bluuebunny/crossref_metadata_2025 huggingface dataset:
MedPipe: End-to-End Joint Search of Data Augmentation and Neural Architecture for 3D Medical Image Classification
Authors: He Xin , Chu Xiaowen
Published: April 2022

Data augmentation plays a crucial role in deep learning-based medical imaging analysis, but manually designing tailored data augmentation strategies for each dataset is impractical. Although automatic data augmentation (ADA) techniques have been explored, they often focus solely on data augmentation without considering the importance of neural architecture. Similarly, neural architecture search (NAS) methods mainly concentrate on optimizing the neural architecture while overlooking the impact of data augmentation. However, both data augmentation and neural architecture are interrelated and should be considered together. The joint optimization of data augmentation and neural architecture can lead to improved model performance by harnessing the complementary effects of customized data augmentation strategies and compatible neural architectures. Despite this, the seamless integration of data augmentation and neural architecture search remains under-explored. To address this research gap, we propose \medpipe, an approach that enables end-to-end joint search of data augmentation and neural architecture. We introduce a compact data augmentation search space and unify data augmentation and neural architecture into a cohesive network. This allows simultaneous exploration, optimizing their synergy for enhanced performance. Experimental evaluation on nine medical datasets highlights the necessity of the joint search for data augmentation and neural architecture, demonstrating the superior performance of our approach. Our work opens up possibilities for future applications in diverse medical domains.
MedPipe: End-to-End Joint Search of Data Augmentation Policy and Neural Architecture for 3D Medical Image Classification
Authors: Chu Xiaowen , He Xin
Published: April 2022

3D medical image classification with deep learning methods is challenging due to two problems, the difficulty of designing the neural architecture (NA) and the lack of large-scale 3D medical datasets for pretraining. Neural architecture search (NAS) has become a popular method to design NA automatically. Inspired by NAS, recent studies have proposed automatic data augmentation (ADA) to search the data augmentation policy (DAP) to increase the size of 3D medical datasets. However, NAS or ADA can only solve one of the above two problems. It is difficult to search both DAP and NA for 3D medical images because the computational cost of 3D data augmentation operations is high, and the joint search space is too large to find the optimal solution economically. To this end, we propose an efficient end-to-end framework for the joint search of DAP and NA applicable to 3D medical images, namely \textit{MedPipe}. Specifically, 1) we modify all 3D data augmentation operations to be differentiable and integrate them with NA seamlessly; 2) we design a novel search space that unifies DAP and NA, i.e., each possible network is a combination of the DAP and NA, called \textit{unified network}; 3) we adopt a single-path based differentiable search algorithm to search the unified network. We evaluate our framework on nine public 3D medical datasets covering various modalities and data resolutions. Experimental results show that our MedPipe can efficiently find unified networks with better performance than previous human-designed and NAS-searched networks.
Liposarcomas: Experience of the Oncology and Radiotherapy Department and the Anatomy-Pathology Department at the Mohammed VI University Hospital in Marrakech: 10-Year Retrospective Study from January 2010 to January 2020
Authors: Mahrouch Basma , Bennani Malak , Zaytoune Ikram , Darfaoui Mouna , Omrani Abdelhamid El , Khouchani Mouna
Published: April 2022

Liposarcomas are rare soft tissue tumors that arise from adipose tissue. They account for 1% of all malignancies and 15% to 20% of soft tissue sarcomas. Between January 2010 and January 2020, we reported 21 cases of Liposarcomas detected at the university hospital Mohamed VI of Marrakech's anatomical pathology department. The average age is 50, with a male majority. The average length of consultation was two years. The most revealing indication is tumefaction of the soft tissue. Most of the lesions were concentrated in the lower extremity. The preferred seat for these malignancies is the thigh. The X-ray was used on 21 patients, the echography was used on 16 patients, and the computed tomography was used on 15 patients. There have been 12 cases of magnetic resonance imaging and two cases of Doppler echography for two patients. The well differentiated Liposarcoma is the most common histologic sub-type (52%), followed by myxoid Liposarcoma (28%). 95% of patients had surgery, 90% of which was conservative, and 17 patients were referred for radiation supplementation, with only one instance receiving chemotherapy. In five cases, there was a loco regional recurrence, and one incidence of metastasis was discovered.
Cardiac Tamponade in Eisenmenger Syndrome: A Diagnosing Complexity: Case Report
Authors: Belkho W. , SAFI J. , Rachid L. , Chemaou L. , Malky Y. , Jamili M.El , Karimi S. El , Hattaoui M. El
Published: April 2022

Cardiac tamponade is a form of obstructive shock with clinical manifestations consistent with a low cardiac output and high central venous pressure. Features of a low cardiac output include low mean arterial pressure, cold peripheries and signs of poor end-organ perfusion. Characteristically, palpating the pulse reveals an apparent variation in pulse volume because of pulsus paradoxus. Jugular venous pressure is typically increased, with distended neck veins apparent. Sympathetic tone is increased in an attempt to compensate for the low cardiac output and manifests as tachycardia, diaphoresis, anxiety [1] and poor distal perfusion determining the need for emergent Pericardiocentesis. We report a case where an hemodynamically significant pericardial effusion with indication of pericardiocentesis had presented without classic signs of tamponade. It is an unusual and rare case of large pericardial effusion in the setting of Eisenmenger syndrome where only clinical signs as worsening hypoxia and cyanosis due to the right to left shunt was the warning sign of cardiac tamponade requiring pericardiocentesis.
Adverse Post-Vaccination Events (APEs) in Mali Hospital Following Astrazeneca COVID-19 Vaccine Immunization in Mali
Authors: Attaher Dicko Ousmane , Dembélé Guédiouma , Ibrahim Dramé boubacar Sidiki , Garan Dabo , Magara Samaké , Djénéba Diallo , Tamboura Awa , Farota Ibrahima , Diombana Kounandi , Soumaoro Mohamed Naremba
Published: April 2022

