bluuebunny/crossref_metadata_2025 huggingface dataset:
Tedizolid Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-Analysis
Authors: Lan Shao-Huan , Lin Wei-Ting , Chang Shen-Peng , Lu Li-Chin , Chao Chien-Ming , Lai Chih-Cheng , Wang Jui-Hsiang
Published: September 2019

This meta-analysis aims to assess the efficacy and safety of tedizolid, compared to linezolid, in the treatment of acute bacterial skin and skin structure infection (ABSSSI). PubMed, Web of Science, EBSCO (Elton B. Stephens Co.), Cochrane Library, Ovid Medline and Embase databases were accessed until 18 July 2019. Only randomized controlled trials (RCTs) comparing the efficacy of tedizolid with linezolid for adult patients with ABSSSIs were included. The outcomes included the clinical response, microbiological response, and risk of adverse events (AEs). A total of four RCTs involving 2056 adult patients with ABSSSI were enrolled. The early clinical response rate was 79.6% and 80.5% for patients receiving tedizolid and linezolid, respectively. The pooled analysis showed that tedizolid had a non-inferior early clinical response rate to linezolid (odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.77–1.19, I2 = 0%). The early response rate was similar between tedizolid and linezolid among patients with cellulitis/erysipelas (75.1% vs. 77.1%; OR = 0.90, 95% CI = 0.64–1.27, I2 = 25%), major cutaneous abscess (85.1% vs. 86.8%; OR = 0.93, 95% CI = 0.42–2.03, I2 = 37%) and wound infection (85.9% vs. 82.6%; OR = 1.29, 95% CI = 0.66–2.51, I2 = 45%). For methicillin-resistant Staphylococcus aureus patients, tedizolid had a favorable microbiological response rate of 95.2% which was comparable to linezolid (94%) (OR = 1.19, 95% CI = 0.49–2.90, I2 = 0%). In addition to the similar risk of treatment-emergent AEs (a serious event, the discontinuation of the study drug due to AEs and mortality between tedizolid and linezolid), tedizolid was associated with a lower risk of nausea, vomiting and abnormal neutrophil count than linezolid. In conclusion, once-daily tedizolid (200 mg for six days) compared to linezolid (600 mg twice-daily for 10 days) was non-inferior in efficacy in the treatment of ABSSSI. Besides, tedizolid was generally as well tolerated as linezolid, and had a lower incidence of gastrointestinal AEs and bone marrow suppression than linezolid.
Bacteriophages as Alternatives to Antibiotics in Clinical Care
Authors: Romero-Calle Danitza , Guimarães Benevides Raquel , Góes-Neto Aristóteles , Billington Craig
Published: September 2019

Antimicrobial resistance is increasing despite new treatments being employed. With a decrease in the discovery rate of novel antibiotics, this threatens to take humankind back to a “pre-antibiotic era” of clinical care. Bacteriophages (phages) are one of the most promising alternatives to antibiotics for clinical use. Although more than a century of mostly ad-hoc phage therapy has involved substantial clinical experimentation, a lack of both regulatory guidance standards and effective execution of clinical trials has meant that therapy for infectious bacterial diseases has yet to be widely adopted. However, several recent case studies and clinical trials show promise in addressing these concerns. With the antibiotic resistance crisis and urgent search for alternative clinical treatments for bacterial infections, phage therapy may soon fulfill its long-held promise. This review reports on the applications of phage therapy for various infectious diseases, phage pharmacology, immunological responses to phages, legal concerns, and the potential benefits and disadvantages of this novel treatment.
Vibro-Acoustic Performance of a Sandwich Plate with Periodically Inserted Resonators
Authors: Guo Zhiwei , Pan Jie , Sheng Meiping
Published: September 2019

The vibro-acoustic performance of a sandwich plate with periodic locally resonant (LR) units is examined in this paper, with specific focus on the effect of periodic resonators on the average radiation efficiency and the acoustic radiation to the far field. In order to assess the radiation performance, the band-gap properties of an infinite periodic structure and the vibrational response of a finite periodic structure are first studied with closed-form solutions. Subsequently, the acoustic radiation efficiency of the LR sandwich plate is obtained using the concepts of modal radiation. It is shown that the acoustic radiation power can be reduced significantly, not only in the band-gap but also at frequencies close below the band-gap, due to either the decrease in radiation efficiency or the decrease in the vibration response. Thus, the periodic resonators provide a broader attenuation band for the purposes of noise reduction than for vibration reduction. However, for frequencies close above the band-gap, the acoustic performance became worse, owing to the increase in acoustic radiation efficiency. Fortunately, the increased sound radiation above the band-gap can be reduced by adding a small damping to the resonator, which further broadens the attenuation frequency band. The reason for the variation of acoustic radiation efficiency is also studied and can be physically explained by the effective mass of an LR unit, where increased mass corresponds to decreased radiation efficiency and decreased mass corresponds to increased radiation efficiency. Thus, the effective mass can be a useful parameter for designers to estimate which frequency component will be acoustically reduced or acoustically enhanced in a practical design.
Improvement of the Cardiac Oscillator Based Model for the Simulation of Bundle Branch Blocks
Authors: Cardarilli Gian Carlo , Di Nunzio Luca , Fazzolari Rocco , Re Marco , Silvestri Francesca
Published: September 2019

