bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Inulin-Mediated Ethanol Precipitation Method for Separating Endo-Inulinase From Inulinases for Inulooligosaccharides Production From Inulin
Authors: Li Xin , Zhang Qiannan , Wang Wei , Yang Shang-Tian
Published: April 2021

Inulin is a kind of polysaccharide that can be obtained various biomass. Inulooligosaccharides (IOS), a kind of oligosaccharides that can be obtained from inulin by enzymatic hydrolysis using inulinases, have been regarded as the functional food ingredients. Commercially available inulinases produced by natural Aspergillus niger contained both endo- and exo-inulinase activities. For IOS production from inulin, it is desirable to use only endo-inulinase as exo-inulinase would produce mainly the monosacchairde fructose from inulin. In the present study, a simple inulin-mediated ethanol precipitation method was developed to separate endo- and exo-inulinases present in natural inulinases. IOS production from inulin using the enriched endo-inulinase was then optimized in process conditions including pH and temperature, achieving a high yield of ∼94%. The resultant IOS products had a degree of polymerization ranging from 2 to 7. The study demonstrated a novel method for obtaining partially purified or enriched endo-inulinase for IOS production from inulin in an efficient process.
Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer
Authors: Takeiwa Toshihiko , Ikeda Kazuhiro , Horie-Inoue Kuniko , Inoue Satoshi
Published: April 2021

Ovarian cancer is a health-threatening malignancy of ovary in female reproductive systems and one of the most common gynecological malignancies worldwide. Due to rare early symptoms, ovarian cancers are often diagnosed at advanced stages and exhibit poor prognosis. Thus, efforts have been paid to develop alternative diagnostic and therapeutic strategies for the disease. Recent studies have presented that some long non-coding RNAs (lncRNAs) play roles in apoptosis of ovarian cancer cells through various mechanisms involved in the regulation of transcription factors, histone modification complexes, miRNAs, and protein stability. Because evasion of apoptosis in cancer cells facilitates to promote tumor progression and therapy resistance, apoptosis regulatory mechanisms of lncRNAs may be promising new targets in ovarian cancer. In this review, we introduce the recent findings in regard to the molecular mechanisms of apoptosis-related lncRNAs in ovarian cancer cells.
Probing Biosensing Interfaces With Single Molecule Localization Microscopy (SMLM)
Authors: Cheng Xiaoyu , Yin Wei
Published: April 2021

Far field single molecule localization microscopy (SMLM) has been established as a powerful tool to study biological structures with resolution far below the diffraction limit of conventional light microscopy. In recent years, the applications of SMLM have reached beyond traditional cellular imaging. Nanostructured interfaces are enriched with information that determines their function, playing key roles in applications such as chemical catalysis and biological sensing. SMLM enables detailed study of interfaces at an individual molecular level, allowing measurements of reaction kinetics, and detection of rare events not accessible to ensemble measurements. This paper provides an update to the progress made to the use of SMLM in characterizing nanostructured biointerfaces, focusing on practical aspects, recent advances, and emerging opportunities from an analytical chemistry perspective.
Detecting Group Anomalies in Tera-Scale Multi-Aspect Data via Dense-Subtensor Mining
Authors: Shin Kijung , Hooi Bryan , Kim Jisu , Faloutsos Christos
Published: April 2021

How can we detect fraudulent lockstep behavior in large-scale multi-aspect data (i.e., tensors)? Can we detect it when data are too large to fit in memory or even on a disk? Past studies have shown that dense subtensors in real-world tensors (e.g., social media, Wikipedia, TCP dumps, etc.) signal anomalous or fraudulent behavior such as retweet boosting, bot activities, and network attacks. Thus, various approaches, including tensor decomposition and search, have been proposed for detecting dense subtensors rapidly and accurately. However, existing methods suffer from low accuracy, or they assume that tensors are small enough to fit in main memory, which is unrealistic in many real-world applications such as social media and web. To overcome these limitations, we propose D-Cube, a disk-based dense-subtensor detection method, which also can run in a distributed manner across multiple machines. Compared to state-of-the-art methods, D-Cube is (1) Memory Efficient: requires up to 1,561× less memory and handles 1,000× larger data (2.6TB), (2) Fast: up to 7× faster due to its near-linear scalability, (3) Provably Accurate: gives a guarantee on the densities of the detected subtensors, and (4) Effective: spotted network attacks from TCP dumps and synchronized behavior in rating data most accurately.
Mainstreaming Ecosystem Services and Biodiversity in Peri-Urban Forest Park Creation: Experience From Eastern Europe
Authors: Sevianu Eliana , Maloş Cristian Valeriu , Arghiuş Viorel , Brişan Nicoleta , Bǎdǎrǎu Alexandru Sabin , Moga Marius Cǎtǎlin , Muntean Liviu , Rǎulea Adrian , Hartel Tibor
Published: April 2021

