bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced Electrochemical Performance of LiNi0.5Mn1.5O4 Composite Cathodes for Lithium-Ion Batteries by Selective Doping of K+/Cl− and K+/F−
Authors: Wei Aijia , Mu Jinping , He Rui , Bai Xue , Li Xiaohui , Zhang Lihui , Wang Yanji , Liu Zhenfa , Wang Suning
Published: September 2021

K+/Cl− and K+/F− co-doped LiNi0.5Mn1.5O4 (LNMO) materials were successfully synthesized via a solid-state method. Structural characterization revealed that both K+/Cl− and K+/F− co-doping reduced the LixNi1−xO impurities and enlarged the lattice parameters compared to those of pure LNMO. Besides this, the K+/F− co-doping decreased the Mn3+ ion content, which could inhibit the Jahn–Teller distortion and was beneficial to the cycling performance. Furthermore, both the K+/Cl− and the K+/F− co-doping reduced the particle size and made the particles more uniform. The K+/Cl− co-doped particles possessed a similar octahedral structure to that of pure LNMO. In contrast, as the K+/F− co-doping amount increased, the crystal structure became a truncated octahedral shape. The Li+ diffusion coefficient calculated from the CV tests showed that both K+/Cl− and K+/F− co-doping facilitated Li+ diffusion in the LNMO. The impedance tests showed that the charge transfer resistances were reduced by the co-doping. These results indicated that both the K+/Cl− and the K+/F− co-doping stabilized the crystal structures, facilitated Li+ diffusion, modified the particle morphologies, and increased the electrochemical kinetics. Benefiting from the unique advantages of the co-doping, the K+/Cl− and K+/F− co-doped samples exhibited improved rate and cycling performances. The K+/Cl− co-doped Li0.97K0.03Ni0.5Mn1.5O3.97Cl0.03 (LNMO-KCl0.03) exhibited the best rate capability with discharge capacities of 116.1, 109.3, and 93.9 mAh g−1 at high C-rates of 5C, 7C, and 10C, respectively. Moreover, the K+/F− co-doped Li0.98K0.02Ni0.5Mn1.5O3.98F0.02 (LNMO-KF0.02) delivered excellent cycling stability, maintaining 85.8% of its initial discharge capacity after circulation for 500 cycles at 5C. Therefore, the K+/Cl− or K+/F− co-doping strategy proposed herein will play a significant role in the further construction of other high-voltage cathodes for high-energy LIBs.
Porcine Circovirus (PCV) Genotype 2d-Based Virus-like Particles (VLPs) Induced Broad Cross-Neutralizing Antibodies against Diverse Genotypes and Provided Protection in Dual-Challenge Infection of a PCV2d Virus and a Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
Authors: Kang Seok-Jin , Bae Sung-Min , Lee Hye-Jeong , Jeong Young-Ju , Lee Min-A , You Su-Hwa , Lee Hyang-Sim , Hyun Bang-Hun , Lee Nakhyung , Cha Sang-Ho
Published: September 2021

As PCV2d infection has been continuously reported in swine farms in which pigs were vaccinated with PCV2a- or 2d-based vaccines, we attempted to develop a novel vaccine using a PCV2d-based capsid to enhance its protective efficacy. In this study, recombinant virus-like particles (VLPs) of rPCV2a, rPCV2b and rPCV2d were synthesized from the capsid proteins of PCV2a, PCV2b and PCV2d field isolates, respectively. A cross-neutralization assay between the VLPs induced antisera and the field isolates demonstrated the broad cross-neutralizing activities of the rPCV2d-induced antisera. Then, the protective efficacy of rPCV2d as a vaccine candidate was investigated in commercial pigs by rPCV2d vaccination and a single- or dual-challenge infection using a PCV2d strain and a type 1 PRRSV strain. High levels of anti-PCV2d IgG and neutralizing antibodies were induced 3 weeks after vaccination. After the challenge infection, the average ADWG values of the vaccinated group were higher than those of the unvaccinated group. None or a significantly low amount of (p < 0.05) reduced PCV2 genomic DNA was found in the blood, saliva and tissues of the vaccinated pigs, when compared to the unvaccinated group. Moreover, macroscopic and microscopic lesions in the tissues were significantly (p < 0.05) reduced in the vaccinated groups. This study therefore suggests that rPCV2d may be highly useful for the control of diverse field genotypes.
Amblyomma aureolatum Genetic Diversity and Population Dynamics Are Not Related to Spotted Fever Epidemiological Scenarios in Brazil
Authors: Bitencourth Karla , Amorim Marinete , Oliveira Stefan , Gazêta Gilberto
Published: September 2021

