bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Pemanfaatan Tumbuhan Obat yang Berpotensi sebagai Obat Covid-19 kepada Guru-guru IPA se Kabupaten Kaur
Authors: Sundaryono Agus , Karyadi Bhakti , Ruyani Aceng , Nursaa'adah Euis , Listiono Arsela Eko
Published: December 2023

Kebiul merupakan tumbuhan obat Masyarakat suku Serawai Bengkulu. Oleh masyarakat biji Kebiul digunakan  sebagai obat malaria. Biji Kebiul telah diteliti mampu menghambat perkembangan Plasmodium berghei pada Mencit. Tujuan kegiatan ini adalah sosialisasi hasil penelitian melalui Pelatihan Pemanfaatan Tumbuhan Sumber Daya Lokal sebagai Obat Malaria yang Berpotensi sebagai Obat Covid-19 pada Guru  IPA  di Kabupaten Kaur. Pada awal kasus pandemic covid 19  beberapa peneliti melaporkan bahwa klorokuin dapat digunakan sebagai obat Covid-19, Berdasarkan uji praklinik biji Kebiul, mampu menghambat  perkembangan plasmodium malaria secara lebih baik dibandingkan dengan klorokuin. Melalui gambaran penelitian ini dimungkinkan biji Kebiul mempunyai potensi digunakan sebagai obat Covid-19. Pelatihan ini juga dimaksudkan sebagai upaya membangun sikap konservasi (pemanfaatan sumberdaya alam secara bijaksana) tentang tumbuhan obat di lingkungan sekolah. Pelatihan  diikuti oleh 40 guru IPA, hasil pelatihan berjalan baik, peserta mengikuti kegiatan secara aktif, hasil evaluasi pemahaman materi juga baik, dengan kriteria nilai sangat bagus.
Pemberdayaan Karang Taruna Desa Kemumu Sadar Potensi Wisata Melalui Aplikasi Filmora Sebagai Sarana Video Marketing Destination Publication Sport Tourism
Authors: Ilahi Bogy Restu , Septian Raibowo  , Fina Hiasa
Published: December 2023

Kegiatan ini berjudul Pemberdayaan Karang Taruna Desa Kemumu Bengkulu Utara Sadar Potensi Wisata Melalui Penerapan IPTEKS Aplikasi Filmora Sebagai Sarana Video Marketing  Destination Publication Sport Tourism Tujuan pengabdian ini untuk untuk menambah pengetahuan Karang Taruna Desa Kemumu Bengkulu Utara tentang Aplikasi Filmora Sebagai Sarana Video Marketing  Destination Publication Sport Tourism. Metode yang kami gunakan dalam kegiatan pengabdian masyarakat ini adalah metode pelatihan dengan cara ceramah dan tanya jawab serta mengadakan praktek langsung bagi para peserta pelatihan. Kegiatan Pelatihan Penggunaan Aplikasi Filmora Untuk Meningkatkan Aplikasi Filmora Sebagai Sarana Video Marketing  Destination Publication Sport Tourism. dan  dilaksanakan 2 hari  pada hari Sabtu, 20 Agustus 2022. Kegiatan ini dimulai pada pukul 13.00 WIB sampai dengan pukul 16.00 WIB. Dan minggu pada pukul 08.00 sampai dengan  pukul 11.00 WIB Peserta kegiatan ini adalah Karang Taruna Desa Kemumu Bengkulu Utara berjumlah 20 orang Pelatihan ini menghasilkan peningkatan pengetahuan pemuda Karang Taruna Desa Kemumu Bengkulu Utara tentang penggunaan Aplikasi Filmora Sebagai Sarana Video Marketing  Destination Publication Sport Tourism yaitu sebagai berikut: pengetahuan awal sebelum pelatihan Penggunaan Aplikasi filmora Untuk Meningkatkan Keterampilan pembuatan video marketing sebesar 43%, pengetahuan setelah Penggunaan Aplikasi filmora Untuk Meningkatkan Keterampilan Menulis Dan Publikasi Pada Guru-Guru sebesar 86.50%.
Penyuluhan Kesehatan Gigi dan Mulut Pada Kader di Kelurahan Kampung Baru Padang
Authors: Aisyiah Intan Kamala , Nurmaines Adhyka  , Tosi Rahmaddian
Published: December 2023

Kesehatan gigi dan mulut merupakan hal yang penting dalam kehidupan setiap individu. Data Riset Kesehatan Dasar tahun 2018, proporsi perilaku menyikat gigi setiap hari penduduk umur tiga tahun ke atas adalah 94.7%, namun proporsi yang menyikat gigi dengan benar hanya 2.8%. Hal ini menjadi masalah karena salah satu cara pencegahan yang efektif terhadap terjadinya penyakit gigi dan mulut adalah melalui tindakan menyikat gigi.   Kegiatan Pengabdian Kepada Masyarakat ini ditujukan kepada kader dan warga di Kelurahan Kampung Baru dengan target peserta berjumlah 22 orang kader/warga, 5 orang dosen dan seluruh anggota BEM FKM UNBRAH/ mahasiswa. Kegiatan berlangsung pada tanggal 25 November 2021. Dalam sosialisasi ini dilakukan penyebaran kuesioner dalam peningkatan pengetahuan kader dan warga. Kegiatan dilakukan dengan metode pemaparan materi, diskusi dan simulasi. Disarankan untuk pelatihan ini dilakukan dengan dihadiri oleh masyarakat/ warga sekitar, mulai dari anak-anak hingga orang dewasa. Usia mulai dari 9 tahun adalah usia efektif untuk memberikan segala informasi yang mengarah pada perkembangan kognitif dan motorik anak, termasuk cara menyikat gigi yang baik dan benar
Pelatihan Pembuatan Program Outdoor Education untuk Guru-Guru Pendidikan Jasmani
Authors: Hernawan Hernawan , Wasan Aan , Widyaningsih Heni
Published: December 2023

