bluuebunny/crossref_metadata_2025 huggingface dataset:
The association between nocturia, hormonal symptoms and bladder parameters in women: an observational study.
Authors: Bower Wendy , Rose Georgie , Whishaw David , Ervin Claire , Wang Audrey , Moore Kate
Published: November 2020

Objective Post-menopausal nocturia is poorly understood. This study
aimed to identify hormonal and lifestyle factors associated with
nocturia and to understand the relative contribution of altered urine
production and bladder storage dysfunction in women. Design, setting,
population and methods Women ≥40 years presenting to public continence
services were enrolled in a cross-sectional study. 153 participants
completed a hormone status questionnaire, a validated nocturia causality
screening tool and a 3-day bladder diary. Descriptive statistics and
logistic regression models for nocturia severity and bladder diary
parameters were computed. Results Overall, 91.5 % reported nocturia,
55% ≥2 /night. There was a difference of 167.5 mL (p<0.001)
in nocturnal urine volume between women with nocturia ≥2 (median 736mL)
vs less often (517mL). Significant predictors of self-reported
disruptive nocturia were age (OR 1.04, 95%CI 1.002-1.073) and vitamin D
supplementation (OR 2.33, 95%CI 1.11-4.91). Nocturnal polyuria was
significantly more common with nocturia ≥2 compared to less often
(p<0.002). 150 minutes of exercise per week was protective for
nocturnal polyuria (OR 0.22, p=0.001). Nocturia index >1.3
was significantly predicted by age (OR 1.07, p<0.001), regular
exercise (OR 0.41, p=0.036), day flushes (OR 4.00, p=0.013) and use of
Vitamin D (OR 2.34, p=0.043). Maximum voided volumes were significantly
lower with nocturia≥2 vs less often (night: 268ml vs 350mL; day: 200mL
vs 290mL). Conclusions Bothersome nocturia in post-menopausal women is
associated with changes to both nocturnal diuresis and bladder storage.
Regular physical activity, prolapse reduction and oestrogen replacement
may be adjunctive in managing bothersome nocturia in women.
COVID-19: Animal Epidemiology and Zoonotic risk
Authors: Ferri Maurizio , Yong Shin Jie
Published: November 2020

The COVID-19 pandemic represents one of the greatest public health
crises in recent history that caused unprecedented and massive
disruptions of social and economic life globally. It is widely
acknowledged that bats are the animal reservoir of coronavirus 2 of the
severe acute respiratory syndrome (SARS-CoV-2), the causative agent of
the human coronavirus disease 2019 (COVID-19). It has also long been
known that coronaviruses circulate among different animal species.
However, much remain to be understood of the epidemiology, the presumed
existence of intermediate animal species and current and potential
animal routes of SARS-Cov-2 transmission to humans. The recent
observational and experimental studies also highlight the role of
domestic and farmed animals in the epidemiology of COVID-19. This raises
concerns of the potential spread of infection among susceptible animal
species, with the risk of evolving into panzootic, and the likely
occurrence of anthropozoonoses or reverse zoonosis (from humans to
animals). As for other wildlife emerging pathogens, the animal-human
spillover of SARS-CoV-2 is linked to a closer interface with humans,
with the resulting risk of a pandemic. This knowledge has meaningful
implications for the design of effective wildlife animal surveillance
(epidemic intelligence) targeting CoVs in animal reservoirs, and
requires the mobilization of different lines of expertise, notably
veterinary epidemiologists and virologists, within a multi-disciplinary
approach according to the One-Health principles.
Energy selection functions: modelling the energetic drivers of animal movement and habitat use
Authors: Klappstein Natasha J. , Potts Jonathan , Michelot Théo , Börger Luca , Pilfold Nicholas , Lewis Mark , Derocher Andrew
Published: November 2020

Energetics are a key driver of animal decision-making, as survival
depends on the balance between foraging benefits and movement costs.
This fundamental perspective is often missing from habitat selection
studies, which mainly describe simple correlations between space use and
environmental features. To address this gap, we present a new model, the
energy selection function (ESF), to assess how moving animals choose
habitat based on energetic considerations, thus incorporating a key
aspect of evolutionary behaviour into habitat selection analysis. We
outline a workflow, from data-gathering to statistical analysis, and
demonstrate the model’s utility with a case study of polar bears. Our
findings show how cost-minimization may arise in species that inhabit
environments with an unpredictable distribution of energetic gains.
Because of its close links to existing habitat selection models, the ESF
is widely applicable to any study system where energetics can be
derived, and has immense potential for methodological extensions.
Outcomes of a combined vs non-combined endoepicardial ventricular tachycardia ablation strategy
Authors: Matos Daniel , Adragão Pedro , Pisani Cristiano , Hatanaka Vinicius , Freitas Pedro , Costa Francisco , Chokr Muhieddine , Hardy Carina , Ferreira Antonio , Carmo Pedro , Lara Sissy , Cavaco Diogo , Morgado Francisco , Mendes Miguel , Scanavacca Mauricio Ibrahim
Published: November 2020

