bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of early diagnosis markers of pancreatic ductal adenocarcinoma (PDAC) using publicly available transcriptomic tumour and blood sample data
Authors: Sionakidis Aristeidis , Lalagkas Panagiotis Nikolaos , Malousi Andigoni , Vizirianakis Ioannis S.
Published: October 2022

Background
Pancreatic ductal adenocarcinoma (PDAC) is the most frequently diagnosed form of pancreatic cancer worldwide. It is associated with poor survival rates (~ 5%) mainly due to the disease being usually diagnosed at late stages. Few gene expression studies have been conducted on samples from PDAC patients, however their sample size was limited and their final outcome inconclusive. We aimed to identify general PDAC disease biomarkers that may improve earlier diagnosis and patient stratification for improved mortality outcomes.
Methods
Publicly available gene expression data from 10 studies with tumour tissue (448 samples) blood samples (128 samples) from PDAC patients prior to treatment were analysed. Validation of markers was performed using Cancer Genome Atlas (TCGA) PDAC expression data. Tissue samples had AJCC (American Joint Committee for Cancer) staging information available. Differential gene expression analysis was carried out to compare tumour and normal samples (stage-specific tissue samples vs. normal tissue samples and PDAC blood samples vs. normal blood samples). Active subnetwork search and miRNA enrichment analysis were used to identify enriched gene networks and miRNA interactions.
Results
We identified 820 consistently deregulated (either up- or down-regulated) genes between tissue samples of all stages and blood samples. The prognostic potential of these markers was validated in TCGA data in predicting PDAC outcome (dead/alive status), in the form of custom risk scores (up-regulated genes score: p = 0.004 and down-regulated genes score: p = 0.03). Active subnetwork analysis revealed enriched ribosome, proteasome, adherens junction and cell cycle pathways in tumors across all stages and blood samples. Stage-specific enriched miRNAs were also identified (miR-21, miR-29, miR-124, miR-30, for stages 1–4 respectively).
Conclusions
We identified PDAC markers deregulated across all stages and different sample sets. Extensive gene expression deregulation was found in all clinical stages with significant overlap. Additionally, miRNA contribution to PDAC pathology may be important and probably mediated by distinct miRNAs in each stage of PDAC. We therefore present a list of markers and miRNAs that could potentially act as a diagnostic tool for early detection of PDAC onset to be evaluated in other clinical and epidemiologic studies.
Joint Energy Management and Task Assignment for Mobile Servers Assisted Mobile Edge Computing
Authors: Huang Xiaoyao , Ji Guoliang , Lei Bo , Tang Jing , Lv Hang
Published: October 2022

Mobile edge computing is an important computing paradigm for delay-sensitive and computation-intensive tasks, which are growing explosively. In this paper, we study the joint optimization of task assignment and energy management in the mobile servers assisted edge computing network in order to minimize the system task delay. Considering the constraints of computing capacity of heterogeneous servers and energy capacity of mobile servers, this paper introduces the energy protection threshold to dynamically determine the energy-critical mobile servers and prevents them from participating in task processing, so as to effectively extend the overall service time of mobile computing resources, and thus finally minimize the average overall system delay. The system delay minimization problem is first formulated as a Mixed Integer Programming (MIP) problem, and we design a heuristic algorithm--dynamic Energy protection based delayed minimization Ant Colony algorithm (EACO) to solve the problem. In addition, the transition probability function is constructed according to the optimization objective and the characteristics of the ant colony algorithm. We conduct extensive simulations and the results demonstrate the high performance of the proposed algorithms compared to the benchmark algorithms.
A comprehensive audit of record keeping practice in surgical inpatients records.
Authors: Gasoma Elmuhtadi
Published: October 2022

Background
Good quality record keeping is essential to safe and effective patient care. To ensure that high standards of record keeping are maintained, regular clinical audit should be undertaken. A retrospective, descriptive study was carried out to audit and re-audit the documentation of surgical inpatient records in order to determine if the current documentation technique complies with the hospital's stated policy .
AIMS / OBJECTIVES
The main aim of the audit project was to examine current documentation process at the hospital & look at ways in which existing practice could be improved.
METHOD
By using standard hospital criteria as a basis , an electronic forma was developed to audit the standards. 120 case files retrospectively served as the primary source for the data collected. The records were assessed for completeness of documentation and presence of documentation in the correct section. The data was collected, analyzed, and presented at clinical governance. We then implemented in our documentation protocol for all surgical personnel to be given instructions on the appropriate documentation and how to complete it. This data was again, prospectively collected to complete the audit cycle.
RESULTS
Of the 37 audit standards that are comparable, 35 increased in compliance. No compliance in any of the standards of the criteria decreased in the re-audit cycle . Overall, there is an average increase in compliance across all the audit criteria of 32% since the first audit cycle , indicating that some of the work done after the first cycle has had a positive impact.
DISCUSSION / CONCLUSIONS
The keeping of records must be viewed as an essential component of medical practice; The ongoing documentation keeping work shows that when done well, audit can have a real impact on the quality of clinical records . Simply undertaking the audit can raise awareness of the need to improve practice. Dissemination of results, education and training and local action planning are all crucial to improving practice .
A Comprehensive audit of record keeping practice in surgical inpatients records.
Authors: Gasoma Elmuhtadi
Published: October 2022

