bluuebunny/crossref_metadata_2025 huggingface dataset:
“Anything Can Happen at Any Time”: Perceived Causes of Correctional Officer Injuries
Authors: Goulette Natalie , Denney Andrew S. , Crow Matthew S. , Ferdik Frank V.
Published: August 2020

Prior research finds that correctional officers (COs) often report high levels of stress, poor mental and physical health and are at an increased risk of suffering work-related injuries. However, little is known about the causes of such injuries. In an attempt to fill this large gap in the literature, the current study used qualitative data to explore the perceived causes of work-related injuries according to COs and their executive staff. Officers identified the reasons for injuries as either within their control or outside of their control. Injuries resulting from factors within CO’s control were perceived to be related to complacency and corruption. Injuries stemming from circumstances outside of CO’s control were perceived to be related to the nature of the job, the mental health of inmates, minor events escalating, and what are known as inmate “check-ins.” In consideration of these findings, policy implications and directions for future research are also reviewed.
The Role of Internet-Specific Justification Beliefs in Source Evaluation and Corroboration During Web Search on an Unsettled Socio-Scientific Issue
Authors: Kammerer Yvonne , Gottschling Steffen , Bråten Ivar
Published: August 2020

This study explored relationships between Internet-specific justification beliefs and source evaluation and corroboration during Web search. Fifty university students completed the Internet-Specific Epistemic Justification Inventory (ISEJ), which targeted beliefs concerning the justification of Internet-based knowledge claims about natural science issues. Two to five days later, they conducted a Web search in order to communicate a justified position regarding an unsettled and unfamiliar socio-scientific issue. Using think-aloud and trace methodologies, participants’ source evaluation and corroboration behaviors were examined. Furthermore, the extent and relevance of their post-search written justifications for their recommendation about the controversial issue were analyzed. Results showed that beliefs in justification by authority positively predicted comments regarding source evaluation, the percentage of visited websites that were listed beyond the first three Google search results, and the likelihood of opening multiple browser tabs. Beliefs in personal justification negatively predicted comments regarding corroboration of information across websites and the number of relevant aspects included in the written justifications. Finally, participants with stronger beliefs in justification by multiple sources gave more extensive justifications for their recommendation and included more relevant aspects in those justifications.
Volunteering among Older Lesbian and Gay Adults: Associations with Mental, Physical and Social Well-Being
Authors: Lyons Anthony , Alba Beatrice , Waling Andrea , Minichiello Victor , Hughes Mark , Fredriksen-Goldsen Karen I. , Edmonds Samantha , Blanchard Michelle , Irlam Corey
Published: August 2020

Objectives: Volunteering is associated with positive well-being among older people, providing opportunities to stay active and socially connected. This may be especially relevant for older lesbian and gay people, who are less likely than heterosexual people to have a partner, children or support from their family of origin. Methods: Patterns of volunteering and mental, physical and social well-being were examined in a sample of 754 lesbian and gay adults in Australia aged 60 years and older who completed a nationwide survey. Results: Volunteers reported greater positive mental health than non-volunteers. Among the gay men, volunteers additionally reported higher self-rated health and social support and lower psychological distress. Both the lesbian women and gay men who volunteered for lesbian, gay, bisexual, transgender or intersex (LGBTI) organisations also reported greater LGBTI community connectedness than volunteers for non-LGBTI organisations. Discussion: These findings provide further insight into potential factors associated with the well-being of older lesbian and gay adults.
Gender Wage Gap and the Involvement of Partners in Household Work
Authors: Matteazzi Eleonora , Scherer Stefani
Published: August 2020

Women still earn less than men and continue to perform the bulk of domestic activities. Several studies documented a negative individual wage–housework relation, suggesting that gender discrepancies in housework may explain the gender wage gap. Less attention has been paid to the role of the partner’s unpaid work and to the extent that intra-household inequalities relate to inequalities outside the house. The present study attempts to fill this gap in the literature. We exploit EU-SILC 2010 data for Germany and Italy and PSID 2009 data for the US. Results suggest the importance of accounting for a partner’s housework when evaluating the determinants of individual wages and the gender wage gap. Women seem not to profit from their partners’ housework; instead, women’s non-market work increases their partners’ earnings while decreasing their own earnings. This suggests the importance of reducing women’s involvement in domestic work in order to close gender wage equalities.
A new hysteresis model for magneto–rheological dampers based on Magic Formula
Authors: Bui Quoc–Duy , Nguyen Quoc Hung , Bai Xian–Xu ‘Frank’ , Mai Duc–Dai
Published: August 2020

This paper investigates a novel model based on the Magic Formula and the Pan’s model to effectively predict the inherent nonlinear hysteresis behavior of magneto–rheological (MR) dampers. In the proposed model, the hysteresis element is employed from the Magic Formula and Pan’s model, and two new independent horizontal shift parameters, which are separated from one original parameter of the Pan’s model, are added. Each of them characterizes an offset with respect to the origin for each branch of hysteresis curves, providing more flexibility and effectiveness for simulating curves with high asymmetry. In addition, a parameter to further control the sharpness of hysteresis curves in the backward region of damping force–velocity is proposed, which is useful to simulate the behavior of MR dampers in rather extreme operating cases. A case study is performed on a prototype MR damper for washing machines, in which the model incorporates applied current and excitation frequency as variables to make it more adaptable to a wide range of working conditions. For comparison, performance of three hysteresis models, including the Spencer’s model, the Pan’s model and the proposed model, are analyzed and evaluated. The research results show that, as compared with the others, the proposed model can not only predict the nonlinear hysteresis behavior of MR dampers more precisely, but is also more compatible with different operating excitations, and the clearer meanings of the model parameters make them easier to study and identify.
Design and energy utilization of electro-hydrostatic hydraulic hybrid system for battery bus
Authors: Chen Guanpeng , Liu Huanlong
Published: August 2020

