bluuebunny/crossref_metadata_2025 huggingface dataset:
Engaging domestic abuse practitioners and survivors in a review of outcome tools – reflections on differing priorities
Authors: Clark Sigrún Eyrúnardóttir , Kimber Melissa , Downes Lucy , Feder Gene , Fulton Elaine , Howarth Emma , Johns Karen , Lindenberg Ursula , d’Oliveira Ana Flavia , Shaheen Amira , Vindrola-Padros Cecilia , Powell Claire
Published: May 2023

Researchers often develop and decide upon the measurement tools for assessing outcomes related to domestic abuse interventions. However, it is known that clients, service providers and researchers have different ideas about the outcomes that should be measured as markers of success. Evidence from non-domestic abuse sectors indicates that engagement of service providers, clients and researchers contributes to more robust research, policy and practice. We reflect on what we have learnt from the engagement of practitioners and domestic abuse survivors in a review of domestic abuse measurement tools where there were clear differences in priorities between survivors, practitioners and researchers about the ideal measurement tools. The purpose of this reflective article is to support the improvement of future outcome measurement from domestic abuse interventions, while ensuring that domestic abuse survivors do not relive trauma because of measurement.
Trabalho doméstico infantil e ensino e aprendizado da leitura no Brasil no final do Século XIX e início do século XX
Authors: Peres Eliane
Published: May 2023

Este artigo analisa anúncios de jornais, coletados na Hemeroteca Digital da Biblioteca Nacional, do período entre as últimas décadas do século XIX e a primeira do século XX, em que crianças são solicitadas ou oferecidas ao trabalho, em especial ao trabalho doméstico, e nos quais é referido a possibilidade de que pudessem aprender a ler ou “terminar de aprender a ler”. Em um contexto de diversas mudanças no Brasil, as demandas do ler, escrever e contar cresceram expressivamente. O principal argumento desenvolvido é que, no período mencionado, o trabalho, notadamente o doméstico, foi um espaço no qual uma parcela da infância brasileira aprendeu a ler e a escrever. A necessidade de trabalho e de aprendizado de um ofício, o crescimento urbano, a insuficiência de escolas, as condições de vida das crianças nascidas livres a partir de 1871 e o pós-abolição estão entre as razões que explicam essa realidade.
As práticas do cuidado e a criação do Curso de Enfermagem da UFS: motivações e razões para contar esta história
Authors: Silva Elizabete Farias Lima , Souza Josefa Eliana
Published: May 2023

O presente estudo inquieta-se por compreender a motivação e panorama social que foram determinantes para o aprimoramento das práticas do cuidar e a criação do curso de graduação em enfermagem da UFS, um recorte entre 1931 a 1979, da criação do Departamento de saúde pública de Sergipe até a formação superior da primeira turma. Em que pese dar foco à trajetória desta sociedade, suas práticas do cuidado em enfermagem, além de conhecer especificidades e possíveis fenômenos que potencializaram e consubstanciaram às reflexões sobre essas práticas e desdobramentos contribuintes para a criação deste Curso. O artigo concluiu que o aprimoramento das práticas do cuidado em enfermagem e a criação do referido curso na UFS desvelaram um percurso fecundo e necessário à consolidação de uma prática sedimentada nas diversas vertentes do conhecimento, neste texto, delimitadas entre o empírico e o científico.
Postural sway is not affected by estrogen fluctuations during the menstrual cycle
Authors: Reschechtko Sasha , Nguyen Thuy Ngoc , Tsang Michelle , Giltvedt Kristine , Kern Mark , Hooshmand Shirin
Published: May 2023

When people stand still, they exhibit a phenomenon called postural sway, or spontaneous movement of the body's center of pressure, which is related to balance control. In general females show less sway than males, but this difference only begins to appear around puberty, pointing to different levels of sex hormones as one potential mechanism for sway sex differences. In this study, we followed cohorts of young females using oral contraceptives (n = 32) and not using oral contraceptives (n = 19), to investigate associations between estrogen availability and postural sway. All participants visited the lab four times over the putative 28‐day menstrual cycle. At each visit, we performed blood draws to measure plasma estrogen (estradiol) levels, and tests of postural sway using a force plate. During late follicular and mid‐luteal phase, estradiol levels were lower in participants using oral contraceptives (mean differences [95% CI], respectively: −231.33; [−800.44, 337.87]; −613.26; [−1333.60, 107.07] pmol/L; main effect p < 0.001), reflecting expected consequences of oral contraceptive use. Despite these differences, postural sway was not significantly different between participants who were using oral contraceptives and participants who were not (mean difference: 2.09 cm; 95% CI = [−1.05, 5.22]; p = 0.132). Overall, we found no significant effects of the estimated menstrual cycle phase—or absolute levels of estradiol—on postural sway.
Diagnosis of primary amoebic meningoencephalitis by metagenomic next-generation sequencing: A case report
Authors: Che Xiujuan , He Zhiyi , Tung Tao-Hsin , Xia Han , Lu Zhibao
Published: May 2023

