bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Kejadian ISPA pada Anak di Puskesmas Sukaraya Kecamatan Baturaja Timur Kabupaten OKU Tahun 2021
Authors: Atmaja Chairi , Gustina Erma , Eka Anggreny Dian
Published: January 2023

Acute respiratory infection (ARI) is still a major health problem and is the leading cause of death and mortality in the world, including in Indonesia. The purpose of this study was to describe the incidence of ARI. Methods This study uses a cross sectional design conducted at the Sukaraya Health Center, Baturaja Timur District, OKU Regency in August 2021 with a total sample of 104 respondents. The results of the bivariate analysis in this study obtained the mother's education variable p-value 0.555, knowledge p-value 0.000, mosquito venom use p-value 0.000, smoking p-value 0.932, history of breastfeeding p-value 0.011, ventilation p-value 0.005. The results of the multivariate analysis showed that the knowledge variable p-Value was 0.000 (<0.05) with OR=10,815. It can be said that there is a significant relationship between the use of mosquitoes, history of breastfeeding and ventilation with the incidence of ARI, while for the mother's education variable, there is no relationship related to the incidence of ARI. The more dominant variable in this study is the knowledge variable.
Analisis Kepatuhan Petugas Laboratorium dalam Penggunaan Alat Pelindung Diri (APD) di Laboratorium BTKLPP Kelas I Palembang Tahun 2021
Authors: Yandiono Pradani , Dwi Priyatno Akhmad , Eka Anggreny Dian
Published: January 2023

Workers safety is one of success indicator in an organization system. This system must be stated in a policy and lowered into standard operating procedures (SOP). Workers safety must be obeyed by all relevant officers involved that job to insure work safety. This study to identify the factors related to compliance of laboratory officers in use Personal Protective Equipment (PPE). This research was used survey method to measure the independent and dependent variables. The analysis used is the chi-square test. This research was conducted on 12 – 26 July 2021 using questionnaire instrument to 23 respondents (laboratory officers) with total sampling technique. This study showed that the average respondent’s was 38 years old. The female respondent was 23 (65.7%), education respondent’s was 18 (41.4%) bachelor degree, working time respondent’s was 32 (91.4%), the availability of facilities was not available 18 (51.4 %), poor supervision 20 (57.1%), good knowledge respondent’s was 33 (94.3%), negative attitude was 19 (54.3%) and compliance 19 (54.3%). The conclusion of this research is that there is a relationship between the variables of gender, supervision of laboratory officer compliance in using PPE and there is not relationship between the education, working time respondent’s. knowledge, attitudes, availability of facilities and age on the laboratory officer compliance in use PPE at BTKLPP Class I Laboratory. Suggestions for BTKLPP class I to carry out socialization and education on product operational standards using PPE, to complete the facilities and availability of personal safety equipment and supervision in use PPE to ensure occupational health and safety.
The Effect of Heat Therapy on the Severity of Restless Legs Syndrome and Sleep Quality in the Elderly
Authors:   Research Centre for Nursing and Midwifery Care, School of Nursing and Midwifery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Azizkhani Hojjat , Nazmieh Hossein ,   Department of Nursing, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Dehghani Arefeh ,   Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Nasiriani Khadijeh ,   Department of Nursing, Research Centre for Nursing and Midwifery Care, Mother and Newbern Health  Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Published: January 2023

Objective Restless legs syndrome is a neurological condition associated with an irresistible urge to move the legs and eventually leads to discomfort, sleep disorders, and reduced quality of life. Restless legs syndrome is common in the elderly, whose health improvement is an important healthcare issue. This study aimed to determine the effect of hot water bags on the severity of restless legs syndrome and sleep quality in the elderly. Methods The study has a quasi-experimental design. In this research, 88 elderly people were selected based on purposive sampling. Then they were randomly assigned to the experimental (n=44) and control (n=44) groups. The intervention group received a hot water bag on the leg, and the control group received routine care. Data collection tools were the demographic questionnaire, the restless legs syndrome rating scale, and the Pittsburgh sleeps quality index. The questionnaires were completed as a self-report. Data were analyzed with the independent t test and paired t test using SPSS. Results The Mean±SD scores of restless legs syndrome were 16.7±0.46 in the experimental group and 16.50±1.17 in the control group before the intervention, which was not significantly different (P=0.32). The Mean±SD scores of restless legs syndrome were 10.68±1.52 in the experimental group and 15.55±1.79 in the control group after the intervention, which was significantly different (P=0.0001). In addition, the mean ± SD scores of sleep quality were 8.3±1.5 and 10.42±1.89 in the control group and the experimental group after the intervention, which showed a significant difference (P=0.0001). Conclusion Findings showed that the hot water bag application reduces the severity of restless legs syndrome and improves sleep quality. Therefore, a hot water bag is especially recommended for the elderly, as it is cheap, accessible, and acceptable.
Effect of Spiritual Self-care Education on the Resilience of Nurses Working in the Intensive Care Units Dedicated to COVID-19 Patients in Iran
Authors:   Department of Nursing, Faculty of Paramedicine, Tehran University of Medical Sciences, Tehran, Iran., Mirzaee Sajjad , Bekmaz Karvan ,   Clinical Research Development Center of Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran., Rasooli Aziz ,   Department of Emergency Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Shamsi Afzal ,   Department of Intelligence, Faculty of Paramedicine, Tehran University of Medical Sciences, Tehran, Iran.
Published: January 2023

