bluuebunny/crossref_metadata_2025 huggingface dataset:
Ortaokul Öğrencilerinin Fiziksel Aktivite Düzeyleri ile Fiziksel Aktiviteye Yönelik Motivasyonları Arasındaki İlişkinin İncelenmesi
Authors: ÇİFÇİ Ferhat , BALLIKAYA Ersin
Published: March 2023

Fiziksel hareketsizlik tüm yaş gruplarındaki insanların genel sağlığını olumsuz etkileyen küresel bir halk sağlığı sorunudur. Bu nedenle, Fiziksel aktivitenin ilişkili olduğu faktörlerin ortaya konulması önem taşımaktadır. Bu bağlamda araştırmanın amacı, Türk ortaokul öğrencilerinin FA düzeyleri ile FA’ya yönelik motivasyonları arasında olası ilişkiyi belirlemek ve cinsiyet, yaş değişkeni açısından farklılaşma durumunu incelemektir. Araştırmada ilişkisel tarama modeli kullanılmıştır. Araştırmaya 546 kız, 538 erkek olmak üzere 1084 ortaokul öğrencisi (x̄ yaş=12.23 + .981) katılmıştır. Veriler ‘Kişisel Bilgi Formu’, ‘Çocuk Fiziksel Aktivite Anketi’ ve ‘Çocuklar için Benlik Motivasyonu Envanteri’ kullanılarak toplanmıştır. Verilerin analizinde t testi, tek yönlü varyans analizi (ANOVA) ve pearson korelasyon analizi kullanılmıştır. Araştırma bulguları, cinsiyet açısından katılımcıların FA ve FA’ya yönelik motivasyon puanlarında önemli farklılık olduğu (p <.05) ve erkeklerin okul içi FA, okul dışı FA ve genel FA puanı ile FA’ya yönelik motivasyon puanının daha yüksek olduğunu göstermektedir. Katılımcıların yaşları açısından FA ve FA’ya yönelik motivasyon düzeyinde farklılıklar olduğunu ortaya koymuştur (p <.05). Ayrıca, FA’ya yönelik motivasyon puanı ile genel FA ve okul dışı FA puanı arasında orta düzeyde; okul içi FA arasında ise düşük düzeyde pozitif bir ilişki olduğu bulunmuştur (p <.05). Araştırma sonuçları, erkek katılımcıların FA ve FA’ya yönelik motivasyon düzeyinin daha yüksek olduğunu; yaş arttıkça FA düzeyi ve motivasyonun azaldığını ve FA düzeyi yükseldikçe FA’ya yönelik motivasyonunda da arttığını göstermektedir. Sonuç olarak, çocuk ve ergenlerde motivasyonun FA’nın önemli bir belirleyicisi olduğu söylenebilir.
Enchondroma Presenting with an Acutely Painful Hand
Authors: Jose Tom , Mathew Thomas , Iqbal Awais
Published: March 2023

Enchondromas are intramedullary cartilage neoplasms with benign imaging features that constitute approx. 90% of benign tumours in the hands.

We present a 25-year-old previously fit and well female patient with Enchondroma of the metacarpal bone with characteristic imaging and pathologic fracture to increase its awareness for early diagnosis and treatment.
Low body mass index is associated with poor treatment outcome following radiotherapy in esophageal squamous cell carcinoma
Authors: Lee Ji-young , Choi Yunseon
Published: March 2023

Purpose: We aimed to determine whether patients with esophageal cancer with a low baseline body mass index (BMI) have a poor prognosis following radiotherapy (RT).Materials and Methods: We retrospectively analyzed data from 50 patients with esophageal cancer to determine whether a low starting BMI (before RT) was associated with a poor outcome. All study participants were diagnosed with non-metastatic esophageal squamous cell carcinoma (SCC).Results: The number of patients at each T stage were as follows: 7 (14%) patients at T1, 18 (36%) at T2, 19 (38%) at T3, and 6 (12%) at T4. Based on BMI, 7 (14%) patients were defined as underweight. A low BMI was common in patients with T3/T4 stage esophageal cancer (7/43, p = 0.01). Overall, the 3-year progression-free survival (PFS) and overall survival (OS) rates were 26.3% and 69.2%, respectively. In univariate analysis, clinical factors associated with poor PFS included being underweight (BMI <18.5 kg/m2; p = 0.011) and a positive N status (p = 0.017). Univariate analysis also revealed that being underweight was associated with a decrease in OS (p = 0.003). However, being underweight was not an independent prognostic factor for PFS and OS. Conclusion: Patients with esophageal SCC with a low starting BMI (BMI <18.5 kg/m2) are more prone to have a negative survival outcome following RT than patients who are considered to be normal weight or overweight. For this reason, it is important that clinicians pay more attention to BMI when treating patients with esophageal SCC.
Éclairages sur la protection de l’eau en période de conflit armé : pour un renouvellement de l’approche juridique
Authors: Tagus Charlotte
Published: March 2023

À plus forte raison au regard du visage que prennent les conflits armés contemporains, les enjeux que pose la protection de l’eau en période de conflit armé (Peca) mettent en évidence le caractère lacunaire du droit international humanitaire (DIH) en la matière. Cet article en étudie les facteurs déterminants et, partant, la nécessité de renouveler l’approche juridique afférente. À la croisée du droit international des droits de l’homme et du droit international de l’eau, nous envisagerons la perspective d’une approche plus spécifique et intégrée du DIH, à la lumière du droit de la paix pertinent au renforcement de la protection de la ressource.
Entre tensions électriques et géopolitiques : les enjeux énergétiques et de ressources en Asie centrale au prisme du minage de cryptomonnaies
Authors: Estecahandy Hugo
Published: March 2023

