bluuebunny/crossref_metadata_2025 huggingface dataset:
Torsion of a Communicating Hydrocele Presented as Acute Scrotum: A Case Report and Literature Review
Authors: Siviero Ivonete , Méio Ivens Baker , Ferrante Saulo Marcos Rebello , Forny Danielle Nunes , Cunha André Lima da
Published: November 2016

Torsion of a communicating hydrocele is extremely rare, and the cause is unclear. We report the case of a 3-year-old boy referred to us with acute scrotum. Operative findings revealed torsion of a communicating hydrocele with a 360-degree rotation of the distal end. We performed surgical excision of the necrotic cystic mass and high ligation of the peritoneal communication. A high index of suspicion is required for the correct diagnosis and treatment of this condition, which should be included among the causes of acute scrotum in childhood.
Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor
Authors: Marchlewska Katarzyna , Filipiak Eliza , Walczak-Jedrzejowska Renata , Oszukowska Elzbieta , Sobkiewicz Slawomir , Wojt Malgorzata , Chmiel Jacek , Kula Krzysztof , Slowikowska-Hilczer Jolanta
Published: November 2016

Objective. To investigate sperm DNA fragmentation and sperm functional maturity in men from infertile couples (IC) and men with testicular germ cell tumor (TGCT). Materials and Methods. Semen samples were collected from 312 IC men and 23 men with TGCT before unilateral orchiectomy and oncological treatment. The sperm chromatin dispersion test was performed to determine DNA fragmentation index (DFI) and the ability of sperm to bind with hyaluronan (HA) was assessed. Results. In comparison with the IC men, the men with TGCT had a higher percentage of sperm with fragmented DNA (median 28% versus 21%; p<0.01) and a lower percentage of HA-bound sperm (24% versus 66%; p<0.001). Normal results of both analyses were observed in 24% of IC men and 4% of men with TGCT. Negative Spearman’s correlations were found between DFI and the percentage of HA-bound sperm in the whole group and in IC subjects and those with TGCT analyzed separately. Conclusions. Approximately 76% of IC men and 96% with TGCT awaiting orchiectomy demonstrated DNA fragmentation and/or sperm immaturity. We therefore recommend sperm banking after unilateral orchiectomy, but before irradiation and chemotherapy; the use of such a deposit appears to be a better strategy to obtain functionally efficient sperms.
Endoscopic Management of the Difficult Bile Duct Stones: A Single Tertiary Center Experience
Authors: Ödemiş Bülent , Kuzu Ufuk Barış , Öztaş Erkin , Saygılı Fatih , Suna Nuretdin , Coskun Orhan , Aksoy Adem , Sırtaş Zeliha , Arı Derya , Akpınar Yener
Published: November 2016

Background. Most common bile duct (CBD) stones can be removed with standard techniques using endoscopic retrograde cholangiopancreatography (ERCP), but in some cases additional methods are needed. In this study we aimed to investigate the management of patients with difficult stones and the factors that affect the outcome of patients that have undergone periodic endobiliary stenting. Materials and Methods. Data of 1529 patients with naive papilla who had undergone ERCP with an indication of CBD stones was evaluated retrospectively. Stones that could not be removed with standard techniques were defined as “difficult stones.” Cholangiograms of patients who had difficult stones were revised prospectively. Results. Two hundred and eight patients (13.6%) had difficult stones; 150 of these patients were followed up with periodic endobiliary stenting and successful biliary clearance was achieved in 85.3% of them. Both CBD (p<0.001) and largest stone size (p<0.001) were observed to be significantly reduced between the first and the last procedure. This difference was even more significant in successfully treated patients. Conclusions. Periodic endobiliary stenting can be used as an effective treatment for patients with difficult stones. Sizes of the CBD and of the largest stone are independent risk factors that affect the success rate.
Motor Speech Apraxia in a 70-Year-Old Man with Left Dorsolateral Frontal Arachnoid Cyst: A [18F]FDG PET-CT Study
Authors: Bohnen Nicolaas I. , Haugen Jacob , Kluin Karen , Kotagal Vikas
Published: November 2016

Motor speech apraxia is a speech disorder of impaired syllable sequencing which, when seen with advancing age, is suggestive of a neurodegenerative process affecting cortical structures in the left frontal lobe. Arachnoid cysts can be associated with neurologic symptoms due to compression of underlying brain structures though indications for surgical intervention are unclear. We present the case of a 70-year-old man who presented with a two-year history of speech changes along with decreased initiation and talkativeness, shorter utterances, and dysnomia. [18F]Fluorodeoxyglucose (FDG) Positron Emission and Computed Tomography (PET-CT) and magnetic resonance imaging (MRI) showed very focal left frontal cortical hypometabolism immediately adjacent to an arachnoid cyst but no specific evidence of a neurodegenerative process.
Expression, Purification, and Characterization of a Sucrose Nonfermenting 1-Related Protein Kinases 2 of Arabidopsis thaliana in E. coli-Based Cell-Free System
Authors: Zhang Xu , Zhang Shuangxi , Wang Jun , Zi Jing , Wang Jianhui , Chen Shaolin , Wan Yi
Published: November 2016

The plant-specific sucrose nonfermenting 1-related protein kinase 2 (SnRK2) family is considered an important regulator of plant responses to abiotic stresses such as drought, cold, salinity, and nutrition deficiency. However, little information is available on how SnRK2s regulate sulfur deprivation responses in Arabidopsis. Large-scale production of SnRK2 kinases in vitro can help to elucidate the biochemical properties and physiological functions of this protein family. However, heterogenous expression of SnRK2s usually leads to inactive proteins. In this study, we expressed a recombinant Arabidopsis SnRK2.1 in a modified E. coli cell-free system, which combined two kinds of extracts allowing for a convenient and affordable protein preparation. The recombinant SnRK2.1 was produced in large-scale and the autophosphorylation activity of purified SnRK2.1 was characterized, allowing for further biochemical and substrate binding analysis in sulfur signaling. The application of this improved E. coli cell-free system provides us a promising and convenient platform to enhance expression of the target proteins economically.
The Development of Criteria for the Selection of Chinese Peer Educators in HIV Management: A Delphi Study
Authors: Qiu Yan , Shen Jiayin , Lu Hongzhou
Published: November 2016

