bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma
Authors: Liao Rachel G. , Jung Joonil , Tchaicha Jeremy , Wilkerson Matthew D. , Sivachenko Andrey , Beauchamp Ellen M. , Liu Qingsong , Pugh Trevor J. , Pedamallu Chandra Sekhar , Hayes D. Neil , Gray Nathanael S. , Getz Gad , Wong Kwok-Kin , Haddad Robert I. , Meyerson Matthew , Hammerman Peter S.
Published: April 2023

PDF file - 55K, Xenograft tumor images not included in Figure 2.
Supplementary Table 2 from Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions
Authors: Kwong Lawrence N. , Chin Lynda
Published: April 2023

XLSX file - 131KB, Genotypes and characteristics of human melanoma cell lines used in this study.
Supplementary Figure 3 from PP2A-B55β Antagonizes Cyclin E1 Proteolysis and Promotes Its Dysregulation in Cancer
Authors: Tan YingMeei , Sun Dahui , Jiang Weijian , Klotz-Noack Kathleen , Vashisht Ajay A. , Wohlschlegel James , Widschwendter Martin , Spruck Charles
Published: April 2023

PDF file - 235KB, Cell cycle analysis of MDA-MB-231 cells knocked down for B55beta expression. Cells were transfected with control or B55beta siRNA and 48 hrs later stained with propidium iodide and cell cycle kinetics determined by flow cytometry. Percentage of cells in G1, S and G2/M phases are shown on the right.
Supplementary Figure S9 from Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity
Authors: Tan Peng H. , Tyrrell Helen E.J. , Gao Liquan , Xu Danmei , Quan Jianchao , Gill Dipender , Rai Lena , Ding Yunchuan , Plant Gareth , Chen Yuan , Xue John Z. , Handa Ashok I. , Greenall Michael J. , Walsh Kenneth , Xue Shao-An
Published: April 2023

Elevated APN receptor signaling in DC promotes T cell tolerance and abrogates tumor protection in vivo.
Supplementary Figure 3 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells
Authors: Goc Jérémy , Germain Claire , Vo-Bourgais Thi Kim Duy , Lupo Audrey , Klein Christophe , Knockaert Samantha , de Chaisemartin Luc , Ouakrim Hanane , Becht Etienne , Alifano Marco , Validire Pierre , Remark Romain , Hammond Scott A. , Cremer Isabelle , Damotte Diane , Fridman Wolf-Herman , Sautès-Fridman Catherine , Dieu-Nosjean Marie-Caroline
Published: April 2023

PDF file - 139K, Selective presence of CD62L+ T cells in TLS.
Supplementary Figure S10 from Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity
Authors: Tan Peng H. , Tyrrell Helen E.J. , Gao Liquan , Xu Danmei , Quan Jianchao , Gill Dipender , Rai Lena , Ding Yunchuan , Plant Gareth , Chen Yuan , Xue John Z. , Handa Ashok I. , Greenall Michael J. , Walsh Kenneth , Xue Shao-An
Published: April 2023

Impaired ability of DCs derived from stage III and IV patients to mount antigenic response and inverse co-relation of serum APN with disease progression.
Supplementary Figure Legends from microRNA-148a Is a Prognostic oncomiR That Targets MIG6 and BIM to Regulate EGFR and Apoptosis in Glioblastoma
Authors: Kim Jungeun , Zhang Ying , Skalski Michael , Hayes Josie , Kefas Benjamin , Schiff David , Purow Benjamin , Parsons Sarah , Lawler Sean , Abounader Roger
Published: April 2023

PDF file - 72K
Supplementary Figure 3 from microRNA-148a Is a Prognostic oncomiR That Targets MIG6 and BIM to Regulate EGFR and Apoptosis in Glioblastoma
Authors: Kim Jungeun , Zhang Ying , Skalski Michael , Hayes Josie , Kefas Benjamin , Schiff David , Purow Benjamin , Parsons Sarah , Lawler Sean , Abounader Roger
Published: April 2023

PDF file - 20K, Transfection efficiency of U87 cells infected with lentiviruses encoding anti-miR-148, mCherry, and hygromycin resistance gene.
Supplementary Figures 1 through 4 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Authors: Mémin Elisabeth , Hoque Mainul , Jain Mohit R. , Heller Debra S. , Li Hong , Cracchiolo Bernadette , Hanauske-Abel Hartmut M. , Pe'ery Tsafi , Mathews Michael B.
Published: April 2023

PDF - 468K, Fig. S1. Inhibition of DOHH by ciclopirox and deferiprone. Fig. S2. Cell cycle analysis. Fig. S3. Effects of CPX and DEF on cell size and morphology. Fig. S4. Effect of CPX and DEF on HeLa cell proteins analyzed by 2D gel electrophoresis.
Supplementary Table 3 from Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Authors: Tahara Tomomitsu , Yamamoto Eiichiro , Suzuki Hiromu , Maruyama Reo , Chung Woonbok , Garriga Judith , Jelinek Jaroslav , Yamano Hiro-o , Sugai Tamotsu , An Byonggu , Shureiqi Imad , Toyota Minoru , Kondo Yutaka , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

XLSX file - 9K, Correlation between F.nucleatum and Pan-fuso bacterium in normal tissues.
Supplementary Table 1 from Hypoxia-Inducible Factor-1 Promotes Pancreatic Ductal Adenocarcinoma Invasion and Metastasis by Activating Transcription of the Actin-Bundling Protein Fascin
Authors: Zhao Xiao , Gao Song , Ren He , Sun Wei , Zhang Huan , Sun Jianwei , Yang Shengyu , Hao Jihui
Published: April 2023

PDF file - 51K, Antibodies, siRNAs and primers.
Supplementary Figure 3 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells
Authors: Lal Shruti , Burkhart Richard A. , Beeharry Neil , Bhattacharjee Vikram , Londin Eric R. , Cozzitorto Joseph A. , Romeo Carmella , Jimbo Masaya , Norris Zoë A. , Yeo Charles J. , Sawicki Janet A. , Winter Jordan M. , Rigoutsos Isidore , Yen Timothy J. , Brody Jonathan R.
Published: April 2023

