bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing healthcare data privacy and security: A comparative study of regulations and best practices in the US and Nigeria
Authors: Benjamin Idoko  , Jennifer Amaka Alakwe  , Ogochukwu Judith Ugwu  , Joy Ene Idoko  , Fedora Ochanya Idoko  , Victoria Bukky Ayoola  , Ejembi Victor Ejembi  , Tomilola Adeyinka
Published: July 2024

The imperative for robust healthcare data privacy and security is escalating as healthcare systems worldwide are increasingly digitized. This review paper presents a comprehensive comparative analysis of the regulatory frameworks, challenges, and best practices related to healthcare data privacy and security in the United States and Nigeria. By examining the Health Insurance Portability and Accountability Act (HIPAA) in the US and the Nigeria Data Protection Regulation (NDPR) alongside other local regulations, this study highlights the nuances of each country's approach to safeguarding patient data. The analysis extends to the effectiveness of technological solutions like encryption and blockchain, and assesses the role of governance in policy implementation. Case studies from both nations offer insights into successful strategies and underscore the gaps and opportunities for cross-country learning and improvement. The paper concludes with targeted recommendations for policymakers and healthcare providers, aiming to strengthen the security measures and propose areas for further research and development in healthcare data management. This comparative study not only sheds light on current practices but also charts a course for future collaborative efforts to enhance data privacy and security in healthcare on a global scale.
Advancements in health information technology and their influence on nursing practice in the USA
Authors: Benjamin Idoko  , Joy Ene Idoko  , Ogochukwu Judith Ugwu  , Jennifer Amaka Alakwe  , Fedora Ochanya Idoko  , Victoria Bukky Ayoola  , Ejembi Victor Ejembi  , Tomilola Adeyinka
Published: July 2024

Advancements in Health Information Technology (HIT) have significantly transformed nursing practice in the USA, driving improvements in patient care, clinical decision-making, and overall healthcare efficiency. This review paper explores the various technological advancements, including Electronic Health Records (EHRs), telehealth, mobile health applications, and artificial intelligence, and their profound influence on nursing. It examines the benefits these technologies bring to patient safety, nursing workflow, and education, while also addressing the challenges faced in their adoption. Through case studies, the paper illustrates real-world applications of HIT in nursing, highlighting both successes and areas for improvement. The review concludes with a discussion on future trends and recommendations for integrating HIT into nursing practice, emphasizing the need for ongoing innovation and policy support to maximize the potential of these technologies. This paper aims to provide a comprehensive understanding of how HIT is reshaping the landscape of nursing in the USA, ultimately enhancing the quality of healthcare delivery.
Beta-blockers and their impact on blood pressure and heart rate
Authors: Halida Mahmutbegović Poljaković  , Mithat Tabaković  , Halid Mahmutbegović  , Elvedin Osmanović  , Aldijana Mahmutović Milićević
Published: July 2024

The aim of the study is to determine the impact of beta-blockers on blood pressure and heart rate in patients that use these drugs during treatment of arterial hypertension. The sample included 120 patients from the "Dom Zdravlja'' Živinice. Patients were monitored for 3 years. No statistically significant difference in the values of systolic and diastolic blood pressure as well as heart rate in patients using beta-blockers and other groups of antihypertensives was determined during monitoring period after 12, 24 and 36 months of treatment. Also, there was no statistically significant impact of the applied therapy on these values in the observed time intervals. In order to determine statistically significant difference between treatments, we compared their values sorted by time. No statistically significant difference was found in systolic blood pressure and heart rate between groups, but a statistically significant difference in diastolic blood pressure was found between groups after 12 and 36 months of therapy. No statistically significant difference was found in the values of systolic and diastolic blood pressure, as well as heart rate after 12, 24 and 36 months of treatment by comparing the same values within the group of beta-blockers (patients using bisoprolol and carvedilol and patients using other beta-blockers). Also, there was no statistically significant impact of the applied therapy on the change of these values during observed period. In order to determine statistically significant difference between the treatments, we compared their values sorted by time. There was no statistically significant difference in the values of systolic and diastolic blood pressure and heart rate between the groups. Also, the condition of patients who used beta-blockers in the treatment of hypertension did not require increasing the dose in order to achieve the required parameters. Therefore, in our research, haven't been proven the worse effect of beta-blockers on blood pressure and heart rate when compared to other antihypertensive drugs. Also, all drugs showed equal effectiveness within the group of beta-blockers.
Effect of Augmented Reality (AR) and Virtual Reality (VR) experiences on customer engagement and purchase behavior in retail stores
Authors: Joy Onma Enyejo  , Omotoyosi Qazeem Obani  , Olusegun Afolabi  , Emmanuel Igba  , Akan Ime Ibokette
Published: July 2024

