bluuebunny/crossref_metadata_2025 huggingface dataset:
Kandungan Buah Delima (Punica granatum L.) dalam Perspektif Al-Qur'an, Sunnah, dan Sains
Authors: Mansur Sugeng Ali , Deroyeen Ahmad Fauzan , Indriyanti Muhfida Nur , Annisak Alif Kammaliyyah , Fajriati Devina Rizka , Amiruddin Muhammad
Published: March 2023

The pomegranate is one of the many fruits mentioned by Allah SWT. in the Koran. Namely Q.S. Al-An'am verse 99 and Q.S. Ar-Rahman verse 68, with the term Al-rumman (Arabic). The pomegranate is special because it is one of the fruits of heaven. And when viewed from the world of empirical science, it turns out that almost all parts of this plant benefit the human body's health. Some important ingredients in pomegranate, such as vitamin C, ellagitannin (tannin), triterpenoids, flavonoids, and alkaloids, can function as antioxidants, antibacterials, antidiabetics and prevent cancer cells. Writing this article is expected to be able to enrich the treasures of modern health, which tends to be left only in the medical world, in addition to being an enrichment of knowledge about pomegranates both from an Islamic and health (medical) point of view.
¡Seamos Conscientes, Mujeres! Nuestro Trabajo es Para Todos! Experiencias Vividas, Vidas Contadas de Trabajadoras de la Segunda República Española
Authors: Alexise Ikossié Seibo , Kouakou Véronique , País Andrade Marcela A.
Published: March 2023

El artículo propone exponer el modelo de mujer consciente como la que se responsabiliza de su emancipación a la luz de los beneficios otorgados a las mujeres durante la Segunda República por una legislación que introduce varios cambios sociales. Las leyes favorables a los obreros les benefician a veces y otras veces el peso del patriarcado les dificulta el beneficio de las ventajas. Para ello, analizamos cualitativamente tres de las características que se resignifican en este nuevo tipo de mujer en un contexto tensionado por las resistencias y negociaciones ante los cambios. Hemos presentado respectivamente la mujer en su controvertido empleo; la mujer casada y el beneficio de su empleo para el hogar; y el compromiso de la mujer hacia el vecindario, realizado con sus ganancias. Dimos cuenta que dichas féminas no se limitaron a defender la nación o a responsabilizarse de su emancipación sino que participaron activamente en el bienestar de su familia y de la comunidad: su toma de conciencia les llevó a realizar un trabajo remunerado para aliviar al marido en los gastos; controlar la reproducción para una mejor gestión de los gastos; y ayudar a varios necesitados, individual y colectivamente.

 

The article proposes to expose the model of the conscious woman as the one responsible for her emancipation, in the light of the benefits granted to women during the Second Republic through legislation that introduced various social changes. The laws in favor of workers sometimes benefit them, however, the patriarchal system makes it difficult for them to benefit from these advantages. To do this, we analyze qualitatively what are the characteristics that are resignified in this new type of woman in a context marked by the resistances and negotiations that preceded the changes. We have presented respectively the woman in her controversial job; the married woman and the benefit of her employment for the home; and the woman’s commitment to the neighborhood, made with her earnings. We found that these women did not only defend the nation or take responsibility for its emancipation, but also actively participated in the well-being of their family and community: their awareness led them to do paid work to relieve their husband's expenses, to control reproduction in order to better manage expenses, and to help several needy people, individually and collectively.
Religious-Nationalism Based Character Education ‎in Traditional Pesantren
Authors: Rahman Yulia
Published: March 2023

Penelitian ini dilatarbelakangi oleh maraknya tudingan radikalisasi melalui lembaga pendidikan Islam, khususnya pesantren tradisional. Proses pembelajaran di pesantren tradisional yang terkesan belum mampu melatih kemampuan berfikir kritis peserta didik dinilai sebagai faktor mudahnya radikalisme tumbuh di lembaga tersebut. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan pendidikan karakter berbasis nationalism-religius di Pesantren Tradisional. Fokus penelitian adalah pada pendidikan karakter nationalism-religius pada materi pembelajaran dan budaya pesantren. Jenis penelitian ini adalah penelitian mix method dengan teknik field research. Data-data dikumpulkan dengan teknik dokumentasi, wawancara dan angket. Adapun data angket merupakan data kuantitatif yang dianalisa dengan paradigma kualitatif. Data-data tersebut bersumber dari tiga pesantren tradisional di Kota Padang. Hasil penelitian ini menyimpulkan bahwa pendidikan karakter berbasis nationalism-religius di pesantren tradisional diterapkan dalam materi pembelajaran Akhlak yang mengacu pada kitab kuning dan buku paket mata pelajaran agama Islam. Selain itu pendidikan karakter nasionalis-religius juga dikembangkan melalui budaya pesantren yang kental dengan nilai cinta tanah air, persatuan, toleransi, dan demokratis. Kesimpulan ini didukung oleh sikap nasionalis-religius yang dimiliki oleh mayoritas santri di pesantren tradisional. Hasil penelitian ini menguatkan kesimpulan penelitian sebelumnya yang menyatakan bahwa pesantren mengajarkan sikap akomodatif, pluralis dan menolak paham radikal.
Strengthening Character Education for Gen Z ‎ in the Era of Disruption through a Personal-Constructive Sufi Approach
Authors: Saiful Islam  , Fauzi Muharom  , Fauzi Annur  , Arsyil Azwar Senja  , Kunti Zahrotun Alfi
Published: March 2023

