bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplikasi Terapi Wicara bagi Remaja Penyandang Disabilitas Intelektual Ringan
Authors: Yogasara Thedy , Stefiany Cecilia
Published: May 2019

There are more than three million people in Indonesia who have speech disorders. Speech disorders are also experienced by people with intellectual disabilities, who need speech therapy to practice their expressive speech skills. However, the current types of speech therapy, in general, are not easily accessible and require considerable cost. The purpose of this study, therefore, is to provide a speech therapy tool that can be accessed easily and requires low cost. This research designs a mobile application as a speech therapy tool for teenagers with mild intellectual disability. The design process began with the identification of user needs, followed by the design of application concepts using a design workshop. The best concept was developed into a prototype, which was then evaluated through a usability testing, using effectiveness, efficiency, learnability, memorability, and accessibility as the evaluation criteria. Based on the evaluation, the effectiveness of the application is 82.2% and its efficiency is 78.9%. Meanwhile, the learnability and memorability of the application consecutively score 80% and 94.4%. These results show that the application has a good level of accessibility. Evaluation was also conducted using the System Usability Scale (SUS) questionnaire, which resulted in a total score of 74 (acceptable). In addition, interviews were conducted to identify remaining flaws that were subsequently used as a basis for design improvement of the application.
Factors associated with exclusive breastfeeding practice in a cohort of women from Cali, Colombia
Authors: Mateus Solarte Julio Cesar , Cabrera Arana Gustavo Alonso
Published: May 2019

Introduction: Breastfeeding promotion is one of the most effective strategies to prevent child malnutrition; it reduces costs to families, health services and society. In Colombia, exclusive breastfeeding is practiced only by 10% of women.
Objective: To identify factors associated with the duration of exclusive breastfeeding.
Methods: A cohort of 438 primiparous women was followed during 6 months by means of 8 home interviews, in order to determine the duration of exclusive breastfeeding. Individual, family and health service factors were studied; and survival analysis was carried out.
Results: At 8 days, only a few more than half of the participants maintained exclusive breastfeeding; at month 6 of follow-up, this proportion was reduced to 1.4%. The duration of exclusive breastfeeding was determined by: initiation of breastfeeding in the first 4 hours after delivery (HR= 4.07, 95% CI: 0.96-16.67), selfperceived sureness for breastfeeding (HR= 1.28, 95% CI: 1.04 -1.58), positive opinion of the baby's father regarding breastfeeding (HR= 1.26, 95% CI: 1.01-1.57), and newborn weight (HR= 1.23, 95% CI: 1.00-1.53).
Conclusion: There are factors before delivery and in the immediate puerperium that determine, partially, the duration of exclusive breastfeeding.
The 2018 Censo Nacional de Población y Vivienda: the Good, the Bad and the Ugly
Authors: Santaella-Tenorio Julian
Published: May 2019

Preliminary results from the 2018 Census by the National Administrative Department of Statistics (DANE) have shown interesting news for Colombia, the major one probably being that instead of the projected 50 millions of habitants expected in 2018 in the Census 2005 projections, Colombia’s population in 2018 was 45.5 million (DANE 2018). Although, the differences in population projections vs. censuses totals have been described across countries in Latin America, Colombia seems to be a country with a major gap. Knowing how many people live in the country is important for governmental planning, public spending, and to set up goals according to public needs. Therefore, these news from the 2018 Census were received with caution among different sectors.
Can Biomechanics Research Lead to More Effective Treatment of Low Back Pain? A Point-Counterpoint Debate
Authors: Cholewicki Jacek , Breen Alan , Popovich John M. , Reeves N. Peter , Sahrmann Shirley A. , van Dillen Linda R. , Vleeming Andry , Hodges Paul W.
Published: May 2019

Synopsis

Although biomechanics plays a role in the development and perhaps the persistent or recurrent nature of low back pain (LBP), whether biomechanics alone can provide the basis for intervention is debated. Biomechanics, which refers to the mechanics of the body, including its neuromuscular control, has been studied extensively in LBP. But, can gains be made in understanding LBP by research focused on this component of biology in the multifactorial biopsychosocial problem of LBP? This commentary considers whether biomechanics research has the potential to advance treatment of LBP, and how likely it is that this research will lead to better treatment strategies. A point-counterpoint format is taken to present both sides of the argument. First, the challenges faced by an approach that considers biomechanics in isolation are presented. Next, we describe 3 models that place substantial emphasis on biomechanical factors. Finally, reactions to each point are presented as a foundation for further research and clinical practice to progress understanding of the place for biomechanics in guiding treatment of LBP. J Orthop Sports Phys Ther 2019;49(6):425–436. Epub 15 May 2019. doi:10.2519/jospt.2019.8825
The Development of Ship Number Line Media for Improving Learning Outcomes of Integers Mixed Calculated Operating in Elementary School
Authors: Mahrani Mahrani
Published: May 2019

This study aimed to describe the feasibility of a ship's number line media developed in integer operating material in class VI Elementary School, resulting in learning media in the form of a line number of vessels in integer counting operations in class VI Elementary School, describing how to apply ship number line media in operating material counting mixed integers in class VI Elementary School; and describe the improvement of student learning outcomes in calculating integer operating material after using ship number line media in class VI of Elementary School. Data collection techniques in the form of questionnaires were analyzed. The development research method or model used in this study was a 4-D model (Define, Design, Develop, Disseminate) that has been adapted, namely with the following stages of development research (1) product discovery, (2) product manufacture, (3 ) product development and (4) product dissemination. Based on the results of validation and dissemination, the shipyard media in mathematics learning developed by researchers was very feasible to use in the mathematics learning process in elementary schools or equivalent, because it had an average quality of 4.4 on a scale of 1-5 or (87%).
Sequence Specificity Despite Intrinsic Disorder: How a Disease-Associated Val/Met Polymorphism Shifts Tertiary Interactions in a Long Disordered Protein
Authors: Lohia Ruchi , Salari Reza , Brannigan Grace
Published: May 2019

