bluuebunny/crossref_metadata_2025 huggingface dataset:
Desenvolvimento e aplicação de nova metodologia de perfis de vento offshore
Authors: Rodrigues do Carmo Luiz Felipe , Pinto de Almeida Palmeira Ana Cristina , Ceccopieri Belo Wellington , Paiva Nunes Luis Manoel
Published: December 2023

O vento é uma importante variável de estudo. Isso porque é utilizado para muitas finalidades, além de, em casos extremos, provocar desastres naturais. Pelo ponto de vista energético, ele é um importante ente na geração de energia eólica e, portanto, sua correta estimativa torna-se essencial. Ainda sobre essa temática, a estimativa do perfil vertical de vento torna-se importante, já que os aerogeradores não se encontram em superfície, mas em níveis mais altos.  Dessa forma, o objetivo deste trabalho foi estudar os perfis de vento offshore utilizando as metodologias de estimativas calculadas no trabalho de Carmo et al. (2021) e compará-las a uma nova metodologia desenvolvida em função da temperatura da superfície do mar (TSM) e temperatura do ar (T). Para tal, foram utilizados os dados da Reanálise ERA5, dados da plataforma P25 e dados da boia localizada na plataforma P18 no período entre 1° de agosto de 1999 e 31 de agosto de 1999. Os resultados mostraram que o método desenvolvido apresentou bons resultados para a região de estudo e que a atmosfera apresentou classe de estabilidade neutra, com valores de Skill Score (SS) e Nash–Sutcliffe Efficiency (NSE) relativamente mais representativos do que o dos outros métodos estudados.  Comparativamente, a inserção da TSM e de T na estimativa dos perfis apresentou um ganho significativo na interpretação e precisão dos resultados.
Palavras-chave: Perfil de Vento; Energia; Temperatura.
New Forms of Genocide Documentaries: The Duel and the Quiet Interview
Authors: Morag Raya
Published: December 2023

This essay aims, first, to put forth two new forms of genocide documentaries: The Duel and the Quiet Interview (my terms). These forms emerged from two of the major non-Western catastrophes of twentieth-century Communism — the Cambodian autogenocide and the Chinese Maoist Revolution (respectively). In both the Duel and the Quiet Interview, the directors search for historical truth, which, in both societies, has been silenced, taboo-ized and censored for circa 40 years. Second, despite the obvious differences between their historical-traumatic-cultural contexts, and their addressees, I contend that both forms shed light on the failure of post-Holocaust Western paradigmatic literature – initiated most prominently by Felman and Laub (1992), Hilberg (1993), LaCapra (2001), Felman (2002) and Wieviorka (2006) - to recognize these non-Western catastrophes as an immanent part of the Age of Testimony. I further contend that both forms expand the ethical boundaries of trauma, trauma cinema studies and related fields of research. Finally, dealing with collaboration as an undertheorized subject position in the West, this essay calls for the constitution of collaboration studies alongside perpetrator studies.
Before, During, After: Difficulties and Controversies in Fieldwork with Retired Officers from the Argentine Army
Authors: Salvi Valentina
Published: December 2023

Between 2004 and 2007, I conducted fieldwork to analyze the memories and commemorative practices of retired officers of the Argentine Army, who were on active duty during the state terrorism executed by the armed forces during the military dictatorship (1976-1983) in Argentina. I conducted a series of open and semi-structured interviews with officers who participated in Operation Independence (Operativo Independencia) in Tucumán Province and made observations during public events in military churches and military clubs that paid tribute to officers who were assassinated by nonstate armed organizations during the 1970s. This ethnographic methodology has allowed me, first, to address the manifestations of the past as constructed, staged, and transmitted by the retired officers; second, to identify the meanings and values that these officers evoke to justify state terrorism; and third, how they constructed a retrospective relationship with violence and dealt with the criticisms they received from society. The aim of this article is to highlight the vicissitudes, difficulties, and controversies that framed my fieldwork with retired officers of the Argentine Army at three moments: before, when I was designing the methodology to delve into the military world; during, when I established contact and conducted the interviews with retired officers; and after, when I presented the results of my work on their memories to colleagues in academia. In sum, the article reflects on the conditions for the production of knowledge about perpetrators in Argentina. I explore the problems related to understanding the memories of the officers and interpreting their words: both what is said and what remains unsaid in the interviews, and how this can contribute to knowledge about processes of mass violence based on the memories of the perpetrators.
Распространение вариантов вируса SARS-COV-2, вызывающих интерес (VOI) и находящихся под наблюдением (VUM), на основе количества их геномов, депонированных в базу данных GISAID за неделю с 16 по 22 декабря 2023 г.
Authors: Дмитриева Людмила , Краснов Ярослав , Гусева Наталья , Чумачкова Елена , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: December 2023

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 Omicron вызывающих интерес (VOI) и находящихся под наблюдением (VUM), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 16 по 22 декабря 2023 г.
Traumatic Mid-substance Isolated Vastus Medialis Rupture in a Young Athlete
Authors: Elicegui Steven , Stovak Mark , Dobrich Jordan , Hodges Jonathan J. , Sekhon Vijay , Dolan Christopher
Published: December 2023

Update

This article was updated on January 25, 2024 because of a previous error. John Hodges, DPT should be listed as Jonathan J. Hodges, DPT.

An erratum (JBJS Case Connect. 2024;14[1]:e23.00422ER) has been published for this article.

Case:

This is the first documented case of an isolated traumatic vastus medialis rupture that occurred in a 14-year-old athlete after direct impact during play. Imaging confirmed a rare mid-substance rupture. The patient underwent conservative management with physical therapy augmented by blood flow restriction therapy (BFRT) and platelet-poor plasma (PPP) injection to regain full function.

