bluuebunny/crossref_metadata_2025 huggingface dataset:
A Unified LOD Model for River Network and DEM Based on an Improved 3D_DP Algorithm
Authors: Dou Shiqing , Wang Han , Xu Yong , Deng Yuanxiang , Zhang Wenjie , Zhang Weidong
Published: July 2023

At present, the LOD modelling of vector and terrain data is individual, resulting in geometric and topological inconsistencies in simplification processes. This study proposes the "Bending Adjustment Index (BAI)" to improve the 3D_DP algorithm, called the improved 3D_DP algorithm, and putsforward a new unified LOD model for river network and DEM in three-dimensional space. The DEM data is extracted into a 3D discrete point dataset, the river line vector data is also converted into a discrete point dataset, assigned with elevation attributes, and merges with the DEM’s 3D discrete points. The merged point dataset issequenced based on the importance of each point, which is computed by the improved 3D_DP algorithm. The order of deleting points is determined by the sequence and the corresponding model spatial errors arecalculated with the deletion ofpoints. Then, the DEM’s 3D discrete points are constructed a Delaunay network with the river line as a mandatory constraint condition. The required triangulation is called in real time with the change of sight distance depending on the simple correspondence between screen projection error and model space error, and the unified LOD model for river line vector and DEM is established. The results show that the river's overall shape and the t errain's main features can be reserved under the same simplified factor based on the BAI improved 3D_DP algorithm. The unified LOD model for the river network and DEM is feasible under the importance sequence of merged point dataset by the improved 3D_DP algorithm. Under the proper operation of data blocking, the rendering frame rate can meet practical application requirements.
Recombinant growth arrest-specific protein 6 protects the blood–brain barrier by regulating microglia polarization via the GAS6/Axl/SOCS pathway in post-stroke hemorrhagic transformation model
Authors: Liu Jie , He Qian-Yan , Zhang Dian-Hui , Zhou Sheng-Yu , Sun Ying-Ying , Zhao Ruo-Yu , Pang Shu-Yan , Zhang Peng , Yang Yi , Guo Zhen-Ni
Published: July 2023

Background Blood–brain barrier (BBB) disruption is the primary cause of hemorrhagic transformation (HT) after ischemic stroke (IS). Axl is well-known as an essential innate immune regulator in macrophages. Our previous study have reported a negative association between serum Axl level and HT risk in patients after tPA thrombolysis, however, the underlying mechanism remains unclear. The present study was designed to investigate whether Axl activation could suppress BBB disruption and reduce HT in post-stroke HT model and the underlying mechanism.Methods and Results In vivo, the post-stroke HT model was established by an injection of 50% glucose and middle cerebral artery occlusion and reperfusion (MCAO/R) surgery 15min later in rats. Recombinant growth arrest-specific protein 6 (rGAS6) and R428 were injected as Axl-specific agonists and antagonists. Neurobehavioral deficits, infarction and hemorrhage volumes, brain edema, and the degree of BBB disruption were assessed. The expressions of GAS6, Axl, and suppressor of cytokine signaling (SOCS) pathway were measured. And the polarization states of microglia and the levels of inflammatory cytokines were analyzed. Our results showed that rGAS6 significantly improved neurological deficits, decreased infarct and hemorrhage volumes, alleviated brain edema and BBB disruption. Additionally, enhanced M2 polarization of microglia and a reduction in the inflammatory response were observed. Mechanism investigations suggested that rGAS6 upregulated Axl phosphorylation and the expressions of SOCS1/3. However, R428 injection abrogated the neuroprotection caused by rGAS6. The in vitro studies further supported the data of in vivo experiments, that rGAS6 treatment enhanced M2 polarization of microglia after oxygen and glucose deprivation/reoxygenation (OGD/R) stimulation via activating GAS6/Axl/SOCS1/3 pathway, which then influenced endothelial cell function.Conclusions Consequently, these data suggested that rGAS6 can protect BBB function and attenuate HT by enhancing microglial M2 polarization through activation of GAS6/Axl/SOCS signaling, and thus support rGAS6 as an effective immune modulator for the clinical prevention and treatment of IS-induced HT.
Analysis of cumulative live birth rate outcomes of three controlled ovarian hyperstimulation protocols in patients with diminished ovarian reserve following laparoscopic cystectomy of ovarial endometrioma: A retrospective cohort study
Authors: Li Jiaheng , Li Yijiang , Li Mengnuo , Zhao Xianling , Zheng Wei , Zhang Junwei , Zhang Yuchao , Li Jing , Guan Yichun
Published: July 2023