Pengabdian Masyarakat Kepada guru pendidikan jasmani ini bertujuan untuk melatih guru-guru pendidikan jasmani Kecamatan Conggeang Provinsi Jawa Barat membuat Program outdoor education.  Tempat penelitian dilaksanakan di Kecamatan Conggeang  Provinsi Jawa Barat.  Waktu pelaksanaan kegiatan dimulai Bulan April sampai dengan Oktober 2022. Metode yang digunakan dalam menjalankan program pengabdian masyarakat kepada guru pendidikan jasmani ini adalah: diskusi informasi, demonstrasi, pembimbingan, latihan, dan praktek langsung. Berdasarkan pengamatan dan pelaksanaan Pelatihan Pembuatan Program outdoor education untuk Guru-Guru Pendidikan Jasmani di Desa Conggeang Kulon dan Desa Conggeang Wetan Kecamatan Conggeang Kabupaten Sumedang Provinsi Jawa Barat ini serta diskusi dengan para guru-guru pendidikan jasmani tersebut, mereka merasa sangat antusias dalam  mengikuti kegiatan ini serta mendapatkan informasi dan manfaat yang sangat banyak terutama dalam hal pemahaman program outdoor education. guru- guru merasa bertambahnya pengetahuan dan keterampilan dalam hal pemahaman Pembuatan program outdoor Education. Pihak pengurus KKGO dan MGMP Pendidikan Jasmani Kecamatan Conggeang Kabupaten Sumedang mengharapkan adanya kegiatan secara periodik mengenai pembinaan untuk Guru-guru pendidikan jasmani.
The Impact of Technology Media Applications on Aspects of Student Responsibility on Physical Education Learning
Authors: Dhani Agusni Zakaria  , Sumbara Hambali  , Silvy Juditya  , Henry Asmara  , Sutiswo
Published: December 2023

This study aims to find out how much impact the use of technology media in the period of limited face-to-face learning has on aspects of student responsibility in Physical Education learning. The method used is to use an ex-post facto quantitative  approach. The population in this study was all students at SMKN 10 Bandung,  with the samples in this study being class XII Karawitan 1, 2, and 3 students. The sampling technique used  the sampling quota technique, and  the number of samples in  this study was  70 people.  The research instrument used is with a questionnaire. The data analysis technique uses percentage analysis calculations with the help of the SPSS for windows version 22 and Microsoft Excel programs. The results of this study show that the impact of the use of  PJOK learning technology media  during the face-to-face learning period is limited to the aspect of student responsibility that is in the "moderate" category with a perception rate of 78.6%. It is hoped that  schools must still develop, pay attention to, and maintain the  use of school application media, and a teacher must be able to package the PJOK learning  process so that obstacles in PJOK learning can be minimized properly, and  students must remain enthusiastic  and enthusiastic in physical education learning  with various methods given by the teacher.
Web Based Petanque Sports Match Statistics
Authors: Aidilla Pratiwi Siregar  , Ibrahim Sembiring  , Albadi Sinulingga
Published: December 2023

This research aims to (1) Produce a product on web based Petanque sport match statistics , (2) Find out the use of Petanque sport match statistics. This research uses the Research and Development Method ( R & D) refers to the development model from Borg and Gall through 8 stages , namely: (1 ) Potential and problems, (2) Information collection, (3) Product design, (4) Design validation, (5) Design revision, ( 6) Small scale trial, (7) Revision of small scale trial, (8) Large scale trial, (9) Final product. The subjects of this research during small group trials during routine training were 7 athletes and 4 coaches. During the trials, the large group consisted of 10 athletes and 8 coaches during the Sumut-Aceh PON XXI PELATDA Selection. The results of this research are (1) A web based statistical product for Petanque sports competitions to find out to what extent the athlete's abilities are during training. (2) The level of suitability of this product is determined through expert validation assessment. (3) Development and development of match statistics. The web based petanque match statistics application meets the criteria or is very feasible to use. It is proven that the development of web based Petanque match statistics is feasible to use.
Coaching and Development of Pencak Silat Sports Based on Living Respect Values in Positive Youth Development
Authors: Jeki Purnama Putra  , Nurlan Kusmaidi  , Mulyana  , Amung Ma’mun
Published: December 2023

This study aims to examine whether the integration of the concept of "living respect" in a pencak silat training program can enhance the development and understanding of living respect values within the framework of positive youth development. This study employs a group-based experimental design that includes 60 participants in a training program, with the participants being divided into two groups: a control group and an experimental group. The control group receives regular pencak silat training, while the experimental group undergoes pencak silat training that incorporates sub-dimensions of living respect, such as attitudes of tolerance, embracing differences, promoting equality, and opposing discrimination. The research results indicate that the experimental group experiences a significant improvement in the development of living respect skills compared to the control group. The integration of living respect values into the pencak silat training appears to offer effective benefits to the participants, particularly in terms of enhancing social and emotional skills that are vital in daily life. Therefore, the integration of living respect within sports and educational training can serve as an effective alternative for enhancing holistic living respect values.
The Effectiveness of Student Gymnastics in 2022 on Improving Physical Fitness
Authors: Sukmawati Noviria , Selvi Melianty  , Selvi Atesya Kesumawati  , Fanni Nur Rahma
Published: December 2023

