bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of quantitative lung computed tomographic findings between idiopathic pulmonary fibrosis patients diagnosed by biopsy and by multidisciplinary discussion without biopsy
Authors: GÖKÇEK Atila
Published: June 2022

Objectives: We aimed to investigate the objective quantitative differences between the parenchymal computed tomography (CT) findings of idiopathic pulmonary fibrosis (IPF) patients diagnosed by surgical lung biopsy and by multidisciplinary discussion without biopsy.
Methods: We performed parenchymal texture analyses in lung CT images of 116 IPF patients, 42 diagnosed by surgical lung biopsy, and 74 by multidisciplinary discussion without biopsy. The relative volumes of the ground-glass, reticular, honeycomb, hyperlucent, and normal parenchymal patterns were measured in six predefined sections of each lung by an automatic texture analysis software (CALIPER: Computer-Aided Lung Informatics for Pathology Evaluation and Rating). The results were compared between the two patient groups.
Results: When the relative volumes of the parenchymal patterns were compared between the biopsied and non-biopsied groups in a total lung-based manner, the mean percentage of only the ground-glass pattern was significantly higher in the biopsied group. When compared between the corresponding lung sections, the percentages of the ground-glass pattern were higher in the biopsied group than those in the non-biopsied group at the bilateral central sections of the upper, middle, and lower lung zones. At the bilateral peripheral sections of the middle and lower lung zones, the sectional reticular pattern percentages were lower in the biopsied group than those in the non-biopsied group.
Conclusions: CALIPER’s quantitative CT measurements revealed that the sectional relative volumes of the ground-glass and reticular patterns, but not of the honeycomb, normal, and hyperlucent parenchyma, were significantly different between some of the corresponding lung sections of the biopsied and non-biopsied IPF patients. This information may help a better understanding of the role of the CT findings in biopsy decisions and avoiding some of the unnecessary biopsies in suspected IPF patients.
Remoción de capas para mejorar la apariencia y calidad de la cebolla
Authors: Barrales Heredia Susana Marlene , Grimaldo Juárez Onecimo , Suárez Hernández Angel Manuel , Soto Ortiz Roberto , González Mendoza Daniel , Avendaño Reyes Leonel
Published: June 2022

La remoción de capas en la cebolla es una práctica común en mercados para mejorar la apariencia y calidad del producto durante el mercadeo. El objetivo de la investigación fue evaluar el efecto de la remoción de capas (C0=sin remoción, C1=sin una capa y C2=sin dos capas) sobre la calidad físico-química de la cebolla expuesta a condiciones ambientales por periodos de 0, 10, 20 y 30 días. Se evaluaron 12 tratamientos en un diseño completamente al azar. Los resultados mostraron que las variables materia seca, firmeza y saturación de color (C*) no son afectadas por la interacción de la remoción de capas y tiempo de exposición. Las variables ángulo hue, luminosidad (L*), sólidos solubles, acidez titulable y pH, mostraron variación significativa con la interacción del tiempo de exposición y nivel de remoción de capas. El nivel de variación de los tratamientos no mostró un patrón definido a excepción de la tonalidad de la coloración de la cebolla (hue). El valor de hue se incrementó en los tratamientos con mayor nivel de remoción de capas, manifestándose tonalidades hacia el color verde con la eliminación de dos capas.
Rendimiento y valor nutritivo de cereales y cártamo forrajero en la Comarca Lagunera
Authors: Reta-Sánchez David Guadalupe , Ochoa Espinoza Xóchilt Militza , Cano Ríos Pedro , Sánchez Duarte Juan Isidro , Ochoa Martínez Esmeralda , García Martínez José Eduardo , Reyes González Arturo , Quiroga Garza Héctor Mario
Published: June 2022

El cártamo y los cereales como alternativas a la avena permiten incrementar el potencial forrajero en siembras tardías de otoño-invierno. El objetivo del estudio fue comparar el potencial forrajero y el valor nutritivo de cereales y cártamos con y sin espinas con los observados en avena en siembras tardías de otoño-invierno. El estudio se realizó en los ciclos otoño-invierno de 2017-2018 y 2018-2019 en Matamoros, Coahuila, México. Se evaluaron cultivares de avena, cebada, trigo, triticale y cártamos con y sin espinas. Se utilizó un diseño de bloques completo al azar con cuatro repeticiones. Se determinó el valor nutritivo del forraje y los rendimientos de nutrientes. La cebada y el trigo aumentaron el potencial forrajero con la incidencia o no de enfermedades foliares en avena. Los incrementos fueron en producción de materia seca (MS) (26.3 a 39.0 %), proteína cruda (34.8 %), energía neta para lactancia (34.2 %) y MS digestible (29.4 a 34.8 %). Las especies triticale, trigo, cebada y cártamo también fueron buenas alternativas, pero sólo cuando los rendimientos de forraje en avena fueron reducidos por enfermedades foliares. El potencial forrajero puede incrementarse con especies alternativas a la avena en siembras tardías de otoño-invierno.
THE EFFECT OF THE EUCLIDEAN GEOMETRY SHORT LEARNING PROGRAMME USING THE WORKED-OUT EXAMPLES TEACHING APPROACH ON MATHEMATICS TEACHERS' PERFORMANCE
Authors: Rabaza Msebenzi , Hamilton Joleen
Published: June 2022

