bluuebunny/crossref_metadata_2025 huggingface dataset:
Y a-t-il, en-Principe, une autre médiation que celle de l’Archi-Fils ? Réponses sur la « deuxième naissance » de la phénoménologie matérielle.
Authors: Podar Ovidiu-Sorin
Published: April 2021

Cette étude sur la conception henryenne du christianisme prend pour angle d’approche une étude attentive des enjeux philosophiques et anthropologiques de la christologie de M. Henry, singulièrement sur le plan des fondements de la subjectivité absolue. Tout son travail consiste à faire la différence entre un « christianisme transcendantal » et un « christianisme métaphysiquement moniste », pour mettre en évidence la part de l’histoire et celle du transcendantal, mais aussi celle de la culture et celle du point de vue ontologiquement phénoménologique. Ovidiu-Sorin Podar montre aussi que cette portée de la phénoménologie est inaugurée très originairement dans le projet henryen, même si elle s’accomplit phénoménologiquement dans le triptyque final. Cette enquête autour du cogito chrétien, difficile par la technicité du langage utilisé, est utile sur le plan de la compréhension de la progression de l’œuvre henryenne.
La Praxis Michel Henry
Authors: Gibert Mathias
Published: April 2021

Cette étude tente d’analyser la place que tient l’action dans une phénoménologie de la vie. L’auteur montre comment Maine de Biran et Marx sont relus (et parfois modifiés dans leur trajectoire herméneutique) au prisme d’une phénoménologie de l’immanence radicale et d’une théorie ontologique de la passivité, en insistant sur les rapports entre corps originaire et corps organique, eux-mêmes relus dans le cadre historique des « philosophies spiritualistes ». Si M. Henry insiste sur le rôle des pouvoirs dans la compréhension de la corporéité, c’est parce que celle-ci est perçue comme un « pathos immédiat qui détermine notre corps de fond en comble avant qu’il se lève vers le monde ». L’auteur de cette étude pense voir ici une « dé-mondanéisation » de l’ego et sans doute un processus de subjectivisation radicale, au point qu’il souhaite ouvrir un dialogue avec ce qu’il nomme un point de vue matérialiste ou, à tout le moins, les besoins dits « matériels ».
Michel Henry et l’affectivité comme fondement de la psychè
Authors: Alvarado Cabellos Angel
Published: April 2021

Cette étude met en confrontation Michel Henry avec Paul Ricoeur sur la question de la lecture de S. Freud. Il y est donc question de la psyché et de l’affectivité. L’auteur de l’étude rappelle combien le projet de la rationalité contemporaine conjoint des thèses philosophiques sur le statut du sujet et sur celui des schèmes perceptifs de la conscience, au gré d’une relation complexe entre l’étant et le phénomène. L’auteur rappelle les analyses husserliennes relatives à la psyché entendue comme « vie » et ses effets de co-implication. Chez M. Henry, l’inconscient est toutefois compris, soit comme un « inconscient de la représentation », mais cela dans une perspective critique, soit comme cet autre nom de la « vie », spécifiquement dans ses structures d’auto-révélation et d’auto-affectivité. En reprenant la nature du débat entre M. Henry et P. Ricoeur, l’auteur montre que tout l’enjeu réside dans la place que l’on confère aux effets et opérations de la dialectique et de la réflexivité.
De l’affect de la loi au commandement de la Vie
Authors: Hattori Yukihiro
Published: April 2021

Dans le cadre des recherches sur les sources allemandes de la pensée de M. Henry, Yukihiro Hattori livre une étude tentant d’analyser la place que tient le concept d’action dans une phénoménologie de la vie. Pour ce faire l’auteur examine notamment l’analyse par M. Henry de la conception kantienne du respect dans L’essence de la manifestation, ainsi que ses prolongements selon l’analyse du « commandement de la Vie » dans C’est moi la vérité.
Michel Henry et l’humanisme marxien
Authors: Haber Stéphane
Published: April 2021

S. Haber tente de montrer combien le projet de relire l’œuvre de Marx au prisme d’une réévaluation philosophique, en elle-même justifiée et féconde, des descriptions « phénoménologiques » de la souffrance sociale, le conduit non seulement à entériner, même s’il en inverse la téléologie, l’idée althussérienne d’une coupure épistémologique dans l’œuvre de Marx, mais aussi à interpréter différemment, pour cette raison même, les deux « moments » de la pensée marxienne et ce qui caractérise la transition de l’un a l’autre : Les manuscrits de 1844 d’abord, dont Henry ne retiendrait que ce qu’ils doivent à Hegel, Le Capital ensuite, dont il méconnaitrait au contraire ce qu’il lui doit encore. C’est l’équation posée entre souffrance sociale/aliénation et praxis subjective qui est ici interrogée, sur l’horizon d’une théorie de l’« organisation collective », basée sur les concepts de « socialité » et de « coopération », minimisant du coup l’opérativité forte du concept phénoménologique de chair.
Michel Henry
Authors: François Arnaud
Published: April 2021

Le Marx de Michel Henry est un ouvrage paradoxal – comme en témoigne sa conclusion en manière de coup de force, selon laquelle Marx, au motif que sa philosophie contiendrait une « métaphysique de l’individu », est « l’un des premiers penseurs chrétiens de l’Occident » –, et, à ce titre, il ne peut valoir que par l’éclairage inédit qu’il donne aux textes précis qu’il commente. M. Henry procède ainsi en prêtant à Marx une ontologie de la « vie » subjective et monadique, celle-ci étant elle-même déterminée principalement comme « affectivité », tout en cherchant à mettre en lumière les concepts économiques de Marx à partir de cette notion. C’est le double caractère rigoureux et inédit d’un tel éclairage qu’Arnaud François tente de mettre en évidence.
Présentation
Authors: Jean Gégori
Published: April 2021