Physical fitness can be obtained through proper, systematic, and not excessive physical exercise. One of the sports activities in supporting physical fitness is the SKJ Student 2022 exercise. Physical fitness can be obtained through proper, systematic, and not excessive physical exercise. One of the sports activities in supporting physical fitness is the SKJ Student 2022 exercise. The purpose of this study was to determine Effectiveness of Student Gymnastics in 2022 on Improving Physical Fitness. This type of research uses experimental research. The population in this study were all students of the Sports Education Study Program at Bina Darma University Palembang, totaling 44 people. The instruments in this study were the Indonesian Physical Fitness Test (TKJI), namely; 1) 60 meter sprint, 2) 60 second elbow hanging test, 3) 60 second lying seat, 4) upright jump, and 5) 1000 meter run. The results showed that the 2022 student physical fitness exercise was effective in improving the physical fitness of students of the Bina Darma University Sports Education Study Program Palembang, with an average value before (pre-test) physical fitness exercise training was 12.89, while the average value after (post-test) student physical fitness exercise training 2022 was 16.02.
A Colorful Question Game to Improve Children Motor Skills in 4th Class Elementary School
Authors: Kesumawati Selvi Atesya , Aprizal Fikri  , Noviria Sukmawati  , Husni Fahritsani
Published: December 2023

This research aims to develop a basic motor skills learning model through game activities tailored to the developmental stages of students' ages. The game model used in this research is called "Colorful Question." This game is designed to enhance locomotor skills, particularly the basic movements of jumping and hopping, which are highly beneficial for training leg muscle strength, coordination, attention focus, and cognitive abilities of students. The research follows the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). The subjects of this study are fourth-grade students in both boys' and girls' elementary schools, consisting of 27 participants in a small-scale pilot test and 65 participants in a large-scale pilot test. Validation results from experts show a CVI (Content Validation Index) value of 3.57 and a CVR (Content Validity Ratio) of 0.01, indicating that the developed "Colorful Question" game has high validity and is suitable for fourth-grade elementary school students, making it suitable for field testing (empirical validation).
Analysis of Limb Explosive Performance of Elite Water Ski and Wakeboard Athletes: A Comparative Study
Authors: Maslikah Uzizatun , Fachrezzy Fahmy , Mansur Jauhari  , Arga Nurcahya  , Nugroho Haris
Published: December 2023

This research uses the Survey Research Method, a quantitative research type approach meaning research that is comparative or different. The population and sample in this study were water skiers and wakeboard athletes as many as 30 people consisting of male and female athletes. Data collection techniques using tests and measurements: physical condition tests; For leg muscle explosiveness by using a vertical jump measuring instrument and a chronojump. Data analysis using quantitative descriptive analysis techniques, overall The data analysis technique used is a t-test at a significant level of 5%. To obtain the results of this study, which one better results from the explosive power of leg muscles in Water Ski and Wakeboard Athletes of DKI Jakarta Province using Vertical jump and Chronojump? The results of this study showed that: There was a difference in leg explosive power in terms of the use of vertical jump and chronojump tools in  Water Ski and Wakeboard athletes with an average value between the two groups, wherein the vertical jump group with an initial test average value of 47.50,  the chronojump group with an average value of 27.97. This means that the vertical jump group is better than the chronojump group. However, further research is needed related to the environmental, psychosocial, and psychological factors of athletes and those related to improving athlete performance.
Vasyl Sukhomlynskyi in Dialogue with Modernity. Sides of a Teacher’s Personality in Today’s Dimensions (to the 105th anniversary of the birth of Vasyl Sukhomlynskyi and the 30th anniversary of the holding of all-Ukrainian pedagogical readings)
Authors:   V. O. Sukhomlynskyi State Scientific and Educational Library of Ukraine
Published: December 2023

The collection contains abstracts of speeches of participants of the XIII International and XXX All-Ukrainian Pedagogical Readings – Vasyl Sukhomlynskyi in Dialogue with Modernity. Sides of a Teacher’s Personality in Today’s Dimensions (to the 105th anniversary of the birth of Vasyl Sukhomlynskyi and the 30th anniversary of the holding of all-Ukrainian pedagogical readings), which took place at V. O. Sukhomlynskyi State Scientific and Pedagogical Library of Ukraine on September 20, 2023.
Modulating Effect of Extremely High-Frequency Low-Intensity Electromagnetic Radiation on Tissue Oxidative Metabolism and Skin Microhemodynamics
Authors: Ravaeva M. Yu. , Cheretaev I. V. , Chuyan E. N. , Galenko-Yaroshevskii P. A.
Published: December 2023

