bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisa keberadaan lembaga kesejahteraan sosial anak (LKSA) di Kabupaten Sidoarjo
Authors: Sutinah Sutinah
Published: October 2021

Di Indonesia, diperkirakan jumlah anak terlantar sekitar 3,5 juta jiwa. Ini pun terbatas pada kelompok anak-anak yang yatim piatu dimana dari jumlah itu hanya sedikit di antara mereka yang terjangkau pelayanan sosial. Di Kabupaten Sidoarjo sendiri, jumlah anak terlantar, anak yatim dan anak yatim piatu yang tinggal di berbagai panti diperkirakan mencapai angka ribuan, bahkan lebih, dan tidak mustahil pula angkanya kini terus bertambah karena tekanan kemiskinan dan kondisi perekonomian yang tak kunjung stabil. Kegiatan sebagaimana dilaporkan, selain mencoba melakukan indentifikasi keberadaan LKSA di Kabupaten Sidoarjo dalam mengimplementasikan SNPA, juga sekaligus akan mengkaji dan merumuskan sebuah pendekatan dan model penanganan anak-anak yang terlantar yang ada di panti. Hasil akhir dari kegiatan ini diharapkan akan diperoleh informasi yang dapat digunakan sebagai bahan penyusunan kebijakan dalam mengoptimalkan peran LKSA dalam pemenuhan hak serta perkembangan anak asuhnya. Dengan demikian penelitian Analisa Keberadaan Lembaga Kesejahteraan Anak (LKSA) Di Kabupaten Sidoarjo menjadi penting untuk dilaksanakan. Metode yang digunkan pertama yaitu mengkaji dan menganilisis data sekunder. Kedua melakukan review. Dan ketiga yaitu melakukan penggalian data primer ke lapangan. Hasil studi ini menunjukkan kondisi LKSA di Kabupaten Sidoarjo masih banyak yang belum memenuhi standarisasi yang telah ditetapkan dalam SNPA. Kendala yang dihadapi pengurus LKSA dalam memenuhi standarisasi SNPA, selain berkaitan dengan keterbatasan dana dan SDM, juga karena jumlah anak asuh yang dilayani tidak sebanding dengan kemampuan pendanaan dan SDM yang diimiliki. Kedua, bagi anak-anak asuh panti, situasi problematik yang mereka hadapi terkait dengan kondisi LKSA.
Kehidupan keluarga “long distance marital in relationship”
Authors: Primasari Devi Anjas
Published: October 2021

Keluarga kontemporer dipahami sebagai hubungan di mana individu tinggal bersama dengan komitmen, membentuk unit ekonomi dan mengasuh anak, memiliki identitas yang melekat pada kelompok. Dalam proses kehidupan, masyarakat mengalami perubahan seiring dengan tuntutan kebutuhan dan kebijakan pembangunan atau kebijakan dalam industrialisasi telah memaksa seseorang untuk bermigrasi sementara, hal ini dikarenakan individu tersebut memiliki pekerjaan di sektor industri. Penelitian ini difokuskan pada strategi pasangan suami istri dalam mempertahankan keutuhan keluarga pada pernikahan yang long distance. Penelitian ini menggunakan paradigma interpretatif, dengan lokasi penelitian di Kota Surabaya. Penelitian ini dilakukan terdapat 5 informan dengan menggunakan tiga teori sebagai pisau analisis yaitu teori Perubahan Keluarga oleh William F. Ogburn, teori adaptasi oleh Robert K. Merton, dan teori Komunikasi Interpersonal Joseph A. Devito. Hasil penelitian menunjukkan bahwa kehidupan keluarga long distance marital in relationships dihadapkan kepada permasalahan-permasalahan seperti kepercayaan, kejujuran, keuangan, masalah anak, masalah dengan mertua, dan pemenuhan biologis. Setiap keluarga satu dengan yang lain memiliki strategi yang sangat bervariasi. Dengan perbedaan strategi dari masing-masing keluarga memiliki efek tersendiri terhadap keberhasilan pasangan suami istri dalam mempertahankan keutuhan rumah tangga selama terpisah oleh jarak.
Reduksi Informasi Hoax di Era Digital Melalui Pendidikan Karakter Berbasis Pancasila
Authors: Armawi Armaidy
Published: October 2021

Informasi sudah menjadi suatu kebutuhan utama bagi warga negara, namun fenomenanya ialah tidak semua informasi yang beredar di masyarakat ialah fakta, bisa jadi baru opini, atau bahkan suatu informasi yang tidak benar. Perkembangan teknologi informasi dan komunikasi secara langsung maupun tidak langsung memberikan dampak positif dan negatif di masyarakat. Adapun tujuan dari penelitian ini yaitu untuk mengetahui proses pendidikan karakter berbasis Pancasila di era digital. Penelitian ini menggunakan metode penelitian lapangan dan termasuk jenis penelitian deskriptif. Hasil penelitian menunjukkan bahwa pendidikan karakter berbasis Pancasila di era digital di HMP Demokratia PPKn FKIP UNS, Surakarta dilakukan dengan kegiatan peningkatan literasi mahasiswa melalui berbagai kegiatan seperti seminar, FGD, dan kelas kebangsaan. Adapun proses mereduksi informasi hoax dilakukan dengan cara cross check information, dan pendidikan karakter yang dilakukan melalui diskusi publik dengan dewan dosen. Literasi warga negara dalam hal berkewarganegaraan umumnya di dunia nyata, khususnya di dunia maya, sangat perlu diperhatikan. Salah satu cara membangun literasi kewarganegaraan tersebut melakukan reaktualisasi nilai-nilai Pancasila baik dalam kehidupan nyata maupun kehidupan maya yang pada saat ini sudah menjadi bagian dari kehidupan warganegara. Kemampuan literasi teknologi informasi dan komunikasi merupakan hal yang sangat penting dan diperlukan masyarakat dalam rangka menghadapi kemajuan era digital saat ini. Dengan literasi saja tidak cukup, untuk itu negara perlu memperkuat dengan nilai-nilai yang sudah dibangun sejak lama yaitu nilai-nilai Pancasila. Negara perlu memastikan bahwa nilai-nilai tersebut dipraktikkan untuk mencegah hal-hal yang dapat merugikan masyarakat pada umumnya.

