bluuebunny/crossref_metadata_2025 huggingface dataset:
Socio Demographic Profiles of Enuresis among Primary School Children
Authors: Mustapha Audu Hadiza
Published: April 2022

Enuresis is defined in many different ways, but the common thread to all involves a lack of bladder control after 5 years of age, an age when most children would be expected to have achieved bladder control. Nocturnal enuresis is best regarded as a condition with different etiologies. Many aetiological theories have been proposed, with the cause of nocturnal enuresis now regarded as heterogeneous. This was a cross-sectional, descriptive study of primary school children aged between 6-12 years. The study was conducted in Borno State in the northeastern part of Nigeria, West Africa. The sample size is 560, with 260(52.1%) males and 239 (47.9%) females. The ages of the respondents ranged from 6 to 12 years, with a mean age of 9.47 years and a Standard Deviation (SD) of ±1.85. Nine variables, namely age, gender, home environment, maternal education/occupation, paternal education/occupation, family size, and family history of enuresis among siblings at 95% CI were considered. The variables that have a significant relationship with enuresis when the chi 2 test was used were further subjected to logistic regression analysis. The children’s sex, age group, family history, fathers’ education, and occupation were found to have statistical significance in predicting bedwetting among children. Health educators and primary care health staff should obtain detailed history not to miss patients with enuresis, and parents should be informed about the psychological effects of Enuresis and to seek appropriate treatment for their children.
Perception and Knowledge of Cancer and Cancer Screening among Staff of Military Hospital Lagos
Authors: Oladiran Abiola Ajoke Odeleye
Published: April 2022

Perception and knowledge of cancer remain poor in developing countries. Problems associated with cancer incidence include late reporting due to fear, ignorance and financial constrains relating to cancer screening. This study sought to determine the perception and knowledge of cancer among health workers in Lagos. Method: A mixed-method study design comprising a qualitative study (Focus Group Discussions and In-depth Interview) and a quantitative study was employed to collect information from the staff of Military Hospital Lagos, southwest Nigeria. 30 Participants for the qualitative study were purposely recruited, while 200 participants for the quantitative study were selected using the proportional probability sampling technique after approval was received from the management of the hospital. Qualitative data was recorded using a recorder, transcribed verbatim, and analyzed thematically. Quantitative data was analyzed using SPSS 25.0 software at 95% CI, alpha set at 5%. Findings: The majority were women, 16(64.0%), with only 8(27%) of them under health insurance, with a minimum qualification of secondary school certificate, and mostly health attendants in the group discussion, while those in the interview group were all health professionals. The quantitative study revealed more males 106(53.0%), 73(36.5%) between 20-30 years, with 114(57.0%) married, over half, 122(61.0%) possessed a college degree, average income being >50-100 thousand naira monthly, 132(66.0%) respondents had health insurance. All cited fear and death sentence on hearing “cancer”, most had limited knowledge about cancer screening, only 5(2.5%) had any screening in the last 6 months.
Mental and Technical Readiness of Freshmen Nursing Students in an Online Learning Modality
Authors: Malabarbas Gerald T.
Published: April 2022

The Covid-19 pandemic opens more windows to online learning globally. With this, all countries have shifted their educational setup to online learning modalities due to this pandemic. This study assessed the level of mental and technical readiness in the online learning modality of freshmen nursing students in one of the catholic private institutions in the Philippines. The researchers made use of descriptive research. An adapted questionnaire was used as a data-gathering tool but subjected to a reliability test. Results revealed that most of the respondents were female, graduated from the STEM strand, and belong to poor families. It further disclosed that for the mental dimension, the students were ready, and for the technical dimension, they were only somewhat ready. Additionally, inferential statistics showed that among the student’s profiles, the family’s monthly income showed a significant difference specifically between the poor and the lower-middle-income group both in mental and technical dimensions. The proposed psycho-social programs were focused on the topmost indicators that obtained the lowest mean scores among indicators observed, such as the presence of distractions, spending 20-30 hours each week on an online course, and availability of reliable person around, lack of a printer, stable internet connection, and the student’s device compatibility needed for online learning. Thus, the researchers highly recommend that the institution should intensify its orientation program on the use of the learning management system of an online learning modality and improve its program on mental health issues for both students, parents, and teachers.
Uptake of Cancer Screening among Staff of Military Hospital Lagos
Authors: Oladiran Abiola Ajoke Odeleye
Published: April 2022

The uptake of cancer screening services remains poor in developing countries due to altered perception and awareness of cancer. Difficulties associated with cancer screening include late reporting due to fear, ignorance, cost, and cultural issues. This study sought to establish the utilization of cancer screening services among health workers in Military Hospital Lagos (MHL) and the reasons for poor utilization of such services. Method: This quantitative study utilized 200 participants in MHL, Southwest, Nigeria to collect information. Proportionate probability sampling was used to determine those needed from each department and then conveniently selected after approval was received from the management of the hospital. Data was analyzed using SPSS 25.0 software at 95% CI with an alpha set at 5%. Findings: Participants were mostly males 106 (53.0%), between the age range of 20-30 years 73(36.5%), mostly married 114 (57.0%), with 122(61.0%) possessing a college degree, 90(45.0%) having average income >50-100 thousand naira and 132(66.0%) possessing health insurance. Major factors identified for influencing screening utilization were fear of a positive result, ignorance, belief in not being at risk, having many contending issues, nonchalant attitude to health, financial constraint. Conclusion: A low level of cancer screening and uptake was noticed among these health workers. This raises the need for urgent enlightenment about cancer screening even among health workers, and cancer screening made more available and affordable with easy accessibility to reduce the incidence and mortality of invasive cancer.
Occupational Wellness and its Determinants among Cocoa Farmers in South-West Nigeria
Authors: Kuye Joseph
Published: April 2022

