bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytisus scoparius and Ulex europaeus Produce Volatile Organic Compounds with Powerful Synergistic Herbicidal Effects
Authors: Pardo-Muras María , G. Puig Carolina , Pedrol Nuria
Published: December 2019

New herbicides based on natural products are claimed to address weed resistance and environmental concerns related to synthetic herbicides. In our previous studies, certain volatile organic compounds (VOCs) produced by Ulex europaeus and Cytisus scoparius were argued to be responsible for the phytotoxicity of both shrub species. Interactions among VOCs were hypothesized to explain the inconsistency between the effects of the identified pure compounds and those naturally emitted from fresh plant material. In this work, eugenol, verbenone, terpinen-4-ol, α-terpineol, and linalool were assayed as binary mixtures of Amaranthus retroflexus and Digitaria sanguinalis. Powerful synergistic inhibitory effects were revealed for germination and early growth. Only 3.1 ppm of verbenone was enough to inhibit A. retroflexus germination when paired to other VOCs. Eugenol was capable of exacerbating the effects of terpinen-4-ol on A. retroflexus, even though it was innocuous when acting alone at 12.5 ppm. The verbenone and linalool pair produced very significant synergistic effects in terms of D. sanguinalis germination. The synergistic effects were predominantly irreversible for D. sanguinalis, since seeds exposed to paired VOCs were unable to recover their germination capacity after removing the phytotoxins or produced damaged seedlings. Both shrub species have been revealed as sources of natural herbicide molecules, with promising synergistic modes of action that deserve to be studied in depth.
Covalent Inhibition of the Histamine H3 Receptor
Authors: Wágner Gábor , Mocking Tamara A. M. , Kooistra Albert J. , Slynko Inna , Ábrányi-Balogh Péter , Keserű György M. , Wijtmans Maikel , Vischer Henry F. , de Esch Iwan J. P. , Leurs Rob
Published: December 2019

Covalent binding of G protein-coupled receptors by small molecules is a useful approach for better understanding of the structure and function of these proteins. We designed, synthesized and characterized a series of 6 potential covalent ligands for the histamine H3 receptor (H3R). Starting from a 2-amino-pyrimidine scaffold, optimization of anchor moiety and warhead followed by fine-tuning of the required reactivity via scaffold hopping resulted in the isothiocyanate H3R ligand 44. It shows high reactivity toward glutathione combined with appropriate stability in water and reacts selectively with the cysteine sidechain in a model nonapeptide equipped with nucleophilic residues. The covalent interaction of 44 with H3R was validated with washout experiments and leads to inverse agonism on H3R. Irreversible binder 44 (VUF15662) may serve as a useful tool compound to stabilize the inactive H3R conformation and to study the consequences of prolonged inhibition of the H3R.
Volatile Fatty Acids Production from Microalgae Biomass: Anaerobic Digester Performance and Population Dynamics during Stable Conditions, Starvation, and Process Recovery
Authors: Magdalena Jose Antonio , Tomás-Pejó Elia , González-Fernández Cristina
Published: December 2019

Disturbances in anaerobic digestion (AD) negatively impact the overall reactor performance. These adverse effects have been widely investigated for methane generation. However, AD recently appeared as a potential technology to obtain volatile fatty acids (VFAs) and thus, the impact of process disturbances must be evaluated. In this sense, microbial response towards a starvation period of two weeks was investigated resulting in a conversion of organic matter into VFAs of 0.39 ± 0.03 COD-VFAs/CODin. However, the lack of feeding reduced the yield to 0.30 ± 0.02 COD-VFAs/CODin. Microbial analysis revealed that the starvation period favored the syntrophic acetate-oxidizing bacteria coupled with hydrogenotrophic methanogens. Finally, the system was fed at 9 g COD/Ld resulting in process recovery (0.39 ± 0.04 COD-VFAs/CODin). The different microbiome obtained at the end of the process was proved to be functionally redundant, highlighting the AD robustness for VFAs production.
Identification of Similar Chinese Congou Black Teas Using an Electronic Tongue Combined with Pattern Recognition
Authors: Huang Danyi , Bian Zhuang , Qiu Qinli , Wang Yinmao , Fan Dongmei , Wang Xiaochang
Published: December 2019

It is very difficult for humans to distinguish between two kinds of black tea obtained with similar processing technology. In this paper, an electronic tongue was used to discriminate samples of seven different grades of two types of Chinese Congou black tea. The type of black tea was identified by principal component analysis and discriminant analysis. The latter showed better results. The samples of the two types of black tea distributed on the two sides of the region graph were obtained from discriminant analysis, according to tea type. For grade discrimination, we determined grade prediction models for each tea type by partial least-squares analysis; the coefficients of determination of the prediction models were both above 0.95. Discriminant analysis separated each sample in region graph depending on its grade and displayed a classification accuracy of 98.20% by cross-validation. The back-propagation neural network showed that the grade prediction accuracy for all samples was 95.00%. Discriminant analysis could successfully distinguish tea types and grades. As a complement, the models of the biochemical components of tea and electronic tongue by support vector machine showed good prediction results. Therefore, the electronic tongue is a useful tool for Congou black tea classification.
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3
Authors: Dahlqvist Alexander , Mandal Santanu , Peterson Kristoffer , Håkansson Maria , Logan Derek T. , Zetterberg Fredrik R. , Leffler Hakon , Nilsson Ulf J.
Published: December 2019

