bluuebunny/crossref_metadata_2025 huggingface dataset:
L2 acquisition of Spanish dative clitics by English and Dutch learners
Authors: Escobar-Álvarez M. Ángeles
Published: March 2019

This article examines the second language acquisition (SLA) of Spanish dative clitics in clitic doubling (CLD) structures that are closely related to the double object construction (DOC) in English and Dutch. It also addresses the question of how adult English and Dutch speakers learning L2 Spanish in a formal setting develop knowledge and use of the animacy constraint in the target language, which is different from the first language (L1) counterparts. The role of transfer in acquiring new syntactic structures has been taken into account, where dative clitics appear and animate objects are marked by the dative preposition ‘to.’ New findings are obtained on CLD and the Spanish animacy constraint from a grammaticality judgement task (GJT), completed by English and Dutch learners at B1 and B2 CEFR levels. The difficulties learners experienced were not always due to negative L1 transfer, but also related to the complexity of the argument structure where the clitic is inserted. This has clear implications for the teaching of pronominal elements which are closely related to different syntactic configurations in Spanish.
Juliusz Jundziłł, Wzorce i modele wychowania w rodzinie rzymskiej, Wydawnictwo Uczelniane Akademii Bydgoskiej im. Kazimierza Wielkiego, Bydgoszcz 2001, ss. 321
Authors: Apanel Danuta
Published: March 2019

Juliusz Jundziłł, Wzorce i modele wychowania w rodzinie rzymskiej, Wydawnictwo Uczelniane Akademii Bydgoskiej im. Kazimierza Wielkiego, Bydgoszcz 2001, ss. 321
Oblicze ideologiczne szkoły polskiej 1944 -1956, pod red. ks. Edwarda Walewandra, „BAMKA” Studio Komputerowo-Wydawnicze, Lublin 2002, ss. 426
Authors: Posłuszna Małgorzata
Published: March 2019

Oblicze ideologiczne szkoły polskiej 1944 -1956, pod red. ks. Edwarda Walewandra, „BAMKA” Studio Komputerowo-Wydawnicze, Lublin 2002, ss. 426
Dorota Żołądź-Strzelczyk, Wiesław Jamrożek, Studia z dziejów edukacji kobiet na ziemiach polskich, Agencja Wydawniczo- Poligraficzna „Bajt”, Poznań 2001, ss. 152
Authors: Posłuszna Małgorzata
Published: March 2019

Dorota Żołądź-Strzelczyk, Wiesław Jamrożek, Studia z dziejów edukacji kobiet na ziemiach polskich, Agencja Wydawniczo-Poligraficzna „Bajt”, Poznań 2001, ss. 152
Akademia Rakowska
Authors: Żołądź-Strzelczyk Dorota
Published: March 2019

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Editorial
Authors: Angelovska Tanja
Published: March 2019

Abstrakt
Noticing grammar in L2 writing and problem-solving strategies
Authors: Geist Monika
Published: March 2019

Noticing plays an important role for second language acquisition. Since the formulation of the output hypothesis (Swain, 1985), it has been proven that producing output can lead to noticing. Studies on noticing have revealed little focus on grammar, and an in-depth investigation of grammar noticing has not been conducted so far. Studies into problemsolving strategies applied to resolve noticing in writing have provided differing classifications. The current study investigates the noticing of ten young learners (15 to 16 years) of L2 English while performing a writing task, with a special focus on grammar. The problem-solving strategies these learners applied are analyzed. With regard to the linguistic areas, results suggest that verb forms, especially the use of modals, and the choice of prepositions, are the main issues encountered in morphology. In syntax, learners mainly dealt with the length of sentences and the ways of connecting clauses. Learners relied on their intuition and existing knowledge, common sense and rephrasing as grammar problem-solving strategies. These results open a new area of study into noticing grammar and suggest some implications for teaching.
Mosaic trisomy 15 and prenatal genetic counselling: a case of Prader-Willi syndrome due to maternal uniparental disomy
Authors: Aparicio Mar Velilla , Seidel Veronica , Orera Clemente Maria Asunción , Caballero Sylvia Marina , Luna Manuel Sánchez
Published: March 2019

Background

Chromosome abnormalities are a frequent finding in prenatal invasive testing for fetal malformations and/or growth retardation.

Case presentation

We present a case of low level (8%) mosaic trisomy 15 detected on amniocentesis after fetal heart anomalies and IUGR (intrauterine growth retardation) were found on routine scan. Postnatal karyotype confirmed a very low level (2%) mosaicism in the skin but not in blood lymphocytes or in the urine. Methylation specific testing of chromosome 15 showed maternal uniparental disomy and consequently the newborn was diagnosed with Prader-Willi syndrome (PWS).

Conclusions

This case illustrates the need of further genetic testing in all trisomy 15 mosaicisms detected in prenatal invasive testing in order to screen for PWS, a more frequent entity than trisomy 15, altogether providing appropriate genetic counseling and adequate clinical management. The recommendation is applicable to prenatally detected mosaic trisomies of other chromosomes carrying imprinted genes, such as 7, 11 and 14.
Increased irisin versus reduced fibroblast growth factor1 (FGF1) in relation to adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes
Authors: Saber Govand Yaseen , Kasabri Violet , Saleh Mohammad Issa , Suyagh Maysa , Halaseh Lana , Jaber Ruba , Abu-Hassan Hana , Alalawi Sundos
Published: March 2019

Background

Irisin and fibroblast growth factor 1 (FGF1) are intricately involved in metabolic syndrome (MetS) and prediabetes (preDM) pathophysiology. This study aimed to compare and correlate irisin and FGF1 plasma levels, adiposity, atherogenicity and hematological indices in 29 normoglycemic MetS and 30 newly diagnosed drug naive prediabetic (PreDM) MetS patients vs. 29 lean and normoglycemic controls.

