bluuebunny/crossref_metadata_2025 huggingface dataset:
In Vitro Comparative Study of Near-Infrared Photoimmunotherapy and Photodynamic Therapy
Authors: Yamashita Susumu , Kojima Miho , Onda Nobuhiko , Shibutani Makoto
Published: June 2023

Near-infrared photoimmunotherapy (NIR-PIT) is a new phototherapy that utilizes a monoclonal antibody (mAb) against cancer antigens and a phthalocyanine dye, IRDye700DX (IR700) conjugate (mAb-IR700). Photodynamic therapy (PDT) is a combination therapy that utilizes photoreactive agents and light irradiation as well as NIR-PIT. In the present study, we compared these therapies in vitro. The characterization of cellular binding/uptake specificity and cytotoxicity were examined using two mAb-IR700 forms and a conventional PDT agent, talaporfin sodium, in three cell lines. As designed, mAb-IR700 had high molecular selectivity and visualized target molecule-positive cells at the lowest concentration examined. NIR-PIT induced necrosis and damage-associated molecular patterns (DAMPs), a surrogate maker of immunogenic cell death. In contrast, talaporfin sodium was taken up by cells regardless of cell type, and its uptake was enhanced in a concentration-dependent manner. PDT induced cell death, with the pattern of cell death shifting from apoptosis to necrosis depending on the concentration of the photosensitizer. Induction of DAMPs was observed at the highest concentration, but their sensitivity differed among cell lines. Overall, our data suggest that molecule-specific NIR-PIT may have potential advantages compared with PDT in terms of the efficiency of tumor visualization and induction of DAMPs.
Aggressive Angiomyxoma of the Lower Female Genital Tract in Pregnancy: A Review of the MITO Rare Tumors Group
Authors: Cicogna Stefania , Dellino Miriam , Miano Salvatora Tindara , Magazzino Francescapaola , Domenici Lavinia , Pignata Sandro , Mangili Giorgia , Cormio Gennaro
Published: June 2023

Deep (aggressive) angiomyxoma of the lower genital tract is a rare malignancy affecting women of reproductive age. Being a hormone-sensitive tumor, its growth is particularly benefitted during pregnancy. Surgical excision with complete resection is indicated, even if a wait-and-see approach can be considered until delivery, to avoid destructive surgeries. The mode of delivery is to be evaluated based on the location and size of the neoplasm; vaginal delivery is not contraindicated, as long as the tumor does not obstruct the birth canal. Positive surgical margins are the most important prognostic factor for recurrence. Adjuvant therapy with gonadotropin-releasing hormone analogues may be proposed after pregnancy, in the case of non-radical surgery. Despite the high local relapse rate, the outcomes for mother and child are favorable. Since recurrences can occur after many years, the patient should be included in long-term follow-up.
Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9
Authors: Chan Chilam , Lustig Marta , Jansen J. H. Marco , Garcia Villagrasa Laura , Raymakers Leon , Daamen Lois A. , Valerius Thomas , van Tetering Geert , Leusen Jeanette H. W.
Published: June 2023

Immunotherapy with targeted therapeutic antibodies is often ineffective in long-term responses in cancer patients due to resistance mechanisms such as overexpression of checkpoint molecules. Similar to T lymphocytes, myeloid immune cells express inhibitory checkpoint receptors that interact with ligands overexpressed on cancer cells, contributing to treatment resistance. While CD47/SIRPα-axis inhibitors in combination with IgA therapy have shown promise, complete tumor eradication remains a challenge, indicating the presence of other checkpoints. We investigated hypersialylation on the tumor cell surface as a potential myeloid checkpoint and found that hypersialylated cancer cells inhibit neutrophil-mediated tumor killing through interactions with sialic acid-binding immunoglobulin-like lectins (Siglecs). To enhance antibody-dependent cellular cytotoxicity (ADCC) using IgA as therapeutic, we explored strategies to disrupt the interaction between tumor cell sialoglycans and Siglecs expressed on neutrophils. We identified Siglec-9 as the primary inhibitory receptor, with Siglec-7 also playing a role to a lesser extent. Blocking Siglec-9 enhanced IgA-mediated ADCC by neutrophils. Concurrent expression of multiple checkpoint ligands necessitated a multi-checkpoint-blocking approach. In certain cancer cell lines, combining CD47 blockade with desialylation improved IgA-mediated ADCC, effectively overcoming resistance that remained when blocking only one checkpoint interaction. Our findings suggest that a combination of CD47 blockade and desialylation may be necessary to optimize cancer immunotherapy, considering the upregulation of checkpoint molecules by tumor cells to evade immune surveillance.
High-Performance Sr0.95Fe0.8Mo0.1Ni0.1O3−δ Electrode for Reversible Symmetrical Solid Oxide Cells
Authors: Gong Yudong , Wang Jinyi , Bian Liuzhen , Wang Yige , Wang Fan , Guo Weiqi , Wu Zhan
Published: June 2023

