bluuebunny/crossref_metadata_2025 huggingface dataset:
Field Measurements for Traffic Noise Reduction in Highway Tunnels Using Closed-Cell Aluminum Foam Board
Authors: Lin Zanquan , Gong Weipeng , Wan Li , Shen Jiajia , Zhang Hu , Huang Juan , Zhu Binbin
Published: January 2022

In order to explore the sound absorption and noise reduction performance of closed-cell aluminum foam in the tunnel, the field test of the sound absorption performance of aluminum foam board was carried out based on the installation of aluminum foam board in the whole line of Haoshanyu Tunnel on Qinglan Expressway. Combined with the existing loudspeaker test and typical tunnel measurements, a new field test method for the noise reduction performance of closed-cell aluminum foam board was proposed for two different working conditions including fixed-point pure tone sound source condition and mobile vehicle sound source condition. The testing results of the new methods were analyzed, and it showed that the closed-cell aluminum foam has good sound absorption property at the frequency spectra between 250 Hz and 1000 Hz, and the farther away from the sound source, the better the sound absorption effect. In the research on the noise reduction effect of actual vehicle, it was found that the insertion loss of the closed-cell foam aluminum board is about 4 dB(A), which indicated that the closed-cell aluminum foam can play a certain noise reduction effect in the tunnel.
How Do German Manufacturers React to the Increasing Societal Pressure for Decarbonisation?
Authors: Buettner Stefan M. , Schneider Christian , König Werner , Mac Nulty Hannes , Piccolroaz Chiara , Sauer Alexander
Published: January 2022

From the perspective of manufacturing companies, the political, media and economic discourse on decarbonisation in the recent years manifests itself as an increasing social expectation of action. In Germany, in particular, this discourse is also being driven forward by powerful companies, respectively sectors, most notably the automotive industry. Against this background, the present paper examines how German manufacturing companies react to rising societal pressure and emerging policies. It examines which measures the companies have taken or plan to take to reduce their carbon footprint, which aspirations are associated with this and the structural characteristics (company size, energy intensity, and sector) by which these are influenced. A mix methods approach is applied, utilising data gathered from approx. 900 companies in context of the Energy Efficiency Index of German Industry (EEI), along with media research focusing on the announced decarbonisation plans and initiatives. We demonstrate that one-size-serves-all approaches are not suitable to decarbonise industry, as the situation and ambitions differ considerably depending on size, energy intensity and sector. Even though the levels of ambition and urgency are high, micro and energy intensive companies, in particular, are challenged. The present research uncovers a series of questions that call for attention to materialise the ambitions and address the challenges outlined.
Quality Factor Enhancement of 650 MHz Superconducting Radio-Frequency Cavity for CEPC
Authors: Sha Peng , Pan Weimin , Zhai Jiyuan , Mi Zhenghui , Jin Song , Liu Baiqi , Dong Chao , He Feisi , Ye Lingxi , He Xiangcong , Zheng Shiao
Published: January 2022

Medium-temperature (mid-T) furnace baking was conducted at 650 MHz superconducting radio-frequency (SRF) cavity for circular electron positron collider (CEPC), which enhanced the cavity unloaded quality factor (Q0) significantly. In the vertical test (2.0 K), Q0 of 650 MHz cavity reached 6.4 × 1010 at 30 MV/m, which is remarkably high at this unexplored frequency. Additionally, the cavity quenched at 31.2 MV/m finally. There was no anti-Q-slope behavior after mid-T furnace baking, which is characteristic of 1.3 GHz cavities. The microwave surface resistance (RS) was also studied, which indicated both very low Bardeen–Cooper–Schrieffer (BCS) and residual resistance. The recipe of cavity process in this paper is simplified and easy to duplicate, which may benefit the SRF community.
Single Evaluation of Use of a Mixed Reality Headset for Intra-Procedural Image-Guidance during a Mock Laparoscopic Myomectomy on an Ex-Vivo Fibroid Model
Authors: Torabinia Matin , Caprio Alexandre , Fenster Tamatha B. , Mosadegh Bobak
Published: January 2022

Uterine fibroids represent the highest prevalence of benign tumors in women, with reports ranging from 4.5% to 68.6%, with a significant bias towards African American women. For uterine fibroids, a significant decision is determining whether fibroids can be successfully removed using minimally invasive (MI) techniques or their removal requires open surgery. Currently, the standard-of-care for intra-procedural visualization for myomectomies is ultrasound, which has low image quality and requires a specially trained assistant. Currently, the state-of-the-art is to obtain a pre-procedural MRI scan of the patient, which can be used for diagnosis and pre-procedural planning. Although proven incredibly useful pre-procedurally, MRI scans are not often used intra-procedurally due to the inconvenient visualization as 2D slices, which are seen on 2D monitors that do not intuitively convey the depth or orientation of the fibroids, as needed to effectively perform myomectomies. To address this limitation, herein, we present the use of a mixed reality headset (i.e., Microsoft HoloLens 2), as a tool for intra-procedural image-guidance during a mock myomectomy of an ex vivo animal uterus. In this work, we created a patient-specific holographic rendering by performing image segmentation of an MRI scan of a custom-made uterine fibroid animal model. A physician qualitatively assessed the usefulness of the renderings for fibroid localization, as compared to the same visualization on a 2D monitor. In conclusion, the use of mixed reality as an intra-procedural image guidance tool for myomectomies was perceived as a better visualization technique that could lead to improvements in MI approaches and make them accessible to patients from lower socioeconomic populations.
About Performance: A Conversation with Richard Schechner
Authors: Madeira Cláudia , Cruzeiro Cristina Pratas , Douglas Anne , Elias Helena
Published: January 2022