Conclusion:

Isolated quadriceps mid-substance tears are rare. Determining an appropriate treatment technique for mid-substance tears is complex. This case documents the use of nonoperative management with BFRT and PPP to achieve full recovery and early return to play in a young athlete.
Identification of potential regional sources of ambient criteria air pollutants at a national controlled air quality observation site in Guiyang
Authors: Sun Haiyan , Yang Yuan , Xu Peng , Li Jinjuan , Cao Minxia , Wang Yonghong , Sheng Li , Zhang Fengming
Published: December 2023

Comprehensively characterising air pollutant cross-boundary transport is indispensable for determining effective control measures to further improve the air quality. Taking advantage of datasets of criteria pollutants (i.e., PM10, PM2.5, SO2, CO, NO, NO2, NOx and O3) and meteorological parameters, we comprehensively characterised the regional transport of air pollutants in Guiyang using bivariate polar plots (BPPs) and Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT-4), potential source contribution function (PSCF) and concentration-weighted trajectory (CWT) models. The average mass concentrations of PM10, PM2.5, SO2, CO, NO2 and O3 were lower than the CNAAQ Class I standards and were much lower than those in the key air pollution control regions for the Blue Sky Protection Campaign. Decreasing trends in PM10, PM2.5, SO2, NO, NO2 and NOx and an increasing trend in O3 were observed, confirming the effectiveness of air pollution control policies and suggesting that continuous and effective emission control measures should be implemented to further improve the air quality. The BPPs revealed that all pollutants, except O3, attained higher mass concentrations when wind speeds were low, and under the high-wind speed scenario, the dependence of the air pollutant concentrations on the wind speed and wind direction varied seasonally. The high-concentration backward trajectories and PSCF and CWT analysis results demonstrated that both tailored local emission reduction and regional cooperative control, which should be implemented when suitable, are crucial for controlling multiple pollutants and hence further improving the air quality in Guiyang in the upcoming years.
Error-mitigated fermionic classical shadows on noisy quantum devices
Authors: Wu Bujiao , Koh Dax
Published: December 2023

Efficiently estimating the expectation values of fermionic Hamiltonians, including $k$-particle reduced density matrices ($k$-RDMs) of an $n$-mode fermionic state, is crucial for quantum simulations of a wealth of physical systems from the fields of many-body physics, chemistry, and materials. Classical shadow (CS) algorithms have been proposed as a solution to address this task by substantially reducing the number of copies of quantum states. However, the implementation of these algorithms faces a significant challenge due to the inherent noise in near-term quantum devices, leading to inaccuracies in gate operations. To address this challenge, we propose an error-mitigated CS algorithm for fermionic systems. For $n$-qubit quantum systems, our algorithm, which employs the easily prepared initial state $|0^n\rangle\!\langle 0^n|$ assumed to be noiseless, provably efficiently estimates all elements of $k$-RDMs with $\widetilde{\mathcal O}(kn^k)$ scaled copies of quantum states and $\widetilde{\mathcal O}(\sqrt{n})$ scaled calibration measurements for the gate independent noise with constant average noise fidelities. The algorithm is robust against depolarizing, amplitude damping, and $X$-rotation noises with constant noise strength. Our algorithm exhibits scaling comparable to previous CS algorithms for fermionic systems with respect to the number of quantum state copies, while also demonstrating enhanced resilience to noise. We numerically demonstrate the performance of our algorithm in the presence of these noise sources. Our results underscore the potential utility of implementing our algorithm on near-term quantum devices.
A CB2 Agonist Alleviates Liver Fibrosis by Downregulating the ERK1/2 Signalling Pathway in Mouse Hepatic Fibrosis Model
Authors: He Ping , Wu Yafeng , Long Cuizhen , Shun Jianchao , Wang Yuping
Published: December 2023

Cannabinoid type 2 (CB2) receptors have been reported to display potent anti-fibrogenic properties in mice with carbon tetrachloride (CCL4)-induced hepatic fibrosis.However, the mechanism by which CB2 receptors inhibit fibrogenesis remains unclear. We aimed to study the effects of CB2 receptors in a mouse CCL4-induced hepatic fibrosis model. Hepatic fibrosis was induced by CCL4 administration in wild-type (WT) and CB2−/− mice. WT mice received vehicle, CCL4, AM1241 (CB2 receptor agonist) or AM1241 plus AM630 (CB2 receptor antagonist), with the AM1241 and AM1241 plus AM630 treatments injected intraperitoneally on each day of the 16-week CCL4 treatment. Real-time PCR and immunohistochemical staining were used to analyse α-smooth muscle actin (α-SMA) and profibrogenic marker (TGF-β1) expression and extracellular matrix (ECM) deposition (collagen-Ⅰ). HSC apoptosis were performed by TUNEL staining. Extracellular signal-regulated kinase (ERK1/2), cAMP response element-binding protein (CREB), Bcl-2, Bax and cleaved caspase-3 levels were characterized in mouse hepatic tissues via western blotting. Hepatic fibrosis was enhanced in CB2−/− mice compared to that in WT mice, and this phenomenon was alleviated in AM1241-treated WT mice. Moreover, the CB2 receptor agonist AM1241 decreased α-SMA, TGF-β1 and collagen-Ⅰ mRNA and protein expression and inhibited ERK1/2-CREB-Bcl-2 signalling pathway activity. Combined AM1241 and AM630 administration reversed the effects of AM1241. AM1241 inhibited hepatic stellate cell (HSC) activation, downregulated profibrogenic marker expression, decreased ECM deposition and alleviated fibrosis in WT mice. These effects were mediated at least in part by the induction of HSC apoptosis through ERK1/2-CREB-Bcl-2 downregulation. Thus, CB2 agonists are potential therapeutic agents for managing liver fibrosis.
Distinct patterns of corneal nerve fiber features in secondary parkinsonian patients vs idiopathic Parkinson’s disease
Authors: Che Ning-Ning , Jiang Qiu-Huan , Chen Shuai , Sun Zhi-Kun , Yang Wei-Min , Li Xue , Ma Jian-Jun , Zhang Jie-Wen , Malik Rayaz A , Yang Hong-Qi
Published: December 2023

