bluuebunny/crossref_metadata_2025 huggingface dataset:
Drought vulnerability and risk assessments: state of the art, persistent gaps, and research agenda
Authors: Hagenlocher Michael , Meza Isabel , Anderson Carl C , Min Annika , Renaud Fabrice G , Walz Yvonne , Siebert Stefan , Sebesvari Zita
Published: May 2019

Reducing the social, environmental, and economic impacts of droughts and identifying pathways towards drought resilient societies remains a global priority. A common understanding of the drivers of drought risk and ways in which drought impacts materialize is crucial for improved assessments and for the identification and (spatial) planning of targeted drought risk reduction and adaptation options. Over the past two decades, we have witnessed an increase in drought risk assessments across spatial and temporal scales drawing on a multitude of conceptual foundations and methodological approaches. Recognizing the diversity of approaches in science and practice as well as the associated opportunities and challenges, we present the outcomes of a systematic literature review of the state of the art of people-centered drought vulnerability and risk conceptualization and assessments, and identify persisting gaps. Our analysis shows that, of the reviewed assessments, (i) more than 60% do not explicitly specify the type of drought hazard that is addressed, (ii) 42% do not provide a clear definition of drought risk, (iii) 62% apply static, index-based approaches, (iv) 57% of the indicator-based assessments do not specify their weighting methods, (v) only 11% conduct any form of validation, (vi) only ten percent develop future scenarios of drought risk, and (vii) only about 40% of the assessments establish a direct link to drought risk reduction or adaptation strategies, i.e. consider solutions. We discuss the challenges associated with these findings for both assessment and identification of drought risk reduction measures, and identify research needs to inform future research and policy agendas in order to advance the understanding of drought risk and support pathways towards more drought resilient societies.
The structures underpinning vulnerability: examining landscape-society interactions in a smallholder coffee agroforestry system
Authors: Morel Alexandra C , Hirons Mark , Demissie Sheleme , Gonfa Techane , Mehrabi Zia , Long Peter R , Rifai Sami , Woldemariam Gole Tadesse , Mason John , McDermott Constance L , Boyd Emily , Robinson Elizabeth J Z , Malhi Yadvinder , Norris Ken
Published: May 2019

Smallholder farmers dependent on rain-fed agriculture are particularly vulnerable to extreme climate events and, therefore, it is necessary to identify adaptive measures that would increase farmer resilience to these shocks. The management options in a low-input system, like forest coffee (Coffea arabica), are limited and there are several factors out of farmers’ control driving their vulnerability to changing climatic conditions. These can relate to social structures and landscape factors, which can interact to reduce farmers’ adaptive capacity, creating a state of contextual vulnerability. We explored the potential synergies of this interaction across elevation, patch area and shade management gradients for smallholder coffee farms around the UNESCO Yayu Coffee Forest Biosphere Reserve in Ethiopia before, during and immediately following the 2015/16 El Niño. We documented a dramatic collapse in coffee yields across all farms, resulting in coffee incomes 29.5% ± 18.0% and 19.5% ± 10.0% of 2014 incomes in 2015 and 2016, respectively. We identified farms at elevations between 1500 and 1600 m with canopy openness between 40% and 45% as being consistently low yielding over our study period. We found these farmers had the highest rates of income diversification and, therefore, were already exhibiting adaptive capacity. Farmers with the largest income losses were spatially concentrated between 1600 and 1700 m, located in larger patch areas with lower canopy openness. Farmers at this elevation have access to poor infrastructure, restrictions on shade management and reported higher dependence on income from coffee, indicating an interaction of biotic and social factors exacerbating their vulnerability. Unfortunately, due to a nationally declared state of emergency, we were unable to survey farmers on the adaptive measures they undertook; therefore, we are limited in assessing their resilience. However, we do show the importance of considering both biotically and socially-mediated influences for assessing smallholder vulnerability, particularly barriers to diversifying incomes.
Berezinskii–Kosterlitz–Thouless transition on regular and Villain types of q-state clock models
Authors: Surungan Tasrief , Masuda Shunsuke , Komura Yukihiro , Okabe Yutaka
Published: May 2019

We study q-state clock models of regular and Villain types with

using cluster-spin updates and observed double transitions in each model. We calculate the correlation ratio and size-dependent correlation length as quantities for characterizing the existence of Berezinskii–Kosterlitz–Thouless (BKT) phase and its transitions by large-scale Monte Carlo simulations. We discuss the advantage of correlation ratio in comparison to other commonly used quantities in probing BKT transition. Using finite size scaling of BKT type transition, we estimate transition temperatures and corresponding exponents

. The comparison between the results from both types revealed that the existing transitions belong to BKT universality.
Roadmap on all-optical processing
Authors: Minzioni Paolo , Lacava Cosimo , Tanabe Takasumi , Dong Jianji , Hu Xiaoyong , Csaba Gyorgy , Porod Wolfgang , Singh Ghanshyam , Willner Alan E , Almaiman Ahmed , Torres-Company Victor , Schröder Jochen , Peacock Anna C , Strain Michael J , Parmigiani Francesca , Contestabile Giampiero , Marpaung David , Liu Zhixin , Bowers John E , Chang Lin , Fabbri Simon , Ramos Vázquez María , Bharadwaj Vibhav , Eaton Shane M , Lodahl Peter , Zhang Xiang , Eggleton Benjamin J , Munro William John , Nemoto Kae , Morin Olivier , Laurat Julien , Nunn Joshua
Published: May 2019

