bluuebunny/crossref_metadata_2025 huggingface dataset:
JAC4 Alleviates Rotenone-Induced Parkinson’s Disease through the Inactivation of the NLRP3 Signal Pathway
Authors: Zou Lu , Che Zhen , Ding Kun , Zhang Chao , Liu Xia , Wang Luman , Li Aiping , Zhou Jianwei
Published: May 2023

Parkinson’s disease (PD) is the fastest-growing neurodegeneration disease, characterized typically by a progressive loss of dopaminergic neurons in the substantia nigra, and there are no effective therapeutic agents to cure PD. Rotenone (Rot) is a common and widely used pesticide which can directly inhibit mitochondrial complex I, leading to a loss of dopaminergic neurons. Our previous studies proved that the JWA gene (arl6ip5) may play a prominent role in resisting aging, oxidative stress and inflammation, and JWA knockout in astrocytes increases the susceptibility of mice to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD. JWA-activating compound 4 (JAC4) is a small-molecule activator of the JWA gene, but its role in and mechanism against PD have not yet been clarified. In the present study, we showed that the JWA expression level is strongly related to tyrosine hydroxylase (TH) in different growth periods of mice. Additionally, we constructed models with Rot in vivo and in vitro to observe the neuroprotective effects of JAC4. Our results demonstrated that JAC4 prophylactic intervention improved motor dysfunction and dopaminergic neuron loss in mice. Mechanistically, JAC4 reduced oxidative stress damage by reversing mitochondrial complex I damage, reducing nuclear factor kappa-B (NF-κB) translocation and repressing nucleotide-binding domain, leucine-rich-containing family and pyrin domain-containing-3 (NLRP3) inflammasome activation. Overall, our results provide proof that JAC4 could serve as a novel effective agent for PD prevention.
A Polyacrylonitrile Shutdown Film for Prevention of Thermal Runaway in Lithium-Ion Cells
Authors: Allen Jonathan Peter Charles , Mierzwa Marcin , Kramer Denis , Garcia-Araez Nuria , Hector Andrew L.
Published: May 2023

The electrodeposition of a polymer (polyacrylonitrile, PAN) is used to reduce the risk of thermal runaway in lithium-ion batteries, which is the most important cause of battery accidents and fires. PAN was electrodeposited on a graphite battery electrode, using cyclic voltammetry or chronoamperometry, in a solution with acrylonitrile as the solvent. The electrodeposited PAN film was characterised by Raman spectroscopy, microscopy, energy dispersive X-ray analysis, and thermogravimetric analysis, and it was found that the film thickness could be controlled by the amount of charge passed in the electrochemical experiments. The PAN-coated graphite battery electrode was then tested in lithium half-cells, obtaining capacities close to the uncoated graphite sample (ca. 360 mA h g−1) for thin (<10 µm) polymer coatings at 25 °C. Interestingly, for thicker polymer coatings (>20 µm) it was found that the capacity decreased drastically as the temperature increased beyond 80 °C. Such suppression in capacity has applications for thermal runaway protection since the electrochemical reactions of degradation of the electrolyte in contact with the electrode are the root cause of the thermal runaway process. Further work should look into alternative polymer and liquid electrolyte formulations to achieve the desired suppression of electrochemical capacity at high temperatures while retaining high capacities at the operational temperature range.
Valorisation of Biomass Waste for Sustainable Bioenergy and Biofuel Production
Authors: Sun Pei-Ti , Peng Huadong
Published: May 2023

Although the rapid development of industrialisation has brought great benefits to our societies, waste accumulation and energy depletion have inevitably grown to be critical issues in recent decades [...]
Multifunctional Biosensing Platform Based on Nickel-Modified Laser-Induced Graphene
Authors: Tong Yao , Zhang Yingying , Bao Benkun , Hu Xuhui , Li Jiuqiang , Wu Han , Yang Kerong , Zhang Senhao , Yang Hongbo , Guo Kai
Published: May 2023

Nickel plating electrolytes prepared by using a simple salt solution can achieve nickel plating on laser-induced graphene (LIG) electrodes, which greatly enhances the electrical conductivity, electrochemical properties, wear resistance, and corrosion resistance of LIG. This makes the LIG–Ni electrodes well suited for electrophysiological, strain, and electrochemical sensing applications. The investigation of the mechanical properties of the LIG–Ni sensor and the monitoring of pulse, respiration, and swallowing confirmed that the sensor can sense insignificant deformations to relatively large conformal strains of skin. Modulation of the nickel-plating process of LIG–Ni, followed by chemical modification, may allow for the introduction of glucose redox catalyst Ni2Fe(CN)6 with interestingly strong catalytic effects, which gives LIG–Ni impressive glucose-sensing properties. Additionally, the chemical modification of LIG–Ni for pH and Na+ monitoring also confirmed its strong electrochemical monitoring potential, which demonstrates application prospects in the development of multiple electrochemical sensors for sweat parameters. A more uniform LIG–Ni multi-physiological sensor preparation process provides a prerequisite for the construction of an integrated multi-physiological sensor system. The sensor was validated to have continuous monitoring performance, and its preparation process is expected to form a system for non-invasive physiological parameter signal monitoring, thus contributing to motion monitoring, disease prevention, and disease diagnosis.
Histology and Ultrastructure of the Nephron and Kidney Interstitial Cells in the Atlantic Salmon (Salmo salar Linnaeus 1758) at Different Stages of Life Cycle
Authors: Flerova Ekaterina A. , Yurchenko Victoria V. , Morozov Alexey A. , Evdokimov Evgeniy G. , Bogdanova Alena A. , Alekseev Maksim Yu. , Sendek Dmitry S. , Titov Sergey F.
Published: May 2023