Materials and methods

Irisin and FGF1 plasma levels were measured using colorimetric assays. Intergroup comparisons were conducted by analysis of variance (ANOVA). Spearman’s rank correlation was also examined.

Results

The mean circulating irisin levels (ng/mL) were significantly higher in the normoglycemic (but not prediabetic) MetS group (p < 0.01), while the mean circulating FGF1 levels (pg/mL) were markedly lower in the prediabetic (but not normoglycemic) MetS group (p < 0.05). Of note unlike FGF1, irisin in the MetS (both normoglycemic and prediabetic;N=59) groups correlated significantly and positively with each of waist circumference (WC), hip circumference (HC), body mass index (BMI), body adiposity index (BAI) and high-density lipoprotein-cholesterol (HDL-C) but not the non-HDL-C. Distinctively MetS-irisin negatively associated with the non-HDL-C/HDL-C ratio, total cholesterol (TC)/HDL-C ratio and the low-density lipoprotein-cholesterol (LDL-C)/HDL-C ratio, but positively with the red cell distribution width (RDW). In the same pool of 59 MetS reruits; Neither biomarker had a relationship with the visceral adiposity index (VAI), the lipid accumulation product (LAP), the conicity index (CI), the waist-hip ratio (WHR), the waist-to-height ratio (WHtR), the blood ratios or the atherogenicity index of plasma (AIP).

Conclusions

As any potential molecular crosstalk of irisin and FGF1 in MetS or its related dysregularities cannot be ruled out; Conversely the utility of irisin and FGF1 as surrogate prognostic biomarkers and putative pharmacotherapeutic targets in the predtion/prevention/management of diabetes and MetS is strongly suggested.
Growth Kinetics of CoB–Co2B Layers Using the Powder-Pack Boriding Process Assisted by a Direct Current Field
Authors: Campos-Silva I. , Franco-Raudales O. , Meda-Campaña J. A. , Espino-Cortés F. P. , Acosta-Pavón J. C.
Published: March 2019

New results about the growth kinetics of CoB–Co2B layers developed at the surface of CoCrMo alloy using the powder-pack boriding process assisted by a direct current field (PBDCF) were estimated in this work. The PBDCF was conducted at temperatures of 1048 – 1148 K with different exposure times for each temperature, whereas the growth kinetics of the cobalt boride layers was modelled using a system of two differential equations. In addition, indentation properties such as hardness, Young’s modulus and residual stresses were estimated along the depth of the borided CoCrMo surface. The growth kinetics of the cobalt boride layers developed by PBDCF indicated that thicker boride layers were formed on the material’s surface which was in contact to the current field at the anode, in contrast to the surface exposed at the cathode. The kinetics of cobalt boride layers were compared with those obtained by conventional powder-pack boriding process.
A Constitutive Equation for Predicting Elevated Temperature Flow Behavior of BFe10-1-2 Cupronickel Alloy through Double Multiple Nonlinear Regression
Authors: Cai Jun , Wang Meng , Shi Jiamin , Wang Kuaishe , Wang Wen
Published: March 2019

Constitutive analysis for elevated temperature flow behavior of BFe10-1-2 alloy was carried out by using experimental stress–strain data from isothermal hot compression tests on a Gleeble-3800 thermo-mechanical simulator, in a wide of temperature range of 1,023–1,273 K, and strain rate range of 0.001–10 s−1. A constitutive equation based on double multiple nonlinear regression (DMNR) was proposed considering the independent effects of strain, strain rate, temperature and their interrelation. The predicted flow stress data obtained from the developed equation based on DMNR was compared with the experimental data. Correlation coefficient (R), average absolute relative error (AARE) and relative errors were introduced to verify the validity of the developed constitutive equation. The results showed that the developed constitutive equation based on DMNR could predict flow stress of BFe10-1-2 alloy with good correlation and generalization.
Lightbeam Configuration Method and Interference Elimination Resource Scheduling for Indoor Multibeam VLC Networks
Authors: Tran Cong-Nam , Nguyen Nam-Hoang , Hoang Trong-Minh
Published: March 2019

Visible light communications (VLC) is considered as an alternative communications technology for providing indoor wireless services. VLC systems are expected to offer high data transmission rate and seamless coverage. In order to achieve these requirements, VLC systems utilizing multi-lightbeam access points (multibeam VLC-AP) for downlink transmission have been proposed recently. In this paper, we present a lightbeam configuration method and an interference elimination resource scheduling mechanism (IERS) for indoor multibeam multi-access point VLC systems. The proposed lightbeam configuration method ensures seamless connectivity between user equipment and VLC-AP. The proposed IERS mechanism consists of a beam assignment algorithm and a resource allocation algorithm for eliminating co-channel interference as well as improving system performance. Performance results obtained by computer simulation indicate that there are significant improvements in terms of downlink signal to interference plus noise ratio, user throughput and packet delay when the proposed IERS mechanism is deployed.
Investigating the presence of human anti-mouse antibodies (HAMA) in the blood of laboratory animal care workers
Authors: Mohammadi Mohammad Mahdi , Bozorgi Shahram
Published: March 2019

Background

In the present study, the researchers evaluated the presence of human anti-mouse antibodies (HAMA) in a normal population and laboratory animal care providers for the first time in the world. Also, the cause of HAMA incidence in the human body through a close contact with mice was identified.

