bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPETITIVIDADE E EVOLUÇÃO DA BOVINOCULTURA DE CORTE NO ESTADO DA BAHIA: UM ESTUDO BASEADO EM RECURSOS ESTRATÉGICOS
Authors: Pedreira Adriana Calmon de Brito , Monteiro Augusto de Oliveira
Published: February 2019

Este trabalho apresenta um estudo da competitividade e desempenho da bovinocultura de corte no Estado da Bahia com base na Resources Based View – RBV. Analisa as

características gerais do setor, as possibilidades de inovação nos contextos tecnológico, or
45 ANOS DE PENSAMENTO DE CELSO FURTADO SOBRE O DESENVOLVIMENTO DO NORDESTE (1959-2004)
Authors: Santos Nivalter Aires
Published: February 2019

Objetiva-se com esse trabalho fazer um balanço do pensamento de Celso Furtado sobre os problemas da região Nordeste e a questão do desenvolvimento, a partir de seus escritos entre 1959 e 2004. A orientação metodológica utilizada é o materialismo histórico
FURTADO X PELÁEZ: UMA SISTEMATIZAÇÃO DO DEBATE HISTORIOGRÁFICO
Authors: Gonzalez Nathalia Nascimento , Salomão Ivan Colangelo
Published: February 2019

Artigo sistematiza a controvérsia historiográfica sobre as origens da industrialização brasileira a partir do debate seminal entre Celso Furtado e Carlos Peláez. Para tanto, expõese a interpretação do primeiro autor, vulgarmente conhecida como “teoria dos
PLANEJAMENTO REGIONAL E PARTICIPAÇÃO SOCIAL: A EXPERIÊNCIA DO PLANO PLURIANUAL DA BAHIA (2007-2014)
Authors: Carvalho Simone Maria Lima de
Published: February 2019

Este artigo tem como objetivo discutir as principais estratégias adotadas pelo governo estadual, no período de 2007 a 2014, voltadas para a implementação do planejamento regional participativo, particularmente na elaboração dos Planos Plurianuais, com foc
A INFLUÊNCIA DA ECONOMIA CAFEEIRA NO PROCESSO DE INDUSTRIALIZAÇÃO DO BRASIL NA REPÚBLICA VELHA
Authors: Almeida Giovana Goretti Feijó de , Engel Vonia
Published: February 2019

Este artigo trata da reflexão sobre a lógica econômica brasileira na República Velha, a partir da produção cafeeira e suas implicações na industrialização brasileira. A importância de entender este período é em função da dependência da exportação de um ún
O RIO SÃO FRANCISCO E O DESENVOLVIMENTO ECONÔMICO DE MUNICÍPIOS MINEIROS LOCALIZADOS EM SUA BACIA
Authors: Araújo Diego Nizatto Oliveira , Souza Elvanio Costa de
Published: February 2019

A teoria dos polos de crescimento destaca o papel das atividades motrizes no desenvolvimento regional. Diante disso, este estudo procurou identificar os setores econômicos motrizes de alguns municípios mineiros localizados na bacia hidrográfica do rio São
AGROINDÚSTRIAS FAMILIARES NO SUL DO BRASIL: O TERRITÓRIO NA PERSPECTIVA DO DESENVOLVIMENTO
Authors: Karnopp Erica , Vogt Olgário Paulo , Bernardy Rógis Juarez , Etges Virginia Elisabeta
Published: February 2019

Neste artigo analisa-se o conceito de território na perspectiva do desenvolvimento de agroindústrias familiares no sul do Brasil. Como objeto empírico de análise elegeu-se as
agroindústrias familiares localizadas nas regiões do Vale do Rio Pardo, no Esta
ARRANJO PRODUTIVO LOCAL (APL): A EXPERIÊNCIA NO TERRITÓRIO DO SISAL NA BAHIA
Authors: Silva Filipe Prado Macedo da , Ortega Antonio César , Botelho Marisa dos Reis Azevedo
Published: February 2019

Este artigo tem como objeto de estudo o Arranjo Produtivo Local (APL) do Sisal, na Bahia. O APL do Sisal é uma aglomeração agroindustrial, constituída por uma extensa rede de agentes econômicos, políticos e sociais, que participam da cadeia produtiva do s
A EXPANSÃO NUCLEOELÉTRICA BRASILEIRA EM DEBATE
Authors: Cabral Anya
Published: February 2019

Evidencia-se a importância para o Brasil da indústria nucleoelétrica, assim como das condições para sua expansão quando o país é assediado por interesses internacionais. Descrevem-se as propostas para reembolso dos investimentos e transferências de custos
A FORMAÇÃO DO CAPITAL HUMANO E O DESENVOLVIMENTO DA BAHIA NO SÉCULO XX
Authors: Castro Helder , Spinola Noelio
Published: February 2019

Este artigo procura analisar a formação do capital humano do Estado da Bahia no século XX, a partir das contribuições teóricas das áreas dedicadas ao tema, considerando a
qualidade da mão de obra atuante em alguns dos principais agentes econômicos do est
DIFERENÇAS SALARIAIS E DISCRIMINAÇÃO POR GÊNERO E COR NA REGIÃO SUDESTE DO BRASIL
Authors: Bacchi Matheus Demambre , Maia Katy , Souza Solange de Cassia Inforzato de , Gomes Magno Rogerio , Catelan Davi Winder , Fonseca Maylisson Rodrigo
Published: February 2019

A região Sudeste é a mais populosa do país e a detentora da maior mão de obra. No entanto, seu mercado de trabalho possui divergências salariais nas quais as teorias do capital humano, da segmentação e da discriminação procuram elucidar. Nesse contexto, o
REDE URBANA DO ESTADO DA BAHIA: O CASO DE VITÓRIA DA CONQUISTA (BA)
Authors: Porto Leonardo Rodrigues , Santana Júnior Gildásio , Nascimento Humberto Miranda
Published: February 2019