The galectins are a family of galactose-binding proteins playing key roles in inflammatory processes and cancer. However, they are structurally very closely related, and discovery of highly selective inhibitors is challenging. In this work, we report the design of novel inhibitors binding to a subsite unique to galectin-3, which confers both high selectivity and affinity towards galectin-3. Olefin cross metathesis between allyl β-C-galactopyranosyl and 1-vinylnaphthalenes or acylation of aminomethyl β-C-galactopyranosyl with 1-naphthoic acid derivatives gave C-galactopyranosyls carrying 1-naphthamide structural elements that interacted favorably with a galectin-3 unique subsite according to molecular modeling and X-ray structural analysis of two inhibitor-galectin-3 complexes. Affinities were down to sub-µM and selectivities over galectin-1, 2, 4 N-terminal domain, 4 C-terminal domain, 7, 8 N-terminal domain, 9 N-terminal domain, and 9 C-terminal domain were high. These results show that high affinity and selectivity for a single galectin can be achieved by targeting unique subsites, which holds promise for further development of small and selective galectin inhibitors.
Antioxidant Activity Improvement of Apples Juice Supplemented with Chitosan-Galactose Maillard Reaction Products
Authors: Hafsa Jawhar , Smach Mohamed ali , Sobeh Mansour , Majdoub Hatem , Yasri Aziz
Published: December 2019

Chitosan-galactose Maillard reaction (CG) were prepared by heating at 100 °C for 3 hrs in a model system containing chitosan (CH) and 1%, 1.5% and 2% (w/v) of galactose. The results showed that the absorbance at 294 and 420 nm, the fluorescence intensity and the color differences of CG Maillard reaction products (MRPs) increased significantly with the increase of galactose concentration, which indicated the development of MRPs. In addition, FT-IR analysis showed that the degree of deacetylation of CG-MRPs was reduced with the increasing galactose ratio by the schiff base (–C=N) formation, indicating that the galactose has been attached to the amino group of chitosan. Likewise, the antioxidant activities (DPPH, chelating ability and reducing power) of CG-MRPs were investigated. Notably, the effect of galactose concentration in CG-MRPs was found to enhance the antioxidant activity, indicating that CG-2% exhibited the highest antioxidant activity in the range of 0.25–2.0 mg/mL. Furthermore, the apple juice supplemented with CG-MRPs could significantly improve the antioxidant activities, and CG-2% in apple juice showed the better antioxidant capacity at the concentration of 1.0 mg/mL. Thus, we conclude that CG-MRPs addition may greatly improve the antioxidant quality of apple juice.
Nitridation Temperature Effect on Carbon Vanadium Oxynitrides for a Symmetric Supercapacitor
Authors: Ndiaye Ndeye M. , Sylla Ndeye F. , Ngom Balla D. , Mutuma Bridget K. , Dangbegnon Julien K. , Ray Sekhar C. , Manyala Ncholu
Published: December 2019

In this work, porous carbon-vanadium oxynitride (C-V2NO) nanostructures were obtained at different nitridation temperature of 700, 800 and 900 °C using a thermal decomposition process. The X-ray diffraction (XRD) pattern of all the nanomaterials showed a C-V2NO single-phase cubic structure. The C-V2NO obtained at 700 °C had a low surface area (91.6 m2 g−1), a moderate degree of graphitization, and a broader pore size distribution. The C-V2NO obtained at 800 °C displayed an interconnected network with higher surface area (121.6 m2 g−1) and a narrower pore size distribution. In contrast, at 900 °C, the C-V2NO displayed a disintegrated network and a decrease in the surface area (113 m2 g−1). All the synthesized C-V2NO yielded mesoporous oxynitride nanostructures which were evaluated in three-electrode configuration using 6 M KOH aqueous electrolyte as a function of temperature. The C-V2NO@800 °C electrode gave the highest electrochemical performance as compared to its counterparts due to its superior properties. These results indicate that the nitridation temperature not only influences the morphology, structure and surface area of the C-V2NO but also their electrochemical performance. Additionally, a symmetric device fabricated from the C-V2NO@800 °C displayed specific energy and power of 38 W h kg−1 and 764 W kg−1, respectively, at 1 A g−1 in a wide operating voltage of 1.8 V. In terms of stability, it achieved 84.7% as capacity retention up to 10,000 cycles which was confirmed through the floating/aging measurement for up to 100 h at 10 A g−1. This symmetric capacitor is promising for practical applications due to the rapid and easy preparation of the carbon-vanadium oxynitride materials.
Klebsiella pneumoniae—A Useful Pathogenic Strain for Biotechnological Purposes: Diols Biosynthesis under Controlled and Uncontrolled pH Levels
Authors: Mitrea Laura , Vodnar Dan Cristian
Published: December 2019

Despite being a well-known human pathogen, Klebsiella pneumoniae plays a significant role in the biotechnology field, being considered as a microbial cell factory in terms of valuable chemical biosynthesis. In this work, Klebsiella pneumoniae DSMZ 2026 was investigated for its potential to biosynthesize 1,3-propanediol (PDO) and 2,3-butanediol (BDO) during batch fermentation under controlled and uncontrolled pH levels. The bacterial strain was cultivated at a bioreactor level, and it was inoculated in 2 L of specific mineral broth containing 50 g/L of glycerol as the main carbon source. The process was conducted under anaerobic conditions at 37 °C and 180 RPM (rotations per minute) for 24 h. The effect of pH oscillation on the biosynthesis of PDO and BDO was investigated. Samples were taken every 3 h and specific tests were performed: pH measurement, main substrate consumption, PDO and BDO production. The cell morphology was analyzed on both solid and liquid media. After 24 h of cultivation, the maximum concentrations of PDO and BDO were 28.63 ± 2.20 g/L and 18.10 ± 1.10 g/L when the pH value was maintained at 7. Decreased concentrations of PDO and BDO were achieved (11.08 ± 0.14 g/L and 7.35 ± 0.00 g/L, respectively) when the pH level was not maintained at constant values. Moreover, it was identified the presence of other metabolites (lactic, citric, and succinic acids) in the cultivation media at the beginning of the process, after 12 h and 24 h of cultivation.
Numerical and Experimental Investigation of External Characteristics and Pressure Fluctuation of a Submersible Tubular Pumping System
Authors: Jin Yan , He Xiaoke , Zhang Ye , Zhou Shanshan , Chen Hongcheng , Liu Chao
Published: December 2019

