bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: LnV3Te3O15 (OH)3·nH2O (Ln: Ce, Pr, Nd, Sm, Eu, Gd; n = 1—2): A New Series of Semiconductors with Mixed‐Valent Tellurium (IV,VI) Oxoanions.
Authors: Lin Jian , Diefenbach Kariem , Fu Jingcheng , Cross Justin N. , Clark Ronald J. , Albrecht‐Schmitt Thomas E.
Published: October 2014

The new compounds LnV3Te3O15 (OH)3·nH2O (Ln: Ce, Pr, n = 2; Ln: Nd, Sm, Eu, Gd, n = 1) are hydrothermally synthesized from mixtures of Ln(NO3)3, TeO2, V2O3, and H2O (autoclave, 230 °C, 3 d).
ChemInform Abstract: Bi3Cr2.91O11: A Ferromagnetic Insulator from Cr4+/Cr5+ Mixing.
Authors: Yi Wei , Matsushita Yoshitaka , Sato Akira , Kosuda Kosuke , Yoshitake Michiko , Belik Alexei A.
Published: October 2014

The title compound is prepared by high pressure/high temperature reaction of stoichiometric mixtures of Bi2O3, CrO2, and CrO3 (Au capsules, 6 GPa, 1570 K, 2 h).
ChemInform Abstract: Ionothermal Syntheses and Optical Property of Chromium Selenidostannates Containing Linear Polyamine Ligand.
Authors: Lu Jia‐Lin , Tang Chun‐Ying , Wang Fang , Shen Ya‐Li , Yuan Ya‐Xian , Jia Ding‐Xian
Published: October 2014

The Cr‐containing selenidostannates (IV) and (V) are ionothermally synthesized and characterized by single crystal XRD and solid state optical diffuse reflectance spectroscopy.
ChemInform Abstract: High‐Temperature, High‐Pressure Hydrothermal Synthesis, Characterization, and Structural Relationships of Layered Uranyl Arsenates.
Authors: Liu Hsin‐Kuan , Ramachandran Eswaran , Chen Yi‐Hsin , Chang Wen‐Jung , Lii Kwang‐Hwa
Published: October 2014

The new uranyl arsenates (III), (V), (VI), (VIII), and (X) are characterized by single crystal XRD and photoluminescence spectroscopy.
ChemInform Abstract: Synthesis and Characterization of a New Open‐Framework Mixed‐Valence Aluminum—Iron Phosphate (C4H12N2)2 [Fe2Al5(PO4)8(H2O)].
Authors: Guo Yanan , Qiu Yuchen , Li Jiyang , Shao Lang , Song Xiaowei
Published: October 2014

The new title compound is hydrothermally synthesized from an aqueous mixture of FeCl2, Al(O‐iPr)3, H3PO4, (COOH)2, and piperazine as the structure‐directing agent (autoclave, 180 °C, 3 d).
ChemInform Abstract: Mukaiyama—Michael Reactions with trans‐2,5‐Diarylpyrrolidine Catalysts: Enantioselectivity Arises from Attractive Noncovalent Interactions, Not from Steric Hindrance.
Authors: Kemppainen Eeva K. , Sahoo Gokarneswar , Piisola Antti , Hamza Andrea , Kotai Bianka , Papai Imre , Pihko Petri M.
Published: October 2014

The 2,5‐diphenylpyrrolidine‐catalyzed enantioselective Mukaiyama—Michael reaction between substituted furans and enals is studied.
ChemInform Abstract: Direct Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated Butyrolactones to α,β‐Unsaturated Thioamides.
Authors: Yin Liang , Takada Hisashi , Lin Shaoquan , Kumagai Naoya , Shibasaki Masakatsu
Published: October 2014

The direct Cu‐catalyzed asymmetric addition of α,β‐unsaturated thioamides to γ‐crotonolactone, α‐angelica lactone, and their derivatives is developed.
ChemInform Abstract: Synthesis of Interesting β‐Nitrohydrazides Through a Thiourea Organocatalyzed Aza‐Michael Addition.
Authors: Alcaine Ana , Marques‐Lopez Eugenia , Herrera Raquel P.
Published: October 2014

An unprecedented and enantioselective approach to antimicrobial β‐nitrobenzoyl hydrazides is achieved by bifunctional thiourea catalyzed aza‐Michael addition of p‐nitrobenzoyl hydrazide to nitroalkenes.
ChemInform Abstract: Aqueous Organocatalyzed Aldol Reaction of Glyoxylic Acid for the Enantioselective Synthesis of α‐Hydroxy‐γ‐keto Acids.
Authors: Moles Fernando J. N. , Guillena Gabriela , Najera Carmen
Published: October 2014

Glyoxylic acid is used as an electrophile in the stereoselective aldol reactions with unfunctionalized cyclic and non‐cyclic ketones by using catalyst BPA.
ChemInform Abstract: Zinc‐Catalyzed [4 + 3] Cycloaddition with Concomitant Furan Annulation: Formation of Cyclohepta[b]furans.
Authors: Song Bo , Li Lian‐Hua , Song Xian‐Rong , Qiu Yi‐Feng , Zhong Mei‐Jin , Zhou Ping‐Xin , Liang Yong‐Min
Published: October 2014

For the first time, a convenient zinc‐promoted [4 + 3] cycloaddition of a carbonyl ene—ynes with simple dienes is achieved.
ChemInform Abstract: Benzannulation via Ruthenium‐Catalyzed Diol—Diene [4 + 2] Cycloaddition: One‐ and Two‐Directional Syntheses of Fluoranthenes and Acenes.
Authors: Geary Laina M. , Chen Te‐Yu , Montgomery T. Patrick , Krische Michael J.
Published: October 2014

A new benzannulation protocol is developed consisting of Ru‐catalyzed diol‐diene [4 + 2] cycloaddition and subsequent aromatization upon dehydration or deoxydehydration is developed to allow the synthesis of a diverse range of polycyclic arenes.
ChemInform Abstract: Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides.
Authors: Willand‐Charnley Rachel , Puffer Benjamin W. , Dussault Patrick H.
Published: October 2014

Reaction of in situ generated carbanions with dialkyl peroxides is demonstrated to proceed intramolecularly to yield cyclic ethers (II) and (IV).
ChemInform Abstract: Asymmetric Hydrogenation of Maleic Acid Diesters and Anhydrides.
Authors: Bernasconi Maurizio , Mueller Marc‐Andre , Pfaltz Andreas
Published: October 2014

The asymmetric hydrogenation of dimethyl maleates, some dimethyl fumarates as well as dimethyl maleate/fumarate mixtures are investigated using a novel Ir‐complex as catalyst.
ChemInform Abstract: Diastereoselective Hydroxymethylation of Cyclic N‐tert‐Butanesulfinylketimines Using Methoxymethanol as Formaldehyde Source.
Authors: Priede Martins , Kazak Mihail , Kalnins Toms , Shubin Kirill , Suna Edgars
Published: October 2014