Background:To compare the assisted reproductive outcomes of gonadotropin (Gn)-releasing hormone (GnRH) antagonist, microstimulation, and progestin-primed ovarian stimulation (PPOS) protocols in patients with diminished ovarian reserve (DOR) following laparoscopic cystectomy of ovarial endometrioma.
Methods:In this retrospective cohort study, 89 patients with DOR who had undergone in vitro fertilisation/intracytoplasmic sperm injection at the Department of Reproductive Medicine at the Third Affiliated Hospital of Zhengzhou University from 1 January 2018 to 31 December 2020 were included. According to the controlled ovarian hyperstimulation protocols employed, the patients were divided into GnRH antagonist (38 patients), PPOS (27 patients), and microstimulation (24 patients) groups. The basic data and clinical outcomes of the three groups were compared. The main outcome measure was the cumulative live birth rate.
Results:No significant differences in the age of the female patients and their spouses and female patients’ body mass index and basal endocrine levels (follicle-stimulating hormone and oestradiol) were noted among the three groups (P > 0.05). The GnRH antagonist group had higher antral follicle counts, greater endometrial thickness on the human chorionic Gn injection day, greater number of oocytes retrieved, and higher two pronuclear embryo counts than did the other two groups. However, the starting dosage of Gn was lower in the GnRH antagonist group than in the other two groups. The microstimulation group had a significantly higher oocyte output rate and high-quality embryo rate than did the other two groups (P < 0.05). No significant differences in the total dosage of Gn, cumulative pregnancy rate, cumulative live birth rate, viable embryo rate, and blastocyst formation rate were observed among the three groups (P > 0.05).
Conclusion: For patients aged under 40 years who experienced DOR following laparoscopic cystectomy of ovarial endometrioma, the clinical outcomes of the three controlled ovarian hyperstimulation protocols were similar. However, the cumulative live birth rate was higher in the GnRH antagonist and PPOS groups than in the microstimulation group.
Effects of climate change and variability on thermal regime and dissolved oxygen resources of oligotrophic lakes in the Adirondack Mountain region
Authors: Bukaveckas Paul A. , Buikema Liz , Stewart Caitlin
Published: July 2023

An analysis of multi-decadal (1994-2021) temperature and dissolved oxygen profiles revealed a generally consistent pattern of response to climate change and variability among oligotrophic lakes in the Adirondack Mountain region. Regional increases in annual average air temperature (0.34 ± 0.09 oC per decade) were accompanied by warming and thinning of epilimnia, cooling and expansion of hypolimnia, and declining hypolimnetic dissolved oxygen. Lakes in this region are recovering from acidification and we hypothesize that associated increases in dissolved color have caused greater heat trapping in the surface layer and earlier onset of stratification. The combined effects of increasing air temperature and declining water clarity resulted in stronger thermal stratification and greater cumulative oxygen depletion in bottom waters. Lake bathymetry was a key variable determining the sensitivity of lakes to climate effects on oxygen resources. Lakes with thin hypolimnia exhibited low dissolved oxygen concentrations, which were exacerbated by strengthening of vertical temperature gradients and earlier onset of stratification. Photic depths are decreasing faster than mixing depths such that declines in photosynthesis may contribute to lower dissolved oxygen in deeper layers. We predict that with climate warming fewer Adirondack lakes will provide suitable habitat for cold water fisheries such as brook trout due to decreasing hypolimnetic oxygen.
The Effect of Information Disclosure on Donor Commitment: The Case of Waqf Institution
Authors: Mohamad Isa Abd Jalil  , Sofri Yahya  , Anwar Allah Pitchay
Published: July 2023

This is an extension of an earlier study that examined the relationship between information disclosure on donor commitment related to waqf institution. Data was obtained from a sample of 558 individuals in Malaysia who are a repeating cash donor to waqf. Partial least squares-structural equation modelling (PLS-SEM) test using SmartPLS was used for data analysis. The findings indicated that future information disclosure and waqif (the person who gives waqf) significantly influenced the latter’s commitment. Additionally, the waqf, or trust in English, plays a role as a mediator between future information disclosure and governance information disclosure to the waqif’s commitment. This theoretical contribution has a practical implication as well in that, it indicates to the waqf or trust to disclose their report to donors to ensure sustainable collection.
Time-Frequency Impact of Human Well-Being and Economic Growth on the Ecological Footprint: A Vietnamese Perspective
Authors: Ha Minh Hieu
Published: July 2023

The nexus between natural resources and environmental degradation has significant implications. Nevertheless, this domain is insufficiently examined. This paper therefore a examines the time-frequency influence of economic growth, human development, and urbanisation on Vietnam’s ecological footprint (EF) using wavelet analysis. The findings showed that the intercorrelation between EF and related variables is statistically significant at low, medium, and high frequencies. More importantly, the elationships between these variables occur at a high frequency, which means that EF, economic growth (GDP), human development index (HDI), and urbanisation (UB) have different fluctuations in the long run. These outcomes are also confirmed by the wavelet-based Granger causality test at various time scales, which supports our relationship results
The Role of Fund Managers in Diversifying Endowment Investment Portfolios of Malaysian Public Universities
Authors: Nurul Adilah Hasbullah  , Asmak Ab Rahman
Published: July 2023

Endowment is one of the most important sources of income globally for higher education institutions, and it should be invested for permanent use. Unfortunately, such funds are not optimally managed in Malaysia’s public universities. Therefore, this study was conducted to find ways to manage funds effectively among universities with the highest recorded collection of endowment funds. The participating universities in the study were: Universiti Malaya, Universiti Kebangsaan Malaysia, and Universiti Teknologi Malaysia. Interviews were conducted with representatives from their financial divisions. This study found that endowment funds in Malaysian public universities can be better invested with the appointment of dedicated fund managers. Their role is to assess the assets in which to invest with their expert knowledge to enhance the investment portfolio of endowment funds.
The Moderating Effects of State Ownership and Duality on the Relationship between Internationalisation and Firm Performance: A Case Study of Listed Firms in Vietnam
Authors: Anh Que Tran  , Dut Van Vo
Published: July 2023

