bluuebunny/crossref_metadata_2025 huggingface dataset:
Timing of Early Cholecystectomy: A Multicentric Prospective Observational Study
Authors: Fugazzola Paola , Abu-Zidan Fikri M , Cobianchi Lorenzo , Dal Mas Francesca , Ceresoli Marco , Coccolini Federico , Frassini Simone , Tomasoni Matteo , Catena Fausto , Ansaloni Luca , Collaborative Group S.P.Ri.M.A.C.C.
Published: September 2023

The definition of Early Cholecystectomy (EC) is still debatable. This paper aims to find whether the timing of EC affects outcomes. This is a multicentric prospective observational study including patients with acute calculous cholecystitis (ACC) who had cholecystectomy within ten days from the onset of symptoms. Kruskall-Wallis test, Fisher’s Exact test and Spearman rank correlation were used for statistical analysis. The patients were divided into three groups depending on the timing of the operation: 0-3 days, 4-7 days, or 8-10 days from the onset of symptoms. 1117 patients were studied over a year. The time from the onset of symptoms to EC did not affect the postoperative complications and mortality, the conversion and the reintervention rate. It was a significant risk factor for intraoperative complications (0-3 days, 2.8%; 4-7 days, 5.6%; 8-10 days, 7.9%; p=0.01) and subtotal cholecystectomies (0-3 days, 2.7%; 4-7 days, 5.6%; 8-10 days, 10.9%; p<0.001). ACC is an evolutive inflammatory process and, as the days go by, the local and systemic inflammation increases which makes surgery more complex and difficult with higher risk of intraoperative complications. We recommend performing EC for ACC as soon as possible within the first ten days of the onset of symptoms.
Analysis of Acoustic Flow Field Characteristics of Key Components of High-speed Train Bogies
Authors: Zhao Xing , Jia Xiaoyang , Li Lin , Wang Hanyu
Published: September 2023

In this paper, we aim to address the challenge of airflow interference during fault detection in high-speed train bogies by introducing a flow field and investigating the characteristics of the sound field distribution of critical components under its influence. This approach overcomes the limitation observed in previous studies that ignored the impact of the flow field. Furthermore, we evaluate and compare various layouts for inter-track acoustic sensor arrays. The proposed sensing methods hold significant practical engineering value, and the collected data serves as a valuable reference for acquiring acoustic signals from key bogie components in future research.
Bistability and Thermal Studies in High Index Doped Silica Integrated Ring Resonators
Authors: Moss David
Published: September 2023

The utilization and engineering of thermo-optic effects have found broad applications in integrated photonic devices, facilitating efficient light manipulation to achieve various functionalities. Here, we perform both an experimental characterization and theoretical analysis of these effects in integrated micro-ring resonators in high index doped silica (HIDS), which has had many applications in integrated photonics and nonlinear optics. By fitting the experimental results with theory, we obtain fundamental parameters that characterize their thermo-optic performance, including the thermo-optic coefficient, the efficiency for the optically induced thermo-optic process, and the thermal conductivity. The characteristics of these parameters are compared to those of other materials commonly used for integrated photonic platforms, such as silicon, silicon nitride, and silica. These results offer a comprehensive insight into the thermo-optic properties of HIDS based devices. Understanding these properties is essential for efficiently controlling and engineering them in many practical applications.
Enhanced UV-blocking Capabilities of Polylactic Acid Derived from Renewable Resources for Food and Drug Packaging: A Mini-Review
Authors: Ran Xiaxuan , Qu Yunzhuo , Wang Yijie , Cui Bowen , Shen Yushan , LI YUANZHE
Published: September 2023

Plastic materials have revolutionized modern life, particularly in the domain of food packaging, owing to their versatility, lightweight nature, and ease of processing. However, the environmental ramifications of non-degradable plastics have raised concerns. Polylactic acid (PLA), derived from renewable sources, presents a sustainable alternative due to its biodegradability and exceptional barrier, mechanical, and safety properties. Nevertheless, the high UV transmittance of PLA limits its use for photosensitive food and pharmaceutical packaging, where UV radiation can lead to nutritional loss and spoilage. Various methods have been explored to enhance the UV-blocking capabilities of PLA, including the integration of inorganic nanoparticles and surface coatings. Despite advancements, these approaches often compromise the inherent transparency of PLA. Incorporating large conjugated groups can maintain transparency but introduces additional challenges. This paper reviews modification methods to enhance PLA's UV-barrier properties and anticipates its expanded utility in food and drug packaging, promoting UV resistance and diversifying PLA's applications.
Implementing a Pulmonary Telerehabilitation Program for Young Adults with Post-COVID-19 Syndrome. A Brief Report
Authors: Esparza Wilmer , Noboa Alfredo , Madera Camila , Mina Naif , Acosta-Vargas Patricia , Acosta-Vargas Gloria , Carrión-Toro Mayra , Santórum Marco , Ayala-Chauvin Manuel , Santillán And Guillermo
Published: September 2023