This study aims to find out how educational institutions prepare strategies and concepts for their students in the current era of disruption, especially in strengthening character formation in Generation Z. An era that offers acceleration in various areas of life, one of them is acceleration in uprooting the established foundations of life. The research method used in this research is library research with an analytical descriptive approach. The results of this study are that education must be able to present linear strategies and concepts with the characteristics of the Z-generation. One of these concepts is through a personal-constructive approach in strengthening the character education of students, especially the Z-generation. This approach was carried out as the Sufis in ancient times tried to improve their morals in totality before God and humans, namely through self-awareness of their spiritual potential and concrete actions that focused on fundamental things such as repentance, patience, sincerity, etc.
Innovation Of Religious Moderation Education In Muhammadiyah 2 Senior High School Surabaya
Authors: Bina Prima Panggayuh  , Muzakki Akh , Asrohah Hanun , Rijal Akh. Syaiful
Published: March 2023

This study aims to find out the process and implications of the educational process of religious moderation, so that it can be used as an evaluation and as a basis for better education. The research method used in this research is qualitative and with a descriptive analytic approach. The results of this study show that innovation in religious moderation education is found in the principal's policies, curriculum, habituation programs, and activities outside of learning such as extracurricular activities, commemoration of Islamic holidays, and other religious activities by mainstreaming the principles of religious moderation, namely tawassuth, ta'adul, and tawazun.
Teknik Akrostik Sebagai Inovasi Pembelajaran Keterampilan Menulis Puisi Di Sekolah Dasar (Studi Literatur)
Authors: Julianto Indra Rasyid
Published: March 2023

Artikel ini memiliki tujuan untuk memberikan kemudahan pada pembelajaran keterampilan menulis puisi di sekolah dasar bagi para guru. Banyaknya anggapan bahwa pembelajaran keterampilan menulis puisi terbilang sulit dan membutuhkan proses yang panjang memberikan tantangan tersendiri bagi para guru dalam pengaplikasiannya. Penelitian ini menggunakan studi literatur dengan deskriptif kualitatif melalui beberapa literatur yang diperoleh berdasarkan kefokusan materi. Teknik akrostik merupakan teknik yang memberikan kemudahan dalam keterampilan menulis puisi karena menyasar pada awal huruf secara vertikal yang nantinya akan tersusun menjadi sebuah kalimat inti. Berdasarkan 10 hasil studi literatur yang diperoleh, teknik akrostik dapat membantu para guru dan siswa di sekolah dasar dalam pembelajaran keterampilan menulis puisi dengan signifikan. Pembelajaran puisi tidak hanya mengenai pembelajaran yang terpaku pada buku. Penggunaan teknik akrostik dapat menjadi alternatif yang memberikan efek kesenangan pada siswa sekolah dasar, karena menjadi wahana baru untuk mereka dalam bersastra. Terkhusus teknik akrostik menjadi sarana pengantar pembelajaran dalam menulis puisi yang efektif dan memudahkan ide kata-kata dalam pembuatan puisi.
Results of clinical validation of a new method of brachial plexus trunk distraction after neuroraphy
Authors: Bogov (jr.) A. A. , Akhtyamov I. F. , Danilov V. I. , Starostina I. G. , Khannanova I. G. , Bogov A. A.
Published: March 2023

The paper describes the results of clinical testing of an apparatus for dosed traction of brachial plexus trunks. It is shown that in the presence of a 5 cm diastasis, it is possible to connect the nerve fragments and perform neurorhaphy without tension by bringing the shoulder to the head and bring the shoulder to the physiological position two and a half months after the reconstructive surgery.
Treatment of a damaged brachial plexus with help of stromal vascular fraction cell from adipose tissue
Authors: Bogov (jr.) A. A. , Akhtyamov I. F. , Danilov V. I. , Starostina I. G. , Khannanova I. G. , Bogov A. A.
Published: March 2023

The aim of the study – to accelerate the repair of the damaged brachial plexus using cells of the stromal vascular fraction isolated from adipose tissue.

Materials and methods. The study was carried out in 62 patients using stromal-vascular fraction cells from adipose tissue and classical methods of treatment for brachial plexus injury. The effectiveness of regeneration was evaluated using electromyographic examination and positive recovery of motor and sensory function.

Results and discussion. Assessment of the results of surgical treatment with stromal vascular fraction cells from adipose tissue after brachial plexus neurolysis revealed the restoration of early M3-M5 and S3-S4 functions in 90 % of patients, and in the comparison group – 68 % respectively. The number of patients with M4-M5 functions in the group using the stromal vascular fraction for brachial plexus neurotization was 85 %, while in the control group it was 64 %, respectively. Electroneuromyography data also indicated an increase in the average number of motor units by 30 % after using cells of the stromal-vascular fraction from adipose tissue, in contrast to the comparison group.