As a neurodegenerative disease, PD involves both central and peripheral nervous systems, especially small nerve fibers damage. PD had progressive degeneration of dopaminergic neurons in the substantia nigra, and patients with secondary parkinsonism (SP) present with similar neurological symptoms, but without primary impairment of the nigrostriatal pathway. The results indicated that patients with SP showed no evidence of corneal nerve abnormality and 18F-DOPA PET, but patients with PD showed the opposite results, and ROC analysis showed combined corneal nerve parameters could increase the AUC to 0.907, indicating that corneal nerve loss may be a surrogate marker for distinguishing SP from PD.
Active Learning: EFL teachers’ Role in ELT Classrooms of Ebantu District Secondary Schools
Authors: Duresa Misgana
Published: December 2023

The study intended to investigate EFL teachers’ role in implementing active learning in ELT classrooms. The study used descriptive survey design with mixed method. Participants of the study were 15 EFL teachers and 5 students of Ebantu District high schools who were selected comprehensively and randomly respectively. The data obtained through questionnaire was entered into SPSS version-25 whereas students were interviewed individually. Mean and standard deviation were computed for the data collected through questionnaire and described in words whereas coding, categorizing and describing was used for interview. Besides, p-value was calculated using bivariate analysis. The result of the study revealed that active learning strategies were not used effectively in which teachers showed their role moderately. There was also insignificant relationship between teachers’ use of active learning strategies and the role they played. Therefore, teachers should understand the concept and varied types of active learning strategies to apply them effectively.
Maternal health disparities linked to stressful life events: A cross-sectional study of industrialized Italian cities
Authors: Bansal Esha , Patrono Alessandra , Renzetti Stefano , Lucchini Roberto G. , Chiu Yueh-Hsiu Mathilda , Conversano Michele , Montemurro Miriana , Bruno Deborah , Franco Carmen , Giorgino Augusto , Cagna Giuseppa , Fedrighi Chiara , Memo Maurizio , Placidi Donatella
Published: December 2023

Background
Understanding the impact of family life stressors on maternal health is crucial, particularly in highly industrialized areas. This study assessed the validity of an Italian-language version of the Crisis in Family Systems-Revised (CRISYS-R) survey in Northern and Southern Italian cohorts.
Methods
Mothers (n = 252) completed an Italian version of CRISYS-R, translated from English using the forward-backward method. At least 14 days after initial survey completion, a random subset of mothers (n = 44) retook CRISYS-R. Information about family demographics, socioeconomic status, and maternal health were collected by self-report on structured surveys. Statistical analyses were performed in R.
Results
Test-retest analysis yielded a Pearson coefficient of 0.714 (Brescia: 0.845, Taranto: 0.726). Cronbach’s alpha coefficient for internal consistency was 0.765 (Brescia: 0.718, Taranto: 0.784). In multivariable regression, the total number of stressors reported on the initial CRISYS-R test was positively associated with: poor maternal mental health (p < 0.001), poor maternal physical health (p < 0.01), and residence in the Southern rather than Northern Italy (p = 0.02). Univariate correlations yielded similar results, plus a negative correlation between annual family income and total life stressors (p < 0.05).
Conclusions
Statistical analyses support the validity and reliability of an Italian-language CRISYS-R in industrialized areas, while highlighting relationships between family stressors and maternal mental and physical health. This survey instrument has the potential to inform public health policies and interventions serving families in Italian-speaking areas with high burdens of industrial pollution.
POSoligo: in vitro gene synthesis oligonucleotide software
Authors: Tong Yingying , sun jie , Chen Yang , Yi Changhua , Yang Guanghua
Published: December 2023

Oligonucleotide synthesis is crucial for molecular experiments. Bioinformatics has been applied to develop various algorithm-based tools for the in vitro synthesis of nucleotides. The primary method of synthesizing long-chain DNA molecules involves connecting short-chain oligonucleotides through ligase chain reaction (LCR) and polymerase chain reaction (PCR). Short-chain DNA molecules exhibit low mutagenesis rates, while LCR requires complementary interfaces on both ends of the two nucleic acid molecules or might alter the conformation of nucleotide chain conformation, terminating amplification. Therefore, molecular melting temperature, length, and specificity should be considered during the experimental design.
Patch oligonucleotide synthesis (POS)oligo is a specialized offline tool for nucleotide fragment synthesis.. It optimizes the oligonucleotide length and specificity based on input single-stranded DNA, generating multiple contiguous long strands (COS) and short patch strands (POS) with complementary ends. This process ensures free 5′- and 3′-ends during oligonucleotide synthesis, preventing secondary structure formation and ensuring specific binding between COS and POS without stabilizing the complementary strands based on Tm values. POSoligo was used to synthesize the linear RBD sequence of SARS-CoV-2 using only one DNA strand, several POSs for LCR ligation, and two pairs of primers for PCR amplification in a time- and cost-effective manner.
RETRACTED: Disrupting the Genetic Code: The Impact of a novel homozygous/heterozygous Splicing Mutation on COL4A3 with mild phenotype in an autosomal recessive Alport Syndrome’s family
Authors: Chen Dan , Zhang Li , Rao Jing , Zhou Yan , Huang Songsong , Dai Lujun , Yang Chunxia , Bian Qiuhan , Zhang Tao , Yang Xiaoyan
Published: December 2023

