bluuebunny/crossref_metadata_2025 huggingface dataset:
Localisation of Dirac modes in gauge theories and Goldstone’s theorem at finite temperature
Authors: Giordano Matteo
Published: December 2022

Abstract

I discuss the possible effects of a finite density of localised near-zero Dirac modes in the chiral limit of gauge theories with Nf degenerate fermions. I focus in particular on the fate of the massless quasi-particle excitations predicted by the finite-temperature version of Goldstone’s theorem, for which I provide an alternative and generalised proof based on a Euclidean SU(Nf )A Ward-Takahashi identity. I show that localised near-zero modes can lead to a divergent pseudoscalar-pseudoscalar correlator that modifies this identity in the chiral limit. As a consequence, massless quasi-particle excitations can disappear from the spectrum of the theory in spite of a non-zero chiral condensate. Three different scenarios are possible, depending on the detailed behaviour in the chiral limit of the ratio of the mobility edge and the fermion mass, which I prove to be a renormalisation-group invariant quantity.
Partial compositeness under precision scrutiny
Authors: Cai Haiying , Cacciapaglia Giacomo
Published: December 2022

Abstract

We revisit the impact of top partial compositeness on electroweak precision observables in the misaligned vacuum basis. We identify a new source for S in the singlet mixing case, and for S-T in the bi-doublet mixing, stemming from misalignment in the gauge couplings of the top partners. Hence, a positive shift in T can be obtained in both cases, as preferred by the recent CDF measurement of the W mass. These results, obtained for the minimal fundamental coset SU(4)/Sp(4), apply to any composite Higgs model with top partial compositeness.
Dynamical evolution in the D1D5 CFT
Authors: Guo Bin , Mathur Samir D.
Published: December 2022

Abstract

It is interesting to ask: how does the radial space direction emerge from the CFT in gauge-gravity duality? In this context we resolve a long-standing puzzle with the gravity duals of two classes of states in the D1D5 CFT. For each class the CFT states are in the untwisted sector, suggesting that the energy gap should be 1/Ry where Ry is the radius of the circle on which the D1D5 CFT is compactified. For one class of states, the gravity dual indeed has exactly this gap, while for the other class, the gravity dual has a very deep throat, leading to an energy gap much smaller than 1/Ry. We resolve this puzzle by showing that for the latter class of states, perturbing the CFT off its free point leads to the formation of a band structure in the CFT. We also explain why such a band structure does not arise for the first class of states. Thus for the case where a deep throat emerges in the gravity description, the dynamics of falling down this throat is described in the CFT as a sequential ‘hopping’ between states all of which have the same energy at the free point; this hopping amplitude converts an integer spaced spectrum into a closely spaced band of energy levels.
Quantum interference in gravitational particle production
Authors: Basso Edward , Chung Daniel J. H. , Kolb Edward W. , Long Andrew J.
Published: December 2022

Abstract

Previous numerical investigations of gravitational particle production during the coherent oscillation period of inflation displayed unexplained fluctuations in the spectral density of the produced particles. We argue that these features are due to the quantum interference of the coherent scattering reactions that produce the particles. We provide accurate analytic formulae to compute the particle production amplitude for a conformally- coupled scalar field, including the interference effect in the kinematic region where the production can be interpreted as inflaton scattering into scalar final states via graviton exchange.
Fixed point theorems and periodic problems for nonlinear Hill’s equation
Authors: Nowakowski A. , Plebaniak R.
Published: December 2022

Two main results of fixed point theory in infinite dimensional space are Schauder’s theorem and the contraction mapping principle. Krasnoselskii combined them into one fixed point result. In this paper, we continue the study of extensions of these theorems investigating a convex modular in a original vector space, not in modular space and without $$\Delta _{2}$$

Δ
2

condition, to provide certain extensions of Banach contraction principle and Krasnoselskii fixed point theorem. We applied that theorem to solve the nonlinear periodic problem of Hill’s equation.
Development of a conceptual framework for a new patient-reported outcome measure for pain in women following mesh surgery for pelvic floor disorders: a qualitative study
Authors: Ralphsmith Maisie , Ahern Susannah , Dean Joanne , O’Connell Helen E. , Ruseckaite Rasa
Published: December 2022

Introduction and hypothesis

The Australasian Pelvic Floor Procedure Registry (APFPR) collects both clinical and health-related quality of life (HRQoL) data on women undergoing surgery using a prosthesis such as mesh for pelvic organ prolapse (POP) and stress urinary incontinence (SUI). The registry lacks a suitable instrument to assess pain in women following mesh surgery for SUI and POP. This qualitative study describes the views on pain following mesh surgery in women and clinicians through the development of a conceptual framework, which may inform the development of a new instrument for the APFPR.

Methods

We conducted semi-structured interviews with women following mesh surgery for POP and SUI (n=17) and clinicians (n=6) in Victoria, Australia. We sought to reveal aspects of any sort of pain after a pelvic floor procedure. Interviews covered sensation, region, continuity of pain, triggers, and the mode and method of administration for a new pain-specific patient-reported outcome measure. Data were analysed using thematic analysis.

Results

We identified the important components of pain felt by women with POP and SUI after surgery using mesh. From the seven themes outlined, a conceptual framework was developed compiling related components of pain into six specific domains.

