bluuebunny/crossref_metadata_2025 huggingface dataset:
GPS, Accelerometer, and Smartphone Fused Smart Sensor for SHM on Real‐Scale Bridges
Authors: Guzman-Acevedo G. Michel , Vazquez-Becerra G. Esteban , Millan-Almaraz Jesus R. , Rodriguez-Lozoya Hector E. , Reyes-Salazar Alfredo , Gaxiola-Camacho J. Ramon , Martinez-Felix Carlos A.
Published: June 2019

During the last two decades, Global Positioning System (GPS) geodetic‐grade receivers and accelerometers have been implemented in Structural Health Monitoring (SHM). Most recently, the use of sensors integrated in smartphones has been evolving. Although some of their capabilities are validated for small and local structures, there is a gap in knowledge about the use of sensors embedded in smartphones and other electronic devices for SHM of complex structures as bridges. To contribute in this area, this paper demonstrates the application of GPS receivers, accelerometers, and smartphones, integrating a smart sensor for the SHM of bridges. In order to validate its capabilities, the alternative smart sensor is used to study a particular bridge with vibration problems. Semistatic and dynamic displacements are obtained by means of GPS measurements. Accelerations in three directions of the bridge are determined using the accelerometer and the smartphone. Based on the results of the alternative smart sensor, inappropriate structural behavior is detected in the vertical direction of the bridge. In addition, dynamic characteristics are extracted using the smart sensor applying the Fast Fourier Transformation (FFT) and periodogram to the structural responses. As a result, it is verified the applicability of the fused smart sensor for SHM on real‐scale bridges.
HepaticYAP1-TFE3Rearranged Epithelioid Hemangioendothelioma
Authors: Lotfalla Mira M. , Folpe Andrew L. , Fritchie Karen J. , Greipp Patricia T. , Galliano Gretchen G. , Halling Kevin C. , Mounajjed Taofic , Torres-Mora Jorge , Graham Rondell P.
Published: June 2019

Epithelioid hemangioendothelioma (EHE) is an uncommon low-grade malignant vascular tumor that may arise in soft tissue/bone or visceral sites such as the liver and lung. As this tumor exhibits epithelioid morphology, it frequently causes diagnostic confusion with other epithelioid vascular neoplasms as well as carcinoma. While 90% of classic EHE are driven by aWWTR1-CAMTA1fusion gene, a histologically distinctive subset of EHE has been recently shown to harbor a different fusion gene,YAP1-TFE3. This variant is likely underrecognized given its rarity and only recent description. Notably, EHE frequently involves the liver but only one case of hepaticYAP1-TFE3rearranged EHE has been reported to date. We present the second case ofYAP1-TFE3rearranged EHE affecting a 65-year-old woman and presenting as multiple liver masses, with characterization of the fusion gene at the transcriptomic and genomic levels. There are several educational points noted from this case.YAP1-TFE3rearranged EHE shows distinctly vasoformative foci, unlike classic EHE and mimicking angiosarcoma or epithelioid hemangioma. The tumors cells show a histiocytoid appearance with voluminous cytoplasm, similar to otherTFE3-rearranged tumors. Finally, in the liver, this tumor may in part mimic focal nodular hyperplasia of the liver which is an underrecognized diagnostic pitfall. This report highlights the key diagnostic and genetic features of this newly recognized variant of hepatic EHE to aid pathologists in appropriately classifying these tumors.
Numerical Computation of Brinkman Flow with Stable Mixed Element Method
Authors: Li Xindong , Xu Wenwen
Published: June 2019

Herein, we discuss a mixed finite element method applied to the Brinkman equation of fluid motion in porous medium, which covers a field of situation from the Darcy equation to the Stokes problem associated with various perturbation parameters. The finite element based on staggered meshes is shown to be stable and effective with each case as the corresponding error estimates for both velocity and pressure are established. Finally, we present numerical examples confirming the theoretical analysis and the stability of the finite spaces approximation.
Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells
Authors: Sun XiaoHu , Chang Xinzhong , Wang Yunhua , Xu Boyang , Cao Xuchen
Published: June 2019

Oroxylin A is a natural extract and has been reported to have a remarkable anticancer function. However, the mechanism of its anticancer activity remains not quite clear. In this study, we examined the inhibiting effects of Oroxylin A on breast cancer cell proliferation, migration, and epithelial-mesenchymal transition (EMT) and its possible molecular mechanism. The cytoactive and inflammatory factors were analyzed via Cell Counting Kit-8 assay and ELISA assay, respectively. Flow cytometry and western blotting were used to assess the cell proliferation. In addition, a wound healing assay and transwell assay were used to detect cell invasion and migration. qRT-PCR and western blot were employed to determine the effect of Oroxylin A on the EMT formation. Moreover, expression level of protein related to NF-κB signaling pathway was determined by western blot. The results revealed that Oroxylin A attenuated the cytoactivity of MDA-MB-231 cells in a dose- and a time-dependent manner. Moreover, cell proliferation, invasion, and migration of breast cancer cells were inhibited by Oroxylin A compared to the control. The mRNA and protein expression levels of E-cadherin were remarkably increased while N-cadherin and Vimentin remarkably decreased. Besides, Oroxylin A suppressed the expression of inflammatory factors and NF-κB activation. Furthermore, we also found that supplement of TNF-α reversed the effects of Oroxylin A on the cell proliferation, invasion, migration, and EMT in breast cancer cells. Taken together, our results suggested that Oroxylin A inhibited the cell proliferation, invasion, migration, and EMT through inactivating NF-κB signaling pathway in human breast cancer cells. These findings strongly suggest that Oroxylin A could be a therapeutic potential candidate for the treatment of breast cancer.
Asymptotic Analysis and Error Estimate for Rosenau‐Burgers Equation
Authors: Zhang Jun , Liu Zixin , Lin Fubiao , Jiao Jianjun
Published: June 2019

