bluuebunny/crossref_metadata_2025 huggingface dataset:
Heilige Solisten und Klostergemeinschaften
Authors: von Lüpke Beatrice , Blum Daniela
Published: June 2023

The Legendary ‘The Lives of the Saints’ became a medieval bestseller soon after it was composed in the early 15th century. This success was due to its simple, standardised language and its theological programme aimed at promoting a collectively lived spiritality. However, different concepts of holiness or narrative elements such as exorbitantly cruel martyrdoms, the ascetic isolations or mystical excess challenged this homogeneity. The article shows that the redactor was very conscious of these elements and made an effort to even them out. In this way, the Legendary partially counteracts its sources by narrating against a self-sanctification of the human being. Thus, it corresponds to the ideas of the Dominican Observance by developing a kind of literary asceticism.
Financial Incentives for Whistleblowing
Authors: Hogic Nedim
Published: June 2023

This article examines the recent trends in whistleblowing regulation, analysing the issue of financial rewards as one of the key distinctions between the legislative solutions on the matter in the United States as compared to European jurisdictions. Using the lens of corruption theories, the article concludes that the usage of financial rewards increases the overall regulatory capacity of the state to reduce corruption and fraud and reduce the emerging, largely anonymous digital whistleblowing. The financial rewards are also, due to the peculiar nature of both corruption and whistleblowing, an adequate tool to help to quantify the effects of whistleblowing. The article argues that the introduction of financial rewards should not be viewed as dependent on the differences in the legal traditions or culture but on the quality of the institutions and their ability to assess the reports of the whistleblowers. The article offers considerations concerning the conditions for the introduction of financial rewards.
Quasi-Biweekly Oscillation of Surface Sensible Heating over the Central-Eastern Tibetan Plateau and Its Relationship with Spring Rainfall in China
Authors: Hu Wenting , Duan Anmin , Wu Guoxiong , Mao Jiangyu , He Bian
Published: June 2023

This study examines the characteristics and phase evolution of the quasi-biweekly oscillation of surface sensible heating (SH) over the central-eastern Tibetan Plateau (CETP) during spring. The mechanism connecting CETP SH to spring rainfall in China on the quasi-biweekly time scale is further investigated. Results show that the dominant mode of quasi-biweekly CETP SH presents a monopole pattern, in which the peak leads the maximum of the quasi-biweekly rainfall in the middle and lower reaches of the Yangtze River (MLYR) and South China by approximately 5 and 7 days, respectively. As an upper-level Rossby wave train propagates eastward, an anomalous center of convergence moves to the CETP, which leads to a strong downdraft and reduced cloud cover. The resultant elevated shortwave radiation input and drier soil conditions are favorable for the CETP SH quasi-biweekly oscillation to enter a positive phase. When reaching its peak, the CETP SH efficiently heats the lower atmosphere, resulting in a local updraft. Due to the “SH-driven air pump” effect, abundant water vapor is transported from the oceans to China. A lower-layer southerly anomaly on the east side of the TP develops into an anomalous cyclonic circulation via the effect of topographic friction, which leads to the expansion of the positive potential vorticity anomaly and the maximum of the quasi-biweekly rainfall in the MLYR. Further southeastward propagation of the wave train leads to a shift in the rainfall anomaly center to South China. These findings suggest that the CETP monopole SH warming could be a good indicator for predicting intraseasonal variations in spring rainfall over China.
Burnout and Depression Among Sandwich Generation Caregivers: A Brief Report
Authors: Owsiany Montgomery T. , Fenstermacher Erika A. , Edelstein Barry A.
Published: June 2023

Twenty-nine percent of adults in the U.S. care for children, and 12% to 24.3% of those adults are multigenerational caregivers who also provide unpaid care for one or more adults. These adults are considered members of the “sandwich generation,” which is a term for multigenerational caregivers who provide care, financial support, and emotional support for both their children and parents. The present study characterized the sandwich generation and examined how sandwich generation caregivers differed from caregivers of children, caregivers of parents, and non-caregivers regarding burnout and depression. We found that sandwich generation caregivers and caregivers of parents reported significantly higher levels of informal caregiving burnout than caregivers of children. Compared to non-caregivers, all caregivers reported significantly higher levels of personal burnout. Burnout is higher in sandwich generation caregivers and those who care for parents than burnout among those who care only for children. Future studies should investigate additional variables that affect burnout.
Impact of coal evolution on formation of tight sandstone reservoirs: A case study in the Daniudi gas field, Ordos Basin, China
Authors: Liu Zihao , Wu Shenghe , Xu Zhenhua , Guo Rui , Liu Zhaowei , Liu Jiandang , Jia Chao , Xu Zhenyong
Published: June 2023

