bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term osteogenic differentiation of human bone marrow stromal cells in simulated microgravity: novel proteins sighted
Authors: Montagna Giulia , Pani Giuseppe , Flinkman Dani , Cristofaro Francesco , Pascucci Barbara , Massimino Luca , Lamparelli Luigi Antonio , Fassina Lorenzo , James Peter , Coffey Eleanor , Rea Giuseppina , Visai Livia , Rizzo Angela Maria
Published: October 2022

Microgravity-induced bone loss is a major concern for space travelers. Ground-based microgravity simulators are crucial to study the effect of microgravity exposure on biological systems and to address the limitations posed by restricted access to real space. In this work, for the first time, we adopt a multidisciplinary approach to characterize the morphological, biochemical, and molecular changes underlying the response of human bone marrow stromal cells to long-term simulated microgravity exposure during osteogenic differentiation. Our results show that osteogenic differentiation is reduced while energy metabolism is promoted. We found novel proteins were dysregulated under simulated microgravity, including CSC1-like protein, involved in the mechanotransduction of pressure signals, and PTPN11, SLC44A1 and MME which are involved in osteoblast differentiation pathways and which may become the focus of future translational projects. The investigation of cell proteome highlighted how simulated microgravity affects a relatively low number of proteins compared to time and/or osteogenic factors and has allowed us to reconstruct a hypothetical pipeline for cell response to simulated microgravity. Further investigation focused on the application of nanomaterials may help to increase understanding of how to treat or minimize the effects of microgravity.
Choosing the right tool: Leveraging of plant genetic resources in wheat (Triticum aestivum L.) benefits from selection of a suitable genomic prediction model
Authors: Berkner Marcel O. , Schulthess Albert W. , Zhao Yusheng , Jiang Yong , Oppermann Markus , Reif Jochen C.
Published: October 2022

Key message

Genomic prediction of genebank accessions benefits from the consideration of additive-by-additive epistasis and subpopulation-specific marker effects.

Wheat (Triticum aestivum L.) and other species of the Triticum genus are well represented in genebank collections worldwide. The substantial genetic diversity harbored by more than 850,000 accessions can be explored for their potential use in modern plant breeding. Characterization of these large number of accessions is constrained by the required resources, and this fact limits their use so far. This limitation might be overcome by engaging genomic prediction. The present study compared ten different genomic prediction approaches to the prediction of four traits, namely flowering time, plant height, thousand grain weight, and yellow rust resistance, in a diverse set of 7745 accession samples from Germany’s Federal ex situ genebank at the Leibniz Institute of Plant Genetics and Crop Plant Research in Gatersleben. Approaches were evaluated based on prediction ability and robustness to the confounding influence of strong population structure. The authors propose the wide application of extended genomic best linear unbiased prediction due to the observed benefit of incorporating additive-by-additive epistasis. General and subpopulation-specific additive ridge regression best linear unbiased prediction, which accounts for subpopulation-specific marker-effects, was shown to be a good option if contrasting clusters are encountered in the analyzed collection. The presented findings reaffirm that the trait’s genetic architecture as well as the composition and relatedness of the training set and test set are major driving factors for the accuracy of genomic prediction.
Comparing Effects of Bariatric Surgery on Body Composition Changes in Metabolically Healthy and Metabolically Unhealthy Severely Obese Patients: Tehran Obesity Treatment Study (TOTS)
Authors: Heidari Almasi Minoo , Barzin Maryam , Mahdavi Maryam , Khalaj Alireza , Ebrahimi Danial , Valizadeh Majid , Hosseinpanah Farhad
Published: October 2022

Background

Among two popular obesity phenotypes, metabolically healthy severely obese (MHSO) and metabolically unhealthy severely obese (MUSO), it is important to clarify whether or not those with MHSO phenotype would benefit from bariatric surgery in terms of an improvement in body composition parameters.

Methods

A prospective cohort was conducted on a total of 4028 participants (1404 MHSO and 2624 MUSO) who underwent bariatric surgery; MHSO was defined as having abnormalities in none or one of these four parameters: systolic blood pressure and/or diastolic blood pressure, triglycerides, fasting plasma glucose, and high‐density lipoprotein. Otherwise, the definition of MUSO was met. Body composition analysis was performed at the baseline and 6‐, 12‐, 24‐, and 36‐month post‐surgery using bioelectrical impedance analyzer.

Results

Both phenotypes showed a significant decrease in fat mass (FM) and fat‐free mass (FFM) and a significant increase in EWL% and TWL% (Ptrend < 0.05). FFM, FM%, and excess weight loss (EWL%) were significantly different between the two phenotypes (Pbetween < 0.05) during the follow‐up. Multivariate linear regression demonstrated that compared to MUSO patients, MHSO individuals experienced a greater increase in total weight loss (TWL%) and EWL% at 12‐ and 24‐month and in EWL% at 36‐month post‐surgery and also a lower decrease in the FFML/WL% after 12 months.

