bluuebunny/crossref_metadata_2025 huggingface dataset:
Orgány vyšetřování protistátní trestné činnosti vojenských osob po roce 1948
Authors: Polnar Stanislav
Published: December 2021

Since the end of World War II, the investigation of anti-state delinquency of military personnel was realised by the military intelligence. It originated with Czechoslovak military units in the USSR and were influenced by Soviet security authorities. After 1945 and 1948 these bodies remained in the structure of the Ministry of National Defense, but from the beginning of the 1951 they moved to the structure of the Ministry of the Interior following the Soviet model. The legal status of these bodies was always unclear and did not correspond to the legal regulation. Another important article in the investigation of the political delinquency of soldiers was the military prosecutor’s office as part of the socialist-type prosecutor’s office, which was subjected to general trends in the regulation of criminal proceedings.
Urážka prezidenta republiky po roce 1945 až do současnosti
Authors: Vetešník Pavel
Published: December 2021

The article deals with the definition of the legal regulation of insult of the President of the Republic and its punishment in the territory of the Czech Republic after 1945 up to the present. Due to the fact that such a definition has not always been made exclusively by legislation of a criminal law nature, the contribution will also focus on legislation of an administrative and private nature. During the elaboration of the contribution, mainly explanatory memoranda to the laws that introduced, changed or deleted the legal regulation of insulting the President of the Republic will be drawn. Periodical comments explaining the individual starting points of these legal regulations and related case law will also be a necessary helper. This will show an overall view of the legal regulation of insults of the President of the Republic in the period under review.
The Right to Family Life in the Case Law of the European Court of Human Rights
Authors: Kotková Petra , Palásek Milan
Published: December 2021

The paper deals with the case law of the European Court of Human Rights relating to cohabitation and other law aspects with this institute related. Attention will be focused particularly to clarification of cohabitation in relationship of marriage or relationship of same-sex couples, especially in connection with Art. 8 and 14 of the Convention.
National Survey on the importance of sleep in the quality of academic life and mental health of college students in Portugal
Authors: Reis Marta , Ramiro Lúcia , Paiva Teresa , Gaspar-de-Matos Margarida
Published: December 2021

The academic years are a period of vulnerability when considering sleep problems and mental health. Growing evidence suggests poor sleep patterns are related to impaired academic life and lower psychological well-being. The aim of this study was to explore the importance of sleep habits and report the associations of sleep problems with quality of academic life and different dimensions of mental health (e.g. worries, anxiety, self-regulation and resilience) in a large sample of college students. The HBSC/JUnP data base comprises a representative sample of 2991 college students (n=2203; 73.7% women), aged from 18 to 35 years old (22.43±3.83). Participants socio-demographic characteristics included sex and age. Besides, participants were inquired about sleep duration, characteristics of their sleep habits, questions about quality academic life, namely feeling bored in university, pressure from academic work and academic performance perception and mental health, namely worries, anxiety, self-regulation and resilience. Results showed most young people report an average value for sleep habits (M=4.41; SD=1.46) and that they sleep an average of 7 hours a night. More than half of the young people report either being affected by difficulty falling asleep, showing signs of sleep onset insomnia (67.7%). The conducted analyses indicated that the difficulty falling asleep (having insomnia) was associated with poor/reasonable academic performance perception, higher levels of concerns and anxiety, and lower levels of self-regulation and resilience, thus jeopardizing the mental health of college students. In turn, that characteristics of sleep was also associated with poor sleep habits. In conclusion, this study showed that poor sleep habits were associated with a worse level of academic performance perception and low levels of mental health among college students in Portugal. Universities offer enormous potential as settings to promote sleep-health programs since they can reach many young people who are future-oriented and willing to learn. There is then the need for academic researchers, teaching staff and health professionals working for college students health, to develop and test a wide array of sleep-promoting interventions (e.g., education classes, online programs, adjustment of class time), thus preventing negative secondary outcomes.
Self-control or social control - what determines sleep hygiene in bed-sharing couples?
Authors: Drews Henning Johannes , Göder Robert , Mitkidis Panagiotis
Published: December 2021

Objectives: To investigate intimate partners’ impact on sleep hygiene with focus on the temporal dimension and differential predictors of sleep hygiene in co-sleepers and individual sleepers.

Material and Methods: Habitual co-sleepers and individual sleepers (n=102) completed a cross-sectional, self-report, in-lab, digital survey on sleep hygiene, habitual sleeping arrangement, self-control, depressiveness, and sociodemographic parameters.

Results: The relationship between sleeping arrangement and sleep hygiene in co-sleepers was time-dependent with an initial steep incline and a subsequent plateau at approximately one year of co-sleeping routine. Co-sleepers with more than one year of unaltered sleeping arrangement had significantly better sleep hygiene than co-sleepers with less than one-year or individual sleepers. More than one-year continuity of the sleeping arrangement moreover robustly predicted sleep hygiene in co-sleepers whereas self-control was the dominant predictor in individual sleepers.

Conclusion: Amongst others, our findings support the idea that insomnia treatment could be improved by becoming sensitive to the habitual sleeping arrangement.
How do adolescents with short sleep duration spend their extra waking hours? A device-based analysis of physical activity and sedentary behaviour in a Brazilian sample
Authors: Costa Bruno Gonçalves Galdino da , Chaput Jean-Philippe , Lopes Marcus Vinicius Veber , Malheiros Luís Eduardo Argenta , Silva Kelly Samara
Published: December 2021

Objectives: To compare sedentary behaviour and physical activity between short sleepers and adequate sleepers in a sample of Brazilian adolescents.