Richard Schechner is University Professor Emeritus at New York University (https://tisch [...]
The First Evaluation of Serum Levels of MGP, Gas6 and EGFR after First Dose of Chemotherapy in Lung Cancer
Authors: Crintea Andreea , Dutu Alina Gabriela , Constantin Anne-Marie , Fekete Zsolt , Samasca Gabriel , Lupan Iulia , Florian Ioan Alexandru , Silaghi Ciprian Nicolae , Craciun Alexandra Marioara
Published: January 2022

Background: Vitamin K-dependent proteins (VKDPs) and the epidermal growth factor receptor (EGFR) are involved in lung cancer progression. Therefore, we aimed to study the serum concentration of Matrix Gla protein (MGP), Growth Arrest-specific 6 (Gas6), and EGFR before and after the first cycle of chemotherapy and to investigate how MGP, Gas6, and EGFR are modified after one cycle of chemotherapy. Methods: We performed an observational study on twenty patients diagnosed with lung cancer, by assessing the serum concentration of vitaminK1 (VitK1), MGP, Gas6, and EGFR using the ELISA technique before and after three weeks of the first cycle of chemotherapy. Patients were evaluated using RECIST 1.1 criteria. Results: Serum levels of MGP, Gas6, EGFR, and VK1 before and after treatment were not changed significantly. Regarding the pre-treatment correlation of the MGP values, we found a strong positive relationship between MGP and VK1 pre-treatment values (r = 0.821, 95%CI 0.523; 0.954, p < 0.001). Furthermore, there was a moderately negative correlation between VK1 and EGFR pre-treatment values, with the relationship between them being marginally significant (r = −0.430, 95%CI −0.772; 0.001, p = 0.058). Post-treatment, we found a strong positive relationship between MGP and VK1 post-treatment values (r = 0.758, 95%CI 0.436; 0.900, p < 0.001). We also found a moderate positive relationship between Gas6 and EGFR post-treatment values, but the correlation was only marginally significant (r = 0.442, p = 0.051).
Galectin-3 as a Novel Multifaceted and Not Only Cardiovascular Biomarker in Patients with Psoriasis with Regard to Systemic Treatment—Preliminary Data
Authors: Baran Anna , Kiluk Paulina , Nowowiejska Julia , Kaminski Tomasz W. , Maciaszek Magdalena , Flisiak Iwona
Published: January 2022

Galectin-3 (gal-3) is a multifunctional regulator of various biological processes and diseases, which are common comorbidities in psoriasis. Data regarding potential diagnostic role of gal-3 in psoriasis are insufficient. Serum gal-3 levels were evaluated before and after twelve weeks of treatment with acitretin or methotrexate in 31 patients with plaque-type psoriasis and compared to 11 healthy control group. The mean serum galectin-3 level in patients with psoriasis was significantly higher compared to the control group (p < 0.01). In patients with obesity and long-lasting psoriasis (>20 years) positive relations of gal-3 and PASI were noted. In psoriatics with low gal-3 levels, positive correlations between the gal-3 and BMI, glucose level, and with the latter in short-lasting psoriasis (<20 years) were noted. In the long history of psoriasis, gal-3 was negatively correlated with lipids levels. The Gal-3 level might be a multifaceted modulator of the course of psoriasis and predictive factor of cardiometabolic comorbidities’ development, especially in patients with a long history of the disease or obesity. Patients with low serum gal-3 and short history of psoriasis are presumably at greater risk of diabetes. In patients with long-lasting psoriasis and concomitant obesity, gal-3 may exert a protective role against dyslipidemia or perhaps further CMD development.
Molecular Determinants of Selectivity in Disordered Complexes May Shed Light on Specificity in Protein Condensates
Authors: Monzon Alexander Miguel , Piovesan Damiano , Fuxreiter Monika
Published: January 2022

Biomolecular condensates challenge the classical concepts of molecular recognition. The variable composition and heterogeneous conformations of liquid-like protein droplets are bottlenecks for high-resolution structural studies. To obtain atomistic insights into the organization of these assemblies, here we have characterized the conformational ensembles of specific disordered complexes, including those of droplet-driving proteins. First, we found that these specific complexes exhibit a high degree of conformational heterogeneity. Second, we found that residues forming contacts at the interface also sample many conformations. Third, we found that different patterns of contacting residues form the specific interface. In addition, we observed a wide range of sequence motifs mediating disordered interactions, including charged, hydrophobic and polar contacts. These results demonstrate that selective recognition can be realized by variable patterns of weakly defined interaction motifs in many different binding configurations. We propose that these principles also play roles in determining the selectivity of biomolecular condensates.
Revertant Mosaicism in Epidermolysis Bullosa
Authors: Meyer-Mueller Cameron , Osborn Mark J. , Tolar Jakub , Boull Christina , Ebens Christen L.
Published: January 2022

