bluuebunny/crossref_metadata_2025 huggingface dataset:
Inovasi Digital LIBERTI (Literasi Berbasis Tekhnologi Informasi) sebagai Sarana Pembelajaran Sekolah di SMP Negeri 2 Cisauk Kabupaten Tangerang
Authors: Andreany Selfy
Published: October 2022

Penelitian ini adalah tentang inovasi digital bernama LIBERTI (Literasi Berbasis Tekhnologi Informasi) sebagai sarana pembelajaran sekolah di SMP Negeri 2 Cisauk. Kajian ini dilakukan oleh Pemerintah Daerah Kabupaten Tanggerang. Penelitian ini penting dan relevan karena melihat kondisi peserta didik di SMP N 2 Cisauk Kabupaten Tanggerang. Selain itu, penelitian ini adalah bentuk upaya pemerintah daerah dalam meningkatkan kualitas pendidikan di era revolusi Industri 4.0. Diharapkan dapat memudahkan cara mengajar pendidik dan cara belajar peserta didik. Populasi dalam penelitian ini yaitu daerah yang telah melakukan kebijakan atau inovasi dalam bidang digital dan pendidikan. Sedangkan sampel dalam penelitian ini adalah inovasi “LIBERTI” (Literasi Berbasis Informasi Teknologi). Hasil kegiatan yang sudah diterapkan dari pemanfaatan literasi LIBERTI ini antara lain : setiap hari di seluruh jam mata pelajaran dapat efektif, merubah pola pikir peserta didik untuk lebih mandiri belajar, memecahkan problem solving dalam model pembelajaran serta batasan dalam penggunaan yang tepat, memberikan pengalaman tentang sumber teknologi yang baik bersama pendampingan, mencari informasi ilmu sesuai mata pelajarannya secara visual maupun non visual, memberikan kebiasaan baik untuk menggunakan sosial media secara tepat dan sesuai kebutuhan sekaligus sebagai gudang informasi ilmu yang akurat.
تاريخ القدس والخليل
Authors: محمد بن محمد بن شرف الدين الخليلي شمس الدين
Published: October 2022

تنبع أهمية هذا الكتاب من كونه يعالج فترة زمنيّة مهمة من التاريخ "الديني" المحلي لمدينتي القدس والخليل، والحالة التي آلَ إليها المسجد الأقصى، وقبة الصخرة المشرّفة، والمسجد الإبراهيمي، ومقامات الأنبياء عليهم السلام خلال الفترة ما بين 1075هـ/1663م - 1126هـ/1714م، وذلك نتيجة الاستيلاء على أوقاف هذه الأماكن الدينية. كما يتناول الكتاب الإصلاحات التي قام بها الوزير رجب باشا خلال فترة ولايته المتمثّلة بضبط الأوقاف، والكشف على ما استحدثه المسيحيّون في كنائسهم من ترميمٍ لقنواة المياه وجلب الماء لأهالي القدس والمسجد الأقصى. كما يتناول الكتاب حالة الأمن في قضاء القدس الشريف.
Cómo bautizar un diálogo entre culturas
Authors: Zafra Castaño Aurora
Published: October 2022

La importancia e impacto que tienen las palabras, pasa muchas veces desapercibido en lo utilitarista del idioma y en las necesidades cotidianas. En este artículo se expone la necesidad de usar términos apropiados, pero no en el sentido de la normalización y aceptación de estos, sino en la necesidad de encontrar conceptos que abarquen lo que se quiere expresar. Este llamado a la reflexión, es con el fin de confrontar uno de los términos más normalizados y usados en la actualidad: ‘inclusión’, palabra notoria y que por su popularidad reciente es común encontrarla en artículos, comerciales, etc. En el escrito se resalta cómo este término es limitado y expresa un sesgo, en particular para hacer referencia al acto de “incluir” a una cultura diferente en el eje cultural predominante. Para finalizar, el artículo expone un nuevo concepto, que puede ser más reflexivo al momento de describir estos encuentros culturales.
Historias de heridas, caminos de sanación
Authors: Miramonti Angelo
Published: October 2022

El artículo presenta los resultados de un taller de investigación—creación con mujeres afrodescendientes e indígenas, víctimas de violencia sexual en el conflicto armado colombiano . El método utilizado fue la investigación-acción, donde el autor diseñó y facilitó un taller que incluía la construcción de espacios rituales para compartir relatos autobiográficos, y una puesta en escena, en la cual actuaron las mismas personas que habían vivido la historia. El proceso dio dos tipos de resultados. El primero (de tipo creativo) fue un ritual, diseñado por las mujeres, y una obra teatral donde cada participante interpretaba su propia historia. El segundo resultado (psicosocial) fue que el taller contribuyó a sanar las heridas de las participantes y a visibilizar sus historias; la puesta en escena y la presentación a un público externo, les permitió a las protagonistas pasar de sentirse víctimas a identificarse como testigos del conflicto armado, y a redefinir su identidad como constructoras de memoria colectiva y actrices de convivencia y no repetición. En conclusión, el autor recomienda la inclusión intencional y sistemática de métodos artísticos, performativos y testimoniales, en todos procesos de construcción de paz y de promoción de la convivencia y de la no repetición.
Aquelarre del tedio y una flor
Authors: Mina Jesús María
Published: October 2022

Sociedad líquida, de las incertidumbres y la hiperrealidad, tiempo de virtualidad y del no aquí, no ahora. Emergencias. Vivimos inmersos en los conjuros de premuras y ocupaciones que, con el reloj y el síndrome de la ocupación, se forja un altar. Periodo de ausencias y presencias, del deseo por la ubicuidad ante las demandas de prisa y de competitividad. Ante las premuras, los compromisos se inciertan. Sociedad del aprendizaje que hace de la inseguridad su mayor tesoro.
Strana tijela donjeg dišnog puta kod djece u Kliničkom bolničkom centru Split tijekom razdoblja 2010.-2020.godine
Authors: Kordić Marko , Poljak Nikola Kolja , Polić Branka , Kontić Mirko
Published: October 2022