This paper presents an investigation of external flow characteristics and pressure fluctuation of a submersible tubular pumping system by using a combination of numerical simulation and experimental methods. The steady numerical simulation is used to predicted the hydraulic performance of the pumping system, and the unsteady calculation is adopted to simulate the pressure fluctuation in different components of a submersible tubular pumping system. A test bench for a model test and pressure pulsation measurement is built to validate the numerical simulation. The results show that the performance curves of the calculation and experiment are in agreement with each other, especially in the high efficiency area, and the deviation is minor under small discharge and large discharge conditions. The pressure pulsation distributions of different flow components, such as the impeller outlet, middle of the guide vane, and guide vane outlet and bulb unit, are basically the same as the measurement data. For the monitoring points on the impeller and the wall of the guide vane especially, the main frequency and its amplitude matching degree are higher, while the pressure pulsation values on the wall of the bulb unit are quite different. The blade passing frequency and its multiples are important parameters for analysis of pressure pulsation; the strongest pressure fluctuation intensity appears in the impeller outlet, which is mainly caused by the rotor–stator interaction. The farther the measuring point from the impeller, the less the pressure pulsation is affected by the blade frequency. The frequency amplitudes decrease from the impeller exit to the bulb unit.
Vapor Liquid Equilibrium Measurements of Two Promising Tertiary Amines for CO2 Capture
Authors: Pinto Diego D. D. , Zahraee Znar , Buvik Vanja , Hartono Ardi , Knuutila Hanna K.
Published: December 2019

Post combustion CO2 capture is still a rather energy intense, and therefore expensive, process. Much of the current research for reducing the process energy requirements is focused on the regeneration section. A good description of the vapor liquid equilibrium of the solvent is necessary for the accurate representation of the process. 3-(Diethylamino)-1,2-propanediol (DEA-12-PD) and 1-(2-hydroxyethyl)piperidine (12-HEPP) have been proposed as potential components in solvent blends for the membrane contactor. However, there are few available experimental data for these two tertiary amines making difficult to accurate simulate such process. In this work, we provide experimental data on the pure component saturation pressure (383 to 443 K) and on VLE of aqueous solutions of these amines (313 to 373 K) in order to fill part of the data gap. The data were used to estimate model parameters used to represent the data. The saturation pressure was modeled using the Antoine equation and the deviation is calculated lower than 2%. The NRTL model was used in this work to calculate the activity coefficients in the aqueous systems. The deviations in pressure for the aqueous systems were lower than 5% in both systems.
A New Mechanism for Soft Landing in Robotic Space Exploration
Authors: Seriani Stefano
Published: December 2019

Landing safely is the key to successful exploration of the solar system; the mitigation of the connected effects of collision in mechanical systems relies on the conversion of kinetic energy into heat or potential energy. An effective landing-system design should minimize the acceleration acting on the payload. In this paper, we focus on the application of a special class of nonlinear preloaded mechanisms, which take advantage of a variable radius drum (VRD) to produce a constant reactive force during deceleration. Static and dynamic models of the mechanism are presented. Numerical results show that the system allows for very efficient kinetic energy accumulation during impact, approaching the theoretical limit.
The Impact of Productivity, Investment and Real Wages on Employment Absorption Rate in South Africa
Authors: Habanabakize Thomas , Meyer Daniel Francois , Oláh Judit
Published: December 2019

Many developing countries are facing high levels of unemployment and most people who are employed are poorly remunerated due to low skills and productivity levels. Although jobs are important, a productive job is even more important, not only for employees, but also for employers. South Africa, being a developing country, is also facing the challenge of dramatically high levels of unemployment. This study’s aim was to examine both the short- and long-term impacts of real wages, labour productivity and investment spending on employment absorption rates in South Africa. To establish the existing relationship between variables, the study applied several econometric approaches, such as an autoregressive distributed lag (ARDL) model, error correction model (ECM) and a Toda–Yamamoto causality analysis on quarterly time series data from 1995Q1 to 2019Q1. The results revealed the existence of both short- and long-run relationships among the variables. While a positive relationship was found between employment absorption, investment spending and labour productivity, it was found that real wages negatively impact on long-run employment absorption rates. Additionally, the short-run analysis indicated that the lagged employment absorption rate influences the current rate of employment. Furthermore, the causality tests indicated that a bi-directional causal relationship exists between employment absorption and investment spending; and a uni-directional relationship between employment and both real wages and labour productivity. Based on the findings, the study recommends increments of investment spending and labour productivity that enables the South African economy to carry out more activities that would require more workers, thereby improving the employment absorption rate. The fact that labour productivity positively impacts the employment absorption rate infers the requirement for quality and skilled workers to be absorbed in the South African labour market. Therefore, labour skills improvements appear to be a prerequisite for productivity enhancement and job creation.
El Plan de Desarrollo para Centroamérica: metamorfosis regional o propuesta de transformación
Authors: Castillo Rolando
Published: December 2019