The authors have requested that this preprint be removed from Research Square.
Impact of Population-Based Screening Programs on Colorectal Cancer Screening Uptake and Predictors in Atlantic Canada: A Repeated Cross-Sectional study
Authors: Adefemi Kazeem , Knight John C. , Zhu Yun , Wang Peter Peizhong
Published: December 2023

Background
Colorectal cancer (CRC) poses a significant public health challenge in Canada, with the Atlantic Provinces bearing a particularly high burden. The implementation of population-based colon screening programs is aimed to address this concern. However, limited research exists on the impact of these programs, including their uptake, barriers, and predictors of screening participation. This study aimed to examine impact of the first few years of the Colon Screening programs in the Atlantic Provinces of Canada by assessing changes in screening uptake, barriers, and predictors of screening among eligible population.
Methods
Employing a repeated cross-sectional design, this study selected and analysed data of a representative sample of respondents from the Atlantic provinces aged 50–74 years from the Canadian Community Health Survey (CCHS) for the years 2010 and 2017. The primary outcome measures were CRC screening rates and changes in predictors of screening uptake between these two data points. The CCHS data provided information on self-reported CRC screening participation and potential predictors such as age, sex, income, and education.
Results
Proportion of adults aged 50–74 years, up-to-date with CRC screening, increased, on average, from 42–54%, falling short of the national target of 60%. New Brunswick saw the biggest increase in screening prevalence (18%). Participation in the fecal tests increased significantly (19.7% − 32.4%). However, disparities in screening participation persist and, 41% and 50% of people with no screening history deemed the CRC fecal test and endoscopy tests unnecessary, respectively. Age, chronic health conditions, sex, marital status, regular healthcare access and smoking status remained significant predictors of CRC screening uptake.
Conclusions
This study highlights the need for continued efforts to improve CRC screening uptake in the Atlantic Provinces of Canada. Despite the establishment of screening programs, barriers to access and low awareness persist. Addressing these challenges and monitoring the impact of screening programs is essential to reduce CRC burden in the region and enhance public health outcomes.
Clinical features and prognostic biomarkers of patients with the rare SMACRA4 gene mutation in non-small cell lung cancer
Authors: LONG JINYU , Chen Ying , Luo Xingguang , rao ruiying , Wang Chenxi , Guo Yuxin , Xu Jinhe , Lin Ping , Song Yingfang , Qu Lijuan , Liu Qinghong , Lu Jun , Zhou Chengzhi , Song Zhengbo , Lin Xiandong , Yu Zongyang
Published: December 2023

Background:
Non-small cell lung cancer carrying SMARCA4 mutations is characterized by a high degree of malignancy and a poor prognosis. Due to the rarity of the population and the lack of a series of studies, the characteristics of the population with NSCLC and SMARCA4 mutations are not yet clear.
Methods:
The retrospective study collected data on 224 patients with tumors eligible for enrollment from December 2020 to July 2022. Among them, 26 developed SMARCA4 mutations, and 20 were eligible for inclusion in the specimen,with survival follow-up until April 2023. Clinical features, pathological characteristics, molecular features, and the role in the prognosis of SMARCA4 mutations were analyzed. The TCGA database was used to screen and obtain 481 NSCLC-SMARCA4-Mut samples for clinical characterization.
Results:
In TCGA, 283 patients with NSCLC-SMARCA4-Mut were ≥60-75 years old (58.84%), with a median age of 67 years. There were 312 males (64.86%) and 169 females (35.13%), with 374 smokers (77.75%). The origin sites of lung cancer were 277 (57.59%) in the upper lobe. Among the 20 clinical SMARCA4-Mut patients included, 12 (60%) were males and 8 (40%) were females, with a median age of 63 years. Through intergroup prognostic correlation analysis, the prognosis of SMARCA4-Mut patients was significantly worse than that of SMARCA4-Wt patients (P = 0.024). The positive expression of NapsinA was better in PFS1 and OS in SMARCA4-Mut (P = 0.016, P = 0.037). We used the ROC curve to predict PFS1 and OS of NapsinA in the Mut group with statistical significance (AUC = 0.829, P = 0.025, AUC = 0.814, P = 0.031).
Conclusion:
NSCLC-SMARCA4-Mut has a worse clinical prognosis. NapsinA-positive expression in SMARCA4-Mut patients was significantly associated with prolonged PFS1 and OS.
Sustainable lignocellulosic-based sponge with Janus salt-tolerant structure for efficient solar steam generation
Authors: Qiao Pengju , Yang Meng , Zhao Jinmin , Wang Zheng , Li Gang , Fang Jing , Qian Yong , Li Hao
Published: December 2023