The social role of peri-urban forests is diversifying, and this implies that peri-urban forests are redesigned to meet and shape social demands. A key challenge is the integration of the social demands for green spaces with the maintenance of key ecosystem structures and processes as well as the biodiversity of the green spaces. In this study, we report our experience and insights gathered through the implementation of a project targeting a peri-urban forest development near the city of Cluj-Napoca. One key particularity of the project was that it was designed by the city hall in cooperation with a major NGO, and the academic sector joined the project in its second stage, with the aim of mainstreaming ecosystem services and biodiversity within a well-established design concept. After comprehensively assessing the biodiversity and ecosystem services of the targeted forest, we found that the ecosystem supply was strongly related to the tree stand structure and the forestry management from the past decades. The public expressed concerns related to the parts of the established development design, which included built structures, artificial lights, toilets, and paved roads, perceiving that these actions will negatively influence the natural environment. We present the modifications undertaken in the project design after the public consultation and deliberation within the implementation team. An anonymous internal evaluation of the implementation team shows appreciation for the human and professional interactions and the resulting innovation and learning opportunities. To improve interdisciplinary collaborations, there is a need for a good institutional support and financial reward, transparency, and good communication within the team. At the end of the “Discussion” section, we present the insights gathered from this interdisciplinary experience in order to guide further similar projects in Central and Eastern Europe.
Enabling Genomics Pipelines in Commodity Personal Computers With Flash Storage
Authors: Cadenelli Nicola , Jun Sang-Woo , Polo Jordà , Wright Andrew , Carrera David , Arvind
Published: April 2021

Analysis of a patient's genomics data is the first step toward precision medicine. Such analyses are performed on expensive enterprise-class server machines because input data sets are large, and the intermediate data structures are even larger (TB-size) and require random accesses. We present a general method to perform a specific genomics problem, mutation detection, on a cheap commodity personal computer (PC) with a small amount of DRAM. We construct and access large histograms of k-mers efficiently on external storage (SSDs) and apply our technique to a state-of-the-art reference-free genomics algorithm, SMUFIN, to create SMUFIN-F. We show that on two PCs, SMUFIN-F can achieve the same throughput at only one third (36%) the hardware cost and half (45%) the energy compared to SMUFIN on an enterprise-class server. To the best of our knowledge, SMUFIN-F is the first reference-free system that can detect somatic mutations on commodity PCs for whole human genomes. We believe our technique should apply to other k-mer or n-gram-based algorithms.
Induction of IL-9 in Peripheral Lymphocytes of Rheumatoid Arthritis Patients and Healthy Donors by Th17-Inducing Cytokine Conditions
Authors: Heim Jana , Almanzar Giovanni , Schmalzing Marc , Gernert Michael , Tony Hans-Peter , Prelog Martina
Published: April 2021

IL-9-producing Th9 cells display a group of helper T cells with similarities to Th17 and Th2 T cells and have been shown to be involved in synovial inflammation in rheumatoid arthritis (RA) patients. So far, it is unclear which parameters drive Th9 differentiation in lymphocytes derived from RA patients compared to immunologically healthy individuals and whether autocrine mechanisms are able to enhance Th9 polarization. Further, parallel pathways of induction of IL-17-producing cells with Th9 phenotype have to be distinguished from exclusively Th9-inductive mechanisms. Thus, the present study aimed to determine the parameters of Th9 induction by simulation in a standardized inflammatory cytokine milieu.Peripheral naive and non-naive T cells of RA patients and healthy donors (HD) were cultured under Th9 and Th17-driving conditions and phenotypically analyzed by flow cytometry and molecular analysis.Our findings indicate a similar differentiation pathway of Th9 and Th17 cells and similar distributions of IL-9+ T cells in RA and HD regardless of Th9- or Th17-promoting cytokine milieus. Whereas the magnitude and direction of Th9- or Th17-polarization was about the same in RA and HD, IL-17+ CD4+ T cells were significantly stimulated by Th17-inducing conditions in HD. In conclusion, the results indicate that Th9- and Th17-inducing cytokine conditions mimicking autoimmune inflammation in RA may have similar stimulatory effects regarding polarization of peripheral naive and non-naive T cells into Th9 or Th17 cells. The results suggest that the differentiation of Th9 cells may be also induced by Th17-driving conditions.
Glioma-Associated Stromal Cells Stimulate Glioma Malignancy by Regulating the Tumor Immune Microenvironment
Authors: Cai Xiangming , Yuan Feng , Zhu Junhao , Yang Jin , Tang Chao , Cong Zixiang , Ma Chiyuan
Published: April 2021

Background

The glioma-associated stromal cell (GASC) is a recently identified type of cell in the glioma microenvironment and may be a prognostic marker for glioma. However, the potential mechanisms of GASCs in the glioma microenvironment remain largely unknown. In this work, we aimed to explore the mechanisms of GASCs in gliomas, particularly in high-grade gliomas (HGG).

Methods

We used glioma datasets from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA). We utilized the Single-sample Gene Set Enrichment Analysis (ssGSEA) algorithm to discriminate between patients with high or low GASC composition. The xCELL and CIBERSORT algorithms were used to analyze the composition of stromal cells and immune cells. Risk score and a nomogram model were constructed for prognostic prediction of glioma.

Results

We observed for the first time that the levels of M2 macrophages and immune checkpoints (PD-1, PD-L1, PD-L2, TIM3, Galectin-9, CTLA-4, CD80, CD86, CD155, and CIITA) were significantly higher in the high GASC group and showed positive correlation with the GASC score in all glioma population and the HGG population. Copy number variations of DR3 and CIITA were higher in the high-GASC group. THY1, one of the GASC markers, exhibited lower methylation in the high GASC group. The constructed risk score was an independent predictor of glioma prognostics. Finally, a credible nomogram based on the risk score was established.