The studies on the worked-out examples teaching approach (WOETA) have been investigated globally and in South Africa, showing gains in learners' performance. This study reports on the Euclidean geometry short learning programme (EGSLP), which used worked-out examples teaching approach (WOETA) intervention to secondary mathematics teachers enrolled in one university campus in the Free State province. This study used one group pretest-posttest research design.65 participants completed the pre-test, participated in WOETA, and later completed the post-test. The WOETA engaged the participants in the Euclidean geometry six topics, straight-line geometry, classification of triangles, Pythagoras, similarity and congruency, properties of polygons, and measurement that helped them to acquire procedural and conceptual knowledge. The findings revealed that the WOETA improved the participants' performance in two topics, straight-line geometry and classification of triangles. In contrast, it failed in four topics Pythagoras, similarity and congruency, properties of polygons, and measurement. Cronbach alpha was used to calculate the reliability of the pre-test and was 0,52, while the post-test reliability was 0.30, and these values were deemed not acceptable and not reliable. The findings also revealed that the WOETA does not affect participants' Euclidean geometry performance.
PERUBAHAN KIMIA DAN MIKROBIOLOGI TEMPE BUSUK SELAMA FERMENTASI
Authors: Nuraini Vivi , Puyanda Irvia Resti , Kunciati Widasari Atrilania Sri , Margareta Laurensia Atha
Published: June 2022

Tempeh is a very popular food because it is delicious and has good nutritional value. Overfermented tempeh is used as a seasoning in dishes such as lodeh and sambal tumpang. Thus, it is necessary to know the length of time tempeh fermentation is safe for consumption. The purpose of this study was to determine the chemical and microbiological quality of over-fermented tempeh and the effect of the packaging used. This study used a 2-factor factorial completely randomized design. The first factor is the storage time of tempeh (1 day, 3 days, 5 days, 7 days, and 9 days), and the second factor is the type of tempeh packaging (plastic, teak leaves, and banana leaves). The results of the water content test showed that the tempeh began to decay in storage for 5 days. Teak leaf packaging has the lowest water content of the others. Tempeh, which has the highest protein content of 0.60 g/L, is tempeh packaged in teak leaves that has been stored for 3 days. Tempeh stored for 9 days has high water content, exceeding the maximum SNI standard (SNI 3144:2015) by about 65%. Soluble protein levels increased and then decreased during the decomposition process. Free fatty acids continued to experience a decrease in storage for 9 days, which indicated that the process of decay had occurred. The highest free fatty acids were found after 3 days of storage in plastic packaging, which reached 6.2 mg NaOH/g, while tempeh packaged with teak on the third day still showed a lower value of 3.83 mg NaOH/g. The total bacteria test showed an increasing trend from the first day to the ninth day of storage. Tempeh was still suitable for consumption up to five days after being stored. After 5 days of storage, tempeh has decreased in quality. Teak leaves have been proven to be able to maintain the quality of tempeh better than plastic packaging or banana leaf packaging.

Keywords: banana leaf, FFA (free fatty acid), teak leaf, tempeh
O desempenho de protetores solares fotovoltaicos integrados a edifícios institucionais
Authors: Santos Maurício Picetti dos , Santos Ísis Portolan dos , Salamoni Isabel Tourinho
Published: June 2022

A energia solar fotovoltaica é uma importante fonte de energia renovável que reduz o impacto ambiental e aproxima a geração elétrica das unidades de consumo, diminuindo as perdas na transmissão de energia. Além disso, as características geométricas dos módulos fotovoltaicos permitem a sua integração com a envoltória do edifício, estabelecendo componentes passivos para a promoção da eficiência energética. Quando instalados nas unidades consumidoras na forma de protetores solares, os módulos fotovoltaicos limitam os ganhos térmicos nos ambientes internos a partir do controle da incidência de irradiação solar, podendo também reduzir o consumo energético por climatização. Assim, este artigo avaliou o desempenho de propostas de protetores solares fotovoltaicos integrados ao edifício Instituto de Redes Inteligentes da Universidade Federal de Santa Maria quanto à geração de energia elétrica e a influência no consumo elétrico da edificação. Para isso, foi avaliada a geração energética do conjunto fotovoltaico, através de simulação no software PVsyst v6.8, e estimado o consumo energético na edificação no software DesignBuilder v6.1. A partir das simulações, verificou-se que os protetores solares fotovoltaicos, compostos por 34 módulos, apresentaram desempenho superior ao conjunto de mesma quantidade de módulos e instalado na cobertura do modelo virtual, desenvolvendo uma redução de 21,94 MWh/m².ano na resultante energética do modelo. Assim, a inserção de módulos fotovoltaicos na forma de protetores solares surge como alternativa para a integração em edificações com área de cobertura reduzida, apresentando geração similar aos sistemas tradicionais, além de permitir a diminuição do consumo elétrico.
O currículo de matemática do programa gestão da aprendizagem escolar
Authors: Almeida Laura Isabel Marques Vasconcelos de , Santos Elizaine  Vaz
Published: June 2022

