bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential expression of proteins in the central nervous system of early and late stage rabies infected dogs
Authors:   , Yingsakmongkon Sangchai
Published: November 2023

Rabies is a zoonotic disease. Dogs are an important reservoir host of rabies in Thailand, Asia, Africa and Europe. The clinical manifestations are the same in humans and dogs, and are categorized into 2 forms; furious and paralytic. Although there have been many rabies studies over the years, the pathogenesis of rabies is still unclear. In this study, proteomic analysis was used to investigate changes in host responses in central nervous system (CNS) tissues at early and late stages of disease compared to non-infected dog controls. They were divided in 5 groups; early furious (FE), late furious (FL), early paralytic (DE), late paralytic (DL) and control (N), respectively. Hippocampus, parietal lobes, brainstem and spinal cord tissues from these 5 groups were collected and stored until examination. Proteins were extracted from these tissues and analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) in combination with liquid chromatography mass spectrometry (LC-MS/MS). The proteins were statistically selected by suitable bioinformatics tools. There were 26, 7, 35 and 18 proteins expressed only in each hippocampus, parietal lobes, brainstem and spinal cord, respectively. They played role in cytoskeleton proteins, enzymes, proteins associated with cell death, inflammation and immunity. This is the first report of changes in proteome data set from rabies-infected CNS tissues in both forms, and in early and late stages of infection. This data will be useful for not only better understanding of the molecular mechanism in many regions of CNS tissues, but also diagnostic and therapeutic of rabies.
PHARMACOKINETIC STUDY OF STANDARDIZED EXTRACT OF CENTELLA ASIATICA ECa 233 IN RATS
Authors:   , Anukunwithaya Tosapol
Published: November 2023

The standardized extract of Centella asiatica ECa 233 is consist of triterpenoid glycosides, which are madecassoside (53.1%) and asiaticoside (32.3%). This extract has been found to exhibit various positive pharmacological effects on the central nervous system, and have a good safety profile in both acute and sub-chronic toxicity studies. The present study aimed to explore the disposition kinetics of ECa 233 in rats. The extract was intravenously or orally administered at doses from 50 to 200 mg/kg. Plasma, tissues, urine, and feces were collected at time points from zero to 48 h after dosing. The levels of madecassoside and asiaticoside, as well as their postulated triterpenic metabolites – madecassic acid and asiatic acid – in biological samples, were simultaneously measured by liquid chromatography-tandem mass spectrometry. The results showed that all animals had good tolerability for ECa 233. Whereas madecassic and asiatic acids were found in negligible amounts after pharmacokinetic assessment, madecassoside and asiaticoside demonstrated rather similar absorption and tissue distribution profiles. They were rapidly absorbed, reaching maximum levels within 5-15 minutes after oral administration, but they had poor oral bioavailability, less than 1%. Both triterpenoids were extensively distributed in the brain, stomach, and skin within 1 h and remained there for at least 4 h after dosing. A negligible amount of madecassic acid and asiatic acid were found in plasma and tissues, despite these two metabolites were extensively detected in feces after dosing. The pharmacokinetic results obtained could provide some guidance for appropriate dosing regimen of ECa 233 in future studies. This study also provided the first evidence demonstrating the distribution of madecassoside and asiaticoside to their target tissues from oral administration.
Two-phase fermentation for itaconic acid production by Aspergillus terreus NRRL1960 and its enzymatic and transcriptomic analyses
Authors:   , Songserm Pajareeya
Published: November 2023

Typical itaconic acid fermentation usually suffers from low product concentration and yield due to a failure to balance the metabolic flux towards itaconic acid production. In this study, two approaches were employed to better understand the root causes mentioned above and to enhance itaconic acid production. In the first approach, ATP regeneration was manipulated during itaconic acid production by using L-aspartate. The presence of 10 mM L-aspartate in the production medium repressed the pyruvate carboxylase activity. This resulted in the limited malate flux in the cytosol and the large pool of pyruvate in the mitochondria. A. terreus stimulated the conversion of the large pool of cis-aconitate into itaconic acid via the antiporters. Successively, itaconic acid production yield and final concentration were improved from the control by 8.33 % and 60.32 %, respectively. In the second approach, the 2-phase fermentation process was employed. Itaconic acid was first observed when ammonium and phosphate became limited. Contrary to those claimed in 1-phase fermentation, by this technique, low DO level enhanced itaconic acid production because it promoted the correct morphology in the form of mycelial clumps. Also, low DO level initiated the uncouple glycolysis and oxidative phosphorylation, which stimulated substrate level phosphorylation for ATP regeneration. The available pyruvate was then reacted with coenzyme A by pyruvate-formate lyase, resulting in formate and acetyl CoA which induced the metabolite flux to produce itaconic acid.
Process development of succinic acid production from sorghum straw by Actinobacillus succinogenes NP9-aA7
Authors:   , Phuengjayaem Sukanya
Published: November 2023

