bluuebunny/crossref_metadata_2025 huggingface dataset:
Peritonitis asociada a diálisis en pacientes con diálisis peritoneal automatizada vs. diálisis peritoneal continua ambulatoria.
Authors: Domínguez Fierro Eduardo , Pasten López Estrella Elizabeth , Mejía Miranda Néstor
Published: June 2024

Introduction: The number of people requiring dialysis in Mexico increases between 6% and 12% annually. Peritoneal dialysis (PD)- related peritonitis is the leading cause of a permanent transition to hemodialysis. Its appearance is associated with prolonged hospitalization, increased morbidity and mortality, higher costs, and increased long-term sequelae of the peritoneal membrane. The study aimed to describe the epidemiology of patients with dialysis-associated peritonitis treated in the emergency department at a referral hospital in Mexico, comparing treatment modalities.
Methods: The present observational, analytical, retrospective study was conducted from March 2021 to February 2022 at the General Hospital of Zone and Family Medicine 1 of Pachuca-Hidalgo. The variables were demographic, clinical, and laboratory. Descriptive statistics, proportions, and confidence intervals for a proportion are used. An analysis is presented comparing the two PD modalities.
Results: 142 confirmed cases are compared to the target statistical population of 1147 patients, with an infection rate of 12.3% (95% CI 10.4%-14.2%). In APD, they were 56/642 (0.0872 cases/patient/year), and in CAPD, they were 86/505 (0.170 c/p/a) P<0.0001. The most frequent etiology was E.coli (36.28%).
Conclusion: Los pacientes en programas de diálisis peritoneal automatizada tuevieron una menor prevalencia de peritonitis comparada con el grupo de diálisis peritoneal continua ambulatoria.
Síndrome de Sagliker: una nueva entidad, un problema antiguo.
Authors: Ortiz Vilorio Annel , Jiménez Guzmán Dominga , Trinidad Ramos Pedro
Published: June 2024

Introduction: Sagliker syndrome, described by Dr. Yahya Sagliker in 2004, constitutes the most advanced state of secondary hyperparathyroidism in chronic kidney disease. Deforming and disabling clinical syndrome that reduces the quality of life and adds psychological disorders to the patient with chronic kidney disease. This study aims to report on a series of eight cases in Mexico and warn about the correct management and follow-up of secondary hyperparathyroidism.
Cases: 8 cases are presented with ages between 17 and 35 years, serum parathyroid hormone levels between 1583 and 4715 pg/ml, and alkaline phosphatase levels between 146 and 2065 IU/L. All cases with brown tumors in the maxilla and mandible characteristic of Sagliker syndrome.
Evolution: All patients were ingesting calcium and vitamin D analogs at diagnosis or in the last three months.
Conclusion: Sagliker syndrome is the most severe and chronic complication of secondary hyperparathyroidism and chronic kidney disease. The significant bone involvement of this syndrome generates a disabling facial and prolonged bone deformity that impacts morbidity, mortality, and mental health. Concomitant with bone alterations, vascular and cardiac calcifications add a crucial cardiovascular risk, so any surgery constitutes a high risk.
Fallo renal agudo y sepsis en el paciente oncológico.
Authors: Quinchuela Hidalgo Jorge
Published: June 2024

Introduction: The precise incidence of acute kidney injury (AKI) in the population oncology remains unknown; however, the impact is strong on morbidity and mortality and in hospitalization costs. Sepsis and hypoperfusion are very common etiologies of AKI in cancer patients converge on pre-renal and intrinsic causes.
Objective of the review: The review aims to describe the main aspects of pathophysiological and establish diagnostic and treatment criteria in patients with Acute kidney injury and sepsis in cancer patients.
Essential points of the review: A significant group of cancer patients With immunosuppressants, they develop viral infections with sepsis and acute kidney failure. Although the AKI in patients with sepsis is multifactorial; the primary mechanism is tubular necrosis acute after renal hypoperfusion due to circulatory failure. The early administration of Antibiotics and control of the etiological basis of sepsis are usually the pillars of prevention.
Conclusion: The prognosis of ICU patients with severe sepsis-related ARF is poor, reaching an in-hospital mortality rate of 70%. Furthermore, the presence of leukemia or lymphoma is an independent predictor of mortality in the ICU. Unfortunately, no agent has proven effective in preventing severe sepsis.
Factores de riesgo asociados a hiporrespuesta a eritropoyetina en pacientes enfermos renales crónicos en hemodiálisis que presentan anemia.
Authors: Pérez Tulcanaza Carlos Eduardo , Chonata Quinteros Jorge Fabián , Washington Vélez Jorge
Published: June 2024