Este artigo é parte da dissertação de mestrado e objetiva analisar os conteúdos do Programa Gestar I constituídos pelo Guia Geral, Cadernos de Psicopedagogia, Teoria e Prática (TP) e Atividades de Apoio à Aprendizagem (AAA), destinados à formação continuada de professores dos Anos Iniciais, no período de 2001 a 2004, com ênfase na disciplina de Matemática, nas regiões Norte, Nordeste e Centro-Oeste. A abordagem metodológica centra-se na vertente Histórico-Cultural e apontam vestígios das práticas do Programa que se baseiam nas habilidades e competências orientadas pelo Parâmetro Curricular Nacional de Matemática, entoando ações intrínsecas da disciplina desfazendo-se de práticas de memorização, utilizando a linguagem matemática, símbolos e representações que se unem ao pensamento da construção da aprendizagem com ênfase na prática social do aluno, uso de recursos didáticos e estratégias significativas organizadas pelo professor que possam ser apropriadas pelos alunos.
The Development of Practice Packages on Chinese Pronunciation Skills through Seesaw Online Classroom for Students Majoring in Chinese Language Teaching
Authors: Chanpeng Pantipa
Published: June 2022

This research aimed to 1) develop and measure the efficiency of a set of reading and pronunciation skills in Chinese phonetics via Seesaw online classroom; 2) examine the effectiveness of the set; and 3) evaluate students' satisfaction with practice packages on Chinese pronunciation via Seesaw online classroom. Thirty-six undergraduate students majoring in Chinese language teaching at a university in Thailand were the participants of this study. This study used descriptive statistics (mean and S.D.) and dependent samples t-test. The results of this research indicated a substantial increase in students' learning achievement due to the Seesaw online classroom. Additionally, the Development of Practice Packages for Chinese Pronunciation Skill Acquisition via Seesaw Online Classroom was greater (x̄=4.84, S.D.=0.37) than the researcher’s standard of 3.50, and achieved the efficiency standard criteria of 82.50/84.97, which was greater than the 80/80 efficiency standard criterion chosen. Students' satisfaction with learning was high when they utilized Seesaw's Chinese pronunciation practice packages (x̄= 4.50, S.D.= 0.54).
Gambaran Anak Korban Kekerasan Pada Tokoh Hye Na Dalam Drama Mini-series Korea Selatan Mother (2018)
Authors: Ramadhani Kania Salsabil
Published: June 2022

Penelitian ini membahas mengenai gambaran tokoh Hye Na yang merupakan anak korban kekerasan oleh ibu biologisnya sendiri dalam drama Korea Selatan Mother (2018). Penelitian ini merupakan penelitian kualitatif deskriptif dengan menggunakan metode analisis tekstual dengan melihat narasi dialog, pengadeganan, dan elemen lainnya serta konteks budaya untuk menghasilkan interpretasi terkait bagaimana tokoh Hye Na yang merupakan korban kekerasan anak yang digambarkan di dalam drama Mother (2018). Hasil dari penelitian ini menunjukkan bahwa tokoh Hye Na mengalami empat kategori kekerasan, yaitu kekerasan fisik, kekerasan emosional, penelantaran secara fisik, dan penelantaran secara emosional. Melalui tokoh Hye Na, sutradara dan penulis naskah ingin mendobrak mitos dimana anak korban kekerasan selalu berakhir negatif dan rusak. Anak korban kekerasan masih dapat tertolong dan masih memiliki masa depan selama anak tersebut dikemudian hari hidupnya dijamin oleh orang (attachment figure) yang tepat bagi dirinya, yang dapat memberikan dan menyediakan kehangatan, kasih sayang, dan melindunginya dari bahaya dan ketakutan. Tokoh Hye Na yang pada awalnya digambarkan sebagai sosok yang lemah dan tidak berdaya, kemudian perlahan mengalami pengembangan karakter ketika Hye Na berganti attachment figure. Tokoh Hye Na mengalami dua pola attachment yaitu disorganized dan avoidant attachment saat berada dalama asuhan Ja Young, sementara mengalami secure attachment saat berada dalam asuhan Soo Jin.
An Analysis of Failures and Practical Possibilities of Diagnosing IGBT Transistors in Converter Circuits of Marine Propulsion Systems
Authors: Gordon Radosław , Bejger Artur
Published: June 2022

The article presents the results of tests related to failure analysis and finding ways to diagnose used semiconductor elements, among other, in power electronics converter systems on vessels and offshore facilities (drilling and production rigs, wind turbines). Diagnostic relationships were found between the temperature change in the above systems and the signals generated in form of elastic waves of acoustic emission.
CARDIOSIM©: The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support
Authors: De Lazzari Beatrice , Badagliacca Roberto , Filomena Domenico , Papa Silvia , Vizza Carmine Dario , Capoccia Massimo , De Lazzari Claudio
Published: June 2022

