bluuebunny/crossref_metadata_2025 huggingface dataset:
The Interaction Between Nitrogen Supply and Light Quality Modulates Plant Growth and Resource Allocation
Authors: Liang Ying , Cossani C. Mariano , Sadras Victor O. , Yang Qichang , Wang Zheng
Published: May 2022

Nitrogen availability and light quality affect plant resource allocation, but their interaction is poorly understood. Herein, we analyzed the growth and allocation of dry matter and nitrogen using lettuce (Lactuca sativa L.) as a plant model in a factorial experiment combining three light regimes (100% red light, R; 50% red light + 50% blue light, RB; 100% blue light, B) and two nitrogen rates (low, 0.1 mM N; high, 10 mM N). Red light increased shoot dry weight in relation to both B and RB irrespective of nitrogen supply. Blue light favored root growth under low nitrogen. Allometric analysis showed lower allocation to leaf in response to blue light under low nitrogen and similar leaf allocation under high nitrogen. A difference in allometric slopes between low nitrogen and high nitrogen in treatments with blue light reflected a strong interaction effect on root-to-shoot biomass allocation. Shoot nitrate concentration increased with light exposure up to 14 h in both nitrogen treatments, was higher under blue light with high nitrogen, and varied little with light quality under low nitrogen. Shoot nitrogen concentration, nitrogen nutrition index, and shoot NR activity increased in response to blue light. We conclude that the interaction between blue light and nitrogen supply modulates dry mass and nitrogen allocation between the shoot and root.
Seasonal Responses of Hydraulic Function and Carbon Dynamics in Spruce Seedlings to Continuous Drought
Authors: Han Yangang , Deng Jiaojiao , Zhou Wangming , Wang Qing-Wei , Yu Dapao
Published: May 2022

Drought is expected to increase in the frequency and duration associated with climate change. Although hydraulic function and carbon (C) storage have been widely recognized as key components to plant survival under a single drought, the physiological responses to continuous drought remain largely unknown, particularly for high northern temperate and boreal forests which are sensitive to water stress. In this study, we quantified the survival, growth, gas exchange, water relations, and nonstructural carbohydrates (NSCs) in 3-year-old Jezo spruce (Picea jezoensis) seedlings responding to continuous drought stress. Seedlings were maintained in drought conditions for 392 days, covering two growing and one dormant winter season. Seedlings subjected to drought showed a significant decrease in net photosynthesis rate (Anet) and stomatal conductance (gs) in both growing seasons, and biomass in the second growing season. The seedling mortality continuously increased to 35.6% at the experimental end. Notably, responses of C storage and leaf water potential to drought varied greatly depending on seasons. Living seedlings exposed to drought and control treatments had similar NSC concentrations in both growing seasons. However, seedlings with concentrations of both the soluble sugars and starch less than 1% in root died in the winter dormant season. In the second growing season, compared with the control treatment, droughted seedlings had significantly lower leaf water potential and stem wood-specific hydraulic conductivity (Kw). Meanwhile, the leaf predawn water potential did not recover overnight. These suggest that C starvation might be an important reason for seedlings that died in the winter dormant season, while in the growing season drought may limit seedling survival and growth through inducing hydraulic failure. Such seasonal dependence in hydraulic dysfunction and C depletion may lead to higher mortality in spruce forests facing extended drought duration expected in the future.
Identification, Characterization and Function of Orphan Genes Among the Current Cucurbitaceae Genomes
Authors: Ma Dongna , Lai Zhengfeng , Ding Qiansu , Zhang Kun , Chang Kaizhen , Li Shuhao , Zhao Zhizhu , Zhong Fenglin
Published: May 2022

