bluuebunny/crossref_metadata_2025 huggingface dataset:
A Super-Wideband Antenna for THz wireless communication based on quadratic Bezier outline
Authors: Marouf Fatima Zahra , Ziani-Kerarti Djalal
Published: July 2022

This paper describes a new super wide band monopoly antenna for THz applications.. It has a Super-Wideband performance (3-16 THz) and up which present a fractional bandwidth greater than 135%. it has 2:1 VSWR with 10 dBi peak realized gain and flat group delay. These results satisfy the frequency and time-domain characteristics of the antenna. The radiator and antenna ground plan is based on quadratic Bezier outlines, which can be optimized with few controls’ points. The proposed antenna is designed on Rogers RT5880 substrate (εr=2.2) with a very compact size (42×32×1.6 µm 3). Therefore, this antenna can be used in THz wireless communication systems. such as T-WPAN, T-WBAN and T-WLAN. It can be employed as an elementary antenna in MIMO systems.
Partial recovery of the left DLPFC-right insula circuit with reduced carving in abstinent heroin users: a longitudinal study
Authors: Zhang Shan , Li Minpeng , Wang Shicong , Zhang Jun , Liu Jun , Yuan Kai
Published: July 2022

Background
Brain recovery phenomenon after long-term abstinence had been reported in substance use disorders. Yet, few longitudinal studies have been conducted to observe the potential recovery in heroin users, and little is known about the neural mechanism underlying the decreased craving after prolonged abstinence.
Methods
The 8-month longitudinal design was carried out for 29 heroin users and 30 healthy controls. By choosing the L_DLPFC activated by heroin cue as seeding region, the different brain connections patterns were compared between HCs and HUs by using Granger causality analysis (GCA) at baseline. Then paired t-test was employed to detect the potential recovery of L_DLPFC circuits after prolonged abstinence. Visual analog scale (VAS) and trail-making test-A (TMT-A) were adopted to investigate craving and cognitive control impairments, respectively. The neuroimaging changes were then correlated with the behavioral improvements. Similar analyses were applied for the mirrored right DLPFC to verify the lateralization hypothesis of the DLPFC in addiction.
Results
In the longitudinal study, enhanced GCA coefficients were observed in the L_DLPFC-R_insula circuit in heroin users after long-term abstinence, which were associated with craving score changes. At baseline, decreased GCA coefficients from left DLPFC to bilateral SMA and right putamen, together with the reduced GCA strength from bilateral OFC to left DLPFC were found between HUs and HCs.
Conclusion
Our findings extended the brain recovery phenomenon into heroin fields and suggested the increased regulation of the L_DLPFC over the insula after prolonged abstinence was important for craving inhibition.
Efficacy of a machine learning-based approach in predicting neurological prognosis of cervical spinal cord injury patients following urgent surgery
Authors: Shimizu Tomoaki , Suda Kota , Maki Satoshi , Koda Masao , Harmon Satoko Matsumoto , Komatsu Miki , Ota Masahiro , Ushirozako Hiroki , Minami Akio , Takahata Masahiko , Iwasaki Norimasa , Takahashi Hiroshi , Yamazaki Masashi
Published: July 2022

Prediction of the neurological prognosis of cervical spinal cord injury (CSCI) is useful for setting treatment goals. This study aimed to develop a machine learning (ML) model for predicting neurological outcomes of CSCI. We retrospectively analyzed 135 patients with CSCI who underwent surgery within 24 hours after injury. American Spinal Injury Association impairment scales (AIS; grades A to E) were analyzed 6 months after injury as primary outcome measures. A total of 33 features extracted from demographic variables, surgical factors, laboratory variables, neurological status, and radiological findings were analyzed. The multiclass ML model was created using Light GBM, XGBoost, and CatBoost. The accuracy, recall, precision, and F1 score were calculated for each classification model. We evaluated Shapley Additive Explanations (SHAP) values to determine the variables that contributed the most to the prediction models. Of the ML models used, CatBoost had the highest accuracy (0.807), recall (0.574), precision (0.808), and F1 score (0.622). AIS grade at admission, intramedullary hemorrhage, longitudinal extent of intramedullary T2 hyperintensity, total motor index score of the lower extremity, and HbA1c were identified as important features for the prediction model. The ML models successfully predicted neurological outcomes for five grades of AIS 6 months after injury.
Influence of Collision Angle Micro-deviation of Symmetric Nozzles on Collision Atomization Characteristics
Authors: Ma Yarui , Cui Jiwen , Tan Jiubin
Published: July 2022

The large-scale high-precision machining of the nozzles in the collision atomizer is quite difficult. The slight deviation of the nozzle inclination causes the collision angle to change doubly, which affects the collision position and the spatial distribution of the atomized droplets and reduces the combustion efficiency of the combustion chamber. In order to improve the atomization performance of the dual jet collision atomizer, this study firstly investigates the influence of the collision angle micro-deviation on the atomization characteristics based on the laser interference particle measurement technology (IPI). To jointly study the real-time characteristics of the internal flow and atomization field, a collision atomizer with transparent nozzles is independently designed, and the collision angle is controlled by a high-precision rotary stage. The cavitation phenomenon in the internal flow field is analyzed by simulation and experiment. The hydraulic parameters and atomization performance of the collision atomization field are measured and analyzed. The experimental results show that under the same injection pressure, the increase of the collision angle leads to the decrease of the Sauter Mean Diameter (SMD) and the increase of the atomization cone angle. Taking 60° as the benchmark, within the variation range of ± 5°, the collision angle deviation has little effect on the spatial distribution of atomized droplets.
An audit of documentation of surgical inpatient records, retrospective , descriptive study
Authors: Gasoma Elmuhtadi , Abdalla Islam , Afifi Mohammed
Published: July 2022

