bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-invasive intradialytic percutaneous perfusion monitoring: a view to the heart through the skin
Authors: Penny Jarrin D. , Hur Lisa , Salerno Fabio R. , Wong Dickson , Jan M. Hussain , McIntyre Christopher W.
Published: July 2023

Introduction

The life-sustaining treatment of hemodialysis (HD) induces recurrent and cumulative systemic circulatory stress resulting in cardiovascular injury. These recurrent insults compound preexisting cardiovascular sequalae leading to the development of myocardial injury and resulting in extremely high morbidity/mortality. This is largely a consequence of challenged microcirculatory flow within the myocardium (evidenced by detailed imaging-based studies). Currently, monitoring during HD is performed at the macrovascular level. Non-invasive monitoring of organ perfusion would allow the detection and therapeutic amelioration of this pathophysiological response to HD. Non-invasive percutaneous perfusion monitoring of the skin (using photoplethysmography—PPG) has been shown to be predictive of HD-induced myocardial stunning (a consequence of segmental ischemia). In this study, we extended these observations to include a dynamic assessment of skin perfusion during HD compared with directly measured myocardial perfusion during dialysis and cardiac contractile function.

Methods

We evaluated the intradialytic microcirculatory response in 12 patients receiving conventional HD treatments using continuous percutaneous perfusion monitoring throughout HD. Cardiac echocardiography was performed prior to the initiation of HD, and again at peak-HD stress, to assess the development of regional wall motion abnormalities (RWMAs). Myocardial perfusion imaging was obtained at the same timepoints (pre-HD and peak-HD stress), utilizing intravenous administered contrast and a computerized tomography (CT)-based method. Intradialytic changes in pulse strength (derived from PPG) were compared with the development of HD-induced RWMAs (indicative of myocardial stunning) and changes in myocardial perfusion.

Results

We found an association between the lowest pulse strength reduction (PPG) and the development of RWMAs (p = 0.03) and also with changes in global myocardial perfusion (CT) (p = 0.05). Ultrafiltration rate (mL/kg/hour) was a significant driver of HD-induced circulatory stress [(associated with the greatest pulse strength reduction (p = 0.01), a reduction in global myocardial perfusion (p = 0.001), and the development of RWMAs (p = 0.03)].

Discussion

Percutaneous perfusion monitoring using PPG is a useful method of assessing intradialytic hemodynamic stability and HD-induced circulatory stress. The information generated at the microcirculatory level of the skin is reflective of direct measures of myocardial perfusion and the development of HD-induced myocardial stunning. This approach for the detection and management of HD-induced cardiac injury warrants additional evaluation.
Manifold learning for fMRI time-varying functional connectivity
Authors: Gonzalez-Castillo Javier , Fernandez Isabel S. , Lam Ka Chun , Handwerker Daniel A. , Pereira Francisco , Bandettini Peter A.
Published: July 2023

Whole-brain functional connectivity (FC) measured with functional MRI (fMRI) evolves over time in meaningful ways at temporal scales going from years (e.g., development) to seconds [e.g., within-scan time-varying FC (tvFC)]. Yet, our ability to explore tvFC is severely constrained by its large dimensionality (several thousands). To overcome this difficulty, researchers often seek to generate low dimensional representations (e.g., 2D and 3D scatter plots) hoping those will retain important aspects of the data (e.g., relationships to behavior and disease progression). Limited prior empirical work suggests that manifold learning techniques (MLTs)—namely those seeking to infer a low dimensional non-linear surface (i.e., the manifold) where most of the data lies—are good candidates for accomplishing this task. Here we explore this possibility in detail. First, we discuss why one should expect tvFC data to lie on a low dimensional manifold. Second, we estimate what is the intrinsic dimension (ID; i.e., minimum number of latent dimensions) of tvFC data manifolds. Third, we describe the inner workings of three state-of-the-art MLTs: Laplacian Eigenmaps (LEs), T-distributed Stochastic Neighbor Embedding (T-SNE), and Uniform Manifold Approximation and Projection (UMAP). For each method, we empirically evaluate its ability to generate neuro-biologically meaningful representations of tvFC data, as well as their robustness against hyper-parameter selection. Our results show that tvFC data has an ID that ranges between 4 and 26, and that ID varies significantly between rest and task states. We also show how all three methods can effectively capture subject identity and task being performed: UMAP and T-SNE can capture these two levels of detail concurrently, but LE could only capture one at a time. We observed substantial variability in embedding quality across MLTs, and within-MLT as a function of hyper-parameter selection. To help alleviate this issue, we provide heuristics that can inform future studies. Finally, we also demonstrate the importance of feature normalization when combining data across subjects and the role that temporal autocorrelation plays in the application of MLTs to tvFC data. Overall, we conclude that while MLTs can be useful to generate summary views of labeled tvFC data, their application to unlabeled data such as resting-state remains challenging.
Neurofeedback therapy to improve cognitive function in patients with chronic post-stroke attention deficits: a within-subjects comparison
Authors: Kleih-Dahms Sonja C. , Botrel Loic
Published: July 2023

Introduction

We investigated a slow-cortical potential (SCP) neurofeedback therapy approach for rehabilitating chronic attention deficits after stroke. This study is the first attempt to train patients who survived stroke with SCP neurofeedback therapy.