Solar Vapor Generation (SVG) is a new green production technology that is gaining increasing attention for obtaining fresh water from seawater or wastewater. Currently, the evaporator substrates face challenges such as complex fabrication processes, high cost, and poor biodegradability. Lignocellulosic sponge (LS), as a sustainable material, exhibits characteristics such as hydrophilicity, excellent insulation properties, lightweight nature, and low cost. It is considered a highly promising material for evaporators. In this study, LS was modified to create an efficient evaporator with excellent salt resistance. The polyvinyl alcohol/carbon black (PVA/CB) gel-based photothermal coating was introduced to enhance the water evaporation rate significantly on the surface of the lignocellulosic sponge. Subsequently, a polydimethylsiloxane (PDMS) coating was sprayed on the interfacial steam generator surface to form a hydrophobic layer, effectively resisting salt accumulation on the evaporator surface. Simultaneously, the incorporation of degreased cotton as a one-dimensional water pathway enhanced the salt ion backflow and prevented salt crystallization at the hydrophilic/hydrophobic interface. The resulting porous sponge-based photothermal evaporator (PCP-LS) achieved a high evaporation rate of up to 3.2 kg m− 2h− 1 and demonstrated stable operation in high-concentration saltwater (20wt%). PCP-LS, as a cost-effective, easily fabricated, salt-tolerant, and environmentally friendly solar evaporator, holds great potential in seawater/wastewater treatment.
The Impacts of Smart City Construction on Carbon Total Factor Productivity: Empirical Evidence from China
Authors: Wu Zhongqi , Wang Xuliang
Published: December 2023

Today, low-carbon development and smart city pilots are prevalent. Against this backdrop, an urgent need exists to clarify the impact of smart city construction (SCC) on low-carbon development. However, studies on the low-carbon development effects of SCC remain scarce. Therefore, this in-depth study focuses on China, the world’s largest developing country, to examine the role of SCC in promoting low-carbon development. First, we calculate the carbon total factor productivity (CTFP) of 182 prefecture-level cities in China using the slacks-based global Malmquist–Luenberger index. Second, to empirically examine the impact of SCC on CTFP, we employ a multi-period difference-in-difference (DID) model and a machine learning–based propensity-score matching DID (PSM-DID) model. The results reveal that SCC significantly enhances CTFP and low-carbon technological efficiency, while its impact on low-carbon technological progress is nonsignificant. Mechanism tests indicate that SCC can improve CTFP through the following three channels: green technological innovation, industrial structure upgrading, and resource allocation. Heterogeneity tests indicate that all three batches of SCC improve CTFP, and that the positive effect of the third batch is greater than that of the first and second batches. Furthermore, the CTFP promotion effect of SCC is stronger in megacities and cities in the Central region. Finally, we propose relevant policy implications.
Post-COVID-19 Condition Symptoms Among Emergency Department Patients Tested for SARS-CoV-2 Infection
Authors: Archambault Patrick , Rosychuk Rhonda , Audet Martyne , Hau Jeffrey , Graves Lorraine , Décary Simon , Perry Jeffrey , Brooks Steven , Morrison Laurie , Daoust Raoul , Yeom David , Wiemer Hana , Fok Patrick , McRae Andrew , Chandra Kavish , Kho Michelle , Stacey Dawn , Vissandjée Bilkis , Menear Matthew , Mercier Eric , Vaillancourt Samuel , Aziz Samina , Zakaria Dianne , Davis Phil , Dainty Katie , Paquette Jean-Sébastien , Leeies Murdoch , Goulding Susie , Berger-Pelletier Elyse , Hohl Corinne
Published: December 2023

Importance: Symptoms of Post-COVID-19 Condition (PCC) are non-specific and can occur due to other medical conditions, making it a challenge to distinguish PCC from other health conditions.
Objective: To compare the proportion of emergency department (ED) patients who developed symptoms consistent with PCC between those who tested positive for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection and time-matched patients who tested negative.
Design: Observational cohort study that enrolled consecutive eligible patients between October 18, 2020, and February 28, 2022.
Setting: Thirty-three Canadian COVID-19 ED Rapid Response Network sites.
Participants: Eligible patients were aged ≥18 years and tested for SARS-CoV-2. We excluded patients not contacted after 5 attempts, unable to communicate due to language or cognitive barriers, deceased, or those who reported a subsequent positive test or symptomatic infection.
Exposure: SARS-CoV-2 infection.
Main outcome and Measure:Based on the World Health Organization (WHO) clinical case definition, our primary outcome was the proportion of ED patients reporting at least one new PCC-consistent symptom arising in the three months after the ED visit that was still present at the three-month mark and lasted >2 months.
Results: Of 29,838 individuals assessed for eligibility, 6,723 were included (58% SARS-CoV-2 positive; 51% female; mean age, 54.4 years [SD: 17.9]). Among 3,933 test-positive patients, 38.9% (1532/3933, 95% CI: 37.4-40.4%) reported PCC symptoms at 3 months compared to 20.7% (578/2790, 95% CI: 19.2-22.2%) of test-negative patients. Test-positive patients reported experiencing each individual PCC-consistent symptom at least twice as often as test-negative patients. The top three most frequently reported symptoms reported by test-positive patients were post-exertional malaise, dyspnea and memory problems. The most important predictor of subsequent PCC was a positive SARS-CoV-2 test during the index ED visit (adjusted OR=4.42).
Conclusions and Relevance: Over one-third of ED patients with a proven acute SARS-CoV-2 infection met PCC criteria at 3 months post-index ED visit, however one in five test-negative patients also reported PCC-consistent symptoms highlighting the lack of specificity of the WHO clinical case definition. Testing for SARS-CoV-2 during the acute phase of a suspected infection should continue until specific biomarkers of PCC become available for diagnosis and treatment referral.
Trial registration: Clinicaltrials.gov, no. NCT04702945
Examination of Tp-e interval, Tp-e / QT ratio, Tp-e / QTc ratio and fragmented QRS parameters in patients diagnosed with generalized anxiety disorder
Authors: Keles Fikret , keles denizhan danaci , yildiz sevler , kilicaslan asli kazgan , kurt osman
Published: December 2023

