bluuebunny/crossref_metadata_2025 huggingface dataset:
Blood integrated indicator of oxidative stress in infants born to HIV-infected mothers
Authors:   Сientific Сentre for Family Health and Human Reproduction Problems, Irkutsk, Kurashova N.A. , Petrova A.G. ,   Сientific Сentre for Family Health and Human Reproduction Problems, Irkutsk, Vanyarkina A.S. ,   Сientific Сentre for Family Health and Human Reproduction Problems, Irkutsk, Rychkova L.V. ,   Сientific Сentre for Family Health and Human Reproduction Problems, Irkutsk, Darenskaya M.A. ,   Сientific Сentre for Family Health and Human Reproduction Problems, Irkutsk, Moskaleva E.V. ,   Сientific Сentre for Family Health and Human Reproduction Problems, Irkutsk, Kolesnikova L.I. ,   Сientific Сentre for Family Health and Human Reproduction Problems, Irkutsk
Published: December 2024

A single-center cross-sectional study was conducted from March 2020 to January 2021 and included 142 neonates born with a gestational age of more than 37 0/7 weeks. The aim of the work was an individual assessment of the oxidative stress index (OSI) in newborns of HIV-infected mothers. Materials and methods: the state of the LPO–AOD system was assessed by determining the content of lipid peroxidation oxidation substrates with conjugated double bonds (DB), diene conjugates (DC), ketodienes and conjugated trienes (KD and CT), TBA-active products in the blood (TBA-AP), retinol, α-tocopherol, reduced (GSH) and oxidized glutathione (GSSG), superoxide dismutase (SOD) activity. OSI was used to evaluate differences in lipid peroxidation processes in HIV-exposed uninfected newborns. Results: The index of oxidative stress in the group of HIV-exposed uninfected newborns was detected 1.98 times higher compared to healthy newborns and was 2.5 and 1.26, respectively. The value of the oxidative stress coefficient indicates a significant imbalance in the LPO-AOP system reflecting the enhancement of the lipid peroxidation processes. An increase in the concentration of substrates and products of peroxidation leads to the destruction of lipids, and, consequently, to the degradation of the cell membrane complex. Conclusion: The integral oxidative stress index is recommended as a general indicator that characterizes the level of lipid peroxidation products and antioxidant protection factors in a particular group. Also, OSI is more sensitive indicator than separated components of the system, which objectively represents the LPO–AOD system malfunctioning, and provides the comprehensive view to the both lipid peroxidation processes and the level (effectiveness) of protective factors. To summarize, the results of the study point to the need to further investigations aimed to determination of prognostically significant markers in PVEN, which could be involved or could indicate the pathological processes both in the early neonatal period and in the later stages of infant development.
Keywords: newborns, HIV-infected pregnant women, HIV infection, oxidative stress, integral index.
Navigation-assisted surgery for pyrophosphate arthropathy of the temporomandibular joint
Authors: Nazarov V.V. , Chukumov R.M. , Ilyin M.V. , Ostaev Ju.A. , Okshin D.Ju. , Ektova A.P. , Rogozhin D.V. , Linde N.N. , Batalov A.I. , Tlisova M.N. , Spirin D.S. , Cherekaev V.A. , Matuev K.B. , Svyatoslavov D.S. , Reshetov I.V.
Published: December 2024

Background. Pyrophosphate arthropathy (calcium pyrophosphate dihydrate deposition disease) refers to rare deposition disorders with the onset of the disease after 55 years, manifested by the formation and deposition of calcium pyrophosphate crystals in the joint area, which leads to aseptic inflammation of an immune nature. Clinical manifestations of calcium pyrophosphate accumulation disease are similar to those of various degenerative and inflammatory joint lesions, as well as tumors. With the progression of pyrophosphate arthropathy, surgical treatment is required, which includes both histological verification and complex reconstructive interventions involving a neurosurgeon and a maxillofacial surgeon. Case description. We present a clinical case of pyrophosphate arthropathy of temporomandibular joint with a spread to the middle cranial fossa and propose an algorithm for the treatment of such lesions. Conclusion. Modern computer modeling technologies and experience in the use of various materials for allotransplantation make it possible to perform one-stage surgical treatment with resection and reconstruction of the temporomandibular joint. However, further studies are needed to assess the long-term results of the use of personalized implants in order to assess tissue reactions, the frequency of infectious complications, and prosthesis migration.

