bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding normal progress in pregnancy and the postnatal period
Authors: Lindsay Pat
Published: May 2019

Most women experience normal progress in pregnancy and recovery after the birth is usually uneventful. However, in a few cases, complications may arise. Maternity support workers (MSWs) are in frequent contact with childbearing women and are in a good position to observe their health and hear their concerns.

The midwife responsible for the woman's care can then be alerted at an early stage. While MSWs do not make clinical assessments or diagnoses, an understanding of how pregnancy and postnatal recovery normally progress can help them to identify when problems may be arising. This allows
Bioidentical hormone replacement therapy: implications for practice
Authors: Dilks Aly , Soos Emma
Published: May 2019

In recent years, there has been a cultural shift towards greater acknowledgement of the effects of menopause on women's health, wellbeing and their relationships at both work and home, and an awareness of the very acute need for these symptoms to be monitored and addressed holistically as and when they change. No longer is it accepted that women should just ‘get on with it’, or feel helpless that there are few resources available to help them. As a result, there has been an increase in interest in bio-identical hormone replacement therapy (BHRT), especially following a greater media coverage of celebrities who have shared their own personal stories of this treatment. This has created a snowball effect, resulting in specialist clinics receiving an influx of new patients seeking cohesive and comprehensive advice. This article aims to explore some of the current advice relating to menopause and in particular the difference between HRT and BHRT. The authors will explore how this can impact the role of the aesthetic practitioner in supporting patients with symptoms relating to the menopause effectively.
Taking time to reflect
Authors: Mather Linda , Barker Sarah , Senior Yvonne
Published: May 2019

Taking the time to meet with peers to discuss issues and reflect on practice is an essential part of continuing professional development. PIAPA is committed to holding opportunities for such reflection. In this article, Yvonne Senior, Linda Mather and Sarah Barker discuss some of the recent opportunities to do just that, hosted by PIAPA
When disaster strikes: how to ensure business continuity
Authors: Bernstein Adam
Published: May 2019

Businesses that fail to plan ahead in case of disasters are leading themselves down the path of planned failure, says Adam Bernstein
Managing common end-of-life cancer presentations according to the evidence
Authors: Hart Jasmine , Phillips Peter
Published: May 2019

The ambulance service is increasingly being called to patients suffering from cancer who are near the end of their lives. This presents challenges to clinicians who may not be confident in the management of symptoms near the end of life. The approach to, and management of, these types of patients often requires different considerations to more traditional emergency calls. This article reviews the evidence around the management of common cancer presentations at the end of life. In particular, it will consider the psychological effects of a terminal diagnosis, management of breakthrough pain, breathlessness and neutropenic sepsis.
World War I first aid and ambulance transportation
Authors: Palmer Sarah Jane
Published: May 2019

Painting and text by Sarah Jane Palmer
Fibonacci numbers and resolutions of domino ideals
Authors: BOUCHAT Rachelle  R. , BROWN Tricia Muldoon
Published: May 2019

This paper considers a class of monomial ideals, called domino ideals, whose generating sets correspond to the sets of domino tilings of a $2\times n$ tableau. The multi-graded Betti numbers are shown to be in one-to-one correspondence with equivalence classes of sets of tilings. It is well-known that the number of domino tilings of a $2\times n$ tableau is given by a Fibonacci number. Using the bijection, this relationship is further expanded to show the relationship between the Fibonacci numbers and the graded Betti numbers of the corresponding domino ideal.
A presença de Roma no Oriente: Iudaea Capta e as tradições culturais da Palaestina Romana
Authors: Teixeira-Bastos Marcio , Funari Pedro Paulo Abreu
Published: May 2019

O artigo analisa a ocupação imperialista romana no Oriente Antigo, a consequente dominação da Iudea e sua transformação em Syria Palaestina. Aborda o debate actual sobre o tema, ilustrando também a temática com alguns exemplos da Arqueologia. A demografia e a paisagem da região são tratadas com o objetivo de demonstrar a intersecção de forças externas e de forças internas que definiram os campos de ação nesse inter-fluxo de relações humanas. Argumenta que a adequada administração imperial romana, a organização de uma rede de estradas ordenadas e um sistema de tráfego eficiente, permitiram tanto a mobilidade militar, bem como a formação de estratégias de suprimento, comunicação e controle da região pela população. Salienta categorias de análise, tais como poder, hegemonia, dominação e resistência, para a discussão do tema, afirmando que a formação dos espaços é inerente ao entendimento do próprio conceito de espaço, a esfera da simultaneidade, co-formador do tecido social e das relações de poder. A negociação, nesse sentindo, enquanto categoria analítica é o que fomenta espaços, alimenta as práticas materiais, subsidia as identidades e media o poder. Por fim, o artigo evidencia a importância da contextualidade social, dos contextos arqueológicos e dos contextos de produção dos discursos, como ferramentas próprias para abordagens académicas que privilegiem a percepção das distintas condições ideológicas e contradições inerentes às interações sociais e materiais em contato.
Food and Paremiology in Modern Portugal: “The guest and the fish at three days stink”
Authors: Braga Isabel Drumond
Published: May 2019