Reversible symmetrical solid oxide cells (RS-SOCs) have attracted much attention due to their high energy conversion efficiency and fabrication simplicity. In this study, 10% Fe was substituted with Ni in the B-site of Sr0.9Fe0.9Mo0.1O3−δ to enhance the electrochemical performance of H2O electrolysis. The characterization results and theoretical calculations indicated that Ni doping decreased the adsorption and reaction energy barrier of intermediates of H2O electrolysis on the Sr0.95Fe0.8Mo0.1Ni0.1O3−δ’s (111) surface, which promoted the kinetics of the electrode reaction, thus fabricating electrochemical activity and resulting in higher reaction dynamics. Consequently, a high power density of 1.145 W cm−2 at 850 °C on a symmetrical cell was achieved in the solid oxide fuel cell (SOFC) mode, and a current density of 3.995 A cm−2 was obtained at 850 °C and 1.6 V in the solid oxide electrolysis cell (SOEC) mode, indicating the Sr0.9Fe0.8Mo0.1Ni0.1O3−δ oxide to be a promising SOFC electrode for power production and SOEC electrode for H2 production.
Synthesis of Asymmetrical CsPbBr3/TiO2 Nanocrystals with Enhanced Stability and Photocatalytic Properties
Authors: Liu Wanli , Liu Jinfeng , Wang Xiaoqian , He Jiazhen , Li Yuqing , Liu Yong
Published: June 2023

Practical applications of CsPbX3 nanocrystals (NCs) are limited by their poor stability. The formation of a heterojunction between CsPbX3 NCs and oxides is an effective means to protect perovskite from polar solvents and other external factors. Significantly improving the stability and photocatalytic properties of the core/shell perovskite is very important for its application in photoelectric and photocatalytic technology. Here, we report the synthesis of asymmetrical CsPbBr3/TiO2 core–shell heterostructure NCs at the single-particle level by hot-injection liquid-phase synthesis and sol–gel method, where each CsPbBr3 NCs is partially covered by titanium dioxide. We tested not only the optical properties of the material but also the electrochemical impedance and photocurrent density of the material in sodium sulfate solution. It is shown that the type II arrangement is generated at the heterogeneous interface, which greatly facilitates the separation of electron–hole pairs and increases the carrier transport efficiency. Compared with CsPbBr3 NCs, CsPbBr3/TiO2 has higher photocatalytic efficiency. More crucially, due to the protection of the titanium dioxide shell, the product has higher long-term stability in humid air compared with bare CsPbBr3 NCs. The asymmetrical core–shell heterostructure prepared in this study not only improves the stability of CsPbX3 NCs but also provides some ideas for optoelectronic device applications and TiO2-based photocatalysts.
Size Effect on Diffusion and Catalytic Performance of Mordenite in Dimethyl Ether Carbonylation
Authors: Dong Chenchen , Liu Yunduo , Xia Yumeng , Liu Hu , Zhang Yan , Huang Shouying , Ma Xinbin
Published: June 2023

The carbonylation of dimethyl ether (DME) to produce methyl acetate (MA) has a promising prospect in industry. Mordenite (MOR) has been widely studied due to its excellent catalytic activity and high MA selectivity; however, its microporous characteristic limits the intracrystalline diffusion that influences the activity and stability. Therefore, it becomes essential to clarify the relationship between catalytic activity and diffusion. In this study, a series of MOR samples with similar Si/Al contents and aspect ratios, but different sizes, were successfully synthesized by adjusting the synthesis parameters (Si/Al contents in gel, aging time, the amount of water, and alkalinity). Based on quantitative analysis of acid properties and catalyst evaluation, both the apparent turnover frequency of MA (TOFMA) and the stability decrease with the increase in particle size. Diffusion parameter measurements and kinetic analysis via zero length column methods show that the intracrystalline diffusion restriction becomes more serious with increasing particle size. The larger the MOR crystals with enhanced mass transfer limitation that undergo lower activity, the higher the selectivity of byproducts, as well as the faster their deactivation.
Ag-Cu Nanoparticles as Cathodic Catalysts for an Anion Exchange Membrane Fuel Cell
Authors: Beltrán-Gastélum Mara , Portillo-Fuentes Samantha Goretti , Flores-Hernández José Roberto , Salazar-Gastélum Moisés Israel , Trujillo-Navarrete Balter , Romero-Castañón Tatiana , Silva-Carrillo Carolina , Reynoso-Soto Edgar Alonso , Félix-Navarro Rosa María
Published: June 2023

In this work, the synthesis of bimetallic Ag and Cu particles on carbon vulcan (AgCu/C) is reported, synthesized by a simple galvanic displacement method using citrate tribasic hydrate as a co-reducing agent and a commercial material based on Cu/C as a template. The materials were characterized by several physicochemical techniques, including TGA, ICP-OES, XRD, SEM, and BET. The catalysts were evaluated as cathodic catalysts for the oxygen reduction reaction (ORR) and were used for the preparation of membrane electrode assemblies for evaluation in an Anion Exchange Membrane Fuel Cell (AEMFC). The results were compared with the commercial Ag/C and Cu/C catalysts; the bimetallic catalyst obtained a higher power density, which was attributed to a synergistic effect between Ag and Cu particles.
Global Analysis of Transcription Start Sites and Enhancers in Endometrial Stromal Cells and Differences Associated with Endometriosis
Authors: Marla Sushma , Mortlock Sally , Yoon Sohye , Crawford Joanna , Andersen Stacey , Mueller Michael D. , McKinnon Brett , Nguyen Quan , Montgomery Grant W.
Published: June 2023

