bluuebunny/crossref_metadata_2025 huggingface dataset:
The Transcription Factor DAF-16 is Essential for Increased Longevity in C. elegans Exposed to Bifidobacterium longum BB68
Authors: Zhao Liang , Zhao Yang , Liu Ruihai , Zheng Xiaonan , Zhang Min , Guo Huiyuan , Zhang Hao , Ren Fazheng
Published: August 2017

The longevity-promoting benefits of lactobacilli were hypothesized as early as 1907. Although the anti-aging effects of lactic acid bacteria (LAB) have been observed in nematodes, rodents and humans for over a century, the mechanisms underlying the effects of probiotics on aging have rarely been assessed. Using the Caenorhabditis elegans (C. elegans) model, various studies have elucidated the role of different signaling cascades, especially the DAF-16 cascade, on lifespan extension by LAB. In this study, the mechanisms through which Bifidobacterium longum strain BB68 affects the longevity of C. elegans were assessed. The lifespan of nematodes increased by 28% after worms were fed BB68, and this extension of lifespan was completely lost in backgrounds containing a mutated DAF-16 gene. High levels of DAF-16 (in the daf-16 (mu86); muIs61 strain) nuclear accumulation and high expression of the SOD-3 gene (a DAF-16-specific target gene) were observed as a result of BB68 treatment. Immunofluorescence microscopy revealed that TIR-1 and JNK-1 are involved in the phosphorylation and activation of DAF-16. Thus, BB68 increased the longevity of nematodes by activating the TIR-1 – JNK-1 – DAF-16 signaling pathway, and the cell wall component of BB68 contributed to longevity.
Dielectric study on mixtures of ionic liquids
Authors: Thoms E. , Sippel P. , Reuter D. , Weiß M. , Loidl A. , Krohns S.
Published: August 2017

Ionic liquids are promising candidates for electrolytes in energy-storage systems. We demonstrate that mixing two ionic liquids allows to precisely tune their physical properties, like the dc conductivity. Moreover, these mixtures enable the gradual modification of the fragility parameter, which is believed to be a measure of the complexity of the energy landscape in supercooled liquids. The physical origin of this index is still under debate; therefore, mixing ionic liquids can provide further insights. From the chemical point of view, tuning ionic liquids via mixing is an easy and thus an economic way. For this study, we performed detailed investigations by broadband dielectric spectroscopy and differential scanning calorimetry on two mixing series of ionic liquids. One series combines an imidazole based with a pyridine based ionic liquid and the other two different anions in an imidazole based ionic liquid. The analysis of the glass-transition temperatures and the thorough evaluations of the measured dielectric permittivity and conductivity spectra reveal that the dynamics in mixtures of ionic liquids are well defined by the fractions of their parent compounds.
Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan
Authors: Liu Shih-An , Wang Chen-Chi , Jiang Rong-San , Lee Fang-Yi , Lin Wen-Jiun , Lin Jin-Ching
Published: August 2017

We investigated the relationship of different primary subsites together with their pathological features on the survival of oral cavity squamous cell carcinoma (OCSCC) patients. We retrospectively reviewed OCSCC patients and documented their demographic data, pathological features and clinical outcome. The Cox proportional hazard model was used to examine the influence of various pathological features on the prognosis in different subsites of oral cavity. There were totally 1,383 OCSCC patients enrolled for final analysis. Perineural invasion had a poor prognosis at the early stage of OCSCC patients especially those with primary at the tongue. In addition, lymphovascular invasion was associated with poor survival at the late stage especially those with primary at the buccal mucosa and the tongue. The impact of pathological features on the survival of OCSCC patients varied in different subsites. Further investigation is warranted to validate our finding in a multicenter study. Grouping the different markers to establish a prognostic scoring system may provide more accurate evaluation of the prognosis in OCSCC patients.
AOD: the antioxidant protein database
Authors: Feng Pengmian , Ding Hui , Lin Hao , Chen Wei
Published: August 2017

An antioxidant is a molecule that can prevent free radicals from causing damages in organisms. The increasing studies on antioxidants calls for a specialized database that is not readily available yet. To this end, in the present study, theAntioxidantDatabase (AOD) was developed to help researchers understand and reveal the biological functions of antioxidant proteins. AOD is freely available athttp://lin.uestc.edu.cn/AODdatabase/index.aspx. The current release of AOD consists of 710 antioxidant proteins. Information including taxonomy, source organism, subcellular location, gene ontology, catalytic activity and function of antioxidant proteins are all extracted from UniProtKB/Swiss-Prot and captured in AOD. In addition, two web-based tools for performing sequence similarity search and computationally identification of antioxidants were also integrated in AOD. We believe that AOD will greatly facilitate the researches on antioxidants.
Commensal microbiota maintains alveolar macrophages with a low level of CCL24 production to generate anti-metastatic tumor activity
Authors: Cheng Min , Chen Yongyan , Wang Liang , Chen Wen , Yang Ling , Shen Guodong , Xu Tingjuan , Shen Gan , Tian Zhigang , Hu Shilian
Published: August 2017

