bluuebunny/crossref_metadata_2025 huggingface dataset:
Vision-based SLAM system for MAVs in GPS-denied environments
Authors: Urzua Sarquis , Munguía Rodrigo , Grau Antoni
Published: June 2017

Using a camera, a micro aerial vehicle (MAV) can perform visual-based navigation in periods or circumstances when GPS is not available, or when it is partially available. In this context, the monocular simultaneous localization and mapping (SLAM) methods represent an excellent alternative, due to several limitations regarding to the design of the platform, mobility and payload capacity that impose considerable restrictions on the available computational and sensing resources of the MAV. However, the use of monocular vision introduces some technical difficulties as the impossibility of directly recovering the metric scale of the world. In this work, a novel monocular SLAM system with application to MAVs is proposed. The sensory input is taken from a monocular downward facing camera, an ultrasonic range finder and a barometer. The proposed method is based on the theoretical findings obtained from an observability analysis. Experimental results with real data confirm those theoretical findings and show that the proposed method is capable of providing good results with low-cost hardware.
Pilot report: non-operative treatment of Mayo Type II olecranon fractures in any-age adult patient
Authors: Putnam Matthew D. , Christophersen Christy M. , Adams Julie E.
Published: June 2017

Background

We report on the non-operative treatment of Mayo Type II olecranon fractures.

Methods

Fourteen isolated Mayo Type II olecranon fractures were treated non-operatively, followed to discharge, and retrospectively reviewed. Treatment was splinting in extension followed by protected active motion beginning 3 weeks to 4 weeks post-injury. Mayo Elbow Performance Index (MEPI) and Shortened Disabilities of the Arm, Shoulder and Hand (QuickDASH) scores were available in 86% and 64% of cases, respectively. Follow-up radiographs were obtained.

Results

At discharge, the mean (SD) MEPI score was 95 (5). The mean (SD) elbow motion arc was 121° (21°). One patient re-fractured his elbow after discharge by falling on the ice. He recovered after open reduction and internal fixation. One patient (documented Marfan syndrome) developed an asymptomatic non-union. Excepting the patient who fell, no patient received additional care.

Conclusions

In this pilot report, Mayo Type II olecranon fractures were treated non-operatively to discharge. Good to excellent results were obtained in all patients according to the MEPI. Supportive care of these fractures should be comparatively studied. A downside risk to providing supportive care for these fractures was not identified.
Organizational knowledge and capabilities in healthcare: Deconstructing and integrating diverse perspectives
Authors: Evans Jenna M , Brown Adalsteinn , Baker G Ross
Published: June 2017

Diverse concepts and bodies of work exist in the academic literature to guide research and practice on organizational knowledge and capabilities. However, these concepts have largely developed in parallel with minimal cross-fertilization, particularly in the healthcare domain. This contributes to confusion regarding conceptual boundaries and relationships, and to a lack of application of potentially useful evidence. The aim of this article is to assess three concepts associated with organizational knowledge content—intellectual capital, organizational core competencies, and dynamic capabilities—and to propose an agenda for future research. We conducted a literature review to identify and synthesize papers that apply the concepts of intellectual capital, organizational core competencies, and dynamic capabilities in healthcare settings. We explore the meaning of these concepts, summarize and critique associated healthcare research, and propose a high-level framework for conceptualizing how the concepts are related to each other. To support application of the concepts in practice, we conducted a case study of a healthcare organization. Through document review and interviews with current and former leaders, we identify and describe the organization’s intellectual capital, organizational core competencies, and dynamic capabilities. The review demonstrates that efforts to identify, understand, and improve organizational knowledge have been limited in health services research. In the literature on healthcare, we identified 38 papers on intellectual capital, 4 on core competencies, and 5 on dynamic capabilities. We link these disparate fields of inquiry by conceptualizing the three concepts as distinct, but overlapping concepts influenced by broader organizational learning and knowledge management processes. To aid healthcare researchers in studying and applying a knowledge-based view of organizational performance, we propose an agenda for future research involving longitudinal comparative case studies.
Ketogenic diet: Predictors of seizure control
Authors: Agarwal Nitin , Arkilo Dimitrios , Farooq Osman , Gillogly Cynthia , Kavak Katelyn S , Weinstock Arie
Published: June 2017

Background:

The ketogenic diet is an effective non-pharmacologic treatment for medically resistant epilepsy. The aim of this study was to identify any predictors that may influence the response of ketogenic diet.

Methods:

A retrospective chart review for all patients with medically resistant epilepsy was performed at a tertiary care epilepsy center from 1996 to 2012. Patient- and diet-related variables were evaluated with respect to seizure reduction at 1, 3, 6, 9 and 12-month intervals and divided into four possible outcome classes.

Results:

Sixty-three patients met inclusion. Thirty-seven (59%) reported >50% seizure reduction at 3 months with 44% and 37% patients benefiting at 6-month and 12-month follow up, respectively. A trend toward significant seizure improvement was noted in 48% patients with seizure onset >1 year at 12-month (p = 0.09) interval and in 62% patients with >10 seizure/day at 6-month interval (p = 0.054). An ordinal logistic regression showed later age of seizure to have higher odds of favorable response at 1-month (p = 0.005) and 3-month (p = 0.013) follow up. Patients with non-fasting diet induction were more likely to have a favorable outcome at 6 months (p = 0.008) as do females (p = 0.037) and those treated with higher fat ratio diet (p = 0.034).