Conclusion

Despite a lower decrease of FFML/WL% and a greater increase in TWL and EWL in MHSO phenotype at some time points, there were no clinically significant differences between the study groups in terms of body composition changes throughout the follow‐up period.
TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review
Authors: Zhang Heyang , Zhan Qianru , Wang Xiaoxue , Gao Feng , Yu Jinxiang , Wang Jing , Fu Wei , Wang Pingping , Wei Xin , Zhang Lijun
Published: October 2022

To investigate the pathogenesis and the refractory/relapse mechanisms in patients with t(16;21)(p11;q22), we retrospectively analyzed the clinical data of six cases in our hospital and sixty-two cases reported in the literature. Among the patients in our hospital, five cases were diagnosed as acute leukemia, and one was myelodysplastic syndrome evolved to acute myeloid leukemia, harboring TLS/FUS-ERG fusion gene; all the cases were detected t(16;21)(p11;q22) translocation, and five cases showed additional chromosomal abnormalities. We firstly report a novel three-way translocation t(11;16;21)(q13;p11;q22), which may affect the prognosis of leukemia with TLS-ERG fusion gene because this patient shows a more satisfactory treatment effect and deeper remission. And we found patients with TLS-ERG are more likely to have bone and arthrosis pain. Besides, CD56 and CD123 were positive in these cases, which are related to poor prognosis and the character of refractory. Moreover, some gene mutations are involved, and GATA2 and SMAD4 mutations were identified when the disease progressed from myelodysplastic syndrome to leukemia. Among sixty-two patients reported in the literature, valid positive percent of CD56 and CD123 were 81% and 14.3%, respectively. Mutation of the RUNX1 gene was detected in four cases, and one patient had multiple mutations, including BCOR, PLCG1, DIS3, BRAF, JAK2, and JAK3. The prominent feature of leukemia carrying the TLS/FUS-ERG gene is its poor prognosis. The relevant mechanism includes new mutation, jumping translocation, different transcripts, and so on. The mechanism still acquaints scarcely, which requires further study.
Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas
Authors: Goschzik Tobias , Mynarek Martin , Doerner Evelyn , Schenk Alina , Spier Isabel , Warmuth-Metz Monika , Bison Brigitte , Obrecht Denise , Struve Nina , Kortmann Rolf-Dieter , Schmid Matthias , Aretz Stefan , Rutkowski Stefan , Pietsch Torsten
Published: October 2022

This study aimed to re-evaluate the prognostic impact of TP53 mutations and to identify specific chromosomal aberrations as possible prognostic markers in WNT-activated medulloblastoma (WNT-MB). In a cohort of 191 patients with WNT-MBs, mutations in CTNNB1, APC, and TP53 were analyzed by DNA sequencing. Chromosomal copy-number aberrations were assessed by molecular inversion probe technology (MIP), SNP6, or 850k methylation array hybridization. Prognostic impact was evaluated in 120 patients with follow-up data from the HIT2000 medulloblastoma trial or HIT registries. CTNNB1 mutations were present in 92.2%, and APC mutations in 6.8% of samples. One CTNNB1 wild-type tumor gained WNT activation due to homozygous FBXW7 deletion. Monosomy 6 was present in 78.6%, and more frequent in children than adults. 16.1% of tumor samples showed TP53 mutations, of those 60% with nuclear positivity for the p53 protein. Loss of heterozygosity at the TP53 locus (chromosome 17p13.1) was found in 40.7% (11/27) of TP53 mutant tumor samples and in 12.6% of TP53 wild-type cases (13/103). Patients with tumors harboring TP53 mutations showed significant worse progression-free survival (PFS; 5-year-PFS 68% versus 93%, p = 0.001), and were enriched for chromosomes 17p (p = 0.001), 10, and 13 losses. Gains of OTX2 (14q22.3) occurred in 38.9% of samples and were associated with poor PFS and OS (5-year-PFS 72% versus 93%, p = 0.017 resp. 5-year-OS 83% versus 97%, p = 0.006). Multivariable Cox regression analysis for PFS/OS identified both genetic alterations as independent prognostic markers. Our data suggest that patients with WNT-MB carrying TP53 mutations or OTX2 gains (58.1%) are at higher risk of relapse. Eligibility of these patients for therapy de-escalation trials needs to be debated.
A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy
Authors: Grasl Stefan , Frommlet Florian , Faisal Muhammad , Marijic Blazen , Schmid Elisabeth , Heiduschka Gregor , Brunner Markus , Grasl Matthaeus C. , Erovic Boban M. , Janik Stefan
Published: October 2022

Background

To create nomograms for better prediction of the oncological outcome in advanced laryngeal (LxCAs) or hypopharyngeal (HpxCAs) cancer after laryngopharyngectomy.

Materials

239 patients who underwent total laryngectomy or laryngopharyngectomy due to LxCA (52.7%) or HpxCA (47.3%) were included in this study. Based on clinical risk factors (tumor site, lymph node involvement, salvage setting), we created nomograms for prediction of disease-specific survival (DSS) and disease-free survival (DFS).

Results

HpxCAs showed a higher rate of lymph node involvement (p < 0.001), a 2.47-fold higher risk of a 2nd head and neck cancer (p = 0.009) and significantly worse loco-regional control rates (p = 0.003) compared to LxCAs. Positive neck nodes and salvage procedures were associated with significantly worse outcome. Nomograms demonstrated that hypopharyngeal tumors with positive neck nodes in salvage situations had the worst oncological outcome with a 5-year DSS of 15–20%.