The present paper aims to answer the question, how fish was understood and represented, in its literal and figurative senses, in the Portuguese proverbs corpus of the Modern Age, namely in the compilations of Antonio Delicado (1651) and Rafael Bluteau (1712-1728). The foods presents several nutritional qualities and also symbolic values, in such a way that there was always a hierarchy of consumptions related directly to the rarity and the price of the foods, making clear that certain expenditures were socially prestigious. For this purpose, all the proverbs contained in the mentioned sources were collected, analyzed, taking into account the Portuguese context of the Modern Age. Some comparisons considered pertinent were done.The result of the research was an innovative approach to proverbs as a historical source, demonstrating that the choice and use of fish, like any other food, evidences available natural resources, economic power and identity practices of the Portuguese society of the Modern Age. In this sense, fish was associated with eating habits that were part of a cultural system plenty of symbols and meanings capable of determining what, when and how a product was made or not eatable.
MUITO ALÉM DAS CURVAS: A EXPERIÊNCIA DE CONSUMO DAS MULHERES BRASILEIRAS PLUS SIZE NO VAREJO DE MODA
Authors: Scussel Fernanda Bueno Cardoso , Camatini Suele , Rezende Bernardete Cristina , Petroll Martin De La Martinière
Published: May 2019

Considerando a crescente relevância do papel estratégico da perspectiva experiencial para as organizações, este artigo investiga o conceito de experiência de consumo sob a ótica das consumidoras de moda plus size. Trata-se de uma pesquisa qualitativa, na qual foram realizadas 22 entrevistas em profundidade. Os resultados foram analisados utilizando análise de conteúdo temática, resultando em cinco categorias temáticas: experiência pré-consumo, experiência de compra, experiência com o produto, experiência com a moda plus size e consequências da experiência de consumo. Dentre os principais achados, destacam-se a urgência de adequação da oferta de itens do vestuário condizentes com as necessidades físicas e psicológicas deste público, a influência das atitudes dos vendedores e da ambientação dos estabelecimentos comerciais, o fortalecimento da moda plus size e os impactos na autoestima e aceitação que a experiência de consumo proporciona às mulheres acima do peso. Como resultado central, a identificação de cinco dimensões da experiência de consumo para o segmento de moda plus size configura um ponto de partida útil para a realização de futuras investigações e para o avanço teórico-empírico sobre o tema.
RENDIMENTO ACADÊMICO E OS ESTILOS DE APRENDIZAGEM: UM ESTUDO NA DISCIPLINA ANÁLISE DE CUSTOS
Authors: Borges Lara Fabiana Morais , Leal Edvalda Araujo , Silva Taís Duarte , Pereira Janser Moura
Published: May 2019

O objetivo foi verificar se o estilo de aprendizagem impacta no rendimento acadêmico nas avaliações formativas e somativas dos alunos que cursaram a disciplina de Análise de Custos, no curso de Ciências Contábeis. Oportunamente, comparou-se a associação do rendimento na disciplina citada e o rendimento do aluno no semestre, e também no coeficiente geral do curso. Para a análise do rendimento acadêmico utilizou-se a Teoria da Avaliação. Para a coleta de dados, utilizou-se o instrumento proposto por Felder e Soloman (1991), que possibilitou mensurar o estilo de aprendizagem. Para a análise dos dados utilizou-se estatística descritiva, e o teste de Wilcoxon. A amostra compreende 111 alunos matriculados no segundo semestre do ano de 2015 e primeiro semestre de 2016, representando 88% da população. Os resultados apontam a predominância dos estilos ativo, sensorial, visual e sequencial. Quanto ao rendimento acadêmico, verificaram-se maiores médias para as avaliações individuais (somativas). Na comparação do rendimento e os estilos de aprendizagem dos alunos, identificou-se um equilíbrio nas dimensões, ou seja, as médias são próximas tanto para avaliações individuais quanto em grupo e, também, nas médias do Coeficiente de Rendimento Acadêmico (CRA) semestral e geral. O teste não paramétrico Wilcoxon indicou não haver diferença na maioria dos resultados, com exceção entre a avaliação somativa e estilo sequencial/global.
GESTÃO E QUALIDADE EM SERVIÇOS DAS CERAMISTAS NO VALE DO JEQUITINHONHA
Authors: Silveira Rogério Zanon da , Miguel Marcelo Calderari
Published: May 2019

Este artigo enfatiza o trabalho desenvolvido pelas empreendedoras ceramistas de Padre Paraíso, município localizado na região nordeste do estado de Minas Gerais. O objetivo da pesquisa é avaliar a satisfação dos compradores, consumidores de arte da cerâmica, em relação àqualidade dos produtos e do trabalho das mulheres que produzem e comercializam peças cerâmicas nas estradas e feiras livres do Médio Vale do Rio Jequitinhonha. A metodologia deste estudo possui caráter descritivo e qualitativo, a partir de uma readaptação da abordagem teórico-metodológica Servqual. Os resultados obtidos sugerem que os atributos da qualidade são delineados primordialmente pelas facetas empáticas e tangíveis. Ao final, são discutidas as implicações socioculturais, comerciais e acadêmicas dos resultados obtidos nesse território multifatorial de contrastes.
"Even if You return, Ulysses", oder die Geschichte von der Heimkehr
Authors: Costadura Edoardo
Published: May 2019

In seinem Beitrag untersucht Edoardo Costadura die Transformationen des Heimkehr-Motivs in Literatur und Film der Gegenwart. Gestützt auf ein deutsch-französisches Korpus von Filmen und teils fiktionalen teils autobiographischen Texten, dessen Autoren aus der »heimatlosen Generation« (Martin Hecht) der Jahrgänge zwischen 1955 und 1970 stammen, unterscheidet Vf. zwei Modellierungen von Heimkehr: einen »regressiven« oder »restaurativen« Modus, bei dem die Rückkehr in die Heimat (im Sinne von »Zeit-Heimat«) gelingt oder als möglich erscheint, und einen »progressiven« Modus, bei dem sich die Heimkehr als unmöglich erweist. Es zeigt sich allerdings, dass viele der als »regressiv« eingestuften Heimkehr-Darstellungen ironisch gebrochen sind. Vf. gelangt mithin zum Fazit, dass die »Heimkehr-Storys« der vergangenen 20 Jahre mit je unterschiedlichen Akzentuierungen die Zeitlichkeit der Heimaterfahrung und mithin den fundamentalen Konstruktionscharakter von Heimat verhandeln.
Grenzen der Menschenrechte
Authors: Martinsen Franziska
Published: May 2019