Regional differences in tick-borne disease epidemiology may be related to biological variations between vector populations. Amblyomma aureolatum (Ixodida: Ixodidae), a neotropical tick, is known from several regions in Brazil. However, only in the metropolitan area of São Paulo (SP) state are there studies that establish its role as a vector of a pathogenic rickettsia (Rickettsia rickettsii). The aim of the study was to analyze the genetic diversity, population dynamics, and rickettsia infection in A. aureolatum populations from different spotted fever scenarios in Brazil. Samples were subjected to DNA extraction, amplification and sequencing of 12S rDNA, cytochrome oxidase subunit II and D-loop mitochondrial markers for tick population analyses, and gltA, htrA, ompA, and ompB genes for rickettsia researches. Of the 7–17 tick haplotypes identified, 5–13 were exclusive to each population and 2–12 for each epidemiological scenario, as well as three haplotypes shared by all populations. Amblyomma aureolatum populations are expanding, and do not appear to be genetically structured vis-a-vis the different epidemiological scenarios studied. Rickettsia bellii (in SP) and Rickettsia felis (in Santa Catarina) were identified as infecting A. aureolatum. No relationship between tick haplotypes and rickettsia types were observed.
Feline Coronavirus Antivirals: A Review
Authors: Delaplace Manon , Huet Hélène , Gambino Adèle , Le Poder Sophie
Published: September 2021

Feline coronaviruses (FCoV) are common viral pathogens of cats. They usually induce asymptomatic infections but some FCoV strains, named Feline Infectious Peritonitis Viruses (FIPV) lead to a systematic fatal disease, the feline infectious peritonitis (FIP). While no treatments are approved as of yet, numerous studies have been explored with the hope to develop therapeutic compounds. In recent years, two novel molecules (GS-441524 and GC376) have raised hopes given the encouraging results, but some concerns about the use of these molecules persist, such as the fear of the emergence of viral escape mutants or the difficult tissue distribution of these antivirals in certain affected organs. This review will summarize current findings and leads in the development of antiviral therapy against FCoV both in vitro and in vivo, with the description of their mechanisms of action when known. It highlights the molecules, which could have a broader effect on different coronaviruses. In the context of the SARS-CoV-2 pandemic, the development of antivirals is an urgent need and FIP could be a valuable model to help this research area.
Proton Quantum Tunneling: Influence and Relevance to Acidosis-Induced Cardiac Arrhythmias/Cardiac Arrest
Authors: Ababneh Omar , Qaswal Abdallah Barjas , Alelaumi Ahmad , Khreesha Lubna , Almomani Mujahed , Khrais Majdi , Khrais Oweiss , Suleihat Ahmad , Mutleq Shahed , Al-olaimat Yazan , Nawafleh Sager
Published: September 2021

Acidosis and its associated pathologies predispose patients to develop cardiac arrhythmias and even cardiac arrest. These arrhythmias are assumed to be the result of membrane depolarization, however, the exact mechanism of depolarization during acidosis is not well defined. In our study, the model of quantum tunneling of protons is used to explain the membrane depolarization that occurs during acidosis. It is found that protons can tunnel through closed activation and inactivation gates of voltage-gated sodium channels Nav1.5 that are present in the membrane of cardiac cells. The quantum tunneling of protons results in quantum conductance, which is evaluated to assess its effect on membrane potential. The quantum conductance of extracellular protons is higher than that of intracellular protons. This predicts an inward quantum current of protons through the closed sodium channels. Additionally, the values of quantum conductance are influential and can depolarize the membrane potential according to the quantum version of the GHK equation. The quantum mechanism of depolarization is distinct from other mechanisms because the quantum model suggests that protons can directly depolarize the membrane potential, and not only through indirect effects as proposed by other mechanisms in the literature. Understanding the pathophysiology of arrhythmias mediated by depolarization during acidosis is crucial to treat and control them and to improve the overall clinical outcomes of patients.
Pharmacogenetics in Pharmaceutical Care—Piloting an Application-Oriented Blended Learning Concept
Authors: Stäuble Céline K. , Jeiziner Chiara , Hersberger Kurt E. , Meyer zu Schwabedissen Henriette E. , Lampert Markus L.
Published: September 2021

To enable application-oriented training of Swiss pharmacists on pharmacogenetic (PGx) testing, an advanced, digital training program was conceptualized based on the Miller’s Pyramid framework, using a blended learning approach. The PGx advanced training program included an asynchronous self-study online module, synchronous virtual classroom sessions with lectures and workshops, and a follow-up case study for in-depth applied learning including the analysis of the participants’ PGx profile. The evaluation of the training program consisted of (a) an assessment of the participants’ development of knowledge, competencies and attitudes towards PGx testing in the pharmacy setting; (b) a satisfaction survey including; (c) questions about their future plans for implementing a PGx service. Twenty-one pharmacists participated in this pilot program. The evaluation showed: (a) a significant improvement of their PGx knowledge (mean score in the knowledge test 75.3% before to 90.3% after training completion) and a significant increase of their self-perceived competencies in applying PGx counselling; (b) a high level of satisfaction with the training program content and the format (at least 79% expressed high/very high agreement with the statements in the questionnaire); (c) a mixed view on whether participants will implement PGx testing as a pharmacy service (indecisive 8; agreed/completely agreed to implement 7/1; disagreed 3 (n = 19)). We consider ongoing education as an important driver for the implementation of PGx in pharmacy practice.
Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections
Authors: Niculescu Adelina-Gabriela , Grumezescu Alexandru Mihai
Published: September 2021

