bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanostructured Modifications of Titanium Surfaces Improve Vascular Regenerative Properties of Exosomes Derived from Mesenchymal Stem Cells: Preliminary In Vitro Results
Authors: Gardin Chiara , Ferroni Letizia , Erdoğan Yaşar Kemal , Zanotti Federica , De Francesco Francesco , Trentini Martina , Brunello Giulia , Ercan Batur , Zavan Barbara
Published: December 2021

(1) Background: Implantation of metal-based scaffolds is a common procedure for treating several diseases. However, the success of the long-term application is limited by an insufficient endothelialization of the material surface. Nanostructured modifications of metal scaffolds represent a promising approach to faster biomaterial osteointegration through increasing of endothelial commitment of the mesenchymal stem cells (MSC). (2) Methods: Three different nanotubular Ti surfaces (TNs manufactured by electrochemical anodization with diameters of 25, 80, or 140 nm) were seeded with human MSCs (hMSCs) and their exosomes were isolated and tested with human umbilical vein endothelial cells (HUVECs) to assess whether TNs can influence the secretory functions of hMSCs and whether these in turn affect endothelial and osteogenic cell activities in vitro. (3) Results: The hMSCs adhered on all TNs and significantly expressed angiogenic-related factors after 7 days of culture when compared to untreated Ti substrates. Nanomodifications of Ti surfaces significantly improved the release of hMSCs exosomes, having dimensions below 100 nm and expressing CD63 and CD81 surface markers. These hMSC-derived exosomes were efficiently internalized by HUVECs, promoting their migration and differentiation. In addition, they selectively released a panel of miRNAs directly or indirectly related to angiogenesis. (4) Conclusions: Preconditioning of hMSCs on TNs induced elevated exosomes secretion that stimulated in vitro endothelial and cell activity, which might improve in vivo angiogenesis, supporting faster scaffold integration.
Fluorescent Probes for STED Optical Nanoscopy
Authors: Jeong Sejoo , Widengren Jerker , Lee Jong-Chan
Published: December 2021

Progress in developing fluorescent probes, such as fluorescent proteins, organic dyes, and fluorescent nanoparticles, is inseparable from the advancement in optical fluorescence microscopy. Super-resolution microscopy, or optical nanoscopy, overcame the far-field optical resolution limit, known as Abbe’s diffraction limit, by taking advantage of the photophysical properties of fluorescent probes. Therefore, fluorescent probes for super-resolution microscopy should meet the new requirements in the probes’ photophysical and photochemical properties. STED optical nanoscopy achieves super-resolution by depleting excited fluorophores at the periphery of an excitation laser beam using a depletion beam with a hollow core. An ideal fluorescent probe for STED nanoscopy must meet specific photophysical and photochemical properties, including high photostability, depletability at the depletion wavelength, low adverse excitability, and biocompatibility. This review introduces the requirements of fluorescent probes for STED nanoscopy and discusses the recent progress in the development of fluorescent probes, such as fluorescent proteins, organic dyes, and fluorescent nanoparticles, for the STED nanoscopy. The strengths and the limitations of the fluorescent probes are analyzed in detail.
Phytic Acid and Whole Grains for Health Controversy
Authors: Brouns Fred
Published: December 2021

Phytate (PA) serves as a phosphate storage molecule in cereals and other plant foods. In food and in the human body, PA has a high affinity to chelate Zn2+ and Fe2+, Mg2+, Ca2+, K+, Mn2+ and Cu2+. As a consequence, minerals chelated in PA are not bio-available, which is a concern for public health in conditions of poor food availability and low mineral intakes, ultimately leading to an impaired micronutrient status, growth, development and increased mortality. For low-income countries this has resulted in communications on how to reduce the content of PA in food, by appropriate at home food processing. However, claims that a reduction in PA in food by processing per definition leads to a measurable improvement in mineral status and that the consumption of grains rich in PA impairs mineral status requires nuance. Frequently observed decreases of PA and increases in soluble minerals in in vitro food digestion (increased bio-accessibility) are used to promote food benefits. However, these do not necessarily translate into an increased bioavailability and mineral status in vivo. In vitro essays have limitations, such as the absence of blood flow, hormonal responses, neural regulation, gut epithelium associated factors and the presence of microbiota, which mutually influence the in vivo effects and should be considered. In Western countries, increased consumption of whole grain foods is associated with improved health outcomes, which does not justify advice to refrain from grain-based foods because they contain PA. The present commentary aims to clarify these seemingly controversial aspects.
SGC-CK2-1 Is an Efficient Inducer of Insulin Production and Secretion in Pancreatic β-Cells
Authors: Pack Mandy , Götz Claudia , Wrublewsky Selina , Montenarh Mathias
Published: December 2021

