bluuebunny/crossref_metadata_2025 huggingface dataset:
Coming back for more: factors linked to higher participation among Veterans with chronic pain in an innovative VA-YMCA wellness clinic
Authors: Preddie Alaina K , Donnelly Claire E , Miech Edward J , Myers Laura J , Williams Linda S , Damush Teresa M
Published: January 2024

In 2019, the Indianapolis VA developed a Wellness Clinic in partnership with the Young Men’s Christian Associations (YMCA) to comprehensively address Veterans’ chronic pain. Our specific aims were twofold: (1) to evaluate the implementation of the Veterans Health Indiana (VHI) Wellness Clinic on patient utilisation and (2) to evaluate patient functioning.

We conducted a mixed-methods evaluation, which included the extraction of VA administrative data to identify a patient cohort; the conduct of chart review to extract clinic utilisation, clinical outcomes collected during pain-related healthcare services and comorbidities; and semistructured interviews with Veteran patients who used the VHI Wellness Clinic in different patterns to identify challenges and facilitators to clinic utilisation. We applied configurational analysis to a Veteran sample who had their first visit to the VHI Wellness Clinic in March/April 2019 to pinpoint difference-making factors linked to Veterans’ successful participation.

The cohort included 312 Veterans (83% male), mean age of 55.4 years. The configurational model included six factors: participation in physical therapy, pain psychology or pain education sessions (22%); presence of any ‘no-shows’ (57% had 0); history of depression (39%) and clinic referral source (51% self-referred from primary care). The model consisted of four different pathways to successful participation, explaining 60% of cases in the higher-participation group with 86% consistency. Patient outcomes after clinic utilisation demonstrated a significant reduction in self-reported pain and pain catastrophising across time. Moreover, patients reported distance to clinic as both a facilitator and challenge.

This mixed-methods analysis identified specific biopsychosocial factors and clinical services directly linked to higher Veteran participation in a new VA-YMCA Wellness Clinic. The VHI Wellness Clinic embedded within a YMCA facility is a feasible and efficacious healthcare delivery model for primary care patients experiencing chronic pain. Additional marketing to clinical providers for referrals and to patients to extend its reach is needed.
Mental Health Admissions to Paediatric Wards Study (MAPS): a protocol for the analysis of Hospital Episode Statistics (HES) data
Authors: Hudson Lee Duncan , Ward Joseph , Vázquez-Vázquez Adriana , Settle Kate , Cornaglia Francesca , Gibson Faith , Phillips Kirsty , Mathews Gabrielle , Roberts Helen , Roland Damian , Nicholls Dasha E , Elphinstone Holly , Viner Russell
Published: January 2024

Introduction

Children and young people (CYP) presenting with a mental health (MH) crisis are frequently admitted to general acute paediatric wards as a place of safety. Prior to the pandemic, a survey in England showed that CYP occupied 6% of general paediatric inpatient beds due to an MH crisis, and there have been longstanding concerns about the quality of care to support these patients in this setting. Mental Health Admissions to Paediatric Wards Study aims to generate a theory of change (ToC) model to improve the quality of care for CYP admitted to acute paediatric services after presenting in a MH crisis.

Methods and analysis

We will undertake a national (England), sequential, mixed methods study to inform a ToC framework alongside a stakeholder group consisting of patients, families/carers and healthcare professionals (HCPs). Our study consists of four work packages (WP) undertaken over 30 months. WP1 is limited to using national routine administrative data to identify and characterise trends in MH admissions in acute paediatric wards in England between 2015– 2022.

Ethics and dissemination

WP1 received ethical approval (Ref 23/NW/0192). We will publish the overall synthesis of data and the final ToC to improve care of CYP with MH crisis admitted to general acute paediatric settings. As coproducers of the ToC, we will work with our stakeholder group to ensure wide dissemination of findings. Potential impacts will be on service development, new models of care, training and workforce planning.
Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial
Authors: Cheng Xin , Hong Lan , Churilov Leonid , Lin Longting , Ling Yifeng , Zhang Jin , Yang Jianhong , Geng Yu , Wu Danhong , Liu Xueyuan , Zhou Xiaoyu , Zhao Yuwu , Zhai Qijin , Zhao Liandong , Chen Yangmei , Guo Ying , Yu Xiaofei , Gong Fan , Sui Yi , Li Gang , Yang Lumeng , Gu Hong-Qiu , Wang Yilong , Parsons Mark , Dong Qiang
Published: January 2024

Background

The performance of intravenous tenecteplase in patients who had an acute ischaemic stroke with large/medium vessel occlusion or severe stenosis in an extended time window remains unknown. We investigated the promise of efficacy and safety of different doses of tenecteplase manufactured in China, in patients who had an acute ischaemic stroke with large/medium vessel occlusion beyond 4.5-hour time window.

Methods

The CHinese Acute tissue-Based imaging selection for Lysis In Stroke-Tenecteplase was an investigator-initiated, umbrella phase IIa, open-label, blinded-endpoint, Simon’s two-stage randomised clinical trial in 13 centres across mainland China. Participants who had salvageable brain tissue on automated perfusion imaging and presented within 4.5–24 hours from time of last seen well were randomised to receive 0.25 mg/kg tenecteplase or 0.32 mg/kg tenecteplase, both with a bolus infusion over 5–10 s. The primary outcome was proportion of patients with promise of efficacy and safety defined as reaching major reperfusion without symptomatic intracranial haemorrhage at 24–48 hours after thrombolysis. Assessors were blinded to treatment allocation. All participants who received tenecteplase were included in the analysis.

