bluuebunny/crossref_metadata_2025 huggingface dataset:
An optimized dynamic attribute-based searchable encryption scheme
Authors: Khan Shahzad , Khan Shawal , Waheed Abdul , Mehmood Gulzar , Zareei Mahdi , Alanazi Faisal
Published: October 2024

Cloud computing liberates enterprises and organizations from expensive data centers and complex IT infrastructures by offering the on-demand availability of vast storage and computing power over the internet. Among the many service models in practice, the public cloud for its operation cost saving, flexibility, and better customer support popularity in individuals and organizations. Nonetheless, this shift in the trusted domain from the concerned users to the third-party service providers pops up many privacy and security concerns. These concerns hindrance the wide adaptation for many of its potential applications. Furthermore, classical encryption techniques render the encrypted data useless for many of its valuable operations. The combined concept of attribute-based encryption (ABE) and searchable encryption (SE), commonly known as attribute-based keyword searching (ABKS), emerges as a promising technology for these concerns. However, most of the contemporary ABE-based keyword searching schemes incorporate costly pairing and computationally heavy secret sharing mechanisms for its realization. Our proposed scheme avoids the expensive bilinear pairing operation during the searching operation and costly Lagrange interpolation for secret reconstruction. Besides, our proposed scheme enables the updation of access control policy without entirely re-encrypting the ciphertext. The security of our scheme in the selective-set model is proved under the Decisional Bilinear Diffie-Hellmen (DBDH) assumption and collision-free. Finally, the experimental results and performance evaluation demonstrate its communication and overall efficiency.
A physically inspired approach to coarse-graining transcriptomes reveals the dynamics of aging
Authors: Li Tao , Mani Madhav
Published: October 2024

Single-cell RNA sequencing has enabled the study of aging at a molecular scale. While substantial progress has been made in measuring age-related gene expression, the underlying patterns and mechanisms of aging transcriptomes remain poorly understood. To address this gap, we propose a physics-inspired, data-analysis approach to extract additional insights from single-cell RNA sequencing data. By considering the genome as a many-body interacting system, we leverage central idea of the Renormalization Group to construct an approach to hierarchically describe aging across a spectrum of scales for the gene expresion. This framework provides a quantitative language to study the multiscale patterns of aging transcriptomes. Overall, our study demonstrates the value of leveraging theoretical physics concepts like the Renormalization Group to gain new biological insights from complex high-dimensional single-cell data.
Prevalence and factors associated with peripheral neuropathy in a setting of retail pharmacies in Malaysia–A cross-sectional study
Authors: Ching Siew Mooi , Lee Kai Wei , Yusof Khan Abdul Hanif Khan , Devaraj Navin Kumar , Cheong Ai Theng , Yap Sook Fan , Hoo Fan Kee , Wan Sulaiman Wan Aliaa , Loh Wei Chao , Chong Shen Horng , Patil Mansi , Ramachandran Vasudevan
Published: October 2024

Peripheral neuropathy is a common cause for neurological consultation, especially among those with diabetes mellitus. However, research on peripheral neuropathy among the general population is lacking in Malaysia. This study aimed to determine the prevalence and factors associated with peripheral neuropathy in a setting of retail pharmacies. This cross-sectional study of 1283 participants was conducted at retail pharmacies in Selangor. Peripheral neuropathy was defined as the final score in the mild to severe category in the severity rating scale using a biothesiometer. SPSS version 26 was used to perform the analysis. Multiple logistic regressions were used to determine the factors associated with peripheral neuropathy. The prevalence of peripheral neuropathy based on the biothesiometer was 26.5%. According to multiple logistic regression, the predictors of peripheral neuropathy were those who have diabetes (AOR = 3.901), aged more than 50 years (AOR = 3.376), have secondary education or below (AOR = 2.330), are male (AOR = 1.816), and have underlying hypertension (AOR = 1.662). Peripheral neuropathy is a reasonably prevalent condition, affecting a quarter of the general population, and often goes undiagnosed. It is crucial for healthcare providers to proactively screen for peripheral neuropathy, particularly in high-risk populations, to prevent potential complications.
Development and characterisation of orally disintegrating flurbiprofen tablets using SeDeM-ODT tool
Authors: Fatima Syeda Sara , Zafar Farya , Ali Huma , Raees Fahim , Naqvi Ghazala Raza , Alam Shazia , Yasmin Riffat , Tariq Anum , Saeed Rehana , Khan Sohail
Published: October 2024