Primary amoebic meningoencephalitis (PAM) caused by Naegleria fowleri is a fatal infection with a mortality rate of more than 95%, despite advances in antimicrobial chemotherapy and supportive care. Initial manifestations of PAM are indistinguishable from bacterial meningitis. Prompt diagnosis and antifungal treatment may help decline the overall mortality. Here we present a case of a 38-year-old man transferred to our hospital due to mild headache, which deteriorated quickly. Severe increased intracranial pressure was found. The cerebrospinal fluid (CSF) was yellowish with significantly increased leukocyte and protein. Smear and culture were negative. The patient was first diagnosed with pyogenic meningoencephalitis. However, the symptoms deteriorated. Metagenomic next-generation sequencing (mNGS) of CSF was applied and finally confirmed N. fowleri as the protist pathogen within 24 h. However, due to the time cost of sampling and transportation (2 days), the diagnosis came too late, and the patient passed away 1 day before. In summary, mNGS is a rapid and accurate diagnostic method for clinical practices, especially for rare central nervous system infections. It should be used as quickly as possible for acute infections, such as PAM. All aspects of patient interrogation and prompt identification should be paramount to ensure appropriate treatment and decline the overall mortality.
Effects of NM23 transfection of human gastric carcinoma cells in mice
Authors: Liang Na , Li Chunming , Zhang Neng , Xu Qiang , Zou Shengnan , Zhang Meng , Si Shuyao , Zeng Li
Published: May 2023

Gastric carcinoma is a frequent malignant tumor worldwide. NM23 plays an important role in pathological processes, including in the occurrence and development of tumors. The purpose of this study is to examine the effect of NM23 transfection of human gastric carcinoma cells (BGC-823) on growth and metastases of BGC-823 abdominal cancer xenografts in nude mice. BGC-823 cells were transfected with an adenovirus vector for NM23 (NM23-OE), transfected with an empty vector (NC), or were not transfected (Ctrl). Eighteen female BALB/c-nu mice were randomly divided into three groups (six per group) according to the type of BGC-823 cells administered by intraperitoneal injection. After 2 weeks, necropsies of mice were performed, abdominal circumferences were measured, and abdominal cavities were searched by ultrasound. In order to observe the xenografts in nude mice, there were gross macroscopic observations and microscopic observations. In addition, immunohistochemical analysis and western blot of NM23 were also performed. Green fluorescence in the NM23-OE and NC cells indicated successful transfection. The multiplicity of infection is 80%. A comparison of the three groups of mice indicated the NM23-OE group had positive conditions (abdominal circumferences: 81.83 ± 2.40 mm), but the other groups had negative conditions and enlarged abdomens (NC: 90.83 ± 2.32 mm; Ctrl: 92.67 ± 2.07 mm). Ultrasound observations confirmed large tumors in the NC and Ctrl groups, but did not find in the NM23-OE group. There were no obvious ascites in the NM23-OE group, but the cytological examination of ascites exfoliation in NC and Ctrl groups indicated that there were large and deep-stained gastric carcinoma cells. Tumor expression of NM23 was greater in the NM23-OE group than in the NC and Ctrl groups (both p < 0.05). In conclusion, transfection of BCG-823 cells with NM23 rather than an empty vector (NC) or no vector (Ctrl) led to reduced growth and metastases of abdominal cancer xenografts in nude mice.
An efficient and green synthesis of 2-phenylquinazolin-4(3H)-ones via t-BuONa-mediated oxidative condensation of 2-aminobenzamides and benzyl alcohols under solvent- and transition metal-free conditions
Authors: Nguyen Vy T. B. , Tran Dat P. , Nguyen Tung T. , Nguyen Khoa D. , Le Ha V.
Published: May 2023

Quinazolinone synthesis usually requires employing sensitive substrates, hazardous solvents, large excess oxidants, and expensive catalysts. In this study, an efficient and environmentally benign pathway was developed to synthesize 2-phenylquinazolin-4(3H)-one via oxidative coupling between commercially available and stable chemicals, including 2-aminobenzamide and benzyl alcohol without toxic oxidizing agents and transition-metal catalysts. A high yield of the desired product (up to 84%) was obtained at 120°C for 24 h in the presence of oxygen as a green oxidant and t-BuONa as a base. Importantly, the study scope was expanded toward successfully producing various 2-phenylquinazolin-4(3H)-one derivatives in moderate-to-good yields. Furthermore, control experiments proposed that the conversion involved the initial partial oxidation of benzyl alcohol to the benzaldehyde intermediate under basic conditions, followed by the condensation, intramolecular nucleophilic addition, and oxidative dehydrogenation to 2-phenylquinazolin-4(3H)-one.
Comparative study of structural, optical and electrical properties variation of pure, (Ag, Mg) doped and co-doped ZnO nanostructured thin films
Authors: Lekoui Fouaz , Amrani Rachid , Hassani Salim , Garoudja Elyes , Filali Walid , Oussalah Slimane , Dergham Driss , Akkari Hocine , Sengouga Nouredine
Published: May 2023

Nanostructured thin films are one of the most valuable types of industrial semiconductors for a variety of optoelectronics and optical device applications, having recently been used as a transparent conductive oxide in solar cells. In this work, nanostructured thin films of pure ZnO, Ag doped ZnO, Mg doped ZnO and Ag–Mg co-doped ZnO were successfully synthesized on silicon and glass substrates, using rapid thermal evaporation. The impact of the doping elements on the surface morphology, structural, electrical, and optical properties of the deposited films were investigated. It was found that all films have polycrystalline hexagonal wurtzite structure using X-ray diffraction. Images obtained by scanning electron microscopy (SEM) revealed compact and smooth surfaces, with uniform coverage of all substrate regions. SEM images confirm the nanostructured nature of the surfaces with particle size varying as a function of doping. Raman spectroscopy showed A1(LO), E2(high) and LVM modes for all samples. The developed films’ optical transmission ranged from 74 % to 87 %, with an optical bandgap ranging from 3.09 for Mg:ZnO films to 3.8 eV for Ag:ZnO samples. Depending on the doping nature modification, these alterations were associated to structural and morphological changes in the films. All films were electrically conductive, while Ag:ZnO films exhibited the lowest resistivity value reaching 0.56 Ω cm.
About the pseudo-ternary alkali metal-thallium(I) dicyanamide systems
Authors: Reckeweg Olaf , Lissner Falk , Blaschkowski Björn , Schleid Thomas
Published: May 2023

