bluuebunny/crossref_metadata_2025 huggingface dataset:
Approximation Algorithms for the Maximum-Weight Cycle/Path Packing Problems
Authors: Li Shiming , Yu Wei
Published: January 2023

Given an undirected complete graph [Formula: see text] on [Formula: see text] vertices with a non-negative weight function on [Formula: see text], the maximum-weight [Formula: see text]-cycle ([Formula: see text]-path) packing problem aims to compute a set of [Formula: see text] vertex-disjoint cycles (paths) in [Formula: see text] containing [Formula: see text] vertices so that the total weight of the edges in these [Formula: see text] cycles (paths) is maximized. For the maximum-weight [Formula: see text]-cycle packing problem, we develop an algorithm achieving an approximation ratio of [Formula: see text], where [Formula: see text] is the approximation ratio for the maximum traveling salesman problem. For the case [Formula: see text], we design a better [Formula: see text]-approximation algorithm. When the weights of edges obey the triangle inequality, we propose a [Formula: see text]-approximation algorithm and a [Formula: see text]-approximation algorithm for the maximum-weight [Formula: see text]-cycle packing problem with [Formula: see text] and [Formula: see text], respectively. For the maximum-weight [Formula: see text]-path packing problem with [Formula: see text] (or [Formula: see text]) with the triangle inequality, we devise an algorithm with approximation ratio [Formula: see text] and give a tight example.
Investigation of Spatial-Varying Frequencies Concerning Effects of Moving Mass on a Beam
Authors: Yang Judy P. , Su Zhi-Yuan , Yau J. D. , Yang D. S.
Published: January 2023

The spatial-varying frequency of a vehicle-bridge interaction (VBI) system subjected to a moving mass is theoretically derived and numerically investigated through a three-dimensional VBI model, in which the effects of moving mass are introduced through the inertial force and centrifugal force in the equation of motion of the bridge. For a large vehicle-to-bridge mass ratio, it has been known that the frequency of a VBI system could change with respect to the location of a moving vehicle. As such, this study derives the analytical solution based on a moving mass-beam system to account for frequency variation and further builds the numerical model with detailed implementation for practical applications. The numerical results show the following findings: (1) The frequency of a VBI system is a function of velocity and location of a moving vehicle. (2) The reduction of spatial-varying frequency ratio for a particular mode decreases with respect to the mode of higher order. (3) The maximum reduction of spatial-varying frequency ratio of the first mode in a moving mass-beam system occurs in the location where the bridge has the maximum deflection as a result of local mode excitation. (4) For the VBI system with high suspension stiffness and large vehicle-to-bridge mass ratio, the absolute variation of spatial-varying frequency ratio of the first mode can be up to 30–40%.
Method for Determining Effective Frequency Range of Coherency Based on Seismic Energy
Authors: Yu Yanyan , Ding Haiping , Zhu Yue , Luo Yi
Published: January 2023

When using data recorded by dense instrument arrays to fit the coherency model of spatial variation of seismic ground motions, the selected frequency range may affect the fitting parameters, which also affects the synthesized time history of the ground motion field. In this study, the acceleration of the 5th and the 45th Earthquake of the SMART-1 array was selected. The Abrahamson and Loh models were used to perform the parameter fitting of the coherency for frequency ranges of 0–8, 0–16 and 0–24[Formula: see text]Hz, and the obtained results were different. The smaller the frequency range, the lower the fitted lagged coherency. The influence of frequency range on fitting parameters of Loh model is much greater than that of Abrahamson model. Based on the relative relationship of ground motion energy distribution in each frequency band represented by the power spectra, from the perspective of power spectrum energy, the energy ratio concept was introduced, i.e. the ratio of the power spectra for a specific frequency range to the total power spectra. Based on the energy ratio, a method for determining the effective frequency range of the coherency model was developed. Through the comparison and analysis of the horizontal-component acceleration of the SMART-1 array, it was found that when the frequency range was 0–5[Formula: see text]Hz, the energy ratio exceeded 95%, when the frequency range was 0–8[Formula: see text]Hz, the energy in the frequency band reached approximately 99% of the total energy. Therefore, it is recommended that when the parameters of the coherency model are fitted, the frequency corresponding to an energy ratio of 95% can be used as the effective frequency. Within this range, the contamination of high-frequency components on the fitting results is minimized.
Bridging the Gap – A Traffic Light System to Ease Communication Amongst Surgeons, Hand Therapists and Patients
Authors: PAI Ashwin Alke , MAHESHWARI Kavish , HINDOCHA Sandip
Published: January 2023

Communication in the healthcare setup is essential for patient safety and for seamless delivery of services to the patient. We have adopted a novel way of communication in the form of a colour-coded visual aid in the form of a traffic light system to guide the patients through the course of their treatment. This shows the treatment plan in the form of Red, Amber, Green and Blue. The Red (Stop) denotes complete immobilisation with Splints, Amber (Proceed with caution) denotes active movements only, Green (Go forward) denotes Passive and Active movements and Blue shows when the patient can undergo guided weight bearing and strengthening exercises without a splint. The implementation of this system has created a streamlining of our protocol and improvement in the quality of the care we deliver.