Conclusions

GASCs stimulate glioma malignancy through the M2 macrophage, and are associated with the level of immune checkpoints in the glioma microenvironment. The methylation of THY1 could be used as prognostic indicator and treatment target for glioma. However, further studies are required to verify these findings.
Phosphoproteomic Profiling of Rat’s Dorsal Root Ganglia Reveals mTOR as a Potential Target in Bone Cancer Pain and Electro-Acupuncture’s Analgesia
Authors: Wang Wen , Zhou You , Cai Yangqian , Wang Sisi , Shao Fangbing , Du Junying , Fang Junfan , Liu Jinggen , Shao Xiaomei , Liu Boyi , Fang Jianqiao , Liang Yi
Published: April 2021

Bone cancer pain (BCP) is a clinical refractory mixed pain involving neuropathic and inflammatory pain, with the underlying mechanisms remaining largely unknown. Electro-acupuncture (EA) can partly alleviate BCP according to previous research. We aim to explore the proteins and major pathways involved in BCP and EA treatment through phosphoproteomic profiling. BCP rat model was built by tibial inoculation of MRMT-1 mammary gland carcinoma cells. Mechanical hyperalgesia determined by paw withdrawal thresholds (PWTs) and bone destruction manifested on the radiographs confirmed the success of modeling, which were attenuated by EA treatment. The differentially expressed phosphorylated proteins (DEPs) co-regulated by BCP modeling and EA treatment in rat dorsal root ganglions (DRGs) were analyzed through PEX100 Protein microarray. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that DEPs were significantly enriched in mammalian target of rapamycin (mTOR) signaling pathway. The phosphorylations of mTOR at Ser2448 and Thr2446 were increased in BCP and downregulated by EA. In addition, the phosphorylation of S6K and Akt, markers of the mTOR complex, were also increased in BCP and downregulated by EA. Inhibition of mTOR signaling alleviated the PWTs of BCP rats, while the mTOR agonist impaired the analgesic effect of EA. Thus, our study provided a landscape of protein phosphorylation changes in DRGs of EA-treated BCP rats and revealed that mTOR signaling can be potentially targeted to alleviate BCP by EA treatment.
Evaluation of the Efficacy and Safety of Chinese Herbal Injection Combined With Trimetazidine for Viral Myocarditis: A Network Meta-Analysis
Authors: Wu Kerui , Deng Dingwei , Yu Binghui , Han Ziyun , Huang Lanlin , He Yaxing , Yan Xia , Wang Dawei
Published: April 2021

Background: Viral myocarditis (VMC) is a common emergency of cardiovascular disease. Current treatment for VMC includes the prohibition of exercise plus supportive and symptomatic treatment, given the lack of specific antiviral therapeutic options and insufficient evidence for the use of novel immunosuppressive therapies. Trimetazidine, a drug used to improve myocardial energy metabolism, is frequently used for the treatment of viral myocarditis. In China, Chinese herbal injections (CHIs) are often used in combination with trimetazidine. Therefore, we evaluate the efficacy and safety of CHI combined with trimetazidine in the treatment of VMC through the method of network meta-analysis.

Methods: We searched PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, Chinese Scientific Journals Full-text Database (VIP), and China Biology Medicine Database (CBM) databases from inception to September 1, 2020, to identify eligible randomized controlled trials. The Cochrane risk of bias tool was used to assess the risk of bias among selected studies and the Stata 16.0 software was used to perform the network meta-analysis.

Results: A total of 29 studies were included, representing data from 2,687 patients. The effectiveness rate, level of myocardial injury marker, and the adverse reaction rate were evaluated. Compared with conventional treatment or conventional treatment combined with trimetazidine, CHIs combined with trimetazidine appeared to have a better therapeutic effect, with higher effectiveness rate and better reduction of the levels of creatine kinase, creatine kinase-MB, and lactate dehydrogenase. Based on surface under the cumulative ranking, Shenmai injection combined with trimetazidine appeared to be superior in terms of effective rate, while Astragalus injection or Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with trimetazidine appeared most effective in reducing myocardial injury markers. There was no significant difference in safety between the interventions. However, a lack of safety monitoring in some selected studies meant that the safety of some interventions could not be fully evaluated.

Conclusion: CHIs combined with trimetazidine may have therapeutic value in the treatment of viral myocarditis, and Shenmai injection, Astragalus injection, and Salviae miltiorrhizae and ligustrazine hydrochloride injection may represent the most effective CHIs. Further clinical investigation is required to confirm these results.
A Cross-Sectional Study Investigating the Relationship Between Alexithymia and Suicide, Violence, and Dual Harm in Male Prisoners
Authors: Hemming Laura , Shaw Jennifer , Haddock Gillian , Carter Lesley-Anne , Pratt Daniel
Published: April 2021

Background: Suicide and violence are common within male prisoners. One suggested risk factor for both behaviors is alexithymia. Alexithymia describes a deficit in identifying and describing feelings and is also related to externally oriented thinking. This study aimed to explore the relationship between alexithymia, suicide, violence and dual harm in male prisoners.