Results

A total of 86 patients who had an acute ischaemic stroke identified with anterior large/medium vessel occlusion or severe stenosis were included in this study from November 2019 to December 2021. All of the 86 patients enrolled either received 0.25 mg/kg (n=43) or 0.32 mg/kg (n=43) tenecteplase, and were available for primary outcome analysis. Fourteen out of 43 patients in the 0.25 mg/kg tenecteplase group and 10 out of 43 patients in the 0.32 mg/kg tenecteplase group reached the primary outcome, providing promise of efficacy and safety for both doses based on Simon’s two-stage design.

Discussion

Among patients with anterior large/medium vessel occlusion and significant penumbral mismatch presented within 4.5–24 hours from time of last seen well, tenecteplase 0.25 mg/kg and 0.32 mg/kg both provided sufficient promise of efficacy and safety.

Trial registration number

ClinicalTrials.gov Registry (
NCT04086147
,
https://clinicaltrials.gov/ct2/show/NCT04086147
).
Discontinuation of antiplatelet therapy after stent-assisted coil embolisation of cerebral aneurysm: a nationwide cohort study
Authors: Baik Minyoul , Jeon Jimin , Kim Jinkwon , Yoo Joonsang
Published: January 2024

Introduction

Stent-assisted coil embolisation (SACE) for the treatment of unruptured cerebral aneurysms has been increasingly used. Long-term advantages of antiplatelet therapy (APT) post-SACE treatment are still not well understood. We investigated the long-term effects of APT on clinical prognosis after SACE.

Patients and methods

We conducted a retrospective study using nationwide health insurance claims data from South Korea, including patients with cerebral aneurysm treated with SACE from January 2009 to December 2020. The study outcomes consisted of the occurrence of cerebral infarction and major haemorrhage. To evaluate the impact of APT, we employed a multivariable time-dependent Cox proportional hazards regression model for each of the three distinct periods: 1–12 months, 12–24 months and >24 months after SACE.

Results

This study included 17 692 unruptured cerebral aneurysm patients treated with SACE. During the mean follow-up of 4.2 years, there were 379 (2.1%) patients with cerebral infarction and 190 (1.1%) patients with major haemorrhage. The percentage of patients receiving APT was 79.5% at 1 year, which gradually decreased to 58.3% at 2 years after SACE. APT was beneficial in preventing cerebral infarction within 12 months after SACE (adjusted HR (aHR) 0.56; 95% CI, 0.35 to 0.89; p=0.014). After 12 months, this association was not evident. APT increased the risk of haemorrhage after 24 months (aHR 1.76; 95% CI 1.11 to 2.87; p=0.016).

Discussion and conclusion

Our findings suggest that in patients with unruptured cerebral aneurysm treated with SACE, the reasonable duration of APT for preventing cerebral infarction might be 1 year after SACE.
Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE): rationale and design of a multicentre, prospective, randomised, open-label, blinded-endpoint, controlled phase 3 non-inferiority trial
Authors: Li Shuya , Gu Hong-Qiu , Dai Hongguo , Lu Guozhi , Wang Yongjun
Published: January 2024

Background and purpose

Reteplase is the third generation of alternative thrombolytic agent. We hypothesis that reteplase will be non-inferior to alteplase in achieving excellent functional outcome at 90 days among eligible patients with acute ischaemic stroke.

Methods and design

Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE) trial is a multicentre, prospective, randomised, open-label, blinded endpoint (PROBE), controlled phase 3 non-inferiority trial. A total of 1412 eligible patients will be randomly assigned to receive either reteplase at a dose of 18 mg+ 18 mg or alteplase 0.9 mg/kg at a ratio of 1:1. An independent data monitoring committee will review the trail’s progress and safety data.

Study outcomes

The primary efficacy outcome of this study is proportion of individuals attaining an excellent functional outcome, defined as modified Rankin Scale (mRS) 0–1 at 90 days. The secondary efficacy outcomes encompass favourable functional outcome defined as mRS 0–2, major neurological improvement on the National Institutes of Health Stroke Scale, ordinal distribution of mRS and Barthel Index score of at least 95 points at 90 days. The primary safety outcomes are symptomatic intracranial haemorrhage at 36 hours within 90 days.

Discussion

The RAISE trial will provide crucial insights into the selection of thrombolytic agents for stroke thrombolysis.

Trial registration number

NCT05295173
.
On Klein–Gordon Gürses oscillators and pseudo-Gürses oscillators: Vorticity–energy correlations and spacetime-associated degeneracies
Authors: Mustafa Omar
Published: January 2024

In this paper, we discuss Klein–Gordon (KG) oscillators in the [Formula: see text]-dimensional Gürses spacetime and under position-dependent mass (PDM) settings. We observe that the KG Gürses oscillators are introduced as a byproduct of the very nature of the Gürses spacetime structure. We report that the energy levels of such KG Gürses oscillators admit vorticity–energy correlations as well as spacetime-associated degeneracies (STADs). Moreover, we introduce a new set of KG pseudo-Gürses oscillators that admits isospectrality and invariance with the KG Gürses oscillators and inherits the same vorticity–energy correlations as well as STADs.
A special case on the distillability problem of two-copy n×n Werner states
Authors: Chen Huilin
Published: January 2024