Uvod: Aspiracija stranoga tijela predstavlja značajan uzrok bolesti i smrti tijekom djetinjstva. Cilj ovoga istraživanja bio je odrediti postotak pronađenih i uspješno odstranjenih stranih tijela prilikom traheobronhoskopije, kao i njihovu vrstu i lokalizaciju, te utvrditi postoji li razlika u demografskim, kliničkim i radiološkim obilježjima među skupinama sa i bez stranog tijela. Bolesnici i metode: Proveli smo retrospektivnu studiju u koju je uključeno 62 ispitanika kojima je u Kliničkom bolničkom centru Split učinjena traheobronhoskopija zbog sumnje na aspiraciju stranoga tijela, tijekom razdoblja od 1.1.2010. do 31.12.2020. Prikupljeni podaci za svakog ispitanika uključivali su: dob, spol, nalaz traheobronhoskopije, radiološke nalaze i kliničke podatke. Ovisno o nalazu traheobronhoskopije, podijelili smo ispitanike u dvije skupine: skupina s pronađenim stranim tijelom (n=32) i skupina u kojoj strano tijelo nije pronađeno (n=30). Za statističku analizu koristili smo hi-kvadrat i Fisherov egzaktni test, te smo razinu statističke značajnosti postavili na P<0,05. Rezultati: Strano tijelo pronađeno je u 32 (51,6%) bolesnika kojima je učinjena traheobronhoskopija, a uspješno je odstranjeno njih 31 (96,9%). Medijan dobi u skupini sa stranim tijelom iznosio je 20,5 mjeseci (15,3-35,5 mjeseci). Najveća incidencija, njih 19 (59,4%) bila je u dobi između prve i treće godine. U skupini sa stranim tijelom (n=32) dječaci čine većinu – 22 (68,8%) u odnosu na djevojčice – 10 (31,2%), u omjeru 2,2:1. Većina stranih tijela bila je organskoga podrijetla (87,5%), a najčešće pronađeno strano tijelo bilo je kikiriki (37,5%). Strano tijelo bilo je lokalizirano podjednako u desnom glavnom bronhu (43,75%), kao i u lijevom (43,75%), u oba glavna bronha nađeno je stranih tijela u 3,1% slučajeva, a u dušniku 9,4%. Korištenje pomoćne dišne muskulature (P=0,024), auskultacijski smanjen šum disanja (P=0,001), dispneja (P=0,046), emfizem (P=0,011) i pomak medijastinuma (P=0,011) statistički su značajno češći u skupini sa stranim tijelom. Radiološki netransparentno strano tijelo bilo je prisutno u 9,4% bolesnika kojima je strano tijelo pronađeno, a kod 46,9% bolesnika imalo je uredan nalaz radiograma pluća. Zaključci: Kod djeteta s dispnejom, korištenjem pomoćne dišne muskulature, auskultacijski smanjenim šumom disanja, te emfizemom i pomakom medijastinuma na radiogramu pluća, potrebno je posumnjati na aspiraciju stranoga tijela u donjim dišnim putovima, te učiniti rigidnu traheobronhoskopiju kao dijagnostičku i terapijsku metodu.
Um Panorama Comparativo de Arquiteturas de Digital Twin no Contexto de Internet das Coisas
Authors: Oliveira Renato Alves de , Rocha Atslands Rego da , Oliveira Carina Teixeira de
Published: October 2022

O crescimento da Internet das Coisas (Internet of Things - IoT) a nível global vem atraindo cada vez mais atenção para estudos relacionados ao tema. No contexto de IoT, um tema que vem ganhando grande relevância nos âmbitos mercadológico e acadêmico é o Gêmeo Digital (Digital Twin - DT). Dentre as principais questões em aberto neste tema, destaca-se a inexistência de um padrão arquitetural genérico e unificado, que englobe as necessidades essenciais de um projeto de DT. Este artigo apresenta um panorama comparativo de arquiteturas modernas de DT no contexto de IoT. Os resultados apresentados apontam diretrizes capazes de ajudar projetistas e pesquisadores no planejamento de arquiteturas de DT em cenários IoT.
Abordagem Multidisciplinar para Ensino-Aprendizagem de Projetos de Sistemas Computacionais com Apoio do CompSim
Authors: Lisboa Edson B. , Esmeraldo Guilherme Álvaro R. M. , Feitosa Robson Gonçalves F. , Proto Eduardo Carlos P. da Silva , Barros Edna Natividade da S. , Melo Ingrid Sofia V. de
Published: October 2022

Com a evolução tecnológica, os processos de ensino-aprendizagem em projetos de sistemas computacionais tiveram que acompanhar a complexidade dos novos sistemas. Na literatura científica, tem-se utilizado os simuladores computacionais como ferramenta de apoio pedagógico, porém os mesmos não estão preparados para atender a essas novas demandas educacionais. Assim, este trabalho propõe uma abordagem de ensino-aprendizado multidisciplinar em projetos de sistemas computacionais, que tem como apoio a simulação computacional e práticas com componentes eletrônicos reais, para promover uma aprendizagem significativa, considerando aspectos metodológicos que impulsionam a formação profissional e tecnológica.
Aplicativo e-SUS Território: Ferramenta para a gestão do território na Atenção Primária à Saúde do Brasil
Authors: Celuppi Ianka Cristina , Prado Ricardo Luiz Camargo , Hammes Jades Fernando , Dalmarco Eduardo Monguilhott , Wazlawick Raul Sidnei
Published: October 2022

