bluuebunny/crossref_metadata_2025 huggingface dataset:
Highly Enantio‐ and Regioselective Quinone Diels—Alder Reactions Catalyzed by a Tridentate [(Schiff Base)CrIII] Complex.
Authors: Jarvo Elizabeth R. , Lawrence Brian M. , Jacobsen Eric N.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Catalytic Asymmetric Cyanosilylation of Ketones by a Chiral Amino Acid Salt.
Authors: Liu Xiaohua , Qin Bo , Zhou Xin , He Bin , Feng Xiaoming
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Selective Synthesis of Isocyanides from Secondary Alcohols by a New Type of Oxidation—Reduction Condensation.
Authors: Masutani Kouta , Minowa Tomofumi , Mukaiyama Teruaki
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Zn/CuI‐Mediated Coupling of Alkyl Halides with Vinyl Sulfones, Vinyl Sulfonates, and Vinyl Sulfonamides.
Authors: Zhao Matthew M. , Qu Chuanxing , Lynch Joseph E.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Glycolate Aldol Reactions Using Cinchonium Phase‐Transfer Catalysts.
Authors: Andrus Merritt B. , Liu Jing , Ye Zhifeng , Cannon John F.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Broensted Acid Mediated Double Friedel—Crafts Reaction of Methylenecyclopropanes with Arenes.
Authors: Wang Bao‐Yu , Jiang Ri‐Shan , Li Jia , Shi Min
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Regioselective and Divergent Opening of Vinyl Epoxides with Alkyne Nucleophiles.
Authors: Restorp Per , Somfai Peter
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Addition Reactions to Chiral Aziridine‐2‐carboxaldimine Toward Various Enantiopure Nitrogen‐Containing Heterocycles.
Authors: Noh Heui‐Yoon , Kim Sang‐Woo , Paek Seong In , Ha Hyun‐Joon , Yun Hoseop , Lee Won Koo
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed One‐Pot Synthesis of Highly Substituted Furans by a Three‐Component Annulation Reaction.
Authors: Duan Xin‐hua , Liu Xue‐yuan , Guo Li‐na , Liao Meng‐chun , Liu Wei‐Min , Liang Yong‐min
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Facile Dearomatizing Radical Arylation of Furan and Thiophene.
Authors: Crich David , Patel Mitesh
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Benzo[b]furans via CuI‐Catalyzed Ring Closure.
Authors: Chen Cheng‐yi , Dormer Peter G.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
The N‐Cyclopropylimine‐1‐Pyrroline Photorearrangement as a Synthetic Tool: Scope and Limitations.
Authors: Soldevilla Alberto , Sampedro Diego , Campos Pedro J. , Rodriguez Miguel A.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Versatile Direct Synthesis of Oligosubstituted Pyrroles by Cycloaddition of α‐Metalated Isocyanides to Acetylenes.
Authors: Larionov Oleg V. , de Meijere Armin
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Spiro[4.5]trienones by Intramolecular ipso‐Halocyclization of 4‐(p‐Methoxyaryl)‐1‐alkynes.
Authors: Zhang Xiaoxia , Larock Richard C.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Stereoselective Synthesis of 3‐Alkylideneoxindoles via Palladium‐Catalyzed Domino Reactions.
Authors: Yanada Reiko , Obika Shingo , Inokuma Tsubasa , Yanada Kazuo , Yamashita Masayuki , Ohta Shunsaku , Takemoto Yoshiji
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Michael Addition of Indoles to α,β‐Unsaturated Ketones in an Ionic Liquid.
Authors: Li Wei‐Jun , Lin Xu‐Feng , Wang Jun , Li Guo‐Liang , Wang Yan‐Guang
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Novel Ionic Liquids Based on the Benzimidazolium Cation
Authors: Huang Wei‐Guo , Zhang Su‐Mei , Dai Li‐Yi , Shan Yong‐Kui
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Regio‐ and Stereospecific Synthesis of Novel 3‐Enynyl‐Substituted Thioflavones/Flavones Using a Copper‐Free Palladium‐Catalyzed Reaction.
Authors: Pal Manojit , Dakarapu Rambabu , Parasuraman Karuppasamy , Subramanian Venkataraman , Yeleswarapu Koteswar Rao
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Ruthenium‐Catalyzed Arylation of 2‐Alkenylpyridines with Aryl Bromides: Alternative (E,Z)‐Selectivity to Mizoroki—Heck Reaction.
Authors: Oi Shuichi , Sakai Kaori , Inoue Yoshio
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Quinolines via Pd/C‐Catalyzed Cyclization of 2‐Aminobenzyl Alcohol with Ketones.
Authors: Cho Chan Sik , Ren Wen Xiu , Shim Sang Chul
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
An Enantioselective Entry to cis‐Perhydroisoquinolines.
Authors: Amat Mercedes , Perez Maria , Minaglia Annamaria T. , Casamitjana Nuria , Bosch Joan
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Antiinflammatory and Analgesic Activity of 2H‐3,3‐Dimethyl‐3,4‐dihydroisoquinolin‐1‐ones.
Authors: Vikharev Yu. B. , Shklyaev Yu. V. , Anikina L. V. , Kolla V. E. , Tolstikov A. G.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Intramolecular [4 + 2] Cycloadditions of Benzynes with Conjugated Enynes, Arenynes, and Dienes.
Authors: Hayes Martin E. , Shinokubo Hiroshi , Danheiser Rick L.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and 5‐HT1A, 5‐HT2A Receptor Activity of New β‐Tetralonohydantoins.