Objective: Nurses experienced many psychological problems during the COVID-19 outbreak. Considering that spirituality can be a strong factor in controlling stressful situations, this study aims to investigate the effect of spiritual self-care education on the resilience of nurses working in intensive care units (ICUs) dedicated to patients with COVID-19 in Iran. Methods: This experimental study was conducted on 64 nurses working in ICUs dedicated to patients with COVID-19 in Ziaeian Hospital in Tehran, Iran in 2021 who were selected by a census method and then randomly (by coin toss) assigned to the intervention (n=32) and control (n=32) groups. The intervention group received the spiritual self-care education at 6 sessions of 45 minutes every other day. Data were collected using a demographic form and the Connor-Davidson resilience scale and entered in SPSS software, version 25 and analyzed using independent t-test, paired t-test, and chi-square test. The significant level was set at 0.05. Results: The Mean±SD score of resilience before the education in the intervention and control groups were 48.0±5.28 and 46.44±6.05, respectively. The difference was not statistically significant (P=0.275). After the education, the mean of resilience in the intervention and control groups were 74.65±3.35, 49.38±6.49 respectively. The difference was statistically significant (P<0.0001). Conclusion: It is suggested that spiritual self-care education should be provided to nurses in ICUs dedicated to patients with COVID-19 to improve their resilience and thus help them provide better services to patients.
Effect of Eight Weeks of High Intensity Interval Training and Crocin Consumption on Serum Markers of Dox-induced Cardiotoxicity in Male Wistar Rats
Authors:   Department of Physical Education, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran., Ahmadi Qaracheh Razieh , Fathi Mohammad ,   Department of Physical Education, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran., Rahmati Masoud ,   Department of Physical Education, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran.
Published: January 2023

Objective: Doxorubicin (Dox) is a very effective drug for the treatment of a wide range of cancers. However, in healthy tissues, especially cardiac tissue, it can lead to cytotoxicity. This study aims to determine the effect of 8 weeks of high intensity interval training (HIIT) and crocin consumption on serum markers of Dox-induced cardiotoxicity in male rats Methods: In this study, 32 male Wistar rats were randomly divided into four groups: healthy control, doxorubicin, doxorubicin + HIIT, and doxorubicin + crocin + HIIT. The HIIT program was performed for 8 weeks, five days a week, with two 2-min intervals and 80% intensity in the first week and eight 2-minute intervals and 90% intensity of maximum speed in the final weeks. The last group received 10 mg/kg body weight of crocin by gavage for 8 weeks. Dox was injected subcutaneously seven times at a dose of 2 mg/kg. Forty-eight hours after the last training session and after anesthesia, blood samples were taken directly from the left ventricle; after separating serum from plasma, the levels of lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CK-MB) were measured. Data were analyzed using independent t-test and one-way analysis of variance. The significance level was set at 0.05. Results: The Dox injection led to a significant increase in LDH and CK-MB levels in rats compared to the healthy control group (P=0.001). However, 8 weeks of HIIT significantly reduced the serum levels of LDH (P=0.001) and CK-MB (P=0.017) compared to the Dox group. In addition, 8 weeks of HIIT plus crocin consumption significantly reduced the LDH (P=0.001) and CK-MB (P=0.001) levels compared to the Dox group. There was no significant difference between the effects of HIIT alone and HIIT plus crocin consumption on the serum levels of LDH (P=0.087) and CK-MB (P=0.877) in rats received doxorubicin. Conclusion: It seems that HIIT alone and in combination with crocin consumption can reduce the changes in serum levels of LDH and CK-MB induced by doxorubicin.
Effect of Aromatherapy With Rosemary Essential Oil on Preoperative Anxiety, Stress, Depression and Physiological Parameters in Candidates For General Surgery: A Clinical Trial
Authors:   Department of Nursing, Faculty of Medical Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran., Madadkar Dehkordi Shirin
Published: January 2023

Objective: Anxiety and stress are among the most common mental problems in patients before surgery. This study aims to determine the effect of aromatherapy with rosemary essential oil on preoperative anxiety, stress, depression and physiological parameters in candidates for general surgery. Methods: In this clinical trial, 60 candidates for general surgery at Ayatollah Kashani Hospital in Shahrekord, Iran in 2019 were randomly divided into two groups of aromatherapy (n=30) and control (n=30). In the aromatherapy group, on the day of surgery, one hour before going to the operating room, three drops of 10% rose essential oil were poured on a tissue and pinned to the patients’ pillows, and they were asked to smell it for 20 minutes. There was no intervention in the control group. Data collection tools were a demographic form, the 21-item depression anxiety stress scale, and vital signs checklist. Data were analyzed in SPSS software, version 21 using chi-square test and paired t-test. Results: Before the intervention, the mean scores of anxiety, stress, and depression in the aromatherapy group were 16.80, 17.77, and 16.27, respectively, where the difference in these three variables was not significant (P>0.05). After the intervention, their mean scores were 15.03, 15.57, and 15.83, respectively, where the difference in these variables was significant (P<0.05). There was a significant difference in these variables between the two groups (P<0.05). Conclusion: Aromatherapy with rosemary essential oil can reduce anxiety, stress, depression and improve some physiological indicators of patients before general surgery. Therefore, it is recommended to use it along with modern medicine.
Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System
Authors: Naumenko Natalia V. , Petruseva Irina O. , Lavrik Olga I.
Published: January 2023

