bluuebunny/crossref_metadata_2025 huggingface dataset:
Assistência de Enfermagem no cuidado ao paciente portador de Esclerose Lateral Amiotrófica
Authors: Araújo Jessica dos Santos , Abreu Wanessa Oliveira de , Silva Jorge Luiz Lima da , Santos Daiana Alves dos
Published: January 2023

Objetivo: a esclerose lateral amiotrófica (ELA) é um distúrbio neurodegenerativo que tem maior prevalência em indivíduos de cor branca do sexo masculino acima dos 50 anos, nesse sentido, o presente estudo objetiva levantar conteúdos, em ambiente virtual, sobre as contribuições de enfermagem no cuidado com o paciente acometido pela doença. Método e Materiais: trata-se de uma revisão integrativa de caráter descritivo, realizada entre 2018 e 2022. Através de buscas nas bibliotecas virtuais BVS, Lilacs, BDenf, Scielo, Google Acadêmico e Medline de artigos publicados nos últimos 5 anos. Resultados: os cuidados de enfermagem são imprescindíveis na melhoria da qualidade de vida de tais pacientes com atuação pautada em intervenções que proporcionem o conforto físico e apoio psicológico. Considerações Finais: é necessário que os enfermeiros busquem conhecimento sobre a ELA e como tal doença afeta o indivíduo, para que o cuidado prestado seja efetivo e direcionado.
Palavras-chave: Esclerose Lateral Amiotrófica; Cuidados de Enfermagem; Enfermagem.
A vivência dos alunos de graduação de enfermagem no combate a pandemia da COVID-19 e seu impacto na formação
Authors: Ferreira Rejane Eleuterio , Gonçalves Lilian Maria da Costa
Published: January 2023

A pandemia causada pela COVID-19 resultou em um forte impacto socioeconômico, educacional e político em todo o mundo. A graduação de Enfermagem sofre, então, as consequências advindas desse contexto global atual, acarretando diversas implicações para a formação profissional. Sendo assim, o estudo terá como objetivo geral: Analisar, sob a ótica dos discentes, se a aprendizagem desenvolvida em um setor que realiza testagem e diagnóstico de COVID-19 foi um diferencial na formação dos alunos de graduação em enfermagem, e como objetivos específicos: Comparar a vivência dos alunos que tiveram aula prática em um setor que realiza testagem e diagnóstico de COVID-19 com os alunos que não tiveram aula prática nesse cenário; Identificar, sob a óptica dos alunos, se houve diferença na formação, as aulas práticas no setor que realiza testagem e diagnóstico de COVID-19. Metodologia: Trata-se de um estudo descritivo e exploratório de abordagem qualitativa e sociopoética, que será realizado na Escola de Enfermagem Anna Nery da Universidade Federal do Rio de Janeiro, com alunos do curso de graduação em Enfermagem. A produção dos dados será através de entrevista utilizando-se de questionário elaborado no Google docs com perguntas aberta e fechada e grupo-pesquisador sociopoético. Os dados serão analisados por meio da análise de conteúdo de Bardin e as expressões artísticas do grupo-pesquisador serão analisadas conforme o estudo da sociopoética Viril/classificatório. A pesquisa foi aprovada no conselho de ética em pesquisa e respeitará os princípios da resolução 466/2012 e as recomendações da Carta Circular N°1 de 2021 - CONEP/CNS/MS, que apresenta orientações para procedimentos em pesquisas com qualquer etapa em ambiente virtual.
Palavras-Chave: COVID-19; Educação em Enfermagem durante a pandemia; Implicações na formação em enfermagem; Impactos causados pela pandemia COVID-19 na Educação em Enfermagem.
Vida acadêmica de estudantes de enfermagem na pandemia
Authors: Sousa Bianca Barroso de , Lima Diellison Layson dos Santos , Silva Jorge Luiz Lima da , Nunes Gustavo André Guimarães , Silva Taynara da Costa
Published: January 2023

Introdução: a transição do ensino presencial para outras estratégias de ensino interpostas de metodologias e práticas pedagógicas chamadas de Ensino Remoto (ER), exigiu adaptação de forma rápida de docentes e discentes de todo o mundo, uma forma de dar continuidade aos cursos de graduação em meio a emergência de saúde púbica e diminuir a estagnação dos cursos. Objetivo: caracterizar a vida acadêmica dos estudantes de enfermagem de uma universidade pública do estado do Maranhão, no ensino remoto em período pandêmico. Metodologia: trata-se de um estudo transversal, exploratório, descritivo, fundamentado na abordagem quantitativa. A população foi composta por 115 discentes de enfermagem que frequentavam o ensino remoto na pandemia. A coleta de dados ocorreu entre outubro e novembro de 2021 de forma online, contendo características sociodemográficas. Resultados: participaram do estudo 97 estudantes, caracterizados predominantemente pelo sexo feminino 78,36%, entre 18 a 22 anos de idade 72,17%. Dos graduandos 93,81% consideravam-se heterossexuais e 53,60% se autodeclaram da raça/cor parda, a pandemia causou redução da renda familiar de 65,98% dos participantes. Conclusão: outras investigações relacionadas a vida acadêmica de estudantes de enfermagem devem ser realizadas, pois o período pandêmico pode ter marcado esse público.
Palavras-chave: Estudantes de enfermagem; Enfermagem; Saúde Mental.
Identification of Small Inhibitors for Human Metadherin, an Oncoprotein,
through in silico Approach
Authors: Khattak Arif Ali , Ahmad Ayaz , Khattak Haider Ali , Irshad Khan Muhammad Zafar
Published: January 2023

Aims:

Cancer is a disease that takes lives of thousands of people each year. There are more than 100 different types of cancers known to man. This fatal disease is one of the leading causes of death today.