Authors: Byrtus Hanna , Pawlowski Maciej , Czopek Anna , Bojarski Andrzej J. , Duszynska Beata , Nowak Gabriel , Klodzinska Aleksandra , Tatarczynska Ewa , Wesolowska Anna , Chojnacka‐Wojcik Ewa
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Ruthenium‐Catalyzed Formation of Aryl(diphenyl)phosphine Oxides by Reactions of Propargylic Alcohols with Diphenylphosphine Oxide.
Authors: Onodera Gen , Matsumoto Hideyuki , Milton Marilyn Daisy , Nishibayashi Yoshiaki , Uemura Sakae
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
A Simple Copper Salt Catalyzed Synthesis of Unsymmetrical Diaryl Selenides and Tellurides from Arylboronic Acids with Diphenyl Diselenide and Ditelluride.
Authors: Wang Lei , Wang Min , Huang Fuping
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Stereoselective Mannich‐Type Reaction of Chlorotitanium α‐Phenylseleno Esters Enolates with Aromatic Aldimines.
Authors: Silveira Claudio C. , Vieira Adriano S. , Braga Antonio L. , Russowsky Dennis
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Facile Synthesis of β‐Organotellurobutenolides via Electrophilic Tellurolactonization of α‐Allenoic Acids.
Authors: Xu Qing , Huang Xian , Yuan Jingqi
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Chemoselective Reduction of β‐Butyltellanyl α,β‐Unsaturated Carbonyl Compounds to Allylic Alcohols.
Authors: Dos Santos Alcindo A. , Castelani Priscila , Bassora Bruno K. , Fogo Jose C. Jr. , Costa Carlos E. , Comasseto Joao V.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Cordiaquinone J and K via B‐Alkyl Suzuki—Miyaura Coupling as a Key Step and Determination of the Absolute Configuration of Natural Products.
Authors: Yajima Arata , Saitou Fumihiro , Sekimoto Mayu , Maetoko Shoichiro , Nukada Tomoo , Yabuta Goro
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Three Polyoxygenated Steroids from the South China Sea Gorgonian Coral Subergorgia reticulata
Authors: Yang Jin , Qi Shu‐Hua , Zhang Si , Wu Jun , Xiao Zhi‐Hui
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Facile Synthesis of Chiral α‐Difluoromethyl Amines from N‐(tert‐Butylsulfinyl)aldimines.
Authors: Li Ya , Hu Jinbo
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Isoquinolone and Protoberberine Alkaloids from Stephania rotunda
Authors: Thuy T. T. , Porzel A. , Franke K. , Wessjohann L. , Sung T. V.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Three New Compounds from the Aerial Parts of Caragana sinica
Authors: Wang Shuguang , Ma Dayou , Hu Changqi
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Short, Enantioselective Total Synthesis of Aflatoxin B2 Using an Asymmetric [3 + 2]‐Cycloaddition Step.
Authors: Zhou Gang , Corey E. J.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Optical Properties of CdS Nanoribbons.
Authors: Kar Soumitra , Satpati B. , Satyam P. V. , Chaudhuri S.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis, Biological and Modeling Studies of 1,3‐Di‐n‐propyl‐2,4‐dioxo‐6‐methyl‐8‐(substituted) 1,2,3,4‐Tetrahydro[1,2,4]‐triazolo[3,4‐f]‐purines as Adenosine Receptor Antagonists.
Authors: Pastorin G. , Bolcato C. , Cacciari B. , Kachler S. , Klotz K.‐N. , Montopoli C. , Moro S. , Spalluto G.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Magnetic Nanoparticles Preparation, Structure and Properties
Authors: Gubin S. P. , Koksharov Yu. A. , Khomutov G. B. , Yurkov G. Yu.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Zeolite/Mesoporous Molecular Sieve Composite Materials
Authors: On Do Trong , Kaliaguine Serge
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
The Synthesis and Properties of Magnetic Nanoparticles
Authors: Drofenik M. , Lisjak D. , Makovec D.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Charge‐Transfer Isomers and Mixed‐Valence Properties
Authors: Crutchley Robert J.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Substitution versus Addition: Dicationic Palladium(II)‐ and Platinum(II)‐Olefin Complexes and Their Reactions with Protic Nucleophiles
Authors: Hahn Christine
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Stereochemical Aspects of Metal Xanthate Complexes: Molecular Structures and Supramolecular Self‐Assembly
Authors: Tiekink Edward R. T. , Haiduc Ionel
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Apples to Apples: A Comparison of Lanthanoid β‐Diketonate Complexes in Molecular Solvents and an Ionic Liquid
Authors: Jensen Mark P. , Beitz James V. , Neuefeind Joerg , Skanthakumar S. , Soderholm L.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Catalytic Enantioselective 1,3‐Dipolar Cycloaddition Reaction of Azomethine Ylides and Alkenes: The Direct Strategy to Prepare Enantioenriched Highly Substituted Proline Derivatives
Authors: Najera Carmen , Sansano Jose M.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of New Supramolecular Polymers Based on Glycosylated Amino Acid and Their Applications
Authors: Mohan Srinivasulu Reddy Krishna , Hamachi Itaru
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Pyrroloiminoquinone Alkaloids: Discorhabdins and Makaluvamines
Authors: Harayama Yu , Kita Yasuyuki
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Chemistry of Indole Alkaloids Related to the Corynanthe‐Type from Uncaria, Nauclea and Mitragyna Plants
