bluuebunny/crossref_metadata_2025 huggingface dataset:
Gastrointestinal bleeding as the first manifestation of Alagille syndrome - Case report
Authors: Campos Thayse , Baldanza Patrícia , Brandão Maria Angela
Published: March 2024

Introduction: The aim of this report is to describe a case of gastrointestinal bleeding that started at 1 month of age in a patient with Alagille Syndrome. Case report: Patient started recurrent gastrointestinal bleeding, leading to hypovolemic shock in the second month of life. During the investigation, cholestasis and incoagulable INR were evidenced. The facial stigmata, associated with the posterior embryotoxon in the ophthalmologic examination and transthoracic echocardiogram with stenosis of the pulmonary branches and patent foramen ovale, suggested the hypothesis of Alagille Syndrome, later confirmed by compatible liver biopsy and genetic testing with a mutation in the JAGGED1 gene. After administration of vitamin K, the patient evolved with normalization of the coagulogram, without new episodes of gastrointestinal bleeding. At follow-up, replacement of fat-soluble vitamins and treatment with ursodeoxycholic acid were initiated. Discussion: Reports in the literature describe bleeding episodes in patients with Alagille Syndrome, however, the main site of bleeding is the central nervous system. There is no description of bleeding in the gastrointestinal tract as the initial and neonatal manifestation of the syndrome. The case reported is an uncommon form of presentation and shows the importance of diagnostic suspicion in cases of neonatal cholestasis with gastrointestinal bleeding, allowing for adequate treatment and improved prognosis.
A General Three-Component Alkyl Petasis Boron-Mannich Reaction
Authors: Hu Chao , Tsien Jet , Chen Si-Jie , Kong May , Merchant Rohan , Qin Tian , Kanda Yuzuru
Published: March 2024

Aryl amines are one of the most common moieties in biologically active molecules, and approximately 37% of drug candidates contain aromatic amines. Recent advancements in medicinal chemistry, coined as “escaping from flatland”, have led to a greater focus on accessing highly functionalized C(sp3)-rich amines to improve the physiochemical and pharmacokinetic properties of compounds. This communication presents a modular and operationally straightforward three-component alkyl Petasis boron-Mannich (APBM) reaction that utilizes ubiquitous starting materials, including amines, aldehydes and alkyl boronates. Overcoming the long-standing synthetic hurdle of accomplishing the Petasis boron-Mannich reaction with alkyl boronate coupling partners was achieved via the formation of an electron donor-acceptor (EDA) complex and sequential radical-radical coupling. By adapting this transformation to high-throughput experimentation (HTE), it offers rapid access to an array of diverse C(sp3)-rich complex amines, amenable for facile drug candidate development.
Characterizing Discrete Binding Conformations of T4 L99A via Markov State Modeling
Authors: Zhang Chris , Osato Meghan , Mobley David
Published: March 2024

As a model system, the binding pocket of the L99A mutant of T4 lysozyme has been the subject of numerous computational free energy studies. However, some previous studies have failed to fully sample and account for the observed changes in the binding pocket of T4 L99A upon binding of a congeneric ligand series, limiting the accuracy of results. In this work, we establish definitions for the conformational states of the T4 L99A binding pocket based on the dynamics of the system rather than from experimental crystal structures. Using these definitions, we estimate the timescales for the transitions between states in this protein, which will have important implications for future binding studies in this system. We also discuss the need to develop enhanced sampling methods to generally account for significant changes in protein conformation due to relatively small ligand perturbations.
Boronic acid linked CPP for protein delivery
Authors: Ghosh Pritam
Published: March 2024

Studying functional protein delivery into live cells is important, ranging from fundamental research to therapeutics. Cell-penetrating peptides (CPPs) are known to deliver proteins with applauded efficacy and have gained importance for applications in protein therapeutics and exploring versatile cellular mechanisms. The primary aim of the work is to design a CPP as a tool/delivery vehicle for macromolecules, including proteins. In this work, boronic acid-linked cyclic deca arginine (cR10) is reported as an efficient CPP that exhibited threefold higher delivery of chemically synthesized ubiquitin (Ub) than pristine cR10-linked Ub, examined with live U2OS cells. As a futuristic plan, artificial intelligence machine learning-based rationale has been designed and proposed.
Interrogating endothelial barrier regulation by temporally resolved kinase network generation
Authors: Wei Ling , Dankwa Selasi , Vijayan Kamalakannan , Smith Joseph D , Kaushansky Alexis
Published: March 2024

Kinases are key players in endothelial barrier regulation, yet their temporal function and regulatory phosphosignaling networks are incompletely understood. We developed a novel methodology, Temporally REsolved KInase Network Generation (TREKING), which combines a 28-kinase inhibitor screen with machine learning and network reconstruction to build time-resolved, functional phosphosignaling networks. We demonstrated the utility of TREKING for identifying pathways mediating barrier integrity after activation by thrombin with or without TNF preconditioning in brain endothelial cells. TREKING predicted over 100 kinases involved in barrier regulation and discerned complex condition-specific pathways. For instance, the MAPK-activated protein kinase 2 (MAPKAPK2/MK2) had early barrier-weakening activity in both inflammatory conditions but late barrier-strengthening activity exclusively with thrombin alone. Using temporal Western blotting, we confirmed that MAPKAPK2/MK2 was differentially phosphorylated under the two inflammatory conditions. We further showed with lentivirus-mediated knockdown of MAPK14/p38α and drug targeting the MAPK14/p38α-MAPKAPK2/MK2 complex that a MAP3K20/ZAK-MAPK14/p38α axis controlled the late activation of MAPKAPK2/MK2 in the thrombin-alone condition. Beyond the MAPKAPK2/MK2 switch, TREKING predicts extensive interconnected networks that control endothelial barrier dynamics.
Investigating the Impact of Social Capital, Cross-Sector Collaboration, and Leadership on Social Innovation in Rural Social Enterprises
Authors: Kasumaningrum Yulistyne , Azis Yudi , Saefullah Kurniawan , Siregar Adiatma Y. M.
Published: March 2024

