bluuebunny/crossref_metadata_2025 huggingface dataset:
Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant
Authors: Zuo Fanglei , Abolhassani Hassan , Du Likun , Piralla Antonio , Bertoglio Federico , de Campos-Mata Leire , Wan Hui , Schubert Maren , Cassaniti Irene , Wang Yating , Sammartino Josè Camilla , Sun Rui , Vlachiotis Stelios , Bergami Federica , Kumagai-Braesch Makiko , Andréll Juni , Zhang Zhaoxia , Xue Yintong , Wenzel Esther Veronika , Calzolai Luigi , Varani Luca , Rezaei Nima , Chavoshzadeh Zahra , Baldanti Fausto , Hust Michael , Hammarström Lennart , Marcotte Harold , Pan-Hammarström Qiang
Published: May 2022

The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and the urgent need to study more efficient vaccination strategies. Here we observed that an mRNA vaccine booster in individuals vaccinated with two doses of inactivated vaccine significantly increased the plasma level of specific antibodies that bind to the receptor-binding domain (RBD) or the spike (S) ectodomain (S1 + S2) of both the G614 and the Omicron variants, compared to two doses of homologous inactivated vaccine. The level of RBD- and S-specific IgG antibodies and virus neutralization titers against variants of concern in the heterologous vaccination group were similar to that in individuals receiving three doses of homologous mRNA-vaccine or a boost of mRNA vaccine after infection, but markedly higher than that in individuals receiving three doses of a homologous inactivated vaccine. This heterologous vaccination regime furthermore significantly enhanced the RBD-specific memory B cell response and S1-specific T cell response, compared to two or three doses of homologous inactivated vaccine. Our study demonstrates that mRNA vaccine booster in individuals vaccinated with inactivated vaccines can be highly beneficial, as it markedly increases the humoral and cellular immune responses against the virus, including the Omicron variant.
Anomalous non-equilibrium response in black phosphorus to sub-gap mid-infrared excitation
Authors: Montanaro Angela , Giusti Francesca , Zanfrognini Matteo , Di Pietro Paola , Glerean Filippo , Jarc Giacomo , Rigoni Enrico Maria , Mathengattil Shahla Y. , Varsano Daniele , Rontani Massimo , Perucchi Andrea , Molinari Elisa , Fausti Daniele
Published: May 2022

The competition between the electron-hole Coulomb attraction and the 3D dielectric screening dictates the optical properties of layered semiconductors. In low-dimensional materials, the equilibrium dielectric environment can be significantly altered by the ultrafast excitation of photo-carriers, leading to renormalized band gap and exciton binding energies. Recently, black phosphorus emerged as a 2D material with strongly layer-dependent electronic properties. Here, we resolve the response of bulk black phosphorus to mid-infrared pulses tuned across the band gap. We find that, while above-gap excitation leads to a broadband light-induced transparency, sub-gap pulses drive an anomalous response, peaked at the single-layer exciton resonance. With the support of DFT calculations, we tentatively ascribe this experimental evidence to a non-adiabatic modification of the screening environment. Our work heralds the non-adiabatic optical manipulation of the electronic properties of 2D materials, which is of great relevance for the engineering of versatile van der Waals materials.
Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3
Authors: Shih Pu-Yun , Fang Yu-Lun , Shankar Sahana , Lee Sue-Ping , Hu Hsiao-Tang , Chen Hsin , Wang Ting-Fang , Hsia Kuo-Chiang , Hsueh Yi-Ping
Published: May 2022

Many synaptic proteins form biological condensates via liquid-liquid phase separation (LLPS). Synaptopathy, a key feature of autism spectrum disorders (ASD), is likely relevant to the impaired phase separation and/or transition of ASD-linked synaptic proteins. Here, we report that LLPS and zinc-induced liquid-to-gel phase transition regulate the synaptic distribution and protein-protein interaction of cortactin-binding protein 2 (CTTNBP2), an ASD-linked protein. CTTNBP2 forms self-assembled condensates through its C-terminal intrinsically disordered region and facilitates SHANK3 co-condensation at dendritic spines. Zinc binds the N-terminal coiled-coil region of CTTNBP2, promoting higher-order assemblies. Consequently, it leads to reduce CTTNBP2 mobility and enhance the stability and synaptic retention of CTTNBP2 condensates. Moreover, ASD-linked mutations alter condensate formation and synaptic retention of CTTNBP2 and impair mouse social behaviors, which are all ameliorated by zinc supplementation. Our study suggests the relevance of condensate formation and zinc-induced phase transition to the synaptic distribution and function of ASD-linked proteins.
Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ
Authors: Liu Yi , Deguchi Yasunori , Wei Daoyan , Liu Fuyao , Moussalli Micheline J. , Deguchi Eriko , Li Donghui , Wang Huamin , Valentin Lovie Ann , Colby Jennifer K. , Wang Jing , Zheng Xiaofeng , Ying Haoqiang , Gagea Mihai , Ji Baoan , Shi Jiaqi , Yao James C. , Zuo Xiangsheng , Shureiqi Imad
Published: May 2022

Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to PDAC. Critical factors that promote this progression, especially targetable ones, remain poorly defined. We show that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, is upregulated in PanINs in humans and mice. Furthermore, PPARδ ligand activation by a high-fat diet or GW501516 (a highly selective, synthetic PPARδ ligand) in mutant KRASG12D (KRASmu) pancreatic epithelial cells strongly accelerates PanIN progression to PDAC. This PPARδ activation induces KRASmu pancreatic epithelial cells to secrete CCL2, which recruits immunosuppressive macrophages and myeloid-derived suppressor cells into pancreas via the CCL2/CCR2 axis to orchestrate an immunosuppressive tumor microenvironment and subsequently drive PanIN progression to PDAC. Our data identify PPARδ signaling as a potential molecular target to prevent PDAC development in subjects harboring PanINs.
Modulating gene regulation function by chemically controlled transcription factor clustering
Authors: Wu Jiegen , Chen Baoqiang , Liu Yadi , Ma Liang , Huang Wen , Lin Yihan
Published: May 2022

Recent studies have suggested that transcriptional protein condensates (or clusters) may play key roles in gene regulation and cell fate determination. However, it remains largely unclear how the gene regulation function is quantitatively tuned by transcription factor (TF) clustering and whether TF clustering may confer emergent behaviors as in cell fate control systems. Here, to address this, we construct synthetic TFs whose clustering behavior can be chemically controlled. Through single-parameter tuning of the system (i.e., TF clustering propensity), we provide lines of evidence supporting the direct transcriptional activation and amplification of target genes by TF clustering. Single-gene imaging suggests that such amplification results from the modulation of transcriptional dynamics. Importantly, TF clustering propensity modulates the gene regulation function by significantly tuning the effective TF binding affinity and to a lesser extent the ultrasensitivity, contributing to bimodality and sustained response behavior that are reminiscent of canonical cell fate control systems. Collectively, these results demonstrate that TF clustering can modulate the gene regulation function to enable emergent behaviors, and highlight the potential applications of chemically controlled protein clustering.
Polygonal non-wetting droplets on microtextured surfaces
Authors: Lou Jing , Shi Songlin , Ma Chen , Zhou Xiaohuan , Huang Dong , Zheng Quanshui , Lv Cunjing
Published: May 2022

Understanding the interactions between liquids and solids is important for many areas of science and technology. Microtextured surfaces have been extensively studied in microfluidics, DNA technologies, and micro-manufacturing. For these applications, the ability to precisely control the shape, size and location of the liquid via textured surfaces is of particular importance for the design of fluidic-based systems. However, this has been passively realized in the wetting state thanks to the pinning of the contact line, leaving the non-wetting counterpart challenging due to the low liquid affinity. In this work, confinement is imposed on droplets located on well-designed shapes and arrangements of microtextured surfaces. An active way to shape non-wetting water and liquid metal droplets into various polygons ranging from triangles, squares, rectangles, to hexagons is developed. The results suggest that energy barriers in different directions account for the movement of the contact lines and the formation of polygonal shapes. By characterizing the curvature of the liquid-vapour meniscus, the morphology of the droplet is correlated to its volume, thickness, and contact angle. The developed liquid-based patterning strategy under active regulation with low adhesion looks promising for low-cost micromanufacturing technology, DNA microarrays, and digital lab-on-a-chip.
Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms
Authors: Ajayi Peter T. , Katti Prasanna , Zhang Yingfan , Willingham T. Bradley , Sun Ye , Bleck Christopher K. E. , Glancy Brian
Published: May 2022

Skeletal muscles play a central role in human movement through forces transmitted by contraction of the sarcomere. We recently showed that mammalian sarcomeres are connected through frequent branches forming a singular, mesh-like myofibrillar matrix. However, the extent to which myofibrillar connectivity is evolutionarily conserved as well as mechanisms which regulate the specific architecture of sarcomere branching remain unclear. Here, we demonstrate the presence of a myofibrillar matrix in the tubular, but not indirect flight (IF) muscles within Drosophila melanogaster. Moreover, we find that loss of transcription factor H15 increases sarcomere branching frequency in the tubular jump muscles, and we show that sarcomere branching can be turned on in IF muscles by salm-mediated conversion to tubular muscles. Finally, we demonstrate that neurochondrin misexpression results in myofibrillar connectivity in IF muscles without conversion to tubular muscles. These data indicate an evolutionarily conserved myofibrillar matrix regulated by both cell-type dependent and independent mechanisms.
Chest-scale self-compensated epidermal electronics for standard 6-precordial-lead ECG
Authors: Yin Lang , Wang Youhua , Zhan Jian , Bai Yunzhao , Hou Chao , Wu Junfeng , Huang Rong , Wang Yuzhou , Huang YongAn
Published: May 2022

Six chest leads are the standardized clinical devices of diagnosing cardiac diseases. Emerging epidermal electronics technology shift the dangling wires and bulky devices to imperceptible wearing, achieving both comfortable experience and high-fidelity measuring. Extending small areas of current epidermal electronics to the chest scale requires eliminating interference from long epidermal interconnects and rendering the data acquisition (DAQ) portable. Herein, we developed a chest-scale epidermal electronic system (EES) for standard precordial-lead ECG and hydration monitoring, including the only μm-thick substrate-free epidermal sensing module and the soft wireless DAQ module. An electrical compensation strategy using double channels within the DAQ module and epidermal compensated branches (ECB) is proposed to eliminate unwanted signals from the long epidermal interconnects and to achieve the desired ECG. In this way, the EES works stably and precisely under different levels of exercise. Patients with sinus arrhythmias have been tested, demonstrating the prospect of EES in cardiac diseases.
Scalable estimation of pure multi-qubit states
Authors: Pereira Luciano , Zambrano Leonardo , Delgado Aldo
Published: May 2022

