bluuebunny/crossref_metadata_2025 huggingface dataset:
The Prevalence of Symptoms of Life-Threatening Events in Infants of the First Year of Life: a Cross-Sectional Population Study
Authors: Korableva Natalya N. , Pershina Ekaterina N. , Gusev Vladimir A.
Published: June 2019

Background.The prevalence of symptoms of life-threatening events in infants was previously studied using hospital data. However, not all parents in the event of such symptoms seek medical help in the hospital.

Objective.Our aim was to identify the prevalence and risk factors of life-threatening events in infants in the first year of life.

Methods.In the period from November 2017 to February 2018, we interviewed mothers who have children in their second year of life who are registered at children's outpatient clinics in Syktyvkar. Respondents noted episodes of absent, infrequent or irregular breathing, blanching or cyanosis of the skin, changes in muscle tone (hypo- or hypertonia), changes in the level of responses that occurred in infancy. The prevalence of symptoms of life-threatening events was estimated based on the total number of infants in the first year of life (n = 3088) who lived in Syktyvkar as of January 1, 2018.

Results.At least one symptom of life-threatening events in infancy was reported by 43 (4.3%) of the 1001 mothers surveyed. The prevalence of symptoms was 429.5 [95% confidence interval (CI) 321–574] per 10,000 children of the corresponding age. Independent predictors of life-threatening events in children of the first year of life were sudden deaths of relatives under the age of 50 years [odds ratio (OR) 2.4; 95% CI 1.1–5.3], cases of pre-syncope or syncope in relatives (OR 4.4, 95% CI 2.1–9.0), artificial feeding of infants (OR 4.0, 95% CI 1.5–11.2). The sensitivity of the model, which took into account the presence of at least one of the three predictors, was 19% (8/43), specificity — 99% (2/958).

Conclusion.The issue of the occurrence of life-threatening events in an infant can impact every 25th family. In every fifth infant, the occurrence of symptoms of life-threatening events can be predicted based on risk factors.
Geometrically non-linear vibration of concrete shallow funicular shells
Authors: Sabermahany Hadi , Mofid Massood , Daneshmand Niloofar
Published: June 2019

This study deals with the geometrically non-linear vibration analysis of concrete shallow funicular shells of rectangular plan with four clamped edges under impulse loads. The shape of a concrete funicular shell is such that the shell is subjected to pure compression under its dead weight. Following the existing method presented for the linear vibration analysis, the geometrically non-linear vibration analysis is considered through the use of non-linear shallow shells theory. Each displacement component is expanded in a double Fourier series and the kinetic energy, the elastic strain energy and the virtual work done by external forces are calculated in terms of the displacement components. Then, the equations of motion are obtained using the Lagrangian approach and are solved with the Runge–Kutta fourth-order method. The solution is verified against the results obtained with the finite-element method. The difference between the results of the linear and non-linear vibration analyses has been considered. Furthermore, it is indicated that under the considered dynamic loads, internal moments and consequentially tensile stresses are formed in the funicular shell and the shell does not behave purely as a funicular element. Finally, the plan aspect ratio effect on the time response of funicular shells has been shown.
Estimating elastic modulus of concrete with natural, recycled and secondary aggregates
Authors: Lye Chao-Qun , Dhir Ravindra K. , Ghataora Gurmel S.
Published: June 2019

The estimation of the elastic modulus of concrete is important in structural design. The characteristics of aggregate, especially its stiffness, have a profound influence on the elastic modulus of the concrete. However, this parameter is found not to be properly considered in the elastic modulus models used in current design codes, or in those developed by established organisations and individual researchers. In this study, the importance of stiffness and water absorption of natural aggregate and recycled and secondary aggregates are discussed. The parameters used in the existing elastic models are presented and three models, namely, ACI 209.2R-08, Eurocode 2 and B4, are assessed for their accuracy in estimating the elastic modulus of concrete made with both natural aggregate and recycled and secondary aggregates. A new empirical model essentially based on aggregate stiffness in the form of aggregate absorption, aggregate content and its ratio to cement content, has been developed for estimating the elastic modulus of concrete made with aggregate suitable for use in structural concrete.
Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex
Authors: Tossidou Irini , Teng Beina , Worthmann Kirstin , Müller-Deile Janina , Jobst-Schwan Tilman , Kardinal Christian , Schroder Patricia , Bolanos-Palmieri Patricia , Haller Hermann , Willerding Jonas , Drost Dana M. , de Jonge Laura , Reubold Thomas , Eschenburg Susanne , Johnson Ruth I. , Schiffer Mario
Published: June 2019

Significance Statement

The connection between the slit diaphragm and actin network of podocytic foot processes involves complex signaling between slit diaphragm proteins and multiple signaling pathways of the actin machinery. CD2AP, a slit diaphragm–associated scaffolding protein, is considered a “stabilizer” of the complex that connects the slit diaphragm protein nephrin to the cell’s cytoskeleton. In this study, the authors define CD2AP as a phosphorylation target of receptor tyrosine kinases stimulated by VEGF-A in podocytes. They demonstrate that phosphorylation of tyrosine at position Y10 of the SH3-1 domain of CD2AP can change the affinity of CD2AP to nephrin and is indispensable for CD2AP function and slit diaphragm functionalityin vivo. These findings implicate CD2AP phosphorylation as a molecular target in proteinuric kidney diseases.

Background

CD2-associated protein (CD2AP), a slit diaphragm–associated scaffolding protein involved in survival and regulation of the cytoskeleton in podocytes, is considered a “stabilizer” of the slit diaphragm complex that connects the slit diaphragm protein nephrin to the cytoskeleton of the cell. Tyrosine phosphorylation of slit diaphragm molecules can influence their surface expression, but it is unknown whether tyrosine phosphorylation events of CD2AP are also physiologically relevant to slit diaphragm stability.