Background
Good quality record keeping is essential to safe and effective patient care. To ensure that high standards of record keeping are maintained, regular clinical audit should be undertaken. A retrospective, descriptive study was carried out to audit and re-audit the documentation of surgical inpatient records in order to determine if the current documentation technique complies with the hospital's stated policy .
AIMS / OBJECTIVES
The main aim of the audit project was to examine current documentation process at the hospital & look at ways in which existing practice could be improved.
METHOD
By using standard hospital criteria as a basis , an electronic forma was developed to audit the standards. 120 case files retrospectively served as the primary source for the data collected. The records were assessed for completeness of documentation and presence of documentation in the correct section. The data was collected, analyzed, and presented at clinical governance. We then implemented in our documentation protocol for all surgical personnel to be given instructions on the appropriate documentation and how to complete it. This data was again, prospectively collected to complete the audit cycle.
RESULTS
Of the 37 audit standards that are comparable, 35 increased in compliance. No compliance in any of the standards of the criteria decreased in the re-audit cycle . Overall, there is an average increase in compliance across all the audit criteria of 32% since the first audit cycle , indicating that some of the work done after the first cycle has had a positive impact.
DISCUSSION / CONCLUSIONS
The keeping of records must be viewed as an essential component of medical practice; The ongoing documentation keeping work shows that when done well, audit can have a real impact on the quality of clinical records . Simply undertaking the audit can raise awareness of the need to improve practice. Dissemination of results, education and training and local action planning are all crucial to improving practice .
Psychological impact of the COVID-19 pandemic among health care workers in Tunisia
Authors: Jaballah Fares , Boudrigua Mohamed Moussa , Romdhane Islèm , Ferhi Mohamed , Mannaii Jihène
Published: October 2022

Background
The coronavirus 2019 (COVID-19) pandemic has caused a worldwide health crisis. In Tunisia, this large-scale health crisis urgently triggered the restructuring and reorganization of health services to support Emergency Departments, intensive care units, and continuing medical care units. Concerns about the mental health, psychological adjustment, and recovery of health care workers treating and caring for are now emerging. The objective was to assess the psychological impact of the Covid-19 pandemic on health care workers' work, psychological outcomes, and return to work.
Methods
Our study is a retrospective monocentric clinical trial. It is performed between June and July 2022 using a self-administered questionnaire to assess: (i) the impact on their work; (ii) the psychological consequences of the Covid-19 epidemic for health care workers.
Results
We collected 140 responses from 73 nurses (34.76%), 23 public health physicians (10.95%), 15 health technicians (7.14%), 13 residents (6.19%), 7 interns (3.33%), 5 workers (2.38%), and 4 medical specialists (1.90%). The HAD score for depression favoured certain symptomatology in most cases (n = 72, 51.43%) and certain symptomatology in most cases (n = 73, 52.14%) for anxiety.
Conclusions
The Covid-19 pandemic has brought about changes in the work organization and an overall increase in the workload for health care personnel.
Computational Modeling of Virally-encoded Ion Channel Structure
Authors: Weissman Alexander , Bennett Jeremy , Smith Nicole , Burdorf Carly , Johnston Emma , Malachowsky Beth , Banks Lori
Published: October 2022

Viroporins are ion channels encoded within a virus’s genome, that facilitate a range of devastating infectious diseases such as COVID-19, HIV, and rotavirus. The non-structural protein 4 (NSP4) from rotavirus includes a viroporin domain that disrupts cellular Ca2+ homeostasis, initiating viral replication, and leading to life-threatening vomiting and diarrhea. Though the structure of soluble segments of NSP4 has been determined, membrane-associated regions, including the viroporin domain, remain elusive when utilizing well-established available experimental methods such as x-ray crystallography. However, two recently published protein folding algorithms, AlphaFold2 and trRosetta, demonstrated a high degree of accuracy, when determining the structure of membrane proteins from their primary amino acid sequences, though their training datasets are known to exclude proteins from viral systems. We tested the ability of these non-viral algorithms to predict functional molecular structures of the full-length NSP4 from SA11 rotavirus. We also compared the accuracy of these structures to predictions of other experimental structures of eukaryotic proteins from the Protein Data Banks (PDB), and show that the algorithms predict models more similar to corresponding experimental data than what we saw for the viroporin structure. Our data suggest that while AlphaFold2 and trRosetta each produced distinct NSP4 models, constructs based on either model showed viroporin activity when expressed in E. coli, consistent with that seen from other historical NSP4 sequences.
A new family of Polyak and Ribiere conjugate gradient method for impulse noise removal
Authors: Mousavi Ali , Esmaeilpour Mansour , Sheikhahmadi Amir
Published: October 2022

In this paper, impulse noise removal problem is formulated as an unconstrained optimization problem with smooth objective function. It can be solved by conjugate gradient methods with desired properties (low memory and strong global convergence) in high dimensions. Accordingly, a family of the Polyak-Ribi`ere conjugate gradient directions is constructed for which the descent condition holds. Using several images, it is shown that the new methods are very robust and efficient in comparison with other competitive methods for impulse noise removal, especially in terms of the peak signal to noise ratio (PSNR).
Mathematics Subject Classification (2000) 90C30a · 90C25 · 90C90 · 68U10 · 03D15
Ethics of the Others in New Materialism
Authors:   British And American Language And Literature Association Of Korea, Woo Hyunsun
Published: October 2022