Este artigo tem por objetivo discutir a relação exercida pela cidade de Vitória da Conquista (BA) com as demais cidades de sua área de influência, destacando-se o seu papel na
consolidação da rede urbana no interior do estado da Bahia. Para tanto, analis
BRASIL: MIGRAÇÃO INTER-REGIONAL E INTRA-REGIONAL DE RETORNO (1986/91, 1995/00 E 2005/10)
Authors: Silva João Gomes da , Nunes Erivelton de Sousa , Queiroz Silvana Nunes de
Published: February 2019

A ideia proposta neste estudo, é analisar a dinâmica migratória inter-regional e intra-regional de retorno no Brasil, nos quinquênios de 1986/1991, 1995/2000 e 2005/2010, identificando tendências e inflexões no cenário migratório recente. Usa-se os microd
DESENVOLVIMENTO ECONÔMICO E CAPITAL HUMANO: TEORIAS, CRÍTICAS E ANÁLISE DO CASO BRASILEIRO
Authors: Fonseca Edna Silva
Published: February 2019

As divergências e críticas em torno da Teoria do Capital Humano são pertinentes e ao mesmo tempo provocadoras, ao questionarem a capacidade dos investimentos em educação e saúde responderem aos ganhos privados em termos salariais, e a existência do elo en
PERSPECTIVAS DA REDUÇÃO DA POBREZA PELO TURISMO: PROPOSTA METODOLÓGICA PARA A ANÁLISE DO PROJETO DE 65 DESTINOS INDUTORES DO DESENVOLVIMENTO TURÍSTICO REGIONAL EM MINAS GERAIS (2007 / 2010)
Authors: Malta Guilherme Augusto Pereira , Faria Diomira Maria Cicci Pinto
Published: February 2019

A pesquisa tem por interesse analisar o elo que relaciona o turismo como promotor do desenvolvimento econômico e sua suposta capacidade de contribuir para a redução da pobreza. Toma-se como ponto de partida a política nacional,o Programa de Regionalização
EVOLUÇÃO DA DENSIDADE INDUSTRIAL NOS ESTADOS DO SUDESTE BRASILEIRO (2000/2010): VIVENCIAMOS UM FENÔMENO DE DESINDUSTRIALIZAÇÃO?
Authors: Manhães Vinícius Toledo , Rosendo Roberto Cezar
Published: February 2019

Este trabalho teve por objetivo investigar a ocorrência de um suposto processo de desindustrialização no Brasil, tomando por base os estados da região mais industrializada do país, a região Sudeste. É importante ressaltar que a maior parte dos estudos já
CENÁRIO DO TEATRO BAIANO
Authors: Spinola Noelio Dantaslé , Marinho Isabel Cristina Alves
Published: February 2019

Este texto, propõe-se delinear um quadro da construção do teatro baiano. Narra a sua trajetória, as políticas culturais que conduziram aos seus períodos de apogeu e de sombra,
partindo do século XVI seu marco fundador, até os dias atuais, quando abalado
COMUNICAÇÃO DA FORMAÇÃO DO CAPITAL HUMANO: ESTUDO COMPARATIVO DE RELATÓRIOSANUAIS DE GRANDES AGENTES ECONÔMICOS
Authors: Andrade Marta Cardoso de , Castro Hélder Uzêda
Published: February 2019

Este artigo visa estudar como é feita a comunicação, aos stakeholders, acerca da formação continuada do capital humano dos agentes econômico. Isso resulta da responsabilidade social destes agentes, a qual faz parte do atual e almejado conceito de sustenta
O EMPREGO NA INDÚSTRIA BRASILEIRA DE ALIMENTOS: DISTRIBUIÇÃO REGIONAL E TAMANHO DAS EMPRESAS
Authors: Leonardi Alex , Waquil Paulo Dabdab
Published: February 2019

Diante de um cenário que se inicia a partir dos processos de globalização e integração econômica, o Brasil se torna ator ainda mais importante no que diz respeito à produção e
comercialização de alimentos. Com isso, a indústria de alimentos precisa ser a
PERSPECTIVAS PARA O ETANOL BRASILEIRO FRENTE À EVOLUÇÃO DA TECNOLOGIA DOS MOTORES
Authors: Gonçalves Daniel Bertoli
Published: February 2019

Desde a invenção do automóvel, um grande debate se instaurou em torno da tecnologia de seus motores e dos combustíveis a serem empregados. Recentemente, o enrijecimento das legislações ambientais e a perspectiva de alta nos preços do petróleo, aliados ao
IDENTIFICAÇÃO DOS SETORES-CHAVE DOS TERRITÓRIOS DE DESENVOLVIMENTO DE MINAS GERAIS EM 2008
Authors: Gonçalves Caio César Soares
Published: February 2019

Sob a perspectiva de produção de informações que fomente políticas públicas de desenvolvimento regional, o presente artigo visa identificar os setores-chave dos territórios de desenvolvimento do estado de Minas Gerais através de técnicas de identificação
AS INDICAÇÕES GEOGRÁFICAS (IGS) COMO ESTRATÉGIA DE DESENVOLVIMENTO TERRITORIAL: DESAFIOS E POTENCIALIDADES NO DISTRITO DE MARAGOGIPINHO, ARATUÍPE, BA
Authors: Caldas Alcides dos Santos , Araújo Cristiano Cassiano de , Coury Rafael de Lira Mansur
Published: February 2019

