bluuebunny/crossref_metadata_2025 huggingface dataset:
Problems of Introducing Information and Communication Technologies into the Educational Process during the COVID-19 Pandemic
Authors: Kotyk Tetiana , Shaposhnikova Iryna , Berezyuk Olena , Savchenko Olga , Helesh Anna
Published: August 2021

Informatization of postmodern society is a promising path to economic, social and educational development. The informatization of education is aimed at the formation and development of the intellectual potential of the nation, the improvement of the forms and content of the educational process, the introduction of computer teaching and testing methods, allows solving problems at the highest level, taking into account world requirements. One of the important directions in the development of informatization of education in the context of a pandemic is new computer technologies. Interactivity, intensification of the learning process, feedback - are the real advantages of these technologies, which necessitated their application in various fields of human activity, primarily in those related to education and professional training. Now, in a pandemic, the number of studies has noticeably increased, the subject of which was the use of information and communication technologies in the educational process. The article deals with the problem of psychological and didactic aspects of the introduction of information communication technologies in the process of teaching students of higher educational institutions. An analysis of the problems and prospects of using information communication technologies in higher educational institutions was carried out, as a guarantee of building an intensive process of assimilating knowledge, skills, and abilities of students of higher educational institutions.
Big-Five Personality Traits and Cognitive Skills in Higher Education in the Pandemic Context
Authors: Salceanu Claudia
Published: August 2021

The SARS-Cov-2 pandemic created a severe psychosocial and medical shock all over the world. For more than a year, humanity struggled with adjusting to different measures that governments imposed on the population worldwide. Educational systems all over the world were forced to comply with the new conditions of activity. In this context, different reactions emerged, and skills were used and developed. The coronavirus pandemic was and still is a stressful worldwide event that disrupted, among numerous other things, the everyday life of professional activities and the manner of their deployment. This study aims to investigate the relationship between variables like analytical reasoning, text comprehension, detail perception, conscientiousness, emotional stability and autonomy. A sample of 327 students from Ovidius University of Constanta, aged between 19 and 50 years, were assessed using Cognitrom Assessment System. Results show that: (1) there is a positive correlation between analytical reasoning, text comprehension and detail perception; (2) analytical reasoning positively correlates with conscientiousness and emotional stability; (3) text comprehension correlates with emotional stability; and (4) detail perception has no significant correlation with any of the studied personality traits. Results are interpreted and discussed in the end of the article, in relationship with the use of these intellectual skills and personality traits in the context of the Covid-19 pandemic, especially by certain population categories which had to use the online environment for their regular professional activities.
Rufin Morozowicz (1851 – 1931). Legenda polskiego teatru
Authors: Uljasz Adrian
Published: August 2021

Komik Rufin Morozowicz (1851–1931) to aktor i śpiewak – legenda polskiej operetki. Osiągnął dorobek również jako artysta dramatyczny, dyrektor teatru i reżyser. Zdarzało się, że występował z sukcesem w operach komicznych. Z początku grał w warszawskich teatrach ogródkowych i na tzw. prowincji. Pracował w objazdowych zespołach aktorskich. W okresie 1875–1878 był aktorem Teatru Miejskiego w Krakowie. W 1881 r. otrzymał angaż w Warszawskich Teatrach Rządowych. Od tego czasu na stałe związał się zawodowo z Warszawą. Wykonywał zawód aktora do 1927 r. Był najbardziej znanym aktorem z rodziny Morozowiczów. Jego legendarne role to Menalaus w operetce Jacques’a Offenbacha Piękna Helena i John Styx w operetce tego samego kompozytora Orfeusz w piekle.
Adam Honory Kirkor i gazeta „Nowoje Wriemia” – nieznana karta polsko-rosyjskiej historii intelektualnej
Authors: Banaszkiewicz Mikolaj , Kotov Aleksandr
Published: August 2021

Artykuł traktuje o największym przedsięwzięciu wydawniczym Adama Honorego Kirkora (1818/1819–1886) – ogólnorosyjskiej gazecie codziennej „Nowoje Wriemia”. Tytuł nieodmiennie kojarzony z nacjonalizmem rosyjskim był w swoich początkach (1868–1871) organem prasowym służącym porozumieniu polsko-rosyjskiemu po powstaniu styczniowym. Liczne prace o wydawcy-redaktorze dziennika niewiele uwagi poświęcają petersburskiemu okresowi jego biografii, a już całkowicie rezygnują z omówienia politycznego dzieła życia A.H. Kirkora. Artykuł jest pierwszą próbą uzupełnienia tej luki. Autorzy wpisują powstanie i funkcjonowanie gazety „Nowoje Wriemia” w kontekst debat o przemianach w Imperium Rosyjskim „epoki wielkich reform” (lata sześćdziesiąte i siedemdziesiąte XIX w.). Transformacja struktur społecznych i dojrzewająca myśl nacjonalistyczna to centralne zagadnienia publicystyki tamtego czasu; stosunek do tych zjawisk określał identyfikację ideową poszczególnych organów prasowych. „Nowoje Wriemia” wpisywało się w nurt tzw. partii arystokratycznej, broniącej zastanej hierarchii społecznej (z typową dla niej dominacją warstw uprzywilejowanych) i sprzeciwiającej się polityce rusyfikacji zachodnich peryferii imperium pod płaszczykiem haseł egalitarystycznych. W artykule przedstawiono programowe wystąpienia dziennika w zestawieniu z wystąpieniami gazety „Wiest’ ”, będącej tubą propagandową partii arystokratycznej. Przywołano argumenty, jakimi posługiwali się przeciwnicy A.H. Kirkora: zarówno konserwatyści, jak i liberałowie. Wreszcie dokonano weryfikacji prezentowanych na łamach gazety poglądów z opiniami A.H. Kirkora, formułowanymi (anonimowo i pod nazwiskiem) w popetersburskim okresie jego życia. Bazą źródłową artykułu są roczniki gazet „Wiest’”, „Nowoje Wriemia”, „Wiestnik Zapadnoj Rossii” i „Gołos”, a także niewykorzystywane dotąd materiały ze spuścizny A.H. Kirkora w Bibliotece Jagiellońskiej.
The origins of electrical engineering studies in the Ukraine and their shaping under the influence of the European scientific school (the end of the 19th and the beginning of the 20th centuries)
Authors: Chrzan Krystian , Tverytnykova Olena , Gutnyk Maryna
Published: August 2021