This review paper explores the impact of Augmented Reality (AR) and Virtual Reality (VR) technologies on customer engagement and purchasing behavior in retail settings. As immersive technologies continue to evolve, AR and VR are increasingly employed to enhance the shopping experience, offering interactive and personalized engagements that traditional retail cannot match. Through a comprehensive analysis of recent literature, the paper highlights how AR applications, such as virtual try-ons and interactive product displays, significantly enhance customer engagement by providing novel and enriched shopping experiences. Similarly, VR facilitates virtual store visits and immersive product interactions, leading to higher levels of customer satisfaction and brand loyalty. The paper discusses key metrics for evaluating engagement and purchase behavior changes, including increased dwell time, higher conversion rates, and enhanced customer satisfaction. Additionally, the review identifies challenges, such as technological integration and user adaptation, which may impede the full potential of AR and VR in retail. The findings underscore the transformative potential of AR and VR in reshaping the retail landscape by bridging the gap between digital and physical shopping environments, thus driving more informed purchasing decisions and fostering deeper customer connections. Future research directions are suggested to address the limitations and further investigate the long-term impacts of these technologies on consumer behavior.
Histopathological features of reversal reactions in Morbus Hansen
Authors: Riski Bagus Suhendra  , Diah Prabawati Retnani  , Anggun Putri Yuniaswan
Published: July 2024

The reversal reaction on Morbus Hansen is a type IV hypersensitivity reaction to M. leprae antigens. The clinical symptoms of a reversal reaction are that some or all of the existing lesions become more numerous and active in a short time. Hypopigmented lesions become more erythematous, erythematous lesions become increasingly erythematous, macular lesions become infiltrating, and old lesions increase in size. The histopathological feature of the reversal reaction showing dermal edema, stretching of the granulomas followed by loss of the well form granuloma arrangement, and predominance of lymphocytes are described as the hallmarks of a reversal reaction. Several additional characteristics were obtained in the form of an increase in the number of Langhans giant cells, as well as pyknosis/shrinkage of the lymphocyte nucleus. Although not a diagnostic criterion for a reversal reaction, histopathological examination of a lesion biopsy is needed to differentiate a reversal reaction in Morbus Hansen from other differential diagnoses.
The role of pharmacological interventions in managing hyperlipidemia: A closer look at different drugs
Authors: Arundhati Kashyap  , Deeparani Urolagin  , Ansari Aashif Raza Mohd Imtiyaz  , Samir Panda  , Deepika H L
Published: July 2024

Hyperlipidemia is a medical condition characterized by an increase in plasma lipids, including triglycerides, cholesterol, cholesterol esters, phospholipids, and plasma lipoproteins, which is a leading risk factor for cardiovascular diseases. The pathophysiology of hyperlipidemia is influenced by endothelial damage to blood vessels, leading to a loss of nitric oxide, increased inflammation, and lipid accumulation in the deepest layer of the endothelial wall. Lipid-lowering drugs like statins can reduce LDL levels by 25-60%, but they have negative impacts on clinical outcomes. Lipoprotein metabolism involves various enzymes, and atherosclerosis accumulates fat, cholesterol, and calcium in artery linings, creating fibrous plaques that reduce blood flow and oxygen supply, leading to heart damage and death. Lipoprotein metabolism involves various enzymes, including lipoprotein lipase (LPL), hepatic lipase (HL), lecithin cholesterol acyl transferase (LCAT), cholesterol ester transfer protein (CETP), microsomal triglyceride protein (MTP), and acyl Co-A transferase (ACAT). Atherosclerosis accumulates fat, cholesterol, and calcium in artery linings, creating fibrous plaques. This leads to reduced blood flow and oxygen supply, causing heart damage and death. Reducing LDL and total cholesterol can significantly lower the incidence of strokes. Reducing LDL and total cholesterol can significantly lower the incidence of strokes. Traditional antihyperlipidemic medicines have negative effects, and herbal treatments like onion, garlic, guggul, and Asparagus racemosus have been shown to have anti-diabetic and antihyperlipidemic properties.
Spontaneous Acute subdural hematoma for Hemophilia (A) patient: Case report
Authors: Yahya Farah  , Rayhane HAMDAOUI  , Mohammed ElKorno  , Mustapha HEMAMA  , Nizare EL FATEMI  , Moulay Rachid EL MAAQILI
Published: July 2024

Spontaneous Acute subdural hematoma for Hemophilia patients with symptomatic its very rare condition and very difficult for decision making and surgical intervention, in the literature most of cases managed the conservative or delaying intervention. In our report presenting symptomatic and specially had allergic with Fresh frozen Plasm which it makes difficult to surgical intervention , although this condition we successful operated and managed continuous infusion of the Factor VIII with multidiscipline approach.
Effects of the integrated use of organic and inorganic phosphorus sources in micro-doses on the yield and profitability of cowpea (Vigna unguiculata L. Walp) Cultivation
Authors: ABDOUL-KARIM Toudou Daouda  , SANOUSSI Atta  , YACOUBOU Bakasso
Published: July 2024