Introduction: Anemia is common in patients with chronic kidney disease (CKD) and is associated with higher mortality and lower quality of life. The introduction of recombinant erythropoietin represented an advance in the management of anemia; however, an increase in the rate of cardiovascular disease and stroke was observed. Usually, anemia is partially corrected, with cases of hyporesponsiveness to treatment being found.
Methods: Observational, analytical, multicenter case-control study.
Results: Of 784 patients, 123 presented hyporesponsiveness (15.69%). The risk factors identified were: female sex (OR=2.188), age less than 50 years (OR=3.846), body mass index less than 23 kg/m² (OR=1.598), use of renin-angiotensin system blockers (OR=1. 915), albumin less than 4.0 (OR=5.286), ferritin greater than or equal to 800 ng/ml (OR=4.775), transferrin saturation index (TSI) less than 20% (OR=5.803) and parathormone greater than or equal to 500 μg/ml (OR=2.183). In the multivariate model, these variables were significant (P <0.05, R2: 0.56) except for Diabetes and BMI (P >0.05).
Conclusion: Female sex, age less than 50 years, BMI less than 23 kg/m², ARB use, low albumin, elevated ferritin, low TSI, and elevated parathormone are risk factors associated with erythropoietin hyporesponsiveness
Proteinuria en rango nefrótico en gestantes.
Authors: Castellanos Hechavarría Susana María , Gómez Rojas Yadelys , Osorio Ferrer Lissette María
Published: June 2024

Introduction: Physiological changes in pregnant women can be altered by the appearance of pathological phenomena such as proteinuria in the nephrotic range, relevant in the diagnosis of preeclampsia and glomerular disease. The objective of the present study was to describe the clinical characteristics and results of pregnant women with nephrotic proteinuria in a reference center in Cuba.
Methods: The present observational, prospective, longitudinal follow-up study, which lasted 12 weeks, was conducted at the Vladimir Ilich Lenin General Hospital in Holguín, Cuba, between October 2020 and September 2022. All pregnant women with proteinuria in the nephrotic range were registered. The variables were age, body mass index at pregnancy detection, gestational age, African descent, number of pregnancies, serum creatinine, proteinuria in 24 hours at the onset of symptoms, and clinical history. Descriptive statistics are presented.
Results: 48 patients entered the study. White, primigravida pregnant women predominated; the average age was 24.8 years. The average gestational time was 31.8 weeks, and serum creatinine was 94.8 µmol/L. The main personal medical history was arterial hypertension and systemic lupus erythematosus. There was no statistical association between the age groups and the persistence of proteinuria. Pregnant women with proteinuria before 20 weeks maintained it after 12 weeks postpartum, defining it as kidney disease. Pregnant women with previous high blood pressure had a 2.2 times higher risk of preeclampsia.
Conclusion: In both causal groups (preeclampsia and kidney disease), there were maternal-fetal complications, highlighting induced abortion, preterm birth, intrauterine growth retardation, and low birth weight.
Parada cardiorrespiratoria intradiálisis y anafilaxia a membrana de dializador como probable etiología en un paciente con inicio de terapia sustitutiva renal por enfermedad renal crónica.
Authors: Herrera Ordoñez Jorge Oswaldo , León Cabrera Oswaldo Mauricio , Sanango Reinoso Wilmer Stalin , Puertas Azanza Soraya , Sevilla Rodríguez Carmen Maricela
Published: June 2024

Introduction: During the dialysis session, hypersensitivity reactions to the dialyzer may occur. Clinically, these conditions can vary in severity, from pruritus, erythema, and facial edema to more severe conditions such as dyspnea, bronchospasm, tachypnea, cyanosis, shock, and cardiac arrest. We present an unusual case of repeated anaphylactic shock, possibly caused by the use of a dialyzer with a helixone membrane.
Clinical case: 60-year-old hypertensive and type 2 diabetic woman who presented uremia with hypervolemia and underwent dialysis treatment in the hemodialysis program. During the sixth session, she witnessed cardiorespiratory arrest, with recovery of spontaneous circulation after advanced cardiopulmonary resuscitation.
Management: Required management in intensive care with intravenous nitroprusside and intubation with mechanical ventilation.
Evolution: Given a new treatment, he once again developed hemodynamic instability with hypotension at the beginning of treatment. She was transferred to the peritoneal dialysis program.
Conclusion: An anaphylactic reaction to helixone associated with hypotension and anaphylactic shock is reported.
Lactate contents in the blood of highly qualified football players during the pre-competition period
Authors: Stepanyan L. S. , Sargsyan M. R. , Asatryan M. R. , Mkrtchyan G. R.
Published: June 2024

Relevance. In the realm of elite sports, the necessity for a straightforward, lucid, and dependable assessment of adaptive resources and mechanisms cannot be overstated. Given the prevalence of near maximum loads in athletic endeavors, there exists a propensity for athletes to teeter on the brink of overtraining. The body, being a single whole, responds to any impact, including physical activity, with a set of changes in its indicators. Fundamental research in the field of sports biochemistry carried out in recent decades, and, in particular, on changes in carbohydrate, fat, and protein metabolism under the influence of various sports activities, has made it possible to widely use the parameters of energy metabolism in sports practice. Lactate analysis is a reliable tool for monitoring the training process since changes in lactate levels reflect the intensity of physical activity and the body's adaptation to stress.

The purpose of the study was to study the lactate content in the blood of highly qualified football players in the pre-competitive period. The work consists of optimizing the training process to achieve high results in competitions.

Methods. The content of lactate in the blood of highly qualified football players in the pre-competition period is being studied, which indicates the importance of this parameter in assessing their physical fitness before competitions. Lactate analysis is an important part of monitoring the training process and allows you to optimize it to achieve the highest results in competitions. To conduct blood lactate testing, a portable lactate analyzer Lactate Plus (Sports) was used.