Cet article, introductif à la publication des notes préparatoires de Michel Henry sur la subjectivité utilisées pour son ouvrage L’essence de la manifestation, tente d’en dégager le sens et les enjeux, non seulement pour une lecture du texte publié dont elles constituent en quelque sorte la « matière première », mais aussi pour une compréhension de l’œuvre elle-même.
Acessos endodônticos: o que todo endodontista deve saber
Authors: Silva Emmanuel João Nogueira Leal da , Barbosa Ana Flávia Almeida , Attademo Rafael Santos , Lima Carolina Oliveira de , Decurcio Daniel de Almeida , Pereira Leandro Augusto Pinto
Published: April 2021

Introdução: Os acessos endodônticos minimamente invasivos (AEMI) surgiram com o intuito de, por meio da preservação de estrutura dentária, manter a resistência à fratura de dentes tratados endodonticamente. A partir do primeiro estudo, em 2010, vários trabalhos foram desenvolvidos buscando entender qual a influência dos AEMI na resistência à fratura de dentes tratados endodonticamente. No entanto, interferências coronárias causadas pelos AEMI poderiam prejudicar a realização dos procedimentos subsequentes à cavidade de acesso, como a localização, instrumentação, limpeza, descontaminação e obturação dos canais radiculares. Objetivo: Com base nessa premissa, a presente revisão teve como objetivo responder algumas perguntas para que o clínico entenda quais são as principais modalidades de AEMI, os impactos da sua abordagem no tratamento endodôntico e o verdadeiro papel do tratamento endodôntico na perda dos elementos dentários. Resultados: Considerando os dados disponíveis até o presente momento, faltam evidências robustas para apoiar a alegação de que os AEMIs preservem a resistência à fratura dos elementos tratados endodonticamente melhor do que nos dentes acessados de maneira tradicional. Além disso, cavidades de acesso minimamente invasivas podem interferir em outras etapas do tratamento endodôntico, podendo torná-lo imprevisível. Conclusão: Dessa forma, pode-se concluir que há uma falta de evidências que apoiem a utilização de cavidades de acesso minimamente invasivas na prática clínica de rotina e/ou no processo de formação de alunos de graduação e pós-graduação.
Avaliação radiográfica da resposta pulpar e periapical de dentes de cães ao Emdogain® após pulpotomia
Authors: Silva Léa Assed Bezerra , Araujo Lisa Danielly Curcino , Fierro Marcela Martin del Campo , Bonifácio Kleber Cortês , Petille Renato , Paula Silva Francisco Wanderley Garcia
Published: April 2021

Introdução: O derivado da matriz do esmalte (Emdogain®) é um extrato de proteína usado para cicatrização periodontal. Objetivo: O objetivo desse estudo foi avaliar radiograficamente a resposta pulpar e periapical de dentes de cães após pulpotomia e uso do gel derivado da matriz do esmalte (Emdogain®). Métodos: A pulpotomia foi realizada em 30 dentes (60 raízes) de 3 cães, e o tecido pulpar remanescente foi recoberto com os seguintes materiais: Grupos 1 e 4: gel derivado da matriz do esmalte (Emdogain®); Grupos 2 e 5: hidróxido de cálcio; Grupos 3 e 6: óxido de zinco e cimento de eugenol. Após 10 dias (Grupos 1-3) e 75 dias (Grupos 4-6) foram obtidas radiografias periapicais e a avaliação radiográfica foi realizada considerando-se: a integridade da lâmina dura, presença de áreas de rarefação óssea periapi- cal, reabsorção radicular (interna e externa) e formação de ponte de dentina. Resultados: No período de 10 dias, to- dos os espécimes dos Grupos 1-3 apresentaram ausência de rarefação óssea periapical, reabsorção radicular (interna e externa) e formação de ponte dentinária. No período de 75 dias, os Grupos 4-6 não apresentaram formação de ponte dentinária em nenhum espécime. Áreas de rarefação óssea periapical foram observadas em 100% das raízes no Grupo 4, 62,5% das raízes no Grupo 6 e em 25% das raízes nos Grupos 5. Conclusão: O uso do gel derivado da matriz do esmalte (Emdogain®) como material para capeamento após a pulpotomia levou à formação de lesões periapicais e não induziu a deposição de tecido mineralizado.
Avaliação da prevalência de complicações associadas a cirurgias bucais realizadas por alunos de graduação
Authors: De-Souza Dyemes Cartegyano Gomes , Batista Carla Aline Chaves , Elizário Allan Vinícius de Camargos , Folha Nara Linne da Silva , Goulart Douglas Rangel
Published: April 2021

Objetivo: O objetivo do presente trabalho foi avaliar a prevalência de complicações trans- e pós-operatórias de cirurgias bucais realizadas em uma clínica de graduação em Odontologia. Métodos: Foi realizado um estudo retrospectivo com prontuários de pacientes atendidos na clínica odontológica do Centro Universitário Euro-Americano, no período de janeiro de 2011 a abril de 2018. Foram selecionados pacientes que haviam sido submetidos a procedimentos de cirurgia bucal, que apresentavam descrição do procedimento e com acompanhamento mínimo de uma semana. Foram coletados dados sociodemográficos e relacionados ao procedimento cirúrgico realizado. Foi feita uma análise estatística descritiva e comparativa, com auxílio do programa SPSS 18.0. Resultados: Foram analisados 1.300 prontuários, sendo que 319 prontuários preenchiam os critérios de inclusão, com um total de 1.132 dentes extraídos e dois casos de frenectomia. Foi observada a prevalência do sexo feminino (58,3%), a idade média dos pacientes foi de 41,28±14,59 anos, e os homens apresentaram maior idade (p=0,01). A maioria dos pacientes não relatou doença sistêmica (68,6%); sendo a presença de doenças sistêmicas maior nas mulheres (X2 =5,71; p=0,01). A maior parte dos pacientes realizou a extração de um (27,9%), dois (23,8%) ou três dentes (12,5%). Foram identificados três casos de complicações transoperatórias: um paciente apresentou síncope vasovagal, outro apresentou comunicação buco-sinusal e outro, hemorragia transoperatória. Conclusão: O estudo identificou uma baixa prevalência de complicações, que está relacionada à realização de um protocolo de atendimento que inclui anamnese detalhada, aferição dos sinais vitais, seleção de casos com menor complexidade e acompanhamento por profissionais especializados.
Tratamento de fratura panfacial com posterior reconstrução de defeito frontal: relato de caso
Authors: Torres Rafael Saraiva , Albuquerque Gustavo Cavalcanti de , Junior Joel Motta , Martins Valber Barbosa , Oliveira Marcelo Vinicius , Tenório Ingrid Soani Amaral de Couto , Raid Denis Esteves
Published: April 2021