Conclusions

The oncological outcome is worse in hypopharyngeal carcinomas and could be easily quantified by our nomograms that are based on tumor site, lymph node involvement and salvage situation.
MRI correlates of motoneuron loss in SMA
Authors: Sprenger-Svačina Alina , Haensch Johannes , Weiss Kilian , Große Hokamp Nils , Maintz David , Schlamann Marc , Fink Gereon R. , Schloss Natalie , Laukamp Kai , Wunderlich Gilbert , Lehmann Helmar C. , Lichtenstein Thorsten
Published: October 2022

Background

Magnetic resonance imaging (MRI) is currently explored as supplemental tool to monitor disease progression and treatment response in various neuromuscular disorders. We here assessed the utility of a multi-parametric magnetic resonance imaging (MRI) protocol including quantitative water T2 mapping, Dixon-based proton density fat fraction (PDFF) estimation and diffusion tensor imaging (DTI) to detect loss of spinal motor neurons and subsequent muscle damage in adult SMA patients.

Methods

Sixteen SMA patients and 13 age-matched controls were enrolled in this prospective, longitudinal study. All participants underwent MRI imaging including measurements of Dixon-based PDFF and DTI of the sciatic nerve. SMA patients furthermore underwent measurements of muscle water T2 (T2w) of the biceps femoris muscle (BFM) and quadriceps femoris muscle (QFM). Ten participants returned for a second scan six months later. MRI parameter were correlated with clinical data. All patients were on nusinersen treatment.

Results

There were significantly higher intramuscular fat fractions in the BFM and QFM of SMA patients compared to healthy controls at baseline and after 6 months. Furthermore, T2 values significantly correlated positively with intramuscular fat fractions. The Hammersmith functional motor scale significantly correlated with the QFM’s intramuscular fat fractions. DTI scans of the sciatic nerve were not significantly different between the two groups.

Conclusion

This study demonstrates that, water T2 mapping and Dixon-based PDFF estimation may distinguish between adult SMA patients and controls, due to massive intramuscular fat accumulation in SMA. More extensive long-term studies are warranted to further evaluate these two modalities as surrogate markers in SMA patients during treatment.
An advanced bipolar device helps reduce the rate of postoperative pancreatic fistula in laparoscopic gastrectomy for gastric cancer patients: a propensity score-matched analysis
Authors: Shibao Kazunori , Honda Shinsaku , Adachi Yasuhiro , Kohi Shiro , Kudou Yuzan , Matayoshi Nobutaka , Sato Nagahiro , Hirata Keiji
Published: October 2022

Background

Advanced bipolar devices (ABD; e.g., LigaSure™) have a lower blade temperature than ultrasonically activated devices (USAD; e.g., Harmonic® and Sonicision™) during activation, potentially enabling accurate lymph node dissection with less risk of postoperative pancreatic fistula (POPF) due to pancreatic thermal injury in laparoscopic gastrectomy. Therefore, we compared the efficacy and safety of ABD and USAD in laparoscopic gastrectomy for gastric cancer patients.

Methods

A retrospective cohort study was conducted on patients who underwent laparoscopic distal gastrectomy (LDG) between August 2008 and September 2020. A total of 371 patients were enrolled, and short-term surgical outcomes, including the incidence of ISGPF grades B and C POPF, were compared between ABD and USAD. The risk factors for POPF in LDG were investigated by univariate and multivariate analyses.

Results

A propensity score-matching algorithm was used to select 120 patients for each group. The POPF rate was significantly lower (0.8 vs. 9.2%, p < 0.001), the morbidity rate was lower (13.3 vs. 28.3%, p < 0.001), the length of postoperative hospitalization was shorter (14 vs. 19 days, p < 0.001), and the lymph node retrieval rate was higher (34 vs. 26, p < 0.001) with an ABD than with a USAD. There were no mortalities in either group. A multivariate analysis showed that a USAD was the only independent risk factor with a considerably high odds ratio for the occurrence of POPF (USAD/ABD, odds ratio 8.38, p = 0.0466).

Conclusion

An ABD may improve the safety of laparoscopic gastrectomy for gastric cancer patients.
Clues of wildfire-induced geotechnical changes in volcanic soils affected by post-fire slope instabilities
Authors: Peduto Dario , Iervolino Luca , Esposito Giuseppe , Foresta Vito , Matano Fabio , Masi Rocco
Published: October 2022