The objective of this work is to present the e-SUS Territory application and contextualize its contribution to the qualification of citizen data registration, consolidated analysis of the health conditions of communities, and the work process of Community Health Agents in Primary Health Care. The usability data show that the use of this app has significantly expanded in the last four years, in order to contribute to the production of Community Health Agents and analysis of the health conditions of the territory. Currently, the application has about 141,000 active users per month, contributing to the health of 70,350,211 Brazilians. Monthly submissions of production files are also significant, totaling 23,849,941 home visits, 4,194,149 editions or new individual registrations, and 2,261,138 editions or new registrations of families and households in June of this year. Thus, the e-SUS Territory is understood as an important tool for working and managing the territory of Brazilian Primary Health Care.
OIEAnnotator: Uma ferramenta para construção e anotação de corpora para Extração de Informação Aberta
Authors: Tironi Igor , Claro Daniela Barreiro
Published: October 2022

A disponibilidade de corpora anotados é uma importante tarefa de Open Information Extraction (Open IE). Porém, essa é uma tarefa difícil pois demanda trabalho manual de anotadores. Essa tarefa se torna ainda mais complicada no contexto da língua portuguesa, dada a sua complexidade e a falta de uma estrutura prévia para tarefas de anotação nesta língua. Ferramentas que possam agilizar esse processo tem um grande valor para a construção de conhecimento nesta área. Esse trabalho propôs uma ferramenta capaz de auxiliar no processo de construção de corpora anotados, através da anotação e identificação de novas triplas relacionais nas sentenças. Para validação, foi definido um grupo de especialistas, composto por três especialistas na tarefa, e um grupo de controle, composto por indivíduos sem conhecimento no processo para teste de usabilidade da ferramenta. A ferramenta foi utilizada para anotação de um corpus em português, mas não foi identificado nenhum impedimento para a utilização desta para outras linguas.
CaçaFake: A System for Monitoring and Analyzing Low Credibility Websites in Brazil
Authors: Silva Márcio , Reis Julio C. S. , Couto João M. M. , Araújo Leandro , Maduro João , Silva Ana P. C. , Almeida Jussara M. , Benevenuto Fabrício
Published: October 2022

Combating the spread of misinformation is a complex task. In addition, digital platforms (e.g., social networks, instant messaging apps, etc) enhance the dissemination of content produced by low redibility websites. Thus, monitoring and understanding the main characteristics of these websites has become an important task to interrupt the generation chain and spread of misinformation in our society. In this work, we propose a system called CaçaFake in order to speed up the investigation process by supervisory bodies in the fight against misinformation. Our system displays characteristics associated to websites of low credibility which may be useful to regulatory bodies in their decision-making process, creating a rich resource in the fight against misinformation in Brazil.
Mobility in the age of massive data: opportunities and challenges
Authors: Ferreira Douglas , Lucas Fabricio , Gonçalves José , Kassio Pedro , Oliveira Samuel , Aurelio Yuri , Bergamo Gustavo , Born Paulo , Ciarlini Angelo
Published: October 2022

The development of IoT and machine learning in recent years has brought new opportunities to the mobility industry. The amount of data collected from the fleet with telemetry is not only more accurate but also more available with lower IoT costs. Customers’ experience and profitability can be dramatically improved by means of using IoT datasets and machine learning models. These opportunities however come together with Big Data challenges. In this paper, we describe some of the opportunities and challenges that Localiza, the largest car rental company in Brazil, has been addressing as part of its digital transformation.
Cemented Carbide Layer Thickness Optimization of Carbide Anvil Based on Thermodynamic Coupling
Authors: XIE Guizhong , WANG Tao , WANG Liangwen , GONG Xiaoyun , ZHANG Shixin , ZHI Zeheng , ZHAO Ziyong , YANG Xiaojun
Published: October 2022

This paper presents cemented carbide layer thickness optimization of a carbide anvil based on thermodynamic coupling analysis. In our method, the established carbide anvil system through SolidWorks is firstly imported into the finite element software. The temperature field and thermal-mechanical coupling field of the carbide anvil system are analyzed. From the simulation results, it can be found that the contact stress of steel ring under temperature load is increased by 17.9% compared with that without temperature load. Thus, the service life of carbide anvil under temperature load is lower than that without temperature load. In addition, the four edges of anvil are prone to fatigue cracks due to the phenomenon of shear stress concentration. This is consistent with the actual crack location of cemented carbide anvil, which verifies the accuracy and rationality of thermal-mechanical coupling simulation. The thickness of cemented carbide layer is optimized based on thermodynamic coupling. The optimization results show that the thickness of 1.8cm is the best when size ranges from 1.8cm to 2.2cm. The maximum contact stress, the maximum shear stress, the temperature are all reduced by 387.5MPa, 110.55MPa, and 10.11℃, respectively.
„Man kann hier die Wirksamkeit spüren“
Authors: Löffler Eva Maria
Published: October 2022

Aus professionstheoretischer Perspektive rekonstruiert die vorliegende Untersuchung das professionelle Handeln von Sozialarbeiter:innen in Krankenhaussozialdiensten. Im Beitrag werden einführend die sozialrechtlichen Grundlagen Sozialer Arbeit im Krankenhaus dargelegt. Anschließend werden die gewählte theoretische Perspektive und die eigene Studie erläutert. Darauf aufbauend werden die empirischen Erkenntnisse skizziert und abschließend ausgewählte Aspekte diskutiert.
Vorbeugende Sozialpolitik durch kommunale Unterstützungsangebote für pflegende Angehörige
Authors: Bohnet-Joschko Sabine , Loboiko Katharina , Zippel Claus
Published: October 2022