Conclusions. Optimization of the training process provides coaches and medical personnel with information about the reaction of football player's bodies to training loads in the pre-competition period and helps adapt training programs to the individual needs of each athlete.
Statokinetic stability in athletes of different nosological groups
Authors: Bystrova M. V. , Krasnoperova T. V.
Published: June 2024

Relevance: Researchers have shown that the characteristics of postural control in open-eyed children with visual impairment were higher than in sighted children, and these data are also associated with physical activity in their free time and the age at which they started playing sports. It is possible that people with visual or hearing impairments are more effective at maintaining balance, which may explain why they achieve similar or better results in posture control tasks compared to their normally developed peers.

The aim of the study is to study the features of the statokinetic stability of athletes of three nosological groups: with hearing impairment, with visual impairment and with intellectual disabilities.

Methods and organization of research. The method of stabilometry was used: the ST-150 stability platform and the STPL program. The area of the statokinesiogram (S, mm2); the average velocity of displacement of the pressure center (V, mm/s) and the energy consumption coefficient (Ke, conl. units) were studied.

The results of the study and their discussion. When analyzing intra-group changes in athletes with hearing impairment, a significant deterioration in the function of static equilibrium was found in the test with closed eyes, which is typical for athletes with intellectual disabilities, but the results in the test with open eyes in these athletes are significantly better than in athletes with hearing impairment. Athletes with hearing impairment and athletes with intellectual disabilities have a pronounced forward asymmetry. In the sagittal plane, athletes with visual impairment have a pronounced asymmetry to the left. Normally balanced control revailed among athletes with hearing impairment. Normally balanced and proprioceptive control was revealed in athletes with visual impairment. Visual control prevailed among athletes with intellectual disabilities. The best statistical stability was revealed in athletes with intellectual disabilities, compared with athletes of the studied nosologies.

Conclusions. Thus, the features of the statokinetic stability of athletes with hearing impairment, visual impairment and intellectual disabilities were revealed.
Parasitoides de Phyllonorycter populifoliella (Treitschke, 1833) sobre Populus balsamifera L. (Salicaceae) en el oeste europeo de Rusia (Lepidoptera: Gracillariidae)
Authors: Ermolaev I. V. , Yefremova Z. A. , Trubitsyn A. V.
Published: June 2024

Fue estudiado en Izhevsk la asociación de himenópteros parasitoides asociados al minador de hojas Phyllonorycter populifoliella (Treitschke, 1833) desarrollándose sobre el álamo balsemífero (Populus balsamifera L., 1753). La asociación de parasitoides incluyen 35 especies perteneciendo a los Eulophidae (Eulophinae, Entedoninae y Tetrastichinae), Pteromalidae, Encyrtidae, Ichneumonidae y Braconidae, con 18 especies que se citan por primera vez sobre Ph. populifoliella. Sympiesis sericeicornis, Chrysocharis laomedon. Sympiesis gordius fueron los más abundantes. Mientras que S. gordius mostraba una correlación negativa con la densidad de población del minador, ninguna de las otras dos especies estaban relacionadas con la densidad de la planta del minador. Se da una idea general de las posibles causas de la baja eficacia de las reunión de parasitoides sobre la población de Ph. populifoliella.
Relación de las plantas nutricias de 29 especies de Lepidoptera mediterráneas en ecosistemas forestales revelados por el Código de barras de ADN (Insecta: Lepidoptera)
Authors: Hausmann A. , Scalercio S.
Published: June 2024

Se colectaron un total de 45 larvas de Lepidoptera en etanol de 16 especies de plantas en el sur de Italia, requiriendo sólo unas pocas horas de trabajo de campo. La identificación fue llevada a cabo con el sistema de código de barras de ADN revelando la relación con las plantas  nutricias de 29 especies de Lepidoptera. Los autores proponen un enfoque a mayor escala usando este método rápido y eficaz y animando a otros entomólogos a sumarse al equipo.
FENOMENOLOGIA DA RELIGIÃO:
Authors: Souza Mailson Fernandes Cabral de
Published: June 2024

O texto que apresentamos é o primeiro capítulo do livro The meaning of religion: lectures in the phenomenology of religion, de William Brede Kristensen (1867-1953). Essa obra, publicada originalmente no ano de 1960 pela editora holandesa Martinus Nijhoff, é uma tradução do holandês para o inglês de parte das preleções feitas por Kristensen no período em que atuou como professor de Ciência da Religião na Universidade de Leiden (1901-1937), na Holanda, sendo o sucessor da cátedra anteriormente ocupada por Cornelis Petrus Tiele (1830-1902). Em The meaning of religion, Kristensen traz uma importante contribuição para a discussão teórico-metodológica da Ciência da Religião, apresentando uma abordagem fenomenológica não-essencialista, atenta ao valor que a religião assume para o próprio crente – um contraponto às abordagens fenomenológicas dominantes de seu tempo, centradas na questão da essência da religião –, além de elaborar uma organização própria do que entende ser as frentes de trabalho da Ciência da Religião e suas competências no interior dessa disciplina. O capítulo inicial dessa obra recebeu o nome de General Introduction, sendo dividido em três seções: a) Phenomenology of Religion; b) The “Holy”; c) The two types of religious orientation. Em nossa tradução deste texto, julgamos ser mais coerente apresentá-lo com o título de Fenomenologia da Religião, seguido de introdução geral, conservando a sua subdivisão em três seções.
Licenciatura em Computação
Authors: Raabe André , Nunes Daltro José , Falcão Taciana Pontual
Published: June 2024