BACKGROUND Direct comparisons of combined (C-ABL) and non-combined
(NC-ABL) endo-epicardial ventricular tachycardia (VT) ablation outcomes
are scarce. We aimed to investigate the long-term clinical efficacy and
safety of these 2 strategies in ischemic heart disease (IHD) and
nonischemic cardiomyopathy (NICM) patients. METHODS Multicentric
observational registry including 316 consecutive patients who underwent
catheter ablation for drug-resistant VT between January 2008 and July
2019. Primary and secondary efficacy endpoints were defined as VT-free
survival and all-cause death after ablation. Safety outcomes were
defined by 30-days mortality and procedure-related complications.
RESULTS Most of the patients were male (85%), with IHD (67%) and mean
age of 63±13 years. During a mean follow-up of 3±2 years, 117 (37%)
patients had VT recurrence and 73 (23%) died. Multivariate survival
analysis identified electrical storm (ES) at presentation, IHD, left
ventricular ejection fraction (LVEF), New York Heart Association (NYHA)
class III/IV, and C-ABL as independent predictors of VT recurrence. In
135 patients undergoing repeated procedures, only C-ABL and ES were
independent predictors of relapse. The independent predictors of
mortality were C-ABL, ES, LVEF, age and NYHA class III/IV. C-ABL
survival benefit was only seen in patients with a previous ablation (P
for interaction=0.04). Mortality at 30-days was similar between NC-ABL
and C-ABL (4% vs. 2%, respectively, P=0.777), as was complication rate
(10.3% vs. 15.1% respectively, P=0.336). CONCLUSION A combined
endo-epicardial approach was associated with greater VT-free survival
and lower all-cause death in IHD and NICM patients undergoing repeated
VT catheter ablations. Both strategies seem equally safe.
ECONOMIC COSTS OF HOSPITALIZATION AND LENGTH OF STAY IN DIABETES WITH CO-EXISTING HYPERTENSION WITH CORRELATION TO LABORATORY INVESTIGATIONS: WHERE DOES INDIA STAND? A FIVE YEARS GROUND REPORT
Authors: Sharma Amit , Baldi Ashish , Sharma Dinesh Kumar
Published: November 2020

Introduction: The coexistence of diabetes mellitus (DM) and hypertension
(HTN) worsen clinical outcomes and contribute to increased morbidity and
mortality. Objective: This study aims to analyze the length of stay and
healthcare costs by calculating the direct and indirect costs of
diabetes with co-existing hypertension in North India. Methods: A
prospective observational study was conducted at the medicine department
of the three different hospitals. Results: The patients’ mean age was
found to be (M=53.8, SD=11.5) years. Out of 1914 patients, 53.65% were
found female. Our study revealed that the median cost of medical
supplies and equipment was found to be 21.2 $. The median cost of
dialysis was found at 47.5 $; the median cost of hospitalization was
found to be 142.6 $. The treatment’s median direct cost was 188.5 $,
followed by the overall median cost of 295.6 $. The maximum overall
cost of treatment was observed at 603.9 $. It was observed that that
maximum LOS was found to be 14 days for patients having BPS between 140
to 159 mmHg and BPD between 110- 119 mmHg, and minimum LOS was found to
be 3.5 days. Conclusion: The present study highlighted that diabetes
co-existing hypertension poses a high economic burden on patients. This
study explored that highly significant result for BPS, BPD, FBS, and
HbA1c, whereas the significant results were obtained when RBS is
compared with LOS and treatment costs. Our study concluded that mean
difference of 9.24 $ in patients having FBS: 261-290 mg/dl and
> 290 mg/dL. The LOS increases 6.57 days for patients with
BPS between 140-159 mmHg compared to BPS between 180 -above 209 mmHg,
which lower treatment costs by -21.31$. Keywords: Diabetes,
Hypertension, length of stay, cost of treatment, direct medical cost,
indirect medical cost
Fixed point results for Suzuki Type Σ-contractions via simulation functions in modular b-metric spaces
Authors: ÖZTÜRK Mahpeyker , Buyukkaya Abdurrahman
Published: November 2020

This study aims to introduce Suzuki type Σcontraction mappings with
simulation functions in the frame of modular b-metric spaces. Also, some
coincidence and common fixed point results are obtained for four
mappings using the weakly compatibility property that these results are
the extensions and improvements of the existing literature. Finally, we
also present two applications on graph theory and homotopy theory, which
show applicability and validity of our results.
Sublingual immunotherapy for pollen allergic rhinitis: a systematic review and meta-analysis
Authors: Feng Lufang , Cao Liujiao , Yan Peijing , Chu Xiajing , Zhang Na , Chen Nan , Liu Xingrong , yang kehu
Published: November 2020

Intro Allergic rhinitis（AR） is a common condition which can
significantly impair quality of life. This study aimed to illustrate the
efficacy and safety of sublingual immunotherapy (SLIT) on pollen AR
patients. Methods Four electronic databases (PubMed, EMBASE, Cochrane
Library, and Web of Science) were searched from their inception until
September 2019. Two reviewers （FLF and CLJ） independently extracted
the data. The Cochrane’s Risk of Bias tool was used to assess the
quality of included studies. The outcomes of study were calculated by MD
or SMD with 95%CI. A meta-analysis was performed using RevMan 5.3
software. Results In this systematic review, a total of 8 articles were
included, involving 785 participants. The quality of the included
studies ranged from low to moderate. The results of the meta-analysis
showed that compared with placebo, a significant reduction of nasal
symptoms were observed on SLIT (MD = −0.84, 95% CI = −1.47 to −0.22, P
< 0.05), IgE (SMD =0.46, 95% CI = 0.16 to 0.76, P <
0.05); No significant effect on medication scores (MD = −0.41, 95% CI =
−0.89 to 0.07, P =0.10). No serious adverse events were reported, and
symptoms of adverse events were reported more frequently in the
gastrointestinal symptoms. Conclusion SLIT can effectively relieve
rhinitis symptoms and decrease the level of specific-IgE for pollen
allergic rhinitis patients and the safety was verified. But due to the
low quality of studies, more high-quality randomized trials are needed
to provide stronger evidence of the conclusion.
The effect of graduated elastic compression stockings on clinical findings, complications and inflammatory and thrombotic markers in patients with superficial vein thrombophlebitis
Authors: Markovic Dragan , Vasic Dragan , Mutavdzic Perica , Cvetkovic Slobodan , Popovic Vladan , Davidovic Lazar
Published: November 2020