Methods

We used isoelectric focusing, western blot analysis, and immunofluorescence to investigate phosphorylation of CD2AP, and phospho-CD2AP antibodies and site-directed mutagenesis to define the specific phosphorylated tyrosine residues. We used cross-species rescue experiments in Cd2apKDzebrafish and inDrosophila cindrRNAimutants to define the physiologic relevance of CD2AP phosphorylation of the tyrosine residues.

Results

We found that VEGF-A stimulation can induce a tyrosine phosphorylation response in CD2AP in podocytes, and that these phosphorylation events have an important effect on slit diaphragm protein localization and functionalityin vivo. We demonstrated that tyrosine in position Y10 of the SH3–1 domain of CD2AP is indispensable for CD2AP functionin vivo. We found that the binding affinity of nephrin to CD2AP is significantly enhanced in the absence of Y10; however, unexpectedly, this increased affinity leads not to stabilization but to functional impairment of the glomerular filtration barrier.

Conclusions

Our findings provide insight into CD2AP and its phosphorylation in the context of slit diaphragm functionality, and indicate a fine-tuned affinity balance of CD2AP and nephrin that is influenced by receptor tyrosine kinase stimulation.
Differentiated approach to the minimally invasive management of malignant obstructive jaundice
Authors: Galperin E. I. , Akhaladze G. G. , Vetshev P. S. , Dyuzheva T. G.
Published: June 2019

Attitude towards preoperative biliary drainage for malignant obstructive jaundice have recently changed twice. This is due certain factors including complications of minimally invasive biliary drainage, level of bile duct block, cholangitis, need for neoadjuvant chemotherapy, time to scheduled surgery, severe general condition of patient, future liver remnant volume. We comprehensively searched PUBMED, MD Consult and National Library of Medicine using the following keywords: “obstructive jaundice (OJ)”, “cellular immunity”, “preoperative biliary drainage”, “selective biliary drainage”, “distal and proximal bile duct block”, “complications”. Randomized clinical trials and meta-analyzes, opinions of reputable specialists in hepatopancreatobiliary surgery and our own experimental and clinical studies were foreground. The analysis showed that preoperative biliary drainage is not a safe procedure and results an increased number of complications. Absolute indications for preoperative biliary drainage are cholangitis, need for neoadjuvant chemotherapy, increased risk of radical surgery and unresectable tumor. Future liver remnant volume should be considered in patients with portal cholangiocarcinoma followed by proximal block to determine indications for preoperative biliary drainage.
The effect chemical treatment of the substrate cadmium telluride on the quality of epitaxial structures
Authors: Paramonov V. V. , Novikova O. V. , Kosushkin V. G.
Published: June 2019

The etching of wafers of cadmium telluride in aqueous and nonaqueous solutions before the epitaxial process of building structures CdxHg1-xTe and its influence on the surface quality of epitaxial layers. As the etchants investigated 2—20 % solution of bromine in isobutyl alcohol, 5 % solution of bromine in methanol, dimethylsulfoxide, ethylene glycol, solutions of bromine in hydrobromic acid and mixed with glycerin, a saturated solution of potassium dichromate in sulfuric acid. The speed of etching was varied from 0.2 to 9 µm/min. Polishing Set nature of the etching substrate of cadmium telluride in 5 % solution of bromine in i-butanol, the dissolution process is diffusion in nature and is limited by the mass transfer of the reactants in the temperature range of 10—60 °C, depending on the concentration of bromine and the viscosity of the solution. Studied the morphology and surface finish of epitaxial layers of CdxHg1-xTe, depending on the method of etching the original substrate. Found the optimal compositions of etchants for precipitaciones processing of obtaining structures with a height of asperities of the surface at 0.1 atm.
Non-local dispersion and ultrasonic tunneling in concentrationally graded solids
Authors: Shvartsburg A. B. , Malinkovich M. D. , Kislyuk A. M.
Published: June 2019

The non-local dispersion of longitudinal ultrasonic waves is shown to appear in the heterogeneous solids due to continuous spatial distributions of their density and/or elasticity (gradient solids). This dispersion gives rise to the diversity of ultrasonic transmittance spectra, including the broadband total reflectance plateau, total transmission and tunneling spectral ranges. The ultrasonic wave fields in gradient solids, formed by interference of forward and backward travelling waves as well as by evanescent and antievanescent modes are examined in the framework of exactly solvable models of media with continuously distributed density and elasticity. Examples of transmittance spectra for both metal and semiconductor gradient structures are presented, and the generality of concept of artificial non-local dispersion for gradient composite materials is considered. It should also be noted that the wave equation for acoustic waves in gradient media with a constant elasticity modulus and a certain predetermined density distribution reduces to an equation describing the electromagnetic wave propagation in transparent dielectric media. This formal similarity shows that the concept of nonlocal dispersion is common for both optical and acoustic phenomena, which opens the way to the direct use of physical concepts and exact mathematical solutions, developed for gradient optics, to solve the corresponding acoustic problems.
Böbrek Naklinde Hücresel Tedavilerin Kullanımı
Authors: ŞENOL Özgür , KAYA Egemen , KARAKUŞ Volkan
Published: June 2019