The nucleotide excision repair (NER) system removes a wide range of bulky DNA lesions that cause significant distortions of the regular double helix structure. These lesions, mainly bulky covalent DNA adducts, are induced by ultraviolet and ionizing radiation or the interaction between exogenous/endogenous chemically active substances and nitrogenous DNA bases. As the number of DNA lesions increases, e.g., due to intensive chemotherapy and combination therapy of various diseases or DNA repair impairment, clustered lesions containing bulky adducts may occur. Clustered lesions are two or more lesions located within one or two turns of the DNA helix. Despite the fact that repair of single DNA lesions by the NER system in eukaryotic cells has been studied quite thoroughly, the repair mechanism of these lesions in clusters remains obscure. Identification of the structural features of the DNA regions containing irreparable clustered lesions is of considerable interest, in particular due to a relationship between the efficiency of some antitumor drugs and the activity of cellular repair systems. In this review, we analyzed data on the induction of clustered lesions containing bulky adducts, the potential biological significance of these lesions, and methods for quantification of DNA lesions and considered the causes for the inhibition of NER-catalyzed excision of clustered bulky lesions.
A Low-Molecular-Weight BDNF Mimetic, Dipeptide GSB-214, Prevents Memory Impairment in Rat Models of Alzheimer’s Disease
Authors: Povarnina Polina Yu. , Volkova Anna A. , Vorontsova Olga N. , Kamensky Andrey A. , Gudasheva Tatiana A. , Seredenin Sergey B.
Published: January 2023

Brain-derived neurotrophic factor (BDNF) is known to be involved in the pathogenesis of Alzheimers disease (AD). However, the pharmacological use of full-length neurotrophin is limited, because of its macromolecular protein nature. A dimeric dipeptide mimetic of the BDNF loop 1, bis-(N-monosuccinyl-L-methionyl-L-serine) heptamethylene diamide (GSB-214), was designed at the Zakusov Research Institute of Pharmacology. GSB-214 activates TrkB, PI3K/AKT, and PLC-1 in vitro. GSB-214 exhibited a neuroprotective activity during middle cerebral artery occlusion in rats when administered intraperitoneally (i.p.) at a dose of 0.1 mg/kg and improved memory in the novel object recognition test (0.1 and 1.0 mg/kg, i.p.). In the present study, we investigated the effects of GSB-214 on memory in the scopolamine- and steptozotocin-induced AD models, with reference to activation of TrkB receptors. AD was modeled in rats using a chronic i.p. scopolamine injection or a single streptozotocin injection into the cerebral ventricles. GSB-214 was administered within 10 days after the exposure to scopolamine at doses of 0.05, 0.1, and 1 mg/kg (i.p.) or within 14 days after the exposure to streptozotocin at a dose of 0.1 mg/kg (i.p.). The effect of the dipeptide was evaluated in the novel object recognition test; K252A, a selective inhibitor of tyrosine kinase receptors, was used to reveal a dependence between the mnemotropic action and Trk receptors. GSB-214 at doses of 0.05 and 0.1 mg/kg statistically significantly prevented scopolamine-induced long-term memory impairment, while not affecting short-term memory. In the streptozotocin-induced model, GSB-214 completely eliminated the impairment of short-term memory. No mnemotropic effect of GSB-214 was registered when Trk receptors were inhibited by K252A.
Multiple Sclerosis Is Associated with Immunoglobulin Germline Gene Variation of Transitional B Cells
Authors: Lomakin Yakov A. , Ovchinnikova Leyla A. , Zakharova M. N. , Ivanova M. V. , Simaniv T. O. , Kabilov M. R. , Bykova N. A. , Mukhina V. S. , Kaminskaya A. N. , Tupikin A. E. , Zakharova M. Y. , Favorov A. V. , Illarioshkin S. N. , Belogurov A. A. , Gabibov A. G.
Published: January 2023

The regulatory functions of the B-cell compartment play an important role in the development and suppression of the immune response. Disruption of their anti-inflammatory functions may lead to the acceleration of immunopathological processes, and to autoimmune diseases, in particular. Unfortunately, the exact mechanism underlying the functioning and development of regulatory B cells (Breg) has not yet been fully elucidated. Almost nothing is known about their specificity and the structure of their B-cell receptors (BCRs). In this research, we analyzed the BCR repertoire of the transitional Breg (tBreg) subpopulation with the CD19+CD24highCD38high phenotype in patients with multiple sclerosis (MS), using next-generation sequencing (NGS). We show, for the first time, that the immunoglobulin germline distribution in the tBreg subpopulation is different between MS patients and healthy donors. The registered variation was more significant in patients with a more severe form of the disease, highly active MS (HAMS), compared to those with benign MS (BMS). Our data suggest that during MS development, deviations in the immunoglobulin Breg repertoire occur already at the early stage of B-cell maturation, namely at the stage of tBregs: between immature B cells in the bone marrow and mature peripheral B cells.
Comparison of the Effectiveness of Transepidemal and Intradermal Immunization of Mice with the Vacinia Virus
Authors: Shchelkunov Sergei N. , Sergeev Aleksander A. , Titova Ksenia A. , Pyankov Stepan A. , Starostina Ekaterina V. , Borgoyakova Maria B. , Kisakova Lubov A. , Kisakov Denis N. , Karpenko Larisa I. , Yakubitskiy Stanislav N.
Published: January 2023

