bluuebunny/crossref_metadata_2025 huggingface dataset:
Table S2 from Antitumor Activity of a Novel LAIR1 Antagonist in Combination with Anti-PD1 to Treat Collagen-Rich Solid Tumors
Authors: Rodriguez Bertha L. , Huang Jiawei , Gibson Laura , Fradette Jared J. , Chen Hung-I.H. , Koyano Kikuye , Cortez Czrina , Li Betty , Ho Carmence , Ashique Amir M. , Lin Vicky Y. , Crawley Suzanne , Roda Julie M. , Chen Peirong , Fan Bin , Kim Jeong , Sissons James , Sitrin Jonathan , Kaplan Daniel D. , Gibbons Don L. , Rivera Lee B.
Published: August 2024

Summary of patient diagnoses and active treatment regimens selected for blood collection.
Supplemental Table 2 from First-in-Human Stage III/IV Melanoma Clinical Trial of Immune Priming Agent IFx-Hu2.0
Authors: Markowitz Joseph , Shamblott Michael , Brohl Andrew S. , Sarnaik Amod A. , Eroglu Zeynep , Khushalani Nikhil I. , Dukes Christopher W. , Chamizo Alejandra , Bastawrous Marina , Garcia Edward T. , Dehlawi Ashraf , Chen Pei-Ling , De Aquino Deanryan B. , Sondak Vernon K. , Tarhini Ahmad A. , Kim Youngchul , Lawman Patricia , Pilon-Thomas Shari
Published: August 2024

Number of lesions injected, Prior lines of therapy, time on post-protocol anti-PD1 therapy.
Supplementary Figure S2 from Targeting CD33+ Acute Myeloid Leukemia with GLK-33, a Lintuzumab–Auristatin Conjugate with a Wide Therapeutic Window
Authors: Satomaa Tero , Pynnönen Henna , Aitio Olli , Hiltunen Jukka O. , Pitkänen Virve , Lähteenmäki Tuula , Kotiranta Titta , Heiskanen Annamari , Hänninen Anna-Liisa , Niemelä Ritva , Helin Jari , Kuusanmäki Heikki , Vänttinen Ida , Rathod Ramji , Nieminen Anni I. , Yatkin Emrah , Heckman Caroline A. , Kontro Mika , Saarinen Juhani
Published: August 2024

GLK-33 binding and internalization to CD33+ cells.
Figure S4 from TNIK Inhibition Sensitizes TNIK-Overexpressing Lung Squamous Cell Carcinoma to Radiotherapy
Authors: Nguyen Triet , Carrieri Francesca A. , Connis Nick , Lafargue Audrey , Chang Jinhee , Chan Aaron , Shetty Amol C. , Song Yang , Hoang Tung , Jagtap Shreya , Chowdhury Dipanwita D. , Khan Muhammad A. , Gabrielson Kathleen L. , Rezaee Mohammad , Torres-Ayuso Pedro , Brognard John , Hann Christine L. , Tran Phuoc T.
Published: August 2024

TNIK depletion sensitized TNIKhigh LSCC to ionizing radiation.
Supplementary Figure 4 from NSCLC Extracellular Vesicles Containing miR-374a-5p Promote Leptomeningeal Metastasis by Influencing Blood‒Brain Barrier Permeability
Authors: Jin Jie , Cui Yumeng , Niu Huicong , Lin Yanli , Wu Xiaojie , Qi Xuejiao , Bai Kaixuan , Zhang Yu , Wang Youliang , Bu Hui
Published: August 2024

miR-374a-5p reduces cell-cell junctions and does not reduce the amount of tight junction protein.
Supplemental Figure 2 from Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer
Authors: Ho Chi-Lee C. , Gilbert Michael B. , Urtecho Guillaume , Lee Hyoungjoo , Drew David A. , Klempner Samuel J. , Cho Jin S. , Ryan Thomas J. , Rustgi Naryan , Lee Hyuk , Lee Jeeyun , Caraballo Alexander , Magicheva-Gupta Marina V. , Rios Carmen , Shin Alice E. , Tseng Yuen-Yi , Davis Jeremy L. , Chung Daniel C. , Chan Andrew T. , Wang Harris H. , Ryeom Sandra
Published: August 2024

Supplemental Figure 2 contains stomach immunofluorescence images for Figure 3B.
Supplemental Table 3 from Colon Age: A Metric for Whether and How to Screen Male Veterans for Early-Onset Colorectal Cancer
Authors: Imperiale Thomas F. , Myers Laura J. , Barker Barry C. , Stump Timothy E. , Daggy Joanne K.
Published: August 2024

Supplemental Table 3: Recommended Screening Based on Revised SEER Rate for Complete Data from Full Cohort
Supplementary Figure 19 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Equilibration of interactions that drives ATP affinity in the presence MET F1200I mutant. (A) Representative structure of ATP bound MET F1200I with the regions of interest highlighted [alpha C helix (red), DFG site (green), mutation site (blue)]. (B) π - π stacking interactions that bridge the alpha C helix and DFG site are conformationally controlled through residues position 1200. π - π stacking interactions were calculated between ring centers. Distances between F1200I and neighboring residues were measured from the F1200I side chain center of mass to the ring centers of the aromatic rings. (C) root-mean-square-fluctuation (RMSF) calculations show a stabilization of the activation loop in the F1200I system.
Data from Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression
Authors: Liu Yiman , Li Qinglan , Song Lele , Gong Chujie , Tang Sylvia , Budinich Krista A. , Vanderbeck Ashley , Mathias Kaeli M. , Wertheim Gerald B. , Nguyen Son C. , Outen Riley , Joyce Eric F. , Maillard Ivan , Wan Liling
Published: August 2024

