bluuebunny/crossref_metadata_2025 huggingface dataset:
Communicative Text Event and Ways of Its Attractive Construction in the Media Space (by the Material of the Russian and Korean Languages)
Authors: Orsoeva Aiuna Alexandrovna , Serebrennikova Evgeniia Fyodorovna
Published: November 2021

The study aims to reveal the role that the attractivity category plays in the construction of communicative event discourse. Linguocognitive attractivisation mechanisms are modelled, the characteristics of the main types of attractors are described using the example of the Russian and Korean languages. Scientific novelty of the study is determined by a new approach to developing ways to achieve attractivity and effectiveness in a discourse of the promoting type. It is the first time that these ways are considered as linguocognitive mechanisms that activate the addressee’s thinking on the basis of breaking the coherence of media message interpretation processes. As a result of the study, the researchers have identified the main types of cognitive mechanisms of attraction, have characterised the said types.
DESAIN SISTEM INFORMASI PERSEDIAAN BARANG STUDY KASUS MAULANA BAKERY
Authors: Putri Devita Maulina , Andarwati Mardiana , Laparsa Bony
Published: November 2021

Maulana bakery is a business entity engaged in making bread, cakes, tarts and various other snacks. The problem that occurs in this home industry is located in the current system for processing data in and out of goods, how to record it through a ledger, there is no data processing that uses a more effective database system, so that sometimes it has difficulty in calculation existing goods. The purpose of this study is to create a Goods Inventory Information System that can manage and manage incoming goods, exiting goods, stock items, ordering transactions using the Waterfall method by using a website for easier program operations. Whereas for structure modeling using Data Flow Diagrams (DFD). The end result of this Information System can manage data incoming goods, data goods out, stock of goods and ordering online.
Examination of prospective teachers' educational beliefs and attitudes towards educational history
Authors:   Department of Educational Sciences, Faculty of Education, Mehmet Akif Ersoy University, Burdur, Turkey, Aydin Rafet
Published: November 2021

The aim of this research is to reveal the educational beliefs of prospective teachers and their attitudes towards the History of Education course and the relationship between them. This research aimed to determine the opinions of prospective teachers about their future profession and to make suggestions about teacher training. The research was designed in the survey model and the relational survey model was used to determine the relationship between the variables. The sample of the study consisted of a total of 453 teacher candidates, 90 of whom were male and 363 were female. The data of the research were collected by using the "Educational Beliefs Scale" and "Attitude Scale Towards Turkish Education History Course". The data were analyzed with computer package programs. In line with the educational beliefs scale used in the research, it was revealed that the educational beliefs of the teacher candidates were 'Existentialism', 'Progressivism', 'Perennialism', 'Reconstructionism' and 'Essentialism', respectively. According to the data obtained from the scale of attitude towards education history, it was concluded that prospective teachers’ attitudes towards education history are high. Finally, it was concluded that there is a moderate, positive, and significant relationship between the educational beliefs of the prospective teachers and their attitudes towards Education History.
Examining Moral Foundations Theory through Immigration Attitudes
Authors: Nath Leda , Pedriana Nicholas , Gifford Christopher , McAuley James W. , Fülöp Marta
Published: November 2021

Moral foundations theory (MFT) explains how political and cultural attitudes are shaped significantly by people’s moral intuitions; gut-level judgments about proper human behavior and social relationships. We examine the theory through the topic of immigration attitudes. Social scientists of various stripes have built a comprehensive research program studying public attitudes towards immigrants and immigration policy. Immigration is currently among the most contentious political issues in the United States and Europe—evidenced in part by the election of Donald Trump, the UK’s Brexit vote, and the recent rise of nationalist parties on the continent. Drawing on MFT and using one politically diverse sample and one liberal-leaning sample, we conducted two experiments respectively, to test whether effects of political orientation on US immigration attitudes may be moderated by alternative moral framing of pro-immigration appeals. Data support hypotheses, and is consistent with theoretical claims about moral diversity and political attitudes generally. Also, results shed new light on how shifts in immigration attitudes, that is whether one entrenches further into an original position or is persuaded into a new attitude, depend on one’s place on the political spectrum. Keywords: moral foundations theory, moral foundations, immigration, attitudes, moral intuition, experiment
Differential expression of transformer 2 alpha homolog in cancers of the breast.
Authors: Mamoor Shahan
Published: November 2021

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding transformer 2 alpha homolog, TRA2A, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TRA2A was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TRA2A mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TRA2A in primary tumors of the breast was correlated with overall survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. TRA2A may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Zakat Dalam Perspektif Ekonomi Islam
Authors: Masni
Published: November 2021

Tulisan ini bertujuan untuk mendeskrptifkan zakat dalam prespektif ekonomi islam dengan menggunakan studi pustaka. Bahwa zakat dalam prespektif ekonomi islam mempunyai potensi yang signifikan, maka zakat perlu perhatian lebih dari pemerintah untuk kepentingan kesejahteraan masyarakyat. Akhirnya zakat bisa menjadi solusi alternatif bagi kesejahteraan masyarakat dan menjadi sumber devisa Negara. Sehingga zakat tidak hanya memiliki nilai keaagamaan tetapi juga memiliki nilai ekonomi yang signifikan.
PARTISIPASI MASYARAKAT DALAM PELAKSANAAN PEMILIHAN UMUM
Authors: Mbatu Anita Laki
Published: November 2021

