bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Pharmacological Thromboprophylaxis, Tourniquet and Drainage on Hemorrhagic Complications in the Early Stage after Knee Arthroplasty: Preliminary Results
Authors: Kasimova A. R. , Bozhkova S. A. , Tikhilov R. M. , Saraev A. V. , Petukhov A. I. , Zhuravkov A. A. , Arefyeva A. N.
Published: October 2019

Background — venous thromboembolic complications (VTC) are potential life-threatening complications following knee arthroplasty (KA). An optimal thromboprophylaxis strategy should reduce the risk of developing VTC without increasing the risk of hemorrhagic complications. The purpose of the study is to evaluate the effect of the drugs (acetylsalicylic acid, dabigatran etexilate and rivaroxaban) for the pharmacological thromboprophylaxis and the features of the surgical procedure (use of the tourniquet and drainage) on hemorrhagic complications in early periods after knee arthroplasty. Materials and Methods. 335 patients (65 men and 270 women), without additional risk factors for the development of thromboembolic complications, were included into the study. Those patients were admitted for planned primary / revision knee arthroplasty and corresponded to inclusion / non-inclusion criteria. Patients were randomized into three clinical groups, depending on the drug used thromboprophylaxis. During the inpatient treatment period, all patients recorded the development of symptomatic VTCs and the development of hemorrhagic complications. According to the clinical indications, the number of knee joint punctures was taken into account: patella balloting, restricted flexion and a smooth joint contour. Results. Symptomatic VTCs were not observed during the study period. The volume of intraoperative blood loss did not depend on the drugs used for  thromboprophylaxis, and was determined only by the surgical technique (ρs= -0.615, p = 0.0001). The use of the tourniquet during the procedure significantly reduced intraoperative blood loss (p = 0.023). No relation between surgical technique and anemia on the 5th day (ρs = 0.11, p = 0.05), as well as between surgical technique and total blood loss (ρs = 0.12, p = 0.01) was established; weak reliable correlation between the use of the tourniquet and hidden blood loss (ρs = -0.22, p = 0.01) was reported. A negative average significant correlation was observed (ρs = -0.42, p = 0.01) for the volume of total blood loss and hemoglobin level on the 5th day after the surgery. The number of postoperative punctures was comparable in the study groups. Conclusion. Sample of present size is not sufficient to make conclusions about the equal efficacy of using acetylsalicylic acid, dabigatran and rivaroxaban for thromboprophylaxis after knee arthroplasty in patients without additional risk factors for thrombosis. Data on the significant correlation of the surgical technique with the volume of intraoperative and latent blood loss, as well as total blood loss and hemoglobin level on the 5th day after the operation allow to suggest a possible effect of the drug for thromboprophylaxis on blood loss stargin from 2nd day after the procedure.
Influence of Epidemiologic and Clinical Trends on Risk Stratification and Net Clinical Benefit of Long-term Oral Anticoagulation for Nonvalvular Atrial Fibrillation
Authors: Asinger Richard W. , Shroff Gautam R.
Published: October 2019

The prevalence of atrial fibrillation without rheumatic valvular disease, nonvalvular atrial fibrillation (NVAF), increases with age and independently predicts future stroke and systemic embolism. Randomized controlled trials of long-term oral anticoagulation for NVAF since the 1980s report a 67% risk reduction in stroke and systemic embolism. Data from these trials are used in risk calculators to predict stroke and bleeding; clinicians use these calculators to determine individualized net clinical benefit of oral anticoagulation. Over the past three decades, NVAF stroke rates have declined independent of oral anticoagulation. Newer asymptomatic (subclinical) NVAF populations are being identified, and clinical practice has changed with increasingly older patients (with higher fall and bleeding risk) receiving oral anticoagulation. These trends suggest contemporary patients with NVAF may derive a lower net benefit from oral anticoagulation compared with those in the original randomized controlled trial. Methods that evaluate for and continuously monitor net clinical benefit of oral anticoagulation for contemporary NVAF are necessary.
Genetic Arrhythmia Center: Caring for Patients and Families at Risk for Sudden Cardiac Death and Advancing the Understanding of Rare Cardiomyopathies and Channelopathies
Authors: Kunz Miranda S. , Singh Sajya M. , Casey Susan A. , Storey Katelyn M. , Katsiyiannis William T. , Abdelhadi Raed H. , Berg Allison A. , Bennett Mosi K. , Sengupta Jay D.
Published: October 2019

Although rare in the general population, genetic arrhythmia syndromes have a significant public health impact due to their contribution to the incidence of sudden cardiac death, particularly in children and young adults. When sudden cardiac death occurs in the absence of ischemic heart disease, a genetic cardiac condition may be suspected and clinical and genetic screening of family members is recommended. The Genetic Arrhythmia Center at the Minneapolis Heart Institute collaborates with local partners in the Sudden Cardiac Arrest network to connect patients and their family members with interdisciplinary care for diagnosis and treatment of these conditions. The most common conditions seen in the Genetic Arrhythmia Center include arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction, long QT syndrome, and Brugada syndrome. In addition to providing clinical care and genetic testing and counseling services, the Genetic Arrhythmia Center is working to advance the scientific understanding of the clinical presentation and natural history of these rare conditions.
The Challenges of Including Patients With Aphasia in Qualitative Research for Health Service Redesign: Qualitative Interview Study
Authors: Prior Sarah , Miller Andrea , Campbell Steven , Linegar Karen , Peterson Gregory
Published: October 2019

Background

Aphasia is an impairment of language, affecting the production or comprehension of speech and the ability to read or write. Aphasia is a frequent complication of stroke and is a major disability for patients and their families. The provision of services for stroke patients differs across health care providers and regions, and strategies directed at improving these services have benefited from the involvement of patients. However, patients with aphasia are often excluded from these co-design activities due to a diminished capacity to communicate verbally and a lack of health researcher experience in working with patients with aphasia.