Background A medical record audit is a procedure that involves internal or external reviews of the procedures to determine which ones are being carried out correctly and which ones require improvement. Reviewing rules, procedures, and any other elements that have an impact on the efficacy and efficiency of thorough documentation in practice are included in this. Performing an audit of medical records is a preventative measure to identify potential errors that may give rise to investigations. For instance, these assessments can uncover unreported compliance issues that may have an impact on the quality of treatment provided to patients.Study design: Retrospective, descriptive study.Study area: Surgical ward at ribat university hospital .Sample size: A systematic random sample of the last four months' worth of inpatient medical records from a chosen ward was taken. There were 120 case sheets in the sample. The medical record section's discharge case files for the previous four months served as the primary source for the primary data collected. Quantitative methods were utilized to collect the data. Survey and observation were the methods used. 37 checkpoints on a structured checklist (an audit tool) were created.Results: The planned care was not prepared in accordance with the surgery department's usual protocol, and the records were not deemed to be accurate.Recommendation: Educating the clinical staff about the value of accurate form completion and hospital-wide uniformity in the maintenance of medical records, including admission and discharge summaries. The hospital should place a strong emphasis on rewarding the top-performing departments or units and teaching and training the accountable personnel to thoroughly document every patient. A regular audit of the documentation process is required.Conclusion: Medical records are legally required to include a complete, accurate account of every patient's specific care or interactions with hospital staff. In a hospital, medical records are a vital and crucial document. These documents are essential for arranging future hospital medical care as well as for legal concerns.
A pan-cancer analysis of the oncogenic role of protein regulator of cytokinesis 1(PRC1) in human tumors
Authors: Chen Xiaoxu , Hou Dingkun , Dong Shiqiang , Ai Xin , Qin Zheng , Li Hongzheng , Wang Haitao
Published: July 2022

Protein regulator of cytokinesis-1 (PRC1) belongs to the microtubule-associated proteins (MAPs) family, increasing evidence supports that epigenetic abnormalities PRC1 was related to multiple cancers in humans. However, pan-cancer studies of multiple human cancers are still lacking. PRC1 was overexpressed in many kinds of human tumor tissues, and the high expression of PRC1 was ralated to poor prognosis and clinical features. The results of gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway analyses of the PRC1 and its co-expressed genes showed that many gene terms related to cell circle, kinesins and, regulation of cytokinesis. PPI network analysis showed PRC1 have strong interactions with KIF4A, RACGAP1, KIF20A, KIF14, PLK1, KIF20B. Moreover, PRC1 methylation and copy number variation (CNV) were shown to be strongly linked with mRNA expression in most cancer types. Additionally, we also found that the expression level of PRC1 in multiple cancer types is correlated with tumor cell immune infiltration, TMB and MSI, providing a basis for further guiding tumor immunotherapy. PRC1 may serve as a biomarker for cancer progression and poor prognosis, providing a new way of thinking for cancer treatment.
Ontological modelling of creep void analysis data to automate machine learning training process
Authors: Zeb Akhtar , Mätäsniemi Teemu
Published: July 2022

This work focuses on the ontological representation of creep void analysis data to automate the training of the machine learning (ML) model detecting creep voids in scanning electron microscope images. Metallic high-temperature structures are subject to creep phenomenon that can lead to rupture and component failure when prolonged. ML models can be deployed to detect and obtain information about the density and location of creep voids using images as input data. However, due to the irregularities in the size and shape of creep voids and the associated uncertainty in ML models, the material engineer is required to inspect the detections and provide feedback on a regular basis. To automate the retraining of the ML model and to facilitate the close collaboration between the ML experts and the material engineers, domain ontologies providing common vocabularies can be utilized. We aligned the relevant concepts of the EMMO ontology, ML-Schema, and the PROV ontology to document creep void data for smooth information sharing and improving the quality of the ML detection process, hence resulting in better analysis and higher productivity compared to manual characterization. The SPARQL queries are used to gain valuable insights, such as the number and area of creep voids, condition of the metallic structure, and accuracy of the ML predictions.
Helicobacter pylori: a real stomach bug and Future treatment prospects
Authors: Baker Doha H. Abou , Abbas Heba S.
Published: July 2022