In this study, SeDeM–ODT parametric tests were performed to determine the use of ludipress as a directly compressible tableting excipient for the development of a flurbiprofen orally disintegrating tablet. The preformulation features of different formulations (F1 –F9) were analyzed by the SeDeM–ODT tool which showed that all the powder blends were appropriate for direct compression since all the blends had index of good compressibility and bucodispersibility (IGCB) values above 5, signifying direct compression is the most appropriate method. The powder blend of the optimized formulation was assessed by the DSC–TGA technique. The optimization of nine different formulations blends of orally disintegrating tablets (ODTs) was prepared in various ratios by the implementation of design of experiments (DoE), using the central composite design by selecting ludipress (X1) (49–55%) and croscarmellose sodium (X2) (1–5%) while hardness, friability, and disintegration tests were selected as responses. The optimized formulations were evaluated by various tests and the results indicated that all the formulations were found to be in adequate range. Formulations were subjected to stability studies at accelerated states following ICH guidelines. Shelf life was found to be 51.144–56.186 months. Results of multiple-point dissolution studies revealed that formulations followed the Higuchi kinetic model. This study revealed that the SeDeM—ODT tool has been successfully used to determine the compression behavior of active compounds and their powder blends for the direct compression (DC) method in formulating flurbiprofen–ODT tablets.
The impact of prediabetes on preclinical atherosclerosis in general apparently healthy population: A cross-sectional study
Authors: Zieleniewska Natalia Anna , Jamiołkowski Jacek , Chlabicz Małgorzata , Łukasiewicz Adam , Dubatówka Marlena , Kondraciuk Marcin , Sowa Paweł , Kowalska Irina , Kamiński Karol Adam
Published: October 2024

Background

The hypothesis that not only diagnosed diabetes (DM), but also milder dysglycemia may affect the development of atherosclerosis still requires further study. In our population-based study, we aimed to evaluate the impact of prediabetic state on preclinical atherosclerosis and whether it may affect the cardiovascular risk (CVR) in the general population.

Methods

The analysis was a part of the Bialystok PLUS cohort study and represented a random sample of Bialystok (Poland) residents aged 20–79 years at the time of sampling (July 2017-January 2023). The cross-sectional analysis included 1431 participants of a population-based study (mean age 46.82 years). Comprehensive biochemical assessments were performed. An Oral Glucose Tolerance Test (OGTT) was performed on fasting patients who did not report having a DM.

Results

The population with prediabetes, based on HbA1c and OGTT, accounted for more than half of the study participants (n = 797, 55.7%). Atherosclerotic plaques in the carotid arteries were significantly more common in individuals with prediabetes considering all CVR categories. Prediabetes was associated with the occurrence of more advanced preclinical atherosclerosis, especially in the low to moderate CVR category. Serum glucose concentration after 1h and HbA1c proved to be statistically significant indicators of the presence of atherosclerotic plaques in ultrasound (respectively, AUC = 0.73 and 0.72). In multivariate logistic regression, prediabetes was independently associated with significantly increased risk of preclinical atherosclerosis (OR = 1.56, 95% CI 1.09–2.24), along with CVR categories, pulse wave velocity and central blood pressure augmentation index.

Conclusions

Prediabetes is associated with the occurrence and progression of the preclinical atherosclerosis. Importantly, many of those patients are in the low to moderate cardiovascular risk category, hence may have a severely underestimated risk. Inclusion of prediabetes into CVR assessment may improve risk stratification. An early identification of dysglycemic population is necessary to effectively implement the cardiovascular and metabolic prevention measures.
Structures of multivariables affecting literacy: Cluster analysis
Authors: Akarsu Remziye , Bumin Gonca , Celik Yusuf
Published: October 2024

Early literacy skills, the foundational abilities necessary for the development of literacy, must be examined holistically in preschool children. This study aimed to investigate early literacy skills in preschool children and determine how variables related to literacy development can be clustered by using a dendrogram. The study was conducted on 166 preschool children (75 female, 91 male; mean age: 65.9±4.4 months). Hierarchical cluster analysis (CA) was used to find the variable clustering trends. The 44 variables related to literacy (sociodemographic factors related to the child and family, child–parent relationship, child’s behavior, and social, sensory integration, motor, and auditory linguistic skills) that were closest to each other in the dendrogram were clustered, and the situation was summarized by reducing them to two main clusters and six sub-clusters. This study elaborates on the implications of reducing multivariate complexity using CA. It is recommended that the relationships among the variables in this dendrogram structure are considered when new hypotheses and studies related to early literacy are designed.
NRO-stylization: A novel algorithm for regular octahedral stylization aesthetic modeling of three-dimensional surface mesh
Authors: Dong Fuxin , Tang Yingying , Zhang Jialing , Qian Kun
Published: October 2024

Stylization of 3D shapes has been a prominent topic in computer graphics. Geometric stylization, as a category within 3D shape stylization, has garnered widespread attention due to its distinctive geometric aesthetics. This paper introduces a novel and simplified method for achieving regular octahedral stylization, capable of transforming the input shape into the regular octahedral style while preserving the content of the original shape. The proposed method achieves regular octahedral stylization by using face normals. Its implementation is straightforward because it incurs a cost only in terms of solving several linear systems. To demonstrate the effectiveness and robustness of the proposed method, extensive tests were conducted on models with varying levels of complexity and topological structures. The results highlight the exceptional capability of the proposed method to generate geometric shapes with an aesthetically pleasing regular octahedral style.
Children from the poor families seem to grow up earlier: An examination of how family economy stress links to career exploration
Authors: Cheng Xiao-li , Ma Guang-ya , Zhang Lu-yao , Lu Lei
Published: October 2024