The objective of this study was to analyze the effects of a pulmonary telerehabilitation (TR) program in young adults with post-COVID-19 syndrome. The information of sixteen students' medical files were analyzed and allocated to one of two groups (control=CG/experimental=EG). Twelve TR sessions were performed distantly and asynchronously at the EG patients' homes during 4-weeks. The program included diaphragmatic pattern breathing and aerobic exercises. The parameters: i) vital signs (oxygen saturation "SpO2", heart rate "HR", respiratory rate "RR" and blood pressure "BP"; ii) physical capacity “Sit-to-stand test”; iii) cardiorespiratory capacity “6-Minute Walk Test”; and iv) perceived effort "Borg scale" were assessed in both groups. The statistical analyses showed a significant decrease of RR and HR (p < 0.012) accompanied by a significant increase in SpO2 (p < 0.042), physical (p < 0.012) and respiratory (p < 0.028) capacity. The perceived effort decreased significantly in both groups (CG: p < 0.006; EG p < 0.001) only for physical but not for cardiorespiratory capacity (p < 0.106). There were no statistical changes registered in BP (p > 0.05). The current study suggests that a TR program that involves breathing and aerobics exercises is feasible and effective in treating post-COVID-19 syndrome in young patients.
Convergent and Disperse Cyclic Multiverse Model (CDCMM)
Authors: Fan Chian
Published: September 2023

This paper defines the concepts of four-dimensional "coordinate spacetime" and "measure spacetime", which unifies absolute spacetime and relative spacetime; it holds that all energy-momentum itself has spacetime attributes, and all interactions are mediated through spacetime metrics, which unifies the energy-momentum and the interactions. On this basis, a converging and dispersing cyclic multiverse model is argued. This model of the universe is inevitable as long as there are two macroscopic manifestations of the matter of the universe, gravitationally induced convergence and "explosive" diffusion caused by different factors. The new model of the universe matches the observed accelerated expansion of the universe and does not require the dark energy hypothesis.
Synthesis of Shaker Input Signals with High Kurtosis for Vibration Qualification Testing
Authors: Troncossi Marco , Pesaresi Emanuele , Rivola Alessandro
Published: September 2023

In many industrial, automotive, and aerospace applications, electro-mechanical systems are subjected to random vibration excitations, and the most critical components are required to undergo qualification tests to verify their suitability. Measured field data are commonly considered as reference for the synthesis of random stationary signals used as shaker input excitations in laboratory tests. For the most popular procedures of random-control testing, the user sets the input profiles in terms of power spectral density (PSD) associated with randomized phases generated by the shaker controller to finally provide the physical motion. As a result, the overall probability distribution of the test signal tends toward Gaussian, whereas many real-life random excitations prove non-Gaussian due to distinctive bursts and peaks. The quantitative estimate of the number and amplitudes of peaks present in a certain signal is usually made through the statistical parameter known as kurtosis. The so-called kurtosis control methods presented in the literature are conceived to perform qualification tests with random and non-Gaussian vibration excitations. In this paper, two novel algorithms able to synthesize shaker input signals for random-control testing with prescribed PSD and kurtosis value are proposed, and the results of their application are comparatively discussed to assess their effectiveness and potentialities in different kinds of qualification testing, including accelerated fatigue-life tests.
Effect of Body Weight Gain During Cashmere Non-Growing Period on Cashmere Production Performance and Secondary Hair Follicle Activity of Cashmere Goats
Authors: Li Junxia , Xing Wenhui , He Dong , Duan Xinming , Ji Yatu , Gegen Tana , Zhang Chunxiang , Ren Youshe , Yang Chunhe
Published: September 2023

The objective of this study was to investigate the effects of body weight gain during the cashmere non-growing period on cashmere production performance and secondary hair follicle activity, to provide a theoretical basis for appropriate supplementary feeding of cashmere goats. Fifty Inner Mongolian cashmere goats aged 2-4 years old were randomly selected and weighed in May and September 2019, respectively. Based on body weight gain between the two weights, the experi-mental ewe goats were divided into two groups: 0-5.0 kg group (n = 30) and 5.0-10.0 kg group (n = 20). Skin samples and cashmere samples were collected. Results of Pearson correlation analysis showed that body weight gain during the cashmere non-growing period had a moderate and strong positive correlation with cashmere yield (P = 0.021) and cashmere staple length (P = 0.002) respectively, but did not correlate with cashmere diameter (P = 0.254). Compared with cashmere goats with a body weight gain of 0-5.0 kg, cashmere goats with a body weight gain of 5.0-10.0 kg had a 17.10% increment in cashmere yield (P = 0.037), 8.09% increase in cashmere staple length (P=0.045) and had no significant difference in cashmere diameter (P = 0.324). Results of Pearson correlation analysis showed that there was a strong positive correlation between body weight gain and the population of active secondary hair follicles in the skin of cashmere goats (P < 0.01). Compared with cashmere goats with a body weight gain of 0-5.0 kg, cashmere goats with a body weight gain of 5.0-10.0 kg had an increase in the population of active secondary hair follicles (P < 0.05). In conclusion, the body weight gain during the cashmere non-growing period had a sig-nificant effect on secondary hair follicle activity and cashmere production performance in cash-mere goats. Since body weight gain reflects nutritional level to a certain extent, this study suggests that nutritional manipulations such as supplementary feeding during cashmere non-growing periods can increase cashmere production performance. However, specific nutritional manipula-tions during the cashmere non-growing period need further research to increase cashmere pro-duction performance.
The Analysis of Conversational Implicature in an Extensive Listening of BBC Learning English Podcast
Authors: Dwiwulandari Retno , Dewanti Ratna
Published: September 2023

