bluuebunny/crossref_metadata_2025 huggingface dataset:
Tawhid in Arabic Persfective: Semantic Studies
Authors: Syahril Mardhatillah , Salamuddin Salamuddin
Published: August 2023

This research was conducted to examine the meaning of the word Tawhid in the Arabic language perspective and understand in depth the nature of the word Tawhid in various semantic linguistic perspectives of the Arabic language. This research is a qualitative research with the method used, namely the descriptive method of analysis. The method is used in analyzing the word Tawhid in various perspectives, especially in the Arabic perspective. The meaning of Tawhid contained in several Arabic dictionaries is very varied. Researchers use semantic analysis derived from several dictionaries, sharaf books, and the perspectives of experts who can be analyzed that the word "توحيد" is isim masdar, and is called the word "توحيد" because the true meaning of the word tawhid is to discuss God. In Arabic, the word Allah is isim so it can be said, the word tawhid is given to Allah. Therefore, the science of tawhid is a science that includes a discussion of the dzat-dzat of Allah, the asthma of Allah and af'al Allah and also the science that believes in the existence of Allah.  The researchers concluded that the basic meaning of the word Tawhid is to worship God with the total belief that there is "There is no God but Allah".
Learning Organizational Leadership Strategy in Improving the Quality of Middle Level Education
Authors: Dacholfany Muhammad Ihsan , Samsudin Samsudin , Rais Rinovian , Leuwol Ferdinand Salomo , Wantu Hasyim Mahmud
Published: August 2023

The research is motivated by the need to form an appropriate leadership strategy to improve the quality of education by collaborating with all members including teachers, staff, students, and parents or guardians of students. This study aims to analyze and answer learning organization leadership strategies in improving the quality of secondary education. The research method used is a literature study based on articles, papers, books and other sources that support research with a qualitative approach. The results of this study indicate that improving the quality of secondary education requires strong leadership from school principals, good teacher performance, student and parent involvement in the education process, and attention to internal and external factors that affect education quality.
Performing Sere Bissu Maggiri as Character Education Content for the Bone Community
Authors: Bakhtiar Siti Rahmadani Nur , Malarsih Malarsih , Sugiarto Eko
Published: August 2023

Abstrak Pertunjukan Sere Bissu Maggiri merupakan pertunjukan tari tradisional berasal dari suku Bugis Bone yang teletak di Sulawesi Selatan. Pelaku kesenian dari pertunjukkan tersebut adalah Bissu merupakan laki-laki berpenampilan wanita dari Komunitas Bissu Bone. Tujuan penelitian ini mendeskipsikan nilai-nilai pendidikan karakter masyarakat Bone terefleksi dalam pertunjukan Sere Bissu Maggiri. Menggunakan metode kualitatif dengan desain penelitian fenomenalogi. Hasil penelitian menunjukkan Pendidikan Karakter pada masyarakat Bone dalam Pertunjukan Sere Bissu Maggiri terdapat nilai-nilai karakter terdapat Tuhan, terhadap diri sendiri dan terhadap sesama dari tiga nilai tersebut menjadi acuan dan pedoman bersikap sebagai masyarakat Bone dengan Bone kota beradat. Menjunjung tinggi nilai moral bersikap dan menghargai kesenian leluhur mempertahankan dan terus dilestarikan.

Kata Kunci: Pendidikan Karakter, Sere Bissu Maggiri, Bone

AbstractThe Sere Bissu Maggiri performance is a traditional dance performance originating from the Bugis Bone tribe located in South Sulawesi. The performers of the show are Bissu, men dressed as women from the Bissu Bone Community. The purpose of this study is to describe the character education values of the people of Bone as reflected in the Sere Bissu Maggiri performance. Using qualitative methods with a phenomenological research design The results of the study show that character education in the Bone community in the Sere Bissu Maggiri performance contains character values that include God, oneself, and others, with the three values becoming a reference and guideline for behaving as a Bone community in a civilized city. Upholding moral values, behaving and appreciating ancestral arts, and maintaining and continuing to be preserved

Keywords : Character Education, Sere Bissu Maggiri, Bone
Moral Messages in Kompang Traditional Music in Bengkalis Regency, Riau Province
Authors: Madani Anas , Sinaga Syahrul Syah , Utomo Udi
Published: August 2023

Musik kompang adalah musik tradisi Melayu yang mempedomani dari kitab barzanji berupa nyanyian atau puji-pujian terhadap kebesaran Allah SWT dan Nabi Muhammad SAW dan diiringi dengan instrumen kompang. Tujuan penelitian ini yaitu untuk menganalisis pesan moral dalam musik tradisional kompang di Kabupaten Bengkalis Provinsi Riau. Metode penelitian yang digunakan yaitu metode dengan jenis penelitian deskriptif kualitatif dengan menggunakan pendekatan interdisiplin. Hasil penelitian ini yaitu menunjukkan bahwa musik kompang merupakan salah satu sarana yang dapat dijadikan sebagai sarana komunikasi dalam mendidik melalui syair-syair Al-Barzanji yang dilantunkan, karena bermain musik kompang ini bukanlah suatu tuntutan tetapi merupakan suatu jalan insan berbudaya lebih melengkapi dirinya dengan nilai- nilai ajaran moral yang meliputi: (a) moral dalam hubungan manusia dengan Tuhan, (b) moral dalam hubungan manusia dengan manusia lain, (c) moral dalam hubungan manusia dengan alam, dan (d) moral dalam hubungan manusia dengan diri sendiri. Penelitian ini mengharapkan untuk kita semua sebagai audience dapat mengambil serta dapat mengaplikasikan nilai moral dalam kehidupan sehari-hari. Kata Kunci: Pesan Moral, Musik Tradisional Kompang.