The spread of the monkeypox virus infection among humans in many countries outside of Africa, which started in 2022, is now drawing the attention of the medical and scientific communities to the fact that immunization against this infection is sorely needed. According to current guidelines, immunization of people with the first-generation smallpox vaccine based on the vaccinia virus (VACV) LIVP strain, which is licensed in Russia, should be performed via transepidermal inoculation (skin scarification, s.s.). However, the long past experience of using this vaccination technique suggests that it does not ensure virus inoculation into patients skin with enough reliability. The procedure of intradermal (i.d.) injection of a vaccine can be an alternative to s.s. inoculation. The effectiveness of i.d. vaccination can depend on the virus injection site on the body. Therefore, the aim of this study was to compare the development of the humoral and cellular immune responses in BALB/c mice immunized with the LIVP VACV strain, which was administered either by s.s. inoculation or i.d. injection into the same tail region of the animal. A virus dose of 105 pfu was used in both cases. ELISA of serum samples revealed no significant difference in the dynamics and level of production of VACV-specific IgM and IgG after i.d. or s.s. vaccination. A ELISpot analysis of splenocytes from the vaccinated mice showed that i.d. administration of VACV LIVP to mice induces a significantly greater T-cell immune response compared to s.s. inoculation. In order to assess the protective potency, on day 45 post immunization, mice were intranasally infected with lethal doses of either the cowpox virus (CPXV) or the ectromelia virus (ECTV), which is evolutionarily distant from the VACV and CPXV. Both vaccination techniques ensured complete protection of mice against infection with the CPXV. However, when mice were infected with a highly virulent strain of ECTV, 50% survived in the i.d. immunized group, whereas only 17% survived in the s.s. immunized group. It appears, therefore, that i.d. injection of the VACV can elicit a more potent protective immunity against orthopoxviruses compared to the conventional s.s. technique.
Estimación de la densidad básica de la madera en tres especies tropicales en Chiapas, México
Authors:   Universidad Autónoma de Chiapas, México, Marroquín-Morales Pablo , Alanís-Rodríguez Eduardo ,   Universidad Autónoma de Nuevo León, México, Aguirre-Calderón Oscar Alberto , Pimienta de la Torre Dorian de Jesús
Published: January 2023

It has now been shown that the basic density of wood is related to tree growth and carbon storage capacity, it also providesinformation such as the resistance, durability and quality of the wood, with this, the efficient use of wood in tropical species isdetermined. The objective of this research was to estimate the basic density of wood in three tropical species (Tectona grandis L. f.,Gmelina arborea Roxb. and Cedrela odorata L.). To estimate the basic density of the species, the empirical method was used,which consists of extracting a core from the tree using a pressler drill, at a breast height (1.30 m), once the 20 cores per specieshave been obtained, the small samples are dehydrated in a drying oven until a constant temperature is obtained, through this thebasic density per species was obtained. Once the density data was obtained they were subjected to an analysis of variance and latera Tukey test was applied. The statistical analysis indicates that, if there are significant differences between the species, where thehighest basic density occurred in Tectona grandis L. f. with 0.59 g/cm³, followed by Gmelina arborea Roxb. 0.44 g/cm³ and finallyCedrela odorata L. with 0.37 g/cm³, these values according to the wood classification indicate that teak and melina have mediumwood and cedar has low wood
Estrategias volitivas empleadas por los estudiantes universitarios en los diferentes estilos de aprendizaje
Authors: Juárez Díaz Catalina , Rodríguez Guardado María del Socorro
Published: January 2023

El objetivo de esta investigación fue identificar las estrategias volitivas que ponen en marcha los estudiantes universitarios con diferentes estilos de aprendizaje. Para ello, se reconocieron los estilos de aprendizaje, se distinguieron las estrategias volitivas y se determinaron las diferentes estrategias volitivas que utilizan los estudiantes de distintos estilos de aprendizaje. El estudio fue cualitativo, se empleó el método fenomenológico para comprender las experiencias del estudiantado al utilizar las estrategias volitivas de acuerdo con su estilo de aprendizaje. Participaron 47 mujeres (58 %) y 34 hombres (42 %) de una universidad pública del estado de Puebla, en edades entre 18 y 48 años (M = 21.67; SD = 4.91). Se entrevistó a 18 estudiantes. Para identificar los estilos de aprendizaje se empleó el cuestionario CHAEA y la entrevista, previamente validada, contempló cuatro categorías: Control de la motivación, Control de la emoción, Control del comportamiento y Control del ambiente. Los resultados obtenidos muestran que las estrategias más empleadas por los estudiantes fueron las de comportamiento, seguidas por las de motivación y emoción. Las menos mencionadas fueron las de control del ambiente...
Intrinsic factors for decreasing role of libraries in information activities
Authors: Stepanov V. K.
Published: January 2023

Digital transformation of document arrays has changed the nature of information infrastructure, as the digital documents are created, distributed, discovered and delivered in principally other way than in the epoch of printed matters as the main information media. The transition to digital information infrastructure has resulted in the loss of role of libraries as an essential intermediate on the document author-to-reader way, reasonably displacing libraries to the periphery of information activities and depreciating the majority of methods and technologies of document array organization developed through the centuries. The author substantiates the rationale for degrading information component of library mission and the necessity to transit to prevalent analytical services. The decreasing role of libraries is determined by the following factors: reduction of overall printed publications; their lower contextual value; capabilities to store, distribute, process digital information array formally and semantically, information deliver to users without the input of librarian. Therefore, not all the manual processing operations have become demanded any more. The print arrays grow scanty quantitively and contextually, and the increasing and dynamical digital flows are processed by ever-improving software. The author sees the solution in expanding analytical function of libraries which envisages inclusion of professional competences related to complex analytical processes, i. e. fact search and verification; acquisition and processing of statistical and experimental research data, preparation of analytical surveys, reviews and reports.
Axiological aspects of transforming library profession in the aspect of professional education
Authors: Babieva N. A. , Maslova Y. V. , Matveeva G. V.
Published: January 2023

Technological evolution of the civilization have been increasingly define the integrated global landscape and contribute to political, economic, social and ecological changes. Innovative high-speed communication systems and wide access to information consolidate the states, economies and businesses in the more sophisticated way one can envision. This global interdependence bears the risks of increasing social and economic inequity; in particular, due to instability and social unsustainability of the weaker economies. The authors discuss the problems of the library profession digitalization affecting the transformation of library education as the condition for preserving and developing human resources in librarianship. They insist that training librarians should comply with the requirements to modern libraries. They specify the key professional competences for library specialists of a new breed, and suggest prospective vectors of training at library departments.
Dissertations as important scientific legacy: Preservation and access (the case study of the Library of N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences)
Authors: Evdokimenkova Yu. B. , Soboleva N. O.
Published: January 2023

