bluuebunny/crossref_metadata_2025 huggingface dataset:
FINANCING AND INSTITUTIONAL MODELS OF SOY PRODUCTS
Authors: Zainuri Zainuri , Hisamuddin Nur , Mahardiyanto Agus
Published: September 2019

Discourse on the development of soybean processed products is important to study because besides being able to uncover the question related to the low productivity of soybean cultivation also gives a clue as to why soybean processed product entrepreneurs have almost no accumulation of capital so far. This study aims to reveal financing models and institutional patterns of soybean processing businesses in Jember district. This type of research will use qualitative research from an emic perspective that will be implemented in the area of ​​Jember Regency. The type of data used is primary and secondary data which are then processed and analyzed using the Miles and Huberman analysis method. This study found that the development of soybean processing business, which consisted mainly of MSME entrepreneurs, was enticed by a financing model whose funds were mostly supplied by the Suwek Daily Bank (BHS) and loan sharks that caused the profit margins to not be enjoyed by the entrepreneurs themselves. In addition, the institutional patterns built between soybean processed products entrepreneurs such as tempeh, tofu, milk and soybean snacks are still weak. They individually compete more freely so that when there is a shock such as an increase in the price of imported or local soybeans it will sacrifice quality. Some build a vertical partnership pattern between soybean processed product entrepreneurs and their raw material suppliers and with soybean processed users, while horizontally between processed product entrepreneurs barely build partnerships. This condition causes unfair competition between businesses and ultimately increases the transactions cost of economic that will erode the margins they earn.Keywords: Partnership Pattern, Qualitative Model, Transactions Cost of Economic
MAINSTREAMING PUBLIC TRUST FOR AGROBIOTECHNOLOGY DEVELOPMENT: PRELIMINARY FINDINGS FROM INDONESIA
Authors: Hidayat Rachmat , Pamungkas Tree Setiawan , Baratha Lukman Wijaya , Mubarok Ahmad Munif
Published: September 2019

This article aims to identify the public trust on the application of Agriculture biotechnology-based products in Indonesia, specifically in the eastern part of East Java Province, which is knowns as Horseshoe region−ex Besuki district. Further, this article will focuses on farmers impediment and their discontent facing the challenges of GM Crops companies for mainstreaming their products in their locality. This article will also expand the discussion on the urgency for local government governance for a sustainable regulatory policy which forbids the rudimentary practice of bad corporate governance Genetically modified (GM) crops in the locality

Keyword: Public Trust, Agrobiotechnology Farmers, Policy
THE EFFECT OF E-PROCUREMENT APPLICATION AND EMPLOYEE COMPETENCY TOWARD EMPLOYEE PERFORMANCE (STUDY AT LPSE AND ULP GOVERNMENT OF SURABAYA CITY)
Authors: Lucca Anggie Parawitha
Published: September 2019

The background of the research is the importance of e-procurement application and employee competency toward employee performance. Basically, there are some factors or variables that can affect employee performance (Y). However, There are two factors or variables that will be discussed in this research such as w-Procurement (X1) application and employee competency (X2). the aim of this research was to explain and analyze the effect of e-procurement application and employee competency toward employee performance simultaneously and partially. The type of research used in this research was explanatory research with qualitative approach. Respondents in this research were employees of LPSE and ULP Surabaya Governmenr. Research Instrument test as followed: Normality test, Linearity Test, Multicollinearity test and Heteroscedacity test. Data analysis technique as followed: descriptive data analysis, Correlation Coefficient Analysis, Multiple Linear Regression Analysis, Simple Linear Regression Analysis, Determination Coefficient, and proof of hypothesis through F (simultaneous) and t (partial) Tests. The statistic result of the result showed that there was positive and significant effect between e-Procurement application and employee competency simultaneously and partially toward employee performance.

Key Words: E-procurement application (X1), Employee Competency (X2), Employee Performance
THE EFFORT OF WEST SUMATRA PROVINCE TO EMBRACE HALAL TOURISM
Authors: Pratama Arinaldo Habib , Sulistiyanto Sulistiyanto , Ali Yusuf
Published: September 2019

In order to embrace economic resilience as form of national resilience, tourism effort is needed so every provinces in Indonesia able to introduce any potential that they have globally. Halal tourism is one way to gaining lucrative prospect from muslim tourist, since muslim travellers are spending USD 220 billion annually. For the start, at 2012, Indonesia’s Ministry of Tourism introduced 12 provinces as halal tourism destinations and adopt some regulations to facilitate the implementation and activation of halal tourism , including West Sumatra. Halal tourism in West Sumatra already got recognition in form of achievements, such as The World Halal Tourism Award 2016 and Anugerah Wisata Halal Nasional 2016 from Indonesia’s Ministry of Tourism. This study will explain how West Sumatra able to develop themselves as one of halal tourism destination in Indonesia. Concepts that will be used in this study are public policy and branding strategy.The research conducted with qualitative research. The result of this research is through public policy and branding in tourism effort, West Sumatra succesfully convince the tourist that the province is friendly toward muslim tourist through various rules and incentive toward shareholder that responsible to promote halal tourism effort. Also, as province that mostly populated by muslim, West Sumatra’s branding effort succesfully show that religion and culture able to go along together.

