bluuebunny/crossref_metadata_2025 huggingface dataset:
In-Hospital Cardiac Arrest: Patient Characteristics and Factors Influencing Survival and Neurologic Outcomes
Authors: Cho Youngshin
Published: December 2021

Objective: We aimed to determine the characteristics of in-hospital cardiac arrest (IHCA) patients, as well as the factors influencing survival to discharge and good neurologic outcome.Methods: We examined patients who experienced IHCA from January 1, 2011, to December 31, 2013, in Soonchunhyang University Seoul Hospital. They were divided into a survival group and non-survival group. The patient characteristics, including age, sex, comorbid disease, arrest time, arrest location, witnessed arrest, monitoring, arrest cause, arrest rhythm, and cardiopulmonary resuscitation (CPR) duration, were compared between the groups. Moreover, we assessed the factors associated with survival to discharge and good neurologic outcomes by using multivariate logistic regression analysis.Results: In total, 453 patients of IHCA were observed. The comorbidities in the survival group included neurologic disease (P < 0.001), arrhythmia (P = 0.001), and myocardial infarction (P = 0.032), pneumonia (P = 0.016). Other characteristics included cardiac arrest at daytime (P = 0.032), cardiogenic arrest cause (P = 0.019), and CPR duration < 15 minutes (P < 0.001). The factors associated with survival to discharge included comorbid neurologic disease (odds ratio [OR], 2.191; P = 0.031), arrhythmia (OR, 3.027; P = 0.009), pneumonia (OR, 3.243; P = 0.002), and CPR duration < 15 minutes (OR, 9.638; P < 0.001). The factors influencing good neurologic outcomes included age < 65 years (OR, 3.158; P = 0.007), comorbid disease as arrhythmia (OR, 4.921; P = 0.001), pneumonia (OR, 4.551; P = 0.001), hypotension (OR, 4.264; P = 0.021), and CPR duration < 15 minutes (OR, 6.652; P = 0.001).Conclusion: The factors influencing survival to discharge and good neurologic outcomes among IHCA patients included comorbidities, arrest cause, and CPR duration.
Three Staged Revision Arthroplasty Using Structural Allograft in Chronic Periprosthetic Joint Infection Accompanied by Fracture: A Case Report
Authors: Kwon Sai-Won
Published: December 2021

Revision arthroplasty for chronic periprosthetic joint infection is complex and determined by many variables. Generally, two-staged revision arthroplasty is the standard treatment for the management of chronic periprosthetic joint infection. However, it is difficult to resolve chronic infection accompanied by large bone deficiency due to pathologic fracture. I report a case of successful three-staged revision arthroplasty using frozen structural allograft in chronic periprosthetic knee joint infection accompanied by extensive bone defect due to fracture.
A Case of Migration of Pipeline Embolization Device Causing Rupture during Treatment of an Unruptured Vertebral Artery Dissecting Aneurysm
Authors: Kim Sung Ho , Yeo Dong Kyu , Lee Gwang Soo
Published: December 2021

Endoluminal reconstruction of an intracranial aneurysm using flow-diverting devices, such as the pipeline embolization device (PED), is a new treatment modality with good clinical outcomes. The device was originally indicated for challenging cases, such as wide-necked large or giant aneurysms, and is gaining popularity as a reliable treatment for nearly all intracranial aneurysms. The overall complication rate of flow-diverting devices use is 17.0%, including occlusion of side-branching or perforating arteries, rerupture of the aneurysm, in-stent thrombosis, and, rarely, stent migration. We report a rare complication of the PED: delayed migration of the PED after successful stent implantation during treatment of an unruptured vertebral artery dissecting aneurysm, which resulted in rupture of the aneurysm. Further, we discuss technical steps that can be taken to prevent this potential complication.
Regional Anesthesia for Abdominal Surgery in a Patient with Severe Chronic Respiratory Failure: A Case Report
Authors: Lee Misoon , Woo Younghoon , Jung Jaewoong , Chung Yang-Hoon , Koo Bon Sung , Cho Sung-Hwan
Published: December 2021

General anesthesia is associated with a risk for postoperative pulmonary complications. The risk is even higher in patients with chronic respiratory failure, and postoperative mortality rates are high. Proper perioperative anesthetic management is important in such patients. Therefore, it is essential to optimize the patient’s physical status before anesthesia and to determine the optimal anesthesia technique based on the pre-anesthesia evaluation of the patient’s pulmonary function. We successfully performed abdominal surgery under spinal anesthesia in a patient with severe chronic respiratory failure.
A Case of Transient Neonatal Diabetes Mellitus Attributable to a Nonspecific Mutation in the ABCC8 Gene
Authors: Shin Won Seob , Jeong Hwal Rim , Koh Ji Won
Published: December 2021

