bluuebunny/crossref_metadata_2025 huggingface dataset:
Atenuación anelástica en la Cordillera central del Océano Atlántico
Authors: Canas J. A.
Published: May 2021

Por aplicación del método de las dos estaciones se ha obtenido la atenuación del modo fundamental de las ondas de Rayleigh (componente vertical) a lo largo de la Cordillera Central del Océano Atlántico, con una extensión de unos 220 km hacia el este y el oeste de la cresta oceánica (0-11 M.a.); asimismo se ha obtenido la atenuación correspondiente a las regiones adyacentes (> 11 M.a.). La determinación de los coeficientes de atenuación así como las velocidades de grupo correspondientes a ambas regiones, ha permitido obtener los factores de calidad específica y regionalizados de las ondas de Rayleigh. La aplicación de modernos métodos de inversión a las velocidades de fase y de grupo de las ondas de Rayleigh correspondientes a la region > 11 M.a. del Océano Atlántico, ha dado como resultado la obtención de un modelo de velocidades de ondas de cizalla para dicha región. La aplicación de dichos métodos a los coeficientes de atenuación ha permitido obtener también modelos anelásticos de atenuación para las regiones 0-11 M.a. y > 11 M.a. En general, los resultados obtenidos indican que la atenuación y fricción interna son mayores bajo la Cordillera Central del Atlántico que en las regiones adyacentes. La comparación de los resultados de este estudio con los resultados obtenidos por Canas y Mitchell (1981), en una zona de la Cordillera Central Atlántica con una extensión hacia ambos lados desde la cresta oceánica de unos 460 km, indica que las variaciones de anelasticidad entre las isocronas 11 y 23 M.a. del Océano Atlántico son prácticamente despreciables. Los resultados obtenidos concuerdan con los correspondientes a estudios previos realizados en el Atlántico y en el Pacífico, en los cuales se establece que la atenuación anelástica es una función de la edad litosférica, siendo aquella mayor cuanto más moderna es la Litósfera. Este estudio soporta a su vez la reciente idea de que la fricción interna y el grado de dislocación lenta en el manto superior se hallan intimamente relacionadas.
Paleomagnetic results from southern México
Authors: Gose W. A. , Sanchez-Barreda L.A.
Published: May 2021

Análisis de resultados paleomagnéticos en muestras de las Formaciones Pérmicas lnferiores de Paso Hondo y Grupera, colectadas cerca de Chicomuselo, Chiapas, indican que el área estudiada se encontraba en relación con la parte cratónica de Norteamérica, en latitudes ecuatoriales y orientada 22° en sentido contrario a las manecillas .del reloj. En contraste, la paleoposición determinada de la Formación Pensilvánica-Pérmica Yododeñe, muestreada cerca de Nochixtlán, Oaxaca, está de acuerdo con la estimada usando datos equivalentes de Norteamérica. Estos resultados implican que el Istmo de Tehuantepec representa una discontinuidad mayor y apoyan nuestra sugerencia anterior de que Mesoamérica consistió en una serie de bloques tectónicos.
Metamorphic belts of southern Mexico and their tectonic significance
Authors: Ortega-Gutierrez F.
Published: May 2021

Los terrenos cristalinos del sur de México son subdivididos en los siguientes complejos: Oaxaqueño (Proterozoico medio), Acatlán (Paleozoico), Xolapa y "Tierra Caliente" (Paleozoico?·Mesozoico).El primero consiste en gneises bandeados de la facies de granulita, con una parte basal de ortogneis anortositico gabroide y una parte superior de paragneises calcáreos, pelfticos y cuarzo-feldespáticos, que incluyen varios intervalos de charnockita. La edad, deformación, estratigrafía y metamorfismo del Complejo Oaxaqueño son interpretados en términos de un ciclo tectónico grenvilliano. El complejo Acatlán polimetamórfico consiste en dos partes: (1) Una placa parautóctona formada por migmatita en la base, esquistos pelíticos y psamíticos congabros diferenciados en la parte media, y metasedimentos cuarzosos sin carbonatos en la parte superior. (2) Una placa alóctona formada por rocas ofiolíticas eclogitizadas, junto con abundantes granitoides milonitizados, todo ello cubierto por metasedimentos flyschoides e inmaduros. El Complejo Acatlán se interpreta en términos de un ciclo Wilson del Paleozoico, relacionado con la apertura y cierre de un océano pre-Atlántico, mejor conocido como Iapetus en el sistema orogénico Apalachiano-caledoniano. Los complejos metamórficos Xolapa y "Tierra Caliente", de edad probablemente mesozoica, parecen representar respectivamente las partes infracortical (raíz) y supracortical de arcos magmáticos y cuencas sedimentarias asociadas, que se desarrollaron en respuesta a una subducción pacifica principalmente durante la fase mesozoica del regimen tectónico Cordillerano. La construcción geológica gradual del sur de México se atribuye a los regímenes tectónicos Grenvilliano, Apalachiano y Cordillerano, cada uno de los. cuales dejó su inconfundible rúbrica en las rocas descritas brevemente en este trabajo.
Statistical analysis of stress drops in Mexico with an application to accelerations of the ground
Authors: Caputo M.
Published: May 2021

El análisis estadístico de caídas de esfuerzo, p, de 5 grupos de temblores en California y México confirma que la distribución de densidad de p es proporcional a p-l+α(α <0). El resultado había sido predicho por Caputo (1976). La distribución de densidad de p nos permite computar el período de retorno de aceleraciones del suelo (Caputo, 193la) y encontrar signos precursores de temblores (Caputo, 1981 b).
Mineral and sea salt aerosol concentrations over low latitude tropical Atlantic and Pacific oceans During FGGE
Authors: Bravo J. L. , Salazar S. , Muhlia A.
Published: May 2021