We introduce an inductiven-qubit pure-state estimation method based on projective measurements onmn + 1 separable bases ormentangled bases plus the computational basis, withm ≥ 2. The method exhibits a favorable scaling in the number of qubits compared to other estimation schemes. The use of separable bases makes our estimation method particularly well suited for applications in noisy intermediate-scale quantum computers, where entangling gates are much less accurate than local gates. Our method is also capable of estimating the purity of mixed states generated by the action of white noise on pure states. Monte Carlo simulations show that the method achieves a high estimation fidelity. Besides, the fidelity can be improved by increasingmabove 2. We experimentally demonstrate the method on the IBM’s quantum processors by estimating up to 10-qubit separable and entangled states. In particular, a 4-qubit GHZ is estimated with experimental fidelity of 0.875.
Mussel-inspired multifunctional surface through promoting osteogenesis and inhibiting osteoclastogenesis to facilitate bone regeneration
Authors: Wu Minhao , Zhang Yufeng , Wu Ping , Chen Feixiang , Yang Zhiqiang , Zhang Sheng , Xiao Lingfei , Cai Lin , Zhang Chong , Chen Yun , Deng Zhouming
Published: May 2022

Osteogenesis and osteoclastogenesis are closely associated during the bone regeneration process. The development of multifunctional bone repair scaffolds with dual therapeutic actions (pro-osteogenesis and anti-osteoclastogenesis) is still a challenging task for bone tissue engineering applications. Herein, through a facile surface coating process, mussel-inspired polydopamine (PDA) is adhered to the surface of a biocompatible porous scaffold followed by the immobilization of a small-molecule activator (LYN-1604 (LYN)) and the subsequent in situ coprecipitation of hydroxyapatite (HA) nanocrystals. PDA, acting as an intermediate bridge, can provide strong LYN immobilization and biomineralization ability, while LYN targets osteoclast precursor cells to inhibit osteoclastic differentiation and functional activity, which endows LYN/HA-coated hybrid scaffolds with robust anti-osteoclastogenesis ability. Due to the synergistic effects of the LYN and HA components, the obtained three-dimensional hybrid scaffolds exhibited the dual effects of osteoclastic inhibition and osteogenic stimulation, thereby promoting bone tissue repair. Systematic characterization experiments confirmed the successful fabrication of LYN/HA-coated hybrid scaffolds, which exhibited an interconnected porous structure with nanoroughened surface topography, favorable hydrophilicity, and improved mechanical properties, as well as the sustained sequential release of LYN and Ca ions. In vitro experiments demonstrated that LYN/HA-coated hybrid scaffolds possessed satisfactory cytocompatibility, effectively promoting cell adhesion, spreading, proliferation, alkaline phosphatase activity, matrix mineralization, and osteogenesis-related gene and protein secretion, as well as stimulating angiogenic differentiation of endothelial cells. In addition to osteogenesis, the engineered scaffolds also significantly reduced osteoclastogenesis, such as tartrate-resistant acid phosphatase activity, F-actin ring staining, and osteoclastogenesis-related gene and protein secretion. More importantly, in a rat calvarial defect model, the newly developed hybrid scaffolds significantly promoted bone repair and regeneration. Microcomputed tomography, histological, and immunohistochemical analyses all revealed that the LYN/HA-coated hybrid scaffolds possessed not only reliable biosafety but also excellent osteogenesis-inducing and osteoclastogenesis-inhibiting effects, resulting in faster and higher-quality bone tissue regeneration. Taken together, this study offers a powerful and promising strategy to construct multifunctional nanocomposite scaffolds by promoting osteo/angiogenesis and suppressing osteoclastogenesis to accelerate bone regeneration.
Spatial distribution data of cultural sites from the Paleolithic to Bronze Age in Xinjiang, China
Authors: Tan Bo , Wang Hongwei , Wang Xiaoqin , Yi Suyan , Zhou Jing , Ma Chen , Dai Xinyan
Published: May 2022

The published map recording cultural sites in Xinjiang shows that there is a lack of data collection on the distribution of sites in the area, and no relevant data sets have been released. Existing written materials indicate that there are more cultural sites in this area. For this reason, we have collected and sorted out information. Our cultural site database provides the geographic location and corresponding geographic environment of each site in Xinjiang from the Paleolithic to the Bronze Age. The data record the human development and settlement process, settlement environment landscape characteristics, scale, type, quantity, and spatial distribution in Xinjiang in prehistoric China. These data not only are the basis for further understanding the spatial distribution of prehistoric humans in Xinjiang, but also provide references for understanding prehistoric human behavior and prehistoric man-land relationship, and the exchange of eastern and western civilizations. It is of great significance to modern social planning, site protection, and resource utilization.
Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats
Authors: Justen Hannah , Hasselmann Timo , Illera Juan Carlos , Delmore Kira E. , Serrano David , Flinks Heiner , Senzaki Masayuki , Kawamura Kazuhiro , Helm Barbara , Liedvogel Miriam
Published: May 2022

