bluuebunny/crossref_metadata_2025 huggingface dataset:
Complex Function-Based Fault Detection: A New Method to Measure the Complexity of Nonlinear Time Series
Authors: Song Yangyang , Feng Guochen
Published: July 2024

In this paper, we propose a new complexity computation based on the complex function. This measure exploits the dispersion Lempel–Ziv complexity (DLZC) and the dispersion statistical complexity measure based on Jensen–Shannon divergence (DCJS) of the analytic signal and constructs the binary complex function, called complex number complexity (CNC). The statistical measure depicts the complex system from different angle and mines more potential information. Through simulation experiments, we prove that the proposed method is able to detect data fluctuations more sensitively and accurately. For an application, the CNC is applied to fault detection which has different fault diameters and rotational speeds. The results deliver that the CNC measure can well represent the complexity of faulty bearings and has significant differences in any two fault types. The technique is effective to characterize different fault.
New Insights into Domestic Price Drivers of Crude Oil Futures Markets: Evidence from Quantile ARDL Approach
Authors: Shao Hao-Lin , Shao Ying-Hui , Yang Yan-Hong
Published: July 2024

This paper investigates the asymmetric cointegration between possible domestic determinants of crude oil futures prices during the COVID-19 pandemic period. We perform comparative analysis of West Texas Intermediate (WTI) and newly-launched Shanghai crude oil futures (SC) via the Quantile Autoregressive Distributed Lag (QARDL) model. The empirical results show the long- and short-run impacts of stock markets, interest rate, coronavirus panic and corn futures on WTI futures prices, while economic policy uncertainty is a driver for the long-run WTI price dynamics. However, the influence of stock market, interest rate and COVID-19 panic on SC is significant in the short term. There also exists short- and long-run positive responses of China’s crude oil futures to corn prices. Overall, the impacts of domestic price drivers are heterogeneous across market circumstances (bullish, bearish and normal) and countries. These empirical evidences provide practical implications for investors and policymakers.
An ensemble approach for circular RNA-disease association prediction using variational autoencoder and genetic algorithm
Authors: Salooja C. M. , Sanker Arjun , Deepthi K. , Jereesh A. S.
Published: July 2024

Circular RNAs (circRNAs) are endogenous non-coding RNAs with a covalently closed loop structure. They have many biological functions, mainly regulatory ones. They have been proven to modulate protein-coding genes in the human genome. CircRNAs are linked to various diseases like Alzheimer’s disease, diabetes, atherosclerosis, Parkinson’s disease and cancer. Identifying the associations between circular RNAs and diseases is essential for disease diagnosis, prevention, and treatment. The proposed model, based on the variational autoencoder and genetic algorithm circular RNA disease association (VAGA-CDA), predicts novel circRNA-disease associations. First, the experimentally verified circRNA-disease associations are augmented with the synthetic minority oversampling technique (SMOTE) and regenerated using a variational autoencoder, and feature selection is applied to these vectors by a genetic algorithm (GA). The variational autoencoder effectively extracts features from the augmented samples. The optimized feature selection of the genetic algorithm effectively carried out dimensionality reduction. The sophisticated feature vectors extracted are then given to a Random Forest classifier to predict new circRNA-disease associations. The proposed model yields an AUC value of 0.9644 and 0.9628 under 5-fold and 10-fold cross-validations, respectively. The results of the case studies indicate the robustness of the proposed model.
A Mechanics Analysis of Cumulative Damage Leading to Material Loss at Fractal Contact Interfaces Subjected to Fretting
Authors: Cen Jialiang , Komvopoulos Kyriakos
Published: July 2024

Basic understanding of the removal of material in oscillatory contacts subjected to small-amplitude oscillatory sliding, known as fretting, requires comprehensive mechanics analysis accounting for the effects of interfacial topography, surface traction, and oscillation cycles on the evolution of plasticity-induced damage. For that reason, an elastic–plastic contact mechanics analysis of an isotropic strain hardening half-space in oscillatory contact with a rigid surface exhibiting multi-scale roughness characterized by fractal geometry was performed with the finite element method. Cumulative damage was modeled with a dimensionless damage variable given by an integral equation of the equivalent plastic strain. Material degradation was tracked by a dimensionless parameter depending on the fracture energy for creating a crack of unit area, the effective stress at the initiation of material degradation, the equivalent plastic strain, and a characteristic length determined by the size of the smallest finite elements. Numerical results of the subsurface stress and plastic strain fields and the material removal rate obtained for a range of fractal parameters, normal load, and oscillation cycles illuminated the effect of the progression of plasticity-induced damage on the loss of material. Contrary to the classical wear law, the material removal (wear) rate demonstrated a nonlinear dependence on normal load, attributed to the dependence of relative slip at the contact interface on mechanical interlocking, resulting from the increase of surface conformity with the normal load and loss of material. From a fundamental perspective, this study provides a computational mechanics framework for performing parametric studies of the material removal rate in mechanical devices operating in reciprocating sliding contact mode.
Harmonic drive friction loss based on an integrated joint for collaborative robots
Authors: Chen Ya , Wu Rongqing , Wang Peng , Wang Dianjun , Gao Linlin , Liu Shujing , Song Zhongkang
Published: July 2024