In this paper, we propose an improvement of the cardiac conduction system based on three modified Van der Pol oscillators. Each oscillator represents one of the components of the heart conduction system: Sino-Atrial node (SA), Atrio-Ventricular node (AV) and His–Purkinje system (HP). However, while SA and AV nodes can be modelled through a single oscillator, the modelling of HP by using a single oscillator is a rough simplification of the cardiac behaviour. In fact, the HP bundle is composed of Right (RB) and Left Bundle (LB) branches that serve, respectively, the right and left ventricles. In order to describe the behaviour of each bundle branch, we build a phenomenological model based on four oscillators: SA, AV, RB and LB. For the characterization of the atrial and ventricular muscles, we used the modified FitzHugh–Nagumo (FHN) equations. The numerical simulation of the model has been implemented in Simulink. The simulation results show that the new model is able to reproduce the heart dynamics generating, besides the physiological signal, also the pathological rhythm in case of Right Bundle Branch Block (RBBB) and Left Bundle Branch Block (LBBB). In particular, our model is able to describe the communication interruption of the conduction system, when one of the HP bundle branches is damaged.
Development of an Evaluation System for Magnetic Resonance Imaging Based Three-Dimensional Modeling of a Transfemoral Prosthetic Socket Using Finite Elements
Authors: Jamaludin Mohd Syahmi , Hanafusa Akihiko , Shinichirou Yamamoto , Agarie Yukio , Otsuka Hiroshi , Ohnishi Kengo
Published: September 2019

Recent technologies have suggested the utilization of three-dimensional (3D) printing technology to enhance the fabrication accuracy of prosthetics. Accordingly, simulations are used to obtain precise parameters for subject-specified prosthetic socket. This study proposes an evaluation system to measure the accuracy of a subject-specific 3D transfemoral residuum model during the interaction with the socket in conjunction with the application of finite element methods. The proposed system can be used in future validations of socket fabrication. The evaluation is based on the measurement of the residuum’s soft tissue deformation inside two types of prosthetic sockets. In comparison with other studies, the 3D models were constructed with magnetic resonance images (MRI) with the aid of computer-aided design (CAD) software. The measurement of soft tissue deformation was conducted based on the measurement of the volumetric value of fat, muscle and skin in the pre- and post-donning phases. The result yielded a promising correlation coefficient value between the simulation and the experiment in the soft tissue deformation evaluation. The relation of the muscle–fat ratio in the residuum is extremely important in the determination of the ability of the prosthetic to deform. The environment during the socket fitting session was similar to that defined by the set boundary conditions in simulations. In view of the promising results of this study, the evaluation system proposed herein is considered reliable and is envisaged to be used in future research.
Landslide Susceptibility Prediction Using Particle-Swarm-Optimized Multilayer Perceptron: Comparisons with Multilayer-Perceptron-Only, BP Neural Network, and Information Value Models
Authors: Li Deying , Huang Faming , Yan Liangxuan , Cao Zhongshan , Chen Jiawu , Ye Zhou
Published: September 2019

Landslides are one type of serious geological hazard which cause immense losses of local life and property. Landslide susceptibility prediction (LSP) can be used to determine the spatial probability of landslide occurrence in a certain area. It is important to implement LSP for landslide hazard prevention and reduction. This study developed a particle-swarm-optimized multilayer perceptron (PSO-MLP) model for LSP implementation to overcome the drawbacks of the conventional gradient descent algorithm and to determine the optimal structural parameters of MLP. Shicheng County in Jiangxi Province of China was used as the study area. In total, 369 landslides, randomly selected non-landslides, and 14 landslide-related predisposing factors were used to train and test the present PSO-MLP model and three other comparative models (an MLP-only model with the gradient descent algorithm, a back-propagation neural network (BPNN), and an information value (IV) model). The results showed that the PSO-MLP model had the most accurate prediction performance (area under the receiver operating characteristic curve (AUC) of 0.822 and frequency ratio (FR) accuracy of 0.856) compared with the MLP-only (0.791 and 0.829), BPNN (0.800 and 0.840), and IV (0.788 and 0.824) models. It can be concluded that the proposed PSO-MLP model addresses the drawbacks of the MLP-only model well and performs better than conventional artificial neural networks (ANNs) and statistical models. The spatial probability distribution law of landslide occurrence in Shicheng County was well revealed by the landslide susceptibility map produced using the PSO-MLP model. Furthermore, the present PSO-MLP model may have higher prediction and classification performances in some other fields compared with conventional ANNs and statistical models.
Acceptance Model for Mobile Building Information Modeling (BIM)
Authors: Hong Sim-Hee , Lee Seul-Ki , Kim In-Han , Yu Jung-Ho
Published: September 2019