An experiment was conducted in the field to evaluate the effect of phosphorus fertilization in microdose using organic and mineral fertilizers on the yield and profitability of cowpea cultivation. To achieve this, a balanced application of NPK and granular compost was provided to supply the same amount of phosphorus to the cowpea. Three treatments were compared in a split-plot design with three replications, where the treatments were in large plots and the cowpea varieties, numbering four (4), were in small plots. The three treatments are as follows: (i) T0 control treatment without fertilizer application, (ii) T1 application of two grams of NPK per hole, and (iii) T2 application of 9.375 grams of granular compost per hole. The results show a significant difference in yield parameters between treatments (pod yield, grain yield, and straw yield). The mean comparison test revealed that the control treatment and NPK are quite similar for these parameters. Thus, with compost, an increase of 69.17% in grain yield, 55.47% in pod yield, and 41.67% in straw yield was noted compared to the control. The VCR (value-cost ratio) and gross income were significantly improved by compost. The application of organic or mineral fertilizers for cowpea cultivation is profitable due to relatively high VCRs: 3.34 for NPK and 6.79 for compost. Therefore, the use of compost for cowpea cultivation proves to be economically more profitable, as it yields higher returns.
Effects of combined methanol extracts of Nauclea latifolia and Voacanga africana leaves on some biochemical indices of alloxan-induced diabetes in albino rats
Authors: Joel OM  , Omodamiro OD  , Omeh YN  , Omodamiro RM  , Joel MC  , Anyaoha EO
Published: July 2024

Diabetes mellitus is a rampant global epidemy of multifactorial aetiology and risk factors. This present study was aimed at investigating the effects of combined methanol extracts of the leaves of N. latifolia and V. africana on some biochemical indices of alloxan-induced diabetes in albino rats. The rats were divided into eight groups of five rats each with group 1 as normal control, group 2 to 8 as treated diabetic control (2.0 mg/kg b.w. of glibenclamide), untreated diabetic control, 500mg/kg body weight. N.L., 500 mg/kg body weight V.A., 250 N.L.: 250 V.A., 375 N.L.:125 V.A and 125 N.L.:375 V.A respectively. The administration of the extracts was by oral (gavage) and the treatment lasted for 21 days. After 21 days, the rats were fasted overnight and sacrificed by cervical dislocation to get blood serum. All the analyses were done using standard analytical methods. The combined extracts exhibited antihyperglycaemic effect especially the 500 mg/kg b.w.N.L. and 375 NL and 125 V.A. The results disclosed that the rats of the normal control, treated diabetic control and the group administered with the 375 N.L.:125 V.A. significantly (p<0.05) increased the body weight of the rats. There was significant decrease (p <0.05) in the concentration of MDA in the rats of the treated diabetic control group and test groups when compared with rats of the untreated diabetic control. There was increase in catalase and GPx concentrations in the rats of the test groups when compared to rats of untreated diabetic control. The study also disclosed significant (p < 0.05) reduction in LDL-c, TC, TG and VDL-c, with an increase HDL-c. This study unveiled that the dose ratios of 375 N.L.:125 V.A, 500 mg/kg b.w. N.L and 250 N.L.:250 V.A efficiently reduced the blood glucose concentration and had better effect on the biochemical indices and therefore may be useful in the treatment of diabetes and diabetes-related complications.
Identification and biological control of bacterial leaf spot disease of cucurbits
Authors: M. E. Khan Chowdhury  , Md. Enamul Haque  , Mehrun Nesa  , Biswanath Sikdar  , Md. Faruk Hasan
Published: July 2024

Objective: The present study was conducted for isolation and detection of the phyto-pathogen responsible for bacterial leaf spot disease of cucurbits as well as evaluation of its biological control techniques. Methods: The pathogen of the disease was isolated from infected leaf of bitter gourd and cultured on Luria-Bertani (LB) growth medium. The morphological tests and biochemical tests revealed the isolated bacteria as gram negative. Furthermore, advanced molecular technique was applied to facilitate proper detection of the isolated bacteria. The PCR of the bacterial genomic DNA using specific primers generated clear band of approximately 1450 bp in gel electrophoresis. Results: In gram staining test, the bacterial strain was found to be rod shaped and pinkish in color and Gram-negative. All the biochemical test showed positive without mannitol salt agar. The nucleotide sequencing of 16S rDNA gene of the bacterial isolate showed 86.02% similarities with the original sequence of Xanthomonas cucurbitae. In antibiotic sensitivity assay, the antibiotic cefixime showed highest 28.0±0.7 mm diameter of inhibition zone against the tested bacteria. The highest antibacterial activity was 8.0±0.5 mm zone of inhibition by of Allium sativum. Conclusion: The present findings may be benevolent for the detection, characterization and development of biological control techniques to prevent the leaf spot disease of cucurbits crops in Bangladesh. It may help to find out the specific signaling pathway techniques for plant microbes relationship for disease formation in future.
Caries risk assessment on special needs children in Gianyar, Bali, Indonesia
Authors: Mia Ayustina Prasetya  , Luh Wayan Ayu Rahaswanti  , Putu Ika Anggaraeni  , Putu Masayu Angie Puspayanthi
Published: July 2024