Background:

Astrocyte elevated gene-1(AEG-1)/ Metadherin (MTDH) activates multiple oncogenic signaling pathways and leads to different types of cancers. MTDH interacting with staphylococcal nuclease domain containing 1(SND1) supports the survival and growth of mammary epithelial cells under oncogenic conditions.

Objective:

Silencing MTDH or SND1 individually or disrupting their interaction compromises the tumorigenic potential of tumor-initiating cells. The aim of our present study was to investigate novel interactions of staphylococcal nuclease domain containing 1 (SND1) binding domain of AEG-1/MTDH with different lead compounds through molecular docking approach using MOE software.

Methods:

Molecular docking was done by docking the ChemBridge database against important residues of MTDH involved in interaction with SND1. After docking the whole ChemBridge database, the top 200 interactive compounds were selected based on docking scores. After applying Lipinski’s rule, all the remaining chosen compounds were studied on the basis of binding affinity, binding energy, docking score and protein-ligand interactions. Finally, 10 compounds showing multiple interactions with different amino acid residues were selected as the top interacting compounds.

Results:

Three compounds were selected for simulation studies after testing these compounds using topkat toxicity and ADMET studies. The simulation study indicated that compound 32538601 is a lead compound for inhibiting MTDH-SND1 complex formation.

Conclusion:

These novels, potent inhibitors of MTDH-SND1 complex can ultimately help us in controlling cancer up to some extent.
Comparing the Outcomes of Conventional Coronectomy and Graft Coronectomy: A Systematic Review
Authors: Almontashri Sarah M. , Aldossary Norah M. , Assyria Ali A.
Published: January 2023

Introduction:

Coronectomy is a widely accepted alternative surgical treatment modality in which only the crown of an impacted tooth is removed, leaving the roots and their associated nerve untouched. Uncertainty remains regarding whether intraoperative bone grafting of the coronectomy socket can reduce the incidence of typical postoperative procedure-related complications.

Objective:

The purpose of this literature review is to compare the outcomes of conventional coronectomy (CC) and grafted coronectomy (GC) in terms of whether adding a bone graft material after coronectomy of impacted mandibular third molars would decrease the incidence of typical complications.

Methods:

A total of 13 cases identified from electronic databases were included in this review based on their clinical relevance.

Results:

In general, there were no significant differences between conventional coronectomy and grafted coronectomy regarding the incidence of postoperative morbidities. However, grafted coronectomy with the placement of a bone graft material in the coronectomy socket could significantly decrease the incidence of root migration requiring re-operation of the exposed roots and reduce the preexisting pocket depth distal to the 2nd molar, especially in patients with mesioangular, impacted or horizontal wisdom teeth.

Conclusion:

According to the existing literature, grafted coronectomy might offer better clinical outcomes and can minimize the typical procedure-related drawbacks of conventional coronectomy while having similar surgical morbidities.
Magnitude of Tetanus Toxoid Immunization and Associated Factors among Pregnant Women in Ethiopia
Authors: Fenta Setegn Muche , Fenta Haile Mekonnen
Published: January 2023

Background:

Maternal and neonatal tetanus remains a major global health problem. Two-thirds of the cases of neonatal tetanus occur in the poorest and least developed countries, including Ethiopia.

Objective:

This study aimed to calculate the magnitude and identify associated factors of tetanus toxoid immunization among pregnant women in Ethiopia.

Methods:

The 2016 Ethiopian demographic and health survey data were accessed and used for the analysis. A total of 7193 pregnant women were included in this study. A multilevel hurdle Poisson model was conducted to identify factors associated with tetanus toxoid immunization among pregnant women.

Results And Discussion:

Only 41.6% of pregnant women had received at least two doses of tetanus vaccine, while 58.4% received less than two doses. The multilevel hurdle Poisson model showed that residence, wealth index, education level of women, occupation of women, education level of husbands, ANC, presence of mobile phones, region, frequency of listening radio and frequency of watching television were significantly associated with tetanus toxoid immunization.

Conclusion:

Tetanus toxoid immunization coverage in Ethiopia was low. The concerned governmental organization sought to resolve enumeration area variation in tetanus toxoid immunization and closely monitored its implementation. Providing quality antenatal care, enhancing women’s educational level, and involving husbands in tetanus toxoid immunization are effective strategies to increase tetanus toxoid immunization coverage. Besides, the low-income households and the rural settings should also be given special consideration.
Imbalanced Data Analysis of Adolescent Unintended Pregnancy and Pre-marital Sex using Univariate and Bivariate Random Forest
Authors: Zain Ismaini , Rumiati Agnes Tuti , Permatasari Erma Oktania , Sari Nilam Novita
Published: January 2023

Background:

Unintended pregnancy and pre-marital sex are common in adolescents due to the lack of understanding about Adolescent Sexual and Reproductive Health (ASRH), family planning, and/or birth control.

Aims:

The purpose of this study was to classify unintended pregnancy and pre-marital sex among adolescents in East Java to find the factors behind them.

Methods:

The data used in this research included women of childbearing age based on SKAP by BKKBN in 2019. This study employed SMOTE-NC as a method for handling imbalanced data and random forest as a classification method.

Results:

The result of this study showed that the most influential variable was education and domicile for unintended pregnancy and pre-marital sex, respectively.