Occupational wellness is essential for cocoa farmers’ health and productivity since a significant proportion of their time is spent at work. It is a measure of individual wellbeing, focusing on the psychosocial status as it relates to individuals’ profession. This study assessed occupational wellness and its determinants among cocoa farmers in the South-West region of Nigeria. A descriptive cross-sectional study design was used to study 244 cocoa farmers in Ekiti and Osun States. Also, the local government areas were purposively selected as being well known for cocoa production. A semi-structured interviewer-administered questionnaire was used to obtain data on sociodemographic characteristics and occupational wellness. Occupational wellness was scored based on their response to eight sets of questions with a 4-point Likert scale response. Association between the farmers’ characteristics and occupational wellness was assessed using Mann Whitney U and Kruskal Wallis tests. Determinants of occupational wellness were assessed using quantile regression. The median occupational wellness score was 25.0 (IQR = 24.0 – 29.0). People of low educational status had higher occupational wellness scores, p < 0.001. Significant associations were also observed between other characteristics like sex, religion, marital status, geographical location, farm ownership, and occupational wellness. Farm ownership was also a significant determinant of occupational wellness. The occupational wellness status is due to a complex mix of occupational factors, sociodemographic factors, and geographic factors. Health promotion will be key in maintaining a balance of the mix to enhance the general wellbeing and productivity of the farmers.
Pain Experience and Coping Strategies Employed by Women in Labor in a Secondary Health Facility in Ilorin, Kwara State, Nigeria
Authors: A Onasoka, Olyinka
Published: April 2022

Labour pain experience is distinctive and complex, and women use various coping strategies to cope with it. Hence, this study attempted to explore pain experience and coping strategies employed by women in labor in a secondary health facility in Ilorin, Kwara State, Nigeria. A qualitative exploratory research design was used, and a purposive sampling technique was used to select a total of ten (10) mothers who delivered within 48hours in the healthcare facility. A total of three FGD sessions were conducted, each had between 3 and 4 participants. The semi-structured interview guide was used for data collection, and the data were analyzed using content analysis. The women who participated in this study were between 20 and 42years of age, and they perceived labour pain differently. Some of the women described labour pain as very painful; others said the pain is normal, while some said the pain cannot be compared with anything. The study revealed that younger women who are primiparous perceived labor pain as more severe than the multiparous women. All the participants said that birth information and instructions received from the midwives, as well as the presence of caring midwives, help to relieve labour pains and consequently influence their pain experience(s) positively. The coping strategies used varied among participants, and deep breathing techniques, relaxation, and vertical positions were the major coping strategies used. Therefore, the provision of adequate labour information on coping strategies and the presence of caring midwives influenced the labour experience(s) positively.
An Assessment of the Factors that Contribute to Non-Adherence to Ant-Retroviral Therapy (Art) Treatment among HIV Patients at Nchanga North General Hospital-Chingola, Zambia
Authors: Musonda Judith
Published: April 2022

The research study was aimed at assessing the factors that contribute to non-adherence to Ant-Retroviral Therapy (ART) treatment among HIV patients at Nchanga North General Hospital-Chingola. With regards to the objectives, they were to establish the individual factors, social-cultural factors, social-economic factors, environmental factors, and health care provider factors contributing to non-adherence to Ant-Retroviral Therapy (ART) treatment among HIV patients. A descriptive cross-sectional design that was quantitative in nature was used for the study. The study targeted 162 non-adherent patients. In collecting data, structured questionnaires were used. A purposive sampling technique was used to select 115 respondents. The collected data was entered into data sets and analysed using Statistical Package for Social Sciences (SPSS) version 23.0 software to dissolve the portents and to evaluate the extent of ART non-adherence amongst male patients. The study concluded that non- adherence at Nchanga North Hospital is brought about by factors such as individual factors, social-cultural factors, social-economic factors, environmental factors, and health care provider factors. The research recommends that patient’s preventive interventions such as community adherence supporter programs ought to be developed and implemented for the purposes of improving and ensuring ART adherence.
Perception and Hypertension Prevention Practices of Teachers in selected Secondary Schools in Sagamu Local Government Area Ogun State, Nigeria
Authors: Dankoli Raymond Salanga
Published: April 2022