Metathesis reactions designed to produce nominally the pseudo-ternary ATl[N(CN)2]2 compounds (A = Li, Na, K, Rb or Cs) either yielded solid solutions or separated pseudo-binary dicyanamides next to the new compounds LiTl[N(CN)2]2 and Tl0.89(1)Cs0.11(1)[N(CN)2]. Tetragonal LiTl[N(CN)2]2 (a = 724.96(2), c = 1411.77(6) pm, Z = 4) is crystallizing isotypically with LiK[N(CN)2]2 in the space group I4/mcm, while orthorhombic Tl0.89(1)Cs0.11(1)[N(CN)2] (a = 858.19(4), b = 654.22(2), c = 738.94(4) pm, Z = 4) adopts the α-K[N(CN)2]-type structure in the space group Pbcm, which Tl[N(CN)2] itself also assumes, with the unique cationic position shared by Tl+ and Cs+ in an approximate 9:1 molar ratio. The Raman spectra of the new compounds are presented and compared to those of Tl[N(CN)2], LiK[N(CN)2]2 and LiRb[N(CN)2]2.
Synthesis and characterization of diphenyl(pentachlorophenyl)phosphanegold(I) chloride
Authors: Heinrichs Peter , Stammler Hans-Georg , Mitzel Norbert W.
Published: May 2023

Diphenyl(pentachlorophenyl)phosphanegold(I) chloride was synthesized and characterized via NMR spectroscopy, elemental analysis and X-ray diffraction.
One step biogenic sugarcane bagasse mediated synthesis of gold nanoparticles and their catalytic applications in removing environmental pollutants
Authors: Naeem Muqaddas , Irfan Ahmad , Begum Robina , Farooqi Zahoor H.
Published: May 2023

Biogenic green synthesis of gold nanoparticles (Au-NPs) was carried out by utilizing fated waste product of sugarcane industry. Sugarcane bagasse extract was obtained by constant stirring of sugarcane bagasse in aqueous medium for 20 min. Synthesis of gold nanoparticles was carried out at different values of pH of the medium in order to determine the effect of pH on the formation of gold nanoparticles. Fabrication of gold nanoparticles was confirmed by UV–Vis spectroscopic analysis of the reaction mixture and XRD analysis of the sample. FTIR was used to identify different functionalities present in extract responsible for the formation of gold nanoparticles. Biogenic Au-NPs were utilized as a catalyst for the reduction/degradation of nitroarenes and organic dyes such as 4-nitrophenol (4-NP), 4-nitroaniline (4-NA), Congo red (CR), methyl red (MR), brilliant blue (BB), rhodamine B (Rh B) and methyl orange (MO). Kinetics of these reactions proves the efficiency and effectiveness of sugarcane bagasse mediated gold nano-catalysts making them an excellent tool for industrial applications.
Post-myocardial infarction treatment with resiniferatoxin modulates the expression of important genes involved in inflammation, plaque stability and angiogenesis
Authors:   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Mircea Andrei Alexandru ,   UCLA Health Arrhythmia Center, Los Angeles, CA 90095, USA
Published: May 2023

Ventricular tachycardia (VT) and ventricular fibrillation (VF) are the most frequent causes of death in the first 24 hours after myocardial infarction. Previous studies showed that depleting TRPV1 receptors with resiniferatoxin (RTX) led to a reduced risk of VT and VF post-myocardial infarction. Therefore, the question of resiniferatoxin as a cardioprotector against myocardial infarction (MI)-induced VT and VF was raised. The RNA sequence data from 3 groups of pigs, each having 4 animals (4 controls, 4 myocardial infarction - MI, and 4 RTX + MI) was analyzed through the lens of differentially expressed genes. The differential expression comparison was conducted in two ways: MI versus Control and RTX+MI versus MI. The results showed the downregulation of deleterious genes involved in inflammation and future plaque instability in the RTX group compared with the MI group. In the case of some of the genes, these findings were reinforced by obtaining the same trends in the MI versus Control group. All in all, we propose further investigation of RTX as a prophylactic method against cardiovascular complications of MI.
Analytic Induction for Social Research
Authors: Ragin Charles C.
Published: May 2023

This book explores analytic induction, an approach to the analysis of cross-case evidence on qualitative outcomes that has deep roots in sociology. A popular research technique in the early decades of empirical sociology, analytic induction differs fundamentally as a method of social research from conventional variation-based approaches. In Analytic Induction for Social Research, Charles C. Ragin demonstrates that much is gained from systematizing analytic induction. The approach he introduces here offers a new template for conducting cross-case analysis and provides a new set of tools for answering common research questions that existing methods cannot address.
A Life of Worry: Politics, Mental Health, and Vietnam’s Age of Anxiety
Authors: Tran Allen L.
Published: May 2023