The deployment of electrical engineering research in the second half of the 19th and at the beginning of the 20th c. is shown. The great attention is focused on the economic circumstances of the development of theoretical electrical engineering. Emphasis is placed on the leading role of Lviv Polytechnic. The names of professors who were at the origins of electrical engineering education in Lviv, Kyiv, Kharkiv and Odesa are given. It is claimed that the European School of Electrical Engineering directly influenced the development of relevant research in Ukraine.
СЕМИОТИЧЕСКАЯ ИНВЕНТАРИЗАЦИЯ ГОРОДА И ПРОБЛЕМА ИНТЕНСИВНОГО ПРОСТРАНСТВЕННОГО РАЗВИТИЯ (в печати)
Authors: Колодий Наталия Андреевна , Баджио Рудольфо , Гончарова Наталья Александровна , Чайка Юлия Александровна , Иванова Вера Степановна
Published: August 2021

Влияние, которое оказывают современные горожане на пространственное развитие городов, заставляет и градопроектировщиков, и тех, кто реализует различные городские проекты, обращать внимание на те языки описания города, которые создают доминирующий образ уникального пространства и территории. Это воздействие может сделать пространственное развитие гармоничным и устойчивым, а может препятствовать реализации любого городского проекта. В статье, посвященной анализу языков описания города, обсуждается ряд проблем, связанных с пониманием того, при каких условиях языки описания города способствуют формированию идентичности города и его аутентичному пространственному развитию, а при каких создают неоднозначные противоречивые образы. Методы. Методологической основой являлся структурно-семиотический подход, поскольку он выстраивает систему анализа города как текста, и города, как текстопорождающего механизма, смыслосоздающей системы. В качестве концептуального ориентира также использовалась концепция городского воображаемого (А. Блум, К. Линч, М. Де Серто), позволившая рассматривать этот феномен как продукт восприятия городской реальности, оформленный в виде различных интерпретативных схем и текстов. Семиотическая инвентаризация, связанная с пространственной системой современного города, нужна для того, чтобы понять: как будет «производиться» новый символический порядок города, его новая символическая вселенная. Результаты исследования, представленные в статье, основаны на интерпретации ментальных карт, диджитал-феноменов, что позволило воссоздать контуры визуального образа сибирского города (как целостного образования) с определённой системой кодирования смыслов. Выводы. Междисциплинарные городские исследования, интенсификация которых связана часто с попытками трансформировать город, создают объёмные описания культурного ландшафта города, где структурообразующим будет образ, не противоречащий сложившейся системе городского семиозиса
O zmienności granic nauki
Authors: Jedynak Anna
Published: August 2021

The limits of science change primarily as a result of new discoveries. But there can be other reasons, of a conceptual and/or methodological nature. The essence and structure of science can be understood differently, which results in different definitions of its limits. The text discusses some areas in which the limits of science were defined differently. Firstly, on the grounds of logical empiricism, views distant from direct experience, as generalisations and theories, have been excluded from science, narrowing its limits. Secondly, the lack of an unshakable and strictly empirical basis has been found within the limits of science, while previously that basis was thought necessary. Thus, the limits of science were again found narrowed. Thirdly, previously neglected and rather unwanted evaluative elements have been repeatedly discovered at the base of science. It was claimed to sanction them within the limits of science. In that case the latter per se would not change their range, however their concept would have to broaden. Last but not least, for various and not necessarily intentional reasons, the limits of science has become vague.
Tworzenie siebie i wolność. Myśl etyczna Foucaulta
Authors: Łojek Stanisław
Published: August 2021

In the later phase of his work, Foucault was particularly interested in exploring the possibilities of creating our own subjectivity and presenting its ethical dimension. The notion of pastoral power as well as the distinction between morality focused on ethics and morality focused on a normative code played a significant role in this undertaking. The former turned out to be particularly important in the context of Foucault’s earlier findings, according to which, a subject is a social construct, a product of regimes of power/knowledge. This was because pastoral power, although like any other kind of power it forms us from outside, strongly implies an active participation of the subject in the creation of himself. This kind of activity dominated also in morality focused on ethics which, according to Foucault, was practised by the Greco-Roman elites (above all in the first centuries of our era). In my text, I analyse the above themes in an attempt to show that in Foucault’s works they constitute the emancipation project of “new” morality.
Pochwała człowieka ludzkiego w „Kronice” Kadłubka. U samych początków myśli polskiej, u końca czasu
Authors: Żarowski Mirosław
Published: August 2021

