bluuebunny/crossref_metadata_2025 huggingface dataset:
A simple and efficient method to extract polar metabolites from guar leaves (Cyamopsis tetragonoloba (L.) Taub.) for GC-MS metabolome analysis
Authors: Teplyakova S. B. , Shavarda A. L. , Shelenga T. V. , Dzyubenko E. A. , Potokina E. K.
Published: February 2019

Guar (Cyamopsis tetragonoloba (L.) Taub.) is an agricultural crop species new to Russia and is in demand by the gas, oil and food industries. Due to the progress of “omics” technologies and the marker-assisted selection, there is a huge interest in the studies that compare the metabolites of various guar varieties, employing metabolomics as a method of functional genomics. For a large-scale screening of guar germplasm from the VIR collection, it is important to choose an efficient method to extract metabolites from samples. The accuracy of the assessment of the content of metabolites in samples is crucial for distinguishing varieties within the crop, since the metabolome profiles of plants within the same species differ mainly in the quantitative ratio of metabolites, and not in their qualitative composition. In metabolome practice, two methods of extracting polar compounds are usually employed in the preparation of samples for GC-MS analysis. One of the widely used methods of sample preparation is the long-term extraction of metabolites from whole tissues with the aid of a methanol solvent. Another method of sample preparation is based on the short-term methanol extraction of metabolites from frozen and homogenized material. The advantages and disadvantages of these two methods revealed in the course of our work have prompted us to develop a new approach that avoids some difficulties in analyzing the metabolic profiles of leaves of various guar varieties. The method we suggested combines the advantages of the two above-mentioned approaches of sample preparation, namely eliminates the loss of metabolites due to centrifugation and ensures the complete destruction of all cell walls, ensuring the maximum extraction level of polar metabolites. The essence of the new method is that the leaf is rapidly frozen in liquid nitrogen with subsequent thawing in cold methanol. Thus, leaf tissues retain morphological integrity, and subsequent centrifugation, necessary for homogenization, is skipped. We have checked the effectiveness of this improved method by experiments with leaf samples of three guar genotypes. It has been shown that the amount of extracted metabolites increases more than 5-fold compared to extraction with methanol from fresh unfrozen leaf tissues and more than 2-fold compared to extraction with methanol after freezing and homogenization. Extraction of metabolites using the new method allows the GC-MS analysis of guar samples to be conducted with the least loss and high accuracy required to distinguish varieties.
Sex differences in the expression of lipid oxidation and glucose uptake genes in muscles of fasted mice
Authors: Feofanova N. A. , Yakovleva T. V. , Makarova E. N. , Bazhan N. M.
Published: February 2019

Fasting has become increasingly popular for treatment and prevention of obesity. Sex differences in the mechanisms of adaptation to fasting may contribute to choosing a therapeutic strategy for correction of metabolic disorders. Hepatokine fibroblast growth factor 21 (FGF21) is involved in the adaptation to fasting. Muscles are assumed to be the main energy-consuming tissue in the body, as muscle metabolism plays an important role in the adaptation to nutritional deficit. However, there is still little information on sex differences in muscle and FGF21 physiological response to fasting. Our aim was to find out whether there were sex differences in hormonal regulation and the expression of genes controlling glucose and lipid metabolism in skeletal muscles in response to fasting. We estimated the effect of 24-hour fasting on the expression of genes involved in lipid (Ucp3, Cpt1) and carbohydrate (Slc2a4) metabolism in muscles and evaluated changes in body weight and blood plasma levels of glucose, insulin, free fatty acids (FFA), adiponectin, and FGF21 in male and female C57BL/6J mice. None of the genes studied (Ucp3, Cpt1 and Slc2a4) showed sex-related changes at mRNA levels in control groups, but females exposed to fasting demonstrated a significant increase in the expression of all genes as compared to control. Fasting significantly decreased body weight and glucose blood plasma levels in animals of both sexes but exerted no effect on the levels of insulin or FFA. The adiponectin and FGF21 levels were increased in response to fasting, the increase in females being significant. We were first to show sex dimorphism in muscle gene expression and FGF21 blood level in response to fasting. In females, the greater increase in FGF21 and adiponectin blood levels was positively associated with the greater upregulation of lipid oxidation and glucose uptake gene expression.
The role of DNA methylation in the disorders of bone metabolism
Authors: Yalaev B. I. , Tyurin A. V. , Mirgalieva R. Y. , Khusainova R. I.
Published: February 2019

Osteoporosis is one of multifactorial diseases, it develops from interactions between the genetic component and the environment. However, the universal epigenetic markers of osteoporosis are not yet defined. Finding the risk factors will predict the risk of osteoporosis at the preclinical stage, help define the course and severity of the disease, and develop preventive measures based on them to reduce the risk of fractures. Expanding knowledge in the field of bone biology, especially in the genetics of osteoporosis and osteoimmunology, showed that osteoporosis is a disease that occurs not only due to hormonal or mechanical disorders, but also as a clinically and genetically heterogeneous disease, and there are still unknown pathogenetic links in its structure. Decreases in bone mass and matrix mineralization as well as changes in bone microarchitecture can have different pathogenetic patterns of development and, moreover, there are unknown links of the pathogenesis of osteoporosis. It is possible that DNA methylation is one of these links and a mechanism for epigenetic regulation of gene expression. Evidence exists that this mechanism alongside regulatory miRNAs and post-translational modifications makes a significant contribution to the central processes of bone remodeling; however, the results of various studies vary greatly, and, therefore, there is a need to understand the significance of the accumulated data and to make them consistent. The purpose of this review is to compile and systematize data on the role of DNA methylation in bone metabolism in normal and pathological conditions, in the formation of osteoporosis, and to assess achievements and trends in this field of research and technologies for studying DNA methylation.
The frequency of distribution of the genotypes of the IL4 polymorphism (rs 2243250) in psoriasis and psoriatic arthritis
Authors: Barilo A. A. , Smolnikova M. V. , Smirnova S. V.
Published: February 2019

