bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Shape Optimization of Strain Gauge Load Cell for Axial Force Measurement for Test Benches
Authors: Al-Dahiree Omar Sabah , Tokhi Mohammad Osman , Hadi Nabil Hassan , Hmoad Nassar Rasheid , Ghazilla Raja Ariffin Raja , Yap Hwa Jen , Albaadani Emad Abdullah
Published: September 2022

The load cell is an indispensable component of many engineering machinery and industrial automation for measuring and sensing force and torque. This paper describes the design and analysis of the strain gauge load cell, from the conceptional design stage to shape optimization (based on the finite element method (FEM) technique) and calibration, providing ample load capacity with low-cost material (aluminum 6061) and highly accurate force measurement. The amplifier circuit of the half Wheatstone bridge configuration with two strain gauges has been implemented experimentally with an actual load cell prototype. The calibration test was conducted to evaluate the load cell characteristics and derive the governing equation for sensing the unknown load depending on the measured output voltage. The measured sensitivity of the load cell is approximately 15 mV/N and 446.8 µV/V at a maximum applied load of 30 kg. The findings are supported by FEM results and experiments with an acceptable percentage of errors, which revealed an overall error of 6% in the worst situation. Therefore, the proposed load cell meets the design considerations for axial force measurement for the laboratory test bench, which has a light weight of 20 g and a maximum axial force capacity of 300 N with good sensor characteristics.
Notes on Prerequisites of Loop Quantum Gravity
Authors: Vyas Rakshit , Joshi Mihir
Published: September 2022

Loop quantum gravity (LQG) quantizes gravity through the quantization of the space-time. It begins with general relativity (GR) and brings some concepts from quantum field theory to quantize the space-time. The conceptual background of GR is necessary to comprehend the LQG framework. Therefore, in this paper, prerequisite concepts such as special relativity, general relativity, covariant electromagnetism, tensor analysis, Lagrangian formulation, Hamiltonian formulation and basics of quantum mechanics are briefly introduced; that, are needed to study loop quantum gravity(LQG).
Difusão da ISO 9001: 2015 em organizações de P&D
Authors: Pinheiro Costa Gaio Arnaldo , Pereira Eufrazio Edilvando
Published: September 2022

Apesar de existirem estudos de caso sobre o sistema de gestão da qualidade em centros de pesquisa – chamados aqui de organizações de P&D – nenhum desses estudos objetivava apresentar a difusão da certificação ISO 9001:2015 nesse grupo. Nesse sentido, mesmo no “The ISO Survey” não se tem evidências em relação à difusão da ISO 9001:2015 em organizações de P&D. O objetivo deste artigo é analisar a difusão da ISO 9001:2015 em organizações de P&D, incluindo seus escopos. Utilizando dados fornecidos por diferentes bancos de dados, foi possível encontrar casos a serem estudados e construir um novo banco de dados. Além disso, a revisão dos escopos do sistema de gestão da qualidade, com base na ISO 9001: 2015, permitiu caracterizá-los. A base de dados criada possibilitou entender a difusão da ISO 9001 e os objetos das certificações pelas organizações de P&D ao redor do mundo. O presente artigo tenta ser uma contribuição relevante para se compreender a ISO 9001: 2015 em organizações de P&D e a importância dessa certificação neste tipo de organização.
Palavras-chave: ISO 9001; P&D; Sistema de Gestão da Qualidade; Organização de P&D.
Use of a 3D Model for the Correction of a Complex Madelung Deformity in a Teenager
Authors: Catena Nunzio , Arrigoni Chiara , Origo Carlo
Published: September 2022

Case:

The aim of the article is to report on a case of a teenager affected by Madelung deformity treated with a double osteotomy, planned by means of a 3D model. Using a custom-made cutting guide, the radial osteotomy was performed, and after the reorientation, a shortening ulnar osteotomy completed the procedure. Postoperative clinical assessment showed a normal alignment of the ulna with increased range of motion wrist motion.

Conclusions:

Using a 3D model when planning a multidirectional correction of a Madelung deformity may be advantageous to achieve a more accurate and precise realignment of the carpus and distal radioulnar joint.
Supratherapeutic Antibiotic Levels and Acute Kidney Injury from Absorption of Topical Antibiotics
Authors: Schmitz Michael W. , Wojahn Robert D.
Published: September 2022

Case:

A 96-year-old woman with no baseline renal dysfunction presented with a distal femoral shaft fracture after a ground-level fall. Treatment was with a retrograde intramedullary nail and included placement of topical antibiotics. Postoperatively, she developed acute kidney injury and was found to have supratherapeutic antibiotic levels.

Conclusion:

This case report demonstrates the risk of clinically relevant systemic absorption along with associated downstream end organ damage with the use of topical antibiotics in certain circumstances. We present this case as an illustration of a rare hazard associated with topical antibiotic use.
Stemless Hemiarthroplasty and Anterior Capsular Reconstruction in the Setting of a Residual Humeral Limb
Authors: Park Hannah , Jenkins Sabrina , Stetler Phillip , Baker Matthew C. , Srikumaran Uma
Published: September 2022

Case:

We present a 58-year-old left hand–dominant woman with right glenohumeral osteoarthritis and anterior instability in the setting of a congenital residual limb at the level of the mid-humerus. She had persistent pain and dysfunction despite trying conservative treatments and elected for a stemless or “canal-sparing” hemiarthroplasty with anterior capsular reconstruction. At the 2-year follow-up, there was significant improvement in her pain, motion, and function without signs of radiographic loosening.