Methods

We included N = 5 participants in a within-subjects follow-up design. We assessed neuropsychological and psychological performance at baseline (4 weeks before study onset), before study onset, after neurofeedback training, and at 3 months follow-up. Participants underwent 20 sessions of SCP neurofeedback training.

Results

Participants learned to regulate SCPs toward negativity, and we found indications for improved attention after the SCP neurofeedback therapy in some participants. Quality of life improved throughout the study according to engagement in activities of daily living. The self-reported motivation was related to mean SCP activation in two participants.

Discussion

We would like to bring attention to the potential of SCP neurofeedback therapy as a new rehabilitation method for treating post-stroke cognitive deficits. Studies with larger samples are warranted to corroborate the results.
Disentangling rodent behaviors to improve automated behavior recognition
Authors: Van Dam Elsbeth A. , Noldus Lucas P. J. J. , Van Gerven Marcel A. J.
Published: July 2023

Automated observation and analysis of behavior is important to facilitate progress in many fields of science. Recent developments in deep learning have enabled progress in object detection and tracking, but rodent behavior recognition struggles to exceed 75–80% accuracy for ethologically relevant behaviors. We investigate the main reasons why and distinguish three aspects of behavior dynamics that are difficult to automate. We isolate these aspects in an artificial dataset and reproduce effects with the state-of-the-art behavior recognition models. Having an endless amount of labeled training data with minimal input noise and representative dynamics will enable research to optimize behavior recognition architectures and get closer to human-like recognition performance for behaviors with challenging dynamics.
Balance beam crossing times are slower after noise exposure in rats
Authors: Bartikofsky Dylan , Hertz Mikayla Jade , Bauer David S. , Altschuler Richard , King W. Michael , Stewart Courtney Elaine
Published: July 2023

Introduction

The vestibular system integrates signals related to vision, head position, gravity, motion, and body position to provide stability during motion through the environment. Disruption in any of these systems can reduce agility and lead to changes in ability to safely navigate one’s environment. Causes of vestibular decline are diverse; however, excessive noise exposure can lead to otolith organ dysfunction. Specifically, 120 decibel (dB) sound pressure level (SPL) 1.5 kHz-centered 3-octave band noise (1.5 kHz 3OBN) causes peripheral vestibular dysfunction in rats, measured by vestibular short-latency evoked potential (VsEP) and reduced calretinin-immunolabeling of calyx-only afferent terminals in the striolar region of the saccule. The present study examined the functional impact of this noise exposure condition, examining changes in motor performance after noise exposure with a balance beam crossing task.

Methods

Balance beam crossing time in rats was assessed for 19 weeks before and 5 weeks after noise exposure. Balance beam crossings were scored to assess proficiency in the task. When animals were proficient, they received a single exposure to 120 dB SPL 3-octave band noise.

Results

During the initial training phase slower crossing times and higher scores, including multiple failures were observed. This was followed by a period of significant improvement leading to proficiency, characterized by fast and stable crossing times and consistently low scores. After noise exposure, crossing times were significantly elevated from baseline for 4-weeks. A total of 5 weeks after noise exposure, crossing times improved, and though still trending higher than baseline, they were no longer significantly different from baseline.

Discussion

These findings show that the noise-induced peripheral vestibular changes we previously observed at cellular and electro-physiological levels also have an impact at a functional level. It has been previously shown that imbalance is associated with slower walking speed in older adults and aged rats. These findings in noise-exposed rats may have implications for people who experience noisy environments and for seniors with a history of noise exposure who also experience balance disorders and may be at increased fall risk.
Breast-conserving surgery versus mastectomy for treatment of breast cancer after neoadjuvant chemotherapy
Authors: Song Yu-Chun , Huang Zhou , Fang Hui , Tang Yu , Jing Hao , Song Yong-Wen , Jin Jing , Liu Yue-Ping , Chen Bo , Tang Yuan , Qi Shu-Nan , Lu Ning-Ning , Li Ning , Li Ye-Xiong , Wang Shu-Lian
Published: July 2023

Background

To compare recurrence and survival outcomes between breast-conserving surgery (BCS) and mastectomy after neoadjuvant chemotherapy (NACT).

Methods

The data of 730 patients who underwent NACT between 2000 and 2014 were retrospectively reviewed. A total of 104 (14.2%) patients received BCS and 626 (85.8%) received mastectomy. Locoregional recurrence (LRR), distant metastases (DM), disease-free survival (DFS), breast cancer–specific survival (BCSS), and overall survival (OS) were analyzed using the Kaplan–Meier method. The impact of BCS versus mastectomy on outcomes was assessed by multivariate Cox models. Inverse probability of treatment weighting (IPTW) was used to balance covariates between the two groups.