PDF file - 471KB, HuR silencing induced DNA damage breaks in PL5 cells.
Supplementary Figure 7 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 45KB, Supplementary Figure S7 shows the molecular structure and pharmacokinetic of TBK1-II In NOD/SCID mice.
Supplementary Figure 4 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 131KB, Supplementary Figure S4 shows the effect of autophagy inhibitors CQ and 5-MA on proliferation and survival of HER2+ mouse and human breast cancer cell lines.
Supplementary Figure 3 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 55KB, Supplementary Figure S3 shows expression of kinase hits in primary and secondary Her2/Neu tumor cells from RNA profiling analysis.
Supplementary Figure 2 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 67KB, Supplementary Figure S2 shows results from the primary and validation screens with hits on sphere only or both sphere and monolayer, as well as sensitivity of HC11 cells.
Supplementary Figure 1 from Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Authors: Meeker Stacey , Seamons Audrey , Paik Jisun , Treuting Piper M. , Brabb Thea , Grady William M. , Maggio-Price Lillian
Published: April 2023

PDF file - 99K, Study design.
Data Supplement from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L.
Published: April 2023

Supplementary Figure 4. Differential suppression of CD4+ and CD8+ T cell activation by granulocytic and monocytic MDSC isolated from 4T1.2 or 4T1.2-BMP4 tumor bearing mice
Supplementary Table 2 from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: April 2023

PDF file - 56K, SUPPLEMENTARY TABLE 2. Functional analysis of EV proteins identified by mass spectrometry.
Data Supplement from AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
Authors: Yin JuanJuan , Liu Yen-Nien , Tillman Heather , Barrett Ben , Hewitt Stephen , Ylaya Kris , Fang Lei , Lake Ross , Corey Eva , Morrissey Colm , Vessella Robert , Kelly Kathleen
Published: April 2023

Supplemental Figure 2. (A) Representative IHC staining in tissue cores from UWTMA22. Shown are prostate cancer bone metastases with low to intermediate intensity in >95% of tumor cells (left) and intermediate to high intensity in >95% of tumor cells (right). B: bone. (B) Fn14 stain intensity (left panel) and extent (right panel) scores in TMA samples in different groups. *** P<0.001 vs metastasis. (C) Histological images of prostate cancer and bone metastasis sections stained for TWEAK. *: adenocarcinoma component. B: bone.
Supplementary Figure 3 from Curative Properties of Noninternalizing Antibody–Drug Conjugates Based on Maytansinoids
Authors: Perrino Elena , Steiner Martina , Krall Nikolaus , Bernardes Gonçalo J.L. , Pretto Francesca , Casi Giulio , Neri Dario
Published: April 2023

PDF file - 82KB, Supplementary figure 3: cytotoxicity data.
Supplementary Tables 1-3 from DDB2: A Novel Regulator of NF-κB and Breast Tumor Invasion
Authors: Ennen Marie , Klotz Rémi , Touche Nadège , Pinel Sophie , Barbieux Claire , Besancenot Vanessa , Brunner Emilie , Thiebaut Denise , Jung Alain C. , Ledrappier Sonia , Domenjoud Lionel , Abecassis Joseph , Plénat François , Grandemange Stéphanie , Becuwe Philippe
Published: April 2023

PDF - 86K, Supplementary Table 1: Primers for RT-PCR, ChIP analysis and EMSA. Supplementary Table 2: Data from flow cytometry analysis showing the distribution of the quantified invasive cells in lungs from mice injected with MDA Neo or DDB2 cells. Supplementary Table 3: Data from flow cytometry analysis showing the distribution of the quantified invasive cells in lungs from mice xenografted with a fragment of MDA Neo or DDB2 expressing tumor.
Supplementary Figure 5 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
Authors: Ismail Ismail Hassan , Davidson Riley , Gagné Jean-Philippe , Xu Zhi Zhong , Poirier Guy G. , Hendzel Michael J.
Published: April 2023

PDF file - 39KB, Figure S5. Effect of MG132 on BAP1 recruitment to sites of DNA damage. (A) U2OS cells expressing GFP-BAP1 were either treated with DMSO or MG132 (1 uM) for 1 hr. Cells were monitored after micro-irradiation using time-lapse microscopy. The integrated intensity in the micro-irradiated areas was determined (n = 15) and the percentage of maximum value was plotted versus time. SEM of at least two independent experiments. (B) Flow cytometer profiles of the experiment done in figure 6A and B.
Supplementary Figure 3 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
Authors: Ismail Ismail Hassan , Davidson Riley , Gagné Jean-Philippe , Xu Zhi Zhong , Poirier Guy G. , Hendzel Michael J.
Published: April 2023

PDF file - 41KB, Figure S3. Time-lapse microscopy of GFP-BAP1 after laser micro-irradiation in: (A) U2OS cells treated with DMSO or ATM specific inhibitor (ATMi)( 10 uM) for 1 hr. (B) ATM deficient cells (EBS) or ATM deficient cells reconstituted with functional ATM (YZ5). Data are average of two independent experiments (n=15). Error bars represent stand error of the SEM. (C) Inhibition of ATM activity in cells. Immunostaining of U2OS cells treated with DMSO or ATM inhibitor (ATMi) (10 uM) for 1 hr. Cells were then irradiated with 2 Gy, allowed to recover for 30 min and immunostained with gammaH2AX antibody (as an example of ATM substrate) and counterstained with DAPI to reveal DNA. Bars, 5 microm.
Supplementary Figure 2 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
Authors: Ismail Ismail Hassan , Davidson Riley , Gagné Jean-Philippe , Xu Zhi Zhong , Poirier Guy G. , Hendzel Michael J.
Published: April 2023