Authors: Takayama Hiromitsu , Kitajima Mariko , Kogure Noriyuki
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Organophosphorus Chemistry
Authors: Murphy Patrick J.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Hydroxyalkylation of Nitrogen‐Containing Heterocyclic Compounds
Authors: Lubczak Jacek
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Recent Advances in the Synthesis of Thiophene Polycondensed Heterocycles of Biological Activity
Authors: Quintela Jose M. , Peinador Carlos
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
New Aspects of the “tert‐amino Effect” on the Synthesis of Heterocycles
Authors: Quintela Jose M.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Artificial Molecular Double‐Stranded Helices
Authors: Albrecht Markus
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
A General Method for the Asymmetric Synthesis of 3‐Aryl‐1,2,3,4‐tetrahydroisoquinolines
Authors: Anakabe Eneritz , Badia Dolores , Carrillo Luisa , Vicario Jose L.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Design Synthesis and Biological/Biophysical Evaluation of New Oligopyrrole Carboxamides, Biscarbazoles, Oxocarbazoles and Benzo[a]carbazoles: Antitumor and Antioxidative Compounds
Authors: Lemster Thomas , Pindur Ulf
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis, Stability, Molecular Structures and Some Reactions of Spiro[1H‐azulenium‐1,1′‐cycloalkane] Ions
Authors: Oda Mitsunori , Fukuta Aya , Uchiyama Takuya , Kajioka Takanori , Kuroda Shigeyasu
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Cyclopropenethione Derivatives as Reactive Intermediates in Organic Synthesis
Authors: Matsumura Noboru , Okumura Yasuyuki , Yagyu Yoshio , Mizuno Kazuhiko
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
The Radical Chemistry of Xanthates: A Powerful Tool
Authors: Gagosz Fabien
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Critical Evaluation of Stability Constants of Metal Complexes of Complexones for Biomedical and Environmental Applications
Authors: Anderegg Giorgio , Arnaud‐Neu Francoise , Delgado Rita , Felcman Judith , Popov Konstantin
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Phase Behavior and Thermodynamic Properties of Ionic Liquids, Ionic Liquid Mixtures, and Ionic Liquid Solutions
Authors: Rebelo L. P. N. , Najdanovic‐Visak V. , Gomes de Azevedo R. , Esperanca J. M. S. S. , Nunes da Ponte M. , Guedes H. J. R. , Visak Z. P. , de Sousa H. C. , Szydlowski J. , Canongia Lopes J. N. , et al. et al.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Effects of Tannins and Related Polyphenols on Methicillin‐Resistant Staphylococcus aureus.
Authors: Hatano Tsutomu , Kusuda Miwako , Inada Kazutoshi , Ogawa Tomo‐omi , Shiota Sumiko , Tsuchiya Tomofusa , Yoshida Takashi
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
The Rotational Spectrum and Structure of HOOOH.
Authors: Suma Kohsuke , Sumiyoshi Yoshihiro , Endo Yasuki
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Nickel‐Foam‐Supported Reticilar CoO—Li2O Composite Anode Materials for Lithium Ion Batteries.
Authors: Yu Yan , Chen Chun‐Hua , Shui Jiang‐Lan , Xie Song
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Al20Cp8*X10 (X: Cl, Br): Snapshots of the Formation of Metalloid Clusters from Polyhedral AlnXm Molecules?
Authors: Vollet Jean , Burgert Ralf , Schnoeckel Hansgeorg
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
New Silver(I) Oxotellurates(IV/VI).
Authors: Klein Wilhelm , Curda Jan , Peters Eva‐Maria , Jansen Martin
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Enantioselective Rh‐Catalyzed Hydrogenation of Enol Acetates and Enol Carbamates with Monodentate Phosphoramidites.
Authors: Panella Lavinia , Feringa Ben L. , de Vries Johannes G. , Minnaard Adriaan J.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Diels—Alder Reactions of 2‐(2‐Nitroethenyl)‐1H‐pyrroles and Their Oxygen and Sulfur Analogues with Quinones.
Authors: Noland Wayland E. , Pardi Gianluca
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Electrophilic Nitration of Electron‐Rich Acetophenones.
Authors: Malecki Natacha , Carato Pascal , Houssin Raymond , Cotelle Philippe , Henichart Jean‐Pierre
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Beckmann Rearrangement of Ketoximes and Deprotection of Aldoximes in Solvent‐Free Conditions.
Authors: Banerjee Krishna , Mitra Alok Kumar
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
1,5,7‐Triazabicyclo[4.4.0]dec‐5‐ene (TBD) Catalyzed Michael Reactions.
Authors: Ye Weiping , Xu Junye , Tan Chin‐Tong , Tan Choon‐Hong
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Sonogashira Reaction of Aryl Halides with Propiolaldehyde Diethyl Acetal Catalyzed by a Tetraphosphine/Palladium Complex.
Authors: Lemhadri Mhamed , Doucet Henri , Santelli Maurice
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
VCl3‐Catalyzed Efficient Synthesis of β‐Enamine Esters and Ketones from β‐Keto Esters.
Authors: Rajitha Bavanthula , Reddy Penthala Narsimha , Kumar Buridapad Sunil , Srinivasulu Neeladri , Reddy Yerram Reddy Thirupathi