O artigo em questão objetiva descrever e analisar a produção do artesanato no distrito de Maragogipinho, município de Aratuípe/BA, visando à solicitação de registro ao Instituto
Nacional de Propriedade Industrial (INPI) de uma Indicação Geográfica (IG) p
A TEORIA TRADICIONAL DO BEM-ESTAR: DA ORIGEM ÀS CRÍTICAS
Authors: Giacomelli Giana Silva
Published: February 2019

A teoria tradicional do bem-estar surgiu com força no início do século XX e até hoje exerce influência na análise da eficiência na promoção do bem-estar dos indivíduos. No entanto, faz-se necessário ultrapassar a barreira da utilidade e atingir a avaliaçã
HUBUNGAN VISUS DENGAN RISIKO JATUH PADA LANSIA DI KELURAHAN BACIRO YOGYAKARTA
Authors: Rigenastiti Amadea , Widagdo The Maria Meiwati , Suryanto Yanti Ivana
Published: February 2019

Background: The aging process causes changes of physiological and psychosocial functions. The percentage of older people population in Yogyakarta Province in 2015 was 13,49%, the highest in Indonesia. The increased number of older people is followed by the increased number of problems in older people. One of the most common problems of older people is falls. Risk of falls consists of intrinsic and extrinsic factors. Visual acuity is a part of the intrinsic factor of risk of falls in the older people.

Objective: To find out the correlation between visual acuity and the risk of falls of older people in Baciro Village Yogyakarta.

Methods: The research method was observational-analytic with cross sectional design. Researchers took samples in Baciro Village Yogyakarta. The inclusion criteria was people aged ≥60 years old. The exclusion criteria were older people who were illiterate and had neuromotor limitations in lower extremity.The data was collected by checking the visual acuity of the older people with Snellen chart. Falls Efficacy Scale International (FES-I) questionnaire was used to determine the risk of falling.

Results: Ninety-seven older people participated in this research.The results of bivariate analysis used Spearman correlation test showed that there was no correlation between the better eye visual acuity and the risk of falls in the older people (FES-I) (r = 0.190 and p = 0.063) and there was a significant correlation between the worse eye visual acuity and the risk of falls in the older people (r = 0.240 and p = 0.018).

Conclution: 1) There is no correlation between the better eye visual acuity and the risk of falls in the older people. 2) There is a correlation between the worse eye visual acuity and the risk of falls in the older people.

Keywords: Visual acuity, Risk of Falls, FES-I
The impact of good corporate governance and Sharia compliance on the profitability of Indonesia’s Sharia banks
Authors: Fitriana Hamsyi Nur
Published: February 2019

This article aimed to observe the influence of Good Corporate Governance (GCG) and Sharia compliance on the profitability of Sharia banks in Indonesia. This study uses secondary data obtained from 2012 until 2016 with nine samples of Indonesia’s Sharia banks according to purposive sampling criteria. Data are processed by using data panel regression analysis. The independent variables used are the composite value of GCG, which is the result of the self-assessment of the Sharia bank, as well as the proxy of Sharia compliance, namely Islamic Income Ratio (IsIR) and Profit Sharing Ratio (PSR), while the dependent variable used is profitability with a Return on Equity (ROE) as the proxy. The results showed that GCG and PSR variables have negative values indicating that there is no influence of GCG and PSR on ROE, while the variable of IsIR influences ROE value. This study provides benefits in presenting useful information to assess the compliance of Islamic banks based on Sharia principles.
Mitochondria Associated Membranes (MAMs): Emerging Drug Targets for Diabetes
Authors: Sasi U.S. Swapna , Ganapathy Sindhu , Palayyan Salin Raj , Gopal Raghu K.
Published: February 2019

MAMs, the physical association between the Endoplasmic Reticulum (ER) and mitochondria
are, functional domains performing a significant role in the maintenance of cellular homeostasis.
It is evolving as an important signaling center that coordinates nutrient and hormonal signaling for
the proper regulation of hepatic insulin action and glucose homeostasis. Moreover, MAMs can be
considered as hot spots for the transmission of stress signals from ER to mitochondria. The altered
interaction between ER and mitochondria results in the amendment of several insulin-sensitive tissues,
revealing the role of MAMs in glucose homeostasis. The development of mitochondrial dysfunction,
ER stress, altered lipid and Ca2+ homeostasis are typically co-related with insulin resistance
and β cell dysfunction. But little facts are known about the role played by these stresses in the development
of metabolic disorders. In this review, we highlight the mechanisms involved in maintaining
the contact site with new avenues of investigations for the development of novel preventive and
therapeutic targets for T2DM.
Prediction of Drug Combinations with a Network Embedding Method
Authors: Wang Tianyun , Chen Lei , Zhao Xian
Published: February 2019

Aim and Objective:

There are several diseases having a complicated mechanism. For such
complicated diseases, a single drug cannot treat them very well because these diseases always
involve several targets and single targeted drugs cannot modulate these targets simultaneously. Drug
combination is an effective way to treat such diseases. However, determination of effective drug
combinations is time- and cost-consuming via traditional methods. It is urgent to build quick and
cheap methods in this regard. Designing effective computational methods incorporating advanced
computational techniques to predict drug combinations is an alternative and feasible way.

Method:

In this study, we proposed a novel network embedding method, which can extract
topological features of each drug combination from a drug network that was constructed using
chemical-chemical interaction information retrieved from STITCH. These topological features were
combined with individual features of drug combination reported in one previous study. Several
advanced computational methods were employed to construct an effective prediction model, such as
synthetic minority oversampling technique (SMOTE) that was used to tackle imbalanced dataset,
minimum redundancy maximum relevance (mRMR) and incremental feature selection (IFS)
methods that were adopted to analyze features and extract optimal features for building an optimal
support machine vector (SVM) classifier.