Timing is essential for survival and reproduction of organisms across the tree of life. The core circadian clock geneClkis involved in the regulation of annual timing events and shows highly conserved sequence homology across vertebrates except for one variable region of poly-glutamine repeats.Clkgenotype varies in some species with latitude, seasonal timing and migration. However, findings are inconsistent, difficult to disentangle from environmental responses, and biased towards high latitudes. Here we combine field data with a common-garden experiment to study associations ofClkpolymorphism with latitude, migration and annual-cycle timing within the stonechat species complex across its trans-equatorial distribution range. Our dataset includes 950 records from 717 individuals from nine populations with diverse migratory strategies. Gene diversity was lowest in resident African and Canary Island populations and increased with latitude, independently of migration distance. Repeat length and annual-cycle timing was linked in a population-specific way. Specifically, equatorial African stonechats showed delayed timing with longer repeat length for all annual-cycle stages. Our data suggest that at low latitudes with nearly constant photoperiod,Clkgenotype might orchestrate a range of consistent, individual chronotypes. In contrast, the influence ofClkon annual-cycle timing at higher latitudes might be mediated by its interactions with genes involved in (circadian) photoperiodic pathways.
Differential expression analysis of genes and long non-coding RNAs associated with KRAS mutation in colorectal cancer cells
Authors: Saliani Mahsa , Jalal Razieh , Javadmanesh Ali
Published: May 2022

KRAS mutation is responsible for 40–50% of colorectal cancers (CRCs). RNA-seq data and bioinformatics methods were used to analyze the transcriptional profiles of KRAS mutant (mtKRAS) in comparison with the wild-type (wtKRAS) cell lines, followed by in-silico and quantitative real-time PCR (qPCR) validations. Gene set enrichment analysis showed overrepresentation of KRAS signaling as an oncogenic signature in mtKRAS. Gene ontology and pathway analyses on 600 differentially-expressed genes (DEGs) indicated their major involvement in the cancer-associated signal transduction pathways. Significant hub genes were identified through analyzing PPI network, with the highest node degree for PTPRC. The evaluation of the interaction between co-expressed DEGs and lncRNAs revealed 12 differentially-expressed lncRNAs which potentially regulate the genes majorly enriched in Rap1 and RAS signaling pathways. The results of the qPCR showed the overexpression of PPARG and PTGS2, and downregulation of PTPRC in mtKRAS cells compared to the wtKRAS one, which confirming the outputs of RNA-seq analysis. Further, significant upregualtion of miR-23b was observed in wtKRAS cells. The comparison between the expression level of hub genes and TFs with expression data of CRC tissue samples deposited in TCGA databank confirmed them as distinct biomarkers for the discrimination of normal and tumor patient samples. Survival analysis revealed the significant prognostic value for some of the hub genes, TFs, and lncRNAs. The results of the present study can extend the vision on the molecular mechanisms involved in KRAS-driven CRC pathogenesis.
Design of double sampling inspection plans for life tests under time censoring based on Pareto type IV distribution
Authors: Saranya C. R. , Vijayaraghavan R. , Sathya Narayana Sharma K.
Published: May 2022

Sampling inspection plans for life tests, called reliability sampling plans, are generally employed to determine the acceptance or non-acceptance of the lot(s) of finished products by performing tests on the sampled items, measuring the lifetime of the items and observing the number of failures of items. Lifetime of individual items is a prime quality characteristic that can be treated as a continuous random variable and can be modeled by an appropriate probability distribution. In this article, double sampling plans for life tests under time censoring with a provision to draw two random samples and to admit a maximum of one failure in the combined samples are formulated assuming that the lifetime random variable follows a Pareto type IV distribution. A methodical procedure for the selection of the plan parameters using reliable life criterion with the desired discrimination protecting the interests of the producer and the consumer in terms of the acceptable reliable life and unacceptable reliable life is evolved. The operating ratio is used as a measure of discrimination in designing the proposed reliability sampling plans.
Pd-containing magnetic periodic mesoporous organosilica nanocomposite as an efficient and highly recoverable catalyst
Authors: Neysi Maryam , Elhamifar Dawood
Published: May 2022

A novel magnetic ionic liquid based periodic mesoporous organosilica supported palladium (Fe3O4@SiO2@IL-PMO/Pd) nanocomposite is synthesized, characterized and its catalytic performance is investigated in the Heck reaction. The Fe3O4@SiO2@IL-PMO/Pd nanocatalyst was characterized using FT-IR, PXRD, SEM, TEM, VSM, TG, nitrogen-sorption and EDX analyses. This nanocomposite was effectively employed as catalyst in the Heck reaction to give corresponding arylalkenes in high yield. The recovery test was performed to study the catalyst stability and durability under applied conditions.
Improving the design stage of air pollution studies based on wind patterns
Authors: Zabrocki Léo , Alari Anna , Benmarhnia Tarik
Published: May 2022

A growing literature in economics and epidemiology has exploited changes in wind patterns as a source of exogenous variation to better measure the acute health effects of air pollution. Since the distribution of wind components is not randomly distributed over time and related to other weather parameters, multivariate regression models are used to adjust for these confounding factors. However, this type of analysis relies on its ability to correctly adjust for all confounding factors and extrapolate to units without empirical counterfactuals. As an alternative to current practices and to gauge the extent of these issues, we propose to implement a causal inference pipeline to embed this type of observational study within an hypothetical randomized experiment. We illustrate this approach using daily data from Paris, France, over the 2008–2018 period. Using the Neyman–Rubin potential outcomes framework, we first define the treatment of interest as the effect of North-East winds on particulate matter concentrations compared to the effects of other wind directions. We then implement a matching algorithm to approximate a pairwise randomized experiment. It adjusts nonparametrically for observed confounders while avoiding model extrapolation by discarding treated days without similar control days. We find that the effective sample size for which treated and control units are comparable is surprisingly small. It is however reassuring that results on the matched sample are consistent with a standard regression analysis of the initial data. We finally carry out a quantitative bias analysis to check whether our results could be altered by an unmeasured confounder: estimated effects seem robust to a relatively large hidden bias. Our causal inference pipeline is a principled approach to improve the design of air pollution studies based on wind patterns.
Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures
Authors: Takatsuki Hanae , Imamura Morikazu , Mori Tsuyoshi , Atarashi Ryuichiro
Published: May 2022