The pyrazolopyrimidine based compound SGC-CK2-1 is a potent and highly specific CK2 inhibitor and a new tool to study the biological functions of protein kinase CK2 irrespective from off-target effects. We used this compound in comparison with the well-established CK2 inhibitor CX-4945 to analyze the importance of CK2 for insulin production and secretion from pancreatic β-cells. Both inhibitors affected the proliferation and viability of MIN6 cells only marginally and downregulated the endogenous CK2 activity to a similar level. Furthermore, both inhibitors increased the message for insulin and boosted the secretion of insulin from storage vesicles. Thus, regarding the high specificity of SGC-CK2-1, we can clearly attribute the observed effects to biological functions of protein kinase CK2.
Patterns and Predictors of Off-Label Drug Prescribing in Psychiatric Practice: A Qualitative Study
Authors: Shakeel Sadia , Nesar Shagufta , Rehman Hina , Jamil Khizra , Mallick Imran Ahsan , Mustafa Muhammad Shahid , Anwar Mudassir , Jamshed Shazia
Published: December 2021

Off-label drug prescribing (OLDP) must be based on strong scientific evidence to make sure that patients get the optimum therapeutic outcomes. Adherence to the prerequisites is determined by the physicians’ attitude and knowledge. In this context, the present study was conducted with the goal of investigating psychiatrists’ perceptions of the use of OLDP in their clinical practice. A total of 14 psychiatrists were interviewed using a semi-structured interview guide. Thematic content analysis was performed. Data saturation was achieved at the 12th interview. Six major themes and fifteen subthemes emerged from qualitative interviews. Among the major themes were knowledge and concepts about the off-label drugs, attitude and current practice of prescribing off-label drugs, and rationale of prescribing and suggestions for reducing the use of off-label drugs. Almost all of the respondents interviewed provided detailed comments concerning the OLDP concept, depicted an optimistic approach and deemed that OLDP is quite common in psychiatry. Off-label usage of benzodiazepines such as clonazepam, diazepam and lorazepam in mania, depression, and obsessive–compulsive disorder were commonly reported. It was observed that the majority of the respondents did not inform the patients before prescribing off-label drugs. The present findings revealed that respondents had awareness; however, they depicted diverse attitudes towards prescribing off-label drugs. Further education and sensitization in regions with impoverished knowledge would certainly assist in preventing the risks associated with the use of OLDP.
Optical Design of a Quantitative Microvolume Nucleic Acid Spectrophotometer with Non-Optical Fiber and All Radiation-Hardened Lens Elements
Authors: Lin Sheng-Feng
Published: December 2021

The purity of the nucleic acid samples obtained by extraction/precipitation or adsorption chromatography must be verified with microvolume spectrophotometry to ensure a high success rate of the subsequent nucleic acid sequencing while exploring the trace rare nucleic acids in space exploration with in-situ life detection. This paper reports an optical design for a radiation-hardened quantitative microvolume spectrophotometer with all radiation-hardened lens elements for space exploration instruments by using a non-optical fiber optical path with radiation-hardened optical glass elements. The results showed that the mean absolute error rate of the measured standard ribonucleic acid samples at concentrations between 50 ng/μL and 2300 ng/μL was within 2% when compared with a LINKO LKU–6000 ultraviolet–visible spectrophotometer.
Effect of the Glass Fiber Content of a Polybutylene Terephthalate Reinforced Composite Structure on Physical and Mechanical Characteristics
Authors: Hamlaoui Oumayma , Klinkova Olga , Elleuch Riadh , Tawfiq Imad
Published: December 2021

This work presents the influences of glass fiber content on the mechanical and physical characteristics of polybutylene terephthalate (PBT) reinforced with glass fibers (GF). For the mechanical characterization of the composites depending on the GF reinforcement rate, tensile tests are carried out. The results show that increasing the GF content in the polymer matrix leads to an increase in the stiffness of the composite but also to an increase in its brittleness. Scanning Electron Microscope analysis is performed, highlighting the multi-scale dependency on types of damage and macroscopic behavior of the composites. Furthermore, flammability tests were performed. They permit certifying the flame retardancy capacity of the electrical composite part. Additionally, fluidity tests are carried out to identify the flow behavior of the melted composite during the polymer injection process. Finally, the cracking resistance is assessed by riveting tests performed on the considered electrical parts produced from composites with different GF reinforcement. The riveting test stems directly from the manufacturing process. Therefore, its results accurately reflect the fragility of the material used.
Accurate Electroadhesion Force Measurements of Electrostrictive Polymers: The Case of High Performance Plasticized Terpolymers
Authors: Fimbel Amaury , Abensur Thierry , Le Minh-Quyen , Capsal Jean-Fabien , Cottinet Pierre-Jean
Published: December 2021

Electroadhesion is a phenomenon ruled by many characteristic intrinsic parameters. To achieve a good adhesion, efficient and durable, a particular attention must be provided to the adhesion forces between the involved parts. In addition to the size and geometry of electrodes, parameters of materials such as dielectric constant, breakdown electric field, and Young’s modulus are key factors in the evaluation of electroadhesion efficiency for electrostrictive polymers and electroactive devices. By analyzing these material parameters, a method is proposed to justify the choice of polymer matrices that are fit to specific electroadhesion applications. Another purpose of this work aims to demonstrate a possibility of accurately measuring the electroadhesion force. This physical parameter has been usually estimated through equations instead, because of the complexity in setup implementation to achieve highly precise measure. Comparisons based on the parameters criterion reveal that besides the intrinsic properties of material, some other parameters relating to its physical phenomena (e.g., saturation of dipolar orientation under high electric field leads to decrease dielectric constant), or physical behavior of the system (i.e., surface roughness reduces the active electrode area) must be thoroughly considered. Experimental results pointed out that plasticized terpolymer leads boosted electroadhesion performance compared to the other counterparts, up to 100 times higher than conventional polymers. The developed materials show high potential in applications of active displacement control for electrostrictive actuation.
Influence of Commonly Used Endodontic Irrigants on the Setting Time and Metal Composition of Various Base Endodontic Sealers
Authors: Jose Jerry , Teja Kavalipurapu Venkata , Ranjan Manish , Mohamed Roshan Noor , Alam Mohammad Khursheed , Shrivastava Deepti , Natoli Valentino , Nagarajappa Anil Kumar , Janani Krishnamachari , Srivastava Kumar Chandan
Published: December 2021