Conclusion. Stromal vascular cells isolated from adipose tissue appear to be promising stimulants of brachial plexus injury repair.
Relationship between Adequacy Level of Nutritional Intake, Hydration Status, and Work Fatigue with Employee Productivity of PT. PAL Indonesia (Persero)
Authors: Arsanti Salsabila Meivitama , Farapti Farapti , Rachmah Qonita
Published: March 2023

Work productivity is a comparison between the results of work in the form of goods or services with the resources or labor used in a production process. The importance of adequate nutrition for general health and work productivity requires serious attention. The purpose of this study was to determine the relationship between the level of adequacy of nutrient intake, hydration status, and level of fatigue with work productivity. This study is an analytic observational study with a cross-sectional design. The research population is the general engineering division workers of PT. PAL Indonesia (Persero). The sample size calculated using Lemeshow formula was obtained as many as 64 respondents. Primary data sourced from questionnaires and interviews with respondents as well as secondary data on work productivity. Data were analyzed using Chi-Square analysis. The results showed that there was a relationship between energy intake (p=0.010) and worker productivity. Iron intake was also associated with worker productivity (p=0.024). But there are no relationship between work productivity with hydration status (p=0.272) and level of fatigue (p=0.556). There is a relationship between energy and iron intake with work productivity, but there is no relationship between hydration status and fatigue level with work productivity. Researchers suggest for workers to consume variety of type and amount of food intake daily.
Effect of Strawberry Powder Substitution on the Organoleptic of Instant Pudding
Authors: Srimiati Mia , Habibah Putri , Dinya Zahra Annisa , Harsanti Febry , Ratu Maharani Alfisa R
Published: March 2023

Strawberries are a nutrient-dense fresh fruit, but their use is restricted and they are quickly damaged due to their high water content. Therefore, innovation in strawberry processing is required so that the range of strawberry-processed goods is wider and has a longer shelf life, such as instant pudding. This study examined the effects of substituting strawberry powder to produce instant pudding with the highest nutritional and organoleptic qualities. The experimental design of the study includes four treatments, F1 (2%), F2 (4%), F3 (6%), F4 (8%), and F0, each of which contains a different dose of strawberry powder (control). The research was conducted at the Saraswati Indo Genetech laboratory in Bogor and the culinary and dietetics laboratory at Binawan University. Using Microsoft Excel 2019 and SPSS, the normality test (Kolmogorov Smirnov) and the Kruskal-Wallis test were applied to the organoleptic test results data. The results of the Kruskal Wallis test indicated a significant effect; the Mann-Whitney test was then conducted. The results revealed that instant pudding significantly altered color, flavor, texture, and odor. The most popular product is the F4 formulation, which contains 8% strawberry powder. The instant pudding has a water content of 75,62%, an ash content of 0,72%, protein content of 2,84%, a fat content of 1,25%, and carbohydrate content of 19,56%, according to an approximate analysis. It was impossible to determine the vitamin C content of the instant pudding because it was not recognizable.
La importancia de la mapificación de los ecosistemas y sus servicios para la planificación urbana = The importance of mapping ecosystems and ecosystem services in urban planning
Authors: Rafael Cordoba Hernández
Published: March 2023

ResumenLa investigación tiene como propósito analizar si planeamiento tiene la capacidad de protección y preservación del suelo para disminuir el riesgo generado por los impulsores directos del cambio detectados por la Evaluación de Ecosistemas del Milenio y valorar adecuadamente los bienes-servicio facilitados por los ecosistemas para mejorar la resiliencia del territorio frente a la crisis ambiental actual. Dependemos de ecosistemas saludables y resilientes para continuar brindando servicios, como alimentos, agua o aire limpio esenciales para nuestro bienestar. Por ello, contar con una descripción general sobre la situación actual de los ecosistemas y las presiones humanas a las que están expuestos es muy importante. En este marco se hace imprescindible la adecuada valoración de los ecosistemas, sus aportes, riesgos y poder territorializar estas cuestiones. Por ello es fundamental la cartografía, no solo del planeamiento sino también de todos aquellos elementos que de algún modo pueden proporcionar información al planificador para razonar la protección y preservación del suelo de cara a aumentar la resiliencia de ese territorio. Se analiza la evolución de la caracterización del territorio en base a las diferentes coberturas que cinco proyectos cartográficos europeos como son Biotopos CORINE, CORINE Land Cover, EUNIS, MAES y SIOSE desde el punto de vista ecosistémico.AbstractThe research aims to analyse whether planning has the capacity for soil protection and preservation to reduce the risk generated by the direct drivers of change identified by the Millennium Ecosystem Assessment and to value the ecosystem service goods provided by ecosystems to improve the resilience of the territory in the face of the current environmental crisis. We depend on healthy and resilient ecosystems to continue to provide services such as food, water or clean air that are essential for our well-being. Therefore, an overview of the current state of ecosystems and the human pressures to which they are exposed is especially important. Within this framework, it is essential to properly assess ecosystems, their contributions, risks and to be able to territorialise these issues. For this reason, mapping is fundamental, not only for planning but also for all those elements that in some way can provide information to the planner to reason the protection and preservation of the land with a view to increasing the resilience of that territory. The evolution of the characterisation of the territory is analysed based on the different coverages that five European mapping projects such as CORINE Biotopes, CORINE Land Cover, EUNIS, MAES and SIOSE from an ecosystemic point of view.
Réflexion participative pour une optimisation de l’usage d’antibiotiques garantissant santé et bien-être des porcs et volailles
Authors: BELLOC Catherine , GUENIN Marie-Jeanne , LEBLANC-MARIDOR Mily , HEMONIC Anne , ROUSSET Nathalie , CARRÉ Yannick , FACON Charles , LE COZ Philippe , MARGUERIE Jocelyn , PETIOT Jean-Marc , JARNOUX Maxime , PAUL Mathilde , MOLIA Sophie , DUCROT Christian
Published: March 2023