Keyword: Halal Tourism, West Sumatra, Public Policy, Branding
THE IDENTIFICATION OF LEARNING NEEDS AS THE BEGINNING IN ORGANIZING EMPOWERMENT PROGRAM AT PANDHALUNGAN SOCIETY IN THE PURLIEUS OF JEMBER
Authors: Hasan Fuad , Fajarwati Linda , Alqornia Sylva
Published: September 2019

In optimizing achievement of educational objective, the identification of learning needs become urgent to be conducted, especially for non formal education progam. Ths study is conducted to reveal Pandhalungan societies learning need in the purlieus of Jember. It is used qualitative approach with ethnography as its research design. The ethnography is chosen because the researcher want to describe Jember societies learning need in the purlieus which a part of Pandhalungan ethnic.  This study is done by four step, it was preliminary study, deciding problem category, data collecting, and data interpretation. Data collecting is done by observation, interview, and documentation study. Data Validity is done by triangulation method and resources. This study showed that Pandhalungan societies in the purlieus of Jember have literacy, equality education, life skill, and penyuluhan as their priority learning needs.

Key words: Identification of learning needs, Pandhalungan society, purlieus of jember
What’s in a Name? Unpacking Students’ Roles in Higher Education through Neoliberal and Social Justice Lenses
Authors: Dollinger Mollie , Mercer-Mapstone Lucy
Published: September 2019

There has been an increase in research and practice exploring how students can gain agency to shape higher education experiences. Numerous terms evoking certain metaphors have entered the discussions around engaging students, from students as consumers or producers, to students as creators, partners, or change agents. There is scope within the evolving literature to explore the differentiations between these metaphors and how underlying assumptions ultimately shape our practices and research. We thus unpack the above five metaphors frequently used to redefine students’ roles in higher education. We then engage in a dialogue across differences: highlighting how our own two distinct perspectives on the research area and practice – grounded in neoliberalism and social justice – align, overlap, differ, and provide constraints or affordances for student engagement. We offer a critical and reflective commentary questioning the drivers of students’ changing roles in higher education in the hope of inviting others into generative dialogue toward expanding the evolving field of student engagement.
Data-Driven Predictive Modeling of Neuronal Dynamics using Long Short-Term Memory
Authors: Plaster Benjamin , Kumar Gautam
Published: September 2019

Modeling brain dynamics to better understand and control complex behaviors underlying various cognitive brain functions are of interests to engineers, mathematicians, and physicists from the last several decades. With a motivation of developing computationally efficient models of brain dynamics to use in designing control-theoretic neurostimulation strategies, we have developed a novel data-driven approach in a long short-term memory (LSTM) neural network architecture to predict the temporal dynamics of complex systems over an extended long time-horizon in future. In contrast to recent LSTM-based dynamical modeling approaches that make use of multi-layer perceptrons or linear combination layers as output layers, our architecture uses a single fully connected output layer and reversed-order sequence-to-sequence mapping to improve short time-horizon prediction accuracy and to make multi-timestep predictions of dynamical behaviors. We demonstrate the efficacy of our approach in reconstructing the regular spiking to bursting dynamics exhibited by an experimentally-validated 9-dimensional Hodgkin-Huxley model of hippocampal CA1 pyramidal neurons. Through simulations, we show that our LSTM neural network can predict the multi-time scale temporal dynamics underlying various spiking patterns with reasonable accuracy. Moreover, our results show that the predictions improve with increasing predictive time-horizon in the multi-timestep deep LSTM neural network.
Integrating Environmental Variables by Multivariate Ordination enables the Reliable Estimation of Mineland Rehabilitation Status
Authors: Gastauer Markus , Ramos Silvio , Caldeira Cecílio , Trevelin Leonardo , Jaffé Rodolfo , Oliveira Guilherme , Vera Mabel , Pires Eder , Santiago Flavia , Carneiro Marco , Coelho Felipe , Silva Rosilene , Souza-Filho Pedro Walfir M. , Siqueira José
Published: September 2019

Despite the wide variety of variables commonly applied to measure different aspects of rehabilitation, the assessment and subsequent definition of indicators of environmental rehabilitation status are not simple tasks. The main challenges are comparing rehabilitated sites with target ecosystems as well as integrating individual environmental and eventually collinear variables into a single tractable measure of the state of a system before effective indicators that track rehabilitation may be modeled. For that, a consensus is lacking regarding which and how many variables need to be surveyed. Our approach considered ecological processes, vegetation structure, and community diversity from nonrehabilitated, rehabilitating and reference sites. We applied this approach to a curated set of 32 environmental variables retrieved from nonrevegetated, rehabilitating and reference sites associated with iron ore mines from the Urucum Massif, Mato Grosso do Sul, Brazil. By integrating variables from a single attribute or the entire set of variables into a single estimation of rehabilitation status, the proposed multivariate approach is straightforward and able to adequately address collinearity among variables. The proposed approach allows for the identification of biases towards single variables, surveys or analyses, which is necessary to rank environmental variables regarding their importance to the assessment. Furthermore, we show that bootstrapping permitted the detection of the minimum number of environmental variables necessary to achieve reliable estimations of the rehabilitation status. Finally, we show that the proposed variable integration enables the definition of environmental indicators for more comprehensive monitoring of mineland rehabilitation. Thus, the proposed multivariate ordination represents a powerful tool to outline the benefits of rehabilitating sites for the maintenance of biodiversity and ecosystem functions and services provided that sufficient environmental variables related to ecological processes, diversity and vegetation structure are gathered from nonrehabilitated, rehabilitating and reference study sites. By identifying deviations from predicted rehabilitation trajectories and providing assessments for environmental agencies, this proposed multivariate ordination increases the effectiveness of (mineland) rehabilitation.
Developing End-to-End Control Policies for Robotic Swarms Using Deep Q-learning
Authors: Wei Yufei , Nie Xiaotong , Hiraga Motoaki , Ohkura Kazuhiro , Car Zlatan ,   Graduate School of Engineering, Hiroshima University 1-4-1 Kagamiyama, Higashi-hiroshima, Hiroshima 739-8527, Japan,   Faculty of Engineering, University of Rijeka 58 Vukovarska, Rijeka 51000, Croatia
Published: September 2019

