bluuebunny/crossref_metadata_2025 huggingface dataset:
New Border for Mass Graves of the 1930–1950s Repressed People in the Area of the Memorial Complex on the 12th Kilometer of the Moscow Highway in Ekaterinburg
Authors:   Museum of History of Ekaterinburg (Russia, Ekaterinburg), Pushkarev Igor , Maslennikov Evgeniy ,   Museum of History of Ekaterinburg (Russia, Ekaterinburg), Petrovskaya Kristina ,   Museum of History of Ekaterinburg (Russia, Ekaterinburg), Kirova Maria ,   Museum of History of Ekaterinburg (Russia, Ekaterinburg), Karacharov Ivan ,   Museum of History of Ekaterinburg (Russia, Ekaterinburg)
Published: January 2024

The article presents the results of archaeological search work undertaken in 2017–2022 to clarify the boundaries of the distribution of mass graves of the 1930–1950s repressed people in the area of the Memorial complex on the 12th kilometer of the Ekaterinburg — Perm motorway (Moscow highway). The functional purpose of the site was established in 1990 during a partial exhumation by the prosecutor’s office. The question of the distribution of human burials was raised during additional engineering-geological and geophysical surveys in 1992, carried out by the UralTISIZ enterprise. However, no further work was undertaken for a quarter of a century. The question of the boundaries of the necropolis remained open. Moreover, during the construction of the Memorial Complex to the Victims of Political Repression in 1996 and during its subsequent reconstruction, part of the site with mass graves entered the development zone without proper research and exhumation procedures. During the 2017–2022 research work, for the first time the border of the NKVD testing ground has been established, within which death sentences were carried out and the bodies of the repressed were buried. The boundaries of the necropolis — the so-called Southern zone of mass graves — were determined. The mass graves of the repressed, untouched as a result of subsequent anthropogenic impact, were counted and described. Methodological approaches to further examination of the NKVD test site of the 1930-1950s on the 12th kilometer of the Ekaterinburg — Perm motorway (Moscow highway) were formed.
The Archaeological Heritage of the Municipal Formation of the City of Ekaterinburg: A General Overview, the 2023 Inventory Results
Authors:   Scientific and Production Center for the Protection and Use of Historical and Cultural Monuments of the Sverdlovsk Region (Russia, Ekaterinburg), Fedorova Darya
Published: January 2024

There are almost all types of archaeological monuments (settlements, burial grounds, pictograms, ancient production sites) on the territory of the municipal formation of the city of Ekaterinburg, most of them are represented by settlements located along the banks of watercourses and lakes. The dating of the sites covers a wide range from the Mesolithic to the Late Iron Age. At the same time, no more than 10 % of the sites have been explored. The number of archaeological sites in the Ekaterinburg municipality as of 2023 totals 124 objects (according to the State Security authorities). At 66 objects of cultural (archaeological) heritage, the boundaries of the distribution of the cultural layer are defined, and information about them is included in the Unified Register of Objects of Cultural Heritage of Russia. The remaining sites are in the status of identified objects of cultural (archaeological) heritage. They have yet to be added to the register. This article presents a general overview and characteristics of objects of cultural (archaeological) heritage located within the modern boundaries of the municipal formation of the city of Ekaterinburg. It also considers the results of work to determine the boundaries of the spread of the cultural layer on objects of cultural (archaeological) heritage from 2013 to 2022, necessary for entering information about sites in the state cadaster of real estate, methodology and prospects of work in this direction, as well as the need to define the boundaries of all scientifically significant archaeological heritage sites on the territory of Ekaterinburg.
Elevating Efficiency: Designing an Integrated E-commerce Platform for Atlanta Sport Store Based on Yii Framework
Authors: Eltiana Nia Irma , Saputra Hadi Kurnia
Published: January 2024

E-commerce has become a dominant trend in buying and selling transactions; however, the Atlanta Sport Store still relies on a manual approach to managing data, marketing, product sales, and generating sales reports. To address this challenge, we propose an innovative e-commerce platform design for the Atlanta Sport Store. The development methodology involved the waterfall method and Unified Modeling Language (UML) modeling. The programming stack includes PHP as the programming language, MySQL as the database management system (DBMS), and XAMPP as the web server, with coding performed through browsers such as Google Chrome. The primary objective of this design is to create an effective e-commerce site, facilitating customers to find information and make product purchase transactions while simplifying store management activities. This e-commerce design not only addresses online sales needs but also optimizes inventory management, transaction reporting, and financial reporting for store owners. This study makes a significant contribution to optimizing business operations through the implementation of an integrated e-commerce solution, opening up opportunities for increased efficiency and competitiveness in the retail sector.
Customer Requirements on Digital Application in Energy Sectors for B2B Customers (a Part of Quality Function Deployment Analysis on My Pertamina for Business)
Authors: Hendi Prastiyo Rama , Lahindah Laura
Published: January 2024