L'utilisation d'antibiotiques a diminué de près de 50 % dans les filières avicoles et porcines françaises en 15 ans. Cependant, cette évolution a été plus ou moins importante selon les élevages, et la mise en place de labels « sans antibiotiques » a pu se traduire dans certains cas par des excès de réduction d’usage des antibiotiques, au détriment de la santé et du bien-être des animaux.  Pour avancer dans la rationnalisation du recours aux antibiotiques, une démarche participative a été menée, associant des représentants des vétérinaires praticiens, des interprofessions porcine et avicole, des instituts techniques, du ministère de l’agriculture et des chercheurs. L’article présente les étapes majeures de la démarche et leurs résultats, concernant la vision à long terme partagée par le groupe sur l'utilisation des antibiotiques en élevage, et l’analyse des verrous à lever pour avancer vers l’objectif partagé. Les résultats montrent entre autres l'importance de la standardisation et de la diffusion de dispositifs de suivi, à l’échelle de la ferme, de la santé et du bien-être des animaux, de l'utilisation des antibiotiques et du niveau de résistance aux antibiotiques, afin de permettre aux éleveurs et vétérinaires de piloter avec précision l’usage des antibiotiques. Les deux autres champs d’action du collectif concernent i) le besoin d'une meilleure communication et information des consommateurs sur la question de la santé animale, du bien-être et du bon usage des antibiotiques et ii) la compétitivité économique de la filière et la viabilité économique des exploitations qui veulent investir en prévention.
Conceptions et pratiques de gestion de la santé des animaux en productions animales sous cahier des charges de l'agriculture biologiquebiologiques
Authors: BAREILLE Nathalie , DUVAL Julie , EXPERTON Catherine , FERCHAUD Stéphane , HELLEC Florence , MANOLI Claire
Published: March 2023

Afin de contribuer au développement continu de l’Agriculture Biologique (AB) en France, cet article apporte des éléments de compréhension de son cadre réglementaire et de ses particularités. Tout d’abord, l’analyse sociotechnique montre que les conceptions de la santé animale, portées par les éleveurs et les accompagnants techniques spécialisés, sont basés sur une approche préventive et holistique de la santé animale, selon laquelle la gestion de la santé passe avant tout par des leviers liés à la conduite du système d’élevage. Les éleveurs s’entourent d’une diversité d’acteurs pour les accompagner dans cette gestion globale de la santé, qui dépasse le conseil classique du vétérinaire. Ensuite, une autre particularité de la santé en élevage AB traitée ici est relative au statut épidémiologique des élevages : même si une forte variabilité existe entre élevages et pays, l’état sanitaire des troupeaux est en moyenne meilleur en AB qu’en agriculture conventionnelle. Enfin, un focus zootechnique est réalisé sur certaines pratiques d’élevage imposées ou recommandées par le cahier des charges pour des raisons de préservation de la santé ou de la biodiversité. Ces pratiques ont été largement adoptées par les éleveurs en AB et ont eu des impacts positifs sur la préservation de la santé des animaux. Ces particularités ont été traitées dans la littérature de façon inégale selon les filières. Des développements plus importants sont donc faits dans cette synthèse sur les espèces de Ruminants, et des apports plus ponctuels sur les productions porcines et avicoles.
Gender, Caste and Subjectivity: Revisiting the #MeToo Movement in India
Authors: Pan Anandita
Published: March 2023

The #MeToo movement has claimed to mark a ‘new era in Indian feminism’ by introducing feminist articulations into the quotidian through the powerful use of social media. The ‘sharing’ of survivor stories has served as a means to challenge the taboo of victimhood while also creating the possibility for solidarity. The #MeToo movement in India claims inheritance of previous movements such as the 2009 Pink Chaddi movement against moral policing, the 2011 Slut Walk movement against victim blaming, the 2015 Pinjra Tod movement against sexist curfew in hostels, and the 2017 Bekhauf Azadi. All these movements from which #MeToo claims heredity from, are movements proclaiming women’s right to access public space.

The article will delve into the positionality of the speaker; the role of intersectional identities of caste, class, and gender in determining subjecthood, and solidarity. In its focus on gender inequality and sexual violence, the #MeToo movement, ironically, reproduces casteist, classist and sexist hierarchies. What seems to drive the #MeToo movement in India is the anxiety regarding women’s confinement in the domestic sphere and the resultant inability to ‘speak’. This understanding categorically erases Dalit women, whose lives as well as oppression, encompass both private and public spaces. This article highlights the latent Brahmanism of the #MeToo movement by examining the erasure of Dalit women.
Sex-workers Defying Patriarchy and Challenging State Reform and Rehabilitation Projects in India: Voices from the Margins
Authors: Patnaik Shriya
Published: March 2023