Este trabajo describe, analiza y critica el Plan de Desarrollo Integral: El Salvador-Honduras-GuatemalaMéxico. Diagnóstico, áreas de oportunidad y recomendaciones de la CEPAL, que se presentó en la Ciudad de
México en mayo de 2019. Este plan propone la construcción de un espacio económico-comercial-energético-logístico, basado en el desarrollo económico, que se concentra en los siguientes aspectos: fiscalidad
e inversión, bienestar social, sostenibilidad ambiental y gestión integral del ciclo migratorio con seguridad
humana. El plan que propuso el gobierno de Andrés Manuel López Obrador fue avalado por los distintos
gobiernos del llamado Triángulo Norte, en medio del cambio de gobierno en El Salvador, elecciones en
Guatemala y una inestabilidad creciente enHonduras, para tratar, por medio del desarrollo integral, el desafío de las migraciones centroamericanas a Estados Unidos y contrarrestar así la hostilidad de la política
migratoria de ese país hacia la subregión. La propuesta de construcción de un espacio económico común,
basado en inversiones para el desarrollo que permitan crear condiciones para la producción de riqueza y
su distribución por medio de la creación de empleo, la fiscalidad y los bienes comunes, necesita de una
estrategia de implementación lo suficientemente rápida, sólida, clara y concreta que produzca resultados
tangibles frente a la complejidad sociopolítica de la subregión.Todo esto debe hacerse en el marco de una
creciente inestabilidad derivada, entre otros factores, de la errática política estadounidense haciaAmérica
Latina y su hostilidad respecto de la migración. La parte final del trabajo se centra en la viabilidad política
y financiera del plan y en algunas recomendaciones para la cooperación.
NEUROMARKETING EN EL SERVICIO DE INTERNET 4G LTE EN LA CIUDAD DE SUCRE: ESTUDIO DE CASO EMPRESA VIVA
Authors: Flores Mancilla Mirko Divar
Published: December 2019

El presente artículo trata acerca del abordaje de nuevas técnicas de conocimiento de los procesos de comportamiento de los consumidores en el ámbito del Neuromarketing, en el entendido que la inteligencia artificial y las técnicas procedentes de las neurociencias, constituyen nuevas vías de acceso a los consumidores que complementan las estrategias tradicionales. Metodológicamente se aborda bajo en enfoque mixto de tipo explicativo. El objeto de estudio es la empresa VIVA en el sector de internet 4G LTE domiciliario en la ciudad de Sucre, una empresa que avanza con la tecnología. Con el estudio realizado se puede concluir que, el Neuromarketing trae consigo un conjunto de recursos de enorme valor para investigar el mercado y desarrollar estrategias exitosas en el producto, posicionamiento, precios, comunicaciones y canales de distribución.
MANUAL DE NORMAS Y PROCEDIMIENTOS CONTABLES PARA EL ÁREA DE CUENTAS POR COBRAR DE LA EMPRESA “INVERSIONES M.C.H., C.A.”
Authors: Viloria Arianny , Zapata Verusska
Published: December 2019

La investigación que da origen a este artículo surgió con el objetivo de diseñar un manual de normas y procedimientos contables en el área de cuentas por cobrar para la empresa “Inversiones M.C.H., C.A.”, considerando la problemática existente por no contar con personal encargado únicamente para el área descrita. Se realizó una investigación basada en proyecto factible, cuyo diseño es de investigación de campo de tipo descriptivo. Se aplicó la técnica de observación directa, y como mecanismo para conocer la percepción de quienes ejecutan el trabajo, se aplicó la técnica de la entrevista de tipo semi-estructurada, basada en preguntas abiertas, para lo cual se utilizó un cuaderno de notas, cámara fotográfica y grabador de audio como instrumentos de recolección de datos, aplicado a una muestra finita y pequeña de dos empleados. Se concluye que los resultados demostraron la necesidad que tiene la empresa de contar con lineamientos para el manejo eficaz del área de Cuentas por Cobrar, que permita el manejo adecuado de los procesos de cobranza.
The ancient city and the contemporary ancient city
Authors: Da Silva Francisco Gilberto , Silva Glaydson José da
Published: December 2019

The new dossier of Revista Heródoto, titled “Cities And Peripheral Areas In The Ancient Word” considers the importance of understanding in parallel the ancient city and the contemporary city we live in. The dossier's contributions point out the co-dependency of these two cities and the need to reflect on their interpreters and their complex connections with the “world around”.
Entre o antigo e o mundo moderno: guerra e comunidade na tipologia das cidades de Max Weber
Authors: Moerbeck Guilherme
Published: December 2019

Economia e Sociedade , uma das obras mais influentes do início do século XX, com reflexos em diversos ramos das Ciências Humanas, é um texto de especial interesse aos pesquisadores da História Antiga, em especial na Tipologia das Cidades . Ainda que os objetivos maiores de Max Weber ao compor o seu texto estivessem vinculados, flagrantemente, à avaliação do mundo contemporâneo, a densidade do texto weberiano, fruto de uma erudição ímpar, revelou uma análise profunda e singular sobre a pólis, a cidade grega antiga. O objetivo desse artigo é analisar, sob a luz da crítica historiográfica e de uma análise cuidadosa da Tipologia , as escolhas interpretativas de Weber, em especial, no que se refere aos tipos ide

ais que construiu para compreender a cidade dos gregos antigos.
As Origens Da Rota Marítima: Mares, Barcos E Homens
Authors: Arnauld Pascal , Alberto Dantas Felipe
Published: December 2019

Este texto é a tradução do capítulo “Aux origines de lar oute maritime: des mers, des bateaux et des hommes”, publicado no livro “Les routes de la navigation antique: itineraires en Méditerranée”, de autoria de Pascal Arnaud. Como um todo a obra concebe o Mediterrâneo como um espaço de união entre os povos antigos, como espaço de diferentes circulações entre mercadorias, pessoas, ideias, modelos econômico-sociais e políticos.Especificamente o capítulo trata de rotas e fluxos, condições naturais, ventos, correntes, sazonalidades e limites e possibilidades da navegação antiga, em geral.
Étude historique de l’evolution de la maxime hippocratique en grec dans le Traite D’hippocrate Épidemies I. 5 A laa maxime latine dans la tradition latine attestee par Lactance dans son Epitome des institutions divines, Chapitre 60
Authors: Dias Mayoro
Published: December 2019

