bluuebunny/crossref_metadata_2025 huggingface dataset:
Established Statin Use Reduces Mortality From Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis
Authors: Fitzgerald Emma , Duquette Laurel , Williams Matthew
Published: April 2023

Background: Statin therapy (ST) has been associated with improved outcomes from sepsis. Our objective was to systematically review the association between established ST and outcomes of patients with community-acquired pneumonia (CAP) that is severe enough to require hospitalisation.
Methods: Two meta-analyses were conducted following a search of articles published before 31st January 2013. After exclusions, seven studies were included to assess the effects of statins on 30-day mortality from CAP, and eight studies were included to assess the effects of statins on the development of CAP. Endpoints were a reduction in the risk of 30-day mortality or risk of developing CAP.
Results: A reduction in the risk of 30-day mortality from CAP was identified in patients established on ST (pooled odds ratio [OR]: 0.70, 95% confidence interval [CI]: 0.65-0.76; adjusted OR: 0.58, 95% CI: 0.47-0.69). The pooled OR for risk of developing CAP in patients with and without established ST was 1.01 (95% CI: 0.98-1.04).
Conclusion: There appears to be weak evidence to suggest a potential benefit of established ST. It is associated with a reduced risk of 30-day mortality in patients subsequently hospitalised with CAP. Further evidence is required, but ST could be considered as a means of reducing the risk of mortality from pneumonia.
The Efficacy and Safety of Flexible Ureterorenoscopy in Treatment of Kidney Stones >2 cm: A Review of the Literature
Authors: Atik Yavuz Tarik , Cimen Haci Ibrahim
Published: April 2023

With the advancement of technology, flexible ureterorenoscopy (fURS) has gained popularity among urologists, and fURS is widely accepted as an alternative to extracorporeal shockwave lithotripsy and percutaneous nephrolithotomy. Recent technological and surgical innovations have promoted less invasive treatment options, such as fURS. The use of fibre optics in imaging, an increased deflection capability, and more appropriate dimensions of the device have increased the efficiency of fURS in stone disease treatment. However, there are limited data evaluating the efficacy of fURS in kidney stones >2 cm. Thus, in this review article, the authors assess the efficacy and complications of fURS for the treatment of kidney stones >2 cm.
Penerapan Good Agriculture Practices (GAP) dalam Pascapanen Kopi di Desa Giripurno Kecamatan Bumiaji Kota Batu
Authors: Putra Dwi Fauzia , Suprianto Agung , Wardani Nila Restu
Published: April 2023

Desa Giripurno merupakan daerah pengahasil produksi kopi di Kecamatan Bumiaji Kota Batu. Tepatnya berada di lereng Gunung Arjuno dan Gunung Welirang. Petani kopi di Desa Giripurno pada umumnya belum memahami penanganan dan pengolahan kopi pascapanen dengan baik dan benar. Program Abdimas ini menekankan pada pelatihan pengolahan kopi saat panen dan pascapanen berdasarkan Good Agriculture Practices/GAP On Coffee. Sasaran pelatihan ini adalah petani kopi di Desa Giripurno. Melalui pelatihan ini diharapkan petani kopi mampu mengolah kopi saat panen dan pascapanen dengan baik dan benar. Sehingga petani kopi dapat menghasilkan biji kopi dengan mutu kualitas terbaik. Kegiatan pengabdian ini dilakukan dengan metode pelatihan dan pendampingan. Kegiatan pelatihan adalah: 1) panen, pemetikan buah yang masak melalui sortasi cerry; 2) pascapanen, mulai dari pengupasan, pencucian, penjemuran, sortasi biji kopi sampai penggudangan (proses semi basah). Sedangkang untuk proses kering mulai dari penjemuran, pengupasan, sortasi sampai dengan penggudangan; dan 3) pengenalan dan penggunaan alat/teknologi tepat guna dalam pengolahan kopi. Pendampingan dilakukan dengan tujuan agar terserapnya hasil panen biji kualitas baik di daerah hilir. Keberhasilan progam dapat dilihat dari meningkatnya pengetahuan petani terkait pengelolaan pascapanen kopi sesuai GAP dan meningkatnya harga jual biji kopi hingga 70% dari harga sebelumnya.
Pelatihan Board Game Dan Penerapannya Pada Entrepreneurship Di SMA Negeri 3, Semarang
Authors: Gamayanto Indra , Harisa Ardiawan Bagus , Setiawan Abas , Haryanto Hanny
Published: April 2023

Game merupakan sebuah permainan yang menarik, dimana terdapat interaksi satu sama lain dan dapat meningkatkan motivasi seseorang. Lebih jauh lagi, game adalah perubahan hidup menjadi lebih baik. Pada pengabdian masyarakat ini, kita melakukan penyuluhan dan pelatihan fungsi dan manfaat board game terhadap pembelajaran. Hal ini tentunya menemui beberapa tantangan seperti kompleksitas dari board game agar dapat diterapkan ke dalam beberapa mata pelajaran, sehingga proses belajar mengajar tidak hanya menggunakan cara yang sama, tetapi menerapkan board game agar dapat meningkatkan interaksi komunikasi yang lebih positif. Hal berikutnya adalah keunikkan dari board game sehingga dapat meningkatkan tingkat analisis terhadap pengambilan keputusan. Hal-hal inilah yang menjadi dasar dari pelatihan ini, di sisi yang lain, pengabdian ini juga merupakan pengembangan dari artikel yang pernah kami publikasikan pada 2021 1st Conference on Online Teaching for Mobile Education (OT4ME), yang berjudul Design of the Seven Stages of Educational Game to Generate Gamification. Oleh sebab itu, pengabdian masyarakat ini adalah penerapan dari penelitian yang kami lakukan, sehingga pengabdian masyarakat ini dapat secara sistematis, terstruktur dan komprehensif diterapkan secara konsisten. Hasil dari pengabdian masyarakat ini adalah pemahaman dasar apa itu board game, contoh penerapan board game ke dalam beberapa hal, manfaat dari board game dan bagaimana hal tersebut diimplementasikan ke dalam beberapa sector, khususnya sektor pendidikan.
Perancangan Website dan Pelatihan Pelayanan Online Bagi Perangkat Desa Adisana Kecamatan Kebasen Kabupaten Banyumas
Authors: Somad Muhammad Abdus , Ardiansyah Roni , Irmawati Maydiana , Nuraeni Nia
Published: April 2023

