bluuebunny/crossref_metadata_2025 huggingface dataset:
Female Sex and Living in a Large City Moderate the Relationships between Nursing Students’ Stress Level, Perception of Their Studies, and Intention to Practice Professionally: A Cross-Sectional Study
Authors: Pawlak Natalia Dominika , Serafin Lena , Czarkowska-Pączek Bożena
Published: May 2022

One way to increase nursing retention is to expand the number of nursing education programs; however, a more cost-effective initial step would be to ensure that each graduate will start a professional career. Nursing studies expose students to prolonged and uncontrolled stress that negatively affects their professional identity and health. Two hundred and fifty-four nursing students participated in this study. The data were obtained using the Perceived Stress Scale (PSS-10), a proprietary questionnaire on the students’ perception of their study, intention to practice in the future, and other metrics. Among our sample, a dozen students were unsure that they would enter the nursing profession. Stress levels in women were higher than in men. Respondents indicated that they were afraid of the return of the pandemic. This analysis was significant among people living in large cities. Based on our findings, five themes should be prioritised: favourable study environment and adequate competencies (including implementation of stress management techniques, especially among women and students living and studying in large cities), appropriate working hours, quality of practical classes, and quality of personal protective equipment.
Social Determinants of Health and Distance Learning in Italy in the Era of the SARS-CoV-2 Pandemic
Authors: Dondi Arianna , Lenzi Jacopo , Candela Egidio , Sureshkumar Sugitha , Morigi Francesca , Biagi Carlotta , Lanari Marcello
Published: May 2022

Objectives: To investigate the experiences by distance learning (DL) method during the first wave of the SARS-CoV-2 pandemic in Italy, and to search for correlations with purported experiences and respective levels of social determinants of health (SDH). Study design and methods: Cross-sectional online survey, investigating various SDH and parents’ attitude towards DL, proposed 6 months after the beginning of the pandemic to a sample population of parents with school-aged children throughout Italy. Results: A total of 3791 questionnaires were analyzed. Non-Italian parents complained more frequently of difficulties in providing support to their children in DL due to poor digital skills (p = 0.01), lack of good-quality digital equipment (p = 0.01), problems with the Italian language (p < 0.001), and a lower level of education (p < 0.001). When parents lived apart, greater difficulties in concentration in children using DL (p = 0.05) and a lower parental capacity to support DL (p = 0.002) were reported. Adequate digital structures appeared related to living in owned compared to rented property, higher levels of parental education, and better familial financial situations. Conclusions: Students from families with financial difficulties and low levels of parental education, or even those living in houses for rent or having separated parents, may be disadvantaged in an educational context since the introduction of DL.
Laboratory Studies on the Rheotaxis of Fish under Different Attraction Flow Conditions
Authors: Tang Nanbo , Wang Xiaogang , Li Yun , Zhu Long , Tang Zhushuan , Li Hongze , He Feifei , Huang Yongzeng , Zhang Zhengxian
Published: May 2022

The damming of the river changes the structure of the original river ecosystem, and although fish passage plays an important role in maintaining the connectivity of the river ecosystem, the fish have difficulty finding the fish passage entrance during the upstream process. This paper studied the rheotaxis of fish under three different water flow conditions experimentally through recirculating water tanks. To better understand the response of Crucian carp (Carassius auratus) to water flow stimulation, the representative swimming trajectory, sensing success rate, attraction success rate, reaction time, and attraction time of the fish were analyzed by using a video monitoring system. The experimental results showed that fish responded differently to single-peak and lateral bimodal outflow conditions: (1) the single-peak outflow condition had a much better attraction effect than the lateral bimodal outflow condition, both in terms of sensing success rate and attraction success rate; (2) the fish swam mainly in the middle area of the lateral bimodal outflow condition, while the fish swam more evenly in the single-peak outflow condition. Therefore, setting the attraction current at the right time and near the entrance of the fish passage may help to improve the effect of fish attraction.
Nutrient Intake and Dietary Acid Load of Special Diets in the NHANES: A Descriptive Analysis (2009–2018)
Authors: Storz Maximilian Andreas , Müller Alexander , Ronco Alvaro Luis
Published: May 2022

Western diets are characterized by a high dietary acid load (DAL), which has been associated with adverse clinical outcomes, including type-2-diabetes and metabolic syndrome. Effective dietary strategies to lower DAL are urgently warranted. Plant-based diets (PBD), including vegetarian and vegan diets, are an effective measure to reduce DAL. Notably, not every individual wishes to adopt a PBD. Instead, many people rely on special diets promising comparable health benefits. The effects of those diets on DAL have rarely been investigated. Using data from the National Health and Nutrition Examination Surveys, we aimed to quantify DAL and nutrient intake in the most popular special diets in the United States, including weight-loss, low fat, low salt, low sugar, and diabetic diets. Our analysis included 3552 individuals on a special diet. The most popular diets were the weight-loss diet (n = 1886 individuals) and the diabetic diet (n = 728). Energy intake was below 2000 kcal/d for all diets; however, there were no statistically significant intergroup differences. DAL scores were positive for all special diets (>9 mEq/d), suggesting acidifying properties. Acid load scores of special diets did not differ significantly and were comparable to a standard Western diet. None of the examined diets was associated with alkaline properties.
Evaluation of Potential for Nature-Based Recreation in the Qinghai-Tibet Plateau: A Spatial-Temporal Perspective
Authors: Lu Yayan , Han Fang , Liu Qun , Wang Zhaoguo , Wang Tian , Yang Zhaoping
Published: May 2022