Tight sandstone gas in coal-bearing strata has become an important unconventional gas worldwide. This research aims at understanding the impacts of coal evolution on diagenesis and reservoir quality of sandstones by means of thin section, cathode luminescence (CL), scanning electron microscope (SEM), stable isotope analysis, and fluid inclusions. The results show that carbonate cement was the main type of cement developed in tight sandstone reservoirs, of which the carbonate ions were jointly provided by coal layers and reaction in adjacent mudstones. For sandstones close to coal layers, their carbonate ions were mainly controlled by coal evolution and there was various carbonate cement developed due to cations supplied by seawater and the intense dissolution of volcanic fragments and feldspars. Combined with coal thermal simulation and burial history, it implies that at different maturity stages of coal evolution, its impact on sandstone diagenesis was different. In the early stage, the main product was CO2, which caused the dissolution of early calcite and promoted intense compaction. In the mature stage, CO2 and other hydrocarbon gases were released, resulting in more dissolution and silica cementation. In the over-mature stage, the main product was methane, and CO2 that did not spill out preserved by forming carbonate cement. The coal evolution had a strong impact on the reservoir quality of sandstone with large grain sizes, but little effect on medium- and fine-grained sandstones. High porosity and low permeability reservoirs were usually formed in small conglomerates and coarse-grained sandstones away from coal layers. While low porosity and high permeability reservoirs were distributed close to coal layers. This study aids in understanding the formation mechanism of tight sandstone reservoirs in coal measures and provides theoretic support for further exploration.
The Labor Market Effect of South-to-South Migration: Evidence From the Venezuelan Crisis
Authors: Bonilla-Mejía Leonardo , Morales Leonardo F. , Hermida Didier , Flórez Luz A.
Published: June 2023

Following Venezuela's economic collapse, millions have fled the country. This article assesses the impact of the migration wave on the labor market outcomes of migrants and nonmigrants in Colombia, the major recipient of Venezuelan refugees and migrants. We address potential endogeneity problems in the estimation using a Bartik-type instrumental variable approach that exploits the regional variation of migrant networks and the timing and intensity of the Venezuelan economic crisis. While the migration flows increase unemployment in Colombia among migrants, they have no significant effect on nonmigrants’ unemployment. In fact, migration significantly reduces the labor participation of nonmigrants, offsetting its negative impact on employment. Employment losses among nonmigrants are mostly driven by self-employed workers and are consistently larger for female, young, and low-skill individuals. While returned migrants are overall unaffected, the negative impact of migration on migrants’ employment is mostly driven by international migrants. The massive arrival of migrants from Venezuela also affects internal migrants’ labor outcomes and changes the internal migration flows. These findings shed light on the labor market effects of migration flows between developing countries, a common phenomenon that has received relatively little attention in the specialized literature.
Ḥȝyšš, the Egyptian Hippokampos – Mythical Monster or Giant Oarfish?
Authors: Altmann-Wendling Victoria
Published: June 2023

A serpentine god is attested on over a dozen coffins and sarcophagi dating from the Third Intermediate Period onwards. In the earliest versions, it has the head of a horse, while in later ones it appears to be a purely mythical monster. The texts identify this deity as a protective god for the deceased. New pictorial and textual sources now allow a re-evaluation of previous explanations and a new proposal for interpretation.
School library censorship: Looking at the perspective of a school librarian association in Indonesia
Authors: Ayuningtyas Apriana Anggraeni , Heriyanto  , Irhandayaningsih Ana , Ganggi Roro Isyawati Permata
Published: June 2023

The information needs of students must be met by school libraries as resources for student learning with collections that support academic curricula and are suitable for learning activities. A collection that contains no sensitive or contentious material is one that is appropriate for students. In this study, censorship issues in school library collections are examined from the point of view of the Association of Indonesian School Librarians. The study found four topics connected to the Association’s perspective on censorship issues in school libraries based on staff interviews and thematic analysis: the root reasons for censorship; how censorship is implemented; how to become a competent librarian; and how urgent censorship is. Censorship is seldom reported, thus the Association does not view it as a pressing concern. It places greater emphasis on problems such as information literacy training and developing librarians’ competencies than censoring library collections. Hence, there is no national attention given to this subject.
Fighting Infodemics: Labels as Antidotes to Mis- and Disinformation?!
Authors: Mende Martin , Ubal Valentina O. , Cozac Marina , Vallen Beth , Berry Christopher
Published: June 2023

Infodemics—particularly the spread of misinformation and disinformation—are recognized as global threats to democracy, public health, and social cohesion. In this inquiry, the authors explore the marketing origins of infodemics to consider their content, genesis, and evolution. The authors conduct a systematic literature review to (1) synthesize the multidisciplinary research on mis-/disinformation (including marketing, public policy, psychology, information systems, computer science, and political science) and (2) develop a prescriptive and generative framework to stimulate research that helps counteract infodemics via disclosures and warning labels. The model considers the ways that label characteristics impact consumer response to mis-/disinformation, as well as how contextual and consumer factors may interact with aspects of labels to drive affective and cognitive responses, subsequently influencing attitudes, intentions, and behaviors related to labels, media content, and others. The influence of other consumers, as well as firm and policy interventions, on these outcomes is also considered. Thus, this inquiry presents a comprehensive model that bridges emerging literature across disciplines to present a holistic view of both infodemics and infodemic-related warning labels and proposes directions for future research and practical solutions related to the use of warning labels to counteract infodemics.
Determining acceptance and perceptions of chemotherapy dose banding in an ambulatory cancer centre
Authors: Ho Britney , Jo Lene Leow , Yap Peter , Lay Mui Poh , Chew Lita
Published: June 2023

Introduction

Despite the advantages of dose banding (DB) and numerous plans to adopt this practice, uptake of DB is still poor. As opinions of healthcare professionals were deemed essential in DB's acceptance, this study surveyed key stakeholders to determine the acceptance, facilitators, and barriers of DB in chemotherapy to improve its implementation.

