bluuebunny/crossref_metadata_2025 huggingface dataset:
Global status and trends of metabolomics in diabetes: A literature visualization knowledge graph study
Authors: Li Hong , Li Liu , Huang Qiu-Qing , Yang Si-Yao , Zou Jun-Ju , Xiao Fan , Xiang Qin , Liu Xiu , Yu Rong
Published: May 2024

BACKGROUND

Diabetes is a metabolic disease characterized by hyperglycemia, which has increased the global medical burden and is also the main cause of death in most countries.

AIM

To understand the knowledge structure of global development status, research focus, and future trend of the relationship between diabetes and metabolomics in the past 20 years.

METHODS

The articles about the relationship between diabetes and metabolomics in the Web of Science Core Collection were retrieved from 2002 to October 23, 2023, and the relevant information was analyzed using CiteSpace6.2.2R (CiteSpace), VOSviewer6.1.18 (VOSviewer), and Bibliometrix software under R language.

RESULTS

A total of 3123 publications were included from 2002 to 2022. In the past two decades, the number of publications and citations in this field has continued to increase. The United States, China, Germany, the United Kingdom, and other relevant funds, institutions, and authors have significantly contributed to this field. Scientific Reports and PLoS One are the journals with the most publications and the most citations. Through keyword co-occurrence and cluster analysis, the closely related keywords are "insulin resistance", "risk", "obesity", "oxidative stress", "metabolomics", "metabolites" and "biomarkers". Keyword clustering included cardiovascular disease, gut microbiota, metabonomics, diabetic nephropathy, molecular docking, gestational diabetes mellitus, oxidative stress, and insulin resistance. Burst detection analysis of keyword depicted that "Gene", "microbiota", "validation", "kidney disease", "antioxidant activity", "untargeted metabolomics", "management", and "accumulation" are knowledge frontiers in recent years.

CONCLUSION

The relationship between metabolomics and diabetes is receiving extensive attention. Diabetic nephropathy, diabetic cardiovascular disease, and kidney disease are key diseases for future research in this field. Gut microbiota, molecular docking, and untargeted metabolomics are key research directions in the future. Antioxidant activity, gene, validation, mass spectrometry, management, and accumulation are at the forefront of knowledge frontiers in this field.
Tailored nutritional interventions: A precision approach to managing gestational diabetes mellitus
Authors: Pande Babita , Verma Henu Kumar , Bhaskar LVKS
Published: May 2024

Gestational diabetes mellitus (GDM) is a risk to maternal-fetal health due to uncertain diagnostic criteria and treatment options. Luo's study demonstrated the efficacy of customized nutritional therapies in controlling GDM. Tailored strategies led to significant body weight loss, improved glucolipid metabolism, and fewer prenatal and newborn problems. This holistic approach, which emphasizes the notion of ’chrononutrition’, takes into account optimal meal timing that is in sync with circadian rhythms, as well as enhanced sleep hygiene. Implementing tailored dietary therapy, managing meal timing, and ensuring appropriate sleep may improve results for women with GDM, opening up a possible avenue for multi-center trials.
Impact of tibial transverse transport in tissue regeneration and wound healing with perspective on diabetic foot ulcers
Authors: Mukherjee Sulagna , Im Seung-Soon
Published: May 2024

In this editorial, we comment on an article by Liao et al published in the current issue of the World Journal of Diabetes . We focus on the clinical significance of tibial transverse transport (TTT) as an effective treatment for patients with diabetic foot ulcers (DFU). TTT has been associated with tissue regeneration, improved blood circulation, reduced amputation rates, and increased expression of early angiogenic factors. Mechanistically, TTT can influence macrophage polarization and growth factor upregulation. Despite this potential, the limitations and conflicting results of existing studies justify the need for further research into its optimal application and development. These clinical implications highlight the efficacy of TTT in recalcitrant DFU and provide lasting stimuli for tissue re-generation, and blood vessel and bone marrow improvement. Immunomodulation via systemic responses contributes to its therapeutic potential. Future studies should investigate the underlying molecular mechanisms to enhance our understanding and the efficacy of TTT. This manuscript emphasizes the potential of TTT in limb preservation and diabetic wound healing and suggests avenues for preventive measures against limb amputation in diabetes and peripheral artery disease. Here, we highlight the clinical significance of the TTT and its importance in healing DFU to promote the use of this technique in tissue regeneration.
Cardioprotective effects of glucagon-like peptide 1 receptor agonists in heart failure: Myth or truth?
Authors: Nesti Lorenzo , Trico Domenico
Published: May 2024

Therapy with glucagon-like peptide 1 (GLP1) receptor agonists has raised great interest for its beneficial cardiovascular effects in preventing atherosclerosis and heart failure-related outcomes. However, while evidence about atherosclerosis consistently suggests a cardioprotective potential with class effect, controversies remain on its impact on heart failure. GLP1 receptor agonists appear to prevent hospitalization for new-onset heart failure and reduce symptoms in heart failure with preserved ejection fraction (as demonstrated by the recent STEP-HFpEF Trial). Still, GLP1 agonism has resulted in neutral or even harmful effects in patients with established heart failure with reduced ejection fraction (the LIVE trial). GLP1 receptor agonists benefit the cardiovascular system indirectly through their marked metabolic effects (improved weight management, glycemic control, blood pressure, systemic and tissue inflammation), while direct effects on the heart have been questioned. Nonetheless, weight loss alone achieved through GLP1 receptor agonists has failed in improving left ventricular functions. Tirzepatide is a dual agonist of GLP1 and glucose-dependent insulinotropic polypeptide, representing an innovative treatment option in diabetes with a major impact on weight loss and promising cardiovascular benefits. Whether this class of therapies is going to change the history of heart failure is an ongoing debate.
A Igreja do Espírito segundo Joaquin de Fiori
Authors: Besen José Artulino
Published: May 2024

