bluuebunny/crossref_metadata_2025 huggingface dataset:
Histopathological Study of Appendectomy Specimens in a Rural Tertiary Care Hospital in Bangladesh
Authors: Rahman Shamim , Karim Syeda Noorjahan , Al Tanzim S M Maruf , Kabir Evana , Sen Sampurna , Bristy Fariha Rahman , Poly Khaleda Rahman
Published: April 2023

Background: Appendicitis is one of the most common causes of the acute abdomen that demands emergency surgical intervention. It is a clinical condition that is frequently encountered as a diagnostic challenge. Sometimes grossly normal-appearing appendix, removed from patients with suspected acute appendicitis, on histopathological examination may reveal a more serious underlying pathology. Hence, histopathological studies form the gold standard for the diagnosis of appendicitis.
Aim: To study the histopathological patterns of appendicitis in patients who underwent appendectomy.
Methods: This study was carried out in the department of Pathology, Jahurul Islam Medical College, Bajitpur, Kishoreganj from January 2020 to December 2020. All the appendectomy specimens were received in 10% formalin as fixative. Sections obtained were studied to determine various histopathological patterns in appendectomy specimens.
Results: A total of 252 specimens were undertaken for histopathological examination. There were 154 (61.1%) males and 98 (38.1%) females with male to female ratio of 1.6:1.  The most common lesion observed was acute appendicitis (51.98%) followed by recurrent appendicitis (28.17%), acute suppurative appendicitis (07.15%), gangrenous appendicitis (06.36%), eosinophilic appendicitis (02.38%), follicular lymphoid hyperplasia (02.38%), mucinous adenoma (0.40%) and mucinous adenocarcinoma (02.38%). 
Conclusion: Most of the cases in this study were diagnosed with the usual features of appendicitis, though a few of them were incidental diagnoses that were missed clinically. These important incidental diagnoses undisputedly support the notion that every appendectomy specimen must be sent routinely for histopathological examination.
Mediscope 2023;10(1): 17-21
Effectiveness of Vaccines and Barriers Against Effective Cold Chain Systems
Authors: Osadolor Owens O , Osadolor Obehi O , Osadolor Aisosa J , Ekpeti Azuka P
Published: April 2023

Vaccination is often considered a cost-effective strategy for the prevention and control of most infectious diseases or vaccine-preventable diseases. Poverty, ignorance, cultural belief and practices, locality of residence, level of awareness on vaccine safety and lack of access to health care facilities are among the obstacles to vaccination leading to low vaccine coverage. Low vaccine coverage among young children across remote and rural areas, slums and riverine areas is not a reflection of the health and social-related Sustainable Development Goals. Poor handling of vaccines has been identified as one of the reasons for the reduction in vaccine effectiveness at the time of administration. Cold chain is the system of transporting, storing and distributing vaccines in a viable state at the recommended temperature from the point of manufacture to the point of use. Some factors contributing to the weakness of the cold chain are delays during transportation, quality of refrigerators, method of storage, period of storage at the health facility, improper use of refrigerators, equipment breakage, lack of trained personnel capable of managing the cold chain, unreliable power sources and limited resources (material, financial, and human).
Mediscope 2023;10(1): 38-41
Role of Root Canal Sealer on the Post Operative Pain: a Randomized Control Trial
Authors: Mahmud Kazi Hossain , Talukder Mohammad Fida Hasan , Rahman Mirza Md Arifur , Ali Hasan , Hossain Farjana
Published: April 2023

Background: Recent innovations in pulp treatment and root canal sealers include bioceramic. It is proven how bioceramics affect root restoration, radiculer perforation, and vital pulp therapy. Therefore, it is anticipated that using bioceramics as a root canal sealer in traditional root canal therapy for non-vital teeth will have positive results.
Methods:  In this investigation, 60 nonvital teeth with periapical lesions were included. These teeth were separated into two groups of 30 teeth each and treated as follows: Group A: Bioceramics (Endocequence BCTM) sealer was used to obturate these teeth. Group B was obturated using a sealer based on Zinc Oxide Eugenol (Tubli-sealTM). Participants were contacted after 3, 6, and 12 months. The clinical outcome was assessed by assessing pain by VAS, tenderness on percussion, and using the Chi-square test and unpaired student t-test for testing differences between the two groups, with a p value of 0.05 regarded as statistically significant.
Results: It was discovered that at 6 and 12 months of observation, 100% of teeth treated with Bioceramics' root canal sealer and 93.3% of teeth treated with Zinc Oxide Eugenol did not exhibit any discomfort or soreness to percussion. The differences between the groups treated with Zinc Oxide Eugenol and Bioceramics root canal sealer were not statistically significant (p > 0.05).
Conclusion:It may be determined that both bioceramic-based sealers (Endosequence BC) and zinc oxide-eugenol-based sealers (Tubli-seal TM) are efficient in reducing post-operative discomfort after endodontic therapy. As a result, sealer has no effect on post-operative pain relief.
Update Dent. Coll. j: 2023; 13(1): 31-34
Các nhân tố ảnh hưởng đến ý định lựa chọn nhà hàng của thực khách: Nghiên cứu ứng dụng mô hình PLS-SEM
Authors: Nguyễn Thị Loan , Mai Anh Vũ , Hà Đình Hùng
Published: April 2023