Despite the prostitution industry being accorded a semi-legal status in India, the status of sex-workers remains abysmal with scarce provisions towards healthcare, education/literacy and/or labour rights. Consequently, the current approach to the rights of sex-workers is ridden with several structural barriers, as existing state reform projects often violate subjects’ bodily autonomy and act as moral discipliners, leaving them vulnerable to forms of systemic and institutionalised violence. Notwithstanding such exclusions, there have been strong feminist undercurrents advocating for the inclusion of such marginalised actors. One such example is the DURBAR NGO in Kolkata comprising of many sex-workers, calling for the legalisation of the prostitution industry as its underground nature enhances networks of crime, and simultaneous workers’ stigmatisation. DURBAR workers actively champion for their rights as equal citizens, and instead critique state regulation projects that seek to morally discipline them rather than providing concrete emancipation strategies or skill development. This article analyses such modalities of resistance through local channels of grassroots organisation, performative culture, and collective action. Reliant on such accounts from the margins, it elucidates how such bottom-up accounts of mobilisation, epitomise significant catalysts of agency and social change, which otherwise go missing from the dominant annals of policy and developmental discourses.
Transnationalising Dadis as Feminist Political/Activist Subjects
Authors: Gajjala Radhika , Edwards Emily Lynell , Rahut Debipreeta , Faniyi Ololade Margaret , Jha Bedadyuti , Jain Jhalak , Khan Aiman , Farooq Saadia
Published: March 2023

This article examines Twitter publics to map how the ‘dadis of Shaheen Bagh’ (grandmothers of Shaheen Bagh) emerged as political subjects through transnational media space even though they themselves did not directly access social media. A team of feminist media researchers examine how social media networks were mobilised strategically to gain international visibility and traction. Through a feminist close reading of Twitter data and a select few in-depth and unstructured interviews with various associated actors, this mediated visibility of seemingly subaltern women is mapped. This article draws on transnational/postcolonial feminist frameworks to examine digital public presences. This study uses a multi-methods approach that includes qualitative interviews with activists (local and transnational) and related actors as well as a situated feminist data analytics and critical digital humanities approach to examining big social data online. In examining the mediated production of this visibility, however, the study does not wish to imply that the women whose presence is amplified in international media are not actual protestors or to deny, discount or appropriate their agency or labour as activists.
Truth as Consistent Assertion
Authors: Rozycki Adam
Published: March 2023

This paper presents four key results in the philosophy of language. Firstly, it distinguishes between partial and consistent assertion of a sentence, and introduces the concept of an equivocal sentence, which is both partially asserted and partially denied. Secondly, it proposes a novel definition of truth, stating that a true sentence is one that is consistently asserted. This definition avoids the Liar paradox, does not restrict classical logic, and applies to declarative sentences in the language used by any particular person. Thirdly, the paper introduces an epistemic model of language, called assertional language, which formalizes the definition of truth. Finally, it provides an argument for the falsity of so-called Liar sentences. The proposed definition of truth can be viewed as a formal account of the correspondence theory. The epistemic model is a powerful concept that allows for combining different languages in a meaningful way. This model is uniquely capable of reflecting on epistemic inconsistencies, such as logical paradoxes, in a consistent manner and without resorting to non-classical solutions.
Enhanced Solid-State Fluorescence of Flavin Derivatives by In-Corporation in the Metal-Organic Frameworks MIL-53(Al) and MOF-5
Authors: Püschel Dietrich , Hédé Simon , Maisuls Ivan , Höfert Simon-Patrick , Woschko Dennis , Kühnemuth Ralf , Felekyan Suren , Seidel Claus A. M. , Czekelius Constantin , Weingart Oliver , Strassert Cristian A. , Janiak Christoph
Published: March 2023

The flavin derivatives 10‐methyl‐isoalloxazine (MIA) and 6-fluoro-10-methyl-isoalloxazine (6F-MIA) were encapsulated in two alternative metal-organic frameworks, (MOFs) MIL53(Al) and MOF5, using a post-synthetic, diffusion-based incorporation into microcrystalline MIL-53 powders and an in-situ approach during the MOF-5 synthesis. The flavin@MOF composites were analyzed by powder X-ray diffractometry (PXRD), N2-sorption studies and time-resolved fluorescence spectroscopy and microscopy. The maximum amount of flavin dye incorporation is 3.9 wt% for MIA@MIL-53(Al) and 1.5 wt% for 6F-MIA@MIL-53(Al), 0.85 wt% for MIA@MOF-5 and 27.6 wt% for 6F-MIA@MOF-5. The emission wavelengths of all flavin@MOF composites mostly correspond to the wavelengths of the flavins in solution. Time-resolved spectroscopy showed that the fluorescence lifetime of flavin@MOF of 2-4.7 ns also corresponds to those in solution but is significantly prolonged compared to the solid flavin dyes with less than 1 ns, thereby confirming the concept of "solid solutions" for dye@MOF composites. The fluorescence quantum yield (ΦF) of the flavin@MOF composites is about half of the solution but is significantly higher compared to the solid flavin dyes. Both the fluorescence lifetime and quantum yield of flavin@MOF decrease with the flavin loading in MIL-53. Theoretical calculations using plane-wave and QM/MM methods are in good correspondence with the experimental results and explain the electronic structures as well as the photoluminescence/photophysical properties of crystalline MIA and the flavin@MOF composites. In the solids flavins π-stacking interactions of the molecules lead to a charge transfer state with low oscillator strength resulting in aggregation-caused quenching (ACQ) with low lifetimes and quantum yields. In the MOF pores the flavin molecules are separated and the computed MIA@MOF structures do not find π-stacking interactions to the pore walls but only weak van-der-Waals contacts which reasons the enhanced fluorescence lifetime and quantum yield of the flavins in the composites compared to their neat solid state. The flexible MOF MIL-53(Al) was optimized essentially to the experimental large-pore form in the guest-free state with QuantumEspresso (QE) and with MIA molecules in the pores the structure contracted to close to the experimental narrow-pore form which was also confirmed by PXRD. In summary, the incorporation of flavins in MOFs yields solid-state materials with enhanced rigidity, stabilized conformation and reduced aggregations of the flavins, leading to increased fluorescence lifetime and quantum yield as controllable photo-luminescent and photo-physical properties.
Evaluation of the Child Criminal Justice System in the Perspective of Children with the Law
Authors: Suryawijaya Tito
Published: March 2023