Results

The median follow-up of BCS and mastectomy groups were 86.5 and 87.4 months, respectively. There were significant differences in distribution of most baseline characteristics between two groups. Compared with those who underwent mastectomy, the patients with BCS had similar 5-year LRR, DM, and DFS rates, but had significantly higher 5-year BCSS (98.9% vs. 90.4%, P = 0.005) and OS (98.9% vs. 90.1%, P = 0.003) rates. Multivariate analysis also showed that BCS significantly improved BCSS (HR = 0.27, 95% CI: 0.08-0.85, P = 0.025) and OS (HR = 0.25, 95% CI: 0.08-0.79, P = 0.018). After IPTW adjustment, the LRR, DM, DFS, BCSS and OS between two groups had no significant differences.

Conclusions

The recurrence and survival outcomes are comparable with BCS and mastectomy. Thus, BCS is a safe treatment option for selected breast cancer patients after NACT.
Identification of high-risk patients for referral through machine learning assisting the decision making to manage minor ailments in community pharmacies
Authors: Amador-Fernández Noelia , Benrimoj Shalom I. , García-Cárdenas Victoria , Gastelurrutia Miguel Ángel , Graham Emma L. , Palomo-Llinares Rubén , Sánchez-Tormo Julia , Baixauli Fernández Vicente J. , Pérez Hoyos Elena , Plaza Zamora Javier , Colomer Molina Vicente , Fuertes González Ricardo , García Agudo Óscar , Martínez-Martínez Fernando
Published: July 2023

Background: Data analysis techniques such as machine learning have been used for assisting in triage and the diagnosis of health problems. Nevertheless, it has not been used yet to assist community pharmacists with services such as the Minor Ailment Services These services have been implemented to reduce the burden of primary care consultations in general medical practitioners (GPs) and to allow a better utilization of community pharmacists’ skills. However, there is a need to refer high-risk patients to GPs.

Aim: To develop a predictive model for high-risk patients that need referral assisting community pharmacists’ triage through a minor ailment service.

Method: An ongoing pragmatic type 3 effectiveness-implementation hybrid study was undertaken at a national level in Spanish community pharmacies since October 2020. Pharmacists recruited patients presenting with minor ailments and followed them 10 days after the consultation. The main outcome measured was appropriate medical referral (in accordance with previously co-designed protocols). Nine machine learning models were tested (three statistical, three black box and three tree models) to assist pharmacists in the detection of high-risk individuals in need of referral.

Results: Over 14′000 patients were included in the study. Most patients were female (68.1%). With no previous treatment for the specific minor ailment (68.0%) presented. A percentage of patients had referral criteria (13.8%) however, not all of these patients were referred by the pharmacist to the GP (8.5%). The pharmacists were using their clinical expertise not to refer these patients. The primary prediction model was the radial support vector machine (RSVM) with an accuracy of 0.934 (CI95 = [0.926,0.942]), Cohen’s kappa of 0.630, recall equal to 0.975 and an area under the curve of 0.897. Twenty variables (out of 61 evaluated) were included in the model. radial support vector machine could predict 95.2% of the true negatives and 74.8% of the true positives. When evaluating the performance for the 25 patient’s profiles most frequent in the study, the model was considered appropriate for 56% of them.

Conclusion: A RSVM model was obtained to assist in the differentiation of patients that can be managed in community pharmacy from those who are at risk and should be evaluated by GPs. This tool potentially increases patients’ safety by increasing pharmacists’ ability to differentiate minor ailments from other medical conditions.
A large arteriovenous fistula steals a considerable part of systemic blood flow during veno-arterial extracorporeal circulation support in a porcine model
Authors: Valerianova A. , Mlcek M. , Kittnar O. , Grus T. , Tejkl L. , Lejsek V. , Malik J.
Published: July 2023

Background: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is one of the most frequently used mechanical circulatory support devices. Distribution of extracorporeal membrane oxygenation flow depends (similarly as the cardiac output distribution) on regional vascular resistance. Arteriovenous fistulas (AVFs), used frequently as hemodialysis access, represent a low-resistant circuit which steals part of the systemic perfusion. We tested the hypothesis that the presence of a large Arteriovenous fistulas significantly changes organ perfusion during a partial and a full Veno-arterial extracorporeal membrane oxygenation support.

Methods: The protocol was performed on domestic female pigs held under general anesthesia. Cannulas for Veno-arterial extracorporeal membrane oxygenation were inserted into femoral artery and vein. The Arteriovenous fistulas was created using another two high-diameter extracorporeal membrane oxygenation cannulas inserted in the contralateral femoral artery and vein. Catheters, flow probes, flow wires and other sensors were placed for continuous monitoring of haemodynamics and organ perfusion. A stepwise increase in extracorporeal membrane oxygenation flow was considered under beating heart and ventricular fibrillation (VF) with closed and opened Arteriovenous fistulas.

Results: Opening of a large Arteriovenous fistulas (blood flow ranging from 1.1 to 2.2 L/min) resulted in decrease of effective systemic blood flow by 17%–30% (p < 0.01 for all steps). This led to a significant decrease of carotid artery flow (ranging from 13% to 25% after Arteriovenous fistulas opening) following VF and under partial extracorporeal membrane oxygenation support. Cerebral tissue oxygenation measured by near infrared spectroscopy also decreased significantly in all steps. These changes occurred even with maintained perfusion pressure. Changes in coronary artery flow were driven by changes in the native cardiac output.