The health crisis caused by the coronavirus disease that emerged in late 2019 has not spared Mali, where it was identified as of March 25, 2020. In order to reduce the burden of the disease, preventing severe cases and deaths through the reduction of the virus circulation, Mali is considering, as a first step, the access to the COVID-19 vaccine to vulnerable people, in particular the socio-health personnel. The first vaccine used in our country was Astrazeneca, which, like all drugs, has side effects. Objectives: To identify adverse post-vaccine events (APEs) following Astrazeneca vaccination against COVID-19 and to establish their management. Methodology: This was a descriptive, cross-sectional study with retrospective data collection that took place from March 31, 2021 to October 24, 2021 including the two rounds of covid_19 vaccinations with Astrazeneca at the Mali Hospital level, the first round of which was launched from March 31, 2021 in Mali. It included all vaccinees with an adverse or unexpected sign, abnormal laboratory result, symptom, or illness following vaccination, whether or not causally related to the use of the vaccine. Results: During the 2 vaccination campaigns, we collected 20 cases of IPD out of a total of 312 recorded at the national level, i.e. a prevalence of 6.41%. The 56-65 age group was more represented in 5 cases (25%) with an average age of 42. Female sex was dominant with a sex ratio of 0.82, cases from commune VI were more reported, 7 cases (35%), the majority of the ILI appeared within 48 hours after vaccination, 15 cases (75%), hypertension was the most frequent medical history, 8 cases (40%). The most noted risk factor for coagulation was sedentary lifestyle, 9 cases (69.23%), heat at the injection site was the most frequent local reaction, 5 cases (38.46%), general aches and pains in the muscles were the most frequent systemic manifestations, 19 cases (13.48%). 11%), high fibrinogen levels 1 case (10%), high factors VIII and IX ea
Insulinoma: Diagnosis and Management on Two Observations
Authors: N Bilihi Bouyela , M Ben Lafqih , S Rafi , G El Mghari , N El Ansari
Published: April 2022

Insulinoma is an insulin-secreting pancreatic tumor responsible for hypoglycemia. It is a rare tumor that occurs in 1 to 4 persons / million in the population and represents 1 -2% of pancreatic tumors. The diagnosis is made by demonstrating, insulin secretion by measuring insulin levels and C-peptide in the presence of hypoglycemia and by demonstrating a pancreatic tumor by pancreatic CT and/or pancreatic MRI [5]. Surgical resection is the main modality for the treatment of insulinomas [1]. We report 2 observations of an insulinoma. A 47 year old patient, who consulted us for lipothymia associated with cold sweats and hunger, occurring preferably in the morning between 6 and 7 o’clock, The blood sugar level taken at the time of the malaise was 0.35 g/l. Assessment performed : Insulinemia ↑ : 701 pmol/l (18 -173), Peptide C↑: 2,35 pmol/ml ( 0,3- 1,4) in comparison with a hypoglycemia at 0,35 g/l. Abdominal MRI revealed a 16×16 mm nodule in the isthmus of the pancreas with poor vascularity compatible with an insulinoma. Observation 2: patient, 37 years, admitted for investigation and management of hypoglycemia ranging from 0.3 g/l occurring during physical activity. Workup performs: fasting test: peptide C↑: 3 ng/ml (1.1-1.47), insulinemia: 22.6 mUI/l (2.6- 24.9) vs. hypoglycemia 0.50 g/l, insulin/glycemia ratio=0.45 (normal <0.3), turner index:113 (normal <50). Normal abdominal CT scan completed by pancreatic MRI: pancreatic nodule in the isthmic region of 13*8 mm compatible with an insulinoma. Octreoscan: a hyperfixing focus on an isodense nodule of the head-neck junction of the pancreas measuring approximately 12*13 mm compatible with an insulinoma. Surgical management: enucleation. favorable evolution marked by the disappearance of hypoglycemia.
Dermatomyositis Triggered by Metastatic Subungueal Melanoma: A Case Report and Review of Literature
Authors: Taoufik H. , Boujguenna I. , Rais H. , Hocar O. , Amal S.
Published: April 2022

Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized predominantly by cutaneous and muscular abnormalities that can be associated with neoplasia. The association of dermatomyositis with nail melanoma is very rare, if not exceptional. We report the case of a paraneoplastic dermatomyositis due to an undiagnosed subungueal melanoma in a 70-year-old patient.
Coexistence of Large B Cell Non-Hodgkin’s Lymphoma and Lymph Node Tuberculosis: A Case Report and Review of Literature
Authors: Taoufik H. , Boujguenna I. , Rais H. , Hocar O. , Amal S.
Published: April 2022

Tuberculosis (TBK) and Non-Hodgkin’s Lymphoma (LNH) are two entities that threaten many lives around the world. Their coexistence in the same organ is rather rare and have received little attention [1]. We report the case of a Moroccan 45 year old man; who presented a swollen inguinal lympahadenopathy. He was previously diagnosed with lymphnode tuberculosis and treated with antituberculosis which he achieved 3 months before admission. In view of unresponsiveness to treatment and worsening of symptoms, a biopsy was conducted and the patient was diagnosed as diffuse Large B cells Non-Hodgkin’s Lymphoma.
Secretome – A new “Cappiler” for Compartement Syndrome
Authors: Tan Sukmawati Tansil , Firmansyah Yohanes , Destra Edwin
Published: April 2022