As fraturas panfaciais são aquelas que acometem os três terços da face, e seu tratamento é desafiador. Em muitas situações, os pacientes politraumatizados necessitam de tratamento multidisciplinar, pois apresentam traumas em outras regiões do corpo que impedem o tratamento imediato das fraturas faciais. O traumatismo cranioencefálico decorrente de acidentes automobilísticos leva, muitas vezes, à necessidade de uma abordagem neurocirúrgica. O uso de biomaterais, entre eles as biocerâmicas, devido às suas características, vem crescendo a cada dia como uma opção para reconstrução de defeitos ósseos. O objetivo desse artigo é relatar um caso de tratamento de fratura panfacial com reconstrução, por meio de prótese customizada (biocerâmica) de um defeito em região frontal. O paciente com múltiplas fraturas em face, foi inicialmente submetido a procedimento cirúrgico para tratá-las. Posteriormente, para correção de defeito em região frontal, foi instalada uma prótese customizada. O paciente evoluiu bem, com regressão das queixas e com correção do acentuado defeito supraorbital. Pode-se concluir que as fraturas panfaciais representam um desafio complexo no tratamento de trauma facial. Quando são acompanhadas de defeitos ósseos no crânio, o tratamento usando biomateriais e substâncias que possam imitar as características inerentes ao tecido ósseo autógeno vem se tornando uma opção interessante a ser considerada.
Osteoma osteoide em mandíbula: relato de caso
Authors: Torres Rafael Saraiva , Nascimento Saulo Lobo Chateaubriand do , Tavares Paulo Matheus Honda , Martins Valber Barbosa , Junior Joel Motta , Albuquerque Gustavo Cavalcanti de , Oliveira Marcelo Vinicius
Published: April 2021

O osteoma osteoide é um tumor benigno, caracterizado por um crescimento limitado. É comum principalmente em ossos longos e extremamente raro nos ossos gnáticos. Apresenta-se tipicamente como lesão que causa desconforto, principalmente no período noturno, que pode ser aliviado com uso de AINES. Radiograficamente, é uma lesão radiopaca, delimitada por uma região radiolúcida. Dificilmente supera 20mm de diâmetro. Normalmente, o tratamento de eleição é a remoção cirúrgica, e sua recidiva é muito rara. O objetivo do presente trabalho é relatar um caso de um raro osteoma osteoide em região posterior de mandíbula próximo ao canal mandibular. Radiograficamente, apresentava-se como uma lesão esclerótica, bem delimitada, circundada por um halo radiolúcido. Clinicamente, causava desconforto recorrente à paciente. A remoção cirúrgica foi realizada em ambiente ambulatorial, sob anestesia local. Após a exérese da lesão, a paciente apresentou remissão dos sintomas.
Lipossarcoma bem diferenciado de palato mole: relato de caso e revisão da literatura
Authors: Sousa Julio Claudio , Tiveron Rogerio Costa , Ramos Renato Queiroz , Etchebehere Renata Margarida
Published: April 2021

O lipossarcoma é um tumor maligno mesenquimal originado a partir de células do tecido adiposo. Incide, predominantemente, nas extremidades e retroperitônio, sendo raro na região da cabeça e pescoço, em especial na orofaringe. O presente artigo visa relatar o caso clínico de uma mulher com 27 anos de idade, referindo abaulamento de palato mole há três anos. Os exames de imagem demonstravam tecido de densidade compatível com tecido gorduroso. A lesão foi removida e o exame histopatológico sugeriu lipoma de palato mole. A paciente descontinuou o acompanhamento clínico e houve recidiva da lesão três anos após a exérese. Ela foi novamente submetida a tratamento cirúrgico, e o exame histopatológico revelou lipossarcoma bem diferenciado de palato mole. Desde então, a paciente mantém acompanhamento ambulatorial, sem evidências de recidiva. Pode-se concluir que, embora seja raro na região da cabeça e pescoço, o lipossarcoma deve ser considerado como diagnóstico diferencial de lesões com componente lipomatoso.
Terapia LED de baixa intensidade em paralisia facial: relato de caso
Authors: Silva Marcello de Souza , Nicolau Renata Amadei , Pereira Matheus Augusto , Colombo Carlos Eduardo Dias
Published: April 2021

