bluuebunny/crossref_metadata_2025 huggingface dataset:
In SilicoDesign and Synthesis of Targeted Curcumin Derivatives as Xanthine Oxidase Inhibitors
Authors: Malik Neelam , Dhiman Priyanka , Khatkar Anurag
Published: November 2018

Background: Curcumin is a well-known pharmacophore and some of its derivatives are shown to target xanthine oxidase (XO) to alleviate disorders caused by the excess production of uric acid.

 Objective: Curcumin based derivatives were designed, synthesized and evaluated for their antioxidant and xanthine oxidase inhibitory potential.

 Method: In this report, we designed and synthesized two series of curcumin derivatives modified by inserting pyrazole and pyrimidine ring to central keto group. The synthesized compounds were evaluated for their antioxidant and xanthine oxidase inhibitory potential.

 Results: Results showed that pyrazole analogues of curcumin produced excellent XO inhibitory potency with the IC50 values varying from 06.255 µM to 10.503 µM. Among pyrimidine derivatives compound CU3a1 having ortho nitro substitution exhibited more potent xanthine oxidase inhibitory activity than any other curcumin derivative of this series.

 Conclusion: Curcumin derivatives CU5b1, CU5b2, CU5b3, and CU3a1 showed a potent inhibitory activity against xanthine oxidase along with good antioxidant potential.
DNA Methyltransferase Inhibitors and their Therapeutic Potential
Authors: Zhou Zehao , Li Huan-Qiu , Liu Feng
Published: November 2018

Aberrant DNA methylation at the 5-position of cytosine, catalyzed by DNA methyltransferases
(DNMTs), is associated with not only various cancers by silencing of tumor suppressor genes but
also other diseases. The DNMTs, especially the DNMT1, DNMT3A and DNMT3B, are often overexpressed
in various cancer tissues and cell lines. DNMTs are important epigenetic targets for drug development
since the DNA methylation is reversible. This review summarizes an array of nucleoside and
non-nucleoside inhibitors of DNMTs, as well as their biological activities. Among these inhibitors, the
nucleoside analogue azacytidine and its deoxy derivative decitabine are both irreversible DNMT inhibitors
and approved for the treatment of myelodysplastic syndrome.
Intelligently Applying Artificial Intelligence in Chemoinformatics
Authors: Sharma Sahil , Sharma Deepak
Published: November 2018

The intertwining of chemoinformatics with artificial intelligence (AI) has given a tremendous
fillip to the field of drug discovery. With the rapid growth of chemical data from high throughput
screening and combinatorial synthesis, AI has become an indispensable tool for drug designers to
mine chemical information from large compound databases for developing drugs at a much faster rate
as never before. The applications of AI have gone beyond bioactivity predictions and have shown
promise in addressing diverse problems in drug discovery like de novo molecular design, synthesis
prediction and biological image analysis. In this article, we provide an overview of all the algorithms
under the umbrella of AI, enlist the tools/frameworks required for implementing these algorithms as
well as present a compendium of web servers, databases and open-source platforms implicated in
drug discovery, Quantitative Structure-Activity Relationship (QSAR), data mining, solvation free energy
and molecular graph mining.
Endothelial and Cardiac Dysfunction in Inflammatory Bowel Diseases: Does Treatment Modify the Inflammatory Load on Arterial and Cardiac Structure and Function?
Authors: Triantafyllou Charilaos , Nikolaou Maria , Ikonomidis Ignatios , Bamias Giorgos , Papaconstantinou Ioannis
Published: November 2018

Inflammatory bowel diseases (IBD), largely represented by Crohn’s disease (CD) and ulcerative colitis (UC), alter gastrointestinal physiology and mucosal immunity through a complex inflammatory process. These diseases can lead to significant arterial endothelial dysfunction. There is also evidence linking IBD with a modification of cardiac structure and function. A growing body of research has associated IBD with an acceleration of arterial stiffness and atherosclerosis and an increased risk of cardiovascular (CV) morbidity and mortality. The focus of this review is two-fold. Firstly, the literature on IBD in relation to CV dysfunction was evaluated (mainly based on 25 relevant surveys carried out between 2005 and 2018). The vast majority of these studies support a significant association of IBD with a deterioration in CV function. Secondly, the literature available regarding the effect of IBD treatment on CV dysfunction was considered based on studies published between 2007 and 2018. This literature search suggests that IBD treatment may have the potential to ameliorate CV dysfunction resulting in CV benefits. This review will analyse the literature as well as consider emerging research perspectives regarding how IBD treatment could improve CV dysfunction.
Identification of the Altered Proteins Related to Colon Carcinogenesis by iTRAQ-based Quantitative Proteomic Analysis
Authors: Luo Chunhua , Yao Defu , Lim Teck Kwang , Lin Qingsong , Liu Yingfu
Published: November 2018

Background:

The molecular mechanisms or valuable biomarkers for early diagnosis of colorectal cancer (CRC) are not fully elucidated yet.

Objective:

To understand the proteomic changes at the global level in the carcinogenesis of CRC, differentially expressed proteins between normal intestinal epithelial cells CCD841 and colorectal cancer cells HCT116 were identified.

Method:

The isobaric tags for relative and absolute quantitation (iTRAQ) coupled with 2D LC-MS/MS proteomic approach were performed for screening the altered proteins between cells CCD841 and HCT116.