Starting with the words that finish, or interrupt Master Wincenty’s Polish Chronicle, I interpret its historiographic content as characteristic of 12th century humanism, expression of love, of wisdom. The infallible condition of ethical arete may be found to be formulated in the last words of the Chronicle concerning humanity (affabilitas, humanitas) which consists in tolerant indulgence of others’ vices and modesty about one’s virtues.
Lower California development company
Authors: Gómez Cavazos Enrique Esteban
Published: August 2021

Una concesión territorial a finales del siglo XIX a la Mexican Land and Colonization Company de capital Británico que años atrás fue comprada a la International Company of México de capital estadounidense, desarrolla un inicial proyecto económico y urbanístico tratando de construir una colonia de irrigación para el valle de San Quintín y un centro agrícola potente como capital de la compañía. El interés del régimen de Porfirio Díaz (1876-1910) en ocupar estratégicamente el territorio y poblar la lejana península tenía una intención clara, la de desarrollar a través del capitalismo extranjero diversas poblaciones y tratar de consolidar ciudades en la costa del Pacifico. La colonia inglesa de San Quintín es un ejemplo del proyecto territorial del Porfiriato en la península de Baja California y cuenta con un valioso patrimonio industrial  desapercibido que debe de ser reconocido. Por eso, el objetivo de este texto en buscar en la historia industrial para encontrar las piezas en el territorio que narren su origen y describan su identidad.
Experiências com ferramentas digitais no ensino de estruturas arquitetônicas
Authors: Silva Felipe Tavares da
Published: August 2021

Entre 2011 e 2019, o conjunto das disciplinas de Estruturas de um curso de graduação em Arquitetura foi conduzido com experiências metodológicas incorporando simulações computacionais, aqui sumarizadas. As disciplinas têm ementas com temas que vão da mecânica e simulação estrutural; concepção estrutural; projeto e detalhamento de estruturas em concreto armado, em aço e em madeira. Esta experiência apontou que, alunos capacitados no uso de simuladores estruturais projetaram com uma consciência clara e profissional sobre a concepção Estrutural junto à Arquitetura, ao passo que verificaram a aceitabilidade estrutural com precisão. No entanto, o uso destes recursos adicionais demanda uma maior integração entre as disciplinas de estruturas e as disciplinas que lidam com conteúdo em comum: matemática; geometria, lógica de programação e projeto arquitetônico.
A CASE REPORT: CHALLENGES IN THE MANAGEMENT OF TOXIC MULTI NODULAR THYROID IN PREGNANCY WHO HAD CRISIS THYROID
Authors: Alisaputri Kurnia , Wibisono Sony
Published: August 2021

Managing crisis thyroid in toxic multi nodular thyroid in pregnancy is challenging. This case objective is to highlight comprehensive treatment going to safe mother & baby’s life. A woman, 43 years old in 13th week of her third pregnancy, admitted in emergency room with palpitating and vomiting as her chief complaints. Her complaints had started since she stopped taking propylthiouracyl. She used to take it since diagnosed hyperthyroid. She was diagnosed crisis hyperthyroid in pregnancy. The first main goal was to stabilize the patient, curing the precipitate factors, and assist her to have a healthy baby. She was discharged from hospital day 7th. She was routinely checked FT4 for evaluation and switch on Thyrozol during 25-26th weeks and continued it until postpartum. Her baby was delivered vaginally with normal APGAR score and growing well. Based on her experience, she agreed to have IUD to prevent unplanned pregnancy.
Knowledge, Attitude, and Behaviours Towards Covid-19 Transmission Among Jakarta-Bogor-Depok-Tangerang-Bekasi Residents
Authors: Desmawati Desmawati , Bachtiar Farah Dina , Fatema Kanis , Parveen Shahanaz
Published: August 2021

Jakarta-Bogor-Depok-Tangerang-Bekasi (Jabodetabek) is the city with the most populous population in Indonesia. This study aims to explore the knowledge, attitude, and behaviour of Jabodetabek people as an epicentre covid-19 in Indonesia. This study was a descriptive quantitative online study with a survey design used a self-developed online questionnaire on 297 Jabodetabek residents in Indonesia. The chairman of the neighbourhood was encouraged to roll out the google form (link) to as many participants as possible, and then the link was forwarded to the next participants and so on. Data were analyzed using descriptive statistics. Among the participants, 72.1 % were female, overall range of correct answers for knowledge questionnaire was 53.2-97.3%, that for attitude was 21.55-93.3% and for behaviors was 66.3-98.7 %. In general, participants had a good knowledge about the disease, a positive attitude, and behavior towards protective measures. However, the results showed that only 22.55% participants state Indonesian government can win the battle against covid-19, the rest (78.45%) less optimistic attitudes, and this will impact less good practice toward covid-19 in the future, although currently still 66.3% of participants following Government Indonesian policy. Findings of this study revealed that knowledge among people of Jabodetabek about covid-19 is satisfactory. Yet almost half of participants are lacking belief in the plague. Better trust and behavior is required to tackle Covid-19 in Jabodetabek-Indonesia.
The Effect of Cold Compress on Pain Intensity in Fractured Patients at RSUP H. Adam Malik Medan
Authors: Lubis Citra Amelia , Tanjung Dudut Dudut , Asrizal Asrizal Asrizal
Published: August 2021