Mobile Building Information Modeling (BIM) is noted for tools that enable the systematic interchange of information and contribute to enhancing collaborative performance through BIM. BIM programs, which are continuously available in the mobile environment, have been developed. Moreover, in some sites, mobile BIM is applied to generate benefits in projects. Various efforts are being made to use mobile BIM; however, its utilization is low. Also, mobile BIM has lacked an analysis of the factors that affect actual users’ acceptance of mobile BIM. Therefore, this study analyzes the factors that affect the acceptance of mobile BIM by construction practitioners and presents the association of factors as a model to activate mobile BIM use. To this end, this study analyzed a literature review for suggesting the factors that were expected to affect mobile BIM acceptance. The assessment items were decided based on the analysis result. Second, 111 copies were received by surveying the construction practitioners. Third, it identified factors that significantly affected the acceptance of mobile BIM and proposed models through factor analysis and structural equation models. Finally, based on the analysis, it presented the findings. This study expects to contribute to enhanced acceptance of mobile BIM technology by managing the significant factors properly. Also, it is expected that the result can be used to develop a variety of mobile BIM that is more easily acceptable to them. This study presented a model for accepting mobile BIM based on the survey results of Korean practitioners; therefore, it is necessary to explore ways to generalize the model in the future.
Thermal-Performance Evaluation of Bicycle Helmets for Convective and Evaporative Heat Loss at Low and Moderate Cycling Speeds
Authors: Mukunthan Shriram , Vleugels Jochen , Huysmans Toon , Kuklane Kalev , Mayor Tiago Sotto , De Bruyne Guido
Published: September 2019

The main objective of the study was to investigate the thermal performance of five (open and closed) bicycle helmets for convective and evaporative heat transfer using a nine-zone thermal manikin. The shape of the thermal manikin was obtained by averaging the 3D-point coordinates of the head over a sample of 85 head scans of human subjects, obtained through magnetic resonance imaging (MRI) and 3D-printed. Experiments were carried out in two stages, (i) a convective test and (ii) an evaporative test, with ambient temperature maintained at 20.5 ± 0.5 °C and manikin skin temperature at 30.5 ± 0.5 °C for both the tests. Results showed that the evaporative heat transfer contributed up to 51%–53% of the total heat loss from the nude head. For the convective tests, the open helmet A1 having the highest number of vents among tested helmets showed the highest cooling efficiency at 3 m/s (100.9%) and at 6 m/s (101.6%) and the closed helmet (A2) with fewer inlets and outlets and limited internal channels showed the lowest cooling efficiency at 3 m/s (75.6%) and at 6 m/s (84.4%). For the evaporative tests, the open helmet A1 showed the highest cooling efficiency at 3 m/s (97.8%), the open helmet A4 showed the highest cooling efficiency at 6 m/s (96.7%) and the closed helmet A2 showed the lowest cooling efficiency at 3 m/s (79.8%) and at 6 m/s (89.9%). Two-way analysis of variance (ANOVA) showed that the zonal heat-flux values for the two tested velocities were significantly different (p < 0.05) for both the modes of heat transfer. For the convective tests, at 3 m/s, the frontal zone (256–283 W/m2) recorded the highest heat flux for open helmets, the facial zone (210–212 W/m2) recorded the highest heat flux for closed helmets and the parietal zone (54–123 W/m2) recorded the lowest heat flux values for all helmets. At 6 m/s, the frontal zone (233–310 W/m2) recorded the highest heat flux for open helmets and the closed helmet H1, the facial zone (266 W/m2) recorded the highest heat flux for the closed helmet A2 and the parietal zone (65–123 W/m2) recorded the lowest heat flux for all the helmets. For evaporative tests, at 3 m/s, the frontal zone (547–615 W/m2) recorded the highest heat flux for all open helmets and the closed helmet H1, the facial zone (469 W/m2) recorded the highest heat flux for the closed helmet A2 and the parietal zone (61–204 W/m2) recorded the lowest heat flux for all helmets. At 6 m/s, the frontal zone (564–621 W/m2) recorded highest heat flux for all the helmets and the parietal zone (97–260 W/m2) recorded the lowest heat flux for all helmets.
Reframing the Horizon within the Algorithmic Landscape of Northern Britain
Authors: Goodfellow Paul
Published: September 2019

Emerging from the artist’s constructed photographs and walking projects in the north, this paper considers the tension between the photograph as a fixed composition of the world and the dynamic image constructed from data. Whereas arguably, the traditional photograph exhibits a stable relationship between the world and the image, the constructed photograph shifts the focus onto the underlying algorithmic processes of production. This focus on the relational nature of the constructed photograph shifts our gaze from the horizon to the underlying systems in operation as we consider the relational nature of data as a photograph.
Statistical Characteristics of Major Sudden Stratospheric Warming Events in CESM1-WACCM: A Comparison with the JRA55 and NCEP/NCAR Reanalyses
Authors: Cao Can , Chen Yuan-Hao , Rao Jian , Liu Si-Ming , Li Si-Yu , Ma Mu-Han , Wang Yao-Bin
Published: September 2019

