bluuebunny/crossref_metadata_2025 huggingface dataset:
Sarcopenic phenotype and functional status of skeletal muscles in rheumatoid arthritis patients with biological therapy
Authors: Dobrovolskaya O. V. , Demin N. V. , Feklistov A. Yu. , Kozyreva M. V. , Toroptsova N. V.
Published: October 2023

Aim. To evaluate skeletal muscle mass, muscle strength and physical performance in rheumatoid arthritis (RA) women with biological therapy.

Materials and methods. The study included 63 women (average age 60.3 ± 8.9 years) with confirmed RA treated with biological therapy and 117 age-matched RA patients who had never previously treated with biological therapy. Clinical and laboratory examination, evaluation of body composition using dual-energy X-ray densitometry and tests to assess muscle strength and physical performance were carried out.

Results. The frequency of sarcopenic phenotype among RA patients was 23.3 %: in those who received biological medication – 27.0 %, in the control – 21.4 % (p > 0.05). There were no differences between the groups based on the results of muscle strength assessment tests, however, patients on biological therapy performed significantly better the short physical performance battery (SPPB) and had a higher walking speed (p = 0.016 and p = 0.002, respectively). Univariate linear regression analysis confirmed the relationship of the presence of biological therapy with the functional status of the muscles according to the results of SPPB (b* = 0.24; p = 0.018) and walking speed (b* = 0.28; p = 0.006).

Conclusion. The frequency of sarcopenic phenotype among patients with RA was 23.3 % and was comparable in those who received biological therapy and without it. There were no differences in muscle strength depending on the presence of biological therapy, but the functional status of skeletal muscles was significantly better in women who received such treatment.
Gender specifics of affective disorders in patients with coronary heart diseas (according to screening and psychometric tests)
Authors: Mukhtarenko S. Yu. , Murataliev T. M. , Rajapova Z. T.
Published: October 2023

Aim. To study gender characteristics of affective disorders (prevalence and severity of anxiety and depression) and quality of life in patients with coronary heart disease (CHD) according to screening and psychometric tests.

Materials and methods. Five hundred seventy six patients with a verified diagnosis of CHD were tested using the Screening Questionnaire for Affective Spectrum Disorders (SQASD): 385 (67.8 %) men and 191 (33.2 %) women. From the total screening group using, 383 patients were examined with the Beck Depression Inventory (BDI), while examination with the hospital anxiety and depression scale (HADS) included 351 patients with CHD. The quality of life index was determined in 242 patients with CHD using the Modified Seattle Angina Questionnaire (SAQ).

Results. In the general group of patients with CHD examined by SQASD, anxiety and depressive disorders (ADD) were diagnosed in 81 %, the absence of ADD – in 19 %, p < 0.0001. In the group of patients examined using SQASD and the BDI scale, the presence of ADD was noted in 78.9 %, the absence – in 21.1 %, p < 0.0001. Screening of patients examined with the BDI scale revealed higher incidence of ADD in women: 95 % vs. 71.5 %, p < 0.0001. The overall score on the HADS anxiety scale in the men’s group was 7.9 ± 4.7, in the women’s group – 10.28 ± 3.9, p < 0.0001, while according the HADS depression scale – 6.32 ± 3.92 and 7.7 ± 4.18, respectively, p < 0.004. The level of depression by BDI scale in the men’s group was 14.07 ± 9.82, in the women’s group – 17.75 ± 8.42, p < 0.0004. Absence of symptoms of depression according the BDI scale was observed more often in the group of men compared with the group of women: 36.9 % and 19.2 %, p < 0.0005. The frequency of severe anxiety (45.8 % and 28.7 %, p < 0.002) and depression (26.2 % and 11.5 %, p < 0.0004) according the HADS was higher in the group of women compared to the group of men. The value of the IUCN quality of life index was higher in the group of men (25.4 ± 7.1 and 22.4 ± 4.8, p < 0.001).

Conclusion. In this study, screening of CHD patients using SQASD and psychometric tests (BDI and HADS) has revealed higher incidence of ADD and psychosocial risk factors (anxiety and depression) in the group of women compared with the group of men. The results of screening are generally consistent with the survey data of psychometric tests and QOL indicators.
TÜRKİYE’DEKİ SURİYELİ KADINLARA SİVİL TOPLUM ÖRGÜTLERİ TARAFINDAN SUNULAN HİZMETLERİN SOSYAL ÇALIŞMA MÜDAHALE SÜRECİ BAĞLAMINDA DEĞERLENDİRİLMESİ: BİR ÖRNEK OLAY
Authors: AKKUŞ Pınar
Published: October 2023