A stable and easy‐to‐handle source of anhydrous monomeric formaldehyde is used.
ChemInform Abstract: Chemoselective Intermolecular α‐Arylation of Amides.
Authors: Peng Bo , Geerdink Danny , Fares Christophe , Maulide Nuno
Published: October 2014

A novel approach for the direct α‐arylation of unactivated secondary amides with sulfoxides is developed.
ChemInform Abstract: Palladium‐Catalyzed Hydroarylation, Hydroalkenylation, and Hydrobenzylation of Ynol Ethers with Organohalides: A Regio‐ and Stereoselective Entry to α,β‐ and β,β‐Disubstituted Alkenyl Ethers.
Authors: Cui Weijian , Yin Jing , Zheng Renwei , Cheng Cungui , Bai Yihui , Zhu Gangguo
Published: October 2014

The hydroarylation and hydroalkenylation result in new and efficient formation of α,β‐substituted enol ethers with high regio‐ and stereoselectivity.
ChemInform Abstract: An Approach for Rapid Increase in Molecular Complexity: Atom Economic Routes to Fused Polycyclic Ring Systems.
Authors: Trost Barry M. , Ehmke Veronika
Published: October 2014

An asymmetric Pd‐catalyzed [3 + 2] cycloaddition of alkynyl substituted trimethylenemethane donors is developed to allow the synthesis of highly functionalized cyclopentanes having three contiguous stereocenters.
ChemInform Abstract: Diels—Alder Reaction of Tropones with Arynes: Synthesis of Functionalized Benzobicyclo[3.2.2]nonatrienones.
Authors: Thangaraj Manikandan , Bhojgude Sachin Suresh , Bisht Rajesh H. , Gonnade Rajesh G. , Biju Akkattu T.
Published: October 2014

A new procedure for the mild, practical, and scalable Diels—Alder reaction of tropones with arynes is reported.
ChemInform Abstract: C—H Bond Functionalization with the Formation of a C—C Bond: A Free Radical Condensation Reaction Based on the Phthalimido‐N‐oxyl Radical.
Authors: Patil Shradha , Chen Liang , Tanko James M.
Published: October 2014

It is demonstrated that N‐allyloxyphthalimides (I) are useful substrates for free radical based allylation of hydrocarbons.
ChemInform Abstract: Potassium N‐Iodo p‐Toluenesulfonamide (TsNIK, Iodamine‐T): A New Reagent for the Oxidation of Hydrazones to Diazo Compounds.
Authors: Nicolle Simon M. , Moody Christopher J.
Published: October 2014

Performing the synthesis of diazo compounds (X) and (XI) in a one‐pot‐procedure starting from (I) or (IV), respectively, gives the corresponding products in similar to higher yields compared to the two step procedure via (II) and (III) or (V) and (VI), respectively.
ChemInform Abstract: Trapping of Azidocarbenium Ion: A Unique Route for Azide Synthesis.
Authors: Pramanik Suman , Ghorai Prasanta
Published: October 2014

Azidocarbenium ions, which are formed in the presence of a lewis acid from gem‐diazides, have been trapped by nucleophiles for the first time.
ChemInform Abstract: Rearrangements of Propargylic Esters Can Be Induced by Some Electrophiles.
Authors: Cikotiene Inga
Published: October 2014

The first example of electrophile‐induced rearrangement of propargylic esters without need of gold catalysis is reported.
ChemInform Abstract: An Isothiourea‐Catalyzed Asymmetric [2,3]‐Rearrangement of Allylic Ammonium Ylides.
Authors: West Thomas H. , Daniels David S. B. , Slawin Alexandra M. Z. , Smith Andrew D.
Published: October 2014

The title scalable reaction generates syn‐α‐amino acid derivatives from ammonium ylides with excellent diastereo‐ and enantioselectivity.
ChemInform Abstract: Efficient Palladium‐Catalyzed Aminocarbonylation of Aryl Iodides Using Palladium Nanoparticles Dispersed on Siliceous Mesocellular Foam.
Authors: Tinnis Fredrik , Verho Oscar , Gustafson Karl P. J. , Tai Cheuk‐Wai , Baeckvall Jan‐E. , Adolfsson Hans
Published: October 2014

A highly dispersed nanopalladium catalyst supported on siliceous mesocellular foam (MCF) is successfully applied as heterogeneous catalyst in aminocarbonylation reactions.
ChemInform Abstract: Chemoselective Palladium‐Catalyzed Cyanation of Alkenyl Halides.
Authors: Powell Kimberley J. , Han Li‐Chen , Sharma Pallavi , Moses John E.
Published: October 2014

Different alkenyl nitriles can be obtained with this straightforward access.
ChemInform Abstract: Methoxycarbonylation of Olefins Catalyzed by Palladium(II) Complexes Containing Naphthyl(diphenyl)phosphine Ligands.
Authors: Zolezzi Santiago , Moya Sergio A. , Valdebenito Gonzalo , Abarca Gabriel , Parada Jose , Aguirre Pedro
Published: October 2014

The best result is obtained for the conversion of styrene by using the palladium complex PNC.
ChemInform Abstract: Manganese(IV)‐Mediated Hydroperoxyarylation of Alkenes with Aryl Hydrazines and Dioxygen from Air.
Authors: Kindt Stephanie , Jasch Hannelore , Heinrich Markus R.
Published: October 2014

A new carbooxygenation‐type version of the Meerwein arylation is reported.
ChemInform Abstract: Carbon—Carbon Coupling Reactions Catalyzed by Supported Pd Porphyrins.
Authors: Bagheri Omid , Sadegh Faranak , Moghadam Majid , Tangestaninejad Shahram , Mirkhani Valiollah , Mohammadpoor‐Baltork Iraj , Safiri Mahsa
Published: October 2014

The shown Pd‐complex (PPC) is supported on Dowex and Amberlite ion‐exchange resins and is used in Heck and Suzuki cross coupling reactions.
ChemInform Abstract: Enantioselective Direct α‐Alkylation of Cyclic Ketones by Means of Photo‐Organocatalysis.
Authors: Arceo Elena , Bahamonde Ana , Bergonzini Giulia , Melchiorre Paolo
Published: October 2014

The reaction proceeds through an in situ generated chiral electron donor‐acceptor complex.
ChemInform Abstract: Syntheses and Applications of (Thio)Urea‐Containing Chiral Quaternary Ammonium Salt Catalysts.
Authors: Novacek Johanna , Waser Mario
Published: October 2014

The enantioselective α‐fluorination of β‐keto esters is optimized with respect to the chiral urea catalyst used.
ChemInform Abstract: The Concise Synthesis of Spiro‐Cyclopropane Compounds via the Dearomatization of Indole Derivatives.
Authors: Luo Jing , Wu Bo , Chen Mu‐Wang , Jiang Guo‐Fang , Zhou Yong‐Gui
Published: October 2014