Este artigo resume as características dos Cursos de Licenciatura em Computação no Brasil.
The Role of Coronary CT Angiography in Chronic Total Occlusion Coronary Intervention
Authors: Laksono Sidhi , Maya Suryana Nana
Published: June 2024

Context: The application of coronary computed tomography angiography (CCTA) is increasingly being recognized for its role in diagnosing and ruling out coronary artery disease (CAD). This editorial letter discusses the usefulness of CCTA in planning for chronic total occlusion percutaneous coronary intervention (CTO PCI). Evidence Acquisition: We searched for articles using Google Scholar and the PubMed Database. The keywords used were "Coronary CT Angiography (CCTA)," "Chronic Total Occlusion (CTO) intervention," "pre-procedural CTO PCI," and "post-CTO interventions." The articles included in the review were published between 2013 and 2023. Results: Regarding pre-procedural planning for the revascularization of chronic total occlusions (CTOs), there is significant interest in the ability of CCTA to visualize and analyze coronary atherosclerotic plaque. Additionally, CCTA can provide three-dimensional coronary vessel imaging. Following post-CTO intervention, CCTA is utilized to determine whether the formation of new channels and plaque remodeling will improve the chances of future successful interventions. Conclusions: CCTA allows for the precise assessment of anatomical features without invasive procedures, making the diagnosis of CAD easier. The technology is advancing rapidly, with new scanners offering higher resolution, better-quality images, and reduced radiation exposure.
Effect of Home-Based Pulmonary Rehabilitation on Pulmonary Fibrosis
Authors: Saha Rashmita , Singh Vijay Pratap , Samuel Stephen Rajan , Acharya K Vishak , Acharya Preetam Rajgopal , Kumar K. Vijaya
Published: June 2024

Background: Pulmonary fibrosis is a chronic, progressive lung condition that involves lung tissue scarring and thickening. The effects of home-based pulmonary rehabilitation (PR) in post-covid pulmonary fibrosis (PCPF) and other forms of fibrosis together have not been evaluated. This study aims to evaluate the effectiveness of home-based pulmonary rehabilitation on pulmonary function, functional capacity, and health-related quality of life in people with pulmonary fibrosis (post-COVID pulmonary fibrosis, pulmonary fibrosis secondary to pulmonary tuberculosis (TB), pulmonary fibrosis secondary to interstitial lung disease (ILD), pulmonary fibrosis secondary to bronchiectasis). Methods: A single-group pretest–posttest experimental study was performed after recruiting 98 pulmonary fibrosis subjects from K.M.C hospitals. After being screened for the inclusion and exclusion criteria, 45 subjects were analyzed, and 6 subjects were lost to follow-up.  A home-based pulmonary rehabilitation program was carried out for 8 weeks (warm-up, stretching exercises, aerobic exercise, strength training for upper limb and lower limb, breathing exercises mainly involved; others: energy saving techniques, controlled coughing techniques, dyspnea relieving positions). The program was supervised via weekly phone calls. Pulmonary function (Pulmonary function test), exercise capacity (6-minute walk test), dyspnea (modified Borg scale), and health-related quality of life (SF-36) were evaluated before and after the intervention. During the enrollment and after the 6-minute walk test, saturation of peripheral oxygen (SPO2) level was also evaluated pre-intervention and after the 8-weeks program. Results: Pulmonary function [FVC(L) t = -12.52, p<0.05; FEV1(L) t = -2.56, p<0.05; FEV1/FVC t = 7.98, p<0.05 and DLCO (ml/min/mmHg) t = -5.13, p<0.05], 6MWD [MD 88.66; p<0.05] and HRQOL measured by SF-36 scores (p<0.05) were improved significantly. Both the baseline SPO2 level before the 6MWT [MD 1.07, p<0.05] and the SPO2 level after the 6MWT [MD 1.16, p<0.05] showed a significant improvement. The rating of perceived exertion(dyspnea) [MD 1.30, p<0.05] was reduced significantly after the 8-week program. Conclusion: Our study shows that home-based pulmonary rehabilitation is an effective option for improving lung function and physical functional capacity by reducing dyspnea perception and improving the saturation of peripheral oxygen (SPO2) level, and enhancing the quality of life in people with pulmonary fibrosis.
Fighting for Freedom: Liberal Argumentation in Culture War Rhetoric
Authors: Miller Eric C. ,   Religious Communication Association
Published: June 2024

This essay analyzes the deployment of freedom and liberty as premises in orthodox culture war argumentation. Specifically, it suggests that recent decades have been host to a marked shift in social issue debates, whereby formerly religious arguments have adopted an increasingly secular, liberal tenor. Though ostensibly concerned with moral questions, activists and interest groups have sought to appropriate the mantle of American freedom, thus fortifying their positions amid the shared ideals of liberal democracy. A timely case study is found in contemporary opposition to same-sex marriage. Here as elsewhere, religious elites who had formerly framed their public statements in accusatory moralreligious terms now increasingly claim to stand in defense of free speech and free religious expression. Though at times justified, this position indicates a sort of rhetorical backpedaling whereby religious speakers defend the right to hold unpopular views rather than attempting to defend the views themselves. I conclude by suggesting a religious politics in the broad sense of the term, advising religious advocates to return to a public practice of their faith that rejects political ambition.
First “What Is Knowing?” Then “How’d They Know?”: Epistemological and Phenomenological Considerations in the Study of Direct Divine Communication (DDC)
Authors: Sigler J. E. ,   Religious Communication Association
Published: June 2024