The authors discuss the preservation of dissertations by national scientists in the libraries of the Russian Academy of Sciences (RAS) research institutions. A share of theses defended in the Russian Empire before 1918 makes the part of the general collection. Since 1934, the scholarly manuscripts havebeen spinned off into a separate collection, since 1950, along with theses abstracts. The dissertations were transferred to the organizations where they were defended, therefore the collection comprises the works accomplished in different institutions. This could be the only location for the manuscripts of 1930–40s, as the Dissertation Collection of the Russian State Library was established after 1944. The authors argue that apart from their information value, the dissertations make the valuable source on the history of national science and society, demonstrate communications between academic organizations and continuity of scholar schools, and are of great memorial value. The mission of libraries is to preserve the scholar legacy of this country and to support accessibility of information on dissertations through e-catalogs and digitizing full texts of the Soviet-era theses.
Perancangan User interface Aplikasi CIRLIB (Cirebon Library) Berbasis Android pada Perpustakaan Kota Cirebon
Authors: Yusuf Maulana , Sari Dian Permata
Published: January 2023

Perpustakaan Kota Cirebon merupakan perpustakaan daerah yang digunakan sebagai wujud pelayanan kepada pemustaka dan masyarakat khususnya yang dinaungi oleh dinas perpustakaan dan kearsipan kota cirebon. Sistem pelayanan di perpustakaan kota cirebon yang dilakukan saat ini masih berjalan manual untuk berkaitan penyebaran informasi dan fasilitas layanan yang diberikan kepada masyarakat Kota Cirebon, hal inilah yang masih dirasa kurang efisien. Tujuan dari penelitian ini yaitu melakukan perancangan Aplikasi CIRLIB (Cirebon Library) berbasis Android untuk Perpustakaan Kota Cirebon. Perancangan User interface aplikasi ini dilakukan dengan pengumpulan data dan metode pengembangan sistem yang berfokus pada pembuatan Prototype. Metode yang pengembangan yang digunakan yaitu Software Development Ligfe Cycle (SDLC) dengan jenis prototype, dengan alasan metode ini tepat tepat dan mudah untuk di aplikasikan sesuai dengan jenis penelitian yang dilakukan. Penelitian ini dijadikan sebagai pengembangan penyelenggaraan perpustakaan di Kota Cirebon yang lebih efektif dan efisien. Adapun User interface CIRLIB (Cirebon Library) yang dibuat terdapat layanan informasi penting perpustakaan, layanan peminjaman buku, layanan baca di tempat, buku elektronik serta edukasi.
Şərqi slavyan dillərindəki Türk mənşəli sözlərdə baş verən leksik- semantik yeniləşmə
Authors: Tekeli Minahanım Nuriyeva
Published: January 2023

Məqalədə Rus ədəbi-bədii dil materiallarının verdiyi çox zəngin faktlar əsasında Şərqi slavyan dillərinin lüğət tərkibində mövzud olan türkizmlərdə baş verən məna diferensiallaşması prosesi geniş şəkildə tədqiq olunur. Göstərilir ki, çox hallarda mənbə dillərdən yalnız özünün bir mənası ilə rus dilinə daxil olmuş söz sonradan o yeni mühitdə özünün semantik çevikliyini və zənginliyini qazanır. Bununla da müstəqil leksik vahid kimi keçdiyi dilin lüğət tərkibinin semantikasını məzmunca xeyli zənginləşdirmiş olmuşdur. Diaxronik aspektdə işlənmiş bu məqalədə məna dəyişmələrinin obyektiv və subyektiv səbəbləri müəyyənləşdirilir, Rus ədəbi-bədii dil materiallarının verdiyi dil faktları üzrə türkizmlərin semantik inkişafı izlənilir, semantik inkişaf qanunauyğunluqları açıqlanır.
Metinle çeviri metinlerinin karşılaştırılarak incelenmesi
Authors: Mecidova Hayale
Published: January 2023