Objective
Anxiety disorders can be seen in individuals with cardiovascular disease, as well as cardiovascular diseases can be seen in individuals diagnosed with anxiety disorder. This situation can affect morbidity and mortality. In this respect, early diagnosis and treatment is very important. We aimed to recognize ventricular pro-arrhythmic conditions that may accompany generalized anxiety disorder (GAD) with electrocardiographic parameters.
Material-method:
50 patients diagnosed with generalized anxiety disorder for the first time and 50 healthy control groups were included in the study. Sociodemographic data form, Beck Anxiety Scale (BAI) and Beck Depression Scale (BDI) were applied to all participants. In addition, electrocardiography was performed in both groups and Tp-e interval, Tp-e / QT ratio, Tp-e / QTc ratio and fragmented QRS parameters were measured.
Results
It was observed that the anxiety and depression scores of the patient group were higher than the control group. (p < 0.001). In addition, it was found that the Tp-e interval, Tp-e / QT and Tp-e / QTc ratio were higher in individuals with GAD, and the rate of fragmented QRS in the patient group was significantly higher than the healthy control group. (p < 0.001) (p = 0.016). It was determined that there is a moderately positive significant relationship between BAI and BDI and Tp-e interval, Tp-e / QT ratio andTp-e / QTc ratio (r = 0.665, p < 0.001)
Conclusion
These findings show that ventricular repolarization and depolarization are affected in individuals with generalized anxiety disorder. This situation poses a risk in terms of arrhythmia and it would be appropriate to avoid pro-arrhythmic agents in drug selection in these patients. Since ECG is an inexpensive and easily accessible test, we think that cardiac follow-up of generalized anxiety disorders with ECG measurement may be beneficial.
Juri Elperin, 1917–2015
Authors: Stukalenko Viktoriya
Published: December 2023

Das Leben des russisch-deutschen Übersetzers Juri Elperin umfasst den Großteil des 20. Jahrhunderts und ist durch zahlreiche Grenzgänge zwischen den Kulturwelten geprägt. Mehr als fünfzig Jahre hat er der Literaturübersetzung gewidmet und ca. einhundert Werke russischer und sowjetischer Literatur ins Deutsche übersetzt. Diese Leistung ist besonders beachtenswert, da Elperin fast sein ganzes Berufsleben lang außerhalb des deutschen Sprachraums wohnte. In Davos geboren, in Berlin und Paris aufgewachsen, gehörte er zu den in der UdSSR lebenden Emigranten, die die russisch-sowjetische Literatur in ihre Muttersprache übertrugen.
Horst Engert, 1886–1949
Authors: Kelletat Andreas F. , Žvaliauskienė Sidona
Published: December 2023

Der Literaturwissenschaftler Horst Engert, der 1927 an die Universität in Kaunas berufen wurde, hat sich neben seiner germanistischen Lehre und Forschung mit dem Übersetzen zeitgenössischer litauischer Literatur beschäftigt. Dies ist als Pionierleistung zu bewerten, da auf Deutsch bis dahin nur Übersetzungen der traditionellen litauischen Volkspoesie sowie der im 18. Jahrhundert entstandenen "Jahreszeiten" von Donelaitis/Donalitius vorlagen.
El discurso de las familias canarias sobre la valoración y uso de los MDD en Educación Infantil
Authors: Fernández-Esteban María Inmaculada , Bethencourt-Aguilar Anabel , Becerra-Brito Cecilia Verónica , González González Miriam
Published: December 2023

Este artículo presenta la co-ocurrencia entre el uso de los materiales didácticos digitales (MDD) y la valoración de los recursos digitales, a partir de tres grupos de discusión en el que participaron un total de 16 personas con hijos e hijas en el 2º ciclo de educación infantil en la Comunidad Autónoma Canaria. Los códigos pertinentes a las categorías se obtuvieron de manera inductiva, para posteriormente ser observados por cuatro investigadoras de forma simultánea y finalmente fusionados, con el objetivo de obtener fiabilidad en el análisis de contenido realizado con el software Atlas.ti. Los resultados muestran una alta co-ocurrencia entre los códigos de estas categorías como los obtenidos entre los beneficios del uso de las TIC y la aceptación de la tecnología (1.57), los beneficios del uso de las TIC con la tecnología y juegos tradicionales (0.96), así como el uso didáctico de los recursos TIC educativos con la selección de estos materiales (0.68). Las conclusiones apuntan a una relación bidireccional en el tipo de uso que se hacen de los recursos digitales en los diferentes contextos, influenciando estrechamente la forma en la que se introducen estas tecnologías en los procesos educativos.
EBEVEYNLERİN OTİZM GÜNDÜZ BAKIM REHABİLİTASYON VE AİLE DANIŞMANLIĞI MERKEZLERİNDEN ALDIKLARI HİZMETLERE İLİŞKİN GÖRÜŞLERİNİN İNCELENMESİ
Authors: YAĞCIOĞLU Özlem , YILMAZ ATMAN Betül
Published: December 2023