In this study, the use of a popular deep reinforcement learning algorithm – deep Q-learning – in developing end-to-end control policies for robotic swarms is explored. Robots only have limited local sensory capabilities; however, in a swarm, they can accomplish collective tasks beyond the capability of a single robot. Compared with most automatic design approaches proposed so far, which belong to the field of evolutionary robotics, deep reinforcement learning techniques provide two advantages: (i) they enable researchers to develop control policies in an end-to-end fashion; and (ii) they require fewer computation resources, especially when the control policy to be developed has a large parameter space. The proposed approach is evaluated in a round-trip task, where the robots are required to travel between two destinations as much as possible. Simulation results show that the proposed approach can learn control policies directly from high-dimensional raw camera pixel inputs for robotic swarms.
The Emergence of the Tobacco 21 Movement From Needham, Massachusetts, to Throughout the United States (2003–2019)
Authors: Reynolds Matthew J. , Crane Robert , Winickoff Jonathan P.
Published: September 2019

In February 2003, Needham, Massachusetts, became the first town in the nation to raise the minimum legal sales age for tobacco and nicotine products to 21 years (Tobacco 21). This legislation marked a dramatic departure from existing state and federal laws, which generally set the minimum sales age at 18 years. The Needham law significantly preceded and ultimately heralded the emergence of a nationwide movement to raise such sales age. As of May 2019, 14 states and more than 450 cities and counties have passed legislation raising the minimum legal sales age for tobacco and nicotine products to 21 years, covering more than 30% of the United States’ population. The National Academy of Medicine projects that this policy will lower tobacco use rates, particularly among adolescents, and save a substantial number of lives. This narration of the process that led to Needham’s passing of Tobacco 21 legislation and to the growth and spread of the Tobacco 21 movement highlights the significant role of public health advocacy and policy in the control of tobacco, the leading preventable cause of disease and death in the United States. (Am J Public Health. 2019;109:1540–1547. doi: 10.2105/AJPH. 2019.305209)
Shift Work and Poor Mental Health: A Meta-Analysis of Longitudinal Studies
Authors: Torquati Luciana , Mielke Gregore I. , Brown Wendy J. , Burton Nicola W. , Kolbe-Alexander Tracy L.
Published: September 2019

Background. Shift work is characterized by employees working outside the standard hours of 7:00 am to 6:00 pm. Because shift work includes night work, the normal sleep–wake cycle (circadian rhythm) is disrupted, with potential consequences for shift workers’ physical and mental health.

Objectives. To assess the pooled effects of shift work on mental health and to evaluate whether these differ in men and women.

Search Methods. We searched PubMed, Scopus, and Web of Science databases for peer-reviewed or government reports published up to August 2018

Selection Criteria. To be included, studies had to be longitudinal or case–control studies of shift work exposure associated with adverse mental health outcomes. For subanalyses, we grouped these outcomes as anxiety symptoms, depressive symptoms, or general poor mental health symptoms.

Data Collection and Analysis. We followed the Meta-Analysis of Observational Studies in Epidemiology Group guidelines. We extracted adjusted risk estimates for each study to calculate pooled effect sizes (ESs) using random effect models and metaregression analysis to explore sources of heterogeneity.

Main Results. We included 7 longitudinal studies, with 28 431 unique participants. Shift work was associated with increased overall risk of adverse mental health outcomes combined (ES = 1.28; 95% confidence interval [CI] = 1.02, 1.62; I2 = 70.6%) and specifically for depressive symptoms (ES = 1.33; 95% CI = 1.02, 1.74; I2 = 31.5%). Gender differences explained more than 90% of heterogeneity, with female shift workers more likely to experience depressive symptoms than female non–shift workers (odds ratio = 1.73; 95% CI = 1.39, 2.14).

Authors’ Conclusions. To our knowledge, this is the first meta-analysis to investigate the pooled effects of shift work on the risk of poor mental health, including subanalyses by type of poor mental health and gender. Shift workers, particularly women, are at increased risk for poor mental health, particularly depressive symptoms.