Çeviri çok eski bir geçmişe sahip bir bilimdir. Çeviri sırasında dildeki herhangi bir metin başka bir dile çevrilir ve sonuç olarak önceki dildeki fikir karşısındaki kişiye anlatılmaya çalışılır. Çevrilecek metin veya dile «kaynak metin» veya «kaynak dil», çevrilen ve türetilen metne «hedef metin» veya «hedef dil» denir. Çeviriler ağırlıklı olarak yazılı ve sözlü olarak yapılır. Yazılı şekilde çeviren kişiye “mütercim”, sözlü olarak çeviren kişiye “tercüman” veya “çevirmen” denir. Çeviri, genellikle, çeviriyi orijinal metne mümkün olduğunca benzer kılmak amacıyla bir fikrin bir dilden aynı içeriğe sahip başka bir dile aktarılmasıdır. Ancak dillerin doğası, kültürel farklılıklar ve bilimsel terimlerin yaygınlığı tam bir çeviriye izin vermemektedir. Çeviri tarihi Türk kültürünü geçmemiştir. Tercümenin ilk örneklerine Selçuklu devletinde ve ondan önce yaşamış Türk boylarında rastlamak mümkündür. 8. yüzyılda başlayıp 11. yüzyılda zirveye ulaşan İslam dünyasında tercüme ve bilimsel buluşlar alanı 12. yüzyıldan itibaren zayıflamış ve 18. yüzyıla kadar sürmüştür. Altı yüz yıllık bu durgunluk döneminde, Fatih Sultan Mehmet ve Kanuni Sultan Süleyman tarafından kurulan medreseler, öğrencilere felsefe, tıp ve diğer bilim dallarında çeşitli bilgiler vermiş, Arapça ve Farsça öğretmiş, bu dillerde edebiyat tercümeleri yapmış ve yayınlanmış ders kitaplarından yararlanılmıştır. Çeviri süreci dünyanın en kültürel olaylarından biri olarak kabul edilebilir. Çeviri işi ilk bakışta kolay gibi görünse de çeviri alanı gerçekten çok zor ve sorumluluk isteyen bir iştir. Ayrıca çevirmene de birçok görev yükler: Edebi metin çevirisinde çevirmen her şeyden önce eserin tüm güzelliğini, bütünlüğünü, ahengini ve etkisini sürdürebilmelidir. Çevirmen, yazarın ait olduğu kişilerin tarihi, coğrafyası, etnografyası, düşünce tarzı, gelenekleri ve özellikleri hakkında derin bir bilgiye sahip olmalıdır. Ayrıca çeviriyi oluştururken okuyucunun beğenisini de dikkate almalıdır. Edebi çeviride dil bilgisinin, özellikle çevirmenin her iki dilin sadece edebi biçimini değil, aynı zamanda konuşma biçimini, lehçelerini ve hatta argosunu bilmesi önemli koşullardan biridir.Çevirinin dili, çevirinin kaynak metin seviyesine yakınlık derecesi, çevirideki biçimlerin dil özelliklerinin korunması vb. tüm bu yönleriyle birlikte eserin genel sanatsal özellikleri korunmalıdır. Çevirmen önce çevrilecek esere hakim olmalı, sonra çeviriyi düşünmelidir. Çeviribilim çok ilgili ve ilginç bir dilbilim alanıdır. Azerbaycan ve Türkiye arasındaki dostluk gelenekleri eski tarihimize kadar uzanır. Dolayısıyla Azerbaycanlı ve Türklerin tarihi kökleri aynı olduğu için etimolojimiz ve geleneklerimiz de aynıdır. Hem Azerbaycanlıları hem de Türkleri Oğuz dil grubuna aittir. Azerbaycanlılar ve Türkler, tarihsel gelişim içinde birçok imparatorluk kurmuşlar ve diğer imparatorluğun çöküşüne neden olmuşlardır. Bu yüzden devletler arasındaki ilişkilerin giderek gelişmesi, hem sözlü hem de yazılı olarak her iki dilden tercüme edilecek malzemelerin sayısında şu zamana kadar artışa yol açmıştır.
Mətndaxili semantik proqressiya
Authors: Rüstəmli Aygün
Published: January 2023

Mətn bir linqvistik vahid kimi fikrin bitkinliyini bildirən mürəkkəb sintaktik bütövlükdür. Bütöv dedikdə, onun müxtəlif sayda komponentlərdən, onu təşkil edən cümlələrdən ibarət olması nəzərdə tutulur. Mətnin komponentləri sayılan cümlələr öz düzülüşü ilə həm ümumi mətn semantikasına, həm də strukturuna xidmət etməlidir. Mətnin öz kommunikativ funksiyasını yerinə yetirməsi üçün onu təşkil edən komponentlərin arasında qarşılıqlı bağlılığın olması mütləqdir. Çünki nisbi bitkinlik bildirən cümlələr mətn çərçivəsinə daxil olduqda digər cümlələrlə qarşılıqlı əlaqə yaradaraq ümumi bir mətn semantikasına, makrotemaya, eyni zamanda mikrotemaya qulluq edir. Komponentlər arasındakı bu əlaqə tiplərini araşdıraraq onları iki cür təsnif etmək olar: cümlələr arasında koheziya əlaqəsi və koherensiya əlaqəsi. Digər bir dillə desək məna və struktur əlaqə. Mətnin sintaktik strukturu və ya forması koheziya əlaqəsi kimi, semantik bağlılığı isə koheziya vasitələri ilə gerçəkləşən koherent əlaqə kimi müəyyənləşdirilir.
Mətndə bir-birini izləyən cümlələr arasında məntiqi-semantik əlaqə vasitəsilə ortaya çıxan, daxili mətn bağlılığını təmin edən koherensiya əlaqələri dilçilikdə semantik proqressiya kimi də tanınır. Bu termini ilk dəfə N.R.Wolf (2001/2002) irəli sürmüşdür.
Mann/Thompson (1986, 77-80) semantik proqressiyanı tədqiq edərək onun əsas növləri haqqında müddəalarını işləyib hazırlamışlar. Dilçilərin araşdırmalarına görə semantik proqressiyada koherensiyanın ifadə olunması üçün bir sıra qeyri-dil elementləri vacibdir. Tədqiqatda bağlayıcı vasitələrlə müəyyən edilən cümlələr arasındakı koherensiya əlaqələri və yaxud semantik proqressiya təsnif olunur.
About the life and creativity of Hajimolla Mahammad Nakhchivani, a great representative of the XIX century
Authors: İbrahimov Sebuhi
Published: January 2023