Website merupakan salah satu bagian penting dari sebuah sistem informasi, yang berfungsi sebagai media informasi, sarana publikasi dan media interaksi. Desa Adisana saat ini masih menggunakan pelayanan sistem manual, yang mengharuskan pegawai desa melakukan pelayanan di balai desa. Pelayanan di Desa Adisana tidak optimal karena jam kerja pegawai desa dibatasi untuk menghindari kerumunan sehingga proses permohonan berbagai surat menyurat menjadi lama dan terhambat. Metode ceramah dan praktik digunakan untuk memberikan pengetahuan dan pemahaman tentang penggunaan website pelayanan online desa. Penelitian ini menghasilkan sebuah website desa dan pelayanan online desa, yang dapat membantu masyarakat umum yang membutuhkan informasi tentang Desa Adisana dan membantu masyarakat Desa Adisana yang membutuhkan informasi dan layanan kemasyarakatan Desa Adisana. Pada website ini terdapat menu yang dapat membantu pihak desa memperkenalkan Desa Adisana untuk masyarakat umum seperti menu Profil yang berisi sejarah desa dan struktur organisasi desa, kemudian juga terdapat menu yang dapat membantu pelayanan desa untuk masyarakat seperti menu cek data diri dan layanan online. Dengan adanya website ini diharapkan pelayanan desa menjadi lebih optimal.
Webinar Meningkatkan Kualitas Hidup Bagi Remaja Akhir di Wedoro, Sidoarjo
Authors: Christanti Dessi , Effendy Nurlaila , Prasetyo Eli , Tedjawidjaja Detricia
Published: April 2023

Remaja di Kelurahan Wedoro, Sidoarjo sebagaimana remaja lainnya menghadapi berbagai masalah dalam kehidupannya. Bila mereka tidak bisa mengatasi masalah maka mereka dapat menjadi stres dan menurunkan kualitas hidupnya.  Guna membantu para remaja tersebut agar memiliki bekal bagaimana menghadapi masalah dan meningkatkan kualitas hidupnya maka dirancang sebuah  program webinar sebagai sarana sharing pengetahuan bagaimana meningkatkan kualitas hidup. Melalui webinar ini individu diajak untuk melihat sisi positif dalam dirinya. Dengan demikian, individu akan melihat bahwa dirinya kuat dan mampu menghadapi segala tantangan atau masalah atau kejadian negatif yang datang padanya. Individu tidak lagi rentan terhadap depresi. Indvidu akan memiliki kualitas hidup yang lebih baik. Program ini dilaksanakan pada tanggal 23 April 2022. Kegiatan ini dilaksanan secara daring yaitu via zoom Kegiatan yang berlangsung selama kurang lebih dua jam berlangsung dengan baik. Hasil pre test dan post test menunjukkan peningkatan skor rata-rata peserta mengenai kualitas hidup.
Aplikasi Riset Komunikasi Kuantitatif dan Kualitatif Bagi Mahasiswa
Authors: Putri Puri Kusuma Dwi , Adeni Susri , Zulfiningrum Rahmawati
Published: April 2023

Penulisan riset pada mahasiswa tingkat akhir merupakan hal yang wajib untuk dilakukan. Dalam penulisan riset mahasiswa perlu mengetahui perbedaaan antara metode penelitian kuantitatif dan kualitatif berdasarkan tujuan penelitian yang akan dicapai. Metode penelitian kuantitatif dilakukan untuk menguji hipotesis yang sudah ditentukan oleh peneliti, sedangkan metode penelitian kualitatif dilakukan untuk melakukan generalisasi makna dari fenomena komunikasi. Penelitian dilakukan bukan karena ingin menghindari angka-angka statistik secara kuantitatif atau penulisan makna yang mendalam pada metode penelitian kualitatif. Webinar mengenai aplikasi riset komunikasi kuantitatif dan kualitatif bagi mahasiswa diadakan untuk meningkatkan pengetahuan dan pemahaman mahasiswa mengenai perbedaan penelitian kuantitatif dan kualitatif diselenggarakan pada 20 Mei 2022. Hasil kegiatan pengabdian masyarakat berlangsung dengan baik dan lancar diikuti 79 audiens melalui Zoom meeting dan live streaming YouTube TV KU dari Udinus. Saat webinar berlangsung terjadi proses diskusi dan tanya jawab peserta. Pada akhir webinar diharapkan peserta dapat mengetahui dan memahami pendekatan penelitian yang tepat sehingga dapat digunakan saat melakukan penelitian. Saran dari tim pengabdian agar acara webinar aplikasi riset komunikasi kuantitatif dan kualitatif pada jurusan ilmu komunikasi dapat diinformasikan secara luas.
Edukasi Potensi Bunga Telang sebagai Pewarna Alami di Kecamatan Pesantren Kota Kediri
Authors: Irawati Titik , Maharani Navita , Winahyu Nastiti , Jafar Irwan Ibrahim , Sanipah Sanipah
Published: April 2023

