bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful management of a distal vessel perforation through a single 8‐French guide catheter: Combining balloon inflation for bleeding control with coil embolization
Authors: Tarar Muhammad N.J. , Christakopoulos Georgios E. , Brilakis Emmanouil S.
Published: April 2015

Coronary perforation is an infrequent, but serious complication of percutaneous coronary intervention (PCI), and is more likely to occur with complex (such as chronic total occlusion) PCI and use of atheroablative devices. For main vessel perforations, the “dual catheter” technique is usually employed in which a balloon is delivered over the first guide catheter to stop bleeding, whereas the covered stent is delivered through a second guide catheter. This is required because the large profile of the currently commercially available covered stents precludes fitting within even an 8‐French guide together with a balloon. However, coil embolization for distal artery wire perforation and collateral vessel perforation can be achieved through a microcatheter that can fit along with a balloon within an 8‐French guide catheter, obviating the need for a second guide catheter. We describe a case in which a distal artery wire perforation was successfully treated using a single 8‐French guide catheter. © 2015 Wiley Periodicals, Inc.
Adult‐onset Diamond‐Blackfan anemia with a novel mutation in the exon 5 of RPL11: too late and too rare
Authors: Flores Ballester Elena , Gil‐Fernández Juan José , Vázquez Blanco Miguel , Mesa José M. , de Dios García Juan , Tamayo Ana T. , Burgaleta Carmen
Published: April 2015

Key Clinical Message

Diamond‐Blackfan anemia (DBA) is a congenital erythroid aplasia usually diagnosed in the early infancy and associated with mutations or large deletions in 11 ribosomal protein (RP) genes. Adult patients with severe, transfusion dependence, aregenerative anemia might have a genetic‐in‐origin disease with an atypical presentation. Late onset nonclassical DBA should be ruled out and mutations of RP genes studied.
Geographical and Geological Origin of Natural Graphite Heavily Influence the Electrical and Electrochemical Properties of Chemically Modified Graphenes
Authors: Wong Colin Hong An , Sofer Zdeněk , Pumera Martin
Published: April 2015

Natural graphite is an important precursor for the production of chemically modified graphenes in bulk quantities for electrochemical applications. These natural graphites have varying fundamental properties due to the different geological processes and environments at their points of origin, which are expected to affect their chemical reactivity and hence the properties of the derived graphene materials. Four different natural graphites with known geographical and geological origins were exposed to a modified Hummers oxidation method and the resulting graphite oxides were studied. The graphite oxides were shown to have different extents of oxidation and types of oxygen groups, which directly influenced their electrochemical properties. These differences were propagated further in the subsequent chemical reduction of the graphite oxides, and the reduced graphene oxides exhibited significantly different reduction efficiencies and electrical conductivities. These findings show that the choice of natural graphite of known origin is important to synthesize chemically modified graphenes with a desired set of properties.
ChemInform Abstract: A Novel, Layered Phase in Ti‐Rich SrTiO3 Epitaxial Thin Films.
Authors: Martin Lane W.
Published: April 2015

The growth, structure, and properties of the Ti‐rich portion of the SrTiO3—TiO2 phase diagram in and around the eutectic composition is investigated.
ChemInform Abstract: Synthesis, Crystal Structure, Resistivity, Magnetic, and Theoretical Study of ScUS3.
Authors: Prakash Jai , Mesbah Adel , Ward Matthew D. , Lebegue Sebastien , Malliakas Christos D. , Lee Minseong , Choi Eun Sang , Ibers James A.
Published: April 2015

Black needle‐shaped crystals of the title compound are prepared in high yield from stoichiometric amounts of the elements (1173 K, 96 h; slow cooling).
ChemInform Abstract: Trivalent Cation‐Controlled Phase Space of New U(IV) Fluorides, Na3MU6F30 (M: Al3+, Ga3+, Ti3+, V3+, Cr3+, Fe3+): Mild Hydrothermal Synthesis Including an in situ Reduction Step, Structures, Optical, and Magnetic Properties.
Authors: Yeon Jeongho , Smith Mark D. , Morrison Gregory , zur Loye Hans‐Conrad
Published: April 2015

Single crystals of the title compounds are hydrothermally synthesized in nearly quantitative yields from aqueous mixtures of UO2(OAc)2, NaF, HF, and Ti2O3, or V2O5, GaF3, or FeF2 for Na3MU6F30 (M: Ti, V, Ga, Fe), and from aqueous mixtures of NaUF5, HF, and Na3AlF6, or CrF3 for Na3MU6F30 (M: Al, Cr) (autoclave, 200 °C, 1 d).
ChemInform Abstract: Novel Organic—Inorganic Hybrid Monomeric Keggin‐Type Phosphotungstate Containing Heterometallic {Ni6WNi} Clusters.
Authors: Liu Jing‐Wen , Liu Yong‐Chao , He Huan , Yang Bai‐Feng , Yang Guo‐Yu
Published: April 2015

The new compound [Ni(H2O)(en)2][WO4]{ [Ni6(OH)3(H2O)2(en)3 (imi)2](B‐α‐PW9O3 4)}·2H2O (imi: imidazole) is hydrothermally synthesized from a mixture of NiCl2, Na9[A‐α‐PW9O34], imi, en, and H2O (autoclave, 160 °C, 3 d, 56% yield).
ChemInform Abstract: Highly Enantioselective One‐Pot Synthesis of Chiral β‐Hydroxy Sulfones via Asymmetric Transfer Hydrogenation in an Aqueous Medium.
Authors: Zhang Dacheng , Cheng Tanyu , Zhao Qiankun , Xu Jianyou , Liu Guohua
Published: April 2015

The nucleophilic substitution reaction of α‐bromoketones with sodium sulfinates followed by Ru‐catalyzed asymmetric transfer hydrogenation using sodium formate as hydrogen source provides β‐hydroxy sulfones in high yields and excellent enantioselectivities.
ChemInform Abstract: Evaluation of Structural Effects of Acyclic and Macrocyclic Ligands Derived from (R,R)‐Cyclohexane‐1,2‐diamine in the Enantioselective Cu(II)‐Catalyzed Henry Reaction.
Authors: Cerisoli Lucia , Grilli Stefano , Savoia Diego
Published: April 2015

