bluuebunny/crossref_metadata_2025 huggingface dataset:
Jak2
V617F
clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk
Authors: Liu Wenli , Pircher Joachim , Schuermans Art , Ul Ain Qurrat , Zhang Zhe , Honigberg Michael C. , Yalcinkaya Mustafa , Nakao Tetsushi , Pournamadri Ashley , Xiao Tong , Hajebrahimi Mohammad Ali , Wasner Lisa , Stegner David , Petzold Tobias , Natarajan Pradeep , Massberg Steffen , Tall Alan R. , Schulz Christian , Wang Nan
Published: December 2023

JAK2 V617F (JAK2VF) clonal hematopoiesis (CH) has been associated with atherothrombotic cardiovascular disease (CVD). We assessed the impact of Jak2VF CH on arterial thrombosis and explored the underlying mechanisms. A meta-analysis of 3 large cohort studies confirmed the association of JAK2VF with CVD and with platelet counts and adjusted mean platelet volume (MPV). In mice, 20% or 1.5% Jak2VF CH accelerated arterial thrombosis and increased platelet activation. Megakaryocytes in Jak2VF CH showed elevated proplatelet formation and release, increasing prothrombogenic reticulated platelet counts. Gp1ba-Cre–mediated expression of Jak2VF in platelets (VFGp1ba) increased platelet counts to a similar level as in 20% Jak2VF CH mice while having no effect on leukocyte counts. Like Jak2VF CH mice, VFGp1ba mice showed enhanced platelet activation and accelerated arterial thrombosis. In Jak2VF CH, both Jak2VF and wild-type (WT) platelets showed increased activation, suggesting cross talk between mutant and WT platelets. Jak2VF platelets showed twofold to threefold upregulation of COX-1 and COX-2, particularly in young platelets, with elevated cPLA2 activation and thromboxane A2 production. Compared with controls, conditioned media from activated Jak2VF platelets induced greater activation of WT platelets that was reversed by a thromboxane receptor antagonist. Low-dose aspirin ameliorated carotid artery thrombosis in VFGp1ba and Jak2VF CH mice but not in WT control mice. This study shows accelerated arterial thrombosis and platelet activation in Jak2VF CH with a major role of increased reticulated Jak2VF platelets, which mediate thromboxane cross talk with WT platelets and suggests a potential beneficial effect of aspirin in JAK2VF CH.
The D ~ Sense ex-vivo viability assay application in a patient with stage IV lung adenocarcinoma: a case report
Authors: Zhang Yu , Wu Xiaoyuan , He Ping , Wu Jieyu , Gu Xia , Bendek Matyas , Ötvös Rita , Szekely Laszlo
Published: December 2023

Background

The treatment resistance is a problem for lung cancer. In this study, we used a vitro tissue culturing system to select a new therapy strategy for a patient with tyrosine kinase inhibitors (TKIs) resistance.

Case presentation

A 42-year-old male Asian patient was diagnosed with advanced lung adenocarcinoma harboring an exon 19 deletion in the epidermal growth factor receptor (EGFR) gene. The patient was treated with Gefitinib, resulting in an almost complete remission for over a year. The patient relapsed after 13 months treatment, and received four cycles of chemotherapy. At 20 months, the patient had developed multiple lung metastases and a solitary cerebellar metastasis. An EGFR T790M mutation was identified in the peripheral blood sample. Subsequent treatment with Osimertinib resulted in a complete response of the intracranial metastasis. By 33 months, the patient had developed a mediastinal tumor mass that responded well to local radiotherapy. By 39 months, an EGFR C797S cis-mutation had been identified and the patient was treated with Brigatinib and Cetuximab. By 44 months, the tumor cells from the pleural effusion had been tested for sensitivity against 30 targeted and cytostatic drugs using the D ~ Sense ex-vivo viability assay. The assay identified 8 drugs with moderate to high sensitivity. Combination therapy of Gemcitabin and Lobaplatin had resulted in disease stabilization.

Conclusions

The case showed that individualized treatment aided by D ~ Sense ex-vivo viability assay can be a viable option for patients with advanced lung adenocarcinoma with pleural effusions.
Post-Tonsillectomy Outcomes in Children with Mucopolysaccharidosis and Obstructive Sleep Apnea
Authors: Elwell Zachary , Mancuso David , Wolter Nikolaus E. , Propst Evan J. , Valdez Tulio , Scheffler Patrick
Published: December 2023

Objective

To describe the incidence of respiratory complications, postoperative hemorrhage, length of stay, and cost of care in children with mucopolysaccharidosis (MPS) undergoing adenotonsillectomy (AT).

Methods

Analysis of the 2009, 2012, and 2016 editions of the Healthcare Cost and Utilization Project Kids’ Inpatient Database (HCUP KID) identified 24,700 children who underwent AT (40 children with MPS). Demographics, respiratory complications, postoperative hemorrhage, length of stay, and total cost were compared across children with and without MPS.