Conclusion:

The most influential variable in the classification of unintended pregnancy and pre-marital sex was age was education and domicile for unintended pregnancy and pre-marital sex.
Reuse of Sawdust in Developing Countries in the Light of Sustainable Development Goals
Authors: Udokpoh Udeme , Nnaji Chidozie
Published: January 2023

The several furniture-making phases, from cutting to processing to polishing, produce a significant volume of sawdust of differing grades. The extraction and disposal of such waste in developing countries with no established or sustainable methods is an increasing problem, frequently posing environmental challenges. Sawdust is one of the most underused wood waste portions, with mounds dispersed around the region, detracting from its visual appeal and causing other ecological concerns. This study investigated potential applications of sawdust as it concerns sustainable development. It sought to employ an extensive systematic literature review to establish that sawdust, which is often a nuisance at sawmills, may be put to beneficial uses. Four cardinal focus areas of this study are (i) energy generation, (ii) environmental protection/pollution containment, (iii) building construction, and (iv) water treatment/supply. Specifically, the study dealt with the feasibility of energy generation from sawdust through sawdust cook stoves, briquetting, and pyrolysis; pollution containment through sawdust-derived adsorbent; affordable building construction through sawdust-based ceiling boards and particles boards; and (iv) water treatment using point of use (PoU) sawdust-clay water filter. Based on over two hundred (200) published papers consulted in this study, it was strongly established that sawdust had found successful wide application in all four thematic areas with strategic connection to the objectives of SDGs 3.0, 6.0, 7.0, 9.0, 11.0 and 12.0. This research believes that emphasis on sustainable sawdust management can help transform the over 1.5 million tonnes of sawdust waste burned or dumped indiscriminately into value-added products each year.
The Treatment Outcome of Smart Device–Based Tinnitus Retraining Therapy: Prospective Cohort Study
Authors: Suh Myung-Whan , Park Moo Kyun , Kim Yoonjoong , Kim Young Ho
Published: January 2023

Background

Tinnitus retraining therapy (TRT) is a standard treatment for tinnitus that consists of directive counseling and sound therapy. However, it is based on face-to-face education and a time-consuming protocol. Smart device–based TRT (smart-TRT) seems to have many advantages, but the efficacy of this new treatment has been questioned.

Objective

The aim of this study was to compare the efficacy between smart-TRT and conventional TRT (conv-TRT).

Methods

We recruited 84 patients with tinnitus. Results were compared between 42 patients who received smart-TRT and 42 control participants who received conv-TRT. An interactive smart pad application was used for directive counseling in the smart-TRT group. The smart pad application included detailed education on ear anatomy, the neurophysiological model of tinnitus, concept of habituation, and sound therapy. The smart-TRT was bidirectional: There were 17 multiple choice questions between each lesson as an interim check. The conv-TRT group underwent traditional person-to-person counseling. The primary outcome measure was the Tinnitus Handicap Inventory (THI), and the secondary outcome measure was assessed using a visual analogue scale (VAS).

Results

Both treatments had a significant treatment effect, which comparably improved during the first 2 months. The best improvements in THI were –23.3 (95% CI –33.1 to –13.4) points at 3 months and –16.8 (95% CI –30.8 to –2.8) points at 2 months in the smart-TRT group and conv-TRT group, respectively. The improvements on the VAS were also comparable: smart-TRT group: –1.2 to –3.3; conv-TRT: –0.7 to –1.7.

Conclusions

TRT based on smart devices can be an effective alternative for tinnitus patients. Considering the amount of time needed for person-to-person counseling, smart-TRT can be a cost-effective solution with similar treatment outcomes as conv-TRT.
Characteristics and Health Care Use of Patients Attending Virtual Walk-in Clinics in Ontario, Canada: Cross-sectional Analysis
Authors: Lapointe-Shaw Lauren , Salahub Christine , Bird Cherryl , Bhatia R Sacha , Desveaux Laura , Glazier Richard H , Hedden Lindsay , Ivers Noah M , Martin Danielle , Na Yingbo , Spithoff Sheryl , Tadrous Mina , Kiran Tara
Published: January 2023

Background

Funding changes in response to the COVID-19 pandemic supported the growth of direct-to-consumer virtual walk-in clinics in several countries. Little is known about patients who attend virtual walk-in clinics or how these clinics contribute to care continuity and subsequent health care use.

Objective

The objective of the present study was to describe the characteristics and measure the health care use of patients who attended virtual walk-in clinics compared to the general population and a subset that received any virtual family physician visit.

Methods

This was a retrospective, cross-sectional study in Ontario, Canada. Patients who had received a family physician visit at 1 of 13 selected virtual walk-in clinics from April 1 to December 31, 2020, were compared to Ontario residents who had any virtual family physician visit. The main outcome was postvisit health care use.

Results

Virtual walk-in patients (n=132,168) had fewer comorbidities and lower previous health care use than Ontarians with any virtual family physician visit. Virtual walk-in patients were also less likely to have a subsequent in-person visit with the same physician (309/132,168, 0.2% vs 704,759/6,412,304, 11%; standardized mean difference [SMD] 0.48), more likely to have a subsequent virtual visit (40,030/132,168, 30.3% vs 1,403,778/6,412,304, 21.9%; SMD 0.19), and twice as likely to have an emergency department visit within 30 days (11,003/132,168, 8.3% vs 262,509/6,412,304, 4.1%; SMD 0.18), an effect that persisted after adjustment and across urban/rural resident groups.

