bluuebunny/crossref_metadata_2025 huggingface dataset:
DYNAMICS OF ANGKUL-ANGKUL SAKA JAJAR DEVELOPMENT IN SUSUT DISTRICT, BANGLI REGENCY
Authors: I Wayan Yudhasatya Dharma  , Ni Wayan Yusi Armini
Published: June 2023

The Balinese Hindu community is known as a traditional society, where traditional society is a society that in its daily life still applies ancient systems or old customs in various settings of its life. Their lives have not been overly influenced by changes that come from outside their social environment. The life of traditional society still tends to uphold certain traditions that exist in society as a transformation of values ​​that are considered appropriate. Traditional community culture is the result of adaptation to the surrounding natural and social environment without receiving outside influences (Ifzanul, 2010: 15). Balinese society as adherents of a traditional cultural system is formed from many complex elements, including religious systems, politics, customs, language, tools, clothing, buildings and works of art. Angkul-Angku Saka Jajar is one of the cultures of the people of Susut District, Bangli Regency where this building is part of the spatial layout of the community settlement which is also a sign of the social identity of the community. Where in general Angkul-Angkul Saka Jajar is a sacred building and it is agreed that it can only be built by a village leader called Mekel or Perbekel.
Oriented to this background, the following problems can be formulated: (1) How is the conception of the development of Angkul-Angkul Saka Jajar as a symbol of social identity for the Hindu community in Susut District, Bangli Regency?, (2) How is the implementation of the construction of Angkul-Angkul Saka Jajar as a symbol of identity? the Hindu community in Susut District, Bangli Regency?, (3) What values ​​are contained in Angkul-Angkul Saka Jajar as a symbol of social identity for the Hindu community in Susut District, Bangli Regency?. In general, this study aims to reveal the meaning behind the existence of Angkul-Angkul Saka Jajar as a symbol of social identity for the Hindu community in Susut District, Bangli Regency. In this study using structural functional theory, meaning theory, and value theory. The source of the data in this study was the direct (primary) source obtained in the field as a result of observation and scrutiny of the existence of Angkul-Angkul Saka Jajar as a symbol of social identity for the Hindu community in Susut District, Bangli Regency. While indirect (secondary) sources can be obtained through books, articles, written documents, and so on from libraries or other places. Primary and secondary sources can be combined or cross-checked to obtain truly accurate and accountable data. The informants in this study were determined purposively. The data collection used here includes direct observation of the research object (observation), interviews, and literature studies. After the data is obtained, it is analyzed by reducing, then presenting the data, and drawing conclusions.
Generation of Multiple-Revolution Many-Impulse Optimal Spacecraft Maneuvers
Authors: Arya Vishala , Şaloğlu Keziban , Taheri Ehsan , Junkins John L.
Published: June 2023

Impulsive trajectories provide time- and [Formula: see text]-reachability insights. Two novel homotopy-based methods are proposed for generating optimal many-impulse, multirevolution maneuvers. The first method is based on the continuation over the specific impulse value, which is shown to enhance convergence performance of the resulting two-point boundary-value problems. The second method is based on the formulation of impulsive trajectories using a linear acceleration term. The two methods are used in a hybrid framework. The utility of the proposed methods is demonstrated on four problems: Two interplanetary trajectories 1) from Earth to Mars, 2) from Earth to asteroid Dionysus, 3) a planet-centric transfer maneuver from a geostationary transfer orbit (GTO) to geostationary orbit (GEO) consisting of 21 revolutions, and 4) a 50-revolution transfer from the considered GTO to a circular orbit at the first Lagrange point (L1) of the Earth–moon system. The last two problems leading to 18 and 50 impulses are tackled to give an optimal near-impulsive solution. The impulsive solution with 18 impulses is shown to satisfy Lawden’s conditions.
Long-Term Orbital Lifetime Prediction of Highly Eccentric Orbits: A Statistical Approach
Authors: Luo Xuhui , Wang Yue , Zhang Yao , Liu Jing
Published: June 2023

This paper concentrates on the long-term orbital lifetime prediction of highly eccentric orbits (HEOs) based on two-line element sets via a statistical approach. Due to the significantly different evolution characteristics of low- and high-inclination HEOs induced by different orbital resonances, two area-to-mass estimation methods are proposed, respectively. The resonance phenomena encountered in the HEO region strongly affect the orbital evolution and cause high sensitivity. Therefore, a statistical approach is adopted to handle these effects and correctly estimate low-inclination HEO lifetime. We use the Monte Carlo method and kernel-density estimation to calculate the probability distribution of the orbital lifetime. Finally, the performance of the method is assessed by the actual orbital lifetimes of space objects that reentered from HEOs in the past 50 years. The results indicate that our statistical approach can improve the orbital lifetime prediction accuracy to a large extent, especially for the low-inclination HEOs. If a relative error of 15% is adopted as the error tolerance, compared with the traditional method based on a single orbital propagation, our statistical method can increase the success rate from 40% to more than 70%. For the high-inclination HEOs, the objects with a relative error below 15% account for more than 90%.
Numerical Investigation of High-Lift Propeller Positions for a Distributed Propulsion System
Authors: Firnhaber Beckers Mário , Schollenberger Michael , Lutz Thorsten , Bongen Dustin , Radespiel Rolf , Florenciano Juan L. , Funes-Sebastian David E.
Published: June 2023