Conclusion: A large arteriovenous fistula can completely counteract Veno-arterial extracorporeal membrane oxygenation support unless maximal extracorporeal membrane oxygenation flow is applied. Cerebral blood flow and oxygenation are mainly compromised by the effect of the Arteriovenous fistulas. These effects could influence brain function in patients with Arteriovenous fistulas on Veno-arterial extracorporeal membrane oxygenation.
Application of the steady-state intestinal perfusion system in measuring intestinal fluid absorption and bicarbonate secretion in vivo
Authors: Fan Wenjuan , Tan Qinghai
Published: July 2023

Background: The steady-state intestinal perfusion system represents a tool used in measuring intestinal fluid absorption and bicarbonate secretion in vivo; however, detailed procedures and parameters were not elucidated fully.

Aim: We focused on the methods of the steady-state intestinal perfusion system comprehensively including the blood pressure, hematocrit, blood gas, and heart rate of mouse.

Methods: Anesthetized, tracheally intubated, and artificially ventilated mice were used for this system. The blood pressure, hematocrit, blood gas, heart rate, and rate of fluid absorption and HCO3- secretion of the small intestine and colon at different time points were evaluated.

Results: Blood pressure, hematocrit, blood gas, and heart rate became stable at the 30 min time point after completion of surgery and could be maintained for 2 h. Rates of fluid absorption and bicarbonate secretion were also kept stable during the period of steady state of mice. Rates of fluid absorption and bicarbonate secretion were different among the jejunum, ileum, proximal, and mid-distal colon.

Conclusion: The steady-state intestinal perfusion system is a reliable system for measuring intestinal fluid absorption and bicarbonate secretion in vivo.
Biostimulant Capacity of an Enzymatic Extract From Rice Bran Against Ozone-Induced Damage in Capsicum annum
Authors: Macias-Benitez Sandra , Navarro-Torre Salvadora , Caballero Pablo , Martín Luis , Revilla Elisa , Castaño Angélica , Parrado Juan
Published: July 2023

Ozone is a destructive pollutant, damaging crops, and decreasing crop yield. Therefore, there is great interest in finding strategies to alleviate ozone-induced crop losses. In plants, ozone enters leaves through the stomata and is immediately degraded into reactive oxygen species (ROS), producing ROS stress in plants. ROS stress can be controlled by ROS-scavenging systems that include enzymatic or non-enzymatic mechanisms. Our research group has developed a product from rice bran, a by-product of rice milling which has bioactive molecules that act as an antioxidant compound. This product is a water-soluble rice bran enzymatic extract (RBEE) which preserves all the properties and improves the solubility of proteins and the antioxidant components of rice bran. In previous works, the beneficial properties of RBEE have been demonstrated in animals. However, to date, RBEE has not been used as a protective agent against oxidative damage in agricultural fields. The main goal of this study was to investigate the ability of RBEE to be used as a biostimulant by preventing oxidative damage in plants, after ozone exposure. To perform this investigation, pepper plants (Capsicum annuum) exposed to ozone were treated with RBEE. RBEE protected the ozone-induced damage, as revealed by net photosynthetic rate and the content of photosynthetic pigments. RBEE also decreased the induction of antioxidant enzyme activities in leaves (catalase, superoxide dismutase, and ascorbate peroxidase) due to ozone exposure. ROS generation is a common consequence of diverse cellular traumas that also activate the mitogen-activated protein kinase (MAPK) cascade. Thus, it is known that the ozone damages are triggered by the MAPK cascade. To examine the involvement of the MAPK cascade in the ozone damage CaMPK6-1, CaMPK6-2, and CaMKK5 genes were analyzed by qRT-PCR. The results showed the involvement of the MAPK pathway in both, not only in ozone damage but especially in its protection by RBEE. Taken together, these results support that RBEE protects plants against ozone exposure and its use as a new biostimulant could be proposed.
Physiological effects of combined NaCl and NaHCO3 stress on the seedlings of two maple species
Authors: Xu Bo , Cao Lina , Zhang Zhenxing , Li Xinyu , Zhao Xiangyu , Wang Xinyue , Wang Yining , Wu Bingchen , Zhou Weihua , Lin Chenlu , Gao Yufu , Rong Liping
Published: July 2023