Results and Conclusion:

The constructed optimal SVM classifier yielded an MCC of 0.806, which
is superior to the classifier only using individual features with or without SMOTE. The performance
of the classifier can be improved by combining the topological features and essential features of a
drug combination.
Antitumoral and Anticholinesterasic Activities of the Seven Species from Rubiaceae
Authors: Volobuff Carla R.F. , Junior Pedro C.O. , dos Santos Sidney M. , Pereira Zefa V. , Ferreira Diego C. , Cardoso Claudia A.L. , Ruiz Ana L.T.G. , Foglio Mary A. , de Carvalho João E. , Formagio Anelise S.N.
Published: February 2019

Background:

The genus Psychotria and Palicourea are reported as a source of alkaloids and
iridoids, which exhibit biological activities. This study aimed to evaluate antiproliferative and anticholinesterase
activities and quantification of the alkaloids of seven species among the genus found in
Mato Grosso do Sul region in Brazil.

Methods:

Concentrations of alkaloids were measured spectrophotometrically. The extracts were submitted
to antiproliferative activity against ten cell lines. The anticholinesterase activity of the extracts
was developed using brain structures of male Wistar rats: cerebral cortex, hippocampus, hypothalamus
and striatum by the Ellman method.

Results:

Alkaloids from Psychotria and Palicourea species were quantified which showed values of
47.6 to 21.9 µg/g. Regarding the antiproliferative potential, Palicourea crocea demonstrated selectivity
against the 786-0 cell line (GI50: 22.87 µg/mL). Psychotria leiocarpa inhibited cell growth against
OVCAR-3 (GI50: 3.28 µg/mL), K-562 (GI50: 5.26 µg/mL), HaCaT (GI50: 27.20 µg/mL), PC-3 (GI50:
34.92 µg/mL), MCF-7 (GI50: 35.80 µg/mL) and P. capillacea showed activity against OVCAR-3 (GI50:
2.33 µg/ml) and U251 (GI50: 16.66 µg/ml). The effect of acetylcholinesterase inhibition was more effective
in the hippocampus, demonstrating inhibition for Paliourea crocea, Psychotria deflexa,
P. brachybotrya and P. leiocarpa of 70%, 57%, 50% and 40%, respectively, followed by
P. poeppigiana and P. capillacea, inhibiting 21%, compared to the control.

Conclusion:

Herein, the present work showed for the first time, anticholinesterasic and antiproliferative
activities of extracts of Palicourea and Psychotria seem to be mainly associated with the levels of
alkaloids in the leaves of these species.
The Bleeding Risk in Antithrombotic Therapies: A Narrative Review
Authors: Alatri Adriano , Mazzolai Lucia
Published: February 2019

Bleeding represents the most important complication of antithrombotic treatment, including
anticoagulant and antiplatelet therapies. A number of scores were proposed to evaluate the risk of bleeding
both for anticoagulant and antiplatelet treatment. In the last decade, 5 bleeding risk scores were published
for use in atrial fibrillation patients, and 3 scores for patients receiving anticoagulants for venous
thromboembolism therapy or prophylaxis. In addition, 3 scores were recently developed to assess inhospital
or short-term bleeding risk in patients receiving antiplatelet therapy after Acute Coronary Syndrome
(ACS) and Percutaneous Coronary Intervention (PCI). Furthermore, 3 additional scores have
focused on long-term bleeding in outpatients receiving dual antiplatelet therapy after PCI. The aim of
this review is to consider the evidence on bleeding scores.
Synthesis, Characterization, and Dynamic Behavior of Well-defined Dithiomaleimide-functionalized Maltodextrins
Authors: Hidalgo Francisco J. , Lorentz Nathan A.P. , Luu TinTin B. , Tran Jonathan D. , Wickremasinghe Praveen D. , Martini Olnita , Iovine Peter M. , Schellinger Joan G.
Published: February 2019

:

Maltodextrins have an increasing number of biomedical and industrial applications due to their attractive physicochemical properties such as biodegradability and biocompatibility. Herein, we describe the development of a synthetic pathway and characterization of thiol-responsive maltodextrin conjugates with dithiomaleimide linkages. 19F NMR studies were also conducted to demonstrate the exchange dynamics of the dithiomaleimide-functionalized sugar end groups.
Real-World Comprehensive Disease Management of Patients With Idiopathic Pulmonary Fibrosis
Authors: Mason Wendi , McLaughlin Sally , Dedopoulos Sophy , Mahoney Erin , Meadows Tonja , Stauffer John L. , Lancaster Lisa H.
Published: February 2019

Idiopathic pulmonary fibrosis (IPF) is a debilitating, progressive, and fatal fibrotic lung disease with a poor prognosis. Antifibrotic therapy slows but does not halt disease progression. Patient education and management needs change during disease progression. Management is complicated by comorbidities, adverse events associated with antifibrotic therapy, and difficulties with long-term oxygen therapy and pulmonary rehabilitation. Treating IPF requires coordination between physicians and nurses in community and interstitial lung disease center settings. This review provides guidance for the healthcare professional who manages the essential aspects of care in IPF from diagnosis, through disease progression, and to the end of life.
Electrochemical Determination of Norepinephrine at Poly (p-aminobenzenesulfonic Acid) Modified Sensor
Authors: Yağcı Şevket Zişan , Savan Ebru Kuyumcu , Erdoğdu Gamze
Published: February 2019

Objective:

In this study, it was aimed to prepare an electrochemical sensor capable of assigning Norepinephrine in the presence of an interference such as ascorbic acid.

