bluuebunny/crossref_metadata_2025 huggingface dataset:
Drake chemical workers' health registry study: I. Notification and medical surveillance of a group of workers at high risk of developing bladder cancer
Authors: Marsh Gary M. , Leviton Laura C. , Talbott Evelyn O. , Callahan Catherine , Pavlock David , Hemstreet George , Logue James N. , Fox James , Schulte Paul
Published: April 2007

A medical surveillance program and epidemiologic study of 408 former workers of the Drake Chemical Company (now a Superfund waste site) was established in 1986. The Drake Health Registry Study was initiated because these workers had probable past exposures to beta‐naphthylamine (BNA), a potent bladder carcinogen. The registry is widely viewed as a model for notification of workers at high risk of disease due to past occupational exposures. By the 40th month, 90% of the 366 living workers had been notified of the existence of the registry; 262 had been enrolled in the annual or semiannual screening for bladder cancer. Among these, 27 persons have had abnormal screening results indicating moderate to high risk of bladder cancer and have been made eligible for further diagnostic tests. While no invasive bladder tumors were found among 18 persons completing the extended diagnostic evaluation, two diagnoses of moderate to severe dysplasia have been made. The registry has also identified three living and three deceased cases of bladder cancer in the cohort; a mortality analysis showed a 20‐ to 30‐fold excess of bladder cancer. An incidence projection, based on the six identified cases, reveals that between six and ten new bladder cancer cases are likely to occur among the Drake cohort over the next 20 year period.
Workers' compensation cost shifting: An empirical study
Authors: Zwerling Craig , Ryan James , Orav E. John
Published: April 2007

It has been suggested that health maintenance organizations (HMOs) overdiagnose work‐related injuries and illnesses to increase their income. This study compared the Workers' Compensation experience of 2,176 Boston postal employees enrolled in a large HMO with that of 3,473 employees enrolled in a large fee‐for‐service health insurance plan. It controlled for the potential confounders of age, gender, job classification, type of injury, and duration of employment. It found no difference in the incidence of injuries: 5.93% for HMO enrollees and 6.25% for fee‐for‐service plan enrollees. Medical costs averaged $475 for HMO enrollees and $838 for fee‐for‐service plan enrollees (p = 0.018). Total costs averaged $909 for HMO enrollees and $1388 for fee‐for‐service plan enrollees (p = 0.063). In our cohort, there was no evidence of cost shifting. It appeared that the HMO provided less expensive medical care for injured postal workers.
Is brain cancer mortality increasing in industrial countries?
Authors: Davis Devra Lee , Ahlbom Anders , Hoel David , Percy Constance
Published: April 2007

This paper analyzes age‐specific trends in brain and other central nervous system cancer mortality from 1968 to 1987 in several major industrial countries. It also examines changes in the use of diagnostic confirmation technology and trends in incidence in the U.S. National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) program from 1973 to 1987 to estimate the influence of diagnostic factors on recent mortality trends. Other sources of error have not been evaluated in this paper. Agespecific analyses of brain and other nervous system cancer mortality show drastic increases in persons ages 75‐84 and consistent increases in younger age groups in most countries, although mortality declined in the U.S. in persons 0‐24 by 2% annually. In the SEER program, brain cancer incidence increased significantly by 2%, 1%, and 5% annually in persons aged 0‐44, 65‐74, and 75‐84, respectively. Throughout this time period, microscopic or radiographic confirmation occurred in at least 96% of all incident cases of brain and other central nervous system cancers diagnosed before death, with older persons receiving consistently more radiographic tests than younger persons. Changes in diagnoses across populations and over time are unlikely to account completely for these increasing trends which are occurring simultaneously in both males and females in major industrial countries. Additional studies need to be conducted, to exclude artifacts, to assist health care planners in anticipating treatment demands, and to detect preventable causes of these changing trends.
Reproductive hazards of fire fighting I. Non‐chemical hazards
Authors: Agnew Jacqueline , McDiarmid Melissa A. , Lees Peter S. J. , Duffy Richard
Published: April 2007

Fire fighters are regularly exposed to chemical and non‐chemical agents that have known or suspected adverse effects on reproductive health. Although chemical agents have received some attention, non‐chemical hazards such as heat, noise, and physical exertion have only recently been examined for their reproductive effects. There is evidence that heat, noise, and physical exertion may affect various endpoints of reproductive health, including fertility, fetal loss, and growth parameters of the offspring. In particular, hyperthermia, a major fire fighting hazard, has been shown to impair male fertility and may also be teratogenic. Further study of the potential reproductive effects of this and other common non‐chemical agents in the fire environment is needed to ensure the reproductive health of male and female fire fighters.
Acrylamide neuropathy in a South African factory: An epidemiologic investigation
Authors: Myers Jonathan E. , Macun Ian
Published: April 2007