A facile conversion of 3‐tosylmethyl functionalized N‐unsubstituted indoles to spirocyclic dearomatized products is developed using sulfonium salts as reagents under mild basic conditions.
ChemInform Abstract: Acylammonium Salts as Dienophiles in Diels—Alder/Lactonization Organocascades.
Authors: Abbasov Mikail E. , Hudson Brandi M. , Tantillo Dean J. , Romo Daniel
Published: October 2014

The acylammonium salts are generated in situ from the acid chlorides and the organocatalyst BTA and are transformed to cis‐ and trans fused bicyclic γ‐ and δ‐lactones with up to four contiguous stereocenters.
ChemInform Abstract: Asymmetric Isomerization of ω‐Hydroxy‐α,β‐Unsaturated Thioesters into β‐Mercaptolactones by a Bifunctional Aminothiourea Catalyst.
Authors: Fukata Yukihiro , Okamura Takaaki , Asano Keisuke , Matsubara Seijiro
Published: October 2014

This novel title reaction gives access to different substituted lactone derivatives in high yields and with reasonably high enantioselectivities.
ChemInform Abstract: C—H Activation by Amide Chelation Control: Ruthenium‐Catalyzed Direct Synthesis of 2‐Aryl‐3‐furanamides.
Authors: Zhao Yigang , Snieckus Victor
Published: October 2014

An efficient base‐free one‐step method is presented for the synthesis of heterobiaryls through highly regioselective directed C—H activation/arylation reaction of furan amides with aryl boroneopentylates.
ChemInform Abstract: Catalytic Asymmetric Bromoetherification and Desymmetrization of Olefinic 1,3‐Diols with C2‐Symmetric Sulfides.
Authors: Ke Zhihai , Tan Chong Kiat , Chen Feng , Yeung Ying‐Yeung
Published: October 2014

A dia‐ and enantioselective bromoetherification and desymmetrization of olefinic 1,3‐diols is developed using a chiral tetrahydrothieno[3,4‐d][1,3]dioxole as catalyst.
ChemInform Abstract: A Novel Efficient Protocol for Preparation of 3‐Formyl‐2‐arylbenzo[b]furan Derivatives.
Authors: Liao Benren , Ruan Libo , Shi Min , Li Nian , Chang Liang , Liu Leping , Yang Fan , Tang Jie
Published: October 2014

A convenient one‐pot two‐step protocol allows the conversion of substrate (I) into benzofuran derivatives via 3‐(dibromomethyl)‐2‐arylbenzo[b]furan intermediates.
ChemInform Abstract: Cooperative Effect in Organocatalytic Intramolecular Hydroamination of Unfunctionalized Olefins.
Authors: Wang Yu‐Mei , Li Ting‐Ting , Liu Gong‐Qing , Zhang Li , Duan Lili , Li Lin , Li Yue‐Ming
Published: October 2014

A variety of organic acids are tested for the hydroamination.
ChemInform Abstract: 1,6‐Enyne Cyclizations Catalyzed by N‐Heterocyclic Carbene Supported Gold Complexes: Deconvoluting Sterics and Electronics.
Authors: Arumugam Kuppuswamy , Varghese Bibin , Brantley Johnathan N. , Konda Sai S. M. , Lynch Vincent M. , Bielawski Christopher W.
Published: October 2014

Novel NHC‐gold complexes having cyclic diamide type structures are developed.
ChemInform Abstract: An Efficient Rhodium/Oxygen Catalytic System for Oxidative Heck Reaction of Indoles and Alkenes via C—H Functionalization.
Authors: Yang Lei , Zhang Guoying , Huang Hanmin
Published: October 2014

Optimized reaction conditions render possible the selective C‐2 alkylation of indoles.
ChemInform Abstract: Regioselective Synthesis of Indoles via Rhodium‐Catalyzed C—H Activation Directed by an in‐situ Generated Redox‐Neutral Group.
Authors: Muralirajan Krishnamoorthy , Cheng Chien‐Hong
Published: October 2014

The highly regioselective synthesis of unprotected indoles involves the reaction of the hydrochloride substrates with diethyl ketone to form hydrazones.
ChemInform Abstract: Cu(I)‐Catalyzed Tandem Decarboxylative/C—H Activation Coupling of Cyclic Diketones, Proline and Alkynes: Synthesis of α‐Alkynylated Pyrrolidine‐Oxyindoles.
Authors: Kumar Atul , Kumar Mukesh , Gupta Lalit Prakash , Gupta Maneesh Kumar
Published: October 2014

A variety of pyrrolidinyl oxyindoles are synthesized from one‐pot reaction of isatin derivatives [(I) and (V)], proline (II), and terminal alkynes with aromatic or ester substituents [(III) and (VII)].
ChemInform Abstract: Fe‐Catalyzed Novel Domino Isomerization/Cyclodehydration of Substituted 2‐[(Indoline‐3‐ylidene)(methyl)]benzaldehyde Derivatives: An Efficient Approach Toward Benzo[b]carbazole Derivatives.
Authors: Paul Kartick , Bera Krishnendu , Jalal Swapnadeep , Sarkar Soumen , Jana Umasish
Published: October 2014

The starting material is easily prepared from 2‐bromo‐N‐propargylanilides in high yields by Pd‐catalyzed domino Heck‐Suzuki coupling.
ChemInform Abstract: Copper‐Mediated Oxidative Transformation of N‐Allyl Enamine Carboxylates Toward Synthesis of Azaheterocycles.
Authors: Toh Kah Kah , Biswas Anup , Wang Yi‐Feng , Tan Yun Yun , Chiba Shunsuke
Published: October 2014

The synthesis of 3‐azabicyclo[3.1.0]hex‐2‐enes from N‐allyl enamine derivatives is developed.
ChemInform Abstract: Selective Palladium‐Catalyzed Direct C—H Arylation of Unsubstituted N‐Protected Pyrazoles.
Authors: Kumpulainen Esa T. T. , Pohjakallio Antti
Published: October 2014

Optimized conditions render possible the highly selective C‐5 arylation of pyrazole (I) with a wide variety of aryl bromides.
ChemInform Abstract: o‐Iodoxy Benzoic Acid—Mediated Synthesis of 3,5‐Diarylisoxazoles and Isoxazole‐3‐carboxylic Acids.
Authors: Desai Vidya G. , Naik Sneha R. , Dhumaskar Kashinath L.
Published: October 2014

via oxidative cyclization of α,β‐unsaturated ketoximes (I) or (III), resp., using IBX as efficient, environmentally friendly and nontoxic oxidation reagent
ChemInform Abstract: Ring Transformation of the S‐(2‐Oxo‐2,3‐dihydro‐1‐benzofuran‐3‐yl)isothiuronium Bromides to 5‐(2‐Hydroxyphenyl)‐2‐imino‐1,3‐thiazolidin‐4‐ones.
Authors: Hanusek Jiri , Kammel Richard
Published: October 2014