Abstract Kompang music is traditional Malay music which is guided by the Barzanji book in the form of singing or praising the greatness of Allah SWT and the Prophet Muhammad SAW and accompanied by the Kompang instrument. The purpose of this research is to analyze the moral message in Kompang traditional music in Bengkalis Regency, Riau Province. The research method used is a qualitative descriptive research method using an interdisciplinary approach. The results of this study indicate that Kompang music is a means that can be used as a means of communication in educating through Al-Barzanji poems that are sung, because playing Kompang music is not a requirement but a way for a cultured human being to equip himself with moral values which include: (a) morals in human relations with God, (b) morals in human relations with other human beings, (c) morals in human relations with nature, and (d) morals in human relations with oneself. This research hopes that all of us as the audience can take and be able to apply moral values in everyday life.Keywords: Moral Message, Kompang Traditional Music.
Bismillah song aesthetics in Kompang Music in Meskom Village, Bengkalis District, Bengkalis Regency, Riau Province
Authors: Ananda Puteri Vebry , Sinaga Syahrul Syah , Utomo Udi
Published: August 2023

Kitab Al-Barzanji merupakan karya sastra Arab yang berisi cerita bernafaskan Islam berupa puji- pujian kepada Nabi Muhammad SAW beserta keluarganya dan puji-pujian kepada Allah SWT. Penelitian ini bertujuan untuk mengetahui estetika, makna dan bentuk lagu bismillah dalam musik kompang di Desa Meskom Kecamatan Bengkalis Kabupaten Bengkalis Provinsi Riau. Penelitian ini menggunakan metode penelitian deskriptif kualitatif dengan pendekatan interdisiplin yang menggunakan disiplin ilmu estetika dan semiotika. Disiplin ilmu estetika di gunakan untuk mengkaji keindahan pada lagu bismillah, sedangkan disiplin ilmu semiotika digunakan untuk mengkaji makna dan bentuk lagu bismillah. Hasil peneliti menjelaskan tentang estetika lagu bismillah dalam musik kompang di Desa Meskom Kabupaten Bengkalis Provinsi Riau, karena kesenian kompang ini memiliki keindahan dan makna yang mendalam pada setiap lirik lagu yang membuat beberapa dari kalangan masyarakat sangat menggemari kesenian tradisional kompang yang ada di Desa Meskom, sehingga kesenian Kompang ini dapat dinikmati dan di rasakan para penikmatnya.Kata kunci: estetika, al barzanji, kompang, bismillah.

Abstract Kitab Al-Barzanji is an Arabic literary work that contains stories with Islamic inspiration in the form of praises to the Prophet Muhammad and his family and praises to Allah SWT. This study aims to determine the aesthetics, meaning, and form of the bismillah song in Kompang music in Meskom Village, Bengkalis District, Bengkalis Regency, Riau Province. This study uses a qualitative descriptive research method with an interdisciplinary approach that uses the disciplines of aesthetics and semiotics. The discipline of aesthetics is used to study the beauty of the bismillah song, while the discipline of semiotics is used to study the meaning and form of the bismillah song. The researcher will examine the aesthetics of the bismillah song in Kompang music in Meskom Village, Bengkalis Regency, Riau Province, because this Kompang art has beauty and deep meaning in each song lyric, which makes some people really like the traditional Kompang art in Meskom Village, so Kompang arts can be enjoyed and felt by connoisseurs.
Teacher in K.H. Ahmad Dahlan's Perspective; A Study of Historical Reflection
Authors: Syahrul Syahrul , Saefuddin Didin , Bahruddin E. , Husaini Adian , Raharjo Arif Budi
Published: August 2023

Teachers became pioneers of change and awakened the intelligence of the native people in the public sphere in the early 20th century. The journey of the nation cannot be separated from the significant role of K.H. Ahmad Dahlan as a figure in Indonesian Islamic education. He established alternative education and prepared militant teacher cadres. This research aims to uncover K.H. Ahmad Dahlan's response to Dutch colonial education with the cadres of his teachers and his conception of the figure of a teacher. This study employs a qualitative approach with data sources from relevant literature such as books, journals, and newspapers or magazines, with a historical-philosophical approach and content analysis. The findings reveal that K.H. Ahmad responded to the need for teachers with a high spirit of struggle. This led him to establish Al-Qismul Arqa (Madrasah Mu’allimin). In K.H. Ahmad Dahlan's perspective, a teacher is a dedicated educator, progressive, and a good role model in the process of educating, teaching, guiding, and inspiring students to become individuals with noble character, devoted to Allah, possessing critical thinking skills, self-confidence, proficient in religious knowledge, broad-minded, and with a strong determination to serve Muhammadiyah, especially, and the Muslim community and society at large. They are ready to be arrows that disseminate the ideas of Islamic renewal amidst society.
Teachers' Strategies in Improving Students' Nationalism and Love for the Country in the Era of Globalization
Authors: Bawamenewi Adrianus , Harefa Anugerah Tatema , Lase Berkat Persada
Published: August 2023