Methods

A cross-sectional study at the National Cancer Centre Singapore, involving physicians, nurses, and pharmacy staff, was conducted in February 2022. The Theory of Planned Behaviour was adapted to design a survey questionnaire to obtain the acceptance, facilitators, and barriers of DB. Additional questions on maximum acceptable dose variance and essential criteria for selecting drugs for DB were included.

Results

A total of 93 participants responded, with a mean 9.75  ±  7.37 years of clinical experience. Less than half have heard of DB while few had prior experience. Drug cost was the top selection criteria for DB, followed by toxicity, therapeutic index, frequency of use and drug wastage. Acceptance rate of DB was 41.9%, with majority agreeing to use DB in various drugs but to determine patient suitability before usage. Being greatly affected by subjective norms, having a positive outlook for DB's impacts, and no effect on toxicity significantly influenced acceptance.

Conclusion

Prior to implementing DB at the institutional level, educational training addressing concerns over toxicity, and providing technological support can help improve acceptance. Future studies can involve patients’ perspectives and more institutions for greater diversity in opinions.
Purposive Action Under Conditions of Unpredictability: Lessons from Development Practice and Some Suggestions
Authors: Fforde Adam
Published: June 2023

The commentary addresses, with constructive suggestions, the tension between common beliefs that development knowledge is not predictive and the general requirement that it be used to support instrumental action (using devices such as the log frame or theories of change that embody ideas that X will lead to Y). I suggest that this tension is best resolved differently from much current practice, which tends to fudge the issue. I draw two central implications: first, that stakeholders to a possible development intervention decide formally, before proceeding, whether the context and knowledge of it suggest that it is wise to proceed instrumentally or not; second, that a positive aspect of the ‘fudge’ is that a significant share of development interventions, whilst organized according to instrumental principles (such as the log frame or theories of change), in fact lack suitable knowledge and so are, in reality, non-instrumental. In such contexts, development professionals, in fact, have well-developed but informal methods for acting ‘non-instrumentally’.
Impedance models for single and two degree of freedom linings with an improved data base and local non-linearity
Authors: Eversman Walter , Drouin Mary
Published: June 2023

Previously developed predictive models for impedance of single-degree-of-freedom and two-degree-of-freedom acoustic linings driven by a broad band acoustic source are reexamined. Two issues are addressed, the first being improvement of the conventional perforate face sheet impedance model. Data correlations based on flow bench measurements of steady flow pressure drop are reevaluated with emphasis on low flow velocity to improve the consistency of the prediction of linear resistance. In addition, for two-degree-of-freedom linings, face sheet mass reactance is modified to account for the presence of the septum. The second issue addresses the implication that for a non-linear lining, with impedance a function of the local sound pressure level, the installed performance of the lining depends on the local impedance, as opposed to impedance based on the source sound pressure level. This is investigated in the benchmarking of the impedance models by comparison of the acoustic transfer function predicted by a propagation code with the imbedded impedance model and transfer function measurements made in a grazing flow duct test facility. The propagation code is extended to make the non-linear behavior of the lining model dependent on the local acoustic spectrum, introducing an additional level of non-linearity and an iterative application of the propagation code. A principal conclusion is that with no grazing flow both the lining model and grazing flow duct transfer function measurements show a significant effect of local variation of the acoustic spectrum. With increasing grazing flow Mach number, this effect is reduced and effectively disappears at the highest Mach number. With increasing grazing flow Mach number the grazing flow contribution to face sheet resistance dominates and tends to mask the non-linear behavior of the component of resistance not related to grazing flow.
Technology acceptance of digital devices for home use: Qualitative results of a mixed methods study
Authors: Graeber Johanna , Warmerdam Elke , Aufenberg Svenja , Bull Christopher , Davies Kristen , Dixon Jan , Emmert Kirsten , Judd Claire , Maetzler Corina , Reilmann Ralf , Ng Wan-Fai , Macrae Victoria , Maetzler Walter , Kaduszkiewicz Hanna ,   on behalf of the IDEA-FAST consortium
Published: June 2023

Objective

Digital devices have demonstrated benefits to patients with chronic and neurodegenerative diseases. But when patients use medical devices in their homes, the technologies have to fit into their lives. We investigated the technology acceptance of seven digital devices for home use.

Methods

We conducted 60 semi-structured interviews with participants of a larger device study on their views on the acceptability of seven devices. Transcriptions were analysed using qualitative content analysis.

Results

Based on the unified theory of acceptance and use of technology, we evaluated effort, facilitating conditions, performance expectancy and social influence of each device. In the effort category, five themes emerged: (a) the hassle to use the device; (b) its usability; (c) comfort; (d) disturbance to daily life; and (e) problems during usage. Facilitating conditions consisted of five themes: (a) expectations regarding a device; (b) quality of the instructions; (c) insecurities with usage; (d) possibilities of optimization; and (e) possibilities to use the device longer. Regarding performance expectancy, we identified three themes: (a) insecurities with the performance of a device; (b) feedback; and (c) motivation for using a device. In the social influence category, three themes emerged: (a) reactions of peers; (b) concerns with the visibility of a device; and (c) concerns regarding data privacy.