Using qualitative content analysis, this study attempts to investigate the occurrence of conversational implicature in an extensive listening of BBC Learning English Podcast. This study was conducted to find out how conversational implicature is employed by the speakers, including the types and functions of the implicature. Following Grice’s theory of conversational implicature and cooperative principle, this study revealed that out of 200 samples taken, the implicature occurred in 104 utterances which were generated through flouting and violation with Particularized Conversational Implicature (PCI) dominating the exchange rather than Generalized Conversational Implicature (GCI). As for the function of implicature produced, the researcher utilized Searle’s theory of Speech Act which comprises Assertive, Commissive, Declarative, Directive, and Expressive. The result showed that Assertive function dominates the utterance produced, meanwhile Declarative function was absent. The findings and result of this study is expected to be able to give some instances to the learners of English to the theory of conversational implicature, so that they will learn to avoid misunderstanding during the conversation itself. It is also expected to give contribution to the field of pragmatics, since, to the researcher’s knowledge, the study of conversational implicature on the same media is still scarcely conducted.
The Incorporation of High Order Thinking Skills in Exercises of the Eleventh Graders English Textbook
Authors: Fakhira Jihan , Iskandar Ifan
Published: September 2023

This study was qualitative research using content analysis that aimed to investigate to what extent high order thinking skills (HOTS) are incorporated in the reading exercises of English textbook for 11th graders and to describe how HOTS are incorporated in the reading exercises. This study used Bloom’s Revised Taxonomy (BRT) table and the table of description was used to examine 107 essay reading exercises that come after every reading passage in a textbook published by the Ministry of Education and Culture of Indonesia. The findings showed that (1) the HOTS in the reading questions were available in 50 questions (46,7%) while the LOTS were in 57 questions (53,3%). (2) The HOTS questions required students to analyze the storyline from the reading passage, to argue their opinion or judge if they liked the reading text, to assess their own knowledge as their awareness were raised or changed toward the topic, and the last to create a new ending of the story. The findings of this research are expected to be the references for teachers to check the incorporation of HOTS in the exercises before they give to the students.
Digital Scrapbook for Learning Recount Text in Junior High School
Authors: Salsabillah Audy , Mayuni Ilza
Published: September 2023

This study aimed to see the relevance of the contents of digital scrapbooks published by Kate Hadfield  Designs with the Curriculum 2013 to learn recount text in Junior High School. The research data were the  sentences which were stated in twenty digital scrapbooks from the Kate Hadfield Designs website  katehadfielddesigns.com and Pinterest of Kate Hadfield Designs. The generic structure analysis proved that all the elements implemented in the text are well structured. The majority of the texts of digital  scrapbooks have been written in the form of a language feature of recount text stated by experts.  Nevertheless, the researcher still found several language features missing from some of the texts. For the  social function, all the digital scrapbooks were in line with the Curriculum 2013. Furthermore, it could be  concluded that the digital scrapbooks analyzed in this research accomplished the necessity of adequate  recount text and was relevant with the Curriculum 2013.
The Alignment between Learning Outcomes and Assessment Tasks in Writing: A BRT Analysis
Authors: Ulfie Fauziana , Permana Sudarya
Published: September 2023

This study was aimed at obtaining the profile of alignment between learning outcomes and assessment tasks on ‘writing’ skills development in “Pathway to English Grade X” textbook with regards to Bloom’s Revised Taxonomy. The data of the study were 32 statements of learning outcomes and 49 items of assessment tasks of 10 chapters. This study used Bloom’s Revised Taxonomy table (Anderson & Krathwohl, 2001) as the framework of reference in conducting data collection and interpretation. The results showed that the LOs and ATs distributed over several levels. 34.38% of overall LOs of this textbook are described in level B4 (Analyze, Conceptual Knowledge), and 22.45% of overall ATs are described in level B2 (Understand, Conceptual Knowledge). In the textbook, it was found that 69.39% of the overall ATs match with the LOs in the textbook. 20.41% of the overall ATs partially match with the LOs, and 10.20% of the overall ATs do not match with the LOs in the textbook. The results showed that the alignment between the learning outcomes and assessment tasks on ‘writing’ skills development in this textbook is strong or the percentage is more than 50%.
Alignment of Assessment Tasks with the Intended Learning Outcomes in “EPP” and “EMS” courses of ELESP UNJ: A Content Analysis
Authors: Akbar Intan Miutiara , Sulastini Sri
Published: September 2023

This study aims at investigating the extent to which assessment tasks (ATs) and intended learning outcomes (ILOs) in Phonetics & Phonology (EPP) and English Morphology & Syntax (EMS) courses of ELESP are well aligned, and how their alignment with the knowledge (KD) and cognitive process dimension (CPD) is. Deductive qualitative content analysis techniques were implemented on the RPS document and assessment tools. It was found that 83% of the ATs in the EPP course are well-aligned with the ILOs. They support the students’ ability to Remember (8,82%), Understand (20,59%), and Apply (41,18%) the Conceptual (82,35%) and Procedural (17,65%) knowledge, while Analyze and Evaluate cover 2,94% and 26,47% respectively. However, the ATs tested students’ ability to Understand (25%) and Apply (75%) Conceptual (95%), and Metacognitive (5%) knowledge resulting in a misaligned teaching and learning exercise. In the EMS course, three out of six items (50%) of ATs are partially aligned, while only one AT (17%) is well-aligned with the ILOs. The ILOs support the students’ ability to Understand (50%) Conceptual (66,67%) and Metacognitive (33,33%) knowledge while the Analysis covers 50%. However, the ATs tested students’ ability to Understand (66,67%) and Apply (33,33%) Conceptual (100%) knowledge was misaligned.
Conversation Analysis: Turn-Taking Analysis in Variety’s Actors on Actors Conversation Video featuring Zendaya and Andrew Garfield
Authors: Noval Ahmad Yazid , Athallah Aufa Tsabitah , Pujiati Hanip
Published: September 2023