Methods

The study population consisted of 40 laboratory animal care providers aged between 24 and 57 years with a close contact with mice (e.g. taking care of mice, feeding mice, etc.) and 40 individuals of the same age as the above group with no contact with mice. HAMA was measured in both the case and control groups using sandwich enzyme-linked immunosorbent assay (ELISA) method. Data were analyzed using SPSS 18. Univariate and multivariate linear regression and independent t-test were used. The significance of results was measured based on p < 0.05.

Results

The present study revealed that the animal care providers had (p = 000) a higher titer of HAMA (4.95 ng/mL) in their blood than the control group (1.67 ng/mL). Also, the individuals in the case group (exposed to mice) were more allergic (43.6%) than those in the control group (15%) (p = 0.003).

Conclusions

The results of this study revealed that exposure to mice in laboratory care centers can cause production of HAMA in the human body but its titer is possibly lower in Iranian working staff than those in the other parts of the world.
Emissions Trading Hybrids: The Case of the EU ETS
Authors: Woerdman Edwin , Nentjes Andries
Published: March 2019

We argue that the European Union Emissions Trading System (EU ETS) has evolved into a hybrid of two design variants, allowance trading (cap-and-trade) and credit trading (performance standard rate trading), with an added feature of industry support to minimize carbon leakage. In particular the current rules tying free allowances to production capacity expansion, plant closure and capacity use have transformed the efficient cap-and-trade program that stood at the origins of the EU ETS into a system that even surpasses credit trading in paying hidden product subsidies to firms. This combination of rules encourages an inefficiently high level of investment in production capacity and an inefficiently high output in industries exposed to international competition. The result is a sub-optimal EU Emissions Trading ‘Hybrid’ (which we therefore label as ‘EU ETH’).
Is the Simple Price Premium that Simple?
Authors: Shi Yuying
Published: March 2019

Brand equity has been a perennial topic in marketing. Among all types of measures, price premium is widely accepted due to its simple yet efficient characteristics. However, there is some disagreement regarding whether this measure captures enough facets of brand equity and whether price premium is an appropriate measure to reflect the market position of a brand. With current technique developments, more sophisticated brand equity measures have been developed. A natural question arises as to whether more sophisticated measures are better than price premium. Using large-scale national scanner data covering 47 major U.S. markets, we employ the aggregated demand model to estimate a complex brand equity measure and compare it with price premium. Our results suggest that the simple price premium is consistent with the complex measure under certain conditions. We provide managers with suggestions regarding choosing the most appropriate brand equity measures to signify their brands’ values.
God of the Nations: Daniel, Satan, and the Temptation of Jesus in Luke
Authors: Ferda Tucker S.
Published: March 2019

In both Matthew and Luke, Satan offers Jesus “all the kingdoms of the world” in exchange for his obeisance. Only in Luke, however, does Satan make an intriguing claim about his “authority” over the kingdoms and his prerogative to “give” such “to whomever he wishes” (4:6). Richard Hays lamented in his recent Echoes of Scripture in the Gospels that this unique detail has not been given thorough attention in exegetical studies of Luke-Acts. This study takes up the question of Satan’s claim in detail and suggests that Satan’s words are informed by a phrase that appears multiple times in the book of Daniel: “the Most High is sovereign over the kingdom of mortals and gives it to whomever he wishes.” This intertextuality is important for the larger narrative of Luke-Acts in two respects. First, it presses the question of whether, from the perspective of the larger narrative, Satan’s claim is truthful. The article concludes that an answer to that question is not immediately clear; the narrative permits varied readings. Secondly, it is argued that the Danielic background of Luke 4:6 intensifies the Christological drama of the narrative. Jesus is here tested with what is legitimately his as Daniel’s “Son of Man,” and we soon find that he will receive such not from the hand of Satan but from obedience to God.
Verstehen und Glauben im Johannesevangelium: Ein alternativer Übersetzungsvorschlag für Joh 5,37–40
Authors: Förster Hans
Published: March 2019

John 5:37–40 concerns a central problem of the Gospel of John: the relationship between understanding and faith. Translational choices appear to have had a strong influence on the interpretation of this passage. This contribution discusses alternative options for translating the passage. This alternative understanding of the passage allows the author to argue in favour of close links between John 5:37–40 and Jewish tradition.
Interprofessional care improves health-related well-being and reduces medical costs for chronic pain patients
Authors: Seitz Tamara , Stastka Kurt , Schiffinger Michael , Rui Turk Bela , Löffler-Stastka Henriette
Published: March 2019