In order to solve the problems of large peak torque and short battery life when the city battery bus starts or accelerates, a new electro-hydrostatic hydraulic hybrid powertrain is designed in this paper that can operate efficiently in all speed conditions with a certain type of electric bus running in Chengdu. The improvement of comprehensive energy efficiency of power system by switching between different power modes under typical operating conditions is studied. Through the co-simulation of AMESim and MATLAB/Simulink-stateflow software, the vehicle and control models are established and the rule-based dynamic optimal energy management strategy is set. The dynamic performance and energy utilization characteristics of New European Driving Cycle and the cycle condition of investigation under actual driving environments are analyzed. The core problems of energy coupling of electro-hydrostatic hydraulic hybrid powertrain are studied experimentally to verify the correctness of the design thought and simulation model. The results show that under the premise of satisfying the dynamic performance, the designed electro-hydrostatic hydraulic hybrid system can effectively improve the overall average efficiency of operating point of the electric motor and greatly reduce the peak torque. The peak torque is reduced by 36.4% and the battery power consumed by the selected cycle is reduced by 33.98% under New European Driving Cycle conditions. Under the actual cycle conditions, the peak torque is reduced by 28.9%, and the battery power consumed by the selected cycle is reduced by 32.3%.
A business model and cost analysis of automated platoon vehicles assisted by the Internet of things
Authors: Chen Junyan , Chen Haibo , Gao Jianbing , Pattinson Jo-Ann , Quaranta Romina
Published: August 2020

Platoon services are being driven by the development of Internet of things, prompting changes in existing businesses and the generation of new businesses. In this paper, a business model and business model canvas related to platoon services are proposed, and the cost analysis of heavy freight transport platoon services from the perspective of platoon leaders and followers is conducted. In addition, the fuel consumption saving brought about by platoon services in freight transport of 28 European Union countries is estimated. The results indicate that the providers of the autonomous driving package, Internet of things devices and the platoon service platform are new stakeholders in the business model. The business model canvas shows the value propositions of platoon services, such as increased traffic efficiency, decreased energy consumption, and the opportunity of involvement in other activities. In addition, the analysis of cost structures for platoon leaders and followers shows that the autonomous driving package has the highest percentage of cost in the first year of a vehicle’s lifespan and decreases rapidly in the years that follow. The platoon services ease the financial burden of the leaders due to decreased fuel consumption and income from the leading service, with the highest value up to 4.7%. As for the fuel consumption reductions benefited from platoon services, Germany may have the largest potential of national annual fuel saving, followed by France, Spain and the United Kingdom, while the countries that may benefit the most from fuel savings in international freight transport are Poland and Spain.
Missed opportunities: misconceptions and lack of knowledge about vulval skin care in women attending a sexual health clinic
Authors: Shaw Roberta , Masaun Kiran , Liston James , Bates Christine , Clarke Emily
Published: August 2020

Vulval skin care is an important part of women’s health, and this evaluation aimed to explore vulval care among women attending our sexual health clinic. A questionnaire was completed by 135 women over a five-week period. Forty-three women (32%) washed their vulva two to three times a day, with 93 (69%) using a detergent-containing product. Thirty-eight women (28%) used sanitary products when not menstruating. Ninety-five women (70%) reported at least one previous vulvo-vaginal condition. One hundred and two women (76%) reported being confident in vulval care; however, 60 women (44%) wished to receive more information. The mismatch between women’s confidence and knowledge may reflect mixed sources of education used by women. We recommend that sexual health clinics review the information they provide to patients on vulval care.
The ultra-high efficiency gas turbine engine, UHEGT, part I: Design and numerical analysis of the multistage system
Authors: Ghoreyshi Seyed M , Schobeiri Meinhard T
Published: August 2020

The Ultra-High Efficiency Gas Turbine Engine (UHEGT) was introduced in our previous studies. In UHEGT, the combustion process is no longer contained in isolation between the compressor and turbine. It is rather distributed in multiple stages and integrated within the high-pressure turbine stator rows. Compared to the current most advanced conventional gas turbines, UHEGT considerably improves the efficiency and output power of the engine while reducing its emissions and size. In this study, a six-stage UHEGT turbine with three stages of stator internal combustion is designed and analyzed. The design represents a single spool turboshaft system for power generation using gaseous fuels. The preliminary flow path for each turbine stage is designed by the meanline approach and modified using Computational Fluid Dynamics (CFD). Unsteady CFD calculation (via commercial software ANSYS CFX) is used to simulate and optimize the flow and combustion process through high-pressure turbine stages. The results show a base thermal efficiency of above 45% is achieved. It shows a successful integration of the multi-stage combustion process into the high-pressure turbine stages and a highly uniform temperature distribution at the inlet of each rotor row. High temperatures in some areas on the stator blade surfaces are controlled using indexing of fuel injectors and stator blades.
MDM2 inhibition improves cisplatin-induced renal injury in mice via inactivation of Notch/hes1 signaling pathway
Authors: Luo X , Zhang L , Han G-D , Lu P , Zhang Y
Published: August 2020

Objective:

To explore the potential function of MDM2-mediated Notch/hes1 signaling pathway in cisplatin-induced renal injury.