Conclusion:

A stemless humeral implant is a versatile component that can be used in the face of humeral dysplasia, such as this patient with a congenital residual limb.
Four economic principles of just sustainability transition
Authors: Dombi Mihály , Fahid Aldebei Faisal Mohammad , Harazin Piroska , Karcagi-Kováts Andrea , Cao Zhi
Published: September 2022

Equitable income distribution is desirable for moral, economic, and social reasons. Recent studies, however, indicate that improved income allocation will result in increased environmental impacts due to our socio-economic system's current settings. Therefore, we explored the key aspects of a system that can more evenly reallocate natural and economic resources while reducing negative environmental impacts. We found that the capital is extremely important as a means of material flows and stocks. Thus, effective policy interventions should target mechanisms at this very market. Based on a comprehensive literature review and statistical analyses at various levels, we proposed a four-step policy framework that includes reducing and targeted savings, reshaping governments' spatial decisions and role in the housing market, and changing the rates of depreciation in income tax legislation used globally. Author summary Over the last decade, there has been an increasing emphasis on economic inequality in the sustainability discourse. Inequality in wealth and earnings evokes social tensions and keeps holding back the efforts towards a just and sustainable society. However, recent studies show, that we cannot reach an aim of a more equal society and decreased pollution and natural resource use in the same time. We discovered that the capital market is extremely important with regard to the connections between the society and its effect on Nature. As a result, a fundamental intervention should attempt to considerably reshape this laxer of the economy in order to address the various problems of our ecological crisis and the inequality issue that it entails. However, a disruption in the capital market would cause substantial social damage, such as shortage on the housing market or through the discontinuation of innovations. The aim, then, is to identify selective yet market-oriented regulatory instruments. Our findings propose a four-step policy framework which fits the requirements above.
Power Allocation Algorithms for Massive MIMO Systems with Multi-Antenna Users
Authors: Bobrov Evgeny , Chinyaev Boris , Kuznetsov Viktor , Minenkov Dmitrii , Yudakov Daniil
Published: September 2022

Modern 5G wireless cellular networks use massive multiple-input multiple-output (MIMO) technology. This concept entails using an antenna array at a base station to concurrently service many mobile devices that have several antennas on their side. In this field, a significant role is played by the precoding (beamforming) problem. During downlink, an important part of precoding is the power allocation problem that distributes power between transmitted symbols. In this paper, we consider the power allocation problem for a class of precodings that asymptotically work as regularized zero-forcing. Under some realistic assumptions, we simplify the sum spectral efficiency functional and obtain tractable expressions for it. We prove that equal power allocation provides optimum for the simplified functional with total power constraint (TPC). Also, low-complexity algorithms that improve equal power allocation in the case of per-antenna power constraints (PAPC) are proposed. On simulations using Quadriga, the proposed algorithms show a significant gain in sum spectral efficiency while using a similar computing time as the reference solutions.
A general interfacial-energetics-tuning strategy for enhanced artificial photosynthesis
Authors: Liu Tian , Pan Zhenhua , Kato Kosaku , Vequizo Junie , Yanagi Rito , Zheng Xiaoshan , Yu Weilai , Yamakata Akira , Chen Baoliang , Hu Shu , Katayama Kenji , Chu Chiheng
Published: September 2022

The demands for cost-effective solar fuels have triggered extensive research in artificial photosynthesis, yet the efforts in designing high-performance particulate photocatalysts are largely impeded by inefficient charge separation. Because charge separation in a particulate photocatalyst is driven by asymmetric interfacial energetics between its reduction and oxidation sites, enhancing this process demands nanoscale tuning of interfacial energetics on the prerequisite of not impairing the kinetics and selectivity for surface reactions. In this study, we realized this target with a general strategy involving the application of a core/shell type cocatalyst that is demonstrated on various photocatalytic systems. Particularly, this strategy was highlighted on a BiVO4 system for overall H2O2 photosynthesis. A core/shell type Ag/Pd cocatalyst was selectively deposited on the reduction facets of BiVO4, where the Ag core formed a low Schottky barrier with BiVO4 at its reduction site for enhancing charge separation and Pd shell preserved the surface kinetics and selectivity for H2O2 generation. Time-resolved spectroscopy and numerical simulations suggest the BiVO4/Ag junction enhanced the asymmetric interfacial energetics as expected. With successful interfacial energetics tuning, BiVO4 exhibits high overall H2O2 photosynthesis among inorganic photocatalysts, with an apparent quantum yield (AQY) of 3.0% and a solar-to-H2O2 conversion (STH) efficiency of 0.73% at full spectrum, as well as an AQY of 13.1% at 420 nm. The promising H2O2 generation efficiency validated our perspective on tuning interfacial energetics for enhanced charge separation and photosynthesis performance.
Studying Vaccination Coverage and Design of Short Message Service Based Reminder to Improve Children Vaccination Coverage in Hawassa; Sidama Region; Ethiopia
Authors: Yenealem Tamirat , Hurissa Dejene
Published: September 2022