In this paper, we delve into a nuanced aspect of the distillability problem within the realm of entanglement theory, specifically examining the distillability of anti-diagonal [Formula: see text] entangled Werner states under the framework of local operations and classical communication (LOCC). To address this, we scrutinize a conjecture central to the distillability issue, initially focusing on its implications in 4-dimensional and 5-dimensional contexts. Through rigorous calculations, we establish that these cases align with the conjecture. Subsequently, we broaden our investigation to encompass [Formula: see text] matrices, demonstrating that both even and odd n-dimensional anti-diagonal matrices are in concordance with the conjecture, thus contributing to a deeper understanding of the distillability problem in quantum entanglement.
FRACTAL STUDY ON THE PERMEABILITY IN CHARGED MICRO-FRACTURED POROUS MEDIA
Authors: LIU WENYAN , DUAN YUZENG , XIAO BOQI , LUO LIANG , ZOU MINGQING , LIANG MINGCHAO
Published: January 2024

Fractured porous media is of great significance to the exploration and development of unconventional reservoirs. In this paper, a fractal model for permeability through micro-fractured porous media with consideration of the electric double layer (EDL) effect is proposed based on the fractal theory. The present model indicates that the permeability is a function of the electrokinetic parameters and micro-structural parameters of fractured porous media, and each parameter has a clear physical meaning, the results from the proposed model are found to be in good agreement with experimental data. Moreover, factors influencing the permeability are also analyzed in detail. The results indicate that the more obvious EDL effects will lead to permeability becoming lower. The present fractal model for the permeability with the EDL effect can provide guidance for tight reservoir development or other micro-porous media transportation.
An introduction to the Bowland Shale Formation, UK: processes and resources
Authors: Emmings J. F. , Parnell J. , Stephenson M. H. , Lodhia B. H.
Published: January 2024

This volume showcases recent geological, geophysical and geochemical research on the Carboniferous Bowland Shale Formation. The Bowland Shale is a relatively thick and extensive Palaeozoic black shale unit with a long history of debate and controversy in the UK. The Bowland Shale is proven in many of the key Carboniferous basins in the Midlands, northern England and North Wales, and represents a significant, near-continuous temporal record spanning 16 Myr including the important mid-Carboniferous boundary (Mississippian–Pennsylvanian). Since the first geological surveys in the late nineteenth century, the Bowland Shale has been of interest for a variety of reasons, including the search for Irish-type Pb–Zn base metal mineral deposits, and as a source rock in conventional hydrocarbon systems. In the mid-2000s, attention turned to the Bowland Shale as a target for unconventional hydrocarbon extraction, shale gas, following success in the USA. This placed the Bowland Shale at the centre of a series of interconnected controversies and debates from the local to national scale. The geological credibility of the purported shale gas resource in the UK was – and continues to be – highly contentious. This volume contributes to a more updated view of the Bowland Shale, covering topics such as sedimentary, geochemical and physical properties and processes, basin-forming events, hydrocarbon prospectivity, mineralization and heat and fluid flow in the subsurface. The volume also includes a field guide to some of the key localities in the UK. With the benefit of hindsight offered by the latest generation of research, the early regional shale gas assessments failed to attach sufficient weight to the compositional heterogeneity, structural complexity, compartmentalization and highly variable exhumation, erosion and palaeo-heat flow history of the Bowland Shale. The following topics are identified as promising avenues for future research beyond shale gas: (1) the role of the Bowland Shale in the context of mineral systems; (2) the role of the Bowland Shale as a cap rock in the Lower Carboniferous limestone geothermal play and potentially as an analogue of CO
2
or radioactive waste storage in the UK; and (3) pathways and mechanisms for weathering, alteration and trace element release from the Bowland Shale into the surface and/or subsurface environment.
Complex Congenital Heart Disease in the Adult
Authors: Goldstein Sarah A. , Krasuski Richard A.
Published: January 2024

Congenital heart disease (CHD), a heterogeneous group of structural abnormalities of the cardiovascular system, is the most frequent cause of severe birth defects. Related to improved pediatric outcomes, there are now more adults living with CHD, including complex lesions, than children. Adults with CHD are at high risk for complications related to their underlying anatomy and past surgical palliative interventions. Adults with CHD require close monitoring and proactive management strategies to improve outcomes.
Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy
Authors: Mora Stephen , Adegoke Olasunkanmi A. J.
Published: January 2024

This is the first study to attenuate chemotherapy-induced myotube atrophy by manipulating a BCAA transporter. Our findings suggest that positive regulation of amino acid transporters may be a promising strategy to treat cachexia.
Colloid Systems and Interfaces Stability of Cerium Oxide Nanoparticles in Aqueous Environments: Effects of pH, Ionic Composition, and Suwanee River Humic and Fulvic Acids
Authors: Mu Linlin , Ghorbani Mahsa , Baveye Philippe C. , Darnault Christophe J. G.
Published: January 2024