Methods:

The acute renal injury models of mice after intraperitoneal injection of cisplatin in vivo, and the apoptotic models of human renal tubular epithelial (HK-2) cells induced by cisplatin in vitro, were conducted respectively. The renal function-related parameters were measured. The renal tissue pathological changes and apoptosis were observed by PAS staining and TUNEL staining, respectively. Cell viability and apoptosis were detected by MTT and flow cytometry. Notch/hes1 pathway-related proteins were tested by Western blotting.

Results:

After mice injected by cisplatin, the levels of Cr, BUN, urine cystatin C, urine NGAL and urine ACR were increased and GFR was decreased with the elevation of renal tubular injury scores, the upregulation of the expressions of MDM2, N1ICD, Hes1 and Cleaved caspase-3, as well as the enhancement of cell apoptosis accompanying decreased ratio of Bcl-2/Bax. However, these cisplatin-induced renal injuries of mice have been improved by MDM2 inhibition. Besides, the declined viability, increased cytotoxicity, and enhanced apoptosis were observed in cisplatin-induced HK-2 cells, with the activated Notch/hes1 pathway. Notably, the phenomenon was alleviated in cisplatin-induced HK-2 cells transfected with MDM2 shRNA, but was severer in those co-treated with AdMDM2. Moreover, Notch1 siRNA can reverse the injury of AdMDM2 on HK-2 cells.

Conclusion:

Inhibiting MDM2 could reduce cell apoptosis through blocking Notch/hes1 signaling pathway, thus alleviating the acute renal injury caused by cisplatin.
Assessing Commonality in Liquidity: Evidence from an Emerging Market’s Index Stocks
Authors: Kumar Gaurav , Misra Arun Kumar , Pant Abhay , Rahman Molla Ramizur
Published: August 2020

This study investigates the degree to which movements in stock liquidity is determined by common underlying factors in a large emerging market, India. This degree is called commonality. Commonality has been measured for NIFTY50 stocks using high frequency data across a variety of liquidity measures. This study empirically verifies the relative strength of market- and industry-wide liquidity in explaining commonality. Furthermore, the study analyses the impact of industry-wide liquidity on the liquidity of individual stocks belonging to the key industries of Indian economy, viz. consumer goods and pharma, energy, financial services, infrastructure, information technology (IT) and telecom, manufacturing and natural resources. Among all the sectors studied infrastructure, IT and telecom, manufacturing and natural resources sectors possess higher degree of Industry-wide commonality. This means fund managers find it difficult in altering a portfolio having greater exposure to these sectors. Studying the behaviour of commonality will also assist regulators in monitoring abnormal market fluctuations. The study contributes to the understanding of commonality on an emerging order driven market like India.
Piezoelectric energy harvesting experiments under combined aerodynamic and base excitation
Authors: Stamatellou Antiopi-Malvina , Kalfas Anestis I
Published: August 2020

The behavior of film-type piezoelectric energy harvesters under simultaneous aerodynamic and base excitation was experimentally investigated. Two flutter type piezoelectric film transducers (LDT0-028K and LDT1-028K) were excited with the 31 excitation mode. The aerodynamic excitation was produced by a centrifugal fan. The base excitation was produced by a cone speaker driven by sinusoidal voltage waveforms in the frequency range of 20 to 250 Hz. This frequency range includes the two transducers’ resonant frequencies. The voltage output of the harvesters was monitored by an oscilloscope and the base excitation was monitored with acceleration measurements. The measured output voltage signals were analyzed by Fast Fourier Transformation. The tip deflection of the piezo-films was monitored with long exposure photography. Harvesting power output was estimated by simple calculations. The results are discussed aiming to support the optimal design of vibration energy harvesting layouts with piezoelectric transducers. To this end, information was extracted about the exploitable bandwidth of piezoelectric films.
Risk Factors Associated With Bullying at School and Electronic Bullying in U.S. Adolescent Females With Asthma
Authors: McCabe Ellen M. , Strauss Shiela M.
Published: August 2020

Although adolescent females with asthma are at increased risk for bullying, relationships between bullying at school and electronic bullying and demographics, mental health issues, and substance use have not specifically been studied in these young women. The purpose of this research was to examine such relationships among adolescent females with asthma. Complex sampling software was used to extrapolate frequencies and χ2 analyses to adolescent females with asthma. In this U.S. sample of adolescent females with asthma ( n = 1,634), younger age, mental health issues, and substance use were significantly related to bullying at school and electronic bullying, while race/ethnicity and grade in school were significantly related only to bullying at school. In general, findings are consistent with previous research regarding relationships between bullying and risk factors among all U.S. adolescent females. Guidance by school nurses is needed to create effective supports for victimization reduction in this vulnerable group.
A Team-Based Collaborative Care Model for Youth With Attention-Deficit Hyperactivity Disorder in Education and Health Care Settings
Authors: Talbott Elizabeth , De Los Reyes Andres , Power Thomas J. , Michel Jeremy J. , Racz Sarah Jensen
Published: August 2020