This study is proposed to analyze conversation analysis, especially for turn-taking strategy in a video of Actors on Actors Conversation by Variety featuring Zendaya and Andrew Garfield. This study used a qualitative method with Stenstrom’s framework to analyze the turn-taking strategy used in the conversation. The process of analysis consists of four steps; streaming Variety’s Actors on Actors Conversation video featuring Zendaya and Andrew Garfield, transcribing the conversation, classifying the data, and interpreting the data. The result of this study showed that turn-taking strategies appear in the conversation. There were starting up, promoting, interrupting, repeating words, taking over, overlapping, appealing, silent pauses, and filled pauses. The most frequent turn-taking strategy used is the overlapping strategy. Therefore, this study suggests that conversation analysis is important for understanding the intent of people's speech. In addition, this study can be used as a reflection on both theoretical and practical contributions. In theory, this study supports the theory of conversation analysis in turn-taking strategies. In fact, teachers can use it as a reference for applied linguistics courses.
The Forms of Citation Practices in the Undergraduate Students’ Theses in English Language Teaching
Authors: Saura Yolanda , Darya I Wayan
Published: September 2023

This study aims to find out the forms used in citation practices of ELESP undergraduate students’ theses at Universitas Negeri Jakarta. This research uses both quantitative and qualitative methods, which employ a corpus-based analysis. The analysis is conducted by adopting Hyland (1999)’s framework of citation category and citation integration as proposed by Swales (1990). The data source of this research consists of 50 theses in English Language Teaching (ELT), especially the introduction and literature review chapters, written by ELESP undergraduate students published from 2018 to 2022 in the repository of UNJ. The results revealed that ELESP undergraduate students frequently use summary and generalization in the introduction and literature review chapter. Furthermore, the use of integral and non-integral forms in the two chapters have nearly the same frequency, which indicates that the students focus on the actions of researchers as well as emphasize the research itself in the cited sources.
Unified metagenomic method for rapid detection of bacteria, fungi and viruses in clinical samples
Authors: Alcolea-Medina Adela , Alder Christopher , Snell Luke , Charalampous Themoula , Aydin Alp , Nebbia Gaia , Williams Tom , Goldenberg Simon , Douthwaite Samuel , Batra Rahul , Cliff Penelope , Mischo Hannah , Neil Stuart , Wilks Mark , Edgeworth Jonathan
Published: September 2023

Clinical metagenomic sequencing can detect microorganisms causing infection directly from clinical samples. Depletion of host DNA is key to increasing sensitivity and reducing turnaround time (TAT). Several human DNA depletion methods have been previously published for detecting microorganisms with DNA and RNA genomes in clinical samples using metagenomics techniques, however, these methodologies only allow for the detection of either DNA or RNA microbes, but not both simultaneously. Thus, we have developed a mechanical-based human DNA depletion method that allows simultaneous detection of RNA and DNA microorganisms, including viruses, bacteria and fungi, directly from clinical samples using Oxford Nanopore Technology. The method is technically easy and rapid to perform and successfully removes human DNA from the samples, decreasing human DNA detection with a media of eight Ct values. Workflow detects a broad range of organisms: RNA & DNA viruses, bacteria (Gram-negative and Gram-positive and atypical respiratory pathogens (legionella, chlamydia, mycoplasma) and fungi (Candida, Pneumocystis, Aspergillus)​ 2-hour reports have > 90% sensitivity for bacterial and viral detection compared with routine laboratory results. Positive results are first reportable after 30 min sequencing in a 7h end-to-end workflow.​ The whole genome sequence was achieved in 42% of the viruses detected.
Identifying the genetic links between Parkinson’s disease and non-motor symptoms: novel insights into disease mechanisms
Authors: O'Sullivan Justin , Gokuladhas Sreemol , Fadason Tayaza , Farrow Sophie , Cooper Antony
Published: September 2023

Understanding the biological mechanisms that underlie the non-motor symptoms of Parkinson’s disease (PD) requires comprehensive frameworks that unravel the complex interplay of genetic risk factors. Here, we used a disease-agnostic brain cortex gene regulatory network integrated with Mendelian Randomization analyses to identify 19 genes whose changes in expression are causal for PD. We further used the network to identify genes that are regulated by PD-associated genome-wide association study (GWAS) SNPs. Extended protein interaction networks derived from both the causal genes and PD-associated SNPs identified convergent impacts on biological pathways and phenoytpes, connecting PD with established co-occurring traits, including non-motor symptoms. These findings hold promise for therapeutic development. In conclusion, while distinct sets of genes likely influence PD risk and outcomes, the existence of genes in common and intersecting pathways suggests that they may contribute to both increased disease risk and symptom heterogeneity observed in people with Parkinson’s.
Spatiotemporal imaging and shaping of electron wave functions using novel attoclock interferometry
Authors: Liu Yunquan , Ge Peipei , Dou Yankun , Han Meng , Fang Yiqi , Deng Yongkai , Wu Chengyin , Gong Qihuang
Published: September 2023