Results

Children with MPS had a higher likelihood of being male ( P < 0.017). There was a higher rate of respiratory complications in children with MPS compared with children without MPS [6/40 (15%) vs. 586/24,660 (2.4%), P < 0.001], which remained significant after adjusting for sex [adjusted odds ratio 6.88 (95% CI 2.87–16.46)]. There was also a higher risk of postoperative hemorrhage [4/40 (10%) vs. 444/24,660 (1.8%), P < 0.001), with sex-adjusted odds ratio of 5.97 (95% CI 2.12–16.86). Median (IQR) length of stay was increased in children with MPS (3 days, 1–4) compared with children without MPS (1 day, 1–2, P < 0.001). There was an increase in median (IQR) charges for hospital stay in children with MPS compared with their peers [$33,016 ($23,208.50–$72,280.50 vs. $15,383 ($9937–$24,462), P < 0.001].

Conclusions

Children with MPS undergoing AT had an increased risk of respiratory complications, postoperative hemorrhage, longer length of stay, and a higher cost of treatment when compared with children without MPS. This information may help inform interventional, perioperative, and postoperative decision making.
Grey-Taguchi Approach for Optimizing FSW Parameters in Joining AA6262 and AA5083 Alloys
Authors:   Department of Mechanical Engineering, ARM College of Engineering and Technology, Maraimalainagar, Chennai 603209, Sundararaj Jeyakrishnan , Naga Swapna Sri Movva ,   Department of Mechanical Engineering, P V P Siddhartha Institute of Technology, Vijayawada, India, Peyyala Anusha ,   Department of Mechanical Engineering, P V P Siddhartha Institute of Technology, Vijayawada, India, Sivasundar Vijayakumar ,   Department of Mechanical Engineering, BVC Engineering College (Autonomous), Odalarevu 533210, Andhrapradesh, India
Published: December 2023

T his study concentrates on the friction stir welding (FSW) joining of dissimilar AA6262 and AA5083 plates. Four input parameters, namely tool rotational speed (TRS), welding speed (WSP), tool tilt angle (TTA), and pin depth (PDP) are chosen to analyze the output responses of tensile strength (UTS), hardness (HBN), and wear rate (WTR) in welding. The primary objective is to optimize the variables of the FSW process for AA6262 and AA5083 alloys using a combination of Taguchi and Grey Relational Analysis (GRA) methods, while also comprehending the correlations among process variables through the application of these two methods. Utilizing the Taguchi approach, L27 orthogonal array is constructed for conducting FSW experiments. After this, the multi-objective optimization challenge is streamlined into a single-objective optimization task by leveraging the grey relational degree. The significance and impact of the distinct variables are elucidated through the application of Analysis of Variance (ANOVA). Confirmation tests and predictive analysis are performed to validate the optimal variables, which are then compared against the acquired outcomes. The results highlight the welding speed as the paramount parameter, exerting substantial influence over the output responses of the welds in contrast to the other variables under examination. The application of the Grey-Taguchi methodology yields enhancements in Tensile Strength (245.23 MPa) and Hardness (99.2 Hv), while concurrently decreasing the Wear Rate (0.00456 m3/Nm). Furthermore, the Grey Relational Grade exhibits an advancement of 0.1312. These findings collectively signify an increased operational efficiency in the welding process, particularly for dissimilar alloys.
Effects Of Sodium Nitrite, Potassium Sorbate And α-Tocopherol On Residual Nitrite, Formations Of Biogenic Amines And N-Nitrosamines In Turkish Dry Fermented Sausage (Sucuk)
Authors:   Bolu Abant Izzet Baysal University, Faculty of Engineering, Food Engineering Department, Golkoy Campus, Bolu/TURKEY, Gülsüme Bıçakcı , Ömer Eren ,   Bolu Abant Izzet Baysal University, Faculty of Engineering, Food Engineering Department, Golkoy Campus, Bolu/TURKEY
Published: December 2023

The effects of sodium nitrite, α-tocopherol and potassium sorbate on ion contents, biogenic amine (BA) and N-nitrosamine (NA) formations of Turkish type fermented sausage after storage were investigated based on Response Surface Methodology (RSM). In addition, relationships between ions, BAs and NAs were evaluated. Nitrite (NO2-) and ammonium (NH4+) ion amounts in all sausage samples were below limit of detection. The effects of factors are partially effective on the formation of nitrate (NO3-), BAs and NAs. There was a positive correlation between NO3- and N-nitrosodiethylamine (NDEA), and no correlation between other ions and BAs. The accumulations of tryptamine (TRP), tyramine (TyR) and spermidine (SPD) increased formations of NDEA, N-nitrosodi-n-propylamine (NDPA) and N-nitrosomorpholine (NMOR), respectively. It is concluded co-addition of sodium nitrite and potassium sorbate and/or α-tocopherol in fermented sausage production can significantly reduce amount of residual nitrite, thus inhibiting NAs.
Refusing the Sentimental Italian Immigration Story in Denise Giardina’s Storming Heaven
Authors: Caronia Nancy
Published: December 2023