Level of Evidence: Level V (Therapeutic)
Intracontinental deformation around the fixed tip of the continental-scale, strike-slip Tan–Lu fault zone in eastern China
Authors: Lu Yuanchao , Zhu Guang , Yin Hao , Wu Xiaodong , Zhang Shuai , Xie Chenglong
Published: January 2023

It remains unclear whether large-scale polyphase displacement along strike-slip faults is associated with tip propagation, and how the tip-damage zones of these faults respond to intracontinental block movements. Damage structures around the southern tip of the 2400 km long Tan–Lu fault zone (TLFZ) in eastern China provide an ideal opportunity to investigate deformation mechanisms at the tip of an intracontinental strike-slip fault. Structural and geochronological data from the southern Zhangbaling uplift within the TLFZ show that following the Triassic initiation of the fault, two phases of sinistral faulting occurred: an earlier phase at the beginning of the Early Cretaceous and later phase between the Early and Late Cretaceous. The early sinistral structures are expressed by ductile shear zones in the southern Zhangbaling uplift, whereas the younger sinistral structures are expressed as shear zones in the north and brittle faults in the south. Zircon U–Pb dating results for felsic gneiss of the TLFZ suggest that
c.
200 km of cumulative displacement occurred during the Cretaceous and was restricted to wall rocks on the western side of the fault. The southern tip of the TLFZ remained fixed during the displacement, and the dilational quadrant associated with the fault is interpreted to have been stationary. The current
c.
400 km of sinistral offset of the Dabie and Sulu orogens represents the original offset caused by the Triassic collision of the North China Craton and South China Block. The two phases of sinistral motion were induced by two phases of compression along the
c.
460 km long contractional quadrant, which was dominated by thrusting along pre-existing faults as well as fault-related folding and uplift. Damage structures at the southern tip of the TLFZ show that large-scale polyphase strike-slip motion may be associated with a fixed fault tip, hundreds of kilometres of displacement can be restricted to one side of a major fault, and displacement can be accommodated by thrusting along pre-existing faults in the contractional quadrants.

Supplementary material
: LA-ICP-MS zircon U–Pb data for the felsic gneiss sample FD30 are available at
https://doi.org/10.6084/m9.figshare.c.6368850
Vegetational change during the Middle–Late Pennsylvanian transition in western Pangaea
Authors: Schachat Sandra , Baresch Andrés , Bui Thu , Falcon-Lang Howard J. , Chaney Dan S. , Nelson W. John , Elrick Scott D. , Kerp Hans , Lucas Spencer G. , DiMichele William A.
Published: January 2023

We present the first analysis of vegetational change in far western equatorial Pangaea (New Mexico, USA) during the Middle–Late Pennsylvanian transition (determined by conodonts and fusulinids) of the Late Paleozoic Ice Age. The study is based on the largest database assembled from this region: 28 of 44 quantitatively analysed floras from 14 of 26 stratigraphic levels. Most sampled floras are ‘mixed’, both below and above the boundary, including both hygromorphic and mesomorphic/xeromorphic taxa. The taxonomic data were recalibrated morphometrically focusing on foliar traits of lamina width and venation. All data were examined using stratigraphic credible intervals, capture–mark–recapture analyses, and resampling analyses. Results indicate no substantive taxonomic turnover across the boundary. This stands in marked contrast to patterns in mid-Pangaean coal basins where there is a large wetland vegetational turnover. However, plant and physical geological data indicate that immediately following the boundary in New Mexico, and for approximately half of the Missourian Stage, floras previously dominated by hygromorphs become overwhelmingly dominated by mesomorphic/xeromorphic taxa. Although expressed differently, the western Pangaean physical and palaeobotanical patterns parallel those from mid-Pangaean coal basins and suggest a widespread environmental change.
Model-based Resource Management for Fine-grained Services
Authors: Gias Alim Ul
Published: January 2023

Brief Biography: Alim Ul Gias is currently a Research Associate at the Centre for Parallel Computing (CPC), University of Westminster. He completed his PhD from Imperial College London in 2022. Before starting his PhD, Alim was a lecturer at Institute of Information Technology (IIT), University of Dhaka (DU). He completed his bachelor's and master's program from the same institute. His current research focuses on different Quality of Service (QoS) aspects of cloud-native applications e.g., microservices. In particular, he aims to address the performance and resource management challenges concenrining the microservices architecture.
A Dual Function of Ferritin (Animal and Plant): Its Holo Form for Iron Supplementation and Apo Form for Delivery Systems
Authors: Chang Xiaoxi , Lv Chenyan , Zhao Guanghua
Published: January 2023

Ferritins represent a class of iron storage proteins with detoxification functions. The importance of these proteins is reflected by their wide distribution throughout the animal and plant kingdoms. Ferritin has two forms: holo and apo. Holo ferritin can act as an efficient and safe factor for iron supplementation, whereas apo ferritin is able to serve as a promising delivery nanovehicle for nutrients and bioactive compounds. So far, the dual functions of ferritins from animal and plant sources have been extensively studied in several fields, such as food, nutrition, medicine, and materials. This review outlines the structure of animal and plant ferritin, the iron supplementation function of holo ferritin, and the delivery function of apo ferritin. Recent advances in iron supplementation and nutrient encapsulation and delivery are highlighted. Finally, the current challenges and future developments for multifunctional applications of ferritins are discussed.
Lightweight Fine-Grained Multiowner Search over Encrypted Data in Cloud-Edge Computing
Authors: Liu XueYan , Huan LiJuan , Sun RuiRui , Wang Jing
Published: January 2023