Günümüzde,
tıp, cerrahi alanında görülen gelişmeler ve teknolojik olarak geliştirilen
modern ilaçların kullanımıyla beraber, geçtiğimiz yüzyılda böbrek hastalıkları
da dahil olmak üzere, ölümcül olan birçok hastalık artık tedavi edilebilir
konuma gelmiştir. Böbrek nakli, elde edilen başarılar ile beraber,  hem böbrek hastalıkları için bir tedavi
seçeneği haline gelmiş ve böbrek nakil oranları artış göstermiş, hem de
beklenen yaşam süresi uzamıştır. Böbrek nakli yapılan hastaların cerrahi
sonrası tedavi süreçlerinde immünsüpresif ilaçlar kullanılmaktadır. Yeni
geliştirilmeye çalışılan tedavi seçenekleri ile hem böbrek naklinde elde edilen
başarı oranı arttırılmaya çalışılmakta hem de immünsüpresif ilaçların
kullanımının yol açtığı yan etkilerin giderilmesi amaçlanmaktadır. Hücresel
tedaviler de böbrek naklinde kullanılması için üzerinde çalışılan tedavi
seçeneklerinden bir tanesidir. Regülatör T hücreler, regülatör B hücreler, regülatör
makrofajlar, dendritik hücreler, mezenkimal kök hücreler, organ nakillerinde
kullanılması için araştırma ve deneme yapılan hücre kaynaklarındandır. Deney
hayvanlarında nakil modellerinde yapılan çalışmalarda, hücre tedavileri ile
başarılı sonuçlar alındığı gösterilmiştir. Bu derlemede böbrek naklinde
kullanılan ve de kullanılmaya aday olan hücre tedavileri tartışılmıştır.
Phenol-Chloroform Extraction for dsRNA Purification v1
Authors: Fisher Cera
Published: June 2019

This is the final step in preparing injectable constructs for RNA interference. This protocol starts with a 20 uL T7-polymerase transcription reaction. We use New England Biolab's HiScribe kit. Our template cDNA has been prepared with T7 promoter regions at each 5' end, enabling RNA transcription in both directions. After dsRNA has been extracted, pelleted, and resuspended in pure nuclease-free water, we will melt the strands apart and allow them to reanneal slowly to ensure that we have plenty of properly double-stranded RNA. The protocol is based on the manufacturer's manual for the HiScribe kit, modified with information from the MegaScript T7 RNA transcription kit manual (Ambion).
Nsil1-Msp1 RAD-digest Detailed Protocol v2
Authors: JG Sutherland Ben , E Rycroft Claire , Miller Kristina
Published: June 2019

This protocol comes with no guarantees, and is primarily used for the authors’ purposes. This protocol is an adaptation from the work in the following publications: Mascher M, Wu S, Amand PS, Stein N, Poland J (2013) Application of Genotyping-by-Sequencing on Semiconductor Sequencing Platforms: A Comparison of Genetic and Reference-Based Marker Ordering in Barley. PLoS ONE 8(10): e76925. https://doi.org/10.1371/journal.pone.0076925 Recknagel, H.,Jacobs, A.,Herzyk, P., &Elmer, K. R.(2015).Double‐digest RAD sequencing using ion proton semiconductor platform (ddRADseq‐ion) with nonmodel organisms.Molecular Ecology Resources,15,1316–1329.https://doi.org/10.1111/1755-0998.12406
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE TGT (TEAM GAMES TOURNAMENT) TERHADAP MOTIVASI BELAJAR DAN KEMAMPUAN MOTORIK SISWA ASRAMA KELAS VII
Authors: Sonjaya Azhar Ramadhana
Published: June 2019

ABSTRAK Tujuan dari penelitian ini adalah mengidentifikasi pengaruh model pembelajaran kooperatif tipe TGT dan model pembelajaran konvensional terhadap motivasi belajar dan kemampuan motorik siswa, Metode yang digunakan adalah pretest-posttest control group design dengan menggunakan cara random assignment. Populasi penelitian ini adalah siswa asrama kelas VII Pondok Pesantren PERSIS Tarogong Kabupaten Garut berjumlah 30 siswa dengan menggunakan teknik total sampling dan waktu pelaksanaan penelitian selama 12 kali pertemuan, setiap minggu dilakukan penelitian sebanyak 3 hari. Hasil dari uji penelitian ini menggunakan uji Manova (Multivariate Analisis of Varians) dengan program SPSS seri 16. Berdasarkan hasil uji hipotesis rata-rata motivasi belajar pendidikan jasmani yang diberikan model pembelajaran kooperatif tipe TGT sebesar 14,875 lebih besar dibandingkan rata-rata motivasi belajar siswa yang diberikan model pembelajaran secara konvensional yakni sebesar 5,25. Demikian juga untuk rata-rata kemampuan motorik siswa yang diberikan model pembelajaran kooperatif tipe TGT sebesar 6,681 lebih besar dibandingkan rata-rata kemampuan motorik siswa yang diberikan model pembelajaran konvensional yakni sebesar 4,648. Maka model pembelajarankooperatif tipe TGT lebih baik dibandingkan model pembelajaran konvensional terhadap motivasi belajar dan kemampuan motorik siswa asrama kelas VII di Pondok Pesantren PERSIS Tarogong Kabupaten Garut pada pelajaran pendidikan jasmani.
PENGUKURAN PRAKTIK DASAR LISTRIK MENGGUNAKAN IMPORTANCE–PERFORMANCE (IP) ANALYSIS
Authors: Mulyana Elih
Published: June 2019