Two new ligands with acyclic and macrocyclic structure are synthesized and tested in the Henry reaction of benzaldehyde with nitromethane.
ChemInform Abstract: NH4PF6‐Promoted Cyclodehydration of α‐Amino Carbonyl Compounds: Efficient Synthesis of Pyrrolo[3,2,1‐ij]quinoline and Indole Derivatives.
Authors: Ji Xiao‐Ming , Zhou Shu‐Juan , Deng Chen‐Liang , Chen Fan , Tang Ri‐Yuan
Published: April 2015

Title compounds (II), (IV), and (VI) are efficiently and conveniently synthesized by a metal‐free cyclodehydration strategy.
ChemInform Abstract: I2‐Catalyzed Regioselective Oxo‐ and Hydroxy‐Acyloxylation of Alkenes and Enol Ethers: A Facile Access to α‐Acyloxyketones, Esters, and Diol Derivatives.
Authors: Reddi Rambabu N. , Prasad Pragati K. , Sudalai Arumugam
Published: April 2015

The simple regioselective oxo‐acyloxylation process of alkenes and enol ethers with carboxylic acids provides α‐acyloxyketones and esters.
ChemInform Abstract: Metal‐Free Alkynylation of α‐C—H Bonds of Ethers with Ethynylbenziodoxolones.
Authors: Zhang Ruo‐Yi , Xi Long‐Yi , Zhang Lei , Liang Shuai , Chen Shan‐Yong , Yu Xiao‐Qi
Published: April 2015

C—H bonds adjacent to an oxygen or nitrogen atom are effectively alkynylated by ethynylbenziodoxolones under mild conditions with moderate to good yields.
ChemInform Abstract: Pd‐Catalyzed Cross‐Coupling Reactions of Less Activated Alkenyl Electrophiles (for Tosylates and Mesylates) with Tosylhydrazones: Synthesis of Various 1,3‐Dienes.
Authors: Patel Poojan K. , Dalvadi Jignesh P. , Chikhalia Kishor H.
Published: April 2015

Title reaction results in the formation of various alkenyl derivatives.
ChemInform Abstract: Transition Metal‐Free Direct Trifluoromethylation of 2,3‐Dihydropyridin‐4(1H)‐ones at Room Temperature.
Authors: Yu Yi‐Yun , Ranade Adwait R. , Georg Gunda I.
Published: April 2015

A radical mechanism is assumed to occur.
ChemInform Abstract: Broad Scope Hydrofunctionalization of Styrene Derivatives Using Iron‐Catalyzed Hydromagnesiation.
Authors: Jones Alison S. , Paliga James F. , Greenhalgh Mark D. , Quibell Jacob M. , Steven Alan , Thomas Stephen P.
Published: April 2015

An operationally simple, chemo‐ and regioselective hydromagnesiation reaction generates benzylic Grignard reagents.
ChemInform Abstract: Visible‐Light‐Driven Difluoroacetamidation of Unactive Arenes and Heteroarenes by Direct C—H Functionalization at Room Temperature.
Authors: Wang Lin , Wei Xiao‐Jing , Jia Wen‐Liang , Zhong Jian‐Ji , Wu Li‐Zhu , Liu Qiang
Published: April 2015

The mild, scalable method tolerates a broad scope of electron‐rich and electron‐deficient aromatic and heteroaromatic systems.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of Styrenes with Aryl Methyl Ketones in Ionic Liquids: Direct Access to Cyclopropanes.
Authors: Cotugno Pietro , Monopoli Antonio , Ciminale Francesco , Milella Antonella , Nacci Angelo
Published: April 2015

This method uses molten tetrabutylammonium acetate as ionic liquid.
ChemInform Abstract: Efficient and Highly Enantioselective Construction of Trifluoromethylated Quaternary Stereogenic Centers via High‐Pressure Mediated Organocatalytic Conjugate Addition of Nitromethane to β,β‐Disubstituted Enones.
Authors: Kwiatkowski Piotr , Cholewiak Agnieszka , Kasztelan Adrian
Published: April 2015

In comparison to previously developed methods, this high pressure procedure offers several advantages such as a much broader substrate scope, a lower loading of commercially available catalysts, shorter reaction times, and higher enantioselectivities.
ChemInform Abstract: Synthesis of γ‐Nitroaldehydes Containing Quaternary Carbon in the α‐Position Using a 4‐Oxalocrotonate Tautomerase Whole‐Cell Biocatalyst.
Authors: Radivojevic Jelena , Minovska Gordana , Senerovic Lidija , O'Connor Kevin , Jovanovic Predrag , Savic Vladimir , Tokic‐Vujosevic Zorana , Nikodinovic‐Runic Jasmina , Maslak Veselin
Published: April 2015

The resulting γ‐nitroaldehydes exhibit moderate antifungal activity and mild in vitro cytotoxicity against human fibroblasts.
ChemInform Abstract: Synthesis of Amides Through an Oxidative Amidation of Tetrazoles with Aldehydes under Transition‐Metal‐Free Conditions.
Authors: Du Juan , Luo Kai , Zhang Xiuli
Published: April 2015

Amides (III) (30 examples) are efficiently synthesized by a simple, inexpensive, and environmentally friendly one‐pot procedure in good yields.
ChemInform Abstract: Synthesis of Diaryl Thioethers from Aryl Halides and Potassium Thiocyanate.
Authors: Hajipour Abdol R. , Pourkaveh Raheleh , Karimi Hirbod
Published: April 2015

A novel Pd‐catalyzed synthesis of symmetric diaryl sulfides from aryl halides and KSCN is developed.
ChemInform Abstract: Facile‐Prepared Sulfonated Water‐Soluble PEPPSI‐Pd‐NHC Catalysts for Aerobic Aqueous Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Zhong Rui , Poethig Alexander , Feng Yinkai , Riener Korbinian , Herrmann Wolfgang A. , Kuehn Fritz E.
Published: April 2015