To develop an expert consensus opinion of the criteria for selection of peer educator for HIV/AIDS care program, twenty experts were invited to complete a two-round Delphi consultation. Response rates of the panelists for the first and second rounds were both 100%, and the authority coefficient of the experts was 0.75. Experts achieved consensus on a total of nine items (75%) on completion of the study. The Precedence Chart Method was used to calculate the weight of each indicator, and then a priority list was generated accordingly. This study provides the initial selection criteria for HIV/AIDS peer educators in Shanghai as well as in China.
Corrosion Performance of Cu-Based Coins in Artificial Sweat
Authors: Porcayo-Calderon J. , Rodríguez-Díaz R. A. , Porcayo-Palafox E. , Martinez-Gomez L.
Published: November 2016

The performance of different Cu-based coins in artificial sweat was evaluated. The electrochemical behavior of the coins was determined by potentiodynamic polarization curves, linear polarization resistance, and electrochemical impedance spectroscopy. Regardless of the chemical composition of the Cu-based coins, they showed similar polarization curves; particularly, the observed similarity in the anodic zone suggests that the corrosion mechanism is the same in all cases. The presence of Ni and Zn does not appreciably affect the corrosion resistance of Cu. However, the presence of both elements affects the corrosion resistance of Cu. Electrochemical impedance spectroscopy measurements showed the presence of three time constants with very similar characteristics, again indicating that the main corrosion mechanism is the same in all cases. Equivalent circuits confirmed that the corrosion performance of the Ni-Zn-Cu coins depends on the Zn/Ni ratio, such that decreasing this value decreases the corrosion resistance of the alloy. In general, nickel has a detrimental effect due to the formation of highly soluble Ni-based corrosion products.
Interdigital Neuroma in the Second Intermetatarsal Space Associated with Metatarsophalangeal Joint Instability
Authors: Matsumoto Takumi , Chang Song Ho , Izawa Naohiro , Ohshiro Yohei , Tanaka Sakae
Published: November 2016

The entrapment theory is the most commonly accepted theory concerning the development of interdigital neuroma; it incriminates the deep transverse metatarsal ligament as the major causative factor of the condition. This report presents a patient with interdigital neuroma in the second intermetatarsal space, which was strongly suspected to be caused by the metatarsophalangeal joint instability due to plantar plate injury. Surgical intervention revealed that the neuroma was located more distally and dorsally than the deep transverse metatarsal ligament and was pinched between the adjacent metatarsal heads, suggesting the involvement of the metatarsophalangeal joint instability and chronic trauma as etiologies in this case.
Synthesis and Antiproliferative Activity of Some Quinoline and Oxadiazole Derivatives
Authors: Ahsan Mohamed Jawed , Shastri Sunil , Yadav Rita , Hassan Mohd. Zaheen , Bakht Mohammed Afroz , Jadav Surender Singh , Yasmin Sabina
Published: November 2016

In continuance of our search for newer antiproliferative agents we report herein the synthesis and antiproliferative studies of two series (5a–j and 10a–c) of heterocyclic compounds. All the new compounds were characterized by IR, NMR, and mass spectral data. The antiproliferative activity of 10 compounds (5a–j) was carried out on HeLa (cervix cancer cell line) and MDA-MB-435 (melanoma) and LC50, TGI, and GI50 were calculated, while the antiproliferative activity of 3 compounds (10a–c) was carried out against nine different panels of nearly 60 cell lines (NCI-60) according to the National Cancer Institute (NCI US) Protocol at 10 μM. 1-(7-Hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)-3-(4-methoxylphenyl)urea (5j) was found to have antiproliferative activity with GI50 of 35.1 μM against HeLa (cervix cancer cell line) and 60.4 μM against MDA-MB-435 (melanoma), respectively. The compounds 10a, 10b, and 10c showed antiproliferative activity with comparatively higher selectivity towards HOP-92 (Non-Small Cell Lung Cancer) with percent growth inhibitions (GIs) of 34.14, 35.29, and 31.59, respectively.
Couplingq-Deformed Dark Energy to Dark Matter
Authors: Dil Emre
Published: November 2016

We propose a novel coupled dark energy model which is assumed to occur as aq-deformed scalar field and investigate whether it will provide an expanding universe phase. We consider theq-deformed dark energy as coupled to dark matter inhomogeneities. We perform the phase-space analysis of the model by numerical methods and find the late-time accelerated attractor solutions. The attractor solutions imply that the coupledq-deformed dark energy model is consistent with the conventional dark energy models satisfying an acceleration phase of universe. At the end, we compare the cosmological parameters of deformed and standard dark energy models and interpret the implications.
Bradycardia Associated with Steroid Use for Laryngeal Edema in an Adult: A Case Report and Literature Review
Authors: John Preeti R. , Khaladj-Ghom Ariana , Still Kimberly L.
Published: November 2016