Psoriasis (PS) and psoriatic arthritis (PsA) are multifactorial diseases determined by the result of complex combined interaction of genetic and environmental factors. The study of genetic polymorphism of PS and PsA will allow identification of common diagnostic criteria for the progression of pathology. The aim was to analyze the frequency of distribution of genotypes of the promoter region of the C-590T (rs2243250) gene IL4 in patients with psoriasis and psoriatic. The study included patients with psoriasis (n = 49) and psoriatic arthritis (n = 48), which, taking into account the carriage of certain genotypes, are divided into groups: 1, PS, carriers of the C/С genotype (n = 31); 2, PS, carriers of the C/T and T/T genotype (n = 18); 3, PsA, carriers of the C/С genotype (n = 30); and 4, PsA, carriers of the C/T and T/T genotype (n = 18). DNA extraction from whole venous blood was performed using a standard kit with a sorbent. Genotyping allelic variants was carried out by the method of restriction analysis of amplification products (RFLP-analysis) of specific regions of the genome. In PS carriers of the C/С IL4 (rs2243250), the value of the PASI index is statistically significantly lower relative to the carriers of the C/T and T/T genotypes. A possible association of the carriage of the C/T and T/T genotypes in PsA with nail psoriasis was noted in comparison with the C/C genotype. When studying intergroup differences, it was determined that the carriage of the C/C genotype in PsA can influence the clinical course of the psoriatic process with frequent exacerbations and involvement of more than 30 % of the hairy part in the pathological process. The carriage of the C/T and T/T genotypes in PsA may be associated with the Koebner phenomenon and the metabolic disorders in comparison with PS. Differences in the carriage of the C/C genotypes relative to C/T and T/T IL4 (rs2243250) in psoriasis and psoriatic arthritis were determined. Given the extremely low number of patient groups, the results should be considered as preliminary and require further testing on much larger samples.
Reorganisation of chromatin during erythroid differentiation
Authors: Khabarova A. A. , Ryzhkova A. S. , Battulin N. R.
Published: February 2019

A totipotent zygote has unlimited potential for differentiation into all cell types found in an adult organism. During ontogenesis proliferating and maturing cells gradually lose their differentiation potential, limiting the spectrum of possible developmental transitions to a specific cell type. Following the initiation of the developmental program cells acquire specific morphological and functional properties. Deciphering the mechanisms that coordinate shifts in gene expression revealed a critical role of three-dimensional chromatin structure in the regulation of gene activity during lineage commitment. Several levels of DNA packaging have been recently identified using chromosome conformation capture based techniques such a Hi-C. It is now clear that chromatin regions with high transcriptional activity assemble into Mb-scale compartments in the nuclear space, distinct from transcriptionally silent regions. More locally chromatin is organized into topological domains, serving as functionally insulated units with cell type – specific regulatory loop interactions. However, molecular mechanisms establishing and maintaining such 3D organization are yet to be investigated. Recent focus on studying chromatin reorganization accompanying cell cycle progression and cellular differentiation partially explained some aspects of 3D genome folding. Throughout erythropoiesis cells undergo a dramatic reorganization of the chromatin landscape leading to global nuclear condensation and transcriptional silencing, followed by nuclear extrusion at the final stage of mammalian erythropoiesis. Drastic changes of genome architecture and function accompanying erythroid differentiation seem to be an informative model for studying the ways of how genome organization and dynamic gene activity are connected. Here we summarize current views on the role of global rearrangement of 3D chromatin structure in erythroid differentiation.
A system approach to the modeling of fungal infections of the wheat leaf
Authors: Nikolaev S. V. , Zubairova U. S. , Skolotneva E. S. , Orlova E. A. , Afonnikov D. A.
Published: February 2019

Currently, studies on the mechanisms of the pathogenesis of plant diseases and their distribution in crops are intensively conducted in Russia and the world. First of all, this interest is associated with a significant effect of pathogens on the harvest. In Western Siberia, brown rust and powdery mildew are almost annually recorded in the crops of spring and winter wheat, reaching in some years up to the epiphytotic level. In this regard, methods for monitoring the condition of crops in order to predict their dynamics and plan agrotechnological events to control the state of plants in crops, including the development of fungal infection are developing. Models of fungal infections development on the wheat leaf (for example, brown rust) are used to monitor, predict and control the state of crops in order to optimize the growing process. Mathematical models allow computational experiments to make predictions about the risk dynamics of infections in different scenarios of global weather changes. Such designation of models assumes their hierarchical structure characteristic of multilevel modeling systems. This review presents models for the development of foliar fungal infections in crops, and formulates the methodological aspects of system modeling that can be used for adapting existing models and their units, and developing new models based on them. The article presents the structure of the hierarchical system for modeling the development of leafy infection, provides an overview of the units constituting the system, and discusses the issues of parametric adaptation of submodels. We demonstrated that, to date, plant growth and development models have been developed with varying degrees of detail. Currently, to develop a system for modeling the development of an infection in a crop, it is necessary to determine a large body of available experimental data and, by taking into account this data, we can put together a model as a system consisting of model modules, for which the models of basic processes have already been developed and described.
Yarı Kurak İklim Şartlarında Yetiştirilen Patates (Solanum tuberosum L.) Çeşitlerinde Dikim Zamanının Belirlenmesi
Authors: ARSLAN Hüseyin
Published: February 2019