Conclusions

We identify key factors that determine the acceptability of medical devices for home use from the participants’ perspective. These include low effort of use, minor disruptions to their daily lives and good support from the study team.
Emerging applications of extracellular vesicles in tumor therapy
Authors: Luo Hui , Jin Jing , Jin Jiajia , Lou Kecheng , He Hailan , Feng Shangzhi , Zeng Fei , Zou Junrong
Published: June 2023

Extracellular vesicles (EVs) have tremendous potential as nano/micron-sized drug delivery carriers.
Their physical, chemical and biological characteristics distinguish them as unique carriers with specific pharmacokinetic, circulating metabolic, and biodistribution patterns in the delivery of therapeutic cargoes. They are critical mediators in the pathology of many diseases, including inflammatory diseases, fibrosis, and cancer, but they are also essential mediators in immunomodulation, cancer treatment, infectious defense, and tissue repair. In this review, we emphasize recent advances in oncology therapy using macrophage EVs, mesenchymal stem cell EVs, milk EVs, and plant EVs, as well as the advantages of EVs as delivery platforms and their prospective clinical applications and use.
RETRACTED ARTICLE: Evaluation of the anticancer potential of CD44 targeted vincristine nanoformulation in prostate cancer xenograft model: a multi-dynamic approach for advanced pharmacokinetic evaluation
Authors: Naseer Faiza , Kousar Kousain , Abduh Maisa S. , Anjum Sadia , Ahmad Tahir
Published: June 2023

The in vivo anticancer potential of vincristine (VC) loaded, thiolated chitosan-based nanoformulation (NFs) with an outer hyaluronic acid (VC-loaded in TCs-HA) coating was studied in prostate cancer (PC) xenograft in the immunosuppressed rat model induced by PC3 cell lines. Our previous study has already reported the in vitro efficacy of the said NFs. The ADMET Predictor (TM) Cloud version 10.4.0.5, 64-bit, was used to simulate VC's physicochemical and pharmacokinetic parameters. The percentage of encapsulation efficiency of VC by direct and indirect methods was 81.5 and 90%, respectively. Plasma samples from healthy rats showed improved pharmacokinetic and bioavailability profiles of NFs compared to VC injection via HPLC. The haemolytic analysis of NFs showed two times lesser toxicity to red blood cells. Xenograft rats showed maximum tumour volume up to 235 ± 0.02 mm3 with increased body weight, and it was reduced by 56 ± 0.01 to 107.3 ± 0.03 mm3 during the whole treatment by NFs compared to pure VC. The histopathology of the NFs group showed less malignancy with angiogenesis and significantly less metastasis to the liver and kidney. ELISA showed high expression of apoptotic biomarkers, including Bax, cleaved Caspase 3, and cleaved PARP, while the expression of BCL2, Caspase 3, COX-II, NFκB, and TNF-α was reduced. Immunohistochemical analysis also revealed that post-NF administration, cytoplasmic expressions of TNF-α and COX-II were reduced, as were nuclear expressions of NFκB. Thus, the prepared chemotherapeutic NFs were a comparatively potent oncolytic agent, safe with lesser off-target toxicity, and had an improved pharmacokinetic and bioavailability profile.
Development, successes, and potential pitfalls of multidisciplinary chronic disease management clinics in a family health team: a qualitative study
Authors: Brooks Laura , Elliott Jacobi , Stolee Paul , Boscart Veronique Maria , Gimbel Sarah , Holisek Brittany , Randle Jason , Heckman George Albert
Published: June 2023

Background

The creation of Family Health Teams in Ontario was intended to reconfigure primary care services to better meet the needs of an aging population, an increasing proportion of which is affected by frailty and multimorbidity. However, evaluations of family health teams have yielded mixed results.

Methods

We conducted interviews with 22 health professionals affiliated or working with a well-established family health team in Southwest Ontario to understand how it approached the development of interprofessional chronic disease management programs, including successes and areas for improvement.

Results

Qualitative analysis of the transcripts identified two primary themes: [1] Interprofessional team building and [2] Inadvertent creation of silos. Within the first theme, two subthemes were identified: (a) collegial learning and (b) informal and electronic communication.

Conclusion

Emphasis on collegiality among professionals, rather than on more traditional hierarchical relationships and common workspaces, created opportunities for better informal communication and shared learning and hence better care for patients. However, formal communication and process structures are required to optimize the deployment, engagement, and professional development of clinical resources to better support chronic disease management and to avoid internal care fragmentation for more complex patients with clustered chronic conditions.
Identifying and validating the educational needs to develop a Celiac Self-Care System
Authors: Langarizadeh Mostafa , Rahmati Pakzad , Yousefpour Azari Shahram , Sarpourian Fatemeh , Sayadi Mohammad Javad , Langarizadeh Mohammad Hossein , Fatemi Aghda Seyed Ali
Published: June 2023

Background

Celiac disease is a major public health problem in many countries, including Iran. Considering the disease’s exponential spread throughout the world and its risk factors, identifying the educational priorities and minimum data required to control and treat the disease is of great significance.