Electrons detached from atoms by photoionization carry valuable information about light-atom interactions. Characterizing and shaping the electron wave function on its natural timescale is of paramount importance for understanding and controlling ultrafast electron dynamics in atoms, molecules and condensed matter. Here we propose a novel attoclock interferometry to shape and image the electron wave function in atomic photoionization. Using a combination of a strong circularly polarized second harmonic and a weak linearly polarized fundamental field, we spatiotemporally modulate the atomic potential barrier and shape the electron wave functions, which are mapped into a temporal interferometry. By analyzing the two-color phase-resolved and angle-resolved photoelectron interference, we are able to reconstruct the spatiotemporal evolution of the electron wave function in momentum space within the optical cycle, including its amplitude and phase, from which we identify the quantum nature of strong-field ionization and reveal the effect of the spatiotemporal properties of atomic potential on the departing electron. This study provides a new approach for spatiotemporal shaping and imaging of electron wave function in intense light-matter interactions and holds great potential for resolving ultrafast electronic dynamics in molecules, solids, and liquids.
Predicting return of lung function after a pulmonary exacerbation using the cystic fibrosis respiratory symptom diary-chronic respiratory infection symptom scale
Authors: Gill Eliana R. , Goss Christopher H. , Sagel Scott D. , Wright Michelle L. , Horner Sharon D. , Zuñiga Julie A.
Published: September 2023

Background
Pulmonary exacerbations (PExs) in people with cystic fibrosis (PwCF) are associated with increased healthcare costs, decreased quality of life and the risk for permanent decline in lung function. Symptom burden, the continuous physiological and emotional symptoms on an individual related to their disease, may be a useful tool for monitoring PwCF during a PEx, and identifying individuals at high risk for permanent decline in lung function. The purpose of this study was to investigate if the degree of symptom burden severity, measured by the Cystic Fibrosis Respiratory Symptom Diary (CFRSD)- Chronic Respiratory Infection Symptom Scale (CRISS), at the onset of a PEx can predict failure to return to baseline lung function by the end of treatment.
Methods
A secondary analysis of a longitudinal, observational study (N = 56) was conducted. Data was collected at four time points: year-prior-to-enrollment annual appointment, termed “baseline”, day 1 of PEx diagnosis, termed “Visit 1”, day 10–21 of PEx diagnosis, termed “Visit 2” and two-weeks post-hospitalization, termed “Visit 3”. A linear regression model was performed to analyze the research question.
Results
A regression model predicted that recovery of lung function decreased by 0.2 points for every increase in CRISS points, indicating that participants with a CRISS score greater than 48.3 were at 14% greater risk of not recovering to baseline lung function by Visit 2, than people with lower scores.
Conclusion
Monitoring CRISS scores in PwCF is an efficient, reliable, non-invasive way to determine a person’s status at the beginning of a PEx. The results presented in this paper support the usefulness of studying symptoms in the context of PEx in PwCF.
RETRACTED: Characterization and screening for inoculation of rhizobium and PGPR for improving growth of mash bean under axenic conditions
Authors: Asif Kashiuf , Asghar Hafiz Naeem , Zahir Zahir Ahmad , Waraich Ejaz Ahmad
Published: September 2023

The authors have requested that this preprint be removed from Research Square.
Catastrophizing maladaptive coping affects influence of viral anxiety on fear of progression in cancer patients during COVID-19 pandemic
Authors: Lee Hyuk Joo , Sin Cheolkyung , Kim Hyeyeong , Im Hyeon-Su , Jo Jae-Cheol , Lee Yoo Jin , Kim Youjin , Ahn Junseok , Yoo Soyoung , Koh Su-jin , Chung Seockhoon
Published: September 2023

Background/Aims
The aim of the present study was to explore whether or not cancer patients’ viral anxiety and depression during the coronavirus 2019 (COVID-19) pandemic were associated with a fear of cancer progression. We also assessed whether coping strategies affected the relationship.
Methods
The present cross-sectional survey included cancer patients who visited Ulsan University Hospital in Ulsan, Korea. The participants’ demographic information and responses to the following symptoms rating scales were collected: Stress and Anxiety to Viral Epidemic − 6 (SAVE-6); Patient Health Questionnaire − 9 (PHQ-9); Cognitive Emotion Regulation Questionnaire - short version (CERQ-short); or Fear of Progression Questionnaire - short version (FoP-Q-SF).
Results
Of the 558 cancer patients surveyed, 25 (4.5%) reported that their treatment schedule was delayed during the COVID-19 pandemic. The patients’ fear of progression was found to be related to age (β = -0.08; P = 0.011), viral anxiety (β = 0.40; P < 0.001), depression (β = 0.26; P < 0.001), and catastrophizing coping strategies (β = 0.15; P = 0.004), for an overall adjusted R2 of 0.46 (F = 66.8; P < 0.001). Mediation analysis showed that viral anxiety and depression directly influenced fear of progression, while catastrophizing mediated this relationship.
Conclusions
Fear of progression in cancer patients was influenced by viral anxiety, depression, and maladaptive coping techniques, such as catastrophizing, during the COVID-19 pandemic.
Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutations
Authors: Silverman Jill L. , Fenton Timothy , Haouchine Olivia , Hallam Elizabeth , Smith Emily , Jackson Kiya , Rahbarian Darlene , Canales Cesar , Adhikari Anna , Nord Alex , Ben-Shalom Roy
Published: September 2023