Attention-deficit hyperactivity disorder (ADHD) is among the most commonly diagnosed disorders of children and youth. Young people receive their ADHD diagnoses and medical treatment in primary health care settings and can experience a range of behavioral and educational disabilities treated in the clinic, at home, and at school. We propose a team-based collaborative care model (TBCCM) to foster communication and collaboration among health care and education teams, embedding implementation science methods to promote and sustain evidence-based practices for youth with ADHD. Key features of the model include (a) effective leadership and teamwork within the two universal systems of education and health care, (b) use of data from multiple informants who describe and monitor student behavior within and across contexts, and (c) adoption and adaptation of evidence-based practices. We expect that these efforts to embed implementation science methods within a collaborative team structure will improve the uptake of evidence by intervention teams in the two systems, and thus optimize outcomes for children and youth with ADHD.
Relationship Between Sensory Symptoms, Mulder’s Sign, and Dynamic Ultrasonographic Findings in Morton’s Neuroma
Authors: Padua Luca , Coraci Daniele , Gatto Dario Mattia , Glorioso Davide , Lodispoto Fabio
Published: August 2020

Background:

Morton’s neuroma (MN) is often a diagnostic dilemma lacking a gold standard set of diagnostic criteria. Advanced imaging of MN is evolving including ultrasonography. The current study aimed to analyze the relationship between ultrasonographic findings and symptoms, clinical data, and operative findings in a subgroup of patients.

Methods:

We evaluated physical examination, ultrasonographic findings, symptoms, and in a subgroup, the operative findings for Morton’s neuroma. We analyzed the symptoms, the findings on physical examination, and ultrasonography data and performed a statistical correlation between them. A total of 175 patients were seen for suspected Morton’s neuroma during the last 7 years.

Results:

Neuropathic pain of the toes was reported in 63% of patients. Presence of ultrasonographic findings suggesting Morton’s neuroma was observed in 77% of cases. A mild significant relationship between neuropathic pain and positive ultrasonographic findings was observed. We found a strong correlation between ultrasonographic and clinical evaluation, but more than half with clinical negative Morton’s neuroma had positive findings at ultrasonography. In the subgroup of operatively treated patients (n = 44) surgery confirmed Morton’s neuroma in all patients who had positive ultrasonography findings.

Conclusions:

The current study suggests that the association of ultrasonographic evaluation and clinical evaluation can be very useful for the management of Morton’s neuroma. Our study could help with the development of a multiperspective approach in the diagnosis of Morton’s neuroma.

Level of Evidence:

Level II, prospective cohort survey study.
Classification and Nomenclature: Progressive Collapsing Foot Deformity
Authors: Myerson Mark S. , Thordarson David B. , Johnson Jeffrey E. , Hintermann Beat , Sangeorzan Bruce J. , Deland Jonathan T. , Schon Lew C. , Ellis Scott J. , de Cesar Netto Cesar
Published: August 2020

Recommendation:

The historical nomenclature for the adult acquired flatfoot deformity (AAFD) is confusing, at times called posterior tibial tendon dysfunction (PTTD), the adult flexible flatfoot deformity, posterior tibial tendon rupture, peritalar instability and peritalar subluxation (PTS), and progressive talipes equinovalgus. Many but not all of these deformities are associated with a rupture of the posterior tibial tendon (PTT), and some of these are associated with deformities either primarily or secondarily in the midfoot or ankle. There is similar inconsistency with the use of classification schemata for these deformities, and from the first introduced by Johnson and Strom (1989), and then modified by Myerson (1997), there have been many attempts to provide a more comprehensive classification system. However, although these newer more complete classification systems have addressed some of the anatomic variations of deformities encountered, none of the above have ever been validated. The proposed system better incorporates the most recent data and understanding of the condition and better allows for standardization of reporting. In light of this information, the consensus group proposes the adoption of the nomenclature “Progressive Collapsing Foot Deformity” (PCFD) and a new classification system aiming at summarizing recent data published on the subject and to standardize data reporting regarding this complex 3-dimensional deformity.

Level of Evidence:

Level V, consensus, expert opinion.

Consensus Statements Voted:

CONSENSUS STATEMENT ONE: We will rename the condition to Progressive Collapsing Foot Deformity (PCFD), a complex 3-dimensional deformity with varying degrees of hindfoot valgus, forefoot abduction, and midfoot varus. Delegate vote: agree, 100% (9/9); disagree, 0%; abstain, 0%. (Unanimous, strongest consensus) CONSENSUS STATEMENT TWO: Our current classification systems are incomplete or outdated. Delegate vote: agree, 100% (9/9); disagree, 0%; abstain, 0%. (Unanimous, strongest consensus) CONSENSUS STATEMENT THREE: MRI findings should be part of a new classification system. Delegate vote: agree, 33% (3/9); disagree, 67% (6/9); abstain, 0%. (Weak negative consensus) CONSENSUS STATEMENT FOUR: Weightbearing CT (WBCT) findings should be part of a new classification system. Delegate vote: agree, 56% (5/9); disagree, 44% (4/9); abstain, 0%. (Weak consensus) CONSENSUS STATEMENT FIVE: A new classification system is proposed and should be used to stage the deformity clinically and to define treatment. Delegate vote: agree, 89% (8/9); abstain, 11% (1/9). (Strong consensus)
Variation in Employment of Therapy Assistants in Skilled Nursing Facilities Based on Organizational Factors
Authors: Mroz Tracy M. , Dahal Arati , Prusynski Rachel , Skillman Susan M. , Frogner Bianca K.
Published: August 2020