Methods: Eighty male prisoners were recruited from three prisons. Participants were asked to complete a battery of questionnaires including measures of alexithymia (TAS-20), suicide ideation (ASIQ), suicide behavior, violence ideation (SIV), violence behavior, depression (BDI-II), hopelessness (BHS), impulsivity (DII) and anger (NAS-PI). Regression analyses and ANOVAS were conducted to assess the association between alexithymia (and its subcomponents) with six outcomes; suicide ideation, suicide behavior, violence ideation, violence behavior, dual harm ideation and dual harm behavior.

Results: Alexithymia was a univariate predictor of suicide ideation, though was not a significant predictor when considered in a multivariate model. Alexithymia was a significant multivariate predictor of suicide behavior. Alexithymia was not a significant multivariate predictor of violence ideation or behavior. There were no significant differences in alexithymia or subscales between those with suicide ideation/behavior alone, violence ideation/behavior alone and those with dual harm ideation/behavior.

Conclusion: In male prisoners, alexithymia appears an important univariate predictor of suicide and violence, though the current study suggests no significant contribution above other well-known correlates of suicide and violence.
Probability Representation of Quantum States
Authors: Man’ko Olga V. , Man’ko Vladimir I.
Published: April 2021

The review of new formulation of conventional quantum mechanics where the quantum states are identified with probability distributions is presented. The invertible map of density operators and wave functions onto the probability distributions describing the quantum states in quantum mechanics is constructed both for systems with continuous variables and systems with discrete variables by using the Born’s rule and recently suggested method of dequantizer–quantizer operators. Examples of discussed probability representations of qubits (spin-1/2, two-level atoms), harmonic oscillator and free particle are studied in detail. Schrödinger and von Neumann equations, as well as equations for the evolution of open systems, are written in the form of linear classical–like equations for the probability distributions determining the quantum system states. Relations to phase–space representation of quantum states (Wigner functions) with quantum tomography and classical mechanics are elucidated.
Seven Ways a Warming Climate Can Kill the Southern Boreal Forest
Authors: Frelich Lee E. , Montgomery Rebecca A. , Reich Peter B.
Published: April 2021

The southern boreal forests of North America are susceptible to large changes in composition as temperate forests or grasslands may replace them as the climate warms. A number of mechanisms for this have been shown to occur in recent years: (1) Gradual replacement of boreal trees by temperate trees through gap dynamics; (2) Sudden replacement of boreal overstory trees after gradual understory invasion by temperate tree species; (3) Trophic cascades causing delayed invasion by temperate species, followed by moderately sudden change from boreal to temperate forest; (4) Wind and/or hail storms removing large swaths of boreal forest and suddenly releasing temperate understory trees; (4) Compound disturbances: wind and fire combination; (5) Long, warm summers and increased drought stress; (6) Insect infestation due to lack of extreme winter cold; (7) Phenological disturbance, due to early springs, that has the potential to kill enormous swaths of coniferous boreal forest within a few years. Although most models project gradual change from boreal forest to temperate forest or savanna, most of these mechanisms have the capability to transform large swaths (size range tens to millions of square kilometers) of boreal forest to other vegetation types during the 21st century. Therefore, many surprises are likely to occur in the southern boreal forest over the next century, with major impacts on forest productivity, ecosystem services, and wildlife habitat.
Prenatal Ultrasound Suspicion of Cystic Fibrosis in a Multiethnic Population: Is Extensive CFTR Genotyping Needed?
Authors: Mekki Chadia , Aissat Abdel , Mirlesse Véronique , Mayer Lacrosniere Sophie , Eche Elsa , Le Floch Annick , Whalen Sandra , Prud’Homme Cecile , Remus Christelle , Funalot Benoit , Castaigne Vanina , Fanen Pascale , de Becdelièvre Alix
Published: April 2021

In families without a Cystic Fibrosis (CF) history, fetal ultrasound bowel abnormalities can unexpectedly reveal the disease. Isolated or in association, the signs can be fetal bowel hyperechogenicity, intestinal loop dilatation and non-visualization of fetal gallbladder. In these cases, search for CF transmembrane conductance regulator (CFTR) gene mutations is part of the recommended diagnostic practices, with a search for frequent mutations according to ethnicity, and, in case of the triad of signs, with an exhaustive study of the gene. However, the molecular diagnosis remains a challenge in populations without well-known frequent pathogenic variants. We present a multiethnic cohort of 108 pregnancies with fetal bowel abnormalities in which the parents benefited from an exhaustive study of the CFTR gene. We describe the new homozygous p.Cys1410* mutation in a fetus of African origin. We did not observe the most frequent p.Phe508del mutation in our cohort but evidenced variants undetected by our frequent mutations kit. Thanks to the progress of sequencing techniques and despite the difficulties of interpretation occasionally encountered, we discuss the need to carry out a comprehensive CFTR study in all patients in case of fetal bowel abnormalities.
Applied Big Data Analysis to Build Customer Product Recommendation Model
Authors: Lin Rong-Ho. , Chuang Wei-Wei , Chuang Chun-Ling , Chang Wan-Sin
Published: April 2021