Conclusions

Compared to Ontarians attending any family physician virtual visit, virtual walk-in patients were less likely to have a subsequent in-person physician visit and were more likely to visit the emergency department. These findings will inform policy makers aiming to ensure the integration of virtual visits with longitudinal primary care.
The Impact of COVID-19 Lockdown on Cases of and Deaths From AIDS, Gonorrhea, Syphilis, Hepatitis B, and Hepatitis C: Interrupted Time Series Analysis
Authors: Wu Xinsheng , Zhou Xinyi , Chen Yuanyi , Zhai Ke , Sun Ruoyao , Luo Ganfeng , Lin Yi-Fan , Li Yuwei , Yang Chongguang , Zou Huachun
Published: January 2023

Background

China implemented a nationwide lockdown to contain COVID-19 from an early stage. Previous studies of the impact of COVID-19 on sexually transmitted diseases (STDs) and diseases caused by blood-borne viruses (BBVs) in China have yielded widely disparate results, and studies on deaths attributable to STDs and BBVs are scarce.

Objective

We aimed to elucidate the impact of COVID-19 lockdown on cases, deaths, and case-fatality ratios of STDs and BBVs.

Methods

We extracted monthly data on cases and deaths for AIDS, gonorrhea, syphilis, hepatitis B, and hepatitis C between January 2015 and December 2021 from the notifiable disease reporting database on the official website of the National Health Commission of China. We used descriptive statistics to summarize the number of cases and deaths and calculated incidence and case-fatality ratios before and after the implementation of a nationwide lockdown (in January 2020). We used negative binominal segmented regression models to estimate the immediate and long-term impacts of lockdown on cases, deaths, and case-fatality ratios in January 2020 and December 2021, respectively.

Results

A total of 14,800,330 cases of and 127,030 deaths from AIDS, gonorrhea, syphilis, hepatitis B, and hepatitis C were reported from January 2015 to December 2021, with an incidence of 149.11/100,000 before lockdown and 151.41/100,000 after lockdown and a case-fatality ratio of 8.21/1000 before lockdown and 9.50/1000 after lockdown. The negative binominal model showed significant decreases in January 2020 in AIDS cases (–23.4%; incidence rate ratio [IRR] 0.766, 95% CI 0.626-0.939) and deaths (–23.9%; IRR 0.761, 95% CI 0.647-0.896), gonorrhea cases (–34.3%; IRR 0.657, 95% CI 0.524-0.823), syphilis cases (–15.4%; IRR 0.846, 95% CI 0.763-0.937), hepatitis B cases (–17.5%; IRR 0.825, 95% CI 0.726-0.937), and hepatitis C cases (–19.6%; IRR 0.804, 95% CI 0.693-0.933). Gonorrhea, syphilis, and hepatitis C showed small increases in the number of deaths and case-fatality ratios in January 2020. By December 2021, the cases, deaths, and case-fatality ratios for each disease had either reached or remained below expected levels.

Conclusions

COVID-19 lockdown may have contributed to fewer reported cases of AIDS, gonorrhea, syphilis, hepatitis B, and hepatitis C and more reported deaths and case-fatality ratios of gonorrhea, syphilis, and hepatitis C in China.
A Smart System for Remote Monitoring of Patients in Palliative Care (HumanITcare Platform): Mixed Methods Study (Preprint)
Authors: Castillo Padrós Manuel Ramón , Pastor Nuria , Altarriba Paracolls Júlia , Mosquera Peña Marcelino , Pergolizzi Denise , Salvador Vergès Àngels
Published: January 2023

BACKGROUND

Due to the complexities of advanced illnesses and their treatments, it can be difficult for patients in palliative care to maintain their quality of life. Telemedicine interventions in chronic disease management engage patients in their care, provide continuous follow-up by their health care providers, identify symptoms earlier, and allow a quick response to illness-related decline.

OBJECTIVE

We aimed to detail and reflect on the design of an app and evaluate its feasibility to monitor the clinical situation of patients with advanced illnesses.

METHODS

This study used a mixed methods design using qualitative methods to inform app development and design and quantitative methods for data collection and analysis of patient evaluations. Palliative care units in 2 Spanish university hospitals (Nuestra Señora de la Candelaria in Santa Cruz de Tenerife and University Hospital Complex of Ferrol in A Coruña) carried out a literature review, designed the study protocol, and obtained approval from the Ethics Committee from June to December 2020. In addition, focus group meetings were held, and the design and technical development of the app were elaborated on and subsequently presented in the participating palliative care units. From January to March 2021, the app was made public on the App Store and Play Store, and a pilot study with patients was carried out in April to September 2021.

RESULTS

Six focus group meetings were held that included doctors, nurses, app developers, technology consultants, and sponsors. In addition, the technology consultants presented their results 3 times in the participating palliative care units to obtain feedback. After the app’s final design, it was possible to publish it on the usual servers and begin its evaluation in patients (n=60, median age 72 years). Sixty percent (n=36) of the participants were women and 40% (n=24) were men. The most prevalent advanced pathology was cancer (n=46, 76%), followed by other diseases (n=7, 12%) and amyotrophic lateral sclerosis (n=5, 8%). Seventy percent (n=42) of the patients were already in follow-up prior to the start of the study, while 30% (n=18) were included at the start of their follow-up. The information in the app was collected and entered by relatives or caregivers in 60% (n=36) of the cases. The median follow-up was 52 (IQR 14-104) days. In all, 69% (n=41) had a follow-up >30 days (10 were deceased and 9 were missing data). The use of the different sections of the app ranged from 37% (n=22) for the glycemic record to 90% (n=54) for the constipation scale). Patients and caregivers were delighted with its ease of use and usefulness.

