bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurosurgical sequelae of domestic dog attacks in children
Authors: Kumar Ramesh , Deleyiannis Frederic W. B. , Wilkinson Corbett , O'Neill Brent R.
Published: October 2016

OBJECTIVE

The authors' goals in this study were to describe a series of dog attacks on children that required neurosurgical consultation and to better understand the pattern of injuries inflicted, the circumstances that place children at risk for attack, and the dog breeds involved. In addition, the authors review the surgical and medical management of these patients.

METHODS

The authors performed a retrospective review of all children requiring neurosurgical consultation for dog bite at a regional Level 1 pediatric trauma center over a 15-year period.

RESULTS

A total of 124 children with dog bites to the head, face, and neck were evaluated in the emergency department. Of these, 17 children (13.7%) incurred injuries requiring neurosurgical consultation. Fifty-three percent of victims were female. The mean age at the time of attack was 30 months. Twelve (71%) of the attacks were perpetrated by the family pet, and 13 (76%) occurred at the patient's home. Breeds involved in the attacks included German Shepherd, Pit Bull, American Bulldog, large mixed breed, Labrador Retriever, and Akita, with German Shepherds and Akitas being the most frequently involved. Neurosurgical injuries included nondepressed skull fracture in 5, depressed skull fracture in 10, intracranial hemorrhage in 5, cerebral contusions in 4, dural laceration in 4, pneumocephalus in 5, clinically evident CSF leak in 3, spinal fracture with complete spinal cord injury in 1, stroke in 2, vascular injury in 2, and cranial nerve injury (hypoglossal and facial nerve) in 1. Prophylactic antibiotics were administered in 16 patients (94%). Only 1 patient had a confirmed infection involving the site of injury. Neurosurgical intervention was required in 10 patients (59%) and ranged in severity from debridement and closure of a complex scalp wound to decompressive craniectomy. Neurological deficits, all of which were considered catastrophic, developed in 3 patients (18%).

CONCLUSIONS

Dog attacks on children requiring neurosurgical consultation commonly involve the family pet, which is usually a large-breed dog with no history of prior aggression. Neurosurgical injuries often involve the cranial vault, with depressed skull fractures being the most common injury pattern. Most patients do not suffer a neurological deficit, although catastrophic neurological injury may occur. Prophylactic antibiotics are commonly used and surgical intervention is required in the majority of cases.
Quality of life of cervical cancer patients after completion of treatment -A study among Bangladeshi women
Authors: Hossain Nasrin , Akter Qazi Mobina , Banu Farzana , Mahmud Sharif
Published: October 2016

Cervical cancer is the main cause of malignancy-related death among women living in developing countries. The aim of this study is to evaluate the quality of life (QOL) among Bangladeshi cervical cancer survivors and its relationships with demographic and disease related factorsA cross-sectional study was carried out on one hundred nine consecutive cervical cancer survivors in National Institute of cancer Research and Hospital, Dhaka from September 2014 to february2015 using European organization for Research and treatment of cancer core Questionnaires (QOL-C30 and QOL-CX24). Demographic condition like education level, occupation and disease related factors like stages, treatment modality and duration of follow-up time were taken as investigating factors against functional scales. Cronbach´s alpha was calculated to asses internal consistency among items.Cervical cancer survivors stated a moderate QOL. Sub-domains of QOL score and global health status were significantly associated with physical function(PF) scales (p=.000), fatigue (p=.045), nausea and vomiting (p=.000), Appetite loss (p=.001), constipation (p=.005), symptom experience (p=.005) and menopausal symptoms (p=.015). QOL mean score were negatively associated with emotional function(EF) scales, pain, fatigue, nausea, appetite loss and financial problems. Education level showed significant association with physical function(PF) (p=.001), emotional function(EF) (p=.027), Cognitive function(CF) (p=.000) and sexual function (p=.001). Duration (Follow-up) time was significance association with PF (p=.005), EF (p=.012), symptoms experience (p=.001). Although, the QOL in cervical cancer survivors was moderate, treatment of related symptoms and improvement of demographic condition can influence the QOL and survivors improve the care of cervical cancer. So, improve the QOL among cervical cancer survivors.
Aeromedical Evaluation for an F-16 Candidate with Incomplete Paraplegia
Authors: Chahal-Kummen Monica , Strand Trond-Eirik , Owe Jan Ove , Gulliksen Eigil , Wagstaff Anthony S.
Published: October 2016