Career exploration, a critical antecedent to college students’ career choices and employment, offers essential guidance for their career development. However, existing research has not explored how changes in family economic stress impact career exploration. Drawing on social cognitive career theory, this study aims to deepen our understanding of the complex interplay between family economic stress and career exploration among vocational school students. We tested our hypotheses using three-time lagged data collected from 600 vocational school students studying in mainland China. As expected, family economic stress positively predicts career exploration via love of money. Additionally, both students’ effective part-time behavior and teacher support were found to positively moderate the indirect relationship between family economic stress and career exploration through love of money. We attempt to highlight the broader implications of understanding the nuanced ways in which economic background shapes career exploration. Theoretical and practical implications are discussed.
Optimal strategies for contract farming supply chain with government subsidies under e-commerce assistance to farmers
Authors: Wu Zhengxiang , Zhu Jinlei
Published: October 2024

The agricultural issue is a focal point of concern for each country, and e-commerce assistance to farmers, as an emerging model, is gaining increasing attention. Considering this trend, this paper bases on e-commerce assistance to farmers and considers four types of government subsidies: no subsidy, price subsidy model with the farmer as the subsidy target, price subsidy model with the e-commerce platform as the subsidy target, and area subsidy model. Based on this, a game model of the contract farming supply chain involving a farmer and an e-commerce platform was established to explore the optimal decision-making in the contract farming supply chain considering various government subsidies under the background of e-commerce assistance to farmers. The results indicate that: (1) Consumer preference for supporting farmers and consumer premiums can stimulate the farmer to expand farm size, increase agricultural production, increase the purchase price of agricultural products and promote the growth of profits for the farmer and the e-commerce platform, contributing to the growth of social welfare. Output volatility can lead to a decrease in farm size and a reduction in the purchase price of agricultural products. (2) Government subsidies can support the farmer in expanding farm size and contribute to increased profits for the farmer and the e-commerce platform. However, government subsidies do not universally have a positive impact on every variable. The influence of government subsidies on the purchase price of agricultural products is contingent upon the method of subsidy distribution. Similarly, the effects of government subsidies on social welfare are influenced by factors such as price elasticity and agricultural productions per unit area. (3) From the perspectives of farm size, the purchase price of agricultural products, and profits of the farmer and the e-commerce platform, the government will have different and more targeted subsidy models, and the corresponding subsidy models are influenced by the agricultural productions per unit area. The research conclusion can provide references for optimal decision-making in contract farming under the model of e-commerce assistance to farmers.
Sweet enhancers of polymerase chain reaction
Authors: Xie Binghua , Chen Jia , Wang Zhounan , Yin Qiao , Dai Zhong-Min
Published: October 2024

Although faster and powerful, polymerase chain reaction (PCR) often failed to amplify targets efficiently. Numerous PCR enhancers have been used to increase the amplification efficiency of difficult DNA targets. However, there is no systematic comparison of their effects in normal and difficult PCR conditions. In this paper, we have selected nine different PCR enhancers that can promote the PCR amplification efficiency. We have compared their effect in Taq DNA polymerase thermostability, inhibitor resistance, and amplification of various DNA targets. Although the PCR enhancers more or less reduced the amplification efficiency of DNA fragments with moderate GC-content, they were able to improve the amplification efficiency and specificity of GC-rich fragments. Betaine outperformed the other enhancers in amplification of GC-rich DNA fragments, thermostabilizing Taq DNA polymerase, and inhibitor tolerance. Sucrose and trehalose showed similar effect in thermostabilizing Taq DNA polymerase and inhibitor tolerance, while they showed mildest inhibitory effect on normal PCR. For GC-rich region-containing long DNA fragment amplification, 1 M betaine, 0.5 M betaine + 0.2 M sucrose, or 1 M betaine + 0.1 M sucrose can be used to effectively promote the amplification, while keep their negative effect in amplification of normal fragment to a minimal level.
Effects of menstrual cycle on cognitive function, cortisol, and metabolism after a single session of aerobic exercise
Authors: Mirzaei Khalil Abadi Maryam , Hemmatinafar Mohammad , Koushkie Jahromi Maryam
Published: October 2024

Aim

This study aimed to investigate the effects of the two pre-ovulatory and mid-luteal phases of the menstrual cycle on cognitive function, as well as possible mediators of metabolism and salivary cortisol, at rest and after an aerobic exercise session.

Study design

Twelve active young unmarried women aged 22–30 years volunteered to participate in the study. The participants performed a 20-min exercise session on a cycle ergometer at 60–70% of their reserve heart rate twice, during the follicular (pre-ovulation: days 7–10) and luteal (mid-luteal: days 21–24) phases of the menstrual cycle. Saliva samples were collected to measure cortisol. Fat utilization, respiratory exchange ratio (RER), and energy expenditure (during exercise) were measured using a spiroergometer. Cognitive function was assessed using the Stroop test. Cognitive function and cortisol levels were measured before and after each exercise session.

Results

The findings of this study indicated no significant differences in variables during the resting follicular and luteal phases. Cortisol levels and cognitive function were increased after exercise compared with before exercise in both the follicular and luteal phases. Cortisol and fat utilization after exercise were significantly higher in the follicular phase than in the luteal phase. There were no significant differences between the follicular and luteal phasesregarding the effects of exercise on cognitive function, energy expenditure, and RER.