Using the historical simulation from the CESM1-WACCM coupled model and based on the JRA55 and NCEP/NCAR reanalyses, the general statistical characteristics of the major sudden stratospheric warmings (SSWs) in this stratosphere-resolving model are assessed. The statistical and diagnostic results show that CESM1-WACCM can successfully reproduce the frequency of SSW events. As in the JRA55 and NCEP/NCAR reanalyses, five or six SSW events, on average, occur in a model decade. The seasonal distribution of SSWs is also well simulated with the highest frequency in January (35%). The unprecedented low SSW frequency observed in 1990s from the two reanalyses is also identified in a model decade (1930s). In addition, the overestimated duration of SSW events in the earlier WACCM version is not identified in CESM1-WACCM when compared with the two reanalyses. The model can well reproduce the downward propagation of the stratospheric anomaly signals (i.e., zonal wind, height, temperature) following SSWs. Both the modelling and observational evidences indicate that SSWs are proceeded by the positive Pacific–North America (PNA) and negative Western Pacific (WP) pattern. The negative North Atlantic Oscillation (NAO) develops throughout the SSW life cycle, which is successfully modeled. A cold Eurasian continent–warm North American continent pattern is observed before SSWs at 850 h Pa, while the two continents are anomalously cold after SSWs in both the reanalyses and the model.
Cloud Processing of Aerosol Particles in Marine Stratocumulus Clouds
Authors: Flossmann Andrea I. , Wobrock Wolfram
Published: September 2019

Cloud processing of aerosol particles is an important process and is, for example, thought to be responsible for the so-called “Hoppel-minimum” in the marine aerosol particle distribution or contribute to the cell organization of marine boundary layer clouds. A numerical study of the temporal and spatial scales of the processing of aerosol particles by typical marine stratocumulus clouds is presented. The dynamical framework is inspired by observations during the VOCALS (Variability of the American Monsoon System Ocean-Cloud-Atmosphere-Land Study) Regional Experiment in the Southeast Pacific. The 3-D mesoscale model version of DESCAM (Detailed Scavenging Model) follows cloud microphysics of the stratocumulus deck in a bin-resolved manner and has been extended to keep track of cloud-processed particles in addition to non-processed aerosol particles in the air and inside the cloud drops. The simulation follows the evolution of the processing of aerosol particles by the cloud. It is found that within one hour almost all boundary layer aerosol particles have passed through at least one cloud cycle. However, as the in-cloud residence times of the particles in the considered case are only on the order of minutes, the aerosol particles remain essentially unchanged. Our findings suggest that in order to produce noticeable microphysical and dynamical effects in the marine boundary layer clouds, cloud processing needs to continue for extended periods of time, exceeding largely the time period considered in the present study. A second model study is dedicated to the interaction of ship track particles with marine boundary layer clouds. The model simulates quite satisfactorily the incorporation of the ship plume particles into the cloud. The observed time and spatial scales and a possible Twomey effect were reproduced.
On Certain Axiomatizations of Arithmetic of Natural and Integer Numbers
Authors: Wybraniec-Skardowska Urszula
Published: September 2019

The systems of arithmetic discussed in this work are non-elementary theories. In this paper, natural numbers are characterized axiomatically in two different ways. We begin by recalling the classical set P of axioms of Peano’s arithmetic of natural numbers proposed in 1889 (including such primitive notions as: set of natural numbers, zero, successor of natural number) and compare it with the set W of axioms of this arithmetic (including the primitive notions like: set of natural numbers and relation of inequality) proposed by Witold Wilkosz, a Polish logician, philosopher and mathematician, in 1932. The axioms W are those of ordered sets without largest element, in which every non-empty set has a least element, and every set bounded from above has a greatest element. We show that P and W are equivalent and also that the systems of arithmetic based on W or on P, are categorical and consistent. There follows a set of intuitive axioms PI of integers arithmetic, modelled on P and proposed by B. Iwanuś, as well as a set of axioms WI of this arithmetic, modelled on the W axioms, PI and WI being also equivalent, categorical and consistent. We also discuss the problem of independence of sets of axioms, which were dealt with earlier.
New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities
Authors: Cieślak Marcin , Kaźmierczak-Barańska Julia , Królewska-Golińska Karolina , Napiórkowska Mariola , Stukan Iga , Wojda Urszula , Nawrot Barbara
Published: September 2019

We identified novel dicarboximides that were selectively cytotoxic towards human leukemia cells. Using chemical and biological methods, we characterized the biological activity, identified cellular protein targets and defined the mechanism of action of the test dicarboximides. The reported IC50 values (concentration required to reduce cell survival fraction to 50% of control) of selected dicarboximides were similar or lower than IC50 of registered anticancer drugs, for example cytarabine, sorafenib, irinotecan. Test compounds induced apoptosis in chronic myelogenous (K562) and acute lymphoblastic (MOLT-4) leukemia cells by activation of receptor and mitochondrial apoptotic pathways and increased the expression of proapoptotic genes (BAX, NOXA, HTRA2, TNFRSF10B, ESRRBL1). Selected dicarboximides displayed immunomodulatory activity and downregulated IKZF1 and IKZF3 transcription factors in K562 and MOLT-4 leukemia cells. ATP-binding cassette protein 50 (ABC50) was identified as a target for dicarboximides. Cancer cells with knocked down ABC50 showed increased resistance to dicarboximides. Based on the structure of dicarboximides and thalidomide, novel proteolysis-targeting chimeras (PROTACs) were synthesized and used as tools to downregulate ABC50 in leukemia cells.
Modeling the Kinetic Behavior of Reactive Oxygen Species with Cerium Dioxide Nanoparticles
Authors: Reed Kenneth , Bush Nathan , Burns Zachary , Doherty Gwendolyn , Foley Thomas , Milone Matthew , L. Maki Kara , Cromer Michael
Published: September 2019