A vaccine is a kind of remedy that trains the body’s protection system so that it can combat infection. The national routine immunization coverage in Ethiopia is low. Among the main reason for defaulting children’s vaccinations are disremembering the appointment date, communication gap between service providers and the community, knowhow about vaccination and etc. This work is to investigate vaccination coverage in Hawassa city and the main reasons for vaccination dropout, and then provide a solution for that main reason. Data was collected from 360 children whose age is between 1 to 2 years who live in Hawassa city. The data analysis result showed that only 51% of the children are fully vaccinated; the main reason for vaccination dropout which weighs 57% was found to be disremembering the appointment date. Providing a solution to not only one of the main reasons but also for the one which weighs the most in the city of this study will improve the vaccination coverage. As the main reason is found to be disremembering the vaccination appointment date, this work provides a Short Message Service (SMS) based automatic reminding system. The design part uses a database, OzekiNG network gateway, and global system for mobile communication modem with an active subscriber identity module. In this system, the health extension workers will register the clients’ detailed information including appointment dates during the birth of a baby that will be accessed periodically by the OzekiNG to send the reminder SMS to the mothers one day ahead of the day of vaccination. After the automatic reminding mechanism was developed and implemented, coverage of fully vaccinated children increased from 51–71% and the problem of forgetting appointment dates decreases from 57–14%. The efficiency of the developed system is found to be 85%. From the above-mentioned results and the currently available communication mechanisms, it can be concluded that the reminding system can be simply implemented to improve child vaccination coverage by bridging the gap due to disremembering the vaccination appointment date.
Research on Quality of Family-centered Information Communication Service in Perioperative Period
Authors: Dai Jinghua , Zhang Manhong , Wang Juzi , Zhao Qian , Bian Haiyan , Ren Lingai , Wang Fangfang , Gao Wenhui , Zhang Xu , Ren Xiaoqiang
Published: September 2022

Objective To use the service quality gap model to analyze the information communication service in perioperative period and formulate management measures to improve the experience for surgery patients in perioperative period.
Method 114 families of level 3 and level 4 elective surgical patients in a Grade-A Tertiary Hospital from January to March in 2022 were analyzed by cross-sectional cluster sampling. The assessment scale of the information communication service in perioperative period, which involved 5 dimensions and 22 items in total, was made by referring to the model framework and combining the positioning and characteristics of operating theatre service. The expectation scale was distributed 1 day prior to surgery, and the perception scale was distributed 1 day after operation. The gap between the expected and perceived service quality was analyzed, classified and ranked, the multi-factor analysis method was used to determine the effect of patients’ general state on patients’ perceived service, and the service quality gap model was also used to analyze the survey result to determine the demand attributes.
Result The perception level of family-centered information communication service in perioperative period is (6.23±0.32), the mean of expectation is (6.72±0.30), and the score difference is significant statistically (P＜0.05); the average SQ of 5 dimensions is ranked as follows: responsiveness, assurance, tangibility, reliability, empathy; age, times of medical treatment and self-care ability are all factors that affect nursing service.
Conclusion: The service quality gap model is a method of service quality evaluation from the perspective of patients’ families. The application of the model to the analysis of service subject’s expectations and actual feelings can be used to help managers to find out the root that results in quality problems and look for the proper measures with pertinence that eliminate the gap.
Tenecteplase for Intravenous Thrombolysis of Ischemic Stroke: A Single MRI-based Comprehensive Stroke Center Experience
Authors: Kim Yongwoo , Upadhyaya Parth , Moriarty-Poole Karen , Burton Shannon , Craft Veronica A , Koshlap Karl , Somani Sana , Hsia Amie W
Published: September 2022

Background: Tenecteplase is a tissue plasminogen activator with higher fibrin specificity compared with Alteplase. Accumulating data suggests that intravenous Tenecteplase 0.25mg/kg is non-inferior to Alteplase 0.9mg/kg for acute ischemic stroke. We describe our 10-months experience.
Methods: At our MRI-based, urban comprehensive stroke center, we switched the intravenous thrombolytic agent for acute ischemic stroke to Tenecteplase 0.25mg/kg on March 23, 2021. Until January 31, 2022, 62 stroke patients were treated with Tenecteplase. We compared clinical and safety outcomes of Tenecteplase-treated patients with 94 Alteplase-treated patients.
Results: During the study period, nine (15%) patients with unknown stroke onset were thrombolyzed with MRI screening. Nineteen (35%) patients underwent subsequent thrombectomy. When compared with Alteplase-treated patients, there was no difference with Tenecteplase-treated patients in 90-day functional outcome, death, symptomatic intracranial hemorrhage, or angioedema.
Conclusions: The use of Tenecteplase for stroke thrombolysis was feasible with comparable safety and functional outcomes compared to Alteplase, even when Tenecteplase was administered based on MRI screening to stroke patients with unknown onset.
Expression pattern of FmNAC11 transcription factor in Fraxinus mandshurica and its function in improving cold resistance
Authors: Cao Yang , Song Fei , Liu Zhang , Zhan Yaguang
Published: September 2022