A paralisia facial periférica (PFP) se caracteriza pela interrupção do estímulo neuronal dos ramos do VII par craniano devido a diversos fatores etiológicos que acometem de forma aguda a informação motora total ou parcial da musculatura facial. A PFP pode estar relacionada a processos infecciosos, traumáticos, neoplásicos, autoimunes, metabólicos e iatrogênicos. O objetivo desse artigo é relatar o caso clínico de um paciente de 41 anos de idade, leucoderma, sexo masculino, portador de PFP, compatível com Síndrome de Ramsay Hunt tipo II. O tratamento foi o farmacológico associado à tera- pia LED de baixa intensidade (640±20nm), aplicada em todo trajeto do nervo facial e seus ramos, por 30 segundos, com densidade de energia de 1,7 J/cm2, energia de 3 J e potência de 100 mW. Após a primeira sessão, houve melhora expressiva no quadro clínico, promovendo aumento do tônus muscular e maior contratura da mímica fa- cial, como franzir a testa, fazer bico, sorrir e fechar completamente o olho. Durante 15 dias, foram realizadas cinco aplicações, resultando na ausência de qualquer sinal ou sintoma referente à paralisia. Concluiu-se que a terapia LED de baixa intensidade foi eficaz no tratamento de PFP, com o protocolo testado.
Valores de referência de parâmetros bioquímicos e hematológicos de Rattus novergicus (Wistar) da Unidade de Produção Animal do Instituto de Pesquisa em Fármacos e Medicamentos da Universidade Federal da Paraíba
Authors: Oliveira Francisco de Assis Silveira de , Ferreira Rafael Carlos , Parentoni Roberta Nunes , Andrade Camyla Caroliny Neves de , Lopes Ana Luíza de Oliveira , Cruz Ana Luísa Graça , Duarte Sâmia Sousa , Silva Daiana Karla Frade , Sousa Valgrícia Matias de , Batista Tatianne Mota , Gomes Isabele Beserra Santos , Sobral Marianna Vieira
Published: April 2021

Animais de diferentes criadouros podem apresentar variações em seus parâmetros fisiológicos. Os objetivos desse trabalho foram determinar o intervalo de valores de referência de parâmetros bioquímicos e hematológicos de ratos e ratas Wistar (Rattus norvegicus) da Unidade de Produção Animal do Instituto de Pesquisa em Fármacos e Medicamentos da Universidade Federal da Paraíba (UPA/IPeFarM/UFPB), bem como comparar os dados encontrados com dados publicados para outras unidades de produção animal nacionais e internacionais. Foram utilizados animais saudáveis (n=40/gênero), com 8 a 12 semanas de idade e peso entre 150 e 300 g. Amostras de sangue total foram obtidas por punção intracardíaca e utilizadas para a quantificação de eritrócitos, leucócitos, plaquetas e dos índices hematimétricos. Foram determinadas as concentrações séricas de glicose, triglicérides, colesterol, proteínas totais, ureia, albumina, creatinina, ácido úrico e a atividade enzimática da aspartato aminotransferase, alanina aminotransferase e fosfatase alcalina. Ao comparar os gêneros, foram observadas diferenças significativas entre todos os parâmetros avaliados. Além disso, foram encontradas discrepâncias entre os valores obtidos (exceto proteínas totais, ácido úrico e hemácias) e resultados de outros criadouros. É necessário, portanto, que cada biotério determine os valores de referência do perfil fisiológico de seus animais, considerando os fatores intrínsecos e extrínsecos na homeostase dos mesmos, a fim de fornecer dados reais para os experimentos de suas instituições.
Regularity and monotonicity for solutions to a continuum model of epitaxial growth with nonlocal elastic effects
Authors: Gao Yuan , Lu Xin Yang , Wang Chong
Published: April 2021

We study the following parabolic nonlocal 4-th order degenerate equation:

u
t

=

-

[

2
⁢
π
⁢
H
⁢

(

u
x

)

+

ln
⁡

(

u

x
⁢
x

+
a

)

+

3
2

⁢

(

u

x
⁢
x

+
a

)

2

]

x
⁢
x

,

u_{t}=-\Bigl{[}2\pi H(u_{x})+\ln(u_{xx}+a)+\frac{3}{2}(u_{xx}+a)^{2}\Bigr{]}_{%
xx},

arising from the epitaxial growth on crystalline materials. Here H denotes the Hilbert transform, and

a
>
0

{a>0}

is a given parameter. By relying on the theory of gradient flows,
we first prove the global existence of a variational inequality solution with a general initial datum.
Furthermore, to obtain a global strong solution, the main difficulty is the singularity of the logarithmic term when

u

x
⁢
x

+
a

{u_{xx}+a}

approaches zero. Thus we show that,
if the initial datum

u
0

{u_{0}}

is such that

(

u
0

)

x
⁢
x

+
a

{(u_{0})_{xx}+a}

is uniformly bounded away from zero,
then such property is preserved for all positive times.
Finally, we will prove several higher regularity results for this global strong solution.
These finer properties provide a rigorous justification for the global-in-time monotone solution to the epitaxial growth model with nonlocal elastic effects on vicinal surface.
Double cover K3 surfaces of Hirzebruch surfaces
Authors: Hayashi Taro
Published: April 2021

General K3 surfaces obtained as double covers of the n-th Hirzebruch surfaces with n = 0, 1, 4 are not double covers of other smooth surfaces. We give a criterion for such a K3 surface to be a double covering of another smooth rational surface based on the branch locus of double covers and fibre spaces of Hirzebruch surfaces.
Shapes of centrally symmetric octahedra with prescribed cone-deficits
Authors: Wang Zili
Published: April 2021

The space of Euclidean cone metrics on centrically symmetric octahedra with fixed cone angles θi < 2π, with total surface area 1, has a natural hyperbolic metric, and is locally isometric to hyperbolic 3-space. The metric completion of the space is isometric to a hyperbolic ideal tetrahedron whose dihedral angles are half the cone-deficits 2π − θi.
Non-Degeneracy of Peak Solutions to the Schrödinger–Newton System
Authors: Guo Qing , Xie Huafei
Published: April 2021

We are concerned with the following Schrödinger–Newton problem:

-

ε
2

⁢
Δ
⁢
u

+

V
⁢

(
x
)

⁢
u

=

1

8
⁢
π
⁢

ε
2

⁢

(

∫

ℝ
3

u
2

⁢

(
ξ
)

|

x
-
ξ

|

⁢

𝑑
ξ

)

⁢
u

,

x
∈

ℝ
3

.