Microbiota maintains host tissue homeostasis and influences tissue-resident macrophages. However, the mechanisms by which commensal bacteria in regulating the alveolar macrophages remain unclear. Here, by using an antibiotic-treated (Abt) mouse model, we found commensal bacteria depletion induced lower frequencies and numbers of alveolar macrophages. This effect was accompanied by the altered levels of genes involved in several biological pathways, including M2 macrophage polarization, as determined by gene expression analysis. Alveolar macrophages from the Abt mice had higher protein and gene levels of Arg1, CCL24, IL-13, IL-10, IL-6 and IL-1β, which could be recovered to normal levels by reconstructing commensal bacteria in the upper respiratory of Abt mice. Moreover, alveolar macrophages performed significant enhancement of M2 functions, especially CCL24 secretion, in the Abt mice challenged with B16/F10 melanoma. Adoptive transfer of normal alveolar macrophages or antibody neutralization of CCL24 significantly recovered the decrease of γδT17 cells and rescued the defect anti-tumor response of Abt mice, indicating the elevated amount of alveolar macrophage-derived CCL24 inhibited γδT cell mediated anti-tumor response. In conclusion, we demonstrated the ability of commensal bacteria to maintain alveolar macrophages with a low level of CCL24 production, which was necessary for the normal anti-tumor response in the lung.
Bioresponsive-controlled release of methylene blue from magnetic mesoporous silica from the electrochemical detection of telomerase activity
Authors: Lu Minghua
Published: August 2017

An electrochemical sensing platform was designed to monitor telomerase activity in HeLa cells, using bioresponsively controlled cargo release from magnetic mesoporous silica nanocontainers (MMSNs).
Through-space Förster-type energy transfer in isostructural zirconium and hafnium-based metal–organic layers
Authors: Wang Zi , Liu Yuxiu , Wang Zhiye , Cao Lingyun , Zhao Yi , Wang Cheng , Lin Wenbin
Published: August 2017

Identical energy transfer rates in isostructural Zr and Hf metal–organic layers revealed dominant through-space energy transfer over the through-bond one.
Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant
Authors: Liu Yonghui , Wang Youzhi , Yu Fan , Zhang Zhenqing , Yang Zhimou , Zhang Wenpeng , Wang Peng George , Zhao Wei
Published: August 2017

We utilize the supramolecular self-assembling peptide of Nap-GDFDFDYDK to construct chemically programmed, self-assembling and self-adjuvant MUC1-based antitumor vaccines.
Photochromism and molecular logic gate operation of a water-compatible bis-glycosyl diarylethene
Authors: Chai Xianzhi , Fu You-Xin , James Tony D. , Zhang Junji , He Xiao-Peng , Tian He
Published: August 2017

The synthesis of a bis-glycosyl diarylethene derivative by click chemistry for the water-compatible photochromism and operation of molecular logic gates is reported.
Construction of a superior visible-light-driven photocatalyst based on a C3N4active centre-photoelectron shift platform-electron withdrawing unit triadic structure covalent organic framework
Authors: He Sijing , Rong Qinfeng , Niu Hongyun , Cai Yaqi
Published: August 2017

Through ingenious design of the molecular structure, we constructed a novel covalent organic framework as a visible-light photocatalyst with superior activity.
Efficient 2D double-quantum solid-state NMR spectroscopy with large spectral widths
Authors: Märker Katharina , Hediger Sabine , De Paëpe Gaël
Published: August 2017

STiC phase shifts enable the use of supercycled recoupling sequences for recording 2D DQ–SQ correlation spectra with arbitrary spectral widths.
Evidence and isolation of tetrahedral intermediates formed upon the addition of lithium carbenoids to Weinreb amides and N-acylpyrroles
Authors: Castoldi Laura , Holzer Wolfgang , Langer Thierry , Pace Vittorio
Published: August 2017

Trapping tetrahedral intermediates from Weinreb amides andN-acylpyrroles.
Covalent cross-linking as a strategy to generate novel materials based on layered (2D) and other low D structures
Authors: Rao C. N. R. , Pramoda K. , Kumar Ram
Published: August 2017

Covalent linking of 2D structures such as graphene, MoS2and C3N4by employing coupling reactions provides a strategy to generate a variety of materials with new or improved properties.
A novel metal–organic framework loaded with abundant N-(aminobutyl)-N-(ethylisoluminol) as a high-efficiency electrochemiluminescence indicator for sensitive detection of mucin1 on cancer cells
Authors: Jiang Xinya , Wang Zili , Wang Haijun , Zhuo Ying , Yuan Ruo , Chai Yaqin
Published: August 2017

Abundant luminophore N-(aminobutyl)-N-(ethylisoluminol) functionalized metal–organic framework was synthesized as a novel and high-efficiency electrochemiluminescence indicator.
Growth of two-dimensional rhenium disulfide (ReS2) nanosheets with a few layers at low temperature
Authors: Kim Saeah , Yu Hak Ki , Yoon Seokhyun , Lee Nam-Suk , Kim Myung Hwa
Published: August 2017

Single-crystalline ReS2 nanosheets with a few layers were vertically grown on a SiO2/Si wafer by a gas phase reaction process at ambient pressure.
Intriguing structural chemistry of neutral and anionic layered monoalkylphosphates: single-source precursors for high-yield ceramic phosphates
Authors: Bhat Gulzar A. , Kalita Alok Ch. , Murugavel Ramaswamy
Published: August 2017

A simple protocol for multi-gram synthesis of unstable and normally inaccessible phosphate monoesters ROPO3H2 is reported, apart from demonstration of their thermal instability and utility as starting materials for metal phosphate single source precursors.
Solvent effects on the excited-state double proton transfer mechanism in the 7-azaindole dimer: a TDDFT study with the polarizable continuum model
Authors: Yu Xue-fang , Yamazaki Shohei , Taketsugu Tetsuya
Published: August 2017