With the development of the Internet environment, the trend of the retail industry in the future. It cannot be separated from the community, data and experience. Consumers’ lifestyles and purchasing behaviors are constantly changing and retailers must adopt policies to understand consumers. This research analyzes supermarkets most commonly touched by consumers in daily life. In order to find hidden information behind customer transaction data, it helps supermarkets to learn about the habits of customers to help them Formulate marketing strategies and improve the profitability of supermarkets and maintain long-term relationships with customers. Thus, the RFM model is used to convert customer transaction data into R, F, and M values and then clustering using the Ward’s method to combine with K-means, fuzzy C-means, and self-organizing maps. Using discriminant analysis find out the grouping method with the highest accuracy rate to calculate the customer lifetime value score. In terms of product recommendation, customers can be recommended to buy products in the top five categories or to use rules found in association rule to make recommendations. In terms of customers, we maintain long-term relationships with customers by recommending other related products, products for bundling sale, giving gifts or discount coupons, and regularly organizing promotional activities.
Perspectives on Non-BLT Humanized Mouse Models for Studying HIV Pathogenesis and Therapy
Authors: Terahara Kazutaka , Iwabuchi Ryutaro , Tsunetsugu-Yokota Yasuko
Published: April 2021

A variety of humanized mice, which are reconstituted only with human hematopoietic stem cells (HSC) or with fetal thymus and HSCs, have been developed and widely utilized as in vivo animal models of HIV-1 infection. The models represent some aspects of HIV-mediated pathogenesis in humans and are useful for the evaluation of therapeutic regimens. However, there are several limitations in these models, including their incomplete immune responses and poor distribution of human cells to the secondary lymphoid tissues. These limitations are common in many humanized mouse models and are critical issues that need to be addressed. As distinct defects exist in each model, we need to be cautious about the experimental design and interpretation of the outcomes obtained using humanized mice. Considering this point, we mainly characterize the current conventional humanized mouse reconstituted only with HSCs and describe past achievements in this area, as well as the potential contributions of the humanized mouse models for the study of HIV pathogenesis and therapy. We also discuss the use of various technologies to solve the current problems. Humanized mice will contribute not only to the pre-clinical evaluation of anti-HIV regimens, but also to a deeper understanding of basic aspects of HIV biology.
Innovative approaches to health care planning in a multidisciplinary hospital
Authors: Sobolev Konstantin Eduardovich , Pirogov Mikhail Vasilyevich
Published: April 2021

The article examines new organizational and economic decisions on the planning of inpatient care within the framework of the territorial program of compulsory health insurance. The peculiarities of the multi-disciplinary hospital, which provides medical care not only to patients living in close proximity to the medical organization, but also to non-resident patients are taken into account. The main group characteristics of hospitals and the specifics of the formation of the number of hospitalizations for them have been determined.
Jacob Boehme’s etymology: eschatological and epistemic aspects
Authors: Karabykov A.
Published: April 2021

The aim of the study is to analyze an etymological practice of the great German mystic thinker and to determine its place in his esoteric doctrine. The essence and cause of utter idiosyncrasy of that practice along with its yet not examined typical aspect are considered. It is argued the latter linked Boehme’s linguo-philosophic speculations with relevant construct of positively oriented ‘secular’ scholars whose best part laid the foundation for the comparativism.
Theory and history of traditional applied art. Didactic materials for self-extracurricular work of students
Authors: Kurakina I.
Published: April 2021

Reference book is addressed to students studying the theory and history of traditional applied art. It is a set of materials for self-extracurricular work. There are of the questions and tasks for research, artistic and creative activities, information and reference materials, dictionaries and references. The presented theoretical and practical material reveals the main aspects of the existence of traditional applied art in Russia, the logic of development, successive artistic and stylistic features of the language of its specific types.
Ethics in the secular and religious life of man
Authors: Panyshev A.
Published: April 2021

This paper is devoted to the study of ethics in the context of secular and religious life. The article postulates that religious ethics is addressed to the spiritual world of a person for whom the criteria of moral development are constant. Within the limits of secular ethics the norms of morality are dictated by public moods and fashion at a certain time period. An important feature of religious ethics is its appeal to faith in God, and therefore it is designed to promote the spiritual salvation of man. Secular ethics is focused on the socialization of the individual in the team and ensuring his physical security. Modern society proclaims the freedom of man in choosing between secular and religious ethics, however, social realities and features of the information space predispose people to focus on secular ethics. Of particular importance here is the Russian Orthodox Church, it is important to avoid participation in the political struggle between various secular parties that do not enjoy authority in the eyes of society.
On the mechanism of the impact of paintings on the lumbosacral joint
Authors: Benditsky I. , Shestakov V. , Shestakov D.
Published: April 2021

Current article elaborates on the mechanism of the influence of cultural value on patient’s consciousness, which causes to restore normal functions of the spine and sacrum-lumbar region. A non-invasive method to relieve spastics was developed, basing on the practice of application of the archetypical images to remove emotional blockade that is caused to the nervous system by informational impact. Authors prove presence of the effect from cultural value on consciousness of the patient. Effect is established as an electromagnetic interaction between the patient and the cultural field of the painting. Article describes the algorithm of such influence and mechanism of verification of art works suitable for the prevention of affliction symptoms. The results of this research could be applied for treatment and prevention of various sacrum related ailments, post-surgery rehabilitation and drug treatment. Studies propose a new art direction — sacral realism, while establishing objective criteria for assessing the relation of art works in this new genre.
Obstetrics literature. About translation experience
Authors: Hofman T.
Published: April 2021