Abstract
Gain-of-function mutations in the histone acetylation “reader” eleven-nineteen-leukemia (ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive condensate formation and gene activation in cellular systems. However, their role in tumorigenesis remains unclear. Using a conditional knock-in mouse model, we show that mutant ENL perturbs normal hematopoiesis, induces aberrant expansion of myeloid progenitors, and triggers rapid onset of aggressive AML. Mutant ENL alters developmental and inflammatory gene programs in part by remodeling histone modifications. Mutant ENL forms condensates in hematopoietic stem/progenitor cells at key leukemogenic genes, and disrupting condensate formation via mutagenesis impairs its chromatin and oncogenic function. Moreover, treatment with an acetyl-binding inhibitor of the mutant ENL displaces these condensates from target loci, inhibits mutant ENL-induced chromatin changes, and delays AML initiation and progression in vivo. Our study elucidates the function of ENL mutations in chromatin regulation and tumorigenesis and demonstrates the potential of targeting pathogenic condensates in cancer treatment.

Significance: A direct link between ENL mutations, condensate formation, and tumorigenesis is lacking. This study elucidates the function and mechanism of ENL mutations in leukemogenesis, establishing these mutations as bona fide oncogenic drivers. Our results also support the role of condensate dysregulation in cancer and reveal strategies to target pathogenic condensates.
Supplementary Figure S13 from CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity
Authors: Mehta Naveen K. , Rakhra Kavya , Meetze Kristan A. , Li Bochong , Momin Noor , Chang Jason Y.H. , Wittrup K. Dane , Baeuerle Patrick A. , Michaelson Jennifer S.
Published: August 2024

Tumor clonotype correlations
Figure S7 from Venetoclax Induces BCL-2–Dependent Treg to TH17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade
Authors: Liao Rosy , Hsu Jocelyn Y. , Aboelella Nada S. , McKeever Joshua A. , Thomas-Toth Anika T. , Koh Andrew S. , LaBelle James L.
Published: August 2024

Supplementary Figure S7. RORγt+ expression increases following venetoclax treatment in BCL-2lo and BCL-2hi Tregs.
Figure S3 from Venetoclax Induces BCL-2–Dependent Treg to TH17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade
Authors: Liao Rosy , Hsu Jocelyn Y. , Aboelella Nada S. , McKeever Joshua A. , Thomas-Toth Anika T. , Koh Andrew S. , LaBelle James L.
Published: August 2024

Supplementary Figure S3. Effects of venetoclax on T cell numbers are reserved following 14day drug holiday.
Supplementary Figure S8 from Overexpression of an Engineered SERPINB9 Enhances Allogeneic T-cell Persistence and Efficacy
Authors: Teo Pei Y. , Jung Youngrock , Quach David H. , Koh Joanna , Ong Richard W. , Goh Angeline , Tan Alrina , Ng Chee H. , Seh Cheah C. , Tan Kar W. , Horak Ivan D. , Low Lionel
Published: August 2024

Supplementary Figure S8. Overexpression of SB9(CAS) in ‘donor’ CD30.CAR with IgG1 spacer (CD30.Ig) TCRαβKO ATCs increases resistance to allorejection by ‘recipient’ Allo-T cells. A, Schematic of in-vitro MLR co-culture setup for (B-E), where ‘donor’ CD30.Ig TCRαβKO ATCs and ‘recipient’ Allo-T cells, which are CD30KO ATCs that were primed to recognize and kill ‘donor’ cells, were mixed at a 1:1 ratio. The MLR was performed in the presence of IL-7 and IL-15, both at 10 ng/mL. B-D, Cell counts, from a representative ‘donor’-recipient pair, of ‘donor’ T cells growing in monoculture (B), or ‘donor’ T cells (C) and ‘recipient’ Allo-T cells (D) in co-culture. E, The day 3 ‘donor’ cell death (%), where each point represents a unique ‘donor’-‘recipient’ pair and the bar chart represents the median (n = 6 per treatment group). P values were determined by one-way ANOVA, followed by Tukey post-test (E). *, P < 0.05; **, P < 0.01, ****, P < 0.0001.
Supplementary Figure S2 from Overexpression of an Engineered SERPINB9 Enhances Allogeneic T-cell Persistence and Efficacy
Authors: Teo Pei Y. , Jung Youngrock , Quach David H. , Koh Joanna , Ong Richard W. , Goh Angeline , Tan Alrina , Ng Chee H. , Seh Cheah C. , Tan Kar W. , Horak Ivan D. , Low Lionel
Published: August 2024

Supplementary Figure S2. Mixed lymphocyte reaction assay with TCRαβKO ATCs. A, Expression of TCRαβ on CD3 wild-type (WT) T cells or T cells after TCRαβKO gene modification using Crispr gene editing measured by flow cytometry analysis. B, Expression of different variants of SB9 on TCRαβKO ATCs measured by intracellular flow cytometry analysis of one representative donor. C, Relative geometric mean fluorescence intensity (MFI) of different variants of SB9, normalized to SB9 expression in NT sample. The bars denote median ± SD (n = 3 donors). D, Cell counts, by flow cytometric analysis, of ‘recipient’ CD3-CD56+ NK cells that were in co-culture with ‘donor’ TCRαβKO ATCs in a mixed-lymphocyte reaction study, from the same representative ‘donor’-‘recipient’ pair as shown in Fig. 1C–E.
Supplementary Figure S10 from Overexpression of an Engineered SERPINB9 Enhances Allogeneic T-cell Persistence and Efficacy
Authors: Teo Pei Y. , Jung Youngrock , Quach David H. , Koh Joanna , Ong Richard W. , Goh Angeline , Tan Alrina , Ng Chee H. , Seh Cheah C. , Tan Kar W. , Horak Ivan D. , Low Lionel
Published: August 2024