The aerodynamic propeller–wing interactions of a distributed propulsion system in a high-lift scenario were investigated. A [Formula: see text] computational fluid dynamics parameter study with steady-state Reynolds-averaged Navier–Stokes simulations of a wing segment and an actuator disk was conducted to determine the sensitivities and correlations of design parameters at high angles of attack. The parameter study revealed a significant lift augmentation (about [Formula: see text] at [Formula: see text]) but a decrease in propulsive efficiency (about [Formula: see text] at [Formula: see text]). With increasing angle of attack, the lift augmentation effect decreased (down to about [Formula: see text] at [Formula: see text]), whereas the propulsive efficiency decreased further (to about [Formula: see text] at [Formula: see text]). The design parameter presenting the largest sensitivity toward system performance was the vertical propeller position. The distance between the propeller and the wing had a comparatively minor effect, as long as the vertical propeller position was adapted accordingly. Propulsive performance could be significantly improved by tilting the propeller downward toward the inflow (by about [Formula: see text] for [Formula: see text] as compared to a nontilted propeller). A spanwise clustering of propellers (tip-to-tip distance of [Formula: see text]) appears to be beneficial when considering a predetermined amount of distributed propellers.
What is the most effective technique and composite for bonding aligner attachments to primary enamel?
Authors: Çokakoğlu Serpil , Nalçacı Ruhi , Tozlu Murat , Altıntaş Subutay Han
Published: June 2023

Objectives:

This in vitro study evaluated the shear bond strength (SBS) of aligner attachments bonded to primary teeth with different techniques and composites.

Material and Methods:

Eighty attachments were prepared using five composites: An aligner composite (GC aligner connect [GAC]), two flowable restorative composites (G-aenial universal injectable and Estelite universal super low flow), and two one-step orthodontic composites integrated with primer (GC ortho connect flow and GC ortho connect). Aligner and restorative composites were applied with self- or total-etch (SE or TE) modes of universal adhesive (G-Premio Bond). Self-adhering composites integrated with primer were applied after acid etching. Excessive composites were removed with tungsten carbide burs after the polymerization of resin attachments. All primary teeth were exposed to thermocycling. Bond strength was determined with a universal testing machine. Remnant resin attachment was scored with the resin attachment remnant index. Kruskal–Wallis, Mann–Whitney, and Chi-square tests were used for statistical analyses.

Results:

The self-etching technique demonstrated lower SBS values compared to total-etching and self-adhering groups regardless of composite type. The highest SBS was found with aligner composite (GAC) and the total-etching technique. Self-adhering composites showed sufficiently high SBS values comparable with GAC and TE bonding techniques. The amount of remnant attachment was significantly higher in the total-etching and self-adhering groups compared to SE bonding with GAC (P < 0.05).

Conclusion:

Self-adhering orthodontic composites can be preferred to simplify the bonding of aligner attachments to primary enamel after acid etching.
Unusually large craniopharyngioma: A case report
Authors: Karmakar Madan , Dakshit Debashis , Saha Sudipta , Bose Arnab
Published: June 2023

Background:

Craniopharyngiomas are benign slow-growing tumors of the central nervous system originating from squamous remnants of incompletely involuted craniopharyngeal duct. Craniopharyngiomas are said to be “giant” when they attain sizes of 5–6 cm or more.

Case Presentation:

Here, we present a case of unusually large craniopharyngioma in a child, which, to the best of our knowledge, is the largest craniopharyngioma reported in the literature. The provisional diagnosis of craniopharyngioma was established using computed tomography and magnetic resonance imaging.

Conclusion:

Craniopharyngiomas are to be considered in the differentials for sellar and suprasellar region lesions causing mass effect. The provisional diagnosis is established by imaging but definitive diagnosis always requires histopathology.
Prevalence of antinuclear antibodies among healthy blood donors: An experience of a regional blood transfusion center
Authors: Sharma Narayan , Sharma Vanshika , Sharma Santosh Kumar , Thakur Sanjay Kumar , Singh Sompal
Published: June 2023

Objectives:

Antinuclear antibodies (ANAs) are antibodies directed against one or more molecules within the nucleus. Although ANA is present in patients suffering from connective tissue diseases, few reports reveal the presence of ANA in a healthy population. The present study aimed to identify the prevalence of ANA in healthy blood donors.

Materials and Method:

Blood samples from 370 healthy blood donors were included in the present study. To detect serum ANA, an indirect immunofluorescence technique was used using HEp-2000 slides. A titer of 1:80 was used and the type of pattern (if positive) cases were also noticed.

Results:

Out of 370 healthy donors, there were 187 males and 183 females (M: F = 1.02:1). ANA was detected in four out of 370 samples (1.081%). All the positive donors were female (100%). Among all the positive cases, three cases showed a speckled pattern and one showed a homogenous pattern at 1:80 dilution.