Bunga telang (Clitoria ternatea L.) identik dengan warna biru keunguan dan menghasilkan biji polong berwarna hijau. Tanaman ini tumbuh merambat dan sering dijumpai di pekarangan atau kebun. Sebagian masyarakat belum mengetahui potensi dan manfaat bunga telang. Warna pada bunga telang mengandung antosianin merah hingga ungu pekat. Pigmen antosianin mayoritas tersebar pada bagian bunga, buah dan daun. Kandungan tersebut dapat digunakan sebagai pewarna alami untuk beberapa macam produk olahan makanan atau minuman. Kegiatan ini bertujuan untuk memberi edukasi potensi bunga telang sebagai pewarna alami kepada masyarakat khususnya anggota Pemberdayaan Kesejahteraan Keluarga (PKK) Kelurahan Tempurejo Kecamatan Pesantren Kota Kediri. Kegiatan pengabdian dilaksanakan dengan metode ceramah, tanya jawab dan diskusi secara interaktif. Para peserta sangat antusias dengan tema bunga telang. Sebelum penyampaian materi peserta mengisi pre-test. Setelah sesi tanya jawab dan diskusi, peserta juga dibagikan kuisioner post-test untuk mengukur pemahaman peserta mengenai materi yang telah disampaikan. Hasil evaluasi menunjukkan adanya peningkatan wawasan peserta sebesar 69,3 persen pada pre-test menjadi 94,3 persen pada post-test. Kegiatan pengabdian ditutup dengan pemberian bibit bunga telang kepada peserta untuk ditanam di lahan pekarangan rumah dan produk Teh celup herbal telang serta pewarna alami bunga telang.
Sosialisasi Pemasaran Hasil Bumi Berbasis Digital Marketing di Desa Peneda Gandor, Kabupaten Lombok Timur, NTB
Authors: Nugraha Gibran Satya , Wijaya I Gede Pasek Suta , Bimantoro Fitri , Husodo Ario Yudo , Aranta Arik , Dwiyansaputra Ramaditia
Published: April 2023

Pulau Lombok terkenal sebagai tempat wisata yang banyak dikunjungi oleh wisatawan lokal maupun mancanegara. Selain itu pulau Lombok atau yang dikenal dengan bumi Sasak juga terkenal dengan kekayaan sumber daya alam yang berlimpah ruah, yang tentunya harus dimanfaatkan dengan maksimal khususnya oleh masyarakat Lombok itu sendiri. Desa Peneda Gandor adalah salah satu desa di Kecamatan Labuhan Haji, Kabupaten Lombok Timur. Sebagian besar penduduk Desa Peneda Gandor memiliki pekerjaan sebagai petani. Tidak mengherankan jika berkebun atau bertani menjadi sumber mata pencaharian warga Desa Peneda Gandor, karena hasil bumi yang melimpah tentunya menjadi lahan pekerjaan bagi mereka. Hasil bumi dari Desa Peneda Gandor antara lain adalah tembakau, cabe, tomat, pupuk organik, dsb. Dari permasalahan tersebut dibutuhkan sebuah sosialisasi pemasaran hasil bumi atau sumber daya alam berbasis digital marketing di Desa Peneda Gandor. Kegiatan ini diharapkan dapat membantu warga Desa Peneda Gandor dalam memasarkan hasil buminya, sehingga nantinya dapat mengoptimalkan keuntungan dari hasil penjualannya. Materi yang diajarkan pada sosialisasi ini berkaitan dengan: Teknologi yang dapat dimanfaatkan untuk memasarkan hasil bumi berbasis digital marketing. Tutorial menggunakan kamera smartphone untuk mengambil gambar produk. Kalimat promosi yang menarik perhatian calon pembeli. Tips berkomunikasi yang baik terhadap calon pembeli
Health Literacy: Transisi Pandemi-Endemi Covid-19 pada Guru dalam Akselerasi Pemahaman Siswa di Kecamatan Bulak Surabaya
Authors: Syahrul Fariani , Adi Annis Catur , Rachmayanti Riris Diana , Qurniyawati Eny , Sari Siti Shofiya Novita , Ersanti Arina Mufida , Yamani Laura Navika , Christanto Daniel , Savitri Faradillah Rahmy
Published: April 2023

Penurunan kasus COVID-19 memunculkan isu kesiapan Indonesia menghadapi COVID-19 yang awalnya berstatus pandemi menjadi endemi. Oleh karena proses transisi menuju endemi itu artinya bukan berarti kasus COVID-19 tidak ada sama sekali tapi tetap kasus itu akan ada. Kondisi ini membuat masyarakat harus bersiap untuk terus berdampingan dengan COVID-19. Tujuan kegiatan untuk akselerasi pemahaman guru terhadap kondisi pergesaran pandemi menuju endemi sebagai upaya preventif pasca pandemi COVID-19. Kegiatan inti berupa edukasi kepada guru Sekolah Dasar (SD) dan Sekolah Menengah Pertama (SMP) dengan media buku saku dan materi dalam bentuk digital. Buku saku sebagai bahan saat guru melakukan edukasi pada anak didik dilengkapi dengan materi dalam bentuk digital. Hasil penilaian pengetahuan sebelum dilakukan edukasi (pre-test) mempunyai rata-rata 71,44. Rata-rata nilai pengetahuan meningkat saat post-test, yaitu 78,67. Evaluasi kehadiran yaitu 45 guru yang hadir dari 50 guru yang diundang (90%). Kegiatan ini telah memberikan kontribusi peningkatan pengetahuan guru SD dan SMP terkait pemahaman kondisi pergeseran pandemi menuju endemi, sehingga diharapkan guru SD dan SMP bisa melakukan edukasi kepada anak didik sebagai upaya preventif pasca pandemi COVID-19.
OPTIMALISASI PENJADWALAN PROYEK PEMBANGUNAN DRAINASE DENGAN FUZZY CRITICAL PATH METHOD
Authors: Dwicahyani Pramesti , Sani Asrul , Arman Arman
Published: April 2023

