bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of bacillus sp. NTLG2-20 and reduced nitrogen fertilization on soil properties and peanut yield
Authors: Chuong Nguyen Van
Published: July 2024

The excessive use of nitrogen (N) fertilizers has led to farmland degradation and reduced crop yields. To address this drawback, reducing the amount of nitrogen fertilizer and Bacillus sp. NTLG2-20 inoculant are the optimal cultivation method. The impact of different N rates (0, 20, and 40 kg ha-1) combined with the Bacillus sp. NTLG2-20 inoculant on soil chemical properties, growth, development, and peanut yield was designed in the field in Phuoc Hung commune, An Phu district from May to August 2023. The field experiment was designed with 6 treatments and 4 replications. The research results showed that different N rates adequately augmented soil chemical traits such as pH, cation exchange capacity (CEC), soil organic matter (SOM), total N, available phosphorous (AP), and exchangeable potassium (EK). Furthermore, different N fertilizers rates combined with Bacillus sp. NTLG2-20 inoculant adequately augmented plant height, number of leaves, total chlorophyll, nodulous number and weight per groundnut plant. Reducing N fertilizer application by 50% (20 kg N ha-1) was the optimal N reduction rate when combined with the Bacillus sp. NTLG2-20, which resulted in 17.6% higher peanut yield compared to no N application and no difference compared to 100% of recommended N application (P<0.01)). Bacillus sp. NTLG2-20 inoculant increased peanut yield by 19.6% when compared to no Bacillus sp. NTLG2-20 inoculant (P<0.01). Nitrogen – fixing ability of Bacillus sp. NTLG2-20 promoted peanut yield and reduced fifty percentage of the N fertilizer application. Bacillus sp. NTLG2-20 is the promising species for the production of biological fertilizer in the future.
Development of CaCO3 novel morphology through crystal lattice modification assisted by sulfate incorporation and vibration
Authors: Mangestiyono Wiji , Jamari J. , Bayuseno A.P. , Muryanto S.
Published: July 2024

CaCO3 has long been used as a filler to increase many properties of the material. The filler commonly consists of inexpensive materials that replace some volume of the more expensive materials, which can reduce the cost of the final product. CaCO3 morphology that can be used as filler depends on the filler's function, such as filler for paper, paint, rubber, or composite. A filler for composite materials is needed to increase interfacing interactions between the particulate fillers and the matrix. So, the particulate in a broader shape will be the best choice to function for such filler. In this research, in an attempt to increase the interfacing interaction, CaCO3 morphology was modified in such a way through crystal lattice modification assisted by sulfate incorporation and vibration. SEM analysis was implemented, and showed that the research successfully produced novel morphology in branchy-like polymorphs. FTIR analysis also proved that the crystal lattice has been modified. The morphology in branchy-like polymorph is supposed to increase interfacing interaction between CaCO3 as the filler and the matrix. The methods are also supposed to be implemented as the research is scaled up to commercial scale.
Potential Use of Human Mesenchymal Stem Cells (hMSCs) in Pancreatic Damage/Cancer
Authors: Eyüpoğlu Havva Özgen , Eyüpoğlu Erol , Serakinci Nedime
Published: July 2024

Pancreatic damage and pancreatic cancer pose significant challenges due to their complex pathogenesis, limited treatment options, and poor prognosis. In recent years, the potential use of human Mesenchymal Stem Cells (hMSCs) has been explored to address these complex pancreatic conditions and develop novel therapeutics. hMSCs, known for their regenerative and immunomodulatory properties, offer a novel therapeutic avenue for repairing damaged tissues and possibly inhibiting cancer progression. This communication discusses current research findings on the application of hMSCs in pancreatic damage and cancer treatment while evaluating hMSC-mediated gene therapy in pancreatic disorders. Moreover, the challenges and considerations associated with hMSC-based therapies and the potential best therapeutic approaches are discussed. Furthermore, the current scientific evidence regarding hMSCs in revolutionizing the management of pancreatic damage and cancer, offering future perspectives for improved therapeutic strategies for patients facing these daunting conditions, is critically discussed.
Policy Guidance for Direct-to-Consumer Genetic Testing Services: Framework Development Study
Authors: Onstwedder Suzanne Maria , Jansen Marleen Elizabeth , Cornel Martina Cornelia , Rigter Tessel
Published: July 2024

Background

The online offer of commercial genetic tests, also called direct-to-consumer genetic tests (DTC-GTs), enables citizens to gain insight into their health and disease risk based on their genetic profiles. DTC-GT offers often consist of a combination of services or aspects, including advertisements, information, DNA analysis, and medical or lifestyle advice. The risks and benefits of DTC-GT services have been debated and studied extensively, but instruments that assess DTC-GT services and aid policy are lacking. This leads to uncertainty among policy makers, law enforcers, and regulators on how to ensure and balance both public safety and autonomy and about the responsibilities these 3 parties have toward the public.

Objective

This study aimed to develop a framework that outlines aspects of DTC-GTs that lead to policy issues and to help provide policy guidance regarding DTC-GT services.

Methods

We performed 3 steps: (1) an integrative literature review to identify risks and benefits of DTC-GT services for consumers and society in Embase and Medline (January 2014-June 2022), (2) structuring benefits and risks in different steps of the consumer journey, and (3) development of a checklist for policy guidance.