Introduction: The prevalence of dental caries in Indonesia is considerably high and there is no significant improvement about that condition. Intensive care related with caries needs to be caried out, especially for special needs children. Those children have limited or even no ability to take care of their oral health and it will increase caries prevalence among them. The aim of this study is to investigate caries risk among special needs children in Gianyar, Bali, Indonesia. Methods: This is a descriptive cross sectional study which conducted on 101 pairs special needs children and their parents in Gianyar regency of Bali, Indonesia. The data was collected through questionnaire interview while intraoral assessment was done through direct intra oral examination of the special needs children. The questionnaire was an adaptation of CAMBRA Caries Risk Assessment and had gone through a validity test using Pearson Product Moment Test and a reliability test using Cronbach Alpha Test. Results: The result shows that 72.3% children are in high-risk category, 10.9% children are in extreme risk category, 8,9% children are in moderate risk category, and only 7.9% children are in low-risk category. Conclusion: The conclusion of this study is that the caries risk among special needs children in Gianyar regency of Bali, Indonesia is considerably high.
Gallium complexation for DO3A coated nanoparticles: a comprehensive study
Authors: Mudathir Ahmed Hamid  , Mohammed Ibrahim Mohammed Omer  , Fawzia E.M. Elbashir  , Neazar Essam Bagdadi  , Magd Ahmed Almalky
Published: July 2024

This review provides a comprehensive review of the synthesis and utilization of DO3A-functionalized NPs (Particularly for MRI and PET/CT analysis). The main focus of the study is the formation of a complex of gallium with NPs coated with DO3A, as well as showing the possibility of improving contrast agents and creating new gallium-based nanomaterials for medical use. The synthesis process studies parameters like pH, temperature, and the effect of substitution of the ligand using various chemical analysis techniques to determine the physicochemical properties of these nano-scale particles. This implies that gallium-loaded NPs have the potential to enhance the fight against infectious diseases, as proved by the NPs' vital role in antimicrobial therapies for PET imaging. Research with animals has shown significant biodistribution to the organs and tissues of interest, which have helped enhance the imaging features of MRI and PET/CT scans. Likewise, the findings on biocompatibility and toxicity point to possible clinical application of these nanoparticles. As for future research directions, the synthesis of other new derivatives of Gd-DO3A complexes containing lipophilic monoamides and the examination of ionization's influence on encapsulation efficiency have been mentioned. This review stresses the promising use of DO3A-coated nanoparticles for nanomedicine as therapeutic agents or imaging probes.
Enhancing stock market prediction accuracy with recurrent deep learning models: A case study on the CAC40 index
Authors: Arash Tashakkori  , Niloufar Erfanibehrouz  , Shahin Mirshekari  , Abolfazl Sodagartojgi  , Vatsal Gupta
Published: July 2024

This paper explores the application of Recurrent Neural Networks (RNNs) and Long Short-Term Memory (LSTM) networks for stock price prediction over a 10-day horizon. The study aims to compare the predictive performance of these two deep learning architectures within the context of financial forecasting. Utilizing historical stock data from the CAC40 dataset, which represents a capitalization-weighted measure of the 40 most significant stocks on the Euronext Paris, we train and evaluate RNN and LSTM models to forecast future stock prices. Our results demonstrate the superior performance of LSTM networks in capturing the intricate temporal dependencies inherent in stock price data. Compared to standard RNNs, LSTM models exhibit higher accuracy and provide more reliable forecasts over the 10-day prediction period. The specialized memory cells and gating mechanisms in LSTM networks enable them to effectively identify both short-term changes and long-term patterns in stock prices, thus outperforming traditional RNN architectures. This enhanced ability to model the complex dynamics of stock market data underscores the potential of LSTM networks to improve investment decision-making, risk management, and the overall efficiency of financial markets. The insights gained from this study contribute to the growing body of knowledge on the application of deep learning in finance and investment, offering valuable guidance for practitioners and researchers seeking to harness the power of advanced algorithms for stock market prediction and optimization.
Sentiment analysis of passenger feedback on U.S. airlines using machine learning classification methods
Authors: Md Nurul Raihen  , Sultana Akter
Published: July 2024

Twitter, a platform for micro-blogging, has contained as a novel information architecture. Everyday People worldwide publish about 200 million status messages, known as tweets. Twitter users express their opinions by posting concise text messages. Twitter data is useful for sentiment analysis and consumer feedback tweets. This study employed multi-class sentiment analysis to analyze tweets from 6 major US airlines (American, United, US Airways, Southwest, Delta and Virgin America). Airlines are essential for travel, and this study has helped people choose the best ones. Classification model with the lowest error rate could help airline companies improve their business by figuring out why information is being misclassified. This analysis of airline evaluations can help us identify good airlines and apply this model to our own journeys. This helps the airline identify its weaknesses so they can improve them. A technique of natural language processing (NLP) known as sentiment analysis (or opinion mining) classifies the tone of data as positive, negative, or neutral. The analysis was conducted with seven distinct classification strategies: Linear Discriminant Analysis, Quadratic Discriminant Analysis, Decision Tree, Random Forest, K-Nearest Neighbors, Gradient Boosting, and AdaBoost to utilize the split validation (80% as train data set, 20% as test data set) and 10 folds cross validation process. The suggested model demonstrates superior accuracy and efficiency compared to all others, achieving an accuracy score of 90.13% for the Random Forest with 10 folds cross validation approach. The project aims to utilize machine learning techniques to estimate the reasons for misclassified information since the lowest error rate means the airline sentiment provides less wrong prediction.
Analysis of economic growth and poverty levels in Indonesia based on digitalization and sharia banking financial inclusion
Authors: Yudha Praditya Kartiwa  , Lia Nazliana Nasution  , Bakhtiar Efendi  , Andria Zulfa  , Rusiadi
Published: July 2024