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Preparation of Vinylphenols from 2‐ and 4‐Hydroxybenzaldehydes.
Authors: Simpson Carol J. , Fitzhenry Matthew J. , Stamford N. Patrick J.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
A New Method for the Synthesis of Cinnamonitriles by Catalytic Olefination.
Authors: Nenajdenko V. G. , Golubinskii I. V. , Lenkova O. N. , Shastin A. V. , Balenkova E. S.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
CeCl3×7H2O‐KI‐Catalyzed Environmentally Friendly Synthesis of N,N′‐Disubstituted Ureas in Water under Microwave Irradiation.
Authors: Li Zheng , Wang Zhi‐Yuan , Zhu Wei , Xing Yu‐Lin , Zhao Yan‐Long
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Radical Cyclization in Heterocycle Synthesis. Part 15. Relationship Between a Radical Species and Radical Acceptors of Three Different Types of Double Bond in Radical Addition—Cyclization.
Authors: Miyata Okiko , Kajisa Seiko , Ueda Masafumi , Yamauchi Masashige , Naito Takeaki
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Heteropolyacid‐Catalyzed Reaction of Epoxides with Ketones: Efficient Synthesis of 1,3‐Dioxolane Derivatives.
Authors: He Jun‐Yi , Gao Fei‐Xue , Hua Rui‐Mao
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Rapid One‐Pot Preparation of 2‐Substituted Benzimidazoles from 2‐Nitroanilines Using Microwave Conditions.
Authors: VanVliet David S. , Gillespie Paul , Scicinski Jan J.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
An Efficient Approach to the Synthesis of 3‐Vinylidene Tetrahydropyrans via Prins‐Type Cyclization.
Authors: Dziedzic Magdalena , Lipner Grzegorz , Furman Bartlomiej
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Pyrrolocoumarins. Part 1. Synthesis and Spectroscopic Investigation of 7‐Oxo‐ and 1,2,7‐Trioxo‐1,2‐dihydropyrano[3,2‐e]indole and Their Derivatives.
Authors: Khoshtariya T. E. , Kurkovskaya L. N. , Bochoidze L. T. , Batsikadze K. T. , Mirziashvilli N. T. , Abesadze I. G. , Sikharulidze M. I. , Turabelidze V. G. , Ananiashvili V. O. , Dzhashi T. O. , et al. et al.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Cyclohexenyl‐ and Dehydropiperidinyl‐alkynyl Pyridines as Potent Metabotropic Glutamate Subtype 5 (mGlu5) Receptor Antagonists.
Authors: Chua Peter C. , et al. et al.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Vilsmeier—Haack Reagent: A Facile Synthesis of 2‐Chloro‐3‐formylquinolines from N‐Arylacetamides and Transformation into Different Functionalities.
Authors: Srivastava Ambika , Singh R. M.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Development of an Oxazolopyridine Series of Dual Thrombin/Factor Xa Inhibitors via Structure‐Guided Lead Optimization.
Authors: Burgey Christopher S. , et al. et al.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
The Synthesis of 2‐(1,2,3‐Triazol‐2‐yl)‐1,8‐naphthyridines under Microwave Irradiation.
Authors: Mogilaiah Kaleru , Prashanthi Mullangi , Kavitha Siddoju , Reddy Nagavelli Vasudeva
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Heterocycles with a Bridgehead Nitrogen Atom. Part 16. Assembly of a peri‐Fused System from an Angular Tricycle by Recyclization of an Oxazole Ring into Pyrrole One.
Authors: Babaev E. V. , Tsisevich A. A. , Al'bov D. V. , Rybakov V. B. , Aslanov L. A.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Highly Efficient One‐Pot Synthesis of 1‐Substituted‐1,2,3,4‐tetrahydropyrazino[1,2‐a]indoles.
Authors: Tiwari Rakesh K. , Singh Jaspal , Singh Devender , Verma Akhilesh K. , Chandra Ramesh
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
New Derivatives of 3,4‐Polymethylene‐1,2,4‐benzothiadiazine S,S‐Dioxides.
Authors: Nazarenko K. G. , Shirokaya T. I. , Tolmachev A. A.
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Application of Palladium‐Catalyzed Amination to the Synthesis of Polyazamacrocycles Containing 3,5‐Disubstituted Pyridine.
Authors: Beletskaya Irina P. , Averin Alexei D. , Ulanovskaya Olesya A. , Fedotenko Ilya A. , Borisenko Anatolii A. , Serebryakova Marina V. , Denat Franck , Guilard Roger
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Generation of 9‐Stannaphenanthrene and Its Reactivities.
Authors: Mizuhata Yoshiyuki , Takeda Nobuhiro , Sasamori Takahiro , Tokitoh Norihiro
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Two New Benzoquinone Derivatives and Two New Bisorbicillinoids Were Isolated from a Marine‐Derived Fungus Penicillium terrestre.
Authors: Liu Weizhong , Gu Qianqun , Zhu Weiming , Cui Chengbin , Fan Guotao
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Point Defect Phenomena of Crystalline Structure in Some Common Structural Materials
Authors: Ruan Yu‐Zhong , Wu Ren‐Ping , Yu Yan
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Ruthenium Vinylidene Complexes: Syntheses and Applications in Metathesis Catalysis
Authors: Dragutan Valerian , Dragutan Ileana
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
The Furan‐2(5H)‐ones: Recent Synthetic Methodologies and Its Application in Total Synthesis of Natural Products
Authors: De Souza Marcus Vinicius Nora
Published: December 2005