Epidermolysis bullosa (EB) is a group of genetic blistering diseases characterized by mechanically fragile skin and mucocutaneous involvement. Historically, disease management has focused on supportive care. The development of new genetic, cellular, and recombinant protein therapies has shown promise, and this review summarizes a unique gene and cell therapy phenomenon termed revertant mosaicism (RM). RM is the spontaneous correction of a disease-causing mutation. It has been reported in most EB subtypes, some with relatively high frequency, and has been observed in both keratinocytes and fibroblasts. RM manifests as identifiable patches of unaffected, blister-resistant skin and can occur through a variety of molecular mechanisms, including true back mutation, intragenic crossover, mitotic gene conversion, and second-site mutation. RM cells represent a powerful autologous platform for therapy, and leveraging RM cells as a therapeutic substrate may avoid the inherent mutational risks of gene therapy/editing. However, further examination of the genomic integrity and long-term functionality of RM-derived cells, as well in vivo testing of systemic therapies with RM cells, is required to realize the full therapeutic promise of naturally occurring RM in EB.
Artificial-Intelligence-Assisted Discovery of Genetic Factors for Precision Medicine of Antiplatelet Therapy in Diabetic Peripheral Artery Disease
Authors: Yeh Chi-Hsiao , Chou Yi-Ju , Tsai Tsung-Hsien , Hsu Paul Wei-Che , Li Chun-Hsien , Chan Yun-Hsuan , Tsai Shih-Feng , Ng Soh-Ching , Chou Kuei-Mei , Lin Yu-Ching , Juan Yu-Hsiang , Fu Tieh-Cheng , Lai Chi-Chun , Sytwu Huey-Kang , Tsai Ting-Fen
Published: January 2022

An increased risk of cardiovascular events was identified in patients with peripheral artery disease (PAD). Clopidogrel is one of the most widely used antiplatelet medications. However, there are heterogeneous outcomes when clopidogrel is used to prevent cardiovascular events in PAD patients. Here, we use an artificial intelligence (AI)-assisted methodology to identify genetic factors potentially involved in the clopidogrel-resistant mechanism, which is currently unclear. Several discoveries can be pinpointed. Firstly, a high proportion (>50%) of clopidogrel resistance was found among diabetic PAD patients in Taiwan. Interestingly, our result suggests that platelet function test-guided antiplatelet therapy appears to reduce the post-interventional occurrence of major adverse cerebrovascular and cardiac events in diabetic PAD patients. Secondly, AI-assisted genome-wide association study of a single-nucleotide polymorphism (SNP) database identified a SNP signature composed of 20 SNPs, which are mapped into 9 protein-coding genes (SLC37A2, IQSEC1, WASHC3, PSD3, BTBD7, GLIS3, PRDM11, LRBA1, and CNR1). Finally, analysis of the protein connectivity map revealed that LRBA, GLIS3, BTBD7, IQSEC1, and PSD3 appear to form a protein interaction network. Intriguingly, the genetic factors seem to pinpoint a pathway related to endocytosis and recycling of P2Y12 receptor, which is the drug target of clopidogrel. Our findings reveal that a combination of AI-assisted discovery of SNP signatures and clinical parameters has the potential to develop an ethnic-specific precision medicine for antiplatelet therapy in diabetic PAD patients.
Tween 80 Improves the Acid-Fast Bacilli Quantification in the Magnetic Nanoparticle-Based Colorimetric Biosensing Assay (NCBA)
Authors: Gordillo-Marroquín Cristina , Sánchez-Pérez Héctor J. , Gómez-Velasco Anaximandro , Martín Miguel , Guillén-Navarro Karina , Vázquez-Marcelín Janeth , Gómez-Bustamante Adriana , Jonapá-Gómez Letisia , Alocilja Evangelyn C.
Published: January 2022

Despite its reduced sensitivity, sputum smear microscopy (SSM) remains the main diagnostic test for detecting tuberculosis in many parts of the world. A new diagnostic technique, the magnetic nanoparticle-based colorimetric biosensing assay (NCBA) was optimized by evaluating different concentrations of glycan-functionalized magnetic nanoparticles (GMNP) and Tween 80 to improve the acid-fast bacilli (AFB) count. Comparative analysis was performed on 225 sputum smears: 30 with SSM, 107 with NCBA at different GMNP concentrations, and 88 with NCBA-Tween 80 at various concentrations and incubation times. AFB quantification was performed by adding the total number of AFB in all fields per smear and classified according to standard guidelines (scanty, 1+, 2+ and 3+). Smears by NCBA with low GMNP concentrations (≤1.5 mg/mL) showed higher AFB quantification compared to SSM. Cell enrichment of sputum samples by combining NCBA-GMNP, incubated with Tween 80 (5%) for three minutes, improved capture efficiency and increased AFB detection up to 445% over SSM. NCBA with Tween 80 offers the opportunity to improve TB diagnostics, mainly in paucibacillary cases. As this method provides biosafety with a simple and inexpensive methodology that obtains results in a short time, it might be considered as a point-of-care TB diagnostic method in regions where resources are limited.
Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications
Authors: Jacquemin Valerie , Antoine Mathieu , Dom Geneviève , Detours Vincent , Maenhaut Carine , Dumont Jacques E.
Published: January 2022