Bu çalışmada Türkiye’deki Suriyeli kadınlara sivil toplum örgütleri (STÖ) tarafından sunulan sosyal hizmetler bir örnek olay üzerinden değerlendirilmiştir. Bu nitel araştırmada Türkiye’deki STÖ’lerden destek alan Suriyeli bir kadın mültecinin sosyal çalışma müdahale süreci ele alınarak kendisi ve ona sosyal hizmet sunan 7 STÖ servis sağlayıcısı ile derinlemesine görüşmeler yapılmıştır. Araştırmanın geçerliliğini, güvenilirliğini sağlayabilmek adına Suriyeli kadın mülteciden elde edilen sonuçlarla servis sağlayıcılardan elde edilen sonuçlar ve görüşmelerden elde edilen sonuçlarla dokümanlardan elde edilen sonuçlar birbiriyle karşılaştırılmış ve araştırmanın sonuçları vaka yöneticisinin kontrolünden geçirilmiştir. Derinlemesine görüşmelerden ve örnek olaya ilişkin tutulmuş dokümanlardan elde edilen verinin tematik analizi yapılmıştır. Sosyal çalışma müdahale süreci tümdengelim yaklaşımıyla analiz çerçevesi olarak kullanılmıştır. Keşfedilmemiş örüntüleri bulmak için veri yeniden okunmuş (tümevarımsal analiz), öncelikle açık kodlama ile yeni temalar belirlenmiş ardından eksenli kodlama ile bu temalar arasındaki bağlantılar aranmıştır. Analizde MAXQDA 2020 programı kullanılmıştır. Araştırmanın sonuçları toplumsal cinsiyet eşitliğine duyarlı, hak temelli STÖ’lerin özellikle toplumsal cinsiyete dayalı şiddete maruz bırakılan mülteci kadınların güçlenmesinde ne kadar önemli olduğunu göstermektedir. STÖ’lerin Suriyeli kadınları güçlendirici bir sosyal çalışma müdahale süreci yürütmeye çalıştığı ancak makro düzeyde karşılaşılan sorunlar nedeniyle onların hayatlarında sosyal çalışma perspektifinin hedeflediği değişimi sağlayamadıkları görülmüştür. Sonuçlar sosyal devletin sorumluluklarını yerine getirmesi ve bölgesel kalkınmacı yaklaşımların hayata geçirilmesi gerektiğine işaret etmektedir. Bunun yanı sıra STÖ’lerin projeci anlayışı terk etmesi ve politik savunuculuk faaliyetlerini daha etkili bir şekilde yürütmesi gerektiği sonuçlarına ulaşılmıştır.
MERKEZİ YÖNETİMİN FİNANS VE UYGULAMA YETKİLERİNİN YERELE DEVRETMESİNE YÖNELİK BİR İNCELEME: OKUL GELİŞİM MODELİ (OGP)
Authors: AKYÜZ Ünal
Published: October 2023

Türk Eğitim Sistemi diğer kamusal alanlar gibi merkeziyetçi bir yönetim modeli ile yönetilmektedir. Bazı araştırmacılar tarafından eğitim sisteminin başarılı ya da başarısız olmasının nedenlerinden biri de aşırı merkeziyetçi olması gösterilmektedir. Avrupa Birliği (AB) finansmanlı Millî Eğitim Bakanlığı’nın Kapasitesinin Güçlendirilmesi Projesi (MEBGEP) ve Dünya Bankası (DB) raporlarında Türk Eğitim Sistemi’nde yetkilerin görece Bakanlıkta daha çok toplandığı konusunda görüş birliği içindedir. Türkiye’nin gelecekteki eğitim perspektifini, AB ülkelerindeki eğitim sistemlerini de karşılaştırarak üç farklı yönetim modeli geliştirilmiştir: “Mevcut Yapıda Etkinlik Sağlama (İyileştirme)”, “İl Odaklı Yönetim Modeli”, “Okul Odaklı Yönetim Modeli”. Türk Eğitim sisteminin en etkili ve karar verici organı olan Millî Eğitim Bakanlığı (MEB) bu modeller üzerinde uzun süre çalışmalar sonucunda iyileştirme denen mevcut MEB yapısında kısmi değişiklik yapmayı tercih etmiştir. Türk eğitim sistemi, mevcut altyapının modernizasyonu, öğretim programlarının güncellenmesi ve mesleki eğitimin AB standartlarına uyumlu hale getirilmesi gibi büyük sorunları çözmekle beraber, aşırı merkeziyetçilik nedeniyle ortaya çıkan sorunlar da giderek artan bir döngü içinde çözümsüzlüğe yol açmaktadır. Okul Gelişim Programı (OGP) bu problemlerden bir kısmına çözüm olması adına geliştirilen Dünya Bankası kaynaklı ancak özgün bir Millî Eğitim Bakanlığı projesidir. Eğitim sisteminin temeli olan okullardan bir kısmı ilk defa kendi ihtiyaçlarını belirlenmesi, buna yönelik çözümler geliştirmesi bunu da belli bir bütçeyle çözecekleri özgün bir alanın kendilerine sunulmasıdır. Bu yönüyle eğitim sisteminde il ve ilçelerin sorumlu yöneticileri okulların taleplerini daha fazla dikkate almış aralarında iş birliği istenen seviyeye ulaşmıştır. Okul Gelişim Programı, Türkiye’de okulların kendi ihtiyaçlarını, kendi bütçeleriyle çözebilme iradesi resmi kanallarla ve pilot bir projeyle denenmiş olması yönüyle de ilk olmuştur. Okul Gelişim Programı yıllardır eleştiri konusu olan Türk eğitim sisteminin okul temelli yapılandırılmasına yönelik en kapsamlı pilot projedir. Bu yönüyle çalışma, Okul Gelişim Programı’nın amacı, sureci, sonucu ve sürdürülebilirliği noktasında Türk eğitim sistemine ne gibi etkiler yaptığının anlaşılmasına olanak sağlayacaktır.
A STUDY ON DEMAND FOR ROMAN SCRIPT FOR KOKBOROK LANGUAGE BY THE INDIGENOUS TIPRA PEOPLE OF TRIPURA
Authors: Marconi Debbarma
Published: October 2023

This article delves into the complex issue of script selection for the Kokborok language in Tripura, where the imposition of the Bengali script against the desires of the indigenous people has ignited a profound struggle. We explore how this decision holds implications that extend far beyond language preservation, encompassing the preservation of indigenous identity, cultural rights, and resilience against cultural assimilation. It is argued that the movement advocating for the adoption of the Roman script for Kokborok exemplifies the unwavering determination of the indigenous Tipra people to safeguard their linguistic heritage. The Roman script, widely understood regionally and globally, not only transcends linguistic barriers but also fosters a sense of communal cohesion and empowerment. This movement is part of a broader narrative of resistance against the erosion of indigenous languages and cultures, resonating with similar struggles worldwide. The successful adoption of the Roman script not only validates cultural rights but also contributes to a more inclusive and compassionate world where linguistic diversity is celebrated and preserved for generations to come.
In memoriam del Profesor Justo García Sánchez, Catedrático de Derecho Romano de la Universidad de Oviedo (16 de Diciembre de 1946 – 18 de Agosto de 2023)
Authors: López-Rendo Rodríguez Carmen
Published: October 2023

