bluuebunny/crossref_metadata_2025 huggingface dataset:
Multilevel Thresholding of Color Image Segmentation Using Memory-based Grey Wolf Optimizer With Otsu Method, Kapur, and M.Masi Entropy
Authors: I Made Satria Bimantara  , Anny Yuniarti
Published: August 2023

Determining the optimal threshold value for image segmentation has become more attention in recent years because of its varied uses. Otsu-based thresholding methods, minimum cross entropy, and Kapur entropy are efficient for solving bi-level thresholding image segmentation problems (BL-ISP), but not with multi-level thresholding image segmentation problems (ML-ISP). The main problem is exponentially increasing computational complexity. This study uses the memory-based Gray Wolf Optimizer (mGWO) to determine the optimal threshold value for solving ML-ISP on RGB images. The mGWO method is a variant of the standard grey wolf optimizer (GWO) that utilizes the best track record of each individual grey wolf for the global exploration and local exploitation phases of the problem solution space. The solution candidates are represented by each grey wolf using the image intensity values and optimized according to mGWO characteristics. Three objective functions, namely the Otsu method, Kapur Entropy, and M.Masi Entropy are used to evaluate the solutions generated in the optimization process. The GridSearch method is used to determine the optimal parameter combination of each method based on 10 training images. Evaluation of the performance of the mGWO method was measured using several benchmark images and compared with five standard swarm intelligence (SI) methods as benchmarks. Analysis of the results was carried out qualitatively and quantitatively based on the average PSNR, RMSE, SSIM, UQI, fitness value, and CPU processing time from 30 tests. The results were analyzed further with the Wilcoxon signed-rank test. The experimental results show that the performance of the mGWO method outperforms the benchmark method in most experiments and metrics. The mGWO variant also proved to be superior to the standard GWO in resolving multi-level color image segmentation problems. The mGWO performance results are also compared with other state-of-the-art SI methods in solving ML-ISP on grayscale images and was able to outperform those methods in most experiments.
Enhancing Sales Forecasting Accuracy Through Optimized Holt-Winters Exponential Smoothing with Modified Improved Particle Swarm Optimization
Authors: I Putu Susila Handika  , I Kadek Susila Satwika
Published: August 2023

The Holt-Winters Exponential Smoothing method utilizes three smoothing parameters, namely alpha (α), beta (β), and gamma (γ), which have a significant impact on the accuracy of the forecasting process. One of the main challenges in the Holt-Winters Exponential Smoothing method is to find the best combination of the smoothing parameters, α, β, and γ, to achieve optimal forecasting accuracy. In this research, the MIPSO optimization method is used to find the optimal combination of values for α, β, and γ. The sales data used in the study covers the period from January 2021 to May 2023. The research results indicate the best accuracy achieved by combining the Holt-Winters Exponential Smoothing algorithm with the MIPSO optimization algorithm during the data period from January 2021 to May 2023, with a MAPE value of 9.1717%. Therefore, the use of the MIPSO algorithm helps discover the optimal combination of α, β, and γ parameters for forecasting.
Evaluation of the double mesh and intraperitoneal onlay mesh techniques in giant incisional hernias
Authors: Çiçek Okuyan Gülten , Talu Mehmet
Published: August 2023

Background: Giant incisional hernias are difficult to manage. The present study aims to comparatively evaluate the intraperitoneal onlay mesh (IPOM) technique to double-mesh repair techniques in patients with a midline abdominal wall incisional hernia larger than 15 cm (transvers width) that cannot be closed primarily.
 Material and methods: Patients who underwent repair surgery with the diagnosis of incisional hernia in our hospital between January 2017 and December 2019 were retrospectively evaluated. The repair was performed with open surgery using the IPOM technique in 19 patients and the double-mesh technique in 13 patients for 2 years to evaluate for postoperative complications, pain, and recurrence.
 Results: The mean age, gender distribution, body mass index, defect size, and American Society of Anesthesiologists scores were similar between the groups. The total rate of postoperative complications was 42.1% in Group A and 30.8% in Group B, with no significant difference between the groups (p > 0.05). Recurrence occurred in three patients (15.8%) in Group A, but it did not in Group B. Although the absence of recurrence in Group B was a remarkable finding, the difference was not statistically significant (p>0.05).
 Discussion: The IPOM and double-mesh techniques can be used safely to perform tension-free abdominal wall reconstruction in patients with complex and giant incisional hernias. However, the double-mesh technique may be preferred owing to its lower recurrence rate.
Giant prostatic enlargement: A presentation of a rare asymptomatic case
Authors: Kilibayev Baurzhan , Khairli Gafour , Zhanbyrbekuly Ulanbek , Abdugalimov Sherniyazdan , Keulimzhayev Nurbol , Sharapatov Yerzhan , Zhankina Rano
Published: August 2023

Benign prostatic hyperplasia is a histological diagnosis and the most frequent benign tumor in older men, and its incidence strongly correlates with advanced age. Giant prostate enlargement (GPE), also known as giant prostatic hyperplasia, is a term given for severely enlarged prostates that weigh more than 500g. GPE cases reported in literature is less than 30. We describe our experience of removing previously asymptomatic 528g prostate by open transvesical prostatectomy. According to transrectal ultrasound (TRUS) the prostate size is 482 ml and prostate‑specific antigen level of 5.1 ng/ml. Histological examination showed nodular prostatic hyperplasia, an adenomatous variant with foci of cystic atrophy, chronic prostatitis. The patient's post-operative recovery went without any relapses and complications.
The role of repeat computerized cranial tomography in pediatric blunt head trauma
Authors: Güler Sertaç , Üçöz Kocaşaban Dilber , Günaydın Yahya Kemal
Published: August 2023

Introduction: Computed cranial tomography (CCT) is commonly used in emergency departments (EDs) for pediatric blunt head injury (BHI) management. Cranial tomography is also repeated often unnecessarily due to physicians’ concerns about detecting the early onset of a possible new injury or progression of an existing one. This study aims to evaluate whether routine RCCT provides a significant change in patient management.