Results

Potential risks and benefits of DTC-GT services were mapped from 134 papers and structured into 6 phases. In summary, these phases were called the consumer journey: (1) exposure, (2) pretest information, (3) DNA analysis, (4) data management, (5) posttest information, and (6) individual and societal impact. The checklist for evaluation of DTC-GT services consisted of 8 themes, covering 38 items that may raise policy issues in DTC-GT services. The themes included the following aspects: general service content, validity and quality assurance, potential data and privacy risks, scientific evidence and robustness, and quality of the provided information.

Conclusions

Both the consumer journey and the checklist break the DTC-GT offer down into key aspects that may impact and compromise individual and public health, safety, and autonomy. This framework helps policy makers, regulators, and law enforcers develop methods to interpret, assess, and act in the DTC-GT service market.
Narrowing the Digital Divide: Framework for Creating Telehealth Equity Dashboards
Authors: Luke Michael J , Craig Sansanee , Pak-Gorstein Suzinne , Arellano Marlíse , Zhang Jessica , Wright S Margaret , Chuo John , Scribano Philip V
Published: July 2024

Telehealth presents both the potential to improve access to care and to widen the digital divide contributing to health care disparities and obliging health care systems to standardize approaches to measure and display telehealth disparities. Based on a literature review and the operational experience of clinicians, informaticists, and researchers in the Supporting Pediatric Research on Outcomes and Utilization of Telehealth (SPROUT)–Clinical and Translational Science Awards (CTSA) Network, we outline a strategic framework for health systems to develop and optimally use a telehealth equity dashboard through a 3-phased approach of (1) defining data sources and key equity-related metrics of interest; (2) designing a dynamic and user-friendly dashboard; and (3) deploying the dashboard to maximize engagement among clinical staff, investigators, and administrators.
Title: "Exploring miR-10a/b Expression in Leukemia Cell Lines: Implications for Biomarker Discovery in Acute Leukemias" (Preprint)
Authors: yekta saman , sadeghizadeh afagh , Asghari kollahi Neda , khakpour golnaz
Published: July 2024

BACKGROUND

MicroRNAs (miRNAs) are short noncoding RNAs with broad regulatory functions in cells. Among these, miR10a and miR10b (miR10a/b) have been widely studied in cancer research due to their expressional association with various malignancies.

OBJECTIVE

This study aims to investigate the expressional changes of miR10a/b in HL-60 and MOLT-4 human cell lines, which serve as model systems for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), respectively, and compare these levels with those in peripheral blood mononuclear cells (PBMCs).

METHODS

MiRNAs were selected through a multistep filtering method using various databases. Specific primers with complementary sequences for stem-loop structured RNAs were designed. RNAs were extracted from cultured cells, and their expressional levels were measured using the RT-PCR technique.

RESULTS

Data analysis revealed that the expressions of miR10a/b were increased in both cell lines, HL-60 and MOLT-4.

CONCLUSIONS

This result suggests that miR10a/b can serve as prospective biomarkers for prognostic and diagnostic targets in AML and ALL malignancies.
The Role of the Giant Tortoises in the Ecosystem
Authors: Jinxiu Luo , Ruilu Yang
Published: July 2024

The Great King's beetle is a kind of large beetle widely distributed in tropical and subtropical areas of Asia. This paper aims to comprehensively analyze the multiple roles of the Great King's beetle in its natural ecosystem. Through literature review and field ecological observation, this study revealed the important functions of the King's flower tortoise in pollination, decomposition and food chain. The study showed that the King's flower tortoises have a positive impact on maintaining plant diversity by participating in the pollination process of plants. At the same time, their lifestyle in the larval stage promotes soil nutrient cycling and ecosystem health. In addition, the species' links in the food chain reveal its potential value in energy transfer and biological control. The results of the study are expected to provide a scientific basis for ecological conservation, biodiversity maintenance and natural ecosystem management.
violencia psicológica en torno a la promesa de los derechos humanos
Authors: Melgar Manzanilla Pastora
Published: July 2024

Este ensayo examina la relación entre la promesa de los derechos humanos y la violencia psicológica, centrándose en la ambigüedad y abstracción inherentes a la conceptualización y aplicación de estos derechos. Se analiza cómo los documentos político-jurídicos, como los pactos internacionales de derechos y constituciones, pueden generar falsas expectativas y perpetuar la desigualdad al no concretarse en mejoras tangibles para los grupos más vulnerables de la sociedad. Finalmente, se plantea la preocupación sobre cómo la falta de claridad en cuanto a la viabilidad de la implementación de los derechos puede erosionar la legitimidad de las autoridades y mantener la injusticia. Este análisis subraya la importancia de llevar a cabo una discusión franca y transparente sobre las limitaciones y las posibilidades reales de cumplimiento de los derechos humanos, así como de fomentar una mayor participación informada de la sociedad en la definición y protección de sus derechos.
Validez y confiabilidad de la versión breve del Inventario de Síntomas SA-45
Authors: Vizioli Nicolás Alejandro , Crespi Melina Claudia
Published: July 2024