Aerylamide monomer concentrations and peripheral neurotoxicity were investigated in workers at a factory producing polymer. Monomer levels ranged from 0.07 to 2.5 times the recommended exposure limit of the U.S. National Institute for Occupational Safety and Health (1988). Those workers with exposure exceeding the limit had increased prevalences of acrylamide‐related abnormalities. Logistic regression showed dose‐response relationships with exposure for symptoms, abnormal sensation, decreased motor strength, abnormal gait or rombergism, and skin abnormalities. The overall prevalence of acrylamide‐related abnormality was 32% in the total work force and 67% among those exceeding the limit compared with 14% in those exposed below the limit. Environmental exposure determinations and conventional clinical approaches are relatively insensitive measures. Associations might have been stronger if a biological exposure measure had existed and if quantitative neurornetric techniques had been applied. Electrophysiological methods are not readily available in many settings; the use of the Vibratron II for quantitative field testing holds promise.
Effects of elemental mercury exposure at a thermometer plant
Authors: Ehrenberg Richard L. , Vogt Richard L. , Smith Alexander Blair , Brondum Jack , Brightwell W. Stephen , Hudson Paul J. , McManus Kevin P. , Hannon W. Harry , Phipps Frederick C.
Published: April 2007

This study compares 84 mercury‐exposed workers at a thermometer manufacturing facility with 79 unexposed workers for evidence of chronic mercury toxicity. Personal breathing‐zone air concentrations of mercury ranged from 25.6 to 270.6 μg/m3 for thermometer workers. Urinary mercury levels in the study population ranged from 1.3 to 344.5 μg/g creatinine, with eight (10%) participants exceeding 150 μg/g creatinine and three workers exceeding 300 μg/g creatinine, which indicates increased absorption of mercury among the thermometer workers. All urine mercury levels in the comparison group were compatible with normal background levels in unexposed adults (<10 μg/g creatinine). Thermometer plant workers reported more symptoms than did controls; in general, these differences were not statistically significant and could not be specifically associated with mercury exposure. Static tremor, abnormal Romberg test, dysdiadochokinesia, and difficulty with heel‐to‐toe gait were more prevalent among thermometer workers than control workers, which could not be associated with recent mercury exposure; there was some suggestion of an association with chronic exposure. There were no intergroup differences for the standard clinical tests of renal function except for a significantly higher mean specific gravity among the thermometer workers. A positive correlation was found, however, between urinary N‐acetyl‐b‐D‐glucosaminidase (NAG) and urinary mercury. There was no consistent evidence for intergroup differences in proximal renal tubule function, as measured by urinary β2‐microglobulin (B2M) or retinol binding protein (RBP).
Validity of occupational histories obtained by interview with female workers
Authors: Brisson Chantal , Vézina Michel , Bernard Paul Marie , Gingras Suzanne
Published: April 2007

This study measured the validity of work histories obtained by interview with 84 female workers and examined specific factors which influence such validity. This is the first validation of work histories collected by interviews with women. The validity of each interview was assessed over a period of 29 years, from 1955 to 1983. The information provided by the worker was compared annually to job information registered in public and union records. On the average, interviews yielded the correct information (either employer's name or nonworking year) for 81% of the person years of these subjects. However, there was a time effect; the average validity score for recent employment (1972‐1983) was 89%, while that for employment in the more distant past (1955‐1971) was 74%. Furthermore, workers who had fewer jobs, had longer durations of employment, and were non‐French speaking had higher validity scores. Most of these findings are consistent with previous studies conducted among male respondents.
Risk and severity of non‐back occupational injuries after lumbar laminectomy for degenerative disc disease
Authors: Zwerling Craig , Ryan James
Published: April 2007

An increased risk, after lumbar laminectomy, for lost work time occupational back injury (odds ratio, 5.9; 95% confidence interval, 1.9‐18.8) and disability (mean 292.8 days vs. 24.8 for controls) was previously demonstrated. Such differences could be due to physical sequelae of back surgery or to psychosocial factors. Extensive literature addresses the impact of psychosocial factors on the incidence of occupational injury and severity of disability. This study assumes that psychosocial factors would affect both back and non‐back injuries, while surgery‐related physical factors would not. The odds ratio for non‐back lost work time injury for subjects in the same cohort studied previously was 1.5 (0.5‐4.5), with no significant increase in duration of disability (mean 27.0 days vs. 24.8 for controls). The increased risk for back injury in the absence of an increased risk for other injuries suggests that physiologic rather than psychosocial factors provide the more likely explanation for the differences in back injuries.
The usefulness of bronchoalveolar lavage in identifying past occupational exposure to asbestos: A light and electron microscopy study
Authors: Dodson Ronald F. , Garcia Joe G. N. , O'sullivan Michael , Corn Carolyn , Levin Jeffrey L. , Griffith David E. , Kronenberg Richard S.
Published: April 2007

Fiberoptic bronchoscopy has permitted the development of lavage procedures for the collection of lung washes. In certain disease states this material may contain large numbers of phagocytic cells (macrophages and neutrophils). Since these phagocytes are the predominant “dust scavenger cells” in the lung, the assessment of their particulate burden as well as that of the overall lavage material has been suggested as a potentially important diagnostic tool. The studies to date have shown that the presence of ferruginous bodies is an indication of past occupational exposure.