Material and methods: The study was performed as a 2-year retrospective analysis in the ED of a tertiary hospital. The medical records of pediatric BHI patients were reviewed, and the study included accessed data of 104 patients who underwent at least two CCT during their stay in the ED.

Results: The study included 104 out of 533 BHI patients. The mean age of these 104 patients was 6.2 years (median=4.5 years), and the majority were male (n=82, 78.9%). When the initial CCT results of the patients were analyzed, it was found that 51% (n=53) of the tomography results were normal. While there were substantial changes in 7 of the RCCTs, there were no significant changes in 97. Only 4 of these 7 patients who had significant changes were taken to the emergent operating room. None of these patients belonged to the group of patients whose CCT was classified as "normal" on admission (p<0.05).

Conclusion: According to our results, routine RCCT for BHI in pediatric patients did not result in a significant change in patient management.
No-reflow phenomenon and triglyceride-glucose index in acute myocardial infarction
Authors: Kerkutluoglu Murat , Celik Enes , Dagli Musa , Gunes Hakan
Published: August 2023

Objective: The objective of this research was to evaluate the association between the measured triglyceride/glucose index (TyG) and the occurrence of no-reflow phenomena in patients with acute ST-elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI).

Material and methods: This study comprised 242 patients who were treated with primary PCI for acute STEMI. The values of triglycerides and glucose at the time of admission were derived from the patient's file. Using coronary angiography records, the grade of post-procedural thrombolysis in myocardial infarction (TIMI) flow was determined.

Results: After PCI, patients were divided into two groups based on their TIMI flow grade: the normal coronary flow group (n=202) and the reduced coronary flow (no-reflow) group (n=40). The group with no-reflow had a poorer left ventricular ejection fraction and a higher prevalence of diabetes compared to the group with normal coronary flow. Individuals with a lower grade of TIMI flow had a substantially higher TyG index (9.7±0.25 vs. 8.8±0.5, p=0.001). The receiver operating characteristic (ROC) curve revealed that the optimal cut-off point of the TyG index for predicting no-reflow was >9.2 with specificity of 72.8% and sensitivity of 97.5% (area under the curve = 0.884; 95% confidence interval, 0.837-0.921; p=0.001).

Conclusion: At admission, patients with STEMI who experienced no reflow after primary PCI had a higher TyG index. In such cases, the TyG index can be utilized as a predictor of no-reflow.
Pembuatan Purwarupa Alat Ukur Konsentrasi CO2 Berbasis NodeMCU ESP8266
Authors: Yudita Fitria , Syafitri Nia , Wahyuni Dwiria
Published: August 2023

Carbon dioxide (CO2) is the largest contributor to greenhouse gas emissions, resulting in an increase in global temperatures. Unfortunately, this knowledge is not yet widely known among the general public. Therefore, providing information on daily CO2 levels can serve as a means to educate and raise awareness about the dangers associated with CO2 levels. To simplify access to CO2 concentration information, a prototype of a CO2 concentration measurement device based on the NodeMCU ESP8266 microcontroller, which can be connected to Wi-Fi, has been developed. To ensure data accuracy, the CO2 measurement device was calibrated using the NodeMCU ESP8266 microcontroller and data from an outdoor CO2 monitoring instrument at the BRIN (BPAA Pontianak) office, with an error value of 4.08%. The collected data from this device can be accessed through the Blynk application or a Google Sheets link. The test results demonstrate that the device can provide CO2 concentration levels with higher readings in areas characterized by high vehicle traffic, smoking, combustion activities, or a crowd of people.
Studi Difusi Gadolinium Makrosiklik Pada Sel Kupffer Menggunakan Simulasi Monte Carlo Cell
Authors: Gillian Alehandra Gore Stcay , Sutresno Adita , Setiawan Andreas
Published: August 2023

Contrast agents containing gadolinium (Gd) are classified into two types based on their molecular structure: linear and macrocyclic. The macrocyclic type is known for its enhanced stability, resulting in minimal release of Gd ions within the body. The distribution of macrocyclic Gd within the kupffer cells in the liver, undergoes a diffusion process. In this study aimed to investigate the diffusion mechanism of macrocyclic gadolinium in kupffer cells. It employs a simulation geometry model employing Monte Carlo Cell and a three-compartment experimental model. The kupffer cell model in the simulation was generated using Blender 2.93 application, consisting of three compartments, while the experimental model involved three compartments containing a NaCl solution. The simulation results revealed that kupffer cell membran densities of 1480 molekul/μm2, 2961 molekul/μm2, 4442 molekul/μm2, and 5922 molekul/μm2 exhibited respective half-lifes of 0.547 s, 0.261 s, 0.198 s, and 0.148 s. Furthermore, the experimental results indicated that the models with 100, 200, 300, and 400 holes displayed half-lives of 1720 s, 578 s, 530 s, and 240 s, respectively. Result this research shows that higher membrane density and more significant number of holes results in faster molecule diffusion.
Pengolahan Air Sadah Menggunakan Zeolit Buatan Dari Batu Apung Lampung Dan Daun Kerai Payung
Authors: Agustin Nindia , Karo Karo Pulung , Sudibyo Sudibyo , Suprihatin Suprihatin
Published: August 2023