Dada la prevalencia de los trastornos mentales y los síntomas psicológicos elevados, ha habido un llamado a la acción para ampliar los servicios de salud. Para brindar una atención óptima, es fundamental la detección temprana de los síntomas y la evaluación del estado psicológico. Las medidas de autoinforme tienen una amplia utilidad para evaluar diagnósticos específicos y explorar síntomas psicológicos. El objetivo de este estudio fue aportar nuevas evidencias psicométricas de la versión argentina de la versión breve del Inventario de Síntomas Psicológicos. Mediante un muestreo no probabilístico e intencional, se seleccionaron 760 individuos de 18 a 63 años (M = 28.1; DE = 8.61). A través de análisis factoriales confirmatorios se halló que el modelo de nueve factores correlacionados mostró un mejor ajuste y se encontraron evidencias acerca de su invariancia escalar, métrica y configural según género y región. Los factores mostraron mayormente valores de confiabilidad adecuados, concordantes con investigaciones previas. Se proporcionaron puntajes normativos T. Los resultados mostraron que el instrumento es válido y confiable, y podría ser una herramienta valiosa en diversos contextos, particularmente en la atención primaria, donde la evaluación exige tiempos muy breves e información de utilidad.
A Systematic Review on Ethnobotany and Bioactive Compounds of the Genus Ipomoea (Convolvulaceae)
Authors: Borlongan Kobe Montecastro , Torres Mark Anthony Jariol , Demayo Cesar , Llantos Orven
Published: July 2024

This systematic review focuses on the therapeutic properties of the Ipomoea genus by examining its bioactive components and ethnobotanical uses. The review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The project compiles indigenous information from many regions worldwide regarding the medicinal uses of Ipomoea species, serving as a basis for future research and the advancement of pharmaceutical endeavors. Among the 4297 studies identified in the study, only 152 met the criteria for inclusion. The species that was most commonly employed was Ipomoea batatas (L.) Lam; it was utilized for the treatment of diabetes, along with other medical ailments. The genus encompasses a diverse array of ailments, including cancer, diabetes, dermatological disorders, and gastrointestinal disorders. Ipomoea species possess bioactive compounds that have anti-inflammatory, antibacterial, antioxidant, and anticancer properties. Further investigation is necessary to scientifically validate the medicinal capabilities of these plants and their bioactive constituents. This study should encompass clinical trials and complete pharmacological assessments while also upholding appropriate consumption practices and respecting indigenous knowledge.
FORMULATION AND IN VITRO CHARACTERIZATION OF METOCLOPRAMIDE LOZENGES BY USING THE QUALITY BY DESIGN (QBD) APPROACH
Authors: Mustafa Muhammad Abid , Mahmood Aiman , Shahzad Seerat , Kanwal Nayyab , Rasheed Namra , Mahmood Mahgull , Amjad Umair , Saeed Muhammad Ahmed , Ahsan Muhammad Shahmir , Raza Shehzada Muhammad Afaq , Pervaiz Muhammad Haris , Hanif Raza , Ahmad Rania
Published: July 2024

Objective: Conventional dosage forms may not be suitable for all patients, especially those facing difficulty with swallowing, which results in reduced adherence to medication, impacting treatment outcomes. This study aimed to formulate and characterize metoclopramide lozenges using the quality-by-design approach to provide a patient-friendly alternative.
Materials and Method: Formulations were optimized using response surface methodology and a Design Expert, focusing on Metoclopramide, Citric Acid, and Carboxymethyl Cellulose, with hardness and dissolution as primary response variables. The experimental design involved 20 runs, six replications of the central point, and a quadratic model for improved model fitting, with adjustments made through transformation and numerical hill-climbing algorithms.
Results and Discussion: Formulations of metoclopramide lozenges were obtained through a systematic quality-by-design approach. Using numerical optimization, the formulation with the highest desirability score of 1.00 was selected, yielding a hardness of 14.55 kg and a dissolution time of 1.25 minutes. The optimal coded values were 1.53223 grams for Metoclopramide (A), 4.84302 grams for Citric acid (B), and 18.5048 grams for Carboxymethyl cellulose (C). The optimized formulation was subjected to in vitro testing to validate its performance, yielding a hardness ranging from 13.98 to 15.00 kg/cm2 and a dissolution time ranging from 1.11 to 2.23 minutes. The effectiveness of the QbD approach was confirmed as outcomes closely aligned with the targeted responses. 
Conclusions: The Quality by Design approach was found effective in optimizing the formulation of metoclopramide lozenges. Using the Design of Expert and Response Surface Methodology, an optimized formulation was obtained with the desired hardness and dissolution rate.
                 
Peer Review History:
Received 26 April 2024;   Revised 4 May 2024; Accepted 28 June; Available online 15 July 2024
Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com
Dr. Hatem Sameir Abbas, Al-Azhar University, Egypt, hsam8406@yahoo.com
ANTIMICROBIAL RESISTANCE PATTERNS AMONG BACTERIAL PATHOGENS ISOLATED FROM CLINICAL SAMPLES IN SANA'A HOSPITALS
Authors: Al-Tahish Ghamdan Ahmed Ali , Measar Mojahed Ali Hatem , Al-Safani Muaath Ahmed Hussein , Makeen Mortahda Ali Nasser , Al-Moyed Khaled Abdulkarim , Al-Shamahy Hassan Abdulwahab , Al-Haddad Ahmed Mohammed
Published: July 2024