The present study aimed to evaluate if commonly used endodontic irrigants such as 3% sodium hypochlorite (NaOCl, Prime Dental, Thane, India), 2% chlorhexidine (CHX, Sigma-Aldrich Co., St. Louis, MO, USA), and 17% ethylenediaminetetraacetic acid (EDTA, Meta-Biomed Co. Ltd., Cheongju-si, South Korea) influenced the setting time and metal composition of different base endodontic sealers on exposure. AH Plus (Dentsply De Trey GmbH, Konstanz, Germany), Sealapex (SybronEndo, Orange, CA, USA), mineral trioxide aggregate (MTA) Fillapex (Angelus Soluções Odontológicas, Londrina, Brazil), and Tubli-Seal (Kerr Dental, Orange, CA, USA) were selected as the different base representatives of endodontic sealers. These sealers were exposed to 3% NaOCl, 2% CHX, and 17% EDTA, and the individual setting time of the sealers was analyzed. The samples were analyzed for heavy metal elements such as chromium (Cr), nickel (Ni), cobalt (Co), cadmium (Cd), arsenic (As), mercury (Hg), lead (Pb), and beryllium (Be) by using inductively coupled plasma mass spectrometry (ICP-MS) analysis. For statistical analysis, one-way ANOVA and post hoc Tukey’s tests were used. All selected sealers showed variation in setting time post-exposure to different irrigants. MTA Fillapex had the shortest mean setting time (215.7 min, post-exposure at 187.3 min) (p < 0.05). Mean setting time was also affected for AH Plus (479.6 min, post-exposure at 423.9 min) (p < 0.05) and Tubli-Seal (514.7 min, post-exposure at 465.2 min) (p < 0.05). Sealapex showed the maximum reduction of setting time (864.8 min, post-exposure at 673.4 min) (p < 0.05). All tested sealers showed heavy metals (Cr, Ni, Co, Cd, As, Hg, and Pb) in their composition, and the quantities were influenced by interaction with different irrigants. The heavy metal Be was not seen in any of the samples. Sealapex showed the longest setting time in comparison to other test sealers. Heavy metals were most present in Sealapex, followed by AH Plus, Tubli-Seal, and MTA Fillapex. MTA Fillapex was seen to have the shortest setting time, and heavy metal composition was least affected on interaction with different commonly used endodontic irrigants. Further, this study provides significant insight into the influence of different endodontic irrigants on interaction with different base endodontic sealers, which has not been reported previously, and future studies should emphasize endodontic irrigant-sealer interactions and their possible effects in the long run.
Pomegranate Fruit Quality and Seed Drying Method: Effect on the Chemical Composition and Bioactivities of the Extracted Oil
Authors: Fawole Olaniyi Amos , Kaseke Tafadzwa , Opara Umezuruike Linus
Published: December 2021

The study presents a comparative investigation of the composition and bioactivity of oil extracted from pomegranate seeds of sun-burned fruit (SB) and healthy fruit (HF) for the value-adding potential of pomegranate fruit waste. Seeds from SB and HF were independently freeze dried, sun dried, and oven dried before ultrasound-assisted oil extraction using petroleum ether. The extracted oil was analysed for yield, refractive index, ρ-anisidine value, total phenolic content (TPC), DPPH radical scavenging ability, antimicrobial activity, tyrosinase enzyme inhibition ability, and fatty acid composition. The results showed that oven dried seeds, regardless of fruit quality, yielded the highest oil (20.85–24.70%, dry weight). Regardless of the seed drying method, oil from the seeds of SB exhibited the highest TPC (1.48–2.84 mgGAE/g PSO) than oil from the seeds of HF. The oil from oven dried and freeze dried seeds of SB were more effective in scavenging the DPPH radicals with IC50 values of 34.77 and 39.97 µg/mL, respectively. All the oil samples showed good ability to inhibit tyrosinase enzyme regardless of fruit quality and seed drying method, with monophenolase and diphenolase IC50 ranging between 0.31 and 0.49 mg/mL and 0.64 and 2.43 mg/mL, respectively. Irrespective of the drying method, oil extracted from HF seeds exhibited greater antimicrobial potency against the tested bacteria. The fatty acid composition of the oil samples was neither affected by fruit quality and seed drying method. Generally, all oil samples exhibited high levels of punicic acid (81.21–82.68%) and low omega 6 to omega 3 ratios (0.19–0.37%), suggesting that the oil samples were healthy. Principal component analysis (PCA) established that freeze dried seeds of SB is an excellent source of oil with higher TPC, punicic acid, polyunsaturated fatty acids, and unsaturated fatty acid/saturated fatty acid ratio. It can be concluded that the seed from SB is a good raw material for oil that can be utilised in cosmetic products formulation.
Biogenic Amine Content in Retailed Cheese Varieties Produced with Commercial Bacterial or Mold Cultures
Authors: Zdolec Nevijo , Bogdanović Tanja , Severin Krešimir , Dobranić Vesna , Kazazić Snježana , Grbavac Jozo , Pleadin Jelka , Petričević Sandra , Kiš Marta
Published: December 2021