The ability to process optical signals without passing into the electrical domain has always attracted the attention of the research community. Processing photons by photons unfolds new scenarios, in principle allowing for unseen signal processing and computing capabilities. Optical computation can be seen as a large scientific field in which researchers operate, trying to find solutions to their specific needs by different approaches; although the challenges can be substantially different, they are typically addressed using knowledge and technological platforms that are shared across the whole field. This significant know-how can also benefit other scientific communities, providing lateral solutions to their problems, as well as leading to novel applications. The aim of this Roadmap is to provide a broad view of the state-of-the-art in this lively scientific research field and to discuss the advances required to tackle emerging challenges, thanks to contributions authored by experts affiliated to both academic institutions and high-tech industries. The Roadmap is organized so as to put side by side contributions on different aspects of optical processing, aiming to enhance the cross-contamination of ideas between scientists working in three different fields of photonics: optical gates and logical units, high bit-rate signal processing and optical quantum computing. The ultimate intent of this paper is to provide guidance for young scientists as well as providing research-funding institutions and stake holders with a comprehensive overview of perspectives and opportunities offered by this research field.
Effect of Arteriovenous Fistula Creation on Systolic and Diastolic Blood Pressure in Patients With Pre-dialysis Advanced Chronic Kidney Disease
Authors: Mathew Roy O , Fleg Jerome , Rangaswami Janani , Cai Bo , Asif Arif , Sidhu Mandeep S , Bangalore Sripal
Published: May 2019

BACKGROUND

Central arteriovenous fistula (cAVF) has been investigated as a therapeutic measure for treatment-resistant hypertension in patients without advanced chronic kidney disease (CKD). There is considerable experience with the use of AVF for hemodialysis in patients with end-stage renal disease (ESRD). However, there is sparse data on the blood pressure (BP) effects of an AVF among patients with ESRD. We hypothesized that AVF creation would significantly reduce BP compared with patients who did not have an AVF among patients with ESRD before starting hemodialysis.

METHODS

BPs were compared during the 12 months before hemodialysis initiation in 399 patients with an AVF or AV graft created and 4,696 patients without either.

RESULTS

After propensity score matching 1:2 ratio (AVF to no AVF), repeated measures analysis of variance revealed significant reductions of –1.7 mm Hg systolic and –3.9 mm Hg diastolic BP 12 months in patients after AVF creation; P = 0.025 and P < 0.001, respectively, compared with those with no AVF.

CONCLUSIONS

These findings suggest that AVF creation results in modest BP reduction in patients with pre-dialysis ESRD who require AVF for eventual hemodialysis therapy. Preferential diastolic BP reduction suggests that greater work is needed to characterize the ideal patient subset in which to use cAVF for treatment-resistant hypertension in those without advanced CKD.
Role of ploidy in colonization of alpine habitats in natural populations of Arabidopsis arenosa
Authors: Wos Guillaume , Mořkovská Jana , Bohutínská Magdalena , Šrámková Gabriela , Knotek Adam , Lučanová Magdalena , Španiel Stanislav , Marhold Karol , Kolář Filip
Published: May 2019

Background and Aims

Polyploidy is an important driver of plant diversification and adaptation to novel environments. As a consequence of genome doubling, polyploids often exhibit greater colonizing ability or occupy a wider ecological niche than diploids. Although elevation has been traditionally considered as a key driver structuring ploidy variation, we do not know if environmental and phenotypic differentiation among ploidy cytotypes varies along an elevational gradient. Here, we tested for the consequences of genome duplication on genetic diversity, phenotypic variation and habitat preferences on closely related diploid and tetraploid populations that coexist along approx. 2300 m of varying elevation.

Methods

We sampled and phenotyped 45 natural diploid and tetraploid populations of Arabidopsis arenosa in one mountain range in Central Europe (Western Carpathians) and recorded abiotic and biotic variables at each collection site. We inferred genetic variation, population structure and demographic history in a sub-set of 29 populations genotyped for approx. 36 000 single nucleotide polymorphisms.

Key Results

We found minor effects of polyploidy on colonization of alpine stands and low genetic differentiation between the two cytotypes, mirroring recent divergence of the polyploids from the local diploid lineage and repeated reticulation events among the cytotypes. This pattern was corroborated by the absence of ecological niche differentiation between the two cytotypes and overall phenotypic similarity at a given elevation.

Conclusions

The case of A. arenosa contrasts with previous studies that frequently showed clear niche differentiation between cytotypes. Our work stresses the importance of considering genetic structure and past demographic processes when interpreting the patterns of ploidy distributions, especially in species that underwent recent polyploidization events.
Systematic Review and Meta-analysis of Treatment Interruptions in Human Immunodeficiency Virus (HIV) Type 1–infected Patients Receiving Antiretroviral Therapy: Implications for Future HIV Cure Trials
Authors: Stecher Melanie , Claßen Annika , Klein Florian , Lehmann Clara , Gruell Henning , Platten Martin , Wyen Christoph , Behrens Georg , Fätkenheuer Gerd , Vehreschild Jörg Janne
Published: May 2019

Background

Safety and tolerability of analytical treatment interruptions (ATIs) as a vital part of human immunodeficiency virus type 1 (HIV-1) cure studies are discussed. We analyzed current evidence for the occurrence of adverse events (AEs) during TIs.