Supplementary Figure S10. Overexpression of SB9(CAS) on CD19.CAR TCRαβKO ATCs reduces the amount of caspase 8 active p18 fragment produced. A and C, SDS-PAGE analysis of caspase 8 expression in CD19.CAR TCRαβKO ATCs, where the caspase 8 active fragment p18 is located at 18 kDa. The corresponding calnexin expression of the same membrane is also shown at 90 kDa. B and D, Densitometry analysis of caspase 8 active fragment p18 normalized to CD19.CAR control and calnexin as the loading control, at each time point.
Supplementary Table S1-S3 from mTOR Signaling Promotes Rapid m6A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
Authors: Meng Meng , Zhong Zhaoyang , Song Liang , Zhang Zhaohui , Yin Xiaofeng , Xie Xiqiang , Tian Lei , Wu Wei , Yang Yao , Deng Yafei , Peng Hongyan , Wu Shuting , Ran Guanghe , Lin Yuqing , Lai Qiangqiang , Bi Qinghua , Yan Fulin , Ji Yan , Wang Yang , Li Xiaohui , Yi Ping , Yu Jianhua , Deng Youcai
Published: August 2024

Supplementary Table S1-S3
Supplementary Figure S2 from mTOR Signaling Promotes Rapid m6A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
Authors: Meng Meng , Zhong Zhaoyang , Song Liang , Zhang Zhaohui , Yin Xiaofeng , Xie Xiqiang , Tian Lei , Wu Wei , Yang Yao , Deng Yafei , Peng Hongyan , Wu Shuting , Ran Guanghe , Lin Yuqing , Lai Qiangqiang , Bi Qinghua , Yan Fulin , Ji Yan , Wang Yang , Li Xiaohui , Yi Ping , Yu Jianhua , Deng Youcai
Published: August 2024

Supplementary Figure S2
Supplementary Figure S3 from Low Serum Apolipoprotein A1 Levels Impair Antitumor Immunity of CD8+ T Cells via the HIF-1α–Glycolysis Pathway
Authors: Lv Qiaoying , Su Tong , Liu Wei , Wang Lulu , Hu Jiali , Cheng Yali , Ning Chengcheng , Shan Weiwei , Luo Xuezhen , Chen Xiaojun
Published: August 2024

Supplementary Figure S3. ApoA1 exerts its antitumor activity in a CD8 +T cell–dependent manner (related to Figure 3)
Data from T-Cell Expression of CXCL13 is Associated with Immunotherapy Response in a Sex-Dependent Manner in Patients with Lung Cancer
Authors: Brennan Michelle , DeBruin David , Nwokolo Chinye , Hunt Katey S. , Piening Alexander , Donlin Maureen J. , Ferris Stephen T. , Teague Ryan M. , DiPaolo Richard J. , Alspach Elise
Published: August 2024

Abstract
Emerging evidence in preclinical models demonstrates that antitumor immunity is not equivalent between males and females. However, more investigation in patients and across a wider range of cancer types is needed to fully understand sex as a variable in tumor immune responses. We investigated differences in T-cell responses between male and female patients with lung cancer by performing sex-based analysis of single cell transcriptomic datasets. We found that the transcript encoding CXC motif chemokine ligand 13 (CXCL13), which has recently been shown to correlate with T-cell tumor specificity, is expressed at greater levels in T cells isolated from female compared with male patients. Furthermore, increased CXCL13 expression was associated with response to PD1–targeting immunotherapy in female but not male patients. These findings suggest that there are sex-based differences in T-cell function required for response to anti–PD1 therapy in lung cancer that may need to be considered during patient treatment decisions.

See related Spotlight by Cruz-Hinojoza and Stromnes, p. 952
Supplementary Figure S4 from p300 KAT Regulates SOX10 Stability and Function in Human Melanoma
Authors: Waddell Aaron , Grbic Nicole , Leibowitz Kassidy , Wyant William Austin , Choudhury Sabah , Park Kihyun , Collard Marianne , Cole Philip A. , Alani Rhoda M.
Published: August 2024

This figure illustrates the effects of A-485 on SOX10 protein expression without effects on SOX10 gene expression.
Bridging the Gap between Intuition and Theory: A Comparison of Different Approaches to Implementation Strategy Development for Improving Lynch Syndrome Detection
Authors: Morrow April , Chan Priscilla , Tiernan Gabriella , Kennedy Elizabeth , Steinberg Julia , Hogden Emily , Debono Deborah , Taylor Natalie
Published: August 2024