Prevention of Hypertension is important for reducing the high prevalence and incidence of Hypertension and can help reduce resultant morbidities and consequences of cardiovascular disorders. This study assessed the perception of teachers on hypertension prevention in selected secondary schools in Sagamu Local Government Area, Ogun State, Nigeria. The study employed a descriptive cross-sectional design. A Multi-stage sampling technique was used to select 418 respondents for the study. A validated semi-structured questionnaire was used for data collection. Descriptive and inferential statistics was used to analyze the data collected at ≤0.05 level of significance. The respondents had a mean age of 42.61±7.79 years, with 313 (74.9%) of them having a bachelor’s degree. The respondents’ perception of hypertension prevention measured on a 72-point rating scale showed that the respondents had a mean score of 47.10±8.48. Most 225(53.8%) of the respondents had a moderate perception of hypertension prevention. The respondents’ hypertension prevention practices measured on a 24-point rating scale showed that the respondents had a mean score of 15.34±4.95. Less than half 184(44.0%) of the respondents had moderate hypertension prevention practices. Furthermore, there is a significant relationship between respondents’ perception and their hypertension prevention practice. The study revealed that the majority of the respondents had moderate perception of Hypertension and moderate prevention practices of Hypertension. It is recommended that the state ministry of education through the state ministry of health should conduct health education and promotion programs among teachers to change their perception of hypertension prevention which will, in turn, influence their prevention practices.
Effects of Pregnancy-Induced Psychological and Emotional Factors on the Occurrence of Preeclampsia/Eclampsia (PE-E) and Haemorrhage
Authors: Avoka James Atampiiga
Published: April 2022

Preeclampsia/eclampsia (PE-E) and haemorrhage are the topmost causes of maternal and perinatal deaths in the world. This study was designed to assess the effects of pregnancy-induced psychological and emotional factors on the occurrence of PE-E and haemorrhage. The study was a prospective cohort involving all pregnant women >28 weeks of gestation reporting for antenatal care (ANC) in seven Hospitals in the Eastern Region of Ghana. The study redesigned the Revised Cognitive Therapy Scale (CTS-R) to suit this study using a five-point score scale. The results show that the predictor variables; fear, anger, sadness, disgust, love, hate, tension, anxiety, depression, and dejection, were all statistically significant and associated with PE-E and haemorrhage except joy, acceptance, and happiness. Pregnant women who experienced high (2) and highest (4) levels of fear had reduced odds of PE-E by 34% and 15.8%, respectively. Those who recorded low levels of love were 9.8 times the odds of PE-E, those with low (1), high (2), higher (3), and highest (4) levels of anxiety had reduced odds of PE-E by 22.2%, 37.3%, 21.3%, and 10% respectively. Pregnant women with low levels of psychological and emotional issues were about 3 times the odds of PE-E compared to those who were normal. In conclusion, the study shows a significant association between preeclamptic/eclamptic pregnant women and different levels of fear, anger, sadness, Love, hate, depression, dejection, anxiety, and tension. It is recommended that Ghana Health Service should institute psychological and emotional counselling as part of ANC services in order to manage pregnant women who may need them to avert the effects on pregnancy and birth outcome.
Discrimination and Stigma of Mentally Ill Patients among Health Care Workers and the Public in Developing Countries; its Effect on the Integration of Mental Health Services into the Primary Health Care System- A Systematic Review
Authors: Maloney Roxanne Stowe
Published: April 2022

Discrimination and stigmatization against the mentally ill are issues of concern for years and have negatively affected the health outcomes of the mentally ill. The WHO has advised that integration of mental health services is necessary to close the treatment gap that currently exists. The aim of this paper is to synthesize evidence from various researchers regarding the presence of discrimination and stigma of mentally ill patients among health care workers and the public and to identify its effect on the integration of mental health services into the primary health care system. A systematic search was conducted in the PubMed, EBSCO HOST, Google scholar, MEDLINE databases. Fifteen (15) studies were evaluated to determine the level of stigma and discrimination towards the mentally ill patient by health professionals and the public. Studies conducted in developing countries identified that stigma and discrimination against the mentally ill among health care workers and members of the general public exists, and this negatively affects the integration process. Fear of seeking help from the health care service providers and administration of poor quality of health care to this category of patients are some of the effects. Stigma and discrimination are still major issues in developing countries; it is imperative that means of resolving these issues are developed. The gap in mental health treatment exists and is growing. Education: increased public awareness and good governance of the health system are just a few ways in which we can resolve these problems.
A politika, az oktatásügy és a neveléstudomány az 1950-es, ’60-as és ’70-es évek szocialista Jugoszláviájában (Vázlat)
Authors: Sütő Erika
Published: April 2022

A tanulmány a vizsgált korszak politikai-társadalmi jellemzőinek tükrében elemzi a jugoszláv szocialista oktatáspolitikai történéseket. Azokkal a pedagógiai és politikai-ideológiai folyamatokkal foglalkozik, amelyek az elemzett időszakban hatást gyakoroltak a közoktatásra. A második világháború után a gyökeres politikai-ideológiai változások igazodtak a Jugoszláv Kommunista Párt és Tito hatalmi érdekeihez, ennek függvényében többször módosítottak az alkotmányon, a törvényeken, az oktatási rendszeren. A decentralizációs és centralizációs folyamatokat a szakirodalmi feldolgozások, politikai dokumentumok, törvények mellett az ’50-es évek tantervének és a ’70-es évek tanterveinek összehasonlításával mutatjuk be.
A pénzügyi kultúrát fejlesztő képzések és minőségbiztosítottságuk
Authors: Németh Erzsébet , Deák-Zsótér Boglárka , Vargha Bálint Tamás
Published: April 2022