Neonatal diabetes mellitus (NDM) is defined as hyperglycemia that persists for more than 2 weeks and requires insulin therapy. NDM principally occurs before 6 months of age. Transient NDM (TNDM) is a clinical form of NDM that persists for a median of 12 weeks and resolves completely by 18 months. However, it may relapse as type 2 DM during early adulthood. The major causes of TNDM are mutations in chromosome 6q24 or the KCNJ11 or ABCC8 genes; the latter encode the two subunits of the pancreatic adenosine triphosphate (ATP)-sensitive potassium channel (KATP-channel). This condition responds well to oral sulfonylurea therapy. Herein, we report a neonate who was small for gestational age and exhibited TNDM symptoms. Genetic analysis revealed a nonspecific mutation in ABCC8; he was successfully treated with oral sulfonylurea.
Successful Anesthetic Management of Myotonic Dystrophy Type I Using Sugammadex: A Case Report
Authors: Kim Suro , Chun Hea Rim , Chung Jinhun
Published: December 2021

Myotonic dystrophy (DM) is an uncommon inherited disease. Anesthesia for DM patients is tough due to its potency of cardiogenic and pulmonary problems, but a series of studies have shown how to manage and avoid complications and situations. We describe a case of a 33-year-old male patient who was scheduled for an elective excision & biopsy on the left axillae for hidradenitis suppurativa with DM type I. Anesthesia was induced and maintained with propofol, remifentanil, and rocuronium. Sugammadex is used as a reversal agent of neuromuscular blockade. He didn’t show myotonia during surgery and emergence. He also didn’t show postoperative pulmonary complications.
Primary Orthostatic Tremor in Adolescence
Authors: Kim Sung Soo
Published: December 2021

Tremor is an involuntary rhythmic muscle contraction, which causes a regular oscillation of a part of the body. Orthostatic tremor is a rare neurological movement disorder characterized by unsteadiness while standing that is relieved when sitting, walking, or lying down. Neurological examination of primary orthostatic tremor is reported to be normal. The pathophysiological mechanism of this condition is not entirely unknown. Symptoms usually start in the sixth decade. Clonazepam is widely used as a first-line medication in the treatment. A 14-year-old girl patient was admitted due to tremor activated on standing, absent while seated or lying, and improved by walking or leaning. Her brain magnetic resonance imaging and laboratory workup were normal. Tremor completely disappeared with clonazepam in 10 days. I report a case of primary orthostatic tremor in adolescence.
Constraint-based Diversification of JOP Gadgets
Authors: Tsoupidi Rodothea Myrsini , Castañeda Lozano Roberto , Baudry Benoit
Published: December 2021

Modern software deployment process produces software that is uniform, and hence vulnerable to large-scale code-reuse attacks, such as Jump-Oriented Programming (JOP) attacks. Compiler-based diversification improves the resilience and security of software systems by automatically generating different assembly code versions of a given program. Existing techniques are efficient but do not have a precise control over the quality, such as the code size or speed, of the generated code variants. 

This paper introduces Diversity by Construction (DivCon), a constraint-based compiler approach to software diversification. Unlike previous approaches, DivCon allows users to control and adjust the conflicting goals of diversity and code quality. A key enabler is the use of Large Neighborhood Search (LNS) to generate highly diverse assembly code efficiently. For larger problems, we propose a combination of LNS with a structural decomposition  of the problem. To further improve the diversification efficiency of DivCon against JOP attacks, we propose an application-specific distance measure tailored to the characteristics of JOP attacks. 

We evaluate DivCon with 20 functions from a popular benchmark suite for embedded systems. These experiments show that DivCon's combination of LNS and our application-specific distance measure generates binary programs that are highly resilient against JOP  attacks (they share between 0.15% to 8% of JOP gadgets) with an optimality gap of 10%. Our results confirm that there is a trade-off between the quality of each assembly code version and the diversity of the entire pool of versions. In particular, the experiments  show that DivCon is able to generate binary programs that share a very small number of  gadgets, while delivering near-optimal code. 

For constraint programming researchers and practitioners, this paper demonstrates that LNS is a valuable technique for finding diverse solutions. For security researchers and software  engineers, DivCon extends the scope of compiler-based diversification to performance-critical and resource-constrained applications.
A Proposal Method for Missing Value Analysis: Cluster Analysis Approach
Authors: ARCAGÖK Uğur , ARICIGİL ÇİLAN Çiğdem
Published: December 2021

Imputing values to missing cases is a subject that is frequently met in the fields of Machine Learning and Data Mining, and that require the researchers to study it. It is known that many computer-based analysis algorithms operate under assumption that there is no missing case. The lack of sufficient search of missing case by the researchers is able to negatively affect the performance of analysis results. In this study, it was studied with a data set consisting of 52 variables in order to measure the performance of Corporate Sustainability of district municipalities in Istanbul. Little’s MCAR was applied on 17 variables containing missing case, and it was determined that missing cases were MCAR, namely completely at random. And then Clustering Analysis was applied on 35 variables not containing missing case, and missing case imputations were made based on the clusters formed. It was observed that the cluster labels of municipalities, whose clustering analysis results obtained by data set with 35 variables that didn’t contain missing case, and whose results obtained by the data set with 52 variables following imputation were the same, didn’t change. The lack of change of cluster labels of municipalities indicates that the data set formed following imputation doesn’t draw away from the main data, namely that the data structure doesn’t get disrupted. Consequently, it can be said that clustering analysis is effective in terms of imputing more representative values in the imputation of missing case.
Study of morphometry and land coverage to help urban planning in Barbosa and Barbosinha Brooks watershed, Lins - SP
Authors: Lobo Isadora Vitali , Lima César Gustavo da Rocha , Lollo José Augusto Di
Published: December 2021