Les sociétés africaines ont eu des organisations qui ont évolué et se sont maintenues en dépit du temps qui nous sépare de l’Antiquité. Parmi celles-ci, nous avons les castes qui sont, pour certains, une absurdité qu’ilfaut abandonner sans chercher à les comprendre. Pourtant, celles-ci peuvent nous éclairer sur le fonctionnement de notre société et son évolution. Les castes sont une stratification sociale établie sur la base des activités professionnelles, des métiers. C’est en Egypte ancienne qu’elles vont se professionnaliser et s’hériter. Au fil du temps, la religion et la loi vont intervenir dans le système des castes pour y introduire l’endogamie, la hiérarchie et le mépris tels que nous l’observons, aujourd’hui, chez certaines ethnies africaines.
RUBIERA CANCELAS, CARLA. LA ESCLAVITUD FEMENINA EN LA ROMA ANTIGUA. FAMULAE, ANCILLAE ET SERUAE (COLECCIÓN DEMÉTER). OVIEDO: EDICIONES TRABE, 2014. 302 p. ISBN: 978-84-8053-777-3
Authors: N. Silva Filipe
Published: December 2019

Resenha de: RUBIERA CANCELAS, CARLA. LA ESCLAVITUD FEMENINA EN LA ROMA ANTIGUA. FAMULAE, ANCILLAE ET SERUAE

(COLECCIÓN DEMÉTER). OVIEDO: EDICIONES TRABE, 2014. 302 p. ISBN: 978-84-8053-777-3
FLOWER, HARRIET. THE DANCING LARES AND THE SERPENT IN THE GARDEN: RELIGION AT THE ROMAN STREET CORNER. PRINCETON: PRINCETON UNIVERSITY PRESS, 2017. 416 P. ISBN: 0691175004
Authors: Da Cruz Moreira Jonathan
Published: December 2019

Resenha
Fantastic technology in early Irish literature
Authors: Sayers William
Published: December 2019

La technologie fabuleuse dans la littérature irlandaise ancienne

La description d’objets techniquement ingénieux ou complexes n’est pas un thème reconnu de la littérature irlandaise ancienne, mais l’on trouve des exemples de moyens de transport, de pièces d’armement et de procédés pour acquérir ou préparer des aliments qui montrent qu’une intrigue peut impliquer un élément de technologie fabuleuse – ce dernier pouvant apparaître comme un thème quasiment indépendant dans une histoire culturelle foisonnante. Les objets merveilleux ne sont pas surnaturels, ni même magiques ; pourtant, il s’agit d’objets fantastiques qui ont dû avoir plus d’existence dans la littérature qu’ils n’en ont jamais eu dans la réalité historique. La «réalisation» verbale de ces procédés suppose une domestication et une exploitation du langage, dont la complexité potentielle reflète bien celle de ces inventions.
Kuitoi Lekatos. Une nouvelle lecture de la pierre de San Bernardino di Briona (Novara)
Authors: Estarán Tolosa María José
Published: December 2019

L’inscription gauloise de San Bernardino di Briona (Novare) est souvent citée pour illustrer les premiers stades de la romanisation de la Gaule cisalpine. Les épigraphistes ont eu tendance à considérer que cette inscription contenait une liste de noms propres, parmi lesquels se trouvait un praenomen romain appartenant à un legatus local, ce qui est un phénomène extrêmement rare. L’idée a été développée que ce kuitos lekatos aurait reçu ce titre honorifique pour services rendus à Rome. Cet article réévalue la notion de legatus dans le contexte historique de l’inscription et propose une nouvelle lecture du texte, fondée sur une autopsie. D’une part, la lecture traditionnelle en est considérablement transformée ; d’autre part, il apparaît qu’il n’y a pas de lien syntaxique entre le nom propre et le titre présumé.
Papel del Profesor en la Orientación y Conformación del Proyecto de vida de los Estudiantes
Authors: Carbonell Lahera Neosotis , Tissert Debrosse Yaritza , Pérez Obregón Dariela
Published: December 2019

El artículo aborda consideraciones sobre la conformación del proyecto de vida para nuestros estudiantes en las universidades y el papel del profesor en la orientación educativa y psicopedagógica para tales fines. Concebido como acto personal intransferible que compromete nuestro ser y hacer para lograr darnos una oportunidad de expresarnos socialmente como personas constructivas, participativas y vinculadas con lo mejor de los ideales sociales y humanos que nos congregan durante la etapa socio-histórica que nos toca vivir. Se analizan las bases para su construcción así como los elementos que se deben considerar. Se sugieren algunas pautas a las que el profesor puede acceder a una guía mucho más eficiente de proyectar la vida hacia el futuro desde el presente. Es intención socializar algunos elementos teóricos en los que se profundizan desde la orientación educativa y psicopedagógica de la conformación del proyecto de vida en el proceso de formación de estudiantes de las carreras pedagógicas y que posibilitan, a través de la propuesta de pautas para su implementación, la comprensión de los mismos para su aplicación práctica por los profesores de la universidad.
Epistemología de la Orientación Preventiva. Una Función del Maestro
Authors: Rodriguez Caballero Giselle Aurelia , Caballero Rodriguez Ana Norvis , Naranjo Vaca Gregory Edison
Published: December 2019