A Igreja do Espírito segundo Joaquin de Fiori
A “Nova Era”: religião do Espírito?
Authors: Feller Vitor Galdino
Published: May 2024

A “Nova Era”: religião do Espírito?
Entre a política e a fé
Authors: Kestering Juventino
Published: May 2024

Entre a política e a fé
Anjos da Providência nas colônias italianas
Authors: Dos Santos Roselys Izabel
Published: May 2024

Anjos da Providência nas colônias italianas
Espiritualidade litúrgica
Authors: Goedert Valter Maurício
Published: May 2024

Espiritualidade litúrgica
A mística da ação pastoral
Authors: Kestering Juventino
Published: May 2024

A mística da ação pastoral
A espiritualidade nos Santos Padres
Authors: Cervi Henrique Ernesto
Published: May 2024

A espiritualidade nos Santos Padres
A espiritualidade na formação seminarística
Authors: Martendal Pedro Adolino
Published: May 2024

A espiritualidade na formação seminarística
A espiritualidade de um presbítero jubilar
Authors: Loch Valentim
Published: May 2024

A espiritualidade de um presbítero jubilar
Jesus Cristo e a libertação das prisões religiosas
Authors: Feller Vitor Galdino
Published: May 2024

Jesus Cristo e a libertação das prisões religiosas
Jesus Cristo e os direitos civis
Authors: Tolomini Ivo
Published: May 2024

Jesus Cristo e os direitos civis
O policial civil e o preso
Authors: Bittencourt Luís Bahia
Published: May 2024

O policial civil e o preso
Pastoral carcerária – uma experiência
Authors: Ferreira Marcos Henrique
Published: May 2024

Pastoral carcerária – uma experiência
Jesus Cristo, o Salvador único e universal
Authors: Ribeiro Hélcion
Published: May 2024

Jesus Cristo,  o Salvador único e universal
A catequese é educação da Fé
Authors: Kestering Juventino
Published: May 2024

A catequese é educação da Fé
A dívida externa na América Latina: implicações éticas na aurora de terceiro milênio
Authors: Brighenti Agenor
Published: May 2024

A dívida externa na América Latina: implicações éticas na aurora de terceiro milênio
Deus é amor
Authors: Krieger Murilo
Published: May 2024

Deus é amor
Da paternidade divina a paternidade humana
Authors: Debiasi Evaristo
Published: May 2024

Da paternidade divina a paternidade humana
Maria, modelo de caridade
Authors: Mendes Elisabeth
Published: May 2024

Maria, modelo de caridade
Dom Hélder, “Dom” de deus à sua Igreja
Authors: Besen José Artulino
Published: May 2024

Dom Hélder, “Dom” de deus à sua Igreja
Vinho novo em odres novos. Teologia e novos paradigmas
Authors: Suzin Luiz Carlos
Published: May 2024

Vinho novo em odres novos. Teologia e novos paradigmas
Amor Exigente: um programa de vida
Authors: Pinheiro Jorge
Published: May 2024

Amor Exigente: um programa de vida
Recensões
Authors: Pereira Ney Brasil
Published: May 2024

Recensões
A Igreja no Regional Sul IV
Authors: Catâneo Marciel Evangelista
Published: May 2024

A Igreja no Regional Sul IV
Tensões e desvios no âmbito da Espiritualidade
Authors: Brandes Orlando
Published: May 2024

Tensões e desvios no âmbito da Espiritualidade
Ser Igreja no Novo Milênio: a formação presbiteral
Authors: Mendes Vitor Hugo
Published: May 2024

Ser Igreja no Novo Milênio: a formação presbiteral
A questão indígena em Santa Catarina
Authors: Filho Alberto Capucci
Published: May 2024

A questão indígena em Santa Catarina
Os desafios da territorialidade Guarani
Authors: Tommasino Kimiye
Published: May 2024

Os desafios da territorialidade Guarani
A nova política de saúde indígena no Brasil
Authors: Langdon Jean
Published: May 2024

A nova política de saúde indígena no Brasil
Por uma “terra sem mal” – Mito guarani e projeto de sororidade
Authors: Suess Paulo
Published: May 2024

Por uma “terra sem mal” – Mito guarani e projeto de sororidade
A CNBB e a eclesiologia ao longo de cinquenta anos (1952-2002)
Authors: Antoniazzi Alberto
Published: May 2024

A CNBB e a eclesiologia ao longo de cinquenta anos (1952-2002)
O seminário e a questão educativa
Authors: Mendes Vitor Hugo
Published: May 2024

O seminário e a questão educativa
A espiritualidade no cotidiano a partir do Evangelho de Lucas
Authors: Loraschi Celso
Published: May 2024

A espiritualidade no cotidiano a partir do Evangelho de Lucas
Espiritualidade e fé na cultura popular
Authors: Tomazi Gilberto
Published: May 2024

Espiritualidade e fé na cultura popular
Mobilidade religiosa, pluralismo e diálogo inter-religioso
Authors: Ribeiro Antônio
Published: May 2024

Mobilidade religiosa, pluralismo e diálogo inter-religioso
Para uma recepção criativa da proposta missionária de Aparecida
Authors: Brighenti Agenor
Published: May 2024

Para uma recepção criativa da proposta missionária de Aparecida
A formação do discípulo-missionário à luz do Documneto de Aparecida
Authors: Cescon Everaldo
Published: May 2024

A formação do discípulo-missionário à luz do Documneto de Aparecida
Trabalho e justiça
Authors: Vicente Vilmar Adelino
Published: May 2024

