bluuebunny/crossref_metadata_2025 huggingface dataset:
Caulobacter Strains Code for Novel Restriction Endonucleases That Protect Them from Bacteriophage Infections
Authors: Sisto Ian , Ely Bert
Published: February 2025

Bacteriophages grown on Caulobacter vibrioides strain CB15 have reduced plating efficiency on other Caulobacter strains. To determine the cause of this reduced plating efficiency, we performed a series of experiments that demonstrated that the reduced plating efficiency is due to a novel set of restriction and modification (RM) enzymes that are present in most of the Caulobacter strains that we tested. We then demonstrated that one of these RM systems recognizes the nucleotide sequence 5′-ATNNAT-3′. A careful inspection of the genome nucleotide sequences of each of the strains revealed that the genes coding for these RM enzymes have not been annotated or identified, suggesting that the proteins may differ from the common types of bacterial restriction and modification enzymes. In addition, the host strain NA1000 contains a 26 kb mobile element that provides resistance to incoming phages.
Dynamics of a Panzootic: Genomic Insights, Host Range, and Epidemiology of the Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b in the United States
Authors: Jahid Mohammad Jawad , Nolting Jacqueline M.
Published: February 2025

In late 2021, Eurasian-lineage highly pathogenic avian influenza (HPAI) A(H5N1) viruses from HA clade 2.3.4.4b were first detected in the United States. These viruses have caused severe morbidity and mortality in poultry and have been detected in numerous wild and domestic animals, including cows and humans. Notably, infected cows transmitted the virus to cats, causing extreme pathogenicity and death. While human-to-human spread of the virus has not been recorded, efficient transmission of the bovine-origin virus has also led to extreme pathogenicity and death in ferret models. Recently, markers in PB2 (E627K) and HA (E186D, Q222H), indicating mammalian adaptation mutations, were detected in an H5N1-infected patient manifesting critical illness in Canada. These, combined with instances of interspecies spread of the virus, have raised global public health concerns. This could highlight the potential for the virus to successfully adapt to mammals, posing a serious risk of a global outbreak. A One Health approach is, thereby, necessary to monitor and control the outbreak. This review aims to analyze the epidemiology, transmission, and ecological impacts of HPAI A(H5N1) clade 2.3.4.4b in the U.S., identify knowledge gaps, and inform strategies for effective outbreak management and mitigation.
Immunization Against Chlamydia trachomatis Polymorphic Membrane Protein D Tetrapeptide Motifs Limits Early Female Reproductive Tract Infection in a Mouse Model
Authors: Collar Amanda L. , Jamus Andzoa N. , Flanagan Julian , Core Susan B. , Geisler William M. , Wheeler Cosette M. , Frietze Kathryn M.
Published: February 2025

Background/Objectives: Chlamydia trachomatis (Ct) is a common pathogen causing urogenital, anal, oral, and ocular infections. Although extensive vaccine efforts have been underway for decades, there is no licensed vaccine available to prevent human Ct infection. Polymorphic membrane protein D (PmpD) is a highly conserved protein present on the surface of Ct elementary bodies, suggesting an important role Ct biology. Repetitive tetrapeptide motifs GGA(I,L,V) and FxxN are conserved across Pmps and are important for adhesion in the related Chlamydia pneumoniae Pmp21. Methods: Using bioinformatics approaches, we identified amino acids 270 to 294 of PmpD that included two GGA(I,L,V) motifs and an FxxN motif as vaccine targets. Synthetic peptides corresponding to these regions were chemically conjugated separately via the carboxy (C)- or amino (N)-terminus (FxxN 1.1 and FxxN 1.2) to the surface of Qβ virus-like particles (VLPs) and were tested for immunogenicity and protective capacity in mice. Results: Female mice immunized three times with a mixture of Qβ-FxxN 1.1 and Qβ-FxxN 1.2 vaccines without exogenous adjuvant elicited geometric-mean endpoint dilution titers near 104. Further, mice showed decreased infection at early time points when challenged vaginally with luciferase-expressing Chlamydia muridarum over 9 days and a faster time to undetectable infection compared to controls. Immunization with individual vaccines (Qβ-FxxN 1.1 or Qβ-FxxN 1.2) did not show the same degree of reduction. Conclusions: Vaccination against PmpD tetrapeptide motifs is a novel and promising approach for limiting initial Chlamydia infection and warrants further investigation to characterize the mechanism of protection.
Digital Integrated Design and Assembly Planning Processes for Sports Vehicles Using the Example of a Skateboard
Authors: Schuchter Timo , Till Markus , Stetter Ralf , Rudolph Stephan
Published: February 2025

The current product and assembly processes of system development in the vehicle industry are characterised by a multitude of different model formats, a relatively low level of data integration, and an unsatisfactory management of information. This article presents an integrated design and assembly planning process which applies several model-to-model (M2M) transformations in order to ensure a seamless transition from product requirements to an assembly system layout and design. The digital process employs a framework based on graph-based design languages (GBDLs) and achieves an integration in a model-based systems engineering (MBSE) industrial context. The underlying hypothesis that this seamless transition is possible is tested on the basis of the product and assembly system development of a sports vehicle. In this article, a skateboard is used for detailing and explaining the different modelling perspectives throughout the engineering and assembly process of this product. Due to a conscious application of GBDLs in an MBSE framework, it is possible to achieve a continuous sequence of M2M transformations which guarantees a maximum level of information integrity. These two aspects are cornerstones for a future integrated design automation of a product and its assembly system. It is important to note that the presented approach is universal and can be used in the production of components for the automotive industry, entire vehicles, and their assembly.
Reconstructing the Historical Density, Size, and Age Structure of the Noble Pen Shell (Pinna nobilis) Population: Insights from Malo Jezero Lagoon, Mljet National Park (Adriatic Sea)
Authors: Čižmek Hrvoje , Čolić Barbara , Zubak Čižmek Ivana
Published: February 2025