. Salah satu peranan masyarakat dalam Negara demokrasi adalah partisipasi masyarakat dalam politik dalam hal ini pemilihan umum. Masyarakat memiliki peran yang sangat kuat dalam proses penentuan eksekutif dan legislatif baik dipemerintah pusat maupun daerah. Oleh karena itu perlu pendidikan politik yang harus diketahui oleh masyarakat agar pada saat pelaksaan pesta demokrasi tidak asal pilih dan hanya ikut-ikutan saja. Pendidikan politik yang baik akan menciptakan masyarakat yang cerdas sehingga mereka tidak akan salah pilih dalam memilih pemimpin atau wakil mereka.
Mempererat Sikap Toleransi Antar Umat Manusia
Authors: Ramadhani Firda Puspa Ringga
Published: November 2021

Toleransi adalah suatu sikap yang saling menghargai dan menghormati antar individu atau kelompok di dalam masyarakat meskipun terdapat perbedaan di dalamnya, baik itu perbedaan pendapat, pandangan, agama, ras, budaya, dan perbedaan lainnya. Pendapat lain mengatakan arti toleransi adalah kemampuan atau kemauan seseorang untuk bersikap sabar dan menahan diri terhadap sesuatu, khususnya terhadap keberadaan opini atau perilaku orang lain yang mungkin tidak disetujui. Secara etimologis, istilah “toleransi” berasal dari bahasa Latin “Tolerare” yang artinya menahan diri, sabar, atau membiarkan sesuatu yang terjadi. Sehingga pengertian toleransi dapat didefinisikan sebagai perilaku yang saling menghormati antar sesama manusia sesuai dengan aturan dan norma yang berlaku di masyarakat.
Pelayanan Kesehatan sebagai Bentuk Tanggung Jawab Negara Hukum yang Berdemokrasi
Authors: Ananda Sheren Mega Fitri
Published: November 2021

Sebagai negara yang mempunyai jumlah penduduk yang besar, kesehatan adalah salah satu unsur utama dalam setiap kehidupan seseorang, kesehatan merupakan pelayanan publik yang bersifat mutlak dan erat kaitannya dengan kesejahteraan masyarakat. Untuk semua pelayanan yang bersifat mutlak, negara dan aparaturnya berkewajiban untuk menyediakan layanan yang bermutu dan mudah didapatkan setiap saat. Pelayanan di bidang kesehatan merupakan salah satu bentuk pelayanan yang paling banyak dibutuhkan oleh masyarakat. Pelayanan kesehatan merupakan langkah peningkatan kesejahteraan masyarakat dan hal ini sangat penting dalam rangka meningkatkan kualitas Sumber Daya Manusia (SDM). Hak atas kesehatan merupakan salah satu hak asasi manusia dan salah satu unsur kesejahteraan yang harus diwujudkan untuk mencapai cita-cita bangsa Indonesia. Upaya pemerintah dalam memberikan pelayanan kesehatan yang baik merupakan bentuk tanggungjawab negara Indonesia sebagai negara hukum yang berdemokrasi.
Differential expression of klotho beta in cancers of the breast.
Authors: Mamoor Shahan
Published: November 2021

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding klotho beta, KLB, when comparing primary tumors of the breast to the tissue of origin, the normal breast. KLB mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of KLB in primary tumors of the breast was correlated with distant metastasis-free survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. KLB may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Pentingnya Penanaman nilai Persatuan dan Kesatuan di Lingkungan Masyarakat
Authors: Qadariah Musdalifah
Published: November 2021

Indonesia merupakan sebuah negara kepulauan yang terdiri dari beberapa wilayah dan berbatasan langsung dengan beberapa negara luar, yang secara langsung membawa dampak bagi perkembangan negara Indonesia terutama perkembangan budaya. Meskipun banyak budaya luar yang masuk ke Indonesia, namun jangan sampai hal tersebut membuat perpecahan, kesatuan dan persatuan harus tetap terjalin. Kesatuan dan persatuan suatu bangsa adalah hal yang patut diperjuangkan dengan gigih terutama di Indonesia mengingat keadaan masyarakat Indonesia memiliki latar belakang dan tingkat kepelbagaian yang sangat tinggi berdasarkan strata ekonomi, budaya, sosial, dan sebagainya. Persatuan dan kesatuan merupakan kunci suatu negara dalam membangun suatu bangsa, tanpa adanya rasa tanggung jawab dan kesadaran dalam menjaga persatuan bangsa maka keadaan suatu negara mudah tergoyah oleh berbagai ancaman baik dari luar negeri maupun dalam negeri. Oleh sebab itu, masyarakat Indonesia harus memiliki rasa tanggung jawab dan kesadaran dalam menjaga persatuan bangsa Indonesia. Persatuan itu didorong untuk mencapai kehidupan yang bebas dalam wadah negara yang merdeka dan berdaulat. Dan timbulnya kesadaran bertanggung jawab karena manusia hidup bermasyarakat dan hidup dalam lingkungan alam. keberagaman yang ada pada bangsa ini harus menjadi sebuah kekuatan tersendiri untuk membentuk warga negara yang cinta damai dan mengutamakan kekeluargaan.
Public Conceptions of Scientific Consensus
Authors: Slater Matthew H. , Huxster Joanna K. , Scholfield Emily
Published: November 2021