Nghiên cứu tập trung phân tích nhân tố ảnh hưởng đến ý định lựa chọn nhà hàng của thực khách trên cơ sở kế thừa và phát triển các thang đo nghiên cứu phù hợp với tình hình và bối cảnh hiện tại. Mẫu nghiên cứu gồm 183 phản hồi của thực khách đã trải nghiệm nhà hàng trên địa bàn thành phố Thanh Hoá đủ điều kiện đưa vào phân tích bằng phần mềm thống kê Smart PLS 4.0 và mô hình cấu trúc PLS - SEM. Kết quả cho thấy, chất lượng đồ ăn, chất lượng dịch vụ, giá cả và vị trí nhà hàng là các nhân tố có mức độ tác động mạnh nhất đến ý định lựa chọn nhà hàng. Trên cơ sở kết quả nghiên cứu, tác giả khuyến nghị một số giải pháp giúp các nhà hàng có định hướng phù hợp đáp ứng tốt hơn nhu cầu khách hàng và phát triển hoạt động kinh doanh trong thời gian tới.
First record of Microcerotermes lahorensis Akhtar (Blattodea, Isoptera, Termitidae) from India
Authors: Joseph Edwin , Albright B. , Francis Amala Anna , Jayan Namitha , Mathew Jobin
Published: April 2023

Reports a subterranean termite species Microcerotermes lahorensis Akhtar from Kerala, India, for the first time. The species was only reported from the type locality Lahore, Pakistan, and was endemic to the country. This new record thus changes the endemic status of the species and reaffirms the cosmotropical nature of the genus Microcerotermes.
VIOLAÇÃO DE PRINCÍPIOS E IMPROBIDADE ADMINISTRATIVA: UMA NECESSÁRIA INTERPRETAÇÃO CONFORME A CONSTITUIÇÃO DIANTE DA LEI FEDERAL 14.320/2021
Authors: Gustavo Gonçalves Caires Felipe , Da Rosa Ziesemer Henrique
Published: April 2023

Este artigo pretende demonstrar a necessidade de adotar-se a técnica de interpretação conforme a Constituição para que a definição dos atos de improbidade administrativa por violação de princípios da Administração Pública, trazida pela nova Lei de Improbidade Administrativa, abranja condutas funcionais de agentes públicos consideradas crimes dolosos, de modo que, a um tempo só, não se desfigure a proteção conferida pela Constituição Federal à probidade e à moralidade administrativas tampouco se prejudiquem a segurança e previsibilidade jurídicas objetivadas pela nova legislação.
Palavras-Chave: Improbidade administrativa. Moralidade administrativa. Princípios constitucionais da Administração Pública. Improbidade por violação de princípios. Lei Federal 14.230/2021. Interpretação conforme a Constituição.
 
Abstract
This article intends to demonstrate, from a constitutional approach, the necessity to implement the technique known as ‘interpretation in accordance to the Constitution’ to ensure that the constitutional protection afforded to administrative probity and morality, including the protection against crimes perpetrated by public employees or administrators, does not fade away, or even does not be obliterated, especially after the recent new Brazilian Anticorruption Statute in Public Affairs has re-defined and restrained the concept of acts of misconduct in public sector which seriously violate constitutional principles of public management.
Keywords: Administrative improbity. Administrative morality. Constitutional principles of public administration. Misconduct for violation of principles. Federal Statute 14.230/2021. Interpretation according to the Constitution.
Cost-effectiveness of IMI/CIL/REL for the treatment of carbapenem non-susceptible Gram-negative bacterial infections
Authors: Paoletti Martina , Marcellusi Andrea , Yang Joe , Mennini Francesco Saverio
Published: April 2023

Objective: The objective of this analysis was to evaluate the cost-effectiveness of imipenem/cilastatin/relebactam compared to colistin-imipenem in the treatment of hospitalized patients with Gram-negative bacterial infections caused by imipenem-resistant pathogens. The perspective was both that of the National Health Service (NHS) and the social one.
Methodology: A mixed model was developed to simulate a cohort of patients capable of highlighting the impacts of the disease on the quality of life and the absorption of economic resources of the patients in analysis. Modelled patients were those with hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia (HABP/VABP), complicated intra-abdominal infection (cIAI) or complicated urinal tract infection (cUTI) caused by carbapenem-resistant Gram-negative (GN) pathogens. The model begins with a short-term decision tree describing possible treatment routes and outcomes for patients during the hospitalization period. Patients who are healed in the decision tree enter the long-term Markov model, designed to capture the follow-up costs and health-related quality of life (HRQL) of patients healed over their lifetime.
Results: The analysis, conducted on a hypothetical cohort of 1,000 patients, highlights how the use of imipenem/cilastatin/relebactam is advantageous both in terms of diagnosis and treatment in the short term and in terms of cost-effectiveness. In fact, it is dominant compared to colistin-imipenem both in the NHS and in the social perspective since, compared to an average saving of € 2,800.15 and € 3,174.63 respectively, it would generate an increase of 4.76 years of life and of 4.12 QALYs per patient.
Hospital Management of the Eastern Mexico Regional Administrative Operating Body in the Sars-Cov-2 Pandemic: Technical Efficiency
Authors: Dichi-Romero María de los Ángeles , García-Cortés Luis Rey , Ramos-Valle David , Ramos-Ortega Gregorio , Ramos-Dichi Diana Gabriela , Vázquez-Raposo Alan Suresh , Palafox-Lagunas Erika Liliana
Published: April 2023