Im derzeitigen Katalog der Menschenrechte fehlt ein zentrales Recht, das Hannah Arendt das »Recht auf Rechte« nennt. Dadurch bleibt vielen Menschen, wenn sie nicht Staatsbürger_innen eines Landes sind, in der nationalstaatlichen Praxis das Recht auf politische Mitgestaltung vorenthalten. 70 Jahre nach der Verabschiedung der Allgemeinen Erklärung der Menschenrechte ist daher eine kritische Revision des Menschenrechtsverständnisses dringend erforderlich. Franziska Martinsen erläutert aus radikaldemokratietheoretischer Perspektive, dass Menschenrechte erst dann, wenn sie weniger als humanitäre denn als originär politische Rechte verstanden werden, ihr ermächtigendes Potenzial weltweit entfalten können.
Popmusik aneignen
Authors: Zuther Dirk
Published: May 2019

Die moderne Popmusik ist im Wesentlichen durch orale Traditionen und selbstbestimmtes Lernen geprägt. Trotz dieser allgemein bekannten Tatsache verengt sich der wissenschaftliche Blick weitgehend immer noch auf strukturalistische Sichtweisen und die Fokussierung auf äußere Faktoren wie Kommerz und massenmediale Verbreitung. Dirk Zuther unternimmt daher den Versuch einer Innenansicht und legt den Zusammenhang zwischen Popmusik und ihren Aneignungsstrategien offen. Das Ergebnis bietet nicht nur Einblicke in die Vielfalt popmusikalisch orientierten Lernens, sondern beleuchtet darüber hinaus Fragen des Zusammenhangs zwischen Gegenstand und Aneignung sowie der sich daraus ergebenden Folgerungen für musikdidaktische Ansätze. Das Interview mit Prof. Dr. Volker Schütz, ehemaliger Vorsitzender des AfS, zur Entwicklung der Didaktik der populären Musik ist ein seltenes Zeitdokument zu einem der wichtigsten Vertreter der musikdidaktischen Diskussion und Neuerung in Westdeutschland.
Europa erneuern!
Authors: Liebert Ulrike
Published: May 2019

In der globalisierten Welt im Umbruch zeigt die Europäische Union Ermüdungserscheinungen. Ökonomische Konflikte und Identitätskrisen zehren an ihrem Selbstverständnis. Die Leitidee des Staatenverbundes als »einer immer engeren Union der Völker Europas« scheint aus der Zeit gefallen, der Rückzug ins Nationale nicht zukunftsfähig. Wenn das Europäische Einigungsprojekt noch Chancen haben soll, muss es neu begründet werden. »Europa erneuern!« soll heißen, eine Vision für das 21. Jahrhundert zu entwickeln, welche euro-skeptische Mythen ebenso wie Wunschbilder entzaubert und Europas Potentiale stärkt. Ulrike Liebert zeigt: Ein Upgrade der Demokratie in der EU ist nötig und die innovative Weiterentwicklung der Konventsmethode möglich, wenn das Leitbild einer transnationalen Europäischen Republik realisiert werden soll.
Interpretaciones de Wittgenstein por marxistas ingleses: una crítica
Authors: Vinten Robert
Published: May 2019

Tanto Perry Anderson como Alex Callinicos y Terry Eagleton han desarrollado un trabajo cultural y filosófico sobresaliente. Sin embargo, los tres han malinterpretado la obra de Ludwig Wittgenstein. La concepción de la filosofía de Wittgenstein no está en tensión con la filosofía marxista en el modo en el que ellos lo sugirieron y Wittgenstein no cometió los errores que le atribuyeron Anderson, Callinicos e Eagleton. Los marxistas se beneficiarían si consideraran más seriamente la obra de Wittgenstein porque ello los ayudaría a comprender más claramente la naturaleza de los problemas epistemológicos y metafísicos como así también los ayudaría a fortalecer y complementar sus propias concepciones de las confusiones filosóficas. En este trabajo examinaré los errores de sus interpretaciones de Wittgenstein y espero también poder proporcionar alguna indicación de las razones por las cuales Wittgenstein es considerado por muchos como el filósofo más importante del siglo XX.
Técnicas empleadas en el estudio de enfermedades gástricas
Authors: Rojas Ruiz Johan E. , González López Jesús A. , Camargo Casallas Luz H.
Published: May 2019

Las enfermedades gástricas pueden incluir trastornos de la digestión que aparecen después de las comidas, estos se incrementan por la inadecuada alimentación y ritmos de vida agitados que impiden un equilibrio gástrico normal. Existen diferentes métodos de monitoreo para el diagnóstico de estas patologías; en este artículo se realizó una revisión de diferentes procedimientos invasivos y no invasivos que brindan herramientas de seguimiento y control de enfermedades motoras gástricas. Se encontró que los métodos invasivos pueden presentar molestias para el paciente, mientras que los no invasivos las evitan, aunque no se encuentran plenamente estandarizados.
Análise de aspectos ecológicos da vegetação como ferramenta indicadora da conservação do entorno de cavernas em Laranjeiras, Sergipe
Authors: Donato Christiane Ramos , Ribeiro Adauto Souza , Oliveira Diogo Gallo , Souto Leandro Sousa
Published: May 2019