The noble pen shell (Pinna nobilis) is a key bivalve species found in the Mediterranean that has suffered dramatic declines due to mass mortality events (MMEs) caused by pathogens like Haplosporidium pinnae. This study looks at the historical population structure of P. nobilis in Malo jezero, a coastal lagoon in Mljet National Park, Croatia, using data collected before the MME. During a field survey in 2018, data on the population density, size, and age of 3800 individuals, using a grid-based transect method, were collected. The population density ranged from 7.50 to 55.83 individuals per 100 m2, with an average of 25.42 individuals per 100 m2, over 11 520 m2, reflecting a high abundance compared to other populations. All individuals were mature, with no juveniles or signs of recent recruitment. The estimated ages ranged from 8.00 to 44.34 years, with 20 individuals exceeding the expected maximum size. The population was comprised of older individuals, making it vulnerable to sudden events, due to a lack of younger individuals. The isolation of Malo jezero may limit larval exchange with other populations, contributing to recruitment challenges. This study provides important information for understanding P. nobilis populations and supports the potential of Malo jezero for future conservation and reintroduction efforts.
Innovative Long-Term Exploration of the Impact of an Ecological Core Constructed Wetland System on Tailwater Treatment: A Statistical Analysis Incorporating Temperature Factors
Authors: Li Yanchen , Mou Chaozhou , Niu Qigui
Published: February 2025

The purpose of this article is to evaluate the tailwater treatment capacity of an emerging constructed wetland using statistical knowledge. For this purpose, the quality of the influent and effluent from the Fangshangou River constructed wetland was monitored and tested for a period of 3 years. The total area of the ecological wetland land plot is about 59 acres, and it has been officially put into use since 2021. Since its operation, the wetland has maintained good long-term stability in tail water treatment, pollutant removal, and other aspects. Statistically, we used empirical cumulative distribution functions (CDFs), removal rates, and Spearman correlation tests to strongly argue for the stable operational efficiency and high purification capacity of this constructed wetland. The high-efficiency ecological core wetland and the surface flow wetland are the main components of the constructed wetland. The average removal rates of the chemical oxygen demand (COD), ammonium (NH4+–N), total nitrogen (TN), and total phosphorus (TP) were 36.34%, 57.61%, 48.49%, and 71.47%, respectively. The analysis results indicate that temperature can affect the tailwater treatment capacity of constructed wetlands to a certain extent. The results of this study provide an important basis for studying the purification capacity of the constructed wetland.
Recent Advances in Heavy Metal Adsorption via Organically Modified Mesoporous Silica: A Review
Authors: Ezzeddine Zeinab , Batonneau-Gener Isabelle , Ghssein Ghassan , Pouilloux Yannick
Published: February 2025

Despite the significant advancements in wastewater treatment technologies, the field still lacks a comprehensive synthesis of recent developments in heavy metal removal using functionalized mesoporous silica materials. Adsorption has emerged as a preferred method due to its versatility, efficiency, and cost-effectiveness. Mesoporous silica stands out as a leading adsorbent due to its porous structure and surface modification potential, yet there remains a critical need to systematically analyze and evaluate recent innovations in this rapidly evolving field. This review addresses this knowledge gap by consolidating and critically analyzing the recent literature on functionalized mesoporous silica for heavy metal ion removal from wastewater. Through a detailed examination of the maximum adsorption efficiencies of organically modified mesoporous silica-based materials for various metal ions, with particular emphasis on recent trends in removing heavy metal ions, this work provides a crucial foundation for understanding current capabilities and limitations. Additionally, by identifying patterns in synthesis methods, surface functionalization strategies, and performance metrics across different studies, this review offers valuable insights into optimization opportunities and unexplored research directions. The systematic compilation and analysis of these data will serve as an essential resource for researchers working to advance the design and application of modified mesoporous silica for diverse water pollutant removal applications.
The More Economic Approach to Exclusionary Abuses Under Article 102 TFEU
Authors: Dimitrova Emilia
Published: February 2025

The present paper examines in a comparative legal aspect the more economic approach in the ‘rule of reason’ doctrine, formulated in connection with the implementation of the American antitrust legislation, and the approach defined in the Guidelines on the application of Article 102 TFEU to exclusionary abuses, adopted by the European Commission. The purpose of the comparative legal research is to establish whether the approach taken by the European Commission to exclusionary abuses follows the analytical model of the ‘rule of reason’ doctrine.
Exposer des moulages. La campagne de substitution des sculptures des jardins de Versailles
Authors: Sarzeaud Nicolas
Published: February 2025

In 2013, the statue of Milo of Croton regained the place attributed to him by Louis XIV, at the entrance to the Tapis Vert in the gardens of Versailles. It is not Puget’s marble : sheltered in the Louvre at the start of the 19th century, it is too precious to be subject to the elements. Instead, a cast of the masterpiece, in resin agglomerated with marble powder, is exposed in place of the original. Therefore, anyone who wants to see Puget’s Milo has the choice between the Louvre and Versailles, of seeing the original work or the work in its original location. This substitution was part of a larger campaign, which began in 2008. Far from a dispersion of aura, these casts respond to the mission assigned to them, to transmit the experience of the masterpiece : perched on their pedestals, with label, they are photographed by the public, most of whom are unaware that they are reproductions. What is the status of these objects ? We questioned members of the public as well as professionals on the exhibition and conservation of these casts.
Copier l’original : dupliquer, répliquer, substituer, contrefaire. Exploration juridique de la « réplique »
Authors: Bretel Ronan
Published: February 2025