Kota Kendari khususnya kawasan TPU Punggolaka menjadi area publik sebagai tempat pemakaman jenazah warga Kota Kendari dan daerah sekitarnya. Permasalahan TPU Punggolaka pada saat musim hujan terjadi banjir akibat buruknya sistem drainase pada wilayah tersebut.Tujuan penelitian ini adalah untuk memodelkan jaringan proyek pembangunan drainase TPU Punggolaka, Kota Kendari dan menentukan lintasan kritis pada jaringan proyek pembangunan drainase dengan Fuzzy Critical Path Method (FCPM). Dengan menggunakan FCPM, jaringan kerja pada penjadwalan proyek pembangunan drainase tersebut menghasilkan suatu lintasan kritis. Penelitian ini dilakukan dengan menghitung earliest time, latest time dan slack time menggunakan bilangan fuzzy trapesium. Setelah itu, dilakukan defuzzifikasi terhadap nilai slack time menggunakan metode centroid. Penelitian ini juga menggunakan program komputasi menggunakan Bahasa pemrograman Python.Hasil dari penelitian ini, perhitungan nilai earliest time dengan perhitungan maju FCPM dihasilkan total waktu penyelesaian proyek, yaitu (61, 69, 79, 88) hari, dengan perkiraan durasi optimum selesainya pekerjaan adalah 69 sampai 79 hari.Perhitungan nilai latest time dengan perhitungan mundur FCPM dihasilkan total waktu paling lambat dimulainya pekerjaan proyek, yaitu (-12, 4, 23, 39) hari, dengan perkiraan durasi optimum dimulainya pekerjaan adalah 4 sampai 23 hari.Dari lintasan kritis,diperoleh jumlah durasi maksimum untuk  mengerjakan proyek pembangunan drainase TPU Punggolaka Kota Kendari yaitu 75 hari. Hasil perhitungan maju FCPM, durasi maksimumdan pemrograman Python yang dihasilkan menunjukkan suatu kesamaan jumlah waktu dengan pelaksanaan proyek.
APLIKASI ANALISIS RANTAI MARKOV UNTUK MEMPREDIKSI STATUS PASIEN RUMAH SAKIT UMUM DAERAH (RSUD) KABUPATEN BUTON
Authors: Nuryam Siti , Arman Arman , Mukhtar Norma , Jufra Jufra , La Gubu La Gubu
Published: April 2023

Penelitian ini bertujuan untuk menentukan model rantai Markov dan model peluang steady state untuk memprediksi status pasien RSUD Kabupaten Buton. Pengambilan data penelitian diperoleh dari data sekunder Reka Medik RSUD Kabupaten Buton selama tahun 2021. Selanjutnya dilakukan analisis data dengan menggunakan rantai Markov untuk memprediksi status pasien. Proses perhitungan dilakukan dengan membuat program Matlab untuk mempermudah perkalian matriks. Data status pasien terlebih dahulu diubah menjadi data probabilitas kemudian dibentuk kedalam matriks probabilitas transisi. Hasil yang diperoleh untuk status pasien setelah dilakukan analisis rantai Markov adalah perkiraan pada periode ke-5 atau pada tahun 2026 yaitu  pasien yang masuk dalam keadaan sakit ringan, sedang, dan parah dengan status keluar dalam keadaan membaik,  pasien yang masuk dalam keadaan sakit ringan, sedang, dan parah dengan status keluar dalam keadaan tidak sembuh, serta  pasien yang masuk dalam keadaan sakit ringan, sedang, dan parah dengan status keluar dalam keadaan meninggal.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEMAMPUAN MEMBACA SISWA DENGAN METODE REGRESI PROBIT ORDINAL (STUDI KASUS SISWA SD SE-SULAWESI TENGGARA)
Authors: Rasdiansastra Waode , Adi Wibawa Gusti , Abapihi Bahriddin
Published: April 2023

Keterampilan membaca siswa memiliki peran penting dalam pengembangan diri secara berkelanjutan dan sekaligus sebagai fondasi dalam pendidikan siswa di lembaga formal. Tujuan penelitian ini adalah mengetahui karakteristik pada variabel-variabel kemampuan membaca siswa dan estimasi model probit dari faktor-faktor yang mempengaruhi secara signifikan kemampuan membaca siswa(i) SD di Sulawesi Tenggara dengan menggunakan software SPSS. Penelitian ini menggunakan data kategori bertingkat atau biasa disebut data skala ordinal sebagai variabel dependen dan metode yang digunakan adalah regresi probit ordinal. Hasil analisis menunjukkan bahwa variabel yang signifikan terhadap kemampuan membaca siswa(i) adalah jenis kelamin siswa(i) (X1), mengulang kelas (X3), belajar/membaca di rumah (X4), dan guru kelas pernah memperoleh pelatihan khusus tentang cara mengajar membaca (X11). Uji kesesuaian model menunjukkan bahwa nilai signifikansi  artinya model regresi probit ordinal yang terbentuk telah sesuai atau tidak terdapat perbedaan antara hasil pengamatan dengan hasil model prediksi.
Absence of Nkx2-3 induces ectopic lymphatic endothelial differentiation associated with impaired extramedullary stress hematopoiesis in the spleen
Authors: Gábris Fanni , Kiss Gabriella , Szirmay Balázs , Szomor Árpád , Berta Gergely , Jakus Zoltán , Kellermayer Zoltán , Balogh Péter
Published: April 2023