In the present study, a digestion procedure was carried out on bronchoalveolar lavage material collected from individuals who were occupationally exposed to asbestos and from samples obtained from the general population. The parameters used for distinguishing the source of these samples included both light microscopy assessment of the filters for the presence of ferruginous bodies and electron microscopic screening for the presence of uncoated fibers.
Carcinoma of the colon in asbestos‐exposed workers: Analysis of asbestos content in colon tissue
Authors: Ehrlich Albert , Gordon Ronald E. , Dikman Steven H.
Published: April 2007

Epidemiological studies have indicated an increased incidence of carcinoma of the colon in asbestos workers. The present study evaluated the colon tissue asbestos burden, by light and electron microscopic analytic techniques, in patients with a history of occupational asbestos exposure and colon cancer. Asbestos fibers and/or asbestos bodies were present in colon tissue from 14 of 44 (31.8%) asbestos workers with colon carcinoma (range 142,199 to 15,231, 543 fibers/g/wet weight, mean 2,517,823). Chrysotile was identified in 9 patients and amosite in 3 patients. Both amosite and chrysotile were found in the colonic wall in one individual. Other forms of asbestos (e.g., crocidolite, tremolite, or anthophyllite) were not found. Asbestos fibers and asbestos bodies were not found in colon tissue from 20 control patients (colon carcinoma and no asbestos exposure). Asbestos fibers frequently enter and reside in the wall of the colon and are often intimately associated with tumor tissue at the site of colon carcinoma in workers with asbestos exposure and colon carcinoma.
Acute occupational respiratory diseases in hospital discharge data
Authors: Kipen Howard M. , Gelperin Kate , Tepper Allison , Stanbury Martha
Published: April 2007

We investigated the feasibility of using hospital discharge diagnoses of ICD codes 506, 507, and 508, respiratory diseases from external sources, to identify occupational sentinel health events [SHE(O)]. Two hundred sixty‐nine records were reviewed and 66 (25%) were incidents where the work‐relatedness of the respiratory diseases was documented in the medical records. Twenty‐six percent of the 269 records contained no exposure information. Sixty‐four of the 66 occupational cases were from ICD codes 506.0‐506.9, with the largest number classified as ICD codes 506.0 (bronchitis and pneumonitis due to fumes and vapors) and 506.3 (other acute and subacute respiratory conditions due to fumes and vapors). We conclude that surveillance of ICD codes in the 506 series, where 39% of the cases were secondary to occupational exposures, is a valuable component of a surveillance system for preventable occupational lung disease.
The occupational cancer incidence surveillance study (OCISS): Risk of lung cancer by usual occupation and industry in the detroit metropolitan area
Authors: Burns Patricia Brissette , Swanson G. Marie
Published: April 2007

This case‐referent study assesses occupational risk factors associated with lung cancer, utilizing colon and rectum cancer referents. Complete occupational and tobacco use histories were obtained by telephone interview for 5,935 incident lung cancer cases and 3,956 incident colon and rectum cancer referents. The analysis included 43 usual occupational groups and 48 usual industry groups comprised of at least 10 cases. Among all cases, there were significant elevated risks for excavating and mining workers (OR = 4.01), furnace workers (OR = 3.11), armed services personnel (OR = 3.10), agricultural workers (OR = 2.05), driver sales (OR = 2.21), mechanics (OR = 1.72), painters (OR = 1.96), and drivers (OR = 1.88). Industries with significant elevated lung cancer risk included farming (OR = 2.21), mining (OR = 2.98), and primary ferrous metals manufacturing (OR = 2.43). Analyses of white and black men separately revealed that the excess of lung cancer among mechanics is restricted to black males (OR = 4.16). The risk of lung cancer among armed services personnel is higher among black men (OR = 10.54) than among white men (OR = 3.06). Five of the occupations observed more often among lung cancer cases have probable exposure to diesel exhaust.
Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations
Authors: Gianfrancesco Fernando , Cannella Milena , Martino Tiziana , Maglione Vittorio , Esposito Teresa , Innocenzi Gualtiero , Vitale Emilia , Liquori Christina L. , Marchuk Douglas A. , Squitieri Ferdinando
Published: April 2007