Az Állami Számvevőszék 2016-ban, majd 2020-ban felmérte és értékelte a hazai pénzügyi kultúra fejlesztését célul tűző programokat, azok minőségét, eredményességét. Az eredmények azt mutatják, hogy 2016 és 2020 között számos előrelépés történt: több állami és egyéb kezdeményezés indult meg, a képzések volumene, a képzési programok és az azokon részt vevők száma jelentősen nőtt. Nem változott azonban érdemben a képzések minőségbiztosítottsága. 2020-ban több hosszabb képzés volt elérhető a felnőttek számára, az iskoláskorúak képzései azonban továbbra is 1-4 órásak maradtak. A képzések négyötödében van tananyag és tematika, de ezek többsége nem akkreditált, és nem érhető el nyilvánosan. A képzések mintegy 40%-a értékeli az eredményességet. A minőségbiztosítás alapjául szolgáló dokumentáció egyes fontos eszközei (nyilvánosan elérhető tematika, tananyagok akkreditációja, oktatói felkészítés programja és a hallgatói előzetes igényeket és/vagy tudást vizsgáló eszköz) megléte a közpénzt felhasználó képzéseknél elterjedtebbek, ezek a képzések azonban kevésbé értékelik az oktatás eredményességét. A kutatás eredményei ismételten jelzik, hogy szükség van a képzések minőségét szavatoló szakmai garanciák további erősítésére. A közpénzzel is gazdálkodó szervezetek képzéseinél indokolt előírni, hogy mérjék a képzések eredményességét, és biztosítsák a tematikák és a tananyagok minőségét és széleskörű elérhetőségét.
Evolutionary mechanisms and shifting trends in water circulation patterns in a tributary of the Three Gorges Reservoir, China
Authors: Ijaz U. , Cheng Z. , Qiu S. , Ayub H.
Published: April 2022

A 2-D CE-QUAL-W2 hydrodynamic model was established to simulate evolutionary mechanisms and shifting trends of flow patterns per annum and over seasons from 2008 to 2018 in a reflective tributary Xiangxi Bay (XXB) of the Three Gorges Reservoir, China. Reasons behind shifting trends of flow patterns were also investigated. Model performance was validated and simulated data was synchronous to observed data. In general, percentage of Pattern (6) was 14%, 20%, 17%, 12% and 11% per annum and in spring, summer, autumn and winter respectively by 2013. It was increased by 26%, 30%, 22%, 25% and 35% per annum and in spring, summer, autumn and winter respectively since 2014. Increased temperature and flow dynamics (such as 10,000 m3 s−1 in spring) in Three Gorges Resevoir (TGR) since 2014 were underlying shifting trends of density current patterns. Correlation among patterns prior to and after newly built upstream reservoirs was novel and innovative in finding hydrodynamic thresholds to increase effectivity. Particulars elaboated and associated with respective density current patterns indicate increased surface velocity and water exchange with increased overflows. This could help understanding hydrodynamics and ecological variations in TGR and XXB. Thermal establishment and flow dynamics in TGR triggering overflow intrusion in XXB are required to be achieved. A hydrodynamic and water quality model of XXB coupled with TGR mainstream is recommended to correlate additive impacts of advantageous and disadvantageous patterns and to evaluate hydrodynamical thresholds triggering advantageous patterns in XXB.
Pharmacology of Cannabinoid Receptor Ligands
Authors: Pertwee Roger G.
Published: April 2022

Mammalian tissues contain at least two types of cannabinoid receptor, CB1 and CB2 , both coupled to G proteins. CB1 receptors are expressed mainly by neurones of the central and peripheral nervous system whereas CB2 receptors occur in certain non-neuronal tissues, particularly in immune cells. The existence of endogenous ligands for cannabinoid receptors has also been demonstrated. The discovery of this 'endogenous
cannabinoid system' has been paralleled by a renewed interest in possible therapeutic applications of cannabinoids, for example in the management of pain and in the suppression of muscle spasticity/spasm associated with multiple sclerosis or spinal cord injury. It has also prompted the development of a range of novel cannabinoid receptor ligands, including several that show marked selectivity for CB1 or CB2 receptors. This review summarizes current
knowledge about the in vitro pharmacological properties of important CB1 and CB2 receptor
ligands. Particular attention is paid to the binding properties of these ligands, to the efficacies of
cannabinoid receptor agonists, as determined using cyclic AMP or [35S]GTPγS binding assays, and to selected examples of how these pharmacological properties can be influenced by
chemical structure. The in vitro pharmacological properties of ligands that can potently and
selectively oppose the actions of CB1 or CB2 receptor agonists are also described. When administered by themselves, some of these ligands produce effects in certain tissue preparations that are opposite in direction to those produced by cannabinoid receptor agonists
and the possibility that the ligands producing such 'inverse cannabimimetic effects' are inverse agonists rather than pure antagonists is discussed.
Cannabimimetic Fatty Acid Derivatives: The Anandamide Family and Other 'Endocannabinoids'
Authors: Melck D. , Di Marzo V. , Bisogno T. , De Petrocellis L. , Martin B.R.
Published: April 2022