Актуальность. Пирофосфатная артропатия – ПФА (болезнь накопления пирофосфата кальция) относится к редким заболеваниям накопления с дебютом заболевания после 55 лет, проявляется образованием и депонированием кристаллов пирофосфата кальция в области сустава, которое приводит к асептическому воспалению иммунного характера. Болезнь накопления пирофосфата кальция имеет схожую клиническую картину с различными дегенеративными и воспалительными заболеваниями суставов, а также с опухолевым поражением. При прогрессировании ПФА требуется хирургическое лечение, которое необходимо как для гистологической верификации процесса, так и для сложной реконструктивной операции с участием нейрохирурга и челюстно-лицевого хирурга. Клиническое наблюдение. Описан случай ПФА височно-нижнечелюстного сустава с распространением на среднюю черепную ямку и алгоритм лечения подобных поражений. Заключение. Современные технологии компьютерного моделирования и опыт применения различных материалов для аллотрансплантации позволяют выполнить одноэтапное хирургическое лечение с резекцией и реконструкцией височно-нижнечелюстного сустава. Однако необходимы дальнейшие исследования для оценки отдаленных результатов применения персонализированных имплантов с целью оценки тканевых реакций, частоты инфекционных осложнений и миграций протезов.
Treatment of young adults with oral cancer: current state and outlook (The Consortium «Etiology and pathogenesis of oral cancer in young adults»). Part 2
Authors: Fedorova I.K. , Kulbakin D.E. , Kolegova E.S. , Patysheva M.R. , Denisov E.V. , Polyakov A.P. , Mordovsky A.V. , Rebrikova I.V. , Kaprin A.D. , Averinskaya D.A. , Romanova M.E. , Shatalov P.A. , Shegay P.V. , Kudashkina D.S. , Yakovleva L.P. , Vyalov A.S. , Kropotov M.A. , Tsiklauri V.T. , Saprina O.A. , Sukortseva N.S. , Samoilova S.I. , Reshetov I.V. , Choinzonov E.L.
Published: December 2024

The review is devoted to the current state and prospects for the treatment of young adults with oral cancer. The article analyzes the possible methods of treatment for this category of patients: immunotherapy, radiation and phototherapy, hyperthermia, surgical treatment, and also discusses the prospects for antibiotic therapy and regulation of the epigenetic landscape of oral cancer in young adults.

Обзор посвящен современному состоянию и перспективам терапии молодых пациентов с раком полости рта. В статье дан анализ возможных методов лечения больных данной категории: иммунотерапия, лучевая и фототерапия, гипертермия, хирургическое лечение, а также обсуждены перспективы антибиотикотерапии и регуляции эпигенетического ландшафта рака полости рта у молодых пациентов.
Experience with a blue diode laser with a wavelength of 445 nm in otorhinolaryngology
Authors: Ovchinnikov A.Yu. , Edzhe M.A. , Bakotina A.V. , Atlashkin D.N.
Published: December 2024

The 445-nm blue laser has only recently come into surgical practice for the treatment of diseases of the ENT organs. The article describes experience of using the 445-nm Wolf TruBlue laser during planned surgical interventions in the otorhinolaryngology departments of the University Clinic of the A.I. Evdokimov MSUMD. The 445-nm blue laser is a lightweight compact laser operating with a fiber light guide, combining the possibility of contact and remote tissue exposure, with a pronounced photoangiolytic and hemocoagulating effect. The study of the prospects for its further application in endoscopic endonasal surgery of the paranasal sinuses and the skull base, ear microsurgery, and endolaryngeal surgery is currently of scientific interest.

Диодный лазер синего спектра с длиной волны 445 нм в хирургическом лечении заболеваний ЛОР-органов используется сравнительно недавно. В статье описан опыт использования лазера Wolf TruBlue 445 нм при проведении плановых оперативных вмешательств в отделениях оториноларингологии университетской клиники МГМСУ им. А.И. Евдокимова. Диодный лазер синего спектра с длиной волны 445 нм – это легкий компактный лазер, работающий с волоконным световодом, сочетающий возможность контактного и дистанционного воздействия на ткань, обладающий выраженными фотоангиолитическим и гемокоагулирующим эффектами. Изучение перспективы его дальнейшего применения в эндоскопической эндоназальной хирургии околоносовых пазух, основания черепа, микрохирургии уха и эндоларингеальной хирургии в настоящее время представляет научный интерес.
Правовая основа деятельности добровольческих формирований в Российской Федерации
Authors: Попова Н.Ф.
Published: December 2024

Цель исследования — оценка качества правового регулирования деятельности добровольческих формирований в СССР и современной России в части, касающейся выполнения боевых задач, денежного, медицинского и материального обеспечения добровольцев. Автором осуществлен анализ нормативных правовых актов и литературных источников по рассматриваемому вопросу, охарактеризованы формы добровольных объединений в годы Великой Отечественной войны и при проведении специальной военной операции. Делаются выводы о том, что основной причиной массовости добровольческого движения является патриотический порыв граждан по защите страны от внешних врагов: также определенную роль играет высокая степень социальной и материальной защищенности добровольцев и членов их семей, закрепленная в действующем законодательстве.

The purpose of the study is to assess the quality of legal regulation of the activities of volunteer formations in the USSR and modern Russia in terms of the performance of combat missions, monetary, medical and material support for volunteers. The author carried out an analysis of regulatory legal acts and literary sources on the issue under consideration, and characterized the forms of voluntary associations during the Great Patriotic War and during a special military operation. It is concluded that the main reason for the massiveness of the volunteer movement is the patriotic impulse of citizens to protect the country from external enemies: the high degree of social and material security of volunteers and members of their families, enshrined in the current legislation, also plays a certain role.
Эффективное управление имуществом государства: финансовые и правовые аспекты
Authors: Дадаев З.А.
Published: December 2024

Рассматриваются важнейшие аспекты управления государственным имуществом. Анализируются правовые и организационные проблемы, связанные с управлением государственным имуществом, среди которых установление и передача права собственности, регулирование и контроль за использованием имущества, а также юридическая защита государственных активов. Оценивается значимость грамотного и эффективного распоряжения имуществом, находящимся в государственной собственности. Устранение пробелов в законодательстве, а также поиск новых подходов к вопросу управления государственным имуществом рассматриваются как один из инструментов восполнения дефицита бюджетов разных уровней, обеспечивающих стабильность и устойчивое развитие экономики государства.