Employment of therapy assistants enables skilled nursing facilities to provide more therapy services at lower costs. Yet little is known about employment of therapy assistants relative to organizational characteristics. Taking advantage of publicly available Medicare administrative data from 2016, we examined the relationships between organizational characteristics of skilled nursing facilities and employment of therapy assistants. Therapy assistants represent approximately half of the therapy workforce in skilled nursing facilities. Regression analyses indicate significantly higher percentages of therapy assistants are employed in facilities that are staffed by contract therapists, provide more therapy, have more total stays, operate in rural areas, and are located in states with certificate of need laws or moratoria. Skilled nursing facility quality was not significantly associated with employment of therapy assistants. As new payment mechanisms change incentivizes for therapy in skilled nursing facilities, employment of therapy assistants may be a cost-effective way to continue to provide services when necessary.
Development of a simple compatibility inspection method using pressure in a BD PhaSeal™ system and hazardous drug vials
Authors: Ishimaru Hiromasa , Tsuda Yasumasa , Kage Hidenori , Kawano Tomoaki , Takayama Shinji , Morimoto Yoshihito , Goto Kazumi , Watanabe Kazuhiro
Published: August 2020

Background

Many reports support the use of closed system drug transfer devices (CSTDs) to protect against exposure to hazardous drugs during their preparation. However, leakage may occur if the CSTD fails to maintain hermeticity when fitted into the vial. Our aims were to devise a measure to prevent HD exposure and to develop a test method to verify CSTD function when a BD PhaSeal™ protector is used in HD preparation.

Methods

We selected the BD PhaSeal™ System, which is the most commonly used CSTD device in Japan. The sealability of the BD PhaSeal™ protector and vial is considered to be due to the hermeticity of the protector and the rubber stopper of the vial. We constructed a protector with a damaged sealing rim and monitored the pressure fluctuation 10 times when the BD PhaSeal™ injector was connected to the pressurized vial.

Results

The reduction in pressure of the protector in the group without a damaged sealing rim was 5%, while that in the group with the damaged sealing rim was 84.9%.

Conclusion

It was suggested that leakage occurred through the gap between the protector and the rubber stopper when using a vial that was not in close contact with the sealing rim. In this study, we developed a test that can be easily used to verify the compatibility of the BD PhaSeal™ protector and a vial in the clinical setting. Thus, when new hazardous drugs are being prepared, these measures can be taken to ensure that the risk of exposure is reduced or eliminated.
Treatment of starch films with a glow discharge plasma in air and O2 at low pressure
Authors: Sheikhi Zhian , Hosseini Seyede Marzieh , Khani Mohammad Reza , Farhoodi Mehdi , Abdolmaleki Khadije , Shokri Babak , Shojaee-Aliabadi Saeedeh , Mirmoghtadaie Leila
Published: August 2020

In this study, the effect of different cold plasma treatments was investigated as a novel method for the modification of starch film properties. The films were prepared from wheat starch using a solvent casting method and then treated with air and O2 glow discharge plasma at different durations (4, 8, and 12 min). A significant increase in the hydrophilicity of the films was observed due to the formation of oxygen-containing groups after plasma treatment. Fourier transform infrared analysis illustrated a decrease in C–H groups that caused an increase in C–O and C–O–C groups in air-treated films and carbonyl groups in O2-treated films. The surface roughness of the treated films increased from 17.6 nm to 22.5 and 20.6 nm after air and O2 treatments, respectively. Plasma treatments decreased oxygen permeability of the films but no significant difference in the water vapor permeability was observed. After plasma treatment, tensile strength of films was improved due to crosslinking and etching at the surface, although elongation at break remains unchanged.
Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys
Authors: Korte Sven , Luft Jorge , von Keutz Anne , Runge Frank , Mecklenburg Lars , Wozniak Magdalena Maria , Zander Serge , Ludwig Florian Timo , Pajaziti Betina , Romeike Annette , Korytko Peter
Published: August 2020