Conclusion:

In conclusion, there is a low prevalence of ANA positivity among healthy individuals. Although, along with clinical signs and symptoms, ANA is diagnostic of autoimmune disease, the mere presence of ANA is not synonymous with the presence of clinically significant autoimmune disease.
Assessing the resilience potential of the Russian Arctic cities: the factor of economic specialization
Authors:   Lomonosov Moscow State University, Nikitin B.V.
Published: June 2023

This paper proposes an original methodology for assessing the impact of economic specialization on the resilience potential of Russian Arctic cities. The author understands the resilience as the ability of urban economies to adapt to crises, especially structural ones. He considers the key concepts of urban and regional development, in which the impact of economic specialization factor on resilience are assessed. The author takes into account the specifics of the Arctic urban systems that evolve focusing mainly on the resource development of the territory. As a result, he ranks 28 Russian Arctic cities on the resilience potential basis. The ranking consists of four quantitative indicators with equal weight. These are the degree of diversification of the economy in terms of employment structure, the level of the extractive industry development, the share of innovative firms and the patent activity level. The cities differ mostly by the last two indicators responsible for the development of human capital and the generation of new niche industries of specialization. In terms of employment diversification and dependence on the extractive industry, the distribution is more even. Regional capitals, research and university centres acquire higher scores of resilience potential. By contrast, factors of location in suburban zone, on the remote periphery with low infrastructure provision or in areas with a high concentration of mineral resources negatively affect the assessment of the resilience of the cities. The ranking methodology can be applied to identify the risks Arctic cities are likely to face if they lose their current specialization.
Study of the risk for plant ecosystems of the Russian Arctic from atmospheric pollution in a changing climate (1980—2050)
Authors:   A.M.Obukhov Institute of Atmospheric Physics Russian Academy of Sciences, Makosko A.A. , Matesheva A.V. ,   A.M.Obukhov Institute of Atmospheric Physics Russian Academy of Sciences, Lysova O.V. ,   A.M.Obukhov Institute of Atmospheric Physics Russian Academy of Sciences
Published: June 2023

The authors studied the risk dynamics for plant ecosystems on the mainland of the Russian Arctic from atmospheric pollution by sulfur dioxide from potential sources (including sources of transboundary pollution) in 1980—2050 in terms of the impact of weather and climatic factors under two base scenarios of climate change (RCP4.5 and RCP8.5). They used the U.S. EPA environmental health risk assessment methodology basing on critical levels of substances in ambient air for plants, taking into account vegetation group and characteristic landscape or natural-climatic zone. Methodology for estimating the impurity concentration is based on solving the adjoint equation of impurity transfer and diffusion. Calculations have revealed that in most of the Russian Arctic over the past four decades, there has been a downward tendency in the hazard to plants from atmospheric pollution. In some areas, this tendency is significant (the north of the ETR and Western Siberia). A study of further trends in most of the Arctic zone showed insignificant risk dynamics, characterized, however, by some inter-scenario variability. Against the background of a milder climatic scenario (RCP4.5), some scatter in the direction of the hazard trend becomes noticeable in the Russian Arctic, but in general, a trend towards an increase in risk for plants can be noted.
Oceanic crust, transregional shear zones and the Amerasian microplate in the cretaceous-cenozoic geodynamics of ocean formation in the Arctic
Authors:   Polar Geophysical Institute of the Kola Scientific Center of RAS, Shipilov E.V.
Published: June 2023

The author has reconstructed the structural-tectonic setting of the Late Cretaceous-Early Cenozoic stage of the geodynamic evolution of the Arctic Ocean. It is shown that the oceanic crust in the Eurasian and Canadian basins occupies a much smaller area than previously thought and was formed in both on blocks of the continental basement strongly stretched by Cretaceous rifting. Due to the processes, large and extended transregional shear zones were set in motion: the Chukchi-Canadian during the opening of the Canadian basin in the Early Cretaceous, and the continental marginal ones — Khatanga-Lomonosov and Northern Greenland-Canadian, the activation of shear movements in which is associated with the Late Cretaceous-Paleocene time, when the consistent formation of the Makarov and Eurasian basins took place. As a result new composite Amerasian microplate was detached and set in motion, which combined the blocks of Arctic Alaska, the Canadian Basin, the Chukchi Rise, the Alpha–Mendeleev Rise, the Podvodnikov and Makarov Basins, and the Lomonosov Ridge. The movement of the microplate along approximately parallel large shear zones at the edges of the Canadian Arctic and Siberian-Chukotka shelves was directed towards the Pacific subduction zone. The movement of the Amerasian microplate was accompanied by rifting and detachment of the Lomonosov Ridge from the Barents-Kara margin, opening of the Eurasian Basin in the rear of the ridge, and transform displacements — right-sided along the Khatanga-Lomonosov zone and left-sided along the North Greenland-Canadian fault zone. At the same time, as a result of the movement of the Amerasian microplate, the previously unified area of Cretaceous plateau basalts (HALIP) was broken, and the Central Arctic province of magmatism was separated and moved away from the Barents Sea province.
Features of the geological structure of oil and gas fields in the east of the Siberian platform as a condition for improving the declarative principle of licensing in the Arctic zone
Authors:   М. К. Ammosov North-Eastern Federal University, Sivtsev A.I. , Ivanova T.S. ,   М. К. Ammosov North-Eastern Federal University
Published: June 2023

The article considers the distinctive features of the geological structure of oil and gas fields in the Republic of Sakha (Yakutia). A direct correlation has been established between the areas of oil and gas fields and their geological reserves. Based on a comparison of the geological structure of the territories, the authors conclude that for newly discovered oil and gas fields in the Arctic zone of the Republic of Sakha (Yakutia), such a correlation will persist. To enhance the investment attractiveness of the projects, the authors propose to increase the area of land plots provided on a declaration principle up to 2,000—3,000 km2.
Research on the acid decomposition kinetics of non-conventional titanium raw materials of the Arctic Zone of the Russian Federation
Authors:   Tananaev Institute of Chemistry - Subdivision of the Federal Research Centre «Kola Science Centre of the Russian Academy of Sciences», Mudruk N.V. , Antonov A.A. ,   Tananaev Institute of Chemistry - Subdivision of the Federal Research Centre «Kola Science Centre of the Russian Academy of Sciences», Nikolaev A.I. ,   Tananaev Institute of Chemistry - Subdivision of the Federal Research Centre «Kola Science Centre of the Russian Academy of Sciences», Rybalkina O.V. ,   Tananaev Institute of Chemistry - Subdivision of the Federal Research Centre «Kola Science Centre of the Russian Academy of Sciences»
Published: June 2023