Oral health is an essential element in maintaining general well-being. By preserving the complex equilibrium within the oral microbial community, commensal microorganisms can protect against extrinsic pathogenic threats. However, when an imbalance occurs, the organism is susceptible to a broad range of infections. Synthetic drugs can be administered to help the body fight against the fungal, bacterial, or viral burden. Nonetheless, they may produce undesirable consequences such as toxicity, adverse effects, and drug resistance. In this respect, research has focused on finding safer and more efficient alternatives. Particularly, increasing attention has been drawn towards developing novel formulations based on natural compounds. This paper reviews the plant-based, algae-based, and beehive products investigated for their antimicrobial properties, aiming to thoroughly present the state of the art on oral infection prevention in the ear, nose, and throat (ENT) field.
Drag Reduction Using Additives in Smooth Circular Pipes Based on Experimental Approach
Authors: Utomo Allessandro , Riadi Achmad , Gunawan  , Yanuar
Published: September 2021

Reduction of fluid resistance using the rheological characteristics of a polymer-surfactant solvent is research that contains many aspects, such as the theory of the drag reduction process, historical journey, and ongoing current research development. Many studies have been conducted, but it is challenging to know all existing and new research threads. The present investigation was conducted using literature studies regarding drag reducing agents. This research will also discuss the characteristics of flowing fluids and their effects on the velocity profile with friction factor of flowing fluids in smooth circular straight pipe geometries based on experimental, theoretical approaches. It concludes with aspects of research conducted around reducing drag using drag reducing agents, ideas about innovations, structuring overlook in testing, and modification of the fluid flow state.
Microbiome Associated with Slovak Traditional Ewe’s Milk Lump Cheese
Authors: Lauková Andrea , Micenková Lenka , Pogány Simonová Monika , Focková Valentína , Ščerbová Jana , Tomáška Martin , Dvorožňáková Emília , Kološta Miroslav
Published: September 2021

Worldwide consumers increasingly demand traditional/local products, to which those made from ewe’s milk belong. In Slovakia, dairy products made from ewe’s milk have a long tradition. A total of seventeen farmhouse fresh ewe’s milk lump cheeses from various local farm producers in central Slovakia were sampled at farms and then analyzed. Based on the sequencing data analysis, the phylum Firmicutes dominated (60.92%) in ewe’s lump cheeses, followed with the phylum Proteobacteria (38.23%), Actinobacteria (0.38%) and Bacteroidetes (0.35%). The phylum Firmicutes was represented by six genera, among which the highest amount possessed the genus Streptococcus (41.13%) followed with the genus Lactococcus (8.54%), Fructobacillus (3.91%), Enterococcus (3.18%), Staphylococcus (1.80%) and the genus Brochotrix (0.08%). The phylum Proteobacteria in ewe’s lump cheeses involved eight Gram-negative genera: Pseudomonas, Acinetobacter, Enterobacter, Ewingella, Escherichia-Shigella, Pantoea and Moraxella. The phylum Bacteroidetes involved three genera: Bacteroides, Sphingobacterium and Chrysobacterium. Results presented are original; the microbiome of Slovak ewe’s milk lump cheese has been not analyzed at those taxonomic levels up to now.
Heparanase (HPSE) Associates with the Tumor Immune Microenvironment in Colorectal Cancer
Authors: Liu Mengling , Liu Qing , Yuan Yitao , Li Suyao , Dong Yu , Liang Li , Zou Zhiguo , Liu Tianshu
Published: September 2021

There is an unmet clinical need to identify potential predictive biomarkers for immunotherapy efficacy in mismatch repair proficient (pMMR) metastatic colorectal cancer (mCRC). Heparanase (HPSE) is a multifunctional molecule mediating tumor–host crosstalk. However, the function of HPSE in the tumor immune microenvironment of CRC remains unclear. Data of CRC patients from public datasets (TCGA and GSE39582) and Zhongshan Hospital (ZS cohort) were collected to perform integrative bioinformatic analyses. In total, 1036 samples from TCGA (N = 457), GSE39582 (N = 510) and ZS cohort (N = 69) were included. Samples of deficient MMR (dMMR) and consensus molecular subtypes 1 (CMS1) showed significantly higher HPSE expression. The expression of HPSE also exhibited a significantly positive association with PD-L1 expression, tumor mutation burden and the infiltration of macrophages. Immune pathways were remarkably enriched in the HPSE high-expression group, which also showed higher expressions of chemokines and immune checkpoint genes. Survival analysis suggested that high HPSE expression tended to be associated with shorter overall survival in patients with pMMR mCRC. HPSE might contribute to the immune-activated tumor microenvironment with high levels of immune checkpoint molecules, suggesting that pMMR mCRC with high HPSE expression might respond to immune checkpoint inhibitors.
Generating Sacred Space beyond Architecture: Stacked Stone Pagodas in Sixth-Century Northern China
Authors: Zhao Jinchao
Published: September 2021

