bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Family of Selenazolo[3,2-a]pyridinium Derivatives based on Annulation Reactions and Comparative Analysis of Antimicrobial Activity of the Selenium and Sulfur Analogs of Chalcogenazolo[3,2-a]pyridiniums
Authors: Potapov Vladimir A. , Ishigeev Roman S. , Belovezhets Lyudmila A. , Amosova Svetlana V.
Published: September 2024

The synthesis of a novel family selenazolo[3,2-a]pyridin-4-ium derivatives in
high yields was developed based on the annulation reactions of 2-pyridineselenenyl chloride
with unsaturated heteroatom and heterocyclic compounds. The analogous new thiazolo[
3,2-a]pyridin-4-ium derivatives were obtained by the annulation reactions of 2-
pyridinesulfenyl chloride. The reactions with vinylic ethers and N-vinylimidazole gave 3-
substituted selenazolo[3,2-a]- and -[1,3]thiazolopyridin-4-ium derivatives, whereas reactions
with allyl alcohol, allyl chloride, allyl bromide, 3-butenoic, 4-pentenoic and 5-
hexenoic acids occurred with the opposite regiochemistry, affording 2-substituted
[1,3]chalcogenazolo[3,2-a]pyridiniums. The antibacterial activity of the obtained products
against gram-positive and gram-negative bacteria was evaluated, and compounds with high
activity were discovered. A comparison of the antibacterial properties of [1,3]selenazolo[3,2-a]pyridin-4-ium
derivatives with their sulfur analogs shows a higher activity of the selenium compounds.
Study on Shenbao Tablet in Treating Kidney-yang Deficiency Syndromebased on Metabolomics
Authors: Zhou Qing-gang , Han Bao-xia , Yi Huan , Geng Zhao , Gou Xiao-jun
Published: September 2024

Aim:

The aim of this study was to elucidate the mechanism of action of Shenbao tablets
using metabolomics approach.

Background:

Kidney-Yang deficiency is a common syndrome type in traditional Chinese Medicine
(TCM) syndrome typology, closely related to disorders of multiple metabolic pathways and
is the root cause and underlying syndrome type of many diseases. Shenbao tablets can significantly
improve the main symptoms of kidney yang deficiency syndrome, but the mechanism of
action of Shenbao tablets on kidney yang deficiency syndrome is still unknown.

Methods:

The rats were intraperitoneally injected with hydrocortisone once a day for 40 days to
simulate the syndrome. Traditional pharmacodynamic indicators (body mass, biochemical indicators
and pathology) were used to evaluate the efficacy of the medicine. Serum, urine and feces
were collected from rats. UPLC/MS metabolomics method was used to study the overall metabolic
profile of serum, while GC/MS metabolomics method was used to study the metabolic
spectrum of urine and feces.

Results:

Results showed that the syndrome was significantly improved in the treatment group,
and obvious metabolic disorders were observed in rats with the syndrome, with 47 potential biomarkers
identified. Pathway analysis showed that nicotinate and nicotinamide metabolism, glycine,
serine and trione metabolism, aminoacyl tRNA biosynthesis, glycoxylate and dicarboxylate
metabolism were the major ways for Shenbao tablet to improve kidney-yang deficiency syndrome.

Conclusion:

The mechanism of action of Shenbao tablet in improving the syndrome involves the
regulation of energy metabolism, amino acid metabolism, bile acid metabolism, fatty acid metabolism
and intestinal microorganisms. This work shows that metabolomics is a promising tool
for studying the essence of syndrome theory in TCM and the mechanisms of TCM.
The Protective Effect of Astragalus Polysaccharide on Experimental Autoimmune Encephalomyelitis in Mice by Activating the AMPK/JAK/STAT3/Arginase-1 Signaling Pathway
Authors: Wang Jin-Li , Li Bin , He Xue-Xin , Gao Chang-Yu , Wang Jue-Qiong , Guo Ruo-Yi , Fan Jing-Yi , Zhang Ya-Nan , Quan Mo-Yuan , Song Shuang , Xie Tao
Published: September 2024

Objective:

This study aimed to investigate the protective effect and mechanism of
Astragalus polysaccharide (APS) on autoimmune encephalomyelitis.

Methods:

C57BL/6 mice were randomly divided into the blank control group, EAE group, and
APS intervention group (n=15/group). The Experimental Autoimmune Encephalomyelitis (EAE)
mouse model was established by active immunization. The pathological changes in the spinal
cord were evaluated by Hematoxylin-eosin (HE) and Luxol Fast Blue (LFB) staining. The number
of CD11b+ Gr-1+ myeloid-derived suppressor cells (MDSCs) in the spleen tissues of mice in
each group was determined by immunofluorescence staining. The expression of Arginase-1 in
the spinal cord and spleen of each group was detected by immunofluorescence double staining.
The TNF-α, IL-6, and Arginase-1 levels in the spleen were detected by ELISA assay. A western
blot was used to detect the protein expression of the AMPK/JAK/STAT3/Arginase-1 signaling
pathway.

Results:

After the intervention of APS, the incidence of autoimmune encephalomyelitis in mice
of the APS group was significantly lower than that in the EAE group, and the intervention of
APS could significantly delay the onset time in the EAE mice, and the score of neurological
function deficit in mice was significantly lower than that in EAE group (P < 0.05). APS intervention
could reduce myelin loss and improve the inflammatory response of EAE mice. Moreover,
it could induce the expression of CD11b+ GR-1 + bone MDSCs in the spleen and increase
the expression of Arginase-1 in the spinal cord and spleen. This study further demonstrated that
APS can protect EAE mice by activating the AMPK/JAK/STAT3/Arginase-1 signaling pathway.