Introduction: Despite growing calls for the explicit application of theory when designing behaviour change interventions, limited empirical evidence exists regarding the effectiveness of these methods compared to non-theoretical approaches. A cluster randomized controlled trial (Hide and Seek Project – HaSP) tested two implementation approaches for improving hereditary cancer referral practices with one key distinction: implementation strategies were designed based explicitly on psychological theory or based on stakeholder intuition. This study presents the detailed methods and resources used to facilitate this comparison, whilst examining the strategies generated through both approaches. Methods: Across seven Australian hospitals, clinical stakeholders attended focus groups to co-design site-specific strategies for improving Lynch syndrome referral. Co-design methods differed according to trial arm. Implementation strategy content was examined, with intuitively derived strategies retrospectively coded to determine theoretical alignment. Results: Fifty-one strategies were proposed across all sites (theory-based arm = 32, intuition-based arm = 19). Overall, nine behaviour change technique (BCT) categories were used on 77 occasions. In the theory-based trial arm, eight BCT categories were identified on 53 occasions; and five BCT categories on 24 occasions in the intuition-based arm. BCT categories were largely similar across both arms. After retrospectively coding intuitively derived strategies, 42% contained mechanistic links, thereby demonstrating theoretical alignment. Conclusion: Methods facilitated robust comparison of theoretical and intuitive approaches to implementation strategy design. Recognizing the known benefits of theory for enhancing scientific learning, applying these methods on a larger scale may provide definitive evidence about the comparative effectiveness of theoretical approaches.
Membranoproliferative glomerulonephritis over 20 years at a tertiary referral center in the United Kingdom
Authors: O'Keeffe Hannah , Storrar Joshua , Ramakrishna Chethana , Metaoy Sara , Chrysochou Constantina , Chinnadurai Rajkumar , Kalra Philip A. , Sinha Smeeta
Published: August 2024

Introduction
Membranoproliferative glomerulonephritis (MPGN) is a pattern of injury seen on kidney biopsy, with various underlying etiologies. The component types, including complement-mediated MPGN, are relatively rare. This study presents longitudinal real-world data over 20 years in a tertiary renal center in the United Kingdom.

Methods
All patients with an MPGN pattern on kidney biopsy between 2000 and 2020 were identified. After applying exclusion criteria, 38 patients remained. Data including patient demographics, details of the renal histology from the kidney biopsy, baseline laboratory results, treatments received, and clinical outcomes including renal replacement therapy and death were collected from the organization’s electronic patient record.

Results
28 of the cohort had immune complex-mediated MPGN, and 10 had complement-mediated MPGN (8 with C3 glomerulonephritis and 2 with Dense Deposit Disease). Median follow up was 72 months. Median age was 61 years. 60.5% were female, and 92.1% white. At presentation median eGFR was 31.5 ml/min/1.73m2 and uPCR 394 mg/mmol. 78.9% received renin-angiotensin-aldosterone system inhibitors and 71.1% received any immunosuppression. 47.4% progressed to ESKD and 50% died during follow up.

Conclusions
The study found an older patient population than typically reported. Poor outcomes were observed in the overall cohort with progression to ESKD and mortality both at almost 50%. This may be influenced by the older patient population. Individualized management of patients with an MPGN biopsy finding is paramount, with comprehensive evaluation for triggers and complement abnormalities. Going forward, registry enrolment and collaborative studies may enhance knowledge and outcomes.
O jogo da amarelinha: saltos para a institucionalização da geografia cultural no Brasil
Authors: Valverde Rodrigo R.H.F. ,   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas
Published: August 2024

Este livro se dedica ao estudo de diferentes definições geográficas de cultura e da seletiva e parcial adoção destas na Geografia desenvolvida no Brasil. A partir de uma abordagem contextual, procura-se diferenciar as formas do estudo da cultura na Geografia não apenas pelos temas desenvolvidos, mas também pelos métodos e justificativas para cada uma de suas formas de trabalho. Ao fazê-lo, desafiam-se entendimentos consolidados na História do Pensamento Geográfico para pensar a Geografia Cultural, como aqueles que se voltam para a estabilidade de uma forma única de pesquisa, ou para o caráter exclusivamente experimental de seus conteúdos, ou, ainda, para uma única ideologia que a anima. Na parte final da obra, discutem-se as condições para o surgimento de formas brasileiras de abordagens da cultura. O livro defende a coexistência de diversas formas de Geografia, além de sugerir que os conteúdos da Geografia Cultural sejam incluídos durante os anos de formação do bacharelado nas universidades do Brasil.
A partilha de tarefas públicas entre Administração Pública e empresas: a busca por um novo equilíbrio
Authors: Pessoa Robertonio Santos
Published: August 2024

The article examines the public tasks reserved to the social state and how these tasks have been compromised by the advancement of various privatization processes. Under the allegation of the need to open the public sector to competition, the public monopoly gradually gave way to new monopolies and oligopolies, this time of a private nature. State management of public services has been replaced by business management, in the form of public-private partnerships. This resulted in a significant setback in the State's capacity for direct intervention in the economic and social fields. In the current context marked by the hegemony of neoliberal ideology, the viability of the permanence of the sum division that marked the development of political-legal thought, that is, the dichotomy of public tasks and private tasks, and how a sharing can be carried out is revisited. of responsibility between the State and companies in complex societies based on this division, without compromising the intervention powers inherent to a social State.
HCC-1 Accelerates Atherosclerosis by Inducing Endothelial Cell and Macrophage Pyroptosis and Serves as an Early Diagnostic Biomarker
Authors: Bu Fan , Wang Junhui , Chen Juanjiang , Zhang Qi , Lin Xiaomin , Zhang Ruyi , Bai Huanlan , Hua Yuneng , Wang Haifang , Huang Mei , Huang Yiyi , Lin Yuling , Hu Xiumei , Zheng Lei , Wang Qian
Published: August 2024

BACKGROUND:

HCC-1 (hemofiltrate CC chemokine-1), a CC-type chemokine, exerts function to change intracellular calcium concentration, induce leukocyte, and manipulate enzyme release especially in monocytes. It has been reported that HCC-1 can predict the persistent acute kidney injury or suppress hepatocellular carcinoma by modulating cell cycle and promoting apoptosis; however, the effect of HCC-1 on atherosclerosis is poorly understood. Here, we aimed to clarify the function and mechanism of HCC-1 in atherosclerosis and whether it could serve as a novel biomarker for the diagnosis of atherosclerosis.