The world of medicinal therapies has been historically, and remains to be, dominated by the use of elegant organic molecular structures. Now, a novel medical treatment is emerging based on CeO2 nano-crystals that are discrete clusters of a few hundred atoms. This development is generating a great deal of exciting and promising research activity, as evidenced by this Special Issue of Biomolecules. In this paper, we provide both a steady-state and time-dependent mathematical description of a sequence of reactions: superoxide generation, superoxide dismutase, and hydrogen peroxide catalase and ceria regeneration. This sequence describes the reactive oxygen species (ROS); superoxide, O2–, molecular oxygen, O2, hydroxide ion OH– and hydrogen peroxide, H2O2, interacting with the Ce3+, and Ce4+ surface cations of nanoparticle ceria, CeO2. Particular emphasis is placed on the predicted time-dependent role of the Ce3+/Ce4+ ratio within the crystal. The net reaction is succinctly described as: H2O2 + 2O2– + 2H+ → 2H2O + 2O2. The chemical equations and mathematical treatment appears to align well with several critical in vivo observations such as; direct and specific superoxide dismutase (SOD), ROS control, catalytic regeneration, ceria self-regulation and self-limiting behavior. However, in contrast to experimental observations, the model predicts that the 4+ ceric ion state is the key SOD agent. Future work is suggested based on these calculations.
Newly Designed Human-Like Collagen to Maximize Sensitive Release of BMP-2 for Remarkable Repairing of Bone Defects
Authors: Chen Zhuoyue , Zhang Zhen , Ma Xiaoxuan , Duan Zhiguang , Hui Junfeng , Zhu Chenhui , Zhang Donggang , Fan Daidi , Shang Lijun , Chen Fulin
Published: September 2019

Designing the “ideal” hydrogel/matrix which can load bone morphogenetic protein-2 (BMP-2) in a low dose and with a sustained release is the key for its successful therapeutic application to enhance osteogenesis. The current use of natural collagen sponges as hydrogel/matrix is limited due to the collagen matrix showing weak mechanical strength and unmanageable biodegradability. Furthermore, the efficiency and safe dose usage of the BMP-2 has never been seriously considered other than purely chasing the lowest dose usage and extended-release time. In this paper, we customized a novel enzymatically cross-linked recombinant human-like collagen (HLC) sponge with low immunogenicity, little risk from hidden viruses, and easy production. We obtained a unique vertical pore structure and the porosity of the HLC, which are beneficial for Mesenchymal stem cells (MSCs) migration into the HLC sponge and angiopoiesis. This HLC sponge loading with low dose BMP-2 (1 µg) possessed high mechanical strength along with a burst and a sustained release profile. These merits overcome previous limitations of HLC in bone repair and are safer and more sensitive than commercial collagens. For the first time, we identified that a 5 µg dose of BMP-2 can bring about the side effect of bone overgrowth through this sensitive delivery system. Osteoinduction of the HLC-BMP sponges was proved by an in vivo mouse ectopic bone model and a rat cranial defect repair model. The method and the HLC-BMP sponge have the potential to release other growth factors and aid other tissue regeneration. Additionally, the ability to mass-produce HLC in our study overcomes the current supply shortage, which limits bone repair in the clinic.
Cerebral Blood Flow Regulation in Pregnancy, Hypertension, and Hypertensive Disorders of Pregnancy
Authors: Jones-Muhammad Maria , Warrington Junie P.
Published: September 2019

The regulation of cerebral blood flow (CBF) allows for the metabolic demands of the brain to be met and for normal brain function including cognition (learning and memory). Regulation of CBF ensures relatively constant blood flow to the brain despite changes in systemic blood pressure, protecting the fragile micro-vessels from damage. CBF regulation is altered in pregnancy and is further altered by hypertension and hypertensive disorders of pregnancy including preeclampsia. The mechanisms contributing to changes in CBF in normal pregnancy, hypertension, and preeclampsia have not been fully elucidated. This review summarizes what is known about changes in CBF regulation during pregnancy, hypertension, and preeclampsia.
The Relationship between Imaging-Based Body Composition Analysis and the Systemic Inflammatory Response in Patients with Cancer: A Systematic Review
Authors: Abbass Tanvir , Dolan Ross D , Laird Barry J , McMillan Donald C
Published: September 2019

Background and aim: Cancer is the second leading cause of death globally. Nutritional status (cachexia) and systemic inflammation play a significant role in predicting cancer outcome. The aim of the present review was to examine the relationship between imaging-based body composition and systemic inflammation in patients with cancer. Methods: MEDLINE, EMBASE, Cochrane Library and Google Scholar were searched up to 31 March 2019 for published articles using MESH terms cancer, body composition, systemic inflammation, Dual energy X-ray absorptiometry (DEXA), magnetic resonance imaging (MRI), ultrasound sonography (USS) and computed tomography (CT). Studies performed in adult patients with cancer describing the relationship between imaging-based body composition and measures of the systemic inflammatory response were included in this review. Results: The literature search retrieved 807 studies and 23 met the final eligibility criteria and consisted of prospective and retrospective cohort studies comprising 11,474 patients. CT was the most common imaging modality used (20 studies) and primary operable (16 studies) and colorectal cancer (10 studies) were the most commonly studied cancers. Low skeletal muscle index (SMI) and systemic inflammation were consistently associated; both had a prognostic value and this relationship between low SMI and systemic inflammation was confirmed in four longitudinal studies. There was also evidence that skeletal muscle density (SMD) and systemic inflammation were associated (9 studies). Discussion: The majority of studies examining the relationship between CT based body composition and systemic inflammation were in primary operable diseases and in patients with colorectal cancer. These studies showed that there was a consistent association between low skeletal muscle mass and the presence of a systemic inflammatory response. These findings have important implications for the definition of cancer cachexia and its treatment.
Microstructure and Microhardness of Ni/Al-TiB2 Composite Coatings Prepared by Cold Spraying Combined with Postannealing Treatment
Authors: Chen Xiao , Li Chengdi , Xu Shunjian , Hu Yao , Ji Gangchang , Wang Hongtao
Published: September 2019