Background: NAC domain proteins contain one of the largest families of plant specific TFs. NAC (Nam, no apical meristem; ataf1/2, Arabidopsis transcription activation factor; CUC2, cup-shaped cotyledon) is an acronym for the names of three genes originally described as containing domains, namely Nam (no apical meristem), ataf1/2 (Arabidopsis transcription activator) and CUC2 (cupular cotyledon) are plant specific transcription factors. As a regulator of gene expression, transcription factors (TF) play an important role in plant development and response to hormone signals. In order to clarify the function of Fraxinus mandshurica fmnac11 gene under biological and abiotic stress,
Results: the cloned fmnac11 gene of Fraxinus mandshurica was 891bp, encoding 296 amino acids. Subcellular localization showed that fmnac11 was located in the nucleus and was indeed a transcription factor with transcriptional activation activity. Fmnac11 can respond to cold, NaCl stress, and IAA, GA, ABA hormone signal induction. The promoter length of the cloned fmnac11 gene was 2340bp. By analyzing cis acting elements, it was found that the promoter of fmnac11 gene responded to biological and abiotic stresses, participated in a variety of biological pathways, and regulated biological processes. Four transgenic lines overexpressing fmnac11 were obtained by Agrobacterium mediated transformation of WT tissue culture seedlings of Benxi tobacco. The transgenic plants grew rapidly after transplantation- Under the condition of low temperature culture at -5 ℃ for 24 hours, the wilting and yellowing degree of transgenic plants is significantly less than that of ordinary tobacco, and the transgenic tobacco overexpressing fmnac11 performs better in membrane system, osmotic system and ROS scavenging system than ordinary tobacco, indicating that fmnac11 gene has the function of improving plant cold resistance.
Conclusion: the gene expression of transgenic tobacco under cold treatment shows that fmnac11 transcription factor has a regulatory relationship with growth related IAA and AUX1 genes, cold resistance related ice, DREB and CBF1, ROS clearance related cat and SOD genes, which promotes the rapid growth, cold resistance and ROS clearance ability of transgenic tobacco.
Optimized construction of marble pieces as a thermal storage materials for performance improvement of hemispherical solar distiller
Authors: Attia Mohammed El Hadi , Kabeel Abd elnaby , Abdelgaied Mohamed , Sathyamurthy Ravishankar
Published: September 2022

The present work aims to obtain the optimized construction of marble pieces that achieves the highest hemispherical solar distiller’s performance. To achieve this idea, four different marble pieces (black marble pieces, green marble pieces, red marble pieces, and white marble pieces) were tested to obtain the optimal construction of the marble that achieves the highest hemispherical solar distiller performance. The marble pieces were placed on a basin of hemispherical distillers which represent absorber materials, as well as the sensible thermal storage materials. This was done by design and constructed three hemispherical distillers, first represent the classical hemispherical distiller (CHD) which represent the reference case, but the marble pieces were placed inside the basin of the second and third distiller. The experimentation tested were conducted on two cases; in the first case we tested two types of marble pieces (black and green marble pieces) by placed them in the second and third distiller (hemispherical distiller with black marble pieces (HSD-BMP) and hemispherical distiller with green marble pieces (HSD-GMP)). In the second case we tested the other two types of marble pieces (red and white marble pieces) by placed them in the second and third distiller (hemispherical distiller with red marble pieces (HSD-RMP) and hemispherical distiller with white marble pieces (HSD-WMP)). The results showed that utilization of red marble pieces (HSD-RMP) represents a good choice which improved the accumulative productivity to 7.75 l/m2 day compared to 4.8 l/m2day that achieved by the CHD with an improvement of 61.46%. The accumulative thermal efficiency of CHD reached 39.25%, while the utilization of red marble pieces (HSD-RMP) improved the accumulative thermal efficiency to 62.98%. Also, the use of red marble pieces reduced the distillate cost by 35.6% compared to the reference distiller.
Ieal Atresia and Total Colonic Hirschsprung Disease in a 36-week Neonate : Case Report
Authors: Atqiaee Khashayar , Hiradfar Mehran , Mashhadi Mahdi Parvizi , Khanghah Ali Samady
Published: September 2022

Intestinal atresia and Hirschsprung disease are two common causes of bowel obstruction in neonates, and simultaneous occurrence is rare.
This report delineates a 36-week newborn with ileal atresia and total colonic Hirschsprung.
A newborn male (gestational week 36; birth weight,2500 gram) was referred to our unit due to failure of meconium Passage during the first 48 hours after birth, abdominal distension, and bilious vomiting.
Physical examination revealed a prominent abdomen, decreased bowel sounds, and an empty rectum in digital rectal examination.
The abdominopelvic radiograph showed dilated intestinal loops. No gas was observed in the rectum.
Intraoperative findings were: Type three Ileal atresia with classic V shape deformity in the mesentery just 10 mm proximal to the ileocecal valve. All parts of the large bowel were unused (microcolon).
H&E examination of colonic biopsies revealed the absence of Ganglion cells in all parts of the large bowel.
Analysis of hyperprogressive disease due to atezolizumab plus bevacizumab treatment in patients with advanced hepatocellular carcinoma
Authors: Yumita Sae , Ogasawara Sadahisa , Nakagawa Miyuki , Maruta Susumu , Okubo Tomomi , Itokawa Norio , Iino Yotaro , Obu Masamichi , Haga Yuki , Seki Atsuyoshi , Kogure Tadayoshi , Ishino Takamasa , Ogawa Keita , Fujiwara Kisako , Iwanaga Terunao , Fujita Naoto , Sakuma Takafumi , Kojima Ryuta , Kanzaki Hiroaki , Koroki Keisuke , Inoue Masanori , Kobayashi Kazufumi , Kiyono Soichiro , Nakamura Masato , Kanogawa Naoya , Saito Tomoko , Kondo Takayuki , Nakagawa Ryo , Nakamoto Shingo , Muroyama Ryosuke , Chiba Tetsuhiro , Itobayashi Ei , Atsukawa Masanori , Koma Yoshihiro , Azemoto Ryosaku , Ito Kenji , Mizumoto Hideaki , Kato Jun , Kato Naoya
Published: September 2022