Steroids are used for specific indications in the perioperative period to reduce laryngeal or spinal cord edema, or for prophylaxis and treatment of postoperative nausea and vomiting. Given the other potential causes for hemodynamic alterations in the perioperative setting, it is important for physicians to be aware of cardiovascular side effects of short term steroids. Changes in blood pressure and heart rate, cardiac dysrhythmias, and even death have been described in patients receiving short term intravenous steroids. Bradycardia has been reported following short term methylprednisolone and dexamethasone therapy in both adult and pediatric patients. There are only two case reports in the literature of bradycardia following short term intravenous dexamethasone use in adult patients. This is the first case report that describes bradycardia following the use of dexamethasone in the postoperative setting for management of laryngeal edema in an adult. Telemetry and twelve lead electrocardiograms revealed sinus bradycardia and correlated directly with administration of dexamethasone in our patient. Bradycardia resolved following discontinuation of dexamethasone. We advocate for hemodynamic monitoring in patients receiving more than one dose of intravenous steroid therapy in the perioperative period, especially those with known cardiac and hepatic comorbidities and those taking medications with negative chronotropic effects.
CBT4BN: A Randomized Controlled Trial of Online Chat and Face-to-Face Group Therapy for Bulimia Nervosa
Authors: Zerwas Stephanie C. , Watson Hunna J. , Hofmeier Sara M. , Levine Michele D. , Hamer Robert M. , Crosby Ross D. , Runfola Cristin D. , Peat Christine M. , Shapiro Jennifer R. , Zimmer Benjamin , Moessner Markus , Kordy Hans , Marcus Marsha D. , Bulik Cynthia M.
Published: November 2016

Objective: Although cognitive-behavioral therapy (CBT) represents the first-line evidence-based psychotherapy for bulimia nervosa (BN), most individuals seeking treatment do not have access to this specialized intervention. We compared an Internet-based manualized version of CBT group therapy for BN conducted via a therapeutic chat group (CBT4BN) to the same treatment conducted via a traditional face-to-face group therapy (CBTF2F). Method: In a two-site, randomized, controlled noninferiority trial, we tested the hypothesis that CBT4BN would not be inferior to CBTF2F. A total of 179 adult patients with BN (2.6% males) received up to 16 sessions of group CBT over 20 weeks in either CBT4BN or CBTF2F, and outcomes were compared at the end of treatment and at the 12-month follow-up. Results: At the end of treatment, CBT4BN was inferior to CBTF2F in producing abstinence from binge eating and purging. However, by the 12-month follow-up, CBT4BN was mostly not inferior to CBTF2F. Participants in the CBT4BN condition, but not CBTF2F, continued to reduce their binge-eating and purging frequency from the end of treatment to the 12-month follow-up. Conclusions: CBT delivered online in a group chat format appears to be an efficacious treatment for BN, although the trajectory of recovery may be slower than face-to-face group therapy. Online chat groups may increase accessibility of treatment and represent a cost-effective approach to service delivery. However, barriers in service delivery such as state-specific license and ethical guidelines for online therapists need to be addressed.
Joseph-Frédéric-Benoît Charrière - How to Explain His Success as One of the Most Famous Surgical Instrument Makers Regarding His Life from Childhood to Death
Authors: Badawi Jasmin Katrin
Published: November 2016

Introduction: We use the name ‘Charrière' every day as a unit of measurement. This article explains his success as one of the most famous instrument makers who ever lived. Materials and Methods: A review of the literature was completed using PubMed. Additionally, material of historical sources like the museum of Bulle was used. Results: Joseph-Frédéric-Benoît Charrière was born in Switzerland in 1803. At the age of 13, he moved to Paris and learned the profession of a cutler. In 1820, he took over the workshop of his teacher Vincent. Dupuytren was one of the most important people in Charrière's professional life. Charrière specialized in the fabrication of surgical instruments of such high quality that he was very sought after by famous surgeons. In 1837, Charrière went to Sheffield, England, to learn more about working with metals and alloys. In 1851, he was inducted into the Legion of Honour. Charrière died in 1876 in Paris. Conclusions: The patronage of Dupuytren was a very important supporting factor in Charrière's professional life, but mainly his great courage, the willingness to learn from others, his creativity and technical fantasy and his curiosity and broad interest in a lot of different fields explain his unmatched professional success.
Stimulation of the Nonneuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes
Authors: Uberti Francesca , Bardelli Claudio , Morsanuto Vera , Ghirlanda Sabrina , Cochis Andrea , Molinari Claudio
Published: November 2016

The physiological effects of acetylcholine on keratinocytes depend on the presence of nicotinic and muscarinic receptors. The role of nonneuronal acetylcholine in keratinocytes could have important clinical implications for patients with various skin disorders such as nonhealing wounds. In order to evaluate the efficacy of highly diluted acetylcholine solutions obtained by sequential kinetic activation, we aimed to investigate the effects of these solutions on normal human keratinocytes. Two different concentrations (10 fg/mL and 1 pg/mL) and formulations (kinetically activated and nonkinetically activated) of acetylcholine were used to verify keratinocyte viability, proliferation, and migration and the intracellular pathways involved using MTT, crystal violet, wound healing, and Western blot compared to 147 ng/mL acetylcholine. The activated formulations (1 pg/mL and 10 fg/mL) revealed a significant capacity to increase migration, cell viability, and cell proliferation compared to 147 ng/mL acetylcholine, and these effects were more evident after a single administration. Sequential kinetic activation resulted in a statistically significant decrease in reactive oxygen species production accompanied by an increase in mitochondrial membrane potential and a decrease in oxygen consumption compared to 147 ng/mL acetylcholine. The M1 muscarinic receptor was involved in these effects. Finally, the involvement of ERK/mitogen-activated protein kinases (MAPK) and KI67 confirmed the effectiveness of the single treatment on cell proliferation. The intracellular pathways of calcium were investigated as well. Our results indicate for the first time that highly diluted and kinetically activated acetylcholine seems to play an active role in an in vitro model of wound healing. Moreover, the administration of acetylcholine within the physiological range may not only be effective but is also likely to be safe.
Crocetin Inhibits Lipopolysaccharide-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells
Authors: Song Lei , Kang Chen , Sun Yuan , Huang Wenrui , Liu Wei , Qian Zhiyu
Published: November 2016