To investigate the influence of the friction loss generated by the harmonic drive in the integrated robot joint transmission process on the torque control accuracy, this study analyzed the internal friction loss of the harmonic drive by establishing an integrated joint dynamics model based on multi-factor coupling. According to the nonlinear transmission characteristics of the harmonic drive, the effects of hysteresis characteristics, nonlinear friction, transmission error, and temperature on the friction loss of the harmonic drive were analyzed. With rated and peak torques of 0.4[Formula: see text]Nm and 1.44[Formula: see text]Nm, respectively, the theoretical calculations of friction loss inside the harmonic drive and simulations on the co-simulation platform to verify the results were performed. The theoretical analysis yielded friction loss rates of 8.54% and 10.41%, and the co-simulation platform yielded friction loss rates of 9.64% and 12.08%. The simulation results are consistent with the theoretical analysis, and the constructed integrated joint dynamics model is accurate. The scheme used to obtain the joint torque by measuring the deformation of the flexure wheel was found to be feasible; however, the friction loss compensation generated during the transmission process needs to be considered in practical working conditions. By analyzing the friction loss of integrated joints, this study provides the theoretical basis for the torque control of robot joints.
A comparative evaluation of turbulence models for H2/N2 combustion using the Eulerian transported PDF approach
Authors: Habib Rouan Serik , Larbi Ahmed Amine , Senouci Mohamed , Bounif Abdehamid
Published: July 2024

The Eulerian method of transported PDF is an approach that is considered to be a derivative of the delta function. Among the strengths of this method are its ability to anticipate flame extinction and ignition, as well as its capacity to kinetically control chemical components such as CO and NO[Formula: see text]. The primary objective of this study is to utilize this method to conduct a comparative evaluation of two turbulence models: the [Formula: see text]-epsilon model and the RSM model. This numerical study aims to deepen our understanding of the combustion dynamics of an H2/N2 mixture within a turbulent diffusion flame. To achieve this, the mixture is injected into a co-flow of hot air, allowing for the simulation of real conditions. The selected mixture model is the Interaction by Exchange with the Mean (IEM). For the Eulerian approach, the number of environments is set to (2,0). In this study, the model was solved using the commercial CFD software, ANSYS Fluent, and the chemical reaction mechanism employed for H2 comprises of 37 reactions involving 13 distinct species. Results are validated with the experimental data and are discussed. The integration of the PDF approach with the RSM turbulence model appears to be a valuable strategy for a better understanding of H2 flow and combustion.
Manipulation of Magnonic Activity by Electric Currents in Ferromagnetic Nanocylinders
Authors: Li Zhisheng , Yang Mingming , Fan Mingming , Zeng Xiaoyan , Yan Ming
Published: July 2024

Electric currents passing through ferromagnets can impact the magnetization dynamics via the so-called spin-transfer torque (STT) effect. In this paper, we present a theoretical study on the current influence on magnonic activity, a recently reported spin wave (SW) chiral effect in ferromagnetic nanotubes. By micromagnetic simulations, we show that an electric current can cause a significant change in the rotatory power of the SW modes propagating in a longitudinally magnetized nanotube. This result is well explained by using the Fresnel model in optics assuming a SW circular birefringence. An analytical method is developed to solve the first-order mode, yielding perfect agreements with the numerical results. Our results provide a new approach to manipulate the SW propagating properties in ferromagnetic nanocylinders.
A Meta-Model-Driven Approach to Support Digitization Evolution with Maturity Models
Authors: Bernabei Margherita , Costantino Francesco , Tronci Massimo
Published: July 2024

Digitization makes knowledge and information a centerpiece since these connect all dimensions affected by innovation, i.e., people, processes, organization, business, and technology. Maturity Models (MMs) support managers in this evolution. The paper provides a theoretical formalization of MMs to give a practical knowledge contribution to increasing the intensiveness of information in enterprises, through digitization evolution. The paper reviews the main MMs, and presents their state of the art. Then, it defines a backbone structure common to MMs to abstract and describe their features by a meta-model. The new meta-model-driven approach guides companies in the selection of MMs, and in designing a new MM, where needed. The meta-model formalizes the two-levels inputs, the process, and the output to align the company’s motivations with the MM features, resulting in the definition of an appropriate MM for organizations. A qualitative exploratory case study shows the approach and its results, providing guidelines for future actions.
A computational study on buckling strength of pressurised submarine pressure hull structures under combined static load and asymmetric impact load
Authors: Minzhan Huang , Zhentao Jiang , Yuxiang Peng , Pengnan Sun , Niannian Liu
Published: July 2024

Through the reconstructed kernel particle method (RKPM), the dynamic buckling characteristics of submarine pressure hull under hydrostatic pressure and impact load is investigated in this study. First, a large deformation buckling calculation model for stiffened shell structures was established using RKPM and elastic–plastic constitutive models. To study the influence of load asymmetry on the buckling strength of the structure and provide fundamental technical support for submarine structural design, the dynamic buckling phenomenon of the structure was studied under three conditions: hydrostatic pressure acting alone, hydrostatic pressure and impact load acting simultaneously, and hydrostatic pressure and uniformly distributed impact load acting simultaneously. The starting time of buckling was used as the criterion for determining the critical load of dynamic buckling. The results indicate that under the combined action of static and dynamic loads, asymmetric dynamic loads can seriously affect the buckling strength of the structure.
Topological characterisation of three classes of complex networks and their graphical representation and analysis
Authors: Ahmed Wakeel , Zaman Shahid , Ashraf Sana
Published: July 2024