Le minage de cryptomonnaies, activité numérique énergivore lorsqu’elle est déployée à l’échelle industrielle, qui consiste à utiliser de la puissance de calcul informatique pour sécuriser des réseaux financiers alternatifs, a été grandement développé en Asie centrale et notamment au Kazakhstan. La hausse de la consommation électrique engendrée par l’industrie serait, d’après les autorités locales, à l’origine de la crise énergétique traversée par la région. En étudiant les dynamiques géopolitiques qui ont entraîné le développement du minage au sein de cet espace, cet article met en lumière des enjeux d’énergie et de ressources intrinsèques à la région, menaçant la stabilité de ces pays interdépendants. Cette analyse met en avant que, si le développement du minage a effectivement pu contribuer à augmenter la consommation énergétique régionale, il a été facilité par une certaine corruption également responsable de la désuétude du réseau électrique partagé entre le Kazakhstan, l’Ouzbékistan et le Kirghizistan.
Changement climatique et crise énergétique : nouvelle donne pour le nucléaire civil mondial
Authors: Lewandowski Cédric
Published: March 2023

L’article propose un état des lieux de l’énergie nucléaire civile dans le monde et des enjeux géopolitiques associés. Deuxième source d’électricité bas carbone dans le monde, la première au sein de l’UE, elle constitue un atout majeur pour lutter contre le changement climatique. Elle contribue également, dans la durée, à la sécurité d’approvisionnement en électricité et au développement économique des pays qui l’utilisent. C’est à l’aune de ces différents critères que s’apprécie le « retour en grâce » du nucléaire observé dans plusieurs pays européens depuis 2020. La « diplomatie nucléaire » est dès lors plus active que jamais : alors que le barycentre du nouveau nucléaire est aujourd’hui en Russie et en Chine, les États-Unis sont très engagés pour retrouver leur leadership en soutenant massivement leur recherche et leur industrie nationale, notamment dans le domaine des petits réacteurs modulaires, et en développant leurs partenariats internationaux. Dans ce contexte, la réussite de la reprise de la grande aventure du nucléaire civil en France passe par un grand projet national autorisant une mobilisation humaine, industrielle et financière qui lui permettra de recouvrer sa vocation de puissance nucléaire.
De l’annexion de la Crimée en 2014 à l’invasion de l’Ukraine en 2022 : extension et application des normes européennes au Nord Stream 2
Authors: Ramdani Sami
Published: March 2023

En réaction au développement du Nord Stream 2, la Commission européenne a proposé d’amender la directive gaz en 2017. Dans un premier temps, nous resituons le processus ayant vu émerger cet amendement jusqu’à son adoption en 2019. Puis, nous analysons les multiples tentatives de Nord Stream 2 AG pour contourner l’application des normes européennes. Certaines de ces procédures ont été suspendues par l’invasion de l’Ukraine, d’autres sont toujours en cours. Enfin, nous concluons en constatant l’impact qu’a eu cet amendement. Cette évolution législative visant des objectifs stratégiques marque une nouvelle étape de l’usage géopolitique du droit par la Commission européenne.
Homogenization of nonlinear hyperbolic problem with a dynamical boundary condition
Authors: Mohammed Mogtaba
Published: March 2023

In this work, we look at homogenization results for nonlinear hyperbolic problem with a non-local boundary condition. We use the periodic unfolding method to obtain a homogenized nonlinear hyperbolic equation in a fixed domain. Due to the investigation's peculiarity, the unfolding technique must be developed with special attention, creating an unusual two-scale model. We note that the non-local boundary condition caused a damping on the homogenized model.
On $ \mathcal{A B C} $ coupled Langevin fractional differential equations constrained by Perov's fixed point in generalized Banach spaces
Authors: Boutiara Abdelatif , Matar Mohammed M. , Alzabut Jehad , Samei Mohammad Esmael , Khan Hasib
Published: March 2023

Nonlinear differential equations are widely used in everyday scientific and engineering dynamics. Problems involving differential equations of fractional order with initial and phase changes are often employed. Using a novel norm that is comfortable for fractional and non-singular differential equations containing Atangana-Baleanu-Caputo fractional derivatives, we examined a new class of initial values issues in this study. The Perov fixed point theorems that are utilized in generalized Banach spaces form the foundation for the new findings. Examples of the numerical analysis are provided in order to safeguard and effectively present the key findings.
Under nonlinear prey-harvesting, effect of strong Allee effect on the dynamics of a modified Leslie-Gower predator-prey model
Authors: Singh Manoj K. , Singh Brajesh K. , Poonam  , Cattani Carlo
Published: March 2023

In the present study, the effects of the strong Allee effect on the dynamics of the modified Leslie-Gower predator-prey model, in the presence of nonlinear prey-harvesting, have been investigated. In our findings, it is seen that the behaviors of the described mathematical model are positive and bounded for all future times. The conditions for the local stability and existence for various distinct equilibrium points have been determined. The present research concludes that system dynamics are vulnerable to initial conditions. In addition, the presence of several types of bifurcations (e.g., saddle-node bifurcation, Hopf bifurcation, Bogdanov-Takens bifurcation, homoclinic bifurcation) has been investigated. The first Lyapunov coefficient has been evaluated to study the stability of the limit cycle that results from Hopf bifurcation. The presence of a homoclinic loop has been demonstrated by numerical simulation. Finally, possible phase drawings and parametric figures have been depicted to validate the outcomes.
Twenty-First Century Immersion Technologies in Health Professions Pedagogy
Authors: Hayes Catherine
Published: March 2023