Trabalho e justiça
Perspectivas do trabalho na sociedade catarinense
Authors: Abreu Alcides
Published: May 2024

Perspectivas do trabalho na sociedade catarinense
Padres no mundo do trabalho
Authors: Cuénot Michel
Published: May 2024

Padres no mundo do trabalho
A eclesiologia subjacente à Pastoral da Arquidiocese
Authors: Feller Vitor Galdino
Published: May 2024

A eclesiologia subjacente à Pastoral da Arquidiocese
Juventude: inquietações e esperanças
Authors: Schiochet Valdir
Published: May 2024

Juventude: inquietações e esperanças
João Paulo II e a juventude
Authors: Kestering Juventino
Published: May 2024

João Paulo II e a juventude
Os jovens e a moral
Authors: Brandes Orlando
Published: May 2024

Os jovens e a moral
Os jovens e a Eucaristia
Authors: Goedert Valter maurício
Published: May 2024

Os jovens e a Eucaristia
TDL e metodologia teológica
Authors: Silva Pedro Lucino da
Published: May 2024

TDL e metodologia teológica
As CEBs e os 500 anos de Evangelização da América Latina
Authors: Caon Luis Antônio
Published: May 2024

As CEBs e os 500 anos de Evangelização da América Latina
Evangelização e inculturação hoje
Authors: Alves Reginaldo , Socchiarelli Luis
Published: May 2024

Evangelização e inculturação hoje
Paulo Bratti – Peregrino do absoluto
Authors: Vieira Paulo
Published: May 2024

Paulo Bratti – Peregrino do absoluto
Paulo Bratti – “um pecador que Deus amou”
Authors: Pereira Ney Brasil
Published: May 2024

Paulo Bratti – “um pecador que Deus amou”
A casa nos sapienciais
Authors: Pereira Ney Brasil
Published: May 2024

A casa nos sapienciais
A casa, espaço da catequese?
Authors: Kestering Juventino
Published: May 2024

A casa, espaço da catequese?
Evangelização e moral
Authors: Brandes Orlando
Published: May 2024

Evangelização e moral
A formação sacerdotal em SC – 2 parte, os seminários maiores
Authors: Besen José Artulino
Published: May 2024

A formação sacerdotal em SC – 2 parte, os seminários maiores
O Profeta da Esperança
Authors: Niehues Afonso
Published: May 2024

O Profeta da Esperança
Paternidade-maternidade responsável
Authors: Scheid Eusébio Oscar
Published: May 2024

Paternidade-maternidade responsável
Família e liturgia
Authors: Goedert Valter Maurício
Published: May 2024

Família e liturgia
O Instituto da Família (Inflor) e os movimentos, na pastoral familiar
Authors: Martendal Carlos Jaime
Published: May 2024

O Instituto da Família (Inflor) e os movimentos, na pastoral familiar
Dom Afonso Niehues
Authors: Vieira Paulo Leonardo Medeiros
Published: May 2024

Dom Afonso Niehues
“A Igreja e a política”
Authors: Vieira Paulo Leonardo Medeiros
Published: May 2024

“A Igreja e a política”
“Sociedade civil: protagonista da transformação social”
Authors: Lisboa Armando de Melo
Published: May 2024

“Sociedade civil: protagonista da transformação social”
Os excluídos construtores do Reino
Authors: Groh Vilson
Published: May 2024

Os excluídos construtores do Reino
Os kaigang do Pinhal, excluídos em nosso Estado
Authors: Rezende Jussara Maria
Published: May 2024

Os kaigang do Pinhal, excluídos em nosso Estado
Duas formas de catolicismo. O processo da romanização em Santa Catarina.
Authors: Besen José Artulino
Published: May 2024

Duas formas de catolicismo. O processo da romanização em Santa Catarina.
Lo apache y los apaches: El ideal imposible en Ahora me rindo y eso es todo, de Álvaro Enrigue
Authors:   Tecnológico de Monterrey, México, Uraga Ramírez Mario Iván
Published: May 2024

El siguiente artículo analiza la novela Ahora me rindo y eso es todo (2018), de Álvaro Enrigue, con la finalidad de determinar la forma en que el autor aborda la extinción de los apaches en el siglo xix. Después de describir el contexto histórico en la frontera México-Estados Unidos en esa época, se muestra en qué aspectos la novela se apega a la historiografía y en cuáles no, para demostrar que Ahora me rindo y eso es todo establece un carácter ideal de lo apache claramente distinto de los apaches como entidad histórica. El artículo finaliza proponiendo una interpretación ante tal ambigüedad.
MENINGKATKAN KEMAMPUAN MENGENAL BILANGAN PADA ANAK KELOMPOK A MELALUI PERMAINAN KANTONG BILANGAN DI PAUD AZ-ZAHRA’ LEKOK
Authors: Latifah  , Windasari Indriana Warih
Published: May 2024

This research aims to improve the number recognition game using number bags. This research uses Classroom Action Research, the subjects in this research are Group A children at PAUD AZ-ZAHRA' LEKOK, totaling 16 children. Based on the results of children's evaluation analysis regarding increasing the ability to recognize numbers through the number bag game, in the pre-cycle it was 15% for 3 children, then after using number recognition through the number bag game the percentage achieved in cycle I was 70% for 11 children, and the cycle II, the percentage increased, the percentage increased to 90% for 15 children. Therefore, it can be concluded that the number recognition activity is through the number bag game for Group A children at PAUD AZ-ZAHRA'LEKOK.
Key words: games, number bags, recognizing number.
Development of Competency Standards for Good Hygienic Practices Facilitators to Enhance Food Safety Assurance
Authors: Surono Surono
Published: May 2024