Acid leaching kinetics of loparite, perovskite, and titanite concentrates by hydrochloric and nitric acids has been studied. Kinetic parameters of acid leaching have been calculated and fitted to several kinetic models. Deeply kinetic study gives us the knowledge of acid leaching of titanium-containing minerals, and parameters obtained allow us to choose the optimal conditions of the mineral processing.
Ice impact on the rockfill of port facilities
Authors:   Krylov State Research Centre, Dobrodeev A.A. , Sazonov K.E. ,   Krylov State Research Centre
Published: June 2023

The paper presents the experimental results of model tests in the ice tank of the Krylov State Research Center aimed at study the features of ice interaction with rockfill of hydraulic engineering structures. These rockfills are often used in port protective structures (dams, breakwaters, etc.). The main attention during the model tests was paid to the study of the rockfill influence on the total ice load, the process of ice heap formation in front of the structure, as well as the rockfill destruction under the ice impact. The experiments have shown that the horizontal component of the total ice load changes a little, while the vertical component noticeably decreases. It has been found that the rockfill displaces the ice formation towards the sea thus helps to protect the working surfaces of the hydraulic structure from ice impact. The tests have revealed that the rockfill of hydraulic structure can be destroyed by the drifting ice and identified two possible scenarios for this destruction. The results allow the authors to conclude about the rockfill for hydraulic structure designed for the Arctic.
Sosyal Kimlik İnşasında Damgalanmanın Rolü
Authors: Çaylak Melek
Published: June 2023

Toplumsal yaşam içerisindeki bireyler, konumları, beklentileri ve kimlik şekillenmesinin belirlenmesinde kendileri gibi olmayanlar tarafından oluşturulan bir sosyal kimlik inşası içerisinde kalmaktadırlar. Sosyal kimlik, toplum-birey ilişkisi bağlamında bireyin üyesi bulunduğu grup ve grubun toplumdaki diğer gruplarla ilişkileri çerçevesinde “kendi kimliğini” edinmesi sürecidir. Damgayı ise Goffman, “damgalanan bireye daha az değer verme davranışı, bu etiketi taşıyan insanların daha az istenebilir ve neredeyse insan gibi algılanmaması” olarak tarif etmektedir. Becker’a göre ise toplumsal gruplar, oluşturdukları kurallara uymayanları “dışarıdakiler” olarak etiketler ve sapmayı yaratırlar. Bu anlamda grup dışı olanlar yani normal olanlar dışındakiler damgalanmakta ve damgalananlar için daha çok olumsuz imaj oluşturulması ile sosyal kimlik edinimi negatif bir mana taşımaktadır. Bu kimlik inşasında en önemli tavır önyargılardır. Bu önyargılar sonucu toplumun damgalanan bireylere karşı tavır almasına, onları toplumdan dışlamasına, ayrımcılığa maruz kalmalarına, toplumsal aidiyet duygularının zayıflatmasına, toplumsal bütünleşmenin sağlanamamasına ve toplumda çatışma kültürünün oluşmasına kadar giden süreçlerin yaşanmasına sebep olmaktadır. Bu açıdan sosyal kimlik inşasında, gerçek ve görünen sosyal kimlik bağlamı irdelenerek, normallik ve anormalliğin vurgusu, ötekinin rolü ve damgalanmanın kişisel ve toplumsal söylemlerine değinilecektir.
Covid-19 İle Mücadelede Sosyal Belediyeciliğin Rolü
Authors: Karadeniz Yeliz
Published: June 2023

COVID-19 olarak bilinen pandemi ile, Mart 2020 tarihinden itibaren tüm dünya mücadele etmektedir. Covid-19 pandemisinin sosyal, siyasal, ekonomik ve psikolojik açıdan bireylere yansımaları da kaçınılmaz olmaktadır. Pandeminin tüm boyutları ile mücadelesi hükümetler, yerel yönetimler ve sivil toplum kuruluşları işbirliğiyle sürdürülmektedir. Dünya nüfusunun dağılımına bakıldığında çoğunluğun kentlerde yaşadığı görülmektedir. Bu yüzden kentsel alanda vatandaşlarla iç içe olan yerel yönetimlerin de bu salgınla mücadelede önemi artmaktadır. Küresel ölçekteki bu soruna en hızlı en pratik çözümlerin yerel yönetimler tarafından gerçekleştirilmesi beklenmektedir. Yerel yönetim denildiğinde akla ilk gelen nüfusun büyük bir kısmını barındıran belediyeler olmaktadır.
Bu çalışmada cevabı aranan başlıca soru; Dünyada ve Türkiye’de büyükşehir belediyelerinin salgınla mücadele sürecinde hangi hizmetlerle destek verdikleri olmuştur. Çalışmanın konusu, COVID-19’un etkisinde kalan ülkelerdeki ve Türkiye’de bulunan 30 büyükşehir belediyesinin yapmış olduğu hizmetlerdir. Bu doğrultuda çalışmanın amacı, tüm dünyada etkisi hala devam eden salgınla mücadelede belediyeler tarafından sunulan hizmetlerin araştırılması ve belediyelerin öneminin tartışılmasıdır.
Betimletici metodun uygulandığı çalışmada ulaşılan başlıca sonuç, merkezi idarenin yetişemediği alanlarda hızlı etki gösteren yerel yönetimlerin o boşluğu doldurduğudur. Türkiye’de belediyeler tarafından maske üretiminden, sosyal yardımlara, dijital araçlarla evde sosyal-kültürel faaliyetlere kadar yaratıcı hizmetlerin sunulduğu tespit edilmiştir.
The Possibility of Fidelity in Adaptations: The Case of Director Michael Haneke
Authors: Keleş Alper
Published: June 2023