The following article tackles the question of translating as a transformation on several levels: of the language use; of the translater who is a medium; the reader and, last but not least, the author who receives a mirror of his original text. This idea I explain referring to my own experience as a translater from Russian to German, parcularly the Book of Food by Igor Klekh. My argument contradicts Walter Benjamin as I plead for a conscious involvement of the reader’s horizont and a careful treatful of the original text, except we deal with poetry. Else even prose might be transformed into poetry.
Scientific approaches to the analysis of problems of citizenship and patriotism in modern humanitarian discourse
Authors: Drobizheva-Razumovskaya L. , Lisenkova A. , Pismanik M.
Published: April 2021

The paper analyzes the vectors of development of the strategy of the state national and cultural policy of the Russian Federation in the last decade (2009–2019), presented in the materials of the plenary and sectional reports of the participants of the all-Russian scientific and practical conference “Cultural, religious and moral problems of formation of citizenship” of the Perm state Institute of culture. Since 2009, the Institute has organized twelve all-Russian scientific and practical conferences and round tables with the participation of leading Russian scientists-humanitarians who have made a great contribution to understanding and forecasting possible risks and opening prospects related to topical issues of implementing the national strategy of civil unity and inter-confessional interaction. Every year, based on the results of round tables and plenary sessions, the organizing Committee develops a package of proposals for optimizing and improving the effectiveness of the measures presented in the strategy, which is sent to state authorities and public organizations. This paper presents a wide range of topics that were reflected in the last conference, focusing on the understanding of cultural, religious and moral issues related to the formation of citizenship of Russians.
Estrategias financieras para la eficiencia de las operaciones en departamento de finanzas
Authors: Aguilar José , León Alfonso , Núñez Dayana
Published: April 2021

El presente estudio tiene como propósito conocer, identificar y evaluar los procedimientos y estrategias financieras aplicadas en el departamento de finanzas de la empresa Febeca, C.A. El estudio se enmarcó dentro de un diseño metodológico no experimental transaccional, del tipo de investigación de campo, con un nivel descriptivo. Se pudo concluir que la empresa objeto de estudio carecía de un proceso de planificación financiera sólido y enfoques orientados a la eficiencia de las operaciones y capacidades internas y externas, para una buena administración y ejecución de sus estrategias financieras dirigidas a la sostenibilidad y crecimiento, lo cual la coloca en situación de riesgo frente a las condiciones políticas, sociales y económicas del país. Partiendo de esta perspectiva se recomendaron una serie de acciones para el desarrollo de las estrategias y garantizar la eficiencia, sostenibilidad y crecimiento de la empresa.

ABSTRACT

The purpose of this study is to know, identify and evaluate the procedures and financial strategies applied in the finance department of the company Febeca, C.A. The study was framed within a non-experimental transactional methodological design, of the field research type, with a descriptive level. It was concluded that the company under study lacked a solid financial planning process and approaches oriented to the efficiency of operations and internal and external capacities, for a good administration and execution of its financial strategies aimed at sustainability and growth, which places it at risk from the political, social and economic conditions of the country. Based on this perspective, a series of actions were recommended for the development of strategies and guarantee the efficiency, sustainability and growth of the company.
Análise da Metodologia SOESGOPE em malha fechada para a Estimação Ótima de Parâmetros de um quadrotor
Authors:   , Gonçalves Pablo Henrique
Published: April 2021

Existem diversos métodos de Estimação Ótima de Parâmetros. Em identificação de sistemas é necessário um sinal de excitação rico, que excite suficientemente o sistema. Se a relação entrada/saída não for capaz de gerar informação suficiente, qualquer técnica de Estimação Ótima de Parâmetros (OPE) falhará. O processo de identificação de sistemas em malha fechada é fundamental para situações em que a planta possui não linearidades e comportamentos que são difíceis de prever e com estabilidade não garantida para malha aberta. Este trabalho apresenta uma análise da metodologia SOESGOPE para a estimação dos parâmetros de um sistema em malha fechada e a geração de sinal de excitação para o experimento. Para a identificação de sistemas não lineares em malha fechada é necessário um controlador simples que mantenha o sistema estável e que permita a passagem de frequências que sensibilizem adequadamente o sistema. A metodologia SOESGOPE é responsável pela busca de um sinal de excitação para o experimento que seja compatível com o controlador, de modo que a excitação do sinal fornecido seja suficiente para estimar os parâmetros. Para os casos em que as incertezas sobre os parâmetros dificultam o projeto do controlador, foi proposta uma nova abordagem da metodologia, visando sintonizar um controlador simples e eficiente para a estimação de parâmetros. A nova abordagem proposta busca, a partir do processo de otimização em duas camadas, um conjunto de controladores para manter o sistema estável e que seja compatível com o sinal de excitação para o processo de estimação de parâmetros. A nova abordagem da metodologia SOESGOPE apresenta resultados positivos para aplicação em VANTs, sendo seu desempenho satisfatório na estimação dos parâmetros em todos os cenários considerados. O erro obtido nas estimativas dos parâmetros chegou a diminuir até 1,5% em um dos parâmetros, na nova abordagem, o tempo de convergência do novo algoritmo chegou a reduzir na faixa de 100 segundos e a entropia dos sinais utilizados para a estimação paramétrica chegou a ter um aumento de 3,3646 quando comparado a metodologia original, garantindo que a informação para a estimação paramétrica não seja perdida quando o sinal de excitação é filtrado pelo controlador do sistema.
Fibrose hépatique chez le chien, proposition d’un nouveau test biologique non invasif d’évaluation de la fibrose hépatique chez le chien
Authors: Lecoindre Patrick , Chevallier Michèle , Lecoindre Alexis , Menard Maud
Published: April 2021