The juvenile criminal justice system is an important part of maintaining justice and protecting children's rights in criminal cases. Through literature study techniques, this paper aims to evaluate the juvenile justice system in Indonesia from the perspective of children in conflict with the law. The results of the study show that there are still some deficiencies in the juvenile justice system, such as the low quality of legal services and the minimal participation of children in the judicial process. Some efforts that can be made to improve the juvenile justice system include improving the quality of legal services, providing greater opportunities for children to be involved in the judicial process, and increasing alternative dispute resolution outside of juvenile justice. It is hoped that the results of this research can make a positive contribution to improving the juvenile justice system in the future.
The Effect on HbA1c Levels of Age and Gender in Adults Without Diabetes Mellitus
Authors: Şener Gülşen , Kahvecioğlu Esra Deniz , Can Başak , Gümüş Alper , Yeşil Semih Beyazıt , Evran Betül
Published: March 2023

Objectives: Hemoglobin A1c (HbA1c) levels play an important role in the diagnosis, screening, and monitoring of treatment in diabetes. The aim of our study is to determine whether there is a relationship between HbA1c levels and age and gender in Turkish adults who have not been diagnosed with diabetes.Materials and Methods: This retrospective study included 6776 Turkish adults without diabetes. Cross-sectional analyzes of A1C levels were performed between different age and gender categories. In statistical analysis, t-test, linear regression analysis, one-way ANOVA analysis, and LSD post hoc were used.Results: HbA1c levels in the individuals examined by dividing into different age groups increased with age in all groups. In our study, HbA1c levels were significantly higher in males than females (p < 0.001) in all groups, especially between the ages of 30-49, and were positively associated with age for males and females. There was a positive correlation between HbA1c and age in both men and women aged 30-49 years (P < 0.05). In the HbA1c ≥ 6.5 group, HbA1c levels gradually decreased with age in both genders, and no significant effect of age on Hb1Ac level was detected (p > 0.05). Conclusion: Our results showed that it is important to evaluate the effects of age and gender when using HbA1c levels in the diagnosis, screening, and treatment of diabetes, especially in the young and middle-aged population. Applying this situation to daily practice may reduce the misdiagnosis of diabetes in elderly patients, overtreatment of diabetes, and its associated risks.K
Fecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease
Authors: Pekkala Satu
Published: March 2023

The frequency of non-alcoholic fatty liver disease (NAFLD) has exacerbated setting diagnostic challenges, which increases the need for reliable non-invasive diagnostic tools. Due to the importance of gut-liver axis in the progression of NAFLD, studies try to reveal microbial signatures in NAFLD, evaluate them as diagnostic biomarkers and to predict the disease progression. The gut microbiome affects human physiology by processing the ingested food to bioactive metabolites. These molecules can penetrate the portal vein and the liver to promote or prevent hepatic fat accumulation. Here findings of human fecal metagenomic and metabolomic studies in relation to NAFLD are reviewed. The studies present mostly distinct and even contradictory findings on microbial metabolites and functional genes in NAFLD. The most reproducing microbial biomarkers are increased lipopolysaccharides and peptidoglycan biosynthesis, enhanced degradation of lysine, increased levels of branched chain amino acids as well as altered lipid and carbohydrate metabolism. Among other causes, the discrepancies between the studies may be related to the obesity status of the patients and severity of NAFLD. In none of the studies except one, diet was considered, though it is an important factor driving the gut microbiota metabolism. The future studies should consider diet in the analyses.
Perioperative Essential Amino Acid Supplementation Facilitates Quadriceps Muscle Strength and Volume Recovery After TKA
Authors: Ueyama Hideki , Kanemoto Narihiro , Minoda Yukihide , Taniguchi Yoshiki , Nakamura Hiroaki
Published: March 2023

Background:

Perioperative essential amino acid (EAA) supplementation suppresses lower-limb muscle atrophy and promotes functional improvement in the first 4 weeks after total knee arthroplasty (TKA). However, its effect on the recovery of muscle volume and strength in the intermediate term is unclear. The aim of this study was to evaluate the effect of perioperative EAA supplementation on the recovery of lower-limb muscle volume and strength in the 2 years after TKA.

Methods:

Sixty patients who underwent unilateral TKA for primary knee osteoarthritis were included in this double-blinded randomized controlled trial. After excluding dropouts, 26 patients assigned to the EAA group (9 g/day) and 26 assigned to the placebo group (powdered lactose, 9 g/day) were available for analysis. Patients received EAA supplementation or a placebo from 1 week prior to surgery to 2 weeks after it. The rectus femoris muscle area was measured using ultrasonography and quadriceps muscle strength was measured isometrically with a handheld dynamometer, preoperatively and periodically up to 2 years postoperatively. Knee pain, knee range of motion, functional mobility, and Knee Society Score 2011 subjective scores were measured at each time point. Perioperative management, except for supplementation, was identical in the 2 groups.