The most important aspects of state property management are considered. The legal and organizational problems associated with the management of state property are analyzed, including the establishment and transfer of ownership, regulation and control over the use of property, as well as the legal protection of state assets. The importance of competent and effective management of state-owned property is assessed. Eliminating gaps in legislation, as well as the search for new approaches to the issue of state property management are considered as one of the tools for filling the budget deficit at various levels, ensuring stability and sustainable development of the state’s economy.
СОСТОЯНИЕ И ПРОБЛЕМЫ РАЗВИТИЯ ОТРАСЛЕВОЙ ЭКОНОМИКИ РЕГИОНА В СОВРЕМЕННЫХ УСЛОВИЯХ
Authors: Гасанов Магомед Алиевич , Омаров Аюб Закариевич
Published: December 2024

В статье рассматриваются состояние и актуальные проблемы системного развития отраслевой экономики региона в современных условиях. Выявлены особенности функционирования отрасли с позиции инновационных преобразований. При этом отмечается, что его объекты обслуживают не только сферы материального производства, но и объекты непроизводственной сферы и населения. Предложено прогнозирование отраслевой экономики и управление ею осуществляться органической взаимосвязи всех его частей технологического процесса создания продукта регионального производства. Основой исследования являются научные труды российских и зарубежных ученых в области экономики производственно-отраслевой инфраструктуры. В ходе исследования использованы методы научного познания: системный анализ, сравнение и экономико-организационные методы управления.

The article considers the state and current problems of systemic development of the sectoral economy of the region in modern conditions. Peculiarities of the industry functioning from the point of view of innovative changes have been revealed. At the same time, it is noted that its objects serve not only the spheres of material production, but also the objects of the non-production sphere and the population. It is proposed to predict the industry economy and manage it by organic interconnection of all its parts of the technological process of creating a product of regional production. The research is based on scientific works of Russian and foreign scientists in the field of production and industry infrastructure economics. The study used methods of scientific knowledge: system analysis, comparison and economic and organizational management methods.
Transforming carbon dioxide into high-value chemicals via sustainable solid oxide electrochemical reactor
Authors: Shi Nai , Hu Xueyu , Xie Yun , Zhang Shaowei , Hyodo Junji , Zhu Kang , Shao Zongping , Yamazaki Yoshihiro
Published: December 2024

Achieving a carbon-neutral society requires strategies that seamlessly integrate environmental sustainability with economic viability. Solid oxide electrochemical reactors (SOERs) hold the potential to concurrently recycle CO2 while synthesizing high-value propylene from low-cost gases using surplus renewable electricity. However, existing SOER designs face significant challenges in slow reaction kinetics and instability. We present evidence that Fe-Ni-Ru alloy@FeOx core-shell nanoparticles on the Sr2Fe1.5Mo0.4Ni0.05Ru0.05O6-δ electrode of SOER substantially enhance electrochemical CO2 reduction at the cathode, and propane conversion to propylene and ethylene at the anode through the promotion of active oxygen species at the surfaces. The formation of core-shell nanoparticles lowers the activation energy of polarization resistance from 2.1 eV to 0.82 eV, facilitating high current densities and 150 h of stable SOER operation with an 80% selectivity for propylene and ethylene production. Density functional theory calculations suggest that this enhancement is due to the reduced activation energy for dissociative CO2 reduction on the surface of Fe-Ni-Ru alloy@FeOx core-shell nanoparticles. These results show the potential of the self-organized core-shell nanoparticles in SOERs for economical CO2 recycling, offering a promising approach in the pursuit of a carbon-neutral future.
Separation of Tetrahydrocannabinol Fraction from Cannabis indica Extracts by Chromatographic Method
Authors: Khan Ubaid Ullah , Munir Shafqat , Khan Shamsher , noorani sha Nishat
Published: December 2024

Tetrahydrocannabinol (∆9-THC) from Cannabis indica leaves was extracted by using solvent extraction method applying condenser apparatus. The molecular and physical attributes of ∆9-THC, or tetrahydrocannabinol, were identified. The collected oil’s content and a number of additional variables were studied. The optimum oil yield was predicted. Two samples were produced with multiple parameters. Sample (B) was made by soaking the leaves for seven days, whilst sample; (A) was made by using a condenser the instrument. The derived oil’s content and multiple kinds of other factors were studied. For characterization of both samples TLC, GC-MS, IR and HPLC techniques were applied. Various physical and chemical characteristics for Tetrahydrocannabinol (∆9- THC) oil was analyzed as different values such as acid value, specific gravity, saponification value, refractive Index by titration. Some physical tests were also performed for the detection of proteins, carbohydrates, Steroids, tennins, gums and mucilage. Both samples’ results proved wide differences. Due to elevate oxidative stability and psychoactive nature Tetrahydrocannabinol (∆9-THC) oil has many medicinal applications.
How to Correct Erroneous Symmetry-Breaking in Coarse-Grained Constant-pH Simulations
Authors: Beyer David , Blanco Pablo M. , Landsgesell Jonas , Kosovan Peter , Holm Christian
Published: December 2024