In memoriam del profesor Justo García Sánchez (1946-2023)
Optimization and Processing of Cardiac and Islet Samples for RNA Sequencing
Authors:   , Bhatti Rohail , McGonigle Paul
Published: October 2023

Heart failure and diabetes are respectively the number one and seven leading causes of death in the US. In the heart, adult cardiomyocytes are terminally differentiated cells that are highly specialized to generate the necessary mechanical force and energetic potential needed to pump blood to the body. Similarly, pancreatic islets are highly specialized cells involved in glucose-mediated insulin and glucagon peptide responses in response to blood glucose levels. Due to the highly specific nature of these cell types, it is not surprising that gene expression patterns are uniquely fine-tuned to accommodate their biological role in physiological and pathological conditions. Recently, research has focused on deciphering metabolic pathways in these cells that are exclusive and altered in various disease states. A significant hurdle in utilizing tissue and/or primary myocytes and islets is the difficulty in handling and obtaining metabolically active and healthy specimens. Here, we aimed at optimizing and processing hearts and islets to obtain high-quality samples suitable for single cell/nuclei RNA sequencing studies. Through the implementation of rigorous quality control measures and the optimization of various parameters, a protocol has been developed for the heart and another for pancreatic islets that allows us to further assess cell-type specific signaling networks by single cell/nuclei RNA-sequencing strategies. The goal of employing these protocols is to explore novel tissue-specific pathways that undergo alterations due to genetic or pharmacological interventions. By unraveling the intricate molecular mechanisms underlying these conditions, new avenues for therapeutic interventions may be discovered, leading to improved patient outcomes and the potential to mitigate the devastating impact of heart failure and diabetes on public health.
Dynamic Inter-Node ILP Based Multi-Scratchpad Management for Deep Learning Accelerators
Authors:   , Jang Tajung , Das Anup
Published: October 2023

The landscape of deep learning compiler frameworks has evolved rapidly with the development of various tools, such as TVM, deeptools, TensorFlow, DLVM, nGraph, and Glow. These frameworks offer unique optimizations to address computation and data movement challenges in deep learning accelerators (DLAs). These approaches include graph or IR level optimizations related to intra node memory access optimizations, operator fusion, and various tiling techniques. Despite their unique approaches, these frameworks primarily concentrate on node level optimizations that focus on increasing the performance of executing a scheduled kernel operation in the graph and overlook the potential for inter-node data reuse optimizations within on-chip memory resources. OnSRAM, a scratchpad management framework build to work with deep learning compilers, addresses this gap by focusing on internode scratchpad management in DLAs. OnSRAM exploits the static graph representations of deep learning models by identifying data structures that can be pinned to on-chip memory based on their reuse rate and cost of transfer from main memory. OnSRAM has been implemented and evaluated on a single DLA that contains a monolithic scratchpad and is integrated as part of a custom deep learning compiler framework. In this work, we extend the capabilities of OnSRAM by introducing an optimal dynamic scratchpad allocation for static graph execution models using any number of scratchpads via Integer Linear Programming (ILP) to optimize an accurate cost model of data transfers. This enhancement allows for more wholistic control over on- chip memory resources compared to the heuristic approach OnSRAM takes, providing increased flexibility and adaptability to better accommodate diverse deep learning accelerators and memory access patterns. By optimizing inter-node data movement and storage across multiple scratchpads, our approach further reduces energy consumption and latency associated with inter-node communication.
Gemelo funcional para pruebas del software de sistemas de producción automatizados
Authors: Álvarez María Luz , Sarachaga Mª Isabel , Burgos Arantzazu , Iriondo Nagore
Published: October 2023

En el ámbito del paradigma de la Industria 4.0, el desarrollo del software de control de los nuevos sistemas de producción automatizados (aPS) se ha convertido en un proceso cada vez más complejo donde toman mayor importancia las pruebas del software. Este trabajo contribuye con una propuesta de desarrollo de gemelos funcionales, construidos a partir de componentes funcionales básicos reutilizables correspondientes a los módulos de control identificados en una unidad de trabajo de un aPS. Este gemelo funcional es una representación virtual de la funcionalidad del aPS y sirve como herramienta de pruebas para el software de control. Su construcción se realiza en el mismo entorno en el que se desarrolla el software de control siguiendo el estándar IEC 61131-3, sin requerir herramientas comerciales de desarrollo de plantas virtuales.
Detección de residuos urbanos mal ubicados mediante visión por ordenador e IA
Authors: Frutos Victoria , Pérez Borja , Campos Sergio , Barrera Alejandro , García Oscar , García Fernando , Al-Kaff Abdulla
Published: October 2023

La gestión de los residuos en las zonas urbanas es un aspecto esencial para la sostenibilidad y el mantenimiento del medio ambiente, así como de la salud pública. Además, el rápido crecimiento de las ciudades y de la población ha provocado un aumento de la generación de residuos que supone un reto global ya que en muchas ciudades del mundo la gestión de estos residuos se realiza de forma manual con las limitaciones típicas asociadas como el error humano, la fatiga ante tareas repetitivas o el coste económico. En este artículo se propone un sistema basado en visión por computador e inteligencia artificial con el fin de automatizar la detección de anomalías para la gestión de residuos en zonas urbanas y mejorar la eficacia en la etapa de recogida. También se expone el estudio de las pruebas realizadas en entornos reales así como un análisis de los resultados obtenidos y el proceso de mejora en las detecciones.
Amaranthus viridis improves relative anxiety behaviour and cognitive deficit in rotenone induced Parkinsonism in albino rats
Authors: Ohanme Eugene O. , Ofonakara Uzochukwu , Ofor Casimir  C. , Nwakelu Benjamin N. , Ramalan Mansur  A. , Eze Clementina N. , Nwafor Amauchechukwu V. , Anele Donatus O. , Akuodor Godwin C.
Published: October 2023