Background and objectives: Yemen is among the developing nations where antimicrobial resistance (AMR) is posing a danger to public health. AMR can lead to increased morbidity and mortality from treatment failures and a lack of effective therapies. Particularly in the research arena, there is a dearth of knowledge about the antimicrobial resistance patterns of frequently isolated, locally occurring diseases. Therefore, the purpose of this study was to evaluate the diseases' microbiological profiles and resistance trends in Sana'a, Yemen.
Methods: In Sana'a, Yemen, a retrospective study was carried out at various governmental and private hospitals between June and September of 2020. Information about antibiotic susceptibilities and cultures was taken from the microbiology department's 2019 files. The data analysis method employed was descriptive statistics.
Results: This study includes 4156 pathogen isolates, with 58.2% of the isolates being Gram negative. Of all the isolates, urine (26.1 %, n = 1086) and pus specimens (24.6 %, n = 1025) demonstrated the greatest detection rates. The most often isolated pathogens were S. aureus (35.6%, n=1479), E. coli (29.2%, n=1215), P. aeroginosa (14.1%, n=586), and Klebsiella species (10.7%, n=443). The highest rates of resistance were found for cephalosporins (cefixime 90%, cefadroxil 87.9%, cefepime 72%, and ceftriaxone 70%) and penicillins (carbincillin 87%, amoxacillin 80%, and amoxacillin/clavulanic acid 77%). Gram positive and Gram negative isolates showed minimal resistance to linezolid and vancomycin, with Enterococcus showing higher resistance. Colistin was most effective against Gram negative, while E. coli, Klebseilla, and Proteus showed high resistance.
Conclusions: The high rate of resistance discovered in the current study in both Gram-positive and Gram-negative organisms is alarming and highlights the necessity of routinely determining the prevalence of resistance in a given area in order to guide empirical therapy and choose the most effective course of antibiotic treatment.
                  
Peer Review History:
Received 27 March 2024;   Revised 8 May 2024; Accepted 27 June; Available online 15 July 2024
Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Heba M. Abd El-Azim, Damanhour University, Egypt, h_m_abdelazim@hotmail.com
Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com
ANTIBIOTICS CONSUMPTION AMONG HOSPITALIZED PATIENTS IN INTENSIVE CARE UNITS AT SANA’A CITY, YEMEN
Authors: Al-Tahish Ghamdan A. , Alyahawi Ali A.
Published: July 2024

Background: Monitoring antibiotic consumption is crucial to addressing antimicrobial resistance. The aim of current study was to investigate the use and consumption of antibiotics in an intensive care unit in Sana'a, Yemen using DDD and DOT methods, and to our knowledge it is the first of its kind to study this topic.
Methods: A retrospective study on data from the ICU register. The study was carried out from September 2021 to February 2022 on hospitalized  patients of five ICUs of main hospitals at 2020. Antimicrobial consumption data were mostly collected manually. Data were analyzed and presented as defined daily dose (DDD) and days of therapy (DOT) per 1000 patient-days.
Results: A total of 1970 patients were included in this study and the overall consumption of antibiotics in ICUs was as high as 18,017.91 DDD per 1000 patient-days and as high as 17448.73 DOT per 1000 patient-days. The study results found that ceftriaxone, vancomycin, and meropenem were most frequently consumed using DDD and DOT methods among ICU patients, with results by DDDs per 1000 patient-days being 2479.23, 2124.55, and 1830.54, respectively, and results by DOTs per 1,000 patient days being 2,112.69. 2055.33 and 1890.86. The highest amount of antibiotics consumption among WHO AWaRe classification was for "watch" group of 26267.4 and 14674.5 DDDs per 1000 patient per day.
Conclusions: A high consumption of antimicrobial agents such as ceftriaxone, vancomycin and meropenem was found in ICUs of five selected hospitals. There was a significant increasing in “Watch” group antibiotics use and about three-fourths of the prescribed antibiotics were from this group. The study results can be used as a basis before designing any intervention aimed at improving antibiotic use in hospital intensive care units.
                   
Peer Review History:
Received 21 March 2024;   Revised 4 May 2024; Accepted 26 June; Available online 15 July 2024
Academic Editor: Dr. Rola Jadallah, Arab American University, Palestine, rola@aauj.edu
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Mahmut Yıldıztekin, Muğla Sıtkı Koçman University, Turkey, mahmutyildiztekin@mu.edu.tr
Dr. Masoumeh Divar, Shiraz University, Shiraz, Iran, zhaledivar@gmail.com
COMPARATIVE ANTI-TRICHOMONAS VAGINALIS ACTIVITY EVALUATION OF SAMBUCUS NIGRA L. FLOWERS AND FRUITS EXTRACTS
Authors: Erdemir Ecem , KAYALAR Husniye , Çavuş İbrahim , Özbilgin Ahmet
Published: July 2024

Background: Sambucus nigra or also known as Black elderberry or European elderberry is been used for the teatment and prevention of various diseases. The plant posseses health beneficial effects such as antimicrobial, antioxidant, antiulcerogenic, antidepressant, antidiabetic, antiviral and antiinflammatory.  However, there is limited report on the antitrichomoniasis activity of S. nigra. 
Objectives: The study aimed to comparatively analyze the in vitro trichomonicidal effects of various extracts prepared from both fruits and flowers of S. nigra. Half maximal inhibitory concentration (IC50) and minimum parasiticide (MPC) values of the extracts against metronidazole-resistant Trichomonas vaginalis 50143 strain were determined by the liquid microdilution method using 96-well microplates.
Results: After 48 hrs incubation with parasites, the highest activities were observed for 70% hydroethanolic extract, chloroform extract and methanol extract of fruits with IC50 values of 513, 531 and 566 µg/ml, respectively. Fruit extracts exhibited higher activity than flower extracts, and no activity was observed in methanol extract of flowers.
Conclusion: This study is the first comparative analysis of the anti-Trichomonas vaginalis activity of elderberry extracts. This study will serve as a reference source in isolating the components of elderberry fruits with antiparasitic activity.
                   