Wildfires can significantly affect mountain hillslopes through the combustion of trees and shrubs and changes in soil properties. The type and magnitude of the associated post-fire effects depend on several factors, including fire severity and soil physical–mechanical-hydraulic features that, coupled with climate and topographic conditions, may cause increased runoff, erosion, and slope instability as consequence of intense rainfall. The post-fire response of slopes is highly site-specific. Therefore, in situ surveys and laboratory tests are needed to quantify changes in key soil parameters. The present study documents the post-fire physical and hydromechanical properties of pyroclastic topsoil collected from three test sites that suffered wildfires and rainfall-induced post-fire events in 2019 and 2020 in the Sarno Mountains (Campania Region, southern Italy). The tested pyroclastic soils in burned conditions show (i) no significant changes in grain size distribution, soil organic matter, and specific gravity; (ii) a deterioration in shear strength in terms of decreased soil cohesion caused by the fire-induced weakening of root systems; and (iii) a decrease in hydraulic conductivity. Accordingly, it can be argued that the documented post-fire erosion responses were mainly caused by the reduced cohesion and hydraulic conductivity of the burned topsoil layer, as well as by the loss of vegetation cover and the deposition of fire residues. Although deserving further deepening, this study can represent the necessary background for understanding the initiation mechanism of post-fire erosion processes in the analyzed area and on several natural slopes under similar conditions.
The effect of selective decontamination on the intestinal microbiota as measured with IS-pro: a taxonomic classification tool applicable for direct evaluation of intestinal microbiota in clinical routine
Authors: van Doorn-Schepens M. L. M. , Abis G. S. A. , Oosterling S. J. , van Egmond M. , Poort L. , Stockmann H. B. A. C. , Bonjer H. J. , Savelkoul P. H. M. , Budding A. E.
Published: October 2022

Selective decontamination of the digestive tract (SDD) is aimed at elimination of potential pathogenic microorganisms. In this study, the effect of SDD on gut microbiota was evaluated in a large homogenous group of elective colorectal cancer surgery patients. Rectal swabs were taken from 118 patients undergoing colorectal surgery. These patients were randomly assigned to receive perioperative SDD or to the control group (no SDD). Rectal swabs were taken prior to surgery, 3 days after commencing administration of SDD. Gut microbial profiles were obtained with the IS-pro technique, a standardized microbiota profiling assay applicable in clinical routine. Differences in abundance for different taxonomical groups and diversity between the groups were assessed. Unsupervised and supervised classification techniques were used to assess microbial signatures, differentiating between the SDD group and the control group. Patients in the SDD group had different gut microbial signatures than in the control group, also in phyla that are not a target for SDD.Escherichia coli,Sutterellaspp.,Faecalibacterium prausnitzii, andStreptococcusspp. were the species that differed the most between the two groups. The SDD group showed clustering into two subgroups. In one subgroup, a decrease in Proteobacteria was observed, whereas the other subgroup showed a shift in Proteobacteria species. This study shows that SDD not only decreases colonization of the gastrointestinal tract with potential pathogenic Gram-negative microorganisms, but also reduces the abundance of normal colonizers of our gastrointestinal system and leads to a shift in total microbiota composition.
Accelerating electric vehicle adoption: techno-economic assessment to modify existing fuel stations with fast charging infrastructure
Authors: Ghosh Nilanshu , Mothilal Bhagavathy Sivapriya , Thakur Jagruti
Published: October 2022

With the increasing electric vehicle (EV) penetration, there arises an immediate need for charging infrastructure. In the future, the electrification of transportation will reduce the requirement of existing fuel stations, thereby rendering them obsolete. However, they are best suited to cater to the charging demand of EVs as the drivers are accustomed to the locations and the incremental cost of providing this service will be lower. In this paper, we propose a novel methodology to assess the techno-economic feasibility of retrofitting an existing fuel station with EV charging infrastructure also known as Electric Vehicle Supply Equipment (EVSE). To further enhance the value proposition, the potential of integrating Battery Energy Storage System (BESS) with EV charging infrastructure, which results in the reduction of grid connection costs, is studied. The sustainability of the proposed system is improved with additional onsite Photovoltaic (PV) generation. The proposed methodology is implemented for the UK as a case study. The configurations in this study are designed based on the technical considerations involved in retrofitting a typical fuel station as a fast charging facility for EVs. From the results, it is observed that the configurations with 4 EVSE, 1 BESS, and 8 h of operation and the configuration with 4 EVSE, 1 BESS, and 1 PV system for 8 h of operation are economically viable. The abovementioned configurations are the most economically feasible configurations in terms of the Net Present Value (NPV), Internal Rate of Return (IRR) and the Discounted Payback Period (DPP) amongst the other configurations considered in this study. The proposed methodology indicates that though the connection cost is the dominant factor affecting the feasibility, the use of BESS with or without PV can reduce the connection cost by almost 90% depending on the capacity of BESS. The methodology acts as a decision support tool to select a techno-economically feasible configuration of EVSE, BESS, and PV.

Graphical abstract
Sieve bootstrapping the memory parameter in long-range dependent stationary functional time series
Authors: Shang Han Lin
Published: October 2022

We consider a sieve bootstrap procedure to quantify the estimation uncertainty of long-memory parameters in stationary functional time series. We use a semiparametric local Whittle estimator to estimate the long-memory parameter. In the local Whittle estimator, discrete Fourier transform and periodogram are constructed from the first set of principal component scores via a functional principal component analysis. The sieve bootstrap procedure uses a general vector autoregressive representation of the estimated principal component scores. It generates bootstrap replicates that adequately mimic the dependence structure of the underlying stationary process. We first compute the estimated first set of principal component scores for each bootstrap replicate and then apply the semiparametric local Whittle estimator to estimate the memory parameter. By taking quantiles of the estimated memory parameters from these bootstrap replicates, we can nonparametrically construct confidence intervals of the long-memory parameter. As measured by coverage probability differences between the empirical and nominal coverage probabilities at three levels of significance, we demonstrate the advantage of using the sieve bootstrap compared to the asymptotic confidence intervals based on normality.
A social robot-based platform for health behavior change toward prevention of childhood obesity
Authors: Triantafyllidis Andreas , Alexiadis Anastasios , Elmas Dimosthenis , Gerovasilis Georgios , Votis Konstantinos , Tzovaras Dimitrios
Published: October 2022