Each prion strain has its own characteristics and the efficacy of anti-prion drugs varies. Screening of prion disease therapeutics is typically evaluated by measuring amounts of protease-resistant prion protein (PrP-res). However, it remains unclear whether such measurements correlate with seeding activity, which is evaluated by real-time quaking-induced conversion (RT-QuIC). In this study, the effects of anti-prion compounds pentosan polysulfate (PPS), Congo red, and alprenolol were measured in N2a58 cells infected with Fukuoka-1 (FK1) or 22L strain. The compounds abolished PrP-res and seeding activity, except for N2a58/FK1 treated with PPS. Interestingly, the seeding activity of N2a58/FK1, which was reduced in the presence of PPS, was not lost and remained at low levels. However, upon removal of PPS, both were gradually restored to their original levels. These results indicate that low-level persistent prion infection keeping measurable seeding activity is induced by PPS in a strain-dependent manner. Furthermore, for protein misfolding cyclic amplification (PMCA), the anti-prion effect of PPS decreased in FK1 compared to 22L, suggesting that the differences occur at the level of the direct conversion. Our findings demonstrate that the advantages of RT-QuIC and PMCA can be exploited for more accurate assessment of therapeutic drug screening, reflecting strain differences.
Biomarker identification by reversing the learning mechanism of an autoencoder and recursive feature elimination
Authors: Al Abir Fuad , Shovan S. M. , Hasan Md. Al Mehedi , Sayeed Abu , Shin Jungpil
Published: May 2022

A rigorous filtration methodology to select the best cancer biomarker candidates using autoencoder by reversing the learning mechanism assisted by RFE and SVM.
Detection of kerosene adulteration in automobile fuel by a low-loss surface plasmon resonance (SPR) chemical sensor
Authors: Yang Lin , Shi Ying , Yi Zao , Song Xinping , Lv Jingwei , Chu Paul K. , Liu Chao
Published: May 2022

A surface plasmon resonance (SPR) chemical sensor with gold as the sensitive material is designed to detect the adulteration of petrol by kerosene. Kerosene concentration of 0% to 80% can be detected by monitoring the optical spectra.
N-Coordinated Ir single atoms anchored on carbon octahedrons for catalytic oxidation of formaldehyde under ambient conditions
Authors: Peng Shiqi , Rao Yongfang , Huang Yu , Li Tan , Li Rong , Cao Jun-ji , Lee Shuncheng
Published: May 2022

N-Coordinated Ir single atoms using N-doped carbon as a non-oxide support for formaldehyde removal under ambient conditions for the first time.
Engineering cell–substrate interactions on porous membranes for microphysiological systems
Authors: Allahyari Zahra , Gaborski Thomas R.
Published: May 2022

Pore properties of membranes used in biomimetic platforms direct cellular behavior, including adhesion, morphology, ECM formation, cell–cell interactions and differentiation.
Molecular conductors from bis(ethylenedithio)tetrathiafulvalene with tris(oxalato)gallate and tris(oxalato)iridate
Authors: Blundell Toby J. , Morritt Alexander L. , Rusbridge Elizabeth K. , Quibell Luke , Oakes Jakob , Akutsu Hiroki , Nakazawa Yasuhiro , Imajo Shusaku , Kadoya Tomofumi , Yamada Jun-ichi , Coles Simon J. , Christensen Jeppe , Martin Lee
Published: May 2022

Six new BEDT-TTF salts with tris(oxalato)gallate or -iridate anions including two new superconductors β′′-(BEDT-TTF)4[(H3O)Ga(C2O4)3]·guest (bromobenzene or iodobenzene) and a novel 5 : 1 metal–insulator β′′-(BEDT-TTF)5Ir(C2O4)3 ethanol.
Engineering plastic phase transitions via solid solutions: the case of “reordering frustration” in ionic plastic crystals of hydroxyquinuclidinium salts
Authors: Ocak Samet , Birolo Rebecca , Carì Gianluca , Bordignon Simone , Chierotti Michele R. , Braga Dario , Gobetto Roberto , Salzillo Tommaso , Venuti Elisabetta , Yaffe Omer , d'Agostino Simone
Published: May 2022

Reordering Frustration! Size and shape of the anions have been found to affect the order–disorder phase transition behavior in solid solutions-of ionic plastic crystals drastically. As a result, permanent plastic phases are obtained.
TiO2-Modulated tetra(4-carboxyphenyl)porphyrin/perylene diimide organic Z-scheme nano-heterojunctions for efficient visible-light catalytic CO2 reduction
Authors: Wang Yilin , Zhao Zhenlong , Sun Rui , Bian Ji , Zhang Ziqing , Jing Liqiang
Published: May 2022

A cascade Z-scheme nano-heterojunction of TiO2 incorporated TCPP/PDI with full spectrum response is constructed for efficient CO2 reduction, in which the energy platform TiO2 directs charge transfer by inhibiting the pathway as that in a type II one.
Controlling phase separated domains in UV-curable formulations with OH-functionalized prepolymers
Authors: Hasa Erion , Lee Tai Yeon , Allan Guymon C.
Published: May 2022