This study aims to develop comprehensive competency standards for facilitators implementing Good Hygienic Practices (GHP) in the food industry, particularly to align with the new Codex Alimentarius Standard on Principles of Food Hygiene. Through a literature review approach and drawing inspiration from the Regional Model Competency Standard (RMCS), the research seeks to address existing gaps in GHP training and facilitation. The study emphasizes the importance of consistent and effective implementation of food safety practices by formulating structured competency standards covering areas such as GHP application, risk management, specific hygiene practices, and integration with Hazard Analysis and Critical Control Point (HACCP) systems. These standards are anticipated to significantly enhance food safety standards, reduce the incidence of foodborne diseases, and increase consumer confidence in food products. Furthermore, the study's implications extend to future research and policy initiatives aimed at promoting food safety through professional training and global standardization of practices.
Smart Cultivation System: Innovation Concept for Designing a Modern and Automatic Shrimp Farming Technology System Powered by Renewable Energy
Authors: Yahzunka Adel , Budi Prasetyo Agung , Rafiul Haq Muhammad , Eko Firmansyah Euaglion , Ari Prasetyo Dafit
Published: May 2024

The research presents a comprehensive exploration of energy calculations and pond design for smart cultivation systems, with a focus on shrimp ponds. Through interviews and analysis, the energy consumption of various components such as lights, waterwheels, and pumps was determined, leading to the calculation of total power consumption and the specification of necessary equipment like inverters, batteries, and solar panels. Furthermore, the study proposes the integration of renewable energy sources, such as solar and wind power, into the pond system, enhancing sustainability and reducing environmental impact. The incorporation of IoT technology facilitates real-time energy monitoring and optimization. Additionally, innovative solutions like water filtration systems and solar-powered automatic feeders are introduced to improve water quality and feeding efficiency, respectively. The application of microcontroller-based solar street lighting enhances energy efficiency and maintenance ease. A SWOT analysis underscores the strengths, weaknesses, opportunities, and threats of the proposed smart cultivation system, emphasizing its potential for energy efficiency, environmental friendliness, and long-term cost savings despite challenges such as weather dependence and technological limitations. Overall, the research underscores the feasibility and benefits of integrating renewable energy and modern technology in shrimp pond management for sustainable and efficient aquaculture practices.
Pengaruh Remunerasi Direksi terhadap Nilai Perusahaan yang Dimediasi oleh Agency Cost pada Consumer Goods Industry yang Terdaftar di Bursa Efek Indonesia
Authors: Fany Nurlia Aisyah , Iryanto Mas Budi Widiyo
Published: May 2024

This research aims to determine whether providing compensation to the board of directors can enhance the company's value. The theory utilized in this study is agency theory, which explores the relationship between owners and managers with a separation of power that leads to agency problems. The sample was collected using purposive sampling from companies in the consumer goods industry sector listed on the Indonesia Stock Exchange (BEI) during the period of 2019-2021. A total of 144 samples were examined using SmartPLS 3.0 to test the inner model and specific indirect effects. The structural model evaluation, known as the inner model, comprised tests for the determinant coefficient (R2), path coefficient, and hypothesis testing. The research model yielded an R2 value of 11%, indicating its weakness. The research concludes that compensation has a significant positive influence on company value, compensation has a significant negative impact on agency costs, agency costs have a significant negative effect on company value, and agency costs can mediate the relationship between compensation and company value.
Características clínico-epidemiológicas de pacientes con úlceras en extremidades inferiores
Authors: Lucero Guerrero Erwin Fabián , Molina Albarracín Saravik , Rodulfo Molina Jairo José
Published: May 2024

Objetivo. Determinar las características clínico-epidemiológicas de pacientes con úlceras en las extremidades inferiores, que conlleve a una orientación inicial adecuada de su etiología y manejo en la atención primaria de salud, por ser una patología frecuente y con gran impacto económico, social, y en el estado general del paciente. Metodología. Se realizó un estudio descriptivo, transversal, que incluyó 30 pacientes, evaluándose diversas variables clínicas y epidemiológicas analizadas estadísticamente y los resultados presentados en gráficos y tablas. Resultados. El 60% fueron de sexo femenino y 40% masculino, la media de edad fue 63,33 años; el 36,66% tuvo úlceras previas. En el 60 % la etiología de la úlcera fue venosa y en el 23,33% neuropática; 43,33 % presentó ulceras grado I, y 36,67 % úlceras grado II. Las comorbilidades más frecuentes fueron hipertensión arterial, insuficiencia venosa, diabetes mellitus. El correcto diagnóstico etiológico inicial basado en la anamnesis y valoración clínica, es crucial para instalar las medidas de tratamiento oportunas y evitar la cronicidad y recidiva de la úlcera.
Effect of an Optimistic Approach on Individual Life Satisfaction
Authors: Ahmad Nawaz , Vveinhardt Jolita
Published: May 2024

The study explores the impact of an optimistic approach on an individual’s life satisfaction. The study aims to understand the relationships between variables and determine whether they align with previous research findings showing that an optimistic approach benefits greater life satisfaction. The study was conducted in Pakistan. Two hundred participants were taken through purposive sampling, belonging to different socio-economic backgrounds. They were administered The Life Orientation Test (LOT) and Satisfaction with Life Scale (SWLS). To establish inter-item consistency, Cronbach alpha value was found for LOT as (α = .69-.72) and for SWLS as (α = .83-.92). Results showed a positive & relatively strong correlation (r=.473, n=200, p=.000) between the two variables through Pearson correlation test. Further, Regression was applied, resulting in a highly significant relationship f (1, 98) = p<0.05, R2=.552. Despite low optimism scores, a high level of life satisfaction was determined, and when optimism increases by 1 point, the life satisfaction score increases by 2,141 points. Based on the results of the study, the influence of optimism on life satisfaction in the context of Pakistan is discussed.
The Effect of Melatonin on Metabolism and the Sleep-Wake Cycle
Authors: Kurdiukova Daria Sergeenva , Gasanbekov Gusen Muratovich , Pavlov Bogdan Vladimirovich , Kulikova Irina Alexandrovna , Martynova Galina Dmitrievna , Kislinskaya Natalia Alexeevna
Published: May 2024

