bluuebunny/crossref_metadata_2025 huggingface dataset:
Stereoselective Two-Carbon Ring Expansion of Allylic Amines via Electronic Control of Palladium-Promoted Equilibria
Authors: Knowles Jonathan , Mikan Charles , Matthews Aidan , Harris Daniel , McIvor Charlotte , Waddell Paul , Sims Mark
Published: April 2023

Despite their potential value within drug discovery, general methodologies enabling the two-carbon homologation of pyrrolidine and piperidine systems have yet to be developed. Herein we report that palladium-catalysed allylic amine rearrangements enable efficient two-carbon ring expansion of 2-vinyl pyrrolidine and piperidines to their azepane and azocane counterparts. Conditions are mild, tolerant of a range of functional groups and the process can occur with a high degree of enantio-retention. The products formed undergo a range of orthogonal transformations, making them ideal scaffolds for the creation of compound libraries.
Structural and Electrochemical Evolution of Alloy Interfacial Layers in Anode-Free Solid-State Batteries
Authors: Sandoval Stephanie , Lewis John , Vishnugopi Bairav , Nelson Douglas , Schneider Matthew , Cortes Francisco , Matthews Christopher , Watt John , Tian Mengkun , Mukherjee Partha , McDowell Matthew
Published: April 2023

“Anode-free” solid-state batteries feature high energy density since there is no anode active material upon assembly. While beneficial effects of interfacial layers have previously been demonstrated, the mechanisms through which they influence lithium plating/stripping are unclear. Here, we reveal the evolution of 100-nm silver and gold interfacial layers during anode-free lithium plating/stripping using electrochemical methods, electron microscopy, and modeling. The alloy layers significantly improve Coulombic efficiency and resistance to short circuiting, even though the alloys form solute regions or particulates that detach from the current collector as lithium grows. In-situ electrochemical impedance spectroscopy shows that the alloy layers return to the interface and mitigate contact loss at the end of stripping, avoiding a critical vulnerability of anode-free cells. The enhanced contact retention is driven by increased Li uniformity that promotes spatially even stripping, as well as local alloy delithiation in response to current concentrations to homogenize current and diminish voiding.
Host Dynamics under General-Purpose Force Fields
Authors: Wang Xiaohui , Huai Zhe , Sun Zhaoxi
Published: April 2023

Macrocyclic hosts as prototypical receptors to gaseous and drug-like guests are crucial components in pharmaceutical research. The external guests are often coordinated at the center of these macromolecular containers. The formation of host-guest coordination is accompanied by the broken of host-water and host-ion interactions and sometimes also involves some kinds of conformational rearrangements of the host itself. A balanced description of various components of interacting terms is indispensable. However, up to now, the modelling community still lacks a general yet detailed understanding of commonly employed general-purpose force fields and the host dynamics produced by these popular selections. To fill this critical gap, we in this paper profile energetics and dynamics of four types of popular macrocycles, including cucurbiturils, pillararenes, cyclodextrins, and octa acids. The presented investigations of force-field definitions, refitting and evaluations are unprecedently detailed. Based on the valuable observations and insightful explanations, we finally summarize some general guidelines on force-field parametrization and selection in host-guest modelling.
Nonenzymatic anaerobic ammonium oxidation through a hydrazine intermediate
Authors: He Daoping , Adachi Kiyohiro , Hashizume Daisuke , nakamura ryuhei
Published: April 2023

Anaerobic ammonium oxidation (anammox) − the biological process that activates ammonium with nitrite − is responsible for a significant fraction of N2 production in marine environments. Despite decades of biochemical research, however, no synthetic models capable of anammox have been identified. Here, we report that a copper sulfide mineral replicates the entire biological anammox pathway catalyzed by three metalloenzymes. A copper-nitrosonium (Cu+−NO+) complex formed by nitrite reduction was identified as the oxidant for ammonium oxidation, leading to heterolytic N−N bond formation from nitrite and ammonium. Similar to the biological process, N2 production was mediated by the highly reactive intermediate hydrazine, one of the most potent reductants in nature. Another pathway involving N−N bond heterocoupling for the formation of hybrid N2O, a potent greenhouse gas with a unique isotope composition, was also identified. Our study represents the first nonenzymatic anammox reaction that interconnects six redox states in the abiotic nitrogen cycle.
Coordinatively Unsaturated Metallates of Cobalt(II), Nickel(II), and Zinc(II) Gated by a Rigid and Narrow Void
Authors: Hastings Christopher , Huffman Lucy , Tiwari Chandan , Galindo Betancourth Jolaine , Brennessel William , Barnett Brandon
Published: April 2023

Both natural enzymatic systems and synthetic porous material catalysts utilize well-defined and uniform channels to dictate reaction selectivities on the basis of size or shape. Mimicry of this design element in homogeneous systems is generally difficult owing to the flexibility inherent to most small molecular species. Herein, we report the synthesis of a tripodal ligand scaffold which orients a narrow and rigid cavity atop accessible metal coordination space. The permanent void is formed through a macrocyclization reaction whereby the 3,5-dihydroxyphenyl arms are covalently linked through methylene bridges. Deprotonative metallation leads to anionic and coordinatively unsaturated complexes of divalent cobalt, nickel, and zinc. An analogous series of trigonal monopyramidal complexes bearing a non-macrocyclized variant of the tripodal ligand are also reported. Physical characterization of the coordination complexes has been carried out using multiple spectroscopic techniques (NMR, EPR, UV-Vis), cyclic voltammetry, and X-ray diffraction. Complexes of the macrocyclized [LOCH2O]3– ligand retain a rigid cavity upon metallation, with this cavity gating entrance to the open axial coordination site. Through a combination of spectroscopic and computational studies, it is shown that acetonitrile entry into the void is sterically precluded, disrupting anticipated coordination at the intracavity site.
National Medical Research Center for Pulmonology: experience of the first year of work and development prospects: A review
Authors: Avdeev Sergey N. , Voznesenskiy Nikolay A. , Merzhoeva Zamira M. , Nikitina Lidia Yu. , Berikkhanov Zelimkhan G.-M.
Published: April 2023