Modification of photocurable radical systems with high molecular weight prepolymers enables access to a wide array of polymer structures and properties.
Hydrogen bonds and dispersion forces serving as molecular locks for tailored Group 11 bis(amidine) complexes
Authors: Arras Janet , Ugarte Trejo Omar , Bhuvanesh Nattamai , McMillen Colin D. , Stollenz Michael
Published: May 2022

A flexible polydentate bis(amidine) ligand operates as a molecular lock for CuCl, AgCl, AuCl, and AuMes fragments by forming flexible double macrocycles with N–H⋯R–M hydrogen bonds and additional distinct weak intramolecular forces.
Formation of hierarchical platelets with morphological control by self-assembly of an azobenzene-containing liquid crystalline diblock copolymer
Authors: Sun Yao , Xu Binbin , Li Jinjie , Wang Yuqing , Li Xinxin , Lin Shaoliang
Published: May 2022

The diblock copolymer PEG-b-PAzoMA self-assembled into abundant assemblies through a heating-annealing approach, including leaf-type, macro-flower-type, and rectangular platelets by manipulating the concentration and the cooling rate of the solution.
Nanostructured micro/mesoporous graphene: removal performance of volatile organic compounds
Authors: Vo Thi To Nguyen , Lim Sun Taek , Kim Ji Hoon , Shim Gyu Hyeon , Kim Koung Moon , Kweon Boyeon , Kim Miyeon , Lee Chang Yeon , Ahn Ho Seon
Published: May 2022

An efficient strategy for the synthesis of highly porous TEGOs by an integrated thermochemical treatment. The formation of pore networks ranging from micro to mesopores, which is a remarkable reason for utilizing TEGO as a potential adsorbent.
Strain engineering of lateral heterostructures based on group-V enes (As, Sb, Bi) for infrared optoelectronic applications calculated by first principles
Authors: Liu Mengying , Li Weijie , Cheng Dan , Fang Xuan , Zhao Hongbin , Wang Dengkui , Li Jinhua , Zhai Yingjiao , Fan Jie , Wang Haizhu , Wang Xiaohua , Fang Dan , Ma Xiaohui
Published: May 2022

The band gap of the heterojunction decreases with increasing strain and becomes metallic at larger strains.
Preparation and characterization of an edible metal–organic framework/rice wine residue composite
Authors: Ba Teer , Shen Chenyang , Zhang Xiaoshan , Liu Chang-jun
Published: May 2022

An edible metal–organic framework/rice wine residue composite was made with large surface area for potential applications in drug delivery, adsorption, food processing, and others.
Robust dicopper(i) μ-boryl complexes supported by a dinucleating naphthyridine-based ligand
Authors: Ríos Pablo , See Matthew S. , Handford Rex C. , Teat Simon J. , Tilley T. Don
Published: May 2022

Cu(i) boryl species have been widely invoked as reactive intermediates in Cu-catalysed C–H borylations, but their isolation has been challenging. In this work, thermally robust dicopper(I) boryl complexes have been synthesized and studied in detail.
A warm super-Neptune around the G-dwarf star TOI-1710 revealed with TESS, SOPHIE, and HARPS-N
Authors: König P.-C. , Damasso M. , Hébrard G. , Naponiello L. , Cortés-Zuleta P. , Biazzo K. , Santos N. C. , Bonomo A. S. , Lecavelier des Étangs A. , Zeng L. , Hoyer S. , Sozzetti A. , Affer L. , Almenara J. M. , Benatti S. , Bieryla A. , Boisse I. , Bonfils X. , Boschin W. , Carmona A. , Claudi R. , Collins K. A. , Dalal S. , Deleuil M. , Delfosse X. , Demangeon O. D. S. , Desidera S. , Díaz R. F. , Forveille T. , Heidari N. , Hussain G. A. J. , Jenkins J. , Kiefer F. , Lacedelli G. , Latham D. W. , Malavolta L. , Mancini L. , Martioli E. , Micela G. , Miles-Páez P. A. , Moutou C. , Nardiello D. , Nascimbeni V. , Pinamonti M. , Piotto G. , Ricker G. , Schwarz R. P. , Seager S. , Stognone R. G. , Strøm P. A. , Vanderspek R. , Winn J. , Wittrock J.
Published: May 2022

We report the discovery and characterization of the transiting extrasolar planet TOI-1710 b. It was first identified as a promising candidate by the Transiting Exoplanet Survey Satellite. Its planetary nature was then established with SOPHIE and HARPS-N spectroscopic observations via the radial-velocity method. The stellar parameters for the host star are derived from the spectra and a joint Markov chain Monte-Carlo adjustment of the spectral energy distribution and evolutionary tracks of TOI-1710. A joint MCMC analysis of the TESS light curve and the radial-velocity evolution allows us to determine the planetary system properties. From our analysis, TOI-1710 b is found to be a massive warm super-Neptune (Mp = 28.3 ± 4.7 M⊕ and Rp = 5.34 ± 0.11 R⊕) orbiting a G5V dwarf star (Teff = 5665 ± 55 K) on a nearly circular 24.3-day orbit (e = 0.16 ± 0.08). The orbital period of this planet is close to the estimated rotation period of its host star Prot = 22.5 ± 2.0 days and it has a low Keplerian semi-amplitude K = 6.4 ± 1.0 m s−1; we thus performed additional analyses to show the robustness of the retrieved planetary parameters. With a low bulk density of 1.03 ± 0.23 g cm−3 and orbiting a bright host star (J = 8.3, V = 9.6), TOI-1710 b is one of the best targets in this mass-radius range (near the Neptunian desert) for atmospheric characterization via transmission spectroscopy, a key measurement in constraining planet formation and evolutionary models of sub-Jovian planets.
The Novodiag® Stool parasites assay, an innovative high-plex technique for fast detection of protozoa, helminths and microsporidia in stool samples: a retrospective and prospective study
Authors: Hartuis Sophie , Lavergne Rose-Anne , Nourrisson Céline , Verweij Jaco , Desoubeaux Guillaume , Lussac-Sorton Florian , Lemoine Jean-Philippe , Cateau Estelle , Jeddi Fakhri , Poirier Philippe , Le Pape Patrice , Morio Florent
Published: May 2022