The aim of this study emphasized the isolation, screening, identification and optimization of the potential bacteria for succinic acid production. From primary screening, 171 isolates exhibited a clear zone on the screening medium. From qualitative analysis, 165 isolates gave positive by TLC. The potential 58 isolates were selected with quantitative analysis by HPLC for phenotypic characteristic. Fifty-eight isolates were divided into 11 groups. Representative isolate from each group have been identified based on its 16S rRNA sequence analysis. They were closely belonged to genus Enterococcus, Streptococcus. Lactobacillus, Clostridium, Lactococcus., Proteus. and Actinobacillus. Among 11 groups, the isolate NP9-aA7 representative from group X was isolated from the bovine rumen. It gave a high succinic acid of 42.539 g/L with a yield of 0.709 g/g glucose. It was identified to Actinobacillus succinogenes, non-motile, non-spore-forming, gram-negative rod and non-pathogenic. The statistical method combining a one factor at a time method, a Plackett-Burman Design (PBD) and a Box-Behnken Design (BBD) using a Response Surface Methodology (RSM) were developed to optimize succinic acid production by A. succinogenes NP9-aA7. Key medium consisted of 74 g/L of glucose, 30 g/L of yeast extract and 60 g/L of alkaline neutralizer (45 g/L of MgCO₃ and 15 g/L of Mg(OH) ₂) gave a maximum succinic acid to 60.087 g/l with a yield of 0.816 g/g glucose after 36 h of cultivation time. Batch fermentations in a 2 L fermenter, the model was validated with succinic acid of 58.080 g/L after 27 h of cultivation time. Addition of CO₂ partial pressure in the medium had significant improved the production of succinic acid to 72.930 g/l with a yield of 1.393 g/g glucose at the CO₂ partial pressure of 50.66 kPa after 24 h of cultivation time. Using sorghum straw hydrolysate as an alternative carbon source, A. succinogenes NP9-aA7 gave a succinic acid of 19.139 g/L closely to type strain of A. succinogenes DSMZ 22257. It could be suggested that SSH, a renewable material, could be used as an alternative carbon source for succinic acid production by A. succinogenes NP9-aA7.
Effect of probiotic on shrimp immune system and protection against Vibrio parahaemolyticus infection
Authors:   , Chomwong Sudarat
Published: November 2023

Lactic acid bacteria (LAB) are proposed as potential probiotic candidates in aquaculture and also known to be present in the gut of healthy aquatic animals. To isolate LAB from the gut of the white shrimp Litopenaeus vannamei, intestines were collected and the isolation of 89 LAB isolates was carried out using the MRS selective agar plate. The 16S ribosomal DNA (16S rDNA) sequence analysis reveals that most of the bacterial isolates identified from shrimp guts are the strain of LAB. Two candidate probiotics, Lactobacillus plantarum and Lactococcus lactis were selected for in vitro antimicrobial activity assay. The results indicated that cell-free supernatant of two probiotics contained antimicrobial substances actively against Vibrio parahaemolyticus causing Early mortality syndrome (EMS)/Acute Hepatopancreatic Necrosis Disease (AHPND) (VPAHPND). Administrations of two probiotic-supplemented feed enhanced the survival rate of shrimp upon infection with VPAHPND. In order to investigate the effect of the two probiotic strains on the shrimp innate immune system, immune activity and mRNA levels were monitored. The results indicated that oral administration of probiotic increased the level of prophenoloxidase and SOD activities. Moreover, expression levels of LvproPO1 and LvproPO2, but not LvPacifastin-like in midgut are significantly up-regulated after probiotic L. plantarum and L. lactis feeding. To examine the involvement of proPO-related genes in VPAHPND infection, temporal gene expressions were analyzed and showed that the LvproPO1 transcript level was downregulated at 24-48h and then returned to non-stimulated levels at 72 h. These finding suggests that two candidate probiotic LAB could enhance the immune system of shrimp L. vannamei and increase the resistance to VPAHPND infection.
Free radical scavenging and antiproliferative activities of peptide from monkey’s head mushroom (Hericium erinaceus)
Authors:   , Sangtitanu Taniya
Published: November 2023

Free radicals have been identified as a major trigger of various syndromes in living systems. Oxidative stress occurs when free radicals are excessive and antioxidants are insufficient, resulting in the necessary consumption of additional antioxidants. Peptide derived from monkey’s head mushroom seeds was hydrolysed using various concentrations (1, 2.5, and 5%) of proteases (Alcalase, Favourzyme, and Neutrase), and the 1% Alcalase hydrolysate exhibited the highest radical scavenging activities (DPPH, ABTS, and NO assay) compared to other hydrolysates. After ultrafiltration, Mw < 0.65 kDa showed the strongest activity. Then, Mw < 0.65 kDa was purified using gel filtration chromatography and separated into two fractions (F1, and F2), of which fraction F1 exhibited the highest activity and this was further purified by reversed phase high performance liquid chromatography. Four fractions (F11, F12, F13, and F14) from RP-HPLC were isolated. Thus, four antioxidant peptides were identified by quadrupole time-of-flight (Q-TOF) mass spectrometer. The cytotoxicity activity of the fraction F1 was determined by MTT assay in five cell lines. The results showed that F1 exhibited greater inhibition against the proliferation of Chago-K1 cell lines. Moreover, the fraction F1 has the protective activity of the hydroxy radical-induced DNA damage as shown in pBR322, pKS and pUC19. The apoptosis of F1 was measured by an FITC Annexin V Apoptosis Detection Kit with PI using flow cytometry and caspase 3, 8 and 9 activities were determined in Chago-K1 cells for 24, 48, and 72 hours.  The findings indicate that monkey’s head mushroom is a source of antioxidant peptides. Consequently, this suggests the importance of monkey’s head mushroom as a source of antioxidant peptides.
PRAKTIK PENGIRIMAN UANG MELALUI APLIKASI KUDO PERSPEKTIF HUKUM ISLAM
Authors: Fauzih Achmad , Iswandi Irvan
Published: November 2023