Identifying tissue-specific molecular signatures of active regulatory elements is critical to understanding gene regulatory mechanisms. In this study, transcription start sites (TSS) and enhancers were identified using Cap analysis of gene expression (CAGE) across endometrial stromal cell (ESC) samples obtained from women with (n = 4) and without endometriosis (n = 4). ESC TSSs and enhancers were compared to those reported in other tissue and cell types in FANTOM5 and were integrated with RNA-seq and ATAC-seq data from the same samples for regulatory activity and network analyses. CAGE tag count differences between women with and without endometriosis were statistically tested and tags within close proximity to genetic variants associated with endometriosis risk were identified. Over 90% of tag clusters mapping to promoters were observed in cells and tissues in FANTOM5. However, some potential cell-type-specific promoters and enhancers were also observed. Regions of open chromatin identified using ATAC-seq provided further evidence of the active transcriptional regions identified by CAGE. Despite the small sample number, there was evidence of differences associated with endometriosis at 210 consensus clusters, including IGFBP5, CALD1 and OXTR. ESC TSSs were also located within loci associated with endometriosis risk from genome-wide association studies. This study provides novel evidence of transcriptional differences in endometrial stromal cells associated with endometriosis and provides a valuable cell-type specific resource of active TSSs and enhancers in endometrial stromal cells.
Dopamine Transporter Deficiency Syndrome (DTDS): Expanding the Clinical Phenotype and Precision Medicine Approaches
Authors: Ng Joanne , Barral Serena , Waddington Simon N. , Kurian Manju A.
Published: June 2023

Infantile parkinsonism-dystonia due to dopamine transporter deficiency syndrome (DTDS) is an ultrarare childhood movement disorder caused by biallelic loss-of-function mutations in the SLC6A3 gene. Advances in genomic analysis have revealed an evolving spectrum of SLC6A3-related neurological and neuropsychiatric disorders. Since the initial clinical and genetic characterisation of DTDS in 2009, there have been thirty-one published cases with a variety of protein-truncating variants (nonsense variants, splice-site changes, and deletions) and missense changes. Amino acid substitutions result in mutant proteins with impaired dopamine transporter function due to reduced transporter activity, impaired dopamine binding, reduced cell-surface expression, and aberrant posttranslational protein modification with impaired glycosylation. In this review, we provide an overview of the expanding clinical phenotype of DTDS and the precision therapies in development, including pharmacochaperones and gene therapy.
Sterol Regulation of Development and 20-Hydroxyecdysone Biosynthetic and Signaling Genes in Drosophila melanogaster
Authors: Wen Di , Chen Zhi , Wen Jiamin , Jia Qiangqiang
Published: June 2023

Ecdysteroids are crucial in regulating the growth and development of insects. In the fruit fly Drosophila melanogaster, both C27 and C28 ecdysteroids have been identified. While the biosynthetic pathway of the C27 ecdysteroid 20-hydroxyecdysone (20E) from cholesterol is relatively well understood, the biosynthetic pathway of C28 ecdysteroids from C28 or C29 dietary sterols remains unknown. In this study, we found that different dietary sterols (including the C27 sterols cholesterol and 7-dehydrocholesterol, the C28 sterols brassicasterol, campesterol, and ergosterol, and the C29 sterols β-sitosterol, α-spinasterol, and stigmasterol) differentially affected the expression of 20E biosynthetic genes to varying degrees, but similarly activated 20E primary response gene expression in D. melanogaster Kc cells. We also found that a single dietary sterol was sufficient to support D. melanogaster growth and development. Furthermore, the expression levels of some 20E biosynthetic genes were significantly altered, whereas the expression of 20E signaling primary response genes remained unaffected when flies were reared on lipid-depleted diets supplemented with single sterol types. Overall, our study provided preliminary clues to suggest that the same enzymatic system responsible for the classical C27 ecdysteroid 20E biosynthetic pathway also participated in the conversion of C28 and C29 dietary sterols into C28 ecdysteroids.
Methylglyoxal Impairs the Pro-Angiogenic Ability of Mouse Adipose-Derived Stem Cells (mADSCs) via a Senescence-Associated Mechanism
Authors: Leone Alessia , Nicolò Antonella , Prevenzano Immacolata , Zatterale Federica , Longo Michele , Desiderio Antonella , Spinelli Rosa , Campitelli Michele , Conza Domenico , Raciti Gregory Alexander , Beguinot Francesco , Nigro Cecilia , Miele Claudia
Published: June 2023

Adipose-derived stem cells (ADSCs) play a crucial role in angiogenesis and repair of damaged tissues. However, in pathological conditions including diabetes, ADSC function is compromised. This work aims at evaluating the effect of Methylglyoxal (MGO), a product of chronic hyperglycemia, on mouse ADSCs’ (mADSCs) pro-angiogenic function and the molecular mediators involved. The mADSCs were isolated from C57bl6 mice. MGO-adducts and p-p38 MAPK protein levels were evaluated by Western Blot. Human retinal endothelial cell (hREC) migration was analyzed by transwell assays. Gene expression was measured by qRT-PCR, and SA-βGal activity by cytofluorimetry. Soluble factor release was evaluated by multiplex assay. MGO treatment does not impair mADSC viability and induces MGO-adduct accumulation. hREC migration is reduced in response to both MGO-treated mADSCs and conditioned media from MGO-treated mADSCs, compared to untreated cells. This is associated with an increase of SA-βGal activity, SASP factor release and p53 and p21 expression, together with a VEGF- and PDGF-reduced release from MGO-treated mADSCs and a reduced p38-MAPK activation in hRECs. The MGO-induced impairment of mADSC function is reverted by senolytics. In conclusion, MGO impairs mADSCs’ pro-angiogenic function through the induction of a senescent phenotype, associated with the reduced secretion of growth factors crucial for hREC migration.
Functional Characterization of Lysophospholipids by Proteomic and Lipidomic Analysis of Fibroblast-like Synoviocytes
Authors: Timm Thomas , Hild Christiane , Liebisch Gerhard , Rickert Markus , Lochnit Guenter , Steinmeyer Juergen
Published: June 2023