For Abstract see ChemInform Abstract in Full Text.
Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy
Authors: Borthakur Gautam , Kantarjian Hagop , Daley George , Talpaz Moshe , O'Brien Susan , Garcia‐Manero Guillermo , Giles Francis , Faderl Stefan , Sugrue Mary , Cortes Jorge
Published: December 2005

BACKGROUND

Lonafarnib (SCH66336) is a nonpeptidomimetic farnesyl transferase inhibitor that has demonstrated significant preclinical activity against chronic myelogenous leukemia (CML) cells and in CML animal models.

METHODS

In the current study, the efficacy of lonafarnib was investigated in patients with CML in the chronic or accelerated phase that was resistant or intolerant to imatinib. Thirteen patients with CML in the chronic (n = 6 patients) or accelerated (n = 7 patients) phase were treated with lonafarnib at a dose of 200 mg orally twice daily. Ten patients had failed therapy with imatinib and 3 patients were intolerant to imatinib. The median age of the patients was 62 years (range, 38–80 yrs) and the median time from the diagnosis of CML to therapy with lonafarnib was 5 years (range, 0.3–13 yrs). In addition to imatinib mesylate, all patients had received prior therapy with interferon‐α and seven patients had received other treatments. The median duration of therapy with lonafarnib was 8 weeks (range, 2–41 wks).

RESULTS

Two patients responded. One patient in the accelerated phase of CML returned to the chronic phase, a response that lasted for 3 months. Another patient with chronic phase disease had lowering of the leukocyte count without the need for hydroxyurea and normalization of the differential count that lasted for 5 months. The most common adverse event was diarrhea, which was noted in 11 patients (84%) (Grade ≥ 3 in 4 patients; 31%; toxicity was graded according to the National Cancer Institute Common Toxicity Criteria [version 2.0]). Therapy was discontinued in one patient because of diarrhea not responding to dose adjustments.

CONCLUSIONS

Single‐agent lonafarnib appears to have clinical activity in a small proportion of patients with CML refractory to imatinib. Cancer 2006. © 2005 American Cancer Society.
On using BPEL extensibility to implement OGSI and WSRF Grid workflows
Authors: Slomiski Aleksander
Published: December 2005

This paper discusses the benefits and challenges of using BPEL4WS in Grid environments. In particular, we look at how BPEL4WS built‐in extensibility can be used to facilitate execution of BPEL‐based workflows in OGSI‐ and WSRF‐based Grids. Copyright © 2005 John Wiley & Sons, Ltd.
Toward a search architecture for software components
Authors: Silvestri Fabrizio , Puppin Diego , Laforenza Domenico , Orlando Salvatore
Published: December 2005

The Grid and its related technologies enable large‐scale sharing of resources of various types. We envision that in the near future applications will be completely built in a bottom‐up fashion using software components deployed on various locations and interconnected to form a workflow graph. In this paper, we make some proposals on the design of a component search service, enabling users to locate the components they need to deploy an application. Copyright © 2005 John Wiley & Sons, Ltd.
Gene expression profiles in Ciona intestinalis stigmatal cells: Insight into formation of the ascidian branchial fissures
Authors: Shimazaki Aki , Sakai Akiko , Ogasawara Michio
Published: December 2005

Gill slits, a series of openings in the pharyngeal epithelium, are characteristic features of the hemichordate and chordate body plans. In ascidians, these openings, called stigmata, are formed in the branchial sac during juvenile development. Multiple whole‐mount in situ hybridization analyses based on approximately 1,500 genes expressed in Ciona intestinalis juveniles, identified 28 genes expressed predominantly in the stigmatal cells. Expression patterns of these stigmatal genes were classified into four different categories. On the basis of these findings, we have been able to show that the peripheral region of a stigma consists of at least three different regions. The expression of a Dlk1‐like gene was detected in nonciliated cells during the stigma perforation and division and was maintained in the basal region of the elliptical stigma. Expression of meichroacidin, tektin A1, and tektin B1 orthologs during the differentiation of the ciliated stigmatal cells suggests that some of the molecular mechanisms involved in sperm differentiation might be recruited for the stigma development, or vice versa. Components of the cilia such as alpha‐tubulin and rootletin were also expressed in the stigmatal cells. These genes might facilitate further analyses regarding the evolution of the branchial fissures and the development of the ascidian stigmata. Developmental Dynamics 235:562–569, 2006. © 2005 Wiley‐Liss, Inc.
A New Infrared Spectroelectrochemical Cell for the Detection of Species Generated by Platinum and Screen‐Printed Carbon Electrodes
Authors: Shih Wan‐Ying , Yang Jyisy
Published: December 2005

In this paper, we describe a simple and effective infrared (IR) spectroelectrochemical cell for detecting species generated from an electrochemical system featuring low‐IR‐reflectivity electrodes. The IR detection mode of attenuated total reflection (ATR) was employed to construct the spectroelectrochemical cell. Two kinds of electrodes, platinum (Pt) and screen‐printed carbon (SPC), were used to examine the performance of this new cell in detection of electroactive species generated by cyclic voltammetry. Because data generated from highly reflective electrodes are available in the literature, Pt electrode was used to characterize the performances of the developed spectroelectrochemical cell. Results indicated that species generated electrochemically can be observed readily and their responses were comparable to those described in the literature. The cell volume could be lower than 300 μL, which suggests that this approach may be very useful to obtain chemical information during electrochemistry for biological fluids with limited sample volumes. By examining the electrochemical behavior of several amino acids using both Pt and SPC electrodes, the redox behaviors can be readily observed indicating a new spectroelectrochemical cell was successfully developed for the purpose of using of SPC electrode.
17β‐estradiol (βE2) protects human retinal Müller cell against oxidative stress in vitro: Evaluation of its effects on gene expression by cDNA microarray
Authors: Li Chao , Tang Yuhong , Li Feng , Turner Sean , Li Kong , Zhou Xiaohong , Centola Michael , Yan Xiaorong , Cao Wei
Published: December 2005