The aim of this study was to investigate the influence of melatonin on metabolism and the implementation of the sleep-wake cycle. Methodology. Publications for this review were collected from PubMed, MedLine, and Google Scholar databases. Results. Melatonin is the main hormone that communicates the main circadian clock, located in the suprachiasmatic nucleus of the hypothalamus, and the peripheral biological clock located in brain cells and other organs. Melatonin production is related to day and night cycles, with peak production of the hormone occurring at night. Considering the pathophysiological mechanisms triggered by melatonin deficiency, the question reasonably arises about the possibilities of treating metabolic disorders (including type 2 diabetes), cardiovascular pathology and sleep disorders with melatonin preparations. Domestic and foreign publications provide reports of the clinically successful use of such drugs to improve sleep quality, increase sensitivity to glucose, lower blood pressure, reduce myocardial ischemia, and improve anthropometric parameters. All this makes melatonin a promising drug for managing cardiovascular risks against the background of metabolic disorders.
The Impact of the COVID-19 Pandemic on Physical Activity and Quality of Life Among Ukrainian Students
Authors: Karabanov Yevhen , Konokh Anatolii , Osipov Vitalii , Syvokhop Eduard , Marionda Ivan
Published: May 2024

The COVID-19 pandemic continues to pose serious challenges to society. Strategies such as social distancing are employed to reduce its spread; however, this can lead to a sedentary lifestyle. Many people report difficulties in maintaining a healthy level of physical activity during the pandemic. The aim of this study was to examine the levels of physical activity and quality of life among Ukrainian university students during the COVID-19 pandemic. A diagnostic questionnaire was used, and the International Physical Activity Questionnaires (IPAQ) were employed to assess participants' physical activity levels. The study involved 662 students from three Ukrainian universities. A significant decrease in physical activity and an increase in sleep duration were observed during the COVID-19 pandemic. One of the main advantages of this study was the use of both cross-sectional and longitudinal analyses. The study also allowed for the evaluation of two types of behavior: physical activity and sleep. The conclusions. After the onset of the COVID-19 pandemic, physical activity was low in 90% of students, amounting to 791±7.3 MET, with a significant amount of time (8.6±1.2 hours) spent on sleep, while less than half of the participants (40.2%) met the recommended physical activity guidelines.
Evaluación de la actividad antimicrobiana de extractos de especies vegetales en bacterias patógenas de importancia en salud pública
Authors: Carmona Vázquez Perla Karina , Ramírez Quintanilla Laura Yanneth , Hernández Mendoza José Luis , Oliva Hernández Amanda Alejandra , García León Israel , Quiroz Velásquez Jesús Di Carlo
Published: May 2024

Las infecciones por bacterias como Staphylococcus aureus, Escherichia coli y Salmonella spp afectan tanto a humanos como a animales. Estas bacterias han adquirido resistencia a los antibióticos convencionales, lo que dificulta su tratamiento y supone un riesgo para la salud. Por eso, se investigan otras opciones naturales para combatirlas, como los extractos de plantas. El objetivo del presente trabajo fue evaluar la actividad antimicrobiana de extractos de plantas para el control de bacterias patógenas de relevancia médica. Como metodología, se utilizaron cepas de Staphylococcus aureus, Escherichia coli y Salmonella spp., siguiendo los métodos descritos por Duquense et al., 2015 y la NOM-110-SSA1-1994. Y para elaborar los extractos metanólicos se usaron muestras vegetales como: clavo (Syzygium aromaticum), ajo (Allium sativum), jengibre (Zingiber officinale), vainilla (Vanilla planifolia), menta (Mentha spicata), cilantro (Coriandrum sativum), perejil (Petroselinum crispum), estafiate (Artemisia ludoviciana) y bayas como fresa (Fragaria vesca) y zarzamora (Rubus ulmifolius), comprados en mercados populares en Reynosa Tamaulipas. El resultado de las pruebas antibióticas mostró que el extracto metanólico más efectivo fue el de clavo, seguido por el extracto metanólico de ajo. Por lo tanto, estos extractos vegetales podrían ser una opción para el control de bacterias patógenas relevantes desde el punto vista médico.
Quality and Safety Standards in Health Services: Development and Implementation
Authors: Petryk Serhii , Zenkina Valentyna , Stepanenko Viacheslav , Shevchuk Anatolii , Yurchenko Kostiantyn
Published: May 2024

Aim. This research work aims to identify the characteristic features of the development and implementation of quality standards for patient monitoring and safety services in medical institutions, in order to improve quality based on the developed digital model, and describe the requirements for the implementation of quality control according to ISO 9001:2015 and ISO 15189:2022 Standards. Methods. The work uses a digital model of the Traumatology Center, built using the AnyLogic programming environment. This model is designed to identify and analyze effective solutions for implementation, such as patient registration processes, staffing, scheduling of specialized departments, identification of clinical characteristics and early symptoms of diseases to prevent complications during the incubation period. Results. It was discovered that modern wireless technologies and data analytics can be used to develop a remote health monitoring system, enabling early detection of chronic diseases to prevent complications. The scientific novelty of the study consists in the development of a sequence for the implementation of documentation on standardization and quality of service in medical institutions to prevent harm to patients, and improve their safety with the help of a complex of measuring devices and technologies. of the information.
Desarrollo de una aplicación interactiva en R Shiny para la visualización de indicadores de servicio hospitalario en el Hospital Pediátrico Alfonso Villagómez Román
Authors: Aguilar-Reyes Johanna Enith , Edwin Fernando Edwin Fernando , Morocho-Barrionuevo Tania Paulina , Funes-Samaniego Liliana Alejandra
Published: May 2024