L'évaluation de la fibrose hépatique est incontournable dans l’évaluation et la gestion thérapeutique des hépatopathies chroniques canines. Les données épidémiologiques, la clinique, la biologie ou l’échographie ne permettent généralement pas de confirmer l’existence d’une hépatite chronique et d’une fibrose, sauf dans les cas d’affections très évoluées au stade de cirrhose. L’histologie hépatique est incontournable pour établir un diagnostic fiable et un pronostic, mais il existe des variations importantes d’interprétation des images histologiques et le caractère invasif de l’acte biopsique est souvent un frein pour le propriétaire et le praticien. Au cours des dernières années, des approches non invasives basées sur la mesure de plusieurs biomarqueurs sanguins ont été validées et sont largement utilisées en médecine humaine. Une étude récente chez le chien a eu pour objectif de construire un test biologique non invasif permettant de diagnostiquer et d’évaluer la fibrose hépatique chez le chien. Mots clés : hépatite chronique, fibrose, chien
Unité du vivant, biomimétisme : conférences d’Erik Orsenna et Gilles Bœuf lors de la séance solennelle de l’Académie vétérinaire de France
Authors: Fabre-Deloye Agnès , Angot Jean-Luc
Published: April 2021

Vivant, Biomimétisme, Bio-inspiration, Académie Vétérinaire de France
PERSEKUTUAN
Authors: Purba Mida
Published: April 2021

This article wants to explore the doctrin of Trinity by looking at the experience of the believers of the early church. Their encounter with God which they saw in Jesus himself and in Spirit provide the notion of the doktrin of Trinity. The very being of God who reveal Himself in Jesus dan in Spirit shows a harmonius relation among them and simultaniously shows a communion. This communion becomes model of the communion of the believers. The writer uses hermeneutic approach to analyze topic of discussion.
Diseño de un controlador para sistemas de refrigeración aplicando índice de confort térmico simplificado
Authors: Alejo-Chan Francisco Javier , Díaz-Méndez Sósimo Emmanuel , Alazki Hussain
Published: April 2021

This work, the objective is to study a simplified thermal comfort index and apply it to a model of a building with a cooling system in order to check if this simplified comfort index works as a substitute for the standardized index that is indicated in international standards and lead to the decrease in the use of six input variables to only two, which would present a reduction in the number of measuring instruments to be used in real applications. This application presents a Derivative Integral Proportional Controller (PID) to calculate the temperature that satisfies the conditions so that inside the building a comfortable environment is maintained following the scales of the comfort indices. Comparisons of temperatures, thermal comfort scales and percentage of dissatisfied people in both models are required to obtain a validation. The programming of the building’s mathematical models as of the simplified and standard thermal comfort indices is planned to demonstrate based on block diagrams using the software Matlab® on its Simulink platform.
A educação inclusiva na formação inicial do professor: um novo cenário no ensino superior
Authors: da Silva Francyne Monick Freitas
Published: April 2021

As instituições de ensino superior têm desafiado a formarprofessores que atenda a Política Nacional de EducaçãoEspecial na Perspectiva da Educação Inclusiva. Este trabalho teve como objetivo estudar a presença da Educação Inclusiva na formação inicial do professor da educação infantil e anos iniciais em uma IES pública federal. A metodologia envolveu questionários, pesquisa documental e análise descritiva dos Trabalhos de Conclusão de Curso (TCC’s) e do Projeto Pedagógico de Curso (PPC). Os resultados apontaram discretointeresse sobre o tema “educação inclusiva”. O PCC do curso estudado oferta um número significativo de disciplinas que elucidam sobre a Educação Inclusiva, porém não é um eixo que emerge nas discussões teórico-metodológico e nem nas práticas pedagógicas na formação inicial
Learning Implementation for Students with Special Needs in Inclusive Schools During the Covid-19 Pandemic
Authors: Prasetyo Teguh , Supena Asep
Published: April 2021

Learning activities during the Covid-19 pandemic are a new challenge for teachers in schools. especially special companion teachers or GPK in inclusive primary schools. GPKs still have to provide maximum service related to the learning process carried out during the Covid-19 pandemic. The purpose of this study was to obtain information related to the implementation of learning for students with special needs (PDBK) in inclusive schools during the Covid-19 pandemic. The research was conducted using a qualitative approach to the type of case study. The subjects studied were three GPKs in the Kreativa Inclusive Elementary School, Bogor City. Data collection was obtained through questionnaires and semi-structured interviews conducted online. Data analysis was carried out in a descriptive qualitative manner with the help of nvivo 12 plus. The results showed that the PDBK learning during the Covid-19 pandemic was as follows; (1) the GPK has prepared learning tools, especially individual learning programs, (2) offline learning in classrooms and center rooms focus on developing PDBK life skills, (3) learn the content is the same as before the pandemic, (4) online learning is carried out through the zoom application and WhatsApp, and (5) the process of assessing learning outcomes using google forms and worksheets related to PDBK learning activities. The learning challenges during the Covid-19 pandemic faced by GPK, namely; decreased learning outcomes of PDBK, problems with GDPK tantrums during online learning, and communication problems to provide an understanding of learning.
Penerapan Face Recognition pada Aplikasi Akademik Online
Authors: Utomo Budi Tri , Fitri Iskandar , Mardiani Eri
Published: April 2021