Synovial fluid (SF) from human knee joints with osteoarthritis (OA) has elevated levels of lysophosphatidylcholine (LPC) species, but their functional role is not well understood. This in vitro study was designed to test the hypothesis that various LPCs found elevated in OA SF and their metabolites, lysophosphatidic acids (LPAs), modulate the abundance of proteins and phospholipids (PLs) in human fibroblast-like synoviocytes (FLSs), with even minute chemical variations in lysophospholipids determining the extent of regulation. Cultured FLSs (n = 5–7) were treated with one of the LPC species, LPA species, IL-1β, or a vehicle. Tandem mass tag peptide labeling coupled with LC-MS/MS/MS was performed to quantify proteins. The expression of mRNA from regulated proteins was analyzed using RT-PCR. PL synthesis was determined via ESI-MS/MS, and the release of radiolabeled PLs was determined by means of liquid scintillation counting. In total, 3960 proteins were quantified using multiplexed MS, of which 119, 8, and 3 were significantly and reproducibly regulated by IL-1β, LPC 16:0, and LPC 18:0, respectively. LPC 16:0 significantly inhibited the release of PLs and the synthesis of phosphatidylcholine, LPC, and sphingomyelin. Neither LPC metabolite—LPA 16:0 nor LPA 18:0—had any reproducible effect on the levels of each protein. In conclusion, small chemical variations in LPC species can result in the significantly altered expression and secretion of proteins and PLs from FLSs. IL-1β influenced all proteins that were reproducibly regulated by LPC 16:0. LPC species are likely to modulate FLS protein expression only in more advanced OA stages with low IL-1β levels. None of the eight proteins being significantly regulated by LPC 16:0 have been previously reported in OA. However, our in vitro findings show that the CD81 antigen, calumenin, and B4E2C1 are promising candidates for further study, focusing in particular on their potential ability to modulate inflammatory and catabolic mechanisms.
Fiber-Reinforced Clay: An Exploratory Study on Automated Thread Insertion for Enhanced Structural Integrity in LDM
Authors: Yang Hui-Qin , Klug Christina , Schmitz Thomas H.
Published: June 2023

This exploratory study examines the potential of combining clay and natural fiber material in liquid deposition modeling (LDM) to enhance the structural integrity of the soft-bodied print during the additive manufacturing (AM) process. For this purpose, a custom extruder module and a support structure have been developed as novel additions to the delta 3D printer that allows for automated fiber thread insertion into the deposit clay body and stabilize the 3D print during drying. This study explores material compatibility and durability in the liquid state and the material strength of the sintered ceramic body after pyrolysis of the natural fibers. The findings demonstrate the feasibility of an automated process for thread insertion and tensioning control to stabilize and control the 3D print until drying and showcase the versatile design possibilities of this method. The study may serve as a baseline for future research on fiber-reinforced clay printing in the construction industry and related disciplines.
Use of Pulse Oximetry during Resuscitation of 230 Newborns—A Video Analysis
Authors: Kolstad Vilde , Pike Hanne , Eilevstjønn Joar , Buskov Frederikke , Ersdal Hege , Rettedal Siren
Published: June 2023

Background: European guidelines recommend the use of pulse oximetry (PO) during newborn resuscitation, especially when there is a need for positive pressure ventilation or supplemental oxygen. The objective was to evaluate (i) to what extent PO was used, (ii) the time and resources spent on the application of PO, and (iii) the proportion of time with a useful PO signal during newborn resuscitation. Methods: A prospective observational study was conducted at Stavanger University Hospital, Norway, between 6 June 2019 and 16 November 2021. Newborn resuscitations were video recorded, and the use of PO during the first ten minutes of resuscitation was recorded and analysed. Results: Of 7466 enrolled newborns, 289 (3.9%) received ventilation at birth. The resuscitation was captured on video in 230 cases, and these newborns were included in the analysis. PO was applied in 222 of 230 (97%) newborns, median (quartiles) 60 (24, 58) seconds after placement on the resuscitation table. The proportion of time used on application and adjustments of PO during ongoing ventilation and during the first ten minutes on the resuscitation table was 30% and 17%, respectively. Median two healthcare providers were involved in the PO application. Video of the PO monitor signal was available in 118 (53%) of the 222 newborns. The proportion of time with a useful PO signal during ventilation and during the first ten minutes on the resuscitation table was 5% and 35%, respectively. Conclusion: In total, 97% of resuscitated newborns had PO applied, in line with resuscitation guidelines. However, the application of PO was time-consuming, and a PO signal was only obtained 5% of the time during positive pressure ventilation.
The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review
Authors: Gunes-Bayir Ayse , Mendes Beyza , Dadak Agnes
Published: June 2023