Solvent effects on the excited-state double proton transfer (ESDPT) mechanism in the 7-azaindole (7AI) dimer were investigated using the time-dependent density functional theory (TDDFT) method.
The recent achievements of redox-neutral radical C–C cross-coupling enabled by visible-light
Authors: Xie Jin , Jin Hongming , Hashmi A. Stephen K.
Published: August 2017

Visible-light-driven redox-neutral radical C–C coupling brings a powerful platform to achieve non-classical C–C connection in the absence of external reductants or oxidants through a photoredox electron shuttling cycle.
The ligand effect on the oxidative addition of dioxygen to gold(i)–hydride complexes
Authors: Gaggioli Carlo Alberto , Belpassi Leonardo , Tarantelli Francesco , Harvey Jeremy N. , Belanzoni Paola
Published: August 2017

The activation energy barriers of the O2 to [LAuH] oxidative addition, calculated by including spin–orbit coupling (SOC) effects, quantitatively correlate with the σ donation component of the L–AuH bond.
Proof of concept for continuous enantioselective liquid–liquid extraction in capillary microreactors using 1-octanol as a sustainable solvent
Authors: Susanti Susanti , Meinds Tim G. , Pinxterhuis Erik B. , Schuur Boelo , de Vries Johannes G. , Feringa Ben L. , Winkelman Jozef G. M. , Yue Jun , Heeres Hero J.
Published: August 2017

Separation of racemates in microreactors using liquid–liquid extraction with 1-octanol as the solvent is successfully demonstrated.
Designing the thermal behaviour of aqueous biphasic systems composed of ammonium-based zwitterions
Authors: Ferreira Ana M. , Passos Helena , Okafuji Akiyoshi , Freire Mara G. , Coutinho João A. P. , Ohno Hiroyuki
Published: August 2017

The design of the thermal behaviour – from an upper critical solution temperature (UCST) to a lower critical solution temperature (LCST) – of aqueous biphasic systems composed of water-soluble ammonium-based zwitterions.
Facile synthesis of a highly water-soluble graphene conjugated chlorophyll-a photosensitizer composite for improved photodynamic therapy in vitro
Authors: Zhang Hongyue , Cheng Jianjun , Li Wenting , Tan Guanghui , Wang Zhiqiang , Jin Yingxue
Published: August 2017

Graphene conjugated withp-bromo-phenylhydrazone-methyl pyropheophorbide-a (BPMppa, 683 nm), which is derived from a chlorophyll-aphotosensitizer, shows significantly improved water-solubility and PDT efficiency.
Ytterbium(iii)-catalyzed three-component reactions: synthesis of 4-organoselenium-quinolines
Authors: de Oliveira Isadora M. , Vasconcelos Stanley S. N. , Barbeiro Cristiane S. , Correra Thiago C. , Shamim Anwar , Pimenta Daniel C. , Caracelli Ignez , Zukerman-Schpector Julio , Stefani Hélio A. , Manarin Flávia
Published: August 2017

4-Organoselenium-quinolines were synthesizedviamodel multi-component Povarov reactions betweenp-anisidine, ethyl glyoxylate and ethynyl(phenyl)selane.
Shape control in concave metal nanoparticles by etching
Authors: Li Qiang , Rellán-Piñeiro Marcos , Almora-Barrios Neyvis , Garcia-Ratés Miquel , Remediakis Ioannis N. , López Núria
Published: August 2017

The shape control for Pt nanoparticles on HCl was investigated and a new description for concave nanostructures derived.
A hybrid molecule of a GFP chromophore analogue and cholestene as a viscosity-dependent and cholesterol-responsive fluorescent sensor
Authors: Ikejiri Masahiro , Mori Kenta , Miyagi Rina , Konishi Rino , Chihara Yoshiko , Miyashita Kazuyuki
Published: August 2017

Diarylmethylenated and cholestene-hybrid analogues of the GFP chromophore showed viscosity-dependent and cholesterol-responsive fluorescent properties.
Splitting a DNAzyme enables a Na+-dependent FRET signal from the embedded aptamer
Authors: Zhou Wenhu , Ding Jinsong , Liu Juewen
Published: August 2017

The Na+-specific Ce13d DNAzyme is rigid showing no global folding in the presence of Na+, but splitting it at the cleavage site enables its Na+-specific folding detected by FRET.
Development of a hollow carbon sphere absorber displaying the multiple-reflection effect to attenuate electromagnetic waves
Authors: Li Dong-Ping , Sun Yan-Chun , Wang Xuan , Wu Song , Han Shi-Cheng , Yang Ying
Published: August 2017

The development and use of hollow amorphous carbon spheres has been considered to be an efficient strategy to combat severe electromagnetic interference.
Adsorption characteristics of Cytochrome c/DNA complex Langmuir molecular assemblies at the air–water interface: a surface area-normalized isotherm study
Authors: Paul Pabitra Kumar , Che Dock-Chil , Hiroyuki Kishimoto , Araki Kento , Matsumoto Takuya
Published: August 2017

We present the formation of a complex molecular network consisting of highly water soluble λ-DNA and a redox protein, Cytochrome c (Cyt c), at the air–water interface by Langmuir–Blodgett technique.
Preparation and characterization of a TiO2-NT/SnO2–Sb tubular porous electrode with long service lifetime for wastewater treatment process
Authors: Xu Anlin , Dai Xiang , Wei Kajia , Han Weiqing , Li Jiansheng , Sun Xiuyun , Shen Jinyou , Wang Lianjun
Published: August 2017

We have studied the formation process of a novel TiO2-NTs/SnO2–Sb tubular porous electrode with a long service lifetime for the wastewater treatment process.
One-pot synthesis of hierarchical concave tetrapod Pd nanocrystals and their electrocatalytic properties
Authors: Li Dongxiao , He Xing , Su Manman , Zhao Yanxi , Li Jinlin , Huang Tao , Liu Hanfan
Published: August 2017