CONCLUSIONS

Incorporating an intelligent remote patient monitoring system in clinical practice for patients in palliative care can improve access to health services and provide more information to professionals.
Studying diurnal and secular variations of the Earth's magnetic field	using data from Yangibazar magnetic observatory (Uzbekistan)
Authors: Yusupov Valizhon , Soloviev Anatoly , Sidorov Roman
Published: January 2023

The article provides information about the Yangibazar geomagnetic observatory, managed by the Institute of Seismology of the Academy of Sciences of the Republic of Uzbekistan. The results of the study of magnetic field variations at the Yangibazar magnetic-ionospheric observatory and comparison of the average annual values of the magnetic field absolute magnitude with the main magnetic field of the Earth are demonstrated. A comparison is made between the diurnal variation of the geomagnetic field for four days on June 21–24, 2021 at the Yangibazar observatory and the diurnal variation for the same period at the nearby stations and observatories Alma-Ata (Kazakhstan) and Gyulagarak (Armenia), the absolute values of the magnetic field elements recorded at the observatory in the period 2010–2021 were also studied. The conclusion is made about the expediency of deploying high-precision geomagnetic measurements that meet the international standard on the basis of the Yangibazar observatory.
BitTorrent is Apt for Geophysical Data Collection and Distribution
Authors: Kholodkov Kirill , Aleshin Igor
Published: January 2023

This article covers a nouveau idea of a way to collect and handle geophysical data with a peer-to-peer network in near real-time. The text covers a brief introduction to the cause, the technology, and the particular case of collecting data from Global Navigation Satellite System (GNSS) stations. We describe the proof-of-concept implementation that has been tested. The test was conducted with an experimental GNSS station and a data aggregation facility. In the test, original raw GNSS signal measurements were transferred to the data aggregation center and subsequently to the consumer. Our implementation utilized the BitTorrent protocol to communicate and transfer data. The solution could be used to enable the majority of data aggregation centers for fast, reliable, and transparent real-time data handling experience for the benefit of the scientific community.
Dinámicas y actuaciones del clero parroquial de San Pedro Apóstol Tejupilco Durante la independencia
Authors: Velázquez Beltrán Rosy Itzel
Published: January 2023

En el artículo se plantea explorar la dinámica del clero parroquial en el curato de Tejupilco durante el proceso de la guerra de Independencia, a través de los perfiles de algunos curas que desempeñaron el cargo de párroco, vicario o coadjutor en el mismo. Interesa explorar la divergencia en las categorías de posibles posturas políticas manifestadas por los ministros, la importancia que tuvieron para ambos bandos y evidenciar la ambigüedad de las fuentes dentro de un contexto local polarizado por el asedio de los bandos en pugna: insurgentes y realistas.
COST-EFFECTIVENESS ANALYSIS OF ANTIBIOTIC USAGE IN DIABETIC FOOT ULCUS PATIENTS IN DOKTER SOEKARDJO TASIKMALAYA HOSPITAL
Authors: RAHAYUNINGSIH NUR , PRATIWI ALLFI LAILLA , PEBIANSYAH ANISA
Published: January 2023

Objective: Diabetic foot ulcers is sores on the skin surface until it penetrates the skin layer caused by infection, which is require high costs for treatment. This puts a considerable burden on the patient's family, health agencies and society in general. The purpose of this study was to describe the direct medical costs and cost-effective antibiotics for diabetic foot ulcer patients at Dokter Soekardjo Tasikmalaya Hospital.
Methods: The research method is retrospectively with a purposive sampling technique. The research subjects included 24 hospitalized diabetic foot ulcer patients who received antibiotic treatment ceftriaxone with metronidazole or meropenem with metronidazole. The effectiveness of therapy was determined by the Length of Stay (LOS). Direct medical costs were obtained from medical costs, treatment costs, laboratory costs, and radiology costs.
Results: The average direct medical cost for the combination of ceftriaxone and metronidazole antibiotics was Rp. 4 668 062 and for the combination of meropenem antibiotics with metronidazole was Rp. 9 093 830. The effectiveness of the antibiotic ceftriaxone with metronidazole was 47%.
Conclusion: The cost-effective antibiotic was ceftriaxone with metronidazole which has the lowest ACER value Rp. 9 932 046 and the ICER value is Rp. 22 128 840.
THE EFFECT OF OLIVE OIL, TWEEN 60 AND SPAN 20 ON PHYSICAL CHARACTERISTICS OF QUERCETIN NANOEMULGEL
Authors: CHRISMAURIN FETIANA , DWIASTUTI RINI , CHABIB LUTFI , YULIANI SRI HARTATI
Published: January 2023

Objective: This research aims to evaluate the effect of olive oil, tween 60, and span 20 on the physical properties of quercetin nanoemulgel. Methods: In this research, quercetin was formulated into nanoemulgel using a variation of olive oil, tween 60, span 20, and sodium alginate as a gelling agent. The nanoemulgel physical properties (pH, viscosity, and spreadability), stability, and particle size were tested. The data were measured and evaluated using Minitab®18 software; if the p-value<0.05, it is stated that there is a statistically significant difference in the formula. Results: The result showed that tween 60 has the greatest significant impact on pH, viscosity, and transmittance value with a p-value<0.05 for all, meanwhile span 20 has the greatest significant impact on the spreadability of the nanoemulgel preparations with a p-value<0.05 indicating that they are significantly different. Conclusion: This study reported that the effect of olive oil, tween 60 and span 20, with different variations, significantly impacts the physical properties (pH, viscosity, and spreadability) of the nanoemulgel.
IDENTIFICATION AND IN SILICO ANALYSIS OF INHIBITOR ON THE WNT/β-CATENIN SIGNALING PATHWAY AS POTENTIAL DRUG FOR COLON CANCER
Authors: RIDWAN SALBIAH , ERLINA LINDA , BAHTIAR ANTON , SUKMAWATI DEWI
Published: January 2023

