Published: January 2024

Minangkabau merupakan salah satu suku yang ada di Indonesia yang menggunakan sistem kekerabatan matrilineal. Sistem kekerabatan matrilineal adalah di mana anak mengikuti garis keturunan ibu.  Ibu dianggap lebih memiliki kedekatan dengan anak dibandingkan sang ayah. Hal ini dikarenakan ibu memiliki peran yang lebih besar dalam memberikan pengasuhan. Peran orang tua dalam pengasuhan dapat dipengaruhi oleh aturan adat yang dianut. Penelitian ini bertujuan untuk melihat kedekatan anak dan ibu dalam suku Minangkabau. Penelitian ini melibatkan responden sebanyak 103 orang yang bersuku Minangkabau dengan usia maksimal 27 tahun. pengumpulan data dilakukan dengan open questionnaire yang kemudian datanya diolah dengan menggunakan pendekatan analisis tematik. Hasil penelitian ini menjelaskan bahwa ibu dan anak dalam suku Minangkabau memiliki hubungan yang sangat dekat.
DUKUNGAN SOSIAL PASANGAN DAN WORK FAMILY CONFLICT PADA GURU HONORER WANITA
Authors: Frans  , Rahmi Tuti , Febriani Utari , Dita Izmi Ayuning
Published: January 2024

This research aims to determine the relationship between partner social support and work family conflict in female honorary teachers. The approach to this research is a quantitative approach using survey methods. Data were collected using a scale of partner social support and work family conflict and the data was processed using product moment correlation analysis. 84 female honorary teachers participated in this research. Based on the results of data analysis and the results of coirielation analysis with a coirielation value of around 0.585. The results of research hypothesis testing show that there is a relationship between partner social support and work family conflict in female elementary school honorary teachers.
PENGARUH BRAND IMAGE DENGAN KEPUTUSAN PEMBELIAN TERHADAP SMARTPHONE IPHONE PADA MAHASISWA DI KOTA PADANG
Authors: Iskandar Aulia Ath Thaariq , Nio Suci Rahma
Published: January 2024

Keputusan pembelian meupakan salah satu hal yang dimanfaatkan Perusahaan dalam menciptaan pemasaran di kehidupan sehari-hari. Perkembangan teknologi akan memberikan informasi yang baik terutama dalam pengenalan brand suatu produk. Brand image berperan sebagai sebagai salah satu penentu dalam keputusan pembelian oleh konsumen serta menjadi hal yang mendasar bagi produsen untuk menentukan skema marketing dan target pasar. Penelitian ini bertujuan untuk mengetahui pengaruh brand image terhadap keputusan pembelian Iphone pada mahasiswa di Kota Padang. Penelitian ini menggunakan metode kuantitatif dengan pendekatan regresi. Subjek pada penelitian ini berjumlah 272 mahasiswa Kota Padang yang memenuhi kriteria yang telah ditetapkan melalui teknik simple random sampling. Metode pengambilan data dalam penelitian ini menggunakan skala Likert.  nilai reliabilitas keputusan pembelian sebesar 0. 826 dan skala brand image dengan reliabilitas sebesar 0. 867. Analisis data menggunakan linear sederhana dengan bantuan program Statistical Package for Sciences (SPSS) 26.0 for windows memperoleh hasil uji hipotesis dengan nilai koefisien regresi = 0.284 dengan nilai signifikansi p = 0.00 (p<0.05).  Artinya terdapat pengaruh brand image terhadap keputusan pembelian produk Iphone pada mahasiswa di Kota Padang. Semakin tinggi brand image Iphone maka semakin tinggi keputusan pembelian. Kesimpulannya terdapat pengaruh brand image terhadap keputusan pembelian produk Iphone.
KONTRIBUSI FOMO (FEAR OF MISSING OUT) TERHADAP NOMOPHOBIA PADA MAHASISWA PENGGUNA MEDIA SOSIAL DI BUKITTINGGI
Authors: Achirul Ramadhan  , Yusra Zulmi
Published: January 2024