Objective

The primary aim of this paper is to identify approaches appropriate for working with patients with aphasia in an interview situation and, more generally, determine the importance of including people with aphasia in health service improvement research. The secondary aim is to describe the experiences of researchers involved in interviewing patients with aphasia.

Methods

A total of 5 poststroke patients with aphasia participated in face-to-face interviews in their homes to gain insight into their in-hospital experience following their stroke. Interviews were audio-recorded, and thematic analysis was performed. The experiences of the researchers interviewing these patients were informally recorded postinterview, and themes were derived from these reflections.

Results

The interview technique utilized in this study was unsuitable to gain rich, qualitative data from patients with aphasia. The experience of researchers performing these interviews suggests that preparation, emotion, and understanding were three of the main factors influencing their ability to gather useful experiential information from patients with aphasia. Patients with aphasia are valuable contributors to qualitative health services research, and researchers need to be flexible and adaptable in their methods of engagement.

Conclusions

Including patients with aphasia in health service redesign research requires the use of nontraditional interview techniques. Researchers intending to engage patients with aphasia must devise appropriate strategies and methods to maximize the contributions and valuable communications of these participants.
A Mobile App Adopting an Identity Focus to Promote Physical Activity (MoveDaily): Iterative Design Study (Preprint)
Authors: Hooglugt Floris , Ludden Geke D S
Published: October 2019

BACKGROUND

Web-based and mobile interventions to influence physical activity behavior have had limited effects on sustained behavior change. One reason may be that the interventions aim to change largely habitual behavior. Following an identity-oriented approach could be a successful strategy to behavior change because people are committed to behave in line with their self-perception of identity.

OBJECTIVE

In this paper, we take a closer look at the role of motivation in long-term adherence to lifestyle interventions. The paper outlines a method for web-based or mobile intervention development that allows exploration of integrating behavior change theory into the design process. We will describe the development of a mobile app that allows people to be self-determined and to value and self-regulate physical activity by adopting an identity-oriented approach.

METHODS

This paper describes a Research through Design (RtD) process in which design activities are carried out as part of the knowledge-generating process. Two RtD phases were completed, followed by a conceptual design phase. In the first RtD phase, 8 participants used diary cards to study initial attitudes toward starting with small changes in physical activity. In the second RtD phase, 26 participants used a web-based app to study changes in physical activity. We used an adapted version of the Self-Report Habit Index (SRHI) to evaluate individuals’ perceptions of a particular behavior with respect to the three facets of a habit. The conceptual design phase consolidated the results from first two RtD phases into a design of a mobile app that combines an identity approach with gamification principles. The conceptual design was evaluated in a user-experience study with 4 participants.

RESULTS

In the first RtD phase, we found that interacting daily with diary cards and reflecting on physical activity patterns is a promising strategy but works better through a digital medium. In the second RtD phase, SHRI ratings from all participants generally increased each week. In the conceptual design phase, we found that the concept of the mobile app was positively evaluated by participants. However, participants mentioned that terms such as “identity” do not resonate with them and that scenarios could be simpler.

CONCLUSIONS

This paper provides deeper insights into designing for electronic health (eHealth) interventions and services and suggests a new way that motivation can be shaped by the design of an intervention and adherence to physical activity. To the best of our knowledge, this was the first iterative design study in which the effects of adopting an identity approach to both motivation and physical activity were included and observed. Initial promising results were found for using a web-based intervention where habits and identification with the personal importance of a behavior were repetitively triggered.
The Mediating Role of Organizational Reputation and Trust in the Intention to Use Wearable Health Devices: Cross-Country Study (Preprint)
Authors: Adebesin Funmi , Mwalugha Revingstone
Published: October 2019

BACKGROUND

The use of consumer wearable health devices for fitness tracking has seen an upward trend across the globe. Previous studies have shown that trust is an important factor in the adoption and use of new technologies. However, little is known about the influence of organizational reputation and trust on the intention to use wearable health devices.

OBJECTIVE

This study aimed to investigate the mediating role of organizational reputation and trust in the intention to use wearable health devices and to examine the extent to which the country of residence influenced the effect of organizational reputation on consumers’ trust in and intention to use wearable health devices.

METHODS

We conducted a cross-country survey with participants from Kenya and South Africa using a Google Forms questionnaire derived from previously validated items. A series of mediation regression analyses were carried out using the PROCESS macro with the bootstrap CI procedure. A one-way, between-group multivariate analysis of variance (MANOVA) was also used to determine the key factors that distinguish Kenyans and South Africans in their intention to use wearable health devices.