Many potential drugs for treatment of neurodegenerative diseases, particularly antisense oligonucleotides (ASOs), are administered via lumbar intrathecal injection, because these drugs do not cross the blood–brain barrier. Intrathecal injection is a well-established method in cynomolgus monkeys, a species that is used in preclinical safety assessment when other nonrodent species cannot be used. The authors completed intrathecal ASO administration in over 30 preclinical safety studies (>1000 animals and >4500 dose administrations) during which we observed 3 cases of procedure-related spinal cord necrosis (incidence <0.1%). We describe clinical symptoms, diagnostic approaches, morphological features, and prognosis of this rare injury, and compare these findings with typical drug-related findings of ASOs dosed by intrathecal injection. The low incidence of procedure-related and dose-limiting lesions confines this analysis to a small sample set. The pattern of effects is similar across all monkeys despite differences in age, body weight, and intrathecal injection site. All 3 cases presented a combination of the following findings: blood in cerebrospinal fluid at time of injection, clinical signs that increase in severity within a day of dosing, lameness of both hind limbs, reduced muscle tone, and loss of patellar, foot grip, and/or anal reflexes. In all cases, magnetic resonance imaging (MRI) showed a linear hyperintense lesion in the lumbar spinal cord. In 2 cases, this hyperintensity was associated with evidence of spinal cord edema. We conclude that a pattern of in-life and pathology findings, including noninvasive MRI assessment, is indicative of procedure-related effects.
Ka Moʻolelo o Ka Nuha: the safety zone at the Kamehameha Schools didn’t happen by accident
Authors: Watson Bruce Kaʻimi
Published: August 2020

Written in a style inspired by Hawaiian language newspapers of the 19th century, this moʻolelo (history) seeks to tell the story of Hawaiian patriotism at the Kamehameha Schools, a school for Indigenous children founded and funded by a princess of the Hawaiian Kingdom. With Raphael Lemkin’s phases of genocide in our pocket and Lomawaima and McCarty’s Safety Zone Theory as our guide, readers will journey through the school’s correspondence, teacher meeting minutes, and Hawaiian language newspapers documenting the celebration of the holiday Lā Kūʻokoʻa, the events surrounding the 1895 Kaua Kūloko, and the experiences of the first Indigenous teacher hired by the school.
Motivations for Treatment Engagement in a Residential Substance Use Disorder Treatment Program: A Qualitative Study
Authors: Dillon Patrick J , Kedia Satish K , Isehunwa Oluwaseyi O , Sharma Manoj
Published: August 2020

Aims:

The aim of this study was to explore perspectives on motivations for treatment engagement from substance use disorder (SUD) clients in a long-term residential rehabilitation program.

Design and Methods:

A convenience sample of 30 clients who were enrolled in a year-long SUD treatment program at a residential rehabilitation facility took part in in-depth interviews. Interview transcripts were analyzed using the directed content analysis approach.

Results:

Participant accounts indicated that their treatment engagement was motivated by factors that aligned with the six primary constructs of the Health Belief Model: (i) perceived susceptibility (eg, believing that their substance use required intervention and that they were prone to relapse), (ii) perceived severity (eg, substance use negatively impacted their health and harmed their close relationships), (iii) perceived benefits (eg, opportunities for a better life, reconnecting with family members and close friends, & avoiding legal consequences), (iv) perceived barriers (eg, the length of the treatment program), (v) cues to actions (eg, decisive moments, elements of the treatment program, & faith and spirituality), and (vi) self-efficacy in remaining abstinent (eg, treatment program provided them with skills and experiences to maintain long-term sobriety).

Discussion:

Our analysis indicates that participants’ treatment engagement was linked to their beliefs regarding the severity of their substance use disorder, their treatment program’s ability to help them avoid future relapse, and their own capability to act upon the strategies and resources provided by the treatment program. A theoretical understanding of these aspects can contribute to the future planning of precision interventions.
Menopause and multiple sclerosis: Influence on prognosis and role of disease-modifying drugs and hormonal replacement therapy
Authors: Midaglia Luciana , Otero Susana , Baró Francesc , Montalban Xavier , Tintoré Mar
Published: August 2020

Background:

Sex hormones play a role in both the risk and the prognosis of multiple sclerosis (MS). Considering all stages of women’s reproductive life, data regarding the influence of menopause on MS and vice versa are scarce.

Objective:

The aim of this study was to review the evidence addressing the relationship between menopause and MS.

Methods:

A literature search through PubMed was conducted, selecting studies that assessed (1) the influence of menopause in the MS course, (2) the influence of MS and disease-modifying drugs (DMD) on the development of menopause and (3) the effect of hormone replacement therapy (HRT) on symptoms of menopausal MS patients.

Results:

(1) Most studies suggest menopause may transitorily aggravate MS symptoms. Two studies found an inflexion point on the Expanding Disability Status Scale (EDSS) with clinical worsening during the menopausal transition. Another study considering full EDSS trajectories from clinically isolated syndrome to postmenopause did not find such an EDSS inflection; (2) MS and DMD do not seem to alter the age of menopause onset; and (3) HRT in menopausal MS patients has not shown consistent benefits.

Conclusion:

Menopause seems to be associated with transient symptom worsening, but the existence of an inflection in disability progression is still controversial. Properly designed studies are necessary to achieve conclusive results.
A novel and simple technique for correcting localised rotations in the early alignment stage
Authors: Alkadhimi Aslam
Published: August 2020

Correcting severe tooth rotations can be challenging. There are many ways to de-rotate teeth with fixed or removable appliances. Mechanically, the best and most effective way is one that produces a two-force couple system to rotate a tooth around its centre of rotation (longitudinal axis). The aim of this article was to introduce a simple and efficient technique using a closed coil to correct localised tooth rotations in the early alignment stage, utilising a simple two-force couple system. Furthermore, some of the biomechanical principles concerning de-rotation will be revisited.
Analysis of fatigue behaviour of drill pipe on pin-box connection
Authors: Ozguc Ozgur
Published: August 2020