Introduction/Objective. The objective of the paper is an assessment of the effect of graduated elastic compression stockings on clinical findings, complications, and inflammatory and thrombotic markers in patients with superficial vein thrombophlebitis. Methods. This prospective study was conducted between January and July of 2017, at the Clinic for Vascular and Endovascular Surgery of the Clinical Centre of Serbia. All the patients were clinically examined, and color duplex ultrasonography of the superficial and deep venous systems was performed. In all cases, we follow clinical finding, inflammatory and thrombotic markers, and superficial vein thrombosis (SVT) complication. Results. SVT was detected in 60 patients (36 women, aged 23?75 years and 24 men, aged 18?76 years. Most patients were with unilateral, subacute, above-knee located SVT. Regarding the typical clinical symptoms of SVT, patients were divided into four groups. The majority of our patients (group D) had all the symptoms associated. Regarding the severity of SVT and risk factors, the patients were divided into a greater risk group (Group I) and a lesser risk group (Group II), and treated with low-molecular-weight heparin, aspirin and two classes of graduated elastic compression stockings regarding the level of SVT. Laboratory testing of inflammatory and thrombotic markers in patients with SVT was performed at the beginning and at the end of therapy. Conclusions. In treatment of SVT, higher class of graduated compression therapy has stronger influence in decrement of inflammatory and thrombotic factors and prompt and adequately chosen therapy of SVT allows stoppage and regression of the thrombotic process.
Effect of thermal cycling on mechanical properties and energy evolution of sandstone
Authors: Hou Peng , Gao Lin , Xing Yan , Zhang Zhao-Peng
Published: November 2020

In geothermal energy exploration, the reservoir rock is always subjected to
thermal cycles and its physical properties will be seriously affected. In
this paper, the changes of the internal structure of the sandstone after the
thermal cycle are firstly evaluated by ultrasonic tests. Then, uniaxial
compression tests are conducted on the treated specimens. The effects of the
thermal cycling on mechanical properties and energy evolution law of the
sandstone are analyzed. The results show that the density, P-wave velocity
and mechanical properties of the sandstone reduced with the increase in the
thermal cycle, especially in the high temperature cycle. The increase of the
temperature in the thermal cycle can increase the influence of the thermal
cycle on the energy evolution law.
On traveling-wave solutions for the scaling-law telegraph equations
Authors: Yang Xiao-Jun
Published: November 2020

The aim of the study is to address the scaling-law telegraph equations with
the Mandelbrot-scaling-law derivative. The traveling-wave solutions with use
of the Kohlrausch-Williams-Watts function are considered in detail. The
works are proposed to describe the physical models in complex topology.
Ground subsidence mechanism analysis of Longgui salt rock mining area: Case study
Authors: Zhang Nan , Yang Jie , Shi Xi-Lin , Li Yin-Ping , Chen Jian , Liu Wei
Published: November 2020

The water-soluble mining is often accompanied by ground subsidence, which
could result in the severity of ground subsidence disasters. The roof of the
salt-bearing strata in the Longgui salt rock mining area is close to the
third aquifer, which is mostly composed of muddy conglomerate and other
porous rocks with large porosity and permeability. The water-soluble mining
for many years has caused serious ground subsidence in the mining area, and
there is a tendency to accelerate subsidence. Taking Longgui salt rock mine
as a case, the mining subsidence mechanism was analyzed and discussed
through the water dissolution simulation test. This study is of great
significance to the prevention and control of ground subsidence disasters in
Longgui salt rock mine, and also has certain reference value for other
similar mining areas.
On distribution characteristics of the temperature field and gas seepage law of coal in deep mining
Authors: Yang Ming-Qing , Xie He-Ping , Gao Ming-Zhong , He Zhi-Qiang , Li Cong , Xie Jing , Lu Yi-Qiang , Yang Ben-Gao
Published: November 2020

The study of gas seepage under the condition of multifield coupling has
always been an important topic in coal mining. Based on the theory of
multifield coupling and the research method of numerical simulation, the
influences of the stress and temperature fields on the seepage field under
the conditions of deep coal mining are studied. With the example of the
J15-31030 deep working face from mine No. 12 in the Pingdingshan Coal Mine,
modeling and finite element analysis are carried out. The influences of the
mining stress field and temperature field on the gas seepage field are
preliminarily revealed. The results show that the closer to the working
face, the greater the velocity of the seepage field is, and the greater the
gradient of velocity change. There is a clear negative correlation between
the mining stress field and the permeability of the seepage field. The
larger the excavation length is, the greater the change gradient of the rock
permeability near the working face is. The temperature field has a
significant impact on the adsorbed gas in the seepage field. These research
results provide the corresponding basis for the safety control and effective
mining of coal mine gas.
Refractory Multi-Inflammatory Syndrome in a Two Weeks Old Neonate with COVID-19 Treated Successfully with Intravenous Immunoglobulin, Steroids and Anakinra
Authors: S Magboul
Published: November 2020