Nature-based recreation (NBR) is an important cultural ecosystem service providing human well-being from natural environments. As the most concentrated and high-quality wilderness in China, the Qinghai-Tibet Plateau (QTP) has unique advantages for NBR. In this study, we designed an integrated nature-based recreation potential index (INRPI) based on four aspects: nature-based recreation resources, landscape attractiveness, recreation comfort and opportunity, and recreation reception ability. A combination of the analytic hierarchy process (AHP) and entropy evaluation method was adopted to assess the NBR potential in the QTP from 2000 to 2020. The research shows that: (i) The INRPI for the QTP decreases gradually from southeast to northwest and increases slightly from 2000 to 2020. (ii) The INRPI displays a pronounced difference on either side of the Qilian-Gyirong line. The areas with very high and high potentials mainly distributed in the southeast of the line, while areas with very low and low potentials distributed in the northwest. (iii) The construction of protected areas effectively improves NBR potential. Areas of INRPI at diverse levels within protected areas obviously increased in 2020. (iv) Increasing altitude has a notable effect on INRPI, and 3000 m is a critical dividing line for the NBR in the QTP. These findings can contribute to decision-makers in guiding rational use and spatial planning of natural land and promoting sustainable recreational development.
Public Expenditure and Green Total Factor Productivity: Evidence from Chinese Prefecture-Level Cities
Authors: Zhao Weixiang , Xu Yankun
Published: May 2022

Whilst effective public expenditure policies are essential for transforming the traditional factor-driven economy into a green and innovation-driven economy, the impacts of public expenditure’s size and composition on green economic development have not been comprehensively investigated. This paper attempts to fill this research gap. Based on the data of Chinese prefecture-level cities from 2010 to 2018, we first measure green total factor productivity (GTFP), the proxy variable for green development, and briefly analyze its spatial-temporal trends. Then, using the dynamic panel models, dynamic panel mediation models, and dynamic panel threshold models, we evaluate how public expenditure affects GTFP. The main findings are fourfold: (1) there is a significant inverted U-shaped relationship between the expenditure size and GTFP. (2) The expansion of social expenditures and science and technology (S&T) and environmental protection expenditures play an important role in stimulating green growth, while economic expenditures and administrative expenditures have adverse effects. (3) Public expenditure mainly promotes green development through four channels: human capital accumulation, technological innovation, environmental quality improvement, and labor productivity increase. (4) The expenditure composition influences the turning point of the inverted U-shaped relationship. Based on these findings, we propose some targeted policy suggestions to promote green development.
Oxygen Uptake Measurements and Rate of Perceived Exertion during a Marathon
Authors: Billat Véronique , Poinsard Luc , Palacin Florent , Pycke Jean Renaud , Maron Michael
Published: May 2022

Although the marathon race has been democratized, it remains complex due to the famous “hitting the wall” phenomenon after the 25th km. To characterize this “wall” from a physiological and Rate of Perceived Exertion (RPE) perspective in recreational marathon runners, we report first continuous breath-by-breath gas exchange measurements during an actual marathon race. In order to test the hypothesis that RPE could be a candidate for controlling the marathon pace, this study examined the relationship between RPE and the physiological variables time course throughout a marathon. Only the respiratory frequency and heart rate increased progressively during the race in all the runners, while the oxygen uptake and ventilatory rate followed different kinetics according the individuals. However, the indexation of the physiological parameters and speed by RPE showed the same decreased tendency for all the runners. In conclusion, these results suggest that running a marathon must be self-paced with the RPE.
The Relationship between Exposure to Airborne Particulate and DNA Adducts in Blood Cells in an Urban Population of Subjects with an Unhealthy Body Mass Index
Authors: Pulliero Alessandra , Iodice Simona , Pesatori Angela Cecilia , Vigna Luisella , Khalid Zumama , Bollati Valentina , Izzotti Alberto
Published: May 2022

Bulky DNA adducts are a combined sign of aromatic chemical exposure, as well as an individual’s ability to metabolically activate carcinogens and repair DNA damage. The present study aims to investigate the association between PM exposure and DNA adducts in blood cells, in a population of 196 adults with an unhealthy BMI (≥25). For each subject, a DNA sample was obtained for quantification of DNA adducts by sensitive32P post-labelling methods. Individual PM10 exposure was derived from daily mean concentrations measured by single monitors in the study area and then assigned to each subject by calculating the mean of the 30 days (short-term exposure), and of the 365 (long-term exposure) preceding enrolment. Multivariable linear regression models were used to study the association between PM10 and DNA adducts. The majority of analysed samples had bulky DNA adducts, with an average value of 3.7 ± 1.6 (mean ± SD). Overall, the findings of the linear univariate and multiple linear regression showed an inverse association between long-term PM10 exposure and adduct levels; this unexpected result might be since the population consists of subjects with an unhealthy BMI, which might show an atypical reaction to airborne urban pollutants; a hermetic response which happens when small amounts of pollutants are present. Pollutants can linger for a long time in the adipose tissue of obese persons, contributing to an increase in oxidative DNA damage, inflammation, and thrombosis when exposure is sustained.
Management of Breast Abscess during Breastfeeding
Authors: Pileri Paola , Sartani Alessandra , Mazzocco Martina Ilaria , Giani Sofia , Rimoldi Sara , Pietropaolo Gaia , Pertusati Anna , Vella Adriana , Bazzi Luca , Cetin Irene
Published: May 2022