Background
Hyperprogressive disease (HPD) is a phenomenon with greatly accelerated tumor growth and clinical deterioration rates compared to pre-therapy, in patients treated with immune checkpoint inhibitors (ICI). The aim of this study is to clarify the reality of HPD in patients with advanced hepatocellular carcinoma (HCC) who were treated with atezolizumab plus bevacizumab (Atez/Bev) using tumor dynamics.
Methods
Medical records of consecutive patients with advanced HCC who were treated with Atez/Bev were retrospectively reviewed. HPD was defined as a more than two- or fourfold increase in tumor growth rate (TGR) or tumor growth kinetics rate (TGKR) pre- and post-treatment. Overall survival (OS) and baseline characteristics with or without HPD were analyzed.
Results
A total of 85 patients were included in the analysis. When HPD was defined as a twofold of TGR or TGKR, 8 patients (9.4%, 8/85) had HPD and 11 had PD without HPD. A total of 5 patients (5.9%, 5/85) were diagnosed with HPD and 14 with PD without HPD when HPD was defined as a fourfold of TGR or TGKR. No significant difference was observed in the baseline characteristics and OS between HPD and non-HPD.
Conclusion
The prevalence of HPD in patients with advanced HCC treated with Atez/Bev was lower than those treated with nivolumab monotherapy. The HPD mechanism in ICI combined with antibodies targeting vascular endothelial growth factor (VEGF) remains to be elucidated.
Medication adherence and its impact on glycemic control in type 2 diabetes mellitus patients with comorbidity: A multicenter cross-sectional study in Northwest Ethiopia
Authors: Sendekie Ashenafi Kibret , Netere Adeladlew Kassie , Kasahun Asmamaw Emagn , Belachew Eyayaw Ashete
Published: September 2022

Background: Medication nonadherence in patients with chronic diseases, particularly in type 2 diabetes mellitus (T2DM) with comorbidity has continued to be the cause of treatment failure. The current study assessed medication adherence and its impact on glycemic control in T2DM patients with comorbidity.
Methods: An institutional-based multicenter cross-sectional study was conducted among T2DM patients with comorbidity at the selected hospitals in Northwest Ethiopia. Medication adherence was measured using a structured questionnaire of the General Medication Adherence Scale (GMAS). A logistic regression model was used to identify predictors of the level of medication adherence and glycemic control. P < 0.05 at 95% confidence interval (CI) was statistically significant.
Results: A total of 403 samples were included in the final study. This study showed that more than three-fourths (76.9%) of the participants were under a low level of medication adherence. The source of medication cost coverage [AOR=10.593, 95% CI (2.628–41.835; P = 0.003], monthly income (P < 0.00), self-monitoring of blood glucose (SMBG) practice [AOR=0.266, 95% CI (0.117–0.604); P = 0.002], the number of medications [AOR=0.068, 95% CI (0.004–0.813); P = 0.014] and number of medical conditions [AOR = 0.307, 95% CI (0.026–0.437); P = 0.018] were found to be significant predictors of medication adherence. Significantly, most (74.7%) of the study participants had poor levels of glycemic control. Patients who had a high level of medication adherence [AOR = 0.003, 95% CI (0.000–0.113); P = 0.002] were found less likely to have poor glycemic control compared to patients who were low adherent to their medications.
Conclusion: The current study concluded that medication adherence was low and significantly associated with poor glycemic control. Therefore, management intervention and management of T2DM patients with comorbidity should focus on the improvement of medication adherence and other predictor variables.
Swallowing Disorders and Mortality in Adults with Advanced Cancer Outside the Head and Neck and Upper Gastrointestinal Tract: A Systematic Review
Authors: Silva Danielle Nunes Moura , Vicente Laélia Cristina Caseiro , Glória Vanessa Laís Pontes , Friche Amélia Augusta de Lima
Published: September 2022

Background

Although oncological palliative care is increasingly being offered by multidisciplinary teams, there is still a lack of data about some symptoms handled by these teams, such as dysphagia, in patients with advanced cancer outside swallow regions. This study aimed to estimate the occurrence of dysphagia in prognosis studies of adults with advanced cancer outside the head, neck, and upper gastrointestinal tract, and to determine if there is an association with mortality.

Methods

A systematic review of studies that evaluated dysphagia and mortality was conducted (PROSPERO: CRD42021257172). Data sources: BVS, PubMed, CINAHL, Web of Science, and Scopus. Data between January 1, 2011 and June 30, 2021 were selected for the current study.

Results

Among the 408 articles screened, only 11 were included. Dysphagia demonstrated a variable frequency, and almost half of the studies found a percentage of dysphagia above 60%, appearing most as a symptom that affects health-related quality of life and prove to be a toxicity of treatment. The association between dysphagia and mortality was only evaluated in two articles that studied advanced lung cancer, in which, after controlling for covariates, swallowing disorders were associated with worse survival, with hazard ratios of 1.12 and 1.34.