In agreement with the highly lipophilic nature of (-)-Δ-9-tetrahydrocannabinol, all the endogenous ligands of cannabinoid receptors identified so far are derivatives of long chain fatty acids. N- Arachidonoylethanolamine (anandamide) and some of its polyunsaturated congeners have been found in mammalian brain and shown to activate the CB1 and, with a lower efficacy, CB2 cannabinoid receptor subtypes. More recently, 2-arachidonoylglycerol (2-AG), a widespread intermediate in the metabolism of phosphoglycerides, diacylglycerols and triglycerides, was also found to activate the cannabinoid receptors. The capability of palmitoylethanolamide, an anti-inflammatory metabolite, to activate CB2-Iike receptors is still being debated. Here we review: 1) the metabolic pathways suggested so far to underlie the biosynthesis and inactivation of anandamide and 2-AG, and 2) the current knowledge of the chemical bases for the interactions of anandamide and 2-AG with proteins of the 'endogenous cannabinoid system' characterized so far, i.e. the CB1 and CB2 receptor subtypes, the membrane 'anandamide carrier', which facilitates anandamide diffusion into cells, and the enzyme 'fatty acid amide hydrolase', which catalyzes anandamide and, to a certain extent, 2-AG hydrolysis in vivo.
The Development of Cannabinoid Antagonists
Authors: Barth Francis , Rinaldi-Carmona Murielle
Published: April 2022

The discovery of two distinct cannabinoid receptors (CB1 and C B 2 ) in the early 1990's has revived the research on cannabinoid antagonists. While the search for antagonists based on the structure of agonists (classical cannabinoids or aminoalkylindoles) appeared rather disappointing, the first potent cannabinoid antagonists were developed in a new chemical series: the diarylpyrazoles. Since its discovery in 1994, the selective CB1 antagonist SR 141716 has become a major pharmacological tool to elucidate the physiological role of the CB 1 cannabinoid receptor and its endogenous ligand. The selective CB2 antagonist SR 144528 is expected to play the same role for the CB2 receptors, while the recent development of cannabinoid antagonists belonging to other chemical series illustrates the interest of these compounds which are now considered as interesting therapeutic targets by many pharmaceutical companies.
Local Delivery of Metronidazole-loaded N-Trimethyl Quaternary Ammonium
Chitosan Nanoparticles for Periodontitis Treatment
Authors: Garg Kritika , Tirgar Pravin
Published: April 2022

Background:

Recent findings suggest that chitosan has shown antibacterial activity acting
through various mechanisms, but when the amine group in chitosan is converted to quaternary ammonium
compound, the antibacterial activity of chitosan is elevated due to the increase in its solubility in
an acidic environment.

Objectives::

The purpose of this study was to formulate and standardize metronidazole-loaded Ntrimethyl
quaternary ammonium chitosan nanoparticles for the treatment of periodontitis.

Method:

N-trimethyl quaternary ammonium chitosan derivative was synthesized, and nanoparticles
(NPs) were prepared by ionic gelation methodology followed by 32 full factorial designs. Particle size,
zeta potential, polydispersity index (PDI), surface morphology, thermal properties, in vitro drug release
as well as antimicrobial activity, stability study, ex vivo, and acute toxicity of NPs were evaluated.

Results:

The optimized batches of NPs were in the size range of 150 to 237 nm with a mean size of
117.01 ± 0.03 nm. Entrapment efficiency (EE) of 81.45 ± 0.03 % was obtained with a zeta potential
(mV) of 28.19 ± 0.03 mV. Almost 98.97 ± 7.17% of the drug was released within 24 hours in vitro to
obtain a sustained release drug; the optimized batches exhibited a smooth surface with appreciable in
vitro, ex vivo antibacterial, and acute toxicity, and it was found that the formulation could be stored for
up to 6 months.

Conclusion:

The present study revealed that metronidazole-loaded N-trimethyl quaternary ammonium
chitosan nanoparticles exhibit enhanced antibacterial activity against periodontal infections.
Does Gut-breast Microbiota Axis Orchestrates Cancer Progression?
Authors: Marino Maria Michela , Nastri Bianca Maria , D’Agostino Marina , Risolo Rossella , De Angelis Alessandra , Settembre Giuliana , Rienzo Monica , D’Esposito Vittoria , Abbondanza Ciro , Formisano Pietro , Ballini Andrea , Santacroce Luigi , Boccellino Mariarosaria , Di Domenico Marina
Published: April 2022

Breast cancer, even today, can cause death. Therefore, prevention and early detection
are fundamental factors. The mechanisms that favour it are genetic and epigenetic, and seem to
play a significant role; also, the microbiota can change estrogen levels and can induce chronic
inflammation in the neoplastic site, alternating the balance between proliferation and cell death.
Activated steroid hormone receptors induce transcription of genes that encode for proteins involved
in cell proliferation and activate another transduction pathway, inducing cell cycle progression
and cell migration. These important studies have allowed to develop therapies with selective
modulators of estrogen receptors (SERMs), able to block their proliferative and pro-tumorigenic
action. Of fundamental importance is also the role played by the microbiota in regulating
the metabolism of estrogens and their levels in the blood. There are microbial populations
that are able to promote the development of breast cancer, through the production of enzymes
responsible for the deconjugation of estrogens, the increase of these in the intestine, subsequent
circulation and migration to other locations, such as the udder. Other microbial populations are,
instead, able to synthesize estrogen compounds or mimic estrogenic action, and interfere with the
metabolism of drugs, affecting the outcome of therapies. The microbial composition of the intestine
and hormonal metabolism depend largely on eating habits; the consumption of fats and proteins
favours the increase of estrogen in the blood, unlike a diet rich in fiber. Therefore, in-depth
knowledge of the microbiota present in the intestine-breast axis could, in the future, encourage
the development of new diagnostic and therapeutic approaches to breast cancers.
A Kind of Electro-hydraulic Servo System Cooperative Control Simulation:
An Experimental Research
Authors: Gao Bingwei , Shen Wei , Dai Ye , Wang Wei
Published: April 2022

Background:

The single position control or force control of the electro-hydraulic servo
system has long been unable to meet the actual needs of production and life. To achieve a good control
effect and solve various problems in real life, people no longer only consider a single position
control or force control.