Edge computing, as an extension of cloud computing, outsources encrypted sensitive data to edge nodes to decrease latency and improve broadband efficiency. Although attribute-based keyword search (ABKS) can ensure the security of outsourced data and promote fine-grained access control of data, deficiencies still exist under the general ABKS scheme in the cloud, as follows: shared files owned by a single data owner, inflexible access control, key escrow problem, and high computational overhead. We propose an attribute-based multidata owner searchable encryption scheme in cloud-edge computing with effective policy update to address these problems. The two-level access control is used to realize the common management and fine-grained sharing of data by the multidata owner. All user keys are jointly generated by the central authority and attribute authority, and a key escrow is no longer required. Moreover, partial encryption and decryption calculations are shifted from resource-constrained data owners and users to edge nodes. Furthermore, our scheme not only supports policy update but also realizes the dynamic updating of the index. The security proof and performance analysis show that the scheme has strong security and practicality in the edge computing environment.
Evaluation of Cottonseed Meal as an Alternative to Fish Meal in Diet for Juvenile Asian Red-Tailed Catfish Hemibagrus wyckioides
Authors: Li Biwei , Su Linhai , Sun Yan , Huang Han , Deng Junming , Cao Zhiyong
Published: January 2023

A 10-week trial was performed to investigate the effects of replacing fishmeal with cottonseed meal (CSM) on the growth rate, protein metabolism, and antioxidant response of Asian red-tailed catfish Hemibagrus wyckioides. Five isonitrogenous and isocaloric diets (C0, C8.5, C17.2, C25.7, and C34.4) were prepared to contain 0%, 8.5%, 17.2%, 25.7%, and 34.4% CSM replacing fishmeal, respectively. The weight gain, daily growth coefficient, pepsin, and intestinal amylase activities initially increased and then decreased with the raising dietary CSM levels; the highest values were observed in the C17.2 group (

P
<
0.05

). However, feed cost exhibited the opposite trend. With the increasing dietary CSM levels, the protein efficiency ratio and intestinal trypsin activity decreased but feed conversion rate increased gradually; while no differences were observed among the C0, C8.5, and C17.2 groups (

P
>
0.05

). Dietary CSM inclusion regardless of levels increased the plasma growth hormone level as well as hepatic aspartate aminotransferase (AST) and γ-glutamyl transpeptidase activities but decreased the plasma glutamate dehydrogenase and AST activities (

P
<
0.05

). With the increasing dietary CSM levels, the plasma alkaline phosphatase (AKP) and hepatic superoxide dismutase activities decreased but malondialdehyde content increased gradually, while no differences were observed among the C0, C8.5, and C17.2 groups (

P
>
0.05

). The plasma immunoglobulin M content and hepatic glutathione reductase activity initially increased but then decreased with the raising dietary CSM levels; the highest values were found in the C17.2 group. These results indicated that dietary CSM inclusion level up to 17.2% improved the growth rate, feed cost, digestive enzyme activity, and protein metabolism without compromising antioxidant capacity of H. wyckioide, whereas these parameters were depressed by further inclusion of CSM. CSM is a potentially cost-effective alternative plant protein source in diet of H. wyckioide.
Effect of T‐Stress on Crack‐Tip Stress Field and Crack Propagation of Concrete
Authors: Zhou Shaoqing , Li Limin
Published: January 2023

In order to predict the fracture toughness and propagation of the mixed mode fracture of concrete, the modified MTS (maximum tangential stress) criterion combined with T‐stress was presented. The modified MTS criterion uses a two‐parameter model (stress intensity factor K and T‐stress) to describe the concrete’s fracture. Through calculation, it is found that T‐stress can affect the maximum tangential stress, especially when T‐stress is negative. T‐stress is not taken into account in the traditional MTS criterion, which will lead to errors in calculating the maximum circumferential stress. The result of the specimen is not consistent with the predicted result of the traditional MTS. The modified criterion can provide accurate predictions for the experimental results. This provides a basis for the simulation of concrete’s fracture.
Phytochemical Screening, Toxic Effects, and Antimicrobial Activity Studies of Digitaria abyssinica (Hochst. ex A.Rich.) Stapf (Poaceae) Rhizome Extracts against Selected Uropathogenic Microorganisms
Authors: Sapunyo William Lemayian , Mbaria James Mucunu , Kanja Laetitia Wakonyu , Omolo Meshack Juma , Onyancha Jared Misonge
Published: January 2023