Compartment Syndrome, an orthopedic emergency, is a condition of increased perfusion pressure under closed tissue. Necrosis of the nerves and muscles, namely contracture of Volkmann and systemic complications such as acute renal failure, sepsis, ARDS, will result in compartment syndrome that is not properly treated. In children, doctors must be able to diagnose compartment syndrome in order to treat it in a timely manner. The effects of mismanagement will have an impact on the future of the child. A 5-year-old boy presented a case report with complaints of worsening wounds accompanied by loss of sensation. As the patient went to alternative medicine, the patient had to be amputated because of an error in the administration of therapy (The patient came to the “dukun tulang” for 5 months ago and received inappropriate treatment). Patients have signed an agreement to follow up on treatment by single-dose intracutaneous injection of Placental Wharton Jelly Stem Cell Secretom (SC-PWJSC). Intracutaneous injection of Secretom from Placental Wharton Jelly Stem Cell after administration of a single dose of 5cc (SC-PWJSC). The patient was advised to undergo amputation and the SC-PWJSC intracutaneous injection procedure was given to the patient. There was a significant improvement in the situation after 4 weeks of intervention.
Comparative Study of CBNAAT with Sputum Microscopy by Led Microscopy & Liquid Culture in Sputum Samples of Presumptive Pulmonary Tuberculosis
Authors: Kurdula Thanushree , M Sravan Kumar , C Sumalatha , B Phani Kumar , P Sunitha
Published: April 2022

Tuberculosis is a communicable disease & a leading cause of death from a single infectious agent (ranking above HIV /AIDS). Early diagnosis is important for early patient management and successful treatment. The present study was a prospective observational study done on 84 suspected Pulmonary Tuberculosis patients visiting Government Chest disease and TB hospital Warangal during the time period of December 2017 to July 2019 & were evaluated with different microbiological tests for further confirmation of pulmonary tuberculosis .Considering liquid culture as the gold standard tool for diagnosis of Tuberculosis, sensitivity , specificity, PPV, NPV of CBNAAT were 78.4%, 60.6%, 75%, 65% respectively and sensitivity, specificity, PPV, NPV of AFB smear were 80%, 47.5%, 39%, 85% respectively in the present study.
Clinical Profile of Tuberculosis Patients in a Tertiary Care Hospital of Bangladesh
Authors: Dr. Atiquzzaman Dr. Atiquzzaman , Hossain Dr. Mohammad Afjal , Bhuiyan Dr. Mohammed Shafiqul Islam , Yasmin Dr. Marufa , Sharmin Dr. Shayla , Bhattacharjee Professor Shekhar , Bhattacharjee Professor Swapna
Published: April 2022

Background: Despite noteworthy socio-economic development and advancement of medical science, till now tuberculosis (TB) is considered a major public health problem. Although TB is a curable disease, still millions of people suffer from TB every year and a number of them die from this infectious disease. Now a day, the prevalence and nature of tuberculosis are not in a consistent stage. We need more current information regarding this issue. Aim of the study: The aim of this study was to determine the clinical profile of tuberculosis patients. Methods: This study was a prospective, observational study which was conducted in the Department of Internal Medicine, US-Bangla Medical College, Narayanganj, Bangladesh during the period from January 2020 to December 2020. In total 73 diagnosed patients with tuberculosis, treated in this hospital were selected as the study subjects. Properly written consent was taken from all the participants before data collection. All data were processed, analyzed, and disseminated by using MS Office and SPSS version 23 as per need. Results: In this study, the majority of the participants were from the>40 years age group. One-third (34%) of participants were primary level educated whereas one-fourth (25%) were secondary level educated. The majority (56%) of the patients were found as ‘never smokers’. ‘Never drinker’ (Alcohol) was found 86%. Among the highest number of participants, pulmonary Koch’s was found which was in 42%. Among all the participants, cough and fever were found as two more frequent symptoms which were found in 96% and 86% patients respectively. As the final treatment outcome, we observed, 42% (n=31) patients were fully cured. Treatment was continued on 53% of patients and 4% (n=3) death cases were found. Conclusion: According to the findings of this study we can conclude that fever and cough are the two most frequent symptoms in tuberculosis patients. Although the death rate among TB patients is not alarming, the .........
Nosocomial Pneumopathies in Critical Care of the Military Hospital Mohammed V in Rabat-Morocco: Epidemiological, Clinical and Bacteriological Characteristics
Authors: Ayoub Azzouzi , Bouya Mohamed Said , Kondy Abdelghafour El , Touab Reda , Atmani Walid , Jaafari Abdelhamid , Balkhi Hicham
Published: April 2022