Fear of missing out (FoMO) adalah sebuah ketakutan jika mengalami kehilangan momen berharga dari individu maupun kelompok lain, dimana seseorang tidak bisa hadir didalam momen tersebut yang ditandai dengan keinginan untuk selalu terhubung dengan apa yang dilakukan oleh individu atau kelompok tersebut di internet maupun dunia maya. Fear of Missing Out menjadi masalah bagi mahasiswa yang selalu memainkan smartphone setiap harinya, sehingga hal tersebut berdampak pada kebiasaan buruk jika kebiasaan berlama-lama di depan smartphone. Yang pada akhirnya berdampak pada kebiasaan mengakses smartphone hingga tak mau jauh dari smartphone dalam keadaan apapun yang di sebut dengan nomophobia. Penelitian ini bertujuan untuk melihat kontribusi fear of missing out terhadap nomophobia pada mahasiswa pengguna media sosial di Bukittinggi. Jumlah sampel pada penelitian kali ini sebanyak 144 mahasiswa yang diambil melalui teknik incidental sampling. Skala fear of missing out dan No Mobilephone Phobia Questionnare (NMP-Q) adalah alat ukur yang digunakan, dengan analisis regresi sederhana. Berdasarkan hasil penelitian, diketahui bahwa fear of missing out berkontribusi terhadap nomophobia secara signifikan sebesar 52,5%.
KONTRIBUSI FRIENDSHIP QUALITY TERHADAP HOMESICKNESS PADA SISWA BARU PEREMPUAN DI PONDOK PESANTREN KABUPATEN AGAMA
Authors: Muthi Muthi'ah Muthmainnah , Yasmin Maya
Published: January 2024

Homesickness merupakan suatu perasaan kehilangan yang dialami oleh siswa yang terpisah dari lingkungan rumah sehingga  menyebabkan siswa kerap merindukan rumah dan tidak bisa lepas dengan suasana rumah. Homesickness menjadi masalah yang perlu diatasi pada siswa baru karena memberikan dampak negatif terhadap keberlangsungan siswa di lingkungan pesantren. Penelitian ini bertujuan untuk melihat kontribusi friendship quality terhadap homesickness pada siswi baru perempuan pada pesantren di kabupaten Agam. Teknik pengambilan sampel menggunakan teknk Cluster sampling dengan partisipan berjumlah 140 siswi baru di Kabupaten Agam. Instrument penelitian yang digunakan ialah skala homesickness dan skala Friendship quality, kedua alat ukur disusun oleh peneliti berdasarkan dimensi homesickness yang dikemukakan oleh Stroebe dan Thien,Razak, dan Jamil (2017).  Metode analisis data yang yang digunakan ialah teknik regresi linear sederhana. Hasil penelitian menunjukkan bahwa friendship quality berkontribusi terhadap homesickness dengan sumbangan efektif sebesar 12,4%. Implikasi dalam penelitian ini diperlukan untuk pihak pesantren dapat  mengelola tingkat homesickness pada siswi baru pondok pesantren dengan melakukan intervensi serta meningkatkan kualitas pertemanan melalui kegiatan poisitif  di lingkungan pesantren .
Analysis of NIH K99/R00 awards and the career progression of awardees
Authors: Woitowich Nicole C , Hengel Sarah R , Solis Christopher , Vilgalys Tauras P , Babdor Joel , Tyrrell Daniel J
Published: January 2024

Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides funding for up to 5 years. Using NIH data for the period 2006–2022, we report that ~230 K99 awards were made every year, representing up to ~$250 million annual investment. About 40% of K99 awardees were women and ~89% of K99 awardees went on to receive an R00 award annually. Institutions with the most NIH funding produced the most recipients of K99 awards and recruited the most recipients of R00 awards. The time between a researcher starting an R00 award and receiving a major NIH award (such as an R01) ranged between 4.6 and 7.4 years, and was significantly longer for women, for those who remained at their home institution, and for those hired by an institution that was not one of the 25 institutions with the most NIH funding. Shockingly, there has yet to be a K99 awardee at a historically Black college or university. We go on to show how K99 awardees flow to faculty positions, and to identify various factors that influence the future success of individual researchers and, therefore, also influence the composition of biomedical faculty at universities in the United States.
RIM-BP2 regulates Ca2+ channel abundance and neurotransmitter release at hippocampal mossy fiber terminals
Authors: Miyano Rinako , Sakamoto Hirokazu , Hirose Kenzo , Sakaba Takeshi
Published: January 2024