Peer Review History:
Received 23 March 2024;   Revised 6 May 2024; Accepted 27Metronidazole June; Available online 15 July 2024
Academic Editor: Dr. Amany Mohamed Alboghdadly, Ibn Sina National College for Medical Studies in Jeddah, Saudi Arabia, amanyalboghdadly@gmail.com 
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
EVALUATION OF ANTIBIOTIC SENSITIVITY OF ODONTOGENIC BACTERIA IN CERVICOFACIAL CELLULITIS IN THE CITY OF SANGMELIMA, CAMEROON
Authors: Nibeye Yannick Carine , Kopong Olivier Fola , Ngogang Marie-Paul , Zeh Honoré , Lyonga Emilia , M Charles Bengondo
Published: July 2024

Aim and objective: Cervicofacial cellulitis of dental origin is a polymicrobial infection characterized by inflammation of the deep spaces of the neck and face. These conditions can be life-threatening, as the bacteria can spread throughout the body, leading to descending necrotizing mediastinitis, sepsis and death. Management is greatly challenging because of microbial polymorphism, probabilistic antibiotic selection treatment sometimes being hesitant and inappropriate because of lack of consensus. The aim of this study was to evaluate the antibiotic susceptibility of odontogenic bacteria in cervicofacial infections.
Material and methods: This was a cross-sectional, descriptive study conducted from May 2019 to August 2020 in the odontostomatology and bacteriology departments of the Sangmelima District and Reference Hospitals in Cameroon. Thirty five samples were collected by swabbing or puncture. Specific culture media were used to inoculate samples. Sensitivity of isolated bacteria was assessed using the Kirby-Bauer diffusion disk method. Data analysis was performed using SPSS 23.0.
Results: Thirty samples were positive (85.7%). Bacteria isolated were Streptococcus (40%), Staphylococcus (30%), Pseudomonas (20%), Escherichia coli (6.7%) and Lactobacillus (3.3%). Sensitivity testing was performed with amoxicillin/clavulanic acid, metronidazole, gentamicin, ciprofloxacin, imipenem and clindamycin. Bacteria were more sensitive to amoxicillin/clavulanic acid, ciprofloxacin and imipenem. 
Conclusion: Bacteria identified in purulent secretions from cervicofacial cellulitis are much more sensitive to amoxicillin/clavulanic acid, ciprofloxacin and imipenem.
                  
Peer Review History:
Received 25 March 2024;   Revised 4 May 2024; Accepted 27 June; Available online 15 July 2024
Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
CONTRIBUIÇÕES DA TENDÊNCIA ATUALIZANTE PARA A AUTONOMIA NA PSICOTERAPIA: Estudo de caso
Authors: Almeida Maria Jaynne Silva , Filho José Antônio dos Santos
Published: July 2024

The present work was built on the experience of a specific supervised internship in psychology at a private university located in Fortaleza-CE, and aimed to discuss the contributions of the concept of updating tendency to the autonomy process of a client served in the Psychology Service. Applied. A case study was carried out with a client with the fictitious name Luciana, 34 years old, whose demand refers to a difficulty in imposing herself in relationships, both in marriage and in other relationships. To achieve the objective, the case study methodology was used. Regarding the results and discussion, during the development of Luciana's care it was possible to witness the continuous process of strengthening the client's autonomy. She, who before the sessions was submissive in her emotional relationships, gradually began to impose herself and explain to the other person what she wanted, no longer letting her husband and other family members define what she should or should do. do not do. This process made her take control of her own existence. It concludes with notes regarding the importance of the psychotherapeutic process and the contributions of the concept of actualizing tendency to the autonomy of the client served; As a facilitating environment was created for the emergence of her growth, based on a relationship of trust, Luciana had the opportunity to gradually take responsibility for her existence.
A INFLUÊNCIA DAS CAUSAS DAS LESÕES AUTOPROVOCADAS INTENCIONALMENTE NAS REGIÕES DO BRASIL EM 2015 E 2020
Authors: Dodô Gabriely Alves , Camêlo Edwirde Luiz Silva
Published: July 2024

Suicide is a growing public health issue in Brazil, with patterns and causes of self-inflicted injuries varying between regions and local cultures. This study analyzes the causes of self-inflicted injuries in the 27 federal units of Brazil in 2015 and 2020. Using data from DATASUS, variables of intentional self-harm injuries were identified, classified in the ICD-10 group. Analyses were conducted using the NeatMap and Psych packages, generating heatmaps and tables that allow visualization of the distribution and intensity of cases over the years. The results indicate an increase in suicides in 2020 compared to 2015, influenced by the pandemic period, during which many cases were not reported, yet there was still an increase. Hanging was the most common method in both years, reflecting the easy accessibility of this means in everyday life. States like São Paulo, Minas Gerais, and Rio Grande do Sul showed a higher association with the studied variables, indicating regional concern that demands specific public policies. Rio de Janeiro stood out with a significant increase in injuries related to cliffs and high places in 2020, due to specific geographical and cultural factors of the state. These injuries are associated with easy access to elevated areas and exacerbated social and economic pressure during the pandemic. It is concluded that patterns of self-inflicted injuries remained consistent, with some significant regional variations. These results are crucial for associating regions and causes of self-inflicted injuries, assisting in the development of future preventive measures, such as psychological support programs and specific community interventions for each region.
Critical behaviors of non-stabilizerness in quantum spin chains
Authors: Tarabunga Poetri Sonya
Published: July 2024