RESULTS

A total of 232 questionnaire responses were collected. The results revealed that organizational reputation significantly mediates the relationship between trust propensity and trust, with an indirect effect of 0.22 (95% CI 0.143-0.309). Organizational reputation also plays a significant direct role in the intention to use a wearable health device, with a direct effect of 0.32 (95% CI 0.175-0.483). This role is regardless of participants’ country of residence. Furthermore, there is a significant mediating effect of trust on the relationship between trust propensity and the intention to use a wearable health device, with an indirect effect of 0.26 (95% CI 0.172-0.349); between perceived security and the intention to use a wearable health device, with an indirect effect of 0.36 (95% CI 0.255-0.461); and between perceived privacy and the intention to use a wearable health device, with an indirect effect of 0.42 (95% CI 0.282-0.557). The MANOVA test shows statistically significant differences in all variables for both groups, with the exception of organizational reputation where there is no significant difference between the two cohorts.

CONCLUSIONS

Organizational reputation has a significant direct influence on participants’ trust in and the intention to use a wearable health device irrespective of their country of residence. Even in the presence of perceived security and perceived privacy, trust has a significant mediating effect on the intention to use a wearable health device.
Ethical, Legal, and Social Issues Related to the Inclusion of Individuals With Intellectual Disabilities in Electronic Health Record Research: Scoping Review (Preprint)
Authors: Raspa Melissa , Moultrie Rebecca , Wagner Laura , Edwards Anne , Andrews Sara , Frisch Mary Katherine , Turner-Brown Lauren , Wheeler Anne
Published: October 2019

BACKGROUND

Data from electronic health records (EHRs) are increasingly used in the field of genetic research to further precision medicine initiatives. However, many of these efforts exclude individuals with intellectual disabilities, which often stem from genetic conditions. To include this important subpopulation in EHR research, important ethical, legal, and social issues should be considered.

OBJECTIVE

The goal of this study was to review prior research to better understand what ethical, legal, and social issues may need further investigation when considering the research use of EHRs for individuals with genetic conditions that may result in intellectual disability. This information will be valuable in developing methods and best practices for involving this group in research given they are considered a vulnerable population that may need special research protections.

METHODS

We conducted a scoping review to examine issues related to the use of EHRs for research purposes and those more broadly associated with genetic research. The initial search yielded a total of 460 unique citations. We used an evaluative coding process to determine relevancy for inclusion.

RESULTS

This approach resulted in 59 articles in the following areas: informed consent, privacy and security, return of results, and vulnerable populations. The review included several models of garnering informed consent in EHR or genetic research, including tiered or categorical, blanket or general, open, and opt-out models. Second, studies reported on patients’ concerns regarding the privacy and security of EHR or genetic data, such as who has access, type of data use in research, identifiability, and risks associated with privacy breach. The literature on return of research results using biospecimens examined the dissension in the field, particularly when sharing individualized genetic results. Finally, work involving vulnerable populations highlighted special considerations when conducting EHR or genetic research.

CONCLUSIONS

The results frame important questions for researchers to consider when designing EHR studies, which include individuals with intellectual disabilities, including appropriate safeguards and protections.
PENGEMBANGAN AGROINDUSTRI GULA KELAPA DI KABUPATEN CILACAP: KAJIAN STRATEGI MARKETING HASIL PERTANIAN
Authors: Pudyastuti Nariswari Novi , Masyhuri Masyhuri , Suryantini Any
Published: October 2019

Coconut sugar industry as a part of agroindustry has given significances in regional agriculture development, however  it has not yet met the businessman needs because of the lack significant industrial development and marketing efficiency. Therefore, this study aims at identifying both the external and internal factors influencing the marketing development and formulating the alternative marketing strategies for coconut sugar products especially in Jeruklegi and Kawunganten Dirstrict of Cilacap Regency. This area is chosen based on certain considerations and this study involves 47 respondents. The methods used in this study are instrument test analysis, descriptive analysis to identify the internal and external factors, and SWOT analysis to formulate the alternative strategies for coconut sugar industry development. The result showes that generally there is still lack of quality of human resources, based on validity and reliability tests there are eight internal and ten externals factors influencing the coconut sugar marketing in Cilacap Regency. The industrial position is in cell IV which means in a stable phase, meanwhile, the main alternative strategy that can be applied in coconut sugar marketing development in Cilacap Regency is quadrant 1 namely the SO (Strengths Opportunities) strategy, it includes optimizing the production capacity, expanding the sale area, and increasing the promotional activities. Other supporting alternative strategies that consist of ST strategies (Strength Threats), WO (Weaknesses Opportunities), and WT (Threats Weaknesses) are increasing the use of production equipment technology, increasing marketing efficiency, increasing the market price knowledge, maintaining product quality, choosing managers to form beneficiary group, cooperating among villages, improving the production cleanliness, looking for funds from cooperatives in other areas for business capital, and establishing the information service center.
Proteomics and Metabolomics in Kidney Disease, including Insights into Etiology, Treatment, and Prevention
Authors: Dubin Ruth F. , Rhee Eugene P.
Published: October 2019