Orphan genes (OGs) that are missing identifiable homologs in other lineages may potentially make contributions to a variety of biological functions. The Cucurbitaceae family consists of a wide range of fruit crops of worldwide or local economic significance. To date, very few functional mechanisms of OGs in Cucurbitaceae are known. In this study, we systematically identified the OGs of eight Cucurbitaceae species using a comparative genomics approach. The content of OGs varied widely among the eight Cucurbitaceae species, ranging from 1.63% in chayote to 16.55% in wax gourd. Genetic structure analysis showed that OGs have significantly shorter protein lengths and fewer exons in Cucurbitaceae. The subcellular localizations of OGs were basically the same, with only subtle differences. Except for aggregation in some chromosomal regions, the distribution density of OGs was higher near the telomeres and relatively evenly distributed on the chromosomes. Gene expression analysis revealed that OGs had less abundantly and highly tissue-specific expression. Interestingly, the largest proportion of these OGs was significantly more tissue-specific expressed in the flower than in other tissues, and more detectable expression was found in the male flower. Functional prediction of OGs showed that (1) 18 OGs associated with male sterility in watermelon; (2) 182 OGs associated with flower development in cucumber; (3) 51 OGs associated with environmental adaptation in watermelon; (4) 520 OGs may help with the large fruit size in wax gourd. Our results provide the molecular basis and research direction for some important mechanisms in Cucurbitaceae species and domesticated crops.
Application of Cerium Dioxide Nanoparticles and Chromium-Resistant Bacteria Reduced Chromium Toxicity in Sunflower Plants
Authors: Ma Jing , Alshaya Huda , Okla Mohammad K. , Alwasel Yasmeen A. , Chen Fu , Adrees Muhammad , Hussain Afzal , Hameed Salma , Shahid Munazzam Jawad
Published: May 2022

The continuous increase in the heavy metals concentration in the soil due to anthropogenic activities has become a global issue. The chromium, especially hexavalent chromium, is highly toxic for living organisms due to high mobility, solubility, and carcinogenic properties. Considering the beneficial role of nanoparticles and bacteria in alleviating the metal stress in plants, a study was carried out to evaluate the role of cerium dioxide (CeO2) nanoparticles (NPs) and Staphylococcus aureus in alleviating the chromium toxicity in sunflower plants. Sunflower plants grown in chromium (Cr) contaminated soil (0, 25, and 50 mg kg−1) were treated with CeO2 nanoparticles (0, 25, and 50 mg L−1) and S. aureus. The application of Cerium Dioxide Nanoparticles (CeO2 NPs) significantly improved plant growth and biomass production, reduced oxidative stress, and enhanced the enzymatic activities in the sunflower plant grown under chromium stress. The application of S. aureus further enhanced the beneficial role of nanoparticles in alleviating metal-induced toxicity. The maximum improvement was noted in plants treated with both nanoparticles and S. aureus. The augmented application of CeO2 NPs (50 mg l−1) at Cr 50 mg kg−1 increased the chl a contents from 1.2 to 2.0, chl b contents 0.5 to 0.8 and mg g−1 FW, and decreased the leakage of the electrolyte from 121 to 104%. The findings proved that the application of CeO2 nanoparticles and S. aureus could significantly ameliorate the metal-induced stress in sunflower plants. The findings from this study can provide new horizons for research in the application of nanoparticles in phytoremediation and bioremediation.
Noise, Fake News, and Tenacious Bayesians
Authors: Brody Dorje C.
Published: May 2022

A modeling framework, based on the theory of signal processing, for characterizing the dynamics of systems driven by the unraveling of information is outlined, and is applied to describe the process of decision making. The model input of this approach is the specification of the flow of information. This enables the representation of (i) reliable information, (ii) noise, and (iii) disinformation, in a unified framework. Because the approach is designed to characterize the dynamics of the behavior of people, it is possible to quantify the impact of information control, including those resulting from the dissemination of disinformation. It is shown that if a decision maker assigns an exceptionally high weight on one of the alternative realities, then under the Bayesian logic their perception hardly changes in time even if evidences presented indicate that this alternative corresponds to a false reality. Thus, confirmation bias need not be incompatible with Bayesian updating. By observing the role played by noise in other areas of natural sciences, where noise is used to excite the system away from false attractors, a new approach to tackle the dark forces of fake news is proposed.
The Impact of Academic Procrastination on Second Language Writing: The Mediating Role of L2 Writing Anxiety
Authors: Zhang Chen , Zhang Wenzhong
Published: May 2022