A large number of stone blocks, stacked up in diminishing size to form pagodas, was discovered in northern China, primarily eastern Gansu and southeastern Shanxi. Their stylistic traits and inscriptions indicate the popularity of the practice of making stacked pagodas in the Northern dynasties (circa the fifth and sixth centuries CE). They display a variety of Buddhist imagery on surface, which is in contrast with the simplification of the structural elements. This contrast raises questions about how stone pagodas of the time were understood and how they related to contemporaneous pagoda buildings. This essay examines these stacked pagodas against the broader historical and artistic milieu, especially the practice of dedicating Buddhist stone implements, explores the way the stacked pagodas were made, displayed, and venerated, and discusses their religious significance generated beyond their structural resemblance to real buildings.
Evaluation of a Statistical Approach for Extracting Shallow Water Bathymetry Signals from ICESat-2 ATL03 Photon Data
Authors: Ranndal Heidi , Sigaard Christiansen Philip , Kliving Pernille , Baltazar Andersen Ole , Nielsen Karina
Published: September 2021

In this study we present and validate a simple empirical method to obtain bathymetry profiles using the geolocated photon data from the Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) mission, which was launched by NASA in September 2018. The satellite carries the Advanced Topographic Laser Altimeter System (ATLAS), which is a lidar that can detect single photons and calculate their bounce point positions. ATLAS uses a green laser, causing some of the photons to penetrate the air–water interface. Under the right conditions and in shallow waters (<40 m), these photons are reflected back to ATLAS after interaction with the ocean bottom. Using ICESat-2 data from four different overflights above the Heron Reef, Australia, a comparison with SDB data showed a median absolute deviation of approximately 18 cm and Root Mean Square Errors (RMSEs) down to 28 cm. Crossovers between two different overflights above the Heron Reef showed a median absolute difference of 13 cm. For an area north-west of Sisimiut, Greenland, the comparison was done with multibeam echo sounding data, with RMSEs down to between 35 cm, and correspondingly showed median absolute deviations between 33 and 49 cm. The proposed method works well under good conditions with clear waters such as in the Great Barrier Reef; however, for more difficult areas a more advanced machine learning technique should be investigated in order to find an automated method that can distinguish between bathymetry and other signals and noise.
Dried Blood Spot in Toxicology: Current Knowledge
Authors: Niemiec Agnieszka
Published: September 2021

Dried Blood Spot (DBS) is becoming very popular in various medical fields, especially in toxicology. Nowadays it is commonly used in newborn screening for inherited or congenital diseases. This paperwork is based on a review of available literature. DBS is simple and rapid, it does not require trained medical staff to collect the samples. Specimens can be easily and safely transported to the laboratory. DBS provides an opportunity for roadside testing and rather quick results. Venous blood spot, collected from a finger or a heel, is put on the special paper card, which can result in a different distribution of blood and concentration of detecting substances. Marking multiple substances from one spot is extremely challenging, but due to further advancements in this area, it is only a matter of time until it becomes possible and all the disadvantages vanish. DBS is certain to develop and become even more worldwide used.
DXN: Dynamic AI-Based Analysis and Optimisation of IoT Networks’ Connectivity and Sensor Nodes’ Performance
Authors: Lami Ihsan , Abdulkhudhur Alnoman
Published: September 2021

Most IoT networks implement one-way messages from the sensor nodes to the “application host server” via a gateway. Messages from any sensor node in the network are sent when its sensor is triggered or at regular intervals as dictated by the application, such as a Smart-City deployment of LoRaWAN traps/sensors for rat detection. However, these traps can, due to the nature of this application, be moved out of signal range from their original location, or obstructed by objects, resulting in under 69% of the messages reaching the gateway. Therefore, applications of this type would benefit from control messages from the “application host server” back to the sensor nodes for enhancing their performance/connectivity. This paper has implemented a cloud-based AI engine, as part of the “application host server”, that dynamically analyses all received messages from the sensor nodes and exchanges data/enhancement back and forth with them, when necessary. Hundreds of sensor nodes in various blocked/obstructed IoT network connectivity scenarios are used to test our DXN solution. We achieved 100% reporting success if access to any blocked sensor node was possible via a neighbouring node. DXN is based on DNN and Time Series models.
Mitigation of Eutrophication in a Shallow Lake: The Influences of Submerged Macrophytes on Phosphorus and Bacterial Community Structure in Sediments
Authors: Wang Juanjuan , Zhang Siwen , Que Tianyang , Kaksonen Anna H. , Qian Xiaoqing , Zhuang Xuliang , Bohu Tsing
Published: September 2021

Remediating water eutrophication is critical for maintaining healthy and sustainable development of lakes. The aim of this study was to explore the seasonal variation in phosphorus (P) speciation and bacterial community structure in sediments of Qin Lake (Taizhou, Jiangsu Province, China) associated with the growth of submerged macrophyte Vallisneria natans. The differences in sediment bacterial diversity and community structure between V. natans growing and control areas were analyzed over a period of one year. The results showed that V. natans growth reduced the total P and organic matter contents of the sediments and increased the bioavailable iron (Fe) and Fe-bound P contents. The α-diversity of sediment bacteria was significantly higher in the presence of V. natans than in the controls during the vigorous plant growth stage. In the presence of V. natans, there was a higher relative abundance of Proteobacteria and lower relative abundances of Chloroflexi and Acidobacteria. The Fe(II) content in the sediment had a larger influence on the spatial distribution of bacterial communities than sediment Fe-bound P, organic matter, and Fe(II) contents. V. natans growth could reshape sediment bacterial community structure in the shallow lake, which, in turn, enhanced P immobilization in the sediments and thereby improved the water quality.
Urban Sustainability Performance Measurement of a Small Brazilian City
Authors: Caldatto Fernanda Caroline , Bortoluzzi Sandro César , Pinheiro de Lima Edson , Gouvea da Costa Sergio E.
Published: September 2021