This encyclopedia entry provides insight into the justification of pedagogy in the context of extended reality (XR), which itself encompasses virtual reality (VR), augmented reality (AR), and mixed/hybrid reality (MR), and how all have evolved into an ongoing source of complex ambiguity over the last decade, which the COVID-19 pandemic only highlighted and radically exacerbated. Being able to understand and operationalize each in the context of health professions pedagogy and scholarship became a necessity, which few would now ever question but which still raises issues in relation to the practices of risk assessment and management in professional fields of practice such as medicine, nursing, midwifery, and allied health professions practice.
Accountancy for E-Business Enterprises Based on Cyber Security
Authors: Yang Yu , Yin Zecheng
Published: March 2023

E-businesses (EBEs) may commit legal offenses due to perpetrating cybercrime while doing the commercial activity. According to the findings, various obstacles might deter cybercrime throughout accounting. The study examined the present laws for accounting policy elements and determined those aspects that should be included in the administrative document for e-business enterprise accounting policies. E-businesses must avoid cyber-crime (CC), which has a detrimental influence on the company's brand and diminishes client loyalty to ensure their success. According to the study's findings, the use of information and control functions of accounting can help prevent cyber-crime in the bookkeeping system by increasing the content of individual internal rules. The authors intended to make online payments for EBE-CC as safe, easy, and fast as possible. However, the internet is known for making its users feel anonymous. E-commerce (EC) transactions are vulnerable to cybercrime, resulting in considerable money and personal information losses.
The Application of Multimedia and Deep Learning in the Integration of Professional and Innovative Education in Colleges
Authors: Xu Shilin
Published: March 2023

In this paper, the authors study the assessment of professional practice courses in the integrated education of specialization and innovation, and use the multimedia and deep learning technology to complete the action recognition of students in practice courses. Firstly, the skeletal features are extracted from multimedia video data by Openpose algorithm, which is used for subsequent classification while ensuring privacy; then the LSTM method is used to recognize typical motions in student practice, and the average recognition result exceeds 89%; finally, practical application tests are conducted for laboratory and office scenes, and the results illustrate that the proposed framework performs well in the tests with recognition rate exceeding 80%. The algorithm framework provides a new idea for the curriculum setting and evaluation method of professional practice education, and gives data guarantee for their integration and innovation education.
Innovation of the Teaching Mode of History Courses in Colleges and Universities Based on Digital Technology
Authors: Li Dianfeng , Jing Hongchang
Published: March 2023

There are some problems in the teaching reform of history majors in some colleges. Not only are there deviations in teaching level and teaching methods, but there are also limitations in the implementation of reform methods that meet the reform objectives, which are closely related to the reform methods of each college and the characteristics of history major itself. On the one hand, with the complete integration and application of information technology and communication technology, history teaching is facing the upgrade from information-based teaching to digital teaching. This paper selects the innovation of history teaching mode in colleges and universities based on digital technology as the research topic, summarizes the present situation of history teaching from the current situation of history education and the problems in the process of digitalization, and analyzes the significance of the innovation of history teaching mode.
Il Rinascimento nella Kunstwissenschaft intorno al Novecento
Authors: Costa Maria Teresa
Published: March 2023

Il saggio si inserisce nel dibattito sulla storiografia (dell'arte) e sulla periodizzazione, opponendo modelli lineari ed evolutivi a modelli anacronistici e discontinui. Questi ultimi vengono analizzati attraverso la Kunstwissenschaft, un nuovo approccio alla storia dell'arte, emerso alla fine dell'Ottocento, inizialmente nei paesi di lingua tedesca, in opposizione ai modelli storiografici tradizionali, anticipando pratiche attuali, come i Studi Visivi e Storia dell'Arte Globale. In particolare, questo contributo offre alcuni esempi di come la Kunstwissenschaft abbia riflettuto sui propri strumenti epistemici, confrontandosi con l'epoca in cui la storia dell'arte iniziava a riflettere sul proprio statuto, il Rinascimento.
Motivos religiosos do sedentarismo primitivo em Vico e das migrações dos indígenas Apapocúva-Guarani segundo Nimuendaju
Authors: Santos Vladimir Chaves dos
Published: March 2023

Este estudo comparativo visa chamar a atenção para a atualidade da filosofia da mitologia de Vico e pretende mostrar como o filósofo do século XVIII parte da concepção materialista da cultura dos povos, fundada na dimensão econômica da sobrevivência e da utilidade pessoal, para justificar justamente o contrário, recorrendo à explicação de que motivações imateriais e até mesmo contrárias e adversas à sobrevivência individual, espirituais e religiosas, estão no fundamento da sociedade e da economia dos povos em geral. Essa perspectiva de compreensão da cultura e da mitologia, que explora a tópica do heroísmo e da religião como fundamento da sociedade, pode ser reforçada pela obra do etnólogo e indigenista Curt Nimuendaju, que estudou a fundo diversas tribos de indígenas brasileiros, tendo sido adotado pelos Apapocúva-Guarani. Embora divergentes quanto à função e importância do sedentarismo e das migrações para a cultura dos povos, ambos os autores atribuem à religião o fundamento da explicação desses comportamentos.
Epidermal Growth Factor Receptor in Hepatic Endothelial Cells Suppresses MCP-1–Dependent Monocyte Recruitment in Diabetes
Authors: Zhang Xinyi , Ohayon-Steckel Lee , Coppin Emilie , Johny Ebin , Dasari Ankush , Florentin Jonathan , Vasamsetti Sathish , Dutta Partha
Published: March 2023