Conclusions

The occurrence of dysphagia in advanced cancer outside anatomical swallowing regions is common, and there seems to be an association with significantly decreased survival in patients with advanced lung cancer.
Comprehensive Analysis of Differentially Expressed Circular RNAs in Keloid Dermal Tissues
Authors: Liu Yunhan , Zhang Zewei , Huang Xin , Gu Shuchen , Khoong Yimin , Li Zhouxiao , Xia Wenzheng , Zan Tao
Published: September 2022

Background Keloid is a dermal fibroproliferative disease with various etiologies and unclear pathogenesis. Recent studies have revealed that circular RNAs (circRNAs) exerted regulatory functions through a competing endogenous RNA (ceRNA) pathway in keloid progression. However, the expression profiles of circRNAs in keloid dermal tissues (KDTs) remain unknown. This study aimed to identify differentially expressed circRNAs (DECs) and genes (DEGs) in KDTs, as well as to investigate the potential biological functionsof circRNAs based on the circRNA-miRNA-mRNA ceRNA network.ResultsThrough high-throughput RNA sequencing (RNA-seq), we revealed 3467 DEGs (865 up- and 2602 down-regulated) and 330 DECs (162 up- and 168 down-regulated) in KDTs. To reveal the functions of DECs preliminarily, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed for the host genes. Further, the up- and down-regulated DECs-miRNAs-DEGs regulatory networks were constructed, respectively. The functional prediction for the target genes showed that the up-regulated ceRNA network was associated with extracellular matrix and multiple cellular functions. The down-regulated ceRNA network was enriched in cell-cell junction and other biological processes. Cytoscape was used to visualize each network's protein-protein interaction (PPI) network and identify hub genes. By quantitative Real-Time PCR (qRT-PCR), hsa_circ_0060927, hsa_circ_0071410, hsa_circ_0058092, hsa_circ_0002874, hsa_circ_0004682, hsa_circ_0072688, hsa_circ_0006401, and hsa_circ_0055954 were identified significantly up-regulated in KDTs. Within, hsa_circ_0072688, which was up-regulated both in KDTs and keloid dermal fibroblasts (KDFs), and located in the cytoplasm, might be a key circRNA and affect the progression of keloid by impacting extracellular matrix, cell adhesion, and cell apoptosis, etc.ConclusionThis study not only filled a gap in the circRNA library of KDTs but also laid a foundation for probing the biological function of DECs in keloids. Hsa_circ_0072688 was thought to be a key circRNA and more experimental support is needed.
Effect of different dietary protein levels on goats’ blood parameters of Tswana goats reared in extensive production systems
Authors: Tsheole Mpho Sylvia , Mwanza Mulunda
Published: September 2022

In this study, an experiment was conducted to determine the impact of different dietary protein levels on a goat’s blood parameters. Twenty-four female Tswana weaner goats with similar body weights and ages (3 months old and 10.56±1.28 kg) were used for the experiment. Animals were grouped into three treatment groups of eight goats each in a randomised block design according to live weight. Animals were fed protein 23.51g/kg and energy 8.55g/kg DM and then given Lucernead libitum. Blood samples were collected on the first day of the experiment and then weekly until the end of the experiment (365) days. Samples collected were analysed for blood biochemistry a hematologicalcal parameters. Different levels of protein supplementation in goats significantly affected blood glucose, albumin, albuglobulin and urea (P<0.05). It was also noted that hematological parameters were influenced significantly (P<0.05) by the physiological stages of animals. Supplementation of protein influenced blood parameters, which gave an indication of the nutrition and energy status of animals. Incidences of fluctuations in some parameters were observed during this experiment and could have resulted from undetected minor infections, and weather extremities in the study area. The findings revealed that there was no impact on different diet levels of protein supplementation on the health status of animals hence, farmers could be advised to supplement with nutrient density which is cheaper. However, the effects of protein supplementation could also explain the effects on reproduction parameters.
Comparative Transcriptome Sequencing Analysis to Postulate the Scheme of Regulated Leaf Coloration in Perilla frutescens
Authors: Liu Xiaoning , Zhai Yanning , Liu Jingyu , Xue Jingqi , Markovic Tatjana , Wang Shunli , Zhang Xiuxin
Published: September 2022

Perilla as herb, ornamental, oil and edible plant is widely used in East Asia. Until now, the mechanism of regulated leaf coloration is still unclear. In this study, four different kinds of leaf colors were used to measure pigment contents and do transcriptome sequence to decipher the mechanism of leaf coloration. The measurements of chlorophyll, carotenoid, flavonoid, and anthocyanin showed that higher contents of all the above pigments were in full purple leaf ‘M357’, and they may be determined front and back leaf color formation with purple. Meanwhile, the content of anthocyanin was controlled back leaf coloration. The chromatic aberration analysis and correlative analysis between different pigments and L*a*b* values analysis also suggested front and back leaf color change was correlated with the above four pigments. The genes involved in leaf coloration were identified through transcriptome sequence. The expression levels of chlorophyll synthesis and degradation related genes, carotenoid synthesis related genes and anthocyanin synthesis genes showed up-/down-regulated expression in different color leaves and were consistent of these pigments’ accumulation. It was suggested that they were the candidate genes regulated perilla leaf color formation, and genes including F3’H, F3H, F3’,5’H, DFR, and ANS are probably important for regulating both front and back leaf purple formation. Transcription factors involved in anthocyanin accumulation, and regulating leaf coloration were also identified. Finally, the probable scheme of regulated both full green and full purple leaf coloration and back leaf coloration was postulated.
Strategic Leadership Change and Corporate Social Performance and Financial Distress as Moderating Role: Evidence from Emerging Economies
Authors: Hussain Shahid , Rasheed Abdul
Published: September 2022