In this review of the application of proteomics and metabolomics to kidney disease research, we review key concepts, highlight illustrative examples, and outline future directions. The proteome and metabolome reflect the influence of environmental exposures in addition to genetic coding. Circulating levels of proteins and metabolites are dynamic and modifiable, and thus amenable to therapeutic targeting. Design and analytic considerations in proteomics and metabolomics studies should be tailored to the investigator’s goals. For the identification of clinical biomarkers, adjustment for all potential confounding variables, particularly GFR, and strict significance thresholds are warranted. However, this approach has the potential to obscure biologic signals and can be overly conservative given the high degree of intercorrelation within the proteome and metabolome. Mass spectrometry, often coupled to up-front chromatographic separation techniques, is a major workhorse in both proteomics and metabolomics. High-throughput antibody- and aptamer-based proteomic platforms have emerged as additional, powerful approaches to assay the proteome. As the breadth of coverage for these methodologies continues to expand, machine learning tools and pathway analyses can help select the molecules of greatest interest and categorize them in distinct biologic themes. Studies to date have already made a substantial effect, for example elucidating target antigens in membranous nephropathy, identifying a signature of urinary peptides that adds prognostic information to urinary albumin in CKD, implicating circulating inflammatory proteins as potential mediators of diabetic nephropathy, demonstrating the key role of the microbiome in the uremic milieu, and highlighting kidney bioenergetics as a modifiable factor in AKI. Additional studies are required to replicate and expand on these findings in independent cohorts. Further, more work is needed to understand the longitudinal trajectory of select protein and metabolite markers, perform transomics analyses within merged datasets, and incorporate more kidney tissue–based investigation.
ANTIOXIDANT ACTIVITY OF HALOPHILA OVALIS AND HALOPHILA BECCARII (HYDROCHARITACEAE): TWO IMPORTANT SEAGRASS SPECIES OF CHILIKA LAGOON, INDIA
Authors: KUMAR KAR SUBRAT , SAHOO SUPRAVA , KAR BASUDEBA , KUMAR NAIK SOUMENDRA , PANDA PRATAP CHANDRA
Published: October 2019

Objective: The present study was undertaken to evaluate the total phenolic and flavonoid content and the antioxidant property of two important seagrass species namely, Halophila ovalis and Halophila beccarii occurring in Chilika lagoon, Odisha, India.

Methods: Total Phenolic Content (TPC) of the extracts of Halophila species was determined by Folin-Ciocalteu method with little modifications and the total flavonoid content (TFC) was measured by aluminum chloride colorimetric assay. The antioxidant activity of different extracts was investigated by DPPH and ABTS radical scavenging activity. IC50 values were calculated for the DPPH and ABTS methods.

Result: The study revealed that the methanol extract of H. ovalis has greater antioxidant activity than H. beccarii. Methanol extract of both the species (H. ovalis and H. beccarii) was found to possess high phenolic content at value of 70.25 mg GAE/g of extract and 48.53 mg GAE/g of extract respectively. Similarly flavonoid contents was found highest in methanol extract for both H. ovalis (76.82 mg quercetin equivalent/ g of extract) and H. beccarii (64.28 mg quercetin equivalent/ g of extract). The antioxidant activity of different extracts of these two species were evaluated using DPPH and ABTS radical assay. The methanol extract of both H. ovalis and H. beccarii showed high radical scavenging activity with IC50 values of 37.77 μg/ml and 52.25 μg/ml for DPPH and 25.62 μg/ml and 45.45 μg/ml for ABTS respectively.

Conclusion: The study revealed the potential of the Halophila species as natural sources of antioxidants having considerable commercial importance.
PHYTOCHEMICAL AND ETHNOPHARMACOLOGICAL REVIEW OF HETEROPYXIS NATALENSIS
Authors: MAROYI ALFRED
Published: October 2019

The bark, leaves, roots, and twigs of Heteropyxis natalensis are widely used as herbal medicines in Southern Africa. The aim of this study was to review the phytochemical and ethnopharmacological properties of H. natalensis so as to provide baseline data required for evaluating the therapeutic potential of the species. Information on the botanical profile, medicinal uses, phytochemistry, and pharmacological properties of H. natalensis was undertaken using databases such as ScienceDirect, SciFinder, PubMed, Google Scholar, Medline, SCOPUS, EThOS, ProQuest, OATD, and open-thesis. Pre-electronic literature of conference papers, scientific articles, books, book chapters, dissertations, and theses were carried out at the university library. Literature search revealed that H. natalensis is used as an aphrodisiac, anti-infection, blood purifier, decongestant, for weaning, ethnoveterinary medicine and as herbal medicine for bleeding disorders, gums, nose, colds, gum infections, impotence, menorrhagia, respiratory disorders, toothache, and wounds. Phytochemical compounds identified from the species include essential oils, 3β-hydroxylup-20(29)-en-28-al, (E)-1-(2’,4’-dihyroxy,5’- methoxy,3’-methylphenyl)-3-phenylprop-2-en-1-one, (2E)-2-[(2E)-1-hydroxy-3-phenylprop-2-en-1-ylidene]-5-methoxy-6,6-dimethylcyclohex-4-ene- 1,3-dione, 2’,4’-dihydroxy-6’-methoxy-3’,5’-dimethylchalcone, 3’,4’,5’-tri-O-methyl-3,4-methylenedioxy ellagic acid, 3,5,7-trihydroxyflavan, 5-hydroxy- 7-methoxy-6-methylflavanone, aurentiacin A, betulinic acid, cardamomin, lupenone, lupeol, quercetin, and sitost-4-en-3-one. Pharmacological studies revealed that H. natalensis extracts and compounds have antibacterial, antimycobacterial, antifungal, antioxidant, anti-inflammatory, cytotoxicity, and pro-inflammatory activities. Detailed studies are required to establish the efficacy, clinical relevance, safety and mechanisms of action of the plant extracts, and compounds of H. natalensis.
IN VITRO CYTOTOXIC ACTIVITY OF RODENT TUBER MUTANT PLANT (TYPHONIUM FLAGELLIFORME LODD.) AGAINST TO MCF-7 BREAST CANCER CELL LINE
Authors: SIANIPAR NESTI FRONIKA , ASSIDQI KHOIRUNNISA , PURNAMANINGSIH RAGAPADMI , HERLINA TATI
Published: October 2019

Objective: The objective of this study was to determine the new bioactive compounds through gas chromatography–mass spectrometry analysis and the cytotoxic activity of two rodent tuber mutant plants against breast cancer cells (MCF-7).