Conclusion:

Our study reports the effectiveness of ketogenic diet in children with medically resistant epilepsy. Later age of seizure onset, female gender, higher ketogenic diet ratio and non-fasting induction were associated with better odds of improved seizure outcome. A larger cohort is required to confirm these findings.
Intimate Surveillance: Normalizing Parental Monitoring and Mediation of Infants Online
Authors: Leaver Tama
Published: June 2017

Parents are increasingly sharing information about infants online in various forms and capacities. To more meaningfully understand the way parents decide what to share about young people and the way those decisions are being shaped, this article focuses on two overlapping areas: parental monitoring of babies and infants through the example of wearable technologies and parental mediation through the example of the public sharing practices of celebrity and influencer parents. The article begins by contextualizing these parental practices within the literature on surveillance, with particular attention to online surveillance and the increasing importance of affect. It then gives a brief overview of work on pregnancy mediation, monitoring on social media, and via pregnancy apps, which is the obvious precursor to examining parental sharing and monitoring practices regarding babies and infants. The examples of parental monitoring and parental mediation will then build on the idea of “intimate surveillance” which entails close and seemingly invasive monitoring by parents. Parental monitoring and mediation contribute to the normalization of intimate surveillance to the extent that surveillance is (re)situated as a necessary culture of care. The choice to not survey infants is thus positioned, worryingly, as a failure of parenting.
Matrix-Assisted Autologous Chondrocyte Transplantation in the Knee: A Systematic Review of Mid- to Long-Term Clinical Outcomes
Authors: Schuette Hayden B. , Kraeutler Matthew J. , McCarty Eric C.
Published: June 2017

Background:

Matrix-assisted autologous chondrocyte transplantation (MACT) is a surgical treatment option for articular cartilage lesions of the knee joint.

Purpose:

To investigate mid- to long-term clinical outcomes of MACT in the patellofemoral (PF) and tibiofemoral (TF) joints.

Study Design:

Systematic review; Level of evidence, 4.

Methods:

A systematic review was performed by searching PubMed, Embase, and the Cochrane Library to find studies evaluating minimum 5-year clinical outcomes of patients undergoing MACT in the knee joint. Search terms used were knee, matrix, and autologous chondrocyte. Patients were evaluated based on treatment failure rates, magnetic resonance imaging, and subjective outcome scores. Study methodology was assessed using the Modified Coleman Methodology Score (MCMS).

Results:

Ten studies (two level 1, one level 2, one level 3, and six level 4 evidence) were identified that met inclusion and exclusion criteria, for a total of 442 TF patients and 136 PF patients. Treatment failure occurred in 9.7% of all patients, including 4.7% of PF patients and 12.4% of TF patients ( P = .037). Weighted averages of subjective outcome scores, including Knee injury and Osteoarthritis Outcome Score, Short Form–36 Health Survey, and Tegner scores, improved from baseline to latest follow-up in both TF and PF patients. The mean MCMS was found to be 57.4, with a standard deviation of 18.5.

Conclusion:

Patients undergoing MACT in the knee show favorable mid- to long-term clinical outcomes. A significantly higher treatment failure rate was found in patients undergoing MACT in the TF joint compared with the PF joint.
What do we (do not) know about the use of cone beam computed tomography in endodontics? A thematic series with a call for scientific evidence
Authors: Kamburoğlu Kıvanç , Tsesis Igor , Rosen Eyal
Published: June 2017

Cone beam computed tomography (CBCT) has become a common diagnostic method in endodontics. However, the current literature provides insufficient information about different aspects that are related to the use of CBCT, such as: the efficacy of CBCT to support the practitioner’s clinical decision making and to affect treatment outcomes; about the required training of the practitioner so he can efficiently examine the entire region that appears in the CBCT scan and diagnose abnormalities or possible pathologies; and on the long-term health risks associated with the use of CBCT in endodontics. In addition, CBCT has the strong potential to be used for accurate diagnosis of complete and uneventful healing. In this thematic series, we call for manuscripts that discuss aspects of the use of CBCT in endodontics.
Postmating sexual selection and the enigmatic jawed genitalia of Callosobruchus subinnotatus
Authors: van Haren Merel M. , Rönn Johanna Liljestrand , Schilthuizen Menno , Arnqvist Göran
Published: June 2017

Insect genitalia exhibit rapid divergent evolution. Truly extraordinary structures have evolved in some groups, presumably as a result of post-mating sexual selection. To increase our understanding of this phenomenon, we studied the function of one such structure. The male genitalia of Callosobruchus subinnotatus (Coleoptera: Bruchinae) contain a pair of jaw-like structures with unknown function. Here, we used phenotypic engineering to ablate the teeth on these jaws. We then experimentally assessed the effects of ablation of the genital jaws on mating duration, ejaculate weight, male fertilization success and female fecundity, using a double-mating experimental design. We predicted that copulatory wounding in females should be positively related to male fertilization success. However, we found no significant correlation between genital tract scarring in females and male fertilization success. Male fertilization success was, however, positively related to the amount of ejaculate transferred by males and negatively related to female ejaculate dumping. Ablation of male genital jaws did not affect male relative fertilization success but resulted in a reduction in female egg production. Our results suggest that postmating sexual selection in males indeed favors these genital jaws, but not primarily through an elevated relative success in sperm competition but by increasing female egg production.
Sorting through Search and Matching Models in Economics
Authors: Chade Hector , Eeckhout Jan , Smith Lones
Published: June 2017