The population increase in cities implies the need to balance environmental, social, and economic demands in such a way that growth is guided by sustainable development. This research aimed to build a model for evaluating the performance of urban sustainability in a small Brazilian city. To structure the model, the multicriteria decision support methodology-constructivist (MCDA-C) was adopted, which aims to identify the objectives and criteria of a context based on the actors’ values. The measurement model resulted in 66 criteria, which were measured by considering the reference levels (Good and Neutral). The results of the analysis through the model showed that the city’s urban sustainability performance was good in 45 criteria, excellent in 20, and compromising in 1. Thus, there is a theoretical contribution by presenting a multi-criteria performance assessment methodology focused on the sustainability of small towns and practice by helping to formulate and evaluate public policies. In addition, when confronting the criteria of the model built with the objectives of the Sustainable Development Goals (SDGs), it was identified that, although they are partially aligned, the improvement of performance in local sustainability has positive effects on achieving global goals.
The Impacts of Temporary and Permanent Public Health Policies on HRQOL in a Small Open Economy
Authors: Nakamoto Yasuhiro , Kawagishi Taketo
Published: September 2021

Considering that people can invest in their health-related quality of life (HRQOL), we investigate the effects of public health policies (i.e., a health investment subsidy policy and the direct distribution of health-related goods) on HRQOL in a small open economy. We find that when the government makes public investment in HRQOL temporarily, HRQOL deteriorates or does not improve at least. On the contrary, when public investment is enforced permanently, it improves in the long run.
The Relationship between Contact-Free Services, Social and Personal Norms, and Customers’ Behavior for the Sustainable Management of the Restaurant Industry
Authors: Jang Ha-Won , Lee Soo-Bum
Published: September 2021

People worldwide are experiencing increasingly complex social issues, and ways of life are changing. This study analyzes the relationship between contact-free service value, personal and social norms, and customers’ behavioral intentions for sustainable restaurant businesses, demonstrating a direct association of the value and extended norm theory. Structural equation model analysis was performed to verify causality between variables; multi-group analysis was performed to confirm the moderating effects of menu price using AMOS; and frequency analysis, descriptive statistical analysis, and reliability analysis were performed using SPSS. The data were collected from Koreans aged 18 years and above (310 responses). The results revealed that contact-free service value positively affects personal norms, and personal norms positively affect behavioral intentions. In addition, social norms positively affect personal norms and behavioral intentions. In particular, it was found that social norms greatly influence personal norms. Finally, the menu price moderated the relationship between social and personal norms. These results present a variety of academic and practical implications, and this is especially meaningful for analyzing the association between contact-free service value and norm theory in the food service industry.
Dielectric Elastomer Generator for Electromechanical Energy Conversion: A Mini Review
Authors: Di Kui , Bao Kunwei , Chen Haojie , Xie Xinjun , Tan Jianbo , Shao Yixing , Li Yongxiang , Xia Wenjun , Xu Zisheng , E Shiju
Published: September 2021

The dielectric elastomer generator (DEG) has attracted attention in converting mechanical energy into electrical energy, due to its high energy density, fast response, and light weight, which together make DEG a promising technology for electromechanical conversion. In this article, recent research papers on DEG are reviewed. First, we present the working principles, parameters, materials, and deformation modes of DEG. Then, we introduce DEG prototypes in the field of collecting mechanical energy, including small-scale applications for wind energy and human motion energy, and large-scale applications for wave energy. At the end of the review, we discuss the challenges and perspectives of DEG. We believe that DEG will play an important role in mechanical energy harvesting in the future.
South Baltic Oil Spill Response Project (SBOIL)—Development and Implementation of Models of Drift and Fall Trajectories of Biogenic Oil Binders
Authors: Saathoff Fokke , Siewert Marcus , Przywarty Marcin , Bilewski Mateusz , Muczyński Bartosz , Perkovic Marko , Gucma Lucjan
Published: September 2021

This paper presents the methodology, assumptions, and functionalities of an application developed during the realization of the project “South Baltic Oil Spill Response through Clean-up with Biogenic Oil Binders” (SBOIL). The SBOIL project is a continuation of the BioBind project, the primary goal of which was to develop and deploy an oil recovery system designed for use in coastal waters and adverse weather conditions. The goal of the SBOIL project was to use this new technology to improve the current response capabilities for cross-border oil spills. The developed application allows for the determination of the position of an aircraft at the time of dropping the oil binders, the determination of the oil binders’ position after falling in terms of a specific aircraft’s position, the determination of the position of oil binders after a certain time in order to plan the action of recovering it from the water surface, and the determination of the time when the binders will be in their assumed position.
Exploring Factors That Influence Taekwondo Student Athletes’ Intentions to Pursue Careers Contributing to the Sustainability of the Korean Taekwondo Industry Using the Theory of Planned Behavior
Authors: Seonwoo Yoo-Yeong , Jeong Yun-Duk
Published: September 2021