Ni/Al-TiB2 composite powders were deposited on the surface of 316L stainless-steel substrates by cold spraying at gas temperatures of 250 and 450 °C, respectively. Then, the as-sprayed coatings were annealed at 650 °C for 10, 20, and 30 h. The experimental results showed that the average porosity of as-sprayed coating dropped from about 0.68% to 0.054% as the cold spraying gas temperature increased. The contents of Ni, Al, and TiB2 in the as-sprayed coatings were different from that of the Ni/Al-TiB2 composite powders. The main phase compositions of the as-sprayed Ni/Al-TiB2 coatings were the same as those of composite powder, consisting only of pure Ni, Al, and TiB2 phases. TiB2 as a reinforced particle in the as-sprayed coating could obviously increase the microhardness of the coatings. NiAl3 and Ni2Al3 intermetallic compounds were synthesized in situ in all of the annealed coatings, and the average contents of NiAl3 and Ni2Al3 intermetallic compounds increased as the cold spraying gas temperature increased. The distribution of TiB2 particle was changed as the annealing times increased, which changed from more comparative uniform distribution to accumulation. The average porosity of the annealed coatings increased as the annealing time increased. The microhardness of Ni/Al-TiB2 coatings annealed at 650 °C for 10 h was increased remarkably due to the reinforcement role of TiB2 particles and NiAl3 and Ni2Al3 intermetallic compounds.
Synthesis, Characterization, and Crystal Structure Determination of a New Lithium Zinc Iodate Polymorph LiZn(IO3)3
Authors: Hebboul Zoulikha , Galez Christine , Benbertal Djamal , Beauquis Sandrine , Mugnier Yannick , Benmakhlouf Abdelnour , Bouchenafa Mohamed , Errandonea Daniel
Published: September 2019

Synthesis and characterization of anhydrous LiZn(IO3)3 powders prepared from an aqueous solution are reported. Morphological and compositional analyses were carried out by using scanning electron microscopy and energy-dispersive X-ray measurements. The synthesized powders exhibited a needle-like morphology after annealing at 400 °C. A crystal structure for the synthesized compound was proposed from powder X-ray diffraction and density-functional theory calculations. Rietveld refinements led to a monoclinic structure, which can be described with space group P21, number 4, and unit-cell parameters a = 21.874(9) Å, b = 5.171(2) Å, c = 5.433(2) Å, and β = 120.93(4)°. Density-functional theory calculations supported the same crystal structure. Infrared spectra were also collected, and the vibrations associated with the different modes were discussed. The non-centrosymmetric space group determined for this new polymorph of LiZn(IO3)3, the characteristics of its infrared absorption spectrum, and the observed second-harmonic generation suggest it is a promising infrared non-linear optical material.
A Fifteen-Year Analysis of Rare Isolated Fallopian Tube Torsions in Adolescent Children: A Case Series
Authors: Güney Cengiz , Coskun Abuzer
Published: September 2019

Isolated tubal torsions presenting to the emergency department are a very rare cause of pediatric acute abdominal pain. Since making the diagnosis early is of importance in terms of affecting tubal damage and fertility, we aimed to evaluate cases of isolated tubal torsions in light of the literature. This study included 10 patients under 18 years of age who presented to the emergency department with abdominal pain between January 2003 and December 2018. The mean age was 14.5 ± 1.43 years (range: 12–17 years). The demographic characteristics, surgical findings and techniques, and concomitant pathology results of these patients were retrospectively evaluated. The reason for presenting to the emergency department for the 10 patients included in the study was abdominal pain. The mean duration of hospital admission with pain was 4.97 days. The onset of pain was less than 24 h in seven patients (70%) and more than 24 h in three patients (30%). Of the patients, nine (90%) had tenderness in the lower abdominal quadrant, five (5%) had defense, and three (30%) had rebound. Nausea, vomiting and leukocytosis were present in 50% of the cases. Right and left tubal involvement of the cases was equal. Seven (70%) of the isolated tubal torsions were accompanied by paraovarian cysts. Eight patients (80%) underwent open surgery and two (20%) underwent laparoscopic intervention. Detorsion was performed on five (50%) patients and salpingectomy was performed on five (50%) patients. Isolated tubal torsion should be considered in children presenting with acute abdominal pain in early adolescence. Early diagnosis is important for the preservation of fertility.
Early Diagnosis on Oral and Potentially Oral Malignant Lesions: A Systematic Review on the VELscope® Fluorescence Method
Authors: Cicciù Marco , Cervino Gabriele , Fiorillo Luca , D’Amico Cesare , Oteri Giacomo , Troiano Giuseppe , Zhurakivska Khrystyna , Lo Muzio Lorenzo , Herford Alan Scott , Crimi Salvatore , Bianchi Alberto , Di Stasio Dario , Rullo Rosario , Laino Gregorio , Laino Luigi
Published: September 2019