BACKGROUND: A candidate with paraplegia contacted the Institute of Aviation Medicine, Oslo, requesting a medical examination and medical certification for flying back seat on an F-16 Fighting Falcon. Thorough aeromedical examinations, including specialist evaluations, were initiated
for the final decision to be made.CASE REPORT: Almost 13 yr earlier the candidate had acquired spinal cord damage at neurological level L1 after falling 4 m (13 ft) from out of a window. The CT scans showed luxation of the 12th thoracic vertebra with fracture and dislocation
of the 1st lumbar vertebra. He went for surgery, where fixation of the 12th thoracic vertebra to the 1st lumbar vertebra was performed. He developed syringomyelia 1 yr postoperatively and was re-operated on twice in the following years. He was now in a wheelchair,
but engaged himself in several sport activities such as sledge-hockey and sit-skiing, participating in several Paralympics.DISCUSSION: With respect to the general principles of aviation medicine, several considerations had to be taken into account before a medical certification
could be given. The risks associated with an F-16 flight in relationship to the candidate's general health and the fixation of his spinal cord had to be evaluated. Also, his ability to perform required tasks during the flight and in case of an emergency was an important issue discussed. Finally,
the candidate’s medical and physical condition should not present a considerable risk to flight safety. After extensive specialist consultations and in-depth discussions, the candidate was given medical certification to fly back seat in a F-16.Chahal-Kummen M, Strand T-E, Owe JO,
Gulliksen E, Wagstaff AS. Aeromedical evaluation for an F-16 candidate with incomplete paraplegia. Aerosp Med Hum Perform. 2016; 87(11):968–971.
Autonomous, Computer-Based Behavioral Health Countermeasure Evaluation at HI-SEAS Mars Analog
Authors: Anderson Allison P. , Fellows Abigail M. , Binsted Kim A. , Hegel Mark T. , Buckey Jay C.
Published: October 2016

INTRODUCTION: Living in an isolated, confined environment (ICE) can induce conflict, stress, and depression. Computer-based behavioral health countermeasures are appealing for training and treatment in ICEs because they provide confidentiality and do not require communication
with the outside environment. We evaluated the Virtual Space Station (VSS), a suite of interactive computer-delivered psychological training and treatment programs, at the Hawaii Space Exploration Analog and Simulation (HI-SEAS) III expedition.METHODS: Six subjects (3 male, 3 female)
spent 8 mo in group-isolation and used the Conflict, Stress, and Depression modules in the VSS. Survey evaluations, data collected within the program, and postdeployment interviews were collected.RESULTS: This crew dealt with behavioral health issues common to ICEs. The VSS proved
to be a valuable resource and was used both as intended, and in unanticipated ways, to help maintain behavioral health. The Conflict and Stress Modules were rated as highly acceptable (1.8 on a 7-point Likert scale). The crew identified a total of 13 stressors and worked on 9 problems through
the VSS. Opinions about the modules were highly individualized. Crewmembers identified exercises in the VSS that were applicable and not applicable to their needs. Additional content to improve the program was identified.DISCUSSION: Autonomous, confidential training and treatment
for behavioral health issues will need to be a critical component of long duration spaceflight travel. This work provides an evaluation of such a tool in a relevant ICE.Anderson AP, Fellows AM, Binsted KA, Hegel MT, Buckey JC. Autonomous, computer-based behavioral health countermeasure
evaluation at HI-SEAS Mars analog. Aerosp Med Hum Perform. 2016; 87(11):912–920.
Design, Production, and Installation of Wooden Walls for the Japan Pavilion at Expo 2015
Authors: Cipollini Matteo , Bonannini Elisa , Cinotti Marco , Sassu Mauro
Published: October 2016

This article illustrates the production process, the structural calculations and the assembly phases of the wooden walls of the Japan Pavilion at Expo 2015 in Milan, designed by Atsushi Kitagawara Architects (AKA). The pavilion, one of the most popular construction of this international event, was built almost exclusively with precast interlocking. The production process and the assembly phases were optimized to construct the wooden walls (with a height of 4–12 m) in a short time frame and with a high level of quality. Out-of-plane rocking and other aspects of structural safety were considered, to ensure sufficient stability of the walls.
Steady-State Thermal Properties of Rectangular Straw-Bales (RSB) for Building
Authors: Conti Leonardo , Barbari Matteo , Monti Massimo
Published: October 2016

Straw is an inevitable product of cereal production and is available in huge quantities in the world. In order to use straw-bales as a building material, the characteristic values of the thermal performances should be determined. To not lose the benefits of the cheapness and sustainability of the material, the characteristics must be determined with simple and inexpensive means and procedures. This research aims to implement tools and methods focused at the determination of the thermal properties of straw-bales. For this study, the guidelines dictated by ASTM and ISO were followed. A measurement system consisting of a Metering Chamber (MC) was realized. The MC was placed inside a Climate Chamber (CC). During the test, a known quantity of energy is introduced inside MC. When the steady-state is reached, all the energy put into MC passes through its walls in CC, where it is absorbed by the air-conditioner. A series of thermopiles detect the temperature of the surfaces of the measurement system and of the specimen. Determining the amount of energy transmitted by the various parts of MC and by the specimen, it is possible to apply Fourier’s law to calculate the thermal conductivity of the specimen.
Synthesis and Crystal Structures of Two New Oxaspirocyclic Compounds
Authors: Jiang Jinhe , Zeng Wulan
Published: October 2016