Urbanization in hydrographic basins promotes changes in the hydrological cycle through the impermealized areas. Not only surface runoff is increased, reducing infiltration, but also the susceptibility to extreme hydrological events. The objective of this study is to analyze the natural susceptibility of Córregos Barbosa e Barbosinha (Barbosa and Barbosinha Brooks) watershed to flooding. Morphometric parameters of land use and occupation were analyzed, in order to subsidize management and planning in an area of urban expansion. The analysis of land use and occupation was based on the supervised classification method of Landsat-5 Thematic Mapper (TM) sensor and Landsat-8 Operational Land Imager sensor (OLI) satellite images dated 1990, 2006 and 2020. Morphometric indices were calculated using the SPRING 5.4.3 software and a SRTM image with a spatial resolution of 30 meters. The results indicate that the natural susceptibility to flooding of the study area is medium to high, and can be intensified by the dynamics of land use and occupation and increasing impervious areas in the basin. Over the period of study, the growth of impervious areas was 133% relative to 1990.
Aspects of environmental comfort and sustainability in the built environment
Authors: Mello Alexandre Effori de
Published: December 2021

The objective of this article is to bring to discussion aspects of environmental comfort, built environment and sustainability, given the climate crisis and the urgency to find solutions to the issue. The concepts of ambience, quality of the built environment, environmental comfort and sustainable development are discussed, in addition to principles that can guide Architecture in its search for a built environment that preserves comfort through sustainability. The method used is bibliographical review, and the paper concludes by affirming that while it is not possible do determine the extent to which sustainability principles applied to the built environment can contribute to tackling the climate crisis, there is no other alternative.
Sanitary conditions diagnosis in vulnerable communities in the City of Recife and its influence on Covid-19 cases
Authors: Silva Gérsica Moraes Nogueira da , Menezes Athos Farias , Sobral Maria do Carmo
Published: December 2021

The Covid-19 pandemic calls into question deficiencies in current public policies and infrastructure of basic services to the population in large urban centers. From health systems, environmental sanitation and social protection, particularly for the low-income population, this opens the debate of the values and priorities at different scales. The research study area are subnormal settlements located in the neighborhoods of Pina and Brasília Teimosa in the Metropolitan Region of Recife. The aim was to assess the sanitary conditions in ZEIS, by conducting semi-structured interviews and assessing secondary data. Among the interviewees, only 56.3% said they had sanitary sewage collection and another 74.4% (n=1041) had access to water supply by Compesa, showing a significant deficit in the provision of basic services. With the pandemic, the necessary production of detailed empirical field data from the perspective of the peripheries faces great scientific challenges. Ensuring access to ideal sanitary conditions is a right for all and is related in an integrated way to multiple SDGs of the 2030 agenda. Demanding safe, adequate and affordable housing, and inclusive and sustainable urbanization, with capacity for planning and management of participatory, integrated and sustainable human settlements.
Temporal performance of the management effectiveness of a protected area in the Brazilian Atlantic Forest, São Paulo, Brazil
Authors: Faria Helder Henrique de , Pires Andréa Soares , Curi Paulo Jancar
Published: December 2021

This work presents the monitoring of the effectiveness of the management of the Morro do Diabo State Park, Sao Paulo, Brazil, during fourteen years (2002-2016), divided into six-time cuts for which management effectiveness indices were obtained. This protected area (PA) of category II of the World Conservation Union is responsible for the conservation of important species of Brazilian biodiversity, especially the leonthopitecus chrysopygus, which until the 1980s was considered the most endangered primate of the planet and which this park has its largest free population in nature. The methodological procedure used was an adaptation of the one proposed by Cifuentes, Izurieta, and Faria (2000), commonly denominated EMAP, an acronym of the initials in Spanish. The results indicate that at the beginning of the analyzed period the AP had reasonable conditions for its management, although it presented difficulties related to planning and administration, problems solved from a joint organizational and local effort, prioritizing actions for results. The management quality standard gradually increased, with a greater perception of the scope of the area's management objectives, since in addition to the ecosystem services resulting from its existence, the PA started to offer real benefits to the community by improving and increasing public use and environmental education, for example. However, the effectiveness of management has decreased to previous levels, having as main factors endogenous aspects of the management system linked to indicators limited to management, with repercussions on other management components.
De la Praça Victor Civita a la Praça da Madeira
Authors: Albano Carlos Henrique , Okimoto Fernando Sergio
Published: December 2021