Two studies are presented. The first derives an eight-item Model of Academic Criteria for Direct Divine Communication (MACDDC) from the few existing empirical studies of the phenomenological experience of direct divine communication (DDC). Four serious limitations of the MACDDC, arising from biases in DDC research, are discussed. The second study argues that phenomenological DDC research cannot be fruitfully conducted until agreement is reached on principles for the inclusion/exclusion for study of experiences reported as DDCs. Four epistemological principles, derived from previous literature and interviews with 32 Catholic women religious, are suggested as a starting point for scholarly discussion.
The Unconventional Postmodern Voice of Religion in André Øvredal’s Trollhunter
Authors: Hohle Philip ,   Religious Communication Association
Published: June 2024

Has the conventional voice of religion been silenced in postmodern film? The emancipating language of postmodernism has found a home among independent filmmakers, those artists who are less constrained by the blockbuster orthodoxy and profit-centered penitence of the mega-studio. Now their alternate rhetorical voices are frequently heard in the mainstream. In some ways the subject of religion is given new breath, as the taboos and talismans of a previous generation are put aside in favor of a less institutionalized version of the role of religion in life. André Øvredal’s Trollhunter is a postmodern take on a pre-modern folktale. The discovery of opposing rhetorical situations in this film creates opportunities to analyze deeper religious meanings in the narrative and the exigency from which it arises and invites a response.
Muslim Immigration to India: The Influence of Religiosity on the Perception of Immigrant Threat
Authors: Croucher Stephen M. , Juntunen Senna , Zeng Cheng ,   Religious Communication Association
Published: June 2024

This study analyzed the relationships between religiosity, threat, and intergroup contact between Hindus and Muslim immigrants in India. Results showed the following. First, Hindus with high religiosity were more likely to perceive more threat from Muslim immigrants. Second Hindus with high religiosity were more likely to have less contact with Muslim immigrants. Finally, intergroup contact was negatively correlated with the perception of threat from Muslim immigrants. Theoretical implications related to intergroup contact, religiosity, and group vitality are discussed.
Rhetorical Functions of the Bible in American Presidential Discourse, 1977–2013: A Taxonomy
Authors: Medhurst Martin J. ,   Religious Communication Association
Published: June 2024

This essay identifies nine distinct functions that use of the Bible serves for U.S. presidents. A method for isolating biblical quotations and allusions is first identified and then applied to the presidential discourse of Jimmy Carter, Ronald Reagan, George H. W. Bush, Bill Clinton, George W. Bush, and Barack Obama. Each of the nine functions is illustrated, and the implications of their deployment for presidential rhetoric and the American polity are discussed.
Communicating about Communicating with Kami (Deities): An Ethnographic Study of WASHINOMIYA SAIBARA KAGURA
Authors: Sakurai Takuya ,   Religious Communication Association
Published: June 2024

Kagura is one of the oldest forms of Shinto folk performing arts in Japan. Performed as part of local religious festivals, it is considered to be a means of communicating with kami (deities). This article offers an ethnographic study of WASHINOMIYA SAIBARA KAGURA to explore the communicative dimensions of Shinto. The purpose is twofold: (a) to seek religious conditions that allow the Japanese to communicate about kami; and (b) to add an East Asian cultural insight into our understanding of intercultural communication and religion. The study demonstrates the ways the members of the kagura group communicate about the kagura and how the group shares the kami, focusing on the interaction during the kagura practices.
Measurable Residual Disease Analysis by Flow Cytometry and Correlation With Molecular Measurable Residual Disease in Acute Promyelocytic Leukemia: A Real-World Prospective Study
Authors: Wen Zhihao , Xue Xinran , Li Shuhua , Liu Yu , Jin Yongmei , Jiang Nenggang , Liao Hongyan
Published: June 2024

Context.—

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia distinguished by its rapidly progressive and fatal clinical course. Measurable/minimal residual disease (MRD) monitoring is vital for the prognosis and clinical management of acute myeloid leukemia.

Objective.—

To examine the immunophenotypes of the residual leukemic cells, evaluate the performance of multiparametric flow cytometry (FCM) measuring MRD, and compare it with molecular monitoring in patients diagnosed with APL.

Design.—

Two hundred seventy-seven patients with APL were enrolled. Immunophenotypes were prospectively analyzed by a 1-tube-10-color antibody panel via FCM. MRD of APL with PML::RARα was detected by real-time quantitative polymerase chain reaction (RQ-PCR). The clinical value of MRD as an indicator of survival was also examined.

Results.—

APL showed 5 distinct patterns of residual leukemic cells, based on CD45 and side-scatter scattergram, all with CD9 positivity and a previously unrealized loss of CD117. FCM-based MRD evaluation showed a concordance rate of 87.7% with PCR. At the end of the consolidation therapy, MRD measured by both PCR and FCM could differentiate patients with longer and shorter overall survival (OS) (P = .04 and P = .03, respectively). Patients with APL variant had a shorter OS than patients with APL who harbored PML::RARα (P < .001).