Kata kunci:  Reduksi, Informasi Hoax, Pendidikan Karakter Pancasila.
Recurrent Osteomyelitis Requiring Surgical Management Secondary to Nail-Biting
Authors: Hoof Marcus , Cognetti Daniel J. , Mcclain William D. , Plucknette Benjamin
Published: October 2021

Case:

Onychophagia, or nail-biting, is a common habit seen in both children and adults. Harmful effects include oral exposure to a variety of pathogens and concomitant damage to dentition and fingers. This report focuses on the most severe reported case of recurrent osteomyelitis of the bilateral hands with destructive changes secondary to onychophagia.

Conclusion:

Successful treatment relies on a multidisciplinary approach which in this case included surgical management and counseling on cessation, with referrals to other providers to address underlying psychiatric and/or psychologic conditions that may predispose to this compulsion.
Buku Ajar KEWIRAUSAHAAN
Authors: Jamaaluddin Jamaaluddin
Published: October 2021

Dengan mengucapkan syukur alhamdulillah penulis telah menyelesaikan buku ajar KEWIRAUSAHAAN ini. Buku ini dibuaat dengan harapan memberikan kemudahan bagi siapa saja khususnya mahasiswa yang sedang kuliah untuk mendapatkan gambaran mengenai KEWIRAUSAHAAN. Yang semula masih belum sama sekali tersbersit keinginan untuk melakukan wirausaha menjadi muncul keinginan berwirausahanya. Bagi yang yang sudah muncul keinginan wirausahanya maka akan semakain greget keinginannya sampai menjadi pewirausaha. Sedangkan bagi yang sudah melakukan wirausaha akan semakin sukses dalam melaksanakan kegiatan wirausahanya. Buku ini akan menyampaikan beberapa teori yang berkaitan dengan kewirausahaan, dan juga memberikan pandangan dan penjelasan yang sangat gamblang mengenai wirausaha, dan disampaikan pengalaman pengalaman nyata penulis dalam menjalani hidupnya sampai penulis menekuni wirausaha dan menjadi sukses dan menjadi pemateri pada event – event besar kewirausahaan untuk membagikan ilmunya. Termasuk pada kampus Universitas Muhammadiyah Sidoarjo tercinta. Pada buku ini pembaca akan mendapatkan petunjuk praktis nya untuk menjadi pewirausaha handal, dimulai dari kenapa diperlukan pewirausaha ?, bagaimana seseorang dapat menggantungkan keinginan setinggi langit dengan menuliskan keinginan – keinginannya. Bagaimana memunculkan mental pewirausaha, tantangan – tantangan yang dijumpai pada saat awal melakukan wirausaha, membuat bisnis konsep dan bisnis plan, pengetahuan mengenai identifikasi karakter pembaca, Gambaran penentuan bisnis apa yang cocok untuk dilakukan, pelaksanaan operasional bisnis, pengetahuan tentang Hak Paten, franchise dan pajak akan dijelaskan semua secara gamblang pada buku ini. INGIN KAYA JADILAH PENGUSAHA, ini salah satu semboyan yang digembar gemborkan agar supaya pembaca semakin bersemangat untuk meraih kehidupan yang lebihm baik dan jauh lebih baik. Penulis tidak mengatakan jika menjadi karyawan tidak dapat menjadi kaya.
Inspirational Quotes: REFLEKSI MILENIAL, DIGITAL dan SPIRITUAL
Authors:   Eni Fariyatul Fahyuni, Istiqomah Istiqomah ,   Anshori
Published: October 2021

Alhamdulillahilladzi bi nimatihi tatimmush sholihat segala puji dan syukur seluas langit dan bumi kepada Allah Subhanahu Wata’ala atas seluruh nikmat dan rezeki yang dianugerahkan. Shalawat serta salam kepada Rasulullah Shallallahu ‘Alaihi Wasallam dari jiwa-jiwa yang berharap perjumpaan. Inspirational Quotes: Refleksi milenial, digital dan spiritual sejatinya adalah kumpulan quotes mahasiswa Magister Manajemen Pendidikan Islam Angkatan 2019 selama menempuh matakuliah digital sosiologi pendidikan islam dengan dosen pengampu Assoc. Prof. Choirul Mahfud ( familier dengan sapaan hangat Gus choi) di Universitas Muhammadiyah Sidoarjo. Terkadang kita takkan pernah tau nilai suatu momen sampai ia menjadi sebuah kenangan. Buku ini,merupakan buku pertama yang diadaptasi oleh kumpulan beberapa quotes para mahasiswa dari akun instagram @digitalsospen, yang ketika disematkan menjadi sebuah buku, tentunya ada sensasi yang berbeda. Beberapa quotes didalam buku ini bukanlah tulisan baru, tapi saat dibaca secara utuh seolah pertama kali membaca goresan-goresan inspirasi baru. Begitulah sejatinya alam semesta, terlalu sempurna untuk dibaca hingga dinikmati Indra kita dengan gegabah sebagai manusia.
Application of Neural Networks and Cokriging for Predicting Reservoir Porosity-Thickness (Σøh)
Authors: Yoshioka Katsuhei , Shimada Nobusuke , Ishii Yoshiro
Published: October 2021