Genetic and environmental factors including lifestyle are thought to play a key role in the pathophysiology of rheumatoid arthritis (RA). There is evidence that diet can enhance the inflammatory response in genetically predisposed individuals. On the other hand, certain types of diets can alleviate RA symptoms due to their anti-inflammatory and antioxidant activities. Also, natural compounds with potential effectiveness in RA management belong to different chemical classes such as flavonoids, polyphenols, carotenoids, and alkaloids with their antioxidant characteristics as well as probiotics. The nutritional approaches to prevent or extenuate the disease progress were examined in this narrative review which was conducted using the PubMed, ScienceDirect and Google Scholar databases and conforms to the Scale for the Assessment of Narrative Review Articles (SANRA) guidelines. Mediterranean and vegan diets equally have been shown to exhibit positive effects on RA as the consumption of dietary fiber, antioxidants and anti-inflammatory compounds from fruits, vegetables, grains, nuts, and seeds are high. Whereas Mediterranean diet additionally includes beneficial nutrients of animal origin such as omega-3 polyunsaturated fatty acids from fish and seafood, patients on vegan diet need to be monitored closely for intake of all critical nutrients. Certain calorie restrictions and intermittent fasting diets have been shown to benefit RA patients although there is an obvious need for further studies to establish solid evidence-based recommendations and guidelines. The research data available strongly suggest that dietary approaches with anti-inflammatory properties may help delay the onset of RA and/or improve symptoms and thus nutrition should be routinely addressed to facilitate management of the disease.
Optimization of Crystalline Diamond Coating Structure Architecture for Improving Adhesion and Cutting Performance in Milling with Cemented Carbide Inserts
Authors: Skordaris Georgios , Bouzakis Konstantinos-Dionysios , Bouzakis Antonios , Tsakalidis Dimitrios , Boumpakis Apostolos , Kompogiannis Spyridon , Bouzakis Emmanouil , Lemmer Oliver , Kölker Werner , Woda Michael
Published: June 2023

The adhesion, structure architecture, and residual stresses of crystalline diamond coatings (CDCs) on cemented carbide inserts are the factors that significantly affect tool life. The influence of these factors on cutting performance cannot be investigated separately since interactions among them exist. The paper elucidates such dependencies to optimize the CDC architecture and improve cutting performance. In this context, diamond coatings possessing different architectures were deposited on cemented carbide tools. The fatigue endurance and the milling performance of the coated tools were investigated using impact and milling tests, respectively. The residual stresses in the film structures were determined through impact tests and appropriate (Finite Element Analysis) FEA evaluation of the corresponding results. According to the obtained results, the application of a bottom micro-structured CDC prior to the deposition of an upper nanolayered one with inferior thickness improves the coated tools’ cutting performance. An optimum coating architecture is associated with a thickness ratio between the micro-structured bonding to the upper nanolayered CDCs of 2/1. Hereupon, the augmentation of coated tool life via the application of an optimum diamond coating architecture compensates for the high tool cost and improves milling productivity. The latter is further enhanced as the number of tool replacements decreases.
Active Ingredients and Natural Raw Materials Used in Foot Care in Diabetic Patients—A Literature Review
Authors: Krawiec Aleksandra , Czerwińska-Ledwig Olga , Kita Bartłomiej , Piotrowska Anna
Published: June 2023

Diabetic foot syndrome is the leading cause of limb loss due to non-healing ulcers. Repeated injuries, abnormal foot loads, and ischemia lead to ulcers. Poor shoe selection and inadequate care worsen the situation. Lack of patient education contributes to bacterial infections, tissue necrosis, and amputation. Vigilant observation and regular care can reduce wound size and prevent new wounds. Cleansing, infection control, and pressure relief are crucial in diabetic foot treatment. In this review, the effect of selected active ingredients and natural raw materials used for topical application in the care of diabetic foot was analyzed. The main focus used was on ingredients of natural origin—research studies utilizing emollients, humectants, plant extracts, and animal-derived ingredients were discussed. In addition, research studies on the application of nanomaterials, ozone and stem cells are also discussed. The cosmetics industry and manufacturers of podiatric products play a vital role in diabetic care. They should prioritize proper formulation, optimal ingredient doses, and skin microbiome control. Educating diabetics and using cosmetic products with self-massage elements can reduce the risk of hard-to-heal ulcers.
Quantitative Analysis of the Geometrically Representative Volume Element of the Yellow River’s Granular Ice Microstructure during the Freezing Period
Authors: Deng Yu , Wang Juan , Zhou Jiao , Zhang Peng
Published: June 2023

As a naturally polycrystalline material, Yellow River ice exhibits complex mechanical properties that are closely related to its internal microstructure. To study the micromechanical properties of this ice, the geometrically representative volume element (RVE) and a method for determining it are proposed. By observing and quantifying trends in the microstructural characteristics of the granular ice, a micro-numerical model of Yellow River ice is established. Based on the calculations and analyses of randomness and similarity across model samples, the dimensions of a geometric RVE of granular ice in the Yellow River are quantitatively determined. The research shows that the geometric representation of Yellow River granular ice is 20–24 times larger than the average grain of Yellow River granular ice. These results provide a technique to accurately study, at a microscopic level, the relationship between the material properties of each phase and their macromechanical response. It also provides a theoretical basis for studying the fracture failure mechanism of Yellow River ice at multiple scales.
Effect of Nano-Y2O3 on the Microstructure and Properties of Fe-Cr-C-N-Al Surfacing Alloy
Authors: Ai Xingyu , Liu Zhengjun , Zou Zongxuan
Published: June 2023