This review is devoted to present the history of CARDIOSIM© software simulator platform, which was developed in Italy to simulate the human cardiovascular and respiratory system. The first version of CARDIOSIM© was developed at the Institute of Biomedical Technologies of the National Research Council in Rome. The first platform version published in 1991 ran on PC with disk operating system (MS-DOS) and was developed using the Turbo Basic language. The last version runs on PC with Microsoft Windows 10 operating system; it is implemented in Visual Basic and C++ languages. The platform has a modular structure consisting of seven different general sections, which can be assembled to reproduce different pathophysiological conditions. The software simulator can reproduce the most important circulatory phenomena in terms of pressure and volume relationships. It represents the whole circulation using a lumped-parameter model and enables the simulation of different cardiovascular conditions according to Starling’s law of the heart and a modified time-varying elastance model. Different mechanical ventilatory and circulatory devices have been implemented in the platform including thoracic artificial lung, ECMO, IABP, pulsatile and continuous right and left ventricular assist devices, biventricular pacemaker and biventricular assist devices. CARDIOSIM© is used in clinical and educational environment.
MiWEndo: Evaluation of a Microwave Colonoscopy Algorithm for Early Colorectal Cancer Detection in Ex Vivo Human Colon Models
Authors: Guardiola Marta , Dghoughi Walid , Sont Roberto , Garrido Alejandra , Marcoval Sergi , Neira Luz María , Belda Ignasi , Fernández-Esparrach Glòria
Published: June 2022

This study assesses the efficacy of a microwave colonoscopy algorithm to detect colorectal cancer precursors or polyps in an ex-vivo human colon model. The algorithm works with a device composed of a cylindrical ring-shaped switchable antenna array, which can be attached to the tip of a conventional colonoscope as an accessory. The accessory is connected to an external processing unit that generates an acoustic signal when a polyp is detected. Nowadays, 22% of polyps go undetected with conventional colonoscopy and the risk of cancer after a negative colonoscopy can be up to 7.9%. Fifteen ex-vivo freshly excised human colons with cancer (n=12) or polyps (n=3) were examined with the microwave-assisted colonoscopy system simulating a real colonoscopy exploration. Successive measurements of the colon were taken with the microwave-based colonoscopy device and processed with a microwave imaging algorithm. After the experiment, the dielectric properties of the specimens were measured with a coaxial probe and finally the samples underwent a pathology analysis. The results show that all the neoplasms were detected with a sensitivity of 100% and specificity of 87.4%.
Revisiting Regulated Cell Death Responses in Viral Infection
Authors: Rex Devasahayam Arokia Balaya , Keshava Prasad Thottethodi Subrahmanya , Kandasamy Richard K.
Published: June 2022

The fate of a viral infection in the host begins with various types of cellular responses, such as abortive, productive, latent, and destructive infections. Apoptosis, necroptosis, and pyroptosis are the three major types of regulated cell death mechanisms that play critical roles in viral infection response. Cell shrinkage, nuclear condensation, bleb formation, and retained membrane integrity are all signs of osmotic imbalance-driven cytoplasmic swelling and early membrane damage in necroptosis and pyroptosis. Caspase-driven apoptotic cell demise is considered in many circum-stances as an anti-inflammatory, and some pathogens hijack the cell death signaling routes to initiate a targeted attack against the host. In this review, we selected mechanisms by which viruses interfere with cell death are discussed in-depth and are used to illustrate the general principles and cellular signaling mechanisms of virus-host specific molecule interactions.
Euglenoid Flagellates in Ecotoxicological Research: Progress and Perspectives
Authors: Kottuparambil Sreejith
Published: June 2022

Euglenoids are a common component of primary producers in high acidic and organic shallow freshwater systems. They are free-living photosynthetic motile flagellates exhibiting rapid responses to various external stimuli including chemical pollution. The unique combination of diverse physiological processes of Euglena such as photosynthesis, movement, and orientation offers a range of sensitive criteria that respond to aquatic pollutants. This has led to the development of several acute and chronic assay methods to monitor the adverse impacts of potent toxicants in aquatic ecosystems. Euglenoids also reflect the consequences of physical stress factors such as UV radiation. This review summarizes the ecotoxicity studies using euglenoid flagellates as model species and their potential to contribute toward rapid screening of ecological impacts of pollution in the aquatic environment. Factors determining the reliability of Euglena tests are outlined.
Formation of Stable Gold Nanoparticles from Cannabis Indica Leaves
Authors: Khadria Anjul , Paul Subhankar
Published: June 2022

Gold nanoparticles have been increasingly used in several electronic, material fabrication, and biomedical applications. Several methods have been reported to prepare gold nanoparticles of various shapes and sizes with different photophysical properties. Although useful to prepare gold nanoparticles, most of the methods are not stable enough and under degradation if stored at room temperatures (up to 30 C) for a few days. In this paper, we report a novel environmentally friendly method to synthesize self-assembled gold nanoparticles by using leaf extract of Cannabis indica as a reducing agent. The nanoparticles were found to be stable for more than a month when stored at room temperature (30 C). They were able to form stable conjugates with bovine α-lactalbumin protein that may possess anti-cancerous properties.
Student worksheet based on Surakarta’s local wisdom in primary school: A preliminary research
Authors: Widyaningrum Ratna , Prihastari Ema Butsi
Published: June 2022