Methods

The present study was conducted in two phases in 2022. In the first phase, a questionnaire was developed based on the information obtained from a review of the literature. Later, the questionnaire was administered to 12 pundits in the fields of nutrition (n = 5), internal medicine (n = 4), and gastroenterology (n = 3). As a result, the necessary and important educational content was determined for developing the Celiac Self-Care System.

Results

According to the experts’ viewpoints, the educational needs of patients were classified into nine categories of demographic information, clinical information, long-term complications, comorbidity, tests, medications, dietary recommendations, general recommendations, technical capabilities as well as 105 subcategories.

Conclusions

Due to the increased prevalence of Celiac disease and the lack of an established minimum set of data, determining the required educational information is of great importance at the national level. Such information could be useful in implementing educational health programs to raise the public level of awareness. In the field of education, such contents can be employed in planning new technology based on mobile phones (mobile health), preparing registries, and producing widely used content.
Bacterial shedding and serologic responses following an outbreak of Salmonella Typhi in an endemic cohort
Authors: Johnston Peter I. , Bogue Patrick , Chirambo Angeziwa Chunga , Mbewe Maurice , Prakash Reenesh , Kandoole-Kabwere Vanessa , Lester Rebecca , Darton Thomas , Baker Stephen , Gordon Melita A. , Meiring James E.
Published: June 2023

Background

Salmonella enterica serovar Typhi (Salmonella Typhi) is the cause of typhoid fever. Salmonella Typhi may be transmitted through shedding in the stool, which can continue after recovery from acute illness. Shedding is detected by culturing stool, which is challenging to co-ordinate at scale. We hypothesised that sero-surveillance would direct us to those shedding Salmonella Typhi in stool following a typhoid outbreak.

Methods

In 2016 a typhoid outbreak affected one in four residents of a Nursing School in Malosa, Malawi. The Department of Health asked for assistance to identify nursing students that might spread the outbreak to other health facilities. We measured IgG antibody titres against Vi capsular polysaccharide (anti-Vi IgG) and IgM / IgG antibodies against H:d flagellin (anti-H:d) three and six months after the outbreak. We selected participants in the highest and lowest deciles for anti-Vi IgG titre (measured at visit one) and obtained stool for Salmonella culture and PCR. All participants reported whether they had experienced fever persisting for three days or more during the outbreak (in keeping with the WHO definitions of ‘suspected typhoid’). We tested for salmonellae in the Nursing School environment.

Results

We obtained 320 paired serum samples from 407 residents. We cultured stool from 25 residents with high anti-Vi IgG titres and 24 residents with low titres. We did not recover Salmonella Typhi from stool; four stool samples yielded non-typhoidal salmonellae; one sample produced a positive PCR amplification for a Salmonella Typhi target. Median anti-Vi and anti-H:d IgG titres fell among participants who reported persistent fever. There was a smaller fall in anti-H:d IgG titres among participants who did not report persistent fever. Non-typhoidal salmonellae were identified in water sampled at source and from a kitchen tap.

Conclusion

High titres of anti-Vi IgG did not identify culture-confirmed shedding of Salmonella Typhi. There was a clear serologic signal of recent typhoid exposure in the cohort, represented by waning IgG antibody titres over time. The presence of non-typhoidal salmonellae in drinking water indicates sub-optimal sanitation. Developing methods to detect and treat shedding remains an important priority to complement typhoid conjugate vaccination in efforts to achieve typhoid elimination.
Comparison of IVF/ICSI outcomes in advanced reproductive age patients with polycystic ovary syndrome and advanced reproductive age normal controls: a retrospective cohort study
Authors: Zhang Xing , Lian Fang , Liu Danqi
Published: June 2023

Background

At present, there are few studies on whether there is reproductive advantage in advanced polycystic ovary syndrome (PCOS) patients, and the existing research results are also controversial. Some research results show that the reproductive window of advanced reproductive age patients with polycystic ovary syndrome is longer than that of the normal control group, and the clinical pregnancy rate and cumulative live birth rate of in vitro fertilization / intracytoplasmic sperm injection(IVF/ICSI)are higher. However, some studies have contradicted the results, and believed that the clinical pregnancy rate and cumulative live birth rate in IVF/ICSI in advanced PCOS patients and normal control groups were roughly similar. This retrospective study aimed to compare IVF/ICSI outcomes in advanced reproductive age patients with PCOS and in advanced reproductive age patients with tubal factor infertility alone.

Methods

A retrospective analysis was performed on advanced reproductive age (age ≥ 35 years) patients who received their first IVF/ICSI cycle between January 1, 2018 and December 31, 2020. This study was divided into two groups, one group was PCOS group, the other group was control group, namely tubal factor infertility group, a total of 312 patients and 462 cycles were enrolled. Compare the differences in outcomes such as cumulative live birth rate and clinical pregnancy rate between the two groups.

Results

In fresh embryo transfer cycles(ET), there was no statistically significant difference in live birth rate [19/62 (30.6%) vs. 34/117 (29.1%), P = 0.825] and clinical pregnancy rate [24/62 (38.7%) vs. 43/117 (36.8%), P = 0.797] between the PCOS and control groups.In the frozen embryo transfer (FET) cycle, the difference in cumulative live birth rate [63/217 (29.0%) vs. 14/66 (21.2%), P = 0.211] and clinical pregnancy rate [74/217 (34.1%) vs. 18/66 (27.3%), P = 0.300] were not statistically significant between the two groups.