Results:

A total of 1947 proteins were identified after filtering and using a 1% false discovery rate. Based on a final cutoff (> 3.16 and < 0.32), 229 proteins were found to be significantly altered, among which 95 (41%) were up-regulated while 134 (59%) were down-regulated. Gene Ontology analysis revealed that the differentially expressed proteins were mainly cell part proteins involved in cellular process and binding in terms of subcellular distribution, biological process, and molecular function. KEGG analysis indicated that the differentially expressed proteins were significantly involved in the process of focal adhesion, pathogenic Escherichia coli infection, leukocyte transendothelial migration, bacterial invasion of epithelial cells, regulation of actin cytoskeleton, DNA replication and so on.

Conclusion:

Collectively, our data identified differentially expressed proteins in colon cancer carcinogenesis, which could provide the clues on unraveling the molecular mechanism of CRC.
Systemic Lupus Erythematosus: Symptoms and Signs at Initial Presentations
Authors: Metry Abdel Masieh , Al Salmi Issa , Al Balushi Farida , Yousef Mohammed Abdalla , Al Ismaili Faisal , Hola Alan , Hannawi Suad
Published: November 2018

Background:

Systemic Lupus Erythematosus (SLE) is an autoimmune multisystem
inflammatory condition that causes microvascular inflammation with the production of
various auto-antibodies that play a major role in its pathogenesis. SLE can affect both sexes,
all ages, and all ethnic groups with widespread geographical and socioeconomic backgrounds.
Asia encompasses people of many sociocultural backgrounds with diverse ethnic.

Objective:

Due to a lack of national epidemiological research, the incidence and prevalence
of SLE in Middle Eastern and Arab countries, have only recently been studied. This article
aims to explore the status of SLE in Oman and to record symptoms and signs of SLE at first
presentation.

Methodology:

Medical records of all patients diagnosed with SLE at the Royal Hospital from
2006 to 2014 were reviewed for information recorded at first visit. SLE diagnosis was based
on the American College of Rheumatology classification criteria; ACR97 (which includes the
clinical manifestation and laboratory evidence). Patients with SLE disease manifestations extrapolated
and analyzed.

:

There were 966 patients diagnosed with SLE during the period from 2006 to 2014. Mean
(SD) age at presentations was 35.5 (11.5) years. Majority of patients were female which constitutes
88.7% of the total SLE patients with mean age 27.6 (1.4) years.

Results:

Constitutional symptoms were found in 48.68 of SLE population including fatigue in
35.22%, and weight changes in 13.43%.

:

The cutaneous manifestations that were present included malar rash 37.69%, photosensitivity
35.10%, discoid lupus 17.63%, and hair loss 39.29%.

:

Musculoskeletal manifestations were commonly seen among the studied population including
arthralgia in 68.75%, myalgia in 55.65%, arthritis in 48.31%, whilst myositis, tendon abnormalities
and avascular necrosis were found in only 2.47%, 0.31% and 1.98%. respectively.

Conclusion:

This is the first study of the symptoms and signs at initial clinical presentation of
SLE patients compared to other studies done regionally where most have focused on clinical
manifestations during the progression course of SLE. SLE manifestations may be related to
the differences in the genetic make-up of the patients who come from various ethnic groups
despite similar geography or sociocultural background, or to referral bias, as some studies
were performed in the nephrology units and others in the rheumatology units. There is a
pressing need to establish a nationwide and regional collaboration to establish LUPUS and to
put forward a strategic planning with each MOH to provide an easy and efficient report of
SLE cases and provide various effective management for such a debilitating syndrome.
Development and Performance Research of New Small Displacement Pump with Solid Plunger and Non-coaxial Delivery Valve
Authors: Zi-ming Feng , Weibo Duan , Wei Cui
Published: November 2018

Background:

After the oilfield development coming into the middle and later periods,
many oil wells only had liquid production less than 5m3 per day, therefore the present sucker-rod
pumps didn’t satisfy the need for oilfield production. We revised all patents relating to small displacement
pump and didn’t found any suitable pump for low production well. A new type of pump
with small diameter was needed to design for solving the unbalance between the production and feed
in lower production wells.

Objective:

o resolve the problems of supply and production imbalance of the low producing well,
low pump efficiency and low system efficiency, a low displacement pump with non-coaxial delivery
valve had been designed.

Methods:

This type pump adopted a solid plunger, and its delivery valve was not coaxial with the
pump axial that would enhance its structural strength and been useful to reduce the partial flow loss
of oil flowing through the static pump valve. At the down dead point of pump plunger, the delivery
valve was located at the top of the pump chamber that was to the benefit of discharge of the gas and
the oil from the pump chamber. The uneven distribution of the delivery hole was suitable for the
wellhead diameter of the traditional oil wells.

Results:

The delivery valve was non-coaxial with the plunger that would decrease the flow loss
through the passage and increase the pump efficiency. At the down-dead point, the plunger entered
the extension nipple, and the delivery valve was located up the end of the solid plunger that promoted
the remnant gas flowing out of the pump cylinder and decreased the effect of gas on the pump efficiency.