Mathematical Chemistry is concerned with the use of mathematics to solve problems in Chemistry. In Chemistry, the molecules are frequently shown as graphs with vertices denoting atoms and edges denoting bonds, respectively. Atom valences and bond multiplicities are represented by vertex degrees and edge multiplicities, respectively. The vertices in a graph are said to be close by if an edge connects them. Alkanes are a class of compounds whose physical characteristics are modelled using the chemical graph theory. The melting and boiling points of the molecules are modelled using topological indices based on the graphical structure of the alkanes. A mesh network is a local area network, in which the infrastructure nodes (i.e., bridges, switches and other infrastructure devices) connect directly, dynamically and non-hierarchically to as many other nodes as possible and cooperate with one another to efficiently route data. In this paper, the distinct degrees of triangular mesh network, enhanced mesh network, rhenium tri-oxide lattice network and star of silicate network are list with edge partitions technique. We determine the first and second Zagreb index, the modified second Zagreb index, the symmetric division index, the harmonic index and the inverse sum index. We characterise detailed proofs of these indices for each triangular network. Furthermore, their graphical representation and comparison between the certain topological indices is presented in Sec. 6. These indices are highly accurate in the study of QSPRs and QSARs because they have strong correlation with the acentric factor and entropy.
Molecular Docking, Quantum Mechanics and Molecular Dynamics Simulation of Anti-CAD Drugs Against High-Risk Xanthine Dehydrogenase Variants Associated with Oxidative Stress Pathways
Authors: Janakiraman V. , Sudhan M. , Ahmad Sheikh F. , Attia Sabry M. , Emran Talha Bin , Ahmed Shiek S. S. J.
Published: July 2024

Xanthine dehydrogenase (XDH) contributes significantly to generating reactive oxygen species in coronary artery disease (CAD). XDH has been proposed as a therapeutic target, but its genetic variants could affect protein structure and drug response. We aimed to assess protein structure modification occur due to genetic variants and to screen 215 CAD drugs for their utility in personalized CAD treatment against the XDH variants. A series of computational methods were implemented to identify pathogenic variants that cause XDH structure instability localized at the con served regions contributing to functional significance. Then, the XDH structures with the pathogenic variants were modeled using two different approaches to select the best models for docking with the CAD drugs. Finally, the stability of the docked complexes and their ability to transfer electrons were evaluated using molecular dynamics (MD) simulations and quantum mechanics/molecular mechanics (QM/MM) calculation. Among 751 variants examined; R149C and Q919R showed high pathogenicity, localized in conserved regions could alter protein structure and function. Further, docking of CAD drugs against XDH (native, R149C and Q919R) showed vericiguat with higher affinity, ranging from −7.95 kcal/mol to −10.41 kcal/mol, than the well-known XDH inhibitor (febuxostat, −5.73 kcal/mol to −8.35 kcal/mol). This indicates that vericiguat will be effective in CAD treatment, regardless of the XDH variants. Additionally, MD simulation and QM/MM confirmed vericiguat stability and electron transfer ability to form hydrogen bonds with the XDH protein. In conclusion, vericiguat will be beneficial for the personalized treatment of CAD by inhibiting XDH variants. Additional clinical studies are necessary to confirm our findings.
Lamprophyres, gold and orogenies: a mineral systems perspective
Authors: Wyman Derek
Published: July 2024

The common spatial and temporal association of calk alkaline lamprophyres with orogenic gold deposits has been recognized for more than a century, although interpretations regarding the significance of this association have varied greatly. A persistent lack of consensus on Archean geodynamics and the deposits themselves presented a challenge to the use of a Mineral Systems approach, given that models should strive to encompass a source to sink understanding of deposit generation. Lamprophyres helped to resolve these issues because the compositions of the most primitive examples establish firm constraints on deep crustal and upper mantle regimes at the time of deposit formation, despite not being directly related to mineralization. Following the initial contribution of lamprophyres toward a coherent model of mineralization, numerous workers provided the important observations and refinements that have resulted in a robust Mineral Systems model for the deposit type. The discovery of diamonds in gold-associated lamprophyres, and circumstantial evidence that this association has been long-lived and widespread, presents opportunities to further refine orogenic gold models.
Harnessing Representative Spatial-Temporal Information for Video Question Answering
Authors: Wang Yuanyuan , Liu Meng , Song Xuemeng , Nie Liqiang
Published: July 2024

Video question answering, aiming to answer a natural language question related to the given video, has become prevalent in the past few years. Although remarkable improvements have been obtained, it is still exposed to the challenge of insufficient comprehension of video content. To this end, we propose a spatial-temporal representative visual exploitation network for video question answering, which enhances the understanding of the video by merely summarizing representative visual information. In order to explore representative object information, we advance adaptive attention based on uncertainty estimation. At the same time, to capture representative frame-level and clip-level visual information, we structure a much more compact set of representations iteratively in an expectation-maximization manner to deprecate noisy information. Both the quantitative and qualitative results on NExT-QA, TGIF-QA, MSRVTT-QA, and MSVD-QA datasets demonstrate the superiority of our model over several state-of-the-art approaches.
Dynamically Balancing Load with Overload Control for Microservices
Authors: Bhattacharya Ratnadeep , Gao Yuan , Wood Timothy
Published: July 2024