The catalyst is shown to be active for the Suzuki—Miyaura cross‐coupling reaction.
ChemInform Abstract: Pd‐ and Cu‐Catalyzed Stereo‐ and Regiocontrolled Decarboxylative/C—H Fluoroalkenylation of Heteroarenes.
Authors: Rousee Kevin , Schneider Cedric , Couve‐Bonnaire Samuel , Pannecoucke Xavier , Levacher Vincent , Hoarau Christophe
Published: April 2015

Alkenylcopper intermediates generated from (Z)‐ and (E)‐α‐fluoroacrylic acids and CuCO3 undergo stereo‐ and regioselective Pd‐catalyzed coupling reactions with heteroarenes.
ChemInform Abstract: Copper‐Mediated/Catalyzed Oxyalkylation of Alkenes with Alkylnitriles.
Authors: Bunescu Ala , Wang Qian , Zhu Jieping
Published: April 2015

Phthalides and isochromanones are accessible by the oxyalkylation of benzamide alkenes with alkylnitriles in the presence of stoichiometric amounts of copper salts.
ChemInform Abstract: Palladium‐N‐Heterocyclic Carbene (NHC)‐Catalyzed Asymmetric Synthesis of Indolines Through Regiodivergent C(sp3)—H Activation: Scope and DFT Study.
Authors: Katayev Dmitry , Larionov Evgeny , Nakanishi Masafumi , Besnard Celine , Kuendig E. Peter
Published: April 2015

The Pd‐catalyzed asymmetric cyclization reaction of substrates (I) and (IV) provides two regioisomeric products with low to excellent enantioselectivities.
ChemInform Abstract: Preparation of Ruthenium Azido Complex Containing a Tp Ligand and Ruthenium‐Catalyzed Cycloaddition of Organic Azides with Alkynes in Organic and Aqueous Media: Experimental and Computational Studies.
Authors: Wang Tsang‐Hsiu , Wu Feng‐Ling , Chiang Guan‐Ru , He Sheng‐Ting , Lo Yih‐Hsing
Published: April 2015

Novel ruthenium complexes bearing an azido ligand are prepared and successfully applied as catalyst to the regioselective 1,3‐dipolar cycloaddition of benzyl azides to terminal alkynes.
ChemInform Abstract: Organocatalytic Morita—Baylis—Hillman/Michael/Acetalization Cascade: Procedure‐Controlled Diastereodivergence in the Asymmetric Synthesis of Fully Substituted Tetrahydropyrans.
Authors: Han Bo , Xie Xin , Huang Wei , Li Xiang , Yang Lei , Peng Cheng
Published: April 2015

The presented approach allows the production of two synthetically important compounds with excellent stereo control in a one‐pot operation.
ChemInform Abstract: A Facile and General Approach to 3‐((Trifluoromethyl)thio)‐4H‐chromen‐4‐one.
Authors: Xiang Haoyue , Yang Chunhao
Published: April 2015

Compounds (I) react with active electrophilic trifluoromethylthio species generated in situ from AgSCF3 and trichlorocyanuric acid to give the title products (III).
ChemInform Abstract: Enantio‐ and Diastereoselective Access to Distant Stereocenters Embedded withinTetrahydroxanthenes: Utilizing ortho‐Quinone Methides as Reactive Intermediates in Asymmetric Broensted Acid Catalysis.
Authors: Hsiao Chien‐Chi , Liao Hsuan‐Hung , Rueping Magnus
Published: April 2015

Using BINOL‐derived organocatalysts NBP and TBP, cyclocondensation of cyclohexa‐1,3‐diones with 2‐hydroxybenzhydrols gives the annulated tetrahydro‐1H‐xanthen‐1‐ones in good yields with high enantioselectivity.
ChemInform Abstract: Primary Amino Acid Catalyzed Asymmetric Intramolecular Mannich Reaction for the Synthesis of 2‐Aryl‐2,3‐dihydro‐4‐quinolones.
Authors: Mondal Buddhadeb , Pan Subhas Chandra
Published: April 2015

Primary amino acids are found to be efficient catalysts for the direct asymmetric Mannich reaction of 2‐aminoacetoacetophenones with aldehydes furnishing 2‐aryldihydroguinolones (III) (25 examples) in moderate to good yield and good to high enantioselectivities.
ChemInform Abstract: An Expeditious and Metal‐Free Synthetic Route Towards Quinolones, Naphthyridones and Benzonaphthyridones.
Authors: Victor Napoleon John , Muraleedharan Kannoth Manheri
Published: April 2015

The described two‐step reaction proceeds through tandem aza‐Michael addition, SNAr cyclization followed by oxidation with IBX.
ChemInform Abstract: Direct C—H Difluoromethylenephosphonation of Arenes and Heteroarenes with Bromodifluoromethyl Phosphonate via Visible‐Light Photocatalysis.
Authors: Wang Lin , Wei Xiao‐Jing , Lei Wen‐Long , Chen Han , Wu Li‐Zhu , Liu Qiang
Published: April 2015

The first visible‐light‐driven difluoromethylenephosphonation of arenes and hetarenes is presented using diethyl bromodifluoromethylphosphonate as radical precursor in the presence of fac‐Ir(PPy)3 (IRP) as photocatalyst.
ChemInform Abstract: A New Method for Peptide Synthesis in the N→C Direction: Amide Assembly Through Silver‐Promoted Reaction of Thioamides.
Authors: Pourvali Aysa , Cochrane James R. , Hutton Craig A.
Published: April 2015

N‐Protected amino acids (I) undergo an interesting Ag2CO3‐promoted coupling with amino ester thioamides to yield N‐acetylated dipeptides (III) without epimerization.
ChemInform Abstract: A D‐Ribose‐Derived α‐Amino Nitrile as a Versatile Intermediate for the Collective Synthesis of Piperidine‐Type Iminosugar C‐Glycosides.
Authors: Hu Xiang‐Guo , Daryl Ariawan A. , Hunter Luke
Published: April 2015

Treatment of α‐amino nitrile (I) with AgBF4 generates an iminium salt intermediate, which is readily functionalized with Grignard reagents to form C‐glycoside products with excellent stereocontrol.
ChemInform Abstract: Fluevirines A—D (I)‐(III), Four New Securinega‐Type Alkaloids from Flueggea virosa.
Authors: Li Xiao‐Hui , Cao Ming‐Ming , Zhang Yu , Li Shun‐Lin , Di Ying‐Tong , Hao Xiao‐Jiang
Published: April 2015