Though heterogeneity of cancers is recognized and has been much discussed in recent years, the concept often remains overlooked in different routine examinations. Indeed, in clinical or biological articles, reviews, and textbooks, cancers and cancer cells are generally presented as evolving distinct entities rather than as an independent heterogeneous cooperative cell population with its self-oriented biology. There are, therefore, conceptual gaps which can mislead the interpretations/diagnostic and therapeutic approaches. In this short review, we wish to summarize and discuss various aspects of this dynamic evolving heterogeneity and its biological, pathological, clinical, diagnostic, and therapeutic implications, using thyroid carcinoma as an illustrative example.
Repositioning Fenofibrate to Reactivate p53 and Reprogram the Tumor-Immune Microenvironment in HPV+ Head and Neck Squamous Cell Carcinoma
Authors: O’Neill W. Quinn , Xie Xiujie , Gui Shanying , Yu Heping , Davenport Jacqueline , Cartwright Thomas , Storl-Desmond Marta , Ryu Esther , Chan Ernest R. , Cao Shufen , Fu Pingfu , Teknos Theodoros N. , Pan Quintin
Published: January 2022

Human papillomavirus-associated head and neck squamous cell carcinoma (HPV+ HNSCC) is recognized as a distinct disease with unique etiology and clinical features. Current standard of care therapeutic modalities are identical for HPV+ and HPV− HNSCC and thus, there remains an opportunity to develop innovative pharmacologic approaches to exploit the inherent vulnerabilities of HPV+ HNSCC. In this study, using an inducible HPVE6E7 knockdown system, we found that HPV+ HNSCC cells are addicted to HPVE6E7, such that loss of these viral oncogenes impaired tumorigenicity in vitro and in vivo. A number of druggable pathways, including PPAR and Wnt, were modulated in response to HPVE6E7 loss. Fenofibrate showed significant anti-proliferative effects in a panel of HPV+ cancer cell lines. Additionally, fenofibrate impaired tumor growth as monotherapy and potentiated the activity of cisplatin in a pre-clinical HPV+ animal model. Systemic fenofibrate treatment induced p53 protein accumulation, and surprisingly, re-programmed the tumor-immune microenvironment to drive immune cell infiltration. Since fenofibrate is FDA-approved with a favorable long-term safety record, repositioning of this drug, as a single agent or in combination with cisplatin or checkpoint blockade, for the HPV+ HNSCC setting should be prioritized.
Risk of New Primary Cancer in Patients with Posterior Uveal Melanoma: A National Cohort Study
Authors: Bagger Mette , Albieri Vanna , Hindso Tine Gadegaard , Wadt Karin , Heegaard Steffen , Andersen Klaus Kaae , Kiilgaard Jens Folke
Published: January 2022

Background: Studies on the risk of new primary cancer in patients with posterior uveal melanoma (UM) have produced conflicting results, and the role of socioeconomic status (SES) is unknown. The purpose of this population-based matched cohort study was to determine the risk of new primary cancer following the diagnosis of posterior UM. Methods: 2179 patients with posterior UM 1968–2016 and 22,717 matched controls without cancer were included. Incidence and time-dependent hazard ratio (HR) of new primary cancer were described, and the effect of SES was emphasized in a sub-cohort. Results: The incidence of new primary cancer was increased in patients with posterior UM, rate ratio (RR) 1.21 (95% CI: 1.08; 1.35), but the specific cancer types did not differ compared to the controls. The rate of new primary cancer following the diagnosis of posterior UM was significantly increased 2–5 years (HR 1.49 (95% CI: 1.23; 1.80)) and 11–15 years (HR: 1.49 (95% CI: 1.12; 1.99)), and adjusting for SES did not change the rate (HR 1.35 (95% CI:1.20; 1.55)). Conclusions: Patients with posterior UM have an increased risk of new primary cancer independent of SES. No difference in incidence of specific cancer type was observed compared to the control group.
Role of Lactobacillus reuteri DSM 17938 on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based Study
Authors: Wadhwa Arun , Kesavelu Dhanasekhar , Kumar Kishore , Chatterjee Pallab , Jog Pramod , Gopalan Sarath , Paul Rudra , Veligandla Krishna Chaitanya , Mehta Suyog , Mane Amey , Pandit Sucheta , Rathod Rahul , Jayan Sushma , Mitra Monjori
Published: January 2022

Background: Infantile colic is characterized by prolonged periods of inconsolable, incessant crying and persistent fussing in an otherwise healthy infant. It is a self-limiting condition, but causes significant stress to mothers. AIM: To observe the role of Lactobacillus reuteriDSM 17938 in reducing crying time in colicky infants in routine clinical practice. Methods: This was a prospective observational multicentric clinic-based study. Each practitioner included approximately 30 infants < 5 months of age with infantile colic who were prescribed L. reuteri DSM 17938 for a period of 21 days. There were four physical consultations and two telephonic consultations. The parents were given a daily diary to record the duration of crying and fussing episodes and a questionnaire was administered during the consultations. Results: A total of 120 infants with a mean age of 56.9 ± 34.2 days were included in this 28-day study. The mean crying time as reported by the parents in the subject diary reduced from 248.2 ± 101.2 min, 95% CI: 229.45, 266.94 at baseline to 45.6 ± 79.1 min 95% CI: 31.02, 60.31 at study end (P < 0.01). The clinical response (defined as reduction of 50% in crying time) was observed in 85% of subjects at study end. The fussiness and parental perception of colic recorded during the consultations were reduced by 66% and 72%, respectively, at study end. The maternal depression scores were reduced to 63% at study end. Conclusion: L. reuteri DSM 17938 was associated with a significant reduction in crying time in colicky infants, and showed improvement in maternal depression.
Preparation of Very Thin Zinc Oxide Films by Liquid Deposition Process: Review of Key Processing Parameters
Authors: Khiari Mouna , Gilliot Mickaël , Lejeune Michaël , Lazar Florica , Hadjadj Aomar
Published: January 2022