El artículo aborda la necesidad de una plataforma interactiva para representar los indicadores de servicio en el Hospital Pediátrico Alfonso Villagómez Román de Ecuador. Se desarrolló una aplicación web en R Shiny para mejorar la visualización de estos indicadores. Los objetivos incluyeron la creación de la aplicación, diseño de almacenes de datos, carga de información relevante e integración en la gestión administrativa. La justificación radica en la importancia de una gestión eficiente de indicadores hospitalarios y el potencial tecnológico en salud. Estos indicadores son cruciales para evaluar la calidad de la atención médica y respaldar decisiones informadas. La metodología abarca desde la planificación hasta la evaluación, con R Shiny por su capacidad para crear visualizaciones interactivas. Los resultados incluyen una aplicación web exitosa, almacenes de datos organizados y una integración de la gestión administrativa del hospital. En conclusión, este trabajo logró su objetivo al crear una herramienta valiosa para la gestión y toma de decisiones en el ámbito hospitalario, contribuyendo así a una administración más eficiente y a la optimización de recursos.
Tendencias actuales en el uso de la informática aplicada a los procesos de la administración de empresas: Reflexiones teóricas
Authors: Toalombo-Vargas Paula Alexandra , Andino-Nájera Pablo Rigoberto , Arboleda-Álvarez Luis Fernando , Santillán-Lima Juan Carlos
Published: May 2024

La creciente digitalización de los procesos administrativos se presenta como una tendencia irreversible en el manejo de los datos que procesa en todo momento la administración pública y la empresa privada; en este contexto de cambios tecnológicos vertiginosos, el objetivo de la investigación fue determinar las tendencias actuales en el uso de la informática aplicada a los procesos de la administración; objetivo que se justifica en razón de ser de la informática la ciencia de los métodos, técnicas y procesos para almacenar, procesar y transmitir información en formato digital. Metodológicamente la investigación se desarrolló como un ensayo desarrollado mediante el examen critico de fuentes documentales publicadas en revistas científicas de alto impacto y fuentes académicas autorizadas en el tema. Los resultados obtenidos permiten concluir que las tendencias actuales en el uso de la informática en los procesos de gestión evolucionan constantemente, centrándose en la inteligencia artificial, la computación en nube, la automatización y la informática de nueva generación. Estas tecnologías y herramientas tienen el potencial de mejorar enormemente la toma de decisiones y capacitar a los empleados de las empresas.
Métodos de imputación por regresión, imputación por moda, imputación múltiple y árboles de decisión para variables categóricas en perspectiva comparada
Authors: Mejía-Peñafiel Edwin Fernando , Aguilar-Reyes Johanna Enith , Bolaños-Logroño Paulina Fernanda , López-Ortega Jorge Rigoberto
Published: May 2024

La imputación por regresión, la imputación por moda, la imputación múltiple y los árboles de decisión son métodos utilizados para tratar valores faltantes en variables categóricas. En este contexto, el objetivo de la investigación consiste en definir los criterios para comparar estos métodos, estableciendo en el proceso sus semejanzas y diferencias conceptuales. En lo metodológico, se hizo uso del método comparativo y del análisis epistemológico como condición de posibilidad para entender el alcance y significo de cada uno de estos métodos, con arreglo al acopio de fuentes documentales de comprobado valor científico. Aunque parciales y limitados, los resultados obtenidos respaldan la hipótesis de que la estadística es una ciencia en desarrollo que requiere del dialogo inter-metodológico, como condición de posibilidad para obtener resultados más precisos, incluso cuando faltan ciertos datos en una ecuación. En última instancia, este trabajo sienta las bases para futuras investigaciones que podrían profundizar en la perspectiva comparada de ciertos métodos y herramientas de investigación, como los que se enuncian en el título del artículo.
Developing and Implementing a Value-Based Operations and Maintenance Performance Management in Nigeria Electric Power Industry
Authors:   Department of Mechanical Engineering, Federal University of Technology Ikot Abasi, Nigeria., Usungurua E. O. , Akpan W. A. ,   Department of Mechanical Engineering, Federal University of Technology Ikot Abasi, Nigeria., Ukut A. I. ,   Department of Mechanical Engineering, Akwa Ibom State Polytechnic, Ikot Osurua,Ikot Ekpene, Nigeria, Hanson A. E. ,   Department of Mechanical and Aerospace Engineering, University of Uyo, Uyo, Nigeria.
Published: May 2024

The Nigeria electric power industry is yet to recognize and adjust management practices, especially those concerned with operations and maintenance, to the changed and changing business conditions in electric power production. Hence, there is a need to review the organization’s operations and maintenance policies. This paper intends to develop a value-based operations and maintenance performance which could be implemented in Nigeria electric power stations. An attempt was made to develop a framework for effective management of operations and maintenance performance which will link results to performance drivers. Furthermore, balance scorecard concept was included. The paper emphasized on value-added and intellectual capital in operations and maintenance in the emerging business environment, and stressed that there is a need to move from corrective maintenance or time-based maintenance to a long-term business-oriented approach.
A Study of Certain Physiological Characteristics of Infected Children with Diarrhea Owing to Entamoeba Histolytica and Related Bacteria in Children of Thi-Qar Province
Authors:   Aouda Al-Salehy College of Nursing, Thi-Qar University, Iraq, Khairullah Zainab , Nasar Dmoaa Majid ,   Department of Pharmaceutical sciences, College of pharmacy, University of Thi-Qar, Thi-Qar 64001, Iraq, Aziz Ahmed ,   Department of Pharmaceutical sciences, College of pharmacy, University of Thi-Qar, Thi-Qar 64001, Iraq
Published: May 2024

