bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding priorities and needs for child and adolescent mental health in Greece from multiple informants: an open resource dataset
Authors: Koumoula Anastasia , Marchionatti Lauro Estivalete , Karagiorga Vasiliki Eirini , Schafer Julia Luiza , Simioni André , Caye Arthur , Serdari Aspasia , Kotsis Konstantinos , Basta Maria , Athanasopoulou Lilian , Dafoulis Vaios , Tatsiopoulou Paraskevi , Zilikis Nikos , Vergouli Evangelia , Balikou Panagiota , Kapsimalli Efstathia , Mitropoulou Andromachi , Tzotzi Alexandra , Klavdianou Nikanthi , Zeleni Domna , Mitroulaki Sotiria , Botzaki Anna , Gerostergios Giorgos , Samiotakis Giorgos , Moschos Giorgos , Giannopoulou Ioanna , Papanikolaou Katerina , Angeli Katerina , Scarmeas Nikolaos , Emanuele Jill , Schuster Kenneth , Karyotaki Eirini , Kalikow Lily , Pronoiti Katerina , Merikangas Kathleen R. , Szatmari Peter , Cuijpers Pim , Georgiades Katholiki , Milham Michael P. , Corcoran Mimi , Burke Sarah , Koplewicz Harold , Salum Giovanni Abrahão
Published: April 2024

The Child and Adolescent Mental Health Initiative (CAMHI) aims to enhance mental health care capacity for children and adolescents across Greece. Considering the need for evidence-based policy, the program developed an open-resource dataset for researching the field within the country. A comprehensive, mixed-method, community-based research was conducted in 2022/2023 assessing the current state, needs, barriers, and opportunities according to multiple viewpoints. We surveyed geographically distributed samples of 1,756 caregivers, 1,201 children/adolescents, 404 schoolteachers, and 475 health professionals using validated instruments to assess mental health symptoms, mental health needs, literacy and stigma, service use and access, professional practices, training background, and training needs and preferences. Fourteen focus groups were conducted with informants from diverse populations (including underrepresented minorities) to reach an in-depth understanding of those topics. A dataset with quantitative and qualitative findings is now available for researchers, policymakers, and society [https://osf.io/crz6h/ and https://rpubs.com/camhi/sdashboard]. This resource offers valuable data for assessing the needs and priorities for child and adolescent mental health care in Greece. It is now freely available to consult, and is expected to inform upcoming research and evidence-based professional training. This initiative may inspire similar ones in other countries, informing methodological strategies for researching mental health needs.
Characterizing Natural Frequencies of the Hybrid III and NOCSAE Headforms
Authors: Dingelstedt Kristin J. , Rowson Steve
Published: April 2024

The vibrational characteristics of the Hybrid III and NOCSAE headforms are not well understood. It is hypothesized that they may perform differently in certain loading environments due to their structural differences; their frequency responses may differ depending on the impact characteristics. Short-duration impacts excite a wider range of headform frequencies than longer-duration (padded) impacts. While headforms generally perform similarly during padded head impacts where resonant frequencies are avoided, excitation of resonant frequencies during short-duration impacts can result in differences in kinematic measurements between headforms for the matched impacts. This study aimed to identify the natural frequencies of each headform through experimental modal analysis techniques. An impulse hammer was used to excite various locations on both the Hybrid III and NOCSAE headforms. The resulting frequency response functions were analyzed to determine the first natural frequencies. The average first natural frequency of the NOCSAE headform was 812 Hz. The Hybrid III headform did not exhibit any natural frequencies below 1000 Hz. Comparisons of our results with previous studies of the human head suggest that the NOCSAE headform’s vibrational response aligns more closely with that of the human head, as it exhibits lower natural frequencies. This insight is particularly relevant for assessing head injury risk in short-duration impact scenarios, where resonant frequencies can influence the injury outcome.
Juridification of Workplace Mistreatment: a Document Study of SALAR – The Governing Organization for Public Administration in Sweden
Authors: Matsson Anneli
Published: April 2024

SALAR, Sweden’s largest employer association, advises the public sector on how to build management rules and processes. How SALAR relates to work environment policy and routines regarding the handling of mistreatment at work is yet unexplored. This research looks into SALAR’s advice to public-sector management on how to handle mistreatment. The study’s goal is to identify policy recommendations for the development of public-sector policies. The empirical source for this study was the SALAR website. As a result, document analysis was chosen as the method. The concept of juridification has been used to describe how professional life has grown increasingly linked with legal thinking. It is utilized as a lens in this study to understand the advancement of workplace misconduct policy in Sweden’s public sector. According to the data, SALAR views workplace mistreatment as a transaction issue rather than a work environment issue. Furthermore, the policy provides an ambiguous definition of workplace mistreatment, strengthens an individual’s perspective on workplace mistreatment, and suggests bullying investigations as the only management. The conclusion is that SALAR’s recommendations have been clouded by the logic fallacy of the juridification process and dismiss workplace mistreatment as a work environment problem. The recommendations are insufficient for decision-makers to understand workplace mistreatment, thereby increasing the risk for employees exposed to mistreatment in Sweden’s public sector.
Machine learning-based pathomics signature of histology slides as a novel prognostic indicator in primary central nervous system lymphoma
Authors: Duan Ling , He Yongqi , Guo Wenhui , Du Yanru , Yin Shuo , Yang Shoubo , Dong Gehong , Li Wenbin , Chen Feng
Published: April 2024

Purpose

To develop and validate a pathomics signature for predicting the outcomes of Primary Central Nervous System Lymphoma (PCNSL).