Kemampuan praktik dengan hasil yang diharapkan merupakan isu utama untuk meningkatkan proses pembelajaran praktikum. Penelitian ini bertujuan megukur capaian mahasiswa pada praktik dasar listrik. Penilaian kemampuan dasar dalam praktik dan nilai yang diharapkan, dianalisis dengan perhitungan gap yang diadaptasi dengan menggunakan Importance – performance (IP) analysis. Secara implisit masing-masing atribut dimasukan ke dalam kuadran model persamaan struktural IP- analysis orde ke 2. selanjutnya hasil pemetaan setiap parameter tersebut dianalisis sebagai berikut kuadran A: Prioritas utama; kuadran B: pertahankan kerja bagus; kuadran C: prioritas rendah; kuadran A: prioritas berlebih. Hasil penelitian menunjukkan, kinerja mahasiswa tercapai untuk aspek prestasi membaca gambar, memilih komponen, memasang komponen dan prioritas berlebih, mengukur hasil praktik dan menginterpretasikan hasil pengukuran.
PENGEMBANGAN KIT PRAKTIKUM DIFRAKSI DAN INTERFERENSI CAHAYA UNTUK MENINGKATKAN PENGUASAAN KONSEP DAN KEMAMPUAN BERPIKIR KRITIS
Authors: Setiawan Asep , Pursitasari Indarini Dwi , Hardhienata Hendardi
Published: June 2019

This study aims to develop diffraction and light interference practicum kits to improve the mastery of concepts and students' critical thinking skills. The research method begins with needs analysis, design, expert validation, testing to students, and application of practicum kits in learning. The instruments used were expert validation sheets, concept mastery tests and critical thinking skills, observation sheets of teacher and student activities, and student response questionnaires. The results of the study showed the validator's assessment for the content validity aspect and construct validity practicum kit was 91.3%. As well as the N-gain from the initial test and the final test mastery of the concept of 42% (sufficient category) and critical thinking ability by 45% (sufficient category). Inferential statistical test results show that there were significant differences between the initial test scores and the final test of mastery of concepts and critical thinking skills. This result was supported by student response questionnaire after learning with an assessment of 97.3%.
PENINGKATAN KEMAMPUAN MEMECAHKAN MASALAH MATEMATIKA DAN SELF EFFICACY MELALUI PEMBELAJARAN BERBASIS MASALAH
Authors: Krismayanti Rika , Sumarmo Utari , Maya Rippi
Published: June 2019

Penelitian ini bertujuan untuk meningkatkan kemampuan memecahkan masalah matematika dan self efficacy siswa melalui penerapan pembelajaran berbasis masalah. Penelitian dilakukan dengan menggunakan metode eksperimen dengan disain pretes-postes dengan kelompok kontrol. Kemampuan memecahkan masalah matematika (KMMM) dari 51 siswa SMP kelas VIII diukur dengan menggunakan instrumen tes pemecahan masalah matematika. Adapun peningkatan self efficacy siswa dievaluasi dengan menggunakan tes skala self efficacy. Persepsi mahasiswa terhadap pembelajaran berbasis masalah dievaluasi dengan menggunakan angket. Hasil penelitian menemukan bahwa capaian KMMM siswa yang mendapat pembelajaran berbasis masalah lebih tinggi dari pada siswa yang mendapat pembelajaran biasa. Namun tidak terdapat perbedaan nyata self efficacy siswa pada kedua kelas penelitian. Tidak ditemukan keterkaitan antara kemampuan pemecahanan masalah matematik dan self efficacy siswa. Respon positif siswa terhadap pembelajaran menunjukkan bahwa pembelajaran berbasis masalah dapat membantu memotivasi siswa serta meningkatkan KMMM siswa.
CHARACTERISTICS OF KINDEGARTEN STUDENTS’ PERFORMANCE ON MORPHOLOGICAL AWARENESS
Authors: Karunia Nur , Kurniawan Eri
Published: June 2019

The purpose of this study is to describe the characteristic of high-performing and low-performing students based on the morphological awareness test. This research is about the morphological awareness of 5-6-year-old kindergarten students in Bandung. The method used is the descriptive quantitative method, using questionnaires and interview as the data collection instruments. The instruments were given to the parents of 12 kindergarten children who showed high-performance and low-performance. The results showed that the characteristics of high-performing students is that they were from higher SES families (better education, job, and income), and they use Bahasa Indonesia dominantly.
Analysis of the Maturity of Sustainable Project Management in Russian Enterprises in the Transition to the Digital Economy
Authors: Apenko Svetlana N. , Fomina Yulia A.
Published: June 2019

The subject of the study is the method of assessing and analyzing the level of maturity of sustainable project management of Russian enterprises. Having reviewed the scientific literature, the authors proved the tendency of integration between project management and the concept of sustainable development. The analysis of approaches to assessing sustainability indicators showed a lack of consistency, as well as the shift in emphasis to individual indicators and insufficient attention to institutional sustainability indicators. The problem is in the lack of a methodology for quantifying the level of maturity of sustainable project management which could become the basis for monitoring this management. The availability of monitoring is a prerequisite for a successful transition to the digital economy; while data-based management as the result of monitoring can become a platform for optimizing sustainable project management by tracking sustainability indicators. Due to the used methods of analysis of literature and international professional standards, as well as in-depth interviews with top managers of enterprises, the authors substantiated the method of assessing the level of maturity of sustainable project management, the innovation of which is the inclusion of the module of institutional indicators of sustainability and integrated quantitative assessment of economic, social and environmental indicators of sustainable project management. The technique was approbated through survey at 19 Omsk enterprises and the analysis of survey results is given in the article. A group of enterprises with high and above average maturity levels of sustainable project management was identified. The indicators of the institutional evaluation module demonstrating good potential for further development of sustainable project management are fixed. The influence of the transition to the digital economy on the increasing demand for monitoring the sustainability of project management is examined. The results can be used to optimize the processes of sustainable project management and to further improvement of the methodology of evaluation of this management in the context of the transition to digitalization of the economy and management
Teachers' Perceptions about the Etiology of Intelligence and Learning Difficulties
Authors: Antonelli-Ponti Mayra , Crosswaite Madeline
Published: June 2019