Nosocomial infections are defined as infections acquired in a care facility, which were neither incubating nor present when the patient was admitted. Nosocomial pneumopathies are a public health problem because they are responsible for significant morbidity and mortality with a considerable additional cost. They are frequent and serious in intensive care; they are the second most common acquired infections in a hospital setting. The diagnosis of nosocomial pneumopathy is based on a range of clinical, biological, radiological and bacteriological arguments. They cause problems of diagnostic, therapeutic and economic. The objective of this work consisted of an epidemiological study of the Nosocomial Pneumopathies (NP) and to evaluate the frequency, risk factors, antibiotic resistance of bacteria isolated, and factors of excess mortality. This prospective study focused on 65 patients hospitalized in the service of intensive care of the Mohammed V military instruction hospital in Rabat over a period of 6 month from 06/04/2017 to 06/10/2017, 52 patients had nosocomial pneumonia. The results of this work showed; that the germs isolated were essentially Gram-negative bacilli (77.5%), led by Acinetobacter Baumanii (37.8%), followed by Pseudomonas aeruginosa (18.9%), and klebsiella pneumoniae (9%). Gram positive cocci (7.2%), dominated by Staphylococcus aureus (7.2%). The polymicrobial character was found in 51% of cases. These isolated germs were multiresistant. During this study, there was a very significant morbidity of pneumonia by extending the duration of hospitalization in intensive care and the duration of ventilation. A very high risk of mortality has also been noted in patients infected in case of infection by non-fermenting germs.
Evaluation of Cutting Efficiency and Defects Influencing Surface Topography of Two Ni-Ti Rotary Instruments (An in Vitro Study)
Authors: Hanbola Mohamed M. A , Kataia Dr. Medhat A , Baz Dr. Alaa A EL
Published: April 2022

This study was designed to evaluate the cutting efficiency and defects influencing surface topography of HeroShaper and Revo-S NiTi rotary files.90mesiobuccal root canals of extracted permanent mandibular first molar, with fully developed apices and curvature ranging between 25-35 degree. Samples were divided into two groups according to the instrument used for canal preparation where group A prepared with HeroShaper and group B was prepared with Revo-S instruments. The cutting efficiency of both tested systems was evaluated by randomly selecting 10 samples from each group. The selected samples were weighted by a highly sensitive 5 digits scale, then each sample in both groups were instrumented according to the manufacturer’s recommendation, after preparation, each sample was re-weighted. The weight loss of each sample was being calculated. The data analysis showed statistically insignificant. Before preparation, each group of the files were subdivided into 3 groups, unused, after a single use, and after 9 uses. Both files showed no visible defect, and with SEM there was no statistically significant difference in unused and after single-use, while the Revo-S rotary instrument demonstrated the incidence of fracture after 9 uses. It could be concluded that the rotary Ni-Ti instruments should be examined prior to instrumentation using any type of magnification to check if there is a sign of deterioration.
Rethinking Robustness in Machine Learning: Use of Generative Adversarial Networks for Enhanced Robustness
Authors: Arslan Ayse
Published: April 2022

Machine learning (ML) is increasingly being used in real-world applications, so understanding the uncertainty and robustness of a model is necessary to ensure performance in practice. This paper explores approximations for robustness which can meaningfully explain the behavior of any black box model. Starting with a discussion on components of a robust model this paper offers some techniques based on the Generative Adversarial Network (GAN) approach to improve the robustness of a model. The study concludes that a clear understanding of robust models for ML allows improving information for practitioners, and helps to develop tools that assess the robustness of ML. Also, ML tools and libraries could benefit from a clear understanding on how information should be presented and how these tools are used.
Evaluation of the effectiveness of anti-inflammatory and antibacterial therapy of periodontal pathology
Authors: Chekina A. V. , Lomiashvili L. M. , Vetkova K. V.
Published: April 2022

Aim. To evaluate the effectiveness of anti-inflammatory and antimicrobial therapy in periodontal tissue pathology.

Materials and methods. 78 patients were examined. The results of treatment in 2 clinical groups were evaluated. Group 1 received traditional treatment; group 2 received therapy included local effects on the lymphatic system. The following methods were used in the study: clinical, radiological, bacterioscopic, cultural, immunological, expert assessments, mathematical statistics.

Results. A comparative analysis of the results of treatment of patients with periodontitis showed the effectiveness of local effects on the lymphatic system.

Conclusions. The data obtained allow us to conclude that in the clinical group of patients where local effects on the lymphatic system were used in the complex treatment of periodontitis, the effectiveness of therapy is higher, which is confirmed by the positive dynamics of clinical and laboratory indicators.
Comparative morphometric characteristics of the working surface of endodontic rotary nickel-titanium instruments after maximum cyclic loading
Authors: Dombrovskaya Yu. A. , Paderina T. O. , Benken K. A. , Lubskaya E. Yu. , Silin A. V.
Published: April 2022

Aim. Is the morphometric analysis of the working surfaces of endodontic rotating nickel-titanium instruments.

Materials and methods. The chemical composition and physical properties of the three types of endodontic rotating nickel-titanium F2 instruments have been analyzed: proptaper Universal (PTu, Dentsply, Maillefer, Ballaigues, Switzeland), Ultrataper (Eurofile, China) and Superfile (Eurofile, China) protapers. The evaluation of endodontic treatment of 75 endoblocks was also carried out.

Results. The research work shows that endodontic rotary instruments have both different chemical composition and heterogeneity of the alloy. The average comparable percentage of titanium and nickel in the studied alloy samples has been revealed. The quality of endodontic treatment of the endoblocks’ channels with various rotating nickel-titanium instruments is also comparable and meets the specified criteria.

Conclusion. The morphometric analysis has revealed a difference in the structure of the metal alloy of the F2 protapers, with a comparable content of nickel (46-52%) and titanium (38-41%). The content of pure nickel-titanium alloy along the periphery of the endodontic instrument in Universal protapers ensures high cutting ability of the faces. The obtained data on different resistance to cyclic loads should be taken into account in the endodontic treatment of multi-root teeth. The analysis of the structure of the nickel-titanium alloy indicates the predetermination of the development of the tool’s fracture with prolonged use and the need to take into account the cycles of the endodontic rotary tool.
Investigation of cyclic fatigue of rotary endodontic instruments
Authors: Khabadze Z. S. , Ismailov F. R.
Published: April 2022

Aim. To study the properties and resistance to cyclic loading of nickel-titanium files with a martensitic phase. The use of nickel-titanium instruments is an integral part of the endodontic treatment of root canals. During endodontic treatment, nickel-titanium instruments experience a huge load, which is manifested by fatigue of nickel-titanium instruments, in the form of a fracture.