Fluevirine A (I) exhibits weak antimicrobial activity against Staphylococcus aureus.
ChemInform Abstract: New Alkaloids Sinomacutines A—E, and cephalonine‐2‐O‐β‐d‐glucopyranoside from Rhizomes of Sinomenium Acutum.
Authors: Li Yan‐Hong , Li Hong‐Mei , Li Yan , He Juan , Deng Xu , Peng Li‐Yan , Gao Ling‐Huan , Zhao Qin‐Shi , Li Rong‐Tao , Wu Xing‐De
Published: April 2015

Compounds (I)‐(VI) are evaluated towards their antiinflammatory and cytotoxic activity.
ChemInform Abstract: Two Novel Polycyclic Spiro Lignans from Gymnotheca involucrata.
Authors: Xiao Shi‐Ji , Lei Xin‐Xiang , Xia Bing , Xu Dan‐Qing , Xiao Hong‐Ping , Xu Hong‐Xi , Chen Fang , Ding Li‐Sheng , Zhou Yan
Published: April 2015

Evaluation of the antiviral activity of gymnothespirolignans A (I) and (II) reveals promising activities.
ChemInform Abstract: Preparation of Indolequinones and Their Applications in Organic Synthesis
Authors: Luu Quang H. , Mito Shizue
Published: April 2015

Review: 168 refs.
ChemInform Abstract: Chromium‐Catalyzed Transformations with Grignard Reagents ‐ New Opportunities for Cross‐Coupling Reactions
Authors: Zeng Xiaoming , Cong Xuefeng
Published: April 2015

Review: 53 refs.
ChemInform Abstract: Copper‐Catalyzed C—H Functionalization Reactions: Efficient Synthesis of Heterocycles
Authors: Guo Xun‐Xiang , Gu Da‐Wei , Wu Zhengxing , Zhang Wanbin
Published: April 2015

Review: 178 refs.
ChemInform Abstract: Functionalization of C—H Bonds via Metal‐Catalyzed Desulfitative Coupling: An Alternative Tool for Access to Aryl‐ or Alkyl‐Substituted (Hetero)arenes
Authors: Yuan Kedong , Soule Jean‐Francois , Doucet Henri
Published: April 2015

Review: 134 refs.
ChemInform Abstract: Supramolecular Chemistry
Authors: Wang Kai , Yang Ying‐Wei
Published: April 2015

Review: [mol.
ChemInform Abstract: Applications of Barton‐McCombie Reaction in Total Syntheses
Authors: Heravi Majid M. , Bakhtiari Atefe , Faghihi Zeinab
Published: April 2015

Review: 186 refs.
ChemInform Abstract: Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs
Authors: Alcantara Andres R. , Pace Vittorio , Hoyos Pilar , Sandoval Manuel , Holzer Wolfgang , Hernaiz Maria J.
Published: April 2015

Review: 117 refs.
ChemInform Abstract: Ozone Degradation of Alcohols, Ketones, Ethers and Hydroxybenzenes: Determination of Pathways and Kinetic Parameters
Authors: Rakovsky Slavcho K. , Anachkov Metody P. , Iliev Vesselin I. , Eliyas Alexander E.
Published: April 2015

Review: 94 refs.
ChemInform Abstract: Recent Developments in Two‐Dimensional (2D) Correlation Spectroscopy
Authors: Noda Isao
Published: April 2015

Review: [8 refs.
ChemInform Abstract: Modulating Protein—Protein Interactions: The Potential of Peptides
Authors: Nevola Laura , Giralt Ernest
Published: April 2015

Review: 156 refs.
ChemInform Abstract: Designing Photoswitches for Molecular Solar Thermal Energy Storage
Authors: Lennartson Anders , Roffey Anna , Moth‐Poulsen Kasper
Published: April 2015

Review: 55 refs.
ChemInform Abstract: New Generation Solar Cells: Concepts, Trends and Perspectives
Authors: Ragoussi Maria‐Eleni , Torres Tomas
Published: April 2015

Review: [147 refs.
Crystallin Nanofibrils: A Functionalizable Nanoscaffold with Broad Applications Manufactured from Waste
Authors: Kaur Manmeet , Roberts Sarah , Healy Jackie , Domigan Laura , Vasudevamurthy Madhusudan , Gerrard Juliet A. , Sasso Luigi
Published: April 2015

Protein nanofibrils self‐assembled from crystallin proteins, a waste material from the fishing industry, have been identified as a suitable material to be used as a bionanoscaffold. In this study, a successful method for the functionalization of crystallin protein nanofibrils by immobilizing several enzymes of industrial relevance (glucose oxidase, β‐galactosidase, pectinase, α‐amylase, and laccase) through a glutaraldehyde cross‐linking approach is reported. The extent of functionalization is evaluated by using gel electrophoresis, transmission electron microscopy, and thermostability studies. The functionalized fibrils are investigated further for reusability studies—the use of protein nanofibrils as nanoscaffolds results in a significant increase in enzyme thermostability and reusability relative to the free enzyme in solution under the same conditions. Finally, as an example and proof of concept, the use of the developed functionalization method in a biosensor platform for glucose and lactose detection is shown, by utilizing the crystallin protein nanofibrils as nanoscaffolds.
Fluorescence triggering: A general strategy for enumerating and phenotyping extracellular vesicles by flow cytometry
Authors: Arraud Nicolas , Gounou Céline , Turpin Delphine , Brisson Alain R.
Published: April 2015