The constant-pH Monte Carlo method is a popular algorithm to study acid-base equilibria in coarse-grained simulations of charge regulating soft matter systems including weak polyelectrolytes and proteins. However, the method suffers from systematic errors in simulations with explicit ions, which lead to a symmetry-breaking between chemically equivalent implementations of the acid-base equilibrium. Here, we show that this artifact of the algorithm can be corrected a-posteriori by simply shifting the pH-scale. We present two analytical methods as well as a numerical method using Widom insertion to obtain the correction. By numerically investigating various sample systems, we assess the range of validity of the analytical approaches and show that the Widom approach always leads to consistent results, even when the analytical approaches fail. Overall, we provide practical guidelines on how to use constant-pH simulations to avoid systematic errors, including cases where special care is required, such as polyampholytes and proteins.
Nature of the oxygen loss induced rocksalt layer and its impact on capacity fade in Ni-rich layered oxide cathodes
Authors: Shah Nickil , Paez Fajardo Galo , Banerjee Hrishit , Pandey Gaurav , Menon Ashok , Ans Muhammad , Majherova Veronika , Bree Gerard , Bolloju Satish , Grinter David , Ferrer Pilar , Thakur Pardeep , Lee Tien-Lin , Loveridge Melanie , Morris Andrew , Grey Clare , Piper Louis
Published: December 2024

In Ni-rich layered oxide cathodes, cycling above the oxygen-loss threshold voltage (~4.3 V vs. Li+/Li) promotes structural transformations at the cathode surface. These transformations can result in various thermodynamically favorable rock-salt like (RSL) structures (NiO, NiOx, and/or LiyNizO) that have different Li+ transport properties. Elucidating the precise phase type in the RSL can help determine design strategies to improve Li+ kinetics and identify design rules to suppress capacity fade in Ni-rich cathodes. This study utilizes surface-sensitive X-ray absorption spectroscopy in combination with first principles simulations and distinguishes the layered oxide spectroscopic features from surface reduced layers of pure NiO and LixNi1-xO. The transport of lithium ions through this oxygen-loss-induced surface reconstructed layer is studied with operando X-ray diffraction in a pouch cell as a function of cycling aging and constant voltage protocols.
Джерела фінансування повоєнного відновлення системи охорони здоров’я (ключові інструменти)
Authors: Юнгер Віталій Іванович
Published: December 2024

Визначено, що державно-приватне партнерство може бути використане як інструмент залучення фінансових ресурсів приватних організацій для відновлення інфраструктури системи охорони здоров’я та окремих закладів охорони здоров’я; реалізації інноваційних проєктів щодо лікування, дослідження та моніторингу стану охорони здоров’я, фармацевтичних досліджень; підвищення рівня кадрового потенціалу та сукупності інших напрямів. Ідентифіковано напрями застосування інструменту державно-приватного партнерства для повоєнного відновлення системи охорони здоров’я з огляду на: виокремлення учасників державно-приватного партнерства; пріоритетні форми держано-приватного партнерства у відновленні системи охорони здоров’я; пріоритетні форми реалізації проєктів державно-приватно партнерства щодо повоєнного відновлення системи охорони здоров’я; державне стимулювання бізнесу до участі в державно-приватному партнерстві щодо відновлення системи охорони здоров’я та ефект від його впровадження. Виявлено ключові напрями спільної діяльності, серед яких: розробка нових методів лікування в різних напрямах медичної допомоги; розробка нових підходів до тактичної медицини в умовах надзвичайних ситуацій; розробка нових ліків; інші види інноваційних продуктів у сфері медицини. Виокремлено напрями розширення діяльності та автономії закладів охорони здоров’я державної (комунальної) форми власності в розрізі операційної діяльності (медична, освітньо-просвітницька, науково-дослідна) та фінансоіої діяльності (відкриття депозитів у національній та іноземній валютах; отримання позик в банках та фінансових установах). Визначено необхідність реформування діяльності закладів охорони здоров’я в контексті організаційно-правової форми для реалізації їх автономії. Розширення операційної діяльності дозволить отримати додаткові доходи для забезпечення фінансової стабільності закладу охорони здоров’я.
State of the Art in Language Testing: Ten Years of History or How to Deal with Assessment
Authors: Herrera Soler Honesto
Published: December 2024

A follow-up of the ten-year Language Testing (LT) history is canied out in this study. Our aim is to give a broad idea of what has been done in this Journal and whether or not it has been the forum for the assessment of language ability it intended to be over this period. Firstly we take the 1984 issues as a key moment in the ten-year history of LT, since they provide the route map to be followed and developed in subsequent issues. Then, attention is paid to the articles on Item Response Theory (IRT), a thread that runs through this whole journal, and to the research on TOEFL, which is seen as a second thread running through the texture of LT. Finally, contributions on authenticity, self-assessment, extralinguistic factors and testing techniques are considered. On the whole, it can be concluded that the range of topics discussed over these ten years make up the real state of the art in language testing.
The Role of VN In Functional Syntax: Some OE Patterns
Authors: Martín Arista Javier
Published: December 2024