This study investigates the colloid systems and interfaces stability of cerium oxide nanoparticles in aqueous environments as a function of pH, monovalent cations (Na+) and divalent cations (Ca2+), and humic substances (humic acid (HA) and fulvic acid (FA)). Results show that the solution chemistry affected the colloidal stability and aggregation kinetics of CeO2 NPs. The pH point of zero charge (pHPZC) of CeO2 NPs was measured at pH 10.2 with diameter of CeO2 NPs aggregates of ∼1,700 nm. The effects of Na+ and Ca2+ and HA and FA on the magnitudes and rates of aggregation were pH-dependent. In addition, when salts were present in the aqueous systems, although the CeO2 NPs were stable at pH < pHPZC (expect for 1 mM of NaCl/CaCl2) and pH > pHPZC (except for 0.5 mM CaCl2), the aggregation was enhanced at pH = pHPZC, with the diameter of CeO2 NPs in the ∼1,300–3,600 nm range. HA also stabilized CeO2 NPs under pH > pHPZC with an enhanced aggregation of pH = pHPZC with the diameter of CeO2 NPs in the ∼1,500–1,900 nm range, and in the presence of 0 and 1 mM of NaCl/CaCl2 at pH < pHPZC. At three pH levels (8.2, 10.2, and 12.2) and under all different electrolyte concentrations (0–1 mM of NaCl or CaCl2), FA (0.14 mg/L) exhibited a greater degree of efficiency in stabilizing CeO2 NPs than HA (5 mg/L), with CeO2 NPs aggregates growing at low rates and resulting in diameter of ∼95–115 nm.
Exploring the Coinfection and Genetic Diversity of Multiple Tick‐Borne Pathogens in Livestock Population of Punjab, Pakistan
Authors: Hussain Sabir , Hussain Abrar , Aziz Muhammad Umair , Song Baolin , Zeb Jehan , Moutailler Sara , Foucault-Simonin Angélique , Smith Rebecca L. , Cabezas-Cruz Alejandro , George David , Sparagano Olivier
Published: January 2024

Tick‐borne diseases affecting domestic animals and humans have increased globally in recent years. Pakistan, in particular, faces a significant economic threat from ticks, where two specific species, Rhipicephalus microplus and Hyalomma anatolicum, act as vectors for various pathogens such as piroplasma, Anaplasma, Ehrlichia, and Rickettsia that pose a significant burden on livestock production in the country. To better understand the risk that tick‐borne pathogens (TBPs) pose to livestock in Pakistan, we conducted a cross‐sectional study of the occurrence, diversity, and coinfection of these pathogens in small and large ruminants owned by small farms as well as in ticks collected from these animals. We collected blood samples from 224 cattle, 224 buffalo, 69 goats, and 56 sheep, gathered from 112 farms located in seven districts of Punjab, one of Pakistan’s largest province. In addition, we collected a total of 476 ticks attached to these animals. Based on the identification of tick species through morphology and sequence analysis of the 16S rRNA and cytochrome c oxidase subunit 1 (cox1) gene, we confirmed that the most commonly collected tick species were Rh. microplus (38.65% of all individuals), H. anatolicum (31.93%), and Rh. decoloratus (8.40%). Notable pathogens detected in the collected ticks included Theileria annulata (18.4% prevalence), Anaplasma ovis (15.79%), A. centrale (13.16%), and Rickettsia slovaca (13.16%). In blood samples, the most frequently detected pathogens were T. annulata (n = 8), Babesia bovis (n = 7), A. centrale (n = 6), and B. bigemina (n = 5). In some cases, both cattle and buffaloes were found to be coinfected with B. bovis, T. annulata, and A. centrale. These findings provide valuable insights into the circulation of TBPs in livestock and highlight the need for further research on the epidemiological risk that these pathogens pose to ruminants in Pakistan.
TABLE 2 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: January 2024

Univariate Cox regression model for OS, PFS, and DMFS among patients with breast cancer (World IBC Consortium dataset; n = 314)
FIGURE 4 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: January 2024

Effect of inhibition of MELK signaling on tumor growth and lung metastasis in TNBC xenograft mouse models. A, MELK expression in Cas9-p15 (P15) and MELK KO MDA-MB-231 (C3 and C28) cells. α-Tubulin was used as a loading control. B–F, MELK KO significantly suppressed lung metastases in an MDA-MB-231 xenograft mouse model. Female athymic nude mice were injected intravenously with luciferase-transfected Cas9-p15 or MELK KO MDA-MB-231-Luc-GFP stable cells. Metastatic tumors were measured weekly for 7 weeks by whole-body luciferase imaging using an IVIS 100 Imaging System. Shown are mouse whole-body luciferase images (B), photon counts per area (C), lung weight per mouse measured at week 7 following cell inoculation (D), mouse OS over a period of 80 days following cell inoculation (E), and IHC staining for hematoxylin and eosin (H&E), MELK, proliferation (Ki67), and mesenchymal markers (vimentin and fibronectin; F) in mice inoculated with Cas9-p15 or MELK KO MDA-MB-231 cells. Images were taken under 200 × magnification. G, MELK-In-17 significantly suppressed tumor growth in a 4T1 xenograft mouse model (P < 0.05). Murine 4T1 TNBC cells were injected into the mammary fat pads of female BALB/c mice. When tumor size reached 75–150 mm3, grouped mice were treated with vehicle or MELK-In-17 at 5 or 10 mg/kg via intraperitoneal injections daily for 25 days. In C–G, data are presented as mean ± SD. *, P < 0.05; **, P < 0.01.
FIGURE 1 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: January 2024

Clinical relevance of MELK in breast cancer and expression of MELK in breast cancer cell lines. A,MELK mRNA levels in HR−HER2+, HR+HER2−, HR+HER2+, and TNBC tumors in the World Consortium IBC dataset, analyzed by multiple comparison using a general linear model. Data are presented as mean ± SD. – represents median, X represents mean. B, IHC images (200× magnification) showing MELK protein expression in normal epithelial tissue and luminal, HER2+, and TNBC breast tumors. Correlation between MELK mRNA levels (<7 or ≥7) and OS, PFS, and DMFS in patients in the overall cohort (C) and among those with TNBC (D), determined by the Kaplan–Meier method. MELK mRNA levels (E) and protein levels (F) in TNBC and non-TNBC cells. Inset, correlation between MELK mRNA and protein levels in TNBC cell lines. In F, α-tubulin was used as a loading control. MELK mRNA levels were determined using quantitative reverse transcriptase PCR.
Supplemental Table 5 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Supplementary Table 5. Median Change in Biomarkers from Baseline Over Time by Tumor Response
Supplemental Figure 2 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Supplementary Figure 2. Kaplan–Meier Curve of OS 12 Months of Follow-up from the Last Patient’s First Dose (Data Cutoff Date: January 25, 2023)
Data from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