Results:

Taking the baseline as 100%, the mean values in the EAA and placebo groups were 134% ± 31% and 114% ± 27%, respectively, for the rectus femoris muscle area and 159% ± 54% and 125% ± 40% for the quadriceps muscle strength, respectively, at 2 years after surgery. The differences were significant (p < 0.05). Clinical outcomes were not significantly different between the 2 groups.

Conclusions:

Perioperative EAA supplementation contributes to the recovery of rectus femoris muscle volume and quadriceps muscle strength in the 2 years after TKA. The EAA supplementation did not impact clinical outcomes.

Level of Evidence:

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Topological Structures on Vertex Set of Digraphs
Authors: Lalithambigai K. , Gnanachandra P.
Published: March 2023

Relation on a set is a simple mathematical model to which many real-life data can be connected. A binary relation  on a set  can always be represented by a digraph. Topology on a set  can be generated by binary relations on the set . In this direction, the study will consider different classical categories of topological spaces whose topology is defined by the binary relations adjacency and reachability on the vertex set of a directed graph. This paper analyses some properties of these topologies and studies the properties of closure and interior of the vertex set of subgraphs of a digraph. Further, some applications of topology generated by digraphs in the study of biological systems are cited.
Design of Stacked Multilayer Aperture Coupled Millimeter-wave Circular Array Antenna for 5G Femtobase stations
Authors: V Harini , S Sairam M V , R Madhu
Published: March 2023

In this paper, a design of a stacked multilayer aperture coupled millimeter-wave circular array antenna is proposed for 5G Femto base stations. As these base stations include miniature antennas where compact microstrip antennas with good impedance matching, high gain, and efficiency along with the reduction in sidelobe level which is the major advantage with aperture coupled feed mechanism. This array antenna exhibits low return loss at multiple frequency bands like 28GHz and 38GHz with reflection coefficient values like -18.74dB and -10.6dB including almost 100% radiation efficiency and attained maximum gain values like 11.93dBi and 10.44dBi. The proposed antenna achieves a sidelobe level value of 14dB at 28GHz in E-plane with wide beam widths of 80 0 and 85 0 at 28GHz and 38GHz respectively. There is a good agreement between simulated and measured results for the proposed aperture coupled millimeter-wave circular array antenna
An Intelligent Node Localization Algorithm for Heterogeneous Wireless Sensor Network Based Object Detection and Tracking System
Authors: Dev Jayashree , Mishra Jibitesh
Published: March 2023

Node localization is the process of determining the location of sensor nodes in the area of operation. To determine the location of the moving object in a heterogeneous wireless sensor network accurately, it is important to know the location of sensor nodes that sense the presence of the object in their vicinity area. Sensor nodes equipped with GPS facility can know their exact location with reference to some point in space. But this makes the network system expensive. So, alternate method of determination of exact location of the nodes are always inevitable. But unfortunately, no such error free method is proposed till date. Hence, it is an open research problem for the researchers. In this paper, we propose an intelligent algorithm based on swarm intelligence for node localization problem. The proposed algorithm is a hybrid swarm intelligence algorithm in which the location estimation error resulted in DV-Hop algorithm is corrected using hybrid Particle Swarm Optimization (PSO)-Grey Wolf Optimization (GWO) algorithm with Poor-for-Change strategy. The performance of the algorithm is evaluated and compared with existing DV-Hop using PSO and GWO based node localization algorithm. It is found that the object localization error is less in case of proposed model in comparison to the above said models.
Neutralization of IFNγ improves the safety profile of CAR T-cells while maintaining unaffected efficacy against B-cell malignancies
Authors: Manni Simona , Bufalo Francesca Del , Merli Pietro , Silvestris Domenico Alessandro , Guercio Marika , Caruso Simona , Reddel Sofia , Iaffaldano Laura , Pezzella Michele , Cecca Stefano Di , Sinibaldi Matilde , Ottaviani Alessio , Quadraccia Maria Cecilia , Aurigemma Mariasole , Sarcinelli Andrea , Ciccone Roselia , Abbaszadeh Zeinab , Ceccarelli Manuela , De Vito Rita , Lodi Maria Chiara , Cefalo Maria Giuseppina , Mastronuzzi Angela , De Angelis Biagio , Locatelli Franco , Quintarelli Concetta
Published: March 2023

Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary approach to induce long-lasting remission in patients with B-cell malignancies not responding to conventional therapies. Nevertheless, possible severe side effects, including cytokine release syndrome (CRS), neurotoxicity and macrophage activation syndrome, whose management is still challenging, as well as lack of pathophysiological experimental models to investigate novel interventions, limit the widespread use of this therapy. In light of these considerations, we developed a comprehensive humanized mouse model to investigate the role of IFNγ neutralization, provided by the clinically approved monoclonal antibody, emapalumab, in controlling severe toxicity related to CAR T cells. We demonstrated that emapalumab reduces the pro-inflammatory environment in the animal model, allowing severe CRS control and preventing brain damage, characterized by multifocal hemorrhages. Furthermore, we proved that IFNγ inhibition does not affect the ability of CAR.CD19 T cells to eradicate CD19+ lymphoma cells, both in vitro and in vivo.
Feasibility and acceptability of ‘Low Intensity mental health Support via a Telehealth Enabled Network’ for adults with type 1 and type 2 diabetes: the LISTEN pilot study
Authors: Holloway Edith , Gray Shikha , Halliday Jennifer , Hines Carolyn , Skinner Timothy C , Speight Jane , Hendrieckx Christel
Published: March 2023