Conclusions

This study identifies the important components of pain felt by women following mesh surgery. It is hoped that the development of a pain-specific PROM, as supported by clinicians, will assist in the timely and appropriate diagnosis and management of POP and SUI.
A rationale for considering heart/brain axis control in neuropsychiatric disease
Authors: Garrett Lillian , Trümbach Dietrich , Spielmann Nadine , Wurst Wolfgang , Fuchs Helmut , Gailus-Durner Valerie , Hrabě de Angelis Martin , Hölter Sabine M.
Published: December 2022

Neuropsychiatric diseases (NPD) represent a significant global disease burden necessitating innovative approaches to pathogenic understanding, biomarker identification and therapeutic strategy. Emerging evidence implicates heart/brain axis malfunction in NPD etiology, particularly via the autonomic nervous system (ANS) and brain central autonomic network (CAN) interaction. This heart/brain inter-relationship harbors potentially novel NPD diagnosis and treatment avenues. Nevertheless, the lack of multidisciplinary clinical approaches as well as a limited appreciation of molecular underpinnings has stymied progress. Large-scale preclinical multi-systemic functional data can therefore provide supplementary insight into CAN and ANS interaction. We here present an overview of the heart/brain axis in NPD and establish a unique rationale for utilizing a preclinical cardiovascular disease risk gene set to glean insights into heart/brain axis control in NPD. With a top-down approach focusing on genes influencing electrocardiogram ANS function, we combined hierarchical clustering of corresponding regional CAN expression data and functional enrichment analysis to reveal known and novel molecular insights into CAN and NPD. Through ‘support vector machine’ inquiries for classification and literature validation, we further pinpointed the top 32 genes highly expressed in CAN brain structures altering both heart rate/heart rate variability (HRV) and behavior. Our observations underscore the potential of HRV/hyperactivity behavior as endophenotypes for multimodal disease biomarker identification to index aberrant executive brain functioning with relevance for NPD. This work heralds the potential of large-scale preclinical functional genetic data for understanding CAN/ANS control and introduces a stepwise design leveraging preclinical data to unearth novel heart/brain axis control genes in NPD.
Breast cancer: emerging principles of metastasis, adjuvant and neoadjuvant treatment from cancer registry data
Authors: Engel Jutta , Eckel Renate , Halfter Kathrin , Schubert-Fritschle Gabriele , Hölzel Dieter
Published: December 2022

Purpose

Growing primary breast cancers (PT) can initiate local recurrences (LR), regional lymph nodes (pLN) and distant metastases (MET). Components of these progressions are initiation, frequency, growth duration, and survival. These characteristics describe principles which proposed molecular concepts and hypotheses must align with.

Methods

In a population-based retrospective modeling approach using data from the Munich Cancer Registry key steps and factors associated with metastasis were identified and quantified. Analysis of 66.800 patient datasets over four time periods since 1978, reliable evidence is obtained even in small subgroups. Together with results of clinical trials on prevention and adjuvant treatment (AT) principles for the MET process and AT are derived.

Results

The median growth periods for PT/MET/LR/pLN comes to 12.5/8.8/5/3.5 years, respectively. Even if 30% of METs only appear after 10 years, a pre-diagnosis MET initiation principle not a delayed one should be true. The growth times of PTs and METs vary by a factor of 10 or more but their ratio is robust at about 1.4. Principles of AT are 50% PT eradication, the selective and partial eradication of bone and lung METs. This cannot be improved by extending the duration of the previously known ATs.

Conclusion

A paradigm of ten principles for the MET process and ATs is derived from real world data and clinical trials indicates that there is no rationale for the long-term application of endocrine ATs, risk of PTs by hormone replacement therapies, or cascading initiation of METs. The principles show limits and opportunities for innovation also through alternative interpretations of well-known studies. The outlined MET process should be generalizable to all solid tumors.
Enhancement of cytotoxic and antioxidant activities of Digenea simplex chloroform extract using the nanosuspension technique
Authors: El-Rafie Hanaa M. , Hasan Enas A. , Zahran Magdy K.
Published: December 2022

Digenea simplex (D. simplex), an Egyptian marine red macroalga, contains a diverse group of phytochemicals with unique bioactivities. At the same time, the synthesis of nanosuspension (NS) has received increasing interest to optimize the technological aspects of drugs. Thence, the main objective of this work was to use the chloroform extract (ChlE) of D. simplex to prepare its nanosuspension (ChlE-NS) formulation to increase its aqueous solubility, thereby improving its bioactivity. By using FTIR, GC/MS analysis, and phytochemical screening assays, the chemical profiling of ChlE was assessed. NS was prepared by the antisolvent precipitation technique using 1.5% w/v polyvinyl alcohol (PVA). A light microscope, FTIR, particle size distribution, polydispersity index (PDI), and zeta potential (ZP) measurements was used to characterize the prepared NS. Four cancer cell lines were used in the MTT experiment to investigate the anticancer potential of ChlE and ChlE-NS. An apoptotic mechanism was established using acridine orange/ethidium bromide (AO/EB) dual staining, DNA fragmentation, and increased caspase activity. ChlE and ChlE-NS were also evaluated as antioxidants using DPPH and ABTS free radical assays. The results showed that, when compared to ChlE, ChlE-NS had greater cytotoxic activity against the four cancer cell lines. However, results of antioxidant activity showed that ChlE-NS had an IC50 of 36.86 ± 0.09 and 63.5 ± 0.47%, while ChlE had values of 39.90 ± 0.08 and 86.5 ± 0.8% in DPPH and ABTS assays, respectively. Based on the results of this research, D. simplex ChlE-NS may be an effective strategy for enhancing ChlE's cytotoxic and antioxidant activities.