Biogenic amines (BAs) are considered a potential microbiological toxicological hazard in aged cheese. Risk mitigation strategies include good hygiene practice measures, thermal treatment of milk and the use of competitive dairy cultures. The aim of this study was to evaluate the amount of BAs—tryptamine, β-phenylethylamine, putrescine, cadaverine, histamine, tyramine, spermidine and spermine—in the core and rind of cheeses ripened by bacteria (n = 61) and by mold cultures (n = 8). The microbial communities were counted, and the dominant lactic acid bacteria (LAB) were identified, corresponding to the BA concentrations. The total BA content was highest in the core of semi-hard cheeses (353.98 mg/kg), followed by mold cheeses (248.99 mg/kg) and lowest in hard cheeses (157.38 mg/kg). The highest amount of BAs was present in the rind of cheeses with mold (240.52 mg/kg), followed by semi-hard (174.99 mg/kg) and hard cheeses (107.21 mg/kg). Tyramine was the most abundant BA, represented by 75.4% in mold cheeses, 41.3% in hard cheese and 35% of total BAs in semi-hard cheeses. Histamine was present above the defined European maximum level (ML) of 100 mg/kg in only two semi-hard and three hard cheeses. High amount of BAs (above 600 mg/kg) in cheeses, mainly tyramine, were associated with the presence of Enterococcus durans, while negligible BA concentrations were found in cheeses ripened with Lacticaseibacillus rhamnosus, Lactococcus lactis or Lacticaseibacillus paracasei cultures. This study has shown that retailed cheese varieties produced with commercial bacterial or mold cultures have acceptable levels of biogenic amines with respect to consumers.
Design of Position Control Method for Pump-Controlled Hydraulic Presses via Adaptive Integral Robust Control
Authors: Huang Zhipeng , Xu Yuepeng , Ren Wang , Fu Chengwei , Cao Ruikang , Kong Xiangdong , Li Wenfeng
Published: December 2021

This paper takes the position control performance of pump-controlled hydraulic presses as the research object. The control methods are designed respectively for the two motion stages of rapid descent and slow descent of hydraulic presses in order to improve the control performance of the system. First of all, the accuracy model of the pump-controlled hydraulic presses position servo system (the pump-controlled hydraulic presses position servo system, which is called PCHPS) and its MATLAB/Simulink simulation platform are established. Based on the theoretical analysis and experimental data, the interference factors affecting the tracking accuracy and positioning accuracy of the PCHPS are analyzed. Then, an adaptive integral robust control (the adaptive integral robust control, which is called AIRC) for PCHPS is designed to reduce the influence of nonlinear factors on the system, and the effectiveness of the controller is verified by simulation. Finally, the position control experiment of PCHPS is designed, and the experimental results show that the AIRC can effectively reduce nonlinear factors such as unknown interference in the slow-down stage of the system. The positioning accuracy is raised to within 0.008 mm, which improves the process level of the hydraulic presses.
Oil Recovery from Dry Grind Ethanol Plant Coproducts Using Ethanol
Authors: Huda Md. Sanaul , Nahar Nurun
Published: December 2021

Corn ethanol bio-refineries are seeking economic processing strategies for recovering oil from their coproducts. The addition of ethanol can be an efficient method to recover the oil from the coproducts as the industry has available ethanol. This study considered the effects of ethanol on oil recovery from distillers’ dried grains with solubles (DDGS) and oil partitioning from whole stillage (WS) on a laboratory scale. Ethanol was added with original and heavier fraction DDGS in different temperatures (room temperature ~20 °C, 30 °C, 40 °C, and 50 °C) and solids loadings (20%, 30%, and 40%), and their effects on oil recovery were evaluated. The whole stillage was incubated with ethanol at room temperature (~20 °C) and 50 °C separately to analyze WS’s oil distribution in the liquid and solid phases. The amount of recovered oil from the original and heavier fractions of DDGS varies from 25–45% and 45–70%, respectively, with an increment of temperature. Increasing solids loadings up to 30% had no effect on oil recovery from either DDGS sample. Ethanol treatment in WS resulted in 8–10% higher wet yield of liquid fraction and 17–20% of oil increase in liquid fraction than the control treatment. It is also notable that temperature positively impacted oil partitioning from WS. The results showed that ethanol could improve oil recovery from DDGS and oil partition in WS by varying different process conditions. This outcome is beneficial to ethanol plants to increase corn oil yield using their existing setup and in-situ product.
Separation Characteristics of an Axial Hydrocyclone Separator
Authors: Kou Jie , Jiang Zhaoming , Cong Yiying
Published: December 2021