In this work, the asymptotic stability result for Rosenau‐Burgers equation is established, under appropriate assumptions on steady state eigenvalue problem and the forcing function. In addition, we propose and analyze a linearized numerical method for solving this nonlinear Rosenau‐Burgers equation. We prove that the numerical scheme is unconditionally stable, and the error estimate shows that the numerical method is in the order of , where Δt, N, and m are, respectively, step of time, polynomial degree, and regularity of u. Numerical examples are illustrated to verify the theoretical results.
ESTADO NOVO, AQRQUITETURA E “RENASCIMENTO NACIONAL”
Authors: Brites Joana Costa
Published: June 2019

Este artigo visa contextualizar e caracterizar a arquitetura do Estado Novo português no âmbito do seu propagandeado programa de “renascimento nacional”. Pese embora o tradicionalismo e conservadorismo do regime, procura-se demonstrar que a campanha de obras públicas constitui uma das suas vertentes de maior modernidade. Evidencia-se o caráter inclusivo da política cultural que o Estado Novo, à semelhança de outros fascismos, cultivou. Nesse sentido, analisa-se a relação entre arquitetos e Governo, o sistema de condicionamento artístico implementado, bem como a lógica de compromisso que a arquitetura do regime revela em torno da busca e da construção de um «moderno nacional».
LÓGICA CONVERSACIONAL, APRENDIZAGEM ARQUITETÔNICAS
Authors: Tapia mARTIN Carlos , Alves Manoel Rodrigues
Published: June 2019

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Editorial
Authors: Moreira Tomás Antonio , Trajano Filho Francisco Sales
Published: June 2019

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TRADICIÓN FUNCIONAL, RACIONALIDAD TÉCNICA Y VALOR ESTÉTICO - MOLIDOS Y SILOS CEREALEROS EN LA PAMPA HÚMEDA ARGENTINA
Authors: Collado Adriana
Published: June 2019

La metáfora de “granero del mundo” definió a Argentina durante un largoperíodo, dada su incorporación a la división internacional del trabajo comoproveedor de cereales, carnes y productos agroalimentarios. La metáfora sehacía presente en los artefactos necesarios para cumplir con ese rol, con locual la Pampa se convirtió en un itinerario de significación, marcado por elprogreso. Hoy el significado de esos artefactos se ha trastocado, trascendiendola valoración funcional o económica para convertirse en objetos estéticos. Esteartículo repasa esa significación en la obra de los artistas y arquitectos quejalonaron este proceso, buscando interpretar el carácter que ha adquirido lavaloración actual de estas formas.
Entrevista com Alberto Carneiro
Authors: Fernandes Francisco Barata , Medeiros Givaldo Luiz , Lancha Joubert Jose , Silva Maria Madalena Ferreira Pinto da , Castral Paulo Cesar , Vizioli Simone Helena Tanoue , Silva Vitor Manuel Oliveira da
Published: June 2019

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Entrevista com Joaquim Pinto Vieira
Authors: Fernandes Francisco Barata , Medeiros Givaldo Luiz , Lancha Joubert José , Silva Maria Madalena Ferreira Pinto da , Castral Paulo Cesar , Vizioli Simone Helena Tanoue , Silva Vitor Manuel Oliveira da
Published: June 2019

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O desenho como meio primevo de conhecimento
Authors: Lopes José Maria da Silva
Published: June 2019

O presente artigo discorre sobre algumas questões que se fizeram presentes no Colóquio Desenho + Projecto: Diálogo entre São Paulo e Porto e aborda o debate sobre os meios digitais e a prática do desenho. Apresenta o programa e a metodologia da Disciplina de Desenho ministrada na Faculdade de Arquitectura da Universidade do Porto, onde o desenho reforça a identidade do Curso, comparecendo como instrumento fundamental no processo projetivo.
Para aprender da pedra, frequentá-la
Authors: Lancha Joubert José
Published: June 2019

Uma obra de arte é depositária de um enorme número de desenhos; uns indispensáveis para a definição e realização de sua forma, outros secundários, mas não menos importantes, sempre permaneceram ao largo daqueles definitivos em estado de espera. Ao longo do tempo, esse numero de desenhos pode ir se acumulando, essa a sua grande riqueza. Como alternativa de aproximação à essa fortuna podemos então seguir o conselho de João Cabral de Melo Neto no poema ‘A Educação pela Pedra” e, para aprender do desenho, como da pedra, outra vez frequentá-lo.
Desenho e interdisciplinaridade: desenho em transversalidade
Authors: Hladkyi Daniela Zavisas
Published: June 2019

A cooperação estabelecida entre os cursos de arquitetura do IAU-USP (São Carlos-SP, Brasil) e da FAUP (Porto, Portugal) incentivou a pesquisa e a produção de trabalhos em vários níveis. No âmbito da pós-graduação desenvolvemos um estudo onde o confronto entre os procedimentos disciplinares das duas escolas foi objeto de investigação. Neste artigo buscamos analisar relações que partem das disciplinas de desenho nos dois cursos onde sempre se faz presente uma intenção de interação e proximidade com as atividades de projeto arquitetônico. Buscamos compreender como essas relações se dão do ponto de vista pedagógico nas esferas da interdisciplinaridade, multidisciplinaridade e transdisciplinaridade.
A new species of Nothochrysa from the latest Oligocene of France (Insecta: Neuroptera: Chrysopidae)