Purpose. To determine the resistance of nickel-titanium files to mechanical, chemical and temperature stress.

Materials and methods. A nickel-titanium file with a martensitic S-flexi phase from Geosoft was selected as a study. Cyclic fatigue was determined using a simulation endodontic unit. Photo and video fixation was carried out as a calculation of the revolutions and breakage time of the tool in the process of determining cyclic fatigue. To assess changes in the structure of nickel-titanium instruments with a martensitic phase, electron scanning microscopy and determination of the elemental composition of the alloy were carried out.

Results. In the course of the study, tests were carried out to determine the cyclic load, close to the clinical reception. After a series of cyclic load detection tests, S-flexi files showed different resistance to cyclic load. The results of cyclic fatigue are summarized in Table 1.

Conclusion. High-quality and safe mechanical treatment of root canals is possible when using nickel-titanium S-flexi files. Due to the high resistance to mechanical, chemical and thermal stress.
Assessment of the antimicrobial efficacy of complex therapy for persistent periodontitis during endodontic retreatment
Authors: Manukian I. A. , Adamchik A. A. , Risovannyi S. I.
Published: April 2022

Aim. To evaluate the antimicrobial efficacy of endodontic retreatment of patients with destructive forms of persistent periodontitis using a combined approach to disinfection of the root canal system and a hyaluronic acid medication.

Materials and methods. Group № 1 – endodontic retreatment with root canal disinfection by Hypochloran-3; group № 2 – the same, but for root canal disinfection, first "Hypochloran-3" was applied, and then photodynamic therapy using a 662 nm diode laser and a photosensitizer "ELOFIT®"; group № 3 – in addition to the manipulations carried out in group № 2, of the "Revident" medication was injected twice in the projection of the apical part of the causative tooth. Antibacterial efficacy was assessed according to the results of microbiological studies of biological samples taken before and 2 weeks after endodontic retreatment. The identification of microorganism colonies was carried out by mass spectrometry.

Results. In patients with destructive forms of persistent periodontitis, both before and after root canals disinfection, Enterococcus faecalis ranked the first in terms of the frequency of detection in biological samples, Candida albicans the second, and Veillonella parvula the third. At the same time, before the treatment of root canals, the predominance (more than 80%) of polymicrobial associations with their participation was shown. After root canal treatment, the number of obtained microorganism isolates in groups 1-3 significantly decreased: by 60.0%, 74.3%, and 76.0%. Against this background, the share of strict anaerobes and microaerophiles in groups 1-3 decreased: by 60.6%, 81.3%, and 78.1%. The share of facultative anaerobes also significantly decreased by 59.7%, 79.7%, and 83.8%.

Conclusions. Endodontic retreatment of patients with destructive forms of chronic periodontitis using combined disinfection of root canals both without and in combination with a hyaluronic acid medication is accompanied by a statistically significant reduction in species diversity, associations, and content of periodontal pathogenic microbiota.
Keeping the periodontium youthful: truth or myth? Strategy and tactical approaches in periodontology based on preventive, predictive, personalized medicine
Authors: Belenova I. A. , Mitronin V. A. , Sudareva A. V. , Startseva S. V. , Vasilyeva M. S. , Oleinik E. A.
Published: April 2022

Relevance. The use of osteoplastic materials and hyaluronic acid in periodontology is extremely important for modern dentistry, since the predictive introduction of an osteoinductive drug and / or hyaluronic acid into the treatment protocol will allow simulating a state close to physiological, rejuvenating, and achieving the results of maximum restoration of periodontal structures.

Aim. To experimentally confirm the possibility of maintaining the physiological state and rejuvenating the periodontium using osteoplastic materials and / or hyaluronic acid.

Materials and methods. During the experiment, the dynamics of reparative osteogenesis in artificially reproduced defects of the jaw bones in rabbits was studied with the use of osteoplastic materials "Klipdent", "Bioplast-dent" or without the use of regeneration stimulants, as well as the morphogenesis of periodontal tissues when using hyaluronic acid. Results: the morphological studies carried out may indicate the acceleration of the regeneration processes in comparison with the normal course for 6-7 days.

Conclusions. It has been experimentally proven that the preservation and prolongation of periodontal youth is possible. We consider it appropriate and important in the conditions of modern dentistry, provided that the correct clinical strategy and tactical methods are chosen. In particular, the improvement of the procedure for open curettage of the periodontal pocket by predictively introducing an osteoinductive drug and / or hyaluronic acid into the treatment protocol will significantly increase the effectiveness of therapeutic measures and restore the periodontal condition close to physiological.
ОБ ОСОБЕННОСТЯХ ФОРМИРОВАНИЯ СИСТЕМЫ НАЦИОНАЛЬНЫХ МЕДИЦИНСКИХ ДАННЫХ
Authors: Чокаев Б.В. , Хасанова З.А.
Published: April 2022