Bu araştırmada, Siirt ili iklim koşullarında bazı patates çeşitlerinde
uygun dikim zamanının belirlenmesi amaçlanmıştır. Çalışma; Siirt Üniversitesi,
Ziraat Fakültesi, Araştırma ve Uygulama Arazisi’nde 2017-2018 yıllarında
yürütülmüş olup, araştırmada bitkisel materyal olarak Alegria, Borvina ve
Soraya patates çeşitleri kullanılmıştır. Dikim zamanları olarak ise, 5 farklı
dikim zamanı (2017 yılında 14 Şubat, 05 Mart, 27 Mart, 16 Nisan ve 04 Mayıs; 2018
yılında ise 16 Şubat, 05 Mart, 25 Mart, 16 Nisan ve 02 Mayıs) ele alınmıştır.
Araştırmada, tarla denemeleri tesadüf bloklarında bölünmüş parseller deneme
desenine göre 4 tekerrürlü olarak yürütülmüştür.  Çalışmada; dekara yumru verimi, bitki başına
yumru sayısı, bitki başına yumru ağırlığı ve ortalama yumru ağırlığı gibi bazı
tarımsal parametreler incelenmiştir. Araştırma sonuçlarına göre, patates
tarımında dikim zamanının ve çeşit seçiminin verim üzerinde çok önemli bir
etkiye sahip olduğu; incelenen parametrelerin sıcaklıklarda meydana gelen küçük
değişimlere dahi tepki gösterdiği; en yüksek verimin Mart ayı içerisinde
yapılan dikimlerden alındığı tespit edilmiştir. Araştırmada her iki yılda da en
yüksek yumru verimi (sırasıyla, 4001.38 ve 3066.13 kg da-1) Soraya
çeşidinden elde edilmiştir. Çalışma sonucunda, Siirt ili ve benzeri iklim
koşullarında patates dikimlerinin Mart ayı içerisinde yapılması gerektiği ve
“Soraya” çeşidinin rahatlıkla önerilebileceği sonucuna varılmıştır.
Physical Sanitation of the House that Influence the Incidence of ARI in Children under Five in Kalianget Timur Village
Authors: Agungnisa Adhasari
Published: February 2019

Physical sanitation of the house and parent’s behavior are the factors that could affect the incidence of ARI in children under five. The aim of this research was to analyze what factors of house physical sanitation that affect the occurrence of ARI among children under five in East Kalianget Village. This research was an observational research, with cross sectional design. The samples in this research were 60 children under fives randomly chosen through simple random sampling. Data collection was done through interview, observation, thermohygrometer, roll meter, lux meter, and EPAM 5000. Data was analyzed using chi-square and binary logistic regression analysis. The results showed that children under five’s bedroom density (p=0.241) was affecting the occurrence of ARI among children under five, meanwhile ventilation area (p=0.241), air temperature (p=0.948), humidity (p=0.830), and lighting (0.393) were not affecting the occurrence of ARI among children under five. Communities of East Kalianget Village that have unsuitable occupancy density are suggested to reset the number of their bedroom’s occupants, for example maybe a father sleeping in the living room to prevent the occurrence of ARI among children under five.
Hearing Loss And Health Complaints In Technicians Air Skadron 3 Iswahjudi Airport And Its Association With Aircraft Noise
Authors: Choirunisa Ristyna
Published: February 2019

Aviation is the most significant part of Indonesian Air Force duty. Air Force’s aircraft takes a role not only as Indonesian army agency transportation vehicle but also crucial for Indonesian air territory security protection. However the level of noises resulted from Air Force aviation operation activity such as take off of aircraft reached 130 dBA, so the operation can causes auditory and non auditory adverse effects such as communication, physiological disorder, and psycological disorder. The aim of this study  is to analyze factors induced to the hearing loss and analyze the effects of aircraft noises to technician health complaints. This research using case control approach and it was conducted by recruiting subject respondents group randomly of 20 officers includes of 10 technician as study group and 10 non technician as control group. The measurement of aircraft noise level was performed 4 times during 8 hours used Sound Level Meter. The results of aircraft noise measurement in flightline area was exceeding the threshold value of 95,56 dBA. The results of the study shows that aircraft noise significantly associated with to technician hearing loss p-value=0,026 (Spearman correlation test, p<0,05). Other factors that are associated significantly with technician hearing loss include aged p-value=0,023 (Pearson correlation test,  p<0,05). Insignificant association is showed for work period with p-value=0,038 (spearman correlation test, p<0,05). In addition, the aircraft noise is associated to health complaint as psychological disorder p-value=0,033 (simple logistic regression test, p-value <0,05). The conclusion of research is that aircraft activities affected hearing loss and technician psychological disorder.
Hygiene and Sanitation of Food Processing Center in Gudang 100 Warehouse at Tanjung Perak Sea Port of Surabaya 2018
Authors: Dakwani Tifal -
Published: February 2019

Food Processing Premise is a place for processing food raw ingredients to become ready to consume food. In order to function optimally, the premises are needed to be controlled frequently particularly in the port area where many visitors and staffs are in needs of health protection during their activities in this area.  For this purpose, the authority has been attempting to increase and maintain food and baverage quality in this area therefore it could avoid any public health menaces from food contamination and intoxication for the population. As basic health survey (RISKESDAS) in 2013 reported diseases contributed as public health threats such as diarrhea 3.5%, typhoid 2.2%, hepatitis 1.2% (Riskesdas, 2013). The study aims to analyse the hygiene and sanitation implementation of food processing center in Gudang 100 warehouse at Tanjung Perak Sea Port of Surabaya. This present study is an observational study with cross sectional design. The sample was obtained based on 2017 data and mapping of 60 food tenant premises. 5 places were observed during study period. The variables observed were including of location, building, sanitation facilities, dining room, food storage, ingredients, food, the process, serving, food stuff, and the employee. The variables were observed using the total score as enacted by Indonesian Ministry of Health regulation NO.1098/MENKES/SK/VII/2003 regarding of Hygiene and sanitation standards for food stalls and restaurant. The result of the study shows there are 2 food stalls (B and C) with score <700 while the other stalls (A, D and E) reach score >700. The conclusion of this study highlights the needs of adjusting the requirement of the hygiene and sanitation of food stalls and restaurant as well as provide regular trainings for food handlers.
Fifty percent of food restriction during gestation reduced the dendritic density of cerebrum and cerebellum of Rattus norvegicus newborn
Authors: Fauzi Anwar , Widjiati Widjiati , Joewono Hermanto T
Published: February 2019