Student worksheets as one of the learning tools that should be developed by the teacher because textbooks from the government have minimal material. Student worksheets that are integrated with local wisdom can make learning more meaningful. This study aims to describe the results of the preliminary analysis consist of the 2013 curriculum learning process that is implemented in primary school at Banjarsari Surakarta, especially in terms of the needs of student worksheet in the learning process, the steps for making student worksheet based on Surakarta’s local wisdom, and analyzing local wisdom material that will be integrated into making student worksheet. This research used a qualitative descriptive approach. The research subjects were teachers and 5th-grade students, amounting to 2 teachers and 10 students. The sampling technique used was purposive sampling. Data collection techniques using interviews, observation, and documentation. Data validity uses source and method triangulation. Data analysis techniques include reduction, presentation, and conclusion. The results obtained are the teachers generally use simple student worksheets and haven’t been linked to local wisdom. The student worksheet format created only consists of work steps and assessments. The steps of making a student worksheet are curriculum analysis and local wisdom to be used, compiling, determining title, and writing. Local wisdom materials that can be integrated include Laweyan batik, Pasar Gede, medicinal plants, and the Javanese community farming system. The implication of this research is to provide meaningful learning resources for students and instill a sense of love for local culture.
The role of financial statements in predicting the changes of prices and production cost of oil
Authors:   Technical Institute Kut, Zwaid Jasim Gshayyish , Bari Ayad Hadi Abdul ,   Technical Institute Kut, Rashed Raed Naeem ,   Wasit University
Published: June 2022

Oil is considered a strategic commodity for the countries of OPEC - based on it determined the direction of economic and financial development. It is the most important source used by the country to implement its policy and economic programs. This study focused on accurately predicting future prices of OPEC’s oil drum and suggest suitable planning to avoid any economic financial due to oscillating oil prices. Also, is the financial statement have a role in increasing predict accuracy for oscillating oil’s prices. To achieve research goals and exam research hypothesis monitored oil price monthly for fifteen years from (1/1/2003-1/6/2020). The results data have two types of time series, therefore, analyzed by using MATLAB software. The results have linear and non-linear data; therefore, it needs software or more for processing to predict oil prices in the future. Linear data can be processed using one statistics model, ARIMA (2,2,1), to predict future oil prices. Many suggestions are introduced, among them must using a set of programs to process data of financial statements.
Circular bioeconomics: conceptual aspects
Authors:   A. Baitursynov Kostanay Regional University, Yessenbekova Zhibek , Turezhanov Seitkaliy ,   A. Baitursynov Kostanay Regional University
Published: June 2022

Сircular bioeconomics offers a conceptual framework for harnessing and managing renewable natural capital in the use of land, food, health care and industrial systems to achieve sustainable well-being in harmony with nature. This article considers a circular bioeconomy as more efficient than the traditional linear economy. Concepts that can break the causal relationship between economic progress and environmental degradation, when the destruction of nature will not be an obligatory price for further building up the economic potential of the country, the region and the world as a whole are considered in our research.
Investigation of program mechanisms efficiency for the small and medium-sized businesses development in Russia
Authors:   Vologda State Dairy Farming Academy named after N. V. Vereshchagin, Medvedeva Natalia , Shilova Irina ,   Vologda State Dairy Farming Academy named after N. V. Vereshchagin, Malygina Ekaterina ,   Emperor Alexander I St. Petersburg State Transport University
Published: June 2022

The study examines the improvement trends of small and medium-sized businesses in Russia by the year 2021. Measures of state support aimed at developing the entrepreneurship are outlined. The effective growth of entrepreneurship leads to the satisfaction of products, works, services, and new jobs. Support for small and medium-sized business entities in foreign countries is at a higher level than in Russia. This is due not only to the long period of formation of the market economy but also to the fact that foreign countries’ government attaches great importance to small forms of enterprises and supports them by implementing special programs and providing benefits. The study aims to evaluate the program mechanisms’ efficiency for developing small and medium-sized entrepreneurship in Russia. The authors substantiated a system of indicators characterizing state support’s socio-economic efficiency in consolidated blocks: entrepreneurial, budgetary, and social efficiency. A methodology for assessing state programs’ efficiency for developing small and medium-sized businesses, including integral indicators based on the standardization of entrepreneurial efficiency components, has been developed. This methodology makes it possible to identify the relationship between the social aspects of entrepreneurial activity and state support.
Market performance of SMEs in the creative economy and the mediating role of innovation practices
Authors:   Institute of Business and Technology Pelita Indonesia, Rahman Sarli , Budiyanto  ,   Sekolah Tinggi Ilmu Ekonomi Indonesia, Suwitho  ,   Sekolah Tinggi Ilmu Ekonomi Indonesia
Published: June 2022

Nowadays in Indonesia, the creative economy is currently expected to a new power that will be the Indonesian economic foundation in the future. The primary aim of this article is to investigate the market and the SMEs’ performance in the creative economy section and the mediating role of innovation practices until the year 2021. To meet that aim, the analysis technique called Structural Equation Modeling (SEM) assisted by AMOS 21 software is utilized through the survey of 300 SMEs. Structural Equation Modeling (SEM) is an integrated of factor or path investigation. The result of this study reveals that the most important factor that can improve the SMEs’ performance in the creative economy sector is innovation practices.
Project performance in a toll road infrastructure with a public-private partnership scheme
Authors:   Padjadjaran University, Nusriadi Laode , Avianti Ilya ,   Padjadjaran University, Tanzil Nanny Dewi ,   Padjadjaran University, Parikesit Danang ,   Gadjah Mada University
Published: June 2022