This study aims to determine the teacher's strategy and challenges or obstacles in improving students' national insight and love for the country in the era of globalization. This research uses a qualitative method with a descriptive approach. The locations in this study were at Bunga Mawar Private Junior High School, BNKP Private Junior High School, Gunungsitoli Alo'oa State Junior High School 2 and BNKP AGIOS Nikolaus Private Junior High School, the four research locations chosen were in Gunungsitoli City, with Civics Teacher and student informants. The data collection techniques used are observation, interview and documentation techniques. Data analysis techniques in this study are data collection, data reduction, data presentation and data verification. From the results of the study, it was found that the Teacher's Strategy in Improving Students' Nationalism and Love for the Country in the Era of Globalization is to foster the value of nationalism in students through lessons, integrating nationalism and love for the country values to students in technology-based activities such as social media and the internet, implementing the values of Pancasila in the life of the school environment, inviting students to filter incoming information and culture in order to preserve traditional culture. Challenges in Improving Students' Nationalistic Insight and Love for the Country in the Era of Globalization, namely the development of technology can affect the mindset, attitude and action patterns of students in the nation and state, thus forgetting nationalistic insight. resulting in a conflict of values in students. Decreasing the moral quality of students, increasing social inequality, the emergence of fast-paced and instant traditions, difficult to organize and even against teachers. Schools have difficulty in restricting students from accessing social media and limited infrastructure to support students in participating in learning activities. Constraints in Improving Students' Nationalistic Insight and Love for the Country in the Era of Globalization lack of student awareness in applying the values or characters that have been taught, low parental concern for their children's education, changes in lifestyle that lead to unhealthy behavior, limited time owned by teachers to educate students in instilling moral values and love for the country.
A Narrative Inquiry on the Students’ Academic Writing Experience’s in Post Pandemic
Authors: Juliandini Shabrina , Sari Heni Novita
Published: August 2023

This study examines the impact of post-pandemic on undergraduate students' academic writing experiences in 2022-2023. It seeks to shed light on the challenges that students face in their academic writing. Narrative research is employed to understand the participants' lived and imagined experiences and the meaning they make of their own experiences through storytelling. The post-pandemic learning environment has changed the way students approach academic writing, with many struggling to adapt to the new online learning format. Solutions and support from parents, study partners, and the community can help overcome these challenges and foster creativity in students.
Meta-Analysis: The Effect of E-Learning-Based Mind Mapping on Students' Critical Thinking Skills
Authors: Luciana Occe , Santosa Tomi Apra , Rofi’i Agus , Taqiyuddin Taqiyuddin , Nasution Bachtiar
Published: August 2023

critical thinking skills. The type of research is meta-analysis research. The data sources in this meta-analysis research are 11 national and international journals that have been published from 2018-2023. The method of selecting data sources is the PRISMA method. The process of searching for data sources through Google Scholar, Eric and Proquest. The technique of collecting data sources is direct observation and documentation through the journal database. Data analysis is quantitative analysis by calculating the effect size value, standard error and average value (mean) with the help of the JSAP application. The results of this study indicate that the average effect size value is = 0.812 with high criteria. This finding explains that the e-learning-based mind mapping model has a significant effect on students' critical thinking skills. The e-learning-based mind mapping model fosters critical thinking skills so that it supports students' digital literacy in learning
Helicobacter delphinicola infection and the risk of gastric disease in common bottlenose dolphin
Authors: Segawa T , Ohno Y , Kurita M , Ishibashi T , Yoshioka M
Published: August 2023

Gastritis and gastric ulcers are well-recognized conditions in cetaceans; bacteria of the genus Helicobacter are considered the primary cause of these diseases. Dolphins have been shown to be susceptible to infection by at least 2 gastric species of Helicobacter, H. cetorum and H. delphinicola, both of which are closely related to the human pathogen H. pylori. In the present study, we evaluated the carriage rate and relationship to gastric disease of H. cetorum and H. delphinicola, based on a study population of 82 dolphins maintained at 21 facilities in Japan. Of these 82 dolphins, 79 (96.3%) and 45 (54.9%) were positive for H. cetorum and H. delphinicola, respectively; H. delphinicola infection was significantly associated with chronic gastric diseases (odds rate: 5.9; 95% CI: 2.1-16.9), but no such association was detected for H. cetorum. Of the 21 facilities, 20 (95%) and 11 (55%) housed H. cetorum- and H. delphinicola-positive dolphins, respectively, and our study suggested that the transmission between dolphins occurs quickly within pools. These findings indicate that methods will need to be established to prevent the transmission of Helicobacter infections within facilities housing dolphins.
Glial Cells in Alzheimer’s Disease
Authors:   , Verkerke Marie Louise
Published: August 2023

The human brain is responsible for information processing and functions at various levels, ranging from movement to language and creativity. It consists of neurons and glial cells, including astrocytes and microglia. Alzheimer's disease is the most common form of dementia and is characterized by protein accumulations (amyloid and Tau) in the brain and changes in glial cells. Most patients suffer from the late-onset form of the disease, for which aging and the E4 variant of the APOE gene are the main risk factors.

This thesis investigates the effect of APOE4 on astrocytes and microglia, using induced pluripotent stem cell (iPSC) models to mimic the brain in the lab. These iPSCs are derived from patients with Alzheimer’s Disease, making them highly suitable for studying disease processes. The iPSCs are differentiated into two types of models: (1) astrocytes isolated from other cells, and (2) brain organoids where astrocytes can interact with other brain cells. We found that APOE4 glia react differently than healthy APOE3 glia to two inflammatory stimuli, namely human serum and lipopolysaccharide. Additionally, significant differences were observed between the responses of APOE4 cells from patient A and patient B. This demonstrates that scientific research using iPSC models can reveal both general disease processes and patient-specific disease processes.