El trabajo que se presenta, parte de reconocer los fundamentos que sustentan los procesos de formación, orientación y la prevención, cómo han sido abordadas desde diferentes posturas y posiciones teóricas. Su objetivo se orienta al perfeccionamiento del proceso de formación inicial del estudiante de Licenciatura en Educación. Primaria y la necesidad de su preparación como agente social de la cultura y de la educación de las nuevas generaciones. Para el desarrollo de la temática se emplearon métodos como análisis síntesis, histórico lógico, sistémico estructural, observación, entrevista, revisión de documentos. Se incluyen los modos de actuación profesional orientador preventivo para la función orientadora preventiva en los estudiantes de la Licenciatura de Educación. Primaria.
La Formación Permanente de los Docentes Universitarios para el Logro de una Cultura Profesional Pedagógica
Authors: Cuadréns Villalón Alina María , Montoya Rivera Jorge , Montoya Hernández Teresa
Published: December 2019

En este trabajo se indaga e interpreta el proceso de formación profesional permanente de los docentes universitarios, el cual sugiere una valoración epistémica y praxiológica que propicie el reconocimiento y validez en la transformación universitaria. Las propuestas y estrategias de formación de los docentes universitarios desde la perspectiva de una formación a la cual los teóricos han llamado permanente no se garantiza sólo a través de su formación inicial, sino que debe continuar desde su propia actividad profesional en el contexto educativo, y estar en correspondencia con las necesidades de la sociedad en que se desenvuelve. Este proceso de formación profesional permanente de los docentes universitarios contribuye a eliminar las barreras epistemológicas y praxiológicas del proceso de formación permanente y contribuye al logro de una cultura profesional pedagógica.
Reflexiones en Torno a la Superación del Docente Angolano para favorecer el Enriquecimiento Intelectual del Escolar
Authors: Soares Da Costa Marilia Augusta
Published: December 2019

La superación profesional de los docentes en la República de Angola es hoy un reto para perfeccionar el proceso de enseñanza aprendizaje en los diferentes niveles educativos, en particular en cómo favorecer el enriquecimiento intelectual de los alumnos, lo que supone la mejor asimilación de contenidos, la adquisición de habilidades, capacidades y el desarrollo de la inteligencia. En este empeño cada docente desempeña un papel primordial para lograrlo, en coordinación con otras agencias e influencias educativas. En las investigaciones actuales sea punta que todo escolar puede alcanzar un desarrollo intelectual y tiene potencialidades para desarrollar varios tipos de inteligencia, el alcance de esta propuesta requiere de la preparación del docente para estimular las diferentes formas, estilos y estrategias de aprender, recordar, actuar, y comprender. Es objetivo de ofrecer reflexiones teóricas que sienten pautas al docente, durante el proceso de enseñanza aprendizaje, para el enriquecimiento intelectual de los escolares angolanos. Para lo cual se emplearon métodos de corte teórico como el análisis y la síntesis, inducción- deducción y la hermenéutica.
Tutorial Interactivo para la Enseñanza de la Programación Orientada a Objetos
Authors: Almarales Marina , García Fernández Oscar
Published: December 2019

Las dificultades en el aprendizaje de la Programación Orientada a Objetos se hacen evidentes en los estudiantes que cursan la carrera de Ingeniería en Telecomunicaciones y Electrónica en la Universidad de Oriente. Conceptos como la abstracción, herencia, polimorfismo, característicos de este paradigma, se tornan difíciles de asimilar para los estudiantes que cursan las asignaturas Programación I y II. Con el objetivo de darle solución a este problema y teniendo en cuenta la necesidad de motivar a los estudiantes por el estudio de la programación, se desarrolló una herramienta de tipo tutorial basada en las Tecnologías de la Información y las Comunicaciones. La misma tiene como objetivo facilitar y apoyar el proceso de enseñanza-aprendizaje del paradigma orientado a objetos empleando el lenguaje C++. En el presente artículo se exponen las características de este tutorial y sus ventajas desde el punto de vista didáctico, las cuales se comprobaron luego de su aplicación.
A study of the effect of Paclitaxel, Docetaxel and Tamoxifen citrate coumpounds found in Taxus wallichiana on the Beta-tubulin and Estrogen Receptor (ESR) proteins in humans using a bioinformatics approach
Authors: Thakuria Bikash , Purkayastha Devatrisha , Adhikari Samrat
Published: December 2019

Taxus wallichiana, an indigenous plant of North East India contains bioactive compounds such as Tamoxifen citrate and taxol (paclitaxel and docetaxel) which inhibit the growth of cancerous cells. Tamoxifen citrate in its active form competitively inhibits the binding of estradiol or estrogen with estrogen receptor and results in tumor suppression whereas the taxol compounds stabilize the tubulin protein in microtubules and inhibit cell division in cancerous cells. In this approach, important domains and motifs of the protein receptors were studied and analyzed followed by homology modeling and its validation. Molecular docking studies were carried out via tubulin and estrogen receptor with paclitaxel, docetaxel, and endoxifen (an active form of tamoxifen citrate). Hence it was verified that tubulin and estrogen receptor contain binding sites for the bioactive compounds found in T. wallichiana and these bioactive compounds after binding with these receptors result in the prevention of the proliferation of the tumorous cells by stabilizing the microtubules and preventing the intake of steroidal hormones by cells respectively.
Isolation and identification of the same type LMG1242 of biosurfactant-producing strain of Pseudomonas aeruginosa from different oil contaminated soils
Authors: Ghavipanjeh Farideh , Moradi Ghasem
Published: December 2019