17β‐estradiol (βE2) is an effective neuroprotectant against hydrogen peroxide (H2O2)‐induced retinal neuronal cell death and light‐induced photoreceptor degeneration. Müller cells are the principal macroglia responsible for supporting retinal neuronal survival, information processing and removing metabolic waste. However, the role of βE2 on human Müller cells is unclear. In this study, the effects of βE2 on human Müller cell survival and gene expression were examined. Our data revealed that βE2 is able to increase human Müller cell viability after exposure to H2O2 through inhibition of apoptosis. Microarray analysis revealed significant changes in the expression of 69 genes (total of 21,324 genes screened) in cultured human Müller cells 6 h after βE2 treatment. Four of the βE2‐responsive genes [thrombospondin 1 (TSP1), mitogen‐activated protein kinase kinase kinase 3 (MAP3K3), large conductance calcium‐activated potassium channel β2 subunit (KCNMB2), and SRY (sex‐determining region Y)‐box 11 (SOX11)] were validated by both real‐time qRT‐PCR and semi‐quantitative RT‐PCR. Interestingly, exposure of human Müller cells to βE2 increased pigment epithelium‐derived factor (PEDF) gene expression as measured by both RT‐PCR and real time qRT‐PCR. Our data demonstrate, for the first time, that βE2 protects cultured human Müller cells against H2O2‐induced cell death through the inhibition of apoptosis. This protective effect may operate through regulation of genes, such as TSP1, MAP3K3, SOX11, TSP1, and PEDF, and may in turn exert an important role in protecting retinal neurons. © 2005 Wiley‐Liss, Inc.
Risk of second cancer among women with breast cancer
Authors: Mellemkjær Lene , Friis Søren , Olsen Jørgen H. , Scélo Ghislaine , Hemminki Kari , Tracey Elizabeth , Andersen Aage , Brewster David H. , Pukkala Eero , McBride Mary L. , Kliewer Erich V. , Tonita Jon M. , Kee‐Seng Chia , Pompe‐Kirn Vera , Martos Carmen , Jonasson Jon G. , Boffetta Paolo , Brennan Paul
Published: December 2005

A large number of women survive a diagnosis of breast cancer. Knowledge of their risk of developing a new primary cancer is important not only in relation to potential side effects of their cancer treatment, but also in relation to the possibility of shared etiology with other types of cancer. A cohort of 525,527 women with primary breast cancer was identified from 13 population‐based cancer registries in Europe, Canada, Australia and Singapore, and followed for second primary cancers within the period 1943–2000. We used cancer incidence rates of first primary cancer for the calculation of standardized incidence ratios (SIRs) of second primary cancer. Risk of second primary breast cancer after various types of nonbreast cancer was also computed. For all second cancer sites combined, except contralateral breast cancer, we found a SIR of 1.25 (95% CI = 1.24–1.26) on the basis of 31,399 observed cases after first primary breast cancer. The overall risk increased with increasing time since breast cancer diagnosis and decreased by increasing age at breast cancer diagnosis. There were significant excesses of many different cancer sites; among these the excess was larger than 150 cases for stomach (SIR = 1.35), colorectal (SIR = 1.22), lung (SIR = 1.24), soft tissue sarcoma (SIR = 2.25), melanoma (SIR = 1.29), non‐melanoma skin (SIR = 1.58), endometrium (SIR = 1.52), ovary (SIR = 1.48), kidney (SIR = 1.27), thyroid gland (SIR = 1.62) and leukaemia (SIR = 1.52). The excess of cancer after a breast cancer diagnosis is likely to be explained by treatment for breast cancer and by shared genetic or environmental risk factors, although the general excess of cancer suggests that there may be additional explanations such as increased surveillance and general cancer susceptibility. © 2005 Wiley‐Liss, Inc.
Embryonic inner ear cells use migratory mechanisms to establish cell patterns in vitro
Authors: Bianchi Lynne M. , Huri Daniel , White Ian O.
Published: December 2005

The hair cells of the sensory epithelium in the inner ear are among the most precisely organized cells in vertebrates. The mechanisms that lead to this orderly arrangement are only beginning to be understood. It has been suggested that hair cells use migratory mechanisms to help achieve their final position in the organ of Corti. The small size and complex organization of the intact inner ear have made it difficult to monitor changes in hair cell location over time in vivo. In the present study, an established in vitro assay of dissociated, embryonic inner ear cells was used to monitor how hair cells reorganize over time. The hair cell specific marker myosin‐VI demonstrated that hair cell precursors from both cochlear and vestibular regions reorganized into specific patterns between 3–24 hr in vitro. In contrast to the unlabeled cells, the myosin‐VI‐positive cells extended processes while establishing the hair cell patterning within an aggregate. These studies support the hypothesis that hair cell precursors actively migrate to help achieve final patterning within the inner ear sensory epithelium. © 2005 Wiley‐Liss, Inc.
Increased expression of matrix metalloproteinase‐2 and 9 and human papilloma virus infection are associated with malignant transformation of sinonasal inverted papilloma
Authors: Katori Hideaki , Nozawa Akinori , Tsukuda Mamoru
Published: December 2005

Background and Objectives

In this study, we identified matrix metalloproteinase (MMP)‐2 and 9 expression in exophytic papilloma (EP), inverted papilloma (IP) with dysplasia, IP with carcinoma, and invasive squamous cell carcinoma (SCC). We also compared the presence of MMP‐2 and 9 with human papilloma virus (HPV) infection.

Methods

The nasal tissue were stained with monoclonal antibodies to MMP‐2 and 9. The results were analyzed using quantitative immunohistochemical analysis. In situ hybridization studies for HPV DNA for 6/11, 16/18, and 31/33 were also performed on the tissue.

Results

Significant increase of MMP‐2 and 9 were observed in IP with moderate and severe dysplasia, IP with carcinoma, and invasive SCC compared to control nasal mucosa. Among IP, HPV 6/11‐positive was present in 41% and HPV 16/18‐positive was present in 31%. In HPV 6/11 and 16/18‐positive IP, significant increase of MMP‐2 and 9 were observed.