Objective:

The proposed method provides technical support for multi-objective collaborative control
of the electro-hydraulic servo system, completes the requirements of multitasking operation, improves
the positioning accuracy and response velocity of the electro-hydraulic servo system, and
realizes the synergy between the position and force.

Methods:

A control method of the outer loop control of force as feedforward compensation is
adopted to realize the coordinated control of force and position based on position control. The position
control part adopts the PID control algorithm to ensure real-time response accuracy and positioning
accuracy. The outer force loop uses an adaptive fuzzy neural network control algorithm to
reduce vibration and shock caused by system instability and nonlinear factors during the force control
process.

Results:

The control effect of the designed position/force collaborative controller is verified by simulation
and experiment. It can effectively reduce the vibration and impact caused by the contact
force during the working process of the system, at the same time greatly improving the accuracy of
position control and improving the stability of the system.

Conclusion::

The designed force/position collaborative control system has a good overall control
effect.
importance of understanding the application of marketing strategy for household MSME products on social media networks
Authors: Rachmawati Erny , Juminawati Sri , Akbar Ilham , Bahri Khoirun Nisa , Cakranegara Pandu Adi
Published: April 2022

This literature review aims to gain an in-depth understanding of many practical applications as a strategy to increase the marketing of small household business products, mainly social media networking applications. We think that in this era of increasingly networking, there is no mistaking that even small businesses are still integrated into the social networking system to increase marketing through various social media platforms. This study uses secondary data from scientific findings from some publications, both books, and scientific journals, especially in the marketing business. We have made research efforts to get the essence of understanding that can answer the problem of studying digital-based marketing literacy, especially this social media. Our strategy for getting the gist of the answer is through data analysis, which we believe is under a phenomenological approach, which starts with coding data analysis, then evaluates the data sharply, and we also interpret it so that we will be able to take the findings as conclusions that can answer the problem validly and impressive.
IMPLEMENTASI PROGRAM LAYANAN MUTASI SISWA SD DAN SMP DALAM PELAYANAN TERPADU SATU PINTU DI DINAS PENDIDIKAN PEMUDA DAN OLAHRAGA KOTA YOGYAKARTA
Authors: Septyaningsih Rimawati
Published: April 2022

This study aims to describe the implementation as well as the supporting and inhibiting factors of the transfer service program for elementary and junior high school students in PTSP at Disdikpora Yogyakarta City. The type of research used is descriptive with a qualitative approach. The results obtained are: (1) Implementation of the student transfer service program at the Disdikpora Yogyakarta City: a) The standard of mutation service is the value of students and the availability of class formations at the target school and the target is the community who wants to apply for a student transfer application. b) Resources in the form of 4 implementing officers from the Junior High School Development Division and Elementary School Development staff and adequate facilities. c) The characteristics of the organization are nimble and able to work well together. d) Relationships between organizations run with communication and coordination during service delivery. e) Environmental conditions are mutually supportive. f) Disposition is reflected in the capability of the executing agent. (2) The supporting factors are complete facilities, adequate human resources, and easy and clear administrative processes. The inhibiting factors a) Officers who are still double jobs so they cannot focus on student transfer services. b) Implementation of mutation services that cannot be carried out fully online. c) The file processing flow is still quite time consuming because of the manual numbering system. d) Not updating the field header for the files that enter the system. Keywords: Implementation, Student Mutation, Disdikpora Yogyakarta City
ANALISIS TREN ANGKA PUTUS SEKOLAH PADA PENDIDIKAN DASAR DI KABUPATEN BANTUL
Authors: Widyastuti Nur Aini
Published: April 2022

The purpose of this study are: to describe the tren of children’s dropping out rates from primary education, describe the factors that influence the change in the tren line of children dropping out of school in primary education in Bantul Regency, and describes policies and follow-up actions taken by the government to reduce dropout rates in Bantul Regency. This research is a descriptive quantitative research. The data was obtained from the Dikpora Bantul and analyzed with the least squares trend. The results of this study are: 1. At elementary level (SD/MI) in Bantul Regency, there is an increasing tren and has not reached 0%. At junior high level (SMP/MTs), there is a decreasing tren and has been reached 0%. 2. The results of tren analysis are influenced by internal and external factors that cause children to drop out of school; 3. Policy in the Elementary School sector, namely to activate compulsory education programs, social assistance, and inclusive schools. Follow-up in the SD sector by increasing public awareness, collaboration with various cross-agency. The SMP sector carries out a policy of completing the 9-year compulsory education program, simultaneous assistance, and tracing to the village level. Follow-up in the field of SMP by increasing Minimum Service Standards, maximizing support capacity, and discussing with Commission D. Keywords: Trens, Dropout Rate, Primary Education, Bantul Regency
Advocacy of The Ombudsman Institute for The Special Region of Yogyakarta in Completing The Complaints of Educational Problems in The Special Region of Yogyakarta
Authors: Astuti Titin Widhi
Published: April 2022