The article highlights the main activities of the National Medical Research Center for Pulmonology of the Sechenov University. The main results of clinical, analytical and educational activities are outlined. The prospects for the development of the pulmonological service of the Russian Federation, current problems and their solutions are determined.
The Frequency of Rotavirus Infection among Children under the age 5 years in Erbil Province, Kurdistan Region, Iraq, a hospital based study
Authors:   College of Health Sciences, Hawler Medical University, Erbil, Iraq, Dawod Nasih Lana , Sabir Ali Katan
Published: April 2023

Background:Globally, rotavirus infection, which results in gastroenteritis, is one of the major health problems. Millions of children are infected with the disease. Viral gastroenteritis must be recognized early because it causes wasteful antibiotic use and hospitalizations for kids. Objective: To investigate the frequency of rotavirus in stool samples from children with acute gastroenteritis. Patients and Methods: Cross-sectional study consisting of one hundred fifty-three fresh stool samples collected from children less than 5 years were admitted to Raparin pediatric hospital in Erbil city between November 2021 and April 2022. Rotavirus antigens were detected by Rapid test. Results: Rotavirus antigen was detected at an estimated rate of 61 (40%) in 153 studied cases. The frequency of rotavirus among male and female patients was 44.1% and 33.3% respectively. According to age of infants, rotavirus was detected most frequency in eight months of age. As well as the frequency rate among rural and urban patients was 40% and 39.8% respectively. Rotavirus was detected among vaccinated and non-vaccinated patients by the frequency 26.3% and 54.8% respectively. The highest frequency rate was detected in January 46.4%. Detection of rotavirus by age group was and vaccinations were significant in this study by p-value of 0.001. Conclusion: The most common cause of acute gastroenteritis in children in our area is rotavirus . Rotavirus infection is most frequently occurring during the winter season and among children between 6 months to 24 months. Conclusion: In this study we found cigarette smoking was more commonly practiced than water pipe .Nicotinic stomatitis is more prevalent in cigarette smoking and its incidence increased with duration and frequency of the habit.
The cytochromebcarboxyl terminal region is necessary for mitochondrial complex III assembly
Authors: Flores-Mireles Daniel , Camacho-Villasana Yolanda , Lutikurti Madhurya , García-Guerrero Aldo E , Lozano-Rosas Guadalupe , Chagoya Victoria , Gutiérrez-Cirlos Emma Berta , Brandt Ulrich , Cabrera-Orefice Alfredo , Pérez-Martínez Xochitl
Published: April 2023

Mitochondrialbc1complex from yeast has 10 subunits, but only cytochromeb(Cytb) subunit is encoded in the mitochondrial genome. Cytbhas eight transmembrane helices containing two hemesbfor electron transfer. Cbp3 and Cbp6 assist Cytbsynthesis, and together with Cbp4 induce Cytbhemylation. Subunits Qcr7/Qcr8 participate in the first steps of assembly, and lack of Qcr7 reduces Cytbsynthesis through an assembly-feedback mechanism involving Cbp3/Cbp6. Because Qcr7 resides near the Cytbcarboxyl region, we wondered whether this region is important for Cytbsynthesis/assembly. Although deletion of the CytbC-region did not abrogate Cytbsynthesis, the assembly-feedback regulation was lost, so Cytbsynthesis was normal even if Qcr7 was missing. Mutants lacking the CytbC-terminus were non-respiratory because of the absence of fully assembledbc1complex. By performing complexome profiling, we showed the existence of aberrant early-stage subassemblies in the mutant. In this work, we demonstrate that the C-terminal region of Cytbis critical for regulation of Cytbsynthesis andbc1complex assembly.
Application of PCA Numalgorithm in Remote Sensing Image Processing
Authors: Dai Hong
Published: April 2023

A numerical algorithm of principal component analysis (PCA) is proposed and its application in remote sensing image processing is introduced:(1) Multispectral image compression; (2) Multi-spectral image noise cancellation; (3) Information fusion of multi-spectral images and spot panchromatic images. The software experiments verify and evaluate the effectiveness and accuracy of the proposed algorithm.
Peculiarities of pharmacotherapy of chronic heart failure with retained left ventricular efficiency and associated atrial fibrilation depending on the method of heart rhythm control
Authors: Zolotarova Tetiana , Bilchenko Oleksandr , Volkov Dmytro , Pasyura Igor , Prylutska Kateryna
Published: April 2023