The distribution of the porosity-thickness (Σøh) of the Arab C4 Zone in the offshore El Bunduq field was estimated using neural network and geostatistical techniques. The Arab C4 Zone is approximately 10 to 15 meters thick which corresponds to a time window of less than 20 milliseconds. The reservoir is faulted and the reflection has a poor signal-to-noise ratio. The study utilizes 21 seismic attributes which were derived from a 3-D seismic survey calibrated from 42 wells, 27 of which are deviated. The attributes include different types of amplitudes, complex trace statistics, sequence statistics and frequencies. Three methods are compared: (I) simple kriging using only well data, (II) the neural network technique using 3-D seismic and well data, and (III) cokriging using the output of the neural network technique. Cross validation tests indicate that Method III is not consistently more precise than Method I. Also Method II, in cross-validation tests, demonstrated relatively large dispersion between data and estimates. It appears that although neural networks achieve good correlation between seismic attributes and reservoir properties, the physical relationship remains ambiguous.
Comunicación no verbal durante la pandemia por la enfermedad de Coronavirus 2019
Authors: Borja-Villanueva César Andrés , Bernuy-Torres Luis Alexis , Gómez-Carrión Christian Esteban , Simbrón-Macera Adriana Paola
Published: October 2021

Objetivo: El presente estudio tiene como objetivo explorar las características de la comunicación no verbal durante la pandemia por enfermedad de coronavirus. Materiales y métodos: Estudio exploratorio y transversal, se trabajó en la población de Lima entre 18 y 65 años, con una muestra de 391 miembros, seleccionados con muestreo por conveniencia. Se aplicó un cuestionario virtual de 9 preguntas sobre la variable comunicación no verbal y 3 preguntas sobre datos de filiación. Resultados: Los resultados de la dimensión kinésica señalan que la mayoría no aumento o disminuyó su frecuencia de gestos y expresiones faciales (51,9%) y su amplitud de sonrisa (42,7%). En la dimensión proxémica, se encontró que la mayoría disminuyó considerablemente la frecuencia de sus besos en la mejilla (74,2%), de sus besos en los labios (56%) y de la intensidad de los besos (54,5%). Para la dimensión paralingüística, se encontró que la mayoría no aumento ni disminuyó el volumen de su voz (52,4%), la velocidad al hablar y la articulación de sus palabras (57,5%). Conclusiones: La pandemia por la enfermedad del coronavirus ha producido cambios en la comunicación no verbal. El más importante se da en los besos en los labios y la mejilla, que redujeron su frecuencia e intensidad; el volumen y la velocidad de la voz no ha sufrido grandes variaciones. Los gestos, las expresiones y la sonrisa tampoco ha sufrido cambios importantes.
Hyperlactatemia and its adverse patient outcomes among patients who underwent cardiopulmonary bypass surgery at national cardiac centre Addis Ababa, Ethiopia 2021. Retrospective observational study
Authors: Tesfaye Tigist , Mulu Getaneh Baye , Atinafu Bantalem Tilaye , Tarekegn Fetene Nigussie , kebede Worku Misganaw
Published: October 2021

Background: Hyperlactatemia and lactic acidosis are commonly encountered during and after cardiac surgery. Hyperlactatemia is highly suggestive of tissue ischemia and is associated with a prolonged intensive care unit stay, a prolonged requirement for respiratory and cardiovascular support, and increased postoperative mortality. Objective: To assess hyperlactatemia and adverse outcomes among patients who underwent cardiopulmonary bypass surgery at Cardiac Center Ethiopia, Addis Ababa, Ethiopia, 2021.Method: An institution-based retrospective cross-sectional study was employed among all patients who underwent cardiopulmonary bypass surgery from December to January 2020. Blood lactate samples were collected intraoperatively and postoperatively. We entered the collected data into Epidata version 4.2 and export it to SPSS 25 for analysis. We did descriptive statistics for categorical and continuous variables and chi-square to show an association between the outcome variable and independent variables. We entered variables fitted in bivariate analysis into multivariable analysis to show the strength of the association and the statistically significant variable.Result: The prevalence of hyperlactatemia in this study among patients who underwent cardiac surgery procedures at Cardiac Center Ethiopia was 37.5 %. A rise in lactate level prolongs ICU stay, prolongs intubation duration, and increases the need for Inotropes support. Lactate level was measured on the immediate postoperative day within 10 hours after the surgery and was defined as lactate level > 3 mmol/L in the first hour after surgery. Age > 40 years [AOR: 6.8 (95% CI 1.7-25), P=<0.008]. female gender [AOR: 1.8 (95% CI 1.1-3.8), P=0.048]. Variables statistically significant were declared at 95 % CI, p-value < 0.05.Conclusion and Recommended: An early rise in lactate levels in patients who underwent cardiopulmonary bypass surgery is a strong and robust predictor of morbidity. As a result, screening of patients in the preoperative period and strict follow-up management of those factors is recommended.
Is High Sensitive-Troponin I A Reliable Biomarker For Cardiac Injury In Methadone Toxicity? A Prospective Cross-Sectional Study
Authors: Shemirani Hasan , Sadeghi Masoumeh , Dehkordi Azadeh Davoudian , Gheshlaghi Farzad
Published: October 2021