Conclusion:

As to this low displacement pump, we suggested: The suitable stroke was 2-3m; the
stroke frequency was less than 3min-1. A reasonable range of submersible depth for low production
well was 200-300m. It was used in the gas content well lower than 20%, else used the gas anchor
firstly. The low displacement pump with non-coaxial delivery valve and solid plunger (NLDP) can
improve the pump efficiency and reduce the polish rod load. At the same time, this NLDP provides
new equipment for the production of the low oil well and improves the artificial lift design theory.
Utility of Molecular Imaging with 2-Deoxy-2-[Fluorine-18] Fluoro-D-Glucose Positron Emission Tomography (18F-FDG PET) for Small Cell Lung Cancer (SCLC): A Radiation Oncology Perspective
Authors: Sager Omer , Dincoglan Ferrat , Demiral Selcuk , Uysal Bora , Gamsiz Hakan , Elcim Yelda , Gundem Esin , Dirican Bahar , Beyzadeoglu Murat
Published: November 2018

Background and Objective:

Although accounting for a relatively small proportion of all lung
cancers, small cell lung cancer (SCLC) remains to be a global health concern with grim prognosis. Radiotherapy
(RT) plays a central role in SCLC management either as a curative or palliative therapeutic strategy.
There has been considerable progress in RT of SCLC, thanks to improved imaging techniques leading
to accurate target localization for precise delivery of RT. Positron emission tomography (PET) is increasingly
used in oncology practice as a non-invasive molecular imaging modality.

Methods:

Herein, we review the utility of molecular imaging with 2-deoxy-2-[fluorine-18] fluoro-Dglucose
PET (18F-FDG PET) for SCLC from a radiation oncology perspective.

Results:

There has been extensive research on the utility of PET for SCLC in terms of improved staging,
restaging, treatment designation, patient selection for curative/palliative intent, target localization,
response assessment, detection of residual/recurrent disease, and prediction of treatment outcomes.

Conclusion:

PET provides useful functional information as a non-invasive molecular imaging modality
and may be exploited to improve the management of patients with SCLC. Incorporation of PET/CT in
staging of patients with SCLC may aid in optimal treatment allocation for an improved therapeutic ratio.
From a radiation oncology perspective, combination of functional and anatomical data provided by
integrated PET/CT improves discrimination between atelectasis and tumor, and assists in the
designation of RT portals with its high accuracy to detect intrathoracic tumor and nodal disease. Utility
of molecular imaging for SCLC should be further investigated in prospective randomized trials to acquire
a higher level of evidence for future potential applications of PET.
Dendrocalamus strictus Charcoal: An Efficient Adsorbent for Removal of Cu (II) Ions from Aqueous Solution and its Applicability in the Reduction of Genotoxic Potential of Cu (II) Ions
Authors: Saini Saraswati , Katnoria Jatinder Kaur , Kaur Inderpreet
Published: November 2018

The present study pertains to evaluate the efficiency of Dendrocalamus strictus charcoal powder as an adsorbent to adsorb copper ions from aqueous solution under different conditions of pH, initial metal ion concentration, adsorbent dose, contact time, and temperature. Physical characterization of Dendrocalamus strictus charcoal powder was performed using different techniques such as scanning electron microscopy, scanning electron microscopy‐energy dispersive X‐ray spectroscopy, Brunauer Emmett and Teller surface analysis and X‐ray diffraction. Langmuir, Freundlich, and Temkin isotherm models were employed to describe the adsorption behavior of adsorbent in the removal of copper ions from aqueous solution. Thermodynamic parameters indicated that the adsorption of copper ions onto the surface of the adsorbent was feasible, spontaneous, and endothermic in nature. Data analysis using kinetic models revealed the pseudo‐second‐order as the suitable model to describe the process of adsorption. Studies were further carried out to analyze the genotoxic effects of copper ions in aqueous solution before and after adsorption, using Allium cepa assay. This study revealed that Dendrocalamus strictus charcoal powder could be applied as an alternative for more costly adsorbents in the detoxification of copper ions from aqueous solution.
Diversity of the Crinocheta (Crustacea, Isopoda, Oniscidea) from Early Miocene Chiapas amber, Mexico
Authors: Broly Pierre , Serrano-Sánchez María De Lourdes , Vega Francisco J.
Published: November 2018

Currently, the Onisicdea (terrestrial isopods) is a massive Crustacea suborder of more than 3 700 species, but our knowledge of their paleodiversity is poor. In this paper, we present ten fossils of Crinocheta, the largest clade within the Onisicdea, discovered in Early Miocene (23 Ma) amber of Chiapas. We described three new genera and six new species including Palaeolibrinus spinicornis gen. nov. sp. nov., Armadilloniscus miocaenicus sp. nov., Archeostenoniscus robustus gen. nov. sp. nov., Archeostenoniscus mexicanus sp. nov., Palaeospherarmadillo mazanticus gen. nov. sp. nov., and Palaeospherarmadillo rotundus sp. nov. This study represents the first fossil record of the family Detonidae, Olibrinidae, and “Stenoniscidae”. From a paleoenvironmental reconstruction perspective, the oniscidean fauna presented here supports a particularly wet paleoenvironment, under brackish water influence, similar to an estuary.
Dinámica costera y antropización en playas uruguayas: un análisis integrado para su conservación Título condensado: Dinámica costera y antropización, Uruguay
Authors: Boretto Gabriella M. , Rouzaut Sabrina , Cioccale Marcela , Gordillo Sandra , Benitez Yanina
Published: November 2018