Methods

In this study, 132 whole-slide images (WSIs) of 114 patients with PCNSL were enrolled. Quantitative features of hematoxylin and eosin (H&E) stained slides were extracted using CellProfiler. A pathomics signature was established and validated. Cox regression analysis, receiver operating characteristic (ROC) curves, Calibration, decision curve analysis (DCA), and net reclassification improvement (NRI) were performed to assess the significance and performance.

Results

In total, 802 features were extracted using a fully automated pipeline. Six machine-learning classifiers demonstrated high accuracy in distinguishing malignant neoplasms. The pathomics signature remained a significant factor of overall survival (OS) and progression-free survival (PFS) in the training cohort (OS: HR 7.423, p < 0.001; PFS: HR 2.143, p = 0.022) and independent validation cohort (OS: HR 4.204, p = 0.017; PFS: HR 3.243, p = 0.005). A significantly lower response rate to initial treatment was found in high Path-score group (19/35, 54.29%) as compared to patients in the low Path-score group (16/70, 22.86%; p < 0.001). The DCA and NRI analyses confirmed that the nomogram showed incremental performance compared with existing models. The ROC curve demonstrated a relatively sensitive and specific profile for the nomogram (1-, 2-, and 3-year AUC = 0.862, 0.932, and 0.927, respectively).

Conclusion

As a novel, non-invasive, and convenient approach, the newly developed pathomics signature is a powerful predictor of OS and PFS in PCNSL and might be a potential predictive indicator for therapeutic response.
Primary squamous cell carcinoma of the breast: a case report
Authors: Liu Xibo , Chen Jiahui , Hou Chuanling
Published: April 2024

Introduction

Squamous cell carcinoma (SCC) of the breast is a rare variant of invasive breast cancer that has been classified as metaplastic carcinoma. When a tumor is composed of spindle cells, diagnosis is challenging.

Case report

A 42-year-old woman with a large mass in the right breast underwent modified radical mastectomy. A pathological examination revealed a tumor with central necrosis in it. The tumor had a sarcomatoid growth pattern and the cells were spindle-shaped with severe atypicality. Immunohistochemical staining showed that P63, P53, vimentin, and CKpan were positive, whereas estrogen receptor and C-erbB-2 were negative. Ki-67 proliferation index was as high as 90%. Therefore, a diagnosis of SCC of the right breast was made. The patient received eight cycles of postoperative chemotherapy with paclitaxel and carboplatin, followed by seven cycles of radiotherapy. During follow-up, the patient also had a left thyroid tumor, and postoperative pathology suggested microinvasive follicular carcinoma. Since breast surgery, the patient has remained disease-free for more than four years.

Conclusion

SCC of the breast with spindle cell and sarcomatoid features is rare. The diagnosis of such tumors requires exclusion of tumors with similar histological morphologies.
New smart twisting active rotor (STAR): pretest predictions
Authors: van der Wall Berend G. , Lim Joon W. , Riemenschneider Johannes , Kalow Steffen , Wilke Gunther A. , Boyd D. Douglas , Bailly Joelle , Delrieux Yves , Cafarelli Italo , Tanabe Yasutada , Sugawara Hideaki , Jung Sung N. , Hong Seong H. , Kim Do-Hyung , Kang Hee J. , Barakos George , Steininger Rinaldo
Published: April 2024

A Mach-scaled model rotor with an active twist capability is in preparation for a wind tunnel test in the large low-speed facility of the German-Dutch wind tunnel (DNW) with international participation by the German Aerospace Center (DLR), US Army Combat Capabilities Development Command (DEVCOM) Aviation & Missile Center, National Aeronautics and Space Administration, French Aerospace Lab (ONERA), Korea Aerospace Research Institute, Konkuk University, Japan Aerospace Exploration Agency, Glasgow University, and DNW. To get the maximum benefit from the test and the most valuable data within the available test time, the tentative test matrix was covered by predictions of the partners, active twist benefits were evaluated, and support was provided to the test team to focus on the key operational conditions.
Mucormycosis: a rare forgotten but fatal disease—a case report and literature review
Authors: Matiku Subira Bhoke , Murenzi Gad , Shaban Idd , Msonge Augustine Muhiza , Kamafa Ajuna Enock , Kitua Daniel W. , Kimambo Asteria , Mwakigonja Amos Rodger , Massawe Enica Richard
Published: April 2024

Mucormycosis is a perilous fungal infection that primarily affects individuals with compromised immune systems. The escalating incidence of conditions such as diabetes, cancer and the use of immunosuppressive drugs renders more individuals susceptible to contracting this disease. This report delves into the case of a 45-year-old woman from Tanzania with diabetes who succumbed to rhino-cerebral mucormycosis. Despite aggressive treatment, which often involves disfiguring surgical debridement and administration of antifungal drugs, the mortality rate remains high. Additionally, we present a comprehensive literature review of the various clinical aspects of Mucormycosis, an uncommon yet fatal condition.
High-flow nasal oxygen in infants and children for early respiratory management of pneumonia-induced acute hypoxemic respiratory failure: the CENTURI randomized clinical trial
Authors: Kandasamy Sasidaran , Rameshkumar Ramachandran , Sangaralingam Thangavelu , Krishnamoorthy Nedunchelian , Shankar N. C. Gowri , Vijayakumar Vimalraj , Sridharan Balaji
Published: April 2024

Objective

To compare the effectiveness of early high-flow nasal cannula (HFNC) and low-flow oxygen support (LFOS) in children under 5 years with acute hypoxemic respiratory failure (AHRF) due to severe community-acquired pneumonia in low-middle-income countries.