Toward understanding assortative matching, this is a self-contained introduction to research on search and matching. We first explore the nontransferable and perfectly transferable utility matching paradigms, and then a unifying imperfectly transferable utility matching model. Motivated by some unrealistic predictions of frictionless matching, we flesh out the foundational economics of search theory. We then revisit the original matching paradigms with search frictions. We finally allow informational frictions that often arise, such as in college-student sorting. (JEL C78, D82, D83, I23, J12)
Community and Code: Nine Lessons from Nine NESCent Hackathons
Authors: Stoltzfus Arlin , Rosenberg Michael , Lapp Hilmar , Budd Aidan , Cranston Karen , Pontelli Enrico , Oliver Shann , Vos Rutger A.
Published: June 2017

In recent years, there has been an explosion in the popularity of hackathons — creative, participant-driven meetings at which software developers gather for an intensive bout of programming, often organized in teams. Hackathons have tangible and intangible outcomes, such as code, excitement, learning, networking, and so on, whose relative merits are unclear. For example, a frequent complaint is that code is abandoned when the hackathon ends, and questions like, “which outcomes are produced most reliably?” and, “how valuable are they for participants, organizers, and sponsors?” remain open. As a first step in giving “hackology” a more rigorous footing, this paper describes the NESCent hackathon model, developed over the course of a decade to serve the academic discipline of evolutionary biology, with the dual goals of augmenting the community’s shared software infrastructure, and fostering a diverse community of practice in open scientific software development. The paper presents a detailed guide to staging a NESCent-style hackathon, along with a structured information set on nine events involving 54 team projects. NESCent hackathons have produced tangible products with downstream impacts, including prototypes that were leveraged for major funding, incremental additions to production code bases, and creative drafts (designs, standards, and proofs-of-concept) that contributed to further work. The impacts of intangible outcomes could not be assessed objectively, but the subjective experience suggests that hackathons have a positive impact by (1) providing individuals with valuable experiences, networking, and training, and (2) fostering a more cohesive community of practice by enhancing awareness of challenges and best practices and by building links of familiarity between and among resources and people. Future research that recognizes the diverse outcomes of hackathons might enable evidence-based decisions about how to design hackathons for effectiveness.
A multi-tool recipe to identify regions of protein-DNA binding and their influence on associated gene expression
Authors: Carlin Daniel E. , Kosnicki Kassi , Garamszegi Sara , Ideker Trey , Thorvaldsdóttir Helga , Reich Michael , Mesirov Jill P.
Published: June 2017

One commonly performed bioinformatics task is to infer functional regulation of transcription factors by observing differential expression under a knockout, and integrating DNA binding information of that transcription factor.   However, until now, this this task has required dedicated bioinformatics support to perform the necessary data integration. GenomeSpace provides a protocol, or “recipe”, and a user interface with inter-operating software tools to identifying protein occupancies along the genome from a ChIP-seq experiment and associated differentially regulated genes from an RNA-Seq experiment. By integrating RNA-Seq and ChIP-seq analyses, a user is easily able to associate differing expression phenotypes with changing epigenetic landscapes.
Improved deconvolution of very weak confocal signals
Authors: Day Kasey J. , La Rivière Patrick J. , Chandler Talon , Bindokas Vytas P. , Ferrier Nicola J. , Glick Benjamin S.
Published: June 2017

Deconvolution is typically used to sharpen fluorescence images, but when the signal-to-noise ratio is low, the primary benefit is reduced noise and a smoother appearance of the fluorescent structures. 3D time-lapse (4D) confocal image sets can be improved by deconvolution. However, when the confocal signals are very weak, the popular Huygens deconvolution software erases fluorescent structures that are clearly visible in the raw data. We find that this problem can be avoided by prefiltering the optical sections with a Gaussian blur. Analysis of real and simulated data indicates that the Gaussian blur prefilter preserves meaningful signals while enabling removal of background noise. This approach is very simple, and it allows Huygens to be used with 4D imaging conditions that minimize photodamage.
Study protocol: A multi-centre, double blind, randomised, placebo-controlled, parallel group, phase II trial (RIDD) to determine the efficacy of intra-nodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with an embedded dose response study.
Authors: Nanchahal Jagdeep , Ball Catherine , Swettenham Jennifer , Dutton Susan , Barber Vicki , Black Joanna , Copsey Bethan , Dritsaki Melina , Taylor Peter , Gray Alastair , Feldmann Marc , Lamb Sarah
Published: June 2017

Dupuytren’s disease is a common fibrotic condition of the hand affecting 4% of the population and causes the fingers to curl irreversibly into the palm. It has a strong familial tendency, there is no approved treatment for early stage disease, and patients with established digital contractures are most commonly treated by surgery. This is associated with prolonged recovery, and less invasive techniques have high recurrence rates.The myofibroblasts, the cells responsible for the excessive matrix deposition and contraction, are aggregated in nodules. Using excised diseased and control human tissue, we found that immune cells interspersed amongst the myofibroblasts secrete cytokines. Of these, only tumour necrosis factor (TNF) promoted the development of myofibroblasts. The clinically approved anti-TNF agents led to inhibition of the myofibroblast phenotypein vitro. This clinical trial is designed to assess the efficacy of the anti-TNF agent adalimumab on participants with early disease. The first part is a dose-ranging study where nodules of participants already scheduled for surgery will be injected with either placebo (saline) or varying doses of adalimumab. The excised tissue will then be analysed for markers of myofibroblast activity.The second part of the study will recruit participants with early stage disease. They will be randomised 1: 1 to receive either adalimumab or placebo at 3 month intervals over 1 year and will then be followed for a further 6 months. Outcome measures will include nodule hardness, size and disease progression. The trial will also determine the cost-effectiveness of adalimumb treatment for this group of participants.
The effect of imatinib therapy on tumour cycling hypoxia, tissue oxygenation and vascular reactivity
Authors: Gonçalves Miguel R. , Johnson Sean Peter , Ramasawmy Rajiv , Lythgoe Mark F. , Pedley R. Barbara , Walker-Samuel Simon
Published: June 2017

Background: Several biomedical imaging techniques have recently been developed to probe hypoxia in tumours, including oxygen-enhanced (OE) and blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI). These techniques have strong potential for measuring both chronic and transient (cycling) changes in hypoxia, and to assess response to vascular-targeting therapies in the clinic.