Objectives: We provide the first evaluation of the CE-IVD marked Novodiag® stool parasites assay (NVD), allowing rapid and high-plex detection of 26 distinct targets, encompassing protozoans, helminths and microsporidia in stool samples. Methods: A total of 254 samples (n = 205 patients) were prospectively processed by the NVD and our routine procedure (RP). Performances of the NVD were compared with RP. Samples only positive by the NVD assay were investigated by external PCR assays. Sensitivity and specificity (Se/Sp) and time from sample receipt to results were determined for each method. The NVD was also evaluated against 77 additional samples positive for a wide range of parasites. Results: Overall positivity rate was 16.9% for RP compared with 34% using the NVD assay, and 164 samples (66%) were negative by both methods. Only 30 positive samples (12%) showed full concordance between RP and NVD. Fifty-three discordant samples were sent for external investigations. Except for Giardia intestinalis and Trichuris spp., higher Se was observed for the NVD assay for Blastocystis spp. (100% vs. 63%), Dientamoeba fragilis (100% vs. 0%), Schistosoma spp. (100% vs. 17%), and Enterobius vermicularis (100% vs. 67%) but roughly similar to RP for the remaining parasites tested. False-positive results were identified for Blastocystis spp., G. intestinalis, and Trichuris spp. using the NVD assay. The NVD mostly provides a diagnosis on the day of sample receipt compared with a mean of three days with RP. Conclusions: Besides some limitations, the NVD is a new diagnostic strategy allowing rapid and high-plex detection of gastrointestinal parasites from unpreserved stools.
André-Marie Ampère et la naissance de l'électrodynamique
Authors: Fischer Hélène
Published: May 2022

Dès 1801, Ampère a l'intuition fulgurante que magnétisme et courant électrique sont deux facettes différentes du même phénomène. En 1820, sa vie est bouleversée par l'expérience d'Œrsted, qui a observé qu'une aiguille aimantée est déviée sous l'action d'un courant électrique parcourant un fil placé à proximité.

Pour en proposer une explication, Ampère suppose avec audace l'existence de courants électriques dans les aimants. Avec frénésie, il n'a alors de cesse de concevoir de nouveaux dispositifs expérimentaux pour prouver la véracité de son hypothèse et établir la formule élémentaire et universelle qui fera de lui le « Newton de l'électricité ».
Prosolve370e on Architectural Skins
Authors: Castillo María José , Martínez Saul Marcelo , Sosa Alexa , García-Luna Romero Ana Cristina
Published: May 2022

Currently, one of the biggest problems we have in the world is pollution, which causes many health
problems for the population. Architecture is largely part of this great problem, because construction emits a lot of pollution and due to poor urban or architectural design of spaces that causes fouling to grow exponentially. As architects they must take this into account to start designing the projects, they must start designing to avoid and control contamination, either with the materials we use, the construction process or the way of designing so that users emit less amount of impurity. The objective of the architects must be to improve the quality of life of the user. It was this idea that allowed us to create this project and choose the Prosolve 37e as the main material of the project, based on the fact that we must involve sustainable alternatives to improve the quality of life of users.
A Microservice-based Infrastructure for the Academic Research on Semantic Knowledge Graphs and Derived Applications
Authors: Rommel Florian , Ziegler Wolfgang
Published: May 2022

For some time past, conceptual and technological approaches in the field of semantic knowledge graphs (ontologies) have been finding their way into the domain of technical writing, technical information management and knowledge management, with the aim of enhancing the classical classification-based methods and thereby, solving problems that either cannot or can only be solved with difficulty in form of previous approaches. As these concepts are quite new in this field, they are still subject to current research in the academic field. This paper aims at providing a microservice-based software platform to support further studies in this area. In the sense of exploratory prototyping, the platform should make it possible to research various technological and conceptual questions and to demonstrate applications derived from them, regardless of the development status of existing, proprietary productive software applications.
Role of Information Tools in Teaching and Learning
Authors: Sripavithra C K , Kirubanand V B , Paulose Joy
Published: May 2022