In this paper, Fe-Cr-C-N-Al-Y wear-resistant surfacing alloy was prepared by open-arc surfacing with self-shielded flux-cored wire. The wear properties of the surfacing alloy were analyzed using an MLS-23 rubber wheel wet sand wear tester. The phase composition and microstructure of the surfacing alloy were analyzed using X-ray diffraction, scanning electron microscope, electron backscatter diffraction and transmission electron microscope; the strengthening mechanism and wear mechanism of the alloy were discussed. The results show that the microstructure of Fe-Cr-C-N-Al-Y surfacing alloy is composed of M + γ-Fe + M7C3 + AlN. When the content of nano-Y2O3 is 0.456 wt.%, the formability of the surfacing alloy is the best, and the wetting angle is the smallest, which is 50.8°; AlN and M7C3 precipitate the most, and the microstructure grain is the smallest. At this time, the hardness value of the surfacing alloy is up to 62.3 HRC, which is 11.8% higher than that of the unmodified surfacing alloy. The minimum wear weight loss is 0.125 g, and the wear resistance is increased by 41.86%. The wear mechanism of the surfacing alloy is mainly a plastic deformation mechanism, and the material removal processes are microcutting and furrow wear. This study provides theoretical guidance for refining primary carbides and improving the wear resistance of high chromium cast iron.
High-Temperature Piezoelectric Response and Thermal Stability of BiGaO3 Modified BiFeO3–BaTiO3 Lead-Free Piezoelectric Ceramics
Authors: Guan Shibo , Yang Huabin , Cheng Shuai , Tan Hua , Qiao Guanjun , Chen Qiaohong , Xu Jiwen , Yuan Linna , Wang Xueting , Yang Ling
Published: June 2023

BiGaO3 doped BiFeO3–BaTiO3 ceramics were prepared by the traditional solid-phase synthesis process. The phase analysis, microstructure, piezoelectric, ferroelectric, dielectric properties, and thermal stability of 0.7BiFeO3-(0.3 − x)BaTiO3-xBiGaO3 (Abbreviated as BF–BT-xBG) were investigated. The results show that the ceramics have rhombohedral (R) and tetragonal (T) structures. Particle dimensions gradually get bigger with the increase of BiGaO3 concentration, and dense ceramic grains were observed through SEM. Electrical properties of BF–BT-xBG are improved after adding a small amount of BiGaO3: piezoelectric constants d33 = 141 pC/N, electromechanical coupling coefficient kp = 0.314, mechanical Quality Factor Qm = 56.813, dielectric loss tanδ = 0.048, residual polarization intensity Pr = 18.3 µC/cm2, Curie temperature Tc = 485.2 °C, depolarization temperature Td = 465 °C for x = 0.003. The “temperature-piezoelectric performance” curve under in situ d33 indicates that piezoelectric properties d33 increase rapidly with increasing temperature. Remarkably, the piezoelectric response d33 reaches a maximum of 466 pC/N at a temperature T = 340 °C, and afterward, reduces gradually to zero with increasing temperature until 450 °C.
Transition from Screw-Type to Edge-Type Misfit Dislocations at InGaN/GaN Heterointerfaces
Authors: Li Quantong , Minj Albert , Ling Yunzhi , Wang Changan , He Siliang , Ge Xiaoming , He Chenguang , Guo Chan , Wang Jiantai , Bao Yuan , Liu Zhuming , Ruterana Pierre
Published: June 2023

We have investigated the interface dislocations in InxGa1−xN/GaN heterostructures (0 ≤ x ≤ 0.20) using diffraction contrast analysis in a transmission electron microscope. The results indicate that the structural properties of interface dislocations depend on the indium composition. For lower indium composition (up to x = 0.09), we observed that the screw-type dislocations and dislocation half-loops occurred at the interface, even though the former do not contribute toward elastic relaxation of the misfit strain in the InGaN layer. With the increase in indium composition (0.13 ≤ x ≤ 0.17), in addition to the network of screw-type dislocations, edge-type misfit dislocations were generated, with their density gradually increasing. For higher indium composition (0.18 ≤ x ≤ 0.20), all of the interface dislocations are transformed into a network of straight misfit dislocations along the <10–10> direction, leading to partial relaxation of the InGaN epilayer. The presence of dislocation half-loops may be explained by a slip on basal plane; formation of edge-type misfit dislocations are attributed to punch-out mechanism.
Dy–Al–Si System: Experimental Study of the Liquid–Solid Phase Equilibria in the Al-Rich Corner
Authors: Cardinale Anna Maria , Parodi Nadia
Published: June 2023

The Dy–Al–Si ternary system has been experimentally studied, as the effect of the dysprosium addition on the constitution and topology of the liquidus surface, focusing on the (Al) rich part. The system has been investigated in a composition range of up to about 58 at% silicon. The alloys constitution and the liquidus surface projection have been determined by means of scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDXS), X-ray powder diffraction (XRPD), and differential thermal analysis (DTA). This work is part of a research framework on the properties and solid–liquid phase equilibria of the R Al–Si (R: rare earth) systems. These data, along with the ternary systems isothermal section, are needed to outline the design, plan, and development of new Al–Si-based alloys. In the Dy–Al–Si system, four primary crystallization fields have been experimentally detected: (Si), DyAlxSi(2−x) (orthorhombic form), Dy2Al3Si2 (Τ2), and DyAl(3−x)Six. The following three invariant equilibria have been identified: at 566 °C the ternary eutectic L ⇆ DyAl2Si2 + (Al) + (Si), at 630 °C the U1 L+ DyAl3 ⇆ Dy2Al3Si2 + (Al), and at 562 °C the U2: L+ Dy2Al3Si2 ⇆ DyAl2Si2 +(Al) reactions. A comparison with other known R Al–Si systems has been conducted.
Backyards Are a Way to Promote Environmental Justice and Biodiversity Conservation in Brazilian Cities
Authors: Lima Gedeone Ferreira , Correa Santos Jeater Waldemar Maciel , Albertin Ricardo Massulo , Martínez-Miranzo Beatriz , Souza Franco L. , Angeoletto Fabio
Published: June 2023