This study seeks an answer to the question of whether the content of the novel or the interpretation of the novel content by a director is followed in film adaptations, how clear the boundaries of film narrative and literary narrative are, the reflections of the narrative techniques specific to these media in the two media, how effective the narrative features are at the level of the audience and the reader, and to what extent the audience is provided with the interpretation space allocated at the end of the films. The methodology used is determined by creating a common research area in both fields with the help of the concepts of cinema and literature, as emphasized in the theories of intermediality. This article, consisting of ideas specific to the fields of the two media, explains how searching for the literary text in adaptation films is an appropriate approach with the example of Michael Haneke's adaptation of Franz Kafka's The Castle.
Liriomyza sativae Blanchard, 1938 (Diptera: Agromyzidae)’nin DNA Barkodlaması
Authors: DAYAN Cem , YILDIRIM Eyüp Mennan
Published: June 2023

Bu çalışmada İncirliova ve Koçarlı ilçelerinde (Aydın) sebze alanlarından toplanmış Liriomyza sativae’ nin DNA barkodlaması 2020-2022 yılları arasında yapılmıştır. Morfolojik olarak tür teşhisi yapıldıktan sonra; örneklerin COI gen bölgesinin çoğaltılması için HCO/ LCO evrensel primerler kullanılmış ve 612 bç COI bölgesi elde edilmiştir. Örneklerin sekans analizi Triogen Biyoteknoloji (İstanbul-Türkiye) tarafından yapılmıştır. Örnekler NCBI’da bulunan BLAST aracılığıyla kontrol edildiğinde türlerin L. sativae (% 99-100) ve L. trifolii (%97-99) olduğu görülmüştür. Örnekler Genbank’a kaydedilmiştir. Çalışma sonucunda genetik çeşitlilik düşük bulunmuştur.
Le modèle du patient vertueux : un modèle doublement inverse
Authors: LAPLAUD Ambre
Published: June 2023

Le droit, en tant qu’ensemble normatif, est le témoignage ou l’expression d’une culture, de positionnements de groupes sociaux. Les valeurs ainsi véhiculées sont parfois « posées », c’est-à-dire qu’elles deviennent des normes sociales dont le législateur s’est inspiré. Appliqué à la santé, le modèle du patient vertueux n’a de cesse d’évoluer. D’abord en réaction aux revendications des associations de patients, le législateur a affirmé les droits fondamentaux des usagers du système de santé au cœur de la démocratie sanitaire. Cependant, ce modèle chimérique du patient autonome, ne peut être le reflet de la réalité en ce qu’il n’est pas transposable aux personnes vulnérables. D’autre part, en raison du système de sécurité sociale budgétairement contraint, le législateur tente d’orienter les comportements responsables, plus économes des ressources budgétaires en santé. Le modèle du patient vertueux est alors un patient dont l’autonomie est recherchée dans son parcours de vie et son pendant invoqué celui de sa responsabilisation. Cependant, il semble possible d’alimenter le capital vertueux du patient dans la relation de soins d’abord par la valorisation des savoirs expérientiels mais également par un usage raisonné du numérique pour que celui-ci soit un outil au service des usagers. Enfin, d’autres versions du modèle du patient vertueux devraient être esquissés par le législateur. En effet, afin de protéger le climat et les ressources naturelles, l’invocation des droits des générations futures trouverait ici un terreau fertile pour faire valoir leur droit à la protection de leur santé, y compris environnementale.
Una mirada hacia los trastornos psicológicos y los múltiples rostros del modelaje
Authors: Mercado Ibarra Santa Magdalena
Published: June 2023

México ocupa el quinto lugar en padecimientos de trastornos psicológicos en América Latina, lo cual representa una alta prevalencia; sin embargo, existe una baja proporción de personas que reciben tratamiento; esto cobra una peculiar importancia pues si bien el mundo del modelaje es un mundo externamente visibilizado, hay aristas que permanecen invisibles. Por ello el objetivo es analizar información científicamente sustentada sobre las realidades que enfrentan las modelos, con el fin de identificar de manera temprana los indicadores de riesgo psicopatológico contribuyendo a la concientización social. Es una investigación documental con información basada en la evidencia científica. Se encuentra que las modelos se enfrentan a exigencias extremas en cuanto a belleza y comportamiento, lo que puede llevarlas a recurrir a métodos perjudiciales para su salud por los estándares de la industria, que va derivando en el desencadenamiento de trastornos psicológicos diversos. El mundo globalizado, los medios de comunicación y las redes sociales perpetúan la idea de que solo la belleza idealizada es aceptable, generando presión para alcanzar esos estándares, afectando la autoestima, la salud física y mental. Sin embargo, se destaca la importancia del modelaje inclusivo como un avance en la industria, que entraña una ruptura de los estereotipos tradicionales, y que hoy día sigue siendo uno de los desafíos más fuertes, así como el fomentar una imagen de belleza más diversa y saludable.
Le modèle déconstruit dans l’histoire de l’art : Orlan face à Picasso
Authors: Doucet-Veyret Isabelle
Published: June 2023