This study is willing to reveal what are the B2B customers requirement for My Pertamina for Business digital application that they have been using. They are also leaded to evaluate the application performance and reveal what are the resistances in using the application. Literature review and interview are conducted. Seven respondents are involved in the study. They come from three different customer clusters, that are aviation, retail and industrial and marine. The results reveal that customer requirements of B2B customer from digital application in energy sectors are 1) price Simulation, 2) ordering product to create sales order, 3) monitoring tax invoice, 4) monitoring withholding tax slip, 5) the relevance of the displayed energy product to the customer needs, 6) providing many function in one application, 7) connected to direct debit of bank system, 8) connected to other digital platform, 9) forecasting the fuel price, 10) monitoring invoices, 11) energy related news portal and 12) contact center to buy other energy products; 13) reward and discount; and 14) playing entertainment platform such as online game and podcast. Overall performance of the application satisfy the customers but point 7,8,9,10,11,12 and 14 of customer requirements are not fulfilled yet. Dealing with the customer resistance in using the application are slow response of customer complain handling, inaccurate information related to drum stock in the application and in the aviation fuel terminal, and less updated of monitoring Credit/Debit Reversal notes
Development of Digital Teaching Materials to Improve Students' Understanding of Concepts in Physics Subjects
Authors: Juliarti Endasyari , Medriati Rosane , Risdianto Eko
Published: January 2024

The results of interviews with several students and show that there are still many students who have difficulty in understanding concepts in dynamic fluids. Therefore, researchers conduct research that aims to develop digital teaching materials, namely e-modules using the Canva application on the subject of dynamic fluids. This research was carried out using the Research & Development method. The design validity stage involves 3 subjects (two expert judges and one practitioner) involved to assess the feasibility of the material, the design of e-modules, the feasibility of Indonesian language and the feasibility of good and correct media. Feasibility assessment by experts using validation sheets. The trial phase involved 102 students from three schools, namely SMAN 4 Kota Bengkulu, SMAN 5 Kota Bengkulu, and SMAN 9 Kota Bengkulu. Assessment of the attractiveness of the e-module using descriptive analysis assisted by Microsoft Office Excel 2007. The results showed that the feasibility score by the three experts with an average percentage in the content aspect was 92.70%, in the presentation aspect of 91.67%, in the aspect of 98.33, in the media aspect of 97.91%. The response of students with an average percentage of SMAN 4 Bengkulu City 82.22% is in the very good category, SMAN 5 Bengkulu City with an average percentage of 85.01% is in the very good category, SMAN 7 Bengkulu City with an average percentage of 89.65% is in the very good category. So it can be concluded that the e-module using the Canva application produced in this study is considered suitable for use in dynamic fluid learning.
Impression Management in Building Personal Branding by Bengkulu Influencers Through the Reels Feature on Instagram
Authors: Elvina Messy , Gushevinalti Gushevinalti , Widiastuti Wahyu
Published: January 2024

Personal Branding merupakan suatu proses yang dilakukan untuk menunjukkan serta mempertahankan kesan positif tentang diri sendiri berdasarkan ciri khas tertentu kepada orang lain. Personal branding yang dibangun oleh Influencer Instagram Bengkulu diwujudkan dengan melakukan pengelolaan kesan melalui akun Instagram milik masing-masing Influencer Bengkulu. Tujuan penelitian ini adalah untuk mengetahui bagaimana pengelolaan kesan dalam membangun personal branding oleh influencer melalui fitur reels di Instagram. Jenis penelitian yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi, serta mencari referensi melalui buku, jurnal, skripsi dan artikel yang berhubungan dengan penelitian. Penelitian ini juga menggunakan teknik analisis data melalui pengumpulan data, reduksi data, display data, dan verifikasi serta penarikan kesimpulan. Informan penelitian ini diperoleh dengan menggunakan teknik purposive sampling. Teori yang digunakan dalam penelitian ini adalah teori pengelolaan kesan (impression management theory) dengan berakar dari dua cakupan yang terdiri dari presentasi diri dan pengelolaan identitas sosial. Hasil penelitian menunjukkan bahwa para Influencer Bengkulu melakukan diferensiasi guna membangun personal branding dengan mengunggah konten video dengan harapan umpan balik dari pengikut. Kemudian, kategori kelompok rata-rata usia remaja dan dewasa menjadi sasaran dalam mendapatkan keuntungan dari personal branding yang dibangun.
La actuación de los profesionales ante el Covid-19 en Establecimientos de Larga Estadía para Adultos Mayores
Authors: Gomes Nildete Pereira , Oliveira Emanuela Santos , De Oliveira Lélia Mendes Sobrinho , Menezes Tania Maria de Oliva , Freitas Adriana Valéria da Silva , Do Amaral Juliana Bezerra
Published: January 2024

Introducción. La pandemia del nuevo Coronavirus es una enfermedad con alta transmisibilidad y en el caso de las Instituciones de Larga Estadía para Ancianos, el riesgo de contaminación es grande, pues los ancianos presentan mayor vulnerabilidad debido a algunas comorbilidades. Objetivo principal. Relatar sobre la actuación de la monitorización remota de los profesionales sanitarios en la lucha contra el Coronavirus en un Establecimiento de Larga Estadía para Adultos Mayores. Metodología. Informe de la experiencia vivida por los profesionales de la salud durante la actuación en el monitoreo remoto junto a los establecimientos de larga estadía para adultos mayores en la lucha contra el Coronavirus en Salvador, de abril a diciembre de 2020. Resultado principal. Se observó que las orientaciones, brindadas de forma remota, ayudarían a los cuidadores a brindar una atención segura y de calidad a la idónea, adquiriendo así conocimientos específicos sobre cómo prevenir y reducir los riesgos de contaminación y transmisión del nuevo coronavirus. Conclusión principal. La realización del monitoreo fue relevante en el control del Covid-19, resaltando la importancia de la participación a distancia del profesional de salud, en especial de la enfermera, en la gestión de las acciones de cuidado de los ancianos institucionalizados.
Liderazgo de enfermería en el desarrollo de políticas intersectoriales de salud pública
Authors: Vergara León María Pamela
Published: January 2024