This study was aimed at assessing the moderating effects of state ownership and chief executive officer (CEO) duality on the relationship between internationalisation and the performance of listed firms in the Hanoi Stock Exchange (HNX). A detailed panel data set of listed firms between 2009 and 2018 was analysed and the ordinary least squares (OLS) results revealed that the performance of high internationalising firms with high state ownership was higher than that of those with low or non-state ownership. In contrast, the performance of high internationalising firms governed by CEO duality was lower than that of those without duality. The findings integrate the arguments of the resource-based view and the Uppsala model applied in the transition economy that suggest internationalising listed firms acquire certain benefits from the state, and the separation of the highest two positions in such firms facilitates the exact anticipation of uncertainties and risks in making business decisions.
Populations of long-clawed crayfish Pontastacus leptodactylus: Effect of commercial fishing on the size and age structure
Authors: Alekhnovich A. V.
Published: July 2023

Fishing affects the population of crayfish, while it changes the size and age characteristics. The size and age parameters of two populations of the narrow-clawed crayfish Pontastacus leptodactylus in the Loktyshi (Brest Region) and Krasnoslobodskoe (Minsk Region) reservoirs in Belarus have been compared. The Krasnoslobodskoye reservoir is intensively exploited with an annual catch of 3–4 tons of crayfish. There is no commercial fishing in the Loktyshi reservoir. Studies show that the average size of individuals in an intensively exploited population is smaller in comparison with a population where there is no commercial fishing for crayfish. Since crayfish fishing is regulated by a commercial measure (10.5 cm of total length) in intensively exploited populations, the average sizes of individuals are close to these limiting values. The life expectancy of crayfish is somewhat higher in the Loktyshi reservoir, where only amateur crayfish fishing is noted. Intensive fishing increases the mortality of females, whose annual survival rate is 37 %, while in the absence of fishing, the survival of females increases up to 57 %. The annual survival rate of males is 41–49 %. The fishing pressure leads to decrease in the survival rate of individuals and disappearance of crayfish aged 9–10 years from the population.
The interaction of endogenous and exogenous factors in the biological rhythms of the Arabesque greenling Pleurogrammus azonus in the Primorie waters
Authors: Vdovin A. N. , Chetyrbotsky A. N. , Izmyatinsky D. V.
Published: July 2023

Arabesque greenling Pleurogrammus azonus is an important commercial species in the waters of Russia and Japan. In the Russian waters of the Japan Sea, regular study of its biology was conducted in the waters of the Primorsky Krai, where annual trawl surveys were performed. Material collections covered the entire calendar year. Endogenous rhythms (internal biological clocks) play a crucial role in the coordination of biorhythms of the Arabesque greenling Pleurogrammus azonus. This assumption is confirmed by the different duration of exogenous and endogenous rhythms: the dynamics of the temperature index has a pronounced periodization equal to one astronomical year, and the duration of the mixed rhythms in the dynamics of physiological processes and main components changes with age. The relationship of somatic and generative growth with temperature oscillation is subjected to age-related variability. In juveniles, this relationship is not clearly traceable. At the beginning of puberty period, significant connections are manifested. Then the dependence of growth indicators on the temperature oscillation is reduced, as the selective ability of the Arabesque greenling to choose the temperature range increases. Selective ability to environmental conditions is largely determined not by individual but by group behavior.
Latest observations on the low energy excess in CRESST-III
Authors: Angloher G. , Banik S. , Benato Giovanni , Bento A. , Bertolini Andrea , Breier Robert , Bucci Carlo , Canonica Lucia , D'Addabbo Antonio , Di Lorenzo S. , Einfalt Leonie , Erb Anna , von Feilitzsch F. , Ferreiro Iachellini Nahuel , Fichtinger S. , Fuchs Dominik , Fuss Alexander , Garai Abhijit , Ghete V. M. , Gerster S. , Gorla Paolo , Guillaumon P. V. , Gupta S. , Hauff D. , Ješkovský Miroslav , Jochum Josef , Kaznacheeva Margarita , Kinast Angelina , Kluck Holger , Kraus Hans , Langenkämper Alexander , Mancuso Michele , Marini Laura , Meyer L. , Mokina Valentyna , Nilima Athoy , Olmi M. , Ortmann T. , Pagliarone Carmine Elvezio , Pattavina Luca , Petricca Federica , Potzel Walter , Povinec Pavel , Pröbst F. , Pucci F. , Reindl Florian , Rothe Johannes , Schäffner Karoline , Schieck Jochen , Schmiedmayer D. , Schönert S. , Schwertner C. , Stahlberg Martin , Stodolsky Leo , Strandhagen Christian , Strauss R. , Usherov I. , Wagner F. , Willers Michael , Zema Vanessa
Published: July 2023