The etiology of intelligence and learning difficulties are interpreted and perceived in different ways within society. The present study aims to explore the perceptions of a sample of n=501 Brazilian teachers regarding genetic and environmental influences on intelligence and learning difficulties. Using numerical scales, it was observed that importance was ascribed by teachers to genetic and environmental influences across both the intelligence and learning difficulties domains. A multiple choice items test revealed differences on the perceptions of teachers according to gender, age, schooling, area of knowledge, income, years of experience, knowledge of genetics, and having studied genetics. Responses favouring genetic explanations were associated with certain demographic factors while the perception that only environment affects the various domains was not associated with any specific demographics.
Motivational Beliefs Specific to Business Studies Subfields: Interrelations, Antecedents, and Change in the Introductory Study Phase
Authors: Gorges Julia
Published: June 2019

In higher education, self-concepts of ability (SCA) and intrinsic task values (ITV) are key determinants of students’ choice of study program and dropout. Both constructs are multidimensional (i.e., specific to curricular learning content) and hierarchically structured (i.e., aggregate into one or more higher-order factors), which is often neglected in higher education research. Therefore, the present study investigated German business studies students’ (N = 375; age: M (SD) = 21.8 (5.51); 59% female) SCAs and ITVs at the level of subfields. Longitudinal data collected at the transition into higher education (t1) and toward the end of the first semester (t2) gave insight into (changes in) interrelations and antecedents of subfield-specific SCAs and ITVs during the introductory study phase, when students likely had to review their hitherto anticipated motivational beliefs. Results from confirmatory factor analyses and structural equation modeling revealed that interrelations of SCAs and ITVs decrease over time. SCAs correlate increasingly strongly within a mathematical and a verbal domain compared to cross-domain correlations. Accordingly, mathematics, but not German SCA, from high school predicts all subfield-specific SCAs at t1, but only mathematical subfield SCAs at t2. The pattern of results for ITVs is less systematic:  Mathematics ITV consistently predicted both mathematical subfield ITVs, whereas German ITV predicted law ITV only at t1. Curricular and practical implications of the subfield-specific formation of motivational beliefs at the transition into higher education are discussed.
Procesos de clima frío en el extremo NE peninsular de la Cordillera Bética. Revisión y síntesis de investigaciones previas
Authors: Marco Molina Juan Antonio , Giménez Font Pablo , Padilla Blanco María Ascensión
Published: June 2019

En las últimas dos décadas, los estudios sobre procesos de clima frío se han multiplicado en la Península Ibérica, en un contexto de creciente interés internacional en la dinámica de los ambientes glaciares y periglaciares. Dicho interés ha promovido la formación y consolidación de grupos de investigación en torno a la International Permafrost Association, con un significativo aumento de investigaciones que incluyen artículos de síntesis sobre estos fenómenos en el ámbito peninsular. El presente trabajo aporta una revisión del estado de la cuestión, sobre los estudios realizados en el extremo NE peninsular de la Cordillera Bética (1973-actualidad). El objetivo de esta aportación es revisar y sintetizar el conocimiento de este espacio montañoso, donde las altitudes por encima de los 1000 m s.n.m. ocupan una superficie de 190 km2. En los resultados destaca la localización de derrubios estratificados, a 800 m s.n.m, y suelos en guirnaldas, a poco más de 1500 m s.n.m. Se resalta la necesidad de continuar con la labor de catalogación e inventario de formas en numerosos macizos que todavía están escasamente estudiados, así como la de aplicar procedimientos de datación.
Foreword by the Editor
Authors: Tolstykh N.N.
Published: June 2019

The problem of generations has grown in popularity and is widely discussed on various media platforms, while remaining, at the same time, relatively under-researched.
Generation as a social-psychological research object: playing at home or an away match?
Authors: Rikel A.M.
Published: June 2019

The article examines the methodological difficulties associated with studying of the generation category in social psychology. The history of studying the problems of generations and intergenerational conflicts in psychology and humanitarian disciplines is briefly analyzed, the conclusion is drawn about the vastness of both the theoretical concept and the blurriness of the methods of the empirical operationalization of the generation. Theoretically close constructs are given, allowing one to consider generational problems within the framework of other conceptual frameworks. Existing models and theories of generations, including popular science, are considered, their critical analysis is carried out. Some theoretical decisions are proposed that allow one to reduce the problems associated with the operationalization and study of the generation in social psychology.
The problem of generation in a foster family as a special small social group
Authors: Makhnach A.V.
Published: June 2019

The peculiarities of changes in the structure of a foster family after the child adoption, related to the restructuring of borders, rules, norms that exist in the family before adoption are discussed. The structural features of a foster family are described, which make it possible to analyze the characteristics of the family that are important for its resilience. Taking into account the generation factor, the characteristics of the family system in the dyad grandmother (grandfather) — grandson (granddaughter) and the specifics of the developmental stages of a foster family are analyzed. Intergenerational inverted structure can be quite hard, as it seems to all family members. It justifies the assumption that the intergenerational coalition can manifest itself in the gradual forming of the child’s relationship with foster parents and the latent / open conflict between the child and the foster grandmother / grandfather. The possibility of a hidden coalition between the foster mother and the child and pushing the foster father out of this coalition is shown. It is concluded that the study of family composition on the basis of kinship intergenerational relations between foster parents and foster children is not given enough attention, the topic remains poorly investigated, despite its relevance.
Conference commemorating M.Yu. Kondratyev: continuity and innovation
Authors: Krushelnitskaya O.B.
Published: June 2019