The red and white pulps as two main parts of the spleen are arranged around distinct types of vasculature, and perform significantly different functions in both humans and mice. Previous observations indicated a profound alteration of the local vessel specialization in mice lacking Nkx2-3 homeodomain transcription factor, including contradictory results suggesting presence of an ectopic lymphatic vascular structure. Furthermore, how the absence of Nkx2-3 and the consequential changes in endothelial components affect the extramedullary hematopoietic activity restricted to the splenic red pulp is unknown. In this work, we investigated the role of Nkx2-3 homeodomain transcription factor as a major morphogenic determinant for vascular specification, and its effect in the extramedullary hematopoiesis following acute blood loss and pharmacological stimulation of megakaryocyte differentiation after treatment with thrombopoietin-receptor mimetic Romiplostim. We found that, in mice lacking Nkx2-3, Prox1-positive lymphatic capillaries containing gp38/CD31 double positive lymphatic endothelial cells develop, arranged into an extensive meshwork, while the Clever1-positive venous segments of red pulp blood vasculature are absent. This lymphatic endothelial shift is coupled with a severely compromised splenic erythropoiesis and a significantly reduced splenic megakaryocyte colony formation following Romiplostim treatment in mice lacking Nkx2-3. These findings indicate that the shift of microvascular patterning in the absence of Nkx2-3 includes the emergence of ectopic Prox1-positive lymphatic vessels, and that this pivoting towards lymph node-like vascular patterning is associated with an impaired reserve hematopoietic capacity of the splenic red pulp.
What is metacognitive reflection? The moderating role of metacognition on emotional regulation and reflection
Authors: Merkebu Jerusalem , Kitsantas Anastasia , Durning Steven J. , Ma TInglan
Published: April 2023

Introduction

This paper explores the trilateral relationship among metacognition, emotional regulation, and reflection under the integrative framework of metacognitive reflection.

Methods

Data were gathered from undergraduate participants at a large state university on the East Coast (N= 493). The quantitative data were derived from: the Metacognitive Awareness Inventory (MAI), the Self-Reflection and Insight Scale (SR-IS), and the Cognitive Reappraisal Scale (ERQ). Data analysis consisted of structural equation modeling (SEM) in which the associations between latent constructs were tested. Emotional regulation and metacognition were found to be positively and significantly related to the latent construct of reflection.

Results

SEM results indicated that emotional regulation (which emerged as the strongest predictor) together with metacognition predicted 52% of the variance in reflection. Moreover, the latent moderation model showed that metacognition significantly moderated the relationship between emotional regulation and reflection such that emotional regulation was a strong and positive predictor of reflection when students simultaneously showed high levels of metacognition. In contrast, emotional regulation did not significantly predict reflection for students with low levels of metacognition. The alternative model showed that emotional regulation also moderated the relationship between metacognition and reflection such that metacognition contributed to reflection the most when participants simultaneously showed high levels of emotional regulation.

Discussion

These findings suggest the interaction between metacognition and emotional regulation is critical in the gamut of reflection.
Industrial users load pattern extraction method based on multidimensional electrical consumption feature construction
Authors: Wang Li , Zhao Jian , Xia Xiangwu , Liu Jun , Lu Yang , Zhao Lei
Published: April 2023

The rapid development of renewable energy generation aggravates the imbalance between supply and demand in power grid, and exploring the potential of demand side resource can effectively improve such problems. Industrial users (IU) is an important demand response resource of power grid, and mining the load patterns of IU is the basis of studying the demand response ability of IU, which plays an important role in the safe operation and lean management of power grid. Lately, the popularity of advanced metering infrastructures provides data support for studying the load patterns of IU. However, the high dimensionality and the complex non-linear relationship of IU’s load data bring difficulties to the task of clustering. To solve the above problems, this paper proposes a load pattern extraction method based on multidimensional electrical consumption feature construction. Firstly, industrial load characteristic set of IU is created with five load characteristic indexes weighted by improved entropy weight method. In addition, convolutional autoencoder is established to extract the temporal feature of industrial load data which is combined with industrial load characteristic set to build a multidimensional feature set (MFS) for IU and finish multidimensional electrical consumption feature construction (MECFC). Then, MFS is used as the input of Self-Organization Map network to select the initial clustering centers of K-means algorithm, overcoming the problem of local optimal solution, and complete the IU daily load clustering. The experiment shows that the algorithm based on MECFC solves the local optimal problem and have better performance in stability and clustering effect than traditional methods.
Effect of breathing exercises on oxidative stress biomarkers in humans: A systematic review and meta-analysis
Authors: Li Ting-ting , Wang Hong-ying , Zhang Hui , Zhang Ping-ping , Zhang Ming-chen , Feng Hai-yang , Duan Xiao-yong , Liu Wen-bo , Wang Xiao-wen , Sun Zhong-guang
Published: April 2023

Background

Breathing exercises improve oxidative stress in healthy young adults and patients with diabetes, hypertension, and chronic obstructive pulmonary disease. Furthermore, the mechanism of respiratory intervention is controversial. Therefore, in this meta-analysis, we aimed to systematically evaluate the effects of breathing exercises on oxidative stress biomarkers in humans and provide evidence for the clinical application of breathing exercises.

Methods

The Embase, PubMed, Cochrane Library, Web of Science, CNKI, and WANFANG databases were searched for studies about the effects of breathing exercises on human oxidative stress levels, with no restraints regarding time, race, or language. The experimental group included various breathing exercises, and the outcome index included malondialdehyde, superoxide dismutase, and glutathione, nitric oxide, vitamin C, or total antioxidant capacity levels from a randomized controlled trial. Data were extracted by more than two authors and reviewed by one author.

Results

Ten studies were included from five countries. Data from patients with no disease, chronic obstructive pulmonary disease, hypertension, or diabetes were included. Participants who performed breathing exercises had greater changes in the included biomarkers than those who did not, suggesting that these biomarkers can be used to evaluate oxidative stress after respiratory interventions.