Drilling is one of the costliest and risky activities in oil and gas industry due to complexity of interactions with downhole formation. Cyclic loads while drilling cause the initiation and growth of cracks in oil tubulars. This phenomenon, known as fatigue, results in permanent reduction of the failure-free service envelope of a certain tubular. Further, most of the drill string failures are triggered by fatigue, which results from repetitive cyclic bending loads and stresses in tensile or buckled drill strings. Fatigue is a cumulative and non-reversible condition induced by repetitive cyclic bending loads and tensile or buckled drill pipe stresses. Fatigue exists even though cyclic tension of the drill pipe material is much lower than static strength limit. Present work investigates fatigue capacity of the 4” WT38 drill pipe connection where cracks have been observed. In accordance with the geometry of connection, a hot spot stress from bending moment is calculated in the crack location in the first thread (upper) of the pin. The DNVGL-RP-C203 SN-curve B1 “in air” is used as relevant fatigue SN curve for the drill pipe thread location. Finite element method (FEM) is employed in modeling and analyzing of drill pipe on pin-box connections. With this method, various connections can be investigated relatively faster and cheaper compared with experimental tests. It is found that the fatigue failure may have been caused as a result of the cyclic load level and number of load cycles. A detailed discussion of the fatigue damage assessment concludes the paper.
Establishing Safety and Stability for Enhanced Treatment Engagement With the Unified Protocol: A Case Study
Authors: Mian Maha N. , Lin Betty , Hormes Julia M. , Earleywine Mitch
Published: August 2020

Despite the vast array of empirically validated treatments for psychopathological problems, interventions still require considerable client resources for engagement and success. For clients lacking safety and stability outside of therapy, numerous barriers to treatment can prevent improvement and lead to disengagement. In such cases, therapists can seek to understand clients’ difficulties with safety and stability. Developing both rapport and the client’s problem-solving abilities can instill a sense of agency, keeping clients in treatment for better outcomes overall. This case study describes the modified application of the Unified Protocol following safety planning and crisis management. “Mary,” a 23-year old female, presented to a training clinic with fluctuating mood episodes, trauma symptoms, and problem substance use; pre, post, and routinely collected session data with clinical report indicate symptom improvement and increased treatment engagement following client gains in safety, employment, and housing. This case illustrates the importance of the therapeutic alliance in establishing client safety to effectively deliver a transdiagnostic treatment to address core mechanisms underlying emotion dysregulation.
Increasing Transcutaneous Oxygen Pressure in Patients With Neuroischemic Diabetic Foot Ulcers Treated With a Sucrose Octasulfate Dressing: A Pilot Study
Authors: Lázaro-Martínez José Luis , García-Madrid Marta , García-Alamino Josep M. , Bohbot Serge , García-Klepzig José Luis , García-Álvarez Yolanda
Published: August 2020

Regarding the positive clinical outcomes of sucrose octasulfate impregnated dressing documented in neuroischemic diabetic foot ulcers (DFUs), we aimed to evaluate the microcirculatory status in patients with neuroischemic DFU through the use of sucrose octasulfate dressing. Eleven patients with neuroischemic DFU were included in a prospective pilot study between July 2019 and March 2020. We evaluated the effect in transcutaneous oxygen pressure (TcPO2; mm Hg) values within the use of a sucrose octasulfate dressing in the course of the healing process of neuroischemic DFUs (UrgoStart Contact, Laboratoires Urgo Medical). TcPO2 values were assessed at day 0 and monthly until wound healing was achieved. Additionally, wound healing process was evaluated using the Wollina score system and wound area surface, at day 0 and monthly until 20 weeks of follow-up or wound healing first occurred. TcPO2 values showed a significant increase between day 0 (29.45 ± 7.38 mm Hg) and wound closure (46.54 ± 11.45 mm Hg, P = .016), after dressing application. Wollina wound scores showed a significant improvement (4.2 ± 1.7 at day 0 to 5.4 ± 1.3 at the end of the study; P = .004). Median wound area at day 0 was 1.30 cm2, interquartile range [1.60-1] cm2, and 0.5 cm2 at week 4, interquartile range [1.1-0.1], P < .001. Median healing time was 8 weeks, interquartile range [8-5]. Treating a neuroischemic DFU with a sucrose octasulfate dressing in the standard of care showed an increase in skin oxygen pressure.
Short-term enhancement of motor neuron synaptic exocytosis during early aging extends lifespan in Caenorhabditis elegans
Authors: Ching Tsui-Ting , Chen Yen-Chieh , Li Guang , Liu Jianfeng , Xu X Z Shawn , Hsu Ao-Lin
Published: August 2020

Age-related mobility decline is often associated with negative physical and psychological outcomes, such as frailty, in the elderly population. In C. elegans, during the early stage of the aging process, a progressive deficit of synaptic exocytosis in the motor neurons results in a functional decline at the neuromuscular junctions, which eventually leads to degeneration of both neurons and muscles. This age-dependent functional decline can be ameliorated by pharmacological interventions, such as arecoline, a muscarinic AChR agonist known to promote synaptic exocytosis at the neuromuscular junctions. In this study, we found that a short-term treatment of arecoline during the early stage of aging, when the NMJ functional decline begins, not only slows muscle tissue aging, but also extends lifespan in C. elegans. We have also demonstrated that arecoline acts on the GAR-2/PLCβ pathway in the motor neurons to increases longevity. Together, our findings suggest that synaptic transmission in aging motor neurons may serve as a potential target for pharmacological interventions to promote both health span and lifespan, when applied at the early stage aging.