The microservices architecture simplifies application development by breaking monolithic applications into manageable microservices. However, this distributed microservice “service mesh” leads to new challenges due to the more complex application topology. Particularly, each service component scales up and down independently creating load imbalance problems on shared backend services accessed by multiple components. Traditional load balancing algorithms do not port over well to a distributed microservice architecture where load balancers are deployed client-side. In this article, we propose a self-managing load balancing system, BLOC, which provides consistent response times to users without using a centralized metadata store or explicit messaging between nodes. BLOC uses overload control approaches to provide feedback to the load balancers. We show that this performs significantly better in solving the incast problem in microservice architectures. A critical component of BLOC is the dynamic capacity estimation algorithm. We show that a well-tuned capacity estimate can outperform even join-the-shortest-queue, a nearly optimal algorithm, while a reasonable dynamic estimate still outperforms Least Connection, a distributed implementation of join-the-shortest-queue. Evaluating this framework, we found that BLOC improves the response time distribution range, between the 10th and 90th percentiles, by 2 –4 times and the tail, 99th percentile, latency by 2 times.
Systemic hemodynamics and pediatric lung disease: mechanistic links and therapeutic relevance
Authors: Sehgal Arvind , South Andrew M. , Menahem Samuel
Published: July 2024

Chronic lung disease, also known as bronchopulmonary dysplasia, affects thousands of infants worldwide each year. The impact on resources is second only to bronchial asthma, with lung function affected well into adolescence. Diagnostic and therapeutic constructs have almost exclusively focused on pulmonary architecture (alveoli/airways) and pulmonary hypertension. Information on systemic hemodynamics indicates major artery thickness/stiffness, elevated systemic afterload, and/or primary left ventricular dysfunction may play a part in a subset of infants with severe neonatal-pediatric lung disease. Understanding the underlying principles with attendant effectors would aid in identifying the pathophysiological course where systemic afterload reduction with angiotensin-converting enzyme inhibitors could become the preferred treatment strategy over conventional pulmonary artery vasodilatation.
Effect of Bidirectional Ground Motion on the Response of Double Concave Friction Pendulum Systems
Authors: Li Jiaxi , Tan Ping , Yang Kui , Zheng Haowen , Yamazaki Shinsuke , Kishiki Shoichi
Published: July 2024

Recent destructions of structures due to insufficient isolator deformation capacity have led to demands for greater seismic redundancy in seismic isolation design. For a friction pendulum system (FPS), the effect of bidirectional behavior of earthquakes on the maximum response and its effect on friction heating, temperature, and in turn on the maximum response can be significant. However, the extent of these effects under different FPS design parameters and different types of ground motions (GMs) is still not clear. In this study, an analytical model of double concave FPS considering the coupling effect of friction heating and bidirectional behavior was proposed and validated by bidirectional earthquake response orbits, which reflect the characteristics of both GMs and FPSs. Then, the effects of bidirectional GM and corresponding bidirectional temperature change on the response were investigated under different types of strong GMs. Finally, a performance‐based design method with a bidirectional‐effect‐compensation mechanism was proposed. For double concave friction pendulum bearings with PTFE‐related layers, it was found that the bidirectional behavior of earthquakes will amplify the maximum isolator displacement by an average of 110–210% (60 MPa) and the maximum superstructure acceleration by an average of 100–140% (60 MPa) under strong GMs (PGV‐C1 > 0.2 m/s) and optimum design parameters. The amplification ratio is not only influenced by GM characteristics but also highly related to the design parameters and friction‐heating effect of DCFPS.
Assessment of Anaesthesia Teams’ Non‐Technical Skills in Clinical Practice before and after Simulation‐Based Team Training: A Quasiexperimental Study
Authors: Finstad Anne Strand , Bjørshol Conrad Arnfinn , Aase Ingunn , Røislien Jo , Ballangrud Randi
Published: July 2024

Background. In situ simulation‐based team training of non‐technical skills is considered an important initiative for preventing adverse events caused by poor teamwork among healthcare personnel. This study aimed to assess the non‐technical skills of anaesthesia personnel before and after in situ simulation‐based team training in a clinical setting. Methods. The study was conducted from October 2020 to June 2021 using a quasiexperimental before and after design based on video‐recorded observations and ratings of anaesthesia teams’ non‐technical skills during anaesthesia induction in the operating room before and shortly after in situ simulation‐based team training. Anaesthesia personnel were divided into 20 teams and video recorded during anaesthesia induction. The Anaesthetists’ Non‐technical Skills (ANTS) system was used to score the teams’ non‐technical skills. A paired‐sample t‐test was used to assess the impact of the intervention on the anaesthesia teams’ scores on the various ANTS categories. Interrater agreement between the two ANTS raters was assessed using weighted kappa. Results. At the category level, the overall scores had a statistically significant increase in performance after simulation‐based team training (3.48 vs. 3.71; p < 0.001). Furthermore, scores of five of the 15 elements were significantly different. Interrater agreement revealed moderate agreement between the two raters (weighted kappa = 0.51, p value <0.001). Conclusion. The anaesthesia teams’ increased non‐technical skills after simulation‐based team training may indicate the transfer of knowledge from training to clinical practice. The moderate agreement between the raters could be attributed to the subjective nature of the evaluation procedure. The ANTS was originally used as an individual assessment tool; however, this study has demonstrated its potential as a team assessment tool.
Nurses’ Readiness for Catastrophe Management and Its Relation to Their Organizational Commitment: Recommendations for Education
Authors: Ali Aziza Z. , Alkubati Sameer A. , Al-Sadi Ahmad K. , Elsayed Wessam A. , Nageeb Shaimaa M. , Saber Nahed M. , Alenizi Sara F. , Alanazi Seham S. , Alkuwaisi Mohannad J. , Hamed Laila A.
Published: July 2024