The findings in this thesis provide insight into disrupted brain processes caused by APOE4. Understanding these mechanisms could lead to future treatments aimed at restoring disrupted functions and addressing the root causes of the disease.
Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor
Authors: Rafcikova J , Novakova M , Stracina T
Published: August 2023

Contemporary society is characterized by rapid changes. Various epidemiological, political and economic crises represent a burden to mental health of nowadays population, which may at least partially explain the increasing incidence of mental disorders, including schizophrenia. Schizophrenia is associated with premature mortality by at least 13–15 years. The leading cause of premature mortality in schizophrenia patients is high incidence of cardiovascular diseases. The specific-cause mortality risk for cardiovascular diseases in schizophrenia patients is more than twice higher as compared to the general population. Several factors are discussed as the factor of cardiovascular diseases development. Intensive efforts to identify possible link between schizophrenia and cardiovascular diseases are made. It seems that sigma 1 receptor may represent such link. By modulation of the activity of several neurotransmitter systems, including dopamine, glutamate, and GABA, sigma 1 receptor might play a role in pathophysiology of schizophrenia. Moreover, significant roles of sigma 1 receptor in cardiovascular system have been repeatedly reported. The detailed role of sigma 1 receptor in both schizophrenia and cardiovascular disorders development however remains unclear. The article presents an overview of current knowledge about the association between schizophrenia and cardiovascular diseases and proposes possible explanations with special emphasis on the role of the sigma 1 receptor.
SINTESA TEORI KONSTRUKSI SOSIAL REALITAS DAN KONSTRUKSI SOSIAL MEDIA MASSA
Authors: Hadiwijaya Achmad Suhendra
Published: August 2023

The theory of the social construction of reality and the theory of the social construction of mass media are still partially discussed. Several previous pieces of research have not yet correlated, elaborated, or synthesized from the theoretical aspect. Even though much has been said about the social construction of reality, media consumers are heavily influenced by media "made" constructions. The research aims to synthesize the Bergerian theory of social reality construction (Berger and Luckmann) with the Bunginan theory of social reality construction (Burhan Bungin). The method used is a literature study. The results showed that the synthesis of the social construction theory of reality and the social construction of mass media reality produced a thesis understanding of an objective and subjective reality which was sufficiently understood through the social construction theory of mass media reality. This is considering the individual phenomenon which, in all durations of daily life, cannot be separated from the role of social media interaction. They externalize, objectify as well as internalize reality based on mass media references. In the hierarchy, the social construction theory of reality can be placed as a grand theory by considering genealogical aspects, while the social construction theory of mass media reality can be placed as a middle-rank theory. This is of course related to the more universal focus on social construction of reality.
DEFISIT KRITIS MEDIA MASSA: MENIMBANG KEBUTUHAN AKAN REGULASI DIRI MEDIA MASSA BERDASARKAN PEMIKIRAN JÃœRGEN HABERMAS
Authors: Kodoati Michael Carlos , Maida Serepina Tiur
Published: August 2023

Abstract:

This paper aims to observe the need for mass media self-regulation based on JÃ¼rgen Habermasâ€™s thoughts. Mass media have become a critical channel for public spaces since the birth of democracy. Habermas criticizes the contemporary mass media industry as no longer a critical channel because of the need for money to operate. The mass media are influenced by capitalism and political power. This causes a deficit in mass media. This research shows the importance of regulation such that the mass media does not fall under the domination of capitalism and political power. Media regulations need to be tightened, and ways need to be found so that independence is maintained in the adaptation of mass media commercialization. The need for money and the habit of political imagery in the public space cannot interfere with the performance of mass media as a channel for public criticism in a democracy.

Abstrak:

Tulisan ini disusun untuk melihat kebutuhan akan regulasi diri media massa berdasarkan pemikiran JÃ¼rgen Habermas. Media massa menjadi saluran kritis ruang publik sejak kelahiran demokrasi. Habermas mengkritik industri media massa kontemporer tidak lagi sebagai saluran kritis karena kebutuhannya akan uang untuk beroperasi. Media massa terpengaruh kapitalisme dan kekuasaan politik. Ini menyebabkan defisit kritis media massa. Penelitian ini hendak menunjukkan pentingnya mengatur agar media massa tidak jatuh pada dominasi kapitalisme dan kekuasaan politik. Regulasi media perlu dikencangkan dan perlu mencari cara agar independensi tetap terjaga dalam adaptasi komersialisasi media massa. Kebutuhan akan uang dan kebiasaan pencitraan politik dalam ruang publik tidak boleh mengganggu kinerja media massa sebagai saluran ruang kritik publik dalam demokrasi.
PERGESERAN MAKNA TRADISI BAJAPUIK ADAT PERNIKAHAN PARIAMAN
Authors: Rahayu Riza Gusti
Published: August 2023

Tradisi pernikahan merupakan sebuah ritual yang melekat pada masyarakat, proses dari sebuah tradisi memiliki makna tersendiri bagi pelakunya. Tradisi Bajapuik memiliki makna kekeluargaan dan penghargaan sehingga masyarakat Pariaman hingga kini tetap berupaya untuk melestarikannya. Namun perkembangan zaman dan pergeseran pada masyarakat tentunya menjadi salah satu penyebab terjadinya pergeseran makna terutama pada masyarakat perantauan. Proses pergeseran makna bagi masyarakat pariaman urban terjadi melalui komunikasi antarbudaya ditengah masyarakat. Tujuan penelitian ini adalah mendeskripsikan pergeseran makna tradisi bajapuik yang dilakukan oleh perantau pariaman di perkotaan. Jenis penelitian yang digunakan adalah penelitian kualitatif melalui wawancara, observasi dan dokumentasi sebagai metode pengumpulan data. Hasil penelitian ini menunjukan bahwa terjadi pergeseran makna tradisi bajapuik bagi perantau perkotaan dikarenakan keadaan individu modern masyarakat terlibat dalam politik identitas dimana masyarakat cenderung mencari formasi identitas baru. Terdapat pergeseran makna Bajapuik, simbol Bajapuik dan prosesi tradisi Bajapuik dalam lingkungan sosial perantau dan dalam mengekspresikan identitas etnis Minang karena kesadaran individu untuk mempertahankan tradisi Bajapuik yang konvensional.