In less than half a century, people in Vietnam have gone from fearing war and famine to fretting over the best cell phone plan. This shift in the landscape of people’s anxieties is the result of policies that made Vietnam the second-fastest-growing economy in the world and a triumph of late capitalist development. Yet as much as people marvel at the speed of progress, all this change— even for the better—can be difficult to handle. A Life of Worry unpacks an ethnographic puzzle. What accounts for the simultaneous increase in anxiety and economic prosperity among Ho Chi Minh City’s middle class? At a time when people around the world are turning to the pharmaceutical and wellness industries to soothe their troubled minds, it is worth asking whether these industries might be part of the problem.
Biocontrol of Bacterial Fruit Blotch by Seed Priming with Bacillus Amyloliquefaciens and Pseudomonas Fluorescens
Authors: Wang Yuxi , Qiu Yanhong , Lu Yu , Wang Xinyu , Zhang Haijun , Wu Ping , Wang Dexin , Zhang Dianpeng , Luo Laixin , Xu Xiulan
Published: May 2023

Bacterial fruit blotch (BFB), caused by the seed-transmitted pathogen Acidovorax citrulli, poses a serious threat to cucurbitaceous crops worldwide. In this study, two biocontrol bacteria strains, Bacillus amyloliquefaciens (Ba- 2) and Pseudomonas fluorescens (2P24),
with significant antagonistic activity against A. citrulli were and applied by seed priming to control BFB seed transmission. Artificially infested watermelon and melon seeds were treated with the biocontrol strains by liquid or solid matrix seed priming. The seed bio-priming effects
were evaluated under greenhouse conditions. Germination percentages were improved by seed priming treatments for melon, and seedling uniformity was higher for seeds primed with Ba-2 than for seeds from the other treatments for watermelon. Seedling disease incidence of untreated seeds were
6.5% for watermelon and 16.0% for melon, and water-priming resulted in similar disease progress curves as the untreated control. Seed priming with Ba-2 and 2P24 significantly reduced seedling BFB incidence for both watermelon and melon. Evaluation with naturally infested watermelon seeds primed
with biocontrol strains indicated that 2P24 seed priming was more effective than Ba-2 ( P < 0.05) and 2P24 solid matrix priming, reducing the seedling disease incidence to 1.3%. Seed bio-priming has potential as an effective and eco-friendly approach for suppressing bacterial fruit
blotch seed-to-seedling transmission.
Implementasi Metode Analytical Hierarchy Process Untuk Prediksi Tingkat Kesuburan Tanah
Authors: Kartika Rina , Murnomo Agus , Adi Slamet Seno
Published: May 2023

Untuk menilai tingkat kesuburan tanah dinas pertanian masih menggunakan cara manual dengan menebak data hasil analisis tanah. Penelitian ini bertujuan mendapatkan sistem prediksi tingkat kesuburan tanah yang menerapkan metode analytical hierarchy process untuk memprediksi tingkat kesubutan tanah. Sistem prediksi tingkat kesuburan tanah ini dikembangkan dengan menggunan model waterfall  yang terdiri dari empat tahapan yaitu tahap analisis, tahap desain, tahap kode dan tahap pengujian. aplikasi untuk prediksi tingkat kesuburan tanah ini menggunakan metode AHP dengan menggunakan 7 kriteria. Pembuatan sistem prediksi tingkat kesuburan tanah ini menggunakan bahasa pemrograman PHP, framework yii dna database MySQL. Pengujian sistem menggunakan uji blackbox, pengujian aspek portability dan uji validasi kelayakan sistem yang dilakukan di Dinas Pertanian. Berdasarkan hasil pengujian dapat dinyatakan bahwa sistem prediksi tingkat kesuburan tanah dapat berjalan dengan baik sesuai dengan desain rancangan. Selain itu sistem prediksi tingkat kesuburan tanah dapat digunakan sebagai aplikasi untuk prediksi tingkat kesuburan tanah dengan beberapa penambahan.
Pengembangan Sistem Pendeteksi Gesture Angka pada Tangan secara Realtime Berbasis Android
Authors: Wulandari Pradipta Sekar Ayu Putri , Martono Kurniawan Teguh , Windasari Ike Pertiwi
Published: May 2023

The Image Processing technology growing very rapidly now days. Many research develop this system. Cause image processing system can help deaf communication. Communication is a very important basic in life. Based on health profile in 2005 from Indonesian Ministry of health, the Indonesian congenital deafness reached 214.100 people. The congenital deafness is a hearing loss since birth, which lack of nerve impulses in the ear to convert the mechanical energy of vibration into electrical energy.

With translator applications from sign languages to text, the deafness will be facilitated to interacting with other, despite the person canâ€™t understand sign languages. The pupose of Numbering Gesture Recognition Application exists is to be basic for the next research to built translator sign languages to text. Android platform choosen because this platform already spread and open source, so it will be easily to spread this application.
KHITAN WANITA PERSPEKTIF MEDIS DAN HUKUM ISLAM
Authors: Amin Ibnu
Published: May 2023