Seiring perkembangan zaman, muncul inovasi baru dalam hal alat pembayaran berupa uang elektronik (e-money) yang memiliki keunikan tersendiri dan sangat berbeda dengan alat pembayaran menggunakan kartu lainnya. Hal ini dikarenakan electronic value pada e-money disimpan secara elektronik di dalam kartu (stored value). Electronic value tersebut digunakan sebagai alat pembayaran, namun bukan merupakan simpanan sebagaimana diatur dalam Undang-Undang Perbankan. Bentuk pengaturan hukum terhadap uang elektronik diatur dalam PBI Nomor 11/12/PBI/2009, PBI Nomor 16/8/PBI/2014, PBI Nomor 18/17/PBI/2016 tentang Uang Elektronik dan melalui perjanjian baku dalam perjanjian penerbitan kartu e-money. Secara akad pengiriman uang melalui Aplikasi Kudo ada yang mengatakan bahwa hal tersebut merupakan akad hiwalah dan ada pula yang mengatakan bahwa pengiriman uang melalui Aplikasi Kudo merupakan akad wakalah. Perbedaan ini seharusnya tidak terjadi jika dilihat di lapangan. Oleh karena itu perlu diteliti di lapangan bagaimana praktiknya dan apakah pengiriman uang melalui transfer Aplikasi Kudo termasuk akad hiwalah atau wakalah. Penelitian ini merupakan penelitian Studi Pustaka dengan menggunakan pendekatan undang-undang yaitu penelitian terhadap produk-produk hukum. Bahan hukum primer yang digunakan adalah bahan hukum yang mempunyai otoritas yakni Fatwa MUI No 116/DSN-MUI/IX/2017 Tentang: Uang Elektronik Syariah. Hasil penelitian ini pada proses transaksi tidak sesuai dengan konsep hiwalah, melainkan lebih sesuai dengan konsep wakalah bil ujrah. Hal ini didasarkan pada tidak terpenuhinya rukun dan syarat hiwalah melainkan lebih terpenuhinya rukun dan syarat wakalah bil ujrah dimana nasabah sebagai muwakil, Aplikasi Kudo sebagai wakil dan adanya ujrah yang dilakukan oleh Reseller Kudo. Karena dalam hal ini tidak ada orang yang memberi hutang, menerima hutang, dan yang mengalihkan hutangnya. Dalam praktiknya hanya terdapat nasabah kemudian Reseller Kudo meminta biaya tambahan atau fee kepada nasabah di awal saat akan terjadinya transaksi. Hal ini menurut hukum Islam boleh karena tidak melanggar dari aturan-aturan hukum Islam.
PERAMALAN HARGA CABAI MERAH DI KOTA SEMARANG DENGAN PENDEKATAN MODEL ARCH GARCH
Authors: Nur Husna Milatina , Aji Prakoso Jalu
Published: November 2023

Cabai merah merupakan komoditas bahan baku yang mungkin tidak bisa digantikan oleh barang lain dan masyarakat tetap membeli cabai walaupun harga yang tinggi karena cabai tersebut tidak dapat digantikan. Kota Semarang merupakan kota yang memiliki harga cabai yang sering mengalami peningkatan dan penurunan harga cabai merah. Dibandingkan dengan kota/kabupaten lain yang ada di Jawa Tengah, Kota Semarang miliki perubahan harga cabai yang naik turunnya harga cukup sering terjadi setiap bulannya. Harga cabai memiliki fluktuasi, karena harga cabai akan rendah ketika musim panennya. Hal ini berdampak merugikan bagi para petani cabai. Harga cabai dapat menggambarkan volatilitas apabila keadaannya sering mengalami fluktuasi. Penelitian ini menggunakan data harga cabai bulanan di Kota Semarang. Metode penelitian ini menggunakan model ARIMA/ARCH-GARCH dengan alat bantu Eviews 10.0. Hasil analisis yang telah dilakukan dengan pendekatan ARIMA dapat ditarik kesimpulan bahwa, harga cabai di Kota Semarang selama satu tahun ke depan dari bulan Agustus tahun 2022 sampai dengan bulan Desember tahun 2023 akan mengalami peningkatan harga yang signifikan.
HOPEFULNESS AND FRUSTRATION IN DOMESTIC LIFE IN MANJU KAPUR’S A MARRIED WOMEN
Authors: Thavaseelan Dr. B.
Published: November 2023

This paper attempts to bring new women in Manju Kapur’s A Married Woman taking into account the hopefulness and frustration in domestic life. With diverse cultures, histories, and distinct forms of ethics and values, the women’s question, despite essential solidarity, needs to be tackled about the socio-cultural circumstances. The lives of women who survived and struggled under the suppressive mechanism of a restricted society can be manifested in the novels of Kapur. She has written fiction focusing on the predicament of contemporary women particularly in their struggle for empowerment and independence from the male- chauvinistic social structure. Now “Woman Question” is no longer a problem limited to the condition of women within the family or their rights to equality with men in different facets of social life. It is part of the total, far broader question considering the direction of change that Indian society is making - social, political, economic, and the intellectual viewpoint and examination of that process.
Gemeinwohl-Ökonomie: Arbeitsplatzqualität und Gesundheit
Authors: Ollé-Espluga Laia , Hadler Markus
Published: November 2023

In diesem Artikel stellen wir die wichtigsten Ergebnisse des Projekts "Gemeinwohl-Ökonomie: Arbeitsplatzqualität und Gesundheit" vor. In diesem vom FWF geförderten Projekt wurde das Ziel verfolgt, neue Erkenntnisse über die Gemeinwohlwirtschaft zu gewinnen. Dabei wurde untersucht, ob es Unterschiede mit Blick auf die Arbeitsplatzqualität, auf Gesundheitsergebnisse sowie auf die Arbeitszufriedenheit gibt zwischen denjenigen Organisationen, die diesem Modell folgen und anderen Unternehmen. Wir haben uns dabei auf Österreich und Deutschland konzentriert, da die Gemeinwohl-Wirtschaft in diesen beiden Ländern am weitesten verbreitet ist. Unser Beitrag zeigt nur geringe Unterschiede in zwischen den verschiedenen Unternehmen, was unter Umständen darauf zurückzuführen ist, dass GWÖ Unternehmen eine eher rezente Organisationsform sind.
Polarisierung der Gesellschaft in Österreich?
Authors: Tichy Gunther
Published: November 2023