Emulsification is a major rate limiting step in any biological conversion of heavy hydrocarbons. Here, thirty bacterial strains were isolated from seven native consortia and screened for biosurfactant-producing activities which could enhance emulsification of heavy oils. The consortia were obtained by sampling from oil contaminated soils of different petroleum refineries of Iran. The oil spreading test, drop collapse test, emulsification index (E24) and surface tension measurements were used to evaluate the biosurfactant producing activities of the strains. A total number of 5 strains out of 30 were finally selected as the best biosurfactant-producing bacteria. The clear zone diameters in their oil spreading test were 4 to 5 cm, and E24 were 48 to 92%. The selected strains also properly lowered the surface tensions of the supernatants to 23.5-32 mN/m when grown on heavy diesel. All the selected strains were identified by 16S rRNA sequencing analysis as Pseudomonas aeruginosa LMG1242 (99.9% homology) which is a newly isolated type in oil polluted soils. The results suggest P. aeruginosa LMG1242 as a predominant and highly active biosurfactant producing bacterium which could be further evaluated in petroleum bioremediation and bioprocessing applications.
A SIMPLIFIED ANALYTICAL PROCEDURE FOR SEISMIC ANALYSIS OF TIMBER LIGHT-FRAME SHEAR WALLS
Authors: Di Gangi Giorgia , Monti Giorgio , Quaranta Giuseppe , Vailati Marco , Demartino Cristoforo
Published: December 2019

The seismic performance of timber light-frame shear walls is investigated in this paper with a focus on energy dissipation and ductility ensured by sheathing-to-framing connections. An original parametric finite element model has been developed in order to perform sensitivity analyses. The model considers the design variables affecting the racking load-carrying capacity of the wall. These variables include aspect ratio (height-to-width ratio), fastener spacing, number of vertical studs and framing elements cross-section size. A failure criterion has been defined based on the observation of both the global behaviour of the wall and local behaviour of fasteners in order to identify the ultimate displacement of the wall. The equivalent viscous damping has been numerically assessed by estimating the damping factor which is in use in the capacity spectrum method. Finally, an in-depth analysis of the results obtained from the sensitivity analyses led to the development of a simplified analytical procedure which is able to predict the capacity curve of a timber light-frame shear wall.
Efek Pemberian Eugenol Isolat Bunga Cengkeh (Syzygium aromaticum) terhadap Histologi Pankreas Tikus Diabetes
Authors: Utami Sinta Wahyu , Sudarma I Made , Hamdin Candra Dwipayana
Published: December 2019

Diabetes melitus merupakan penyakit yang prevalensinya tinggi di Indonesia, dari tahun ketahun prevalensinya terus meningkat. Sehingga sebagian peneliti mulai melakukan eksplorasi bahan alam dalam pencegahan maupun penanganan diabetes melitus. Bunga Cengkeh (Syzygium aromaticum) mengandung senyawa eugenol yang secara ilmiah dapat menurunkan kadar gula darah. Penelitian ini bertujuan untuk mengetahui efek pemberian eugenol isolat bunga cengkeh terhadap histologi pankreas tikus diabetes. Bunga cengkeh diektraksi menggunakan metode maserasi menggunakan pelarut n-heksan, kemudian eugenol disolasi menggunakan metode asam-basa kemudian diuji dengan KLT. Pengaruh pemberian eugenol dilihat dengan menginduksi aloksan dengan dosis 125 mg/kgBB secara intraperitoneal kemudian emulsi eugenol dosis 10 mg/ KgBB dibandingkan dengan glibenklamid 1,35 mg/KgBB secara oral selama 14 hari kemudian dilakukan histologi pankreas. Pengamatan hasil histologi pankreas dilakukan dengan membuat preparat pankreas menggunakan pengecatan Hematoxilin Eosin (HE). Hasil penelitian menunjukan tikus yang diinduksi aloksan mengalami kerusakan sel pankreas. Namun, setelah diberikan perlakukan glibenklamid dan senyawa eugenol mampu  memperbaiki sel pankreas yang mengalami kerusakan akibat pemberian aloksan.
Uji In Vitro dan Studi In Silico Senyawa Turunan n’-benzoylisonicotinohydr
Authors: Ruswanto Ruswanto , Rahayuningsih Nur , Hidayati Nur Laeli Dwi , Nuryani Ginna Sri , Mardianingrum Richa
Published: December 2019

Telah dilakukannya penelitian tentang studi in vitro dan in silico senyawa turunan N-Benzoylisonicotinohydrazide. Penelitian ini bertujuan untuk mengetahui bahwa senyawa turunan N’-benzoylisonicotinohydrazide dapat menghambat aktivitas bakteri gram positif, gram negatif dan Mycobacterium tuberculosis, serta mempunyai interaksi yang baik dengan Enoyl-Acyl Carrier Protein Reductase dari Mycobacterium Tuberculosis. Dari uji in vitro dihasilkan bahwa senyawa N’-benzoylisonicotinohydrazide memiliki Minimum Inhibitor Concentration (MIC) sebesar 0,33 µg/ml terhadap bakteri Basillus subtilis, sedangkan besarnya Minimum Inhibitor Concentration (MIC) senyawa N’-(2-chlorobenzoyl)isonicotinohydrazide terhadap Mycobacterium tuberkulosis (H37Rv) adalah sebesar 3,125 µg/ml. Dari studi in silico didapat bahwa nilai binding affinity antara senyawa N’-(2-chlorobenzoyl)isonicotinohydrazide enzim Enoyl-Acyl Carrier Protein Reductase (2X23) mempunyai binding affinity yang paling kecil sehingga dapat diprediksi bahwa senyawa tersebut mempunyai interaksi yang stabil dan paling baik disbanding senyawa-senyawa lainnya sehingga senyawa N’-(2-chlorobenzoyl)isonicotinohydrazide dapat digunakan sebagai kandidat antituberkulosis yang lebih poten.
In-Vitro Characterization of Nanoparticles and Antiagregation Tests on Brown Seaweed Extracts (Sargassum polycystum) Types of Sellulase Enzyme Hydrolysis
Authors: Kartiningsih Kartiningsih , Abdillah Syamsudin , Simanjuntak Partomuan , Cyntia Cyntia , Haryo Haryo
Published: December 2019