Fracture occurs due to the damage of the shape and function of the bone, and the fractured patients generally experience pain. One of the interventions to reduce pain intensity in fracture patients is cold compress. This study aims to identify the effectiveness of cold compress on pain intensity in fracture patients in H. Adam Malik Hospital Medan. This is a quantitative study with a quasi-experimental design approach with an equivalent control group pretest-posttest design. The number of samples is 70 respondents consisting of 35 people for each intervention and control group, respectively, which was collated by consecutive sampling. Data analysis used paired t-test and independent t-test. The results showed that there was a significant influence before and after cold compress intervention on pain intensity (p value 0.001 (p = <0.05)). There is a significant difference between the intervention with cold compresses and the hospital standard intervention on pain intensity in fracture patients (p value 0.001 (p = <0.05)). It can be concluded that cold compress has a significant effect on the pain intensity in fracture patients. Cold compress is one of the nursing interventions that can help to reduce the intensity of fracture pain.
The Leadership of the Prophet: The Role Model of Today's Leaders
Authors: Safitri Eka , Abdurrahman Muhammad Fatih , Qona'ah Putri Fajriatin , Aini Wahyu Nur
Published: August 2021

In fact, every human being is a leader, either for himself or for others. The nature of leadership is closely related to a leader. Leadership is a trait that can influence, move or encourage others to achieve a predetermined goal. The essence of leadership in Islam leads a servant to true servitude to Allah. In Islam, a leader must be an example for his group, such as the Prophet Muhammad saw. The personality of the Prophet Muhammad saw. as a leader is exemplary because of his toughness which is not affected by the circumstances of the surrounding community which are still ignorant. This study aims to analyze the leadership style of the Prophet Muhammad that can be applied today. The data collection technique used reading and note-taking techniques and the data were analyzed using a qualitative descriptive. From the results of this study, it can be explained that the leadership style of the Prophet Muhammad that can be applied today is a democratic attitude. This study concludes that the Prophet Muhammad is a role model for leaders, even today leaders should apply the leadership style of the Prophet Muhammad who is religiously democratic.
Behaviors of the Yukon River Sediment Plume in the Bering Sea: Relations to Glacier-Melt Discharge and Sediment Load
Authors: Chikita Kazuhisa Augistine , Wada Tomoyuki , Kudo Isao , Saitoh Sei-Ichi , Hirawake Toru , Toratani Mitsuhiro
Published: August 2021

Sediment plumes, released to the Bering Sea from the delta front of the Yukon River, Alaska, are initiated mainly by glacier-melt sediment runoffs in the glacierized regions of the Yukon River drainage basin. The surface sediment plumes are extended around the fan-shaped Yukon River delta, which is followed by the northwestward dispersion. During continuous measure-ments of the Yukon River discharge and sediment load, behaviors of the sediment plumes were explored by shipboard observations in the Bering Sea offshore from the Yukon delta. At the high river sediment load of ca. 3000 kg/s, the plume partially plunged into the sea bottom layer. The plunging probably originated in the nepheloid-layer formation from the flocculation of river-suspended sediment, of which more than 90 %wt. is silt and clay (grain size d < 0.063 mm). In order to numerically obtain the area of the surface sediment plumes, a satellite image analy-sis was performed by using three near-infrared bands in MODIS/Aqua or MODIS/Terra. The plume area was significantly correlated (R2=0.735, p<0.01) to the sediment load averaged for the two days with time lags of 20 days and 21 days to the date of a certain satellite image. Hence, the dispersion of plume-suspended sediment appears to be controlled by the sediment runoff events in the Yukon River rather than the northward “Alaskan Coastal Water”.
Houston Ship Channel Expansion Channel Improvement Project (ECIP) numerical modeling report : BABUS cell and Bird Island analysis
Authors: McAlpin Jennifer , Ross Cassandra
Published: August 2021

The Houston Ship Channel (HSC) is one of the busiest deep-draft navigation channels in the United States and must be able to accommodate increasing vessel sizes. The US Army Engineer District, Galveston (SWG), requested the Engineer Research and Development Center, Coastal and Hydraulics Laboratory, perform hydrodynamic and sediment modeling of proposed modifications in Galveston and Trinity Bays and along the HSC. The modeling results are necessary to provide data for hydrodynamic, salinity, and sediment transport analysis. SWG provided three project alternatives that include closing Rollover Pass, Bay Aquatic Beneficial Use System cells, Bird Islands, and HSC modifications. These alternatives and a Base (existing condition) will be simulated for present (2029) and future (2079) conditions. The results of these alternatives/conditions as compared to the Base are presented in this report. The model shows that the mean salinity varies by 2–3 ppt due to the HSC channel modifications and by approximately 5 ppt in the area of East Bay due to the closure of Rollover Pass. The tidal prism increases by 2.5% to 5% in the alternatives. The tidal amplitudes change by less than 0.01 m. The residual velocity vectors vary in and around areas where project modifications are made.
“A brain to pick, an ear to listen and a push in the right direction” (John C. Crosby)
Authors: Farrant Catherine Anne , Tybura Julia , Rafe Melanie , Ackon Nelly , Schmidt Marie-Christin , Chantaboury Amonlath
Published: August 2021