Material and Methods: 688 adolescents wore accelerometers on the non-dominant wrist for seven days. Sleep duration, sedentary behaviour, light (LPA), moderate (MPA), and vigorous physical activity (VPA) were estimated. Participants were classified as short (<8h/night) or adequate sleepers (≥8h/night). The minutes and the percentage of time spent in each waking behaviour was compared between short and adequate sleepers.

Results: Participants were 16.3 years old, 50.4% were female, and 67.7% were short sleepers. Adequate sleepers engaged in less (min/day) sedentary behaviour (-53.46), LPA (-25.44), MPA (-4.27), and VPA (-0.63) compared to short sleepers. However, no differences were observed for the proportion of time (68% in sedentary behaviour, 28% in LPA, 3% in MPA, and <0.4% in VPA).

Conclusion: Patterns of waking behaviours are similar between short and adequate sleepers.
Sleep pattern gender differences and fragmentation in postpartum parents of twins
Authors: Damato Elizabeth G , Burant Christopher J , Brubaker Jennifer A , Decker Michael J
Published: December 2021

Objective Parents of newborn twins are at risk for both shortened sleep duration and sleep discontinuity. The purpose of this study was to characterize weekday and weekend sleep duration, sleep continuity, and awakenings in both mothers and fathers of newborn twins during the first 3 months at home.

Material and Methods Sleep-wake parameters were assessed at two time points using self-report diaries and actigraphy in 75 families with newborn twins. To assess sleep on weekdays and weekends with minimal subject burden, actigraphy recordings of both parents commenced at 9:00 p.m. Saturday and terminated at 9:00 p.m. Tuesday.

Results Mean sleep duration over 24 hours for parents of twins ranged between 6.7 and 7.5 hours during the first 3 months postpartum and did not significantly differ on weekdays or weekends for mothers. Weekend sleep was more fragmented for fathers at both one month and three months with more awakenings, compared to weekday sleep. Mothers had more fragmented night sleep compared to fathers at one month. In contrast, at three months postpartum fathers had shorter total sleep time and night sleep time, but fewer night awakenings on weekdays than mothers. No differences were observed in weekend sleep duration or sleep patterns between mothers and fathers at three months.

Discussion Consolidated sleep periods for both parents averages three hours or less during the first three months postpartum and sleep for both parents is fragmented. In families with newborn twins, the extent of sleep disruption for mothers and fathers is similar.
Videogames como conteúdo? Contribuições para uma proposta de ensino baseada na pedagogia dos multiletramentos
Authors: Cruz Junior Gilson
Published: December 2021

Este ensaio tem como objetivo sistematizar e socializar as contribuições para uma proposta de ensino de jogos digitais alicerçada na pedagogia dos multiletramentos. Trata-se de uma reflexão teórica que se baseia na bibliografia pertencente ao campo de investigação dos videogames. Como resultado, descrevem-se os processos de conhecimento e as atividades de aprendizagem com base na prática situada, na instrução explícita, no enquadramento crítico e na prática transformada. Por fim, evidencia-se a compatibilidade entre as orientações pedagógicas dos multiletramentos e os jogos digitais como domínio semiótico.
Resenha do livro “Trilhas, roteiros e legendas de uma cidade chamada Duque de Caxias: memórias e representações de Francisco Barboza Leite (1950-1990)”
Authors: Laurentino Eliana
Published: December 2021

ALMEIDA, Tania Maria da Silva Amaro de. Trilhas, roteiros e legendas de uma cidade chamada Duque de Caxias: memórias e representações de Francisco Barboza Leite (1950-1990). Duque de Caxias: ASAMIH, 2019. 356p.
Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology
Authors: Ganti Apar Kishor P. , Loo Billy W. , Bassetti Michael , Blakely Collin , Chiang Anne , D'Amico Thomas A. , D'Avella Christopher , Dowlati Afshin , Downey Robert J. , Edelman Martin , Florsheim Charles , Gold Kathryn A. , Goldman Jonathan W. , Grecula John C. , Hann Christine , Iams Wade , Iyengar Puneeth , Kelly Karen , Khalil Maya , Koczywas Marianna , Merritt Robert E. , Mohindra Nisha , Molina Julian , Moran Cesar , Pokharel Saraswati , Puri Sonam , Qin Angel , Rusthoven Chad , Sands Jacob , Santana-Davila Rafael , Shafique Michael , Waqar Saiama N. , Gregory Kristina M. , Hughes Miranda
Published: December 2021