New materialism emphasizes on the nature of matter and the modes of self-transformation in our material environment. Until now, the body has remained mired through the discursive practices of biology and natural sciences. However, the body is also a material. The bodies have capacities that emerge within a multitude of organic and social processes functioning interactively and productively. Additionally, the materialization of the body entails an interlocking relationship between the organic transformations of the body and the material details of everyday life. Susan Miller’s solo performance dramatizes the materialization of the damaged body through vibrant entanglement between chemotherapy of breast cancer and her daily life. The scar on her lost breast amounts to the loss of love, material vitality and generative forces. And the unforeseen mutations and trajectories of illness are the results of trans-corporeality between biological processes and environmental conditions. This paper thus examines a new material perspective on the damaged female body through Miller’s illness narrative.
Women Paradise Across Time and Regions: Paradise and Park-ssi-jeon.
Authors:   British And American Language And Literature Association Of Korea, Jung Juyoung
Published: October 2022

This article studies two women communities in Paradise written by Toni Morrison and Park-ssi-jeon, a Korean ancient novel in perspective of comparative literature. They have common things. First, the women established their own communities, “convent” in Paradise and PiWhaDang in Park-ssi-jeon due to the pressure on their bodies by patriarchy. Second, the two communities not only heal the members but also offer energy for new lives. In the process, the communities function fantastic places. Additionally, although the two places choose voluntary isolation at first, they spread the aspects of paradise to their neighbor women, even to those who are in the enemy groups as time goes by. They have limits, however, which means that the members of “convent” are so obsessed with the role of a mother who cares for others that the convent can be said to be an ‘imperfect women paradise’. Park-ssi, the protagonist in Park-ssi-jeon, takes too much compromising attitude for patriarchy, and as a result, the Pihwadang stays in a ‘temporary paradise for women’. In conclusion, in spite of the limitations of the communities, the two spaces are not just women's communities, but women's paradise across times and regions.
Unveiling Mariana’s Inner Mind: Alfred Lord Tennyson and Julia Margaret Cameron
Authors:   British And American Language And Literature Association Of Korea, Kim Jeongsuk
Published: October 2022

This essay examines the psychological state of Mariana that was displayed in Tennyson’s pictorial poetry ”Mariana” and Cameron’s photographic illustration Mariana in order to reconsider the Victorian women’s position in the conventions of femininity. Owing to the vivid pictorial descriptions, Tennyson’s “Mariana” has been examined in terms of its aesthetic value. However, this essay argues that Tennyson’s interested in mental science boomed in the mid-nineteenth century is reflected in “Mariana.” By analyzing “Mariana,” this essay first examines how Tennyson conveyed the abandoned Mariana’s mental breakdown through the medium of landscape. Playing a role as the true interpreter of his age, a poet laureate Tennyson reflected the Victorian women’s position in the patriarchal society. This essay subsequently explores how Cameron reproduced Tennyson’s psychological portrait of Mariana’s mental disintegration in her unfocused photographic space. Unlike Tennyson’s Mariana, Cameron rather radically visualized her version of Mariana by utilizing her unique out-of-focus technique. Although Tennyson and Cameron used their own artistic methods to unveil the Victorian Mariana’s inner mind, both provide a chance to reconsider the conventions of femininity in arts and literature.
Teaching Intercultural Communicative Competence in the Asian EFL Context: A Systematic Research Synthesis
Authors:   British And American Language And Literature Association Of Korea, Park Eunjeong
Published: October 2022

In the 21st century, intercultural communication is inevitable owing to cutting-edge technologies and transportation. Thus, over the past decades, there has been an ever-increasing interest in and attention to intercultural communicative competence (ICC) in English language teaching and learning. This study reports findings from a systematic research synthesis of 20 empirical studies regarding learning and teaching ICC in the Asian English as a foreign language (EFL) context. The research questions incl ude: 1) In what contexts was ICC investigated?; 2) Who were the participants in the reviewed studies?; 3) What kinds of ICC topics were explored?; 4) What activities and tasks were involved in ICC teaching and learning?; 5) What suggestions are recommended for future research on ICC? The findings expand upon learning contexts, participants, ICC-related topics, activities involved in ICC teaching and learning. Furthermore, this paper provides preservice and inservice teachers with valuable insights as well as suggestions and recommendations for teaching ICC in teacher education. This systematic research synthesis would be of value in developing and improving ICC-focused teaching and learning in English education.
The Religious and Political Defiance and the Reinterpretation of the Morality Play Implied in Doctor Faustus
Authors:   British And American Language And Literature Association Of Korea, Kim Taeyoung
Published: October 2022