Recently, nanotechnology considered one of the most frontiers in scientific sector, which increasingly attracted researchers’ interest due to its variable and valuable applications in all areas. Synthesis of nanoparticles represents a promising era in therapeutical research that may lead to the development of new approaches in pharmaceutical studies. Selenium nanoparticles (SeNPs) share a status of high repute owing to their remarkable therapeutical potential. Biological synthesis of environment-friendly SeNPs using plant extracts has emerged as the beneficial alternative approach to chemical synthesis. In this regard, we have synthesized biogenic SeNPs (PG-SeNPs) using pomegranate peels (PP) aqueous extract as a stabilizing and reducing agent. The PG-SeNPs were characterized and evaluated for their anti-Helicobacter pylori (H.pylori) and anti-stomach cancer potential. Transmission electron microscopy (TEM) confirmed the formation of biogenic PG-SeNPs. The PG-SeNPs were efficacious against H.pylori. The PG-SeNPs at sub-MIC values showed dose-dependent inhibition of biofilm formation. The anti-stomach cancer ability of the PG-SeNPs was evaluated against SNU-16 stomach cancer cells. As evident from the MTT results, PG-SeNPs significantly reduced the cell viability in a dose-dependent manner. Briefly, the PG-SeNPs evolved with synergistically emerged attributes that were effective H. pylori; moreover, the PG-SeNPs and Se/Cu composite embodies intriguing anticancer potential against stomach cancer cells.
Characteristics of bacterial community during the pile fermentation of Pu-erh tea in a five-ton batch of Pu-erh tea commercial production process
Authors: Yang Rui-Juan , Zhang Wei , Wang Qiao-Mei , Peng Wen-Shu , Lv Jie , Yan Liang , Sheng Jun , Lu Jun
Published: July 2022

The purpose of this investigation was to study the bacterial community and the dominant bacterial species in the fermentation process of Pu-erh tea. Bacteria were isolated under different temperature, humidity and acidity conditions according to the actual pile-fermentation characteristics. The 16S rRNA gene analysis results revealed that these bacteria could be classified as 27 species. Polymerase chain reaction denaturing gradient gel electrophoresis (PCR-DGGE) profile showed that Klebsiella pneumoniae, Enterobacter turicensis, Lactobacillus plantarum, and Enterobacter aerogenes presented as dominant species. The number of these four dominant bacteria reached 108, 108, 105 and 107 copies/g dry tea, respectively, at the initial stage detected by real-time quantitative PCR (q-PCR), and all decreased during the process of pile fermentation. The knowledge will enable industrial selection, maintenance and growth of starter culture for high quality Pu-erh tea.
Influence of landscape and livestock management on dung beetle diversity in tropical cattle pastures
Authors: González-Gómez Lizbeth , González-Tokman Daniel , García Juan H. , Lira-Noriega Andrés , Escobar Federico
Published: July 2022

To achieve a balance between conservation and livestock production in the context of highly degraded tropical landscapes, we need a research approach that considers relationships among biodiversity, landscape structure, and farming practices. Given that dung beetles are sensitive to both landscape changes and local scale management practices, these insects are used as ecological indicators that provide information regarding the pasture’s health. We assessed the response of dung beetle diversity to livestock management practices and landscape structure in 22 cattle pastures from a regional relictual landscape dominated by productive land uses. Livestock management practices were the best predictors for species richness, Shannon diversity, and number of individuals. Macrocyclic lactone use was negatively related to species richness and number of individuals; high cattle densities increased Shannon diversity in the studied ranches. Patches of old-secondary forest cover had a positive significant relationship with every response variable and was the best predictor for biomass, but also contributed to maintaining high species richness in cattle pastures, suggesting that secondary forests provide favorable microclimatic conditions for dung beetles in highly degraded landscapes. This study provides evidence that conservation of old-secondary forests in highly modified landscapes and the rational use of macrocyclic lactones can be useful management tools to favor dung beetle diversity and the ecosystem services they provide, thus ensuring pasture health.
The Quality of Malaria Case Management in Different Transmission Settings in Tanzania Mainland, 2017–2018
Authors: Hussein Ally Kassim , Tarimo Donath , Reaves Erik J. , Chacky Frank , Abade Ahmed Mohamed , Mwalimu Charles Dismas , Mohamed Ally , Nasser Ahlam , Kishimba Rogath Saika
Published: July 2022

Background
Tanzania is currently undergoing an epidemiological transition for malaria transmission with some areas of the country having < 10% (hypoendemic) and other areas ≥ 10% malaria prevalence (mesoendemic). Hypoendemic areas on the continuum toward elimination require higher testing rates for fever cases and appropriate treatment. There is a lack of information about the quality of malaria case management in elimination settings in Tanzania mainland. This study examined the influence of endemicity on the quality of malaria case management at health facilities.
Methods
An analytical cross-sectional study was conducted among health facilities in Tanzania mainland. Data were collected by the National Malaria Control Program using an assessment tool to monitor the quality of malaria case management at facilities from September 2017 to December 2018. Using standard quality factors, mean scores from facilities in the different endemicity regions were compared by a Student’s t-test. Simple and multiple linear regression analyses were performed to determine the association between facility performance (score) and endemicity (mesoendemic vs. hypoendemic).
Results
Malaria case management data from 1713 health facilities (1425 public; 288 private), representing 21.3% of all facilities nationally, were available for analysis. Facilities located in mesoendemic regions scored higher compared to those in hypoendemic regions on the overall quality of services [difference in mean scores (d̄) = 2.52; (95% CI 1.12, 3.91)], site readiness [d̄ = 2.97; (95% CI 1.30, 4.61)], availability of malaria reference materials [ d̄ = 4.91; (95% CI 2.05, 7.76)], Health Management Information System tools [d̄ = 5.86; (95% CI 3.80, 7.92)] and patient satisfaction [d̄ = 6.61; (95% CI 3.75, 9.48)]. Facilities in hypoendemic regions scored lower than those in mesoendemic regions [β: -1.54; (95% CI -2.74, -0.53)]. Facilities in urban areas scored lower than those in rural areas [β: -1.56; (95% CI -2.76, -0.38)]. Facilities in regions with implementing partner support scored higher than those without [β: 7.92; (95% CI 6.26, 9.57)].
Conclusion
Health facilities located in malaria mesoendemic regions overall scored higher compared to those in hypoendemic regions. There is a need to target improvement efforts in the lower performing facilities regardless of endemicity setting.
Body mass index and paraspinal muscle on sagittal spino-pelvic alignment and balance in patients with degenerative kyphosis: a case-control study
Authors: Liang Yan , Xu Shuai , Zhu Zhenqi , Guo Chen , Liu Haiying
Published: July 2022