Conclusion:

After the intervention of APS, myelin loss and inflammatory response of EAE mice
were effectively controlled. APS promoted the secretion of Arginase-1 by activating MDSCs and
inhibited CD4+T cells by activating AMPK/JAK/STAT3/Arginase-1 signaling pathway, thus
improving the clinical symptoms and disease progression of EAE mice.

conclusion:

The EAE animal model was established successfully. After the intervention of APS, myelin loss and inflammatory response of EAE mice were effectively controlled. APS promoted the secretion of Arginase-1 by activating MDSCs and inhibited CD4+T cells by activating AMPK/JAK/STAT3/Arginase-1 signaling pathway, thus improving the clinical symptoms and disease progression of EAE mice.
Exploring Phytochemical Compounds: A Computational Study for HIV-1 Reverse Transcriptase Inhibition
Authors: Bandi Jyotsna , Chunduru Madhan , Mangamuri Satya Tulasi , Nelapati Anand Kumar , Naravula Jalaja , Mulpuru Viswajit
Published: September 2024

Background:

HIV-1 is the most virulent type, causing most AIDS cases worldwide.
Therapeutics like NRTIs and NNRTIs terminate replication by terminating polymerization reactions.
Natural-based therapeutics are increasingly being used to reduce side effects and combat disease.

Method:

The study focuses on identifying phytochemical compounds that effectively inhibit the
HIV-1 reverse transcriptase process using molecular docking and molecular dynamic simulations.

Result:

Molecular docking results show anisomelolide has a significantly stronger binding affinity
(-29.9992KJ/mol) compared to nevirapine (-13.34696 KJ/mol), forming more hydrogen bonds and
hydrophilic interactions, indicating a more stable and specific binding. MD simulations further
support these findings, with anisomelolide exhibiting lower RMSD and RMSF values, suggesting
greater structural stability and lower flexibility. Interaction energy analysis reveals robust binding
and stability for anisomelolide over time. Additionally, hydrogen bond analysis indicates more frequent
and stronger interactions for anisomelolide.

Conclusion:

The phytochemical compound anisomelolide exhibits superior binding affinity, structural
stability, and interaction dynamics, making it a promising candidate for drug development
against HIV-1 RT.
Boosting Water Remediation Processes by Exploring the Role of Carbonaceous Material in Advance Oxidation and Adsorption Processes
Authors: Kumari Suman , Devi Sushma , Kumar Ajay
Published: September 2024

In recent decades, considerable attention has been directed toward
wastewater remediation through various processes, including adsorption, advanced
photo-reduction/oxidation processes, ion exchange, and more. The linchpin of these
processes lies in the judicious selection of appropriate materials, capable of not only
meeting the primary requirements but also exhibiting suitable availability. The
exploration of carbonaceous materials such as activated carbon, biochar, hydrochar,
etc., emerges as a cost-effective strategy for wastewater remediation. The surface area,
a well-established pivotal factor, assumes a critically influential role in the wastewater
remediation process. Therefore, it is paramount, during the fabrication of such
materials, to adopt appropriate strategies to ensure the fulfillment of the targeted
material requirements. Due to their extensive surface area, carbonaceous materials hold
immense potential in wastewater treatment through advanced oxidation processes
(AOPs). The efficacy of these AOPs, encompassing photo-catalysis and photoreduction/oxidation, hinges upon the materials employed, including nanoparticles and
hetero-structures. In turn, all AOPs are orchestrated by reactive oxidation species
(ROS) generated at the active sites of catalysts, such as nanoparticles and heterostructures. This study comprehensively summarizes the pivotal role of carbonaceous
materials, underscores their significance, and elucidates the fabrication techniques
essential for their multidisciplinary application in wastewater treatment processes.
THE CORRELATION BETWEEN ADENOID, TONSIL SIZE, AND BODY MASS INDEX WITH OBSTRUCTIVE SLEEP APNEA SEVERITY IN PEDIATRIC PATIENTS
Authors: Murdiyo Mohammad Dwijo , Christianty Finna , Leonard Aditya
Published: September 2024

Background: Sleep disturbance in pediatrics produce daytime sleepiness and decrease productivity. Obstructive sleep apnea (OSA) was the most common cause of daytime sleepiness in children. Adenoid and tonsil hypertrophy was a major determinant of OSAS in pediatrics, in addition to other disorders such as craniofacial anomalies and obesity. Understanding the correlation between adenoid, tonsil size and body mass index (BMI) can be useful in managing optimal treatment strategies. Objective: To examine the correlation between adenoid, tonsil size, and BMI with OSA severity in pediatric patient with OSAS. Methods: The medical records of the Department of Otorhinolaryngology Head and Neck Surgery were utilised for this retrospective cross-sectional study spanning from January 1, 2016 to December 31, 2018. This research comprised a cohort of nineteen patients in total. The medical record was queried for the patient's age, sex, adenoid, and tonsil dimensions. The results of a pre-operative polysomnography to assess the severity of OSA were obtained as part of a routine examination and documented in the patient's medical records. Results: The correlation between variables showed in crosstabulation and Scatter Plot. A p-value below 0.05 indicated that the correlation coefficient of -0474 between adenoid size and OSA severity was statistically significant. The correlation between tonsil size and the severity of obstructive sleep apnea (OSA) was not statistically significant (R2 < 0.3, p < 0.05). Similarly, the correlation between BMI and OSA severity showed no significancy with p-value > 0.05, respectively. Conclusion: Adenoid size measured with Cohen and Konak ratio show significant correlation with OSA severity. While tonsil size and BMI showed no significancy in OSA severity.
ANGIOPLASTIC STENOSIS IN SPONTANEOUS BILATERAL CAROTIC ARTERY DISSECTION: A CASE REPORT
Authors: Subandi Subandi , Danuaji Rivan , Suroto Suroto , Mirawati Diah Kurnia , Budianto Pepi , Hambarsari Yetty , Hamidi aarid Luqman , Prabaningtyas Hanindia Riani , Hutabarat Ervina Arta Jayanti , Ristinawati Ira , Tejomukti Teddy , Tedjo Raden Andi Ario , Santosa Novian Anindito , Putra Stefanus Erdana , Hafizhan Muhammad
Published: September 2024