Durante los meses de enero a marzo y de mayo a julio de 1979 se realizó muestreo de aerosol atmosférico a bordo de los buques mexicanos de investigación "Mariano Matamoros" y "DM 20" en el Oceano Pacifico (7° N, 84° W) y Océano Atlántico (7°30' N, 42°30' W) respectivamente. Las componentes determinadas fueron: minerales y sales de mar. En el Océano Atlántico la media geométrica de la concentración de minerales fue de 7.27 μg/m3 y la de sales de mar 21.38 μg/m3. En el Océano Pacifíco las concentraciones de estas componentes fueron 0.62 y 6.28 μg/m3, respectivamente; en esta región son los primeros estudios que se desarrollan sobre aerosol mineral y sales de mar. En el análisis estadístico de estas dos componentes se utilizó el criterio de la x2 para la minimización del error. Para el Océano Atlántico se obtuvieron distribuciones log-normal bimodales; para el Pacífico distribuciones log-normales sencillas, lo cual estadísticamente indica la presencia de dos y un conjunto de fenómenos, respectivamente. Las concentraciones reportadas en el presente estudio para el Océano Atlántico están de acuerdo con las de otros autores. Las del Océano Pacífico son más altas que las reportadas en otras áreas de este océano.
Pulsaciones geomagnéticas tipo Pi2 registradas simultáneamente en la magnetosfera y en tierra
Authors: Costa Méndez A. D' , Torres Rivero R. , Pérez Hernández J. , Schepetnov R. V.
Published: May 2021

Se llevó a cabo un análisis comparativo de las pulsaciones Pi2 registradas en la magnetosfera y en la superficie terrestre, utilizando magnetogramas obtenidos en los satélites GOES-2 y SMS-2 y en dos estaciones terrestres (Rio Carpintero y Soroa). Las diferencias morfológicas entre las Pi2 en ambos tipos de magnetogramas, se interpretan asumiendo un modelo teórico, en el cual se propone considerar la acción de la ionosfera sobre estas pulsaciones, como la de un filtro pasa banda. Se muestra que el análisis de fase es un método adecuado para la discriminación de las Pi2 que forman un tren de ondas.
The Implemetation of Contextual Redefinition Strategy for the Improvement of Reading Skill of STMIK STIKOM Indonesia’s Students
Authors: Monny Maria Osmunda Eawea , Ni Putu Dian Indra Pratiwi  , Ni Putu Dian Indra Pratiwi
Published: May 2021

One way of improving understanding of English for Specific Purposes is through Contextual Redefinition Strategy (CRS). The implementation of CRS is meant to enhance the understanding of students of STMIK STIKOM Indonesia mostly in computers and business terms. The implementation of CRS is done through Classroom Action Research (CAR) in 3 stages of activities; those are pre-implementation, Middle Test (Cycle I) and Final Test (Cycle II). Besides, questionnaire is used with the purpose to know students’ attitude towards CRS’ implementation. The results of reading test on pre–implementation show that out of 40 students, there were 26 students did not get the lowest score 55 as the passing score of the college. After the explanation of CRS stages, middle and Final Tests tested the topics of reading texts on computers and business through search for clues in nearby words or sentences, and paragraphs of a text. Specific context clues that should be explicitly considered to understand the meaning of the sentences are definition/explanation, synonym/restatement, antonym/contrast, inference/general, and punctuation context. The results of Middle Test show that 22 students could get the score above 55, however most of students made mistakes in making redefinition based on inference/general and punctuation context. The results of Cycle II show that all students can score above 55. Besides, the results show that the students could improve their understanding for inference/general and punctuation context. The questionnaire shows that the students are motivated to acquire more and more vocabularies based on the needs for computer and business terms. The implementation of CRS does not only improve students’ ability to understand English based on its context but also enrich the vocabularies.
Discovering Hidden Messages in Covid-19 Advertisement “Stay Home Save Lives”: A Semiotic Analysis
Authors: Ni Made Desi Trisnayanti  , Desak Putu Eka Pratiwi  , Komang Dian Puspita Candra
Published: May 2021

COVID-19 (Coronavirus Disease 2019) is a disease caused by a new type of coronavirus. WHO officially declared COVID-19 as a global pandemic. Both government and non-government parties work together to educate people and provide information about COVID-19 through various ways. Advertisement is considered as one of the effective ways to provide education and understanding about COVID-19. This study aims to discover the hidden messages in COVID-19 advertisements by analyzing the verbal and non-verbal signs used in the advertisement entitled “Stay Home Save Live”. The data were collected by using observation method and note-taking technique. The data were analyzed by descriptive qualitative method using semiotic theory proposed by Saussure (1983) and the theory of meanings proposed by Barthes (1977). The analysis was presented by informal method. The finding shows that both verbal and visual signs in the advertisement “Stay Home Save Lives” have hidden message. Generally, it delivers a message that during this difficult time, people can defeat COVID-19 by staying at home, obeying the health protocol, and being positive.
The Verb “To Cut” in Nias Middle Dialect: The Study of Natural Semantic Metalanguage (NSM)
Authors: Ndruru Fransiskus , I Wayan Budiarta  , Ni Wayan Kasni
Published: May 2021