Objectives: To analyze the influence of 50 percent food  restriction during pregnancy to the dendritic density of cerebellum and cerebellum of newborn Rattus norvegicus.Materials and Methods: Laboratory experimental study with single blind randomized post-test only control group design using animal model; pregnant Rattus norvegicus as treatment models. Subjects were divided into two groups: control group and treatment group which was exposed to 50% food restriction (FR 50%). At day 21, both group sacrificed and the cerebrum and cerebelum of the offsprings were prepared and stained with silver impregnation. We used parametric independent t-test in analyzing dendritic density.Results: In the cerebrum there was a significant difference in dendritic density between control (4.98+2.17) and treatment (2.69+0.76) groups with p=0.001 (p<0.05). In the cerebellum there was ALSO a significant difference in dendritic density between control (7.37+2.23) and treatment groups (3.01+0.64) with p=0.000 (p<0.05).Conclusions: The dendritic density of cerebrum and cerebellum of newborn Rattus norvegicusexposed to 50 percent of food restriction during pregnancy  were lower than control.
Resurgence of placenta accreta in Indonesia
Authors: Aditya Rozi
Published: February 2019

Placenta accreta is a common term used for defining a clinical condition which part or all of the placenta attaches to the myometrium that difficult to remove. Placenta accreta is a placental disorder which has been around for a long time and became a resurgence in Indonesia since 2016 with its incidence reached 2% and is still increasing until now. Placenta accreta is one of the most terrifying conditions faced by gynecologists and resulted in the increase of mortality and morbidity of pregnant women in Indonesia. In the United States, the incidence increased from less than 1 per 2000 pregnancies in 1980 to around 1 per 500 pregnancies until recently. The increased cases of placenta accreta is always directly proportional to the cesarean delivery rates.
An Overview of Convolutional Neural Network: Its Architecture and Applications
Authors: Sakib Shadman , Ahmed Nazib , Kabir Ahmed Jawad , Ahmed Hridon
Published: February 2019

With the increase of the Artificial Neural Network (ANN), machine learning has taken a forceful twist in recent times. One of the most spectacular kinds of ANN design is the Convolutional Neural Network (CNN). The Convolutional Neural Network (CNN) is a technology that mixes artificial neural networks and up to date deep learning strategies. In deep learning, Convolutional Neural Network is at the center of spectacular advances. This artificial neural network has been applied to several image recognition tasks for decades and attracted the eye of the researchers of the many countries in recent years as the CNN has shown promising performances in several computer vision and machine learning tasks. This paper describes the underlying architecture and various applications of Convolutional Neural Network.
Stag Beetle Elytra: Localized Shape-Retaining, Puncture and Wear-Resistant
Authors: Kundanati Lakshminath , Guarino Roberto , Pugno Nicola M.
Published: February 2019

Beetles are by far one of the most successful and diverse insect species. A part of this success is attributed to their elytra which provide various functions such as protection to their bodies from mechanical forces and the harmful environmental factors. In this study, Stag beetle (Lucanus cervus) elytra were first examined for their overall flexural properties and were observed to have a localized shape retaining snap-through mechanism which could play a crucial role in energy absorption, e.g. during battles and falls from heights. The snap-through mechanism was validated using theoretical calculations and also finite element simulations. Elytra were also characterized to examine their puncture and wear resistance. Our results show that elytra resisted puncture up to a force of 1.8±0.4 N and have puncture resistance compared to that of commercially available puncture resistant gloves. The measured values of modulus and hardness of elytra exocuticle were 10.3±0.8 GPa and 0.7±0.1 GPa. Using the hardness to modulus ratio as an indicator of wear resistance, the estimated value was observed to be in the range of wear resistant biological materials. Thus, our study demonstrates different mechanical properties of the stag beetle elytra which can be explored to design shape retaining bio-inspired composites with enhanced puncture and wear resistance.
PM10 and CO Dispersion Modeling of Emissions from the Four Thermal Power Plants in Mashhad-Iran
Authors: Moharreri Amir Mohammad , Arkian Foroozan , Lari Kamran , Salehi Gholam Reza
Published: February 2019

Population and industrial growth in Mashhad city, North-East of Iran, have led to increasing episodes of severe air pollution in urban areas. In this study, we present an evaluation of the (PM10) and carbon monoxide (CO) particulate matter exposure level originated from the four power plants in the area using Air Pollution Dispersion Model. Combined use of AREMOD (The American Meteorological Society/Environmental Protection Agency Regulatory Model), ArcGIS and health risk assessment were applied to estimate the level of pollution in thirteen municipal receptors in the city. The results indicated the long-range transport of the pollutants from the power plants expected to impose significant health impacts on residential receptors. Almost 80000 inhabitants of the city were exposed to PM10 concentration, ranging between 50-75 µg/m3 and 100000 were exposed to CO concentration, ranging between 40-45 µg/m3. Approximately, 1200 hectares of the city were exposed to PM10 concentration, ranging from 40 to 50 µg/m3 and 370 hectares of the city area were exposed to CO concentration between 50-75 µg/m3. Comparison between simulated and observed concentrations of pollutants shows a little overestimation by model.
ANALISA FAKTOR-FAKTOR INTRINSIK DAN KEUANGAN PERUSAHAAN DENGAN TRIPPLE BOTTOM LINES SEBAGAI VARIABEL PEMEDIASI TERHADAP NILAI PERUSAHAAN
Authors: Sari Mia Andika , Wiralaga Harya Kuncara , Warokka Ari
Published: February 2019

ABSTRAK

Penelitian ini dilakukan untuk menguji pengaruh faktor-faktor intrinsik yang diproksikan dengan struktur modal, ukuran perusahaan, usia perusahaan dan faktor keuangan yang diproksikan dengan likuditas, profitabilitas, serta aktivitas dengan tripple bottom lines sebagai variabel mediasi terhadap nilai perusahaan sektor perusahaan properti. Data yang digunakan dalam penelitian ini diperoleh dari laporan keuangan publikasi selama periode 2010 sampai dengan 2013, serta laporan tahunan yang dapat diakses melalui website idx. Teknik analisa data yang digunakan dalam penelitian ini adalah regresi dengan data panel dan analisa jalur (path analysis). Hasil penelitian menunjukkan bahwa variabel faktor intrinsik dan keuangan memiliki pengaruh signifikan terhadap nilai perusahaan, begitu pula variabel faktor intrinsik dan keuangan memiliki pengaruh signifikan terhadap tripple bottom lines. Dari Hasil analisa path dibuktikan bahwa pengaruh tidak langsung dengan menggunakan tripple bottom lines sebagai variabel mediasi lebih besar total pengaruhnya dibandingkan dengan pengaruh langsung.

