bluuebunny/crossref_metadata_2025 huggingface dataset:
CircHIPK3 promotes thyroid cancer progression via miR-338-3p/RAB23 axis
Authors: Shu Taipengfei , Wang Jing , Lu Jixuan , Sun Lijie , Wang Shurui , Han Cong , Zhang Siyue , Zhan Xiaorong , Jiang Jun
Published: January 2024

Background: Reports have suggested circular RNAs (circRNAs) have vital functions in cancer biology. Herein, we aim to explore the function of circHIPK3 in the mechanism of thyroid cancer (TC).
Methods: The levels of circHIPK3 in TC cells and 10 paired samples were studied by qRT-PCR. Next, the effect of circHIPK3 on TC cell activities was observed by CCK-8 and Transwell assays. Subsequently, the downstream targets of circHIPK3 in TC were predicted and confirmed by dual-luciferase reporter assay.
Results: CircHIPK3 had a high expression in TC cells and samples, mainly in cell cytoplasm, and its downregulation significantly inhibits cell growth and metastasis. Then, we predicted the downstream targets of circHIPK3 in thyroid cancer were miR-338-3p and RAB23, which was confirmed by experiments later.
Conclusion: We discover that circHIPK3 can promote TC by down-regulating miR-338-3p and up-regulating RAB23, providing new ideas into the mechanism of circRNA roles in TC and demonstrating that circHIPK3 can be a promising indicator or target for TC diagnosis and treatment.
Interpretable machine learning-derived nomogram model for early detection of persistent diarrhea in Salmonella typhimurium enteritis: A propensity score matching based case-control study
Authors: Jin Longteng , Huang Yucheng , Xi Jianan , Zhan Lu , Jin Haojie , Chen Yiping , Chu Maoping
Published: January 2024

Salmonella typhimuriuminfection is a considerable global health concern, particularly in children, where it often leads to persistent diarrhea. This condition can result in severe health complicationsincluding malnutrition and cognitive impairment. A retrospective case-control study was carried out involving 627 children diagnosed with S. typhimuriumenteritis. The children were admitted to the Second Affiliated Hospital of Wenzhou Medical University between January 2010 and December 2022. Propensity score matching was used to explore the potential risk factors and predictors of persistent diarrhea following S. typhimurium infection. As a result, body temperature, C-reactive protein (CRP) levels, alanine aminotransferase (ALT) levels, white blood cellcount, and lactose intolerance were significant predictors of persistent diarrhea. Nomogram models developed based on these predictors demonstrated robust performance in predicting persistent diarrhea risk, with an accuracy of > 90%.
Conclusions: The developed nomogram models provide a practical tool for the early identification of children at high risk of persistent diarrhea, facilitating intervention, potentially preventing serious sequelae, and improving the prognosis of children with S. typhimuriumenteritis.
Molecular Characterization of Vascular Plant Species from Antarctica (Deschampsia antarctica and Colobanthus quitensis) and Some Temperate and Tropical Cereal Crops Using Inter-Primer Binding Site (iPBS) Molecular Markers
Authors: GLEKU Olivet Delasi , SERCE Sedat
Published: January 2024

Antarctica vascular species are of vital importance for plant breeding and ecosystem studies due to their extreme environmental adaptabilities. However, limited molecular studies exist especially comparing Antarctica vascular species and other cereal species from the Poaceae family. In this study, the two vascular plant species; Deschampsia antarctica and Colobanthus quitensis found in the Antarctic ecosystem were molecularly characterized using 45 inter primer binding site (iPBS) retrotransposon markers. The Antarctica species were sampled from various locations in the Antarctica region during a scientific expedition. Five temperate cereal species; Avena sativa, Secale cereale, Hordeum vulgare, Triticum durum, and Triticum aestivum, and one tropical cereal species, Sorghum bicolor were also included for comparative analysis. A total of 23 individuals in two replicates all from the Poaceae family were assessed in this study. The iPBS markers produced 1506 scorable reproducible bands of which 1226 bands were polymorphic. The dendrogram based on the UPGMA clustering and principal coordinate analysis (PCoA) classified the speices into three distinct clusters. High variabilities existed between the Arctic, temperate and tropical species indicating their geographical diversity and adaptations. The results of the present study provides basis for further research on these species to identify sources of variation for climate resilience and resistance breeding for sustainable agriculture. Further study is recommended to assess the phylogenetic relationship among these species.
Access to optimal treatment of acute myeloid leukaemia patients is affected by sociodemographic factors: a French population based-study.
Authors: ATSOU Kueshivi Midodji , RACHET Bernard , MARINGE Camille , CORNET Edouard , CHRETIEN Marie-Lorraine , ROSSI Cédric , REMONTET Laurent , GIORGI Roch , GAUTHIER Sophie , GIRARD Stéphanie , BÖCKLE Johann , WASSE Stéphane Kroudia , RACHOU Helene , BOUZID Laila , PONCET Jean-Marc , ORAZIO Sébastien , MONNEREAU Alain , TROUSSARD Xavier , MAYNADIE Marc
Published: January 2024