Este trabajo presenta una propuesta para la aplicación de la Permacultura urbana utilizando, como trazo geográfico y socioambiental, la Praça Victor Civita ubicada en el Municipio de São Paulo. Después de ser un modelo de ubicación sostenible, el fin de la alianza público-privada llevó a la zona a un estado de abandono y la infraestructura, que solía ser ejemplar, se convirtió en un problema administrativo para el Gobierno. A través de la fundación de Placemaking, se elaboró ​​un cuestionario y se aplicó a los principales actores involucrados en el interés de recuperar la plaza, posibilitando el uso de tecnologías sociales y la implementación de la agroecología como instrumentos de reconstrucción. Al final, se convirtió en una propuesta para cambiar informalmente el nombre del lugar a “Praça da Madeira”, implementando algunos principios éticos, operativos y metodológicos y elementos habituales de la Permacultura. El producto mostró que tal método puede contribuir a una sociedad autónoma y una comunidad activa, capaz de dar un nuevo significado a los espacios públicos con cooperación e interactividad.
God-Pantocrator and God-Coordinator: The Status of a Miracle in the Scientific Revolution
Authors: Dmitriev Igor
Published: December 2021

Scientists and philosophers of the 17th century, with all the novelty of their ideas, at the same time were in no hurry to reject the concept of a miracle, although many of them, such as I. Newton, rejected the understanding of a miracle as a violation of the laws of nature, its “ordinary course”. On the whole, with regard to the Christian concept of the miracle in the natural philosophy of the early modern period, a very uncertain situation developed. On the one hand, in the era of the Scientific Revolution, there was a clear tendency to explain extraordinary phenomena by the action of natural causes, which in theology found its meaningful expression in the Protestant concept of the cessation of miracles (cessatio miraculorum) in post-apostolic times, and in philosophy (more precisely, in the philosophico-theological literature), especially in the teachings of B. Pascal, R. Descartes, B. Spinoza, D. Hume and other authors, in an effort to build a rational theology in which the status of a miracle turned out to be very uncertain. On the other hand, the difficulties that arose in science after I. Newton's discovery of the law of universal gravitation and associated with the problem of actio in distans, forced researchers to resort to theological concepts and images in natural-philosophical reasoning, in particular, to refer to the concept of a miracle. The latter circumstance required the development of a new understanding of miracles, namely the concept of “coincidence miracles”, which made it possible to preserve the apologetic functions of miracles and at the same time to neutralize the philosophical and theological criticism of the concept of miracle by B. Spinoza and D. Hume. My aim in this article is to demonstrate that the relationship between theological and scientific (more precisely, natural-philosophical) problems is by no means reduced to the use of theological concepts in the process of the formation of classical science in the mode of general reasoning by analogy or as general ideological statements. Theological concepts turned out to be included in the natural-philosophical discourse on a par with purely physical arguments, and, on the contrary, theological thought had to somehow react to natural-philosophical discoveries, which ultimately led to a mutual adjustment of both natural-philosophical and theological concepts.
Intellectual Virtue and the Epistemological Nature of Medical Evidence
Authors: Ugleva Anastasia
Published: December 2021

This article examines the problem of defining the epistemological nature of evidence in modern medicine through its two interrelated aspects — bias in the collection of data in randomized controlled trials and personal bias of the physician — which form part of the general bias problem in various professional fields. This problem is widely discussed today in the medical community, in which there is no unanimity in understanding what grounds for making the correct clinical decision are considered decisive — randomized controlled trials or the doctor's own clinical experience. In this article, it is interpreted from the point of view of the modern epistemology of virtues, which makes it possible to raise the question of the doctor's responsibility not from the position of professional deontological morality, but from the point of view of intellectual virtue. The virtuous nature of the medical profession lies in the ability of the subject to make responsible clinical decisions in the course of the cognitive process and to find the optimal balance between standardized protocols for diagnosis, prevention and treatment and their own clinical experience, which makes an individualized approach to each individual medical history possible. A standardized approach requires the “grafting” of the hermeneutic experience expressed in a general theory of understanding and interpretation. Against the background of a decrease in the level of social trust in the medical community, the substantiation of individualizing standardization as a methodologically productive way of integrating various cognitive practices is intended to help overcome the limiting abstraction of the epistemological subject in the classical epistemology of medicine and to recognize the productive-heuristic role of the doctor as a subject of cognition.
Post-Normal Science: Passing the Scylla of Uncertainty and the Charybdis of the Politicization of Knowledge
Authors: Porus Vladimir , Bazhanov Valentin
Published: December 2021