O presente estudo propõe a avaliação do estado de conservação do entorno de ambientes cavernícolas utilizando como critérios composição, diversidade, similaridade florística e fitossociologia em um raio de 20 m a partir da entrada de cavernas. Foram analisadas nove áreas de entorno, sendo divididas em duas categorias de acordo com o estágio de sucessão secundária: inicial (n = 7) e tardio (n = 2). Foram registradas 36 espécies, das quais 21 foram classificadas como pioneiras, três como secundárias iniciais e 12 como secundárias tardias. Os fragmentos circundantes de Mata Atlântica encontram-se em sua maioria em estágio sucessional inicial, em contraposição ao estabelecido na legislação vigente. Os resultados deste trabalho poderão subsidiar a implantação de projetos de recuperação da Mata Atlântica existente na área estudada, identificando áreas prioritárias para conservação.
Determinação das propriedades mecânicas das rochas a partir da perfilagem de poços em reservatórios tight sands
Authors: De Jesus Felipe Abreu , Silva José Valdo , Da Silva Ageu Ícaro , Andrade Larissa Renata Santos , Oliveira Murilo de Jesus , Borba Cláudio
Published: May 2019

O conhecimento das propriedades mecânicas das rochas é indispensável no planejamento e execução dos projetos de exploração e produção de petróleo; sendo essas especificações que irão determinar a viabilidade da execução do mesmo. As amostras de testemunhos para obtenção das propriedades mecânicas em testes laboratoriais muitas vezes não são disponíveis. Com o objetivo de resolver este problema, uma série de equações empíricas foi utilizada para estimar essas propriedades, a partir de dados de perfis geofísicos do poço, correlacionando às várias propriedades utilizando diferentes equações. Foi realizado um estudo de caso, utilizando dados de perfilagem fornecidos em arquivo asci, de um poço que atravessou reservatórios do tipo tigth sands gas (reservatórios areníticos de baixa permeabilidade e porosidade). Em seguida foi realizada uma análise quantitativa e qualitativa dos perfis geofísicos, disponíveis (raios gama, densidade sônico), necessários para obtenção da resistência à compressão uniaxial-UCS, ângulo de atrito e coesão, de modo avaliar a resistência da formação. Após todos os dados obtidos, foi utilizado o critério de ruptura de Mohr-Coulomb, observando o comportamento das tensões no reservatório, justificando os valores estimados sobre UCS, coesão e ângulo de atrito, indicando que o reservatório estudado trata-se de uma rocha coesa, dura, compactada, de baixa porosidade, resultando em um poço de baixo risco de produção de areia, e passível de estimulação por faturamento hidráulico.
The role of GFAP and vimentin in learning and memory
Authors: Wilhelmsson Ulrika , Pozo-Rodrigalvarez Andrea , Kalm Marie , de Pablo Yolanda , Widestrand Åsa , Pekna Marcela , Pekny Milos
Published: May 2019

Intermediate filaments (also termed nanofilaments) are involved in many cellular functions and play important roles in cellular responses to stress. The upregulation of glial fibrillary acidic protein (GFAP) and vimentin (Vim), intermediate filament proteins of astrocytes, is the hallmark of astrocyte activation and reactive gliosis in response to injury, ischemia or neurodegeneration. Reactive gliosis is essential for the protective role of astrocytes at acute stages of neurotrauma or ischemic stroke. However, GFAP and Vim were also linked to neural plasticity and regenerative responses in healthy and injured brain. Mice deficient for GFAP and vimentin (GFAP
−/−
Vim
−/−) exhibit increased post-traumatic synaptic plasticity and increased basal and post-traumatic hippocampal neurogenesis. Here we assessed the locomotor and exploratory behavior of GFAP
−/−
Vim
−/− mice, their learning, memory and memory extinction, by using the open field, object recognition and Morris water maze tests, trace fear conditioning, and by recording reversal learning in IntelliCages. While the locomotion, exploratory behavior and learning of GFAP
−/−
Vim
−/− mice, as assessed by object recognition, the Morris water maze, and trace fear conditioning tests, were comparable to wildtype mice, GFAP
−/−
Vim
−/− mice showed more pronounced memory extinction when tested in IntelliCages, a finding compatible with the scenario of an increased rate of reorganization of the hippocampal circuitry.
Finite groups in which every cyclic subgroup is self-normalizing in its subnormal closure
Authors: Qian Guohua
Published: May 2019

For a given prime p, a finite group G is said to be a

𝒞
~

p

{\widetilde{\mathcal{C}}_{p}}

-group if every cyclic p-subgroup of G is self-normalizing in its subnormal closure.
In this paper, we get some descriptions of

𝒞
~

p

{\widetilde{\mathcal{C}}_{p}}

-groups, show that the class of

𝒞
~

p

{\widetilde{\mathcal{C}}_{p}}

-groups is a subgroup-closed formation and that

O

p
′

⁢

(
G
)

{O^{p^{\prime}}(G)}

is a solvable p-nilpotent group for every

𝒞
~

p

{\widetilde{\mathcal{C}}_{p}}

-group G.
We also prove that if a finite group G is a

𝒞
~

p

{\widetilde{\mathcal{C}}_{p}}

-group for all primes p, then every subgroup of G is self-normalizing in its subnormal closure.
Kontrolle bei Übernahmen durch Nicht-EU-Ausländer auch zur Verteidigung von Technologieführerschaft sinnvoll
Authors: Dullien Sebastian
Published: May 2019