Objectives: This study aims to investigate empirical evidence regarding the relationship between social capital, cross-sector collaboration, leadership, and the development of social innovation in Indonesian villages with rural social enterprises, Badan Usaha Milik Desa (BUMDes). Methods/Analysis: The study employed a mixed approach, combining a quantitative survey, non-participative observation, and in-depth interviews. Data were collected from 280 BUMDes directors, communities, and village governments in the West Java province, Indonesia. The quantitative data were analyzed by structural equation modeling (SEM), and the hypotheses were tested against the variables investigated. The results were strengthened through in-depth interviews with five key informants. Findings: The findings reveal a significant positive effect of cross-sector collaboration and leadership on social innovation in BUMDes. However, social capital was found to have no significant effect on social innovation. Additionally, the study revealed a decline in community trust in rural Indonesia. Novelty/Improvements: This research provides empirical evidence on the influence of social capital, cross-sector collaboration, and leadership on social innovation in the context of rural social enterprises in developing countries. It makes a significant contribution to existing theory and has the potential to influence the development of rural social enterprise and social innovation, which has not been sufficiently researched to date. From an empirical perspective, this study provides evidence from West Java, Indonesia, regarding the relationship between these variables and indicators in the context of rural social enterprises in developing countries, where the sector is still at a developmental stage. Doi: 10.28991/HEF-2024-05-01-09 Full Text: PDF
Avaliação do Estresse em Idosos Submetidos à Cirurgia Eletiva Geral e Digestiva
Authors: Cavalcanti Sandra Lopes , Jucá Mario Jorge
Published: March 2024

Nosso objetivo foi avaliar o nível de estresse em idosos submetidos à cirurgia eletiva geral ou digestiva, no pré e pós-operatório de 64 pacientes com idade igual ou superior a 60 anos. Na coleta foi utilizada uma Ficha de Recolhimento de Dados e para a avaliação da perda da habilidade cognitiva o Teste do Desenho do Relógio e o Mini Exame do Estado Mental. Para avaliar o nível de estresse o Inventário de Estresse para Adultos de Lipp (2000) e a Escala de Estresse Percebido. Os resultados indicaram que, 65,6% eram do sexo feminino e 54,7% de analfabetos. Verificou-se a presença de estresse no pré-operatório (64,1%), e 59,7% no pós-operatório. Os pacientes idosos submetidos à cirurgia eletiva geral ou digestiva apresentaram-se estressados tanto no pré quanto no pós-operatório, salientando-se que o sexo feminino foi o que apresentou maior nível de estresse.
Estresse e Lócus de controle em adolescentes grávidas atendidas pela ESF em Maceió
Authors: De Goes Thyara Rúbia Vanderlei , Correia Divanise suruagy
Published: March 2024

Objetivando analisar a associação entre o estresse e o lócus de controle foram pesquisadas adolescentes grávidas em sete Unidades de Saúde da Família, Maceió, selecionadas por sorteio simples, sendo uma unidade de cada distrito sanitário. Estudo transversal analítico cujos dados foram coletados através de questionário socioeconômico, Escala multifatorial de Lócus de Controle e Inventário de Sintomas de Estresse. Os dados foram analisados no programa Epi Info versão 3.5, usando-se odds como medida estatística. Foram pesquisadas 39 adolescentes grávidas, de 10 a 19 anos, identificando-se que houve alto índice de estresse, apesar da maior predominância do lócus interno não houve associação estatística significativa entre este e o estresse. Os resultados mostram a necessidade de mais estudos e ações preventivas relacionadas ao tema.
Estresse e Lócus de Controle em Adolescentes Grávidas Atendidas pela ESF em Maceió
Authors: De Góes Thyara Rúbia Vanderlei , Correia Divanise Suruagy
Published: March 2024

Objetivando analisar a associação entre o estresse e o lócus de controle foram pesquisadas adolescentes grávidas em sete Unidades de Saúde da Família, Maceió, selecionadas por sorteio simples, sendo uma unidade de cada distrito sanitário. Estudo transversal analítico cujos dados foram coletados através de questionário socioeconômico, Escala multifatorial de Lócus de Controle e Inventário de Sintomas de Estresse. Os dados foram analisados no programa Epi Info versão 3.5, usando-se odds como medida estatística. Foram pesquisadas 39 adolescentes grávidas, de 10 a 19 anos, identificando-se que houve alto índice de estresse, apesar da maior predominância do lócus interno não houve associação estatística significativa entre este e o estresse. Os resultados mostram a necessidade de mais estudos e ações preventivas relacionadas ao tema.
Um Novo Espaço de Expressão e a Realização de um Sonho de Técnicos e Docentes do NUSP/FAMED/UFAL
Authors: Correia Divanise Suruagy
Published: March 2024

Editorial, 1(1)
Desfechos neonatais do consumo de cafeína na gestação: scoping review
Authors: Fernanda Santos Alcântara Bárbara , Bastos Dhayane Magalhães , Silva Letícia Henrique Leite da , Souza Natanael de , Figueiredo Elaine Virgínia Martins de Souza , Dias Renise Bastos Farias
Published: March 2024