(1) Background: Breast abscess (BA) is a condition leading in the majority of cases to breastfeeding interruption. Abscesses are commonly treated with antibiotics, needle aspiration or incision and drainage (I&D), but there is still no consensus on the optimal treatment. Since there are no well-defined clinical guidelines for abscess management, we conducted a retrospective, observational study with the aim of assessing ultrasound (US)-guided management of BA without surgery, regardless of the BA size. The secondary objective was the microbiologic characterization and, in particular, the S. aureus methicillin resistance identification. (2) Methods: our population included 64 breastfeeding mothers with diagnosis of BA. For every patient, data about maternal, perinatal and breastfeeding features were collected. All patients underwent office US scans and 40 out of 64 required a more detailed breast diagnostic ultrasound performed by a radiologist. In all cases, samples of milk or abscess material were microbiologically tested. All patients received oral antibiotic treatment. We performed needle aspiration, when feasible, even on abscesses greater than 5 cm. (3) Results: most of the women developed BA during the first 100 days (68.8% during the first 60 days) after delivery and 13 needed hospitalization. Four abscesses were bilateral and 16 had a US major diameter greater than 5 cm. All patients were treated with antibiotic therapy according to our clinical protocol and 71.9% (46/64) underwent fine needle aspiration. None of them required I&D. The average duration of breastfeeding was 5 months (IR 2; 9.5) and 40.6% of women with BA continued to breastfeed for more than 6 months. Only 21 mothers interrupted breastfeeding before 3 months. (4) Conclusions: our observational data suggest, regardless of the size and the clinical features of the BA, a conservative approach with antibiotic therapy targeted at the Methicillin-Resistant Staphilococcus aureus (MRSA) identified and needle aspiration, if feasible. In our experience, treatment with needle aspiration is a cost- effective method. Unlike drainage, it is an outpatient procedure, easily repeatable, with no cosmetic damage. In addition, it has lower risk of recurrences since, differently from surgical incision, it does not cause interruption of the ducts. Moreover, needle aspiration is less painful, does not require the separation of the mother-child dyad and allows for a quicker, if not immediate, return to breastfeeding.
Regional Disparities in Caries Experience and Associating Factors of Ghanaian Children Aged 3 to 13 Years in Urban Accra and Rural Kpando
Authors: Peters Anna , Brandt Karolin , Wienke Andreas , Schaller Hans-Günter
Published: May 2022

(1) The objective of this socio-epidemiologic cross-sectional study was to investigate caries burdens in Ghanaian children aged 3 to 13 years. The main focus was the analysis of urban–rural disparities and associating socio-demographic and behavioural factors. (2) Standardized caries examination with documentation of decayed, missing, filled deciduous (dmft) and permanent teeth (DMFT) was conducted in 11 school facilities according to WHO guidelines. A parental questionnaire gathered data considering associating factors. Descriptive statistics were used to evaluate their influence on caries prevalence and experience using mean dmft+DMFT, Significant Caries Index (SiC), and Specific Affected Caries Index (SaC). (3) In total, 313 study participants were included (mean age 7.7 ± 3.8 years; 156 urban, 157 rural). The urban region showed slightly higher caries prevalence (40.4% vs. 38.9%). The rural region had higher caries experience in mean dmft+DMFT (1.22 ± 2.26 vs. 0.96 ± 1.58), SiC (3.52 ± 2.73 vs. 2.65 ± 1.71), and SaC (3.15 ± 2.68 vs. 2.37 ± 1.68). Lower education and occupation level of parents and rural residence were associated to higher caries values. Sugary diet showed an inverse relation with caries prevalence and oral hygiene practices supported the generally known etiologic correlation. (4) This study highlights the importance of targeting children vulnerable to caries due to social inequality with adequate preventive means. The implementation of regular dental screening and education, e.g. in schools, may be helpful.
The Effect of Urban Shrinkage on Carbon Dioxide Emissions Efficiency in Northeast China
Authors: Zeng Tianyi , Jin Hong , Geng Zhifei , Kang Zihang , Zhang Zichen
Published: May 2022