There are good economic arguments for preventing non-EU-foreign investors, especially from countries with an incomplete market economy such as China, from taking over or acquiring controlling stakes in European companies with strategic relevance. These arguments apply not only in the context of military relevance or critical infrastructure, but also for some areas in which Europe today has a technological leadership role. In some cases, incomes in Europe can be maximized by preventing technologies and economic clusters to diffuse too quickly globally. However, intervening in cross-border mergers comes with economic costs. Hence, clear rules should be designed to determine whether such mergers and acquisitions should be prohibited, and interventions should be kept to a minimum.
Characterization of Mechanical Properties of 3-D–Printed Materials Using the Asymmetric Four-Point Bending Test and Virtual Fields Method
Authors: Zhou M. M. , He W. , Xie H. M. , Liu S.
Published: May 2019

The virtual fields method (VFM) is an inverse method for characterizing the mechanical properties of materials that has the advantage that all constitutive parameters can be identified using one test. The accuracy of identification is mainly determined by the load configuration, deformation measurement, and virtual displacement fields. In order to promote the use of VFM, a new load configuration for the asymmetric four-point bending (4PB) test is proposed here. A virtual experiment was performed to examine the feasibility of the asymmetric 4PB test, where the configuration of the proposed test was optimized to achieve high identification accuracy. As an example of a practical application, the proposed method combined with moiré interferometry was used to characterize the constitutive parameters of stainless-steel materials fabricated by selective laser-melting 3-D printing. It was demonstrated that this method is suitable for characterizing the material properties of 3-D–printed materials.
GIP-induced vasodilation in human adipose tissue involves capillary recruitment
Authors: Asmar Meena , Asmar Ali , Simonsen Lene , Dela Flemming , Holst Jens Juul , Bülow Jens
Published: May 2019

Glucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increase blood flow and triglyceride clearance in subcutaneous abdominal adipose tissue in lean humans. The present experiments were performed to determine whether the increase involves capillary recruitment. Eight lean healthy volunteers were studied before and after 1 h infusion of GIP or saline during a hyperglycemic–hyperinsulinemic clamp, raising plasma glucose and insulin to postprandial levels. Subcutaneous abdominal adipose tissue blood flow (ATBF) was measured by the 133Xenon clearance technique, and microvascular blood volume was determined by contrast-enhanced ultrasound imaging. During infusion of saline and the clamp, both ATBF (2.7 ± 0.5 mL/min 100 g/tissue) and microvascular blood volume remained unchanged throughout the experiments. During GIP infusion and the clamp, ATBF increased ~fourfold to 11.4 ± 1.9 mL/min 100 g/tissue, P < 0.001. Likewise, the contrast-enhanced ultrasound signal intensity, a measure of the microvascular blood volume, increased significantly 1 h after infusion of GIP and the clamp (P = 0.003), but not in the control experiments. In conclusion, the increase in ATBF during GIP infusion involves recruitment of capillaries in healthy lean subjects, which probably increases the interaction of circulating lipoproteins with lipoprotein lipase, thus promoting adipose tissue lipid uptake.
Implantation failure in rats with subclinical hypothyroidism is associated with LIF/STAT3 signaling
Authors: Shan Ling , Zhou Yingying , Peng Shiqiao , Wang Xinyi , Shan Zhongyan , Teng Weiping
Published: May 2019

Background

Pregnant women with subclinical hypothyroidism are associated with an increased risk of spontaneous abortion. This study aims to investigate the mechanisms underlying the effects of maternal subclinical hypothyroidism during early pregnancy on abortion in the uterus, focusing upon the LIF/STAT3 signaling pathway.

Methods

One hundred five Wistar rats were randomly divided into three groups (35 rats in each group): control (CON) group, subclinical hypothyroidism (SCH) group and overt hypothyroidism (OH) group. We examined the weight of rat uteri, rat placenta and embryos. We also determined the number of implantation sites and the embryo absorption rates. The protein and mRNA expressions of TSHR, TR-α, TR-β, LIFR, gp130, JAK1, p-STAT3 and STAT3 were measured by immunohistochemical staining, real-time PCR and Western blotting.

Results

The weights of rat uteri, rat placenta and embryos were significantly reduced in the SCH and OH groups. The number of implantation sites was significantly decreased in the SCH and OH groups, while embryo absorption rates were significantly increased. The mRNA and protein expressions of TSHR were upregulated in the SCH and OH groups, while TR-α and TR-β showed no difference when compared between the three groups. The expression levels of LIFR, gp130, JAK1 and p-STAT3 were significantly higher in the SCH and OH groups.

Conclusions

Clinical and subclinical hypothyroidism during early pregnancy might cause adverse pregnancy outcomes. Implantation failure in rats with subclinical hypothyroidism was associated with abnormal LIF/STAT3 signaling.
Consideraciones sobre la fenomenología del joven Derrida. A propósito de la edición española de “El problema de la génesis en la filosofía de Husserl”
Authors: Hernández Marcelo Jimmy
Published: May 2019

La presente nota crítica tiene como finalidad exponer y comentar las ideas fundamentales de la edición española del primer escrito de Jacques Derrida, El problema de la génesis en la filosofía de Husserl. Asimismo, hacemos algunas aclaraciones sobre el origen y significado de este escrito. Al concluir, añadimos algunas observaciones sobre la traducción y sobre el estudio final del editor y traductor Javier Bassas Vila sobre la filosofía del joven Derrida.
HIGHER EDUCATION OF SWEDEN: EUROPEAN STANDARDS AND SCANDINAVIAN STYLE
Authors: ZHELANOV DMYTRO
Published: May 2019