From a religious perspective, Christopher Marlowe’s Doctor Faustus has primarily been analyzed in two contrasting ways. Some critics have claimed that this play advocates orthodox Christianity and others have argued that Marlowe defies Christianity and the Elizabethan England in the 16th century. There are several reasons why the interpretation of this play has been divided into conflicting views: the confusion in the aftermath of the Reformation, the unexplained notoriety for Marlowe being an atheist, and much of his life and death that has remained a mystery. Both sides have taken a confrontational stance. Accordingly, these conflicting aspects have imposed limitations on analyzing his life and works from an objective perspective. In this paper, the author reinterprets the meaning of the morality play in Marlowe’s own position and conclude that Marlowe capitalized on the morality play as an effective way to ardently criticize the harsh and strict Christianity of England while avoiding the accusation that he is an atheist.
Analysis of frequency dependence of complex impedance and electrical characterization of Fe2O3/kaolin ceramics for civil engineering applications
Authors: Bouchehma Abdeltif , Essaleh Mohamed , Bouferra Rachid , Belhouideg Soufiane , Benjelloun Mohamed , Sfa Imad
Published: October 2022

The complex impedance spectroscopy (CIS) method is usually used in order to analyze the electrical response of different semiconducting disordered materials as a function of frequency at different temperatures. The real and imaginary parts of the complex impedance can show different semicircles in the complex plane that give evidence for the presence of both bulk and grain boundary contributions. Many parameters can be deduced from the analysis of CIS data, such as relaxation times and activation energies. There are some literature data concerning electrical properties of clays and (semiconductor, sand, cement,…)/clay mixtures. Most of the published works are related to the AC conductivity of rocks with the effect of water or oil content but there are no similar studies on the characterization of the microstructure of individual clays as ceramic materials by analyzing their temperature and frequency dependence of their electrical conductivities. Hence, this paper presents an analysis of electric complex impedance of the Fe2O3/Kaolin composite in the high temperature range up to 740 °C. Sinusoidal voltage with frequency in the range [100 Hz, 1 MHz] is applied to the material in order to measure the electrical conductivity for various concentrations of Fe2O3 from zero to 100 %. The activation energies for the conduction and for the relaxation processes are determined and their dependence on the density of Fe2O3 analyzed. Furthermore, let’s found that Fe2O3 have the effect to increase the electrical conductivity in our samples. From the Nyquist diagrams, only one semi-circle related to the contribution of the grains to the total electrical conduction is identified for all investigated samples.
Research and analysis of characteristics of fuel from organic and industrial waste
Authors: Nurkina Sholpan , Kinzhibekova Akmaral , Prikhodko Evgeniy
Published: October 2022

The article is devoted to the actual problem of utilisation of agricultural and industrial waste as a solution to the problem of replacing traditional energy sources.

As an alternative fuel, researchers suggest using briquettes from biomass (leafy debris, waste paper, sunflower and buckwheat husks), as well as their combination with industrial waste (coal dust). The choice of these sources of raw materials is determined by their presence in the north-eastern part of Kazakhstan.

Studies of the physical and mechanical and thermophysical characteristics of fuel briquettes from organic mass and bio-charcoal briquettes were carried out. The studies showed the following results: the moisture content of the samples we studied lies in the range from 3.86 to 8 %; ash content of briquettes from vegetable raw materials varies from 2.05 % to 3.6 %, combined briquettes from foliage and coal dust varies from 10 % to 14 %; average density values varies from 979.91 to 1172.63 kg/m3; mechanical strength is in the range from 90 to 100 %; the yield of volatile studied samples ranges from 9 to 21.4 %. Analysis of the obtained characteristics of fuel briquettes demonstrated that they meet the requirements of existing standards. Herewith, the lower calorific value of briquettes (15290‑19048 kJ/kg) is comparable to the calorific value of coal from the Ekibastuz deposit.

The authors studied the influence of the parameters of the briquetting process on the briquette’s strength characteristics from leaves and waste paper, and obtained a regression dependence of these briquette’s calorific value on their characteristics. The analysis of regression dependencies showed that the pressure and pressing time have the greatest influence on the briquette strength, and its composition, i.e., the ratio of leaves and waste paper in the feedstock, has the greatest influence on the lower calorific value
The development a fully-balanced current-tunable first-order low-pass filter with Caprio technique
Authors: Lertkonsarn Samran , Sa-ngiamvibool Worawat
Published: October 2022

This paper presents the development and design of a fully-balanced current-tunable first-order low-pass filter with Caprio technique, which could include the design and implementation of a first-order low-pass filter circuits. The filter consists of six bipolar junction transistor (BJT) and a single capacitor. The filter construction uses a bipolar junction transistor (BJT) as the main device and a single capacitor. A fully-balanced current-tunable first-order low-pass filter with Caprio technique developed. The architecture of the circuit is quite simple and proportional, symmetrical with signs of difference. Circuits developed into integrated circuits act like basic circuits for frequency filter circuits, current modes with Caprio techniques, obtained by improving the first-order low-pass filter for signal differences with incoming impedances. Adjusting the parameters of the circuit with the caprio technique achieves the optimal parameter value for correcting the total harmonic distortion value.