This paper provides the context and background to a ‘Student Peer Mentoring’ scheme that was co-created with students and piloted within the Business Faculty in University of Greenwich. We reflect on sharing this experience at the annual SHIFT1 conference on Teaching, Learning and Assessment and the lessons learned that will support the further development of this scheme. Key themes that arose were around the value of mentoring to support first year students and the benefit for mentors in terms of their own self confidence and development as evidenced by their contribution to SHIFT. Lessons learnt were the need to provide more guidance to mentees in preparation for mentoring and providing supervision support to mentors to allow them to reflect on issues that arise out of mentoring. Our complex approach to evaluation was challenged given the small numbers of numbers of mentors and mentees. We concluded that qualitative evidence gives enough support for the success of this scheme. It is planned to provide mentor training to all students on a voluntary basis leading to enhanced peer relationships and support.
Autobiographical accounts of students working on the Innocence Project London (IPL): students telling their story about how working on the IPL affected their lives
Authors: Hewitt Louise , Owusu-Kwarteng Louise
Published: August 2021

This reflection on a presentation at the Greenwich Learning and Teaching Conference (SHIFT) 2021 shows how powerful a sense of belonging can be, not only for students, but also for academics. By sharing their autobiographical reflections’ project, the student and staff presenters so powerfully connected with their audience that everyone was struck by the importance of collaborations that give students a voice. The occasion both produced some unanticipated outcomes and enabled everyone to relate personal experience to that of others.’
BMSCs improve TNBS-induced colitis in rats through inducing Tregs differentiation by expressing PD-L1
Authors: Gao Fei , Fan Heng , Shou Zhexing , Dong Yalan , Zuo Dongmei , Yu Ting , Liu Yujin , Zhu Feng , Chu Si , Wei Chunzhu , Leng Xueyuan , He Hongxia
Published: August 2021

Objective
Bone marrow-derived mesenchymal stem cells (BMSCs) are a kind of stem cells with high differentiation potential and immunomodulatory ability, which has a broad prospect in the treatment of inflammatory bowel disease. The aim of this study is to investigate whether BMSCs could improve TNBS-induced colitis in Sprague-Dawley (SD) rats through inducing Tregs differentiation by expressing PD-L1.
Methods
BMSCs were isolated and identified by flow cytometry before being transfected with PD-L1 siRNA recombinant lentiviral vector. Then SD rats were randomly divided into 4 groups. Colitis induced by TNBS (sigma Aldrich) except normal group. On the fourth day of modeling, the rats in BMSCs control group and PD-L1 siRNA BMSCs group were injected with corresponding BMSCs through tail vein for 1 week, the dose was 5 × 106 cells. The normal group and model group were given the same volume of PBS.
Results
PD-L1 siRNA BMSCs and BMSCs could reach colon tissue in TNBS-induced colitis. BMSCs control group significantly improved the clinical symptoms and histopathological severity of TNBS induced colitis, but PD-L1 siRNA BMSCs group did not. We found that the percentage of Tregs in spleen and mesenteric lymph nodes decreased, the expression of PD-L1, IL10, PTEN was down-regulated, and the expression of p-Akt and p-mTOR was up-regulated in colon tissue after PD-L1 siRNA intervention.
Conclusion
This study suggested that BMSCs can induce the differentiation of Treg through inhibiting Akt/mTOR pathway by expressing PD-L1, which can significantly improve the symptoms and pathological damage of ulcerative colitis rats and affect the immune function.
The Effect of Triple-lumen Flushing Training based on the Guideline in the Competence of Nurses
Authors: Abasi Fatemeh , Bazrafkan Leila , mosalanejad leili
Published: August 2021

BackgroundNurses' clinical education is critical in their empowerment process. Due to the extraordinary sensitivity of special wards, nurse training, especially for novices, appears to be more necessary and critical. The present study aimed at determining how triple-lumen flushing training based on the guideline affected the capacity of nurses in Namazi Hospital's pediatric intensive care unit.Methods The current study was a quasi-experimental pre-test-post-test study conducted in December 2020 until April 2021 on 60 nurses working in the pediatric intensive care units of Namazi Hospital in Shiraz. The samples were counted and divided into two groups of 25 people using the census method. At the beginning of the study, all participants took a pre-test, and then one of the groups was chosen randomly and trained for 10 one-hour sessions based on the revised guidelines of Shiraz University of Medical Sciences professors of Nursing and Cardiology. The training was both theoretical and practical in nature. A four-choice test, a performance checklist, and a valid and reliable attitude questionnaire were used to evaluate the effect of empowerment training in changing the behavior of both intervention and control groups after two weeks. Data were analyzed by SPSS software version 23 using descriptive and inferential statistical methods.Results Data analysis revealed a statistically significant difference in knowledge, skills, and attitudes between the intervention and control groups, with a statistically significant coefficient (p 0.000). There is a positive and significant correlation between nurses' clinical knowledge and their clinical skills (r = 0.290, p = 0.041). In other words, nurses' clinical skills have improved in parallel with their clinical knowledge. Furthermore, there is no significant correlation between nurses' attitudes and their level of clinical knowledge (r=0.066, p = 0.650). After the intervention, there is no significant correlation between nurses' attitudes and their level of clinical skills (r=0.030, p= 0.836).Conclusion The current study's findings revealed that the educational intervention of triple-lumen flushing based on the designed guideline has significantly contributed to the excellence and promotion of knowledge, and as a result, the ability of nurses. Developing and implementing guidelines can improve nurses' abilities in specialized areas, particularly in special care.
Acoustic Möbius insulators from projective symmetry
Authors: Qiu Chunyin , Li Tianzi , Du Juan , Zhang Qicheng , Li Yitong , Fan Xiying , Zhang Fan
Published: August 2021