Background/Aim: Crocetin is a readily bioavailable and bioactive compound extracted from Saffron. Previous studies indicated its various biomedical properties including antioxidant and anti-coagulation potencies. However, its effect on inflammation, notably within the cardiovascular system, has not been investigated yet. In the present study, we utilized human umbilical vein endothelial cell (HUVEC) to elucidate the effect of Crocetin on vascular inflammation. Methods: Cell viability and toxicity were evaluated by MTT and Lactate dehydrogenase (LDH) assay, respectively. Pro-inflammatory chemokine Monocyte Chemoattractant Protein-1 (MCP-1) and Interleukin-8 (IL-8) expressions were determined by RT-PCR and ELISA. With fluorescence labeled U937 cells, we examined immune cell adhesion to the inflamed HUVEC in vitro, which was further confirmed by the H&E staining in the murine subcutaneous endothelium in vivo. Results: Upon Lipopolysaccharide (LPS)-induced inflammatory response in HUVECs, Crocetin ameliorated cell cytotoxicity, suppressed MCP-1 and IL-8 expressions through blocking NF-κB p65 signaling transduction. Moreover, Crocetin inhibited immune cells adhesion and infiltration to inflamed endothelium, which is a key step in inflammatory vascular injury. Conclusions: These findings suggest that Crocetin, a natural herb extract, is a potent suppressor of vascular endothelial inflammation.
MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway
Authors: Yin Yuanqin , Li Fei , Shi Jing , Li Songlin , Cai Jingjing , Jiang Youhong
Published: November 2016

Background/Aims: The primary objective of this study was to investigate the role of miR-146a in inducing the inflammatory infiltration of macrophages in polymyositis/dermatomyositis (PM/DM) through targeting TNF receptor associated factor 6 (TRAF6), which may further down-regulate the Interleukin-17 (IL-17)/Intercellular Adhesion Molecule 1 (ICAM-1) pathway. Methods: Biopsies were collected from PM/DM patients and healthy volunteers. PM/DM model establishment and macrophage isolation were performed on Sprague Dawley (SD) rats. Model rats and macrophages were treated with anti-IL-17, anti-ICAM-1, miR-146a mimics, miR-146a inhibitors, and TRAF6 siRNAs. Serum creatine phosphokinase (S-CK) expression was assessed using double antibody sandwich enzyme-linked immunosorbent assay (ELISA) assay, and immunohistochemistry assay was performed to analyze CD163 expression in muscle samples. Furthermore, we used transwell assay to test cell migration; RT-PCR and western blot were carried out to determine the expression of miR-146a, TRAF6, IL-17, and ICAM-1. Results: The S-CK, TRAF6, IL-17 and ICAM-1 levels were higher in PM/DM patients compared with healthy controls and were down-regulated after the conventional treatment. Treatment with miR-146a mimics, anti-IL-17 and anti-ICAM-1 decreased the expression of IL-17 and ICAM-1, whereas miR-146a inhibitors exerted the opposite effects. The effects of miR-146a inhibitors were suppressed by treatment with TRAF6 siRNA. In addition, the luciferase reporter assay validated the targeting relationship between miR-146a and TRAF6. Conclusions: MiR-146a regulates inflammatory macrophage infiltration in PM/DM by targeting TRAF6 and affecting the IL-17/ICAM-1 pathway.
Stimulation of Suicidal Erythrocyte Death by Rottlerin
Authors: Mischitelli Morena , Jemaà Mohamed , Almasry Mustafa , Faggio Caterina , Lang Florian
Published: November 2016

Background/Aims: The phytochemical polyphenol rottlerin is a potent activator of diverse Ca2+ -sensitive K+ channels. Those channels play a decisive role in the execution of eryptosis, the suicidal death of erythrocytes, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signaling involved in the stimulation of eryptosis includes increase of cytosolic Ca2+ activity ([Ca2+]i) and ceramide. The present study explored, whether rottlerin induces eryptosis and, if so, to test for the involvement of Ca2+ entry and ceramide. Methods: Flow cytometry was employed to estimate phosphatidylserine exposure at the cell surface from annexin-V-binding, cell volume from forward scatter, [Ca2+]i from Fluo3-fluorescence, and ceramide abundance utilizing specific antibodies. Hemolysis was quantified by determination of haemoglobin concentration in the supernatant. Results: A 48 hours exposure of human erythrocytes to rottlerin (1 - 5 µM) significantly increased the percentage of annexin-V-binding cells, an effect paralleled by significant decrease of forward scatter. Up to 5 µM rottlerin failed to significantly increase average Fluo3-fluorescence. Rottlerin (5 µM) did, however, significantly increase the ceramide abundance. Rottlerin (5 µM) further significantly increased hemolysis. The effect of rottlerin (5 µM) on annexin-V-binding was virtually abolished by removal of extracellular Ca2+. Conclusions: Rottlerin stimulates eryptosis with erythrocyte shrinkage and phospholipid scrambling of the erythrocyte cell membrane, an effect paralleled by and at least in part due to Ca2+ entry and ceramide.
Sonodynamic Therapy Inhibits Fibrogenesis in Rat Cardiac Fibroblasts Induced by TGF-β1
Authors: Guo Yuanyuan , Dong Zengxiang , Shi Yuanqi , Wang Wei , Wang Lu , Sun Jing , Sun Xin , Tian Zhen , Yao Jianting , Li Zhitao , Cheng Jiali , Tian Ye
Published: November 2016