The results of testing the operation of the circuit, a fully-balanced current-tunable first-order low-pass filter with Caprio technique developed and designed using the PSpice program. The simulation results showed good results in line with predicted theoretical analysis. The sensitivity of the device to the center frequency (ω0) response is low and independent of variables, the angular frequency is linear with wide current adjustment throughout the sweeping range of a wide frequency range, with a wide range of over tree orders of magnitude. Therefore, fully-balanced current-tunable first-order low-pass filter developed is very suitable to apply various applications regarding low frequency signal filtration, for example in biomedical systems, for example.
Principal component analysis as tool for data reduction with an application
Authors: Latif Shereen Hamdy Abdel , Alwan Asraa Sadoon , Mohamed Amany Mousa
Published: October 2022

The recent trends in collecting huge datasets have posed a great challenge that is brought by the high dimensionality and aggravated by the presence of irrelevant dimensions. Machine learning models for regression is recognized as a convenient way of improving the estimation for empirical models. Popular machine learning models is support vector regression (SVR). However, the usage of principal component analysis (PCA) as a variable reduction method along with SVR is suggested. The principal component analysis helps in building a predictive model that is simple as it contains the smallest number of variables and efficient. In this paper, we investigate the competence of SVR with PCA to explore its performance for a more accurate estimation. Simulation study and Renal Failure (RF) data of SVR optimized by four different kernel functions; linear, polynomial, radial basis, and sigmoid functions using R software, version (R x64 3.2.5) to compare the behavior of ε SVR and v-SVR models for different sample sizes ranges from small, moderate to large such as; 50, 100, and 150. The performance criteria are root mean squared error (RMSE) and coefficient of determination R2 showed the superiority of ε-SVR over v- SVR. Furthermore, the implementation of SVR after employing PCA improves the results. Also, the simulation results showed that the best performing kernel function is the linear kernel. For real data the results showed that the best kernels are linear and radial basis function. It is also clear that, with ε-SVR and v-SVR, the RMSE values for almost kernel functions decreased with increasing sample size. Therefore, the performance of ε-SVR improved after applying PCA. In addition sample size n=50 gave good results for linear and radial kernel
Driving private sector credit in Nigeria: The role of growth finance
Authors: Hassan Bello , Osabuohien Evans , Ayadi Folorunso , Ejemeyovwi Jeremiah , Okafor Victoria
Published: October 2022

There is some level of uncertainty as to whether private sector credit interacts with finance sources for growth to significantly influence channeling funds for investible purposes in Nigeria, given the nation’s unique characteristics. This study examines the role of various sources of growth finance on private sector credit in Nigeria. For this purpose, the study utilizes secondary data (1980–2018) sourced from CBN statistical annual reports. The study further employs the ARDL-Bounds Co-integration test to test out the hypothesis after stationarity testing. The study finds that stock market capitalization had a positive and significant influence on private sector credit compared to remittance inflows and gross domestic savings in the long run among the sources of growth finance indicators. Furthermore, remittance inflows reported a positive but statistically insignificant relationship, while gross domestic savings had a negative and insignificant coefficient. The study concludes that only stock market development inflow transmits to the private sector’s credit at 10 percent among the various growth finance sources.
ТЕХНОЛОГИИ СОЦИАЛЬНОГО СОПРОВОЖДЕНИЯ, ПРОФОРИЕНТАЦИИ И ТРУДОУСТРОЙСТВА ВЫПУСКНИКОВ С ОВЗ МЕДИЦИНСКОГО УНИВЕРСИТЕТА
Authors: Шульгина Т.А. , Литнарович Н.Е.
Published: October 2022

The article presents the results of a study of the technology of social support, career guidance and employment of graduates with disabilities of a medical university.
Modelling negotiations on the Nordic Economic Area: Uncertainty and absolute gains as factors of international solidarity
Authors:   St. Petersburg State University, Lanko Dmitry
Published: October 2022

The article revisits the negotiations on NORDEK, a Nordic Economic Area, held by Denmark, Finland, Iceland, Norway and Sweden in 1968–1970. Finland, which initially took active part in the negotiations, later reversed its position under pressure from the Soviet Union as well as for other reasons. Four remaining Nordic countries refused to pursue a Nordic Economic Area without Finland for multiple reasons, of which one was solidarity with Finland. This article presents multiple game models, of which some reflect the actual outcome of the NORDEK negotiations, i. e., their failure, while others reflect hypothetical outcomes of the negotiations, such as emergence of a NORDEK of four without Finland. Those models allow concluding on the main factors causing Nordic solidarity, for which the NORDEK negotiations were a testing ground, and which had been the defining feature of regional politics in the European North during fifty years following the failure of the negotiations. First, domestic uncertainty about the issue debated by multiple nations contributes to greater solidarity among those nations. Second, majority’s focus on their absolute gains during international negotiations contributes to greater solidarity among negotiating nations. Third, relative equality among negotiating nations does not have any influence on solidarity among them. The latter conclusion supports the theoretical assumption that that organic solidarity (solidarity among different) is as possible as is mechanical solidarity (solidarity of similar).
“The Sun is also a star”: The foreign policy issue in the Republic North Macedonia EU-integration
Authors:   St. Petersburg State University, Koloskov Evgenii
Published: October 2022