This article presents data on the mesonephros histology and ultrastructure in the Atlantic salmon from the Baltic Sea and Barents Sea populations, with an emphasis on comparisons between the following ontogenetic stages: parr, smolting, adult life at sea, the adults’ return to their natal river to spawn, and spawning. The ultrastructural changes in the renal corpuscle and cells of the proximal tubules of the nephron occurred as early as the smolting stage. Such changes reflect fundamental alterations during the pre-adaptation to life in saltwater. In the Barents Sea population, the adult salmon sampled in the sea had the smallest diameters of the renal corpuscle and proximal and distal tubules, the most narrow urinary space, and the thickest basement membrane. In the group of salmon that entered the mouth of the river and spent less than 24 h in freshwater, the structural rearrangements occurred only in the distal tubules. Better development of the smooth endoplasmic reticulum and a greater abundance of mitochondria in the tubule cells were observed in the adult salmon from the Barents Sea compared to those from the Baltic Sea. Cell-immunity activation was initiated during the parr–smolt transformation. Another pronounced innate-immunity response was registered in the adults returning to the river to spawn.
The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling
Authors: Mukherjee Sandip , Chakraborty Molee , Haubner Jake , Ernst Glen , DePasquale Michael , Carpenter Danielle , Barrow James C. , Chakraborty Anutosh
Published: May 2023

Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed. We previously discovered that the inositol pyrophosphate biosynthetic enzyme IP6K1 is a target in diet-induced obesity (DIO), insulin resistance, and NAFLD. Moreover, high-throughput screening (HTS) assays and structure−activity relationship (SAR) studies identified LI-2242 as a potent IP6K inhibitor compound. Here, we tested the efficacy of LI-2242 in DIO WT C57/BL6J mice. LI-2242 (20 mg/kg/BW daily, i.p.) reduced body weight in DIO mice by specifically reducing the accumulation of body fat. It also improved glycemic parameters and reduced hyperinsulinemia. LI-2242-treated mice displayed reduced the weight of various adipose tissue depots and an increased expression of metabolism- and mitochondrial-energy-oxidation-inducing genes in these tissues. LI-2242 also ameliorated hepatic steatosis by reducing the expression of genes that enhance lipid uptake, lipid stabilization, and lipogenesis. Furthermore, LI-2242 enhances the mitochondrial oxygen consumption rate (OCR) and insulin signaling in adipocytes and hepatocytes in vitro. In conclusion, the pharmacologic inhibition of the inositol pyrophosphate pathway by LI-2242 has therapeutic potential in obesity and NAFLD.
Orchestration of Mitochondrial Function and Remodeling by Post-Translational Modifications Provide Insight into Mechanisms of Viral Infection
Authors: Park Ji Woo , Tyl Matthew D. , Cristea Ileana M.
Published: May 2023

The regulation of mitochondria structure and function is at the core of numerous viral infections. Acting in support of the host or of virus replication, mitochondria regulation facilitates control of energy metabolism, apoptosis, and immune signaling. Accumulating studies have pointed to post-translational modification (PTM) of mitochondrial proteins as a critical component of such regulatory mechanisms. Mitochondrial PTMs have been implicated in the pathology of several diseases and emerging evidence is starting to highlight essential roles in the context of viral infections. Here, we provide an overview of the growing arsenal of PTMs decorating mitochondrial proteins and their possible contribution to the infection-induced modulation of bioenergetics, apoptosis, and immune responses. We further consider links between PTM changes and mitochondrial structure remodeling, as well as the enzymatic and non-enzymatic mechanisms underlying mitochondrial PTM regulation. Finally, we highlight some of the methods, including mass spectrometry-based analyses, available for the identification, prioritization, and mechanistic interrogation of PTMs.
Circulating microRNAs for Early Diagnosis of Ovarian Cancer: A Systematic Review and Meta-Analysis
Authors: Frisk Nanna Lond Skov , Sørensen Anja Elaine , Pedersen Ole Birger Vesterager , Dalgaard Louise Torp
Published: May 2023

In this study, we conducted a systematic review and meta-analysis to summarize and evaluate the global research potential of different circulating miRNAs as an early diagnostic biomarker for OC. A systematic literature search for relevant studies was conducted in June 2020 and followed up in November 2021. The search was conducted in English databases (PubMed, ScienceDirect). The primary search resulted in a total of 1887 articles, which were screened according to the prior established inclusion and exclusion criteria. We identified 44 relevant studies, of which 22 were eligible for the quantitative meta-analysis. Statistical analysis was performed using the Meta-package in Rstudio. Standardized mean differences (SMD) of relative levels between control subjects and OC patients were used to evaluate the differential expression. All studies were quality evaluated using a Newcastle–Ottawa Scale. Based on the meta-analysis, nine miRNAs were identified as dysregulated in OC patients compared to controls. Nine were upregulated in OC patients compared to controls (miR-21, -125, -141, -145, -205, -328, -200a, -200b, -200c). Furthermore, miR-26, -93, -106 and -200a were analyzed, but did not present an overall significant difference between OC patients and controls. These observations should be considered when performing future studies of circulating miRNAs in relation to OC: sufficient size of clinical cohorts, development of consensus guidelines for circulating miRNA measurements, and coverage of previously reported miRNAs.
Influence of Chronic Fatigue Syndrome Codiagnosis on the Relationship between Perceived and Objective Psychoneuro-Immunoendocrine Disorders in Women with Fibromyalgia
Authors: Otero Eduardo , Gálvez Isabel , Ortega Eduardo , Hinchado María Dolores
Published: May 2023