AbstractPurpose:
E7389-LF is a liposomal formulation of eribulin that contributes to tumor vascular remodeling. The phase II part of this phase Ib/II study assessed the efficacy/safety of E7389-LF in combination with nivolumab in several disease cohorts; herein, we report results from the small cell lung cancer (SCLC) cohort.
Experimental Design:
Patients with unresectable/measurable SCLC and disease progression with first-line platinum-based chemotherapy with/without an immune checkpoint inhibitor (ICI) were enrolled to receive E7389-LF 2.1 mg/m2 plus nivolumab 360 mg intravenously every 3 weeks. The primary objective of this part was to assess the objective response rate (ORR). Secondary objectives included assessments of safety and progression-free survival (PFS); exploratory assessments included overall survival (OS) and biomarkers.
Results:
Thirty-four patients were enrolled. By the data cut-off date (May 31, 2022), 29 (85.3%) had discontinued. Efficacy/biomarker analyses included 33 patients (1 had their diagnosis changed postenrollment); the ORR of E7389-LF plus nivolumab was 24.2% [95% confidence interval (CI): 11.1–42.3], the median PFS was 3.98 months (95% CI: 2.63–4.40), and, at a median follow-up of 10.6 months, the median OS was not reached (95% CI: not estimable). Notably, 27 of 33 patients (81.8%) had received an ICI as their prior first-line therapy. Treatment-related, treatment-emergent adverse events occurred in 97.1% (any grade) and 82.4% (grade ≥3) of enrolled patients; the most common event was neutropenia. Changes in vascular and immune-related plasma markers were observed.
Conclusions:
E7389-LF 2.1 mg/m2 in combination with nivolumab 360 mg every 3 weeks showed notable antitumor activity as second-line therapy for SCLC; no new safety signals were observed compared with either agent as monotherapy.
Significance:
This phase II part of a phase Ib/II study assessed liposomal eribulin (E7389-LF) plus nivolumab in 34 patients with pretreated SCLC; 8 of 33 evaluable patients (including 6/27 pretreated with ICIs) had objective responses. The combination was tolerable; increases in vasculature-related biomarkers tended to correlate with responses.
Triple Trouble with Triple Solutions: A Unique Case Report of a Severe Exudative Retinal Detachment Accompanied by Retinal Traction and Two Retinal Holes in Coats Disease
Authors: Berco Efraim , Elsliger Simon , Weinberg Tamir , Ghannam Waleed , Shoham-Hazon Nir
Published: January 2024

Introduction: Coats disease is a rare vasculature pathology that usually presents as retinal telangiectasia with possible progression to exudative retinal detachment (RD). Intravitreal anti-VEGF injections, cryotherapy, laser photocoagulation, and surgery are commonly used to control the disease and prevent its progression. Although iatrogenic tractional RDs secondary to anti-VEGF injections have been reported in patients with Coats disease, RDs in Coats disease are exudative, secondary to retinal exudation and vascular abnormalities. In this article, we present the first reported case of a severe exudative RD accompanied by retinal traction and two retinal holes in a patient with Coats disease. Case Presentation: A 32-year-old male initially presented with Coats disease stage 2A, which then progressed to 3A1 within a month of close follow-ups, finally leading to exudative RD. Following cryotherapy and bevacizumab injections, the exudative RD progressed, with the emergence of retinal traction and two retinal holes. This complex case was successfully treated with a scleral buckle vitrectomy accompanied by radial elements to support the RD, pars plana vitrectomy, silicon oil tamponade, and post-surgical bevacizumab injections. Six months following the surgical intervention, the patient’s vision is restored at 20/30, and retinal imaging shows a totally flattened retina. Conclusion: We present the first reported case of a severe exudative RD accompanied by retinal traction and two retinal holes in a patient with Coats disease. The combination of surgical treatment and bevacizumab injections is thought to have collectively contributed to our patient’s favorable outcome.
HER2-Positive Lacrimal Sac Squamous Cell Carcinoma in a 57-Year-Old Man
Authors: Grachev Nikolay , Rabaev Gavriil , Avdalyan Ashot , Znamenskiy Igor , Mosin Dmitry , Ustyuzhanin Dmitry , Rabaev Gennady , Lužbeták Martin
Published: January 2024

Introduction: Lacrimal sac squamous cell carcinoma (SCC) is a rare tumor. Only 241 cases of lacrimal sac SCC have been reported in the literature. However, the detailed molecular profile of this tumor is unknown. Case Presentation: Fifty-seven-year-old Caucasian male presented with a 6-month history of epiphora. Multimodal examination revealed a unilateral lacrimal sac SCC T4aN0M0. The patient underwent primary surgery with subsequent chemoradiotherapy. The patient was alive 18 months after the end of the treatment, with no signs of local or distant relapse. Complex molecular profiling revealed the FGFR p.G388R variant, HER2 amplification, and progression phenotype. Conclusion: Here, we describe a clinical case of a male patient with lacrimal sac SCC with a careful description of the disease history, treatment, and molecular-genetic patterns of the tumor. This is the first report of HER2-positive lacrimal sac SCC.
A new species of the genus Celaenorrhinus Hübner, [1819] from Hainan, China (Lepidoptera, Hesperiidae)
Authors: LI HUA-ZHAO , LIU ZHE , LI JIA-LING
Published: January 2024