Cavernous vascular malformations may affect brain and out‐of‐brain tissues. In most cases, cerebral cavernous malformations (CCMs) involve the brain alone, and are rarely associated with skin hemangiomas, spinal cord, retinal, hepatic or vertebral lesions. CCMs can cause seizures, intracranial and spinal haemorrhages, focal neurological deficits, and migraine‐like headaches. After collecting CCM families of Italian origin and investigating the genetic basis of the disorder we disclosed two novel molecular variations in the KRIT1 and MGC4607 genes. We found a novel CCM1 gene mutation (Q66X) in a family with apparently asymptomatic old‐aged mutation carriers and patients who either had skin angiomas alone or the full association of cerebral, spinal, and skin lesions. In this family we report the highest variability in mutation penetrance so far described, including the presence of CCM in one subject since birth (surgery at 19 months of age), a condition to our knowledge so far unreported. In a CCM2 affected family, we also report a novel causative mutation, (54_55delAC) in exon 2 of the MGC4607 gene, that produces a truncated protein containing only 22 amino acids. These data describe novel CCM mutations associated with a particularly high variability of the penetrance causing, in some cases, reduced expression of clinical symptoms and sporadic cases with apparent negative family history. Hence they emphasize the importance of DNA‐based diagnostics and genetic counseling to identify unaffected mutation carriers subjects, even at advanced age. © 2007 Wiley‐Liss, Inc.
Tachykinin receptor 1 variants associated with aggression in suicidal behavior
Authors: Giegling Ina , Rujescu Dan , Mandelli Laura , Schneider Barbara , Hartmann Annette M. , Schnabel Axel , Maurer Konrad , De Ronchi Diana , Möller Hans‐Jürgen , Serretti Alessandro
Published: April 2007

Substance P is involved in the modulation of depression, anxiety, and suicidal‐related behaviors. We studied gene variants of Tachykinin Receptor 1 (TACR1—rs3771810, rs3771825, rs726506, rs1477157) in 167 German suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 Caucasian individuals who committed suicide and 312 German healthy subjects. Single markers and haplotype analysis in relation to suicidal behaviors (suicide attempters/completers) did not reveal any significant association. The rarest rs3771825 T allele however showed a marginal association with higher Reactive Aggression scores on the Questionnaire for Measuring Factors of Aggression (FAF) (F = 9.86, df = 1; P = 0.0017). Haplotype analyses confirmed the finding. Violence or impulsivity of suicide attempt and State‐Trait Anger Expression Inventory (STAXI) scores were not associated with gene variants. In conclusion, our study suggests that TACR1 gene variants have no major influence on suicidal behavior but may modulate aggression features. © 2007 Wiley‐Liss, Inc.
Do adolescents compromise their identity when chatting on the Internet?
Authors: Larraín M. Elena , Zegers Beatriz , Trapp Alejandro
Published: April 2007

This research project intended to explore the relation between internet chat room use and adolescent identity. The subjects of this research project were 124 first‐year university students of the Universidad de los Andes, Santiago, Chile. State of identity was measured by the Identity Consolidated Inventory (ICI) and identity‐compromise in chat rooms by the Phase Completion Test (TCF) scale. Gender differences were analyzed and men showed higher total scores in both instruments. The relation between identity‐integration and identity‐compromise project in chat rooms was confirmed. Some 11.3% of the subjects who had identity‐diffusion also compromised their identity while chatting. The causal relation between the two variables needs further research, and new definitions of identity require more study. Copyright © 2007 John Wiley & Sons, Ltd.
Atrazine and reproductive function: mode and mechanism of action studies
Authors: Cooper Ralph L. , Laws Susan C. , Das Parikshit C. , Narotsky Michael G. , Goldman Jerome M. , Lee Tyrey E. , Stoker Tammy E.
Published: April 2007

Atrazine, a chlorotriazine herbicide, is used to control annual grasses and broadleaf weeds. In this review, we summarize our laboratory's work evaluating the neuroendocrine toxicity of atrazine (and related chlorotriazines) from an historic perspective. We provide the rationale for our work as we have endeavored to determine: 1) the underlying reproductive changes leading to the development of mammary gland tumors in the atrazine‐exposed female rat; 2) the cascade of physiological events that are responsible for these changes (i.e., the mode of action for mammary tumors); 3) the potential cellular mechanisms involving adverse effects of atrazine; and 4) the range of reproductive alterations associated with this pesticide. Birth Defects Res (Part B), 2007. Published 2007 Wiley‐Liss, Inc.
Evaluation of aflatoxin B1 embryotoxicity using the frog embryo teratogenesis assay‐Xenopus and bio‐activation with microsome activation systems
Authors: Vismara Claudio , Caloni Francesca
Published: April 2007