Objective: We aimed to predict the PPI network and in silico analysis of a drug that can potentially inhibit colon cancer, specifically in the Wnt/β-catenin signaling pathway, based on pharmacophore modeling and molecular docking.
Methods: Target genes involved in colon development were screened for specific genes in the Wnt/b-catenin signaling pathway. Tissue construction and possible signaling pathways were analyzed using protein-protein interactions. Genes with significant centrality and best-grade values ​​were made to feature pharmacophore models and their suitability for potential drugs. Validation was carried out using the molecular docking method for interaction with the best Hits.
Results: Protein-Protein Interaction Network (PPI) revealed BTNNB1, TP53, AXIN, FZD-8, and CDK1 as potential critical targets in the Wnt/β-catenin signaling pathway and from the suitability of pharmacophore features obtained 27 drugs as the best Hit compounds. The therapeutic effects of the drugs we found were shown to be related to the synergistic activity (multitarget and multi-path). GO enrichment analysis revealed 36 GO entries, including 11 biological processes, 10 cellular components, and 15 molecular functions. Molecular docking experiments confirmed the correlation between three drugs (Clofazimine, Closantel, and Sulindac) with the best binding to 4 target proteins (AXIN1, TP53, CDK1, and FZD-8).
Conclusion: In this study, we found a potent drug that can inhibit colon cancer disease in the Wnt/β-catenin signaling pathway and an essential target protein responsible for the efficacy of colon cancer treatment, providing a theoretical basis for further research.
DEVELOPMENT OF A PREDICTION TOOL FOR THE ASSESSMENT OF RISKS ASSOCIATED WITH ACENOCOUMAROL
Authors: SIVAKUMAR V. , S. SOWMIKA , A. MADHUMITHA , KUMAR N. GOWTHAM , C. P. ANAS
Published: January 2023

Objective: To develop a statistical predictive model to ensure the safest use of oral anticoagulant (Acenocoumarol) therapy.
Methods: It is a retrospective observational single-center study done at PSG Hospitals in Coimbatore, Tamilnadu, India. The data were collected from 2019 to 2020 from Hospital Information System (HIS). The statistical analysis was done using Chi-square and Multinomial logistic regression.
Results: The study includes 82 patients who were treated with Acenocoumarol. The results were calculated using a student t-test and the P-value was<0.0001, which is significant as it is less than 0.05, and the prediction tool is developed by using Multinomial Logistic Regression.
Conclusion: The Risk Assessment tool was developed. As the sample size increases, the accuracy of predictability also increases. So further validation of the tool is required for more accuracy and the data input should also be increased.
CASE SERIES OF EMERGING NOSOCOMIAL MULTIPLE DRUG RESISTANT PATHOGEN PROVIDENCIA RETTGERI CAUSING URINARY TRACT INFECTION
Authors: MAHAJAN MAYURI , S. PRASANNA , DAS NIKUNJA KUMAR , MAHAJAN NIKHIL
Published: January 2023

We report Case Series of Emerging Nosocomial Multiple Drug Resistant Pathogen Providencia rettgeri causing Urinary Tract Infections. The most common cause of catheter-associated urinary tract infections (CAUTI), especially with long-term indwelling urinary catheters in elders, are P. rettgeri and P. stuartii. We are reporting 4 cases of UTI, which are hospital-acquired and CAUTI. These cases are admitted to MICU for treatment purposes and later develop fever spikes after a few days and are evaluated and urine culture showed multi-drug-resistant Providencia rettgeri by VITEK. The empirical therapy was discontinued, managed with fosfomycin, and discharged later with follow-up. The various reports showed P. rettgeriis susceptible for amikacin, gentamicin, tobramycin and ciprofloxacin. In our case series, we isolated multi-drug-resistant strains of P. rettgeri that showed resistance to piperacillin-tazobactam, cefuroxime, ceftriaxone, cefepime, ertapenem, imipenem, meropenem, gentamicin, tobramycin, ciprofloxacin, tigecycline, amikacin, colistin and sensitive only to fosfomycin. The significance of P. rettgeri in association with catheter-related bloodstream infections (CRBSI) and catheter-associated urinary tract infections (CAUTI) was unclear. Hence isolation of Providencia species twice from the clinical samples was considered for association with catheter infections. The proper selection of empirical antimicrobials, antibiotic sensitivity testing, avoiding misuse of antibiotics and implementing proper drug holiday and local antibiotic policy are considered appropriate combination protocol for managing emerging multi-drug-resistant nosocomial Providencia rettgeri strains.
The Protean Masculine: A Study of the Male Characters in Selected Short Stories of Damodar Mauzzo’s The Wait and Other Stories
Authors: Nigam Dr. Ruchi
Published: January 2023

Studying the female, the feminine and the feminist has been a part of literature for quite some time now but the study of men, male and masculinities is a novel field in literature which is gaining popularity lately. The idea of masculinity studies is to provide a firm platform to the masculine and male ideologies that have been relegated to the back owing to the ever-increasing feminist studies and prevalence of feminist ideologies in the field of literature. Just like the female identity, masculinity or masculine identity is a construct and mostly a probe into studies of men and male principles. Such studies reflect that masculine representations in literature are now open to ideas of alternative masculinities that do not essentially reinforce the existing patriarchal image. The fictional world sends out ideas about the existence of the protean nature of masculine and the male. It can be understood that the male identity is not restricted to the patriarchal masculine but branches into other forms like romantic masculine, lustful masculine, new masculine, and cathectic masculine. The current paper explores this concept of alternative masculinities and the protean nature of the male and the masculine as reflected in the works of Damodar Mauzzo, a Goan writer. His short story collection The Wait and Other Stories presents a gamut of male characters who represent alternative masculinities ranging from patriarchal to the egalitarian.
A Theoretical and Empirical Studies on the High-quality Development of China's Economy
Authors: Fengze Yu
Published: January 2023