Introduction. Only small studies in selected centers have examined the effect of rhythm control strategy, including catheter ablation, on major cardiovascular events, mortality in patients with long-term atrial fibrillation and concomitant chronic heart failure with preserved left ventricular ejection fraction and features of pharmacotherapy. The aim. To study the peculiarities of pharmacotherapy in patients with heart failure with preserved left ventricular ejection fraction and concomitant atrial fibrillation over a long period of observation, depending on the implementation of a rhythm control strategy: radiofrequency ablation or pharmacotherapy and their impact on endpoints. Materials and Methods. The study included 194 patients with a mean age of 59.3 ± 8.5 years with atrial fibrillation and concomitant heart failure with preserved left ventricular ejection fraction I–III of the NYHA functional class. Patients were divided into 2 groups: 136 patients who underwent radiofrequency ablation, and 58 patients in the control group who did not undergo intervention and continued antiarrhythmic pharmacotherapy. The patients were compared according to the main clinical and demographic indicators. An assessment was made of the characteristics of pharmacotherapy and different stages of observation by group and its impact on endpoints. Results. In the control group, the use of antiarrhythmic drugs other than amiodarone and oral anticoagulants at the baseline of the study was associated with the primary endpoint. The chance of its occurrence was 3.9 times higher among patients taking other antiarrhythmic drugs (odds ratio–3.949, 95 % confidence interval 1.198–13.013) and 1.8 times lower among patients taking anticoagulants (odds ratio - 0.556, 95 % confidence interval 0.399–0.965). In the ablation group, the chance of a primary endpoint event occurring was 3.1 times higher among patients taking diuretics at 2-year follow-up (odds ratio –3.130, 95 % confidence interval 1.111–8.824), and beta-blockers were associated with 3.4 times lower chance of these events (odds ratio – 0.296, 95 % confidence interval 0.128–0.688). In the ablation group, there was a statistically significant decrease in the percentage of patients requiring diuretics 2 years after inclusion in the study compared with the 3-month stage (p < 0.001) and the inclusion stage (p < 0.001). Conclusions. Long-term use of beta-blockers after intervention is associated with a reduced risk of primary endpoint events in the ablation group. Taking diuretics, beta-adrenergic receptors, and renin-angiotensin-aldosterone system inhibitors during the first 3 months after the intervention reduces the risk of atrial fibrillation recurrence in the long-term follow-up period in the ablation group.
Modern methods of surgical hearing prosthesis
Authors: Panchenko Tetyana
Published: April 2023

Resume. In recent years, the number of patients with hearing impairments around the world is constantly increasing. The WHO estimates that the unresolved problem of hearing loss costs the world 980 billion US dollars annually. Currently, the number of children and adults with sensorineural hearing loss has increased significantly. The aim of the work is to investigate the consequences of hearing loss in humans, and to describe current surgical methods of solving the problem based on scientific analysis of modern literature. Materials and methods. A comprehensive search of relevant literature sources was conducted in December 2021 using such electronic databases as RubMed, EMBASE, MEDLINE, U.S. National Library of Medicine Clinical Trials, Research Gate and Cocharane Library. Results. Despite the high-tech diagnostic capabilities of modern medicine, the study of etiology, prevention and correction of various hearing impairments in people of all ages take a paramount role in the modern medical community. Hearing aids are not able to transmit the full range of the sound palette to a person who is hard of hearing. In the analysis of the studied literature, modern surgical methods of correction of hearing disorders are cochlear implantation, bone-conducting system of sound conduction and brain-stem implantation. Each method has advantages, indications and features of rehabilitation. Restoration of hearing for a deaf child / adult is the result of the teamwork of psychologists, audiologists, otosurgeons/neurosurgeons, anesthesiologists, engineers and rehabilitation specialists. Conclusion. Hearing plays one of the most important roles in the formation and development of any society, transfer of accumulated knowledge from generation to generation through the formation of speech and communication skills. For timely detection of hearing impairment, on-time correction and rehabilitation measures, pediatricians and family doctors must know how to correct hearing impairment, taking into account modern medical and digital technologies.
La Feria Lúdico-Pedagógica y su impacto curricular: transformando la práctica docente
Authors: Jaimes Castañeda Amparo , Aragon Goyes Maritza , Martinez Rodriguez Nancy Johanna , Rincon Jaimes Eduard Anderson , Gutierrez Ojeda Patricia , Barria Cornejo Daniel Ignacio , Margery Bertoglia Enrique Juan , Garrido Romero Victor Andres
Published: April 2023

El libro La Feria Lúdico-Pedagógica y su impacto curricular: transformando la práctica docente tiene un gran valor, por tres razones principales: primero, ubica a la expresión lúdica en el centro de la experiencia educativa; segundo, comunica la idea de una docencia de avanzada, llevada a cabo por genuinos profesionales de la práctica y, en tercer lugar, nos remite a una sistematización de la experiencia, alrededor de la figura de la Feria Lúdico-Pedagógica, “como espacio de reflexión curricular” y “lugar del primer encuentro con la práctica docente”. Por lo anterior, hablamos de un libro necesario, pues indaga sobre la práctica docente, pero lo hace combinando un sólido soporte teórico con los saberes situados que resultan de la praxis innovadora.
A novel approach for E-Government services with artificial intelligence using CNN
Authors: B. Raja Srinivasa Reddy , Konda Sreenu , Miriyala Raghava Naidu
Published: April 2023

Artificial Intelligence (AI) is a domain that works on various complex applications, such as E-government services. In order to provide government services to the people, an online AI-based Deep Learning (DL) model has been developed to check the availability of government schemes. However, several E-government services are not available to the citizens based on their usage. Many challenges have been identified while using E-Government services. This paper introduces the DL model, Convolutional Neural Networks (CNN), to solve the issues in E-Government services. The system focuses on maintaining E-government data resources, and CNN is primarily used to automate E-Government services. Finally, CNN has developed an innovative E-Government environment to support the design, development, and implementation of applications.
Deep Convolutional Neural Network with a Stochastic Gradient Descent Optimizer (PDCNN-SGD) model for telugu character recognition
Authors: Josyula Siva Phaniram , M. Babu Reddy
Published: April 2023