Methods

Our analysis included studies that reported on AEs in HIV-1–infected patients undergoing TIs. All interventional and observational studies were reviewed, and results were extracted based on predefined criteria. The proportion of AEs was pooled using random-effects models. Metaregression was used to explore the influence of baseline CD4+ T-cell count, viral load, study type, previous time on combined antiretroviral therapy, and follow-up interval during TIs.

Results

We identified 1048 studies, of which 22 studies including 7104 individuals fulfilled the defined selection criteria. Included studies had sample sizes between 6 and 5472 participants, with durations of TI cycles ranging from 7 days to 27 months. The intervals of HIV-1-RNA testing varied from 2 days to 3 months during TIs. The overall proportion of AEs during TIs >4 weeks was 3% (95% confidence interval [CI], 0%–7%) and was lower in studies with follow-up intervals ≤14 days (0%; 95% CI, 0%–1%) than in studies with wider follow-up intervals (6%; 95% CI, 2%–13%; P value for interaction = .01).

Conclusions

We found moderate-quality evidence indicating that studies with narrow follow-up intervals did not show a substantial increase in AEs during TIs. Our findings indicate that ATI may be a safe strategy as part of HIV-1 cure trials by closely monitoring for HIV-1 rebound.
Nesting season, nest age, and disturbance, but not habitat characteristics, affect nest survival of Chinese grouse
Authors: Zhao Jin-Ming , Yang Chen , Lou Ying-Qiang , Shi Mei , Fang Yun , Sun Yue-Hua
Published: May 2019

Nest survival is a vital component of breeding success, and affects population dynamics, as the loss of nests is the main cause of reproductive failure in birds. To identify key factors for the conservation of Chinese grouse Tetrastes sewerzowi, we tested the effects of nest concealment, nest age, nesting season, and habitat edge on nest daily survival rate (DSR) of Chinese grouse using 54 nests found at Lianhuashan Nature Reserve, Gansu, China, 2009–2012. Moreover, we controlled for the effect of research activity by testing the effect of nest checks on DSR. Overall, mammal predation caused 93% of nest failures. DSR was 0.986 ± 0.0038 in the constant model and the probability of a nest with a full clutch of 6 eggs surviving the entire 40-day nesting period was 0.526 ± 0.090. DSR decreased with nest age and nesting season (from 19 May to 3 July). Mammals instead of avian predators being responsible for most nest failures suggest that nest sites might be selected to avoid visual avian predators, but not olfactory mammalian predators, and the decreasing trend of DSR with nest age and nesting season could attribute to an additive exposure effect. Moreover, nest checks conducted by investigators significantly lowered nest DSR, especially during the late period of nesting season and for older nests. Mammalian predators might locate the nest site by following the investigator’s odor. Based on our results, we suggest that the late incubation stage is a particularly vulnerable period for nest survival of Chinese grouse and those researchers should adjust their activities around nests to balance the need of acquiring accurate data and decreasing nest predation risk.
What is the Source of Bilingual Cross-Language Activation in Deaf Bilinguals?
Authors: Morford Jill P , Occhino Corrine , Zirnstein Megan , Kroll Judith F , Wilkinson Erin , Piñar Pilar
Published: May 2019

When deaf bilinguals are asked to make semantic similarity judgments of two written words, their responses are influenced by the sublexical relationship of the signed language translations of the target words. This study investigated whether the observed effects of American Sign Language (ASL) activation on English print depend on (a) an overlap in syllabic structure of the signed translations or (b) on initialization, an effect of contact between ASL and English that has resulted in a direct representation of English orthographic features in ASL sublexical form. Results demonstrate that neither of these conditions is required or enhances effects of cross-language activation. The experimental outcomes indicate that deaf bilinguals discover the optimal mapping between their two languages in a manner that is not constrained by privileged sublexical associations.
Reduction of Plant Suitability for Corn Leaf Aphid (Hemiptera: Aphididae) Under Elevated Carbon Dioxide Condition
Authors: Chen Yu , Serteyn Laurent , Wang Zhenying , He KangLai , Francis Frederic
Published: May 2019

In the current context of global climate change, atmospheric carbon dioxide (CO2) concentrations are continuously rising with potential influence on plant–herbivore interactions. The effect of elevated CO2 (eCO2) on feeding behavior of corn leaf aphid, Rhopalosiphum maidis (Fitch) on barley seedlings Hordeum vulgare L. was tracked using electrical penetration graph (EPG). The nutrient content of host plant and the developmental indexes of aphids under eCO2 and ambient CO2 (aCO2) conditions were also investigated. Barley seedlings under eCO2 concentration had lower contents of crude protein and amino acids. EPG analysis showed the plants cultivated under eCO2 influenced the aphid feeding behavior, by prolonging the total pre-probation time of the aphids (wandering and locating the feeding site) and the ingestion of passive phloem sap. Moreover, fresh body weight, fecundity and intrinsic population growth rate of R. maidis was significantly decreased in eCO2 in contrast to aCO2 condition. Our findings suggested that changes in plant nutrition caused by eCO2, mediated via the herbivore host could affect insect feeding behavior and population dynamics.
Asymmetric Consumption Effects of Transitory Income Shocks*
Authors: Christelis Dimitris , Georgarakos Dimitris , Jappelli Tullio , Pistaferri Luigi , van Rooij Maarten
Published: May 2019