Following the establishment of New China, China's economy quickly recovered from the post-war period, particularly after reform and opening up. China's economy has ushered in a 40-year period of rapid growth, with the report of the 19th National Congress in 2017 stating that "China's economy has shifted from a stage of rapid growth to a stage of high-quality development." The article first reviews and summarizes previous studies on high-quality economic development by domestic and foreign scholars to provide a reference for this study; second, it conducts a theoretical study on the definition of high-quality economic development through two perspectives of political science to clarify the economic definition and measurement method of high-quality economic development and to test the objective facts of high-quality economic development. Third, a comprehensive evaluation system for high-quality economic development was constructed through 16 indicators in four parts: economic structure, social security, environmental protection, and institutional construction. Fourth, scientific experiments were carried out using the double difference method to verify that "China's economy has shifted from the stage of high-speed growth to the stage of high-quality development," reflecting the obvious development transformation.
PROPOSIÇÃO DE UMA METODOLOGIA DE AVALIAÇÃO HIDROSSEDIMENTOLÓGICA E DE SENSIBILIDADE DE PARÂMETROS ATRAVÉS DO MODELO SWAT
Authors: Nunes Francisco Miqueias S. , Srinivasan Vajapeyam S. , Aragão Ricardo de , Brito Yáscara Maia Araújo de
Published: January 2023

Muitos problemas ambientais, principalmente na região nordeste do Brasil, são consequência direta das frequentes secas e contaminação dos mananciais nessas regiões, bem como da crescente demanda por recursos hídricos registrada nas últimas décadas. As atividades humanas têm causado diversas mudanças em bacias hidrográficas e ambientes, levando a mudanças no clima e na hidrologia. As mudanças no uso e ocupação do solo afetam o comportamento do escoamento superficial. Este trabalho tem por objetivo desenvolver uma metodologia para quantificar o escoamento superficial e a erosão do solo, relacionados à produção de sedimentos em uma bacia semiárida, levando em conta as variações nas condições do uso do solo e as variações na pluviosidade quando não existem dados fluviométricos. Portanto, o modelo SWAT (Soil and Water Assessment Tool) é utilizado como ferramenta para essas avaliações. Este estudo avaliou a Bacia do Rio Sucuru a jusante da Barragem de Sumé usando dados de precipitação, temperatura e mapas de tipo de solo, uso e ocupação do solo e mudanças observadas durante esse período, de 1994 a 2015. De acordo com a série pluviométrica utilizada para a simulação, 8 dos 22 anos de análise tiveram precipitação anual abaixo da média histórica, com 500 mm na região do Cariri da Paraíba. Por outro lado, 7 anos apresenta um total anual acentuado em torno da média. Os parâmetros mais sensíveis do modelo são aqueles relacionados às propriedades físicas e ao manejo do solo, como a capacidade de água disponível.
Estimation Methods of the Parameters in Fuzzy Pareto Distribution
Authors: Bhavana Pullooru , Priya Dr. D Kalpana
Published: January 2023

Abstract: In this paper considered the estimation of the parameters in the Fuzzy Pareto Distribution of two parameters. Now we used the Method of moments, Method of Maximum likelihood, and Method of least squares. From this it seemed to establish the consistent parameters when the sample size is increased. This paper aims at sample size increased when the parameters are consistent.
Análisis de las propiedades físicas y mecánicas del residuo de caucho de neumático como reemplazo parcial del agregado fino en el hormigón
Authors: Fernandez-Torrez Luz Adriana , Aquino-Rocha Joaquin Humberto , Cayo-Chileno Nahúm Gamalier
Published: January 2023

The objective of this study is to evaluate the physical and mechanical properties of concrete with waste tire rubber (WTR) as a partial substitute for sand, considering local materials from the city of Cochabamba, Bolivia, to promote a circular economy. The sand was replaced by WTR (in volume) in four percentages: 0% (reference), 5%, 10%, and 20%, evaluating its mechanical properties (resistance to compression, traction, and bending) and physical properties (specific mass, water absorption, and void index). The results indicate that there is a tendency to decrease with a higher percentage of WTR, both for mechanical resistance and for physical properties, except for the mixture with 5% WTR, which had results comparable to concrete with natural sand. WTR can be used in the local production of concrete up to 5% without compromising its mechanical and physical properties, in addition to having a sustainable approach.
Aprovechamiento y presentación de potencialidades sostenibles en el modelo de movilidad urbana del centro de la ciudad de Ambato
Authors: Goyes-Balladares Andrea Cristina , Moya-Jiménez Roberto Carlos
Published: January 2023

The intensified urbanization process of recent decades has highlighted the need to plan cities, suitably considering people’s mobility. The goal of this article is to analyze the mobility conditions of Ambato city center using a sustainability approach. The methodology used was based on a theoretical review and analysis of official documents, fieldwork, and observation records. The results were obtained by analyzing objective and technical variables that show the study area’s potentialities and weaknesses to develop active and less polluting modes of transport. A reflection on the characteristics of pedestrians, cyclists, and mass public transport is presented to propose management strategies that aim at strengthening the current mobility model.
Digital Literacy and Primary Educational System in Benin City, Edo State, Nigeria
Authors: Imhanyehor Germaine O. J.
Published: January 2023