Conclusions

Precancerous lesions of IP exhibited elevated levels of MMP‐2 and 9 and these expression may be associated with early events in IP carcinogenesis. HPV infection would be an early event in a multistep process of malignant formation of IP. J. Surg. Oncol. 2006;93:80–85. © 2005 Wiley‐Liss, Inc.
Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C
Authors: Ogata Yutaka , Matono Keiko , Sasatomi Teruo , Ishibashi Nobuya , Torigoe Shojiro , Fukumitsu Takamasa , Mizobe Tomoaki , Yamashita Natsumi , Yanagawa Takashi , Shirouzu Kazuo
Published: December 2005

Background and Objectives

We have investigated the regulation by mitomycin C (MMC) of thymidine phosphorylase (dThdPase) and dihydropyrimidine dehydrogenase (DPD), which enhances or reduces the efficacy of capecitabine and its metabolite 5′‐deoxy‐5‐fluorouridine (5′‐DFUR), in rectal cancer tissues.

Materials and Methods

In 31 patients with a rectal cancer, tumor biopsies were performed before and after pre‐operative venous administration of 4 mg/m2, 6 mg/m2, or 10 mg/m2 of MMC. The dThdPase and DPD levels in the biopsy and surgical specimens were measured using ELISA, and immunostaining for dThdPase was performed.

Results

The fitting multiple linear regression models indicated that the dThdPase levels increased after MMC administration, in particular in the patients with a pre‐treatment dThdPase level less than 56.2 U/mg protein (median value). The time course analysis indicated that the increase in the dThdPase level by 4 mg/m2 of MMC administration continued for 3 weeks. The dThdPase/DPD ratio was increased after MMC administration in patients with a pre‐treatment dThdPase/DPD ratio less than 1.79 (median value). MMC enhanced the expression of dThdPase protein both in the tumor cells and in the stromal cells. The disease free‐survival rate in the Dukes B or C patients with a high dThdPase/DPD ratio in surgical specimen who received 5′‐DFUR based adjuvant chemotherapy tended to be higher than that in those with a low dThdPase/DPD ratio.

Conclusion

MMC may upregulate the dThdPase level and the dThdPase/DPD ratio in rectal cancer tissues. Combined use of MMC with capecitabine or 5′‐DFUR may offer a more effective colorectal cancer therapy. J. Surg. Oncol. 2006;93:47–55. © 2005 Wiley‐Liss, Inc.
Expression of telomeric repeat binding factor 1 in non‐small cell lung cancer
Authors: Hu Jian , Sun Li , Zhang Chong , Zhou Xielai
Published: December 2005

Background and Objectives

Telomeric repeat binding factor 1 (TRF1) is crucial for forming and maintaining the protective telomeric structure. However, the relationship between TRF1 and non‐small cell lung cancer(NSCLC) is not well understood. With this background, we investigated the expressions of the mRNA encoded by the TRF1 gene in cancer tissue and the paired non‐cancerous tissue. We also examined whether TRF1 expression is correlated with histopathological features.

Methods

From October 2004 to August 2005, 40 patients with NSCLCs had undergone curative operations, including 29 males and 11 females. There were 20 cases of squamous cell carcinoma and 20 cases of adenocarcinoma. We measured the expression of TRF1 mRNA using RT‐PCR on 40 surgically resected specimens and the paired non‐cancerous tissues.

Results

TRF1 mRNA was significantly downregulated in cancer tissue compared with the paired non‐cancerous tissue. Additionally, the expression of TRF1 mRNA was significantly associated with the grade of tumor differentiation. No significant difference of TRF1 mRNA level was found between sexes, or among different T‐status, clinical stages, pathological subtypes, and lymph node metastasis.

Conclusions

Downregulation of TRF1 mRNA expression appeared in lung cancer tissue. TRF1 may play a significant role in cell differentiation in NSCLC. J. Surg. Oncol. 2006;93:62–67. © 2005 Wiley‐Liss, Inc.
Analysis of isomeric tropane alkaloids from Schizanthus grahamii by very fast gas chromatography
Authors: Bieri Stefan , Muñoz Orlando , Veuthey Jean‐Luc , Christen Philippe
Published: December 2005

This study presents a very fast GC analysis applied for the baseline separation of isomeric tropane alkaloids extracted from the stem‐bark of Schizanthus grahamii (Solanaceae). The work provided a challenging application where isothermal analysis in conjunction with very short narrow bore columns (3 m×100 μm ID and 1.5 m×50 μm ID) was particularly suited for the speeding up. Experimental parameters were used in the optimisation steps, including selection of stationary phase, temperature, internal column diameter and optimal practicable gas velocity. Some considerations about sample injection in fast isothermal analysis are also briefly presented. Finally, the investigated approach allowed a very fast baseline separation of four positional and configurational isomers in less than 9 s.
Prediction of gas chromatographic peak width in capillary columns at different temperatures, carrier gas flows, column lengths, inside diameters and carbon numbers
Authors: Krisnangkura Kanit , Pongtonkulpanich Varaporn
Published: December 2005