We use the responses of a representative sample of Dutch households to survey questions that ask how much their consumption would change in response to unexpected, transitory income shocks (positive or negative). The questionnaire also distinguishes between relatively small income changes (a one-month increase or drop in income), and relatively larger ones (equal to three-months' income). The results are broadly in line with models of intertemporal choice with precautionary saving, borrowing constraints and finite horizons.
Chlamydia muridarum infection induces CD4+ T cells apoptosis via PI3K/AKT signal pathway
Authors: Zheng Ningbo , Sun Lida , Pang Gaoju , Zha Xiaoyu , Niu Wenhao , Tan Lu , Zhang Hong , Bai Hong
Published: May 2019

Apoptosis is essential for the homeostatic control of the lymphocytes number during the development of an immune response to an invasive microorganism. CD4+ T cells play a major role in homeostasis of the immune system and are sufficient to confer protection against Chlamydia muridarum (Cm) infection in mice. The present study demonstrated that phosphatidylinositol 3-kinase (PI3K) p110δ mRNA and phosphorylation of protein kinase B (p-AKT) level were significantly increased in lung cells and spleen cells at day 3 and day 7 post-infection, p-AKT level was inhibited when adding PI3K inhibitor LY294002. Moreover, Cm infection induced high levels of IL-2/IL-2Rα in CD4+ T cells, which may relate to PI3K/AKT signal pathway activation. We observed that Cm infection significantly induced apoptosis of CD4+ T cells. The related apoptosis proteins Bcl-2 and Mcl-1 uneven expression levels were induced in CD4+ T cells by Cm infection. These findings provided in vivo and in vitro evidence that Cm infection induces CD4+ T cells apoptosis possibly via PI3K/AKT signal pathway.
Change Over Time in Caregiving Networks for Older Adults With and Without Dementia
Authors: Spillman Brenda C , Freedman Vicki A , Kasper Judith D , Wolff Jennifer L
Published: May 2019

Objectives

We provide national estimates of caregiving networks for older adults with and without dementia and examine how these networks develop over time. Most prior research has focused on primary caregivers and rarely on change over time.

Method

We identify a cohort of older adults continuously followed in the National Health and Aging Trends Study between 2011 and 2015 and receiving help from family members or unpaid caregivers in 2015 (n = 1,288). We examine differences by dementia status in network size, types of assistance and task sharing, and composition—differentiating between “specialist” and “generalist” caregivers helping in one versus multiple activity domains. Multinomial regression is used to estimate change over time in network task sharing and composition.

Results

In 2015, older adults with dementia had larger caregiving networks involving more task sharing than those without dementia and more often relied on generalist caregivers, especially the subset assisting with medical, household, and mobility or self-care activities. Uniformly greater reliance over time on these more intensely engaged generalist caregivers chiefly accounts for larger dementia networks.

Discussion

Findings lend support to the need for caregiver training on managing multiple task domains and—for dementia caregivers in particular—task-sharing skills. More generally, the design of new approaches to better support older adults and their caregivers should consider the complexity, heterogeneity, and change over time in caregiving networks.
Magnetic mineral assemblage as a potential indicator of depositional environment in gas-bearing Silurian shales from Northern Poland
Authors: Niezabitowska D K , Szaniawski R , Jackson M
Published: May 2019

Organic matter preservation and associated conditions during deposition, important in the context of fossil fuel exploration, are commonly determined by advanced geochemical analyses. However, the relation between organic matter preservation and magnetic mineral composition remains poorly constrained. The aim of the studies was to check the potential of magnetic mineral differentiation between facies containing various amounts of organic matter as a factor to better understand the processes which influence water chemistry at the bottom of sedimentary basins, and thus to better understand factors controlling the preservation of organic matter. To determine the composition and the properties of magnetic minerals, detailed low-temperature measurements of Saturation Isothermal Remanent Magnetization and hysteresis loops were performed on two types of rocks, Silurian shales from the Baltic Basin (northern Poland). The analysed shale facies are characterized by similar thermal evolution, but different amounts of organic matter: the Pelplin Formation, containing a modest content of organic matter, in which we also examined early diagenetic carbon concretions; and the Jantar Formation, which represents an organic-rich ‘sweet spot’ layer. In both facies, the results indicate the presence of multi- or pseudo-single domain magnetite, which is interpreted as detrital in origin. However, the main observation gained from this study is the relation between magnetic mineral assemblage in the studied shales and the amount of organic matter: in the rocks with modest amounts of organic matter we observed hematite, while in organic-rich layers hematite was absent. Hematite (mostly single-domain grains) preserved in the Pelplin Formation suggests that stable oxygen-rich conditions were present at the bottom of the sedimentary basin continuously during deposition, concretion cementation and compaction. In turn, its absence in the Jantar Formation suggests that during sedimentation and early diagenesis more anoxic conditions appeared. Generally, findings show that the presence of hematite is related to the significantly lower amount of organic matter in sedimentary rocks. Thus, presence of this mineral may be a useful indicator of organic matter preservation.
Lenders’ selection capabilities, patent quality, and the outcome of patent-backed loans
Authors: Caviggioli Federico , Scellato Giuseppe , Ughetto Elisa
Published: May 2019