Background
During their care pathway, AML patients not admitted to Specialized Haematology Units (SHU) have less access to curative treatment. We aim to determine whether access to optimal curative treatment is affected by sociodemographic factors.
Methods
We included 1,033 incidents AML-cases diagnosed between 2012–2016 from three French “départements”. We considered patients managed in reference hospitals SHU within 5 days(n = 297) received “gold-standard” treatment. Treatment was "curative-treatment” if intensive chemotherapy and “non-curative” otherwise. Firstly, we trained a Gradian Boosting Machine (GBM) algorithm on 80%(n = 238) of "gold-standard" cases to learn how they were treated and validated the model on the remaining 20%(n = 59). Next, GBM predictions were contrasted with actual treatment. Using multivariable logistic regression, we examined how non-optimal treatment (discrepancy between predicted curative and observed non-curative treatment) was associated with sociodemographic factors. Patients with predicted non-curative treatment were excluded as uninformative on access to curative treatment (n = 471).
Results
The rate of “curative treatment” was 84.8% (252/297) for gold-standard patients vs. 33.5% (247/736) for others. The three most influential predictive factors in gold-standard patients were age (68.3%-influence), t-AML/MDS (15.8%), and the AML-others subtypes (5.4%). A total of n = 102(9.9%) patients were in non-optimal treatments. Living in Basse-Normandie (0.65-times;95%CI [0.5,0.8]) and over 30minutes from a reference hospital were strongly associated with a non-optimal treatment.
Conclusions
There are geographical disparities in access to optimal treatment, potentially linked to medical desert situations or medical system organization.
‘It’s a rich people’s disease...’: Community perceptions about and responses to the coronavirus pandemic in Bangladesh
Authors: Sony M M Abdullah Al Mamun , Hasan Md Kamrul , Roy Tuhin , Basu Banga Kamal
Published: January 2024

The coronavirus pandemic has emerged as a major global social and health issue. A large body of research on this problem has largely been quantitative, epidemiological, and virological. There has been little exploration of how the general public frames this problem and how they respond to it. To address this gap, the purpose of this study is to explore community peoples' perceptions of and responses to the coronavirus pandemic within the existing sociocultural context of Bangladesh. A total of 46 semi structured interviews were conducted in a city and three remote villages located in the Khulna Division of Bangladesh in 2020. The interview transcripts were analyzed by applying Strong’s ideas about psychosocial responses to pandemics and the ‘risk’ theories of Ulrich Beck and Anthony Giddens. The findings showed that psychosocial responses included fear, anxiety, protective behaviors, excessive precautionary practices and widespread community-level stigma. These risk perceptions, as well as responses, were influenced by a wide variety of social, cultural, economic, educational, religious and locational factors. The findings will inform the development of more effective intervention programs by considering local cultural perceptions, beliefs and practices in relation to COVID-19.
Creating a Inexpensive, Effective Super Saturated Polymer Out of Citrus Polysaccharides
Authors: Rappoport Gray
Published: January 2024

The loss of water when farming constructs a significant environmental issue, as droughts evaporate 3o% to 75% of agriculturally used water. Retaining the water in the soil is an essential environmental act, as minimized water loss would occur, therefore acting against water depletion. The objective of this project was to create a cheap and yet effective super absorbent polymer from cross linked citrus polysaccharides, using both oranges and avocados.
I constructed a chemical system that allowed me to crosslink 17 oranges and 14 avocados through blending and a heating process of sitting in an oven for 180 degrees celsius for 20 minutes. Once the three built super absorbent polymers, and orange juice solution, an orange juice, orange peel, and avocado mixture, and a orange peel and avocado mixture were completed they were put into the soil boxes of 12 Ocimum Sanctum plants along with prebuilt super absorbent polymers acrylic, pectin, and starch. For 22 days a soil moisture meter was used to take samples of moisture from each of the soil boxes and a ruler was used to measure the plant’s height. Once found, the moisture levels, height, and number of leaves of each plant were placed into a data table on a macbook air, completing the experimental procedure.
The combined mixture of orange peels, orange juice, and avocado peels stayed above a moisture level of 8 for 17 days and gained 2.03 cm of height proving that it was the most effective super absorbent polymer. This critical result was then achieved as only four leaves were lost for 16 days of testing.
Creating a cheap yet effective superabsorbent polymer from crosslink citrus polysaccharides proved to be an effective objective and may change the future of farming.
A Study on the Deaeration Effect of N2 Nanobubbles Using Friction Tube
Authors: Yoo Taekeun , Yoo Young-Ho , Byun Suk-Joo , You A-Ram , Park Chang-Hee , Choi Dae-Hyun , Jun Eun-Hee , Kim Gi-Han
Published: January 2024