 

Kata kunci : Faktor Intrinsik, Faktor Keuangan, Nilai Perusahaan, Tripple Bottom Lines.
Pengaruh Kepuasan Kerja, Keterlibatan Kerja, dan Perceived Organizational Support Terhadap Komitmen Organisasional Pada Bank Syariah Mandiri
Authors: Asrunputri Aisyah Pia
Published: February 2019

Tujuan dari penelitian ini adalah untuk mengukur pengaruh kepuasan kerja, keterlibatan kerja, dan perceived organizational support terhadap komitmen organisasional pada Bank Syariah Mandiri kantor pusat di Jakarta. Yang menjadi latar belakang penelitian ini adalah dikarenakan adanya penurunan presentase dalam kenaikan nilai aset perbankan yang disebabkan oleh kurang berkomitmen dan kurangnya keterlibatan karyawan didalam organisasi. POS yang diberikan oleh Bank Syariah Mandiri kepada karyawan juga dinilai kurang mencukupi kebutuhan sosio-emosional karyawan. Metode yang digunakan adalah kuantitatif yang memfokuskan pada 60 responden yakni karyawan di Bank Syariah Mandiri Kantor Pusat Jakarta. Berdasarkan temuan didalam penelitian ini membuktikan bahwa tidak ditemukannya hubungan positif antara kepuasan kerja dan komitmen organisasional serta POS dan komitmen organisasional. Namun ditemukan hubungan positif dan signifikan antara keterlibatan kerja dan komitmen organisasional.
Financial Analisis Pengaruh Faktor Fundamental dan Teknikal Terhadap Return Saham
Authors: Silvatika Bayu Anggara , Widiyanti Marlina
Published: February 2019

This research aims to examine the impact of fundamental and technical factors towards stock returns, and with macroecomoic as moderation variable. The population used in this research is all public companies or issuer listed in Indonesia Stock Exchange from 2008 to 2012. The companies used samples are 23 companies which categorized as LQ-45 that exist from 2008 to 2012 or using Purposive Sampling Method.

            Analysis of securitas consist of fundamental and technical analysis. In fundamental analysis and technical, analist often uses factors fundamental and technical. Fundamentalâ€™s and technicalâ€™s factors in Multi-factor Models uses to perform the portfolio with special characteristics. Multi-factor Models are improved from the concept of Arbitrage Pricing Theory (APT).

Fundamental factors are consisted Financial Ratio (ROA, DER, EPS, PBV) and macroeconomic (exchange rate, inflations, gdp); than technical factors (trading volume, market capitalization, and previous stock price). Those are independen variables which towards stock return using Panelâ€™s Data then make analysis using Multiple Regressions.

            This research shows that partially, several fundamental factors (ROA, DER, and EPS) have not significant influence and positif are toward stock return. However, PBV have significant influence and negatif are toward stock return. Several macro economicâ€™s factors (kurs and GDP) have significant influence and positif are toward stock return, but inflation have significant influence at Î± = 10%. All of technicalâ€™s factors (trading volume, market capitalization, and previous stock price) have not significant influence and positif (market capitalization, and previous stock price), negatif (trading volume) are toward stock return.Simultaneously, fundamentalâ€™s factors, macro economic, and technicalâ€™s factors have significant influence and positif are toward stock return.

            Managerial implication of this research are the investors can use fundamentals analysis with focus on PBV ratio, emiten must be more attention macro economic factors, especially exchange rate and GDP. Investors in Indonesia Stock Market more like fundamentalâ€™s analysis than technicalâ€™s analysis, but investor also can use integrated analysis by combine of fundamental and technicalâ€™s analysis.
Pengaruh Kualitas Pelayanan terhadap Kepuasan Konsumen Bis Transjakarta di Terminal Kampung Melayu
Authors: Elfian Elfian , Ariwibowo Prasetio
Published: February 2019

Tujuan  penelitian  ini  adalah  untuk  mengetahui  atas  pengaruh kualitas pelayanan  terhadap  kepuasan  konsumen bis Transjakarta  di  Terminal Kampung Melayu. Penelitian ini menggunakan teknik analisis deskriptif kuantitatif yang dilaksanakan di Terminal Kampung Melayu dengan metode purpossive sampling berjumlah 100 orang pada penumpang bis Transjakarta secara acak, baik ketika jam-jam sibuk pada pagi dan sore hari, maupun saat-saat sepi penumpang pada menjelang siang hari. Pengumpulan data melalui wawancara, angket kuisioner, pengumpulan ujian (tes), dokumentasi dan lainnya. Pada penelitian ini data diolah menggunakan tabulasi korelasi regresi sederhana, korelasi product moment, dan analisa koefisien determinasi pada software microsoft excel 2010 terhadap kepuasan konsumen.

Hasil penelitian dapat disimpulkan bahwa kepuasan konsumen adalah sebesar 12,496 dan b sebesar 0,520, artinya setiap kenaikan per satu satuan pada kualitas pelayanan maka akan naik kepuasan konsumen sebesar 0,520. Kemudian nilai r = 0,533, ini menunjukkan ada hubungan yang sedang atau cukup signifikan antara variabel X (kualitas pelayanan) dengan variabel Y (kepuasan konsumen). Dan nilai determinasi 28,41% menunjukan bahwa kontribusi variabel X (kualitas pelayanan) terhadap variabel Y (kepuasan konsumen) sebesar 28,41% dan sisanya sebesar 71,59% ditentukan oleh faktor lain yang tidak dibahas dalam penelitian ini.