The article studies the life and work of Haji Molla Mahammad Nakhchivani, who is important for the study of manuscripts about Nakhchivan in the late 19th and early 20th centuries, which are still unknown to the scientific community. Thus, the structure, philological-textological analysis and palaeographic features of his works “Sahabad-Dumu”, “Kashkulun-Nur”, “Mazahir al-Anwar”, “Gurratul-Absar”, “Durratul-Abrar” were widely studied and certain scientific conclusions have been reached. Based on the research, it was determined how rich and comprehensive the creative activity of H.M Nakhchivani is. Also, along with the structural analysis of these works, which are a valuable product of his intense creative work, it was determined that their palaeographic features are even more scientific for the modern period. Purposeful research on the life and work of prominent scientists formed by the Nakhchivan environment in the late nineteenth and early twentieth centuries shows that authors with truly rich knowledge and skills beme indelible figures in history. The works of Nasreddin Tusi, Ekmeleddin Nakhchivani, Najmaddin Nakhchivani, Hindushah Nakhchivani, Nematullah Nakhchivani, Mahammadali Nakhchivani, Huseyn Javid, Mirza Jalil, Mahammad Taghi Sidgi, Mammad Said Ordubadi and others, who made remarkable efforts in enlightening of Azerbaijani people, could find their worthy place. The works of such well-known personalities have found their rightful place. Any work written by them was included in the list of pearls of human culture and has been serving mankind for centuries. These valuable sources of philosophical, literary, artistic, scientific, historical and logical ideas created by our thinkers save their value by passing down from generation to generation as our national treasure. One of such thinkers is Haji Molla Mahammad Nakhchivani, who was born in Nakhchivan in the late 19th and early 20th centuries and received material and spiritual nourishment from this land.
Clustering Analysis of Tweets About COVID-19 Using the K-Means Algorithm
Authors: Andi Andi , Juliandy Carles , David David
Published: January 2023

One of the trending topics in 2020 to 2022 is tweets about Coronavirus Disease 2019 (COVID-19). A large number of tweets regarding COVID-19 that have appeared have been mixed and not grouped properly, making it difficult for Twitter users to read and sort them based on the information they want. One solution that can be applied to overcome the problems described is through clustering of tweets information about COVID-19. In this study, researchers used quantitative research with the K-Means method, which is one of the clustering methods used in grouping data. The data used in this study is a dataset taken from Kaggle, namely Omicron-Covid-19 Variant Tweets, and also taken through a scraping process with Bright Data with a total of 4,103 datasets. The results showed that determining the best cluster using the Elbow method on the dataset produced empirical evidence that the best cluster was k = 5. The results of grouping tweets regarding COVID-19 using the K-Means Clustering method with k = 5 resulted in the largest number of cluster members being cluster 4 with 1,185 tweets, the second largest was cluster 1 with 1,047 tweets, the third largest was cluster 2 with 757 tweets, the fourth largest was cluster 3 as many as 744 tweets, and the smallest number of cluster members is cluster 5 as many as 370 tweets.
Atividade antibacteriana da solução aquosa bruta de flores de Brugmansia suaveolens
Authors: Brito Gabriel Rodrigues , Lima Matheus Botelho de , Maciel Gabriela Cardoso , Santos Mateus Silva
Published: January 2023

O uso indiscriminado de antibióticos resulta no aparecimento de bactérias super resistentes e que acarretam grandes problemas para a saúde pública. Portanto, novos compostos com propriedades antibacterianas são pesquisados para uma possível via de tratamento. A Brugmansia suaveolens, planta com propriedades psicoativas, é dotada de compostos químicos como os alcaloides, cumarinas, flavonoides, esteroides e hidrocarbonetos e que podem apresentar atividade antimicrobiana. Portanto, o presente estudo teve como objetivo verificar a atividade antibacteriana da solução aquosa bruta das flores desse vegetal. Foi realizado um estudo experimental, onde foi necessária a preparação da solução aquosa bruta das flores de Brugmansia suaveolens, seguida dos procedimentos para avaliação da atividade antibacteriana e posterior análise dos resultados obtidos. Percebeu-se a ação antibacteriana na espécie Staphylococcus aureus, apresentando halo inibitório de 25 mm em solução de 1000mg/ml e 23 mm em 500mg/ml. Por fim, nota-se a atividade antimicrobiana do vegetal em Staphylococcus aureus, no entanto são necessários mais estudos para total compreensão do potencial antimicrobiano da planta.
A cooperação entre fatores genéticos e epigenéticos na patogênese da Doença de Alzheimer
Authors: Nunes Gustavo Henrich Pereira , Lima Maria Fernanda Londe de , Orsolin Priscila Capelari
Published: January 2023

O envelhecimento é um resultado inevitável da vida, caracterizado pelo declínio progressivo da função dos tecidos, órgãos e elevação do risco de mortalidade. Juntamente com o acréscimo da população idosa, observado nos últimos anos, verifica-se aumento na prevalência de doenças neurodegenerativas, como a Doença de Alzheimer (DA). O presente estudo consiste em uma revisão integrativa da literatura com o intuito de identificar a influência de fatores genéticos e epigenéticos na patogênese da DA. A busca foi realizada durante os meses de setembro, outubro e novembro de 2022, considerando-se estudos publicados no período compreendido entre 2014 e 2022, nas seguintes bases de dados: BVS, PubMed MEDLINE, SCIELO, Google Scholar e EbscoHost. Atualmente, é muito claro que todas as características de um indivíduo não são determinadas apenas pelo DNA, mas pelo ambiente, estresse, estilo de vida e nutrição que desempenham papel vital na determinação da resposta de um organismo. Nesse sentido, mecanismos epigenéticos envolvem modificações estruturais e bioquímicas na cromatina, sem alterações na sequência de DNA, que desconfiguram o padrão de expressão de genes, afetando vários processos fisiológicos e patológicos. Logo, esse desequilíbrio na homeostase dos mecanismos epigenéticos são a base da expressão anormal de genes relacionados à plasticidade sináptica e à memória, áreas notadamente alteradas nas manifestações iniciais da DA. Dada a natureza reversível dos mecanismos epigenéticos, essas vias fornecem caminhos promissores para a terapêutica contra o declínio cognitivo e o melhor prognósticos para a doença.
Perfil clínico e epidemiológico dos pacientes com glaucoma atendidos em uma clínica na cidade de Imperatriz-MA
Authors: Acker Bruna Bressan , Penna Eduardo Martins , Nascimento Gustavo Bezerra , Sousa João Vitor Batista Corrêa , Branco Neto José Ribamar Carvalho , Lucena Maylla Rodrigues
Published: January 2023