Background/Aims: Sonodynamic therapy (SDT) is a localized ultrasound-activated therapy for atherosclerosis when combined with a sonosensitizer, 5-aminolevulinic acid (ALA), but whether it can prevent cardiac fibrosis has not been studied. In the present study, we evaluated the effects SDT on fibrogenesis in rat cardiac fibroblasts. Methods: The primary cardiac fibroblasts were isolated from rats, and induced to fibrogenesis with TGF-β1. With this in vitro model, we tested the preventive effects of SDT on fibrogenesis and further the underlying mechanism. Results: TGF-β1 stimulation up-regulated α-SMA and COLI/III protein levels in cardiac fibroblasts, and enhanced the progression of cells from the G0/G1 phase to the S phase. SDT inhibited the TGF-β1 mediated cell proliferation and decreased the levels of α-SMA and COLI/III by activating AKT/GSK3β pathway and blocking TGF-β1/SMAD3 signaling. Conclusion: Our studies demonstrate an antifibrotic effect of SDT in rat cardiac fibroblasts, suggesting that SDT may intervene cardiac fibrogenesis by regulating myocardial fibrotic remodeling.
Left-Ventricular Plication Reduces Wall Stress and Cardiomyocyte Hypertrophy in a Rat Model of Ischemic Cardiomyopathy
Authors: Asai Hidetsugu , Shingu Yasushige , Yamakawa Tomoji , Niwano Haruki , Wakasa Satoru , Ooka Tomonori , Kato Hiroki , Tachibana Tsuyoshi , Matsui Yoshiro
Published: November 2016

Background: The indications of left-ventricular plication (LVP) are controversial, although several studies have reported favorable outcomes in heart failure patients. The aim of this study was to assess left-ventricular (LV) wall stress and myocardial remodeling after LVP in a rat model of myocardial infarction (MI). Methods: Sixteen rats underwent LVP by excluding the LV anterior wall scar 4 weeks after ligation of the left anterior descending artery. After 4 weeks, LV wall stress was assessed using transthoracic echocardiography and an LV catheter. Gene expression of the wall stress markers, atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP), were evaluated via reverse transcription polymerase chain reaction. Cardiomyocyte area and myocardial fibrosis were also examined through histological examinations. These parameters were compared to those in 16 rats that underwent coronary artery ligation but not LVP. Results: We noted that the LV end-diastolic dimension was smaller (9.9 ± 0.3 vs. 11.2 ± 0.2 mm, p < 0.05) and fractional shortening was greater (25 ± 2 vs. 15 ± 1%, p < 0.05) in LVP rats than in sham rats. Moreover, systolic wall stress was lower in LVP rats (71 ± 7 vs. 111 ± 9 × 103 dyn/cm2, p < 0.05). Myocardial ANF and BNP expression levels were lower in LVP rats (2.6 ± 0.3 vs. 4.4 ± 0.5 and 1.0 ± 0.1 vs. 1.5 ± 0.2 arbitrary units, respectively; p < 0.05). Cardiomyocyte area was significantly decreased in LVP rats (556 ± 15 vs. 670 ± 28 μm2, p = 0.003) and was correlated with LV wall stress (r = 0.669, p = 0.002). The reduction in myocardial fibrosis after LVP was not significant. Conclusion: LVP reduced LV wall stress and cardiomyocyte hypertrophy in a rat model of MI.
17p13.3 Microdeletion: Insights on Genotype-Phenotype Correlation
Authors: Barros Fontes Marshall I. , dos Santos Ana P. , Rossi Torres Fábio , Lopes-Cendes Iscia , Cendes Fernando , Appenzeller Simone , Kawasaki de Araujo Tânia , Lopes Monlleó Isabella , Gil-da-Silva-Lopes Vera L.
Published: November 2016

Microdeletions in the chromosomal region 17p13.3 are associated with neuronal migration disorders, and PAFAB1H1 is the main gene involved. The largest genomic imbalances, including the YWHAE and CRK genes, cause more severe structural abnormalities of the brain and other associated dysmorphic features. Here, we describe a 3-year-old boy with a microdeletion in 17p13.3 presenting with minor facial dysmorphisms, a cleft palate, neurodevelopmental delay, and behavioral disorder with no structural malformation of the brain. The patient was evaluated by a clinician using a standard protocol. Laboratory investigation included GTG-banding, whole-genome AGH, and array-CGH. Whole-genome AGH and array-CGH analysis identified an estimated 2.1-Mb deletion in the 17p13.3 region showing haploinsufficiency of the YWHAE, CRK, H1C1, and OVCA1 genes and no deletion of PAFAH1B1. The complex gene interaction on brain development and function is illustrated in the genotype-phenotype correlation described here. This report reinforces the importance of the 17p13.3 region in developmental abnormalities and highlights the weak implication of the HIC1 and OVCA1 genes in palatogenesis.
Plasma levels of the anti-coagulation protein C and the risk of ischaemic heart disease
Authors: Schooling C. Mary , Zhong Yi
Published: November 2016

Protein C is an environmentally modifiable anticoagulant, which protects against venous thrombosis, whether it also protects against ischaemic heart disease is unclear, based on observational studies and relatively small genetic studies. It was our study aim to clarify the role of protein C in ischaemic heart disease. The risk of coronary artery disease/myocardial infarction (CAD/MI) was assessed according to genetically predicted protein C in very large studies. Associations with lipids and diabetes were similarly assessed to rule out effects via traditional cardiovascular disease risk factors. Separate sample instrumental variable analysis with genetic instruments (Mendelian randomisation) was used to obtain an unconfounded estimate of the association of protein C (based on (rs867186 (PROCR), rs3746429 (EDEM2), rs7580658 (inter/PROC)) with CAD/MI in an extensively genotyped case (n=64374)-control (n=130681) study, CARDIoGRAMplusC4D. Associations with lipids and diabetes were similarly assessed using the Global Lipids Genetics Consortium Results (n=196,475) and the DIAbetes Genetics Replication And Meta-analysis case (n=34,380)-control (n=114,981) study. Genetically predicted protein C was negatively associated with CAD/MI, odds ratio (OR) 0.85 µg/ml, 95 % confidence interval 0.80 to 0.90, but had no such negative association with lipids or diabetes. Results were similar for the SNP rs867186 functionally relevant to protein C, and including additional potentially pleiotropic SNPs (rs1260326 (GCKR), rs17145713 (BAZ1B) and rs4321325 (CYP27C1)). In conclusion, protein C may protect against CAD/MI. Whether environmental or dietary items that raise protein C protect against ischaemic cardiovascular disease by that mechanism should be investigated.