-\varepsilon^{2}\Delta u+V(x)u=\frac{1}{8\pi\varepsilon^{2}}\Bigg{(}\int_{% \mathbb{R}^{3}}\frac{u^{2}(\xi)}{|x-\xi|}\,d\xi\Bigg{)}u,\quad x\in\mathbb{R}^% {3}.

For ε small enough, we prove the non-degeneracy of the positive solution to the above problem, that is, the corresponding linear operator

ℒ
ε

⁢

(
η
)

=

-

ε
2

⁢
Δ
⁢
η
⁢

(
x
)

+

V
⁢

(
x
)

⁢
η
⁢

(
x
)

-

1

8
⁢
π
⁢

ε
2

⁢

(

∫

ℝ
3

u
ε
2

⁢

(
ξ
)

|

x
-
ξ

|

⁢

𝑑
ξ

)

⁢
η
⁢

(
x
)

-

1

4
⁢
π
⁢

ε
2

⁢

(

∫

ℝ
3

u
ε

⁢

(
ξ
)

⁢
η
⁢

(
ξ
)

|

x
-
ξ

|

⁢

𝑑
ξ

)

⁢

u
ε

⁢

(
x
)

\mathcal{L}_{\varepsilon}(\eta)=-\varepsilon^{2}\Delta\eta(x)+V(x)\eta(x)-% \frac{1}{8\pi\varepsilon^{2}}\Bigg{(}\int_{\mathbb{R}^{3}}\frac{u_{\varepsilon% }^{2}(\xi)}{|x-\xi|}\,d\xi\Bigg{)}\eta(x)-\frac{1}{4\pi\varepsilon^{2}}\Bigg{(% }\int_{\mathbb{R}^{3}}\frac{u_{\varepsilon}(\xi)\eta(\xi)}{|x-\xi|}\,d\xi\Bigg% {)}u_{\varepsilon}(x)

is non-degenerate, i.e.,

ℒ
ε

⁢

(

η
ε

)

=
0
⇒

η
ε

=
0

{\mathcal{L}_{\varepsilon}(\eta_{\varepsilon})=0\Rightarrow\eta_{\varepsilon}=0}

for small

ε
>
0

{\varepsilon>0}

. The main tools are the local Pohozaev identities and the blow-up analysis. This may be the first non-degeneracy result on the peak solutions to the Schrödinger–Newton system.
circTLK1 facilitates the proliferation and metastasis of renal cell carcinoma by regulating miR-495-3p/CBL axis
Authors: Lei Xiangli , Yang Meiling , Xiao Zhifang , Zhang Heng , Tan Shuai
Published: April 2021

Renal cell carcinoma (RCC) is a common urological malignancy. Circular RNAs (circRNAs) have been confirmed to play an important regulatory role in various cancers. This study aimed to investigate the role and potential mechanism of circTLK1 (hsa_circ_0004442) in RCC. The levels of circTLK1, Cbl proto-oncogene (CBL), and microRNA-495-3p (miR-495-3p) were detected by quantitative reverse transcription polymerase chain reaction or western blot. Cell proliferation, cycle arrest and apoptosis, migration, and invasion were assessed by colony formation, flow cytometry, scratch, and transwell assays. The levels of E-cadherin and Vimentin were measured by western blot. The targeting relationship between miR-495-3p and miR-495-3p or CBL was verified by dual-luciferase reporter assay. Tumor growthin vivowas evaluated by xenograft assay. The results found that circTLK1 and CBL were up-regulated in RCC tissues and cells. Silencing of circTLK1 or CBL inhibited proliferation and metastasis and accelerated apoptosis in RCC cells. In addition, circTLK1 directly bound to miR-495-3p, and CBL was the target of miR-495-3p. circTLK1 sponged miR-495-3p to increase CBL expression. Moreover, knockdown of circTLK1 suppressed tumor growthin vivo. In conclusion, down-regulation of circTLK1 restrained proliferation and metastasis and promoted apoptosis in RCC cells by modulating miR-495-3p/CBL axis.
On q-analogue of Janowski-type starlike functions with respect to symmetric points
Authors: Khan Muhammad Ghaffar , Ahmad Bakhtiar , Khan Raees , Zubair Muhammad , Salleh Zabidin
Published: April 2021

The main objective of the present paper is to define a class of

q

q

-starlike functions with respect to symmetric points in circular domain. Some interesting results of these functions have been evaluated in this article. The sufficiency criteria in the form of convolutions are evaluated. Furthermore, other geometric properties such as coefficient bounds, distortion theorem, closure theorem and extreme point theorem are also obtained for these newly defined functions.
Compact ultra-wideband monopole antenna with tunable notch bandwidth/frequency ratio
Authors: Srivastava Karunesh , Varshney Gaurav , Singh Rajeev
Published: April 2021

A compact tunable notch band ultra-wideband (UWB) antenna is implemented. The band notch characteristics have been obtained by placing a square-shaped metallic loop in the upper ground plane connected via PIN diode. The obtained notched frequency bandwidth can be altered by changing the states of the PIN diode. UWB response with narrow-band notch operation is observed when PIN diode is in ON state. When the PIN diode is in OFF state, the bandwidth of the obtained band notch widens by suppressing the first higher-order resonance and thus a narrow dual-band response is obtained. Moreover, the ratio of the frequency of first higher-order to the fundamental mode in the pass-band can be tuned with the different values as 1.584 and 2.20 in the ON and OFF state of the PIN diode, respectively. Furthermore, the antenna structure offers a compact geometry for the operation with the UWB response with band notch characteristics.
A multi-task approach to argument frame classification at variable granularity levels
Authors: Heinisch Philipp , Cimiano Philipp
Published: April 2021