Kata Kunci : Makna, Tradisi Bajapuik, Adat Pernikahan Pariaman
Híd a szakadék felett : A lipidcsökkentő kezelés ajánlásai és a valósága
Authors: Reiber István , Mező Izabella
Published: August 2023

2023-ban evidenciaként kell elfogadunk azt a tényt, hogy az emelkedett LDL-C okozó rizikótényezője az atheroscleroticus érbetegségeknek és a következményként fellépő érkatasztrófáknak (myocardialis infarktus, stroke, perifériás érelzáródás). Intenzív lipidterápiával, azaz intenzív dózisú statin (20–40 mg rosuvastatin vagy 40–80 mg atorvastatin) és ezetimib kombinációjának alkalmazásával 50% feletti mértékben csökkenthető az LDL-C-szint, és így a kezeltek nagy részénél elérhetőek lennének a hazai és a nemzetközi ajánlásokban szereplő LDL-C-célértékek. Ugyan - akkor jól ismertek azok az adatok, hogy a dyslipidaemiás betegeknél nagyon rossz a lipidcsökkentő gyógyszerek vonatkozásában a terápiás fegyelem (gyenge adherencia, perzisztencia). A dyslipidaemiás betegek terápiás együttműködésének javításához a kezelőorvosnak határozott meggyőződéssel kell képviselni, hogy az LDL-C hatásos csökkentésével megelőzhetőek az érkatasztrófák és azok ismétlődése. A rendelkezésre álló gyógyszerek biztonságosak, hatásosak. A betegeket individuálisan megválasztott kommunikációval meg kell győzni, hogy az emelkedett LDL-C-szint idő előtti érkárosodáshoz vezet, és az LDL-C hatásos csökkentésével a már kialakult ér - elváltozások visszafordíthatóak, javíthatók. A betegek rendszeres ellenőrzésével a szükséges terápiás együttműködést hosszú távon fenn kell tartani.
El burnout en los profesionales de la salud del Centro Clínico Quirúrgico Ambulatorio Hospital del Día Central Loja durante la pandemia: factores sociodemográficos y laborales
Authors:   Universidad Regional Autónoma de los Andes, Rea Chela Jessica Karolina , Morillo Cano Julio Rodrigo ,   Universidad Regional Autónoma de los Andes, Flores Pilco Diego Armando ,   Universidad Regional Autónoma de los Andes
Published: August 2023

La investigación tiene como objetivo determinar la presencia del síndrome de burnout (SB) en el personal de salud del Centro Clínico Quirúrgico Ambulatorio del Hospital del Día Central Loja, durante la pandemia COVID-19, y correlacionar sus niveles con variables sociodemográficas y laborales. El SB es causado por el estrés laboral crónico y fue declarado por la OMS como un factor de riesgo laboral que empeoró durante la pandemia. A través de la aplicación de metodologías de tipo cuantitativo, transversal y diseño descriptivo, empleando formularios en línea de Google Forms, para los datos sociodemográficos y el Cuestionario de Maslach Burnout Inventory, para el estudio emocional y rendimiento laboral, a 100 profesionales de la salud entre médicos, enfermeras y auxiliares de enfermería, del Centro Clínico Quirúrgico Hospital del día Central Loja, que trabajaron durante la pandemia: Los resultados indicaron que un 51 % de los profesionales de la salud sufren del SB y que existe una relación positiva baja entre la edad y el cansancio emocional y la despersonalización. Además, se encontró una correlación fuerte entre el estado civil y el cansancio emocional y moderada con la despersonalización. Por otro lado, el horario y la jornada laboral se relacionaron de forma moderada con el cansancio emocional y la realización personal. En conclusión, el estudio revela la presencia del SB en una significativa cantidad de profesionales de la salud en el Centro Clínico Quirúrgico de Loja.
Comportamiento de probetas de madera de tres especies forestales frente al ataque de Lenzites betulina (L.) Fr., 1838 en condiciones de laboratorio
Authors:   Universidad Estatal del Sur de Manabí, Cabrera Verdesoto César Alberto , Tapia Zúñiga Mónica Virginia ,   Universidad Estatal del Sur de Manabí, Parrales Vaca Bernabé Fabián ,   Investigador independiente, Jiménez González Alfredo ,   Universidad Estatal del Sur de Manabí, Cali Ligua Valeria Lissette ,   Investigador independiente
Published: August 2023