Methods:

A sensitive modified sensor was prepared by electrodeposition of p-aminobenzenesulfonic acid (p-ABSA) to the glassy carbon electrode by cyclic voltammetry. The electrooxidation of Norepinephrine was accomplished by cyclic and differential pulse voltammetry.

Results:

The current values were enhanced and the peak potentials of Norepinephrine and ascorbic acid were separated at the sensor compared to the bare electrode. There was linearity between the oxidation current and concentration of Norepinephrine ranging from 0.5 to 99.8 μM in phosphate buffer solution at pH 7.0. The limit of detection was 10.0 nM and the sensitivity was 0.455 μA/μM.

Conclusion:

The determination of Norepinephrine was successfully performed in real samples such as blood serum and urine at the poly (p-ABSA) sensor. To the best of our knowledge, this is the first study to detect Norepinephrine in the presence of ascorbic acid at poly (p-ABSA) modified sensor in the literature.
Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview
Authors: Manickam Balamurugan , Sreedharan Rajesh , Chidambaram Kumarappan
Published: February 2019

:

Transdermal drug delivery systems (TDDS) are one of the fascinating unconventional drug delivery systems offering plentiful advantages of which patient compliance is of paramount importance. However, as a matter of fact, the transdermal delivery of drug molecules is absolutely a tedious job which is precisely influenced by a number of factors including penetration barrier properties of the skin, drug characteristics formulation allied issues, etc. Over the years, innumerable tremendous efforts have been made in transporting the drugs through the skin into the systemic circulation by noteworthy tactics. This paper discusses such revolutionary formulation based techniques that have been endeavored in achieving the enhanced skin permeation of drugs, controlled release, and safety.
Cancer Therapy Based on Smart Drug Delivery with Advanced Nanoparticles
Authors: Kong Xiangqi , Liu Yi , Huang Xueyan , Huang Shuai , Gao Feng , Rong Pengfei , Zhang Shengwang , Zhang Kexiang , Zeng Wenbin
Published: February 2019

Background:

Cancer, as one of the most dangerous disease, causes millions of deaths every year. The
main reason is the absence of an effective and thorough treatment. Drug delivery systems have significantly
reduced the side-effect of chemotherapy. Combined with nanotechnology, smart drug delivery systems including
many different nanoparticles can reduce the side-effect of chemotherapy better than traditional drug delivery
systems.

Methods:

In this article, we will describe in detail the different kinds of nanoparticles and their mechanisms
emphasizing the triggering factors in drug delivery. Besides, the application of smart drug delivery systems in
imaging will be introduced.

Results:

Combined with nanotechnology, smart drug delivery systems including many different nanoparticles
can reduce the side-effect of chemotherapy better than traditional drug delivery systems.

Conclusion:

Despite considerable progress in nanoparticle research over the past decade, such as smart drug
delivery systems for the treatment of cancer, molecular imaging probes and the like. The range of nanoparticles
used in multifunction systems for imaging and drug delivery continues to grow and we expect this dilatation to
continue. But to make nanoparticles truly a series of clinical products to complement and replace current tools,
constant exploration efforts and time are required. Overall, the future looks really bright.
Grape Seed Proanthocyanidins Protect N2a Cells against Ischemic Injury via Endoplasmic Reticulum Stress and Mitochondrial-associated Pathways
Authors: Fu Kun , Chen Liqiang , Miao Lifeng , Guo Yan , Zhang Wei , Bai Yunan
Published: February 2019

Background/Objective:

Grape seed proanthocyanidins (GSPs) are a group of polyphenolic
bioflavonoids, which possess a variety of biological functions and pharmacological properties. We
studied the neuroprotective effects of GSP against oxygen-glucose deprivation/reoxygenation
(OGD/R) injury and the potential mechanisms in mouse neuroblastoma N2a cells.

Methods:

OGD/R was conducted in N2a cells. Cell viability was evaluated by CCK-8 and LDH release
assay. Apoptosis was assessed by TUNEL staining and flow cytometry. Protein levels of cleaved
caspase-3, Bax and Bcl-2 were detected by Western blotting. CHOP, GRP78 and caspase-12 mRNA
levels were assessed by real-time PCR. JC-1 dying was used to detect mitochondrial membrane potential.
ROS levels, activities of endogenous antioxidant enzymes and ATP production were examined to
evaluate mitochondrial function.

Results:

GSP increased cell viability after OGD/R injury in a dose-dependent manner. Furthermore,
GSP inhibited cell apoptosis, reduced the mRNA levels of CHOP, GRP78 and caspase-12 (ER stressassociated
genes), restored mitochondrial membrane potential and ATP generation, improved activities
of endogenous anti-oxidant ability (T-AOC, GXH-Px, and SOD), and decreased ROS level.

Conclusion:

Our findings suggest that GSP can protect N2a cells from OGD/R insult. The mechanism
of anti-apoptotic effects of GSP may involve attenuating ER stress and mitochondrial dysfunction.
GABA and 5-HT Receptor Mediated Anxiolytic Effect of Essential Oil of Ferula sumbul Hook. Roots
Authors: Batra Sonali , Kumar Ashwani , Sharma Anupam
Published: February 2019

Background:

Ferula sumbul Hook. (Umbelliferae) roots have been traditionally used as sedative in nervous disorders.

Objective:

The present study identifies the components of essential oil of F. sumbul roots (EOFS) using GC-MS analysis and further evaluates mechanism-based anxiolytic potential of oil.

Materials and Methods:

EOFS was extracted using Clevenger apparatus, and was screened for anxiolytic activity using an elevated plus maze model. A battery of models was subsequently used to confirm the anxiolytic potential of EOFS. Further, benzodiazepine (BZD) receptor antagonist flumazenil and pentylenetetrazole (PTZ) were used for investigating the possible involvement of GABA receptors.