Despite decades of concerted efforts to communicate to the public on important scientific issues pertaining to the environment and public health, gaps between public acceptance and the scientific consensus on these issues remain stubborn. One strategy for dealing with this shortcoming has been to focus on the existence of the scientific consensus. Recent science communication research has added support to this general idea, though the interpretation of these studies and their generalizability remains a matter of contention. In this paper, we describe results of a large qualitative interview study on different models of scientific consensus and the relationship between such models and trust of science, finding that familiarity with scientific consensus is rarer than might be expected. These results suggest that consensus messaging strategies may not be effective.
Exploring the Postcolonial Concept through the Eye of European Expansionism and Imperialism
Authors: Hamad Waleed
Published: November 2021

The Postcolonial study has become very popular—it deals with colonial issues, cultural hegemony, imperialist subjects, and subservient topics. The postcolonial analysis mainly mostly involves Africa, America, Asia, and the Middle East. The imperial forces like England and France were the prominent actors in this venture. Thus, the postcolonial began after these imperial forces had left their former colonies. The formerly colonized countries were given political independence, and they began to govern themselves. However, the postcolonial study began to gain significant attention from Edward Said’s Orientalism (1978), in which he explains how Africa, the Middle East, and Asia were established on the western Imperialist structure. Edward Said explains exclusively that Orientalism vehemently accentuates the disparity between the west, their theories, social orders, literary pieces, the orient political history, tradition, norms, ideology, religion, and destiny. It dramatically reflects how the colonized adapted the cultural identity of their colonizers. The postcolonialism has been used to remember a set of conjectures and practices—and it also explains how colonialism has become a prominent and constant record. This article explores the postcolonial study, delineates the available resources that present the idea of postcolonialism, colonialism, and the effect of the Western imperialist system on the former colonies. The article also reflects Homi Bhabha’s cultural hybridity; he explains how mimicry plays a significant role in making the colonized adopt the culture of their colonizers.
Does Schooling Affect Socioeconomic Inequalities in Educational Attainment? Evidence from a Natural Experiment in Germany
Authors: Grätz Michael
Published: November 2021

Critical theories of education but also the dynamics of skill formation model predict that the education system reproduces educational inequalities. Contrary to this hypothesis, empirical studies comparing the change in inequalities in academic performance over the summer to the change in these inequalities during the school year, have argued that schooling reduces inequalities in educational performance. The present study sheds new light on the question whether schooling affects educational inequalities by analyzing a natural experiment, which induces exogenous variation in the length of schooling, and allows us to investigate the causal, long-term effects of the length of schooling on educational inequalities. Some German states moved the school start from spring to summer in 1966/1967. These states introduced two short school years, which were each three months shorter than regular school years. We use variation in the short school years across cohorts and states to estimate the causal effects of the length of schooling on inequalities in educational attainment using two German panel surveys. Less schooling due to the short school years did not affect inequalities in educational attainment. This finding runs counter to the results from the summer learning literature but also to the predictions of the dynamics of skill formation model and critical theories of education. We conclude by discussing the implications of this finding for our understanding of inequality of educational opportunity.
Innovative marketing as an effective tool of business success
Authors:   Academy of Labour, Social Relations and Tourism, Zhuk Oksana
Published: November 2021

Theoretical principles and mechanisms of innovative marketing development substantiated and covered taking into account the best European practices and national characteristics. The research is uses dialectical methods of cognition of processes and phenomena, uses a monographic method, which analyzes the evolution of scientific achievements of Ukrainian and foreign scientists on the development of innovative marketing, an empirical method of comprehensive assessment of the current state of innovation as an effective tool for business success, comparative analysis of diversity types of innovations, which creates opportunities and preconditions for their more active use by enterprises of different spheres of activity and contributes to the success of business, comparative analysis of the diversity of types of innovations, which creates opportunities and prerequisites for their more active use by enterprises of different fields and contributes to business success, as well as abstract-logical method, which developed theoretical generalizations and conclusions. Process of studying is development of innovative marketing in Ukraine and in some European countries, the current state of innovation is highlighted and its economic aspects are analyzed. The main results of modern transformations in innovation marketing are identified and it is determined that it is a systematic integration of the full innovation cycle: from consideration of market conditions of innovative products, their business planning, sales, promotion of innovative products, innovation and revenue generation. Innovation marketing differs from traditional marketing in that it is not related to a real product, but to innovations and evaluation of the effectiveness of their development and promotion in innovation. Along with the constant changes, it is advisable to formulate a definition of innovative marketing as a comprehensive system of enterprise aimed at analyzing and managing innovations based on marketing information and marketing tools and provides for the implementation of tasks using innovative marketing tools, which will contribute to business success.
Prospects of Ukrainian agricultural market development in the context of European integration
Authors:   Slovak University of Agriculture in Nitra, Synetska Yelyzaveta
Published: November 2021