Exchange in strategic leadership has necessary insinuations in place of corporate social performance and acceptability. Such as, new chief executive officers ensure a robust inducement to join massive investors to shape their acceptance as accurate with and reputation inside the firm. We look at the Salience Theory of Stakeholder to look at a state line circumstance, the financial distress presence, which could create a new chief executive officer's potential to perform this task. We amalgamated the records with the South Asia record to achieve basic statistics up to the firm-level. This stage furnished 9,647 observations for 759 organizations. We discuss the differential impacts among externally recruited chief executive officers (outsiders) and internally promoted chief executive officers (insiders) beneath the financial distress’ situation. We discuss that after organizations revel in financial distress; chief executive officers (outsiders) may rapidly transfer their interest and place in order hobbies of the shareholders on investors than chief executive officers (insiders). Our observation supports the strategic leadership and corporate social performance literature via offering the latest visions mad about how the turnover of corporate management and the context of firms could mutually form innovative decision-making of chief executive officers in the engagement of corporate social performance.
Tobacco cigarettes smoking and e-cigarettes using among university students: a cross-section survey in Guangzhou, China, 2021
Authors: Song Hongjia , Yang Xuemin , Yang Wanchun , Duan Kun , Jiang Xingtao , Huang Guangye , Li Min , Liu Peiqing , Chen Jianwen
Published: September 2022

Background
There is an increase in the use of nicotine products worldwide, and similar trends may be observed in young adults. Cigarettes are consumed most heavily in China. However, there is limited information about Chinese nicotine product users and trends in nicotine product use among university students. Therefore, our objectives were to investigate the using status of nicotine products and smoking behavior among the students from 7 universities in Guangzhou, China.
Methods
Students at 7 different universities in Guangzhou were surveyed online in 2021 through a cross-sectional survey. A total of 10008 students were recruited and after screening, 9361 participants were adopted in our statistics. Descriptive analysis, Chi-square analysis, and multivariate logistic regression analysis were used to explore the smoking status and influencing factors.
Results
A total of 58.3% of participants were male. 29.8% of the participants used nicotine products. The average age of the 9361 university students was 22.4 years (SD = 3.6). Among the users of nicotine products, 16.7% were e-cigarettes only users, 35.0%were tobacco cigarettes only users, and 48.3% were dual users.
Males were more likely to use nicotine products. Medical students, students from prestigious Chinese universities, and students with higher levels of education were less likely to use nicotine products. Similarly, students with unhealthy lifestyles (e.g., drinking alcohol, playing games excessively, staying up late) were more likely to use nicotine products. Emotion can have significant impacts on both tobacco cigarettes and e-cigarettes dual users when choosing nicotine products to use. More than half of dual users said they would choose tobacco cigarettes when they were depressed and e-cigarettes when they were happy.
Conclusion
We identified factors influencing the use of nicotine products among university students in Guangzhou, China. Gender, education level background, specialization, lifestyle habits and emotion all influenced the use of nicotine products among university students in Guangzhou, China. Male, low education level, from non-prestigious Chinese universities or vocational schools, non-medical specialization, and presence of unhealthy lifestyles were susceptibility factors for the use of tobacco cigarettes and e-cigarettes among university students in Guangzhou. Besides, emotions can influence dual users' choice of products.
The dual role of TRIM3 in colorectal cancer dependent on p53 status by retaining p53 in the cytoplasm to decrease its expression in the nuclei
Authors: Han Yang , Lu Su , Song Chenlong , Xuan Yi , Zhang Meng , Cai Hong
Published: September 2022

Colorectal cancer is a very heterogeneous disease caused by the interaction of genetic and environmental factors. P53, a few exceptions, is a frequent mutation and plays a critical role in the adenoma-carcinoma transition during the tumorous pathological process. Our team screened the series of genes’ expression by high-content screening techniques to discover TRIM3 a newly tumor-associated gene in CRC. TRIM3 demonstrated both tumor-suppressive and tumorigenic features dependent on p53 wild or mutant status in cell experiments in our study. TRIM3 could directly interact with the C terminus of p53 (residues 320 to 393), a common segment of wtp53 and mutp53. Moreover, TRIM3 could decrease p53 levels in the nuclei by retaining them in the cytoplasm to exert different neoplastic biological features in a wtp53 or mutp53 dependent pathway. Chemotherapy resistance develops in nearly all patients with advanced CRC and seriously limits the therapeutic efficacies of anticancer drugs. TRIM3 could successfully reverse the chemotherapy resistance of oxaliplatin in mutp53 CRC cells by decreasing mutp53 in the nuclei to downregulate the multidrug resistance gene. Therefore, TRIM3 could be a potential therapeutic strategy to improve the survival of CRC patients with mutp53 by degradation mutp53 in the nuclei.
Selenium alleviates ER calcium depletion-induced endoplasmic reticulum stress dependent apoptosis via PERK/ATF4/CHOP pathway in chicken myocardium after mercuric chloride exposure
Authors: Gao Pei-Chao , Wang An-Qi , Chen Xue-Wei , Cui Han , Li Yue , Fan Rui-Feng
Published: September 2022