Telugu Character Recognition (TCR) has received significant attention because of the drastic increase in technological advancements such as multimedia, smartphones and iPods, and paper documents. Offline character recognition is the process of identifying Telugu characters from the scanned image or document whereas online character recognition enables to recognition of characters by the machine while the user writes. Several researchers have attempted to design online TCR models by the use of distinct classification models and feature extraction approaches. It is still necessary to construct automated and intelligent online TCR models, even if many studies have focused on offline TCR models. The Telugu character dataset construction and validation using an Inception and ResNet-based model are presented. The collection of 645 letters in the dataset includes 18 Achus, 38 Hallus, 35 Othulu, 34*16 Guninthamulu and 10 Ankelu. The proposed technique aims to efficiently recognize and identify distinctive Telugu characters online. This model's main preprocessing steps to achieve its goals include normalization, smoothing, and interpolation. Improved recognition performance can be attained by using Stochastic Gradient Descent (SGD) to optimize the model's hyperparameters.
The enzymal substantiation of lymphotropic antibacterial therapy in an acute pancreatitis
Authors: Duzhyi I. D. , Kononenko M. G. , Sytnik O. L. , Shimko V. V. , Kravets O. V. , Medvedieva I. M.
Published: April 2023

Objective. To study the impact of antibacterial therapy on level of proteolytic enzymes on example of the neutrophils elastase, and clinical course of an acute pancreatitis.

Materials and methods. There were investigated two groups of patients: in the main group (n=83) antibiotics were introduced by lymphotropic method, while in a control group (n=85) – in accordance to standard method. The content of the neutrophils elastase was determined in admittance day after 5 days of treatment.

Results. In admittance to hospital the enzyme level in patients of both groups did not differ. After 5 days of antibacterial therapy the neutrophils elastase quantity have been reduced more after conduction of lymphotropic therapy than after the standard one. Reduction of level of the neutrophil elastase «deflected» have promoted the reduction of the pancreonecrosis infectioning, leading to reduction in the operative interventions quantity performed in the main group of patients (lymphotropic antibacterial therapy) in 2.1 times as well as their reconvalescence.

Conclusion. Positive impact of lymphotropic antibacterial therapy towards «deflection» of proteolytic enzymes in the blood and on the acute pancreatitis course accordingly shows the reasons to recommend its application in this disease as an alternative to standard method.
Assessment of Sleep Disorders in Children with Transfusion-Dependent Hemoglobinopathies
Authors: Ali Ahmed Masoud , Mohamed Ahmad Darwish , Elbilsha Mona Ahmed
Published: April 2023

Purpose: The aim of this study was to compare sleep problems between children with transfusion-dependent hemoglobinopathies and healthy controls.Methods: This study was a case-control survey of children with transfusion-dependent hemoglobinopathies. The sample consisted of 175 children in the patient group and 175 healthy children in the control group, with an age range of 8 to 18 years. Subjects were recruited from the Children’s Hospital of Mansoura University between February and July 2022. Children with transfusion-dependent hemoglobinopathies received consultations at the Department of Pediatric Hematology. The Children’s Sleep Habits Questionnaire (CSHQ) was used to evaluate sleep problems in both groups.Results: The mean age of the patient group was 11.22±2.39 years, and 52.57% (n=92) were girls. The control group had a mean age of 11.30±2.16 years, and 50.86% (n=89) were boys. The overall score (P=0.007) and the night waking (P=0.013), sleep duration (P=0.009), and sleep-disordered breathing (P=0.029) subscores were all substantially and statistically significantly higher in children with transfusion-dependent hemoglobinopathies than in healthy children.Conclusion: As children with transfusion-dependent hemoglobinopathies have more sleep problems than healthy children, more detailed studies are needed.
A Study on the Effect of Political Efficacy of Youth generation on Social Trust and Government Trust: Focusing on the Mediating Effect of Social Fairness
Authors:   The Korea Association Of Governance Studies, Hong Sangwoo , Kim Donguk , Kim Hwayeon
Published: April 2023

The younger generation has become the focus of various policies proposed by political circles, including those discussed during South Korea’s recent 20th presidential election. Despite the prioritization of “fairness,” which is considered the most important value by the younger generation, and efforts to secure their votes, political circles have failed to gain their sympathy. Numerous surveys have shown that the younger generation perceives society as unfair, which leads to a decline in trust in the government and society.
This study attempted to analyze the relationship between the political efficacy of the younger generation, social fairness, and trust in the government and society. To accomplish this, descriptive statistical analysis, exploratory factor analysis, reliability analysis, and covariance structure analysis were conducted. The results indicate that the internal and external political efficacy of young people has a positive effect on government trust and social trust through social fairness. Thus, enhancing the political efficacy and social fairness of the younger generation is necessary to increase their trust in the government and society. The study concludes by presenting theoretical and political implications.
The Policy Effect of the Urban Regeneration New Deal projects in Local Industrial Cities: Focusing on the Industrial Crisis Response Special Area
Authors:   The Korea Association Of Governance Studies, Ryu Kyung Won , Shin Eun Jin , Park Hyung Jun
Published: April 2023

This study analyzed the policy effect of the urban regeneration New Deal project on the industrial structure of local industrial cities. The Urban Regeneration New Deal Project is an urban regeneration policy that activates urban declining areas in terms of society, economy, and physics. Therefore, this study analyzes the impact of the urban regeneration New Deal project on the industrial diversity and industrial specialization of local industrial cities. To this end, the research subjects were composed of regions selected as special industrial response areas among local industrial cities, and the analysis unit was composed from 2015 to 2020. In addition, it was intended to increase research reliability through the propensity score matching, and difference-in-difference models were conducted to derive policy effects between regions where the project was put and regions where it was not. As a result of the analysis, it was confirmed that the urban regeneration New Deal project did not affect industrial diversification in local industrial cities and negatively affected industrial specialization in specific sectors. Based on the analysis results, this study suggests planning in connection with the industrial structure of the region and expanding the participation of the private sector as ways to improve urban regeneration policies.
W kleszczach transnarodowości. 1983
Authors: Katner Mateusz
Published: April 2023