Objetivo: mapear a produção de conhecimento atual sobre a exposição pré-natal à cafeína e seu impacto nos desfechos neonatais. Método: revisão de escopo, com estratégia de busca realizada em outubro de 2020 nas bases Science direct, SCOPUS, Pubmed Central e MEDLINE/PubMed via National Library of Medicine e CINAHL, ampliando-se às listas de referências das fontes utilizadas. A extração dos dados foi feita por dois revisores independentes e os dados analisados e sintetizados em forma de narrativa. Resultados: a amostra final foi composta por 07 estudos primários publicados entre 2016 e 2019, na língua inglesa, nível IV de evidência, abordando as características de consumo materno de cafeína, os métodos para identificação e as consequências neonatais associadas. Cerca de 50 % das mulheres selecionadas nos artigos primários dessa revisão relataram consumo médio de 130 mg/dia de cafeína por meio de café e chá, principalmente, além de consumo concomitante de tabaco e álcool. Houve identificação do consumo de cafeína ao risco de baixo peso ao nascer em 50 % dos estudos, assim como houve aumento da idade gestacional associado à cafeína de café e de intervenções neonatais associadas ao consumo de cafeína de chocolate; não foi identificado associação do consumo de cafeína com paralisia cerebral. Conclusão:Observou-se a correlação da exposição acentuada à cafeína durante a gravidez às consequências prejudiciais no neonato, com ênfase em alterações antropométricas, porém, ainda se fazem necessários mais estudos, visto que as informações não são absolutas.Palavras-chaves: Cafeína. Efeitos Tardios da Exposição Pré-Natal. Neonatologia.
Rastreamento para câncer de colo de útero: estudo descritivo
Authors: Barbosa Anderson Ferreira , Barbosa Nirliane Ribeiro , Pereira Luciana Xavier , Barbosa Salviane dos Santos , Rodrigues Lara Mykaelle Braga , Farias Karol Fireman de
Published: March 2024

Objetivo: Descrever a frequência de exames de colpocitologia oncótica no município de Arapiraca- AL, em 2019. Método: Estudo descritivo realizado por meio do acesso a plataforma do Departamento de Informática do Sistema Único de Saúde (DATASUS), com dados primários do Sistema de Informação do Câncer (SISCAN). Foram obtidos dados de mulheres de 9 anos até os 79 anos ou mais, do município de Arapiraca, sendo analisada a faixa etária, exames realizados anteriormente, motivos do exame e células atípicas escamosas. Resultados: Verificou-se a menor incidência de rastreamento para câncer de colo de útero entre mulheres de 24 anos abaixo, assim como em mulheres na senescência. A maioria 83,9%das pacientes que realizaram o Papanicolau em 2019 fizeram rastreamento tendo realizado citologia anterior e 80,90% dos exames foram realizados na faixa-etária preconizada, 12,40%, abaixo de 24 anos e 6,69% acima de 65 anos. Conclusão: São necessárias mais intervenções, detecção e melhorias no diagnóstico como medidas efetivas.
A divulgação científica universitária por meio de uma ação de extensão: contribuições do CInTec
Authors: Dias Renise Bastos Farias , Figueiredo Elaine Virgínia Martins de Souza
Published: March 2024

A divulgação científica está entre as funções das universidades e tem como objetivo garantir o acesso da população aos conhecimentos científicos e tecnológicos. Desta forma, o presente artigo tem como objetivo discutir o papel da universidade na divulgação científica e translação do conhecimento, por meio de uma ação de extensão. Trata-se de um relato narrativo sobre a divulgação científica ocorrida no Congresso de Inovação e Tecnologia em Diagnóstico Laboratorial do Agreste Alagoano (CInTec), ofertado desde 2018 através da parceria de professores, alunos e técnicos vinculados ao Laboratório de Biologia Molecular e Expressão Gênica da Universidade Federal de Alagoas, Campus Arapiraca, com profissionais de saúde, estabelecendo uma relação ensino e serviço construtiva. Em 2020 o III CInTec, oportunizou a divulgação e a disseminação científica, com a participação de quase 300 autores de trabalhos científicos oriundos de instituições públicas e privadas que publicaram suas produções, resultantes de estudos de revisão, relatos de experiências, pesquisas originais e epidemiológicas realizadas por docentes e discentes no contexto dos seus grupos de pesquisas, com ou sem financiamentos por órgãos de fomento, contribuindo para que a universidade cumprisse seu papel na divulgação científica.
Fake News: Combata esse vírus! Projeto Fake Não!
Authors: Souza Carlos Dornels Freire de , Yamashita Miyuki , Magalhaes Amanda Julia de Arruda , Ferreira Amanda Karine Barros , Sampaio Bruna Karolayne Oliveira , Silva Celso Marcos da , Feitoza Erielly Maria Bezerra Araújo , Soares Érika de Fátima Machado , Lima Flavia Ferreira do Nascimento Silva , Costa Laurisson Albuquerque da , Silva Louryanne de Castro , Santos Lucas Gomes , Machado Michael Ferreira , Santos Samilla Cristinny , Leal Thiago Cavalcanti , Santos Valdilene Canazart dos , Junior Wilmo Ernesto Francisco , Nobre Yasmin Vitoria Silva , Oliveira Nobre e Iara Terra de
Published: March 2024

A COVID-19, doença causada pelo vírus SARS-CoV-2, tem como característica a rápida transmissão. Desde seu relato no final de dezembro de 2019, em Wuhan, na China, a doença se alastrou pelos 5 continentes. Em 20 março de 2020, o governador de Alagoas decretou estado de calamidade pública no Estado de Alagoas atribuído à pandemia do COVID-19, suspendendo o funcionamento de vários estabelecimentos. Face ao exposto, a quantidade de conteúdos veiculados nas redes sociais acerca da pandemia contribui com a disseminação de notícias falsas. Essas notícias, uma vez espalhadas, dificultam a adesão às medidas de contenção do vírus orientadas pelas agências oficiais de saúde. Uma das consequências é o aumento do número de pessoas infectadas, levando à sobrecarga do sistema de saúde. Dessa maneira, o presente projeto busca minimizar os impactos da propagação de informações falsas a partir de debates das Fake News relacionadas à COVID-19. Neste boletim, vamos apresentar sete notícias falsas relacionadas com a COVID-19.
A detecção do Papiloma Vírus Humano (HPV) em colpocitologias oncóticas
Authors: Barbosa Salviane dos Santos , Barbosa Nirliane Ribeiro , Barbosa Anderson Ferreira , Rodrigues Lara Mykaelle Braga , Dias Renise Bastos Farias , Farias Karol Fireman de
Published: March 2024