The dissolved oxygen in water has a role in causing oxidation reactions that corrode devices and other objects. Thus, the removal of dissolved oxygen, known as deaeration, is a crucial task in the industry. This study investigated whether it is possible to generate deaerated water with more than 90% dissolved oxygen (DO) removal by injecting nitrogen(N2) into an apparatus that generates nanobubbles using the friction tube method, in order to minimize the deaeration process and improve efficiency. The deaeration reaction time and economic feasibility of nanobubble generation using a friction tube were examined. Furthermore, this study verified the possibility of a downsized deaerator that can be easily converted into a mid- and large-sized device depending on the needs of research laboratories, cosmetics, personal care, and food industries, as well as specific company situations. Finally, the applicability of this deaerator in the chemical and construction sectors and facilities requiring industrial water, such as power plants and heating system pipelines was verified.
CAPM Model and Optimal Risky Portfolio for American Stock Market
Authors: Rong Runsheng
Published: January 2024

The stock market has high risks. The purpose of this project is to calculate the beta coefficients and build the optimal risky portfolio consisting of eight different stocks each representing different significant industries (which includes information technology, electric cars etc.) to diversify risk and gain a high return. Putting more stocks into the portfolio can help analysts carry out comprehensive analysis on different situations, periods, and types of investment portfolio, so as to disperse risks and obtain high returns, also, ensure the diversity of portfolio and a lower risk. The empirical results in this paper shows that by allocating their money appropriately in different stocks, investors can gain returns multiple times higher than putting all of them in merely one single stock, which proves the validity of this paper.
Petra Elser, Jg. 1963
Authors: Krause Ines Kinga
Published: January 2024

Petra Elser gehört zu den wenigen Personen, die baskische Literatur direkt aus der Originalsprache ins Deutsche übersetzt haben. Aufgrund der Themen der von ihr übertragenen Literatur sowie ihrer Vergangenheit kann ihr übersetzerisches Œuvre als "politisch aufgeladen" bezeichnet werden. Neben dem Übersetzen hat sie sich auch für das Erlernen des Baskischen engagiert.
Remote behavior audit of hazardous activitiesand conditions in the oil and gas industry during video monitoring
Authors:   Irkutsk National Research Technical University, Timofeeva Svetlana , Khramenok Maksim ,   Irkutsk branch of RN-Burenie LLC, Zyabrov Aleksandr ,   Irkutsk branch of RN-Burenie LLC, Marchenko Ivan ,   Irkutsk branch of RN-Burenie LLC
Published: January 2024

The article discusses the problem of implementing a behavior safety audit, which is an effective tool for preventing industrial injuries and the basis for creating a behavioral model of workers. The article describes the behavior safety audit aimed to identify unsafe worker actions and hazardous work conditions at hazardous production facilities in the oil and gas industry. The possibility of conducting a behavioral safety audit is substantiated based on the analysis of video recordings of work at hazardous production facilities during drilling operations, underground and major well repairs. The study suggests conducting the remote behavior safety audit of “hazardous actions” and “hazardous conditions” in order to identify and prevent possible dangerous situations when performing standard and high-risk works. Flowcharts of the sequence of remote behavior safety audits of “hazardous actions” and “hazardous conditions” are presented.
A new approach to ensuring acceptable working conditions in mines using ventilation equipment
Authors:   Perm National Research Politechnical University, Fainburg Grigorii
Published: January 2024

The study analyses issues of rational maintenance of the breathable and explosion-proof air environment in the working areas of underground mines using mine ventilation equipment. The article justifies the need for a paradigm shift in the ventilation system and a transition from diluting harmful substances in the air throughout the working area to a multi-zone division of free air space and maintaining acceptable air quality in the breathing zones of miners through the displacement/advective transfer.
Study of the lighting characteristics of Uniel retrofit LED lamps
Authors: Ashryatov A. A. , Kuznetsov E. A. , Smolin K. A.
Published: January 2024

The paper considers the photometric characteristics of LED retrofit lamps produced by the Russian-Chinese company Uniel: Uniel LED-G45-6W/4000K, Uniel LED-A60-8W/6500K, and Uniel LED-A60-9W/4000K, designed to replace traditional incandescent bulbs. During the research, comprehensive measurements of photometric parameters (luminous flux, power consumption, color temperature, color rendering index, ripple factor, power factor) have been carried out and the luminous efficacy has been calculated. The results of the measurements have been presented in relation to the supply voltage. Based on the data obtained, an analysis is carried out of the compliance of the initial measured characteristics of the lamps with the values declared by the manufacturer. The analysis of the emission spectra leads to the conclusion that the Uniel LED-A60-8W/6500K lamps are equipped with white light-emitting diodes, the spectrum of which consists of a blue emission band from the semiconductor crystal with a maximum at ~450 nm and a phosphor band with a maximum at ~560 nm, which converts some of the blue emission from the crystal into long-wavelength spectrum. The emission spectra of the Uniel LED-G45-6W/4000K and Uniel LED-A60-9W/4000K lamps, in addition to the blue emission band from the semiconductor crystal with a maximum at ~450 nm, contain emissions from two phosphors, the bands of which have maxima at ~560 nm (green) and ~630 nm (red), which results in a lower color temperature of the LEDs. The paper also provides a detailed analysis of the light power distribution curves, thermal operating conditions, and structural features of the lamps. The research results lead to the conclusion that it is advisable to recommend Uniel LED-G45-6W/4000K and Uniel LED-A60-9W/4000K lamps for use as light sources to replace traditional incandescent lamps because their photometric characteristics comply with the declared parameters and permissible deviations specified in the regulatory standards.
Study of technical parameters of magnetic starters and switches installed in workshop networks
Authors: Petrov A. R. , Gracheva E. I. , Valtchev S.
Published: January 2024