Supplementary Material to this article is available online at www.thrombosis-online.com.
Representação político-eleitoral no Peru: fragmentação e construção partidária (2001-2016)
Authors: Panfichi Aldo , Dolores Juan
Published: November 2016

Since 2000, Peruvian democracy has gone through four sub-national electoral processes and four presidential elections. Yet, Peru is still considered to have one of the most politically volatile and fragmented political systems in the region. This is due in part to the considerable distance between the players in the game, the political dynamics and the local and national electoral results. Nationallevel parties have nearly disappeared in Peru’s 25 separate political regions, and have been replaced largely by regional movements loosely linked to each other. However, a more detailed analysis suggests two relatively recent parties, Fuerza Popular (Keiko Fujimori) and Alianza para el Progreso (César Acuña) are developing more sustained − albeit different − strategies for party construction with serious prospects for national-level representation. This article explores these developments and proposes some explanatory hypotheses in this respect
A democracia no México
Authors: Valenzuela Rubén Aguilar
Published: November 2016

When the armed phase of the Mexican Revolution (1910-1920) came to an end, the winning group developed a political system which allowed for dissolving power institutionally, and which was characterized by a presidential system, a State party and corporatism. In 1977, a process of democratic transition was started; and it ended in 2000 with the victory of Vicente Fox, the opposing candidate. The 80-year-long period of an authoritarian, albeit not dictatorial, regime was ended. Today an intense electoral competitiveness is a reality. Now Mexican democracy is faced with an array of bigger challenges it needs to overcome in a short period of time to consolidate and streamline the system. Three of the biggest challenges are: rooting out corruption, reducing the levels of social inequality, and expanding spaces for citizen participation
Analysis of resource catchment of the Mineração site area.
Authors: Scatamacchia Maria Cristina Mineiro , Amenomori Sandra Nami , Bustamante Alejandra , Franchi Cleide , Cali Plácido
Published: November 2016

O objetivo é apresentar o trabalho que estamos desenvolvendo sobre a área de captação de rceursos de grupos horticultores do baixo vale do Ribeira. Estamos adaptando a abordagem de "site catchnicnt analysis" originalmente proposta por Vita Finzi e Higgs (1970), tendo como ponto de partida o sítio Mineração, Icapara, Iguapè, S.P. Foi feita uma primeira tentativa de reconstituir um ciclo de subsistência anual, que deverá ser testado cm outras aldeias da região.
Ceramists cultures of São Paulo and Minas Gerais: technical typological study.
Authors: Alves Márcia Angelina
Published: November 2016

Este artigo trata da detecção e evidenciação de quatro sítios arqueológicos estando dois, FRANCO DE GODOY e LAGOA SÃO PAULO, localizados no Estado de São Paulo, os outros dois, PRADO e SILVA SERROTE, situados no Estado de Minas Gerais, cujos conjuntos cerâmicos foram estudados em seus contextos espaciais, à luz da metodologia de "Superfícies Amplas" de Leroi-Gourhan, a nível tecnolipológico. Neste estudo aplicaram-se a classificação tipológica e análises por microscopía petrográfica (de luz transmitida), difratomclria de raios-X e microscopía eletrônica que resultaram na elaboração de urna tese de Doutorado "ANÁLISE CERÂMICA: ESTUDO TECNOTIPOLÓGICO" defendida junto à Universidade de São Paulo, em 19S8. Neste artigo foram destacadas a metodologia, as escavações associadas às estruturas dos sítios e o estudo tipológico dos quatro conjuntos.
The manufacture of bronze vessels as concentration of techniques applied in the fabrication of other categories of bronze objects.
Authors: Fleming Maria Isabel D ’Agostino
Published: November 2016

O vasilhame de bronze produzido 110 final do período republicano romano e início do período imperial é proposto como uma fonte de experiências técnicas difundidas e absorvidas na fabricação de outros objetos que possuem, paralelos com os elementos que compõem as vasilhas: estatuetas, medalhões ou apliques, espelhos, bases de estatuetas, de candelabros e assemelhados. Na análise de cada um dos elementos das vasilhas — alças, elementos de sustentação das alças ou medalhões e fundos — e de seus respectivos paralelos nas demais categorias de objetos, levou-se em consideração tanto os aspectos técnicos como os elementos estilísticos e as tradições artísticas e iconográficas para obter o quadro das inter-relações dessas manufaturas baseadas 110 trabalho especializado.
Contemporary archaeologists: an alternative experience.
Authors: Alvares Rita de Cássia
Published: November 2016

Este artigo apresenta uma experiência realizada com alunos da Escola Pública de São Paulo, que inclui a visita monitorada ao MAE-USP. O objetivo desse trabalho é divulgar alguns procedimentos pedagógicos, bem como os resultados obtidos com a exploração dos artefatos como documentos.
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Authors: Marois Roger
Published: November 2016

Os participantes do National Symposium for the Development of Database Standards for Archaeological Collections Management, ocorrido em 1987, na cidade de Fayetteville, Arkansas, descobriram que a partir dos princípios de organização elaborados para cada programação institucional, toma-se impossível fazer um único programa nacional. Além disso, este artigo apresenta exemplos para demonstrar a necessidade de definir os termos arqueológicos especializados com maior precisão.
La antigüedad del Hombre en el nordeste de Brasil
Authors: Martin Gabriela
Published: November 2016