Nias middle dialect is one of dialects used by people living on Nias island that administratively belongs to North Sumatra Province of Indonesia. The lack of studies on the language especially in semantics field  was the main motivation in conducting this research. Another thing that also strongly supported the conduct of this research was a phenomenon in which some verbs semantically related to verb 'to cut' were rarely used by speakers of Nias middle dialect. Therefore, this study was conducted with the aims of discovering the verbs that have semantic relation to the verb “to cut” and describing the meaning of the verbs by employing the Natural Semantic Metalanguage theory of Wierzbicka (1996) in the qualitative research design. To collect the data, cakap method was applied which is supported by pancing and rekam techniques. In analyzing the data, padan method was applied. Based on the results of data analysis, it was revealed that there were forty-seven Nias middle dialect verbs that semantically related to the verb 'to cut'. In accordance with the results of the explication of meaning, the verbs can be classified into three groups, namely verbs that are done with tools, verbs that are done without tools, and verbs that can be done with or without tools. This phenomenon shows that Nias people do a lot of cutting activities in their social lives.
PENGARUH LIKUIDITAS, LEVERAGE DAN INTENSITAS ASET TERHADAP AGRESIVITAS PAJAK
Authors: Amalia Diah
Published: May 2021

One of the sources of State revenue is from the tax sector, the state income plays an important role in national development. Optimization in tax revenue has many obstacles, one of which is a form of non-compliance in paying taxes, researchers take the factor of liquidity, leverage, intensity of fixed assets and inventory intensity to determine the effect on tax aggressiveness. This study aims to examine the effect of liquidity, leverage, and intensity of fixed assets on tax aggressiveness in manufacturing companies listed on the Indonesia Stock Exchange (IDX) for the period 2013-2017. Through a purposive sampling method, researchers obtained 60 sample companies. The data analysis technique used is multiple linear analysis. The research results obtained are leverage factors that influence the level of corporate taxpayer aggressiveness while the liquidity factor, the intensity of fixed assets does not affect the level of tax aggressiveness
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PROFITABILITAS DAN IMPLIKASINYA PADA CORPORATE VALUE
Authors: Aria Aji Priyanto
Published: May 2021

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi Profitabilitas Perusahaan yang terdiri dari Ukuran Perusahaan, Likuiditas dan Leverage untuk mengetahui implikasinya terhadap Corporate Value. Corporate value diukur menggunakan perhitungan Indeks Tobins Q. Jenis penelitian ini menggunakan kausal komparatif dengan pendekatan kuantitatif. Populasi penelitian ini adalah perusahaan Sub Sektor Transportasi yang terdaftar di Bursa Efek Indonesia selama tahun 2010-2017 dengan penetapan sampel akhir 7 perusahaan. Metode analisis data dilakukan dengan analisis jalur dan menggunakan teknik sobel test.  Faktor-faktor yang mempengaruhi Profitabilitas yang terdiri dari Ukuran Perusahaan, Likuiditas dan Leverage hanya dibuktikan melalui likuiditas berpengaruh negatif terhadap profitabilitas perusahaan sedangkan profitabilitas berpengaruh positif terhadap corporave value. Ukuran Perusahaan dan leverage tidak berpengaruh signifikan terhadap profitabilitas perusahaan. Akhirnya, faktor Ukuran Perusahaan, Likuiditas, dan Leverage pada penelitian ini tidak mampu mengevaluasi Corporate Value melalui Profitabilitas yang difungsikan sebagai variabel intervening.
OPTIMALISASI PROFITABILITAS PERBANKAN MELALUI PENGELOLAAN KECUKUPAN MODAL DAN LIKUIDITAS SERTA RISIKO KREDIT
Authors: Wardani Made Kusuma , Ningsih Ni Luh Anik Puspa , Dewi Made  Pratiwi
Published: May 2021

Sebagai lembaga intermediary, bank berfungsi menerima serta menyalurkan dana serta berperan dalam transaksi keuangan lainnya. Bank dalam menghadapi persaingan di industry perbankan, hendaknya memiliki kinerja yang stabil dan bahkan meningkat. Salah satu ukuran pencapaian kinerja perbankan adalah profitabilitas. Profitabilitas merupakan kemampuan perusahaan dalam menghasilkan keuntungan (laba). Adapun tujuan dari penelitian ini untuk menganalisis optimalisasi profitabilitas perbankan melalui pengelolaan kecukupan modal dan likuiditas serta risiko kredit. Penelitian ini meneliti salah satu lembaga keuangan mikro yaitu BPR. Populasi dari penelitian ini adalah BPR di Provinsi Bali berjumlah 136 perusahaan. Dengan metode purposive sampling diperoleh sampel sebanyak 39 perusahaan. Penelitian ini mempergunakan data sekunder dari laporan keuangan BPR dengan teknik analisis Path Analisis. Berdasarkan hasil analisis ditemukan, (1) Kecukupan Modal  berpengaruh positif dan signifikan terhadap Profitabilitas, (2) Likuiditas berpengaruh positif dan signifikan terhadap Profitabilitas, (3) Risiko Kredit berpengaruh negatif dan signifikan terhadap Profitabilitas, (4) Kecukupan Modal berpengaruh positif dan signifikan sebesar terhadap Risiko Kredit, (5) Likuiditas  berpengaruh negatif dan tidak signifikan terhadap Risiko Kredit, (6) Risiko Kredit  tidak mampu memediasi kecukupan modal terhadap nilai Profitabilitas (7) Risiko Kredit  tidak memediasi likuiditas terhadap Profitabilitas
Weaknesses Of Judges Thinking In Civil Law Systems
Authors: Wijaya Made Hendra
Published: May 2021