This article examines how Denise Giardina’s award-winning novel Storming Heaven offers a counterpoint to views of early twentieth-century Italian immigration to the US that rely on assimilationist conclusions. The story of Sicilian immigrant Rosa Angelelli is embedded within the fictional retelling of West Virginia labor history known as the Mine Wars. Giardina creates a female immigrant protagonist who makes plain the abuse and trauma Italian immigrant women and girls face. This point-of-view is normally obfuscated in favor of a male immigrant’s perspective, but Rosa’s story is neither ignored nor erased. As one of four protagonists in the novel, Rosa’s fractured remembrances are told through a halting discourse, revealing her isolation and the danger that awaits her no matter the choices she makes. Taking from Loretta Baldassar and Donna Gabaccia’s ideas on personal intimacy, Rosa’s struggles are not an exception, but an object lesson in how immigrant women and girls are often left with no means to develop community or intimacy, endangering their physical, mental, emotional, and spiritual well-being.
Middletown Lives through Middle-Class Eyes: Hillbilly Elegy and the Problem with the “Liberal Media”
Authors: Zechowski Sharon
Published: December 2023

J.D. Vance does not become Senator Vance without the success of Hillbilly Elegy, his best-selling memoir (and later, film) about growing up in, and getting out of, rural Appalachia.  Initially praised by media critics for its ability to challenge middle-class assumptions about the “white working class,” the book assuaged both liberal anxiety and conservative outrage by providing demographically appropriate explanations for the election of Donald Trump.  However, the book, feature film and subsequent political campaign are also part of a much larger, lucrative culture industry built upon the commodification and fetishization of the white working class, one driven by middle-class tastes and prejudices.  This was most apparent in the promotion of the book and film by the so-called liberal media establishment, represented by the New York Times, The New Yorker, Netflix, Imagine Entertainment, HarperCollins, and Harpo Productions, to name a few.  However, the reinforcement of the false binary between liberal and conservative media obscured how the corporate media system helped elect a candidate who will work most certainly against the interests of actual working people, further alienating them from each other and a shared labor platform more generally.  Examining Hillbilly Elegy through the five filters of the Propaganda Model will help to explain the ideological and material effects of the corporate media’s agenda upon the growing class divide.
A Study of Self-Estrangement Among Fast-Food Workers
Authors: Haworth Bethany , Auerbach Daniel , Tabler Jennifer
Published: December 2023

This study examines self-estrangement, a dimension of alienation, and its attributes among fast-food service workers, while considering participant sociodemographic characteristics. A self-administered online survey, using Amazon MTURK, deployed over two time periods (N=1,513), provides data regarding our novel 12-item self-estrangement scale by fast-food occupation type (cashier, server, cook, shift manager, and general manager) and sociodemographic covariates. Preliminary analysis shows that a salaried position and those with a postbaccalaureate education experience lower levels of self-estrangement than their colleagues. Cashiers and cooks experience higher levels of self-estrangement relative to those in other positions. This study offers unique contributions to the conceptualization and operationalization of a dimension of alienation specific to self-estrangement, facilitating greater understanding of the fast-food labor sector, its organization, and the state of its workers
What does it mean to be working class? Exploring the definition of a social class identity through the eyes of working-class professional services and administrative staff in Russell Group universities
Authors: Pilgrim-Brown Jess
Published: December 2023

What it means to have a working-class identity in the UK today is constantly under tension and debate. From socio-economic proxies used by large organisations as determinants of disadvantage to POLAR data, self identification and other metrics, academic literature has largely disagreed how to measure working class as an identity over the last 20 years. This paper draws on the findings from two parts of an EdD thesis which looked to understand the experiences of working-class professional services staff in UK Higher Education. Here, it presents the findings of the literature review which discovered the multiple ways in which working class identities are determined for the purposes of research recruitment in academic papers. In the subsequent part of this paper, empirical data from interviews with working class staff in UK Higher Education looks at the facets which participants considered defined them as having a working-class identity. Moving away from traditional conceptualisation of a working-class identity as solely connected to the means of production, it suggests that a working-class identity is inherently connected to many factors in 2023, predominantly to economic disadvantage but also by occupation, social mobility discourse, and access to goods technology and entertainment. Furthermore, it finds that there are implicit features of a working-class identity shared across the study which include access to facilitating networks, narratives of luck, and being underappreciated and undervalued. This interplay between the convergence of habitus and lived experience suggests that working-class people in UK universities are subject to a lamination of field, an intersection of multiple temporalities
Preparing Working-Class Academics for Success
Authors: Oldfield Kenneth
Published: December 2023