The CRESST experiment observes an unexplained excess of events at low energies. In the current CRESST-III data-taking campaign we are operating detector modules with different designs to narrow down the possible explanations. In this work, we show first observations of the ongoing measurement, focusing on the comparison of time, energy and temperature dependence of the excess in several detectors. These exclude dark matter, radioactive backgrounds and intrinsic sources related to the crystal bulk as a major contribution.
The DAMIC-M experiment: Status and first results
Authors: Arnquist Isaac J. , Avalos N. , Bailly P. , Baxter David , Bertou Xavier , Bogdan Mircea , Bourgeois Christian , Brandt J. , Cadiou Arnaud , Castelló-Mor Nuria , Chavarria Alvaro E. , Conde Marcel , Corso Nicholas J. , Gutiérrez J. C. , Cuevas-Zepeda Julian , Dastgheibi-Fard A. , De Dominicis Claudia , Deligny Olivier , Desani R. , Dhellot Marc , Dormard Jean-Jacques , Duarte-Campderros Jordi , Estrada E. , Florin D. , Gadola N. , Gaïor R. , González Sánchez J. , Hossbach Todd W. , Huehn Michael , Khalil Latifa , Kilminster B. , Lantero-Barreda Agustin , Lawson Ian , Lebbolo Hervé , Lee Steven , Leray Pascal , Letessier-Selvon Antoine , Loaiza Pia , Lopez-Virto Amparo , Martin David , Matalon Ariel , McGuire Kellie , Milleto T. , Mitra P. , Martin David M. , Munagavalasa Sravan , Norcini Danielle , Overman C. T. , Papadopoulos George , Paul S. , Peterson David , Piers Alexander , Pochon Olivier , Privitera P. , Ramanathan K. , Reynet Denis , Robmann Peter , Roehnelt Ryan , Settimo Mariangela , Smida Radomir , Stillwell Ben , Thomas Ryan , Traina M. , Vallerand Philippe , Van Wechel Tim , Vila Ivan , Cortabitarte Rocio V. , Vollhardt Achim , Warot Guillaume , Wolf D. , Yajur Rachana , Zopounidis J-P.
Published: July 2023

The DAMIC-M (DArk Matter In CCDs at Modane) experiment employs thick, fully depleted silicon charged-coupled devices (CCDs) to search for dark matter particles with a target exposure of 1 kg-year. A novel skipper readout implemented in the CCDs provides single electron resolution through multiple non-destructive measurements of the individual pixel charge, pushing the detection threshold to the eV-scale. DAMIC-M will advance by several orders of magnitude the exploration of the dark matter particle hypothesis, in particular of candidates pertaining to the so-called “hidden sector.” A prototype, the Low Background Chamber (LBC), with 20g of low background Skipper CCDs, has been recently installed at Laboratoire Souterrain de Modane and is currently taking data. We will report the status of the DAMIC-M experiment and first results obtained with LBC commissioning data.
Measurement of low-energy Compton and neutron scattering in Si CCDs for dark matter searches
Authors: Smida Radomir
Published: July 2023

For optimal sensitivity to low-mass dark matter candidates experiments like DAMIC-M employ skipper charged-coupled devices (CCDs) with detection threshold of just a few ionization charges. Ionization signals from small-angle Compton scatters of environmental \gammaγ-rays, an important component of the background in dark matter searches, must thus be characterized down to OO(10 eV) energy. Using a ^{241}241Am \gammaγ-ray source, we report a precise measurement of scattering on Si atomic shell electrons in a skipper CCD with single-electron resolution. Notable differences are observed between data and theoretical expectations in the L-shell energy region (<150 eV). We also present preliminary data from a skipper CCD exposed to low-energy neutrons (<24 keV) from a ^{124}124Sb^99Be photoneutron source, demonstrating a measurement of the nuclear recoil ionization efficiency in Si down to few ionization charges.
Neutron production in ($\alpha$,n) reactions in SOURCES4
Authors: Kudryavtsev Vitaly A. , Krawczun Piotr , Bocheva Rayna
Published: July 2023

Neutrons produced in spontaneous fission and (\alpha,nα,n) reactions can induce background events in underground experiments looking for rare processes. A number of computer codes are available to calculate cross-sections of (\alpha,nα,n) reactions, branching ratios to various states and neutron yields. SOURCES4 code has been used in this work to calculate neutron yields and energy spectra with input cross-sections and branching ratios taken from experimental data and models from EMPIRE2.19/3.2.3 and TALYS1.9 codes. A comparison of SOURCES4 calculations with experimental data from alpha beams and radioactive decay chains is presented.
Anisotropic ionization threshold and directional sensitivity in solid state DM detectors
Authors: Heikinheimo Matti , Sassi Sebastian , Tuominen Kimmo , Nordlund Kai , Mirabolfathi Nader
Published: July 2023

The threshold displacement energy for nuclear recoils depends strongly on the direction of the recoiling nucleus with respect to the crystal lattice. Assuming that similar dependence holds for the ionization threshold for low energy nuclear recoils, we explore the consequences of the resulting directional dependence of the observable event rate in ionization detectors. For low mass dark matter, this effect leads to a daily modulation in the event rate. We discuss how this effect can be utilized to separate the DM signal from the solar neutrino background and how the structure of the modulation signal can be used to identify the type of the DM-nucleon coupling.
Transindividual Equations/Matrices
Authors: Porter Zander
Published: July 2023

This writing (thinking-feeling) unfolds (an articulation of) contemporary (dis)embodiment through specified glances at the "(post-)internet,” schizoid relationality, and network/device/identity matrices. Technogenetic (and hormonal) play and transductions for transindividuality on the transparency-obfuscation (or personality/anonymity) binaries arrive as psychotherapeutics for symphonic moving-sensing-feeling-thinking-communicating in a potentiated post-neoliberal matrix (networking). Generated is a set of direction-possibilities for a post-internet-bodied world consumed by a hegemony of individualizations and self-captures, desiring instead towards queerer ceremonies and telepathic forms of (care-)presence/therapy for being-together-alone (individuation). The concurrent/included choreographic and research-artistic work 3M0T1NG{n3tw0rk1ng} peeks into a technogenetic xeno-spacetime containing relating (meta-)selves.
Spur Pruning Leaving One Bud is an Interesting Viticultural Strategy to Control Bud Acrotony in Bolivian Vineyards
Authors: Gutiérrez-Gamboa G. , Pinedo X. , Villena W. , Araya-Alman M. , Pszczólkowski P.
Published: July 2023