PDF file - 46KB, Figure S2: ChIP analysis demonstrates enrichment of GFP-BAP1 WT but not GFP-BAP1-ΔUCH across reporter locus compared to IgG control. (A) U2OS cells containing the stably integrated reporter were co-transfected with GFP alone, GFP-BAP1 WT or GFP-BAP1-ΔUCH and Fok1 constructs for 24 hr. Cells were then fixed and subjected to chromatin immunoprecipitation (ChIP) using GFP or IgG antibodies. ch7 represents negative control locus on chromosome 7. Data are from two independent experiments. SEM represent standard error of the mean. (B) Knock down of BAP1 in cells using BAP1 specific shRNA. U2OS cells were transfected with control (Ctr) or one of two different BAP1 shRNA (BAP1 shRNA 1 and BAP1 shRNA2) for 48 hr. Nuclear extracts were prepared and immunoblotting was performed using the indicated antibodies. (C) Knockdown of ASXL1 in U2OS cells. U2OS cells were transfected with control or a ASXL1 shRNA for 48 h. Nuclear extracts were prepared and immunoblotted using ASXL1 and BAP1 antibodies. Actin was used as a loading control. (D) Association of BAP1 and ASXL1 is not altered in response to DNA damage. U2OS cells were left untreated or exposed to radiation (6 Gy) and allowed to recover for 2 hr. Nuclear extracts were prepared and immunoprecipitation was conducted with BAP1 or ASXL1 antibodies. Flow through (FT) and elute (El) and 20% of the input was immunoblotted as indicated.
Supplementary Tables 1 through 7 from The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression
Authors: Sonabend Adam M. , Bansal Mukesh , Guarnieri Paolo , Lei Liang , Amendolara Benjamin , Soderquist Craig , Leung Richard , Yun Jonathan , Kennedy Benjamin , Sisti Julia , Bruce Samuel , Bruce Rachel , Shakya Reena , Ludwig Thomas , Rosenfeld Steven , Sims Peter A. , Bruce Jeffrey N. , Califano Andrea , Canoll Peter
Published: April 2023

XLSX - 1231K, Supplementary Table 1: List of genes deleted in 75 to 100% of the end-stage *PTEN tumors Supplementary Table 2: List of genes showing copy number gains in *PTEN end-stage and *PTEN/p53 mouse tumors. Supplementary Table 3: Genes that were deleted in 75-100% of *PTEN end-stage mouse tumors and at least 10% of human tumors within one of the four GBM subtypes mapped to their chromosomal location in the human genome. Supplementary Table 4: List of gene deletions that were specific for one of the four GBM subtypes. Supplementary Table 5: Correlation of proneural-specific genetic alterations and deletions identified by cross-species comparison. Supplementary Table 6: Spearman correlation for Verhaak gene sets show highest correlation for human proneural GBM subtype for 21 dpi *PTEN tumors, end-stage *PTEN tumors and *p53 end-stage tumors. Supplementary Table 7: MR identified from NB versus *PTEN 21 dpi and NB versus *PTEN end-stage mouse MARINas, and human NB versus proneural GBM (TCGA) MARINa.
Supplementary Figure 1 from Invasive Lobular Carcinoma Cell Lines Are Characterized by Unique Estrogen-Mediated Gene Expression Patterns and Altered Tamoxifen Response
Authors: Sikora Matthew J. , Cooper Kristine L. , Bahreini Amir , Luthra Soumya , Wang Guoying , Chandran Uma R. , Davidson Nancy E. , Dabbs David J. , Welm Alana L. , Oesterreich Steffi
Published: April 2023

PDF file - 53K, E2 regulation of ER target genes in ILC cells.
Supplementary Tables 1 - 2 from HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer
Authors: Rath Kellie S. , Naidu Shan K. , Lata Pushpa , Bid Hemant K. , Rivera Brian K. , McCann Georgia A. , Tierney Brent J. , ElNaggar Adam C. , Bravo Veronica , Leone Gustavo , Houghton Peter , Hideg Kálmán , Kuppusamy Periannan , Cohn David E. , Selvendiran Karuppaiyah
Published: April 2023

PDF file - 95K, Results of Tukey's post-hoc test and Molecular weights of the pure DAP compounds.
Supplementary Methods from Identification of Alternative Splicing Events Regulated by the Oncogenic Factor SRSF1 in Lung Cancer
Authors: de Miguel Fernando J. , Sharma Ravi D. , Pajares María J. , Montuenga Luis M. , Rubio Angel , Pio Ruben
Published: April 2023

PDF file - 96K, Description of the ExonPointer algorithm.
Supplementary Figure 6 from HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer
Authors: Rath Kellie S. , Naidu Shan K. , Lata Pushpa , Bid Hemant K. , Rivera Brian K. , McCann Georgia A. , Tierney Brent J. , ElNaggar Adam C. , Bravo Veronica , Leone Gustavo , Houghton Peter , Hideg Kálmán , Kuppusamy Periannan , Cohn David E. , Selvendiran Karuppaiyah
Published: April 2023

PDF file - 692K, (A) H-4073 Cell uptake in A2780 and CHO cell lines; (B) Ion chromatogram of pure HO-3867 in A2780 cells; (C) Ion chromatogram of pure HO-3867 in CHO cells; (D) Extracted ion chromatograms - H-4073; (E)Extracted ion chromatograms - H-4073.
Supplementary Figure 11 from Accumulation of Cytosolic Calcium Induces Necroptotic Cell Death in Human Neuroblastoma
Authors: Nomura Motonari , Ueno Ayumi , Saga Kotaro , Fukuzawa Masahiro , Kaneda Yasufumi
Published: April 2023

PDF - 130K, Increased cytoplasmic Ca2+ induces necroptosis in SK-N-SH cells.
Supplementary Figure 1 from Accumulation of Cytosolic Calcium Induces Necroptotic Cell Death in Human Neuroblastoma
Authors: Nomura Motonari , Ueno Ayumi , Saga Kotaro , Fukuzawa Masahiro , Kaneda Yasufumi
Published: April 2023