I was one of Ryan and Sackrey’s Strangers in Paradise, an academic raised in a working-class family. After becoming a professor, I slowly grew to understand that being a successful faculty member requires learning a different set of survival techniques than those I needed to succeed in my undergraduate and graduate studies. As it was during my student years, nobody in my family or anyone they knew could counsel me on what it takes to earn tenure, promotion, sabbatical leave, or any of the other rewards the academy offers. Compounding this problem was a counterproductive belief, one frequently held by others from backgrounds like mine. Namely, the fear that asking for help shows weakness, prima facia evidence that I was unqualified to be an academic. Beyond the questions I was afraid to ask were the many questions I did not know to ask, questions with answers that would have saved me from countless headaches. In hopes of smoothing the way for recently hired working-class academics, this article presents seven lessons I wish I had learned before becoming a university professor, knowledge that had I acquired early on would have made my travels through the university labyrinth far easier – infinitely less trying.
The Man with a Million Names: A Personal Essay on Transit Work
Authors: Naiden Fred S.
Published: December 2023

This essay is a scholarly personal narrative about transit work, especially the operation of omnibuses, horse cars, trolleys, and trams in New York City in the nineteenth century. The culminating event is the trolley strike of 1895, the longest in New York history, and the theme is the need for solidarity between transit workers and the riding public, and thus for what is now is called union “Bargaining for the Public Good.” In this essay, the author speaks as both a transit worker and an historian.
Community Inequalities and Children’s Life Chances in the United States
Authors: Eppard Lawrence M. , Dalhouse Kayla , Nelson Erik , Robbins Jenna
Published: December 2023

This piece discusses the growing empirical evidence that the communities where American children spend their formative years—not just the households they are raised in but where those households are located—matter for their prospects of success in subsequent stages of their lives. The authors explore the various community characteristics—including social capital, family structure, school quality, and income—associated with educational attainment, health, teen pregnancy, social mobility, violence, crime victimization, and more.
Generating evidence on antibiotic use across human and animal health sectors using the World Health Organization’s Access, Watch, Reserve (AWaRe) classification: Exploratory pilot study in rural Pune, India
Authors: Kudale Abhay Machindra , Hiralkar Sakshi Shantanu , Sawant Pravin Arun , Hulsurkar Yogita Purushottam , Fatate Nikhil Rajkumar , Waghmare Priya Padmakar , Randive Abhishek Prakash , Phutane Mugdha Sharad , Pawar Prashant , Mhase Prashant
Published: December 2023

Background and Aim: Human antibiotic formulations in animal feed for therapeutic and non-therapeutic purposes have contributed to antimicrobial resistance worldwide; however, little evidence is available in low- and middle-income countries. We aimed to generate evidence of antibiotic use across the human and animal health sectors by investigating the overlap in antibiotic use in community settings in rural blocks of Pune District, India, following the World Health Organization’s (WHO) Access, Watch, Reserve (AWaRe) classification.

Materials and Methods: An exploratory pilot study using a cross-sectional design in two randomly selected rural blocks of the Pune district included 138 interviews with general physicians (GPs, n = 62), pharmacists (n = 60), and veterinary practitioners (n = 16) using semi-structured interview schedules and the WHO AWaRe classification. IBM-Statistical Package for the Social Sciences, Version 21.0 software was used for descriptive statistics and to calculate the proportions of the different antibiotic groups. The WHO AWaRe classification was used to describe antibiotic use by the study participants and to assess the overlap in antibiotic use.

Results: Our study provides evidence of an overlap in human and animal antibiotic use in rural community settings across the human and animal health sectors. Amoxicillin (access group), penicillin (access group), and ofloxacin (watch group) were used in both human and animal health. Amoxicillin and penicillin were used to treat common bacterial infections, ofloxacin was used to treat skin infections in humans and animals, and ofloxacin was used to treat pneumonia in animals and urinary bladder infections in humans. In contrast, azithromycin (watch group), cefixime (watch group), and amoxicillin (Access Group), with or without other antibiotics, were the most commonly used antibiotics by GPs in humans.

Conclusion: We confirmed the overlap in antibiotic use across the human and animal health sectors in rural community settings, suggesting the need for interventions following the One Health approach. Further, research is required to assess the patterns of this overlap, as well as behavior, knowledge, and potential solutions to help avoid this overlap and prevent the rampant use of antibiotics in the animal and human health sectors in rural community settings.

Keywords: antimicrobial resistance, antibiotics use, overlap, rural India, WHO AWaRe.
The Effect of RGEC on Financial Distress in Islamic Commercial Banks
Authors: Fitriana Puput , Darmawati  , Pratiwi Angrum
Published: December 2023

A bank's ability to grow depends on its ability to raise funds. If the bank does not have sufficient funds, the bank will face various risks, including liquidity risk or even financial difficulties. Businesses need to reduce the risk of financial distress and understand the elements that drive it. The purpose of this study was to examine the effect of Risk Profile, Good Coorporate Government, Earnings, and Capital (RGEC) on financial distress at Indonesian Islamic Banks. Associative descriptive quantitative methodology was used in this study. With secondary data from Islamic commercial banks in Indonesia, namely annual financial reports and GCG reports for the 2015-2020 period. Purposive sampling was used to select 9 out of 14 Islamic commercial banks in Indonesia. The independent variables are NPF, FDR, GCG, ROA, ROE, CAR, and the dependent variable is financial distress, which is calculated using the Altman Z-Score model. Using multiple linear regression analysis. The results show that NPF has a significant negative effect on financial distress, while FDR has a significant positive effect on financial distress, while GCG, ROA, ROE, and CAR have no significant effect.
Preferences for Procurement of Sharia Pay Latter Through Analysis of Factors That Influence Consumtive Behavior
Authors: Moh.Sudah
Published: December 2023