Mercury (Hg) is a highly toxic heavy metal with definite cardiotoxic properties. Selenium (Se) is a heart-healthy trace element and has been demonstrated to attenuate heavy metal induced organ toxicity. This study was designed to explore the antagonistic effect of Se on the cardiotoxicity of mercuric chloride (HgCl2) in chicken. Histopathological observations demonstrated that Se attenuated HgCl2-induced myocardial injury, which was further confirmed by the results of serum CK and LDH levels assay and myocardial tissues oxidative stress indexes assessment. The results showed that Se prevented HgCl2-induced cytoplasmic Ca2+ overload and endoplasmic reticulum (ER) Ca2+ depletion mediated by Ca2+-regulatory dysfunction of the ER. Importantly, ER Ca2+ depletion led to unfolded protein response (UPR) and endoplasmic reticulum stress (ERS), resulting in apoptosis of cardiomyocytes via the PERK/ATF4/CHOP pathway. Subsequently, the heat shock proteins expression activated by HgCl2 through these stress responses, which was reversed by Se. Moreover, Se supplementation partially eliminated the effects of HgCl2 on the expression of several ER-settled selenoproteins, including selenoprotein K (SELENOK), SELENOM, SELENON and SELENOS. In conclusion, these results suggested that Se alleviated ER Ca2+ depletion and oxidative stress induced ERS dependent apoptosis via PERK/ATF4/CHOP pathway in chicken myocardium after HgCl2 exposure.
Pathogen Clearance-based Correlates of Immunoprotection Reveal Insightful Features of Vaccine Immunity
Authors: Zhang Jing-Ren , Tian Xianbin , Wang Juanjuan , Chen Haoze , Ding Ming , Jin Qian
Published: September 2022

Vaccination has significantly reduced the incidence of invasive infections caused by several bacterial pathogens, including Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis. However, no vaccines are available for many other invasive pathogens. A major hurdle in vaccine development is the lack of functional markers to quantify vaccine immunity in eliminating pathogens in the process of infection. Based on our recent discovery of the liver as the major organ of vaccine-induced clearance of blood-borne virulent bacteria, we here describe a new vaccine evaluation system that quantitatively characterize important properties of effective vaccines in shuffling virulent bacteria from the blood circulation to the liver resident macrophage Kupffer cells (KCs) and sinusoidal endothelial cells (LSECs) in animal models. This system consists of three related correlates or assays: pathogen clearance from the bloodstream, pathogen trapping in the liver, and pathogen capture by KCs/LSECs. The readouts of these correlates were consistently associated with the serotype-specific immunoprotection levels of the 13-valent pneumococcal polysaccharide conjugate vaccine (PCV13) against lethal infections of S. pneumoniae, a major invasive pathogen of community-acquired infections in humans. Furthermore, these assays were able to identify a set of functional differences between two licensed PCV13 brands. Finally, the reliability and sensitivity of these correlates in reflecting vaccine efficacy were verified with whole cell vaccines of Klebsiella pneumoniae and Escherichia coli, two major pathogens in hospital-acquired invasive infections. This system may be used as cost effective readouts to evaluate the immunoprotective potential of vaccine candidates in the preclinical phase by filling the current technical gap in vaccine evaluation between the conventional in vitro approaches (e.g., antibody production and pathogen neutralization/opsonophagocytosis) and survival of immunized animals.
Comparison of results after 9 years of stress urinary incontinence treatment with transobturator tape and single incision sling.
Authors: Sonia De Miguel Manso , Elena García García , María Cuaresma González , Marta Ibañez Nieto , Julio Gobernado Tejedor , Marta Perez Febles
Published: September 2022

INTRODUCTION AND HYPOTHESIS
Surgical treatment of stress urinary incontinence (SUI) is performed using a tension-free suburethral band, and the most recent is the single-incision sling (SIS) developed to reduce surgical time and minimize the complications associated with retropubic and transobturator bands.
The objective of this study is to compare the SIS bands with the transobturator (TO) bands, in terms of efficacy (objective and subjective continence) and long-term post-surgical complications
METHODS
Prospective observational study, with a 9-year follow-up (2012-20121) at the University Clinical Hospital of Valladolid (Spain), in women who underwent surgery for SUI using suburethral bands, TO or SIS.
RESULTS
271 patients were included, 133 TO and 138 SIS.
The TO group was older and had a higher frequency of hypertension and previous gynecological surgery, including an anti-incontinence technique. SIS patients performed physical activity more frequently and associated a higher percentage of psychiatric pathology.
Surgery time was lower with SIS and TO was significantly associated with POP corrective surgery.
There are no significant differences in immediate (<7 days), intermediate (≥7-30 days) or late (≥1 month) complications.
No significant differences were found in relation to objective or subjective healing using the satisfaction scale, the ICIQ-SF questionnaire, and the PGI-1.
CONCLUSIONS
Although the evidence currently does not place SIS as the gold standard treatment for SUI, in our study we did not observe differences between the two procedures (SIS and TO) during the 9-year follow-up, neither in objective nor subjective cure.