Although the predominant symptom in fibromyalgia (FM) is muscle pain, and fatigue in chronic fatigue syndrome (CFS), differential diagnosis is very difficult. This research investigates the psychoneuroimmunoendocrine disorders of FM patients and ascertains whether a previous CFS diagnosis affected them. Through accelerometry objective parameters, physical activity/sedentarism levels in relation to fatigue are studied, as well as whether perceived levels of stress, anxiety, and pain correspond to objective biomarkers, all of these with respect to a reference group (RG) of women without FM. FM patients have a worse psychological state and perceived quality of life than those with RG. These perceived outcomes are consistent with impaired objective levels of a sedentary lifestyle, higher systemic levels of cortisol and noradrenaline, and lower levels of serotonin. However, FM patients with a previous CFS diagnosis had lower systemic levels of IL-8, cortisol, oxytocin, and higher levels of adrenaline and serotonin than FM patients without diagnosed CFS. In conclusion, while perceived health parameters do not detect differences, when objective neuroimmunoendocrine parameters related to stress, inflammation, pain, and fatigue are used, people with CFS could be overdiagnosed with FM. This reinforces the need for objective biomarker assessment of these patients for better diagnostic discrimination between both syndromes.
Synthesis and Characterization of PCL-Idebenone Nanoparticles for Potential Nose-to-Brain Delivery
Authors: Boyuklieva Radka , Hristozova Asya , Pilicheva Bissera
Published: May 2023

The present work is focused on the preparation of an optimal model of poly-ε-caprolactone nanoparticles as potential carriers for nasal administration of idebenone. A solvent/evaporation technique was used for nanoparticle preparation. Poly-ε-caprolactone with different molecular weights (14,000 and 80,000 g/mol) was used. Polysorbate 20 and Poloxamer 407, alone and in combination, were used as emulsifiers at different concentrations to obtain a stable formulation. The nanoparticles were characterized using dynamic light scattering, SEM, TEM, and FTIR. The resulting structures were spherical in shape and their size distribution depended on the type of emulsifier. The average particle size ranged from 188 to 628 nm. The effect of molecular weight and type of emulsifier was established. Optimal models of appropriate size for nasal administration were selected for inclusion of idebenone. Three models of idebenone-loaded nanoparticles were developed and the effect of molecular weight on the encapsulation efficiency was investigated. Increased encapsulation efficiency was found when poly-ε-caprolactone with lower molecular weight was used. The molecular weight also affected the drug release from the nanostructures. Dissolution study data were fitted into various kinetic models and the Korsmeyer–Peppas model was found to be indicative of the release mechanism of idebenone.
Evaluating the Adipose Tissue Depth as a Predictor Factor for Gestational Diabetes in Later Pregnancy—A Systematic Review
Authors: Salmen Bianca-Margareta , Pietrosel Valeria-Anca , Durdu Cristiana-Elena , Salmen Teodor , Diaconu Cosmina Theodora , Bica Ioana-Cristina , Potcovaru Claudia Gabriela , Gherghiceanu Florentina , Stoica Roxana-Adriana , Pantea Stoian Anca
Published: May 2023

The increasing prevalence of gestational diabetes mellitus (GDM) requires non-invasive and precise techniques for evaluating the predisposing risk factors such as visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). According to PRISMA, we developed a systematic review and searched after “visceral adipose tissue AND gestational diabetes” and identified 221 articles on the MEDLINE and Word of Science databases. After assessing them for inclusion criteria and two researchers screened them, 11 relevant articles were included. Although evidence is conflicting, more studies favor using US-determined VAT in GDM prediction. VAT may be more valuable than body mass index or SAT in predicting GDM. VAT can represent an additive factor to the prediction tool of the risk of developing GDM when used in conjunction with other anthropometric or biological parameters or maternal risk factors. US measurements are heterogeneous given different evaluation techniques, cut-off values and inter-operator variation. A significant limitation is the lack of a gold standard to identify GDM confidently. Pregnant women may benefit from early monitoring and preventive care if classified as high risk for GDM early in the gestational period. US-measured VAT during the first trimester of pregnancy seems a valuable and inexpensive screening approach to predict GDM development later in pregnancy, either by itself or if used in conjunction with other clinical and biological parameters.
Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson’s Patients: Neuroinflammation and Pyroptosis
Authors: Meng Hao , Wei Jia-Hang , Yu Peng-Zheng , Ren Jia-Xin , Tang Meng-Yao , Sun Jun-Yi , Yan Xiao-Yu , Su Jing
Published: May 2023