Authors: NGÔ-MULLER VALERIE , BLOT KILLYAN , NEL ANDRÉ
Published: June 2019

The green lacewings or Chrysopoidea are relatively rare in the fossil record, especially for the Cenozoic, while they seem to be rather diverse and frequent in the Mesozoic (Nel et al, 2005; Makarkin & Menon, 2005). The Chrysopidae seem to be better represented in the Eocene and the Miocene than in the Oligocene outcrops (e.g. Makarkin, 1991; Makarkin & Archibald, 2013). The Oligocene record for these insects is currently reduced to two species, both in the genus Nothochrysa McLachlan, 1868. Here we describe a new Oligocene green lacewing from the lacustrine Konservat-Lagerstätte of Aix-en-Provence.
First Dysmorphoptilidae from the Permian of China (Hemiptera: Cicadomorpha: Prosbolomorpha), with notes on the fossil record of the family

Authors: SZWEDO JACEK , HUANG DIYING
Published: June 2019

The first representative of Dysmorphoptilidae from the Middle Permian of China is described. Linglunxiellus chaohuensis gen. and sp. nov. is placed together with Permocixiella venosa Becker-Migdisova, 1961 from Kuznetsk Basin in the newly established subfamily Permocixiellinae subfam. nov., Eoscarterellinae stat. nov. is proposed as separate subfamily within Dysmorphoptilidae. The classification and fossil record of Dysmorphoptilidae is reviewed, and an annotated catalogue of included taxa in Dysmorphotiloidea is presented.
A new dustywing (Neuroptera: Coniopterygidae) from the Early Cretaceous amber of Spain

Authors: PÉREZ-DE LA FUENTE RICARDO , DELCLÒS XAVIER , ENGEL MICHAEL S. , PEÑALVER ENRIQUE
Published: June 2019

A new Cretaceous dustywing, Soplaoconis ortegablancoi gen. et sp. nov. (Neuroptera: Coniopterygidae), is described from four specimens preserved in Early Cretaceous (Albian, ~105Ma) El Soplao amber (Cantabria, northern Spain). Two additional specimens are assigned to this new taxon. A crossvenational abnormality on an area of diagnostic significance from one of the holotype’s forewings provides a reminder of the importance of not ruling out character plasticity or teratoses when evaluating palaeodiversity. A comment on the possible palaeoecological significance of the co-occurrence as syninclusions of plant trichomes with the holotype of S. ortegablancoi and seven of the eleven described Burmese amber dustywing species is provided.
Santonian cockroaches from Yantardakh amber (Russia: Taimyr) differ in dominance

Authors: VRŠANSKÝ PETER
Published: June 2019

Cretaceous amber cockroaches are known only from Lebanon, Myanmar and France. An assemblage of 14 dictyopterans (2 unidentified) from Santonian amber of Yantardakh, Taimyr, Russia is reported here, comprising only 0.3 % of ˃5,000 collected insects. Small pieces (0.03–0.30 g) contain six immature individuals of Liberiblattinidae, one predatory Ocelloblattula or its close relative, one Perlucipecta immature (Mesoblattinidae), one represents typical Blattulidae and Chaeteessites minutissimus along with two primitive true mantodeans. The assemblage lacks any modern taxon, common in other Upper Cretaceous sedimentary rocks and ambers, while diverse parasitic Evaniidae indirectly confirms the presence of them. A biome with a diversity of otherwise rare Liberiblattinidae (emended diagnosis revealed herein) with high evolutionary potential expressed in giving rise to numerous other families was thus present. Differences observed were probably caused by another source tree as evidenced by the different chemistry of Taimyr amber compared to other ambers.
First fossil record of the genus Reissa Evenhuis & Báez (Diptera: Mythicomyiidae: Mythicomyiinae) from the Eocene Green River Formation of North America, and discussion of biogeographical implications

Authors: EVENHUIS NEAL L.
Published: June 2019

The genus Reissa Evenhuis & Báez in Greathead & Evenhuis (2001) was originally described based on a short series of extant specimens from the island of Tenerife in the Canary Islands. No further species of the genus have been discovered since. A related fossil genus (Riga Evenhuis) was described from Eocene Rovno amber (Evenhuis, 2013) and has some characters in common with the fossil specimen but differs in thoracic and antennal features. The new species described and illustrated here is represented by a single compression fossil of the new species Reissa kohlsi sp. nov. from the Parachute Creek member of the Green River Formation of Wyoming/Utah/Colorado, USA, the site of which dates from 51.2–48.7 my (Smith et al., 2008). It marks the first fossil record of the genus and its first record from the New World, and the first fossil record of the family Mythicomyiidae from North America. The family was previously known in the New World fossil record from the Miocene Dominican amber (cf. Evenhuis, 2013), including two representatives from the Mythicomyiinae (Mythicomyia dominicana Evenhuis, 2002 and Pieza dominicana Evenhuis, 2002).
First Mycetobiinae of the lowermost Eocene Oise amber (France) (Diptera: Anisopodidae)

Authors: CAMIER MARIE , NEL ANDRÉ
Published: June 2019

The Anisopodidae Knab, 1912 is an ancient family of Diptera, with several extant genera well represented in the Paleogene. It is especially the case for the genus Mycetobia Meigen, 1818, known by several Baltic amber species (Wojton et al., 2019a, b). On the contrary, the extant paleotropical genus Mesochria Enderlein, 1910 is currently known by two fossil species from the Eocene Chinese amber and the Miocene Dominican amber (Grimaldi, 1991; Szadziewski et al., 2016). Here we report the first European species of Mesochria, from the lowermost amber of Oise (France), greatly extending the past distribution of this genus.
Improved Multifractal Fusion Method to Blend SMOS Sea Surface Salinity Based on Semiparametric Weight Function
Authors: Yan Hengqian , Zhang Ren , Wang Gongjie , Wang Huizan , Chen Jian , Bao Senliang
Published: June 2019