Human capabilities are not wholly adequate to the demands of the modern teaching and learning enterprise. Here is where we aid the information tools as a facilitator. The impression of visual and audio tools are far greater is learners in registering the learning outcomes in their memory than the passive teaching of lecturing. Dramatic changes in technology have increased the variety and accessibility of information tools. Online Google Apps, Presentation software’s, desktops and palm devices, course management tools, clickers and lecture capture tools, even flipping the classrooms are some of the latest information tools. Students are made to understand, communicate, associate and create by using the tools. This facilitates the transformation of knowledge & skills into products and solutions. Knowledge stored in the short term memory is transformed into long term memory by using the tools. Modern tools improve learning outcomes by the use of improved methodologies and better evaluation. Advantages of using the tools are better presentation by the teachers and proper understanding of the learners. Information tools facilitate interactive classes resulting in an enjoyable experience. Plenty of credible and resourceful websites makes the learners’ accessibility easier. Slow learners are able to learn at their own pace, away from classrooms. Limited involvement of teachers in using information tools is a challenge. Resource limitation and knowledge and skills of the teachers are barriers. But these are attended by proper approaches to solve the issues. Research report by ‘Institute of Multimedia Education’ in Japan proves that use of Information tools has significant and possible impact on student achievement in terms of knowledge accumulation, practice skill and presentation skill.
Recursive neural networks: recent results and applications
Authors: Zelios Andreas , Grammenos Achilleas , Papatsimouli Maria , Asimopoulos Nikolaos , Fragulis George
Published: May 2022

Neural Network’s basic principles and functions are based on the nervous system of living organisms, they aim to simulate neurons of the human brain to solve complicated real-world problems by working in a forward-only manner. A recursive Neural Network on the other hand is based on a recursive design principle over a given sequence input, to come up with a scalar assessment of the structured input. This means that is ideal for a given sequence of input data that is when processed dependent on its previous input sequence, which by default are used in various problems of our era. A common example could be devices such as Amazon Alexa, which uses speech recognition i.e., given an audio input source that receives audio signals, tries to predict logical expressions extracted from its different audio segments to form complete sentences. But RNNs do not come with no problems or difficulties. Today’s problems become more and more complex involving parameters in big data form, therefore a need for bigger and deeper RNNs is being created. This paper aims to explore these problems and ways to reduce them while also providing a description of RNN’s beneficial nature and listing different uses of the state-of-the-art RNNs and their use in different problems as those mentioned above.
Random forest classification algorithm for medical industry data
Authors: Vlachas Christodoulos , Damianos Lazaros , Gousetis Nikolaos , Mouratidis Ioannis , Kelepouris Dimitrios , Kollias Konstantinos-Filippos , Asimopoulos Nikolaos , Fragulis George F
Published: May 2022

Medical industry produces a significant portion of data whereas by adopting various Machine Learning models it can make accurate predictions about public healthcare that can be generalised. Transfer learning improves traditional machine learning by transferring the knowledge learned in one or more tasks and by using it for learning improvement in a related target task. In the current study, transfer learning with random forests was applied. Four datasets of medical interest obtained from the University of California, Irvine (UCI) Machine Learning Repository were used i.e., the BUPA-Liver Disease Dataset, the Breast Cancer Wisconsin Dataset, the Cleveland Heart Disease Dataset, and the Pima Indians Diabetes dataset. To our knowledge, there has been no study that applied Random Forests and Transfer Learning for these datasets. According to our results, our proposed method could provide significant accuracy rates in terms of diagnosing these disorders. Specifically, the classification accuracy of each dataset was similar or higher compared to the majority of similar studies that applied Random Forests. Limitations and suggestions regarding future research are also presented.
Investigating the Usefulness of Metric-based Prediction Method for Spreadsheet Fault Detection
Authors: Kunya Musa , Hamada Mohamed , Hassan Mohammed , Yusuf Ilu Saratu
Published: May 2022

The ability to predict whether a specific section of a spreadsheet is faulty or not is frequently required for the development of spreadsheet functionality. Although errors in such spreadsheets are common and can have serious consequences, today’s spreadsheet creation and management tools offer weak capabilities for defect detection, localization, and fixing. In this thesis, we proposed a method for predicting faults in spreadsheet formulas that can detect faults in non-formula cells by combining a catalog of spreadsheet metrics with modern machine learning algorithms. An examination of the individual metrics in the catalog reveals that they are suited to detecting data where a formula is expected to have flaws. In this framework, Recall Score of 99% was achieved and performance was compared with that of Melford. The result of the experiment reveals that the proposed framework outperforms Melford framework.
Digital and advanced electronic signature: the security function, especially in electronic commerce
Authors: Velentzas John , Kiriakoulis George , Broni Georgia , Kartalis Nick , Panou George , Fragulis George
Published: May 2022

The purpose of Directive 1999/93 / EC on the Community framework for electronic signatures is to facilitate the use of electronic signatures. Digital signatures are incredibly important as they prevent fraud in e-commerce transactions. A legal framework for electronic signatures is established to ensure the smooth functioning of the internal market. This article aims to interpret the European framework for digital signatures.

Member States shall at least ensure that, when issuing a certificate, the certification body is liable for any damage caused to any entity or natural or legal person reasonably based on the certificate:

(a) the accuracy, at the time of issue, of all the information contained in the recognized certificate.

(b) ensure that, at the time of issue of the certificate, the signatories identified on the recognized certificate were the holders of the signature-creation data corresponding to the signature verification data referred to or specified in the certificate;

Member States shall at least ensure that the certified provider is liable for any damage caused to any entity or natural person who reasonably relies on the certificate, unless the certifying provider proves that it did not act negligently.

Member States shall ensure that a certified service provider may indicate in a recognized certificate restrictions on the use of that certificate.

Member States shall ensure that a certification-service-provider may indicate on the recognized certificate the limits on the amount of transactions for which the certificate may be used. For all of the above, the certification service provider is not liable for damages resulting from exceeding these limits.