Methods

An open-label randomized clinical trial enrolled children aged 2–59 months with AHRF due to severe community-acquired pneumonia and randomized into HFNC and LFOS. In the LFOS group, the patient received cold wall oxygen humidified by bubbling through sterile water administered through simple nasal prongs at a fixed flow rate of 2 L/min. In the HFNC group, the patient received humidified, heated (37 °C), high-flow oxygen at a flow rate assigned based on weight range, with a titratable oxygen fraction. The primary outcome was treatment failure in 72 h (escalating the respiratory support method using any modality other than primary intervention).

Results

Data was analyzed intention-to-treat (HFNC = 124; LFOS = 120). Median (IQR) age was 12 (6–20) and 11 (6–27) months, respectively. Treatment failure occurred in a significantly lower proportion in the HFNC group (7.3%, n = 9/124) as compared to the LFOS group (20%, n = 24/120) (relative risk = 0.36, 95% CI 0.18 to 0.75; p = 0.004; adjusted hazard ratio 0.34, 95% CI 0.16 to 0.73; p = 0.006). The intubation rate was significantly lower in the HFNC group (7.3%, n = 9/124 vs. 16.7%, n = 20/120; relative risk = 0.44, 95% CI 0.21 to 0.92, p = 0.023). There were no significant differences noted in other secondary outcomes. No mortality occurred.

Conclusion

High-flow nasal cannula oxygen therapy used as early respiratory support in children under 5 years with acute hypoxemic respiratory failure due to severe community-acquired pneumonia was associated with significantly lower treatment failure compared with standard low-flow oxygen support.

Trial registration

CTRI/2016/04/006788. Registered 01 April 2016, https://ctri.nic.in/Clinicaltrials/advsearch.php.
Public science and environmental sustainability: a national culture framework for innovation ecosystems en route to net zero
Authors: Cacciolatti Luca
Published: April 2024

Despite the proliferation of national environmental science worldwide, the erosion of environmental sustainability presents a problem for advanced economies with a substantial volume of scientific output. The worsening state of the natural environment presents a profound conundrum at the intersection of science and sustainability, characterised by conflicting pathways for the world’s nations. In this study, I confront this predicament by examining whether the influence of national culture moderates the transition of domestic scientific research into tangible CO2 emissions reduction. Drawing on a dataset spanning 30 nations renowned for their high scientific productivity over a 24-year period, I use a panel data model that incorporates lag time to analyse the nuanced impact of national cultures on sustainability. My findings reveal distinctive outcomes: those cultures characterised by high Power Distance (e.g., Eastern European) contribute to increased CO2 emissions via an industrial innovation pathway that prioritises economic growth, while those with high Individualism and high Uncertainty Avoidance (e.g., Western European) facilitate a reduction in CO2 emissions through the translation of scientific knowledge into public science that stimulates a societal innovation pathway and sustainability. In addition to these moderating effects, my investigation exposes that Gross Domestic Product (GDP) per capita exerts a direct positive influence on CO2 emissions, while an increase of GDP allocated to military expenditure (e.g., USA, China, Israel, South Korea) has detrimental effects on CO2 emissions, potentially hampering Net Zero aspirations. These findings hold significant implications for both theory and policymaking in the environmental arena.
Interrogating the Drunkards and Representing Drunkenness in the Qing Law
Authors: Guo Jackson Yue Bin
Published: April 2024

The consumption of shaojiu or distilled liquor played a significant role in Qing legal culture and contributed to a rise in alcohol-related crimes. Qing officials’ attitudes towards intoxication not only influenced their judgments on many cases, but also reflected important trends of popular beliefs, notions, and practices that constituted shared knowledge and feelings between ordinary people and judges. This paper examines the transformation of Qing judicial practices and concerns regarding alcohol intoxication and crimes, arguing that specific cultural value and ideas that underpinned the public configuration of drinking behaviour during the Qing period contributed to a social pathology around intoxication. Due to the lack of a consistent interpretation of the effects of alcohol on the mind, early Qing officials tended to be lenient towards intoxicated offenders. However, mid-Qing law-makers and rulers recognized the serious administrative concerns associated with heavy drinking and began to conceptualize it as a serious social problem.
Deployment of digital technologies in African cities: emerging issues and policy recommendations for local governments
Authors: Jieutsa Leandry , Gbaguidi Irina , Nadifi Wijdane , Koseki Shin
Published: April 2024

The deployment of digital technologies in African cities, beyond improving service delivery, raises issues of digital inclusion, digital rights, and increasing spatial and social inequalities. As part of the African Cities Lab Summit 2023, we conducted a workshop with 20 multidisciplinary participants to explore issues related to the deployment of digital technologies in African cities. This research is a policy paper that addresses these issues and provides policy recommendations for local governments. It emphasizes the importance of inclusive digital infrastructure, regulations safeguarding vulnerable sectors, and governance ensuring citizens’ rights in the digital transformation. Focusing on transparency, equity, and collaboration with communities, local governments play a vital role in fostering inclusive digital transformation, essential for equitable and rights-centric smart cities in Africa.
Factors that promote the repulsion effect in preferential choice
Authors: Banerjee Pronobesh , Hayes William M. , Chatterjee Promothesh , Masters Tamara , Mishra Sanjay , Wedell Douglas H.
Published: April 2024