Within the field of argument mining, an important task consists in predicting the frame of an argument, that is, making explicit the aspects of a controversial discussion that the argument emphasizes and which narrative it constructs. Many approaches so far have adopted the framing classification proposed by Boydstun et al. [3], consisting of 15 categories that have been mainly designed to capture frames in media coverage of political articles. In addition to being quite coarse-grained, these categories are limited in terms of their coverage of the breadth of discussion topics that people debate. Other approaches have proposed to rely on issue-specific and subjective (argumentation) frames indicated by users via labels in debating portals. These labels are overly specific and do often not generalize across topics. We present an approach to bridge between coarse-grained and issue-specific inventories for classifying argumentation frames and propose a supervised approach to classifying frames of arguments at a variable level of granularity by clustering issue-specific, user-provided labels into frame clusters and predicting the frame cluster that an argument evokes. We demonstrate how the approach supports the prediction of frames for varying numbers of clusters. We combine the two tasks, frame prediction with respect to media frames categories as well as prediction of clusters of user-provided labels, in a multi-task setting, learning a classifier that performs the two tasks. As main result, we show that this multi-task setting improves the classification on the single tasks, the media frames classification by up to +9.9 % accuracy and the cluster prediction by up to +8 % accuracy.
Determination of organic pollutants in meconium and its relationship with fetal growth. Case control study in Northwestern Spain
Authors: Álvarez-Silvares Esther , Rubio-Cid Paula , González-Gómez Xiana , Domínguez-Vigo Paula , Fernández-Cruz Tania , Seoane-Pillado Teresa , Martínez-Carballo Elena
Published: April 2021

Objectives

Antenatal exposure to organic pollutants is a leading public health problem. Meconium is a unique matrix to perform prenatal studies because it enables us to retrospectively evaluate fetal exposure accumulated during the second and third trimester. The aim of the present study was to evaluate associations between organic pollutant levels in meconium and birth weight in NW Spain.

Methods

In this study, we quantify the concentrations of 50 organic pollutants together with the total values of the most important chemical groups in meconium using gas chromatography coupled to tandem mass spectrometry.

Results

Organochlorine pesticides, polychlorinated biphenyls and polybrominated diphenyl ethers were detected with the highest levels in meconium from small for gestational age newborns. It was estimated that several congeners were statistically significant (p<0.05). However, organophosphorus pesticides attained higher concentrations in newborns with an appropriate weight.

Conclusions

The occurrence of transplacental transfer can be confirmed. Prenatal exposure to organic pollutants was associated with a decrease in birth weight and, therefore, organic pollutants could have an impact on fetal growth. Nevertheless, these results need validation in larger sample sized studies.
Ernst Cassirer’s Posthumous Grandchildren and the Paradigm Shift of Davos
Authors: Rudolph Enno
Published: April 2021

Scholars who are members of a generation descending from a founder of a philosophical school might be titled as “children.” Those members are characterized as scholars who continue the doctrines of the founder into the future. In the history of ideas there are many examples for such scholarly lineages. Ernst Cassirer’s philosophy was less suitable for generating a successorship in the sense of a filiation: That became dramatically obvious at the famous debate between Martin Heidegger and himself in Davos. Heidegger seemed to be the philosopher of the future by developing a “new essentialism” which shall be expounded as the core-message of his doctrine; this is elaborated in the first chapter of this essay. Only in the post-war generations and long time after Cassirer’s death, eminent scholars working in different scientific disciplines and in different countries based their public research – more or less explicitly – on Cassirer’s philosophy of culture. The second section will discuss three famous examples: Nelson Goodman’s Semiology, Pierre Bourdieu’s Sociology of Symbolic Forms and lastly the Political Philosophy of Jürgen Habermas.
Cellular stress responses of long-lived and cancer-resistant naked mole-rats
Authors: Bozaykut Perinur
Published: April 2021

Objectives

Some organisms are long-lived and naturally resistant to cancer such as naked mole-rats (NMRs). Studies have shown that these animals can better tolerate stress due to mechanisms, such as upregulation of antioxidant pathways and improved proteostasis. In the present study, we aimed to analyze the tolerance against stress and the cellular mechanisms related to the stress response in NMR cells comparative to mouse cells.

Materials and methods

NMR and mouse fibroblasts were exposed to cellular stresses including H2O2 and/or NaNO3 and the viability of the cells were analyzed. In addition messanger RNA (mRNA) expression of antioxidant transcription factor Nuclear factor erythroid-derived 2-like 2 (Nrf2) and its target gene NAD(P)H quinone dehydrogenase 1 (NQO1) were determined by qRT-PCR and comprehensive analysis of stress-related gene expression was performed by RNA-Sequencing in fibroblasts and induced pluripotent stem cells (iPSC).

Results

Surprisingly, NMR fibroblasts were found to be more sensitive than mouse cells to H2O2 and NaNO3. Furthermore, it was shown that fibroblasts and iPSCs mainly aren’t identical in the expression pattern of cellular defense signaling and several factors are mainly downregulated in NMR iPSCs.

Conclusions

Collectively, the data gained from the present study help to improve the understanding of evolved mechanisms that contribute to stress resistance, aging and cancer.
Developmental Role of Adenosine Kinase in the Cerebellum
Authors: Gebril Hoda , Wahba Amir , Zhou Xiaofeng , Lai Tho , Alharfoush Enmar , DiCicco-Bloom Emanuel , Boison Detlev
Published: April 2021