Ukraine’s European integration is a multilevel, dynamic, and long process that has a complex, sometimes dramatic evolution and depends on many internal and external factors. Ukraine has favorable geographical, climatic, resource and other prerequisites for rural development, so it is potentially able to become a country with priority agricultural development and one of the main suppliers to world markets of environmentally friendly food products. However, today the problem of inconsistency between the level of development of the Ukrainian agricultural sector and rural areas in general at the world level and the standards of the EU countries remains unresolved. The prerequisites for Ukraine’s integration into the EU are analyzed, considering the advantages and disadvantages of this process for the country’s agricultural market. The necessity of transition to the investment and innovation model of development of this market was proved. Optimization of the development of all sectors of the agricultural market should become a significant direction for improving the management of innovative financing. The article considers the current state of development of the agri-food market in the foreign economic activity of Ukraine. The assessment of the level of competitiveness of agricultural products is summarized. Factors influencing the improvement of competitive positions of agricultural products in the domestic and foreign markets are proposed. Global trends indicate that Ukraine can gain a lasting push for development and even become a world leader, becoming a breadwinner for almost the whole world. The adoption of EU norms and standards in Ukraine, together with duty-free trade, should attract investors who want to introduce the latest technologies into the country’s economy. This will help turn Ukraine’s economy into an exporter of value-added products, and exports of raw materials will be a thing of the past. These global changes would have to be accompanied by a qualitatively new steps to create conditions for the liberalization of markets. This should also apply to markets for agricultural products and food products. In this way, we can expect success only if we increase the competitiveness of agricultural products. And this, in turn, can only be realized in conditions of innovative development.
A Rare Case of Giant Ovarian Serous Cystadenoma presenting as Psuedo-Meigs Syndrome
Authors: Ronald Gomes Richmond
Published: November 2021

Meigs’ syndrome is a rare condition characterized by the presence of a benign fibroma of the ovary, ascites and pleural effusion. Other benign cysts of the ovary (such as struma ovarii, mucinous cystadenoma, serous cystadenoma and teratomas), leiomyoma of the uterus, and secondary metastatic tumours to ovary if associated with hydro thorax and ascites are referred to as ‘Pseudo‐Meigs” syndrome. It very uncommon and diagnosis is made difficult by symptoms that usually mimic disseminated malignancy or tuberculosis. The gold standard treatment is laparotomy and, by definition of the syndrome, after tumor removal, the symptoms resolves and the patients become asymptomatic. We presented an 18 years old girl with giant ovarian serous cystadenoma with associated pseudo-meigs syndrome, successfully managed in a low resources setting.
Diagnosis and Management of Uterine Fibromyomas in the Obstetric Gynecology Department of the Regional Hospital of Labe. Guinea
Authors: Siddi Diallo Boubacar , Alpha Diallo Boubacar , Samba Camara Mamadou , Diallo Abdourahamane , Leno Daniel , Sory Balde Ibrahima , Sy Telly , Hyjazi Yolande , Keita Namory
Published: November 2021

Objectives: To calculate the frequency of uterine fibromyomas, to describe the epidemiological profile, to describe the management and to establish the prognosis of women with uterine fibromyomas in the gynaecology-obstetrics department of the Regional Hospital of Labé. Methodology: This was a retrospective descriptive study lasting three (3) years from 1 January 2017 to 31 December 2019. All patients admitted and operated on in the department for uterine fibromyomas during the study period were included. Patients who were not operated for uterine fibromyomas in the department and incomplete records were not included. Our data were collected and analysed using Epi-Info software version 7.2.2.6. Word, Excel and Power point software from Pack office 2016 were used for data entry and presentation. The study involved a continuous series of 115 anaemic pregnant women. We proceeded with an exhaustive recruitment of pregnant women according to the criteria defined above. Results: The frequency of uterine fibromyomas among gynaecological pathologies was 44.75%. The epidemiological profile was that of a 30-39% (40.87%), housewife (53.91%) and nulliparous (40%) woman. Pelvic pain was the dominant reason for consultation (75.65%) and 46.08% of patients had no particular history. Intramural or interstitial uterine fibromyomas were the most common (49.57%) and ultrasound was performed in all patients. The surgical indications were dominated by large polymyomatous uterus 37.39%, followed by haemorrhagic fibroid 26.09%. Myomectomy was performed in 75.65% of cases, exclusively via the abdominal route (100%), while hysterectomy was performed via the abdominal route in 17.39% of cases and vaginal route in 6.96%. The postoperative course was simple in 75.65% of cases and complicated in 24.35%. Complications were dominated by anaemia (13.04). The average length of stay was 6.05 days with extremes of 3 and 13 days. Conclusion: The frequency of the uterine fibromyomas is raised in the region of Labé and the hold in charge is often surgical
Women's Body Image Distress Associated with Cervical Cancer
Authors: Elzeblawy Hassan Hanan , Ramadan Soad , Masaud Hagar , Mohammed Ragaa
Published: November 2021