Background: Parkinson’s disease (PD) is typically characterised by motor shortfalls. However, non-motor symptoms like mood disorders (anxiety, depression) and impaired cognition are also associated features. Previous studies have demonstrated a neuroprotective effect a plant against a disease. Consequently, this current study was focused on assessing its efficacy in extenuating non-motor shortfalls such as anxiety-like behaviour and impaired cognition induced by rotenone.
Methods: PD was induced in rats by administering rotenone (10 mg/kg BW orally) for 28 days. The vehicle and the test drug were given orally daily for one hour prior to rotenone administration. The protective effect of methanol extract of A. viridis (500 mg/kg BW) was assessed through an array of tests; elevated plus maze test, Morris water maze test, and novel object recognition test. The rats were sacrificed on day 28th and neurobiochemical analyses of the hippocampus were performed using HPLC.
Results: The findings of this study showed that co-administration of A. viridis reversed the rotenone-induced anxiety-like behaviour and cognitive shortfalls to a significant extent (p<0.001).  It also restored the hippocampal neurotransmitters [(5-hydroxytryptamine (5-HT), 5-hydroxy indole acetic acid (5-HIAA), and dopamine (Da)] significantly (p<0.001).
Conclusions: Amaranthus viridis offered neuroprotective effects that ameliorate non-motor symptoms in PD. This could be a novel insight into the therapy of PD. This study provides scientific evidence that A. viridis attenuates non-motor symptoms like anxiety-like behaviour and cognitive deficits in Parkinsonism. This extract can be a potential candidate in herbal formulations as a neuroprotectant against PD.
Formulation and evaluation of a face serum containing fenugreek extract
Authors: Yeskar Harshal , Makde Prasad , Tiware Shital Anup , Shirbhate Trupti M. , Thakre Sagar V. , Darne Chetan S. , Sable Jyoti B. , Warghane Komal Khond , Baheti Jagdish R.
Published: October 2023

Background: Wrinkles on the face and aging of the skin are an undesirable effect of photodamage and ultraviolet radiation. Serum has a quick absorption and ability to penetrate deep layers of the skin, as well as a non-oily finish and a deep formula with a very high amount of active ingredients.
Methods: In this study, we have formulated and evaluated a face serum containing combination of aqueous extract of fenugreek seed and lemon oil.
Results: Facial serum was tested for its pH, physical appearance, viscosity, microbial testing, cyclic temperature test, etc. The results of the stability study show that there was no change in visual acuity, homogeneity.
Conclusions: Serum containing Fenugreek extract have been able to cure bacterial infections and inflammations of facial skin, and other signs also moistens the skin without any side effects making skin soft, smooth and supple.
Effectiveness of platelet transfusion in dengue fever: Rangpur community medical college and hospital experience at Rangpur, Bangladesh
Authors: Yusuf M. Ghulam , Rahman M. Ahashanur , Bhattacharjee Mriganko , Shaha Amaresh Chandra
Published: October 2023

Background: Dengue fever, caused by the dengue virus and transmitted by mosquitoes, is a global health concern, causing mild to severe illness. Severe cases lead to thrombocytopenia, a low platelet count that can cause bleeding. Platelet transfusion is debated as a treatment strategy; some studies support its use to prevent bleeding, while others raise concerns about side effects. The aim of the study is to see the effectiveness of platelet transfusion in dengue patients who has a very low platelet count.
Methods: This single-center study was conducted at The Department of Medicine, Rangpur Community Medical College and Hospital, Bangladesh. A total of 52 patients were enrolled and analyzed in this study from March to August 2023.
Results: Most cases are Dengue Fever (86.54%), followed by Dengue Hemorrhagic Fever Grade 1 (7.69%) and Dengue Shock Syndrome (5.77%). Bleeding occurred in 15.38% of enrollment. Common symptoms include fever (78.85%), headache (57.69%), cough (67.31%), and myalgia (55.77%). Health parameters include blood pressure (110/70 mm Hg), pulse rate (86.5±12.8 bpm), and temperature (100.5±2.8°F). Investigation findings show S. bilirubin (0.61 mg/dl), S. creatinine (0.94 mg/dl), RBS (120.5 mg/dl), HB% (13.78 g/dl), and PCV (39.75). Platelet counts varied in different conditions, with most responders to platelet transfusion (94.23%) showing no deaths but adverse outcomes related to transfusion reactions (5.77%).
Conclusions: The prevalence of dengue fever in Bangladesh necessitates a comprehensive understanding of effective treatment modalities. By examining the outcomes and implications of platelet transfusion in this context, the research seeks to shed light on its effectiveness, thereby informing evidence-based medical practices and improving patient care.
Respiratory symptom and disorder characteristic of farmer who exposed by pesticide
Authors: Candrawati Ni Wayan , Ngurah Rai Ida Bagus , Agung Krisdanti I Desak Putu , Andrika Putu , Kinanti Diah Permata , Sujana I Putu Surya , Widiasari Ni Putu Ayu , Sri Adiputri Kadek
Published: October 2023

Background: Pesticide is related to respiratory diseases; thus, personal protective equipment is very important as a preventive equipment while using pesticide. However, farmers in Indonesia still rarely use PPE when farming for reasons of inconvenience and availability problems.
Methods: This study was an analytic observational study with cross-sectional design. Sampling technique was consecutive sampling. Subject was 62 residents of Sukawana Village, Kintamani, Bangli who work as farmers and used pesticides.
Results: Dominant subject never experienced chronic respiratory symptom. The spirometry results showed mean of FVC (L) was 3.50 liters, FVC% was 93.31%, FEV1 (L) was 3.09, FEV1% was 97.64%, FEV1/FVC was 88.72, FEF 25-75% (L/s) was 4.07 liters/second, and FEF 25-75% was 106.95%. Age was significantly related to the occurrence of wheezing but not significantly related to another. Older people have significantly lower mean of FVC (L), FEV 1 (L), and FEF 25-75% (L/s) than younger. Smokers have significantly higher mean of FVC (L) and FEF 25-75% (L/s) than non-smokers.
Conclusions: The dominant subject never experienced chronic respiratory symptom with spirometry mean values within normal limits. Age was significantly related to the occurrence of wheezing. Older age has significantly lower mean of FVC (L), FEV 1(L), and FEF 25-75% (L/s).
The hyperthyroidism in gestational trophoblastic disease: a case report
Authors: Hokman Selvi , Wulandari Dewi Catur
Published: October 2023