This research was conducted to determine the composition and crystal structure of the artificial zeolite produced, as well as the ability of artificial zeolite to reduce calcium and magnesium content in hard water. The zeolite was prepared using the hydrothermal method by mixing sodium silicate from Lampung pumice silica, sodium aluminate from aluminum can waste and charcoal from sunshade umbrellas. The artificial zeolite products were characterized using XRF, XRD, UV-Vis spectrophotometric and ICP-EOS. The results showed that the composition of the artificial zeolite was aluminum, silica, phosphorus, potassium, calcium, titanium, vanadium, chromium, manganum and ferum. The crystal structure of the optimum sample from the UV-Vis spectrophotometric characterization obtained the crystal structure of a natural zeolite type, namely Chabazite. And the artificial zeolite which was tested for adsorption on hard water could reduce the calcium content by 36.57% but could not reduce the magnesium content.
Analisis Grafik Karakteristik Sensitivitas Sensor MQ-135 untuk Menentukan Persamaan Hubungan antara ppm dan Rs/Ro
Authors: Bangkit Sanjaya Umbu Ari
Published: August 2023

MQ-135 sensor is a sensor capable of detecting acetone, toluene, alcohol, carbon dioxide, ammonia, and carbon monoxide. This sensor has been widely used as the main component in gas-based research. Analysis of sensor sensitivity characteristics is the first step for researchers to do to obtain an equation for the relationship between ppm and Rs/Ro. However, in most studies only analyzing gas charts are the object of research. This causes other researchers to do their own analyses for different types of gas. Based on that problem, the authors performed a graphical analysis of the sensitivity characteristics of the MQ-135 sensor for acetone, toluene, alcohol, carbon dioxide, ammonia, and carbon monoxide gases. The coordinate points for these gases are obtained using the WebPlotDigitizer application and coordinate data were analyzed using power regression. Based on the analysis results, the relationship equation between ppm and Rs/Ro for acetone, toluene, alcohol, carbon dioxide, ammonia, and carbon monoxide gas is shown in equations 16, 17, 18, 19, 20, and 21 respectively.
Semiotic Analysis of Richard Ross’ Art Photography Juvenile-in-Justice
Authors: Bolkiah Muhammad Faiz , Rahmadi Rahmadi
Published: August 2023

In art photography, there is an idea that artists want to convey to the public. Because photography records reality, to convey a specific idea it is often necessary to use symbols from real objects that are appropriate so that the viewer can direct his mind to where the artist wants. It is hoped that this research will explain why Richard Ross' work has succeeded in bringing the public in the direction that the artist wants by using the right visual symbols. Then from the method that has been read, novice photography artists can follow the method they use so that the work can become more visually precise.
A Systemic Functional Linguistic Study on Language Use of Indonesian Students in Writing
Authors: Alwasilah Yuzaki Adam , Gunawan Wawan
Published: August 2023

Language is a form of cultural wealth of a nation. Analysis of the use of a language is an interesting topic to study. The current manuscript implement Systemic functional linguistics (SFL) theory which focuses on exploring the social and cultural context of language use in a piece of writing. SFL it self is an approach to linguistics that considers language as a social semiotic system which focuses on the function of language in social contexts and the choices that language users make. This paper is intended to analyze students’ recount text writing in SFL perspectives, and how teachers can assist students in solving writing problems. Specifically this study hopefully can identify in what aspects that Indonesian students usually made some errors, based on three metafunctions from SFL perspective. The finding shows that most of the students did errors in the use of tense, generic structure, and grammatical errors. Thus, Transition-Action-Details (TAD) could be used as one of the strategies in teaching writing, especially writing recount text in Indonesian context.
Logico-Semantic Relation in The World Health Organization’s Covid-19 Myth-Busters
Authors: Juliansyah Edfan , Indrayani Lia Maulia , Krisnawati Ekaning
Published: August 2023

In delivering the contents of the World Health Organization’s Covid-19 Myth-busters, the creator realized clause complexes besides clause simplexes. This research focuses on analyzing logico-semantic relation of clause complex. Thus, it can reveal the creator’s intention in realizing the clause complexes when conveying the myth-busters to the people of the world. This research utilizes a qualitative-descriptive research method. There are 48 expansion relationships in the myth-busters. They include one elaboration relationship, 22 extension relationships, and 25 enhancement relationships. Enhancement is the most-realized clause relationship in the myth-busters. This means that the creator intended to convey complementary ideas in the clause complexes by referencing time, condition, reason, purpose, and cause related to managing misinformation about Covid-19.
Mastery Learning Model based on Appreciation Approach at Photography and Film Program, Universitas Pasundan, Bandung
Authors: Reinaldi Harry
Published: August 2023