Plasma contains cell‐derived extracellular vesicles (EVs) which participate in various physiopathological processes and have potential biomedical applications. Despite intense research activity, knowledge on EVs is limited mainly due to the difficulty of isolating and characterizing sub‐micrometer particles like EVs. We have recently reported that a simple flow cytometry (FCM) approach based on triggering the detection on a fluorescence signal enabled the detection of 50× more Annexin‐A5 binding EVs (Anx5+ EVs) in plasma than the conventional FCM approach based on light scattering triggering. Here, we present the application of the fluorescence triggering approach to the enumeration and phenotyping of EVs from platelet free plasma (PFP), focusing on CD41+ and CD235a+ EVs, as well as their sub‐populations which bind or do not bind Anx5. Higher EV concentrations were detected by fluorescence triggering as compared to light scattering triggering, namely 40× for Anx5+ EVs, 75× for CD41+ EVs, and 15× for CD235a+ EVs. We found that about 30% of Anx5+ EVs were of platelet origin while only 3% of them were of erythrocyte origin. In addition, a majority of EVs from platelet and erythrocyte origin do not expose PS, in contrast to the classical theory of EV formation. Furthermore, the same PFP samples were analyzed fresh and after freeze‐thawing, showing that freeze‐thawing processes induce an increase, of about 35%, in the amount of Anx5+ EVs, while the other EV phenotypes remain unchanged. The method of EV detection and phenotyping by fluorescence triggering is simple, sensitive and reliable. We foresee that its application to EV studies will improve our understanding on the formation mechanisms and functions of EVs in health and disease and help the development of EV‐based biomarkers. © 2015 International Society for Advancement of Cytometry
Monomeric or Dimeric Aluminum Complexes as Catalysts for Cycloaddition between CO2 and Epoxides
Authors: Kim So Han , Han Sang Yeop , Kim Jeong Hee , Kang Yi Young , Lee Junseong , Kim Youngjo
Published: April 2015

A monomeric aluminum complex containing aliphatic tetradentate ligand L1 (HOCMe2CH2NMeCH2CH2NMeCH2CMe2OH) was synthesized and used as a catalyst for cycloaddition between CO2 and epoxides in the presence of PPNCl as a cocatalyst. To check the effect of ligand L1, coordinated to the aluminum center, on the activity of cycloaddition, the new ligand HOCMe2CH2NMe2, which corresponds to half of L1, was systematically designed to make monomeric or dimeric aluminum complexes. Comparison of the catalytic properties of the aluminum complex containing the tetradentate ligand with those of the two related aluminum complexes containing the bidentate ligand under the same conditions revealed that the first system showed higher activity than the other two for cycloaddition between CO2 and epoxides in the presence of PPNCl, which was the best cocatalyst out of the six compounds nBu4PBr, nBu4NCl, nBu4NBr, nBu4NI, DMAP, and PPNCl.
Superior Performance of a MoS2‐RGO Composite and a Borocarbonitride in the Electrochemical Detection of Dopamine, Uric Acid and Adenine
Authors: Pramoda K. , Moses Kota , Maitra Urmimala , Rao C. N. R.
Published: April 2015

A MoS2‐RGO composite and borocarbonitride (BC5N) have been used as electrodes to selectively detect dopamine and uric acid in the presence of ascorbic acid. Both the electrodes show excellent eletrocatalytic activity towards the detection of dopamine, the detection limits being 0.55 μM and 2.1 μM in the case of MoS2‐RGO and BCN respectively. MoS2‐RGO shows a linear range of current over the 1–110 μM concentrations of dopamine, while BCN shows over the 2.3–20 μM range. BCN also exhibits satisfactory performance in the oxidation of uric acid with a detection limit of 3.8 μM and the linear range from 4 to 40 μM. The MoS2‐RGO has also been used to detect adenine as well.
High‐Speed Fabrication of Lithium‐Ion Battery Electrodes by UV‐Curing
Authors: Xue Zheng , Hu Libo , Amine Khalil , Zhang Zhengcheng
Published: April 2015

In this study, UV‐curing was investigated as an alternative method to provide fast production of composite cathodes and significantly reduce the time and energy required for solvent removal in lithium‐ion battery fabrication. To serve our purpose, low‐molecular‐weight polysiloxane acrylate (PSA) was designed and synthesized from a polysiloxane epoxide precursor. In the presence of the acrylic acid additive LiNi1/3Mn1/3Co1/3O2 (NMC), electrode laminates containing 10 wt % PSA binder were successfully fabricated by UV‐curing. The cured electrode exhibited good mechanical and electrochemical properties. At current rates up to C/3, the cell performance of the UV‐cured NMC electrode was comparable to that of conventional polyvinylidene fluoride (PVDF)‐bound NMC electrode. Our initial success in applying high‐speed UV‐curing in composite electrode fabrication has proved that it is a promising route to substantially reducing the capital and operation costs of lithium‐ion battery electrode manufacturing and additionally bringing about important environmental benefits.
Well‐balanced positivity preserving central‐upwind scheme for the shallow water system with friction terms
Authors: Chertock A. , Cui S. , Kurganov A. , Wu T.
Published: April 2015

Shallow water models are widely used to describe and study free‐surface water flow. While in some practical applications the bottom friction does not have much influence on the solutions, there are still many applications, where the bottom friction is important. In particular, the friction terms will play a significant role when the depth of the water is very small. In this paper, we study shallow water equations with friction terms and develop a semi‐discrete second‐order central‐upwind scheme that is capable of exactly preserving physically relevant steady states and maintaining the positivity of the water depth. The presence of the friction terms increases the level of complexity in numerical simulations as the underlying semi‐discrete system becomes stiff when the water depth is small. We therefore implement an efficient semi‐implicit Runge‐Kutta time integration method that sustains the well‐balanced and sign preserving properties of the semi‐discrete scheme. We test the designed method on a number of one‐dimensional and two‐dimensional examples that demonstrate robustness and high resolution of the proposed numerical approach. The data in the last numerical example correspond to the laboratory experiments reported in [L. Cea, M. Garrido, and J. Puertas, Journal of Hydrology, 382 (2010), pp. 88–102], designed to mimic the rain water drainage in urban areas containing houses. Since the rain water depth is typically several orders of magnitude smaller than the height of the houses, we develop a special technique, which helps to achieve a remarkable agreement between the numerical and experimental results. Copyright © 2015 John Wiley & Sons, Ltd.
Novel value‐added uses for sweet potato juice and flour in polyphenol‐ and protein‐enriched functional food ingredients
Authors: Grace Mary H. , Truong An N. , Truong Van‐Den , Raskin Ilya , Lila Mary Ann
Published: April 2015