Gestational trophoblastic disease, also referred to as GTD, is an extremely rare form of pregnancy-related complication that can arise. It covers a wide range of conditions, from choriocarcinoma to molar pregnancy. Patients who are diagnosed with gestational trophoblastic disease have an increased likelihood of developing hyperthyroidism. It is speculated that this occurs as a result of molecular mimicry that exists between human chorionic gonadotrophin (hCG) and thyroid-stimulating hormone (TSH), which results in cross-reactivity with the TSH receptor. This would explain why the two molecules would react similarly to each other. The gestational trophoblastic disease-induced thyroid storm is an extremely rare but potentially fatal complication that can arise during pregnancy. It is necessary to detect and treat this complication as soon as possible in order to prevent additional complications from occurring. Once the patient's hemodynamic status has been stabilized, the removal of the mole is the primary component of the definitive treatment that will be administered. In most cases, hyperthyroidism usually resolves once the gestational trophoblastic disease has been successfully treated and the hCG levels have been brought back to normal.
Idiopathic sequential bilateral profound sudden sensorineural hearing loss occurring 4 years after unilateral presentation
Authors: Patil Amol Anandrao , E. K. Suchina
Published: October 2023

Sudden sensorineural hearing loss is defined as hearing loss of 30db or more at least 3 consecutive audiometric frequencies occurring within 72 hours period or less. Unilateral presentation of sudden sensorineural hearing loss is common, however bilateral sequential presentation of this disease is very rare. Clinically we couldn’t anticipate the occurrence of sequential bilateral sudden sensorineural hearing loss at the first time. This bilateral sudden sensorineural hearing loss will affect the quality of life of patient. So, we report a case of 60 years old female patient with profound bilateral sudden sensorineural hearing loss with time interval of 4 years between involvement of both ears. Even though high dose steroid administered intravenously and intratympanic the patient’s hearing was not restored and eventually require hearing aids. The purpose of presenting this article is that sequential profound bilateral sensorineural hearing loss may present without any warning sign, response to treatment is very poor and the rarity of this condition.
Mandibular swing approach for high parapharyngeal space schwannoma
Authors: Ragavan Kumaran , Raja Premnath , Alagarsamy Balakrishnan , Manohar Amulya T.
Published: October 2023

Parapharyngeal space tumours are rare, comprising 0.5% of all head and neck neoplasms. Different surgical approaches to this space have been described based on various criteria. Here, we are presenting a case report of a 65-year-old woman with left vagal schwannoma splaying the left internal carotid artery and internal jugular vein superiorly and splaying the left internal carotid artery and external carotid artery inferiorly, with its upper edge about 0.7 cm caudal to skull base. Surgery by a combined trans-cervical and mandibular swing approach was adopted for this case. The tumour which was extending so close to the skull base was removed in toto with an intact capsule and the neurovascular structures like the carotids, internal jugular vein and the vagus were preserved through a trans-mandibular approach. Postoperatively patient had no neurovascular compromise. Histopathological examination revealed vagal schwannoma. Trans-mandibular approach may appear complex, but it offers excellent surgical field to keep the delicate surrounding structures intact, to reduce the risk of haemorrhagic and avoid neurological complications.
Cetyl alcohol, stearyl alcohol and colloidal oatmeal-based gentle skin cleanser in management of dry and sensitive skin: a cross-sectional study
Authors: Gupta Sumit , Shah Hemendra B. , Bhardwaj Praveen , Holani Aditya , Singh Charu , Yadav Sachin , Nair Rathish , Korukonda Krishnaprasad
Published: October 2023

Background: Effective skin cleansing is vital for maintaining skin health and appearance. An ideal skin cleaner retains moisture, removes oils, sweat, and dirt without causing irritation or dehydration. This study was designed to evaluate the efficacy, safety, tolerability and usage trends of a gentle skin cleanser containing cetyl alcohol, stearyl alcohol and colloidal oatmeal for individuals having dry and sensitive skin.
Methods: We conducted a retrospective review at 102 centres, focusing on individuals aged 18 to 65 years with atopic dermatitis and dry skin conditions who required the use of gentle skin cleanser. Total 568 cases were taken; 488 cases of dry and sensitive skin were further analysed over a 2-week study period.
Results: Gentle skin cleanser exhibited significant reduction (p<0.0001) in skin dryness, itchiness and irritation by 4.42±1.92 (63.38%), 4.03±2.71 (49.38%) and 4.44±2.07 (65.58%) respectively in participants with dry skin and by 4.25±1.48 (58.49%), 3.26±3.22 (18.02%) and 4.42±1.56 (63.23%) in participants with sensitive skin after its regular usage. Participants provided positive feedback and expressed overall satisfaction with the study product.
Conclusions: Skin cleanser was efficacious and well-tolerable in participants in providing moisturizing, soothing, exfoliating, and antioxidant effects making it a preferred primary choice for managing dry and sensitive skin. The cleanser effectively cleansed excess oil, dirt, dead cells, microorganisms, and sweat providing a gentle and mild experience, in daily skin care.
Aloe vera, wheat germ oil, tea tree extract and honey-based emollient cream in the management of atopic dermatitis: a post-hoc analysis
Authors: Ganjoo Anil , Shah Sunil , Godse Kiran V. , Porwal Shefali , Caplash Punam , Pereira Rickson , Nair Rathish , Korukonda Krishnaprasad
Published: October 2023