The multifractal fusion method has proved to be an effective algorithm to mitigate the noise of the sea surface salinity (SSS) of Soil Moisture Ocean Salinity (SMOS) mission. However, the traditional nonparametric weight function used in this method is unable to fully capture the dynamic evolution of the oceanic environment. Considering the multiscale, nonuniform, anisotropic, and flow-dependent nature of the ocean, a prototype with the so-called flexible circle (FLC) weight function or flexible ellipse (FLE) weight function with a set of predefined parameters is proposed in this paper. The improved weight functions could draw dynamic information from the sea surface temperature, Rossby radius of deformation, and surface geostrophic flow to improve the quality of the remotely sensed SSS. The validation against the in situ data indicates that the improved weight functions perform better than the traditional one with a reduced root-mean-square (RMS) and standard deviation (STD) of the differences with respect to EN 4.2.0 profiles (from 0.50 and 0.46 to 0.42 and 0.38 for FLC and 0.39 and 0.36 for FLE in the global ocean). In particular, the FLE scheme could highlight the variation of the strong currents without affecting the computational efficiency. Furthermore, this paper discusses the influences of the error distribution on the fusion results and underlines the importance of error-based adaptions for further improvements.
A finite-time sliding mode control for hypersonic vehicle
Authors: Ma Qingwen , Guo Jianguo , Zhou Jun
Published: June 2019

In this paper, a finite-time control strategy based on back-stepping method combining with a terminal sliding mode control (TSMC) and a nonlinear disturbance observer (NDO) is proposed for the longitudinal dynamic model of hypersonic vehicle (HV). Firstly, the model of HV is transformed into two strict feedback subsystem: the mismatched subsystem of altitude and the matched subsystem of velocity. Then, the TSMC and back-stepping method is incorporated to cope with the unmatched issue in the HV altitude subsystem. In addition, a NDO based on a finite-time-convergent differentiator (FD) is proposed to estimate the lumped disturbances. The finite-time stability condition of the system is established via the Lyapunov theory. Finally, the robustness and effectiveness of the method are verified by simulations.
Parental strategies used in communication with their deaf infants
Authors: Beatrijs Wille , Kristiane Van Lierde , Mieke Van Herreweghe
Published: June 2019

One way of increasing caregivers’ language accessibility when interacting with a deaf child is through visual communication strategies. By using both a longitudinal and cross-sectional approach, this study will reveal which strategies deaf and hearing parents prefer and implement in their daily communication with their deaf children. First, the interactions of one deaf and two hearing mothers with their deaf children were recorded over the course of 18 months starting when their children were 6 months of age. Second, interactions of 5 mothers and 5 fathers (i.e. each two deaf and three hearing) with their deaf children (24 months old) were analysed for implicit and explicit strategy-use. It indicated gender related differences and confirmed caregivers’ tendencies to rely on strategies closely related to the modality of their mother tongue. Finally, deaf parents outperformed the hearing parents in the duration of successful interaction moments with their deaf children.
Comparison of VOTs in Mandarin–English bilingual children and corresponding monolingual children and adults
Authors: Yang Jing
Published: June 2019

Word-initial stops in Mandarin and English show a distinctive phonological categorization but a similar phonetic realization along the VOT (Voice Onset Time) continuum. Previous research reported that native Mandarin adults produce measurably longer long-lag VOTs than native English adults. The present study examined whether and how the difference between Mandarin and English VOTs is manifested in monolingual children and Mandarin–English bilingual children. The participants included 15 five- to six-year-old sequential bilingual children, 24 corresponding monolingual children (15 Mandarin, 9 English), and 22 monolingual adults (12 Mandarin, 10 English). The bilingual children were divided into two groups (Bi-low and Bi-high) based on the amount of experience in English. Each participant was recorded producing 18 Mandarin words and/or 18 English words containing six stops in each language. The VOT values were measured from the beginning of stop burst to the onset of the voicing. The results showed that the language difference in VOT in the monolingual children was manifested in a pattern similar to the monolingual adults. However, Mandarin and English VOTs showed less separable distributions in the two groups of bilingual children. Further analysis suggested that both groups of bilingual children tended to separate Mandarin and English short-lag VOTs but only the Bi-low children showed different long-lag VOTs between the two languages. These results suggested that due to the bilingual effects and L1–L2 (first language – second language) interactions, even though the bilingual children tried to separate the two VOT systems, they implemented the separation in a different manner than the monolingual speakers.
Assessing the Economic Value of Pharmacy Resident Participation in an Investigational Drug Service
Authors: Brown Jamie N. , Gordon Sara E. , Tillman Frank , Jacob Sherin , Britnell Sara R.
Published: June 2019

Purpose:

Completion of postgraduate residency training gives pharmacists an opportunity to gain advanced practice experience, yet the availability of these positions is often limited. Through participation in an investigational drug service (IDS), residency programs may be able to expand learning experiences while demonstrating a financial benefit to the institution. The purpose of this assessment is to examine the economic value generated by pharmacy resident involvement within an IDS.

Methods:

This was a single-center retrospective record review. All resident dispensations within the IDS from January 1, 2016, to December 31, 2017, were evaluated for cost avoidance, revenue, and waived revenue. Cost avoidance was defined as the cost of medications the institution would have incurred had the sponsor not provided therapies free of charge. Medical center contract acquisition costs were used to determine cost avoidance. Total economic value accounted for the personnel costs of resident dispensations. Descriptive statistics were utilized for all assessments.

Results:

A total of 444 resident dispensations occurred during the study period on 15 IDS protocols. The total cost avoidance for resident dispensations was US$144 898. Total revenue for these dispensations was US$1424, and waived revenue fees totaled US$17 625. After accounting for the personnel cost of dispensations by the residents, the total economic value of resident participation in the IDS was US$159 150.