BACKGROUND: Aflatoxins are a group of mycotoxins produced by Aspergillus, A. flavus, and A. parasiticus. Aflatoxin B1 (AFB1) should be a strong teratogen in hamsters, but its effect in rats is equivocal and extremely limited in mice. Therefore, the AFB1 embryotoxic potential in mammals remains unclear. METHODS: Little is known about the AFB1 effects on amphibians, therefore its embryotoxic potential was evaluated using the frog embryo teratogenesis assay‐Xenopus (FETAX). X. laevis blastulae were exposed to: 1) positive controls for bio‐activation (4 g/L cyclophosphamide monohydrate, Cy, and 4 g/L Cy+30 mg/L MAS‐rat; 4 g/L Cy+30 mg/L MAS‐human); 2) positive controls for MAS (30 mg/L MAS‐rat and 30 mg/L MAS‐human); 3) exposed groups to AFB1 (1 mg/L AFB1); and 4) AFB1 bio‐activation (1 mg/L AFB1+30 mg/L MAS‐rat and 1 mg/L AFB1+30 mg/L MAS‐human). RESULTS: In MAS‐rat and human, Cy did not induce a statistically significant increase of mortality and malformed larvae percentage, but when bio‐activated Cy increased the percentage of mortality. Instead, MAS‐rat and human alone did not show any increase of mortality and malformed larvae percentages. When bio‐activated by MAS‐rat and human, AFB1 increased significantly both the mortality and malformed larvae percentages. The malformed larvae were mainly plurimalformed, i.e., affected by generalized edema, abnormal gut coiling, and microphthalmia. CONCLUSIONS: This research shows that AFB1 alone is not embryotoxic but, when bio‐activated with MAS‐rat or MAS‐human the percentage of mortality and malformed larvae increased significantly. These results also show that AFB1 must be bio‐activated to exert its embryotoxic effects. Birth Defects Res (Part B) 80:1–5, 2007. © 2007 Wiley‐Liss, Inc.
Peptide design and structural characterization of a GPCR loop mimetic
Authors: Pham Truc‐Chi T. , Kriwacki Richard W. , Parrill Abby L.
Published: April 2007

G protein‐coupled receptors (GPCRs) control fundamental aspects of human physiology and behaviors. Knowledge of their structures, especially for the loop regions, is limited and has principally been obtained from homology models, mutagenesis data, low resolution structural studies, and high resolution studies of peptide models of receptor segments. We developed an alternate methodology for structurally characterizing GPCR loops, using the human S1P4first extracellular loop (E1) as a model system. This methodology uses computational peptide designs based on transmembrane domain (TM) model structures in combination with CD and NMR spectroscopy. The characterized peptides contain segments that mimic the self‐assembling extracellular ends of TM 2 and TM 3 separated by E1, including residues R3.28(121) and E3.29(122) that are required for sphingosine 1‐phosphate (S1P) binding and receptor activation in the S1P4receptor. The S1P4loop mimetic peptide interacted specifically with an S1P headgroup analog,O‐phosphoethanolamine (PEA), as evidenced by PEA‐induced perturbation of disulfide cross‐linked coiled‐coil first extracellular loop mimetic (CCE1a)1H and15N backbone amide chemical shifts. CCE1a was capable of weakly binding PEA near biologically relevant residues R29 and E30, which correspond to R3.28 and E3.29 in the full‐length S1P4receptor, confirming that it has adopted a biologically relevant conformation. We propose that the combination of coiled‐coil TM replacement and conformational stabilization with an interhelical disulfide bond is a general design strategy that promotes native‐like structure for loops derived from GPCRs. © 2007 Wiley Periodicals, Inc. Biopolymers 86: 298–310, 2007.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Stable isotope dilution analysis of N‐acetylaspartic acid in urine by liquid chromatography electrospray ionization tandem mass spectrometry
Authors: Al‐Dirbashi Osama Y. , Rashed Mohamed S. , Al‐Mokhadab Manhal A. , Al‐Qahtani Khalid , Al‐Sayed Moeen A. A. , Kurdi Wesam
Published: April 2007

N‐acetylaspartic acid (NAA) is a specific urinary marker for Canavan disease, an autosomal recessive leukodystrophy. We developed a ‘dilute and shoot’ stable isotope dilution liquid chromatography tandem mass spectrometry (LC‐MS/MS) method for determination of NAA in urine. Deuterated internal standard d3‐NAA was added to untreated urine and the mixture was injected into the LC‐MS/MS system operated in the negative ion mode. Chromatography was carried out on a C8 minibore column using 50% acetonitrile solution containing 0.05% formic acid at a flow rate of 0.25 mL/min. The retention time was 1.6 min and the turnaround time was 2.2 min. NAA and d3‐NAA were analyzed in multiple reaction monitoring mode. Calibrators and quality control samples were prepared in pooled control urine. The assay was linear up to 2000 µmol/L with limit of quantification at 1 µmol/L (S/N = 12). Interassay and intraassay coefficients of variation were less than 7% and recovery at three different concentrations was 98.9–102.5%. The LC‐MS/MS method for NAA as described involves no extraction and no derivatization, showed no interference and gave excellent recovery with low variability and short analytical time. The method was successfully applied for the retrospective analysis of urine from 21 Canavan disease cases. Copyright © 2007 John Wiley & Sons, Ltd.
Simultaneous determination of hydroxysafflor yellow A and ferulic acid in rat plasma after oral administration of the co‐extractum of Rhizoma chuanxiong and Flos Carthami by HPLC–diode array detector
Authors: Qi Jianping , Jin Xuefeng , Huang Luosheng , Ping Qineng
Published: April 2007