Two new oxaspirocyclic compounds, 8-(4-(dimethylamino)benzylidene)-6,10-dioxaspiro[4.5]decane-7,9-dione (1) and 8-(4-hydroxybenzylidene)-6,10-dioxaspiro[4.5]decane-7,9-dione (2) have been synthesized and their structures determined by single crystal X-ray crystallography. Compound 1, C17H19NO4, belongs to the monoclinic system, space group P21/c with a = 6.2554(13) Å, b = 14.605(3) Å, c = 16.265(3) Å, β = 95.97(3)°, V = 1477.9(5) Å3, Z = 4, Dc = 1.354 g/cm3, F(000) = 640, μ(MoKa) = 0.097 mm−1, the final R = 0.0570 and wR = 0.1667. Compound 2, C15H14O5, is also of the monoclinic system, space group P21/c with a = 10.739(2) Å, b = 18.348(4) Å, c = 6.7799(14) Å, β = 104.20(3)°, V = 1295.1(5) Å3, Z = 4, Dc = 1.407 g/cm3, F(000) = 608, μ(MoKa) = 0.106 mm−1, the final R = 0.0568 and wR = 0.1739. Some C–H···O intra- and intermolecular hydrogen bonds and π··· π stacking interactions are both observed in the two lattice structures. The difference between them is that one type of C–H···π supramolecular interaction (1) and one type of O–H···O intermolecular hydrogen bond (2) are observed.
The Land Surface Temperature Synergistic Processor in BEAM: A Prototype towards Sentinel-3
Authors: Ruescas Ana , Danne Olaf , Fomferra Norman , Brockmann Carsten
Published: October 2016

Land Surface Temperature (LST) is one of the key parameters in the physics of land-surface processes on regional and global scales, combining the results of all surface-atmosphere interactions and energy fluxes between the surface and the atmosphere. With the advent of the European Space Agency (ESA) Sentinel 3 (S3) satellite, accurate LST retrieval methodologies are being developed by exploiting the synergy between the Ocean and Land Colour Instrument (OLCI) and the Sea and Land Surface Temperature Radiometer (SLSTR). In this paper we explain the implementation in the Basic ENVISAT Toolbox for (A)ATSR and MERIS (BEAM) and the use of one LST algorithm developed in the framework of the Synergistic Use of The Sentinel Missions For Estimating And Monitoring Land Surface Temperature (SEN4LST) project. The LST algorithm is based on the split-window technique with an explicit dependence on the surface emissivity. Performance of the methodology is assessed by using MEdium Resolution Imaging Spectrometer/Advanced Along-Track Scanning Radiometer (MERIS/AATSR) pairs, instruments with similar characteristics than OLCI/ SLSTR, respectively. The LST retrievals were properly validated against in situ data measured along one year (2011) in three test sites, and inter-compared to the standard AATSR level-2 product with satisfactory results. The algorithm is implemented in BEAM using as a basis the MERIS/AATSR Synergy Toolbox. Specific details about the processor validation can be found in the validation report of the SEN4LST project.
Thermal Analysis of an Industrial Furnace
Authors: Filipponi Mirko , Rossi Federico , Presciutti Andrea , De Ciantis Stefania , Castellani Beatrice , Carpinelli Ambro
Published: October 2016

Industries, which are mainly responsible for high energy consumption, need to invest in research projects in order to develop new managing systems for rational energy use, and to tackle the devastating effects of climate change caused by human behavior. The study described in this paper concerns the forging industry, where the production processes generally start with the heating of steel in furnaces, and continue with other processes, such as heat treatments and different forms of machining. One of the most critical operations, in terms of energy loss, is the opening of the furnace doors for insertion and extraction operations. During this time, the temperature of the furnaces decreases by hundreds of degrees in a few minutes. Because the dispersed heat needs to be supplied again through the combustion of fuel, increasing the consumption of energy and the pollutant emissions, the evaluation of the amount of lost energy is crucial for the development of systems which can contain this loss. To perform this study, CFD simulation software was used. Results show that when the door opens, because of temperature and pressure differences between the furnace and the ambient air, turbulence is created. Results also show that the amount of energy lost for an opening of 10 min for radiation, convection and conduction is equal to 5606 MJ where convection is the main contributor, with 5020 MJ. The model created, after being validated, has been applied to perform other simulations, in order to improve the energy performance of the furnace. Results show that reducing the opening time of the door saves energy and limits pollutant emissions.
Deep Soil Conditions Make Mediterranean Cork Oak Stem Growth Vulnerable to Autumnal Rainfall Decline in Tunisia
Authors: Zribi Lobna , Mouillot Florent , Guibal Frederic , Rejeb Salwa , Rejeb Mohamed , Gharbi Fatma
Published: October 2016

Tree rings provide fruitful information on climate features driving annual forest growth through statistical correlations between annual tree growth and climate features. Indices built upon tree growth limitation by carbon sequestration (source hypothesis) or drought-driven cambial phenology (sink hypothesis) can be used to better identify underlying processes. We used both analytical frameworks on Quercus suber, a sparsely studied species due to tree ring methodological issues, and growing on a favorable sub-humid Mediterranean climate and deep soil conditions in Tunisia (North Africa). Statistical analysis revealed the major role of autumnal rainfall before the growing season on annual tree growth over the 1918–2008 time series. Using a water budget model, we were able to explain the critical role of the deep soil water refill during the wet season in affecting both the drought onset controlling growth phenology and the summer drought intensity affecting carbon assimilation. Analysis of recent climate changes in the region additionally illustrated an increase in temperatures enhancing the evaporative demand and advancing growth start, and a decline in rainfalls in autumn, two key variables driving stem growth. We concluded on the benefits of using process-based indices in dendrochronological analysis and identified the main vulnerability of this Mediterranean forest to autumnal rainfall decline, a peculiar aspect of climate change under summer-dry climates.
Senior Living Lab: An Ecological Approach to Foster Social Innovation in an Ageing Society
Authors: Angelini Leonardo , Carrino Stefano , Abou Khaled Omar , Riva-Mossman Susie , Mugellini Elena
Published: October 2016