Background. Catastrophes are challenging events for nations and health systems that require healthcare providers, especially nurses, to be prepared to respond effectively. Although nurses play a critical role in managing catastrophes and postcatastrophic situations, their preparedness is often inadequate and affected by their organizational commitment. Therefore, this study assessed nurses’ preparedness for catastrophe management and its relationship with their organizational commitment. Methods. A cross‐sectional correlational, descriptive design involving 286 conveniently sampled nurses was conducted in four public hospitals in Hail city. Data were collected using a questionnaire that compiled two tools: the Disaster Preparedness Evaluation Tool to assess nurses’ preparedness for catastrophe management and the Organizational Commitment Scale to assess their attachment to their hospitals. Correlations between mean scores of nurses’ knowledge, skills, and preparedness for postcatastrophe management and organizational commitment were tested using Spearman’s correlation, with a significance level of <0.05. Results. Most nurses had low levels of knowledge (79.7%), skills (78.7%), and preparedness for postcatastrophe management (78.7% each). Meanwhile, 57.3% of nurses had low levels of affective commitment to their hospitals, compared to 78.7% for continuance and normative commitments. Statistically significant positive, moderate correlations were found between nurses’ knowledge and skills in managing catastrophes (r = 0.512; p < 0.01) and knowledge and preparedness for postcatastrophe management (r = 0.492; p < 0.01), as well as nurses’ skills and preparedness for postcatastrophe management (r = 0.533; p < 0.01). However, the nurses’ level of organizational commitment was not significantly correlated with their knowledge, skills, or preparedness for postcatastrophe management. Conclusion. Nurses in Hail city are not adequately prepared to respond to and manage catastrophes and postcatastrophic situations, and they have low organizational commitments to their hospitals. Therefore, nursing education should integrate catastrophe management into the curricula, and hospital administrators should prioritize a supportive work environment that strengthens organizational commitment and provides ongoing education and regular training to improve nurses’ preparedness for catastrophe management.
A Novel Long Short‐Term Memory Learning Strategy for Object Tracking
Authors: Wang Qian , Yang Jian , Song Hong
Published: July 2024

In this paper, a novel integrated long short‐term memory (LSTM) network and dynamic update model are proposed for long‐term object tracking in video images. The LSTM network tracking method is introduced to improve the effect of tracking failure caused by target occlusion. Stable tracking of the target is achieved using the LSTM method to predict the motion trajectory of the target when it is occluded and dynamically updating the tracking template. First, in target tracking, global average peak‐to‐correlation energy (GAPCE) is used to determine whether the tracking target is blocked or temporarily disappearing such that the follow‐up response tracking strategy can be adjusted accordingly. Second, the data with target motion characteristics are utilized to train the designed LSTM model to obtain an offline model, which effectively predicts the motion trajectory during the period when the target is occluded or has disappeared. Therefore, it can be captured again when the target reappears. Finally, in the dynamic template adjustment stage, the historical information of the target movement is combined, and the corresponding value of the current target is compared with the historical response value to realize the dynamic adjustment of the target tracking template. Compared with the current mainstream efficient convolution operators, namely, the E.T.Track, ToMP, KeepTrack, and RTS algorithms, on the OTB100 and LaSOT datasets, the proposed algorithm increases the distance precision by 9.9% when the distance threshold is 5 pixels, increases the overlap success rate by 0.94% when the overlap threshold is 0.75, and decreases the center location error by 18.9%. The proposed method has higher tracking accuracy and robustness and is more suitable for long‐term tracking of targets in actual scenarios than are the main approaches.
Inclined Magnetic Field on Mixed Convection Darcy–Forchheimer Maxwell Nanofluid Flow Over a Permeable Stretching Sheet With Variable Thermal Conductivity: The Numerical Approach
Authors: Adem Gossaye Aliy , Chanie Adamu Gizachew
Published: July 2024