Climate change caused by CO2 emissions is a controversial topic in today’s society; improving CO2 emission efficiency (CEE) is an important way to reduce carbon emissions. While studies have often focused on areas with high carbon and large economies, the areas with persistent contraction have been neglected. These regions do not have high carbon emissions, but are facing a continuous decline in energy efficiency; therefore, it is of great relevance to explore the impact and mechanisms of CO2 emission efficiency in shrinking areas or shrinking cities. This paper uses a super-efficiency slacks-based measure (SBM) model to measure the CO2 emission efficiency and potential CO2 emission reduction (PCR) of 33 prefecture-level cities in northeast China from 2006 to 2019. For the first time, a Tobit model is used to analyze the factors influencing CEE, using the level of urban shrinkage as the core variable, with socio-economic indicators and urban construction indicators as control variables, while the mediating effect model is applied to identify the transmission mechanism of urban shrinkage. The results show that the CEE index of cities in northeast China is decreasing by 1.75% per annum. For every 1% increase in urban shrinkage, CEE decreased by approximately 2.1458%, with urban shrinkage, industrial structure, and expansion intensity index (EII) being the main factors influencing CEE. At the same time, urban shrinkage has a further dampening effect on CEE by reducing research and development expenditure (R&D) and urban compactness (COMP), with each 1% increase in urban shrinkage reducing R&D and COMP by approximately 0.534% and 1.233%, respectively. This can be improved by making full use of the available built-up space, increasing urban density, and promoting investment in research.
Mechanical Properties of 3D Printed Orthodontic Retainers
Authors: Firlej Marcel , Zaborowicz Katarzyna , Zaborowicz Maciej , Firlej Ewa , Domagała Ivo , Pieniak Daniel , Igielska-Kalwat Joanna , Dmowski Artur , Biedziak Barbara
Published: May 2022

Orthodontic retention is the final important stage of orthodontic treatment, the aim of which is to consolidate the functional and aesthetic position of teeth. Among adults, fixed retainers made of different types of wires are the most common. The aim of this study was to analyse the mechanical properties of a new generation of fixed orthodontic retainers—printed by 3D printers. Materials and Methods: The study was conducted using samples made of Nextdent MFH C&B N1 resin in the form of cuboid bars with nominal dimensions of width b = 3 mm, thickness d = 0.8 mm; 1 mm; 1.2 mm, length l = 30 mm for each type. The influence of the thickness of the retainers on their strength under loaded conditions was evaluated. Flexural strength, elastic properties, deflection, and creep were compared. The samples were aged in an artificial saliva bath at 37 ± 1 °C during the strength tests. Results: It was shown that differences in the thickness of the samples affected their elastic and strength properties. The highest average flexural modulus, the highest deflection, creep, and strength was characteristic of the samples with the highest thickness (1.2 mm). Samples with an average thickness of 1 mm had the lowest modulus of elasticity. Conclusions: The mechanical properties of 3D printed retainers show that they can be an alternative to metal retainers and the procedure of making new retainers, especially when patients have aesthetic requirements or allergies to metals.
Problematic Smartphone Use and Its Associations with Sexual Minority Stressors, Gender Nonconformity, and Mental Health Problems among Young Adult Lesbian, Gay, and Bisexual Individuals in Taiwan
Authors: Huang Mei-Feng , Chang Yu-Ping , Lu Wei-Hsin , Yen Cheng-Fang
Published: May 2022

Smartphones are a necessity for many people; however, problematic smartphone use (PSU) may negatively influence people’s mental health. Using multivariate linear regression analysis, the study examined the associations of sexual minority stressors [namely perceived sexual stigma from family members, sexual orientation microaggressions (SOMs), and internalized sexual stigma] and gender nonconformity with PSU severity as well as the associations of PSU with depression and anxiety in young adult lesbian, gay, and bisexual (LGB) individuals. This cross-sectional survey study recruited 1000 young adult LGB individuals (500 men and 500 women). PSU severity was assessed using the Smartphone Addiction Inventory. The experiences of perceived sexual stigma from family members, SOMs, and internalized sexual stigma and the levels of gender nonconformity, depression, and anxiety were assessed. The results indicated that perceived sexual stigma from family members, SOMs, internalized sexual stigma in the dimensions of social discomfort and identity and gender nonconformity were significantly associated with PSU severity in LGB individuals. Moreover, PSU was significantly associated with depression and anxiety in LGB individuals. The findings highlight the significance of developing strategies for the prevention and early detection of PSU and sexual minority stress in LGB individuals.
The Combinations of Physical Activity, Screen Time, and Sleep, and Their Associations with Self-Reported Physical Fitness in Children and Adolescents
Authors: Chen Zhenhuai , Chi Guijun , Wang Lei , Chen Sitong , Yan Jin , Li Shihao
Published: May 2022

Much evidence has indicated that adherence to the 24 h movement guidelines (physical activity, screen time and sleep) is associated with physical health, while little is known about the adherence to the 24 h movement guidelines and self-reported physical fitness in adolescents. This study, therefore, aims to explore the association between the 24 h movement guidelines (in isolation or combination) and self-reported physical fitness in a sample of Chinese adolescents in an age range of 10–17. Methods: A convenient sample of 3807 children and adolescents from 12 schools was adopted in the present study. A questionnaire based on the Health Behaviour in School-aged Children was used to assess physical activity and screen time, and the Pittsburgh Sleep Scale was utilized to measure sleep duration. The International Fitness Scale was used to assess physical fitness in study participants. Ordinal logistic regression was performed to estimate the association between adherence to the 24 h movement guidelines and self-reported physical fitness. Results: Of all study participants, 0.9% of them met the 24 h movement guidelines, and meeting the guidelines was significantly associated with higher levels of self-reported physical fitness. The analysis for the association between specific combinations of 24 h movement guidelines and self-reported physical fitness underscored the importance of meeting the physical activity recommendations. Conclusion: Adherence to more recommendations contained in the 24 h movement guidelines was associated with higher self-reported physical fitness, especially cardiorespiratory fitness and muscular strength. Our study also stressed the importance of promoting moderate to vigorous physical activity in children and adolescents. Further works should focus on the association of a recommendation of adherence with other health indicators and replicate this study on larger samples among Chinese children and adolescents. Additionally, longitudinal or interventional studies that include more socio-demographic factors are needed to explore the association between 24 h movement guidelines and self-reported physical fitness, and the 24 h movement guidelines also should be promoted on a large scale in Chinese children and adolescents. Moreover, it is also needed to gain better insights into the directionality of the relationship between compliance with 24 h movement guidelines and self-reported physical fitness, as well as the mechanisms underlying the associations in Chinese children and adolescents.
A Guideline for Contextual Adaptation of Community-Based Health Interventions
Authors: Pardoel Zinzi E. , Reijneveld Sijmen A. , Postma Maarten J. , Lensink Robert , Koot Jaap A. R. , Swe Khin Hnin , Van Nguyen Manh , Pamungkasari Eti Poncorini , Tenkink Lotte , Vervoort Johanna P. M. , Landsman Johanna A.
Published: May 2022