Bolivian viticulture is mostly found in the Central Valley of Tarija, which is characterised by a subtropical climate with high thermal oscillation in winter that results in low accumulation of chilling units. Such climatic conditions accentuate acrotony in vines, which affect budburst uniformity and, consequently, yield and bunch quality at harvest. The aim of this study was to evaluate the effect of different spur pruning strategies on the percentage of budburst and fertility of buds located in different nodal positions in both wine and table grape varieties growing in the Central Valley of Tarija. The results show that allocating spurs with fewer buds improved the budding of most of the distal buds studied. This was noted in both the wine and table grape cultivars, but mostly in the latter. Spur pruning leaving one bud improved the percentage of budburst and the fertility of the distal buds in Cabernet Sauvignon, Cardinal and Ribier, thereby preventing bud acrotony, compared to spur pruning leaving two buds. Spur pruning leaving two buds improved the budburst of latent buds in Cabernet Sauvignon. Therefore, to avoid acrotony patterns, viticulturists should perform pruning leaving one bud.
UNIDADES TEMÁTICAS: POSSIBILIDADES PARA O DESENVOLVIMENTO DOS PRINCÍPIOS DA EDUCAÇÃO AMBIENTAL CRÍTICA
Authors: Ponzoni Aline , Slaviero André , Passos Camila , Sirtori Carla
Published: July 2023

THEMATIC UNITS: POSSIBILITIES FOR THE DEVELOPMENT OF THE PRINCIPLES OF CRITICAL ENVIRONMENTAL EDUCATION. This work qualitatively analyzes the productions resulting from an extension course, developed with 24 teachers in initial and continuing training. This course was constituted by the (re)construction of knowledge related to Environmental Education (EE), in its critical aspect, to promote the debate on socio-environmental problems, allied to the theme of perfluorinated compounds, as a way of inserting these discussions in basic education, through the construction of teaching materials in the format of Thematic Units (TU). Thus, the objective of this study is to analyze the four TU produced by the course participants, in order to classify such productions supported by indicators and parameters of critical environmental education. Thus, it was possible to observe that most productions significantly contemplated these indicators, demonstrating that the activities and discussions developed enabled teachers to build a critical view of socio-environmental issues and perceptions of the possibility of developing them in the school environment.
Concepts and Principles of Da'wah in The Frame of Islamic Community Development
Authors: Ibrahim Malik , Riyadi Agus
Published: July 2023

This study aims to analyze how the concepts and principles of da'wah develop Islamic society. This research uses a type of qualitative research with a literature approach and with literature study methods. The study results show that the concept of da'wah for empowering the Islamic community prioritizes the example and ethics of a preacher. Besides that, it focuses more on da'wah with a series of activities that can improve people's welfare regarding economy, development, and technology. Meanwhile, the principle of community development da'wah uses the tenets of ukhuwwah, Ta'awun, justice, participation, and equality.
Community Participation in Development of Batik Villages through The Walet Sakti Kebumen Association
Authors: Mufid Abdul , Ulya Helina Himmatul
Published: July 2023

Succsesfull development of the Kebumen batik village in Gemesekti Village requires the participation of batik craftsmen. The potential of Kebumen batik can improve the people's economy. This is proven in the program carried out by the Walet Sakti Association. Paguyuban Walet Sakti is one of the organizations that is intense in improving people's welfare through Kebumen batik. This study aims to determine the process of increasing community participation in the development of batik villages through the Kebumen Walet Sakti Association. This study uses a type of qualitative research with data collection techniques in the form of observation, interviews, and documentation. The results of this study are: first, the process of increasing community participation in the development of batik villages through the Kebumen Walet Sakti Association in Gemsekti Village, Kebumen District, Kebumen Regency as follows: Assessment of Problems (Assessment), Program Planning, Program Implementation, and Evaluation. As for internal supporting factors such as getting support from the Kebumen Regional Government, vision and mission compatibility, high participation, Kebumen batik has branding, and has good relationships between members. The inhibiting external factors are: the lack of marketing knowledge of batik craftsmen through social media. there are fears that batik craftsmen have about product marketing, inadequate quality and quantity of human resources. hard to get raw materials. Entrepreneurial spirit of batik craftsmen is still low.
Relationship of Social Capital and Collective Action in The Development of Tourism Village
Authors: Suryandhani Allifia Rizqi , Prayitno Gunawan , Surjono Surjono
Published: July 2023

The development of a tourist village focuses on the active involvement of the local community and is inseparable from the ties of social capital they have. Social capital is a picture of social life in which participants carry out joint actions effectively to achieve common goals. However, Gunungsari Village has yet to realize its social capital by utilizing collective effort to build and develop village potential, so the whole community cannot enjoy the development of Gunungsari Village into a tourism village. This study aims to identify what indicators form social capital variables and the relationship between social capital variables and collective action in developing tourism villages. This quantitative study uses structural equation model analysis to determine the relationship between variables. Based on the findings, it is known that social networks in forming social capital are 0.445. Furthermore, social capital comprises a community action of 0.950. Therefore, networking in social capital at all levels of society is one of the primary keys to the smooth implementation of development.
Hydrochemical evaluation of spring's water in Mila Wilaya, North-East Algeria
Authors: Lynda Chebbah , Abdesselem Kabour
Published: July 2023