Conclusion:

Resident participation in the IDS contributed economic value to the institution. The IDS provides a unique learning experience for the pharmacy residents, cost savings for the institution, and supports the advancement of patient care.
Particle image velocimetry experiment of the inlet flow field in a mixed-flow pump during the startup period
Authors: Li Wei , Ji Leilei , Shi Weidong , Li Enda , Ma Lingling , Yang Zhengyu
Published: June 2019

The transient characteristics of the inlet flow field of mixed-flow pump during start-up process are hard to be measured experimentally. The elbow structure with viewport is designed before the mixed-flow pump for capturing the transient inlet flow fields of the mixed-flow pump. Meanwhile, the synchronous data acceptance system is also designed to collect the data from different sensors synchronously. Besides, uncertainty analysis is carried out after the experiment to ensure the accuracy and reliability of this test system. The transient external characteristics are obtained and the velocity distribution of a mixed-flow pump during the startup period is measured using particle image velocimetry technique. The results show that the overall uncertainty for the external characteristics was 0.2345%, which indicates the high accuracy of this test bench for capturing the transient flow condition in the mixed-flow pump during the startup period. At the beginning of the start-up process, the head of the mixed-flow pump increases and reaches the maximum once the rotation speed meets the maximum value and an instantaneous impulsive head appears at the end of the accelerating process. However, with the increase of the rotating speed, wall boundary layer gradually develops from laminar to turbulent flow, and the flow moves continuously from the hub center to the inlet. At the end stage of the accelerating process, more intensive entrainment effect of the impeller is found. When the rotation speed is steady, the influence of the elbow on the internal flow fields gradually decreases, compared with the startup process. The results can serve as a fundamental reference for the investigation of transient flow characteristics of the mixed-flow pump during the startup period.
Stated Preferences for Firm’s Characteristics and Asset Allocation Decisions
Authors: Khan Mohammad Tariqul Islam , Tan Siow-Hooi
Published: June 2019

The present article investigates the relationship between stated preferences for firm’s characteristics and asset allocation decisions. Data from the survey of retail investors in Malaysia are used for estimations by employing binary logit and ordered logistic models. The analyses show that preferences for a firm’s value characteristics, quality of management and product characteristics, risky characteristics, liquidity and trading volume characteristics affect holding of a particular financial asset, number of asset holding, quite diversified portfolio holding and hypothetical asset allocation. However, a firm’s characteristics have no influence on fully diversified portfolio. In Malaysia, the regulators may consider the investor’s preferences for specific firm’s characteristics in designing policies to reduce the apparent structural imbalance in the capital market.
Responding to Intimate Partner Violence: Urban Women’s Decisions About Getting Personal Protection Orders When Other Resources are Scarce
Authors: Weisz Arlene N. , Schell Maria
Published: June 2019

Intimate partner violence continues to be a widespread and serious problem. African American women experience a high lifetime prevalence of physical intimate partner violence, but resources for them are often scarce. This mixed-methods analysis of telephone survey responses found that women who were African American, had less education, and were dissatisfied with criminal justice responses to an abusive incident were less likely to seek personal protection orders (PPOs). The qualitative analysis showed that many women did not seek POs because their assessment of their partners indicated it was not needed or increased risk. Practical obstacles in obtaining orders were noteworthy.
Study of the bond behaviour between basalt fibre-reinforced polymer bar/sheet and bamboo engineering materials
Authors: Lv Qingfang , Ding Yi , Liu Ye
Published: June 2019

To improve practical application of modern bamboo structures, strengthening the bamboo engineering material is necessary to overcome insufficient stiffness. As an essential step in developing fibre-reinforced polymer–bamboo engineering material composite structures aimed at increasing the structural stiffness, the bonding behaviour at the interface of the fibre-reinforced polymer and bamboo engineering materials should be investigated in detail because currently there is a lack of research. In this article, bonding behaviour is studied between basalt fibre-reinforced polymer bar and bamboo engineering material including laminated and reconstituted bamboo and between basalt fibre-reinforced polymer sheets and laminated bamboo. Failure patterns are categorized, and the load–slip curves are discussed. Based on the failure pattern and strain variation, recommended bond lengths were proposed for the basalt fibre-reinforced polymer bar–bamboo engineering material and basalt fibre-reinforced polymer sheet–laminated bamboo composite specimens, respectively. In addition, a simplified three-phase bond–slip model was proposed for the basalt fibre-reinforced polymer bar–bamboo engineering material composite specimen.
The Dentate Gyrus and Temporal Lobe Epilepsy: An “Exciting” Era
Authors: Scharfman Helen E.
Published: June 2019

This review describes developments in epilepsy research during the last 3 to 4 decades that focused on the dentate gyrus (DG) and its role in temporal lobe epilepsy (TLE). The emphasis is on basic research in laboratory animals and is chronological, starting with hypotheses that attracted a lot of attention in the 1980s. Then experiments are described that addressed the questions, as well as new methods that often made the experiments possible. In addition, where new questions arose and the implications for clinical epilepsy are discussed.
Understanding adverse drug-related emergency department visits: development of a conceptual model through a systematic review
Authors: Jatau Abubakar Ibrahim , Shitu Zayyanu , Khalid Garba Mohammed , Yunusa Ismaeel , Awaisu Ahmed
Published: June 2019

Background:

The burden of adverse drug event (ADE)-related emergency department (ED) visits is increasing despite several preventive measures. The objective of this paper was to develop and validate a conceptual model for a better understanding of ADE-related ED visits and to guide the design and implementation of effective interventions.

Methods:

The development of the model involved a systematic review of the literature using PubMed and Embase databases. Studies reporting the risk factors associated with ADE-related ED visits were included. The methodological qualities of the included studies were assessed using the Mixed Methods Appraisal Tool (MMAT). The model was mapped and validated using face and content validity by an expert panel. Deficiencies and targeted interventions were identified, and steps for the design and implementation were recommended.