Objective To characterize the distribution of paraspinal muscle in degenerative kyphosis (DK) and identify the impact of body mass index (BMI) and paraspinal muscle on sagittal alignment and balance status.Summary of Background Data The relationship between sagittal alignment, BMI and paraspinal muscle in DK remains unidentified and the available methods for paraspinal muscle measurement are complex. It is assumed that the relationship between muscle and kyphotic severity can be characterized with a simplified procedure.Methods Degenerative thoracolumbar kyphosis (TLK) or loss of lumbar lordosis (LL) was defined as DK group (81 cases), and 60 volunteers composed control group well-matched to DK group in terms of age and gender. DK was evaluated by TLK and LL; paraspinal muscle was depicted by lumbar crossing indentation value (LCIV) on T2-MRI; sagittal balance for DK was evaluated by pelvic incidence (PI) and pelvic tilt (PT). For DK patients, normal-weight, overweight and obesity were defined based on BMI. For balance status, lumbo-pelvic balance (SB1) and imbalance (SIB1) depicted by PI-LL and pelvic balance (SB2) and retroversion (SIB2) expressed by PT were both defined.Results The mean LCIV (mLCIV) in DK group was smaller, and LCIV increased from T12-L1 to L4-L5 in DK group (P <0.01). In DK group, mLCIV in normal-weight subgroup was smaller than that in obesity subgroup (P <0.05). The mLCIV in DTLK only subgroup was larger compared to other 2 subgroups (P <0.05). In DK group, mLCIV was positively correlated with BMI and LL, and BMI and LL were influencing factors of mLCIV in DK group. The mLCIV was larger in SB1 group, while TLK and LCIV were predictors for PI-LL in DK patients. The mLCIV was also larger in SB2 group and LL was an independent predictor for PT in DK patients. Conclusions: LCIV is smaller in DK group while larger in sagittal balance status. LCIV, but not BMI, is correlated with sagittal alignment. This concept simplifies the primay diagnosis of DK group and plays a substantial role in maintaining the sagittal balance.
Treatment of developmental hip dysplasia under 24 months by modified anterior open reduction: A short-term follow-up study
Authors: Liu Xiping , Liu Kun
Published: July 2022

Background: Open reduction(OR) through an anterior approach for the treatment of developmental dysplasia of the hip (DDH) in children younger than 24 months of age is a popular method with proven high success rates . The aim of this study is to present the results of open reduction through a modified anterior approach. Methods: We retrospectively reviewed 60 hips of 45 patients with DDH under 24 months who underwent this modified anterior approach from June 2017 to February 2020. The surgical technique, operative time, intraoperative bloodloss and preoperative Tonnis grade and acetabular index (AI) were recorded in detail. In the latest follow up, the length of the scar, range of motion (ROM), the postoperative AI, centre-edge angle (CEA), Severin radiographic grade and avascular necrosis (AVN) of the femoral head were all assessed.Results: The average operation time was 25 ± 2.8 minutes in unilateral side and 45 ± 4.5 minutes in bilateral sides, the average intraoperative bloodloss was 10.0 ± 4.2 ml in unilateral side and 25.0 ± 1.3ml in bilateral sides. The mean AI was 35.03 ± 2.18°(range 29-45°) in the preoperative period and 20.68 ± 2.01°(range16-33°) at the final follow-up visit. The mean CEA at the final follow-up visit was 23.15 ± 2.05° (range18-32°). On the basis of the modified McKay classification for functional evaluation of hips, the postoperative excellent and good rate reached 96.6%. According to Severin radiological classification evaluation criteria, the postoperative excellent and good rate also reached 93.3%. Three of the hips that had been operated on showed type I signs of avascular necrosis(AVN) in X-ray. Four hips in three patients underwent secondary revision surgery. Conclusions: Open reduction through the modified anterior small incision approach was an encouraging and safe option for treating DDH patients younger than 24 months old who need an open reduction-only treatment, especially for patients with bilateral DDH. Bone procedures may be required for those patients with preoperative AI greater than 40° and(or) Tonnis grade IV.Level of evidence: IV, retrospective non-randomized study.
Robotic-Assisted Surgery in Pediatrics: What Is Evidence-Based? A Review of the Literature
Authors: Boscarelli Alessandro , Giglione Emanuela , Caputo Maria Rita , Guida Edoardo , Iaquinto Marianna , Scarpa Maria-Grazia , Olenik Damiana , Codrich Daniela , Schleef Jurgen
Published: July 2022