Salt stress impacts growth and physiological processes in plants, and some plants exposed to salt stress will produce physiological mechanisms to adapt to the new environment. However, the effects of combined NaCl and NaHCO3 stress on the seedlings of Acer species are understudied. In this study, we designed an experiment to measure physiological characteristics by establishing a range of NaCl and NaHCO3 concentrations (0, 25, 50, 75, and 100 mmol L-1) to estimate the compound salt tolerance of Acer ginnala and Acer palmatum. When the concentrations of NaCl and NaHCO3 were 25 mmol L-1, the leaf water content, relative conductivity, malondialdehyde (MDA) content, proline content, soluble sugar content, and chlorophyll did not change (p > 0.05) in two maple seedlings. At concentrations greater than 50 mmol L-1, the relative conductivity and MDA content increased, proline and soluble sugars accumulated, and the potential activity of PS II (Fv/Fo), potential photochemical efficiency of PS II (Fv/Fm), PS II actual photochemical efficiency (Yield), and photosynthetic electron transfer efficiency (ETR) decreased (p < 0.05). The superoxide dismutase (SOD) and catalase (CAT) activities showed the same trend of first increasing and then decreasing (p < 0.05). The peroxidase (POD) activity increased only when concentrations of NaCl and NaHCO3 were 100 mmol L-1, while there was no statistical difference between the other treatments and the control. Therefore, the two maple seedlings adjusted their osmotic balance and alleviated oxidative stress by accumulating proline, soluble sugars and increasing CAT and SOD activities. Further analysis showed that both species are salt tolerant and the salt tolerance of Acer ginnala is better than that of Acer palmatum.
Summer pruning in Mediterranean vineyards: is climate change affecting its perception, modalities, and effects?
Authors: Poni Stefano , Frioni Tommaso , Gatti Matteo
Published: July 2023

Summer pruning encompasses a series of operations typically performed on the grapevine during the growing season. This review provides an update on the research conducted over the last 20 years on the modalities and strategies of main summer pruning operations, which include shoot positioning and thinning, shoot trimming, leaf removal, and cluster thinning, with a special focus on their adaptation to climate change occurring in Mediterranean areas. Three main novelties emerged from the survey. First, due to a common need to shelter clusters against overheating and sunburn-related damages, shoot thinning and leaf removal are practices that are now being applied in a much more cautious and conservative manner. Second, the meaning of summer pruning is evolving because operations are being used as precious tools to direct ripening toward a desired direction rather than being received passively. Third, some operations, such as leaf removal, have disclosed very high plasticity, which means that, depending on the timing and modalities of the intervention, yield can be either increased or decreased and ripening anticipated or postponed. In an era where economic and environmental sustainability have to find a good compromise, cluster thinning is increasingly being depicted as an extraordinary operation that should be left to occasional occurrences of overcropping. Moreover, summer pruning is a tool through which growers can, to an extent, exploit the potentialities offered by climate change. For instance, the crop-forcing technique, under the different configurations of single and double cropping within the same season, has been trialed promisingly in several regions and cultivars. The principle of forcing is to unlock the dormant bud during the first year by removing at least the young organs present on the shoot within a time window between the end of the flowering and pea-size stages. In particular, when it is applied in a double-cropping mode, the preliminary results related to Pinot noir, Grenache, Tempranillo, and Maturana tinta indicate that two harvests separated by 30–50 days can be obtained, with the latter having superior quality in terms of a lower level of pH and higher levels of acidity, anthocyanins, and phenolics.
Music as a window into real-world communication
Authors: Izen Sarah C. , Cassano-Coleman Riesa Y. , Piazza Elise A.
Published: July 2023

Communication has been studied extensively in the context of speech and language. While speech is tremendously effective at transferring ideas between people, music is another communicative mode that has a unique power to bring people together and transmit a rich tapestry of emotions, through joint music-making and listening in a variety of everyday contexts. Research has begun to examine the behavioral and neural correlates of the joint action required for successful musical interactions, but it has yet to fully account for the rich, dynamic, multimodal nature of musical communication. We review the current literature in this area and propose that naturalistic musical paradigms will open up new ways to study communication more broadly.
“To be, or not be… satisfied in NPOs”: a serial multiple mediation and clustering analysis of paid staff and volunteers' profiles
Authors: López-Cabrera Rocío , Medina Francisco J. , Euwema Martin , Arenas Alicia
Published: July 2023

Introduction

Non-profit organizations (NPOs) are a complex working context whose main characteristic resides in the dichotomy between paid staff and volunteers. Despite its benefits for goal achievement, this circumstance can be also a challenge, for both groups' interaction, for their comprehension of their own role and to HR management. The aim of this study was to explore factors that may contribute to promote job satisfaction among NPOs' members.

Methods

Combining two different data analyses, serial multiple mediation analyses and cluster analyses, first we analyze whether there are differences between paid staff and volunteers in perceived intrapersonal conflict and performance and its effect on job satisfaction, and second, we analyze whether there is an additional profiles distribution that reflects more adequately the reality of NPOs, despite the formal roles that coexist in these organizations (paid staff and volunteers).

Results

Results confirm that paid staff and volunteers differ on their perceived job satisfaction level, with volunteers being more satisfied. This relationship is serially mediated by role conflict, role ambiguity, and performance. Another characteristic of the NPOs is that the dichotomy between paid staff and volunteers does not capture well the reality of the labor relations between members of both groups and the organization. To explore this phenomenon, we perform a cluster analysis based on paid staff and volunteers' perceptions. Cluster analyses demonstrate the existence of three rather homogenous profiles.

Discussion

Additionally, practical implications for HR management in NPOs and future research lines to understand this organizational context dynamics are also discussed.
Spanish and cross-cultural validation of the mind excessively wandering scale
Authors: Morillas-Romero Alfonso , De la Torre-Luque Alejandro , Mowlem Florence D. , Asherson Philip
Published: July 2023

Introduction

Over the last decade, excessive spontaneous mind wandering (MW) has been consistently associated with emotional disorders. The main aims of the present study were (1) to re-examine the factor structure of the Mind Excessively Wandering Scale (MEWS); (2) to validate the Spanish version of the MEWS; and (3) to conduct a cross-cultural validation of the MEWS in Spanish and UK samples.