PDF - 86K, Cell fusion is not the main cause of HVJ-E-induced cell death.
Supplementary Figure 1 from Activation of the FGFR–STAT3 Pathway in Breast Cancer Cells Induces a Hyaluronan-Rich Microenvironment That Licenses Tumor Formation
Authors: Bohrer Laura R. , Chuntova Pavlina , Bade Lindsey K. , Beadnell Thomas C. , Leon Ronald P. , Brady Nicholas J. , Ryu Yungil , Goldberg Jodi E. , Schmechel Stephen C. , Koopmeiners Joseph S. , McCarthy James B. , Schwertfeger Kathryn L.
Published: April 2023

PDF file - 66K, IHC control images.
Supplementary Figure 3 from Expression of Variant Isoforms of the Tyrosine Kinase SYK Determines the Prognosis of Hepatocellular Carcinoma
Authors: Hong Jian , Yuan Yunfei , Wang Jianping , Liao Yadi , Zou Ruhai , Zhu Chuanlong , Li Binkui , Liang Yi , Huang Pinzhu , Wang Zongwei , Lin Wenyu , Zeng Yixin , Le Dai Jia , Chung Raymond T.
Published: April 2023

PDF file - 166KB, Supplementary Figure 3. Effects of suppressed expression of SYK(L) or SYK(S) on cell proliferation and invasion in Huh7 SYK(L)-positive (A), MHCC-97H both SYK(L) and SYK(S)-positive (B), and SMMC7721 cells ectopically expressing SYK(L) (C) or SYK(S) (D).
Supplementary Figure Legend from Metastatic Growth Progression Caused by PSGL-1–Mediated Recruitment of Monocytes to Metastatic Sites
Authors: Hoos Alexandra , Protsyuk Darya , Borsig Lubor
Published: April 2023

PDF file - 104K
Supplementary Figure 4 from Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392
Authors: De Bellis Floriana , Carafa Vincenzo , Conte Mariarosaria , Rotili Dante , Petraglia Francesca , Matarese Filomena , Françoijs Kees-Jan , Ablain Julien , Valente Sergio , Castellano Rèmy , Goubard Armelle , Collette Yves , Mandoli Amit , Martens Joost H.A. , de Thé Hugues , Nebbioso Angela , Mai Antonello , Stunnenberg Hendrik G. , Altucci Lucia
Published: April 2023

PDF file - 91KB, Death pathways modulation by MC2392.
Data Supplement from Mitochondrial Retrograde Signaling Mediated by UCP2 Inhibits Cancer Cell Proliferation and Tumorigenesis
Authors: Esteves Pauline , Pecqueur Claire , Ransy Céline , Esnous Catherine , Lenoir Véronique , Bouillaud Frédéric , Bulteau Anne-Laure , Lombès Anne , Prip-Buus Carina , Ricquier Daniel , Alves-Guerra Marie-Clotilde
Published: April 2023

Table S1. UCP2 mRNA levels in different cancers (Oncomine data)
Supplementary Tables 1-5 from PDGFRα and β Play Critical Roles in Mediating Foxq1-Driven Breast Cancer Stemness and Chemoresistance
Authors: Meng Fanyan , Speyer Cecilia L. , Zhang Bin , Zhao Yongzhong , Chen Wei , Gorski David H. , Miller Fred R. , Wu Guojun
Published: April 2023

Supplementary Tables 1-5. Supplementary Table 1: Sequences of shRNAs used to knock down target genes Supplementary Table 2: Sequences of PCR primers used in RT-PCR and QRT-PCR Supplementary Table 3: Representative genes up- or down-regulated by Foxq1 Supplementary Table 4: Consensus binding sequences of three transcription factors Supplementary Table 5: Sequences of PCR primers used in ChIP-qPCR
Supplementary Figure 2 from TGF-β Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment
Authors: Yeung Tsz-Lun , Leung Cecilia S. , Wong Kwong-Kwok , Samimi Goli , Thompson Melissa S. , Liu Jinsong , Zaid Tarrik M. , Ghosh Sue , Birrer Michael J. , Mok Samuel C.
Published: April 2023

PDF file, 193K, Immunostaining of ovarian tissue sections for TGF-B receptor type 1 and 2.
Supplementary Experimental Procedures from TGF-β Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment
Authors: Yeung Tsz-Lun , Leung Cecilia S. , Wong Kwong-Kwok , Samimi Goli , Thompson Melissa S. , Liu Jinsong , Zaid Tarrik M. , Ghosh Sue , Birrer Michael J. , Mok Samuel C.
Published: April 2023

PDF file, 97K.
Supplemental Figure S2 from Cytokine-like Molecule CCDC134 Contributes to CD8+ T-cell Effector Functions in Cancer Immunotherapy
Authors: Huang Jing , Xiao Lin , Gong Xiaoting , Shao Wenwei , Yin Yanhui , Liao Qinyuan , Meng Yang , Zhang Yingmei , Ma Dalong , Qiu Xiaoyan
Published: April 2023

CCDC134 has no apparent effect on activation, effector function and proliferation of mouse CD4+ T cells.
Supplementary Materials and Methods from HDAC2 Provides a Critical Support to Malignant Progression of Hepatocellular Carcinoma through Feedback Control of mTORC1 and AKT
Authors: Noh Ji Heon , Bae Hyun Jin , Eun Jung Woo , Shen Qingyu , Park Se Jin , Kim Hyung Seok , Nam Boas , Shin Woo Chan , Lee Eun Kyung , Lee Kyungbun , Jang Ja-Jun , Park Won Sang , Lee Jung Young , Nam Suk Woo
Published: April 2023

PDF file - 155KB
Supplementary Figure 4 from BRCA2 Phosphorylated by PLK1 Moves to the Midbody to Regulate Cytokinesis Mediated by Nonmuscle Myosin IIC
Authors: Takaoka Miho , Saito Hiroko , Takenaka Katsuya , Miki Yoshio , Nakanishi Akira
Published: April 2023