In Kenya, the D. abyssinica rhizome’s decoction is traditionally used to treat urinary tract infections (UTIs), mainly gonorrhea and candidiasis. UTIs are the most severe public health problems that affect over one hundred and fifty million people worldwide annually. They are caused by a wide range of microorganisms where Escherichia coli is known to be the main causative pathogen. Medicinal plants are used in traditional Kenya set up for treatment and most recently as an alternative source of treatment for UTIs due to the increased cost of treatment and many challenges experienced with antibiotic therapy. The current study is designed to investigate the phytochemical composition, acute oral toxicity, and antimicrobial activity of Digitaria abyssinica rhizome extracts against Staphylococcus aureus, Escherichia coli, Neisseria gonorrhea, and Candida albicans. The rhizomes of D. abyssinica were obtained, dried, ground, and extracted using water and organic solvents. The phytochemical assay was carried out using standard phytochemical screening methods. Single‐dose toxicity studies were done to determine LD50 while disk diffusion and microbroth dilution techniques were used to determine antimicrobial activity. Results revealed that saponins, phenolics, alkaloids, cardiac glycosides, tannins, flavonoids, steroids, and terpenes were present in the powder, aqueous, methanol, and dichloromethane : methanol extracts. All the extracts had an LD50 of above 2,000 mg/kg of body weight and there was no observation of behavioral changes. Also, the aqueous and methanol extracts revealed antifungal activity against Candida albicans with the lowest average minimum zone of inhibition at MIC of 31.25 mg/ml. The study did not reveal antibacterial activity for any extract against the studied uropathogenic bacteria, Staphylococcus aureus, Escherichia coli, and Neisseria gonorrhoeae. The results from the current study suggested that D. abyssinica rhizome aqueous and methanol extracts have potential antifungal activity against C. albicans, thus validating the folklore of its use to treat candidiasis.
Operation and Testing of Indirect Field Oriented Control of Asymmetrical Six-Phase Open-Ended Winding Induction Machine Using Hardware-in-Loop (HIL) Emulator
Authors: Iqbal Arif , Bakhsh Farhad Ilahi , Singh Girish Kumar
Published: January 2023

This study deals with an asymmetrical six-phase open-ended winding induction machine in closed loop operation using indirect field-oriented control scheme. The closed loop scheme has been developed by using the two axis (d-q) modeling of six-phase induction machine in rotating synchronous reference frame and can be easily extended to any multiphase machine having the stator winding which are the multiple of three. Operation under steady-state is considered to develop the phasor diagram in closed loop operation of machine in the motoring mode. The performance of the asymmetrical six-phase induction machine (opened ended winding) is investigated in the entire four-quadrant operation. The complete machine drive system was developed by using MATLAB/Simulink, which was used to obtain analytical results in different modes. Furthermore, the analytical results in the motoring mode were experimentally validated through real-time simulation by using Typhoon hardware-in-loop (HIL) emulator.
Microalgae as Raw Materials for Aquafeeds: Growth Kinetics and Improvement Strategies of Polyunsaturated Fatty Acids Production
Authors: Soto-Sánchez Oscar , Hidalgo Pamela , González Aixa , Oliveira Patricia E. , Hernández Arias Adrián J. , Dantagnan Patricio
Published: January 2023

Studies have shown that ancient cultures used microalgae as food for centuries. Currently, scientific reports highlight the value of nutritional composition of microalgae and their ability to accumulate polyunsaturated fatty acids at certain operational conditions. These characteristics are gaining increasing interest for the aquaculture industry which is searching for cost-effective replacements for fish meal and oil because these commodities are one of the most significant operational expenses and their dependency has become a bottleneck for their sustainable development of the aquaculture industry. This review is aimed at highlighting the use of microalgae as polyunsaturated fatty acid source in aquaculture feed formulations, despite their scarce production at industrial scale. Moreover, this document includes several approaches to improve microalgae production and to increase the content of polyunsaturated fatty acids with emphasis in the accumulation of DHA, EPA, and ARA. Furthermore, the document compiles several studies which prove microalgae-based aquafeeds for marine and freshwater species. Finally, the study explores the aspects that intervene in production kinetics and improvement strategies with possibilities for upscaling and facing main challenges of using microalgae in the commercial production of aquafeeds.
Primary Cardiac Lymphoma Presenting with Thrombocytopenia, Right Heart Failure, and Cardiogenic Shock
Authors: Kurniawan Samantha , Mathur Gita , Bogun Yvonne , Kidson-Gerber Giselle
Published: January 2023

Primary cardiac lymphoma (PCL) is a rare, potentially fatal subtype of non-Hodgkin’s lymphoma. Thrombocytopenia has also infrequently been reported in association with other primary cardiac tumours and can add substantial morbidity to an already life-threatening diagnosis if present. We report a rare case of a 70-year-old man who presented with thrombocytopenia (91 × 109/L) and progressive right heart failure. Transthoracic echocardiogram revealed a large 8 × 4 cm right atrial mass with severe tricuspid obstruction, confirmed as PCL on subsequent endomyocardial biopsy and immunohistochemistry. He deteriorated into cardiogenic shock precipitated by atrial fibrillation, with worsening thrombocytopenia (18 × 109/L) in the setting of ischaemic hepatitis. The patient stabilised with initiation of high dose steroids prior to tissue diagnosis and platelet counts normalised following chemotherapy. This case demonstrates the importance of considering PCL as a diagnosis and preemptive initiation of high dose steroids to improve outcomes in PCL associated with cardiogenic shock. This case also elucidates a potential pathophysiological association between PCL and thrombocytopenia.
Effect of Feeding Acid Oils on European Seabass Fillet Lipid Composition, Oxidative Stability, Color, and Sensory Acceptance
Authors: Albendea Paula , Tres Alba , Rafecas Magdalena , Vichi Stefania , Sala Roser , Guardiola Francesc
Published: January 2023