Inclusion of a decoy alternative dominated by a target option, but not its competitor, typically leads to increased choice for the target over the competitor, known as the attraction effect. However, the reverse sometimes occurs, known as the repulsion effect. This research tested factors that moderate the repulsion effect in preferential choice scenarios with numerical attributes. Experiment 1 used a between-subjects design with a small set of consumer products and demonstrated robust repulsion effects that did not depend on the relative similarity of the decoy and target. Experiments 2 and 4 used a more powerful within-subjects design along with an expanded set of products and showed that repulsion effects were generally enhanced when the decoy and target had more similar attributes; however, the moderating effect of decoy–target similarity appeared to be fragile and sensitive to stimulus presentation factors. These findings provided mixed support for the hypothesis that the target is tainted by its proximity to the decoy. Experiments 3 and 5 tested whether the extremity of values on the attribute favoring the target moderates the repulsion effect. The results demonstrated that repulsion is more likely when all the alternatives have extremely high values on the target’s better attribute. Extremity of attribute values on the dimension favoring the target may result in a categorical assessment along that dimension and shift focus to the attribute favoring the competitor as one way to foster the repulsion effect.
Three-dimensional transition of the flow past an elastically mounted circular cylinder
Authors: Mishra Rahul , Bhardwaj Rajneesh , Thompson Mark C.
Published: April 2024

Floquet stability analysis and direct simulations of a circular cylinder undergoing vortex-induced vibration (VIV) are presented. Simulation predictions are examined for the reduced velocity range over which there is a strong and periodic resonant response:

$U_r \in [4.0, 8.0]$

, focusing on a mass ratio of

$m^* = 2.546$

matching a number of previous investigations. Over most of this range, the dominant wake modes present are analogous to modes A, B and QP (quasi-periodic) observed in a stationary circular cylinder wake. However, at

$U_r = 4.5$

, the dominant modes are B, QP and a subharmonic mode (SH), whereas at

$U_r = 4.0$

, the two-dimensional base state switches to a

$P+S$

wake. The critical Reynolds number for two- to three-dimensional transition is observed to decrease with an increase of

$U_r$

, in line with a decreasing response amplitude. Over this range, the minimum

${\textit {Re}}$

for which the wake remains two-dimensional is 202, which occurs at

$U_r = 7.5$

, but this increases to

${\textit {Re}}_{cr} = 300$

at

$U_r = 4.5$

, noting the critical Reynolds number for a stationary circular cylinder is

${\textit {Re}}_{cr}=189$

. The corresponding critical spanwise wavelengths for

$U_r = 4.5$

and 8 are

$1.4D$

(mode B) and

$4.0D$

(mode A), respectively. Simulations indicate that even at

$Re=300$

, flow three-dimensionality increases the amplitude of the lower branch considerably. The investigation establishes the role of oscillation amplitude and reduced velocity in three-dimensional transition for elastically mounted systems.
Evaporation of acoustically levitated bicomponent droplets: mass and heat transfer characteristics
Authors: Wakata Yuki , Chao Xing , Sun Chao , Diddens Christian
Published: April 2024

Evaporation of multicomponent droplets is important, albeit complex, in a wide range of applications, and requires a careful investigation. We investigate experimentally and numerically the evaporation characteristics of spherical, ethanol–water droplets with different initial concentration ratios in the acoustic levitation field. Imaging techniques and infrared thermometry are used for acquiring volume and surface temperature variations of droplets, reflecting their mass and heat transfer characteristics. Numerical simulations are conducted using modified parameters based on a theoretical model to consider the effect of the acoustic field. The calculation results show good agreement with the experimental data. The concentration and temperature distribution within the droplet is further investigated based on the numerical results.
Universal relative scaling of longitudinal structure functions in shear-dominated turbulence
Authors: Maryada K.R. , Armfield S.W. , MacDonald M. , Dhopade P. , Norris S.E.
Published: April 2024

Shear significantly influences turbulence in the energy-containing range of shear-dominated flows, and the longitudinal structure functions do not have a universal form as they do in homogeneous isotropic turbulence. Despite this, the relative scaling of structure functions exhibits universal sub-Gaussian behaviour in shear-dominated flows, in particular for turbulent boundary layers, channels and Taylor–Couette flows. Our investigation of a turbulent vertical buoyancy layer at

$Pr = 0.71$

using direct numerical simulation shows this universality even in moderate-Reynolds-number buoyancy-driven but shear-dominated boundary layers. It is demonstrated that the universality is related to the energy density of the eddies, which attains a hierarchical equilibrium in the energy-containing range of shear-dominated turbulence. We conjecture that the universal sub-Gaussian behaviour of the energy density of the energy-containing range, which was considered to be non-trivial in prior studies, is related to the universal anomalous scaling exponents of the inertial subrange turbulence. Based on this conjecture, we propose a hypothesis that relates large-scale eddies and the intermittent dissipation field in shear-dominated turbulence, highlighting a relationship between large and small scales. A phenomenological model is also developed to predict the scaling, which is verified using data from a turbulent boundary layer, half-channel and vertical buoyancy layer at friction Reynolds numbers spanning four orders of magnitude. Excellent agreement is observed.
Lagrangian and Eulerian perspectives of turbulent transport mechanisms in a lateral cavity
Authors: Barros Magdalena , Escauriaza Cristián
Published: April 2024