Seit der ersten Hälfte der siebziger Jahre häufen sich soziologische und ökonomische Studien über eine Polarisierung der Gesellschaft bzw. einen „Verlust der Mitte“: Digitalisierung und Automatisierung von Routinetätigkeiten würden die Nachfrage nach hohen Qualifikationen steigern und mittlere entwerten; in weiterer Folge wären auch mittlere Einkommen und Berufe mit mittleren Qualifikationsanforderungen bedroht. Für Österreich zeigt die Studie jedoch einen generellen Trend der Höherqualifizierung, bei dem nur der unterste Bereich der unqualifizierten und instabilen Arbeitsverhältnisse zurückfällt. Die Berufsstruktur änderte sich trotz des raschen Strukturwandels wenig, da die breite Ausbildung der Arbeitskräfte ihren flexiblen Einsatz ermöglicht. Bei den Einkommen zeigt sich keine quantitative, sondern bloß eine qualitative Polarisierung durch Zunahme und Verfestigung der instabilen Beschäftigungsverhältnisse. Insgesamt ergibt sich, dass der bildungspolitische Ansatz der generellen Höherqualifizierung in Österreich erfolgreich war: Er konnte einen „Verlust der Mitte“ bisher verhindern und die Polarisierung in engen Grenzen halten. Allerdings entsprach der generellen Höherqualifizierung eine Abspaltung der Arbeitnehmerinnen und Arbeitnehmer im unqualifizierten Niedriglohnbereich, zum geringen Teil AbsteigerInnen, vor allem aber Beschäftigte mit Migrationshintergrund. Insofern gilt es, einer Polarisationstendenz durch Entstehen eines HilfsarbeiterInnen- und Dienstleistungsprekariats mit instabiler Beschäftigung und niedrigen Löhnen entgegenzuwirken.
Arbeitszeitverkürzung in Betrieben - Modelle und Praxis
Authors: Astleithner Franz , Stadler Bettina
Published: November 2023

Mit unserem Beitrag stellen wir die Ergebnisse von Fallstudien zur Arbeitszeitpraxis und Formen der Arbeitszeitverkürzung in fünf österreichischen Unternehmen vor. Ausgewählt wurden Unternehmen in Branchen, die sich in Hinblick auf die Art der Tätigkeit, das Qualifikationsniveau der Beschäftigten und die geltenden kollektivvertraglichen Regelungen zur Arbeitszeitverkürzung möglichst unterscheiden.
Für die Untersuchung werden alle Regelungen und Praxen, die zu kürzerer Normalarbeitszeit führen können, als direkte Arbeitszeitverkürzung definiert, egal ob damit die wöchentliche oder die jährliche Arbeitszeit reduziert wird (z.B. in einer Betriebsvereinbarung vereinbarte zusätzliche freie Tage). Hinzu kommen Aspekte der indirekten Arbeitszeitverkürzung, dies sind Regelungen und Praktiken, die zu einer faktischen Verkürzung der tatsächlichen Arbeitszeit führen können, ohne das Arbeitsausmaß innerhalb eines Vollzeit-Arbeitsplatzes zu verändern (z.B. bessere Möglichkeiten, zusätzliche Arbeitsstunden in Form von Gleittagen als Freizeit zu konsumieren oder das Recht auf Sabbaticals). Die von uns gewählten Fallbeispiele machen die große Heterogenität der Arbeitszeitpraxis in den Unternehmen deutlich. Aus einer detaillierten Beschreibung der Formen von Arbeitszeitverkürzung, der Bedürfnisse und Wünsche der ArbeitnehmerInnen und der Perspektiven von Betriebsrat und Management werden fördernde und hemmende Faktoren für Arbeitszeitverkürzung synthetisiert. Förderlich für Arbeitszeitverkürzung ist vor allem der Wunsch von Unternehmen als attraktiver Arbeitgeber zu gelten und die Motivation und Produktivität der Belegschaft hoch zu halten. Auf Ebene der Beschäftigten führt aber auch die Notwendigkeit, belastende Tätigkeiten auszugleichen, zu kürzeren Arbeitszeiten. Ein aktiver Betriebsrat hat hinsichtlich der Arbeitszeitgestaltung eine wichtige Schutzfunktion.
Hemmende Faktoren finden sich bei Geringqualifizierten mit niedrigen Stundenlöhnen, die kürzere Arbeitszeiten ohne Lohnausgleich vor existenzielle Probleme stellen würden. Auch eine hohe Fluktuation im Unternehmen, hoher Kostendruck und eine dünne Personaldecke wirken ebenso wie eine wenig flexible Arbeitsorganisation hemmend für kürzere Arbeitszeiten.
Mindestlöhne, Beschäftigung und die ‚Harmonie der Täuschungen‘
Authors: Heise Arne
Published: November 2023

In der Wirtschaftsgeschichte hat es immer wieder Phänomene – Anomalien – gegeben, die als unvereinbar mit der herrschenden Ökonomik erschienen. Wenn dies dennoch bis heute zu keinem Paradigmenwechsel in der Dogmengeschichte der Wirtschaftswissenschaften führte, so zeigt sich hierin die besondere Resilienz des herrschenden Paradigmas.

In diesem Artikel geht es darum, mit Hilfe der Wissenschaftstheorie Ludwik Flecks die Hintergründe, aber auch Gefahren dieser Resilienz aufzuzeigen und – unter besonderer Betrachtung der Forschungen zur Arbeitsmarktökonomik des Mindestlohnes – zu untersuchen, ob ein zwingend benötigter ‚stilgemäßer Denkzwang‘ nicht unter Umständen zu einer ‚Harmonie der Täuschungen‘ entarten kann und deshalb den empirische Anomalien größere Aufmerksamkeiten eingeräumt werden müsste?
Environmental Inequality in Austria: Sociodemographic Disparities in Perceived Environmental Quality
Authors: Durstmüller Felix
Published: November 2023