Introduction: In the face of the new health emergency due to SARS-COV-2, the Mexican Social Security Institute (IMSS) Spanish acronym, implements the Institutional Strategic Plan for Contingency Care due to COVID-19, which defines the modes of action in preparation and response in the presence and sustained SARS-COV-2 disease transmission cases Data envelopment analysis makes it possible to estimate the technical efficiency of service production systems. Objective: to estimate the technical efficiency of the hospital units of the Eastern Mexico State Regional Decentralized Administrative Operation Body of the IMSS (Spanish acronym) in the response to the SARS-COV-2 health contingency from March 2020 to March 2021. Methods: The COOPER Methodological Ordering was applied to define the input-oriented BCC model and estimate the hospitals’ technical efficiency in the treatment response of COVID-19 during 1st and 2nd periods of highest incidence. Inputs: Hospitalized and Covid-19 beds. Outputs: improvement/death ratio. Results: in the study period, 30,656 were hospitalized and 1,324 Covid-19 beds were managed in 10 hospitals. Improvement 15,067; death 15,589 (improvement/death ratio: 0.97). Average technical efficiency: 82%. Conclusions: 8 of 10 hospitals in technical efficiency. Data envelopment analysis enables health managers to estimate the production capacity of health services and decision-making in the event of a public health emergency.
Right-Sided May-Thurner Syndrome in a Patient with Left-Sided Inferior Vena Cava and Recent COVID-19 Infection
Authors: Ryan Senese , Iris Lu , Jonathan Saavedra , Steven Lev , K Ramanathan Anantha
Published: April 2023

Background: May-Thurner Syndrome (MTS) is a rare vascular condition where the left common iliac vein is compressed between the right common iliac artery and the spine. We report a case of a patient with a left-sided inferior vena cava and right-sided May-Thurner syndrome. He had recent symptomatic COVID infection despite vaccination (Janssen). Case: A 28-year-old male presented with right lower extremity pain and swelling for three weeks. A duplex ultrasound was performed revealing iliofemoral deep vein thrombosis. Pharmacomechanical thrombectomy with ultrasound assisted thrombolysis was performed with subsequent femoral venogram and angioplasty of the right common iliac vein. Conclusion: May-Thurner Syndrome often remains underdiagnosed due to the chronic nature of the disease process. The presence of a left-sided IVC leading to right sided MTS with recent COVID-19 infection (and vaccination) was a unique feature of this case. May-Thurner Syndrome should be considered in the differential diagnosis of those present with DVTs or symptoms of venous hypertension.
A Rare Case Report of Acute Uterine Inversion
Authors: Onuminya Dorcas Salime , Eifediyi Reuben Agbons
Published: April 2023

Background: Uterine inversion is a rare obstetric emergency with associated high maternal morbidity and mortality if intervention is delayed. The low incidence of uterine inversion results in sparse experience in resolving this obstetric emergency. There are many treatment strategies, but they are poorly described. The aim of this paper is to describe a rare case of acute uterine inversion and discuss it's management. Methods: A rare case report of acute uterine inversion following delivery in a multiparus woman which was treated promptly by obstetric team intervention with good outcome. Results: We were able to recognize the acute inversion of the uterus postpartum and offered manual uterine reversal using Johnson maneuver at an early stage without complications. The risk factor for uterine inversion was the fundal implantation of the placenta. Conclusions: The best management options for acute inversion of the uterus are not known, it is however important to keep in mind this diagnosis and be updated about the strategies required to achieve uterine reversal at an early stage.
Conservative Treatment with Double Pig Tail Placement in a Patient with an Iatrogenic Lesion of the Distal Ureter
Authors: Nervi Renzo , Pereyra Wilson , Rodriguez Nicanor , Plaza Stephanie , Rojas Gianella Romero
Published: April 2023

Iatrogenic ureteral injury (IUI) is a potentially devastating complication of open and laparoscopic surgery of the abdominal cavity, with open hysterectomy being the procedure that most frequently leads to these injuries [1]. Treatment options for IUI include percutaneous nephrostomy in patients unsuitable for immediate surgical exploration, PIG- TAIL placement for traction injuries without ischemia, and open surgical repair of the injured ureter [2]. We present the case of a 46-year-old female patient who, after a laparoscopic hysterectomy, presented a grade 2 injury in the distal third of the right ureter, which caused chemical peritonitis due to uroperitoneum, repaired with 2 PIG - TAIL COOK FIRM, under cystoscopic and fluoroscopic guidance, leaving Jackson-Pratt drain in the abdominal cavity and a patent Foley catheter, with subsequent reoperation to remove the ureteral stent, observing good healing of the distal ureter and preserved renal function.
MİMARLIK FAKÜLTESİ ÖĞRENCİLERİNİN UZAKTAN EĞİTİM SÜRECİNDE YAŞADIKLARI ERGONOMİK SORUNLAR
Authors: GİRESUN ERDOĞAN Buket , KUTSAL Simge , ÖZGEL FELEK Seval
Published: April 2023

2019 yılının son günlerinde ortaya çıkan küresel Covid-19 salgını nedeniyle Mart 2020 tarihi itibari ile üniversite öğrencileri zorunlu olarak uzaktan eğitim almak durumunda kalmışlardır. Bu zorunlu süreçte öğrencilerin eğitim verimliliği, memnuniyeti, çalışma performansları gibi çeşitli faktörler, sahip oldukları fiziksel, mekânsal, sosyal şartlardan etkilenmiştir. Bu çalışmada; mimarlık fakültelerinde önemli bir yeri olan atölye çalışmalarını, konut ortamlarında gerçekleştirmek zorunda kalan öğrencilerin içinde bulundukları ergonomik koşullar irdelenmiştir. Yıldız Teknik Üniversitesi Mimarlık Fakültesi öğrencileri üzerinde araştırma yapılmıştır. Literatür taramasında öğrencilerin karşılaşabilecekleri birtakım sorunlar: antropometrik ve duyusal olarak belirlenmiştir. Betimsel araştırma yöntemi ile yapılan çalışmada, verileri toplamak için oluşturulan anket çevrimiçi olarak iletilmiş; 212 öğrencinin cevapları dikkate alınmıştır. Araştırma sonucuna göre antropometrik sorunların (n=4,55) ve görsel sorunların (n=4,38) görülme sıklığı yüksektir. İşitsel sorunlar (n=3,54) ve termal koşullara bağlı sorunlarla (ngüz=2,73 nbahar=3,32) ise orta sıklıkta karşılaşılmaktadır. Bu sorunların giderilmesi için öneriler geliştirilmiştir.
KULLANICI DENEYİMi VE ETKİLEŞİM FAKTÖRLERİNE GÖRE HEPSİBURADA PLATFORMUNUN TASARIM HATALARININ İNCELENMESİ
Authors: YILDIZ Orkun
Published: April 2023