Aim of the study: This study examines evidence-based indications for robotic-assisted surgery (RAS) in the different fields of pediatric surgery.Methods: A systematic database search (MEDLINE, Scopus, Web of Science) was performed to identify articles covering any aspect of RAS in the pediatric population. Using Boolean operators AND/OR, all possible combinations of the following search terms were used: robotic surgery, pediatrics, neonatal surgery, thoracic surgery, abdominal surgery, urologic surgery, hepatobiliary surgery, and surgical oncology. The selection criteria were limited to the English language, pediatric patients (under 18 years of age), and articles published after 2010.Main Results: A total of 239 abstracts were reviewed. Of these, 10 published articles met the purposes of our study with a level of evidence I/II and therefore were analyzed. Notably, most of the articles included in this review reported evidence-based indications in urological surgery.Conclusions: According to this study, the exclusive indications for RAS in the pediatric population are pyeloplasty for ureteropelvic junction obstruction in older children and ureteral reimplantation according to the Lich-Gregoire technique in selected cases for the need to access the pelvis with a narrow anatomical and working space. All other indications for RAS in pediatric surgery are still under discussion to date, and cannot be supported by papers with a high level of evidence. However, RAS is certainly a promising technology. Further evidence is strongly encouraged in the future.
Characterization of Virgin, Recycled, and Oxygen-reduced Copper Powders Processed by the Plasma Spheroidization
Authors: Sehhat M. Hossein , Cullom Tristan , Newkirk Joseph W.
Published: July 2022

Copper powder in three different powder types were spheroidized using radio-frequency inductively coupled plasma (ICP) spheroidization process (TekSphero-15 system). The characterized powders include virgin powder as purchased from the powder manufacturer, powder used in electron beam powder bed fusion (EB-PBF) process, and reconditioned powder, which was used powder that underwent an oxygen-reduction treatment. The goal of spheroidizing these powder types was to evaluate the change in powder morphology, the possibility of enhancing the powder properties back to their as-received conditions, and assess oxygen reduction of the powder lots given their initial oxygen contents. Also, to investigate the impact of re-spheroidization on powder properties, the second round of spheroidization was performed on the already used-spheroidized powder. The impact of powder type on powder sphericity and particle size distribution was evaluated using the image analysis of scanning electron microscope (SEM) micrographs and laser diffraction, respectively. The spheroidized powder showed higher sphericity and more uniform particle size distribution overall. Depending on the powder collection bin, second round of spheroidization affected the powder sphericity differently. The possibility of deploying the plasma spheroidization process as an alternative oxygen-reduction technique was also investigated through tracking the powders’ oxygen content using inert gas fusion method before and after the spheroidization. The plasma spheroidized powder showed less oxygen content than the hydrogen-treated powder. The second round of spheroidization caused no change in oxygen content. The correlation between oxygen-reduction and created cracks was discussed and compared between plasma spheroidization and hydrogen-treatment. The plasma spheroidization process created a powder with higher sphericity, uniform particle size, and less oxygen content.
ANALYSIS OF MODERN MODELS OF EMPLOYEES MOTIVATION IN INTERNATIONAL COMPANIES IN THE CONTEXT OF CULTURAL FEATURES
Authors: Diakonova І. , Shcherbyna T. , Yurchenko A. , Sinyagovsky Yu.
Published: July 2022

Globalization and integration have had a profound impact on the development of business communities in different countries. Thus, cultural conflict is inevitable. However, this should not be a problem for international business and communication. A manager in an intercultural organization must understand the most important motivating factors and effectively use the most powerful ones in different contexts. Creating appropriate incentives for the employee is an essential part of human resource management in enterprises. They are designed to mobilize the enthusiasm and initiative of employees in different ways to complete tasks and achieve the goals of enterprises with high performance and quality. An effective incentive mechanism can increase employees' enthusiasm and stimulate their inner potential to make significant and continuous efforts to achieve the company's goals.
The study examines the impact of cultural differences on motivational factors in the context of human resource management. The authors analyzed the features of the American and Japanese human resource management styles. Based on a combination of Hofstede's 5-D model application to these countries and GWS surveys, they concluded that the model effectively identifies business culture characteristics.
The largest number of significant factors influencing employee motivation refers to those ones in Hofstede's model that scored the highest points. Therefore, it makes sense to use them as a basis for developing incentives and compilation of compensation packages. This approach gives only approximate estimates. To obtain the most relevant motivation model, the HR department needs to design additional questionnaires to identify the individual characteristics of employees in international companies.
MARKETING COMMUNICATIONS IN THE CONTEXT OF ENTREPRENEURIAL ACTIVITY: BIBLIOMETRIC ANALYSIS
Authors: Rosohata А. , Nesterenko V. , Khomenko L. , Kropyva V.
Published: July 2022