The role of electrostatic interactions and mutations that change charge states in intrinsically disordered proteins (IDPs) is well-established, but many disease-associated mutations in IDPs are charge-neutral. The Val66Met single nucleotide polymorphism (SNP) encodes a hydrophobic-to-hydrophobic mutation at the midpoint of the prodomain of precursor brain-derived neurotrophic factor (BDNF), one of the earliest SNPs to be associated with neuropsychiatric disorders, for which the underlying molecular mechanism is unknown. Here we report on over 250 μs of fully-atomistic, explicit solvent, temperature replica exchange molecular dynamics simulations of the 91 residue BDNF prodomain, for both the V66 and M66 sequence.The simulations were able to correctly reproduce the location of both local and non-local secondary changes due to the Val66Met mutation when compared with NMR spectroscopy. We find that the local structure change is mediated via entropic and sequence specific effects. We show that the highly disordered prodomain can be meaningfully divided into domains based on sequence alone. Monte Carlo simulations of a self-excluding heterogeneous polymer, with monomers representing each domain, suggest the sequence would be effectively segmented by the long, highly disordered polyampholyte near the sequence midpoint. This is qualitatively consistent with observed interdomain contacts within the BDNF prodomain, although contacts between the two segments are enriched relative to the self-excluding polymer. The Val66Met mutation increases interactions across the boundary between the two segments, due in part to a specific Met-Met interaction with a Methionine in the other segment. This effect propagates to cause the non-local change in secondary structure around the second methionine, previously observed in NMR. The effect is not mediated simply via changes in inter-domain contacts but is also dependent on secondary structure formation around residue 66, indicating a mechanism for secondary structure coupling in disordered proteins.
EVALUATION OF THE ELASTIC COMPLIANCE OF THE HARDNESS TESTER IN KINETIC INDENTATION TESTS
Authors: Matyunin Vyacheslav M. , Marchenkov Artem Yu. , Abusaif Nuha , Stasenko Nikita A.
Published: May 2019

When determining the mechanical properties of materials in kinetic indentation tests using indentation diagrams, careful consideration of the elastic compliance of the device, i.e., the hardness tester, is required. The determined values of the Young's modulus of the tested material substantially depend on the reliability of the method of evaluation and accounting for the elastic compliance. Therefore, verification of the test techniques based on kinetic indentation should be carried out using the materials with the known, but rather different values of the Young's modulus. Successful experience has been gained to date in the evaluating and accounting for the elastic compliance of the device upon kinetic indentation of the materials by a diamond pyramid which is reflected in the relevant standards. However, there is no way of transferring this experience to the kinetic indentation by a steel or carbide ball without additional research and experimental verification. We proposes a technique for estimating the elastic compliance of a hardness tester using a kinetic ball indentation diagram based on the G. Hertz equation for the case of elastic contact of a ball with a plane. A linear correlation has been determined between the additional elastic deformations of the device and indentation load, which is characteristic of each device and independent on the ball diameter. The obtained dependence allows for correct consideration of the elastic compliance of the device using software applications in recording and processing the ball indentation diagrams. Experiments have been carried out to determine the hardness and the Young's modulus through ball instrumented indentation of different materials (steel, aluminum alloy, magnesium alloy, and titanium alloy) using the existing and developed methods of taking into account the elastic compliance of the device. The coincidence or proximity of the values of the Young's modulus of the same material determined from the ball indentation diagrams and sample tensile tests is considered the main criterion proving the accuracy of the technique. The advantages and shortcomings of the known and proposed procedures are discussed along with practical recommendations for their applications.
Resistance proportions for eight priority antibiotic-bacterium combinations in OECD, EU/EEA and G20 countries 2000 to 2030: a modelling study
Authors: Cravo Oliveira Hashiguchi Tiago , Ait Ouakrim Driss , Padget Michael , Cassini Alessandro , Cecchini Michele
Published: May 2019

Background

Antimicrobial resistance is widely considered an urgent global health issue due to associated mortality and disability, societal and healthcare costs.

Aim

To estimate the past, current and projected future proportion of infections resistant to treatment for eight priority antibiotic-bacterium combinations from 2000 to 2030 for 52 countries.

Methods

We collated data from a variety of sources including ResistanceMap and World Bank. Feature selection algorithms and multiple imputation were used to produce a complete historical dataset. Forecasts were derived from an ensemble of three models: exponential smoothing, linear regression and random forest. The latter two were informed by projections of antibiotic consumption, out-of-pocket medical spending, populations aged 64 years and older and under 15 years and real gross domestic product. We incorporated three types of uncertainty, producing 150 estimates for each country-antibiotic-bacterium-year.

Results

Average resistance proportions across antibiotic-bacterium combinations could grow moderately from 17% to 18% within the Organisation for Economic Co-operation and Development (OECD; growth in 64% of uncertainty sets), from 18% to 19% in the European Union/European Economic Area (EU/EEA; growth in 87% of uncertainty sets) and from 29% to 31% in Group of Twenty (G20) countries (growth in 62% of uncertainty sets) between 2015 and 2030. There is broad heterogeneity in levels and rates of change across countries and antibiotic-bacterium combinations from 2000 to 2030.