Non-stabilizerness – commonly known as magic – measures the extent to which a quantum state deviates from stabilizer states and is a fundamental resource for achieving universal quantum computation. In this work, we investigate the behavior of non-stabilizerness around criticality in quantum spin chains. To quantify non-stabilizerness, we employ a monotone called mana, based on the negativity of the discrete Wigner function. This measure captures non-stabilizerness for both pure and mixed states. We introduce Rényi generalizations of mana, which are also measures of non-stabilizerness for pure states, and utilize it to compute mana in large quantum systems. We consider the three-state Potts model and its non-integrable extension and we provide strong evidence that the mutual mana exhibits universal logarithmic scaling with distance in conformal field theory, as is the case for entanglement.
Trauma craneoencefálico moderado y severo en un hospital del suroccidente de Colombia: factores clínico-radiológicos relacionados con la mortalidad
Authors: Rivera Ordóñez Andrés Camilo , Jojoa Cultid Alexander Isidro , Mora Benitez Diego Andrés
Published: July 2024

Introducción: el trauma craneoencefálico es una patología con altos índices de mortalidad, por lo que es de gran relevancia identificar los factores que inciden en ella.
Materiales y métodos: se elaboró un estudio analítico entre los años 2020 y 2021, donde se incluyeron pacientes con trauma craneoencefálico moderado y severo, se caracterizaron las variables más relacionadas con el pronóstico, como aspectos demográficos, clínicos y radiológicos, y se analizó la asociación entre la mortalidad y estas variables.
Resultados: la mortalidad hospitalaria fue del 22,8?%, encontrando como variables relacionadas la frecuencia respiratoria, la anisocoria, el reflejo pupilar y la atención en unidad de cuidados intensivos (UCI), y como factor relacionado con supervivencia, el número de días de estancia hospitalaria.
Discusión: la mortalidad por trauma craneoencefálico es más elevada en países de ingresos medianos y bajos, posiblemente en relación con una mayor cantidad de accidentes de tránsito y un acceso limitado a tratamientos. Los factores asociados en el estudio se respaldan con estudios previos y se subraya la importancia de las alteraciones pupilares en la evaluación del paciente.
Conclusiones: es fundamental un examen físico completo desde el momento del ingreso, pues hallar taquipnea, anisocoria, ausencia del reflejo pupilar o signos de choque, puede dictar el pronóstico. Aunque la literatura global se centra en la caracterización del TCE, este estudio subraya la necesidad de una mayor investigación sobre factores que permitan predecir cursos hospitalarios tórpidos con desenlaces fatales.
Heteropessimism and the Pleasure of Saying “No”
Authors: Wrisley Samantha Pinson
Published: July 2024

Using Lauren Berlant’s keynote at the 2019 Duke Feminist Theory Workshop as a starting point, this article offers a comparative reading of feminism’s “heteropessimistic turn” and the involuntarily celibate (i.e., incel) movement. In doing so, I demonstrate that both groups are saying “no” to certain elements of what Berlant refers to as “the pleasure regimes of sexual normativity.” I focus on the affective function of heteropessimism—what Asa Seresin identifies as its “anesthetic feeling”—arguing that it affectively soothes but politically stultifies the feminist movement. Framing the incel movement in a heteropessimistic light, I dispute the common perception of incels as ‘merely’ misogynistic and argue that their totalizing sexual nihilism indicates a broader hatred of, and disidentification with, the politics of heterosexual desire. Introducing the example of “Black Pill Feminists,” I take the heteropessimistic connections between feminism and incel to their logical conclusion, showing that feminist heteropessimism’s inherent essentialism affectively cements the incongruous ideological positions of feminism to incel’s sexual nihilism. I conclude with an argument for the naturalization of negativity as part of a broader move toward accepting the ambiguities of heterosexual desire and the antagonism(s) that drive it.
Sketches on the Affectivity of Sexual Violence Survivorhood
Authors: Hodges Lynsay
Published: July 2024

Before the revelations of #MeToo, rape existed. It still exists. It will exist for the foreseeable future. But what of those who have experienced sexual violence and come out the other side? What of these ‘survivors’ — how are their lives altered? In this piece of work, I use vignettes inspired by Kathleen Stewart’s (2007) method in Ordinary Affects to explicate on how it feels to be a survivor. Drawing primarily on the postphenomenological framework of Sara Ahmed (2014), I combine both longer academic screeds with shorter, creatively written yet autobiographic scraps to capture the various states of affectivity central to survivorhood, such as shame, anger, abjection, and anxiety. Flashbacks run as a theme throughout, both in the very text itself but also in their importance to the experiencing and re-experiencing of trauma, in their nature as catalysts for recollection and feeling. I also explain, using Berlant (2001), my understanding of trauma as a ‘slow death.’ These sketches, then, reveal the messy, entangled nature of the emotions of survivors, whilst leaving room for a conversation to develop within the fields of affect theory and trauma studies.
Efeito da estimulação elétrica neuromuscular em pacientes críticos em unidade de terapia intensiva- uma revisão integrativa.
Authors: Pereira de Souza Caroligia , Mafra Freire Afonso José , Flores Malaquias Lorena , Trindade Santos Kleyton
Published: July 2024