A new species, Celaenorrhinus qianhanae Li & Liu sp. nov., is described from Hainan, China. Its unique genital characteristics and wing markings are compared with other congeneric species from this island and adjacent regions, including Vietnam and China, etc. In addition, its COI gene is sequenced for molecular analysis, and the secondary sexual character, hair tufts on hind tibiae, is discussed for comparison.
„W udręce wołałem do Pana, a On mnie wysłuchał […]. Pan moim wspomożycielem” (Ps 118[117]:5–6). O leksykalnej wariantywności psałterzowych redakcji cerkiewnosłowiańskich. Na przykładzie tłumaczeń gr. ὁ ἀντιλή(μ)πτωρ, ἡ ἀντίλη(μ)ψις, ἡ βοήθεια, ὁ βοηθός, ἡ λύτρωσις, ὁ λυτρωτής, ῥυόμενος, ὁ ῥυστής, ὁ ὑπερασπισμóς i ὁ ὑπερασπιστής. Ujęcie ilościowe
Authors: Szulc Arleta
Published: January 2024

“I called upon the Lord in distress: the Lord answered me […]. The Lord is on my side” (Ps 118[117]:5–6). On the Lexical Variation of Church Slavonic Psalter Redactions: The Case of Translations of the Greek ὁ ἀντιλή(μ)πτωρ, ἡ ἀντίλη(μ)ψις, ἡ βοήθεια, ὁ βοηθός, ἡ λύτρωσις, ὁ λυτρωτής, ῥυόμενος, ὁ ῥυστής, ὁ ὑπερασπισμóς and ὁ ὑπερασπιστής. A Quantitative Approach
This article is another one in a series of studies dealing with the lexical variation of Church Slavonic Psalter redactions. The paper focuses on the vocabulary used by man to address God as his protector, helper, saviour etc., and analyses the (Old) Church Slavonic equivalents of such Greek lexemes as ἀντιλή(μ)πτωρ, ἀντίλη(μ)ψις, βοήθεια, βοηθός, λύτρωσις, λυτρωτής, ῥυόμενος, ῥυστής, ὑπερασπισμóς and ὑπερασπιστής. It also points out the Hebrew equivalents of the investigated Greek and (O)CS words. The study concentrates on the quantitative aspect of the use of the vocabulary under discussion, with qualitative issues (semantics / contextual conditions) remaining in the background.
„W udręce wołałem do Pana, a On mnie wysłuchał […]. Pan moim wspomożycielem” (Ps 118[117]:5–6). O leksykalnej wariantywności psałterzowych redakcji cerkiewnosłowiańskich. Na przykładzie tłumaczeń gr. ὁ ἀντιλή(μ)πτωρ, ἡ ἀντίλη(μ)ψις, ἡ βοήθεια, ὁ βοηθός, ἡ λύτρωσις, ὁ λυτρωτής, ῥυόμενος, ὁ ῥυστής, ὁ ὑπερασπισμóς i ὁ ὑπερασπιστής. Ujęcie ilościowe
To kolejny artykuł w cyklu opracowań traktujących o leksykalnej wariantywności psałterzowych redakcji cs. Tym razem uwagę skupia się na grupie słownictwa, którym człowiek zwraca się do Boga jako swego protektora, pomocnika, wybawiciela etc. Analizie poddaje się użycia (s)cs. ekwiwalentów takich gr. leksemów, jak: ἀντιλή(μ)πτωρ, ἀντίλη(μ)ψις, βοήθεια, βοηθός, λύτρωσις, λυτρωτής, ῥυόμενος, ῥυστής, ὑπερασπισμóς i ὑπερασπιστής. Dodatkowo wskazuje się na odpowiedniki hebrajskie badanych słów greckich i (s)cs. W rozważaniach nacisk kładzie się na aspekt ilościowy użyć badanego słownictwa, kwestie jakościowe (semantykę / uwarunkowania kontekstu) przesuwając na plan dalszy.
Frekwencja, struktura i budowa słowotwórcza pochodnych imion osobowych występujących w funkcji zoonimów
Authors: Kijak Agnieszka
Published: January 2024

Frequency, Structure and Word-Formation Patterns of Derivatives of Personal Names Used as Zoonyms
The article is a continuation of earlier analyses of the material excerpted from a database containing a list of zoonyms in one of the veterinary clinics in the city of Poznań. The author considers the issue of personal names used as animal calls, focusing on the calls which, when used with reference to people, are derivative forms and are classified as diminutives. The study includes statistics of their frequency in the case of various animal species. The second part presents the conclusions of a word-formation analysis, which makes it possible to classify the zoonyms under discussion and determine which of the identified categories is the most numerous.
Frekwencja, struktura i budowa słowotwórcza pochodnych imion osobowych występujących w funkcji zoonimów
Artykuł stanowi kontynuację dokonanych wcześniej analiz przeprowadzonych na materiale wyekscerpowanym z bazy danych zawierającej spis zoonimów w jednej z poznańskich lecznic weterynaryjnych. Autorka podejmuje w nim problematykę imion osobowych wykorzystywanych w funkcji zawołań zwierząt. Przedmiotem zainteresowania są zawołania, które w odniesieniu do ludzi używane są jako formy pochodne i określane zdrobnieniami. W artykule zaprezentowano statystyki pokazujące ich frekwencję u różnych gatunków zwierząt. W drugiej części przedstawiono wnioski z przeprowadzonej analizy słowotwórczej pozwalającej na dokonanie podziału omawianych zoonimów i ustalenie, która z wydzielonych grup jest najliczniejsza.
Język staro-cerkiewno-słowiański: źródło inspiracji czy zbędny balast? O możliwościach wykorzystania gramatyki języka scs. w nauce współczesnych języków słowiańskich
Authors: Fałowski Przemysław
Published: January 2024