Methods: The bioactive compounds in rodent tuber mutant plants were successfully increased by somaclonal variation using gamma rays irradiation technique. Further, the cytotoxicity activity of rodent tuber mutant plants was tested on breast cancer cell line (MCF-7) performed by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide assay method.

Results: This results study confirmed that the presence of phytochemical composition in the tuber of rodent tuber mutant plants KB 6–1–3–4 and KB 6–9–5 was found six bioactive compounds from fatty acid groups which have the potential as an anticancer compound, such as octadecanoic acid, hexadecanoic acid, hexadecanoic acid methyl ester, 9-octadecanoic acid, linolelaidic acid methyl ester, and butanoic acid. The results showed that extracts from rodent tuber mutant plants had a cytotoxicity effect on MCF-7 cancer cells with half maximal inhibitory concentration (IC50) values that were lower than the control (mother plant). In vitro tests of KB 6–1–3–4 and KB 6–9–5 against MCF-7 cancer cell lines have IC50 values of 12.482 μg/mL and 7.043 μg/mL, respectively, while it had a lower cytotoxicity effect with the IC50 value of control plant was 19.113 μg/mL. The mutant plants of KB 6-9-5 have 3 times more effective than control.

Conclusion: The results of this study clearly indicated that rodent tuber mutant plants have shown promising as an anticancer drug on breast cancer.
STUDYING THE EFFECT OF DIFFERENT GELLING AGENT ON THE PREPARATION AND CHARACTERIZATION OF METRONIDAZOLE AS TOPICAL EMULGEL
Authors: DAOOD NOOR M , E JASSIM ZAINAB , M GAREEB MOWAFAQ , ZEKI HIBA
Published: October 2019

Objective: Emulgels as topical dosage form recently gains an interest represent a combination of gels and emulsions in united form. Metronidazole is an antimicrobial and anti-inflammatory drug, as the first topical therapy approved for rosacea; metronidazole has remained a cornerstone of rosacea management.

Methods: Emulgel formulations of metronidazole benzoate were prepared using two types of gelling agents, Carbopol 940 and hydroxypropyl methylcellulose, the influence of type and concentration of them on the release of metronidazole benzoate was investigated. The prepared formulations were evaluated on the basis of pH, spreadability, viscosity, drug content, in vitro release, and compatibility studies.

Results: All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value.

Conclusion: The best formulation (F4) prepared using Carbopol 940 as gelling agent showed the highest drug release through 5 h.
EFFECTS OF PHENOLIC COMPOUNDS EXTRACTED FROM SALVIA FRIGIDA ON INDUCED HYPERURICEMIA IN MICE
Authors: MUHAMMAD ABDULHUSSEIN AL-DABBAGH  , SHIHAB ABDULRAHMAN SHIHAB  , ENAS JAWAD KADHIM
Published: October 2019

Objective: The aim of this study was to investigate effects of phenolic compounds rich fraction extracted from aerial parts of Salvia frigida on serum uric acid (SUA) and xanthine oxidase (XOD) in hyperuricemic mice model.

Methods: A total of 40 albino male mice were equally divided into four groups. The blank group was given vehicles only. The model of hyperuricemia was induced by single intraperitoneal injection of UA (250 mg/kg). S. frigida group was pretreated orally with phenolic compounds rich fraction (300 mg/kg) for 6 days and one final oral dose was given directly after the UA injection on the 7th day as an acute treatment and the same was applied to allopurinol (20 mg/kg) which served as a positive control. 1 h later blood was withdrawn to be tested for SUA, XOD, and creatinine levels. Furthermore, the body weights were daily documented before each administration.

Results: The results revealed a highly comparable significant reduction in SUA and XOD in both S. frigida and allopurinol groups without significantly affecting serum creatinine compared to model group, also both modestly decreased the body weights of mice.

Conclusion: S. frigida significantly reduces SUA in the hyperuricemic model and may also have a promising effect on weight management.
STUDY ON THE CHEMICAL CONSTITUENTS OF THE ESSENTIAL OIL FROM NYCTANTHES ARBOR-TRISTIS AND ITS MOLECULAR DOCKING STUDIES
Authors: KARTHICK V  , VENKATAREDDY G  , DHARANI J  , RAVI S
Published: October 2019

Objectives: The objectives of this study were to determine the chemical composition of the essential oil obtained from the flowers of Nyctanthes arbor-tristis (NAT) and to carryout molecular docking studies against three bacterial proteins to study the mechanism of the antibacterial activity.

Methods: The essential oil was obtained from the flowers of NAT by hydrodistillation and the chemical composition was determined by gas chromatography–mass spectrometry analysis. Docking study was carried out for 14 compounds identified from NAT against three bacterial proteins 1UAG, 3TYE, and 3UDI.