The Senior Living Lab (SLL) is a transdisciplinary research platform created by four Universities that aims at promoting ageing well at home through the co-creation of innovative products, services and practices with older adults. While most living labs for ageing well are focused on Information and Communication Technologies (ICTs), this social laboratory adopts a transdisciplinary approach, bringing together designers, economists, engineers and healthcare professionals to develop multiple forms of social innovation using participatory methods. The SLL is based on an ecological approach, connecting professionals and users in a cooperative network and involving all of the stakeholders concerned with ageing well, such as existing associations, business entities and policy-makers. Three main themes for the co-design of products and services were identified at the beginning of the SLL conception, each sustained by a major business partner: healthy nutrition to cope with frailty, improved autonomous mobility to foster independence and social communication to prevent isolation. This article shows the innovative transdisciplinary approach of the SLL and discusses the particular challenges that emerged during the first year of its creation, investigating the role of ICTs when designing products and services for older adults.
Observations of the Structure and Dynamics of the Inner M87 Jet
Authors: Walker R. , Hardee Philip , Davies Fred , Ly Chun , Junor William , Mertens Florent , Lobanov Andrei
Published: October 2016

M87 is the best source in which to study a jet at high resolution in gravitational units because it has a very high mass black hole and is nearby. The angular size of the black hole is second only to Sgr A*, which does not have a strong jet. The jet structure is edge brightened with a wide opening angle base and a weak counterjet. We have roughly annual observations for 17 years plus intensive monitoring at three week intervals for a year and five day intervals for 2.5 months made with the Very Long Baseline Array (VLBA) at 43 GHz. The inner jet shows very complex dynamics, with apparent motions both along and across the jet. Speeds from zero to over 2c are seen, with acceleration observed over the first 3 milli-arcseconds. The counterjet decreases in brightness much more rapidly than the main jet, as is expected from relativistic beaming in an accelerating jet oriented near the line-of-sight. Details of the structure and dynamics are discussed. The roughly annual observations show side-to-side motion of the whole jet with a characteristic time scale of about 9 years.
Overexpression of RACK1 Promotes Metastasis by Enhancing Epithelial-Mesenchymal Transition and Predicts Poor Prognosis in Human Glioma
Authors: Lv Qiao-Li , Huang Yuan-Tao , Wang Gui-Hua , Liu Yan-Ling , Huang Jin , Qu Qiang , Sun Bao , Hu Lei , Cheng Lin , Chen Shu-Hui , Zhou Hong-Hao
Published: October 2016

Emerging studies show that dysregulation of the receptor of activated protein kinase C1 (RACK1) plays a crucial role in tumorigenesis and progression of various cancers. However, the biological function and underlying mechanism of RACK1 in glioma remains poorly defined. Here, we found that RACK1 was significantly up-regulated in glioma tissues compared with normal brain tissues, being closely related to clinical stage of glioma both in mRNA and protein levels. Moreover, Kaplan-Meier analysis demonstrated that patients with high RACK1 expression had a poor prognosis (p = 0.0062, HR = 1.898, 95% CI: 1.225–3.203). In vitro functional assays indicated that silencing of RACK1 could dramatically promote apoptosis and inhibit cell proliferation, migration, and invasion of glioma cells. More importantly, knockdown of RACK1 led to a vast accumulation of cells in G0/G1 phase and their reduced proportions at the S phase by suppressing the expression of G1/S transition key regulators Cyclin D1 and CDK6. Additionally, this forced down-regulation of RACK1 significantly suppressed migration and invasion via inhibiting the epithelial-mesenchymal transition (EMT) markers, such as MMP2, MMP9, ZEB1, N-Cadherin, and Integrin-β1. Collectively, our study revealed that RACK1 might act as a valuable prognostic biomarker and potential therapeutic target for glioma.
A Framework for Discovering Evolving Domain Related Spatio-Temporal Patterns in Twitter
Authors: Shi Yan , Deng Min , Yang Xuexi , Liu Qiliang , Zhao Liang , Lu Chang-Tien
Published: October 2016

In massive Twitter datasets, tweets deriving from different domains, e.g., civil unrest, can be extracted to constitute spatio-temporal Twitter events for spatio-temporal distribution pattern detection. Existing algorithms generally employ scan statistics to detect spatio-temporal hotspots from Twitter events and do not consider the spatio-temporal evolving process of Twitter events. In this paper, a framework is proposed to discover evolving domain related spatio-temporal patterns from Twitter data. Given a target domain, a dynamic query expansion is employed to extract related tweets to form spatio-temporal Twitter events. The new spatial clustering approach proposed here is based on the use of multi-level constrained Delaunay triangulation to capture the spatial distribution patterns of Twitter events. An additional spatio-temporal clustering process is then performed to reveal spatio-temporal clusters and outliers that are evolving into spatial distribution patterns. Extensive experiments on Twitter datasets related to an outbreak of civil unrest in Mexico demonstrate the effectiveness and practicability of the new method. The proposed method will be helpful to accurately predict the spatio-temporal evolution process of Twitter events, which belongs to a deeper geographical analysis of spatio-temporal Big Data.
Modification of Lightweight Aggregates’ Microstructure by Used Motor Oil Addition
Authors: Franus Małgorzata , Jozefaciuk Grzegorz , Bandura Lidia , Lamorski Krzysztof , Hajnos Mieczysław , Franus Wojciech
Published: October 2016