Replica is not a legal notion, but it can be defined with regard to neighboring legal concepts. To carry out this reflection, which focuses specifically on the identical copy, one must ask how the replica is the multiplier. A replica only exists if there is a base model, an original. Replication as an act thus raises the question of what is copied. A work of art constitutes indeed most of the time a “work of the spirit” (‘’œuvre de l’esprit’’ protected by the French copyright) mak-ing different legal objects coexist in the eyes of the law. A pure-ly intellectual and abstract (incorporeal) creation is only made accessible to the senses by a tangible property. Even though the two properties are theoretically independent, they coexist. The “original” that is duplicated is therefore both the “original creation” (for copyright purposes) and the original of the work of art (in par-ticular for eligibility for the droit de suite). In the idea that the replica exists only in its capacity of substitu-tion but has meaning only in that it is not substituted and exists only in relation to a first work, the question is posed of the term to designate the reproduced goods, and especially, the goods of reproduction which are distinguished from it (although identical). The regulatory power posed intellectual distinctions by holding an “original” as a model, with a set of standardized descriptive vocabulary (Marcus decree of 3 March 1981) to define it ; as a result of which it is possible to distinguish all the results of the replication : copies, reproductions, counterfeits, non-authentics, etc. Considering that the art market is founded on authenticity and desirability at the same time, the law organizes an artificial rare-faction by “re-originalizing” certain replicas of the edited artworks. They are named “multiples originaux” in French (limited edition artworks). The qualification is then essentially fiscal. It poses very complex distinctions to be applied for bronzes (in particular in the event of overmolding or posthumous casting) and intermediate works (e.g. counterproof, matrices) on which the jurisprudence continues to be built.
«As nearly as possible». Valeur et autorité du double dans la redécouverte de l’Assyrie au XIXᵉ siècle
Authors: Le Pape Yannick
Published: February 2025

La localisation de l’ancienne Assyrie, au début des années 1840, suscita un engouement tel que les musées occidentaux eurent tôt fait d’exposer une partie des trouvailles provenant de terre otto-mane. Une partie seulement, car tout ne pouvait être transféré en Europe ou aux Etats-Unis et des pertes, par ailleurs, furent vite à déplorer. Aussi les vestiges assyriens, dans leur majorité, existèrent-ils en premier lieu dans l’imaginaire occidental sous forme exclusive de répliques. Les dessins réalisés sur les chantiers, tout d’abord, incarnèrent le patrimoine assyrien en Occident à la manière de « copies conformes  » , dont l’autorité fut d’autant plus grande que les originaux avaient parfois disparu et que ces images étaient reprises de publications en publications. Les moulages et les autres procédés de copie en volume assurèrent aussi une visibilité inattendue à ce patrimoine lointain ou évanoui, sans compter que les musées eux-mêmes, désireux d’offrir à leurs visi-teurs une vision exhaustive de l’ancienne Assyrie, intégrèrent à leur parcours les duplicatas d’autres collections. Ce fut également au moyen de moulages qu’Austen Henry Layard, le découvreur de Ninive, fit connaître au public du Crystal Palace les vestiges des palais assyriens, reproduits « le plus fidèlement possible  » (« as nearly as possible  » ), en 1854. Parfois accueillies avec réserve, parfois dotées d’une réelle légitimité, ces copies témoignent à leur façon de la notoriété qu’acquit rapidement l’art assyrien, et ce furent même de tels « doubles  » qui, volant la vedette aux originaux, servirent souvent de modèles aux architectes ou aux artistes. Cet article en forme de petite enquête part sur les traces de ces multiples succédanés qui par commodité, par nécessité ou par fatalité, ont permis aux vestiges assyriens de vivre et même de survivre à leur propre redécouverte.
La crise des collections de moulages classiques au XXᵉ siècle en France et en belgique
Authors: Attout Antoine
Published: February 2025

While plaster cast collections reached their apogee during the 19th century, these collections started to disappear over the course of the 20th century. By examining some cases of plaster cast collections in France and Belgium the present article proposes to shed light on the underlying reasons for the dis-appearance of these collections. The reasons for the decline in plaster cast collections seems to be manifold and complex, stemming from ideological and practical changes in the fields of archaeology, art history, museology, and art academies. This article highlights three major ideological factors : the emergence of Processual archeology, the emergence of the concept of “uniqueness” of the work of art, and the rejection of academism.
Broken heart. Les xerox books de Barbara T. Smith
Authors: Delfiner Judith
Published: February 2025

Cet article propose une plongée au cœur d’un corpus insolite, les livres de l’artiste californienne Barbara T. Smith réalisés au moyen de la photocopieuse, ses xerox books (1965-66). L’étude plus précise de l’un d’entre eux, Broken Heart, nous permet de relever les enjeux d’une telle pratique où la technologie, détournée de sa fonction bureautique, devient un outil exploratoire et introspectif. Véritable sismographe des états d’âme de l’artiste, le photocopieur apparaît alors investi d’une humanité, entité jumelle de l’artiste à laquelle elle s’affronte et s’accouple. Paysages anatomiques autant qu’oniriques, les images ainsi produites témoignent d’une esthétique singulière qui renvoie paradoxalement aux expérimentations de l’aube de la photographie. Témoins fragiles du passage de la mécanisation à l’ère numérique, elles sont le théâtre où se déploient des mouvements contradictoires oscillant entre le visuel et le tactile, la présence et l’absence, le privé et le public, le physique et le psychique, le réalisme et l’abstraction, le mécanique et l’artisanal, le sériel et l’unique.
Image(s) multiple(s) et identité(s) hybride(s) : Étude des Reliquaires et Saints Suaires d’ORLAN
Authors: Petit dit duhal Quentin
Published: February 2025