La toma de decisiones en políticas de salud pública implican la participación de distintos colectivos a nivel local, estatal y nacional capaces de detectar los problemas de salud que pueden afectar a la población. Sin embargo, el sector de salud por sí solo no puede dar solución a los determinantes sociales de salud que, en su mayoría, son los responsables del bienestar poblacional. En este sentido, el presente artículo trata de identificar los determinantes que afectan la salud a nivel intersectorial: condiciones de vida, desigualdades sociales, desarrollo económico e impacto ambiental. Para afrontarlos, se destaca el papel que podrían tener las enfermeras en la formulación y desarrollo de políticas desde una perspectiva holística, desde la acción intersectorial centradas en salud.
Reflexiones en torno a los retos del sistema de salud colombiano
Authors: Rosero Medina Diego Fernando
Published: January 2024

El sistema de salud colombiano, establecido con la ley 100 de 1993 ha sido reformado a lo largo de su existencia; de estas reformas se destaca la ley estatutaria 1751 de 2015, en la cual se establece la salud como derecho fundamental y se enruta hacia la equidad. La firma de esta ley llevó a la implementación de estrategias centrales y operativización a través de la Política de Atención Integral en Salud (PAIS). Este modelo de salud ha presentado problemáticas en el país como la mercantilización de la salud, liquidación de administradoras de planes de beneficios, crisis financiera de hospitales y limitación del acceso y equidad de la población. En este sentido, el presente texto se propone reflexionar sobre los aspectos estructurales necesarios en el sistema de salud colombiano para la garantía de la salud como derecho fundamental. Resultados: Para garantizar la salud como derecho fundamental es necesaria la implementación de acciones centradas en la promoción de la salud, reconocer la influencia del conflicto armado, cambiar el enfoque de cobertura por acceso al sistema de salud, eliminar intermediación y burocracia, fortalecer las IPS, vigilancia pública de los recursos y cumplimiento de la normatividad vigente. Conclusiones: el sistema de salud colombiano pese a que ha sido uno de los modelos mejor valorados a nivel mundial, presenta problemas que afectan el acceso y calidad de la atención, por lo que requiere modificar aspectos estructurales e incluir elementos no contemplados en la PAIS del actual sistema.
Evolution of Maskless Digital Lithography: Game changer for Advanced Semiconductor Packaging
Authors: Aggarwal Ashwini K
Published: January 2024

Lithography is a fundamental process in semiconductor chip manufacturing, patterning the chip design onto the photoresist coated wafer substrate before it is further processed for creating the device architectures. At one end, cutting EUV lithography is shaping the 3-5nm devices with masks and advanced OPC (optical proximity correction algorithms), and at the other end, newer maskless lithography technologies are shaping patterning at 2micron (predicted to touch 500nm) for other emerging applications in micro-electronics with new commercial propositions and actualization TAT. This paper gives a comparative overview of these patterning technologies and their potent applications in the semiconductor industry.
Identifikasi Jenis dan Kelimpahan Mikroplastik Pada Perairan di Sulawesi Tengah
Authors: Safitri Talitha Aulia Nadifah
Published: January 2024

Mikroplastik merupakan partikel terkecil dari plastik yang memiliki ukuran >5 mm. Mikroplastik telah masuk mengontaminasi lingkungan perairan di Indonesia termasuk di wilayah perairan Sulawesi Tengah. Penelitian ini bertujuan untuk mengetahui kelimpahan dan jenis mikroplastik di perairan Sulawesi tengah dengan metode purposive random sampling. Sampel diambil pada 3 stasiun dengan 5 titik lokasi pengambilan sampel. Identifikasi mikroplastik ini menggunakan mikroskop stereo dengan perbesaran 40×dan kertas milimeter. Jenis mikroplastik yang ditemukan di titik yang telah ditentukan adalah fiber, filamen, fragmen, pellet dan foam. Kelimpahan mikroplastik tertinggi secara keseluruhan didominasi oleh jenis fragmen sebesar 2,21 partikel/L sedangkan yang terkecil adalah jenis foam sebesar 0,001 partikel/L.
Microprudential Indicators of Financial System Stability: An AHP Approach
Authors: Rani Lina Nugraha , Rusydiana Aam Slamet , Hasib Fatin Fadhilah
Published: January 2024

In general there are two indicators of financial system stability, namely microprudential and macroprudential. Among macroprudential indicators are economic growth, balance of payments, inflation rate, interest and exchange rates, crisis contagion effect, and many others. Different from the previous researches concerning financial system stability measurement, this research will use the financial and banking practitioners' perspective regarding the leading indicator in measuring financial system stability so that we can presumably determine the real leading financial stability indicator for the current situation using Analytic Hierarchy Process (AHP) method. This study will look at the indicator of financial system stability from a microprudential perspective in Indonesia. The results show that based on the results of interviews with experts/banking practitioners, the 3 (three) most important aspects are Capital & Asset (0.187), Profitability (0.186) and Asset Quality (0.177). Important indicators of financial system stability from the next microprudential aspect are Liquidity (0.176), Market-based Indicators (0.139) and finally Risk Sensitivity (0.136). The Macroprudential Policy and microprudentials issued by Bank Indonesia as the central bank that has full authority, play an important role in maintaining Financial System Stability (SSK) in Indonesia.
Developing Halal Industry in Indonesia using Interpretive Structural Modeling (ISM)
Authors: Rusydiana Aam Slamet , Mahsyar Nun Maziyyah
Published: January 2024