In this paper, we investigate the phenomenon of patent collateralization by empirically focusing on the factors that affect the outcome of the collateralization process. In particular, we want to examine to what extent patent quality, lenders’ characteristics, as well as lenders’ selection capabilities (i.e. in identifying high-quality patents) affect the likelihood of observing a security interest release. We identify the patents recorded in security agreements and their release from the USPTO Patent Assignment database. The final dataset is made up of a total of 8818 security interest agreement records, involving 133,110 patents pledged as collateral for debt between 2007 and 2010. We find evidence that a security interest is more likely to be released for patents with a higher technical merit and when the lenders are more experienced and are specialty finance companies. When considering other types of lenders (i.e. banks in particular) or less experienced lenders, the positive association between the security interest release and the technical merit of the pledged patent is lower. The evidence suggests that IP-backed loans represent an effective financial channel for those firms that control valuable intangible assets and that experience and specialization allow lenders to develop better selection capabilities.
How Unavoidable Are Analytical Treatment Interruptions in HIV Cure–Related Studies?
Authors: Margolis David M , Deeks Steven G
Published: May 2019

In this discussion, 2 established researchers and clinical trialists debate their opposing views on the utility, benefits, and risks of the use of analytical interruption of antiretroviral therapy as a clinical trial end point and outcome measure in human studies seeking to induce remission of or eradicate human immunodeficiency virus infection.
Split Vision: Multidimensionality in the European Union's Legal Policy Space
Authors: Larsson Olof , Naurin Daniel
Published: May 2019

The European Union (EU) offers an example of deep judicialization, where highly salient political values are adjudicated on a regular basis. In such contexts, political attention may shift from national sovereignty costs (the vertical dimension) to distributive conflicts within and between states (the horizontal dimension), creating a multidimensional legal policy space. We discuss the implications of this setting for judicial behavior and argue that it may create both opportunities and pitfalls for international judges, depending on how the dimensions are related. If the institutional interests of judges in promoting international law systematically favor some states over others on the horizontal dimension, judicial activism is likely to provoke feedback effects in the form of severe legitimacy problems. If the dimensions are unrelated, on the other hand, adjudicators become further empowered. We draw on a large dataset to show how the Court of Justice of the EU has been able to use divisions between states on the left-right dimension to enhance the legitimacy and autonomy of European law.
Mortality dynamics of Pseudomonas aeruginosa bloodstream infections and the influence of defective OprD on mortality: prospective observational study
Authors: Yoon Eun-Jeong , Kim Dokyun , Lee Hyukmin , Lee Hye Sun , Shin Jeong Hwan , Park Yoon Soo , Kim Young Ah , Shin Jong Hee , Shin Kyeong Seob , Uh Young , Jeong Seok Hoon
Published: May 2019

Background

To assess the mortality dynamics of patients with Pseudomonas aeruginosa bloodstream infections (BSIs) and the influence of OprD deficiencies of the microorganism on early mortality.

Methods

A prospective multicentre observational study was conducted with 120 patients with P. aeruginosa BSIs occurring between May 2016 and April 2017 in six general hospitals in South Korea. PCR and sequencing were carried out to identify the alterations in oprD and the presence of virulence factors. Cox regression was used to estimate the risk factors for mortality at each timepoint and Kaplan–Meier survival analyses were performed to determine the mortality dynamics.

Results

During the 6 week follow-up, 10.8% (13/120) of the patients with P. aeruginosa BSIs died in 2 weeks, 14.2% (17/120) in 4 weeks and 20.0% (24/120) in 6 weeks, revealing a steep decrease in cumulative survival between the fourth and sixth weeks. ICU admission and SOFA score were risk factors for mortality in any weeks after BSI onset and causative OprD-defective P. aeruginosa had a risk tendency for mortality within 6 weeks. Among the 120 P. aeruginosa blood isolates, 14 were XDR, nine produced either IMP-6 or VIM-2 MBL, and 21 had OprD deficiency.

Conclusions

BSIs caused by OprD-defective P. aeruginosa resulted in a 2-fold higher 6 week mortality rate (33.3%) than that of BSIs caused by OprD-intact P. aeruginosa (17.2%), likely due to the decreased susceptibility to carbapenems and bacterial persistence in clinical settings.
Salinity tolerance in chickpea is associated with the ability to ‘exclude’ Na from leaf mesophyll cells
Authors: Kotula Lukasz , Clode Peta L , Jimenez Juan De La Cruz , Colmer Timothy D
Published: May 2019

Salinity tolerance is associated with Na ‘exclusion’ from, or ‘tissue tolerance’ in, leaves. We investigated whether two contrasting chickpea genotypes, salt-tolerant Genesis836 and salt-sensitive Rupali, differ in leaf tissue tolerance to NaCl. We used X-ray microanalysis to evaluate cellular Na, Cl, and K concentrations in various cell types within leaflets and also in secretory trichomes of the two chickpea genotypes in relation to photosynthesis in control and saline conditions. TEM was used to assess the effects of salinity on the ultrastructure of chloroplasts. Genesis836 maintained net photosynthetic rates (A) for the 21 d of salinity treatment (60 mM NaCl), whereas A in Rupali substantially decreased after 11 d. Leaflet tissue [Na] was low in Genesis836 but had increased markedly in Rupali. In Genesis836, Na was accumulated in epidermal cells but was low in mesophyll cells, whereas in Rupali cellular [Na] was high in both cell types. The excessive accumulation of Na in mesophyll cells of Rupali corresponded to structural damage to the chloroplasts. Maintenance of photosynthesis and thus salinity tolerance in Genesis836 was associated with an ability to ‘exclude’ Na from leaflets and in particular from the photosynthetically active mesophyll cells, and to compartmentalize Na in epidermal cells.
Disruption of giant molecular clouds and formation of bound star clusters under the influence of momentum stellar feedback
Authors: Li Hui , Vogelsberger Mark , Marinacci Federico , Gnedin Oleg Y
Published: May 2019