Childhood obesity is a major public health challenge which is linked with the occurrence of diseases such as diabetes and cancer. The COVID-19 pandemic has forced changes to the lifestyle behaviors of children, thereby making the risk of developing obesity even greater. Novel preventive tools and approaches are required to fight childhood obesity. We present a social robot-based platform which utilizes an interactive motivational strategy in communication with children, collects self-reports through the touch of tangible objects, and processes behavioral data, aiming to: (a) screen and assess the behaviors of children in the dimensions of physical activity, diet, and education, and (b) recommend individualized goals for health behavior change. The platform was integrated through a microservice architecture within a multi-component system targeting childhood obesity prevention. The platform was evaluated in an experimental study with 30 children aged 9–12 years in a real-life school setting, showing children’s acceptance to use it, and an 80% success rate in achieving weekly personal health goals recommended by the social robot-based platform. The results provide preliminary evidence on the implementation feasibility and potential of the social robot-based platform toward the betterment of children’s health behaviors in the context of childhood obesity prevention. Further rigorous longer-term studies are required.
Learning with cone-based geometric models and orthologics
Authors: Leemhuis Mena , Özçep Özgür L. , Wolter Diedrich
Published: October 2022

Recent approaches for knowledge-graph embeddings aim at connecting quantitative data structures used in machine learning to the qualitative structures of logics. Such embeddings are of a hybrid nature, they are data models that also exhibit conceptual structures inherent to logics. One motivation to investigate embeddings is to design conceptually adequate machine learning (ML) algorithms that learn or incorporate ontologies expressed in some logic. This paper investigates a new approach to embedding ontologies into geometric models that interpret concepts by geometrical structures based on convex cones. The ontologies are assumed to be represented in an orthologic, a logic with a full (ortho)negation. As a proof of concept this cone-based embedding was implemented within two ML algorithms for weak supervised multi-label learning. Both algorithms rely on cones but the first addresses ontologies expressed in classical propositional logic whereas the second addresses a weaker propositional logic, namely a weak orthologic that does not fulfil distributivity. The algorithms were evaluated and showed promising results that call for investigating other (sub)classes of cones and developing fine-tuned algorithms based on them.
Sim-to-real transfer and reality gap modeling in model predictive control for autonomous driving
Authors: Daza Iván García , Izquierdo Rubén , Martínez Luis Miguel , Benderius Ola , Llorca David Fernández
Published: October 2022

The main challenge for the adoption of autonomous driving is to ensure an adequate level of safety. Considering the almost infinite variability of possible scenarios that autonomous vehicles would have to face, the use of autonomous driving simulators is becoming of utmost importance. Simulation suites allow the used of automated validation techniques in a wide variety of scenarios, and enable the development of closed-loop validation methods, such as machine learning and reinforcement learning approaches. However, simulation tools suffer from a standing flaw in that there is a noticeable gap between the simulation conditions and real-world scenarios. Although the use of simulators powers most of the research around autonomous driving, and is generally used within all domains it is divided into, there is an inherent source of error given the stochastic nature of activities performed in real world, which are unreplicable in computer environments. This paper proposes a new approach to assess the real-to-sim gap for path tracking systems. The aim is to narrow down the sources of error between simulation results and real-world conditions, and to evaluate the performance of the simulation suite in the design process by employing the information extracted from gap analysis, which adds a new dimension of development against other approaches for autonomous driving. A real-time model predictive controller (MPC) based on adaptive potential fields was developed and validated using the CARLA simulator. Both the path planning and vehicle control systems where tested in real traffic conditions. The error between the simulator and the real data acquisition was evaluated using the Pearson correlation coefficient (PCC) and the max normalized cross-correlation (MNCC). The controller was further evaluated on a process of sim-to-real transfer, and was finally tested both in simulation and real traffic conditions. A comparison was performed against an optimal-control ILQR-based model predictive controller was carried out to further showcase the validity of this approach.
Behavioral and Socio-Emotional Disorders in Intellectual Giftedness: A Systematic Review
Authors: Tasca Ilaria , Guidi Michele , Turriziani Patrizia , Mento Giovanni , Tarantino Vincenza
Published: October 2022