The goal of the article to assess and comprehend the legitimacy, advantages, and disadvantages of the idea of “post-normal” and “citizen science”, the problem of treating science as a political actor, as well as the potential “democratization” of contemporary science. The nature and epistemological status of “post-normal” and “citizen” science, their place, and potential role in political decision-making in situations of significant uncertainty of the future (which is especially characteristic of ecology) discussed. We are prone to emphasize the importance of the traditional criteria of rationality, dominant among scientists working under the milieu of the norms and principles of “normal” science. Despite the transdisciplinary nature of the problems and the format of decision-making that are at the core of post-normal science. Nevertheless, the political subjectivity of modern science far from being full-fledged. Science does not participate in politics in an independent actor acting on the same plane and on a par with other political actors (parties or other political structures). The acquisition by the science of the status of a political subject or the loss of such largely depends on the nature of the political climate of the society. Political subjectivity is an imitative political atmosphere that cannot be the immediate goal and value of science. Aspiration for political subjectivity as a norm for post-normal science implies a radical change in its “self-consciousness”, socio-cultural status, and thus, increasing its political weight. However, this aspiration has any reasonable theoretical and practical sense only as an integral part of the movement towards true civil society and democracy.
Blockchain as Res Publica: Towards a Political Genealogy of a Distributed Ledger
Authors: Bychkova Olga , Kosmarsky Artem
Published: December 2021

This paper focuses on the political genealogy of one of the most promising and influential IT technologies of our time: the blockchain (or distributed registry). We point at important commonalities between the principles of blockchain projects and models of republican governance. In contrast to techno-anarchist and democratic ideas, the republican genealogy of blockchain has so far failed to attract the attention of researchers. After examining the basic technical properties and ideological images of blockchain, we explore how the four main principles of classical republicanism (personal freedom and autonomy of the individual; civic virtues; common good; recognition of great causes) are realized in influential blockchain projects — Bitcoin (developed by the pseudonymous Satoshi Nakamoto) and Ethereum (developed by Vitalik Buterin). The functioning of blockchain nodes is supported by a community of miners, who are free, but at the same time agree to act for the development of a common thing. What the republic and the blockchain have in common is that it is impossible to have a community without cooperative action. At the same time, blockchain is a vivid illustration of Bruno Latour's argument on the role of non-humans in social relations: his code seeks to replace untrustworthy humans with rule-acting nodes, and to create a cryptographic society where untrustworthy human relations are replaced by computers' relations. This article is an invitation to begin a discussion of the political ideas that are embedded in new technologies and the models of governance that are mobilized through them, often without proper reflection on the nature of such ideas by their creators.
Jean-Jacques Rousseau on the Separation of Powers in Federal Polity and “Wills of Nation”
Authors: Shablinsky Anton
Published: December 2021

The problem of this article is built around the tension between the concept of organ sovereignty and democracy theory. First of all, this vision of sovereignty fails to describe the diverse forms of popular participation in collective decision-making. It speaks very sparingly of the people as a political actor. Moreover, the concept of organ sovereignty does not provide the theoretical resources to describe the intermediary bodies in the space between the state and the individual. The tradition of liberal democracy emphasises the importance of such bodies for maintaining popular control over state. Also, the idea of organ sovereignty, by reducing all power to a single legislature, ignores the demand for self-government coming from communities located within the same state and yet united by a certain collective identity. Today, democracy theorists are turning to the concepts of federalism in order to overcome the above-mentioned limitations set by the concept of organ sovereignty. So far, however, the concepts of federalism have not been very convincing in describing the various forms of popular participation in collective decision-making. Above all, they have failed to consistently justify the existence of multiple decision-making centres within a single polity. The article argues that the model of the federal polity proposed by Jean-Jacques Rousseau in his later work “Considerations on the mode of government in Poland” explains how within one polity multiple centres of collective decision-making can coexist. The model also provides an understanding of how citizen participation in multiple decision-making centres can be organised.
Magnetism of Cultures: On a Book by Robert Darnton
Authors: Winckelmann Anna
Published: December 2021

Review of: Darnton, R. 2021. Mesmerizm i konets epokhi Prosveshcheniya vo Frantsii [Mesmerism and the End of the Enlightenment in France] [in Russian]. Trans. from the English by N. Mikhaylin and V. Mikhaylin. Moskva [Moscow]: Novoye literaturnoye obozreniye.
“La Marque du Sacré”: Jean-Pierre Dupuy's Travel Log: Review of a Book by J.-P. Dupuy
Authors: Afanasov Nicolay
Published: December 2021

Review of: Dupuy, J.-P. 2021. Znak svyashchennogo [La marque du sacré] [in Russian]. Trans. from the French by A. Zakharevich. Moskva [Moscow]: Novoye literaturnoye obozreniye
Can Science be a Political Agent without a Race for Power?
Authors: Maslanov Evgeny
Published: December 2021

The article is an attempt to answer the question on the political subjectivity of modern science. It is hardly possible to speak of the specific political subjectivity of science and scientists as a conscious participation in the struggle for power. First, the race for power itself is not a major purpose for them: scientists concentrate on studying the world and creating new technologies. Second, even if they participate in such a race, they are not different from other social groups which protect their interests in political process. Changing the point of view on the political subjectivity of science enables to see its specific position in the space of the political. During discipline power and biopower formation and governmentality development, science became a basic element of public administration and politics. It forms the ideas of the objects managed, possible ways of interaction with them and creates the space of the political and management decisions implemented. In this case, social sciences and humanities obtain special political subjectivity. This also applies in a specific way to natural science and technical sciences. New scientific theories and technological solutions become representatives of non-human actors in the human world. They result in changing our ideas on “Nature”, a “scene” for history and political actions. The emergence of new non-human actors can cause the technological revolution which can influence the ways of political action implementation and provide new opportunities to execute political projects. This is an important element of the political subjectivity of science.
A Normative Model of Politically Neutral Expertise
Authors: Tukhvatulina Liana
Published: December 2021