The study of technical parameters of low-voltage switching devices of Russian production – magnetic starters PML and switches RE19 has been carried out. The problem of evaluating energy efficiency of operation of magnetic starters and switches installed in in-plant power supply systems has been presented. The main destabilizing factors significantly affecting the technical characteristics of switching devices with voltage up to 1 kV have been given. Reliability of functioning of the investigated devices, first of all, depends on the degree of wear of switching contacts. The dependences of the heating temperature of the contact areas of switching devices on the loading coefficient have been studied. It has been revealed that with the increase of loading of devices in the range from 1,0 to 2,0Inom the temperature of contacts and contact areas is within the permissible limits in accordance with the requirements of GOST 403-73. The main factors influencing the resistance of contact connections – current flowing through the contacts, their dimensions and heating temperature – have been shown. According to the results of theoretical and experimental studies approximating functions of dependences of resistance of contacts and contact connections of switching devices on rated current have been developed and errors of the calculated method of contact resistance estimation have been determined. The developed dependencies can be used to determine the equivalent resistance of networks of in-plant power supply when estimating the level of power losses, which will increase the reliability of the results obtained.
Methods for assessing the reliability of in-shop power supply
Authors: Petrova R. M. , Gracheva E. I. , Valtchev Stanimir , Miftakhova N. K.
Published: January 2024

Research activities in the field of development of electrical power and electrical equipment include the development of new approaches to assessing the reliability indicators of electrical equipment elements and in-house power supply systems in general. The study has examined methods for assessing the reliability of electrical equipment in intra-shop power supply systems using the example of a workshop network section, including its main elements: power transformer, low-voltage cable lines, distribution points, circuit breakers, magnetic starters, contactors, switches. The reliability parameters of the circuit are calculated relative to the distribution cabinet of the power (DCp) and the distribution point of the power (DPp); regarding each connection of DCp and DPp. The methods under consideration are recommended to be used to clarify the frequency and timing of maintenance and repairs of electrical equipment of the in-shop power supply system, as well as to analyze the reliability of operation and identify the least reliable sections of network diagrams. The presented calculation using the logical-probabilistic method by constructing a fault tree is advisable to use to estimate the frequency of power loss of DCp and DPp, as well as individual connections. For the studied circuits, graphical dependences of the probability of failure-free operation of electrical equipment and the occurrence of a failure over time have been constructed.
Results of a statistical study of types of single-phase faults in low-voltage ship electrical networks
Authors: Kazhekin I. E. , Kharitonov M. S.
Published: January 2024

The increase in the power supply of ships is manifested in growth of ship power plants' capacity, the total length of cable lines, and the number of electrified mechanisms. With the development of marine technology, the severity of the consequences of damage to ship electrical equipment and the costs of its maintenance and repair increase. The search for ways to improve the reliability and safety of electrical equipment should be based on design and technological solutions at the stages of its development and production, as well as an analysis of various factors that may appear during the operation of marine equipment and affect the condition of ship electrical systems. During studying these factors, it has been revealed that one of the common types of damage to electrical equipment of marine equipment is single-phase short circuits, the causes of which are varied. Preventing short circuits is labour intensive and in some cases impracticable. However, understanding the characteristics of this type of damage to low-voltage equipment is necessary to improve the reliability and safety of ship electrical systems. The conducted research is based on a survey of ship electrical mechanics. The results of the surveys have made it possible to analyze the frequency of occurrence of single-phase insulation faults, the duration of their existence, to identify the most likely places of occurrence of short circuits and equipment that is more susceptible to such damage compared to other elements of the electrical power system.
The single phase-to-ground fault location calculation method based on limited information on the distribution of zero-sequence voltages on the tree-structured feeder
Authors: Fedotov A. I. , Vagapov G. V. , Abdullazyanov R. E. , Fedotov E. A.
Published: January 2024