Conclusion

Breathing exercises increased SOD and GSH activities and decreased MDA content.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022337119, identifier CRD42022337119.
Carapace microbiota in American lobsters (Homarus americanus) associated with epizootic shell disease and the green gland
Authors: Schaubeck Anna , Cao Dianjun , Cavaleri Vincent , Mun Seyoung , Jeon Soo Jin
Published: April 2023

Epizootic Shell Disease (ESD) has posed a great threat, both ecologically and economically, to the American lobster population of Long Island Sound since its emergence in the late 1990s. Because of the polymicrobial nature of carapace infections, causative agents for ESD remain unclear. In this study, we aimed to identify carapace microbiota associated with ESD and its potential impact on the microbiota of internal organs (green gland, hepatopancreas, intestine, and testis) using high-throughput 16S rRNA gene sequencing. We found that lobsters with ESD harbored specific carapace microbiota characterized by high abundance of Aquimarina, which was significantly different from healthy lobsters. PICRUSt analysis showed that metabolic pathways such as amino acid metabolism were enriched in the carapace microbiota of lobsters with ESD. Aquimarina, Halocynthiibacter, and Tenacibaculum were identified as core carapace bacteria associated with ESD. Particularly, Aquimarina and Halocynthiibacter were detected in the green gland, hepatopancreas, and testis of lobsters with ESD, but were absent from all internal organs tested in healthy lobsters. Hierarchical clustering analysis revealed that the carapace microbiota of lobsters with ESD was closely related to the green gland microbiota, whereas the carapace microbiota of healthy lobsters was more similar to the testis microbiota. Taken together, our findings suggest that ESD is associated with alterations in the structure and function of carapace microbiota, which may facilitate the invasion of bacteria into the green gland.
Inhibitory effects of Stevioside on Streptococcus mutans and Candida albicans dual-species biofilm
Authors: Guo Mingzhu , Yang Kuan , Zhou Zhifei , Chen Yujiang , Zhou Ziye , Chen Peng , Huang Ruizhe , Wang Xiaojing
Published: April 2023

Introduction

Streptococcus mutans is the most prevalent biofilm-forming pathogen in dental caries, while Candida albicans is often detected in the presence of S. mutans.

Methods

We aimed to evaluate the anti-caries effect of stevioside in medium trypticase soy broth (TSB) with or without sucrose supplementation compared with the same sweetness sucrose and xylitol in a dual-species model of S. mutans and C. albicans, based on planktonic growth, crystal violet assay, acid production, biofilm structural imaging, confocal laser scanning microscopy, and RNA sequencing.

Results

Our results showed that compared with sucrose, stevioside significantly inhibited planktonic growth and acid production, changed the structure of the mixed biofilm, and reduced the viability of biofilm and the production of extracellular polysaccharides in dual-species biofilm. Through RNA-seq, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway impact analysis showed that stevioside decreased sucrose metabolism and increased galactose and intracellular polysaccharide metabolism in S. mutans, and decreased genes related to GPI-modified proteins and secreted aspartyl proteinase (SAP) family in C. albicans. In contrast to xylitol, stevioside also inhibited the transformation of fungal morphology of C. albicans, which did not form mycelia and thus had reduced pathogenicity. Stevioside revealed a superior suppression of dual-species biofilm formation compared to sucrose and a similar anti-caries effect with xylitol. However, sucrose supplementation diminished the suppression of stevioside on S. mutans and C. albicans.

Conclusions

Our study is the first to confirm that stevioside has anticariogenic effects on S. mutans and C. albicans in a dual-species biofilm. As a substitute for sucrose, it may help reduce the risk of developing dental caries.
Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite
Authors: Gharehdaghi Zahra , Naghib Seyed Morteza , Rahimi Rahmatollah , Bakhshi Atin , Kefayat Amirhosein , shamaeizadeh Armin , Molaabasi Fatemeh
Published: April 2023

Cu-BTC framework has received a considerable attention in recent years as a drug carrier candidate for cancer treatment due to its unique structural properties and promising biocompatibility. However, its intrinsic deficiency for medical imaging potentially limits its bioapplications; To address this subject, a magnetic nano/microscale MOF has been successfully fabricated by introducing Fe3O4 nanoparticles as an imaging agent into the porous isoreticular MOF [Cu3(BTC)2] as a drug carrier. The synthesized magnetic MOFs exhibits a high loading capacity (40.5%) toward the model anticancer DOX with an excellent pH-responsive drug release. The proposed nanocomposite not only possesses large surface area, high magnetic response, large mesopore volume, high transverse relaxivity (r2) and good stability but also exhibits superior biocompatibility, specific tumor cellular uptake, and significant cancer cell viability inhibitory effect without any targeting agent. It is expected that the synthesized magnetic nano/microcomposite may be used for clinical purposes and can also serve as a platform for photoactive antibacterial therapy ae well as pH/GSH/photo-triple-responsive nanocarrier.
Structural plasticity of the axon initial segment in rat hippocampal granule cells following high frequency stimulation and LTP induction
Authors: Jungenitz Tassilo , Bird Alexander , Engelhardt Maren , Jedlicka Peter , Schwarzacher Stephan W. , Deller Thomas
Published: April 2023

The axon initial segment (AIS) is the site of action potential initiation and important for the integration of synaptic input. Length and localization of the AIS are dynamic, modulated by afferent activity and contribute to the homeostatic control of neuronal excitability. Synaptopodin is a plasticity-related protein expressed by the majority of telencephalic neurons. It is required for the formation of cisternal organelles within the AIS and an excellent marker to identify these enigmatic organelles at the light microscopic level. Here we applied 2 h of high frequency stimulation of the medial perforant path in rats in vivo to induce a strong long-term potentiation of dentate gyrus granule cells. Immunolabeling for βIV-spectrin and synaptopodin were performed to study structural changes of the AIS and its cisternal organelles. Three-dimensional analysis of the AIS revealed a shortening of the AIS and a corresponding reduction of the number of synaptopodin clusters. These data demonstrate a rapid structural plasticity of the AIS and its cisternal organelles to strong stimulation, indicating a homeostatic response of the entire AIS compartment.
Correlation between dietary patterns and cognitive function in older Chinese adults: A representative cross-sectional study
Authors: Gou Ruoyu , Qin Jian , Pang Weiyi , Cai Jiansheng , Luo Tingyu , He Kailian , Xiao Song , Tang Xu , Zhang Zhiyong , Li You
Published: April 2023

Objective

The objective of this study was to investigate the relationship between dietary patterns and cognitive function in older adults (≥60 years old).