Halal industry has become a popular object and the latest trends in the world of international business. Not only in Indonesia but also Malaysia, Thailand even Europe began to glance at the potential and opportunities for halal industry. The phenomenon that began to develop halal industry in recent years is quite the attention of businesses and consumers themselves. Labeling "halal" or "sharia" on a product, not again become a form of obligation or obedience to a Muslim but has become the strength of a strong market, which not only as a guarantee of the products that are allowed for a Muslim but also a symbol of the global for quality assurance and a lifestyle choice. In previous studies, many researchers were interested in examining issues about the potential of halal industry, while very few researchers discuss the problems of the development of halal industry in Indonesia. Though research on the obstacles and development strategies of halal industry is needed to accelerate the development of halal industry in Indonesia. Based on this problem, which is taken from the study of literature, previous research and indepth interviews with academicians and practitioners, some issues in the development of the halal industry in Indonesia is divided into five aspects: 1) Policy, 2) Production, 3) Socialization, 4) Infrastructure, and 5) Human Resources.
The contribution of Serbian educators to the affirmation of education, based on national values
Authors: Mušikić-Popović Ilinka
Published: January 2024

The paper analyzes the importance and contribution of Serbian pedagogues to the affirmation of upbringing and education, based on national values. In Serbian pedagogy, several prominent pedagogues, through general reflections on upbringing and education, considered the importance of national education and national values. Accordingly, the paper presents the understanding of Serbian pedagogues in the period from 1918 to 1945, namely: Miloša R. Milošević, Vojislav Bakić, Ljubomir Protić, Sreten Adžić, Jovan Miodragović, Vojislav Mladenović, Miloš B. Janković and Vićentije Rakić. In the indicated historical moment, Serbia was marked by various school reforms, which also affected the content of upbringing and education. The importance of individual pedagogues, who created and acted at that time, is particularly impressive precisely because of the problematization of the idea of the nation and national values in the context of the process of upbringing and education, which is described and shown in more detail in the paper.
Random vector representation of continuous functions and its applications in quantum mechanics
Authors: Li Hong-Xing , Zhou Wei , Mi Hong-Hai
Published: January 2024

The relation between continuous functions and random vectors is revealed in the paper that the main meaning is described as, for any given continuous function, there must be a sequence of probability spaces and a sequence of random vectors where every random vector is defined on one of these probability spaces, such that the sequence of conditional mathematical expectations formed by the random vectors uniformly converges to the continuous function. This is a random vector representation of continuous functions, which is regarded as a bridge to be set up between real function theory and probability theory. By means of this conclusion, an interesting result about function approximation theory can be obtained. The random vector representation of continuous functions is of important applications in physics. Based on the conclusion, if a large proportion of certainty phenomena can be described by continuous functions and random phenomena can also be described by random variables or vectors, then any certainty phenomenon must be the limit state of a sequence of random phenomena. Then, in the approximation from a sequence of random vectors to a continuous function, the base functions are appropriately selected by us, and an important conclusion for quantum mechanics is deduced: classical mechanics and quantum mechanics are unified. Particularly, an interesting and very important conclusion is introduced as the fact that the mass point motion of a macroscopical object possesses a kind of wave characteristic curve, which is called wave-mass-point duality.
A review on Co3O4 nanostructures as the electrodes of supercapacitors
Authors: Kelathaya Samatha , Sagar Raghavendra
Published: January 2024

Usage of supercapacitors in energy storage applications has now become a new trend due to their auspicious features. The introduction of pseudocapacitance has increased its weightage to be used in a greater number of practical applications. Electrodes are the major constituents of a supercapacitor, based on which the electrochemical performance of the supercapacitor is decided. Among the varieties of electrode materials available, transition metal oxides are the most suitable ones to fulfill the required criteria. Due to the occurrence of faradic redox reactions on the surface of electrodes, the selection of efficient and favorable electrode material plays a major role. Co3O4 (cobalt (III) oxide) is one of the most desirable electrode materials due to its various peculiar features. This paper reviews briefly several factors of Co3O4 as electrode material in supercapacitor applications. It includes comparative discussions towards different synthesize methodologies and the influence of its dimensional morphology on the electrochemical outputs like specific capacitance, energy density, and power density.
The Significance of Corporate Losses in Transfer Pricing – The Danish Supreme Court Ruling in the Maersk Oil/Total Energies Case
Authors: Baerentzen S.
Published: January 2024

On 6 September 2023, the Danish Supreme Court delivered its ruling in the largest Danish transfer pricing case to date. In addition to its considerable adjustments, the ruling has been a spectacular addition to a decade-long development in the Danish transfer pricing regulation due to the handling of corporate losses, discretionary assessments and aggregated assessments of individual transactions.
Los lenguajes poéticos y artísticos como puentes
Authors: Trujillo Rodríguez Magda Zulena , Peters Rada Victoria Eugenia , Robledo Pérez Ángela Rocío
Published: January 2024