Impact statement

The functional decline of motor activity is a common feature in almost all aging animals that leads to frailty, loss of independence, injury, and even death in the elderly population. Thus, understanding the molecular mechanism that drives the initial stage of this functional decline and developing strategies to increase human healthspan and even lifespan by targeting this process would be of great interests to the field. In this study, we found that by precisely targeting the motor neurons to potentiate its synaptic releases either genetically or pharmacologically, we can not only delay the functional aging at NMJs but also slow the rate of aging at the organismal level. Most importantly, we have demonstrated that a critical window of time, that is the early stage of NMJs functional decline, is required for the beneficial effects. A short-term treatment within this time period is sufficient to extend the animals’ lifespan.
An Exploration of Employment-Related Personal Projects Undertaken by Women on Probation and Parole
Authors: Roddy Ariel L. , Morash Merry , Hoskins Kayla M.
Published: August 2020

This qualitative research investigates the extent to which 401 women under supervision identify employment-related personal projects (i.e., actions taken to achieve abstract goals) as a way to make their lives better. Psychological theory about personal projects and feminist pathways theory guided the analysis. Findings reveal how project meaningfulness, self-efficacy, and social support to carry out the project affect well-being. Structural barriers, disability, and transportation issues were also identified. Findings suggest that many women pursue and benefit from employment-related projects. Correctional agents can assist women by helping them choose meaningful projects and providing information, resources, and social support.
New York’s War on Drugs and the Impact on Female Incarceration Rates
Authors: Mair Colleen D.
Published: August 2020

Prior literature suggests that drug legislation in the late 1970s and 1980s caused the rapid increase in the female incarceration rate. Empirical investigations focused on the female incarceration rate specifically may provide important information to further our understanding of the factors that contributed to this increase. The purpose of this study is to determine how much of the change in the female incarceration rate in New York can be attributed to the introduction of the 1973 Rockefeller Drug Laws. These laws were introduced prior to most war on drugs legislation and, therefore, serve as a unique case study for this type of investigation.
Synergistic Fabrication of Dose–Response Chitosan/Dextran/β-Glycerophosphate Injectable Hydrogel as Cell Delivery Carrier for Cardiac Healing After Acute Myocardial Infarction
Authors: Hua Chongjun , Liu Jing , Hua Xiuhong , Wang Xinyu
Published: August 2020

The human mesenchymal stem cells (hMSCs) therapy offering an encouraging the new methods to establish the conveying on the chitosan (C)/dextran (D)/β-glycerophosphate (β-GP) loaded with hMSCs to enhance the acute myocardial infarctions. The synthesized hMSCs-CD@β-GP system displayed the ratio of determination modules, size of the pore, absorbency, and the swellings ratio in the assortment of the 65 ka, 149 ± 39.8 µm, 92.2%, 42 ± 1.38, and 29 ± 1.9, respectively. The fabricated hMSCs-CD@β-GP was highly stable and physicochemical investigated and confirmed the suitability of the materials for cardiac regeneration applications. The in vitro examinations of the injectable hydrogels with hMSCs-CD@β-GP have recognized that the improved survival rate of the cells, increased the pro-inflammatory expressions factors, pro-angiogenic factors analysis confirmed the promising results of the ejection of fractions, fibrosis area, vessel density with decreased infractions size, with suggesting that the remarkable improvement of the heart regenerative function after myocardial infarctions. The new synergistic approach of the injectable hydrogels with hMSCs could able appropriate for the effective treatment of cardiac therapies after acute myocardial infarctions.
Manipulation of Quercetin and Melatonin in the Down-Regulation of HIF-1α, HSP-70 and VEGF Pathways in Rat’s Kidneys Induced by Hypoxic Stress
Authors: Alshanwani Aliah R. , Shaheen Sameerah , Faddah Laila M. , Alhusaini Ahlam M. , Ali Hanaa M. , Hasan Iman , Hagar Hanan , Ahmed Raeesa , Alharbi Fatima M. B. , AlHarthii Alaa
Published: August 2020

Hypoxia may lead to inflammatory responses by numerous signaling pathways. This investigation intended to inspect the defensive role of Quercetin (Quer) and/ or Melatonin (Mel) against reno toxicity induced by Sodium nitrite (Sod ntr). Sod ntr injection significantly decreased blood hemoglobin concentration (Hb) with a concurrent increase in serum tumor necrosis factor- α, interleukin-6, C-reactive protein, creatinine, and urea levels. Over protein-expression of vascular endothelial growth factor and heat shock, protein-70 and mRNA of HIF-1α were also observed. Pretreatment of the Sod ntr- injected rats with the aforementioned antioxidants; either alone or together significantly improved such parameters. Histopathological examination reinforced the previous results. It was concluded that the combined administration of Quer and Mel may be useful as a potential therapy against renal injury induced by Sod ntr. HIF-1α and HSP-70 are implicated in the induction of hypoxia and its treatment.