Graphical abstract
Kidney concentrating capacity in children with autosomal recessive polycystic kidney disease is linked to glomerular filtration and hypertension
Authors: Seeman Tomáš , Bláhová Kveta , Fencl Filip , Klaus Richard , Lange-Sperandio Bärbel , Hrčková Gabriela , Podracká Ĺudmila
Published: December 2022

Background

Impaired kidney concentration capacity is present in half of the patients with autosomal dominant polycystic kidney disease (ADPKD). The kidney concentrating capacity was further impaired within the animal model of autosomal recessive polycystic kidney disease (ARPKD). To date, only one small study has investigated it in children having ARPKD. Therefore, we aimed to study the kidney concentrating ability in a larger cohort of children with ARPKD.

Methods

Eighteen children (median age 8.5 years, range 1.3–16.8) were retrospectively investigated. A standardized kidney concentrating capacity test was performed after the application of a nasal drop of desmopressin (urine osmolality > 900 mOsmol/kg). The glomerular filtration rate was estimated using the Schwartz formula (eGFR) and blood pressure (BP) was measured as office BP.

Results

Kidney concentrating capacity was decreased (urine osmolality < 900 mOsmol/kg) in 100% of children with ARPKD. The median urine osmolality after desmopressin application was 389 (range 235–601) mOsmol/kg. Sixteen patients (89%) were defined as hypertensive based on their actual BP level or their use of antihypertensive drugs. The maximum amounts of urinary concentration correlated significantly with eGFR (r = 0.72,p < 0.0001) and hypertensive scores (r = 0.50,p < 0.05), but not with kidney size. Twelve patients (67%) were defined as having CKD stages 2–4. The median concentrating capacity was significantly lower in children within this group, when compared to children with CKD stage 1 possessing a normal eGFR (544 mOsmol/kg, range 413–600 mOsmol/kg vs. 327 mOsmol/kg, range 235–417 mOsmol/l,p < 0.001).

Conclusions

Impaired kidney concentrating capacity is present in most children with ARPKD and is associated with decreased eGFR and hypertension.

Graphical abstract
The role of invasive alien species in the emergence and spread of zoonoses
Authors: Roy Helen E. , Tricarico Elena , Hassall Richard , Johns Charlotte A. , Roy Katy A. , Scalera Riccardo , Smith Kevin G. , Purse Bethan V.
Published: December 2022

The role of invasive alien species in the transmission dynamics of zoonotic pathogens is often overlooked, despite the rapid escalation in biological invasions globally. Here we synthesise available information on the influence of invasive alien species on zoonotic pathogen dynamics in invaded ranges, focussing on Europe, and identify key associated knowledge gaps. We identified 272 documented interactions between alien species and zoonotic pathogens within invaded ranges. The majority of these involved invasive alien mammals followed by birds with only a few occurrences of other taxa documented. A wide range of potential interactions between invasive alien species and zoonotic pathogens were identified but few studies considered transmission to humans and so there was limited evidence of actual impacts on human health. However, there is an urgent need to raise awareness of the potential risks posed to human health by the transmission of zoonotic diseases by invasive alien species; the role of invasive alien species in zoonotic disease transmission may exceed that of native wildlife and occur in a relatively short period following the arrival of an invasive alien species within a new region. Ecological and social mechanisms govern the dynamics of zoonotic disease transmission but wildlife diseases are not consistently included within animal, plant and human policies. Rapid advances in the development of systems frameworks that integrate the ecological, economic and social processes promoting spillover in rapidly changing environments will increase understanding to inform decision-making.
Improving the efficiency of multi-location field trials with complete and incomplete relationship information
Authors: Michel Sebastian , Löschenberger Franziska , Ametz Christian , Bürstmayr Hermann
Published: December 2022

The increasingly cost-efficient availability of ‘omics’ data has led to the development of a rich framework for predicting the performance of non-phenotyped selection candidates in recent years. The improvement of phenotypic analyses by using pedigree and/or genomic relationship data has however received much less attention, albeit it has shown large potential for increasing the efficiency of early generation yield trials in some breeding programs. The aim of this study was accordingly to assess the possibility to enhance phenotypic analyses of multi-location field trials with complete relationship information as well as when merely incomplete pedigree and/or genomic relationship information is available for a set of selection candidates. For his purpose, four winter bread wheat trial series conducted in Eastern and Western Europe were used to determine the experimental efficiency and accuracy of different resource allocations with a varying degree of relationship information. The results showed that modelling relationship between the selection candidates in the analyses of multi-location trial series was up to 20% more efficient than employing routine analyses, where genotypes are assumed to be unrelated. The observed decrease in efficiency and accuracy when reducing the testing capacities was furthermore less pronounced when modelling relationship information, even in cases when merely partial pedigree and/or genomic information was available for the phenotypic analyses. Exploiting complete and incomplete relationship information in both preliminary yield trials and multi-location trial series has thus large potential to optimize resource allocations and increase the selection gain in programs that make use of various predictive breeding methods.
Parents’ Perceptions: Environments and the Contextual Strategies of Parents to Support the Participation of Children and Adolescents with Autism Spectrum Disorder—A Descriptive Population-Based Study from Switzerland
Authors: Krieger Beate , Moser Albine , Morgenthaler Thomas , Beurskens Anna J. H. M. , Piškur Barbara
Published: December 2022