Increasing interaction between science and politics requires analysis of the risks of science politicization. The author considers the threat of political control over the expertise and proposes a normative model which allows to avoid this threat. The author argues that the protection of the “hard core” of scientific rationality of expert’s activity is possible if the role of scientists is limited to the “technical” stage of the expertise (aggregation of scientific consensus on the problem). At this stage, the experts should make risks of the proposed strategies visible for public (the author calls this “risks externalization”). In turn, a decision on the compliance of the proposed strategies with the political interests of society should be made at the stage of open discussion. The author claims that separation of these two levels of expertise has the following advantages: (1) allows one to minimize moral and political pressure on experts; (2) makes it possible to involve all parties in the discussion, thereby neutralizing “privatization” of the public sphere; (3) allows one to aggregate distributed knowledge; (4) provides an opportunity for the distribution of responsibility among wider range of participants, thereby maintaining the democratic spirit in the community. The author criticizes the idea of “expert decisionism” and claims that it should be considered as an exceptional mode of expertise in extraordinary situation.
Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma
Authors: AVŞAR Orçun
Published: December 2021

Pheochromocytoma and Paraganglioma (PCPG) are rare and potentially lethal neuroendocrine tumors. PCPG that predominantly or exclusively produce and secrete DA is rarely seen and it has been known that exclusively dopamine-secreting PCPG is related with advanced malignant features and metastases. Up to the present, little has known about the role of dopamine neurotransmission and dopaminergic system in the initiation and progression of PCPG. The genes with significant expression differences between normal tissue and pheochromocytoma and paraganglioma, survival and correlation analysis, CpG islands prediction, and miRNA-target enrichment analysis were performed by several bioinformatics tools. In the present study, it was determined that COMT gene was significantly less expressed in PCPG than in normal tissue and COMT gene showed a remarkable relationship between differential expression with shorter overall survival among the individuals with PCPG (HR=1, p=0.011). MAOA and COMT gene pair was significantly correlated with PCPG (p=0.012; R=0.19) and hsa-miR-5000-5p regulates the expression of both COMT and MAOA genes (p=0.00215, FDR=0.127). Our findings suppose that COMT may potentially be implicated in tumor suppressive mechanism. The expression values of COMT and MAOA genes, and hsa-miR-5000-5p may have the potential to be used in the genetic evaluation of the pathogenesis and prognosis of PCPG. Further in vitro and in vivo studies are required to clarify the molecular mechanism of dopaminergic system in the pathogenesis and prognosis of PCPG.
Foam-mat Drying of Carrot Juice and Thin Layer Modeling of Drying
Authors: ÇAKMAK Hülya , ÖZYURT Vasfiye Hazal
Published: December 2021

Drying of fruit and vegetables are critical step of processing which can be very destructive for nutrients and especially for bioactive compounds. However, novel drying methods like foam-mat drying helps to decrease the drying period and exposure to drying air therefore protect the bioactives against thermal degradation as well as improving final powder quality. The foam-mat drying of carrot juice foams and modelling of experimental drying data with theoretical models has not yet been studied in the literature. In this study, the effects of foam-mat drying at 50, 60 and 70°C on the drying behavior of carrot juice with the addition of 15% egg albumen (EA) and 15% egg albumen+ 10% whey protein isolate (WPI) as foaming agents and thin-layer modeling of the foams at different thicknesses was evaluated. Compared to control sample (only carrot juice), the drying time of the foamed carrot juice was reduced by 25% to 60% depending on the foam thickness and drying temperature. This result was consistent with the effective diffusion coefficients, since the control sample had comparably low values than the 15% EA and 15% EA+10% WPI foams. Among the fitted mathematical models, Midilli et al. had better prediction capacity with the highest adjusted correlation coefficients, the lowest sum of squared error and root mean square error values for every formulation, foam thickness and drying temperatures compared to other theoretical models.
EXAMINATION OF AGGRESSION LEVELS OF WOMEN FOOTBALL PLAYERS ACCORDING TO THE USE OF CIGARETTE AND ALCOHOL
Authors: EKİZOĞLU Özlem , ACET Mehmet
Published: December 2021