In this paper we restrict, in favour of X constituents, the role played by VN in a functional syntax. More specifically, we suggest that the element central to the formulation of synchronic and diachronic expression rules is the focusbearing constituent, that is, X-not VN-in languages that show full or partial OV morphosyntax. We comment on the inadequacy of the V2 Rule and formulate a hypothetical description and explanation of Old English passive constructions: we shall speak of "unmarked topic" whenever this pragmatic function is assigned to a constituent that does not occupy clauseinitial position and of unmaJked focus whenever this function is assigned to the constituent that lies in inter-verbal position, clause-initial, second and final position. This explanation is consistent with the pragmatic mode advanced by Bossuyt (1985: 15ft) and Tejada (1988: 83ff) and with the explanations for OE constituent order put forward by Dik (1980: 153) and Bossuyt (1985: 27). We find points of convergence with Bean (1983: 136) as well. We also put forward the hypothesis that a markedness hierarchy as regards pragmatic function assignment may be proposed, whose validity we try to demonstrate.
Narration-Parody-Intertextuality: Rewriting the Past in Charles Palliser's The Quincunx
Authors: Martínez Alfaro María Jesús
Published: December 2024

The aim of this paper is to analyse Charles Palliser' s first novel -The Quincunx (1989)- in the light of the central role played by intertextuality in postmodernist literature in general and in contemporary British metafiction, in particular. The Quincunx has all the ingredients of the traditional realist novel. However, despite all the echoes and reverberations from a wide range of nineteenth-century works with which the reader is free to trace relations, The Quincunx does not constitute an innocent imitation but, rather, a parodic rewriting of its Victorian (mainly Dickensian) intertexts. One particular aspect of the novel-the use and patterning of nmrntive voices-has been analysed in detail as a means to illusu·ating the way in which parody can be turned into a wonderful vehicle to express the concerns of the present through the literature of the past.
The "Memo" Pages of Franklin's Autobiography: On the History of American and English Life Writing
Authors: Rodríguez García José María
Published: December 2024

In 1783 Abel James and Benjamin Vaughan sent each a letter to Franklin asking him to resume the writing of his life, which he had begun in 1771. In addition to providing Franklin with a legitimate occasion lo continue his truncated self-narration (he is asked to teach other Americans how to live their lives) the two letters consider life writing as a disciplinary technology and a nation-building institution. They also comment upon the competition among rival modes of self-making and self-representation taking place at the time on both sides of the Atlantic, as evinced in the writings of Edwmds, Jefferson, Fielding, and Boswell, among others.
View (1940-47), the Avant-garde, and the Uncertain Life of Objects: Criticism as if Fragments Mattered
Authors: Suárez Juan A.
Published: December 2024

This article seeks to study avant-garde cultural production as a fragmentary discourse invested in exploiting the potential incongruity of objects disconnected from overarching narratives. As guiding critical models to this end, it assesses Walter Bejamin's use of montage and Roland Bruthes's notion of the punctum; the object chosen for testing this approach is the discourse of the U.S. surrealist magazine View (1940-1947). Ultimately, the essay proposes an approach to the avant-garde that would incorporate avant-garde strategies into the rhetoric of criticism.
Theme-Antics and the The-Eerie Class: CrWit(t)icism in wRap
Authors: David Walton
Published: December 2024

Rather than an abstract, I shall offer an abstruct or obstract: something which could be said to stand in the way rather than lighten it. Yet, I would have it retain something of the abstract—an incorporeal substance (a hal[l]o) floating above what lies below. What is it that lies below? Any attempt to describe what happens there in a language which gestures towards an unambiguous style, clarity of argument, neat concision etc. would militate against my tendency to de-scribe. I would say that this is not so much an article but an "art-tickle." Here, then, a ludic cycle, pedagogical joy-ride into the uncommon, unorthodox terror-tory of liteRAREry theory, via vary-us forms of song (rap, punk, blues): an attempt to Sir-jest (with a modicrumb of wit) an alter-native means of intro-juicing concepts. But at a cost. This is to be done in a lang-wage (O mischievous sprite!) that imp-lies, through its very shApe, the condition of the linguistic sign (post Derrida, Lacan, Kristeva & C”), witch may be useful in itself, as a kind of exemplum to the way theory may be presented or written about. So, I offer a few comments on motorvation. And to finish, there are "A Few RidDling Quest-ions for the feary glass" and a "Vermiform Appendix" of other possibilities.
Endophoric Signposting: A Contrastive Study of Textual References in L2 Czech Master's Theses and Native English Academic Writing
Authors: Marie Lahodová Vališová
Published: December 2024

The aim of this study is to contribute to cross-cultural and cross-disciplinary discourse analysis, shedding light on English L2 learners’ metadiscursive practices. Focusing on a specialised learner corpus of English-medium Master’s theses written by Czech university students, the research explores the occurrence of endophoric markers and their characteristics. To enable cross-linguistic and cross-cultural comparison, a reference corpus of representative L1 English academic discourse was compiled. A new taxonomy used here, which draws on Hyland’s list of endophoric markers (2005) and an extensive literature review, categorises endophoric markers into three groups: purely directional, markers using specific words, and a category combining the first two. The study investigates the occurrence and function of these markers, focusing on anaphoric, cataphoric, and non-directional references. It also aims to identify differences in the usage of endophoric markers in English between L2 novice writers and experienced L1 academic writers, providing insights into trends and patterns in the employment of endophoric markers in academic writing in a way that accounts for disciplinary and linguistic factors. The results reveal higher endophoric marker frequencies in the Master’s Thesis Corpus, suggesting distinctive discourse patterns among Czech learners using English as an L2, with a predominance of specific endophoric markers and notable cross-disciplinary variation.
Why Do Learners with Limited Resources Use or Not Use Technology in Mathematics Learning?
Authors: Moila Mathomo Meriam
Published: December 2024