The dynamics of turbulent flows past lateral cavities is relevant for multiple environmental applications. In rivers and coastal environments, these lateral recirculating regions constitute surface storage zones, where large-scale turbulent coherent structures control the transport and fate of contaminants. Mass transport in these flows is typically represented by one-dimensional first-order equations that predict the evolution of the spatially integrated concentration between the cavity and the main channel. These models, however, cannot represent the long-term evolution of the concentration or incorporate memory effects induced by turbulence. In this investigation, we carry out large-eddy simulations (LES) of the open-channel flow with a lateral square cavity of Mignot et al. (Phys. Fluids, vol. 28, issue 4, 2016, 045104). The model is coupled with an advection–diffusion equation and a Lagrangian particle model to investigate the transport mechanisms in the cavity and across the interface. From the simulations we provide quantitative comparisons of the physical processes from both perspectives, and investigate the effects of turbulent coherent structures on residence times and trajectories from finite-time Lyapunov exponents. From the Lagrangian results, we identify general spatial distributions of time scales in the cavity associated with the dynamics of coherent structures, providing new insights into the mechanisms that drive the global transport. We also show that an upscaled model informed by LES and based on a fractional derivative captures the evolution of concentration, and the exchange between the cavity and the main channel, providing accurate predictions of mass transport and reproducing the temporal dependence observed at larger scales.
Re-Territorializing the Neolithic: Architecture and Rhythms in Early Sedentary Societies of the Near East
Authors: Hadad Rémi
Published: April 2024

Revivals of public interest in the Neolithic Near East have generally coincided with the emergence of powerful imagery, such as the discovery of Çatalhöyük’s striking wall paintings in the 1960s. Now, sixty years later, the sculptures of Göbekli Tepe are ensuring the period’s widespread appeal. The capacity of these well-preserved buildings to carry such imagery until today has made them, in turn, an image of the supposed achievements of Neolithic sedentism. But the popularity of these images depends on their decontextualization. This modernist notion that permanent architecture represents the conquest of spatial forms over time is in contradiction with the early Neolithic experience of settled life, which had more to do with the unstable duration of places than with an emancipation from motion. This essay explores the Neolithic preference for earth architecture over more stable construction materials such as stone, its influence on visual culture, and how it contributed to building new living relations to the inhabited landscape. Instead of the sense of fixity and completeness that we, moderns, desperately seek in plans, reconstructions, and monumentality, it is the very transience, repetitiveness, and cumulativeness of earth that determined the transformations of the archaeological record. In other words, rhythms are key to understanding Neolithic sedentism in ways that differ wildly from the static images we have substituted for it.
A Hungarian Old China Hand and the End of Empire: Loyalty Struggles in Interwar Shanghai's Migrant Community
Authors: Mervay Mátyás
Published: April 2024

This article explores the consequences of the Austro-Hungarian Empire's end through the tumultuous biography of a philanthropic entrepreneur and quasi-consul community leader known today for assisting thousands of Jewish refugees during World War II. Focusing on Paul Komor (1886–1973) and the migrant community of Shanghai Hungarians, the article contends that postimperial diasporas preserved a piece of empire in their commitment to Jewish emancipation, imperialist nationalism, multiple loyalties, and political nostalgia. It also argues that diasporic networks and charitable actions communicated political and national loyalties while creating and defining the boundaries of the community. Presenting original research involving sources in multiple languages from China, Hungary, the U.S., the U.K., and the Netherlands, the article traces the fortunes of a Jewish Hungarian family in colonial Shanghai, shows the limits of its son's charity-rooted advancement in community leadership, sheds light on the seemingly contradictory political ideas of a postimperial expatriate to explain his complicated relationship with his kinstate, and analyzes the institutionalization of communal charity and the competing prerequisite definitions of postimperial national belonging.
Benchmarking online food delivery applications against menu labelling laws: a cross-sectional observational analysis
Authors: Cassano Sophia , Jia Anna , Gibson Alice A , Partridge Stephanie R , Chan Virginia , Farrell Penny , Phongsavan Philayrath , Allman-Farinelli Margaret , Jia Si Si
Published: April 2024

Objective:

It is unknown how well menu labelling schemes that enforce the display of kilojoule (kJ) labelling at point-of-sale have been implemented on online food delivery (OFD) services in Australia. This study aimed to examine the prevalence of kJ labelling on the online menus of large food outlets with more than twenty locations in the state or fifty locations nationally. A secondary aim was to evaluate the nutritional quality of menu items on OFD from mid-sized outlets that have fewer locations than what is specified in the current scheme.

Design:

Cross-sectional analysis. Prevalence of kJ labelling by large food outlets on OFD from August to September 2022 was examined. Proportion of discretionary (‘junk food’) items on menus from mid-sized outlets was assessed.

Setting:

Forty-three unique large food outlets on company (e.g. MyMacca’s) and third party OFD (Uber Eats, Menulog, Deliveroo) within Sydney, Australia. Ninety-two mid-sized food outlets were analysed.

Participants:

N/A.

Results:

On company OFD apps, 35 % (7/23) had complete kJ labelling for each menu item. In comparison, only 4·8 % (2/42), 5·3 % (2/38) and 3·6 % (1/28) of large outlets on Uber Eats, Menulog and Deliveroo had complete kJ labelling at all locations, respectively. Over three-quarters, 76·3 % (345/452) of menu items from mid-sized outlets were classified as discretionary.