Environments have a modifying effect on the participation of children and adolescents with autism spectrum disorder (ASD) in all areas of life. This cross-sectional study investigated parental perspectives on supportive or hindering environments and the daily contextual strategies parents used to enhance their children’s participation. Qualitative and quantitative data gathered from 115 parents from German-speaking Switzerland using the participation and environment measure-child and youth (PEM-CY) were analyzed. Results revealed 45 environmental supports and barriers at home, at school, and in the community. Contextual strategies were identified in combination with people, activities, time, objects, and places. Parental perspectives on participation and their contextual strategies should be considered in environmental-based interventions to support the participation of children and adolescents with ASD.
Evaluating universal design of built environments: an empirical study of stakeholder practice and perceptions
Authors: Watchorn Valerie , Hitch Danielle , Tucker Richard , Frawley Patsie , Aedy Kathryn , Grant Cathryn
Published: December 2022

Universal design aims to reduce environmental barriers and enhance usability of buildings for all people, particularly those with disabilities. There are known challenges relating to the evaluation of universal design and evidence supporting this concept is limited. This study aimed to gather information on current practice and what stakeholders perceive as important to universal design evaluation. A mixed methods approach was employed, and data were collected via online survey (n = 157) and semi-structured interviews (n = 37). Participants included industry professionals, policy makers, government officials, academics, and people with disabilities. Just over one-third of participants stated that they had experience of evaluating universal design in public built environments. Checklists were most commonly used, yet participants expressed concern with their suitability for this purpose. Almost all participants perceived evaluation of universal design as important, citing its value to advocacy, professional development and strengthening the evidence base of universal design. Findings from this study highlight a tension between a desire for efficiency and consistency, as offered by a checklist approach, and the adoption of a holistic and multidisciplinary method of evaluation that encompasses the complexity of universal design application.
Between Cereal Agriculture and Animal Husbandry: Millet in the Early Economy of the North Pontic Region
Authors: Dal Corso Marta , Pashkevych Galyna , Filipović Dragana , Liu Xinyi , Motuzaite Matuzeviciute Giedre , Stobbe Astrid , Shatilo Ludmila , Videiko Mihail , Kirleis Wiebke
Published: December 2022

Broomcorn millet (Panicum miliaceumL.) was first domesticated in China and dispersed westward via Central Asia in the 3rd millennium BC, reaching Europe in the 2nd millennium BC. North of the Black Sea, the North Pontic steppe and forest-steppe areas are key regions for understanding the westward dispersal of millet, as evidenced by the earliest direct radiocarbon dates on European millet grains, which we present here. Examining various lines of evidence relevant to crop cultivation, animal husbandry, contacts and lifestyles, we explore the regional dynamics of the adoption of millet, broadening knowledge about past subsistence strategies related to the ‘millet farmers/consumers’ who inhabited the northern Black Sea region during the Bronze and Iron Ages. Our re-evaluation of crop evidence contributes to ongoing discussions on the mobility of prehistoric communities in the Eurasian steppe and forest-steppe—for instance, on whether millet was linked to full-time mobile pastoralists, who occasionally grew or only consumed it, or whether it was linked to sedentary farmers and cattle herders who regularly cultivated millet, among other crops. From the Bronze Age to the Late Antique, this crop is attested under different socio-cultural conditions that suggest it was adaptable to stockbreeding and the natural environment and consumed since the mid 2nd millennium BC in the northern Black Sea region.
Detecting and locating trending places using multimodal social network data
Authors: Lucas Luis , Tomás David , Garcia-Rodriguez Jose
Published: December 2022

This paper presents a machine learning-based classifier for detecting points of interest through the combined use of images and text from social networks. This model exploits the transfer learning capabilities of the neural network architecture CLIP (Contrastive Language-Image Pre-Training) in multimodal environments using image and text. Different methodologies based on multimodal information are explored for the geolocation of the places detected. To this end, pre-trained neural network models are used for the classification of images and their associated texts. The result is a system that allows creating new synergies between images and texts in order to detect and geolocate trending places that has not been previously tagged by any other means, providing potentially relevant information for tasks such as cataloging specific types of places in a city for the tourism industry. The experiments carried out reveal that, in general, textual information is more accurate and relevant than visual cues in this multimodal setting.
Expression of juvenility related microRNAs and target genes during micropropagation of silver birch (Betula pendula Roth.)
Authors: Krivmane Baiba , Girgžde Elva , Samsone Ineta , Ruņģis Dainis
Published: December 2022