Hierarchical concave tetrapod Pd nanocrystals were synthesized by reducing Pd(acac)2 with CO, and oleylamine was responsible for this morphology.
Size-dependent optical and thermochromic properties of Sm3Fe5O12
Authors: Liu Huanhuan , Yuan Long , Qi Hui , Du Yanyan , Wang Shan , Hou Changmin
Published: August 2017

Reversible thermochromic inorganic materials of Sm3Fe5O12with different particle sizes have been synthesized by a conventional high temperature solid state reaction method (2.51 μm) and sol–gel method (0.16 μm).
A highly-flexible cyclic-decavanadate ligand for interconversion of dinuclear- and trinuclear-cobalt(ii) and manganese(ii) cores
Authors: Maruyama Tatsuya , Kikukawa Yuji , Sakiyama Hiroshi , Katayama Misaki , Inada Yasuhiro , Hayashi Yoshihito
Published: August 2017

The conformation of a cyclic-decavanadate ligand was reversibly transformed in response to the nuclearity of the central metal core.
2-Hydroxyeupatolide attenuates inflammatory responses via the inhibiting of NF-κB signaling pathways
Authors: Ke Zunli , Li Mingxia , Liu Xin , Tan Si , Zhou Zhiqin , Huang Cheng
Published: August 2017

2-Hydroxyeupatolide (2-HE), a sesquiterpene lactone, is a potential agent to improve LPS-induced acute mouse inflammation damage.
Microwave spectroscopic detection of flame-sampled combustion intermediates
Authors: Hansen N. , Wullenkord J. , Obenchain D. A. , Graf I. , Kohse-Höinghaus K. , Grabow J.-U.
Published: August 2017

Microwave spectroscopy was used to detect and identify combustion intermediates after sampling out of laboratory-scale model flames.
Superhydrophobic, highly adhesive arrays of copper hollow spheres produced by electro-colloidal lithography
Authors: Bazin Damien , Faure Chrystel
Published: August 2017

Arrays of copper hollow microspheres produced under electric fields display anti-wetting and super-adhesive properties without resorting to any chemical modification.
P2-type transition metal oxides for high performance Na-ion battery cathodes
Authors: Luo Chao , Langrock Alex , Fan Xiulin , Liang Yujia , Wang Chunsheng
Published: August 2017

Ni/Fe doping and atomic layer deposition are two effective methods to stabilize P2-type sodium manganese oxide cathodes.
In situ synthesis of ultrathin metal–organic framework nanosheets: a new method for 2D metal-based nanoporous carbon electrocatalysts
Authors: Huang Liang , Zhang Xueping , Han Yujie , Wang Qingqing , Fang Youxing , Dong Shaojun
Published: August 2017

Ultrathin ZIF-67 nanosheets are synthesized for the first time via a salt-template confined in situ growth strategy. And the directly carbonized Co,N-doped nanoporous carbon nanosheets greatly boost the oxygen reduction reaction (ORR) as well.
Graphene-based multiplexed disposable electrochemical biosensor for rapid on-farm monitoring of NEFA and βHBA dairy biomarkers
Authors: Tuteja Satish K. , Duffield Todd , Neethirajan Suresh
Published: August 2017

Label-free assay using electrodeposited antibody-conjugated graphene biointerface for dual detection of NEFA and βHBA from dairy cow blood samples.
Enhanced stability of a rubrene analogue with a brickwork packing motif
Authors: Li Jinfeng , Ni Zhenjie , Zhang Xiaotao , Li Rongjin , Dong Huanli , Hu Wenping
Published: August 2017

Compared to rubrene, the rubrene analogue exhibited a brickwork packing motif with enhanced stability.
A polydiacetylene-based colorimetric chemosensor for malondialdehyde detection: a food spoilage indicator
Authors: Kim Sangwan , Lee Sunjong , Ahn Yejin , Kim Hyun Ki , Koh Joonseok , Kim Sung Dong , Kim Bong-Gi
Published: August 2017

A polydiacetylene-based colorimetric sensor was devised to detect malondialdehyde as a food spoilage indicator.
Structural evidence of a phosphoinositide-binding site in the Rgd1-RhoGAP domain
Authors: Martinez Denis , Langlois d'Estaintot Béatrice , Granier Thierry , Tolchard James , Courrèges Cécile , Prouzet-Mauléon Valérie , Hugues Michel , Gallois Bernard , Doignon François , Odaert Benoît
Published: August 2017

Phosphoinositide lipids recruit proteins to the plasma membrane involved in the regulation of cytoskeleton organization and in signalling pathways that control cell polarity and growth. Among those, Rgd1p is a yeast GTPase-activating protein (GAP) specific for Rho3p and Rho4p GTPases, which control actin polymerization and stress signalling pathways. Phosphoinositides not only bind Rgd1p, but also stimulate its GAP activity on the membrane-anchored form of Rho4p. Both F-BAR (F-BAR FCH, and BAR) and RhoGAP domains of Rgd1p are involved in lipid interactions. In the Rgd1p–F-BAR domain, a phosphoinositide-binding site has been recently characterized. We report here the X-ray structure of the Rgd1p–RhoGAP domain, identify by NMR spectroscopy and confirm by docking simulations, a new but cryptic phosphoinositide-binding site, comprising contiguous A1, A1′ and B helices. The addition of helix A1′, unusual among RhoGAP domains, seems to be crucial for lipid interactions. Such a site was totally unexpected inside a RhoGAP domain, as it was not predicted from either the protein sequence or its three-dimensional structure. Phosphoinositide-binding sites in RhoGAP domains have been reported to correspond to polybasic regions, which are located at the unstructured flexible termini of proteins. Solid-state NMR spectroscopy experiments confirm the membrane interaction of the Rgd1p–RhoGAP domain upon the addition of PtdIns(4,5)P2 and indicate a slight membrane destabilization in the presence of the two partners.
Neurogenic Orofacial Weakness and Speech in Adults With Dysarthria
Authors: Solomon Nancy Pearl , Makashay Matthew J. , Helou Leah B. , Clark Heather M.
Published: August 2017