Lors de performances chirurgicales au début des années 1990, ORLAN réalise deux séries d’œuvres  : les Reliquaires , qui sont composés de chair, de peau ou de graisse disposée dans une boîte faite de métal soudé, et les Saints Suaires , des gazes médicales imprégnées de sang séché sur lesquels est imprimé un autoportrait. Alors que ce corpus aurait été tout de même compris par le public si ORLAN avait réalisé une œuvre unique, le principe de la série lui permet d’aborder un concept sous différents angles ainsi que de remettre en cause ironiquement l’unicité du suaire du Christ. Cet article propose alors d’entrecroiser les concepts de série et de multiple, en tant que reproduction d’une œuvre, pour saisir la manière dont la répétition de formes plastiques met en crise le principe de l’unicité du suaire et du reliquaire tout en rendant compte de la volonté d’ORLAN de redéfinir son identité hors des féminités normatives.
L’oeuvre d’art à l’époque de sa reproductibilité numérique
Authors: Cotentin Régis
Published: February 2025

NFTs create a buzz on the networks and gain media attention because of the exorbitant sales figures they generate, but what about the real status of works certified by a NFT ? Can the owner of such a piece claim exclusivity, while a virtual work both grows and dissolves in an infinite amount of commutable data ? Can a NFT make unique what is reproducible ? Can the authenticity of a digital work be defined by an encrypted signature ? What about our actual relationship to the work of art in the era of digital reproducibility ?
Les relations tragiques entre vivants et morts à l’aube du théâtre occidental
Authors: Jouanna Jacques
Published: February 2025

La première tragédie conservée du théâtre occidental a été l’objet d’une révolution philologique au cours du XXe siècle. Cette tragédie est bien une pièce d’Eschyle, mais ce n’est pas les Suppliantes , pièce mythique, comme on le croyait encore au début du XXe   siècle par suite de l’importance du chœur  ; c’est les Perses , tragédie connue surtout par son aspect politique, la victoire des Grecs contre les Perses lors de la seconde guerre médique, vue du côté des Perses au moment décisif où le chœur angoissé des fidèles du Roi restés à Suse et la Reine qui vient d’avoir un rêve prémonitoire vont apprendre la défaite de l’expédition de son fils Xerxès par la bouche d’un messager et se terminera par le retour lamentable de Xerxès entouré de quelques survivants. Il est procédé dans la présente étude à une relecture de toute la tragédie à partir des relations entre les vivants et les morts, en accordant une place essentielle aux rites qui règlent leurs relations entre eux et leurs relations avec les dieux. Bien loin d’être secondaires, les nécessités du rite constituent le moteur de l’action expliquant l’arrivée de la reine, son départ et son retour, et surtout contribuent au spectacle en permettant l’apparition de Darius mort au centre de la tragédie, puis à la fin de la pièce la déploration de Xerxès et du chœur en l’honneur des morts lors de l’expédition. Une telle étude n’est possible que par une analyse en réseau d’une foule d’indications dramaturgiques incluses dans son texte par l’auteur, qui renseignent soit sur ce qui se passe (indications dramaturgiques contemporaines), soit sur ce qui s’est passé (indications dramaturgiques régressives), soit sur ce qui va se passer (indications dramaturgiques progressives).
Le monument funéraire d’un notable narbonnais : la mémoire familiale et une carrière d’exception. À propos d’une inscription de Paguignan (Aigues-Vives, Hérault)
Authors: Christol Michel
Published: February 2025

Une inscription incomplète (AE , 1951, 62), peu connue et peu utilisée, apporte des renseignements importants sur les débuts du culte d’Auguste divinisé en Narbonnaise. Elle concerne un notable de la colonie de Narbonne, dont la sépulture fut établie sur son domaine, à distance du chef-lieu. L’ensemble de la famille fait l’objet d’une présentation à caractère mémoriel. Le personnage principal a suivi la carrière des honneurs, associant une carrière municipale et une carrière équestre. La curatelle du templum divi Augusti à Narbonne traduit la réaction de la cité à l’annonce de la mort du prince. La carrière se prolonge par de plus hautes fonctions qu’il n’est pas possible de définir précisément. Le rapprochement avec une inscription de Cuers, colonie d’Arles (AE , 1999, 1016), permet d’envisager le rôle qu’aurait par la suite tenu cet important édifice religieux de la capitale provinciale.
Assistência de enfermagem no manejo de lesão por pressão (LP) na atenção domiciliar: um relato de experiência
Authors: Lima Fabrício Fernandes da Silva , Martins Emanoel Rodrigues , Silva Andrews Martins da , Ferreira Ana Cristynna Maciel , Roque Geusiane Souza , Costa Izabella Braga da , Lima Liwcy Keller de Oliveira Lopes , Saraiva Adriana Paiva Camargo
Published: February 2025