The behavior of a Maxwell nanofluid in mixed convection Darcy–Forchheimer inclined MHD flow across a stretched sheet is investigated in this research study. In order to analyze heat and mass transfer, the inquiry takes into account a number of variables, including the magnetic field, variable thermal conductivity, activation energy, suction/injection, and nonlinear thermal radiation. The controlling nonlinear PDEs with BCs are converted via similarity transformation into nonlinear ODEs in order to solve the ensuing nonlinear ODEs. These ODEs are then solved using the shooting method and a fourth‐order Runge‐Kutta methodology. The study explores how fluid flow velocity is affected by magnetic field inclination and suction/injection effects. This is attributed to the strengthening of the magnetic field with an increase in the inclination angle α. Additionally, the imposed magnetic field generates an opposing force, known as the Lorentz force, which contributes to a reduction in the velocity curve. Furthermore, various parameters affect the profiles of concentration, temperature, velocity, and Nusselt number. A number of parameters are looked at, such as the response rate constant, mixed convection, buoyancy ratio, suction/injection, Brownian motion, Lewis number, and thermophoresis. Interestingly, the results show that activation energy and mixed convection parameters, respectively, have an increasing effect on concentration and velocity curves.
Perspectives on Drug Development for the Treatment of Chronic Myeloid Leukemia in Pregnant Patients and Patients Who Are Breastfeeding
Authors: Cortes Jorge E. , Abruzzese Elisabetta , Cardonick Elyce H. , Hernández-Díaz Sonia , Gutierrez Jamie , Sardegna Mary S. , Torres-Chavez Erica , Dinatale Miriam , Lerro Catherine C. , Gehrke Brenda J. , Shord Stacy S. , De Claro R. Angelo , Theoret Marc R. , DeMaria Peter J. , Norsworthy Kelly J.
Published: July 2024

Tyrosine kinase inhibitors (TKI) have improved the outcome and life expectancy of patients with chronic myeloid leukemia (CML). Patients are diagnosed with CML at younger ages, and patients treated for CML may become pregnant or choose to breastfeed. The information available to date on the safety of TKIs during pregnancy and lactation and the optimal management of these patients is largely anecdotal, based on personal or small-group experience, and heterogeneous. A panel of interested parties was convened by U.S. Food and Drug Administration to analyze the current data and discuss possible solutions. Possible solutions include prospective data collection, in clinical trials and in routine clinical practice, a more uniform and specific data collection, and greater coordination among involved entities. As patients with cancer are living longer, frequently receiving therapies for extended periods of time (or for life), data on appropriate management of patients through different reproductive phases of life are needed. It is thus time to change our approach for how to study treatment of cancer (including CML) during pregnancy or breastfeeding to develop evidence-based guidelines for safe and effective patient care.
Supplementary Figure S2 from The Novel ATR Inhibitor Tuvusertib (M1774) Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs
Authors: Jo Ukhyun , Arakawa Yasuhiro , Zimmermann Astrid , Taniyama Daiki , Mizunuma Makito , Jenkins Lisa M. , Maity Tapan K. , Kumar Suresh , Zenke Frank T. , Takebe Naoko , Pommier Yves
Published: July 2024

This figure shows a Volcano plot of abundance ratio between M1774 and control.
Supplementary Data set 1 from The Novel ATR Inhibitor Tuvusertib (M1774) Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs
Authors: Jo Ukhyun , Arakawa Yasuhiro , Zimmermann Astrid , Taniyama Daiki , Mizunuma Makito , Jenkins Lisa M. , Maity Tapan K. , Kumar Suresh , Zenke Frank T. , Takebe Naoko , Pommier Yves
Published: July 2024

Data set of Tandem mass tag (TMT)-Liquid Chromatography Mass Spectrometry (LC-MS)
Figure S8 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer
Authors: Uo Takuma , Ojo Kayode K. , Sprenger Cynthia C.T. , Epilepsia Kathryn S. , Perera B. Gayani K. , Damodarasamy Mamatha , Sun Shihua , Kim Soojin , Hogan Hannah H. , Hulverson Matthew A. , Choi Ryan , Whitman Grant R. , Barrett Lynn K. , Michaels Samantha A. , Xu Linda H. , Sun Vicky L. , Arnold Samuel L.M. , Pang Haley J. , Nguyen Matthew M. , Vigil Anna-Lena B.G. , Kamat Varun , Sullivan Lucas B. , Sweet Ian R. , Vidadala Ram , Maly Dustin J. , Van Voorhis Wesley C. , Plymate Stephen R.
Published: July 2024

Figure S8 shows effects of BKIDC-1553 and 1553-N-Me on intracellular ATP levels in LNCaP, PC3, and DU145 cells.
Figure S5 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer
Authors: Uo Takuma , Ojo Kayode K. , Sprenger Cynthia C.T. , Epilepsia Kathryn S. , Perera B. Gayani K. , Damodarasamy Mamatha , Sun Shihua , Kim Soojin , Hogan Hannah H. , Hulverson Matthew A. , Choi Ryan , Whitman Grant R. , Barrett Lynn K. , Michaels Samantha A. , Xu Linda H. , Sun Vicky L. , Arnold Samuel L.M. , Pang Haley J. , Nguyen Matthew M. , Vigil Anna-Lena B.G. , Kamat Varun , Sullivan Lucas B. , Sweet Ian R. , Vidadala Ram , Maly Dustin J. , Van Voorhis Wesley C. , Plymate Stephen R.
Published: July 2024

Figure S5 shows cell cycle profiles and histograms of DAPI-stained cells with BKIDCs.
Figure S2 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer
Authors: Uo Takuma , Ojo Kayode K. , Sprenger Cynthia C.T. , Epilepsia Kathryn S. , Perera B. Gayani K. , Damodarasamy Mamatha , Sun Shihua , Kim Soojin , Hogan Hannah H. , Hulverson Matthew A. , Choi Ryan , Whitman Grant R. , Barrett Lynn K. , Michaels Samantha A. , Xu Linda H. , Sun Vicky L. , Arnold Samuel L.M. , Pang Haley J. , Nguyen Matthew M. , Vigil Anna-Lena B.G. , Kamat Varun , Sullivan Lucas B. , Sweet Ian R. , Vidadala Ram , Maly Dustin J. , Van Voorhis Wesley C. , Plymate Stephen R.
Published: July 2024