The article is devoted to the foreign policy aspect of the EU-integration of the Republic of North Macedonia. The main attention of the article is paid not only to the interaction of official Skopje and Brussels, but also to the problems of the regional dimension of integration processes. Three main regional challenges for Macedonia are considered: the Macedonian name dispute, the Political views on the Macedonian language and the Albanian issue. The last one is not only about the rights and claims of the Albanian community of the country, but also It is the issue which seriously affecting Macedonia bilateral relations with neighboring Albania, the so-called “Republic of Kosovo”, Serbia and Montenegro. In the course of the study, the main contradictions of the parties were analyzed, the stages of the integration process of Macedonia in relation to NATO and the EU were highlighted, and a forecast was made regarding the prospects of the Skopje state to leave the top ten applicants and become a full member of the EU. Based on the results of the study, we came to the conclusion that in the future it is equally likely that both the successful resolution of existing conflicts in the case of a new focus of Brussels on the problems of the Western Balkans, and the freezing of existing contradictions and, even, under certain circumstances, the resumption of seemingly subsided memory wars, as this happened with the Political views on the Macedonian language in Macedonian- Bulgarian relations.
Discrediting bullying in online dialogues (on the material of linguo expert practice)
Authors:   Altai State University, Chernyshova Tatyana V.
Published: October 2022

This article presents the results of the study — discrediting cyberbullying in the polylogues of network communication. The purpose of the study is to describe the options for the formation of defamatory cyberbullying in network communication and to identify some of its typological features in comparison with conflicting texts of a defamatory orientation in the materials of traditional print media based on the material of controversial texts that became the object of litigation in 2019–2021. The study, conducted on the material of three types of aggressive verbal behavior of network communicators — SMS correspondence, chat in the WhatsApp messenger and personal correspondence in the same messenger, made it possible to clarify some typological features of cyberbullying varieties as a distinct social problem that requires discussion and search for solutions. A comparative analysis of public aggressive speech actions associated with an attempt to discredit an opponent in traditional media (media) and social messengers made it possible to identify their common and different features. The common features, united by the strategy and tactics of discrediting, include: purposeful and pre-planned choice of the victim, due to the situation of communication, goals, the implementation of which is pursued by discrediting or offensive actions; conventionally or legally fixed rules of speech behavior in public and private speech communication. The differences, in our opinion, are primarily due to the type of discourse (institutional, interpersonal or mixed), the form of language manifestation as a means of communication (written/printed, oral, electronic); addressee factor (the number of participants involved in a speech conflict or observing it); a set of linguistic and non-linguistic means selected for cyberbullying. We believe that modern mass media serve as a kind of standard for the selection of speech means of communication, not only in “real”, but also in modern virtual communication.
Dialogue in Slovak social networks
Authors:   Comenius University in Bratislava, Orgoňová Oľga , Kazharnovich Maryna P. ,   Comenius University in Bratislava
Published: October 2022

In the conditions of widespread informatization of the communicative space, a new paradigm of communication is gradually being formed. The paradigm can be defined as interactive. In the modern world, virtual communication in social networks has become an integral part of the functioning of society and individuals themselves. Often it is not one of the possible forms of communication, but absolutely the main one — both private and institutional. The fundamental principle of network culture is its installation on communication, interaction, dialogue. The virtual network largely repeats the practices of natural social life, but at the same time forms an alternative network society. A decentered, non-hierarchical and open networked society provides its own system of values, norms and rules of speech behavior, methods of communication, its own communication formats, principles of organization and functioning, in other words, its own culture of dialogue. The focus of this article is the discourse of everyday life in social networks, in which spontaneous second-type dialogue prevails. Such a dialogue is characterized by informality, linguistic improvisation, interdiscursivity, a combination of attributes of oral and written speech. On the basis of the analysis of the methods and speech features of the implementation of communication in the social networks, the general and private (due to the characteristics of the social network as a dialogue platform) features of the virtual dialogue through the prism of its participants (virtual “I”, identities) and the forms of their speech interaction (post and comment) are identified. The image of an authentic dialogue in a social network as a verbal-nonverbal behavior of its participants is formed by analyzing subjective speech acts in combination with their non-verbal discursive action. The article is based on the report that is going to be presented at the XVIII International Congress of Slavists in 2025.
Evaluating The hydrological response due to the changes in climate and land use on streamflow in the Karkheh basin, Iran
Authors: Chegnizadeh Alireza , Rabieifar Hamidreza , Ebrahimi Hossein , Nayeri Mahmoud Zakeri
Published: October 2022

The Karkheh basin is one of Iran's largest and most waterlogged rivers. In this study, we aim to analyze the impact of Climate change and landuse change on the Karkheh basin using the Soil and Water Assessment Tool (SWAT). In this research, the considered land-use change is based on Iran's future policies, and climate change is studied by employing the RCP series and GCM in Mid-term (2040–2060) and Long-term (2080–2100). Firstly, changes in climate and land use are separately examined, and then the simultaneous impact of these two parameters is investigated. The results of the climate change study illustrate that the highest rate of change, which is a decrease of 14.3–22.8%, is achieved from the RCP 8.5 series in the long term. The results obtained from investigating the land-use change based on future policies in Iran show a maximum reduction of 7% in the average monthly runoff. The flow rate also decreases further when considering the simultaneous effects of both changes in the basin. In this case, the RCP 8.5 series shows a reduction of up to 39% in the long term. This study suggests that the effects of climate change are more significant than changes in landuse.
An O-phosphotyrosine-containing analogue of human angiotensin ii exhibits increased serum stability
Authors: Wadel John D , Perich John W , Tregear Geoffrey W , Szendrei Gyorgyi I , Jr. Laszlo Otvos
Published: October 2022