Methods

Food intake was quantitatively assessed by the Food Frequency Questionnaire (FFQ), and cognitive function was assessed by the Chinese version of the Simple Mental State Examination Scale (MMSE). Four major dietary patterns were identified by the factor analysis (FA) method. The relationship between dietary patterns and cognitive function was evaluated by logistic regression.

Results

A total of 884 participants were included in the study. Four dietary patterns (vegetable and mushroom, oil and salt, seafood and alcohol, and oil tea dietary patterns) were extracted. In the total population, Model III results showed that the fourth quartile of dietary pattern factor scores for the vegetable and mushroom pattern was 0.399 and 7.056. The vegetable and mushroom dietary pattern may be a protective factor for cognitive function, with p-value = 0.033, OR (95% CI): 0.578 (0.348, 0.951) in Model III (adjusted for covariates: sex, ethnic, marital, agricultural activities, smoking, drinking, hypertension, diabetes, dyslipidemia, BMI, and dietary fiber). In the ethnic stratification analysis, the scores of dietary pattern factors of the vegetable and mushroom among the Yao participants were 0.333 and 5.064. The Vegetable and mushroom diet pattern may be a protective factor for cognitive function, p-value = 0.012, OR (95% CI): 0.415 (0.206, 0.815).

Conclusion

The fourth quartile of the vegetable and mushroom dietary pattern scores showed dose-dependent and a strong correlation with cognitive function. Currently, increasing vegetable and mushroom intake may be one of the effective ways to prevent and mitigate cognitive decline. It is recommended to increase the dietary intake of vegetables and mushroom foods.
Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan
Authors: Alhaj Omar A. , Trabelsi Khaled , Younes Abdallah M. , Shivappa Nitin , Bragazzi Nicola L. , Hebert James R. , Jahrami Haitham A.
Published: April 2023

Background

Multiple sclerosis, a chronic inflammatory disease in young and middle-aged adults, is one of the leading causes of non-traumatic disability in adults. Diet is known to have an important role in the modulating inflammatory processes and influencing molecular pathways.

Purpose

This study aims to examine the association of the inflammatory capacity of diet measured by DII with MS in Jordan.

Methods

This prevalent case-control study included participants of both sexes, aged between 20 and 60 years. The cases (n = 541) had a confirmed diagnosis of prevalent Multiple Sclerosis (MS) in the previous 3 years, and controls (n = 607) were apparently healthy individuals matched on sex and age (42 ± 4 years). A validated Arabic food frequency questionnaire (FFQ) was utilized to obtain estimated dietary intake. Dietary data from the FFQ were analyzed using ESHA’s Food Processor® nutrition analysis software, and the results were used to calculate the DII scores. Logistic regression analyses, controlling for covariates such as age, sex, body mass index, and smoking status, were used to measure the association between DII score and MS outcomes.

Results

Cases represent a mixed sample of MS phenotypes and controls were comparable on age and sex. However, controls tended to be taller, lighter, had a lower BMI, and had a lower smoking rate. After controlling for age, BMI, sex, and smoking status, there was a consistent increase in MS risk according to DII score, with a 10-fold increase in odds in quartile 4 vs. quartile 1 [ORquartile 4vs1 = 10.17 (95% CI: 6.88; 15.04)]. For each point increase in DII score, there was nearly a doubling of odds [OR1 = 1.75 (95% CI: 1.59; 1.92)]. Individual nutrients and food values aligned according to their contribution to the DII score calculations.

Conclusion

The findings of this study, obtained in MS patients with varied illness duration over the previous 3 years, are consistent with an association between the overall inflammatory potential of diet and MS odds. Our findings among MS participants showed a significantly more pro-inflammatory DII scores than age- and sex-matched controls. Our results also suggest that MS group had a diet rich in pro-inflammatory foods and nutrients.
Mode of presentation and performance of serology assays for diagnosing celiac disease: A single-center study in the United Arab Emirates
Authors: Shatnawei Abdullah , AlNababteh Asma H. , Govender Romona Devi , Al-Shamsi Saif , AlJarrah Ammar , Al-Rifai Rami H.
Published: April 2023

Objective

To characterize patients with celiac disease (CD), examines the clinical spectrum of CD, and evaluate the performance of serologic tests used for CD screening, in the United Arab Emirates (UAE).

Methods

Medical charts of patients received at the Digestive Diseases Institute of Cleveland Clinic Abu Dhabi from January 2015 to December 2020 were reviewed. Patients who were screened for four serologic biomarkers (anti-tissue transglutaminase IgA [Anti-tTG-IgA], anti-tissue transglutaminase IgG [Anti-TtG-IgG], anti-deamidated gliadin peptide IgG [Anti-DGP-IgG], and anti-deamidated gliadin peptide IgA [Anti-DGP-IgA]) were included. Histopathology was performed on patients with the seropositive test. Marsh score > 1 considered to confirm CD. Characteristics of the Anti-tTG-IgA seropositive patients were described and that correlated with histopathologically confirmed CD were explored.

Results

Of the 6,239 patients, 1.4, 2.9, 4.7, and 4.9%, were seropositive to Anti-tTG-IgG, Anti-TtG-IgA, Anti-DGP-IgA, and Anti-DGP-IgG, respectively. Overall, 7.7% were seropositive to either of the four biomarkers. Of the biopsy-screened 300 patients, 38.7% (1.9% of the total serologically screened) were confirmed with CD. The mean age of Anti-TtG-IgA seropositive patients was 32.1 ± 10.3 SD years, 72% of them were females, and 93.4% were Emirati. In those patients, overweight (28.7%) and obesity (24.7%) were common while 5.8% of patients were underweight. Anemia prevalence was 46.7%, 21.3% had Gastroesophageal reflux disease (GERD), 7.7% with autoimmune thyroid disease, 5.5% (type 1), and 3.3% (type 2) were diabetic. Vitamin D deficiency was observed in 47.8% of the Anti-TtG IgA seropositive patients. Twelve (10.3%) histopathologically confirmed CD patients were seronegative to Anti-TtG-IgA but seropositive to anti-DGP-IgA and/or Anti-DGP-IgG. Body mass index, GERD, autoimmune thyroid disease, type 1 diabetes, asthma, hemoglobin, and vitamin D concentration, were all correlated with biopsy-confirmed CD (P < 0.05). Compared to the gold-standard biopsy test, Anti-TtG-IgA had the highest sensitivity (89.7%) and specificity (83.7%).