An admixture of lightweight aggregate substrates (beidellitic clay containing 10 wt % of natural clinoptilolite or Na-P1 zeolite) with used motor oil (1 wt %–8 wt %) caused marked changes in the aggregates’ microstructure, measured by a combination of mercury porosimetry (MIP), microtomography (MT), and scanning electron microscopy. Maximum porosity was produced at low (1%–2%) oil concentrations and it dropped at higher concentrations, opposite to the aggregates’ bulk density. Average pore radii, measured by MIP, decreased with an increasing oil concentration, whereas larger (MT) pore sizes tended to increase. Fractal dimension, derived from MIP data, changed similarly to the MIP pore radius, while that derived from MT remained unaltered. Solid phase density, measured by helium pycnometry, initially dropped slightly and then increased with the amount of oil added, which was most probably connected to changes in the formation of extremely small closed pores that were not available for He atoms.
Optimization of High Temperature and Pressurized Steam Modified Wood Fibers for High-Density Polyethylene Matrix Composites Using the Orthogonal Design Method
Authors: Gao Xun , Li Qingde , Cheng Wanli , Han Guangping , Xuan Lihui
Published: October 2016

The orthogonal design method was used to determine the optimum conditions for modifying poplar fibers through a high temperature and pressurized steam treatment for the subsequent preparation of wood fiber/high-density polyethylene (HDPE) composites. The extreme difference, variance, and significance analyses were performed to reveal the effect of the modification parameters on the mechanical properties of the prepared composites, and they yielded consistent results. The main findings indicated that the modification temperature most strongly affected the mechanical properties of the prepared composites, followed by the steam pressure. A temperature of 170 °C, a steam pressure of 0.8 MPa, and a processing time of 20 min were determined as the optimum parameters for fiber modification. Compared to the composites prepared from untreated fibers, the tensile, flexural, and impact strength of the composites prepared from modified fibers increased by 20.17%, 18.5%, and 19.3%, respectively. The effect on the properties of the composites was also investigated by scanning electron microscopy and dynamic mechanical analysis. When the temperature, steam pressure, and processing time reached the highest values, the composites exhibited the best mechanical properties, which were also well in agreement with the results of the extreme difference, variance, and significance analyses. Moreover, the crystallinity and thermal stability of the fibers and the storage modulus of the prepared composites improved; however, the hollocellulose content and the pH of the wood fibers decreased.
Cost-Efficient Wafer-Level Capping for MEMS and Imaging Sensors by Adhesive Wafer Bonding
Authors: Bleiker Simon , Visser Taklo Maaike , Lietaer Nicolas , Vogl Andreas , Bakke Thor , Niklaus Frank
Published: October 2016

Device encapsulation and packaging often constitutes a substantial part of the fabrication cost of micro electro-mechanical systems (MEMS) transducers and imaging sensor devices. In this paper, we propose a simple and cost-effective wafer-level capping method that utilizes a limited number of highly standardized process steps as well as low-cost materials. The proposed capping process is based on low-temperature adhesive wafer bonding, which ensures full complementary metal-oxide-semiconductor (CMOS) compatibility. All necessary fabrication steps for the wafer bonding, such as cavity formation and deposition of the adhesive, are performed on the capping substrate. The polymer adhesive is deposited by spray-coating on the capping wafer containing the cavities. Thus, no lithographic patterning of the polymer adhesive is needed, and material waste is minimized. Furthermore, this process does not require any additional fabrication steps on the device wafer, which lowers the process complexity and fabrication costs. We demonstrate the proposed capping method by packaging two different MEMS devices. The two MEMS devices include a vibration sensor and an acceleration switch, which employ two different electrical interconnection schemes. The experimental results show wafer-level capping with excellent bond quality due to the re-flow behavior of the polymer adhesive. No impediment to the functionality of the MEMS devices was observed, which indicates that the encapsulation does not introduce significant tensile nor compressive stresses. Thus, we present a highly versatile, robust, and cost-efficient capping method for components such as MEMS and imaging sensors.
A Review of Thermo- and Ultrasound-Responsive Polymeric Systems for Delivery of Chemotherapeutic Agents
Authors: Zardad Az-Zamakhshariy , Choonara Yahya , Du Toit Lisa , Kumar Pradeep , Mabrouk Mostafa , Kondiah Pierre , Pillay Viness
Published: October 2016