Bu çalışmada, örnek olay olarak ele alınan bir e-ticaret platform firmasının tasarım hataları keşfine yönelik bir araştırma gerçekleştirilmiştir. Bu kapsamda, Türkiye’nin en yüksek ticari iş hacmine sahip olan e-ticaret platform sitesi olan Hepsiburada firmasının web sitesi ve mobil uygulama platformları örnek olay olarak ele alınmıştır. Bu araştırma, kullanıcı deneyimi ile kullanıcı etkileşimi için ergonomik bir tasarım gereksinimlerini belirten faktörel boyutlara dayalı bir şekilde gerçekleştirilmiştir. Bu doğrultuda, amacımıza uygun bir şekilde amaçsal örnekleme göre katılımcılar belirlenmiş, bir alışveriş senaryosu ile kullanım rehberi hazırlanmıştır. Alışveriş senaryosuna göre kullanım rehberi çerçevesinde katılımcılar alışverişlerini gerçek zamanlı olarak laboratuvar ortamında gerçekleştirilmiştir. Araştırma metodu, bilişsel izlenecek yol analizi tercih edilmiştir. Bu kapsamda, her bir katılımcıdan sesli düşünme, gözlem ve not alma olmak üzere farklı araçlar aracılığıyla veriler elde edilmiştir. Elde edilen verilerin analizi sonucunda kullanıcı deneyimi ve kullanıcı etkileşimi bakımından farklı kategorilerde web sitesinde beş adet ve mobil uygulamada ise on adet tasarım hatası tespit edilmiştir. Web sitesinde kelime ve görsel temsil, estetik, psikolojik, davranış ve algısallık yönünden hataların olduğu bulgusuna ulaşılmıştır. Diğer yandan, mobil sitede ise, algısallık, görsel temsil, fiziksellik, estetik, fiziksel nesneler, fonksiyonellik, kelime karakter tasarımlarına yönelik hataların olduğu da tespit edilmiştir. Bu bulguların her birisi müşteri kullanım memnuniyeti ve marka sadakati üzerinde etkileri olabilecek hatalar olduğu söylenebilir.
Correlação entre urocultura e sumário de urina para o diagnóstico de infecção do trato urinário em pacientes Internos num Hospital Universitário do Estado da Paraíba
Authors: Silva Viviane Araújo , Souza Brenda Kettinly Ferreira , Silva Larissa Rodrigues dos Santos , Araújo Ana Paloma Tavares de , Nunes Francisco Cunha , Aragão Neto Humberto de Carvalho , Tavares Nathalia de Alencar Cunha
Published: April 2023

A infecção do trato urinário (ITU) é uma das mais frequentes que acometem os pacientes internos em ambiente hospitalar, podendo ser classificada como cistite ou pielonefrite, de acordo com o sítio da infecção. O Diagnóstico da ITU é feito basicamente pela realização do sumário de urina (EAS) e da urocultura. Sendo assim, o objetivo deste trabalho foi realizar estudo retrospectivo no período de janeiro/2021 a dezembro/2021 com base no banco de dados do laboratório de análises clínicas do Hospital Universitário Lauro Wanderley (HULW) no estado da Paraíba em relação às alterações apresentadas no exame de EAS, principalmente com os marcadores nitrito e esterase leucocitária de uroculturas positivas. Também foi observado os dados epidemiológicos dessas infecções, assim como a incidência bacteriana das mesmas. Obteve-se um total de 1817 exames de Uroculturas realizados, sendo que 837 exames apresentavam solicitação de EAS concomitantemente, e destas 129 amostras de urocultura foram positivas sendo os microrganismos prevalente as Escherichia coli (36,5%), Klebsiella pneumoniae (20,6%) e Pseudomonas aeruginosa (8,7%). O nitrito foi observado em 16% das amostras e a esterase leucocitária em 58%. Concluímos que quanto aos resultados do EAS, a leucocitúria revelou-se um marcador mais sensível para auxílio diagnóstico de ITU em relação ao nitrito, corroborando com a literatura científica especializada, com predomínio de ITU em pacientes do sexo feminino.
Educação no contexto das restrições sanitárias: analisando as políticas do estado de Goiás na educação básica em 2020
Authors: Cardoso Jane Alves
Published: April 2023