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Small Cell Lung Cancer (SCLC) provide recommended management for patients with SCLC, including diagnosis, primary treatment, surveillance for relapse, and subsequent treatment. This selection for the journal focuses on metastatic (known as extensive-stage) SCLC, which is more common than limited-stage SCLC. Systemic therapy alone can palliate symptoms and prolong survival in most patients with extensive-stage disease. Smoking cessation counseling and intervention should be strongly promoted in patients with SCLC and other high-grade neuroendocrine carcinomas. The “Summary of the Guidelines Updates” section in the SCLC algorithm outlines the most recent revisions for the 2022 update, which are described in greater detail in this revised Discussion text.
NCCN Guidelines® Insights: Squamous Cell Skin Cancer, Version 1.2022
Authors: Schmults Chrysalyne D. , Blitzblau Rachel , Aasi Sumaira Z. , Alam Murad , Andersen James S. , Baumann Brian C. , Bordeaux Jeremy , Chen Pei-Ling , Chin Robert , Contreras Carlo M. , DiMaio Dominick , Donigan Jessica M. , Farma Jeffrey M. , Ghosh Karthik , Grekin Roy C. , Harms Kelly , Ho Alan L. , Holder Ashley , Lukens John Nicholas , Medina Theresa , Nehal Kishwer S. , Nghiem Paul , Park Soo , Patel Tejesh , Puzanov Igor , Scott Jeffrey , Sekulic Aleksandar , Shaha Ashok R. , Srivastava Divya , Stebbins William , Thomas Valencia , Xu Yaohui G. , McCullough Beth , Dwyer Mary A. , Nguyen Mai Q.
Published: December 2021

The NCCN Guidelines for Squamous Cell Skin Cancer provide recommendations for diagnostic workup, clinical stage, and treatment options for patients with cutaneous squamous cell carcinoma. The NCCN panel meets annually to discuss updates to the guidelines based on comments from panel members and the Institutional Review, as well as submissions from within NCCN and external organizations. These NCCN Guidelines Insights focus on the introduction of a new surgical recommendation terminology (peripheral and deep en face margin assessment), as well as recent updates on topical prophylaxis, immunotherapy for regional and metastatic disease, and radiation therapy.
Benefit of Postoperative Radiotherapy for Patients With Nonmetastatic Adrenocortical Carcinoma: A Population-Based Analysis
Authors: Wu Kan , Liu Xu , Liu Zhihong , Lu Yiping , Wang Xianding , Li Xiang
Published: December 2021

Background: Adrenocortical carcinoma (ACC) is an aggressive cancer with high recurrence rates and poor prognosis, even after radical surgery. The survival benefit of adjuvant radiotherapy (RT) in patients with ACC has not been well explored. The aim of this study was to evaluate the effect of adjuvant RT on the survival outcome of patients with ACC. Patients and Methods: All patients with nonmetastatic ACC who underwent complete resection were identified from the SEER database (2004–2016). Overall survival (OS) was estimated using the Kaplan-Meier method. Multivariable Cox regression analysis was performed to identify prognostic factors associated with survival. Results: Of 365 patients with nonmetastatic ACC, 55 (15.1%) received adjuvant RT and the remainder underwent surgery alone. Patient characteristics were similar between the 2 groups, but those with a higher disease stage were more likely to receive adjuvant RT. Overall, patients receiving RT seemed to have better survival compared with the non-RT group (3-year OS rate, 63.1% vs 52.8%; P<.062). After adjustment for confounding factors, adjuvant RT was indeed associated with a 48% decreased risk of death (hazard ratio, 0.52; 95% CI, 0.29–0.91; P=.023) for all patients. In addition, adjuvant RT may confer a survival benefit only in patients with a high risk of recurrence (3-year OS rate, 55.1% vs 40.0%; P=.048) rather than in those with low/moderate-risk ACC (P=.559). Conclusions: Our findings suggest that adjuvant RT may be associated with improved survival in patients with nonmetastatic ACC who underwent radical surgery, especially those with high risk of recurrence.
Integración de la tecnología digital en el aula: Diseño de una propuesta formativa online desde una mirada de la práctica reflexiva
Authors: Recio-Muñoz Francisco , Joo Nagata Jorge
Published: December 2021

Ante la necesidad de crear espacios o contextos, tanto formales como informales, que supongan una conexión real del profesorado con su entorno, es que se presenta una propuesta de experiencia de aprendizaje diseñada para la Formación Inicial Docente (FID) sobre el pensamiento reflexivo, la integración de la tecnología digital en el aula y la Competencia Digital Docente (CDD) de estudiantes de Pedagogía en Chile. Dicha propuesta se centra en los círculos de reflexión pedagógica con el objetivo principal de explorar cómo se construye la práctica reflexiva durante las interacciones en línea, concretamente en sesiones asincrónicas por medio de foros de debate, a través del análisis del discurso del contenido generado en los mismos y si resulta ser una estrategia eficaz para el desarrollo de habilidades de pensamiento reflexivo al momento de analizar las prácticas docentes entorno a la integración de las tecnologías digitales en el aula. Encontrando preliminarmente cuatro categorías a la hora de justificar por parte del alumnado sobre qué definición de reflexión más se identifican. Y aludiendo a que cuando reflexionan sobre su quehacer docente al momento de integrar las tecnologías digitales en el aula lo hacen principalmente sobre las dimensiones del contenido y alumnado, siendo en menor medida el contexto sociopolítico.