Background: Atopic dermatitis is a chronic skin condition characterized by dry, itchy and inflamed skin. This study evaluated the complementary benefits efficacy and tolerability of emollient c containing Aloe vera, Wheat germ oil, tea tree extract, and honey in patients with dry skin conditions.
Methods: Cross-sectional analysis for clinical cases with dry skin receiving moisturizing cream formulation was undertaken at 156 centres. 286 case records of atopic dermatitis receiving standard of care as cleansers, Topical corticosteroids, moisturizers were further analysed for improvement in skin dryness and itchiness.
Results: Regular use of Emollient formulation containing aloe vera, wheat germ oil, tea tree extract, honey was further analysed along with safety assessment over 8 weeks of observation period. The mean age of the study participants was 36.58 years. There was significant change in VAS score for dryness (p-value< 0.01), itch (p-value <0.01) with Patient Global Assessed rating as good (64.23%) for effectiveness and ease of application. Mild stinging, mild burning and irritation was experienced by 5 (1.75%) patients. 
Conclusions: The aloe vera, wheat germ oil, tea tree extract, honey enriched emollient formulation was efficacious and well tolerable in study participants in providing moisturizing, antimicrobial, and anti-inflammatory effects making it a preferred complementary therapy for managing atopic dermatitis following the short course therapy with TCS as a pertinent clinical strategy to avoid the atopic flares in such cases.
Methotrexate toxicity-an alarming bell!
Authors: Agarwal Pooja , Chaudhari Snehal V. , Baxi Kalgi , Neazee Sabha , Soneji Sohini , Shah Malhar J.
Published: October 2023

Since its introduction in 1951, methotrexate (MTX) has been widely used as the primary anti-psoriatic agent. However, unsupervised dosing by patients or concurrent use of excessive nonsteroidal anti-inflammatory drugs (NSAIDs) can lead to toxicity. Gastrointestinal symptoms are the most commonly observed manifestations, followed by cutaneous toxicity. In this retrospective study conducted at a tertiary care center in Gujarat, data from patients admitted for MTX toxicity between April 2017 and December 2019 were analyzed. A detailed history, including dosage, duration, signs and symptoms, investigations, treatment, and outcomes, was collected and evaluated. The study included 12 hospitalized patients (aged 35-70 years) with MTX toxicity. Among them, 10 patients had psoriasis, 1 had psoriatic arthritis, and 1 had rheumatoid arthritis with discoid lupus erythematosus. Eleven patients had taken daily oral MTX for one week along with painkillers, while one patient had taken an unknown amount without undergoing any investigations. Mucosal ulceration was observed in all cases, and skin necrosis was seen in 2 patients. Hematological investigations revealed myelosuppression in all patients, with altered renal function in 1 patient. Leucovorin (15 mg/ml) was administered to all patients, resulting in improvement for 10 patients, but 2 patients experienced persistent myelosuppression and succumbed to the toxicity. This study emphasizes the importance of pre-treatment investigations, proper monitoring, and strict avoidance of self-administration when administering MTX. Additionally, the co-administration of drugs such as NSAIDs should be judiciously managed. Folinic acid has shown usefulness in cases of MTX toxicity and overdose. In summary, this study underscores the significance of careful administration and monitoring of MTX, along with the avoidance of self-dosing. It highlights the need for judicious use of co-administered medications, and emphasizes the utility of folinic acid in managing MTX toxicity and overdose.
PARTIDO ACCIÓN NACIONAL Y LA DEMOCRACIA CRISTIANA
Authors: Alarcon Menchaca Laura
Published: October 2023

El Partido Acción Nacional (PAN) en México considerado un partido demócrata cristiano y que por varios decenios fue el partido opositor al grupo en el poder, se opuso a formar parte de la Organización Democracia Cristiana en América (OCDA) en los años sesenta del siglo XX debido, según señalaban sus dirigentes, a la imposibilidad legal para ello pero más aún, su fundador Manuel Gómez Morin, y su presidente Adolfo Christlieb Ibarrola se resistían a ello porque vislumbraban un intento por parte de los jóvenes de llevar al partido bajo otras directrices. El grupo promotor de jóvenes panistas que lo deseaban tendían a formar un movimiento que terminaría ajeno al partido y que no cumplía con los parámetros con que fue fundado. Los líderes de las juventudes panistas lucharon intensamente por lograr la pertenencia a la organización influenciados por demócratas cristianos como el líder venezolano Rafael Caldera. El rechazo por parte de los dirigentes generó fuertes tensiones entre ambos grupos que llevaron a una ruptura infranqueable y generaron una de las primeras grandes fracturas internas dentro del PAN. El abandono de las filas panistas de estos jóvenes como Alejandro Avilés, Hugo Gutiérrez Vega, Manuel Rodríguez Lapuente y Carlos Arriola entre otros, terminó siendo un parte aguas en la historia del partido y propició una reforma a la doctrina partidista de 1965 cuya autoría se debió a Efraín González Morfín y Christlieb Ibarrola. Con ello, el partido buscó dar una respuesta dinámica a los desafíos del momento que posteriormente recibió un fuerte rechazo por grupos que se oponían a los cambios.
Noticias del BID: Vol. 10, no. 6, agosto 1983
Authors:   Banco Interamericano de Desarrollo
Published: October 2023

Noticias del BID, publicación mensual que tiene por objetivo informar acerca de las actividades del Banco Interamericano de Desarrollo.
Estimacion de las especies monetarias en circulacion para una economía dolarizada: el caso de Ecuador
Authors: Cabezas Eduardo , Navarro Fabián , Pérez Danny , Torres Gina
Published: October 2023