Conclusion

Three and two of every 100 patients were serologically (anti-tTG-IgA positive) and histopathologically diagnosed with CD, respectively. Although Anti-TtG-IgA is the most sensitive, specific, and commonly used test, one of every ten histopathologically confirmed patients and Anti-tTG-IgA seronegative were seropositive to Anti-DGP. To avoid missing patients with CD, a comprehensive serological investigation covering DGP-IgG/IgA is warranted.
SAA1 identified as a potential prediction biomarker for metastasis of hepatocellular carcinoma via multi-omics approaches
Authors: Li Gang , Shen Qingrong , Xu Haotian , Zhou Ying , Li Cuiping , Li Yasi , He Min
Published: April 2023

Background

Metastasis is the major cause of high recurrence and mortality of hepatocellular carcinoma (HCC). Unfortunately, there are few reports on effective biomarkers of HCC metastasis. Previous studies have reported that SAA1 may be a predictor and prognostic biomarker for multiple malignant tumors. However, the role of SAA1 in HCC has not yet been investigated.

Methods

We applied RNA sequencing and proteomics analysis to investigate the expression landscape of HCC cell lines and patient serum, respectively. SAA1 is a common key gene and listed as a candidate biomarker of HCC metastasis. It was validated in two cell lines, 107 participants serum, and 63 matched HCC and adjacent non-tumorous liver tissues. Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx), and The Cancer Genome Atlas (TCGA) datasets were integrated to explore SAA1 expression among various cell types and organs. The diagnostic and prognostic value of SAA1 in HCC were determined through receiver operating characteristic (ROC) and Kaplan–Meier curves. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein-protein interaction (PPI) network were constructed for SAA1, as well as for its co−expressed genes. We further analyzed the correlation between SAA1 and co-expression genes.

Results

We found 7 differentially expressed genes (DEGs) and 14 differentially expressed proteins (DEPs) were related to HCC metastasis. SAA1, a key candidate biomarker, was highly enriched in hepatocytes and liver organ, and it was also highly expressed in HCC cells and the serum and tissues of HCC patients. The results of ROC curve analysis indicated that SAA1 had better predictive values for distinguishing HCC metastasis from non-metastasis. Kaplan-Meier curve analysis revealed that HCC patients with higher SAA1 expression had worse overall survival.

Conclusions

Our findings provide new insights into HCC metastasis by identifying candidate gene prediction biomarkers for HCC metastasis.
Comparison between supine and prone patient setup for lumbosacral spinal stereotactic body radiosurgery with CyberKnife
Authors: Li Jun , Kong Xianghui , cheng Cheng , Wang Gong , Zhuang Hongqing , Yang Ruijie
Published: April 2023

Objective

The aim of this study is to analyze which tracking modality is more suitable for stereotactic body radiosurgery of lumbosacral spinal tumors by comparing prone and supine patient treatment setup.

Methods

Eighteen patients with lumbosacral spinal tumors were selected. CT simulation was performed in the supine position (fixed with a vacuum cushion) and prone position (fixed with a thermoplastic mask and prone plate), respectively. The plans in the supine and prone positions were designed using the xsight spine tracking (XST) and xsight spine prone tracking (XSPT) modalities, respectively. The dose-volume histogram (DVH) parameters, namely, V100%, D95%, Dmean, conformity index (CI), and heterogeneity index (HI) in planning target volume (PTV), as well as Dmax, D0.1cc, D1cc, and D5cc in the cauda equina and bowel were recorded. The supine plans were simulation plans and were not used for treatment, which were only used to record the alignment errors. The spinal tracking correction errors (alignment error) and correlation errors of the synchrony respiratory model in the prone position were recorded during the treatment. After treatment, the simulation plan of the supine position was implemented and the spinal tracking correction errors were recorded. The parameters of correction error and DVH parameters for the two positions were analyzed using the paired t-test to compare the difference in positioning accuracy and dose distribution. In addition, the correlation errors of the synchrony respiratory model in the prone position were analyzed to evaluate the prediction accuracy of the synchrony model.

Results

For patient setup, the correction error of the supine position in interior/posterior was (0.18 ± 0.16) mm and the prone position was (0.31 ± 0.26) mm (P< 0.05). The correction error of the supine position in inferior/superior was (0.27 ± 0.24) mm, and the prone position was (0.5 ± 0.4) mm (P< 0.05). The average correlation errors of the synchrony model for left/right, inferior/superior, and anterior/posterior in the prone position were (0.21 ± 0.11) mm, (0.41 ± 0.38) mm, and (0.68 ± 0.42) mm, respectively. For the dose distribution, compared with prone plans, the average CI in supine plans was increased by 4.5% (P< 0.05). There was no significant difference in HI, PTV V100%, D95%, and Dmean between the prone and supine plans. Compared with supine plans, average D1cc and D5cc for the cauda equina was significantly decreased by 4.7 and 15.3% in the prone plan (P< 0.05). For the bowel, average Dmax, D0.1cc, D1cc, and D5cc were reduced by 8.0, 7.7, 5.2, and 26.6% in prone plans (P< 0.05) compared with supine plans.

Conclusion

Compared with the supine setup, the prone setup combined with XSPT modality for the lumbosacral spinal stereotactic body radiosurgery can spare the bowel and cauda equina of the middle and low dose irradiation, and decrease the number of beams and monitor units.