Objetivo: Avaliar a detecção de HPV em colpocitologias oncóticas (CO) no município de Arapiraca – AL, na perspectiva de saúde pública. Método: Realizou-se um estudo de abordagem quantitativa, através de pesquisa no Sistema de Informações do Câncer (SISCAN), no período de 2015 a 2019, verificando-se como variáveis independentes o município que prestou serviço no estado de Alagoas, a faixa etária de mulheres que realizaram colpocitologia oncótica e a quantidade de exames que detectaram HPV; já como variável dependente, destacam-se exames por células atípicas escamosas. Resultados: Nos últimos cinco anos, 63.451 mulheres realizaram colpocitologia oncótica no município estudado. Observou-se maior frequência na faixa etária de 40 a 44 anos (12,08 %) e declínio a partir da faixa etária entre 45 a 49 anos, passando de 11,16 % a 0,28 % em mulheres acima de 79 anos. Com relação à investigação por células escamosas atípicas, a displasia de lesões de baixo grau (HPV e NIC I) foi identificada em 202 exames (0,32 %), sendo grande o percentual de exames com resultado ignorado (99,60 %). Percebeu-se pequena variação anual na detecção do HPV entre os anos estudados, sendo distribuída numa frequência similar (variando de 20,3 % a 23,76 %), com uma taxa ainda menor no ano de 2017 (13,37 %). Conclusão: O estudo contribui para ressaltar, no âmbito da saúde pública, a importância de orientar as mulheres quanto à realização do exame na triagem das lesões do colo uterino, sensibilizando-as frente ao combate à infecção pelo HPV.Palavras-Chave: Papiloma Vírus Humano; Diagnóstico; Saúde Pública; Saúde da Mulher; Colo Uterino.
Perspectivas y controversias de las nuevas biotecnologías. Apuntes sobre una tecnología del siglo XXI
Authors: Taguenca Belmonte Juan Antonio
Published: March 2024

No queremos dejar escapar la oportunidad que nos brinda esta introducción para dejar consignadas por escrito algunas de las consideraciones que nos han ocupado y preocupado durante la elaboración de este libro. El ser humano se enfrenta por primera vez a la posibilidad de crear vida recombinando la existente. Los viejos mitos en forma de animales mitológicos empiezan a ser posibles en la realidad; los sueños del aprendiz de mago de dominar las fuerzas naturales y convertirlas en aquello que se desea han iniciado su camino hacia el mundo que habitamos. La naturaleza “natural” convertida en social por el homo sapiens deja definitivamente de pertenecerse para pertenecernos, sus últimos secretos son publicados.
Diagnóstico participativo de las poblaciones indígenas del estado de Hidalgo
Authors: Vázquez Sandrín Germán
Published: March 2024

En México existe una gran diversidad de culturas correspondientes a sus distintos pueblos indígenas. En 2010 se reconocieron 68 agrupaciones lingüísticas así como 364 variantes lingüísticas y su distribución territorial extendida por casi la totalidad del país. Es lógico suponer que exista una gran variedad de configuraciones demográficas entre los indígenas y la evidencia empírica lo constata (Vázquez, 2013). Sin embargo, la categoría de población indígena es una generalidad que borra todas estas especificidades y arroja una homogeneidad falsa y distorsionada. Es por ello que esta categoría de identificación indígena es empleada como un instrumento de etnocidio estadístico.
ANALISIS EFISIENSI EKONOMI DAN PENDAPATAN USAHA TAMBAK IKAN BANDENG DI KABUPATEN BIMA
Authors: Sa'diyah Halimatus , Marsum Nur Qomariah , Suparmin Suparmin
Published: March 2024

Ikan Bandeng Kabupaten Bima memiliki cita rasa khas, tidak berbau lumpur karena dibudidayakan secara organik hanya menggunakan pakan alami berupa plankton yang ditumbuhkan pada areal tambak tanpa pakan butiran (pelet). Minimnya penggunaan input ini di satu sisi dapat menghemat biaya, namun di sisi lain produksi tidak dapat maksimal. Dalam kondisi seperti ini evaluasi terhadap efisiensi penggunaan factor produksi sangat penting untuk dilakukan agar keuntungan yang dicapai dapat maksimum. Secara umum penelitian bertujuan untuk mengevaluasi tingkat penggunaan input yang efisien. Secara spesifik penelitian ini bertujuan untuk (1). Mengestimasi fungsi produksi ikan bandeng pada usaha tambak Kabupaten Bima. (2). Menganalisis tingkat efisiensi penggunaan input produksi pada usaha tambak ikan bandeng Kabupaten Bima, dan (3). Menganalisis pendapatan usaha tambak ikan bandeng Kabupaten Bima. Penelitian dilaksanakan di Kecamatan Woha yang dipilih secara sengaja dengan alasan Kecamatan Woha memiliki luas areal tambak bandeng terbesar. 60 petambak dipilih secara proporsional random sampling dari 5 desa yaitu Desa Talabiu, Dadibou, Donggobolo, Penapali dan Pandai. Bentuk Fungsi Produksi Cobb-Douglass digunakan untuk mengestimasi fungsi produksi, tingkat efisiensi diukur dengan persamaan Nilai Produk Marginal sama dengan Biaya Korbanan marginal, dan Pendapatan diukur dengan mengurangkan Penerimaan Total dengan Biaya Total. Hasil Penelitian menunjukkan bahwa analisis tingkat efisiensi menghasilkan bahwa Luas Lahan, Nener dan Pupuk penggunaannya belum efisien sehingga penggunaannya perlu ditingkatkan, sedang Tenaga Kerja dan Obat obatan sudah melampaui tingkat efisiensinya sehingga perlu dikurangi. (3) Pendapatan rata-rata petani tambak pada usahatani ikan bandeng di Kecamatan Woha Kabupaten Bima pada satu musim tanam (4 bulan) sebesar Rp.30.493.818/LLG (1,5 ha) atau Rp.19.656.522/Ha
ANALISIS KOMPARASI KINERJA FINANSIAL PETANI MITRA DAN NON MITRA PADA USAHATANI TEMBAKAU VIRGINIA DI KABUPATEN LOMBOK TIMUR OF INDONESIA
Authors: Yakin Addinul , Rahmatin Rizqi Auliya’u
Published: March 2024