PDF file - 148K, BRCA1 gene silencing had no influence on the formation of midbody. (Related to Figure 3).
Supplemental Methods, Data 1 - 8 from Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma
Authors: Koh Mei Yee , Nguyen Vuvi , Lemos Robert , Darnay Bryant G. , Kiriakova Galina , Abdelmelek Mena , Ho Thai H. , Karam Jose , Monzon Federico A. , Jonasch Eric , Powis Garth
Published: April 2023

Supplemental methods. A, B) Sequences for the A) P117 Luc, and B) P117 HRE reporters containing the HAF binding site, the hypoxia responsive element (HRE) and the HIF ancillary sequence (HAS), with the restriction enzyme sites used for ligation into the pGL4.17 construct. C) PCR primers used in ChIP assays. Supplementary data S1. A) Quantitative TaqMan RT-PCR showing the effect of transient HAF overexpression on the transcription of HIF-2 target genes in pVHL-deficient A498 CRCC cells B) Quantitative TaqMan RT-PCR showing the effect of transient HAF overexpression on the transcription of OCT-3/4. SOX2 and NANOG in normoxia and 24hours' hypoxia in A498 CRCC cells. Supplementary data S2. A) Effects of HAF overexpression on luciferase activity of co-transfected P117 Luc or P117 containing a deletion of the HAF site (P117D), in PANC1 cells in normoxia. B) Western blot showing knockdown specificity of siRNAs targeting HIF-2α (siH2_1, siH2_2) or HAF (siHAF_1, siHAF_2) when transfected with the P117 reporter in 786-0 cells. Supplementary data S3. A) Effect of hypoxia on SUMO-2/3 modification of HAF in 786-0 cells. B) Effect of hypoxia on SUMO-1 modification of HAF in PANC-1 cells. C) Western blot showing immunoprecipitation of HIF-2α from lysates of PANC-1 cells. Supplementary data S4. A-B) Immunocytochemistry confirming specificities of A) HAF, and B) HIF-2α antibodies. Supplementary data S5. A) Growth curve of HAF overexpressing 786-0 cells in normoxia. B) Western blot showing GFP expression in suspected lesions observed in the GI tracts of mice bearing renal orthotopic 786-0 HAF or vector expressing CRCC cells. Supplementary data S6. A) Table showing multiple disease parameters of the patients represented on the CRCC TMA. B) Scatterplot showing correlation between nuclear and cytoplasmic HAF localization in CRCC TMA. Supplementary data S7. Kaplan-Meier curves showing relationship between good versus intermediate Motzer criteria in grade III/IV CRCC. Supplementary data S8. A-B) Kaplan-Meier curves showing relationships between levels of A) HIF-2α or B) HIF-1α and progression free survival (PFS) in grade III/IV CRCC.
Supplementary Movie 5 from Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer
Authors: Thadani-Mulero Maria , Portella Luigi , Sun Shihua , Sung Matthew , Matov Alexandre , Vessella Robert L. , Corey Eva , Nanus David M. , Plymate Stephen R. , Giannakakou Paraskevi
Published: April 2023

AVI file - 956KB, Dynamics of ARv7 variant nuclear accumulation in cells treated with 10nM Noc.
Supplementary Figure 2 from Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer
Authors: Thadani-Mulero Maria , Portella Luigi , Sun Shihua , Sung Matthew , Matov Alexandre , Vessella Robert L. , Corey Eva , Nanus David M. , Plymate Stephen R. , Giannakakou Paraskevi
Published: April 2023

PDF file - 152KB, Antibody detection of AR in M12 series.
Supplementary Movie 3 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

MP4 file - 3337K, Supplementary movie S3: time-lapse video-microscopy with a 10x magnification objective, of Lu1205 cells plated on plastic 48 hr after MOCK transfection.
Supplementary Figure 6 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: April 2023

PDF file - 365K, Figure. S6. VHL inhibit HIF-2a and VEGF expression independent AR.
Supplementary Video 1 from miR-28-5p Promotes Chromosomal Instability in VHL-Associated Cancers by Inhibiting Mad2 Translation
Authors: Hell Michael P. , Thoma Claudio R. , Fankhauser Niklaus , Christinat Yann , Weber Thomas C. , Krek Wilhelm
Published: April 2023

MOV file - 701KB, Suppl. Movie 1: Analysis of nocodazole-induced mitotic arrest in HeLa cells. Time-lapse (5 min interval, total time: 14h) movies of nocodazole-arrested HeLa H2B-GFP cells transfected with siCtrl.
Supplementary Figure 5 from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: April 2023

Supplementary Figure 5. This figure shows nucleosome positioning around 2 genes downregulated after Brg1 KD.
Supplemental Methods and References,Supplementary Figures S1-S3, and Supplementary Table S1 from RHPN2 Drives Mesenchymal Transformation in Malignant Glioma by Triggering RhoA Activation
Authors: Danussi Carla , Akavia Uri David , Niola Francesco , Jovic Andreja , Lasorella Anna , Pe'er Dana , Iavarone Antonio
Published: April 2023

Supplemental Methods and References. Figure S1. Illustration of Module generation Figure S2. CNV and Expression of RHPN2 in GBM samples from TCGA and Rembrandt databases. Figure S3. Western Blot and qPCR of RHPN2 in different cell lines. Table S1. List of Primers
Supplementary Figure 3 from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: April 2023

Supplementary Figure 3. This figure shows additional characterization of nucleosome positioning positions changes around transcription start sites in Brg1 KD cell lines.
Supplementary Figures S1-S7 from Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b
Authors: Shiah Shine-Gwo , Hsiao Jenn-Ren , Chang Wei-Min , Chen Ya-Wen , Jin Ying-Tai , Wong Tung-Yiu , Huang Jehn-Shyun , Tsai Sen-Tien , Hsu Yuan-Ming , Chou Sung-Tau , Yen Yi-Chen , Jiang Shih Sheng , Shieh Yi-Shing , Chang I-Shou , Hsiao Michael , Chang Jang-Yang
Published: April 2023