Results:

GC-MS analysis of EOFS revealed the presence of 32 components comprising triterpenoids and their derivatives. The oil exhibited significant anxiolytic activity at 50 μl/kg in various models like the elevated plus maze, light/dark, mirror chamber, open-field and mCPP-induced anxiety. The observation that anxiolytic effect of EOFS was completely blocked by benzodiazepine (BZD) receptor antagonist flumazenil, and partially by pentylenetetrazole, clearly demonstrates that anxiolytic activity of the oil is mediated mainly through BZD site on GABA receptors. Further, a significant reversal of mCPP induced anxiety by EOFS strongly indicates the possible involvement of 5-HT receptors in mediating anxiolytic activity of the oil.

Conclusion:

Results of the present study clearly demonstrates the anxiolytic potential of EOFS and, thus, validates the traditional relevance of the plant. This is the first report not only on multi-model based antianxiety activity of EOFS but also on the possible antianxiety mechanism of the oil.
Chemical Constituents of Luculia pinceana in Vietnam and Evaluation of their Biological Activity
Authors: Giang Phan Minh , Huyen Le Thi , Dau Nguyen Van , Anh Duong Hong , Viet Pham Hung
Published: February 2019

Background:

In the flora of China and Vietnam, Luculia pinceana Hook of the family
Rubiaceae is described as a medicinal plant. Prior chemical studies of L. pinceana in China isolated
iridois, glycosides of cincholic acid, and kaempferol glycosides from the stem, however, have not
been conducted with L. pinceana in Vietnam.

Methods:

The stem of L. pinceana was extracted with a mixture of 90%EtOH–H2O at room temperature
and the extract was further fractionated by using liquid-liquid extraction and repeated column-
chromatographic techniques. Spectroscopic data (IR, MS, 1D- and 2D-NMR) were used to determine
structures of isolated compounds.

Results:

Thirteen compounds were isolated and structurally determined. Oleanolic acid (2),
scopoletin (3), cleomiscosin A (4), (E)-mappianine E (5a), (Z)-mappianine E (5b), vanillic acid (6),
2-hydroxyacetophenone-4-O-β-D-glucopyranoside (7), sweroside (10), and 4-methoxyacetophenone-
2-O-β-D-glucopyranoside (11) were isolated for the first time from L. pinceana. Compounds
6, 10, 11, loganin (8), 7-ketologanin (9) were not active (IC50 > 300 µg/ml), whereas 7
showed a weak activity (IC50 268.35 µg/ml) in the DPPH (1,1-diphenylpicrazyl) radical scavenging
assay. A mixture of 5a/5b was cytotoxic against the human cancer cell line HepG2 (IC50 100.57
µg/ml) in the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

Conclusion:

L. pinceana in Vietnam was investigated for the first time. We isolated compounds of
varied biosynthetic origins including monoterpene indole, iridoid, coumarin, coumaro-lignoid, phytosterol,
oleanane triterpenoid, phenolic acid, and acetophenone. Nine of the thirteen compounds are
newly isolated from L. pinceana. The study determined weak scavenging activity of acetophenone
(7) in the DPPH-scavenging assay and weak cytotoxicity of a mixture of two monoterpene indoles
(5a and 5b) against HepG2 cell.
CdSe Quantum Dots Induce Cellular Differentiation in HL-60 Cells
Authors: Saran Amit D. , Bellare Jayesh R.
Published: February 2019

Background:

CdSe QDs, synthesized using a green micro-emulsion method, have been evaluated for their potential in inducing HL-60 differentiation by employing various biochemical assays and as cellular imaging agents.

Methods:

CdSe QDs have been found to effectively induce differentiation with lower rate of cell apoptosis as compared with the positive control (DMSO).

Results:

Our results exhibit effective induction of HL-60 differentiation by CdSe QDs implicating their therapeutic role in cancerous cells in addition to their usual application as cell-imaging agents.

Conclusion:

Our studies report that the chemo-preventive properties of CdSe exhibit great potential and further tailored-synthesis and cell-differen-tiations studies have a promising future in the preventive treatment of HL60 cancerous tissue.
Formation of Corrosion Resistant Hard Coating of Litao3 by Anodizing in Molten Lino3
Authors: Hu Likun , Yuan Sicheng , Xie Panping , Xu Dengfeng , Peng Zhi , Xie Axi , Zheng Feng
Published: February 2019

Background:

Lithium tantalate (LiTaO3) thin film was synthesized and in situ coated on
tantalum substrate via anodic oxidation.

Methods:

The effects of temperature, voltage and time on composition, morphology and hardness of
film were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Vickers
hardness, respectively.

Results:

Our results showed that surface hardness of all coated samples has been increased compared
with that of pure tantalum. The value of hardness was found to gradually increase with temperature,
voltage and reaction time of the coating process. Selected specimens, after coating, were immersed
into 10 wt% NaOH solution at 50oC for 96h to explore their anti-corrosion performance. Immersing
results indicated that LiTaO3 coated samples have a smaller mass loss and corrosion rate compared
to those of pure Ta substrate. Pure tantalum sample and those coated by LiTaO3 thin film were further
examined by electrochemical methods including open-circuit potential (OCP), potentiodynamic
polarization curves and electrochemical impedance spectra (EIS).