Insulin resistance is a compromised response to insulin in target tissues such as liver. Emerging evidence shows that vascular endothelial cells (ECs) are critical in mediating glucose metabolism. However, how liver ECs can regulate inflammation in the setting of insulin resistance is still unknown. Using genome-wide transcriptome analysis of ECs isolated from diabetic mice, we found enrichment of the genes involved in epidermal growth factor receptor (Egfr) signaling. In line with this, hepatic sinusoidal ECs in diabetic mice had elevated levels of Egfr expression. Interestingly, we found an increased number of hepatic myeloid cells, especially macrophages, and systemic glucose intolerance in Cdh5Cre/+Egfrfl/fl mice lacking Egfr in ECs compared with littermate control mice with type II diabetes. Egfr deficiency upregulated the expression of MCP-1 in hepatic sinusoidal ECs. This resulted in augmented monocyte recruitment and macrophage differentiation in Cdh5Cre/+Egfrfl/fl mice compared with littermate control mice as determined by a mouse model of parabiosis. Finally, MCP-1 neutralization and hepatic macrophage depletion in Cdh5Cre/+Egfrfl/fl mice resulted in a reduced number of hepatic macrophages and ameliorated glucose intolerance compared with the control groups. Collectively, these results demonstrate a protective endothelial Egfr signaling in reducing monocyte-mediated hepatic inflammation and glucose intolerance in type II diabetic mice.
Investigating Thymic Epithelial Cell Diversity Using Systems Biology
Authors: Chiu Honyin , Linsley Peter S , Ziegler Steven F
Published: March 2023

The thymus is an intricate organ consisting of a diverse population of thymic epithelial cells (TECs). Cortical and medullary TECs and their subpopulations have distinct roles in coordinating the development and selection of functionally competent and self-tolerant T cells. Recent advances made in technologies such as single-cell RNA sequencing have made it possible to investigate and resolve the heterogeneity in TECs. These findings have provided further understanding of the molecular mechanisms regulating TEC function and expression of tissue-restricted Ags. In this brief review, we focus on the newly characterized subsets of TECs and their diversity in relation to their functions in supporting T cell development. We also discuss recent discoveries in expression of self-antigens in the context of TEC development as well as the cellular and molecular changes occurring during embryonic development to thymic involution.
Three-Dimensional Human Bone Marrow Organoids for the Study and Application of Normal and Abnormal Hematoimmunopoiesis
Authors: de Janon Alejandro , Mantalaris Athanasios , Panoskaltsis Nicki
Published: March 2023

Hematoimmunopoiesis takes place in the adult human bone marrow (BM), which is composed of heterogeneous niches with complex architecture that enables tight regulation of homeostatic and stress responses. There is a paucity of representative culture systems that recapitulate the heterogeneous three-dimensional (3D) human BM microenvironment and that can endogenously produce soluble factors and extracellular matrix that deliver culture fidelity for the study of both normal and abnormal hematopoiesis. Native BM lymphoid populations are also poorly represented in current in vitro and in vivo models, creating challenges for the study and treatment of BM immunopathology. BM organoid models leverage normal 3D organ structure to recreate functional niche microenvironments. Our focus herein is to review the current state of the art in the use of 3D BM organoids, focusing on their capacities to recreate critical quality attributes of the in vivo BM microenvironment for the study of human normal and abnormal hematopoiesis.
Advancements in repetitive transcranial magnetic Stimulation for ischemic stroke rehabilitation
Authors: Li Yongfang , Wang Ji-Xian , Yang Guo-Yuan
Published: March 2023

Despite significant improvements in acute stroke management, numerous stroke patients continue to experience wide-ranging disabilities, posing a severe global healthcare problem. Effective neuro-rehabilitation is critical for reduction of disability and improvement of life quality after stroke. Rapid developments in several post-ischemic stroke rehabilitation techniques, including magnetic, ultrasonic, optogenetic and electronic modalities, have been achieved in recent years. Repetitive transcranial magnetic stimulation has shown promising therapeutic efficacy in ischemic stroke rehabilitation during the last two decades. This review provides a detailed summary of the development, safety and efficacy of transcranial magnetic stimulation devices, current experimental models and mechanisms of repetitive transcranial magnetic stimulation in the context of ischemic stroke rehabilitation.
Perspectives on rehabilitation, exercise and synaptogenesis after stroke
Authors: Dandu Chaitu , Li Fengwu , Ding Yuchuan
Published: March 2023

Strokes are a leading cause of death, persistent neurological deficits, and physical disability worldwide. Exercise-mediated adaptations are an emerging form of therapies that aim to attenuate the severity of post-stroke physical disability; however, there are uncertainties regarding how specific parameters, such as time to initiation and intensity of exercise, affect rehabilitation outcomes. At the cellular level, physical rehabilitation after stroke may enhance post-stroke gluconeogenesis to promote neuroplasticity over cellular damage via hypoxia-inducible factor-1α and exosomes. Furthermore, there is thought to be an optimal time for the initiation of exercise after a stroke, but there is disagreement and uncertainty about this optimal time. This paper discusses the pathophysiology of physical rehabilitation after stroke and reviews current studies on the effects of physical exercise on stroke rehabilitation and plasticity.
The Qualitative Study of Gender Bias in Medicine: The Cyclic Effect
Authors: Sharma Neeraj , Sharma Ananya , Sharma Chetna
Published: March 2023

ABSTRACT

Background:

The development of a medical workforce that enables universal access to safe, just, and equitable healthcare is hampered by gender-related inequality and disparity.

Aim:

Our goal in this study is to comprehend how gender prejudice has a cyclical impact that spreads from the fields of education and research to clinical practice.

Materials and Methods:

We conducted a qualitative study in which we collected information from faculty members and MBBS students through individual interviews. The transcripts of the interviews were analyzed thematically.