Synaptic vesicles dock and fuse at the presynaptic active zone (AZ), the specialized site for transmitter release. AZ proteins play multiple roles such as recruitment of Ca
2+
channels as well as synaptic vesicle docking, priming and fusion. However, the precise role of each AZ protein type remains unknown. In order to dissect the role of RIM-BP2 at mammalian cortical synapses having low release probability, we applied direct electrophysiological recording and super-resolution imaging to hippocampal mossy fiber terminals of RIM-BP2 KO mice. By using direct presynaptic recording, we found the reduced Ca
2+
currents. The measurements of EPSCs and presynaptic capacitance suggested that the initial release probability was lowered because of the reduced Ca
2+
influx and impaired fusion competence in RIM-BP2 KO. Nevertheless, larger Ca
2+
influx restored release partially. Consistent with presynaptic recording, STED microscopy suggested less abundance of P/Q-type Ca
2+
channels at AZs deficient in RIM-BP2. Our results suggest that the RIM-BP2 regulates both Ca
2+
channel abundance and transmitter release at mossy fiber synapses.
A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation
Authors: Ascencao Carolline F. R. , Sims Jennie R. , Dziubek Alexis , Comstock William , Fogarty Elizabeth A. , Badar Jumana , Freire Raimundo , Grimson Andrew , Weiss Robert S. , Cohen Paula E. , Smolka Marcus
Published: January 2024

Meiotic sex chromosome inactivation (MSCI) is a critical feature of meiotic prophase I progression in males. While the ATR kinase and its activator TOPBP1 are key drivers of MSCI within the specialized sex body (SB) domain of the nucleus, how they promote silencing remains unclear given their multifaceted meiotic functions that also include DNA repair, chromosome synapsis and SB formation. Here we report a novel mutant mouse harboring mutations in the TOPBP1-BRCT5 domain.

Topbp1
B5/B5

males are infertile, with impaired MSCI despite displaying grossly normal events of early prophase I, including synapsis and SB formation. Specific ATR-dependent events are disrupted including phosphorylation and localization of the RNA:DNA helicase Senataxin.

Topbp1
B5/B5

spermatocytes initiate, but cannot maintain ongoing, MSCI. These findings reveal a non-canonical role for the ATR-TOPBP1 signaling axis in MSCI dynamics at advanced stages in pachynema and establish the first mouse mutant that separates ATR signaling and MSCI from SB formation.
Metabolomics Identifies and Validates Serum Androstenedione as Novel Biomarker for Diagnosing Primary Angle Closure Glaucoma and Predicting the Visual Field Progression
Authors: Li Shengjie , Ren Jun , Qiu Yichao , Jiang Zhendong , Shao Mingxi , Li Yingzhu , Wu Jianing , Song Yunxiao , Sun Xinghuai , Gao Shunxiang , Cao Wenjun
Published: January 2024