Los ambientes costeros están siendo afectados a escala global por una excesiva urbanización, crecimiento industrial y turismo, generando erosión, pérdida de biodiversidad y alteración del ecosistema; estas alteraciones constituyen potenciales riesgos con consecuencias negativas tanto ambientales como socioeconómicas. El sector litoral uruguayo, caracterizado por amplias playas de arenas separadas por promontorios rocosos, no es ajeno a esta problemática mundial. Considerando aspectos geomorfológicos, sedimentológicos y malacológicos se pretende comprender el impacto antrópico en la dinámica litoral para contar con una base de datos que sirva para evaluar el manejo del recurso playa. Para ello se compararon siete playas del Departamento Maldonado, una de las cuales se encuentra en el ambiente estuarial mientras que las demás están sobre el margen atlántico, con distintos grados de antropización y urbanización. A través del análisis geomorfológico, haciendo uso de imágenes satelitales, modelos digitales de elevación, procesamiento y almacenamiento de datos en un sistema de información geográfico, se parametrizó cada subambiente costero (mesoplaya, supraplaya, duna y duna modificada) teniendo en cuenta área, ancho, pendiente y perfil transversal en cada sitio. El análisis granulométrico permitió caracterizar cada localidad y cada subambiente; mediante estadística se pudo establecer una relación entre el aumento de la desviación estándar y la antropización en la franja litoral. La composición faunística particularizó cada playa, además mediante el cálculo de distintos índices se identificaron los sitios con mayor diversidad y dominancia. Se determinó que la antropización en la franja costera mediante incipiente desarrollo urbanístico modifica el sector de dunas generando una reducción de todos los subambientes, exponiendo zonas más vulnerables a la erosión inducida. Se espera que este trabajo sea útil en la planificación del ambiente litoral e identificación de zonas críticas.
Explorando un marco de referencia para la caracterización de bioempresas del sector acuícola en Baja California
Authors: Pérez Núñez Sylvia Mónica , Mungaray Moctezuma Ana Bárbara , López-Leyva Santos
Published: November 2018

En el contexto de la economía del conocimiento, los avances científicos generados por la biología y la genética molecular han contribuido al surgimiento del sector biotecnológico conformado por empresas que utilizan biotecnología o “bioempresas”. Conocer la intensidad de este sector implica un reto metodológico por la poca homologación en los criterios de caracterización y medición de intensidad. La propuesta de esta investigación es utilizar los elementos comunes encontrados en los niveles internacional y nacional para construir un marco de referencia. Una vez identificados, centramos nuestra atención en el sector acuícola de Baja California y utilizando estos criterios se establece una caracterización del sector de acuerdo a la clasificación de la empresa como usuaria o desarrolladora de biotecnología, el recurso humano, su vinculación con actores públicos y privados, y la innovación. Además, se establece la intensidad del sector en términos de crecimiento empresarial. La evidencia que encontramos señala que las características de las empresas acuícolas bajacalifornianas responden a los elementos comunes y a la dinámica global del sector biotecnológico.
Colaboraciones y flujos de conocimiento en patentes del sector solar fotovoltaico después del ADPIC
Authors: Palacios-Núñez Guadalupe , Vélez-Cuartas Gabriel Jaime
Published: November 2018

La innovación ahora es un proceso internacional, que requiere una gobernanza global del conocimiento, la cual se estableció en 1994 con la firma del Acuerdo sobre los Aspectos de los Derechos de Propiedad Intelectual relacionados con el Comercio (ADPIC). Uno de los fines de este nuevo régimen de propiedad intelectual es impulsar la innovación como resultado del incremento en las colaboraciones y la revelación del sistema de patentes. El objetivo de este trabajo fue determinar si se incrementaron las colaboraciones y los flujos de conocimiento en las patentes del sector solar fotovoltaico; para esto se utiliza el Análisis de Redes Sociales (ARS) de coautorías y citas, en dos momentos, antes de la firma del acuerdo (1976-1996) y después de la firma del acuerdo (1996-2016). Los resultados muestran que las colaboraciones y los flujos de conocimiento aumentaron principalmente en los países con trayectorias tecnológicas en el sector, tanto a nivel doméstico como internacional.
Populismo: conceptos, vocabularios y experiencias
Authors: Rabotnikof Nora
Published: November 2018

El trabajo parte de reconocer la dificultad de trazar una frontera nítida entre una caracterización conceptual académica especializada y el uso profano (como herramienta en la lucha político-ideológica) del término populismo. En la primera parte abordo el estatuto problemático del término populismo como concepto político y la valencia peyorativa que siempre lo ha acompañado. En la segunda parte, hago un breve recorrido por tres experiencias históricas que fueron en su momento caracterizadas como “populistas”. En la última parte, expongo mis dudas acerca de la posibilidad de revertir esa carga peyorativa adherida al populismo y mi escepticismo frente a los esfuerzos por utilizarlo como un contraconcepto clasificatorio de unidades políticas de acción, tal como se lo ha utilizado para evaluar, en general positivamente, la innovación política llevada a cabo en las experiencias latinoamericanas recientes.
MENJADI IBU HEBAT UNTUK MENURUNKAN PENOLAKAN IBU TERHADAP ANAK DENGAN GANGGUAN SPEKTRUM AUTIS (GSA)
Authors: Purwaningrum Devia , Wahyuningsih Hepi , Nugraha Sumedi P
Published: November 2018