Encontrarnos con las infancias, observarlas y escucharlas, es un desafío para cualquier investigador. Sobre todo, si tenemos en cuenta que las técnicas de recolección de la información más usadas con la población adulta, como las encuestas, las entrevistas de cualquier tipo, la recuperación de historias de vida, no logran ser significativas cuando no existe un lazo de confianza entre los niños y niñas y las personas que vienen del exterior...
Naar een gezonde samenleving voor iedereen
Authors:   Leiden University, Evers Andrea , van Dijk Sandra ,   Leiden University
Published: January 2024

In deze white paper vertellen veertien wetenschappers van de Zuid-Hollandse kennisinstituten over hun onderzoek naar diverse aspecten van gezondheid. Van preventie en overgewicht tot geestelijke gezondheid en chronische ziekten. In het bijzonder richten we ons in deze uitgave op het verkleinen van gezondheidsverschillen in de samenleving.
Challenges for the Practitioner in using Biomarkers and Genetics in Clinical Diagnosis and Treatment of Alzheimer's Disease
Authors:   Icahn School of Medicine at Mount Sinai, New York City, New York, USA, Sano Mary ,   James J Peters Veterans Administration Hospital, Bronx, New York, USA
Published: January 2024

The underdiagnoses of cognitive impairment and dementia are well documented and when the diagnosis is made it is often late in the disease course. These facts have serious consequences highlighted by the recent approval of the monoclonal antibodies for amyloid treatment for Alzheimer’s disease. The slow uptake and even serious pushback from many stakeholders may reflect their equipoise about early and accurate detection of dementia let alone its specific etiology. The Genetic marker, Apolipoprotein ε4, good clinical acumen, and biomarkers for amyloid and tau, can provide confidence in an Alzheimer’s disease diagnosis even at the mildest stages. Low utilization of these biomarkers highlights the limited knowledge of dementia care providers around mechanisms of disease and pharmacologic action. The use of biomarkers can provide confidence in clinical assessment and diagnosis, selection of agents, and assessment of safety. Disease staging using both clinical evaluation and biomarkers may soon be required to select interventions fully. Designing trials that use recognized methods for subject selection and include a wider range of outcomes, measures of patient satisfaction, and costs may improve the utilization of approved medications. Additionally, education about targeted pathologies, molecular diagnoses, and measurement of benefits can be developed for both the provider and the patient population. The presentation will highlight challenges for the practitioner in translating the clinical trial results to real-life patient populations.
A New Look at Alzheimer's: The P-Tau Cascade as the Basis for Acetylcholinesterase Inhibitor-induced Anti-neurodegeneration
Authors:   University of Texas at El Paso, Moss Donald E. , Perez Ruth G. ,   R&R Perez, LLC
Published: January 2024

The pathophysiological cascade triggered by hyperphosphorylated tau protein (P-tau) provides a unifying framework for the nerve growth factor (NGF) deficit, basal forebrain neurodegeneration, loss of cortical and hippocampal acetylcholine, and resulting dementia that is observed in Alzheimer's disease [1] (Figure 1). The P-tau cascade, including the involvement of NGF, also provides a rational mechanism by which acetylcholinesterase (AChE) inhibitors may produce their heretofore poorly understood anti-neurodegenerative benefits in AD [1] (Figure 2).
Surprising Role for Immune Cells in Mood and Memory: Impact of Regulatory T Cells
Authors:   Center for Research and Innovation, Icahn School of Medicine, New York, Pasinetti Giulio M.
Published: January 2024

Chronic stress manifests as depressive- and anxiety-like behavior while recurrent stress elicits disproportionate psychiatric responses linked to stress-induced immunological priming. Based on this evidence, we explored causative mechanisms of how dietary polyphenolics influence Regulatory T Cells and explored their role in preventing mood disorder and Alzheimer’s disease (AD) type cognitive deterioration and neuropathology. Using a conditional Treg depletion transgenic mouse model (Foxp3 cKO), we investigated the cause-effect relationship of Treg expression in mood disorder and AD phenotype preclinically. Interestingly depression and anxiety-like behavior coincide with cognitive decline and AD-type Aβ burden in Foxp3 cKO/5xTg-AD mice by transient depletion of FoxP3. Our studies tentatively support strategies to attenuate Treg immune responses as a potential preventative strategy in attenuating AD-type phenotype.
APOE Independent Associations of TOMM40 rs2075650 Genotype on Hippocampal Volume
Authors:   Department of Neurology, Rutgers University-New Brunswick, Willette Auriel
Published: January 2024

Apolipoprotein E ε4 (APOE ε4) confers the greatest genetic risk for late-onset Alzheimer's disease (AD). The adjacent Translocase of Outer Mitochondrial Membrane-40 (TOMM40) gene may increase risk through APOE ε4 independent associations with AD- sensitive brain regions like the hippocampus. ANOVA and multiple linear regression tested TOMM40 rs2075650 ('650) G vs. A genotype on total hippocampal volume using UK Biobank data (n=10,130), across all participants and by APOE haplotype groups. Age and sex interactions with TOMM40 '650 were also tested. Across participants, having both APOE ε4 and TOMM40 '650 G carriage was related to hippocampal atrophy. Among non-APOE ε4 adults, age and sex jointly modulated '650 G carriage effects. Compared to younger middle- aged adults, older women and men respectively showed modest protective and markedly detrimental associations. TOMM40 '650 G carriage may have APOE ε4-independent associations with hippocampal volume based on age and sex.
Impacts of Repeated Isolation and Dihydromyricetin on Anxiety, Cognition, and Social Behavior in Male and Female Mice: A Pilot Study
Authors:   Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, Cai Jalen
Published: January 2024