O objetivo deste trabalho é analisar as políticas adotadas pelo governo do Estado de Goiás na área da educação durante o período de restrições sanitárias provocadas pela pandemia da Covid-19, com foco no ano letivo de 2020. Em particular, discutiremos o Regime Especial de Aulas Não Presenciais (REANP) para os alunos da rede estadual, oferecido por meio do portal oficial da Secretaria de Educação do Estado de Goiás (SEDUC), apontando os limites e as possibilidades desse modelo para uma educação de qualidade mediada pelo uso das Tecnologias Digitais de Informação e Comunicação (TDICs). A pesquisa realizada teve caráter exploratório e bibliográfico. Evidenciamos as regularidades, discrepâncias e intensidades das ações e políticas impulsionadas durante o período e publicadas na página oficial da SEDUC. Concluímos que existem muitos obstáculos à universalização e à permanência dos alunos nesse modelo de ensino mediado pelas novas TDICs e pelo contexto de restrições sanitárias. As desigualdades sociais são os principais limites dessa política, influenciando na condição de quem pode ou não acompanhar o ensino nessa modalidade, o que pode interferir no desenvolvimento educacional do estado nos próximos anos. Além disso, destacamos as possibilidades de utilização da internet e das novas tecnologias para incrementar a educação básica, construindo possibilidades de literacia e alfabetização digital para os estudantes, professores e gestores educacionais. Essas possibilidades devem ser exploradas de maneira mais ampla, permitindo a oferta de conteúdos diversificados, o desenvolvimento de habilidades e competências digitais e o acesso à educação de qualidade para todos os alunos.
Epigenetic Mechanisms in Sjögren’s Syndrome
Authors: Le Dantec Christelle , Charras Amandine , Bordron Anne , Brooks Wesley , Renaudineau Yves
Published: April 2023

Primary Sjögren’s syndrome (pSS) is a systemic autoimmune epithelitis and recent advances in our comprehension of its pathophysiology strongly suggest a multi-step process that involves environmental factors (e.g. chronic viral infection, drugs), followed by deregulation of the epigenetic machinery (e.g. DNA demethylation, histone modifications, microRNAs), which in turn specifically affects lymphocytes and epithelial cells leading to an aberrant inflammation. This process is amplified in the case of genetic mutations. As a consequence, autoreactive lymphocytes and autoantigens are produced leading to the development of autoantibodies. Moreover, it was observed that epigenetic modifications in pSS could be reversed, thus providing arguments to suggest that therapeutic strategies targeting the epigenetic deregulation and in particular the PKC-delta/Erk/DNMT1 pathway would be effective in pSS.
Avanafil: The Second-Generation Treatment of Erectile Dysfunction
Authors: Corona Giovanni , Maggi Mario , Jannini Emmanuele A.
Published: April 2023

The main objectives of erectile dysfunction (ED) management are to control and reduce associated organic cardiovascular risk factors and to restore the capacity to obtain and maintain a rigid penile erection.

Since oral phosphodiesterase (PDE)-5 inhibitors have a demonstrated efficiency in the number and duration of erections in patients with ED with a favourable benefit-to-risk ratio, they have been recommended in European guidelines as the first-line medical therapy for ED.

In January 2016, we published a comprehensive review and meta-analysis on the safety and efficacy of avanafil, a novel second-generation PDE-5 inhibitor. This review aims to shed a special spotlight on the key aspects of this meta-analysis and to discuss how avanafil can provide an added value in the management of ED over first-generation agents.
From Bench to Bedside: Targeting the IL-1β Pathway in Autoinflammatory Diseases
Authors: McEvoy Lynda
Published: April 2023

Prof Gerd Horneff opened the symposium with a summary of the recent advances in the understanding of the role of interleukin (IL)-1β in the pathogenesis of autoinflammatory (AI) diseases. Prof Angelo Ravelli then discussed the concept of ‘treat-to-target’ in systemic juvenile idiopathic arthritis (SJIA) and the various tools that can be used for monitoring treatment response. Dr Jasmin B Kümmerle-Deschner followed with an overview of the efficacy and safety data from the β-Confident Registry of patients with cryopyrin-associated periodic syndromes (CAPS) receiving treatment with canakinumab. Prof Fabrizio De Benedetti concluded with an overview of the up-and-coming data in the field of AI diseases. The objectives of the symposium were to summarise new insights in the pathogenesis of AI diseases including the role of IL-1β; to evaluate the use of anti-IL-1β and other treatment options for AI diseases; to describe the treat-to-target concept and recognise the potential of a tight disease control strategy in patients with SJIA; to integrate new knowledge on the long-term use of canakinumab in patients with CAPS based on the latest β-Confident Registry data; and to discuss management strategies in patients with AI diseases.
Optimising Patient Outcomes Throughout the Rheumatoid Arthritis Patient Journey: The Exception, the Standard, and the Rule
Authors: Sweetlove Melanie
Published: April 2023

Prof Peter Taylor opened the symposium focussed on optimisation of treatment for rheumatoid arthritis (RA) at each stage of the patient’s journey. Prof Ronald van Vollenhoven reviewed the evidence for first- line biologics in the ‘exceptional patient’ and explored which patients may be suitable for such treatments. Prof Taylor then expanded on how use of such treatments could be optimised and when to introduce biologic therapy for the so-called ‘standard’ patient. Finally, Prof Daniel Aletaha discussed treatment options and targets for patients who have failed on a biologic as ‘the rule’ in the treatment of RA.
TÜRKİYE-NATO İLİŞKİLERİNDE VETO KRİZLERİ: BENZERLİKLER VE FARKLILIKLAR ÜZERİNE BİR DEĞERLENDİRME
Authors: OVALI Ali Şevket
Published: April 2023