O objetivo dessa revisão sistemática é apresentar a repercussão da estimulação elétrica neuromuscular em pacientes de unidade de terapia intensiva, através de estudos do tipo ensaios clínicos. Trata-se de uma revisão integrativa da literatura, onde os estudos foram selecionados a partir das seguintes etapas: elaboração da questão de pesquisa e tema, estabelecimento do tipo de estudo para seleção dos artigos, critérios de elegibilidade, busca na base de dados e análise rigorosa dos estudos para verificar sua relevância ao tema proposto nesta revisão. A busca que fundamentou esta revisão foi norteada  pela seguinte questão de pesquisa: Quais os efeitos da Estimulação Elétrica Neuromuscular em pacientes submetidos à terapia intensiva? A partir da análise realizada para a seleção dos artigos, foram selecionados 11 estudos para compor esta revisão. Em conclusão, ainda não há um consenso sobre a eficácia do uso da EENM em pacientes de UTI já que pela heterogeneidade das amostras, amostras muito pequenas e falta de protocolo impossibilita a comparação entre os estudos e/ou interfere na condução de novos estudos, há escassez de ensaio clínicos randomizados bem conduzidos e com baixo risco de viés sobre o assunto, questões como tempo, segurança, dose e resultado permanecem sem respostas concretas. A maioria dos estudos utilizados para esta revisão relataram não haver benefícios na utilização da EENM em pacientes críticos em cuidados intensivos tanto no ganho de força quanto na mobilização precoce, tempo de internamento e tempo de ventilação mecânica.
Potencialidades e limitações da assistência de enfermagem em atenção às crianças com transtorno do espectro autista: revisão integrativa
Authors: Vieira dos Santos Jéssica , Rosália Teixeira Luz Rosália , Argolo Teixeira Marizete , Pereira Lobo Marcio , Canuta Cardoso Climaco Layres
Published: July 2024

Este estudo tem como objetivo é identificar na literatura científica as potencialidades e limitações da assistência de enfermagem às crianças com Transtorno do Espectro Autista.  Trata-se de uma revisão integrativa da literatura realizada entre julho e agosto de 2022, nas plataformas SciELO, Google Acadêmico e BVS. Foram utilizados os descritores: “Transtorno do Espectro Autista”, “Criança” e “Enfermagem” com a associação do operador booleano AND.  Tendo como critérios de inclusão: artigos completos em português, publicados entre 2017 e 2022, acessíveis gratuitamente e que estivessem relacionados com o escopo dessa pesquisa.  Foram identificados 15 artigos, analisados pela técnica de análise de conteúdo. Os resultados revelaram três categorias de análise: C1 - Atuação do enfermeiro na assistência à criança com Transtorno do Espectro Autista; C2 - Necessidade de capacitação e formação continuada; C3 – Importância de instruir os enfermeiros para que possam aplicar os instrumentos que possibilite o diagnóstico precoce do Transtorno do Espectro Autista. Conclui-se que é necessário que o enfermeiro tenha conhecimento suficiente para identificar sinais e sintomas característicos do Transtorno do Espectro Autista, facilitando que numa abordagem multiprofissional envolvendo psicólogo e psiquiatra trace precocemente o diagnóstico, pois vai favorecer a eficiência das atividades terapêuticas favorecendo uma melhor qualidade de vida da criança.
Ansiedade e estresse em adolescentes no ensino médio: ação de florais de Bach
Authors: Senna Sueli Moreno , Alves Bianca Vitória dos Santos , Pinto Rogelia Herculano , Lira Maria da Conceição Cavalcanti , Silva Maria Betânia Bezerra , De Albuquerque Kátia Cristina Carrera , Campos Katia Rejane Bezerra
Published: July 2024

O objetivo desse estudo foi verificar o efeito do Remédio Emergencial sobre a ansiedade e o estresse de alunos do terceiro ano do ensino médio de uma escola estadual de referência do agreste de Pernambuco. Trata-se de estudo de intervenção duplo cego quantitativo. Os alunos preencheram o questionário sociodemográfico, Inventário de Ansiedade Traço-Estado (IDATE-A-T e A-E) e Lista de Sinais e Sintomas de Estresse (LSS). Posteriormente, foram divididos em dois grupos: floral ou placebo, distribuídos por conveniência conforme a classificação do IDATE-A-T. Após 21 dias, os alunos preencheram novos instrumentos (IDATE A-E e LSS). Não houve diferença entre os escores de ansiedade estado e de estresse antes e depois do uso do floral, embora a correlação entre os escores de IDATE-A-T e IDATE-A-E e LSS, após o uso do floral, tenham sido reduzidas. Dessa forma, concluímos que o Remédio Emergencial reduziu a influência do traço de ansiedade sobre a ansiedade e sobre os sinais e sintomas de estresse. Percebe-se a necessidade da prescrição individual dos florais, pois as particularidades são perdidas nas médias. Embora sejam necessários mais estudos sobre a temática, o Remédio Emergencial apresenta potencial para atuar de forma positiva sobre os estados de estresse e de ansiedade dessa faixa etária.
Análise da presença de sutura metópica e de ossos suturais nos diferentes formatos de crânio separados por sexo
Authors: Pires da Silva Geovana , Silvério Carvalho Vieira Camila , Bernardino Júnior Roberto
Published: July 2024