One of the key goals in the overhead power lines at the isolated neutral system 6–10–35 kV is topographic search area limitation for a single phase-to-ground (SPG) fault. This will ensure reliability improvement warranty and continuity of power supply. No fault founded in time can lead to failure of electrical equipment. Faults can initiate a ground fire in dry-weather period, which requires preventive shutdown of power lines with subsequent economic damage to power supply organizations. The paper proposes the use of emergency mode parameters, namely, zero-sequence voltages, in order to determine the faults locations in a calculated way. The need for additional installation of measuring voltage transformers at terminal substations is associated with some financial costs. In this regard, the possibility of their limited use is being considered. It has been shown that in this case the emergency section can be localized with accuracy down to the tap if there are no measuring voltage transformers on it. To calculate the SPG location, a mathematical model of lines with distributed parameters has been used. Signals at higher harmonics (HH) generated in the electrical network by arc faults, are considered useful. Full-scale experiments show the HH presence also during electrical contacts of wires with metal structures. The high frequency of the signal causes a significant change in voltage along the length of the line, which increases the accuracy of calculations. The use of zero sequence voltages promotes detuning from the influence of substation load. An algorithm has been developed for performing calculations to determine the location/area with a ground protection zone on a tree-structure feeder.
Application of the "electronic nose" for evaluating volatile compounds of semi-finished small fish
Authors: Alloyarova Yu. V.
Published: January 2024

The production of canned food is one of the dynamically developing segments of the fishing industry. An instrumental assessment of the composition of highly volatile fractions (aromas) of smoked semi-finished capelin products sent for the production of canned food has been carried out using a MAG 8 odor analyzer in the equilibrium gas phase above the samples. To reliably establish differences in the composition of highly volatile compounds, the method of preliminary concentration of components in a sampler has been used. After saturation of the free space above the sample, the signals increased from 2.5 to 3 times when the sensors were loaded with the equilibrium gas phase. However, no fundamental differences in the nature of the influence of different methods of processing semi-finished capelin products have been established. Under native (natural) conditions for the formation of the odor of capelin samples and their preliminary concentration in the equilibrium gas phase, the qualitative and quantitative compositions of the odor differ, but the tendency remains for a higher content of compounds in the sample treated with smoke gel compared to frozen capelin and the sample treated with a smoke-air mixture. For saturated vapors, it has been established that according to 3 parameters (contributions to the sorption of sensors 1, 3, 8), samples treated with a smoke-air mixture and smoke gel have a similar composition (unlike frozen capelin). Sensors 5, 6 and 7 do not distinguish the smell of all samples, i.e. they react to volatile compounds of capelin. Sensor 4 reflects the proximity of the moisture indicators of frozen capelin and capelin treated with smoking gel. As a result of the correlation analysis, the correspondence of the obtained chemical samples has been established, including a greater influence on the composition of highly volatile fractions (aroma) when using a smoke-air mixture compared to using a smoking gel.
Features of the selection of starter cultures in the production of functional fermented milk products
Authors: Kanochkina M. S. , Ivanova L. A. , Konovalova A. D. , Levin O. N.
Published: January 2024

Modern trends in the formation of a healthy lifestyle have led to the active development of technologies for the production of functional fermented milk products. The selection of a rational combination of lactic acid bacteria and bifidobacteria for creating starter cultures should provide products with functional properties and take into account the following criteria: the product must be safe (each microorganism included in its composition must be tested and assessed from a safety point of view, including confirmation of the absence of genes antibiotic resistance); the product must have nutritional value; the product must meet certain quantitative characteristics (amount of probiotics, acidity level, energy value). In the course of studying the features of the selection of starter cultures (lactic acid bacteria and bifidobacteria) in the production of functional fermented milk products, a search (using key words) for literature sources published between 2012 and April 2023 was carried out and related to the development of starter cultures and functional products. Using three search engines, 105 sources were selected and checked for compliance with the designated inclusion criteria. Among the selected sources, only 69 could be applicable for writing a review that has examined the effect of functional fermented milk products on the human body and has analyzed the potential of using lactic acid bacteria and bifidobacteria as a component of the starter composition.
Faktor-Faktor yang Mempengaruhi Kepuasan dan Minat Beli Ulang serta Loyalitas Pengguna Tokopedia
Authors: Kurniawan Laura , Tjahjadi Djajasukma
Published: January 2024

Advances in technology have provided many conveniences in carrying out daily activities. One technology that is widely used today is online shopping as an application of the e-commerce system. One of the leaders of online shopping platform in Indonesia is Tokopedia. Tokopedia has received many awards, including Best Company in Consumer Industry in Indonesia Digital Economy Award in 2016 , and the Top 50 Most Valuable Indonesian Brands 2016 award. Along with the rapid development of the online shopping world, Tokopedia has to face its competitors. This paper is to study the factors influencing satisfaction which are trust, ease of use and service qualtity, and the factors influencing repurchase intention which are brand image, price perception, and promotion. The effect of satisfaction and repurchase intention on Tokopedia’s consumer loyalty was also studied. Using path-analysis method, 300 respondents were surveyed to test the research model. The result shows that trust, ease of use, service quality, were significantly has effect on customer satisfaction. Price has effect on repurchase intention, but brand image and promotion showed no effect. This study is also shows that customer satisfaction has no effect on customer loyalty, but repurchase intention has significant effect on customer loyalty.
Digital Marketing as a Tourism Village Marketing Strategy in East Java’s Horseshoe Region
Authors: Nurmadewi Dita
Published: January 2024