Background: World Health Organization (WHO) and other Health officials alert clinicians about a rare but severe inflammatory condition seen in children and linked to Corona Virus Disease 2019(COVID-19). The WHO is describing the condition as a multisystem inflammatory syndrome in children (MIS-C) and is recommending clinicians to report those cases to get a better understanding of the disease and clinicians can learn more. Case Presentation: We are reporting the clinical course of the youngest case of COVID-19 related MIS-c; a two-week-old term neonate with COVID-19 infection and features suggestive of MIS-C, managed with intravenous immunoglobulin (IVIG), pulse steroid, and interleukin-1 inhibitor (Anakinra). By reviewing the literature, our baby is the first neonatal case who has been diagnosed with MIS-C. Conclusion: COVID-19 infections in pediatrics are likely to present with a mild course; however, some may develop a hyperinflammatory syndrome. Pediatricians should be aware of such presentation, the clinical course, the management modalities,and inform parents and caregivers about common signs and symptoms. Anakinra may consider as effective second agent in (IVIG and steroid-refractory pediatric cases).
Collaboratory, Coronavirus and the Colonial Countryside
Authors: Williams Howard
Published: November 2020

Introducing the second volume of the Offa’s Dyke Journal (ODJ), this five-part article sets the scene by reviewing: (i) key recent research augmenting last year’s Introduction (Williams and Delaney 2019); (ii) the key activities of the Offa’s Dyke Collaboratory in 2020; (iii) the political mobilisation of Offa’s Dyke in the context of the COVID-19 pandemic lockdowns; (iv) the ramifications of accelerated efforts to decolonise the British countryside on both archaeological research and heritage interpretation on linear monuments; and (v) a review of the contents of volume 2. Together, this introduction presents the context and significance of ODJ volume 2 for both research on the Welsh Marches and broader investigations of frontiers and borderlands.
PESCO, CARD, EDF: Strategy, Analysis, and Financing in the European Union Security Guaratee
Authors:   Lviv Polytechnic National University, Dorosh Lesia , Romanyk Vasyl
Published: November 2020

In the article the authors analyze the institutional basis for strengthening the EU security and the implementation of specific projects designed to expand cooperation between the Member States in the defence and security sectors. The point at issue is about Permanent Structured Cooperation (PESCO); the Coordinated Annual Review on Defence (CARD) and the European Defence Fund (EDF). The relevance of the comprehensive study of PESCO, CARD, EDF, which activities are aimed at ensuring the strategic component of cooperation, the analysis of the defence sector and funding priorities in the security sphere of the Union have been proved. The authors claim that PESCO has become a key strategic initiative of the EU, CARD allows coordinating the development of military capabilities in the Member States; the EDF was created to coordinate, increase investment and improve defence interoperability between EU member states. The challenges faced within the functioning of these initiatives have been analyzed. It is alleged that a key challenge for the CARD is the unwillingness of Member countries to share national defence plans, as well as the available and potential coordination and harmonization of defence planning within NATO’s Defence Planning. The peculiarities of specific projects financed within the European Defense Fund (“Ocean 2020”, “Eurodrone”, “SPIDER”, “EuroSWARM”, “TRAWA”, “ACAMSII”, “Gossra”, “Vestlife”) have been analyzed. There is continued progress in the field of the EU security and defence: numerous defence projects have been initiated under PESCO; there is a synchronization of defence planning through the CARD; the investments in defence are stimulated by financing the defence research projects through the EDF, the improving military mobility is continuing; coordination of the EU-NATO cooperation is improving, etc.
European Union's Initiatives in the Struggle against the Propaganda of Terrorism
Authors:   Lesya Ukrainka Eastern European National University, Karpchuk Nataliia
Published: November 2020

In the article, the author analyzes the EU initiatives that prevent radicalization, reduce the impact of destructive content, and increase public awareness and the ability to distinguish objective information from fakes and disinformation. The author emphasizes that the EU’s struggle against radicalization, extremism and terrorism is based on four “pillars”: 1) prevention, 2) protection, 3) persecution and 4) response. Each Member State develops its own prevention policy, but the Commission provides some regulatory framework for the exchange of experiences and good practices, so special attention is paid to the study of the Radicalization Awareness Network (RAN), which is an EU policy tool because it is aimed at developing programs of deradicalization and rehabilitation, assistance to teachers and youth in combating the causes of radicalization. The author argues that only the common efforts of the EU institutions, Member States, partner countries, media and technological organizations can effectively struggle against the propaganda of extremism and terrorism.
Weissellosis in rainbow trout in Colombia
Authors: Vásquez-Machado Gersson , Rubiano-Garzón Miguel , Yepes-Blandón Jonny , Gordillo-González Daniel , Avila-Coy Jersson
Published: November 2020

Weissellosis is an emergent disease caused by Weissella, a Gram-positive bacteria correlated with hemorrhagic illness and mortality in farm-raised trout in several countries. The current study reports the first outbreaks of weissellosis by Weissella ceti in rainbow trout (Oncorhynchus mykiss), which caused severe mortalities in trout farms in Colombia between May 2016 to June 2019. The disease occurred in several farms irrigated by the same river where temperatures were above 17 °C. Symptoms of the disease were limited almost exclusively to trout above 250 g. The clinical signs consisted of lethargic and anorexic fish, swimming in circles at the surface or against the walls. Pathological findings were mainly ocular lesions like bilateral exophthalmia, periocular and intraocular hemorrhage, lenticular opacity and corneal rupture usually leading to blindness, muscular hemorrhages and necrosis. Microbial isolating from eye, brain, kidney, liver and muscle was performed and W. ceti was confirmed by amplification and sequencing of the 16S rRNA. The aim of this work was to characterize the Weisellosis by Weissella ceti in trouts in Colombia, including microbiological isolating, molecular analysis, gross and microscopic characterization.
Mammary carcinoma in a mixed tumor with myeloid metaplasia component presenting Leishmania spp. in a dog
Authors: Arenales Alexandre , Ferreira Jefferson , Almeida Ana Carolina , Rozza Daniella , Luvizotto Maria Cecília
Published: November 2020