Results: Fourteen compounds were identified in the essential oil. 1-octanol (74.81%) is the predominant compound followed by phytol (6.80%), bis (2-ethylhexyl) phthalate (5.88%), and eucarvone (4.23%). Many compounds are similar to that of the essential oil from jasmine. Among the 14 compounds identified, 7,9-di-tert-butyl-1-oxaspiro (4,5) deca-6,9-diene-2,8-dione interacted well with 1UAG and 3TYE and showed binding scores of −8.9 and −7.2 K Cal/mol, respectively, involving hydrophilic and hydrophobic interactions. With the protein 3UDI, the compound eucarvone exhibited a binding score of −7.1 K Cal/mol.

Conclusion: The similarities between the essential oil constituents of flowers the two plants NAT and jasmine. Therefore, it could be concluded that NAT flowers of Coimbatore are a good source of fragrance for cosmetic industry and as an antibacterial agent.
DFT Calculations and In Silico Studies on the Schiff base derivatives with Antibacterial Activities
Authors: P Arthi
Published: October 2019

Abstract

            The heterocyclic Schiff bases (N1Z,N4Z)-N1,N4-bis(3,4-methoxyphenyl)methylidene) benzene-1,4-diamine (1), (N1Z,N4Z)-N1,N4-bis(4-bromobenzylidene)benzene-1,4-diamine (2) and (N1Z,N4Z)-N1,N4-bis(furan-2-ylmethyliden)benzene-1,4-diamine (1) were synthesized by the reported procedure. The molecular structure of the compounds (1‒3) was characterized by FT‒IR and 1H NMR. The bond length, bond angle and HOMO‒LUMO energy gap were calculated out by DFT calculations. The synthesized heterocyclic compounds (1‒3) were screened for their antibacterial activity against Staphylococcus aureus and Escherichia coli. The compound 3 displays superior antibacterial activity compared to standard drug Streptomycin. All the compounds significantly interact with antibacterial protein beta-ketoacyl-acp synthase III and anticancer protein c-Kit tyrosine kinase via p–p, σ–p, hydrogen bonding, electrostatic and van der Waals interactions.
A A VALIDATED REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-CHARGED AEROSOL DETECTOR TECHNIQUE FOR THE SIMULTANEOUS ESTIMATION OF SITAGLIPTIN AND ERTUGLIFLOZIN IN PURE AND PHARMACEUTICAL DOSAGE FORMS
Authors: ANJANEYULU REDDY B  , RADHAKRISHNANAND P  , IRSHAD ALAM MD  , RAVI KIRAN P
Published: October 2019

Objective: The main objective of the present work is to develop and validate a selective reverse-phase (RP) high-performance liquid (HPLC)-charged aerosol detection technique for the quantitation of the sitagliptin and ertugliflozin in dosage form to attain high degree of sensitivity.

Materials and Methods: In present HPLC technique, separation of drugs was achieved on Phenomenex C18 column (250×4.6 mm, 5 μ) with a mobile phase composition of phosphate buffer (pH – 5.8), acetonitrile, and methanol in the proportion of 40:40:20%V/V. 1 ml/min flow rate and 256 nm wavelength detection were maintained for the elution of drugs in the chromatographic system. The retaining time of sitagliptin and ertugliflozin in column was found to be 4.2 and 2.4 min, respectively.

Results: The projected technique was successfully applied for the quantitation of sitagliptin and ertugliflozin as a single combined mixture. The linearity statistics for calibration curves shown a good linearity in the concentration range of 0.3125–10 μg/ml for sitagliptin and 0.0625–2.5 μg/ml for ertugliflozin. The average values of regression coefficient, slope, and intercept were 0.9998, 8688.2, and 1977.6 for sitagliptin and 0.9996, 33602, and 1852.6 for ertugliflozin. The technique was validated as per the International Council for Harmonization guidelines. The limit of detection and limit of quantification findings were 0.082 and 0.247 μg/ml for sitagliptin and 0.04 and 0.12 μg/ml for ertugliflozin.

Conclusion: The developed and validated RP-HPLC-charged aerosol detector technique of sitagliptin and ertugliflozin in dosage form showed that the method was accurate and selective with high degree of sensitivity.
CULTURA AUTORITÁRIA, ULTRACONSERVADORISMO, FUNDAMENTALISMO RELIGIOSO E O CONTROLE IDEOLÓGICO DA EDUCAÇÃO BÁSICA PÚBLICA
Authors: Frigotto Gaudêncio , Ferreira Sonia Maria
Published: October 2019

Este artigo busca analisar as determinações histórico-culturais que impedem que a maioria dosjovens brasileiros tenha o direito social e subjetivo do Ensino Médio. No primeiro ponto, situamos o que Karel Kosik denominou de “metafísica da cultura” para designar a concepção da realidade social como soma de fatores e não como uma estrutura de relações sociais de poder. Essa visão ahistórica, do liberalismo conservador nascente transforma-se em ultraconservadora no contexto da crise estrutural do capital. Na sequência, buscamos analisar a cultura autoritária e ultraconservadora na especificidade de nossa formação social e que, no presente, conjuga-se com o fundamentalismo religioso.
MAPEAMENTO DE GRUPOS DE TRABALHO E EDUCAÇÃO: TEMAS DE PESQUISA E INTERCRÍTICA
Authors: Lima Filho Domingos Leite , Shiroma Eneida , Da Silva Mariléia Maria
Published: October 2019