Background: Cervical cancer diagnosis and treatment can bring changes related to а woman's body image; which in turn can have a devastating on intimate relationships. Aim: The present study aimed to assess women's body image distress associated with cervical cancer. Methods; Design: A descriptive design was conducted. Setting: out-patient clinic in the oncology unit at Beni-Suef University hospital. Subjects: A purposive sample of 70 women. Tools: Data was collected through a structured interviewing questionnaire sheet, and body image scale. Results: The results of the study indicate that the majority (90%) of the studied women had body image distress. There is a statistically significant relationship between age and marriage age of women and their total body image scores. Conclusion: There is a statistical association between body image statuses amongst those women who were undergoing cervical cancer treatment concerning their socio-demographic characteristics. Recommendations: Implement an educational program to improve the self-body image for women with cervical cancer
Women with Cervical Cancer: Impact of an Educational Program their Knowledge
Authors: Elzeblawy Hassan Hanan , Ali Ragaa , El Salam Soad Abd , Kamal Hagar
Published: November 2021

Background: Cervical cancer occurs when the cells of the cervix grow abnormally and invade other tissues and organs of the body. Aim: study the impact of an educational program on knowledge of women with cervical cancer Methods; Design: A quasi-experimental design. Setting: out-patient clinic in the oncology unit at Beni-Suef University Hospital. Subjects: А purposive sample of 70 women. Tools: A structured interviewing questionnaire sheet, а scoring system for women’s knowledge аbout cervical cancer, and supportive educational booklet. Results: The results of the study revealed improving in women's knowledge regarding cervical cancer post-program compared to pre-one. Conclusion: The teaching program was very effective in women's knowledge improvement. Recommendations: Women's counseling activities for women regarding cervical cancer need to be popularized and facilities and decision-making aids are made available to those who need them.
Severe ovarian hyperstimulation syndrome with GnRH agonist trigger during the COVID pandemic: lessons learned from an unusual case
Authors: Schrader Evan , S Hurst Bradley , Hurley Tanner , Welch Lariena , Ying Ying , Eskew Ashley
Published: November 2021

Background: Injectable gonadotropins stimulate multi-follicular recruitment and allows retrieval of multiple oocytes for assisted reproduction. The widespread utilization of gonadotropin releasing hormone agonist (GnRHa) to induce oocyte maturation for oocyte retrieval has nearly eliminated the risk of severe ovarian hyperstimulation syndrome (OHSS), and only a few cases have been reported in the literature. The rarity of severe OHSS may lead to the mistaken conclusion that gonadotropin stimulation can be safely administered with limited monitoring, even in high-risk patients. We present an unusual case of a woman with limited monitoring due to the COVID pandemic who developed severe OHSS before GnRH agonist trigger and oocyte. Case Presentation: A 29-year-old nulliparous woman with polycystic ovarian syndrome (PCOS) initiated ovarian stimulation for oocyte retrieval. She had a robust initial response, and developed worsening abdominal pain, bloating, nausea, vomiting, and decreased appetite before retrieval. GnRH agonist was given to “trigger ovulation and retrieval scheduled due to the low reported incidence of severe OHSS. Symptoms progressed, and on the morning of retrieval, ultrasound demonstrated bilaterally enlarged ovaries >10cm and 48 oocytes were retrieved for a planned cryo-all cycle. She was hospitalized on the day of retrieval for severe OHSS and had two large-volume paracenteses. She was stable and discharged home by day 5, and symptoms markedly improved with the onset of menses. She has an ongoing pregnancy from her first frozen embryo transfer. Conclusion: We add a rare case of severe OHSS with a GnRHa trigger and cryo-all protocol with the onset of symptoms before GnRH agonist administration. Although rare, severe OHSS may still occur with a GnRHa trigger, and caution is needed when an initial robust response is identified. Here we also provide an opportunity to review the important patient risk factors for the development of OHSS and measures to reduce the risk in excessive responders.
Homeopathic Approach in the Case of Secondary Infertility and Anosmia
Authors: Alp Hayriye
Published: November 2021

A 38-year-old female patient diagnosed as secondary infertility, anosmia, myoma uteri, Hashimoto thyroiditis with the history of many unsuccessful IVF attempts regained her ability of smell, her thyroid antibody levels normalised, her basal hormones, AMH levels, ovarian follicular development and ovulation improved after 6 months of treatment with homeopathy and nutritional supports. In this case report, it is observed that many gynecological problems accompanied with infertility, anosmia and autoimmune problems like Hashimoto’s thyroiditis can be improved with a holistic approach to individual supportive therapies and homeopathy. It is hoped that this case report can be a reference for future studies in this field.
Awareness of Ultrasonography, Preconception during Pregnancy and use of Sonography by Tribal Women -Rural Community based Study
Authors: Chhabra S. , Nayar Sushila , Shishugruha Akanksha , S Malviya
Published: November 2021