Primary angle closure glaucoma (PACG) is the leading cause of irreversible blindness in Asia, and no reliable, effective diagnostic, and predictive biomarkers are used in clinical routines. A growing body of evidence shows metabolic alterations in patients with glaucoma. we aimed to develop and validate potential metabolite biomarkers to diagnose and predict the visual field progression of PACG.Here, we used a 5-phases (discovery phase, validation phase 1, validation phase 2, supplementary phase, and cohort phase) multicenter (EENT hospital, Shanghai Xuhui central hospital), cross-sectional, prospective cohort study design to perform widely-targeted metabolomics and chemiluminescence immunoassay to determine candidate biomarkers. Five machine learning (random forest, support vector machine, lasso, K-Nearest neighbor, and Gaussian NB) approaches were used to identify an optimal algorithm. The discrimination ability was evaluated using the area under the receiver operating characteristic curve (AUC). Calibration was assessed by Hosmer-Lemeshow tests and calibration plots.Studied serum samples were collected from 616 participants, and 1464 metabolites were identified. Machine learning algorithm determines that androstenedione exhibited excellent discrimination and acceptable calibration in discriminating PACG across the discovery phase (discovery set 1, areas under the receiver operating characteristic curve [AUC] =1.0 [95%CI, 1.00-1.00]; discovery set, AUC=0.85 [95%CI, 0.80-0.90]) and validation phases (internal validation, AUC=0.86 [95%CI, 0.81-0.91]; external validation, AUC=0.87 [95%CI, 0.80-0.95]).Androstenedione also exhibited a higher AUC (0.92-0.98) to discriminate the severity of PACG. In the supplemental phase, serum androstenedione levels were consistent with those in aqueous humor (r=0.82, P=0.038) and significantly (P=0.021) decreased after treatment. Further, cohort phase demonstrates that higher baseline androstenedione levels (hazard ratio=2.71 [95% CI: 1.199-6.104], P=0.017) were associated with faster visual field progression.Our study identifies serum androstenedione as a potential biomarker for diagnosing PACG and indicating visual field progression.
Formation of malignant, metastatic small cell lung cancers through overproduction of cMYC protein in TP53 and RB1 depleted pulmonary neuroendocrine cells derived from human embryonic stem cells
Authors: Chen Huanhuan Joyce , Gardner Eric E , Shah Yajas , Zhang Kui , Thakur Abhimanyu , Zhang Chen , Elemento Olivier , Varmus Harold
Published: January 2024

We recently described our initial efforts to develop a model for small cell lung cancer (SCLC) derived from human embryonic stem cells (hESCs) that were differentiated to form pulmonary neuroendocrine cells (PNECs), a putative cell of origin for neuroendocrine-positive SCLC. Although reduced expression of the tumor suppressor genes
TP53
and
RB1
allowed the induced PNECs to form subcutaneous growths in immune-deficient mice, the tumors did not display the aggressive characteristics of SCLC seen in human patients. Here we report that the additional, doxycycline-regulated expression of a transgene encoding wild-type or mutant cMYC protein promotes rapid growth, invasion, and metastasis of these hESC-derived cells after injection into the renal capsule. Similar to others, we find that the addition of cMYC encourages the formation of the SCLC-N subtype, marked by high levels of
NEUROD1
RNA. Using paired primary and metastatic samples for RNA sequencing, we observe that the subtype of SCLC does not change upon metastatic spread and that production of NEUROD1 is maintained. We also describe histological features of these malignant, SCLC-like tumors derived from hESCs and discuss potential uses of this model in efforts to control and better understand this recalcitrant neoplasm.
Spatial and temporal pattern of structure-function coupling of human brain connectome with development
Authors: Feng Guozheng , Wang Yiwen , Huang Weijie , Chen Haojie , Cheng Jian , Shu Ni
Published: January 2024

Brain structural circuitry shapes a richly patterned functional synchronization, supporting for complex cognitive and behavioural abilities. However, how coupling of structural connectome (SC) and functional connectome (FC) develops and its relationships with cognitive functions and transcriptomic architecture remain unclear. We used multimodal magnetic resonance imaging data from 439 participants aged 5.7 to 21.9 years to predict functional connectivity by incorporating intracortical and extracortical structural connectivity, characterizing SC-FC coupling. Our findings revealed that SC-FC coupling was strongest in the visual and somatomotor networks, consistent with evolutionary expansion, myelin content, and functional principal gradient. As development progressed, SC-FC coupling exhibited heterogeneous alterations dominated by an increase in cortical regions, broadly distributed across the somatomotor, frontoparietal, dorsal attention, and default mode networks. Moreover, we discovered that SC-FC coupling significantly predicted individual variability in general intelligence, mainly influencing frontoparietal and default mode networks. Finally, our results demonstrated that the heterogeneous development of SC-FC coupling is positively associated with genes in oligodendrocyte-related pathways and negatively associated with astrocyte-related genes. This study offers insight into the maturational principles of SC-FC coupling in typical development and developmental disorders.
Intelligent search system for resume and labor law
Authors: Nguyen Hien , Pham Vuong , Ngo Hung Q. , Huynh Anh , Nguyen Binh , Machado José
Published: January 2024