Results:

The literature search generated 1361 articles, of which 38 were included in the review; 41 risk factors associated with ADE-related ED visits were identified. All factors were mapped, and the model was validated through face and content validity. The model consisted of six concepts related to sociodemographic factors, clinical factors, ADE-related to ED visits, ADE while in the ED, outcomes, and consequences. Interventions could be targeted at the factors identified in each concept to prevent ADE-related ED burden.

Conclusion:

A conceptual model to guide the successful design and implementation of strategies to prevent ADE-related ED visits and the occurrence of ADE at ED was developed. Clinicians should take these factors into consideration to prevent untoward events, especially when treating high-risk patients.
The long-term effect of an exercise and diet intervention in asthma patients: a 1-year follow-up on a randomised controlled trial
Authors: Bentzon Adrian Koch , Loehde Linda Wolfgang , Backer Vibeke , Toennesen Louise
Published: June 2019

Background

In the EFFORT (Effects of Exercise and Diet in Nonobese Asthma Patients – A Randomized Controlled Trial) study, maximum exercise capacity (V′O2max) increased significantly within a 2-month high-intensity spinning period. Furthermore, the study concluded that only the combined exercise and diet intervention improved asthma control, significantly. This study examined whether original improvements inV′O2maxand asthma control were present 1 year after intervention completion.

Method

In the original trial, 149 patients were randomised into four study groups. Participants were assessed with an incremental cycle ergometer test and the Asthma Control Questionnaire (ACQ). Of the 149 patients, 66 accepted the follow-up invitation. Participants were distributed in their original groups: exercise group (n=18), diet group (n=117), combined diet and exercise group (n=115) and the control group (n=110). Patients were assessed with original procedures. Though, upon measuringV′O2max, the original four study groups were merged into one spinning group (n=127) and one nonspinning group (n=133).

Results

Comparing the spinning and nonspinning group, there was no significant between-group difference inV′O2max, at 1-year follow-up (p=0.3). In addition, there was no significant between-group difference in ACQ score (p=0.6). Hence, in the combined group, the initial improvement in the ACQ score had regressed to pre-intervention values within 1 year from study completion.

Conclusion

There were no measurable long-lasting effects onV′O2max1 year after the intervention was completed. Furthermore, there was no long-lasting effect of the combined intervention on asthma control.
A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program
Authors: Srinivasan Shylaja , Jablonski Kathleen A , Knowler William C , Dagogo-Jack Samuel , E. Kahn Steven , Boyko Edward J , Bray George A , Horton Edward S , Hivert Marie-France , Goldberg Ronald , Chen Ling , Mercader Josep , Harden Maegan , Florez Jose C ,   Diabetes Prevention Program Research Group
Published: June 2019

Context

There is substantial heterogeneity in insulin sensitivity, and genetics may suggest possible mechanisms by which common variants influence this trait.

Objectives

We aimed to evaluate an 11-variant polygenic lipodystrophy genetic risk score (GRS) for association with anthropometric, glycemic and metabolic traits in the Diabetes Prevention Program (DPP). In secondary analyses, we tested the association of the GRS with cardiovascular risk factors in the DPP.

Design

In 2713 DPP participants, we evaluated a validated GRS of 11 common variants associated with fasting insulin-based measures of insulin sensitivity discovered through genome-wide association studies that cluster with a metabolic profile of lipodystrophy, conferring high metabolic risk despite low body mass index (BMI).

Results

At baseline, a higher polygenic lipodystrophy GRS was associated with lower weight, BMI, and waist circumference measurements, but with worse insulin sensitivity index (ISI) values. Despite starting at a lower weight and BMI, a higher GRS was associated with less weight and BMI reduction at one year and less improvement in ISI after adjusting for baseline values but was not associated with diabetes incidence. A higher GRS was also associated with more atherogenic low-density lipoprotein peak-particle-density at baseline but was not associated with coronary artery calcium scores in the Diabetes Prevention Program Outcomes Study.

Conclusions

In the DPP, a higher polygenic lipodystrophy GRS for insulin resistance with lower BMI was associated with diminished improvement in insulin sensitivity and potential higher cardiovascular disease risk. This GRS helps characterize insulin resistance in a cohort of individuals at high risk for diabetes, independent of adiposity.
Transplanting gravid lizards to high elevation alters maternal and embryonic oxygen physiology, but not reproductive success or hatchling phenotype
Authors: Kouyoumdjian Laura , Gangloff Eric J. , Souchet Jérémie , Cordero Gerardo A. , Dupoué Andréaz , Aubret Fabien
Published: June 2019

Increased global temperatures have opened previously inhospitable habitats, such as at higher elevations. However, the reduction of oxygen partial pressure with increase in elevation represents an important physiological constraint that may limit colonization of such habitats, even if the thermal niche is appropriate. To test the mechanisms underlying the response to ecologically-relevant levels of hypoxia, we performed a translocation experiment with the common wall lizard (Podarcis muralis), a widespread European lizard amenable to establishing populations outside its natural range. We investigated the impacts of hypoxia on the oxygen physiology and reproductive output of gravid common wall lizards and the subsequent development and morphology of their offspring. Lowland females transplanted to high elevations increased their haematocrit and haemoglobin concentration within days and maintained routine metabolism compared to lizards kept at native elevations. However, transplanted lizards suffered from increased reactive oxygen metabolite production near the oviposition date, suggesting a cost of reproduction at high elevation. Transplanted females and females native to different elevations did not differ in reproductive output (clutch size, egg mass, relative clutch mass, or embryonic stage at oviposition) or in post-oviposition body condition. Developing embryos reduced heart rates and prolonged incubation times at high elevations within the native range and at extreme high elevations beyond the current range, but this reduced oxygen availability did not affect metabolic rate, hatching success, or hatchling size. These results suggest that this opportunistic colonizer is capable of successfully responding to novel environmental constraints in these important life-history stages.
ХАРАКТЕРИСТИКА ПАРАМЕТРОВ ВЕГЕТАТИВНОЙ РЕГУЛЯЦИИ У ДЕТЕЙ С НАРУШЕНИЕМ ИНТЕЛЛЕКТУАЛЬНОГО РАЗВИТИЯ
Authors: Ovcharenko Elizaveta Sergeevna , Fefelova Vera Vladimirovna , Kasparov Edward Villiamovich , Smirnova Olga Valentinovna
Published: June 2019