Due to recently declining fertility rates and the social climate of job preferences in professional occupations in South Korea, the number of teenagers practicing elite Taekwondo has decreased, and Korean Taekwondo is in crisis. In this regard, it is essential for Taekwondo coaches to create a favorable environment preventing student athletes from abandoning careers in Taekwondo and for physical education researchers to explore factors directly or indirectly influencing the intentions to pursue such careers. Thus, the purpose of this study was to examine the structural relationships among mentoring, attitudes, subjective norms, perceived behavioral control, and career pursuit intentions by applying the theory of planned behavior, as well as investigating the moderating influence of Taekwondo identification on these relationships. We collected data from athletes with more than a year of elite Taekwondo experience attending one of 15 high schools in South Korea. We asked a total of 270 athletes to participate in the survey. Of these, 250 completed the survey. We eliminated data for 15 athletes due to repetitive response patterns; thus, we analyzed 235 usable responses. We assessed the measurement scale’s validity and reliability with confirmatory factor analysis, Cronbach’s alpha coefficients, and correlational analysis. Structural equation modeling evaluated the effects of four factors—mentoring, attitudes, subjective norms, and perceived behavioral control—on career pursuit intentions. Additionally, we performed a hierarchical regression analysis to confirm the moderating effect of Taekwondo identification. The results revealed positive impacts of (a) mentoring on attitudes (0.760, p < 0.001), (b) attitudes on career pursuit intentions (0.681, p < 0.001), (c) subjective norms on career pursuit intentions (0.141, p < 0.01), and (d) perceived behavioral control on career pursuit intentions (0.138, p < 0.05). However, Taekwondo identification did not moderate the relationships among the research variables.
Analyzing the Relationship between Animal Diversity and the Remote Sensing Vegetation Parameters: The Case of Xinjiang, China
Authors: Wu Jinhui , Li Haoxin , Wan Huawei , Wang Yongcai , Sun Chenxi , Zhou Hongmin
Published: September 2021

An explicit analysis of the impact for the richness of species of the vegetation phenological characteristics calculated from various remote sensing data is critical and essential for biodiversity conversion and restoration. This study collected long-term the Normalized Difference Vegetation Index (NDVI), the Leaf Area Index (LAI), the Fraction of Absorbed Photosynthetically Active Radiation (FAPAR), and the Fractional Vegetation Cover (FVC), and calculated the six vegetation phenological characteristic parameters: the mean of the growing season, the mean of the mature season, the mean of the withered season, the annual difference value, the annual cumulative value, and the annual standard deviation in the Xinjiang Uygur Autonomous Region. The relationships between the vegetation phenological characteristics and the species richness of birds and mammals were analyzed in spatial distribution. The main findings include: (1) The correlation between bird diversity and vegetation factors is greater than that of mammals. (2) For remote sensing data, FAPAR is the most important vegetation parameter for both birds and mammals. (3) For vegetation phenological characteristics, the annual cumulative value of the LAI is the most crucial vegetation phenological parameter for influencing bird diversity distribution, and the annual difference value of the NDVI is the most significant driving factor for mammal diversity distribution.
Inter-Organizational Trust on Financial Performance: Proposing Innovation as a Mediating Variable to Sustain in a Disruptive Era
Authors: Oláh Judit , Hidayat Yusmar Ardhi , Dacko-Pikiewicz Zdzisława , Hasan Morshadul , Popp József
Published: September 2021

Hungarian Information and Communication Technology (ICT) companies have an essential role to play in a disruptive era. ICT firms should collaborate and innovate to obtain profit. The elusive correlation between trust in business partners and financial performance inspired this study, which proposed innovation as a mediating variable. The research had two objectives: to investigate the effect of inter-organizational trust on financial performance and innovation and to observe the role of innovation in improving financial performance within different categories of ICT companies. The population included active Hungarian ICT firms. The analysis used 100 samples, comprising micro-, small-, and medium-sized ICT corporations. Those samples were selected by random cluster sampling. This research used Partial Least Square Structural Equation Modelling. This study supported the idea that inter-organizational trust improved innovation, and that innovation enhanced financial performance. As an expected finding, innovation could mediate a positive direction between inter-organizational trust and financial performance.
Requalification of RC Frame Apartment Buildings: Comparison of Seismic Retrofit Solutions Based on a Multi-Criteria Approach
Authors: Santarsiero Giuseppe , Masi Angelo , Manfredi Vincenzo , Ventura Giuseppe
Published: September 2021