Conclusion

In general, the follicular and luteal phases of menstruation may not affect cognitive function in response to a single aerobic exercise session, although they change some metabolic factors and cortisol.
Genetic and pathogenic potential of highly pathogenic avian influenza H5N8 viruses from live bird markets in Egypt in avian and mammalian models
Authors: Moatasim Yassmin , Aboulhoda Basma Emad , Gomaa Mokhtar , El Taweel Ahmed , Kutkat Omnia , Kamel Mina Nabil , El Sayes Mohamed , GabAllah Mohamed , Elkhrsawy Amany , AbdAllah Hend , Kandeil Ahmed , Ali Mohamed Ahmed , Kayali Ghazi , El-Shesheny Rabeh
Published: October 2024

Since its first isolation from migratory birds in Egypt in 2016, highly pathogenic avian influenza (HPAI) H5N8 has caused several outbreaks among domestic poultry in various areas of the country affecting poultry health and production systems. However, the genetic and biological properties of the H5N8 HPAI viruses have not been fully elucidated yet. In this study, we aimed to monitor the evolution of circulating H5N8 viruses and identify the pathogenicity and mammalian adaptation in vitro and in vivo. Three H5N8 HPAI viruses were used in this study and were isolated in 2021–2022 from poultry and wild birds during our routine surveillance. RNA extracts were subjected to full genome sequencing. Genetic, phylogenetic, and antigenic analyses were performed to assess viral characteristics and similarities to previously isolated viruses. Phylogenetic analysis showed that the hemagglutinin genes of the three isolates belonged to clade 2.3.4.4b and grouped with the 2019 viruses from G3 with high similarity to Russian and European lineages. Multiple basic amino acids were observed at cleavage sites in the hemagglutinin proteins of the H5N8 isolates, indicating high pathogenicity. In addition, several mutations associated with increased virulence and polymerase activity in mammals were observed. Growth kinetics assays showed that the H5N8 isolate is capable of replicating efficiently in mammalian cells lines. In vivo studies were conducted in SPF chickens (White Leghorn), mice, and hamsters to compare the virological characteristics of the 2022 H5N8 isolates with previous H5N8 viruses isolated in 2016 from the first introduction. The H5N8 viruses caused lethal infection in all tested chickens and transmitted by direct contact. However, we showed that the 2016 H5N8 virus causes a higher mortality in chickens compared to 2022 H5N8 virus. Moreover, the 2022 virus can replicate efficiently in hamsters and mice without preadaptation causing systemic infection. These findings underscore the need for continued surveillance of H5 viruses to identify circulating strains, determine the commercial vaccine’s effectiveness, and identify zoonotic potential.
Clinical and socioeconomic predictors of hospital use and emergency department visits among children with medical complexity: A machine learning approach using administrative data
Authors: Sidra Michael , Pietrosanu Matthew , Zwicker Jennifer , Johnson David Wyatt , Round Jeff , Ohinmaa Arto
Published: October 2024

Objectives

The primary objective of this study was to identify clinical and socioeconomic predictors of hospital and ED use among children with medical complexity within 1 and 5 years of an initial discharge between 2010 and 2013. A secondary objective was to estimate marginal associations between important predictors and resource use.

Methods

This retrospective, population-cohort study of children with medical complexity in Alberta linked administrative health data with Canadian census data and used tree-based, gradient-boosted regression models to identify clinical and socioeconomic predictors of resource use. Separate analyses of cumulative numbers of hospital days and ED visits modeled the probability of any resource use and, when present, the amount of resource use. We used relative importance in each analysis to identify important predictors.

Results

The analytic sample included 11 105 children with medical complexity. The best short- and long-term predictors of having a hospital stay and number of hospital days were initial length of stay and clinical classification. Initial length of stay, residence rurality, and other socioeconomic factors were top predictors of short-term ED use. The top predictors of ED use in the long term were almost exclusively socioeconomic, with rurality a top predictor of number of ED visits. Estimates of marginal associations between initial length of stay and resource use showed that average number of hospital days increases as initial length of stay increases up to approximately 90 days. Children with medical complexity living in rural areas had more ED visits on average than those living in urban or metropolitan areas.

Conclusions

Clinical factors are generally better predictors of hospital use whereas socioeconomic factors are more predictive of ED use among children with medical complexity in Alberta. The results confirm existing literature on the importance of socioeconomic factors with respect to health care use by children with medical complexity.
First-year evaluation of a campus-wide, cross-disciplinary scholarly writing development program supported by a center for biomedical research excellence (COBRE)
Authors: Franks Amy M. , Teeter Benjamin S. , Davis Payton , Allred Mallory , Landes Reid D. , Koturbash Igor , Weber Judith
Published: October 2024

Background

Scholarly publications are important indicators of research productivity and investigator development in Centers of Biomedical Research Excellence (COBREs). However, no information is available to describe implementation and evaluation of writing development programs within COBREs. Therefore, this paper aimed to evaluate the first year of a campus-wide COBRE-supported writing program.

Methods

A convergent parallel mixed-methods design (QUAN + QUAL) was used. All writing program participants were invited to complete post-participation surveys, and a subgroup was selected using purposive sampling to complete individual semi-structured interviews. Descriptive statistics were used to characterize survey data, and qualitative content analysis was employed to analyze interview data. Self-determination theory served as the theoretical framework by which themes were developed and interpreted.