Abstrak. Sikap penerimaan ibu merupakan faktor penting dalam pengasuhan terhadap anak dengan gangguan spektrum autis (GSA). Ibu yang memiliki penerimaan yang tinggi mampu mengembangkan pengasuhan yang positif dan anak mampu berkembang secara optimal. Tujuan dari penelitian ini untuk mengetahui psikoedukasi Menjadi Ibu Hebat untuk menurunkan penolakan terhadap anak dengan GSA. Partisipan adalah tiga ibu yang memiliki anak dengan GSA. Pengumpulan data menggunakan parental acceptance-rejection scale (PARQ). Desain penelitian menggunakan quasi eksperimen one-group pretest-posttest. Analisis data dilakukan uji Friedman Test. Hasil uji statistik dengan uji Friedman Test menunjukkan bahwa tidak ada perbedaan yang signifikan antara sebelum dan sesudah diberikan penanganan, q =1,000, nilai signifikansi 0,607 (p>0,05). Kata kunci: Psikoedukasi, Penolakan Orangtua, Gangguan Spektrum Autis (GSA) Abstract. Mother acceptance is an important factor in caring for children with autism. A mother that has a high acceptance is capable of developing a positive parenting skill and as a result the children are able to grow optimally. This research aimed to examine the psychoeducation to be a great mother to reduce the rejection towards children with autism. The participants were three mothers who have children with autism. Data collection used the parental acceptance-rejection scale (PARQ). The study design using the experimental quasi of one-group pretest-posttest. Data analysis was conducted through the Friedman Test. The result of statistical test with Friedman Test showed no significant difference between before and after the treatment, q = 1,000, and significance value 0,607 (p> 0.05).  Key words: Psychoeducation, rejection, parents, autism spectrum disorder (ASD).
Standardization of highway construction delay claim analysis: A highway bridge case study
Authors: Mehany Mohammed S. Hashem M , Grigg Neil S
Published: November 2018

Highway construction efficiency is critical to highway users such as the trucking industry given today’s era of shortages in funding, and given the need for major re-investments in the highway system. One topic that can add to project costs relates to delays and how contractors are reimbursed for such delays. Delays are common in construction, especially in complex heavy highway and other infrastructure projects, and the claims they generate have negative effects on project schedules and costs. In spite of this, the analysis of claims is hindered due to the variety of methods and analysis techniques in use and lack of standardization in the incorporation of delay claim analysis methods in construction contracts. This paper reviews different methods for delay claim analysis and outlines their advantages and disadvantages. A case study of a bridge project is used to demonstrate the potential for manipulation by using different methods for the same delay case. The analysis shows clearly that a standardized process for delay claim analysis would improve highway construction contracting. Research needs to create a standardized process are outlined.
Business Intelligence as a Source of Competitive Advantage in SMEs: A Systematic Review
Authors: English Vincent , Hoffmann Markus
Published: November 2018

Competitive advantage is the ‘Holy Grail’ in strategic management theory. What makes a company more successful than its rivals has dominated scholarship in this area for more than 20 years. There have been two main theories proposed to attempt to identify the important resources and capabilities that configure to build competitive advantage; the Resource-based View and Dynamic Capability View. There is a growing literature stream in the area of Business Intelligence (BI) and Big Data Analytics with regard to both the computer technology and business management constructs. However, the literature is silent of the affordances of BI for Small to Medium Enterprises (SMEs), and so a significant gap in the literature remains. This discussion aims to signal the need to fill that gap and to build awareness of BI as a potentially significant contributor to sustained competitive advantage in SMEs underpinned by the iniquitousness of cloud applications previously the domain of Multinational Corporations.
The relationship between the psychological space of actors and their hardiness (based on a survey of railway employees)
Authors:   Russian State Agrarian University –  Moscow Timiryazev Agricultural Academy, Pyatun Darya Eduardovna
Published: November 2018

The paper analyzes the formal and substantive structural aspects of the psychological space (the real and ideal vision of life) of station masters on duty. The phenomenon of psychological space is theoretically analyzed; a methodical procedure for studying the aspects of the psychological space of the actor is tested. The research examines the structural features of the psychological space of respondents based on the empirical material collected in the Moscow-Smolensk Railway Station Management Center. The study discusses the relationship of the structure of psychological space with the indicators of personal potential identified by different techniques, in particular, the relationship between the features of psychological space and the level of hardiness. The pilot study findings reveal that the real and ideal psychological spaces differ in simple/complex characteristics and one-dimensional/multi-dimensional structure.
The aspects of STEM Preschool Curriculum Design Module for Bachelor’s Degree students majoring in Teacher Education
Authors:   Moscow City Teachers’ Training University, Zubenko Natalia Yurievna , Sukhova Elena Ivanovna ,   Moscow City Teachers’ Training University
Published: November 2018

Summary: The research summarizes the modern approaches to STEM education: the problem-based learning activities, the integration of STEM subjects, the introduction of innovation to teaching methods in relation to each subject, the multidisciplinary approach to STEM education that implies the integrative environment for teaching STEM subjects. The study presents the content-related and structural characteristics of STEM Preschool Curriculum Design Module for Bachelor’s Degree students: targets, approximate educational outcomes, content, final assessment, focus areas (didactic system of F. Froebel, experiments in animate and inanimate nature, mathematical development, LEGO design, robotics, animation studios), arrangements, and preschool curriculum design methods provided by STEM techniques. The research describes the hands-on experience of involving teachers-to-be in creating STEM projects for preschool students.
The management model of the socio-educational project
Authors:   N.I. Lobachevsky State National Research  University of Nizhny Novgorod, Bylinskaya Alla Aleksandrovna , Ambartsumyan Roman Mikhailovich ,   N.I. Lobachevsky State National Research  University of Nizhny Novgorod
Published: November 2018