Conclusion:

We have found that samples coated with LiTaO3 thin film exhibit higher potentials and
lower corrosion current densities than those of pure tantalum substrate, according to the results and
analysis of OCP curves and potentiodynamic polarization curves. Upon anodic oxidation, samples
display higher polarization resistance with higher resistance to corrosion.
Values of aesthetic and religiosity towards tourism attraction
Authors: Regeg I Made , Triguna Ida Bagus Gde Yudha , Winaja I Wayan
Published: February 2019

The results of this study were values of aesthetic and religiosity ​​at the location have implications for tourist visits, economy, arts, culture, education, and the dynamics of the people in Karangasem Regency, namely (1) Implications for tourist visits: increased visits during the last two years have increased 5.8%, (2) Implications for the economy: there have been an increase in community economics, (3) Implications for art culture: there has been an increase in cultural arts creativity, 4) Implications for education: there was educational creativity increasing religious spiritual strength, self-control, personality, intelligence, noble character, and skills needed for himself, society, nation and country (5) Implications for the dynamics of the ummah, namely: (1) the increase of the people to pray and the harmony between humans and the God and their manifestations, humans and humans, and their environment.
The Effect of Robot Attentional Behaviors on User Perceptions and Behaviors in a Simulated Health Care Interaction: Randomized Controlled Trial (Preprint)
Authors: Johanson Deborah L , Ahn Ho Seok , MacDonald Bruce A , Ahn Byeong Kyu , Lim JongYoon , Hwang Euijun , Sutherland Craig J , Broadbent Elizabeth
Published: February 2019

BACKGROUND

For robots to be effectively used in health applications, they need to display appropriate social behaviors. A fundamental requirement in all social interactions is the ability to engage, maintain, and demonstrate attention. Attentional behaviors include leaning forward, self-disclosure, and changes in voice pitch.

OBJECTIVE

This study aimed to examine the effect of robot attentional behaviors on user perceptions and behaviors in a simulated health care interaction.

METHODS

A parallel randomized controlled trial with a 1:1:1 allocation ration was conducted. We randomized participants to 1 of 4 experimental conditions before engaging in a scripted face-to-face interaction with a fully automated medical receptionist robot. Experimental conditions included a self-disclosure condition, voice pitch change condition, forward lean condition, and neutral condition. Participants completed paper-based postinteraction measures relating to engagement, perceived robot attention, and perceived robot empathy. We video recorded interactions and coded for participant attentional behaviors.

RESULTS

A total of 181 participants were recruited from the University of Auckland. Participants who interacted with the robot in the forward lean and self-disclosure conditions found the robot to be significantly more stimulating than those who interacted with the robot in the voice pitch or neutral conditions (P=.03). Participants in the forward lean, self-disclosure, and neutral conditions found the robot to be significantly more interesting than those in the voice pitch condition (P<.001). Participants in the forward lean and self-disclosure conditions spent significantly more time looking at the robot than participants in the neutral condition (P<.001). Significantly, more participants in the self-disclosure condition laughed during the interaction (P=.01), whereas significantly more participants in the forward lean condition leant toward the robot during the interaction (P<.001).

CONCLUSIONS

The use of self-disclosure and forward lean by a health care robot can increase human engagement and attentional behaviors. Voice pitch changes did not increase attention or engagement. The small effects with regard to participant perceptions are potentially because of the limitations in self-report measures or a lack of comparison for most participants who had never interacted with a robot before. Further research could explore the use of self-disclosure and forward lean using a within-subjects design and in real health care settings.
ICD10Net: An Artificial Intelligence Algorithm with Medical Background Conducts ICD-10-CM Coding Task with Outstanding Performance (Preprint)
Authors: Lin Chin , Lou Yu-Sheng , Lee Chia-Cheng , Hsu Chia-Jung , Wu Ding-Chung , Wang Mei-Chuen , Fang Wen-Hui
Published: February 2019

BACKGROUND

An artificial intelligence-based algorithm has shown a powerful ability for coding the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) in discharge notes. However, its performance still requires improvement compared with human experts. The major disadvantage of the previous algorithm is its lack of understanding medical terminologies.

OBJECTIVE

We propose some methods based on human-learning process and conduct a series of experiments to validate their improvements.

METHODS

We compared two data sources for training the word-embedding model: English Wikipedia and PubMed journal abstracts. Moreover, the fixed, changeable, and double-channel embedding tables were used to test their performance. Some additional tricks were also applied to improve accuracy. We used these methods to identify the three-chapter-level ICD-10-CM diagnosis codes in a set of discharge notes. Subsequently, 94,483-labeled discharge notes from June 1, 2015 to June 30, 2017 were used from the Tri-Service General Hospital in Taipei, Taiwan. To evaluate performance, 24,762 discharge notes from July 1, 2017 to December 31, 2017, from the same hospital were used. Moreover, 74,324 additional discharge notes collected from other seven hospitals were also tested. The F-measure is the major global measure of effectiveness.

RESULTS

In understanding medical terminologies, the PubMed-embedding model (Pearson correlation = 0.60/0.57) shows a better performance compared with the Wikipedia-embedding model (Pearson correlation = 0.35/0.31). In the accuracy of ICD-10-CM coding, the changeable model both used the PubMed- and Wikipedia-embedding model has the highest testing mean F-measure (0.7311 and 0.6639 in Tri-Service General Hospital and other seven hospitals, respectively). Moreover, a proposed method called a hybrid sampling method, an augmentation trick to avoid algorithms identifying negative terms, was found to additionally improve the model performance.