The course’s subjects must contain appreciation dan encourage creativity process from the beginning, because within them exist the value of pedagogic, aesthetic, ethic, sociology, philosophy, morality, even religious. There are problems in learning process of Photography 1 Course, at Fotografi and Film Programme, Faculty of Art and Literature, Pasundan University, Bandung. The problems consists of several factor, such as (1) planning, (2) actualization, (3) learning process, and (4) the obstacles and the supports. This scientific research is held in order to identify the cause of the problems, then to analyze them. The purposes are to (1) developing curriculum, (2) upgrading quality of teacher, and (3) upgrading quality of the learning process in the class itself. This case study research’s design had been chosen to: (1) find the facts about obstacles and the supports of the learning process at Photography 1 Course, from the step of planning until the step of actuating, (2) understanding the problems occurred in teacher’s and student’s side, (3) formulating the conclusion and suggestion for upgrading the quality of the learning process. Data collecting technique was done by (1) study of previous documents, (2) direct observation, (3) interview, and (4) study of the current documents. The data was analyzing by matching, filtering, processing, dan verification. The results of this research are (1) to find some factors which had been became a barrier in order to runs the learning process in Photography 1 course, (2) to find a way and solution to overcome the barrier, and to fulfill the shortcoming, (3) to fix the whole learning process, which include curriculum, learning matters, learning process itself, teacher’s competency, students’ creativity, and also facilities and infrastructure. The result of this research gives suggestion about fixing connected important things between: (1) curriculum, (2) learning process, (3) teacher, (4) students, and of course to encourage preceding research.
Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms
Authors: Skelly Andrea C. , Chang Eric , Bordley Jessica , Brodt Erika D. , Selph Shelley , Fu Rongwei , Holmes Rebecca , Dana Tracy , Stabler-Morris Shay , Riopelle Dakota , Chou Roger
Published: August 2023

Objectives. To evaluate the comparative effectiveness and harms of external beam radiation therapy (EBRT) for palliative treatment of metastatic bone disease (MBD). Data sources. Four electronic databases from 1985 to January 30, 2023; a targeted search for re-irradiation through January 30, 2023; reference lists; and a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) and nonrandomized studies of interventions (NRSIs) comparing dose-fractionation schemes and EBRT delivery techniques (for initial radiation and re-irradiation, i.e., retreatment for recurrent or persistent pain) and EBRT alone versus in combination with other palliative treatments. Study risk of bias was assessed using predefined criteria. Strength of evidence (SOE) was assessed for the primary outcomes of pain, function, spinal cord compression relief, quality of life, and harms. Results. We included 53 RCTs and 31 NRSIs; most were fair quality. In patients receiving initial radiation for MBD there was a small increase in the likelihood of overall pain response (improved pain measures with stable or decreased analgesic use) for multiple fraction (MF) EBRT versus single fraction (SF) EBRT up to 4 weeks post-radiation therapy (SOE: moderate) and for higher dose (6 or 8 Gy) SF EBRT versus lower dose (4 Gy) SF EBRT up to 52 weeks post-radiation therapy (SOE: low). SF and MF EBRT did not differ at later followup (SOE: moderate) nor did comparisons of MF EBRT dose/fractions (SOE: moderate ≤12 weeks; low >12 weeks). Re-irradiation was more common with SF versus MF EBRT. Stereotactic body radiation therapy (SBRT) (SF or MF) was associated with a slightly higher (up to 20 weeks, SOE: low) and moderately higher (30 weeks; SOE: moderate) likelihood of overall pain response versus MF EBRT. For re-irradiation, SF and MF SBRT had a similar likelihood of overall pain response, as did SF versus MF EBRT (SOE: low for all). Harms may be similar across dose/fraction schemes and techniques; serious harms were rare. Comparative effectiveness evidence for EBRT was sparse. Conclusions. In patients with uncomplicated MBD receiving initial palliative radiotherapy, the likelihood of overall pain response for SF and MF EBRT is probably similar, particularly after 4 weeks; re-irradiation was more common with SF-EBRT. SF and MF SBRT may provide slightly greater likelihood of overall pain response versus MF EBRT; evidence is limited. SF and MF EBRT may have similar likelihoods of overall pain response in patients receiving re-irradiation. High-quality evidence comparing SBRT with EBRT is needed in populations with complicated and uncomplicated MBD, as is research on effectiveness of EBRT versus other treatments. Update: An addendum is located at the end of the main report, before the appendixes.
DO THEY COMMIT PERJURY?: A STUDY OF REPEATING NARRATIVE OF A CRIME SCENE IN PETER DEXTER’S PARIS TROUT
Authors: Wu Sufen
Published: August 2023

In Paris Trout, a novel based on actual cases, American writer Pete Dexter arranges a crime scene to be told eight times from different perspectives. A close look at repeating narratives leads to discovering certain discrepancies between the narrator’s account and the characters, especially the criminals’. Dexter renders the criminals’ statements questionable by giving the omniscient heterodiegetic narrator authority and letting his account exert the primary effect. Based on the related laws, this essay finds out that the criminals commit perjury in their statements to exonerate themselves. Moreover, Dexter reveals that their illicit doings are under the defense lawyer’s instructions. By doing so, Dexter puts lawyers’ professional ethics at the center of the story. Showing the truth or winning the lawsuit for the customer? This question is an ethical issue that every lawyer ponders. In order to vigorously promote this kind of thinking, the novelist purposely forms a huge difference in characterization. The defense lawyer is modeled on a lawyer of integrity and honesty who is committed to revealing the truth. Through the ironic change in characterization, Dexter criticizes defense lawyers who don’t have professional ethics, a situation rampant in American society in the 1980s.
The role of Islamic crowdfunding and the mediating effect of technology adoption on SMEs’ sustainability
Authors:   Faculty of Business and Management, Universiti Teknologi MARA Puncak Alam, Abd Rashid Norasekin , Mamat Norzawani ,   Faculty of Business and Management, Universiti Teknologi MARA Puncak Alam, Hasim Norhasdalina ,   Faculty of Business and Accountancy, Universiti Selangor, Zainal Abidin Maziana ,   Faculty of Business and Accountancy, Universiti Selangor
Published: August 2023