Isothiuronium bromides are prepared from commercially available 3‐bromobenzofuran‐2‐one and corresponding thioureas.
ChemInform Abstract: Supported CuBr on Graphene Oxide/Fe3O4: A Highly Efficient, Magnetically Separable Catalyst for the Multi‐Gram Scale Synthesis of 1,2,3‐Triazoles
Authors: Xiong Xingquan , Chen Huixin , Tang Zhongke , Jiang Yunbing
Published: October 2014

via one‐pot multicomponent azide‐alkyne 1,3‐dipolar cycloaddition reactions
ChemInform Abstract: An Efficient Synthesis of Conjugated 5‐Aryl‐1,3,4‐oxadiazoles from 3‐Heteroarylacrylohydrazides and Acid Chlorides.
Authors: Kudelko Agnieszka , Wroblowska Monika
Published: October 2014

A facile two step sequence allows the synthesis of oxadiazoles from hydrazides (I) or (V) and aromatic acid chlorides.
ChemInform Abstract: The Synthesis of Tetrazoles in Nanometer Aqueous Micelles at Room Temperature.
Authors: Xie Aming , Cao Meiping , Liu Yangyang , Feng Liandong , Hu Xinyu , Dong Wei
Published: October 2014

A newly developed nonionic amphiphile acts as an effective nanomicelle‐forming species for the synthesis of tetrazoles by 1,3‐dipolar cycloadditions under aqueous conditions.
ChemInform Abstract: Tandem N‐Alkylation/Vinylogous Aldol Reaction of β,γ‐Alkenyl α‐Iminoester.
Authors: Tanaka Hirotaka , Mizota Isao , Shimizu Makoto
Published: October 2014

This report describes a highly regioselective tandem N‐alkylation/vinylogous aldol reaction of β,γ‐alkenyl α‐iminoesters.
ChemInform Abstract: Rhodium(III)‐Catalyzed, C—H Activated Annulation to Form Isocoumarins and α‐Pyrones Using the O—N Bond as an Internal Oxidant.
Authors: Li Xing Guang , Liu Kai , Zou Gang , Liu Pei Nian
Published: October 2014

A mild, efficient, regioselective and redox‐neutral annulation of O‐benzoylhydroxylamines and internal alkynes is developed.
ChemInform Abstract: Sodium Acetate Catalyzed Multicomponent Approach to Medicinally Privileged 2‐Amino‐4H‐chromene Scaffold from Salicylaldehydes, Malononitrile and Cyanoacetates.
Authors: Elinson Michail N. , Ryzhkov Fedor V. , Nasybullin Ruslan F. , Zaimovskaya Tatiana A. , Egorov Mikhail P.
Published: October 2014

Alkyl (2‐amino‐3‐cyano‐4H‐chrome‐4‐yl)cyanoacetates are obtained as a mixture of two diastereoisomers.
ChemInform Abstract: Synthesis of Biscoumarin Derivatives Using Poly(4‐vinylpyridine)‐Supported Dual Acidic Ionic Liquid as a Heterogeneous Catalyst.
Authors: Parvanak Boroujeni Kaveh , Ghasemi Parvin , Rafienia Zahra
Published: October 2014

The main advantages of this methodology are high yields, short reaction times, simple work‐up procedure, easy preparation, handling and recycling of the catalyst.
ChemInform Abstract: Multi‐Walled Carbon Nanotube Supported Fe3O4NPs: An Efficient and Reusable Catalyst for the One‐Pot Synthesis of 4H‐Pyran Derivatives.
Authors: Fallah‐Shojaei Abdollah , Tabatabaeian Khalil , Shirini Farhad , Hejazi Seyyedeh Zoha
Published: October 2014

Several types of 4H‐pyran derivatives can be synthesized from 1,3‐diketones, malononitrile, and aromatic aldehydes.
ChemInform Abstract: A Photo‐Induced C—O Bond Formation Methodology to Construct Tetrahydroxanthones.
Authors: Xiao Zheming , Cai Shujun , Shi Yingbo , Yang Baochao , Gao Shuanhu
Published: October 2014

The title transformation is based on intramolecular trapping of the reactive species produced by photocatalytic activation of a C—Cl bond.
ChemInform Abstract: 3‐Formyltetramethylene Sulfone in the Fischer Reaction.
Authors: Tokmakov G. P. , Nam N. L.
Published: October 2014

Attempts to obtain thiopyranoindole derivatives directly by reaction of the title sulfone (I) with arylhydrazines stop at the hydrazone formation and require an additional acid‐mediated cyclization step.
ChemInform Abstract: New 4‐Pyridyl Nonaflates as Precursors for Push—Pull Solvatochromic Dyes.
Authors: Dominguez Moises , Reissig Hans‐Ulrich
Published: October 2014

New 2,6‐disubstituted 4‐pyridyl nonaflates (III) and (XI) are prepared which can be further converted to the direct precursors of push‐pull solvatochromic dyes via Suzuki‐Miyaura, Mizoroki‐Heck and Sonogashira reactions [cf.
ChemInform Abstract: Preparation of 2‐Aminopyridoimidazoles and 2‐Aminobenzimidazoles via Phosphorus Oxychloride‐Mediated Cyclization of Aminoureas.
Authors: Deasy Rebecca E. , Slattery Catherine N. , Maguire Anita R. , Kjell Douglas P. , Hawk Mai Khanh N. , Joo Jung Min , Gu Rui Lin , Moynihan Humphrey
Published: October 2014

The products are isolated as precipitates from the reaction mixture.
ChemInform Abstract: Synthesis of Novel Indolo[2,3‐c]quinolinones via Ugi‐4CR/Palladium‐Catalyzed Arylation.
Authors: Rasouli Mohammad Ali , Mahdavi Mohammad , Firoozpour Loghman , Shafiee Abbas , Foroumadi Alireza
Published: October 2014

A convenient two‐step procedure for the synthesis of the title species via four component Ugi reaction and intramolecular arylation of the resulting Ugi adducts is presented.
ChemInform Abstract: Fe3O4—CNTs Nanocomposites: A Novel and Excellent Catalyst in the Synthesis of Diarylpyrimidinones Using Grindstone Chemistry.
Authors: Safari Javad , Gandomi‐Ravandi Soheila
Published: October 2014

A green, tribochemical protocol for the synthesis of 4,6‐diarylpyrimidin‐2‐ones from aldehydes, acetophenone, and urea in a Bignelli‐type fashion under grinding conditions in the presence of Fe3O4/carbon nanotubes is established.
ChemInform Abstract: Solvatochromic Fluorescent 2‐Substituted 3‐Ethynyl Quinoxalines: Four‐Component Synthesis, Photophysical Properties, and Electronic Structure.
Authors: Gers Charlotte F. , Nordmann Jan , Kumru Ceyda , Frank Walter , Mueller Thomas J. J.
Published: October 2014