Die Unterstützung von pflegenden Angehörigen ist eine zentrale und zunehmend wichtige gesellschaftliche und politische Aufgabe. Angesichts der Ausdifferenzierung von Unterstützungsangeboten für Pflegebedürftige wie auch für pflegende Angehörige kommt den Kommunen eine besondere Rolle bei der Etablierung von Koordinations- und Dienstleistungsstrukturen vor Ort zu. In diesem Beitrag diskutieren wir die Chancen und Herausforderungen von Methoden der Wirkungsanalyse am Beispiel kommunaler Unterstützungsleistungen für pflegende Angehörige.
ArcelorMittal, Zenica: the logic of collective action
Authors: Scherrer Peter
Published: October 2022

This article explores a recent successful threat of industrial action at the ArcelorMittal steel plant at Zenica, Bosnia and Herzegovina. Building in interviews with trade unions leaders, the author locates the campaign against the background of the economic, political and social situation in the country as well as the difficulties these impose on effective trade union organisation which, with certain exceptions, exists at a low level particularly in the private sector. Other aspects also make trade unions unattractive, not least to young people. Consequently, examples of industrial action which are successful are not only are of practical assistance in raising the wages of the workers involved, they also provide powerful examples of the continuing logic of collective action and, thus, a strong motivation to seek out trade union membership. Furthermore, in a country beset by the political problems that Bosnia and Herzegovina has, examples of strike action - of workers simply getting on with their everyday normal lives - also act to reassert what is most important by documenting citizens in their lives as workers not as ethnicities.
Implikationen des Lieferkettensorgfaltspflichtengesetzes auf öffentliche Unternehmen – Verpflichtung, Umsetzungsempfehlungen für die Corporate Governance und Berichtsnotwendigkeiten
Authors: Müller Stefan , Otter Nadine
Published: October 2022

Der deutsche Gesetzgeber verpflichtet ab dem 1.1.2023 auch öffentliche Unternehmen mit mind. 3.000 beschäftigten Personen (bzw. ab dem 1.1.2024 mit 1.000 Beschäftigten) im Lieferkettensorgfaltspflichtengesetz (LkSG) zur strengeren Überwachung der Zulieferer bezüglich der Einhaltung von bestimmten Menschenrechten und Umweltschutzbelangen sowie zur Berichterstattung darüber. Damit werden bislang eher freiwillige Standards einer guten Corporate Governance im Unternehmen und darüber hinaus in der Lieferkette nun gesetzlich vorgeschrieben. Die Sanktionierung reicht von Bußgeldern über Transparenzanforderungen (Reputationsrisiko) bis hin zu der Regelung des zivilrechtlichen Klagerechts.
MicroRNAs and Male Infertility
Authors: Munawar Mohsin , Liaqat Irfana , Ali Shaukat
Published: October 2022

Spermatozoan production is tightly controlled by the multistep process of spermatogenesis and spermiogenesis. Physiological and molecular disruption in spermatogenesis can lead to various reproductive disorders including male infertility. Male infertility is associated with various etiologies, but mechanism is not determined yet. MicroRNAs (miRNAs) are almost 22 nucleotides long, non-protein coding RNA that play an essential role in posttranscriptional regulations in various biological processes including spermatogenesis. The current review is aimed to summarize the recent literature on the role of miRNAs in male infertility and spermatogenesis and their potential in diagnosis, prognosis, and therapy of the disease. miRNAs have shown tremendous potential to be used as diagnostic and prognostic marker and therapeutic target in diseases related to male infertility. Experimental evidence reveals that aberrant expression of miRNAs affects different cell types and different stages of spermatogenesis, which ultimately leads to male infertility. To exploit the full potential of miRNAs, characterization of unidentified miRNAs is required to understand the miRNA-mediated regulatory mechanism related to male infertility.
Ommochromes of the Compound Eye of Arthropods from the Insects and Crustaceans Classes: Physicochemical Properties and Antioxidant Activity
Authors: E. Dontsov Alexander , A. Ostrovsky Mikhail
Published: October 2022

The chapter is devoted to the study of the physicochemical properties of the ommochromes of the compound eye of arthropods. Ommochromes are the characteristic pigments of invertebrates. They are believed to function in the eyes as screening and protective pigments that protect photoreceptor cells from the damaging effects of light. Ommochromes were isolated, purified, and obtained in preparative quantities from crustaceans (Crustacea; order Decapoda) and insects (Insecta; families Stratiomyidae, Sphingidae, Blaberidae, Acrididae, and Tenebrionidae). The physicochemical properties of the isolated ommochromes were studied by absorption and fluorescence spectroscopy, electron spin resonance (ESR) and Mossbauer spectroscopy, and high-performance liquid chromatography. The antioxidant activity of ommochromes was studied by methods of inhibiting lipid peroxidation induced by reactive oxygen species and variable valence metal ions and by quenching luminol chemiluminescence. The data obtained are important both for understanding the biological functions of arthropod eye ommochromes and for the development of new pharmacological preparations based on ommochromes for the prevention and treatment of pathologies associated with the development of oxidative stress.
Drugs and Biodiversity Loss: Narcotraffic-Linked Landscape Change in Guatemala
Authors: N. Winter Steven , Eastwood Gillian , A. Barrios-Izás Manuel
Published: October 2022