Public-private partnership (PPP) models were employed, especially in the toll road sector, by many governments to boost the development of the infrastructure and build strong connections among regions. PPPs are chosen as a scheme to fill the financial gap. Good project governance is one of the crucial points that should be supported by several significant factors, which will significantly affect projects’ performance. This study analyzes the influence of projects’ intellectual capital, investor protection mechanism, and ownership structure on the implementation of good project governance and the implications for their performance. The data were obtained through questionnaires sent to 43 public-private partnerships in toll road projects in Indonesia. The partial-least-square structural equation model (SEM) was subsequently employed to analyze the data. The study findings showed that (1) projects’ intellectual capital and ownership structure affect the implementation of good project governance, (2) the implementation of good project governance affects projects’ performance, and (3) projects’ intellectual capital and ownership structure affect their performance through the implementation of good project governance. However, the other five hypotheses investigated, namely those concerning projects’ intellectual capital, investor protection mechanism, ownership structure in project performance, investor protection mechanism for the implementation of good project governance, and project performance through the implementation of good project governance, were not supported. This study provides a knowledge basis enabling decision makers to understand precisely the factors that affect project performance through the implementation of good project governance.
Social and economic consequences of the influence of bronchospasm on health of children and adolescents in the context of public health management improvement
Authors:   I. M. Sechenov First Moscow State Medical University of Health of the Russian Federation (Sechenov University), Geppe Natalya , Farber Irina ,   I. M. Sechenov First Moscow State Medical University of Health of the Russian Federation (Sechenov University), Polyanskaya Angelina ,   I. M. Sechenov First Moscow State Medical University of Health of the Russian Federation (Sechenov University), Chebysheva Svetlana ,   I. M. Sechenov First Moscow State Medical University of Health of the Russian Federation (Sechenov University), Aksenova Marianna ,   I. M. Sechenov First Moscow State Medical University of Health of the Russian Federation (Sechenov University)
Published: June 2022

The health status of the population as an integral indicator is a part of the socially-oriented policy of the state, which reflects the degree of its social development and the state of ensuring the quality of public health. It is determined that the current demographic situation in Russia is accompanied by a rapid deterioration in the health of the population and reduction in the number of people of working age for the reason of premature mortality which inevitably causes a decline in human capital. Losses significantly affect the economic, social and intellectual potential of the country. High cost of medical services, dissatisfaction with the quality and limited access to medical care do not meet the interests of the state, patients, and medical service providers. In this regard, the purpose of our paper is to analyze the impact of bronchospasm in children as a peculiar disease that requires medical treatment and otherwise influences future population health and social and economic indicators on the country’s economy and to study the impact of this widespread diseases on the overall economic and socio-economic situation in the country taking into account comparison and indicators from different countries of the world. It has been concluded that to achieve set health goals in public health and reduce negative health impact, international and national public and private partnerships should be promoted.
Program Development for Choosing a Surgical Treatment Option and Mathematical Prediction of Findings in Patients with Postoperative Median Abdominal Hernias
Authors: Arapov D , Cherednikov E , Skorobogatov S , Polubkova G , Belozertsev A , Gladkich T , Korobova L , Borodina E , Chikunov S , Kuritsyn V
Published: June 2022

Background: The aim of the study was to develop a mobile program for choosing a method of surgical treatment and mathematical prediction of findings in patients with postoperative median abdominal hernias, sized small to large, using a complex of non-linear mathematical models to help a practicing surgeon. Methods and Results: There has been detected a non-linear dependence of the parameters of the degree of fatigue and the total electrical activity of the abdominal muscles six months after surgery, based on their preoperative values compared to SpO2 values on the preoperative day and on the postoperative Day 7, and compared to SpO2 values under physical simulation of hernia repair and the selected treatment option. Conclusion: A mobile program has been developed for smartphones that implements the recommended choice of hernioplasty technique and predicts typical features of the patient’s postoperative condition.
Possible Unexplored Aspects of Covid-19 Pathogenesis: The Role of Carboxypeptidase A3
Authors: Budnevsky Andrey V , Ovsyannikov Evgeniy S , Shishkina Victoria V , Esaulenko Dmitry I , Shumilovich Bogdan R , Savushkina Inessa A , Alekseeva Nadezhda G
Published: June 2022

Background: Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). First reported in 2019, it has already caused more than 500 million cases worldwide. The problem of COVID-19 treatment is still relevant, and it is necessary to study in detail the pathogenesis of COVID-19, including the involvement of different immune cells and their mediators. There is increasing evidence of the important role of mast cells (MCs) and their specific protease carboxypeptidase A3 (CPA3) in the pathogenesis of COVID-19. MCs chymase and tryptase are already well studied, while CPA3 is of growing interest. The aim of this review is to study the CPA3 features and mechanisms of its participation in the pathogenesis of COVID-19 and some other infectious and non-infectious diseases. Methods and Results: A literature search was carried out using Scopus, Web of Science, PubMed, Medline, and E-Library databases. Of the158 articles analyzed, 33 were included in the review. CPA3, expressed by MCs in various organs, including human lungs, plays a role in the pathogenesis of COVID-19 by indirectly causing pulmonary fibrosis, associating with levels of inflammatory cytokines and chemokines, and severity of COVID-19.
Computer Assisted Diagnosis of Bipolar Disorder Using Invariant Features
Authors: Jiji Wiselin , A Muthuraj
Published: June 2022