Symmetry plays a critical role in classifying phases of matter. This is exemplified by how crystalline symmetries enrich the topological classification of materials and enable unconventional phenomena in topologically nontrivial ones. After an extensive study over the past decade, the list of topological crystalline insulators and semimetals seems to be exhaustive and concluded. However, in the presence of gauge symmetry, common but not limited to artificial crystals, the algebraic structure of crystalline symmetries needs to be projectively represented, giving rise to unprecedented topological physics. Here we demonstrate this novel idea by exploiting a projective translation symmetry and constructing a variety of Möbius-twisted topological phases. Experimentally, we realize two Möbius insulators in acoustic crystals for the first time: a two-dimensional one of first-order band topology and a three-dimensional one of higher-order band topology. We observe unambiguously the peculiar Möbius edge and hinge states via real-space visualization of their localiztions, momentum-space spectroscopy of their 4π periodicity, and phase-space winding of their projective translation eigenvalues. Not only does our work open a new avenue for artificial systems under the interplay between gauge and crystalline symmetries, but it also initializes a new framework for topological physics from projective symmetry.
MicroRNA Expression Deregulated by Aberrant Methylation in B-ALL Mouse Model
Authors: Wang Yidan , Wang Yihan , Hui Hetong , Fan Xinyuan , Wang Tianqi , Liu LiMei
Published: August 2021

The expression of microRNAs (miRNAs) in the serum of B-cell acute lymphoblastic leukemia (B-ALL) patients is abnormal. However, the mechanism is not clear. Recent studies have shown that the methylation state of circulating cell-free DNA (cfDNA) is different between tumor patients and normal people. Therefore, we speculate that abnormal expression of miRNA may be associated with methylation in cfDNA. The aim of this study was to establish a fluorescently labeled B-ALL transplantation animal model, so as to explore the relationship between the serum miRNA expression and the related gene of cfDNA methylation. The expression levels of miRNAs were detected with quantitative real-time PCR (qRT-PCR). The cfDNA methylation levels of related gene were tested by bisulfite sequencing polymerase chain reaction (BSP). The result showed that the expression levels of miR-196b, miR-203, miR-34a-5p, miR-335-3p, miR-34b-5p, miR-615, miR-375-3p and miR-193b-5p in the serum of the model mice were significantly lower than those of the control (P < 0.05). The methylation level of miR-196b promoter in cfDNA of model group was significantly lower than that of the control group (P < 0.05), and there was no significant difference in miR-203 promoter. The methylation levels of miR-196b and miR-203 coding region in cfDNA of model group were significantly higher than those of the control (P < 0.05). The results indicate that CpG island hypermethyation in the miRNA coding region of cfDNA is related to the low expression of miR-196b and miR-203.
Effect of Metal Contamination and Pesticides on the Cellulase-producing Microbes Present in the Gut of Perionyx Excavatus
Authors: Samanta Tanushree , Das Ankita
Published: August 2021

Cellulase-producing microorganisms were isolated and identified as Micrococcus luteus, Bacillus megaterium and Enterobacter cloacae among the bacteria and P. boydii, Streptomyces sp. and Candida sp. among the fungal isolates from the gut of Perionyx excavatus. They were then subjected to two different doses of metal Zinc ((Dose I- 60mg/Kg and Dose II- 120 mg/Kg.) and two doses of two commonly used pesticides (Pendimethalin and Pretilachlor). It has been observed that out of the six cellulase-producing microbes, the higher dose of the metal was proved to be detrimental for three of them. Bacillus megaterium, that was found to be producing a sufficient amount of the enzyme, was absent even when it has been exposed to the lower dose of the metal. Also, the fungal isolates showed a decrease in number when exposed to higher dose of the contaminants. But the cellulase- producing bacterial isolates like Micrococcus luteus and Enterobacter cloacae were not at all affected by the presence of either metal or the pesticides. The experiment throws light on the microbe-earthworm relationship and effect of toxins and metals on the commercially- important microbes present in the soil and earthworm’s gut. The isolates that were present even at the higher doses of the metal and pesticides would be very promising for the production of large amount of the enzyme cellulase.
Short-Term Response Might Influence The Treatment-Related Benefit of Adjuvant Chemotherapy After Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma Patients
Authors: Liu Ao , Wang Yalin , Zhao Zhongxing , Geng Xiaotao , Wang Xin , Zhu Liqiong , Nie Yu , Li Minghuan
Published: August 2021

Background

Whether adjuvant chemotherapy (AC) after concurrent chemoradiotherapy (CCRT) could provide benefit to esophageal squamous cell carcinoma (ESCC) patients is controversial. Therefore, we decided to investigate the potential benefit of AC after CCRT for ESCC and to identify biomarkers predictive of a clinical benefit.
Methods

We retrospectively analysed the clinical data of ESCC patients with clinical stage II–IVa who underwent CCRT. Then, we compared patients who received CCRT and AC (CCRT + AC group) with those who received CCRT alone (CCRT group). Propensity score analysis, subgroup analysis and an additional Cox regression model were conducted to analyse the predictive factors. The overall survival (OS) and progression-free survival (PFS) rates were taken as the endpoints.
Results