CONCLUSIONS

The proposed model architecture and training method is named as ICD10Net, which is the first expert level model practically applied to daily work. This model can also be applied in unstructured information extraction from free-text medical writing. We have developed a web app to demonstrate our work (https://linchin.ndmctsgh.edu.tw/app/ICD10/).
Coffee Economy in Late Colonial Netherlands East Indies: Estates and Capital, 1890–1940
Authors: Pradadimara Dias
Published: February 2019

This paper provides an attempt to look at the coffee economy in late colonial Netherlands East Indies, by focusing on the private estates that produced coffee and on the capital-owning class who invested in these estates. Since mid-19th century there was an increasing accessibility for would-be planters to gain access to land, especially in Java and Sumatra. Attracted to the increasing, if volatile, the world price of the commodity, coffee-producing estates were established in great numbers across the archipelago, despite the threat of the coffee leaf rust plantdisease. Only the attraction to rubber planting and the economic crisis in the 1930s dampened the enthusiasm. At the same time, the individual planters and Indiesbased companies who controlled most of the coffee producing estates in the late 19th century were gradually replaced by incorporated companies both based in the Indies and in the Netherlands. The increasing flow of capital following the rubber boom in the early 20th century made the role of individual planters and Indiesbased companies declined further.
From A Colonial to A National Company: The Nationalization of Western Private Plantation in Indonesia
Authors: Wasino Wasino
Published: February 2019

This paper discusses the nationalization of Dutch-owned enterprises in post-colonial Indonesia in a process termed Indonesianisasi. It looks at the legal framework necessary for the transfer of assets. It also looks into the process of nationalization in some companies and the regulations created in order to create a semblance of due process.
The Relationship between Elementary Chemical Composition and Extraction Method for Protium strumosum Daly species Resin
Authors: Fontes Ricardo G. A. , Zuniga Rafael M. , Sampaio Paulo T. B. , Silva Claudia C.
Published: February 2019

The genus Protium Burm f., the most abundant of the Burseraceae family, has its primary center of diversity in the Amazon. Its main characteristic is the exudation of “Breu”, an aromatic resin collected directly from the trunk of the trees.

Stimulating pastes have been used to increase resin flow, such as 2-chloroethylphosphonic (Ethephon). It is important to evaluate variations in the composition of the resin extracted naturally and with the use of the stimulant, to guarantee the product quality. The inorganic analysis is also fundamental to verify the presence of compounds harmful to health.

A quali-quantitative elemental variation of the resin between the two extraction modes was proved by WD-XRF analysis. In 15 samples, Mg and F were only observed in those using Ethephon. In samples from the same tree, the qualitative difference is 54%, proving a discrepancy in the chemical composition of Breu, which can alter its properties.
Personal competencies of Spanish students pursuing different academic careers. Contributions and reflections from Positive Psychology
Authors: Orejudo Hernández Santos , Aparicio Moreno Lucía , Cano Escoriaza Jacobo
Published: February 2019

This investigation analyzes a sample of 332 Spanish teenagers following different academic careers and the relationship among four emergent cognitive concepts in positive psychology: dispositional optimism, hope, self-efficiency and the sense of coherence. The results indicate statistically significant differences between individuals who have pursued successful academic careers, regardless of the direction towards university or professional orientation, and those who have had unsuccessful academic backgrounds. Furthermore, there are interrelationships between all constructs considered, clearly defining a positive development profile in adolescents, which suggest further research and development of different human performance indicators to promote positive development in adolescents.
How does Positive Psychology research look in Latin America, Spain and Portugal?
Authors: Hernández Pozo María del Rocío , Salazar Piñeros Fabio Alexander
Published: February 2019

Editorial note
About the Subtle and the Manifest in the ATLG scale
Authors: Moral de la Rubia José , Valle de la O Adrian
Published: February 2019

The aims of this paper were to calculate internal consistency of the Attitude toward Lesbian and Gay Men (ATLG) scale, to determine its factor structure, and to verify the equivalence of the factor structure pattern by gender. An incidental sample of 452 undergraduate students was collected. Internal consistency of its 20 items was high (alpha = .94). It was defined a solution of three factors nested to one general factor: one factor related to an attitude of rejection toward lesbians (ATL), another factor related to an attitude of open rejection toward gay men (ATG-Open), and a third factor related to an attitude of subtle rejection toward gay men (ATG-Subtle). The three factors had high values of internal consistency (.91, .84, and .79, respectively). This factor model showed an adequate data fit (Chi-square/df = 2.38, RMSEA = .05, GFI = .91, and AGFI = .90), and resulted valid for men and women in the multigroup contrast (Chi-square/df = 1.80, RMSEA = .04, GFI = .87, and AGFI = .83). Nevertheless, the 20-item ATLG scale could be reduced to the 5 items composing the ATG-Subtle factor owing to the extremely strong weights that the general factor had on its three nested factors and the low risk of underestimation of the actual attitudinal rejection that this reduction conveys. It is recommended the use of the ATLG scale with its 20 items in Mexico, and its study in other Spanish-speaking countries.
Building an Academic Self Concept for Adolescents (ASCA)
Authors: Ordaz Villegas Gabriela , Acle Tomasini Guadalupe , Reyes Lagunes Isabel
Published: February 2019

Academic self-concept is the perception that a student has about his/her own academic abilities, constitutes one of the most relevant variables in the academic world, because of its influence on learning and cognitive functioning. Self-concept is a general assessment; nevertheless the current measurement instruments used for this construct are specific rather than general. Thus the purpose of this study was to construct and validate an academic self-concept scale with global dimensions, focused on teenager students. In its first stage, an open questions survey was designed to be applied with the intent of knowing the academic activities inside and outside the school. Afterwards, a closed questions survey was applied to a sampling consisting of 347 students ranging 14 to 18 years old from a public high school, east of México City. After obtaining the internal consistency and the items differentiation, a factorial analysis with orthogonal rotation was developed. The results grouped 16 items in 4 factors: self-regulation, general intellectual abilities, motivation and creativity. The scale shows 44.72% of a varying with a global Cronbach Alpha of .828. The present study contributes with an innovative scale with appropriate psychometric features, which globally assesses the academic self-concept.