The study analyzes the construction and implementation of the socio-educational project model intended to solve social problems through the educational technology. The model is implemented in four stages: inception, design, correction, and release. Each phase implies the specific organizational development tools: Future Search, Conference, Strategic Visioning, Open Space, and Participative Design Workshop. The socio-educational project is devised at the first two stages while it is tested and finally approved at the third and fourth stages. The model test is presented by a case study of AkademiUm project, the interactive and educational platform for the famous citizens of Nizhny Novgorod and visitors to it (scientists, representatives of cultural, arts, and sports industries) to deliver free TED sessions, lectures/seminars.
The value of justice in the modern Russian society: a sociological analysis
Authors:   Belgorod State National Research University, Davtyan Dianna Vazgenovna
Published: November 2018

The research analyzes one of the fundamental values of any society that is social justice. The study substantiates the thesis that the value of justice can act as an incentive for civil actions primarily due to specific social and cultural nature of Russia. Justice in modern sociology is not only the value and an ideal but also the cognitive category serving as the explanatory principle. The study notes that the idea of justice still remains the key one in the value system of the Russian society and belongs to top three values (after trust and responsibility) that are essential for society from the citizens’ perspective. At the same time, despite the fact that there is a high demand for social justice, people are not ready to fight for it. They prefer to be bystanders and hold state or municipal authority and various institutions of civil society responsible for promoting justice.
Youth subcultures as a form of social and cultural adaptation in a marginal situation
Authors:   Herzen State Pedagogical University of Russia, Tsyplakova Olga Gennadievna
Published: November 2018

The study analyzes various circumstances contributing to the emergence of youth subcultures. Such circumstances include the phenomenon of risk society, the diverse social instability, exclusion, deprivation, and discrimination resulting in increased marginalization among young people. There is a tendency to merge marginalized youth into subcultural communities. Subcultures reflect the subjective response of young people to objective public demands and are the specific ways to adapt to social conditions. These conditions can be differently manifested in subcultures: they are either accepted or rejected by young people. The author identifies the escapist, activist, and adaptive subcultures, analyzes their adaptive capacities, and concludes that escapist subcultures are a form of adaptation to a marginal state through the escape from reality. Activist subcultures respond to exclusion by trying to change the social situation. Adaptive subcultures choose adaptation strategies that lead either to stress and over-exploitation or to giving up a career and the pursuit of comfort.
The theoretical grounds and targets and assessment of educational outcomes in the non-formal education of children
Authors:   Kuban State University, Ignatovich Vladlen Konstantinovich , Valentina Evgenyevna Valentina Evgenyevna ,   Kuban State University, Ignatovich Svetlana Sergeevna ,   Kuban State University
Published: November 2018

The research analyzes the present-day targets and assessment practices of students’ educational outcomes in the field of non-formal education of children. This analysis is carried out in the context of three basic ideas about the essence of the educational outcome: 1) as a standard learned by students; 2) as a mode of action mastered by them to solve specific tasks; 3) as an opportunity to make the independent progress towards the individual educational path The educational program used in the non-formal education of children and the instructions to develop it are reviewed from these perspectives. The research presents the findings of a survey of non-formal educators conducted to study their views on the essence of the educational outcome as an educational phenomenon, the subjects of its targets and assessment, the sources of knowledge, and the nature of difficulties faced by teachers when implementing educational programs.
MODEL EDUKASI BERDASARKAN SEGMENTASI KONSUMEN UNTUK MEMBANGUN MINAT MASYARAKAT PADA PERBANKAN SYARIAH
Authors: Waluyo Bambang , Rozza Sylvia , Sujarwo Sujarwo
Published: November 2018

Pemahaman masyarakat yang rendah terhadap perbankan syariah menjadi tantangan tersendiri dalam pengembangan perbankan syariah di Indonesia. Tujuan penelitian mengetahui variasi pelaku segmentasi konsumen dengan memperhatikan aspek-aspek kognitif, sosial, emosional, fisik, estetika dan spiritual. Metode penelitian adalah deskriptif kualitatif. Penelitian terdahulu menemukan lima segmen konsumen yaitu syariah loyalis, obligatory, follower, functional benefit, dan essentially conventional. Ranking pemahaman terhadap perbankan syariah berdasarkan urutan dari yang paling paham hingga yang paling tidak paham adalah syariah loyalis, obligatory, follower, functional benefit dan essentially conventional. Dasar yang dapat digunakan dalam edukasi perbankan syariah adalah : (1). edukasi perbankan syariah masih sangat diperlukan, (2). Edukasi perbankan syariah perlu dimasukkan dalam kurikulum sekolah, (3). Informasi tentang bank syariah dapat disampaikan melalui iklan pada berbagai media, dan (4). Segmen essentially conventional perlu diberi edukasi baik tentang produk maupun tentang perbankan syariah itu sendiri. Kerjasama diantara para stakeholders sangat diperlukan dalam edukasi perbankan syariah. Evaluasi keberhasilan edukasi dapat dilihat dari meningkatnya awareness segmen essentially conventional pada perbankan syariah.
Assessment for Successful Intelligence: A Paradigm Shift in Classroom Practice
Authors: Vianney Mitana John Mary , Muwagga Anthony Mugagga , Ssempala Cornelius
Published: November 2018