From January 2013 to December 2017, 244 patients were recruited (n = 113 for CCRT + AC; n = 113 for CCRT alone) for the analysis. After propensity score matching was performed (1:1 and 99 patients for each group) with consideration of the basic clinical characteristics, no significant differences were found in OS (HR = 1.024; 95% CI, 0.737–1.423; P = 0.886) or PFS (HR = 0.809; 95% CI, 0.582–1.126; P = 0.197) between the two groups. The good short-term response subgroup showed a better PFS and favoured CCRT + AC treatment (HR = 0.542; 95% CI, 0.3356–0.8764; P = 0.008), the independent predictive role of which was confirmed in additional multivariate Cox regression analysis.
Conclusions

Although AC did not significantly improve PFS and OS for all ESCC patients after CCRT, the short-term response to CCRT might help identify a subgroup that will benefit, which needs further prospective research to confirm.
Systematic Analyses of the Expression, Function, and Prognostic Value of CCNBs in Breast Caner
Authors: Liu Xinyu , Tang Yuqi , Wang Shuang , Liu Shutong , Li Chenglin , Shi Chunying , Li Ling
Published: August 2021

Background Cyclin B (CCNB) family plays key roles in the cell cycle, cell division and proliferation. Three members of CCNB family have been identified, including CCNB1, CCNB2 and CCNB3. Many studies have explored the roles of CCNBs in the tumorigenesis and pathogenesis of different types of cancer. However, the expression level, function, and prognostic value of CCNBs in breast caner (BC) are still unclear.Methods We explored the specific alterations of CCNBs in BC and predicted their prognostic value for BC patients. Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, cBioPortal, STRING, Database for Annotation,Visualization and Integrated Discovery (DAVID) databases were used for above analyses.Results We found that CCNB1 amd CCNB2 were significantly overexpressed in BC compared with normal samples, but not CCNB3. Survival analysis showed that upregulated CCNB1 and CCNB2 expression levels were associated with poor prognosis of BC patients, while high CCNB3 expression was related to good prognosis for BC patients. Furthermore, gene oncology (GO) enrichment analysis was performed to reveal the functions of CCNBs and the interacted genes related to CCNBs. In addition, hsa-miR-139-5p and has-miR-944 were identified to be potentially involved in the regulation of CCNB1.Conclusion Our study suggests that CCNB1, CCNB2 are potential targets of precise therapy for BC patients and that CCNB3 is a novel biomarker for the good prognosis of BC patients.
Development of A Controlled-Environment Assay To Induce Iron Deficiency Chlorosis In Soybean By Adjusting Calcium Carbonates, pH, And Nodulation
Authors: Merry Ryan , Espina Mary Jane , Lorenz Aaron , Stupar Robert
Published: August 2021

Background Soybean iron deficiency chlorosis (IDC) is an important nutrient stress frequently found in high pH and/or soils high in calcium carbonates. To advance the understanding of IDC resistance in soybean, a rapid (21-day) controlled-environment assay was developed to investigate the effects of nodulation, pH, and calcium carbonate levels on soybean iron deficiency traits. This system was tested on four genotypes known to exhibit differences in iron efficiency, including two standard IDC check cultivars and a pair of near-isogenic lines exhibiting variation at an IDC resistance quantitative trait locus. Visual score, chlorophyll content, plant height, root dry mass, and shoot dry mass were measured to quantify iron stress. ResultsCalcium carbonate levels and nodulation were found to have the greatest effects on IDC severity. Increasing carbonate levels worsened IDC symptoms, while nodulation reduced symptoms in all genotypes. Higher pH levels increased iron deficiency symptoms in check genotypes ‘Corsoy 79’ and ‘Dawson’, but did not induce iron deficiency symptoms in near-isogenic lines. A significant interaction was observed between genotype, nodulation, and calcium carbonate level, indicating that a specific treatment level could discern IDC symptoms between genotypes differing in resistance to IDC. ConclusionsIDC symptoms were successfully induced in the Check Genotypes Experiment as well as the NIL Experiment, indicating the success of using a liquid CaCO3 source and this assay for inducing IDC in controlled environments. However, our results suggest that treatment levels that best differentiate genotypes for their IDC resistance may need to be determined for each experiment because of the unique way in which different genotypes display symptoms and respond to iron deficiency conditions.
De Winter ECG Pattern Can Be A Temporary ECG Phenomenon Related To Severe Stenosis of The Left Circumflex Coronary Artery: A Case Report
Authors: Wang Jian , Ding Faming , Li Jingsen , Xu Huipu
Published: August 2021

The de Winter ECG pattern consisting of ST-segment depression and tall symmetrical T waves on ECG, known as an ST elevation equivalent, accounts for approximately 2% of patients with occlusion of the proximal left anterior descending coronary artery (LAD). These patterns are considered static and persistent and are, on average, recorded 1.5 hours after onset. Here, we describe a case of the de Winter ECG pattern as a temporary ECG phenomenon associated with left circumflex coronary artery (LCX) stenosis.
The Effect of the COVID-19 Pandemic on BMI in Children and Adolescents: A Retrospective Cohort Study
Authors: Nasir Arwa , High Robin , Nasir Laeth
Published: August 2021