This research aims to analyze Indonesia's economic growth based on digitalization and Sharia banking financial inclusion. Using secondary data for the period 2014 to 2022 per quarter and the Seemingly Unrelated Regression (SUR) method, to find out which variables most influence economic growth and poverty levels in Indonesia. The results found that Sharia banking financial inclusion through the variable amount of financing, growth in funding to the private sector, and the value of sukuk ownership contributed to an increase in Indonesia's economic growth. Furthermore, both financial digitalization and financial inclusion in Sharia banking through the variables of several Sharia ATMs, total assets, amount of financing, and value of sukuk ownership can reduce poverty levels in Indonesia.
A review on multifarious medicinal potential of green synthesized silver nanoparticles
Authors: Sudakshina Trivedi  , Amrita Srivastava  , Neha Agarwal  , Pradeep Kumar Pandey  , Vijendra Singh Solanki
Published: July 2024

Momentous advancement in nanotechnology has greatly participated in bringing transformations in various challenges of society like energy production, information technology, health and environment. Out of all the challenges society is currently facing, health is the major issue. Cancer, Bacterial, Fungal and other numerous diseases are there which we need to encounter with the best possible methods. Nanoparticles owing to their better size to area ratio act as good drug delivery agents. Synthesis of nanoparticles (NPs) has already travelled a long pathway and researchers are looking for green synthesis of NPs which is non-toxic and non-hazardous pathway of NPs synthesis. Green synthesis of NPs can be performed using bacteria, fungi, algae, virus, plant extracts etc. Green synthesis is preferable because of its cost-effectiveness, energy-efficient nature, bio-compatibility and being therapeutically significant. Biological media tend to have antioxidant properties preferably plant resources which when incorporated with metal, transport same property to such nanoparticles synthesized. Since ancient times, it has been read and well-researched that silver accounts various health benefits. Therefore, silver NPs (AgNPs) are looked upon for their novel use in therapies and treatment against numerous diseases as anticancer, anti-fungal, antibacterial. This review commentates on therapeutic activity of green synthesized AgNPs, their mode of action, and potential medicinal use against many diseases as well as their antioxidant potential.
Learning from the past: Essential knowledge and vigilance for healthcare workers in future pandemics
Authors: Xu Zhanz  , Hujin Jui
Published: July 2024

This paper examines critical lessons from past pandemics and highlights essential knowledge and skills healthcare workers need to prepare for future health crises. By reviewing the Black Death, Spanish Flu, H1N1 Influenza, and COVID-19, we identify key themes such as early detection, rapid response, effective public health communication, and socio-economic impacts. We emphasize continuous education, simulation exercises, interdisciplinary collaboration, and the integration of technology in pandemic response. The roles of AI and data analytics in prediction and management, telemedicine, and innovative diagnostic tools are discussed. Ethical considerations and global cooperation are underscored to ensure equitable and effective responses. Recommendations include enhancing health security, strengthening infrastructure, and fostering a culture of vigilance. Learning from history and proactive preparation can enable healthcare workers to manage future pandemics and ensure healthcare system resilience.
A new analytical RP-HPLC method development and validation for the estimation of Nilutamide in bulk form and marketed pharmaceutical dosage form
Authors: Dhayapanthullapally Shireesha  , Rizwana Begum  , Kankala Sujatha  , Arumugam Yasodha
Published: July 2024

A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Nilutamide, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Symmetry C18 (4.6 x 150 mm, 5 µm) column using a mixture of Methanol and water (45: 55 % v/v) as the mobile phase at a flow rate of 0.8 ml/min, the detection was carried out at 260 nm. The retention time of the Nilutamide was 2.379 ± 0.02 min respectively. The method produce linear responses in the concentration range of 24-120 mg/ml of Nilutamide. The method precision for the determination of assay was below 2.0 % RSD. The method is useful in the quality control of bulk and pharmaceutical formulations. The method was validated for accuracy, precision, linearity, robustness, ruggedness and LOD & LOQ of standard solution. The developed RP-HPLC method was found to be accurate, precise, linear, and robust and was successful applied to a pharmaceutical tablet formulation for qualitative estimation of Nilutamide in Bulk form and Marketed Pharmaceutical Dosage forms.
The effectivity of edamame extract (Glycine max L. Merrill) as a heat-cured acrylic resin denture cleanser using in vitro toxicity studies
Authors: Fadhila Auliya Mahmudah  , Dewi Kristiana  , FX Ady Soesetijo
Published: July 2024