Adenosine acts as a neuromodulator and metabolic regulator of the brain through receptor dependent and independent mechanisms. In the brain, adenosine is tightly controlled through its metabolic enzyme adenosine kinase (ADK), which exists in a cytoplasmic (ADK-S) and nuclear (ADK-L) isoform. We recently discovered that ADK-L contributes to adult hippocampal neurogenesis regulation. Although the cerebellum (CB) is a highly plastic brain area with a delayed developmental trajectory, little is known about the role of ADK. Here, we investigated the developmental profile of ADK expression in C57BL/6 mice CB and assessed its role in developmental and proliferative processes. We found high levels of ADK-L during cerebellar development, which was maintained into adulthood. This pattern contrasts with that of the cerebrum, in which ADK-L expression is gradually downregulated postnatally and largely restricted to astrocytes in adulthood. Supporting a functional role in cell proliferation, we found that the ADK inhibitor 5-iodotubericine (5-ITU) reduced DNA synthesis of granular neuron precursors in a concentration-dependent mannerin vitro. In the developing CB, immunohistochemical studies indicated ADK-L is expressed in immature Purkinje cells and granular neuron precursors, whereas in adulthood, ADK is absent from Purkinje cells, but widely expressed in mature granule neurons and their molecular layer (ML) processes. Furthermore, ADK-L is expressed in developing and mature Bergmann glia in the Purkinje cell layer, and in astrocytes in major cerebellar cortical layers. Together, our data demonstrate an association between neuronal ADK expression and developmental processes of the CB, which supports a functional role of ADK-L in the plasticity of the CB.
Visual Neuroscience Methods for Marmosets: Efficient Receptive Field Mapping and Head-Free Eye Tracking
Authors: Jendritza Patrick , Klein Frederike J. , Rohenkohl Gustavo , Fries Pascal
Published: April 2021

The marmoset has emerged as a promising primate model system, in particular for visual neuroscience. Many common experimental paradigms rely on head fixation and an extended period of eye fixation during the presentation of salient visual stimuli. Both of these behavioral requirements can be challenging for marmosets. Here, we present two methodological developments, each addressing one of these difficulties. First, we show that it is possible to use a standard eye-tracking system without head fixation to assess visual behavior in the marmoset. Eye-tracking quality from head-free animals is sufficient to obtain precise psychometric functions from a visual acuity task. Second, we introduce a novel method for efficient receptive field (RF) mapping that does not rely on moving stimuli but uses fast flashing annuli and wedges. We present data recorded during head-fixation in areas V1 and V6 and show that RF locations are readily obtained within a short period of recording time. Thus, the methodological advancements presented in this work will contribute to establish the marmoset as a valuable model in neuroscience.
Die Haftung der Abschlussprüfer börsennotierter Gesellschaften für Anlegerschäden vor und nach dem FISG
Authors: Poelzig Dörte
Published: April 2021

Der Fall Wirecard wirft eine Vielzahl unterschiedlicher rechtlicher Fragen auf. Hierzu gehört auch die Frage, ob und inwieweit Abschlussprüfer für Anlegerschäden durch Bilanzmanipulationen einstehen müssen, sofern sie ihre Pflichten bei der Pflichtprüfung verletzt haben. Der folgende Beitrag stellt zunächst dar, welche Rolle Abschlussprüfer börsennotierter Gesellschaften am Kapitalmarkt übernehmen. Sodann wird die Haftung der Abschlussprüfer gegenüber der Gesellschaft und gegenüber den geschädigten Anlegern beleuchtet. Abschließend wird untersucht, welche Änderungen mit dem im Entwurfsstadium befindlichen Gesetz zur Stärkung der Finanzmarktintegrität (FISG) für die Abschlussprüferhaftung am Kapitalmarkt verbunden sind.
Das Fondsstandortgesetz im Kontext des europäischen Wettbewerbs der Fondsstandorte
Authors: Wallach Edgar
Published: April 2021

Mit dem Entwurf eines „Gesetzes zur Stärkung des Fondsstandorts Deutschland und zur Umsetzung der Richtlinie (EU) 2019/1160 zur Änderung der Richtlinien 2009/65/EG und 2011/61/EG im Hinblick auf den grenzüberschreitenden Vertrieb von Organismen für gemeinsame Anlagen“ vom 12. 1. 2021 verfolgt die Bundesregierung die Ziele, Wettbewerbsnachteile des deutschen Fondsstandorts im Vergleich zu anderen europäischen Fondsstandorten auszugleichen, das Innovations- und Wachstumspotenzial der deutschen Wirtschaft, insbesondere im Bereich der Startups, durch Steuererleichterungen zu steigern und die Richtlinie (EU) 2019/1160 zur weiteren Harmonisierung des grenzüberschreitenden Vertriebs von Investmentfonds in deutsches Rechts umzusetzen. Der vorliegende Beitrag stellt die wesentlichen Inhalte des Regierungsentwurfs dar, ordnet ihn in die bisherigen Bemühungen des Gesetzgebers um den deutschen Fondsstandort ein, bewertet ihn vor dem Hintergrund des globalen Wettbewerbs der Fondsstandorte und zeigt weiteren Handlungsbedarf auf.
IFR, IFD und WpIG – Neuer Rechtsrahmen für Wertpapierfirmen
Authors: Schuster Gunnar , Nemeczek Heinrich
Published: April 2021

Der folgende Beitrag setzt den ersten Teil, der in ZBB 2021, 35 erschienen ist, fort und behandelt die neuen Kapital- und Liquiditätsanforderungen an Wertpapierfirmen, die Aufsichtsanforderungen an Konzentrationsrisiken, die Änderungen bei der aufsichtlichen Konsolidierung sowie die Vorgaben zur internen Unternehmensführung und zur Vergütung.
Community engagement in Canadian health and social science research: Field reports on four studies
Authors: Eaton Andrew
Published: April 2021

Community engagement is a hallmark of Canadian health and social science research, yet we lack detailed descriptions of pragmatic peer engagement possibilities. People personally affected by a study’s topic can actively contribute to design, data collection, intervention delivery, analysis, and dissemination yet the nature and scope of involvement can vary based on context. The shift from academic to community-based research teams, where peers who share participant identities assume a leadership role, may be attributed to the HIV/AIDS response where community co-production of knowledge has been a fundamental component since the epidemic’s onset. This article discusses four health and social science studies from a community-based participatory research (CBPR) framework and synthesizes the strengths and limitations of community engagement across these endeavours to offer lessons learned that may inform the design of future CBPR projects.
Synergies in subject parallels: Coteaching “music-drama”
Authors: Zimmerman Nilsson Marie-Helene , Murphy Colette
Published: April 2021