Characteristic of the Anthropocene, human impacts have resulted in worldwide losses in forested land cover, which can directly and indirectly drive biodiversity loss. The global illicit drug trade is one source of deforestation directly implicated with habitat loss in Central America, typically for drug trafficking and livestock production for money laundering. Given reports of deforestation in Central America linked to narcotraffic, we explored vegetation changes within Guatemala’s highly biodiverse Maya Biosphere Reserve by examining trends suggestive of deforestation in a protected area. As such, we collected satellite-derived data in the form of enhanced vegetation index (EVI), as well as history of burned areas, published human-“footprint” data, official population density, and artificial light activity in Laguna del Tigre National Park from 2002 to 2020 for descriptive analysis. We found consistent reductions in EVI and trends of anomalous losses of vegetation despite a baseline accounting for variation within the park. Analyses revealed weak correlations (R2 ≤ 0.26) between EVI losses and official sources of anthropogenic data, which may be attributable to the data’s limited spatial and temporal resolution. Alarmingly, simple analyses identified vegetation losses within a protected area, thus emphasizing the need for additional monitoring and science-based, but interdisciplinary policies to protect this biodiversity hotspot.
Virtual Reality in Stereometry Training
Authors: Lebamovski Penio
Published: October 2022

A new stereoscopic system is presented in this chapter for training in stereometry. Virtual reality systems are two types: immersion and non-immersion. An example of a environments with immersion is the desktop computer in which the virtual world is displayed on a special stereoscopic monitor through 3D glasses. The HMD (Head Mounted Display) virtual helmet is an example of an immersion system. The new stereoscopic system can also implement both types of 3D technology. At the same time, the software can generate objects in the .obj file extension to print to a 3D printer or add to a virtual reality device. The 3D technology is one of the fastest-growing. Over the last decade, it has found application in almost all spheres of society, including education. In learning stereometry, a problem may arise in drawing the geometric figures, unlike planimetry, where the drawing 100% coincides with its original. The problem can be solved with the help of specialized 3D software.
Neural Structure and Function in Autism Spectrum Disorder
Authors: Plens Shecaira Tânia , Miriã da Silva Santos Thais , Barbosa Lopes Nayara , Ribeiro Miedes Leonardo , Porto Matrone Fabrício , Bernardes Nathalia
Published: October 2022

Autism spectrum disorder (ASD) refers to a group of neurodevelopmental disorders characterized by changes in communication, social interaction, and repetitive behavior, recognized as a public health problem with a sharp increase in its prevalence in the world population. It is known that brain functioning in individuals with ASD presents important deficits. It is essential to understand these deficits to identify and promote new management strategies for the development of this population with ASD. In this sense, the objective of this chapter is to present, through a literature review, the main risk factors that make up ASD, by showing classic and current findings based on neurophysiological changes and treatments.
Short-Segment Schanz Pedicle Screw Oblique Downward Fixation for Thoracolumbar Burst Fractures: A New Method for the Reduction of Intraspinal Bone Fragments
Authors: Yang Sheng , Xia Chunyang
Published: October 2022

Short-segment pedicle screw internal fixation for thoracolumbar burst fracture has been widely used in clinic. When the fracture fragment enters the spinal canal seriously, it is often necessary to decompress. The authors pioneered the reduction of fracture fragments in the spinal canal by direct traction with pedicle screws implanted obliquely downward without lamina decompression. Compared with the previous pedicle screw parallel endplate fixation and lamina decompression, this new method has less trauma, better reduction and can remove the internal fixation after fracture healing. Compared with conventional pedicle screws, short-segment Schanz pedicle screws are more similar to normal posterior columns in structure and stress conduction and have better safety and stability, so the latter is more suitable for the treatment of severe burst fractures.
Welding Deformation Characteristics and Mitigation Method of Hub Flange
Authors: Roh Ji-Sun , Park Chang-Woo , Park Jung-Goo
Published: October 2022

This paper considers a 3-D thermos-mechanical analysis to investigate the effect of welding direction, tack weld, root gap and welding process on welding deformation in hub flange and pipe joint. Multi-pass welding for a single ‘V’ butt-weld joint geometry is simulated and 3-D weld path analysis is used with realistic weld bead. 3 different welding direction (2-path, 4-path diagonally, 4-path from the bottom) are analyzed and how the presence or absence of tack weld affects deformation was analyzed. Also, 3 different cases for root gaps (2, 3, 4mm) are considered and finite element analysis results are compared. In addition, the effects of the welding process on the hub flange face are determined. From the results, perpendicularity of the hub flange face is found to be strongly dependent on the welding direction and tack welds. On the other hand, root gap has small influence for tilting. The results also showed the feasibility of mitigating and controlling the welding deformation, and optimum selection of welding method was confirmed.
Proto-magnetars within quasiparticle model
Authors: Yi-Nong Wang  , Peng-Cheng Chu  , Yao-Yao Jiang  , Xiao-Di Pang  , Sheng-Bo Wang  , Pei-Xin Li  ,   Qingdao University of Technology, School of Science, Qingdao 266033, China
Published: October 2022

We investigate the thermodynamical properties of strange quark matter (SQM) at zero/finite temperature and under constant magnetic field within quasiparticle model. The quark matter symmetry energy, energy per baryon, free energy per baryon, anisotropic pressures are also studied and the result indicates that both the effects of temperature and magnetic field can significantly influence the thermodynamical properties of quark matter and proto-quark stars (PQSs). Our result also indicates that the maximum mass and the core temperature of PQSs not only depends on the heating process at the isentropic stages, but also but also the magnetic field strength and orientation distribution inside the magnetar within quasiparticle model.
CROSS-SECTIONAL SURVEY TO DEVELOP VALIDATED SCALES FOR ASSESSMENT OF JEERNA AAHARA LAKSHANAS
Authors: Hegde Manaswi S , Naragund Shivanand B , Goud Kiran M , BV Priyanka
Published: October 2022