An innovative axial hydrocyclone separator was designed in which a guide vane was installed to replace a conventional tangential inlet, potentially aggravating inlet turbulence. The characteristics of velocity distribution, concentration distribution, and pressure distribution inside the separator were obtained through the numerical simulation of the turbulent flow of oil and water. The results showed that the flow field presented good symmetry, which eliminated the eccentric turbulence phenomenon in the conventional hydrocyclone separators and was beneficial for the oil–water separation.
What Role Does Religion Have in Shaping Human Consumption?
Authors: He Yugang , Wang Yinhui , Gao Xiaodan
Published: December 2021

Religious belief, as an informal social institution, has a significant impact on all aspects of human civilization. Previous literature has studied the effects of religious belief on economic growth, income, education, etc. Therefore, using the case of China as an example, this paper aims to investigate the effect of religious belief on human consumption. An empirical review of cross-sectional data from China’s 28 provinces reveals that religious belief has a detrimental impact on human consumption. Meanwhile, two-stage least squares and substituting the dependent variable (hc2) are employed to perform robustness tests. The new results also support the conclusion that religious belief negatively affects human consumption. In addition, this paper also discusses the heterogeneous effect of religious belief on human consumption in terms of geographical location, income level, and marketization degree. The results demonstrate the existence of the heterogeneous effect. Specifically, in the western area, low income level, and low marketization degree, religious belief negatively affects human consumption the most. On the contrary, in the eastern area, high income level, and high marketization degree, religious belief negatively affects human consumption the least.
Validity of the AdMos, Advanced Sport Instruments, GNSS Sensor for Use in Alpine Skiing
Authors: Jølstad Petter Andre Husevåg , Reid Robert Cortas , Gjevestad Jon Glenn Omholt , Gilgien Matthias
Published: December 2021

The AdMos receiver from Advanced Sport Instruments is a global navigation satellite system (GNSS) frequently used in alpine ski racing, with users from national and professional teams. Therefore, a validation was conducted for use of the AdMos in alpine skiing, using data from both recreational and competitive skiers. Athletes skied a total of 60 km in different measurement and skiing conditions, while carrying both an AdMos and a differential GNSS, which was used as the gold standard. From the GNSS position data, speed, acceleration, turn radius, trajectory incline and impulse were calculated as instantaneous and turn average measures for both GNSS systems and errors between the systems were calculated. The median and interquartile range (IQR) for the instantaneous errors were below 3.5 (3.5) m for horizontal plane position and below 7.0 (4.3) m for the 3D position. The median and IQR for instantaneous errors and turn average errors, respectively, were below 0.04 (0.24)/0.04 (0.16) m/s for speed, below 0.23 (1.06)/0.35 (0.63) m/s2 for acceleration, below 0.47 (5.65)/0.73 (5.3) m for turn radius, and below 0.043 (1.96)/0.42 (1.42) degrees for trajectory incline. The median and IQR for turn average impulse were 0.025 (0.099) BWs. The position error changed gradually and randomly over time, with low noise levels causing smooth trajectories of similar shape but spatially shifted from the true trajectory that allowed the position–time derivation of the performance parameters, and detection of turns with 3% median and 5% IQR error. The accuracy assessment revealed that (1) the error levels were comparable to other consumer-grade standalone GNSS units designed for sport; (2) the trajectories closely resembled the true trajectories but with a random shift that changed over time and had a low noise level; (3) there was a very low instantaneous speed error that may allow the detection of many performance aspects of skiing and other sports; and (4) there were larger instantaneous errors for the remaining performance parameters, which decreased substantially when averaged over a turn.
Forward-Looking Super-Resolution Imaging for Sea-Surface Target with Multi-Prior Bayesian Method
Authors: Li Weixin , Li Ming , Zuo Lei , Sun Hao , Chen Hongmeng , Li Yachao
Published: December 2021

Traditional forward-looking super-resolution methods mainly concentrate on enhancing the resolution with ground clutter or no clutter scenes. However, sea clutter exists in the sea-surface target imaging, as well as ground clutter when the imaging scene is a seacoast.Meanwhile, restoring the contour information of the target has an important effect, for example, in the autonomous landing on a ship. This paper aims to realize the forward-looking imaging of a sea-surface target. In this paper, a multi-prior Bayesian method, which considers the environment and fuses the contour information and the sparsity of the sea-surface target, is proposed. Firstly, due to the imaging environment in which more than one kind of clutter exists, we introduce the Gaussian mixture model (GMM) as the prior information to describe the interference of the clutter and noise. Secondly, we fuse the total variation (TV) prior and Laplace prior, and propose a multi-prior to model the contour information and sparsity of the target. Third, we introduce the latent variable to simplify the logarithm likelihood function. Finally, to solve the optimal parameters, the maximum posterior-expectation maximization (MAP-EM) method is utilized. Experimental results illustrate that the multi-prior Bayesian method can enhance the azimuth resolution, and preserve the contour information of the sea-surface target.
Effect of Moisture Content on Calculated Dielectric Properties of Asphalt Concrete Pavements from Ground-Penetrating Radar Measurements
Authors: Cao Qingqing , Al-Qadi Imad L.
Published: December 2021