Conclusion

If current trends continue, resistance proportions are projected to marginally increase in the coming years. The estimates indicate there is significant heterogeneity in resistance proportions across countries and antibiotic-bacterium combinations.
Use of the moving epidemic method (MEM) to assess national surveillance data for respiratory syncytial virus (RSV) in the Netherlands, 2005 to 2017
Authors: Vos Laura M , Teirlinck Anne C , Lozano José E , Vega Tomás , Donker Gé A , Hoepelman Andy IM , Bont Louis J , Oosterheert Jan Jelrik , Meijer Adam
Published: May 2019

Background

To control respiratory syncytial virus (RSV), which causes acute respiratory infections, data and methods to assess its epidemiology are important.

Aim

We sought to describe RSV seasonality, affected age groups and RSV-type distribution over 12 consecutive seasons in the Netherlands, as well as to validate the moving epidemic method (MEM) for monitoring RSV epidemics.

Methods

We used 2005−17 laboratory surveillance data and sentinel data. For RSV seasonality evaluation, epidemic thresholds (i) at 1.2% of the cumulative number of RSV-positive patients per season and (ii) at 20 detections per week (for laboratory data) were employed. We also assessed MEM thresholds.

Results

In laboratory data RSV was reported 25,491 times (no denominator). In sentinel data 5.6% (767/13,577) of specimens tested RSV positive. Over 12 seasons, sentinel data showed percentage increases of RSV positive samples. The average epidemic length was 18.0 weeks (95% confidence intervals (CI):  16.3–19.7) and 16.5 weeks (95% CI: 14.0–18.0) for laboratory and sentinel data, respectively. Epidemics started on average in week 46 (95% CI: 45–48) and 47 (95% CI:  46–49), respectively. The peak was on average in the first week of January in both datasets. MEM showed similar results to the other methods. RSV incidence was highest in youngest (0–1 and >1–2 years) and oldest (>65–75 and > 75 years) age groups, with age distribution remaining stable over time. RSV-type dominance alternated every one or two seasons.

Conclusions

Our findings provide baseline information for immunisation advisory groups. The possibility of employing MEM to monitor RSV epidemics allows prospective, nearly real-time use of surveillance data.
Measures to control protracted large Lassa fever outbreak in Nigeria, 1 January to 28 April 2019
Authors: Dan-Nwafor Chioma C. , Furuse Yuki , Ilori Elsie A , Ipadeola Oladipupo , Akabike Kachikwulu O , Ahumibe Anthony , Ukponu Winifred , Bakare Lawal , Okwor Tochi J , Joseph Gbenga , Mba Nwando G , Akano Adejoke , Olayinka Adebola T , Okoli Ihekerenma , Okea Rita A , Makava Favour , Ugbogulu Nkem , Oladele Saliu , Namara Geoffrey , Muwanguzi Esther N , Naidoo Dhamari , Mutbam Samuel K , Okudo Ifeanyi , Woldetsadik Solomon F , Lasuba Clement LP , Ihekweazu Chikwe
Published: May 2019

Lassa fever cases have increased in Nigeria since 2016 with the highest number, 633 cases, reported in 2018. From 1 January to 28 April 2019, 554 laboratory-confirmed cases including 124 deaths were reported in 21 states in Nigeria. A public health emergency was declared on 22 January by the Nigeria Centre for Disease Control. We describe the various outbreak responses that have been implemented, including establishment of emergency thresholds and guidelines for case management.
Model Pembelajaran Program Ekstrakurikuler Bahasa Arab dan Implementasinya di Madrasah Aliyah Pesantren
Authors: Zulqarnain Ibnu , Rohman Muhammad Muti'ur , Maftuhah Maftuhah , Arifa Zakiyah
Published: May 2019

Pesantren based madrasah makes the Arabic language as one of the essential things to be mastered by their students. Madrasah runs several Arabic programs to improve students attention and proficiency of Arabic language through extracurricular activities outside the classroom that aim to enrich knowledge and channel students interest and talents. However, among these various activities, many of it do not operate well because of lack of skills. The purpose of this study is to describe the implementation of extracurricular programs in MA Pesantren Nurul Ulum and the language learning models used. The research used the descriptive qualitative method. The data sources of this research are the instructors in the Arabic extracurricular program, the location, files and photos of activities that carried out by interview, observation, and documentation. The results of this study are the implementation of extracurricular programs in MA Pesantren Nurul Ulum by using various language learning models following the objectives of the activities; cooperative models in Arabic Olympics extracurricular, Taqdimul Qishshah, and Khithabah, communicative-eclectic and quantum models in quiz extracurricular. Diverse learning models make the learning process more varied for teachers and students while train student competencies. Then it should be realized as a whole in Arabic language education.
Mustawiyat al-Dirasah al-Arabiyah Li Aghrad Ammah: al-Marhalah al-Ibtidaiyah Wa al-Mutawasithah Wa al-Muqaddimah Mustawiyat al-Ada' al-Mukhtalifah Fi Mumarisah al-Lughah Bima Fiha Min Jawanib Ma'rifiyah Au Wajdaniyah Au Nafs Harkiyah
Authors: Yaqin Muhammad Ainul
Published: May 2019