Current statistics show that the number of grades 10 – 12 mathematics learners in South African schools is still very low compared to learners in general curriculum subjects. Furthermore, these learners do not perform well on the grade 12 mathematics tests. Technologies are seen as tools that attract learners to mathematics and positively influence mathematics teaching and learning. This mixed methods study was conducted against this background, in consideration of the need for ongoing research on learners’ use or non-use of educational technology in mathematics in socio-economically disadvantaged South African schools. This study investigated two socio-economically disadvantaged schools in South Africa and, included 79 learners between grades 10-12 who filled out a questionnaire. Two focus group interviews were also conducted. Key findings are that the learners’ use of educational technology in the two schools is consistent with the teachers’ use of such technology. The most used technologies are the calculators and the smartphones. In conclusion, I argue that teachers’ appropriate use of calculators and smartphones in teaching mathematics positively influences learners’ use of calculators and smartphones. It is, therefore, recommended that the use of calculators and smartphones in mathematics teaching be encouraged in the context of socio-economically disadvantaged schools.
A Systematic Review on the Improving Strategies and Influencing Factors of Vocational Students’ Learning Engagement in Blended Teaching Environment
Authors: Chen Zidi , Jalaludin Nur Atiqah , Rasul Mohamad Sattar
Published: December 2024

Blended teaching (BT), which combines traditional face-to-face instruction with online components, has become an inevitable trend in vocational education, especially for its potential to offer flexibility, simulation of real working scenarios and hands-on training. Students’ learning engagement is regarded as a critical factor for BT's success. Despite progress, theoretical gaps remain, particularly in the influencing mechanisms and strategies for enhancing vocational students’ learning engagement in BT contexts. This systematic review aims to fill this gap and provide implications for future BT practices. Sourced from three databases (Web of Science, SCOPUS, and CNKI) and complying with the PRISMA checklist, 38 studies regarding vocational students’ learning engagement in BT contexts from 2014 to 2024 were reviewed looking at research features, BT techniques, influencing factors and improving strategies. Findings showed that technological applications and learning management systems (LMS), gamification, flipped classrooms and MOOCs are predominant approaches in BT. In addition, it is a well-designed teaching strategy and cohesive learning community that enhances students’ learning engagement. Besides, individual factors such as curiosity, academic self-efficacy, and career expectations also affect students’ learning engagement. This study also provides evidence-based strategies for enhancing vocational students’ learning engagement for researchers and practitioners.
An Experimental Study on the Impact of Collaborative and Active Learning on Vocational Students' Learning Achievement and Self-Motivation
Authors: Li Ruijuan , Srikhao Sarit , Jantharajit Nirat
Published: December 2024

The study examines a blended instructional approach combining collaborative and active learning to improve vocational students' learning achievement and self-motivation. An experimental design was utilized, dividing vocational students into control and experiment groups. The experiment group participated in a one-month collaborative and active learning intervention, while the control group received traditional instruction. The experiment group achieved significant gains in academic achievement, with pre-test and post-test means rising from 79.63 to 86.15 (t=19.72, p<0.05) and self-motivation scores increasing from 37.82 to 42.74 (t=19.71, p<0.05). In contrast, the control group exhibited lower post-test scores in both academic achievement (mean=80.16, t=3.67, p<0.05) and self-motivation (mean=38.4, t=5.31, p<0.05). These results indicate that integrating collaborative and active learning strategies significantly impacts learning achievement and self-motivation in vocational education. This suggests that this instructional approach is highly effective in improving student outcomes.
Rol de enfermería en la atención de emergencia hipertensivas
Authors: Pacheco Cabrera Carmen Alejandrina , Chumacero Pacheco Martha Alejandra , Gaviria Vasquez Aura Gisela
Published: December 2024

Las emergencias hipertensivas son una condición médica crítica caracterizada por un aumento agudo y significativo de la presión arterial, acompañado de signos de daño a órganos diana como el corazón, los riñones, el cerebro y los pulmones. Las causas más comunes incluyen la falta de cumplimiento con los medicamentos antihipertensivos y el uso de simpaticomiméticos. La evaluación del paciente es esencial para identificar los síntomas y signos presentes, como dolor de cabeza, mareos, alteración del estado mental, dificultad para respirar, dolor en el pecho, disminución de la producción de orina, vómitos o cambios en la visión. El tratamiento principal es la reducción rápida de la presión arterial utilizando medicamentos intravenosos de acción rápida y fácilmente titulables, como labetalol, esmolol, nicardipina y nitroglicerina. El manejo de enfermería incluye monitorear la presión arterial, administrar medicamentos según lo prescrito y educar al paciente sobre la importancia de tomar sus medicamentos y mantener un estilo de vida saludable.
Nueva guía para el manejo de la hipertensión arterial, incluyendo la importancia de la medición y tratamiento personalizado
Authors: Villacres Fernández Francisco Alejandro , Cruz Villegas Janeth Aurora , Ayala Esparza Verónica Alexandra , Hurtado Astudillo Janeth Reina
Published: December 2024