Research Aims: Find out what factors can become preferences in procuring sharia paylatter
Methodology: The research method used in this research is quantitative research. This research was tested empirically with a statistical approach using the IBM SPSS Ststistics 26 statistical test tool. The data tested was multiple linear regression to determine the results of the t test, f test and coefficient of termination test
Research Findings: From the results of the analysis, this research found that the results were variablehedonic motivation, performance expectancy, effort expectancy, facilitating conditions, price value and habit have a significant effect on consumptive behavior. Meanwhile, the social influence variable has no influence on consumptive behavior.
Theoretical Contribution: The grand theory used in this research is consumer consumptive behavior by testing seven variables. Previous research only used three to five variables. This research used 500 respondents, which was more accurate than previous research
Research limitation and implication: This research is limited to respondents who have ever used Paylatter.
Impact of the Perceived Quality of Traditional Villages’ Cultural Landscapes on Tourists’ Loyalty
Authors: SHEN Huaheng , AZIZ Nor Fadzila , HUANG Menglan , YU Lingyun
Published: December 2023

This study explored the relationship between the perceived quality of cultural landscapes and tourists’ loyalty to traditional villages using structural equation modeling (SEM) by collecting data from 463 tourists in Huangdu Dong Village within China’s Hunan Province. The results reveal that the perceived quality of traditional villages’ cultural landscapes indirectly and significantly affected tourist loyalty; its influence was primarily transmitted through the mediating variable of tourist satisfaction. Meanwhile, no significant difference in loyalty was observed between tourists’ gender, occupation, and place of residence, while age, educational background, and income level had significant effects on loyalty. This study reveals the importance of cultural landscapes in traditional village tourism and provides important ideas for traditional village tourism marketing. In doing so, this study enhances the competitiveness and influence of traditional village tourism and provides theoretical contributions to sustainable village development.
Sustainable Energy Systems and Green Hotel Practices in Hotels in Tamale Metropolis, Ghana
Authors: APPIAH Patricia Animah , ADONGO Raymond , SAFO Abdul-Rafiw
Published: December 2023

The hotel sector, along with numerous other tourism-related industries, significantly poses a threat to the environment through its extensive consumption of resources like water, energy, and non-durable items. The hotel industry is also well known for its large-scale discharge of raw and solid waste in varying proportions. As a result, numerous hotels have begun implementing innovative approaches to enhance the sustainability of their operations in efforts to alleviate their environmental impact while also addressing the increasing environmental concerns expressed by customers. Employing a cross-sectional design and quantitative approach and using both descriptive and inferential analysis, we assess sustainable energy systems and green hotel practices in the Tamale metropolis, Ghana. We find that majority of hotels in the Tamale metropolis have written green management policy. We also find that cost and customers understanding of green policies are the main challenges hindering their adaptation and implementation of sustainable energy systems. The study establishes a significant relationship between level of education and use of green energy practices. Again, the study finds staff strength to be highly inter-linked with the existence of green management policy. To this end, we recommend that operators should implement training programs for staff, replace fossil fuels with renewable energy sources and educating the citizens to foster increased awareness and trust in renewable energy systems, as well as to provide proper training for their effective utilization.
Exploring Ecological Justice in the Regulatory Framework of Land Ownership, Utilization, Control, and Inventory in Indonesia
Authors: BASUKI Agung , KARJOKO Lego , HANDAYANI I Gusti Ayu Ketut Rahmi
Published: December 2023

The aim of this study is to provide a comprehensive analysis of environmental justice elements in land inventory, tenure, ownership, use and use (IP4T) management, as described in TAP MPR IX/2001 and Government Regulation No. 16. 2004 on land administration. This study uses a standard legal research method integrating both a legal and conceptual approach. The author's study indicates that environmental justice is included in the IP4T law, as stated in TAP MPR IX/2001, as well as in Government Law No. 16 on Spatial Planning. According to Article 23 of Government Regulation No. 16/2004, IP4T maps must be taken into account for all spatial and regional planning. These maps contain more than just information on land ownership, use, and use. In addition, the IP4T dataset includes assessments of land capacity and valuation, so environmental dimensions associated with land are examined. The definition of environmental justice can be derived from Section 3, Section 5 and Section 6, Paragraph (2) of TAP MPR IX/2001. However, in practice, many inconsistencies remain and undermine basic principles of environmental justice. These irregularities are particularly widespread in the context of the implementation of IP4T (Integration Policy for Transition) within the mining industry.
Cultural Aspects of Waste Management in Poland and China
Authors: TACZKOWSKA Kalina Maria , BORKOWSKI Maciej
Published: December 2023