Results

Professional staff, post-doctoral fellows, and faculty from all academic ranks (n = 29) participated in the writing program during its first year. Survey respondents (n = 18, response rate 62%) rated social support (89%), group accountability (89%), hearing group members’ writing goals (78%), receiving group advice (67%), and setting a weekly writing schedule (56%) as beneficial program components. Participants rated program benefits such as breaking away from other responsibilities, staying on task with writing goals, and receiving social support as most beneficial. During interviews, participants (n = 14) described five major themes related to the benefits received: 1) belonging to a community of writers; 2) managing writing-related emotions; 3) improved productivity; 4) establishing helpful writing habits; and 5) improved motivation for scholarly writing.

Conclusions

This first-year programmatic evaluation demonstrates the writing program’s effectiveness as a campus-level development resource supported by a research center. Both survey and interview data affirmed that participants perceived autonomy, competence, and relatedness were supported through participation in the writing program. Participants placed particular emphasis on the writing program’s successful development of a community of scholarly writers.
The dietary fiber and micronutrient composition of traditional foods from Lebanon and their contribution to dietary adequacy: A call for action
Authors: Hoteit Maha , Zoghbi Edwina , Rady Alissar , Shankiti Iman , Sacre Yonna , Hanna-Wakim Lara , Mahfouz Rana , Ibrahim Carla , Al-Jawaldeh Ayoub
Published: October 2024

Traditional Lebanese cuisine is based on traditional dishes, where Arabic sweets play an important role in daily consumption. This study focuses on the evaluation of total fibers and trace elements, especially vitamins A, D, E, and C of traditional foods and Arabic sweets commonly consumed in Lebanon by chemical analysis. A total of thirty types of Arabic sweets were chosen from reputable confectionery establishments, while thirty varieties of traditional Lebanese dishes were collected from central kitchens in the main Lebanese governorates. It was discovered that 23% percent of Arabic sweets and 30% of traditional dishes were rich in total dietary fiber. Moreover, Arabic sweets had trace amounts of vitamin A, vitamin E, and vitamin C. In specific sweets, vitamin A content showed variability, with values ranging from 8ug to 15 ug per 100 g of edible portions. Most of the traditional dishes contained traces of vitamin C. However, Tabboula stood out as the only dish that contributed to over 23% of the recommended daily value for vitamin C. Trace amounts of vitamins A, D, E, and C were present in almost all traditional Lebanese foods and Arabic sweets. This study revealed that these foods lack essential micronutrients and total dietary fibers.
The prevalence and determinants of unmet healthcare needs in Bulgaria
Authors: Maslyankov Ivan , Hernández Mónica
Published: October 2024

Self-reported unmet healthcare needs are a useful indicator of access to healthcare, but there is little research from low- and middle-income countries. This study sought to investigate the prevalence and determinants of unmet needs arising from wait times, distance/transportation and financial affordability in Bulgaria using European Health Interview Survey data. We explored associations between individual characteristics and the probability of reporting unmet need by fitting logistic regression models to the data. Unaffordability-related unmet needs were the most cited barrier to access. The largest proportion of people reported unmet dental care needs (14%) or unmet needs due to unaffordability of medicines (8%); distance/transportation problems were the least cited reason (3%). People with poor physical and mental health had a substantially higher probability of experiencing unmet needs. Those with a disability, less disposable income, less social support and lower educational attainment were also more likely to report unmet healthcare needs. People who lived in rural areas experienced specific barriers to access, most notably from distance or transportation issues. Unmet healthcare needs lead to inefficiencies for the healthcare system and are more prevalent among already disadvantaged societal groups. Ensuring better access to healthcare is therefore important from both the efficiency and equity perspectives.
Play as practice? Comparative analysis of preparation period and match adjustments in a basketball team’s performance
Authors: Monteiro Alan , Heiner Matthew , Fellingham Gilbert , Lamas Leonardo
Published: October 2024

In basketball, successful performance relies on the optimal use of top-down strategic guidance by coaches and bottom-up adjustments by players, requiring a preparation plan consistent with match demands. The aim of this study was to analyze the strategic-tactical tendencies between a basketball team’s preparation and match performance phases for a U16 men’s national team during a continental tournament. The team was composed by 12 players (aged 16 ± 0.4) with at least three years of participation in basketball competitions. Data from team strategy (the playbook), team practices, and match performance were integrated through a common set of variables in a decision support framework, the Team Learning Cycle (TLC). The influence of situational variables with respect to preparation and match performance consistency and efficiency was also investigated. The preparation phase significantly emphasized small-sided games focused on group-tactics-based attacks, combining offense and defense, usually in the set offense. During the matches, the set offense was also significantly prioritized. The frequency of group-tactics-based attacks increased relative to team plays from the group phase to the elimination phase (p < 0.05). Efficiency generally improved during close matches, suggesting successful team strategy learning and tactical autonomy from preparation to matches. Using consistency and efficiency together provided for an effective evaluation of a team’s preparation-performance relationship. This evidence underscores the importance of sensitive monitoring methods for establishing accurate associations between preparation and performance. Coaches can use this systematic procedure to critically examine their use of preparation time relative to match performance. Additionally, basketball managers may find that TLC-related evidence supports evaluating coaches’ multi-dimensional skills from a broader perspective than simply winning rates, offering a more objective and comprehensive assessment of coaching effectiveness.
BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection
Authors: Najarro Guillermo , Brackett Kevin , Woosley Hunter , Dorman Leah C. , Turon-Lagot Vincent , Khadka Sudip , Faeldonea Catya , Moreno Osvaldo Kevin , Negron Adriana Ramirez , Love Christina , Ward Ryan , Langelier Charles , McCarthy Frank , Gonzalez Carlos , Elias Joshua E. , Gardner Brooke M. , Arias Carolina
Published: October 2024