Despite the enormous potential of ICTs and digital literacy in the educational setup, most primary schools in Benin City are yet to fully implement and take advantage of its numerous benefits to the teaching and learning process. This study therefore examined the possibility of incorporating digital literacy at the primary school level, as well as ascertains the extent to which electronic gadgets are available and accessible and the challenges militating against the implementation of digital literacy in private primary schools in Benin City. The research design adopted for this study is descriptive survey. Using the stratified random sampling technique, a total of 448 primary school teachers responded to the Digital Literacy Questionnaire in Primary School (DLPQS) that was developed by the researcher and used for data collection. The data analysis was done using simple tables of frequency counts and percentages. Findings from the study revealed that whilst 90.2 % of the teachers possessed Personal Computers (PC) and other electronic gadgets and were relatively proficient with the use of said devices, computers and digital gadgets were not readily available and accessible as 52.7 % of the teachers taught in schools that did not currently have a computer lab with 60.7 % not having access to the lab. Where available, 69.4 % of the teachers indicated that most of the computers where outdated and not functional and 79.5 % reported that the number of computers were insufficient. Findings also showed that – lack of/insufficient number of computers, poor internet connectivity and epileptic power supply were the major drawbacks in the use of digital literacy in the primary schools.
New Tendencies in Operational Risk Management in Banks: Challenges and Opportunities
Authors: Sobanova Jelena , Kudinska Marina
Published: January 2023

The importance of operational risk management in the bank increases every year. Banks need to take actions to prevent fraudulent activities, minimize errors in transactions, automate processes and improve data security. Ignoring operational risk procedures or failure to implement suitable control mechanisms could lead to unexpected losses, unsatisfied customers, and potentially regulatory sanctions, all of which could seriously harm bank’s reputation in a highly competitive market. A specific focus is on payments and security transactions, as they are linked to the biggest risks. Any regulatory driven project failure or IT project failure in the bank, insufficient project governance, failed implementation of a new system or failure in external data sources can lead to even bigger losses. After a review of the Basel Framework and the new set of standards of the upcoming changes to take effect as of 2023, the aim of this article is to elucidate the changes related to operational risk capital in banks and to ascertain the weakest points in operational risk management. Therefore, this topic is timely relevant, as the aim of the research is to manifest the possible changes withing operational risk management in banks, by gathering and analysing empirical evidence. This article is based on academic research and professional experience. The methods used in the research are comparison, generalization and graphical illustration of statistical information, identification of the main idea of regulatory frameworks and legal documentation. The main results and findings of the research are that banks will need to rethink the strategies of their capital management and this article emphasizes the importance of a redesigned approach towards operational risk assessment in Basel III and substantiates the efficiency of the proposed framework. With Basel III, each loss may cause more challenges, as will be considered twice, as the direct impact on profit/loss and direct impact on future operational risk capital. Another finding is that the biggest amounts of losses are related to corporate items events and according to the static data taken from ORX membership community, top five monthly losses are far from normal distribution. Important finding was that most of the banks were not prepared for COVID-19-pandemic and had to review operational risk procedures immediately to secure their business in working from home environment, meaning that gap in operational risk management existed already before COVID-19-pandemic.
Evaluasi Kesesuaian Lahan Untuk Pengembangan Komoditas Lada di Kabupaten Tanjung Jabung Timur
Authors: Firdaus Firdaus , Hendri Jon , Saidi Busyra B
Published: January 2023

Lada (Piper nigrum L.) merupakan salah satu komoditas unggulan dari sektor perkebunan. memiliki potensi besar dalam pertumbuhan ekonomi Indonesia karena mempunyai kontribusi terhadap devisa Negara. Lada merupakan komoditas ekspor potensial di Indonesia. Adanya ekspor lada Indonesia di pasar global akan meningkatkan devisa Negara dan menggerakkan perekonomian dalam negeri khususnya produsen atau petani lada, karena 96% perkebunan lada di Indonesia merupakan perkebunan rakyat. Pengembangan tanaman perkebunan baik secara kualitas maupun kuantitas masih sangat dimungkinkan. Peluang tertuju pada pengembangan pertanian di wilayah sub optimal (lahan rawa pasang surut), karena potensi lahan cukup luas. Tanjung Jabung Timur merupakan wilayah pasang surut yang potensial untuk pengembangan tanaman Lada. Tujuan penelitian adalah untuk mengetahui kesesuaian lahan untuk pengembangan lada di Kabupaten Tanjung Jabung Timur Provinsi Jambi. Penelitian ini menggunakan metode deskriptif kualitatif. Dari hasil penelitian diperoleh kelas kesesuaian lahan untuk tanaman lada di Kabupaten Tanjung Jabung Timur umumnya sesuai marginal (S3). Seluas 304.226 ha (61,64%) wilayah dengan factor pembatas; pH kecil dari 4,8 dan 4,0, drainase terhambat, kedalaman bahan sulfidik 40-75 cm. Seluas 183.352 ha (37,14%) lahan tidak sesuai (N), dengan factor pembatas; drainase sangat terhambat, ketebalan gambut 200-300 cm, dan kedalaman bahan Sulfidik kurang dari 40 cm. Berdasarkan faktor pembatas untuk pengembangan Lada di Tanjung Jabung Timur, maka teknologi yang diperlukan adalah; ameliorasi lahan dengan pemberian kapur dan bahan organik untuk meningkatkan kemampuan retensi hara, pemupukan lengkap untuk meningkatkan ketersediaan hara, pengaturan sistem tata air tanah dan tinggi permukaan air tanah harus di atas lapisan bahan sulfidik.