Du 17 mai au 4 septembre 2022, Cécile Debray, directrice du Musée Picasso Paris a invité l’artiste plasticienne ORLAN pour une exposition appelée Les femmes qui pleurent sont en colère, exposition articulée autour de la série d’œuvres de Picasso, dont Dora Maar fut le modèle, connues sous le nom des Femmes qui pleurent, peintes et dessinées pendant la guerre civile espagnole. Il s’agira au regard d’une approche contemporaine post-#MeeToo de réinterroger le rapport de Picasso avec ses modèles et de poser comme question au-delà du rapport de Picasso avec Dora Maar, la place du modèle comme sujet et non plus comme seul objet. Dora Maar, elle-même photographe et peintre aurait été exclusivement fixée au statut de modèle de Picasso, réduite à un objet pleurant et subissant. Son œuvre pourtant essentielle aurait subi l’invisibilité propre à celles qui ont été les muses des « grands maîtres ». Après la très belle rétrospective Dora Maar L’œil ardent qui lui a été consacrée au Centre Pompidou du 5 juin au 25 juillet 2019, elle refait une apparition fracassante avec ORLAN qui s’empare des portraits des Femmes qui pleurent et réalise des photomontages à partir de collages numériques à l’esthétique et à la colère violente. Elle effectue des hybridations à partir d’éléments de son corps s’intégrant dans les portraits picassiens, déconstruisant et reconstruisant une nouvelle image propre à la subjectivité de notre époque et des nouveaux rapport Homme/ Femme.
Optimization of the diaminobenzidine substrate composition improves the performance of peroxidase-like Prussian Blue nanozymes in colorimetric assays
Authors: Khramtsov Pavel , Minin Artem , Galaeva Zarina , Mukhlynina Elena , Kropaneva Maria , Rayev Mikhail
Published: June 2023

One of the emerging trends in modern analytical and bioanalytical chemistry is the substitution of enzyme labels, such as horseradish peroxidase, with nanozymes — nanoparticles that possess enzyme-like catalytic activity. Since enzymes and nanozymes typically have different catalytic mechanisms, it is expected that the optimal reaction conditions will also differ. The objective of this paper was to optimize the diaminobenzidine (DAB) chromogenic substrate to enhance the performance of Prussian Blue nanozymes in immunostaining applications. We elucidated that enhancers (such as imidazole), which are typically added to commercial DAB substrate solutions to boost the color signal generated by peroxidase, can suppress the activity of nanozymes. This issue can be resolved by optimizing a nanozyme-specific substrate buffer composition. More specifically, we demonstrated that buffers such as citrate, MES, HEPES, and TRIS containing 1.5-2 M NaCl or NH4Cl substantially increase DAB oxidation by Prussian Blue and provide a higher signal than commercial DAB formulations. Moreover, the composition of the substrate solution (type of buffer, ionic strength, additives) affects signal intensity to the same degree as buffer pH. Tuning the substrate buffer composition is, therefore, a simple and efficient way of signal amplification in nanozyme-based assays. Optimized DAB substrate formulations were applied to Prussian Blue-based tissue staining, western blotting assay of immunoglobulins, and dot blot assay of antibodies against SARS-CoV-2.
Resolving coupled pH titrations using non-equilibrium free energy calculations
Authors: Wilson Carter J. , de Groot Bert L. , Gapsys Vytautas
Published: June 2023

In a protein, nearby titratable sites can be coupled: the (de)protonation of one may affect the other. The degree of this interaction depends on several factors and can influence the measured pKa. Here, we derive a formalism based on double free energy differences (ΔΔG) for quantifying the individual site pKa values of coupled residues. As ΔΔG values can be obtained by means of alchemical free energy calculations, the presented approach allows for a convenient estimation of coupled residue pKas in practice. We demonstrate that our approach and a previously proposed microscopic pKa formalism, can be combined with non-equilibrium (NEQ) alchemical free energy calculations to resolve pH-dependent protein pKa values. Toy models and both, regular and constant-pH molecular dynamics simulations, alongside experimental data, are used to validate this approach. Our results highlight the insights gleaned when coupling and microstate probabilities are analyzed and suggest extensions to more complex enzymatic contexts. Furthermore, we find that naïvely computed pKa values that ignore coupling, can be significantly improved when coupling is accounted for, in some cases reducing the error by half. In short, our results suggest that free energy methods can resolve the pKa values of both uncoupled and coupled residues.
How Orange Carotenoid Protein controls the excited state dynamics of Canthaxanthin
Authors: Arcidiacono Amanda , Accomasso Davide , Cupellini Lorenzo , Mennucci Benedetta
Published: June 2023