Com o aumento dos acidentes em região de cabeça e pescoço, faz-se importante o conhecimento sobre variações anatômicas como o metopismo e ossos suturais visto que,  frente a avalição rápida do exame imaginológico de pacientes traumatizados, tais achados podem ser confundidos com fraturas cranianas, induzindo a erro de diagnóstico e de planejamento. Objetivou-se analisar a presença de metopismo e de ossos suturais nos diferentes crânios pertencentes ao Departamento de Anatomia Humana da Universidade Federal de Uberlândia. Os crânios selecionados foram separados em quarenta femininos e quarenta masculinos e classificados em dolicocefálicos, mesocefálicos e braquicefálicos. Depois, analisou-se a incidência de metopismo e de ossos suturais. Os resultados foram avaliados quantitativamente por testes estatísticos de Kruskal Wallis com p<0,05. Vinte e dois eram braquicefálicos, sendo onze femininos e onze masculinos; trinta eram mesocefálicos, sendo doze femininos e dezoito masculinos; e vinte e oito eram dolicocefálicos, sendo dezessete femininos e onze masculinos. Encontrou-se seis crânios com metopismo completo, sendo três femininos e três masculinos; dez crânios com metopismo incompleto tipo násio, sendo seis femininos e quatro masculinos; e cinquenta crânios com ossos suturais. É necessária a divulgação de dados que alertem sobre a importância de se conhecer as variações anatômicas e de ser cauteloso na interpretação de exames imaginológicos de pacientes traumatizados.
A utilização da infovis para a tomada de decisão gerencial em saúde: revisão de escopo
Authors: Da Hora Ferreira Ariedna , Fontes de Carvalho Mailson
Published: July 2024

Trata-se de revisão de escopo, com objetivo de explorar a literatura acerca da utilização de ferramentas de Infovis no contexto da tomada de decisões gerenciais em saúde pública. O protocolo de revisão foi estruturado de acordo com as diretrizes do Instituto Joanna Briggs. A coleta e seleção das publicações foi realizada nas bases de dados Scielo, Pubmed via MEDLINE e CINAHL, com a aplicação criteriosa dos operadores booleanos "AND" e "OR", a partir dos descritores: “health”, “health manager”, “information design”, “health information manager. Como resultado desse esforço, foram incorporados nove artigos de acesso aberto, sendo sete em inglês, um em espanhol e um em português, a fim de enriquecer a revisão. Os estudos analisados destacam consistentemente a importância crucial das ferramentas de Visualização de Dados (Infovis) na otimização dos processos de gestão em saúde. Essas ferramentas proporcionam uma abordagem altamente eficaz para compreender e analisar informações complexas, bem como para orientar de forma mais eficiente as decisões relacionadas à saúde pública. O uso dessas ferramentas é essencial na gestão da saúde, pois simplifica a interpretação de dados complexos, facilitando uma compreensão mais rápida e profunda das informações essenciais, proporcionando valioso suporte aos gestores.
Resenha crítica do livro: “organ transplantation and native peoples: an interdisciplinary approach”
Authors: Resende Ferreira Melissa
Published: July 2024

Por ser uma resenha, o trabalho em questão não tem resumo, atendendo a seguinte orientação de submissão: "Todos os artigos submetidos à Revista Saúde.Com, com exceção das contribuições enviadas às seções Resenha ou Cartas, deverão ter resumo na língua portuguesa e em inglês."
A competência de pensamento crítico como estratégia para romper bolhas no mundo atual visando o resistir e coexistir da enfermagem
Authors: Andrade Dias Joana Angélica
Published: July 2024

Ao longo dos dias comemorativos da XV Semana de Enfermagem de Jequié, conseguimos imergir nas questões que apontam para a existência de bolhas visíveis e invisíveis que precisam ser rompidas no mundo atual a fim de que a Enfermagem possa resistir e coexistir.
Dentre essas bolhas, foi  abordada a desunião e desmobilização política dos profissionais da Enfermagem (ai inclusos os graduandos que encontram-se também politicamente desmobilizados) como “bolha macro”, a qual ao ser rompida facilitaria o rompimento das “bolhas micro”, a exemplo da verdadeira integração ensino-serviço, da luta pelo pagamento do piso salarial e aprovação da carga horária de trabalho, a implementação da Sistematização da Assistência de Enfermagem em todas as instituições de atuação da Enfermagem, a necessidade de maior valorização da profissão, a tão sonhada humanização da assistência, a aprovação das novas Diretrizes Curriculares Nacionais para os Cursos de Graduação em Enfermagem, a precarização do trabalho e da formação profissional, entre outras...
PHYSICOCHEMICAL AND ORGANOLEPTIC QUALITY OF CHICKEN FRIED MEATBALLS BROILER USING FLOUR IS DIFFERENT
Authors: Zulkarnain D , Indi A , Hafid H , Suryaningsi D P , Aku A S , M Munadi L O , Libriani R
Published: July 2024

Fried meatballs are different from meatballs in general. Usually, meatballs are served with hot sauce. However, fried meatballs with a crunchy texture can be consumed as a snack. Meatballs are generally gravy, and noodles or vegetables are added, while fried meatballs are processed through boiling and frying to extend their shelf life. The research aims to produce quality processed products by adding different flours through physicochemical and organoleptic tests that have been carried out at the Laboratory of Animal Product Processing Technology, Faculty of Animal Science, Halu Oleo University in November 2022 using a Completely Randomized Design of 5 treatments 5 repetitions by adding various types of flour with different concentrations repeated five times. The research results from adding various types of flour to fried meatballs for broiler chicken meat have a significant effect on physicochemical quality, especially pH, water holding capacity, cooking loss, and swelling capacity. In contrast, organoleptic quality significantly affects color, taste, elasticity, and general acceptance but does not significantly affect shape, texture, and aroma.