Interest in marketing communication tools in business is growing every year. At the same time, unlike big companies, entrepreneurs have small financial resources to promote their business. Therefore, low-budget and highly effective marketing communication tools are used first. The work aims to systematize scientific knowledge on marketing communications in business. The objectives of the work are to understand the content and characteristics of existing research on marketing communications in SMEs and to identify areas of research in recent years. In recent years, public interest in marketing communications, including digital communications, has been gradually growing. The number of scientific publications is growing even faster. Most of the works are devoted to the following aspects: promotion in social media, digital marketing, Web 2.0, creative consumers, communication strategies, Visible light communication. The most cited article (820 citations) is devoted to Word-of-mouth as an element of marketing communications. The article on Visible light communication (2013) has the highest average level of citations. The earliest highly acclaimed article was published in 1990 and focused on Communication strategies in marketing channels. Seven clusters related to performance, model, marketing, social media, social media marketing, Word-of-mouth, behavior were identified. Also among the research areas are the following: consumers, Facebook, strategies, loyalty, attitudes, advertising, information, adaptation, trust, and others. Studies have been on SMEs, analytics, big data, population, brand trust, millennials, celebrations, crown virus, investor segment, food marketing, Instagram, services, community, firm performance, segment, website, and others. This article may be helpful to practicing marketers and researchers in the study of marketing communication tools.
INTERNAL AUDIT AS AN EFFICIENT CORPORATE CONTROL TOOL UNDER THE CONDITIONS OF THE COVID-19 PANDEMIC
Authors: Zhukova T. , Baranova K. , Plikus I.
Published: July 2022

Under the conditions of the Covid-19 pandemic the classic functionality of internal audit is subject to review. It is necessary to change the usual activity trajectory, meet the dialogue with the company’s business administration on the issues of business running. The advisory function which allows to conduct an independent assessment as well as to insure the implementation of anti-crisis measures planned by the company’s business administration steps forward. The article analyses the interest of scholars in the research topic using Google Trends research tools and Google Ngram Viewer. The concept of internal audit in the system of corporate control is considered. The objectives of internal audit and their relationship for corporate control have been identified. The principles of optimal organization of the internal audit service of the enterprise are described. The necessity of an internal audit service existence as an effective tool of corporate control has been proved. The role of internal audit during the COVID-19 pandemic has been identified and the measures taken by internal auditors to respond to the challenges posed to the business by COVID-19 have been explored. Audit processes during the COVID-19 pandemic are described. The need to make changes to the plan in case of non-compliance of the plan with the most significant risks is stated. The trends of expected risks caused by the COVID-19 pandemic have been identified. The steps for risk identification and assessment are presented, in particular: risk identification; risks assessment and its analysis and risk response. The directions of internal audit activity during the COVID-19 pandemic are indicated. The recommendations of international experts on internal audit are analysed, the priority of internal audit areas is presented. The priority of the consulting function of internal audit is emphasised. The participation of the internal audit service in anti-crisis measures to overcome the consequences of the COVID-19 pandemic is proposed.
Cytological and Histopathological Correlation of Salivary Gland Tumours
Authors: Muthumani L , Muthuraman M , Mutharasi C Aruna
Published: July 2022

Background: Tumours of the salivary gland comprise 3-6% of all tumours of head and neck region. Fine Needle Aspiration Cytology (FNAC) is a widely recognized practical and non-expensive technique to differentiate between the benign and malignant lesions. The objectives of the study are, 1. To study the histopathology of benign and malignant tumours of salivary glands. 2.To correlate cytological and histopathological diagnosis of salivary gland tumours.Method: FNAC was done under strict aseptic precautions with 18–22-gauge needles with 10cc syringe after getting informed and written consent. Slides were fixed in alcohol and stained with Haematoxylin and Eosin. The fixed surgical specimens were processed and sections of 5-micron thickness were cut and stained with Haematoxylin and EosinResult: Out of the 50 cases studied 39(78%) were benign and 11(22%) were malignant. In the present study out of 41 cases reported as benign in cytology, 38 were proved to be benign and three cases turned into malignant in histopathology. The sensitivity, specificity and accuracy of cytological diagnosis to diagnose benign lesions are 92.8%, 100% and 94% respectively. In the present study out of eight cases reported as malignant tumour, all were later proved in histopathology as malignant. The sensitivity, specificity and diagnostic accuracy of cytology to diagnose malignant tumours are 75.4%, 100% and 94% respectively.Conclusion: Thus FNAC is the safe, reliable, quick, convenient and accurate method of diagnosis and should be considered as one of the first line investigations in the evaluation of salivary gland lesions.
Mullerian Adenosarcoma of Uterus and Cervix- A Report of Four Cases with Review of Literature
Authors: Ebenezer Evelyn Elizabeth , Shah Saloni Naresh , Geetha N
Published: July 2022

Uterine sarcomas are rare female genital tract malignancies. Mullerian adenosarcoma is a rare biphasic malignant mesenchymal tumor comprising of a benign glandular and malignant (usually low grade) stromal component, both of which are integral and neoplastic constituents of the tumor.[1] This tumor represents less than 8% of uterine sarcomas. About 200 cases have been reported in the literature so far [2] of which 22 case were from India. Adenosarcomas are usually low grade. Sarcomatous overgrowth is defined as the presence of sarcomatous component is more than 25% of the tumor volume. High grade morphology was termed adenosarcoma with sarcomatous overgrowth (i.e, presence of pure sarcoma , without epithelial component comprising 25% of the tumor).The features of high grade sarcomatous overgrowth include severe nuclear pleomorphism, prominent nucleoli , increased mitotic activity and necrosis[2].    Herein, we present four cases of adenosarcoma of the uterine corpus and cervix, discuss their clinico-pathological findings in detail and add a note on the recent and evolving concepts
Osseocartilaginous metaplasia in the Endometrium: A Rare Reversible Cause of Secondary Infertility
Authors: Senapati Swagatika , Mahawar Shruti , Pani Krushna Chandra
Published: July 2022