Labor and employment are important issues in social life. The demand for online job searching and searching for labor regulations in legal documents, particularly regarding the policy for unemployment benefits, is essential. Nowadays, each function has some programs for its working. However, there is no program that combines both functions. In practice, when users seek a job, they may be unemployed or want to transfer to another work. Thus, they are required to search for regulations about unemployment insurance policies and related information, as well as regulations about workers working smoothly and following labor law. Ontology is a useful technique for representing areas of practical knowledge. This article proposes an ontology-based method for solving labor and employment-related problems. First, we construct an ontology of job skills to match curriculum vitae (CV) and job descriptions (JD). In addition, an ontology for representing labor law documents is proposed to aid users in their search for legal labor law regulations. These ontologies are combined to construct the knowledge base of a job-searching and labor law-searching system. In addition, this integrated ontology is used to study several issues involving the matching of CVs and JDs and the search for labor law issues. A system for intelligent resume searching in information technology is developed using the proposed method. This system also incorporates queries pertaining to Vietnamese labor law policies regarding unemployment and healthcare benefits. The experimental results demonstrate that the method designed to assist job seekers and users searching for legal labor documents is effective.
Unidirectional hybridization between American paddlefish Polyodon spathula (Walbaum, 1792) and sterlet Acipenser ruthenus (Linnaeus, 1758)
Authors: Káldy Jenő , Fazekas Georgina , Kovács Balázs , Molnár Mariann , Lázár Bence , Pálinkás-Bodzsár Nóra , Ljubobratović Uroš , Fazekas Gyöngyvér , Kovács Gyula , Várkonyi Eszter
Published: January 2024

Interspecific hybridizations among sturgeon species are feasible and often bidirectional. The American paddlefish (Polyodon spathula) from Family Polyodontidae and sturgeon species from Family Acipenseridae were reported capable of hybridization, but viable hybrids have been described only in crosses with the American paddlefish as paternal parents. In the reciprocal cross, the hybrids were not viable however embryos start to develop and reach late gastrula and early neurula stages. The goal of this study was to examine the hybridization between the sterlet sturgeon (Acipenser ruthenus) and the American paddlefish. Hybrid and purebred crosses were produced by artificial fertilization. Viable hybrid offspring were harvested (three month old) and verified in the families produced by female sterlet crossing with male American paddlefish. In the reciprocal hybrid crosses with female American paddlefish and male sterlet, the embryos development did not pass over 120 h post fertilization, indicating the unidirectional hybridization between American paddlefish and sterlet. Chromosome counting showed for the same ploidy level of viable hybrid and parent species. Analysis of three microsatellite markers confirmed the unidirectional hybridization between the American paddlefish and the sterlet species. Overall, the inferred genetic cause suggests that unidirectional hybridization between American paddlefish and sterlet may be the case not only for these two species but likely also between American paddlefish and other sturgeon species.
Effects of aspirin consumption during pregnancy on pregnancy outcomes: Meta‐analysis
Authors: Kozer Eran , Costei Adriana Moldovan , Boskovic Rada , Nulman Irena , Nikfar Shekoufeh , Koren Gideon
Published: April 2003