Here is described a 9-years-old, intact female dog with cytopathological analysis from mammary tumors containing Leishmania spp. amastigotes in macrophages. The animal was submitted to euthanasia and necropsy was performed. Histopathological diagnosis was a mammary carcinoma in a mixed tumor, grade I, with myeloid metaplasia component containing macrophages laden with a large amount of amastigotes. For confirmation, immunohistochemistry was used in neoplastic tissue and resulted in strong positivity for Leishmania antibody. Myeloid metaplasia portion of mammary carcinoma in a mixed tumor may be, rarely, a site for diagnosis of Canine Visceral Leishmaniasis.
Relationship between Leadership Style and Hospital Employee Engagement in Papua New Guinea
Authors: Muddle Grant Robert
Published: November 2020

Engagement, an important concept in the determination of overall employee output, has become an important factor within the healthcare sector, and in light of various challenges facing employees, such as high workloads and long working hours, engagement also plays a significant role in ensuring improved healthcare output. Meanwhile, leadership, which plays a major role in guiding and influencing employees toward goal achievement, is the driving force behind employee engagement. Accordingly, the purpose of this study was to examine the nature of the relationship between three different leadership techniques—transformational, transactional and passive avoidant—and employee engagement in the Papua New Guinea (PNG) healthcare sector. Research has shown that transactional and transformational leadership have the highest level of impact on employee engagement as a result of the role leaders play in the inspiration and stimulation of employees. The methodology applied to examine this statement involved a random selection of 84 health employees from three PNG hospitals: ANGAU Memorial Provincial Hospital, Mount Hagen General Hospital and Port Moresby General Hospital. A correlation analysis of the quantitative research methodology was then applied to evaluate the relationship between key variables in the collected data. A final analysis of results revealed that, within the PNG healthcare sector, transformational and transactional leadership both have a positive relationship with employee engagement, while passive avoidant leadership has a negative relationship with employee engagement.
Health as An Economic Dimension: A comparative study of India and China
Authors: Yadav Manju
Published: November 2020

In modern era, human resource is a crucial factor for economic development. Several studies reveal that rapid economic growth of developed countries has been linked with investment in human capital. Efficient and proper management of the workforce is an important factor in development of a country. The importance of human capital formation is now fully recognized because healthy and skilled people, along with physical capital, help in capital formation and raising economic growth. Therefore, large scale investment in human capital is required for the full and optimum use of natural resources. Improvement in the health of masses increases their productive capacity and leads to quantitative improvement in human capital. This paper examines the role of health facilities in human capital formation as well as in economic development. The current study analyzes the trends of current health expenditure as percent of GDP in India and China. An effort has been made to compare the impact of health expenditure on value added per worker in agriculture and its allied sectors in India and China by employing multiple regression model using data from 2000 to 2017. Findings reveal that independent variable (current health expenditure) explains the variation in dependent variable (value added per worker) to an extent of 37.9% and 56.9% in India and China, respectively.
Etika Komunikasi Visual: Pencarian Kebenaran Dalam Pemahaman Antara Yang Dilihat Dan Yang Dipikirkan
Authors: Hardiyarso St.
Published: November 2020

Dalam proses pertukaran informasi, komunikator adalah sumber dari adanya ide rasional untuk sebuah pesan. Supaya sampai pada pihak yang dituju, komunikan, pesan tersebut harus disampaikan melalui media-media komunikasi. Di antara sekian banyak media, media visual sebagai pengantar pesan sekarang dipandang sebagai yang paling efektif, karena mengandalkan pencerapan indera penglihatan dan mengurangi pemahaman rasio. Efektifitas komunikasi visual menjadi nyata, ketika komunikan mampu menangkap dan mencerap makna pesan visual secara kritis rasional dan objektif, sesuai dengan gagasan rasional asali dari komunikator. Akan tetapi, tidak jarang terjadi, bahwa faktor ketiga, situasi di sekitar komunikan dan komunikator pun memberi pengaruh dalam proses komunikasi visual. Akibatnya, tidak ada kesepadanan antara persepsi rasional, media dan pencerapan visual oleh komunikan, yang biasa disebut sebagai miss-komunikasi. Dampak dari kesalahan dalam pemahaman tentunya akan menentukan perilaku. Memang, komunikasi diadakan dengan tujuan untuk mempengaruhi. Supaya tidak terjadi kondisi saling mempersalahkan, atau mencari “kambing hitam”, pengkajian secara filosofis atas dinamika komunikasi visual dipandang perlu untuk menemukan prinsip-prinsip dasar komunikasi visual. Sebagai kajian filsafati, metode yang dipergunakan adalah metode sistematis-spekulatif yang menekankan cara berpikir refleksif rasional dengan dukungan metode interpretatif dan komparatif secara holistik filsafati. Melalui metode ini, proses komunikasi visual diperbandingkan dengan proses pencarian pengetahuan oleh para filsuf, terutama Plato dan Aristoteles. Hasil kajian menunjukkan bahwa sumber kesalahpahaman komunikasi dapat berasal, baik komunikator, komunikan maupun faktor ketiga, lingkungan. Kesalahan tersebut pun dapat dibedakan, apakah disengaja atau tidak. Kesengajaan dimaksudkan untuk mencari keuntungan; dan ketidaksengajaan terjadi, karena kesalahan dalam cara berpikir, misalnya persepsi inderawi dipahami sebagai persepsi rasional, dan sebaliknya.
Cultural adaptation of MAB-II (Multidimensional Aptitude Battery) in Romania
Authors: Iliescu Dragoș , Glință Florin , Ispas Dan
Published: November 2020