Background:The COVID-19 pandemic created circumstances with the potential to increase rates of overweight and obesity. We aimed to assess whether there were significant increases in BMI among a sample of children and adolescents during the year 2020compared to the two years prior to the pandemic. Methods:For this retrospective cohort study, data was obtained from the electronic medical records of 8398 children 3-17 years of age who attended3 consecutive well visits between June 1 and October 31 in 2018, 2019 and 2020 in a single center in the Midwest. Generalized linear mixed models were used to calculate the differences in average BMI and obesityrates over the three years.Results:Between 2019 and 2020, the mean BMI for the whole sample increased 3.2 percentile points (from the 70·5th to the 73·7th percentile; p<0·001)compared to an increase of 0.8 percentile point between 2018 and 2019 (p=0·008). The proportion of children and adolescents with obesity rose from 13% in 2019 to 15·2% in 2020 (p<0·001) compared to no significant increasefrom 2018 to 2019. Significant disparities in BMI were observed between socioeconomic and ethnic groups.ConclusionsSignificant increases in BMI and obesity rates occurred in 2020 in this sample. We propose that the circumstances surrounding the COVID-19 pandemic contributed significantly to these increases.
The Draft Genome Sequence of The Endophytic Streptomyces Strain VITGV156
Authors: P Veilumuthu , T Nagarajan , S Sasikumar , R Siva , Christopher J Godwin
Published: August 2021

Streptomyces species is one among the dominant group of bacteria in the family Actinobacteria with a rich repertoire of secondary metabolites. Secondary metabolites with antimicrobial activity and plant growth promotor have been isolated from various Streptomyces sp. Here in this investigation, we present the draft genome of a new species, Streptomyces sp. VITGV156 isolated from healthy tomato plant (Lycopersicon esculentum) which has some rare antimicrobial secondary metabolites, like coelichelin, fluostatins, vicenistatin, nystatin, sipanmycin, and informatipeptin. The genome is 8.18 Mb in size with 6,259 protein coding genes. The average GC content of the genome is 72.61 %. Preliminary analysis with antiSMASH 6.0 revealed the presence of 29 biosynthetic gene clusters for the synthesis of potential secondary metabolites. These includes 4 NRPS (non – ribosomal peptide synthetase), 7 PKS (Polyketide Synthases), 2 RiPP (Ribosomally synthesized and post-translationally modified peptides) clusters. When we look into genes associated with secondary metabolites, 406 genes are present which includes 184 genes for cofactor and vitamins, 72 genes for terpenoids and polyketides, 70 genes for xenobiotics and 80 genes for other metabolites are present. Comparative genome analysis of VITGV156 with its closest neighbor Streptomyces luteus strain TRM45540 revealed ANI 91.22% and dDDH value 44.00%.
Acute Lymphoblastic Leukemia Complicating Graves’ Disease in a Sudanese Adolescent Girl: A Case Report and Exploration of the Underlying Mechanism Possibilities
Authors: Fadlalbari Ghassan Faisal , Hassan Samar Sabir , Abdallah Asmahan T , Abusamra Samar Omer , Abdalrhman Abeer Mohamed , Abdullah Mohamed Ahmed
Published: August 2021

Background: Graves’ Disease (GD) related bone marrow injury presents usually as agranulocytosis or less commonly as pancytopenia. However, acute lymphoblastic leukemia (ALL) has been reported recently in an adult patient with GD. The underlying pathogenesis is not fully understood. Nevertheless, the harmful effect of anti-thyroid drugs or autoimmune reaction to bone marrow cells is anticipated to be the causative factors. Case report: A 16.5-year-old Sudanese girl with GD was on carbimazole for the first fourteen months of her illness, with irregular follow up, then it was withdrawn because she developed hypothyroidism for which she was put on thyroxine. Meanwhile, she developed severe anemia without fever which necessitated blood transfusion. Eight months later, she presented with thyrotoxicosis relapse, febrile illness and pancytopenia which was proved to be ALL on bone marrow examination. Conclusion: ALL must be considered when encountering a GD patient with pancytopenia.
Predation on Planted and Wild Bay Scallops (Argopecten Irradians Irradians) by Busyconine Whelks: Studies of Behavior Incorporating Acoustic Telemetry
Authors: Sclafani Matthew , Bopp Justin , Havelin Jason , Humphrey Corey , Hughes Scott WT , Eddings Justin , Tettelbach Stephen T.
Published: August 2021

Quantifying predator-prey interactions and gaining insights into predator behavior are crucial for optimizing restoration strategies; yet, such knowledge is often lacking for marine invertebrates. We examined potential impacts of predation by channeled (Busycotypus canaliculatus) and knobbed whelks (Busycon carica) on natural and planted populations of bay scallops in the Peconic Bays, New York, through laboratory and field investigations. Mean rates of predation by small channeled whelks were low: 0.06 and 0.005 scallops d-1 for adult and juvenile scallops; respective lab predation rates of small knobbed whelks on juvenile scallops were 24x higher. Channeled whelks usually did not damage shells of scallop prey (86%), but knobbed whelks typically notched the ventral shell margin (73%). In field plots where scallop densities were manipulated via removals/plantings, whelks consumed ~2% of ~19,100 planted juveniles; crabs and presumably finfish consumed over 40% in all trials overall. Acoustic telemetry revealed that tagged channeled whelks moved shorter distances and spent more time in plots planted with scallops versus those without scallops. Unexpectedly, whelks spent more time in low vs. high density plots, but consumed far more scallops in the latter. In trials without scallops, whelk movement rates were 5x higher, presumably due to increased exploratory behavior. Overall, whelks were most active during crepuscular hours and during periods of increasing wind speeds. Our results, combined with population abundance data, suggest that whelks (especially B. carica) are drawn to high density scallop plantings and may be important causes of bay scallop mortality in the context of restoration efforts.