The Endoplasmic Reticulum (ER)-resident HSP70 chaperone BiP (HSPA5) plays a crucial role in maintaining and restoring protein folding homeostasis in the ER. BiP’s function is often dysregulated in cancer and virus-infected cells, conferring pro-oncogenic and pro-viral advantages. We explored BiP’s functions during infection by the Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic gamma-herpesvirus associated with cancers of immunocompromised patients. Our findings reveal that BiP protein levels are upregulated in infected epithelial cells during the lytic phase of KSHV infection. This upregulation occurs independently of the unfolded protein response (UPR), a major signaling pathway that regulates BiP availability. Genetic and pharmacological inhibition of BiP halts KSHV viral replication and reduces the proliferation and survival of KSHV-infected cells. Notably, inhibition of BiP limits the spread of other alpha- and beta-herpesviruses and poxviruses with minimal toxicity for normal cells. Our work suggests that BiP is a potential target for developing broad-spectrum antiviral therapies against double-stranded DNA viruses and a promising candidate for therapeutic intervention in KSHV-related malignancies.
Investigation the machining of the engineering polymers
Authors: Kovács Róbert , Korzenszky Péter , Keresztes Róbert
Published: October 2024

During the turning process, we have investigated the problems that can arise, such as avoiding the formation of flowchips, which are eliminated by sawing the workpiece longitudinally. Furthermore, we measured the main cutting forcesacting on the blade and the cutting forces in the feed direction at different feed rates, depths of grip and cutting speeds,and investigated possible correlations between these.Chips produced at different cutting parameters and with different materials were investigated. All turning operationsare carried out without emulsion and all other coolants for environmental and other reasons.The specific cutting resistances have been determined, which are essential for determining good tool utilisation andalso for planning the economics of machiningThe aim of this research is to define machining parameters that can be used in practice for the engineering plasticsunder investigation, so that the machining of these materials by turning can be made more economical.
Osmotic Treatment of Orange and Pink Sweet Potato-Mass Transfer Rate and Efficiency
Authors: Lončar Biljana , Filipović Vladimir , Šovljanski Olja , Pezo Lato , Knežević Violeta , Šuput Danijela , Aćimović Milica
Published: October 2024

Sweet potatoes (Ipomoea batatas) are globally cultivated due to its adaptability, high nutritional value, and short growing season, tolerance to high-temperature soils, low fertility, and minimal pest or disease issues, making it a valuable asset to the food industry. Osmotic treatment, a renowned preservation technique requiring mild temperatures and minimal energy, has gained prominence. Over ten years of research at the Faculty of Technology Novi Sad has pioneered the use of sugar beet molasses as an effective osmotic solution for drying different herbs, fruits, vegetables, and meat. This study specifically focused on osmotically treating samples of pink and orange sweet potatoes in sugar beet molasses (80% w/w) to explore the influence of solution temperatures (20°C, 35°C, and 50°C) and osmotic treatment durations (1h, 3h, and 5h) on mass transfer rate and treatment efficiency. The Principal Component Analysis (PCA) and color correlation analysis were employed to illustrate the connections between different sweet potato samples. Findings indicate that the mass transfer rate peaks at the onset of the process. Particularly with the highest temperature after 1h of osmotic treatment The highest values for RWL and RSG (13.33±0.02, 1.85±0.04 and 11.51±0.02, accordingly) were obtained for both orange ((15.19±0.08 g/(gi.s.w.·s)·105and 4.53±0.06 g/(gi.s.w.·s)·105) and pink sweet potato ((9.91±0.02 g/(gi.s.w.·s)·105 and 3.78±0.04 g/(gi.s.w.·s)·105), respectively. Notably, diffusion is most rapid within the initial three hours, suggesting potential reductions in processing time aligned with these results.
Effects of Foot Orthoses and Kinesio Tape on Spatiotemporal and Kinetic Gait Parameters during Running in Individuals with Flatfoot
Authors: Chen Hairong , Bíró István
Published: October 2024