The Old Church Slavonic Language: A Source of Inspiration or an Unnecessary Burden? On the Possibilities of Using OCS Grammar in the Teaching and Learning of Modern Slavic Languages
The aim of this article was to investigate the status of the Old Church Slavonic language in the context of today’s academic didactics, especially in Slavic studies. The research aimed to test two hypotheses: (a) an Old Church Slavonic course is useful in the teaching of modern Slavic languages, (b) students of Slavic studies can see the practical dimension of a course in this language and the links between Old Church Slavonic and other Slavic languages. In the course of the analysis, both hypotheses were confirmed: it was proven that the Old Church Slavonic language course can have a practical application, and for most students this aspect of the course is important. The results of the study can be used to improve the course on the grammar of Old Church Slavonic: from the revision of the syllabus entries to specific exercises in classes with students.
Język staro-cerkiewno-słowiański: źródło inspiracji czy zbędny balast? O możliwościach wykorzystania gramatyki języka scs. w nauce współczesnych języków słowiańskich
Celem artykułu było zbadanie statusu języka staro-cerkiewno-słowiańskiego w kontekście dzisiejszej dydaktyki akademickiej, szczególnie slawistycznej. Badania miały na celu sprawdzenie dwóch hipotez: a) kurs języka staro-cerkiewno-słowiańskiego jest przydatny w nauczaniu współczesnych języków słowiańskich, b) studenci studiów slawistycznych dostrzegają praktyczny wymiar kursu tego języka oraz powiązania języka staro-cerkiewno-słowiańskiego z innymi językami słowiańskimi. W toku analizy potwierdzone zostały obie hipotezy: udowodniono, że kurs języka staro-cerkiewno-słowiańskiego może mieć praktyczne zastosowanie, a dla większości studentów ten aspekt zajęć jest istotny. Wyniki przeprowadzonych badań mogą zostać wykorzystane do udoskonalenia kursu z gramatyki języka staro-cerkiewno-słowiańskiego: począwszy od korekty zapisów w sylabusach, aż po konkretne ćwiczenia w ramach zajęć ze studentami.
Язык захватнических войн – пример социолингвистического исследования
Authors: Руденка [Rudenka] Алена [Alena]
Published: January 2024

The Language of Wars of Conquest – An Example of a Sociolinguistic Study
Review: Andreĭ Zinkevich, IAzyk i voĭna: Okkupatsionnaia iazykovaia politika v Slavii vo vremia Vtoroĭ mirovoĭ voĭny. Tribun EU, Brno 2021, 599 pp. ISBN: 978-80-263-1637-4
This article is a review of the book IAzyk i voĭna: Okkupatsionnaia iazykovaia politika v Slavii vo vremia Vtoroĭ mirovoĭ voĭny [Language and War: Language Policy in the Occupied Slavic Countries during World War II] (2021) by Andrei Zinkevich. The monograph under review is devoted to the reconstruction of the language policy in the occupied Slavic countries during the Second World War. Zinkevich defines the types of language policy in the countries under consideration and classifies their main features. His book is especially relevant today: since the beginning of the war in Ukraine, it has been read differently.
Język wojen zaborczych – przykładowe studium socjolingwistyczne
Recenzja: Андрей Зинкевич, Язык и война: Оккупационная языковая политика в Славии во время Второй мировой войны. Tribun EU, Brno 2021, 599 ss. ISBN: 978-80-263-1637-4
Artykuł jest recenzją książki Andrieja Zinkiewicza Язык и война: Оккупационная языковая политика в Славии во время Второй мировой войны [Język i wojna: Okupacyjna polityka językowa w krajach słowiańskich w czasie II wojny światowej] (2021). Recenzowana monografia została poświę­cona rekonstrukcji polityki językowej w okupowanych krajach słowiańskich w czasie II wojny światowej. Zinkiewicz definiuje typy okupacyjnej polityki językowej w omawianych krajach i klasyfikuje ich główne cechy. Recenzowana książka jest dziś szczególnie aktualna: od początku wojny w Ukrainie czyta się ją inaczej.
Spójnik zaś – przyczynek do opisu leksykalizacji struktur (wyrażeń) składniowych w polszczyźnie
Authors: Sikora Kazimierz
Published: January 2024