Background: Methadone is a synthetic opioid mostly used for detoxification therapy, as its use increases; the possibility for methadone-induced cardiotoxicity may rise. The aim of this study was to determine the association of high-sensitivity troponin I levels as a predictor of cardiac injury in methadone toxicity.Methods: Sixty methadone toxicity patients included in this prospective cross-sectional study from October 2018-November 2020. High-sensitivity troponin I level and electrocardiogram were assessed in patients at admission. All patients underwent echocardiography at admission and 30 days later and compared this findings between two groups based on high-sensitivity troponin I results.Results: Mean age of the patients was 34.5±11.1 years (males: 66%). Twelve (20%) patients had positive high sensitive-troponin results. Long QT interval and inverted T in precordial leads were mostly observed in individuals with positive high-sensitivity troponin I (75% vs. 35%, P=0.013 and 83% vs. 16%, P<0.001, respectively). Patients with elevated troponin had reduced left ventricular ejection fraction in comparison to normal group during admission (43.1±15.4% vs. 55%, P<0.001) and this left ventricular ejection fraction remained abnormal after 30 days (43.7±21.6%). Patients in positive high-sensitivity troponin I group had higher regional wall motion abnormality frequency both at admission and 30 days later compared to the other group (0 day: 42% vs. 0, P<0.001, 30th days: 25% vs. 4%, P=0.020).Conclusion: Patients with simultaneous methadone toxicity and positive high-sensitivity troponin I had worse cardiac outcomes and this biomarker could be probably used for better implementation of therapeutic interventions and prognosis.
Stigma after being newly diagnosed with acute leukemia: the contributing factors among those patients
Authors: Lin Miaoran , Hu Rong , Jiang Xiao-Ying , Lin Ying-chun , Weng Yi-mei
Published: October 2021

Objective:

To date, little research has been done to answer whether people with acute leukemia (AL) experience stigma. No previous studies investigated stigma and its relationship with most common negative emotion and coping styles in patients newly diagnosed as AL. Therefore, the study was designed to find out stigma and its possible contributing factors among the patients with initial diagnosis of AL.
Methods:

A total of 167 patients newly diagnosed as AL were recruited and investigated by Social Impact Scale (SIS), Medical Coping Modes Questionnaire, Hospital Anxiety and Depression Scale. The data was analyzed by multivariate linear regression to identify influencing factors of stigma.
Results:

The mean score of SIS was 60.61 ± 9.45, with 13.17% of patients at high level. Almost individuals experienced anxiety or depression during first chemotherapy after diagnosis. The main coping strategy was acceptance-resignation. Patients with following characteristics tend to experienced stronger stigma: male, childless, lower family income, higher degree of dependence, having chronic diseases, more severe depression, and tendency to adopt acceptance-resignation.
Conclusions:

Patients newly diagnosed as AL were in moderate level of stigma. Effective measures were suggested to alleviate stigma the patients undergoing when struggling for complete remission, especially for those exposed to risk factors of stigma.
Current Pattern and Clinico-Bacteriological Profile of Healthcare Associated Infections (HAI) in an ICU Setting: An Observational Study
Authors: Daga Mradul Kumar , Mawari Govind , Wasi Saman , Kumar Naresh , Sharma Udbhav , Hussain Maryam
Published: October 2021

Objective

To understand the pattern and types of healthcare associated infections (HAI) at our healthcare facility, and to determine the common causative agents and their antibiotic susceptibility profile.
Methods

One hundred consecutive patients diagnosed with HAI were enrolled and monitored; the causative organisms isolated on culture were recorded and their sensitivity profile was generated.
Results

Of the 100 patients diagnosed with HAI (mean age ± SD being 42 ± 17 years), there were a total of 110 hospital acquired infections with 10 patients having two infections each. Out of 100 patients with HAI, 69 patients had ventilator associated pneumonia (VAP), 21 patients had catheter associated urinary tract infection (CAUTI) patients, and 20 patients had central line associated bloodstream infection (CLABSI). There were 10 patients with both VAP and CAUTI. All of the HAIs were device associated. A total of 76 pathogens were isolated on culture. No organism was isolated in 40 HAI. Majority (94.7%) of the organisms isolated from HAIs were gram-negative bacteria and all were multidrug resistant. Seventy-seven of the enrolled patients expired while 23 were discharged from the hospital
Conclusions

Our study demonstrated that HAIs occur in patients of all age groups; younger patients are not spared. Majority of the HAIs were caused by multidrug resistant gram-negative bacteria and were associated with high patient mortality. Acinetobacter species was the most common organism associated with HAI.
Changes in hyperglycaemia-related testing for prediabetes and type 2 diabetes mellitus management: a prospective, cross-sectional survey of 16 years of general practice data from Australia
Authors: Leigh Andrew , Hunter Jennifer , Harrison Christopher , Britt Helena , Molodysky Eugen
Published: October 2021

BackgroundThe rising prevalence of prediabetes increases the population risk of type 2 diabetes mellitus (T2DM), metabolic syndrome and cardiovascular disease. Early identification by General Practitioners (GPs) provides opportunities for lifestyle modifications that can lower these risks.MethodsThis study examined 16 years of annual trends (2000/01-20015/16) in hyperglycaemia-related testing for patients in Australia aged 13 years or older with, or at risk of a diagnosis of T2DM. The Bettering the Evaluation and Care of Health (BEACH) study is a national cross-sectional survey, with a single-stage, cluster sampling design. Approximately 1,000 GPs were randomly selected annually (2000/01-20015/16) from across Australia, who each recorded details of 100 consecutive clinical encounters with consenting patients. Means and 95% confidence intervals were adjusted for intracluster correlation and GP characteristics.Results15,679 GPs recorded details of 1,387,190 clinical encounters with patients aged 13+ years. Prediabetes and T2DM were managed at 0.25% (95% CI: 0.24-0.27%) and 3.68% (95% CI: 3.62-3.73%) of encounters respectively. By the end of the study, annual management rates were 2.3 times higher for prediabetes and 1.5 times for T2DM management. The likelihood of ordering at least one hyperglycaemia-related test during prediabetes management occasion was twice the likelihood in management of T2DM. For prediabetes, glucose tolerance tests were most common but from 2014/15, requests for HbA1c tests began to increase. For T2DM, HbA1c tests were most common, and requests for one or more glucose tests gradually declined.ConclusionThe observed 16-year annual trends align with the rising incidence of prediabetes and T2DM. GPs appeared to be strongly influenced by changes to the national insurance scheme and clinical guidelines for hyperglycaemia-related pathology testing. However, some GPs may have been pre-empting policy changes as there was also evidence of ‘unendorsed’ testing, notably for prediabetes that warrants further investigation. The increasing management rates for prediabetes, coupled with higher rates of pathology requesting have substantial resource implication. Calls to lower the risk threshold for prediabetes screening therefore warrant an economic analysis. Ongoing, reliable, up-to-date data is needed to inform clinical practice guidelines and policy in Australia.
Detection of an Autism EEG Signature Through a New Processing Method Based on a Topological Approach
Authors: GROSSI ENZO , White Rebecca , Swatzyna Ronald
Published: October 2021