An improved and widely applicable method to prepare title quinoxalines is developed.
ChemInform Abstract: Redox‐Neutral α‐Oxygenation of Amines: Reaction Development and Elucidation of the Mechanism.
Authors: Richers Matthew T. , Breugst Martin , Platonova Alena Yu. , Ullrich Anja , Dieckmann Arne , Houk K. N. , Seidel Daniel
Published: October 2014

A direct condensation of salicylaldehydes and related ortho‐hydroxyarylketones with cyclic secondary amines offers an interesting regioselective synthesis of a variety of polycyclic N,O‐acetals.
ChemInform Abstract: Consecutive Reactions Between Methyl 3‐Dehydroshikimiate, Amines and 1,2‐Dichloroalkanes under Microwave Conditions: A Practical, One‐Pot Construction of N‐Substituted Dihydrobenzoxazines.
Authors: Zhang Ensheng , Xu Tianlong , Wang Dejian , Huang Tongkun , Yuan Mu , Li Jun , Zou Yong
Published: October 2014

Microwave promoted reaction of 3‐dehydroshikimate (I) with primary amines or the hydrazone (IV) and 1,2‐dichloroethane as bisnucleophile permits the efficient synthesis of 1,4‐benzoxazines.
ChemInform Abstract: A Facile One‐Pot Synthesis of Model Diethyl 6,6′‐Dioxotetrahydro‐5,5′‐bi(1,2,4‐triazine)‐5,5′‐dicarboxylates.
Authors: El‐Abadelah Mustafa M. , Mohammed Hanan H. , Abadleh Mohammed M. , Sabri Salim S. , Awwadi Firas F.
Published: October 2014

Diastereomeric, oxidative homo‐coupling of ethyl 6‐oxo‐1,2,4‐triazine‐5‐carboxylate is achieved in the absence of metals and radical trapper.
ChemInform Abstract: Gold‐Catalyzed 1,2‐Oxoarylations of Nitriles with Pyridine‐Derived Oxides.
Authors: Karad Somnath Narayan , Liu Rai‐Shung
Published: October 2014

The oxyarylation of ortho‐alkynyl substituted phenylacetonitriles with pyridine‐derived N‐oxides using a gold carbene complex as catalyst is developed.
ChemInform Abstract: Synthesis of Nitrogen‐Containing Benzoannulated Eight‐ and Nine‐Membered Heterocycles from Methyl 4‐Amino‐3‐iodobenzoate.
Authors: Hassam Mohammad , More Shivaji V. , Li Wen‐Shan
Published: October 2014

The title compounds (III) and (VI) are obtained using ring closing metathesis as the key step.
ChemInform Abstract: Borylation of Unactivated Aryl Chlorides under Mild Conditions by Using Diisopropylaminoborane as a Borylating Reagent.
Authors: Guerrand Helene D. S. , Marciasini Ludovic D. , Jousseaume Melissa , Vaultier Michel , Pucheault Mathieu
Published: October 2014

Palladium‐catalyzed coupling between aryl chlorides and diisopropylaminoborane leads to the formation of a C—B bond under mild conditions and in the presence of pinacol, the corresponding pinacol boronate esters are obtained in high yields.
ChemInform Abstract: Continuous‐Flow Synthesis of Trimethylsilylphenyl Perfluorosulfonate Benzyne Precursors.
Authors: Michel Boris , Greaney Michael F.
Published: October 2014

Continuous‐flow procedures are described for the synthesis of trimethylsilylphenols (II) as well as their direct continuous flow conversion to triflates (IV) and nonaflates (VI).
ChemInform Abstract: Mild Stereoselective Formation of Tri‐ and Tetrasubstituted Olefins by Regioselective Ring Opening of 1,1‐Disubstituted Vinyl Oxiranes with Dialkyl Dithiophosphates.
Authors: Guo Boying , Vitaku Edon , Njardarson Jon T.
Published: October 2014

In case of 1,1‐disubstituted substrates (I) the nucleophile adds exclusively at the terminal carbon to give predominantely Z‐products (III).
ChemInform Abstract: Convenient Synthesis of Triphenylphosphanylidene Spiro[cyclopentane‐1,3′‐indolines] and Spiro[cyclopent[2]ene‐1,3′‐indolines] via Three‐Component Reactions.
Authors: Han Ying , Sheng Yin‐Jian , Yan Chao‐Guo
Published: October 2014

A one‐pot three‐component reaction of isatylidene malononitriles or ethylisatylidene cyanoacetate with dimethyl acetylene dicarboxylate and triphenylphosphine is developed to yield spirocyclic adducts (IV).
ChemInform Abstract: Iridium‐Catalyzed Enantioselective C—H Alkylation of Ferrocenes with Alkenes Using Chiral Diene Ligands.
Authors: Shibata Takanori , Shizuno Tsubasa
Published: October 2014

A catalytic enantioselective CH‐alkylation of heteroaryl substituted ferrocenes with activated alkenes in the presence of an Ir‐complex and a bicyclic chiral diene as ligand is developed.
ChemInform Abstract: The First One‐Pot Synthesis of L‐7‐Iodotryptophan (IIIe) from 7‐Iodoindole and Serine, and an Improved Synthesis of Other L‐7‐Halotryptophans.
Authors: Smith Duncan R. M. , Willemse Tom , Gkotsi Danai S. , Schepens Wim , Maes Bert U. W. , Ballet Steven , Goss Rebecca J. M.
Published: October 2014

A bacterial cell lysate containing tryptophan synthase is developed to enable a scalable one‐pot biotransformation of indoles to the corresponding tryptophans with serine as coupling partner.
ChemInform Abstract: In(III) Triflate‐Mediated Solvent‐Free Synthesis and Activation of Thioglycosides by Ball Milling and Structural Analysis of Long Chain Alkyl Thioglycosides by TEM and Quantum Chemical Methods.
Authors: Kumar Vajinder , Taxak Nikhil , Jangir Ramniwas , Bharatam Prasad V. , Kartha K. P. Ravindranathan
Published: October 2014

Grinding of glycosyl acetates with aromatic and aliphatic thiols in the presence of In(OTf)3 is found to allow fast, diastereoselective, and highly efficient access to diverse thiosugars.
ChemInform Abstract: A New Ecdysteroidal Glycoside from Lepidogrammitis drymoglossoides (Bak.) Ching
Authors: Yao Jia‐Ning , Li Zhi‐Fu , Lou Hua‐Yong , Huang Lan , Liang Guang‐Yi , Cao Pei‐Xue , Pan Wei‐Dong
Published: October 2014

isolation, structure and cytotoxicity of the new steroidal glycoside ponasteroside B (I) along β‐ecdysterone
ChemInform Abstract: New Prenylated Indole Alkaloids from Fungus Penicillium sp. Derived of Mangrove Soil Sample.
Authors: Yang Bin , Dong Junde , Lin Xiuping , Zhou Xuefeng , Zhang Yanying , Liu Yonghong
Published: October 2014