Background: Ultrasonography (USG) has become part of everyday care of pregnant women in most of the countries of the globe. However like any other technology, it has potential to raise social, ethical, economic dilemmas about benefits, challenges for health providers, beneficiaries of the services. Awareness, utilization of USG by rural tribal women who live in extreme poverty with access problems is not well known. Objective: Community based study was carried out to know awareness of USG amongst rural, tribal, preconception, pregnant women and use of USG during pregnancy. Material methods: Study was conducted in tribal communities of 100 villages where community based mother child care services were initiated after having developed a health facility in one of 100 villages. Total 2400 preconception, 1040 pregnant women of 15-45 years, were interviewed in villages for knowing their awareness about USG, whether pregnant women had USG during pregnancy. Results: Of 2400 preconception women, 626 (26.08%) were not aware of sonography. Of those who knew, 694 (39.1%) said sonography helped in confirmation of pregnancy, 1080 (60.88%) said it helped in knowing fetal age and position. Of 1040 pregnant women also 271 (26.1%) were not aware of USG. Those who knew, sources of information, were Accredited Social Health Activists (ASHAs) in 208 (27%), nurse midwives in 170 (22.1%), family members in 311 (40.4%), doctors in 80 (10.4%). Only 258 (33.5%) of 769 women who knew about USG had got USG done. Of them 82 (31.8%) were told that something was wrong without any details. Conclusion: Study revealed that many rural tribal women did not even know about USG. Community health workers, ASHAs did create awareness of USG in some. Only 25% pregnant women had USG done but without knowing any details of findings.
Cystectomy of Ovarian Borderline and Malignant Tumors for Fertility Sparing: Outcome of Seventeen Cases
Authors: Wroblewski Junko , Takita Miyoko , Eto Haruka , Yamamichi Rikiko , Yoneda Tomoko , Nishi Daisuke , Matsuura Toshiaki , Maruyama Tomoyoshi , Wroblewski Greggory , Kato Seiya , Muta Ayako , Sato Shinsuke , Sanada Sakika , Nakayama Tomohiro , Okamoto Daisuke , Sakai Kunihiro
Published: November 2021

Background: Here we present a retrospective study of 17 cases in which the ovary on the affected side was spared in fertility-sparing surgery (FSS) during treatment for ovarian borderline malignant or malignant tumor. We determine that cystectomy is a suitable treatment for ovarian borderline tumors. Methods: A retrospective observation study was conducted at Saiseikai Fukuoka General Hospital in Japan between April 2009 and September 2020. Our hospital experienced 89 cases of FSS during treatment for ovarian borderline or malignant tumor. Of those, there were 17 cases in which the ovary on the affected side was spared. We examined recurrent and pregnant cases by stage, preoperative diagnosis, intraoperative pathological diagnosis, postoperative pathological diagnosis, and adjuvant therapy. Result: Of the 17, 12 cases were borderline malignant tumor, 4 were immature teratoma grade 1 (G1), and 1 case was endometrioid adenocarcinoma G1. Rapid intraoperative pathological diagnosis was conducted in 9 of the cases, and there were 6 in which surgical method was chosen based on the aforementioned results. Laparoscopic surgery was performed in 2 cases in which tumors were deemed benign via preoperative diagnosis, 2 cases of mature teratoma, and 2 in which borderline ovarian tumor was suspected. One (1) case of paraovarian cystecomy in a patient with history of multiple cesarean sections turned out to be serous borderline tumor. Postoperative treatment took place in only 1 case: endometrioid adenocarcinoma. There were 2 cases of recurrence, and 4 cases were eventually able to become pregnant naturally post-surgery. These pregnant cases included 1 in which serous borderline tumor recurred and we performed both cystectomy and lymphadenectomy, and one in which chemotherapy was performed after cyst enucleation for endometrioid adenocarcinoma G1. Conclusion: At present, there is no clear policy for FSS in cases such as stage Ib in which there are bilateral tumors. Accordingly, in the current study a radiologist was consulted for preoperative diagnosis, and surgical method was chosen with a view towards possible borderline malignancy or malignancy. In cases where fertility preservation of the affected ovary is a high priority, it is crucial to clearly explain the possibility of recurrence to the patient. We also stress the importance of detailed consultation among the surgical team during rapid intraoperal frozen section pathological examination for making the appropriate decision to ensure fertility preservation mid-surgery.
Tubal patency after Laparoscopic salpingostomy versus Methotrexate therapy in undisturbed tubal pregnancy
Authors: M. Tawfik Waleed , A. Bendary Ali , A. Elgazar Mohamed
Published: November 2021

Future fertility after ectopic pregnancy is dependent on several factors, including age, history of infertility, history of previous EP, tubal rupture, and contralateral tubal lesion. Thus, it seems reasonable to assess tubal patency following a treatment of an ectopic pregnancy in those women who are willing to have future pregnancy. Aimed to: Compare between tubal patency after methotrexate & laparoscopic salpingostomy. The study included 72 patients equally divided in number into 2 main groups. First group: (36cases) Tubal ectopic pregnancy treated by MXT therapy single or multiple doses. Single dose regimen (MTX 1.0 mg/kg or 50 mg/m2 i.m or multiple dose regimen (MTX 1.0 mg/kg i.m days (0,2,4,6). Second group: - (36 cases) Tubal ectopic pregnancy treated by laparoscopic salpingostomy. After 3 months, we used laparoscopy with administration of methylene blue (MB) as a marker to detect the tubal patency. As regard to tubal patency, of 31 cases (86.1%) from 36 cases that treated by MTX were patent and 5 cases (13.9 %) were blocked. On the other side 21 cases (58.3 %) from 36 cases that treated by laparoscopic salpingostomy were patent and 15 cases (41.7 %) were blocked). Conclusions:Methotrexate is better than laparoscopic salpingostomy in treating undisturbed tubal pregnancy.
La transmission d’informations en psycho-oncologie : des recommandations à la clinique
Authors: Favré E. , Normandin T. , Lamore K.
Published: November 2021