Methods

A forward/backward translation to Spanish was conducted. Data of 391 Spanish and 713 British non-clinical individuals were analysed.

Results

A revised 10-item version of the MEWS (MEWS-v2.0) demonstrated to be a valid instrument to assess MW. A 2-correlated factor structure properly captured the MEWS-v2.0 variance, accounting for two specific but interrelated dimensions (Uncontrolled thoughts and Mental Overactivity).

Discussion

The Spanish MEWS-v2.0 showed adequate internal consistency and construct validity, as well as appropriate convergent/divergent validity. Cross-cultural analyses showed that MEWS-v2.0 captured the same construct in both UK and Spanish samples. In conclusion, both Spanish and English MEWS-v2.0 demonstrated to be reliable measures to capture spontaneous MW phenomenon in non-clinical adult populations.
Job burnout among teachers handling English as a foreign language in China: review and prospects
Authors: Yu Qiangfu , Yu Xiaofeng
Published: July 2023

In recent years, job burnout of English as a foreign language (EFL) teachers in China has become prominent in the field of education and psychology, with the related research articles generally on the rise. Using the database of Web of Science (WOS) and the sub-database of Chinese Social Sciences Citation Index (CSSCI) in China National Knowledge Infrastructure (CNKI) database, this paper comprehensively reviews the current situation of research on job burnout of EFL teachers in China between 2020 and 2023, from the aspects of research methods, research focuses and research findings. The literature research results show that on the whole, the research on job burnout of EFL teachers in China is still in its infancy, and that the research level is still relatively low. Based on the systematic reviews of the collected studies, we can conclude that although there is no unanimous conclusion between demographic variables and job burnout severity of EFL teachers in China, we can intervene at both the teacher and school levels to alleviate job burnout of EFL teachers. This review paper analyzes some main problems existing in the current research, for example, lack of theoretical construction and guidance, too much concentration on some research topics, lack of diversified and interdisciplinary research methods, lack of longitudinal research, and potential directions for future research are also discussed in the paper.
A conceptual framework for culturally appropriate advocacy with racialised groups
Authors: Salla Anthony , Newbigging Karen , Joseph Doreen , Eneje Emachi
Published: July 2023

Independent mental health advocacy was introduced in England to protect and promote the rights of people detained under mental health legislation. However, shortcomings in access and delivery to racialised people, raising concerns about equity, were identified by a review of the Mental Health Act. The development of culturally appropriate advocacy was recommended. While the term culturally appropriate may be taken for granted it is poorly defined and limited efforts have conceptualized it in relation to advocacy. Ideally, advocacy operates as a liberatory practice to challenge epistemic injustice, which people experiencing poor mental health are at acute risk of. This is amplified for people from racialised communities through systemic racism. This paper argues that advocacy and culturally appropriate practices are especially relevant to racialised people. It clarifies the importance of culture, race and racism to the role of advocacy, and understanding advocacy through the conceptual lens of epistemic injustice. A central aim of the paper is to draw on and appraise cultural competency models to develop a conceptual framing of cultural appropriate advocacy to promote epistemic justice.
Mapping bedrock topography: a seismic refraction survey and landscape analysis in the Laramie Range, Wyoming
Authors: Uecker Rachel Kaitlyn , Flinchum Brady Adams , Holbrook W. Steven , Carr Bradley James
Published: July 2023

Physical, chemical, and biological processes create and maintain the critical zone (CZ). In weathered and crystalline rocks, these processes occur over 10–100 s of meters and transform bedrock into soil. The CZ provides pore space and flow paths for groundwater, supplies nutrients for ecosystems, and provides the foundation for life. Vegetation in the aboveground CZ depends on these components and actively mediates Earth system processes like evapotranspiration, nutrient and water cycling, and hill slope erosion. Therefore, the vertical and lateral extent of the CZ can provide insight into the important chemical and physical processes that link life on the surface with geology 10–100 s meters below. In this study, we present 3.9 km of seismic refraction data in a weathered and crystalline granite in the Laramie Range, Wyoming. The refraction data were collected to investigate two ridges with clear contrasts in vegetation and slope. Given the large contrasts in slope, aspect, and vegetation cover, we expected large differences in CZ structure. However, our results suggest no significant differences in large-scale (>10 s of m) CZ structure as a function of slope or aspect. Our data appears to suggest a relationship between LiDAR-derived canopy height and depth to fractured bedrock where the tallest trees are located over regions with the shallowest depth to fractured bedrock. After separating our data by the presence or lack of vegetation, higher P-wave velocities under vegetation is likely a result of higher saturation.
An open-source tool for improving on-farm yield forecasting systems
Authors: Tomasella Javier , Martins Minella A. , Shrestha Nirman
Published: July 2023

Introduction

The increased frequency of extreme climate events, many of them of rapid onset, observed in many world regions, demands the development of a crop forecasting system for hazard preparedness based on both intraseasonal and extended climate prediction. This paper presents a Fortran version of the Crop Productivity Model AquaCrop that assesses climate and soil fertility effects on yield gap, which is crucial in crop forecasting systems

Methods

Firstly, the Fortran version model - AQF outputs were compared to the latest version of AquaCrop v 6.1. The computational performance of both versions was then compared using a 100-year hypothetical experiment. Then, field experiments combining fertility and water stress on productivity were used to assess AQF model simulation. Finally, we demonstrated the applicability of this software in a crop operational forecast system.