Netflix, which is the worldwide American streaming platform available globally, produces numerous serious not only in the United State but outside the country as well. Those specific projects have wide audience all around the world, and, what needs to be emphasized, are particularly appealing to the users in each region respectively. However, the 1983, first Polish series by Netflix Original, has met quite cold reception especially in the country of its production. In this paper author states that this kind of the series’ perception stems from its transnational formula which in this case results in disappointing effects in several dimensions: preproduction, implementation, and further publicity.
Land, Ceramics and Seigniorial Rents in the Late Middle Ages: the Manor of Manises in the Kingdom of Valencia, c. 1400-1575
Authors: Furió Antoni , Almenar Fernández Luis
Published: April 2023

During the last two centuries of the Late Middle Ages lords experienced a substantial fall in rents, which was exacerbated in the case of Valencia due to the small size of local manors. The will to keep their levels of incomes brought lords to demand higher burdens from their vassals, especially Muslims, while some nobles, in addition, invested in the productive structures of their estates. Such was the case in the manor of Manises, where since the early fourteenth century an important ceramic manufacturing had developed, which attracted the interest of buyers from all over Europe. This production took place in a medium-sized manorial village, inhabited by a mixed population of Muslims and Christians, which maintained its engagement with agricultural labour. The aim of this article is to analyse the rents of the manor of Manises through two unpublished and exceptional manorial sources, namely, two registries datable from the early fifteenth century and the early sixteenth century respectively, although the latter continued to be used until the end of the century. These allow the exploration of the structure of seigniorial revenues, showing the incidence that agrarian rents and those coming from ceramic production represented over the total. The tendency followed by the manorial rents in the long run is addressed and compared to those of other contemporary locations of the Kingdom of Valencia. Finally, the involvement of vassals in agriculture and ceramic manufacturing is also explored.
Developing effi cient grain disinfection devices based on the analysis of bioelectromagnetic interactions
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Pakhomov Aleksandr A.
Published: April 2023

The use of commonly used grain disinfection methods based on electromagnetic radiation is accompanied by high energy costs and insuffi ciently high-quality sterilization. The best characteristics have been demonstrated by a method of resonance-low-frequency disinfection, which needs to be eff ectively implemented taking into account the purpose of research. The analysis of bioelectromagnetic interactions showed the ineffi ciency of the solenoid due to the lack of Lorentz strength from the magnetic component and a weak and uneven electrical component. To avoid these shortcomings, the authors proposed improved solutions for the solenoid, evaluated the possibility of using multipolar electromagnets, and developed a new decontamination device with a uniform electrical component (E-fi eld). They also provided theoretically described the advantages of a new device based on the E-fi eld. An experiment was conducted on the disinfection of wheat grain at a plant with a capacity of 400 kg/h with a working fi eld frequency of 600 Hz. For a correct comparative assessment, the experiment was also conducted on an improved solenoid and a microwave installation Sigma-1. The results were subject to phytoevaluation conducted according to the standard methodology. Based on the experimental data, the authors determined the disinfection effi ciency coeffi cient, which was 280 for a new device, 16.6 for an advanced solenoid, and 2.3 for the Sigma-1 microwave unit. At the same time, the device based on the E-fi eld provided a reduction in the total contamination of the material with fungi and bacteria in 3.1 times, the improved solenoid - in 1.8 times. Power consumption was 30 and 410 watts, respectively. The experiment results confi rm the eff ectiveness of the new device based on the E-fi eld, which is characterized by low energy consumption, low metal consumption, simple design, and safe operation.
Performance of 20 rapid antigen detection tests to detect SARS-CoV-2 B.1.617.2 (Delta) and B.1.1.529 (Omicron) variants using a clinical specimen panel from January 2022, Berlin, Germany
Authors: Puyskens Andreas , Bayram Fatimanur , Sesver Akin , Michel Janine , Krause Eva , Bourquain Daniel , Filomena Angela , Esser-Nobis Katharina , Steffanowski Carla , Nübling C Micha , Scheiblauer Heinrich , Schaade Lars , Nitsche Andreas
Published: April 2023

Background

There are conflicting reports on the performance of rapid antigen detection tests (RDT) in the detection of the SARS-CoV-2 Omicron (B.1.1.529) variant; however, these tests continue to be used frequently to detect potentially contagious individuals with high viral loads.

Aim

The aim of this study was to investigate comparative detection of the Delta (B.1.617.2) and Omicron variants by using a selection of 20 RDT and a limited panel of pooled combined oro- and nasopharyngeal clinical Delta and Omicron specimens.

Methods

We tested 20 CE-marked RDT for their performance to detect SARS-CoV-2 Delta and Omicron by using a panel of pooled clinical specimens collected in January 2022 in Berlin, Germany.

Results

We observed equivalent detection performance for Delta and Omicron for most RDT, and sensitivity was widely in line with our previous pre-Delta/Omicron evaluation. Some variation for individual RDT was observed either for Delta vs Omicron detection, or when compared with the previous evaluation, which may be explained both by different panel sizes resulting in different data robustness and potential limitation of batch-to-batch consistency. Additional experiments with three RDT using non-pooled routine clinical samples confirmed comparable performance to detect Delta vs Omicron. Overall, RDT that were previously positively evaluated retained good performance also for Delta and Omicron variants.