Energetic feedback from star clusters plays a pivotal role in shaping the dynamical evolution of giant molecular clouds (GMCs). To study the effects of stellar feedback on the star formation efficiency of the clouds and the dynamical response of embedded star clusters, we perform a suite of isolated GMC simulations with star formation and momentum feedback subgrid models using the moving-mesh hydrodynamics code Arepo. The properties of our simulated GMCs span a wide range of initial mass, radius, and velocity configurations. We find that the ratio of the final stellar mass to the total cloud mass, ϵint, scales strongly with the initial cloud surface density and momentum feedback strength. This correlation is explained by an analytic model that considers force balancing between gravity and momentum feedback. For all simulated GMCs, the stellar density profiles are systematically steeper than that of the gas at the epochs of the peaks of star formation, suggesting a centrally concentrated stellar distribution. We also find that star clusters are always in a sub-virial state with a virial parameter ∼0.6 prior to gas expulsion. Both the sub-virial dynamical state and steeper stellar density profiles prevent clusters from dispersal during the gas removal phase of their evolution. The final cluster bound fraction is a continuously increasing function of ϵint. GMCs with star formation efficiency smaller than 0.5 are still able to form clusters with large bound fractions.
Multiwavelength radio observations of a brightest cluster galaxy at z = 1.71: detection of a modest active galactic nucleus and evidence for extended star formation
Authors: Trudeau Ariane , Webb Tracy , Hlavacek-Larrondo Julie , Noble Allison , Gendron-Marsolais Marie-Lou , Lidman Christopher , Mezcua Mar , Muzzin Adam , Wilson Gillian , Yee H K C
Published: May 2019

We present deep, multiwavelength radio observations of SpARCS104922.6 + 564032.5, a z = 1.71 galaxy cluster with a starbursting core. Observations were made with the Karl G. Jansky Very Large Array (JVLA) in three bands: 1–2 GHz, 4–8 GHz, and 8–12 GHz. We detect a radio source coincident with the brightest cluster galaxy (BCG) that has a spectral index of α = 0.44 ± 0.29 and is indicative of emission from an active galactic nucleus. The radio luminosity is consistent with the average luminosity of the lower redshift BCG sample, but the flux densities are 6σ below the predicted values of the star-forming spectral energy distribution based on far infrared data. Our new fit fails to simultaneously describe the far infrared and radio fluxes. This, coupled with the fact that no other bright source is detected in the vicinity of the BCG implies that the star formation region, traced by the infrared emission, is extended or clumpy and not located directly within the BCG. Thus, we suggest that the star-forming core might not be driven by a single major wet merger, but rather by several smaller galaxies stripped of their gas or by a displaced cooling flow, although more data are needed to confirm any of those scenarios.
The effect of polymorphisms in the promoter of the BIRC5 gene on the risk of oesophageal squamous cell carcinoma and patient’s outcomes
Authors: Wang Na , Li Yan , Zhou Rong-Miao , Cui Sai-Jin , Cao Shi-Ru , Huang Xi , Huo Xiang-Ran , Shan Bao-En
Published: May 2019

Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) is an inhibitor of apoptosis proteins and plays a key role in apoptosis or programmed cell death. In the present study, we evaluated the effect of BIRC5 gene polymorphisms on the risk of developing oesophageal squamous cell carcinoma (ESCC) and patients’ outcomes in a high-incidence population from northern China. A population-based case-control study was performed in 597 ESCC patients and 597 control subjects.Survival data were available for 211 patients who received platinum-based chemotherapy after surgery. Five polymorphisms (-31 C>G, -241 C>T, -625 G>C, -644 T>C and -1547 A>G) in the promoter of the BIRC5 gene were genotyped by the polymerase chain reaction-ligase detection reaction (PCR-LDR) method. Compared with the -31 CC genotype, the -31 CG/GG genotype of -31 C>G single nucleotide polymorphism (SNP) was associated with a significant elevated risk of ESCC [adjusted odds ratio (OR) = 1.40, 95% confidence interval (CI) = 1.07–1.84]. Interestingly, this association was stronger among females, younger patients and non-smokers in stratified analyses (adjusted OR = 1.72, 95% CI = 1.07–2.75; adjusted OR = 1.61, 95% CI = 1.10–2.36; adjusted OR = 1.80, 95% CI = 1.26–2.58, respectively]. Survival analyses showed that the T allele of -241 C>T SNP was associated with poor prognosis [hazard ratio (HR) = 2.99, 95% CI = 1.09–8.19) and that the C allele of -625 G>C SNP was associated with good prognosis (HR = 0.62, 95% CI = 0.38–0.99) in ESCC patients. The -31 C>G polymorphism may be involved in the development of ESCC, and the -241 C>T and -625 G>C polymorphisms may be useful prognostic markers for ESCC.
RNAmod: an integrated system for the annotation of mRNA modifications
Authors: Liu Qi , Gregory Richard I
Published: May 2019