Conclusions.—

CD9 is a reliable marker to differentiate residual leukemic cells from normally differentiating myeloid cells. FCM demonstrated a high comparability to PCR-MRD and an excellent performance in predicting OS, and thus could potentially be used as a routine indicator in the clinical management of patients with APL.
Conventional Cytogenetic Analysis of Constitutional Abnormalities: A 20-Year Review of Proficiency Test Results From the College of American Pathologists/American College of Medical Genetics and Genomics Cytogenetics Committee
Authors: Boles Brittney , Gardner Juli-Anne , Rehder Catherine W. , Levy Brynn , Velagaleti Gopalrao V. , Toydemir Reha M. , Sukov William R. , Larson Daniel P. , Cao Yang , Mixon Christopher , Vanderscheldon Rachel K. , Zou Ying S. , Astbury Caroline , Tsuchiya Karen D. , Peterson Jess F.
Published: June 2024

Context.—

The joint College of American Pathologists/American College of Medical Genetics and Genomics Cytogenetics Committee works to ensure competency and proficiency of clinical cytogenetics testing laboratories through proficiency testing programs for various clinical tests offered by such laboratories, including the evaluation of constitutional abnormalities.

Objective.—

To review and analyze 20 years of constitutional chromosome analysis proficiency testing results (2003–2022), primarily utilizing G-banded karyograms.

Design.—

A retrospective review of results from 2003 through 2022 was performed, identifying challenges addressing constitutional disorders. The chromosomal abnormalities and overall performance were evaluated.

Results.—

A total of 184 cases from 161 proficiency testing challenges were administered from 2003 through 2022. Challenges consisted of metaphase images and accompanying clinical history for evaluation of numerical and/or structural abnormalities. Of the 184 cases, only 2 (1%) failed to reach an 80% grading consensus for recognition of the abnormality. Both cases illustrated the limitations of correctly characterizing some chromosomal abnormalities, including recombinant chromosomal abnormalities and isochromosome identification. In addition, 2 cases failed to reach a consensus for nomenclature reporting: 1 with an isochromosome and another with a duplication.

Conclusions.—

This 20-year review illustrates the high rate of competency and proficiency of cytogenetic laboratories in the correct identification of constitutional chromosome abnormalities.
JOMINI VE CLAUSEWITZ’İN SAVAŞ OLGUSUNA BAKIŞ AÇILARININ KARŞILAŞTIRMALI ANALİZİ
Authors: Öcal Arslan Şeyda
Published: June 2024

Eski çağlardan günümüze kadar birçok örnek verebilmekle beraber Antoine-Henri baron de Jomini ve Carl von Clausewitz kaleme aldıkları eserlerle önemli savaş teorisyenleri olarak kabul edilmektedir. Bu çalışmada Napolyon döneminde yaşamış olan Jomini’nin 1838 yılında yayımlanan “Savaş Sanatı’nın Ana Hatları” eseri ve Clausewitz’in 1832 yılında yayımlanan “Savaş Üzerine” eseri temelinde iki teorisyenin metodoloji, teoride savaş kavramı ve pratikte savaşın strateji ve taktiksel uygulamaları üzerine karşılaştırmalı analizi yapılmıştır. Çalışmanın temel amacı iki teorisyenin savaş kavramına bakış açılarını teoride ve uygulamada nasıl ele aldıklarını incelemek, pratikte strateji ve taktik uygulamaları nasıl yorumladıkları üzerine karşılaştırmalı bir analiz yapmaktır. İkisi de Napolyon döneminde yaşamasına rağmen farklı geçmiş yaşam ve bakış açılarına sahip olmalarından dolayı teorik olarak savaş kavramını kendi perspektiflerinden yorumlamışlardır. Bu bağlamda çalışma Jomini ve Clausewitz’in çağdaş teorisyen olarak farklı hususlar üzerinden savaşın teorisini açıklamalarının günümüzde hala savaş çalışmalarına katkı sunarak değerini koruduğunu açıklamayı hedeflemektedir. Çalışma kapsamında iki teorisyen arasında metodolojik, savaş teorisine yaklaşım, strateji, taktik, düşüncelerinde etki bırakan unsurlar, komutanın rolü, savaşın bir bilim mi yoksa sanat mı olduğu hususlarında farklılıklar olduğu tespit edilmiştir. Çalışma boyunca yapılan karşılaştırmalı analiz göstermektedir ki iki teorisyen de evrensel bir savaş teorisi ortaya koyarak, değişen karakteriyle birlikte savaş kavramının tekrar tekrar incelenmesine de ilham kaynağı olmuşlardır. Savaşın karmaşıklığı karşısında eserleri birbirini tamamlamakta ve savaşın somut olduğu kadar soyut yönlerine de kapsamlı bir bakış sağlamaktadır.
Shear strength of reinforced concrete beam with embedded steel trusses
Authors:   , Pormeuanpieng Khonesavanh
Published: June 2024