The term circumcision is not found in the Quran (both as ibarah al-nash and isyarat al-nash) moreover it means the verse to legalize female circumcision. The verse that is often quoted by some scholars to back up the practice of circumcision is the letter an-Nisa' verse 125, surah: 125 and Ali Imran, verse: 95, namely the recommendation to follow Ibrahim's millah, one of the millahs is circumcision. Medical research concluded that female circumcision is not a medical procedure because its implementation is not based on medical indications and has not proven its benefits to the health of the woman as stated in the consideration of Minister of Health Regulation No. 6/2014 concerning Revocation of Minister of Health Regulation 1636/2010 concerning Female Circumcision. Tracing the history that female circumcision departs from the legacy of the Arab tradition that has lasted a long time and when the arrival of Islam got the legitimacy of the Prophet that female circumcision is a "nobility". The method used in this research is library research with normative doctrinal analysis of female circumcision regulations in Indonesia with the Hadith of the Prophet Muhammad regarding female circumcision with several conclusions; First; The practice of female circumcision carried out by medical personnel in Indonesia only cuts off the tip of the clitoris and is not as dangerous as what other countries do or Western accusations that circumcision is an attempt to harass women, supported by Ali Akbar. when having sex, because the clitoris secrete a foul-smelling smegma and become a stimulant for the emergence of cancer of the testicles and cervix. Second; The legitimacy of the Prophet through the phrase "glory for women" if it is understood from a religious perspective, then circumcision is also a sunnah practice for women, from the second socio-cultural aspect when society views a circumcised woman as good (honorable), Islam allows it in accordance with the rules of ushul “al-‘adaah al-muhkamah” and in practice it must be carried out by medical and professional personnel.
A Model for Assessing the Functional Stability of Information Infrastructure Elements for Conditions of Exposure to Multiple Computer Attacks
Authors: Voevodin Vladislav
Published: May 2023

Information is given about a new approach to the application of methods of the theory of semi-Markov processes to solve the applied problem of assessing the functional stability of elements that make up the information infrastructure, functioning under the influence of multiple computer attacks. The task of assessing functional stability is reduced to the task of finding the survivability function of the element under study and determining its extreme values. The relevance of the study is substantiated. The rationale is based on the assumption that quantitative methods of studying the stability of technical systems, which operate on the theory of reliability, cannot always be used to assess survivability. The concepts of «stability» and «computer attack» are being clarified. Verbal and formal statements of research tasks are formulated. The novelty of the results obtained lies in the application of well-known methods to solve a practically significant problem in a new formulation, taking into account the limitations on the resource allocated to maintain the survivability of the element under study, provided that arbitrary distribution laws are adopted for the random times of the implementation of computer attacks and the recovery times of the functional element. Recommendations on the formation of initial data, the content of the enlarged stages of modeling and a test case to demonstrate the performance of the model are given. The results of the test simulation are presented in the form of graphs of the survivability function. The resulting application can be used in practice to construct a survivability function when implementing up to three computer attacks, as well as a tool for evaluating the reliability of analogous statistical models. The limitation is explained by a progressive increase in the dimension of the analytical model and a decrease in the possibility of its meaningful interpretation.
Atg1, a key regulator of autophagy, functions to promote MAPK activation and cell death upon calcium overload in fission yeast
Authors: Takasaki Teruaki , Utsumi Ryosuke , Shimada Erika , Bamba Asuka , Hagihara Kanako , Satoh Ryosuke , Sugiura Reiko
Published: May 2023

Autophagy promotes or inhibits cell death depending on the environment and cell type. Our previous findings suggested that Atg1 is genetically involved in the regulation of Pmk1 MAPK in fission yeast. Here, we showed that Δatg1 displays lower levels of Pmk1 MAPK phosphorylation than did the wild-type (WT) cells upon treatment with a 1,3-β-D-glucan synthase inhibitor micafungin or CaCl2, both of which activate Pmk1. Moreover, the overproduction of Atg1, but not that of the kinase inactivating Atg1D193A activates Pmk1 without any extracellular stimuli, suggesting that Atg1 may promote Pmk1 MAPK signaling activation. Notably, the overproduction of Atg1 induces a toxic effect on the growth of WT cells and the deletion of Pmk1 failed to suppress the cell death induced by Atg1, indicating that the Atg1-mediated cell death requires additional mechanism(s) other than Pmk1 activation. Moreover, atg1 gene deletion induces tolerance to micafungin and CaCl2, whereas pmk1 deletion induces severe sensitivities to these compounds. The Δatg1Δpmk1 double mutants display intermediate sensitivities to these compounds, showing that atg1 deletion partly suppressed growth inhibition induced by Δpmk1. Thus, Atg1 may act to promote cell death upon micafungin and CaCl2 stimuli regardless of Pmk1 MAPK activity. Since micafungin and CaCl2 are intracellular calcium inducers, our data reveal a novel role of the autophagy regulator Atg1 to induce cell death upon calcium overload independent of its role in Pmk1 MAPK activation.
Measurement of stresses and strains around a pushed-in model pile or cone penetrometer
Authors: Talesnick Mark , Omer Itamar
Published: May 2023