Case: A 28-years-old woman presented with sudden right extremities weakness, right sided facial droop, and not being able to speak. On examination, the patient had upper motor neuron (UMN) hemiplegia and motor aphasia. On blood laboratory, we found D-dimer level of 1068 ng/dl. A non-contrast head CT-scan and CT-angiography showed left cerebral hemisphere infarction, and bilateral carotid artery stenosis. Further investigation with transcranial Doppler demonstrated partial stenosis of internal carotid artery (ICA). On cerebral digital subtraction angiography (DSA), we observed pseudoaneurysm on the right ICA and flame-shaped appearance on the left ICA, both are common radiological finding of ICA dissection. Then we performed stenting angioplasty on bilateral ICA to provide recanalization, and aspirin 80mg q.d. and clopidogrel 75mg q.d. was initiated. Conclusion: Spontaneous dissection of the carotid artery can occur on young adults. DSA is considered as the gold standard for vascular examination, and stenting with angioplasty was performed for recanalization to prevent the progression to severe stroke.
EVALUATION OF THE OPTIC NERVE IN MIGRAINE PATIENTS BY MAGNETIC RESONANCE IMAGING HISTOGRAM ANALYSIS
Authors: Kara Turgay , Dogan Adil , Baykara Murat , Yıldız Cemile Buket Tugan , Tural Ibrahim Cagri
Published: September 2024

Background: Migraine is a chronic, paroxysmal neurovascular primary headache disease seen in approximately 15% of the world. In many studies on migraine, changes in the gray and white matter at the microvascular level have been detected. 90% of patients with aura have visual auras. Histogram analysis is an artificial intelligence application that can detect microscopic pathology in tissues before visual pathology. Objective: Histogram analysis was utilized in our investigation to ascertain whether or not the optic nerve, which is ordinarily visible on magnetic resonance images, was impacted. Methods: 120 adult migraine patients and 120 control group were involved. MRI was performed on a Philips 1.5 Tesla Ingenia device. For histogram analysis, optic nerve region of interest (ROI) measurement was performed in the coronal planes from the edges of the intraorbital segment, whose borders can be clearly distinguished, by using the manual drawing tool for both eyes. The data were analyzed through the MatLab program. Results: The average age of individuals diagnosed with migraine was 37.04 ± 9.57 years, whereas the control group had an average age of 37.8 ± 10.8 years. Between the two groups, 27 distinct parameters computed via histogram analysis were compared. In the control and migraine groups, no statistically significant distinction was observed between the right and left eyes. In contrast to the migraine and control groups, the Mean Local Standard Deviation of the Matrix was found to be The histogram's 5th, 10th, 25th, and 75th percentiles, the average squared, the root sum of squared, the size percent M, the most frequently used value, the median, and the average are all quantified using the root sum of squares. The number of pixels is also indicated. It was determined that ROI values were statistically significant (p0.05). Conclusion: In migraine patients, alterations in the optic nerve, which are typically discernible on conventional magnetic resonance images, may be identified via histogram analysis.
Spremnost zdravstvenih ustanova Republike Hrvatske za uključivanje volontiranja
Authors: Šimunković Gordana
Published: September 2024

Volontiranje ima svoj značajni prepoznati doprinos u široj zajednici, ali i u područjima kao što je zdravstveni sustav. Taj doprinos prepoznaje se na razini pacijenta i na razini zdravstvene ustanove, no usprkos tome, zdravstvene ustanove u Republici Hrvatskoj prepoznaju se kao zatvorene za volontiranje. Uz polaznu ideju da je takva zatvorenost poticana niskom razinom spremnosti zdravstvenih ustanova za uključivanje volontiranja, provedeno je istraživanje s ciljem utvrđivanja razine spremnosti zdravstvenih ustanova Republike Hrvatske za uključivanje volontiranja i kreiranja smjernica za pomak spremnosti na višu razinu. Primijenio se mješoviti istraživački pristup koji je obuhvatio provedbu online anketnog istraživanja i provedbu intervjua. Istraživanje se temeljilo na modelu spremnosti zajednice. Anketa je obuhvatila 28,85 % (N = 45) javnih zdravstvenih ustanova, isključujući ljekarničku djelatnost i djelatnost dentalne medicine. Intervjuima je obuhvaćeno vodstvo zdravstvenih ustanova koje uključuju volontiranje (N = 10), djelatnici/ce zdravstvenih ustanova koje uključuju volontiranje (N = 7) i osobe koje volontiraju u zdravstvenim ustanovama (N = 10). Pokazalo se da se zdravstvene ustanove nalaze na razini Slabe svijesti o pojavi (trećoj razini od devet razina spremnosti) s najnižom vrijednosti na dimenziji Resursa. Tematskom analizom praćene su teme prema dimenzijama modela spremnosti zajednice. Kao glavni smjer za pomak na višu razinu spremnosti pokazalo se preuzimanje odgovornosti da se volontiranje kao resurs uključi u pojedinu zdravstvenu ustanovu, što znači preuzimanje stava: „Ovo je važno. Što možemo učiniti?“.
Global Health, Climate Change, and Migration
Authors: Ladas Ioannis
Published: September 2024