Conclusions

The IVF/ICSI outcomes of advanced reproductive age patients with PCOS are similar to those of advanced reproductive age patients with tubal factor infertility alone, and the clinical pregnancy rate and live birth rate are roughly the same. Age is an important factor that affects clinical pregnancy rate. It is recommended that patients with PCOS complicated by infertility seek medical treatment as soon as possible to obtain better pregnancy outcomes.
Association between sleep quality and benign prostate hyperplasia among middle-aged and older men in India
Authors: Ma Kai , Dong Qiang
Published: June 2023

Background

The association between sleep quality and benign prostate hyperplasia (BPH) has rarely been studied. The aim of this study was to examine the relationship between sleep quality and BPH among middle-aged and older men in India.

Methods

This study used data from men over 45 years old in Wave 1 (2017–2018) of the Longitudinal Aging Study in India (LASI). Benign prostate hyperplasia was self-reported, and sleep symptoms were assessed using five questions modified from the Jenkins Sleep Scale. A total of 30,909 male participants were finally included. Multivariate logistic regression analysis, subgroup analysis, and interaction tests were performed.

Results

Total 453 (1.49%) men reported benign prostatic hyperplasia and have higher sleep quality score (9.25 ± 3.89 vs. 8.13 ± 3.46). The results revealed that the sleep quality score and risk of benign prostatic hyperplasia were significantly correlated after adjusting for all confounding factors (OR:1.057, 95% CI: 1.031–1.084, p < 0.001]. After dividing people into four groups based on the quartile of sleep quality scores, compared with the first quartile group, the third quartile group was 1.32 times, and the fourth quartile group was 1.615 times more likely to develop benign prostate hyperplasia. A significant interaction effect of alcohol consumption was observed. (p for interaction < 0.05).

Conclusion

Worse sleep quality was significantly associated with a higher incidence of benign prostatic hyperplasia among middle-aged and older Indian men. A further prospective study is needed to clarify this association and explore potential mechanisms.
Is VATS suitable for lung diseases with hemoptysis? Experience from a hemoptysis treatment center in China
Authors: Wang Bing , Yao Li , Sheng Jian , Liu Xiaoyu , Jiang Yuhui , Shen Lei , Xu Feng , Dai Xiyong
Published: June 2023

Background

Surgery is crucial in the treatment of the potentially fatal pulmonary hemoptysis condition. Currently, most patients with hemoptysis are treated by traditional open surgery (OS). To illustrate the effectiveness of video-assisted thoracic surgery (VATS) for hemoptysis, we developed a retrospective study of surgical interventions for lung disease with hemoptysis.

Methods

We collected and then analysed the data, including general information and post-operative outcomes, from 102 patients who underwent surgery for a variety of lung diseases with hemoptysis in our hospital between December 2018 and June 2022.

Results

Sixty three cases underwent VATS and 39 cases underwent OS. 76.5% of patients were male (78/102). Comorbidities with diabetes and hypertension were 16.7% (17/102) and 15.7% (16/102) respectively. The diagnoses based on postoperative pathology included aspergilloma in 63 cases (61.8%), tuberculosis in 38 cases (37.4%) and bronchiectasis in 1 case (0.8%). 8 patients underwent wedge resection, 12 patients underwent segmentectomy, 73 patients underwent lobectomy and 9 patients underwent pneumonectomy. There were 23 cases of postoperative complications, of which 7 (30.4%) were in the VATS group, significantly fewer than 16 (69.6%) in the OS group (p = 0.001). The OS procedure was identified as the only independent risk factor for postoperative complications. The median (IQR) of postoperative drainage volume in the first 24 h was 400 (195–665) ml, which was 250 (130–500) ml of the VATS group, significantly less than the 550 (460–820) ml of the OS group (p < 0.05). The median (IQR) of pain scores 24 h after surgery was 5 (4–9). The median (IQR) of postoperative drainage tube removal time was 9.5 (6–17) days for all patients, and it was 7 (5–14) days for the VATS group, which was less than 15 (9–20) days for the OS group.

Conclusion

VATS for patients with lung disease presenting with hemoptysis is an effective and safe option that may be preferred when the hemoptysis is uncomplicated and the patient's vital signs are stable.
Does the “Root Removal First” strategy prevent postoperative complications in the surgical removal of impacted mandibular third molars in the Pell and Gregory class C and horizontal position? — a randomized clinical trial
Authors: Wang Bing , Sun Rui , Li Tingting , Sun Yuqi , Zheng Linwei , Zhao Jihong
Published: June 2023

Objective

To evaluate the clinical outcomes of the “Root Removal First” strategy in the surgical removal of impacted mandibular third molar (IMTM) in the class C and horizontal position.

Materials and methods

A total of 274 cases were finally included in the statistics. The positions of IMTM in the horizontal position were confirmed by cone-beam computed tomography (CBCT). Cases were randomly divided into two groups: the “Root Removal First” strategy was applied in the new method (NM) group, and the conventional “Crown Removal First” strategy was executed in the traditional method (TM) group. The clinical information and relevant data upon follow-up were recorded.