This paper describes the methods and outcomes of tests designed to simulate the penetration of a pushed-in model pile, or a field testing penetration element. The penetration element was a 25 mm dia. cylinder with a conical tip. The element was advanced into a sand profile subjected to vertical pressure under at-rest conditions. The unique aspect of the testing was the inclusion of in-soil measurement tools. Null soil pressure gauges were used to monitor radial pressures and in-soil linear strain devices were used to monitor radial strain at points within a measurement horizon as the penetration element was advanced into the profile. Testing revealed that radial pressures return to their ambient pre-penetration magnitudes once the element passes below a sensing horizon. In-soil radial strain measurements illustrated that the rapid drop in radial soil pressure coincides with a small, but consistent reversal in the increment of radial strain. As distance from the axis of penetration decreases this reversal is more significant. These observations have importance in considering the development of frictional resistance and axial capacity of pushed-in piles and at the same time have relevance to the analysis of cone penetration testing in the determination of rational material properties.
La Educación Inicial. Una visión desde los docentes en formación
Authors: Mármol Castillo Mónica Carolina , Conde Lorenzo Eddy , Vallejo Lecaro Carlos Enrique , Sailema Arteaga María Gabriela , Calderón Cedeño Emily Narcisa , Rengifo Barciona María Lorena , Reyes Ruiz María Inmaculada , Zúñiga Pacheco María del Pilar , Jurado Cusme Allyson , Yagual Barzola Narcisa Luciana , Ruiz Villanueva Julissa Yajaira , Salvador Espinoza María de los Ángeles , Bernal Tenorio Piedad Elena
Published: May 2023

Enmarcado en el área de la educación y la formación del personal docente, esta publicación refleja una serie de ideas desde la perspectiva de profesores y estudiantes que, de forma mancomunada, se han adentrado en el maravilloso mundo de la educación inicial. Está dirigida a educadores y docentes que tienen la gran responsabilidad de trabajar con niños y niñas de 0 a 6 años, en las instituciones que ofertan el nivel de Educación Inicial en el Ecuador. La metodología de la educación inicial constituye el eje transversal de este libro, en un abordaje sencillo, pero profundo, que va desde la epistemología de la educación inicial, pasando por experiencias de transición de la EI a la EGB, los proyectos de aula basados en la metodología juego-trabajo de los “rincones” de aprendizaje, hasta llegar a las metodologías activas a través de la gamificación, la flipped classroom o el ABP. En todo este recorrido se resalta que el juego propicia el espacio ideal para que los niños socialicen con los demás, recreen sus experiencias, refuercen valores, resuelvan conflictos, desarrollen competencias de liderazgo, etc., dejando atrás los conocimientos memorísticos y la repetición mecánica de los contenidos.
Library tissue handling, viral DNA extraction, and NGS sample preparation v2
Authors: Chuapoco Miguel
Published: May 2023

This protocol describes the procedure to isolate viral DNA from AAV-transfected tissue and prepare it for next-generation sequencing.
The properties of machine-tractor unit (MTU) regarding soil preparation with bed ridging
Authors: Ochotnikov Boris L. , Egorov Vasily N. , Stroganov Yury  N.
Published: May 2023

BACKGROUND:One of the main criteria for assessment of work performance is productivity. It depends on a number of indicators: towing resistance, optimal use of energy, used technical equipment, the adaptability of the equipment to the operation conditions, etc. Experimental studies are required in order to establish the patterns of influence of these indicators on work efficiency.
AIMS:Carrying out theoretical calculations and practical observations on the process of bed ridging for potatoes, assessment of the unit assembly for the technological process performing and the using of the unit.
METHODS:Field tests of a machine-tractor unit with subsequent result processing using the Microsoft Office applications.
RESULTS:Recommendations are given for practical use in the unit formation depending on velocity and operation width of the unit for various values of specific resistance.
CONCLUSIONS:The practical value of the study lies in the opportunity of using the proposed patterns for optimization the machine-tractor unit assembly according to operation conditions, selection of power unit, development of combined machines and units.
CASIE21-OBS: An Open-Access, OBS Controlled-Source Seismic Data Set for Investigating the Structure and Properties of the Cascadia Accretionary Wedge and the Downgoing Explorer-Juan de Fuca-Gorda Plate System
Authors: Canales Juan Pablo , Miller Nathaniel C. , Baldwin Wayne , Carbotte Suzanne M. , Han Shuoshuo , Boston Brian , Jian Hanchao , Collins John , Lizarralde Dan
Published: May 2023

Geological processes at subduction zones and their associated geohazards (e.g., megathrust earthquakes, submarine landslides, tsunamis, and arc volcanism) are, to a large extent, controlled by the structure, physical properties and fluid content of the subducting plate, the accreted sediments, and the overriding plate. In these settings, modern seismic modeling and imaging techniques based on controlled-source, multicomponent ocean-bottom seismometer (OBS) data are some of the best tools available for determining the subseafloor elastic properties, which can be linked to the aforementioned properties. Here, we present CASIE21-OBS, a controlled-source marine wide-angle OBS data set recently collected across the Cascadia convergent margin as part of the larger CAscadia Seismic Imaging Experiment 2021 (CASIE21). The main component of CASIE21 is a long-offset multichannel seismic (MCS) survey of the Cascadia margin conducted in June–July 2021 onboard R/V M.G. Langseth (cruise MGL2104) aiming to characterize the incoming plate, the plate interface geometry and properties, and the overlying sediment stratigraphy and physical properties. CASIE21-OBS was conducted during R/V M.G. Langseth cruise MGL2103 (May 2021) and R/V Oceanus cruise OC2106A (June–July 2021). It consisted of 63 short-period four-component OBSs deployed at a total 120 stations along 10 across-trench profiles extending from ∼50 km seaward of the deformation front to the continental shelf, and from offshore northern Vancouver Island to offshore southern Oregon. The OBSs recorded the airgun signals of the CASIE21-MCS survey as well as natural seismicity occurring during the deployment period (24 May 2021 19:00 UTC–9 July 2021 09:00 UTC). The OBS data are archived and available at the Incorporated Research Institutions for Seismology Data Management Center under network code YR_2021 for continuous time series (miniSEED) and identifier 21-008 for assembled data set (SEG-Y).
Индетерминация, изоморфизм, устойчивость: системная модель политического процесса в условиях цифровой трансформации
Authors: Кондратенко Константин
Published: May 2023