We set out to examine the indicators of microhemodynamics and tissue oxidative metabolism in rats after their tenfold exposure to extremely high-frequency low-intensity electromagnetic radiation (EHF EMR). The aim was to elucidate the specifics of skin microcirculation and tissue oxidative metabolism following exposure to tenfold electromagnetic radiation of extremely high frequency. The experiment was carried out on 40 mature male Wistar rats weighing 200–220 g, which were kept in standard vivarium conditions under natural light regimen. The animals were divided into two groups with 20 rats each. The animals in the first group were biological controls and were exposed to false EHF EMR (placebo); the animals in the second group were exposed to mm-exposure in the morning, 10 sessions daily. On the 10th day of EMR exposure, the indicators of skin tissue fluorescence on the tail base were recorded. Tenfold exposure to low-intensity EHF EMR was shown to increase the concentration and intensity of NADH fluorescence, as well as the FAD and redox ratio. This indicates an increased cellular demand for ATP and the predominance of oxidative phosphorylation over other processes, thus demonstrating the activation of the respiratory chain. At the same time, an increase in endothelium-dependent vasodilation, a decrease in peripheral resistance, an increase in blood flow to the nutritive microvascular bed, and an improvement in venular outflow were observed in the microcirculatory bed. The conclusion is made that the modulating effect of EHF EMR is manifested in the rearrangements of correlations. Thus, the coefficient of variation comes to the fore – the final calculated indicator of microcirculation, which has strong negative associations with all indicators of tissue metabolism (FAD, NADH, RR). In addition, the amplitudes of endothelial rhythms associated with periodic releasing of nitric oxide by the endothelium show a strong negative association with FAD.
Use of Low-Frequency Pulsed Magnetic Field to Modify the Stress-Induced Animal Health Caused by Epinephrine Hydrochloride
Authors: Ananieva Yu. E. , Zakharova O. A. , Fedotov V. D. , Labyntseva O. M.
Published: December 2023

In this work, we investigate the preconditioning action of various modes of pulsed magnetic field (PMF) on the blood biochemical parameters of rats exposed to adrenal toxemia. PMF was shown to trigger adaptive response; however, its rate can differ depending on the selected PMF mode. The possibility of using low-frequency PMF as a protector of stress-induced conditions caused by adrenal toxemia is demonstrated.
Comparative Immunogenicity of the Gam-COVID-Vac Vaccine under Intranasal and Intramuscular Administration
Authors: Katorkina E. I. , Lyagoskin I. V. , Bocharova E. N. , Bolotnikova M. V. , Borzov A. A. , Belskaya N. V. , Lisova A. E. , Ulyanova K. V. , Kudina N. K. , Belyanina N. A. , Strizhakova O. M. , Pershin A. S. , Bahareva Ya. A. , Kargopolova P. E. , Vasiliev A. P. , Kazarov A. A. , Lykov M. V. , Khamitov R. A.
Published: December 2023

In this work, we set out to compare the immunogenicity of the Gam-COVID-Vac two-component vaccine produced by GENERIUM JSC (Russia) following its intranasal or intramuscular administration of the first or both components to BALB/c mice. The immunogenicity was evaluated according to antigen-specific IgG and IgA antibodies in the blood and bronchoalveolar fluid, the number of antigen-specific IFN-γ-producing T-lymphocytes, the number of antigen-specific IFN-γ-producing CD4 and CD8 T-lymphocytes. Intranasal administration was shown to induce the mucosal immunity, significantly exceeding both qualitatively and quantitatively the effect of intramuscular administration (by the number of animals with antigen-specific IgA antibodies and the titer of antibodies in blood serum and bronchoalveolar lavage). At the same time, intramuscular administration slightly exceeded the effect obtained under intranasal administration in terms of the total number of CD8-IFN-γ-producing lymphocytes.
Results of Phase III Clinical Trial: a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Direkord in Ischemic Stroke Patients in Early Recovery Period
Authors: Pomytkin I. A. , Pisarev V. V. , Merkulov M. E. , Lukinykh L. V. , Morzhukhina M. V. , Karkischenko N. N.
Published: December 2023

Direkord is an original drug containing the active substance of dicholine succinate, which improves the sensitivity of insulin receptors in neurons to insulin. The aim of this work was to evaluate the efficacy and safety of the drug in ischemic stroke patients in the early recovery period. In total, 160 patients after the first ischemic stroke in the carotid system, confirmed by computed or magnetic resonance imaging, with a stroke duration from 3 weeks to 2 months, mean age 63.2±8.4 years, were randomized into two treatment groups. The first group (n=80) received Direkord intramuscularly at a dose of 600 mg/day for two weeks; the second group (n=80) received a placebo. Treatment response was defined as an improvement in neurological status, functional status, and cognitive function of the patients: at least a two-fold decrease in the total NIHSS score, the total Barthel score ≥ 95, and the total MoCA score ≥ 26. The analysis of the primary endpoint of the study using exact Fisher’s test showed that Direkord was statistically significantly superior to the placebo (p=0.017) in the number of patients who responded to the therapy — 23.7 and 8.7% of patients in groups, respectively. The secondary end point analysis revealed a statistically significant superiority of Direkord over the placebo in reducing neurological deficits on the NIHSS scale (p=0.004), on the Rankin scale (p=0.0357), and on the CGI-I (p<0.001) and PGI-I (p<0.001) global clinical impression scales. Direkord has a good safety profile; thus, no statistically significant differences were found with the placebo in any of the safety parameters, including the number of adverse events, vital signs, laboratory parameters, and ECG. Overall, Direkord is statistically significantly more effective than placebo in recovering function and daily activities after ischemic stroke.
Penyuluhan dan Demonstrasi Cuci Tangan Pakai Sabun (CTPS) dan Sikat Gigi di SD Kampung Simporo Kabupaten Jayapura
Authors: Irjayanti Apriyana , Tambing Yane , Bela Sarni Rante Allo , Irmanto Maxsi , Rumaropen Nofa Falentina
Published: December 2023