If supported by digital marketing, tourism villages can be a major economic driver in rural communities. Because through digital marketing, the tourism industry is able to expand its market and attract more tourists. This study intends to map the need for information technology for digital marketing as a strategy to enhance the marketing of tourism villages. This study employs a qualitative case study methodology. Tourism villages of Kemiren in Banyuwangi Regency, Lombok Kulon in Bondowoso Regency, and Kampung Blekok in Situbondo Regency served as research sites. Observation, interviews, and documentation techniques were utilized to collect research data. The data analysis employed qualitative descriptive analysis. According to the findings of the survey, the marketing of tourist villages in the Horseshoe region has been conducted using information technology. However, the use of digital marketing through websites and social media is still limited. Therefore, digital marketing must be supported in accordance with the requirements of the tourist village and the segmentation of the target market. This research's information technology requirements mapping methodology for digital marketing can be utilized to support the marketing of tourist villages in East Java’s Horseshoe region.
Evaluasi Kualitas Shopeepay Menggunakan ISO/IEC 25010
Authors: Rumabar Bithia Insoraki , Maria Evi
Published: January 2024

This research aims to evaluate the quality of Shopeepay using ISO/IEC 25010 from the user side, namely Satya Wacana Christian University students. Evaluation of the quality of Shopeepay needs to be done because the high level of use of Shopeepay is also followed by increasing user complaints. This research assesses eight characteristics: functional suitability, reliability, performance efficiency, usability, security, compatibility, maintainability, and portability. There were 140 respondents in this research. This research uses a quantitative descriptive approach, and data is analyzed by calculating the total score for each characteristic regulated in ISO/IEC 25010. The results of the Shopeepay quality evaluation found that functional suitability is 79%, performance efficiency is 75 percent, compatibility is 74 percent, usability is 78 percent, and reliability is 77 percent, security 83 percent, maintainability 76 percent, and portability 78 percent. The quality of Shopeepay is considered very good from a security perspective, and the rest is good. The lowest score is on the compatibility aspect, so system developers and Shopee management need to improve the compatibility of this application because payment transactions and top-up balances fail due to this aspect.
A Study on the Relationship between Tea Life and Wellness of Generation MZ Women
Authors:   Association for International Tea Culture, Son Jin-sun , Choi Bae-young
Published: January 2024

The purpose of this study is to figure out the tea life behavior patterns of MZ generation women and to identify the relationship between tea life and wellness. For this purpose, an in-depth interview was conducted with 10 women in their 20s and 30s who have experienced tea life for more than 6 months, and the data were analyzed according to the MEASC model. The results of this study can be summarized as follows: First, the motivation of MZ generation women's tea life was induced for the health of mind and body, through the recommendation of family, or through education at university. Second, the exploration of tea life information consisted of various channels such as online (e.g., YouTube/Instagram/blog), offline (e.g., acquaintance recommendation/club activity/reading/pop-up store/expo visit), and online/offline (e.g., SNS and pop-up store). Third, tea drinking action was not only practiced by individuals at home or at work, but also with family members and school club members. In addition, communal drinking among MZ generation women naturally led to the sharing of tea drinking experiences. Fourth, MZ generation women confirmed the wellness that tea life brings to them and provided self-feedback.
Revealing Religious Discrimination Experience against Indonesian Muslim Women in the United States of America
Authors: Salama Nadiatus
Published: January 2024

Muslims in the United States (US) face religious discrimination due to an increasingly hostile environment. Further research is needed to explore the dynamics of gender differences in terms of religious discrimination as Muslim women are usually more pessimistic about their position in society compared to men. This study explores the experiences of Indonesian Muslim women in the US facing religious discrimination using qualitative methods that focus on socio-religious and psychological perspectives. In-depth interviews are conducted in Bahasa Indonesia with purposively selected respondents who are women aged 26 and above. The results demonstrate that respondents are: 1) feeling humiliated by others, 2) feeling intimidated, 3) experiencing hateful speech, and 4) experiencing religious microaggressions. This study emphasizes the need to raise awareness and promote education to combat negative stereotypes and prejudices against Muslims, particularly Muslim women, for a more inclusive and tolerant society.
Exploring a Gender Equality-based Sex Education Model: Case of SMA Harapan Mandiri in Medan, North Sumatra
Authors: Damanik Fritz Hotman Syahmahita , Saliman Saliman
Published: January 2024

Gender-based sex education is increasingly crucial in schools, especially high school. Despite various studied models, gender-sensitive sex education remains unexplored. This research aims to identify a gender-sensitive sex education model at SMA Harapan Mandiri Medan, North Sumatra, using a qualitative approach. Data collection involves observation, interviews, and documentation, which is analyzed through reduction, presentation, and NVivo 12 Pro mapping. Results show the successful initiation of a comprehensive sex education model at SMA Harapan Mandiri. The model integrates into the curriculum, includes teacher training, fosters inclusivity, adopts anti-discrimination policies, promotes respect for diversity, educates on the negative impacts of teenage dating, involves parents, and offers information resources. The anticipated positive impact is that SMA Harapan Mandiri will become a hub for improved student mindsets through responsive sex education, fostering literacy in sexual differences, and promoting respect toward the opposite sex.
Educação e território
Authors: Kemil Fahid da Costa , Nascimento Afonso Welliton de Sousa , Pereira Maria do Socorro Vasconcelos
Published: January 2024