Moisture presence in asphalt concrete (AC) pavement is a major cause of damage to the pavement. In recent decades, an increasing need exists for non-destructive detection and monitoring of the moisture content in AC pavement. This paper provides a simulated approach to quantify the effect of internal moisture content on AC pavement dielectric properties using ground-penetrating radar (GPR). A heterogeneous numerical model was developed to simulate AC pavement with internal moisture at various saturation levels. The numerical model was validated using GPR surveys on cold-in-place recycling treated pavements. An empirical formula was derived from the simulation to correlate the dielectric constant with the moisture content for non-dry AC pavement. The results validated the proposed model and, hence, demonstrated the ability of GPR to monitor moisture variation in AC pavements.
Using Metabolite Data to Develop Patient Centric Specification for Amide Impurity in Vildagliptin Tablets
Authors: Charoo Naseem Ahmad , Untoo Syeed , Rahman Ziyaur
Published: December 2021

Many specified impurities in vildagliptin’s finished product have been disclosed in the literature that are above their qualification threshold. We used the impurity B (amide impurity) as a case example to explore whether existing literature can be leveraged to determine the safe level of impurity and thereby develop a patient-centric specification (PCS) for impurities. No-observed-adverse-effect level (NOAEL) was derived from rate metabolism information and converted to human equivalent dose (HED). The HED was estimated as 6.5 mg/day. The high qualification levels are supported by repeat dose toxicity studies performed in rats, mice and dogs. Maximum theoretical amount (MTA) was correlated with the maximum observed amount (MOA) to verify whether the exposure was due to impurity and/or metabolite. MOA/MTA was found ≥1 suggesting that metabolism contributed to the amount excreted in feces and therefore could be used to further justify a higher specification limit than the usual one of ≤0.5%. Quite often the drug metabolism and degradation pathways overlap, resulting in the formation of identical constituents. Therefore, metabolism data can be leveraged for deriving safe levels of degradation impurities and develop PCS for impurities.
The Impacts of Urbanisation on Landscape and Environment: The Case of Slovakia
Authors: Izakovičová Zita , Petrovič František , Pauditšová Eva
Published: December 2021

The development of urbanisation is linked to qualitative and quantitative changes in the landscape and its components aimed at strengthening economic, administrative and cultural-social functions, which are associated with ever-increasing pressures on ecosystems and their individual components. These pressures are subject to various factors—socio-economic, political, environ-mental, etc. In this paper, we present an evaluation of the environmental impacts of the development of urbanisation in Slovakia. Independent Slovakia belongs to the young European states. The communist period lasted from 1948 to 1989. The character of landscape, the quality of the environment and also the degree of anthropisation of territory were dependent on a centrally managed economy. Urbanisation changes began to manifest themselves rapidly after 2000, when the economy was transformed and Slovakia was preparing to join the European Union (Slovakia joined the European Union in 2004). The transformation from central planning into a market economy was the basis of the changes, which was conditioned following strong pressure of investors on the landscape, the construction of technological parks, shopping and logistics centres and transport infrastructure and the construction of residential complexes. According to the European Environment Agency’s study on urban sprawl between the mid-1950s and the end of the 1990s, industry, commercial and transport services have grown at a significant rate and the residential areas at a moderate rate in Slovakia. On the other hand, Slovakia has areas where urbanisation has the opposite trend. Rural settlements are abandoned as well as large areas of agricultural land. The character of land use has fundamentally changed over the past 20 years. These changes not only have a spatial dimension but are associated with the emergence of various environmental problems. The paper deals with the impacts of anthropisation and industrialisation of Slovakia after 2000. The anthropisation process in Slovakia was determined through data processed in GIS and also through the statistical data representing land use. Based on the ecological significance of land use elements, the degree of anthropisation in Slovakiawas calculated.
Transformation and Sustainable Development of Shopping Centers: Case of Czech and Slovak Cities
Authors: Križan František , Kunc Josef , Bilková Kristína , Novotná Markéta
Published: December 2021

The aim of the paper is to critically evaluate the similarities and differences in the development of the temporal and spatial structure of shopping centers in the Czech and Slovak republics. We focused on the retail transformation and sustainable manifestations of the location and construction of shopping centers. We classified shopping centers according to their genesis, location in the city, and size of the gross leasable area. To analyze migration trends and geographic distribution characteristics of shopping centers in the capital cities of both countries (local level of analysis), we used spatial gravity and standard deviational ellipse. Generally, there is an analogous trend in the development of shopping centers in the Czech Republic and Slovakia, with a particular two- to four-year lag in Slovakia (west–east gradient). Despite this, we still perceive the demand for shopping centers in both countries as above average, and it is not declining. The construction of shopping centers, mainly in small towns, also indicates this trend. In Prague and Bratislava, the pattern of spatial expansion of shopping centers differs. Prague probably represents a more advanced phase of shopping center agglomeration. However, neither country has reached the state of clustering.
Water Management in Agriculture and Industry: Challenges, Trends, and Opportunities
Authors: Aivazidou Eirini
Published: December 2021

This Special Issue aims to explore current challenges and trends, as well as opportunities for sustainability and innovation, in the fields of agricultural and industrial water management [...]
Comprehensive Evaluation of Functional Diversity of Urban Commercial Complexes Based on Dissipative Structure Theory and Synergy Theory: A Case of SM City Plaza in Xiamen, China
Authors: Qin Yuchen , Yao Minfeng , Shen Lan , Wang Qichen
Published: December 2021