The main aim of this article was to present differences in the social determinants of waste management and environmental protection in Poland and People's Republic of China. A research gap was identified related to the small number of studies comparing China and Poland in the field of waste management. A systematic review of the literature on waste management and society's approach to environmental protection was conducted, with particular emphasis on municipal waste. The article uses data from local databases, i.e. the Central Statistical Office (GUS) in Poland and The Ministry of Ecology and Environment of the People's Republic of China, as well as data from the World Bank and OECD. The method of comparative analysis and Hofstede's tool were used for selected aspects of the social approach to waste management in Poland and the People's Republic of China. Empirical research was conducted in August 2023. Literature review based on key groups of social factors that differ in the analysed countries. These include those related to purity, religious beliefs, respect for nature, responsibility and ecology. Chinese citizens approach the power supply in their environment in a more collective way than in Poland. The European Union's recommendations has positively affected management of municipal waste in Poland, while in People's Republic of China legislation is constantly updated. In the authors' opinion, in subsequent studies it is worth focusing on comparing other countries in terms of their social approach to environmental protection, as well as conducting surveys.
Inflection and derivation as traditional comparative concepts
Authors: Haspelmath Martin
Published: December 2023

This article revisits the distinction between inflectional and derivational patterns in general grammar and discusses the possibility that this well-known distinction is not rooted in the reality of languages, but in the Western tradition of describing languages, through dictionaries (for words, including derived lexemes) and through grammar books (where we often find tables of exemplary paradigms). This tradition has led to rather different terminological treatments of the two kinds of patterns, but from the perspective of a constructional view of morphology, there is no need to incorporate such differences into formal grammatical descriptions. For practical purposes, we need clear and simple definitions of entrenched terms of general linguistics, so the article proposes semantically based (retro-) definitions of inflection, derivation and lexeme that cover the bulk of the existing usage. Finally, I briefly explain why we need sharp definitions of comparative concepts, and why prototype-based and fuzzy definitions of traditional terms are not helpful.
Cadmium exposure and thyroid hormone disruption: a systematic review and meta-analysis
Authors: Chung Seung Min , Chang Min Cheol
Published: December 2023

Introduction

This meta-analysis aimed to analyze the effect of cadmium (Cd) exposure on thyroid hormone disruption.

Content

Databases including PubMed, Embase, Cochrane Library, and Scopus were searched for studies published up to December 14, 2022. Studies evaluating the association between Cd exposure (blood Cd [BCd] or urine Cd [UCd]) and thyroid function (thyroid-stimulating hormone [TSH], free thyroxine [FT4], total triiodothyronine [TT3]) or thyroid autoimmunity (thyroglobulin antibody [TgAb] or thyroperoxidase Ab [TPOAb]) were included.

Summary and Outlook

This systematic review included 12 cross-sectional studies. Cd exposure showed a neutral association with TSH (pooled correlation=0.016, 95 % confidence interval [CI]=−0.013 to 0.045, p=0.277), FT4 (pooled correlation=0.028, 95 % CI=−0.005 to 0.061, p=0.098), and thyroid autoimmunity (pooled odds ratio=1.143, 95 % CI=0.820–1.591, p=0.430). However, Cd exposure showed a positive association with TT3 (pooled correlation=0.065, 95 % CI=0.050–0.080, p<0.001), which was consistent with the BCd and UCd subgroup analyses (pooled correlation=0.053 and 0.081, respectively, both p<0.001). Cd exposure was not associated with TSH, FT4, or thyroid autoimmunity but tended to increase with TT3.
Methodological tools for managing the innovative development of an educational organization
Authors:   1,2Yaroslavl State University named after. P. G. Demidova, Kashapov Mergalyas M. , Zaitsev Konstantin S. ,   1,2Yaroslavl State University named after. P. G. Demidova
Published: December 2023

The article presents a theoretical analysis of the existing tools for implementing controls in the innovative development of an educational organization. The stages of the theory of management of innovation processes, as well as the main approaches are considered. Macro, meso and microfactors of the formation of an individual learning trajectory are highlighted. The main directions of the implementation of the individual educational trajectory are determined. The features of innovative activity in the pedagogical sphere are characterized. The introduction of methodology and methodological tools in the process of introducing innovative processes in the field of education is substantiated.
Analysis of Modern Ideas About Life Satisfaction
Authors:   Novosibirsk State Pedagogical University, Kravchenko Svetlana V.
Published: December 2023

The concept of life satisfaction is undergoing a stage of rethinking and transformation in the context of scientific and psychological approaches in fundamental and applied psychology. Improvement of the quality of life, shift of values towards career and self-development, development of social networks, global warming and ecological crisis influence the needs of a modern man and give new meanings to the concept of life satisfaction. The article provides a comprehensive analysis of the concept of life satisfaction, divided into approaches based on the method of identifying key features. A current author's concept is proposed in the article, internal and external factors, their interaction with each other and their influence on the formation of overall life satisfaction are considered. It focuses on factors that are consistent with modern man, and provides an up-to-date analysis of scientific research in the context of factors and methods for assessing and measuring life satisfaction. The study is aimed at systematizing and structuring scientific knowledge to contemplate the complex and multidimensional concept of life satisfaction.
The Influence of Music on Speech Development in Children from birth to primary school age
Authors:   Novosibirsk State Pedagogical University, Suzeva Natalia A.
Published: December 2023