Judge’s an instrument of justice that are at the forefront in enforce the justice in society, but sometime the judge’s decision does not represent justice in society, because the judge’s in conducting the trial should follow existing the systems. Just as judge’s as adherent of the civil law system. In this paper describes the civil law system, started from Roman era, German, Francis, as well as elements of a definition of the civil law systems, and then discusses the judges in the civil law system, and discuss any weaknesses civil law2 judges in terms of implementing the trial in finding justice in society.
The Legal Impact on People Died in Kasepekang Sanction
Authors: Dewi Ni Made Trisna
Published: May 2021

The Pakraman village is led by village officers. The issue of how to implement the Kasepekang sanction is very important to analyse because fraud or abuse of power often occurs in this sector. Kesepekang the term of traditional sanctions in the form of a temporary dismissal as a member of the banjar and pakraman villages. Those affected by this sanction are not entitled to receive banjar service / assistance and pakraman villages. This type of research is empirical legal research oriented to the collection of empirical data in the field. Based on this empirical data the researcher conducted an in-depth analysis in accordance with the relevant theory to make conclusions. Kasepekang sanctions are given because community members do not want to solve and conduct paruman to find solutions to adat problems. Based on paruman adat leaders and community representatives prescribed on Awig-awig Number 18, paragraph 14 regarding unwritten regulations, it was decided by the village of Pakraman Pempatan and it was agreed that the person be subject to a sanction of being left unchecked. This case was motivated by civil problems continued with the existence of actions and reactions, developed into a criminal problem that is the desecration of the holy place and customary matters.
AS MÚLTIPLAS LEITURAS DA METÁFORA NO TEXTO LITERÁRIO: UMA CONTRIBUIÇÃO PARA A FORMAÇÃO DO LEITOR PROTAGONISTA E REFLEXIVO
Authors: Sugayama Ariane Mieco
Published: May 2021

Em busca de uma formação do leitor literário mais protagonista e reflexivo, este artigo analisa as múltiplas leituras da metáfora do poema ‘Rosa”, de Cecília Meireles, geradas na prática de leitura dialógica e colaborativa Pensar Alto em Grupo, no que se refere à coconstrução e à negociação dos sentidos. Pretende-se, ainda, investigar de que maneira as metáforas conceptuais participaram do processo de compreensão das metáforas poéticas.
SURDEZ, RECONTO E FORMAÇÃO LEITORA
Authors: Rosendo de Souza José Marcos , Costa Maria da Conceição , Pessoa Sampaio Maria Lúcia
Published: May 2021

As pesquisas com formação leitora têm suscitado algumas discussões e mudança de posturas ao desenvolvimento de leitores plenos. Contudo, as metodologias que primam pela proficiência de leitores Surdos são escassas. Aqui discutimos a formação leitora de um aluno Surdo a partir de uma pesquisa interventiva, com abordagem cognitiva. A formação leitora de Surdos será possível com adequada metodologia à Surdez.
Comportamiento termoluminiscente de matrices de alúmina bajo diferentes condiciones de sinterización y dopaje con cerio
Authors: Rojas-Pérez Jorge Armando , Cogollo-Pitalúa Rafael Ricardo , Gutiérrez-Flórez Omar Darío
Published: May 2021

Introducción: en la búsqueda de nuevos materiales útiles como dosímetros termoluminiscentes (TL) la alúmina (α-Al2O3) ha adquirido gran atención. La α-Al2O3 posee una sensibilidad TL que es perceptible a las concentraciones de impurezas y a las condiciones térmicas del crecimiento de sus cristales, por lo que encontrar nuevas variaciones del material permitirá aumentar su respuesta TL. Objetivo: analizar las curvas de brillo de matrices de alúmina pura sinterizadas bajo diferentes condiciones de calcinación y dopadas con cerio a concentración 0.1 % p/p (Al2O3:Ce), usando la función asimétrica logística, para calcular sus parámetros cinéticos termoluminiscentes y explicar el comportamiento del material. Materiales y métodos: polvo de alúmina bohemita fue utilizado para preparar muestras puras sinterizadas de bajo diferentes condiciones de calcinación (NALO y ALO). El cerio se introdujo mediante impregnación húmeda utilizando nitrato de cerio hexa-hidratado. El análisis estructural de las matrices se realizó mediante Difracción de Rayos X. La lectura TL se realizó en un TLD 4500. Resultados: la deconvolución obtenida en las curvas de brillo para los grupos ALO y NALO evidencia la presencia de tres y cuatro señales TL respectivamente, y de seis señales TL en la muestra Al2O3:Ce. Conclusión: los tratamientos térmicos aplicados introdujeron un cambio sustancial en la curva de brillo del material y en su cinética TL, en términos del número de trampas y de la cantidad inicial de portadores de carga atrapados. La introducción de impurezas de cerio produjo una modificación fundamental en la curva de brillo de las matrices de alúmina.
Hacia una exposición científica del arte
Authors: Tirado-de la Chica Ana
Published: May 2021