Brazilian cities feature quite unequal neighborhoods. Middle-class neighborhoods have better infrastructure than those inhabited by low-income families. These inequalities are not limited to social and economic scopes; they also reach the environmental one. Tree cover in these neighborhoods is often correlated to residents’ socioeconomic status. Injustice in access to trees deprives Brazilians of their ecosystem services. Furthermore, the scarcity of tree cover in the poorest neighborhoods means less support for biodiversity. Thus, backyards can be planned to form vegetation patches capable of providing urban populations with access to green areas, as well as working as wildlife habitats.
A Comprehensive Review of Recent Advances in Artificial Intelligence for Dentistry E-Health
Authors: Shafi Imran , Fatima Anum , Afzal Hammad , Díez Isabel de la Torre , Lipari Vivian , Breñosa Jose , Ashraf Imran
Published: June 2023

Artificial intelligence has made substantial progress in medicine. Automated dental imaging interpretation is one of the most prolific areas of research using AI. X-ray and infrared imaging systems have enabled dental clinicians to identify dental diseases since the 1950s. However, the manual process of dental disease assessment is tedious and error-prone when diagnosed by inexperienced dentists. Thus, researchers have employed different advanced computer vision techniques, and machine- and deep-learning models for dental disease diagnoses using X-ray and near-infrared imagery. Despite the notable development of AI in dentistry, certain factors affect the performance of the proposed approaches, including limited data availability, imbalanced classes, and lack of transparency and interpretability. Hence, it is of utmost importance for the research community to formulate suitable approaches, considering the existing challenges and leveraging findings from the existing studies. Based on an extensive literature review, this survey provides a brief overview of X-ray and near-infrared imaging systems. Additionally, a comprehensive insight into challenges faced by researchers in the dental domain has been brought forth in this survey. The article further offers an amalgamative assessment of both performances and methods evaluated on public benchmarks and concludes with ethical considerations and future research avenues.
Achalasia Subtype Differences Based on Respiratory Symptoms and Radiographic Findings
Authors: Jankovic Jelena , Milenkovic Branislava , Skrobic Ognjan , Ivanovic Nenad , Djurdjevic Natasa , Buha Ivana , Jandric Aleksandar , Colic Nikola , Milin-Lazovic Jelena
Published: June 2023

Three subtypes of achalasia have been defined using esophageal manometry. Several studies have reported that symptoms are experienced differently among men and women, regardless of subtype. All subtypes could have some impact on the appearance of respiratory symptoms and lung complications due to compression of the trachea or aspiration of undigested food. The aim of this research was to analyze the differences in respiratory symptoms and radiographic presentation of lung pathology depending on the diameter and achalasia types. One or more respiratory symptoms were reported in 48% of 114 patients, and all of them had two or more gastrointestinal symptoms. The symptom score (SS) is statistically significant for the prediction of subtype 1 (area under the curve = 0.318; p < 0.001, cut-off score of 6.5 had 95.2% sensitivity) and subtype 2 (area under the curve = 0.626; p = 0.020, cut-off score of 7.5 had 93.1% sensitivity). The most common type was subtype 2 (50.8%), and although only 14 patients had subtype 3, they had the largest esophageal diameter (mean 5.8 cm). The difference in esophageal diameter was significant between subtype 1 and 3 (p = 0.011), subtype 2 and subtype 3 (p = 0.011). Nine patients (6%) had mega-esophagus (four patients in type 1, three in type 2 and two in type 3). More than half of all patients (51.7%) had at least one parenchymal lung change on CT scan. Recurrent micro-aspirations led to changes in the structure of the airways and lung parenchyma such as ground glass (GGO) and nodular changes (12%) and fibrosis (14.5%), and they had higher esophageal diameters (p < 0.001). Patients with chronic lung CT changes had significantly higher esophageal diameter than with acute changes (p < 0.001). Awareness of the association of achalasia and lung disorders is important in early diagnosis and treatment. More than half (57.5%) of patients with achalasia had some clinical and/or structural pulmonary abnormalities. All three subtypes had similar respiratory symptoms, meaning they cannot be used to predict the subtype of achalasia; on the contrary, SS can predict the first two subtypes. A higher diameter of the esophagus is associated with chronic structural lung changes. Although unexpected, the pathological radiological findings and diameter were significantly different in subtype 3 patients, but those parameters cannot lead us to a specified subtype.
Overview of Long-Term Outcome in Adults with Systemic Right Ventricle and Transposition of the Great Arteries: A Review
Authors: Bevilacqua Francesca , Pasqualin Giulia , Ferrero Paolo , Micheletti Angelo , Negura Diana Gabriela , D’Aiello Angelo Fabio , Giamberti Alessandro , Chessa Massimo
Published: June 2023