Parkinson’s disease is a severe neurodegenerative disorder. Currently, deep brain electrical stimulation (DBS) is the first line of surgical treatment. However, serious neurological impairments such as speech disorders, disturbances of consciousness, and depression after surgery limit the efficacy of treatment. In this review, we summarize the recent experimental and clinical studies that have explored the possible causes of neurological deficits after DBS. Furthermore, we tried to identify clues from oxidative stress and pathological changes in patients that could lead to the activation of microglia and astrocytes in DBS surgical injury. Notably, reliable evidence supports the idea that neuroinflammation is caused by microglia and astrocytes, which may contribute to caspase-1 pathway-mediated neuronal pyroptosis. Finally, existing drugs and treatments may partially ameliorate the loss of neurological function in patients following DBS surgery by exerting neuroprotective effects.
Perceived Connection to Instructor and Instructor Passion as Predictors of Transformative Experiences in Science
Authors: Pugh Kevin J. , Bergstrom Cassendra M. , Phillips Michael M. , Sexton Julie M. , Olson Colton , Riggs Eric M.
Published: May 2023

Transformative experience represents a deep-engagement construct and refers to experiences in which students use science content to see and experience the world in meaningful new ways outside the classroom. Such experiences are associated with deep learning (e.g., transfer) and engagement (e.g., academic and career choice) outcomes. However, research on individual factors predictive of transformative experience is limited. The current study investigated university geoscience students’ perceptions of a connection to their instructor(s) and perceptions of their instructors’ passion for the content as predictors of transformative experience. Controlling for students’ initial interest and self-efficacy in the domain, we found both these factors to be predictive of transformative experience. These results suggest science teachers may be able to support engagement in transformative experiences by connecting with students and expressing a passion for the content.
Preservice Elementary Teachers Conceptions and Self-Efficacy for Integrated STEM
Authors: Menon Deepika , Shorman Deef A. A. , Cox Derek , Thomas Amanda
Published: May 2023

Educational reform efforts have emphasized preparing highly competent and confident preservice teachers to deliver effective K-12 Science, Technology, Engineering, and Mathematics (STEM) instruction. Self-efficacy is a key variable that influences motivation and performance, and therefore it is necessary to support the development of preservice teachers’ integrated STEM teaching self-efficacy. This mixed-methods study investigates how preservice elementary teachers’ integrated STEM teaching self-efficacy is shaped during their participation in a newly redesigned STEM semester consisting of three concurrent methods courses (science and engineering, mathematics, and technology methods courses). The quantitative data sources included the Self-efficacy for Teaching Integrated STEM instrument administered as a pre- and post-test, demographic, and open-ended questionnaire. The qualitative data sources included STEM identity letters, integrated STEM models, and STEM growth reflections. Quantitative results showed statistically significant positive gains in integrated STEM-teaching self-efficacy from the beginning to the end of the semester. The results from the content analysis also revealed positive shifts in PSTs’ conceptions and attitudes about STEM. Notably, having a similar discourse across the three parallel-running methods courses provided a suitable context for preservice teachers to develop a shared understanding of integrated STEM. Implications for preservice STEM teacher preparation and research are discussed.
A Scenario-Generic Neural Machine Translation Data Augmentation Method
Authors: Liu Xiner , He Jianshu , Liu Mingzhe , Yin Zhengtong , Yin Lirong , Zheng Wenfeng
Published: May 2023

Amid the rapid advancement of neural machine translation, the challenge of data sparsity has been a major obstacle. To address this issue, this study proposes a general data augmentation technique for various scenarios. It examines the predicament of parallel corpora diversity and high quality in both rich- and low-resource settings, and integrates the low-frequency word substitution method and reverse translation approach for complementary benefits. Additionally, this method improves the pseudo-parallel corpus generated by the reverse translation method by substituting low-frequency words and includes a grammar error correction module to reduce grammatical errors in low-resource scenarios. The experimental data are partitioned into rich- and low-resource scenarios at a 10:1 ratio. It verifies the necessity of grammatical error correction for pseudo-corpus in low-resource scenarios. Models and methods are chosen from the backbone network and related literature for comparative experiments. The experimental findings demonstrate that the data augmentation approach proposed in this study is suitable for both rich- and low-resource scenarios and is effective in enhancing the training corpus to improve the performance of translation tasks.
Sensing and Secure NOMA-Assisted mMTC Wireless Networks
Authors: Chaudhary Urvashi , Ali Mohammad Furqan , Rajkumar Samikkannu , Jayakody Dushantha Nalin K.
Published: May 2023

Throughout this study, a novel network model for massive machine-type communications (mMTC) is proposed using a compressive sensing (CS) algorithm and a non-orthogonal multiple access (NOMA) scheme. Further, physical-layer security (PLS) is applied in this network to provide secure communication. We first assume that all the legitimate nodes operate in full-duplex mode; then, an artificial noise (AN) signal is emitted while receiving the signal from the head node to confuse eavesdroppers (Eve). A convex optimization tool is used to detect the active number of nodes in the proposed network using a sparsity-aware maximum a posteriori (S-MAP) detection algorithm. The sensing-aided secrecy sum rate of the proposed network is analyzed and compared with the sum rate of the network without sensing, and the closed-form expression of the secrecy outage probability of the proposed mMTC network is derived. Finally, our numerical results demonstrate the impact of an active sensing algorithm in the proposed mMTC network; improvement in the secrecy outage of the proposed network is achieved through increasing the distance of the Eve node.
Visual Extraction of Refined Operation Mode of New Power System Based on IPSO-Kmeans
Authors: Guo Xiaoli , Shan Qingyu , Zhang Zhenming , Qu Zhaoyang
Published: May 2023