Synthetic human [Tyr (P)]4-angiotensin II was analyzed by CD spectroscopy and compared with
native human angiotensin II. The data showed there to be no apparent conformational difference between the
two peptides in both aqueous and graded TFE solutions. An assessment of the in vitro stability of the two
peptides to serum proteases showed clearly that the O-phosphorylated angiotensin II was more resistant to
enzymic degradation suggesting that the tyrosyl O-phosphate plays a significant role in inhibiting this process.
Calculation of the proton chemical shifts as a tool to explain the peculiarities of 1H NMR spectra of protein in a compact denatured state
Authors: Kivaeva Lilly S. , lbragimova Gulshat T. , Kutyshenko Victor P.
Published: October 2022

Using the protein crystal structure the chemical shift dispersi<ms of binase a-CH protons were calculated for
protein in native state and in a compact denatured one. The same models of internal fields with different
adjusting parameters were used to describe data for protons disposed in regions of both regular and irregular
secondary structures. It was shown that peculiarities of 1H NMR spectra, bserved for compact denatured
proteins, could be explained through fluctuations of hydrogen bonds network in conserved secondary structures.
Crystallization and preliminary x-ray analysis of triosephospha te isomerase from trypanosoma cruzi
Authors: Gomez-Puyout Armando , Maldonado Ernesto , Moreno Abel , Panneerselvam Kaliyamoorthy , Ostoa-Saloma Pedro , Garza-Ramos Georgina , Soriano-Garcia Manuel , Perez-Montforti Ruy , de Gomez-Puyou Marietta Tuena
Published: October 2022

Recombinant triosephosphate isomerase from Trypanosoma cruzi was crystallized at room
temperature from 0.1 M Na Hepes pH 7.5, 2 % (v/v) PEG 400 and 2.0 M ammonium sulfate. Crystals belong to
the orthorhombic space group P212121with cell dimensions a= 43.71A, b = 77.65A, c = 149.54A, and a= p = y
= 90°. Another crystal with cell dimensions a= b = 56.16A, c = 161.85A, and a= P = y = 90° with two possible
tetragonal space groups P41212 or P43212 was obtained. Both crystals diffract up to I.86 A.
Crystallization and preliminary x-ray crystallographic studies of dutpase from equine infectious anemia virus
Authors: Persson Rebecca , Rosengren Anna Maria , Nyman Per Olof , Dauter Zbigniew , Cedergren-Zeppezauer Eila
Published: October 2022

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase), an enzyrrie in the nucleotide metabolism, from the retrovirus Equine Infectious Anemia Virus (EIAV) has been crystilllized from PEG mixtures at
neutral pH using a vapour diffusion method. Crystals of native enzyme belong to the space group R32, while
crystals formed in the presence of Sr2+ and dUDP, a substrate analogue, belong to the space group P4132 or
P4332. Both forms are suitable for high resolution X-ray structure analyses.
The effect of truncation on shk toxin:• elimination of the amino-carboxyl
terminal (3-35) disulfide linkage stabilizing the amino and carboxyl terminal segments
Authors: Pennington M.W. , Mahnir V.M. , Baur P. , McVaugh C.T. , Behm D. , Kem W.R.
Published: October 2022

We have synthesized two truncated analogs of ShK toxin which contain the main residues comprising the binding surface of the toxin. In both of these analogs, the disulfide bond which links the N and C terminal Cys residues has been eliminated. The remaining two disulfide bonds (Cys12-Cys28, Cysl 7-Cys32) have been retained in one analog and the other analog contains only the Cys17-Cys32 linkage. The CD spectrum of the bicyclic peptide appears to have a small amount of the helical structure whereas the monocyclic peptide spectrum appears to be disordered. The activity of the bicyclic and monocyclic peptides were respectively reduced by 1360- and >3000-fold relative to wild type ShK toxin.
Human a-fetoprotein is in the molten globule state under conditions modelling protein environment near the membrane surface
Authors: Uversky Vladimir N. , Narizhneva Natalya V.
Published: October 2022

Conformational transitions induced in a-fetoprotein by such organic solvents as methanol and trifluoroethanol were studied using circular dichroism, tryptophan fluorescence spectroscopy and digital scanning calorimetry. The existence of well-populated intermediate state without rigid tertiary structure but with native-like secondary structure content and compactness (i.e., the molten globule-like intermediate state) was established. A possible implication of such structural rearrangement to function of this protein is discussed.
Sequence-specific 1h nmr assignments and secondary structure of neuropeptide y analogs in aqueous solution
Authors: Samarasinghe S. D. , Kar L. , Balasubramaniam A. , Johnson M. E.
Published: October 2022