Methods: In this study, we investigated the use of BOLD and OE-MRI to assess changes in cycling hypoxia, tissue oxygenation and vascular reactivity to hyperoxic gas challenges, in mouse models of colorectal therapy, following treatment with the PDGF-receptor inhibitor, imatinib mesylate (Glivec).

Results: Whilst no changes were observed in imaging biomarkers of cycling hypoxia (from BOLD) or chronic hypoxia (from OE-MRI), the BOLD response to carbogen-breathing became significantly more positive in some tumour regions and more negative in other regions, thereby increasing overall heterogeneity.

Conclusions: Imatinib did not affect the magnitude of cycling hypoxia or OE-MRI signal, but increased the heterogeneity of the spatial distribution of BOLD MRI changes in response to gas challenges.
Governance Practices in Platform Ecosystems: Navigating Tensions Between Cocreated Value and Governance Costs
Authors: Huber Thomas L. , Kude Thomas , Dibbern Jens
Published: June 2017

Based on an exploratory multiple-case study in two platform ecosystems, we develop a process theory that explains how and why different ways of practicing ecosystem-wide governance are more or less successful in navigating the tension between cocreated value and governance costs. Our process theory shows that how ecosystem-wide rules and values are practiced considerably varies and changes over time. Initially, governance practices follow ecosystem-wide rules; if and how practices shift toward going beyond the rules hinges on specific necessary conditions. Irrespective of which governance route is taken, the tension between cocreated value and governance costs is more successfully addressed if practices are sensitive to ecosystem-wide values.

The online appendix is available at https://doi.org/10.1287/isre.2017.0701 .
Making sense of charts
Authors: Davis John
Published: June 2017

This is the first of a four-part series, which provides opportunities for pupils to learn the skills involved in analysing text and data presented in visual formats.
La «observación» electoral de la OEA vs. el «acompañamiento» de UNASUR en las recientes elecciones de Venezuela
Authors: Pascual Planchuelo Víctor Carlos
Published: June 2017

La observación electoral se ha convertido en un ejercicio esencial para el desarrollo de la democracia electoral. La proliferación de organizaciones que monitorizan elecciones obliga a distinguir entre la genuina actividad de «observación electoral» de otras actividades similares, tales como el «acompañamiento electoral». La independencia es un elemento esencial que deben respetar las misiones genuinas de observación de elecciones. La falta de independencia las transforma en misiones de «observación electoral intervenida», las cuales adolecen de una menor credibilidad y fiabilidad. Así, los últimos procesos electorales celebrados en Venezuela nos aportan la base fáctica necesaria para diferenciar las misiones de observación de la oea de las misiones de acompañamiento de unasur.
No alineamiento, tercermundismo y seguridad en Perú: la política exterior del gobierno de Juan Velasco Alvarado (1968-1980)
Authors: Alburquerque Germán
Published: June 2017

El objetivo de este artículo es, por una parte, constatar que el ingreso de Perú al Movimiento de los Países No Alineados supuso la irrupción de un nuevo paradigma en la política exterior no solo de ese país, sino de América Latina entera; por otra, establecer que tras la nueva política hubo un discurso ideológico apropiado y reelaborado, el tercermundismo, que le brindó una base sólida y un relato funcional a sus fines.
Stems age, nitrogen fertilizer and salicylic acid application in cutting induction of noble dendrobium orchid of the Yamamoto series cultivars
Authors: Soccol Jeferson João , Venturieri Giorgini Augusto , Pedrotti Enio Luiz
Published: June 2017

Propagation of noble dendrobium orchid (Dendrobium nobile Lindl.) by cutting was studied in two experiments. In the first experiment we evaluated the effect stem age on propagation success: mature stems - from already bloomed stems; and young stems – yet to bloom; and Nitrogen fertilizer application, from two sources: as Nitrate and Ammonium (respectively as Calcium Nitrate at concentrations of: 5.81 gL-1; 11.61 gL-1; 17.42 gL-1; and Urea at concentrations of 2.00 gL-1; 4.00 gL-1 and 6.00 gL-1 plus control treatments). We evaluated the following parameters: the number of cuttings stalks that launched shoots and/or roots, vigor, number of roots per plant and root length per plant. Factorial analysis of variance (stems age x source of Nitrogen; and age of stem x Nitrogen level) was applied using a Generalized Linear Model (GLM) approach. Where significant differences were observed, averages were compared using post-hoc tests (Tukey). Propagation success was higher using cuttings from mature stems (60.2%), a value 1.6 times higher than obtained with stem cuttings from young stems (38.0%). Application of Nitrogen, in both forms, did not influence any of the evaluated parameters. In the second experiment we treated cuttings from mature stems with Salicylic acid in 3 concentrations (0.10 mM; 0.50 mM; 1.00 mM and plus a control treatment). Evaluated parameters included proportion of cuttings stalks that launched shoots and/or roots, leaf length, root length, and number of roots per stem cutting. Factorial analysis of variance was applied with post-hoc tests. Application of 0.50 mM of Salicylic acid increased the proportion of cuttings stalks that launched shoots and/or roots by 20.5% relative to the control treatment.
Caracterización de la enfermedad de la artritis y encefalitis caprina en las provincias de Salta y Jujuy
Authors: DODERO Ana M. , MICHELOUD Juan F. , ALFARO José R , ALFARO Emilio J , PINTO Gabriel B , SUAREZ Victor H.
Published: June 2017