Dynamic and reversible RNA modifications such as N6-methyladenosine (m6A) can play important roles in regulating messenger RNA (mRNA) splicing, export, stability and translation. Defective mRNA modification through altered expression of the methyltransferase and/or demethylases results in developmental defects and cancer progression. Identifying modified mRNAs, annotating the distribution of modification sites across the mRNA, as well as characterizing and comparing other modification features are essential for studying the function and elucidating the mechanism of mRNA modifications. Several methods including methylated RNA immunoprecipitation and sequencing (MeRIP-seq) are available for the detection of mRNA modifications. However, a convenient and comprehensive tool to annotate diverse kinds of mRNA modifications in different species is lacking. Here, we developed RNAmod (https://bioinformatics.sc.cn/RNAmod), an interactive, one-stop, web-based platform for the automated analysis, annotation, and visualization of mRNA modifications in 21 species. RNAmod provides intuitive interfaces to show outputs including the distribution of RNA modifications, modification coverage for different gene features, functional annotation of modified mRNAs, and comparisons between different groups or specific gene sets. Furthermore, sites of known RNA modification, as well as binding site data for hundreds of RNA-binding proteins (RBPs) are integrated in RNAmod to help users compare their modification data with known modifications and to explore the relationship with the binding sites of known RBPs. RNAmod is freely available and meets the emerging need for a convenient and comprehensive analysis tool for the fast-developing RNA modification field.
Treatment Outcomes and Dose Rate Effects Following Gamma Knife Stereotactic Radiosurgery for Vestibular Schwannomas
Authors: Smith Deborah Ruth , Saadatmand Heva Jasmine , Wu Cheng-Chia , Black Paul J , Wuu Yen-Ruh , Lesser Jeraldine , Horan Maryellen , Isaacson Steven R , Wang Tony J C , Sisti Michael B
Published: May 2019

BACKGROUND

Gamma Knife radiosurgery (GKRS; Elekta AB) remains a well-established treatment modality for vestibular schwannomas. Despite highly effective tumor control, further research is needed toward optimizing long-term functional outcomes. Whereas dose-rate effects may impact post-treatment toxicities given tissue dose-response relationships, potential effects remain largely unexplored.

OBJECTIVE

To evaluate treatment outcomes and potential dose-rate effects following definitive GKRS for vestibular schwannomas.

METHODS

We retrospectively reviewed 419 patients treated at our institution between 1998 and 2015, characterizing baseline demographics, pretreatment symptoms, and GKRS parameters. The cohort was divided into 2 dose-rate groups based on the median value (2.675 Gy/min). Outcomes included clinical tumor control, radiographic progression-free survival, serviceable hearing preservation, hearing loss, and facial nerve dysfunction (FND). Prognostic factors were assessed using Cox regression.

RESULTS

The study cohort included 227 patients with available follow-up. Following GKRS 2-yr and 4-yr clinical tumor control rates were 98% (95% CI: 95.6%-100%) and 96% (95% CI: 91.4%-99.6%), respectively. Among 177 patients with available radiographic follow-up, 2-yr and 4-yr radiographic progression-free survival rates were 97% (95% CI: 94.0%-100.0%) and 88% (95% CI: 81.2%-95.0%). The serviceable hearing preservation rate was 72.2% among patients with baseline Gardner-Robertson class I/II hearing and post-treatment audiological evaluations. Most patients experienced effective relief from prior headaches (94.7%), tinnitus (83.7%), balance issues (62.7%), FND (90.0%), and trigeminal nerve dysfunction (79.2%), but not hearing loss (1.0%). Whereas GKRS provided effective tumor control independently of dose rate, GKRS patients exposed to lower dose rates experienced significantly better freedom from post-treatment hearing loss and FND (P = .044).

CONCLUSION

Whereas GKRS provides excellent tumor control and effective symptomatic relief for vestibular schwannomas, dose-rate effects may impact post-treatment functional outcomes. Further research remains warranted.
The History of Antibiotic Treatment of Osteomyelitis
Authors: Cortés-Penfield Nicolás W , Kulkarni Prathit A
Published: May 2019

Antibiotic treatment of osteomyelitis has evolved substantially over the past 80 years. Traditional teachings (eg, that antimicrobials must be given parenterally, selected based upon ratios of achieved bone vs serum drug levels, and continued for 4–6 weeks) are supported by limited data. New studies are challenging this dogma, however. In this review, we seek to contextualize the discussion by providing a narrative, chronologic review of osteomyelitis treatment spanning the pre-antibiotic era through the present day and by describing the quality of evidence supporting each component of traditional osteomyelitis therapy.
Large angular scale fluctuations of near-infrared extragalactic background light based on the IRTS observations
Authors: Kim Min Gyu , Matsumoto Toshio , Lee Hyung Mok , Jeong Woong-Seob , Tsumura Kohji , Seo Hyunjong , Tanaka Masahiro
Published: May 2019

We measure the spatial fluctuations of the Near-Infrared Extragalactic Background Light (NIREBL) from 2° to 20° in angular scale at the 1.6 and $2.2\, \mu \mathrm{m}$ using data obtained with Near-Infrared Spectrometer (NIRS) on board the Infrared Telescope in Space (IRTS). The brightness of the NIREBL is estimated by subtracting foreground components such as zodiacal light, diffuse Galactic light, and integrated star light from the observed sky. The foreground components are estimated using well-established models and archive data. The NIREBL fluctuations for the 1.6 and $2.2\, \mu \mathrm{m}$ connect well toward the sub-degree scale measurements from previous studies. Overall, the fluctuations show a wide bump with a center at around 1° and the power decreases toward larger angular scales with nearly a single power-law spectrum (i.e., ${F[\sqrt{l(l+1)C_l/2\pi }]} \sim \theta ^{-1}]$, indicating that the large-scale power is dominated by the random spatial distribution of the sources. After examining several known sources, contributors such as normal galaxies, high-redshift objects, intra-halo light, and far-IR cosmic background, we conclude that the excess fluctuation at around the 1° scale cannot be explained by any of them.
Psychophysiological insomnia and respiratory tract infections: results of an infection-diary-based cohort study
Authors: Nieters Alexandra , Blagitko-Dorfs Nadja , Peter Hans-Hartmut , Weber Susanne
Published: May 2019

Study Objectives

The immune theory of sleep suggests an important role of sleep for a functioning immune system. Insomnia has been associated with heightened risk for infections. The aim of the study was to test whether psychophysiological insomnia (PI) is associated with subsequent respiratory tract infections (RTIs) in the context of an infection-diary-based cohort study.