Este artigo visa contribuir com os estudos sobre o percurso do GT Trabalho e Educação daAnped, apresentando dados de um levantamento realizado em 2016 com grupos de pesquisa arespeito das temáticas privilegiadas de investigação, buscando sua articulação com os debatestravados no Intercrítica. Apresentamos o perfil dos grupos, das linhas de pesquisa tendo emvista mapear a trajetória das pesquisas da área nos 16 anos (2002-2018) de Intercrítica.Procuramos relacionar os temas tomados como objeto de estudo pelos grupos queparticiparam deste levantamento aos discutidos nas edições do evento.
Türk Destanlarında "Ant İçme" Ritüeli Üzerine Bazı Tespitler
Authors: ARVAS ABDULSELAM
Published: October 2019

Bu makalede, Türk destanlarında yer alan “ant içme” törenleri üzerine bir araştırma yapılmıştır. Bu yüzden, öncelikle, “ant”ın ne anlama geldiği üzerinde durulmuş ve bu kavramın tanımı yapılmıştır. Daha sonra ise “ant” müessesesinin Türklerdeki tarihsel süreci hakkında kısa bilgiler verilmiş ve “ant”ın ne kadar eskiye gittiği örnekler üzerinden anlatılmıştır. Bu kapsamda “ant”ın sadece tarihsel ve kültürel bir hadise olmadığı, Türk edebiyatına da yansıdığı görülmüştür. Yani, bu kısma kadar “ant” töreninin tarihî derinlikten bugüne doğru hikâyesi özet hâlinde aktarılmıştır.

Bu temel bilgilerden sonra “ant içme” ritüelinin Türk destanlarındaki yeri irdelenmiştir. Onun için Türk dünyasından yirmi destan metni incelenmiş ve bunlardaki örnekler ilgili başlıklar altında analiz edilmiştir. Buna göre, Türk destanlarında yer alan “ant içme” geleneği temelde iki işleve sahiptir ancak bunlar çeşitli alt başlıklar altında tasnif edilebilir. Türk destanlarına yansıyan “ant içme” töreninin ilk işlevi sadece söze dayanır ve bu yüzden destandaki toplum üzerinde çok etkili değildir. Bu ilk tip “ant”ta, kişi verdiği söze dair ağır bir mesuliyet taşımaz. “Ant”ın diğer işlevi ise hem geleneksel ve etkili hem de komplike bir ritüel olduğu için bağlayıcıdır. Yani bu tip “ant” kolay kolay göz ardı edilemez. Kısaca, bu araştırmada “ant içme” ritüelinin Türk destanlarına yansıma biçimleri ele alınmıştır.
Impact of Shape on Apparent Translucency Differences
Authors: Gigilashvili Davit , Urban Philipp , Thomas Jean-Baptiste , Hardeberg Jon Yngve , Pedersen Marius
Published: October 2019

Translucency is one of the major appearance attributes. Apparent translucency is impacted by various factors including object shape and geometry. Despite general proposals that object shape and geometry have a significant effect on apparent translucency, no quantification has been made
so far. Quantifying and modeling the impact of geometry, as well as comprehensive understanding of the translucency perception process, are a point of not only academic, but also industrial interest with 3D printing as an example among many. We hypothesize that a presence of thin areas in
the object facilitates material translucency estimation and changes in material properties have larger impact on apparent translucency of the objects with thin areas. Computergenerated images of objects with various geometry and thickness have been used for a psychophysical experiment in order
to quantify apparent translucency difference between objects while varying material absorption and scattering properties. Finally, absorption and scattering difference thresholds where the human visual system starts perceiving translucency difference need to be identified and its consistency
needs to be analyzed across different shapes and geometries.
Problems in Visualizing and Validating History: A Discourse on Rani by Jaishree Misra
Authors: Singh Kavita
Published: October 2019

Our Indian education system is such that we are taught a lot about history, long fought battles, wars, invaders and kings and rulers who died when and how.  In broader sense, history does not only about dates and battles, it associates and intersperses our past and present with social, cultural, religious and traditional discourses.  Our history spanning over thousand years guide our present and future. Indian writers have given their thoughts flying colors making our history unbelievably great.  They get inspired from our enormously vast past incidents and express them according to their views and idea.  There is no particular parameter which may define the history as fiction.  Indian mythological epics like Ramayana and Mahabharata have been described and redefined in numerous different ways.  India and Indian people have suffered a lot when British army ruled us for more than 200 years.  There were many brave patriots who fought for our independence.  One of such fighters is Rani Lakshmi Bai. This paper explores her life validating history through the novel, Rani.  This novel is written by Jaishree Misra.  Indian writers have explored the life and bravery of this amazingly courageous woman who redefined the womanhood and valor in her own way making a wave for the revolutionary fight for independence.
Assessing Question Formation in University Students of English Written Performance: An Evaluative Study
Authors: Hazem Mr. Ali Hussein
Published: October 2019

This work is a testing of writing execution formative assessment. A couple thinks about show firm confirmation that innovations planned to inspire the customer feedback that understudies get about their writing yield impressive learning grabs. The impression of understudies and their function in self-evaluation are viewed as close to an examination of’ the strategies employed by teachers and the formative techniques combined in such systemic philosophies as writing. There takes after a more point by point and theoretical testing of the method for feedback, which renders a reason to a discourse of the headway of speculative models for formative evaluation and of the prospects for the change of pattern.
Player Load and Metabolic Power Dynamics as Load Quantifiers in Soccer
Authors: Reche-Soto Pedro , Cardona-Nieto Donaldo , Diaz-Suarez Arturo , Bastida-Castillo Alejandro , Gomez-Carmona Carlos , Garcia-Rubio Javier , Pino-Ortega Jose
Published: October 2019