Public Health Implications. Depression accounts for 4.3% of the global burden of disease and incidence, with mental disorders worldwide predicted to cost US $16.3 million by 2030. With 1 in 5 people in the United States and Europe doing shift work, and the increased risk of poor mental health among shift workers, shift work industries are a priority context for reducing this burden. Workplace health promotion programs and policies are needed to minimize shift workers’ risk of poor mental health.
Características generales de la educación médica en México. Una mirada desde las escuelas de medicina
Authors: Fajardo-Dolci Germán E , Santacruz-Varela Javier , Lara-Padilla Eleazar , García-Luna Martínez Eduardo , Zermeño-Guerra Alejandro , Gómez Julio César
Published: September 2019

Objetivo. Conocer las características de la educación médica e identificar sus fortalezas y debilidades. Material y métodos. Se realizó un estudio transversal y cuantitativo para conocer las características de la educación médica en 29 escuelas de medicina en México, entre abril y septiembre de 2017. Se utilizó un cuestionario con escala tipo Likert para explorar el contexto, la regulación, la estructura, el proceso, los resultados y el impacto de la educación médica. Se realizó un análisis bivariado con ji cuadrada y una significancia esta­dística de p igual o menor a 0.05 Resultados. El contexto político obtuvo 64%, el contexto económico 10%, los meca­nismos de regulación 31%, la estructura educativa 61% y el impacto social 93%. Conclusiones. Se requiere fortalecer las políticas públicas, la regulación y la inversión pública, para mejorar la calidad de la educación médica.
Association between rotavirus gastroenteritis and intussusception: suggested evidence from a retrospective study in claims databases in the United States. Corresponding author: Corinne Willame, MPH, GSK, 20 Avenue Fleming, Wavre, Belgium
Authors: Willame Corinne , Cheuvart Brigitte , Aris Emmanuel , Vetter Volker , Cohet Catherine
Published: September 2019

Background: The etiology of intussusception (IS), a serious medical condition of acute gastrointestinal obstruction, remains unclear. Limited evidence suggests a role for viral infections, including rotavirus infection. This study aimed to explore the risk of IS after rotavirus gastroenteritis (RV GE) in the first year of life, where the incidence of IS is highest. Methods: In this retrospective, self-controlled case series (SCCS), we assessed the risk of IS after RV GE in infants <1 year of age, using data extracted from administrative claims databases in the United States. Incidence rate ratios (IRR) of IS were calculated for the 7- and 21-day risk periods after RV GE (main analysis) or after fracture (sensitivity analysis using a control event) in subjects presenting with claims for these conditions. Post-hoc analyses were also performed. Results: Out of the 290,912,068 subjects screened, 42 subjects presented claims for RV GE and IS (RV GE group) and 66 presented claims for fracture and IS (fracture group). The IRR of IS after RV GE was 79.6 (95% confidence interval, CI: 38.6–164.4) in the 7-day risk period and 25.5 (95% CI: 13.2–49.2) in the 21-day risk period. The sensitivity analysis also showed an association between IS and fracture for the two risk periods: IRR was 6.1 (95% CI: 3.0–12.7) and 2.8 (95% CI: 1.5–5.4) in the 7- and 21-day risk periods, respectively, which suggested potential confounding such as by history of rotavirus vaccination, or a visit effect. Post-hoc analyses investigating these points did not confirm an association between fracture and IS, but still suggested a possible association between RV GE and IS. Conclusions: A temporal association between RV GE and IS was detected using the SCCS design in United States claims databases. However, due to some limitations identified through additional analyses, further studies are needed to confirm this association.
Need for False Spring Research in the Northern Great Plains, USA
Authors: Kral‐O'Brien Katherine C. , O'Brien Peter L. , Harmon Jason P.
Published: September 2019

Core Ideas

Late spring frosts (false springs) may increase in northern latitudes of the USA.

Researchers need to determine how false springs will affect plants and wildlife.

Special attention is required in vulnerable areas such as the northern Great Plains.

Global climate change is typically characterized by warming average temperatures and more frequent extreme weather events. An understudied component of climate change is the occurrence of false springs, where warm temperatures in early spring prematurely release plants from dormancy, only to be harmed by a late spring frost event. Only limited research has investigated the nature, extent, and impacts of false springs, despite their potential for extreme environmental and economic consequences. More resources should be devoted to false spring research because they are predicted to increase in several regions, especially the northern Great Plains. We review the existing literature on false springs and identify knowledge gaps in both cropland and natural systems. Further, we propose avenues of research, focusing on ecosystems of the northern Great Plains. This research will be crucial in creating strategies that allow land managers to adapt to changing conditions caused by more frequent false springs.
Polyphenolic Profile of Seed Components of White and Purple Flower Pea Lines
Authors: Jha Ambuj B. , Purves Randy W. , Elessawy Fatma M. , Zhang Haixia , Vandenberg Albert , Warkentin Thomas D.
Published: September 2019