This quantitative study investigates the relationship between perceived environmental conditions (air pollution, noise, extreme heat, access to green space) and socioeconomic status in Austria. Building upon the work of Baud and Wegscheider-Pichler (2019) and integrated into the theoretical framework of environmental justice, it aims to enrich the empirical body of literature on environmental inequality in Austria by adding the subjective perspective of affected individuals in order to highlight individual vulnerabilities and capability to adapt. Data from the Austrian Microcensus 2019, a large-scale population-based survey, is used. In this survey, information on perceived exposure to adverse environmental conditions was collected from a total of 7,021 respondents. To analyse the association between subjective exposure and sociodemographic characteristics, binomial and ordinal logistic regression models are applied. The findings suggest that lower income is associated with a lower perception of overall environmental quality and a higher level of perceived exposure to air pollution. A correlation between income and level of noise disturbance is only present in Vienna, and no relationship between income and perceived heat stress can be identified. However, in almost all categories of adverse environmental impacts, women feel more affected than men, and housing conditions are significantly related to perceived noise annoyance. Mixed results are found regarding the role of migration background. While individuals with migration backgrounds report higher personal exposure to air pollution, they rate the overall environmental quality as better than people without migration backgrounds. In line with other empirical studies, the results confirm that exposure to adverse environmental conditions is distributed unequally across society in Austria. To address these inequalities, concerns of environmental justice should be integrated into public discourse and policymaking.
Der lange Schatten der Ungleichheit
Authors: Ertl Michael
Published: November 2023

Der Soziologe Michael Savage verbindet im vorliegenden Buch die berühmten Grafiken zur Ungleichheit der letzten beiden Jahrzehnte, und dank seiner vielschichtigen Betrachtungsweisen gelingt es ihm hervorragend, verschiedene sozialwissenschaftliche Disziplinen zu vereinen. Dabei zeigt er auch die Notwendigkeit auf, hinter diese Grafiken zu blicken. Sie vermitteln zwar eingängige Narrative, blenden aber den langen Schatten der Vergangenheit aus, der wesentlich zum Verständnis aktueller Ungleichheiten beitragen kann.
Examination of the level of governance in Gombe local government, Nigeria
Authors:   Department of Public Administration, Gombe State University, Nigeria 2Department of Political Administrative Studies, Kampala International University, Uganda. 3Department of Development, Peace and Conflict Studies, Kampala International University,  Uganda., Mulegi Tom and Eleanor Kirahora Barongo Usman Bappi
Published: November 2023

This study examined the level of governance in Gombe local government, Nigeria. The study was guided by the following research objectives: to determine the Demographic profile of the respondents and to examine the level of governance in Gombe local government. This study adopted mixed approaches, combining qualitative and quantitative approaches and using descriptive survey for data collection. Data was collected using researcher‘s devised questionnaires. Frequency and percentage distributions were used to analyze respondents‘profile. Means was used for the level of Governance in Gombe local government in Nigeria. Findings revealed that the level of governance in Gombe local government in Nigeria had an average mean of 2.20 and was interpreted as fair. The researcher concluded that role of government in community development is to simply work closely with other players in the community development system and working closely can improve speed and smoothness in administrative and regulatory tasks, probably at limited cost. Keywords: Examination, level, governance, Gombe, local government and Nigeria
My new article is up at Discover Magazine‘s guest blog, The Crux
Authors: Taylor Mike
Published: November 2023

A very quick note to let you all know that my new article is now up at  Discover  Magazine‘s guest blog, The Crux.  Entitled  It’s Not Academic: How Publishers Are Squelching Science Communication  , the topic will not be unfamiliar to SV-POW! readers.
Nature and Science both oppose the RWA
Authors: Taylor Mike
Published: November 2023

Although I’m on record of being no fan of the tabloids, there’s no doubt that they are hugely influential.  So it has to be good news to find that in the last few hours, both  Nature  and  Science  have publicly come out against the Research Works Act.
Type I Error Rates are Not Usually Inflated
Authors: Rubin Mark
Published: November 2023

The inflation of Type I error rates is thought to be one of the causes of the replication crisis. Questionable research practices such as p-hacking are thought to inflate Type I error rates above their nominal level, leading to unexpectedly high levels of false positives in the literature and, consequently, unexpectedly low replication rates. In this article, I offer an alternative view.
Things to Make and Do, part 9b: the right to arm bears
Authors: Wedel Matt
Published: November 2023

This is the second post on the Wedel lab’s recently acquired skull of  Ursus americanus  , the American black bear. The first installment covered ended with the disinterred-but-still-filthy skull bits sitting on my dining room table. This post covers putting the teeth back in, and just enough anatomy to justify putting up more cool pictures.
Why the long necks? Probably not sexual selection
Authors: Taylor Mike
Published: November 2023

Thanks to everyone who joined in the discussion last time on why sauropods had such long necks.  I’ve discussed this a little with Matt, and we are both amazed that so many different hypotheses have been advanced (even if some of them are tongue-in-cheek).  We’ll probably come back to all these ideas later.
What actually is Elsevier’s open-access licence?
Authors: Taylor Mike
Published: November 2023

Like many scholarly publishers that work primarily on the subscription model, Elsevier allows authors to opt in to open access by paying a fee, currently $3000.  (While that’s more than twice the $1350 that PLoS ONE charges, it’s comparable to the $2900 that PLoS Biology charges, identical to Springer’s $3000 fee, and slightly less than Taylor &
What everyone wants to find under the tree
Authors: Wedel Matt
Published: November 2023

This is how Vanessa’s SO, Lane Medina, wraps a Christmas present. The young man shows promise!
What is a “private-sector research work”?
Authors: Taylor Mike
Published: November 2023

A short one this time, honestly. I’ve written plenty about the Research Works Act, both on this blog and in  The Guardian  .  Those writings have mostly focussed on the practical implications of the bill.  But those aren’t the real reasons that it invokes such rage in me.  That comes from this definition (from the text of the bill): So if Randy Irmis gets an NIH grant to research some subject;
All right then, so what are the alternatives?
Authors: Taylor Mike
Published: November 2023