The present study aims to evaluate the physiological characteristics of E. histolytica and common pathogenic bacteria in children under the age of five who are experiencing diarrhoea. The present investigation was carried out at Bint Al-Huda Teaching Hospital for Women and Children and Al-Mousawi Hospital under the jurisdiction of Thi-Qar Province. The present study observed a significant decrease in the count of red blood cells, haemoglobin blood, and hematocrite in patients infected with E. histolytica and pathogenic bacteria, as well as in patients infected with E. histolytica alone, compared to the control groups. However, there was no significant difference within patients for both males and females. The blood parameters of male and female patients with diarrhoea (plate late test) exhibited a statistically significant increase (P ≥ 0.05) in comparison to the control group. There was no statistically significant difference (P ≥ 0.05) observed between male and female patients with diarrhoea produced by E. histolytica and pathogenic bacteria, compared to those with diarrhoea caused only by E. histolytica. There were no significant changes (P ≥ 0.05) in any blood parameters (mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration) between male and female patients with diarrhoea and the control group. The findings of the study revealed that there was no statistically significant increase (p < 0.05) in the levels of Aspartate aminotransferase, Alanine aminotransferase, and Alkaline phosphatase in patients infected with E. histolytica. However, in patients infected solely with E. histolytica, there was a significant increase in enzyme levels compared to both the pathogenic and control groups. The present study demonstrated a notable elevation in the levels of urea and creatinine among male and female patients diagnosed with diarrhoea in comparison to the control group. However, no statistically significant difference was observed between male and female patients with diarrhoea caused by E. histolytica and pathogenic bacteria, as compared to those with diarrhoea solely caused by E. histolytica.
Un enfoque integral y colaborativo en el manejo de la diabetes mellitus
Authors: Aranguren Florencia
Published: May 2024

En el complejo escenario médico actual, los profesionales de la salud que acompañamos a las personas que viven con diabetes mellitus (DM) atravesamos tiempos desafiantes, en los que la actualización permanente, desde todas las diferentes aristas que comprenden el correcto seguimiento del paciente, parece difícil de abarcar.
Se estima que se publican entre 150 y 200 artículos científicos diarios sobre DM a nivel mundial. Esto incluye una amplia gama de investigaciones, desde estudios básicos, clínicos y ensayos controlados hasta revisiones sistemáticas, metaanálisis y estudios epidemiológicos. Sin embargo, son tantos los avances en la comprensión de la fisiopatología, el desarrollo de nuevas terapias y tecnologías, y la identificación de mejores prácticas clínicas que pueden beneficiar a nuestros pacientes y cambiar de forma abismal su evolución y la aparición de complicaciones, que estar actualizados con información de calidad se convierte en un imperativo ético.
En este contexto, la Sociedad Argentina de Diabetes se erige como un faro de guía y unificador de esfuerzos, que congrega a expertos de diversos campos y puntos del país para forjar un enfoque integral y colaborativo en el manejo de esta enfermedad.
Con este espíritu, el presente suplemento de recomendaciones representa el fruto del esfuerzo y la dedicación de múltiples Comités, cada uno enfocado en áreas específicas de la atención médica de la DM, pero todos con la premisa fundamental del trabajo en equipo.
Comité de Educación. Transición de adolescentes con diabetes mellitus tipo 1 de equipos pediátricos a equipos de adultos
Authors: Grabois Florencia Sofía , Arrigo Ángeles , Trabuco Gabriela , De Lapertosa Silvia Gorbán , López González Eva , Ruiz Morosini María Lidia
Published: May 2024

El período de transición se define como un proceso activo, planificado y multidisciplinario que abarca distintas necesidades médicas, psicosociales y educativas de la población adolescente con el objetivo de prevenir complicaciones y favorecer la adherencia al tratamiento.
El objetivo primordial es entrenar a las adolescencias con diabetes mellitus (DM) para que adquieran la autonomía e independencia necesarias para un adecuado control de su enfermedad. Estas aptitudes no se alcanzan en la mayoría de las personas antes de los 16-18 años.
Los programas de educación terapéutica en personas con DM1 en la etapa de la adolescencia tienen por objetivos facilitar el proceso de transición, lograr la autonomía y el empoderamiento con el fin de prevenir riesgos de complicaciones agudas como la cetoacidosis, la depresión y la interacción de la medicación con sustancias como el alcohol, entre otros.
La adolescencia es una etapa biológica y social en la cual se producen cambios significativos, a los que se le agrega el paso del equipo de cuidados en salud pediátrico al del adulto.
Esta etapa es considerada un momento de grandes desafíos en el cuidado de la DM que debe planificarse y que requiere de la preparación del paciente y su familia. De esta manera, los posibles riesgos podrían superarse unificando criterios entre los servicios pediátricos y los de los adultos.
Estas recomendaciones brindan herramientas que sirvan a los profesionales especializados en DM a realizar programas de educación en la transición para reducir el abandono del tratamiento y las complicaciones asociadas en pacientes adolescentes con DM1 durante la transición de equipos pediátricos a equipos de adultos.
Para ello, se realizó una búsqueda bibliográfica de las publicaciones en el tema de los últimos 5 años y se seleccionaron las más relevantes. Los distintos artículos sugieren que la transición de la atención pediátrica a la de adultos debe comprender un cronograma de detección de complicaciones, apoyo psicológico, actividades de pares con tiempo acordados, y desaconsejan una transferencia repentina e imprevista. Esto incluye la realización de programas de educación que acompañen esta etapa de vulnerabilidad.
Comité de Oftalmopatía ¿Es la patología oftálmica en diabetes una herramienta útil para categorizar el riesgo cardiovascular?
Authors: Issa Claudia Marcela , Domina María Candelaria , Payero María Laura , Lima Santiago
Published: May 2024