Osteo-cartilaginous metaplasia in endometrium is an infrequent finding and usually presents with secondary infertility. This is a benign entity and usually associated with a previous history of abortion. It can be treated successfully with hysteroscopy and henceforth reverting infertility. Awareness of this entity is important in order to avoid overdiagnosis of mixed Mullerian tumor of the endometrium followed by hysterectomy. Herein, we present one such case of a 28-year-old female who presented with secondary infertility.
Utility of Red Cell and Platelet Indices Evaluation of Severity of Dengue Infection
Authors: Patel Keyuri Bharat , Ranapurwala Mustafa Fakaruddin , Patel Anjali
Published: July 2022

Context: Dengue is the most common mosquito-borne viral illness in humans and transmitted by aedes aegypti. Infection may be asymptomatic or present with a mild febrile illness to a life-threatening shock syndrome and diagnosed by virological tests, serological tests, and complete blood count.

Aim: The present study was undertaken to evaluate the role of red cell and platelet indices to assess disease activity and severity of dengue infection.

Material and Methods: The present study was conducted at a tertiary level teaching hospital in Central Gujarat, India from November 2019 to August 2021.100 dengue positive cases and 100 controls (dengue negative case) were consecutively sampled. Epidemiological, clinical data and complete blood count were collected from online and offline registers of the Central Diagnostic Laboratory. Chi square test, independent sample T – test and Karl pearson coefficient of correlation were used for statistical analysis.

Results: Dengue cases have frequently presented with fever 32.65% or fever with chills / rigor 66.33%, headache 37.76%, body ache 44.90% and bleeding manifestations like petechiae 5.10% and bleeding from gum, nose and rectum  5.15%. while, 18% cases have ascites and 07% cases were found to have pleural effusion in dengue positive cases. Haemoconcentration, fall in total WBC count, platelet count and plateletcrit have significant statistical association with severity of dengue infection. Platelet count was directly proportional to plateletcrit in dengue positive cases.

Conclusion: Significant statistical association was presented between degree of leukopenia, thrombocytopenia, haemoconcentration and fall in plateletcrit with severity of dengue infection whereas plateletcrit has positive correlation with platelet count in dengue infection.
Synchronous Clear Cell Renal Carcinoma And Bilateral Invasive Duct Carcinoma Breast- Rare association
Authors: Badhe Shreya Devidas , Padmanabhan Anitha , Sawant Kavita Prakash , Gadgil Nitin M
Published: July 2022

Occurrence of  multiple primary malignant tumors is very uncommon .Co occuring tumors can be synchronous or non synchronous.Tumors presenting within  a period less than or equal to 6 months are called synchronous   and  if they occur after 6 months they are termed as metachronous. Synchronous malignancies are rarer than metachronous.  For  defining  tumors as synchronous  both   the tumors should show criteria of malignancy, possibility of metastasis  must have been ruled out and both the tumors should be pathologically distinct. Breast cancer is the commonest tumor to be associated with other malignancies such as colorectal, endometrial, ovarian carcinoma, yet occurrence of invasive ductal carcinoma with clear cell renal carcinoma is rare. We present a 70 year old female with   synchronous Breast carcinoma and Renal clear cell carcinoma .
EFL College Students’ Affective Experience in TOEIC Grammar Learning through Flipped Learning: A Case of Low-Level Learners
Authors:   British And American Language And Literature Association Of Korea, Lee Yuhwa , Oh Misuk
Published: July 2022

The purpose of this study aims to investigate the effects of flipped learning method on low-level EFL college students’ grammar skills in general English courses. In addition, it aims to compare with students’ affective experiences between flipped group and traditional group. For this purpose, an experimental group was led by the flipped class while a control group was led by the traditional teacher-centered class. Both participants conducted pre- and post-test focused on TOEIC grammar and surveys related to their affective experiences. Additionally, the experimental group was asked to answer another survey regarding their perceptions about flipped learning. The results showed a slight increase on the grammar score and a statistically significant difference in the flipped class, but a nominal improvement. In addition, the mean of the positive experiences in the experimental group was slightly higher than that of the control group. In particular, learners in the flipped class perceived that supplemental grammar videos for low-level students were helpful and satisfying. However, participants’ watching frequency was not high and they perceived that watching grammar videos in advance made some students feel burdened and tiresome because of fatigue of consistent online lectures during the COVID-19 pandemic.
Efficacy Predictors of the Third-Line Tyrosine Kinase Inhibitor Therapy in Patients with Chronic Phase of Chronic Myeloid Leukemia: Results of a Multi-Center Study
Authors: Lomaia E.G. , Shuvaev V.A. , Chitanava Tamara Vangelevna , Matvienko Yu.D. , Martynkevich I.S. , Voloshin S.V. , Efremova E.V. , Mileeva E.S. , Fominykh M.S. , Kersilova A.E. , Karyagina E.V. , Il’ina N.V. , Dorofeeva N.V. , Medvedeva N.V. , Klimovich A.V. , Shneider T.V. , Stepanova S.A. , Polezhaikovskaya N.F. , Siordiya N.T. , Sbityakova E.I. , Lazorko N.S. , Tochenaya E.N. , Motorin D.V. , Shnalieva N.A. , Alekseeva Yu.A. , Zammoeva D.B. , Zaritskey A.Yu.
Published: July 2022