Многие страны на протяжении последнего десятилетия занимаются активной цифровой трансформацией национальной системы здравоохранения. В большинстве стратегий целью развития цифровой медицины является интеграция разрозненных систем медицинских данных, приложений и нескольких видов программного обеспечения в единую систему. Преимуществом цифровой трансформации в целом и создания единой системы в частности является повышение эффективности, качества и доступности здравоохранения, выявление рисков для здоровья на более ранних стадиях и развитие профилактической и предиктивной медицины. На пути к формированию единой цифровой системы здравоохранения часто стоит несовместимость ее компонентов, другая сложность – безопасное использование персональных, часто конфиденциальных данных пациентов.
ПРЕИМУЩЕСТВА РОБОТИЗИРОВАННЫХ СИСТЕМ МАШИННОГО ЗРЕНИЯ
Authors: Мукушев А.Д. , Албогачиева Л.А.
Published: April 2022

Машинное зрение – это научное направление в области искусственного интеллекта, в частности робототехники, и связанные с ним технологии получения изображений объектов реального мира, их обработки и использования, полученных данных для решения разного рода прикладных задач без участия (полного или частичного) человека [1]. В данной статье рассмотрены преимущества роботизированных систем машинного зрения.
ОСНОВНЫЕ ШАГИ И МЕТОДЫ РАСПОЗНАВАНИЯ ЛИЦ
Authors: Завраев Ш.Х. , Хасухаджиев А.С.-А.
Published: April 2022

В данной статье рассматриваются основные шаги и методы распознавания лиц. Технология распознавания лиц имеет множество сфер применения, заметно упрощает и облегчает жизнь людей. Распознавание лиц в некоторых странах внедрено на каждом шагу, но своего пика в мире технология еще не достигла. Однако в ближайшем будущем, зная, с какой скоростью в современном мире внедряются новшества, технология займет свое место в каждой развитой стране.
L-ФУНКЦИИ ДИРИХЛЕ
Authors: Хамидова Т.А. , Исаев М.И.
Published: April 2022

L-функции Дирихле применяются для исследования распределения простых чисел в арифметических прогрессиях. L-функции Дирихле являются обобщением известной дзета-функции Римана.
ПРИМЕНЕНИЕ ПОЛИТИКИ ИНФОРМАЦИОННОЙ БЕЗОПАСНОСТИ ДЛЯ ЗАЩИТЫ КОНФИДЕНЦИАЛЬНЫХ ДАННЫХ БЕСПИЛОТНЫХ ЛЕТАТЕЛЬНЫХ АППАРАТОВ
Authors: Мартыненко А.А.
Published: April 2022

Предложены основные направления и концепции по обеспечению информационной безопасности в беспилотных авиационных комплексах в связи с актуальностью и перспективностью этого направления и большого собираемого объема информации с помощью дронов. Определена необходимость создания и применения комплекса определенных мер и правил, а именно политики информационной безопасности для защиты данных, в том числе с использованием криптографической защиты на основе квантового распределения ключа. Приведена схема шифрования КРК.
ФОРМИРОВАНИЕ ЦИФРОВЫХ КОМПЕТЕНЦИЙ В МАТЕМАТИЧЕСКОЙ СРЕДЕ
Authors: Магомерзаев Х.А. , Мухидинов М.Г. , Испагиева А.Д.
Published: April 2022

Современный этап развития общества по праву называют цифровым, тем самым обозначая актуализацию цифровых технологий представления данных в социальных моделях. Поэтому в условиях цифровизации общества в модели готовности специалиста необходимо актуализировать его цифровую составляющую. В данной статье акцентируется внимание на вопросах формирования цифровых компетенций в условиях информационной трансформации математического образования. Проведен анализ основных характеристик процесса математизации, выявлено содержание цифровой грамотности, как набор способностей, которые обеспечивают решение разнообразных задачи в области актуализации информационных технологий в процессе организации обучения дисциплинам математического цикла. В процессе этого исследования выделяются динамические способности будущего специалиста к развитию цифровых компетенций в условиях актуализации математической среды, определены принципы и методы его практической реализации.
МОДЕЛИРОВАНИЕ МУЛЬТИПЛЕКСИРОВАНИЯ ПОДНЕСУЩИХ НАЙКВИСТА ДЛЯ ОПТИЧЕСКОЙ СИСТЕМЫ ПЕРЕДАЧИ
Authors: Махмуд Хуссейн Ахмед Махмуд  , Румянцев К.Е.
Published: April 2022

В данной работе мы оцениваем использование двухприводных LiNb Mach-Zehnder модуляторов (DD-MZM) и сравниваем их с синфазными квадратурными (IQ)-модуляторами для генерации спектрально эффективных сигналов с двойной боковой полосой в формате модуляции QPSK из мультиплексирования поднесущих в форме импульса Найквиста (N-SCM). Исследовано влияние коэффициента свертывания импульса Найквиста на анализ когерентных оптических систем передачи. Скорость передачи данных 10 Гбит/с. Сигнал поднесущей Найквиста (скорость передачи данных 5 ГГц) модулируется двухприводным оптическим модулятором LiNb Mach-Zehnder с лазерным сигналом непрерывной волны длиной 1550 нм при входной мощности 10 дБм и ширине полосы пропускания 0,1 МГц. Моделирование оптической системы передачи основано на optisystem-14. Результат показывает, что импульсная форма Найквиста с коэффициентом свертывания, равным (α = 1), демонстрирует хорошую производительность системы.
Hukum Memberikan Daging Kurban kepada Orang Kafir (Studi Perbandingan antara Mazhab Syāfi’iyyah dan Ḥanābilah)
Authors: Ariesman Ariesman , Asri Asri , Ulum Bahrul
Published: April 2022