Due to the influence of the high proportion of renewable energy penetration, the time-varying and complex operation mode of the new power system is gradually increasing, leading to a lack of fineness and practicality of traditional operation modes. To this end, a new visual extraction method for fine operation mode of power system is proposed. Specifically, aiming at the dimensional problem between high-dimensional electrical characteristic variables, a power grid operation data preprocessing method based on maximum absolute standardization (MaxAbs) is designed. Then, in order to reduce the impact of redundant features on the accuracy of the operation mode extraction results, the Pearson correlation coefficient is introduced to optimize the feature space relationship matrix, constructing a screening model of operating mode characteristic variables based on pearson kernel principal component analysis (P_KPCA). Then, with the clustering elbow index as the constraint condition, a K-means algorithm based on improved particle swarm optimization (IPSO-Kmeans) was proposed to realize fine operation mode extraction. Finally, the experimental analysis is carried out with the actual operation data of the power grid for one year and based on uniform manifold approximation and projection (UMAP) to visualize the extraction results of the operation mode. The validity and accuracy of the proposed method are verified.
Biotechnological Features of a Functional Non-Dairy Mixed Juice Fermented with Lacticaseibacillus paracasei SP5
Authors: Mantzourani Ioanna , Nikolaou Anastasios , Kourkoutas Yiannis , Alexopoulos Athanasios , Plessas Stavros
Published: May 2023

In the present study, a wild-type Lacticaseibacillus paracasei SP5 (L. paracasei SP5) potential probiotic strain (previously isolated from kefir grains) was applied for the 1-day fermentation of an apple–orange–carrot mixed juice. After the fermentation, the mixed juice was refrigerated in cold storage at 4 °C, and the microbiological stability, characterization of volatiles, physicochemical properties (pH, total titratable acidity (TTA), residual sugar content and organic acids content), the sensorial validation (aroma, taste and overall acceptability) of the juice, and the viability of the potential probiotic strain were analyzed. The stored juice exhibited zero colonies of yeasts/fungi and simultaneously the viability of L. paracasei SP5 was retained to 8.28 Log CFU/mL, even after the 4th week of cold storage. The pH values ranged from 3.80 to 3.35 and the TTA values ranged from 0.1344% to 0.1844% lactic acid for the unfermented juice up until the 4th week of cold storage. Furthermore, the organic acids content consisted mostly of lactic acid (4.6 to 9.1 g/L), while malic acid (3.7 to 1.5 g/L), acetic acid (0.6 g/L) and propionic acid (0.3 g/L) were detected only after the 4th week of cold storage. Residual sugar content ranged from the initial value of 122.2 g/L and 106.6 g/L at the end of cold storage. As far as the volatiles’ characterization is concerned: 9 esters, 2 organic acids, 12 alcohols, 3 aldehydes, 1 ketone, 6 terpenes and 4 sesquiterpenes (37 in total) were detected in the unfermented mixed juice and 33 compounds in the fermented juice after 4 weeks of cold storage. The sensorial properties (aroma, taste and overall acceptability) of the fermented mixed juice samples were positively influenced. Consequently, L. paracasei SP5 potential probiotic strain may be applied for the production of probiotic mixed juices, with satisfying viability, volatile profile and organoleptic results.
Experimental and Numerical Behavior of Encased Pultruded GFRP Beams under Elevated and Ambient Temperatures
Authors: Mahmood Enas M. , Ibrahim Teghreed H. , Allawi Abbas A. , El-Zohairy Ayman
Published: May 2023

In this research, experimental and numerical studies were carried out to investigate the performance of encased glass-fiber-reinforced polymer (GFRP) beams under fire. The test specimens were divided into two peer groups to be tested under the effect of ambient and elevated temperatures. The first group was statically tested to investigate the monotonic behavior of the specimens. The second group was exposed to fire loading first and then statically tested to explore the residual behavior of the burned specimens. Adding shear connectors and web stiffeners to the GFRP beam was the main parameter in this investigation. Moreover, service loads were applied to the tested beams during the fire. Utilizing shear connectors, web stiffeners, and both enhanced the load-carrying capacities of the encased beams by 100.6%, 97.3%, and 130.8%, respectively. Comparisons between the burned and unburned peer beams were presented with losses in the load-carrying capacity of the burned beams. These losses were the highest in the cases of shear connectors and web stiffeners due to the obtained severe damage, which led to more reductions in the residual behavior of the burned beams. Numerical analyses were performed using the general-purpose finite element (FE) ABAQUS package to conduct a parametric study. The investigated parameters included the effect of the exposure duration and the temperature level. The results of the FE analysis showed good agreement with the experimental results. Additional reductions in the residual capacities of the fire-damaged beams were observed due to exposure to longer fire durations. The improvements in the beam capacities due to using shear connectors and web stiffeners relative to the reference beams under the same exposure time decreased as the exposure duration increased. Furthermore, increasing the temperature to 700 °C, 800 °C, 900 °C, and 950 °C caused reductions in the residual capacities by about 25%, 45%, 70%, and 80%, respectively, for the encased beams in comparison to their peers at ambient temperature.
Processing and Preservation of Aquatic Products
Authors: Yin Tao , Shi Liu
Published: May 2023