Conclusions:

Kilojoule labelling was absent or incomplete on a high proportion of online menus. Mid-sized outlets have abundant discretionary choices and yet escape criteria for mandatory menu labelling laws. Our findings show the need to further monitor the implementation of nutrition policies on OFD.
Agendas of Reform: Continuity and Change in Australia’s National Disability Insurance Scheme (NDIS)
Authors: Hummell Eloise , Borg Samantha J. , Foster Michele , Burns Kylie , Harris Rimmer Susan
Published: April 2024

This article used text mining processes to map continuity and change in policy principles of the National Disability Insurance Scheme (NDIS) in Australia and reflect on the underlying agendas of reform. Specifically, this research aimed to: (1) examine the substantive content of the NDIS legislative, operational and reform documentation, (2) assess changes in objects, principles and issues over time, and (3) discuss the implications of these shifting logics and agendas. To achieve this, text mining approaches were applied to ten key NDIS documents from 2011 to 2019.

The findings included a low prevalence of ‘rights’-based terminology, sustained attention to Scheme ‘costs’ but limited latterly attention to ‘sustainability’, and increasing prominence of interpersonal (e.g., ‘family’, ‘community’) and decision-making terminology (e.g., ‘decision’, ‘review’). How these shifts have influenced subsequent proposed reforms is explored and ongoing dilemmas about designing policy that ensures rights and entitlements, while balancing cost, sustainability and consistency are identified.
Three Trajectories in Nineteenth-Century Anglican Biblical Interpretation: From Narrow to Broad
Authors: Hartin Cole William
Published: April 2024

Contemporary studies of Anglican biblical interpretation in the nineteenth century are scant. Those that do exist tend to paint the biblical interpretation of the period as unidimensional and flat. This paper highlights diverse ways the Bible was interpreted by Anglicans in the nineteenth century by looking at the writings of Charles Simeon, Benjamin Jowett, and Christina Rossetti. Each has interesting and distinct ways of approaching the Bible. The paper analyzes their interpretive practices before tracing them to the present and drawing out significant historical themes in each.
Continued Convergence After the Occurrence of a Slab Break‐Off: The Case of the Cyprian Arc
Authors: Granot R. , Hamiel Y. , Kanari M. , Kurant S. , Katz O.
Published: April 2024

The detachment (i.e., break‐off) of down‐going subducting oceanic slabs is a major geodynamic event with far‐reaching consequences, one of which is the reduction of the slab pull force acting on the trailing plate. We investigate the motion of the Sinai Microplate where a recent (∼1 Myr ago) slab break‐off occurred along its sole converging plate boundary (Cyprian Arc) with the overriding Anatolia Microplate. Based on new bathymetric mapping, high‐resolution seismic reflection imaging, geodetic and earthquake data, we show that Sinai is actively moving in a northwest direction with respect to Nubia. Our results indicate that despite the recent slab break‐off, Sinai has and is still being pulled (or pushed) toward the overriding Anatolia Microplate. The continued convergence possibly occurs because of a persistent slab pull force, a suction force induced by the down‐going detached slab and/or by the upper mantle flow induced by the Afar Plume.
Exploring the Potential of Long Short‐Term Memory Networks for Predicting Net CO2 Exchange Across Various Ecosystems With Multi‐Source Data
Authors: Huang Chengcheng , He Wei , Liu Jinxiu , Nguyen Ngoc Tu , Yang Hua , Lv Yiming , Chen Hui , Zhao Mengyao
Published: April 2024

Upscaling flux tower measurements based on machine learning (ML) algorithms is an essential approach for large‐scale net ecosystem CO2 exchange (NEE) estimation, but existing ML upscaling methods face some challenges, particularly in capturing NEE interannual variations (IAVs) that may relate to lagged effects. With the capacity to characterize temporal memory effects, the Long Short‐Term Memory (LSTM) networks are expected to help solve this problem. Here we explored the potential of LSTM for predicting NEE across various ecosystems using flux tower data over 82 sites in North America. The LSTM model with differentiated plant function types (PFTs) demonstrates the capability to explain 79.19% (R2 = 0.79) of the monthly variations in NEE within the testing set, with RMSE and Mean Absolute Error values of 0.89 and 0.57 g C m−2 d−1 respectively (r = 0.89, p < 0.001). Moreover, the LSTM model performed robustly in predicting cross‐site variability, with 67.19% of the sites that can be predicted by both LSTM models with and without distinguished PFTs showing improved predictive ability. Most importantly, the IAV of predicted NEE highly correlated with that in flux observations (r = 0.81, p < 0.001), clearly outperforming that by the random forest model (r = −0.21, p = 0.011). Among all nine PFTs, solar‐induced chlorophyll fluorescence, downward shortwave radiation, and leaf area index are the most important variables for explaining NEE variations, collectively accounting for approximately 54.01% in total. This study highlights the great potential of LSTM for improving carbon flux upscaling with multi‐source remote sensing data.
Surface Resistance Controls Differences in Evapotranspiration Between Croplands and Prairies in U.S. Corn Belt Sites
Authors: Schreiner‐McGraw Adam P. , Baker John M. , Wood Jeffrey D. , Abraha Michael , Chen Jiquan , Griffis Timothy J. , Robertson G. Phillip
Published: April 2024