The article analyzes certain aspects of the development of higher education in Sweden in the context of modern globalization and integration of socio-economic processes in the countries of the European Union. The article studies the position regarding the features of modern higher education, connected with its output beyond the limits of individual states and transformation into an international institution. It is proved that this circumstance determines significant achievements in the integrated development of the European higher education, leaving, at the same time, the risks of losing its national features and dropping the level of higher education in countries that are not well targeted for the welfare of the population. The necessity of taking into account the essence of these risks has been substantiated in order to increase the competitiveness of Ukrainian higher education institutions in their interrelation and cooperation with universities of Europe. The expediency of studying and introducing the best foreign experience in the national higher education system of the Scandinavian countries in particular and, namely, of Sweden, has been proved.
DETERMINANTS OF THE TEACHER'S PERCEPTION OF STUDENTS AT THE PRIMARY AND SECONDARY SCHOOL LEVEL
Authors: JAKUBCZAK-CHODŹKO MAGDALENA
Published: May 2019

Contemporary tasks and imposed requirements in the area of education are focused on improving the efficiency and quality of teaching, including counteracting the disturbing phenomena of the “day of liquid modernity” [1, p. 15–29]. The teacher's person is perceived subjectively, from the perspective of the contractor of professional assumptions. The dynamics of educational processes and progressive civilization changes forces us to meet the emerging expectations of educational policy. The look of many leading educators, among others Jan Władysław Dawid, Zygmunt Mysłakowski, Wincenty Okoń, Maria Grzegorzewska, Czesław Banach for personality traits of the teacher has gone to oblivion to give way to schematic and mass teaching. Increasingly, attention is paid to how? and not who? teaches. Studies in the field of psychology and pedagogy pose a question; What should the teacher be like? Using the following article, in which I will base myself on empirical research, I want to answer a completely different aspect, what kind of teacher would the students want?
Diverses modalités de traitement des troubles d’apprentissage scolaire par thérapies visuelles: quelles sont les évidences scientifiques?
Authors: Ganivet Amélie , Denault Isabelle , Superstein Rosanne , Fallaha Nicole
Published: May 2019

Les troubles d’apprentissage sont des désordres complexes qui entravent le développement normal des processus d’acquisition et de traitement de l’information. ils sont couramment rencontrés au sein de la population pédiatrique et peuvent se manifester sous diverses formes dont la plus fréquente est la dyslexie. Les troubles d’apprentissage ont une nature chronique et n’ont pas pour cause première des handicaps visuels, auditifs et/ ou moteurs, la déficience intellectuelle, la perturbation affective ni même un milieu défavorisé. Cependant, il est possible que ces troubles puissent coexister avec l’un ou l’autre de ces problèmes.

Puisque les enfants qui en sont atteints rencontrent souvent des difficultés de taille lors des apprentissages fondamentaux dès leur entrée à l’école primaire, il est essentiel de leur offrir un soutien adapté, un diagnostic précoce et une intervention efficace. Plusieurs hypothèses impliquant divers problèmes visuels ont été émises quant à la cause de la dyslexie et des troubles d’apprentissage. La présente revue de littérature traite de ces diverses hypothèses de traitement des troubles d’apprentissage scolaire par thérapies visuelles.

L’analyse démontre qu’il n’y a pas de preuves scientifiques suffisantes à ce jour prouvant que la thérapie visuelle, les lunettes d’entraînement, les exercices de poursuites et de saccades, les exercices perceptuels, les lunettes grossissantes, les filtres ou lentilles colorées ainsi que les prismes peuvent améliorer significativement les troubles d’apprentissage.
Seeing Clearly: A Community-Based Inquiry Into Vision Care Access For a Rural Northern First Nation
Authors: Brise Lindsey S , De Leeuw Sarah
Published: May 2019

There are a variety of barriers to eye-care service access in rural Northern First Nations communities. Semi-structured, opened-ended key informant interviews were conducted on the topic of eye care, with eight First Nations individuals employed by the health office in a small Northern British Columbian First Nations community. Data analysis comprised identifying themes by analyzing similarities and dissimilarities in participants’ narratives, including comparing and contrasting viewpoints of participants and placing themes within broader sociocultural and historic contexts. Themes identified in the data included the current state of community eye care, facilitators and barriers to accessing eye care, and community needs and preferences. The theme of “facilitators and barriers” was further analyzed, resulting in subthemes of awareness, attitudes, social, economic, and service related. Better understanding of the barriers and their interactions would provide a foundation upon which innovative eye-care programs might be developed.
The ‘20/20/20 Rule’ – When Good Intentions and Axiomatic Habit Displace Best Practices
Authors: Boulet Charles
Published: May 2019

Optometrists often proffer the ‘20/20/20 Rule’ as advice for clients who experience nearpoint visual strain, or who are subjected to prolonged exposure to nearpoint devices. The ‘rule’ is offered in the patient’s best interests: To help alleviate asthenopia and visual stress from nearpoint strain, and to reduce the risk of onset or the progression of myopia and associated ocular disease. Best intentions aside, there is a paucity of clinical and scientific support for the rule. On the other hand, modern optical tools and methods, and vision rehabilitation practices are known to be helpful in addressing mild to severe binocular vision disorders, to promote comfort, and to slow the progression of myopia. While offering trite advice to address potentially serious concerns might appear to be helpful, its continued use could well be displacing other more appropriate management strategies. This paper addresses some concerns regarding the promulgation of this well-meaning, but misguided, advice.
Interprofessional Management of Allergic Conjunctivitis
Authors: Prokopich C. Lisa , Lee-Poy Michael , Kim Harold
Published: May 2019