Silver birch (Betula pendulaRoth.) is an ecologically and economically important deciduous tree species in Northern Europe. In vitro culture initiation and shoot rejuvenation from birches in their reproductive phase is difficult and often unsuccessful. Currently, markers to evaluate the degree of juvenility of birch in vitro shoots, which could be used to track the rejuvenation process and to determine factors affecting it, have not been developed. The aims of this study were to assess expression of juvenility related microRNAs and target genes during micropropagation of silver birch, and to investigate factors affecting juvenility of birch genotypes with different in vitro morphogenic ability. Potential precursor sequences and target genes of the microRNAs miR156 and miR172 were determined by alignment to the birch unigene set. Ten potential miR156 and miR172 precursor sequences were identified, and were tested for the ability to form the required stem-loop structure. Based on precursor sequences, primers were designed for real time PCR analysis of precursor miRNA expression. Expression patterns of two miR156 family precursors (miR156_511 and miR156_789) and one miR172 precursor (miR172_1931) and two target genes (BpSPL1andBpAP2) had the best correlation with juvenility/maturity in the analysed in vitro propagated silver birch samples. Expression patterns of these miRNA precursors and target genes were also investigated in samples cultured under different in vitro conditions. This study provides an initial survey of molecular markers for assessment of phase change in birch in vitro micropropagation.
Identification of key genes of anti-programmed death ligand 1 for meningioma immunotherapy by bioinformatic analysis
Authors: Zhang Lijian , Wang Luxuan , Tan Yanli , Li Chunhui , Fang Chuan
Published: December 2022

Meningioma is one of the most common primary tumors in the central nervous system (CNS). A deeper understanding of its molecular characterization could provide potential therapeutic targets to reduce recurrence. In this study, we attempted to identify specific gene mutations in meningioma for immunotherapy. One GSE43290 dataset was obtained from the Gene Expression Omnibus (GEO) database to find differentially expressed genes (DEGs) between meningioma tissues and normal meninges. In total, 420 DEGs were identified, including 15 up-regulated and 405 down-regulated genes. Functional enrichment analysis showed that these DEGs were mainly enriched in PI3K-Akt signaling pathway, Focal adhesion, and MAPK signaling pathway. We identified 20 hub genes by protein–protein interaction (PPI) analysis. Among the hub genes, the expression of FLT1, CXCL8, JUN, THBS1, FECAM1, CD34, and FGF13 were negatively correlated with Programmed Death Ligand-1 (PD-L1). Additionally, the expression of those genes was co-regulated by miR‐155‐5p. The findings suggest that miR-155-5p play an important role in the pathogenesis of meningioma and may represent potential therapeutic targets for its anti-PD-L1 immunotherapy.
Superior Fidelity and Distinct Editing Outcomes of SaCas9 Compared with SpCas9 in Genome Editing
Authors: Yang Zhi-Xue , Fu Ya-Wen , Zhao Juan-Juan , Zhang Feng , Li Si-Ang , Zhao Mei , Wen Wei , Zhang Lei , Cheng Tao , Zhang Jian-Ping , Zhang Xiao-Bing
Published: December 2022

A series of clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (Cas9) systems have been engineered for genome editing. The most widely used Cas9 is SpCas9 from Streptococcus pyogenes and SaCas9 from Staphylococcus aureus. However, a comparison of their detailed gene editing outcomes is still lacking. By characterizing the editing outcomes of 11 sites in human induced pluripotent stem cells (iPSCs) and K562 cells, we found that SaCas9 could edit the genome with greater efficiencies than SpCas9. We also compared the effects of spacer lengths of single-guide RNAs (sgRNAs; 18–21 nt for SpCas9 and 19–23 nt for SaCas9) and found that the optimal spacer lengths were 20 nt and 21 nt for SpCas9 and SaCas9, respectively. However, the optimal spacer length for a particular sgRNA was 18–21 nt for SpCas9 and 21–22 nt for SaCas9. Furthermore, SpCas9 exhibited a more substantial bias than SaCas9 for nonhomologous end–joining (NHEJ) +1 insertion at the fourth nucleotide upstream of the protospacer adjacent motif (PAM), indicating a characteristic of a staggered cut. Accordingly, editing with SaCas9 led to higher efficiencies of NHEJ-mediated double-stranded oligodeoxynucleotide (dsODN) insertion or homology-directed repair (HDR)-mediated adeno-associated virus serotype 6 (AAV6) donor knock-in. Finally, GUIDE-seq analysis revealed that SaCas9 exhibited significantly reduced off-target effects compared with SpCas9. Our work indicates the superior performance of SaCas9 to SpCas9 in transgene integration-based therapeutic gene editing and the necessity to identify the optimal spacer length to achieve desired editing results.
Macaulay and the Enlightenment
Authors: Wolloch Nathaniel
Published: December 2022

A new intellectual biography of Thomas Babington Macaulay, showing how nineteenth-century British liberal culture retained and transformed the ideas of the Enlightenment in a rapidly changing world.
TikTok as a Learning Tool for Archaeology
Authors: Khan Yuhana
Published: December 2022