Supplementary Figures S1-S7. Supplementary Figure S1: Genome-wide profiling of chromosome 14q32.2 miRNA on OSCC tissues. Supplementary Figure S2: Mi-RNA level in miR-PM overexpressed OEC-M1 and SCC-15 cells. Supplementary Figure S3: Effect of miR-329 and miR-410 on Wnt/ÃŽÂ²-catenin signaling pathway. Supplementary Figure S4: The effects of miR-329 and miR-410 on tumor cell proliferation. Supplementary Figure S5: Expression level of miRNA in xenograft tumor tissue. Supplementary Figure S6: Effects of miR-329 and -410 on tumorigenicity. Supplementary Figure S7: Effects of arecoline on Wnt/ÃŽÂ²-catenin signaling pathway.
Data Supplement from A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer
Authors: Zhao Yu , Yang Yihua , Trovik Jone , Sun Kun , Zhou Liang , Jiang Peiyong , Lau Tat-San , Hoivik Erling A. , Salvesen Helga B. , Sun Hao , Wang Huating
Published: April 2023

Supplemental Dataset. RNAseq analysis results of PCDH10 overexpressing HEC-1-B cells.
Supplementary Figure S3 from BET Protein Inhibitor JQ1 Attenuates Myc-Amplified MCC Tumor Growth In Vivo
Authors: Shao Qiang , Kannan Aarthi , Lin Zhenyu , Stack Brendan C. , Suen James Y. , Gao Ling
Published: April 2023

Supplementary Figure S3. JQ1 exerts no effect on mTOR pathway and MCC cells express characteristic MCC makers, including a Merkel cell specific transcription factor Math1.
Supplementary Figure Legend from BET Protein Inhibitor JQ1 Attenuates Myc-Amplified MCC Tumor Growth In Vivo
Authors: Shao Qiang , Kannan Aarthi , Lin Zhenyu , Stack Brendan C. , Suen James Y. , Gao Ling
Published: April 2023

Supplementary Figure Legend. Legend for Supplementary Figures S1-S4.
Supplementary Figure S7 from PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer
Authors: Yao Ruosi , Jiang Hao , Ma Yuhui , Wang Liping , Wang Lin , Du Juan , Hou Pingfu , Gao Yanyan , Zhao Li , Wang Guannan , Zhang Yu , Liu Dong-Xu , Huang Baiqu , Lu Jun
Published: April 2023

Effect of PRMT7 on YY1 protein expression, and the interplay between YY1 and HDAC3.
Data Supplement from Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks
Authors: Colvin Teresa A. , Gabai Vladimir L. , Gong Jianlin , Calderwood Stuart K. , Li Hu , Gummuluru Suryaram , Matchuk Olga N. , Smirnova Svetlana G. , Orlova Nina V. , Zamulaeva Irina A. , Garcia-Marcos Mikel , Li Xiaokai , Young Z.T. , Rauch Jennifer N. , Gestwicki Jason E. , Takayama Shinichi , Sherman Michael Y.
Published: April 2023

Supplemental Figure S2. Effect of Hsp70 or Bag3 depletion in HCT116 cells on signaling pathways.
Data Supplement from Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks
Authors: Colvin Teresa A. , Gabai Vladimir L. , Gong Jianlin , Calderwood Stuart K. , Li Hu , Gummuluru Suryaram , Matchuk Olga N. , Smirnova Svetlana G. , Orlova Nina V. , Zamulaeva Irina A. , Garcia-Marcos Mikel , Li Xiaokai , Young Z.T. , Rauch Jennifer N. , Gestwicki Jason E. , Takayama Shinichi , Sherman Michael Y.
Published: April 2023

Description of additional methods and procedures used in the study.
Supplementary Figure 6 from Flotillin-1 Regulates Oncogenic Signaling in Neuroblastoma Cells by Regulating ALK Membrane Association
Authors: Tomiyama Arata , Uekita Takamasa , Kamata Reiko , Sasaki Kazuki , Takita Junko , Ohira Miki , Nakagawara Akira , Kitanaka Chifumi , Mori Kentaro , Yamaguchi Hideki , Sakai Ryuichi
Published: April 2023

PDF file - 236KB, Supplementary figure S6. FLOT1 regulates ALK expression and activation as well as oncogenicity by regulating ALK-endocytosis in Nagai neuroblastoma cells harboring amplified wild-type ALK.
Supplementary Figure S5 from Efficacy of CAR T-cell Therapy in Large Tumors Relies upon Stromal Targeting by IFNγ
Authors: Textor Ana , Listopad Joanna J. , Wührmann Lara Le , Perez Cynthia , Kruschinski Anna , Chmielewski Markus , Abken Hinrich , Blankenstein Thomas , Charo Jehad
Published: April 2023

Non-hematopoietic cells compose the majority of the SKOV3 tumor stroma
Supplementary Figure 5 from miR326 Maturation Is Crucial for VEGF-C–Driven Cortactin Expression and Esophageal Cancer Progression
Authors: Hong Chih-Chen , Chen Pai-Sheng , Chiou Jean , Chiu Ching-Feng , Yang Ching-Yao , Hsiao Michael , Chang Yi-Wen , Yu Yang-Hao , Hung Mien-Chie , Hsu Nai-Wen , Shiah Shine-Gwo , Hsu Nan-Yung , Su Jen-Liang
Published: April 2023

Supplementary Figure 5. The mRNA expression of Dicer between TE-1/VEGF-C and TE-1/vector cells. TE-1 cells were stably expressed VEGF-C or vector control and isolated total RNA to assay. qRT-PCR was used to quantify the expression level of Dicer, and the quantities values were evaluated as percentage compared with TE-1/vector cells. The columns are the mean values from three independent experiments. Bars indicate means {plus minus} SE.
Data Supplement from A Search for Novel Cancer/Testis Antigens in Lung Cancer Identifies VCX/Y Genes, Expanding the Repertoire of Potential Immunotherapeutic Targets
Authors: Taguchi Ayumu , Taylor Allen D. , Rodriguez Jaime , Çeliktaş Müge , Liu Hui , Ma Xiaotu , Zhang Qing , Wong Chee-Hong , Chin Alice , Girard Luc , Behrens Carmen , Lam Wan L. , Lam Stephen , Minna John D. , Wistuba Ignacio I. , Gazdar Adi F. , Hanash Samir M.
Published: April 2023