In humans, positive social interactions and relationships are essential for maintaining good mental and physical health. Insufficiency of these interactions-i.e., social isolation–is associated with negative health outcomes, including anxiety and cognitive decline. To investigate the impacts of long-term, recurrent patterns of social isolation on behavior, we developed the repeated social isolation (RSI) model, where C57BL/6 mice were subjected to social isolation, social interaction, and re-isolation, followed by the administration of 2 mg/kg dihydromyricetin (DHM). DHM is a flavonoid known to ameliorate anxiety and cognitive impairment partly via γ-aminobutyric A receptors (GABAARs) and has the potential to counteract the negative effects of social isolation. In this pilot study, mice exposed to RSI exhibited increased anxiety-like behavior and decreased cognition, while DHM partially ameliorated these changes. In the social interaction test, male RSI mice had shorter latency to attack and less social interaction, while female RSI mice avoided conflict and interaction altogether. Compared to the 4-week social isolation model, DHM showed less significance in therapeutic efficacy, especially in anxious behaviors, potentially due to 1) small sample size and/or 2). Overall, RSI increased anxiety- like behavior, reduced cognition, and led to changes in social behavior, while DHM showed some therapeutic effects. Future studies will incorporate a larger sample size and investigate the cellular or molecular changes that may explain the findings in this study.
Monosynaptic Rabies Viral Tracing Reveals Subiculum Circuit Connectivity Alterations in Alzheimer's Disease
Authors:   Department of Biomedical Engineering, University of California, Irvine, CA 92697, Ye Qiao , Gast Gocylen , Wilfley Erik George , Huynh Hanh , Hays Chelsea , Xu Xiangmin ,   Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697
Published: January 2024

Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly and causes progressive memory and behavioral impairment. Examining the changes in neural circuitry using AD model mice is an emerging strategy for a better understanding of AD neural mechanisms toward discovering new therapeutic targets. Our recent work indicates the disruption of long-range and local neural circuit connections in the hippocampus using an AD mouse model. The subiculum is the major output structure of the hippocampus and is among the earliest AD-impacted brain regions. We hypothesize that age-progressive alterations also occur in the neural circuit organization of the subiculum in the 5xFAD mouse model. To comprehensively map cell-type-specific circuit inputs, we utilized the novel viral-genetic tool of monosynaptic rabies tracing. We quantitatively assessed and compared the circuit connectivity of subiculum excitatory neurons in age-matched C57BL6 control and 5xFAD model mice at young and middle ages (3-4 months vs 8-9 months) in both sexes. The major subiculum input brain regions mapped by rabies tracing include hippocampal subregions, medial septum and diagonal band (MS-DB), subiculum (SUB), post subiculum (post SUB), visual (VIS) cortex, auditory (AUD) cortex, entorhinal cortex (EC), thalamus, and temporal association cortex (TeA). Our results reveal significant alterations in local and long-range circuit connections to the subiculum in AD model mice. The overall brain-wide connectivity strengths of subiculum inputs in aged AD model mice are weaker than in wild type mice. There are significant age and sex differences in the connectivity strengths of multiple input regions, including the hippocampal CA1, CA2, MS-DB, thalamus, RSC, VIS, AUD, and TeA. Our work provides new insights into subiculum- directed neural circuit mechanisms during AD progression and supports neural circuit disruptions as a prominent feature of AD.
Elovanoid Precursor Inhibits Lipid Peroxidation in Retinal Cells: A Comprehensive Untargeted Lipidomic Approach
Authors:   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, LA 70122, USA, Perera Rasangi M. , Calandria Jorgelina , Bazan Nicolas G.
Published: January 2024

Age-related macular degeneration (AMD) accumulates amyloid-beta peptide as in senile plaques of Alzheimer's. Also, as in other neurodegenerative diseases, enhanced reactive oxygen species (ROS) and an overall uncompensated oxidative stress (UOS) environment evolve. Oxidized phospholipids (OxPLs) cause detrimental perturbations to photoreceptor cells (PRC) and to the retinal pigment epithelial cell (RPEC), a nondividing cell derived from the neuroectoderm, essential for PRC integrity. Elovanoids (ELVs) are lipid mediators that support PRC. They are oxygenated derivatives of very long-chain polyunsaturated fatty acids (VLC-PUFAs), specifically C32:6 and C34:6. PUFA-containing phospholipids in the cell membrane are susceptible to non-enzymatic (e.g., free radical and reactive oxygen species) and enzymatic oxidation of the unsaturated components, altering their structure and function. Studies have implicated oxidized phospholipids as relevant to the etiology of aging and neurodegeneration, including age-related macular degeneration and Alzheimer's. Due to high metabolic demands, RPE cells are under constant oxidative stress.
Handling Wounds with Nur sing Knowledge at Bhayangkara Hospital Makassar City South Sulawesi
Authors: Dunggio Abdul Rivai Saleh , Djunaedi Djunaedi , Selvia Selvia , Syafruddin Syafruddin , Intang Nur , Malaha Naomi
Published: January 2024