Acid oils (AO) are fat by-products of edible oil refining with a high energetic value, being an interesting option for a more sustainable aquaculture nutrition. This study was conducted to evaluate the effects of the partial replacement of fish oil (FO) in diets by two AO instead of crude vegetable oils on the lipid composition, lipid oxidation and quality of fresh European seabass fillets, and after their commercial refrigerated storage for 6 days. Fish were fed with five different diets, the added fat being FO (100%) or a blend of FO (25%) and another fat (75%): crude soybean oil (SO), soybean-sunflower acid oil (SAO), crude olive pomace oil (OPO), or olive pomace acid oil (OPAO). Fresh and refrigerated fillets were assessed for fatty acid profile, tocopherol (T) and tocotrienol (T3) composition, lipid oxidative stability, 2-thiobarbituric acid (TBA) value, volatile compound content, color, and sensory acceptance. Refrigerated storage did not affect T + T3 total content but increased secondary oxidation products (TBA values and volatile compound contents) in fillets from all diets. The FO substitution decreased EPA and DHA and increased T and T3 in fish fillets, but the recommended human daily intake of EPA plus DHA could still be covered with 100 g of fish fillets. Both a higher oxidative stability and a lower TBA value were found in SO, SAO, OPO, or OPAO fillets, obtaining the greatest oxidative stability in OPO and OPAO fillets. Sensory acceptance was not affected by the diet or the refrigerated storage, while the differences found in color parameters would not be perceived by the human eye. According to the oxidative stability and acceptability of flesh, SAO and OPAO are adequate replacements of FO as energy source in European seabass diets, which implies that these by-products can be upcycled, improving the environmental and economical sustainability of aquaculture production.
FTY720 Attenuates LPS-Induced Inflammatory Bone Loss by Inhibiting Osteoclastogenesis via the NF-κB and HDAC4/ATF Pathways
Authors: Chen Chongwei , Zong Sujing , Wang Zhenyu , Yang Ruijia , Guo Yanjing , Wang Yunfei , Chen Xinping , Li Yue , Wang Shaowei
Published: January 2023

Osteoclast (OC) abnormalities lead to many osteolytic diseases, such as osteoporosis, inflammatory bone erosion, and tumor-induced osteolysis. Exploring effective strategies to remediate OCs dysregulation is essential. FTY720, also known as fingolimod, has been approved for the treatment of multiple sclerosis and has anti-inflammatory and immunosuppressive effects. Here, we found that FTY720 inhibited osteoclastogenesis and OC function by inhibiting nuclear factor kappa-B (NF-κB) signaling. Interestingly, we also found that FTY720 inhibited osteoclastogenesis by upregulating histone deacetylase 4 (HDAC4) expression levels and downregulating activating transcription factor 4 (ATF4) expression levels. In vivo, FTY720 treatment prevented lipopolysaccharide- (LPS-) induced calvarial osteolysis and significantly reduced the number of tartrate-resistant acid phosphatase- (TRAP-) positive OCs. Taken together, these results demonstrate that FTY720 can inhibit osteoclastogenesis and ameliorate inflammation-induced bone loss. Which may provide evidence of a new therapeutic target for skeletal diseases caused by OC abnormalities.
Computational Optimal Impact Angle Control Guidance Laws Weighted by Arbitrary Functions
Authors: Chen Qi , Shi Jinguang , Wang Zhongyuan
Published: January 2023

This paper presents a computational impact angle control guidance law based on the energy cost weighted by arbitrary functions in order to shape the acceleration command as desired. The optimal guidance problem is established in the impact angle frame and is solved by the Gauss orthogonal collocation method. The proposed guidance law is formulated from the generalized optimal control framework, thus a new guidance law that allows achieving a specific guidance goal can be easily obtained in the way of devising a proper weighting function (smooth, piecewise, nonsmooth, or even discontinuous). This property provides more degrees of freedom in the guidance law design to accomplish a specified guidance objective. A hardware experiment is conducted to evaluate the real-time computational capacity of the proposed computational guidance law. Illustrative examples with several types of weighting functions, including smooth, piecewise, nonsmooth, and discontinuous functions, are provided to demonstrate the advantages and capacity of the proposed guidance law.
Calreticulin Expression Controls Cellular Redox, Stemness, and Radiosensitivity to Function as a Novel Adjuvant for Radiotherapy in Neuroblastoma
Authors: Chen Chih-Jung , Hu Ya-Chuan , Chien Yueh , Huang Wei-Chieh , Wu Chi-Sheng , Tsai Chung-Ying , Lin Yang-Hsiang , Lee Meng-Shiue , Chien Chian-Shiu , Yang Yi-Ping , Lee Meng-Chou , Tseng Chung-Chih , Chi Hsiang-Cheng
Published: January 2023