Aquatic products represent an important food source; they include products such as fish, shrimp, shellfish, crab, and seaweed, and provide high-quality proteins, fatty acids, minerals, and other nutritional elements [...]
Formation, Structural Characterization, and Functional Properties of Corn Starch/Zeaxanthin Composites
Authors: Li Songnan , Feng Duo , Li Enpeng , Gilbert Robert G.
Published: May 2023

Zeaxanthin is a natural xanthophyll carotenoid and the main macular pigment that protects the macula from light-initiated oxidative damage, but it has poor stability and low bioavailability. Absorption of this active ingredient into starch granules as a carrier can be used to improve both zeaxanthin stability and controlled release. Optimization using three variables judged important for optimizing the system (reaction temperature of 65 °C, starch concentration of 6%, and reaction time of 2 h) was conducted for incorporation of zeaxanthin into corn starch granules, aiming for high zeaxanthin content (2.47 mg/g) and high encapsulation efficiency (74%). Polarized-light microscopy, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that the process partially gelatinized corn starch; additionally, it showed the presence of corn starch/zeaxanthin composites, with the zeaxanthin successfully trapped in corn starch granules. The half-life time of zeaxanthin in corn starch/zeaxanthin composites increased to 43 days as compared with that of zeaxanthin alone (13 days). The composites show a rapid increase in zeaxanthin release with in vitro intestinal digestion, which is favorable for possible use in living systems. These findings could have application in designing effective starch-based carriers of this bioactive ingredient with enhanced storage stability and improved intestines-targeted controlled-release delivery.
The Nutrients and Volatile Compounds in Stropharia rugoso-annulata by Three Drying Treatments
Authors: Jiang Yu , Zhao Qilong , Deng Haolan , Li Yongjun , Gong Di , Huang Xiaodan , Long Danfeng , Zhang Ying
Published: May 2023

This study aimed to examine the differences in the nutrients and volatile compounds of Stropharia rugoso-annulata after undergoing three different drying treatments. The fresh mushrooms were dried using hot air drying (HAD), vacuum freeze drying (VFD), and natural air drying (NAD), respectively. After that, the nutrients, volatile components, and sensory evaluation of the treated mushrooms were comparably analyzed. Nutrients analysis included proximate compositions, free amino acids, fatty acids, mineral elements, bioactive compositions, and antioxidant activity. Volatile components were identified by headspace-solid phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) and analyzed with principal component analysis (PCA). Finally, sensory evaluation was conducted by ten volunteers for five sensory properties. The results showed that the HAD group had the highest vitamin D2 content (4.00 μg/g) and antioxidant activity. Compared with other treatments, the VFD group had higher overall nutrient contents, as well as being more preferred by consumers. Additionally, there were 79 volatile compounds identified by HS-SPME-GC-MS, while the NAD group showed the highest contents of volatile compounds (1931.75 μg/g) and volatile flavor compounds (1307.21 μg/g). PCA analysis suggested the volatile flavor compositions were different among the three groups. In summary, it is recommended that one uses VFD for obtaining higher overall nutritional values, while NAD treatment increased the production of volatile flavor components of the mushroom.
Experimental Study on Enhanced Oil Recovery of PPG/ASP Heterogeneous System after Polymer Flooding
Authors: Pi Yanfu , Su Zailai , Cao Ruibo , Li Bo , Liu Jinxin , Fan Xinyu , Zhao Mingjia
Published: May 2023

Following the application of polymer flooding in Daqing Oilfield, the heterogeneity between different layers has intensified, resulting in the formation of more favorable seepage channels and cross-flow of displacement fluids. Consequently, the circulation efficiency has decreased, necessitating the exploration of methods to enhance oil recovery. This paper focuses on experimental research utilizing a newly developed precrosslinked particle gel (PPG) combined with alkali surfactant polymer (ASP) to create a heterogeneous composite system. This study aims to improve the efficiency of heterogeneous system flooding after polymer flooding. The addition of PPG particles enhances the viscoelasticity of the ASP system, reduces the interfacial tension between the heterogeneous system and crude oil, and provides excellent stability. The heterogeneous system has high resistance and residual resistance coefficients during the migration process in a long core model, achieving an improvement rate of up to 90.1% under the permeability ratio of 9 between high and low permeability layers. Employing heterogeneous system flooding after polymer flooding can increase oil recovery by 14.6%. Furthermore, the oil recovery rate of low permeability layers can reach 28.6%. The experimental results confirm that the application of PPG/ASP heterogeneous flooding after polymer flooding can effectively plug high-flow seepage channels and improve oil washing efficiency. These findings hold significant implications for further reservoir development after polymer flooding.
The Sensitivity of Micro—Macro Mechanical Behaviour of Sand to the Inter-Particle Properties
Authors: Momeni Ali , Eshiet Kenneth Imo-Imo Israel , Sheng Yong
Published: May 2023