Tobacco is a strategic commodity with significant economic value and profitable cultivation for farmers. Establishing a business partnership is a viable approach for achieving this goal. The purpose of this study was to compare the financial performance of partner and non-partner farmers in East Lombok district tobacco cultivation. Profit, return on capital, net profit margin (NPM), and profitability are used to evaluate financial performance. All of the foregoing measures demonstrated that the financial performance of Virginia tobacco farmers who participated in the partnership program was significantly higher than that of farmers who did not participate. This is achievable due to the fact that farmer partnerships make it possible to gain knowledge and direction on optimal tobacco farming (good practices), so allowing farmers to increase their production and productivity. In addition, partner farmers have pricing certainty, allowing them to generate more earnings. As a result, tobacco growers and farmers of other commodities are encouraged to form mutually advantageous relationships with related businesses in order to increase their profitability
MODEL ARIMA BOX-JENKINS UNTUK MERAMALKAN JUMLAH KUNJUNGAN WISATAWAN MANCANEGARA DI KABUPATEN LOMBOK BARAT
Authors: Setiawan Rifani Nur Sindy , Kusuma Wirajaya , Primajati Gilang , Soraya Siti , Aziza Istin Fitriana
Published: March 2024

The development of tourism in West Lombok is supported by geographical conditions with scattered clusters of small islands (gili), tropical climate, and the cultural peculiarities of the Sasak tribe, so that it becomes an attraction in the development of global tourist destinations. West Lombok tourism development will be even more attractive with the establishment of the Mandalika National Tourism Development Strategic Area. West Lombok can play a role concurrently with this strategic policy momentum. Developing new growth centers based on the tourism sector in collaboration with other sectors and packaging the village's potential to become a thematic tourism village. Methods for predicting the number of tourist visits to West Lombok Regency are urgently needed to assist the district government in preparing appropriate facilities and infrastructure if there is a possibility of an increase in tourist visits. The method used in this study is the Box-Jenkins ARIMA method to predict the number of foreign tourist visits in West Lombok Regency. The data used in this study is secondary data sourced from the West Lombok Regency Tourism Office from January 2014 to December 2021. The results showed that the ARIMA model (2,1,2) is the most suitable model for predicting the number of foreign tourist visits to West Lombok Regency because this model produces the smallest Sum of Squared Errors (SSE) and Mean Squared Error (MSE) values compared to other models.
PERSEPSI MASYARAKAT TERHADAP PRODUK OLAHAN PUDING JAGUNG DESA KUTA BLANG KECAMATAN SAMA DUA KABUPATEN ACEH SELATAN
Authors: Mulki M. Dhuhiral , Handayani Sri
Published: March 2024

Kabupaten Aceh Selatan merupakan salah satu Kabupaten dari Provinsi Aceh yang memiliki lahan pertanian yang cukup luas. Mayoritas masyarakat daerah tersebut, memanfaatkan lahannya untuk menanami tanaman pangan guna memenuhi kebutuhan pangan. Jagung merupakan salah satu tanaman yang ditanam oleh sebahagian besar masyarakat di Kab. Aceh Selatan khususnya di Kecamatan Sama Dua Desa Kuta Blang. Biasanya jagung yang diproduksi oleh petani dijual kepada produsen yang menampung untuk dikirim kedaerah lain. Ketersedian jumlah jagung di Desa Kuta Blang saat ini akan lebih baik jika dapat dimanfaatkan oleh masyarakat untuk diolah menjadi produk bernilai jual. Namun, biasanya petani mengkonsumsi jagung sendiri dengan direbus atau dijadikan sayuran dan sebahagian lainnya menjadikan jagung sebagai pakan ternak. Tujuan penelitian ini adalah untuk mengetahui persepsi petani Desa Kuta Blang Kabupaten Aceh Selatan terhadap olahan puding jagung melalui 8 aspek kategori persepsi. Metode penelitian yang digunakan dalam penelitian ini adalah jenis kuantitatif deskriptif melalui penyebaran kuesioner lalu kemudian dihitung dan dianalisis. Analisa data penelitian mencakup hasil kuesioner yang disebarkan kepada responden mengenai persepsi petani tentang olahan puding jagung yang dinilai berdasarkan 8 aspek. Hasil penelitian menunjukkan bahwa terdapat 3 aspek berkategori “baik” dan terdapat pulal 4 aspek berkategori “cukup baik”.
UJI EFEKTIVITAS BEBERAPA TANAMAN OBAT TERHADAP REPELENSI SERANGGA HAMA PERUSAK BERAS PADI VARIETAS CILIWUNG DI GUDANG BERAS
Authors: Antaboga Krisna , Supeno Bambang , Haryanto Hery
Published: March 2024

The purpose of this study was to determine the effectiveness of some plant material as insect repellence agents for rice pests Ciliwung variety. The methods used are field experiments and specimen collection. The research was carried out in one of the rice warehouses in Kuripan District and the Plant Protection Laboratory, Faculty of Agriculture, University of Mataram. The experiment was designed with a Group Randomized Design (GRD) consisting of six treatments. These treatments are; P0 (control), P1 (betel leaf; Piper crocatum), P2 (fragrant pandan leaves; Pandanus amarylifolius), P3 (bay leaf; Syzigium polyanthum), P4 (kaffir lime leaves; Citrus hystrix), and P5 (garlic bulbs; Alium Sativum). The results showed that betel leaf, fragrant pandan leaf, bay leaf, and kaffir lime leaf were effective against the rejection of three insect pests found. Three families of rice-destroying pests were found in Ciliwung varieties, namely; Family Tenebrionidae, Family Curculionidae, and Family Pyralidae. The plant materials used (betel leaf, fragrant pandan leaf, bay leaf, kaffir lime leaf, and garlic bulb) have no real effect on the diversity, dominance, and richness of Ciliwung variety rice pest species
EVALUASI KINERJA HUTAN KEMASYARAKATAN GAPOKTAN ALAM LESTARI RESORT JANGKOK KESATUAN PENGELOLAAN HUTAN RINJANI BARAT
Authors: Ananda Siti Munawarah , Setiawan Budhy , Valentino Niechi
Published: March 2024