This research discusses the Arab study levels for general purposes and from the perspective of cognitive and emotional intelligence. This research is phenomenal in Indonesia and is one of the qualitative approach of the genus phenomenon. That the levels are divided into three sections I, which is special for the new learners who participate in the programs of teaching the Arabic language, like any language of teaching to non-native speakers without knowledge of the language or familiarity with them. The conversation at this level is limited to the memorization of these students models of the correct Arab conversation and its topics are usually specific. There is no way to diversify the attitudes of the student. Level Two the highest level of precedent The conversation at this level usually revolves around broader topics, more complex issues, and more abstract consensus. At this level, the conversation revolves around topics and ideas. Students study in specific texts, from which they draw ideas woven around them, issues they discuss, and simple problems that exchange views. Level Three This represents the highest level of conversation in the teaching of Arabic as a second language. At this level, learners are expected to practice conversation in the sense that we have taken for conversation in that it is an automatic free discussion on a given subject and two individuals conversing. The student at this level usually has extensive linguistic experience and the ability to use syntax correctly. Understanding different versions of one expression and putting each of them in the right place.
Optimalisasi Produk Emping Melinjo Guna Meningkatkan Nilai Tambah Bagi Masyarakat Kampung Cipanas Baru Desa Mancak Kabupaten Serang
Authors: Sunaryo Deni , Sunaryo Deni
Published: May 2019

Penduduk Desa Mancak berjumlah 4278 jiwa, yang terdiri dari laki-laki 2168 jiwa dan perempuan 2110 jiwa, umumnya penduduk bekerja di ladang dan buruh kasar serta pedagang, sedangkan untuk Ibu rumah tangga hanya membantu pekerjaan rumah.Luas Wilayah Desa Mancak 538.8 Ha dimana 64% nya adalah Pertanian dan perkebunan. Hasil utama alam dan ciri khas dari Desa Mancak adalah melinjo, kelapa dan bambu, pada pengabdian ini difokuskan pada optimalisasi pengembangan produk hasil olahan emping melinjo disebabkan sangat potensial untuk ditingkatkan nilai daya guna serta nilai tambah atas produk hasil olahan melinjo tersebut sehingga hasil produk olahan tidak semata hanya emping melinjo alami saja, namun mempunyai alternatif variasi produk hasil olahan emping melinjo dengan berbagai aneka macam tersebut.Tujuan pengabdian yang dilakukan adalah menjalankan fungsi Tridarma Perguruan Tinggi, metode yang digunakan adalah memberikan supervisi dan tahapan dalam membuat inovasi produk sampai dengan siap jual sesuai dengan beberapa segment pasar dan pada penelitian ini difokuskan pada satu kampung yaitu kampung Cipanas Baru Desa Mancak Kecamatan Mancak Kabupaten Serang.Hasil pengabdian ini memberikan manfaat bagi penduduk di Kampung Cipanas baru Desa Mancak guna meningkatakan nilai tambah produk dan menambah pendapatan bagi keluarga. Dan bagi pengabdi dalam menjalankan fungsi Tridarma Perguruan Tinggi.
PENJAJA SEKS MELALUI MEDIA SOSIAL DALAM ASPEK HUKUM PIDANA
Authors: Ningtias Ayu Dian
Published: May 2019

Penjaja seks melalui media social, dalam kini menjadi permasalahan criminal yang banyak dijumpai melaui media social, Instagram, WhatsApp, Facebook, dll. Bagaimana aspek hokum pidana dalam kejahatan cyber berupa penjaja seks komersial melalui media social, menjadi focus dalam penelitian ini. Dengan metode penelitian yuridis normative diperoleh hasil Analisa berdasar pada pendekatan perundang-undangan dan pendekatan konseptual, Ketentuan pengaturan tindak pidana prostitusi online di Indonesia diatur dalam beberapa Undang-Undang yang bersifat sektoral dan kasuistis. Undang-undang No 19 tahun 2016  dan 44 Tahun 2008 tentang Pornografi merupakan Undang-Undang yang paling komprehensif dalam mengatur ketentuan tentang prostitusi online karena mengatur tentang dokumen elektronik atau informasi elekronik sebagai media dalam prostitusi online.
Interactive modelling of buildings in Google Earth and GIS: A 3D tool for Urban Planning (Tunjuk Island, Indonesia)
Authors: Lubis Muhammad Zainuddin , Anurogo Wenang , Gustin Oktavianto , . Andi , Hanafi Aditya , Timbang Dirgan , Rizki Fajar , Saragih Diaz Ariwinata , Kartini Indah Ira , Panjaitan Hana Cyintia , Yanti Marisa Tri , Taki Herika Muhamad
Published: May 2019

3D modelling of buildings in Google Earth in Batam city, Indonesia is very important for knowledge about facility, infrastructure, and others.Three-dimensional (3D) visualisations are an interesting method for representing model outcomes. This research In Tunjuk island with coordinate, at Latitude: 0.984123°, and Longitude: 104.225606°, with technical terms, there are two alternative routes for implementation, and they both share the same starting stage. In (Figure 5) visible visual measurements of the master plan that has been made has a length 141.99 metre and width 54.25 metre with location at Latitude 0.984593° and Longitude 104.228073°. In (Figure 5) visible visual measurements of the master plan that has been made has a length 92.96 metre and width 135.46  metre with location at Latitude 0.984593° and Longitude 104.228073°. This paper presented a rapid visualisation tool for supporting the joint decision making in evaluation of design/renewal proposals in Batam City, Tunjuk Island, Indonesia. 3D building using Google Earth (GE) and combaining Geographic Information System (GIS) system be done officially on a sampling or auditing basis by a professional body or by researchers, or it could be done by volunteers and user groups.
Analysis Of Aerial Photography With Drone Type Fixed Wing In Kotabaru, Lampung
Authors: Suroso Indreswari , Irmawan Erwhin
Published: May 2019