Results

The duration of the surgical removal and the incidence rates of lower lip paresthesia in the NM group were significantly lower than those in the TM group. The degree of mobility of the adjacent mandibular second molar (M2) in the NM group was significantly lower than that in the TM group at 30 days and 3 months post-operation. The distal and buccal probing depth of the M2, as well as the exposed root length of M2 in the NM group, were significantly lower than those in the TM group 3 months post-operation.

Conclusions

The “Root Removal First” strategy can reduce the incidence rate of inferior alveolar nerve injury and periodontal complications of the M2 in the surgical removal of IMTM in class C and horizontal position with high efficiency.

Trial registration

ChiCTR2000040063.
Harnessing the power of collective intelligence in dentistry: a pilot study in Victoria, Australia
Authors: Ganhewa Mahen , Lau Alison , Lay Angela , Lee Min Jae , Liang Weiyu , Li Emmy , Li Xue , Khoo Lee Yen , Lee Su Min , Mariño Rodrigo , Cirillo Nicola
Published: June 2023

Background

In many dental settings, diagnosis and treatment planning is the responsibility of a single clinician, and this process is inevitably influenced by the clinician’s own heuristics and biases. Our aim was to test whether collective intelligence increases the accuracy of individual diagnoses and treatment plans, and whether such systems have potential to improve patient outcomes in a dental setting.

Methods

This pilot project was carried out to assess the feasibility of the protocol and appropriateness of the study design. We used a questionnaire survey and pre-post study design in which dental practitioners were involved in the diagnosis and treatment planning of two simulated cases. Participants were provided the opportunity to amend their original diagnosis/treatment decisions after viewing a consensus report made to simulate a collaborative setting.

Results

Around half (55%, n = 17) of the respondents worked in group private practices, however most practitioners (74%, n = 23) did not collaborate when planning treatment. Overall, the average practitioners’ self-confidence score in managing different dental disciplines was 7.22 (s.d. 2.20) on a 1–10 scale. Practitioners tended to change their mind after viewing the consensus response, particularly for the complex case compared to the simple case (61.5% vs 38.5%, respectively). Practitioners' confidence ratings were also significantly higher (p < 0.05) after viewing the consensus for complex case.

Conclusion

Our pilot study shows that collective intelligence in the form of peers’ opinion can lead to modifications in diagnosis and treatment planning by dentists. Our results lay the foundations for larger scale investigations on whether peer collaboration can improve diagnostic accuracy, treatment planning and, ultimately, oral health outcomes.
Long COVID: Costs for the German economy and health care and pension system
Authors: Gandjour Afschin
Published: June 2023

Background

Patients with acute COVID-19 can develop persistent symptoms (long/post COVID-19 syndrome). This study aimed to project the economic, health care, and pension costs due to long/post-COVID-19 syndrome with new onset in Germany in 2021.

Methods

Using secondary data, economic costs were calculated based on wage rates and the loss of gross value-added. Pension payments were determined based on the incidence, duration, and amount of disability pensions. Health care expenditure was calculated based on rehabilitation expenses.

Results

The analysis estimated a production loss of 3.4 billion euros. The gross value-added loss was calculated to be 5.7 billion euros. The estimated financial burden on the health care and pension systems due to SARS-CoV-2 infection was approximately 1.7 billion euros. Approximately 0.4 percent of employees are projected to be wholly or partially withdrawn from the labor market in the medium term due to long/post-COVID with new onset in 2021.

Conclusion

Costs of long/post-COVID-19 syndrome with new onset in 2021 are not negligible for the German economy and health care and pension systems but may still be manageable.
Assessing the sustainability and scalability of a diabetes eHealth innovation: a mixed-methods study
Authors: Sivakumar Arani , Pan Rachel Y. , Wang Angel , Choi Dorothy , Charif Ali Ben , Kastner Monika , Légaré France , Yu Catherine H.
Published: June 2023

Background

To date, little is known about the sustainability and scalability of MyDiabetesPlan, an eHealth innovation designed to facilitate shared decision-making within diabetes care. To avoid the possibility of its short-lived implementation and promote wider adoption so as to promote patient-centred diabetes care, it is critical to understand MyDiabetesPlan’s sustainability and scalability in order to ensure its long-term impact at a greater scale. We sought to identify the sustainability and scalability potential of MyDiabetesPlan and its limiting factors.

Methods

Using a concurrent triangulation mixed-methods approach, data were collected from 20 individuals involved in the development and implementation of MyDiabetesPlan. The National Health Services Sustainability Model (NHSSM) and the Innovation Scalability Self-administered Questionnaire (ISSaQ) were administered using a ‘think-aloud’ approach and subsequently, short semi-structured interviews were conducted. Mean aggregate scores and stakeholder-specific scores were generated for the NHSSM and ISSaQ, to quantitatively determine facilitating and limiting factors to sustainability and scalability. Content analysis occurred iteratively with qualitative data, to examine commonalities and differences with the quantitative findings.

Results

The top facilitating factor to sustaining MyDiabetesPlan was “Staff involvement and training to sustain the process.”, whereas the top limiting factors were: “Adaptability of Improved Process”, “Senior Leadership Engagement” and “Infrastructure for Sustainability”. The top three facilitating factors for scale-up were “Acceptability”, “Development with Theory” and “Consistency with Policy Directives.” Conversely, the top three limiting factors were “Financial and Human Resources”, “Achievable Adoption” and “Broad Reach”. Qualitative findings corroborated the limiting/facilitating factors identified.