Recently, there has been a surge of interest in the exploration of psychological properties in a second language context. Considerable literature has grown up around the influence of these psychological properties on L2 writing specifically. However, the impact of academic procrastination, which is an important psychological property, has been understudied and it remains unclear how affective factors in L2 might play a role in the above potential influence on L2 writing. Therefore, the current study explored the impact of academic procrastination on L2 writing and examined the mediating role of L2 writing anxiety, by adopting text readability as an innovative approach to assessing L2 writing performance. Participants were 55 Chinese speakers of L2 English. By utilizing the collected questionnaire data and the readability indicators of the L2 writing task, the current research conducted correlation analysis, regression analysis, and structural equation modeling analysis. The results revealed that academic procrastination had a significant negative impact on the readability indicator of Flesch-Kincaid Grade Level in L2 writing. L2 writing anxiety played a complete mediating role in the impact. Academic procrastination can significantly affect Flesch-Kincaid Grade Level of L2 writing indirectly through L2 writing anxiety. Pedagogical implications and future studies were discussed.
Design of Aging Smart Home Products Based on Radial Basis Function Speech Emotion Recognition
Authors: Wu Xu , Zhang Qian
Published: May 2022

The rapid development of computer technology and artificial intelligence is affecting people’s daily lives, where language is the most common way of communication in people’s daily life. To apply the emotion information contained in voice signals to artificial intelligence products after analysis, this article proposes a design based on voice emotion recognition for aging intelligent home products with RBF. The authors first aimed at a smart home design, and based on the problem of weak adaptability and learning ability of the aging population, a speech emotion recognition method based on a hybrid model of Hidden Markov/Radial Basis Function Neural Network (HMM/RBF) is proposed. This method combines the strong dynamic timing modeling capabilities of the HMM model and the strong classification decision-making ability of the RBF model, and by combining the two models, the speech emotion recognition rate is greatly improved. Furthermore, by introducing the concept of the dynamic optimal learning rate, the convergence speed of the network is reduced to 40.25s and the operation efficiency is optimized. Matlab’s simulation tests show that the recognition speed of the HMM/RBF hybrid model is 9.82–12.28% higher than that of the HMM model and the RBF model alone, confirming the accuracy and superiority of the algorithm and model.
Feasibility of an Exercise and CBT Intervention for Treatment of Depression: A Pilot Randomized Controlled Trial
Authors: Meyer Jacob D. , Perkins Seana L. , Brower Cassandra S. , Lansing Jeni E. , Slocum Julia A. , Thomas Emily B. K. , Murray Thomas A. , Lee Duck-chul , Wade Nathaniel G.
Published: May 2022

Depression (DEP) is prevalent and current treatments are ineffective for many people. This pilot study's purpose was to assess the feasibility, acceptability, and plausible efficacy of an 8-week intervention employing 30 min of prescribed moderate intensity exercise (“ActiveCBT”) compared to 30 min of usual activities (“CalmCBT”) immediately prior to weekly online CBT sessions. Ten adults with DSM-5-diagnosed current DEP were randomized to groups and completed: an intake assessment, eight weekly CBT sessions, final assessment, and 3-month follow-up. ActiveCBT participants were prescribed 30-min of moderate exercise immediately prior to each standardized 50-min CBT session. CalmCBT participants continued with normal activities for 30 min before therapy. Questionnaires regarding DEP symptom severity (Patient Health Questionnaire-9 [PHQ-9]), between-session effectiveness (Behavioral Activation for Depression Survey [BADS], Automatic Thoughts Questionnaire [ATQ]), in-session effectiveness (Working Alliance Inventory-Short Revised [WAI]), and state anhedonia (Dimension Analog Rating Scale [DARS], Visual Analog Scale [VAS]; assessed 3 times: before Active/Calm condition, after, and after therapy) were completed each week. Therapy fidelity ratings were independently coded via a standardized codebook. The Structured Clinical Interview for DSM-5 (SCID) and Hamilton Rating Scale for Depression (HAMD) were used to assess DEP at intake, final, and 3-month follow-up. We found strong feasibility and acceptability (100% adherence, 100% retention at final visit, 74.6% therapy fidelity, and high patient satisfaction ratings). Differences between groups favoring ActiveCBT in anhedonia (DARS, Hedges' g = 0.92; VAS, g = 3.16), within- (WAI, g = 0.1.10), and between-session effectiveness (ATQ g = −0.65; BADS g = −1.40), suggest plausible efficacy of ActiveCBT for enhancing CBT. DEP rates were reduced in both groups from baseline to final (60% MDD SCID remission) and at follow up (Active: 40%; Calm: 25%). Larger and potentially quicker symptom improvement was found favoring the Active condition to the final visit (HAMD, between-group changes g = −1.33; PHQ-9, g = −0.62), with small differences remaining at follow-up (HAMD, g = −0.45; PHQ-9, g = −0.19). Exercise priming appears acceptable and plausibly efficacious for enhancing mechanisms of CBT and overall outcomes, though the present small sample precludes efficacy determinations. It appears feasible to conduct a randomized controlled trial comparing ActiveCBT to CalmCBT. Future trials evaluating this potentially promising treatment approach and mediating mechanisms are warranted.
Psychometric Properties of the Stress and Anxiety to Viral Epidemics-6 Items (SAVE-6) Scale for High School Students During the COVID-19 Pandemic
Authors: Lee Taeyeop , Ahmed Oli , Akça Ömer Faruk , Chung Seockhoon
Published: May 2022