As Lesões por Pressão (LPs) afetam a recuperação do paciente, prolongando o tempo de hospitalização e elevando o risco para o desenvolvimento de infecções. Nesse sentido, o acompanhamento contínuo no ambiente domiciliar é um fator essencial no processo de recuperação do paciente. Este estudo objetiva relatar a experiência em uma atividade integrada em saúde, que iniciou com a observação da realidade local e culminou com estratégias para efetivação dos cuidados e prevenção de lesões por pressão no âmbito domiciliar. Para tanto, procedeu-se às etapas do Arco de Maguerez, no qual consiste na observação da realidade, pontos-chave, teorização, hipótese de solução e aplicação na realidade. Tais etapas foram realizadas no período de outubro a dezembro de 2024, junto a equipe do Programa Melhor em Casa (PMeC), no município de Conceição do Araguaia-PA. Desse modo, observa-se que, diante da problemática evidenciada, foi possível elaborar a estratégia de intervenção para solucionar as lacunas apontadas no cuidado ofertado. Por meio da elaboração de um folder e orientações sobre os cuidados que devem ser adotados nos casos de LP, foi possível levar informações úteis que devem auxiliar os cuidadores e os pacientes a adotar medidas para prevenção e manejo adequado das lesões. Permite-se concluir que a experiência vivenciada durante a aplicação do Arco de Maguerez contribuiu para uma compreensão mais abrangente dessa problemática e de suas implicações na qualidade de vida, viabilizando a disseminação de informações de maneira acessível e esclarecedora para o público em questão.
Torsemida versus Furosemida no tratamento da insuficiência cardíaca: uma revisão sistemática
Authors: Ferrari João Pedro de Assis , Dias Emanuele , Moura Adriano Soler de , Souza Fernanda Hanisch Tilgner de , Kapronezai Karoline , Macedo Luiz Felipe Amorim
Published: February 2025

A insuficiência cardíaca (IC) é uma comorbidade altamente prevalente, associada a elevada morbidade, mortalidade e um significativo impacto econômico global. A furosemida é o diurético de escolha para alívio dos sintomas decorrentes da sobrecarga de volume em pacientes com IC, no entanto, evidências recentes apontam para possíveis benefícios da torsemida nesse contexto. Esta pesquisa consiste em uma revisão sistemática da literatura na base de dados MEDLINE/PubMed de estudos clínicos randomizados entre janeiro de 2014 e dezembro de 2024. A evidência atual não sustenta uma vantagem clara da torsemida sobre a furosemida na redução da mortalidade ou hospitalização em pacientes com IC. Embora algumas análises sugiram benefícios potenciais da torsemida, especialmente em relação à redução de hospitalizações e possível efeito antifibrótico tardio, esses achados não são consistentes entre os estudos. A heterogeneidade da população estudada, as diferenças nos perfis clínicos dos pacientes e as limitações metodológicas indicam a necessidade de mais ensaios clínicos robustos para esclarecer o papel diferencial da torsemida na IC.
Espectro Autista em mulheres e meninas: um olhar sobre as diferenças de gênero e os desafios no diagnóstico
Authors: Nascimento Vanessa Heloise da Silva , Krepischi Ana Carolina , Lino Danilo Longhini , Araujo Camila Assis de , Micali Lara Dillela , Valério Arthur Gregório , Moreira Lais Teixeira , Cardoso Andreia Santos
Published: February 2025

O transtorno do Espectro Autista (TEA) é uma condição do neurodesenvolvimento, que faz parte de um grupo fenotipicamente heterogêneo de síndromes neuroevolutivas, com hereditariedade poligênica que se caracteriza pelo déficit de interação social, comunicação além de bases comportamentais repetitivas e interesses restritos. Desde o início dos estudos clínicos no mundo, o sexo não era considerado uma variável biológica. Estudos históricos indicam que o autismo tem sido diagnosticado com maior frequência em meninos e homens, embora evidências recentes sugiram que mulheres e meninas possam estar subdiagnosticadas. Isso porque ocorrem diferenças na manifestação sintomática exibida entre os gêneros, o que impacta essencialmente no reconhecimento clínico e no impacto social e terapêutico. É de suma importância reconhecer a necessidade de investigar as particularidades do autismo feminino, para que haja um olhar mais fundamentado a fim de conduzir melhor qualidade de vida da mulher autista
Desafios: insights de um aplicativo de saúde e bem-estar
Authors: Pagotto Fernanda , Antunes Carlos , Ramirez Leticia , Barbosa Lívia , Tanizaki Livia , Alves Bárbara Shibuya , Caldeira Patrícia , Tarifa Alexandre , Pimentel Carolina
Published: February 2025

Os aplicativos de saúde incentivam comportamentos saudáveis ao oferecerem conteúdos acessíveis e comunidades online. Os desafios temáticos foram criados para aumentar a retenção e engajamento. Objetiva-se avaliar engajamento na jornada de saúde e retenção dos usuários de um aplicativo de saúde que participaram de desafios temáticos. Para tanto, procedeu-se à realização de 4 desafios com duração de 14 dias no aplicativo de saúde, que apresentavam aos usuários conteúdos e estimulavam ações como interações em comunidades, acesso aos cardápios, exercícios físicos e meditação.  Foram realizadas estatísticas descritivas e testadas hipóteses entre os grupos. A média de usuários inscritos em desafios foi de 1.403 e em torno de 28.548 usuários que não estavam inscritos no mesmo período em média. O primeiro desafio implementado apresentou a maior diferença de retenção (z = 24,27), seguido pelo último desafio implementado (z = 22,31). O terceiro desafio apresentou a terceira maior diferença entre os grupos (z = 20,94) seguido pelo segundo desafio (z = 2,86). Em relação às ações de engajamento, nas interações nas comunidades foi observado que os usuários do desafio apresentaram maior engajamento (M = 105,71; DP = 32,7) do que os que não estavam no desafio (M = 44,16; DP = 16,81). O que permite concluir que os desafios deste aplicativo de saúde mostraram-se eficazes para aumentar a retenção e o engajamento nas ações de interação entre usuários que estão na mesma jornada de temática de saúde quando comparados com os usuários que não participaram dos desafios.
Embolização de artérias uterinas para tratamento de sangramento uterino anormal em adolescente: relato de caso
Authors: Rodrigues Rafaell Augusto Viana , Themótheo Florice de Matos , Nunes Paulo Henrique Silva , Filho Frederico Augusto de Carvalho Linhares
Published: February 2025