Polyphenols play roles in plant defense mechanisms and are natural sources of antioxidants in food. A pea (Pisum sativum L.) recombinant inbred line (RIL) population (PR‐20) was developed from CDC Amarillo (white flower) and CDC Dakota (purple flower). Approximately half of the lines had white flowers and half had purple flowers, and these had two seed coat types (speckled and dun). The objective of this study was to use liquid chromatography coupled with mass spectrometry to compare polyphenolic profiles of seed components of four randomly selected PR‐20 lines from each of these three distinct groups to identify polyphenols that can be targeted in pea breeding. We quantified 30, 29, and 27 polyphenols in whole seeds, seed coats, and cotyledons, respectively. Except for gallic acid in whole seeds, no differences were observed between speckled and dun seed coats. Compared with white flower lines, 24, 23, and 12 compounds were at greater concentration in seed coats (3–6100 times), whole seeds (2–820 times) and cotyledons (2–110 times) of purple flower lines. Cotyledons of purple flower lines contained eight times more 3,4‐dihydroxybenzoic acid and 110 times more epigallocatechin than white flower lines. Ferulic acid, dihydrokaempferol, and kaempferol 3‐O‐glucoside were two to three times greater in cotyledons of white flower vs. purple flower lines. This study provides a basis for exploration of pea germplasm to identify accessions with high polyphenol content for breeding pea cultivars with improved health benefits in human diets.
Aerated Irrigation Promotes Soil Respiration and Microorganism Abundance around Tomato Rhizosphere
Authors: Zhu Yan , Cai Huanjie , Song Libing , Chen Hui
Published: September 2019

Core Ideas

Aerated irrigation improved soil aeration, increasing oxygen concentration and air‐filled porosity.

Aerated irrigation enhanced soil, microbial, and root respiration and microbe abundance.

Soil oxygen, air‐filled porosity correlated with respiration, microbe abundance.

Aerated irrigation has economic benefits, promoting fruit yield and IWUE.

Aerated irrigation (AI), by which aerated water is supplied to soil through subsurface drip irrigation (SDI), has shown high yield potential and application prospects. This study evaluated the impact of AI on soil aeration, respiration components, and microorganism abundance to determine the relationships between these parameters. Four treatments (W1AI, W2AI, W1CK, and W2CK) combining AI and nonaerated SDI (CK) and two irrigation levels (W1 and W2, with crop‐pan coefficients of 0.6 and 1.0) were conducted in a greenhouse during two tomato (Lycopersicon esculentum Mill.) growing seasons in April to July in 2015 and 2016. The results showed that AI improved soil aeration conditions, with soil oxygen concentration and air‐filled porosity significantly increasing by 5.86 and 5.16%, respectively, compared with CK. The W1AI treatment increased soil, microbial, and root respiration as well as bacteria, actinomycetes, and fungi abundance by 18.8, 10.0, 23.4, 30.1, 29.4, and 30.1%, respectively, compared with W1CK, and W2AI significantly increased these by 24.2, 15.3, 28.7, 39.2, 39.3, and 37.1%, respectively, compared with W2CK. Moreover, the abundance of bacteria, actinomycetes, and fungi with W2AI significantly increased by 26.9, 27.1, and 24.8%, respectively, compared with W1AI. Soil oxygen concentration (under controlled soil temperature) and air‐filled porosity positively correlated with soil respiration and microorganism abundance. Mean fruit yield with AI was 22.4% higher than CK. Aerated irrigation therefore stimulated soil respiration and microbial proliferation by improving soil aeration conditions. Enhanced soil aeration, respiration, and microorganism abundance under AI provide economic benefit by improving fruit yield.
Enhancing Speaking Skills in the Material of Remedial Learning Through Community Language Learning in SMP Multazam Semarang
Authors: Muttaqin Muhamad Zayyinul
Published: September 2019

This paper highlighted how extremely English language learning that sometimes seemed threatening pupils in the classroom where they were unable to express much attention and confidence. They quantitatively got the worst score for this subject due to several aspects that must be comprehended by students: pronunciation, grammatical structure, vocabulary, and intonation. As long as, students participated in the teaching-learning process, they had standardly done all of the assessment. Therefore, teachers here as the facilitator or counselor should redesign the classroom’s atmosphere and its method; instead, it would invite students to show their best performance. Community Language Learning (CLL) displayed how effectively and efficiently English should be taught. Thus, this research is qualitatively reported to observe how CLL was able to increase the students’ speaking skill in the Material of Remedial Learning for students’ eight grade in SMP Multazam with the total number of 26 students. An observation sheet and the score ranking sheet were as data collection to consider the names. A fluency, a pronunciation, an expression, a vocabulary, and content were the instrument to analysis their performance. This study was Classroom Action Research which revealed that the students are comfortable in joining learning’s experience, and its effects to their competence in speaking skill with the amount of enhancement through 2 cycles; post-test 1 and post-test 2.  CLL was considered to be an effective method since it contributed to the prominent effect of speaking skill.
Attitude of Foreign Language Learners on Nonverbal Communication and Privacy in Communicative Classes
Authors: Nemati Azedah
Published: September 2019

Communication has verbal and nonverbal aspects.It has been estimated that 82% of class communication is nonverbal. While the role of nonverbal behavior in English classes is much it is hitherto an unexplored area. One subpart of nonverbal communication is proxemics or space. Combing nonverbal communication and the right to privacy, this article is aimed at exploring the attitude of foreign language students regarding nonverbal communication and privacy right in English classes. A nonverbal questionnaire along with privacy proposed by the researcher was answered by 107 general English participants. Based on their opinion the major findings were that students like, smiling, tidy and on time teachers who explain and illustrate in English classes. However, they do not like to answer questions regarding their personal life such as personal description, identification, health or background. As a result, their privacy right should be observed in communicative English classes.
The Role of Self-Efficacy in Students’ Writing Ability (A Case Study at Second Grade Students of a Senior High School in Indramayu)
Authors: Yulianawati Ida
Published: September 2019