We used sol-gel and spin-coating in the original configuration of a liquid deposition process to synthesize particularly thin ZnO films (<100 nm) with nano-granular morphology, high grain orientation and variable optical properties. The concentration of the zinc salt, the concentration of the chelating agent, the nature of the solvent and the substrate material have been identified as key parameters that determine the microstructure of the deposited layer and thus its final properties. The thorough and practical examination of the effects of the synthesis parameters evidenced a three-step growth mechanism for these ZnO thin films: (i) a reaction of precursors, (ii) a formation of nuclei, and (iii) a coalescence of nanoparticles under thermal annealing. The growth of these very thin films is thus conditioned by the interaction between the liquid phase and the substrate especially during the initial steps of the spin coating process. Such thin ZnO films with such nano-granular morphology may be of great interest in various applications, especially those requiring a large active surface area.
Investigation of the Adhesion Strength, Fracture Toughness, and Stability of M/Cr2N and M/V2N (M = Ti, Ru, Ni, Pd, Al, Ag, and Cu) Interfaces Based on First-Principles Calculations
Authors: Wang Miao , Liu Gang , Huang Min , Fu Yabo , Lin Changhong , Wu Jianbo , Levchenko Vladimir A.
Published: January 2022

Obtaining detailed information regarding the interfacial characteristics of metal/hexagonal-TMN composites is imperative for developing these materials with optimal mechanical properties. To this end, we systematically investigate the work of adhesion, fracture toughness, and interfacial stability of M/Cr2N and M/V2N interfaces using first-principles calculations. The orientation (0001) of hexagonal phases and (111) of fcc phases are selected as the interface orientations. Accordingly, we construct M/Cr2N interface models by considering 1N, 2N, and Cr terminations of Cr2N(0001), as well as two stacking sequences (top and hollow sites) for the 1N- and 2N-terminated interface models, respectively. The M/V2N interface models are constructed in the same way. The V-terminated Ni/V2N interface is demonstrated to provide a good combination of the work of adhesion, fracture toughness, and interfacial stability. Therefore, the Ni/V2N interface model can be regarded as the preferred configuration among the metal/hexagonal-TMN interface models considered. The present results offer a practical perspective for tailoring the interfaces in metal/hexagonal-TMN composite materials to obtain improved mechanical properties.
Electrode Materials for Supercapacitors in Hybrid Electric Vehicles: Challenges and Current Progress
Authors: Rajagopal Sivakumar , Pulapparambil Vallikkattil Rameez , Mohamed Ibrahim M. , Velev Dimiter Georgiev
Published: January 2022

For hybrid electric vehicles, supercapacitors are an attractive technology which, when used in conjunction with the batteries as a hybrid system, could solve the shortcomings of the battery. Supercapacitors would allow hybrid electric vehicles to achieve high efficiency and better power control. Supercapacitors possess very good power density. Besides this, their charge-discharge cycling stability and comparatively reasonable cost make them an incredible energy-storing device. The manufacturing strategy and the major parts like electrodes, current collector, binder, separator, and electrolyte define the performance of a supercapacitor. Among these, electrode materials play an important role when it comes to the performance of supercapacitors. They resolve the charge storage in the device and thus decide the capacitance. Porous carbon, conductive polymers, metal hydroxide, and metal oxides, which are some of the usual materials used for the electrodes in the supercapacitors, have some limits when it comes to energy density and stability. Major research in supercapacitors has focused on the design of stable, highly efficient electrodes with low cost. In this review, the most recent electrode materials used in supercapacitors are discussed. The challenges, current progress, and future development of supercapacitors are discussed as well. This study clearly shows that the performance of supercapacitors has increased considerably over the years and this has made them a promising alternative in the energy sector.
Tin Whisker Growth Suppression Using NiO Sublayers Fabricated by Dip Coating
Authors: Buchanan Jacob D. , Borra Vamsi , Islam Md Maidul , Georgiev Daniel G. , Itapu Srikanth
Published: January 2022

Whiskers are small crystalline growths, which can grow from certain metals or alloys. Reaching up to several millimeters long, whiskers have the potential to cause device failures due to short circuits and contamination by debris. Tin (Sn) is one such metal that is particularly prone to whisker development. Until the 2006 RoHS Initiative, lead (Pb) was added to tin in small amounts (up to 2%) to greatly reduce the growth of whiskers. Since then, however, industry has switched to lead-free tin solders and coatings, and the issue of whisker growth on tin has attracted new interest. A reactive-sputtering-deposited nickel oxide sublayer was shown recently to strongly suppress the growth of whiskers from an overlaying tin layer. This paper reports on using nickel oxide films, obtained by a sol–gel dip coating method, as whisker suppressing sublayers. The proposed method is simple, low-cost, and can easily be scaled up for manufacturing purposes. The properties of the sol–gel deposited nickel oxide film were examined using SEM, EDS, and Raman spectroscopy. Samples containing the nickel oxide sublayer were observed through SEM periodically over several months to examine the surfaces for whisker development, and the results show that such layers can be very effective in suppressing whisker growth.
Layers of Meaning and Evolution of Cultural Identity: The Case of Wind Towers in Dubai
Authors: Assi Eman
Published: January 2022