A new pre-processing approach of EEG data to detect topological EEG features has been applied to a continuous segment of artifact-free EEG data lasting 10 minutes in ASCII format derived from 50 ASD children and 50 children with other Neuro-psychiatric disorders, matched for age and male/female ratios. Each EEG was manipulated using a Cin-Cin algorithm, based on an input vector characterized by a linear composition of city-block matrix distances among19 electrodes. From the resulting triangular matrix of 171 numbers expressing all of the one-by-one distances among the 19 electrodes a minimum spanning tree(MST) is calculated. Electrode identification serial codes, sorted according to the decreasing number of links in MST, and the number of links in MST are taken as input vectors for machine learning systems. With this method all the content of an EEG is transformed in 38 numbers which represent the input vectors for machine learning systems classifiers. Machine learning systems have been applied to build up a predictive model to distinguish between the two diagnostic classes. The best machine learning system (KNN algorithm) obtained a global accuracy of 93.2% (92.37 % sensitivity and 94.03 % specificity) in differentiating ASD subjects from NPD subjects. In conclusion the results obtained in this study suggest that the two new pre-processing methods introduced, in particular the MST algorithm, have great potential to allow a machine learning system to discriminate EEGs obtained from subjects with autism from EEGs obtained from subjects affected by other psychiatric disorders.
Orthorexia Nervosa: When Healthy Eating Becomes Unhealthy
Authors: Andreoli Audryn , Aragon Patrick J. , Bennett Demara B.
Published: October 2021

Purpose Orthorexia Nervosa (ON) is a recently proposed eating disorder that has gained growing acknowledgment. However, there exists a significant gap in the literature regarding ON. Additionally, the lack of formal criteria for the diagnosis of ON has led to a debate regarding whether it is a standalone diagnosis or part of another condition, including other eating disorders. This debate is further fueled by shared characteristics and consequences between ON and other disorders, namely Anorexia Nervosa (AN) and Bulimia Nervosa (BN). Moreover, ON has been recognized as highly prevalent in individuals’ post-treatment for AN and BN. Thus, this study aimed to determine whether eating disorder history predicts greater severity of ON symptomology. Additionally, we aimed to determine whether sex, racial, and age group differences exist in severity of ON symptomology.Method The Eating Habits Questionnaire (EHQ) was administered to 535 individuals along with questions regarding previous eating disorder history and demographic variables. Results Analysis confirmed that individuals previously diagnosed with an eating disorder and those who previously received eating disorder treatment demonstrated higher ON symptomology severity. Minimal-to-no group differences among sex, race, and age in EHQ scores, except for Caucasian/White individuals scoring higher than Asian/Asian American individuals, were revealed.Conclusion ON is highly prevalent among individuals previously diagnosed with an eating disorder and those who previously received eating disorder related treatment. Little to no age, sex, and racial differences were demonstrated in ON symptomology. Level III: Evidence obtained from well-designed cohort or case-control analytic studies
Identification of Aquaporin Gene Family in Response to Natural Cold Stress in Ligustrum × Vicaryi Rehd.
Authors: Dong Jiahui , Niu Shance , Zhou Juan , Qian Ji , Zhao Mengnan , Meng Yu , Di Bao
Published: October 2021

Background: Maintaining water balance in various adversities is a difficult and critical challenge for plants. Studies have shown that aquaporins located on cytomembrane play an important role in maintaining water homeostasis under various environmental stresses. Some studies have shown that aquaporins are involved in the tolerance mechanism of plant cells under cold stress, and the aquaporin gene family is closely related to the cold resistance of plants. Ligustrum × vicaryi Rehd. plays a significant role in urban landscaping with poor cold resistance at the seedling stage and early planting stage. Screening the target aquaporin genes of Ligustrum × vicaryi related to cold resistance during natural cold stress will provide a scientific theoretical basis for cold resistance breeding of Ligustrum × vicaryi.Results: In this study, the genome-wide identification of the aquaporin gene family was performed at four different overwintering periods in September, November, January and April, and finally 58 candidate Ligustrum × vicaryi aquaporin (LvAQP) genes were identified. The phylogenetic analysis revealed that four subfamilies of the LvAQP gene family: 32 PIPs, 11 TIPs, 11 NIPs, and 4 SIPs, among which there were more genes in the PIPs subfamily than that in other plants. The key LvAQP genes were found through analyzing aquaporin genes related to cold stress in other plants and LvAQP genes expression profiles. The up-regulated key LvAQP genes were Cluster-9981.114831, Cluster-9981.104986, and Cluster-9981.120365, and the down-regulated key LvAQP genes were Cluster-9981.112839, Cluster-9981.109034, Cluster-9981.89369, Cluster-9981.110451, Cluster-9981.107281, Cluster-9981.112777, Cluster-9981.112789, Cluster-9981.122691 and Cluster-9981.88037. These genes play a key role related to cold tolerance in the nature low temperature growth stage of Ligustrum × vicaryi. Conclusions: This study systematically identified the AQP gene family in Ligustrum × vicaryi and screened for 20 differential expression LvAQP genes related to cold stress, among which 11 genes belonged to PIPs subfamily. The results of this research will lay the foundation for further biological function verification of cold resistance-related aquaporin candidate genes in Ligustrum × vicaryi, especially PIPs subfamily, and provide theoretical basis and technical support for improving seedling quality and breeding.
COVID-19 Among Doctors in Indonesia: Risk of Moderate-Severe and Behavior Adaptation in Personal Protective Equipments Usage After Infection
Authors: Yunihastuti Evy , Syam Ari Fahrial , Herikurniawan Herikurniawan , Soemarko Dewi Sumaryani , Wiraguna Andrian
Published: October 2021