Overview

Since its launch, TikTok has become one of the world's most popular social media apps. Once primarily used by teenagers, this app is now used by people of all ages; this shift is largely attributable to the COVID-19 pandemic, when many people transitioned to engaging with others via social media instead of having in-person interactions. Now, anyone who has either the app or access to a web browser can view a plethora of videos, all 10 minutes and under, on any topic. Informational videos about archaeology may not be promoted on everyone's personalized home page—called the For You page (FYP)—but they are easily accessible through the search function. This review will discuss the impact TikTok has on the world of archaeology, with a focus on public engagement, museums, and especially teaching and learning. The social power of this app needs to be acknowledged. Archaeology can introduce the public to snapshots of daily life from the past, a task that fits well with the design of TikTok. This social platform can become a resource to create spaces to learn more, especially through interactive conversations such as in the comments section or response videos.
Two-way wave–vortex interactions in a Lagrangian-mean shallow water model
Authors: Maitland-Davies Cai , Bühler Oliver
Published: December 2022

We derive and investigate numerically a reduced model for wave–vortex interactions involving non-dispersive waves, which we study in a two-dimensional shallow water system with an eye towards applications in atmosphere–ocean fluid dynamics. The model consists of a coupled set of nonlinear partial differential equations for the Lagrangian-mean velocity and the wave-related pseudomomentum vector field defined in generalized Lagrangian-mean theory. It allows for two-way interactions between the waves and the balanced flow that is controlled by the distribution of Lagrangian-mean potential vorticity, and for strong solutions it features a desirable exact energy conservation law for the sum of wave energy and mean flow energy. Our model goes beyond standard ray tracing as we can derive weak solutions that contain discontinuities in the pseudomomentum field, using the theory of weakly hyperbolic systems. This allows caustics to form without predicting infinite wave amplitudes, as would be the case in the standard ray-tracing theory. Suitable wave forcing and dissipation terms are added to the model and a numerical scheme for the model is implemented as a coupled set of pseudo-spectral and finite-volume integrators. Idealized examples of interactions between wavepackets and simple vortex structures are presented to illustrate the model dynamics. The unforced and non-dissipative simulations suggest a heuristic rule of ‘greedy’ waves, i.e. in the long run the wave field always extracts energy from the mean flow.
Dispersion of finite-size, non-spherical particles by waves and currents
Authors: Clark Laura K. , DiBenedetto Michelle H. , Ouellette Nicholas T. , Koseff Jeffrey R.
Published: December 2022

We present the results of a set of experiments designed to measure the dispersion of non-spherical particles in a wave–current flow. We released negatively buoyant discs, rods and unit-aspect-ratio cylinders into a flow both with and without waves and analysed their respective landing positions to quantify how much they had dispersed while in the flow. We found that the presence of waves significantly increased the dispersion of the particles, and that the magnitude of this increase depends on particle shape and volume. In particular, thinner rods and thinner discs have greater relative dispersion than thicker rods and thicker discs, respectively, and smaller particles have greater relative dispersion than larger particles. Although the particles travelled farther in the presence of waves, the increase in dispersion was much greater than could be explained solely by increased transport distance. These results indicate that models of microplastic transport must account for waves as well as particle characteristics.
A TWELVE-HUNDRED-YEAR STABLE OXYGEN ISOTOPE CHRONOLOGY CONSTRUCTED USING SUBFOSSIL WOOD FROM SCHWARZENSEE LAKE, AUSTRIAN ALPS
Authors: Kłusek Marzena , Grabner Michael , Pawlyta Jacek , Pawełczyk Sławomira
Published: December 2022

This study presents a new stable oxygen isotope chronology, covering the years 800–2000 AD, constructed using modern and subfossil wood derived from trees growing around Lake Schwarzensee in Austria. The climatic signal imparted in the chronology is conditioned mainly by the direct influence of environmental factors on the isotopic signature of source water, which in turn is regulated by evaporation and condensation mechanisms. The second driver of stable oxygen isotope is the physiological response of trees to changing weather conditions, most importantly rates of transpiration. The chronology of stable oxygen isotopes corresponds well with both temperature (r = 0.485; p < 0.05) and total precipitation (r = −0.548; p < 0.05) during the growing season (May–September). This mixed signal results from the fact that the relationship between the content of stable oxygen isotopes and the influence of climate is multifactorial. Moreover, the effect exerted by meteorological conditions on stable isotope ratio changes over time. This is most probably linked to interannual variation in climatic and environmental factors.
Risk and Preferences for Government Healthcare Spending: Evidence from the UK COVID-19 Crisis
Authors: Blumenau Jack , Hicks Timothy , Pahontu Raluca L.
Published: December 2022

The onset of the COVID-19 pandemic constituted a large shock to the risk of acquiring a disease that represents a meaningful threat to health. We investigate whether individuals subject to larger increases in objective health risk – operationalized by occupation-based measures of proximity to other people – became more supportive of increased government healthcare spending during the crisis. Using panel data that track UK individuals before (May 2018–December 2019) and after (June 2020) the outbreak of the pandemic, we implement a fixed-effect design that was pre-registered before the key treatment variable was available to us. While individuals in high-risk occupations were more worried about their personal risk of infection and had higher COVID-19 death rates, there is no evidence that increased health risks during COVID-19 shifted either attitudes on government spending on healthcare or broader attitudes relating to redistribution. Our findings are consistent with recent research demonstrating the limited effects of the pandemic on political attitudes.
Updating the distribution range of the maned wolf Chrysocyon brachyurus in Argentina
Authors: Orozco M. Marcela , Caruso Nicolás , Natalini M. Belén , Iaconis Karina , Tittarelli Marcela , Juarez Cecilia P. , Pautasso Andrés , Rosacher Conrado , Gonzalez Ciccia Paula , Soler Lucía
Published: December 2022