Radiotherapy (RT) is currently only used in children with high-risk neuroblastoma (NB) due to concerns of long-term side effects as well as lack of effective adjuvant. Calreticulin (CALR) has served distinct physiological roles in cancer malignancies; nonetheless, impact of radiation on chaperones and molecular roles they play remains largely unknown. In present study, we systemically analyzed correlation between CALR and NB cells of different malignancies to investigate potential role of CALR in mediating radioresistance of NB. Our data revealed that more malignant NB cells are correlated to lower CALR expression, greater radioresistance, and elevated stemness as indicated by colony- and neurospheroid-forming abilities and vice versa. Of note, manipulating CALR expression in NB cells of varying endogenous CALR expression manifested changes in not only stemness but also radioresistant properties of those NB cells. Further, CALR overexpression resulted in greatly enhanced ROS and led to increased secretion of proinflammatory cytokines. Importantly, growth of NB tumors was significantly hampered by CALR overexpression and was synergistically ablated when RT was also administered. Collectively, our current study unraveled a new notion of utilizing CALR expression in malignant NB to diminish cancer stemness and mitigate radioresistance to achieve favorable therapeutic outcome for NB.
Bioinformatics Analysis of Immune Cell Infiltration and Diagnostic Biomarkers between Ankylosing Spondylitis and Inflammatory Bowel Disease
Authors: Zhang Xuhong , Chen Tao , Qian Xian , He Xiaojin
Published: January 2023

Background. Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are both autoimmune diseases, and they often occur together in clinical practice, but the pathogenesis is unclear. This study is aimed at identifying the hub genes and explore the related immune molecular mechanisms between AS and IBD by bioinformatics analysis. Methods. From the public Gene Expression Omnibus (GEO) database, the AS and IBD datasets (GSE73754, GSE59071, GSE25101, and GSE36807) were obtained. The immune cell infiltration in the peripheral blood tissues of GSE73754 and GSE59071 was assessed using the CIBERSORT algorithm. Then, we used the Weighted Gene Coexpression Network Analysis (WGCNA) to identify the Differentially Expressed Genes (DEGs) related to AS and IBD. Then, the immune genes from the ImmPort database intersected with the DEGs to obtain hub genes. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyzed the functional correlation of hub genes. Then, hub genes were verified in GSE25101 and GSE36807. The clusterProfiler software and Gene Set Enrichment Analysis (GSEA) were used to conduct functional enrichment and pathway enrichment studies. Finally, the diagnostic efficacy was assessed using Receiver Operating Characteristic (ROC) curve analysis. Results. The analysis of immune characteristics showed that both AS and IBD were related to immunity, and neutrophils were positively correlated in both diseases. Nine coexpressed genes, including FCGRT, S100A11, IFNGR1, NFKBIZ, JAK2, LYN, PLAUR, ADM, and IL1RN, were linked to immune cells. The GO and KEGG analyses results showed that enrichment analysis was mainly related to cell transport and migration. Finally, the ROC curve was verified with the validation set, and it was found that PLAUR has clinical diagnostic significance and the most excellent specificity and sensitivity, respectively. Conclusions. PLAUR (uPAR) is a promising biomarker and will be an underlying genetic biomarker for diagnosing AS comorbid IBD. Inflammation and immunological modulation mediated by neutrophil infiltration were important in the development of AS and IBD and may be diagnostic and therapeutic targets.
Pembrolizumab Induced Calcitriol-Mediated Hypercalcemia
Authors: Oommen Tiffany T. , Sun Kelly , Barranco-Trabi Javier , Berenberg Jeffrey , Kim Myungjin
Published: January 2023

PD-1/PD-L1 inhibitors such as pembrolizumab have radically improved the prognosis for many patients with advanced malignancies. Although revolutionary, its use can be complicated and limited by various immune-related adverse effects. Effective management depends on early recognition and prompt intervention. Herein, we describe a unique syndrome of hypercalcemia, with associated acute renal injury and hypoxic respiratory failure that was responsive to corticosteroids suggestive of immunotoxicity from pembrolizumab.
Modelling, Analysis, and Simulation of Measles Disease Transmission Dynamics
Authors: Alemneh Haileyesus Tessema , Belay Asnakew Mesele
Published: January 2023

Measles is one of the top communicable diseases, which is still responsible for 2.6 million deaths every year. Due to this reason, the paper focuses on measles transmission dynamics concerning the impact of indirect contact rate (transmitted from the host of the virus to the healthy individual) and improving the SEVIR model into the SVIRP model. From the model, we first estimated the disease-free equilibrium, calculated the effective reproduction numberREff, and established the stability analysis. The Castillo–Chavez stability criterion is used to demonstrate the global stability of the disease-free equilibrium point, while the linearization method is used to justify its local stability analysis and gives a result REff<1. The stability analysis of endemic equilibrium point is explained by defining a Lyapunov function, and its global stability exists whenREff> 1. To identify the effect of parameters on the transmission dynamics, we performed sensitivity index and numerical simulation. From the result, we obtained that the indirect contact rate has the highest impact in maximizing the transmission dynamics of measles. Also, we found that working on prevention and treatment strategies brings a significant contribution in reducing the disease effect in the community.
Patient Blood Management in Pregnancy
Authors: Kaserer Alexander , Castellucci Clara , Henckert David , Breymann Christian , Spahn Donat R.
Published: January 2023