Barrier-based publishers have been shouting and stomping around a lot recently.  Kind of like a Vogon guard.  But we’re  trying  to see the situation from their point of view.
Things to Make and Do, part 9: bear skull, or, VIG’s first dig
Authors: Wedel Matt
Published: November 2023

After three months as a paleontology grad student, this morning Vanessa I. Graff got to sink a shovel in the service of science. Now, it was a bear skull, deliberately buried in someone’s back yard, so technically today’s exploits fall under the heading of contemporary zooarcheology rather than paleontology, but we’ll take what we can get. This story has a backstory.
George Monbiot: “Academic publishers make Murdoch look like a socialist”
Authors: Taylor Mike
Published: November 2023

A quick note to let you all know that George Monbiot’s piece  Academic publishers make Murdoch look like a socialist  has been published in The Guardian, one of the four respected “broadsheet” national daily newspapers of the UK.  (It was online yesterday, and is in today’s print edition.) A few key quotes: I encourage you to read the whole thing. None of this will be news to long-time SV-POW!
The gloves are off!
Authors: Taylor Mike
Published: November 2023

A package!  A package has arrived! What can it be? All  right  !  Let’s get down to business? Now, where did I leave that monitor-lizard neck skeleton?  Ah yes …  That’s  what I’m talkin’ about. … Stay tuned for exciting news about turkey zygapophyses.
Denver Diplodocus
Authors: Wedel Matt
Published: November 2023

Taken by me–or rather, my camera in automatic mode–earlier today, because the ole sauropod blog has been a bit light on sauropods lately. I spend a lot of time thinking about  Sauroposeidon  ,  Supersaurus  , and the like. It’s good to be reminded that even an ‘average’ sauropod like  Diplodocus  is still pretty awesome. And weird. I don’t know if we can be reminded often enough.
Sideshow Collectibles Apatosaurus Maquette, Part 3: the neck
Authors: Wedel Matt
Published: November 2023

This is the third in a series of posts on the  Apatosaurus  maquette produced by Sideshow Collectibles. The rest of the series: Part 1: introduction Part 2: the head Part 4: body, tail, limbs, base, and skull Part 5: posture Part 6: texture and color Part 7: verdict It is probably no surprise, given my proclivities, that I have more to say about the neck than about anything else.
Necks lie, redux
Authors: Wedel Matt
Published: November 2023

In a recent post I showed photos of the trachea in a rhea, running not along the ventral surface of the neck but along the right side. I promised to show that this is not uncommon, that the trachea and esophagus of birds are usually free to slide around under the skin and are not constrained to like along the ventral midline of the neck, as they usually are in mammals. Here goes.
Mustafa Kemal Ataturk and the Turks in the Serbian public during the thirty years of the twentieth century
Authors: Đurđević Sava
Published: November 2023

In accordance with the development of Yugoslav-Turkish relations during the thirties of the twentieth century, and the close friendship between King Aleksandar Karađorđević and Turkish President Mustafa Kemal Ataturk, the Serbian press reported a lot about Turkey. In its reporting, the Serbian press popularized the image of Ataturk, comparing him to King Alexander. At the same time, in its reporting on Turkey, the press presented an image of the change of the Turks themselves, but in an ambivalent tone, which stemmed from the traditionally negative image of the Turks, shaped during the Ottoman rule in the Balkans.
Implementasi Metode Weighted Product Dalam Sistem Pendukung Keputusan Pemilihan Kain Songket
Authors: Neza Ulfa
Published: November 2023

Kurangnya pengetahuan dan informasi akan spesifikasi dari kain songket membuat orang awam yang ingin membeli kain songket merasa bingung untuk menentukan kain songket mana yang sesuai dengan kebutuhan. Salah satu cara untuk membantu dan mempermudah calon pembeli supaya bisa menentukan kain songket yang akan dibeli sesuai dengan kebutuhan adalah dengan membangun sebuah sistem pendukung keputusan berbasis web. Sistem pendukung keputusan menggunakan metode weighted product sebagai algoritma perhitungan untuk perancangan dan implementasi sistem. Hasil dari sistem ini adalah menghasilkan rekomendasi kain songket yang sesuai dengan inputan kriteria yang ada pada kain songket seperti harga, keawetan (umur), kerapian kain, kenyamanan (berat), bahan dasar dan benang untuk motif dengan mengacu pada pembobotan di setiap alternatif dan kriteria. Sehingga setelah dibuatnya sistem ini dapat membantu calon pembeli dalam menentukan kain songket yang sesuai dengan kebutuhan.
Penerapan Metode Design Thinking Dalam Perancangan UI/UX Aplikasi Edukasi Dan Konsultasi Kondisi Kesehatan Mental
Authors: Zukhrian Shafarazaq  , Visco Adam Bramasta  , Lintang Ardi Avdillah  , Yoga Sahria
Published: November 2023

Kesehatan mental merupakan aspek penting dalam kesejahteraan individu. Dalam upaya meningkatkan kesadaran dan aksesibilitas terhadap edukasi dan konsultasi kesehatan mental, pengembangan aplikasi mobile menjadi salah satu solusi yang menjanjikan. Aplikasi berbasis mobile telah menjadi bagian integral dalam upaya penyediaan edukasi dan konsultasi terkait kesehatan mental. Namun, seringkali, aplikasi semacam ini kurang mempertimbangkan pengalaman pengguna yang optimal dalam perancangan antarmuka (UI) dan pengalaman pengguna (UX). Dalam konteks ini, metode Design Thinking telah diadopsi untuk mengatasi tantangan tersebut. Penelitian ini bertujuan untuk merancang antarmuka pengguna (UI) dan pengalaman pengguna (UX) yang baik dari aplikasi berbasis mobile yang berfokus pada edukasi dan konsultasi kondisi kesehatan mental, sehingga diharapkan dapat memberikan informasi terkait kondisi kesehatan mental dengan mudah. Metode yang digunakan dalam perancangan aplikasi ini adalah Design Thinking, yang menekankan pemahaman mendalam terhadap kebutuhan pengguna serta iterasi berkelanjutan dalam proses perancangan. Melalui serangkaian tahap dalam metode Design Thinking, penelitian ini menggali perspektif pengguna, mengidentifikasi masalah, menciptakan solusi yang berfokus pada pengguna, dan menguji prototipe aplikasi. Hasil penelitian ini menunjukkan bahwa penerapan Design Thinking dapat menghasilkan UI/UX yang lebih intuitif, responsif, dan berfokus pada pengguna. Dengan pendekatan desain yang berorientasi pada pengguna dan berbasis mobile, aplikasi ini diharapkan dapat meningkatkan kualitas hidup individu dan mengurangi stigma seputar kesehatan mental.
APLIKASI PENGENALAN HEWAN BERBASIS AUGMENTED REALITY MENGGUNAKAN METODE MARKER BASED TRACKING BERBASIS ANDROID
Authors: Aditya Suhendra Agung , Mahirssa Rafif , Samsul Rafli  , Yoga Sahira
Published: November 2023