Denture cleanser that are used over a long period will produce residue that can be absorbed by the acrylic resin. The hydrophilic acrylic resin can cause denture-cleaning molecules to enter through microporosity which can be toxic to the oral tissue. Plant-based denture cleanser is commonly used one of which is edamame (Glycine Max L. Merrill) extract. Denture cleanser made from edamame extract needs to be tested for toxicity to determine the biocompatibility of the material in the oral cavity, specifically on fibroblast cells. This study aims to determine the toxicity of edamame extract as a denture cleanser for heat-cured acrylic resin, which is soaked for 4 days against BHK-21 fibroblast cells. This 4-day submersion equals 15 minutes of submersion per day for 1 year. The toxicity tests were carried out using the MTT assay method. The results of these MTT tests can be seen from the absorbance values and calculating the percentages of cell viability. The more cells that are still alive, the more intense the purple color produced. The research results showed that the acrylic resin group which was soaked in a 50% concentration of edamame extract was not toxic to fibroblast cells, because the percentage of cell viability had a value of >70%, which was 83.638%. This research concludes that 50% concentration of edamame extract as a denture cleanser for heat-cured acrylic resin is not toxic to BHK-21 fibroblast cells compared to 75% and 100% concentrations of edamame extract.
The relationship between psychiatric inpatient length of stay and suicide prevention
Authors: Consolata Uzzi  , Mujeeb Adedeji Salawu  , Nkechinyere Mary Harry  , Ibrahim Lanre Folorunsho  , Olaniyi David Ogundeji  , Adeniyi Kayode Busari  , Chidalu Ibeneme  , Nnenna Okafor
Published: July 2024

Suicide prevention remains a critical concern within mental health care, particularly for individuals with psychiatric disorders. This review examines the relationship between the length of inpatient psychiatric admission and its effectiveness in preventing suicide. The study analyzes existing literature on admission duration, in-hospital and post-discharge suicide rates, and factors influencing these outcomes such as treatment quality, patient characteristics, and post-discharge support systems. While some evidence suggests longer stays may be beneficial for certain diagnostic groups, the quality and intensity of care during admission and robust post-discharge support appear equally crucial. The review highlights the importance of individualized care plans, comprehensive suicide prevention programs, and strong transitional support. It also discusses international perspectives, ethical considerations, and special populations. The paper concludes that an effective approach to suicide prevention should focus on tailored admission lengths, high-quality care, and seamless transitions to community support, rather than solely on extending lengths of stay.
Comparison of Coren mix design with other international mix (ACI and DoE) design methods
Authors: Peter Dayo Fakoyede  , Oparinde Abdulsalam Olamilekan  , Adeleke Olaniyi Benjamin  , Ewemade Cornelius Enabulele  , Nzemeka Ogechukwu Israel  , Grace Agbons Aruya  , Jimoh Bode Jacob  , Chibuike Godswill Nzeanorue  , Habeeb Yusuf Akanji  , Ikudehinbu Temitope
Published: July 2024

Because of its quality, which allows for veracities, Today, concrete is the most frequently utilized civil engineering material. Concrete has a low tensile strength and a high compressive strength. Even though Nigeria is Africa's giant, it has been discovered that its local contractor does not have a well-used standard mix procedure. Local Nigerian contractors have relied on an international mix. COREN recently established a mix design. It is critical that we determine whether this design process will be suitable for usage by local contractors. To assess the effectiveness of the published local mix against defined international standards, a complete experimental analysis of the COREN mix design with ACI and DoE was used in this study. With a target compressive strength of 30N/mm2, three concrete mix designs with 0.48 and 0.50 water/cement ratios were used, and this mix was subjected to compressive tests, split tensile tests, and three-point bending. With respect to all the test conducted and analyzed, this attests to the level of significance of COREN i.e. For 28days mix with 0.48w/c, compressive strength with COREN gave 32N/mm2 against 31N/mm2 and 30N/mm2 for ACI and DoE mix, respectively. Splitting tensile strength of 2.7 N/mm2 was achieved with COREN mix against 2.8N/mm2 and 2.7N/mm2 from ACI and DoE, respectively. Likewise, results of flexural strength are 4.7N/mm2, 5.3N/mm2 and 5.1N/mm2 for COREN, ACI and DoE, respectively. For 28days mix with 0.50w/c, compressive strength with COREN gave 29N/mm2 against 30N/mm2 for ACI and DoE mix, respectively. Splitting tensile strength of 2.5N/mm2 was achieved with COREN mix against 2.4N/mm2 and 2.8N/mm2 from ACI and DoE, respectively. Likewise, results of flexural strength are 5.1N/mm2, 4.7N/mm2 and 5.6N/mm2 for COREN, ACI and DoE, respectively.
Effect of inhalation therapy on oral health in patients with chronic airway disease
Authors: Putu Mariati Kaman Dewi  , Made Agustya Darma Putra Wesnawa
Published: July 2024

The primary treatment for both chronic obstructive pulmonary disease (COPD) and asthma is inhalation therapy. When utilized over an extended period of time, inhalation treatment serves as both a controller and a relief therapy. Oral adverse effects can result from inhaled medications, particularly bronchodilators and corticosteroids that are deposited in the oropharyngeal region. Reduced saliva flow rate, periodontal disease, oral thrush, dental caries, and dental erosion are just a few of the side effects and difficulties associated with using inhaler therapy that are frequently discovered in the oral region. This problem may arise from improper inhaler use, concomitant diseases and conditions of the patient, inadequate education, and inadequate assessment of oral health during inhalation medication. In order to prevent side effects and complications from inhaler therapy, it is essential to comprehend the different types of inhaler drugs and the pathophysiology associated with oral health complications. This will enable clinicians to modify the components of the drug type, the type of inhaler therapy device, and the appropriate method of use based on the unique characteristics of each patient.
Youth empowerment for national development in Cameroon: The case of youths in Buea municipality, south West Region
Authors: Foncha Samuel Ngouafo Tafuh  , Budi Puspo Priyadi
Published: July 2024