Pengujian hipotesis yang dilakukan dapat memperkuat penelitian ini yaitu  menunjukkan bahwa t-hitung lebih besar dari ttabel yaitu 6,140 > 1,9855 yang menyatakan bahwa terdapat hubungan yang signifikan antara kualitas pelayanan terhadap kepuasan konsumen.
Analisa Strategi Bisnis PT. Wijaya Karya (Persero) tbk. Dalam Industri Pembangkit Listrik Nasional
Authors: Harahap Arpan Fadly , Hendrawati Ernie
Published: February 2019

Penelitian ini bertujuan untuk mencari penyebab kurang bersaingnya perusahaan pada industri pembangkit listrik dengan melakukan analisa strategi bisnis yang sesuai dengan situasi perusahaan. Analisis tersebut menggunakan pendekatan audit strategis dari wheelan. Peneliti melakukan analisis lingkungan eksternal dan lingkungan internal perusahaan kemudian menyusun perumusan strategi. Tujuan melakukan analisis lingkungan eksternal tersebut untuk mengetahui peluang dan ancaman yang dihadapi perusahaan meliputi tingkat persaingan dalam industri, ancaman masuknya pendatang baru, daya tawar pembeli / konsumen, daya tawar pemasok, dan ancaman produk subtitusi. Tujuan analisis lingkungan internal  dilakukan untuk mengetahui kinerja perusahaan meliputi aspek pemasaran, aspek keuangan, aspek penelitian dan pengembangan, aspek produksi-operasi -logistik, aspek sumber daya manusia dan aspek sistem informasi manajemen. Hasil penelitian menunjukkan bahwa terdapat kelemahan sumberdaya manusia pada bidang operasi-pemeliharaan, pemasaran-estimasi, manajemen risiko dan administrasi kontrak perjanjian. Selain itu, perlu diperhatikan bawah beragamnya merk mesin dan peralatan digunakan, kepemilikan sumber daya peralatan pemeliharaan mesin pembangkit, penerapan sistem manajemen pengendalian operasional pembangkit dengan sistem pengendalian konstruksi menjadi faktor yang harus diperbaiki. Untuk itu, perusahaan menyusun ulang strategi bisnis dengan peningkatan kompentensi sumberdaya manusia, pemilihan mesin dan teknologi yang sejenis dan penetrasi pasar serta fokus pada pembentukan unit usaha yang tersendiri.

Kata kunci : Strategi Bisnis, Audit Strategis Whelan, Analisa Lingkungan Industri,  Analisa Lingkungan Fungsional
İNŞAAT SEKTÖRÜNDE KAYIT DIŞI İSTİHDAMIN İNCELENMESİ: DENİZLİ İLİ ÖRNEĞİ
Authors: ŞENEL Dilek
Published: February 2019

Kayıt dışı istihdam, kayıt dışı ekonominin bir yansıması olarak karşımıza çıkmaktadır. Kayıt dışılık, birçok gelişmekte olan ülkede olduğu gibi Türkiye’de de sosyal ve ekonomik sorunlara yol açmaktadır. Kayıt dışı istihdam, bazen yapılan faaliyetlerin ilgili kurum ve kuruluşlara hiç bildirilmemesi şeklinde ortaya çıkmaktadır. Bazen de yapılan faaliyetlerin ilgili kurum ve kuruluşlara gerçek değerleri üzerinden bildirilmemesi şeklinde ortaya çıkabilmektedir. Ancak ne şekilde olursa olsun, kayıt dışılığa ilişkin kayıplar, ülke ekonomilerini gün geçtikçe daha fazla yormaktadır. Bu çalışma Türkiye’de TR 32 bölgesinde inşaat sektöründe faaliyet gösteren firmaların kayıt dışılığa ilişkin durumlarını ortaya koymaktadır. Bu bağlamda Türkiye İstatistik Kurumu 2016 yılı Hane Halkı İşgücü Anketi ve Gelir Yaşam Koşulları mikro veri setlerinden yararlanılmıştır. Öte yandan Denizli ilinde inşaat sektöründe faaliyet gösteren firmalarda yer alan işçi ve işverenlerle derinlemesine mülakatlar yapılmıştır. Çalışma kapsamında; inşaat sektöründe kayıt dışı çalışmanın, genel kayıt dışılık oranına göre daha yüksek olduğu, ancak TR 32 bölgesinde inşaat sektöründe faaliyet gösterenlerin, genele oranla daha az kayıt dışı çalıştıkları tespit edilmiştir. Türkiye dışında doğanların yaklaşık %78’inin kayıt dışı çalıştığı, okuma yazma bilmeyenlerin, okuma yazma bilenlere göre daha fazla kayıt dışı çalıştığı, yarı zamanlı çalışanların, tam zamanlı çalışanlara göre daha fazla kayıt dışı çalıştığı tespit edilmiştir. Ayrıca bireylerin geliri arttıkça kayıt dışılığın azaldığı saptanmıştır.
TÜRKİYE’DE 2001 YILI VE SONRASINDA UYGULANAN SPOR EKONOMİSİ POLİTİKALARINA YÖNELİK BİR DEĞERLENDİRME
Authors: SİVRİKAYA Kenan , DEMİR Ayşe
Published: February 2019