This case study aimed at investigating the role of self-efficacy in students’ recount text especially in the area of writing as one of the most difficult skills in learning English. Writing difficulties faced by the students are not only based on their cognitive skill but also their own efficacy beliefs. Three problems can be found related to self-efficacy beliefs in English writing. They are related with confidence to write anxiety, and the third problem is about the students’ interest. The participants of this study are three students from a Senior High School in Indramayu. The data were obtained from three data collection: questionnaire, writing test, and also the interview. The result of this study shows that the participants of this study perceived mastery experience accounted for the greatest proportion in their writing ability. It can be seen from how students rate their confidence and given overall feelings about the way to write successfully. Social persuasions and physiological states also were influential while working on writing. Meanwhile, the common experience did not predict too much in students' writing ability. Ultimately, the results of this research concluded that self-efficacy has an important role in students’ ability in writing.
Improving the water transpiration in a solar steam generation device
Authors: Meng Yuan , Li Haibo
Published: September 2019

Solar steam generation (SSG) has been proposed as one of the most advanced techniques to trigger solar energy desalination of sea water. Although many efforts have been dedicated to develop SSG devices, the efficiency remains relatively low. Previous work was mainly focused on thermal insulation film and light absorption. Attention has seldom been concentrated on device structure. Inspired by the manner of water transportation within flowers, we designed an artificial SSG unit which can effectively speed up the water transpiration from the bulk to the surface. Another advantage of such a device is that steam generation is separated from the bulk salty solution and thereby the solar thermal evaporation can be improved greatly. As demonstrated via the desalination experiment, the mass change and evaporation rate under 1 solar irradiation can reach as high as 2.51 kg/m2 and 1.26 kg/m2·h−1, respectively. Meanwhile, the evaporation efficiency is 74%. These values are much higher than those of traditional SSG devices and bulk water.
Sosyal Medya Platformu Seçimini Etkileyen Kriter Ağırlıklarının Bulanık DEMATEL Yöntemiyle Belirlenmesi
Authors: Oralhan Burcu
Published: September 2019

Hızlı
etkileşim günümüzde sosyal medyanın sahip olduğu en önemli özelliklerinden
biridir. İşletmelerin reklam faaliyetlerinde sosyal medya, diğer pazarlama
kanallarına göre daha fazla kişiye ulaşabilme imkanı sağlamaktadır. Ancak dünya
genelinde sosyal medya platformlarının sayısı gün geçtikçe artmakta ve bu
platformlardaki tüketici eğilimi değişiklik göstermektedir. İşletmeler
tarafından yatırım yapılacak olan reklam faaliyetine yönelik sosyal medya
platformunun belirlenmesi bir çok kriterli karar verme problemidir. Sosyal
medya platformu seçim problemleri çok sayıda ve çoğu zaman birbiriyle çelişen
kriterler içeren karmaşık problemlerdir. Bu araştırmada Türkiye’de
telekomünikasyon sektöründe öncü bir işletmenin sosyal medya platformlarının
seçiminde önem arz eden kriterlerin ve etki düzeylerinin belirlenmesi ve
ağırlıklarının hesaplanması amaçlanmaktadır. Ağırlıkların hesaplanmasında
Bulanık DEMATEL yönteminden, durulaştırma aşamasında ise CFCS yönteminden
faydalanılmıştır. Araştırma kapsamında görünüm ve algı, içerik, maliyet, üye
profili, izlenim oranı ve teknik destek olmak üzere 6 kriter belirlenmiştir.
Analiz sonuçlarına göre izlenme oranı (0,185), 
görünüm ve algı (0,181) ve üye profili (0,170) kriterleri sosyal medya
platformu seçiminde en fazla ağırlığa sahip ilk üç kriter olarak karşımıza
çıkmıştır. E+F değeri kriterlerin göreli önemini ifade
etmektedir.  E-F  değerleri
pozitif olan izlenme oranı, görünüm ve algı ve üye profili kriterleri diğer
kriterleri etkileyen grupta yer almaktadır. Dolayısıyla bu kriterlerin, diğer
kriterler üzerinde en çok etkiye sahip olduklarını söylenebilir. E-F değerleri
negatif olan maliyet, içerik ve teknik destek kriterleri ise etkilenen grupta
yer almaktadır. Etkilenen kriterler incelendiğinde ise E-F değeri en küçük olan maliyet kriterinin sosyal
medya platform seçiminde diğer kriterlerden en çok etkilenen kriter olduğu
görülmektedir. Bu çalışma genel olarak dijital pazarlama kanallarının seçimine,
kriter ağırlıklarının ve kriterlerin etki düzeylerinin belirlenmesine yönelik
yapılacak araştırmalara farklı bir bakış açısı kazandıracaktır.
Same Target, Different Therapeutic Outcomes: The Case of CAY10471 and Fevipiprant on CRTh2 Receptor in Treatment of Allergic Rhinitis and Asthma
Authors: Issahaku Abdul R. , Agoni Clement , Soremekun Opeyemi S. , Kubi Patrick A. , Kumi Ransford O. , Olotu Fisayo A. , Soliman Mahmoud E.S.
Published: September 2019

Objective:

Prostaglandin 2 (PGD2) mediated signalling of Chemoattractant Receptorhomologous molecule expressed on Th2 cells (CRTh2) receptor has been implicated in the recruitment of inflammatory cells. This explains the design of highly selective compounds with innate abilities to antagonize PGD2-CRTh2 interactions and prevent pro-inflammatory allergies such as rhinitis and uncontrolled asthma. The development of PGD2-competitive CRTh2 binders; CAY10471 and Fevipiprant represent remarkable therapeutic progress even though they elicit disparate pharmacological propensities despite utilizing the same binding pocket.