The maned wolf Chrysocyon brachyurus, the fourth largest canid, is categorized as Near Threatened on the IUCN Red List. The objectives of this study were to update information on the occurrence of this species in Argentina, compare the current distribution to that previously described for 1988–2008, and indicate the areas in which the species is exposed to particular hazards. We created a database that included 1,051 new records of C. brachyurus for 2009-2021, in addition to records for 1988–2008 that had not been reported previously. We calculated the area of occupancy of the species in Argentina to be 500,000 km2. Most of the new records of C. brachyurus are in the Chaco Seco, Espinal and Pampas ecoregions. Our findings indicate a current area of occupancy 61% higher than that calculated from records for 1988–2008. However the location and frequency of reported threats and the intense environmental transformation that characterizes the areas for which we obtained new records suggest counterintuitive implications for the conservation of the species because of increased human–wildlife interactions. Our study reveals the need for systematic research to improve the understanding of the ecological processes that affect the maned wolf in Argentina, and will aid in the development of conservation strategies for the species.
On Duverger and “Laws of Politics”
Authors: Cuzán Alfred G.
Published: December 2022

In “In Laws of Politics and How to Establish Them,” Erik Weber contends that my arguments for the existence of “five laws of politics” are “inconclusive.” Although the “empirical evidence is impressive,” he avers, the “underlying social mechanisms” responsible for the adduced relationships are missing. Without it, he adds, no empirical relationship rises to the special status of a “law” of politics. Helpfully, Weber did not stop there. Using the example of Duverger’s laws, he suggested ways to close the “argumentative gap.” In this article, I aim to do just that.
Links between early-life contextual factors and later-life cognition and the role of educational attainment
Authors: Palms Jordan D. , Zaheed Afsara B. , Morris Emily P. , Martino Alexa , Meister Lindsey , Sol Ketlyne , Zahodne Laura B.
Published: December 2022

Objective:

Educational attainment is a well-documented predictor of later-life cognition, but less is known about upstream contextual factors. This study aimed to identify which early-life contextual factors uniquely predict later-life global cognition and whether educational attainment mediates these relationships.

Method:

Participants were drawn from the Michigan Cognitive Aging Project (N = 485; Mage = 63.51; SDage = 3.13; 50% non-Hispanic Black). Early-life exposures included U.S. region of elementary school (Midwest, South, Northeast), average parental education, household composition (number of adults (1, 2, 3+), number of children), school racial demographics (predominantly White, predominantly Black, diverse), self-reported educational quality, and school type (public/private). Later-life global cognition was operationalized with a factor score derived from a comprehensive neuropsychological battery. Sequential mediation models controlling for sociodemographics estimated total, direct, and indirect effects of early-life contextual factors on cognition through educational attainment (years).

Results:

Higher educational quality, higher parental education, and attending a private school were each associated with better cognition; attending a predominantly Black or diverse school and reporting three or more adults in the household were associated with lower cognition. After accounting for educational attainment, associations remained for educational quality, school type, and reporting three or more adults in the household. Indirect effects through educational attainment were observed for school region, educational quality, school racial demographics, and parental education.

Conclusions:

School factors appear to consistently predict later-life cognition more than household factors, highlighting the potential long-term benefits of school-level interventions for cognitive aging. Future research should consider additional mediators beyond educational attainment such as neighborhood resources and childhood adversity.
Ionospheric Oscillations With a Quasi‐Period of ∼6 hr During Intense Magnetic Storms
Authors: Huang Chao‐Song , Zhang Yongliang , Wang Wenbin , Wu Qian , Lin Dong , Qian Liying
Published: December 2022

We study the variations of the topside ionospheric ion density measured by Defense Meteorological Satellite Program satellites during the intense magnetic storm on 7–10 November 2004. It is found for the first time that quasi‐periodic enhancements in the ion density with a period of ∼6 hr occur nearly simultaneously at 0630, 0830, and 0930 local time in the dawn sector during the storm main phase with southward interplanetary magnetic field (IMF). The quasi‐periodic density enhancements extend from the southern subauroral latitudes to the northern subauroral latitudes. In the dusk sector, the topside ion density during the storm main phase is increased at middle latitudes for ∼12 hr but shows decrease or relatively small increase over the magnetic equator, indicating that penetration electric fields dominate the ion density redistribution. Similar quasi‐periodic enhancements in the topside ion density are also observed in the dawn sector during other intense magnetic storms. The solar wind and IMF do not have quasi‐periodic variations in this storm case. Periodic processes in geospace, such as periodic substorms in the magnetosphere, waves and tides in the atmosphere, and traveling ionospheric disturbances, cannot explain the observed periodic enhancements of the ionospheric ion density. We suggest that the magnetosphere‐ionospheric‐thermospheric system may have an intrinsic period of ∼6 hr and that oscillations of the magnetosphere‐ionospheric‐thermospheric system with this period can be excited during intense magnetic storms, although the mechanisms for the generation of the long‐periodic oscillations are not understood.
Thermal Balance and Water Ice Sublimation on the Surface of Hyperactive Comet 103P/Hartley 2
Authors: Yue Yuxian , Liu Jiancen , Wang Xiaohui
Published: December 2022