This study aims to find out and understand the law of giving sacrificial meat to  disbelievers (comparative study between the Shafi'iyyah and Ḥanābilah sect). This research is a qualitative descriptive type of research that focuses on the study of manuscripts and texts, and uses historical, juridical, normative, and philosophical approaches. The results of the study are as follows: the Syāfi’iyyah and Ḥanābilah sect have different opinions about the law of giving sacrificial meat to  disbelievers. Scholars from the Shafi'iyyah sect differ in this opinion. There are four opinions of them: the law is absolutely haram, haram if the sacrifice is an obligatory sacrifice, makrūh if the sacrifice is a voluntary sacrifice, and it is permissible to give sacrificial meat to non-Muslims as long as they are not muḥārib or infidels who are hostile to Islam. Meanwhile, the Ḥanābilah sect agrees that it is permissible to give sacrificial meat to a disbelievers, as long as the disbeliever is not a muḥārib, and the sacrifice is a voluntary sacrifice, not an obligatory sacrifice.
Kaidah al-Maṣlaḥah al-Mursalah dalam Hukum Islam dan Aktualisasinya terhadap Hak Atas Kekayaan Intelektual
Authors: Muhammad Yusram  , Iskandar Iskandar , Azwar Azwar , Najib Muhammad
Published: April 2022

This study aims to find out how the rules of al-maṣlaḥah al-mursalah in Islamic law and its actualization to Intellectual Property Rights (IPR). This research is a descriptive qualitative research (non-statistical) using library research methods and normative and philosophical juridical approaches. The results show that al-maṣlaḥah al-mursalah is something that is guarded in religion, where the law is built on it. Al-maṣlaḥah al-mursalah is the basis of justice and truth which is based on 'urf so that it becomes a secondary source of law. Al-maṣlaḥah al-mursalah is considered as a consideration for the humanitarian agenda in law, to maintain five main things; religion, soul, mind, lineage and property. The actualization of the rules of al-maṣlaḥah al-mursalah in IPR is viewed from two sides. First, in terms of ownership, the position is like property, namely property rights. The benefit to him is special which returns to the owner of the thing, then to the publisher. Second, in it there is a general benefit that returns to the whole community in the form of intellectual property benefits that have a major influence in various fields of life.
Tinjauan Wakaf Saham dalam Perspektif Hukum Islam
Authors: Aqbar Khaerul , Sulkifli Herman  , Muhammad Ichvan Mahmud
Published: April 2022

This study aims to determine the concept of stock waqf and its law in the view of Islamic law. This research uses descriptive qualitative research (non-statistical) by using library research method (library review) and using normative and juridical normative approaches. The research results found are as follows; first, stock waqf is the same waqf as other types of waqf, except that stock waqf is in the form of securities. Stock waqf has a similar concept to cash waqf. In this case, the waqif may waqf in the form of money and then nazir converts it in the form of stocks or the waqif can waqf directly the stocks he owns. The stocks waqf are stocks that comply with sharia principles. If the stocks to be donated are contrary to sharia, the stocks must first be sold or exchanged for halal stocks or stocks that comply with sharia principles; second, stock waqf is something new in waqf and has enormous benefits. When the stock waqf can really be managed properly, then it is able to improve the economy of Muslims. Therefore, stock waqf is permissible in the view of Islamic law.
DESCOMPOSICION DE CIANURO USANDO OZONO Y ÓXIDOS DE HIERRO
Authors: Garza Román Marleth Roxana , Carrillo Pedroza Francisco Raúl , Soria Aguilar Ma. de Jesús , Picazo Rodriguez Nallely Guadalupe
Published: April 2022

La cianuración ha sido por años el proceso más empleado para la extracción de oro, sin embargo, las soluciones resultantes afectan al medio ambiente ya que son tóxicas y complejas. Algunos de los procesos convencionales para la eliminación de cianuro es la oxidación, no obstante, esta puede resultar lenta. Debido a lo anterior el presente trabajo se enfoca en la eliminación de cianuro con procesos de oxidación avanzada catalítica como lo son el ozono y los óxidos de hierro. Las pruebas experimentales se desarrollaron bajo condiciones controladas a nivel laboratorio, usando óxidos de hierro como catalizadores. Los resultados mostraron que al agregar 1 g/L de óxidos de hierro, la concentración inicial de cianuro (250 ppm) se lograron disminuir a 11.9 ppm en un promedio de 11 minutos, por otro lado, en las pruebas que no usaron dichos óxidos a este tiempo se tenían 150 ppm de cianuro en la solución.
There Does Not Exist a Strongly Regular Graph with Parameters $(1911,270,105,27)$
Authors: Koolen Jack , Gebremichel Brhane
Published: April 2022

In this paper we show that there does not exist a strongly regular graph with parameters $(1911, 270, 105, 27)$.
The Challenge of drought in Costa Rica: A Preliminary Research with Economic Implications
Authors: Sosa Roxana Durán , , Castanho Rui Alexandre , Couto Gualter
Published: April 2022

In recent decades, Costa Rica has been characterized by the expansion of the forested frontier. More than half of the national territory has forest cover. Despite this, severe drought phenomena in the country compromise the stability of productive units and ecosystems. This article aims to contribute to the approach to drought control. The forest, precipitation, and land use relationship are presented as an alternative modeled by indigenous peoples. For this, an exhaustive review of bibliographic material, databases, and others was carried out. An interactive approach is made between the resources and natural phenomena and the forest linked to the philosophy of the native peoples. All this is part of the reflective analysis method. Contextually, the conclusions are: (i) Despite the expansion of the forest cover, the country has levels of precipitation that tend to decrease; amd (ii) Economic implications in agribusiness caused by droughts.
Determination of starch gelatinization degree in water-flour mixtures
Authors:   St. Petersburg branch Scientific Research Institute for the Baking Industry, Kukin M.Yu. , Kuznetsova L.I. ,   St. Petersburg branch Scientific Research Institute for the Baking Industry
Published: April 2022