Figure S2 shows crystal violet-based cell proliferation assay.
Figure S14 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer
Authors: Uo Takuma , Ojo Kayode K. , Sprenger Cynthia C.T. , Epilepsia Kathryn S. , Perera B. Gayani K. , Damodarasamy Mamatha , Sun Shihua , Kim Soojin , Hogan Hannah H. , Hulverson Matthew A. , Choi Ryan , Whitman Grant R. , Barrett Lynn K. , Michaels Samantha A. , Xu Linda H. , Sun Vicky L. , Arnold Samuel L.M. , Pang Haley J. , Nguyen Matthew M. , Vigil Anna-Lena B.G. , Kamat Varun , Sullivan Lucas B. , Sweet Ian R. , Vidadala Ram , Maly Dustin J. , Van Voorhis Wesley C. , Plymate Stephen R.
Published: July 2024

Figure S14 shows expression of HK2 in prostate cancer cell lines.
Figure S4 from Zinc-alpha-2-glycoprotein Secreted by Triple-Negative Breast Cancer Promotes Peritumoral Fibrosis
Authors: Verma Surbhi , Giagnocavo Stephanie D. , Curtin Meghan C. , Arumugam Menusha , Osburn-Staker Sandra M. , Wang Guoying , Atkinson Aaron , Nix David A. , Lum David H. , Cox James E. , Hilgendorf Keren I.
Published: July 2024

Supplemental Figure and Figure Legend 4
The Characteristic of toddler’s reproductive health in Posyandu Matahari, Blimbing, Malang
Authors: Seputra Kurnia Penta , Daryanto Besut , Prasetyo Zen Ary , Meiyanto Johannes Dwi
Published: July 2024

Objectives. The screening of reproductive health plays an essential role in early detection of reproductive health disorder. There was a study which suggested that there was at least one congenital disorder every 100 live births. Congenital reproductive disorders are mostly found in type of hypospadias, enlarged clitoris, micropenis, fusion of labia majora, and genital ambiguity. Data collected in Saiful Anwar General Hospital revealed that during the period of 2012-2017 there were 109 hypospadias cases, 64 undescended testicle cases, and 80 cases of testicular torsion. However, for the Disorders of Sex Development cases, there were 12 cases from the period of 2015-2017, with the mean age was school age (8-14 years old). Unfortunately, there was no data of congenital reproductive disorder in toddlers, thus we conducted screening of toddlers reproductive health in Posyandu Matahari which located in Gedung Serbaguna Rw. 14, Kelurahan Bunulrejo, Kelurahan Jodipan, Kecamatan Blimbing, Malang in order to find out the number of incidence of toddlers congenital reproductive disorder and held the early detection.Methods. This is observational descriptive study. Screening was held in Posyandu Matahari which is located in Gedung Serbaguna Rw. 14, Kelurahan Bunulrejo, Kelurahan Jodipan, Kecamatan Blimbing, Malang, on October 27, 2018. It used a method of physical examination (age, weight, height, external genital examination), and if it was found suspicious of disease or disorder of toddler congenital reproductive health, thus it would be given referral to appropriate health care.Results. This screening event involved 46 toddlers (1-5 years old). From 46 toddlers, there were 14 toddlers (30.43%), 10 toddlers suffered from Phimosis (21.74%), 1 toddler with Hydrocele (2.17%), dan 3 toddlers suffered from Undescended Testis (UDT) (6.52), who were referred to urology clinic in Saiful Anwar General Hospital to undergo further examination and treatment.Conclusions. The incidence of toddlers reproductive disorder of this event was 30,43%, showing that this age group (1-5 years old) had a significant amount of congenital reproductive disorder and screening played an important role for early detection and improving parental knowledge to prevent the delay of treatment for reproductive disorder.
Multiple Epidermoid Cyst on Frenulum and Ventral Preputium of the Penis: A Case Report
Authors: Handoyo Dimas Bintoro Kresna Yustisia , Junior I Wayan Jorden , Duarsa Gede Wirya Kusuma , Rosidah Aris
Published: July 2024

Penile epidermoid cyst are uncommon cases and more rare with a multiple cyst on the penile. We presented a twelve-year-old male patient with a case of 1 month growing, mobilized, non-tender frenulum and ventral preputium of the penis mass. Circumcision and total excision was performed under local anesthesia. Pathological examination was revealed as epidermoid cyst. Observation was carried out on the patient, first control the patient has a recurrent nodule grew only on the frenulum and aspiration was carried out and administration of antibiotics and corticosteroid was given, second control patient came to complete recovery.
Probability of Cardiovascular Death in Patients with Prostate Cancer Receiving Androgen Deprivation Therapy (ADT): A Comprehensive Analysis
Authors: Rofifa Amira Fithri , Prawira Adhananta Zhafran , Rifqiawan Muhammad Zulfan , Permatasari Dinda Eka , Daryanto Besut , Seputra Kurnia Penta
Published: July 2024