Faced with the need to create spaces or contexts, both formal and informal, that involve a real connection between teachers and their environment, a proposal for a learning experience designed for Initial Teacher Training (ITT) on reflective thinking, integration of digital technology in the classroom and the Teaching Digital Competence (TDC) of Pedagogy students in Chile. This proposal focuses on pedagogical reflection circles with the main objective of exploring how reflective practice is built during online interactions, specifically asynchronous sessions through discussion forums, through the analysis of the discourse of the content generated in them. and if it turns out to be an effective strategy for the development of reflective thinking skills when analyzing teaching practices around the integration of digital technologies in the classroom. Preliminarily finding four categories when justifying by the students about which definition of reflection they most identify. And alluding to the fact that when they reflect on their teaching work when integrating digital technologies in the classroom, they do so mainly on the dimensions of the content and students, being to a lesser extent the socio-political context.
¿Estamos tan mal? La Educación Musical en España respecto a Alemania y Austria
Authors: Mateu-Luján Borja
Published: December 2021

El presente artículo compara la educación musical que se oferta dentro de la educación obligatoria en España, Alemania (Nordrhein-Westfalen, NRW) y Austria. Para ello, se comparan las horas dedicadas a la educación musical en cada país, los contenidos que se imparten y la formación inicial de sus docentes. Los resultados muestran cómo la educación musical española, pese a que su enseñanza es optativa, tiene un horario admisible si lo comparamos con los de Alemania (NRW) y Austria. Del mismo modo, si nos centramos en los aprendizajes curriculares, también encontramos que son similares a los de Austria tanto para la Educación Primaria como para la Secundaria. Otro aspecto por destacar es que, respecto a la formación inicial, el profesorado español y alemán (NRW) de Educación Primaria es semiespecialista en Música, a diferencia del de Austria que es generalista. Por otro lado, en Alemania (NRW) y Austria el profesorado de Educación Secundaria es especialista en dos materias, mientras que en España lo es exclusivamente en Música. En consecuencia, y a raíz del estudio que se realiza en este artículo, parece que las diferencias musicales con respecto a estos dos países podrían deberse a otros aspectos como a la menor duración de la formación inicial del profesorado español, el nivel socioeconómico de las familias o el contexto cultural.
Semantic peculiarities of diminutive forms of Spanish anthroponyms
Authors: Dolzhenkova Victoria
Published: December 2021

The subject of this research is the polemical linguistic question on the peculiarities of the semantics of proper name. The object of this research is the diminutive forms of Spanish anthroponyms, which function mainly in the colloquial discourse. Analysis is conducted on the semantic peculiarities of such diminutive forms as Paco, Pepe, Charo, Maruja from frequent Spanish anthroponyms, such as Francisco, José, Rosario, María. The analysis of practical material relies on the theoretical provisions and methods of empirical research of the Russian linguoculturologists and psycholinguists, as well as on the data of the Spanish National Institute of Statistics, materials of explanatory dictionaries of the Spanish language, and publicistic texts. The conclusion is made that the colloquial discourse is the core area of verbalization of the diminutive. It is also revealed that the semantics of diminutive forms of Spanish anthroponyms contains additional connotative elements that covey unique ethno psycholinguistic information characteristic to a single linguistic consciousness. Namely the presence of culturally determined components of meaning substantiates the transition of diminutives to the category of appellatives. This article is first to analyze the semantics of diminutive forms of Spanish anthroponyms  as separate proper names, as well as distinguish additional nuances of the  meanings of these lexical unit, which defines the scientific novelty.
“Ugric text” as a cultural phenomenon: towards articulation of the problem
Authors: Gavrilov Viktor Viktorovich
Published: December 2021

Leaning on the conceptual analysis, the article describes “Ugric text” as a special cultural phenomenon. Approximately fifty works by Ugric writers (both, poetic and prosaic) were analyzed using the Internet program, “Morpher”. Despite the obvious differences stylistic and thematic differences in their works, both poets and prose writers use a common set of basic concepts that comprise the backbone of cultural space of the region. The conclusion is made on the similarities that unite the texts of Ugric authors into a single cultural phenomenon. The goal of this research lies in the description of Ugric text as a unique cultural phenomenon. The article employs the results of the latest scientific developments in the field of philological regionalism and geopoetics, as well as literary works by the Ugric authors. The main result consists in elucidation of the concept of “Ugric text”, its differentiation with the concept of “literary school”. Having studied the texts of prominent Ugric writers – E. D. Aypin, S. S. Kozlov, O. B. Richter, P. A. Sukhanov, N. V. Sochikhin, Y. Shestalov and others –  the author concludes on the basic concepts that determine the common mental space of Ugra and ensure the semantic integrity of Ugric text as a cultural phenomenon. It is established that due to the common conceptual framework, Ugric text not only exists as a unified whole, but also evolves, remains contemporary, and meets the spiritual needs of the audience. Comprehensive analysis of the literary works indicates that the common concepts in the poetic and prosaic Ugric text evolve and refract within the framework of the authorial linguistic worldview. The scientific novelty consist sin the fact that this article is first to analyze Ugric texts as a cultural phenomenon from the perspective of conceptual approach.
Play, space, and the magic circle: Reinventing the game
Authors: Honggare Robin Hartanto , Evanindya Fauzia
Published: December 2021

In 2020, Dolanan, a collaborative practice exploring the architectural possibilities of play embedded in Indonesian traditional games, launched its pilot project titled Makan Kerupuk, which experimented on the spatial aspect of the crackers eating game often played during the Independence Day of Indonesia. Driven both by Johan Huizinga’s conceptualisation of the magic circle and the global pandemic, which prevented people from gathering in public space, this project probed into the limit of conventional play-arena by distributing the sites of play into multiple domesticities. Utilising both real and virtual means, Dolanan enacted a version of the game in which participants could engage with the physical experience of playing by employing a dispersal strategy, without dismissing the sense of publicness that marked the national holiday. Images produced by the participants are further analysed in this paper to reflect on the state of the magic circle as conveyed and experienced through this project.
Ruang daring bercerita: Sebuah narasi tentang rute, navigasi, dan batas dalam arsitektur
Authors: Handayani Nina Dwi
Published: December 2021