Clean and Healthy Living Behavior at school is a behavior that is practiced by students, teachers, and the whole community in the school environment, based on awareness that allows individuals to independently improve health, prevent disease and play an active role in creating a healthy environment. This counseling and demonstration service activity aims to increase students' knowledge about the importance of clean and healthy living behavior in the school environment in order to create a healthy school. The community service was carried out on Friday, 19 August 2022 at Kampung Simporo Elementary School, Jayapura with a total of 39 elementary school students, using counseling methods and demonstrating how to wash hands with soap and brush their teeth accompanied by a discussion and question and answer session after finished presenting short material and playing an animated video. The form of evaluating the success of this activity is by direct observation of students in practicing how to wash their hands with soap and brush their teeth whether they are in accordance with the steps conveyed during counseling. The results show that all students are able to apply the material that has been delivered, seen during the demonstration activities they can practice it well at each stage. It is hoped that with this activity students, teachers, and the community around the school will be able to improve health and prevent disease and play an active role in creating a healthy environment.
Sosialisasi dan Skrining Sindrom Metabolik melalui Pengukuran IMT, Tekanan Darah, serta Pemeriksaan Glukosa Darah pada Orang Dewasa di Masa Pandemi Covid-19
Authors: Wikandari Ririh Jatmi , Purlinda Devi Etivia
Published: December 2023

Metabolic syndrome is caused by a poor lifestyle, excessive food consumption, lack of physical activity. Someone with metabolic syndrome will be more susceptible to Covid-19. This community service activity aims to provide knowledge about metabolic syndrome as well as measurement of Body Mass Index (BMI), measurement of blood pressure and checking blood glucose levels. The method of carrying out activities is in the form of outreach related to metabolic syndrome and screening for metabolic syndrome through BMI measurements, measuring blood pressure using a digital tensimeter and checking blood glucose levels using the Point of Care method. The activity was carried out in Bangetayu Kulon RT 07 RW 01 Semarang City on May 13-15 2022. The target audience is adults aged 20-65 years with a total of 56 people. From the results of the examination, it was found that 87.5% of respondents had hypertension, 12.5% of respondents had diabetes mellitus and 73.2% of respondents were obese. Community service activities provide an overview of public health about metabolic disorders so that it is hoped that after this activity the community routinely conducts health checks to prevent metabolic syndrome.
Pendampingan Pemilihan Jajanan Sehat sebagai Upaya Pencegahan Obesitas pada Anak Usia Sekolah
Authors: Yulistianingsih Ari , Firdaus Asep Novi Taufiq
Published: December 2023

High-calorie snacks triggers the accumulation of fat in the body which can cause overweight and obesity in children. In addition, high-calorie snacks intake affects academic performance. Based on preliminary study, 57% of primary school students consume high-calorie snacks. In addition, the lack of healthy canteen facilities triggers children to buy food outside of school. Based on initial observations, 80% of food vendors sell high calorie and simple sugars snacks. This community service aims to assess the effectiveness of assistance to school children's knowledge as an effort to prevent obesity. This study used the PAR (Participatory Action Research) approach through the lecture method using animated videos, peer groups and demonstrations. Results shown that nutrition mentoring program can increase nutrition knowledge in primary school-aged children by 55%. It was concluded that mentoring the selection of healthy snacks for school children can increase knowledge in preventing obesity.
Upaya Peningkatan Imunitas Anak Karyawan Universitas Muhammadiyah Palembang dengan Vaksinasi Influenza
Authors: Chairani Liza , Purwoko Mitayani , Wakilla Putri
Published: December 2023

Influenza is a highly contagious respiratory tract disease, caused by several influenza RNA viruses. The Influenza vaccine shows a protective effect against the virus that causes COVID-19. The purpose of this activity was to increase parents' knowledge about influenza and increase children's immunity to the influenza virus. The form of activity was divided into two, namely health counseling to the parents and then followed by injecting the Influenza vaccine to the children. The health education method chosen was counseling in big class at Family Medicine Clinic, Faculty of Medicine, Universitas Muhammadiyah Palembang. Health education was preceded by a pre-test with 5 multiple choice questions and ended with a same-question post-test. The average pre-test score was 75.5 and the post-test score was 93.3. There was an increase in the score which indicates an increase in the knowledge of the parents. Of the 18 parents who attended counseling, only 6 parents allowed their children to be vaccinated. The number of children vaccinated was 11 people. The follow up showed no sign of adverse effects of Influenza vaccination on children.
Pemenuhan Gizi Ibu Hamil KEK melalui Program Pendampingan Ibu Hamil di Kelurahan Graha Indah Balikpapan
Authors: Rahmawati Eli , Hariyani Faridah , Noviasari Damai
Published: December 2023

Nutritional problem due to prolonged lack of food intake is a Chronic Energy Deficiency (CED). There is a risk of impairing fetal growth and development which results in stunting, prematurity, birth defects, LBW, and fetal/baby death. Efforts to improve the nutritional status of pregnant women with CED include nutrition education through assistance by cadres/ health workers. The purpose of this community service is to assist in fulfilling the nutrition of pregnant women with SEZ through home visits. Assistance methods include nutrition education, PMT, giving blood supplement tablets and multivitamins, and ANC checks. Assistance was carried out 2 times: first pretest nutrition education, PMT, blood tablets, and multivitamins, second 2 weeks from the first visit to monitor pregnancy conditions, and post-test. The number of participants was 20 people. The results of the activity increased knowledge from the average pre-test score of 7 to 11, on the attitude of the average score of 12 to 16, and behavior from the average score of 9 to 13. The results of statistical tests using the Wilcoxon Test obtained a value of p = 0.000. This explains that there is a significant increase in knowledge, attitude, and behavior before and after the assistance of pregnant women. It is hoped that assistance in fulfilling the nutrition of pregnant women with CED can improve the fulfillment of nutrition for pregnant women with CED, reduce the risks that occur to mothers and babies, and can be used as one of the programs in preventing stunting.
Penciptaan Wirausaha Baru di Kampus Poltekkes Kemenkes Palu melalui Pengembangan Produk-Produk Bakery dan Kudapan
Authors: Nurjaya Nurjaya , Aminuddin Aminuddin , Bahja Bahja
Published: December 2023