В статье представлена модель “индетерминированной системы” – абстракции, введенной для описания принципов организации публичного управления в условиях цифровой трансформации. В основу методологии статьи положен ряд системных подходов – кибернетический, структурно-функциональный, синергетический и др., а также ряд философских концептов, имеющих, по мнению автора, существенный эвристический потенциал для системных исследований. Модель “индетерминированных систем” основана не только на синтезе различных политических, философских и системных исследований, но и является некоторым теоретическим итогом работы автора в составе нескольких коллективов, проводивших в 2019-21 гг. как теоретические, так и эмпирические исследования в области цифровизации публичного управления. Базовое понятие статьи – “изоморфная индетерминированная система” – включает в себя основные структурные принципы публичного управления, связанные с отношением описываемой системы к другим системам. В статье также описываются принципы публичного управления, которым следуют индетерминированные системы, такие, как невидимость, усиление смысловых потоков, обеспечение связи и безразличие к событиям. Эти принципы, актуализированные в эпоху цифровой трансформации, с точки зрения автора являются не только ответом на рост влияния новых технологий в современном обществе, но и воплощают собою изначальные системные свойства бюрократии. Впрочем, данная модель не является “рациональной” – напротив, индетерминированные системы возникают, в первую очередь, как реакция на ожидания, совокупность которых в работе обозначена как топос. Детерминация и индетерминация сменяют друг друга в потоке управленческих циклов, стремясь к новой устойчивости. Устойчивость в работе трактуется не только как системный баланс, но и как сотрудничество в публичной политике как синергийное взаимодействие различных систем.
Decentralization, Systematization and Coordination in the Legislation Process in China: How does a Project Become a Law?
Authors: Deng Pan
Published: May 2023

This paper examines the allocation of the legislative authority of the People’s Republic of China between the central and local bodies. Given that the special administrative region system is the most characteristic, both in China and globally, a part is retained for the legislation of Hong Kong and Macao. Next, the paper analyzes the hierarchy of legal norms and the method to resolve conflicts between legal norms. Finally, the registration system is discussed to avoid contravention between the lower level law and the higher level, also, the possibility of cancellation is mentioned.
A study of prescription errors in South Indian City, Karnataka- An observational study
Authors: A P Ravinandan , Vishwas Hunsur Nagendra , Hosur Shashank S , K V Ashika , S Kavya
Published: May 2023

A prescription is a written order to provide instructions regarding patient medications by the physician. Prescription include directions for the pharmacist to dispense the medication, directions for the patient regarding administration of drugs. Patient demographics and prescriber details are the legal requirements of the prescription writing.

An observational study was conducted and data collection forms were used to collect the information from the patient. Confidentiality was maintained to secure the patient information, prescription details, throughout the study. All the prescriptions are analyzed for general details, medical components, and legal requirements. The data obtained were summed up and simple statistical analysis was performed to draw the results. All the prescriptions had general details mentioned in it.

The mentioning of demographic details in prescription were found to be 48.07%.

The clarity of the prescription related to legibility of handwriting was achieved in 92.24%.

Poly-therapy was observed in 73 prescriptions. Most of the prescriptions did not provided description on the direction on usage of medications.

Our study highlights the need to train prescribing doctors on writing rational prescriptions for quality improvement.
The Migration Problem in the Discourse of Right and Center-Right French Presidential Candidates
Authors: Kadyrmambetov Timur
Published: May 2023

The article examines the approaches of French presidential candidates from right-wing and center-right parties regarding the migration problem. All of the “right-wing” candidates, mentioned in this article, prioritize in their election programs the need to solve this problem by radical means. France is facing a continuing increase of the number of migrants from North African countries and, as a result, an increase of the number of Muslims in France. Such processes are causing resentment and tension in French society, which requires an immediate response from the authorities. Right-wing and sometimes ultra-right-wing candidates intend to solve this problem by harsh methods: limiting Muslim activities in the country and integrating them into society according to the “melting pot” principle, when all ethnic and religious minorities are “mixed”, losing their identity, especially their religion.
Approaches of Bennet-Lapid’s Government to Key Regional Security Threats to Israel’s Security
Authors: Tsarev Matvei
Published: May 2023