This study aims to describe the Advocacy of the Ombudsman Institute for the Special Region of Yogyakarta in completing the complaints of education problems in the Special Region of Yogyakarta. This research is a descriptive study with a qualitative approach. Data validity uses triangulation of sources, techniques, and time. Data analysis techniques include data collection, data condensation, data presentation, and conclusion drawings. Research Results: (1) Complaint of Education Problems in DIY Ombudsman Institutions Mapped into a Regular Complaint (Governance of Education and School Management) and Temporary (PPDB), (2) Stages of Advocacy for DIY Ombudsman Institutions, namely the Stage of Preparation (Consultation and Clarification), Implementation Stage (Coordination, investigation, mediation), and stages of assessment (monitoring). Advocacy of DIY Ombudsman Institutions specifically for education, namely educational complaints posts. (3) Supporting factors, namely the existence of pic every education office, complete documents, cooperative attitudes, and monitoring. Inhibiting factors, namely the lack of human resources, community concerns over the impact of the report, the school's violation of the definition of donations and levies, the final product recommendations as input, and the wrong perception of the public.
IMPLEMENTASI PROGRAM EDUCATION FOR SUSTAINABLE DEVELOPMENT DI SMA TUMBUH
Authors: Primasti Shelma Ghusa
Published: April 2022

Penelitian ini bertujuan menganalisis dan mendeskripsikan implementasi program Education for Sustainable Development (ESD serta faktor pendukung dan penghambatnya di SMA Tumbuh.   Jenis penelitian ini studi kasus dengan pendekatan kualitatif. Partisipan penelitian adalah kepala sekolah, koordinator kurikulum, guru permakultur, seni rupa, pendidikan pangan, Person in Charge (PIC) program magang dan mangrove planting, peserta didik SMA Tumbuh. Teknik pengumpulan data dengan observasi, wawancara, dokumentasi. Teknik analisis data dengan kondensasi data, penyajian data, penarikan kesimpulan. Uji keabsahan data dengan triangulasi teknik dan sumber. Hasil penelitian: ESD di SMA Tumbuh terintegrasi dalam mata pelajaran dan kegiatan. Implementasi program: komunikasi melalui sosialisasi terintegrasi dalam kegiatan pembelajaran, sumber daya manusia telah kompeten, perlu sumber daya manusia yang sesuai bidang keilmuan untuk permakultur, sumber daya anggaran dan fasilitas tersedia dan memadai, untuk permakultur masih perlu dipenuhi, disposisi program mendapatkan respon positif seluruh warga sekolah, struktur birokrasi melekat pada struktur organisasi sekolah. Faktor pendukung: dukungan berbagai pihak, koordinasi dan kolaborasi yang baik, sumber daya anggaran dan fasilitas, sekolah lebih menghargai peserta didik. Faktor penghambat: kondisi pandemi, sumber daya manusia untuk ESD lingkungan hidup belum sesuai bidang keilmuan, fasilitas mapel permakultur belum lengkap, hambatan cuaca, supervisor program magang belum secara penuh mengawasi siswa.
Implementasi Kebijakan Sekolah Adiwiyata di SMP Negeri 15 Purworejo
Authors: Priantari Ruci Anggraeni
Published: April 2022

Penelitian ini bertujuan mendeskripsikan wujud implementasi kebijakan sekolah adiwiyata di SMP Negeri 15 Purworejo serta mengidentifikasi proses implementasi kebijakan sekolah adiwiyata di SMP Negeri 15 Purworejo. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Subjek penelitian adalah Kepala Sekolah, Tim Adiwiyata, Guru, Karyawan, dan Siswa. Teknik pengumpulan data dengan metode observasi, wawancara, dan dokumentasi. Teknik analisis data dengan kondensasi data, penyajian data, dan verifikasi data. Uji keabsahan data dengan triangulasi sumber dan teknik. Hasil penelitian menunjukkan bahwa: 1) Proses Implementasi Kebijakan Sekolah Adiwiyata, dilihat dari beberapa aspek: (a) Komunikasi, melalui sosialisasi secara langsung dan melalui slogan atau pamflet. (b) Sumber daya manusia dan finansial cukup memadai untuk pelaksanaan kegiatan adiwiyata. (c) Disposisi, kebijakan sekolah adiwiyata mendapat respon dan dukungan yang baik dari berbagai pihak. (d) Struktur birokrasi, hubungan kerja sama dengan pemerintah setempat dan masyarakat berjalan dengan baik. 2) Wujud Implementasi Kebijakan Sekolah Adiwiyata terdapat beberapa aspek: a) Kebijakan Berwawasan Lingkungan, terintegrasi dengan visi misi tujuan sekolah. b) Pengembangan Kurikulum, memuat tentang pendidikan lingkungan yang disisipkan dalam setiap mata pelajaran. c) Kegiatan Partisipatif, kegiatan mendukung kebijakan adiwiyata antara lain; pengolahan pupuk kompos, aksi bersih pantai, pemeliharaan tanaman, bakti sosial, dan bersih lingkungan sekolah. d) Pengelolaan sarana pendukung sekolah, memanfaatkan sumber daya alam yang ada di lingkungan sekolah.
IMPLEMENTASI KEBIJAKAN PENDIDIKAN KARAKTER DI SMK NEGERI 2 DEPOK SLEMAN
Authors: Pratiwi Faridhatun Anisa
Published: April 2022