El objetivo del estudio plasmar una nueva guía para el manejo de la Hipertensión arterial, incluyendo la importancia de la medición y tratamiento personalizado, debido a que año a año aumentan las cifras relacionadas con esta enfermedad a nivel mundial, viendo afectado una parte de la población, preciso que la misma al no ser tratada de forma adecuada puede llegar a generar riesgos de ataque cardiacos, ataques cerebro vasculares e incluso fallas en la salud renal del paciente que la padece esta enfermedad, por lo que es importante mantener controles rigurosos a fin de evitar que se genere una muerte prematura de quienes la padecen. En cuanto a la estructura metodológica del presente artículo científico se consideró, el uso del paradigma de la post modernidad, donde se utilizó un tipo de investigación documental, empleando como técnicas el análisis de contenido que permitió el desarrollo de este cuerpo de investigación a través de la revisión documentos especializados para el abordaje exhaustivo del presente estudio. En cuanto al procesamiento de la información, se empleó el análisis del contenido para la selección de contenido teórico que contribuyera a la construcción y exposición del presente cuerpo de investigación. Finalmente, se pudo concluir que, es necesario mantener un control para la detección temprana de la hipertensión arterial que un factor clave es la detección temprana y segundo mantener hábitos que sean saludables a fin no llegar a generar problemas que comprometan la salud e incluso la vida del paciente.
Avances en trasplante facial y reconstrucción compleja
Authors: Cabascango Soria Adriana Cristina , Saraguro Martínez Mariuxi Cecibel , Villarreal Armas Mady Sariah , Remache Velastegui Jhonatan Fabricio
Published: December 2024

El campo de la cirugía reconstructiva ha experimentado una revolución en las últimas décadas, gracias a los avances en trasplante facial y reconstrucción compleja. Estas técnicas han permitido a pacientes con deformidades faciales severas recuperar no solo su apariencia física, sino también su función y, por ende, su calidad de vida. La metodología empleada para esta revisión bibliográfica consistió en una exhaustiva búsqueda en bases de datos científicas como PubMed, Scopus y Web of Science, utilizando combinaciones de palabras clave como "trasplante facial", "reconstrucción facial", "cirugía plástica", "avances", "técnicas quirúrgicas". Se incluyeron artículos publicados en los últimos 20 años, con énfasis en estudios originales, revisiones sistemáticas y metaanálisis. Los avances en trasplante facial y reconstrucción compleja representan un hito en la medicina moderna. Si bien aún existen desafíos por superar, las perspectivas futuras son prometedoras y abren nuevas posibilidades para mejorar la calidad de vida de los pacientes con deformidades faciales severas. La investigación continua y la colaboración multidisciplinaria serán fundamentales para seguir avanzando en este campo y garantizar que estos procedimientos sean accesibles y beneficiosos para todos aquellos que los necesiten.
Técnicas y materiales para la restauración dental: una revisión sistemática
Authors: Sánchez Sánchez Raciel Jorge , Paredes Baidal María Fernanda , Angulo Quiñónez Leonardo Fabricio , Sánchez Valdiviezo Martha Narcisa
Published: December 2024

El objetivo general de este artículo científico fue identificar y analizar las técnicas y materiales más utilizados en la restauración dental mediante una revisión sistemática de la literatura científica reciente. Se realizó una búsqueda exhaustiva en bases de datos como PubMed, MDPI y Web of Science, utilizando términos de la lista MeSH relacionados con "Restauración dental", "Materiales dentales" y "Técnicas de restauración". Se incluyeron estudios publicados entre 2018 y 2024, seleccionados según criterios de elegibilidad predefinidos (artículos en inglés, portugués y español, estudios clínicos y revisiones relevantes). De un total inicial de 500 artículos, 21 fueron incluidos tras el proceso de cribado y evaluación de calidad. Los materiales más destacados fueron las resinas compuestas de última generación, cerámicas reforzadas y biomateriales híbridos, seleccionados por su durabilidad y estética. Entre las técnicas predominantes se identificaron el uso de sistemas adhesivos universales, procedimientos CAD/CAM y métodos de fotopolimerización optimizados. También se destacó el impacto de los avances en nanotecnología y bioingeniería en la restauración dental. La restauración dental ha evolucionado significativamente gracias a innovaciones en materiales y técnicas, mejorando la funcionalidad y estética de los tratamientos. Sin embargo, se requiere más investigación para evaluar la longevidad de las nuevas tecnologías y su impacto a largo plazo en diferentes grupos poblacionales.
A Critique of Contemporary Economic Justice and Sharia Economic Law on The Tompangan Tradition
Authors: Suaidi Suaidi , Sodiqin Ali , Rozaki Abdur
Published: December 2024