There has been an exponential increase in research into the development of thermal- and ultrasound-activated delivery systems for cancer therapy. The majority of researchers employ polymer technology that responds to environmental stimuli some of which are physiologically induced such as temperature, pH, as well as electrical impulses, which are considered as internal stimuli. External stimuli include ultrasound, light, laser, and magnetic induction. Biodegradable polymers may possess thermoresponsive and/or ultrasound-responsive properties that can complement cancer therapy through sonoporation and hyperthermia by means of High Intensity Focused Ultrasound (HIFU). Thermoresponsive and other stimuli-responsive polymers employed in drug delivery systems can be activated via ultrasound stimulation. Polyethylene oxide/polypropylene oxide co-block or triblock polymers and polymethacrylates are thermal- and pH-responsive polymer groups, respectively but both have proven to have successful activity and contribution in chemotherapy when exposed to ultrasound stimulation. This review focused on collating thermal- and ultrasound-responsive delivery systems, and combined thermo-ultrasonic responsive systems; and elaborating on the advantages, as well as shortcomings, of these systems in cancer chemotherapy. The mechanisms of these systems are explicated through their physical alteration when exposed to the corresponding stimuli. The properties they possess and the modifications that enhance the mechanism of chemotherapeutic drug delivery from systems are discussed, and the concept of pseudo-ultrasound responsive systems is introduced.
Multiresponsive Behavior of Functional Poly(p-phenylene vinylene)s in Water
Authors: Ryskulova Kanykei , Rao Gulur Srinivas Anupama , Kerr-Phillips Thomas , Peng Hui , Barker David , Travas-Sejdic Jadranka , Hoogenboom Richard
Published: October 2016

The multiresponsive behavior of functionalized water-soluble conjugated polymers (CPs) is presented with potential applications for sensors. In this study, we investigated the aqueous solubility behavior of water-soluble CPs with high photoluminescence and with a particular focus on their pH and temperature responsiveness. For this purpose, two poly(phenylene vinylene)s (PPVs)—namely 2,5-substituted PPVs bearing both carboxylic acid and methoxyoligoethylene glycol units—were investigated, with different amount of carboxylic acid units. Changes in the pH and temperature of polymer solutions led to a response in the fluorescence intensity in a pH range from 3 to 10 and for temperatures ranging from 10 to 85 °C. Additionally, it is demonstrated that the polymer with the largest number of carboxylic acid groups displays upper critical solution temperature (UCST)-like thermoresponsive behavior in the presence of a divalent ion like Ca2+. The sensing capability of these water-soluble PPVs could be utilized to design smart materials with multiresponsive behavior in biomedicine and soft materials.
Oil Droplet Clouds Suspended in the Sea: Can They Be Remotely Detected?
Authors: Otremba Zbigniew
Published: October 2016

Oil floating on the sea surface can be detected by both passive and active methods using the ultraviolet-to-microwave spectrum, whereas oil immersed below the sea surface can signal its presence only in visible light. This paper presents an optical model representing a selected case of the sea polluted by an oil suspension for a selected concentration (10 ppm) located in a layer of exemplary thickness (5 m) separated from the sea surface by an unpolluted layer (thickness 1 m). The impact of wavelength and state of the sea surface on reflectance changes is presented based on the results of Monte Carlo ray tracing. A two-wavelength index of reflectance is proposed to detect oil suspended in the water column (645–469 nm).
Scale-Aware Pansharpening Algorithm for Agricultural Fragmented Landscapes
Authors: Lillo-Saavedra Mario , Gonzalo-Martín Consuelo , García-Pedrero Angel , Lagos Octavio
Published: October 2016

Remote sensing (RS) has played an important role in extensive agricultural monitoring and management for several decades. However, the current spatial resolution of satellite imagery does not have enough definition to generalize its use in highly-fragmented agricultural landscapes, which represents a significant percentage of the world’s total cultivated surface. To characterize and analyze this type of landscape, multispectral (MS) images with high and very high spatial resolutions are required. Multi-source image fusion algorithms are normally used to improve the spatial resolution of images with a medium spatial resolution. In particular, pansharpening (PS) methods allow one to produce high-resolution MS images through a coherent integration of spatial details from a panchromatic (PAN) image with spectral information from an MS. The spectral and spatial quality of source images must be preserved to be useful in RS tasks. Different PS strategies provide different trade-offs between the spectral and the spatial quality of the fused images. Considering that agricultural landscape images contain many levels of significant structures and edges, the PS algorithms based on filtering processes must be scale-aware and able to remove different levels of detail in any input images. In this work, a new PS methodology based on a rolling guidance filter (RGF) is proposed. The main contribution of this new methodology is to produce artifact-free pansharpened images, improving the MS edges with a scale-aware approach. Three images have been used, and more than 150 experiments were carried out. An objective comparison with widely-used methodologies shows the capability of the proposed method as a powerful tool to obtain pansharpened images preserving the spatial and spectral information.
Non-Enzymatic Glucose Sensing Using Carbon Quantum Dots Decorated with Copper Oxide Nanoparticles
Authors: Maaoui Houcem , Teodoresu Florina , Wang Qian , Pan Guo-Hui , Addad Ahmed , Chtourou Radhouane , Szunerits Sabine , Boukherroub Rabah
Published: October 2016