A simple, rapid and accurate HPLC method has been developed for simultaneous determination of hydroxysafflor yellow A and ferulic acid in rat plasma after oral administration of the co‐extractum of Rhizoma chuanxiong and Flos Carthami. Plasma samples were deproteinized with 6% perchloric acid, and riboflavin was used as internal standard. The supernatant after centrifuge was injected into a Shimadzu C18 (150 × 4.6 mm, i.d. 5 µm) column. Gradient elution for A:B (0 min, 90:10; 25 min, 70:30; 27 min, stop) was applied. The mobile phase was composed of 0.022 mol/L potassium dihydrogen phosphate solutions, adjusted to pH 3.0 with phosphoric acid for pump A, and 90% (v/v) acetonitrile for pump B. The assay was shown to be linear over the range 0.046–4.6 µg/mL (r2 = 0.9995) for hydroxysafflor yellow A and 0.037–3.7 µg/mL (r2 = 0.9998) for ferulic acid. Mean recovery was 97.5% for hydroxysafflor yellow A and 83.6% for ferulic acid. Both of the intra‐day and inter‐day precisions were ≤8.1%. The limits of quantification of hydroxysafflor yellow A and ferulic acid were 0.046 and 0.037 µg/mL, respectively. The HPLC method was successfully applied to the pharmacokinetic studies of hydroxysafflor yellow A and ferulic acid in rat plasma after oral administration of the co‐extractum of Rhizoma chuanxiong and Flos Carthami. Copyright © 2007 John Wiley & Sons, Ltd.
Resolution of oligosaccharides in glycopeptides using immobilized Endo‐M and ultra‐performance liquid chromatography with electrospray ionization time‐of‐flight mass spectrometry
Authors: Min Jun Zhe , Toyo'oka Toshimasa , Kurihara Takamasa , Kato Masaru , Fukushima Takeshi , Inagaki Shinsuke
Published: April 2007

The resolution of asparagine‐linked oligosaccharides in glycopeptides was carried out by combination of the transglycosylation reaction and ultra‐performance liquid chromatography with electrospray ionization time‐of‐flight mass spectrometry (UPLC‐ESI‐TOF‐MS). The resolution of the oligosaccharides is based on the enzymic transglycosylation reaction with Endo‐β‐N‐acetylglucosaminidase (Endo‐M) isolated from Mucor hiemalis. The oligosaccharides were transferred to a fluorescent acceptor (NDA‐Asn‐GlcNAc) with Endo‐M to produce the fluorescent oligosaccharides. In the present research, the enzyme was also immobilized in the well of a microassay plate by the sol–gel technique. The transglycosylation reaction was easily managed due to the immobilization. Furthermore, multiple use was possible by the encapsulated Endo‐M. The resulting fluorescent oligosaccharides were separated by UPLC and efficiently detected by ESI‐TOF‐MS. Several oligosaccharides in ovalbumin were successfully identified by the proposed procedure. Copyright © 2007 John Wiley & Sons, Ltd.
Hypnosis in complex trauma and breast cancer pain: a single case study
Authors: Kwan Priscilla S. K.
Published: April 2007