La presente investigacion desarrolla una metodologa para la estimacion de las especies monetarias en circulacion (EMC) para el caso de una economa dolarizada como la ecuatoriana.Este enfoque se basa en el coeficiente de preferencia por la liquidez (CPL), el cual se define como la cantidad de dinero en circulacion (latente) sobre los depositos de ahorro y a la vista (observables). Este indicador latente es informado por: (i) las EMC actualmente calculadas por el Banco Central del Ecuador (BCE) bajo la metodologa de Vera (2007); (ii) la cantidad de dinero demandada de acuerdo con las funciones de dinero estructurales estimadas bajo modelos de cointegracion con quiebres estructurales; y (iii) la razon entre los retiros de efectivo y el saldo en depositos de ahorro en los bancos privados. El mecanismo de estimacion se realiza a traves de un modelo estado-espacio con metodos bayesianos, en donde el CPL es una variable latente que se descompone en ciclo y tendencia. Una vez obtenido el CPL como variable latente, se utilizan los depositos de ahorro y a la vista para obtener las EMC. Los resultados muestran que las EMC reportadas por el BCE son superiores a las obtenidas en esta investigacion. Dentro de los factores que podran explicar este resultado, se encuentran las salidas netas de efectivo por fronteras, cambios en la legislacion tributaria y en el Codigo Organico Monetario y Financiero anterior al ano 2020 que permita las inversiones domesticas por parte del BCE en ttulos de deuda del Gobierno Central.
Draft Dodger, Soldier’s Wife: Trans Feminine Lives, Civic Duty, and World War II
Authors: Oxford Juniper
Published: October 2023

This article examines trans feminine lived experiences in the United States during the Second World War amid persecution amplified by the Selective Training and Service Act of 1940, the May Act of 1941, and heightened visibility through local and national news publications. This article contends that there is a longer and more complicated linked history between trans feminine Americans and the U.S. military than has been acknowledged by both scholarship and public discourse. Federal statutes like the STSA and the May Act lent authority to the state and its auxiliaries beyond the singular municipal or county jurisdiction. These factors aided the legal persecution of innumerable Americans with perjury, draft evasion, ‘moral’, and fraud charges. Through case studies of the disparate circumstances surrounding the ‘discovery of sex’ of three individuals, Sadie Acosta, Lucy Hicks Anderson, and Georgia Black, this study illuminates the role of various actors involved in investigating and policing their ‘moral’ crimes and gender variance in the 1940s and 1950s. In the post-war years, the figure of the ‘ex-G.I.’ woman is seen through numerous well-publicized cases in the U.S. and the U.K., showing that trans feminine experiences of World War II could be found both at home and abroad.
Developing a Multichannel Bioreactor with a Collagen Scaffold, ECM, and Cryoprecipitate to Significantly Produce Platelets from Umbilical Cord Blood Stem Cells
Authors: Derakhty Gonbad Mohamad Hosein , Khoshfetrat Ali Baradar , Movassaghpour Ali Akbar , Sanaat Zohre , Charoudeh Hojjatollah Nozad
Published: October 2023

Background: Platelets play a key role in the treatment of thrombocytopenia. Nowadays, platelets (PLTs) are only obtained through blood donation. However, due to the limitations in their preparation and storage, they are produced in laboratories, especially through bioreactors that convert megakaryocytes from stem cells into large-scale injectable PLTs.
Materials and Methods: In this study, the CD34 cells isolated from cord blood were differentiated into megakaryocytes. A 6-chamber bioreactor with a two-layer collagen scaffold, several ECM factors, and human cryoprecipitate were used to simulate the structure of the bone marrow. After the addition of megakaryocytes to the scaffold, PLTs were produced due to the flow pressure and the interaction between the scaffold structure and the ECM factors.
Results: CD41 + cells were expanded 100 times as much as CD34 + cord blood stem cells. The mean PLT release from one megakaryocyte in the pure collagen scaffold was 17.42 PLTs. Once fibrin, fibronectin, hyaluronic acid, and cryoprecipitates were added to collagen, the mean PLT release was 21.4, 22.4, 23.9, and 27.37, respectively. With the simultaneous addition of three factors to collagen (CFFH) and then four factors (CFFHC), the number of PLTs reached 30.52 and then 34.
Conclusion: Functional PLTs can be produced on a large scale with a multi-chamber bioreactor using a combination of ECM and cryoprecipitate with collagen scaffolding.
Arsenic levels in rice brands sold in Kampala: an experimental study to show the modifying effect of boiling, soaking and washing
Authors: Sembajwe Lawrence Fred. , Nfambi Joshua , Lugaajju Allan , Namaganda Agnes , Acen Ester Lillian , Kalyesubula Robert
Published: October 2023

Arsenic is an important environmental pollutant with potential cancer-causing effects. It contributes to acute and chronic toxicity depending on the doses or duration of exposure. In this study, we estimated the concentration of total arsenic in different rice brands sold in Uganda, where rice is a staple food. We conducted an experimental study. Different rice brands were obtained from supermarkets and grocery shops, and assessed for arsenic using atomic absorption spectrometry. The concentrations of arsenic in rice were estimated after boiling, washing, or overnight soaking in plenty of water to see if these methods reduce arsenic levels efficiently in food. The concentrations of arsenic in the different rice brands were compared using an unpaired t-test after setting a p-value of ≤0.05 as significant. The G-rice brand had the lowest arsenic levels of 1.4±0.0002 ppm and the C-rice brand had the highest levels of 2.4±0.004 ppm. The tap water used to boil, soak and wash the rice brands had much higher arsenic levels of 3.5±0.000003 ppm, leading to increased retention of the heavy metal in the rice. Rice brands sold in Kampala city seem to have higher than acceptable arsenic levels. Increased vigilance in terms of routine monitoring for the levels of arsenic in rice and water used during food preparation by the Ugandan food or water safety regulatory authorities is highly recommended.
Effect of extracts of Citrus sinensis (Rutaceae) and Trichilia havanensis (Meliaceae) in mortality and repellence of Tetranychus urticae (Acari: Tetranychidae)
Authors: Rivera Hernández Mitchel , Luna Guevara Juan José , Aragón García Agustín , Pérez Torres Betzabeth Cecilia , López Olguin Jesús F.
Published: October 2023