Objectives

Owing to the COVID-19 pandemic, high school students have experienced a sudden change of school environment, which may result in difficulties related to mental health. The aim of this study is to estimate the reliability and validity of the Stress and Anxiety to Viral Epidemics-6 Items (SAVE-6) scale among high school students.

Methods

A cross-sectional online survey was conducted among 300 high school students. The following scales were administered: the SAVE-6, Generalized Anxiety Disorder-7 Items (GAD-7), and Patient Health Questionnaire-9 Items (PHQ-9). Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted, and the psychometric properties of the SAVE-6 were assessed.

Results

The results of the CFA indicated good model fit for the SAVE-6 scale among high school students (χ2/df = 0.485, CFI = 1.000, TLI = 1.010, RMSEA < 0.001, and SRMR = 0.029). In addition, the SAVE-6 scale demonstrated good reliability (Cronbach’s alpha = 0.844, McDonald’s Omega = 0.848, and split-half reliability = 0.883). The appropriate cut-off score for the SAVE-6 scale was estimated as ≥15, which corresponds to a mild level of anxiety as assessed by the GAD-7 (≥5).

Conclusion

The SAVE-6 scale was found to be reliable and valid, and can be used as a tool to assess the stress and anxiety of high school students during the COVID-19 pandemic.
Periocular Skin Warming Promotes Sleep Onset Through Heat Dissipation From Distal Skin in Patients With Insomnia Disorder
Authors: Ichiba Tomohisa , Kawamura Aoi , Nagao Kentaro , Kurumai Yuichi , Fujii Akio , Yoshimura Atsushi , Yoshiike Takuya , Kuriyama Kenichi
Published: May 2022

Study Objectives

Periocular skin warming before bedtime has been demonstrated to improve subjective sleep initiation in healthy adults with sleep difficulties scored six or higher in the Pittsburgh Sleep Questionnaire Index. This study aimed to investigate the effects of periocular skin warming on sleep initiation and thermoregulation processes in patients with insomnia disorder.

Methods

Participants included those with sleep difficulty (n = 22) and those with insomnia disorder (n = 16). Individuals from both groups were assessed at baseline (habitual sleep-wake schedule) and after two intervention conditions (use of a warming eye mask or a sham eye mask before habitual bedtime). The subjective and electroencephalographic sleep onset latency, along with proximal and distal skin temperature after periocular skin warming, were evaluated.

Results

Periocular skin warming reduced objective sleep onset latency in independently of the group. Foot temperature and foot-proximal temperature gradient after getting into bed increased with periocular skin warming in independently of the group. However, the increase in hand temperature was observed only in the insomnia disorder group. Periocular skin warming also increased the normalized high frequency component of heart rate variability in independently of the group. The reduction of objective sleep onset latency was strongly associated with heat dissipation from the foot skin region.

Conclusion

These results suggest that periocular skin warming promotes sleep initiation by enhancing heat dissipation from the distal skin regions in individuals with sleep difficulty and insomnia disorder. Periocular skin warming could thus be a novel non-pharmacological therapy for insomnia disorder.
Prevalence and Factors Associated With Suicidal Ideation Among Adult Eritrean Refugees in Northern Ethiopia
Authors: Gebremeskel Teferi Gebru , Berhe Mulaw , Tesfahunegn Tadis Brhane , Gesesew Hailay Abrha , Ward Paul R.
Published: May 2022

Background

The present study assessed the prevalence of and factor associated with suicidal ideations among adult Eritrean refugees in Tigray, Ethiopia.