Conclusion

Our findings suggest that currently available RDT are sufficient for the detection of SARS-CoV-2 Delta and Omicron variants.
Holding space with insomnia
Authors: Hopland Guidi Shelby
Published: April 2023

Exegesis
Like so many in my community, and around the world, I experienced COVID-19 – as a community member, as a student, and as someone who contacted the virus. While navigating the illness was difficult, for me the aftermath, and the arrival of insomnia as a symptom of Long COVID-19 is where my story begins. I was a Master of Social Work student, integrating my learnings into practice to become a therapist. I had to learn how to show up authentically and with competence, while having not slept, sometimes for days. Walking this line so often invited the question: How can I show up fully, when I am so empty? Beyond being able to show up, how could I hold space for all my family’s stories of COVID-19, while simultaneously having such a predominant story myself. Now, a year later, this poem is my journey of building an ongoing relationship with insomnia and my COVID-19 story so that I may hold my family’s stories as a family therapist – and for both to be tended to with gentleness and love.
PENDAMPINGAN GURU-GURU SMPN 4 MATARAM DALAM PEMBELAJARAN BAURAN MENUJU SEKOLAH BERBASIS IT (Model Sekolah Binaan)
Authors: Pepadu Jurnal , FItriana Eka , Nurtaat L. , Apgrianto Kurniawan , Saputra Agus , Khotimah Khusnul
Published: April 2023

Kegiatan Pengabdian Kepada Masayarakat ini bertujuan untuk meningkatkan kompetensi guru-guru SMPN 4 Mataram dalam mengelola pembelajaran bauran (Blended Learning) dengan berbasis Google Classroom yang dikombinasikan dengan aplikasi dan platform lainnya seperti Screencast O Matic, Camtasia, Canva dan Youtube guna memudahkan proses belajar pembelajaran. Kegiatan Pengabdian Kepada Masyarakat ini dilaksanakan dengan dengan memberikan pendampingan dan mentoring kepada semua guru mata pelajaran, Kegiatan Pengabdian Kepada Masyarakat ini dilaksakan dengan dipandu oleh 5 orang dosen dari Program Studi Pendidikan Bahasa Inggris FKIP Universitas Mataram. Kegiatan ini dilaksanakan dengan pemaparan pembelajaran bauran (Blended Learning) Selain itu kegiatan ini juga diisi dengan sesi diskusi, tanya jawab dan berlatih menggunakan aplikasi dan platform dengan smartphone maupun laptop. Dari pelaksanaan kegiatan Pengabdian Kepada Masyarakat ini dapat ditarik beberapa kesimpulan antaran lain: (1) Kegiatan Pengabdian Kepada Masyarakat ini telah dilaksanakan sesuai dengan perencanaan yaitu melibatkan semua guruguru mata pelajaran SMPN 4 Mataram (2) Para guru dikenalkan dan dilatih menggunakan berbagai aplikasi dan platform yang dapat menunjang proses belajar pembelajaran (3) Penggunaan aplikasi dan platform tersebut dapat menggunakan smartphone maupun laptop.
PENYULUHAN PERILAKU HIDUP BERSIH DAN SEHAT DALAM RANGKA MENGURANGI ANGKA STUNTING DI DESA ANDALAN KECAMATAN BAYAN KABUPATEN LOMBOK UTARA
Authors: Pepadu Jurnal , Ayunin Novita Indah Kurata , Puspitasari Candra Eka , Turisia Nadya Arianita
Published: April 2023

Sanitasi yang buruk dapat berdampak pada risiko stunting pada kesehatan masyarakat. PHBS merupakan suatu langkah yang dapat dilakukan untuk mencapai derajat kesehatan yang optimal bagi setiap individu. Kabupaten Lombok Utara (KLU) merupakan salah satu kabupaten dengan tingkat stunting tertinggi di Nusa Tenggara Barat yakni sebesar 37,6%. Tujuan dari penyuluhan ini adalah untuk mengedukasi dan mengimplementasikan PHBS untuk mencegah stunting. Metode yang digunakan dalam kegiatan ini adalah melakukan observasi permasalahan sanitasi di Desa Andalan kemudian melakukan penyuluhan dan demonstrasi indikator PHBS. Hasil observasi menunjukkan bahwa sanitasi masyarakat Desa Andalan buruk dibuktikkan dengan masih banyak masyarakat yang membuang sampah sembarangan dan masih banyak masyarakat yang membuang air sembarangan atau sebagian masyarakat tidak memiliki jamban. Kesimpulan dari penyuluhan ini adalah penerapan PHBS di Desa Andalan sudah cukup baik walaupun masih ada masyarakat yang belum menerapkan PHBS.
OPTIMALISASI PEMANFAATAN PEKARANGAN RUMAH SEBAGAI UPAYA PENINGKATAN KETAHANAN PANGAN DAN PENDAPATAN RUMAH TANGGA DI DESA DASAN TERENG, KECAMATAN NARMADA
Authors: Pepadu Jurnal , Nikmatullah Aluh , T. Sofyan , A. Fina , I. Osi , A. Meli , Hardriansyah M. , R. Baiq Yusmi A. , A. Avida I. , P. Ida Ayu Vigi M. , A. Zakiah , A. Miana Y. , Z. Elvin A. , N. Safira
Published: April 2023