Kondisi pandemi yang membatasi pola pergerakan manusia atas ruang, di satu sisi menyebabkan manusia kehilangan makna dan rasa atas kehadiran ruang fisik, tapi di sisi lain memberikan peluang bagaimana cara memaknai ruang dengan cara yang berbeda. Instalasi Kisah Antah-berantah karya Citra Sasmita yang diinisiasi oleh Ruang Seni Anak Komisi UOB Museum MACAN, Jakarta ini berkisah tentang cerita fabel mitologis untuk anak-anak yang diinspirasi dari lukisan kamasan dan karakter cerita rakyat Tantri di Bali. Mempergunakan teknologi web-based augmented reality, Kisah Antah-berantah merupakan perpaduan objek seni dan ruang secara fisik dengan teknologi dunia maya, yang bisa dinikmati secara daring dan luring. Pengamatan karya instalasi Kisah Antah-berantah ini bertujuan untuk memperkaya gagasan atas keterlibatan rute, tur dan bagaimana memaknai batas pada ruang maya. 
Pengamatan “mengalami ruang” secara daring oleh penulis dijelaskan melalui 2 cara yaitu mode operasi pasif 360˚ dan mode operasi aktif manual. Mode operasi pasif 360˚ menunjukkan bahwa dengan rute yang statis dan terukur, pengalaman memaknai ruang daring bercerita bisa tercapai, meskipun tidak memberikan pemahaman akan batas ruang yang baru. Sebaliknya dengan mode operasi manual aktif, dengan kebebasan rute yang dipilih dan diciptakan sendiri, pengunjung mampu menciptakan batas dan pemaknaan ruang baru yang berbeda. Dari kedua mode operasi ini, tanda (landmark) berupa titik kode optik hadir melampaui objek fisiknya sebagai bagian dari navigasi dalam ruang maya.
 
 
The pandemic condition that limits human movement over space has consequences that humans lose their meaning and sense of the presence of physical space, otherwise, it provides opportunities to interpret space differently. The installation Kisah Antah-berantah by Citra Sasmita, which was held during a pandemic and initiated by the Ruang Seni Anak Komisi UOB Museum MACAN, Jakarta tells the story of mythological fables for children inspired by kamasan paintings and Tantri folklore characters in Bali, Indonesia. Implementing web-based augmented reality technology, this installation has an equal collaboration of art objects and physical space which can be enjoyed virtually and in a real-time exhibition mode. Kisah Antah-berantah investigates ideas on the involvement of routes, tours, and how to define boundaries in architecture and virtual space.
The "experiencing space" will be explained in 2 ways, namely passive 360˚ operation mode and manual active operation mode. The 360˚ passive mode of operation shows that with a static and measurable route, the visitor interprets the virtual space of storytelling completely, although it does not provide a new understanding of spatial boundaries. In manual active of operation mode, visitors potentially create new boundaries and different meanings of space, by creating their routes. In these two modes of operations, an optical code point is presented as a landmark, as an important part of navigation in virtual space.
Coffee story: Unveiling indigenous delicacy through sensorial transaction
Authors: Hirzan Fariz , Yatmo Yandi Andri
Published: December 2021

This paper explores the potential of spatial atmosphere as the basis of a coffee stall design, creating an intimate understanding of the possible sensory transactions that occurred throughout the coffee-brewing process. In this reflective piece, a coffee stall design process is presented and dissected to unveil the programmatic basis of the design. A closer look at multi-sensory experiences that include sight, smell, and sound in the process of brewing is considered essential. They hold a significant role in perceiving the surrounding atmosphere and how it impacts our design process. A series of equipment and ingredient tracing is conducted to identify the optimal barista's workflow and the production of a multi-sensory experience, rethinking the purpose of the surrounding objects from two different perspectives. Such a process positioned the atmosphere exploration as a focus in achieving a unique programme where the objects within the coffee-making process generate the space through materiality and immateriality.
Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
Authors: Knight John RP , Vlahov Nikola , Gay David M , Ridgway Rachel A , Faller William James , Proud Christopher , Mallucci Giovanna R , von der Haar Tobias , Smales Christopher Mark , Willis Anne E , Sansom Owen J
Published: December 2021

Increased protein synthesis supports the rapid cell proliferation associated with cancer. The Rpl24Bst mutant mouse reduces the expression of the ribosomal protein RPL24 and has been used to suppress translation and limit tumorigenesis in multiple mouse models of cancer. Here, we show that Rpl24Bst also suppresses tumorigenesis and proliferation in a model of colorectal cancer (CRC) with two common patient mutations, Apc and Kras. In contrast to previous reports, Rpl24Bst mutation has no effect on ribosomal subunit abundance but suppresses translation elongation through phosphorylation of eEF2, reducing protein synthesis by 40% in tumour cells. Ablating eEF2 phosphorylation in Rpl24Bst mutant mice by inactivating its kinase, eEF2K, completely restores the rates of elongation and protein synthesis. Furthermore, eEF2K activity is required for the Rpl24Bst mutant to suppress tumorigenesis. This work demonstrates that elevation of eEF2 phosphorylation is an effective means to suppress colorectal tumorigenesis with two driver mutations. This positions translation elongation as a therapeutic target in CRC, as well as in other cancers where the Rpl24Bst mutation has a tumour suppressive effect in mouse models.
Transcriptomic analysis of melon/squash graft junction reveals molecular mechanisms potentially underlying the graft union development
Authors: Xu Chuanqiang , Zhang Ying , Zhao Mingzhe , Liu Yiling , Xu Xin , Li Tianlai
Published: December 2021