Digestion of food is the mainspring of nourishment of the body. Jatharagni (strength of digestion) plays a vital role in digestion. As digestion progresses, our body shows the signs that reflect the digestion stage known as Jeerna Aahara Lakshanas. This research aimed to develop and validate a scale for assessing Jeerna Aahara Lakshanas using standardized questionnaire development and validation methods. In the developmental phase, Jeerna Aahara Lakshanas were collected from the Samhitas of Ayurveda. The factors that influence digestion, like Ahara Vidhi Vidhana (Rules for food consumption) and Loulya (greediness for food), are also considered in developing the questionnaire. Keeping the information available in texts of Ayurveda Charaka Samhitha and Ashtanga Hridaya as primary information, Open-ended questions were formed under different domains and subdomains of Jeerna Ahara Lakshanas. The domains and questions were validated by 25 Ayurvedic academicians, practitioners. A set of closed-ended questions was developed based on a 5 and 7 Likert scale response. In the validation process, the closed-ended questions were distributed to 200 healthy volunteers of both genders aged 18-40 after screening health with an SF 12 questionnaire, with prior consent in each stage. The response was analyzed using SPSS 2.0 software, and an assessment of reliability was carried out by adopting the data reduction. The reliability was assessed using the standard Cronbach’s Alpha (CA) test. The questions which didn’t give the acceptable CA were redacted, and the questions with good and acceptable CA were retained. The final questionnaire was obtained with 51 questions after obtaining a CA of 0.826 in the 5th stage.
A REVIEW ON UTILITY OF DWIVIDHOPAKRAMANIYA CHIKITSA IN SANDHISHOOLA
Authors: Mathad Prasanna , Mathad Anagha
Published: October 2022

Dwividhopakraminiya chikitsa explained in Ashtanga Hridaya Sutra Sthana chapter-14 as the two kinds of significant line of treatments as Santarpana and Aptarpana chikitsa in the form of Brimhana and langhana for two types of the human body. One is nourishing therapy, and another is depleting therapy. Sandhishoola is the common symptom found in the Sandhigata vata, Amavata or Vatarakta diseases in the different age groups of people. Among vataj gatavat vyadhis, Sandhigata vata is the most commonly observed condition correlated to Osteoarthritis (OA), predominantly seen in degenerative disease involving peripheral joints cartilage damages overgrowth of the bone. The prevalence rate of OA has been observed to increase with the advancing age, and the possibility of women being affected by the disease is greater than men with respect to gender. In the Amavata and Vatarakta also, Sandhishoola is observed along with inflammation of joints. Hence, in this article, the application of dwividhopakraminiya chikitsa for sandhishoola in different diseases has been explained. The mode of action of Santarpana and Apatarpana chikitsa in managing degenerative and inflammatory conditions of the joints.
A REVIEW ON SEASONS AND SEASONAL REGIMENS: NEED OF REDEFINING KERALA MODEL: FROM PRACTICE TO PRINCIPLE
Authors: Surayya K , Kirathamoorthy P P
Published: October 2022

Ritu, the season, is classified according to different features that affect our bodies and the environment. The basic principle followed in Ayurveda is Swastahsya swasthyarakshana & Athurasya vikaraprasamana, which means Ayurveda emphasises maintaining health and preventing diseases by following proper dietetics and lifestyle regimen rather than just treatment and cure of the diseases. This can be achieved by changing diet and practices in response to changes in climatic conditions. For this purpose, Dinacharya and Ritucharya have been mentioned in the classics. Ayurveda gives equal importance to both prevention and cure of disease. Generally, India has six major types of seasons. But the climate of India comprises a wide range of variations due to geographical diversity. The role of Pitta in seasonal patterns seems to be different in Kerala compared to a pan Indian pattern. Relationship of pitta in greeshma and varsha ritu needs revision. Kerala's traditional pattern of Rituchaya seems to endorse the role of pitta to a more considerable extent. The enquiry should direct from practice to principle, instead of a usual dynamic from Principles to Practice, because tradition focus on technique rather than principle. This paper highlights the need to revise seasonal regimens suitable in a regional context based on panchavayava vakya.
A REVIEW ARTICLE ON VARIOUS DHOOPANA YOGA’S MENTIONED IN AYURVEDIC LITERATURE
Authors: IT Mallinath , JV Adithya , Aradhyamath Siddayya
Published: October 2022

Dhoopana means fumigation. Fumigation/dhupana is done with the help of dhupana dravyas vis-à-vis fumigants. Fumigants are the materials that fumigate the area with smoke having a characteristic odour when ignited. When Varthi is ignited with fire, the active phytochemical compounds burn to give out its essential therapeutic action based on the dravya's used. Agni-Devata (fire god) is considered the primary source or deity of Dhoopa, and the betterment of entire mankind is the main purpose of its materialization. In Ayurveda literature, we have many references to dhupana dravyas which are of both plant & animal origin. A detailed description of their mode of collection, preparation, usage of dhupana yogas, preservation, and storage is mentioned. So, exploring and understanding these fundamental concepts of dhupana and its practical utility in the day-to-day clinical practice of extracting their medicinal properties is the need of the hour.
SCIENTIFIC EXPLORATION OF CHAKRAS AND THEIR THERAPEUTIC POTENTIAL IN CANCER IN PURVIEW OF BIOENERGETIC MEDICINE: A REVIEW
Authors: Himani Sagar , Pooja Sabharwal , Amit Sharma Kumar
Published: October 2022