Abstrak Penelitian ini bertujuan untuk mendeskripsikan tentang perumusan kebijakan pendidikan karakter di SMK N 2 Depok, pelaksanaan kebijakan pendidikan karakter, serta faktor pendukung dan penghambatnya. Penelitian ini merupakan penelitian deskriptitif kualitatif, dengan metode wawancara, observasi, dan studi dokumen. Hasil penelitian ini yaitu: 1) Perumusan kebijakan pendidikan karakter di SMK N 2 Depok dilakukan dengan tahap diskusi, dituangkan ke dalam program sekolah, dan sosialisasi yang sesuai dengan teori transaktif; 2) Kebijakan pendidikan karakter di SMK N 2 Depok diintegrasikan ke dalam kegiatan pengembangan diri dan ekstrakurikuler; 3) Faktor pendukung implementasi kebijakan pendidikan karakter di SMK N 2 Depok yaitu tersedianya sarana prasarana. Sedangkan faktor penghambatnya adalah keterbatasan waktu pelaksanaan program pendidikan karakter. Kata Kunci: kebijakan pendidikan karakter, implementasi kebijakan pendidikan karakter, faktor pendukung dan penghambat pendidikan karakter Abstracs This study aims to describe the formulation of character education policies at Depok N 2 Vocational School, the implementation of character education policies, as well as supporting factors and barriers. This research is a qualitative descriptive research, with the method of interviews, observation, and document study. The results of this study are: 1) The formulation of character education policies at Depok N 2 Vocational High School is carried out with the discussion phase, poured into school programs, and socialization in accordance with the transactive theory; 2) Policy on character education at Depok N 2 Vocational School is integrated into self-development and extracurricular activities; 3) Supporting factors for the implementation of character education policies at Depok N 2 Vocational School, namely the availability of infrastructure. While the inhibiting factor is the limited time for implementing a character education program. Keywords: character education policies, implementation of character education policies, supporting factors and barriers to character education
IMPLEMENTASI PROGRAM JAMINAN PENDIDIKAN DAERAH (JPD) DI SMP NEGERI 10 YOGYAKARTA
Authors: Latifah Luluk
Published: April 2022

Abstrak Penelitian ini bertujuan untuk mendeskripsikan implementasi program jaminan pendidikan daerah (JPD) di SMP Negeri 10 Yogyakarta. Penelitian ini merupakan penelitian kualitatif deskriptif. Subjek dalam penelitian ini yaitu kepala sekolah, guru pengelola JPD dan siswa di SMP Negeri 10 Yogyakarta. Teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Teknik analisis data menggunakan model Miles, Huberman, dan Saldana yaitu dengan langkah kondensasi data, penyajian data, dan menarik kesimpulan. Uji keabsahan data pada penelitian ini menggunakan triangulasi sumber dan teknik.Hasil penelitian menunjukkan bahwa : (1) Dalam implementasi program jaminan pendidikan daerah di SMP Negeri 10 Yogyakarta terdapat mekanisme diantaranya : mengumpulkan data siswa yang mempunyai identitas Kartu Menuju Sejahtera (KMS), merekap data, dan mengumpulkan data ke dinas pendidikan. (2) Implementasi program jaminan pendidikan daerah di SMP Negeri 10 Yogyakarta terdapat pelaksanaan yang meliputi empat aspek yang diantaranya : komunikasi, sumberdaya, disposisi, dan struktur birokrasi. (3) Pelaksanaan program JPD didukung dengan komunikasi melalui sosialisasi dengan orangtua siswa, sumberdaya manusia yang didukung dengan fasilitas, anggaran, kewenangan, serta disposisi kinerja yang maksimal, struktur birokrasi yang sesuai dengan petunjuk teknis pelaksanaan program JPD dan kerja sama antar sekolah, dinas pendidikan dan orangtua. Kata Kunci : Implementasi dan Jaminan Pendidikan Daerah (JPD) Abstract This study aims to describe the implementation regional education guarantee in SMP Negeri 10 Yogyakarta.This research is a descriptive qualitative. Subjects in this study were students, teacher (school managers in the JPD) and headmaster SMP Negeri 10 Yogyakarta. Data were collected through interviews, observation, and documentation. Data analysis techniques used is qualitative descriptive from Miles, Huberman, and Saldana model (data condensation, data display, and verifying conclusions). Validity measured in this research using triangulation. The result of the research show that : (1) The mechanism for implementation regional education guarantee (JPD) in SMP Negeri 10 Yogyakarta : collecting data from students who have  KMS cards, recapitulating data, and collecting data to the education office. (2) Implementation regional education guarantee (JPD) in SMP Negeri 10 Yogyakarta covering four aspects of communication, resources, disposition, and bureaucratic structure. (3) The implementation of the JPD has been supported with communication through socialization with parents, human resources, facilities, budget, authority, and maximum performance, in accordance with technical guidelines implementation of JPD cooperation between school, education office and parents. Keywords : Implementation and regional education guarantee (JPD)