This study evaluated whether patients with somatic symptom disorder, expressing chronic pain that could not be attributed to a medical condition, would benefit from an 8-week inpatient residence at a psychiatric ward. In the 1-year follow-up after termination the authors examined the extent to which the integrated treatment decreased patient costs. A total of 106 patients participated in the follow-up and reported a significant improvement in their general health (Cohen's d = 1.5–2.21), a decrease in impairment due to pain (d = 2.24), and a decrease in symptom severity (d = 1.29). They took fewer medications and sick days, reported fewer hospital stays and medical examinations, and consulted and changed physicians and outpatient clinics less often (d = 0.55–1.1). The average cost per patient was cut in half, down to є 80,000/$96,000 per year. From a clinical standpoint, group analysis that focused on aggression was the most effective intervention.
Internet of Things: uma investigação do conhecimento científico em artigos acadêmicos de 2008 a 2017
Authors: Souto Bolzan Medeiros Flaviani , Colpo Iliane , Schneider Vanessa Andréia , Stefan de Carvalho Patrícia
Published: March 2019

É inegável o crescente interesse e novas discussões que surgem a todo o momento em torno de conceitos que prometem modificar o futuro. Dentre eles, destaca-se a Internet of Things (IoT) – Internet das Coisas – que possibilita que objetos físicos sejam tanto monitorados como controlados de forma remota via internet. É um novo modo de interação que brevemente vai mudar a rotina dos indivíduos em casa, no trabalho e/ou nas indústrias, inclusive, objetos inteligentes já vêm sendo adotados por alguns setores do mercado, como no agronegócio, na saúde etc. Deste modo, em termos acadêmicos, o objetivo deste trabalho foi mapear, a partir da bibliometria, o conhecimento científico acerca da Internet of Things nos artigos indexados na Web of Science entre 2008 a 2017. Para isso, caracterizando-se como um estudo qualitativo-quantitativo e do tipo descritivo, se apresenta um diagnóstico atual das publicações com evidência nos dados por ano, áreas, fontes, nacionalidade, instituições e idiomas, como também, principais autores e os hot topics (tópicos quentes) relacionados com a IoT. Os resultados obtidos reforçam a multidisciplinaridade do tema e a sua relevância em um mundo repleto de novas tecnologias que facilitam as atividades do cotidiano com extrema rapidez e agilidade por meio da Internet.
UM ESTUDO COMPARATIVO ENTRE GERAÇÕES X, Y E Z EM RELAÇÃO AS NOVAS TECNOLOGIAS E COM O E-COMMERCE
Authors: Krampe Márcia Estela Daltoé da Silva , Brambilla Flávio Régio , Angnes Derli Luís
Published: March 2019

O estudo tem como objetivo comparar as gerações X, Y e Z em relação a: satisfação nas compras no e-commerce, qualidade das lojas virtuais, importância das tecnologias digitais e o seu comportamento multitarefa em ambientes on-line. Para tal, desenvolveu-se uma revisão teórica sobre todos os assuntos elencados e foram então desenvolvidas duas etapas de coleta de dados, sendo a primeira uma pesquisa exploratória qualitativa e a segunda uma pesquisa descritiva quantitativa. Na primeira etapa, foram realizadas entrevistas em profundidade e analisadas através da técnica de análise de conteúdo. Na segunda etapa, aplicou-se uma survey on-line, alcançando uma amostra de 251 respondentes válidos. Dentre os principais resultados obtidos, foi identificando diferenças em relação à satisfação, na percepção de qualidade no e-commerce e no envolvimento em relação as tecnologias digitais abrangendo as três gerações. Somente no comportamento multitarefas não foram encontradas diferenças estatisticamente significativas entre gerações.PALAVRAS-CHAVE: E-commerce; Tecnologias digitais; Multitarefas; Gerações X, Y e Z.
THE TRACEABILITY OF MATERIALS IN A BRAZILIAN PUBLIC HOSPITAL
Authors: Santos Mateus , Reis Augusto Cunha , Dias Ana Claudia , Senna Pedro , Pizetta Luciane Machado
Published: March 2019

In Brazil all citizens has free access to public health. Currently the number of people using this service presented an extraordinary growth due to the economic crisis taking in the country that culminated in the incapacity of them in to maintain health insurance.  At Rio de Janeiro there is a constant concern regarding the quality of the services offered to the population. In this way, a case of study was elaborated in a federal hospital, located at Rio de Janeiro, with the purpose to present the problems faced by the hospital related to the traceability and management of materials in warehouse. It believes that any economy resulting from the improvements of warehouse management should provide a gain to the services offered to the population. The result of the study was the elaboration of a proposal to be implemented by the hospital, in order to mitigate problems faced by them that impacts the reduction of costs and improvement of the services.
Mentally tiring work and type 2 diabetes in women: a 22-year follow-up study
Authors: Fagherazzi Guy , Gusto Gaelle , El Fatouhi Douae , Mancini Francesca Romana , Balkau Beverley , Boutron-Ruault Marie-Christine , Bonnet Fabrice
Published: March 2019

Hypothesis

Previous work suggested no or inconsistent associations between components of work-related stress and type 2 diabetes risk, but suggested sex-specific differences should be further investigated, as women potentially had higher risks.

Methods

We analyzed data from 73 517 women, mostly teachers, from the E3N cohort study followed for 22 years (1992–2014), to study the association between mentally tiring work, used as a proxy of job demands, and type 2 diabetes risk. Univariate and multivariable Cox regression models were used to estimate hazard ratios and 95% confidence intervals.

Results

A total of 4187 incident cases of type 2 diabetes cases were observed. There was a higher type 2 diabetes risk for women with a ‘Very mentally tiring work’ when compared to women with ‘Little or not mentally tiring work’ (HR = 1.21 (1.09–1.35)). This association was independent of unhealthy lifestyle and traditional metabolic factors. An interaction between mentally tiring work and BMI was detected (P < 0.0001), with a stronger association being observed in non-overweight women, HR = 1.26 (1.08–1.47) vs HR = 1.14 (0.98, 1.32), in overweight women.