Introdução: Sangramento uterino anormal (SUA) é definido como sangramento do corpo uterino que é anormal em duração, volume, frequência e/ou regularidade. Devido à imaturidade do eixo hipotálamo-hipófise-ovário, o SUA é comum em adolescentes. Relato de caso: Paciente feminina, 14 anos, há 12 meses com ciclo menstrual de maior fluxo e duração associado a vertigens e dores em baixo ventre de forte intensidade. Histórico ginecológico: Menarca aos 10 anos; nega sexarca. Ultrassonografia pélvica mostrou útero volumoso aumentado, contornos e ecotextura miometrial normais; eco endometrial heterogêneo; espessado medindo 15 mm; histeroscopia sem alterações, apenas endometrite crônica. Realizado tratamento clínico com gestodeno e etinilestradiol (60mg/dia) associado a ácido tranexâmico. Evoluindo com melhora parcial da dor nos últimos 04 meses, no entanto mantendo ciclo menstrual volumoso. Foi avaliada por cirurgião vascular que indicou embolização de artérias uterinas (EAU), realizada sem intercorrências.
Abordagens clínicas no atendimento de urgência e emergência a clientes grávidas vítima de traumas
Authors: Jucá Luana de Almeida , Santos André Ramos dos , Filho João Murilo P. Ramos , Silveira Adriane Matoso da , Souza João Paulos dos Santos , Oliveira Ana Paula Rodrigues de , Vila Ana Caroline de Oliveira , Morais Paula Francinet de
Published: February 2025

Introdução: Este estudo aborda as intervenções clínicas em emergências e urgências para gestantes vítimas de traumas, destacando a complexidade do atendimento, que exige a avaliação e o cuidado simultâneo da mãe e do feto. Objetivo: O objetivo deste estudo é analisar as publicações acadêmicas divulgadas entre 2015 e 2025 sobre intervenções clínicas em emergências e urgências para gestantes vítimas de traumas. Metodologia: A pesquisa foi conduzida por meio de uma revisão narrativa com base em publicações científicas publicadas entre 2015 e 2025, realizada no período de novembro de 2024 a janeiro de 2025. Ao todo, foram analisados 2.493 artigos, dos quais 8 foram considerados relevantes para a pesquisa. Resultados: A análise dos artigos revelou que o trauma durante a gravidez pode resultar em complicações graves, como hemorragias, ruptura uterina e sofrimento fetal. Além disso, identificou-se que a violência doméstica é uma causa significativa de trauma em gestantes, sendo necessário um enfoque cuidadoso e multidisciplinar no tratamento dessas pacientes. Conclusão: Embora o trauma em gestantes seja um tema frequentemente negligenciado, ele deve ser reconhecido como uma área crítica no atendimento de emergência, exigindo protocolos específicos e uma abordagem integrada entre as equipes de saúde.
Can congenital hypothyroidism still be a cause of confusion with Syndromic Intellectual Development Disorders?
Authors: Nogueira Guilherme Nobre , Estevam Izaberen Sampaio , Filho João Alberto Delmiro da Silva , Silva João Paulo Bandeira da , Ramos Gabriel Moreira de Lima , Lisboa Islânia Maria Anselmo , Chollet Gabriel Gomes de Araújo , Pessoa André Luiz Santos
Published: February 2025

Congenital hypothyroidism (CH) is a leading preventable cause of intellectual developmental disorders, with a prevalence of 1 in 2,000 to 1 in 4,000 newborns. Neonatal screening programs play a crucial role in early detection and prevention of long-term neurodevelopmental consequences. This article presents the case of a 6-year-old female patient with a history of delayed growth and neuropsychomotor development due to CH, exacerbated by poor adherence to levothyroxine treatment. The patient exhibited typical clinical features of CH, including short stature, muscular hypotonia, macroglossia, and syndromic facies. Laboratory results revealed significantly elevated TSH levels and low free T4, confirming CH. The differential diagnosis was also considered Beckwith-Wiedemann syndrome due to overlapping craniofacial characteristics and the group of mucopolysaccharidoses and mucolipidosis due to the infiltrated facial appearance. This case highlights the importance of early diagnosis, adherence to treatment, and rigorous follow-up to prevent severe neurocognitive and developmental deficits. The article further discusses the significance of the National Neonatal Screening Program in Brazil in detecting and managing CH, emphasizing the need for enhanced patient and family support in low socioeconomic contexts.
«Red lines» in administration and management of complex systems
Authors: Voronin Albert , Savchenko Alina
Published: February 2025