Doctors have a greater risk of acquiring COVID-19 due to occupational exposure. Personal protective equipment (PPE) is an essential factor in reducing COVID-19 transmission. We aimed to evaluate the risk of moderate-severe COVID-19 infection and behavior adaptation in PPE usage among doctors who survived COVID-19 in Indonesia. This was an online population-based cross-sectional survey among Indonesian doctors of COVID-19 survivors. Bivariate and multivariate analyses were performed to determine factors associated with moderate-severe COVID-19 infection. A total of 389 doctors who survived COVID-19 infection across in Indonesia was included in this study. Most participants were young doctors (20-39 years: 69.7%), general practitioners (50.4%), working in COVID-19 designated hospitals (62.5%), and worked more than 40 hours/week (57.8%). Factors associated with moderate-severe COVID-19 were IMA moderate occupational risk (aOR 4.14, 95% CI: 1.11-15.47), age 40-59 years (aOR 3.24, 95% CI: 1.99-5.29), working in COVID-19 designated hospital (aOR 1.89, 95% CI: 1.18-3.01), and higher BMI (aOR 1.88, 95% CI: 1.00-3.54). N95 respirator and other PPEs use improved after these doctors recovered from COVID-19 infection in isolation and non-isolation rooms. In conclusion, working COVID-19 designated hospital, moderate occupational risk, higher BMI, and age 40-59 were associated with moderate-severe COVID-19 among doctors in Indonesia.
Productivity Boost – Five-Wave Longitudinal Study on Social Media Invasion Before and During COVID-19
Authors: Oksa Reetta , Pirkkalainen Henri , Salo Markus , Savela Nina , Oksanen Atte
Published: October 2021

The balance between work and private life has become vague due to the use of social media and flexible working conditions. The study drew from technostress and wellbeing literature and examined the behavioral and psychological outcomes of professional social media invasion, the perception that work-related social media usage interferes with one’s private life. Nationally representative five-wave survey data of Finnish employees (n = 840) were analyzed with hybrid liner regression analysis. Results showed an increase of social media-enabled productivity during the COVID-19 pandemic in Spring 2020 – Spring 2021. Professional social media invasion was associated with both within-person and between person effects on social media-enabled productivity. Additionally, work engagement was associated with within-person and between person effects. Higher educated and individuals with open personality reported higher social media-enabled productivity. We challenge the dominant view that professional social media invasion is solely a negative factor. Instead, perceived social media-enabled productivity should be recognized in organizations.
Imaging of shallow structures around Küçükçekmece Lake in Istanbul land area with high resolution geophysical data.
Authors: Alp Hakan , Tezel Okan , Vardar Denizhan , Alp Yeliz İşcan
Published: October 2021

The authors have requested that this preprint be removed from Research Square.
Epithelial–mesenchymal Transition Phenotype and Peritumoral Immune Cell Infiltration in Advanced Biliary Tract Cancer
Authors: Oh Chung Ryul , Kim Hyung-Don , Ryu Yeon-Mi , Lee Seonmin , Kim Danbee , Lee Da Sol , Jeong Jae Ho , Chang Heung-Moon , Ryoo Baek-Yeol , Kim Kyu-pyo , Kim Miyeon , Kim Sang-Yeob , Yoo Changhoon
Published: October 2021

BackgroundWe evaluated the clinical implications of epithelial–mesenchymal transition (EMT) markers and peritumoral immune cell infiltration in patients with biliary tract cancer (BTC) treated with gemcitabine plus cisplatin (GemCis).MethodsForty-five patients with advanced BTC who received GemCis were included as the study population. We conducted multiplex immunohistochemistry and examined EMT markers and their correlations with immune cell infiltrate at the invasive tumor margin. Study population was subdivided into two groups: twenty-four patients with overall survival (OS) less than 10 months (short-term survivor group, SS) and 21 with OS of 20 months or longer (long-term survivor group, LS).ResultsThe density of tumor cells expressing epithelial marker E-cadherin (E-cadherin+ CK+) at the invasive tumor margin tended to be higher in the LS group than in the SS group (p = 0.065). The density of tumor cells expressing mesenchymal marker vimentin (vimentin+ CK+) was significantly higher in the SS group than in the LS group (p = 0.021). Accordingly, the density of E-cadherin- vimentin+ CK+ cells was also significantly higher in the SS group (p = 0.020). The density of OX40 expressing cells (OX40+) was significantly higher in the SS group than in the LS group (p = 0.006). The density of vimentin+ CK+ cells was positively correlated with FoxP3+ CD4+ regulatory T-cells (r = 0.29, p = 0.047) and OX40+ cells (r = 0.48, p < 0.001).ConclusionsEMT-related features were enriched in BTC patients with poor survival outcomes and were associated with the immunosuppressive tumor microenvironment.
Do Institutions Moderate the Energy-Growth Affiliation? Evidence from Sub Sahara Africa Countries
Authors: Appiah Michael , Bugri Benjamin Adelwini , Antwi Frank
Published: October 2021