This article examines the relationship between global health, climate change, and migration. It explores migration of both humans and animals, and its inverse. Many researchers directly link seasonal droughts, heatwaves, heavy rainfall, and floods to human health, observing, among other things, that these conditions increase contact with wildlife. As a result, there are serious concerns about the risk of future pandemics and epidemics. These issues primarily have a moral dimension because they relate to human well-being and test the fair distribution of healthcare resources. In this context, the development of a new ethic for a truly sustainable environment is deemed necessary, as the protection of the environment and global public health is a global moral responsibility and obligation. Moreover, there is a duty to protect all those displaced by a health crisis due to climate change, and the concept of a type of health asylum could be proposed, as we might soon talk about health refugees and migrants in combination with environmental ones.
Mental Hindrances and Entrepreneurial Supports towards Psychological Wellbeing among Entrepreneurs
Authors: Abdelwahed Nadia A. Abdelmegeed , Ramish Muhammad Sufyan
Published: September 2024

University entrepreneurs' psychological wellbeing (PWB) is a gigantic problem that substantially affects their academic performance, health, innovative capabilities, and more comprehensive societal contributions. In this study, we examine mental hindrances, such as stress, anxiety and depression and entrepreneurship-related constructs, such as entrepreneurial purpose (ENSE), entrepreneurial carefulness (ENSS) and entrepreneurial desire (ENRE) that predict PWB among Egyptian university entrepreneurs. In this quantitative study, we used a questionnaire and a convenience sampling strategy to collect cross-sectional data from Egyptian public-sector university students. In total, we collected 328 cases to infer the results. From applying path analysis through AMOS software, this study’s findings exhibit that mental hindrances, such as stress (β = -0.016; p = 0.187), anxiety (β = -0.055; p = 0.115) and depression (β = -0.027; p = 0.280) have a negative effect on entrepreneurs' PWB. Conversely, this study’s results exert, also, the positive influences that ENSE (β = 0.407; p = 0.000), ENSS (β = 0.0221; p = 0.003), and ENRE (β = 0.145; p = 0.000) have on Egyptian university entrepreneurs' PWB. This study’s outcomes support policymakers and university authorities in shaping strategies to reduce stress and anxiety among Egyptian students and inspire individuals to feel positive emotions. These can lead to initiating good proposals and developing hope. Moreover, this study’s findings provide reassurance and inspiration for Egyptian university entrepreneurs and encourage them to enhance their intentions toward entrepreneurship and, in turn, improve their PWB. Ultimately, this study’s outcomes significantly contribute to the existing literature on this topic.
Implementing an Educational Ecosystem-Centered Approach to the co-creation of a bachelor’s degree in digital health and biomedical Innovation (Preprint)
Authors: Alves Patrícia , Costa Elisio , Costa-Pereira Altamiro , Falcão-Pires Inês , Fonseca João , Leite-Moreira Adelino , Sousa-Pinto Bernardo , Vale Nuno
Published: September 2024

UNSTRUCTURED

This paper aims to describe the co-creation and development processes of an educational ecosystem-centered BSc degree in Digital Health and Biomedical Innovation (SauD InoB). This program is shaped by a multidisciplinary, intersectoral and collaborative framework, involving over 60 organizations in teaching activities and/or internship supervision/hosting, most of which collaborated in needs assessment, curriculum design and public promotion of the degree. In the context of healthcare digital transformation, this comprehensive BSc degree will respond to unmet demands of the labor market by training students with technological, research and management skills, as well as with basic clinical and biomedical concepts. Graduates will become transdisciplinary, creative professionals capable of understanding and integrating different "languages," and reasoning, clinical processes, and scenarios.
Boosting Physical Activity among Individuals with Low Engagement through Double-Point Incentives in a Community-Based mHealth Intervention: A Retrospective Observational Study (Preprint)
Authors: Joo Jungin , Lee Mangyeong , Yoon Junghee , Cho Hyeonjin , Warrier Govind , Thrul Johannes , Cho Juhee
Published: September 2024

BACKGROUND

Community-based mHealth interventions for physical activity are being implemented in many countries; however, maintaining user engagement remains challenging. Therefore, the impact of additional short-term monetary incentives on low-engaged (LE) participants needs to be elucidated as a potential alternative.

OBJECTIVE

This study aimed to evaluate the effectiveness of an additional financial incentive, specifically a double-point event, within a community-based mHealth intervention designed to increase physical activity among individuals with low engagement.

METHODS

Using retrospective data from a Seoul Metropolitan Government mHealth intervention, we evaluated the effects of a one-week double-point incentive on participants’ physical activity. During three registration phases from November to December 2021, 50,145 individuals enrolled. Our analysis focused on the LE group (n=27,833, 55.5%), who averaged fewer than three days per week of meeting the daily step challenge (at least 7,000 steps) before the intervention. We performed a segmented regression analysis to assess changes in physical activity before and after the event. Multivariable logistic regression and Cox proportional hazards models were employed to identify factors associated with improving and maintaining physical activity after starting the intervention.