SYNGAP1 is a critical gene for neuronal development, synaptic structure, and function. Although rare, the disruption of SYNGAP1 directly causes a genetically identifiable neurodevelopmental disorder (NDD) called SYNGAP1-related intellectual disability. Without functional SynGAP1 protein, patients present with intellectual disability, motor impairments, and epilepsy. Previous work using mouse models with a variety of germline and conditional mutations has helped delineate SynGAP1’s critical roles in neuronal structure and function, as well as key biochemical signaling pathways essential to synapse integrity. Homozygous loss of SYNGAP1 is embryonically lethal. Heterozygous mutations of SynGAP1 result in a broad range of phenotypes including increased locomotor activity, impaired working spatial memory, impaired cued fear memory, and increased stereotypic behavior. Our in vivo functional data, using the original germline mutation mouse line from the Huganir laboratory, corroborated robust hyperactivity and learning and memory deficits. Here, we describe impairments in the translational biomarker domain of sleep, characterized using neurophysiological data collected with wireless telemetric electroencephalography (EEG). We discovered Syngap1+/− mice exhibited elevated spike trains in both number and duration, in addition to elevated power, most notably in the delta power band. Primary neurons from Syngap1+/− mice displayed increased network firing activity, greater spikes per burst, and shorter inter-burst intervals between peaks using high density micro-electrode arrays (HD-MEA). This work is translational, innovative, and highly significant as it outlines functional impairments in Syngap1 mutant mice. Simultaneously, the work utilized untethered, wireless neurophysiology that can discover potential biomarkers of Syngap1R-ID, for clinical trials, as it has done with other NDDs. Our work is substantial forward progress toward translational work for SynGAP1R-ID as it bridges in-vitro electrophysiological neuronal activity and function with in vivo neurophysiological brain activity and function. These data elucidate multiple quantitative, translational biomarkers in vivo and in vitro for the development of treatments for SYNGAP1-related intellectual disability.
Oxytocin infusion for maintenance of uterine tone under prophylactic phenylephrine infusion for prevention of post-spinal hypotension in cesarean delivery: a prospective randomised double-blinded dose-finding study.
Authors: Jin Xiao-Qin , Shen Yao-Hua , Fu Fan , Yu Juan , Xiao Fei , Huang Xiao-Dong
Published: September 2023

Background:
Prior studies have shown that, when administered as an intravenous bolus to prevent uterine atony, prophylactic phenylephrine infusion increased the dose requirement of oxytocin and second-line uterotonics. For the prevention of uterine atony, oxytocin should be delivered by continuous infusion. Here, we aimed to determine the ED50 and ED90 parameters (the effective doses for 50% and 90% patients without uterine atony) of oxytocin for co-infusion with prophylactic phenylephrine during cesarean delivery.
Methods:
In this prospective randomized double-blinded dose-finding study, one hundred patients were divided into four groups to receive 2.5, 5.0, 7.5, or 10 IU/h oxytocin infusion, after the umbilical cord was clamped during the study period. The uterine tone was evaluated and defined as either adequate or inadequate. Probit regression analysis was applied to calculate the ED50 and ED90 of oxytocin infusion. Uterine tone, the percentage of patients who needed additional oxytocin bolus, second-line uterotonics, side effects, estimated blood loss, and neonatal outcomes were monitored.
Results:
The estimated ED50 and ED90 values of the oxytocin infusion doses for the prevention of uterine atony were 1.9 IU/h (95% CI -4.6-3.8) IU/h and 9.3 IU/h (95% CI 7.3-16.2) IU/h, respectively. Across groups, there was a significant linear trend between the infusion dose and the percentage of patients who required additional oxytocin (p-value = 0.002). No differences were observed in the incidence of side effects and neonatal outcomes.
Conclusion:
Under the conditions of this study, the ED90 of oxytocin infusion for the prevention of uterine atony was 9.3 IU/h, which is higher than the current recommendation. This finding is helpful for clinical practice, because of the routine use of phenylephrine in cesarean delivery. Further studies are needed to determine the appropriate initial bolus of oxytocin after neonatal delivery.
Trial registration:
The study was registered on the Chinese Clinical Trial Register (register no. ChiCTR2200059556).
RUL: https://www.chictr.org.cn/showproj.html?proj=153116
Key elements and contextual factors that influence successful implementation of large-system transformation initiatives in the New Zealand health system: A realist evaluation
Authors: Sharma Kanchan M , Jones Peter B , Cumming Jacqueline , Middleton Lesley
Published: September 2023