La artritis y encefalitis Caprina (CAEV) puede presentar diferentes síntomas clínicos, siendo la artritis la más común. A fin de caracterizar la presencia de enfermedades en las majadas caprinas del noroeste argentino, se llevó a cabo una encuesta sanitaria a productores, con toma de muestras biológicas para el diagnóstico de enfermedades en la que fue incluida CAEV. Se efectuó un análisis serológico con un ELISA indirecto y se completó con un examen clínico general de los animales y toma de muestra de necropsia de algunos de los casos. En la Provincia de Salta, tres establecimientos fueron positivos, con un 6,25% de prevalencia. La seroprevalencia del hato con seguimiento de caso fue del 55% mientras que el 48% presentó signos clínicos donde la artritis de la articulación carpal fue la más frecuentemente afectada. El virus CAEV está distribuido en la provincia de Salta y la severidad de las lesiones observadas sugiere la presencia de nuevas cepas que deben ser investigadas conjuntamente al desarrollo de capacidades locales para el diagnóstico, clave de cualquier plan de erradicación.
Finite Genus Solutions to the Generalised Kaup-Newell Hierarchy and Two 2+1 Dimensional Modified Korteweg-de Vries Equations
Authors: Yang Xiao , Han Jiayan
Published: June 2017

A generalised Kaup-Newell (gKN) hierarchy is introduced, which starts with a system of first-order ordinary differential equations and includes the Gerdjikov-Ivanov equation. By introducing an appropriate generating function, its related Hamiltonian systems and algebraic curve are given. The Hamiltonian systems are proved to be integrable, then the gKN hierarchy is solved by Hamiltonian flows. The algebraic curve is provided with suitable genus, then based on the trace formula and Riemann-Jacobi inversion theorem, finite genus solutions of the gKN hierarchy are obtained. Besides, two 2+1 dimensional modified Korteweg-de Vries (mKdV) equations are also solved.
GABA-B Controls Persistent Na+Current and Coupled Na+-Activated K+Current
Authors: Li Ping , Stewart Richard , Butler Alice , Gonzalez-Cota Ana Laura , Harmon Steve , Salkoff Lawrence
Published: June 2017

The GABA-B receptor is densely expressed throughout the brain and has been implicated in many CNS functions and disorders, including addiction, epilepsy, spasticity, schizophrenia, anxiety, cognitive deficits, and depression, as well as various aspects of nervous system development. How one GABA-B receptor is involved in so many aspects of CNS function remains unanswered. Activation of GABA-B receptors is normally thought to produce inhibitory responses in the nervous system, but puzzling contradictory responses exist. Here we report that in rat mitral cells of the olfactory bulb, GABA-B receptor activation inhibits both the persistent sodium current (INaP) and the sodium-activated potassium current (IKNa), which is coupled to it. We find that the primary effect of GABA-B activation is to inhibit INaP, which has the secondary effect of inhibiting IKNabecause of its dependence on persistent sodium entry for activation. This can have either a net excitatory or inhibitory effect depending on the balance of INaP/IKNacurrents in neurons. In the olfactory bulb, the cell bodies of mitral cells are densely packed with sodium-activated potassium channels. These channels produce a large IKNawhich, if constitutively active, would shunt any synaptic potentials traversing the soma before reaching the spike initiation zone. However, GABA-B receptor activation might have the net effect of reducing the IKNablocking effect, thus enhancing the effectiveness of synaptic potentials.
Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment
Authors: Lemons Kayla , Fu Ziying , Aoudé Imad , Ogura Tatsuya , Sun Julianna , Chang Justin , Mbonu Kenechukwu , Matsumoto Ichiro , Arakawa Hiroyuki , Lin Weihong
Published: June 2017

The mammalian main olfactory epithelium (MOE) modifies its activities in response to changes in the chemical environment. This process is essential for maintaining the functions of the olfactory system and the upper airway. However, mechanisms involved in this functional maintenance, especially those occurring via paracrine regulatory pathways within the multicellular MOE, are poorly understood. Previously, a population of non-neuronal, transient receptor potential M5-expressing microvillous cells (TRPM5-MCs) was identified in the MOE, and the initial characterization of these cells showed that they are cholinergic and responsive to various xenobiotics including odorants at high concentrations. Here, we investigated the role of TRPM5-MCs in maintaining olfactory function using transcription factor Skn-1a knockout (Skn-1a-/-) mice, which lack TRPM5-MCs in the MOE. Under our standard housing conditions, Skn-1a-/-mice do not differ significantly from control mice in odor-evoked electro-olfactogram (EOG) responses and olfactory-guided behaviors, including finding buried food and preference reactions to socially and sexually relevant odors. However, after a 2-wk exposure to high-concentration odor chemicals and chitin powder, Skn-1a-/-mice exhibited a significant reduction in their odor and pheromone-evoked EOG responses. Consequently, their olfactory-guided behaviors were impaired compared with vehicle-exposed Skn-1a-/-mice. Conversely, the chemical exposure did not induce significant changes in the EOG responses and olfactory behaviors of control mice. Therefore, our physiological and behavioral results indicate that TRPM5-MCs play a protective role in maintaining the olfactory function of the MOE.
The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance
Authors: Wang Baiping , Li Hongmei , Mutlu Sena A. , Bowser Devon A. , Moore Michael J. , Wang Meng C. , Zheng Hui
Published: June 2017