Conventional educational assessments favour individuals who are strong in memory and analytical abilities. This is based on a long-standing theory of a general intelligence (g). Alternative intelligence theories have however revealed that success in life requires skills beyond memory and analytical skills. This article presents an analysis of Sternberg’s theory of successful intelligence. Sternberg defines intelligence as one’s ability to achieve one’s goals in life, given one’s social-cultural context; by capitalising on strengths and correcting or compensating for weaknesses in order to adapt, shape and select environments through a combination of analytical, creative and practical skills. This article is divided into four main parts. It starts with an introduction to the conceptual definition of intelligence. Then it discusses Sternberg’s theory of successful intelligence. Next, it discusses assessment for successful intelligence in a classroom. Finally, it draws conclusions.
PHYLOGENETIC ANALYSIS OF 16S rRNA GENE FRAGMENT OF ANTIBIOTIC-PRODUCING PLS 76 ISOLATE
Authors: Suzanni Mulia Aria , Yolanda Amelya , Saidi Nurdin , Febriani Febriani , Iqbalsyah Teuku Mohamad
Published: November 2018

Exploitation of extremophiles as novel bioactive compounds sources has been increasing. The aim of this study was to evaluate the activity and the class of antibiotic produced by a thermo-halophilic isolate PLS 76, as well as to identify the genotype of the isolate. The activity was determined by a disc diffusion method, while the antibiotic class was determined qualitatively by chemical reactions using ninhydrin, iodine vapour and potassium iodine. The genotype was determined by sequencing the 16S rRNA gene fragment and the phylogenetic tree from the sequence data. The results showed that PLS 76 was a Gram-negative bacterium and able to produce polypeptide antibiotic, which showed a slight activity on E. coli and S. aureus. Sequence alignment of the 16S rRNA gene fragment showed that PLS 76 was most related to Geobacillus kaustophilus. These results may be used to utilise the isolated for further antibiotic study.
BIOACTIVE COMPOUNDS OF SPONGE FOR AQUACULTURE AND POTENTIAL METHODS FOR SPONGE CULTIVATION
Authors: Asaf Ruzkiah , Samsi Andi Nur , Athirah Admi , Paena Mudian
Published: November 2018

Aquaculture is an important sector for Indonesian economic, however, the spreads of diseases during farming remains a problem in developing Indonesian aquaculture. The sponge is known as the source of potential bioactive to combat pathogenic diseases in aquaculture.  However, the intensifying exploitation of wild sponge tends to the depreses population of sponges in nature. This article reviews bioactive originating from sponges and potential methods in developing sponges cultivations under in-situ and ex-situ methodologies.
Pengaruh Logam Berbahaya Terhadap Kualitas Kemasan Plastik
Authors: Supeni Guntarti , Syamsudin Samiha
Published: November 2018

Pengaruh Logam Berbahaya Terhadap Kualitas Kemasan Plastik
PDB, Pertumbuhan dan Pembangunan Ekonomi Di Indonesia
Authors: . Yanuar
Published: November 2018

Gross Domestic Product (GDP) of a country is calculated by using the production approach and influenced by the capital, human resources, natural resources, and entrepreneurship. Indonesia with the four most tremendous amounts of resources in the word has actually a potential to be a rich nation which is able to improve its people walfare. But seen from its GDP aspect, Indonesia is only at number 142 in the word.
Faktor-Faktor Yang Mempengaruhi Kemauan Wajib Pajak Orang Pribadi Untuk Mengikuti Tax Amnesty (Studi Empiris Pada Perguruan Tinggi Di Jakarta Barat)
Authors: Viriany, Yanti Henny Wirianata, Liana Susanto,
Published: November 2018

The purpose of this research was to obtained an empirical evidence about the influence of continuous Government’s campaign, easiness of tax amnesty, tax amnesty’s rate, and tax sanctions on taxpayer’s willingness to enroll tax amnesty. This study use primary data from quesioners. Continuous Government’s campaign measured by 5 questions, easiness of tax amnesty 7 questions, tax amnesty’s rate 7 questions, tax sanctions 2 questions, and taxpayer’s willingnes 4 questions. The respondents were Lecturers in Economic Faculty in Tarumanagara University. This study used statistical tests. The results showed that continuous Government’s campaign and easiness of tax amnesty have sifnificant and positive influence toward taxpayer’s willingness. Meanwhile, tax amnesty’s rate and tax sanctions has no significant influence toward taxpayer’s willingness to enroll tax amnesty.
Analisis Faktor Eksploratori Layanan @syariahmandiri
Authors: Nugroho Arissetyanto
Published: November 2018

The bank competition in Indonesia is high, conventional banks and sharia banks strive to improve competitiveness and gain positioning in the minds of the consumers. Previous research conducted by @bankmandiri compared to @syariahmandiri in 2015 gives the managerial implication that Syariah bank twitter is not as active as a conventional bank. @bankmandiri frequency compared to @syariahmandiri is different. Variety of the service proposition @syariahmandiri is fewer than the variety of service proposition @bankmandiri. The follow-up research is conducted by using the @syariahmandiri tweets data from January to Jul 2016. The data processed with the Provalis Research software, to obtain descriptive frequencies, hashtags, mentions and extracted name entities, cluster analysis, and  to obtain the service proposition of @syariahmandiri. The results show a robust development @syariahmandiri twitter activities, an increasing number of tweet frequencies and varieties of service proposition compare with Jan Des 2015 dataset.
Kinerja Perusahaan Ditinjau Dari Faktor Non Keuangan Dan Struktur Modal
Authors: Bambang Wahyudi Wicaksono Diyan Lestari,
Published: November 2018