In the world of photography is very closely related to the unmanned aerial vehicle called drones. Drones mounted camera so that the plane is pilot controlled from the mainland. Photography results were seen by the pilot after the drone aircraft landed. Drones are unmanned drones that are controlled remotely. Unmanned Aerial Vehicle (UAV), is a flying machine that operates with remote control by the pilot. Methode for this research are preparation assembly of drone, planning altitude flying, testing on ground, camera of calibration, air capture, result of aerial photos and analysis of result aerial photos. There are two types of drones, multicopter and fixed wing. Fixed wing  has an airplane like shape with a wing system. Fixed wing use bettery 4000 mAh . Fixed wing drone in this research used   mapping in  This drone has a load ability of 1 kg and operational time is used approximately 30 minutes for an areas 20 to 50 hectares with a height of 100 m  to 200 m and payload 1 kg  above ground level. The aerial photographs in Kotabaru produce excellent aerial photographs that can help mapping the local government in the Kotabaru region.
Синтез и скрининг противовирусной активности C5-C6-производных 1,3-диметил-5-фторурацила и 5-фторурацила
Authors: Черникова Инна Борисовна , Хурсан С. Л. , Еропкин М. Ю. , Юнусов М. С.
Published: May 2019

Хлорированием молекулярным хлором 5-фторурацила и 1,3-диметил-5-фторурацила в различных спиртах синтезированы 5-фтор-5-хлор-6-алкоксипроизводные пиримидинового ряда, проведен скрининг противовирусной активности. Обнаружена высокая противовирусная активность 5-фтор-5-хлор-6-гидрокси-5,6-дигидроурацила для РС-вируса и вирусов гриппа человека A/H3N2 и A/H1N1pdm09.
Перспективы использования интраназального введения для доставки нейропептидов в головной мозг
Authors: Шевченко Константин Валерьевич , Нагаев Игорь Юлианович , Андреева Людмила Александровна , Шевченко Валерий Павлович , Мясоедов Николай Федорович
Published: May 2019

Преимуществами интраназального метода введения (ИМВ) лекарственных препаратов является неинвазивность, безболезненность, простота и удобство применения. Показаны основные подходы, связанные с решением задач по эффективной доставке в мозг пептидов через слизистую носа с учетом особенности анатомии и физиологии носовой полости. ИМВ позволяет обойти гематоэнцефалический барьер, но сталкивается с проблемой протеолиза пептидов под действием компонентов слизи обонятельного эпителия — с ферментативным барьером. В качестве реперных пептидов для экспериментов in vivo использовали Pro-Gly-Pro, Pro-Gly-Pro-Leu, семакс, селанк. В плазме крови крыс максимальное содержание Pro-Gly-Pro-Leu, семакса, Pro-Gly-Pro и селанка составило 0,54, 1,69, 1,30 и 1,04 % от введенного количества меченого пептида. В мозге крыс соответствующие значения для Pro-Gly-Pro-Leu, семакса, Pro-Gly-Pro и селанка достигали 0,0013, 0,13, 0,04 и 0,16 %. Для уменьшения протеолиза семакса при преодолении им ферментативного барьера в нем заменяли метионин на аланин, глицин, треонин и триптофан. Для повышения устойчивости семакса использовали также липосомы и ацетилирование N-концевой аминокислоты. Показано, что использование N-ацетил-семакса наиболее перспективно. Для экспериментов in vitro использовали лейцинаминопептидазу (в инкубационной среде через 60 мин содержалось 12,6 % семакса), дипептидную пептидазу (95,4 %), карбоксипептидазу B (96,8 %) и Y (51,0 %), ферменты назальной слизи (4,0 %), микросомальной фракции мозга (9,0 %) и плазму крови (0,7 %) крыс. При протеолизе семакса в основном образуются His-Phe-Pro-Gly-Pro, Phe-Pro-Gly-Pro, Pro-Gly-Pro.
Синтез и фармакологические свойства N-децилтропина (ИЭМ-1556) в сравнении с селективным блокатором н-холинорецепторов трет-бутилдециламмонием (ИЭМ-1678)
Authors: Гмиро Валерий Евгеньевич , Сердюк С. Е.
Published: May 2019

По совокупности свойств N-децилтропин (ИЭМ-1556) обладает существенными преимуществами перед своим прототипом, селективным блокатором н-холинорецепторов трет-бутилдециламмонием (ИЭМ-1678), так как значительно превосходит ИЭМ-1678 по противосудорожной, противопаркинсонической, антидепрессивной и анальгезирующей активности, а также имеет в 2,8 раза более высокий, чем у ИЭМ-1678, терапевтический индекс. Более высокая фармакологическая активность и низкая токсичность ИЭМ-1556 объясняется тем, что ИЭМ-1556 не только блокирует н-холинорецепторы, но и дополнительно стимулирует субдиафрагмальные вагусные афференты.
Синтез и противосудорожная активность 4-амино-3-нитро-1-тиокумаринов и 4-амино-3-нитрохинолин-2-онов
Authors: Мокров Григорий Владимирович , Воронина Татьяна Александровна , Литвинова Светлана Александровна , Ковалев Иван Георгиевич , Неробкова Любовь Николаевна , Дурнев Андрей Дмитриевич , Гудашева Татьяна Александровна , Середенин Сергей Борисович
Published: May 2019