In the era of big data, the biometric identification process is growing very fast and is increasingly being implemented in many applications. Face recognition technology utilizes artificial intelligence (AI) to recognize faces that are already stored in the database. In this research, it is proposed to design an online academic login system at the National University using real time face recognition used OpenCV with the Local Binary Pattern Histogram algorithm and the Haar Cassade Classification method. The system will detect, recognize and compare faces with the stored face database. The image used is 480 x 680 pixels with a .jpg extension in the form of an RGB image which will be converted into a Grayscale image., to make it easier to calculate the histogram value of each face that will be recognized. With a modeling system like this it is hope to make it easy for user to log into online academics.Keywords:Face Recognition, Haar Cascade Clasifier, Local Binary Pattern Histogram, Online Akademic, OpenCV.
Rancang Bangun Media Pembelajaran Tenses English Berbasis Android menggunakan Algoritma Fisher-Yates
Authors: Vebiant Kiki , Wahyuddin M Iwan , Komala Sari Ratih Titi
Published: April 2021

English is a language that is widely used in various countries in the world. This makes english an international language and also must be studied in schools or even universities. In english, the verb used will be different at different times, places, and also events or it can be called a change in the verb (tense). So, learning and mastering tenses in english is the basis for learning or mastering english. This study aims to design and build an Android-based learning media for english tenses. The design applies a form of english tense quiz using the Fisher-Yates algorithm, which is a randomization algorithm that can randomize the order of the quiz questions so that the order of the quiz questions is not always the same and there are no repeated quizzes. The expected results will later become a learning medium for people who want to learn or master english and can understand the tenses in english.Keywords:Android, Fisher-Yates, Tenses, Learning Application.
EFFECTIVENESS OF EPIDURAL STEROID INJECTION FOR THE MANAGEMENT OF CHRONIC LOW BACK PAIN.
Authors: Ranjan Singh Ravi , Singh Bharat
Published: April 2021

INTRODUCTION: Low-back pain is a common clinical presentation of herniated lumbar disc. The incidence of low back pain is high in our country due to difcult working and living environment. The initial treatment of low back pain is conservative. Epidural steroid injection (ESI) is being slowly established as a simple, effective and minimally invasive treatment modality. The aim of this study is to assess the effectiveness of epidural steroid injection for low back and radicular pain. MATERIALS AND METHODS :This is a Prospective observational study. It was carried out on the patients presenting with low back pain due to herniated lumbar disc not responding to conservational management and had Magnetic Resonance Imaging (MRI) proven lumbar disc prolapsed at different level. Injection Methyl prednisolone 80 mg and 2 ml of 0.5% bupivacaine was diluted in 8 ml of normal saline and injected into the affected lumbar epidural space. The functional status of the patient and the severity of pain were evaluated before injection and after injection during the follow-up period by using Ostrewy disability index and visual analogue score. RESULTS: Fifty six patients received the epidural steroid injections, among them three patients did not came for regular follow up till six months and six patients required surgery . remaining forty seven were analyzed , among them 27(55.44%) were male and 20(42.55%) were female. The functional status and pain response of the patients were improved signicantly during all the follow-up periods (p < 0.001). The success rate of this study was 83.92%. No major complications were encountered. CONCLUSION:The ESI is a simple, safe, effective and minimally invasive modality for the management of lumbar radicular pain.
A CASE SERIES OF NEUROENDOCRINE NEOPLASMS OF GASTROINTESTINAL TRACT: A REAPPRAISAL OF NEWER CONCEPT OF THE UPDATED WHO CLASSIFICATION OF NEUROENDOCRINE LESIONS CITING A RARE & FASCINATING CASE OF COEXISTING INTESTINAL TUBERCULOSIS.
Authors: Kanti Das Tushar , Mukherjee Sanghamitra , Mahata Manisha , Hota Sarbashis
Published: April 2021

Neuroendocrine neoplasms are an important subcategory of tumours encountered in gastrointestinal tract and lung. Previously known as
'Carcinoid tumours', Considerable confusions prevailed regarding the nomenclature, diagnostic categories as well as prognostic classication of
this group of tumours; until recently, in 2018, a uniform framework of classication was attempted by WHO. Here, we discuss nine cases of
neuroendocrine neoplasms of GI tract diagnosed in our Institution over past two years, focussing on the application of this classication system, the
key concepts behind it and also the points to be addressed in critical scenarios while making a diagnosis. A fascinating case of coexistent
neuroendocrine carcinoma and intestinal tuberculosis is specially highlighted in this article, as probably, it is the rst case reported of its genre till
now, as far our knowledge goes.