This study aims to analyze the performance of food and beverage companies listed on the Indonesia Stock Exchange from the period 2009 to 2016, in terms of non-financial factors consisting of corporate governance as measured by Board Size, Independent Board of Commissioners, Audit Committee, and Concentrated Ownership. Other non-financial factors are innovation which is one of the supporting factors to improve performance. Capital structure plays an important role in improving organizational performance. To analyze the effect on organizational performance in terms of non-financial factors and capital structure, this study uses multiple linear regression with panel data. The results of this study indicate that the Board Size.
Development and Validation of High Performance LCMS Methods for Estimation of Ebastine and Carebastine in Human Plasma
Authors: Nair Sheeba Manoj , P Ravi Kumar , Govindan Balasubramani , . Sanjay , Karia Denish
Published: November 2018

A simple and specific method for simultaneous determination of Ebastine and Carebastine by liquid chromatography-tandem mass spectrometry operated in positive ionization mode was developed and validated. The column used was a BDS Hypersil C18, 50 mm × 4.6 mm, 5µm with a flow rate of 0.6 mL/min, without splitter for the chromatographic analysis with flow rate of 0.6 mL/min. Solid phase extraction method was applied. Mass parameters, 496.2/261.0 and 672.2/479.3/261.2 were chosen for analysis. Linearity was established in human plasma covering the concentration range of 0.051 ng/mL to 31.099 ng/mL for Ebastine and 1.013 ng/mL to 1005.451 ng/mL for Carebastine using (Ebastine D6 & Carebastine D6) as internal standards. Different parameters such as linearity, range, precision, accuracy, ruggedness and robustness, limit of detection (LOD) and limit of quantification (LOQ) were used for full validation of the method. The results were found to be acceptable as per the guidelines of International Conference on Harmonization (ICH). The method found to be novel, rapid, linear, precise, accurate, robust and rugged and can be successfully applied for the routine analysis of Ebastine and Carebastine with more sensitivity and covers wider range of quantitation. The method also found to be useful and economical.
SYNTHESIS, SPECTRAL AND MOLECULAR CHARACTERIZATION OF SOME NOVEL 2, 5-DISUBSTITUTED-1, 3, 4–OXADIAZOLE DERIVATIVES AND EVALUATION OF IN VIVO ANTITUMOUR ACTIVITY AGAINST HT 29 CELL LINE
Authors: Bhaumik Asish , Eswaraiah M. Chinna , Chakraborty Raja
Published: November 2018

Neoplasia is a type of abnormal and excessive growth of tissue. The growth of a neoplasia is uncoordinated with that of the normal surrounding tissue, and it persists growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass. The main objective of the present research work was the synthesis, characterization and evaluation of in vivo antitumour activity of some novel 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives. The in vivo antitumour activity of synthesized compounds was evaluated by HT 29 cell line induced malignant ascites on mouse model. The apoptosis of HT 29 cells was evaluated by using Gimsa and H33342 stain and the apoptosis ratios were analysed by FCM using AnnexinV-FITC/PI staining. The present experimental data displayed that the mortality was less in all groups except in tumour control group and all the synthesized compounds AB1-AB8 (100 mg/kg) significantly increased the PILS. While 5-FU increased the life span of 97.72%, and the PILS of synthesized compounds were found to be 45.45%, 59.09%, 68.18%, 56.81%, 38.63%, 84.09%, 77.27% and 90.90%. So the Synthesized compounds AB1-AB8 at the dose of 100 mg/kg significantly improved the overall survival of all treated animals and 5-FU was not significantly differed from each other in improving the overall survival of HT-29 cells. The apoptosis ratios of synthesized compounds were found as followed: AB1=26%; AB2=37.6%; AB3=43%; AB4=29%; AB5=24.1%; AB6=59.2%; AB7=48.2%; and AB8=63% respectively, while that of the Group-II (T. control) was 6.1%. When compared with standard drug 5-FU: 66.2%, it was indicated that compound AB8>AB6>AB7>AB3 were able to significantly induce HT-29 cells apoptosis.
FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF ELETRIPTAN FAST DISSOLVING ORAL FILMS
Authors: Somwanshi Shrushti V. , Thonte Sanjay S.
Published: November 2018

The present study aimed at preparing fast dissolving oral films of Eletriptan as a model drug which is used for the migraine treatment. Fast dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties. In the present research work various trials were carried out using different grades of HPMC E3, E6, and E15, maltodextrin DE6 and other polymers by solvent casting method.  The prepared films were evaluated for film thickness, folding endurance, surface pH, morphological properties, % drug content and content uniformity, tensile strength, percent elongation, in vitro disintegration time and in vitro dissolution studies. The optimized formulation F24 prepared using HPMC E15 showed minimum disintegration time (10 sec), highest dissolution rate i.e. 99% of drug within 8 min and satisfactory physicochemical properties. The optimized film was evaluated for its bioavailability compared with pure drug as reference standard. Statistical analysis revealed that no significant difference between the bioavailability parameters of the film and the reference standard indicated that they exhibited comparable plasma level-time profiles. These findings suggest that the fast dissolving film containing Eletriptan is considered to be potentially useful for the treatment of migraine where quick onset of action is desirable.