Purpose

This study compared orofacial strength between adults with dysarthria and neurologically normal (NN) matched controls. In addition, orofacial muscle weakness was examined for potential relationships to speech impairments in adults with dysarthria.

Method

Matched groups of 55 adults with dysarthria and 55 NN adults generated maximum pressure (P
max
) against an air-filled bulb during lingual elevation, protrusion and lateralization, and buccodental and labial compressions. These orofacial strength measures were compared with speech intelligibility, perceptual ratings of speech, articulation rate, and fast syllable-repetition rate.

Results

The dysarthria group demonstrated significantly lower orofacial strength than the NN group on all tasks. Lingual strength correlated moderately and buccal strength correlated weakly with most ratings of speech deficits. Speech intelligibility was not sensitive to dysarthria severity. Individuals with severely reduced anterior lingual elevation P
max
(< 18 kPa) had normal to profoundly impaired sentence intelligibility (99%–6%) and moderately to severely impaired speech (26%–94% articulatory imprecision; 33%–94% overall severity).

Conclusions

Results support the presence of orofacial muscle weakness in adults with dysarthrias of varying etiologies but reinforce tenuous links between orofacial strength and speech production disorders. By examining individual data, preliminary evidence emerges to suggest that speech, but not necessarily intelligibility, is likely to be impaired when lingual weakness is severe.
Noise Equally Degrades Central Auditory Processing in 2- and 4-Year-Old Children
Authors: Niemitalo-Haapola Elina , Haapala Sini , Kujala Teija , Raappana Antti , Kujala Tiia , Jansson-Verkasalo Eira
Published: August 2017

Purpose

The aim of this study was to investigate developmental and noise-induced changes in central auditory processing indexed by event-related potentials in typically developing children.

Method

P1, N2, and N4 responses as well as mismatch negativities (MMNs) were recorded for standard syllables and consonants, frequency, intensity, vowel, and vowel duration changes in silent and noisy conditions in the same 14 children at the ages of 2 and 4 years.

Results

The P1 and N2 latencies decreased and the N2, N4, and MMN amplitudes increased with development of the children. The amplitude changes were strongest at frontal electrodes. At both ages, background noise decreased the P1 amplitude, increased the N2 amplitude, and shortened the N4 latency. The noise-induced amplitude changes of P1, N2, and N4 were strongest frontally. Furthermore, background noise degraded the MMN. At both ages, MMN was significantly elicited only by the consonant change, and at the age of 4 years, also by the vowel duration change during noise.

Conclusions

Developmental changes indexing maturation of central auditory processing were found from every response studied. Noise degraded sound encoding and echoic memory and impaired auditory discrimination at both ages. The older children were as vulnerable to the impact of noise as the younger children.

Supplemental materials

https://doi.org/10.23641/asha.5233939
Translational plasma stomatology: applications of cold atmospheric plasmas in dentistry and their extension
Authors: Li He‐Ping , Zhang Xiao‐Fei , Zhu Xiao‐Ming , Zheng Miao , Liu Shu‐Fang , Qi Xuan , Wang Kai‐Peng , Chen Jian , Xi Xiao‐Qing , Tan Jian‐Guo , Ostrikov Kostya (Ken)
Published: August 2017

In recent years, translational plasma medicine (TPM), as a novel application area of plasmas, has attracted much attention of experts from both academic and clinical fields. State‐of‐the‐art of the lab‐scale research and clinical trials of the cold atmospheric plasmas (CAPs) in the stomatology are reviewed in detail from the direct and indirect applications of the CAPs. Based on the discussions concerning the relationship between the plasma stomatology and the plasma medicine, it is indicated that it would be an important reference for promoting the TPM starting from the fundamental and application studies in the field of dentistry, which is also one of the most three promising application fields of plasma medicine.
Analysis of drivers’ performance in response to potential collision with pedestrians at urban crosswalks
Authors: Jiang Xiaobei , Wang Wuhong , Bengler Klaus , Guo Hongwei , Li Chenggang
Published: August 2017

Protection of vulnerable road users has been an increasingly important requirement for today's autonomous vehicles. Analysis of drivers’ response to potential collision with pedestrians can provide guidance for vehicle evasive manoeuvre and data support for traffic collision modelling. Field traffic data were collected by video recording and image processing at urban midblock crosswalks in Beijing, China and Munich, Germany. The drivers’ response to vehicle–pedestrian conflict is discussed by deceleration and acceleration phases considering the lane‐based kinematics of vehicles. Some basic characteristics describing the driver behaviour in an evasive process are statistically analysed, including the yielding decision, space history of deceleration, deceleration rate choice, and accelerating behaviour. Results show significant differences in drivers’ yielding decisions. In addition, the onset of braking and the trend of the space history of average deceleration rate during the drivers’ approaching process have been quantitatively proposed. The contributing factors to driver's yielding behaviour are analysed by the Binary Logit Model. The behavioural differences address the needs to make intercultural adaptation when introducing new autonomous vehicle technologies to developing countries. This study provides a basis for establishing evasive decision corrections for drivers or driverless vehicles.
Signal processing for coal layer thickness estimation using high‐resolution time delay estimation methods
Authors: Thomas Shweta Benedict , Roy Lakshi Prosad
Published: August 2017