In Southeast Asia, community-based health interventions (CBHIs) are often used to target non-communicable diseases (NCDs). CBHIs that are tailored to sociocultural aspects of health and well-being: local language, religion, customs, traditions, individual preferences, needs, values, and interests, may promote health more effectively than when no attention is paid to these aspects. In this study, we aimed to develop a guideline for the contextual adaption of CBHIs. We developed the guideline in two stages: first, a checklist for contextual and cultural adaptation; and second, a guideline for adaptation. We performed participatory action research, and used the ‘Appraisal of Guidelines for Research & Evaluation (AGREE) II’ tool as methodological basis to develop the guideline. We conducted a narrative literature review, using a conceptual framework based on the six dimensions of ‘Positive Health’ and its determining contexts to theoretically underpin a checklist. we pilot tested a draft version of the guideline and included a total of 29 stakeholders in five informal meetings, two stakeholder meetings, and an expert review meeting. This yielded a guideline, addressing three phases: the preparation phase, the assessment phase, and the adoption phase, with integrated checklists comprising 34 cultural and contextual aspects for the adaption of CBHIs based on general health directives or health models. The guideline provides insight into how CBHIs can be tailored to the health perspectives of community members, and into the context in which the intervention is implemented. This tool can help to effect behavioral change, and improve the prevention and management of NCDs.
Baby Food and Oral Health: Knowledge of the Existing Interaction
Authors: Fioravanti Miriam , Di Giorgio Gianni , Amato Roberta , Bossù Maurizio , Luzzi Valeria , Ierardo Gaetano , Polimeni Antonella , Vozza Iole
Published: May 2022

Background: The purpose of this study is to verify parents’ knowledge of child nutrition and their awareness of the interaction between unhealthy sugars in their child’s diet and caries formation. Methods: a questionnaire was proposed using Instagram to analyze type of breastfeeding; type of weaning and diet; home oral hygiene maneuvers; bad habits (use of pacifiers, bottles, and sugary substances); knowledge on the usefulness of fluoride; and first dental visit. A total of 200 parents from different regions of Italy with children aged 2 months to 6 years were contacted. Results showed that 66% parents preferred breastfeeding, while the remaining 34% chose artificial breastfeeding. Fifty percent (100 babies) started weaning at six months, 20% (40 babies) at the fifth month, 13.5% (27 babies) at the fourth month, and only 11.5% (23 babies) in a range from the seventh to ninth month of life. Oral hygiene practices were performed only by 25% of parents before eruption of the first tooth. After eruption of the first tooth, there is greater attention to home oral hygiene practices: 59% of parents carry out and teach their children daily home oral hygiene maneuvers. Conclusions: it is possible to raise awareness among parents and caregivers on the importance of food education.
Parent’s Health Locus of Control and Its Association with Parents and Infants Characteristics: An Observational Study
Authors: Morniroli Daniela , Sannino Patrizio , Rampini Serena , Bezze Elena Nicoletta , Milotta Eleonora , Poggetti Silvia , Marchisio Paola , Bosis Samantha , Plevani Laura , Mosca Fabio , Giannì Maria Lorella
Published: May 2022

The Parent Health Locus of Control (PHLOC) investigates the individual’s beliefs about the factors that govern their state of health and that of their children. The direct association between PHLOC and preventive health behaviours compliance has already been demonstrated in the literature. However, it is still unclear how socio-demographic variables affect the PHLOC. We investigated the Parent Health Locus of Control of parents of full-term and preterm infants and evaluated whether there were any correlations between PHLOC and socio-demographic characteristics of both parents and infants. A single-centre transverse observational study was conducted in the Neonatology Operating Unit IRCCS Ca ‘Granda Foundation Ospedale Maggiore Policlinico of Milan. A self-administered questionnaire of the PHLOC scale was distributed to a sample of 370 parents of 320 full-term and 52 preterm infants attending the follow-up service. Parents under the age of 36 and with a higher level of education (bachelor’s degree or above) believe less in the influence of the media on their child’s health. Parents of preterm and first-child infants recognize the greater influence of health care workers, while parents of newborns that have experience complications in their clinical course, believe more in the influence of fate (Chance Health Locus of Control) and God. Younger parents with a higher level of education may be more prone to healthy preventative behaviours. Preterm birth is positively associated with an increased trust in health care professionals. The experience of disease can increase a “Chance Health Locus of Control” and risky behaviours. Assessment of PHLOC helps identify categories of parents prone to risky health behaviours and offer targeted health education interventions.
Dental Caries and Oral Health Status of Psychoactive Substance Abusers
Authors: Bhavsar Rashmi , Shah Vandana , Ajith Namratha A. , Shah Kinjal , Al-amoudi Ahmed , Bahammam Hammam Ahmed , Bahammam Sarah Ahmed , Zidane Bassam , Albar Nassreen Hassan Mohammad , Bhandi Shilpa , Raj A. Thirumal , Patil Shankargouda
Published: May 2022