NTB Province is committed to implementing the Ministry of Environment and Forestry Regulation Number 9 of 2021 which states that there is a need to increase the economic activities of residents living around forests through social forestry schemes. The most popular social forestry scheme is HKm. The HKm scheme is of more interest to the people of NTB because it aims to improve the welfare of communities around the forest and its implementation can be carried out in protected and production forests. Based on the above problems, it is necessary to conduct research related to the evaluation of HKm management of Gapoktan Alam Lestari in order to find out the economic, ecological and social aspects regulatedinPerdirjen Perhutanan Sosial dan Kemitraan Lingkungan No.P.9/PSKL/PKPS/KUM.1/10/2019. Descriptive method was used in this research. A snowball sampling approach was used to determine respondents. Gapoktan Alam Lestari obtained a medium score (75%) in its evaluation.
PERKEMBANGAN KEMAMPUAN BERSWASEMBADA PANGAN KABUPATEN LOMBOK TENGAH
Authors: Ayu Candra , Wuryantoro Wuryantoro
Published: March 2024

Kabupaten Lombok Tengah merupakan salah satu sentra produksi pangan di Propinsi Nusa Tenggara Barat. Namun, kemampuan tersebut semakin berkurang dalam periode waktu sepuluh tahun terakhir yaitu dari tahun 2011sampai tahun 2020 akibat tingginya alih fungsi lahan untuk pembangunan ekonomi yang lajunya mencapai 11 % per tahun. Lahan yang dialih fungsikan tersebut pada umumnya merupakan lahan sawah irigasi yang digunakan untuk usahatani tanaman padi dan palawija. Penelitian ini bertujuan menganalisis perkembangan kemampuan berswasembada pangan Kabupaten Lombok Tengah selama periode tahun 2011-2020. Data yang digunakan adalah data sekunder, dengan teknik analisis data menggunakan rumus matematik dari konsep gabungan teori Odum, Christeiler, Ebenezer Howard dan Issard. Hasil penelitian menunjukkan bahwa kemampuan daya dukung lahan pertanian di Kabupaten Lombok Tengah untuk berswasembada pangan selama periode tahun 2011-2020 menurun dari berkemampuan sedang pada periode 2011-2019 menjadi berkemampuan rendah dengan nilai yang kurang dari 1 dan menjadi daerah defisit pangan. Hal ini akibat penurunan luas panen tanaman pangan seluas 2.656,26 ha/tahun dan penurunan produksi setara beras sebanyak 7.133.263,91 kg/tahun sedangkan luas lahan minimal per kapita meningkat seluas 0,00005 ha/tahun. Jika tidak ada regulasi yang melindungi lahan pertanian tanaman pangan, maka Kabupaten Lombok Tengah terancam menjadi daerah defisit pangan dan menurunkan kemampuan Propinsi NTB sebagai salah satu dari sembilan propinsi yang menjadi sentra produksi pangan di Indonesia.
ANALISIS KELAYAKAN EKONOMI DAN PEMASARAN USAHATANI TEMBAKAU RAKYAT (RAJANGAN) DI KABUPATEN LOMBOK TIMUR
Authors: Utama FR Aeko Fria , Efendy Efendy
Published: March 2024

Penelitian ini Bertujuan untuk mengetahui: (1) Keuntungan usahatani tembakau rajangan di Kabupaten Lombok Timur. (2) Tingkat kelayakan Ekonomi usahatani tembakau rajangan di Kabupaten Lombok Timur. (3) Pemasaran usahatani tembakau rajangan di Kabupaten Lombok Timur. (4) Masalah yang dihadapi petani dalam mengelola dan pemasaran usahatani tembakau rajangan di Kabupaten Lombok Timur. Penelitian ini menggunakan Metode deskriptif dilakukan di Kecamatan Suralaga, Kabupaten Lombok Timur, yang dipilih Secara purposive sampling dengan pertimbangan daerah dengan luas dan jumlah tertinggi produksi pertanian tembakau Rajangan. Sumber data dalam penelitian ini meliputi data primer dan data sekunder. Data primer dikumpulkan dengan metode survei terhadap 30 responden, dimana pemilihan dari responden dilakukan dengan teknik accidental sampling. Analisis data dalam penelitian ini menggunakan Analisis Kelayakan ekonomi dan Pemasaran. Hasil penelitian menunjukkan bahwa : (1) Keuntungan usahatani tembakau rajangan sebesar Rp 6.498.394,64/LLG atau Rp 25.993.578,57/Ha. (2) nilai R/C rasio yaitu 2,11>1 menunjukkan bahwa usahatani tembakau rajangan di Kabupaten Lombok Timur layak diusahakan. (3) saluran pemasaran tembakau rajangan di Kabupaten Lombok Timur terdapat satu lembaga pemasaran disetiap masing-asing desa yaitu lembaga pemasaran pedagang pengepul desa (PPDes). Dengan margin pemasaran terendah dari hasil produksi daun yang ke-4 dengan nilai Rp. 3.248.333,33, dan farmer’s share tertinggi dari hasil pemasaran produksi daun yang ke-4 sebesar 89,26%. Hal ini menunjukan bahwa pada pemasaran daun 4 lebih efisien dari pada daun lainnya. (4) masalah yang dihadapi petani dalam melakukan kegiatan usahatani tembakau rajangan yakni cuaca yang seringkali berubah-ubah dan ketersediaan pupuk yang terbatas. Sedangkan hambatan untuk saluran pemasaran yaitu tingkat harga yang tidak menentu yang diperoleh pedagang pengepul desa
ANALISIS KEMISKINAN RUMAH TANGGA PETANI DURIAN LOKAL DI KECAMATAN LINGSAR KABUPATEN LOMBOK BARAT
Authors: Sena Made Arya Bratha , Mandalika Eka Nurminda Dewi , Ayu Candra , Hidayati Asri
Published: March 2024