Aim: This research is to reveal the aggression levels of 103 female football players playing in women's football clubs in Tekirdağ and Kütahya provinces, according to their cigarette and alcohol use. In addition, the aggression levels of the participants were examined according to their age, education, years of doing sports, the environment where they grew up and lived, and where they lived. Method: "Aggression Scale" developed by Kiper (1984) was used to obtain the research data. This scale, developed by Kiper (1984), consists of 30 items with three sub-dimensions: destructive aggression, impulsive aggression and passive aggression. Multi-Frequency Analysis, Independent Sample T-Test, and One-Way Analysis of Variance were applied by using SPSS 21.0 program in data analysis. Results: There is no difference between the aggression attitudes of female football players according to age, education, year of doing sports, the environment where they grew up and lived, and where they live (p>0.05). Conclusion: It has been determined that the aggression scores of female football players who do not smoke and alcohol are higher than those who do. Although it has been scientifically proven that smoking and alcohol use trigger aggression, our results show the opposite.
THE EFFECT OF SAFETY CLIMATE AND CULTURE ON SAFETY PERFORMANCE: AN EXAMPLE OF A MEDICAL FACULTY HOSPITAL ABSTRACT
Authors: TUNCER KARA Kevser , OĞUZÖNCÜL A. Ferdane
Published: December 2021

Aim: The aim of this study was to investigate factors affecting safety climate, safety culture, safety performance, and the effect of safety climate and culture on safety performance in Fırat University Medical Faculty Hospital. Method: The population of this cross-sectional, descriptive study consisted of doctors, midwives, nurses and other medical staff (1454 people) working at Fırat University Medical Faculty Hospital. The minimum sample size of the study was calculated as 616 with a 95% confidence interval and 3% margin of error using the Epi Info program. The data were collected through a questionnaire consisting of personal information form, safety climate scale, safety culture scale and safety performance scale. The Kolmogrov-Smirnov, Man-Whitney U, Kruskal Wallis, chi-square test, ROC, internal reliability, simple linear regression and multivariate linear regression analysis were used in data analysis. Results: The median age of the participants was 31.0. Of the participants, 50.6% were women, 61.9% were married and 38.0% had graduate or higher levels of education. It was determined that those who had information on occupational accidents and diseases had higher perceptions of safety climate, safety culture and safety performance. Furthermore, safety climate, safety culture and safety performance were positively correlated. As a result of simple linear regression, it was determined that the security climate explained 12.1% and the security culture 17.6% of security performance. Conclusion: It was concluded that trainings should be increased and repeated periodically, reporting near-miss events should be facilitated. Finally, occupational health and safety unit should be established, and inspections should be increased.
DETERMINING THE LEVELS OF CYBERBULLYING SENSITIVITY AND INTERNET ADDICTION IN HIGH SCHOOL STUDENTS
Authors: GÖGER Seda , ÇEVİRME Ayşe
Published: December 2021

Aim: This study aims to determine the levels of cyberbullying sensitivity and internet addiction among high school students. Methods: The sample of this descriptive study consists of 729 students. The study implemented data collection tools, such as “Introductory Features of Students Questionnaire Form,” “Young’s Internet Addiction Test,” and “Cyberbullying Sensitivity Scale.” The analysis of the data was completed by transferring the data to the IBM SPSS Statistics 23 program. Results: As a result of analysis, Young's Internet Addiction Test mean score was found to be 26.57 ± 8.85, while the average score of Cyberbullying Sensitivity Scale was 31.00 ± 6.43. According to some introductory features of students, a statistically significant difference was found between Young’s Internet Addiction Test and Cyberbullying Sensitivity Scale (p < 0.05). Conclusion: While the internet addiction level of participants was found to be low, their sensitivity to cyberbullying was found to be high. In an effort to deal with cyberbullying, educational programs and counseling services on internet addiction and cyber sensitivity need to be organized in schools involving parents of school children.
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Content Analysis of the APOS Theory Studies on Mathematics Education Conducted in Turkey and Internationally: A Meta-Synthesis Study
Authors: ŞEFİK Özgün , ERDEM UZUN Özge , DOST Şenol
Published: December 2021

Studies on the APOS Theory, which was developed within the context of conceptual understanding as one of the main aims of mathematics education, have been increasing in recent years. The content analysis of these studies can be useful both for the development of the APOS Theory and for identifying the needs for future research. This study aimed to review the APOS Theory studies in the field of mathematics education. For this purpose, the studies with national and international samples related to the APOS Theory were subjected to descriptive content analysis, and a systematic summary was presented. As a result of the analysis, three themes, namely the purpose of using the theory, the use of genetic decomposition, and the aim of the study were identified. It was determined that genetic decomposition, which is the main component of the APOS Theory, was not used in 13 percent of the studies reviewed. Although the theory was mainly used for data analysis, it can be said that not using genetic decomposition in data analysis is not compatible with the purpose of the theory. On the other hand, there are descriptive studies (39%) in the literature that determine the mental structures and mechanisms predicted by the APOS Theory rather than the structure of mathematical concepts. It can be said that such studies are weak in terms of the theory’s aim of reinforcing conceptual understanding. As a result, it has been revealed that, the APOS Theory has an important place in concept teaching.
Sosyal Bilgiler ve Matematik Dersi Öğrenme Kazanımlarının, Eleştirel Düşünmeyi Kazandırma Düzeyi Açısından İncelenmesi
Authors: YEŞİLPINAR UYAR Melis , TUNCA Nihal , ALKIN-ŞAHİN Senar
Published: December 2021