Otizm spektrum bozukluğu (OSB) bireylerin iletişimi başlatma, devam ettirme gibi sosyal etkileşim alanlarında sınırlılıklara sebep olan bir nörogelişimsel bozukluktur. Çocukları OSB tanısı aldıktan sonra ebeveynlerin yaşamları değişmekte, çocuklarından bağımsız hareket etme, çocuklarına ve kendilerine ilişkin rehberlik edilmesi gibi konularda ebeveynler yardıma ihtiyaç duyabilmektedir. Bu duruma yönelik ebeveynler çeşitli hizmetler almaktadır. Ülkemizde OSB olan bireyler ve ailelerine hem destek eğitim sağlanmakta hem de ailelerin ihtiyaçlarına ilişkin bakanlıklarca yürütülen farklı hizmetler verilmektedir. Aile Sosyal Hizmetler Bakanlığı (ASHB) OSB olan birey ve ailelerine çeşitli hizmetler sağlayan kurumlardan biridir. ASHB tarafından yayımlanan Otizm Eylem Planı doğrultusunda yalnızca OSB olan bireyler ve ailelerine hizmet veren “Otizm Gündüz Bakım Rehabilitasyon ve Aile Danışma Merkezi” (OGBRADM) adıyla kurumlar açılmıştır. Henüz yeni açılan bu merkezlerde aile danışmanlığı ve gündüz bakımı gibi çeşitli hizmetler verilmektedir. Bu çalışmanın amacı, ebeveynlerin OSB olan çocuklarına yönelik OGBRADM’den aldıkları hizmetlere ilişkin görüşlerini incelemektir. Çalışmada nitel araştırma yöntemlerinden durum çalışması deseni kullanılmıştır. Araştırmada altı anne ve bir baba olmak üzere yedi katılımcı yer almış, elde edilen veriler betimsel analiz yoluyla analiz edilmiştir. Ebeveynlerin merkezlerden eğitsel, sosyal ve rehberlik hizmetleri aldıkları bu hizmetleri yararlı ancak sınırlı buldukları, geliştirilmesine yönelik öneriler sundukları tespit edilmiştir.
Caracterização Geoambiental do Litoral Oriental do Estado do Rio Grande do Norte, NE do Brasil
Authors: Dos Santos Chaves Marcelo , Maria Carvalho Lima Zuleide , Augusto Viana Varella Guilherme
Published: December 2023

O município de Baía Formosa está localizado no litoral Leste potiguar, no Estado do Rio Grande do Norte, integrantes de uma sequência de praias formando baías em forma de zeta. Esta pesquisa visa caracterizar os aspectos geoambientais da área em questão com um enfoque na análise sedimentológica, composta por análise granulométrica, teores de carbonato e de matéria orgânica, visto que não existem estudos de tal cunho para o local. A caracterização geoambiental aborda os aspectos geológicos, geomorfológicos, edáficos, climatológicos e socioeconômicos com enfoque em dados obtidos para o município de Baía Formosa/RN, que abriga os locais onde foram coletadas as doze (12) amostras para análise sedimentológica, sempre na faixa de praia do estirâncio que, por sua vez, demonstra notável uniformidade de areias de granulometria média, em sua maior parte de diâmetros entre 0.250mm e 0.350mm, fazendo jus à classificação de praia refletiva exposta, facilitando que sedimentos mais finos sejam removidos mais constantemente.  As análises de teor de carbonato e matéria orgânica seguem com certa uniformidade, porém as análises gráficas demonstram tendências ligeiramente diferenciadas entre os pontos de coleta, indicando diferentes tendências de curva, curtose e selecionamento dos sedimentos. O estudo poderá, além de complementar o conhecimento acerca da região, servir de ponto inicial de um possível monitoramento contínuo.
Modellalkotás középiskolás fokon
Authors: Kézi Csaba
Published: December 2023

On February 11, 2021, I gave a motivational lecture at the Tamás Esze High School in Mátészalka, and I completed a series of test tasks with the students. In this article, I looked for an answer to how students who are about to graduate approach to solving math problems. The main objective was to investigate whether they prefer to solve purely mathematical or application-oriented tasks, and in which one they achieve better results. In this paper, I analyze the results obtained.
Folyamatosan változva
Authors: Szuszik Dóra
Published: December 2023

Our built environment’s community-oriented spaces are rapidly becoming obsolete in response to current social, cultural and economic demands. The renovation project of the tímárház Szárító műhely in Debrecen presents a new potentional transformation model in the region with a focus on community-creating and cultural awareness. The incremental, cost-effective small-scale intervention and adaptive reuse of the building’s spaces provide an opportunity to preserve its values and swiftly respond to evolving needs. In order to validate the underlying principles of the interventions proposed in the plan, it will be compared to two similar-minded examples, the Művészeti Ellátó in Eger and Szabadkikötő in Pécs. The projects were examined through the processes occuring within their respective life cycles, as their transformations exhibit recurring patterns. The analyses were conducted based on interviews with the creators, online articles, studies and on-site visits.
The Necessity of Interoperability to Uncover the Full Potential of Digital Health Devices
Authors: Schwab Julian D , Werle Silke D , Hühne Rolf , Spohn Hannah , Kaisers Udo X , Kestler Hans A
Published: December 2023

Personalized health care can be optimized by including patient-reported outcomes. Standardized and disease-specific questionnaires have been developed and are routinely used. These patient-reported outcome questionnaires can be simple paper forms given to the patient to fill out with a pen or embedded in digital devices. Regardless of the format used, they provide a snapshot of the patient’s feelings and indicate when therapies need to be adjusted. The advantage of digitizing these questionnaires is that they can be automatically analyzed, and patients can be monitored independently of doctor visits. Although the questions of most clinical patient-reported outcome questionnaires follow defined standards and are evaluated by clinical trials, these standards do not exist for data processing. Interoperable data formats and structures would benefit multilingual and cross-study data exchange. Linking questionnaires to standardized terminologies such as the Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT) and Logical Observation Identifiers, Names, and Codes (LOINC) would improve this interoperability. However, linking clinically validated patient-reported outcome questionnaires to clinical terms available in SNOMED CT or LOINC is not as straightforward as it sounds. Here, we report our approach to link patient-reported outcomes from health applications to SNOMED CT or LOINC codes. We highlight current difficulties in this process and outline ways to minimize them.
The Impact of Intervention Design on User Engagement in Digital Therapeutics Research: Factorial Experiment With a Mixed Methods Study
Authors: Lee Hyerim , Choi Eung Ho , Shin Jung U , Kim Tae-Gyun , Oh Jooyoung , Shin Bokyoung , Sim Jung Yeon , Shin Jaeyong , Kim Meelim
Published: December 2023

Background

User engagement is crucial for digital therapeutics (DTx) effectiveness; due to variations in the conceptualization of engagement and intervention design, assessment and retention of engagement remain challenging.