The article is a brief report on the 4th Annual Scientific and Practical Conference commemorating M.Yu. Kondratyev “Social psychology: questions of theory and practice”. The main events and results of the conference are described. Designated promising areas of modern social psychology.
COMPOSITE CORONARY ARTERY BYPASS GRAFTING
Authors: Frolov A. V. , Kozirin K. A.
Published: June 2019

The article presents the historical insights into composite coronary artery bypass grafting, current concepts and its different variants. A smaller number of manipulations on the aorta during the procedure has been proved to reduce significantly the risk of ischemic stroke. However, it requires off-pump technology, which is still controversial despite all its advantages. No doubt, composite or compound bypass grafting allows performing myocardial revascularization even if there is a lack of conduits. A particular concern has been paid to the connection between the arterial and venous conduits, therefore emphasizing the relevance of composite coronary artery bypass grafting.
A COMPREHENSIVE APPROACH TO THE MANAGEMENT OF CRITICALLY ILL
Authors: Grigoryev E. V. , Mikhailova A. A. , Shukevich D. L. , Plotnikov G. P. , Radivilko A. S. , Matveeva V. G.
Published: June 2019

The study of long-term treatment outcomes of patients in the intensive care unit (ICU) is necessary for the rapid recovery of a critically ill patient. Training of ICU staff in basic rehabilitation techniques for early rehabilitation and resocialization of patients allows promoting improvements in postresuscitation immunosuppression, polyneuropathy, polymyopathy, and cognitive dysfunction. The introduction of rehabilitation in the ICU enables avoiding the concept of syndrome-treatment of critically ill patients, solving the problem of “a chronic ICU patient”, reducing the number of complications of the underlying disease and chronic pathologies associated with the patient's critical condition. The algorithms for the recovery of critically ill patients are proposed to be introduced from the first day of the hospitalization, when the first pathophysiological recovery patterns begin to form. The role of resocialization in the framework of this approach to the rehabilitation of critically ill patients, the “open ICU” model and deontological aspects of the communication between medical staff and an ICU patient are put forward. The prevention of delirium after cardiac arrest contributes greatly to the further prevention of post-resuscitation cognitive dysfunction, decreases depression and prevents oversedation. A new phenotype of a chronic critically ill patient, the “patient after a critical condition,” is introduced with the discussion of the pathophysiological patterns involved in its formation. The relevance of this review is confirmed by the growing interest to the integration between ICU staff and patient`s family, thus emerging the role of social aspect of the rehabilitation in critically ill patients. The novelty of this research is imposed by advanced approaches to the early rehabilitation of ICU survivors which are currently neglected from the routine ICU practice.
VITAMIN D DEFICIENCY IN PATIENTS WITH ACUTE CORONARY SYNDROME
Authors: Bogachev R. S. , Mikhailova L. V. , Shytova E. S. , Mordvincev V. V. , Ankudovich V. , Dobrynina U. A. , Kozel A. Y. , Gazatova N. D.
Published: June 2019

Aim. To assess vitamin D level in patients with acute coronary syndrome and to determine the relationships of vitamin D level with specific patterns of cardiovascular disease in this group of patients.

Methods. 50 patients (35 (70%) males and 15 (30%) females) urgently admitted to the emergency cardiology department of Kaliningrad Regional Hospital were enrolled in the cross-sectional observational study. Patients with diabetes mellitus, autoimmune diseases and cancer were excluded from the study. The mean age of patients was 60 (55; 66) years. Cardiovascular risk factors (obesity, smoking, physical activity, alcohol consumption, genetic predisposition) were assessed in all patients. Total serum cholesterol levels, GFR (CKD-EPI) and troponin levels were measured in all participants. Echocardiography included the measurement of the left ventricular mass index. Coronary angiography with omnipaque contrast was performed in all cases. 25-OH vitamin D was measured with enzyme-linked immunosorbent assay (ELISA).

Results. The majority of patients with acute coronary syndrome had vitamin D deficiency. 3 (6%) patients had severe vitamin D deficiency. The subgroup of patients with marked vitamin D deficiency (n = 39) more often had elevated blood pressure probably related to the left ventricular hypertrophy and left atrial enlargement. Left ventricular systolic dysfunction and occlusive coronary artery disease were more common in patients with lower vitamin D levels. Statistically significant correlations had not been found between vitamin D levels and cardiovascular risk factors as well as laboratory data.

Conclusion. Vitamin D level below normal range was detected in the vast majority of patients with acute coronary syndrome, of them 6 % of patients had critically low vitamin D levels.
DIAGNOSIS OF VENOUS ISCHEMIC STROKE. PART I (CLINICAL POLYMORPHISM). A REVIEW ARTICLE
Authors: Semenov S. E. , Moldavskaia I. V. , Yurkevich E. A. , Shatokhina M. G. , Semenov A. S.
Published: June 2019