This study examined the cultural adaptation of the Multidimensional Aptitude Battery II in Romania. Cultural adaptation of the items and the standardization process are described. The psychometric characteristics of the Romanian version are shown to be excellent in terms of reliability and construct validity (intertest correlations and EFA). Further studies conducted in Romania are discussed, both on the correlation with other cognitive ability tests and on the criterion validity of the MAB-II.
THE MANAGEMENT OF INFORMATION AND COMMUNICATION TECHNOLOGY APPLICATION IN TEACHING METHOD INNOVATION IN LOWER SECONDARY SCHOOLS IN BAC NINH CITY, BAC NINH PROVINCE MEETS THE REQUIREMENTS OF THE OVERALL GENERAL EDUCATION PROGRAM - SITUATION AND ISSUES POSED
Authors: Hiển Trần Tiến
Published: November 2020

Innovating teaching methods to meet the requirements of the overall general education program 2018 is an objective inevitable. Managing the application of information and communication technologies (ICTs) in teaching method innovation to meet the requirements of the overall general education program in the current period is the right direction of the lower secondary schools. The author of the article has surveyed 10 lower secondary schools of Bac Ninh city, Bac Ninh province on the current situation of information and communication technology application management in innovation of teaching methods to meet requirements of the overall general education program 2018, the author has assessed the strengths and weaknesses to have positive solutions in the coming time.
The book by S. N. Durylin “In Your Corner”: reciting and interpretation experience
Authors: Korshunova Evgeniia Aleksandrovna
Published: November 2020

This article is first to examine the poetics of the book by S. N. Durylin “In Your Corner” (1924-1942) – the pinnacle of his writing. Comprehensive analysis of poetics of the book genre is conducted. In this context, the book as a genre ensures unity and wholeness of the form and content in dialogical connection of different genre inclusions, sequencing the vibrant cacophony and “polyvocality” of the author's personal projections. Therefore, in namely examination of the genre opens up to the researcher the range of adequate reciting of the book “In Your Corner”, which can be focused not only on the micro-level of an expression (aphorism), but also on the macro-level of the narrative (system of motifs that comprise various recurring themes). The conclusion is made that the figure of the author, who writes his book “for everyone and foe no one”, unites the micro- and macro-levels of narration. This allows viewing problem of the author's “Self” and perceptive mentality in the aspects of dialogueness, substantiated by M. M. Bakhtin. Within the framework of such approach, each layer or level of reciting, is viewed as the “voice” involved in the dialogue alongside the author. Examination of these levels of reciting (philosophical text, the “domestic” text, the level of literary-critical discussion) clarifies the mechanisms of formation of the key mythologem of “your corner” as the authorial model of culture.
“Hadji Abrek” by M. Y. Lermontov: to the question of genesis of the poem and authenticity of the folklore basis
Authors: Alkhlavova Inna Khumkerkhanovna , Khidirova El'mira Sirazhudinovna
Published: November 2020

The subject of this article is the origins of the poem “Hadji Abrek” by M. Y. Lermontov, question of location where the events take place, as well as the question of the possible impact of folk poetic oeuvres upon the work of Mikhail Lermontov. The article describes different opinions and interpretations (within the format of the article) on the topic, to the exclusion of “emphatic” commentaries and remarks. The object of this research is folklore and historical materials that contribute to revelation of idea of the poem, description of the protagonists, characterization of the Caucasian and Dagestan folklore, the echoes of which are traces in Lermontov’s poems.  The authors underline that geographical and ethnographic “nuances” were used by Lermontov to describe the forming picture in the mountain country. The novelty of this study consists in analysis of the material testifying that the inclusion of “installations” of another nation is substantiated in the poem, not just because it is somewhat of a tribute to romanticism, but it is also marks Lermontov’s comprehension of the folklore as an untouchable ”heart” of culture and ethnic uniqueness. The acquired results contribute to the scientific Caucasian studies and Lermontov studies. The conclusion is made of folklore in Lermontov's poem indicates a number of defining characteristics that allowed determining individual expression of poet's work. It is reflected in selection of the examples of folk poetry, peculiar regard to the sources, and their deflection in the poem.
Analysis of procurement of selected agricultural products in Poland in the years 2010-2016
Authors: ROSZKO-WÓJTOWICZ Elżbieta , GRZELAK Maria M.
Published: November 2020