Urban commercial complex is an architectural form formed in the high-density urban building environment based on the diversified concentration of human consumption behavior and the composite utilization of space. It can effectively cope with the problem of tight land resources and insufficient development capacity in urban centers and promote sustainable urban development. Additionally, the diversity of functions is the key to ensure its healthy operation. Based on the homogenization phenomenon of commercial complex development in some big cities in China in recent years, this study applies dissipative structure theory and synergistic effect theory to the study of functional diversity system of urban commercial complexes, and proposes a Shannon–Weiner biodiversity index model and calculation indexes based on the functional diversity measurement model. At the same time, correlation analysis and comparative analysis were conducted between the measurement results of spatial vitality and the calculation results of the diversity model to verify the scientificity and rationality of the proposed model. Finally, the SM City Plaza commercial complex in Xiamen was selected as a representative research object to measure the functional diversity of its weekdays and holidays and the coupling relationship between functional diversity and changes in spatial vitality. The calculation results show that although the comprehensive index of functional diversity of SM commercial complex is in a dynamic state of change, the overall level is high. The reasonable proportion of the six functional formats shows a high level of diversity, which effectively promotes the generation of commercial vitality and enhances the comprehensive benefits of the commercial complex; the change trends of functional diversity in time and space dimensions are in line with the actual situation, indicating that the proposed model has certain scientific and application values. On the basis of the completed empirical work, the scope of application and limitations of the calculation model and evaluation method, as well as the optimization of the index system are further pointed out.
Towards Multi-Scale Space-Time Characteristics of Air Quality and Population Exposure Risk
Authors: Xiao Xiao , Xie Xiao , Zhao Bingyu , Li Jingzhong , Xue Bing
Published: December 2021

In order to formulate policies to control regional air pollution and promote sustainable human–land system development, it is crucial to study the space–time distribution of air pollution and the population exposure risk. Existing studies are limited to individual fine particulate pollutants, which does not fully reflect the comprehensiveness of air quality. In addition, the spatiotemporal distribution of air quality and population exposure risk at different scales need to be further quantified. In this study, we used air monitoring station data and population spatial distribution data to analyze the spatiotemporal characteristics of air quality, including seasonal variations, variations before and during heating periods, and the occurrence frequency of priority pollutants in the traditional industrial areas of Northeast China in 2015. The population exposure–air pollution risk (PE-APR) model was used to calculate the population exposure risk at different spatial scales. The results suggest that GIS methods and air monitoring data help to establish a comprehensive air quality analysis framework, revealing spring–summer differentiation and the change trend of air quality with latitude. There are significant clustering features of air quality. A grid-scale population exposure–air pollution risk map is not restricted by administrative boundaries, which helps to discover high-risk areas of the main regional economic corridors and differences between inner cities and suburbs. This study provides a reference for understanding the space–time evolution of regional air pollution and formulating coordinated cross-regional air pollution strategies.
Formulation of Compressed Earth Blocks Stabilized by Glass Waste Activated with NaOH Solution
Authors: Larbi Sihem , Khaldi Abdelkrim , Maherzi Walid , Abriak Nor-Edine
Published: December 2021

Due to the increase in demand for building materials and their high prices in most developing countries, many researchers are trying to recycle waste for use as secondary raw materials. The aim of this study is the optimization of a mixture of compressed earth blocks based on two sediments. These sediments were tested through the Vicat test to determine the proportion of each one and the optimal water content. The mixtures were treated by adding 10% of blast furnace slag and different proportions of dissolved glass in a NaOH solution. The results indicated that the mixture of 70% Oran sediments with 30% Sidi Lakhdar sediments treated with 4% glass waste produced a CEB (compressed earth block) with high compressive strength with low porosity. In addition, formulated CEBs have a very good resistance to water immersion.
Intelligent Dendritic Neural Model for Classification Problems
Authors: Xu Weixiang , Jia Dongbao , Zhong Zhaoman , Li Cunhua , Xu Zhongxun
Published: December 2021

In recent years, the dendritic neural model has been widely employed in various fields because of its simple structure and inexpensive cost. Traditional numerical optimization is ineffective for the parameter optimization problem of the dendritic neural model; it is easy to fall into local in the optimization process, resulting in poor performance of the model. This paper proposes an intelligent dendritic neural model firstly, which uses the intelligent optimization algorithm to optimize the model instead of the traditional dendritic neural model with a backpropagation algorithm. The experiment compares the performance of ten representative intelligent optimization algorithms in six classification datasets. The optimal combination of user-defined parameters for the model evaluates by using Taguchi’s method, systemically. The results show that the performance of an intelligent dendritic neural model is significantly better than a traditional dendritic neural model. The intelligent dendritic neural model has small classification errors and high accuracy, which provides an effective approach for the application of dendritic neural model in engineering classification problems. In addition, among ten intelligent optimization algorithms, an evolutionary algorithm called biogeographic optimization algorithm has excellent performance, and can quickly obtain high-quality solutions and excellent convergence speed.
Is There Any Effect of Symmetry on Velocity of the Four Swimming Strokes?
Authors: Bartolomeu Raul , Rodrigues Pedro , Santos Catarina , Costa Mário , Barbosa Tiago
Published: December 2021