The liver and entrails of cakalang fish can be mixed into bakery products and other snacks using the latest technology to eliminate the fishy flavours. Although this product is believed to have selling value, this product has never been used as an idea in entrepreneurship. the target group is students and graduates who are or have been in the product sales business and have experience in the field of product marketing, a total of 10 people. The method of implementing the coaching system is related to practical knowledge about entrepreneurship and product manufacturing through training activities and technical guidance. Monitoring and evaluation of program success is carried out after 3 (three) months of entrepreneurial development with the achievement targets being the number of promotional activities and net profit earned. The results obtained were that there were 4 (four) people or 40% of participants who developed products in their line of business, where 2 people carried out business/entrepreneurship development and 2 people developed products into a snack menu at work. The average percentage of sales profit achievement is around 50% calculated during product sales. Based on the results of the program, it can be concluded that superior products have been created that can be developed into business ventures for students and graduates as training participants.
PERANCANGAN SISTEM INFORMASI LABORATORIUM TEKNIK INDUSTRI UNIVERSITAS NEGERI GORONTALO
Authors: Lasalewo Trifandi , Budjang Dhimiral Alfasih , Arafat Muh. Yasser
Published: December 2023

Website adalah kumpulan halaman dalam suatu domain yang memuat tentang berbagai informasi agar dapat dibaca dan dilihat oleh pengguna internet melalui sebuah mesin pencari. Penelitian ini bertujuan untuk menghasilkan sistem informasi yang digunakan sebagai sarana pengelolaan manajemen Laboratorium Teknik Industri UNG. Metode penelitian yang digunakan adalah metode prototype. Penelitian ini menghasilkan sebuah sistem informasi Laboratorium Teknik Industri UNG berbasis web yang mempermudah penyimpanan data maupun pengarsipan laboratorium dan mempermudah civitas akademika maupun masyarakat dalam mendapatkan informasi serta kebutuhan pelayanan dari laboratorium Teknik Industri UNG.
Sociodemographic factors associated with major depressive episodes and suicidal ideation among emerging adults with diabetes in the U.S
Authors: Yadav Sandhya , Hong Young-Rock , Westen Sarah , Marlow Nicole M. , Haller Michael J. , Walker Ashby F.
Published: December 2023

Background

Research focused on disparities related to mental health comorbidities, especially among emerging adults with diabetes, is limited. Identifying associated factors of disparities could inform policy decisions to make diabetes-related interdisciplinary care more accessible for vulnerable groups.

Method

Using data from the National Survey on Drug Use and Health (2015-2019), we examined disparities in presence of major depressive episode (MDE) and suicidal ideation among emerging adults with diabetes. Survey design-adjusted bivariate and multivariable logistic regression models were used for statistical analyses.

Results

The study included 1,125 emerging adults (18-25 years old), with a history of type 1 diabetes (T1D) or type 2 diabetes (T2D). After controlling for sociodemographic and health-related characteristics, we found lower odds of having past-year major MDE for non-Hispanic Black (AOR, 0.42, p=0.032) compared to their non-Hispanic White counterparts. Females were 3.02 times more likely to have past-year MDE than males (AOR, 3.02, p=0.004). The odds of having past-year MDE were 1.96 times higher among individuals who identified as LGB (lesbian, gay, bisexual) (AOR, 1.96, P=0.038). There were no statistically significant disparities in suicidal ideation related to race/ethnicity, sex, education, and family income. However, individuals who identified as LGB had significantly higher likelihood of suicidal ideation than their heterosexual counterparts (AOR, 2.47, P=0.004).

Conclusion

Significant disparities related to MDE and suicidal ideation exist based on race/ethnicity, gender, and sexual orientation. Integration of a mental health professional into the multidisciplinary diabetes care team is critical for effective management of comorbid mental health conditions in younger patients with diabetes.
Does denosumab exert a protective effect against COVID-19? Results of a large cohort study
Authors: Cassibba Sara , Ippolito Silvia , Pellegrini Silvia , Trevisan Roberto , Rossini Alessandro
Published: December 2023

Introduction

Denosumab is a monoclonal antibody blocking the receptor activator of nuclear factor kappa-B/receptor activator of nuclear factor kappa-B ligand (RANK/RANKL) pathway, thus inhibiting osteoclastogenesis. Since RANK and RANKL are also involved in the immune system activation, denosumab might interfere with the response against infections. Our study aimed to explore the relationship between denosumab treatment and coronavirus disease 2019 (COVID-19).

Design and methods

The occurrence and severity of COVID-19 were recorded in consecutive patients referred to the Endocrinology Department of Papa Giovanni XXIII Hospital, Bergamo, from 1 January 2020 to 1 January 2021. Patients treated with denosumab were compared to outpatient controls. Patients’ features were summarized by descriptive statistics. Multivariate logistic regression assessed the relationship between denosumab and COVID-19, adjusting for potential confounders. Subgroup analyses according to age, sex, body mass index (BMI), smoking status, and vitamin D levels were performed.