Background. The introduction of tyrosine kinase inhibitors (TKIs) into real-world clinical practice considerably improved the prognosis for patients with chronic myeloid leukemia (CML). However, during long-term follow-up, almost 1/2 and 2/3 of patients in the chronic phase (CP) discontinue TKI therapy of the first or second line, respectively. According to the Russian and International clinical guidelines, the third-line therapy should include allogeneic hematopoietic stem cell transplantation (allo-HSCT). And yet, some patients on the third-line therapy achieve and sustain optimal response on long-term TKI administration. Up to now, no clear-cut prognostic factors of TKI efficacy in the third-line therapy have been identified. This creates a challenge for treatment decision making after the failures of two lines of TKI therapy. Aim. To assess the efficacy of the third-line TKI therapy in real-world clinical practice and to identify the factors affecting the long-term therapy outcomes in CML-CP. Materials & Methods. The retrospective study enrolled 73 CML-CP patients aged > 18 years, treated with TKIs in the third-line at 5 specialized institutions in Saint Petersburg and Leningrad Region. Among the patients there were 26 men (35 %). The median age of the patients was 51 years (range 25-88 years). Results. With the median (range) third-line TKI therapy duration of 14 (1-120) months, the rate of complete cytogenetic response (CCR) was 30 % (п = 22) in the total cohort. The median time before achieving CCR was 9 (4-25) months. With the median follow-up time from the beginning of third-line TKI therapy till the last visit of 25 (3-136) months, progression to accelerated phase or blast crisis was observed only in 13 (17 %) out of 73 patients. Death was reported in 26 % (n = 19) of cases, among them 5 patients whose death was not CML-associated. At the last visit, 13/73 (18 %) patients were still on third-line TKI therapy. Direct and longterm therapy outcomes, including achievement of CCR and assessment of overall and progression-free survivals, were significantly better in patients with any cytogenetic response (CR) than in those without it or without complete hematologic response. Conclusion. The implementation of TKIs in the third-line CML-CP therapy seems to be suitable for patients with at least some CR, especially if an optimal donor of hematopoietic stem cells is unavailable or if the risk of severe allo-HSCT complications is too high.
Azacitidine/Venetoclax Combination as First-Line Therapy in Elderly Patients with Acute Myeloid Leukemias: A First Step
Authors: Granatkin M.A. , Nikitin Evgenii Aleksandrovich , Mikhailov E.S. , Doronin V.A. , Minenko S.V. , Okuneva M.M. , Degtyareva N.V. , Pochtar M.E. , Lugovskaya S.A. , Kobzev Yu.N. , Vinogradova O.Yu. , Ptushkin V.V.
Published: July 2022

Background. The treatment of elderly patients with acute myeloid leukemias (AML) is one of the most formidable challenges in oncohematology. Hypomethylating drugs combined with venetoclax show relatively high efficacy and lower toxicity in elderly AML patients. Aim. To retrospectively analyze the efficacy and tolerability of the combined azacitidine/venetoclax therapy in AML primary patients of older age as well as to determine a spectrum of issues related to the implementation of this regimen in real-world clinical practice. Materials & Methods. The retrospective analysis enrolled a cohort of patients followed-up at the Botkin City Clinical Hospital (п = 35). The median age was 73 years (range 6090 years), 57 % of patients were over 70 years of age. The median follow-up duration was 5.2 months (range 1.6-42.6 months). By the time of final analysis 15 patients were still receiving the therapy. The median of overall survival was 11.1 months (95% confidence interval [95% CI] 8.1-14.1 months). The causes of death in 20 patients were AML progression (n = 3), non-COVID-19 infectious complications (n = 3), and COVID-19 (n = 10). In 4 patients the cause of death remained unidentified. Results. Complete remission (CR) was documented in 17 (48.5 %) patients; CR with incomplete hematologic recovery was identified in 9 (26 %) patients. The median time before achieving remission was 67 days (range 27-120 days). In 96 % of patients CR was achieved after 3 azacitidine/venetoclax cycles. The mean CR duration was 9.2 months (95% CI 5.7-12.6 months); the median time before loss of response was 19 months. Relapses were diagnosed in 5 patients. Neutropenia > grade 3 was identified in patients who achieved remission on subsequent therapy cycles in 100 % of cases (n = 26), anemia > grade 2 was reported in 9 (34 %) patients, and thrombocytopenia > grade 3 was detected in 13 (50 %) patients. Despite frequent neutropenia, patients with remission did not show any severe infectious complications. Conclusion. The combined azacitidine/venetoclax therapy in elderly patients yields remission in more than 70 % of cases and is not marked by any severe infectious complications, despite developing neutropenia. Due to its ease of administration and low toxicity, this regimen can be performed in outpatient units.