The problem of optimizing a control system for an object created to fulfill several purposes is considered. Such a system has limited resources, determined during the administration process, based on the real capabilities of the developer. When optimizing the system, it is necessary to take these restrictions into account without violating them. This explains the presence of so-called «red lines», approaching which is undesirable or completely unacceptable. The optimization problem contains optimization arguments that deliver the extremum to the objective function. The objective function is based on the concept of a nonlinear trade-off scheme, for which the «away from restrictions» principle is satisfied. The optimization problem is solved formally, without the direct participation of the decision maker (DM). We consider an object O, the state of which is determined by a set of values x1,x2,…xn from the admissible region X that make up the vector x={xi}ni=1∈X. An object pursues several goals, the degree of achievement of each of them is expressed by the corresponding criterion yk(k), k ∈[1,…,s].  The criteria form a vector y={yk(x) }si=1∈M. Area M is determined by restrictions ykkmaxkmin  obtained during the administration process. This is the analytical expression of «red lines». The optimization problem is to determine the arguments x1,x2,…xn by extremizing the objective function Y[y(x)]  Essentially, this function is a scalar convolution of the criteria vector y(x), reflecting the utility function of the decision maker when solving a specific optimization problem. Scalar convolution is the act of composing criteria. A criterion yk(x)  is a measure of the quality of functioning of object O in relation to the achievement of the k-th goal. If «more» means «better» then to improve quality this criterion must be maximized. Otherwise, the criterion is minimized. For definiteness, we consider the optimization problem with minimized quality criteria.
KEPEMIMPINAN KIAI PONDOK PESANTREN SALAFIYAH SYAFI’IYAH SUKOREJO TERHADAP TRANSFORMASI PENDIDIKAN ISLAM
Authors: Djuwairiyah Djuwairiyah , Jamil Asyraf Isyraqi , Kadir Fakhrul Adabi Abd
Published: February 2025

This study aims to analyze the role of Kiai leadership in transforming Islamic education at the Salafiyah Syafi'iyah Sukorejo Islamic Boarding School. The method used in this study is a qualitative approach with a case study research type. Data were collected through in-depth interviews with Kiai, Islamic boarding school administrators, students, direct observation, and documentation. Data analysis was carried out using thematic analysis techniques to identify the role of Kiai in directing, managing, and transforming the Islamic education system in Islamic boarding schools. The study results indicate that Kiai leadership at the Salafiyah Syafi'iyah Sukorejo Islamic Boarding School significantly influences the renewal of the education curriculum, teaching methods, and the development of Islamic boarding school facilities. Kiai plays a central role in maintaining the Salafi tradition while accommodating educational developments that are more relevant to the needs of the times. This transformation includes integrating moderate Islamic values, strengthening educational competencies, and adapting to technological advances in the learning process. This study concludes that Kiai leadership at Salafi Islamic boarding schools is crucial in maintaining the balance between tradition and modernity in Islamic education.
FAVREINA BABAI ISP. NOV., A NEW ANOMURAN MICROCOPROLITE FROM THE UPPER CRETACEOUS OF SOUTHEASTERN SPAIN
Authors: SCHLAGINTWEIT FELIX , TORROMÉ DIEGO
Published: February 2025

The new anomuran microcoprolite Favreina babai isp. nov. is described from the Late Cretaceous La Cañadilla Formation of the Southern Iberian range. Within the ichnogenus Favreina, the new ichnospecies is characterized as rod-shaped bodies with numerous (> 100) laterally grouped longitudinal canals of rounded transverse sections within the symmetry plane. The high number of these canals represents an unique feature within the (Late) Cretaceous record. The new microcoprolite occurs in wackestones with miliolids (among Vidalina hispanica Schlumberger) and ostracods of shallow-water carbonates ascribed to a near-coastal facies.
Environmental and economic efficiency of introduction of photoelectrical stations in Turkmenistan for water supply and sustainable development of remote settlements
Authors:   Turkmen State Institute of Architecture and Civil Engineering, Ashgabat, Turkmenistan, Penjiyev Ahmet Myradovich
Published: February 2025

The development of Turkmenistan is based on an approach to the careful use of existing natural resources, the introduction of modern environmentally friendly equipment and innovative technologies that comply with the UN sustainable development agenda. For the conditions of the Karakum desert, the issue of reorienting settlements and agricultural complexes to regional system autonomous power supply and water supply using heliotechnical systems is relevant. Instead of the usual construction of power transmission lines, water facilities, pipelines, roads, etc., these systems in the future will save millions of US dollars compared to the costs raised for their creation and implementation. The purpose of the present study was to assess the environmental and economic efficiency of the introduction of photoelectrical stations for the water supply of settlements without central power supply. It is noted that the environmental and economic effect of the introduction of 1 heliotechnical installation will amount to 12.0 tons of fuel in the amount of 6,000 US dollars. At the same time, the reduction in СО2 emissions will amount to 38.4 tons. This will improve the state of the environment and the social sphere of the settlements of the Karakum desert. The results of scenario options for calculating the operation of the photovoltaic station and the mobile diesel pump station are presented.
Etnomodelos da cultura gaúcha e a iniciação científica para Feiras de Ciências
Authors: Hartmann Angela Maria , De Freitas Jeruza Quintana Petrarca
Published: February 2025

As práticas e os artefatos produzidos por determinada cultura são denominados etnomodelos quando as representações desenvolvidas e compartilhadas pelos membros do grupo cultural são consistentes com o conhecimento científico. Nesse aspecto, a cultura gaúcha é rica em práticas e artefatos que podem ser objeto de estudo de natureza científica e educacional. Relatam-se neste artigo as atividades realizadas em um curso de extensão denominado Etno’s Pampa que teve por objetivo promover o desenvolvimento de competências de iniciação científica em estudantes e professores dos Anos Finais do Ensino Fundamental de oito municípios do Rio Grande do Sul. Os participantes desenvolveram projetos de pesquisa inspirados em etnomodelos da cultura gaúcha para serem apresentados em Feiras de Ciências. Ao avaliarem o curso, os participantes salientaram o desenvolvimento de habilidades investigativas e sua contribuição para o aprimoramento da capacidade de percepção e valorização do contexto cultural gaúcho.
Wkład dziewięciu pokoleń rodu Taylorów do polskiej kultury
Authors: Sroka Stanisław Tadeusz
Published: February 2025