Ocular allergies affect a large and increasing number of people in North America. Canada’s statistics are likely to mirror those of the U.S., where up to 40% of the population is affected by ocular allergies. The symptoms and signs of ocular allergies can greatly affect productivity and have a dramatic effect on overall quality of life (QoL). Over the years, many effective treatments have been developed for the management of ocular allergies. For allergic conjunctivitis, topical ophthalmic agents include antihistamines, mast-cell stabilizers, dual-activity agents, steroids, nonsteroidal anti-inflammatory drugs, and other immune-modulating drugs. Oral antihistamines are commonly chosen by patients for all forms of allergy, including allergic conjunctivitis. This review provides a summary of the forms of ocular allergy, with a particular focus on the symptoms and signs, diagnosis, current treatment options, and impact on QoL. More importantly, through multidisciplinary collaboration, a simplified treatment algorithm is proposed for Canadian clinical practice. This algorithm provides practitioners the best possible management strategies based on an individual patient presentation, thereby maximizing treatment efficacy and minimizing the effects on tasks of daily living and QoL.
Insights for Stratification of Risk in Brugada Syndrome
Authors: Iglesias Daniel García , Rubín José , Pérez Diego , Morís César , Calvo David
Published: May 2019

Brugada syndrome (BrS) is an inherited disease with an increased risk of sudden cardiac death (SCD). However, testing identifies genetic disorders in only 20–30% of patients analysed, indicating a gap in knowledge of its genetic aetiology. Diagnosis relies on ECG, and risk stratification in BrS patients is challenging, primarily because of the complexity of the issue. As a result, clinicians fail to provide the appropriate strategy for SCD prevention for many patients. Several variables and interventions are being studied to improve diagnostics and maximise patient protection. In addition, the scientific community must increase efforts to provide patient care according to knowledge and research for improving stratification of risk. In this article, the authors summarise contemporary evidence on clinical variables and provide an overview of future directions in risk stratification and SCD prevention.
Featuring: Antonio Bayés de Luna
Authors: Bayés de Luna Antonio
Published: May 2019

In the Cardiology Masters section of European Cardiology Review, we bring you an insight into the career of a key contributor to the field of cardiology. In this issue, we feature Professor Antonio Bayés de Luna, Senior Researcher at the Cardiovascular Research Foundation, Cardiovascular ICCC-Program, Research Institute, Hospital de Sant Pau, IIB Sant Pau, Barcelona, Spain.
Developing a framework for teaching clinical reasoning skills to undergraduate physiotherapy students: A Delphi study
Authors: Sole Gisela , Skinner Margot , Hale Leigh , Golding Clinton
Published: May 2019

Students may find it confusing when methods and principles of clinical reasoning vary in different parts of a curriculum. A consistent framework between laboratory and clinical practice, and across the curriculum should be designed to facilitate student learning. The aim of this study was to identify key elements that academic and teaching staff consider to be important for teaching clinical reasoning to undergraduate physiotherapy students at the University of Otago, New Zealand. Educators (n = 41) involved in Year 2 to 4 teaching for at least one academic year across the School of Physiotherapy’s centres and hubs were invited to participate. A Delphi study was used to reach consensus about principles of clinical reasoning. There was consensus that clinical reasoning is an ongoing, complex and systematic process that is both collaborative and interactive. The World Health Organization International Classification of Function was the model considered most relevant for students to both gather and interpret information from the patient, and to plan and apply management. While students are expected to rely mainly on hypothetico-deductive reasoning systems, pattern recognition may develop with integration of theoretical knowledge and clinical practice. This project enabled physiotherapy educators to share information across their different geographical and contextual areas, and to reach consensus about elements considered important for teaching clinical reasoning to undergraduate students.
Expansão e avaliação da área de História - 2010/2016
Authors: Fico Carlos , Wasserman Claudia , Magalhães Marcelo de Souza
Published: May 2019

Este artigo divulga dados sobre o crescimento e avaliação dos programas de pós-graduação em História durante os anos 2010-2016 e sobre o aprimoramento dos instrumentos de avaliação dos livros e periódicos. Apresenta, ainda, uma proposta de mudança da avaliação continuada dos programas de pós-graduação do Brasil.
Os sons do silêncio: interpelações feministas decoloniais à História da historiografia
Authors: Oliveira Maria da Gloria de
Published: May 2019

O artigo propõe uma reflexão acerca dainvisibilidade das produções de autoria femininana história intelectual, tendo por horizonte alguns desafios postos pela perspectiva feminista decolonial. Como ponto de partida, abordo a separação paradigmática que se manifesta nas variadas formas de silenciamento acerca das contribuições intelectuais das mulheres, por conta da persistência de um modelo de pesquisa com foco predominante no estudo dos repertórios canônicos de obras de autoria masculina, branca e europeia. O argumento a ser explorado é o de que a produção de autoria feminina não se configurou como tema privilegiado e frequente da história da historiografia, mantendo-se, em larga medida, como o “outro” silenciado, marginal e periférico nos cânones historiográficos e na memória disciplinar. Por fim, defendo a efetividade da categoria de gênero como aparato conceitual crítico dos fundamentos epistêmicos da disciplina e da escrita da História, tais como a “irrelevância” dos marcadores de sexo, de raça e de classe social do sujeito da operação historiográfica, implícito nos critérios supostamente neutros, objetivos e universais de racionalidade.
Extension of unsaturated soil mechanics and its applications
Authors: Iizuka Atsushi , Tachibana Shinya , Takeyama Tomohide , Sugiyama Yuri , Nomura Shun , Ohta Hideki
Published: May 2019