Oriental melon (Cucumis melo var. makuwa Makino) has become a widely planted horticultural crop in China especially in recent years and has been subjected to the grafting technique for the improvement of cultivation and stress resistance. Although grafting has a long history in horticulture, there is little known about the molecular mechanisms of the graft healing process in oriental melon. This study aims to reveal the molecular changes involved in the graft healing process. In the present work, anatomical observations indicated that the 2, 6, and 9 DAG were three critical stages for the graft healing and therefore, were selected for the subsequent high-throughput RNA-seq analysis. A total of 1,950 and 1,313 DEGs were identified by comparing IL vs. CA and CA vs. VB libraries, respectively. More DEGs in the melon scion exhibited abundant transcriptional changes compared to the squash rootstock, providing increased metabolic activity and thus more material basis for the graft healing formation in the scion. Several DEGs were enriched in the plant hormone signal transduction pathway, phenylpropanoid biosynthesis, and carbon metabolism. In addition, the results showed that concentrations of IAA, GA3, and ZR were induced in the graft junctions. In conclusion, our study determined that genes involved in the hormone-signaling pathway and lignin biosynthesis played the essential roles during graft healing. These findings expand our current understandings of the molecular basis of the graft junction formation and facilitate the improvement and success of melon grafting in future production.
A Systematic Review of Studies Comparing Actigraphy Indices in Patients with Depression and Schizophrenia
Authors: Ransing Ramdas , Patil Pradeep , Khapri Anurag , Mahindru Aditya
Published: December 2021

Introduction: Abnormalities in sleep-wake activities are frequently observed among patients with depression and schizophrenia. These abnormalities are variable and may have discriminative, clinical, diagnostic, and therapeutic significance if measured objectively with actigraphy. Aim: To systematically review the published literature on actigraphy in depression and schizophrenia, particularly to identify areas of research that need to be addressed before their clinical application in practice. Materials and Methods: The electronic databases (PubMed and Google Scholar) were searched for studies using the the key terms ‘actigraphy’ OR ‘actigraphic recording’ OR ‘wrist actigraphy’ OR ‘actometer’ OR ‘actimeter’ OR ‘actical’ OR ‘actiwatch’ OR ‘sleep- watch’ AND ‘schizoaffective’ OR ‘schizophr*’ OR ‘psychosis’ AND ‘depression’ OR ‘depressive’ in title and abstract. The literature search was limited to articles published in English and until 31st December, 2020. Data were abstracted by two reviewers and presented as a narrative summary of the findings. A qualitative synthesis of the study designs, populations, and outcomes was conducted. The quantitative synthesis of the results was not possible to conduct due to the heterogeneity and scarcity of the included studies. Results: Out of 33 searched articles, a total of four studies (three observational and one case report) were included for the review. The included studies were heterogeneous, small in sample size, divergent in methods, inclusive of clinical population, having more than two groups (depression, schizophrenia, mania, or bipolar disorders), and with a low degree of evidence. Overall, the patients with schizophrenia have more structured and less complex activity pattern than those with depression. Furthermore, the patients with schizophrenia showed more irregular patterns in the morning period and increased fluctuations inactivity in the evening period than depression patients. Conclusion: Currently, available information is insufficient to draw firm conclusions on use of actigraphy indices (e.g., duration of active periods, a pattern of activity, and sleep) for diagnosis and discrimination among the patients with schizophrenia and depression. Large, prospective, and comparative studies are required to identify role of actigraphy among these patients.
Drug Utilisation Pattern and Adverse Drug Reactions in Stage II Breast Cancer Patients in a Tertiary Care Centre of Odisha- An Observational Study
Authors: Rout Anima , Das Priti , Tripathy Ratikanta , Agarwalla Dillip Kumar , Mishra Vedvyas
Published: December 2021

Introduction: Breast cancer is the most common cancer occurring in women with an estimated prevalence of 28.94% in Cuttack, Odisha, India. Adverse Drug Reactions (ADRs) associated with the use of anticancer drugs is a worldwide problem which needs further attention. Aim: To know about treatment regimens, premedications used for toxicity amelioration or any associated ADRs occurring during treatment of stage II breast cancer patients. Materials and Methods: This was a prospective observational study carried out in the Department of Pharmacology in collabo- ration with Acharya Harihar Regional Cancer Center (AHRCC), SCB Medical College and Hospital, Odisha, India. A total of 181 female breast cancer patients of stage II were finally analysed about their treatment protocol pattern including premedication, chemotherapy regimen, associated ADRs and their treatment. Different outcomes measured were Absolute Neutrophil Count (ANC), febrile neutropenia, anaemia, thrombocytopenia. ADRs were analysed by using World Health Organisation-Uppsala Monitoring Centre (WHO-UMC) Scale and Hartwig-Siegel Scale. All analysis was performed using Statistical Package For the Social Sciences (SPSS) version 18.0. Results: Most common chemotherapy combination regimen used was cyclophosphamide+doxorubicin+paclitaxel+trastuzumab in 30.9% of patients, out of which 28.7% showed ADRs. Ondansetron and aprepitant were commonly used as premedication in 96% of patients. Most commonly reported ADR was Chemotherapy Induced Nausea and Vomiting (CINV) in 43.6% patients and Chemotherapy Induced Neutropenia (CIN) (34.8%). Fifty percent ADRs were mild and 3.3% ADRs were severe in nature. A 64% ADRs were possible and 23% ADRs were probable according to WHO-UMC causality assessment scale. Grade 4 Neutropenia was present in 1.3% patients. Mild haematological problems were treated by blood transfusion while severe cases by additional growth factor support like Granulocyte Colony Stimulating Factor (G-CSF). In this study, mean age of presentation was found to be 44.6 years. Conclusion: Despite use of drugs for toxicity amelioration, some grade four life threatening ADRs were observed. Mostly ADRs were missed and under-reported. Regular monitoring, increased care and patient compliance was needed to detect new ADRs and to reduce the morbidity as well as burden on the patients.
Constraints Faced by Vegetable Growers in Amaravati Division of Maharashtra
Authors: Sindhura K. , Tekale V. S. , Thakre Pranali N.
Published: December 2021