Orange Carotenoid Protein (OCP) is a ketocarotenoid-binding protein essential for photoprotection in cyanobacteria. The main steps of the photoactivated conversion which converts OCP from its resting state to the active one have been extensively investigated. However, the initial photochemical event in the ketocarotenoid which triggers the large structural changes finally leading to the active state is still not understood. Here we employ QM/MM surface hopping nonadiabatic dynamics to investigate the excited-state decay of canthaxanthin in OCP, both in the ultrafast S2 to S1 internal and the slower decay leading back to the ground state. For the former step we show the involvement of an additional excited state, which has been often named SX state, and we characterize its nature. For the latter step, we reveal an excited state decay characterized by multiple timescales, which are related to the ground-state conformational het- erogeneity of the carotenoid. We assigned the slowly decaying population to the so-called S∗ state.Finally, we identify a minor decay pathway involving the photoisomerization which could be the initial trigger to photoactivation of OCP.
Acetal Formation of Flavoring Agents with Propylene Glycol in E-cigarettes: Impacts on Indoor Partitioning and Thirdhand Exposure
Authors: Wu Shuang , Kim Erica , Zhao Ran
Published: June 2023

The widespread use of flavored e-cigarettes has led to a significant rise in teenage nicotine use. In e-liquids, the flavor carbonyls can form acetals with unknown chemical and toxicological properties. These acetals can cause adverse health effects on both smokers and non-smokers through thirdhand exposure. This study aims to explore the impacts of these acetals formed in e-cigarettes on indoor partitioning and thirdhand exposure. Specifically, the acetalization reactions of commonly-used flavor carbonyls in laboratory-made e-liquids were monitored using proton nuclear magnetic resonance (1H NMR) spectroscopy. EAS-E Suite and Poly-Parameter Linear Free Energy Relationships (ppLFERs) were employed to estimate the partitioning coefficients for species. Further, a chemical two-dimensional (2D) partitioning model was applied to visualize the indoor equilibrium partitioning and estimate the distribution of flavor carbonyls and their acetals in the gas phase, aerosol phase, and surface reservoirs. Our results demonstrate that a substantial fraction of carbonyls were converted into acetals in e-liquids, and their chemical partitioning was significantly influenced. This study shows that acetalization is a determinant factor in the exposure and toxicology of harmful carbonyl flavorings, with its impact extending to both direct exposure to smokers and involuntary exposure to non-smokers.
Prospects of Single-Cell NMR Spectroscopy with Quantum Sensors
Authors: Neuling Nick Ruben , Allert Robin Derek , Bucher Dominik Benjamin
Published: June 2023

Single-cell analysis can unravel functional heterogeneity within cell populations otherwise obscured by ensemble measurements. However, non-invasive techniques that probe chemical entities and their dynamics are still lacking. This challenge could be overcome by novel sensors based on nitrogen-vacancy (NV) centers in diamond, which enable nuclear magnetic resonance (NMR) spectroscopy on unprecedented sample volumes. In this perspective, we briefly introduce NV-based quantum sensing and review the progress made in microscale NV-NMR spectroscopy. Lastly, we discuss approaches to enhance the sensitivity of NV ensemble magnetometers to detect biologically relevant concentrations and provide a roadmap towards their application in single-cell analysis.
P-Band Intermediate States Mediate Electron Transfer at Confined Nanoscale
Authors: Zhang Kun , He Ming-Yuan
Published: June 2023

In this perspective article, mainly based on the model of structural water molecules (SWs) as bright color emitters, we briefly summarize the development and theoretical elaboration of P-band intermediate state (PBIS) theory and its application in catalysis, especially in several representative redox reactions. In particular, with a simple equation (2∫ψ2σ1’ + ∫ψ2σ2 + ∫ψ2π =1), we define how the interface sate correlate with the three basic parameters of heterogenous catalysis (conversion, selectivity and stability), and what is the dynamic nature of catalytic active sites. Overall, the proposal of SWs dominated PBIS theory provides new insights into the physical origin of photoluminescence emission of low-dimensional quantum nanodots and the physical nature of nanoconfinement and nanoconfined catalysis.
CGCompiler: Automated coarse-grained molecule parameterization via noise-resistant mixed-variable optimization
Authors: Stroh Kai S. , Souza Paulo C. T. , Monticelli Luca , Risselada H. Jelger
Published: June 2023

Coarse-grained force-fields (CG FF) such as the Martini model entail a predefined, fixed set of Lennard-Jones parameters (building blocks) to model virtually all possible non-bonded interactions between chemically relevant molecules. Owing to its universality and transferability, the building block coarse-grained approach has gained a tremendous popularity over the last decade. The parameterization of molecules can be highly complex and often involves the selection and fine tuning of a large number of parameters (e.g., bead types and bond lengths) to optimally match multiple relevant targets simultaneously. The parameterization of a molecule within the building block CG approach is a mixed-variable optimization problem: The non-bonded interactions are discrete variables whereas the bonded interactions are continuous variables. Here, we pioneer the utility of mixed-variable particle swarm optimization in automatically parameterizing molecules within the Martini 3 coarse-grained force-field by matching both structural (e.g., RDFs) as well as thermodynamic data (phase-transition temperatures). For sake of demonstration, we parameterize the linker of the lipid sphingomyelin. The important advantage of our approach is that both bonded- and non-bonded interactions are simultaneously optimized while conserving the search efficiency of vector guided particle swarm optimization (PSO) methods over other metaheuristic search methods such as genetic algorithms. In addition, we explore noise-mitigation strategies in matching the phase transition temperatures of lipid membranes, where nucleation and concomitant hysteresis introduces a dominant noise term within the objective function. We propose that noise-resistant mixed-variable PSO methods can both improve as well as automate parameterization of molecules within building block CG FFs, such as Martini.
Laboratory Evolution of Metalloid Reductase Substrate Specificity and Product Size
Authors: Hendricks Alexander , Cohen Rachel , McEwen Gavin , Tien Tony , Guilliams Bradley , Alspach Audrey , Snow Christopher , Ackerson Christopher
Published: June 2023