Нами были обследованы 100 детей 7–11 лет, из них 18 детей имели диагноз умственная отсталость и воспитывались в специализированном детском доме. Контрольную группу составили 82 школьника той же возрастной группы. Функциональное состояние вегетативной нервной системы оценивалось методом кардиоинтервалографии, с последующим расчетом производных индексов. В ходе исследования было зафиксировано значительное усиление активности парасимпатического звена ВНС на фоне снижения активности симпатической регуляции у детей-сирот с умственной отсталостью, что может свидетельствовать о нарушении механизмов вегетативной регуляции в этой группе детей. Выявленные отклонения могут быть связаны с влиянием разносторонней депривации, свойственной всем воспитанникам интернатных учреждений.
ОСОБЕННОСТИ ПРО- И АНТИОКСИДАНТНОЙ СИСТЕМ ЭРИТРОЦИТОВ БОЛЬНЫХ КОЛОРЕКТАЛЬНЫМ РАКОМ
Authors: Perepechay Yaroslava Igorevna , Smirnova Olga Valentinovna , Titova Nadezhda Mitrofanovna , Glazkova Margarita Olegovna , Borisova Violetta ValeriSiberian Federal Universityevna , Kurchenko Andrei Evgenievich , Timofeeva Anna Andreevna , Mishina Viktoria Alexandrovna , Efimova Oksana Andreevna
Published: June 2019

В данной работе изучаются прооксидантные и антиоксидантные процессы в эритроцитах больных колоректальным раком. О работе АОС судили по содержанию восстановленного глутатиона, активности супероксиддисмутазы, каталазы, глутатионпероксидазы и глутатион-S-трансферазы. Состояние прооксидантной системы оценивали по уровню диеновых конъюгатов и малонового диальдегида. У больных колоректальным раком показано снижение активности антиоксидантных ферментов и интенсификация перикисного окисления липидов.
ОЦЕНКА ПРОЛИФЕРАТИВНО-АПОПТОТИЧЕСКОГО СТАТУСА ЭПИТЕЛИОЦИТОВ СЛИЗИСТОЙ ОБОЛОЧКИ ЖЕЛУДКА У ПАЦИЕНТОВ С АТРОФИЧЕСКИМ ГАСТРИТОМ
Authors: Peretyat’ko Olga Viktorovna , Tsukanov Vladislav Vladimirovich , Pulikov Anatoliy Stepanovich
Published: June 2019

Изучение показателей клеточного обновления эпителиоцитов слизистой оболочки желудка при атрофическом гастрите может оптимизировать диагностические и терапевтические подходы, учитывая, что данная форма гастрита является предраковым заболеванием. Методом иммуногистохимии были определены маркеры пролиферации и апоптоза Ki-67, PCNA, p53 и bcl-2 в гастробиоптатах больных в возрасте 45–60 лет неатрофическим и атрофическим гастритом. В результате исследования был определен пролиферативно-апоптотический статус эпителиоцитов слизистой оболочки желудка, который позволяет сделать вывод о снижении репаративных процессов.
ХАРАКТЕРИСТИКА КОНСТИТУЦИИ И ТИПА ТЕМПЕРАМЕНТА У ЛИЦ ЮНОШЕСКОГО ВОЗРАСТА В ЗАВИСИМОСТИ ОТ ПОЛА И КЛИМАТА
Authors: Avabde Diana Salimovna , Piskareva S. A. , Gvardeeva Sabrina Gamalevna , Ageeva Elizaveta Sergeevna
Published: June 2019

В статье представлены данные физического развития студентов в зависимости от их конституционального типа, темперамента, пола и климатической зоны проживания. Показано, что наиболее значимыми различиями по частоте встречаемости в обследованных когортах обладают конституциональные типы и типы темперамента, которые различались у студентов, проживающих в зоне умеренного, субэкваториального и субтропического климата.
КЛАСТЕРНЫЙ АНАЛИЗ РЕГОНОВ РОССИИ ПО ПОКАЗАТЕЛЯМ ЗАБОЛЕВАЕМОСТИ НЕКОТОРЫМИ СОЦИАЛЬНО-ЗНАЧИМЫМИ ЗАБОЛЕВАНИЯМИ
Authors: Braur Elsa Vladimirovna , Kurbanismailov Renat Badrudinovich , Narkevich Artem Nikolaevich
Published: June 2019

В статье представлены результаты кластерного анализа регионов Российской Федерации по заболеваемости социально-значимыми заболеваниями. Установлено, что Красноярский край входит в неблагоприятный кластер. Чтобы перейти в благополучный кластер, региону необходимо в качестве одного из приоритетов системы здравоохранения рассмотрение вопроса о снижении заболеваемости по всем анализируемым социально-значимым заболеваниям.
ХЕМИЛЮМИНЕСЦЕНТНАЯ АКТИВНОСТЬ НЕЙТРОФИЛОВ У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА С РАЗНОЙ ЧУВСТВИТЕЛЬНОСТЬЮ К АЦЕТИЛСАЛИЦИЛОВОЙ КИСЛОТЕ
Authors: Vselov Andrey Evgenievich
Published: June 2019