Представлены синтез и результаты исследований противосудорожной активности оригинальных соединений, относящихся к классам тиокумаринов и хинолин-2-онов. Проведен анализ связи структура — действие в ряду синтезированных соединений и ранее полученных производных кумарина. В опытах на мышах наибольшая противосудорожная активность выявлена у метилового эфира N-(3-нитро-2-оксо-1,2-дигидрохинолин-4-ил)-4-аминомасляной кислоты (3а) в дозе 12,5 мг/кг (внутрибрюшинно).
Penggunaan Media Geometri untuk Meningkatkan Kreativitas Anak dalam Menciptakan Bentuk
Authors: Roostin Erna
Published: May 2019

Penelitian ini bertujuan untuk mengetahui dan mendapatkan gambaran mengenai peningkatan kreativitas anak dalam menciptakan bentuk  di kelompok belajar Bina Insan Mandiri  Kecamatan Cimalaka  Kabupaten Sumedang tahun pelajaran 2017/2018 dalam  kegiatan bermain bentuk-bentuk geometri.  Metode yang digunakan adalah Penelitian Tindakan Kelas (PTK), teknik pengumpulan data yang dilakukan adalah Observasi dan Unjuk Kerja. Analisis data menggunakan deskriptif kualitatif. Hasil penelitian menunjukan bahwa dalam penggunaan media geometri untuk  meningkatkan kreativitas anak dalam menciptakan bentuk dalam keterperincian dengan dukungan aspek keceriaan, kreatif, disiplin, antusias, dan mandiri.  Peningkatan perilaku  anak dalam aspek kreatif berkatagori baik pada data awal 27%, siklus I 47%, siklus II 67%, dan siklus III 87% dengan grafik meningkat.  Peningkatan kreativitas anak  dalam menciptakan 2 macam bentuk geometri menjadi bentuk yang baru pada katagori anak berkembang sangat baik  dengan grafik meningkat terlihat pada  data awal sebesar 40%, siklus I sebesar 53%,  pada siklus II sebesar 73%, dan terus meningkat pada siklus III sebesar 93%.
Moral Injury Among Professionals in K–12 Education
Authors: Sugrue Erin P.
Published: May 2019

This article presents the quantitative portion of a mixed methods study of moral injury among professionals in K–12 public education. Using a cross-sectional correlational survey design, 218 licensed K–12 professionals from 68 schools in one urban school district in the Midwest completed an on-line survey that included measures of moral injury and emotional and behavioral correlates. The K–12 professionals exhibited levels of moral injury similar to those experienced by military veterans. Correlational analyses found that experiences of moral injury were associated with feelings of guilt, troubled conscience, burnout, and the intention to leave one’s job. Linear regression analyses demonstrated that professionals working in high-poverty, racially segregated schools were significantly more likely to endorse experiences of moral injury. These findings reinforce the significance of the intersectionality of race and class in reproducing oppressive and immoral educational practices and outcomes. A deeper understanding of and greater attention to potential sources of moral injury is critical in order to foster a more just and ethical education system.
PERBANDINGAN KEKUATAN PEMBUKTIAN AKTA OTENTIK DALAM PERKARA PERDATA DAN PERKARA PIDANA
Authors: Stefin Adie Marthin
Published: May 2019

Authentic deeds as perfect evidence (volledig bewijskracht) and binding (bindende bewijskracht), so that authentic deeds can stand alone without the support of other evidence. This study analyzed the differences in the power of authentic authentic deeds in civil and criminal cases and the power to prove authentic deeds in criminal cases still requires other evidence to determine their perfection. The research method used normative legal research while the problem approach is carried out using a legal approach and conceptual approach. The results of the study indicate that the evidentiary law is not an orderly system. The strength or weakness of evidence in evidence depends on the evidentiary parameters used in each court, both civil and criminal. The difference in the parameters in proof is what distinguishes the power of the law of authentic proof of deed in criminal and civil cases. Regarding the value of authentic deed perfection in criminal cases, the authors conclude that, the power of proof of authentic deed is not of perfect value and does not bind judges, so authentic deeds in criminal cases cannot stand alone and require other evidence for judges in making decisions
KEPASTIAN HUKUM DALAM KEPEMILIKAN SATUAN RUMAH SUSUN
Authors: Cholifah Hestining
Published: May 2019

This study aimed to determine the legal relationship of the parties in the Agreement on Sale and Purchase (PPJB) Flats and legal protection for buyers of Flat Housing Unit if the seller / developer defaults. This research is a normative juridical research, namely research on laws that are in the legislation in force in Indonesia. This research focused on document research or literature which essentially looks for theories, views that have correlation and are relevant to the problems to be studied. The results of the study indicated that the legal relationship between the parties in the PPJB starts from the signing of the PPJB, so that a legal relationship is established which creates the rights and obligations of each party. Legal protection for buyers of Flat Units if the seller / developer defaults is through arbitration at the cost of joint responsibility by the parties. It meant that if there is a dispute between the parties regarding the sale and purchase agreement unit apartment, the settlement is not through public court or litigation, but the solution is taken through arbitration (non litigation)
PENGEMBANGAN SKALA MODAL SOSIAL PADA REMAJA
Authors: Selviana
Published: May 2019

Adolescents are surrounded by social environment in their daily life which becomes their social capital. In this study, the social capital includes significant people in adolescents’ life, such as: parents, teachers, and friends, from which the measurement of adolescent social capital is based upon. Respondents in this study consisted of 250 adolescents, of which 46 percent were men. The results of psychometric tests demonstrated a good validity and reliability of the developed scale through internal consistency and construct validity testing. The scale was proficient in measuring the similar constructs of social capital: social interaction, trust, and shared vision. Given the good psychometric properties, the developed scale is reliable to be used to measure social capital for adolescents.
‘Average intellectuals’ and the Middle ages : an introduction with translation, and apparatus.
Authors: Akmut Camille
Published: May 2019