RESULTS

Out of 27,833 LE participants, only 137% (n=3,835) improved their physical activity. Daily challenge engagements per week increased by 253 times, and average daily steps increased by 192497 (SMD=0.55, 95% CI: 0.51-0.58). In multivariable logistic regression, older age was significantly associated with improved physical activity immediately after starting the intervention. However, 50% of the improved group was likely to return to low engagement three weeks after the intervention ended. Older age and use of certain wearable devices were associated with the maintenance of physical activity after the intervention.

CONCLUSIONS

Double-point incentives in the short term may serve as a cue-to-action to motivate low-engagement targets; however, they do not seem to guarantee long-term maintenance in the context of community-based mHealth interventions. Further research is needed to identify additional strategies beyond monetary incentives to sustain long-term healthy behavior
Compassion Fatigue and Burnout Among Healthcare Professionals:
A Scoping Review Protocol (Preprint)
Authors: CAPOBIANCO SANTOS CHRISTIAN GUILHERME , Fideles Santos Neto Martins , Regina Pedroso Vilela Torres Carvalho Stela , Regina Furlani Márcia , Canato Martins Cíntia , Roberto Santos Emerson , Daniel Souza Menezes João , Querino Silva Matheus , Letícia Santos Loiane , Castro Molina Thaysa , Almeida Arnaldo Silva Rodrigues Castro Natalia , Landim Gonçalves Cristóvão Helena , Santos Júnior Randolfo , Maria Sabadoto Brienze Vânia , Regina Abreu Lima Alba , Silva Fucuta Patrícia , Cristina Móz Vaz Oliani Denise , Aparecida Micelli Domingues Neide , Cristina Oliveira Santos Miyazaki Maria , Maria Araújo Filho Gerardo , César André Júlio
Published: September 2024

BACKGROUND

Compassion fatigue and burnout among healthcare professionals are
growing concerns, impacting the well-being of both providers and patients.

OBJECTIVE

Map existing evidence on the levels of compassion satisfaction, burnout, and
secondary traumatic stress among healthcare professionals, while identifying factors
influencing their professional quality of life.

METHODS

We will conduct a scoping review using established methods and reporting
guidelines. EMBASE, ERIC, PubMed, Science Direct, Scopus, and Web of Science will be
searched from March 2019 to March 2024, with an update closer to the time of
manuscript submission. Grey literature sources will also be searched. Publications that
contain primary studies, systematic reviews, meta-analyses, and clinical guidelines
addressing compassion fatigue and burnout prevention in healthcare professionals will
be selected for inclusion. Extracted data items will include: study characteristics,
interventions for prevention of compassion fatigue and burnout, measures of
compassion satisfaction, burnout, and secondary traumatic stress, as well as quality of
reporting and methodology.

RESULTS

A narrative synthesis with summary tables will be used to describe our
findings.

CONCLUSIONS

Our findings will help identify gaps in the literature with respect to
compassion fatigue and burnout prevention strategies for healthcare professionals. This
review will provide a comprehensive overview of current research, informing future
interventions and policies aimed at improving healthcare professionals' well-being and
job satisfaction

CLINICALTRIAL

[Open Science Framework registration link] (note that information
on this link will be updated upon acceptance for publication based on reviewer
comments).
French adaptation and validation of the User Version of the Mobile Application Rating Scale (uMARS-F) (Preprint)
Authors: Besnier Marc , Tessier Frédéric , Blanchard Clara
Published: September 2024

BACKGROUND

Recently, there is an increasing number of apps developed to help people to adopt correct lifestyles and to help physicians to monitor patients with chronic diseases. Nevertheless, the validity process for measuring and reporting app quality remains unsatisfactory for health professionals and end users and represents a public health concern. While the professional version of the Mobile App Rating Scale (MARS) has already been translated, and validated into the French language, its user-centered counterpart has not yet been adapted.

OBJECTIVE

This study aims to translate, adapt, and validate the equivalent French version of uMARS (uMARS-F).

METHODS

A cross-cultural adaptation, translation, and metric evaluation were performed by native speakers and a translator. The internal consistency and test-retest reliability of the uMARS-F were evaluated using two mHealth app. Both apps were tested by 70 and 72 users and three months later. Paired t-test, Pearson Correlation Coefficient, Intraclass Correlation Coefficient (ICCs) and Cronbach’s Alpha were used to evaluate the reliability and validity of the uMARS-F.

RESULTS

We recruited 142 subjects, distributed between the two apps. All subjects answered all questions both at time 1 and at time 2. Paired t-test showed no statistically significant difference in each answer or group of answers between times 1 and 2 (P > 0.05). Cronbach’s alpha was 0.92, as all subjects answered all questions. Each question was further assessed through the Pearson correlation coefficient, which demonstrated high reliability, with significant P (<0,05) and Pearson Coefficients higher than 0,7. ICCs were higher than 0,75.