The amyloid precursor protein (APP) is a receptor-like membrane protein. Although APP processing and β-amyloid production play a central role in Alzheimer’s disease (AD) pathogenesis, the physiological function of APP remains elusive. Here, we identify APP as a novel receptor for Slit that mediates axon guidance and neural circuit formation. APP deficiency abolishes the Slit repulsive effect in a 3D olfactory explant culture, consistent with its callosal projection deficit in vivo and reminiscent of Slit loss. Inactivation of APP ortholog APL-1 inCaenorhabditiselegans results in pioneer axon mistargeting and genetic analysis places APL-1 in the SLT-1 (Slit)/SAX-3 (Robo) repulsive pathway. Slit binds to APP through the E1 domain, which triggers APP ectodomain shedding and recruitment of the intracellular FE65 and Pak1 complex and associated Rac1 GTPase activation. Our study establishes APP as a novel receptor for Slit ligand mediating axon guidance and neural circuit formation.
The Doors of the Chapel and the Keys to the Palace of Louis IX
Authors: Cohen Meredith
Published: June 2017

The Doors of the Chapel and the Keys to the Palace of Louis IX considers two virtually unknown sculpted portals located in the second bay on the north side of the Sainte-Chapelle, the monumental reliquary chapel built by Louis IX in the royal palace of Paris between 1239 and 1248. Examining archaeological and archival documentation concerning these portals, Meredith Cohen provides important new insights about the initial design and function of the Sainte-Chapelle, its attendant structures, and the royal palace. After charting the history of the Chevesserie, the building to which the portals issued, Cohen proposes a relative chronology for the other structures in the palace attributed to Louis IX, arguing that construction of the Sainte-Chapelle generated major changes, which defined the palace as symbol of the royal state starting in the thirteenth century. This article contributes to the research in medieval architecture that views great monuments as part of highly complex historical topographies.
Evolution of SOI MOSFETs: from Single Gate to Multiple Gates
Authors: Colinge Jean-Pierre
Published: June 2017

To improve short-channel characteristics and increase current drive, SOI technology is shifting focus from “classical” single-gate MOSFET architectures to multiple-gate device structures. This paper traces the history of single- and multiple-gate SOI MOSFETs and summarizes the electrical characteristics of such devices.
Scalability of MOCVD-deposited Hafnium Oxide
Authors: Elshocht S. Van , Carter R. , Caymax M. , Claes M. , Conard T. , Daté L. , Gendt S. De , Kaushik V. , Kerber A. , Kluth J. , Lujan G. , Pétry J. , Pique D. , Richard O. , Rohr E. , Shimamoto Y. , Tsai W. , Heyns M.M.
Published: June 2017

Because of aggressive downscaling to increase transistor performance, the physical thickness of the SiO2 gate dielectric is rapidly approaching the limit where it will only consist of a few atomic layers. As a consequence, this will result in very high leakage currents due to direct tunneling. To allow further scaling, materials with a k-value higher than SiO2 (“high-k materials”) are explored, such that the thickness of the dielectric can be increased without degrading performance.

Based on our experimental results, we discuss the potential of MOCVD-deposited HfO2 to scale to (sub)-1-nm EOTs (Equivalent Oxide Thickness). A primary concern is the interfacial layer that is formed between the Si and the HfO2, during the MOCVD deposition process, for both H-passivated and SiO2-like starting surfaces. This interfacial layer will, because of its lower k-value, significantly contribute to the EOT and reduce the benefit of the high-k material. In addition, we have experienced serious issues integrating HfO2 with a polySi gate electrode at the top interface depending on the process conditions of polySi deposition and activation anneal used. Furthermore, we have determined, based on a thickness series, the k-value for HfO2 deposited at various temperatures and found that the k-value of the HfO2 depends upon the gate electrode deposited on top (polySi or TiN).

Based on our observations, the combination of MOCVD HfO2 with a polySi gate electrode will not be able to scale below the 1-nm EOT marker. The use of a metal gate however, does show promise to scale down to very low EOT values.
A New Parameter Predicating Gm for Ultra Thin Nitrided Gate Oxide
Authors: Hori Mitsuaki , Tamura Naoyoshi , Kase Masataka , Sakuma Hiroko , Ohota Hiroyuki , Shigeno Mayumi , Kataoka Yuuzi
Published: June 2017

We propose a new parameter predicating transconductance (Gm) of the gate dielectric of nitrided SiO2 with the physical thickness below 1.1 nm for high-performance transistors. The 6 different type of nitrided SiO2 are formed using the plasma nitridation or nitric oxide (NO) gas annealing in conditions to adjust a optical thickness ranging 0.96 to 1.19 nm. The material property of nitrided SiO2 are analyzed by secondary ions mass spectroscopy (SIMS) and x-ray photoelectron spectroscopy (XPS). The MOSFET are fabricated using these gate dielectric and 90 nm generation CMOS technology. Then we find a good correlation between the maximum of Gm and the percentage of amount of N(SiN3)3 substructure at the total amount of NSi3 structure measured by XPS, rather than the total dose of nitrogen measured by SIMS.
LS-MOCVD of BSTO Thin Films Using Novel Ba and Sr Precursors
Authors: Kwon Hyun Goo , Oh Youngwoo , Park Jung Woo , Lee Young Kuk , Kim Chang Gyoun , Kim Yunsoo
Published: June 2017