There has recently been an increase in quantification and objective analysis of soccer performance due to improvements in technology using load indexes such as Player Load (PL) and Metabolic Power (MP). The objectives of this study were: (1) to describe the performance of PL and MP in competition according to the specific role, match‐to‐ match variation, periods of play, game location and match status according to game periods, and (2) to analyze the relationship between both indexes. Twenty‐one national‐level soccer players were distributed in the following specific positional roles: external defenders (ED) (n = 4), central defenders (CD) (n = 4), midfielders (M) (n = 5), external midfielders (EM) (n = 4) and attackers (A) (n = 4). A total of 12 matches played by a Spanish Third Division team during the 2016/2017 season were analyzed. WIMU PROTM inertial devices (RealTrack System, Almeria, Spain) were used for recording the data. The main results were: (1) a performance reduction in both variables over the course of match time, (2) significant differences in both variables based on the specific position, (3) differences in physical demands during the season matches, (4) winning during a game period and the condition of being the visitor team provoked higher demands, and (5) a high correlation between both variables in soccer. In conclusion, different contextual variables influence the external load demands; both indexes are related so they could be used for external load quantification, and it is necessary to analyze physical demands of the competition for a specific and individualized load design in training sessions.
No Pain, No Gain? Prevalence, Location, Context, and Coping Strategies with Regard to Pain Among Young German Elite Basketball Players
Authors: Schneider Sven , Sauer Johannes , Berrsche Gregor , Schmitt Holger
Published: October 2019

Pain among young athletes requires special attention given that symptoms occur during the ongoing development of the conditional, and in particular, the motor capacities, and while the musculoskeletal system is in a continuous process of growth. The purpose of this study was to evaluate prevalence, location, context, and coping strategies regarding pain among young athletes. We chose survey data of young elite athletes from the highest level national basketball leagues in Germany, as this meant that health implications may be observed earlier and in a more pronounced manner. The German ‘Adolescents’ and Children’s Health in Elite Basketball study’ (ACHE study), a quantitative survey, was conducted between April and June 2016. Analyses were based on elite basketball players between 13 and 19 years of age from 46 German teams (n = 182). Constant, and to some extent severe pain, was part of daily life of young elite basketball players: eight out of ten players in the highest German leagues suffered from pain at the time of the survey. Knee, leg, and back pain occurred most frequently. For most players, occasional or frequent consumption of analgesics was the norm, in some cases these were also taken “prophylactically”. The consumption of multiple pharmaceutical substances, especially of cyclooxygenase inhibitors such as ibuprofen and diclofenac, is widespread among adolescent elite basketball players. Physicians involved in treating these athletes should address pain and its management preemptively. Coaches, sporting organizations and parents should be involved in this process from an early stage.
Trends of Goal Scoring Patterns in Soccer: A Retrospective Analysis of Five Successive FIFA World Cup Tournaments
Authors: Kubayi Alliance , Toriola Abel
Published: October 2019

This study analysed the 795 goals scored during a total of 320 matches played in five successive FIFA World Cup tournaments (1998–2014). Data were obtained through YouTube videos and analysed by means of Longomatch software. The variables analysed included the number of goals scored per half (45‐min period), per 15‐min period, and per 30‐min period of extra time, goal scoring zones, goals scored by substitutes, types of goals scored, and goals scored according to the playing position. With regard to 15‐min period analysis, most goals were scored between the 76th and 90th minutes (24.7%) of the game in all five World Cup competitions. Chi‐square analyses showed no significant (p > 0.05) differences in the frequency of goal scoring patterns per 45‐min and 15‐min periods in the five World Cup tournaments. Most goals were scored from inside the goal (23.8%) and penalty (14.6%) areas. The greatest number of goals was scored by strikers (54.2%), followed by midfielders (33.3%) and defenders (2.3%). These findings provide practical implications for improving goal‐scoring performance in soccer.
Effect of the French Contrast Method on Explosive Strength and Kinematic Parameters of the Triple Jump Among Female College Athletes
Authors: Elbadry Naglaa , Hamza Amr , Pietraszewski Przemyslaw , Alexe Dan Iulian , Lupu Gabriel
Published: October 2019

There are resistance training methods that result in strength, others that enhance hypertrophy and others that stimulate power. The training modality of contrast provides all of these benefits in one session. The concept of French Contrast training is based on a combination of complex and contrast methods. The idea is to use four exercises to induce physiological responses of the athlete and train along the force-speed curve. The primary purpose of the study was to investigate the impact of the French Contrast Method on explosive strength and kinematic parameters of the triple jump among female college athletes. Ten female college athletes from the Helwan University’s track and field team participated in this study. Participants were assessed before and after an 8-week training program for upper and lower body explosive strength. No significant differences were observed in anthropometric characteristics. Explosive strength variables (Sargent jump test, countermovement jump, and seated medicine ball throw) increased significantly and kinematic parameters of the triple jump improved. The results indicated that eight weeks of the French Contrast training can improve both explosive strength and kinematic parameters of the triple jump.