Background
Despite three decades of policy initiatives to improve integration of health care, delivery of health care in New Zealand remains fragmented, and health inequities persist for Māori and other high priority populations. An evidence base is needed to increase the chances of success with implementation of large-system transformation (LST) initiatives in a complex adaptive system.
Methods
This research aimed to identify key elements that support implementation of LST initiatives, and to investigate contextual factors that influence these initiatives. The realist logic of enquiry, nested within the macro framing of complex adaptive systems, formed the overall methodology for this research and involved five phases: theory gleaning from a local LST initiative, literature review, interviews, workshop, and online survey. We explained variations in success (outcomes) by identifying mechanisms triggered by various contexts in which LST initiatives are implemented.
Results
The research found that a set of 10 key elements needs to be present in the New Zealand health system to increase chances of success with implementation of LST initiatives. These are: (i) an alliancing way of working; (ii) a commitment to te Tiriti o Waitangi; (iii) an understanding of equity; (iv) clinical leadership and involvement; (v) involved people, whānau, and community; (vi) intelligent commissioning; (vii) continuous improvement; (viii) integrated health information; (ix) analytic capability; and (x) dedicated resources and time. The research identified five contextual factors that influenced implementation of LST initiatives: a history of working together, distributed leadership from funders, the maturity of Alliances, capacity and capability for improvement, and a continuous improvement culture.
Conclusions
Use of informal trust-based networks provided a critical platform for successful implementation of LST initiatives in the New Zealand health system. Maturity of these networks depends on the key mechanism of trust, that is built and nurtured over time through sharing of power by senior health leaders by practising distributed leadership. The role of central agencies and government is to provide the policy settings and conditions in which trust-based networks can flourish. The evidence base for successful implementation of LST initiatives produced in this research is transferrable to other regions and countries.
Individual Differences in Working Memory and the Impact on Students' Achievements in Solving Mathematical Problems in Analytic Geometry
Authors: Cohen Tirza , Paz-Baruch Nurit
Published: September 2023

The study explored the contribution of working memory (WM) components to analytic geometry achievements. According to Baddeley & Hitch’s (1974) Multicomponent Model, WM consists of three components: a phonological loop, a visuo-spatial sketchpad, and a central executive system. Few studies have focused on the role of WM mechanisms in analytic geometry. The participants in this study were 92 high school students (10th–11th grades). All students were tested on an analytic geometry test that included problems on three levels of difficulty. Additionally, the participants were tested on a battery of five memory tests that included all three components of WM. The findings suggest that after controlling for the grade level and the students' math scores, the central executive system accounted for 13% of the variance in analytic geometry, while the visuo-spatial sketchpad accounted for 7.9% of the variance. However, the phonological loop had no significant effect on students' achievements in analytic geometry. The results showed that students with a higher WM capacity also achieved better results at each level of difficulty on the analytic geometry test. The study’s findings may contribute to an understanding of the complex relationship between WM mechanisms and analytic geometry. The results can contribute to the theoretical knowledge regarding the correlation between the level of difficulty of a mathematical task and WM. Directions for future research and implications for practice are discussed.
Downregulation hsa_circ_0006620 inhibit the malignant progression of prostate cancer by regulation miR-502-3p/HK2 axis mediated aerobic glycolysis
Authors: Li Xue , Wang Menghan , Luo Yulin , Huang Qingqing , Huang Gang , Jin Mingming
Published: September 2023

Background: Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have been implicated in cancer progression by regulation metabolism. But, the circRNA roles in prostate cancer remains unknown.
Methods: This research aimed to use FISH and RT-qPCR to investigate hsa_circ_0006620 expression in prostate cancer cells and tissues after high-throughput sequencing. Our team made the luciferase reporter assay to validate hsa_circ_0006620 downstream target. Transwell migration assay, 5-ethynyl-20-deoxyuridine, and cell counting kit-8 were applied to investigate both proliferation and migration. In vivo tumorigenesis and metastasis assays were performed to investigate the hsa_circ_0006620 role in prostate cancer.
Results: The outputs elucidated that hsa_circ_0006620 expression incremented in prostate cancer cells and tissues. Hsa_circ_0006620 downregulation inhibited prostate cancer cell proliferation as well as migration in in vivo and in vitro experiments. The luciferase results validated that miR-502-3p and HK2 were hsa_circ_0006620 downstream targets. HK2 overexpression or miR-502-3p inhibition reversed prostate cancer cell migration after hsa_circ_0006620 silencing. The study also found that overexpression of HK2 or inhibition of prostate cancerreversed aerobic glycolysis after hsa_circ_0006620silencing.
Conclusion: Results demonstrate that hsa_circ_0006620 downregulation inhibits prostate cancer malignant progression by regulation miR-502-3p/HK2 axis mediated aerobic glycolysis.
Management of patients undergoing coronary angiography or percutaneous coronary interventions through the left distal trans-radial artery approach compared to the right conventional trans-radial artery approach
Authors: Elyamany Ehab , Galal Ayman , Abdelhady Yasser
Published: September 2023