Venous stroke being “relatively unknown cerebrovascular disease” occurs in 0.55% of all strokes. Specific diagnostic concerns to venous stroke and the expansion of the volume of radiologic examinations from routinely used non-contrast CT to angiographic and perfusion CT- and MRI, diffusion MRI allowed us to increase the number of diagnosed and verified venous ischemic stroke from 0.4% of all strokes treated in our center to 2.4%, resulting in a 6-fold increase within the 5-year period. Symptoms of cerebral venous sinus thrombosis depend on the size and the growth rate of thrombus. In addition, focal neurological symptoms are diverse and largely dependent on thrombus localization and safety of collateral blood flow, as well as patients’ age and severity of cerebral edema. Cerebral symptoms are nonspecific and may occur in varying degrees of severity related to the localization of the pathological process. The routinely used assessment scales such as the National Institutes of Health Stroke Scale (NIHSS), Bartel Index, Rankin Scale do not reliably identify this type of acute ischemic stroke. The leading symptom is headache with the mean visual analogue scale of 7.3±1.6. The tendency towards a less pronounced neurologic deficit at admission and mild disability status at discharge have been found among patients with venous stroke. The clinical course of venous stroke mostly demonstrated a tendency towards rapid regression of focal symptomatology and neurological deficit in comparison with arterial ischemic stroke.
PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUGS FOR OPTIMIZING BLOOD PRESSURE IN YOUNG ADULTS
Authors: Kovrigin I. S. , Petrova M. M. , Kaskaeva D. S. , Romanova I. V.
Published: June 2019

Aim. To evaluate the pharmacoeconomic analysis of three antihypertensive drugs routinely used to optimize blood pressure in young adults.

Methods. 250 patients were recruited to the study and subdivided into three groups: Group 1 patients (n = 131) received monotherapy with angiotensin-converting enzyme inhibitor, ramipril; Group 2 and 3 patients (n = 119) received combination therapy with perindopril + amlodipine and ramipril + amlodipine.

Results. The group of patients receiving ramipril had the average daily dose of 10 mg, patients taking egipres received 5/10 mg daily, and patients receiving prestans took 5/5 mg daily. Thus, the cost of treatment with ramipril at the dose optimally reducing blood pressure remained the same, while the cost of treatment with prestans decreased up to 37400.00 RUB, and egipres up to 45218.00 RUB. 4.76% of patients who received these antihypertensive medicines experienced side effects, namely cough, dizziness, a sharp decrease in blood pressure, allergic dermatitis, nausea. The least rate of side effects occurred in patients who received perindopril, whereas the highest was recorded in the group of patients receiving ramipril (3.5% vs. 6.5%, respectively).

Conclusion. No significant differences found in the antihypertensive effects between three groups of drugs (ramipril, prestans, egipres). All three medicines included in this study effectively reduced blood pressure. However, prestans was associated with the least rate of side effects. Most side effects were short-term and of mild to moderate severity.
Koalisyon Hükümetlerinde Basın Özgürlüğü: Doğru Yol Partisi ve Sosyal Demokrat Halkçı Parti/Cumhuriyet Halk Partisi Örneği (1991-1996)
Authors: BASMACI Göksel
Published: June 2019

1991-1996 yılları arasındaki DYP-SHP/CHP koalisyon hükümeti, Türkiye’nin en uzun süre yönetimde kalan koalisyonu olmuştur. Bu süreçte, hükümeti oluşturan partilerde ve liderlerde çeşitli değişiklikler yaşansa da birlikteliğin sürdürüldüğü görülmüştür. Farklı ideolojilerdeki partilerin anlaşması sonucunda kurulan ortaklık döneminde, ekonomi ve hukuk başta olmak üzere, birçok alanda köklü dönüşümler yaşanmıştır. Öte yandan ülke genelinde, terör olayları artmış ve birçok kişi öldürülmüştür. Söz konusu gelişmelerin yanı sıra bu hükümet döneminde, basın alanında da önemli değişikliklerin ve sorunların yaşandığı görülmüştür. Bu doğrultuda, çalışma kapsamında, DYP-SHP/CHP koalisyon hükümeti yönetiminde, basına dair yapılan yasal düzenlemeler ve basının genel durumu incelenmiştir. DYP-SHP/CHP koalisyon hükümetinde, basının özgür olup olmadığını saptamak çalışmanın sorunsalı olarak belirlenmiştir. Bu bağlamda, basın özgürlüğünün ve çıkarılan yasaların ne yönde şekillendiğini ortaya koymak ise çalışmanın amacını oluşturmaktadır. Çalışma, DYP-SHP/CHP koalisyonu dönemindeki basının durumunu yansıtması nedeniyle önem taşımaktadır. Bu doğrultuda yürütülen çalışmada, betimleme yöntemi kullanılmış ve alana ilişkin yazılı kaynaklardan yararlanılmıştır. Sonuç olarak, DYP-SHP/CHP koalisyon hükümeti döneminde basına yönelik yoğun baskı ve denetim uygulandığı saptanmış ve basın özgürlüğünün açık bir şekilde kısıtlandığı görülmüştür.
Feeling in Responding Advertising Exposure on YouTube: The Moderation Influence of Online Experience
Authors: RAHARJO Tri Weda
Published: June 2019

The use of YouTube as a medium of social networking to promote the products proved to be quite effective, yet sometimes it can cause disruption to the users. It is due to the advertisement has interrupted the streaming activity, causing annoyance and displeasure followed by avoidance. Regarding with the problem, this study examined the feelings while response to ad impressions on YouTube. The population of the study is including the YouTube users in Indonesia. Questionnaires used for collecting data which is involving 105 samples of 263 samples that had been spread on colleges and government offices in Surabaya. From the results of this study, it can be concluded that: (1) ad intrusiveness significantly affect ad irritation; (2) online experience does not significantly provide impact in weakening the relation among ad intrusiveness and ad irritation; (3) online experience significantly impact on weakening the relation among ad intrusiveness and ad avoidance; (4) ad intrusiveness significantly affect ad avoidance; (5) ad irritation significantly affect ad avoidance; (6) ad avoidance does not significantly affect the attitude toward the brand.
ANÁLISE DA PERTURBAÇÃO ACÚSTICA PRODUZIDA POR MOTOSSERRAS E ROÇADORAS EM DIFERENTES AMBIENTES
Authors: Santos L. M. , Ferraz G. A. e S. , Martins F. B. D. S. , Salvador R. R. , Ferraz P. F. P.
Published: June 2019