Background
This study examined the feasibility and acceptability of the Low Intensity mental health Support via Telehealth Enabled Network (LISTEN) intervention, for adults with diabetes, facilitated by diabetes health professionals (HPs).
Methods
LISTEN training. Three HPs participated in three half-day online workshops, and applied their learnings during training cases (maximum four). Competency was assessed with a validated tool and achieving ‘satisfactory’ ratings for three consecutive sessions. LISTEN pilot. A single-group, pre-post study (up to four LISTEN sessions) with online assessments at baseline, post-intervention, and 4-week follow-up. Eligible participants were adults with type 1 or type 2 diabetes, with diabetes distress, but excluded if they had moderate/severe depressive and/or anxiety symptoms. Feasibility was assessed via recruitment and session completion rates. Acceptability was assessed with post-intervention self-report data. Changes in diabetes distress and general emotional well-being from baseline (T1) were explored at post-intervention (T2) and at 4-week follow-up (T3).
Results
Two HPs achieved competency (median training case sessions required: 7) and progressed to deliver LISTEN in the pilot study. In the pilot, N = 16 adults (Med[IQR] age: 60 [37–73] years; 13 women) with diabetes participated (median sessions per participant: 2). Twelve participants (75%) completed the post-intervention assessment (T2): 92% endorsed the number of sessions offered as ‘just right’, 75% felt comfortable talking with the HP, and 67% were satisfied with LISTEN. Perceived limitations were the structured format and narrow scope of problems addressed. Diabetes distress scores were lower post-intervention.
Conclusions
This pilot demonstrates the feasibility of training HPs to deliver LISTEN; and the acceptability and potential benefits of LISTEN for adults with diabetes. The findings highlight adaptations that may enhance delivery of, and satisfaction with, LISTEN that will be tested in a hybrid type 1 effectiveness-implementation trial.
Deep electron cloud-activity and field-activity relationships
Authors: Xu Lu , Yang Qin
Published: March 2023

Chemists have been pursuing the general mathematical laws to explain and predict
molecular properties for a long time. However, most of the traditional quantitative
structure-activity relationship (QSAR) models have limited application domains, e.g.,
they tend to have poor generalization performance when applied to molecules with
parent structures different from those of the trained molecules. This paper attempts to
develop a new QSAR method that could theoretically predict various properties of
molecules with diverse structures. The proposed deep electron cloud-activity
relationships (DECAR) and deep field-activity relationships (DFAR) methods consist
of three essentials: (1) A large number of molecule entities with activity data as
training objects and responses; (2) three-dimensional electron cloud density (ECD) or
related field data by the accurate density functional theory methods as input
descriptors; (3) a deep learning model that is sufficiently flexible and powerful to
learn the large data described above. DECAR and DFAR are used to distinguish 977
sweet and 1965 non-sweet molecules (with 6-fold data augmentation) and the
classification performance is demonstrated to be significantly better than the
traditional least squares support vector machine (LS-SVM) models using traditional
descriptors. DECAR and DFAR would provide a feasible and promising way to
establish a widely applicable, cumulative, and shareable artificial intelligence-driven
QSAR system. They will promote the development of an interactive platform to
collect and share the accurate ECD and field data of millions of molecules with
annotated activities. With enough input data, we envision the appearance of hundreds
of deep networks trained for various molecular activities. Finally, we could anticipate
a single DECAR or DFAR network to learn and infer various properties of interest for
chemical molecules, which will become an open and shared learning and inference
tool for chemists.
The use of digital technologies in the promotion of health literacy and the empowerment of the Informal Caregiver: a scoping review
Authors: Soares Suzete , Hoffmeister Louíse Viecili , Fernandes Maria de Fátima , Henriques Adriana , Câmara Gisele , Costa Andreia Silva da
Published: March 2023

Background: Informal Caregivers (ICs) play an important role in the community as healthcare providers to people who are dependent. Health literacy contributes to empowering care and self-management of one’s own health and can be enhanced by using digital technologies.
Aim: To map scientific evidence about the use of digital technologies to promote health literacy and the empower the IC.
Method: A scoping review was made using the Joanna Briggs Institute (JBI) methodology. CINALH, MEDLINE, SCOPUS e PUBMED were the databases used to search for the keywords informal caregivers, family caregiver, health literacy, empower, digital technology, and community. Inclusion criteria were made using the Population, Concept, and Context mnemonic and used as a record screening strategy. Paper relevance analysis was made by two independent reviewers, and the results were analysed according to their content.
Results: Nine studies were included, which verified that ICs used digital tools, such as computers and smartphones, with smartphones being the preferred tool. ICs use the Internet to access information, social and economic materials, home management tasks and communication with relatives, with their peers, healthcare professionals, and forums. Due to difficulties in leaving the house, forums are highly valued because this way ICs are still able to preserve human connections. There are factors that facilitate or complicate the use of digital tools by the ICs, and such information can be used to improve their user experience.
Conclusion: The use of digital technologies to convey clear, objective, reliable, and accessible information is a strategic action for promoting health literacy and for contemplating the variable care needs of ICs. By working with ICs in the development of new technologies, researchers are building a new tool that meets ICs’ needs.