Substance-abuse disorders are universally associated with comorbid illness. Tobacco is a widely abused substance across the globe and presents a critical public health problem. The precise correlation between tobacco use and dental caries remains unclear. Thus, the present study aimed to evaluate the correlation between tobacco use and dental caries. Methodology: Based on selection criteria, a total of 270 (age 20–50 years) participants were included in the study, and were categorized as group A (n = 135), consisting of tobacco users, and group B (n = 135), comprising healthy controls (non-users). The Decayed, Missing, and Filled index (DMFT) was used to measure caries status. The Simplified Oral Hygiene index was used to evaluate oral health. Results: The tobacco group reported the use of cigarettes; smokeless tobacco in indigenous forms, such as gutka (areca nut, tobacco, and slaked lime), betel nut chewing; and a combination. Individuals with tobacco habits had a higher prevalence of dental caries (Mean DMFT 4.73 ± 4.32) compared to the non-habit group (Mean DMFT 3.17 ± 3.11 (p = 0.001). The Oral Hygiene index was significantly higher (indicating bad/poor oral hygiene) in tobacco abusers than those of non-users (p = 0.0001). Duration and frequency of tobacco use were correlated with the levels of moderate and severe caries (p = 0.001). Conclusion: Psychoactive substance abuse, such as smoking/smokeless tobacco consumption, is associated with higher prevalence of dental caries.
Key Stakeholder Priorities for the Review and Update of the Australian Guide to Diagnosis of Fetal Alcohol Spectrum Disorder: A Qualitative Descriptive Study
Authors: Hayes Nicole , Akison Lisa K. , Goldsbury Sarah , Hewlett Nicole , Elliott Elizabeth J. , Finlay-Jones Amy , Shanley Dianne C. , Bagley Kerryn , Crawford Andi , Till Haydn , Crichton Alison , Friend Rowena , Moritz Karen M. , Mutch Raewyn , Harrington Sophie , Webster Andrew , Reid Natasha
Published: May 2022

Since the 2016 release of the Australian Guide to the Diagnosis of Fetal Alcohol Spectrum Disorder (FASD), considerable progress has been made in the identification and diagnosis of the disorder. As part of a larger process to review and update the Guide, the aim of this study was to identify review priorities from a broad range of stakeholders involved in the assessment and diagnosis of FASD. Sixty-two stakeholders, including healthcare practitioners, researchers, other specialists, individuals with cultural expertise, lived experience and consumer representatives completed an online survey asking them to describe up to five priorities for the review of the Australian Guide to the Diagnosis of FASD. A total of 267 priorities were described. Content analysis of responses revealed priority areas relating to diagnostic criteria (n = 82, 30.7%), guideline content (n = 91, 34.1%), guideline dissemination (n = 15, 5.6%) and guideline implementation (n = 63, 23.6%). Other considerations included prevention and screening of FASD (n = 16, 6%). Engaging stakeholders in setting priorities will ensure the revised Australian Guide can be as relevant and meaningful as possible for the primary end-users and that it meets the needs of individuals with lived experience who will be most affected by the diagnosis.
Corporate Governance, Financial Innovation and Performance: Evidence from Taiwan’s Banking Industry
Authors: Wang Lie-Huey , Cao Xin-Yuan
Published: May 2022

This study explores the effect of corporate governance on financial innovation and the effect of financial innovation on performance in Taiwan’s banking industry from 2011 to 2019. The results find that the banks have higher shareholding of institutional investors, ratio of independent directors, attendance rate of directors, average education level of directors and more directors with a financial or accounting background, the greater innovative financial services offered by banks. After 2015, the impact of corporate governance on banks’ innovative financial services has increased. Moreover, the greater financial innovation services, the higher the bank profitability and value, especially after 2015. Finally, offering more innovative financial services can enhance the value of financial-holding subsidiary banks; by contrast, doing the same might negatively affect the profitability of nonfinancial-holding banks.
Continuous Monitoring of the Surface Water Area in the Yellow River Basin during 1986–2019 Using Available Landsat Imagery and the Google Earth Engine
Authors: Hu Qingfeng , Li Chongwei , Wang Zhihui , Liu Yang , Liu Wenkai
Published: May 2022