Entre os pré-historiadores americanistas existem várias tendencias em relação à antiguidade do povoamento americano. As mais conservadoras não aceitam o povoamento do continente em datas anteriores a 20.000 anos e as mais avançadas chegam a admitir a possibilidade do homo erectus ter chegado à América 200 ou 300 mil anos atrás. Neste artigo resume-se os dados cronológicos conhecidos em relação a esse tema em comparação aos dados relativos ao Nordeste do Brasil.
Contribuições arqueológicas, etnoarqueológicas e etno-históricas para o estudo dos grupos tribais do Brasil Central: o caso Bororo
Authors: Wüst Irmhild
Published: November 2016

As evidências arqueológicas, etnoarqueológicas e etnohistóricas sugerem que os índios Bororo do sudeste do Mato Grosso resultaram da fusão de grupos étnicos e culturais distintos. A ruptura com os agricultores da tradição Uru, que ocuparam anteriormente esta área, é explicada em termos de pressões internas e externas e do predomínio político de um grupo provavelmente minoritário, portador de uma nova estratégia de subsistência, padrão de assentamento e tecnologia, instaurando-se uma nova ordem social a um nível de integração regional mais amplo, dramaticamente interrompido a partir dos primeiros contatos diretos com a sociedade nacional.
As estruturas arqueológicas do Alto Paranaíba e Triângulo Mineiro - Minas Gerais
Authors: Alves Marcia Angelina
Published: November 2016

O presente artigo apresenta as estruturas arqueológicas (associadas à estratigrafía e às datações) das regiões do ALTO PARANAÍBA e TRIANGULO MINEIRO, Estado de Minas Gerais, detectadas e evidenciadas pelo projeto de pré-história “QUEBRA ANZOL”, criado em 1980. Este projeto baseia-se na execução de um programa de PROSPECÇÕES e ESCAVAÇÕES sistemáticas que, em doze anos de pesquisa, possibilitou escavar seis sítios arqueológicos - PRADO, SILVA SERROTE, INHAZINHA, REZENDE, MENEZES e RODRIGUES FURTADO, objetivando a obtenção de uma ampla visão da arqueologia do Vale do Paranaíba, Minas Gerais.
As propriedades físicas dos arenitos silicificados e suas implicações na aptidão ao lascamento
Authors: Araújo Astolfo Gomes de Mello
Published: November 2016

Este artigo visa .apresentar alguns resultados obtidos a partir do estudo de seções delgadas de arenitos silicificados, matéria-prima abundante na região sudeste do Brasil. Foram comparadas cinco amostras de arenito silicificado com diferentes graus de aptidão ao lascamento e buscadas as relações entre essa aptidão e as características físicas das amostras (arredondamento, esfericidade, granulometria etc.). Os resultados obtidos corroboraram algumas hipóteses levantadas a respeitodessas relações e abriram uma perspectiva para o estudo do comportamento físico deste tipo de matéria-prima.
Herbert Baldus: vida e obra — Introdução ao indigenismo de um americanista teuto-brasileiro
Authors: Sampaio-Silva Orlando
Published: November 2016

Herbert Baldus foi um antropólogo teuto-brasileiro que exerceu importante papel na constituição da pesquisa e dos conhecimentos antropológicos no Brasil. Seu trabalho científico se desenvolveu intimamente ligado ao curso de sua própria vida, que transcorreu, em sua maior parte, neste país, dedicada ao ensino, à pesquisa, à divulgação científica e à tentativa de instituir uma política indigenista comprometida com a preservação das etnias indígenas. A contribuição de seu pensamento teórico, tendo iniciado com explanações sobre as culturas materiais e não materiais, passou por abordagens funcionalistas e estruturalistas, lançando as bases dos estudos das sociedades indígenas em situação de contato e de mudança cultural.
Coleções etnográficas brasileiras em Stuttgart: histórico e composição
Authors: Schumann Leonor , Hartmann Thekla
Published: November 2016

Parte de um amplo projeto de levantamento dos materiais etnográficos brasileiros existentes em museus nacionais e do Exterior, este artigo apresenta o acervo correspondente do Museu de Etnologia de Stuttgart, Alemanha, organizado por tribo, fornecendo ainda alguns dados sobre formas de aquisição, bem como rápidos perfis biográficos de seus coletores/doadores.
CRÔNICA DO MUSEU - Ano de 1991
Authors: MAE/USP Museu de Arqueologia e Etnologia
Published: November 2016

CRÔNICA DO MUSEU - Ano de 1991
Poiein - graphein: the social status of the craftsmen-artists o f Attic vases.
Authors: Sariart Haiganuch
Published: November 2016

A produção de vasos áticos foi das mais importantes da antiguidade em qualidade e volume num longo período que vai do séc. VI ao IV a.C. P oiein- gráphein, “fazer e pintar”, foram as duas operações a que se dedicaram os artesãos-artistas destes vasos de Atenas e de sua região. Pretendese com este trabalho definir, com o exame de alguns vasos e da tradição literária e epigráfica, o papel desempenhado na sociedade ateniense por estes artesãosartistas, bem como o estatuto social da atividade manual dentro de uma específica ideologia do trabalho.
Symbols o f power in the proverbs and graphic representations M abaya M anzangu ofthe Bawoyo o f Cabinda-Angola.
Authors: Serrano Carlos
Published: November 2016

O autor analisa alguns sím bolos do poder associados a representações gráficas esculpidas em tampas de panela {Mabaya Manzangu) e a enunciação de provérbios utilizados entre os Bawoyo de Cabinda (Angola) como processo ritual de solucionar tensões e conflitos familiares.
Commentaries on some South American Indian drugs and related paraphernalia.
Authors: Wassé S. Henry
Published: November 2016

Revisão dos progressos nas pesquisas sobre substâncias psicoativas usadas por populações sul-americanas, pré-históricas e atuais, com destaque para as associações da parafernália empregada com o mundo animal.
Considerations on the profile of the MAE-USP African and Afro-Brazilian collection.
Authors: Salum Marta Heloisa Leuba , Ceravolo Suely Moraes
Published: November 2016