The coal mining research technology is gaining popularity in terms of thickness measurement of coal mining horizon. The main challenge is to improve a robust sensing method for estimating the coal layer thickness left on mine‐haulage way roofs for mine safety. This study addresses this challenge by step frequency continuous wave ground penetrating radar (GPR), whose resolution is dependent on bandwidth. To improve the time resolution of GPR signal, this study adopted four high‐resolution algorithms, which are also known as subspace methods, namely, estimation of signal parameter via rotational invariance techniques, multiple‐signal classification (MUSIC) algorithm, polynomial version of MUSIC, i.e. root‐MUSIC and root‐Min‐Norm. The performance of all these algorithms is compared with synthetic data generated by the plane wave model and full wave model. The results are presented in terms of resolution power as well as relative root‐mean‐square error on the estimated thickness.
Study of the characteristics of ohmic contact between metal electrodes and Cu2ZnSnS4 thin films
Authors: Long Bo , Lin Sile , Nsengiyumva Walter , Lin Lingyan
Published: August 2017

Selection of ohmic contacts to Cu2ZnSnS4 (CZTS) films is one of the most crucial tasks involved in the fabrication of efficient CZTS devices. In the present work, the formation of ohmic contact with the p‐type CZTS films was studied. The p‐type CZTS thin films were fabricated by thermal evaporation, followed by the subsequent sulphurisation in the atmosphere of N2 + H2 S (5%). Ag, In, Al and Ti were chosen as the metal electrodes of the CZTS‐based films. The characteristics of CZTS thin films and the structure of Mo/CZTS/M (M = Ag, In, Al and Ti) were investigated using XRD, Raman, SEM, and EDX, to name but a few. The ohmic contact property of the studied material was tested using an I –V characterisation system. The results showed that Al could form a high‐quality ohmic contact with the p‐type CZTS films among the metallic electrodes.
Usage of Janus green B for the improvement of the filling effect during replication process of nanoimprint nickel stamp
Authors: Zhang Ran , Zheng Yongguang , Liu Ze , Chu Jinkui
Published: August 2017

This work proposes a simple replication process of nanoimprint nickel stamp with the usage of Janus Green B (JGB) for the improvement of the filling effect to eliminate the voids forming in high aspect ratio nanotrenches during nanoelectroforming process. As JGB molecules tend to adsorb at the edge of the nanotrench with high electron density, the metal deposition rate is reduced at the edge of the nanotrench. Therefore, the voids are not formed due to the elimination of the sealing phenomenon during electrodeposition process. On the basis of the proposed process, a nickel nanoimprint stamp with six nanograting areas of 1.3 mm × 1.3 mm size, 200 nm pitch, 80 nm linewidth and 200 nm depth was replicated successfully. The experiment results demonstrate that the filling effect is gradually improved with the addition of JGB in the replication process of the nickel stamp.
Fabrication and characterisation of TiO2 anti‐reflection coatings with gradient index
Authors: Tian Li , Li Ling , Wu Min
Published: August 2017

Nano‐textured anti‐reflection (AR) films are designed elaborately to improve the transmittance character and to reduce the surface reflection loss. This work reports the gradient‐index titanium dioxide (TiO2) AR coatings (ARCs) with the thickness of 50–400 nm, which was deposited by radio‐frequency magnetron sputtering‐assisted with the oblique‐angle deposition technique on the low‐iron glass substrates. The technological parameters related with this deposition were discussed such as the base pressure and target–substrate distance, as well as the vapour incident angle. Then, optical characteristics of the graded‐index coating were discussed. An ellipsometric model was built to account for the structural and optical differences. The optimal thickness of the TiO2 ARC was about 250 nm. It exhibited a higher transmittance at the visible light regions over a large wavelength range than that of the primitive glass substrate. The value of refractive index for the TiO2 ARC was 2.245 at the wavelength of 632.8 nm.
Influence of Spark plasma sintering on the tetragonal phase of ZrO2‐NiO nanosized powders synthesised via oxidation of quenched melted Ni40‐Zr60 alloy
Authors: Messaoudene Redha , Saidi Djaffar , Boutarek‐Zaourar Naima , Drazenovic Béatrice , Zaid Bachir , Si Ahmed Abderrahmane
Published: August 2017

Composite ZrO2‐NiO powders synthesised, via the oxidation of Ni40‐Zr60 alloy, and ball milled to sizes below 90 nm were spark plasma sintered. The isotherm levels, above the monoclinic–tetragonal (m–t) transition temperature in ZrO2 (1170°C), were in the range 1200 and 1300°C. Microstructures with grain sizes between 100 and 900 nm were achieved. The X‐ray diffraction patterns of the sintered samples revealed that the m–t transformation in ZrO2 was preserved. The fraction of tetragonal phase, between 25 and 45%, increases with the isotherm level. Such partial stabilisation of the tetragonal phase is attributed to the presence NiO in ZrO2.
Sc(OTf)3-Catalyzed Oligomerization of Indole: One-Pot Synthesis of 2-[2,2-Bis(indol-3-yl)ethyl]anilines and 3-(Indolin-2-yl)indoles
Authors: Kumar Anil , Shelke Ganesh
Published: August 2017