The new indole alkaloids, mangrovamides A (I), B (II), and C (III) are isolated from the title fungus.
ChemInform Abstract: Taurospongins B and C, New Acetylenic Fatty Acid Derivatives Possessing a Taurine Amide Residue from a Marine Sponge of the Family Spongiidae.
Authors: Kubota Takaaki , Suzuki Haruna , Takahashi‐Nakaguchi Azusa , Fromont Jane , Gonoi Tohru , Kobayashi Jun'ichi
Published: October 2014

Taurospongins B (I) and C (II) were isolated from an Okinawan marine sponge of the family Spongiidae and their absolute configuration was established by a combination of spectroscopic analysis and synthetic chemistry.
ChemInform Abstract: Synthesis of 24(28)‐Methylene‐1α‐hydroxyvitamin D3, a Novel Vitamin D3 Analogue.
Authors: Guo Wei , Fang Zhijie , Li Hongliang , Liu Yanan
Published: October 2014

The novel vitamin D3 analogue (I) is prepared as raw material in 12% overall yield over 13 steps from vitamin D2.
ChemInform Abstract: One‐Step Semisynthesis Method of Spirocurcasone and Pyracurcasone from Curcusones A and B.
Authors: Li Xu‐Yang , Yang Yuan‐Feng , Peng Xing‐Rong , Li Ming‐Ming , Li Liang‐Qun , Deng Xu , Qin Hong‐Bo , Liu Jie‐Qing , Qiu Ming‐Hua
Published: October 2014

Spirocurcasone (II) and pyracurcasone (III) are prepared stereospecifically in one step from available curcusone.
ChemInform Abstract: Total Synthesis of Antifungal Gamahonolide A.
Authors: Sabitha Gowravaram , Reddy K. Purushotham , Reddy S. Purushotham , Yadav J. S.
Published: October 2014

The first stereoselective synthesis of the title compound is presented using aminoxylation, Keck allylation, and a metathesis reaction as key steps.
ChemInform Abstract: Three New anti‐Proliferative Annonaceous Acetogenins with Mono‐tetrahydrofuran Ring from Graviola Fruit (Annona muricata)
Authors: Sun Shi , Liu Jingchun , Kadouh Hoda , Sun Xiuxiu , Zhou Kequan
Published: October 2014

isolation, structure determination and antiproliferative activity of three novel acetogenins, muricins J, K and L
ChemInform Abstract: Syntheses of Cu2SnSe3 and Their Transformation into Cu2ZnSnSe4 Nanoparticles with Tunable Band Gap under Multibubble Sonoluminescence Conditions.
Authors: Park Jongpil , Lee Won Young , Hwang Cha Hwan , Kim Hanggeun , Kim Youngkwon , Shim Il‐Wun
Published: October 2014

Cu2SnSe3 nanoparticles are sonochemically synthesized under multibubble sonoluminescence conditions from mixtures of CuCl, SnCl2, and Se dissolved in a mixture of ethanolamine and ethylene glycol (ultrasound, 25 °C, 20 min, 78% yield).
ChemInform Abstract: Origin of Ferromagnetism in Co‐Implanted ZnO
Authors: Akdogan Numan , Zabel Hartmut
Published: October 2014

Review: 139 refs.
ChemInform Abstract: BaCeO3: Materials Development, Properties and Application
Authors: Medvedev D. , Murashkina A. , Pikalova E. , Demin A. , Podias A. , Tsiakaras P.
Published: October 2014

Review: 367 refs.
ChemInform Abstract: The YBaCo4O7+δ‐Based Functional Oxide Material Family: A Review
Authors: Parkkima Outi , Karppinen Maarit
Published: October 2014

Review: syntheses, structures, sorption behavior, magnetic properties; 118 refs.
ChemInform Abstract: Site Isolated Complexes of Late Transition Metals Grafted on Silica: Challenges and Chances for Synthesis and Catalysis
Authors: Rimoldi Martino , Mezzetti Antonio
Published: October 2014

Review: 183 refs.
ChemInform Abstract: Second‐Sphere Coordination Revisited
Authors: Liu Zhichang , Schneebeli Severin T. , Stoddart J. Fraser
Published: October 2014

Review: 58 refs.
ChemInform Abstract: Kinetically Controllable Supramolecular Polymerization Through Synchronized Activation of Monomers
Authors: Numata Munenori , Sakai Ryo‐ichiro
Published: October 2014

Review: [5 refs.
ChemInform Abstract: Microreactors for Peptide Synthesis: Looking Through the Eyes of Twenty First Century !!!
Authors: Ramesh Suhas , Cherkupally Prabhakar , de la Torre Beatriz G. , Govender Thavendran , Kruger Hendrik G. , Albericio Fernando
Published: October 2014

Review: 74 refs.
ChemInform Abstract: Structure, Biological Properties, and Total Synthesis of Polyhydroxylated Pyrrolizidines of the Hyacinthacines Family
Authors: Desvergnes Valerie , Landais Yannick
Published: October 2014

Review: 60 refs.
ChemInform Abstract: Recent Progress in the Synthesis of 2,6‐Disubstituted Hydroxypiperidine Alkaloids
Authors: Makabe Hidefumi
Published: October 2014

Review: 39 refs.
ChemInform Abstract: The Hasubanan and Acutumine Alkaloids
Authors: King Sandra M. , Herzon Seth B.
Published: October 2014

Review: 110 refs.
ChemInform Abstract: Marine Bi‐, Bis‐, and Trisindole Alkaloids
Authors: Veale Clinton G. L. , Davies‐Coleman Michael T.
Published: October 2014

Review: 143 refs.
ChemInform Abstract: The Methods for Obtaining 1‐(Perfluorobutyl)ethylene and Related Compounds
Authors: Barabanov V. G. , Zatcepina N. N. , Tupitsin I. F.
Published: October 2014

Review: 12 refs.
ChemInform Abstract: Chiral Fullerenes from Asymmetric Catalysis
Authors: Maroto Enrique E. , Izquierdo Marta , Reboredo Silvia , Marco‐Martinez Juan , Filippone Salvatore , Martin Nazario
Published: October 2014

Review: 46 refs.
ChemInform Abstract: Calix[4]pyrrole‐Based Ion Pair Receptors
Authors: Kim Sung Kuk , Sessler Jonathan L.
Published: October 2014

Review: 30 refs.
ChemInform Abstract: Transition‐Metal‐Catalyzed Asymmetric Allylic Dearomatization Reactions
Authors: Zhuo Chun‐Xiang , Zheng Chao , You Shu‐Li
Published: October 2014