The Yellow River Basin (YRB) has been facing severe water shortages; hence, the long-term dynamic monitoring of its surface water area (SWA) is essential for the efficient utilization of its water resources and sustainable socioeconomic development. In order to detect the changing trajectory of the SWA of the YRB and its influencing factors, we used available Landsat images from 1986 through to 2019 and a water and vegetation indices-based method to analyze the spatial–temporal variability of four types of SWAs (permanent, seasonal, maximum and average extents), and their relationship with precipitation (Pre), temperature (Temp), leaf area index (LAI) and surface soil moisture (SM).The multi-year average permanent surface water area (SWA) and seasonal SWA accounted for 46.48% and 53.52% in the Yellow River Basin (YRB), respectively. The permanent and seasonal water bodies were dominantly distributed in the upper reaches, accounting for 70.22% and 48.79% of these types, respectively. The rate of increase of the permanent SWA was 49.82 km2/a, of which the lower reaches contributed the most (34.34%), and the rate of decrease of the seasonal SWA was 79.18 km2/a, of which the contribution of the source region was the highest (25.99%). The seasonal SWA only exhibited decreasing trends in 13 sub-basins, accounting for 15% of all of the sub-basins, which indicates that the decrease in the seasonal SWA was dominantly caused by the change in the SWA in the main river channel region. The conversions from seasonal water to non-water bodies, and from seasonal to permanent water bodies were the dominant trends from 1986 to 2019 in the YRB. The SWA was positively correlated with precipitation, and was negatively correlated with the temperature. Because the permanent and seasonal water bodies were dominantly distributed in the river channel region and sub-basins, respectively, the change in the permanent SWA was significantly affected by the regulation of the major reservoirs, whereas the change in the seasonal SWA was more closely related to climate change. The increase in the soil moisture was helpful in the formation of the permanent water bodies. The increased evapotranspiration induced by vegetation greening played a significant positive role in the SWA increase via the local cooling and humidifying effects, which offset the accelerated water surface evaporation caused by the atmospheric warming.
Bilayer Forming Phospholipids as Targets for Cancer Therapy
Authors: Stoica Celine , Ferreira Adilson Kleber , Hannan Kayleigh , Bakovic Marica
Published: May 2022

Phospholipids represent a crucial component for the structure of cell membranes. Phosphatidylcholine and phosphatidylethanolamine are two phospholipids that comprise the majority of cell membranes. De novo biosynthesis of phosphatidylcholine and phosphatidylethanolamine occurs via the Kennedy pathway, and perturbations in the regulation of this pathway are linked to a variety of human diseases, including cancer. Altered phosphatidylcholine and phosphatidylethanolamine membrane content, phospholipid metabolite levels, and fatty acid profiles are frequently identified as hallmarks of cancer development and progression. This review summarizes the research on how phospholipid metabolism changes over oncogenic transformation, and how phospholipid profiling can differentiate between human cancer and healthy tissues, with a focus on colorectal cancer, breast cancer, and non-small cell lung cancer. The potential for phospholipids to serve as biomarkers for diagnostics, or as anticancer therapy targets, is also discussed.
AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice—A Pilot Study
Authors: Schepelmann Martin , Kupper Nadja , Gushchina Valeriya , Mesteri Ildiko , Manhardt Teresa , Moritsch Stefan , Müller Christian , Piatek Karina , Salzmann Martina , Vlasaty Andrea , Eferl Robert , Kallay Enikö
Published: May 2022

Colitis is a major risk factor for the development of colorectal cancer, leading to colitis-associated colorectal cancer (CAC). The most commonly used animal model to study CAC is the azoxymethane-dextran sulphate-sodium (AOM/DSS) model. The ideal experimental conditions of this model depend on several factors, including the used mouse strain. No data on feasibility and conditions for older mice, e.g., for aging studies, have yet been reported. Thus, we conducted a descriptive, observational pilot study where CAC was induced in 14-month-old female Balb/C and C57/Bl6 mice using 12.5 mg/kg AOM i.p. and three different concentrations of DSS (1, 2, and 3%) in drinking water (ad. lib.). The mice were monitored regularly during the three-month experimental phase. After euthanasia, the colons of the mice were evaluated macroscopically and microscopically. Both the mouse strains showed a DSS-concentration-dependent induction of CAC. Carcinomas were only observed at 3% DSS. The DSS dose was found to be significantly correlated with the histology score and % Ki67 positive cells only in C57/Bl6 mice but not in Balb/C mice, which showed a variable response to the CAC induction. No differences in colon length, weight, or mucin content were observed. Optimal conditions for CAC induction in these aged animals are thus considered to be 3% DSS, as carcinomas did not develop when 2% DSS was used. On the other hand, Balb/C mice reacted severely to 3% DSS, indicating that 2.5% DSS may be the “sweet spot” for future experiments comparing CAC in aged Balb/C and C57/Bl6 mice. This model will allow investigation of the effect of aging on CAC development and therapy.
High-Fat Diet Impairs Muscle Function and Increases the Risk of Environmental Heatstroke in Mice
Authors: Serano Matteo , Paolini Cecilia , Michelucci Antonio , Pietrangelo Laura , Guarnier Flavia A. , Protasi Feliciano
Published: May 2022