Rusya’nın Ukrayna’yı işgalinin tam ortasında Türkiye’nin İsveç ve Finlandiya’nın NATO üyeliği teşebbüsüne itiraz etmesi ittifak içerisinde ciddi bir krize neden olmuştur. Kriz her ne kadar Türkiye, Finlandiya ve İsveç arasında imzalanan üçlü mutabakat metni ile çözülmüşse de Ankara’nın sıkça veto kartına başvurması ittifakın üyeleri arasında büyük kaygı yaratmıştır. Bu kaygılar NATO üyeleri arasında karar alma mekanizmalarına dair reform gerekliliği tartışmalarını alevlendirmiş ve Türkiye’nin ittifakın sorun çıkaran üyesi olarak tanımlanmasına neden olmuştur. Medyada yer alan haberlere göre Türkiye, 2009 ve 2022 arasında en az altı NATO kararını veto etmiştir. Veto krizlerinin sayısı ve sıklığı Türkiye’nin vetoyu önemli bir dış politika yapma enstrümanı olarak kullandığı ve gelecekte de bu şekilde kullanabileceğini göstermektedir. Çalışma, bu varsayımdan hareketle, Türkiye-NATO ilişkilerindeki veto krizlerini mukayese ederek Türk dış politikası üzerine var olan literatüre katkıda bulunmayı hedeflemektedir. Çalışma bu bağlamda veto krizleri arasında benzerlik ve farklılıkları, her veto vakasının sebepleri, kısa vadeli etkileri ve sonuçlarını tartışarak ortaya koymayı da amaçlamaktadır. Çalışmada karşılaştırmalı vaka analizi yöntemi kullanılacak ve bulgular altı vaka üzerinden değerlendirilecektir
The Development of Artificial Intelligence and Software Education Programs for Liberal Arts College: Focusing on Learners’ Needs Analysis
Authors:   The Korean Society of Culture and Convergence, Park Sohyun , Kim Sijung , Park Hyunjun
Published: April 2023

This study aims to develop AI․SW liberal arts subjects for university learners based on the analysis of learners' needs for artificial intelligence and software education. To analyze learners' educational needs, a survey was conducted on learners at A University. Based on the analysis, the AI․SW liberal arts subjects was designed to combine learning theory of artificial intelligence and Python practice. The theory of artificial intelligence focuses on the development process and service cases to increase the interest of learners. It helps learners explore ways to use artificial intelligence in their field. And Python practice is to create results by modifying the source code to reduce the burden of beginners. In the long term, it helps learners integrate artificial intelligence into their majors. This study presents basic research for a liberal arts curriculum that creates talents who can converge artificial intelligence in each academic field.
A Study on the Cultural Education of Warrior(武人)'s Sijo(時調) in the Joseon Dynasty period(朝鮮時代)
Authors:   The Korean Society of Culture and Convergence, Cho Seongyoon
Published: April 2023

This study sought cultural education of the three dimensional Sijo(時調), focusing on Sijo(時 調), who could examine the new culture of the warriors(武人) of the Joseon Dynasty period(朝 鮮時代). Just because the founder of a warrior, you should not educate only the themes of spirit and loyalty as a warrior. It was emphasized that various contents should be educated for in-depth exploration and deep understanding of the culture of literature. Therefore, it was suggested that the Sijo(時調) culture, which the warriors sang with the gisaengs at the feast while working at the border, or the Sijo(時調) of various themes sung in their life after retirement, should be educated along with related records.
Effects of K-POP Orientation and BTS Identification on K-POP Satisfaction and Korea’s Country Brand Attitude
Authors:   The Korean Society of Culture and Convergence, Yun Yeongsam , Jun Jongwoo
Published: April 2023

This study investigated how the perception of K-POP and BTS affects the satisfaction of K-POP and attitude toward Korea targeting Indonesians. As a result of the survey, it was found that people with a high degree of remote acculturation were satisfied with K-POP and had a positive attitude toward Korea. People with high sensation-seeking orientation and cognitive-seeking orientation had high satisfaction with K-POP and had a positive attitude toward Korea. However, those with high social-seeking orientation tended to have negative attitudes toward Korea. When the level of identification with BTS was high, it was found that they were satisfied with K-POP. Lastly, those familiar with Korean culture were satisfied with K-POP and had a positive attitude toward Korea. These results reveal the antecedent factors that affect K-POP satisfaction and provide implications for the impact on Korea’s country brand attitude.
Spatial Narratives and Storytelling Characteristics of Local Cultural Contents
Authors:   The Korean Society of Culture and Convergence, Kim Jayoung , Kwon Byungwoong , Kim Sooyong
Published: April 2023

Local cultural resources are accompanied by economic and cultural values as well as social values. Therefore, this study focused on storytelling among cultural content development strategies to secure regional competitiveness. To this end, the core role of storytelling was examined through literature research. In addition, the physical elements of the local space and the narrative structure of storytelling were explored for the Gangneung area, and the relational characteristics between the two elements were analyzed. The direction of Gangneung's spatial storytelling derived through analysis is as follows. First, the density of spatial experience is strengthened by storytelling accompanied by interactivity. Therefore, the necessity of discovering and developing various storytelling to revitalize the local space was confirmed. Second, physical and temporal constraints of spatial experience are inevitable. Therefore, it is necessary to develop various contents using digital media to overcome place limitations. Third, various discourse on space strengthens the connection between space and people and content while aggregating space and visitors, and induces visitors' participation and immersion in space. In addition, communication and immersion in space expand the role of visitors as the subject and communicator of experience production. Therefore, it is required to develop long-term and systematic local cultural contents using storytelling and establish strategies for utilization.
A Study on Needs Analysis of the Adult Competencies Required for Career Interrupted Women in Korea
Authors:   The Korean Society of Culture and Convergence, Kim Jungwon , Cho Daeyeon , Park Jiwon , Chang Eunha
Published: April 2023