This case study contributes with a new coteaching design, in which experienced teachers from two different aesthetic subjects are planning, teaching and evaluating together in higher education, more specifically in general preschool teacher education. The aim of the study is to analyse how two drama teachers and a music teacher reflect on their coteaching. Coteaching, when teachers teach together with shared responsibility to meet their students’ learning needs, is a pedagogical approach to enable an active learning process. Research and practice in coteaching have emerged, mostly designed with coteachers within the same subject. However, more research is needed about teachers from different subjects coteaching together. The theoretical framework is sociocultural, with special emphasis on aspects of learning from ‘the other’ in praxis by working in a zone of proximal development (ZPD). Analysed data consist of field notes and audio-recorded teacher group conversations. Main findings show synergies in subject parallels, based on the analysis of coteachers’ reflections as learning processes within their ZPD. In conclusion, a major contribution in terms of synergy in coteaching appears in subject parallels related to specific subject matter concepts, where music and drama are intertwined in the classroom as “music-drama”, as a new dimension.
Have Norwegians tried psilocybin, and do they accept it as a medicine?
Authors: Jacobsen Henrik Børsting , Stubhaug Audun , Holmøy Bjørn , Kvam Tor Morten , Reme Silje Endresen
Published: April 2021

Background

Psilocybin is emerging as a promising therapeutic agent for a wide range of psychiatric conditions, and clinical trials on psilocybin-assisted treatment are forthcoming in Scandinavian countries. However, little is known about attitudes towards this psychedelic compound among the general public in Nordic countries. This might represent a confound, and reduce the validity of research findings or the overall feasibility of conducting high-quality clinical trials.

Aims

The main objective of this study is to address the knowledge gap surrounding use and attitudes towards psilocybin in Norway.

Methods

We asked a representative sample of the Norwegian population (N = 1,078) if they have ever tried psilocybin and if they would be willing to do so as part of medical treatment. These questions were part of a larger online survey on a variety personal preferences and attitudes, and the survey was not presented as a study on psilocybin.

Results

Of the 1,078 respondents, 8% reported previous psilocybin use and 51% were willing to try psilocybin in medical treatment.

Conclusions

Psilocybin use is more common in Norway than the authors hypothesized, and the general public is relatively open to using psilocybin in a medical context. The latter is interpreted as promising with regards to the feasibility of conducting rigorous clinical trials on potential effects and side effects of psilocybin-assisted treatment in Norway.
MODIFIED EPOXY COMPOSITION FOR PRODUCTION OF THERMAL PROTECTION COATING
Authors:   Perm National Research Polytechnic University, Maramygin Alexandr
Published: April 2021

The material summed up in this article is recommended for engineers of aerospace industry, as well as can be of inter-est for the production personnel. The article covers the production of “scale-like” outer thermal protection coatings on the basis of syntactic materials with tumescent characteristics used in the production of special purpose equipment. The research per-formed sums up the results of the practical implementation of the technology adaptative method in the conditions of the real outer thermal protection coatings production. This work describes a typical technological process of “scale-like” outer thermal protection coating production from the panels based on syntactic material, including the stages of separate panels production with the help of shape-generating molding tools and forming of thermal protection coating by laying and molding-on of separate panels on the pressure restraint layer of the aircraft. The author proves the effectiveness of technology adaptative method us-age on the example of modification processes of pattern polymer composition being the basis of syntactic material. The re-search describes the solutions for the production cycle optimization via improvement of technological properties of the materials used. The work also contains the results of the researches, including spectral and thermochemical analyses of polymer compo-sitions modified by polyisocyanates, and describes the research techniques of their properties. Quasi-eutectic compositions of aliphatic and aromatic amines are received, which, being used as curative of reactive epoxiurethane polymers produced on the basis of epoxy-diane oligomers and polyisocyanates, enable to divide the polymerization process into two stages. The method described in the article provides the elimination of panel defects on the stage of molding-on due to implementation of mode separation in polymerization processes, which contributes towards the quality and reliability of thermal protection coating.
Laboratory Studies of Carboniferous Reservoirs of High-Viscosity Oil Fields Using Carbondioxide
Authors:   PermNIPIneft branch of LUKOIL-Engineering LLC in Perm, Kalinin Stanislav A. , Morozyuk Oleg A. ,   PermNIPIneft branch of LUKOIL-Engineering LLC in Perm
Published: April 2021

It is of current concern for the Permian-Carboniferous reservior of the Usinskoye field to develop low-permeable matrix blocks of carboniferous reservoirs, which contain major reserves of high-viscosity oil. To increase effectiveness of the currently used thermal oil recovery methods, the authors suggest using carbon dioxide as a reservoir stimulation agent. Due to a high mobility in its supercritical condition, СО2 is, theoretically, able to penetrate matrix blocks, dissolve in oil and, additionally, decrease its viscosity. Thus, СО2 applications together with a heat carrier could increase effectiveness of the high-viscosity oil recoveries and improve production parameters of the Permian-Carboniferous reservior of the Usinskoye field. During carbon dioxide injections, including combinations with various agents, some additional oil production is possible due to certain factors. Determination of the influencing factors and detection of the most critical ones is possible in laboratory tests. So, laboratory studies entail the key stage in justification of the technology effectiveness. The paper deals with describing the laboratory facilities and methodologies based on reviews of the best world practice and previous laboratory researches. These aim at evaluating effectiveness of thermal, gas and combined oil recovery enhancement methods. In particular, the authors explore experimental facilities and propose methodology to perform integrated researches of the combined heat carrier and carbon dioxide injection technology to justify the effective super-viscous oil recovery method.