Review: 72 refs.
ChemInform Abstract: Asymmetric Organocatalysis Combined with Metal Catalysis: Concept, Proof of Concept, and Beyond
Authors: Chen Dian‐Feng , Han Zhi‐Yong , Zhou Xiao‐Le , Gong Liu‐Zhu
Published: October 2014

Review: 74 refs.
ChemInform Abstract: Side Arm Strategy for Catalyst Design: Modifying Bisoxazolines for Remote Control of Enantioselection and Related
Authors: Liao Saihu , Sun Xiu‐Li , Tang Yong
Published: October 2014

Review: 63 refs.
ChemInform Abstract: Quantum Spin Ice: a Search for Gapless Quantum Spin Liquids in Pyrochlore Magnets
Authors: Gingras M. J. P. , McClarty P. A.
Published: October 2014

Review: 199 refs.
ChemInform Abstract: Future De Novo Drug Design
Authors: Schneider Gisbert
Published: October 2014

Review: 63 refs.
ChemInform Abstract: Preparation and Characterization of Activated Carbons Derived from Bio‐Solid: A Review
Authors: Ahmad A. A. , Idris A.
Published: October 2014

Review: 110 refs.
ChemInform Abstract: Lanthanide‐Organic Frameworks for Gas Storage and as Magneto‐Luminescent Materials
Authors: Roy Syamantak , Chakraborty Anindita , Maji Tapas Kumar
Published: October 2014

Review: 125 refs.
ChemInform Abstract: Properties of Circulating Fluidized Beds (CFB) Relevant to Combustion and Gasification Systems
Authors: Grace J. R. , Lim C. J.
Published: October 2014

Review: 83 refs.
ChemInform Abstract: Comparative Assessment of Managed Aquifer Recharge Versus Constructed Wetlands in Managing Chemical and Microbial Risks During Wastewater Reuse. A Review
Authors: Hamadeh A. F. , Sharma S. K. , Amy G.
Published: October 2014

Review: 29 refs.
ChemInform Abstract: Study of Solid Waste Management Programs in Shiraz‐Iran
Authors: Vaseghi Mohammad Rahim , Ramezannejad Amir
Published: October 2014

Review: 9 refs.
ChemInform Abstract: Synthesis, Characterization, and Computation of Catalysts at the Center for Atomic‐Level Catalyst Design
Authors: Spivey James J. , Krishna Katla Sai , Kumar Challa S. S. R. , Dooley Kerry M. , Flake John C. , Haber Louis H. , Xu Ye , Janik Michael J. , Sinnott Susan B. , Cheng Yu‐Ting , et al. et al.
Published: October 2014

Review: 229 refs.
Recent Developments in Dye‐Sensitized Solar Cells
Authors: Sharifi Nafiseh , Tajabadi Fariba , Taghavinia Nima
Published: October 2014

The knowledge of dye‐sensitized solar cells (DSCs) has expanded considerably in recent years. They are multiparameter and complex systems that work only if various parameters are tuned simultaneously. This makes it difficult to target to a single parameter to improve the efficiency. There is a wealth of knowledge concerning different DSC structures and characteristics. In this review, the present knowledge and recent achievements are surveyed with emphasis on the more promising cell materials and designs.
Controlling Molecular Conductance: Switching Off π Sites through Protonation
Authors: Schlicke Hendrik , Herrmann Carmen
Published: October 2014

Conductance switching through chemical modification of a molecular bridge is a major goal in molecular electronics, with the potential to lead to molecule‐based functional devices. In terms of switching speed, mechanisms that rely on only minor rearrangements of molecular structures are particularly promising. We demonstrate, based on density functional theory calculations combined with a coherent tunneling approach, how protonation and deprotonation of amine‐substituted or amine‐bridged model molecular wires can switch off and on π‐sites and thus: a) remove or introduce interference features in the electron transmission, and b) decrease or increase coupling along a chain. This mechanism may also be relevant for interactions between molecular bridges and metal cations, for example, in sensor applications.
Chaos control of uncertain time‐delay chaotic systems with input dead‐zone nonlinearity
Authors: Pai Ming‐Chang
Published: October 2014

This article presents an adaptive sliding mode control (SMC) scheme for the stabilization problem of uncertain time‐delay chaotic systems with input dead‐zone nonlinearity. The algorithm is based on SMC, adaptive control, and linear matrix inequality technique. Using Lyapunov stability theorem, the proposed control scheme guarantees the stability of overall closed‐loop uncertain time‐delay chaotic system with input dead‐zone nonlinearity. It is shown that the state trajectories converge to zero asymptotically in the presence of input dead‐zone nonlinearity, time‐delays, nonlinear real‐valued functions, parameter uncertainties, and external disturbances simultaneously. The selection of sliding surface and the design of control law are two important issues, which have been addressed. Moreover, the knowledge of upper bound of uncertainties is not required. The reaching phase and chattering phenomenon are eliminated. Simulation results demonstrate the effectiveness and robustness of the proposed scheme. © 2014 Wiley Periodicals, Inc. Complexity 21: 13–20, 2016
The “weight” of models and complexity
Authors: Du Jing
Published: October 2014

This article introduces a way of measuring the intrinsic complexity of models. Unlike complication, complexity is an irreducible indication of the innate characteristics of models. Instead of a reductionist paradigm, complexity should be measured in a holistic way. This article redefines the relationship between models and data, and proposes the concept of the “weight” of models, that is, how “heavy” a model is. Based on this concept, this article further defines the complexity of a model to be its ability to distort the space configuration. Three complexity indices are proposed to quantify the extent to which the input space is distorted by a model. It is recognized that there is a lack of widely accepted definition or measure of model complexity. The answer provided by this article is an attempt to move the inquiry a step closer to that goal. © 2014 Wiley Periodicals, Inc. Complexity 21: 21–35, 2016
Nanostructured Tungsten Trioxide Thin Films Synthesized for Photoelectrocatalytic Water Oxidation: A review
Authors: Zhu Tao , Chong Meng Nan , Chan Eng Seng
Published: October 2014

The recent developments of nanostructured WO3 thin films synthesized through the electrochemical route of electrochemical anodization and cathodic electrodeposition for the application in photoelectrochemical (PEC) water splitting are reviewed. The key fundamental reaction mechanisms of electrochemical anodization and cathodic electrodeposition methods for synthesizing nanostructured WO3 thin films are explained. In addition, the effects of metal oxide precursors, electrode substrates, applied potentials and current densities, and annealing temperatures on size, composition, and thickness of the electrochemically synthesized nanostructured WO3 thin films are elucidated in detail. Finally, a summary is given for the general evaluation practices used to calculate the energy conversion efficiency of nanostructured WO3 thin films and a recommendation is provided to standardize the presentation of research results in the field to allow for easy comparison of reported PEC efficiencies in the near future.
The key role of 13C NMR analysis in the identification of individual components of Polyalthia longifolia leaf oil
Authors: Ouattara Zana A. , Boti Jean Brice , Ahibo Antoine Coffy , Sutour Sylvain , Casanova Joseph , Tomi Félix , Bighelli Ange
Published: October 2014