Conclusions

We observed an increased risk of type 2 diabetes associated with mentally tiring work, used as a proxy of job demands. These observational results suggest the importance of taking into consideration the potential long-term metabolic impact of work-related stress for women working in a demanding environment. Increased support for such women should be investigated in intervention studies.
PIK3CA mutations in ductal carcinoma in situ and adjacent invasive breast cancer
Authors: Agahozo Marie Colombe , Sieuwerts Anieta M , Doebar S Charlane , Verhoef Esther I , Beaufort Corine M , Ruigrok-Ritstier Kirsten , de Weerd Vanja , Sleddens Hein F B M , Dinjens Winand N M , Martens John W M , van Deurzen Carolien H M
Published: March 2019

PIK3CA is one of the most frequently mutated genes in invasive breast cancer (IBC). These mutations are generally associated with hyper-activation of the phosphatidylinositol 3-kinase signaling pathway, which involves increased phosphorylation of AKT (p-AKT). This pathway is negatively regulated by the tumor suppressor PTEN. Data are limited regarding the variant allele frequency (VAF) of PIK3CA, PTEN and p-AKT expression during various stages of breast carcinogenesis. Therefore, the aim of this study was to gain insight into PIK3CA VAF and associated PTEN and p-AKT expression during the progression from ductal carcinomain situ(DCIS) to IBC. We isolated DNA from DCIS tissue, synchronous IBC and metastasis when present. These samples were pre-screened for PIK3CA hotspot mutations using the SNaPshot assay and, if positive, validated and quantified by digital PCR. PTEN and p-AKT expression was evaluated by immunohistochemistry using the Histo-score (H-score). Differences in PIK3CA VAF, PTEN and p-AKT H-scores between DCIS and IBC were analyzed. PIK3CA mutations were detected in 17 out of 73 DCIS samples, 16 out of 73 IBC samples and 3 out of 23 lymph node metastasis. We detected a significantly higher VAF of PIK3CA in the DCIS component compared to the adjacent IBC component (P = 0.007). The expression of PTEN was significantly higher in DCIS compared to the IBC component in cases with a wild-type (WT) PIK3CA status (P = 0.007), while it remained similar in both components when PIK3CA was mutated. There was no difference in p-AKT expression between DCIS and the IBC component. In conclusion, our data suggest that PIK3CA mutations could be essential specifically in early stages of breast carcinogenesis. In addition, these mutations do not co-occur with PTEN expression during DCIS progression to IBC in the majority of patients. These results may contribute to further unraveling the process of breast carcinogenesis, and this could aid in the development of patient-specific treatment.
Prevalencia del bullying en México: un meta-análisis del bullying tradicional y cyberbullying
Authors: Vega-Cauich Julio Isaac
Published: March 2019

Objetivo: Sintetizar los diagnósticos de bullying en México para estimar la prevalencia de víctimas y agresores, tanto en su modalidad cara a cara como virtual. Método: Se realizó un meta-análisis de la prevalencia con 27 investigaciones realizadas en México con un modelo de efectos aleatorios, y se exploraron sus moderadores a través de una meta-regresión. Resultado: La prevalencia osciló entre el 19 y 21 % para cibervictimización, victimización y agresión cara a cara, y de un 11 % para la ciberagresión. Las variables que moderaron la estimación de la prevalencia fueron la presencia de una definición en el instrumento y el número de ítems. Ningún estudio utilizó instrumentos que evaluaran el componente de desbalance de poder del bullying, por lo que es probable que los estudios hayan evaluado el concepto de victimización entre pares. Conclusión: Uno de cada cinco estudiantes mexicanos recibe o realiza bullying o cyberbyllying. Se proponen recomendaciones metodológicas para futuras investigaciones.
Los niveles de actuación en las relaciones de trabajo y la formación de contratos psicológicos
Authors: Rentería Pérez Erico , Vesga Rodríguez Juan Javier
Published: March 2019

El contrato psicológico es un concepto clave en la comprensión de las relaciones de trabajo en la actualidad. Sin embargo, dada la pluralidad y composición de éstas por las dinámicas empresariales, la concepción sobre la formación de contratos psicológicos se hace a la vez compleja. En este sentido, se propone en este artículo teórico, el análisis de la estructuración de las relaciones de trabajo a través de diversos niveles de actuación, como encuadre para la comprensión de la formación de contratos psicológicos. Esta perspectiva permite obtener una visión más amplia y completa de la manera como funcionan las relaciones de trabajo, con el propósito de adoptar una mirada multidimensional del contrato psicológico, para poder entender que éste no se reduce a una relación diádica, sino que en su formación intervienen otros aspectos provenientes de los diversos niveles en que se configuran las relaciones de trabajo en las organizaciones.
Cine, poder e historia: la representación y construcción social del indígena en el cine ficción venezolano durante la década de los años 80
Authors: Rodríguez Velásquez Fidel
Published: March 2019