Actualmente nadie duda que la aparición de complicaciones microvasculares en la diabetes mellitus (DM) está relacionada con la hiperglucemia crónica. En la recientemente publicada guía de la European Society of Cardiology (ESC) 2023 para el manejo de la enfermedad cardiovascular (ECV) en DM, se establece nuevamente que la presencia de la retinopatía diabética (RD) junto con la nefropatía y la neuropatía colocan al paciente en categoría de muy alto riesgo cardiovascular. Categorizar correctamente el riesgo cardiovascular del paciente nos permite prevenir y/o retrasar eventos cardiovasculares mayores, y tomar precauciones adecuadas frente a intervenciones quirúrgicas para evitar complicaciones intra o perioperatorias. La recomendación de este Comité, previo al inicio de la medicación para la DM, es realizar una evaluación oftalmológica completa que incluya fondo de ojo y otros estudios oftalmológicos, como la retinofluoresceinografía y la tomografía de coherencia óptica, para la mejor categorización del riesgo de la persona con DM y la elección adecuada de la medicación a iniciar para el control glucémico.
Selected models of speech perception by students 5 semester English Education Study Program Universitas Nias of english during lecturing
Authors: Harefa Afore Tahir , Halawa Mercy Dwiyul , Hulu Delan Septiani , Telaumbanua Enjel Tris Jelita
Published: May 2024

Understanding speech (speech perception) is an important ability that English language students must master. There are several theoretical models of speech comprehension that attempt to explain the cognitive and linguistic processes underlying this ability. As for speech perception models, 1) Motor Theory of Speech Perception, 2) Analysis-by-Synthesis, 3) Group Model, 4) Fuzzy Logic Model, 5) TRACE Model. This study aims to find out what kind of speech perception model used by students in lectures, especially in the process of teaching and learning English. Specifically, this research is classified as qualitative research. To collect data, the participants studied were the 5th semester population of the English education study program, especially at Nias University. Random samples were used and the samples were 7 people from class A. From the results that have been obtained, there are 4 (four) students classified as using the Cohort model, 2 (two) students classified as using the Motor Theory model, and 1 (one) student classified as using the Fuzzy Logical Model, so we can conclude that most students use the Cohort model they often use this model in English learning activities every day.
Penggunaan Media Flipbook Digital untuk Meningkatkan Motivasi Belajar Siswa Kelas V Sekolah Dasar Materi Cahaya dan Sifatnya
Authors: Meilinda Ghina , Sunaengsih Cucun , Sujana Atep
Published: May 2024

This research has the main problem, namely the lack of use of digital media and the lack of motivation to learn in class V students at SD Negeri 1 Maniskidul. The aim of this research is to find out how learning is implemented using digital flipbook media and how students' learning motivation is after using digital flipbook media regarding light and its properties. The research method used is qualitative with a descriptive study design, data collection is carried out by observation, interviews and documentation. The research subjects studied were the class V homeroom teacher and class V students of SD Negeri 1 Maniskidul, totaling 30 people, namely 15 boys and 15 girls. The conclusion produced during the research was that the implementation of learning using digital flipbook media was researched through observations of teachers and class V students with very good results. Meanwhile, observations and interviews were carried out on fifth grade elementary school students with a total of 30 students, after using digital flipbook media there was an increase in motivation, the results became 2 categories derived from the learning motivation indicators themselves, namely 27 students who met the 8 indicators, and There were 3 students who met the 6 indicators.
Clinical and Therapeutic Aspects of Ischemic Stroke in Atrial Fibrillation at the Neurology Department of CHU Conakry
Authors:   Department of Neurology, Conakry University Hospital, Guinea, MA Bangoura , CO Soumah ,   Department of Neurology, Conakry University Hospital, Guinea, ML Touré ,   Department of Neurology, Conakry University Hospital, Guinea, MI Diallo ,   Department of Neurology, Conakry University Hospital, Guinea, SD Barry ,   Department of Neurology, Conakry University Hospital, Guinea
Published: May 2024

Introduction: The main cause of ischemic stroke in our setting is atrial fibrillation. The aim of this study was to evaluate the clinical and therapeutic aspects of atrial fibrillation during ischemic stroke. Material and Methods: We conducted a retrospective descriptive study lasting one year from November 1, 2020 to November 31, 2021, involving all patients with ischemic stroke diagnosed by CT or MRI. We included patients with atrial fibrillation confirmed by a 12-lead électrocardiogrammes (ECG) or a 24-hour ECG holter. Thromboembolic risk was assessed by the CHA2DS2Vasc score and bleeding risk by the HAS-BLED score. Results: A total of 1,400 patients (19.64%) were enrolled. Mean age was 57.3 +/-16.64 years, predominantly female (54.5%), with hypertension as a risk factor (45.09%). The mean NIHSS score was 17.9 +/-3.2, associated with disorders of consciousness (44.36%) and hemiplegia (100%). atrial fibrillation was persistent in 54.90% of cases. A CHA2DS2-VASc score ≥ 2 was found in 94.9% of cases, and a low HAS-BLED score in 73% of cases, for whom Rivaroxaban was the first-line treatment in 76.72% of cases. Conclusion: This study has shown that atrial fibrillation is common in cardioembolic cerebral infarctions with age and hypertension as risk factors.