A collection of previously released articles, that belonged and weredone together. (an intellectual triptych)
The bayesvl R package. Hướng dẫn sử dụng v0.8
Authors: Vuong Quan-Hoang , La Viet-Phuong
Published: May 2019

Hướng dẫn sử dụng phần mềm bayesvl phiên bản v0.8 trên R.
Design and analysis of the porous ZrO2/(ZrO2+Ni) ceramic joint with load bearing-heat insulation integration
Authors: Zhou Wenbin
Published: May 2019

The joining of ceramics with metals is widely used in aerospace engineering where high strength and excellent heat insulation materials are desired. In this paper, a new multifunctional bolted joint with load bearing-heat insulation integration is prepared with porous ZrO2/(ZrO2+Ni) sandwich ceramics. Double-shear behavior of the bolted joint connecting C/SiC plates is analyzed by ABAQUS codes. It is found that shearing damage occurs at shearing faces of the bolt, the shearing failure faces are layered rather than smooth. To improve its shearing strength, we introduce the shear band (ZrO2+V%Ni of thickness h) to its shearing faces. Results show that the shear band can improve the shearing strength and slow down the attenuation of load bearing capacity after reaching the shearing strength, without obviously increasing the thermal conductivity. An optimal structural design is performed and proper shear band is defined to balance the shearing strength and heat insulation performance of the ceramic joint.
Pengaruh Sifat Matematika terhadap Pembelajaran
Authors: Yuliyahya Lita , Setiawan Adib Rifqi
Published: May 2019

Penelitian deskriptif ini mengurai pengaruh sifat matematika terhadap pembelajaran di sekolah. Sifat Matematika secara umum ialah: (1) memiliki objek kajian yang abstrak; (2) mengacu kepada kesepakatan; (3) berpola pikir deduktif; (4) konsisten dalam sistemnya; (5) memiliki simbol yang tak bermakna; serta (6) memperhatikan semesta pembicaraan. Matematika yang dipelajari di sekolah adalah matematika yang materinya dipilih agar mudah dialihfungsikan kegunanannya dalam keseharian. Letak pengaruh keenam sifat matematika terhadap pembelajaran ialah di: (1) urutan penyajian konten; (2) penggunaan media; (3) keluwesan dalam menerapkan pola pikir induktif; (4) tahap pengenalan semesta pembicaraan; serta (5) kaitan antar konten. Luaran penelitian dapat menjadi bahan untuk mengembangkan pembelajaran dengan ragam model yang selaras dengan keadaan siswa.
Artikel Administrasi Sarana dan Prasarana Pendidikan
Authors: Mutiara Rani Faras , Afriansyah Hade
Published: May 2019

Educational facilities are all facilities that are directly used in the process teaching and learning,both moving and ummoving with the aim of being the achievement of education can run smoothly,regularly effectively and effciently
Pengembangan Supervisi Klinis Untuk Meningkatkan Keterampilan Dasar Mengajar Guru Dalam Dunia Pendidikan
Authors: SUSANTI MELLA
Published: May 2019

Kualitas pembelajaran di Indonesia belum memenuhi kualitas atau mutu yang diharapkan, banyak terjadi permasalahan yang menghambat terjadinya proses pembelajaran dengan baik. Baik dari segi kualitas guru, sarana dan prasarana, peseta didik itu sendiri dan sebagainya. untuk itu supervisi pendidikan memegang peran penting dalam masalah tersebut, dan akhirnya menghasilkan prestasi dan mutu yang baik didunia pendidikan di indonesia. Dalam hal ini guru sangat berperan penting dalam peningkatan kualitas pembelajaran dan pengembangan supervisi klinis untuk meningkat ketermpilan dasar mengajar guru sangat dilakukan dengan baik.
Supervisi Pendidikan
Authors: Putri Futari Meidia
Published: May 2019

Artikel ini bertujuan untuk mengetahui bagaimana Supervisi pendidikan memegang peranan penting dalam meningkatkan kualitas pembelajaran guru yang pada akhirnya menghasilkan prestasi belajar siswa yang tinggi,sehingga bias bersaing di tingkat nasional dan internasional.Peningkatan kualitas pembelajaran perlu dilakukan secara berkesinambungan seiring perkembangan ilmu pengetahuan, teknologi serta social ekonomi dan budaya masyarakat. Dengan melakukan pendekatan supervise dan pendekatan pelatihan dapat meningkatkan profesionalisme guru yang bermuara pada tingginya prestasi belajar siswa.
Keterampilan Berbicara Ceramah
Authors: Akbar Muhammad Rizal
Published: May 2019

Keterampilan berbahasa merupakan suatu keterampilan yang harus dimiliki oleh seseorang untuk menunjang proses interaksi antara sesama individu agar dapat mencapai tujuan yang diinginkan. Adapun keterampilan berbahasa dijabarkan menjadi beberapa jenis yakni keterampilan membaca, menulis, menyimak, dan berbicara. Pada pembahasan kali ini, lebih dimuat keterampilan berbahasa khususnya berbicara, karena ketika dalam berbicara, seseorang yang melakukan interaksi dituntut harus lebih unggul dalam menyampaikan materi atau informasi kepada lawan bicara, dengan maksud tercapainya informasi yang akan disampaikan. Salah satu kegiatan berbicara dapat diimplementasikan dalam kegiatan ceramah yaitu ketika guru berbicara di depan siswanya ataupun khotbah jumat yang dilakukan oleh pemeluk agama Islam pada setiap hari Jumat. Bedasarkan hasil penelitian dengan mengamati secara langsung kegiatan ceramah tersebut, terdapat beberapa kelemahan dan kelebihan yang dihadapi ketika berbicara di depan umum.Kata Kunci: Keterampilan Berbahasa, Berbicara, Khotbah
Menulis: Karya Tulis Ilmiah
Authors: Wulansari Keken
Published: May 2019