Youth empowerment remains a major issue in Cameroon and the world at large. This study sought to establish the link between youth empowerment and National Development, examine the activities of the government in the process of empowering youth as well as asses the challenges faced in empowering youths in Buea municipality, South West Region of Cameroon. A cross-sectional descriptive design was used. Random sampling procedure was used to select the youths. The sample size comprised 60 respondents. A 5-point Likert scale was, where variables were categorized as follows: strongly agree, agree, neutral, disagree, and strongly disagree. Data were presented as means of each group of charts and graphs. The results revealed that there were strategies used by the government to empower youths in the municipality with policies that emerged from the study such as the Cameroon national youth policy (2006), Special youth triennial plan, Growth and Empowerment Strategy Paper (GESP 2010) even thou they were not that adequate enough. Conclusion given was that such as financial literacy training should be open for all youths, public partnerships should be fostered between the government, development partners, non-governmental organizations, financial institutions and other relevant financial institutions to help youths to access information and capital were then given to ensure and promote adequate youth empowerment.
Quantum AI for cybersecurity in financial supply chains: Enhancing cryptography using random security generators
Authors: Muhammed Azeez  , Uyiosa Osarumen Ugiagbe  , Ibiso Albert-Sogules  , Samuel Olawore  , Victor Hammed  , Emmanuel Odeyemi  , Funmilayo Stacey Obielu
Published: July 2024

Securing the financial supply chains of the United States against sophisticated cyber threats is crucial in the digital age. This research integrates Quantum Random Number Generators (QRNGs) and Artificial Intelligence (AI) to enhance cybersecurity in financial supply chains. QRNGs leverage quantum mechanics to generate truly random numbers, essential for creating secure cryptographic keys, addressing the vulnerabilities of traditional deterministic RNGs. Our results demonstrate the superior performance of the QRNG-based system compared to classical RNG systems. The QRNG showed high entropy and unpredictability, passing NIST SP800-22 and Diehard tests with significantly higher rates. The AI component achieved high precision and recall in detecting cyber threats, enhancing the system's real-time security capabilities. The combined QRNG and AI system exhibited faster encryption and decryption speeds, lower latency, and higher resistance to predictive, quantum, and brute-force attacks. This research underscores the critical importance of adopting QRNGs and AI to secure financial supply chains. The integrated system offers robust cryptographic protection and real-time threat detection, providing a comprehensive solution to mitigate cyber threats. These findings highlight the potential of QRNG and AI technologies to revolutionize cybersecurity in the financial sector, ensuring the integrity and confidentiality of financial transactions and protecting critical financial infrastructure.
Nutraceuticals: An alternative to pharmaceuticals
Authors: Babita H. More  , Pratiksha S. Bhat  , Mansi R. Singh  , Rupali R. Tasgaonkar
Published: July 2024

The study is aimed to highlights the different aspects of nutraceuticals including market trends, difficulties, and the processing methods used to harness natural resources. A very broad "nutraceutical" rise has been caused by the nutraceuticals' reach for healthcare management of chronic disorders. The majority of settings had a negligible impact on inadequate eating and lifestyle choices. Research on nutraceuticals is very important and reasonably priced. The healthcare and pharmaceutical industries are facing difficulties as a result of its financial system. It has been found that nutraceuticals contribute to the prevention of infection and cancer and have a positive effect on immune system and cardiovascular health. Based on their composition and mode of action, nutraceuticals are categorized into classes. The many kinds of nutraceuticals and their potential therapeutic effects in illness, such as their anti-inflammatory, anti-cancer, antioxidant, and anti-lipid properties, will be discussed in this review. Additionally Over the last fifty years, lifestyles have been significantly impacted by urbanization, the rate of industrialization, and rapid change. which resulted in the formation of a junk food eating habit.The ability to eat healthily is impacted by these practices, which gradually reduce the quantity and quality of nutrients consumed. Dementia, starvation, and degenerative diseases are becoming more common as a result of the population’s changed eating habits. In recent years, people’s worries about their health and ability to receive healthcare have grown. Nutraceuticals are essential for boosting immunity without compromising the body’s natural defenses. Nutraceuticals are present in active foods, designer meals, medical diets, dietary supplements, and other diet regimens that offer additional health benefits. Nutrient-rich foods help with a number of bodily functions, including the prevention and treatment of diseases. The medicinal plant offers a range of phytochemical qualities to address different medical issues.
Kasa Vyadhi: A Literature review
Authors: SAKSHI BALI  , POONAM GUPTA  , AMMANA SHARMA
Published: July 2024