Di desa Dasan Tereng, pemukiman penduduk cukup padat dengan pekarangan yang tidak luas dan masyarakat desa belum memaksimalkan pemanfaatan pekarangan rumahnya. Hal ini disebabkan oleh pengetahuan, minat pemanfaatan pekarangan yang rendah dan juga disebabkan karena motivasi serta keinginan untuk melakukan budidaya di lahan pekarangan. Pada kondisi pandemic covid-19 saat ini, peningkatan imunitas sangat penting untuk menjaga kesehatan dan produktivitas masyarakat, dan pekarangan dapat dimanfaatkan untuk budidaya tanaman obat dan rempah yang dapat meningkatkan imunitas serta berpotensi memberikan peluang usaha bagi peningkatan pendapatan rumah tangga. Budidaya di lahan pekarangan membutuhkan wadah budidaya, media budidaya dan pupuk/pestisida untuk menjaga agar tanaman tumbuh dengan subur. Bahan-bahan tersebut apabila dibeli membutuhkan biaya yang cukup tinggi, padahal rumah tangga berpotensi menghasilkan bahan baku untuk wadah budidaya, media tanam organik, pupuk organik dan pestisida nabati. Bahan-bahan tersebut apabila tidak dimanfaatkan akan menjadi limbah yang dapat menimbulkan masalah lingkungan dan kesehatan. Oleh karena itu, mahasiswa KKN Tematik Universitas Mataram 2021/2022 melakukan pendampingan kepada masyarakat di Desa Dasan Tereng, Kecamatan Narmada untuk Optimalisasi Pemanfaatan Pekarangan Rumah sebagai Upaya Peningkatan Ketahanan Pangan Dan Pendapatan Rumah Tangga. Pendampingan bertujuan untuk memberikan motivasi, meningkatkan pemahaman dan mendampingi masyarakat Desa Dasan Tereng untuk mengoptimalkan pemanfaatan lahan pekarangan rumah sebagai upaya peningkatan ketahanan pangan dan pendapatan keluarga. Kegiatan pendampingan meliputi sosialisasi, demonstrasi dan pendampingan budidaya di pekarangan secara vertikultur dan pengolahan tanaman rempah serta obat menjadi jamu. Pada kegiatan ini didemonstrasikan pemanfaatan botol plastik bekas untuk wadah budidaya serta sampah organik menjadi ekoenzim.
Impact of Heat Units on the Phenology and Yield of Baby Corn (Zea mays L.) in Western Agro Climate Zone of Tamil Nadu
Authors:   Agro Climate Research Centre, Tamil Nadu Agricultural University, Coimbatore-641003, Tamilnadu, India, P ARUNKUMAR , S KOKILAVANI ,   Agro Climate Research Centre, Tamil Nadu Agricultural University, Coimbatore-641003, Tamilnadu, India, N KOWSHIKA ,   Agro Climate Research Centre, Tamil Nadu Agricultural University, Coimbatore-641003, Tamilnadu, India, SP RAMANATHAN ,   Agro Climate Research Centre, Tamil Nadu Agricultural University, Coimbatore-641003, Tamilnadu, India, T SANKAR ,   Agro Climate Research Centre, Tamil Nadu Agricultural University, Coimbatore-641003, Tamilnadu, India
Published: April 2023

Field investigation was carried out during winter 2022 at Tamil Nadu Agricultural University, Coimbatore to study the phenological behaviour and yield of baby corn (Zea mays L.) as influenced by heat units. The split-plot design consisting of three dates of sowing viz., D1 – 21st January, D2 – 5th February and D3 – 20th February as a main plot and three spacing viz., 60x45 cm (S1), 60x30 cm (S2) and 60x20 (S3) as a sub plot was adopted and replicated thrice. Growing Degree Days, Helio Thermal Unit and Heat Use Efficiency were calculated for different phenological stages viz., plant emergence to 50% flowering (P1), 50% flowering to cob emergence (P2), cob emergence to harvest (P3), plant emergence to cob emergence (P4), 50% flowering to harvest (P5) and plant emergence to harvest (P6). The results revealed that sowing on 20th Feb. had completed the phenophases early, followed by 5th Feb and 21st Jan. GDD required for attaining physiological maturity was highest in 20th Feb. (1194.6 ºC days)). Except morning relative humidity, wind speed and solar radiation, all other weather parameters had negative correlation with baby corn yield (R2=0.921). The optimum temperature was obtained during D1 (27.2 – 27.5 ºC) along with short-day length (11.7 hours) resulting in higher corn yield (9333.3 kg/ha) as well as higher HUE (5.75).
EXPERIENCIA FORMADORA CON CUATRO GUÍAS DE BUENAS PRÁCTICAS CLÍNICAS DE LA REGISTERED NURSES’ ASSOCIATION OF ONTARIO
Authors: Díaz Videla Valeria , Leiva Castillo Jacqueline , Pérez González Cristian , Andrade Uribe Flora , Sepúlveda Barra Paola
Published: April 2023

El presente artículo trata sobre la implementación de cuatro guías elaboradas por la Registered Nurses’ Association of Ontario (Canadá) en la enseñanza de pregrado de la Carrera de Enfermería de la Universidad de Chile, proceso que se enmarca en el primer convenio establecido entre la Universidad de Chile y esta asociación. El acuerdo instaurado entre ambas instituciones promovió la incorporación de las guías: Valoración y Selección de Accesos Vasculares, Atención a las Familias, Establecimiento de Relación Terapéutica, y Valoración y Manejo del Dolor, al plan de formación de la Carrera de Enfermería, proceso liderado por docentes asesores de cada una de las guías a través de diversas estrategias pedagógicas y didácticas, demostrando un aporte significativo de este material al aprendizaje de los estudiantes de enfermería de la institución académica
Extraction of Water Bodies from Sentinel-2 Images in the Foothills of Nepal Himalaya
Authors: Lekhak Kumod , Rai Pawan , Budha Padam Bahadur
Published: April 2023