In the study, a supervised learning framework is focussed to identify the bipolar disorder (BD) using structural magnetic resonance imaging is focussed. The work is based on the newly developed 3D SIFT and 3D SURF feature vectors with pattern recognition technique.The overall hypothesis is to deduct BD results from dysfunctional cellular metabolism within specific brain systems (i.e., anterior limbic brain network) as reflected in abnormalities in brain activation patterns and in specific neurochemical measures. The proposed method is used to integrate neuroimaging in exploring the biomarkers of bipolar disorder to reveal the mechanism. In the method, two newly developed feature vectors and kernel PCA are combined or connected to project the feature vectors. Diagnosis process is done by Random Forest. The results reveal that the method has high potential to identify the BD than earlier works, and an average accuracy of 77.77% is reached. This research reveals that neuroimaging studies will help to differentiate bipolar disorder from healthy controls.
Soil Erosion and Sediment Yield Estimation in Ravine Affected Area with Integration of Geospatial Techniques and Revised Universal Soil Loss Equation
Authors: Pani Padmini , Routh Robi , Mohapatra Surya Narayan
Published: June 2022

A considerable amount of plant supportive top soil removal due to water erosion is a major concern for the agricultural dependent countries. The district Morena is one such regions, where top soil is a growing concern for centuries. A huge quantity of soil loss in the region experiences every monsoon season. Quantifying soil loss is a challenging due to its severely dissected topography. The objective of this study is to estimate and map the mean annual soil loss as well as sediment yield for different years in most severely soil erosion affected district of Morena in Madhya Pradesh, India. The Revised Universal Soil Loss Equation and Sediment Delivery Ratio with Integration of Geospatial Techniques have been applied using various open sources data to address the objectives. It has been found that soil erosion has been varied in 1985, 2005 and 2014 respectively. In the year 2005 the soil loss has been reduced compared to 1985, which has been higher again in 2014 (0–66.00 tons/hectors/year in 2005 increased to 0–67.10 tons/hectors/year in 2014), especially when the total wasteland have been reduced substantially, as wastelands are the major contributing area of jungle in the district. The area seems to be going through active erosional process which is subsided by the anthropogenic process in a form of ravine land levelling. The ravine levelled lands are prone to further soil loss in a long run. Therefore, proper management practice needs to be introduced to prevent further soil loss.
Sex under the influence of psychoactive substances among young people in informal settlements in Kampala, Uganda: prevalence, predictors, and implications for sexual and reproductive health programming
Authors: Ssekamatte Tonny , Nalugya Aisha , Mugambe Richard K. , Wagaba Brenda , Nakalembe Doreen , Mutebi Aloysious , Bagonza Richard Asaba , Tigaiza Arnold , Kansiime Winnie K. , Ssempala Richard , Wafula Solomon T. , Isunju John Bosco , Buregyeya Esther
Published: June 2022

Background
Psychoactive substance use has an impact on risky sexual behaviour. Globaly, over 275 million people use psychoactive substances, however evidence on the predictors of sex under the influence of these substatnces is scanty. We investigated the prevalence and predictors of sex under the influence of psychoactive substances among young people aged 18–24 years.
Methods
A cross-sectional study was conducted among 744 sexually active young psychoactive substance users living in informal settlements in Kampala, Uganda. Data were collected through face-to-face interviews using a digitalized structured questionnaire preloaded on Kobocollect. The questionnaire captured data on the socio-demographic characteristics of the respondents, history of psychoactive substance use, and sexual behaviours. Data were analysed using STATA Version 14.0. A modified Poisson regression model was used to determine the factors associated with the outcome variable. Adjusted prevalence ratios at a p-value value ≤ 0.05 with a 95% confidence interval were considered.
Results
About 61.0% (454/744) of the respondents had sex under the influence of psychoactive substances in the last 30 days. The predictors of sex under the influence of psychoactive substances were being female (PR 1.18, 95% CI: 1.04–1.34), being 20–24 years of age (PR: 1.22, 95% CI: 1.04–1.44), being married (PR 1.15, 95% CI: 1.01–1.31) or divorced/separated (PR 1.43, 95% CI: 1.26–1.61), not living with biological parents or guardians (PR 1.22, 95% CI: 0.99–1.50), earning 71 USD and below (PR 0.86, 95% CI: 0.79–1.03) and using alcohol (PR 1.43, 95% CI: 1.25–1.69), marijuana (PR 1.16, 95% CI: 1.02–1.31) and khat (PR 1.25, 95% CI: 1.10–1.42) in the last 30 days.
Conclusion
This study revealed a high prevalence of sex under the influence of psychoactive substances among young people in informal settlements in Kampala, Uganda. The predictors of sex under the influence of psychoactive substances were being female, being 20–24 years of age, being married or divorced/separated, not living with biological parents or guardians, and using alcohol, marijuana and khat in the last 30 days. There is a need for sexual and reproductive health programs to incorporate risk reduction interventions that aim to reduce sex under the influence of psychoactive substances among the said categories in informal settlements.
Direct Comparison Two Fixed-ratio Combination Glucagon-like Peptide Receptor Agonist and Basal Insulin on Glycemic and Non Glycemic Parameters in Type 2 Diabetes
Authors: Risovic Ivona , Dumanovic Mirjana Sumarac , Bojic Mirjana , Djekic Danijel
Published: June 2022