Vegetable cultivation involves intensive cultural operations since sowing to marketing, providing regular employment opportunities to unemployed youth and farm family. Vegetable production is now commercialized, but still traditional farming is done in far flung areas. Besides, they are not as well served by the extension system as the farmers growing food grains. Moreover, most of the vegetable growers in this region are small and marginal farmers, and they have their peculiar concerns and problems which need to be studied urgently and earnest. The present study was carried out in Akola and Amravati districts of Vidarbha region of Maharashtra state during the year 2019 with a sample size of 120 respondents to define the constraints faced by vegetable growers in Amravati division of Maharashtra. The major constraints faced by the vegetable growers were price fluctuation, electricity, fertigation, exploitation by middle men and lack of market knowledge.
Hyperuricemia and Smoking Correlation in Egyptian Young Adults with Coronary Artery Disease: Observational Study
Authors: El-Sayed Youssef Ali Youssef , Badr Seham Fahmy , Abd El-Aal Mohamed Ahmed , El-Sheikh Ayman Ahmed
Published: December 2021

Background: Young adults, especially those under 35, are often overlooked; however, previous studies have shown that coronary artery disease (CAD) incidence increases rapidly. Previous studies proved many risk factors for CAD, such as hyperlipidemia, hypertension, diabetes, and smoking. The present study ultimately aimed to figure out the correlation between Hyperuricemia (HUA) and smoking in CAD Patients under the age of 35.

Methods: This observational study included 100 young adults (18–35 years of age) suspected of CAD. We used the Gensini Score system to ascertain coronary angiography outcome and CAD; based on the number of affected vessels, localization of the segment, and the stenosis grade.

The Gensini score being > 0 indicated the presence of CAD.

Results: In young adults under 35, there was a significant correlation between HUA and CAD. The interaction between HUA and smoking had a contrast for CAD that statistically shown the existence of CAD increased in patients who have hyperuricemia and non-smokers compared to smokers.

Conclusions: By monitoring various parameters in young adults ≤ 35 years old. This study strengthens the correlation between:1) hyperuricemia and the occurrence of CAD, 2) Smoking and the CAD. Furthermore, there is a clear association between HUA and the occurrence of CAD in non-smokers.
Effect of Different Nutrient Management Practices on Productivity and Profitability of Double Zero Indian Mustard (Brassica juncea L.)
Authors: Indira Gajjela , Yadav R. B. , Vivek . , Naresh R. K. , Chandra M. Sharath , Chandrakanth Alladi , Shivangi . , Nath Ashish
Published: December 2021

A field experiment was conducted at Crop Research Center, Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut, Uttar Pradesh in Rabi season 2021 with a view to compare the production potential under different nutrient management practices and also to find out the economic viability of this cultivar for soil quality. The experiment was analysed in Randomised block design (RBD) and the treatments comprised of Control (T1), 100% N (T2), 100% NP (T3), 100% NPK (T4), 125%NPK (T5), 100% NPK+ S@40kg ha-1 (T6), 100%NPK+ Zn@5kg ha-1 (T7), 100%NPK + B@1kg ha-1 (T8), 75% NPK+ VC@ 2t  ha-1 (T9), 75%NPK+FYM@ 6t   ha-1  (T10), 75%NPK + VC@ 2t ha-1+ Azotobacter (T11) and  75%.

NPK + FYM@6t ha-1 + Azotobacter (T12). Results revealed that treatment T11 and T12  exhibited significant influence on yield attributes and yields of mustard as compared to the application of 100% NPK alone. The maximum gross return was obtained in T12 followed by T11. The highest net return was obtained in T5 followed by T12, T6 and T11, whereas, minimum gross return and net return was obtained in T1.T11 recorded higher gross return and net return but the B:C ratio was lower due to higher cost of vermicompost. Higher values of B: C ratio (4.23) was obtained in T6 and T5 respectively. The current study reveals that T11 and T12 exhibited significant beneficial for yield, yield attributes and profitability of mustard.
Nocturnal Enuresis in Primary Schools Children (6-12 Years) of Tabuk City, Saudi Arabia
Authors: Alomani Omaima Tawfiq , Khalil Tahani
Published: December 2021

Background: Regardless of the significance and the disturbing magnitudes of NE, this problem remains under-reported in Tabuk, Saudi Arabia and comprehensive studies in this regard are considerably lacking in that region. This study aimed to discuss the prevalence and associated risk factors of NE among children in Saudi Arabia.