This paper aims to look into the role of institutional quality in regulating energy and growth affiliation. The countries of Sub-Saharan Africa (SSA) are studied from 1990 to 2019. CSD and SH tests were used to verify cross-sectional dependency and slope homogeneity properties. CIPS and CADF were used to investigate stationarity features. The Westerlund bootstrap cointegration test was used to analyze the long-tenure equilibrium affiliation among the variables and confirm cointegration in the extended period. To examine the long-short term performance between the variables, the CS-ARDL approach is used. To analyze the flow of causation, the study used the DH causality process. The findings reveal that energy has a negative and significant impact on growth. In both terms, industrialization and population have a negative and positive impact on growth, respectively. The DH heterogenous causality study reveals the mixed effect, i.e. one-way causal associations between growth and institutional quality, two-way causal associations between energy and population, and no causation with industrialization. Furthermore, institutional quality as a moderating variable harms growth. To achieve long-period growth, states should expand investment in renewable energy sectors, create well-resourced institutions, and plan for renewable energy development, according to this empirical research.
Co-Transplantation of Marginal Mass Allogeneic Islets with 3D-Culture-Derived Adult Human Skin Cells Improves Glycemia in Diabetic Mice
Authors: Oliveira Talita C. , Forni Maria F. , Santos Ancély F. , Wailemann Rosangela A. M. , Terra Leticia F. , Andreone Luz , Gomes Vinicius M. , Silva Janaina Macedo , Rosa-Fernandes Livia , Sogayar Mari C. , Palmisano Giuseppe , Labriola Leticia , Perone Marcelo J.
Published: October 2021

Background. Pancreatic islets transplantation represents a promising therapeutic option for severe type 1 diabetes (T1D). Maintenance of long-term viability of transplanted islets still requires improvement. Stem cell use represents an option to repair and replace damaged islets or, alternatively, b cells in T1D. Mesenchymal stem cells (MSC) have been proposed as adjuvants for islet transplantation, facilitating grafting and improving their functionality. Aggregation of stem cells has gained interest in providing physiological interactions between cells and enhancing the in situ concentration of modulators of inflammation and immunity.Methods. We established a hanging-drop culture by the spontaneous aggregation of adult human skin fibroblast-like cells as spheroids. Adult skin spheroid-derived cells (SphCs) were characterized in vitro and in vivo. We assessed the potential benefit of SphCs as adjuvants to improve islet functionality by cotransplantation with a marginal mass of allogeneic islets in an experimental diabetic mouse model. We characterized the secretome of SphCs by mass spectrometry-based proteomics.Results. SphCs were characterized as multipotent progenitors by their surface expression of markers analyzed by flow cytometry and multilineage germ differentiation capacity. Coculture of SphCs with anti-CD3-stimulated mouse splenocytes diminished the proliferation of T-CD4+ lymphocytes and biased splenocyte cytokine secretion through an increase in the Th2/Th1 ratio. SphCs conditioned media attenuated apoptosis of islets induced by inflammatory cytokine challenge in vitro. Administration (i.t.) of SphCs showed the absence of tumorigenicity in immune-deficient mice.SphCs improved glycemic control when cotransplanted with a marginal mass of allogeneic islets in an experimental diabetic mouse model without pharmacological immunosuppression. SphCs’ protein secretome differed from its paired skin fibroblast-like counterpart in containing 70% of up- and downregulated proteins and biological processes that overall positively influence islets such as cytoprotection, cellular stress, metabolism, and survival.Conclusions. Hanging-drop cell culture methodology might contribute to the development of an efficient way to improve transplantation outcome by reducing undesirable consequences of pharmacological immunosuppression as well as the number of allogeneic islets required to achieve normoglycemia in T1D transplanted patients. Further studies might determine whether the identified proteins sustain immunomodulation and/or cytoprotective effects in transplanted allogeneic islets.
Reducing Movement Synchronization to Increase Interest Improves Interpersonal Liking
Authors: Ravreby Inbal , Shilat Yoel , Yeshurun Yaara
Published: October 2021

Synchronization has been identified as a key aspect of achieving mutual goals and enhancing social bonding. While synchronization could be maximized by increasing the predictability of an interaction, such predictability is in tension with individuals’ level of interest, which is tied to the interaction’s complexity and novelty. In this study, we tested the interplay between synchronization and interest. We asked 104 female dyads to play the Mirror Game, in which they were instructed to move their hands as coordinately as possible, and then report how much they liked each other. Utilizing information theory and video processing tools, we found that a combination of movement synchronization and complexity explained liking almost two times better than movement synchronization alone. Moreover, we found that people initiated novel and challenging interactions, even though they paid a price – being less synchronized. Examining the interactions’ dynamics, we found that people who liked each other moved in a more synchronized, complex, and novel manner during most of the interaction. This suggests that in addition to synchronization, maintaining interest may be critical for positive social bonding. Thus, we propose a new framework in which balancing synchronization and interest, rather than merely maximizing synchronization, optimizes the interaction quality.
Clinical implications of device-detected atrial fibrillation in cardiac resynchronization therapy
Authors: Yoon Minjae , Oh Jaewon , Chun Kyeong-Hyeon , Yu Hee Tae , Lee Chan Joo , Kim Tae-Hoon , Pak Hui-Nam , Lee Moon-Hyoung , Joung Boyoung , Kang Seok-Min
Published: October 2021