Este artigo objetiva analisar os marcos teóricos e legislações educacionais relativos ao Ensino Médio, refletindo sobre a relação entre educação e território e sua materialização nas políticas públicas educacionais. Os principais marcos em vigor para o Ensino Médio são a Lei de Diretrizes e Bases da Educação, o Plano Nacional de Educação e a Lei nº 13.415/2017, que estabelece o novo Ensino Médio. Por meio de pesquisa bibliográfica e documental, identificou-se que, além de focarem em aspectos mercadológicos e não na formação humana, esses marcos legais não projetam ações para a escola pública brasileira de modo condizente com a realidade desse espaço plural. A proposta de um Ensino Médio como preparação para o mercado de trabalho não só intensifica diferenças entre as redes pública e privada, como também afeta os sujeitos em seus territórios, alterados pela tentativa de uniformização da política.
Da Preparação do Texto à Delineação de Estratégias Pedagógicas um Possível Percurso de Compreensão da Leitura da Obra O Dragão, de Luísa Ducla Soares
Authors: Oliveira Inês
Published: January 2024

The present article intends to reflect on the work of preparing the text before delineating pedagogical strategies, valuing the linguistic knowledge of the Portuguese L1 teacher for the delineation of a sustained and coherent didactic path. The text assumes the central role of the class countless times, trying to make the student reflect on their linguistic structures. In this context, the book O Dragão, by Luísa Ducla Soares, constitutes the starting point for exemplifying a possible text preparation work. It is intended to emphasize that this previous moment of textual analysis allows highlighting the pedagogical potential of the text, so that, in a second moment, depending on the objectives and the class, a didactic route can be defined. Finally, it is in this line, in which text and reading are assumed as fundamental aspects in Portuguese classes, that a possible reading route is presented, taking into account the specific methodology of this domain.
A curta-metragem como recurso didático na aula de PLE Duas propostas didáticas
Authors: Matos Catarina Raposo Santos de , Carvalho Ângela Cristina Ferreira Renna de
Published: January 2024

This article presents a case study developed with the purpose of investigating the relevance of using short films as educational material for teaching Portuguese as a Foreign Language. The study was conducted with an A2 level class, of the Annual Course of Portuguese for Foreigners for the academic year 2016-2017, during the Pedagogical Internship undertaken within the scope of the Master in Portuguese as Second Language/Foreign Language, Faculty of Arts and Humanities, University of Porto. Considering the State of the Art together with the analysis of the intervention context, two educational proposals using short films were planned and implemented, following the methodological principles of Task-based Language Teaching. Data was then collected and analyzed. The results obtained confirmed the wide possibilities of using short films for the design of motivational activities aimed at different syllabus content thus providing a relevant tool for the integrated practice of primary language activities and for the development of the different communication skills.
Pelestarian Kesenian Debus Banten di Padepokan Maung Pande
Authors: Yosef Calasanza  , Gunawan
Published: January 2024

Debus is one of the popular arts in Banten society. During the Banten kingdom, in the past Debus art became well-known. Initially, Debus became a medium for spreading Islam in Banten. During the colonial period, debus used against colonial troop. Debus perpetrators who are aware of their immunity to sharp weapons and bullets form a force to confront the colonial army. After independence, Debus developed into an art that is often staged in various events at the regional and national levels. However, recently its popularity has waned. Debus art is not much staged and known in the community. This circumstance has prompted Banten hermitages to promote and preserve Debus arts. This article aims to describe the activities of the hermitage in maintaining the existence of debus as well as activities to preserve the Banten debus art by Padepokan Maung Pande. The data collection method was carried out using qualitative research methods by focusing on data collection on member of the Maung Pande hermitage. The results of the study show that the conservation efforts carried out by the Maung Pande hermitage are carried out by collaborating with schools in Banten province.
Hermeneutika Dialogis sebagai Basis Filosofis dalam Fiksyen dan Sejarah, Suatu Dialog Karya Umar Junus
Authors: Suharmono
Published: January 2024

This study aims to explain dialogical hermeneutics, one of the scientific paradigms that can bridge the confusion of thinking in explaining the relationship between literature and reality/history. The material object used is Fiction and History of Dialogue, while the formal object is the dialogical hermeneutic paradigm in the book. The purpose of this study is to describe the basic assumptions; model; and the concepts that make up dialogic hermeneutics. The theoretical framework and method used as the basis for the analysis are Thomas Khun's thoughts related to paradigms. The results of the research show that Fiction and Dialogue History books criticize in discussing fiction which is dominated by mimetic and semiotic concepts as well as history which is seen as something that is often contrasted with fiction. Junus offers an alternative idea in the form of dialogue (hermeneutics) as a new way of looking at the relationship between fiction and history/reality. Junus uses an analogy model to see the relationship between fiction and history/reality. The concepts put forward include the Concept of Definition of Fiction; The Nature of Reality in Stories; Fiction and Heurmenetics; Fiction Shapes Reality; Perspective of Fiction and Reality of Writers and Readers; and Fiction and History.
Research on Constraints and Countermeasures of Forest Carbon Sink Economic Development in Sichuan Province
Authors: Huang Ling
Published: January 2024