La presente investigación tuvo como objetivo evaluar el comportamiento de tres especies forestales del bosque seco tropical Prosopis pallida (Humb. & Bonpl. ex Willd.) Kunth, Cordia alliodora (Ruiz & Pav.) Oken 1841, y Cedrela odorata L. 1753 frente al ataque del hongo xilófago Lenzites betulina (L.) Fr., 1838 a través de una prueba acelerada en laboratorio. El método experimental aplicado fue un diseño de bloques completamente al azar, con un 5% de confiabilidad, apoyado además por los métodos inductivo, deductivo y estadístico, este diseño estuvo compuesto por tres tratamientos, tres repeticiones y 90 unidades experimentales. Los factores en estudios fueron: la resistencia de las tres especies al ataque de Lenzites betulina (L.) Fr., 1838, en una prueba acelerada en laboratorio; grado de afectación del hongo xilófago, en las especies forestales en estudio. De los resultados obtenidos se concluye que la especie algarrobo se presenta como la especie de menor afectación, en los estados estabilizados y natural; no así el cedro que está dentro de los parámetros de muy baja durabilidad siendo recomendable en esta especie un tratamiento de conservación a fin de evitar su pudrición por hongos en el caso de su uso en áreas de abundante humedad, concordando con la hipótesis planteada.
Evaluación de los patrones motrices básicos en los niños escolarizados con Síndrome de Down
Authors:   Universidad Técnica de Babahoyo, Naranjo Vera Jonathan Jacinto , Luperón Terry Juan Miguel ,   Universidad Técnica de Babahoyo, López Bustamante Golda Geovanna ,   Universidad Técnica de Babahoyo
Published: August 2023

La presente investigación tuvo como objetivo evaluar el nivel de desarrollo de los patrones motrices básicos en los niños escolarizados con Síndrome de Down de la Escuela Especial 3 de Diciembre, del Cantón Vinces, Ecuador. Se trabajó con una muestra de tipo intencional a través de un muestreo no probabilístico comprendida por diez niños/as con Síndrome de Down (7 varones y 3 mujeres). Se aplicó el instrumento de evaluación neuromotriz “EVANM” para la evaluación de ocho patrones motrices básicos (PMB): arrastre, gateo, marcha, triscado, carrera, tono muscular, equilibrio y control postural. Los niños/as escolarizados con Síndrome de Down de la Escuela Especial 3 de Diciembre no han adquirido los PMB de triscado y equilibrio evidenciando movimientos torpes y descoordinados; el 57% de los niños y niñas con Síndrome de Down aún no adquieren el patrón cruzado del arrastre condicionados con una deficiencia en el tono muscular. Sin embargo, se tuvo que; los PMB como el gateo (57%), marcha (57%), carrera (57%) y el control postural (71%) se encuentran en proceso de desarrollo. Los déficits presentados en los niños/as evaluados con síndrome de Down no solo influyen directamente en el desarrollo de la motricidad sino también en las esferas de aprendizajes relacionadas a la escritura, lectura, comunicación, propiocepción, entre otros aspectos relevantes.
Análisis financiero para la implementación de una microempresa procesadora sustituto de café utilizando raíz de Taraxacum officinale y Vicia faba
Authors:   Universidad Nacional de Chimborazo, Villegas Núñez Darwin Fabián , Baño Ayala Darío Javier ,   Universidad Nacional de Chimborazo, Moposita Vásquez Diego David ,   Universidad Nacional de Chimborazo, Rivera Castillo María Fernanda ,   Universidad Nacional de Chimborazo
Published: August 2023

Actualmente en la ciudad de Riobamba existen pocas microempresas generadoras de empleo, ante esta problemática y conscientes de la importancia de generar nuevas fuentes de trabajo, se planteó: realizar un estudio de factibilidad conformado por estudio de mercado, técnico y financiero, en donde se aplicó una metodología basada en métodos: analíticos, deductivos e inductivos, técnicas como observación directa y encuestas aplicadas en habitantes de varias parroquias de Riobamba. En el estudio de mercado se logró determinar el tamaño de la oferta-demanda, mostrando un plan de comercialización donde se estableció las 4p’s. En el estudio técnico se enfatizó la ubicación de la planta, al igual que la descripción de la maquinaria, equipos y herramientas. Por consiguiente, se estableció una inversión de $9.093,00, con un capital propio del 10% y el capital externo del 90%, obtenido a través de un crédito con interés del 10.21% anual. De igual manera se estableció la estructura de los costos, el estado de pérdidas y ganancias, flujo de caja y punto de equilibrio. En la Evaluación Financiera del proyecto, se obtuvo un VAN de $6.086,09; la TIR de 79.64%; la Relación Beneficio-Costo es 0,67 centavos; el periodo de Recuperación de Capital se dará en 2 años, 7 meses y 12 días, por ende, se determina la factibilidad de la implementación de la microempresa.
Higiene doméstica y enteropatógenos en escolares de la provincia de Santa Elena, Ecuador 2019
Authors:   Universidad Estatal Península de Santa Elena, Suárez Yagual Elsie Zoraida , Tumbaco Villao Anallely Elizabeth ,   Universidad Estatal Península de Santa Elena, Salinas Salinas Sonnia Del Carmen ,   Universidad Estatal Península de Santa Elena
Published: August 2023

La higiene doméstica es un factor predisponente a la infección por microorganismos causantes de diarreas en escolares. El objetivo fue caracterizar determinantes de salud relacionados con enteropatógenos. El estudio fue descriptivo, retrospectivo y transversal en el período de mayo a diciembre del 2019, con un universo de 120 binomios cuidadores/escolares, de tres comunidades rurales de Santa Elena; muestreo probabilístico extraído de la base de datos secundarios de los laboratorios de Manglaralto y Monteverde del Ministerio de Salud Pública, se utilizó Programa Excel SPSS 23.0 y prueba de Chi-Cuadrado de Pearson, nivel de significación p<0,005, se aplicó encuesta estructurada de recolección de datos. Resultados: asociación estadística y significativa entre la aparición de enteropatógenos y el origen (p=0,000); presencia de animales domésticos (p= 0,000); lavado de manos de escolares antes de comer (p=0,004) y después de defecar (p=0,003). Se concluye, que la higiene doméstica, fue determinante en la presencia de enteropatógenos y diarreas en escolares de las comunidades examinadas, sumados a la falta de conocimientos del cuidador/a en el mecanismo de transmisión, que justifica el desarrollo y la implementación de estrategias educativas de intervención en promoción y prevención de salud.
Gestión de residuos hospitalarios
Authors:   Pontificia Universidad Católica del Ecuador, Vinueza Villarés Viviana Vanessa , Vasco Yánez Samantha Analía ,   Pontificia Universidad Católica del Ecuador
Published: August 2023