Results and Discussion:

The participants reported a culture that reinforces gendered standards in both education and clinical practice. There is a gender bias in mentoring, learning support, and reading materials offered to students, which often spills into clinical practice and impacts how healthcare is delivered.

Conclusion:

According to our research, there is a cyclic effect of women’s exclusion in medical education, research, and clinical practice that is caused by gender bias. These results highlight the need for gender-just systems of education, research, and clinical care to successfully address gender prejudice.
Aortic Stenosis Detection Using Spectral Statistical Features of Heart Sound Signals
Authors: Kumar S. V. Mahesh , Dhinakar P. , Nishanth R.
Published: March 2023

INTRODUCTION: Aortic stenosis (AS) is a severe complicated heart valve disease. This valve abnormality is a slow-progressive condition and mostly asymptomatic. Hence, there is a need for a rapid non-invasive diagnosis method with minimal feature extraction.OBJECTIVE: In this paper, we proposed a spectral features-based rapid heart sound signal analysis method to identify the AS stages with minimum number of features.METHODS: In this study, the heart sound signals were collected from the medical database and transformed into the frequency domain for further spectral feature analysis. We used the windowing technique to conditioning the heart signals before spectral analysis. The spectral statistical features were extracted from the computed frequency spectrum. The range of statistical features was compared for normal, early, and AS sound signals.RESULTS: In experiments, the normal, early, and delayed AS heart sound signals were used. The normal/unhealthy condition of a heart was identified using the statistical features of the frequency spectrum. The experimental results show the statistical difference between the normal and AS heart sound signal spectrums.CONCLUSION: The experimental results confirmed that the statistical features derived from the heart sound signal spectrums were varied according to the AS condition. Hence, the spectral statistical features can be considered as rapid predictors of AS.
Disease burden of prostate cancer from 2014 to 2019 in the United States: estimation from the Global Burden of Disease Study 2019 and Medical Expenditure Panel Survey
Authors: Lin Shen , Lin Dong , Li Yiyuan , Zhong Lixian , Zhou Wei , Wu Yajing , Xie Chen , Luo Shaohong , Huang Xiaoting , Xu Xiongwei , Weng Xiuhua
Published: March 2023

OBJECTIVES: The aim of this study was to evaluate the disease burden of prostate cancer (PC) and assess key influencing factors associated with the disease expenditures of PC in the United States.METHODS: The total deaths, incidence, prevalence, and disability-adjusted life-years of PC were obtained from the Global Burden of Disease Study 2019. The Medical Expenditure Panel Survey was used to estimate healthcare expenditures and productivity loss and to investigate patterns of payment and use of healthcare resources in the United States. A multivariable logistic regression model was conducted to identify key factors influencing expenditures.RESULTS: For patients aged 50 and older, the burden for all age groups showed a modest increase over the 6-year period. Annual medical expenditures were estimated to range from US$24.8 billion to US$39.2 billion from 2014 to 2019. The annual loss in productivity for patients was approximately US$1,200. The top 3 major components of medical costs were hospital inpatient stays, prescription medicines, and office-based visits. Medicare was the largest source of payments for survivors. In terms of drug consumption, genitourinary tract agents (57.0%) and antineoplastics (18.6%) were the main therapeutic drugs. High medical expenditures were positively associated with age (p=0.005), having private health insurance (p=0.016), more comorbidities, not currently smoking (p=0.001), and patient self-perception of fair/poor health status (p<0.001).CONCLUSIONS: From 2014 to 2019, the national real-world data of PC revealed that the disease burden in the United States continued to increase, which was partly related to patient characteristics.
No association between genetically predicted C-reactive protein levels and colorectal cancer survival in Korean: two-sample Mendelian randomization analysis
Authors: Choi Chang Kyun , Yang Jung-Ho , Shin Min-Ho , Cho Sang-Hee , Kweon Sun-Seog
Published: March 2023

OBJECTIVES: Elevated C-reactive protein (CRP) levels are associated with an increased risk for colorectal cancer (CRC), as well as a poor prognosis, but it remains unclear whether these associations are causal. This study examined the potential causality between CRP levels and CRC survival using 2-sample Mendelian randomization (MR).METHODS: From the Korean Genome and Epidemiology Study, a genome-wide association study (n=59,605), 7 single-nucleotide polymorphisms (SNPs) related to log2-transformed CRP levels were extracted as instrumental variables for CRP levels. The associations between the genetically predicted CRP and CRC-specific and overall mortality among CRC patients (n=6,460) were evaluated by Aalen’s additive hazard model. The sensitivity analysis excluded a SNP related to the blood lipid profile.RESULTS: During a median of 8.5 years of follow-up, among 6,460 CRC patients, 2,676 (41.4%) CRC patients died from all causes and 1,622 (25.1%) died from CRC. Genetically predicted CRP levels were not significantly associated with overall or CRC-specific mortality in CRC patients. The hazard difference per 1,000 person-years for overall and CRC-specific mortality per 2-fold increase in CRP levels was -2.92 (95% confidence interval [CI], -14.05 to 8.21) and -0.76 (95% CI, -9.61 to 8.08), respectively. These associations were consistent in a subgroup analysis according to metastasis and a sensitivity analysis excluding possible pleiotropic SNPs.CONCLUSIONS: Our findings do not support a causal role for genetically predisposed CRP levels in CRC survival.
Confined Blood Chimerism in Monochorionic Diamniotic Dizygotic Twin
Authors: Kim Do-Hoon
Published: March 2023