Methods

We recruited 674 adults from a cross-sectional survey on airway infections into the airway infection susceptibility (AWIS) cohort and invited them to self-report in diaries incident RTIs experienced during 7097 months (mean of 11.9 months of completed infection diaries per individual). The Regensburg Insomnia Scale (RIS) was assessed at baseline to measure PI. As outcome, we considered an infection diary score summing up prospectively reported RTIs.

Results

The RIS score correlated significantly with the infection diary score summarizing reported RTIs (correlation coefficient = 0.265, p < 0.001). Adjustments by putative confounders did only marginally affect this relationship. No significant differences in the relationship between RIS score and diary score were found for subgroups including those by gender, body mass index, perceived stress, and comorbidity. People affected by a combination of high PI and obesity were eight times more likely to belong to the group reporting the highest 10% of RTIs compared to the nonobese group with low RIS score (p < 0.001). A high RIS score in men was associated with a higher neutrophil-to-lymphocyte ratio, an indicator of inflammation.

Conclusions

Our data support the relevance of adequate sleep for an immune system ready to fight pathogens and prevent airway infections.
Relationship between inflammatory biomarkers and oxidative stress with uterine health in dairy cows with different dry period lengths1
Authors: Mayasari Novi , Trevisi Erminio , Ferrari Annarita , Kemp Bas , Parmentier Henk K , van Knegsel Ariette T M
Published: May 2019

Earlier studies indicated that the inflammatory status of dairy cows in early lactation could not be fully explained by the negative energy balance (NEB) at that moment. The objective of the present study was to determine relationships between inflammatory biomarkers and oxidative stress with uterine health in dairy cows after different dry period lengths. Holstein–Friesian dairy cows were assigned to one of three dry period lengths (0-, 30-, or 60-d) and one of two early lactation rations (glucogenic or lipogenic ration). Cows were fed either a glucogenic or lipogenic ration from 10-d before the expected calving date. Part of the cows which were planned for a 0-d dry period dried themselves off and were attributed to a new group (0 → 30-d dry period), which resulted in total in four dry period groups. Blood was collected (N = 110 cows) in weeks −3, −2, −1, 1, 2, and 4 relative to calving to determine biomarkers for inflammation, liver function, and oxidative stress. Uterine health status (UHS) was monitored by scoring vaginal discharge (VD) based on a 4-point scoring system (0, 1, 2, or 3) in weeks 2 and 3 after calving. Cows were classified as having a healthy uterine environment (HU, VD score = 0 or 1 in both weeks 2 and 3), nonrecovering uterine environment (NRU, VD score = 2 or 3 in week 3), or a recovering uterine environment (RU, VD score = 2 or 3 in week 2 and VD score= 0 or 1 in week 3). Independent of dry period length, cows with NRU had higher plasma haptoglobin (P = 0.05) and lower paraoxonase levels (P < 0.01) in the first 4 weeks after calving and lower liver functionality index (P < 0.01) compared with cows with HU. Cows with NRU had lower plasma albumin (P = 0.02) and creatinine (P = 0.02) compared with cows with a RU, but not compared with cows with HU. Independent of UHS, cows with a 0 → 30-d dry period had higher bilirubin levels compared with cows with 0-, 30-, or 60-d dry period (P < 0.01). Cows with RU and fed a lipogenic ration had higher levels of albumin in plasma compared with cows with NRU and fed a lipogenic ration (P < 0.01). In conclusion, uterine health was related to biomarkers for inflammation (haptoglobin and albumin) and paraoxonase in dairy cows in early lactation. Cows which were planned for a 0-d dry period, but dried themselves off (0 → 30-d dry period group) had higher bilirubin levels, which was possibly related to a more severe NEB in these cows. Inflammatory biomarkers in dairy cows in early lactation were related to uterine health in this period.
Monensin and mineral supplementation economically increase yearling cattle weight gain on California annual rangeland
Authors: Forero Larry C , Davy Josh S , McMurry Bryan E , Oltjen James W
Published: May 2019

Stocker operators generally graze cattle on California annual rangelands from November to May. The profit margins of these operators is low as cattle sell for less per unit at the end of the season when compared with the beginning. This creates a need for methods to economically increase weight gain, which can help to mitigate market volatility. The use of monensin is common in much of the United States but has not been researched in the unique winter annual rangelands of California. Likewise, research that formally documents weight gain from the correction of selenium deficiency on these rangelands is also lacking. Trials were conducted over 2 years to determine weight gain differences with treatments of salt only (control), salt with monensin, mineral supplement, and mineral supplement with monensin. All three treatments increased weight gain by 12%, 9%, and 15% over feeding straight salt, respectively. It appears that selenium deficiency correction and supplemental monensin should be considered economical weight gain improvement tools for yearling cattle grazing California annual rangeland.