This case study addresses the effect of hypnosis on a range of problems associated with complex trauma (i.e. spouse abuse). It begins by exploring the specific symptoms that were generated in complex trauma and identifying that hypnosis is an appropriate treatment for these problems. A four‐phase framework of treatment, taking into consideration the specific features of complex trauma which are distinct from single‐episode or non‐interpersonal trauma, was adopted. Breast cancer pain, another source of distress to the client, was also discussed. The therapeutic outcomes are described with reference to data collected from pre‐, during and post‐treatment, as well as from verbal feedback regarding Ms S's feelings about the therapy. The results indicate that hypnosis incorporated in the four‐phase treatment framework could effectively eliminate the symptoms of complex trauma. Copyright © 2007 British Society of Experimental & Clinical Hypnosis. Published by John Wiley & Sons, Ltd.
Low‐Temperature Structural Transitions in the Phonon‐Glass Thermoelectric Material β‐Zn4Sb3: Ordering of Zn Interstitials and Defects.
Authors: Nylen Johanna , Lidin Sven , Andersson Magnus , Brummerstedt Iversen Bo , Liu Hongxue , Newman Nate , Haeussermann Ulrich
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Photoluminescent Properties of Eu3+, Tb3+ Activated M3Ln(PO4)3 (M: Sr, Ca; Ln: Y, La, Gd) Phosphors Derived from Hybrid Precursors.
Authors: Xiao Xiuzhen , Xu Shuai , Yan Bing
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phase Transitions Occurring upon Lithium Insertion—Extraction of LiCoPO4.
Authors: Bramnik Natalia N. , Nikolowski Kristian , Baehtz Carsten , Bramnik Kirill G. , Ehrenberg Helmut
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A (4,2)‐Connected Niobium Phosphate Na13Nb3P6O28F2 with a Unique 6.12‐Net Layer: Synthesis, Structure and Ion Exchange Properties.
Authors: Liu Guang‐Zhen , Zheng Shou‐Tian , Yang Guo‐Yu
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The First Actinyl Cyanide.
Authors: Berthet Jean‐Claude , Thuery Pierre , Ephritikhine Michel
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structure, Electrical Conducting and Thermal Expansion Properties of Ln0.6Sr0.4Co0.2Fe0.8O3 (Ln: La, Pr, Nd, Sm) Perovskite‐Type Complex Oxides.
Authors: Xu Qing , Huang Duan‐Ping , Chen Wen , Zhang Feng , Wang Bi‐Tao
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cymantrene‐Derived Monodentate Phosphites: New Ligands for Rh‐Catalyzed Enantioselective Hydrogenation.
Authors: Lyubimov Sergey E. , Davankov Vadim A. , Loim Nikolay M. , Popova Lyudmila N. , Petrovskii Pavel V. , Valetskii Petr M. , Gavrilov Konstantin N.
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dibutyltin Dimethoxide and BINAP×Silver(I) Complex‐Catalyzed Asymmetric Aldol Reaction of Alkenyl Trichloroacetates with Aldehydes.
Authors: Yanagisawa Akira , Ichikawa Toshikazu , Arai Takayoshi
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Condensation of Oxindole with Acetoacetic Ester and Acetylacetone.
Authors: Nam N. L. , Grandberg I. I.
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Clean and Selective Baeyer—Villiger Oxidation of Ketones with Hydrogen Peroxide Catalyzed by Sn‐Palygorskite.
Authors: Lei Ziqiang , Zhang Qinghua , Wang Rongmin , Ma Guofu , Jia Chengguo
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxidation of Alkenes by Oxodiperoxomolybdenum: Trialkyl(aryl)phosphine Oxide Complexes.
Authors: Altinis Kiraz Christine I. , Mora Luis , Jimenez Leslie S.
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Simple and Efficient Microwave‐Assisted Hydrogenation Reactions at Moderate Temperature and Pressure.
Authors: Vanier Grace S.
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Strecker Reaction of Phosphinoyl Ketoimines Catalyzed by in situ Prepared Chiral N,N′‐Dioxides.
Authors: Huang Jinglun , Liu Xiaohua , Wen Yuehong , Qin Bo , Feng Xiaoming
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Convenient New Procedure for Converting Primary Amides into Nitriles.
Authors: Kuo Chun‐Wei , Zhu Jia‐Liang , Wu Jen‐Dar , Chu Cheng‐Ming , Yao Ching‐Fa , Shia Kak‐Shan
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rhodium(I) Complexes with N‐Heterocyclic Carbenes Bearing a 2,3,4,5‐Tetraphenylphenyl and Its Higher Dendritic Frameworks.
Authors: Sato Hiromichi , Fujihara Tetsuaki , Obora Yasushi , Tokunaga Makoto , Kiyosu Junya , Tsuji Yasushi
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel and Highly Efficient Method for the Silylation of Alcohols with Hexamethyldisilazane (HMDS) Catalyzed by Recyclable Sulfonic Acid‐Functionalized Ordered Nanoporous Silica.
Authors: Zareyee Daryoush , Karimi Babak
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
BF3×Et2O‐Catalyzed Direct Carbon—Carbon Bond Formation of α‐EWG Ketene‐(S,S)‐Acetals and Alcohols and Synthesis of Unsymmetrical Biaryls.
Authors: Zhang Qian , Sun Shaoguang , Hu Jianglei , Liu Qun , Tan Jing
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ruthenium‐Catalyzed Linear‐Selective Allylic Alkylation of Allyl Acetates.
Authors: Kawatsura Motoi , Ata Fumio , Wada Shohei , Hayase Shuichi , Uno Hidemitsu , Itoh Toshiyuki
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Activity of Covalently Immobilized Grubbs—Hoveyda Type Catalyst Is Highly Dependent on the Nature of the Support Material.
Authors: Michalek Florian , Maedge Daniel , Ruehe Juergen , Bannwarth Willi