METHODS:

HCC-1 expression in serum, atherosclerotic plaques, and normal arterial tissue from patients with atherosclerosis and control group was assessed by ELISA, immunohistochemistry and confocal microscope, and bioinformatic analysis. The atherosclerotic model of HCC-1 overexpressing and control mice was generated by tail vein injection of adeno-associated virus serotype 9–HCC-1 on an ApoE
−/−
background. Cell adhesion, polarization, and pyroptosis were evaluated in vitro. The relationship between HCC-1 concentration in serum and atherosclerosis was analyzed in patients with atherosclerosis.

RESULTS:

HCC-1 expression was positively correlated with the occurrence and stable-unstable switch of atherosclerosis under bioinformatic analysis, which is further supported by the results of increased HCC-1 expression in atherosclerosis patients both in serum and atherosclerotic plaque. adeno-associated virus serotype 9–HCC-1 mice had higher levels of inflammatory factors, increased macrophage accumulation and pyroptotic rate in plaque, and decreased atherosclerotic plaque stability. In vitro, HCC-1 promoted monocyte adhesion and M1 polarization and induced inflammation and pyroptosis both in endothelial cells and macrophages.

CONCLUSIONS:

HCC-1 expression was increased in patients with atherosclerosis, and HCC-1 overexpression accelerated atherosclerotic burden via an enhancement in monocyte recruitment, M1 polarization, and pyroptosis both in endothelial cells and macrophages. Our findings suggested that HCC-1 may serve as an early biomarker for the diagnosis of atherosclerosis, with the capacity to reflect the degree of stenosis.
Lexical Surprisal Shapes the Time Course of Syntactic Structure Building
Authors: Slaats Sophie , Meyer Antje S. , Martin Andrea E.
Published: August 2024

When we understand language, we recognize words and combine them into sentences. In this article, we explore the hypothesis that listeners use probabilistic information about words to build syntactic structure. Recent work has shown that lexical probability and syntactic structure both modulate the delta-band (<4 Hz) neural signal. Here, we investigated whether the neural encoding of syntactic structure changes as a function of the distributional properties of a word. To this end, we analyzed MEG data of 24 native speakers of Dutch who listened to three fairytales with a total duration of 49 min. Using temporal response functions and a cumulative model-comparison approach, we evaluated the contributions of syntactic and distributional features to the variance in the delta-band neural signal. This revealed that lexical surprisal values (a distributional feature), as well as bottom-up node counts (a syntactic feature) positively contributed to the model of the delta-band neural signal. Subsequently, we compared responses to the syntactic feature between words with high- and low-surprisal values. This revealed a delay in the response to the syntactic feature as a consequence of the surprisal value of the word: high-surprisal values were associated with a delayed response to the syntactic feature by 150–190 ms. The delay was not affected by word duration, and did not have a lexical origin. These findings suggest that the brain uses probabilistic information to infer syntactic structure, and highlight an importance for the role of time in this process.
Where There Is Unity, Order Results: Manufacturers’ Labels and the Creation of Standards in the Late Warring States Period
Authors: Škrabal Ondřej
Published: August 2024

This article explores how and why standardization practices emerged and evolved in a particular domain of state administration in China in the late Warring States period, namely, the inscription of manufacturers’ labels on bronze weapons produced in state-run workshops. By analyzing bronze weapons produced in the state of Hán in the third century BCE, the study highlights the evolution of standards via gradual refinement rather than abrupt innovation, the interplay of central and regional governments and workshops in the reformulation of standards, and trailblazing micro-management in the major production center in the Hán capital of Zheng. The standardization efforts in Hán help us better understand the developments in administration at the very end of the Warring States period and provide a new context for the famous standardizations introduced after the Qin unification of China in 221 BCE.
Active Surface-Enhanced Raman Spectroscopy (SERS): A Novel Concept for Enhancing Signal Contrast in Complex Matrices Using External Perturbation
Authors: Mosca Sara , Mehta Megha , Skinner William H. , Gardner Benjamin , Palombo Francesca , Stone Nicholas , Matousek Pavel
Published: August 2024

Noninvasive detection of surface-enhanced Raman spectroscopy (SERS) signals from deep within tissue represents a common challenge in many biological and clinical applications including disease diagnosis and therapy monitoring. Such signals are typically weak and not readily discernible from often much larger Raman and fluorescence background signals (e.g., from surrounding tissue). Consequently, suboptimal sensitivity in the detection of SERS signals is often achieved in these situations. Similar issues can arise in SERS measurements in other diffusely scattering samples and complex matrices. Here, we propose a novel concept, active SERS, for the efficient retrieval of SERS signals from deep within complex matrices such as biological tissues that mitigates these issues. It relies on applying an external perturbation to the sample to alter the SERS signal from nanoparticles (NPs) deep inside the matrix. A measurement with and without, or before and after, such perturbation then can provide powerful contrasting data enabling an effective elimination of the matrix signals to reveal more clearly the desired SERS signal without the interfering background and associated artifacts. The concept is demonstrated using ultrasound (US) as an external source of perturbation and SERS NPs inserted deep within a heterogeneous tissue phantom mimicking a cluster of NPs accumulated within a small target lesion. The overall SERS signal intensity induced by the applied US perturbation decreased by ∼21% and the SERS signal contrast was considerably improved by eliminating subtraction artifacts present in a conventional measurement performed at a neighboring spatial location in a heterogeneous tissue sample. Although the technique was demonstrated with SERS gold NPs with a standard Raman label, it is envisaged that active SERS NPs (both the nanoscale metal geometry and Raman label) could be specifically designed to deliver an augmented response to the external stimulus to further enhance the achievable SERS signal contrast and yield even greater improvement in detection sensitivity. The method was demonstrated using transmission Raman spectroscopy; however, it is also applicable to other Raman implementations including spatially offset Raman spectroscopy and conventional Raman spectroscopy performed both at depth and at surfaces of complex matrices.
Nondispersive Ultraviolet Visible Gas Analyzer for Monitoring Molybdenum Chloride and Oxychloride Precursors During Vapor Deposition Processes
Authors: Maslar James E. , Kalanyan Berc
Published: August 2024