Monochorionic diamniotic dizygotic (MCDADZ) twins are extremely rare. However, MCDADZ cases have been reported as in vitro fertilization-embryotransfer has become more common and genetic tests have become possible. In MCDADZ twin, vascular anastomosis occurs by sharing the placenta, then twin-twin transfusion syndrome or the confusion in blood typing or genetic test due to blood chimerism can occur. Authors report a case of MCDADZ twin who showed blood chimerism detected by karyotyping and chromosome microarray. They were born through in vitro fertilization, and confined blood chimerism was diagnosed by additional short tandem repeat study. Although there was no twin-twin transfusion syndrome or disconcordant blood-typing in our twins, genetic counseling and long-term follow up is needed for possible confusion in laboratory test due to persistent blood chimerism in the future.
Der erzählte Antisemitismus: Das Narrativ der Jüdischen Weltverschwörung von seinen literarischen Ursprüngen bis heute
Authors: Timm Julian
Published: March 2023

Antisemitische Narrative sind alt und aktuell zugleich – und machen auch vor Kinderbuchklassikern nicht halt. Lange Zeit haben Forschung und öffentlicher Diskurs die Vorstellung von einer Jüdischen Weltverschwörung an der vermeintlichen Glaubwürdigkeit der sogenannten »Protokolle der Weisen von Zion« festgemacht. Dabei ist bekannt, dass auch die gefälschten »Protokolle« auf ältere Texte zurückgehen. Einer dieser Texte ist John Retcliffes »Auf dem Judenkirchhof in Prag« (1868), in dem sich – anders als in den »Protokollen« – fiktive Elemente ausmachen lassen, die bis heute die Vorstellung von einer Jüdischen Weltverschwörung konstituieren. Aus literaturwissenschaftlicher Perspektive zeigt Julian Timm die Kontinuitäten des Narrativs der »Jüdischen Weltverschwörung« von seinen literarischen Anfängen im 19. Jahrhundert über Michael Endes »Wunschpunsch« (1989) bis zu Umberto Ecos »Der Friedhof in Prag« (2010) und stellt dar, wie bis heute antisemitische Fiktionen – bewusst oder unbewusst und über die Literatur hinaus – reproduziert werden und ein vormals literarisches Narrativ in verschwörungsaffinen Kreisen wiederholt zur Legitimationserzählung für antisemitische und rassistische Gewalttaten wie in Halle oder Hanau werden kann.
AS PERCEPÇÕES DE GÊNERO, O ACOLHIMENTO INSTITUCIONAL DE CRIANÇAS E O SERVIÇO SOCIAL
Authors: Petroski Machado Gabriele , Rolim de Moura Reidy
Published: March 2023

A desigualdade de gênero é um elemento que deve ser considerada ao deparar-se com a realidade das crianças acolhidas institucionalmente no que tange o contexto familiar dessas crianças e os papéis sociais do homem e da mulher na família.  Trata-se de um estudo qualitativo de natureza descritiva e exploratória, construído a partir da pesquisa bibliográfica, revisão documental e das vivências de uma estagiária de serviço social na Vara da Infância e Juventude de Ponta Grossa e pesquisadora da temática de gênero. Este artigo é fruto da pesquisa realizada para o Trabalho de Conclusão de Curso de umas das autoras e tem como principal objetivo apresentar de que forma se expressam as questões de gênero no processo de acolhimento institucional de crianças no município de Ponta Grossa/PR. Os principais resultados obtidos demonstraram que a condição de gênero está relacionado com os motivadores geradores do acolhimento institucional da crianças, ainda que não explicitamente, porém os dados demonstram que a desigualdade de gênero está presente neste processo. A sobrecarga da mulher nos cuidados domésticos e dos filhos é um fator que chama atenção para este processo, além do histórico familiar que reflete a repetição da violência nas famílias, mulheres que também viveram o abandono, negligências e violências em suas infâncias, acabam reproduzindo com seus filhos e diante desta realidade se reconhece a importância da atuação do serviço social no combate à violação dos direitos das crianças e também das mulheres e promover ações e serviços que atendam as demandas das garantias dos direitos.
NASILJE U ADOLESCENTSKIM PARTNERSKIM VEZAMA
Authors: Janković Ivana
Published: March 2023

Adolescencija je razvojni period u kome se uspostavljaju prve romantične veze i stiču prva romantična iskustva. Otuda je ovo vrlo osetljiv period i u razvojnom smislu veoma značajan za kreiranje slike zdravog i kvalitetnog partnerskog odnosa, za usvajanje veština i stavova da se takve veze održe, a prekinu one koje to nisu. Partnerske veze mogu se razumeti kao vrsta svojevoljnih interakcija koje se uspostavljaju između dvoje ljudi s ciljem zadovoljavanja različitih potreba, kao što su potreba za bliskošću, intimnošću, ljubavlju, prihvatanjem. Takođe, partnerski odnos trebalo bi da bude i kontekst u kome će se partneri osećati sigurno, zaštićeno i slobodno u pogledu iskazivanja svojih potreba, kontekst u kome je moguće ostvarivanje svih ličnih prava i sloboda. Nažalost, svedoci smo da u mnogim slučajevima to nije tako. Nekada, partnerski odnosi mogu biti izvor patnji, nezadovoljstva, uznemirenosti, što je i slučaj kada se doživljava nasilje u partnerskim vezama. Problemu nasilja u adolescentskim partnerskim vezama u ovoj monografiji pristupićemo iz više uglova. Najpre, uvodni deo monografije biće posvećen sagledavanju karakteristika partnerskih veza u ovom razvojnom periodu i konflikata kao oblika interakcija između partnera koji ne mora nužno biti nasilan. Ipak, u zavisnosti od načina na koji partneri razrešavaju konflikte, njihovi partnerski odnosi mogu postati nasilni. Nadalje ćemo se upoznati sa značenjem partnerskog nasilja, karakteristikama određenih oblika nasilja i njihovom prevalencijom na ovom uzrastu. Moguća objašnjena partnerskog nasilja potražićemo u teorijama koje nude različita razumevanja nastanka i održavanja nasilja u partnerskim vezama. Iz ugla ekološkog teorijskog modela pokušaćemo da definišemo riziko i protektivne faktore kako za doživljavanje tako i za počinjenje nasilja u partnerskim vezama. Destruktivnost nasilja sagledaćemo kroz moguće posledice do kojih nasije može dovesti u domenu fizičkog i mentalnog zdravlja i kroz ispoljavanje rizičnih oblika ponašanja. Kako bismo razumeli moguće načine prevencije nasilja u adolescentskim partnerskim vezama, biće predstavljeni i analizirani neki od postojećih programa prevencije nasilja. Poseban deo biće posvećen razumevanju digitalnog partnerskog nasilja i njegovog odnosa sa nasiljem koje se sprovodi u realnom, oflajn prostoru.
MODULATION OF NEGATIVELY CHARGED PARTICLE FLUX FROM PENNING DISCHARGE WITH METAL HYDRIDE CATHODE
Authors: Sereda I. , Hrechko Ya. , Azarenkov M.
Published: March 2023