Pembelajaran pengenalan berpengaruh dalam tumbuh kembang anak, anak – anak mulai belajar melakukan identifikasi, mengasah pengetahuan dan daya ingat, salah satunya adalah dengan pengenalan hewan, umumnya pengenalan hewan dilakukan dengan menggunakan media gambar atau video, tetapi banyak anak - anak terutama usia dini yang kurang tertarik dalam proses pengenalan hewan dengan menggunakan media gambar karena tidak bisa melihat bentuk langsung dari hewan,  untuk melihat bentuk asli dari hewan tersebut biasanya harus mendatangi kebun binatang. Augmented Reality merupakan teknologi yang mampu menggabungkan objek 2D atau 3D dan merekayasa kedalam dunia nyata, dengan menggunakan teknologi augmented reality yang di implementasikan kedalam aplikasi pengenalan hewan berbasis android diharapkan dapat meningkatkan daya tarik anak – anak sebagai media pembelajaran pengenalan hewan, tujuan dari penelitian ini adalah membangun aplikasi pengenalan hewan dengan menggunakan metode MDLC (Multimedia Developmnt Life Cycle) untuk pengembangan aplikasi dan menggunakan metode marker based tracking untuk dapat memunculkan objek 3D  diatas marker atau penanda 2D, aplikasi dibangun secara menarik dan informatif, hasil dari penelitian aplikasi tidak hanya menampilkan objek 3D hewan, tetapi aplikasi juga mampu memberikan informasi mengenai hewan yang ditampilkan dan aplikasi juga memiliki fitur seperti mengeluarkan suara hewan, zoom in, zoom out, rotasi untuk melihat bentuk 3D hewan secara detail, dengan demikian diharapkan anak – anak menjadi lebih tertarik dalam proses pembelajaran pengenalan hewan.
Data Science
Authors:   Muthayammmal Engineering College, Tamil Nadu, India., Anandh O. Sugel , Kumar Saurabh ,   Noida International University, Uttar Pradesh, India., Sengar Alok Singh ,   Noida International University, Uttar Pradesh, India., S. Artheeswari ,   Mailam Engineering College, Tamil Nadu, India.
Published: November 2023

A succinct introduction to the developing discipline of data science, outlining its origins, link to machine learning, contemporary usage, data infrastructure concerns, and ethical challenges. Data scientists attempt to enhance judgement by examining large amounts of information. Today, data science is used to influence everything from the kind of adverts we see online to the books and films we are advised, the emails we get, and even the prices we pay for medical coverage.
Mascaramento para encantar-se: o baiar afro-maranhense e a in(corporação) em cena
Authors: Ferreira Vinicius Viana
Published: November 2023

Este artigo propõe articular uma análise sobre o processo criativo do artista Vinicius Viana em seu processo de composição visual, ao mascarar-se inspirado nos corpos que baiam o Tambor de Mina do Maranhão, dentro de um processo em que se estabelece a união do corpo criativo e o baiar para o sagrado dos terreiros. As vivências compartilhadas aqui permeiam o lugar possível da máscara corporal, em uma ponte com a visualidade que transita entre a sociedade e o sagrado; a matéria; e o invisível; entre o contemporâneo e a tradição que relacionam de forma atemporal a conexão África e Brasil e que penetram as raízes ancestrais do dançar de um artista e a sua escrita.
Jogo de máscara no Candomblé como norteador de estratégias de escrituras cênicas
Authors: Almeida Alisson Araújo de
Published: November 2023

O presente artigo é um revisitar da pesquisa de doutorado onde pesquisei os jogos de Máscara no Candomblé a fim de produzir estratégias de composições físicas para a cena contemporânea. Sob a perspectiva da Encruzilhada, cruzei a percepção desses jogos de Máscara com a metodologia de Jacques Lecoq e de outros encenadores do Teatro Ocidental. A partir de uma tríade metodológica que engloba pesquisa bibliográfica, pesquisa de campo e laboratório cênico, este artigo apresenta algumas das estratégias que foram desenvolvidas durante o doutoramento.
El quinto centenario de la fundación de Veracruz y el proceso civilizatorio en Mesoamérica
Authors: Andreu Manuel
Published: November 2023