We report the synthesis of new precursors Ba(thd)2(tmeea) and Sr(thd)2(tmeea), where tmeea = tris[2-(2-methoxyethoxy)ethyl]amine, and the LS-MOCVD of barium strontium titanate (BSTO) thin films using these precursors. Thin films of BSTO were grown on Pt(111)/SiO2/Si(100) substrates by LS-MOCVD using the cocktail source consisting of the conventional Ti precursor Ti(thd)2(OiPr)2 and the new Ba and Sr precursors. As-grown films were characterized by SEM, XRD, XRF, and C-V measurement. BSTO films grown at 420°C were stoichiometric barium strontium titanate with very smooth surface morphology and their dielectric constants were found to be as large as 320. The dependence of composition, microstructure and the electrical properties of the BSTO films on the growth temperature, annealing temperature, and working pressure will be discussed.
Kinetics Of Charge Generation During Formation Of Hf And Zr Silicate Dielectrics
Authors: Gougousi Theodosia , Kelly M. Jason , Parsons Gregory N.
Published: June 2017

Understanding charged defects in high dielectric constant insulators is a critical challenge for advanced devices. We have formed thin Zr and Hf silicates by oxidation of thin metal films sputtered on clean Si(100) and studied the effect of oxidation time (15 to 300s) and temperature (600 or 900°C) on the flatband voltage using capacitance vs. voltage measurements. We find that the thermal budget during oxidation and the type of oxidizing agent (slow vs. fast) affect the amount of fixed charge in the film significantly. Oxidation of 0.8nm of Zr metal on Si at 600°C in N2O for 15s results in EOT=1.2nm and a shift in the flatband voltage by ∼-0.2V indicating generation of positive fixed charge. Oxidation of similar films for 300s result in EOT=2.8nm and shift of the flatband voltage by ∼-0.95V. Hf films oxidized in N2O also show increased concentrations of fixed charge for longer oxidation times. By comparison, Si oxidized in the same environment does not show this extent of flatband voltage shift. A significantly reduced charge generation rate is observed for Hf oxidation under low O2 partial pressure. Extended oxidations (up to 1h) result in increased EOT and a slight decrease in the charged defect state density. Forming Gas Anneal (FGA) results in partial neutralization of the charge. FGA after the Al gate deposition also leads to significant decrease of the EOT (from 2.7 to 2.1nm) indicating significant reaction of the film with the gate metal. X-ray photoelectron spectroscopy for thin films indicates formation of Zr and Hf-silicates. However, for thick Hf films the low O2 oxidation process results in less silicon incorporation in the film as compared to films oxidized in N2O. Results suggest that understanding oxidation mechanisms will be important in isolating andcontrollingfixedchargeinhigh-kdielectrics.
Free Standing Silicon as a Compliant Substrate for SiGe
Authors: Cohen G. M. , Mooney P. M. , Chu J.O.
Published: June 2017

We show that SiGe grown on free-standing silicon is elastically relaxed. The free-standing Si structure consists of a ∼30 nm-thick, 5 μm-square silicon slab supported by a SiO2 pedestal at a single contact point at the center of the square (the cross-section resembles a mushroom). A matrix of free-standing structures was made by patterning a bonded silicon-on-insulator (SOI) wafer and undercutting the SiO2 to form the pedestal. Un-patterned areas of the SOI wafer and the exposed bulk Si substrate were included as reference regions. A UHVCVD Si0.8Ge0.2 film, about 200 nm-thick, was grown epitaxially on both sides of the free-standing silicon and the surrounding exposed bulk Si. The SiGe was also grown on the un-patterned SOI and bulk substrate control areas. The SiGe film grown on both SOI and bulk silicon was found to be fully strained. In contrast, the SiGe layer grown on free-standing silicon is ∼89% strain-relaxed, and the free-standing silicon film was measured to be under tensile strain. Since the same lattice mismatch was found between the SiGe layer and the Si on the free-standing silicon and on the SOI and bulk Si control regions, we conclude that the strain relaxation of the SiGe film on free-standing Si is elastic with the strain accommodated entirely by the free-standing silicon film under tensile strain. This was further confirmed by AFM measurements. The SiGe film on the control regions showed a very smooth SiGe surface with only a few surface steps originating from misfit dislocations at the SiGe/Si interface. No surface steps from misfit dislocations were observed on the surface of the SiGe film on free-standing Si. These results show that free-standing silicon serves as an ideal compliant substrate for SiGe.
Short-period (Si14 / Si0.75 Ge0.25)20 Superlattices for the Growth of High-quality Si0.75 Ge0.25
Authors: Rahman M.M. , Tambo T. , Tatsuyama C.
Published: June 2017