Flatfoot is a common condition that influences gait and can cause discomfort for patients under higher loaded condition, such as running. Identifying the most effective treatment necessitates a comprehensive analysis of each therapy's impact on gait. Our research delved into the effects of Foot Orthosis and Kinesio Tape on the spatiotemporal and kinetic aspects of gait in individuals with flatfoot during running. Twenty female rearfoot strike runners with flatfoot participated in the running tasks at 3.3±5% m/s on the Zebris Medical GmbH treadmill. Gait data were collected under three conditions: shoe (A), shoe with Foot Orthoses (B), and shoe with Kinesio Tape (C). A one-way repeated measures ANOVA was employed to analyzed the gait parameters during the stance phase. Under conditions B and C, the foot rotation angle significantly decreased compared to condition A. Additionally, in condition B, it was significantly lower than in condition C. Under conditions B and C, the maximum force and pressure of forefoot significantly increased, whereas it in the midfoot significantly decreased, relative to condition A. Foot Orthosis and Kinesio Tape both effectively diminished peak midfoot pressure during running. Additionally, Foot Orthosis surpassed Kinesio Tape in enhancing foot stability and function throughout the running. These findings offered valuable insights for the selection of intervention measures for patients with flat feet during running.
Petrographic Characterisation and Paleoenvironmental Reconstruction of the Kipala Shales (Central Basin, DRC, Kwilu Province)
Authors: Munene Djonive , Kanika Mayena Thomas , Kimbungu Etumba Elie , Makutu Mangwayaya Adalbert-Jules , Dominique Wetshondo Osomba , Nakasila Kinakow Jules , Katakanga N’kembo Audrey , Kabama Kasombo Napoleon , Koy Kasongo Ruben
Published: October 2024

In order to fill the glaring gaps in geological data for the Kipala region, in the Kwilu province of the Democratic Republic of Congo, geological studies were carried out. The results identified four different lithofacies in the study area: dark greasy shale, feldspathic microgres, clayey sandstone and bituminous shale. The petrographic compositions and palaeoenvironmental conditions of the deposit are presented for the first time in this work. From a petrographic point of view, the rock samples analysed differ in the nature of their constituent minerals and/or matrix or cement. Similarly, there is a close relationship between local lake and river sediments. The size and degree of rounding of the clayey sandstones in the rocks studied suggest that they were transported over a long period under strong hydrodynamic conditions.
Cancer Risks in Attenuated and Classical Familial Adenomatous Polyposis: A Nationwide Cohort With Matched, Nonexposed Individuals
Authors: Beck Søren Hammershøj , Karstensen John Gásdal , Bülow Steffen , Andersen Klaus Kaae , Hansen Thomas van Overeem , Højen Helle , Jespersen Niels , Kuhlmann Tine Plato , Pommergaard Hans Christian , Wewer Mads Damsgaard , Wullum Laus , Jelsig Anne Marie , Burisch Johan
Published: October 2024

INTRODUCTION:

Familial adenomatous polyposis (FAP) is caused by pathogenic variants in the APC gene. FAP is usually categorized according to phenotype: classical FAP (CFAP) and attenuated FAP (AFAP); the latter is considered to have a milder disease course. We aimed to assess the risk of overall and specific cancers in patients with CFAP and AFAP compared with matched, nonexposed individuals.

METHODS:

All known Danish patients with FAP were classified as either CFAP or AFAP and assigned 4 matched, nonexposed individuals. The risk of overall and specific cancers, and mortality were analyzed.

RESULTS:

The analysis included 311 patients with CFAP, 134 patients with AFAP, and 1,600 nonexposed individuals. The overall cancer risk was significantly higher for both patients with CFAP and AFAP than for nonexposed individuals, with hazard ratios (HRs) of 4.77 (95% confidence interval [CI], 3.61–6.32; P < 0.001) for CFAP and 3.22 (95% CI, 2.16–4.80; P < 0.001) for AFAP. No significant difference was observed when comparing CFAP and AFAP (HR = 1.48; 95% CI, 0.98–2.25; P = 0.0646). The HR of colonic cancer was 2.16 (95% CI, 0.99–7.72; P = 0.0522) and 2.72 (95% CI, 1.19–6.22; P = 0.0177 for CFAP and AFAP), respectively, compared with nonexposed and did not differ between patients with CFAP and AFAP (HR = 0.80; 95% CI, 0.32–2.00; P = 0.6278). Mortality was significantly higher in CFAP (HR = 2.96; 95% CI, 2.04–4.28; P < 0.001), but not in AFAP (HR = 1.40; 95% CI, 0.73–2.69; P = 0.311).

DISCUSSION:

Nationwide data reveal differing risk profiles for specific cancers and mortality in AFAP and CFAP compared with nonexposed individuals. The cancer burden of AFAP necessitates consistent monitoring of these patients.
THE IMPLEMENTATION OF INTELLECTUAL PROPERTY DISPUTE RESOLUTION THROUGH MEDIATION & ARBITRATION
Authors: Sidik Jafar , Rozali Asep , Sulistianingsih Dewi
Published: October 2024

This article aims at determining, describing, and analyzing the application of intellectual property rights through mediation & arbitration from the perspective of Indonesian law and its practice in the Arbitration Regulations of the Indonesian National Arbitration Board. Intellectual Property dispute resolution among the disputing parties by mediation and arbitration (out-of-state court settlement) has not been effective because of limited and lack of socialization from the Government or mediation and arbitration institution. The resolution of IPR disputes has not been effective, this is evident from the results of discussions with the DJKI and the West Java Kanwilkumham, which are still few IPR cases that have been registered to be resolved. Likewise, very few IPR cases have been submitted to the Dispute Resolution Institution.
PERAN PENDAMPING PEKERJA MIGRAN PEREMPUAN DALAM MENCEGAH TINDAK PIDANA PERDAGANGAN ORANG DI KABUPATEN KENDAL
Authors: Khasanah Dian Ratu Ayu Uswatun , Rizkiana Rina Elsa , Khanifa Nurma Khusna , Pongantung Ronald Jolly , Muzammil Moh.
Published: October 2024