Cancer is one of the most outrageous diseases of the present century.According to WHO, 9.6 million deaths in 2018 were due to Cancer which accounts for 1 out of 6 worldwide deaths. Out of these, 30-50% is preventable. Despite the modern scientific evolution, this enormous burden has not been reduced. The integrated approach of Cancer therapy is highly productive to improve quality of life and survival rate. Ayurvedic treatment with a healthy diet, lifestyle modification, and mind-body medicine are beneficial. Chakras are the “switches” in the path of energy flow in an individual, representing Pranayama kosha and are subtle. These Chakras in the body create a human energy field around each human being. Chakra’s healing is a highly established system of energy-based curative techniques that utilize “PRANA” to steadiness, harmonize and renovate the body’s vital energy. The foremost factor, i.e. chakra is discussed in detail based on modern scientific knowledge. There is a massive impact of chakra healing in carcinoma as it is highly effective to improve quality of life.
On the Computation of the Minimum Polynomial and Applications
Authors: Halidias Nikolaos
Published: October 2022

Aims/Objectives: In this review article we study the computation of the minimum polynomialof a matrix A and how we can use it for the computation of the matrix An. We also describethe form of the elements of the matrix A-n and we will see that it is closely related with thecomputation of the Drazin generalized inverse of A. Next we study the computation of theexponential matrix and nally we give a simple proof of the Leverrier - Faddeev algorithm forthe computation of the characteristic polynomial.
Isolation and Characterization of Bacteria Present in the Gut of Dead Females Glossina morsitan Submorsitans Using Culture Dependent and Independent Methods
Authors: Ibrahim L. J. , Ahmed A. B. , Ndams I. S.
Published: October 2022

This study aimed to isolate and characterize bacteria present in the gut of death female Glossina morsitan submorsitans using culture dependent and independent methods. Thirty-four fresh dead female flies were obtained from the insectary of Nigerian Institute for Trypanosomiasis Research (NITR), Kaduna. The flies were surface sterilized and the mid-guts were dissected under aseptic conditions. The gut bacterial cultures were done for pregnant and non-pregnant dead female flies (6weeks- 15weeks old) a total of 20 isolates. The culture dependent methods identified six bacterial genera namely, Serratia species, Staphylococcus species, Escherichia species, Myroides species, Providencia species and Alkaligenes species. Molecular analysis only identified four (4) out of the six (6) isolates; as 4(50%) Serratia mercesens, 1(12.5%) Alcaligenes faecalis, 2(25%) Myroides odoratimus and 1(12.5%) Providencia. This is not surprising because the microorganisms were not included in the targeted spectrum of the Polymerase Chain Reaction. Our study recorded for the first time the presence of Myroides odoratimus in the gut of G. M. submorsitans in Nigeria. Some of these bacteria are pathogenic to the flies and may be the cause of mortality of laboratory reared flies. We recommend intensive research on tse tse gut bacterial flora to give insight into their use as potential vector bio-control tool.
Public Health Threats from Pet Bird Zoonoses
Authors: Nair Prasanth M. , Anil . , Sivaprasad M. S. , Anand V. M. , Akash . , Singh Amit Kumar , Yadav Sukanshi , Chouraddi Rakesh , Gujjalkar Prashant , Baby Binitha Mariam , Dhaigude Vaibhav , Jigyasha . , Durge Ajay , Prabhakar .
Published: October 2022

The very high exotic or genetic value made pet birds, likecanaries, parakeets, and parrots a choice for trade across countries and continents, and the capability of these birds to act aspotential carriers or transmitters of zoonotic diseases contributes a significant threat to humans. Birds are characterized and known for their susceptibility, transmission, and maintenance of pathogens that are zoonotic to humans. Some of the zoonotic diseases they spread, such as highly pathogenic avian influenza (HPAI), salmonellosis, and chlamydophilosishave a significant impact on human health and these things make this issue a one health concern. Zoonotic diseases among birds areclassified as bacterial, viral, fungal, and of parasitic origin. The intensity with which they affect humans varies according to their pathogenicity and virulence. The awareness of pet bird zoonosesis of prime importance while trading or domesticating the bird, which will help to understand their potential fordiseases and install preventive measures accordingly. This review paper aims to educate readers about the risks faced by bird owners and the public by describing several instances of bird-human disease transmission and the characteristicsymptoms of those diseases.
Association of the Expiration of Child Tax Credit Advance Payments With Food Insufficiency in US Households
Authors: Bovell-Ammon Allison , McCann Nicole C. , Mulugeta Martha , Ettinger de Cuba Stephanie , Raifman Julia , Shafer Paul
Published: October 2022

Importance

Advance Child Tax Credit (CTC) monthly payments administered to more than 35 million households with children in the US between July and December 2021 were associated with a substantial decrease in food insufficiency. These monthly payments expired in January 2022 after Congress failed to extend the policy, and the subsequent impact on food insufficiency is currently unknown.

Objective

To assess whether the expiration of monthly CTC payments in January 2022 was associated with changes in food insufficiency in US households with children.

Design, Setting, and Participants

This study used repeated cross-sectional, nationally representative data from multiple waves of the Household Pulse Survey, conducted by the US Census Bureau. Online data collection occurred from July 21, 2021, to July 11, 2022, and data analysis was performed in July 2022.

Exposures

The first missed advance CTC payment on January 15, 2022.

Main Outcomes and Measures

The main outcome was unadjusted prevalence of household food insufficiency. Event study specification was used to estimate the association between the expiration of the CTC payments and household food insufficiency with the exposure of being in a household with children present.