Due to the excessively strict procedures enforced by financial institutions and government authorities, MSMEs in Malaysia are struggling to sustain especially during Covid 19 pandemic. To address this critical issue, with the advance in technology, entrepreneurs have become more independent and creative in raising capital through a process known as crowdfunding. This study intends to examine the relationship between Islamic crowdfunding, financial literacy, and technology adoption toward MSME’s sustainability during Covid 19 pandemic. Based on the random sample of 259 MSMEs, we assessed the correlation between all the variables using SmartPLS 3.3. The result showed that Islamic crowdfunding, financial literacy, and technology adoption affects positively on MSMEs’ sustainability. The results also indicate that financial literacy was the most influencing factor towards MSMEs’ sustainability during the Covid 19 pandemic situation.
New species of Travisia Johnston, 1840 (Annelida, Travisiidae Hartmann-Schröder, 1971) from south-eastern Australia
Authors: Avery Lynda , Vodopyanov Stephan , Wilson Robin S.
Published: August 2023

Avery L., Vodopyanov S. & Wilson R.S. 2023. New species of Travisia Johnston, 1840 (Annelida, Travisiidae Hartmann-Schröder, 1971) from south-eastern Australia. Memoirs of Museum Victoria 82: 133–142. Two new species of Travisia Johnston, 1840 (Annelida, Travisiidae) are described from the continental shelf of south-eastern Australia: Travisia tribus sp. nov. and Travisia una sp. nov. Travisia olens novaezealandiae Benham, 1927 is raised to species rank as Travisia novaezealandiae Benham, 1927 new status. We describe epidermal structures using scanning electron microscopy, and discuss pygidial morphology of the two new Travisia species and distinguish an additional character. We recognise four species of Travisia recorded from Australia and include a dichotomous key to allow their identification. A separate downloadable resource provides access to an annotated morphological character list for Travisia species, a downloadable interactive key using the Delta (Descriptive Language for Taxonomy) Intkey software, and concise descriptions and minimal diagnoses and descriptions of all currently recognised species of Travisia.
Pengaruh Kinerja Keuangan Terhadap Financial Distress pada Perusahaan Sektor Energi
Authors: Revanza Mochamad Derry , Wahyuni Nanik
Published: August 2023

Tujuan dari penelitian ini adalah untuk memberikan bukti antara kinerja keuangan yang buruk dengan kesulitan keuangan. Penelitian sebelumnya telah mengaitkan tekanan finansial dengan kinerja yang lebih buruk, sedangkan penelitian lain menunjukkan sebaliknya. Studi ini dilakukan di Indonesia dengan menggunakan data yang dikumpulkan dari cross-section perusahaan energi yang diperdagangkan di BEI. Purposive sampling digunakan untuk memilih 9 bisnis untuk penelitian ini dari total 76 di industri energi. Temuan menunjukkan bahwa kesulitan keuangan dipengaruhi oleh rasio utang terhadap aset dan rasio utang terhadap ekuitas, tetapi tidak dipengaruhi oleh rasio lancar, marjin laba bersih, atau marjin laba kotor.
Keterkaitan Sustainability Report, Kesetaraan Gender, Earning Per Share terhadap Harga Saham Perdana
Authors: Akadiati Victoria Ari Palma
Published: August 2023

Tujuan dari penelitian ini adalah menganalisis secara empiris pengaruh sustainability report, kesetaraan gender, dan earning per share terhadap harga saham perdana pada perusahaan initial public offering tahun 2022. Penelitian bersifat kuantitatif dengan metode penelitian menggunakan teknik purposive sampling dengan analisis data resgresi linier berganda. Hasil penelitian menunjukkan bahwa sustainability report tidak memiliki pengaruh terhadap harga saham perdana. Kesetaraan gender dan earning per share memiliki pengaruh signifikan terhadap harga saham perdana. Pentingnya harga saham dalam sebuah perusahaan dapat digunakan sebagai alat ukur kinerja perusahaan dalam memprediksi adanya return dan mitigasi risk dimasa yang berkelanjutan. Implikasi hasil penelitian ini dapat digunakan sebagai literasi penelitian berikutnya dan sebagai bahan pertimbangan bagi pihak berkepentingan dalam mengambil keputusan berinvestasi saham di pasar bursa efek Indonesia.
PERSEPSI WISATAWAN NUSANTARA TERHADAP DAYA TARIK WISATA EMBUNG KLEDUNG, TEMANGGUNG
Authors: Carrillo Atanasius , Indrawati Yayu , Oka Karini Ni Made
Published: August 2023