Keterampilan berbahasa Indonesia meliputi menyimak, berbicara, membaca, dan menulis. Keterampilan menulis merupakan keterampilan yang dianggap paling tinggi tingkatannya jika dibandingkan dengan ketiga keterampilan lainnya. Menulis merupakan suatu keterampilan untuk menuangkan ide, gagasan serta ekspresi dengan bahasa sebagai medianya. Menulis juga dapat dikatakan sebagai media komunikasi karena dengan tulisan sebagai mediannya seseorang dapat bercerita dan berbagi pengalaman kepada orang lain. Semua orang dapat melakukan kegiatan menulis, untuk mengisi waktu senggang atau memang sebuah kebutuhan. Tak luput bagi mahasiswa, mahasiswa melaksanakan kegiatan atau penerapan keterampilan menulis dalam seluruh proses pembelajaran selama di perguruan tinggi. Pada setiap semester mahasiswa harus membuat makalah pada setiap akhir proses pembelajaran mahasiswa juga harus menulis skripsi, tesis maupun disertasi.
A gifted SNARC? Directional spatial-numerical associations in gifted children with high level math skills do not differ from controls
Authors: He Yunfeng , Nuerk Hans-Christoph , Derksen Alexander , Shi Jiannong , Zhou Xinlin , Cipora Krzysztof
Published: May 2019

The SNARC (Spatial-Numerical Association of Response Codes) effect (i.e., a tendency to associate small / large magnitude numbers with the left / right hand side), is prevalent across the whole lifespan. Because the ability to relate numbers to space has been viewed as a cornerstone in the development of mathematical skills, the relationship between the SNARC effect and math skill has been frequently examined. The results remain largely inconsistent. Studies testing groups of people with very low or very high skill levels in math sometimes found relationships between SNARC and math skill. So far, however, studies testing such extreme math skill level groups were mostly investigating the SNARC effect in individuals revealing math difficulties. Groups with above average math skills remain understudied, especially in regard to children. Here, we investigate the SNARC effect in gifted children, as compared to normally developing children (overall n = 165). Frequentist and Bayesian analysis suggested that the groups did not differ from each other in the SNARC effect. These results are the first to provide evidence for the SNARC effect in a relatively large sample of gifted (and mathematically highly skilled) children. In sum, our study provides another piece of evidence for no direct link between the SNARC effect and mathematical ability in childhood.
Ubiquitous enhancement of spatial hearing in congenitally blind people
Authors: Battal Ceren , Occelli Valeria , Bertonati Giorgia , Falagiarda Federica , Collignon Olivier
Published: May 2019

Vision is thought to scaffold the development of spatial abilities in the other senses. How does spatial hearing therefore develop in people lacking visual experience? We comprehensively addressed this question by investigating auditory localization abilities in 17 congenitally blind and 17 sighted individuals using a psychophysical minimum audible angle task exempt of sensori-motor confounds. Participants were asked to compare the relative position of two sound sources located in central and peripheral, horizontal and vertical, frontal and rear spaces. We observed unequivocal enhancement of spatial hearing abilities in congenitally blind people, irrespective of the field of space that is assessed. Our results are conclusive in demonstrating that visual experience is not a mandatory prerequisite for developing optimal spatial hearing abilities and that, in striking contrast, the lack of vision leads to ubiquitous enhancement of auditory spatial skills.
An Experimental Study of Recommendation Algorithms for Tailored Health Communication
Authors: Kim hyun Suk , Yang Sijia , Kim Minji , Hemenway Brett , Ungar Lyle H , CAPPELLA JOSEPH NICHOLAS
Published: May 2019

Recommendation algorithms are widely used in online cultural markets to provide personalized suggestions for products like books and movies. At the heart of the commercial success of recommendation algorithms is their ability to make an accurate prediction of a target person’s preferences for previously unseen items. Can these algorithms also be used to predict which health messages an individual will evaluate favorably, and thereby provide effective tailored communication to the person? Although there is evidence that message tailoring enhances persuasion, little research has examined the effectiveness of recommendation algorithms for tailored health interventions aimed at promoting behavior change. We developed a message tailoring algorithm to select smoking-related public service announcements (PSAs) for smokers, and experimentally test its effectiveness in predicting a target smoker’s evaluations of PSAs and encouraging smoking cessation. The tailoring algorithm was constructed using multiple levels of data on smokers’ PSA rating history, individual differences, content features of the PSAs, and other smokers’ PSA ratings. We conducted a longitudinal online experiment to examine its efficacy in comparison to two non-tailored methods: “best in show” (choosing messages most preferred by other smokers) and “off the shelf” (random selection from eligible ads). The results showed that the tailoring algorithm produced more accurate predictions of smokers’ message evaluations than the simple-average method used for the “best in show” approach. Smokers who viewed PSAs recommended by the tailoring algorithm were more likely than those receiving a random set to evaluate the PSAs favorably and quit smoking. There was no significant difference between the “best in show” and “off the shelf” methods in message assessment and quitting behavior.