The fluorescence method is an innovative technique used by pathologists for examining body mucosa, and for the abnormalities tissue screening, potentially leading to the earlier discovery of pre-cancer, cancer or other disease processes. The early detection is one of the best mechanisms for enabling treatment success, increasing survival rates and maintaining a high quality of life. The purpose of this review is to evaluate the clinical efficiency of this diagnostic tool applied to the oral cavity (VELscope®). A literature systematic review has been performed. The initial research provided 53 results after applying the inclusion and exclusion criteria, and after a manual screening of the abstracts by the authors, only 25 results were eligible for review. The results and data contained in all the researches, no older than 10 years, were manually evaluated, and provided useful information on this diagnostic method. The VELscope® mean value about sensitivity and specificity resulted of 70.19% and 65.95%, respectively, by results analysis, but despite this some studies disagree about its clinical effectiveness, and this diagnostic method is still much debated in scientific and clinical medical literature. Surely being able to have efficient and effective tools from this point of view could help the clinician in the diagnosis, and also make timelier the pharmacological or surgical therapy, improving the quality of life of the patient, and in some cases guaranteeing a longer survival term.
Large Eddy Simulations of the Flow Fields over Simplified Hills with Different Roughness Conditions, Slopes, and Hill Shapes: A Systematical Study
Authors: Liu Zhenqing , Hu Yiran , Wang Wei
Published: September 2019

Turbulent flow fields over topographies are important in the area of wind energy. The roughness, slope, and shape of a hill are important parameters affecting the flow fields over topographies. However, these effects are always examined separately. The systematic investigations of these effects are limited, the coupling between these effects is still unrevealed, and the turbulence structures as a function of these effects are still unclear. Therefore, in the present study, the flow fields over twelve simplified isolated hills with different roughness conditions, slopes, and hill shapes are examined using large eddy simulations. The mean velocities, velocity fluctuations, fractional speed-up ratios, and visualizations of the turbulent flow fields are presented. It is found that as the hill slope increases, the roughness effects become weaker, and the roughness effects will further weaken as the hill changes from 3D to 2D. In addition, the fractional speed-up ratio at the summit of rough hills can even reach to three times as large as that over the corresponding smooth hills. Furthermore, the underestimation of the ratios of spanwise fluctuation to the streamwise fluctuation by International Electrotechnical Commission (IEC) 61400-1 is quite obvious when the hill shape is 3D. Finally, coherent turbulence structures can be identified for smooth hills, and as the hill slope increases, the coherent turbulence structures will experience clear evolutions. After introducing the ground roughness, the coherent turbulence structures break into small eddies.
Differential Responses to Climate and Land-Use Changes in Threatened Chinese Taxus Species
Authors: Wang Jianming , Wang Yin , Feng Jianmeng , Chen Chen , Chen Jie , Long Ting , Li Junqing , Zang Runguo , Li Jingwen
Published: September 2019

Rapid climate and land-use changes have been considered as the foremost threat to global biodiversity. China contains more than 3500 threatened higher plants, whereas the relative influence of climate and land-use changes on these endangered plants have not been explored simultaneously under topographical constraints. Here, using Taxus plants as the case study genus, we simulated the distribution range of threatened species under three scenarios of current and future climate and land-use conditions under topographical constraints. We also measured the associated difference in the responses of Taxus species to climate and land-use changes. Our results demonstrated the substantial influence of climate and land-use changes on the distributions of Taxus species. However, we observed different responses of Taxus species to these environmental changes. The distribution range of T. cuspidate Siebold & Zuccarini and T. mairei Lemee & H. Léveillé would substantially shrink, whereas the habitat range of T. fuana Nan Li & R. R. Mill would sharply expand under RCP 8.5(Representative Concentration Pathway scenarios) scenario. Meanwhile, T. wallichiana Zuccarini and T. chinensis (Pilger) Florin would experience apparent range shifts. Furthermore, topographical factors played non-negligible roles in shaping species distributions, and modifying the influence of climate and land-use changes. Together, these results provide robust evidence that even threatened species will have multiple responses to climate and land-use changes (e.g., shrinking, expanding, shifting). Our findings highlight that taking species ecological traits, habitat characteristics, and topographical constraints into account might provide valuable insights into threatened species conservation in the face of global environmental changes.
Monitoring of a Seedling Planting Restoration in a Permanent Preservation Area of the Southeast Atlantic Forest Biome, Brazil
Authors: Fiore Nathalia V. , Ferreira Carolina C. , Dzedzej Maíra , Massi Klécia G.
Published: September 2019