Conclusions

Addressing staff involvement throughout the dynamic care contexts, and resource constraints impacting scale-up can enhance the sustainability and scalability of MyDiabetesPlan. As such, future plans will focus on garnering organizational leadership buy-in and support, which may address the resource constraints associated with sustainability and scalability and improve the capacity for adequate staff involvement. eHealth researchers will be able to prioritize these limiting factors from the outset of their tool development to purposefully optimize its sustainability and scalability performance.
Resilience, job satisfaction, intentions to leave nursing and quality of care among nurses during the COVID-19 pandemic – a questionnaire study
Authors: Sihvola Saija , Nurmeksela Anu , Mikkonen Santtu , Peltokoski Jaana , Kvist Tarja
Published: June 2023

Background

The COVID-19 pandemic has challenged nurses and healthcare systems globally and raised major concerns for nurses’ wellbeing and working conditions. This cross-sectional and correlational study design aims to describe nurses’ resilience, job satisfaction, intentions to leave and quality of care, and explain their relationships during the COVID-19 pandemic.

Methods

Data were collected from Registered Nurses (N = 437) in Finland through an electronic survey between February 2021 and June 2021. The questionnaire covered background characteristics (seven questions), resilience (four questions), job satisfaction (one question), intention to leave nursing (two questions), quality of care (one question), and requiring factors of the work (eight questions). The background variables and dependent variables were analyzed and presented using descriptive statistics. Structural equation modeling was used to explain dependent variables relationships. The study followed procedures recommended in the STROBE Statement for cross-sectional studies in efforts to maximize the quality of reporting results.

Results

The surveyed nurses evaluated their resilience by mean score 3.92, more nurses had considered leaving nursing during the pandemic (16%) than before (2%). Nurses´ mean score of requiring factors of the work was 2.56 and overall job satisfaction 5.8. Structural equation modeling revealed that resilience affected their job satisfaction, which also influenced the quality of care, that was rated moderate (7.46 out of 10). Structural equation modeling indices of goodness of fit were NFI = 0.988, RFI = 0.954, IFI = 0.992, TLI = 0.97, CFI = 0.992, and RMSEA = 0.064. No direct relationship was found between resilience and intention to leave nursing.

Conclusions

Good resilience promoted delivery of high-quality care by nurses during the pandemic and enhanced their job satisfaction, which reduced their intention to leave nursing. The results indicate that it is important to develop interventions that support nurses’ resilience.

Impact

The study highlights the importance of nurses’ resilience during the pandemic, while job satisfaction may decrease and requiring factors of the work increase. Given the number of nurses who consider leaving nursing, there are clear needs to develop effective strategies to maintain quality healthcare with resilient, committed nursing staff.
Chromosome-level genome assembly of Murraya paniculata sheds light on biosynthesis of floral volatiles
Authors: Yang Tianyu , Yin Xin , Kang Haotong , Yang Danni , Yang Xingyu , Yang Yunqiang , Yang Yongping
Published: June 2023

Background

Murraya paniculata (L.) Jack, commonly called orange jessamine in the family Rutaceae, is an important ornamental plant in tropical and subtropical regions which is famous for its strong fragrance. Although genome assemblies have been reported for many Rutaceae species, mainly in the genus Citrus, full genomic information has not been reported for M. paniculata, which is a prerequisite for in-depth genetic studies on Murraya and manipulation using genetic engineering techniques. Here, we report a high-quality chromosome-level genome assembly of M. paniculata and aim to provide insights on the molecular mechanisms of flower volatile biosynthesis.

Results

The genome assembly with a contig N50 of 18.25 Mb consists of 9 pseudomolecules and has a total length of 216.86 Mb. Phylogenetic analysis revealed that M. paniculata diverged from the common ancestor approximately 25 million years ago and has not undergone any species-specific whole genome duplication events. Genome structural annotation and comparative genomics analysis revealed that there are obvious differences in transposon contents among the genomes of M. paniculata and Citrus species, especially in the upstream regions of genes. Research on the flower volatiles of M. paniculata and C. maxima at three flowering stages revealed significant differences in volatile composition with the flowers of C. maxima lacking benzaldehyde and phenylacetaldehyde. Notably, there are transposons inserted in the upstream region of the phenylacetaldehyde synthase (PAAS) genes Cg1g029630 and Cg1g029640 in C. maxima, but not in the upstream region of three PAAS genes Me2G_2379, Me2G_2381, and Me2G_2382 in M. paniculata. Our results indicated that compared to the low expression levels of PAAS genes in C. maxima, the higher expression levels of the three PAAS genes in M. paniculata are the main factor affecting the phenylacetaldehyde biosynthesis and causing the content difference of phenylacetaldehyde. The phenylacetaldehyde synthetic activities of the enzymes encoded by M. paniculata PAAS genes were validated by in vitro analyses.

Conclusions

Our study provides useful genomic resources of M. paniculata for further research on Rutaceae plants, identifies new PAAS genes, and provides insights into how transposons contribute to variations in flower volatiles among Murraya and Citrus plants.