Methods

A community-based cross-sectional study was carried out among 400 adult refugees living in the Mai-Aini refugee camp in Tigray, Northern Ethiopia from September 2019 to May 2020. The response variable was suicidal ideation and was measured using World Mental Health (WMH) Survey Initiative Version of the World Health Organization Composite International Diagnostic Interview. We applied bivariate and multivariate logistic regression to determine predictors for suicide ideations. Odds ratios and p-values were determined to check the associations between variables, and a p-value <0.05 was considered as a cut-off for statistical significance.

Results

The prevalence of suicidal ideations was 20.5% (95% CI: 16.4%, 24.5%). Having previous history of trauma [AOR = 2.3, 95% CI: 1.4, 4.5], a history of chronic illness [AOR = 2.9, 95% CI: 1.3, 6.5], a family history of mental disorder [AOR = 3.08, 95% CI: 1.3, 7.06], and history of post-traumatic stress disorder [AOR = 5.7, 95% CI: 2.8, 11.5] were significantly associated with suicidal ideations.

Conclusions

This study showed that during the stay in the refugee camp, there was a high prevalence of suicide ideations compared to the prevalence of suicide ideations among the general populations of Ethiopia, Europe, and China, and the lifetime pooled prevalence across 17 countries. Having previous history of trauma, a history of chronic illness, a family history of mental disorder, and history of post-traumatic stress disorder were the factors statistically associated with the suicidal ideation.
Financial Budgets of Technology-Based SMEs From the Perspective of Sustainability and Big Data
Authors: Zhang Guobiao , Wang Tao
Published: May 2022

In this contemporary world, the words data and sustainability play a crucial role in determining the financial budgets of small and medium-sized enterprises (SMEs). Usually, it is stated that the survival of small and medium-sized enterprises (SMEs) is directly proportional to the growth and sustainability factor of the nation. The economic sustainability of a nation is dependent on appropriate functioning of SMEs. Any kind of direct impact on the working of SMEs will have its impact on the whole economy of a nation. There are different factors such as lack of financial capacity, low market demands, restrictions with regard to the capital, and barriers in the supply chain that affect the sustainability of SMEs worldwide. Nevertheless, small, and medium sized enterprises around the world are greatly investing on skills, innovation, and other capital related resources to mark up the demands of the external market. The main objective of this study is to examine the financial budgets of technology-based SMEs from the perspective of sustainability and big data. For this, the study collects data through a questionnaire from 1,800 Small and Medium Sized Enterprises. Based on a detailed and careful examination of the data, only 1,400 of the responses received were considered valid (79.75%). To test the hypothesis stated, the study employs structural equation modeling. This will help the researcher to examine the direct effect of financial budget and technology adaption of SMEs from the perspective of sustainability and big data. Results of the study stated that SMEs sustainability and big data are directly and positively related to the financial budget planning of technology-based SMEs. The study also found that big data plays an important role in the businesses, specifically for their own growth.
Effects of Family Doctor Contract Services on the Health-Related Quality of Life Among Individuals With Diabetes in China: Evidence From the CHARLS
Authors: Wang Lingjie , Liu Wenbin
Published: May 2022

Background

Family doctor contract services (FDCS) has played a key role in diabetes management in China since 2016. The influence of FDCS on the physiological indexes of individuals with diabetes has been examined. However, little attention has been paid to its effect on the Health-Related Quality of Life (HRQoL). This study aims to fill this knowledge gap by evaluating the effect of FDCS on the HRQoL of individuals with diabetes.

Methods

We identified 382 individuals with diabetes receiving all follow-up surveys in 2013, 2015, and 2018 from the China Health and Retirement Longitudinal Study (CHARLS). The HRQoL of the included individuals was estimated using results from the Short Form 36 (SF-36) questionnaire. The propensity score matching with the difference-in-differences (PSM-DID) approach was applied to quantify the effect of FDCS on the HRQoL among individuals with diabetes. A robust test was performed by setting the 2015 data as the treatment group for the placebo test.