Results

Results revealed that the Fortran version showed statistically similar results to the original version (r2 > 0.93 and RMSEn < 11%, except in one experiment) and better computational efficiency. Field data indicated that AQF simulations are in close agreement with observation.

Conclusion

AQF offers a version of the AquaCrop developed for time-consuming applications, such as crop forecast systems and climate change simulations over large areas and explores mitigation and adaptation actions in the face of adverse effects of future climate change.
Chromogenic culture media complements diagnostic cytology in the visual identification of pathogenic skin bacteria in dogs and cats
Authors: Avberšek Miha , Ihssen Julian , Faccio Greta , Spitz Urs , Cugmas Blaž
Published: July 2023

In dogs and cats, bacterial skin infections (pyoderma and otitis externa) are a common cause for visiting the veterinary clinic. The most frequent skin pathogens are Staphylococcus pseudintermedius, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, often requiring different therapeutic antibiotic protocols. Unfavorably, existing diagnostics based on cytology cannot reveal bacterial species but only bacterial shapes such as cocci or rods. This microscopic limitation could be overcome by clinical translation of affordable chromogenic media, which enable species identification based on bacterial colonies growing in different colors and sizes. In this study, we determined how well inexperienced general veterinary clinicians identified bacterial pathogens from the skin and ears on two commercial (Chromatic™ MH and Flexicult® Vet) and one custom-made Mueller Hinton agar-based chromogenic medium. For this purpose, four veterinarians evaluated 100 unique samples representing 10 bacterial species. On average, clinicians correctly identified between 72.1 and 86.3% of bacterial species. Colony colors developed quickly on the Chromatic™ MH medium, leading to the highest 81.6% identification accuracy after 24 h incubation. However, Flexicult® Vet exhibited the highest accuracy of 86.3% after prolonged 48 h incubation. Evaluators easily recognized bacteria displaying uniquely colored colonies like green-brown Pseudomonas aeruginosa, blue Enterococcus faecalis, orange-brown Proteus spp., and red Escherichia coli. Oppositely, staphylococci shared uncharacteristically pale pink colonies causing misidentifications among the genus, deteriorating overall accuracy by around 10 percentage points (from 90.9%). Another reason for identification errors was the evaluators’ inexperience, reflected in not recognizing colony size differences. For example, although Streptococcus canis exhibited the tiniest colonies, the species was frequently mistaken for other cocci. Finally, around 10% of errors were negligence-related slips due to unconsidered sample history. To conclude, the introduction of chromogenic media into veterinary clinics can significantly complement diagnostics in skin inflammations by identifying pathogen species in around 80% of cases. The extra information may help in therapeutic dilemmas on antibiotics and standard antimicrobial susceptibility testing. Additional personnel training and evaluation help by visuals, flowcharts, checklists, and, if necessary, microbiologists could further improve identification accuracy.
Evaluation of the effects of the recommended oral dose of diflubenzuron on bovine sperm and oocyte quality using CASA and OPU-IVEP
Authors: Xavier Marcelo Cunha , Martins Leticia Prates , Moura Rodrigo Martins , Morais Divino Fabio , Barbosa Joao Vitor Lima , Figueiredo Ricardo Alamino , Peixer Mauricio Antonio Silva , Andrade Rosangela Vieira de , Viana Joao Henrique Moreira
Published: July 2023

Introduction

The aim of this study was to evaluate potential effects of diflubenzuron on the production and quality of gametes, and on in vitro embryo production (IVEP) outcomes, in cattle.

Methods

Two experiments were performed, the first to evaluate effects on semen, and the second on cumulus-oocyte complexes (COC) and on IVEP. Nelore (Bos taurus indicus) bulls (n = 14) or heifers (n = 16) were allocated into control (CG) or treatment (DIF) groups. All groups received a mineral mix supplement added (DIF) or not (CG) with diflubenzuron (30 mg/head/day), during 8 weeks. Animals were weighed and blood samples were collected throughout the experimental period. Every other week, bulls were subjected to semen collection and heifers to transvaginal ultrasound-guided follicle aspiration sessions. Semen underwent physical and morphological evaluation, and samples were stored for further computer-assisted sperm analysis. The COC recovered were evaluated according to morphology and those classified as viable were sent to an IVEP laboratory.

Results

Diflubenzuron had no effect (P > 0.05) on average body weight or in any blood hematological or biochemical endpoints, regardless of gender. In experiment 1, there was no difference (P > 0.05) between DIF and CG groups for sperm concentration, morphology, or kinetics. In experiment 2, there was also no effect of diflubenzuron on the number of total, viable, or grade I oocytes, as well as on cleavage or blastocyst rates (P > 0.05).