Methodology: A cross sectional study design was adopted in Tabuk, KSA using a self-administered questionnaire for data collection distributed online on social media sites to be filled out personally. All data were collected, tabulated, and statistically analyzed using SPSS 23.0 for windows (SPSS Inc., Chicago, IL, USA).

Results: The study included 431 participants. (37.4%) of children aged between six and seven years old, (32.7%) between eight and nine years old, and (17.2%) between ten and twelve years old. (58.9%) of children were males and (41.1%) females. Average frequency various from (53.8%) one time to two times per week, (31.3%) three times to four times per week, (14.8% five times to seven times per week. Enuresis was at night only in (77.5%) while (22.5%) at day or night. (64.5%) don’t seek to medical advice, while (35.5%) getting medical advice. (48.5%) of children getting behavioral therapy to treat this condition, (15.8%) exercise to strengthen bladder muscles, (14.6%) getting medical treatment, (10%) getting urination alarm, (0.5%) doing surgical intervention. There was a significant relationship between frequency per week of enuresis with mother educational level, number of family member, age of child (6-7) years old, sex of child (female), family history of nocturnal enuresis and delayed growth. Also, there was a significant relation between timing of enuresis during night or day and night with parents suffering from nocturnal enuresis, father’s education level, mother’s education level, and caring of parents to awaken the child.

Conclusion: Nocturnal enuresis associated factors and parenteral knowledge of definition and causes of it were among universal reported figures. Referral to a pediatric urologist can be indicated for children with primary enuresis refractory to standard and combination therapies, and for children with some secondary causes of enuresis, including urinary tract malformations, recurrent urinary tract infections, or neurologic disorders.
Formulation Development and Evaluation of Migraine Almotriptan Loaded Ethosomes Using Box Behnken Design
Authors: Parashar Megha , Jain Ashish
Published: December 2021

One of the most common nervous system illnesses is headache disorders, which are characterized by chronic headaches. In Present investigation Almotriptan loaded Ethosomes were prepared by water phase addition method. The three independent factors including Phosphotidylcholine: Cholestrol: DSPE (6:3:1molar ratio), Surfactant concentration and sonication time. A factorial design 3*3(3 factor 3 level) was applied to prepare 17 formulation. Optimization of ethosomal preparation was carried out by applying Box Behnken response surface randomized factorial design following quadratic model using Design of Experiment (DOE) software version 11.04.0.  The factor Soya PC: Cholesterol: DSPE in molar ration (6:3:1), Concentration of Tween-80 and sonication time were selected as dependable process and formulation factors that can be effect formulation characteristics like entrapment efficiency, average vesicle size, Polydispersity Index (PDI). All other factors like sonication speed and rotation speed was kept constant All the formulation were prepared by simple solvent evaporation thin film formation method and characterized for the drug entrapment, average vesicle size and PDI, shape morphology. Formulations were optimized on the basis of responses such as average vesicle size, PDI, and entrapment efficiency. All the characterized values of the responses were putted in the formulation design table and analyse to best fitted model for the design. It was observed that, quadaratic model is best fitted model for the design. The prepared ethosomes formulation can further incorporated in situ gel for effective treatment of migraine.
Report of a recent examination of the Roman Camp at Cleghorn, Lanarkshire, styled 'Agricola's Camp;' with Notices of General Roy and his Family
Authors: Rankin D R
Published: December 2021

The author has issued a correction to the publication Caledonia Romana by Robert Stuart (1845). Stuart's publication claims that Agricola's camp near Cleghorn is on the right of the road to Edinburgh and that only one part of its ramparts remains visible. However, according to Rankin, this camp is on the left of the road and is mostly in tact. He relates a description of the current state of the camps at Cleghorn and Castledykes with regerence to General Roy's plans from 1753 an 1764. Rankin then finishes with a brief overview of General Roy's early life in Carluke.

 

Meetings minutes for 14 March 1853 are appended.
On some suggestive examples of Abortive Discovery in Ancient Art
Authors: - - , Wilson Daniel
Published: December 2021

The final conversazione of this session was held in the Society's rooms on 26 April 1853.

 

Dr Daniel Wilson delivered a lecture on brass engravings. He argues that the Society's collection of ancient art can be viewed as examples of early engraved printing plates (chalcographic art). He discusses examples from throughout antiquity and the medieval period, referencing brass engravings from Europe, Africa and Asia. He notes that although ancient engraved pieces could be used to create printed artwork, they were not used for this purpose because of how delicate and valuable they were. He also touches on other forms of engraving including wood engraving, seal and gem engraving, engraved personal ornaments, and the use of engraving in creating materials for printing presses or coin mints. He concludes with examples of engraved items found in Scotland on both Roman and church sites.

 

The meeting notes for 9 May 1853 are appended.
An attempt to define how far the cymric encroached upon the Gaelic Branch of the early Celtic population of North Britain
Authors: Rhind Alexander Henry
Published: December 2021

The author presents his argument regarding the extent of Brittonic territory in Roman-age Scotland. He compares the names of tribes recorded in Ptolemy's Geography to similar tribal names recorded in southern parts of Britain and concludes that there is significant overlap for tribal names in the central belt, as well as the areas that are now Fife, Perthshire and Angus. He also supports his argument with evidence from contemporary place-names, particularly the use of the prefix 'aber', that he argues is imported from Brittonic areas such as Wales rather than Gaelic-speaking Ireland. Rhind summarises his argument through using tables and lists at the end of the article.

 

Meeting notes for the meeting held 13 June 1853 are appended.