Hyperactive comets have attracted attention due to their high water production rate with an unclear mechanism, though some hypotheses have been proposed to explain it. Based on the thermal theories of the comet nuclei, this paper studied a comet surface thermal model considering the sublimation of H2O. In this paper, a method for solving the sublimation rate of water ice by infrared spectroscopy is proposed. The method adopts the assumption of subpixel temperature nonuniformity on the comet nucleus surface and uses the numerical solution of the Fredholm equation. We use the HRI‐IR spectrum (1.05–4.8 μm) data by EPOXI to analyze the pixel‐by‐pixel water sublimation rate of hyperactive comet 103P/Hartley 2. The results show that sublimation exists in most areas of the surface with or without surface roughness, and most of the water production rate (70%–90%) may come from the comet nucleus when Gauss random surface roughness is adopted. According to the sublimation law, it is estimated that the sublimation temperature of water ice on 103P is above 180 K. If the dust‐to‐ice volume ratio is 3:1, the sublimation temperature is about 200–210 K, which indicates that the water ice may sublimate underneath. This may explain why exposed water ice on the surface can hardly be observed while the active fraction of this comet is up to 100%.
Decoding the heterogeneity of Alzheimer’s disease diagnosis and progression using multilayer networks
Authors: Avelar-Pereira Bárbara , Belloy Michael E. , O’Hara Ruth , Hosseini S. M. Hadi ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: December 2022

Alzheimer’s disease (AD) is a multifactorial and heterogeneous disorder, which makes early detection a challenge. Studies have attempted to combine biomarkers to improve AD detection and predict progression. However, most of the existing work reports results in parallel or compares normalized findings but does not analyze data simultaneously. We tested a multi-dimensional network framework, applied to 490 subjects (cognitively normal [CN] = 147; mild cognitive impairment [MCI] = 287; AD = 56) from ADNI, to create a single model capable of capturing the heterogeneity and progression of AD. First, we constructed subject similarity networks for structural magnetic resonance imaging, amyloid-β positron emission tomography, cerebrospinal fluid, cognition, and genetics data and then applied multilayer community detection to find groups with shared similarities across modalities. Individuals were also followed-up longitudinally, with AD subjects having, on average, 4.5 years of follow-up. Our findings show that multilayer community detection allows for accurate identification of present and future AD (≈90%) and is also able to identify cases that were misdiagnosed clinically. From all MCI participants who developed AD or reverted to CN, the multilayer model correctly identified 90.8% and 88.5% of cases respectively. We observed similar subtypes across the full sample and when examining multimodal data from subjects with no AD pathology (i.e., amyloid negative). Finally, these results were also validated using an independent testing set. In summary, the multilayer framework is successful in detecting AD and provides unique insight into the heterogeneity of the disease by identifying subtypes that share similar multidisciplinary profiles of neurological, cognitive, pathological, and genetics information.
Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer
Authors: Yang Hanshen , Zhang Xiaozhen , Lao Mengyi , Sun Kang , He Lihong , Xu Jian , Duan Yi , Chen Yan , Ying Honggang , Li Muchun , Guo Chengxiang , Lu Qingsong , Wang Sicheng , Su Wei , Liang Tingbo , Bai Xueli
Published: December 2022

Programmed death-1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) help tumor cells evade immune surveillance, and are regarded as important targets of anti-tumor immunotherapy. Post-translational modification of PD-L1 has potential value in immunosuppression. Here, we identified that ubiquitin-specific protease 8 (USP8) deubiquitinates PD-L1. Pancreatic cancer tissues exhibited significantly increased USP8 levels compared with those in normal tissues. Clinically, the expression of USP8 showed a significant association with the tumor-node-metastasis stage in multiple patient-derived cohorts of pancreatic cancer. Meanwhile, USP8 deficiency could reduce tumor invasion and migration and tumor size in an immunity-dependent manner, and improve anti-tumor immunogenicity. USP8 inhibitor pretreatment led to reduced tumorigenesis and immunocompetent mice with Usp8 knockdown tumors exhibited extended survival. Moreover, USP8 interacted positively with PD-L1 and upregulated its expression by inhibiting the ubiquitination-regulated proteasome degradation pathway in pancreatic cancer. Combination therapy with a USP8 inhibitor and anti-PD-L1 effectively suppressed pancreatic tumor growth by activation of cytotoxic T-cells and the anti-tumor immunity was mainly dependent on the PD-L1 pathway and CD8 + T cells. Our findings highlight the importance of targeting USP8, which can sensitize PD-L1-targeted pancreatic cancer to immunotherapy and might represent a novel therapeutic strategy to treat patients with pancreatic tumors in the future.