This work systematically reviewed past literature to investigate the association between intellectual giftedness and socio-emotional and/or behavioral disorders. Nineteen studies met the inclusion criteria, 17 of which have children and/or adolescents as participants, and 12 have a non-gifted control group. Socio-emotional problems, such as withdrawal, were found in 3 out of 8 studies; internalizing disorders, such as anxiety, were found in 5 out of 9; externalizing disorders, such as hyperactivity, were found in 3 out of 5. The most investigated comorbidity was attention-deficit/hyperactivity disorder. A univocal conclusion on the relationship between intellectual giftedness and socio-emotional/behavioral problems cannot be drawn, principally because of the heterogeneity of participants’ age, informants, and instruments. The review highlights the need for future studies to use multi-informant and comprehensive assessments, to reach more robust findings, and suggests that age and discrepancy between verbal and non-verbal intellectual abilities should be considered critical factors.
Comparing ϕ and the F-measure as performance metrics for software-related classifications
Authors: Lavazza Luigi , Morasca Sandro
Published: October 2022

Context

The F-measure has been widely used as a performance metric when selecting binary classifiers for prediction, but it has also been widely criticized, especially given the availability of alternatives such as ϕ (also known as Matthews Correlation Coefficient).

Objectives

Our goals are to (1) investigate possible issues related to the F-measure in depth and show how ϕ can address them, and (2) explore the relationships between the F-measure and ϕ.

Method

Based on the definitions of ϕ and the F-measure, we derive a few mathematical properties of these two performance metrics and of the relationships between them. To demonstrate the practical effects of these mathematical properties, we illustrate the outcomes of an empirical study involving 70 Empirical Software Engineering datasets and 837 classifiers.

Results

We show that ϕ can be defined as a function of Precision and Recall, which are the only two performance metrics used to define the F-measure, and the rate of actually positive software modules in a dataset. Also, ϕ can be expressed as a function of the F-measure and the rates of actual and estimated positive software modules. We derive the minimum and maximum value of ϕ for any given value of the F-measure, and the conditions under which both the F-measure and ϕ rank two classifiers in the same order.

Conclusions

Our results show that ϕ is a sensible and useful metric for assessing the performance of binary classifiers. We also recommend that the F-measure should not be used by itself to assess the performance of a classifier, but that the rate of positives should always be specified as well, at least to assess if and to what extent a classifier performs better than random classification. The mathematical relationships described here can also be used to re-interpret the conclusions of previously published papers that relied mainly on the F-measure as a performance metric.
Climate change threats to cultural and natural heritage UNESCO sites in the Mediterranean
Authors: Kapsomenakis J. , Douvis C. , Poupkou A. , Zerefos S. , Solomos S. , Stavraka T. , Melis N. S. , Kyriakidis E. , Kremlis G. , Zerefos C.
Published: October 2022

The study presents a time-dependent analysis of threats from man-made climate change at 244 UNESCO cultural and natural heritage sites in the Mediterranean. The hazards in our research are estimated by indices based on extremes of heat, fire weather conditions, heavy rainfall days, frost days, changes in mean sea level and aridity at each site. These indices were calculated from regional EUROCORDEX simulations, cover the period 1971–2100 and refer to two IPCC emission scenarios, namely RCP4.5 and RCP8.5. A combined threat index was next calculated, as explained in the text, together with its synergy with local exposure geophysical threats, such as seismicity, topography and proximity to forests and seas. All indices related to man-made climate change show an overall increasing trend from present to the end of the twenty-first century. Some of these increasing trends are intensified after the 2030s and 2040s, except for the case of the days with frost. As the global warming evolves, in both IPCC scenarios studied, the combined threat to the majority of UNESCO sites studied increases. Notable is the amplification of the threat at sites vulnerable to seismic activity and to other local or regional topography and geophysical regional characteristics. Our conclusion is that the majority of heritage sites in the Mediterranean are vulnerable to an increasing rate of threats from man-made global warming and extreme events. Seismic activity is magnifying these threats only at the sites in which that additional hazard applies. Based on the proposed combined threat index, for the worst-case scenario (RCP8.5) 35 monument sites fall within the “high hazard” and 12 sites fall under the category “extreme hazard”.
Towards Formalising Schutz’ Axioms for Minkowski Spacetime in Isabelle/HOL
Authors: Schmoetten Richard , Palmer Jake E. , Fleuriot Jacques D.
Published: October 2022

Special relativity is a cornerstone of modern physical theory. While a standard coordinate model is well known and widely taught today, multiple axiomatic systems for SR have been constructed over the past century. This paper reports on the formalisation of one such system, which is closer in spirit to Hilbert’s axiomatic approach to Euclidean geometry than to the vector space approach employed by Minkowski. We present a mechanisation in Isabelle/HOL of the system of axioms as well as theorems relating to temporal order. Some proofs are discussed, particularly where the formal work required additional steps, alternative approaches or corrections to Schutz’ prose.
Role of planar faults in martensite formation in nano-polycrystalline iron by molecular dynamics simulation
Authors: Karewar Shivraj , Hidalgo Javier , Sietsma Jilt , Santofimia Maria J.
Published: October 2022