CONCLUSIONS

uMARS-F is a valid tool with adequate metric properties to assess the quality of health apps from the user perspective
Fantastic Macrofungi in Poncokusumo District, Bromo Tengger Semeru National Park (TNBTS) Area and Their Habitat Characteristics
Authors: Amelia Aquinita Shinta Setya , Dewi Rosita Fitrah , Setyawati Heni , Hafazallah Khalid , Putrie Rahayu Fitriani Wangsa , Mubarok Husni
Published: September 2024

Bromo Tengger Semeru National Park (TNBTS) is a conservation area in East Java with an abundance of biodiversity, including macrofungi. This study aims to identify the macrofungal species existing in Poncokusumo district, TNBTS area, and their habitat characteristics for a further sustainable study of fungi. This study used a purposive sampling method by opportunistic exploration. Identification of macrofungi is conducted by morphological analysis and habitat characterization. The study identified 15 macrofungal species categorized as Ascomycota and Basidiomycota, that were distinct in their habitat characteristics. The 15 macrofungal species inhabited leaf litter, wood litter, soil, and bamboo.
Effect of Different Concentrations and Combinations of Benzyl Aminopurine and Indole-3-Butyric Acid on Micropropagation of Vanilla Planifolia
Authors: Khun Sokhai , Heng Chenda , Rien Sothea , Rien Sinet , Srean Pao
Published: September 2024

Micropropagation of explants in vitro has potency to address propagule demands for promoting large-scale vanilla production. Plant growth regulators (i.e., cytokinin, auxin) are necessary for the plant micropropagation success. Objective of this study is to determine the shoot multiplication and root development of Vanilla planifolia under the influence of different concentrations and combinations of BA and IBA for micropropagation. Sixty stem nodal segments of Vanilla planifolia were cultured on MS medium supplemented with IBA (0, 0.5, or 2.0 mg/L) and combined with BA (0, 0.5, 1.0, or 2.0 mg/L). Shoot multiplication and root induction were measured after 60 days of culture. The results show that the MS medium with 1 mg/L IBA hindered shoot growth, while the medium containing 1 mg/L BA yielded the highest number or weight of shoots per explant. For the root development, supplementing the medium with 0.5 mg/L or 1 mg/L IBA improved root length or number of roots per explant, respectively. This research establishes a valuable approach for vanilla micropropagation by utilising low concentrations of plant growth regulators and a rapid protocol. This paves the way for significant advancements in large-scale commercial production.
Deep Learning-Based Classification of Fruit Diseases - A Comprehensive Approach to Automated Detection and Diagnosis
Authors: Datta Unmukh
Published: September 2024

This study aims to develop a deep learning-based model for accurate fruit disease classification using advanced architectures like ResNet50 and VGG19. The dataset includes images of fruits such as grapes, mangoes, lemons, pomegranates, and guavas, with both healthy and diseased categories. Diseases like black rot in grapes and bacterial canker in mangoes are considered for classification. The objective is to build a model capable of accurately identifying these diseases to aid in early identification and control. The approach begins with pre-processing the photographs using standardisation, resizing, and data augmentation techniques including flipping, zooming, and rotation to strengthen the model. By enhancing picture contrast with Contrast Limited Adaptive Histogram Equalisation (CLAHE), important illness characteristics can be better highlighted. We train and evaluate deep learning models by dividing the dataset into three parts: training, validation, and test. The ratio of the parts is 80:10:10. According on the results, the ResNet50 model outperforms all other accuracy at 99.77%.
Machine Learning for Improved Detection and Prevention of Credit Card Fraud
Authors: Chauhan Ajay Singh
Published: September 2024

Using machine learning to identify instances of credit card fraud is the primary goal of the research. In order to accomplish this, we will research and assess four distinct classification models: Decision Tree, Logistic Regression, K-Nearest Neighbours (KNN), and Support Vector Classifier (SVC). Included in the Kaggle dataset's "Time," "Amount," and "Class" sections are transaction data points that represent the likelihood of fraud. Disparities in class distribution are a big problem with this dataset, even though 99.83% of the data comes from legitimate transactions. Disparity like this has the potential to lead to biassed model training. We resolved the issue by implementing preprocessing techniques such as feature scaling and resampling. F1-Score, recall, accuracy, and precision are the measures that we use to assess the models. With scores ranging from 93% to 94%, the data demonstrate that all models are incredibly accurate. Having said that, Logistic Regression lacks precision. All things considered, Decision Tree, KNN, and SVC perform very well. The proposed model's accuracy peaked at 94%. As this study demonstrates, thorough evaluation criteria are necessary for finding the optimal model for fraud detection.
Compact Solar Generator with Increased Efficiency
Authors: Singh Shivansh
Published: September 2024

Today the world is moving towards renewable energy. Most important and common form of renewable energy is solar energy. But solar panels have less efficiency and covers more space. This paper discusses about new way of generating electricity with the help of solar panel. A small scale experiment was conducted results have proven good performance. In future this concept will prove a golden change in the life of people.
Could ambidextrous learning improve employees' disruptive innovation behavior? A double-mediation model
Authors: Yang Xiaona
Published: September 2024

This study investigated the influence mechanism of ambidextrous learning on disruptive innovation behavior and the mediating effects of error management climate and creative self-efficacy. I conducted both online and offline surveys with 452 employees in private enterprises, state-owned
enterprises, and institutions. The results indicate that ambidextrous learning predicts employees' disruptive innovation behavior, and both error management climate and creative self-efficacy have significant partial mediating effects on the relationship between ambidextrous learning and disruptive
innovation behavior. This study contributes to ambidextrous learning and disruptive innovation behavior research and advances scholarship into aspects of employees' disruptive innovation behavior in enterprises.
The effect of scientific impact on science communication through art from the lens of deviance theories
Authors: Azagra-Caro Joaquín M. , Pavone Vincenzo
Published: September 2024

Exploring the multifaceted relationship between scientific impact and science communication through art, our study surveys 2,500 Spanish artistic researchers. Guided by deviance theories and double standards theories we reveal a nuanced pattern: the effect of scientific impact initially impedes science communication through art, turning positive after a given impact threshold. Striking a harmonious science-art balance emerges as a mitigating factor, fostering broader links between science communication through art and scientific impact. Our findings advocate for targeted incentives to encourage science communication through art without compromising scientific impact, contributing to a deeper understanding of their complex interplay.
Two Reminiscences from the “Russian Novel” in Marcel Proust’s Essay “Filial Feelings of a Matricide”
Authors:   St. Petersburg State University of Economics, Fokin Sergey L. ,   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences
Published: September 2024