Results

The mean score of role-emotional (RE) increased from 54.25 to 61.63 among those who signed up to receive FDCS, while the corresponding score decreased from 57.77 to 51.04 among those who did not receive FDCS. Results from the regression analysis indicated that the use of FDCS was associated with significant improvement in RE (+14.10, p = 0.04) among individuals with diabetes. We did not find a statistically meaningful association between the FDCS and any of the other HRQoL domains: physical functioning (PF), role-physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), and mental health (MH), respectively. The robustness analysis of the model indicated that the results were robust.

Conclusion

The FDCS for diabetes in China was associated with a significant improvement in RE. Due to a limited time since the launch of FDCS (i.e., 2016), the recipient's physical health did not show marked improvement. In the future, FDCS should pay more attention to the physiological health of individuals with diabetes. Moreover, psychological services also need to be maintained and not slackened. At the same time, it is strongly recommended to pay more attention to the HRQoL of individuals with diabetes and more comprehensive health.
The Impact of Dependency Burden on Urban Household Health Expenditure and Its Regional Heterogeneity in China: Based on Quantile Regression Method
Authors: Xu Xiaocang , Wang Qingqing , Li Chang
Published: May 2022

Background

The aging population has led to a growing health expenditure burden. According to the National Bureau of Statistics of China, the old-age dependency ratio rose from 10.7% in 2003 to 17.8% in 2019, and health expenditure increased from 658.410 billion yuan in 2003 to 5812.191 billion yuan in 2019 in China.

Methods

This paper utilizes the quantile regression method to discuss the influencing factors of health expenditure in urban China based on the China Household Finance Survey (CHFS), especially dependency burden. Moreover, its regional heterogeneity is also compared.

Results

The old-age dependency ratio, age, family size, self-rated health status, and income significantly impact the health expenditure of urban families in the quantile regression of the national sample. Dependency burden and other variables on urban household health expenditure have great regional heterogeneity. The relationship between urban health expenditure and residential areas in western China is more stable than that in eastern and central China.

Discussion

Government should improve the healthcare system suitable for the older adult population as soon as possible. The government of western China should pay more attention to the introduction of professional medical talents and the configuration of precision medical equipment to improve the health system in western China.
High-Risk Preterm Infant Born to a Mother With COVID-19: A Case Report
Authors: Formiga Cibelle Kayenne Martins Roberto , Veloso Aline Helena Nascimento , Fernandes Kathlen Terezinha Montes Soares , Guimarães Layra Alves , Avelar Marla Moreira , Medeiros Maja
Published: May 2022

The COVID-19 pandemic raises concerns about risks for pregnant women and fetuses, considering factors such as vertical transmission and neonatal alterations caused by maternal infection. Despite this, neuropsychomotor and functional complications in infants delivered by mothers with COVID-19 are still little studied. Thus, we aimed to describe the health history and development based on ICF (International Classification of Functioning, Disability and Health) components of a high-risk preterm infant born to a mother hospitalized due to COVID-19 complications. This case report was based on medical records, developmental assessments, and maternal reports. The infant was born at 30 weeks and 3 days, weighing 1,300 g, measuring 40 cm, and with Apgar scores of 2, 5, 6, and 7. COVID-19 test was negative 1 and 72 h after birth. Moreover, the infant had cardiorespiratory complications and hyperechogenicity of the periventricular white matter. The infant presented speech and language delays during follow-up, but neuromotor development occurred according to age. The health care and follow-up provided helped the development of resilience mechanisms by the infant and family to overcome adversities in the prenatal, perinatal, and neonatal periods. The assessments based on ICF components can contribute to future studies on this topic.
Controlling the Stage: A High-Level Control System for Virtual Audiences in Virtual Reality
Authors: Glémarec Yann , Lugrin Jean-Luc , Bosser Anne-Gwenn , Buche Cédric , Latoschik Marc Erich
Published: May 2022