Background: Patient blood management (PBM) is a multidisciplinary and patient-centered treatment approach, comprising the detection and treatment of anemia, the minimization of blood loss, and the rational use of allogeneic transfusions. Pregnancy, delivery, and the puerperium are associated with increased rates of iron deficiency and anemia, which correlates with worse maternal and fetal outcomes and places pregnant women at increased risk of obstetric hemorrhage. Summary: Early screening for iron deficiency before the onset of anemia, as well as the use of oral and intravenous iron to treat iron deficiency anemia, has been shown to be beneficial. Anemia in pregnancy and the puerperium should be treated according to a staged regimen, administering either iron alone or in combination with an off-label use of human recombinant erythropoietin in selected patients. This regimen should be tailored to the needs of each individual patient. Postpartum hemorrhage (PPH) accounts for up to one-third of maternal deaths in both developing and developed countries. Bleeding complications should be anticipated and blood loss reduced by interdisciplinary preventive measures and individually tailored care. It is recommended that facilities have a PPH algorithm, primarily focusing on prevention through use of uterotonics, but also incorporating early diagnosis of the cause of bleeding, optimization of hemostatic conditions, timely administration of tranexamic acid, and integration of point-of-care tests to support the guided substitution of coagulation factors, alongside standard laboratory tests. Additionally, cell salvage has proven beneficial and should be considered for various indications in obstetrics including hematologic disturbances, as well as various forms of placental disorders. Key Message: This article reviews PBM in pregnancy, delivery, and the puerperium. The concept comprises early screening and treatment of anemia and iron deficiency, a transfusion and coagulation algorithm during delivery, as well as cell salvage.
Industry Partners’ Feedback on Students’ On-The-Job Training: Basis for Curriculum Enhancement and Intervention
Authors: Bentor Claire Theresa S. , Sabonsolin John Cavin M. , Niez Roland A.
Published: January 2023

Training effectiveness is measured by observable changes in knowledge, skills, and attitude after training has been conducted. This study investigates the industry partners' feedback on the On-the-Job training of the Bachelor of Arts in Communication and Bachelor of Arts in Economics interns. The researchers utilized the mixed method approach using the embedded research design. The researchers used the retrospective -descriptive quantitative design for the quantitative data. 40 practicum students' performances were evaluated during their on-the-job training for the School Year 2019 – 2020. Data were analyzed and presented using statistic numerical measures, and the relationship of variables was tested using spearman's rank-order correlation coefficient at a 0.05 significant value. Moreover, the researchers used thematic analysis of Braun and Clarke (2006) for the qualitative data. Results show that there is enough evidence to suggest that there is no statistically significant correlation between the profile of the students and their performance in practicum at α=0.05. Based on these findings, it is inferred that the students’ sex and course have no bearing on their shown knowledge and attitude, punctuality and active presence, performance proficiencies, and interpersonal interactions abilities at work. It is also found out that the industry partners noted strengths and weaknesses to the practicum students. This study discovered that the industry partner perceived the practicum students' performance to be competent in actual practice. Additionally, these findings pave way for the Economics and Communication department to select, develop, arrange, and implement meaningful classroom activities that promote sociability and prepare students for future careers.
Teaching Strategies and Students’ Performance in Mathematics in a Borderless Classroom
Authors: Roblon Angelie , Cano Jr. Alfredo , Miñoza Grechel , Recomo Jenybabe , Monares Jhetier , Arriola Mark Angelo , Polancos Queenie
Published: January 2023

As the educational sector shifted from traditional to borderless classrooms, having discussions through virtual platforms became the most popular option to keep the learning going amid the pandemic. This study investigated the teaching strategies of mathematics college instructors in college on the second-year mathematics students’ performance in borderless classrooms. It also determined how well the mathematics instructors adjusted to the situation, as evidenced by how and what teaching strategies they used in their classes. Fifteen mathematics instructors were recruited for the study using a random sampling technique. Findings revealed that some teachers were unfamiliar with various tools and platforms. Using the Pearson correlation coefficient, there is a significant positive relationship between the teaching strategies in the borderless classrooms and the student’s performance in mathematics r (13) = .49, p< .04. The Strategic Intervention Applied in Asynchronous Teaching (SIAAT) was proposed by which will ensure that students will continue to receive asynchronous learning in borderless classrooms.
Primary Mathematics School Teachers’ Technological, Pedagogical and Content Knowledge and Learners’ Achievement
Authors: Patalinghug Janiene T. , Arnado Alvic A.
Published: January 2023

The goal of this study is to determine the level of primary mathematics school teacher’s Technological Pedagogical and Content Knowledge (TPACK) and the achievement of learners of the selected districts of the Division of Butuan City, Agusan del Norte. The participating teachers were able to complete the survey on the following components namely, technology knowledge, content knowledge, pedagogical knowledge, pedagogical content knowledge, technological pedagogical knowledge, technology and pedagogy and content knowledge, and the mathematics achievement level of learners. This study employed descriptive – correlational design to describe the variables and the relationship among them. The results revealed that teachers have high knowledge on the seven components of TPACK and obtained highest average on the technological pedagogical knowledge directly proportional with the mathematics achievement level of the learners. Though teachers showcasing their mastery level of teaching, still they need the support of technology to address the immediate concerns in dealing with the new normal. Thus, teachers may be encouraged to attend conferences, seminar – workshops, and training related to technology specifically training on technology applications that promotes easy techniques in solving word problems in primary grade mathematics.
Understanding Gender Roles among Microenterprises: An Emphasis on Entrepreneurial Activities
Authors: Mendoza Xavier Lawrence , Tadeo Jerico B.
Published: January 2023