Place identity is an important constituent of general cultural identity, in that it provides its share of continuity, sustainability, and character to the built environment. The image of cultural heritage is stored knowledge that reflects the identity of a specific culture. In the formation of a place, some features gain identity with the environment. This study aims to explore the evolving image formation of wind towers in Dubai, and how this image is related to the concept of meaning and cultural identity of the place. This study focuses on the process of place identity formation and its relation to the evolving cultural values of society, as well as how it is applied to the changing meaning of cultural heritage objects. Based on the value assessment approach, different examples of wind towers, taken from either traditional houses or contemporary buildings influenced by the local architecture in Dubai, the author attempted to study how the interpretation and meaning of wind towers has evolved through time, thus influencing the cultural identity of Dubai city. This study is based on qualitative research. It concludes that a wind tower, as a cooling device, represents a unique example of an evolving creative process of architectural expression, resulting from the social and cultural complexity of the Persian Gulf in the early twentieth century. They were introduced through commercial exchange, adapted by the mercantile community, and integrated into local cultural systems—thus creating new architectural features and urban character—and reintroduced as a modern symbol of cultural identity for Dubai and the UAE.
Improving the Performance of Mortars Made from Recycled Aggregates by the Addition of Zeolitised Cineritic Tuff
Authors: Martín Domingo A. , Costafreda Jorge L. , Costafreda Jorge L. , Presa Leticia
Published: January 2022

Metropolitan construction and demolition waste (CDW) is currently an important source of recycled materials that, despite having completed their useful life cycle, can be reincorporated into the circular economy process (CEP); however, the recycling process is very selective, and waste material is not always fully satisfactory due to the intrinsic nature of the waste. This work aims to demonstrate and establish how to increase the effectiveness of the construction and demolition waste in more resistant mortars, by mixing it with zeolitised cinerite tuff (ZCT) at varying normalised proportions. To attain the objectives of this research, a series of tests were done: First, a chemical, physical and mineralogical characterisation of the CDW and the ZCT through XRF, XRD, SEM and granulometric methods. Second, a technological test was made to determine the mechanical strength at 7, 28 and 90 days of specimens made with Portland cement (PC) and mixtures of PC/CDW, PC/ZCT, and PC/CDW-ZCT. The results obtained through the characterisation methods showed that the sample of construction and demolition waste consisted of the main phase made of portlandite and tobermorite, and by a secondary phase consisting of quartz, ettringite and calcite; whereas the ZCT has a main phase of mordenite and a secondary phase of smectite (montmorillonite), amorphous materials consisting of devitrified volcanic glass, quartz and plagioclase. Mechanical strength tests established that specimens made with PC/CDW mixtures have very discreet compressive strength values up to 44 MPa at 90 days, whereas specimens made with PC/ZCT mixtures achieved a remarkably high mechanical strength consisting of 68.5 MPa. However, the most interesting conclusion in this research is the good result obtained in mechanical strength of the specimens made up of mixtures of PC/CDW-ZCT, which increased from 52.5 to 62 MPa at 90 days of curing; this fact establishes the positive influence of ZCT on waste in the mortar mixtures, which permits the authors to establish that the objective of the work has been fulfilled. Finally, it can be argued that the results obtained in this research could contribute to more effective use of construction and demolition waste in metropolitan areas.
Who Could Be Blamed in the Case of Discrepant Histology and Serology Results for Helicobacter pylori Detection?
Authors: Skrebinska Sabine , Megraud Francis , Daugule Ilva , Santare Daiga , Isajevs Sergejs , Liepniece-Karele Inta , Bogdanova Inga , Rudzite Dace , Vangravs Reinis , Kikuste Ilze , Vanags Aigars , Tolmanis Ivars , Savcenko Selga , Alix Chloé , Herrero Rolando , Park Jin Young , Leja Marcis
Published: January 2022

Background. Discrepancies between histology and serology results for Helicobacter pylori detection could be caused by a variety of factors, including a biopsy sampling error, expertise of the pathologist, natural loss of infection due to advanced atrophy, or a false-positive serology in the case of a previous infection, since antibodies may be present in blood following recovery from the infection. Aims. To identify true H. pylori-positive individuals in discrepant cases by serology and histology using real time polymerase chain reaction (RT-PCR) as a gold standard. Methods. Study subjects with discrepant histology and serology results were selected from the GISTAR pilot study data base in Latvia. Subjects having received previous H. pylori eradication therapy or reporting use of proton pump inhibitors, antibacterial medications, or bismuth containing drugs one month prior to upper endoscopy were excluded. We compared the discrepant cases to the corresponding results of RT-PCR performed on gastric biopsies. Results. In total, 97 individuals with discrepant results were identified: 81 subjects were serology-positive/histology-negative, while 16 were serology-negative/histology-positive. Among the serology-positive/histology-negative cases, 64/81 (79.0%) were false-positives by serology and, for the majority, inflammation was absent in all biopsies, while, in the serology-negative/histology-positive group, only 6.2% were proven false-positives by histology. Conclusions. Among this high H. pylori prevalent, middle-aged population, the majority of discrepant cases between serology and histology were due to false positive-serology, rather than false-negative histology. This confirms the available evidence that the choice of treatment should not be based solely on the serological results, but also after excluding previous, self-reported eradication therapy.
Review of Machine Learning Applications Using Retinal Fundus Images
Authors: Jeong Yeonwoo , Hong Yu-Jin , Han Jae-Ho
Published: January 2022