С целью изучения особенностей хемилюминесцентной активности нейтрофилов у чувствительных и резистентных к ацетилсалициловой кислоте (АСК) больных ишемической болезнью сердца (ИБС) обследовано 53 пациента с ИБС. Больные разделены на группы чувствительных и резистентных к АСК. Состояние респираторного взрыва в нейтрофилах оценивали с помощью хемилюминесцентного метода. Установлено, что у больных ИБС наблюдается замедленная скорость развития респираторного взрыва в нейтрофилах. У резистентных к АСК больных обнаружено снижение индекса активации.
ИСПОЛЬЗОВАНИЕ ДНК, ВЫДЕЛЕННОЙ ИЗ ОБРАЗЦОВ КОСТНОГО МОЗГА В ПАРАФИНОВЫХ БЛОКАХ ОТ ПАЦИЕНТОВ С ХМН, ДЛЯ АНАЛИЗА СОМАТИЧЕСКИХ МУТАЦИЙ
Authors: Kurochkin Dmitry Vladimirovich , Karnyushka Anastasia Aleksandrovna , Petrichenko Tatyana Yuryevna , Subbotina Tatiana Nikolaevna , Garkusha Tatyana Andreevna , Khazieva Anna Sergeevna , Khorzhevsky Vladimir Alekseevich
Published: June 2019

Хронические миелопролиферативные неоплазмы (ХМН) – клональные заболевания, характеризующиеся нарушением пролиферации миелоидной линии клеток в костном мозге. Для подтверждения диагноза и определения фенотипической формы, ВОЗ рекомендуется проведение молекулярно-генетических исследований. Предполагается, что исследование ДНК, выделенной из костного мозга в парафиновых блоках от тринегативных пациентов с ХМН, позволит выявить соматические мутации (в генах JAK2, CALR, MPL), ассоциированные с ХМН. В данной работе показано, что ДНК из костного мозга в парафиновых блоках от пациентов с ХМН пригодна для генетических исследований.
Genome Wide Association Study of an Association between Gene Polymorphisms and the Increased Frequency of Cytogenetic Abnormalities in the Persons Exposed to Long-Term Irradiation
Authors: Халюзова М. , Khalyuzova M. , Цыганов М. , Tsyganov M. , Исубакова Д. , Isubakova D. , Брониковская Е. , Bronikovskaya E. , Усова Т. , Usova T. , Литвяков Н. , Litviakov N. , Карпов А. , Karpov A. , Тахауова Л. , Takhauova L. , Тахауов Р. , Takhauova T.
Published: June 2019

Purpose: To conduct genome wide association study of the association of 750,000 SNPs and an increased frequency of different types of chromosomal aberrations, induced by chronic irradiation in the dose range of 100–300 mSv.

Material and methods: The study was conducted among Siberian Group of Chemical Enterprises healthy employees (n = 37) exposed to professional external γ-radiation in a dose range of 100–300 mSv. The de novo induced CNVs were previously detected in these persons. Mean dose – 188.8 ± 8.3 mSv, median – 185 mSv, interquartile range – 147.8–218.7 mSv, min – 103.4 mSv, max – 295.8 mSv. Genotyping of DNA samples from 37 employees was carried out by microarray CytoScan™ HD Array (Affymetrix, USA), containing 750,000 SNP-markers of 36,000 genes. The standard cytogenetic analysis was performed in the entire examined group.

Results: We analyzed the association of these SNPs with the frequencies of aberrant cells and following chromosomal aberrations: single chromatid fragments, chromatid exchanges, paired fragments, dicentrics, rings, and translocations. We have found that 8 SNPs (rs10779468, rs158735, rs158710, rs158712, rs11131536, rs528170, rs9533572, rs10512439) are associated with the frequency of aberrant cells.

Conclusion: We have discovered polymorphic variants that are associated with an increased frequency of aberrant cells in workers of Siberian Group of Chemical Enterprises exposed to irradiation at a dose of 100–300 mSv. This polymorphic variants can be considered as potential markers of individual radiosensitivity. To confirm identified associations, further validation studies on an extended sample of people exposed to radiation are needed.
Leakage Radiometric Control of Chemical Drugs with Regional Perfusion of Surgical Isolated Limbs
Authors: Наркевич Б. , Narkevich B. , Ширяев С. , Shiryaev S. , Лагутина И. , Lagutina I. , Буйденок Ю. , Buydenok Yu. , Харатишвили Т. , Kharatishvili T. , Петроченко Н. , Petrochenko N.
Published: June 2019

Purpose: Modernization and evaluation of the clinical effectiveness of the technology of continuous radiometric monitoring carried out during high-dose chemotherapy of a surgically isolated limb with tumor foci.

Material and methods: A modernized radiometric control technology for regional limb perfusion is proposed. It is based on in vivo labeling of erythrocytes with 99mTc eluate followed by continuous monitoring of the activity of labeled erythrocytes as a simulator of a chemotherapy drug over the heart region. Its distinctive features are intravenous injection of a pyrfotech slice after giving inhalation anesthesia to ensure a sufficient level of red blood cell chelation, as well as using 99mTc activity less than its minimum significant level, which allows working with an open source of ionizing radiation without violating the requirements of radiation safety regulations.

Results: The developed technology was successfully used with 106 regional perfusion of the upper and lower extremities in patients with melanoma or sarcoma of soft tissues. In 4 cases, according to the results of radiometric control, the intervention of the surgical team was required to reduce the chemical preparation leakage that was occurring.

Conclusion: The technology upgraded by us is characterized by ease of implementation, the ability to take timely measures to prevent or reduce the leakage of a chemotherapy drug from an isolated limb according to the results of continuous in vivo radiometric monitoring of 99mTc-labeled red blood cells over the heart, as well as low radiation load on the patient and staff.