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemoselective Cross‐Metathesis Reaction Between Electron‐Deficient 1,3‐Dienes and Olefins.
Authors: Ferrie Laurent , Amans Dominique , Reymond Sebastien , Bellosta Veronique , Capdevielle Patrice , Cossy Janine
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regiospecific Addition of Alkyl and Allyl Groups to α,β‐Unsaturated Carbonyl Compounds with Trialkylboranes Through the Palladium Catalyst.
Authors: Park Chung Min , Han Sam Yong , Seo Nan Young , Byun Chang‐ho , Gyoung Young Soo
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bismuth(III) Oxychloride Procatalyst Based One‐Pot Multicomponent Synthesis of β′‐Acetamido‐β‐dicarbonyl Compounds with Special Reference to pref‐β′‐Acetamido‐β‐oxo Esters.
Authors: Ghosh Rina , Maiti Swarupananda , Ghosh Soumen , Mukherjee Alok K.
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Silver(I) N‐Heterocyclic Carbene‐Bridged Calix[4]arene Analogues as Efficient [60]Fullerene Receptors
Authors: Qin Dabin , Zeng Xianshun , Li Qingshan , Xu Fengbo , Song Haibin , Zhang Zheng‐Zhi
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Directed Reductive Amination of β‐Hydroxy‐ketones: Convergent Assembly of the Ritonavir/Lopinavir Core.
Authors: Menche Dirk , Arikan Fatih , Li Jun , Rudolph Sven
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Atom Transfer Carbonylation Using Ionic Liquids as Reaction Media.
Authors: Fukuyama Takahide , Inouye Takaya , Ryu Ilhyong
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Synthesis of Cyclopropylamines Starting from N‐Sulfinyl α‐Chloro Ketimines.
Authors: Denolf Bram , Mangelinckx Sven , Toernroos Karl W. , De Kimpe Norbert
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tin‐Free and Catalytic Radical Cyclizations.
Authors: Smith Deborah M. , Pulling Mary E. , Norton Jack R.
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
RuCl3‐Catalyzed Oxidation of Iodoarenes with Peracetic Acid: New Facile Preparation of Iodylarenes.
Authors: Koposov Alexey Y. , Karimov Rashad R. , Pronin Andrey A. , Skrupskaya Tatyana , Yusubov Mekhman S. , Zhdankin Viktor V.
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nucleophilic Substitution of Halogens with Amines in 2‐ and 4‐Nitrophenols.
Authors: Wrobel Zbigniew , Kwast Andrzej
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Copper(I)—Tetrahydrosalen‐Catalyzed Asymmetric Henry Reaction and Its Extension to the Synthesis of (S)‐Norphenylephrine.
Authors: Xiong Yan , Wang Fei , Huang Xiao , Wen Yuehong , Feng Xiaoming
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gallium‐Mediated Allyl Transfer from Bulky Homoallyl Alcohol to Aldehydes or Alkynes: Control of Dynamic σ‐Allylgalliums Based on Retro‐Allylation Reaction.
Authors: Hayashi Sayuri , Hirano Koji , Yorimitsu Hideki , Oshima Koichiro
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemo‐ and Regioselective Reductive Opening of Azetidinium Ions.
Authors: Couty Francois , David Olivier , Durrat Francois
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Halogen—Lithium Exchange versus Deprotonation: Synthesis of Diboronic Acids Derived from Aryl—Benzyl Ethers.
Authors: Klis Tomasz , Serwatowski Janusz
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Environmentally Benign Oxidation Reaction of Benzylic and Allylic Alcohols to Carbonyl Compounds Using Pd/C with Sodium Borohydride.
Authors: An Gwangil , Lim Minkyung , Chun Kwon‐Soo , Rhee Hakjune
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Indium(I) Bromide Promoted Stereoselective Preparation of (E)‐α,β‐Unsaturated Ketones via Sequential Intermolecular Aldol‐Type Coupling/Elimination Reactions of α,α‐Dichloroketones with Aldehydes.
Authors: Peppe Clovis , das Chagas Rafael Pavao
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Aluminum Phthalocyanine: An Active and Simple Catalyst for Cyanosilylation of Ketones.
Authors: Rajagopal Gurusamy , Kim Sung Soo , Kwak Ju Myung
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Enantioselective Cyanoformylation of Aldehydes Catalyzed by a Mononuclear Salen‐Ti(OiPr)4 Complex Produced in situ.
Authors: Chen Shi‐Kui , Peng Dan , Zhou Hui , Wang Li‐Wei , Chen Fu‐Xue , Feng Xiao‐Ming
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Symmetric Diallyl Disulfides from Baylis—Hillman Acetates.
Authors: Cha Myeong Jong , Song Young Seok , Lee Kee‐Jung
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemoselective Mono Halogenation of β‐Keto‐sulfones Using Potassium Halide and Hydrogen Peroxide; Synthesis of Halomethyl Sulfones and Dihalomethyl Sulfones.
Authors: Suryakiran N. , Prabhakar P. , Reddy T. Srikanth , Mahesh K. Chinni , Rajesh K. , Venkateswarlu Y.
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Catalytic Asymmetric Synthesis of trans‐5‐Aryl‐2‐substituted Cyclohexanones by Rhodium‐Catalyzed Conjugate Arylation of Racemic 6‐Substituted Cyclohexenones.
Authors: Chen Qian , Soeta Takahiro , Kuriyama Masami , Yamada Ken‐ichi , Tomioka Kiyoshi
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
DAB‐Cy as an Inexpensive and Effective Ligand for Palladium‐Catalyzed Homocoupling Reaction of Aryl Halides.
Authors: Ma Ning , Duan Zheng , Wu Yangjie
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reaction of CpCo(PPh3)2 with Diphenylphosphinoalkynes: Syntheses and X‐Ray Structures of 1,3‐Cyclobutadiene‐Substituted CpCoCb Diphosphine and 2,5‐Cobaltacyclopentadiene Diphosphine Dioxide.
Authors: Chang Chin‐Pei , Kultyshev Roman G. , Hong Fung‐E
Published: April 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.