Küreselleşme ile birlikte, ekonominin en temel var oluş nedeni olan arz ve talep dengesinin korunması ve iletişim teknolojilerindeki gelişmeler ile paralel olarak bireysel ihtiyaçların artması nedeniyle var olan kaynakların etkin ve verimli kullanılmasının önemi giderek artmıştır ve spor sektörü önemi artan sektörlerden biridir. Dünyanın en büyük hizmet sektörlerinden biri olarak kabul edilen, sürekli olarak gelişen ekonomik hacmiyle birçok ülkede ekonomilerin lokomotif sektörlerinden biri olan sektöre yönelik olarak gelişen spor-ekonomi ilişkisini; pazarlama, spor işletmeleri, spor teşkilatları, spor ürünleri/hizmetleri, spor medyası, spora yönelik teknoloji, spora yönelik organizasyonlar temelinde geliştiren spor ekonomisi günümüzün popüler disiplinlerinden bir tanesidir. Spor ekonomisine yönelik olarak mikro ve makro düzeyde; politikalar, planlar, stratejiler geliştirmekte ve bu kapsamda, spor sektörüne yönelik yeni iş fırsatlarının ortaya çıkması, eğitim süreçlerinde spor tabanlı yeni programların ve projelerin hayata geçirilmesi, bireyler arasındaki ekonomik, kültürel, sosyal etkileşim-iletişimin kuvvetlendirilmesi amaçlanmaktadır. Yürütülen bu çalışmanın amacı, Türkiye’de uygulanan spor ekonomisi politikalarının 2001’den günümüze, kalkınma planları, spora ayrılan bütçeler ve stratejik hedefler çerçevesinde değerlendirilerek Türk spor ekonomisine yönelik çerçeve belirlemektir. Uygulanan politikalar, hukuki altyapı, bütçe, kalkınma planları, uygulamalar ve sonuçların değerlendirilmesiyle varılan temel sonuç, Türkiye’de küresel düzeyde sportif başarılar elde edilmesi noktasında spor ekonomisine daha fazla değer verilmesi ve spora yönelik stratejik hedeflerin daha etkin uygulanmasıdır.
DUYGUSAL EMEK İLE İŞ DOYUMU ARASINDAKİ İLİŞKİ: HEKİMLER ÜZERİNDE BİR UYGULAMA
Authors: KILIÇASLAN Semiha
Published: February 2019

Duygusal emek; kişilerarası etkileşim sırasında, örgütün talep ettiği duyguların, çalışanlar tarafından sergilenmesi anlamına gelmektedir. Diğer bir ifadeyle, “başkaları tarafından gözlemlenebilecek şekilde, yüz ve bedensel gösterim aracılığıyla duyguların yönetilmesi” olarak da tanımlanmaktadır. İş doyumu ise; bireyin işine karşı tutumu olarak değerlendirilmektedir. Buna göre bireyin işine karşı pozitif duyguları varsa iş doyumundan, negatif duyguları varsa iş doyumsuzluğundan söz edilmektedir. Araştırmanın amacı; duygusal emek boyutlarının iş doyumu üzerinde yarattığı etkiyi belirlemektir. Bununla birlikte çalışanların demografik özelliklerinin (yaş, eğitim, medeni durum, kıdem, unvan) iş doyumu ile aralarındaki ilişkiyi incelemek de araştırmanın bir diğer amacını oluşturmaktadır. Bu amaçla araştırmada anket yöntemi uygulanmıştır. Araştırmanın örneklemi Elazığ Fırat Üniversitesi Araştırma Hastanesinde görev yapan hekimlerdir. Araştırmada kullanılabilir durumda olan toplam 109 adet soru formu, araştırma kapsamına alınmıştır. Araştırmada elde edilen bulgulara göre, iş doyumunun demografik faktörlere göre farklılık gösterdiği belirlenmiştir. İş doyumu ile duygusal emek boyutlarından samimi (doğal) davranış arasında pozitif yönlü ve orta düzeyde, yüzeysel davranış ile negatif yönlü ve düşük düzeyde ilişki gözlenirken, derinlemesine davranış ile iş doyumu arasında anlamlı bir ilişki olmadığı sonucuna ulaşılmıştır.
TERMAL OTEL İŞLETMELERİNDE JEOTERMAL KAYNAK KULLANIMININ YÖNETİCİ BAKIŞ AÇISIYLA DEĞERLENDİRİLMESİ: DENİZLİ İLİ ÖRNEĞİ
Authors: BOYRAZ Mehmet , ÇETİN Ahmet
Published: February 2019

Bu araştırmanın amacı, termal otel işletmelerinde jeotermal kaynakların temini, kullanım alanları, avantaj ve dezavantajları, jeotermal kaynakların kullanımına ilişkin uygulanan çevresel ilkeler ile bu alanda karşılaşılan sorunların tespit edilmesi ve önerilerle bir bütün olarak ele alınmasıdır. Araştırmanın evrenini, Denizli’de faaliyet gösteren turizm işletme belgesine sahip yedi termal otel işletmesinin üst ve orta düzey yöneticileri oluşturmaktadır. Araştırmada herhangi bir örneklem alınmayarak tam sayım yapılmıştır. Verilerin toplanmasında nitel araştırma yöntemlerinden görüşme tekniğinden yararlanılmıştır. Bu kapsamda yöneticilere; demografik karakteristikler ve tesis özellikleri ile araştırmaya ilişkin üç bölümden oluşan 24 adet yarı yapılandırılmış görüşme sorusu yöneltilmiştir. Elde edilen verilerin çözümlenmesinde içerik analizi yönteminden faydalanılmıştır. Araştırma sonucunda, termal otel işletmelerinin jeotermal kaynak suları; çoğunlukla belediyelerden, bir kısmı ise kendine ait termal kuyulardan sağladığı; termal suların otellere ulaştırılabilmesi için merkezi dağıtım şebekesinin bulunmadığı, her tesisin belediye kuyularından termal su tedarik edebilmek için kendi taşıma sistemini kurması gerektiği saptanmıştır. Denizli bölgesinde, re-enjeksiyon alt yapısının olmaması ve sağlık sorunları gerekçesiyle hiçbir otelin termal suların geri dönüşümü ile ilgili bir çalışmasının olmadığı sonucuna ulaşılmıştır. Araştırma kapsamında, jeotermal kaynak suların enerji kaynağı olarak kullanımı sayesinde, enerji maliyetlerinin düştüğü; LNG, doğalgaz ya da fosil yakıtların kullanımının azalması ile çevre kirliliğinin önlendiği ve termal otellerin gelirlerinin dolaylı yönden arttığı belirlenmiştir.
TFRS’NİN FİNANSAL RAPORLARA ETKİSİNİN DEĞER İLGİSİ İLE TESPİTİ: BİST İMALAT SANAYİ SEKTÖRÜNDE BİR UYGULAMA
Authors: ORAL İnci Çisil , BEKCİ İsmail
Published: February 2019