Este estudo visa a reunir dados ainda não publicados sobre o acervo referente à África no MAE - Museu de Arqueologia e Etnologia (Universidade de São Paulo), relacionando-o ao seu aproveitamento educacional e científico. Trata-se de uma reflexão acumulada durante o trabalho com a Coleção no período de 1981 a 1992, com o objetivo de dar uma contribuição inicial para a memória dessa Coleção na Universidade
Excavations in the theoretic field: archaeology, anthropology and history... or the Classical Archaeology affer New Archaeology.
Authors: Trindade-Serra Ordep J.
Published: November 2016

Discute-se neste artigo o papel da New Archaeology na evolução teórica e metodológica da disciplina e o seu possível contributo para o desenvolvimento da arqueologia clássica, na atualidade. Procura-se também apreciar a situação da arqueologia clássica no presente contexto, em que a New Archaeology sofre revisão e dá lugar a uma rica floração “pós-moderna” de enfoques da problemática arqueológica. Para esclarecer estes pontos, focaliza-se as relações entre arqueologia, antropologia e história.
Interpretation proposal of a divine statue - Cairo CG 38068.
Authors: Brancaglion Junior Antonio
Published: November 2016

Trata-se de uma uma reinterpretação de uma estátua divina considerada como uma representação do deus Tatunem (Maspero/Vandier) ou como uma forma do deus Ámon (Russman). Entretanto, a partir de uma análise global de seus atributos demonstrou-se ser idêntica a uma forma do deus Osíris-Seker, presente em uma das cenas da tumba do rei Sheshonq III em Tânis.
Amixokori, Pataxó, Monoxó, Kumanoxó, Kutaxó, Kutatoi, Maxakali, Malali and Makoni: indian peoples or differentiated Subgroups of a same Nation? A reflection proposal.
Authors: Paraíso Maria Hilda Baqueiro
Published: November 2016

Procuramos discutir a questão da identidade étnica dos vários grupos indígenas que habitaram o sul da Bahia, norte do Espírito Santo e nordeste de Minas Gerais nos séculos XVIII e XIX. Usamos, para tanto, dados fornecidos pelos estudos arqueológicos, lingüísticos, históricos e antropológicos, procurando cruzá-los de forma a testar a nossa hipótese de que, sob diferentes designações, o que temos são subgrupos de uma mesma nação: Tikmu’nu
La arqueologia urbana en la Colonia del Sacramento.
Authors: Zambetogliris Nelsys Fusco
Published: November 2016

Este artigo aborda vários projetos de pesquisa realizados na Colônia de Sacramento (Uruguai). Trata-se de um projeto de arqueologia tanto urbana quanto histórica. Foi desenvolvido na própria cidade, fundada pelos portugueses em 1690 e posteriormente controlada pelos espanhóis por mais um século. O período histórico que se inicia no séc. XVI está sendo estudado. A evolução do desenvolvimento urbano foi nosso principal objetivo e novas metodologias foram implementadas.
Potential resources of hunter-gatherers groups in middle Ribeira River (SP).
Authors: Bissa Walter Mareschi , Mantovani Waldir
Published: November 2016

Estudos fitossociológicos realizados em duas áreas no domínio das florestas tropicais do médio vale do Rio Ribeira mostram que a região apresenta grande homogeneidade ecológica, embora existam diferenças locais. As condições clim áticas e topográficas da região eram propícias para o assentamento de caçadores-coletores, que dispunham de uma variedade ampla de recursos vegetais existentes, notadamente frutos, nas diversas épocas do ano.
Analysing local settlement systems: an experience with full-coverage survey in the middle Ribeira Valley, São Paulo State
Authors: De Blasis Paulo A. D. , Morales Walter F.
Published: November 2016

Este artigo discute a abordagem metodológica de uma pesquisa arqueológica realizada em um pequeno vale situado na bacia do médio Ribeira, sul do Estado de São Paulo, uma área bastante montanhosa e densamente florestada. O objetivo principal do projeto é investigar as características locais de um sistema de assentamento formado por agrupamentos de sítios líticos de ampla dispersão regional, assim como examinar os padrões de uso do espaço de uma comunidade rural contemporânea (o Bairro da Serra) que hoje ocupa o mesmo local. Em função da baixa visibilidade dos vestígios arqueológicos, um programa de prospecção de cobertura total (full-coverage survey), com uma malha sistemática de testes de sub-superfície, foi aplicado em todo o vale, com excelentes resultados em termos da evidenciação de diferentes unidades de assentamento (inclusive a presença de um horizonte de ocupação do período cerâmico antes desconhecido) e seus padrões de distribuição.
‘Sizanga’.
Authors: Leite Fábio
Published: November 2016

Este texto aborda alguns aspectos de ‘Sizanga’ (Bosque Sagrado), aparato social dos Senufo, sociedade negro-africana, e das relações que estabelece no universo das práticas históricas, revelando formas de percepção e organização da realidade segundo valores originários definidores da identidade profunda dessa civilização.
Axexe: a rite of passage.
Authors: Manzochi Helmy Mansur
Published: November 2016

Neste artigo descrevemos a cerimônia do Axexê, observada no terreiro de Candomblé “Ilê Olorum Wam Be”, em São Paulo, em 1991. Ela é celebrada quando morre uma pessoa importante da comunidade. Na concepção africana, a morte não significa a extinção total, mas uma mudança de plano de existência e de status, para se chegar ao “estado ancestral”.
Traditional museums at contemporary society: a revision
Authors: Bottallo Marilúcia
Published: November 2016

Através de uma contextualização histórica do surgimento do museu tradicional na nossa cultura, busca-se refletir sobre seu papel social e cultural na contemporaneidade, deslocando o eixo da discussão dos objetos para o público, tomando-o meta principal de interesse.