BACKGROUND: We assessed the effects and safety of aspirin treatment during pregnancy on fetal and neonatal outcomes. METHODS: We searched MEDLINE (1966–2001), EMBASE (1980–2000), TOXLINE (1994–2000), EBM Cochrane Database of Systematic Reviews (1991–2000), Reproductive Toxicology (2001), teratology texts, and bibliographies of all the included studies. We looked for published randomized controlled studies reporting aspirin treatment to improve outcomes of moderate‐ and high‐risk pregnancies. The key words used to search for articles about exposure to aspirin were salicylic acid, pregnancy, and pregnancy complications; key words used to search for outcome were neonatal diseases and abnormalities. Based on our search strategy, 1904 citations were identified; their titles and abstracts were reviewed by one reviewer. Of these citations, 182 papers were selected for detailed review. Two reviewers independently determined whether a study should be included in the final analysis. In cases of disagreement, the decision was based on the assessment of a third reviewer. RESULTS: Data were extracted independently by each reviewer. We calculated the pooled relative risk (RR) or weighted mean difference and 95% confidence intervals (CI), assuming a random‐effect model. Thirty‐eight studies met the inclusion criteria. The risk for miscarriage did not differ between women treated with aspirin and placebo (seven studies; RR, 0.92; 95% CI, 0.71–119). Women who took aspirin had a significantly lower risk of preterm delivery than did those treated with placebo (22 studies; RR, 0.92; 95% CI, 0.86–0.98). There was no significant difference in perinatal mortality (20 studies; RR, 0.92; 95% CI, 0.81–1.05) and in the rate of small‐for‐gestational‐age infants (12 studies; RR, 0.96; 95% CI, 0.87–1.07) among offspring of mothers treated with aspirin and those of mothers treated with a placebo. CONCLUSION: For women with moderate‐ and high‐risk pregnancies, aspirin treatment seemed to have a small but significant effect on reducing the rate of preterm deliveries, but did not reduce the rate of perinatal death. Birth Defects Research (Part B) 68:70–84, 2003. © 2003 Wiley‐Liss, Inc.
Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development
Authors: Cappon G. D. , Gupta U. , Cook J. C. , Tassinari M. S. , Hurtt M. E.
Published: April 2003

BACKGROUND: A review of the nonsteroidal anti‐inflammatory drug (NSAID) literature suggested occurrences of low‐level incidences of cardiovascular and midline defects in rabbit fetuses exposed in utero. Aspirin (acetylsalicylic acid, ASA) is a widely used NSAID that irreversibly inhibits cyclooxygenases (COXs) 1 and 2. ASA has been studied extensively in rats and has consistently increased low‐incidence cardiovascular malformations and defects in midline closure. The objectives of the current study were to comprehensively define the developmental toxicology profile of ASA in rabbits by using a dosing paradigm encompassing the period of organogenesis and to test the hypothesis that maternal gastrointestinal toxicity after repeated dose administrations hampers the detection of low‐incidence malformations with ASA in rabbits by limiting ASA administration to sensitive windows for cardiovascular development and midline closure. METHODS: ASA was administered to pregnant New Zealand White rabbits from gestation days (GDs) 7 to 19 at dose levels of 125, 250, and 350 mg/kg per day and as single doses of 500, 750, or 1000 mg/kg on GD 9, 10, or 11. Cesarean sections were performed on GD 29, and the fetuses were examined for external, visceral, and skeletal development. RESULTS: In the repeated dose study, maternal toxicity was exhibited in the 250‐ and 350‐mg/kg per day groups by mortality and decreased food consumption and body weight gain. In the single dose studies, maternal toxicity was exhibited at all doses by reductions in body weight gain and food consumption for 3 days after treatment. Fetal body weight was significantly reduced in the repeated dose study at 350 mg/kg per day. Fetal weights were not affected by single doses of ASA on GD 9, 10, or 11. There were no treatment‐related external, visceral, or skeletal malformations associated with ASA administration throughout organogenesis or with single doses administered during critical developmental windows. CONCLUSION: These findings supported previous work demonstrating that ASA is not teratogenic in rabbits, as opposed to rats, even when large doses are administered on single days during specific windows of development. Birth Defects Research (Part B) 68:38–46, 2003. © 2003 Wiley‐Liss, Inc.