The population of patients with a systemic right ventricle (sRV) in biventricular circulation includes those who have undergone an atrial switch operation for destro-transposition of the great arteries (d-TGA) and those with congenitally corrected transposition of the great arteries (ccTGA). Despite the life expectancy of these patients is significantly increased, the long-term prognosis remains suboptimal due to late complications such as heart failure, arrhythmias, and premature death. These patients, therefore, need a close follow-up to early identify predictive factors of adverse outcomes and to implement all preventive therapeutic strategies. This review analyzes the late complications of adult patients with an sRV and TGA and clarifies which are risk factors for adverse prognosis and which are the therapeutic strategies that improve the long-term outcomes. For prognostic purposes, it is necessary to monitor sRV size and function, the tricuspid valve regurgitation, the functional class, the occurrence of syncope, the QRS duration, N-terminal pro B-type natriuretic peptide levels, and the development of arrhythmias. Furthermore, pregnancy should be discouraged in women with risk factors. Tricuspid valve replacement/repair, biventricular pacing, and implantable cardioverter defibrillator are the most important therapeutic strategies that have been shown, when used correctly, to improve long-term outcomes.
A Graph-Space Optimal Transport Approach Based on Kaniadakis κ-Gaussian Distribution for Inverse Problems Related to Wave Propagation
Authors: da Silva Sérgio Luiz E. F. , de Araújo João M. , de la Barra Erick , Corso Gilberto
Published: June 2023

Data-centric inverse problems are a process of inferring physical attributes from indirect measurements. Full-waveform inversion (FWI) is a non-linear inverse problem that attempts to obtain a quantitative physical model by comparing the wave equation solution with observed data, optimizing an objective function. However, the FWI is strenuously dependent on a robust objective function, especially for dealing with cycle-skipping issues and non-Gaussian noises in the dataset. In this work, we present an objective function based on the Kaniadakis κ-Gaussian distribution and the optimal transport (OT) theory to mitigate non-Gaussian noise effects and phase ambiguity concerns that cause cycle skipping. We construct the κ-objective function using the probabilistic maximum likelihood procedure and include it within a well-posed version of the original OT formulation, known as the Kantorovich–Rubinstein metric. We represent the data in the graph space to satisfy the probability axioms required by the Kantorovich–Rubinstein framework. We call our proposal the κ-Graph-Space Optimal Transport FWI (κ-GSOT-FWI). The results suggest that the κ-GSOT-FWI is an effective procedure to circumvent the effects of non-Gaussian noise and cycle-skipping problems. They also show that the Kaniadakis κ-statistics significantly improve the FWI objective function convergence, resulting in higher-resolution models than classical techniques, especially when κ=0.6.
Educational Needs for Coping with Clinical Uncertainty in Physiotherapy
Authors: Infante Guedes Aday , Quintana Montesdeoca María del Pino , Etopa Bitata María Del Pilar
Published: June 2023

The physiotherapist inevitably experiences clinical uncertainty, as they treat a wide variety of pathologies and, in some situations, will be the first professional contact. However, clinical uncertainty has yet to be sufficiently studied in physiotherapy and is not explicitly contemplated in physiotherapist training. This research aims to evaluate recent physiotherapy graduates’ tolerance to clinical uncertainty to determine their educational needs. A cross-sectional quantitative observational study was conducted in which the sample consisted of 31 recent graduates. They were given a self-developed questionnaire to assess “Tolerance to Uncertainty in Physiotherapy” (TUP). The results showed that the mean score obtained was 57.7 (6.49) points, with a minimum of 43 and a maximum of 69 points. The dimension “sources of uncertainty” scored the highest. The results revealed a profile of novice physiotherapists with a medium intolerance to uncertainty, nervous about unknown diagnoses. It is necessary to consider tolerance to uncertainty in the curricular programmes of physiotherapy degrees that can cover the needs described here.
Exploring the Lived Experiences of Middle Grades Teacher Candidates Engaging in Critical Consciousness to Inform Equity-Oriented and Responsive Teacher Education
Authors: Andrews Gayle , Leonard Susan Y.
Published: June 2023

To inform equity-oriented and responsive middle grades teacher education, the current article is a qualitative study of the lived experiences of middle grades teacher candidates enacting critical consciousness in their first semester in a two-year equity-oriented middle grades teacher preparation program. Equity-oriented and responsive middle grades teacher education is defined as professional learning for middle grades preservice and inservice teachers that advances their development of critical consciousness, develops their capacity, knowledge, and skills as culturally and developmentally responsive teachers of young adolescents, and attends to their cultural and historical locations, pedagogical needs, interests, and concerns. Using a phenomenological research tradition and theories of critical consciousness and culturally relevant pedagogies, researchers closely examined 20 participants’ narratives and annotated reflections on how they “read the world” as perceived through the lenses of their cultural and historical locations and their descriptions of their experiences with critical incidents of perceived injustice as documented in Justice Journals. Two major themes emerged in participants’ data regarding their lived experiences of engaging in critical consciousness: (1) noticing and commenting on systems of oppression and (2) describing responses and strategies in connection to instances and patterns of injustice. Within the theme of noticing and commenting on systems of oppression, three sub-themes included (a) gender socialization, (b) classism, and (c) racism. Within the theme of describing responses and strategies in connection to instances and patterns of injustice, analysis revealed four sub themes: (a) responding to discomfort, (b) critiquing/distancing, (c) stopping, and (d) feeling blessed. These themes and sub-themes represent teacher candidates’ lived experiences of engaging in critical consciousness, primarily focused on critical awareness, critical reflection, and critical analysis. Implications for developing equity-oriented and responsive middle grades teacher education are provided.