La transmission des informations en psychooncologie est une condition nécessaire pour permettre une prise en charge globale adaptée aux spécificités et aux besoins du patient. Nous rappellerons ici les recommandations publiées en 2012 par la Société française et francophone de psycho-oncologie afin de les mettre en perspective de deux situations cliniques. Ces dernières se centrent sur deux troubles de la personnalité dont le diagnostic, plus complexe en situation oncologique, rend la transmission des informations d’autant plus nécessaire que pour d’autres troubles psychiques plus fréquents.
Therapeutic Targets of Tumor Metabolism
Authors: Chubenko V.A.
Published: November 2021

Tumor cell metabolism has certain distinctive features such as aerobic glycolysis, utilization of alternative energy sources, increased lipid synthesis, mitochondrial dysfunction, macropinocytosis, autophagy, high levels of ROS, tumor microenvironment and hypoxia. This heterogeneity is determined by the malignant phenotype and the environmental conditions. Targeting specific metabolic pathways may be a promising treatment to increase the overall survival. This paper demonstrates the metabolic reprogramming as the potential anticancer strategy.
Education, Occupational Complexity, and Incident Dementia: A COSMIC Collaborative Cohort Study
Authors: Hyun Jinshil ,   for Cohort Studies of Memory in an International Consortium (COSMIC), Hall Charles B. , Katz Mindy J. , Derby Carol A. , Lipnicki Darren M. , Crawford John D. , Guaita Antonio , Vaccaro Roberta , Davin Annalisa , Kim Ki Woong , Han Ji Won , Bae Jong Bin , Röhr Susanne , Riedel-Heller Steffi , Ganguli Mary , Jacobsen Erin , Hughes Tiffany F. , Brodaty Henry , Kochan Nicole A. , Trollor Julian , Lobo Antonio , Santabarbara Javier , Lopez-Anton Raul , Sachdev Perminder S. , Lipton Richard B.
Published: November 2021

Background: Education and occupational complexity are main sources of mental engagement during early life and adulthood respectively, but research findings are not conclusive regarding protective effects of these factors against late-life dementia. Objective: This project aimed to examine the unique contributions of education and occupational complexity to incident dementia, and to assess the mediating effects of occupational complexity on the association between education and dementia across diverse cohorts. Method: We used data from 10,195 participants (median baseline age = 74.1, range = 58∼103), representing 9 international datasets from 6 countries over 4 continents. Using a coordinated analysis approach, the accelerated failure time model was applied to each dataset, followed by meta-analysis. In addition, causal mediation analyses were performed. Result: The meta-analytic results indicated that both education and occupational complexity were independently associated with increased dementia-free survival time, with 28%of the effect of education mediated by occupational complexity. There was evidence of threshold effects for education, with increased dementia-free survival time associated with ‘high school completion’ or ‘above high school’ compared to ‘middle school completion or below’. Conclusion: Using datasets from a wide range of geographical regions, we found that both early life education and adulthood occupational complexity were independently predictive of dementia. Education and occupational experiences occur during early life and adulthood respectively, and dementia prevention efforts could thus be made at different stages of the life course.
Patterns of Distribution of 18F-THK5351 Positron Emission Tomography in Alzheimer’s Disease Continuum
Authors: Nihashi Takashi ,   MULNIAD Study Group, Sakurai Keita , Kato Takashi , Iwata Kaori , Kimura Yasuyuki , Ikenuma Hiroshi , Yamaoka Akiko , Takeda Akinori , Arahata Yutaka , Washimi Yukihiko , Suzuki Keisuke , Bundo Masahiko , Sakurai Takashi , Okamura Nobuyuki , Yanai Kazuhiko , Ito Kengo , Nakamura Akinori
Published: November 2021

Background: Alzheimer’s disease (AD) is conceptualized as a biological continuum encompassing the preclinical (clinically asymptomatic but with evidence of AD pathology) and clinical (symptomatic) phases. Objective: Using 18F-THK5351 as a tracer that binds to both tau and monoamine oxidase B (MAO-B), we investigated the changes in 18F-THK5351 accumulation patterns in AD continuum individuals with positive amyloid PET consisting of cognitively normal individuals (CNp), amnestic mild cognitive impairment (aMCI), and AD and cognitively normal individuals (CNn) with negative amyloid PET. Methods: We studied 69 individuals (32 CNn, 11 CNp, 9 aMCI, and 17 AD) with structural magnetic resonance imaging, 11C-Pittsburgh compound-B (PIB) and 18F-THK5351 PET, and neuropsychological assessment. 18F-THK5351 accumulation was evaluated with visual analysis, voxel-based analysis and combined region of interest (ROI)-based analysis corresponding to Braak neurofibrillary tangle stage. Results: On visual analysis, 18F-THK5351 accumulation was increased with stage progression in the AD continuum. On voxel-based analysis, there was no statistical difference in 18F-THK5351 accumulation between CNp and CNn. However, a slight increase of the bilateral posterior cingulate gyrus in aMCI and definite increase of the bilateral parietal temporal association area and posterior cingulate gyrus/precuneus in AD were detected compared with CNn. On ROI-based analyses, 18F-THK5351 accumulation correlated positively with supratentorial 11C-PIB accumulation and negatively with the hippocampal volume and neuropsychological assessment. Conclusion: The AD continuum showed an increase in 18F-THK5351 with stage progression, suggesting that 18F-THK5351 has the potential to visualize the severity of tau deposition and neurodegeneration in accordance with the AD continuum.
The Importance of Being Familiar: The Role of Semantic Knowledge in the Activation of Emotions and Factual Knowledge from Music in the Semantic Variant of Primary Progressive Aphasia
Authors: Macoir Joël , Tremblay Marie-Pier , Wilson Maximiliano A. , Laforce Robert , Hudon Carol
Published: November 2021