O glaucoma é um dano ao nervo óptico, associado a um aumento da Pressão Intraocular (PIO) com referência entre 10 e 21 mmHg, tendo como principal desfecho, a cegueira. O objetivo de pesquisa é conhecer o perfil clínico e epidemiológico dos pacientes com glaucoma atendidos em uma clínica na cidade de Imperatriz – MA. Estudo de caráter descritivo, retrospectivo, com abordagem quantitativa. Foram estudados prontuários de atendimentos para verificar o índice da taxa de pacientes diagnosticados com glaucoma. Os dados foram adquiridos de um banco de dados (prontuários), de pacientes atendidos em junho de 2020 a junho de 2022, em serviço de pronto atendimento numa clínica particular, no período de agosto e setembro de 2022. A partir da análise de todos os indivíduos atendidos nesse período do estudo, foram selecionados apenas aqueles com diagnóstico de glaucoma com idade acima dos 40 anos, de ambos os sexos, tempo de diagnóstico e PIO. A população deste estudo tem média de idade de 70 a 79 anos e o sexo feminino prevaleceu. A principal causa da baixa visão encontrada foi o glaucoma sem tratamento ou tratamento inadequado. Pouco se sabe sobre os processos fisiopatológicos do glaucoma e acredita-se que a sua definição ainda está inacabada. Sugere-se novas pesquisas sobre a prevalência de glaucoma na cidade de Imperatriz. Os resultados do estudo são consistentes com a literatura pré-existente. O diagnóstico de um número potencialmente grande de doentes com glaucoma é uma tarefa muito complexa em termos de logística e impacto socioeconômico.
Avaliação do nível de incômodo da população de Itabira/MG à poluição atmosférica
Authors: Matos Carolina Aguiar de , Freitas Ana Carolina Vasques , Silva Athos Moises Lopes
Published: January 2023

A exposição à poluição atmosférica gera efeitos negativos à saúde humana, afetando a qualidade de vida e bem estar da população. Assim, este estudo teve por objetivo avaliar o nível de incômodo causado pela poluição atmosférica (principalmente por material particulado) à população de Itabira/MG, de modo a identificar o nível de conhecimento sobre o assunto, associado às características socioeconômicas, e as percepções acerca dos riscos à saúde. Para isso, foi realizada uma pesquisa de opinião com amostra da população no período de 29 de agosto a 31 de outubro de 2022 e investigou-se a relação entre o nível de incômodo com as características socioeconômicas, tais como, faixa etária, sexo, nível de escolaridade e local de residência, além de outros indicadores como mudanças no estilo de vida e problemas de saúde. As respostas foram comparadas com os dados medidos da qualidade do ar nas estações de monitoramento mais próximas do bairro de residência dos participantes. Posteriormente, foi realizada uma análise de correlação cruzada considerando todos os parâmetros avaliados e, por fim, empregou-se um modelo de regressão múltipla pelo método stepwise, permanecendo, ao final, apenas os preditores mais significativos (ao nível de 95%). Os principais fatores que determinaram o nível de incômodo da população foram: faixa etária, renda familiar, percepção da qualidade do ar no local de residência, presença de poeira e opacidade no ar, a frequência de limpeza da casa para a retirada da poeira, a realização de mudanças no estilo de vida e se o indivíduo é ou não fumante.
Ação antibacteriana do óleo essencial de Origanum vulgare: uma revisão de literatura
Authors: Queiroz Letícia da Silva , Alves Even Herlany Pereira , Santos Airton Lucas Sousa dos , Nascimento Hélio Mateus Silva , Araujo Paloma Maria de Sousa , Guimarães Ana Clara de Moura , Brito Vanessa dos Santos
Published: January 2023

Objetivo: Avaliar a possível utilização do óleo essencial de Origanum vulgare como uma opção de antibiótico no combate a bactérias de importância clínica resistentes a antibióticos. Metodologia: Trata-se de uma revisão de literatura onde foi realizada uma busca nos bancos de dados Google Academic, PUBMED e LILACS usando recorte temporal de 2012 a 2022, com os descritores "óleo essencial"; "Origanum vulgare"; "antibacteriano" e “antibiótico”. Resultados: Foram inclusos na revisão 10 estudos que avaliaram a relação entre o óleo essencial de Origanum vulgare e bactérias de importância clínica resistentes a antibióticos.  Discussão: O óleo essencial de Origanum vulgare (orégano) possui inúmeras ações biológicas descritas, das quais se destaca a atividade antimicrobiana. Essa atividade é atribuída, principalmente, ao seu componente majoritário carvacrol, que possui reconhecida atividade bactericida, além dos constituintes γ-terpineno e p-cimeno, que podem apresentar ação sinérgica com constituintes do óleo. O óleo terá como principal alvo de ataque a membrana celular, sendo sua eficácia dependente de vários fatores, como o local de colheita, parte da planta utilizada e forma de extração do óleo. Além disso, em alguns estudos, o óleo essencial de orégano obteve maior eficácia contra alguns patógenos em comparação ao antibiótico. Conclusão: O estudo realizado sugere que óleo essencial de orégano é eficaz no combate a bactérias de importância clínica, podendo ser estudado como uma opção ao combate de bactérias resistentes com pouca ou nenhuma opção de tratamento.