The purpose of this research is to find out the perceptions of domestic tourists towards 4A (attraction, amenity, accessibility, ancillary) at Embung Kledung. This research is located in Embung Kledung, precisely on Jalan Raya Parakan - Wonosobo No. km. 12, Rice Field Area, Kledung, Kledung District, Temanggung Regency, Central Java, 56264. Data collection techniques used in this study included observation, distribution of questionnaires, interviews, literature study and documentation. The sampling technique in this study was purposive sampling by distributing questionnaires to domestic tourists who had visited the Embung Kledung tourist attraction. The number of respondents in this study were 100 people/respondents. The data analysis technique used in this study is a mixed methods analysis technique consisting of quantitative descriptive analysis and qualitative descriptive analysis. The results obtained from this study are the perceptions of domestic tourists towards attractions that have an average score of 3.35 and are in the very agree category. Domestic tourists' perception of amenities has an average score of 2.764 and is in the agree category. Domestic tourists' perception of accessibility has an average score of 2.543 and is in the agree category. Domestic tourists' perception of ancillary service has an average score of 2.746 and is in the agree category. However, there are several indicators that are in the category of strongly disagreeing, such as the variety of accommodations provided and the condition of the road leading to the Embung Kledung tourist attraction.
TANTANGAN DAN HAMBATAN PENGUSAHA AKOMODASI LOKAL DALAM MENGELOLA ONLINE TRAVEL AGENT DI NUSA PENIDA
Authors: Darsana I Wayan
Published: August 2023

The purpose of this study to find out marketing with online travel agents used by local accommodation entrepreneurs on Nusa Penida Island and how local entrepreneurs manage these OTAs to increase the existence of their accommodation businesses. Entrepreneurs did not understand how to manage online travel agent, such as a lack of concern for maintaining the system and price disparity rates and the lack of ability to carry out innovative promotions through OTA, as well as dependence on offline travel agents. The theory of marketing and OTA have used in this researched, data obtained through interviews and analyzed using qualitative descriptive methods. Research results show thatLocal accommodation entrepreneurs need to increase their network or partners in promoting the accommodation business by registering their property business with online travel agents other than Booking.com and Agoda and actively managing accommodation marketing in maintaining their accommodation business.
STRATEGI PEMASARAN KERAJINAN TENUN IKAT SUMBA SEBAGAI PRODUK INDUSTRI KREATIF PENDUKUNG PARIWISATA DI SUMBA TIMUR
Authors: Hanja Hendrina Mbitu , Sasrawan Mananda I GPB. , Eka Mahadewi Ni Putu
Published: August 2023

This research refers to Sumba ikat weaving crafts as a creative industry product in East Sumba, a case study at one of the souvenir shops namely Artshop Maradda Indah. This study aims to find out the strategy of Artshop Maradda Indah in marketing Sumba ikat weaving crafts as a creative industry product in East Sumba and look for new strategies based on existing strengths, weaknesses, opportunities, and threats. The sample determination technique uses accidental sampling technique by distributing internal environment questionnaires to 130 customers at Artshop Maradda Indah. Respondents to answer external indicators were determined by the quota sampling technique, namely as many as 10 respondents using the likert scale technique. Data analysis techniques using IFAS & EFAS analysis methods, IE matrix analysis and SWOT analysis. The results based on the dissemination of the internal questionnaire, 8 strengths and 4 weaknesses were obtained with an IFAS score of 2.87 and 9 opportunities and 5 threats with an EFAS score of 2.85 from the distribution of the external environment questionnaire. Thus, it can be known that Artshop Maradda Indah is in cell V on the IE matrix with a strategy that can be applied of is a growth and stability strategy.
BAURAN PROMOSI DAYA TARIK WISATA CURUG SEWU, KENDAL
Authors: Priyanto Muhammad Irfan , Suwena I Ketut , Eka Mahadewi Ni Putu
Published: August 2023

Curug Sewu waterfall is the highest waterfall in Central Java province, Curug Sewu waterfall is a leading tourist attraction owned by Kendal Regency, besides having natural beauty and very cool air, Curug Sewu waterfall has artificial infrastructure such as a zoo, pond swimming pools, and children's playgrounds, so that the Curug Sewu waterfall has enormous tourism potential, in addition to having tourism potential, tourist attractions must have the right tourism strategy to attract tourists to visit, referring to this, researchers are interested in researching about " Promotion Mix of Curug Sewu Tourism Attraction, Kendal Regency (Case Study of Kendal Regency Disporapar Work Program)”. Data collection techniques in this study include observation, in-depth interviews, documentation, literature study and questionnaires. The technique of determining informants in this study uses purposive sampling which is a technique of determining informants and sources with certain objectives in accordance with the research theme. The results obtained in this study are Curug Sewu has enormous tourism potential and can be further developed, the promotional mix carried out by the Kendal Regency Disporapar is very good, with the mess selling indicator value getting the best results from the four promotional mix indicators that have been carried out by the Kendal Regency Disporapar.
FAKTOR YANG MEMPENGARUHI KEPUASAN WISATAWAN MANCANEGARA MENGGUNAKAN KAPAL PESIAR PINISI PRANA DI LABUAN BAJO
Authors: Hidayatullah Syarif , Kusuma Negara I Made , Dewi LGLK.
Published: August 2023