The article aims to follow the complementary methods of the history of concepts and genetic criticism, firstly, to consider in general terms the genealogy of the essay “Filial Feelings of a Matricide,” and secondly, to focus on those of his motifs that could go back to the careful reading of Russian novelists. However, it is important for us not only to provide additional evidence of Proust’s active work with the “Russian Novel,” but also to try to understand from the material of this small but crucial text for the intellectual formation of the novelist how the leading themes of the upcoming novel could be formed, incorporating autobiographical, literary, mythological, psychological, sociological, philosophical motifs. It’s about themes of time and death, crime and redemption, art and life. The analysis suggests that the essay became a kind of trigger for a radical transformation of Proust’s position as a novelist, during which, on the one hand, the fixation on the amateurish autobiography of early creative experiences was overcome. On the other hand, an innovative strategy was tested by using first-person narration, in which the narrator’s “I” acquires partial autonomy from the “I” of the author. Finally, the article concludes that the essay establishes two significant elements of the poetics of the upcoming novel: the lexical and semantic circumscription of the narrative and the “telescopic vision” of reality.
Lyricism: A Free Category or a Relevant Concept in Domestic Literary Criticism?
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Shevchuk, Yuliya V.
Published: September 2024

“Lyrical” / “lyricism” / “lyrical principle” is used as an independent term, in combination with the object of study (prose, cycle, poem) or an adjacent phenomenon (“lyro-epic”) quite widely. Theoretical comprehension and justification of the term “lyricism” remains an undeveloped category in philology. Reflections of domestic researchers on lyrics as a literary genre, practical developments in the analysis of literary works, and the critical development of the problem by the poets themselves allow us to draw some generalizations and conclusions. The article primarily addresses the content and boundaries of the concept of lyrical, which appears as the complex ideological-emotional unity of the author, character, and reader in lyrics and works of synthetic forms. The interaction of subjects (the author and the “other”) occurs in an atmosphere of trusting emotionality of a close situation of confession. The compassionate reader finds himself “inside” the lyrical event, and his dialogue with the author and character has a cathartic outcome. Forms of lyricism in synchrony encapsulate typical traits. Still, to a large extent, they depend on the sense of matter in each particular author, and therefore, in recognized lyricists, they appear as innovations within the traditional literary system. By its nature, lyricism is an intersubject phenomenon, so understanding its forms that convey the general in the spiritual system of generations and masses of people can be promising in diachronia.
“I Choose the Chapter About Protopopov for Testing...” (From the History of A. Blok’s Essay “The Last Days of Imperial Power”)
Authors:   Institute of Russian Literature (Pushkin House) of the Russian Academy of Sciences, Alexandrov Alexandr S.
Published: September 2024

This work is devoted to the fate of the chapter on A.D. Protopopov, chosen by A. Blok as a work, as part of his official activities in the Extraordinary Commission of Inquiry, for reporting to the Constituent Assembly. A wide range of source material (notebooks, diary, letters to his mother) demonstrates Blok’s attitude towards the last Minister of Internal Affairs. The research concerns the poet’s particular focus on the personality of the disgraced official. The article analyzes documents from Blok’s archive related to his work on the chapter and traces Blok’s parallel work on the chapters “The Last Days of the Tsarist Regime” and “Protopopov.” The article presents, among other things, unknown archival materials from the Manuscript Department of the Pushkin House.
The Motif of Mixing Wine and Water in Goliardic Poetry: Genesis and Functions
Authors:   National Research University Higher School of Economics, Dolgorukova Natalia M. , Babenko Kseniia V. ,   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences
Published: September 2024

The article analyses the motif of mixing wine and water in goliardic poetry. The research reveals that this motif has no roots in antique literature but dates back to the patristic tradition of symbolic interpretations of mixing wine and water in the Eucharistic cup. This tradition remained relevant throughout the Middle Ages. Moreover, the theological debate about the real presence of Christ in the Holy Gifts has contributed to the formation of the doctrine of concomitance (the presence of Christ in each of the Holy Gifts), which led to the establishment of the practice of giving communion to the laity in only one form (the Body only). It caused great discontent in the congregation. A reflection of these processes, as we believe, can be found in the poems of goliards. We consider the appearance of the motif in the literature of this period to be part of a literary game, parodia sacra, the essence of which consists in the parodic reversal of Church symbols, texts, and customs (in our case, the profane undiluted wine contrasts with the eucharistic diluted wine) and, on the other hand, a reaction to the changes in the Catholic Rite during this period.
As ondas de rádio e suas regiões midiáticas: as práticas econômico políticas de apropriação dos sinais de radiofrequência no Brasil
Authors:   , Gonçalves Julio Cesar
Published: September 2024