La gestión de residuos hospitalarios, también conocidos como desechos o residuos sanitarios, pueden ser peligrosos debido a su potencial de contener agentes infecciosos, sustancias químicas peligrosas y materiales biológicos. Los residuos hospitalarios requieren un tratamiento adecuado antes de su eliminación final. Dependiendo del tipo de residuo, pueden ser sometidos a procesos de esterilización, desinfección, incineración, tratamiento químico o tratamiento biológico. El objetivo de este trabajo es una revisión de los protocolos de gestión de estos residuos para minimizar el riesgo a la salud humana y el medio ambiente, que incluyen procesos de recogida selectiva, almacenamiento adecuado, transporte, y tratamiento final. Se ha realizado una revisión de la legislación en distintos países, el grado a aplicación y seguridad. Uno de los aspectos clave es la capacitación y concienciación del personal sanitario, los trabajadores de limpieza y todos los involucrados en la gestión de residuos hospitalarios sobre las prácticas seguras de manejo y eliminación de residuos. La concienciación sobre la importancia de una gestión adecuada de los residuos también es fundamental para garantizar su correcta segregación y manejo.
Detection of various fusion genes by one-step RT-PCR and the association with clinicopathological features in 242 cases of soft tissue tumor
Authors: Song Lingxie , Zhang Ying , Wang Yuanyuan , Xia Qingxin , Guo Dandan , Cao Jiachen , Xin Xin , Cheng Haoyue , Liu Chunxia , Jia Xingyuan , Li Feng
Published: August 2023

Introduction: Over the past decades, an increasing number of chromosomal translocations have been found in different STSs, which not only has value for clinical diagnosis but also suggests the pathogenesis of STS. Fusion genes can be detected by FISH, RT-PCR, and next-generation sequencing. One-step RT-PCR is a convenient method to detect fusion genes with higher sensitivity and lower cost.

Method: In this study, 242 cases of soft tissue tumors were included, which were detected by one-step RT-PCR in multicenter with seven types of tumors: rhabdomyosarcoma (RMS), peripheral primitive neuroectodermal tumor (pPNET), synovial sarcoma (SS), myxoid liposarcomas (MLPS), alveolar soft part sarcoma (ASPS), dermatofibrosarcoma protuberans (DFSP), and soft tissue angiofibroma (AFST). 18 cases detected by one-step RT-PCR were further tested by FISH. One case with novel fusion gene detected by RNA-sequencing was further validated by one-step RT-PCR.

Results: The total positive rate of fusion genes was 60% (133/213) in the 242 samples detected by one-step RT-PCR, in which 29 samples could not be evaluated because of poor RNA quality. The positive rate of PAX3–FOXO1 was 88.6% (31/35) in alveolar rhabdomyosarcoma, EWSR1–FLI1 was 63% (17/27) in pPNET, SYT–SSX was 95.4% in SS (62/65), ASPSCR1–TFE3 was 100% in ASPS (10/10), FUS–DDIT3 was 80% in MLPS (4/5), and COL1A1–PDGFB was 66.7% in DFSP (8/12). For clinicopathological parameters, fusion gene status was correlated with age and location in 213 cases. The PAX3–FOXO1 fusion gene status was correlated with lymph node metastasis and distant metastasis in RMS. Furthermore, RMS patients with positive PAX3–FOXO1 fusion gene had a significantly shorter overall survival time than those patients with the negative fusion gene. Among them, the FISH result of 18 cases was concordant with one-step RT-PCR. As detected as the most common fusion types of AHRR–NCOA2 in one case of AFST were detected as negative by one-step RT-PCR. RNA-sequencing was used to determine the fusion genes, and a novel fusion gene PTCH1–PLAG1 was found. Moreover, the fusion gene was confirmed by one-step RT-PCR.

Conclusion: Our study indicates that one-step RT-PCR displays a reliable tool to detect fusion genes with the advantage of high accuracy and low cost. Moreover, it is a great tool to identify novel fusion genes. Overall, it provides useful information for molecular pathological diagnosis and improves the diagnosis rate of STSs.
Dynamics of chromosome organization in a minimal bacterial cell
Authors: Gilbert Benjamin R. , Thornburg Zane R. , Brier Troy A. , Stevens Jan A. , Grünewald Fabian , Stone John E. , Marrink Siewert J. , Luthey-Schulten Zaida
Published: August 2023