Introducción: este trabajo aborda el problema del estatismo de la exposición de arte que, a diferencia de la exposición de ciencias y de museos de historia social, que han recibido un giro de enfoque científico y socio-cultural, respectivamente, la manera de exponer el arte permanece según el arquetipo de galería de arte. Objetivo: el objetivo principal es conocer cómo opera la información teórica y de fundamentación en la exposición de arte. Materiales y métodos: se realiza un estudio comparado de dos casos internacionales de exposición de arte. Una es Itinerarios del vértigo (2015), con obra de la colombiana Sandra Silva, en el Museo de Arte de Pereira, Colombia. La otra es La invención concreta (2013), con obra latinoamericana de la colección de arte de la Fundación “Patricia Phelps de Cisneros”, en el Museo Nacional Centro de Arte “Reina Sofía” de Madrid, España. El método es de tipo cualitativo, basado en técnicas etnográficas para la recogida de datos y en técnicas de codificación y clasificación de los datos para el análisis, según tres descriptores clave: objetos que se expone en sala, estética-arquitectónica e información interna. Resultados: se refieren a dos tipos de exposición y desde una perspectiva de la transferencia del conocimiento artístico: una transferencia aplicada a la obra de arte y, otra, aplicada a dispositivos estético-artísticos que también son expuestos en sala. Conclusiones: sas conclusiones están dedicadas a aquellos aspectos más significativos para una exposición científica del arte según esta transferencia.
H63D Syndrome: What we know about it in 2021
Authors: Diamandis Dr. Carolina , Adams Jacob S , Honda Riku , Papadopoulos Anastasios , Smith Lucas , Kaufmann Marianne , Lazar Marius , Diamandis Carolina , Seideman David
Published: May 2021

H63D syndrome is a serious and clinically progressive disorder of iron
metabolism caused by non-transferrin-bound iron (NTBI). In 2019, after
scientists from around the world joined together to form the H63D
Syndrome Research Consortium (a non-profit entity), a consensus paper
“H63D Syndrome” was adopted at a meeting in Oslo in December 2019.
With this new paper, we summarize what the leading experts in the field
know about the syndrome in 2021.
Extreme warming restructures habitat distribution and productivity along local gradients in stress and biodiversity
Authors: Whalen Matthew , Starko Sam , Lindstrom Sandra , Martone Patrick
Published: May 2021

Significant questions remain about how ecosystems that are structured by
abiotic stress will be affected by climate warming. A well-supported
hypothesis states that warming will cause species to shift along abiotic
gradients, such that distributions track changing local conditions.
Here, we investigated the impacts of a multi-year heatwave on community
dynamics and zonation in one such ecosystem: rocky intertidal
communities. We demonstrate that, while populations generally shifted
downslope towards reduced abiotic stress, species were impacted to
varying degrees, leading to complex changes in community and ecosystem
dynamics. Warming generally shifted primary production away from upper
elevations through synchronized seaweed declines and replacement by
invertebrates, while high producer biomass was maintained at lower
elevations through compensatory dynamics that resulted in novel
community composition. Our results illustrate that, rather than shifting
community zonation uniformly along local gradients, warming will
restructure habitat archetypes and redirect pathways for energy transfer
in stress-structured systems.
Aortic Proximalisation -- Zone 0 vs. Zone 2. A Concept or True Challenge?
Authors: Tan Cian , Lopuszko Aleksandra , Munir Wahaj , Bashir Mohamad , Adams Benjamin
Published: May 2021

Background Use of the Frozen Elephant Trunk (FET) device to manage
complex surgical pathologies of the aorta (e.g. acute Type A aortic
dissection) has gained popularity since its introduction in the early
2000s. Though the distal anastomosis was traditionally performed at Zone
3 (Z-3-FET), preference gradually shifted towards Zone 2 (Z-2-FET) in
favour of improved surgical access and outcomes. This review seeks to
elucidate whether proximalisation of arch repair to Zone 0 (Z-0-FET)
would further improve postoperative outcomes. Methods We performed a
review of available literature to evaluate the comparative efficacies of
Z-2-FET versus Z-0-FET, in terms of surgical technique, clinical
outcomes, and incidence of adverse events. Results Z-0-FET seems to be
associated with a more accessible surgical approach, and shorter
cardiopulmonary bypass, antegrade cerebral perfusion, and cardioplegia
durations than Z-2-FET. Further, Z-0-FET is could potentially be
associated with a lower incidence of neurological, renal, and recurrent
laryngeal nerve injury, as well as mortality and reintervention rates
than Z-2-FET. This said, Z-0-FET is itself associated with significant
challenges, and efficacy in terms of postoperative true lumen integrity
and false lumen thrombosis is mixed. Conclusion Current literature seems
to suggest that Z-0-FET procedures are more straightforward and
associated with lower rates of certain adverse events, however, the
majority of data reviewed is retrospective. This review therefore
recommends prospective research into the comparative strengths and
limitations of Z-0-FET and Z-2-FET to better substantiate whether
proximalisation of arch repair represents a concept, or a true challenge
to advance surgical intervention for arch pathologies.
Efficacy and safety of ruxolitinib in ineffective erythropoiesis suppression as a pre-transplantation treatment for pediatric patients with beta-thalassemia major
Authors: Ovsyannikova Galina , Balashov Dmitry , Demina Irina , Shelikhova Larisa , Pshonkin Alexey , Maschan Michael , Novichkova Galina , Maschan Alexei , Smetanina Nataliya
Published: May 2021

Background: Ineffective erythropoiesis (IE) is the most prominent
feature of transfusion-dependent beta-thalassemia (TDT), which leads to
extramedullary hemopoiesis. The rejection rate in allogeneic
hematopoietic stem cell transplantation (HSCT) is clearly superior in
heavily transfused patients (pts) with TDT accompanied by prominent IE.
Therefore, a pre-transplantation treatment bridging to HSCT is often
used to reduce allosensibilization and IE. Ruxolitinib (RUX) is a
JAK-1/JAK-2-inhibitor and has showed its efficacy to suppress IE and the
immune system. A previously published study on RUX in adult pts with TDT
has revealed that this treatment significantly reduces spleen size and
is well tolerated. Procedure: Ten pts (5-14 y.o.) with TDT and an
enlarged spleen were enrolled. The dose of RUX was adjusted for age: for
pts younger < 11 years: 40 - 100 mg/m2 and for pts
>11 years: 20 - 30 mg/m2. HSCT was performed in 8 out of
the 10 pts. Results: After the first 3 months of RUX therapy the spleen
volume decreased in 9 out of the 10 cases by 9.1 – 67.5% (M = 35.4%)
compared to the initial size (р = 0.003). The adverse events of RUX
included infectious complications, moderate thrombocytopenia as well as
headache and were successfully managed by reducing the dose. The
outcomes of HSCT were favorable in 7 out of the 8 cases. Conclusion: RUX
is promising as a short-term pre-HSCT treatment for pediatric pts with
TDT and pronounced IE.
Mechanobiological conceptual framework for assessing stem cell bioprocess effectiveness
Authors: Kim Mee-Hae , Kino-oka Masahiro
Published: May 2021