This article presents a novel method for controlling a virtual audience system (VAS) in Virtual Reality (VR) application, called STAGE, which has been originally designed for supervised public speaking training in university seminars dedicated to the preparation and delivery of scientific talks. We are interested in creating pedagogicalnarratives: narratives encompass affective phenomenon and rather than organizing events changing the course of a training scenario, pedagogical plans using our system focus on organizing the affects it arouses for the trainees. Efficiently controlling a virtual audience towards a specific training objective while evaluating the speaker’s performance presents a challenge for a seminar instructor: the high level of cognitive and physical demands required to be able to control the virtual audience, whilst evaluating speaker’s performance, adjusting and allowing it to quickly react to the user’s behaviors and interactions. It is indeed a critical limitation of a number of existing systems that they rely on a Wizard of Oz approach, where the tutor drives the audience in reaction to the user’s performance. We address this problem by integrating with a VAS a high-level control component for tutors, which allows using predefined audience behavior rules, defining custom ones, as well as intervening during run-time for finer control of the unfolding of the pedagogical plan. At its core, this component offers a tool to program, select, modify and monitor interactive training narratives using a high-level representation. The STAGE offers the following features: i) a high-level API to program pedagogical narratives focusing on a specific public speaking situation and training objectives, ii) an interactive visualization interface iii) computation and visualization of user metrics, iv) a semi-autonomous virtual audience composed of virtual spectators with automatic reactions to the speaker and surrounding spectators while following the pedagogical plan V) and the possibility for the instructor to embody a virtual spectator to ask questions or guide the speaker from within the Virtual Environment. We present here the design, and implementation of the tutoring system and its integration in STAGE, and discuss its reception by end-users.
Ten Years of Research on the Water-Energy-Food Nexus: An Analysis of Topics Evolution
Authors: Lazaro Lira Luz Benites , Bellezoni Rodrigo Augusto , Puppim de Oliveira Jose Antonio , Jacobi Pedro Roberto , Giatti Leandro Luiz
Published: May 2022

This study explores how the concept and research on the water-energy-food (WEF) nexus has evolved over time. The research uncovers the key terms underpinning the phenomenon, maps the interlinkages between WEF nexus topics, and provides an overview of the evolution of the concept of WEF nexus. We analyzed published academic literature from the Scopus database and performed both qualitative and quantitative analyses using Natural Language Processing method. The findings suggest that the nexus approach is increasingly evolving into an integrative concept, and has been incorporating new topics over time, resulting in different methods for WEF nexus research, with a focus on interdisciplinary and inter-sectoral analyses. Through the five periods outlined, we have identified the nexus approach debate focused on the following predominant topics: i) Trend 1 (2012–2016) debates on WEF nexus for water management and natural resource security, ii) Trend 2 (2017–2018) linkages between the nexus, the sustainable development goals and green economy, iii) Trend 3 (2019) WEF nexus governance and policy integration, iv) Trend 4 (2020) application of the nexus concept on different scales, including regions, countries, watersheds, urban areas as well as other components coupled to the WEF nexus, and, v) Trend 5 (2021) climate change and urban nexus challenges.
Seasonality in Environmental Conditions Drive Variation in Plankton Communities in a Shallow Tropical Lake
Authors: Kondowe Benjamin N. , Masese Frank O. , Raburu Phillip O. , Singini Wales , Sitati Augustine , Walumona Riziki Jacques
Published: May 2022

Factors influencing the spatio-temporal dynamics of plankton communities in small tropical lakes are not well-understood. This study assessed plankton communities in response to spatial (six sampling sites) and seasonal (wet vs. dry seasons) changes in environmental variables in Lake Kanyaboli, a small satellite lake on the northern shores of Lake Victoria, Kenya. Water quality variables, including pH, conductivity (EC), dissolved oxygen (DO), temperature, Secchi depth (SD), nitrates (NO3-), nitrites (NO2-), ammonium (NH4+), soluble reactive phosphorus (SRP), total nitrogen (TN), total phosphorus (TP), and chlorophyll-a(Chl-a), were monitored monthly at six sites spread throughout the lake for 1 year. Phytoplankton and zooplankton samples were collected and analyzed for taxon composition and abundance. Two-way ANOVA showed no significant interaction between site and season for all variables. Likewise, there were no significant spatial differences for all variables except Chl-a. At-test showed significant seasonal differences in SD, DO,NH4+,NO3-,NO2-, and TN. Thirty phytoplankton genera were identified belonging to Bacillariophyceae, Chlorophyceae, Cryptophyceae, Cyanophyceae, Euglenoidae, Trebouxiophyceae, and Zygnematophyceae, with Chlorophyceae being the most dominant (42.30%). Zooplankton comprised of 15 genera, belonging to Copepoda (55.4%), Rotifera (27.9%), and Cladocera (16.7%). Two-way ANOVA for plankton abundance showed no significant interaction between site and season, but there were significant differences in community composition between the wet and dry seasons. Canonical correspondence analysis identified water clarity (Secchi depth) and concentrations of dissolved fractions of nitrogen and phosphorus as the major water quality variables driving variation in the composition of plankton communities in the lake. This study showed that seasonality was a major driver of changes in plankton community composition between dry and wet seasons through changes in the concentrations of nutrients (NH4+,NO3-,NO2-, TN, and TP). Lake Kanyaboli's phytoplankton community indicated a non-equilibrial state, perhaps due to short residence times of water, especially during the wet season, and dense macrophytes fringing the lake that increase nutrient uptake and limit the dominance of select phytoplankton species. This study shows the importance of long-term studies covering dry and wet seasons to understand the dynamics of plankton communities and their drivers in small tropical waterbodies to inform management and conservation.
Fishing for Sociality: How What We See Helps us With Social Interactions
Authors: Nunes Ana Rita , Félix Ana S. , Oliveira Rui F.
Published: May 2022