Objective

We investigated the influence of the perceived acceptability of experimental intervention components and satisfaction with core intervention components in DTx on user engagement, while also identifying potential barriers and facilitators to user engagement.

Methods

We conducted a mixed methods study with a 2 × 2 factorial design, involving 12 outpatients with atopic dermatitis. Participants were randomized into 4 experimental groups based on push notification (“basic” or “advanced”) and human coach (“on” or “off”) experimental intervention components. All participants engaged in self-monitoring and learning courses as core intervention components within an app-based intervention over 8 weeks. Data were collected through in-app behavioral data, physician- and self-reported questionnaires, and semistructured interviews assessed at baseline, 4 weeks, and 8 weeks. Descriptive statistics and thematic analysis were used to evaluate user engagement, perceived acceptability of experimental intervention components (ie, push notification and human coach), satisfaction with core intervention components (ie, self-monitoring and learning courses), and intervention effectiveness through clinical outcomes.

Results

The primary outcome indicated that group 4, provided with “advanced-level push notifications” and a “human coach,” showed higher completion rates for self-monitoring forms and learning courses compared to the predetermined threshold of clinical significance. Qualitative data analysis revealed three key themes: (1) perceived acceptability of the experimental intervention components, (2) satisfaction with the core intervention components, and (3) suggestions for improvement in the overall intervention program. Regarding clinical outcomes, the Perceived Stress Scale and Dermatology Life Quality Index scores presented the highest improvement in group 4.

Conclusions

These findings will help refine the intervention and inform the design of a subsequent randomized trial to test its effectiveness. Furthermore, this design may serve as a model for broadly examining and optimizing overall engagement in DTx and for future investigation into the complex relationship between engagement and clinical outcomes.

Trial Registration

Clinical Research Information Service KCT0007675; http://tinyurl.com/2m8rjrmv
Discussions With End Users to Inform the Vision for a Shared Care Record in Ontario: Qualitative Interview Study
Authors: Chmielewski Marta , Meyer Matthew J
Published: December 2023

Background

Improving the health outcomes of populations of individuals through population health management requires the use of electronic health records that can exchange real-time digital information using an accurate and complete shared care record that is accessible to health care providers, services, and patients.

Objective

The aims of this study were to understand end users’ (health care providers) experiences, attitudes, and insights using current electronic health records; their expectations of what is required to establish a shared care record; and how they anticipate adapting to the use of a shared care record in daily practice. This work is the result of a quality improvement initiative deemed not to require ethics approval according to the Western research ethics board checklist.

Methods

Clinicians were contacted using voluntary response sampling and interviewed via Zoom (Zoom Video Communications) between June 2022 and July 2022. The participants were from various health care sectors and at various stages of career development.

Results

Overall, adaptation to the use of a shared care record was viewed positively by health care providers, highlighting the benefits of a centralized, shared, and accessible location for real-time data, promoting patient continuity of care. The main concerns included the privacy, confidentiality, and security of the record along with patients’ ability to interpret their own medical information found in a patient portal. The resources requested by end users included multifaceted ongoing training on the use of a shared care record.

Conclusions

This study provides practical findings that will help emphasize factors that facilitate clinicians’ practical use and process of adaptation to the use of a shared care record.
Psycho-emotional stress and its impact on the intestine before and after artificial abortion
Authors: Podolskyi Vl.V. , Podolskyy V.V. , Medvedovska N.V. , Botsyuk U.I. , Stovban І.V.
Published: December 2023

This study explores the psycho-emotional stress and related intestinal symptoms among women of fertile age who underwent an artificial abortion, utilizing a well-defined point-based questionnaire for stress levels and the revised version of the questionnaire for healthcare professionals to evaluate intestinal symptoms. The cohort consisted of 400 participants, with stress levels categorized as low (0–30 points), medium (31–70 points), or high (71+ points) according to the Perceived Stress Scale-10 (PSS). Further, perceived helplessness and perceived self-efficacy were evaluated via negative and positive PSS items, respectively. Findings indicated that most (65.5 %) women experienced high, and 27.5 % — medium stress before an abortion. Notably, pre-abortion stress levels were generally higher compared to those after an abortion. Concurrently, the frequency of bowel symptoms declined after an abortion. A significant relationship was found between pre-abortion bowel symptoms and higher post-abortion PSS scores, and an increase in the perceived helplessness subgroup (p = 0.051, R2 = 0.156; p = 0.029, R2 = 0.138, respectively). Furthermore, higher perceived helplessness scores were linked with increased pre-abortion intestinal symptoms (p = 0.043, R2 = 0.341). The study, however, found no significant correlations between bowel symptoms and the perceived self-efficacy subgroup. These results suggest an association between pre-abortion psychological factors (lower self-efficacy and higher stress levels) and the incidence of intestinal symptoms, thus shedding light on the intersection of psychological and physical well-being in reproductive health contexts. Further research is needed to explore these mechanisms and develop effective support strategies.