In the present experiment, we have grown 2500-Å thick Si0.75Ge0.25 alloy layers on Si(001) substrate by MBE process using a short-period (Si14/Si0.75Ge0.25)20 superlattice (SL) as buffer layers. In the SL layers, first a layer of 14 monolayers (MLs) of Si (thickness about 20Å) then a thin layer of Si0.75Ge0.25 (thickness 5-6Å) were grown. This Si/(Si0.75Ge0.25) bilayers were repeated for 20 times. The buffer layers were grown at different temperatures from 300-400°C and the alloy layers were then grown at 500°C on the buffer layers. The alloy layer showed low residual strain (about -0.16%) and smooth surface (rms roughness ~15Å) with 300°C grown SL buffer. Low temperature growth of Si in SL layer introduces point defects and low temperature growth of Si1-xGex in SL layer reduces the Ge segregation length, which leads to strained SL layer formation. Strained layers are capable to make barrier for the propagation of threading dislocations and point defect sites can trap the dislocations.
Low Schottky Barrier on N-Type Si for N-Channel Schottky Source/Drain MOSFETs
Authors: Tao Meng , Udeshi Darshak , Agarwal Shruddha , Basit Nasir , Maldonado Eduardo , Kirk Wiley P.
Published: June 2017

Schottky source/drain (S/D) in Si-CMOS provide an alternative to current approaches in S/D, channel, and gate-stack engineering. The Schottky S/D PMOS has been demonstrated at a number of university and industrial laboratories. The bottleneck for the Schottky S/D NMOS is the fact that none of the common metals or metal silicides has a low enough barrier height (~0.2 eV) on n-type Si. A method to produce low Schottky barriers on n-type Si with common metals including aluminum (Al) and chromium (Cr) is reported in this paper. The interface between metal and Si(100) is engineered at the atomic scale with a monolayer of selenium (Se) to reduce the density of interface states, and the engineered interface shows inertness to chemical and electronic processes at the interface. One consequence of this electronic inertness is that the Schottky barrier is now more dependent on the metal work function. Al and Cr both have work functions very close to the Si electron affinity. It is found that the Schottky barrier of Al on Se-engineered n-type Si(100) is 0.08 eV, and that of Cr is 0.26 eV. These numbers agree well with the ideal Schottky barrier heights for Al and Cr on n-type Si(100), but are significantly different from the barrier heights known for four decades for these metals on n-type Si(100). These results bring new hope for the Schottky S/D NMOS with a metal commonly used in the Si industry.
GENETIC VARIATION AND POPULATION STRUCTURE IN THE HUMPBACK GROUPER, Cromileptes altivelis, TROUGHOUT ITS RANGE IN INDONESIAN WATERS
Authors: Sugama Ketut , Tridjoko Tridjoko , Haryanti Haryanti , Budi M Sari , Cholik Fuad
Published: June 2017

Starch gel electrophoresis was used to assess the level and distribution ofgenetic variation in humpback grouper, Cromileptes altiuelis sampled from 4 different areas of coral reefs in Raas and Kangean located in Madura as well as Sangeang and Bungin located in Sumbawa regions, between December 1997 and March 1998.
THE MINI SEINER FLEET OF THE NORTH JAVA COAST: A Case Study of Their Fishing Activities
Authors: Ecoutin Jean Marc , Dharmadi Dharmadi
Published: June 2017

Fishing effort is often a difficult parameter to identify in halieutic st,udies and even more so if the study involves coastal and artisanal frshing spread along a coast more than 1,000 km long.
CHLORINE DEMAND AND BACTERIAL ABUNDANCE OF SHRIMP POND WATER UNDER DIFFERENT SUSPENDED SOLID CONCENTRATIONS
Authors: Husnah Husnah
Published: June 2017

An experiment has been conducted to evaluate the chlorine demand and efficacy of 6 chlorine concentrations in brackish pond water, to control indigenous bacteria in shrimps pond.
THE USE OF MANGROVE STANDS FOR SHRIMP POND WASTE-WATER TREATMENT
Authors: Ahmad Taufik , Tjaronge Mohammad , Cholik Fuad
Published: June 2017

Degraded coastal environmental quality due to mangrove forest conversion is strongly suspected as a cause of the decline of shrimp pond productivity in lndonesia.
GROWTH AND NUTRIENT DIGESTIBlLITY OF JELAWAT (Leptobarbus hoeveni) FRY FED WITH VARIOUS DIETARY PROTEIN LEVELS
Authors: Sunarno Mas Tri Djoko
Published: June 2017

A growth and nutnent dtgesttbility study was executed for jelawat fry in the laboratory. The fry (40 day-old) were reared in 9 aquariums of 37.5L water volume at 30 per tank and fed an isocaloric diet(42kcal) contatning 3 dietary protein levels (33, 40, 47%) at 10% of body weigh tadayfor 49 days. Biomass was weighed fortnightly.
A New Look at the Old Problem of a Reasonable Expectation: The Reasonableness of Repeated Renewals of Fixed-Term Contracts as Opposed to Indefinite Employment
Authors: Gericke SB
Published: June 2017

In South Africa, the Labour Relations Act 66 of 1995 (LRA) regulates and protects the position of the employee who reasonably expects that a fixed-term contract will be renewed on the same or similar terms while the employer only offered to renew the contract on less favourable terms or in some instances was not prepared to renew the fixed-term contract at all. The LRA regards the latter conduct as a dismissal, as long as the employee can prove that the employer was responsible for creating the reasonable expectation of contractual renewal. In contrast to this position, the LRA does not regulate or protect the position of the employee whose fixed-term contract was repeatedly renewed on the same, similar or even improved terms, while the employer was in a position to offer the employee indefinite employment. The employer may even have created a reasonable expectation that repeated renewals would result in permanent employment. The exploitation and abuse of the fixed-term contract to the extent that an employee is deprived of employment security and the benefits linked to an employment relationship of indefinite duration have prompted a comparative investigation into this particular field of law.