The Atlantic Forest biome is a biodiversity hotspot with only 13% of its native vegetation cover remaining in Brazil. Forest restoration is an important process for the re-establishment of biodiversity and the preservation of water resources in degraded areas, like riparian forests. Monitoring is an essential step of restoration, because the periodic evaluation of indicators allows researchers to analyze the effectiveness of applied techniques. This study aimed to evaluate the environmental quality of a seedling planting (active restoration) in a Permanent Preservation Area (PPA) of the Southeast Atlantic Forest biome, through a monitoring protocol, within a year. More specifically, we aimed to investigate the following questions: (1) do some ecological groups or families grow more than others? and (2) is the cover of exotic grasses negatively influencing forest regeneration? Data were collected during November 2017 and April (interval represents five months of wet season) and October 2018 (six months of dry season). Eight plots of 9 × 18 m were established and all individuals were identified and measured (diameter at ground level (DGL), height (H), and canopy diameter (CD)). Exotic grass cover and richness of regenerating species were also recorded. We registered 119 individuals during the three inventories, distributed in 35 species and 14 families. Results indicate an inverse association between exotic grasses and the presence of recruits in the area. Thus, exotic grass control may be needed while the forest canopy is not closed. A significant growth of individuals in the whole study period, especially during the wet season, was detected. Legumes grew more in trunk and canopy diameter (Anadenanthera colubrina (Vell.) Brenan and Inga vera Willd. subsp. affinis (DC.) T. D. Penn. had the biggest growth, respectively) than non-legumes during wetter months and within a year. Pioneers had greater height increase compared to non-pioneers only during wetter months. Legumes may be important species to be used in other young tropical forest restoration areas.
Molecular Strategies for RPGR Gene Therapy
Authors: Cehajic Kapetanovic Jasmina , McClements Michelle E , Martinez-Fernandez de la Camara Cristina , MacLaren Robert E
Published: September 2019

Mutations affecting the Retinitis Pigmentosa GTPase Regulator (RPGR) gene are the commonest cause of X-linked and recessive retinitis pigmentosa (RP), accounting for 10%–20% of all cases of RP. The phenotype is one of the most severe amongst all causes of RP, characteristic for its early onset and rapid progression to blindness in young people. At present there is no cure for RPGR-related retinal disease. Recently, however, there have been important advances in RPGR research from bench to bedside that increased our understanding of RPGR function and led to the development of potential therapies, including the progress of adeno-associated viral (AAV)-mediated gene replacement therapy into clinical trials. This manuscript discusses the advances in molecular research, which have connected the RPGR protein with an important post-translational modification, known as glutamylation, that is essential for its optimal function as a key regulator of photoreceptor ciliary transport. In addition, we review key pre-clinical research that addressed challenges encountered during development of therapeutic vectors caused by high infidelity of the RPGR genomic sequence. Finally, we discuss the structure of three current phase I/II clinical trials based on three AAV vectors and RPGR sequences and link the rationale behind the use of the different vectors back to the bench research that led to their development.
How Well can Spaceborne Digital Elevation Models Represent a Man-Made Structure: A Runway Case Study
Authors: Becek Kazimierz , Akgül Volkan , Inyurt Samed , Mekik Çetin , Pochwatka Patrycja
Published: September 2019

In this case study, an active runway of a civilian airport in Zonguldak, Turkey was used to assess the suitability of spaceborne digital elevation models (DEMs) to model an anthropogenic structure. The tested DEMs include the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), the Advanced Land Observing Satellite (ALOS) World 3D 30 m (AW3D30), the Shuttle Radar Topography Mission (SRTM)-1”, the SRTM-3”, the SRTM-X, the TanDEM-3”, and the WorldDEMTM. A photogrammetric high accuracy DEM was also available for the tests. As a reference dataset, a line-leveling survey of the runway using a Leica Sprinter 150/150M instrument was performed. The selection of a runway as a testbed for this type of investigation is justified by its unique characteristics, including its flat surface, homogenous surface material, and availability for a ground survey. These characteristics are significant because DEMs over similar structures are free from environment- and target-induced error sources. For our test area, the most accurate DEM was the WorldDEMTM followed by the SRTM-3” and TanDEM-3”, with vertical errors (LE90) equal to 1.291 m, 1.542 m, and 1.56 m, respectively. This investigation uses a method, known as the runway method, for identifying the vertical errors in DEMs.
Youth Willingness to Purchase Whole Grain Snack Packs from New York City Corner Stores Participating in a Healthy Retail Program
Authors: Leak Tashara M. , Setiono Felicia , Gangrade Navika , Mudrak Erika
Published: September 2019

Corners stores in low-income communities are a promising setting to intervene in youth whole grain intake. One strategy that may encourage whole grain intake is if corner stores were to pair and sell whole grain snacks in combination with either a liked fruit or vegetable and an optional condiment (i.e., a whole grain snack pack). This study examined youth in terms of their (1) liking of fruits, vegetables, and whole grain snacks; (2) perceptions about which fruits and vegetables pair best with whole grain snacks; and (3) willingness to pay for a whole grain snack pack. One-time intercept surveys were conducted with 10–18-year-olds (n = 402) who visited a New York City (NYC) corner store (n = 34) participating in the City Harvest Healthy Retail Program. On average, youth were willing to spend $2.38 (SD $4.32) on a whole grain snack pack. Higher overall liking scores for vegetables and whole grain snacks were associated with willingness to spend 24.4% (95% confidence interval (CI): 11.5–38.7%) and 21.6% (95%CI: 5.2–40.6%) more on whole grain snack packs, respectively. In conclusion, youth are receptive to purchasing whole grain snack packs from NYC corner stores participating in a healthy retail program.