The purpose of this paper is to perform the needs analysis of adult competencies for career interrupted women and to provide information on priority group competencies of them. The subjects of this study were 241 women in 17 cities and provinces across the country, and sampling was conducted using a stratified random sampling method. For the research method, the t-test, Borich needs assessment, and The Locus for Focus model suggested by Cho (2009) were systemically employed to identify the priorities. As a result of the analysis, there were 10 competencies belonging to both the Borich needs assessment and The Locus for Focus model, and two competencies among them, financial management competency and digital utilization competency, were derived as the highest priority competencies. Next, competencies corresponding to only one of the two techniques were selected as second priority competencies. Based on the results of this study, implications for development of customized lifelong education programs for career interrupted women were suggested.
The Diffusion of 3D Printing Technology in Korean Industry: Implications for Outdoor Advertising and Sculpture Art Industry
Authors:   The Korean Society of Culture and Convergence, Hyun Eunjung
Published: April 2023

This study examines the direction and extent of the diffusion of 3D printing technology in various industries by conducting a comprehensive analysis of domestic 3D printing patents and bibliographic research from 2000 to 2019. 3D printing technology has the potential to revolutionize the way products are designed, developed and manufactured across a wide range of industries. We show that it is likely to have a significant impact on the sculpture art and outdoor advertising sector as 3D printing technology is increasingly being used in product design, architecture, and art. Overall, this study highlights the breadth and depth of the impact that 3D printing technology is likely to have across a wide range of industries, and the potential for it to drive innovation and growth in the coming years.
Re-reading Huxley's 'Brave New World' with Idea of the Good: The Meaning of Education in Post-human Era
Authors:   The Korean Society of Culture and Convergence, Wang Chunlei
Published: April 2023

The book 'Sapiens' written by Yuval Harari, it's argued that the Homo species was able to shape human history due to their desire to alter their destiny through continuous revolution. By relying on cutting-edge science and technology to enhance human physical and mental abilities, human capacities have been transformed beyond recognition. This phenomenon is analogous to the current situation in which science and technology have permeated people's lives and significantly altered their lifestyles. This is particularly evident after the four industrial revolutions. Consequently, the challenge facing humanity extends beyond humans to non-human entities. In 1932, 'Brave New World' was published, which depicted a society dominated by science and technology. It allows us to re-examine ourselves and understand the significance of human existence in future society characterized by science and technology. This report focuses on the novel's unreasonable educational systems, which reflect some of the current educational situations in society. Plato, an ancient Greek philosopher, emphasized the importance of education and the educational process through three metaphors. His theory is also applicable in the current social environment of scientific development. From an educational perspective, we must ask ourselves what goodness is and find our own answers. The education of goodness represents the true meaning of our current social education.
The Effect of Purchase Preference Factors on Satisfaction according to Mask Style Interest
Authors:   The Korean Society of Culture and Convergence, Kim Jinil , Kwon Kihan
Published: April 2023

In a pandemic situation, masks have proven to us globally the diverse cultural values of life protection and fashion items. The purpose of this study was to understand the effect of purchase preference factors on satisfaction according to the style interest of masks during the pandemic. As a research method, SPSS25.0 statistical program was used for 373 adult men and women. As a result of the study, as the interest in style increased, the preference for color, design, brand, advertising media, and quality, excluding price, increased. In addition, it was confirmed that satisfaction also increased as the perception of each factor of overall purchase preference increased. This suggests that the attitude of changing perception of mask fashion is positive according to the new change in the mask consumption market. In the future, research on mask development focusing on sustainability reflecting consumer needs is needed, and this study is expected to be an important basic data for follow-up research.
The Effect of Socio-economic Status on Health Status of the Elderly: The Sequential Mediating Effect of Social Activity Participation and Cognitive Function
Authors:   The Korean Society of Culture and Convergence, Lee Jooyeon
Published: April 2023

This study attempted to verify the sequential mediating effect of social activity participation and cognitive function in the effect of the socioeconomic status of the elderly on health status. The subjects of the analysis were 3,364 out of 4,405 valid samples of the 8th Korean Longitudinal Study of Aging, which removed missing values for the elderly aged 65 or older. For statistical analysis, PROCESS macro v.4.1 program model 6 and SPSS 25.0 program were used. As a result of verifying the significance of the sequential mediating effect of social activity participation and cognitive function, the total indirect effect of socioeconomic status on health status, the mediating effect of social activity participation in socioeconomic status, and the sequential mediating effect of socioeconomic status. As a result of this study, implications for finding a practical method that can prevent or improve the deterioration of the health status of the elderly were proposed.
Analysis of ESG-Related Research Trends and Exploration of Ways to Link Information Sharing Values
Authors:   The Korean Society of Culture and Convergence, Kim Yukyung , Kim Hanjib
Published: April 2023

This study is intended to provide implications through information sharing value connection plans in the process of establishing a company's ESG-related social value basic plan and evaluation system. Through this, we tried to present implications from a mid- to long-term perspective so that companies, investors, and the government can properly link the ESG agenda. As a result of this study, in order to actively and actively promote action plans for ESG, it is necessary to prepare conditions for individual companies to propose and implement actionable measures in detail through information sharing. Above all, in order to do ESG integrated management well, information sharing should precede what companies can do by practicing specific activities.
How does the psychiatrist know?
Authors: Kind Adrian
Published: April 2023