Automating screening and diagnosis in the medical field saves time and reduces the chances of misdiagnosis while saving on labor and cost for physicians. With the feasibility and development of deep learning methods, machines are now able to interpret complex features in medical data, which leads to rapid advancements in automation. Such efforts have been made in ophthalmology to analyze retinal images and build frameworks based on analysis for the identification of retinopathy and the assessment of its severity. This paper reviews recent state-of-the-art works utilizing the color fundus image taken from one of the imaging modalities used in ophthalmology. Specifically, the deep learning methods of automated screening and diagnosis for diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma are investigated. In addition, the machine learning techniques applied to the retinal vasculature extraction from the fundus image are covered. The challenges in developing these systems are also discussed.
First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania
Authors: Stan Iustina Violeta , Miron Victor Daniel , Vangheli Ioana Alexandra , Gheorghiu Radu Marian , Streinu-Cercel Anca , Săndulescu Oana , Craiu Mihai
Published: January 2022

Patients with chronic lung conditions, including cystic fibrosis, may be prone to severe COVID-19. Therefore, therapeutic intervention should be prompt and tailored to all associated comorbidities. We report the case of a 17-year-old male adolescent with cystic fibrosis and multiple chronic conditions (bronchiectasis, exocrine pancreatic insufficiency, chronic multidrug resistant Pseudomonas aeruginosa colonization, nasal polyposis, chronic sinusitis, ventricular extrasystoles and multiple drug allergies), who presented with an acute episode of productive cough, and was confirmed with moderate COVID-19 based on positive RT-PCR for SARS-CoV-2 and lung imaging showing isolated foci of interstitial pneumonia. Intravenous treatment with the monoclonal antibody cocktail casirivimab and imdevimab was administered. The evolution was favorable, with rapid remission of the inflammatory syndrome and gradual decrease of cough, without progression to severe or critical COVID-19, but with complications such as repeated hemoptysis, which was due to the patient’s underlying conditions, and which required close monitoring for timely adjustment of the patient’s chronic treatment.
SuSy-EnGaD: Surveillance System Enhanced by Games of Drones
Authors: Stolfi Daniel H. , Brust Matthias R. , Danoy Grégoire , Bouvry Pascal
Published: January 2022

In this article, we propose SuSy-EnGaD, a surveillance system enhanced by games of drones. We propose three different approaches to optimise a swarm of UAVs for improving intruder detection, two of them featuring a multi-objective optimisation approach, while the third approach relates to the evolutionary game theory where three different strategies based on games are proposed. We test our system on four different case studies, analyse the results presented as Pareto fronts in terms of flying time and area coverage, and compare them with the single-objective optimisation results from games. Finally, an analysis of the UAVs trajectories is performed to help understand the results achieved.
The Effect of the Protein Synthesis Entropy Reduction on the Cell Size Regulation and Division Size of Unicellular Organisms
Authors: Razavi Mohammad , Saberi Fathi Seyed Majid , Tuszynski Jack Adam
Published: January 2022

The underlying mechanism determining the size of a particular cell is one of the fundamental unknowns in cell biology. Here, using a new approach that could be used for most of unicellular species, we show that the protein synthesis and cell size are interconnected biophysically and that protein synthesis may be the chief mechanism in establishing size limitations of unicellular organisms. This result is obtained based on the free energy balance equation of protein synthesis and the second law of thermodynamics. Our calculations show that protein synthesis involves a considerable amount of entropy reduction due to polymerization of amino acids depending on the cytoplasmic volume of the cell. The amount of entropy reduction will increase with cell growth and eventually makes the free energy variations of the protein synthesis positive (that is, forbidden thermodynamically). Within the limits of the second law of thermodynamics we propose a framework to estimate the optimal cell size at division.
Hybridization of PSO for the Optimal Coordination of Directional Overcurrent Protection Relays
Authors: Habib Kashif , Lai Xinquan , Wadood Abdul , Khan Shahbaz , Wang Yuheng , Xu Siting
Published: January 2022

In the electrical power system, the coordination of directional overcurrent protection relays (DOPR) plays a preeminent role in protecting the electrical power system with the help of primary and back up protection to keep the system vigorous and to avoid unnecessary interruption. The coordination between these relays should be pursued at optimal value to minimize the total operating time of all main relays. The coordination of directional overcurrent relay is a highly constrained optimization problem. The DOPR problem has been solved by using a hybridized version of particle swarm optimization (HPSO). The hybridization is achieved by introducing simulated annealing (SA) in original PSO to avoid being trapped in local optima and successfully searching for a global optimum solution. The HPSO has been successfully applied to five case studies. Furthermore, the obtained results outperform the other traditional and state of the art techniques in terms of minimizing the total operating of DOPR and convergence characteristics, and require less computational time to achieve the global optimum solution.
Numerical Simulation of Effective Hole Cleaning by Using an Innovative Elliptical Drillpipe in Horizontal Wellbore
Authors: Ju Guoshuai , Yan Tie , Sun Xiaofeng
Published: January 2022