Perturbations in glucose homeostasis is critical for human health, as hyperglycemia (defining diabetes) leads to premature death caused by macrovascular and microvascular complications. However, the simple and accurate detection of glucose in the blood at low cost remains a challenging task, although it is of great importance for the diagnosis and therapy of diabetic patients. In this work, carbon quantum dots decorated with copper oxide nanostructures (CQDs/Cu2O) are prepared by a simple hydrothermal approach, and their potential for electrochemical non-enzymatic glucose sensing is evaluated. The proposed sensor exhibits excellent electrocatalytic activity towards glucose oxidation in alkaline solutions. The glucose sensor is characterized by a wide concentration range from 6 µM to 6 mM, a sensitivity of 2.9 ± 0.2 µA·µM−1·cm−2, and a detection limit of 6 µM at a signal-to-noise ratio S/N = 3. The sensors are successfully applied for glucose determination in human serum samples, demonstrating that the CQDs/Cu2O-based glucose sensor satisfies the requirements of complex sample detection with adapted potential for therapeutic diagnostics.
Cross-Neutralisation of In Vitro Neurotoxicity of Asian and Australian Snake Neurotoxins and Venoms by Different Antivenoms
Authors: Silva Anjana , Hodgson Wayne , Isbister Geoffrey
Published: October 2016

There is limited information on the cross-neutralisation of neurotoxic venoms with antivenoms. Cross-neutralisation of the in vitro neurotoxicity of four Asian and four Australian snake venoms, four post-synaptic neurotoxins (α-bungarotoxin, α-elapitoxin-Nk2a, α-elapitoxin-Ppr1 and α-scutoxin; 100 nM) and one pre-synaptic neurotoxin (taipoxin; 100 nM) was studied with five antivenoms: Thai cobra antivenom (TCAV), death adder antivenom (DAAV), Thai neuro polyvalent antivenom (TNPAV), Indian Polyvalent antivenom (IPAV) and Australian polyvalent antivenom (APAV). The chick biventer cervicis nerve-muscle preparation was used for this study. Antivenom was added to the organ bath 20 min prior to venom. Pre- and post-synaptic neurotoxicity of Bungarus caeruleus and Bungarus fasciatus venoms was neutralised by all antivenoms except TCAV, which did not neutralise pre-synaptic activity. Post-synaptic neurotoxicity of Ophiophagus hannah was neutralised by all antivenoms, and Naja kaouthia by all antivenoms except IPAV. Pre- and post-synaptic neurotoxicity of Notechis scutatus was neutralised by all antivenoms, except TCAV, which only partially neutralised pre-synaptic activity. Pre- and post-synaptic neurotoxicity of Oxyuranus scutellatus was neutralised by TNPAV and APAV, but TCAV and IPAV only neutralised post-synaptic neurotoxicity. Post-synaptic neurotoxicity of Acanthophis antarcticus was neutralised by all antivenoms except IPAV. Pseudonaja textillis post-synaptic neurotoxicity was only neutralised by APAV. The α-neurotoxins were neutralised by TNPAV and APAV, and taipoxin by all antivenoms except IPAV. Antivenoms raised against venoms with post-synaptic neurotoxic activity (TCAV) cross-neutralised the post-synaptic activity of multiple snake venoms. Antivenoms raised against pre- and post-synaptic neurotoxic venoms (TNPAV, IPAV, APAV) cross-neutralised both activities of Asian and Australian venoms. While acknowledging the limitations of adding antivenom prior to venom in an in vitro preparation, cross-neutralization of neurotoxicity means that antivenoms from one region may be effective in other regions which do not have effective antivenoms. TCAV only neutralized post-synaptic neurotoxicity and is potentially useful in distinguishing pre-synaptic and post-synaptic effects in the chick biventer cervicis preparation.
Intestinal Organoids—Current and Future Applications
Authors: Meneses Andre , Schneeberger Kerstin , Kruitwagen Hedwig , Penning Louis , Van Steenbeek Frank , Burgener Iwan , Spee Bart
Published: October 2016

Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine.
Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation
Authors: Zhang Xiaofeng , Pham Kenny , Liu Shuai , Legris Marc , Muthengi Alex , Jasinski Jerry P , Zhang Wei
Published: October 2016

The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential aminomethylation reaction with formaldehyde through [5 + 1] annulation to afford a novel polycyclic scaffold bearing tetrahydroquinazoline, pyrrolidine, pyrrolidinedione, and N-substituted maleimide in stereoselective fashion.
ON THE CAPABILITIES OF SURVEY TELESCOPES OF MODERATE SIZE
Authors: Terebizh V. Yu.
Published: October 2016

To explore the capabilities of moderate-size optical telescopes used in surveys, a set of nine new wide-field designs, having apertures of up to 1 m, was created. The designs were optimized to ensure the widest possible field of view with an image quality better than 3″ across the field. All but one of the systems have an angular field in a range of 3.°5–10° and a flat focal surface; the field of the last system is 45° in diameter with an aperture 0.5 m and a spherical focal surface. Relations between the expected limiting magnitude, survey speed, and exposure time allow one to choose the system that is best suited for the objectives of specific observations. In particular, a single wide-field telescope with an aperture of approximately 1 m can detect objects brighter than 22.5
m
over the entire hemisphere within one night. Since the optical layouts are of practical interest, their complete descriptions are given.
THE IMPLICIT CONTRIBUTION OF SLAB MODES TO THE PERPENDICULAR DIFFUSION COEFFICIENT OF PARTICLES INTERACTING WITH TWO-COMPONENT TURBULENCE
Authors: Shalchi A.
Published: October 2016