Background: The role of semantic knowledge in emotion recognition remains poorly understood. The semantic variant of primary progressive aphasia (svPPA) is a degenerative disorder characterized by progressive loss of semantic knowledge, while other cognitive abilities remain spared, at least in the early stages of the disease. The syndrome is therefore a reliable clinical model of semantic impairment allowing for testing the propositions made in theoretical models of emotion recognition. Objective: The main goal of this study was to investigate the role of semantic memory in the recognition of basic emotions conveyed by music in individuals with svPPA. Methods: The performance of 9 individuals with svPPA was compared to that of 32 control participants in tasks designed to investigate the ability: a) to differentiate between familiar and non-familiar musical excerpts, b) to associate semantic concepts to musical excerpts, and c) to recognize basic emotions conveyed by music. Results: Results revealed that individuals with svPPA showed preserved abilities to recognize familiar musical excerpts but impaired performance on the two other tasks. Moreover, recognition of basic emotions and association of musical excerpts with semantic concepts was significantly better for familiar than non-familiar musical excerpts in participants with svPPA. Conclusion: Results of this study have important implications for theoretical models of emotion recognition and music processing. They suggest that impairment of semantic memory in svPPA affects both the activation of emotions and factual knowledge from music and that this impairment is modulated by familiarity with musical tunes.
Circulatory GSK-3β: Blood-Based Biomarker and Therapeutic Target for Alzheimer’s Disease
Authors: Kumari Shiwani , Singh Ambica , Singh Abhinay Kumar , Yadav Yudhishthir , Bajpai Swati , Kumar Pramod , Upadhyay Ashish Datt , Shekhar Shashank , Dwivedi Sadanand , Dey A.B. , Dey Sharmistha
Published: November 2021

Background: Alzheimer’s disease (AD) is the progressive brain disorder which degenerates brain cells connection and causes memory loss. Although AD is irreversible, it is not impossible to arrest or slow down the progression of the disease. However, this would only be possible if the disease is diagnosed at an early stage, and early diagnosis requires clear understanding of the pathogenesis at molecular level. Overactivity of GSK-3β and p53 accounts for tau hyperphosphorylation and the formation of amyloid-β plaques. Objective: Here, we explored GSK-3β and p53 as blood-based biomarkers for early detection of AD. Methods: The levels of GSK-3β, p53, and their phosphorylated states were measured using surface plasmon resonance and verified using western blot in serum from AD, mild cognitive impairment (MCI), and geriatric-control (GC) subjects. The neurotoxic SH-SY5Y cell line was treated with antioxidant Emblica Officinalis (EO) for rescue effect. Results: GSK-3β, p53, and their phosphorylated states were significantly over expressed (p > 0.001) in AD and MCI compared to GC and can differentiate AD and MCI from GC. The expression level of GSK-3β and p53 proteins were found to be downregulated in a dose-dependent manner after the treatment with EO in amyloid-b-induced neurotoxic cells. Conclusion: These proteins can serve as potential blood markers for the diagnosis of AD and EO can suppress their level. This work has translational value and clinical utility in the future.
A molecular protocol for Early Sex Discrimination (ESD) in Actinidia spp
Authors: De Mori G. , Testolin R. , Cipriani G.
Published: November 2021

Dioecism and an extended juvenile phase of 3–7 years in kiwifruit hinder the progress in breeding new cultivars. The identification of fruit-bearing females at an early stage of growth is crucial for breeders. Consequently, molecular markers have become a key tool for identifying female and male plants at an early stage of development. Several efforts were made to identify PCR-based sex linked markers in Actinidia; however, those markers are characterized by a highly polymorphic nature affecting the result of the screening reliability, suggesting the need of more suitable, stable markers, characterized by a consistent transferability among genotypes and species. The main goal of this work was to develop a method for the ultimate discrimination of females from male plants at an early stage of growth using sex-linked markers. We developed an Early Sex Discrimination molecular Test (ESD Test) that allows the discrimination of male and female plants using a simple PCR amplification test. We demonstrate that the test could unequivocally identify the gender of an unknown sample both in the most commercially important species A. chinensis and in further 13 Actinidia species tested with the exception of Actinidia latifolia, where markers fail in gender discrimination. Male genotypes could be easily identified and discarded reducing the cost of a breeding program.