Width factor (wf), relative band broadening (br) and retention factor are linearly correlated as ln wf = ln br + ln k [Chromatographia (2002) 56, 99–103]. The k and br are thermodynamic and kinetic energy parameters, and expanded to cover volumetric flow of carrier gas, temperature, phase ratio (β) and carbon number (z). For columns of the same stationary phase and β value but of different lengths, width at base (wb) can be predicted with the same numerical values of the constants. The average absolute differences between predicted and experimental wb for BP‐1 columns of 30, 20 and 10 m are 1.27%, 1.21% and 1.37%, respectively. In predicting wb of n‐alkanes eluted from columns of the same stationary phase but of different ID, only the differences of ln β are required for adjustment of one of the numerical values. The average absolute differences between wb (cal) and wb (exp) values for columns of 0.53, 0.32, 0.22 and 0.15 mm ID are 2.06, 3.67, 3.82 and 3.47%, respectively.
Determination of phenol in landfill leachate by using microchip capillary electrophoresis with end‐channel amperometric detection
Authors: Wu Youyi , Lin Jin‐Ming
Published: December 2005

Phenol, 2,4‐dichlorophenol (2,4‐DCP), and 2,4,6‐trichlorophenol (2,4,6‐TCP) were baseline separated by using a homemade microchip CE with an end‐channel amperometric detector where a 50 μm Pt microdisk working electrode (WE) and a Pt cathode were integrated onto the microchip itself. Separation parameters such as injection time and voltage, pH of the buffer, online pretreatment condition for WE, reproducibility, and detection potential were investigated. Under the selected separation conditions, the linear ranges for phenol, 2,4‐DCP, and 2,4,6‐TCP were 2–200, 4–400, and 4–400 μM, respectively. The LODs were 0.4, 0.5, and 0.7 μM for phenol, 2,4‐DCP, and 2,4,6‐TCP, respectively (S/N = 3). The standard addition method was successfully applied to the analysis of landfill leachate samples and the concentration of phenol in the landfill leachate samples was measured to be 0.32 and 0.21 mM, respectively. The recoveries were in the range of 85–103% and corresponding RSDs were less than 5.5%.
Distributional radius of curvature
Authors: Estrada Ricardo
Published: December 2005

We show that any continuous plane path that turns to the left has a well‐defined distribution that corresponds to the radius of curvature of smooth paths. We show that the distributional radius of curvature determines the path uniquely except for a translation. We show that Dirac delta contributions in the radius of curvature correspond to facets, that is, flat sections of the path, and show how a path can be deformed into a facet by letting the radius of curvature approach a delta function. Copyright © 2005 John Wiley & Sons, Ltd.
Mathematical problems of the theory of elasticity of chiral materials for Lipschitz domains
Authors: Natroshvili David , Stratis Ioannis G.
Published: December 2005

By the potential method, we investigate the Dirichlet and Neumann boundary value problems of the elasticity theory of hemitropic (chiral) materials in the case of Lipschitz domains. We study properties of the single‐ and double‐layer potentials and of certain, generated by them, boundary integral operators. These results are applied to reduce the boundary value problems to the equivalent first and the second kind integral equations and the uniqueness and existence theorems are proved in various function spaces. Copyright © 2005 John Wiley & Sons, Ltd.
Modeling water diffusion anisotropy within fixed newborn primate brain using Bayesian probability theory
Authors: Kroenke Christopher D. , Bretthorst G. Larry , Inder Terrie E. , Neil Jeffrey J.
Published: December 2005

An active area of research involves optimally modeling brain diffusion MRI data for various applications. In this study Bayesian analysis procedures were used to evaluate three models applied to phase‐sensitive diffusion MRI data obtained from formalin‐fixed perinatal primate brain tissue: conventional diffusion tensor imaging (DTI), a cumulant expansion, and a family of modified DTI expressions. In the latter two cases the optimum expression was selected from the model family for each voxel in the image. The ability of each model to represent the data was evaluated by comparing the magnitude of the residuals to the thermal noise. Consistent with previous findings from other laboratories, the DTI model poorly represented the experimental data. In contrast, the cumulant expansion and modified DTI expressions were both capable of modeling the data to within the noise using six to eight adjustable parameters per voxel. In these cases the model selection results provided a valuable form of image contrast. The successful modeling procedures differ from the conventional DTI model in that they allow the MRI signal to decay to a positive offset. Intuitively, the positive offset can be thought of as spins that are sufficiently restricted to appear immobile over the sampled range ofb‐values. Magn Reson Med, 2006. © 2005 Wiley‐Liss, Inc.
Gradient echo acquisition for superparamagnetic particles with positive contrast (GRASP): Sequence characterization in membrane and glass superparamagnetic iron oxide phantoms at 1.5T and 3T
Authors: Mani Venkatesh , Briley‐Saebo Karen C. , Itskovich Vitalii V. , Samber Daniel D. , Fayad Zahi A.
Published: December 2005

Iron oxides are used for cell trafficking and identification of macrophages in plaque using MRI. Due to the negative contrast, differentiation between signal loss caused by iron and native low signal in tissue may be problematic. It is, therefore, preferable to achieve positive contrast. The purpose of this study was to test the efficacy of a new MRI sequence GRASP (GRe Acquisition for Superparamagnetic Particles) to generate a positive signal in phantoms containing iron. Membrane phantoms were constructed containing Ferumoxide at 7 concentrations. Standard GRE sequences were modified with user controlled z‐gradient rephasing (±100%). CNR values were determined as a function of echo time (TE) and % rephasing at 1.5T and 3T. T2* values were determined using multiple double‐echo GRE. The GRASP sequence generated positive signal enhancement in phantoms containing iron. For all rephasing values ≤30%, positive contrast was observed. The CNR generated at 1.5T was greater than the values at 3T for all concentrations tested. Correlation between CNR at 0% and 100% rephasing was observed at 1.5T(R = 0.84). Additionally, correlation between field change across the volume and CNR was observed. In conclusion, GRASP sequences may be used to generate positive signal enhancement in the presence of iron using MRI. Magn Reson Med, 2006. © 2005 Wiley‐Liss, Inc.