Polyalthia longifolia produces sesquiterpene‐rich essential oils (EOs) whose compositions varied substantially from sample to sample depending on the origin of the plant (Nigeria and Vietnam). Nothing is known about the phytochemistry of Ivoirian P. longifolia. The aim of the present study was to characterize Ivoirian P. longifolia through the chemical composition of the leaf oil and to develop a strategy that allows the identification of minor oxygenated sesquiterpenes whose MS data are not compiled in commercial or laboratory‐constructed MS libraries. The EO was submitted to gas chromatography (GC) retention index (RI), GC‐mass spectrometry (MS) and 13C nuclear magnetic resonance (NMR) analysis. Then hydrocarbons and oxygenated components were separated and the oxygenated fraction was chromatographed on silica gel. The fractions were analysed by GC(RI) and 13C NMR. Seventy compounds accounting for 91.8% of the EO were identified. Sesquiterpene hydrocarbons, (E)‐β‐caryophyllene (27.8%), α‐zingiberene (20.0%) and allo‐aromadendrene (15.0%), were the major components. Various oxygenated sesquiterpenes whose MS data were not compiled in commercial and laboratory‐made MS libraries were identified by comparison of their chemical shift values in the spectrum of the fraction of CC with those reported in the literature and compiled in a laboratory‐constructed 13C NMR data library. The composition of the investigated Ivoirian P. longifolia oil sample presented similarities and differences with Nigerian and Vietnamese oils. Combined analysis of Ivoirian P. longifolia EO by chromatographic and spectroscopic techniques including 13C NMR without isolation of the components, appeared particularly efficient to identify minor components of EOs, whose MS spectra are insufficiently differentiated or MS data are not compiled in commercial and lab‐constructed MS libraries. Copyright © 2014 John Wiley & Sons, Ltd.
Neutrophil‐to‐Lymphocyte Ratio Positively Correlates to Age in Healthy Population
Authors: Li Jian , Chen Qingyu , Luo Xiaohong , Hong Jun , Pan Kunyi , Lin Xianghua , Liu Xiaoqiang , Zhou Lijun , Wang Han , Xu Ying , Li Hongyu , Duan Chaohui
Published: October 2014

Background

Neutrophil to lymphocyte ratio (NLR) was reported to be an independent easy‐to‐measure marker for many diseases, while the distribution of NLR in healthy population was not formally studied. So we investigated NLR in healthy people in this study.

Methods

Data include NLR, systolic pressure, diastolic pressure, and body mass index (BMI), which were collected from 3,262 healthy population. Correlations of NLR with variables were analyzed with SPSS16.0.

Results

Results demonstrated that NLR was positively associated with age (P < 0.001). The eldest age group possessed the highest NLR and the youngest age group had the lowest NLR. NLR was also slightly positively associated with systolic pressure, diastolic pressure, and BMI (P < 0.001).

Conclusion

Older people possessed relatively high NLR in healthy population.
Relationship of the Serum CRP Level With the Efficacy of Metformin in the Treatment of Type 2 Diabetes Mellitus: A Meta‐Analysis
Authors: Shi Lei , Tan Guang‐Shan , Zhang Kun
Published: October 2014

Background

Metformin, an anti‐diabetes drug, is always used as a first‐line agent for the management of T2DM. This meta‐analysis was conducted to investigate whether CRP was sensitive in predicting the efficacy of metformin in the treatment of T2DM.

Methods

Potential relevant studies were identified covering the following databases: MEDLINE, Science Citation Index database, the Cochrane Library Database, PubMed, EMBASE, CINAHL, Current Contents Index, the Chinese Biomedical Database, the Chinese Journal Full‐Text Database, and the Weipu Journal Database. Data from eligible studies were extracted and included into the meta‐analysis using a random effects model. Statistical analyses were calculated using the version 12.0 STATA software.

Results

A total of 33 articles including 1,433 subjects were collected for analysis. Pooled SMD of those studies revealed that serum levels of CRP and hs‐CRP significantly decreased in patients with T2DM after receiving the metformin treatment. Subgroup analysis by country yielded significant different estimates in the serum levels of CRP between the baseline and after metformin treatment in the China, Israel and India subgroups; but only detected only in the China subgroup considering serum levels of hs‐CRP. Follow‐up time‐stratified analyses indicated that serum levels of CRP were markedly reduced in the metformin‐treated group in all subgroups. While differences in serum hs‐CRP levels were not observed in two subgroups.

Conclusion

Decreased serum levels of CRP and hs‐CRP may contribute to a more sensitive prediction in providing a more accurate efficacy reference in the metformin drug in T2DM patients.
Diagnostic Value of Serum YKL‐40 Level for Coronary Artery Disease: A Meta‐Analysis
Authors: Song Chun‐Li , Bin‐Li   , Diao Hong‐Ying , Wang Jiang‐Hua , Shi Yong‐fei , Lu Yang , Wang Guan , Guo Zi‐Yuan , Li Yang‐Xue , Liu Jian‐Gen , Wang Jin‐Peng , Zhang Ji‐Chang , Zhao Zhuo , Liu Yi‐Hang , Li Ying , Cai Dan , Li Qian
Published: October 2014

Objective

This meta‐analysis aimed to identify the value of serum YKL‐40 level for the diagnosis of coronary artery disease (CAD).

Methods

Through searching the following electronic databases: the Cochrane Library Database (Issue 12, 2013), Web of Science (1945∼2013), PubMed (1966∼2013), CINAHL (1982∼2013), EMBASE (1980∼2013), and the Chinese Biomedical Database (CBM; 1982∼2013), related articles were determined without any language restrictions. STATA statistical software (Version 12.0, Stata Corporation, College Station, TX) was chosen to deal with statistical data. Standard mean difference (SMD) and its corresponding 95% confidence interval (95% CI) were calculated.

Results

Eleven clinical case‐control studies that recruited 1,175 CAD patients and 1,261 healthy controls were selected for statistical analysis. The main findings of our meta‐analysis showed that serum YKL‐40 level in CAD patients was significantly higher than that in control subjects (SMD = 2.79, 95% CI = 1.73∼3.85, P < 0.001). Ethnicity‐stratified analysis indicated a higher serum YKL‐40 level in CAD patients than control subjects among China, Korea, and Denmark populations (China: SMD = 2.97, 95% CI = 1.21∼4.74, P = 0.001; Korea: SMD = 0.66, 95% CI = 0.17∼1.15, P = 0.008; Denmark: SMD = 1.85, 95% CI = 1.42∼2.29, P < 0.001; respectively), but not in Turkey (SMD = 4.52, 95% CI = –2.87∼11.91, P = 0.231).

Conclusion

The present meta‐analysis suggests that an elevated serum YKL‐40 level may be used as a promising diagnostic tool for early identification of CAD.