Elaborada na Linha de Pesquisa 2, Mídias e Práticas Socioculturais, do Programa de Pós Graduação em Comunicação e Cultura da Uniso, esta é uma pesquisa empírica e teórica cujo tema é a utilização da radiofrequência do espectro eletromagnético na transmissão dos sinais das emissoras de rádio e TV abertas e gratuitas. A hipótese testada, e confirmada na pesquisa, é a de que a forma de utilização desse recurso natural, a radiofrequência (RF), configura regiões midiáticas definidas pela produção, distribuição e consumo de bens simbólicos no contexto da indústria da comunicação. Dessa forma, o objetivo geral buscou demonstrar a criação de regiões midiáticas, pela distribuição dos sinais de RF e os objetivos específicos tiveram como proposta (1) demonstrar como a RF demarca o território e (2) especificar o papel da indústria da comunicação na regionalização midiática. A pesquisa tem como embasamento teórico o conceito de território de Milton Santos (2001, 2006, 2014), a teoria social da mídia, de John Thompson (1998, 2018) e a regionalização midiáticas no Brasil, de Sonia Aguiar (2016). Recorre-se à análise documental como metodologia, com consultas a fontes primárias e secundárias, e a uma revisão bibliográfica envolvendo, além da Comunicação, áreas de conhecimento como Geografia, Sociologia e Física. E uma das conclusões a que se chegou é que o espectro eletromagnético perdeu seu valor de uso e passou a ter valor de troca para atender à expansão do capitalismo neoliberal. A pesquisa se enquadra na linha de estudo da Economia Política da Comunicação e espera contribuir com o despertar de mais interesse pela inclusão de aspectos relacionados à infraestrutura nos debates sobre a democratização das comunicações no Brasil.
The Site of Protonation Affects the Dissociation of Protonated a- and b-Pinene Ions
Authors: Buenger Edgar White , Mayer Paul
Published: September 2024

The unimolecular reactions of protonated α- and β-pinene ions were
explored with a combination of collision-induced dissociation tandem
mass spectrometry and theory. The two main dissociation reactions in
each ion lead to the losses of neutral propene and isobutene. The
difference observed between the two ions is a greater relative abundance
of propene loss in the case of protonated a-pinene. Both ions were found
to dissociate over the same minimum energy reaction pathway, the only
difference being the site of initial protonation in the two ions.
a-Pinene preferentially protonates at the bridging carbon, while
b-pinene can only significantly protonate at the exocyclic double bond.
This leads to a lower appearance energy for loss of isobutene, and thus
relatively greater m/z 81 fragment ion abundance for b-pinene.
Towards a survival-based cellular assay for rapid selection of protease inhibitors
Authors: Oyadomari William , Carvalho Elizangela , Machado Gabriel , Machado Ana Júlia , Santos Gabriel , Marcondes Marcelo , Oliveira Vitor de
Published: September 2024

We are describing a method tailored for in-cell selection of protease
inhibitors. In this method, a target protease is co-expressed with a
selective substrate, the product of which kills the host cells.
Therefore, it can be applied to identify potential inhibitors, based on
cell host survival, when inhibition of the target protease occurs. The
method would be suitable for selection of inhibitors from
intracellularly generated inhibitor libraries, like SICLOPPS, for
instance. TEV protease was chosen for this proof-of-concept. The
genetically encoded selective substrate is a single polypeptide chain,
composed of three parts: (1) ccdB protein that can cause host cell death
when it accumulates inside cell, (2) a protease cleavage sequence, that
can be changed according to the target protease: ENLYFQG sequence for
TEV substrate ( - predicted cleavage site) and (3) the ssrA sequence
(AANDENYALAA), which drives the polypeptide to degradation by the
ClpX/ClpP complex inside host E. coli cells. Conditions for controlled
expression of this substrate, in which its steady-state concentration
did not provoke significant death of host cells, were established.
Co-expression of active TEV protease and this selective substrate
(ccdB-ENLYFQG-ssrA) caused the death of a significant host cell
population, while control assays with an inactive mutant TEV Asp81Asn
did not. Details of the methodology used are given, providing the basis
for the application of similar systems for other proteases of interest.
GOLPH3-STIP1 Complex Activates STAT3 through Exosome Secretion to Induce Colon Cancer Metastasis
Authors: Guo Yanta , Hong Zhongshi , Huang Sifu , Wu Yuze , Qiu Chengzhi , Xu Jianhua
Published: September 2024

Background: The functions of GOLPH3, STIP1, and the STAT3 signaling
pathway in the invasion and migration of CC cells were examined in this
study. Method: High-speed centrifugation was used to collect the
exosomes. The expression of GOLPH3, STIP1, and epithelial-mesenchymal
transition (EMT)-related proteins in CC tissues, cells, and exosomes
were analyzed using Western blotting (WB) experiments. The abilities of
CC cell invasion and migration were evaluated by the Transwell assay.
The binding relationship between GOLPH3 and STIP1 was validated through
Co-immunoprecipitation (Co-IP), and their sublocalization in CC cells
was determined by immunofluorescence detection under laser confocal
microscopy. Immunohistochemistry (IHC) experiments detected the
expression levels of each protein in the transplanted tumor mass. Animal
experiments confirmed the impact of the GOLPH3/STIP1/STAT3 regulatory
axis on the CC growth. Results: In CC tissues and cells, GOLPH3 was
highly expressed, and silencing GOLPH3 not only greatly reduced CC cell
invasion and migration but also prevented EMT. Furthermore, GOLPH3 and
STIP1 interacted in CC cells, and the GOLPH3-STIP1 complex affected the
capacity for cell invasion and migration by triggering the STAT3
signaling pathway. Noteworthily, GOLPH3, and STIP1 could also be
detected in CC cell exosomes, and the exosomes carried the GOLPH3-ST1P1
complex to act on CC cells to activate intracellular STAT3 signaling,
ultimately affecting the cancer cell migration and invasion. The above
molecular regulatory mechanisms have also been validated in mice.
Conclusion: The GOLPH3-STIP1 complex acted on surrounding CC cells
through exosomes and activated the STAT3 signaling pathway to stimulate
CC cell invasion and migration