The martensitic transformation in pure Fe and its alloys has been studied over many decades. Several theoretical models have been proposed to describe the atomic motion that leads to the fcc-to-bcc martensitic transformation. However, such models do not account for the effect of pre-existing planar defects such as twin boundaries and stacking faults, present in the high-temperature austenite phase prior to the transformation process. This work systematically studies the role of nano-spaced planar faults with different inter-spacing on the martensitic transformation using molecular dynamics simulations. Research shows that the investigated planar defects affect the nucleation and growth mechanisms during martensite formation, the morphology of the resulting microstructure, the specific atomic path leading to the phase transformation, and the martensite start temperatures. Martensite variants were identified by the analysis of the atomic shears and slip systems during the transformation process. A crystallographic analysis is done to explain the existence of different shear mechanisms of martensite transformation at different locations in the fcc austenite. The present investigation provides fundamental insights into the martensitic transformation process in presence of pre-existing planar defects and can be applied to other material systems, e.g., Fe alloys.
Cyberbullying and Gambling Disorder: Associations with Emotion Regulation and Coping Strategies
Authors: Estévez Ana , Macía Laura , López-González Hibai , Momeñe Janire , Jauregui Paula , Etxaburu Nerea , Granero Roser , Fernández-Aranda Fernando , Mestre-Bach Gemma , Vintró-Alcaraz Cristina , Munguía Lucero , Baenas Isabel , Mena-Moreno Teresa , Mora-Maltas Bernat , Valenciano-Mendoza Eduardo , Jiménez-Murcia Susana
Published: October 2022

The presence of unsuitable coping and emotion regulation strategies in young populations with gambling disorder (GD) and in those who have experienced cyberbullying victimization has been suggested. However, this association has not been explored in depth. In this study, our aim was to analyze individual differences in emotion regulation, coping strategies, and substance abuse in a clinical sample of adolescents and young adult patients with GD (n = 31) and in a community sample (n = 250). Furthermore, we aimed to examine the association between cyberbullying and GD. Participants were evaluated using the Cyberbullying Questionnaire-Victimization, the Canadian Adolescent Gambling Inventory, the Coping Strategies Inventory, the Difficulties in Emotion Regulation Scale, the Alcohol Use Disorders Identification Test and the Drug Use Disorders Identification Test. Structural Equation Modeling was used to explore associations between these factors in a community sample and in a clinical group. In both groups, exposure to cyberbullying behaviors was positively associated with higher emotion dysregulation and the use of maladaptative coping styles. Our findings uphold that adolescents and young adults who were victims of cyberbullying show difficulties in emotion regulation and maladaptive coping strategies when trying to solve problems. The specific contribution of sex, age, gambling severity, emotion regulation, and coping strategies on cyberbullying severity is also discussed. Populations at vulnerable ages could potentially benefit from public prevention policies that target these risk factors.
The effect of functionalized hydroxyapatite on the thermal degradation behaviour and flammability of polyoxymethylene copolymer
Authors: Król-Morkisz Klaudia , Byczyński Łukasz , Majka Tomasz M. , Pielichowski Krzysztof , Pielichowska Kinga
Published: October 2022

In this work, the effect of functionalized hydroxyapatite (HAp-g-PEG) on the thermal degradation behaviour and flammability of polyoxymethylene copolymer (POM_C) was investigated. Organic–inorganic hybrid additive, obtained by grafting of poly(ethylene glycol) on HAp surface using 1,6-hexamethylene diisocyanate as a linker, has been incorporated into POM matrix through an extrusion process. TG analyses show that the incorporation of HAp-g-PEG into POM_C leads to the significant improvement in the thermal stability of the polymer matrix. This is an important finding as POM, being an engineering polymer, suffers from a relatively low thermal stability that limits processing options to develop advanced composite materials. Based on TG results kinetic parameters of the thermal degradation process using Friedman isoconversional method and nonlinear regression method have been calculated; an increase in activation energy of POM degradation process after incorporation of HAp-g-PEG has been found. Thermoanalytical analyses (TG-FTIR/MS) show that incorporation of HAp-g-PEG has no significant effect on the composition of the thermal degradation products. Flammability investigations showed small effect of HAp-g-PEG 600 on the burning time and rate, however, there was a significant reduction in the amount of dripping during the material’s burning process.
Ethical, legal, and social aspects of symptom checker applications: a scoping review
Authors: Müller Regina , Klemmt Malte , Ehni Hans-Jörg , Henking Tanja , Kuhnmünch Angelina , Preiser Christine , Koch Roland , Ranisch Robert
Published: October 2022

Symptom Checker Applications (SCA) are mobile applications often designed for the end-user to assist with symptom assessment and self-triage. SCA are meant to provide the user with easily accessible information about their own health conditions. However, SCA raise questions regarding ethical, legal, and social aspects (ELSA), for example, regarding fair access to this new technology. The aim of this scoping review is to identify the ELSA of SCA in the scientific literature. A scoping review was conducted to identify the ELSA of SCA. Ten databases (e.g., Web of Science and PubMed) were used. Studies on SCA that address ELSA, written in English or German, were included in the review. The ELSA of SCA were extracted and synthesized using qualitative content analysis. A total of 25,061 references were identified, of which 39 were included in the analysis. The identified aspects were allotted to three main categories: (1) Technology; (2) Individual Level; and (3) Healthcare system. The results show that there are controversial debates in the literature on the ethical and social challenges of SCA usage. Furthermore, the debates are characterised by a lack of a specific legal perspective and empirical data. The review provides an overview on the spectrum of ELSA regarding SCA. It offers guidance to stakeholders in the healthcare system, for example, patients, healthcare professionals, and insurance providers and could be used in future empirical research to investigate the perspectives of those affected, such as users.
Tectonic Regime as a Control Factor for Crustal Fault Zone (CFZ) Geothermal Reservoir in an Amagmatic System: A 3D Dynamic Numerical Modeling Approach
Authors: Duwiquet H. , Magri F. , Lopez S. , Guillon T. , Arbaret L. , Bellanger M. , Guillou-Frottier L.
Published: October 2022