Blackcurrant, blueberry, and muscadine grape juices were efficiently sorbed, concentrated, and stabilized into dry granular ingredient matrices which combined anti‐inflammatory and antioxidant fruit polyphenols with sweet potato functional constituents (carotenoids, vitamins, polyphenols, fibers). Total phenolics were highest in blackcurrant‐orange sweet potato ingredient matrices (34.03 mg/g), and lowest in muscadine grape‐yellow sweet potato matrices (10.56 mg/g). Similarly, anthocyanins were most concentrated in blackcurrant‐fortified orange and yellow sweet potato matrices (5.40 and 6.54 mg/g, respectively). Alternatively, other protein‐rich edible matrices (defatted soy flour, light roasted peanut flour, and rice protein concentrate) efficiently captured polyphenols (6.09–9.46 mg/g) and anthocyanins (0.77–1.27 mg/g) from purple‐fleshed sweet potato juice, with comparable efficiency. Antioxidant activity correlated well with total phenolic content. All formulated ingredient matrices stabilized and preserved polyphenols for up to 24 weeks, even when stored at 37°C. Complexation with juice‐derived polyphenols did not significantly alter protein or carbohydrate profiles of the matrices. Sensory evaluation of the ingredient matrices suggested potential uses for a wide range of functional food products.
Prevention of acute exacerbation of chronic hepatitis B infection in cancer patients receiving chemotherapy in a hepatitis B virus endemic area
Authors: Hsu Ping‐I , Lai Kwok‐Hung , Cheng Jin‐Shiung , Kao Sung‐Shuo , Li Yuan‐Rung , Sun Wei‐Chih , Chen Wen‐Chi , Lin Kung‐Hung , Shin Chih‐An , Chiang Po‐Hung , Li Yun‐Da , Ou Wei‐Ting , Chen Hui‐Chun , Yu Hsien‐Chung
Published: April 2015

Reactivation of hepatitis B viral (HBV) infection in cancer patients undergoing chemotherapy may cause interruption of chemotherapy and lead to liver failure and death. In our institute, a computerized order entry–based alert system was introduced in September 2011 to remind healthcare providers of HBV testing when prescribing chemotherapy. Since August 2012, an order entry–based therapeutic control system has been applied to ensure HBV prophylaxis during chemotherapy. This retrospective cohort study included cancer patients receiving chemotherapy in the Kaohsiung Veterans General Hospital from November 2009 to June 2013. The prechemotherapy HBV screening rate, HBV prophylactic rate, and severe HBV acute exacerbation rate were compared between stages with different order systems. Newly diagnosed cancer patients (n = 2512) were included. The HBV testing rate in the screening reminder stage was higher than that in the educational stage (93.5% versus 40.2%, P < 0.001), whereas the adequate HBV prophylactic rates in the two order entry–based stages were comparable (41.1% versus 39.2%). Patients in the order entry–based therapeutic control stage had a higher HBV screening rate (99.3% versus 40.2%, P < 0.001) and a higher HBV prophylactic rate (95.8% versus 39.2%, P < 0.001) than those in the educational stage. Additionally, the severe HBV acute exacerbation rate in the therapeutic control stage was lower than those in the educational and screening reminder stages (0% versus 1.2% and 1.2%, respectively; both P < 0.01). Conclusion: A computerized order entry–based therapeutic control system can provide excellent prechemotherapy HBV screening for cancer patients undergoing chemotherapy and can effectively prevent severe acute exacerbation of HBV infection in hospitals among HBV endemic areas. (Hepatology 2015;62:387–396
The severity of steatosis influences liver stiffness measurement in patients with nonalcoholic fatty liver disease
Authors: Petta Salvatore , Maida Marcello , Macaluso Fabio Salvatore , Di Marco Vito , Cammà Calogero , Cabibi Daniela , Craxì Antonio
Published: April 2015

In nonalcoholic fatty liver disease, the influence of severity of steatosis on liver stiffness measurement (LSM) is poorly studied and still debated. We assessed the impact of steatosis severity and its ultrasonographic (US) sign, severe bright liver echo pattern, on LSM values and on transient elastography accuracy for the diagnosis of liver fibrosis in a cohort of consecutive patients with nonalcoholic fatty liver disease. Patients (n = 253) were assessed by clinical, US, and histological (Kleiner score) features. Transient elastography was performed using the M probe. Among patients with low amounts of fibrosis (F0‐F1 and F0‐F2), median LSM values, expressed in kilopascals, were significantly higher in subjects with severe steatosis (≥66% at liver biopsy) compared to those without (F0‐F1 6.9 versus 5.8, P = 0.04; F0‐F2 7.4 versus 6.0, P = 0.001) as well as in patients with severe bright liver echo pattern on US compared to their counterparts (F0‐F1 7.3 versus 5.6, P = 0.001; F0‐F2 7.6 versus 6.0, P < 0.001). In subjects without significant fibrosis (F0‐F1) and without severe fibrosis (F0‐F2), a higher rate of false‐positive LSM results was observed in patients with steatosis ≥66% compared to those without (F0‐F1 23.6% versus 14.9%, F0‐F2 33.3% versus 13.2%) and in patients with severe bright liver echo pattern on US (F0‐F1 22.2% versus 15.4%, F0‐F2 28.8% versus 15.6%) compared to their counterparts. Conclusions: In patients with nonalcoholic fatty liver disease, the presence of severe steatosis, detected by histology or by US, should always be taken into account in order to avoid overestimations of liver fibrosis assessed by transient elastography. (Hepatology 2015;62:1101‐1110)
HRM Signals for the Capital Market
Authors: Krausert Achim
Published: April 2015

This conceptual study contributes to an emerging literature at the intersection of strategic HRM and finance, which is concerned with the undervaluation of future‐oriented HRM practices in the capital market and consequent disincentives for managers to invest in such HRM practices. More specifically, the study contributes to a search for signals of HRM investments that the capital market either attends to or should attend to. It focuses on potential signals of high‐performance work systems (HPWSs), constituting an HRM investment that has been at the center of research in strategic HRM. Based on signaling theory, a model is proposed of relationships among three signal characteristics (signal fit, signal erosion, and signal diffusion) and sustainable signal correlation. The model provides a basis for the exploration of alternative strategies for the establishment of an HRM signal tailored specifically to the needs of the capital market. © 2015 Wiley Periodicals, Inc.
The Impact of Management Development Practices on Organizational Commitment
Authors: Cao Jie , Hamori Monika
Published: April 2015