Background. ADT, or androgen deprivation therapy, is one of the most effective treatments for prostate cancer. It works by reducing testosterone levels to levels that would cause castration either medication or surgery. ADT has been associated with a significant improvement in cancer-related survival; however, reports of cardiovascular (CV) problems connected to ADT treatment are on the rise.Objectives. To demonstrate the risk of cardiovascular death in patients with prostate cancer treated with ADT.Methods. This study demonstrated compliance with the parameters set forth by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020. With this search strategy, articles published between 2014 and 2024 were taken into consideration. This was accomplished by utilizing a number of distinct online reference sites, including Pubmed, SagePub, and Google Scholar. Review articles, previously published works, and partially completed works were all selected not to be considered.Results. We found 221 papers in the PubMed database, 47 articles on SagePub, and 9050 items on Google Scholar as a result of our search. 7287 records were removed before screening, hence 2030 articles were received for review. Following a record-exclusion screening, we assembled ten publications in total. Five studies that fulfilled the requirements were included.Conclusion. ADT is frequently a crucial component of the treatment of prostate cancer; patients should also receive counselling regarding their elevated risk of cardiovascular events and should think about taking preventative measures to lower that risk.
Detetive climático : caderno do-da educador-educadora - vol. 2
Authors: Cseh Amanda , Cavaco Isabela Carmo , Gomes Aline da Conceição ,   Universidade de São Paulo. Instituto de Energia e Ambiente,   Universidade de São Paulo. Escola de Artes, Ciências e Humanidades
Published: July 2024

A obra "Detetive climático : caderno do-da educador-educadora - vol. 2" integra a Série NOSS Educação para Justiça Climática, um resultado do “Projeto de Pesquisa Participativa em Ação: Educação para Justiça Climática no Vale do Ribeira” desenvolvido pelo NOSS EACH USP, com fomento internacional Climate-U, sob coordenação do INCLINE USP. O objetivo central é contribuir para que a escola se transforme em um epicentro estratégico na promoção da justiça climática, criando subsídios e inspirando educadores e educadoras para que sejam difusores de conhecimento para ação climática e, consequentemente, para que os estudantes se tornem agentes centrais para mudança de suas comunidades. A estratégia metodológica do Detetive Climático é baseada na educação dialógica de Paulo Freire, aprendizagem significativa e a Ciência Cidadã. Inclui atividades participativas e reflexão individual.
Where did that dental bur go? Patient Safety Lessons from a Dental Teaching Hospital
Authors: Marchan Shivaughn
Published: July 2024

Introduction: Ingested or aspirated dental burs have been reported in the literature. These events are akin to medical errors that can potentially cause patient morbidity or mortality and must be examined in the larger context of maintaining patient safety in dental settings. Case report: This work presents a case of an ingested bur and a near-miss event of a bur detached from a high-speed dental handpiece. Both cases occurred during the management of patients by students in a dental school setting. Conclusion: These cases are presented through the lens of patient safety. Conclusions are made on how organizational policies and curricula change can prevent such errors in the dental clinical training environment and mitigate patient morbidity or mortality.
Outcomes Among Mexican American and Non-Hispanic White Informal Stroke Caregivers
Authors: Lisabeth Lynda D. , Gallo Linda C. , Prvu-Bettger Janet , Kwicklis Madeline , Almendarez Elizabeth M. , Morgenstern Lewis B.
Published: July 2024

BACKGROUND:

Informal home care is prevalent among Mexican American stroke survivors, but data on the impact on caregivers are not available. The aim was to assess ethnic differences in informal stroke caregiving and caregiver outcomes at 90 days poststroke.

METHODS:

Informal caregivers were recruited from the population-based Brain Attack Surveillance in Corpus Christi Project (2019–2023), conducted in a bi-ethnic community in Texas. Caregivers of community-dwelling stroke survivors who were not cognitively impaired and not employed by a formal caregiving agency were interviewed. Interviews included sociodemographics, dyad characteristics, Modified Caregiver Strain Index (range 0–26, higher more positive), Positive Aspects of Caregiving scale (range, 5–45, higher more), Patient Health Questionnaire-8 (range, 0–30, higher worse), and PROMIS (Patient-Reported Outcomes Measurement Information System)-10 physical (range, 16.2–67.7, higher better) and mental health (range, 21.2–67.6, higher better) summary scores. Stroke survivor data was from interviews and medical records. Propensity score methods were used to balance caregiver and patient factors among Mexican American and Non-Hispanic White caregivers by fitting a model with ethnicity of caregiver as the outcome and predictors being caregiver sociodemographics, patient-caregiver dyad characteristics, and patient sociodemographics and functional disability. Propensity scores were included as a covariate in regression models, considering the association between ethnicity and outcomes.

RESULTS:

Mexican American caregivers were younger, more likely female, and more likely a child of the stroke survivor than Non-Hispanic White caregivers. Mexican American caregiver ethnicity was associated with less caregiver strain (β, −1.87 [95% CI, −3.51 to −0.22]) and depressive symptoms (β, −2.02 [95% CI, −3.41 to −0.64]) and more favorable mental health (β, 4.90 [95% CI, 2.49–7.31]) and positive aspects of caregiving (β, 3.29 [95% CI, 1.35–5.23]) but not associated with physical health.

CONCLUSIONS:

Understanding the mechanisms behind more favorable caregiver outcomes in Mexican American people may aid in the design of culturally sensitive interventions to improve both caregiver and stroke survivor outcomes, potentially across all race and ethnic groups.