As one of the National Tourism Strategic Areas, Labuan Bajo is starting to be visited by many tourists. Many pinisi ships operate in Labuan Bajo. One of them is Prana. Due to the high price offered, the Prana manager must give satisfaction to tourists. This journal aims to determine the characteristics of tourists and the factors that influence the satisfaction of tourists who use the pinisi Prana cruise ship in Labuan Bajo. The sample choosen with a purposive sampling technique with a number of respondents 100 foreign tourists. Data analysis techniques: validity test, reliability test, and factor analysis. The results indicate that: the characteristics of tourists who use the pinisi Prana cruise ship in Labuan Bajo are 25 - 50 years old, male, work as an entrepreneur, latest undergraduate education, not married, for recreation, stay for 5-7 days, get information from friends / relatives, going on trips with friends, and planning trips by yourself. From 2 initial factors consisting of 22 indicators, 6 factors are formed that affect the satisfaction of tourists who use the pinisi Prana cruise ship. The 6 factors are service quality (29,20%), security (8,61%), price & image (7,81%), convenience (6,11%), facilities (5,33%), and trust (5,07%). The dominant factor affecting the satisfaction of tourists using the Pinisi Prana cruise ship in Labuan Bajo is the quality of service with an eigenvalue of 6,42 and a percentage of variance of 29,20%.
PENGARUH BAURAN PEMASARAN TERHADAP KEPUTUSAN PEMBELIAN PRODUK WISATA DI BLIBLI TRAVEL PADA MASA PANDEMI COVID-19
Authors: . Viona , Eka Mahadewi Ni Putu , Agus Wikanatha Sagita Putu
Published: August 2023

This research is conducted because the marketing mix strategy applied by Blibli Travel was ineffective. This study aims to determine the effect of the 7P marketing mix (product, price, place, promotion, people, process, and physical evidence) and which marketing mix had the most significant influence on tourism products purchasing decisions at Blibli Travel during the Covid-19 pandemic. This sample is determined by purposive sampling method with total sample of 125 respondents. Data collection uses questionnaires distributed online through social media, interviews with Blibli Travel management and several Blibli Travel consumers, observations, literature studies, and documentation. The data analysis technique is descriptive quantitative with validity test, reliability test, classical assumption test, multiple linear regression analysis, t test, F test, and coefficient of determination test. This study uses the IBM SPSS Statistics 25 for MacOS program. The results indicate that product and physical evidence partially have a significant effect on tourism products purchase decision at Blibli Travel while price, place, promotion, people, and process partially have no significant effect on tourism products purchase decision at Blibli Travel. Meanwhile, simultaneously, the marketing mix has a significant effect on tourism products purchase decision at Blibli Travel with a coefficient of determination of 69%.
Oleuropein attenuates placental growth factor expression by regulating oxidative stress and apoptosis in acrylamide hepatotoxicity
Authors: TATAR Musa , TÜFEKCİ Kiymet Kubra
Published: August 2023

The liver is susceptible to toxic effects, as it is the main site of acrylamide biotransformation and detoxification. Researchers have claimed that placental growth factor (PlGF) and its pathway are potentially involved in numerous diseases, including liver fibrosis and angiogenesis. Oleuropein is a natural phenolic compound with potent antioxidant effects. The purpose of this study was to examine the role of PlGF and the potential protection provided by oleuropein in acrylamide hepatotoxicity. Wistar albino rats were assigned into control, acrylamide (ACR) (5 mg/kg), oleuropein (OLE) (4.2 mg/kg), and ACR+OLE groups. Acrylamide and oleuropein were administered for 21 days. The control group received only physiological saline. Liver tissues were evaluated histologically and immunohistochemically. Histological examinations revealed significant enlargement of the sinusoidal vessels and abundant hepatocytes with pyknotic nuclei in the ACR group. Acrylamide toxicity resulted in elevated PlGF, accumulation of 8-hydroxydeoxyguanosine (8-OHdG), and increased Caspase-3 immunoreactivity in the liver. Oleuropein treatment reduced the increased expression of PlGF, 8-OHdG, and Caspase-3 against these deleterious effects observed in the ACR group. A positive correlation was observed between PlGF levels as well as oxidative stress and apoptosis markers in acrylamide toxicity. Oleuropein probably counteracted this mechanism by exhibiting antioxidant activity.
Detection of Methicillin-resistant Staphylococcus aureus (MRSA) resistant to vancomycin and linezolid in bulk tank milk by E-test method
Authors: ONARAN ACAR Bahar , KEYVAN Erhan
Published: August 2023

Staphylococcus aureus is considered a serious threat to public health, besides is one of the most common causes of subclinical mastitis in dairy cows. Therefore, especially methicillin-resistant Staphylococcus aureus (MRSA) is among the most critical reasons for antibiotic treatment. Monitoring the antibiotic resistance of MRSA from livestock animals and foods is of great significance. The E-test method is a suitable option for detecting antibiotics' minimum inhibition concentration (MIC) value because it is an easy and fast assay to perform. This study aimed to detect vancomycin, teicoplanin, and linezolid resistance of milk-borne 34 MRSA isolates with subclinical mastitis by the E-test method to determine MIC values. The study determined that 8.8% of MRSA isolates isolated from milk with subclinical mastitis were also resistant to vancomycin and 11.7% to linezolid, while none of the isolates were determined to be resistant to teicoplanin, according to EUCAST. The data obtained from the study reveal that the efficacy of vancomycin and linezolid antibiotics, which are commonly used against MRSA infections, are in danger. Especially before MRSA treatment, MIC values of antibiotics should be determined, and appropriate antibiotics should be used in effective doses.
Decreased gene expression of RIPK1 and RIPK3, necroptosis players, in calves with sepsis
Authors: DOGAN Atilla , BAYKAN Yakuphan , AKÇORA YILDIZ Dilara
Published: August 2023