Atrial fibrillation (AF) is associated with decreased cardiac resynchronization therapy (CRT) benefits compared to sinus rhythm (SR). Effective biventricular (BiV) pacing is a determinant of CRT success, but AF can interfere with adequate BiV pacing and affect clinical outcomes. We investigated the effect of device-detected AF on clinical outcomes and optimal BiV pacing in patients with heart failure (HF) treated with CRT. We retrospectively analyzed 174 patients who underwent CRT implantation between 2012 and 2019 at a tertiary center. The average BiV pacing percentage was obtained from the last available interrogation, and the optimal BiV pacing percentage was defined as ≥98%. Device-detected AF was defined as an atrial high-rate episode ≥180 beats per minute lasting more than 6 minutes during the follow-up period. We stratified the patients with SR at pre-implantation into device-detected AF and no-AF groups. A total of 120 patients had SR at pre-implantation, and 54 had AF. Among the SR patients, 19 (15.8%) showed device-detected AF during a median follow-up of 25.1 months. The proportion of optimal BiV pacing was significantly lower in the device-detected AF group than in the no-AF group (42.1% vs. 75.2%, P = 0.009). The device-detected AF group had a higher incidence of HF hospitalization, cardiovascular death, and all-cause death than the no-AF group. The device-detected AF and previous AF groups showed no significant differences regarding the percentage of BiV pacing and clinical outcomes. For HF patients implanted with CRT, device-detected AF was associated with lower optimal BiV pacing and worse clinical outcomes than no-AF.
Synthesis, Characterization and Cytoxicity Evaluation of Syzygium Aromaticum L. Bud (Clove) Essential Oil Nanoemulsion
Authors: Abadi Atena Vafaei Malek , Karimi Ehsan , Oskoueian Ehsan , Mohammad Ghasem Rahimi Kalateh Shah , Shafaei Negin
Published: October 2021

Background: The present study performs to improve the medicinal properties of Syzygium Aromaticum L by processing S. Aromaticum L. Bud essential oil (SABE) to the Nano Emulsion drug delivery system (SABE-NE) and investigate its anti-tumor and apoptotic impacts on human HT-29 colon cancer cells and to evaluate the toxicity of SABE-NE. Applying the ultra-sonication method and characterization by DLS and FESEM analysis facilitates the nano-emulsification procedure. Then both human cancer (HT-29) and normal (HFF) cell lines were evaluated based on the SABE-NE apoptotic and cytotoxic impacts. In an in-vitro section, flow cytometry method, Cas3 gene profile, AO/PI cell staining, and MTT assays apply to analyze the apoptotic and cytotoxic activities, and in further analysis measuring liver lipid peroxidation and antioxidant genes expression (SOD, CAT, and GPx) investigate in mice organs alterations. Result: As a result, produced 131.2 nm SABE-NE induces apoptosis response and cellular death (Cas3 up-regulation and enhanced SubG1 peaks), and subsequently, the HT-29 cells' viability can reduce significantly, while HFF cells indicate confined cytotoxic impacts. Moreover, in-vivo test results on mice liver demonstrate the cytoprotective properties of SABE-NE (reduced lipid peroxidation and increased antioxidant enzymes gene expression and non-detectable cytotoxic impacts).Conclusion: We produced a novel nature nanoemulsion drug delivery system called SABE-NE, which is cell-specific apoptotic inducer and thus can be utilized as an efficient anti-cancer compound for human colon cancer treatment. However, to verify and approve its cell-specific anti-tumor activity, further supplementary studies are required.
Amplitude of Somatosensory Evoked Potentials (SEPs) in Short-Latency SEPs Condition is 80% of that in Giant SEPs
Authors: Demura Ai , Demura Yutaka , Sato Kazuaki , Kinoshita Masako
Published: October 2021

The recording conditions of somatosensory evoked potentials (giant SEPs) are different from those of short-latency SEPs (SSEPs). We investigated the waveform characteristics obtained for each condition. Forty-eight upper limbs of 24 adult normal subjects (12 males, age 35.5 ± 9.7 years (mean ± SD)) were investigated. The main differences in recording conditions were reference electrodes (giant SEPs: the earlobe electrode ipsilateral to the stimulated limb, SSEPs: Fz), stimulus rate (1 Hz, 5 Hz), and bandpass filter (1 Hz–1 kHz, 20 Hz–3 kHz). SEPs were elicited by unilateral percutaneous electrical stimulation of the median nerve at the wrist. The amplitudes of N20o–N20 and N20–P25 were significantly larger in the giant SEP condition than in the SSEP condition (p<0.001). The mean + 3SD of N20–P25 amplitude was 10.0 µV in the giant SEP condition and 7.8 µV in the SSEP condition. The N20–P25 amplitude was significantly correlated between the giant SEP and SSEP conditions (R=0.64, p<0.001). Thus, the amplitude of SEPs in the SSEPs condition is equivalent to 80% of that in the giant SEPs condition. The information is useful for detecting cortical hyperexcitability in various neurological disorders including myoclonic epilepsy.
Network Community as a Resource for Supporting the Activities of Mathematics Teachers in the Context of COVID-19
Authors:   Far Eastern Federal University, Olga P. Zhigalova , Elena M. Pavlush ,   Far Eastern Federal University
Published: October 2021

The process of professional development in the information society is associated with the constant updating of organizational forms of interaction and the provision of conditions for the continuous professional development of a modern teacher. The transition to remote interaction of subjects of the educational process in the conditions of COVID-19 has significantly complicated this process. High demands were placed on the level of IT competencies of the teacher, related to the provision of the educational process in the conditions of using distance technologies and e-learning. The teacher has faced with complex professional tasks. At this stage, network communities have become a key resource for supporting the teacher's professional activities. The review of scientific and pedagogical publications on the research topic determines the basis of the article. The paper attempts to clarify the concept of "network professional community to identify the key capabilities of the "network professional community to identify the levels of effective interaction and constructive work, as well as to determine the optimal conditions for professional development in the conditions of remote interaction of the subjects of the educational process. The generalization of the regional experience of the network community is aimed at the formation of strategic directions in the formation of a continuous system of professional development of mathematics teachers in the information society, to determine the effective conditions for the organization of professional interaction in the network structure. Based on the results of monitoring the work of the network community of mathematics teachers, the authors identified active forms of professional interaction and relevant topics for professional development. The paper defines the structural components of the model of continuing education in the context of the network community of mathematics teachers, as well as the key characteristics of the network professional community at the regional level.