The article presents a theoretical analysis of the problem of the influence of music on the development of speech in children from birth to primary school age. It is noted that music occupies a special place in the correctional work on speech development in preschoolers and younger schoolchildren. The influence of musical activity on the formation of all components of a child's speech through listening to music, singing, playing musical instruments, logorhythmics and the atricalization is considered. In conclusion, it is discussed that the use of an integrative approach, including musical accompaniment in speech development classes, has a positive effect on the formation of speech activity in schoolchildren.
To the Problem of the Antinomy of Childhood, or About Necessity of “Critics of Pedagogical Reason”
Authors:   Independent Researcher, Shachina Anna Yu.
Published: December 2023

The article is devoted to the consideration of the antinomy of childhood. Its meaning lies in the need to consider childhood either as a period of life valuable in itself, or as preparation for future life. The second approach emphasizes learning a specific technique in an area of activity, while the first emphasizes self-realization and creativity. Criticism of pedagogical reason develops a methodology according to which it is not enough to consider a person from an empirical point of view; it is necessary to take into account the desire for freedom inherent in human nature. On the other hand, freedom is achievable only in cooperation and solidarity with others. Therefore, this criticism points to obstacles in the development of the pupil’s personality and warns of dangers in the structure of society if it consists of people incapable of creativity and solidarity. The conclusion from this criticism is that it is necessary to create a special psychological atmosphere in which the pupil’s personality will develop normally, and only spiritually and physically healthy people will be able to cope with the challenges of the future, which is beyond the control of educators and adults in general.
Problems Faced by Students with Intellectual Disabilities in Their Participation in Sports Education: Parent Views
Authors: AKŞİT Sevim , YILMAZ Emine Büşra , DAĞ Reyhan , ALTAN AKSU İrem , ARSLAN Semra , AKŞİT Seher , İKİZLER Hüseyin Can
Published: December 2023

Intellectual disability is a disorder that affects the child's daily social and practical skills. For this reason, unhealthy diet, sedentary lifestyle and physical movement limitation are the most common lifestyle problems in children with intellectual disabilities. Parents' opinions, attitudes, alexithymic conditions and social skill levels are effective in the participation of students with intellectual disabilities and other special needs in sports education. The aim of this research is to examine the problems encountered by students with intellectual disabilities in their participation in sports education in terms of parents' opinions. The study is based on the Socio-Ecological Model (SEM), one of the social model theories, as a theoretical framework. The research is a case study, one of the qualitative research approaches. In this research, the study group was reached by the maximum variation sampling method. Parents of children with intellectual disabilities in different cities of Turkey were included in the research in the 2021-2022 academic year. During the research process, three different study groups receiving special education and rehabilitation center, special lower class and inclusive education were studied. Data were collected by individual interview technique. The data obtained from all three groups were thematic analysis and analyzed by creating codes, categories and themes. As a result of the analysis of the data obtained, the findings were collected under four main themes in accordance with the theoretical framework. These are individual problems, social problems, problems caused by the physical environment and problems caused by politics. As a result of the research, it was determined that, according to the parents, the reason why their children with intellectual disabilities cannot participate in sports training is primarily due to problems arising from society. This situation can be evaluated within the exosystem and macro system according to SEM. Based on this model, which focuses on the individual and examines the effects on the individual, the two systems located at the outermost center have the greatest impact on individuals with intellectual disabilities.
О некоторых свойствах симметрического многочлена
Authors: Kirjackis Eduardas
Published: December 2023

There is not abstract.
The analysis of IT school examination material of 2002 year
Authors: Kaklauskas Liudas , Narkienė Vilma
Published: December 2023

In the article analyzing IT examination material of 2002 year. For this purposes providing inquest teachers of informatics and results are evaluates by using statistical methods. Results of observing show, that 43% tasks of examine conform a program and 59% themes of examine program conform ECDL scale of estimation computer skills. Variants of examine tasks are equivalent (r meaning from 0.6 to 0.84, r2 meaning from 0.36 to 0.71). Analysis content for examinematerial feel the absence of verifying a wide theoretical and practical skills.
Analysis and application of Voronoi diagram
Authors: Rupšys Petras
Published: December 2023

In this paper an algorithm for constructing Voronoi diagram is given. Efficiency of the algorithm is investigated by the Monte Carlo simulation method. The Voronoi diagram is applied in the field of forestry.
The applied model for the stochastic extremes
Authors: Borisevič Jelena , Aksomaitis Algimantas
Published: December 2023