Discussion

In summary, the oral administration of diflubenzuron, within the recommended dose, has no short-term negative effects on sperm production and quality or on oocyte yield and developmental potential in vitro, in cattle.
Providing “Free” Access to Dialysis and Transplant to the Disfranchised. A Sustainable Model for Low and Low Middle Income Countries (LMICs)
Authors: Zafar Mirza Naqi , Rizvi Syed Adibul Hasan
Published: July 2023

Pakistan is a low-middle income country where incidence of End Stage Kidney Disease (ESKD) is 100–150 per million population (pmp). Paucity and high costs of renal replacement therapy (RRT) renders the majority disfranchised, since the dialysis rate is 15 pmp and the transplant rate is 4–5 pmp. In view of this, our center started an integrated dialysis and transplant program where all treatment is provided “Free of Cost” to all patients, with lifelong follow-up and medications. The model is based on the concept of community-government partnership funded by both partners. The annual contribution in 2021 was $37.4 million. >1,500 patients were dialyzed daily, and 6–8 received transplants weekly. Of the 6,553 transplants performed between 1985–2021, 988 (15%) were children. Overall, the 1 and 5-year graft survival rate was 97% and 88%. The donor clinic has 3,786 donors in regular yearly follow-up for up to 30–35 years where ESKD prevalence is 0.29%. Access to dialysis was increased by establishing six satellite centers reducing patient time and travel costs. Cost reductions by dialyzer reuse and generic drugs resulted in an annual saving of $5.8 m. This sustainable model has overcome the inherent socio-economic, logistic, cultural, and gender biases in RRT in LMICs. It has provided RRT with equity to the disfranchised in Pakistan and can be replicated in other LMICs with community-government support.
Distributed Model Predictive Control and Coalitional Control Strategies—Comparative Performance Analysis Using an Eight-Tank Process Case Study
Authors: Maxim Anca , Pauca Ovidiu , Caruntu Constantin-Florin
Published: July 2023

Complex systems composed of multiple interconnected sub-systems need to be controlled with specialized control algorithms. In this paper, two classes of control algorithms suitable for such processes are presented. Firstly, two distributed model predictive control (DMPC) strategies with different formulations are described. Afterward, a coalitional control (CC) strategy is proposed, with two different communication topologies, i.e., a default decentralized topology and a distributed topology. All algorithms were tested on the same simulation setup consisting of eight water tanks. The simulation results show that the coalitional control methodology has a similar performance to the distributed algorithms. Moreover, due to its simplified formulation, the former can be easily tested on embedded systems with limited computation storage.
Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning
Authors: Bulgaru Valeria Cristina , Pertea Ana Maria , Grosu Iulian Alexandru , Anghel Andrei Cristian , Pistol Gina Cecilia , Marin Daniela Eliza , Dinischiotu Anca , Taranu Ionelia
Published: July 2023

Zearalenone (ZEN) is a mycotoxin produced by Fusarium fungi that contaminates food and feed, affecting both human and animal health. Among farm animals, the pig is a great consumer of grains and has a native sensitivity to mycotoxins. As the main route of contamination is oral, the intestine is the first defense barrier that plays an important role in the immune response being able to secrete effector molecules (cytokines). At the European level, there are no regulations regarding the amount of ZEN that can be present in the feed of piglets, only recommendations for piglets 0.100 mg ZEN/kg feed (100 ppb). In this study, the effects of ZEN in concentrations below (75 ppb) and above (290 ppb) EU recommendation on the level of some key markers involved in the oxidative and inflammatory response, as well as the mechanisms and signaling pathways through which ZEN could produce its toxicity, were monitored in the colon of weaned piglets. The exposure of the piglets to the lower concentration of ZEN (75 ppb) did not lead to changes in stress and inflammation markers or in the signaling pathways associated with these processes.
Design and Experiment of Row Cleaner with Staggered Disc Teeth for No-Till Planter
Authors: Li Xin , Zhang Yinping , He Haojie , Wang Bin , Zhou Hua , Geng Duanyang , Zhang Yuzi
Published: July 2023

In view of the large amount of wheat straw coverage and the difficulty with the high-speed working process used in traditional rotary tillage row cleaner. A row cleaner with staggered disc teeth for no-till planting was designed. It was determined that installation with a forward inclination α, horizontal declination β, and forward speed v0 of the machine were the main factors affecting the straw cleaning rate Y1 and working resistance Y2, and the range of values for structural parameters and motion parameters of the row cleaner were determined. Taking α, β, and v0 as the factors and Y1 and Y2 as the response indexes, using EDEM 2018 software to simulate the straw cleaning process under different parameters and determine the influence of each parameter on the straw cleaning performance. After performing a soil bin test, the results showed that there was no straw entanglement and blockage, and the passability was better than that of the traditional flat disc separated row cleaner. When α was 70°, β was 30°, v0 was 8 km/h, and the embedded depth h of the soil (straw) was 55 mm, the average straw cleaning rate was the highest, which was 90.59%. This study provides a new idea for the design of high-speed corn no-till planters in the Huang-Huai-Hai area of China.