Oligomerization of substituted indoles and N-methylindoles was investigated in the presence of catalytic amounts of scandium triflate in dichloromethane. Two types of indole oligomer, 2-[2,2-bis(indol-3-yl)ethyl]anilines and 3-(indolin-2-yl)indoles were obtained based on the substituent on indole ring. This study constitutes the first example of Sc(OTf)3-catalyzed oligomerization of indoles and gave good yield of 2-[2,2-bis(indol-3-yl)ethyl]anilines and 3-(indolin-2-yl)indoles.
Chain Length of Amphipathic-Type Thioesters Dramatically Affects Reactivity in Aqueous Amidation Reactions with Cysteine Esters
Authors: Otomo Ikumi , Watanabe Kanna , Kuroda Chiaki , Kobayashi Kenichi
Published: August 2017

The reaction of five amphipathic-type thioesters, CH3(CH2)
m
COS(CH2)
n
COONa (m + n = 12), with cysteine hexyl, butyl, and ethyl esters were studied in aqueous medium. Compounds with the thioester group in close proximity to the carboxylate moiety (m = 10, n = 2) afforded amides in almost quantitative yield, whereas no reaction proceeded by using compounds with the thioester group distant from the carboxylate. In contrast, no clear difference in yield was observed among the five amphipathic-type thioesters upon reaction with valine hexyl ester. The results indicate that the reaction is affected by both the position of the thioester group and the hydrophilic/hydrophobic properties of the amino acid side chain.
Management einer portassoziierten Vena-cava-superior-Thrombose im Rahmen eines Crohn-Schubes
Authors: Abel Ludwig , Uhde Britta , Dembinski Rolf , Schraepler Konstantin
Published: August 2017

Anamnese und klinischer Befund Eine 56-jährige Patientin entwickelte das ausgeprägte Bild einer oberen Einflussstauung, während sie bei akutem Schub eines M. Crohn hospitalisiert war. Führend waren Dyspnoe, Zyanose, Kopfschmerzen und ausgeprägte Schwellung von Gesicht, Hals wie auch oberer Extremität. Wenige Tage zuvor war ihr ein Portkatheter bei Malnutrition infolge des chronisch aktiven M. Crohn mit anhaltender Inflammation implantiert worden.

Untersuchungen Ein CT zeigte einen vollständigen thrombotischen Verschluss der V.-Cava-Superior ausgehend vom Portkatheter.

Diagnose Es bestand eine portassoziierte komplette Vena-Cava-superior-Thrombose mit oberer Einflussstauung bei zeitgleichem schwerem Schub eines M. Crohn mit Hämatochezien.

Therapie u. Verlauf Es erfolgte die lokale prolongierte Lyse analog dem Regime der CaVenT-Studie von 2012. Die Symptome der Einflussstauung waren rückläufig wie auch die Größe des Cavathrombus, die Hämatochezien nahmen kaum zu.

Folgerung Die lokale Lyse scheint eine sichere und effektive Therapie der portassoziierten Thrombose zu sein, insbesondere bei erhöhter Blutungsneigung.
Endocuff-assisted colonoscopy is associated with a lower adenoma miss rate: a multicenter randomized tandem study
Authors: Triantafyllou Konstantinos , Polymeros Dimitrios , Apostolopoulos Periklis , Lopes Brandao Catarina , Gkolfakis Paraskevas , Repici Alessandro , Papanikolaou Ioannis , Dinis-Ribeiro Mario , Alexandrakis George , Hassan Cesare
Published: August 2017

Background and study aims The Endocuff (ARC Medical Design, Leeds, UK) is a device that, when mounted on the tip of an endoscope, may assist with inspection of a greater surface of the colonic mucosa by pulling backwards, flattening, and stretching the colonic folds as the endoscope is gradually withdrawn. We aimed to compare the adenoma miss rates of Endocuff-assisted colonoscopy with those of conventional colonoscopy.

Patients and methods The included patients underwent same-day, back-to-back, (Endocuff-assisted colonoscopy as the index procedure followed by conventional colonoscopy or vice versa, randomly assigned 1:1) colonoscopies, performed by six endoscopists with documented adenoma detection rates > 35 %, in four tertiary endoscopy facilities.

Results We randomized 200 patients (mean age 61.2 years [standard deviation 9.8]; 86.5 % colorectal cancer screening surveillance cases). Overall, there were seven incomplete examinations using Endocuff and one with conventional colonoscopy (P = 0.03). Times for endoscope insertion (5.0 minutes [0.8 – 21.0] vs. 5.0 minutes [1.0 – 16.0]; P = 0.49) and withdrawal (6.0 minutes [3.2 – 29.0] vs. 6.0 minutes [3.1 – 17.0]; P = 0.06) were similar for Endocuff-assisted and conventional colonoscopy. We detected one cancer and 195 adenomas; 84 in the proximal colon. Endocuff-assisted colonoscopy showed significantly lower overall and proximal colon adenoma miss rates compared with conventional colonoscopy (14.7 % [8.0 % – 21.0 %] vs. 38.4 % [28.1 % – 48.6 %] and 10.4 % [1.8 % – 19.1 %] vs. 38.9 % [23.0 % – 54.8 %], respectively). No difference between the two arms was shown regarding advanced adenoma miss rates, either overall or in the proximal colon. There were no serious adverse events related to the procedures.

Conclusions In comparison with conventional colonoscopy, Endocuff-assisted colonoscopy has a significantly lower adenoma miss rate when performed by high-detector endoscopists. However, the incomplete colonoscopy rate with Endocuff is higher.