El presente artículo analiza desde una perspectiva histórico-antropológica al cine como vehículo en el que se relacionan de forma directa o indirecta el poder (estatal) y la historia (historia oficial) en la representación del indígena venezolano durante la década de los años 80, utilizando la noción de historia de Gaskell (1996) quien la entiende como “el discurso elaborado por los historiadores y no el pasado”, y lo señalado por Iglesias (2013) cuando esboza que “el cine tiene un papel político crucial como mediador del imaginario colectivo a la hora de construir identidades”, para ello se realizó un análisis crítico del discurso que sobre los pueblos indígenas venezolanos están contenidos en las películas: Caballo Salvage (1981), Orinoko Nuevo Mundo (1984), Ya-koo (1985), Cubagua (1987) y Amérika, terra incógnita (1988) a la luz de las ideas que de estos se impulsaron desde el Estado Venezolano.
Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing
Authors: Nicholls Peter K , Bellott Daniel W , Cho Ting-Jan , Pyntikova Tatyana , Page David C
Published: March 2019

The introduction of foreign DNA into cells and organisms has facilitated much of modern biological research, and it promises to become equally important in clinical practice. Locating sites of foreign DNA incorporation in mammalian genomes has proven burdensome, so the genomic location of most transgenes remains unknown. To address this challenge, we applied nanopore sequencing in search of the site of integration of Tg(Pou5f1-EGFP)2Mnn (also known as Oct4:EGFP), a widely used fluorescent reporter in mouse germ line research. Using this nanopore-based approach, we identified the site of Oct4:EGFP transgene integration near the telomere of Chromosome 9. This methodology simultaneously yielded an estimate of transgene copy number, provided direct evidence of transgene inversions, revealed contaminating E. coli genomic DNA within the transgene array, validated the integrity of neighboring genes, and enabled definitive genotyping. We suggest that such an approach provides a rapid, cost-effective method for identifying and analyzing transgene integration sites.
Cerebral Embolic Protection in TAVI: Friend or Foe
Authors: Teitelbaum Michael , Kotronias Rafail A , Sposato Luciano A , Bagur Rodrigo
Published: March 2019

Cerebrovascular accidents including stroke or transient ischaemic attack are one of the most feared complications after transcatheter aortic valve implantation. Transcatheter aortic valve implantation procedures have been consistently associated with silent ischaemic cerebral embolism as assessed by diffusion-weighted MRI. To reduce the risk of cerebrovascular accidents and silent emboli, cerebral embolic protection devices were developed with the aim of preventing procedural debris reaching the cerebral vasculature. The authors summarise the available data regarding cerebral embolic protection devices and its clinical significance.
Aconcagüinos en la historia de Chile: carta de Pedro Antonio Ramírez a Benjamín Vicuña Mackenna sobre el motín popular de San Felipe del 14 de octubre de 1851
Authors: Castro Valdebenito Hugo
Published: March 2019

La presente transcripción documental pone en valor histórico una carta privada enviada por un participante de las insurrecciones y alzamientos populares registrados en la ciudad de San Felipe durante la denominada Revolución o Guerra Civil chilena de 1851. La misiva presentada y transcrita se constituye como un ejercicio de memoria histórica escriturada, la cual fue solicitada por el político, escritor e historiador chileno Benjamín Vicuña Mackenna a Pedro Antonio Ramírez con el objeto de nutrir la investigación histórica que dio origen a la obra Historia de la jornada del 20 de abril de 1851. El documento transcrito contrapone una versión alterna al discurso oficial historiográfico en cuanto a la narración de los acontecimientos armados ocurridos el 14 de octubre de 1851 en la provincia de Aconcagua. El texto permite identificar, especialmente, la participación del pueblo sanfelipeño —vecinos, artesanos milicias y el pueblo en general— en las acciones revolucionarias organizadas y lideradas por la oposición liberal aprovechando el descontento local que se había gestado en la provincia frente al autoritario centralismo capitalino.
Estado y política en el interior argentino: oficialismo y oposición durante el peronismo histórico
Authors: Camaño Semprini Rebeca Raquel
Published: March 2019

El presente trabajo tiene por objetivos comprender e interpretar los cambios y continuidades en la dinámica relacional entre el oficialismo peronista a cargo del Gobierno municipal y los partidos de la oposición entre 1946 y 1955. Al mismo tiempo, la investigación pretende analizar el tipo de relaciones entabladas entre el Estado municipal y el provincial. Al respecto cabe apuntar que dos procesos —inaugurados casi simultáneamente con el surgimiento del peronismo— influyeron fuertemente sobre las características que asumieron sus relaciones con los partidos opositores. Por una parte, el creciente cercenamiento del régimen de autonomía municipal; y por la otra, la estrecha vinculación entre el peronismo y la esfera estatal. Para llevar a cabo estos objetivos se recurrió a una metodología cualitativa, basada en la lectura y análisis de diversas fuentes (diarios locales y provinciales, documentación oficial y escritos de dirigentes peronistas). La información recopilada no fue abordada en forma aislada sino debidamente enmarcada en los procesos desarrollados a nivel provincial y nacional. La articulación de los niveles macro y micro nos permite estudiar con mayor grado de detalle los procesos políticos examinadosy complementar y matizar los estudios sobre el peronismo enfocados desde perspectivas más generales.
Aspectos metodológicos para um estudo comparativo: cultura material e arquivos notariais no Brasil e na Colômbia
Authors: Carreño-Tarazona Clara Inés
Published: March 2019