Solution structures of neuropeptide Y analogs NP158 and NP181 were studied by 1H NMR spectroscopy. Sequential assignments were made at pH 3.5 at 25°C and 45°C using COSY, HOHAHA and ROESY spectra. Modeling shows turn-type loop structures in aqueous solution that could be important for receptor binding and/or antagonistic potency.. No significant conformational differences were observed between the two polypeptides despite vastly different antagonistic potency towards NPY YI receptors.
Crystal structure of myotoxin-11: a myotoxic phospholipase A2 - homologue from bothrops moojenivenom
Authors: de Azevedo W.F. , Ward R.J. , Lombardi F.R. , Giglio J.R. , Soares A.M. , Fontes M.R.M. , Arni R.K.
Published: October 2022

The crystal structure ofMyotoxin-II (MjTX-II), a Lys49 PLAi-homologue from Bothrops moojeni venom has been determined and refined at 2.0 A to a crystallographic residual of 19.7% (Ru.0=28.1%). MjTX-II is a dimer in the crystal, with the monomers in the asymmetric unit related by a two-fold symmetry axis running through the dimer interface. The dimers of MjTX-II and the Lys49 PLA2 from B. asper venom are similar, however the relative orientations of the monomers suggests a flexible dimer interface, which serves as a hinge between the two molecules.
Crystallization and preliminary crystallographic analysis of scilla campanulata lectin complexed with A-D-mannose
Authors: Wright Lisa M. , Wood Stephen D. , Reynolds Colin D. , Rizkallaht Pierre J. , Allen Anthony K.
Published: October 2022

Recently many new lectins have been isolated from monocotyledonous plants which have interesting glycan­ binding behaviour. In this paper we present the crystallization and preliminary X-ray analysis of a lectin, isolated from bluebell (Scilla campanulata) bulbs, complexed with a-D-mannose. The complex crystallizes in space group P21212 with a= 70.73, b = 92.97 and c = 47.07A. Synchrotron X-ray data have been measured at 1.86A resolution and the crystal structure of the complex will be solved by the molecular replacement method.
Simulation of the unfolding of a leucine zipper
Authors: Flanagan Karen , Goodfellow Julia M.
Published: October 2022

Molecular dynamics simulations of the 33 residue coiled-coil domain of the GCN4 leucine zipper GCN4-p1 have been carried out at 298 and 328K. The room temperature simulation correlated well with the findings of Rozelle et al. [l] and is consistent with NMR data [2]. The higher temperature simulation indicates the presence of a conformational substate on the folding pathway. Analysis of breaking of hydrogen bonds and hydrophobic interactions gives information on the order of protein unfolding events.
ORTAOKUL ÖĞRENCİLERİNİN OKULDAKİ TEMEL PSİKOLOJİK İHTİYAÇLARI İLE OKULA BAĞLANMA DÜZEYLERİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: UZUN Mahmut Sami , BAKİOĞLU Fuad
Published: October 2022

Bu araştırmada taşımalı eğitim kapsamında olan ve olmayan öğrencilerin okuldaki temel psikolojik ihtiyaçları ile okula bağlanmaları arasındaki ilişkinin incelenmesi amaçlanmıştır. Betimsel bir araştırma olan bu çalışmada ilişkisel tarama modeli kullanılmıştır. Araştırmanın çalışma grubunu 2020-2021 eğitim öğretim yılında öğrenimlerine devam eden 467 (%61,3)‘si kız ve 295 (%38,7)’i erkek, toplamda 762 ortaokul öğrencisi oluşturmaktadır. Veri toplama aracı olarak Kişisel Bilgi Formu, Ergen Öğrencilerin Okulda Temel Psikolojik Gereksinimleri Ölçeği ve Çocuk ve Ergenler için Okula Bağlanma Ölçeği kullanılmıştır. Verilerin analizinde Pearson korelasyon analizi, bağımsız gruplar için iki yönlü ANOVA ve çoklu Regresyon analizi uygulanmıştır. Bulgulara göre taşımalı eğitim kapsamında olan öğrencilerin okuldaki temel psikolojik ihtiyaç düzeyleri taşımalı eğitim kapsamında olmayan öğrencilerinkinden anlamlı düzeyde düşük bulunmuştur. Dahası okuldaki temel psikolojik ihtiyaçlar öğrencilerin cinsiyetine göre kızların lehine anlamlı düzeyde bulgular elde edilmiştir. Taşımalı eğitim kapsamında olan öğrencilerin okula bağlanma düzeyleri taşımalı eğitim kapsamında olmayan öğrencilerin okula bağlanma düzeylerinden anlamlı düzeyde düşük bulunmuştur. Öğrencilerin okula bağlanma düzeyleri cinsiyetine göre kızların lehine anlamlı düzeyde bulgular elde edilmiştir. Öğrencilerin okuldaki temel psikolojik ihtiyaçları, okul türü ve okula bağlanmaları arasında pozitif yönde anlamlı düzeyde ilişkiler bulunmuştur. Son olarak öğrencilerin okuldaki temel psikolojik ihtiyaçları ve okul türü okula bağlanmalarının toplam varyansının yaklaşık %20’sini açıklamıştır. Sonuçlara göre öğrencilerin taşımalı eğitim kapsamında olmaması ve okuldaki temel psikolojik ihtiyaçlarının karşılanması okula bağlılıklarını arttıracak etmenler arasında sayılabilir.