The realization of the enormous potential of stem cells requires
development of efficient bioprocesses and optimization drawing drawn
from mechanobiological considerations. Here, we emphasize the importance
of mechanotransduction as one of the governing principles of stem cell
bioprocesses, underscoring the need to further explore the behavioral
mechanisms involved in sensing mechanical cues and coordinating
transcriptional responses. We identify the sources of the intrinsic,
extrinsic, and external noise in bioprocess under uncertainty, and
discuss criteria and indicators that might assess and predict
cell-to-cell variability resulting from environmental fluctuations.
Specifically, we propose a conceptual framework to explain the impact of
mechanical forces within cellular environment and identify key cell
state determinants in bioprocess and discuss their implementation
challenges.
Comprehensive Data Analytics Project Using Excel and Tableau for the Sales and Purchases Cycles
Authors: Schuele Karen , Felski Elizabeth
Published: May 2021

Using materials from PwC's data analytics case study using a fictitious company, Pixystems Toy Company, Inc. (PwC 2017), the authors developed a comprehensive, multi-part data analytics project that is applicable for a variety of accounting courses. The project follows the common data analytics framework (ask the right questions, extract, transform, and load [ETL] the data, perform appropriate analyses, and present the results). Students apply this framework to the sales and purchases cycles. For each, students develop relevant questions, build a data model, and perform other ETL procedures, perform analytics, and prepare a presentation to convey insights and recommendations. For the sales cycle, Microsoft Excel is the analytics tool; for the purchases cycle, Tableau is used. This project provides an opportunity for students to gain experience with two analytics tools, understand the process of building a data model, and wrestle with how to convey the results of their analysis.
Impact of early extraction of the deciduous canine on relief of severe crowding:
Authors: Aljabab Mhanna A. , Algharbi Muteb , Huggare Jan , Bazargani Farhan
Published: May 2021

Objectives

To explore whether there were any differences in orthodontic treatment need, treatment complexity, treatment time, or the number of visits between a group of children receiving early intervention (extraction of upper and lower deciduous canines) and an age- and condition-matched control group without intervention.

Materials and Methods

Patient records and study casts in the late mixed or early permanent dentitions of 46 subjects (20 from the extraction group and 26 from the control group) of an earlier prospective longitudinal study were retrieved. Orthodontic treatment need and complexity were assessed by the index of complexity, outcome, and need (ICON). Statistical calculations were performed by t-test for parametric outcome variables (treatment time, number of visits, and orthodontic treatment need) and Fisher exact test for the categorical variable (tooth extractions).

Results

There were no statistically significant differences between the groups in ICON scores of orthodontic treatment need (extraction group, mean score 59.8; control group, mean score 52.8), number of visits (mean of about 15 visits for both groups), or treatment time (extraction group, mean 21.5 months; control group, mean 20.3 months). The extraction of permanent teeth was more prevalent in the deciduous canine extraction group (59%) as compared with the control group (28%); however, this was not statistically significant (P = .07) but showed a tendency toward worsening the crowding and the future need of orthodontic extractions.

Conclusions

Early removal of deciduous primary canines will reduce neither the need for later orthodontic treatment nor its complexity, nor will it shorten the treatment time.
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes
Authors: Hiller Helmut , Beachy Dawn E. , Lebowitz Joseph J. , Engler Stefanie , Mason Justin R. , Miller Douglas R. , Kusmarteva Irina , Jacobsen Laura M. , Posgai Amanda L. , Khoshbouei Habibeh , Oram Richard A. , Schatz Desmond A. , Hattersley Andrew T. , Bodenmiller Bernd , Atkinson Mark A. , Nick Harry S. , Wasserfall Clive H.
Published: May 2021

Type 1 diabetes (T1D) has a multifactorial autoimmune etiology, involving environmental prompts and polygenic predisposition. We hypothesized that pancreata from individuals with and at risk for T1D would exhibit dysregulated expression of genes associated with monogenic forms of diabetes caused by nonredundant single-gene mutations. Using a “monogenetic transcriptomic strategy,” we measured the expression of these genes in human T1D, autoantibody-positive (autoantibody+), and control pancreas tissues with real-time quantitative PCR in accordance with the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines. Gene and protein expression was visualized in situ with use of immunofluorescence, RNAscope, and confocal microscopy. Two dozen monogenic diabetes genes showed altered expression in human pancreata from individuals with T1D versus unaffected control subjects. Six of these genes also saw dysregulation in pancreata from autoantibody+ individuals at increased risk for T1D. As a subset of these genes are related to cellular stress responses, we measured integrated stress response (ISR) genes and identified 20 with altered expression in T1D pancreata, including three of the four eIF2α-dependent kinases. Equally intriguing, we observed significant repression of the three arms of the ISR in autoantibody+ pancreata. Collectively, these efforts suggest monogenic diabetes and ISR genes are dysregulated early in the T1D disease process and likely contribute to the disorder’s pathogenesis.
Glycemic Control, Diabetic Complications, and Risk of Dementia in Patients With Diabetes: Results From a Large U.K. Cohort Study
Authors: Zheng Bang , Su Bowen , Price Geraint , Tzoulaki Ioanna , Ahmadi-Abhari Sara , Middleton Lefkos
Published: May 2021