There is not abstract.
Strength of Composite Transport and Launch Container for Rocket Launch
Authors:   Anatolii Pidhornyi Institute of Mechanical Engineering Problems of NAS of Ukraine, Avramov Kostiantyn V. , Sirenko Volodymyr M. ,   Yuzhnoye State Design Office, Zaverukha Volodymyr V. ,   Yuzhnoye State Design Office, Plankovskyy Sergiy I. ,   O. M. Beketov National University of Urban Economy in Kharkiv, Tsegelnyk Yevgen V. ,   O. M. Beketov National University of Urban Economy in Kharkiv, Kombarov Volodymyr V. ,   O. M. Beketov National University of Urban Economy in Kharkiv
Published: December 2023

A transport and launch container for launching rockets made of fiberglass is considered. The main goal of the paper is to calculate the stress state of this container and check the strength conditions. The calculation of the pressures of the combustion products is carried out for several positions of the rocket nozzle in the container. Two cases are considered for the nozzle, which is located: in the middle of the container and at the outlet of the container. The maximum values of the pressure acting on the inner side of the container are observed when the rocket nozzle exits the container. The pressure field is axisymmetric. In view of this, to approximate the pressure field, it is decomposed into a Fourier series along the longitudinal coordinate of the rocket. The stress state of the container is also axisymmetric. In addition, it is also considered for two cases of the nozzle and the container configuration. The finite element method implemented in the ANSYS software complex was used to calculate the stress state. The highest stress values are observed when the nozzle exits the container. As it follows from the finite element calculations, circumferential stresses are the greatest. The strength limit of fiberglass is used to analyze the strength of the container. As can be seen from the calculations, the container meets the strength requirements with a large margin factor.
The Influence of Mechanical Deformation Consideration on the Results of the Calculation of the Vacuum Circuit Breaker Drive Shaft
Authors:   National Technical University Kharkiv Polytechnic Institute, Baida Yevhen I. , Panteliat Mykhailo H. ,   National Technical University Kharkiv Polytechnic Institute, Kuzmin Artem O. ,   National Technical University Kharkiv Polytechnic Institute
Published: December 2023

One of the important directions of theoretical, computational and experimental research related to the improvement and development of new design elements of modern electrical devices, primarily medium voltage circuit breakers and contactors, is the study of not only electromagnetic, but also mechanical processes in these electrical devices. The paper is devoted to the creation and use of computational models for calculating mechanical forces and deformations of an absolutely rigid and real drive shaft of a medium voltage vacuum circuit breaker in static mode with the aim of quantitative comparison of the obtained numerical results. Calculation studies are performed using the finite element method. A comparative analysis of the calculation of mechanical stresses in the drive shaft of a vacuum circuit breaker in a static mode for an absolutely rigid and real shafts is carried out in this paper on the basis of the developed models. The obtained results of computer modeling are given in detail in tabular and graphic forms, including the shape of the deflection of the medium voltage vacuum circuit breaker shaft at the maximum stroke of the actuator of the electrical device under study. It has been demonstrated that the mechanical deformation of the shaft causes a decrease in contact drop and contact pressure forces, but with a correctly selected cross-section, these values are not critical and have little effect on the circuit breaker operation (about 20% and 7%, respectively). It is shown that as a result of shaft bending, additional axial forces appear in the supports, which significantly affect the choice of bearings according to the equivalent static load.
The Choice of a Rational Technology for Manufacturing the Hydrogenerators-Motors Rotor Rim
Authors:   National Aerospace University Kharkiv Aviation Institute, Makarov Pavlo M.
Published: December 2023

The object of research in the paper is the technology of manufacturing segments of the rotor rim of large hydrogenerators-motors. The subject of study is the design and geometrical state of the rotor rim during the operation of hydraulic units. The goal is to make a three-dimensional mechanical calculation of the rotor segment for the further determination of the most optimal technology for the rotor rim manufacturing. The following tasks are set: to study the peculiarities of the manufacturing technology of the rotor rim segments; to perform an analytical calculation and a three-dimensional calculation with the determination of the average values of stresses and deformations in the rotor segment. The used methods are: finite element method of mathematical modeling of the thermal stress state of nodes. The following results were obtained: a description of the two main manufacturing technologies of the rotor rim segments, namely the stamping method and the laser cutting method, was provided. The advantages and disadvantages of each technological process were analyzed, and it was determined that the laser cutting method should be used in the production of powerful small-scale hydrogenerators. Three-dimensional models of the rotor segment were developed and a three-dimensional mechanical calculation of this model was performed, as a result of which the value of the displacement of the rotor of the hydrogenerator at the nominal frequency of rotation, as well as the average values of the stresses in the spoke and the rim of the rotor, were obtained. Based on the results of calculations, it was established that significant tolerances in the manufacture of rotor segments can lead to changes in the shape of the rotor during its further operation, the appearance of additional vibrations and further affect the performance of the hydraulic unit. The scientific novelty consists in a combined approach to the estimation of the average values of stresses and deformation of the rotor rim, taking into account the technology of its manufacture, which includes elements of analytical mechanical calculation and calculation in a three-dimensional setting.