El 2019 marca la llegada del quinto centenario de la fundación de una de las ciudades más heroicas, importantes y relevantes de la historia americana, y que también es de las más queridas y valoradas por la alegría de su gente y la riqueza cultural que han aportado a la identidad hispanoamericana. Esa ciudad es Veracruz, cuyo establecimiento original como Cabildo de la Villa Rica de la Vera Cruz el 22 de abril de 1519 por Hernán Cortés –uno de los personajes más importantes de la historia de México y España–, marcó el rumbo de la civilización hispánica y católica en la modernidad, pues señaló el inicio de una expansión sin parangón de la civilización occidental. El contenido este trabajo orbita sobre dos grandes temas. El primero de ellos es un estudio sobre el modelo de organización municipal de la Monarquía hispánica en el siglo XVI, pues resulta fundamental entender que el mundo americano se constituyó y se ha basado hasta nuestros días en la administración urbana. El segundo analiza la recepción cultural y el proceso de mestizaje que configuran hasta la actualidad toda Hispanoamérica.
NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023
Authors: Zelenetz Andrew D. , Gordon Leo I. , Abramson Jeremy S. , Advani Ranjana H. , Andreadis Babis , Bartlett Nancy L. , Budde L. Elizabeth , Caimi Paolo F. , Chang Julie E. , Christian Beth , DeVos Sven , Dholaria Bhagirathbhai , Fayad Luis E. , Habermann Thomas M. , Hamid Muhammad Saad , Hernandez-Ilizaliturri Francisco , Hu Boyu , Kaminski Mark S. , Karimi Yasmin , Kelsey Christopher R. , King Rebecca , Krivacic Susan , LaCasce Ann S. , Lim Megan , Messmer Marcus , Narkhede Mayur , Rabinovitch Rachel , Ramakrishnan Praveen , Reid Erin , Roberts Kenneth B. , Saeed Hayder , Smith Stephen D. , Svoboda Jakub , Swinnen Lode J. , Tuscano Joseph , Vose Julie M. , Dwyer Mary A. , Sundar Hema
Published: November 2023

Novel targeted therapies (small molecule inhibitors, antibody–drug conjugates, and CD19-directed therapies) have changed the treatment landscape of relapsed/refractory B-cell lymphomas. Bruton’s tyrosine kinase (BTK) inhibitors continue to evolve in the management of mantle cell lymphoma (MCL), in both the relapsed/refractory and the frontline setting. Anti-CD19 CAR T-cell therapies are now effective and approved treatment options for relapsed/refractory follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and MCL. Bispecific T-cell engagers represent a novel immunotherapeutic approach for relapsed FL and DLBCL after multiple lines of therapies, including prior CAR T-cell therapy. These NCCN Guideline Insights highlight the significant updates to the NCCN Guidelines for B-Cell Lymphomas for the treatment of FL, DLBCL, and MCL.
Importancia de la implementación de la tecnología para la continuidad de los negocios. Un análisis de la bibliografía, 2021
Authors: López Esteban
Published: November 2023

El presente artículo se centra en la importancia de la tecnología para la continuidad de los negocios en el contexto actual. El objetivo del trabajo es analizar la relevancia de la tecnología en la continuidad de los negocios y las estrategias metodológicas implementadas para su consecución. Para ello, se revisaron diversas fuentes bibliográficas, las cuales permitieron conocer los distintos avances tecnológicos que se han implementado en las empresas para lograr una gestión más eficiente y efectiva. Los resultados encontrados muestran que la tecnología se ha convertido en un factor fundamental para la continuidad de los negocios, permitiendo una gestión más eficiente y eficaz, lo que ha contribuido a mejorar la productividad y competitividad de las empresas. Asimismo, se identificaron las principales herramientas tecnológicas utilizadas en las empresas, como el software de gestión empresarial, la nube, las redes sociales y el comercio electrónico, entre otros. En conclusión, el uso de la tecnología es esencial para la continuidad de los negocios en la actualidad, permitiendo una gestión más eficiente y efectiva. Esto representa un desafío para las empresas, las cuales deben estar actualizadas y adaptarse a las nuevas tecnologías para mantenerse competitivas en el mercado. No obstante, es importante tener en cuenta las posibles limitaciones que la implementación de la tecnología puede generar en cuanto a costos y capacitación del personal. En este sentido, es necesario contar con un plan estratégico que permita una adecuada implementación y utilización de la tecnología en los negocios.
Impacto da pandemia do COVID-19 na saúde mental dos estudantes de medicina (DASS-21)
Authors: Castro Victória de Souza Damasceno , Pereira Laura Nagem Júlio , Lima Daniel José Matos de Medeiros
Published: November 2023

Introdução: A pandemia do COVID-19, declarada pela Organização Mundial da Saúde em março de 2020, trouxe consigo uma série de desafios sem precedentes para a sociedade global. Além das implicações diretas na saúde física, as consequências psicológicas e emocionais da pandemia têm sido motivo de crescente preocupação. Estudantes de medicina, em particular, encontram-se em uma posição única, estando na linha de frente do combate ao vírus e, ao mesmo tempo, enfrentando as pressões acadêmicas e clínicas. Este cenário pode ter ampliado os riscos de problemas de saúde mental neste grupo. Objetivos: Avaliar a prevalência de sintomas de ansiedade, depressão e estresse entre os estudantes de medicina após a pandemia do COVID-19. Métodos: Foi realizado a aplicação do questionário DASS-21 (Depression, Anxiety and Stress Scale) para identificar o risco de depressão, ansiedade e estresse em estudantes do 5º ao 9º período do Curso de Medicina da Faculdade de Medicina de Campos. Autorizado pelo CEP 40145420.0.0000.5244. Resultados:  Entre 143 respostas de estudantes da faculdade de medicina de campos, 62,2% eram mulheres e 37,8% eram homens. A média de idade foi de 21,76±3,1 anos. Quanto ao questionário DASS-21, foi observado que as três variáveis avaliadas, estresse, ansiedade e depressão, mostraram: Ansiedade - 44% normal e 56% apresentam algum grau de ansiedade. Com relação a depressão, 50,35% normal e 49,65% apresentem algum grau de depressão. Já o estresse, 31,47% normal e 68,55% apresentam algum grau de estresse. Conclusão: A pandemia impactou na saúde mental dos estudantes de medicina, ficando evidente que a maioria apresenta algum grau de ansiedade, depressão e estresse. Esses dados ressaltam a necessidade urgente de intervenções de apoio psicológico para este grupo.