Economic development is characterised by the fact that the share of agriculture tends to decrease both in terms of resources used and domestic product generated. This does not mean, however, that the role of agriculture in the economic development diminishes. It can be considered a paradox that the lower the share of agriculture in the national economy, the greater its role, as it provides raw materials for the production of goods, especially food, which meet the needs of the ever-growing community. The main aim of the presented study is to measure and evaluate changes in agricultural produce procurement in Poland in the years 2010-2016. The following research hypothesis is put forward in the study: Changes in the procurement volume had a much greater impact on the procurement value of selected agricultural produce in Poland in the period considered than changes in the level of transaction prices. In the paper, a comparative analysis of procurement of crop and animal products was conducted. The research process was based primarily on data derived from official statistics obtained from the Central Statistical Office and the Eurostat database regarding procurement of agricultural produce carried out by commercial entities and processing plants. This information is presented in qualitative and quantitative terms for total agriculture, as well as for individual voivodeships.
Prevalência de enteroparasitose em comunidade ribeirinha do estado do Pará, Brasil
Authors: De Sena Luann Wendel Pereira , Pantoja Cintia de Sousa Costa , De Souza Denise Anne Silva , Palheta Suellen Silva Reis , Mello Amanda Gabryelle Nunes Cardoso , Vieira José Luiz Fernandes , Arruda José Eduardo Gomes , Moreira Maria Pantoja
Published: November 2020

Objetivo: Este trabalho tem como objetivo, investigar a prevalência de enteroparasitoses em populações ribeirinhas do estado do Pará, Brasil. Métodos: No período de julho a outubro de 2018, foram coletadas 104 amostras fecais de pessoas de ambos os sexos com idade de 2 a 75 anos e conduzidas ao Laboratório de Análises Clínicas da Escola Superior da Amazônia para análise parasitológica seguindo a metodologia de Hoffman, Pons e Janer. A positividade das amostras foi confirmada pela visualização de formas evolutivas de enteroparasitas. Resultados: Os resultados revelaram positividade em 95,1% dos casos, ressaltando que em 23% eram de poliparasitados. Os helmintos foram os mais frequentes, destacando-se Ascaris lumbricoides (44,23%) e Enterobius vermiculares (13,46%). Entre os protozoários, os mais frequentes foram Entamoeba histolytica/díspar (24,05%), Entamoeba coli (7,69%). Conclusão: Foi encontrado elevado número de casos de parasitismo intestinal na área de estudo, o que recomenda de políticas públicas voltadas à melhoria das condições de saúde das comunidades ribeirinhas.
O impacto do câncer de mama na saúde sexual feminina: uma revisão de literatura
Authors: De Araujo Raysa Maria Silva , Barboza Danielle Laís Lopes , Mass Daniela Winckler , Cavalcante Igor dos Santos , Hasegawa Luciana Eda Maximiano , Silva Martha Laura Leão dos Santos , Veiga Ana Vitória Meireles , Do Nascimento Gabriel Phelipe Dantas , Almendra Thiago Santos Lima , Dos Santos Lúcia Maria de Sousa Aguiar
Published: November 2020

Objetivo: Descrever os efeitos que o câncer de mama exerce na saúde sexual feminina e de que forma ele impacta na qualidade de vida delas, abrangendo aspectos fisiológicos e psicológicos. Métodos: Revisão de Literatura Integrativa, cujos artigos foram buscados nas bases de dados SCIELO, MEDLINE E LILACS. Os critérios de inclusão foram artigos integrais publicados de 2000 a 2020, em português e inglês, e os critérios de exclusão foram artigos não relacionados ao tema. Resultados: A literatura demonstra relação clara e direta dos impactos negativos que o câncer de mama exerce na saúde feminina, evidenciando um quadro de libido reduzida, dispareunia, anorgasmia, ressecamento vaginal e ansiedade ou depressão. A realização da mastectomia representa fator de agravamento, afetando o bem-estar e saúde sexual feminina e causando sequelas na autoimagem corporal. Os resultados obtidos demonstram que a disfunção sexual é um dos principais efeitos negativos, comprometendo a saúde delas, especialmente no pós-cirúrgico. Considerações finais: Conclui-se que o câncer de mama pode prejudicar severamente a sexualidade das pacientes, gerando desfechos de acordo com o tratamento adotado. Por isso, é importante prevenir desfechos negativos e fornecer uma rede de apoio para as mulheres acometidas.
Epidemiology of hereditary diseases in health care: the evolution from theory to technologies and vice versa
Authors: Назаренко Л.П. , Назаренко М.С.
Published: November 2020

В настоящее время наиболее сильное изменение в области эпидемиологии наследственных болезней заключается в переходе от теоретических обобщений популяционной генетики к активному использованию молекулярно-генетических технологий в отношении тестирования отдельных индивидов. Это позволяет персонализировать оказание медицинской помощи, а также генерировать новые знания о грузе наследственных болезней в популяциях с их последующей трансляцией в практику здравоохранения.

At the present time the most dramatic changes in the epidemiology of hereditary diseases is the transition from theoretical principles of population genetics in public health to the active use of molecular genetic technologies for individuals. Genetic discoveries are the basis of individualized medicine, as well as the source of new knowledge about the load of hereditary diseases in populations with their subsequent translation into healthcare system.
Characterization of the genetic heterogeneity of populations through the load of hereditary pathology
Authors: Ельчинова Г.И. , Кадышев В.В. , Зинченко Р.А.
Published: November 2020

На основании архивных данных лаборатории генетической эпидемиологии ФГБНУ «МГНЦ» по 11 российским популяциям предложен метод количественной оценки генетической гетерогенности популяций по грузу аутосомно-доминантной и аутосомно-рецессивной наследственной патологии. Показано, что наименьшей гетерогенностью характеризуется Краснодарский край, наибольшей - население Татарстана.