OBJECTIVE

Type 2 diabetes is an established risk factor for dementia. However, the roles of glycemic control and diabetic complications in the development of dementia have been less well substantiated. This large-scale cohort study aims to examine associations of longitudinal HbA1c levels and diabetic complications with the risk of dementia incidence among patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS

Data of eligible patients with diabetes, aged ≥50 years in the U.K. Clinical Practice Research Datalink from 1987 to 2018, were analyzed. Time-varying Cox regressions were used to estimate adjusted hazard ratios (HRs) and 95% CIs for dementia risk.

RESULTS

Among 457,902 patients with diabetes, 28,627 (6.3%) incident dementia cases were observed during a median of 6 years’ follow-up. Patients with recorded hypoglycemic events or microvascular complications were at higher risk of dementia incidence compared with those without such complications (HR 1.30 [95% CI 1.22–1.39] and 1.10 [1.06–1.14], respectively). The HbA1c level, modeled as a time-varying exposure, was associated with increased dementia risk (HR 1.08 [95% CI 1.07–1.09] per 1% HbA1c increment) among 372,287 patients with diabetes with postdiagnosis HbA1c records. Similarly, a higher coefficient of variation of HbA1c during the initial 3 years of follow-up was associated with higher subsequent dementia risk (HR 1.03 [95% CI 1.01–1.04] per 1-SD increment).

CONCLUSIONS

Higher or unstable HbA1c levels and the presence of diabetic complications in patients with type 2 diabetes are associated with increased dementia risk. Effective management of glycemia might have a significant role in maintaining cognitive health among older adults with diabetes.
The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure-Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial
Authors: Nguyen Tu N , Harris Katie , Woodward Mark , Chalmers John , Cooper Mark , Hamet Pavel , Harrap Stephen , Heller Simon , MacMahon Stephen , Mancia Giuseppe , Marre Michel , Poulter Neil , Rogers Anthony , Williams Bryan , Zoungas Sophia , Chow Clara K , Lindley Richard I
Published: May 2021

Objective. To
develop a frailty index (FI)
and explore the relationship of frailty to subsequent
adverse outcomes on the effectiveness and safety of more intensive control of
both blood glucose and blood pressure (BP), amongst participants with type-2
diabetes in the Action in Diabetes and Vascular Disease: Preterax and Diamicron
Modified Release Controlled Evaluation (ADVANCE) trial.

Research Design and
Methods. Cox
proportional-hazard models were
used to estimate the effectiveness and safety of intensive glucose control and
BP intervention according to frailty (defined as FI>0.21) status. The
primary outcomes were macrovascular events and microvascular events. The
secondary outcomes were all-cause mortality, cardiovascular mortality, severe
hypoglycaemia, and discontinuation of BP treatment due to hypotension/dizziness.

Results.
There were 11140 participants (mean age 65.8, 42.5% female, 25.7% frail). Frailty
was an independent predictor of all primary outcomes and secondary outcomes. The
effect of intensive glucose treatment on primary outcomes showed some evidence
of attenuation in the frail: HRs for combined major macro- and micro-vascular
events 1.03, 95%CI 0.90-1.19 in the frail vs 0.84, 95%CI 0.74-0.94 non-frail
(p=0.02). A similar trend was observed with BP intervention. Severe hypoglycaemia rates (per 1000 person-years) were higher
in the frail: 8.39 (6.15–10.63) vs. 4.80 (3.84–5.76) in non-frail
(p<0.001). There was no significant difference in discontinuation of BP
treatment between frailty groups.

Conclusions. It
was possible to retrospectively estimate frailty in a trial population, and
this FI identified those at higher risk of poor outcomes. Participants with
frailty had some attenuation of benefit from intensive glucose lowering and BP
lowering treatments.
Does Blood in Urine Have Effect on Tooth Decay?
Authors: Mureed Yasmeen
Published: May 2021

Main Objective of the study was to determine the relation of tooth decay with blood in urine. A total of the 100 students participated get involved in this study. The students were from Bahauddin Zakariya University Multan, Pakistan. Project was designed to see indifferent individuals either they had tooth decay or not. Urinary tract is a part of human body and it allows the blood cells to leak into urine. Due to this leakage of blood into the urine causes many problems and infections of the urinary tract. The results collected showed that negative value had the relation with the blood in urine. While in case of hemolytic and non-hemolytic had no impact on blood in urine. While in case of females there was great value that had relation with tooth decay. While hemolytic and non-hemolytic had no relation with tooth decay. It was concluded that there was relation of tooth decay with blood in urine.
Lichentherapy: Highlights on the Pharmaceutical Potentials of Lichens
Authors: WA Elkhateeb
Published: May 2021

Lichens exist in every continent and have a history of being used as food, medicine, a source of dyes and animal feed. Lichens are now being used as natural indicators of climate change and for air quality monitoring worldwide. Lichens play an important role in many ecosystems and exist as a symbiotic association between fungi and algae or cyanobacteria. This symbiosis results in the production of unique secondary metabolites known as lichen substances, which arise within the thalli and are typically in crystal form on the surface of the fungal hyphae. Recently, lichens and their secondary metabolites have been receiving increased attention due to their nutritional value and pharmaceutical potential. This review aims to highlight on the importance and variety of common lichen substances (secondary metabolites). Finally, the commercialization of lichens is growing but, in the future, metabolic and biotechnological approaches can be used as an alternative product to overcome the limited availability of biologically active, commercially valuable and medicinally important secondary metabolite components.
Caronas Colaborativas em Comunidades Virtuais: O Papel da Consciência de Coletivismo e do Descontentamento com os Serviços de Transporte Público
Authors: Macêdo Álison Lima , Pinheiro Eline Morais , Filho Jeferson Mendonça Pereira , Costa Marconi Freitas
Published: May 2021