In response to global climate change, China has made a solemn commitment to achieve carbon peak by 2030 and carbon neutrality by 2060, with the development of carbon sink economy being an important approach to fulfill the dual carbon goals. Sichuan Province, with its abundant forest resources and vast territory, possesses a strong carbon sink capacity, which naturally lends itself to the development of a carbon sink economy. Based on Sichuan Province, this paper analyzes the current situation and challenges of carbon sink economic development, explores the ecological compensation mechanism for carbon sink economy under the dual drivers of ecological protection and economic development, harnesses the ecological functions of carbon sink economy, and contributes to the realization of the dual carbon goals, in line with the concept of “Clear waters and green mountains are invaluable assets”.
APTAMERS: NANOMATERIALS AS A POTENTIAL AGENT FOR ANTIVIRAL THERAPEUTIC DRUG DELIVERY DEVELOPMENT: A SYSTEMATIC LITERATURE REVIEW
Authors: REDDY MUTHADI RADHIKA , GUBBIYAPPA SHIVA KUMAR , RASHEED SHAIK HARUN , PARAMESHWAR KONDAPURAM
Published: January 2024

Chemotherapeutic experts have been utilised to cure a variety of disorders, but their practical application is restricted due to their regrettable selectivity and outrageous fundamental optional effects. Short single-stranded DNA or RNA oligonucleotides known as aptamers are released from randomised libraries and have strong propensity and differentiation towards targets like antibodies as well as characterised structures and ties to targets like proteins. They commonly suppress protein interactions while restricting proteins, which may elicit positive effects like threat. Aptamers have recently demonstrated their amazing promise for use in medicines, biosensors, and bioimaging thanks to a number of advantages, such as minimal immunogenicity, simplicity of giant degree blend, low pack to-bunch collection, genuinely substance modification, and programmability. At any rate, the steady for the most part accomplishment speed of aptamer is far from being brilliant, despite everything needs to overwhelm the gigantic obstruction in propensity, constancy for utilitarian application, explicit illness cell affirmation. The sensible method of controlling the binding execution of aptamers and dealing with their show in the practical application is of great significance and these single-abandoned DNA or RNA aptamers could outline with astoundingly poisonous chemotherapy drugs, hurts, strong RNAs or different particles as novel aptamer-drug structures, which are prepared to do endlessly out working on the obliging plentifulness and decreasing the critical danger of solutions and have unprecedented possible in living spaces for appointed ailment treatment. In this survey, we have extensively covered and summarised the ongoing improvements in the aptamer-drug structure philosophy for designated drug transport in the assessment methodologies of aptamers for unambiguous disease biomarkers. A modified strategy utilising aptamers could be a reliable system for quick and precise advancement of biopharmaceutics for use in infection-related treatment, especially in light of the enormous advances in modernised thinking for protein and RNA structure conjectures. Additionally, the likelihood of future conception is also summarised.
PREPARATION AND SOLID-STATE CHARACTERIZATION OF KETOPROFEN-SUCCINIC ACID-SACCHARIN CO-CRYSTAL WITH IMPROVED SOLUBILITY
Authors: IMANTO TEGUH , WIKANTYASNING ERINDYAH R. , NURWAINI SETYO , AMALIA MONICA , SAMBUDI NONNI S. , HARUN NOORFIDZA Y.
Published: January 2024

Objective: This study aimed to improve the solubility of Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID) that belongs to the Biopharmaceutical Classification System (BCS) Class II, through co-crystallization using succinic acid and saccharin coformers in a 1:1:1 and 2:1:1 molar ratio.
Methods: The slurry method was utilized to prepare the ketoprofen co-crystals, which were then subjected to various physical-chemical characterization techniques such as melting point determination, dissolution studies, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectroscopy.
Results: The results showed that the 1:1:1 molar ratio of ketoprofen-succinic acid-saccharin co-crystal (Formula 1) exhibited higher solubility than the solubility standard of Ketoprofen and the 2:1:1 molar ratio of the co-crystal (Formula 2). The dissolution profile (Q30) of Formula 1, Formula 2, and standard Ketoprofen were 96.73±1.77, 93.09±1.16, and 70.22±4.72, respectively. These findings suggest that co-crystallization with succinic acid and saccharin conformers using the slurry method can significantly enhance the solubility of Ketoprofen.
Conclusion: The 1:1:1 molar ratio of ketoprofen-succinic acid-saccharin co-crystal (Formula 1) was the most effective formulation among the tested samples, demonstrating the highest solubility. This research may provide valuable insights for developing novel drug formulations with improved bioavailability and therapeutic efficacy.