Social exchange theorists argue that organizations that provide developmental assignments raise employee commitment. But such assignments may also undermine commitment by increasing the recipients’ value in the external labor market. We compare the effect of developmental assignments on organizational commitment with that of other development practices: coaching, mentoring, training, and support from the direct superior and senior management. We also test whether synergies arise when developmental assignments are combined with the other development practices. Using a sample of 312 highly skilled professionals working in over sixty countries, in a variety of industries and firms of various sizes, we find that developmental assignments are the strongest driver of organizational commitment, together with support from senior management. The positive relationship between developmental assignments and organizational commitment is weaker in the presence of other development practices. © 2015 Wiley Periodicals, Inc.
NF‐κB and stat3 transcription factor signatures differentiate HPV‐positive and HPV‐negative head and neck squamous cell carcinoma
Authors: Gaykalova Daria A. , Manola Judith B. , Ozawa Hiroyuki , Zizkova Veronika , Morton Kathryn , Bishop Justin A. , Sharma Rajni , Zhang Chi , Michailidi Christina , Considine Michael , Tan Marietta , Fertig Elana J. , Hennessey Patrick T. , Ahn Julie , Koch Wayne M. , Westra William H. , Khan Zubair , Chung Christine H. , Ochs Michael F. , Califano Joseph A.
Published: April 2015

Using high‐throughput analyses and the TRANSFAC database, we characterized TF signatures of head and neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis of target gene expression, correcting for the effects of DNA methylation and copy number. Using this discovery pipeline, we determined that human papillomavirus‐related (HPV+) and HPV− HNSCC differed significantly based on the activity levels of key TFs including AP1, STATs, NF‐κB and p53. Immunohistochemical analysis confirmed that HPV− HNSCC is characterized by co‐activated STAT3 and NF‐κB pathways and functional studies demonstrate that this phenotype can be effectively targeted with combined anti‐NF‐κB and anti‐STAT therapies. These discoveries correlate strongly with previous findings connecting STATs, NF‐κB and AP1 in HNSCC. We identified five top‐scoring pair biomarkers from STATs, NF‐κB and AP1 pathways that distinguish HPV+ from HPV− HNSCC based on TF activity and validated these biomarkers on TCGA and on independent validation cohorts. We conclude that a novel approach to TF pathway analysis can provide insight into therapeutic targeting of patient subgroup for heterogeneous disease such as HNSCC.
The Nature of Selected English Teachers' Online Participation
Authors: Rodesiler Luke
Published: April 2015

This article documents an investigation into the nature of selected secondary English teachers’ online participation across platforms (i.e., blogs, microblogs, social networking sites) as they explored issues related to teaching, learning, and literacy. Ethnographic content analysis of online artifacts generated over approximately 10 months revealed four interrelated participatory practices that reflect the nature of the teachers’ online participation: supporting teachers, seeking support, curating ideas and information, and promoting one's own online content. With implications for teacher education and future research, the study contributes to growing understandings of teachers’ efforts to advance their professional development by participating online.
Impaired aquaporins expression in the gastrointestinal tract of rat after mercury exposure
Authors: Bottino Cinzia , Vázquez Marta , Devesa Vicenta , Laforenza Umberto
Published: April 2015

The main route of exposure to mercury in humans is through the diet. Consequently, the gastrointestinal mucosa is exposed to the mercurial forms, where they cause intestinal fluid accumulation, mucosal injuries and diarrhea. The relationship between inorganic mercury (HgCl2) and methylmercury (CH3HgCl) exposure and water movement in the gastrointestinal tract is still unexplored. The leading role of aquaporins (AQPs) in the rapid bidirectional movement of fluid in the gastrointestinal tract of mammals is well established. The present study evaluates the effect of HgCl2 and CH3HgCl exposure on AQP expression in different portions of the gastrointestinal tract of rats treated by gavage (5 mg kg–1 of mercury species, single dose, 4 days). The results show that mercury species reduce mRNA and protein levels of AQPs in different parts of the gastrointestinal tract. In the stomach, treated rats show a significant reduction of expression of AQP3 (80–90% for mRNA and 50% for protein) and AQP4 (95–99% for mRNA and 20–40% for protein). In the small and large intestine, treated rats experience a significant reduction of AQP3 and AQP7 expression. Protein contents of both AQPs are reduced in similar proportions in jejunum (AQP3: 40–50%; AQP7: 45–50%) and colon (AQP3: 35–40%; AQP7: 45–60%), regardless of the treatment. Our results indicate that some AQPs are downregulated in the rat gastrointestinal tract by mercury exposure, suggesting a possible role of AQPs in the development of mercury gastrointestinal symptoms. Copyright © 2015 John Wiley & Sons, Ltd.
Aging Leads to a Dysregulation in Mechanically Driven Bone Formation and Resorption
Authors: Razi Hajar , Birkhold Annette I , Weinkamer Richard , Duda Georg N , Willie Bettina M , Checa Sara
Published: April 2015

Physical activity is essential to maintain skeletal mass and structure, but its effect seems to diminish with age. To test the hypothesis that bone becomes less sensitive to mechanical strain with age, we used a combined in vivo/in silico approach. We investigated how maturation and aging influence the mechanical regulation of bone formation and resorption to 2 weeks of noninvasive in vivo controlled loading in mice. Using 3D in vivo morphometrical assessment of longitudinal microcomputed tomography images, we quantified sites in the mouse tibia where bone was deposited or resorbed in response to controlled in vivo loading. We compared the (re)modeling events (formation/resorption/quiescent) to the mechanical strains induced at these sites (predicted using finite element analysis). Mice of all age groups (young, adult, and elderly) responded to loading with increased formation and decreased resorption, preferentially at high strains. Low strains were associated with no anabolic response in adult and elderly mice, whereas young animals showed a strong response. Adult animals showed a clear separation between strain ranges where formation and resorption occurred but without an intermediate quiescent “lazy zone”. This strain threshold disappeared in elderly mice, as mechanically induced (re)modeling became dysregulated, apparent in an inability to inhibit resorption or initiate formation. Contrary to what is generally believed until now, aging does not shift the mechanical threshold required to initiate formation or resorption, but rather blurs its specificity. These data suggest that pharmaceutical strategies augmenting physical exercise should consider this dysfunction in the mechanical regulation of bone (re)modeling to more effectively combat age-related bone loss. © 2015 American Society for Bone and Mineral Research.
Colorectal Cancer Metastases Settle in the Hepatic Microenvironment Through α5β1 Integrin
Authors: Pelillo Chiara , Bergamo Alberta , Mollica Hilaria , Bestagno Marco , Sava Gianni
Published: April 2015