Results

The final population included 331 patients treated with denosumab and 357 controls. COVID-19 incidence was lower in the denosumab group (7.6% vs. 14.6%, p = 0.004). COVID-19 severity was similar in both groups. Multiple logistic regression confirmed an association between denosumab and a reduced occurrence of symptomatic COVID-19 [odds ratio (OR) 0.46, 95% CI 0.21–0.98, p = 0.049]. Subgroup analyses suggested a potential protective effect of denosumab in patients over 75 years (OR 0.12, 95% CI 0.02–0.6, p = 0.011), with a significant interaction between denosumab and age categories (p = 0.047).

Conclusion

Our study confirms that denosumab may be safely continued in COVID-19 patients. RANK/RANKL inhibition seems associated with a reduced incidence of symptomatic COVID-19, particularly among the elderly.
A comparison of migrant and non-migrant households’ choices on migration and coping mechanisms in the aftermath of cyclone Aila in Bangladesh
Authors: Ahmed Khandaker Jafor , Atiqul Haq Shah Md , Hyder Md. Badrul
Published: December 2023

This research focuses on understanding the complex impact of Cyclone Aila on migration decisions, particularly regarding the motivations that compel specific vulnerable populations to remain in their current locations despite severe consequences. It conducts a comparative analysis of migration choices, adaptive strategies and capacities of migrant and non-migrant populations in Bangladesh after the 2009 Cyclone Aila, focusing on the severely affected districts of Satkhira and Khulna. To achieve this, a comprehensive survey of 284 households was conducted, including 130 migrant and 154 non-migrant households. The research utilized statistical techniques, such as frequency distribution, chi-squared tests, and multinomial logistic regression, along with qualitative insights gathered through in-depth interviews and analyzed using NVivo software to provide a more comprehensive understanding of the coping capacities of these households. The findings indicate that the severity of the cyclone experience significantly impacted migration choices, with non-migrant households displaying a firm attachment to their original location because of better economic opportunities, emotional bonds, vibrant social networks, and a higher tolerance for adversity. Migrants are attracted to locales, providing better living conditions, safety, and access to healthcare and education. This research also revealed differences in the adaptive strategies adopted by migrants and non-migrants. Migrants have more options for housing, agriculture, livestock management, food security, health and sanitation, and employment. Most migrant households (47.7%) had high adaptive capacities across various domains, such as food security, housing and shelter, crop production, livestock and poultry rearing, health and sanitation, and livelihood prospects. Non-migrant households had much lower percentages of high adaptive capacity, ranging from 5.3 percent to 9.7 percent. These findings suggest that migration can improve adaptive capacity, especially when responding to weather events, such as Cyclone Aila. Therefore, it is important to create targeted support measures that cater to the unique needs of both migrant and non-migrant households to promote resilience and improve wellbeing during the post-crisis period.
Variability of biological traits of Bulinus truncatus and Biomphalaria pfeifferi, the intermediate host snails of schistosomiasis, from three climatic zones of Côte d’Ivoire
Authors: Diakité Nana R. , Koffi Patricia B. , Konan Cyrille K. , Bassa Fidèle K. , Chamberlin Andrew J. , Ouattara Mamadou , De Leo Giulio A. , N’Goran Eliezer K.
Published: December 2023

Background: Schistosomiasis is endemic throughout all regions of Côte d’Ivoire, however, species of the intermediate snail host vary across bioclimatic zones. Hence, a deeper knowledge of the influence of climatic on the life history traits of the intermediate snail host is crucial to understand the environmental determinants of schistosomiasis in a rapidly changing climate. The aim of this study was to run a common garden experiment to assess differences in survival, somatic growth and fecundity of both Bulinus truncatus and Biomphalaria pfeifferi snails collected in three different bioclimatic areas.

Methods: A cross-sectional malacological survey was conducted in February 2021 in the south, center and north of Côte d’Ivoire. We sampled two populations of B. truncatus, the intermediate host snail of Schistosoma haematobium, from northern and central Côte d’Ivoire, and two populations of Bi. pfeifferi, the intermediate host snail for Schistosoma mansoni, from the southern and central regions. Snails collected at the human-water contact sites were brought in the laboratory where they reproduced. The first generation snails (G1) for each population were reared under the same laboratory conditions, i.e., at 24°C–26°C, during 63 days (9 weeks), to estimate survival, growth, and fecundity.

Results: We found that G1Bulinus snails from the north population showed higher survival and growth rates during our study and higher number of eggs at first reproduction, compared to the ones from the central region. For Bi. pfeifferi, no significant difference in survival rate was observed between G1 snails from the southern and central populations, whereas those from the south exhibited higher growth rates and higher number of eggs per individual at first reproduction than G1 snails from the central population.

Conclusion: Our study provides evidence for heterogeneity in snails’ life-history traits in response to temperature among the populations from the three climatic regions. Further experiments from multiple populations are needed to confirm that snails express traits under optimal conditions, can lead to expansion of their geographical range and hence an increase in the risk of schistosomiasis transmission. Transplantation experiments will be required to assess implications of the changing climate on snails persistence, distribution and abundance.
Impact of land use on macroinvertebrates from a multiscale perspective: enhancing structural equation models with inverse distance-weighted metrics
Authors: Ma Kai , Zhang Haiping , Zhang Min , Qu Xiaodong , Wu Nacheng
Published: December 2023