The Conjunction zaś: A Contribution to the Description of the Lexicalisation of Syntactic Structures (Phrases) in Polish
The article presents hypothetical mechanisms of semantic changes that led to the transformation of the Proto-Slavic prepositional phrase *za + sę into a temporal adverb and then into a particle and a coordinating adversative conjunction, resulting in the emergence of the homonymous lexeme zaś (I, II, III). As analysed in the study, a crucial role was performed by a cognitive metaphor that grounds the space occupied by a person experiencing directed motion (cognitive subject – front : back relationship) in the temporal domain (future : past). The phrase under discussion gradually lost its original deictic features (the pronoun *sę spatially identifies the cognitive subject, e.g. spojrzał za siebie ‘he looked behind himself’ vs spojrzał przed siebie ‘he looked ahead’), gained anaphoric properties, and became semantically specialised in the Polish language (it came to express contrast to what has been mentioned earlier). Except for dialects, its grammatical polyfunctionality became limited. It is also increasingly replaced by the lexeme znów/znowu.
Spójnik zaś – przyczynek do opisu leksykalizacji struktur (wyrażeń) składniowych w polszczyźnie
Autor przedstawia hipotetyczne mechanizmy zmian semantycznych, które doprowadziły do przekształcenia psł. frazy przyimkowej *za + sę w przysłówek temporalny, a potem w partykułę i spójnik parataktyczny przeciwstawny i w rezultacie do powstania homonimicznego leksemu zaś (I, II, III). W jego rozważaniach kluczowe znaczenie ma metafora kognitywna, osadzająca przestrzeń zajmowaną przez człowieka doświadczającego ukierunkowanego ruchu (podmiot poznawczy – relacja przód : tył) w domenie temporalnej (przyszłość : przeszłość). Omawiana fraza traci z czasem pierwotne cechy deiktyczne (zaimek *sę identyfikuje przestrzennie podmiot kognitywny, por. spojrzał za siebie vs spojrzał przed siebie), zyskuje własności anaforyczne i specjalizuje się znaczeniowo w polszczyźnie (konfrontacja z tym, o czym była mowa wcześniej). Poza gwarami ogranicza też swoją polifunkcyjność gramatyczną. Coraz częściej bywa zastępowana przez leksem znów/znowu.
Digitalisation and political parties in Europe
Authors: González-Cacheda Bruno , Cancela Outeda Celso
Published: January 2024

In this article we have attempted to improve our understanding of the influence of various factors, such as the level of organizational resources, age, ideology and values, on the digitalization of political parties oriented towards participation and resource mobilization. To do this, we use version four of the Political Party Database Round (PPDB) (2022), which covers 187 parties in 26 European countries. We focus on 10 of the largest party families. The data and variables have been analyzed using various descriptive and inferential statistics. The results indicate an important level of similarity between political parties in the adoption of digital instruments. The level of resources, age and ideology, and values associated with the different party families present important explanatory and predictive limitations. We consider that the indicated results may be a consequence of a process of institutional isomoformism.
Report on an open dataset to constrain the Balmuccia peridotite body (Ivrea-Verbano Zone, Italy) through a participative gravity-modelling challenge
Authors: Hetényi György , Baron Ludovic , Scarponi Matteo , Subedi Shiba , Michailos Konstantinos , Dal Fergus , Gerle Anna , Petri Benoît , Zwahlen Jodok , Langone Antonio , Greenwood Andrew , Ziberna Luca , Pistone Mattia , Zanetti Alberto , Müntener Othmar
Published: January 2024

The Balmuccia peridotite exposes relatively fresh mantle rocks at the Earth’s surface, and as such it is of interest for geologists and geophysicists. The outcrop is a kilometre-scale feature, yet its extent at depth is insufficiently imaged. Our aim is to provide new constraints on the shape of the density anomaly this body represents, through 3D gravity modelling. In an effort to avoid personal or methodology bias, we hereby launch an invitation and call for participative modelling. We openly provide all the necessary input data: pre-processed gravity data, geological map, in situ rock densities, and digital elevation model. The expected inversion results will be compared and jointly analysed with all participants. This approach should allow us to conclude on the shape of the Balmuccia peridotite body and the associated uncertainty. This crowd effort will contribute to the site surveys preparing a scientific borehole in the area in frame of project DIVE.
Bioflocculation of pollutants in wastewater using flocculant derived from Providencia huaxiensis OR794369.1
Authors: Selepe Tlou Nelson , Maliehe Tsolanku Sidney
Published: January 2024

Background

Water pollution has become a major environmental and health concern due to increasing population and industrialisation. Microbial flocculants are promising agents for treatment of contaminated water owing to their effectiveness, eco-friendliness, and high biosafety levels. In this study, culture conditions of Providencia huaxiensis OR794369.1 were optimised and its bioflocculant was extracted, characterised and used to treat wastewater.

Results

The maximum flocculating activity of 92% and yield of 3.5 g/L were obtained when cultivation conditions were: 3% inoculum size, starch, casein, initial pH of 6, cultivation temperature of 30 oC and 72 h of fermentation. The bioflocculant is an amorphous glycoprotein biomolecule with 37.5% carbohydrates, 27.9% protein, and 34.6% uronic acids. It is composed of hydroxyl, amino, alkanes, carboxylic acid and amines groups as its main functional structures. It was found to be safe to use as it demonstrated non-cytotoxic effects on bovine dermis and African green monkey kidney cells, illustrating median inhibitory concentration (IC50) values of 180 and > 500 µg/mL on both cell lines, respectively. It demonstrated the removal efficiencies of 90% on chemical oxygen demand (COD), 97% on biological oxygen demand (BOD) and 72% on Sulphur on coal mine wastewater. It also revealed the reduction efficacies of 98% (COD) and 92% (BOD) and 70% on Sulphur on domestic wastewater.

Conclusion

The bioflocculant was effective in reducing pollutants and thus, illustrated potential to be used in wastewater treatment process as an alternative.