According to Agency data Center Statistics amount death consequence accident Then cross consequence fracture on in 2020 there were 25,266 people. The most frequent fracture happened in Indonesia is fracture extremities lower. Part frequent body experience fracture that is extremities part lower. Objective Study For know description knowledge nurse to handling terrible emergency patient injured at home Sick Bhayangkara Makassar, South Sulawesi. Design study This use design descriptive is design compiled research like that appearance so that researcher can obtain answer to question study. Design study refers on type or type selected research for reach objective research, as well role as tool and guidelines for reach objective the. Results study that Length of work somebody on something organization or agency No identical with high productivity too. People with period long work no means concerned own level high proficiency. The older a person is working, not yet Of course the more skilled and experienced in his job.
Edukasi Aktifitas Fisik Pada Lansia Yang Menderita Penyakit Hipertensi Di Desa Mendatte Kabupaten Enrekang
Authors: Rante Anshar , Rasyid Djusmadi , M Warda
Published: January 2024

Hipertensi merupakan salah satu penyakit kardiovaskular yang paling umum dan paling sering terjadi pada masyarakat, terutama lansia. Jika penderita tekanan darah tinggi tidak mendapat pengobatan yang tepat, komplikasi serius dan kematian dapat terjadi. Salah satu penyebab meningkatnya jumlah penderita tekanan darah tinggi adalah kurangnya aktivitas fisik Kegiatan pelatihan dan pemberian edukasi aktivitas fisik  kepada pasien lansia dan keluarga penderita hipertensi  di lakukan oleh deosen dan mahasiswa dari Akper Sawerigading Pemda Luwu. Kegiatan tersebut dilaksanakan dengan cara mengumpulan masyarakat yang sesuai dengan sasaran yaitu pasien atau keluarga dengan penyakit hipertensi Evaluasi Hasil pelaksanaan rangkaian kegiatan yaitu pelaksanaan pelayanan terhadap lansia meliputi pemeriksaan kesehatan khususnya pemeriksaan tekanan darah dan berat badan, serta senam lansia. Semua 15 peserta yang lebih tua tidak mengetahui gerakan olahraga untuk orang dewasa yang lebih tua sampai mereka menerima informasi tentang olahraga untuk orang yang lebih tua. Setelah mendapat informasi tentang gerak motorik lansia, kelima belas partisipan lansia tersebut mengikuti  dan melakukan gerakan motorik secara akurat. Bertambahnya usia merupakan suatu tahapan kehidupan yang dilalui individu. Lansia diharapkan memiliki semangat  hidup mandiri,  percaya diri, sehat dan energik, serta memiliki kualitas hidup yang baik. Olah raga untuk lansia merupakan salah satu kegiatan  syang bermanfaat bagi lansia. Rutin berolahraga bagi lansia  membantu  menjaga kesehatan fisik pada lansia. Dengan melakukan pemberdayaan lansia dengan memberikan informasi mengenai senam lansia, diharapkan lansia dapat melakukan senam lansia secara mandiri dan meningkatkan kesehatan jasmaninya. Lansia dapat berolahraga setiap  pagi  sebelum beraktivitas

Kata Kunci: edukasi aktivitas fisik,hipertensi lansia
Settlement of Credit Problems in Four Wheel Motorized Vehicle Financing Agreements at PT. BCA Finance Jayapura Branch
Authors: Pelupessy Eddy
Published: January 2024

This research was conducted with the aim of finding out and analyzing the resolution of problem loans in four-wheeled motor vehicle financing agreements at BCA Finance Jayapura Branch as a Financing Institution for consumers and obstacles in resolving problematic credit in four-wheeled motorized vehicle financing agreements at BCA Finance Jayapura Branch as a Financing Institution to consumers. This research method is a type of empirical research, observation/survey. Observational/survey research is included in the category of observational research using a survey method, namely: the researcher directly conducts research at a predetermined location by observing and using interviews to obtain/obtain the necessary data. The results of the research reveal that the resolution of bad credit or problem credit taken by BCA Finance Jayapura Branch is generally carried out by internal settlement first through the Service Department and the Problem Account Officer (PAO) Department using deliberation and consensus. Therefore, the pattern of preventing the occurrence of problematic or potentially bad credit in distributing credit financing facilities by financial institutions to consumers must pay attention to the principle of prudence (doctrine of prudence) such as basic principles: character, capacity, capital, collateral, condition of economic, and it is necessary to carry out checks and balances and immediate checks on the validity and authenticity of the documents that are relied upon. So that it doesn't happen that financing institutions only pursue consumer quantity targets and then ignore matters relating to consumer quality, security of the parties and creditworthiness.
Pengembangan Media Scrapbook Menggunakan Model Discovery Learning Pada Pembelajaran Tematik Di Kelas IV SD Negeri 05 Pasar Tiku Tanjung Mutiara Kabupaten Agam
Authors: Jendriadi  , Marlina Meri
Published: January 2024