The features of modulation of negatively charged particle flux extracted along the magnetic field from Penning discharge with metal hydride cathode have been investigated. The separation of negative ions from coextracted electrons was performed by an electromagnetic filter with efficiency not worse than 90 %. It is shown that electrons
in the extracted flow are deeply modulated with the frequency of the diocotron instability of the anode layer, while negative ions are not. An increase in the interelectrode distance and anode length resulted in a more pronounced expression of this effect due to the minimization of the influence of the magnetic field of the filter on the discharge.
INVESTIGATION OF THERMAL PLASMA OF ARC DISCHARGE BETWEEN NOVEL COMPOSITE Cu-W MATERIALS
Authors: Murmantsev A. , Veklich A. , Boretskij V. , Fesenko S. , Kleshych M. , Tolochin O.
Published: March 2023

In this work, the plasma emission of electric arc discharges between pairs of composite Cu-W electrodes was investigated by optical emission spectroscopy. Electrodes manufactured of Cu-W 50 vol.% composite materials by shock sintering technology at temperatures of 750, 850, 950, and 1050°C were used. The radial distributions of plasma temperature were determined by Boltzmann plot technique on the basis of the absolute values of intensity of both copper and tungsten spectral lines. The concentration of metal atoms of electrode origin (copper and tungsten) in the positive plasma column of electric arc discharges between studied electrodes manufactured of composite Cu-W materials was determined by the method of absolute intensities. The intensity of erosion of individual components of composite materials is estimated in an indirect way by comparing the radial distributions of atoms of materials of electrode origin for each type of the investigated arc discharge.
Penegakan Hukum Hak Cipta Terhadap Download Film Pada Situs Ilegal
Authors: Hahury Arixellis Juan Efraim , Narwadan Theresia Nolda Agnes , Labetubun Muchtar Anshary Hamid
Published: March 2023

Introduction: Copyright is the exclusive right of the creator that arises automatically based on declarative principles after a work is realized in a tangible form, without reducing restrictions in accordance with the provisions of laws and regulations. Copyright has been protected by Law Number 28 of 2014. But in reality, there are still many copyright violations such as downloading movies on sites on illegal sites.Purposes of the Research: This study aims to determine Copyright Law Enforcement Against Downloading Films on Illegal Sites. Methods of the Research: The type of research used in this thesis is the type of empirical research. The data collection method used is the method of observation, interviews and literature then the data obtained were analyzed descriptively qualitatively so as to reveal the expected results and conclusions on the problem.Results of the Research: The results of the study show that the enforcement of copyright law on downloading films on illegal sites has not been carried out in accordance with applicable law. This is based on the fact that copyright law enforcement is influenced by several factors, namely legal factors, law enforcement, infrastructure, society and culture. Legal factors, in this case the Law, have contained regulations related to copyright, but law enforcement factors have not been effective in carrying out their duties. In addition, the infrastructure factor in this case is related to the lack of support for communication facilities which is an obstacle related to reporting copyright infringement. Then the community factor and cultural factor, in this case the community still commits violations related to film copyright.
Perlindungan Hukum Terhadap Anak Korban Kekerasan yang dilakukan oleh Orang Tua Wali
Authors: Retraubun Jeheskel , Adam Sherly , Tuhumury Carolina
Published: March 2023

Introduction: A child is vulnerable to being a victim of abuse. The perpetrator could be the closest person, it is even possible that the child's parents themselves.Purposes of the Research: The purpose of this paper is to analyze and discuss the regulation of the rights of children victims of violence in the care of their parents guardians in the law as well as to analyze and discuss forms of special protection for children victims of violence by their parents. Methods of the Research: The type of research used is a normative legal research type (juridical normative), the problem approach used in this paper is a statutory approach (statute approach), concept analysis approach (analytical approach) and case approach (case approach). The materials used are primary legal materials and secondary legal materials. The collection of legal materials carried out in this study was carried out through library research, then analyzed using qualitative methods.Results of the Research: The regulation of legal protection for children victims of violence in the care of parents guardians in the law where the law of protection of children victims of violence committed. Forms of legal protection for children who are victims of violence carried out by parents and guardians provided by the government are coaching, mentoring, and social, health, physical and mental recovery. Then the form of special protection provided by the community and parents is to provide facilities and infrastructure, create a conducive atmosphere for children's growth and development, and nurture, nurture, educate and protect children.
Manfaat Pemidanaan Dalam Penanggulangan Tindak Pidana Narkotika
Authors: Lilipory Milton , Pasalbessy John Dirk , Lewerissa Yanti Amelia
Published: March 2023