Springs are natural outflows of groundwater to the surface, enabling to understand the processes of their mineralization; contact with rocks modifies their chemical composition, a combination that is expressed in hydrochemical facies, which are classified into several types. Knowledge of the spatial distribution and chemical composition of spring waters is essential for a good understanding of the hydrodynamisms and hydrogeology of a given region. The mountains bordering the town of Mila are home to a number of groundwater springs, 25 of which are the subject of this study. They were sampled, then analysed at the ADE Mila (Algerian Water Company) laboratory in 2021, and their hydrochemical properties were determined. Geologically, the area hosting these springs belongs to the Tellian domain, the eastern segment of the Maghreb chain, which represents the alpine range of North Africa. Comparison of the water quality of these springs with Algerian and WHO (World Health Organization) drinkable standards has enabled most samples to be classified as soft or moderately hard water, with the dominant facies HCO3-–Ca2+–Mg2+ and Cl−–SO42-–Ca2+–Mg2+. In these waters, the main factors controlling hydrochemical composition are water–rock interactions, and rainwater contribution.
Remote sensing and GIS-based watershed prioritization for land and water conservation planning and management
Authors: Singh Mahesh Chand , Satpute Sanjay , Prasad Vishnu
Published: July 2023

Identifying the most critical sub-watershed or reservoir catchment in relation to water spread, pattern of soil erosion and aquifer recharge in a basin can be highly useful for implementing conservation measures. Thus, a study was undertaken to (i) review the various parameters used in watershed morphometric analysis with their appropriate mathematical expressions, (ii) discuss their importance in watershed prioritization and conservation planning, (iii) formulate mathematical relationship between important morphometric parameters, and (iv) discuss the different tools and techniques used for sub-watershed prioritization. All the morphometric parameters are important for hydrologic characterization and watershed prioritization. However, some of them are highly significant for better understanding of the watershed drainage network, geometry, drainage texture and relief parameters. The smaller values of shape parameters viz. form factor (Ff < 0.78), elongation ratio (Re < 0.80) and circularity ratio (Rc < 0.50) indicate a basin having elongated shape and flatter peak for extended period and permit a greater soil erosion/loss as these are inversely related with erodibility. Whereas, the greater values of Ff (>0.78), Re (>0.80) and Rc (>0.50) indicate a basin having circular shape and higher peak for smaller period. The higher values of drainage density (Dd > 0.60), drainage texture (Dt > 0.6) and stream frequency (Fs > 10) also indicate higher erosion due to their direct relationship with erodibility. As per this review, watersheds can be prioritized by several techniques including morphometric analysis, LULC change analysis and soil loss estimation. However, the morphometric analysis-based watershed prioritization is found to be laborious and time consuming as it involves numerous parameters, and hence can be replaced by modern data reduction methods like principal component analysis (PCA) using suitable software's like R, SPSS and XLSTAT. Thus, geospatial techniques-based catchment/watershed prioritization supported with an appropriate data dimension reduction technique (e.g. PCA) would be highly significant for planning conservation measures and management in a watershed.'
Sistema de simulación numérica para la costa de Chile central mediante el acoplamiento de modelos numéricos
Authors: Bahamóndez Sergio , Aguirre Catalina
Published: July 2023

Con la modelación numérica es posible anticipar condiciones de oleaje desfavorables para la actividad portuaria. Mediante modelos numéricos acoplados es factible incluir una mayor cantidad de variables, parámetros, procesos e interacciones con el objetivo de mejorar la representación y precisión de lo que ocurre en la realidad. En este trabajo se presenta un sistema de simulación numérica para la costa de Chile central mediante el acoplamiento del modelo de oleaje Wavewatch III (WW3) con el modelo hidrodinámico Coastal and Regional Ocean Community (CROCO) y el modelo atmosférico Weather Research and Forecasting (WRF). El sistema de modelación considera un acoplamiento unidireccional desde las variables de WRF que utilizan como entrada CROCO y WW3, además de un acoplamiento bidireccional entre los modelos CROCO y WW3. Este último se desarrolla a través de la implementación del software acoplador Ocean Atmosphere Sea Ice Soil (OASIS-MCT3) y el uso de las herramientas de acoplamiento facilitadas por CROCO. Los resultados son contrastados con observaciones instrumentales de oleaje realizadas por el Centro Nacional de Datos Hidrográficos y Oceanográficos de Chile (CENDHOC) a través de estadígrafos como el sesgo, error cuadrático medio y correlación. Las simulaciones acopladas hidrodinámicamente presentan un mejor grado de ajuste a las mediciones en comparación con las sin acoplamiento. En este sentido, los estadígrafos revelan un menor sesgo para las alturas significativas y direcciones medias acopladas. Asimismo, se obtienen mayores valores en los coeficientes de correlación de la altura de oleaje con acoplamiento hidrodinámico.
Diseño por vida útil de infraestructura marítima en hormigón armado: enfoque holístico con experiencias de casos chilenos
Authors: Ebensperger Luis
Published: July 2023