Este artículo pretende responder a la pregunta sobre cuál es la importancia del método comparativo para estudiar la vida económica-material encontrada en los archivos notariales de Brasil y Colombia. A partir del concepto de cultura material y de la aplicación del método comparativo a los registros notariales de los archivos históricos de Franca-Brasil y Bucaramanga-Colombia, se propuso problematizar sobre la manera como la producción de instrumentos notariales permitió la materialización de ciertas actividades económicas cotidianas, logrando identificar importantes relaciones e intereses entre dos grupos de familias y sus negocios locales y regionales, en el desarrollo de los dos países durante la segunda mitad del siglo XIX. Los resultados de la confrontación de dichas fuentes son un aporte útil para promover la importancia de los estudios comparativos con otras regiones en el contexto de la reconstrucción de una historia global.
La medicina social y preventiva en Argentina desde un enfoque biográfico. La trayectoria de Francisco Martone
Authors: Ramacciotti Karina , Rayez Federico
Published: March 2019

En el presente artículo nos proponemos analizar la trayectoria profesional del médico argentino Francisco José Martone (1909-1998) y explorar las contribuciones de este a una medicina preventiva y social. El trabajo ha sido realizado desde una metodología cualitativa de análisis documental y desde un enfoque biográfico en diálogo con una corriente de investigaciones que vienen analizando las carreras profesionales de ciertos médicos argentinos y latinoamericanos. Para cumplir nuestros objetivos apelamos a distintos tipos de fuentes: libros y artículos publicados por Martone, documentación oficial, su legajo administrativo en la Universidad y otro tipo de materiales. De acuerdo con estas fuentes, pudimos reconstruir la trayectoria universitaria y profesional de Martone, su paso por distintas comisiones legislativas en el Congreso Nacional, su participación en la gestión peronista y su producción teórica relativa a la fundamentación de la medicina social y la profesionalización de la enfermería. Estos aportes, así como su biografía, nos permiten un acercamiento íntimo a los avatares del campo de la salud pública argentina en el período que va desde los años treinta hasta los ochenta del siglo XX.
Impregnation as a method for preservation of relics used by the Christian Church
Authors: Tomov N. , Dimitrov N. , Atanasova D. , Dzhanozov J. (Yanko)
Published: March 2019

Relics are a special type of human body remains, which are venerated by the faithful due to the prominence the person had achieved during lifetime. Even if no such claims for incorruptibility are made, body relics have to be preserved in some fashion, in order to allow for their long-term viewing and veneration. The present report summarizes the available data regarding the impregnation as a method for body preservation, used by the Christian Church to conserve body relics. Impregnation is a widely used method, both by the Orthodox as well as by the Roman Catholic Church. It is known that bodies are treated with different protective mixtures on variable intervals after death. Public worship historically involved pouring of oil over relics. Moreover, small tissue fragments are embedded in wax blocks or are sealed with a mixture of molten wax and other resins. All of those methods are in fact impregnation with compounds with high molecular mass as a final stage of a preservation procedure. This impregnation of a tissue already reached some degree of dehydration or other preservation ensures longevity and protection of the relics by greatly slowing down the natural processes of decomposition and disintegration.
A tudás útja: A másolattól az eredetiig a Budapest Székesfovárosi iparrajziskola (1886–1945) egykori gipszgyűjteményének kutatása
Authors: Katona Júlia
Published: March 2019

The paper presents the conception and art historical conclusions of the exhibition entitled Knowledge in Plaster Casts. The former cast collection of the Budapest Metropolitan Industrial Drawing School (1886–1945) held in FUGA Budapest Center of Architecture on 4–25 October 2017.

The three groups of exhibits comprised original 19–20th century plaster casts, 18–19th century drawings from casts, and reproduced photos from the catalogue of the casting workshop of the Hungarian National Royal Higher School of Architecture dated 1904. As the price list illustrations revealed, late 19th–early 20th century cast collections for the purpose of education were visual encyclopaedias of the educational and cultural ideals of the age. Thematically, the replicas of pattern and sculpture conveyed a broad scale of mythological knowledge, culture historical information via notable figures of literature and history, as well as botanic, anatomical and geometric knowledge. The compilation of a cast collection required broad historical, culture historical and professional expertise, and the casting workshops and the cast catalogues they published mediated this common knowledge.

The exhibition and the preceding elaboration of the collection provided further art historical conclusions, of which the paper embarks on the relationship between original and copy apropos a plaster paraphrase of a 12th century stone carving from Saint Denis.
Is Cytoreductive Nephrectomy Still a Standard of Care in Metastatic Renal Cell Carcinoma?
Authors: Renner Alex , Samtani Suraj , Marín Arnaldo , Burotto Mauricio
Published: March 2019

Cytoreductive nephrectomy has been an integral part of management in metastatic renal cell carcinoma for patients with good performance status, based on the benefit shown by prospective trials in the interferon era and retrospective trials in the targeted therapies era. Clinical Trial to Assess the Importance of Nephrectomy (CARMENA), the first prospective phase III trial comparing a targeted agent alone (sunitinib) versus nephrectomy plus sunitinib, has been recently published, showing non-inferiority for the nephrectomy-sparing arm. In this article, we discuss the impact of nephrectomy including its immune-mediated effects, surgical morbidity and mortality, and the clinical data supporting the indications of nephrectomy in order to analyze the CARMENA trial in context, with the aim to identify optimal strategies for different patient populations in the metastatic setting.
Lean Start-Up as a Strategy for the Development and Management of Dynamic Entrepreneurships
Authors: Araya Castillo Luis
Published: March 2019