Although the soil, water and air coupling theory has been deductively derived from the three-phase mixture theory, assumptions and interpretations inherent in soil mechanics are also conveniently introduced in this theory. Mechanical properties of unsaturated soils are phenomenologically integrated into the constitutive equation for a deformation problem, with effective stress expressed as a combination of partial stresses acting on each phase of the mixture. The governing equations of two seepage problems describing the movements of pore water and pore air are formulated by a priori introduction of Darcy’s law. Consequently, the coupling theory consists of a deformation problem and two seepage problems, in which the soil-water retention characteristics play the role of a mediator connecting these problems. If the theoretical structure is clarified in this way, an extension of this theory is easily made. In this paper, the extension of the theory to each of four examples and their performance is demonstrated. The features of settlement caused by absorption of soil water due to vegetation; dissolution, advection and diffusion of substances in groundwater; desaturation and state change due to vaporisation of dissolved gas from pore water; and the liquefaction potential of unsaturated soil are presented.
Akt1-mediated CPR cooling protection targets regulators of metabolism, inflammation and contractile function in mouse cardiac arrest v1
Authors: Li Jing , Zhu Xiangdong , Wang Huashan , Lee Chunpei , Chen Sy-Jou , Qian Yuanyu , Han Mei , Bunny Ryan , G. Beiser David , L. Vanden Hoek Terry
Published: May 2019

Therapeutic hypothermia initiated during cardiopulmonary resuscitation (CPR) in pre-clinical studies appears to be highly protective against sudden cardiac arrest injury. Given the challenges to implementing CPR cooling clinically, insights into its critical mechanisms of protection could guide development of new CPR drugs that mimic hypothermia effects without the need for physical cooling. Here, we used Akt1-deficient mice that lose CPR hypothermia protection to identify hypothermia targets. Adult female C57BL/6 mice (Akt1+/+ and Akt1+/-) underwent 8 min of KCl-induced asystolic arrest and were randomized to receive hypothermia (30 ± 0.5⁰C) or normothermia. Hypothermia was initiated during CPR and extended for 1 h after resuscitation. Neurologically scored survival was measured at 72 h. Other outcomes included mean arterial pressure and target measures in heart and brain related to contractile function, glucose utilization and inflammation. Compared to northothermia, hypothermia improved both 2h mean arterial pressure and 72h neurologically intact survival in Akt1+/+ mice but not in Akt1+/- mice. In Akt1+/+ mice, hypothermia increased Akt and GSK3β phosphorylation, pyruvate dehydrogenase activation, and NAD+ and ATP production while decreasing IκBα degradation and NF-κB activity in both heart and brain at 30 min after CPR. It also increased phospholamban phosphorylation in heart tissue. Further, hypothermia reduced metabolic and inflammatory blood markers lactate and Pre-B cell Colony Enhancing Factor. Despite hypothermia treatment, all these effects were reversed in Akt1+/- mice. Taken together, drugs that target Akt1 and its effectors may have the potential to mimic hypothermia-like protection to improve sudden cardiac arrest survival when administered during CPR.
SYBR® Select Master Mix v1
Authors: Miguel Eduardo Marín Dr , M. Cawthon Richard , Delgadillo Dealmy
Published: May 2019

This quick reference simplified instructions for using the SYBR® Selct Master Mix reagent for performing real-time PCR assay.
Calibration Protocol - OD600 Inter-equipment Conversion with LUDOX v1
Authors: Rutten Paul , Tennant Richard
Published: May 2019

With this protocol you will use LUDOX CL-X (a 45% colloidal silica suspension) as a single point reference to obtain a conversion factor to transform absorbance (OD600) data from your plate reader into a comparable OD600 measurement as would be obtained in a spectrophotometer. This conversion is necessary because plate reader measurements of absorbance are volume dependent; the depth of the fluid in the well defines the path length of the light passing through the sample, which can vary slightly from well to well. In a standard spectrophotometer, the path length is fixed and is defined by the width of the cuvette, which is constant. Therefore this conversion calculation can transform OD600 measurements from a plate reader (i.e. absorbance at 600 nm, the basic output of most instruments) into comparable OD600 measurements. The LUDOX solution is only weakly scattering and so will give a low absorbance value.
Standard iGEM Cell Measurement Protocol v1
Authors: Tennant Richard , Rutten Paul
Published: May 2019

This is a protocol from the 2018 iGEM InterLab study which tests various 'standard' parts from the Registry.
PATERNALİST LİDERLİK VE ÖRGÜT KÜLTÜRÜ İLİŞKİSİ: SAKARYA ÜNIVERSİTESİ ÖRNEĞİ
Authors: KARŞU CESUR Damla , ERKİLET Alev , TAYLAN Hasan Hüseyin
Published: May 2019

Batı
kaynaklı olmayan, şefkat ve otoriteyi birleştiren paternalist liderlik Batılı
araştırmacılar tarafından ön yargı ile değerlendirilmekte ve geleneksellikle ilişkilendirilmektedir.
Hofstede’nin kültürel boyutları bağlamında ise alanda öne çıkan görüş, paternalist
liderliğin belirsizlikten sakınma ve güç aralığı yüksek, dişil ve kollektivist kültürel
boyutların baskın olduğu örgütlerde daha yaygın olabileceğidir. Dolayısıyla
araştırma paternalist liderliği, kültürün söz konusu boyutları bağlamında
sorgular. Araştırma, hem geleneksel hem de Batı yönetim anlayışlarının iç içe
geçtiği varsayılan Sakarya Üniversitesi’nde gerçekleşir. Üniversitenin akademik
ve idari personeline uygulanan anket formları neticesinde ise, çalışanın paternalist
liderlik eğilimi üzerinde bireycilik-kollektivizm, güç aralığı ve
erillik-dişillik boyutlarının etkili olduğu tespit edilir. Bununla birlikte
araştırma katılımcının cinsiyeti ile paternalist liderlik eğilimi arasında da istatistiksel
olarak anlamlı bir ilişkinin bulunduğunu saptar.