Kecamatan Lingsar merupakan salah satu sentra penghasil durian terbesar di Kabupaten Lombok. Usahatani durian lokal merupakan usahatani yang tergolong jangka panjang karena membutuhkan waktu yang cukup lama dalam proses usahataninya yang artinya pendapatan petani dari usahatani durian lokal tidak dapat mencukupi kebutuhan keluarga petani selama satu tahun penuh sehingga diperlukan penelitian untuk mengetahui tingkat kemiskinan rumah tangga petani durian. Kemudian dari hasil penelitian yang dilakukan diperoleh hasil:(1) Rata-rata produksi durian lokal di Kecamatan Lingsar pada satu tahun musim panen yaitu sebanyak 935 buah/LLG dan 858 buah/ha dengan harga rata-rata durian lokal per buah sebesar Rp. 25.233/buah sehingga dapat diperoleh nilai produksi petani pada usahatani durian lokal dengan luas lahan garapan 1,09 Ha sebesar Rp. 23.191.667/LLG/tahun dan Rp. 21.664.821/ha/tahun. Rata-rata pendapatan usahatani yaitu sebesar Rp. 14.649.628/LLG/tahun dan Rp. 13.828.088/ha/tahun; (2) Berdasarkan Kriteria Kemiskinan Sajogyo maka keluarga petani durian lokal di Kecamatan Lingsar Kabupaten Lombok Barat tergolong “Hampir Miskin” karena hasil pendapatan per kapita per tahun setara beras yang di peroleh berada diantara 320-480 Kg. Kemudian berdasarkan Kriteria Bank Dunia petani durian lokal di Kecamatan Lingsar tergolong “miskin” karena pendapatan perkapita pertahun setara dengan nilai tukar rupiah terhadap dollar Amerika berada dibawah US$ 784,75.
Os Técnicos em Assuntos Educacionais: Compreendendo o seu Lugar de Pertencimento nos Processos Educativos na Educação Profissional e Tecnológica - Um Instrumento Informativo para a Comunidade do Instituto Federal de Pernambuco (IFPE)
Authors: Silva Juliana de Cássia Maciel , Melo Filho Ivanildo José de
Published: March 2024

Trata-se de um livro digital resultante de uma pesquisa de mestrado do Programa de Mestrado Profissional em Educação Profissional e Tecnológica. Tem caráter não-regulatório, não-vinculante, resultante de investigação exploratória aplicada para este fim. É destinado exclusivamente a esclarecer dúvidas de modo a auxiliar a atuação dos Técnicos em Assuntos Educacionais (TAE's) e a articulação das suas atividades nos processos educativos perante a comunidade do IFPE. Cabe ressaltar ainda que essa proposta busca, sobretudo, nortear de maneira significativa as atividades desempenhadas pelos TAE's no âmbito da Educação Profissional e Tecnológica. As sugestões de atividades, por sua vez, aqui apresentadas podem ser utilizadas e adaptadas a partir da realidade de cada campus dos Institutos Federais do Brasil
Fisioterapia: uma abordagem contemporânea - Volume 5
Authors: Silva Marlla Souza da , Araruna Fernanda Oliveira Sousa , Maia Sandra Cristina , dos Santos Sousa Leydianne
Published: March 2024

A fisioterapia enquanto ciência do movimento humano, estuda os diversos sistemas responsáveis pelo adequado funcionamento das respostas motoras frente aos estímulos recebidos. Nessa obra, encontram-se reunidos trabalhos de conclusão de curso – TCC, abordando de forma integral os temas mais relevantes da área da fisioterapia, servindo de referência bibliográfica para atualização profissional e acadêmica. Os estudos aqui apresentados abrangem temas clássicos, contudo com uma perspectiva da reabilitação atual. Além disso, também estão disponíveis pesquisas que abordam assuntos mais complexos, de forma clara e concisa.
Integrando ferramentas tradicionais e tecnologias emergentes: Uma abordagem abrangente para o planejamento estratégico e avaliação financeira.
Authors: CANOVAS FELIPE ALLEGRETTI
Published: March 2024

O artigo aborda a importância crucial da eficiência das ferramentas no planejamento estratégico e na avaliação financeira de projetos em ambientes de negócios dinâmicos e competitivos. Destaca a necessidade de aplicação correta e integração efetiva dessas ferramentas para otimizar o desempenho organizacional, incluindo uma revisão bibliográfica e uma investigação de eficiência por meio de um estudo de caso no setor sucroalcooleiro. Ao integrar abordagens tradicionais e tecnologias emergentes, como inteligência artificial e big data, o artigo busca enfatizar a sinergia como crucial para decisões precisas e eficientes, apesar dos desafios associados à adoção de tecnologias emergentes. Conclui destacando a importância da revisão contínua e ajuste estratégico para garantir resiliência em ambientes empresariais em constante mudança.
IoT based weather monitoring system for temperature, humidity, rainfall and seismic detection in real time
Authors: Harshini M  , R. Vadivel
Published: March 2024

This paper presents the design and implementation of an IoT-based weather monitoring system enhanced with seismic detection capabilities, employing Node MCU microcontroller and the Blynk mobile application platform. The system incorporates various sensors including a rain sensor, Light light-dependent resistor (LDR), a DHT11 sensor for temperature and humidity measurement, and an accelerometer (MPU6050) for earthquake detection. The hardware components are interconnected with the Node MCU microcontroller, facilitating real-time data acquisition from the sensors. Programming of the Node MCU is conducted using the Arduino IDE, enabling data transmission to the Blynk app via Wi-Fi connectivity. The Blynk app serves as the user interface, allowing seamless visualization and monitoring of weather parameters and seismic activity on smartphones. Key functionalities of the system include periodic data collection from sensors, transmission of sensor data to the Blynk server, and updating of graphical representations in the Blynk app interface. The accelerometer sensor is utilized to detect changes in acceleration, indicative of seismic disturbances. Threshold values are defined to trigger alerts within the Blynk app in the event of potential seismic activity. The implementation undergoes rigorous testing to ensure accuracy, reliability, and responsiveness under diverse environmental conditions. Considerations such as network stability, power efficiency, and data security are addressed to enhance system performance and longevity. The system demonstrates promising capabilities for real-time weather monitoring and seismic event detection, offering valuable insights for disaster preparedness and environmental analysis. IoT-based weather monitoring system integrated with seismic detection provides an effective solution for comprehensive environmental monitoring, leveraging the power of IoT technology and mobile applications for enhanced data accessibility and analysis. Further advancements and optimizations can be explored to extend the functionality and scalability of the system for broader applications in environmental science and disaster management.
Strategic human resource management for sustainability in creative industries: A review and framework proposal
Authors: Irunna Ejibe  , David Olanrewaju Olutimehin  , Ekene Ezinwa Nwankwo
Published: March 2024