The different characteristics of the four swimming strokes affect the interplay between the four limbs, acting as a constraint to the force produced by each hand and foot. The purpose of this study was to analyze the symmetry of force production with a varying number of limbs in action and see its effect on velocity. Fifteen male swimmers performed four all-out bouts of 25-m swims in the four strokes in full-body stroke and segmental actions. A differential pressure system was used to measure the hands/feet propulsive force and a mechanical velocity meter was used to measure swimming velocity. Symmetry index was calculated based on the force values. All strokes and conditions presented contralateral limb asymmetries (ranging from 6.73% to 28% for the peak force and from 9.3% to 35.7% for the mean force). Backstroke was the most asymmetric stroke, followed-up by butterfly, front crawl, and breaststroke. Kicking conditions elicited the higher asymmetries compared with arm-pull conditions. No significant associations were found between asymmetries and velocity. The absence of such association suggests that, to a certain and unknown extent, swimming may benefit from contralateral limb asymmetry.
Acupuncture Effects on Cerebral Blood Flow during Normoxia and Normobaric Hypoxia: Results from a Prospective Crossover Pilot Study
Authors: Pecchio Oriana , Martinelli Massimo , Lupi Giuseppe , Giardini Guido , Caligiana Laura , Bonin Solange , Scalese Marco , Salvetti Ovidio , Moroni Davide , Bastiani Luca
Published: December 2021

Cerebral blood flow (CBF) is significantly influenced by exposure to hypoxia, both hypobaric and normobaric. Alterations in cerebral blood flow can play a crucial role in the pathogenesis of acute mountain sickness (AMS) and its symptoms, especially headache, dizziness, and nausea. Acupuncture has been proven to be effective in treating some cerebrovascular disorders and PC6 Nei Guan stimulation seems to enhance cerebral blood flow. Therefore, we have hypothesized that PC6 Nei Guan stimulation could affect CBF in acute hypoxia and could be used to contrast AMS symptoms. We evaluated blood flow in the middle cerebral artery (MCA) in normoxia, after 15 min in normobaric hypoxia (fraction of inspired oxygen (FiO2) 14%, corresponding to 3600 m a.s.l.) in basal conditions, and after PC6 Nei Guan stimulation, both by needle and by pressure. No comparisons with other acupuncture points and sham acupuncture were done. PC6 stimulation seemed to counteract the effects of acute normobaric hypoxia on end-diastolic velocity (EDV) in MCA, especially after acupuncture, and significantly reduced systolic and diastolic blood pressure. A rebalance of CBF could control some AMS symptoms, but further studies are necessary.
Comparison of Antigen Tests and qPCR in Rapid Diagnostics of Infections Caused by SARS-CoV-2 Virus
Authors: Klajmon Adrianna , Olechowska-Jarząb Aldona , Salamon Dominika , Sroka-Oleksiak Agnieszka , Brzychczy-Włoch Monika , Gosiewski Tomasz
Published: December 2021

Diagnostics of the coronavirus disease 2019 (COVID-19) using molecular techniques from the collected respiratory swab specimens requires well-equipped laboratory and qualified personnel, also it needs several hours of waiting for results and is expensive. Antigen tests appear to be faster and cheaper but their sensitivity and specificity are debatable. The aim of this study was to compare a selected antigen test with quantitative polymerase chain reaction (qPCR) tests results. Nasopharyngeal swabs were collected from 192 patients with COVID-19 symptoms. All samples were tested using Vitassay qPCR SARS-CoV-2 kit and the Humasis COVID-19 Ag Test (MedSun) antigen immunochromatographic test simultaneously. Ultimately, 189 samples were tested; 3 samples were excluded due to errors in taking swabs. The qPCR and antigen test results were as follows: 47 positive and 142 negative, and 45 positive and 144 negative, respectively. Calculated sensitivity of 91.5% and specificity of 98.6% for the antigen test shows differences which are not statistically significant in comparison to qPCR. Our study showed that effectiveness of the antigen tests in rapid laboratory diagnostics is high enough to be an alternative and support for nucleic acid amplification tests (NAAT) in the virus replication phase in the course of COVID-19.
How Does Severe Acute Respiratory Syndrome-Coronavirus-2 Affect the Brain and Its Implications for the Vaccines Currently in Use
Authors: Oldfield Philip R. , Hibberd Jennifer , Bridle Byram W.
Published: December 2021

This mini-review focuses on the mechanisms of how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) affects the brain, with an emphasis on the role of the spike protein in patients with neurological symptoms. Following infection, patients with a history of neurological complications may be at a higher risk of developing long-term neurological conditions associated with the α-synuclein prion, such as Parkinson’s disease and Lewy body dementia. Compelling evidence has been published to indicate that the spike protein, which is derived from SARS-CoV-2 and generated from the vaccines currently being employed, is not only able to cross the blood–brain barrier but may cause inflammation and/or blood clots in the brain. Consequently, should vaccine-induced expression of spike proteins not be limited to the site of injection and draining lymph nodes there is the potential of long-term implications following inoculation that may be identical to that of patients exhibiting neurological complications after being infected with SARS-CoV-2. However, further studies are needed before definitive conclusions can be made.