A steel truss might be embedded in reinforced concrete (RC) beam to enhance strength and stiffness of the beam under extremely high force demands within limited space. Shear strength of such beam construction has not yet been well investigated. This research aims to predict shear strength of RC beam with embedded steel trusses. Several approaches were considered: 1) conventional shear formula; 2) strut-and-tie model (STM); and 3) finite element (FE) method. Shear strength formula and STM follow ACI 318 (2014) and AASHTO LRFD (2012). These approaches were implemented, and results were compared with reference to shear strength test results of physical specimens by Zhang et al. (2016). Four beam specimens were considered including RC beam with and without embedded truss and variations of stirrup reinforcements. Nonlinear finite element analysis was carried out to study on the shear capacity provided by concrete, stirrups and steel trusses. In FE models, concrete and steels were assumed as perfectly bonded. STM per AASHTO provides a better estimate of shear strength than other approaches and more suitable to be used in design of such beams. FE models over-estimate shear strength of the reinforced concrete beam with embedded steel trusses. More investigation should be conducted to obtain better estimation of shear strength by FEM before it can be used in practice.
Roles of WOx on Pt/γ-Al2O3 catalysts on the prevention of Pt metal sintering during hydrogenolysis of glycerol to 1,3-propanediol
Authors:   , Limsoonthakul Poonnapa
Published: June 2024

Hydrogenolysis of glycerol to produce 1,3-propanediol is the most effective reaction which conversing excess glycerol from biodiesel production to high-value-add product; especially, 1,3-propanediol. A solid catalyst which generally used as selective to 1,3-propanediol production is Pt-based catalyst with γ-Al2O3 supporter which was prepared by wet impregnation method in this study. Although hydrogenolysis of glycerol reaction has been carried out under mild conditions: 140 °C and 5 bar of initial H2 pressure, the deactivation of non-reduced Pt/γ-Al2O3 catalyst is observed. To investigate the deactivation of the catalyst, the used Pt/γ-Al2O3 and Pt/WOx/γ-Al2O3 catalysts were characterized by N2-physisorption, ICP-OES, SEM-EDX, XRD, Py-IR, TPO and FTIR. In this study, deactivations are leaching, sintering and coke formation on both Pt/γ-Al2O3 and Pt/WOx/γ-Al2O3 catalyst during the hydrogenolysis of glycerol in liquid phase. WOx can hinder the sintering of Pt metal and retard the coke formation on the catalyst surface. Furthermore, the existence of WOx on Pt/WOx/γ-Al2O3 catalysts can also improve catalytic activity for glycerol conversion. Moreover, Pt/WOx/γ-Al2O3 catalysts can significantly increase the selectivity of 1,3-propanediol beyond 1,2-propanediol. Nevertheless, the stability of Pt/WOx/γ-Al2O3 catalyst is better than that of Pt/γ-Al2O3 catalyst indicated by lower conversion drop of the used catalyst after the first hydrogenolysis of glycerol. Consequently, the addition of WOx on Pt/γ-Al2O3 catalyst makes appropriated Pt-based catalyst performing in hydrogenolysis of glycerol in terms of higher activity, the selectivity of wanted 1,3-propanediol and stability of the catalyst.
Development of an Integrated Microfluidic System for Cell Sorting and Trapping—Considering Sorting Efficacy and Cell Viability
Authors:   , Suwannaphan Thammawit
Published: June 2024

This study is divided into two phases. The first phase is about the investigation of cell viability and damage of white blood cells after sorting in both a spiral microchannel and contraction and expansion array (CEA) at appropriate flow rates for cell separation. Three techniques such as Trypan Blue staining, Scanning Electron Microscopy (SEM) and Wright-Giemsa staining are employed in the experiments. After flowing the sample through a whole setup of spiral microchannel at 2 ml/min, 85% of cells are viable while 30% of cells are significantly deformed and 2% of cells are seriously damaged in their intracellular structures. In CEA experiments, they are 89, 12 and 14%, respectively, at 0.3 ml/min. Considering computational results of flow dynamics at the same conditions, shear stress dominates over extensional stress in the spiral microchannel covering the entire length of the channel close to the walls with long exposure time. This may cause cell death and significant deformation. On the other hand, extensional stress dominates in the CEA and occurs at the corner where the cross-section of the flow channel changes. Despite of short exposure time due to high flow rate, the extensional stress with extremely high magnitude covers almost entire the cross-section of the flow channel. It potentially causes intracellular damage to the cells, and cell death. Therefore, the spiral microchannel and CEA cause cell damage in different ways due to the different types of stresses. The second phase demonstrates the integrated microfluidic device combining with the spiral microchannel and triangular wells together. The system is tested with microbeads and mast-cell-tumor (MCT) cells. When the flow rate increases in the range of 0.2, 0.5, 1 and 2 ml/min, the 10, 15 and 20 µm microbeads gradually move towards the inner wall at the outlet of the spiral channel, and comes in the 3rd, 2nd and 1st chamber of microwells. At the flow rate of 0.5 ml/min, the maximal percentage of the trapping for 15 µm microbeads is found at 80% in the 3rd chamber. Regarding this reason, this flow rate is used in the cell experiments since the size of MCT cells is about 15 µm. When sorting the MCT cells at this flow rate, cell viability is 74%. After culturing in the microwells for three days, cell viability is 68% when the continuous flow of nutrient is fed at 10 µl/hr. The results show the feasibility of the developed system in biological applications.
Learning-based approach for visual quality enhancement on high efficiency video coding standard
Authors:   , Chen Sovann
Published: June 2024