Background With the increase in the world population, the need for livestock-based nutrition is also increasing. In addition, the livestock sector becomes more important as it contributes to the economy However, sepsis has high morbidity and mortality rate in newborn calves and can cause severe economic losses. Therefore, new biomarkers to distinguish sepsis from other diseases are urgently needed in veterinary medicine. In the present study, we investigated for the first time the gene expression levels of necroptosis members, including RIPK1 and RIPK3, and one of the NF-kB activators RIPK2, in calves with sepsis.

Methods and results We examined the mRNA levels of RIPK1, RIPK3, and RIPK2 using qPCR in 10 healthy Holstein calves and 20 Holstein calves with sepsis due to suffering from enteritis infection between 1-20 days of age. The hematologic parameters, including leukocytes, erythrocytes, hemoglobin, hematocrit, and platelets, were evaluated in the calves included in this study. The results showed that calves with sepsis had prominently lower mRNA levels of RIPK1 and RIPK3 than those in healthy calves. Besides, RIPK2 mRNA expression was absent in healthy calves and calves with sepsis.

Conclusions In veterinary medicine decreased RIPK1 and RIPK3 mRNA levels might be biomarkers to diagnose sepsis in calves.
Transcriptomic Analysis of CBD-Exposed Rat Placentae Reveals Down-Regulated Angiogenic Pathways and Up-Regulated Metabolic Processes
Authors: Ejeckam Alexis O. , Natale Bryony V. , Allen Sofia , Lee Kendrick , Hardy Daniel B. , Natale David R.C.
Published: August 2023

Following nicotine, cannabis is the most used drug during pregnancy. In utero cannabis exposure is linked to adverse outcomes, including fetal growth restriction. Cannabidiol (CBD), the non-hallucinogenic constituent of cannabis, is perceived as safe for use during pregnancy by ~25% of women. While studies assessing the effects of Δ-9-THC, the other principal cannabinoid in cannabis, have been initiated, research examining the impact of CBD on pregnancy is scarce. The placenta facilitates the exchange of gas, nutrients and waste between the fetus and mother. Our group has recently identified altered placental morphology and reduced fetal growth after in utero CBD exposure in rats. However, the influence of CBD on genes, transcription factors and biological processes in the placenta has not been assessed. This study aimed to identify biological pathways in the placenta that were significantly altered by CBD-exposure and correlate the findings with previously performed histological analysis. Pregnant rats were administered a daily dose of 3 mg/kg CBD or a vehicle control from embryonic day (E) 6.5-18.5. On E19.5, placentae were harvested for transcriptomic analysis. RNA extraction, library construction and bulk RNA sequencing was performed by Genome Quebec. The top differentially expressed genes were analysed using Metascape software, revealing the most up- and down-regulated Gene Ontology (GO) biological process pathways. Down-regulated GO biological processes included tube morphogenesis, angiogenesis, and blood vessel morphogenesis, which supported the angiogenic complications identified by histology. Further, the most significantly up-regulated GO biological processes were metabolic, including peptide, glycoprotein, glycosaminoglycan, and tetrahydrofolate. This is significant, as the histological analysis identified elevated Glut3 expression in the placentae from CBD-exposed pregnancies. Elevated Glut3 in fetal growth restriction is associated with changes to metabolic pathways. Consequently, additional studies will include analysis of CBD-exposed rat trophoblast cells to establish whether metabolic changes may underlie the altered morphology identified in CBD-exposed placentae.
Theatrical Complications
Authors: Ma Benjamin
Published: August 2023

Though theatricality as a concept has been extensively and variously theorized vis-a-vis live theatre through the sharing of space (see Cole 1975; Davis and Postlewait 2003; Davis and Postlewait 2003; Petrović-Lotina 2019; Shank 1969), through the rejection of the quotidian (Durang 1999; Heim 2020; White 2019), and through heightened expression (Carlson 1990; Peterson 2023; Smith 1984); many of its core tenets have recently been challenged through the rising prominence of virtual theatre. In this paper, I explore various theories of and about theatre to redefine “theatricality” as a term in its application to virtual (music) theatre. Additionally, I investigate how Rise, Shine, Sing!, a weekly, online participatory community music theatre project, reconfigures the demands for its participants to assume the unique role of spectator-performer, thus redefining the terms of engaging with and through theatricality in this medium.

My interest in redefining theatricality in virtual contexts is motivated by the (post) pandemic impulse to prioritize audience safety in line with public health measures to protect those who are at risk, whether for reasons of age, ability, or health status. Because virtual theatre is therefore now a matter of access, theatricality is in a position to be (re)defined. I explore this in three ways: through further theorizing around the suspension of disbelief–a departure from the quotidian space that defines our daily living–which characterizes theatricality (see Causey 2006; Féral 2002; MacDonald 2013); through theatre’s reconfiguration of the social world’s constructivity to develop new iconography in gesture; and through a renegotiation of the opportunities for heightened experience on the part of the performer-spectator.