Brown seaweed contains fucoidan, a large molecular weight sulfate polysaccharide (about 100,000 Da) which has platelet antiagregation activity. This activity is achieved if the fucoidan has a small molecular weight (3900-7600 Da) so this activity can increase by hydrolized with sellulase Enzym. The purpose of this study was to obtain extract nanoparticles that meet physical quality requirements and have a higher platelet antiagregation activity than brown seaweed extract both before and after hydrolysis. Extraction was using kinetic maseration method using 80% ethanol after that using 2% calcium chloride solution. The results were dried and hydrolyzed with cellulase enzyme and nanoparticles were made by ionic gelation method. Nanoparticle characterization results in particle size of 552.8, polydispersity index of 0.569, potential zeta of +53.5 mV, and spherical shape. In-vitro testing results for platelet antiagregation activity showed the percentage of platelet aggregation inhibition of brown seaweed extract with a concentration 500µg / mL is 22.19% and extracts after hydrolysis was 57.94% and nanoparticles extract after hydrolysis was 72.93%. Extract nanoparticles meet physical quality requirements and extracted nanoparticles after hydrolysis have the highest platelet antiagregation activity compared to brown seaweed extract both before and after hydrolysis.
Antibacterial Activity of Allium ascalonicum Linn Fractions A562275sal from the Palu Valley against Shigella dysenteriae
Authors: Khumaidi Akhmad , Maulina Kumalahayati , Nugrahani Arsa Wahyu
Published: December 2019

Shallot (Allium ascalonicum Linn.) is one of the typical plants of Central Sulawesi which is used as traditional medicine such as to treat infectious diseases. This study aims to determine the fractions that have high activity from bulbs and leaves in inhibiting the growth of Shigella dysenteriae bacteria and determining the organic compounds that have antibacterial activities. Extraction was carried out by maceration method using ethanol 96% for both samples. Liquid-liquid fractionation was used as a fractionation method using hexane, ethyl acetate and water  solvents, sequenly. The antibacterial activity test used the diffusion method with the pile technique and TLC-bioautography. The results showed that ethyl acetate fraction gave the highest activity of bulbs samples, while in leaves samples ethyl acetate fraction and hexane fraction were able to provide good inhibitory activity. The organic compounds were identified by thin layer chromatography method. Flavonoids compounds have identified for bulbs samples (Rf 0.18). In the leaves samples, steroids compounds were identified in the ethyl acetate fraction (Rf 0.62) and terpenoid compounds (Rf 0.48) in the hexane fraction. Based on the result, the shallot is potentially be developed as an antibacterial material.
Efek Antidiare Infusa Daun Senggani (Melastoma malabathricum L.) Pada Mencit Jantan Galur Swiss Webster Yang Di Induksi Oleum ricini
Authors: Suliska Nova , E Thito Dwi , Herlinda Herlinda
Published: December 2019

Diare merupakan gangguan buang air besar (BAB) yang ditandai dengan BAB lebih dari 3 kali sehari dengan konsistensi tinja cair, dapat disertai dengan darah dan atau lendir. Salah satu tanaman yang berkhasiat dan digunakan masyarakat sebagai antidiare adalah senggani (Melastoma malabathricum L.). Penelitian ini bertujuan untuk mengetahui efek dan dosis efektif infusa daun senggani terhadap mencit yang diinduksi diare dengan Oleum ricini. Mencit dikelompokkan menjadi 5 kelompok: kelompok kontrol positif (induksi diare), kelompok pembanding (loperamid), dan kelompok uji infusa daun senggani dosis 26 mg/kg BB, 52 mg/kg BB, dan 104 mg/kg BB. Mencit diinduksi diare dengan Oleum ricini, 30 menit kemudian mencit diberikan sediaan uji kecuali kelompok kontrol positif. Frekuensi, bobot, dan konsistensi feses diukur setiap 30 menit selama 4 jam. Hasil penelitian menunjukkan kelompok infusa daun senggani dosis 52 mg/kg BB menunjukkan frekuensi dan bobot feses yang lebih rendah berbeda bermakna dibandingkan dengan kelompok kontrol positif (P<0,5) pada pengamatan menit ke-240. Konsistensi feses kelompok infusa daun senggani dosis 52 mg/kg BB cenderung normal pada pengamatan menit ke-240.  Infusa daun senggani dosis 52 mg/kg BB menunjukkan efek antidiare yang paling baik dibandingkan dengan infusa daun senggani dosis 26 mg/kg BB dan 104 mg/kg BB pada mencit yang diinduksi Oleum ricini.
Ovarian Cancer Animal Models for Preclinical Studies and Development of Ovarian Cancer Drugs
Authors: Dwi Sandhiutami Ni Made , Wuyung Puspita Eka , Arozal Wawaimuli , Louisa Melva , Rahmat Deni
Published: December 2019

Treatment for ovarian carcinoma is still far from optimal, animal models are still needed to study human epithelial ovarian cancer. Animal models of ovarian cancer are very important for understanding the pathogenesis of the disease and for testing new treatment strategies. Ovarian carcinogenesis models in mice have been modified and repaired to produce preneoplastic lesions and neoplastic ovaries that are pathogens resembling human ovarian cancer. Although spontaneous ovarian tumors in mice have been reported, some of the shortcomings of existing studies preclude their use as animal models of ovarian cancer. Because of this, many efforts have been made to develop animal models that are relevant for ovarian cancer. Experimental animal models are developed accurately to represent cellular and molecular changes associated with the initiation and development of human ovarian cancer. Accurate experimental models have significant potential in facilitating the development of better methods for early detection and treatment of ovarian cancer. Several animal models of ovarian cancer have been reported, including manipulation of various reproductive factors or exposure to carcinogens. The latest advance in ovarian cancer modeling is using genetically engineered mice.