This analytical article examines the approaches of the Israeli government led by Naftali Bennett and Yair Lapid, who assumed power in Israel on June 13, 2021, to two key threats to Israeli security: a potential “nuclear deal” with Iran (Iran's nuclear program advancement) amid Iranian regime's support for Palestinian factions in the Gaza Strip and the problem of Palestinian-Israeli conflict settlement.
The author reviews Bennett’s and Lapid’s speeches and keynote articles from 2010 to 2021, when both leaders of the new government either had different posts in Benjamin Netanyahu’s governments, or were in opposition to the latter. Such an approach allowed the author to better understand the process of shaping Israel's strategy to the key threats to its security in the region. It is especially relevant in conditions of active development of knotty and order-forming crisis of international relations system, whose potential may affect subsystem of international relations in the Middle East.
The author concludes that regarding the Iranian nuclear problem, the most relevant strategy is deterrence by increasing risk (e. g., gradually destroying key elements of Iran's nuclear program), less likely is a pre-emptive escalation strategy (completely depriving Iran of the opportunity to threaten Israel before Tehran can implement its threats, or even declare them). This shows that Israel is focused on preserving the status quo. On the contrary, in the attempt to eliminate the problem of Iranian support for Palestinian factions in the Gaza Strip, Israel may pursue a strategy of escalatory domination, which signals its interest in changing the status quo. The Palestinian problem resolution will largely depend on the success of the Israeli government's political and economic actions toward both Palestinians living in the West Bank (those controlled by the Palestinian Authority in Ramallah and those living in Israeli-controlled territories) and the Arab population of the State of Israel.
The author suggests that it is possible to stop the Palestinians' Islamization process by creating a state mythologeme. Only the creation of a new ideology can become a multiplier of the state's extractive capacity, which for Arabs in the Israeli society would mean the legitimization of the central executive's right to govern them.
Al-Mas‘udi on the Important Personalities of the Arabic Olden Days. The Legendary Tradition about the Nizar’s Sons’ Partition of Fatherly Legacy
Authors: Mikulski Dimitri V.
Published: May 2023

Among the materials of Murudj al-Dhahab wa Ma‘adin al-Djawhar (“The Meadows of Gold and the Mines of Gems”) by al-Mas‘udi (10th century), dedicated to pre-Islamic Arabia, one notes the legendary tradition about the sons of Nizar, the for-father of the so called Northern Arabs: Unable to comprehend their father’s testimony, they turned for help to the wise king al-Af‘a b. al-Af‘a al-Djuhumi. On their way to the sage and during their stay at his lodging Nizar’s sons manifested unusual power for insight, earned the host’s favour and managed with the king’s help to understand their father’s will. It appeared that the testimony later influenced Nizar’s sons’ descendants’ way of life, as well as that of the members of major Arab tribes and tribe unions. The author displays the folklore origin of the story under study and also shows that, from the viewpoint of al-Mas‘udi, Nizar’s sons proved to be the masters of kiyafa, the specific Bedouin art of divination. Some tribes and clans of their descendants were later renowned for practicing that sort of skill. In addition to the study the author presents an academic translation of al-Mas‘udi’s version of the legendary tradition under question, as it is framed by an important cultural and historical context. Besides, the legend as presented by al-Mas‘udi possesses uncontestable literary qualities. For the sake of comparison, the academic translation of the version, presented by al-Tabari (839–923), is also delivered.
The Tribal Factor in the Peaceful Settlement of the Libyan Crisis
Authors: Luchenkov Ivan
Published: May 2023

The research is focused on the tribal issue as a leading factor of the Libyan political life in the context of the current negotiation process. Particular attention should be paid to the activities of the Warfalla Libyan Tribal Public Council and the Tuareg Council of Elders. These representative institutions have been calling for many years for the end of the turmoil, focusing on the traditional Islamic category of fitnah. It confirms that the Libyan crisis cannot be solved outside the country and that foreign interference is detrimental to the interests of the Libyan people. The category of 'asabiyyah or social solidarity is of paramount importance in this case. Nevertheless, it is not necessarily an attribute of a traditional nomadic or tribal community and is not based solely on kinship. However, this term often has a negative connotation, since it denotes a radical cohesion to a particular group, which forms a distinctive family-clan relationship. The Libyan tribes play a prominent role in maintaining political balance, combating terrorist groups, and maintaining the level of security by the support to political leaders who claims to consolidate Libya again.
This paper distances from the destabilizing manifestations of intertribal relations. Therefore, the purpose of this study is to define the role of the Arabic- and Berber-speaking tribes of the three constituent regions in Libya: Cyrenaica, Tripolitania, and Fezzan in de-escalating the conflict, aimed at restoring Libyan statehood and holding parliamentary and presidential elections.
O ENSINO DE IFRS EM INSTITUIÇÕES DE ENSINO SUPERIOR DE CIÊNCIAS CONTÁBEIS E ADMINISTRAÇÃO EM REGIÕES DO SUL E SUDESTE BRASILEIRO
Authors: Camargo Botazini Júnior Arnaldo
Published: May 2023

A Contabilidade brasileira, a partir das Leis 11.638/07 e 11.941/09, procurou adequar-se às normais internacionais de práticas e elaboração de demonstrações contábeis. Representou, um avanço para as Ciências Contábeis brasileiras, que, integraram-se a um contexto globalizado, como um desafio, dado às profundas modificações trazidas por tais normas e sua disseminação, adaptando profissionais atuantes e adequando os currículos no ensino superior, especificamente no caso das Ciências Contábeis, bem como daquelas áreas que lhes sejam afins, como a Administração. Assim, o presente estudo intenta apresentar a percepção dos discentes sobre a forma de como as normas internacionais estão sendo ensinadas nos cursos de Ciências Contábeis e Administração nas escolas superiores da base territorial em atuam seus autores. Esta pesquisa caracteriza-se como descritiva e quantitativa. Os dados foram coletados tendo como instrumento um questionário contendo doze perguntas fechadas, enviada via ferramenta google forms (por virtude da pandemia da Covid-19). A amostra da pesquisa foi composta por 58 entrevistados de 5 instituições de ensino superior diferentes. Após a conclusão da análise dos dados coletados, observa-se que a percepção dos discentes em relação ao conhecimento sobre IFRS ainda é considerado baixa, cabendo medidas que importem em sua maior disseminação.