Nondispersive ultraviolet visible gas analyzer designs were evaluated for monitoring molybdenum-containing chloride and oxychloride precursor delivery during microelectronics vapor deposition processes. The performances of three analyzer designs, which differed only in the bandpass filter employed for wavelength selection, were compared for measuring the partial pressure of molybdenum pentachloride, molybdenum oxytetrachloride (MoOCl4), and molybdenum dioxydichloride (MoO2Cl2). The analyzer's optical response with a 369 nm center wavelength filter for molybdenum pentachloride was determined by measuring the molybdenum pentachloride absorbance as a function of vapor molar density. The calibrated analyzer was transferred to a process line on a deposition chamber and used to measure the molybdenum pentachloride partial pressure during delivery in a flowing carrier gas. The molybdenum pentachloride minimum detectable density was determined to be 1 × 10–4 mol m–3 (0.35 Pa for a cell temperature of 145 °C), for data collected at 1 kHz and referenced to a 0.2 s duration background. The analyzer optical response for molybdenum pentachloride with the two other filters and the response for MoOCl4 and MoO2Cl2 with all three filters were simulated with a simple model. These data were used to evaluate the sensitivity and selectivity of analyzers incorporating the different filters to some likely combinations of analytes and interferents.
Opinion leaders’ influence on knowledge transmission about crop diseases management: Exploring the attributes that matter to followers
Authors: Kabirigi Michel , Adewopo Julius B , Sun Zhanli , Hermans Frans
Published: August 2024

Opinion leaders play a significant role in promoting innovation and technology adoption through effective information dissemination to potential adopters. However, personal traits that define effective opinion leaders, as identified in existing literature, may not fully align with followers’ desired attributes of an opinion leader. Additionally, little is known about how varying degrees of influence may impact the spread of knowledge. To bridge the gap, first, we conducted focus group discussions in 10 villages within the banana farming community in Rwanda to assess the critical attributes that farmers seek in opinion leaders. Results indicate that honesty, commitment, social, knowledge, and leading by example are the top five attributes that farmers value the most from an opinion leader for the control of Banana Xanthomonas Wilt – a major banana disease. Second, we collected data from 100 nominated opinion leaders, including 10 farmer promoters, using a structured questionnaire to determine how they transmit knowledge about disease management to farmers. The opinion leaders were categorised into low, medium, and high levels of influence based on pairwise comparison. We found that honesty, leading by example, and justice are significant attributes that distinguish opinion leaders with a higher level of influence and who are more effective in transmitting knowledge. Farmer promoters are not distinct from other opinion leaders in terms of access to farmers but are more active in knowledge transmission than any other opinion leader. Our results suggest that having access to farmers does not indicate influence. Therefore, we recommend engaging those farmer promoters and opinion leaders with a higher level of influence to disseminate information to farmers at the village level.
The Fetishization of Sport: Exploring the Effects of Fetishistic Disavowal in Sportswashing
Authors: Black Jack , Sinclair Gary , Kearns Colm
Published: August 2024

Is it possible to remain a sports fan when prominent sports teams and events are utilized to “sportswash” human rights abuses and other controversies? Indeed, while there is an abundance of analyses critiquing different instances of sportswashing, the exploration of the role of sportswashing and its connection to the “sports fan” presents an essential and necessary area of investigation and theoretical inquiry. To unpick this dilemma, this article proposes the concept of “fetishistic disavowal” to help theorize the impact of sportswashing, as well as its relation to the sports fan and critical sports academic. This argues that, as spectators and fans of sport—and, moreover, as critical academics—we often acknowledge and accept that sport is used to perpetuate and even maintain a variety of social, economic, and political inequalities. Yet, while we are aware of such knowledge, we nonetheless remain fully capable of disavowing this very knowledge as an accepted part of sport. Given this, it is argued that the fetishization of sport can provide a suitable conduit for the fetishistic disavowal that sportswashing requires, with the concept offering a unique way of approaching sport's inherent contradictions, while also theorizing how subjects relate to these contradictions as part of their involvement in and with sport. Where sportswashing directly implicates the fan in its implementation—relying upon a level of fetishistic disavowal between the fan and their club and proffering a disavowed acknowledgement of the effects of sportswashing and its interpellation through sport—this article outlines how applications of fetishistic disavowal provide a unique theoretical lens through which analyses of sport, and its ethical significance, can be critiqued.
Exploring the next generation Internet of Things (IoT) requirements and applications: A comprehensive overview
Authors: Idhalama Ogagaoghene Uzezi , Oredo John Otieno
Published: August 2024