Effective riverine ecosystem management and restoration are predicated upon comprehending the relationship between land use patterns, the aquatic environment, and macroinvertebrates. However, the processes by which land use affects riverine ecosystems are exceedingly complex, influenced by factors across varying special scales. To explore these multi-scale relationships, we centered our study on the Taizi River Basin (TRB) in northeastern China, encompassing data on land use, macroinvertebrates, physical habitats, and water quality. We employed a synergy of correlation analysis, multiple stepwise regression, and redundant analysis techniques to discern these relationships at diverse spatial extents. This approach led to the development of 24 structural equation models (SEMs) that delineate the pathways bridging land use patterns to various biological indices. Remarkably, the interpretive capacity of SEM-Benthic Index of Biotic Integrity (SEM-BIBI), SEM-Shannon Wiener index (SEM-H’), and SEM-Average Score Per Taxon (SEM-ASPT) models was 76%, 70%, and 66% respectively. Within the TRB, the primary pathway from land use pattern to biological index consisted of: land use (predominantly rural and agricultural) feeding into physical habitat (habitat complexity, combined characteristic of speed and depth), which in turn affected benthic indicators. A secondary pathway charts a course from land use, through water quality (electrical conductivity and total dissolved solids) and culminating in benthic variations. Furthermore, our findings indicated that inverse-distance-weighted (IDW) metrics, specifically the IDW distance based on flow length to the stream outlet and the nearest stream (iFLO_m and iFLS_m, respectively) could provide more accurate interpretations of the river’s ecological health status. Given the effects of rural areas and agriculture on macroinvertebrates, we recommend establishing 100-m wide riparian buffers. The optimal buffer range should be determined by evaluating various biological needs and considerations.
6’-sialyllactose ameliorates the ototoxic effects of the aminoglycoside antibiotic neomycin in susceptible mice
Authors: Abou Assale Tawfik , Kuenzel Thomas , Schink Tamara , Shahraz Anahita , Neumann Harald , Klaus Christine
Published: December 2023

Sialic acids are terminal sugars of the cellular glycocalyx and are highly abundant in the nervous tissue. Sialylation is sensed by the innate immune system and acts as an inhibitory immune checkpoint. Aminoglycoside antibiotics such as neomycin have been shown to activate tissue macrophages and induce ototoxicity. In this study, we investigated the systemic subcutaneous application of the human milk oligosaccharide 6’-sialyllactose (6SL) as a potential therapy for neomycin-induced ototoxicity in postnatal mice. Repeated systemic treatment of mice with 6SL ameliorated neomycin-induced hearing loss and attenuated neomycin-triggered macrophage activation in the cochlear spiral ganglion. In addition, 6SL reversed the neomycin-mediated increase in gene transcription of the pro-inflammatory cytokine interleukin-1β (Il-1b) and the apoptotic/inflammatory kinase Pik3cd in the inner ear. Interestingly, neomycin application also increased the transcription of desialylating enzyme neuraminidase 3 (Neu3) in the inner ear. In vitro, we confirmed that treatment with 6SL had anti-inflammatory, anti-phagocytic, and neuroprotective effects on cultured lipopolysaccharide-challenged human THP1-macrophages. Thus, our data demonstrated that treatment with 6SL has anti-inflammatory and protective effects against neomycin-mediated macrophage activation and ototoxicity.
Groundwater nutrient loading into the northern Indian River lagoon: measurements and modeling
Authors: Al-Taliby Wissam , Mamoua Kamal , Pandit Ashok , Heck Howell , Berber Antonio
Published: December 2023

The Indian River Lagoon System (IRLS) has been impacted by the surrounding development, leading to excessive nutrient loads that have resulted in frequent and prolonged phytoplankton blooms in the northern reaches. Our study focused on estimating terrestrial groundwater discharge (TGD) and associated nutrient loads by combining field measurements and hydrogeologic modeling at four transects: Eau Gallie (EGT), River Walk (RWT), Banana River (BRT), and Mosquito Lagoon (MLT) across the IRLS. Multiple monitoring stations were installed to collect groundwater and surface water levels, salinity, and nutrient concentrations during 2014-2015. Samples were analyzed for dissolved inorganic nitrogen (DIN) and dissolved inorganic phosphorus (DIP). Numerical modeling was accomplished using SEAWAT to simulate TGD rates, whereas nutrient loads were calculated by multiplying simulated TGD by measured concentrations. TGD rates and nutrient loads were also estimated specifically for the “near-shore zone” along each transect. The effect of recharge from underlying Hawthorn Formation was also evaluated by incorporating estimated recharge rates into the models. Porewater and lagoon water samples showed that ammonium predominated over (NO2+NO3) and PO4 at all sites, resulting in DIN/DIP ratio surpassing the Redfield ratio. Low nitrite/nitrate, coupled with elevated ammonium concentrations at RWT, BRT, and MLT, may be attributed to biogeochemical transformations catalyzed by mangroves and wetlands. Simulated TGD showed mild temporal but significant spatial variation, especially between EGT and RWT compared to BRT and MLT. The highest average TGD of 0.73 and 0.77 m3/d.m occurred at RWT and EGT, respectively, whereas the lowest rates were predicted at BRT and MLT. The highest estimated average DIN loads of 507 and 428 g/yr.m were received at EGT and RWT, respectively, whereas MLT and BRT exhibited lower loads. The DIP loads were remarkably lower than the DIN loads and were significantly different in space and time between sites. Elevated DIN combined with reduced DIP resulted in DIN/DIP exceeding the Redfield ratio, thereby encouraging the blooming of harmful algae. Although the majority of seepage occurs through the near-shore zone, small amounts are received along the entire transect at all sites. The Hawthorn Formation does not contribute significant recharge to the aquifer at the transect locations.