On the basis of archival data from the laboratory of genetic epidemiology of the RCMG for 11 Russian populations, a method for quantifying the genetic heterogeneity of populations based on the load of autosomal dominant and autosomal recessive hereditary pathology is proposed. It is shown that the Krasnodar region is characterized by the least heterogeneity, and the population of Tatarstan is the largest.
Analysis of the prevalence of rare (orphan) diseases («List 24») and the dynamics of detection of children's patients in the subjects of the Russian Federation
Authors: Комаров И.А. , Красильникова Е.Ю. , Александрова О.Ю. , Зинченко Р.А. , Куцев С.И.
Published: November 2020

Проведен анализ распространенности редких (орфанных) заболеваний («Перечень 24») и динамики выявляемости пациентов детского возраста в 85 регионах РФ в период 2013-2019 гг. Показан ежегодный прирост пациентов в Федеральном регистре (2013 г. - 4962 больных, 2014 г. - 6761, 2015 г. - 7038, 2016 г. - 7625, 2017 г. - 8245, 2018 г. - 8639, 2019 г. - 9088). Динамика доли детей с заболеваниями из «Перечня 24» среди всех больных колебалась в небольших пределах (в среднем 50%). Большинством заболеваний (16 из 24) болеют в основном дети, но они встречаются также у взрослых. Распространенность заболеваний значительно варьировала между субъектами РФ. Улучшение информированности, а также ведение Федерального регистра способствуют эффективной выявляемости и своевременному назначению терапии в детском возрасте. Однако низкие значения распространенности заболеваний, проявляющихся до 1-го года жизни, говорят о сложностях их диагностики и недостаточной выявляемости.

The analysis of the prevalence of rare (orphan) diseases («List of 24») and the dynamics of detection of children’s patients in 85 subjects of the Russian Federation in the period 2013-2019 showed an annual increase in patients in the Federal register (2013 - 4962 patients, 2014 - 6761, 2015 - 7038, 2016 - 7625, 2017 - 8245, 2018 - 8639, 2019 - 9088). The dynamics of the share of children with diseases from the “List of 24” among all patients fluctuated within small limits (on average 50%). Most of the diseases (16 out of 24) are mostly between children, but they also occur in adults. The prevalence of diseases varied significantly between the subjects of the Russian Federation. Improving awareness, as well as maintaining a Federal register promote effective detection and timely treatment in children. However, the low prevalence of diseases that occur before the 1st year of life indicates the complexity of their diagnosis and lack of detection.
Analysis of the mutational spectrum of the SLC26A4 gene and its contribution to the etiology of inherited hearing loss in the indigenous population of Southern Siberia
Authors: Данильченко В.Ю. , Зыцарь М.В. , Маслова Е.А. , Бады-Хоо М.С. , Морозов И.В. , Бондарь А.А. , Посух О.Л.
Published: November 2020

Мутации в гене SLC26A4 являются частой причиной потери слуха во многих регионах мира. В работе приводятся результаты молекулярно-генетического анализа (с использованием секвенирования по Сэнгеру) последовательности гена SLC26A4, впервые проведенного в выборке пациентов с потерей слуха неустановленной этиологии (n=232) из Республик Тыва и Алтай. Установлены контрастные различия патогенетического вклада мутаций в гене SLC26A4 в этиологию нарушения слуха у коренных жителей этих географически близких регионов: 28,2% - для тувинцев и 4,3% - для алтайцев. Выявлены как уже известные, так и новые патогенные варианты, а также широкий спектр полиморфных вариантов гена SLC26A4.

Mutations in the SLC26A4 gene are a common cause of hearing loss in many regions of the world. This paper presents the results of molecular genetic analysis (by Sanger sequencing) of the SLC26A4 sequence, first performed in the sample of patients with hearing loss of unknown etiology (n=232) from the Tyva Republic and the Altai Republic. Contrast differences of the pathogenic contribution of SLC26A4 mutations to the etiology of hearing impairment were revealed in the indigenous peoples of these geographically close regions: 28.2% for Tuvinians and 4.3% for Altaians. Both known and novel pathogenic variants as well as a wide range of polymorphic variants were found in the SLC26A4 gene sequence.
Population Genomics of Russian populations
Authors: Степанов В.А.
Published: November 2020

Популяционная геномика человека является мощным современным подходом в популяционной генетике, базирующемся на технологиях геномного секвенирования, биоинформатики и анализа больших данных. Геномный анализ генетической вариабельности в популяциях является фундаментальной основой генетики болезней и разработки путей их диагностики, терапии и профилактики. В работе представлены собственные данные о геномном анализе генетического разнообразия населения России. Показано, что генофонд современных народов России формировался на протяжении многих тысяч лет в ходе совокупного влияния миграций, изоляции расстоянием, эффектов основателя и естественного отбора. Сформировавшиеся в ходе микроэволюции геномные паттерны современных популяций в существенной мере определяют композицию генетических факторов как частых хронических, так и редких моногенных заболеваний.

Human population genomics is a powerful modern approach in population genetics based on technologies of genomic sequencing, bioinformatics, and big data analysis. Genomic analysis of genetic variability in populations is a fundamental basis for the genetics of diseases and the development of ways for their diagnosis, therapy and prevention. The work presents the own data on the genomic analysis of the genetic diversity of the Russian populations. It is shown that the gene pool of modern populations of Russia was formed over many thousands of years by the combined effects of migrations, isolation by distance, founder effects and natural selection. The genomic patterns of modern populations formed during microevolution substantially determine the composition of genetic factors of both frequent chronic and rare monogenic diseases.