Sand is a particulate material but is treated as a continuum solid in some engineering analyses. This approach is proven to be acceptable when dealing with geotechnical structures, provided an adequate factor of safety is applied so that there is no risk of failure. However, the continuum approach does not account for the effect of interparticle forces on the micro–macro behaviour of sand. Sand could be modelled as a particulate material using the discrete element method (DEM), taking into account its discrete nature. This paper shows how the microscopic contact properties between the idealised sand particles influence the macro-mechanical behaviour, highlighting the development of the fabric as the soil approaches failure. Thirty DEM biaxial tests were performed to study the sensitivity of the macro–micro mechanical properties of sand to the inter-particle properties of an idealised sand particle. The conditions of these simulations were the same (e.g., particle size distribution, number of particles, porosity after radius enlargement, boundary conditions, and rate of loading). The sensitivity of the pre-peak, peak, and post-peak behaviour of these simulations to the inter-particle properties of an idealised sand particle was studied. Two extra DEM biaxial tests under different confining pressures were performed to verify the cohesionless nature of the synthetic material used for this study. Since a two-dimensional DEM is used for this study, a detailed approach to interpret the results assuming either a plane strain or a plane stress situation was discussed. This study highlighted the critical inter-particle properties and the range over which these influence macro-mechanical behaviour. The results show that Young’s modulus is mainly dependent on the normal contact stiffness, and peak stress and the angle of internal friction are greatly dependent on the inter-particle coefficient of friction, while Poisson’s ratio and volumetric behaviour of particulate sand are dictated mainly by shear contact stiffness. A set of relationships were established between inter-particle properties and macro-machinal parameters such as Young’s modulus, Poisson’s ratio, and angle of internal friction. The elastoplastic parameters obtained from these tests are qualitatively in agreement with the typical medium and dense sand behaviour.
Barriers and Facilitators of Communication in the Medication Reconciliation Process during Hospital Discharge: Primary Healthcare Professionals’ Perspectives
Authors: Rojas-Ocaña María Jesús , Teresa-Morales Cristina , Ramos-Pichardo Juan Diego , Araujo-Hernández Miriam
Published: May 2023

The WHO established that medication errors are the most common and preventable errors and represent an expenditure of 42 billion U.S. dollars annually. The risk of medication errors increases in transitions between levels of care, mainly from hospital care to primary healthcare after hospital discharge. In this context, communication is a key element in the safety of the medication reconciliation process. The aim of this paper was to describe the barriers to, and facilitators of, effective communication during the medication reconciliation process at hospital discharge in people over 65 years of age, from the perspective of primary healthcare professionals. A qualitative descriptive study was designed, and in-depth interviews were conducted with 21 individuals, of whom 13 were nurses and 8 were physicians. This study was carried out with healthcare professionals belonging to primary healthcare centres in Huelva (Spain). Following content analysis of the discourses we identified 19 categories, grouped into three areas: interlevel communication, communication between primary healthcare professionals, and communication between healthcare professionals and patients/caregivers. The barriers found mainly relate to the adequacy and use of technological tools, time available, workload and the level of collaboration of patients/caregivers. Facilitating elements for communication in medication reconciliation included technologies, such as computerized medical history, protocolization of clinical sessions, the presence of case management nurse and interdisciplinary teamwork.
Effects of Exercise Intervention (with and without Joint Mobilization) in Patients with Adhesive Capsulitis: A Systematic Review and Meta-Analysis
Authors: Lee Jong Hyeon , Jeon Hyung Gyu , Yoon Yong Jin
Published: May 2023

This review aimed to investigate the effects of exercise and exercise with joint mobilization on shoulder range of motion (ROM) and subjective symptom recovery in patients with adhesive capsulitis (AC). Related Studies published from 2000 to 2021 that were peer-reviewed and for which pre-and post-values could be calculated were extracted from PubMed, CINAHL, SPORTDiscus, and Web of Science. Nine studies met our inclusion criteria. As a result of calculating the standard mean difference (SMD) and 95% confidence intervals (CI), both exercise and exercise with joint mobilization showed a large effect on shoulder ROM and subjective outcomes. The combination showed a more significant effect than exercise alone on shoulder flexion (SMD = −1.59 [−2.34, −0.65]), extension (SMD = −1.47 [−2.05, −0.89]), internal rotation (SMD = −1.77 [−2.17, −1.36], external rotation (SMD = −2.18 [−2.92, −1.44]), and abduction ROM (SMD = −1.99 [CI −3.86, −0.12]). Patients who performed exercise alone showed a higher effect of improvement in subjective function (SMD = 3.15 [2.06, 4.24]) and pain (SMD = 4.13 [1.86, 6.41]). Based on these results, an AC rehabilitation exercise program should be developed by adjusting the amount of exercise and joint mobilization by identifying the patient’s needs, subjective symptoms, and ROM.
The Influence of Nitrogen and Phosphorus Addition on Growth of the Invasive C4 Grass Saccharum spontaneum
Authors: Cummings Justin A. , Parker Ingrid M. , Gilbert Gregory S.
Published: May 2023