Introduction: The criminalization of narcotics offenders is often subject to heavy penalties, but for potential perpetrators there is no deterrent effect, even recidivist or repeat offenders never feel deterred. Therefore, it is necessary to find alternative solutions to narcotics abuse more effectively so that it can have a deterrent effect on both the perpetrators and potential perpetrators.Purposes of the Research: The purpose of this study is to analyze and explain the meaning and purpose of imposing criminal sanctions against narcotics abuse, so that the perpetrators or potential perpetrators become deterrent, as well as to discuss the purpose of imposing heavy penalties for perpetrators of drug abuse in terms of the theories of the purpose of punishment that have been adopted in the development of criminal law. Methods of the Research: The method used in this study is a normative juridical method with a statutory approach, a conceptual approach and a case approach. The legal materials used are library law materials. Thus, the legal materials studied and analyzed in normative legal research consist of primary legal materials, such as legislation, secondary legal materials in the form of legal literature, consisting of books, scientific journals, legal documents and so on, as well as legal materials. tertiary in the form of legal dictionaries, encyclopedias and so on.Results of the Research: Based on the results of the study, it is shown that the imposition of serious crimes against narcotics traffickers is not always able to solve the problem of lawbreakers, both seen from the theories of classical criminal law, modern criminal law and new classical criminal law. This is reasonable because the prevention of crime lies not only in the model or duration of the punishment given and served later, but on the criminal system adopted in a country that it adheres to. The problem of whether or not a person is deterred is not determined by how much sanctions are given, because the provision of sanctions and whether or not a person is deterred depends on the attitude of people and society towards the crime he feels.
Kajian Yuridis Terhadap Transaksi Jual Beli Online Dengan Menggunakan Fitur Paylater
Authors: Hijriyanti Hijriyanti , Berlianty Teng , Kuahaty Sarah Selfina
Published: March 2023

Introduction: Shopee Paylater is a payment method which means users or consumers will get loans instantly. Each agreement of the parties has an obligation to fulfill achievements to other parties, in practice some of the Consumers do not carry out their obligations properly and correctly, some of the Consumers are not in good faith when carrying out product or service transactions, there are also buyers who do not pay in accordance with the agreed maturity date, therefore the Consumer is deemed to have defaulted.Purposes of the Research: Analyze and review the dispute resolution process if the consumer defaults on the Shopee Paylate payment method. Methods of the Research: : This research is included in normative legal research, namely research examining various positive legal provisions, various legal principles, legal principles and doctrines to answer legal issues faced by.Results of the Research: The results of the study show that the The procedure for carrying out online buying and selling transactions through Shopee using the Paylater feature can be done with the payment method in cash or installments. Furthermore, the process of resolving consumer disputes who default on paylater on the shopee marketplace is by paying a fine of 5% of the total bill and will continue to increase if it is not paid, consumers cannot checkout through shopee and the existing shopee paylater limit will be reduced because of this. the. does not carry out dispute resolution methods through litigation or non-litigation, the Shopee Paylater organizer only takes steps to resolve the dispute internally and provides administrative sanctions for defaulters on the Shopee Paylater usage agreement.
ЭТНИК ВА МИЛЛИЙ УРФ-ОДАТЛАР ҲАМДА ҚАДРИЯТЛАР АСОСИДА ШАКЛЛАНГАН ЖОЙ НОМЛАРИ
Authors: Абдуллаев Акмал
Published: March 2023

Ушбу мақолада Тошкент воҳасининг Оҳангарон, Паркент, Бўстонлиқ, Қибрай туманлари ҳамда Чирчиқ шаҳридаги халқ этник ва миллий урф-одатлари ҳамда қадриятлари асосида шаклланган жой номлари ҳақида маълумотлар берилган. Мазкур жой номларининг пайдо бўлишининг халқона ва илмий этимологияси ҳақида фикр-мулоҳазалар баён этилган.
NATIONAL EXPERIENCE IN THE DEVELOPMENT OF INFORMATION CONSUMPTION IN PUBLIC SERVICES: PROBLEMS AND SOLUTIONS
Authors: Yunusov Mansur
Published: March 2023

This article highlights the national experience in the development of information consumption in public services: problems and solutions, increasing information literacy, problems and achievements of media education, media literacy culture of public servants in public civil service
ИННОВАЦИОН ЁНДАШУВ АСОСИДА ТЕХНИКА ОЛИЙ ЎҚУВ ЮРТИ ТАЛАБАЛАРИНИ КАСБИЙ ФАОЛИЯТГА ТАЙЁРЛАШ
Authors: Явкочдиева Дилафруз
Published: March 2023

Ушбу мақолада инновацион ёндашув асосида техника олий ўқув юрти талабаларини касбий фаолиятга тайёрлаш методикаси тўғрисида ёритилган бўлиб, муаллиф томонидан муаллифлик патентига эга бўлган “Стаате” ва “Креатор” инновацион технологияларини техника олий ўқув юртларида мутахассислар тайёрлаш жараёнида ўқув фаолиятига қўллашга йўналтирилган усуллар ҳақида батафсил маълумот берилган.
THE USE OF REALTIME PCR IN THE MONITORING OF PATHOLOGY OF PIGS CAUSED BY THE CIRCOVIRUS OF THE SECOND TYPE
Authors: Krasnikova E. L. , Sadovsky A. L.
Published: March 2023

The article presents data on the persistence of type 2 circovirus in one of the farms of the Republic of Belarus. The presence of the pathogen genome in pigs of different ages was established, and comparative data on the results of PCR and ELISA were presented.