Water returned to the atmosphere as evapotranspiration (ET) is approximately 1.6x global river discharge and has wide‐reaching impacts on groundwater and streamflow. In the U.S. Midwest, widespread land conversion from prairie to pasture to cropland has altered spatiotemporal patterns of ET, yet there is not consensus on the direction of change or the mechanisms controlling changes. We measured ET at three locations within the Long‐Term Agroecosystem Research network along a latitudinal gradient with paired rainfed cropland and prairie sites at each location. At the northern locations, the Upper Mississippi River Basin (UMRB) and Kellogg Biological Station (KBS), the cropland has annual ET that is 84 and 29 mm/year (22% and 5%) higher, respectively, caused primarily by higher ET during springtime when fields are fallow. At the southern location, the Central Mississippi River Basin (CMRB), the prairie has 69 mm/year (11%) higher ET, primarily due to a longer growing season. Differences in climate and that the CMRB prairie is remnant native prairie, while the UMRB and KBS prairies are restored, make it challenging to attribute differences to specific mechanisms. To accomplish this, we examine the energy balance using the Two‐Resistance Method (TRM). Results from the TRM demonstrate that higher surface conductance in croplands is the primary factor leading to higher springtime ET from croplands, relative to prairies. Results from this study provide insight into impacts of warm season grasses on the hydrology of the U.S. Corn Belt by providing a mechanistic understanding of how land use change affects the water budget.
TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2
Authors: Li Jun , Zhang Qian , Guan Yupeng , Liao Dingzhun , Chen Huikun , Xiong Haiyun , Sheng Yiyu , Chen Xianju , Pang Jun
Published: April 2024

Abnormal lipid metabolism and lipid accumulation are characteristic hallmarks of renal cell carcinoma (RCC). While there is prior evidence closely linking such lipid accumulation within RCC cells and consequent tumorigenesis, the mechanisms underlying this process remain incompletely understood. In this study, a series of bioinformatics analyses were initially performed by screening RCC databases and gene sets, ultimately leading to the identification of TRIB3 as an oncogene that functions as a central regulator of lipid metabolism. TRIB3 overexpression was observed in both RCC patient tumor tissues and cell lines, and this upregulation was correlated with a worse RCC patient prognosis. When TRIB3 was knocked down, this resulted in a reduction in lipid accumulation and the consequent induction of endoplasmic reticulum (ER) stress-related apoptotic cell death. At the molecular level, interactions between TRIB3 and PLIN2 were found to abrogate TEB4-mediated PLIN2 ubiquitination and consequent degradation, thus maintaining higher PLIN2 expression levels. This simultaneously helps facilitate the accumulation of lipids while preserving ER homeostasis, thus driving accelerated RCC tumor progression. This TRIB3-PLIN2 axis thus represents a promising new target for efforts to treat RCC.
Atomic reconstruction for realizing stable solar-driven reversible hydrogen storage of magnesium hydride
Authors: Zhang Xiaoyue , Ju Shunlong , Li Chaoqun , Hao Jiazheng , Sun Yahui , Hu Xuechun , Chen Wei , Chen Jie , He Lunhua , Xia Guanglin , Fang Fang , Sun Dalin , Yu Xuebin
Published: April 2024

Reversible solid-state hydrogen storage of magnesium hydride, traditionally driven by external heating, is constrained by massive energy input and low systematic energy density. Herein, a single phase of Mg2Ni(Cu) alloy is designed via atomic reconstruction to achieve the ideal integration of photothermal and catalytic effects for stable solar-driven hydrogen storage of MgH2. With the intra/inter-band transitions of Mg2Ni(Cu) and its hydrogenated state, over 85% absorption in the entire spectrum is achieved, resulting in the temperature up to 261.8 °C under 2.6 W cm−2. Moreover, the hydrogen storage reaction of Mg2Ni(Cu) is thermodynamically and kinetically favored, and the imbalanced distribution of the light-induced hot electrons within CuNi and Mg2Ni(Cu) facilitates the weakening of Mg-H bonds of MgH2, enhancing the “hydrogen pump” effect of Mg2Ni(Cu)/Mg2Ni(Cu)H4. The reversible generation of Mg2Ni(Cu) upon repeated dehydrogenation process enables the continuous integration of photothermal and catalytic roles stably, ensuring the direct action of localized heat on the catalytic sites without any heat loss, thereby achieving a 6.1 wt.% H2 reversible capacity with 95% retention under 3.5 W cm−2.
Full integration of highly stretchable inorganic transistors and circuits within molecular-tailored elastic substrates on a large scale
Authors: Kang Seung-Han , Jo Jeong-Wan , Lee Jong Min , Moon Sanghee , Shin Seung Bum , Choi Su Bin , Byeon Donghwan , Kim Jaehyun , Kim Myung-Gil , Kim Yong-Hoon , Kim Jong-Woong , Park Sung Kyu
Published: April 2024