This research abstract provides a comprehensive overview of exploring the requirements and applications of the next generation Internet of Things (IoT). The study which used thorough literature review as methodology, involved a systematic search of relevant academic databases, such as Scopus, IEEE Xplore, and ACM Digital Library, using keywords such as “Internet of Things,” “next-generation IoT,” “IoT requirements,” and “IoT applications.” The search was limited to peer-reviewed journal articles, conference proceedings, and book chapters published within the last ten years to ensure the inclusion of the most recent and relevant information. It focused on identifying the key requirements for the next generation of Internet of Things (IoT) technologies, evaluating the current state of IoT applications and identify areas of improvement for future generations, investigating the potential impact of next-generation IoT on various industries and sectors. Other objectives of the study are: analysing the data security and privacy challenges that may arise with the implementation of next-generation IoT technologies, examining the potential environmental impact of next-generation IoT devices and propose sustainable solutions, investigating the use of artificial intelligence and machine learning algorithms for enhancing the capabilities of IoT applications and the future perspectives of internet of things. Additionally, the research delves into the diverse range of applications that can benefit from the next generation IoT. These applications span across industries such as healthcare, agriculture, transportation, and smart cities. The IoT enables improved efficiency, automation of processes, and better decision-making in various sectors. The findings highlight the need for holistic approaches to address the requirements and challenges of the next generation IoT. By focusing on interoperability, standardization, security, and data management, researchers and industry professionals can ensure the continued success and advancements of the IoT.
Studies on Moral Judgment and Cognition Involving Cryptocurrencies and Tax Evasion
Authors: Grym Jori , Aspara Jaakko , Liljander Veronica
Published: August 2024

Although new digital monetary instruments (e.g., cryptocurrencies) have emerged and proliferated, there is little academic research concerning consumer perspectives on these instruments or the effects of these instruments on consumers’ moral judgments. The present research addressed this gap in the literature by addressing the following research question: Is the morality of tax evasion judged differently when tax evasion is undertaken with cryptocurrency vs. traditional financial instruments (e.g., stocks)? In two online experiments, we exposed participants to a tax evasion scenario with either cryptocurrency or stock trading. The results of Study 1 showed that tax evasion is perceived as being less wrong when it is carried out with cryptocurrency trading rather than stock trading. Study 2 replicated Study 1 and tested an explanatory mediating mechanism hypothesized to underlie the main effect. A mediation analysis showed that the effect of cryptocurrency (vs. stock trading) on the perceived wrongness of tax evasion is partially mediated by the observer's positive (vs. negative) affective evaluation of the person committing tax evasion. This paper also discusses the theoretical, practical, and societal implications of the present results, including the likelihood that people's attitudes toward moral transgressions and crimes will be more lenient when these acts are conducted with new, innovative, and exciting instruments.
The usefulness of contrast-enhanced subtraction magnetic resonance imaging for detecting endoleaks after endovascular aortic repair with prophylactic intraoperative sac embolization
Authors: Kamisako Atsufumi , Nakai Motoki , Saguchi Toru , Tanaka Taro , Okada Yukinori , Ishida Masanori , Saito Kazuhiro
Published: August 2024

Background

Metallic and hyperdense artifacts and T1-shortening substances in the abdominal aortic aneurysm (AAA) sac generated by embolic materials and lipiodol pose challenges in the identification of endoleaks on follow-up computed tomography (CT) or magnetic resonance imaging (MRI).

Purpose

To evaluate the usefulness of contrast-enhanced subtraction MRI (CES-MRI) for detecting endoleaks after endovascular abdominal aortic aneurysm repair (EVAR) with intraoperative AAA sac embolization compared with CE-CT, this study was conducted.

Material and Methods

In this study, 28 consecutive patients who underwent EVAR with prophylactic AAA sac embolization were included. All patients underwent CES-MRI and CE-CT to detect endoleaks. The definitive diagnosis of endoleaks was a consensus reading of CE-CT and CES-MRI by two certified radiologists, in addition to angiography or reproducible radiological findings in the observational examination. Analysis was performed to evaluate which examination was better for detecting endoleaks.

Results

The sensitivity, specificity, and area under the curve of CE-CT and CES-MRI according to observer 1 were 50%, 100%, and 0.813 (95% confidence interval [CI] = 0.625–1.00) and 100%, 95%, and 0.997 (95% CI = 0.984–1.00), respectively, and those according to observer 2 were 50%, 100%, and 0.750 (95% CI = 0.514–0.986) and 100%, 95%, and 0.969 (95% CI = 0.903–1.00), respectively. Intolerable artifacts were significantly observed on CE-CT. The severity of the artifacts did not depend on the stent graft on CT and MRI.

Conclusion

Although no significant difference was observed, CES-MRI tended to have better accuracy for endoleak detection in EVAR with intraoperative AAA sac embolization than CE-CT.
Practical Advice on Measuring and Applying Light for Laboratory Mammals
Authors: Lucas Robert J. , Peirson Stuart N.
Published: August 2024

Light is recognized as an important component of the environment for laboratory animals. It supports vision, sets the phase of circadian clocks, and drives wide-ranging adjustments in physiological and behavioral state. Manipulating light is meanwhile a key experimental approach in the fields of vision science and chronobiology. Nevertheless, until recently, there has been no consensus on methods for quantifying light as experienced by laboratory animals. Widely adopted practices employ metrics such as illuminance (units = lux) that are designed to quantify light as experienced by human observers. These weight energy across the spectrum according to a spectral sensitivity profile for human vision that is not widely replicated for non-human species. Recently, a Consensus View was published that proposes methods of light measurement and standardization that take account of these species-specific differences in wavelength sensitivity. Here, we draw upon the contents of that consensus to provide simplified advice on light measurement in laboratory mammal experimentation and husbandry and quantitative guidance on what constitutes appropriate lighting for both visual and circadian function.
Urine Output and Development of Acute Kidney Injury in Sepsis: A Multicenter Observational Study
Authors: Yamamoto Ryo , Yamakawa Kazuma , Yoshizawa Jo , Kaito Daiki , Umemura Yutaka , Homma Koichiro , Sasaki Junichi
Published: August 2024