Methods & Results:

In this study, we seek to pinpoint the underlying phenomenon associated with differential CRTh2 therapeutic inhibition by CAY10471 and Fevipiprant using membraneembedded molecular dynamics simulation. Findings revealed that the common carboxylate group of both compounds elicited strong attractive charges with active site Arg170 and Lys210. Interestingly, a distinctive feature was the steady occurrence of high-affinity salt-bridges and an Arg170-mediated pi-cation interaction with the tetrahydrocarbozole ring of CAY10471. Further investigations into the active site motions of both ligands revealed that CAY10471 was relatively more stable. Comparative binding analyses also revealed that CAY10471 exhibited higher ΔG, indicating the cruciality of the ring stabilization role mediated by Arg170. Moreover, conformational analyses revealed that the inhibitory activity of CAY10471 was more prominent on CRTh2 compared to Fevipiprant.

Conclusion:

These findings could further advance the strategic design of novel CRTh2 binders in the treatment of diseases related to pro-inflammatory allergies.
Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages
Authors: Abdella Amna M. , Abdelmoniem Amr M. , Ibrahim Nada S. , El-Hallouty Salwa M. , Abdelhamid Ismail A. , Elwahy Ahmed H.M.
Published: September 2019

Objective:

Novel bis(1,4-dihydropyridine-3,5-dicarbonitrile) derivatives linked to aliphatic or aromatic cores via amide or ester-amide linkages were prepared and their structures were confirmed by several spectral tools.

Methods:

The synthesis of novel N,N'-(alkanediyl)bis(2-(2-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin- 4-yl)phenoxy)acetamide) by acid-catalyzed condensation of the bis-aldehydes with four equivalents of 3-aminocrotononitrile was reported.

Results:

The structures of the synthesized compounds were confirmed by different spectral tools. The molecular docking stimulation studies indicated that the prepared compounds bind to the active site of cellular inhibitor apoptotic protein (cIAP1-BIR3). MTT assay for the novel bis(1,4-dihydropyridines) was performed on two different human cell lines (A549 and HCT116).

Conclusion:

Compound 5a showed higher cytotoxic activity against A549. Compound 5d showed moderate activity against HCT116. The rest of compounds indicated lower or no activity against both cell lines.
Quantitative Structure-Activity Relationship Study for HIV-1 LEDGF/p75 Inhibitors
Authors: Li Yang , Tian Yujia , Xi Yao , Qin Zijian , Yan Aixia
Published: September 2019

Background:

HIV-1 Integrase (IN) is an important target for the development of the
new anti-AIDS drugs. HIV-1 LEDGF/p75 inhibitors, which block the integrase and LEDGF/p75
interaction, have been validated for reduction in HIV-1 viral replicative capacity.

Methods:

In this work, computational Quantitative Structure-Activity Relationship (QSAR) models
were developed for predicting the bioactivity of HIV-1 integrase LEDGF/p75 inhibitors. We collected
190 inhibitors and their bioactivities in this study and divided the inhibitors into nine scaffolds
by the method of T-distributed Stochastic Neighbor Embedding (TSNE). These 190 inhibitors
were split into a training set and a test set according to the result of a Kohonen’s self-organizing
map (SOM) or randomly. Multiple Linear Regression (MLR) models, support vector machine
(SVM) models and two consensus models were built based on the training sets by 20 selected
CORINA Symphony descriptors.

Results:

All the models showed a good prediction of pIC50. The correlation coefficients of all the
models were more than 0.7 on the test set. For the training set of consensus Model C1, which performed
better than other models, the correlation coefficient(r) achieved 0.909 on the training set,
and 0.804 on the test set.

Conclusion:

The selected molecular descriptors show that hydrogen bond acceptor, atom charges
and electronegativities (especially π atom) were important in predicting the activity of HIV-1 integrase
LEDGF/p75-IN inhibitors.
Association between hTERT Polymorphisms and Female Papillary Thyroid Carcinoma
Authors: Liu Ying , Li Zhi , Tang Xinyue , Li Min , Shi Feng
Published: September 2019

Background:

A previous genome-wide association study showed that hTERT rs10069690
and rs2736100 polymorphisms were associated with thyroid cancer risk.

Objective:

This study further investigated the association between increased risk and clinicopathologic
characteristics for Papillary Thyroid Carcinoma (PTC) and hTERT polymorphisms rs10069690 or
rs2736100 in a Chinese female population.

Methods:

The hTERT genotypes of 276 PTC patients and 345 healthy subjects were determined with
regard to SNPs rs10069690 and rs2736100. The association between these SNPs and the risk of PTC
and clinicopathologic characteristics was investigated by logistic regression.