Penelitian ini dilatarbelakangi oleh kekurangan pada proses pembelajaran tematik materi IPA, diketahui bahwa pada proses pembelajaran dengan menggunakan media pembelajaran secara visual tersebut, belum memberikan dampak terhadap antusias peserta didik dalam mengikuti pembelajaran dan media yang digunakan belum menimbulkan sikap berpikir kritis dan aktif bagi peserta didik. Penelitian ini bertujuan untuk mengetahui pengembangan, validitas, praktikalitas dan efektivitas media Scrapbook menggunakan model  Discovery  Learning pada pelajaran IPA di kelas IV Sekolah Dasar. Jenis penelitian ini adalah R&D dengan menggunakan model 4D (define, design, development, dan dissemination). Pada tahap dissemination dilakukan uji coba terhadap 10 orang peserta didik kelas IV Sekolah Dasar. Instrumen pengumpulan data pada penelitian ini berupa lembar validasi (untuk ahli materi, ahli bahasa, dan ahli media). Instrumen praktikalitas yaitu berupa angket pendidik, peserta didik dan efektivitas dilihat dari hasil belajar peserta didik. Hasil penelitian menunjukkan bahwa media Scrapbookmenggunakan model Discovery Learning pada pelajaran IPA materi siklus hidup makhluk hidup di kelas IV sekolah dasar sangat valid, dengan skor validasi ahli materi 75% dengan kategori valid, validasi ahli bahasa dengan skor 91.6% dengan kategori sangat valid, validasi ahli media dengan skor 93,18% dengan kategori sangat valid. Dan rata-rata nilai keseluruhan validasi yaitu skor 86,59% (Sangat Valid). Untuk hasil Praktikalitas dari 1 orang pendidik didapatkan nilai rata-rata 86.1% dengan kriteria penilain Sangat Praktis, sedangkan untuk praktikalitas dari 10 peserta didik mendapatkan nilai rata-rata 91,22% dengan kriteria Sangat Praktis. Untuk hasil Efektivitas mendapatkan nilai rata-rata 90,00% dengan kriteria sangat efektif. Maka dapat disimpulkan bahwa pengembangan media Scrapbook menggunakan model Discovery Learning di kelas IV Sekolah Dasar sudah sangat valid, praktis, dan efektif.
Evaluation of the Effectiveness of CSR Programs on Community Behavior Change in Forest Conservation
Authors: Suhartanto Wiwin , Tajib Erny
Published: January 2024

Global warming can cause climate change and have a broad impact on people's lives. The increase in global temperature is caused by increased carbon emissions due to deforestation in various countries. Forests play a very important role in solving the carbon emissions problem. One source of carbon dioxide emissions throughout the world is the existence of Tropical Forests. One of the countries that has the largest tropical forest in the world is Indonesia. Kalimantan Island is one of the largest islands and has the largest forest area in Indonesia. This research was conducted at PT. Asmin Bara Bronang who runs the company's CSR program. The variables are the implementation of CSR programs, the targets of the CSR programs implemented and their impact on changes in community behavior in forest conservation. This research also discusses the relationship between implementing CSR programs with ISO 26000 and the Sustainable Development Goals. The sampling technique used was purposive sampling. Data collection was carried out through interviews with 43 sources consisting of PT Asmin Bara Bronang employees and community recipients of the CSR program. The collected data was then analyzed using the content analysis method. Research shows PT. Asmin Bara Bronang carries out a CSR program contributes to changes in the behavior of the Dayak Ngaju community in efforts to preserve Kalimantan's forests. It is hoped that this research can complement the literature regarding the implementation of CSR programs in supporting forest conservation programs
The Effect of Academic Stress, Burnout, and Class Engagement, on Cyberloafing Behavior in UNTAR Students
Authors: Zakharia Yoshua , Widoatmodjo Sawidji
Published: January 2024

Nowadays, human life cannot be separated from technology, especially the internet. The internet helps human activities, so the internet is needed, but with the presence of the internet, humans abuse the internet provided. This phenomenon is known as cyberloafing. Cyberloafing is a form of internet abuse behavior during working hours. Cyberloafing behavior itself is influenced by several variables. The variables examined in this research that influence cyberloafing are academic stress, class engagement, and burnout. This research was conducted with the aim of finding out whether the variables of academic stress, class engagement, and burnout influence a person's cyberloafing behavior. In the process of collecting research data using the Simple Random Sampling (SRS) technique by submitting questionnaires online via WhatsApp, Line and Discord with Google Form. The sample chosen was students studying at Tarumanagara University, with 371 participants studying at Tarumanagara University. The results of this research show that the class engagement and academic stress variables have a positive and significant effect, but the burnout variable has a positive and insignificant effect on cyberloafing behavior. So from this research it can be concluded that academic stress and class engagement variables influence students to carry out cyberloafing
Communication: Structure and Functions
Authors: Drif Hassan
Published: January 2024

This research aims to look into the subject of communication, control its structure and operating mechanisms, and know its functions and fields. It is an old topic that has been much talked about, viewpoints on it have multiplied, and research paths have become widespread, and the need to control its limits and rules has become a necessary matter in order to facilitate benefiting from it in life. The focus will be on four basic aspects: the limits of communication and its tools, the communicative path and its elements, the functions of communication, communication strategies and its fields, all of which highlight some of the elements that make up the act of communication and the mechanisms of its operation and functions. They highlight its importance in communicating life in its various psychological, social, cultural, educational and political dimensions and its role in communication. Achieving human existence and building channels and bridges of dialogue between nations and peoples.