Environmental heat-stroke (HS) is a life-threatening response often triggered by hot and humid weather. Several lines of evidence indicate that HS is caused by excessive heat production in skeletal muscle, which in turn is the result of abnormal Ca2+ leak from the sarcoplasmic reticulum (SR) and excessive production of oxidative species of oxygen and nitrogen. As a high fat diet is known to increase oxidative stress, the objective of the present study was to investigate the effects of 3 months of high-fat diet (HFD) on the HS susceptibility of wild type (WT) mice. HS susceptibility was tested in an environmental chamber where 4 months old WT mice were exposed to heat stress (41 °C for 1 h). In comparison with mice fed with a regular diet, mice fed with HFD showed: (a) increased body weight and accumulation of adipose tissue; (b) elevated oxidative stress in skeletal muscles; (c) increased heat generation and oxygen consumption during exposure to heat stress; and finally, (d) enhanced sensitivity to both temperature and caffeine of isolated muscles during in-vitro contracture test. These data (a) suggest that HFD predisposes WT mice to heat stress and (b) could have implications for guidelines regarding food intake during periods of intense environmental heat.
Enrichment of Tumor-Infiltrating B Cells in Group 4 Medulloblastoma in Children
Authors: Wu Kuo-Sheng , Jian Ting-Yan , Sung Shian-Ying , Hsieh Chia-Ling , Huang Man-Hsu , Fang Chia-Lang , Wong Tai-Tong , Lin Yu-Ling
Published: May 2022

Medulloblastoma (MB) is the most common malignant brain tumor in children. It is classified into core molecular subgroups (wingless activated (WNT), sonic hedgehog activated (SHH), Group 3 (G3), and Group 4 (G4)). In this study, we analyzed the tumor-infiltrating immune cells and cytokine profiles of 70 MB patients in Taiwan using transcriptome data. In parallel, immune cell composition in tumors from the SickKids cohort dataset was also analyzed to confirm the findings. The clinical cohort data showed the WNT and G4 MB patients had lower recurrence rates and better 5-year relapse-free survival (RFP) compared with the SHH and G3 MB patients, among the four subgroups of MB. We found tumor-infiltrating B cells (TIL-Bs) enriched in the G4 subgroups in the Taiwanese MB patients and the SickKids cohort dataset. In the G4 subgroups, the patients with a high level of TIL-Bs had better 5-year overall survival. Mast cells presented in G4 MB tumors were positively correlated with TIL-Bs. Higher levels of CXCL13, IL-36γ, and CCL27 were found compared to other subgroups or normal brains. These three cytokines, B cells and mast cells contributed to the unique immune microenvironment in G4 MB tumors. Therefore, B-cell enrichment is a G4-subgroup-specific immune signature and the presence of B cells may be an indicator of a better prognosis in G4 MB patients.
Short-Term Blockade of Pro-Inflammatory Alarmin S100A9 Favorably Modulates Left Ventricle Proteome and Related Signaling Pathways Involved in Post-Myocardial Infarction Recovery
Authors: Boteanu Raluca Maria , Suica Viorel-Iulian , Uyy Elena , Ivan Luminita , Cerveanu-Hogas Aurel , Mares Razvan Gheorghita , Simionescu Maya , Schiopu Alexandru , Antohe Felicia
Published: May 2022

Prognosis after myocardial infarction (MI) varies greatly depending on the extent of damaged area and the management of biological processes during recovery. Reportedly, the inhibition of the pro-inflammatory S100A9 reduces myocardial damage after MI. We hypothesize that a S100A9 blockade induces changes of major signaling pathways implicated in post-MI healing. Mass spectrometry-based proteomics and gene analyses of infarcted mice left ventricle were performed. The S100A9 blocker (ABR-23890) was given for 3 days after coronary ligation. At 3 and 7 days post-MI, ventricle samples were analyzed versus control and Sham-operated mice. Blockade of S100A9 modulated the expressed proteins involved in five biological processes: leukocyte cell–cell adhesion, regulation of the muscle cell apoptotic process, regulation of the intrinsic apoptotic signaling pathway, sarcomere organization and cardiac muscle hypertrophy. The blocker induced regulation of 36 proteins interacting with or targeted by the cellular tumor antigen p53, prevented myocardial compensatory hypertrophy, and reduced cardiac markers of post-ischemic stress. The blockade effect was prominent at day 7 post-MI when the quantitative features of the ventricle proteome were closer to controls. Blockade of S100A9 restores key biological processes altered post-MI. These processes could be valuable new pharmacological targets for the treatment of ischemic heart. Mass spectrometry data are available via ProteomeXchange with identifier PXD033683.
A New Data-Preprocessing-Related Taxonomy of Sensors for IoT Applications
Authors: Rosero-Montalvo Paul D. , López-Batista Vivian F. , Peluffo-Ordóñez Diego H.
Published: May 2022

IoT devices play a fundamental role in the machine learning (ML) application pipeline, as they collect rich data for model training using sensors. However, this process can be affected by uncontrollable variables that introduce errors into the data, resulting in a higher computational cost to eliminate them. Thus, selecting the most suitable algorithm for this pre-processing step on-device can reduce ML model complexity and unnecessary bandwidth usage for cloud processing. Therefore, this work presents a new sensor taxonomy with which to deploy data pre-processing on an IoT device by using a specific filter for each data type that the system handles. We define statistical and functional performance metrics to perform filter selection. Experimental results show that the Butterworth filter is a suitable solution for invariant sampling rates, while the Savi–Golay and medium filters are appropriate choices for variable sampling rates.