In recent years, several methodologies have emerged for the development and management of enterprises and new enterprises. One of the methodologies with the greatest impact in the global entrepreneurial community in the creation of the launch, developed by Erick Ries in 2008. This is based on the principles of scientific method and artistic creation. In this scenario, the objective of the present investigation is to analyze the methodology of Lean Initiation as a process of management and development of enterprises, mainly states as dynamic. In addition, a brief comparative analysis with other similar methodologies will be carried out in such a way that it is possible to objectively justify the use of this method. ResumenEn los últimos años han surgido una serie de metodologías para el desarrollo y la gestión de emprendimientos y nuevas empresas. Una de las metodologías con mayor impacto en la comunidad emprendedora global es la del Lean Start-up, desarrollada por Erick Ries en el año 2008.Ésta se fundamenta en los principios del método científico y de la creación artística. En este escenario, el objetivo de la presente investigación es el de analizar la metodología del Lean Startup como proceso de gestión y desarrollo de emprendimientos, principalmente aquellos clasificados como dinámicos.  Además, se realizará un breve análisis comparativo con otras metodologías similares de forma tal que sea posible justificar objetivamente la utilización de este método. ResumoNos últimos anos, vários métodos surgiram para o desenvolvimento e gestão de empresas e novas empresas. Um dos métodos com maior impacto na comunidade empreendedora global na criação do lançamento, desenvolvido por Erick Ries em 2008. Isto é baseado nos princípios do método científico e da criação artística. Neste cenário, o objetivo da presente investigação é analisar a metodologia de Lean Initiation como um processo de gestão e desenvolvimento de empresas, principalmente estados como dinâmicos. Além disso, uma análise comparativa com outras metodologias similares será realizada de tal forma que seja possível justificar objetivamente o uso desse método.
Information Hygiene: General Theoretical Assessment of the Problem
Authors: Molodtsova Irina , Maksimova Elena , Slivina Lyudmila
Published: March 2019

The use of information technology in all spheres of activity raises the problem of hygienic regulation of information loads for the population, especially children. The authors describe the negative effects of information on children and adolescents. Due to this fact, there is a need to create secure information environment. It is necessary to list some principles of information hygiene: complexity, focus, socio-political activity, science, accessibility, integrity, consistency, qualitative and quantitative approach in data analysis, differentiated and individual approach to the child, continuity of protection, ease of use of protective methods and tools, reasonable sufficiency, flexibility of management and application, openness of algorithms and protection mechanisms, validity of access, personal responsibility, etc.

Thus, the development of the information society involves developing information hygiene to prevent the negative impact of information load from different sources on the health of the population, especially children. It is necessary to calculate the individual risks of different types of information and to predict their consequences for the health of adolescents, followed by the development of a program of preventive and recreational work with them. To this end, Russia has the scientific potential and modern technologies in the field of hygiene, protection and promotion of the health of children, adolescents and young people.
Leptomeningeal Carcinomatosis in Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature
Authors: Naydenov Alipi V. , Taylor Lynne P.
Published: March 2019

Leptomeningeal disease is a rare complication of chronic lymphocytic leukemia (CLL). We report a case of leptomeningeal disease in CLL with a complete clinical response and clearance of cerebral spinal fluid (CSF) after treatment with ibrutinib and intrathecal rituximab. In a comprehensive review of the published literature since 1976, we found 136 cases of CLL with leptomeningeal spread. We found that leptomeningeal disease in patients with CLL responds favorably to treatment in most cases and is associated with longer overall survival than is expected for other cancers. Clearance of CSF is associated with improved survival. Treatment with rituximab and ibrutinib is more frequently associated with complete response compared with older agents.

Implications for Practice

The incidence of leptomeningeal CLL is more common than previously described and can be recognized by attention to certain symptoms and signs. This case presentation and literature review reveals that, in many cases, leptomeningeal lymphomatosis is reversible with the use of rituximab and ibrutinib. The authors show a survival benefit associated with treating to cerebral spinal fluid (CSF) clearance by cytology and compare outcomes with various treatment strategies, focusing on novel agents. Now that there is effective therapy for leptomeningeal lymphoma in CLL, the importance for oncologists to recognize this neurologic complication has become clear.
Green synthesis of glycerol monostearate-modified cationic waterborne polyurethane
Authors: Sultana Mst Zakia , Mahmud Sakil , Pervez Md Nahid , Hasan K M Faridul , Heng Quan
Published: March 2019

In this research, a novel class of glycerol monostearate (GMS)-modified cationic waterborne polyurethane (CWPU) dispersions has been successfully synthesized by using isophorone diisocyanate as a raw material under the action of a catalyst and cosolvent. The CWPU dispersion has been characterized by Fourier transform infrared spectroscopy, and the effect of GMS on the particle size distribution, solid content, surface tension, viscosity and stability was carefully investigated as well. Then, a new type of transparent and high-performance film was prepared by casting the CWPU dispersion onto a glass substrate. The film performances were studied by scanning electron microscopy, dynamic light scattering, X-ray diffraction, thermogravimetric analysis and measurements of mechanical properties, water contact angle and weight gained in different solvents (water, acid and alkali). The resulting CWPU films have an adequate level of transparency and sufficient folding flexibility, are thermally stable up to 550°C and exhibit high tensile stress–strain behavior. This work proposes a new route for utilizing value-added CWPU with superior properties that will help maintain balance in the sustainable chemical industry.