We explore the transport of energetic particles in two-component turbulence in which the stochastic magnetic field is assumed to be a superposition of slab and two-dimensional modes. It is known that in magnetostatic slab turbulence, the motion of particles across the mean magnetic field is subdiffusive. If a two-dimensional component is added, diffusion is recovered. It was also shown before that in two-component turbulence, the slab modes do not explicitly contribute to the perpendicular diffusion coefficient. In the current paper, the implicit contribution of slab modes is explored and it is shown that this contribution leads to a reduction of the perpendicular diffusion coefficient. This effect improves the agreement between simulations and analytical theory. Furthermore, the obtained results are relevant for investigations of diffusive shock acceleration.
EVOLUTION OF INTERMEDIATE-MASS X-RAY BINARIES DRIVEN BY THE MAGNETIC BRAKING OF AP/BP STARS. I. ULTRACOMPACT X-RAY BINARIES
Authors: Chen Wen-Cong , Podsiadlowski Philipp
Published: October 2016

It is generally believed that ultracompact X-ray binaries (UCXBs) evolved from binaries consisting of a neutron star accreting from a low-mass white dwarf (WD) or helium star where mass transfer is driven by gravitational radiation. However, the standard WD evolutionary channel cannot produce the relatively long-period (40–60 minutes) UCXBs with a high time-averaged mass-transfer rate. In this work, we explore an alternative evolutionary route toward UCXBs, where the companions evolve from intermediate-mass Ap/Bp stars with an anomalously strong magnetic field (100–10,000 G). Including the magnetic braking caused by the coupling between the magnetic field and an irradiation-driven wind induced by the X-ray flux from the accreting component, we show that intermediate-mass X-ray binaries (IMXBs) can evolve into UCXBs. Using the MESA code, we have calculated evolutionary sequences for a large number of IMXBs. The simulated results indicate that, for a small wind-driving efficiency f = 10−5, the anomalous magnetic braking can drive IMXBs to an ultra-short period of 11 minutes. Comparing our simulated results with the observed parameters of 15 identified UCXBs, the anomalous magnetic braking evolutionary channel can account for the formation of seven and eight sources with f = 10−3, and 10−5, respectively. In particular, a relatively large value of f can fit three of the long-period, persistent sources with a high mass-transfer rate. Though the proportion of Ap/Bp stars in intermediate-mass stars is only 5%, the lifetime of the UCXB phase is ≳2 Gyr, producing a relatively high number of observable systems, making this an alternative evolutionary channel for the formation of UCXBs.
RELATIONSHIP BETWEEN DISTRIBUTION OF MAGNETIC DECAY INDEX AND FILAMENT ERUPTIONS
Authors: Li H. , Liu Y. , Elmhamdi A. , Kordi A.-S.
Published: October 2016

The decay index n of a horizontal magnetic field is considered to be an important parameter in judging the stability of a flux rope. However, the spatial distribution of this parameter has not been extensively explored so far. In this paper, we present a delineative study of the three-dimensional maps of n for two eruptive events, in which filaments underwent asymmetrical eruptions. The corresponding n-distributions are both found to show that the filaments tend to erupt at abnormal regions (dubbed ABN regions) of n. These ABN regions appear to be divided into two subregions, with larger and smaller n. Moreover, an analysis of the magnetic topological configuration of the ABN regions has been also performed. The results indicate that these ABN regions are associated with a kind of special quasi-separatrix layer across which the connectivity of magnetic field is discontinuous. The presented observations and analyses strongly suggest that the torus instability in ABN regions may play a crucial role for the triggering of an asymmetrical eruption. Additionally, our investigation can provide a way of forecasting how a filament might erupt, and predicting the location for an asymmetrically eruptive filament to be split through analyzing the spatial structure of n.
VELOCITY VARIATIONS IN THE PHOENIX–HERMUS STAR STREAM
Authors: Carlberg R. G. , Grillmair C. J.
Published: October 2016

Measurements of velocity and density perturbations along stellar streams in the Milky Way provide a time-integrated measure of dark matter substructure at larger galactic radius than the complementary instantaneous inner-halo strong lensing detection of dark matter sub-halos in distant galaxies. An interesting case to consider is the proposed Phoenix–Hermus star stream, which is long, thin, and on a nearly circular orbit, making it a particular good target to study for velocity variations along its length. In the presence of dark matter sub-halos, the stream velocities are significantly perturbed in a manner that is readily understood with the impulse approximation. A set of simulations shows that only sub-halos above a few 107
M
⊙ lead to reasonably long-lived observationally detectable velocity variations of amplitude of order 1 km s−1, with an average of about one visible hit per (two-armed) stream over a 3 Gyr interval. An implication is that globular clusters themselves will not have a visible impact on the stream. Radial velocities have the benefit of being completely insensitive to distance errors. Distance errors scatter individual star velocities perpendicular and tangential to the mean orbit, but their mean values remain unbiased. Calculations like these help build the quantitative case to acquire large, fairly deep, precision velocity samples of stream stars.