Artykuł opisuje wkład przedstawicieli rodu Taylorów w budowanie kultury polskiej. Wywodząca się ze Szkocji rodzina Taylorów przybyła do Polski w XVII w. prawdopodobnie w poszukiwaniu lepszych warunków życia. Początkowo wyznania kalwińskiego, stopniowo przechodziła na katolicyzm i szybko się polonizowała, a kolejne jej pokolenia wnosiły coraz większy wkład w rozwój kulturalny i społeczny naszego kraju. Swoją obecność jej członkowie początkowo zaznaczyli przede wszystkim w służbie wojskowej, a od szóstego pokolenia także w dziedzinach prawa i ekonomii oraz w naukach ścisłych. Zasłużyli się też w czasach współczesnych, włączając się w przemiany społeczne i demokratyczne po przełomie politycznym 1989 r. w Polsce.
Konflikt tożsamościowy – geneza i charakterystyka zjawiska
Authors: Klimek Jordan
Published: February 2025

Zestawienie dwóch kategorii teoretycznych, tj. konfliktu i tożsamości, odzwierciedla zjawiska występujące w przestrzeni relacji społecznych, które – choć bywają zauważone „między wierszami” – to do tej pory nie zostały w naukach społecznych jednoznacznie zdefiniowane lub dookreślone. W artykule podjęto zatem próbę charakterystyki zjawiska konfliktu tożsamościowego. W szczególności dotyczy to określenia jego genezy, uwarunkowań, zakresu i konsekwencji. W wyniku krytycznej analizy literatury przedmiotu określono także poziomy konfliktu tożsamościowego. Wnioski wskazują między innymi, że konflikt tożsamościowy wymaga reakcji, czyli w pierwszej kolejności uświadomienia sobie problemu i jego źródła, a następnie ustosunkowania się do wartości kluczowej dla przedmiotu sporu tożsamościowego, tj. rezygnacji lub włączenia pewnych atrybutów tożsamościowych.
Literatura dziecięca jako iskra nadziei na zażegnanie konfliktów plemiennych w Zimbabwe
Authors: Dymel-Trzebiatowska Hanna
Published: February 2025

W artykule przypomniana jest historia krwawego, plemiennego konfliktu w Zimbabwe o nazwie Gukurahundi (1983–1987) ze szczególnym uwzględnieniem doświadczeń dzieci. Dzieci, które były ofiarami tej wojny, dziś jako dorosłe osoby nadal noszą ją w pamięci, ale również współczesne, najmłodsze pokolenie jest ofiarą obecnych w narodzie reperkusji Gukurahundi w postaci tzw. lingwistycznego ludobójstwa. W kontekście tych wciąż żywych antagonizmów zadane zostało pytanie, czy jedna z nielicznych na rynku zimbabweńskim współczesnych książek obrazkowych dla dzieci My First Book of Shona and Ndebele Words (Moja pierwsza książka ze słowami w shona i ndebele, 2021) stanowi iskrę nadziei na wychowanie nowego pokolenia, które położyłoby kres długoletniej etnicznej polaryzacji.
Drugim z kolejności środkiem zabezpieczającym jest ucieczka
Authors: Szymborski Wiktor
Published: February 2025

Celem niniejszego szkicu jest zwrócenie uwagi na interesujący sposób walki z zarazą/ czarną śmiercią, który przedsięwzięli dwaj dominikanie z wrocławskiego klasztoru w drugiej połowie XV w. Wedle rozporządzeń dominikańskich konstytucji zakonnicy nie powinni studiować medycyny, ale postępowanie dwóch braci wskazuje, że posiadali oni podstawową wiedzę z zakresu medycyny i znali ówczesne metody zapobiegania zarazie. Zakonnicy otrzymali specjalną zgodę władz zakonnych na opuszczenie konwentu w przypadku pojawienia się zarazy.
THE CELLULOSE FIBRE INDUSTRY: HARNESSING AGRICULTURAL WASTE FOR PRODUCTION
Authors:   Organic Chemistry Department, University of Córdoba, Marie Curie (C-3) Building, Crta. Nnal. km 396, E-14014 Córdoba, Spain, BELHAJ JIHENE , SERRANO LUIS ,   Inorganic Chemistry and Chemical Engineering Department, University of Córdoba,
Marie Curie (C-3) Building, Crta. Nnal. km 396, E-14014 Córdoba, Spain, KHIARI RAMZI ,   Department of Textile, Higher Institute of Technological Studies of Ksar Hellal,
Ksar Hellal 5070, Tunisia, GARCIA ARACELI ,   Organic Chemistry Department, University of Córdoba, Marie Curie (C-3) Building,
Crta. Nnal. km 396, E-14014 Córdoba, Spain
Published: February 2025

This article investigates the potential of using agricultural residues from almond (Prunus amygdalus L.) and fig (Ficus carica L.) plants as sustainable sources for cellulose production. The study outlines the comprehensive pretreatment processes employed to extract cellulose fibres from these residues. Initially, delignification was carried out using a straightforward soda process, followed by sodium chlorite bleaching to enhance fibre purity. Subsequently, an alkali treatment was applied to remove hemicelluloses, ensuring the isolation of cellulose. The extracted cellulose was characterized through advanced techniques, such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA). These methods confirmed the successful extraction and purity of the cellulose obtained from the agricultural waste materials. The results of the characterization processes revealed that the cellulose derived from almond and fig residues possesses suitable properties for various industrial applications. This includes the production of biomaterials, cellulose derivatives, and reinforced composite polymers. The findings underscore the potential of these agricultural residues as a valuable and renewable resource for cellulose production, contributing to the development of sustainable materials and promoting waste valorization in the agricultural sector.