Colorectal cancer (CRC) metastasis dissemination to secondary sites represents the critical point for the patient's survival. The microenvironment is crucial to cancer progression, influencing tumour cell behaviour by modulating the expression and activation of molecules such as integrins, the cell‐extracellular matrix interacting proteins participating in different steps of the tumour metastatic process. In this work, we investigated the role of α5β1 integrin and how the microenvironment influences this adhesion molecule, in a model of colon cancer progression to the liver. The culture medium conditioned by the IHH hepatic cell line, and the extracellular matrix (ECM) proteins, modulate the activation of α5β1 integrin in the colon cancer cell line HCT‐116, and drives FAK phosphorylation during the process of cell adhesion to fibronectin, one of the main components of liver ECM. In these conditions, α5β1 modulates the expression/activity of another integrin, α2β1, involved in the cell adhesion to collagen I. These results suggest that α5β1 integrin holds a leading role in HCT‐116 colorectal cancer cells adhesion to the ECM through the modulation of the intracellular focal adhesion kinase FAK and the α2β1 integrin activity. The driving role of the tumour microenvironment on CRC dissemination, here detected, and described, strengthens and adds new value to the concept that α5β1 integrin can be an appropriate and relevant therapeutic target for the control of CRC metastases. J. Cell. Biochem. 116: 2385–2396, 2015. © 2015 Wiley Periodicals, Inc.
Lexical Characteristics of Anticipatory and Consummatory Anhedonia in Schizophrenia: A Study of Language in Spontaneous Life Narratives
Authors: Buck Benjamin , Minor Kyle S. , Lysaker Paul H.
Published: April 2015

Objectives

The extent to which anticipatory anhedonia (an important determinant of outcome in schizophrenia) is determined by interpersonal characteristics, cognitive biases, or even artifacts of measurement remains unclear. The present study aims to provide understanding cognitive, affective and phenomenological characteristics of this construct by examining the lexical characteristics of life narratives with schizophrenia with computerized lexical analysis.

Method

A total of 41 individuals with a diagnosis of schizophrenia or schizoaffective disorder completed the Indiana Psychiatric Illness Interview, and the lexical characteristics of these narratives were examined for their relationships to both anticipatory and consummatory anhedonia.

Results

Results revealed that relatively higher levels of both anticipatory and consummatory anhedonia were linked with fewer past‐related words and by lesser use of first‐person plural pronouns.

Conclusions

This may suggest anhedonia is linked to diminished access to past narrative episodes and a lesser sense of shared important moments with others.
RETRACTED: Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury‐Induced Lumbar Facet Joint Osteoarthritis
Authors: Kim Jae‐Sung , Ahmadinia Kasra , Li Xin , Hamilton John L. , Andrews Steven , Haralampus Chris A. , Xiao Guozhi , Sohn Hong‐Moon , You Jae‐Won , Seo Yo‐Seob , Stein Gary S. , Van Wijnen Andre J. , Kim Su‐Gwan , Im Hee‐Jeong
Published: April 2015

We report generation and characterization of pain‐related behavior in a minimally invasive facet joint degeneration (FJD) animal model in rats. FJD was produced by a non‐open percutaneous puncture‐induced injury on the right lumbar FJs at three consecutive levels. Pressure hyperalgesia in the lower back was assessed by measuring the vocalization response to pressure from a force transducer. After hyperalgesia was established, pathological changes in lumbar FJs and alterations of intervertebral foramen size were assessed by histological and imaging analyses. To investigate treatment options for lumber FJ osteoarthritis‐induced pain, animals with established hyperalgesia were administered with analgesic drugs, such as morphine, a selective COX‐2 inhibitor, a non‐steroidal anti‐inflammatory drug (NSAID) (ketorolac), or pregabalin. Effects were assessed by behavioral pain responses. One week after percutaneous puncture‐induced injury of the lumbar FJs, ipsilateral primary pressure hyperalgesia developed and was maintained for at least 12 weeks without foraminal stenosis. Animals showed decreased spontaneous activity, but no secondary hyperalgesia in the hind paws. Histopathological and microfocus X‐ray computed tomography analyses demonstrated that the percutaneous puncture injury resulted in osteoarthritis‐like structural changes in the FJs cartilage and subchondral bone. Pressure hyperalgesia was completely reversed by morphine. The administration of celecoxib produced moderate pain reduction with no statistical significance while the administration of ketorolac and pregabalin produced no analgesic effect on FJ osteoarthritis‐induced back pain. Our animal model of non‐open percutanous puncture‐induced injury of the lumbar FJs in rats shows similar characteristics of low back pain produced by human facet arthropathy. J. Cell. Physiol. 9999: 2837–2847, 2015. © 2015 Wiley Periodicals, Inc.
Clinical applications of dual‐channel transmit MRI: A review
Authors: Brink Wyger M. , Gulani Vikas , Webb Andrew G.
Published: April 2015

This article reviews the principle of dual‐channel transmit MRI and highlights current clinical applications which are performed primarily at 3 Tesla. The main benefits of dual‐channel transmit compared with single‐transmit systems are the increased image contrast homogeneity and the decreased scanning time due to the more accurate local specific absorption ratio estimation, meaning that less conservative safety limits are needed. The dual‐transmit approach has been particularly beneficial in body imaging applications, and is also promising in terms of cardiac, spine, and fetal imaging. Future advances in transmit SENSE, the combination of dual‐channel transmit with high permittivity pads, as well as the potential increase in the number of transmit channels are also discussed. J. Magn. Reson. Imaging 2015;42:855–869.