Results:

We found a significant difference between PTC and rs10069690 (Odds Ratio (OR) = 1.515; P
= 0.005), but not between PTC and rs2736100. When the analysis was limited to females, rs10069690
and rs2736100 were both associated with increased risk for PTC in female individuals (OR = 1.647, P
= 0.007; OR = 1.339, P = 0.041, respectively). Further haplotype analysis revealed a stimulative effect
of haplotypes TC and CA of TERT rs10069690-rs2736100, which increased risk for PTC in female
individuals (OR = 1.579, P = 0.014; OR = 0.726, P = 0.025, respectively). Furthermore, the heterozygote
A/C of rs2736100 showed significant difference for age (OR = 0.514, P = 0.047).

Conclusion:

Our finding suggests that hTERT polymorphisms rs10069690 and rs2736100 are associated
with increased risk for PTC in Chinese female population and rs2736100 may be related to age.
Consistent with US20170360914 and US20170232075, they are expected to be a potential molecular
target for anti-cancer therapy.
Transcriptional Regulation Analysis of Alzheimer's Disease Based on FastNCA Algorithm
Authors: Sun Qianni , Kong Wei , Mou Xiaoyang , Wang Shuaiqun
Published: September 2019

Background:

Understanding the relationship between genetic variation and gene expression
is a central issue in genetics. Although many studies have identified genetic variations associated
with gene expression, it is unclear how they perturb the underlying regulatory network of
gene expression.

Objective:

To explore how genetic variations perturb potential transcriptional regulation networks
of Alzheimer’s disease (AD) to paint a more complete picture of the complex landscape of transcription
regulation.

Methods:

Fast network component analysis (FastNCA), which can capture the genetic variations
in the form of single nucleotide polymorphisms (SNPs), is applied to analyse the expression activities
of TFs and their regulatory strengths on TGs using microarray and RNA-seq data of AD.
Then, multi-data fusion analysis was used to analyze the different TGs regulated by the same TFs
in the different data by constructing the transcriptional regulatory networks of differentially expressed
genes.

Results:

the common TF regulating TGs are not necessarily identical in different data, they may be
involved in the same pathways that are closely related to the pathogenesis of AD, such as immune
response, signal transduction and cytokine-cytokine receptor interaction pathways. Even if they are
involved in different pathways, these pathways are also confirmed to have a potential link with
AD.

Conclusion:

The study shows that the pathways of different TGs regulated by the same TFs in different
data are all closely related to AD. Multi-data fusion analysis can form a certain complement
to some extent and get more comprehensive results in the process of exploring the pathogenesis
of AD.
Skin Allergy to Azole Antifungal Agents for Systemic Use: A Review of the Literature
Authors: Calogiuri Gianfranco , Garvey Lene H. , Nettis Eustachio , Romita Paolo , Di Leo Elisabetta , Caruso Riccardo , Butani Lavjay , Foti Caterina
Published: September 2019

Background:

Antifungal azoles are the first-line agents used to treat topical and, above all,
systemic mycosis. The latter could be life-threating infections in immunocompromised patients. Chemotherapeutic
antibiotics, including antifungal azoles, may induce hypersensitivity reactions; however,
such immunologic adverse reactions have not been defined and carefully investigated.

Objective:

The study aims to provide an update on the evaluation and diagnosis of skin allergy to azole
antifungal agents.

Methods:

This is a systematic review performed on PubMed and Google Schoolbarusing using the key
terms “allergy, hypersensitivity, anaphylaxis, immediate-type reaction, delayed-type reaction, ketoconazole,
fluconazole, posaconazole, voriconazole, itraconazole, triazoles, imidazoles, antifungals,
antimycotics”. The search strategy included meta-analyses, randomized controlled trials, clinical trials,
observational studies, reviews and case reports.

Results:

One hundred twenty-four articles matched our search terms. The most common adverse events
reported were T-cell mediated delayed-type hypersensitivity reactions, fixed drug eruptions, exanthematous
dermatitis, Steven-Johnson syndrome, toxic epidermal necrolysis and acute generalized exhanthematous
pustulosis. Rarely a drug rash with eosinophilia systemic symptoms, has been described.
Also, immediate-type reactions such as urticaria-angioedema or anaphylaxis have been reported following
the administration of antifungal imidazoles, although not so frequently.

Conclusion:

Despite their widespread use, triazoles seem to induce rare cutaneous hypersensitivity
reactions, but the pathomechanisms, risk factors, diagnostic and management strategies, including skin
tests and challenge tests, are little known and poorly investigated.
Lanthanide Doped Complexes and Organometallic Clusters: Design Strategies and their Applications in Biology and Photonics
Authors: Kumar Gangadharan A.
Published: September 2019

In this review, we discuss the rational design of a new class of lanthanide-doped organometallic nanostructured materials called `molecular minerals`. Molecular minerals are nanostructured materials with a ceramic core made from chalcogenide groups and other heavy metals. Part of the central core atoms is replaced by suitable lanthanide atoms to impart fluorescent spectral properties. The ceramic core is surrounded by various types of organic networks thus making the structure partly ceramic and organic. The central core has superior optical properties and the surrounding organic ligand makes it easy to dissolve several kinds of organic solvents and fluoropolymers to make several kinds of active and passive photonic devices. This chapter starts with elaborate design strategies of lanthanidebased near-infrared emitting materials followed by the experimental results of selected near-infrared emitting lanthanide clusters. Finally, their potential applications in telecommunication, light-emitting diodes and medical imaging are discussed.