Background
Lately, the alternative optimal approach for the access of the coronary artery was made through the left distal radial artery, either for diagnostic or interventional purposes. This study aimed to compare the safety and efficacy of the left distal trans-radial (ld-TRA) and conventional right trans-radial (RTRA) approaches for coronary procedures.
Patients and Methods:
This prospective cohort study was conducted on 100 patients who underwent coronary angiography and/or PCI in the Department of Cardiology of Beni-Suef University Hospital. Fifty patients underwent conventional right trans-radial access. The other fifty underwent left distal trans-radial approach from October 2018 to October 2019. The primary clinical outcomes were the complications at the blood vessel access site and the major induced adverse cardiac events. The secondary outcomes were the puncture time, the procedure time, the coronary cannulation time, the amount of dye injected, and the fluoroscopy time.
Results
there was an insignificant lower rate of crossover and complications in the ldTRA than in the RTRA. The coronary cannulation time was significantly lower in ldTRA (30 ± 7 seconds) than in RTRA (43 ± 11 seconds). Also, there was insignificant lower puncture time, duration of the procedure, amount of dye, and fluoroscopy time in the ldTRA than in the RTRA.
Conclusion
The access technique of the distal left radial artery is considered feasible and safe access for coronary interventions and angiography, with only a minor advantage over the right radial approach adding the benefit of the preservation of the radial artery for further revascularization procedures when needed.
Correlation between PRSS23 and Prognosis and Immune Regulation in Pancreatic Cancer
Authors: wang jingjing , deng zhe
Published: September 2023

Pancreatic cancer (PC) is a highly deadly solid malignant tumors with disrespectful prognosis, making appropriate biomarkers determination extraordinary crucial. Immune infiltration in tumor microenvironment is related to the subsistence of patients in PC. It has not been elaborated that the relationship between serum protease 23 gene (PRSS23) gene and the PC. We first determined the PRSS23 expression and its possible biological roles in PC, then analyses the TCGA and GEO data sets to check the possible carcinogenic effects of PRSS23.Moreover, the clinical value of PRSS23 was clarified through Kaplan-Meier Cox regression and prognostic nomogram model in PC. To examine the possible biological roles of PRSS23, GO analysis and KEGG analyses were accomplished. Using Tumor Immunity Estimation Resource (TIMER), We discover that the PRSS23 expression was raised in the PC tissue compared to corresponding non-cancerous tissue. High-PRSS23 expression is bound up with worse clinical pathological characteristics and worse prognosis in the PC. The correlation between PRSS23 and tumor infiltration was determined in tumor microenvironment (TME). Furthermore, functional enrichment analysis shows that PRSS23 may make a difference in impacting TME, cell adhesion and migration in PC tumor cell. This study maybe the first across-the-board discussion to reveal that the PRSS23 can be used as a new type of biomarker linked with immune infiltration and enlighten latent treatment targets in PC treatment.
Exploring key determinants of health among individuals with serious mental illness: Qualitative insights from a first episode psychosis cohort, 20 years postdiagnosis
Authors: Skjærpe Jorunn Nærland , Hegelstad Wenche ten Velden , Joa Inge , Storm Marianne
Published: September 2023

Background
Individuals with serious mental illness (SMI) are more likely to experience functional decline, low well-being, comorbidities, shorter lifespan, and diminished quality of life than the general population. This qualitative study explores determinants of health that individuals with SMI perceive as important to their health, well-being, and ability to live a meaningful life.
Method
We conducted interviews with 13 individuals with early detected first episode psychosis as part of a 20-year follow-up study of a larger cohort. Interview data were analyzed using qualitative content analysis.
Results
Analysis identified two themes comprising eight categories representing determinants of health. The first theme reflected management of mental and physical health. Categories in this theme were: access to mental healthcare adapted to individual needs, strategies during deterioration, use of psychotropic medication, maintenance of physical health and lifestyle. The second theme reflected social health determinants in coping with mental illness and comprised three categories: family and friends, engaging in meaningful hobbies and activities, and the influence of employment on mental health.
Conclusions
Individuals with SMI outlined mental, physical, and social determinants of health that were important for their health, well-being and ability to live a meaningful life. In future clinical practice, coordinated care addressing the complexity of health determinants will be important.
A Case-control study on the risk factors associated with the occurrence of non-tuberculous Mycobacte ria pulmonary disease in bronchiectasis patients
Authors: Feng Yinping , Guo Jing , Luo Shuirong , Zhang Zunjing
Published: September 2023

Objective To analyze the risk factors of bronchiectasis associated with non-tuberculous mycobacteria pulmonary disease, and provide basis for more effective prevention and treatment of BCS combined with NTM-PD.Methods The patients with bronchiectasis admitted to the infection department from January 2021 to June 2023 were selected as the study subjects, 34 patients with non-tuberculous mycobacteria pulmonary disease as the observation group, and 52 patients with simple bronchiectasis as the control group. Collect basic information, imaging features, serum albumin, and infection indicators from two groups of patients. Using univariate and multivariate logistic regression analysis to analyze the risk factors of NTM-PD in BCS patients.Results Multivariate logistic regression analysis showed that the acute exacerbation of bronchiectasis no less than 2 times a year (OR = 3.884, 95% CI: 1.200-12.568), number of bronchiectasis involved lung lobes no less than 3 pieces (OR = 3.932, 95% CI: 1.208–12.800), hypoalbuminemia (OR = 3.221, 95% CI: 1.015–10.219), and the NLR index (OR = 1.595, 95% CI: 1.200-2.119) were risk factors for bronchiectasis with non-tuberculous mycobacteria pulmonary disease (P < 0.05).Conclusion Patients with acute bronchiectasis no less than 2 times a year, number of bronchiectasis involved lung lobes no less than 3 pieces, hypoalbuminemia, and bronchiectasis with elevated NLR are more likely to be accompanied by non-tuberculous mycobacteria pulmonary disease, which should be prevented and treated as soon as possible.