Background

Acute kidney injury (AKI) is common in sepsis and a urine output <0.5 mL/kg/h associated with increased mortality is incorporated into AKI diagnosis. We aimed to identify the urine-output threshold associated with increased AKI incidence and hypothesized that a higher urine output than a specified threshold, which differs from the predominantly used 0.5 mL/kg/h threshold, would be associated with an increased AKI incidence.

Methods

This was a post-hoc analysis of a nationwide prospective observational study. This study included adult patients newly diagnosed with sepsis and requiring intensive care. Urine output on the day of sepsis diagnosis was categorized as low, moderate, or high (<0.5, 0.5-1.0, and >1.0 mL/kg/h, respectively), and we compared AKI incidence, renal replacement therapy (RRT) requirement, and 28-day survival by category. Estimated probabilities for these outcomes were also compared after adjusting for patient background and hourly fluid administration.

Results

Among 172 eligible patients, AKI occurred in 46.3%, 48.3%, and 53.1% of those with high, moderate, and low urine output, respectively. The probability of AKI was lower in patients with high urine output than in those with low output (43.6% vs 56.5%; P = .028), whereas RRT requirement was lower in patients with high and moderate urine output (11.7% and 12.8% vs 49.1%; P < .001). Patients with low urine output demonstrated significantly lower survival (87.7% vs 82.8% and 67.8%; P = .018). Cubic spline curves for AKI, RRT, and survival prediction indicated different urine-output thresholds, including <1.2 to 1.3 mL/kg/h for AKI and <0.6 to 0.8 mL/kg/h for RRT and mortality risk.

Conclusions

Urine output >1.0 mL/kg/h on the day of sepsis diagnosis was associated with lower AKI incidence. The urine-output threshold was higher for developing AKI than for RRT requirement or mortality.
Characterization of thermoplastic composite joints fabricated by the combined refill friction stir spot welding and riveting process
Authors: Ohashi Ryoji , Hatano Ryoichi , Haruna Shunsuke
Published: August 2024

Carbon fiber-reinforced thermoplastics have been extensively studied to reduce the weight of transportation equipment. In this study, to enhance the interlocking effect of Ti-6Al-4V rivets, the new riveting process combined with refill friction stir spot welding (FSSW) was attempted. Consequently, the successful combination of refill FSSW and riveting resulted in a flared trumpet-shaped rivet, expanding the diameter of its tip significantly. Tensile shear tests exhibited both the stirred zone induced by refill FSSW and the flared rivet affected the fracture behavior. The cross-sectional observations revealed the existence of cracks at the boundary between the stirred zone and base material during tensile shear tests. Furthermore, a unique arrangement of the fiber caused by the stirring action was identified by observing the fracture surface using scanning electron microscopy. The study findings clarify the advantages of combining refill FSSW with riveting, providing insights into the potential implementation of this combined process in thermoplastic composites.
Reproducing Timely Subjects: How Abortion Law Calendars Social Reproduction
Authors: Fletcher Ruth
Published: August 2024

Drawing on feminist social reproduction theory and its concern for time spent reproducing the workers of tomorrow, this paper turns to Ireland's new periodic abortion law as a key source of knowledge for social reproduction. I show how law takes different qualitative approaches to measuring reproductive time as it uses a 12 week time limit to distinguish between better and worse reproductive subjects in a context of time poverty. I develop an account of calendaring, with its timelines, punctuations and paces, as a key concept of social reproduction that explains these different legal approaches. Calendars plot reproductive timelines with abstract and concrete moments; they punctuate timelines with different expectations of timeliness, and pace progress with administrative procedures like deadlines and waiting periods. In the process, some become entitled to abortion as timely subjects, others have to make a special case for their exceptional timeliness, and the possibility of being timed out of access threatens all with uneven effects. Periodic abortion law plays a key role in reproducing timely subjects and generating techniques for managing reproductive life cycles in capitalist societies.
Autocratic Legalism and Juridical Veto: Reflections on Politics and the Law in India
Authors: Prakash Amit
Published: August 2024

Much ink has been spilt on the errors and lapses of juridical pronouncements by the higher judiciary in India. Such commentary is valuable for tracing changes in the politico-juridical and social context, as well as, the impact of such errors and lapses on fundamental rights and related laws. However, perhaps, more important are the cases where the judiciary has not spoken, sometimes for years, despite having been petitioned by numerous affected parties and other times under public-interest litigation. The impact of such ‘juridical pocket veto’ is that legal liminality is allowed to operate and thus, a situation of autocratic legalism is produced wherein the action of the executive or legislature is seen as legal in its technicality but in the absence of adequate judicial review, creates an autocratic outcome for the polity at large, which in turn reinforces governmentalisation and undermines the liberal script.
Book review: Namrata Gupta. Women in Science and Technology: Confronting Inequalities
Authors: Nithiya Amirtham S.
Published: August 2024

Namrata Gupta. Women in Science and Technology: Confronting Inequalities. Sage Publications, 2020, 236 pages, ₹1095 (Hardback). ISBN: 978-93-5328-748-1.