The tradition of tompangan, which was originally a form of social solidarity between residents, has shifted into an informal debt system, with returns exceeding the initial amount given, thus causing injustice and economic inequality. This study discusses the critique of contemporary economic justice and the relevance of Sharia Economic Law to the shift in the tradition of Topangan in Madura. This study uses a qualitative approach with data obtained through interviews and observations. The results of the study indicate that social change and modernization have shifted the traditional value of tompangan, which was originally a grant, into a qardh (debt) contract that tends to be capitalistic. Based on the perspective of Sharia economic law, returns that exceed the amount of the loan can be categorized as usury which is prohibited in Islamic law. This study also found that the community still considers this practice socially legitimate despite the uncertainty and injustice in the return of tompangan goods. Therefore, combining insights from the tompangan tradition with contemporary economic justice theory can open up new perspectives for economic policies that are fairer and more responsive to the needs of local communities and in line with the principles of Sharia economic law.
Pain in Sickle Cell Disease and Acute Varicella Zoster Pain
Authors: Santos Garcia João Batista , Schwartzmann Bruno Ana Laura
Published: December 2024

This tutorial addresses the etiology and management of pain associated with sickle cell disease and acute pain related to varicella zoster. Both are severe pain conditions with a significant impact on individuals' functionality and the potential to cause substantial suffering.
Semi-Automatic Generation of Preoperative Surgical Plans for Complex Femoral Deformity Correction
Authors: Dikland Felix , Gerbers Jasper , Kaptein Bart
Published: December 2024

Complex bone deformation of the femur can occur in bone disease. This can cause significant functional impairment and is often an indication for surgery. Current technology enables preoperative planning and execution of these complex multi-planar osteotomies with high accuracy. A novel solution is presented that generates preoperative plans using Blender. The model automatically optimizes femoral shaft shape within the boundaries of clinical constraints. 20 cases of femoral deformity were processed by the model retrospectively. Eighteen of twenty preoperative plans were accepted by two independent clinical experts. This shows the ability of the model to generate preoperative plans of sufficient clinical quality. Four random cases were compared to manual preoperative planning. These showed comparable results. The collum anteversion angle was normalized in four cases in the automatic group and only in one for the manual group. The manual planning process was slower in every case, ranging from 31% to 575% slower. The proposed method, allows fast interactive surgical planning within a constraint based design and is a promising aide for complex femoral correction planning.
Automatic Assessment of AI-produced 3D Medical Image Segmentations of the Scapula using Deep Learning
Authors: Thoviste Garance , Mabrouk Lhoussein Axel , Bertrand Fabrice , Daviller Clément
Published: December 2024

Artificial intelligence (AI) and machine learning (ML) take an ever-growing place in medical care. Anatomical segmentation and reconstruction is one of the fields where ML reveals to be very efficient. Yet, verification of ML results still requires human verification and correction especially on pathologic morphologies. We propose an automatic assessment of AI-generated scapular reconstructions. Based on deep learning (DL), it separates predictions requiring little to no revision from predictions where corrected voxels represent more than 1% of the scapula, with an accuracy of 80%.
Estimation of Musculoskeletal Features by Infering Femur from Thigh Skin
Authors: Gueye Oulimata , Dardenne Guillaume , Troccaz Jocelyne , Burdin Valerie
Published: December 2024

Musculoskeletal disorders (MSDs) pose significant healthcare challenges. This study ad- dresses diagnostic limitations by proposing a novel algorithm able to estimate key anatom- ical features of the femur from thigh skin. Leveraging a dataset of 50 angioscanner thigh- femur pairs, we pioneer a robust Statistical Shape Model (SSM) that captures correlations between the skin and the underlying femur. Femur inference from a known thigh uses a Bayesian approach and demonstrates promising results. Although the femur reconstruc- tion error may seem high, it is important to note that the goal is MSK feature estimation rather than precise bone reconstruction. Preliminary results are promising, suggesting a potential application in non-invasive MSK diagnosis for surgery.
An Interactive Osteotomy Platform for Automated Planning of 3D Multiplanar Leg Malalignment-Correcting Osteotomies
Authors: Veerman Quinten , Tuijthof Gabriëlle , Olde Heuvel Judith , Hoogeslag Roy
Published: December 2024

Introduction 3D imaging technologies allow for more accurate planning of multiplanar corrective osteotomies around the knee. However, 3D planning introduces complexity. For example, varus/valgus is expressed in the coronal plane of the leg, while posterior tibial slope is expressed in the sagittal plane of the tibia. We present a software platform that deals with this complexity.

Methodology A high tibial osteotomy was parametrized using 5 parameters: hinge axis rotation in axial plane; hinge axis tilt in axial plane; hinge axis position along longitudinal axis; hinge axis distance to cortex; osteotomy opening angle. A MATLAB-algorithm was developed in which the effect of each possible combination of osteotomy parameters was obtained on change in alignment parameters expressed in coordinate systems of the tibia and leg. By finding the set of osteotomy parameters that approaches the predefined change in alignment parameters the closest, a 3D osteotomy planning can be linked to a desired outcome.

Results A digital interactive osteotomy planning platform was developed that automatically computes the required hinge axis orientation and osteotomy opening/closing angle for a given predefined outcome of change in posterior tibial slope and %-weight-bearing-line in the coordinate systems of the tibia and leg, respectively, with an error of <0.1°. During planning, the user is able to manually tweak the osteotomy and is given real-time feedback on the resulting trade-offs.

Conclusion The presented osteotomy planning platform allows for automatic and complex 3D planning of multiplanar leg malalignment correction, while integrating that alignment parameters are measured in different coordinate systems.