This paper evaluates an integrated water body mapping method in sub Himalayan region of Nepal with optical images of Sentinel – 2 satellites of European Space Agency. The objectives of this study is to evaluating the integrated method of water body mapping with Sentinel – 2 data and to find the optimal mapping method in Sub Himalaya region. This method extracts the information on water bodies by combining image indices and near infrared band and used slope image to remove false results.. The study results indicate that difference of indices is more accurate to map the water bodies than single index method as it enhance the contrast between water bodies and other environmental features. On the basis of the accurately mapped water bodies of the study area, this research conclude that the multi spectral images from the Sentinel images can be ideal data source for water bodies monitoring with fine spatial and temporal resolution. Although smaller water bodies with high vegetation cover cannot be detected by this method, the integrated water body mapping method is suitable for the applications multi-spectral images in this field.
Phenotypic variability of Linum usitatissimum l. accessions under the conditions of the Northern Trans-urals
Authors: Korolev K. P. , Bome N. A. , Kolokolova N. N.
Published: April 2023

Background. One of the ways to increase flax production is to expand cropping areas, including nontraditional ones. To solve this problem, it is necessary to carefully select cultivars that can produce stable high yields and have competitive raw material quality. The aim of this study was to identify the adaptability potential of flax accessions and select sources of valuable properties for their use under the conditions of the Northern Trans-Urals.Materials and methods. Sixty flax accessions were studied in the fields of the south of Tyumen Province in 2017–2020. Phenotypic screening was performed according to the published lists of descriptors, taking into account outdoor seed germination, plant height, seed yield, flax straw, retted stalks, and fiber. Statistical data processing included the multivariate analysis of variance and correlation analysis. Environmental screening was performed according to S. A. Eberhart, W. A. Russell.Results and conclusion. Based on the long-term data, sources of traits were identified: 4 for outdoor seed germination, 4 for plant height, 11 for the duration of the growing season, 21 for straw yield, 19 for the yield of retted stalks, 9 for seed yield, 6 for total fiber yield, and 5 for 1000 seed weight. The manifestation of traits was shown to be largely induced by the impact of the environment factor and the complex genotype × environment interaction. On the basis of screening results, 12 accessions were selected. The correlation analysis helped to find out that on average over the years of research there were high and stable direct relationships of the yield of straw (r = 0.73–1.00) and retted stalks (r = 0.68–1.00) with plant height. Under relatively favorable conditions for plant growth and development during the growing seasons of 2017 and 2020, the influence of outdoor seed germination on plant height (r = 0.62–1.00), straw yield (r = 0.78–1.00), and seed yield (r = 0.52–0.91) increased.
Etiología y sensibilidad antibiótica en colangitis aguda
Authors: Acosta Juan David , Díaz Jesús Eduardo , Bastidas Beatriz Eugenia , Merchán Galvis Ángela María
Published: April 2023

Introducción. El dolor abdominal constituye una causa frecuente de consulta y, en el Cauca, es el quinto motivo de consulta y hospitalización. Las infecciones de la vía biliar son una causa significativa de la bacteriemia y mortalidad secundaria; de allí, la importancia de instaurar una terapia antibiótica temprana y apropiada. Se buscó describir los gérmenes más frecuentemente aislados en los cultivos de bilis y hemocultivos de pacientes con colecistitis aguda grave, colangitis o ambas, del Hospital Universitario San José entre diciembre de 2013 y diciembre de 2014, y conocer su perfil de sensibilidad o resistencia a los antibióticos.

Materiales y métodos. Este fue un estudio descriptivo, de corte transversal, de pacientes con diagnóstico de colangitis aguda y colecistitis grave, del Hospital Universitario San José, que fueron hospitalizados en el periodo de diciembre de 2013 a diciembre de 2014. Se tomaron cultivos de bilis y hemocultivos, y se hizo el antibiograma de los antibióticos más utilizados en el hospital.

Resultados. Se estudiaron 106 pacientes, de los cuales hubo 49,1 % con cultivos positivos de bilis y 19 % con hemocultivos positivos. Los gérmenes más frecuentemente aislados fueron Escherichia coli (51,42 %), Klebsiella pneumoniae (17 %) y otros bacilos Gram positivos.

Discusión. Los resultados de este y otros estudios reflejan que, a pesar de compartir el agente causal de infección en la vía biliar, la identificación de dichos microorganismos por pruebas de laboratorio y su sensibilidad antibiótica varía considerablemente, lo que puede asociarse con el lugar de residencia, el tipo de tratamiento antibiótico usado regularmente en cada centro hospitalario y su duración.
Tumor mucoso apendicular
Authors: Ángeles Pedro Diego , Vega Ximena , Palacios José
Published: April 2023

Los tumores mucosos apendiculares tienen baja incidencia y comúnmente se diagnostican en el estudio anatomo-patólogico después de la apendicectomía. Se reporta el caso de una mujer de 41 años de edad, con un cuadro clínico de ocho meses de evolución, caracterizado por dolor abdominal de tipo opresivo, difuso y de gran intensidad en el hemiabdomen inferior, acompañado de náuseas. Después de cinco meses de iniciado este cuadro clínico, se evidenció una masa en la fosa iliaca derecha; el dolor se agudizó e intensificó, y las náuseas continuaron, por lo cual fue remitida al hospital. En los exámenes practicados se observó una masa quística compleja abdomino-pélvica de origen indeterminado, y la tomografía computadorizada de abdomen fue sugestiva de mucocele apendicular. Con estos hallazgos, se optó por el tratamiento quirúrgico por laparotomía, consistente en hemicolectomía derecha, con resección parcial de íleon, epiplectomía, histerectomía y salpigooforectomía bilateral