O setor florestal sofreu grande avanço com a introdução das motosserras e roçadoras em seu processo. Apresentando um custo relativamente baixo e facilidade de operação, as máquinas portáteis tornaram-se essenciais. O ruído está presente na rotina diária dos seres humanos e, esse complexo de sons, pode causar sensações de desconforto. O presente trabalho teve como objetivo analisar o nível de ruídos emitido por três modelos de motosserras e dois modelos de roçadoras. O experimento foi realizado em três ambientes: dentro de uma oficina, dentro de uma cabine de testes e no campo (ambiente de trabalho), testando-se três motosserras diferentes e duas roçadoras a combustão e uma à bateria, sendo operadas em duas rotações (baixa e alta). Para a mensuração do ruído emitido por estas máquinas foi utilizado um decibelímetro. Os dados foram analisados por meio de agrupamento hierárquico aglomerativo. Observou-se que a potência da máquina, a rotação e o ambiente foram preponderantes para o ruído emitido por estas máquinas, além disso, todas as motosserras testadas apresentaram ruídos muito superiores a 85dB (A), preconizados pela norma, quando operados na oficina e em ambiente de trabalho e para as duas rotações testadas. Operadas dentro da cabine de testes, os motosserras apresentaram-se dentro dos padrões da norma, independentemente da rotação. Já a roçadora a combustão apresentou valores superiores a 85dB (A), para as duas rotações avaliadas quando operada em campo aberto, enquanto que a roçadora a bateria apresentou valores superiores a 85dB (A) apenas para alta rotação.
GINÁSTICA LABORAL EM CAVALOS TERAPEUTAS MELHORA A QUALIDADE DO MOVIMENTO TRIDIMENSIONAL DO TROTE
Authors: Oliveira K. , Bocci C. L. , Patini A. F. , Araújo M. S.
Published: June 2019

Objetivou-se determinar se cavalos terapeutas submetidos a ginástica laboral desenvolvem melhor qualidade do movimento tridimensional ao trote, avaliado por meio das variáveis biomecânicas como, cadência, regularidade e simetria. Foram utilizados vinte cavalos terapeutas, mestiços, com idade média de 19±3,5 anos e peso vivo médio de 440±50 kg. Os tratamentos consistiram em um total de cinco grupos experimentais, compostos por grupo controle (sem realização de exercícios) e de quatro grupos testes de cavalos submetidos a ginástica laboral, com frequências semanais crescentes de realização, variando de uma à quatro vezes/semana. A ginástica laboral foi conduzida durante período de três meses. O delineamento utilizado foi inteiramente casualizado, resultando em quatro repetições por tratamento. Foram mensuradas as variáveis biomecânicas, referentes a coordenação do andamento ao trote como, cadência da passada (CAD), regularidade da passada (REG) e simetria da passada (SIM), para determinar a qualidade do movimento tridimensional, por meio do acelerômetro Equimetrix. Foi verificada ausência de efeito significativo para o ganho na CAD ao trote (P>0,05). Contudo, foi observado melhora nos ganhos da REG e SIM (P<0,05), em que os melhores resultados foram encontrados aos cavalos submetidos a ginástica laboral realizada de três à quatro vezes/semana, com valores de 15,4 e 16,0 (/200) para REG e de 14,9 e 20,6 (%) para SIM, respectivamente. Concluiu-se que a realização de ginástica laboral em cavalos terapeutas, a partir de três sessões semanais, melhora o movimento tridimensional do trote, devido ao ganho na regularidade e simetria, mantendo-se a mesma cadência de passada.
ESTOQUES DE CARBONO E RETENÇÃO HÍDRICA EM BIOMASSA DE GRAMÍNEAS NO AGRESTE DA PARAÍBA
Authors: Da Silva P. L. F. , De Oliveira F. P. , Pereira W. E. , Borba J. O. de M. , Tavares D. D. , Santos T. E. D. , Martins A. F.
Published: June 2019

O sistema de manejo, quando adotado de forma incorreta pode ocasionar à degradação física, química e biológica do solo, principalmente na ausência de cobertura vegetal. A escolha da gramínea é parte fundamental nos sitemas de produção, principalmente quanto a produção de matéria seca e a deposição de carbono ao solo, favorecendo a recuperação de ambientes degradados. Sendo assim, objetivou-se com este trabalho avaliar o estoque de carbono e a retenção hídrica em biomassa de gramíneas cultivadas no agreste da Paraíba. O experimento foi instalado em área experimental do Centro de Ciências Agrárias da Universidade Federal da Paraíba, Areia (PB) (6°58’12’’S; 35°41’15’’W). O delineamento foi de blocos casualisados composto pelos seguintes tratamentos T1 - Brachiaria decumbens Stapf., T2 - Brachiaria brizantha, T3 - Brachiaria humidicola (Rendle) Schweick vr., T4 - Brachiaria brizantha cv. MG5 - Vitória e T5 - Sem cobertura vegetal. As variáveis analisadas foram: carbono orgânico total, estoque de carbono, produção de matéria seca e reteção hídrica na matéria seca. De acordo com os resultados, a Brachiaria brizantha foi superior na produção de matéria seca e na capacidade de retenção hídrica. O carbono orgânico total e o estoque de carbono não variaram entre os tratamentos avaliados.