Supplementary Table S2. mRNA expression levels (log2 intensity) of 182 CT antigens in 38 NSCLC cell lines.
Data Supplement from Analysis of Chemotherapeutic Response in Ovarian Cancers Using Publicly Available High-Throughput Data
Authors: Bosquet Jesus Gonzalez , Marchion Douglas C. , Chon HyeSook , Lancaster Johnathan M. , Chanock Stephen
Published: April 2023

Multivariate analysis of clinical factors affecting survival in TCGA database ; Differentially expressed genes between patients with complete response (CR) and patients with incomplete response (IR) in the 3 clinical databases (GSE9891, TCGA, GSE23554) and in OVCA cell lines after in vitro chemo-sensitivity analysis ; Representation of genomic somatic gains and losses determined by the genomic identification of significant targets in cancer (GISTIC) analysis ; TCGA analyses of gene expression, mutations, DNA methylation and miRNA expression between CR samples and IR samples ; Validation of TCGA gene expression signature in independent available databases ; Transcription factor (TF) binding site analysis ; Detail of level of agreement (kappa coefficient) for placement of an individual gene in the same cluster than in TCGA analysis represented in contingency tables .
Data Supplement from Analysis of Chemotherapeutic Response in Ovarian Cancers Using Publicly Available High-Throughput Data
Authors: Bosquet Jesus Gonzalez , Marchion Douglas C. , Chon HyeSook , Lancaster Johnathan M. , Chanock Stephen
Published: April 2023

Whole genome regions with copy number gain/loss were included
; All genes with CNA affecting candidate pathway genes and statistically significant positive correlation (p-value <10-4, qFDR <10-4) with gene expression are represented (N = 2,364) ; Gene expression signature predictive of complete response (CR) versus incomplete response (IR) using the CNA-Correlated-Pathway (CCP) gene subset ; Differentially methylated genes between the CR and IR groups ; Differentially expressed miRNA between the CR and IR groups ; Differentially expressed genes (CR versus IR) from the 1,772 genes identified to have TF binding sites within the CNA-Correlated-Pathway (CCP) gene subset ; 422 significant genes included in the final model or signature ; Pathways and biological processes identified with the software for enrichment analysis GeneGo. These pathways were overrepresented in cluster #1 of the NMF consensus clustering ; Pathways and biological processes identified with the software for enrichment analysis GeneGo. These pathways overrepresented in cluster #2 of the NMF consensus clustering .
Supplementary Video #7 from Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform
Authors: Wong Andrew D. , Searson Peter C.
Published: April 2023

An HMVEC vessel under shear stress (12-15 dyne cm-2) extending an angiogenic sprout towards a cluster of MDA-MB-231 breast cancer cells.
Supplementary Figure S10 from CtBP2 Modulates the Androgen Receptor to Promote Prostate Cancer Progression
Authors: Takayama Ken-ichi , Suzuki Takashi , Fujimura Tetsuya , Urano Tomohiko , Takahashi Satoru , Homma Yukio , Inoue Satoshi
Published: April 2023

Supplementary Figure S10. Association of CtBP2 binding sites with CtBP2 regulated genes.
Supplemental Material and Methods from Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer
Authors: Tran Hung D. , Luitel Krishna , Kim Michael , Zhang Kun , Longmore Gregory D. , Tran David D.
Published: April 2023

Supplemental Material and Methods. Additional description of materials and methods used
Supplemental Figure S3 from Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer
Authors: Tran Hung D. , Luitel Krishna , Kim Michael , Zhang Kun , Longmore Gregory D. , Tran David D.
Published: April 2023

Supplemental Figure S3. Related to Figure 2F-J: SNAIL1 expression in primary breast tumors correlates with increased invasion
Figure S3. Elevated levels of reactive oxygen species are responsible for cell death in Tsc2-/- MEFs from mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress
Authors: Li Jing , Shin Sejeong , Sun Yang , Yoon Sang-Oh , Li Chenggang , Zhang Erik , Yu Jane , Zhang Jianming , Blenis John
Published: April 2023

Glutathione measurement in Tsc2-/- cells treated with indicated compounds; GSH/GSSH measurement in Tsc2-/- MEFs
Supplementary Figure 3 from A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Authors: Fujimura Ken , Wright Tracy , Strnadel Jan , Kaushal Sharmeela , Metildi Cristina , Lowy Andrew M. , Bouvet Michael , Kelber Jonathan A. , Klemke Richard L.
Published: April 2023

Contains additional data on in vitro and in vivo growth of PDAC cells with eIF5A knockdown or overexpression.
Supplementary Figure Legends from EGFR Blockade Enriches for Lung Cancer Stem–like Cells through Notch3-Dependent Signaling
Authors: Arasada Rajeswara Rao , Amann Joseph M. , Rahman Mohammad A. , Huppert Stacey S. , Carbone David P.
Published: April 2023

Supplementary Figure legends
Supplementary Figure 1 from A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Authors: Fujimura Ken , Wright Tracy , Strnadel Jan , Kaushal Sharmeela , Metildi Cristina , Lowy Andrew M. , Bouvet Michael , Kelber Jonathan A. , Klemke Richard L.
Published: April 2023

Contains additional biochemical and immunohistochemical data.
Supplementary Video 3 from Deubiquitination of γ-Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells
Authors: Zarrizi Reihaneh , Menard Julien Albert , Belting Mattias , Massoumi Ramin
Published: April 2023