Results

The sample (592 044 respondents, representing households with and without children, for a weighted population size of 123 350 770 individuals) was majority female (362 286 individuals [51.3%]) and non-Hispanic White (425 497 individuals [62.2%]), and a plurality of respondents (248 828 [48.3%]) were aged 25 to 44 years at the time of the survey. During the survey wave just before CTC expiration (reference wave, December 29, 2021, to January 10, 2022), unadjusted household food insufficiency was 12.7% among households with children. In late January and early February 2022, following the first missed CTC monthly payment, 13.6% of households with children reported food insufficiency, increasing to 16.0% by late June and early July 2022. The event study specification estimated a 3.2 percentage point increase (95% CI, 1.4-5.0 percentage points; P < .001) in food insufficiency by the most recent wave available after the first missed CTC payment (June 29 to July 11, 2022) among households with children compared with the reference wave, a 25% increase.

Conclusions and Relevance

The findings of this study suggest that there was an increase in food insufficiency among households with children after they stopped receiving monthly CTC payments. Given the well-documented associations between inability to afford food and poor health outcomes across the life span, Congress should consider swift action to reinstate this policy.
Chromosomal Aberrations in Cancer
Authors: McNerney Megan E. , Rosenberg Ari J. , Le Beau Michelle M.
Published: October 2022

Overview

The malignant cells of most patients who have leukemia, lymphoma, or a solid tumor have acquired clonal chromosomal abnormalities, the identification of which can aid in establishing the correct diagnosis and prognosis, and in the selection of therapy. Today, our arsenal of approaches to characterize an individual's malignant disease combines pathologic evaluation, cytogenetic analysis, and molecular studies. The advent of high‐throughput methods, such as next‐generation sequencing, capable of surveying the entire genome or large panels of cancer‐related genes presents new options for a revolutionary change in the way we diagnose, characterize, and treat cancer. The vision for the future entails an integrated molecular profile, i.e., chromosomal pattern, gene/miRNA expression, DNA methylation/epigenomic pattern, gene mutation status, pharmacogenomic profile, and chemosensitivity of each patient's tumor, as well as predisposition to disease, facilitating the development of an individualized treatment plan with decreased toxicities and prolonged survival.
Aberrant Signaling Pathways in Cancer
Authors: Grumolato Luca , Aaronson Stuart A.
Published: October 2022

Overview

Most, if not all, human cancers harbor aberrant activation of one or several signaling pathways, contributing to tumor initiation and/or progression. In this article, we describe how growth factors signal to receptors with intrinsic tyrosine kinase activity to promote cell proliferation and survival, largely through activation of the phosphatidylinositol‐3′‐kinase(PI‐3‐K)/Akt and Ras/MAPK pathways. Using different paradigmatic examples of oncogenic alterations in growth factor signaling, we discuss functional implications and relevance of these pathways for human cancer. General cell signaling principles in both normal and tumor cells will be addressed, and we briefly discuss how the initiation and progression of specific cancer types can be affected by the deregulation of certain other pathways.

Finally, we discuss the concepts of oncogene addiction and targeted therapy and provide a few representative examples to illustrate how increased understanding of the mechanisms underlying signaling pathway aberrations in cancer has been translated to the clinic.
Differentiation Therapy
Authors: Chen Sai‐Juan , Yan Xiao‐Jing , Zhou Guang‐Biao , Chen Zhu
Published: October 2022

Overview

Abnormal differentiation is one of the main features of human cancers, especially in hematological malignancies. Many aberrant genetic and epigenetic factors have been shown to disrupt the regulation of cell differentiation in a variety of cancers and play an important role in oncogenesis. Differentiation therapy refers to the application of therapeutic agents selectively targeting the key molecules involved in the process of cell differentiation, leading to the restoration of normal cellular homeostasis and the eventual clearance of cancer cells. Over the past four decades, investigations of the molecular mechanisms underlying cancer cell differentiation arrest or blockage have allowed the identification of an array of drug targets. On the other hand, many physiological or pharmacological agents have been tested using
in vitro
and
in vivo
systems as the inducers of differentiation and maturation of cancer cells. The translational research in this field has gradually turned the differentiation therapy from a concept to clinical practices. The most successful model of cancer differentiation therapy is the development of synergistic targeted therapy for acute promyelocytic leukemia (APL) with all‐trans‐retinoic acid (ATRA) and arsenic trioxide (ATO). This article discusses the basic theories of differentiation therapy and the clinical achievements of this therapeutic approach.
Cancer Cell Immortality: Targeting Telomerase and Telomeres
Authors: Mender Ilgen , Dikmen Zeliha G. , Shay Jerry W.
Published: October 2022

Overview

Finding specific targeted agents for cancer therapy remains a challenge. One of the hallmarks of cancer is the limitless proliferation (immortalization) of cancer cells, which correlates with the activation of the ribonucleoprotein enzyme complex called telomerase. Since 85–90% of primary human cancers express telomerase activity, while most normal cells do not, telomerase is a unique and almost universal therapeutic target for cancer. Although there have been several approaches developed for telomerase targeted therapies, there is still no successful therapeutic agent that has been approved. This article reviews the different approaches to target telomerase and summarizes preclinical and clinical results.
Statistical Innovations in Cancer Research
Authors: Lee J. Jack , Berry Donald A.
Published: October 2022

Overview

Cancer research is rapidly changing, with fast‐growing numbers of possible cancer targets and drugs to investigate and no end in sight. Advances in genomics, proteomics, epigenetics, and immune oncology provide remarkably detailed profiles of each patient's tumor and its microenvironment and, as a result, allow science to consider each patient as unique, with the goal of delivering individualized precision medicine. The low success rates of late‐phase clinical oncology trials, high costs, and long duration of bringing new drugs to market, however, have necessitated changes in the drug‐development process. Statistical innovations can help in the design and conduct of clinical trials to facilitate the discovery and validation of biomarkers and streamline the clinical trial process. The application of Bayesian statistics provides a sound theoretical foundation that can encourage the development of adaptive designs to improve trial flexibility and efficiency, while maintaining desirable statistical‐operating characteristics.