The emergence of high-form-factor electronics has led to a demand for high-density integration of inorganic thin-film devices and circuits with full stretchability. However, the intrinsic stiffness and brittleness of inorganic materials have impeded their utilization in free-form electronics. Here, we demonstrate highly integrated strain-insensitive stretchable metal-oxide transistors and circuitry (442 transistors/cm2) via a photolithography-based bottom-up approach, where transistors with fluidic liquid metal interconnection are embedded in large-area molecular-tailored heterogeneous elastic substrates (5 × 5 cm2). Amorphous indium-gallium-zinc-oxide transistor arrays (7 × 7), various logic gates, and ring-oscillator circuits exhibited strain-resilient properties with performance variation less than 20% when stretched up to 50% and 30% strain (10,000 cycles) for unit transistor and circuits, respectively. The transistors operate with an average mobility of 12.7 ( ± 1.7) cm2 V−1s−1, on/off current ratio of > 107, and the inverter, NAND, NOR circuits operate quite logically. Moreover, a ring oscillator comprising 14 cross-wired transistors validated the cascading of the multiple stages and device uniformity, indicating an oscillation frequency of ~70 kHz.
Decreased Indian Ocean Dipole variability under prolonged greenhouse warming
Authors: Kim Soong-Ki , Park Hyo-Jin , An Soon-Il , Liu Chao , Cai Wenju , Santoso Agus , Kug Jong-Seong
Published: April 2024

The Indian Ocean Dipole (IOD) is a major climate variability mode that substantially influences weather extremes and climate patterns worldwide. However, the response of IOD variability to anthropogenic global warming remains highly uncertain. The latest IPCC Sixth Assessment Report concluded that human influences on IOD variability are not robustly detected in observations and twenty-first century climate-model projections. Here, using millennial-length climate simulations, we disentangle forced response and internal variability in IOD change and show that greenhouse warming robustly suppresses IOD variability. On a century time scale, internal variability overwhelms the forced change in IOD, leading to a widespread response in IOD variability. This masking effect is mainly caused by a remote influence of the El Niño–Southern Oscillation. However, on a millennial time scale, nearly all climate models show a long-term weakening trend in IOD variability by greenhouse warming. Our results provide compelling evidence for a human influence on the IOD.
Comparison of efficacy and safety of equivalent doses of remimazolam versus propofol for gastroscopy anesthesia in elderly patients
Authors: Chen Di , Liao Min , Wu Xiao-ru , Zhao Tang-yuan-meng , Sun Hu
Published: April 2024

Remimazolam, a novel intravenous anesthetic, has been proven to be safe and efficacious in the gastroscopy setting among the elderly. However, reports comparing the effectiveness and safety of using equivalent doses of remimazolam with propofol have not been seen. The aim of this study was to compare the sedation efficacy and safety of the 95% effective doses (ED95) of remimazolam versus propofol combined with sufentanil in the gastroscopy setting among the elderly. In the first step of this two-step study, a modified up-and-down method was used to calculate the ED95 of remimazolam and propofol when combined with 0.1 µg/kg sufentanil in inhibiting body movement of elderly patients undergoing gastroscopy. In the second step, ED95 of both agents calculated in the first step were administered, endpoints of efficacy, safety, and incidence of adverse events were compared. A total of 46 individuals completed the first step. The ED95 of remimazolam was 0.163 mg/kg (95% CI 0.160–0.170 mg/kg), and that of propofol was 1.042 mg/kg (95% CI 1.007–1.112 mg/kg). In the second step, 240 patients completed the trial. The anesthetic effective rates of the remimazolam group and the propofol group were 78% and 83%, respectively, with no statistical difference (P = 0.312). Patients in the remimazolam group had more stable circulatory functions (P < 0.0001) and a lower incidence of pain on injection (3.3% vs. 19.5%, P < 0.0001). The incidence of hypotension was low in the remimazolam versus propofol group (15.6% vs. 39.0%, P < 0.0001). Overall adverse event was low in the remimazolam versus propofol group (21.3% vs. 62.7%, P < 0.0001).In this study, we found that when anesthesia was administered to elderly gastroscopy patients based on 95% effective doses of remimazolam and propofol, remimazolam was as effective as propofol, but was safer with a lower incidence of adverse events.

Study registration: Chinese Clinical Trial Registry, ChiCTR2000034234. Registered 29/06/2020, https://www.chictr.org.cn.
Exploring bi-carbazole-linked triazoles as inhibitors of prolyl endo peptidase via integrated in vitro and in silico study
Authors: Ullah Saeed , Mansoor Farheen , Khan Salman Ali , Jabeen Uzma , Almars Amany I. , Almohaimeed Hailah M. , Basri Ahmed M. , Alshabrmi Fahad M.
Published: April 2024

A serine protease called prolyl endopeptidase (PEP) hydrolyses the peptide bonds on the carboxy side of the proline ring. The excessive PEP expression in brain results in neurodegenerative illnesses like dementia, Alzheimer’s disease, and Parkinson's disease. Results of the prior studies on antioxidant activity, and the non-cytotoxic effect of bi-carbazole-linked triazoles, encouraged us to extend our studies towards its anti-diabetic potential. Hence, for this purpose all compounds 1–9 were evaluated to reveal their anti-prolyl endo peptidase activity. Fortunately, seven compounds resulted into significant inhibitory capability ranging from 26 to 63 µM. Among them six compounds 4–9 exhibited more potent inhibitory activity with IC50 values 46.10 ± 1.16, 42.30 ± 1.18, 37.14 ± 1.21, 26.29 ± 0.76, 28.31 ± 0.64 and 31.11 ± 0.84 µM respectively, while compound 3 was the least active compound in the series with IC50 value 63.10 ± 1.58 µM comparing with standard PEP inhibitor bacitracin (IC50 = 125 ± 1.50 µM). Moreover, mechanistic study was performed for the most active compounds 7 and 8 with Ki values 24.10 ± 0.0076 and 23.67 ± 0.0084 µM respectively. Further, the in silico studies suggested that the compounds exhibited potential interactions and significant molecular conformations, thereby elucidating the structural basis for their inhibitory effects.