La consideración de la vida útil del hormigón armado en las distintas etapas del ciclo de vida de una estructura, como un elemento diferenciador al momento de proceder con el diseño por desempeño asociado a las condiciones de agresividad del ambiente en que ésta se ubique, ha generado nuevos desafíos constructivos. Junto al desarrollo de nuevas normativas que incluyen materiales innovadores de ingeniería, la incorporación de ensayos de desempeño y a procesos de modelamiento para la estimación del desarrollo del deterioro del hormigón en el tiempo, y a procesos constructivos que aseguren un adecuado Control de Calidad y Aseguramiento de la Calidad QAQC. Lo anterior ha llevado a obras de infraestructura que incluso podrían sobrepasar su período de uso manteniendo niveles de serviciabilidad por más de 100 años. Tal es el caso, por ejemplo, del proyecto del puente Chacao, actualmente en ejecución, en el sur de Chile. En este trabajo se revisan las distintas etapas de un proyecto considerando un enfoque holístico, concentrándose en aquellos aspectos que debieran considerarse inherentes a toda planificación, incluyendo complementariamente al proceso de diseño y constructivo, las etapas de control de los niveles de deterioro a través de diagnósticos con una frecuencia determinada, y monitoreos si fuera pertinente, para apoyar en todo momento la Gestión del Estado de Salud de la estructura. Se presentan algunos casos de diseño de casos reales efectuados con modelos creados para cada caso.
Solid State & Microelectronics Technology
Authors: Roy Sunipa , Kumar Ghosh Chandan , Dey Sayan , Kumar Pal Abhijit
Published: July 2023

Solid State & Microelectronics Technology is a comprehensive textbook designed for courses in solid state device physics as part of electronics / electrical engineering and IT courses. The book has two main objectives aimed at students and the future engineer: 1) to deliver knowledge of quantum physics and 2) to familiarize them with modern device types and fabrication processes. The breadth of subjects covered in the book serves a useful integrative function in combining fundamental science with applications. Recent developments are illustrated thoughtfully to encourage the reader to adopt this field as their research area.

Key features

Adopts a twin approach to learning about solid state devices by blending information about fundamental science with the latest fabrication technology

Covers topics recently introduced into current curricula to cater to the demands of modern engineering

Provides foundational information on quantum physics, semiconductors and electronics

Provides details about advanced devices such as BiCMOS, MESFET and FinFet devices

Encourages readers to pursue further research with detailed illustrations and references
Cationic Amphiphiles as Antimicrobial Agents
Authors: Dey Sarkar Sovik , Kar Chirantan
Published: July 2023

Numerous antimicrobial peptides (AMP) obtained from natural sources are
currently tested in clinical or preclinical settings for treating infections triggered by
antimicrobial-resistant bacteria. Several experiments with cyclic, linear and
diastereomeric AMPs have proved that the geometry, along with the chemical
properties of an AMP, is important for the microbiological activities of these
compounds. It is understood that the combination of the hydrophobic and hydrophilic
nature of AMPs is crucial for the adsorption and destruction of the bacterial membrane.
However, the application of AMPs in therapeutics is still limited due to their poor
pharmacokinetics, low bacteriological efficacy and overall high manufacturing costs.
To overcome these problems, a variety of newly synthesized cationic amphiphiles have
recently appeared, which imitate not only the amphiphilic nature but also the potent
antibacterial activities of the AMPs with better pharmacokinetic properties and lesser in
vitro toxicity. Thus, amphiphiles of this new genre have enough potential to deliver
several antibacterial molecules in years to come.
Amphiphilic Nanocarriers to Fight Against Pathogenic Bacteria
Authors: Sarder Amit , Mandal Chanchal
Published: July 2023

The emergence and expansion of antibiotic resistance in pathogenic bacteria
have become a global threat to both humans and animals. Immense use, overuse and
misuse of antibiotics over several decades have increased the frequencies of resistance
in pathogenic bacteria and resulted in significant medical problems. To fight against the
widespread drug-resistant pathogenic bacteria has become a terrific challenge for the
modern healthcare system. The major challenges to fight against pathogenic bacteria
involve long-term antibiotic therapy with combinations of drugs. The abundance of
resistance mechanisms in pathogenic bacteria has compelled many therapeutic
antibiotics to become ineffective. As a result, the elimination of drug-resistant
pathogenic bacteria requires a judicious strategy. The advent of nanotechnology has
unveiled a new horizon in the field of nanomedicine. Nanoparticle-based techniques
have the potential to overcome the challenges faced by traditional antimicrobials. In
this way, self-assembling amphiphilic molecules have emerged as a fascinating
technique to fight against pathogenic bacteria because of their ability to function as
nanocarriers of bactericidal agents and interact and disrupt bacterial membranes.
Nanocarrier-based drug delivery systems can mitigate toxicity issues and the adverse
effects of high antibiotic doses. The focus of this chapter is to discuss various
amphiphilic nanocarriers and their roles and possibilities in fighting against pathogenic
bacteria.
Photodynamic Therapy: A Viable Alternative Strategy to Control Microbial Invasions
Authors: Pal Roy Moushree
Published: July 2023