Invasive C4 grasses can inhibit the natural regeneration of secondary forest in tropical landscapes after the cessation of intensive use for grazing and agriculture. In Panama, invasive Saccharum spontaneum forms dense stands that require active management to re-establish forest successional processes. In this region, restoration strategies typically involve clearing grass cover manually and applying fertilizer prior to planting tree seedlings. However, if fertilizers alleviate nutrient limitation and enhance grass competition with tree seedlings, these practices may exacerbate the costs of Saccharum control and hamper restoration goals. Here, we evaluated how S. spontaneum responds to nitrogen and phosphorus addition in the field to determine whether S. spontaneum is nutrient limited in this system. S. spontaneum was limited by both nitrogen and phosphorus, as revealed through increased foliar nutrient concentrations. S. spontaneum biomass was significantly greater in both nitrogen and phosphorus addition plots after both the first growth period (early rainy season) and second growth period (late rainy season), with stronger effects of nutrient limitation during the second growth period for both N limitation and N and P co-limitation. Nutrient limitation in S. spontaneum highlights a potential risk of fertilizer applications during restoration, agriculture, and agroforestry activities in which invasion of this aggressive weed is a challenge to land management.
Transformation of Indonesian Health System: The Impact on Medical Education
Authors: Octavius Gilbert Sterling , Wijayanto Rhendy , Yanto Theo Audi
Published: May 2023

Indonesia is currently revamping its medical sector—a process dubbed medical transformation. In place of this transformation, medical education has also received spotlights due to the number of medical universities and the lack of medical specialists in Indonesia. Therefore, several plans will revolutionize Indonesian medical education and its health system. This commentary will briefly comment on those transformations and their potential impact in the near and distant future.
DFT Analysis of the Electronic and Structural Properties of Lanthanide Nitride Cluster Fullerenes Ln3N@C80
Authors: Martínez-Flores César , Basiuk Vladimir A.
Published: May 2023

We have undertaken a DFT study of the nitride cluster fullerenes (NCFs) Ln3N@C80 for the complete series of fourteen lanthanides plus lanthanum by using the PBE functional with the Grimme’s dispersion correction (PBE-D2). We tested the DN and DND basis sets, which are equivalent to 6-31G and 6-31G(d) Pople-type basis sets, respectively. Due to the known convergence problems when treating lanthanide-containing systems, only with the DN basis set was it possible to complete the calculations (geometry optimization and analysis of selected electronic parameters) for all the fifteen NCFs. We found that the bending of the Ln3N cluster increases as the ionic radius increases, in general agreement with the available X-ray diffraction data. The Ln3N cluster becomes more planar as the Ln–N bond length is contracted, and the C80 cavity slightly deforms. The HOMO-LUMO energies and distribution, as well as the charge and spin of the encapsulated metal ions, are analyzed.
A Biopsychosocial Evaluation of Post-Acute Outcome of Patients with Severe Brain Lesions Recovering from Coma: An Exploratory Study
Authors: La Framboise Noah F. , Rochat Etienne , Diserens Karin
Published: May 2023

Currently, very little is known about the holistic outcome of patients recovering from coma. The aim of this retrospective exploratory study was to evaluate the outcomes of patients recovering from coma after care in an acute neurorehabilitation unit with particular focus on their biopsychosocial and spiritual needs in the post-acute phase of recovery. We included 12 patients and evaluated clinical outcome evolution by comparing standard neurobehavioral scores from patient files measured in the acute and post-acute phases. We assessed patient needs using the Quality of Life after Brain Injury scale (QOLIBRI) and classified self-reported complaints mentioned in patient files according to the International Classification of Functioning, Disability and Health framework (ICF). Mean patient evolution was a Level of Cognitive Functioning Scale (LCF)-r increase of 3.33 levels (range = 2); a Disability Rating Scale score (DRS) of −3.27 points (SD = 3.78); a Functional Ambulation Classification (FAC) scale score of 1.83 (range = 5); and a Glasgow Outcome Scale (GOS) median = 0 (Interquartile range = 1). Main patient complaints concerned mental functioning (n = 7), sensory functioning and pain (n = 6), neuromusculoskeletal and movement problems (n = 5), and major life areas (n = 5). To conclude, a significant handicap that affects their daily life was present in the post-acute phase in most patients. Complaints involved biopsychosocial and spiritual elements. The neurobehavioral scale results do not necessarily correlate with the subjective representations patients had of their condition.
Mobile Solutions for Clinical Surveillance and Evaluation in Infancy—General Movement Apps
Authors: Marschik Peter B. , Kwong Amanda K. L. , Silva Nelson , Olsen Joy E. , Schulte-Rüther Martin , Bölte Sven , Örtqvist Maria , Eeles Abbey , Poustka Luise , Einspieler Christa , Nielsen-Saines Karin , Zhang Dajie , Spittle Alicia J.
Published: May 2023

The Prechtl General Movements Assessment (GMA) has become a clinician and researcher toolbox for evaluating neurodevelopment in early infancy. Given that it involves the observation of infant movements from video recordings, utilising smartphone applications to obtain these recordings seems like the natural progression for the field. In this review, we look back on the development of apps for acquiring general movement videos, describe the application and research studies of available apps, and discuss future directions of mobile solutions and their usability in research and clinical practice. We emphasise the importance of understanding the background that has led to these developments while introducing new technologies, including the barriers and facilitators along the pathway. The GMApp and Baby Moves apps were the first ones developed to increase accessibility of the GMA, with two further apps, NeuroMotion and InMotion, designed since. The Baby Moves app has been applied most frequently. For the mobile future of GMA, we advocate collaboration to boost the field’s progression and to reduce research waste. We propose future collaborative solutions, including standardisation of cross-site data collection, adaptation to local context and privacy laws, employment of user feedback, and sustainable IT structures enabling continuous software updating.