Araştırmanın amacı, sosyal bilgiler ve matematik dersi öğrenme kazanımlarının; eleştirel düşünme beceri ve eğilimlerini kazandırma düzeyleri açısından incelenmesidir. Araştırma, içerik analizi yöntemi temel alınarak gerçekleştirilmiştir. Verilerin toplanmasında ise doküman incelemesi yöntemi kullanılmıştır. Araştırma kapsamında incelenen dokümanları 2017 yılı temmuz ayında yürürlüğe giren Sosyal Bilgiler ve Matematik dersi (4-7. sınıflar) öğretim programları oluşturmuştur. İlgili dokümanlar aracılığıyla ulaşılan 323 öğrenme kazanımı tümdengelimsel içerik analizi yaklaşımı kullanılarak analiz edilmiştir. Verilerin analizi sürecinde araştırmacılar tarafından geliştirilen “Öğrenme Kazanımlarını Kategori ve Düzey Açısından Sınıflandırma Formu”, “Öğrenme Kazanımlarının Eleştirel Düşünme Beceri Düzeyini Değerlendirme Rubriği” ve “Öğrenme Kazanımlarının Eleştirel Düşünme Eğilim Düzeyini Değerlendirme Rubriği” kullanılmıştır. Analiz sonucunda sosyal bilgiler dersi öğretim programı öğrenme kazanımlarının, matematik dersi kazanımlarına göre eleştirel düşünme becerilerini ve eğilimlerini kazandırmada daha yeterli olduğu belirlenmiştir.
Balancing Bureaucracy and Communal Values in Diffusing the Innovation Process: Strategic Communication Challenges from the Malaysian Perspectives
Authors:   Universiti Utara Malaysia, Yusof Norhafezah , Ramli Romlah ,   Universiti Utara Malaysia, Ruangnapakul Napat ,   Maejo University, Thailand
Published: December 2021

The transmission of agricultural messages such as innovation in agricultural settings requires good planning from a strategic communication viewpoint. Moreover, there has been a call from various quarters that demand a holistic approach to solve this miscommunication issue. Thus, this study aims to understand the experiences of senior officers who are in charge of managing transmission of agricultural knowledge and training in various agriculturally based organisations. In-depth interviews were conducted with experts representing local and federal research-based and execution agencies. The data were analysed thematically. The interview protocol was developed from a literature review and tested on an expert who was also in the field of agriculture. The findings indicate that the bureaucracy system negates transfer of technology to the recipients, while communal culture presents as stimuli for successful diffusion of innovation. Thus, balancing bureaucracy and communal values offers a positive impact on the transfer of new technology to the recipients. The results offer a new understanding on the complexity of transfer of innovation knowledge and practices in terms of planning and implementing phases faced by the officers. To add, within the context of the study, top-down and bottom-up communication strategies need to be realigned to ensure the sustainability of effective innovation transfer in Malaysia. Future research could address the different scope of communication aspects in these organisations and extend our in-depth interview approach to various officers at national and regional levels. Keywords: Bureaucracy, communal values, strategic communication, experts, innovation.
Expensive molecular therapies for rare genetic disorders: carrier detection or newborn screening should be the strategy. A personal opinion.
Authors: Topaloglu Haluk
Published: December 2021

Haluk Topaloglu,Yeditepe University School of MedicineDepartment of Pediatricsİstanbul, Turkey
Rehabilitation Program “Circle of Community” in the Prevention of Deviant Behavior in Adolescents in the Center for the Promotion of Family Education
Authors: Putintseva N.V. , Vlasova N.V.
Published: December 2021

The article is devoted to the discussion of the rehabilitation program “Community Circle” and its ap-plication for the pupils of the Centers for the Promotion of Family Education. The specified program is based on a system of theoretical representations of the concept of the Rehabilitation Approach, as well as procedures and techniques used in a situation of crime, conflict, in circumstances of growing misunderstanding, alienation and tension in relations between people. The Community Circle pro-gram is a special form of organizing a dialogue that contributes to the resolution of conflict situations in an atmosphere of support and respect for the personality of the adolescents in a difficult life situa-tion, with the direct participation of all interested adults involved in his upbringing and development.
The Practice of “The Power of Folk Game” as a Component of the Project “Ecosystem of Childhood”
Authors: Chernushevich V.A.
Published: December 2021

Folklore game practice is considered as an integral part of the project “Ecosystem of childhood...” aimed at “rebooting” relations in the centers for the promotion of family education. The project focus-es on the problems of decision-making that determine the vital activity of the centers as a social sys-tem. The game practice is proposed as a special socio-cultural environment that promotes the es-tablishment of friendly, trusting, joyful relationships of participants, whose experience children trans-fer to other life situations. It is shown that the semantic core of the participants’ stay in the game is the experience of community, manifested in a sense of happiness-joy. The correctional and preven-tive possibilities of game practice in relation to many types of deviant behavior are noted. Methodo-logical recommendations are offered to the organizers of the game practice, paying attention to the peculiarities of the initiation and maintenance of the game, as a free activity of children and adoles-cents within the strict game rules.