Antimicrobial photodynamic therapy (aPDT) is a new-age therapeutic
technique that by principle, focuses on the eradication of target cells by highly
cytotoxic reactive oxygen species (ROS) generated through the activation of a chemical
photosensitizer (PS) molecule with visible light of appropriate wavelength. The
cytotoxic species can arise via two main mechanisms known as Type I and Type II
photoreactions: the former leads to the generation of ROS and the latter to the
formation of the singlet oxygen. These highly reactive oxidants can bring about
instantaneous oxidation of a great array of biological molecules, causing havoc to the
target cell. This technique provides significant advantages over conventional
antimicrobial therapies in practice which are now facing the burning threat of growing
complete resistance against them. To combat this world-wide health concern, new
treatment strategies are the need of the time while ensuring no further rise of resistance
against those alternative therapies, and aPDT appears to be highly promising in this
aspect by fulfilling all the demands at the same time. It appears not only equally
effective at killing both antibiotic-sensitive and multi-resistant bacterial strains, but also
highly selective, non-invasive and rapid in action than other antimicrobial agents, and
there have been no reports of resistance till date. The success of this phototherapy relies
on several factors, including the target cell type, reaction conditions, and the type,
molecular structure and cytolocalization of the PS; because its potency depends on the
distribution, high reactivity and short lifetime of ROS as well as the PS itself in
electronically excited states.
Probiotics-based Anticancer Immunity In Oral And Oropharyngeal Cancer
Authors: Kumari Bindu , Kumar Singh Gireesh , Sinha Sonal , Kumar Singh Dhananjay
Published: July 2023

Oral and Oropharyngeal cancer constitute severe community health
problems across the globe. Annually about 400,000 new cases of oral cancer are
detected globally. Oral cancer is the sixth most common type of cancer in the world,
and it is the leading cause of death, particularly in the Southeast Asian region. In recent
times, a gradual surge in cases of oral cancer has been witnessed in many developed
countries, such as France. In the search for safe and effective therapy for cancer,
probiotics have gained recent attention from many research groups worldwide.
Probiotics have an advantageous effect on human health, which are experimentally and
clinically proven to exert overall beneficial effects. Probiotics are generally defined as
the sum of harmless live bacteria, molds, and yeasts that have beneficial effects on
human health. This chapter discusses the potential role of probiotics as anticancer
adjuvants owing to their modulatory effect on anticancer immunity. Anticancer
immunity-based properties include the restraint of the growth of microbiota engaged in
the making of mutagens and carcinogens and change in the metabolism of carcinogen
and DNA resistance from oxidative damage as well as regulation of the immune
system. At present, chemotherapy and immunotherapy are mostly preferred for the
treatment of oral cancer, but these treatments have the foremost disadvantage that
causes drug resistance and recurrence of the disease. To overcome such problems,
nowadays, probiotics have been recommended as complementary treatment modalities
for the development of new therapy along with standard chemotherapeutic and
immunotherapeutic agents by improving the immune system. Specific microbiota in the
human body supplies the production of the most useful metabolites that exert optimistic
properties on the immune system in opposition to various diseases such as cancer.
A prática pedagógica reflexiva em questão: Estudo de caso de uma escola brasileira
Authors: De Oliveira Terezinha Marisa Ribeiro , Amaral Luiz Henrique , Amaral Carmem Lúcia Costa
Published: July 2023

No Brasil, a teoria do professor reflexivo vem sendo alvo de discussão em cursos de formação continuada e nos documentos oficiais orientadores de formação inicial. Entretanto, será que os professores desenvolvem uma prática reflexiva, ou essa prática fica só nas orientações documentais? Com o objetivo de responder a esse questionamento, realizamos uma pesquisa com quinze professores de uma escola pública localizada no estado de São Paulo, Brasil. Para essa pesquisa, baseamo-nos em três questões propostas por McKay (2008). Essas questões versaram sobre o planejamento das atividades pedagógicas, em que se baseavam para avaliar as suas aulas e em que momento refletiam sobre sua prática. Os resultados evidenciaram que a maioria segue o currículo do estado de São Paulo, e as reações dos alunos foram o parâmetro mais utilizado para a avaliação das aulas ministradas, nas quais os professores desenvolvem principalmente a reflexão na ação. Com essa pesquisa percebemos que para esse grupo de professores, torna-se importante um aprofundamento da reflexão sobre as suas práticas.
Using Liquid Biopsy to Predict Relapse After Radiotherapy in Squamous Cell Head-Neck and Esophageal Cancer
Authors: KOUKOURAKIS IOANNIS M. , XANTHOPOULOU ERASMIA , KOUKOURAKIS MICHAEL I.
Published: July 2023

Circulating cell-free DNA (cfDNA) in the blood of cancer patients contains tumor-specific mutated genes and viral genome that can be identified and quantified as ‘tumor-specific cfDNA’ (circulating tumor DNA, ctDNA). Various technologies are available that offer reliable detection of ctDNA at a low concentration. Quantitative and qualitative analysis of ctDNA may be of prognostic and predictive value in oncology. Here, we present concisely the experience on the assessment of ctDNA levels and kinetics during therapy in the outcome of radiotherapy (RT) and chemo-radiotherapy (CRT) in squamous cell head-neck cancer and esophageal squamous cell cancer patients. The levels of circulating viral (human papilloma virus or Epstein-Barr) ctDNA, and levels of total, mutated or methylated ctDNA at diagnosis are linked with tumor burden and clinical aggressiveness, and may be of prognostic or even predictive value of RT/CRT efficacy. Persistent ctDNA levels after therapy seem to predict high rates of tumor relapse several months before radiological documentation. This can prove of value for the identification of subgroups of patients who could benefit from RT dose-escalation or consolidation chemotherapy and immunotherapy, a hypothesis that should be tested in clinical trials.