Entrepreneurship has proven to become a potent economic opportunity augmenting activity that transcends the economic status quo, social strata, and even gender classification. Hence, the researchers aimed to understand gender roles among micro-enterprises in General Trias City and Tanza, Cavite, as a baseline study in undertaking gender-sensitive approach analysis to the enterprise. The study used descriptive design and purposive sampling methods in selecting 30 female and 30 male respondents in General Trias City and Tanza, Cavite. Findings showed that microenterprise business owners were dominated by 20 to 23 years old in both sexes, mostly single college undergraduates and having more than three years in operation. The study revealed the majority of male and female participants answered variably concerning gender roles among entrepreneurs in terms of; conflict management, mindset creation, emotion setting, planning, leading, organizing, controlling, and directing. On the other hand, 60 participants answered variably in participation roles among entrepreneurs in terms of; conflict management, mindset creation, emotion setting, planning, leading, organizing, controlling, and directing. Hence, the researchers' recommendations arrived at through gender roles analysis using the gender role attitude scale and degree of gender participation-role among entrepreneurs crafted towards the promotion of harmonious activities within enterprises concerning specific gender roles and their respective enterprise activities.
Study of Physical and Mineral Properties of Soil Clay Landslide Location of IAIN Campus Ambon City
Authors: Luhukay Marcus , Risamasu Robby G. , Osok Rafael M , Slamet Sonya
Published: January 2023

This study aims to determine physical and clay mineral properties of soils and how they affect the occurrence of erosion in the IAIN Campus Ambon. The results indicated that the two soil profiles shows a variety in soil properties. the largest distribution of soil particle density is 2.63 at soil layer P2L3 and the smallest is 2.26 at P1L1, the largest soil pore distribution is 60.12% at P2L1 and the smallest is 29.36% at P1L3, while the largest soil pores ratio distribution is 1.51% at P2L1 and the smallest is 0.42% at soil layer P1L3. The soil porosity reflects the level of the soil ability to pass water flow (permeability) or the speed of water flow to pass through the soil mass (percolation). By the decreasing of soil porosity and pore ratio in layers 3 and 4, the permeability is also slower. The major clay mineral found in both soil profiles is kaolinite, an unwell consolidated secondary clay mineral type 1:1 mixed with quartz, the most weathering resistant primary minerals. These two minerals have lower friction resistance due to the increasing of clay content in the lower soil profiles. The physical and hydrological soil properties as well as the presence of kaolinite and quartz in the lower soil layers are considered to be the cause of the erosion occurrence in the study area (IAIN campus).
Students’ And Teachers’ Perspectives on ICT Integration in Learning Process During Pandemic
Authors: Tayaban Alma D.
Published: January 2023

Information and Communication Technology (ICT) integration allows educators to update traditional coaching to meet the global demand for fully technology-based coaching and mastering equipment and learning tools.

This study wants to identify students and teachers’ perceptions on how effective ICT integration is in supporting the teaching and learning process in the classroom.

The researcher used quantitative methodology, developed survey questionnaire and administered to target respondents in the three campuses of Ifugao State University. Respondents were composed of 66 Education students and 35 faculty members. The data for this quantitative study was examined using descriptive and inferential statistics.

It was found out that most teachers and students agreed on the effectiveness of ICT integration in the teaching and learning process. The findings showed that ICT integration is beneficial for teachers teaching quality, improve learning materials and motivate students to be more creative and imaginative. Thus, learning and teaching become effective with ICT integration.

Based on the results, it is recommended that for teachers, a digital literacy assessment may be administered to the teachers, after which a series of hands on activities will be conducted. For students, in order to derive the maximum effect regarding the use of ICT in learning, an action research may be conducted first among students to identify and solve issues on the use and challenges of ICT in teaching and learning.
The Efficiency of Hand Tricks in Learning Trigonometric Ratios
Authors: Delima Christian M.
Published: January 2023

This study investigated how hand tricks influenced the students' achievement in trigonometric ratios. Using a quasi-experimental design and purposive sampling, twenty students were the survey respondents: ten of whom took as a control group, and ten took as an experimental group. Through limited face-to-face classes, the researcher selected respondents from Grade 9 students at Bonifacio National High School. The research instruments used in this study are two sets of lesson plans, a pretest, and a post-test. The study revealed that the traditional method and hand tricks effectively teach trigonometric ratios. However, results also found that it was more effective to teach trigonometric ratios when using the hand tricks. The study concluded that the traditional and hand tricks were considered effective in teaching trigonometric ratios. Though, those students who participated in the use of hand tricks in teaching performed better in solving trigonometric ratios than those students who trained using the conventional method. The use of hand tricks helps students with difficulty in memorizing trigonometric ratios. The researcher recommended that we always use hand tricks in teaching trigonometric ratios. It is also recommended for complete and thorough teaching of mathematics topics throughout the year to reinforce mathematics teaching and learning. Moreover, hand tricks are used in learning trigonometric ratios and preparing for advanced trigonometric lessons.