Increasing environmental concerns are leading to measures and incentives aimed at reducing the energy consumption of buildings, which must be accompanied by substantial mitigation of seismic and structural risk. As for technical issues, it is important to select effective solutions specifically for medium-size RC apartment buildings (e.g., 3–6 storeys), which is where a large share of the Italian population lives today. To this end, it is important to compare, among other factors, the direct and indirect costs related to alternative techniques, thus allowing stakeholders (mainly private) and designers to select the most suitable solution for each case at hand and, finally, to speed up the design process. In this paper, different seismic strengthening techniques are designed and applied to a case study RC frame building that is representative of the EU building stock. An in-depth comparison is made with the aim of showing the advantages and disadvantages of different choices, mainly based on required costs and possible disruptions, keeping the targeted structural performance equal. Specifically, the possibility of disruption is a key point in hastening or, more frequently, hindering the implementation of the decision. In fact, people’s hesitation to leave their home, as well as the difficulty and high costs involved in finding temporary apartments if many people are involved, generally prevent such interventions from taking place. For this reason, some state-of-the-art techniques—that have minimum impact on non-structural elements, that can be applied only on the outside, and that can still provide an effective seismic retrofit—are examined and critically compared in the paper through a multi-criteria decision-making method.
Identifying Health Care Environment Contradictions in Terms of Infection Control during a Pandemic with a Focus on Health Workers’ Experience
Authors: Lesan Maryam , Khozaei Fatemeh , Kim Mi Jeong , Shahidi Nejad Marziyeh
Published: September 2021

During the past year, health care environments have struggled to cope with the various impacts of COVID-19 around the world. Health care facilities need to help strengthen resistance to pathogen threats and provide care for patients and health workers in the safest possible way. Architectural design strategies can play a significant role in infection prevention and control. The current study aims to examine the experiences of health workers with hospital spaces during the COVID-19 pandemic. Identifying the difficulties they face, the present study attempts to shed light on the role of the health care layout configuration in combating pandemics. The authors conducted observations at four hospitals and a series of online semi-structured interviews with 162 health care staff from March to May 2020. The study indicated that space configuration and the hospitalization of patients, layout and circulation of the environment, operation services such as indoor environment conditions, maintenance of health care system, and organizational support for health care staff were the most critical factors affecting infection control in health care environments. The initial zoning and separation of patients were the most effective methods of controlling infection. Hospitals with clustered plan layouts were found to be the most effective buildings for the zoning of COVID-19 patients during the pandemic and for infection control.
Compression Neuropathies of the Upper Extremity: A Review
Authors: Boyd Carter J. , Singh Nikhi P. , Robin Joseph X. , Sharma Sheel
Published: September 2021

Compressive neuropathies of the forearm are common and involve structures innervated by the median, ulnar, and radial nerves. A thorough patient history, occupational history, and physical examination can aid diagnosis. Electromyography, X-ray, and Magnetic Resonance Imaging may prove useful in select syndromes. Generally, first line therapy of all compressive neuropathies consists of activity modification, rest, splinting, and non-steroidal anti-inflammatory drugs. Many patients experience improvement with conservative measures. For those lacking adequate response, steroid injections may improve symptoms. Surgical release is the last line therapy and has varied outcomes depending on the compression. Carpal Tunnel syndrome (CTS) is the most common, followed by ulnar tunnel syndrome. Open and endoscopic CTS release appear to have similar outcomes. Endoscopic release appears to incur decreased cost baring a low rate of complications, although this is debated in the literature. Additional syndromes of median nerve compression include pronator syndrome (PS), anterior interosseous syndrome, and ligament of Struthers syndrome. Ulnar nerve compressive neuropathies include cubital tunnel syndrome and Guyon’s canal. Radial nerve compressive neuropathies include radial tunnel syndrome and Wartenberg’s syndrome. The goal of this review is to provide all clinicians with guidance on diagnosis and treatment of commonly encountered compressive neuropathies of the forearm.
Wearable Flexible Antenna for UWB On-Body and Implant Communications
Authors: Särestöniemi Mariella , Sonkki Marko , Myllymäki Sami , Pomalaza-Raez Carlos
Published: September 2021

This paper describes the development and evaluation of an on-body flexible antenna designed for an in-body application, as well as on-body communications at ISM and UWB frequency bands. The evaluation is performed via electromagnetic simulations using the Dassault Simulia CST Studio Suite. A planar tissue layer model, as well as a human voxel model from the human abdominal area, are used to study the antenna characteristics next to human tissues. Power flow analysis is presented to understand the power flow on the body surface as well as within the tissues. Simulation results show that this wearable flexible antenna is suitable for in-body communications in the intestinal area, e.g., for capsule endoscopy, in the industrial, scientific, and medical (ISM) band and at lower ultra-wideband (UWB). At higher frequencies, the antenna is suitable for on-body communications as well as in-body communications with lower propagation depth requirements. Additionally, an antenna prototype has been prepared and the antenna performance is verified with several on-body measurements. The measurement results show a good match with the simulation results. The novelty of the proposed antenna is a compact size and the flexible substrate material, which makes it feasible and practical for several different medical diagnosis and monitoring applications.
Elevated IgG Antibody to Aluminum Bound to Human Serum Albumin in Patients with Crohn’s, Celiac and Alzheimer’s Disease
Authors: Vojdani Aristo
Published: September 2021