In the drilling of horizontal wells, the drill cuttings tend to settle down on the low side of the annulus due to gravity and form a stationary bed, which results in hole cleaning problems. In this paper, a novel type of drillpipe with an elliptical shape was proposed to alleviate inadequate hole cleaning during the drilling of horizontal wells. A three-dimensional computational fluid dynamic (CFD) Eulerian-Eulerian approach with the Realizable k-ɛ turbulence model was developed to predict the solid–liquid two-phase flow in the annular space. Numerical examples were given to investigate the influence of different parameters on cuttings’ transport behavior, and the elliptical drillpipe was compared with the circular drillpipe. The annular cuttings concentration, annular pressure drop, and hole cleaning efficiency were evaluated. The numerical results clarify the potential of the elliptical drillpipe to enhance the hole cleaning efficiency without significantly increasing the annular pressure drop. Due to the swirl flow and secondary flow caused by the rotation of the curvature wall, the swaying phenomenon of drill cuttings’ distribution along the rotation direction of drillpipe was observed and enhanced the cuttings transport ability. Using the elliptical drillpipe as a joint-type tool can improve hole cleaning performance. Under the optimum conditions applied in this study, the hole cleaning efficiency increased by nearly 18%.
High Level of Phenotypic Differentiation of Common Yew (Taxus baccata L.) Populations in the North-Western Part of the Balkan Peninsula
Authors: Tumpa Katarina , Liber Zlatko , Šatović Zlatko , Medak Jasnica , Idžojtić Marilena , Vidaković Antonio , Vukelić Joso , Šapić Irena , Nikl Patricija , Poljak Igor
Published: January 2022

Common or English yew (Taxus baccata L., Taxaceae) is a conifer species, native to Europe, northern Africa, Asia Minor and Caucasus. It is a dioecious, wind-pollinated and animal-dispersed tree, known for its high-quality wood and medicinal properties, albeit poisonous. The species is rare and has been legally protected at the European and national levels. In addition, its low population density and disjunct character of distribution have reinforced the need for its protection as regeneration is mostly lacking. The aim of this study was to phenotypically characterise the north-western Balkan yew populations. Phenotypic diversity was examined for seven populations, using morphometric analysis of nine phenotypic traits of needles. Descriptive and multivariate statistical analyses were conducted to evaluate the inter- and intrapopulation variability. In addition, to test correlations between geographic, climatic and phenotypic data, Mantel test was used. We identified a geographic structure across studied populations that exhibited high levels of variability on intra- and interpopulation levels. Two groups of populations have been defined and are consistent with previously described genetic divergent lineages from separate refugia. In addition, a significant correlation between phenotypic and geographic data were revealed, i.e., isolation by distance (IBD). However, the Mantel test revealed no significant correlation between morphometric and environmental data. In conclusion, our data reveal that the historical events and persistent IBD acted in combination to produce the morphological patterns observed in common yew populations in the north-western part of the Balkan Peninsula. Finally, we suggested conservation measures to be implemented on a stand level, with habitat preservation as the main goal. In addition, ex situ conservation should be considered, both in the form of collections and urban planting, as both provide additional gene pool reserves.
Multi-Mineral Element Profiles in Genuine and “Bathing” Cultured Chinese Mitten Crabs (Eriocheir sinensis) in Yangcheng Lake, China
Authors: Xue Junren , Jiang Tao , Chen Xiubao , Liu Hongbo , Yang Jian
Published: January 2022

The authentication of high-quality fishery products originating from specific geographical regions is urgently needed worldwide. Chinese mitten crabs (Eriocheir sinensis), originating from Yangcheng Lake, are prime counterfeiting targets for the same reasons. Foreign crabs that are cultured briefly in the lake, known as “bathed” crabs, are illegally marketed as natives, negatively impacting the product quality. To establish a method for distinguishing “bathed” and genuine crabs, in this paper we conduct a comparative investigation by an Agilent 7500ce ICP-MS on multi-mineral element profiling of the third pereiopod from genuine and one month deliberately “bathing” cultured crabs. The profiles of 11 elements were significantly different between the genuine and foreign crabs before and after bathing. The discriminant analysis reached 100% accuracy to separate the genuine and “bathed” crabs into different groups. Bathing culture was unable to converge element profiles between the genuine and foreign crabs. The biogeochemical profiles can be effective for distinguishing “bathed” crabs.
Computational Approach for the Fluid-Structure Interaction Design of Insect-Inspired Micro Flapping Wings
Authors: Ishihara Daisuke
Published: January 2022

A flight device for insect-inspired flapping wing nano air vehicles (FWNAVs), which consists of the micro wings, the actuator, and the transmission, can use the fluid-structure interaction (FSI) to create the characteristic motions of the flapping wings. This design will be essential for further miniaturization of FWNAVs, since it will reduce the mechanical and electrical complexities of the flight device. Computational approaches will be necessary for this biomimetic concept because of the complexity of the FSI. Hence, in this study, a computational approach for the FSI design of insect-inspired micro flapping wings is proposed. This approach consists of a direct numerical modeling of the strongly coupled FSI, the dynamic similarity framework, and the design window (DW) search. The present numerical examples demonstrated that the dynamic similarity framework works well to make different two FSI systems with the strong coupling dynamically similar to each other, and this framework works as the guideline for the systematic investigation of the effect of characteristic parameters on the FSI system. Finally, an insect-inspired micro flapping wing with the 2.5-dimensional structure was designed using the proposed approach such that it can create the lift sufficient to support the weight of small insects. The existing area of satisfactory design solutions or the DW increases the fabricability of this wing using micromachining techniques based on the photolithography in the micro-electro-mechanical systems (MEMS) technology. Hence, the proposed approach will contribute to the further miniaturization of FWNAVs.