Praktik Tindak Pidana Perdagangan Orang (TTPO) merupakan salah satu kasus migran yang terjadi di Kabupaten Kendal. Pendamping migran menjadi jembatan dalam memberikan pendampingan bagi pekerja migran perempuan. Metode yang digunakan dalam penelitian ini adalah metode pendekatan yuridis empiris dengan didukung data primer melalui wawancara secara mendalam dengan pendamping dan calon pekerja migran maupun mantan pekerja migran di Kabupaten Kendal. Hasil penelitian ini menunjukkan bahwa peran pendamping pekerja migran dilakukan secara mandiri dan sukarela dalam menagani masalah para pekerja migran perempuan. Dengan memberikan pendampingan kepada para pekerja migran perempuan dan keluarganya yang mengalami masalah pada saat bekerja dan setelah bekerja di luar negeri dengan memberikan pendidikan kritis, memberikan pemberdayaan ekonomi, memberikan pelatihan bagi yang sudah kembali ke Indonesia.
Spatial analysis of ecological risk in a coastal dune landscape using high resolution aerial photography
Authors: ListyaNiNgrum Noviyanti , Mardiatno Djati , Pangaribowo Evita Hanie , Setiawan Muhammad Anggri , Sartohadi Junun , Sulistyo Bambang
Published: October 2024

This study aims to investigate the dynamic pattern of landscape ecological units (LEUs) and analyse spatial variations of the ecological risk in Parangtritis coastal dune, Yogyakarta, Indonesia. A quantitative method was used in this research as part of landscape ecological analysis using a geographic information system. LEUs were interpreted by small format aerial photographs (SFAPs) and verified through field survey, then were calculated using the formula within grids to produce the ecological risk index (ERI) in the total area. According to the sub-class and class scenario, many LEUs showed changes in their landscape pattern. The ERI in the study area consisted of five levels (very low to very high), each of which was spatially varied. The ecological risk formed clusters coinciding with certain LEUs where fragility chiefly contributed to the sub-class scenario, while disturbance contributed to the class scenario.
Progress in Arctic coastal geomorphological research in times of rapid climate warming
Authors: Owczarek Zofia , Stachowska-Kamińska Zofia , Kostrzewa Oskar , Szczypińska Małgorzata
Published: October 2024

Recognising the degree of climate transformations in the Arctic becomes vital, especially in times of rapid global climate change. The 21st century has seen a renaissance in Arctic coastal research. Here, we aim to present this recent progress. Moving from the European Arctic through the Siberian part and ending with the Canadian Arctic Archipelago (CAA), we describe how the region’s coasts have transformed. This work is mostly focussed on progress in coastal geomorphology, geohazards, and reconstructions of the paleoarchives, although we also address the future research challenges of cold region coastal environments.
Application of remote-sensing data in geochemical studies of soils of the Yertis River basin within East Kazakhstan
Authors: Ulykpanova Meruyert M. , Auezova Zaure , Ramazanova Nurgul , Mussabaeva Meruert , Zhanguzhina Altyn
Published: October 2024

This article presents the results of field research, as well as the results of the use of remote-sensing data in the geochemical study of the soil cover of the Yertis River basin. In the work, the content of the gross form of heavy metals in the soil of the river basin was investigated. The atomic absorption method determined the content of the Poor configuration of elements of elements in soils. Statistical processing of the obtained data from N. A. Plokhinsky was carried out using the Statistica program. Also, using the performed indices in the remote sensing of clay minerals, iron oxides, and carbonates, the spatial distribution and comparison of pollutants in the soil cover of the river basin were revealed. The methods and means of image processing tested in this study can be used to create maps of the distribution of pollutants. Also, the data obtained reflect the patterns of distribution of heavy metals in the soils of the basin and can be used to optimize landscapes and improve the organization of ecological and geochemical monitoring.
Social and geographical distribution of mobility-related greenhouse gas emissions in Poznań and Tri-city functional urban areas
Authors: Czepkiewicz Michał , Brudka Cezary , Krysiński Dawid , Schmidt Filip
Published: October 2024

Mobility is an important source of greenhouse gas (GHG) emissions and a major contributor to human-induced climate change. Much of these emissions result from urban residents’ travel within urban areas (i.e. short-distance travel [SDT]) and away from them (i.e. long-distance travel [LDT]). In this study, we focus on the distribution of mobility-related GHG emissions in two functional urban areas in Poland: Poznań and the Tri-city. Using data from a representative survey (N ~2000 in each area), we investigate the emission distribution and associations between emission levels and the socio-economic characteristics and residential locations of study participants. Emission levels are unequally distributed: the top 10% of emitters contribute >50% of SDT and LDT emissions. People with high education and income levels tend to travel and emit more within and away from the cities. People of retirement age travel and emit much less than the younger people. SDT emission levels are clustered spatially and increase with the increasing distance from the main city centres and decreasing density. LDT emissions have only very weak or no association with residential location.