High Efficiency Video Coding (HEVC) has dramatically enhanced the coding efficiency compared to the previous video coding standard, H.264/AVC. However, the existing rate control updates its parameters according to a fixed initialization, which can cause error prediction of bit allocation to each coding tree unit (CTU) in frames. In this work, a learning-based mapping between rate control parameters and video contents is proposed to achieve an accurate target bit rate and good video quality. The proposed framework contains two main structural codings, including spatial and temporal coding. We initiate an effective learning-based particle swarm optimization for both spatial and temporal coding to determine the optimal parameters at the CTU level. For temporal coding at the picture level, we introduce semantic residual information into the parameter updating process to regulate the bit correctly on the actual picture. Experimental results indicate that the proposed algorithm is effective for HEVC and outperforms the state-of-the-art rate control in the HEVC reference software (HM-16.10) by 0.19 dB on average and up to 0.41 dB for low delay P coding structure.
The deactivation study of titanium dioxide catalyst in thermochemical processes via density functional theory
Authors:   , Ngamlaor Chinanang
Published: June 2024

In this study, the investigation of catalytic deactivation of TiO2 by coking was performed using DFT. The effect of the Hubbard U, which was varied as U equal 4 to 6 eV and Van der Waal corrections on electronic properties were also investigated. The effect of temperature in the range of 400-1000°C was also studied. This work aims to understand relatives of coke formation, oxygen vacancy, phase transformation. The increment of the Hubbard U values provide a more accurate quantitative cited by the energy gap from the experimental investigation, the appropriate U value of the A-TiO2 (101) is 4 eV, while the R-TiO2 (110) is 6 eV. The coke formation of C1 is strongly adsorbed on the A-TiO2 (101) surface, while on the R-TiO2 (110) surface, C2 is strongly adsorbed. For oxygen vacancy on coke formation, C2 coke is strongly adsorbed on O-vac A-TiO2 (101) and O-vac R-TiO2 (110) surfaces. This can be suggested that the defect surface is more active than the perfect surface which may lead to higher stability of coke deposition. For the effect of temperature, the interaction between cokes and surfaces becomes weaker when the temperature is increased. Moreover, during the thermochemical process, the TiO2 catalyst can transform anatase to the rutile phase. It is suggested that the coke formation on the R-TiO2 (110) surface is more severe than on the A-TiO2 (101) surface.
The deactivation of gamma-alumina based catalyst during aqueous phase reaction using density function theory
Authors:   , Aphichoksiri Phakaorn
Published: June 2024

Nowadays, biomass conversion has become a more attractive process to produce fuels and various high-value chemicals from biological materials. From many kinds of catalysts, the metal-supported gamma-alumina (γ-Al2O3) is a widely used catalyst for various transformation processes, especially in the aqueous phase reaction. Typically, coke formation on γ-Al2O3 causes catalyst deactivation in the thermal reaction process. Moreover, incorporation of aqueous phase medium initiates hydroxylation of γ-Al2O3 and phase transformation of γ-AlOOH, leading to the catalyst deactivation. Not only coke formation and phase transformation are the cause of catalytic deactivation, but the oxygen vacancy, changing the activity of the catalyst, should also be the cause of the deactivation of γ-Al2O3. To understand the interplay between coke formation, oxygen vacancy, and phase transformation, the coke formation on the γ-Al2O3 catalyst has been theoretically investigated using density functional theory (DFT). Starting with the coke formation on the γ-Al2O3 surface, the coke is strongly chemisorbed, and the forming higher coke prefers a cyclic form to the aliphatic on the γ-Al2O3 surface. Afterward, the effects of partial hydroxylation on γ-Al2O3 forming OH/γ-Al2O3 and full hydroxylation until phase transformation forming γ-AlOOH on coke formation were also investigated. Hydroxylation of the γ-Al2O3 surface can suppress the interaction between coke and the surface. However, the covered surface with the hydroxyl group promotes coke polymerization, as evidenced by the relative formation energy. In addition, the effect of oxygen vacancy on coke formation was investigated. The presence of oxygen vacancy has a remarkable impact on the coke formation and makes the elimination more difficult. Moreover, the thermal effect was also investigated at 373 to 773 K. The increasing temperature diminishes the adsorption strength, leading to the weak interaction between coke and the surface. Finally, the coke dimerization has been explored to predict the feasibility of coke evolution on the γ-Al2O3, demonstrating that the dimerization is spontaneous and can occur with the energy barrier of 1.89 eV.
Parking problems and policies in Bangkok: issues, causes, and implications
Authors:   , Chullabodhi Chakaphan
Published: June 2024

Parking policies are integral to promoting sustainable urban mobility and enhancing a city's livability as they can shift people's movement toward more sustainable modes. However, Bangkok still lacks a concrete parking policy. The existing one consists primarily of regulations and standards that help reduce traffic congestion, albeit without well-defined policy objectives. This study examines the current problems of on-street and off-street parking policies, investigates the root causes of parking issues, and establishes a parking policy that supports the city's development of sustainable mobility. We used a modified conceptual framework comprising the Iceberg Model of analysis and the Political Economics Analysis framework. The data were collected through various techniques, including a field survey, a license plate survey, documentary research, and semi-structured in-depth interviews. The finding of this study demonstrates, through empirical evidence, that the existing on-street and off-street parking policy has created a number of challenges that have a negative impact on society. The results also reveal that several factors, including urban and transportation planning, political-economic, institutional, and legal frameworks, policy strategy and planning, operational management, and the mental model of stakeholders, are the root causes of these parking problems. This study proposes parking policy recommendations and implications for policymakers and transport planners to support parking reform in Bangkok and other developing countries.