An important question in the philosophy of psychiatry is: what is the proper method of psychiatric diagnostic reasoning? Let us call this the Methodological Question. In this paper, I criticize the answer that proponents of phenomenological psychiatry have given to this question and present an alternative. I argue that their answer fails to meet several adequacy conditions for a theory of psychiatric diagnostic reasoning. I then show how my own answer to the Methodological Question – the Model-Based Account of diagnostic reasoning – meets these adequacy conditions. I conclude that the Model-Based Account of diagnostic reasoning is preferable to the Phenomenological Account.
A BIBLIOMETRIC ANALYSIS OF HRM SYSTEMS AND FIRM INNOVATION
Authors: Yang Zhang  , Stephen J. J. McGuire
Published: April 2023

In this paper, we explored the bibliometric network structure in the major literature on human resource management (HRM) systems and firm innovation.  In the search of Web of Science, we identified 173 unique papers, including quantitative papers, qualitative papers, literature review, editorial letters, etc. The VOS viewer bibliometric results showed three clusters of firm innovation from the HRM systems perspective: innovation in products or services, innovation in processes, and innovation in people and organizations. Our paper also described the number of publications, co-authorship information, and affiliated universities and countries per firm innovation cluster.
HALAL COSMETICS INDUSTRY FOR SUSTAINABLE DEVELOPMENT: A SYSTEMATIC LITERATURE REVIEW
Authors: Adlin Masood  , Sri Rahayu Hijrah Hati  , Alina Abdul Rahim
Published: April 2023

In 2019, Muslim expenditure on halal cosmetics reached USD66 billion globally and projected to attain USD75 billion in 2024 (GIER 2020/21) thus representing a substantial and sustainable opportunity for nations seeking economic security. Many halal cosmetics SMEs have venture into this emerging sector, but not all were successful. Halal cosmetics sector is still in its infancy thereby few literature reviews have been conducted worldwide to evaluate research gaps in the halal cosmetics and skincare business domain. The present study integrated multiple methods analysis and the publication standard ROSES (RepOrting standards for Systematic Evidence Syntheses). This study used bibliographic databases namely Scopus, ScienceDirect, Google Scholar and Springer Link. Only 31 articles from 761, met the criteria and were studied, revealing five main themes that were subdivided into 19 sub-themes. The outcome of this systematic review process enables identification of existing knowledge breach in the field, serves as the basis for conducting future research on halal cosmetics and skin care in a systematic manner, and paves the way towards doing further research to assist policy makers and business sectors to close the apparent gap. This understanding will enable emerging nations to achieve sustainable development goals through halal cosmetics industry.
THE EFFECT OF SOCIAL PROGRESS ON FOREIGN DIRECT INVESTMENTS: A DYNAMIC PANEL DATA ANALYSIS FOR AFRICAN COUNTRIES
Authors: Teheni El Ghak  , Abderazak Bakhouche
Published: April 2023

A strand in the empirical literature on development economics investigates the dependence of foreign direct investments on recipient countries' economic, institutional and structural characteristics. This paper builds upon this literature by examining the role of a country's social progress as a pull factor for inward foreign investments.  It applies the dynamic panel data methodology to an unbalanced panel dataset from African countries for the 2011-2019 period. The findings suggest that social progress is a significant determinant of foreign direct investments in Africa, supporting a positive social progress-foreign direct investments nexus. For the dimensions of social progress, while access to basic needs and foundations of well-being are important factors, opportunity exhibits superior influence on foreign direct investments. Findings provide evidence for a policy that recognises the social progress in shaping a host country’s attractiveness to foreign investments.
Life experiences of boars can shape the survival, aggression, and nociception responses of their offspring
Authors: Sabei Leandro , Bernardino Thiago , Parada Sarmiento Marisol , Barbosa Bruna Stanigher , Farias Sharacely de Souza , Ghantous Giovana Fumes , de Lima César Gonçalves , Poletto Rosangela , Zanella Adroaldo José
Published: April 2023

Introduction

Boars are often housed in stressful environments on commercial farms, experiencing poor welfare. These conditions may cause epigenetic changes in the boars' gametes, which could potentially be transmitted to their offspring. We aimed to investigate the effect of three different boars housing environments on the survival, aggression, and nociceptive responses of their offspring.

Methods

For four weeks, 18 boars were housed in three different systems: crates (C;n=6), pens (P;n=6), and enriched pens (E;n=6). The environmental enrichment was provided twice daily (brushing, shower, and hay). Thirteen gilts were housed in outdoor paddocks and inseminated with pooled semen from the boars kept in the three treatments. We evaluated the number of live-born, stillborn, and weaned piglets, sex, and mortality rate. Weaning was performed at 29 days of age. For each piglet, six body photographs were taken for five days postweaning to measure skin lesions (n=138). On Day 34, the nociceptive pressure threshold was assessed using an analgesimeter (n=138). DNA paternity tests were carried out at the end of the study (n=181). A generalized linear model with a negative binomial distribution was used to compare the number of live-born/weaned piglets and skin lesions among the treatment groups. We used a Kruskal‒Wallis test to analyze nociceptive data.

Results

More live-born and weaned piglets were fathered from boars kept in the E group than the P group (p=0.002;p=0.001, respectively). A trend was observed in the number of skin lesions on the left side of piglets (P<C;p=0.053). For nociceptive assessments, offspring from P boars showed less right leg withdrawal than piglets from E and C boars (p=0.008); the P group had a higher average nociceptive value than the C group (p=0.002). All treatments differed in the region adjacent to the tail for nociceptive pressure threshold (P>E>C;p<0.001).

Discussion and conclusion

Our results suggest that providing an enriched environment for boars can increase the number of live-born and weaned piglets. Moreover, the boars housing conditions can influence nociceptive threshold in their offspring. Further research must be performed to understand the underlying mechanism associated with these changes using epigenetics protocols and measuring physiological indicators and other molecular markers in semen and/or sperm cell samples.