: Glutathione Reductase-Like Metalloid Reductase (GRLMR) is an enzyme that reduces selenodiglutathione (GS-Se-SG), forming zerovalent Se nanoparticles (SeNPs). Error prone polymerase chain reaction was used to create a library of ~10,000 GRLMR variants. The library was expressed in BL21 Escherichia coli in liquid culture with 50 mM of SeO32- present, under the hypothesis that the enzyme variants with improved GS-Se-SG reduction kinetics would emerge. The selection resulted in a GRLMR variant with 2 mutations. One of the mutations (D to E) lacks an obvious functional role, whereas the other mutation is L to H within 5 Å of the enzyme active site. This mutation places a second H residue within 5Å of an active site dicysteine. This GRLMR variant was characterized for NADPH dependent reduction of GS-Se-SG, GSSG, SeO32-, SeO42-, GS-Te-SG and TeO32-. The evolved enzyme demonstrated enhanced reduction of SeO32- and gained ability to reduce SeO42-. This variant is named Selenium Reductase (SeR) because of its emergent broad activity for a wide variety of Se substrates, whereas the parent enzyme was specific for GS-Se-SG. This study overall suggests that new biosynthetic routes are possible for inorganic nanomaterials using laboratory directed evolution methods.
Pesan Moral pada Lirik Lagu Kanjuruhan Karya Iwan Fals
Authors: Melati Inka Krisma , Iswatiningsih Daroe , Khikam Zahidi Mohammad
Published: June 2023

Pesan moral menjadi salah satu pesan yang sering disampaikan melalui lirik lagu. Masalah moral menjadi sangat penting untuk dikaji, karena banyaknya kasus yang berkaitan dengan rendahnya moral seseorang. Penelitian ini bertujuan untuk mengkaji (1) bentuk-bentuk pesan moral pada lirik lagu Kanjuruhan karya Iwan Fals, (2) makna pesan moral pada lirik lagu Kanjuruhan karya Iwan Fals, dan (3) konteks pesan moral pada lirik lagu Kanjuruhan karya Iwan Fals. Penelitian ini menggunakan metode penelitian bersifat deskriptif kualitatif. Sumber data penelitian yaitu lirik lagu Kanjuruhan karya Iwan Fals. Dta penelitian ini berupa kata, kalimat, baris, dan bait. Teknik pengumpulan data menggunakan teknik simak-catat. Teknik analisis data menggunakan analisis interpretasi teks. Hasil penelitian diperoleh simpulan bahwa (1)  ditemukan sebanyak 4 data terkait bentuk pesan moral hubungan manusia dengan Tuhan, ditemukan 3 data terkait bentuk pesan moral hubungan manusia dengan diri sendiri. Hubungan manusia dengan diri sendiri, dan ditemukan 2 data terkait bentuk pesan moral hubungan manusia dengan manusia lain. Selanjutnya, (2) makna pesan moral pada lirik lagu Kanjuruhan karya Iwan Fals. Makna pada pesan moral dianalisis berdasarkan dua jenis yaitu makna denitatif dan makna konotatit.  Makna konotatif adalah makna kias atau makna yang tidak sebenarnya. Makna denotatif pada lirik lagu Kanjuruhan karya Iwan Fals ditemukan sebanyak 15 data dan makna konotatif sebanyak 11 data. (3) Konteks pesan moral pada lirik lagu Kanjuruhan karya Iwan Fals adalah Tragedi Kanjuruhan pada tanggal 01 Oktober 2022.
A Non-Invasive Glucose Monitoring Device using NIR (Near Infra Red)
Authors:   Department of Biomedical Engineering,  Sri Venkateshwaraa college of Engineering and Technology, Ariyur, Puducherry, India, P Vanathi , R Monica ,   Department of Biomedical Engineering,  Sri Venkateshwaraa college of Engineering and Technology, Ariyur, Puducherry, India, J Prasanthi ,   Department of Biomedical Engineering,  Sri Venkateshwaraa college of Engineering and Technology, Ariyur, Puducherry, India, T Bavani ,   Department of Biomedical Engineering,  Sri Venkateshwaraa college of Engineering and Technology, Ariyur, Puducherry, India, T Logasundari ,   Assistant Professors, Department of Biomedical Engineering Sri Venkateshwaraa college of   Engineering and Technology,  Ariyur, Puducherry, India, A Kavinilavu ,   Assistant Professors, Department of Biomedical Engineering Sri Venkateshwaraa college of   Engineering and Technology,  Ariyur, Puducherry, India
Published: June 2023

In a developing country like India, systemic chronic diseases reach unsustainable heights as the population grows. According to WHO, diabetes affects an estimated 28.7 million people worldwide, or 28.5% of the population. Diabetes affects around 8.5 million people who have yet to be diagnosed (2022). Diabetes is one of these metabolic systemic chronic diseases that has captured the world's attention. The primary goal of our research is to develop non-invasive blood glucose monitoring technology that will benefit a large number of patients. We analyze the research progress and significant problems of non-invasive blood glucose detecting technologies in our project evaluation. In our study, we present an effective NIR-based optical detecting system. The existing non-invasive glucose monitoring device had a 60% accuracy level, however the proposed model will have an accuracy of 80% and will have a significant advantage over the existing system. Furthermore, the information is continuously delivered to the personal computer via serial communication via the UART protocol.