Crustal fault zones provide interesting geological targets for high-temperature geothermal energy source in naturally deep-fractured basement areas. Field and laboratory studies have shown the ability of these systems to let fluid flow down to the brittle–ductile transition. However, several key questions about exploration still exist, in particular the fundamental effect of tectonic regimes on fluid flow in fractured basement domains. Based on poro-elasticity assumption, we considered an idealized 3D geometry and realistic physical properties. We examined a model with no tectonic regime (benchmark experiment) and a model with different tectonic regimes, namely a compressional, an extensional and a strike-slip tectonic regime. Compared to the benchmark experiment, the results demonstrate that different tectonic regimes cause pressure changes in the fault/basement system. The tectonic-induced pressure changes affect convective patterns, onset of convection as well as the spatial extent of thermal plumes and the intensity of temperature anomalies. Driven by poro-elastic forces, temperature anomalies around vertical faults in a strike-slip tectonic regime have a spatial extent that should be considered in preliminary exploratory phases.
Are OMERACT recommendations followed in clinical trials on fibromyalgia? A systematic review of patient-reported outcomes and their measures
Authors: Döhmen Annika , Kock Milan , Fischer Felix , Rose Matthias , Obbarius Alexander , Klapproth Christoph Paul
Published: October 2022

Purpose

Patient-Reported Outcomes (PROs) and its measures (PROMs) are key to outcome assessment in Fibromyalgia (FM) trials. The aim of this review was to investigate which domains and instruments were assessed in recent FM trials and to compare them to recommendations by the Outcome Measures in Rheumatology (OMERACT) initiative. In addition, we investigated the overlap with a generic health assessment approach, i.e. eight domains suggested by the Patient-Reported Outcome Measurement Information System® (PROMIS®).

Methods

In compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature search in scientific databases including PubMed, PsycInfo, and Embase was conducted to identify studies that assessed at least two dimensions of health-related quality of life (HRQoL) from 2015 to June 2022. Non-randomized and randomized controlled trials were included in the analysis. We extracted PROs and PROMs used in each study.

Results

From 1845 identified records, 107 records out of 105 studies met the inclusion criteria. Studies investigated 50 PROs using 126 different PROMs. Most frequently assessed domains were pain, depression, fatigue, and anxiety (> 95% of the studies). The disease-specific FIQ was the most frequently applied PROM (82%). Overall, only 9% of the studies covered all domains deemed mandatory by OMERACT. Very few studies covered all eight generic health domains suggested by PROMIS.

Conclusion

The majority of trials covered most OMERACT domains or generic PROMIS health domains. There was, however, great variability in the instruments used to assess the domains, which points at a limited degree of standardization in the field.
College Students’ Perceptions of Ambiguous Hook-ups Involving Alcohol Intoxication
Authors: Celniker Jared B. , Rode Jacob B. , Anderson Katherine B. , Ma Brianna , Ditto Peter H.
Published: October 2022

Alcohol intoxication is a prevalent feature of university life and campus sexual assault cases. While previous research has examined how students perceive obvious cases of assault, less is known about how students evaluate more ambiguous sexual scenarios—such as those including two intoxicated individuals. In three survey experiments with college students (N = 990), we examined how manipulating the intoxication (sober vs. drunk) of a man accused of assault (the respondent) influenced perceptions of a hook-up scenario involving an intoxicated woman. Although university policies indicate that respondent intoxication should not influence evaluations of these scenarios, we hypothesized that students would be influenced by cues of respondent intoxication when making judgments of the hook-up and the individuals involved. Students reported that the hook-up was a sexual assault more often when the respondent was sober compared to when he was drunk, and they found sober respondents more responsible for the encounter than drunk respondents. Although effect sizes fluctuated across studies, an internal meta-analysis found evidence of significant (but modest) aggregate effects. Furthermore, perceptions of the respondent’s agency mediated the effects of intoxication on perceptions of respondent responsibility (Studies 2 & 3). We also manipulated whether the respondent should have reasonably known the complainant was drunk (Studies 1 & 2) and whether the complainant or the complainant’s friend reported the incident (Study 3), but these manipulations had little effect on students’ perceptions of the vignettes. We discuss how our findings can guide future research and consider implications of our results for university stakeholders.
Generalizing the constrained equal awards rule
Authors: Dietzenbacher Bas
Published: October 2022

This paper studies axiomatic characterizations of the constrained equal awards rule for bankruptcy problems. We show that many results apply in a much more general context than for which they are originally formulated. In particular, we generalize several axiomatic characterizations based on symmetry, sustainability, and consistency to the domain of bankruptcy problems with nontransferable utility.