Aluminum is in our water and food, and is used as an adjuvant in vaccines. About 40% of the ingested dose accumulates within the intestinal mucosa, making the gut the main target of inflammation and autoimmunity; about 1% accumulates in the skeletal system and brain, inducing the cross-linking of amyloid-β-42 peptide and the formation of amyloid aggregates associated with Alzheimer’s disease. To examine whether the accumulation of aluminum in the gut and brain tissues results in neoantigen formation, we bound aluminum compounds to human serum albumin. We used ELISA to measure IgG antibody in 94 different sera from healthy controls and 47 sera from each group of patients: anti-Saccharomyces cerevisiae antibody-positive (Crohn’s), and positive for deamidated α-gliadin and transglutaminase-2 IgA antibodies (celiac disease), autoimmune disorders associated with intestinal tissue antigens. Because earlier studies have shown that aluminum exposure is linked to Alzheimer’s disease etiology, and high aluminum content is detected in Alzheimer’s patients’ brain tissue, we also measured aluminum antibody in the blood of these patients. Additionally, we measured aluminum antibody in the sera of mixed connective tissue disease patients who were positive for antinuclear antibodies, and used them as disease controls. We found significant IgG antibody elevation against all three aluminum compounds in the sera of patients with Crohn’s, celiac and Alzheimer’s disease, but not in patients with mixed connective tissue disease. We concluded that aluminum ingestion and absorption from the GI tract and brain may contribute to Crohn’s, celiac and Alzheimer’s disease, but not to mixed connective tissue disease.
Removal of Protein-Bound Uremic Toxins Using Binding Competitors in Hemodialysis: A Narrative Review
Authors: Maheshwari Vaibhav , Tao Xia , Thijssen Stephan , Kotanko Peter
Published: September 2021

Removal of protein-bound uremic toxins (PBUTs) during conventional dialysis is insufficient. PBUTs are associated with comorbidities and mortality in dialysis patients. Albumin is the primary carrier for PBUTs and only a small free fraction of PBUTs are dialyzable. In the past, we proposed a novel method where a binding competitor is infused upstream of a dialyzer into an extracorporeal circuit. The competitor competes with PBUTs for their binding sites on albumin and increases the free PBUT fraction. Essentially, binding competitor-augmented hemodialysis is a reactive membrane separation technique and is a paradigm shift from conventional dialysis therapies. The proposed method has been tested in silico, ex vivo, and in vivo, and has proven to be very effective in all scenarios. In an ex vivo study and a proof-of-concept clinical study with 18 patients, ibuprofen was used as a binding competitor; however, chronic ibuprofen infusion may affect residual kidney function. Binding competition with free fatty acids significantly improved PBUT removal in pre-clinical rat models. Based on in silico analysis, tryptophan can also be used as a binding competitor; importantly, fatty acids or tryptophan may have salutary effects in HD patients. More chemoinformatics research, pre-clinical, and clinical studies are required to identify ideal binding competitors before routine clinical use.
Early Evaluation of an Ultra-Portable X-ray System for Tuberculosis Active Case Finding
Authors: Vo Luan Nguyen Quang , Codlin Andrew , Ngo Thuc Doan , Dao Thang Phuoc , Dong Thuy Thi Thu , Mo Huong Thi Lan , Forse Rachel , Nguyen Thao Thanh , Cung Cong Van , Nguyen Hoa Binh , Nguyen Nhung Viet , Nguyen Van Van , Tran Ngan Thi , Nguyen Giang Hoai , Qin Zhi Zhen , Creswell Jacob
Published: September 2021

X-ray screening is an important tool in tuberculosis (TB) prevention and care, but access has historically been restricted by its immobile nature. As recent advancements have improved the portability of modern X-ray systems, this study represents an early evaluation of the safety, image quality and yield of using an ultra-portable X-ray system for active case finding (ACF). We reported operational and radiological performance characteristics and compared image quality between the ultra-portable and two reference systems. Image quality was rated by three human readers and by an artificial intelligence (AI) software. We deployed the ultra-portable X-ray alongside the reference system for community-based ACF and described TB care cascades for each system. The ultra-portable system operated within advertised specifications and radiologic tolerances, except on X-ray capture capacity, which was 58% lower than the reported maximum of 100 exposures per charge. The mean image quality rating from radiologists for the ultra-portable system was significantly lower than the reference (3.71 vs. 3.99, p < 0.001). However, we detected no significant differences in TB abnormality scores using the AI software (p = 0.571), nor in any of the steps along the TB care cascade during our ACF campaign. Despite some shortcomings, ultra-portable X-ray systems have significant potential to improve case detection and equitable access to high-quality TB care.
Different Faces of Confinement
Authors: Pasechnik Roman , Šumbera Michal
Published: September 2021

In this review, we provide a short outlook of some of the current most popular pictures and promising approaches to non-perturbative physics and confinement in gauge theories. A qualitative and by no means exhaustive discussion presented here covers such key topics as the phases of QCD matter, the order parameters for confinement, the central vortex and monopole pictures of the QCD vacuum structure, fundamental properties of the string tension, confinement realisations in gauge-Higgs and Yang–Mills theories, magnetic order/disorder phase transition, among others.