Водно-мучные смеси со значительно клейстеризованным крахмалом (заварки) позволяют улучшить органолептические характеристики хлеба, особенно при использовании муки с пониженной сахарообразующей способностью. В связи с этим возникла необходимость различать водно-мучные смеси, подвергавшиеся или не подвергавшиеся нагреванию. В основу идентификации заварок было положено изменение свойств крахмала. В статье приведены результаты исследования поврежденного при заваривании крахмала, содержащегося в водно-мучных смесях, приготовленных с использованием ржаной муки, ферментированного солода и пророщенного зерна ржи. Установлено, что для водно-мучных смесей без крупных (более 3 мм) включений информация о вязкости позволяет судить о степени клейстеризации крахмала. Показано изменение динамической вязкости водно-мучных смесей в процессе их хранения. Для незаваренных полуфабрикатов при градиенте напряжения на срез 10 с-1 характерна динамическая вязкость менее 12 Па с, а для заваренных — более 30 Па с. Клейстеризованный крахмал образует с йодом синее окрашивание. Показано, что в некоторых случаях заваренные и незаваренные водно-мучные смеси идентично окрашиваются йодом, поэтому был разработан метод анализа, основанный на сравнении одной и той же водно-мучной смеси в изначальном состоянии и после повторного заваривания. При клейстеризации происходит набухание и разрушение зерен крахмала. Показано, что для водно-мучных смесей на основе ржаной муки оптимальной для визуальной оценки является кратность увеличения от 150х до 300х. На представленных фотографиях показано, что микроскопирование позволяет различать заваренные и незаваренные мучные полуфабрикаты.
Application of banana processing products in bread technology
Authors:   Russian State Agrarian University - Moscow Timiryazev Agricultural Academy, Novikova A.V. , Cabrera S. ,   Russian State Agrarian University - Moscow Timiryazev Agricultural Academy
Published: April 2022

В статье представлены комплексные исследования по изучению влияния продукта переработки плода банана – пюре из банана на органолептические и физико-химические показатели качества хлеба. Пюре из банана добавляли в качестве рецептурного компонента хлебобулочного изделия, его оптимальная дозировка составила 20 %, 25 %. Внесение исследуемого продукта способствовало увеличению удельного объема, пористости, улучшению реологических свойств мякиша изделий. Также при этом увеличивалось содержание белка, пищевых волокон, минеральных веществ, уменьшалось количество усвояемых углеводов, снижалась калорийность хлеба по сравнению с контролем. Установлено, что в соответствии с Приложением 2 к техническому регламенту Таможенного союза «Пищевая продукция в части ее маркировки» (ТР ТС 022/2011) изделия являются источником пищевых волокон. Применение в технологии хлеба продуктов переработки плодов бананов позволит расширить ассортимент хлебобулочных изделий, а их использование в рационе питания населения страны будет способствовать укреплению здоровья.
Birch Wood Modification Technology for Creating Neutron Shielding Materials
Authors:   Saint-Petersburg State Forest Technical University named after S.M. Kirov, Birman Alexei R. , Tambi Alexander A. ,   Arctic State Agrotechnological University, Ugryumov Sergey A. ,   Saint-Petersburg State Forest Technical University named after S.M. Kirov, Gilvanov Pavel R. ,   Military Space Academy named after A.F. Mozhaisky
Published: April 2022

The article considers a method for producing neutron shielding materials based on modified birch wood. It is known that shielding materials based on polyethylene with boron addition are widely used in the nuclear industry, medicine and the military-industrial complex to create protection against neutron radiation. Due to the high hydrogen content, their use makes it possible to protect objects from the effects of fast neutrons, and thermal neutrons are effectively contained due to the presence of boron atoms in the protective screens. Wood is also a hydrogen-containing material, therefore, it is of scientific and practical interest to create and study the properties of neutron shielding materials based on wood. The most expedient is the creation of neutron shielding materials from hardwood, which have a high specific density and, accordingly, a high content of hydrogen per unit volume. It is possible to increase the hydrogen content per unit volume of wood and, accordingly, to reduce the thickness of the protective layer due to the compaction of wood by the method of flat (singleaxis) pressing. The main condition for obtaining high-strength and form-resistant pressed wood is the preservation of its microstructure (without damage) during pressing. It has been theoretically found that the optimal pressing stage, at which the lowest percentage of microfractures in wood is observed, should not exceed 50 %. In the experimental part of the work, birch lumber was used for the production of an experimental neutron shielding material, radial sawn with a length of 200 mm, a width of 100 mm, and a thickness of 80 mm to obtain ready-made neutron shielding materials with a thickness of 40 mm, which is equivalent to a polyethylene shielding thickness of 26.8 mm. It is known that during flat pressing bursting forces occur in wood, which can lead to cracks, destruction of edges, buckling, delamination, and a decrease in the uniformity of the density distribution. The bursting force acts in the direction perpendicular to the action of the applied load. Therefore, in the manufacture of a neutron shielding composite material, it is necessary to use press molds (with side stops) that stop the impact of the bursting force. The design parameters of the press molds and pressing modes are determined taking into account the resistance caused by the friction forces of the wood against the side walls of the press mold. The design of a press mold that provides the production of a neutron shielding material of specified properties from wood is presented.