Bu çalışma Türkiye’de Türkiye Finansal Raporlama Standartları (TFRS) uygulamalarının öncesi ve sonrası dönem için finansal raporlardan elde edilen ve bilanço ve gelir tablosunda yer alan muhasebe verilerinin değer ilgisi düzeyini incelemektedir. Çalışma, TFRS uygulamasından önceki altı yıllık (1999 - 2004) ve TFRS uygulamasından sonraki on iki yıllık dönem (2005 - 2016) üzerine odaklanmıştır. Bu amaçla Borsa İstanbul’da imalat sanayi sektöründe işlem gören 40 işletmenin verileri panel veri analizi yöntemi ile analiz edilmiştir. Çalışma sonunda özkaynak defter değeri ile işletmelerin piyasa değeri arasındaki ilişkinin TFRS sonrası dönem için arttığı tespit edilmiştir. Ayrıca net kardaki değişim ile hisse senedi getirisi arasındaki ilişki de TFRS öncesi ve sonrası dönemler için test edilmiştir. Yapılan analizler sonunda yatırımcıların hisse senedi getirilerini analiz ederken net kardaki değişimden faydalanmayı tercih ettikleri gözlemlenmiştir.
Experimental effect of medium ratio on removal efficiency of nitrate nitrogen in groundwater by zero-valent iron, activated carbon and zeolite
Authors: Cao Sizhi , Liu Peigui , Liu Mingchao , Wang Gang , Li Zaili , Tong Yansong , Huang Zhiqiang
Published: February 2019

In this study, column experiments in the laboratory were set up to examine how the concentrations of nitrate nitrogen, nitrite nitrogen, and ammonia nitrogen changed when a nitrate-rich solution was passed through a medium comprising zero-valent iron, activated carbon, zeolite, and coarse sand. We varied the proportions of the components of the medium to determine how it influenced the nitrate removal and nitrogen fractions. Three different scenarios were used, with: (1) iron, activated carbon, and coarse sand at a ratio of 3:1:6; (2) iron, activated carbon, and zeolite at a ratio of 3:1:6; and (3) iron, activated carbon, and zeolite at a ratio of 3:3:4. The nitrate nitrogen concentration decreased from 25 mg/L to 2 mg/L in the first scenario. Removal was better when zeolite was added to the medium as most of the nitrate nitrogen broke down to ammonia nitrogen, with nitrite nitrogen as an intermediate product. The results of the tests showed that nitrate removal was best when the medium was iron, activated carbon, and zeolite, mixed at a ratio of 3:1:6. This study provides a scientific reference for in situ remediation of nitrate pollution in groundwater.
Article Reviews
Authors: Chin Kelly
Published: February 2019

Summaries and commentaries from the section editors and invited reviewers present a clinical context for practitioners' application of the latest published research relevant to the care of patients with pulmonary hypertension. In this issue Kelly Chin, MD,, discusses 2 recently published articles regarding medication and drug exposures in PH patients.
Preoperative Assessment and Management of Liver Transplant Candidates With Portopulmonary Hypertension
Authors: Cartin-Ceba Rodrigo , Krowka Michael J.
Published: February 2019

Pulmonary artery hypertension (PAH) that occurs as a consequence of portal hypertension is termed portopulmonary hypertension (POPH) and is associated with significant morbidity and mortality. Among liver transplant (LT) candidates, reported incidence rates of POPH range from 4.5% to 8.5%. The severity of POPH is unrelated to the severity of portal hypertension or the liver disease. In LT patients, intraoperative death and immediate post-LT mortality are feared clinical events when transplantation is attempted in the setting of untreated, moderate to severe POPH. Specific pulmonary artery vasodilator medications (PAH-specific therapy) appear effective in reducing pulmonary artery pressures, improving right ventricular (RV) function and survival. Thus, screening for and accurately diagnosing POPH prior to LT has become a standard of care. The post-LT course of patients with moderate POPH is unpredictable, but most patients can be weaned from PAH-specific therapy over time. In this article, we present an overview of the preoperative assessment of POPH with an emphasis on risk assessment for transplant and the most recent medical treatment options.
Perioperative Evaluation and Management of Patients With Portopulmonary Hypertension Aiming for Orthotopic Liver Transplantation
Authors: Díaz-Gómez José L. , Franco Pablo Moreno , Canabal Juan M. , Irefin Samuel , Burger Charles D.
Published: February 2019

Background: Portopulmonary hypertension (POPH) is defined as pulmonary arterial hypertension (PAH) in the context of portal hypertension. Severe POPH has been considered an absolute contraindication of orthotopic liver transplantation (OLT).

Objective: Since there are no definitive guidelines for the immediate preoperative, intraoperative, and postoperative evaluation and treatment of POPH patients, we have used published literature along with our experience to review current knowledge in this area.

Summary: Moderate-to-severe POPH has important consequences in the perioperative management of candidates for OLT. Adequate right ventricular function is critical to survive the hemodynamic burden of OLT. Immediate preoperative assessment of hemodynamics; careful intraoperative monitoring and management of volume status, pressure changes, and ventricular function; and postoperative transitions of PAH-specific therapy are key components to successful OLT. We emphasize the advantages of the echocardiogram during all of these phases and stress the importance of a team approach to plan care and respond to the multiple challenges of OLT in POPH.