Strategic Human Resource Management (SHRM) has emerged as a critical approach for fostering sustainability within the dynamic landscape of creative industries. This review presents a comprehensive review of existing literature on SHRM in the context of creative industries, culminating in a proposed framework aimed at enhancing sustainability in these sectors. The review begins by examining the unique challenges faced by creative industries, characterized by rapid technological advancements, evolving consumer preferences, and intense competition. In this context, traditional HRM approaches are often insufficient, necessitating a strategic alignment between HR practices and organizational objectives to ensure long-term viability. Key themes identified in the literature review include talent management, organizational culture, employee engagement, and leadership development. Effective talent management strategies are crucial for attracting, retaining, and developing skilled individuals who drive innovation and creativity within creative firms. Furthermore, fostering a supportive organizational culture that values diversity, collaboration, and experimentation is vital for promoting sustainability in these industries. Employee engagement emerges as a critical factor influencing organizational performance and resilience, particularly in creative environments where intrinsic motivation plays a significant role. Moreover, leadership development programs tailored to the unique needs of creative professionals can empower individuals to navigate uncertainty and drive strategic initiatives that contribute to organizational sustainability. Building upon these insights, this review proposes a framework for SHRM in creative industries, integrating strategic planning, talent management, culture development, and leadership practices. The framework emphasizes the alignment between HR strategies and business goals, emphasizing the importance of agility, innovation, and adaptability in response to dynamic market conditions. Strategic Human Resource Management plays a pivotal role in enhancing sustainability within creative industries by fostering a culture of innovation, empowering employees, and cultivating leadership capabilities. The proposed framework provides a roadmap for organizations seeking to navigate the complexities of the creative landscape while maximizing long-term success and resilience.
The varied effects of protein intake during infancy, childhood, and adolescence: Associations with growth metrics, body composition, and pubertal development timelines
Authors: Nada Soliman  , Ashraf Soliman  , Fawzia Alyafei  , Sohair ElSiddig  , Nada Alaaraj  , Noor Hamed  , Shayma Ahmed  , Maya Itani
Published: March 2024

Introduction: Protein plays a crucial role in the growth and development of children, impacting various physiological functions and long-term health outcomes. Understanding the optimal protein intake during the dynamic stages of childhood is essential due to its significant implications for metabolic and hormonal pathways, as well as its association with childhood obesity and malnutrition. Review Methods: The review involved a systematic examination of existing literature, focusing on studies that explored the relationship between protein intake and children's growth, development, and health outcomes. Databases such as PubMed, Scopus, and Web of Science were searched using specific keywords, with the selection criteria emphasizing peer-reviewed articles, clinical trials, and observational studies in English, excluding non-human studies. Results: The analysis indicates that protein intake has a pivotal influence on children's growth patterns, body composition, and metabolic health. Findings suggest that both excessive and insufficient protein consumption can have adverse effects, highlighting the importance of balanced protein intake. The review also points out the critical impact of maternal dietary quality on infant growth and underscores the significance of protein source and quantity during complementary feeding in determining health outcomes. Conclusions: Optimal protein intake is vital for supporting children's growth and long-term health, necessitating tailored dietary strategies that accommodate the changing needs of growing children. Healthcare professionals and caregivers must be informed about the nuanced effects of protein to maintain normal growth and development while mitigating risks like obesity. Future dietary guidelines should consider these findings to ensure balanced nutrition for children at various developmental stages.
Sol Popülizmin Avrupa’daki Geleceği: Podemos ve Syriza Bağlamında Bir İnceleme
Authors: Meydan Vildan
Published: March 2024

Bu çalışma, sol popülizmin merkez Avrupa’ya sirayetini Yunanistan ve İspanya özelinde, Podemos ve Syriza hükümetleri bağlamında incelemektedir. Bu doğrultuda çalışma, tarihsel süreçte sol popülizmin iki ülkede yükselişe geçtiği ve ardından iktidarı kaybetme ile sonuçlanan süreci ele almakta, bu bağlamda sol popülizmin başarısızlığının sebeplerini sorgulamaktadır. Bu çerçevede çalışma Podemos ve Syriza’nın İspanya ve Yunanistan’da başarıya ulaşan ve kısa bir süre sonra ise düşüşe geçmesine neden olan politikalarını incelemektedir. Çalışmanın temel amacı, sol popülizmin vadettiği politikaların gerçekleştirilmesinde, partilerin iktidara geçmesi durumunda başarılı olup olmadıkları sorusunu ve dolayısıyla Avrupa’da sol popülizmin geleceğini Podemos ve Syriza örnekleri üzerinden incelemektir. Avrupa’da önemli etkilere sahip 2008 ekonomik krizinin gerek İspanya gerekse Yunanistan siyasal sistemlerinde sol popülizme hızlı bir ivme kazandırdığı görülmekle birlikte, mevcut siyasal yapıya bakıldığında iki ülkede de sol popülizmin etkisini kaybetmeye başladığı ortadadır. İspanya ve Yunanistan’da sol popülist parti ve liderlerin vadettiği ekonomik iyileşme gerçekleşmemiş, bu başarısızlık sol popülizmin yarattığı momentumun kaybolmasına neden olmuştur. Bu kapsamda çalışma, sağ popülizmin etkinliğini koruduğu Avrupa’da sol popülizmin popülerliğini kaybettiği, bununla birlikte halihazırda yaşanan ekonomik problemlerin sürmesi halinde eski etkinliğine dönme olasılığının da bulunduğu sonucuna varmıştır.