Computational models of cells cannot be considered complete unless they include the most fundamental process of life, the replication and inheritance of genetic material. By creating a computational framework to model systems of replicating bacterial chromosomes as polymers at 10 bp resolution with Brownian dynamics, we investigate changes in chromosome organization during replication and extend the applicability of an existing whole-cell model (WCM) for a genetically minimal bacterium, JCVI-syn3A, to the entire cell-cycle. To achieve cell-scale chromosome structures that are realistic, we model the chromosome as a self-avoiding homopolymer with bending and torsional stiffnesses that capture the essential mechanical properties of dsDNA in Syn3A. In addition, the conformations of the circular DNA must avoid overlapping with ribosomes identitied in cryo-electron tomograms. While Syn3A lacks the complex regulatory systems known to orchestrate chromosome segregation in other bacteria, its minimized genome retains essential loop-extruding structural maintenance of chromosomes (SMC) protein complexes (SMC-scpAB) and topoisomerases. Through implementing the effects of these proteins in our simulations of replicating chromosomes, we find that they alone are sufficient for simultaneous chromosome segregation across all generations within nested theta structures. This supports previous studies suggesting loop-extrusion serves as a near-universal mechanism for chromosome organization within bacterial and eukaryotic cells. Furthermore, we analyze ribosome diffusion under the influence of the chromosome and calculate in silico chromosome contact maps that capture inter-daughter interactions. Finally, we present a methodology to map the polymer model of the chromosome to a Martini coarse-grained representation to prepare molecular dynamics models of entire Syn3A cells, which serves as an ultimate means of validation for cell states predicted by the WCM.
Mathematics education research on algebra over the last two decades: quo vadis?
Authors: Veith Joaquin Marc , Beste Meeri-Liisa , Kindervater Marco , Krause Michel , Straulino Michael , Greinert Franziska , Bitzenbauer Philipp
Published: August 2023

Algebra is a crucial component of mathematics education as it introduces learners to the mathematical world of modeling relationships and handling abstract quantities. The increasing volume of scholarly work in the field has been analyzed qualitatively in numerous systematic reviews—a quantitative breakdown of the field, however, remains a desideratum to date. With this study we contribute to closing this gap by reporting on the results of a bibliometric analysis. We retrieved data from Scopus and Web of Science databases and analyzed 1,825 articles published between 2003 and 2022. On the one hand, we provide insight into the current state of algebra education from primary up to tertiary education by describing the scientific production and its bibliographic topography. On the other hand, we analyzed the data to identify trends and future directions. The results of our study indicate, among other aspects, that APOS Theory and Realistic Mathematics Education are emerging themes in the field that have great potential to shape future research.
Causal association of NAFLD with osteoporosis, fracture and falling risk: a bidirectional Mendelian randomization study
Authors: Cui Aiyong , Xiao Peilun , Fan Zhiqiang , Lei Jinlai , Han Shuang , Zhang Danlong , Wei Xing , Wang Pengfei , Zhuang Yan
Published: August 2023

Introduction

The causal association between non-alcoholic fatty liver disease (NAFLD) and osteoporosis remains controversial in previous epidemiological studies. We employed a bidirectional two-sample Mendelian analysis to explore the causal relationship between NAFLD and osteoporosis.

Method

The NAFLD instrumental variables (IVs) were obtained from a large Genome-wide association study (GWAS) meta-analysis dataset of European descent. Two-sample Mendelian randomization (MR) analyses were used to estimate the causal effect of NAFLD on osteoporosis, fracture, and fall. Reverse Mendelian randomization analysis was conducted to estimate the causal effect of osteoporosis on NAFLD. The inverse-variance weighted (IVW) method was the primary analysis in this analysis. We used the MR-Egger method to determine horizontal pleiotropic. The heterogeneity effect of IVs was detected by MR-Egger and IVW analyses.

Results

Five SNPs (rs2980854, rs429358, rs1040196, rs738409, and rs5764430) were chosen as IVs for NAFLD. In forward MR analysis, the IVW-random effect indicated the causal effect of NAFLD on osteoporosis (OR= 1.0021, 95% CI: 1.0006-1.0037, P= 0.007) but not on fracture (OR= 1.0016, 95% CI: 0.998-1.0053, P= 0.389) and fall (OR= 0.9912, 95% CI: 0.9412-1.0440, P= 0.740). Furthermore, the reverse Mendelian randomization did not support a causal effect of osteoporosis on NAFLD (OR= 1.0002, 95% CI: 0.9997-1.0007, P= 0.231). No horizontal pleiotropic was detected in all MR analyses.

Conclusions

The results of this study indicate a causal association between NAFLD and osteoporosis. NAFLD patients have a higher risk of osteoporosis but not fracture and falling risk. In addition, our results do not support a causal effect of osteoporosis on NAFLD.
State-of-health estimation for lithium-ion batteries based on Bi-LSTM-AM and LLE feature extraction
Authors: Wang Wentao , Yang Gaoyuan , Li Muxi , Yan Zuoyi , Zhang Lisheng , Yu Hanqing , Yang Kaiyi , Jiang Pengchang , Hua Wei , Zhang Yong , Zou Bosong , Yang Kai
Published: August 2023

With the increasing demands for battery safety management, data-driven method becomes a promising solution for highly accurate battery state of health (SOH) estimation. However, the data-driven method faces problems of poor interpretability and high dependence on input features. This paper proposes a SOH estimation method that integrates data-driven model and signal analysis method. Specifically, the differential thermal voltammetry (DTV) analysis method is used to analyze aging characteristics to obtain features strongly related to battery aging and solve the problem of poor interpretability of data-driven methods. The use of local linear embedding method (LLE) for feature extraction has improved model efficiency. A data-driven model is constructed with the Bi-directional long short-term memory (Bi-LSTM) as the core, and the attention mechanism (AM) is added to focus on important parts of the sequence to further improve the accuracy of the model. The proposed method is validated based on the Oxford battery degradation dataset, and the results show that the proposed method achieves high accuracy and strong robustness in SOH estimation with a root mean square error (RMSE) maintained at about 0.4%. This method has the potential to be employed on cloud platforms or end-cloud collaboration systems for online implementation.