ClinicalTrials.gov Identifier: NCT02340065.
Childhood experience of nature influences the willingness to coexist with biodiversity in cities
Authors: Hosaka Tetsuro , Sugimoto Koun , Numata Shinya
Published: August 2017

Although efforts to promote biodiversity in cities around the world have increased, many wild animals (including vertebrates and invertebrates) comprising “urban biodiversity” are unpopular or often regarded as a nuisance by the general public, particularly by those city residents who have had little experience with nature. We conducted a questionnaire survey with 1030 urban residents in Japan to assess their likeability (like and dislike) towards 29 wild animals, and their willingness to have these animals in their neighbourhoods, and examined the effects of childhood experience of nature and socio-demographic factors on these attitudes. In general, people liked smaller birds and mammals, and some insects, but were only willing to have birds and insects near their homes. Females liked birds and mammals but disliked insects and unfavourable animals more than males. Older people expressed willingness to coexist with insects and birds more than younger people. However, childhood experience with nature, particularly collecting insects and plants, was a more important factor than socio-demographics for positive attitudes towards wild animals. Therefore, even though urban residents were unwilling to coexist with many animals, their attitudes can become more positive through increased interaction with wild animals and plants. Biodiversity conservation initiatives in cities should place greater emphasis on providing children with more interaction with biodiversity.
Electromagnetic properties of terbium gallium garnet at millikelvin temperatures and low photon energy
Authors: Kostylev Nikita , Goryachev Maxim , Bushev Pavel , Tobar Michael E.
Published: August 2017

Electromagnetic properties of single crystal terbium gallium garnet are characterised from room down to millikelvin temperatures using the whispering gallery mode method. Microwave spectroscopy is performed at low powers equivalent to a few photons in energy and conducted as functions of the magnetic field and temperature. A phase transition is detected close to the temperature of 3.5 K. This is observed for multiple whispering gallery modes causing an abrupt negative frequency shift and a change in transmission due to extra losses in the new phase caused by a change in complex magnetic susceptibility.
Investigation on the energy spectrums of electrons in atmospheric pressure argon plasma jets and their dependences on the applied voltage
Authors: Chen Xinxian , Tan Zhenyu , Liu Yadi , Li Xiaotong , Pan Jie , Wang Xiaolong
Published: August 2017

This work presents a systematical investigation on the spatiotemporal evolution of the energy spectrum of electrons in atmospheric pressure argon plasma jets and its dependence on the applied voltage. The investigations are carried out by means of the numerical simulation based on a particle-in-cell Monte-Carlo collision model. The characteristics of the spatiotemporal evolution of the energy spectrum of electrons (ESE) in the discharge space have been presented, and especially the mechanisms of inducing these characteristics have also been revealed. The present work shows the following conclusions. In the evolution of ESE, there is a characteristic time under each applied voltage. Before the characteristic time, the peak value of ESE decreases, the peak position shifts toward high energy, and the distribution of ESE becomes wider and wider, but the reverse is true after the characteristic time. The formation of these characteristics can be mainly attributed to the transport of electrons toward a low electric field as well as a balance between the energy gained from the electric field including the effect of space charges and the energy loss due to inelastic collisions in the process of electron transport. The characteristic time decreases with the applied voltage. In addition, the average energy of electrons at the characteristic time can be increased by enhancing the applied voltage. The results presented in this work are of importance for regulating and controlling the energy of electrons in the plasma jets applied to plasma medicine.
Excitation of coherent propagating spin waves in ultrathin CoFeB film by voltage-controlled magnetic anisotropy
Authors: Rana Bivas , Fukuma Yasuhiro , Miura Katsuya , Takahashi Hiromasa , Otani YoshiChika
Published: August 2017

Spin waves (SWs) may be used as potential information carriers in next generation low-power spintronics devices. Here, we report an experimental study on the excitation of propagating magnetostatic surface SWs by voltage-controlled magnetic anisotropy in a 2 nm thick CoFeB film. The SWs are detected by a pico-second time-resolved longitudinal Kerr microscope with a spatial resolution of 600 nm. We found a linear increase in the SW amplitude with the applied rf voltage. We show that in this ultrathin film, the voltage excited SWs can propagate up to micrometer distances which decrease with the increase in the bias magnetic field value. This is also supported by micromagnetic simulation results. Furthermore, we show that voltage excitations are spatially localized as opposed to conventional microstrip antenna induced Oersted field excitations. We discuss about the advantage of voltage excitation compared to the Oersted field excitation. We believe that voltage excitation of SWs will be more suitable and useful for the development of all-voltage-controlled nanoscale spintronics devices with a high density of integration.
Enhanced ultrasonic focusing and temperature elevation via a therapeutic ultrasonic transducer with sub-wavelength periodic structure
Authors: Li Chenghai , Yang Yanye , Guo Xiasheng , Tu Juan , Huang Pintong , Li Faqi , Zhang Dong
Published: August 2017

In this paper, we report a therapeutic ultrasonic transducer with a sub-wavelength periodic structure, by which ultrasonic focusing and temperature elevation have been significantly enhanced compared to a conventional concave transducer with the same size. Enhanced acoustic focusing was demonstrated by both measuring and simulating acoustic pressure and temperature elevation. Compared to the conventional concave transducer, the proposed transducer exhibited stronger capacity in elevating acoustic pressure and temperature rise in the focal region, in which extraordinary acoustic transmission close to Wood's anomaly could be modulated by the spherically curved surface. This work is believed to possess great clinical potential in the safe and efficient application of ultrasonic therapy.