Background.
Two types of fixed-ratio combinations of basal insulin and a glucagon-like protein-1 receptor agonist (GLP-1RA) have been approved for use in type 2 diabetes. One is insulin degludec/liraglutide(iDergLira), and the other is insulin glargine/lixisenatide (iGlarLixi). Direct comparisons between these two combination is not available.
Methods.
The retrospective study included 186 patients with type 2 DM with inadequate glycemic control on metformin and basal insulin (degludec, glargin 100, glargin 300) who were switched fixed-ratio combination GLP-1 RA and basal insulin.Patients were divided into two groups based on the basal insulin before study: group I ( n = 86) treated with degludec were switched to iDegLira and patients group II ( n = 99), 48 treated with glargin were switched to iGlarLixi. The aim of this study was to direct compare the effect between two fixed – ratio combination on glycemic parameters and non glycemic parameters. Follow up was 6 months.
Results
. Mean HbA1c decreased similarly (-1.2% vs.-1.1%). Higher percentage patients in iDegLira group had reached the HbA1c < 7% after 6 months ( 22% vs. 18.2%, p < 0.05). The mean change in FPG was comparable for the two groups, while mean decrease PPG level were lower in iGlarLixi group (2 vs 1.8 mmol/l, p > 0.05). Change in body weight were significant difference in iDegLira group (1.8 kg vs. 0.7 kg, p < 0.001). At the end of the study patients showed decreased in total cholesterol and LDL for 0.2 mmol/L in iDegLira, 0.1 mmol/l in iGlarLixi, triglycerids for 0.3 mmol/l in both groups, increase HDL for 0.1 mm/l in iGlarLixi.
Conclusion
. Our results showed that more patients with iDegLira had HbA1c less than 7% and these combination had better effect on weight loss. There were no difference on FPG and PPG, lipid profile and rate of hypoglycemia.
Stress Memory and Its Regulation in Plants: An Alternative to Breeding for Tolerance
Authors: Kambona Carolyn Mukiri , Koua Patrice Ahossi , Léon Jens , Ballvora Agim
Published: June 2022

Developing stress tolerant plants continues to be the goal of breeders due to their realized yields and stability. Plant responses to drought in particular have been studied in many different plant species, but the occurrence of stress memory as well as the potential mechanisms for memory regulation are not yet well described. It has been observed that plants hold on to past events in a way that adjusts their response to new challenges without altering their genetic constitution. This particular ability could enable training of plants to face future challenges that increase in frequency and intensity in changing climates. A better understanding of stress memory and the associated mechanisms is required to breed stress tolerant genotypes. Contrary to the use of genetic modification tools that has brought controversial hype, misinformation and fear among consumers, epigenetic technology is a powerful tool capable of offering potential benefits. In this perspective, this review discusses different stress memory types and gives an overall view using general examples. Further, focusing on drought stress, we demonstrate coordinated changes in epigenetic and molecular gene expression control mechanisms, the associated transcription memory responses at the genome level and integrated biochemical and physiological responses at cellular level following recurrent drought stress exposures. Indeed, coordinated epigenetic and molecular alterations of expression of specific gene networks link to biochemical and physiological responses that facilitate acclimation and survival of an individual plant during repeated stress.
Key words: plants stressors, drought tolerance, intergenerational and transgenerational memory, epigenetic modification, gene expression.
Dual Energy CT Imaging of Atherosclerotic Plaque using Novel Ultrasmall Superparamagnetic Iron Oxide in Hyperlipidemic Rabbits
Authors: Sato Hideyuki , Fujimoto Shinichiro , Kawaguchi Yuko O. , Nozaki Yui O. , Tomizawa Nobuo , Kudo Ayako , Takahashi Daigo , Kumamaru Kanako , Kogure Yosuke , Aoki Shigeki , Minamino Tohru
Published: June 2022

Purpose
The purpose of this study was to examine whether the use of dual energy CT (DECT) facilitated the visualization of carboxymethyl-diethylaminoethyl dextran magnetite ultra-small superparamagnetic iron oxide (CMEADM-U) accumulation in arteriosclerotic lesions using hyperlipidemic rabbits.
Methods
CMEADM-U was administered to Watanabe hereditary atherosclerotic (WHHL) rabbits (n = 6, 24 sections) and New Zealand white (NZW) rabbits(n = 2, 6 sections). After 72 hours, DECT was performed to prepare virtual monochromatic images (VMI: 35keV, 70keV) and iron-based map. Subsequently, the aorta was collected, and hematoxylin & eosin staining, berlin blue staining, and RAM11 immunostaining.
Results
In the WHHL rabbits, CMEADM-U accumulation was not observed at 70 keV. However, CMEADM-U accumulation consistent with an arteriosclerotic lesion was observed at 35 keV and the iron-based map. On the other hand, in the NZW rabbits, there was no CMEADM-U accumulation in any images. Further, there were significant differences in the iron-based map value at the site of accumulation among the grades of expression on berlin blue staining and RAM11 immunostaining. In addition, there was a good correlation at 35kev and iron-based map value (r = 0.42, p < 0.05).
Conclusion
DECT imaging for CMEADM-U facilitated the assessment of macrophage accumulation in atherosclerotic lesions using a rabbit model of induced aortic atherosclerosis.