Esta pesquisa delineou identificar qual influência a Consciência de Coletivismo (CC) e o Descontentamento com os Serviços de Transporte Público (DSTP) poderiam gerar sobre a intenção de participar de caronas colaborativas em comunidades virtuais. Assim, utilizou-se da abordagem quantitativa descritiva e inferencial, tendo o survey online como estratégia para  pesquisa e aplicação de questionários estruturados, atingindo um total 129 participantes, validados segundo os critérios da investigação. Portanto, os dados foram verificados por meio da análise de regressão múltipla, identificando que dos dois construtos apontados no modelo teórico como influenciadores, mesmo considerando fatores negativos existentes do DSTP, apenas a CC apresentou resultado significativo na intenção de participar. Essa pesquisa apresenta caráter inédito, investigando um fenômeno pouco estudado no consumo colaborativo. No contexto social e mercadológico, apresenta-se dados auxiliadores no entendimento do comportamento desse público e no atendimento de suas necessidades pelos setores de serviços.
Trauma Organizacional em Tempos de COVID-19: Contribuições para a Gestão de Pessoas
Authors: Camilo Juliana Aparecida de Oliveira
Published: May 2021

Organizações podem ser confrontadas com situações traumáticas, causando impactos em suas operações, processos e coletivo de trabalhadores. Neste momento, passam a funcionar de modo adoecido, não conseguindo executar suas funções como antes, podendo, se tornar não efetivas no seu fazer ou até perigosas para sua clientela e/ou a saúde de seus trabalhadores. Por este motivo, o  presente estudo apresenta o conceito de Trauma Organizacional em organizações de saúde que atuaram na chamada “linha de frente” da COVID-19, a partir da realidade  brasileira, e as contribuições possíveis para a área de Gestão de Pessoas. Para tanto, procura sustentação a partir do construcionismo social, apresentando ferramentas de identificação do TO, visando mediações possíveis para a área de Gestão de Pessoas.
Produção e Reprodução Acadêmica: O Produtivismo e a Lógica Gerencialista na Pós-Graduação em Administração
Authors: Mourad Aimãn Ibrahim
Published: May 2021

Não são novas as discussões em torno do produtivismo acadêmico instalado entre os pesquisadores e as instituições de ensino como consequência dos modelos de avaliação adotados pelos principais órgãos do sistema de educação nacional. Sabemos que o produtivismo não é exclusivo da área da administração, mas não deixa de ser irônico que dentro da academia nós continuemos reproduzindo uma lógica gerencialista (que tanto ensinamos em sala de aula) para a produção de conhecimento como um produto comercializado de maneira competitiva e sem nenhuma visão crítica desta situação.
Competências empreendedoras e satisfação no trabalho se refletem no desempenho organizacional em empresas de micro e pequeno porte?
Authors: Moretto Suely Parente , Silveira Amelia
Published: May 2021

Resumo: O desempenho organizacional tem requerido comportamentos empreendedores nas organizações, e a satisfação no trabalho é fator importante para esse desempenho. Objetivou-se avaliar a relação positiva entre a competências empreendedoras e a satisfação no trabalho com o desempenho organizacional de micro e pequenas empresas, em cidade do Nordeste do Brasil. Foram pesquisadas 35 empresas que apresentavam o Setor de Recursos Humanos estruturado, com Gestor de Recursos Humanos. A pesquisa foi descritiva, com método quantitativo. Adotaram-se questionários para a coleta de dados. A análise estimou média, desvio padrão, coeficiente de variação, assimetria e curtose de cada variável; adotou a análise de variância (ANOVA) e a análise de correlação. Os resultados confirmaram, positivamente, as três hipóteses do estudo. Ficou evidente o forte índice do conjunto de planejamento quando comparado à satisfação no trabalho e ao impacto significativo sobre o desempenho oranizacional.
Reaction kinetics and macromolecule-metal chelate complex formation in metal containing semi-interpenetrating polymer networks based on crosslinked polyurethane and linear polymethylmethacrylate
Authors:   Institute of Macromolecular Chemistry of National Academy of Sciences of Ukraine, 48 Kharkov chaussee, 02160 Kiev, Ukraine, Kosyanchuk Ludmila , Kozak Nataly ,   Institute of Macromolecular Chemistry of National Academy of Sciences of Ukraine, 48 Kharkov chaussee, 02160 Kiev, Ukraine, Antonenko Oksana ,   Institute of Macromolecular Chemistry of National Academy of Sciences of Ukraine, 48 Kharkov chaussee, 02160 Kiev, Ukraine, Nizelskii Yury ,   Institute of Macromolecular Chemistry of National Academy of Sciences of Ukraine, 48 Kharkov chaussee, 02160 Kiev, Ukraine
Published: May 2021

According to DSC and EPR data kinetics of formation of simultaneous semi-interpenetrating polymer networks based on crosslinked polyurethane and linear polymethylmethacrylate with 50:50 and 70:30 ratio obtained in the presence of 3d-metal chelates depends on type of metal. On the other hand system composition determines polyurethane or polymethylmethacrylate selection during formation of complexes with metal -diketonates.