Kasa is one of the pathological conditions explained in many contexts in Ayurvedic texts. Kasa may develop as an independent disease, a lakshana associative to other disease or as Upadrava of a disease. Understanding and differentiating the Kasa is most important to treat the condition effectively. In the present era Kasa is the most common disease affecting a large aged population. Kasa is one of the Pranvaha Strotodusthijanya Vyadhi. The vitiated Prana Vayu along with Udana Vayu which further gets aggravated in association with other Doshas and expelled out forcefully with a “coughing sound” like the broken bronze vessel, called as Kasa. In Ayurveda, based on the similarity in signs and symptoms, the Kasa nearest correlation is Bronchitis.
Alcohol Abuse and Emotional Intelligence among adults of Karnataka
Authors: Fathima Mariyam  , Naila P
Published: July 2024

Emotional intelligence is the capacity of a person to successfully and appropriately react to a wide range of emotional inputs that are generated from the inner self and immediate environment. The present study was an attempt to examine the impact alcohol abuse on emotional intelligence among adults situated at Karnataka State. The research instruments used were Alcohol use disorder identification test and emotion quotient test. The statistical techniques used were Spearman’s Rank correlation and Mann Whitney U Test. The findings showed a positive link between the EI dimensions. There is a significant negative association between alcohol abuse and competency dimension of EI. The studies result indicates that there was no significant association between alcohol abuse and emotional intelligence. There is a significant difference in alcohol abuse-based on the level of education but no significant difference in Emotional intelligence based on the education level.
The effect of endometriosis on the fertility of women
Authors: Roshika Fernando
Published: July 2024

Endometriosis is defined by the presence of ectopic endometrial tissue outside the uterus, frequently located on pelvic organs such as the fallopian tubes and ovaries, and occasionally beyond the pelvic region. This condition manifests as dysmenorrhea, chronic pelvic pain, dyspareunia, and subfertility. Despite extensive research, the etiology and pathogenesis of endometriosis remain unclear, with laparoscopy being the definitive diagnostic method. The association between endometriosis and infertility has been extensively debated. Endometriosis can impair fertility by disrupting embryo implantation, altering hormone levels, and compromising oocyte quality. This literature review aims to examine the effects of endometriosis on female fertility. The review encompasses documents from clinical trials with control groups involving 196 to 22,416 reproductive-age participants (25-42 years), and case studies published over the past thirty-seven years from various regions (USA, Australia, Turkey, Africa, and Europe. Reputable databases such as BMJ, NEJM, Elsevier, AJR, Medline, and PubMed were utilized, with references compiled in the bibliography. A risk-benefit analysis indicates that up to 50% of women with endometriosis experience infertility. Consensus on treatment options remains elusive. The relationship between endometriosis and infertility is supported by studies of both fertile and infertile women, animal studies, donor sperm studies, and in vitro fertilization outcomes. Diagnostic methodologies based on endometrial changes are providing insights into potential mechanisms of infertility, especially in women with milder disease. However, clinical management of endometriosis-related infertility has not shown conclusive success beyond in vitro fertilization.
Current review on nail drug delivery system and their future perspectives
Authors: Lalit Sharma  , Navneet Mehan  , Ritika Chouhan  , Suman Anjali  , Vaibhav Kumar  , KM Rekha  , Kunal Kumar  , Naman Kumar
Published: July 2024

Human nails are not only beautiful and protective, but they may also be utilized as a vehicle for drug delivery, particularly in the treatment of nail disorders such as psoriasis and onychomycosis. Even though nails develop at a somewhat moderate rate, their highly keratinized structure presents unique opportunities and challenges for medication penetration. Achieving therapeutic doses might be difficult even with topical pharmaceutical delivery, which offers advantages like non-invasiveness and customized effect. Many physical and chemical methods, such as acid etching and permeation enhancers, have been studied to improve drug penetration. It has recently been demonstrated that nail lacquers have potential for effectively delivering medication through the nails. Nail anatomy, common nail diseases, nail medication administration methods, and the advantages and disadvantages of nail lacquers are all covered in this overview. In addition, it discusses factors influencing drug diffusion through nails, draws comparisons between topical nail lacquers and oral antifungal medications, and looks at recent studies and patents on the topic. Future prospects for transungual medicine administration are promising, thanks to innovations such as photodynamic therapy and water-based lacquers. To fully realize the promise of this distribution method, more research is necessary.
Development and characterization of Decitabine Niosomes
Authors: Buruju Vennela  , Arumugam Siva Kumar  , Kassa Jyothi  , Arumugam Yasodha
Published: July 2024

The present study was focused on formulating and evaluating Decitabine containing niosomes formulation for In Vitro studies. Niosomal formulations were prepared by using different ratio of surfactant (Tween 80 and Tween 20) and cholesterol by thin film hydration method and were evaluated for In Vitro characteristics, stability studies. Span 20 containing niosomal formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that niosomal formulation was spherical in shape. Niosomes containing Tween 20 displayed higher percentage of drug release after 8 h as compared to other formulations. F-7 formulation was found to be stable at the end of the study on storage condition. The present study suggested that niosomal formulations provide sustained and prolonged delivery of drug with enhance bioavailability.