Live cell microscopy of MDA-MB-468 inducibly expressing empty expression plasmid and transiently transfected with H2B-GFP. The movie shows anaphase bridge.
Supplemental Table S1 from Targeting Cancer Stem–like Cells as an Approach to Defeating Cellular Heterogeneity in Ewing Sarcoma
Authors: Cornaz-Buros Sandrine , Riggi Nicolo , DeVito Claudio , Sarre Alexandre , Letovanec Igor , Provero Paolo , Stamenkovic Ivan
Published: April 2023

Supplemental Table S1. Target genes of 5 TARBP2-dependent miRNAs.
Supplementary Methods from Deubiquitination of γ-Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells
Authors: Zarrizi Reihaneh , Menard Julien Albert , Belting Mattias , Massoumi Ramin
Published: April 2023

Supplementary materials and methods.
Data Supplement from Validation and Structural Characterization of the LEDGF/p75–MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia
Authors: Čermáková Kateřina , Tesina Petr , Demeulemeester Jonas , El Ashkar Sara , Méreau Hélène , Schwaller Juerg , Řezáčová Pavlína , Veverka Vaclav , De Rijck Jan
Published: April 2023

Supplementary Figures S1-S9. Published structure of the MLL-MENIN-LEDGF/p75 complex (S1); Characterization of the murine MLL-AF9 AML model (S2); Coomassie stained SDS-PAGE gels of recombinant proteins used in this study (S3); Identification of the MLL-LEDGF/p75 interaction surface (S4); Protein melting curves of LEDGF/p75 mutants (S5); Model of the MLL-MENIN-LEDGF/p75 ternary interface (S6); Representation of the buried surface area of IBD amino acid residues upon binding either MLL or HIV-1 integrase (S7); A MLL interaction deficient LEDGF/p75 mutant cannot rescue MLL-AF9 transformation upon LEDGF/p75 knockdown (S8); CP65 interferes with LEDGF/p75-MLL but not with MENIN-MLL complex formation in vitro (S9).
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: April 2023

Supplementary Figure S5. Morphometric analysis of 48hr post-implantation intracranial GL26-Cit gliomas (shown in Figure 1G).
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: April 2023

Supplementary Figure S6. Validating immunodepletion of NK cells and basophils in RAG1-/- mice.
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Authors: von Roemeling Christina A. , Radisky Derek C. , Marlow Laura A. , Cooper Simon J. , Grebe Stefan K. , Anastasiadis Panagiotis Z. , Tun Han W. , Copland John A.
Published: April 2023

Supplementary Figure 2. (A) IF of non-permeabilized KIJ265T cells for NPTX2 expression. (B) Relative NPTX2 expression values of patient gene array data sorted into low versus high NPTX2 expression groups. (C) IF for NPTX2 (far left panel) and Fibronectin (far right panel) in A498 NT vs. sh1316 NPTX2 knockdown cells. 60x magnification of regions highlighted in 20x images are shown (central panels).
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: April 2023

Legend for Supplementary Figures S1-S8.
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Authors: von Roemeling Christina A. , Radisky Derek C. , Marlow Laura A. , Cooper Simon J. , Grebe Stefan K. , Anastasiadis Panagiotis Z. , Tun Han W. , Copland John A.
Published: April 2023

Supplementary Figure 4. Measurement of intracellular calcium influx into (A) empty vector or (B) GluR4 transfected Caki1 cells treated with 1ng/µL R-NPTX2 and DMSO or CFM-2 (10µM) over time using the cell permeable fluorescently labeled calcium indicator Calcium GreenTM-1, AM. Results are calculated as change in fluorescence over time (min). (*) Denotes significant change in fluorescence as compared to DMSO control per time point, and (**) denotes a significant change between R-NPTX2 +/- CFM-2 treated cells. (C) Intracellular Ca2+ levels of NPTX2 and NPTX2-GluR4 transfected Caki1 cells pretreated for 1 hour with DMSO or specified doses of CFM-2. (*) Denotes a significant change in fluorescence of NPTX2 and NPTX2-GluR4 as compared to EV control, and (**) indicates significant changes in fluorescence between DMSO and CFM-2 treated groups
Supplemental Figure 2. Cerenkov Light Images of excised organs. from In Vivo Localization of 90Y and 177Lu Radioimmunoconjugates Using Cerenkov Luminescence Imaging in a Disseminated Murine Leukemia Model
Authors: Balkin Ethan R. , Kenoyer Aimee , Orozco Johnnie J. , Hernandez Alexandra , Shadman Mazyar , Fisher Darrell R. , Green Damian J. , Hylarides Mark D. , Press Oliver W. , Wilbur D. Scott , Pagel John M.
Published: April 2023

Supplemental Figure 2. Cerenkov Light Images of excised organs. Groups of 5 mice were given 300 µCi on 100 µg of 90Y-DOTA-30F11 (A), 177Lu-DOTA-30F11 (B), 90Y-DOTA-Rat IgG (C), or 177Lu-DOTA-Rat IgG (D). Groups of mice were harvested and images collected at 4, 24, 48, and 72 hours post-injection, immediately prior to gamma counting of the tissues. By 24 hours post-injection, there was little or no detectable signal in non-target organs and tissues.
Supporting Data from Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Authors: Tao Shasha , Wang Shue , Moghaddam Seyed Javad , Ooi Aikseng , Chapman Eli , Wong Pak K. , Zhang Donna D.
Published: April 2023

Supporting Data. Supporting reference, Supporting Figure Legends and Supporting Materials and Methods
Supplementary Table S8 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: April 2023

Intersecting top 5% of mutated genes based on the proportion of affected samples between CRC cell lines and TCGA-analyzed primary cancers for non-hypermutated and hypermutated MSI-H samples.
Supplementary Table S5 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: April 2023

Significantly altered focal regions of chromosomal deletion or gain/amplification for 63 unique CRC cell lines and 213 TCGA-analyzed primary cancers stratified into non-hypermutated and hypermutated MSI-H cases. Minimal focal regions were deduced using OncoSNP v2.18 suite and GISTIC2.0.