This work aimed to evaluate the effect of the plant extract from the peel of Citrus sinensis and the seeds of Trichilia havanensis on mortality and repellency in different biological states of Tetranychus urticae under laboratory conditions. Solutions of the extracts at 500, 1000 and 1500 mg.L-1 were applied to a known number of eggs, larvae, and female adults of T. urticae in foliar discs of bean (Phaseolus vulgaris L.). The data analysis of mortality percentage and the repellence (Kruskal-Wallis test and comparison of medians, (α=0.05) showed that the extract of T. havanensis presented the highest percentage of mortality in eggs with 45.0 % at 1500 mg.L-1, and the extract of C. sinensis presented the highest mortality in larvae with 40.0 % at 1000 mgL-1, and adults with a 50.0 % at 1500 mg.L-1. The highest percentage of repellency was the extract of C. sinensis at 1500 mg.L-1, with 30 % in larvae and 60.0 % in adults. The results indicate that the extracts have the potential to develop effective products for managing T. urticae.
Jezikovna politika Republike Slovenije in oglaševanje
Authors: Klajnšek Aljanka
Published: October 2023

Namen prispevka je prikazati jezikovno politiko Republike Slovenije v širšem okviru sistema javnofinančnega načrtovanja, ki je povezan z ekonomskim upravljanjem EU in usmerjen v trajnostni razvoj. V tem okviru prispevek obravnava problematiko javne rabe slovenščine v oglaševanju. Osredotoča se na konflikt med prizadevanji po ohranitvi slovenskega jezika v oglaševanju in pravili enotnega trga EU, ki zaradi varovanja svoboščin na enotnem trgu načeloma zahtevajo, da jezik v oglaševanju v Republiki Sloveniji ni nujno slovenščina. Prispevek daje predloge izboljšav v povezavi z ugotovljenimi pomanjkljivostmi strateško-razvojnega načrtovanja v Republiki Sloveniji in spremembami v razmerjih med posameznimi vidiki razvoja v okviru EU.
Neizogibni posrednik – položaj družbe Google na trgu digitalnega oglaševanja EU z vidika konkurenčnega prava EU
Authors: Jovanović Nikola
Published: October 2023

Namen prispevka je celovit pregled tehnološke strukture na trgu digitalnega oglaševanja, ključnih udeležencev na tem področju ter pomembnih posredniških orodij. Prispevek poudarja vlogo digitalnega oglaševanja za sodobno gospodarstvo in obravnava ključne tehnološke spremembe, ki so zaznamovale to področje. Z razvojem digitalnih tehnologij je oglaševanje prešlo iz tradicionalnega modela založnikov tiska in oglaševalcev v avtomatiziran, programatični model. Poseben poudarek je namenjen analizi položaja družbe Google v vrednostni verigi digitalnega oglaševanja ter morebitnim konkurenčnopravnim izzivom, povezanim z njegovim prevladujočim položajem. V prispevku so obravnavane tudi pomembne tehnologije, ki so se razvile v povezavi z digitalnim oglaševanjem, vključno s programatičnim zakupom oglasnega prostora in uporabo podatkovnega ciljanja za optimizacijo kampanj.
Use of intraoperative navigation in endoscopic endonasal surgery for paranasal mucocele
Authors:   Burdenko National Medical Research Center for Neurosurgery, Moscow, 125047, Russia, Doronina V. A. , Shelesko E. V. ,   Burdenko National Medical Research Center for Neurosurgery, Moscow, 125047, Russia, Batalov A. I. ,   Burdenko National Medical Research Center for Neurosurgery, Moscow, 125047, Russia, Strunina Yu. V. ,   Burdenko National Medical Research Center for Neurosurgery, Moscow, 125047, Russia, Chernikova N. A. ,   Burdenko National Medical Research Center for Neurosurgery, Moscow, 125047, Russia, Zinkevich D. N. ,   Burdenko National Medical Research Center for Neurosurgery, Moscow, 125047, Russia, Pronin I. N. ,   Burdenko National Medical Research Center for Neurosurgery, Moscow, 125047, Russia
Published: October 2023

Objective. Evaluation of the effectiveness, safety, and benefit of the use of electromagnetic computer navigation in endoscopic endonasal surgery of paranasal mucocele. Materials and methods. At the Burdenko National Medical Research Center, from 2019 to 2022, 30 endoscopic endonasal removal of paranasal mucocele were performed: 10 operations were performed under CT-guided navigation, 12 with CT-MRI navigation, and 8 without navigation. The clinical findings of the disease, the history of life of patients, the data of endoscopic examination of the nasal cavity, olfactometry, intraoperative parameters, recurrence rate of the mucocele were analyzed. Results. Localization of the mucocele in the frontal sinus was significantly more common in the groups using navigation (p = 0.044). According to olfactometry before surgery, anosmia on the side of the pathology was more often detected in patients in groups using navigation (p = 0.005). According to endoscopy before surgery, scarring in the nasal cavity was found only in groups using navigation. There were no intraoperative complications in the three groups. The average intraoperative blood loss in the three groups did not differ significantly. The duration of the operation was slightly longer in the groups using navigation. The median navigation setup time in the CT navigation group was 8.5 [7.3; 9.8] min, in the CT-MRI navigation group it was 7.5 [7.0; 8.3] min. The median error in each group was 0 mm. According to the operating surgeon, computer navigation was necessary and the most beneficial in 100% of cases. The median long-term follow-up was 746 [478.3; 1133.0] days in the non-navigation group, 673 [176.0; 791.0] days in the CT-navigation group, and 274 [195.5; 371.0] days in the CT-MRI navigation group. Conclusion. The use of intraoperative navigation is justified in endoscopic debridement of mucocele with destruction of the walls of the orbit and the base of the skull, with scarring in the nasal cavity. The use of CT-MRI navigation is useful in a case of scarring in the nasal cavity and deformation of the orbit walls in the case of a fronto-orbital mucocele as well as while removing a sinonasal neoplasm bordering on the mucocele.