Far in the distance, you see something moving...is it a woman? When you look closely, you recognize the motion pattern and body form: it is definitely your mother. As she approaches, you recognize her face and see that she is moving quickly; you can guess that she is worried because you are late for lunch! Humans can visually distinguish others, their emotions, and their intentions by looking at how they move and the shapes of their bodies. But individuals with social difficulties like autism struggle to get the same information from these visual cues. So, it is important for doctors and scientists to understand how the brain perceives this information. In our work, we studied small fish that rely on visual characteristics, the way we do, to recognize their fellows, and we explored how cues from movement and body shape help these fish to interact with others.
Top 100 Most-Cited Articles on Enhanced Recovery After Surgery: A Bibliometric Analysis and Visualized Study
Authors: He Liping , Lu Lulu , Su Shengjie , Lin Qiang , Sheng Chan
Published: May 2022

Background

The enhanced recovery after surgery (ERAS) protocol is widely implemented in surgeries, and this study aims to reveal the characteristics of the 100 most-cited original articles in the field of ERAS research.

Methods

The literature was retrieved in the Web of Science database, the 100 most-cited original articles were identified, and their characteristics were analyzed, including the trends of publications and citations; contributions from countries, institutions, and authors; co-cited authors and journals in the references; served surgeries, research endpoints, keywords; and the level of evidence.

Results

There was a rising trend in the yearly publications and citations. Denmark and the USA contributed the largest number of highly cited papers. The University of Copenhagen was the most influential institution. Kehlet, Henrik was the most influential author. The British Journal of Surgery was the most often published and cited journal. ERAS protocols were overwhelmingly implemented in colorectal surgeries. The most focused endpoints were “length of stay”, “complications”, and “readmission”. The most frequently used keywords were “fast track”, “length of stay”, and “laparoscopy”. The keyword “enhanced recovery after surgery” burst since 2012. More than half of the highly cited articles presented level IV evidence, but there was no correlation between citations (densities) and the levels of evidence.

Conclusions

The highly cited research overwhelming implemented ERAS in colorectal surgeries, the “length of stay” was the most focused element, and Kehlet, Henrik was the most influential researcher. Most of the highly cited ERAS had low levels of evidence, and the total number of citations was not relevant to the level of evidence. Therefore, studies with high levels of evidence are still required in the future.
Predictive Biomarkers for a Personalized Approach in Resectable Pancreatic Cancer
Authors: Merz Valeria , Mangiameli Domenico , Zecchetto Camilla , Quinzii Alberto , Pietrobono Silvia , Messina Carlo , Casalino Simona , Gaule Marina , Pesoni Camilla , Vitale Pasquale , Trentin Chiara , Frisinghelli Michela , Caffo Orazio , Melisi Davide
Published: May 2022

The mainstay treatment for patients with immediate resectable pancreatic cancer remains upfront surgery, which represents the only potentially curative strategy. Nevertheless, the majority of patients surgically resected for pancreatic cancer experiences disease relapse, even when a combination adjuvant therapy is offered. Therefore, aiming at improving disease free survival and overall survival of these patients, there is an increasing interest in evaluating the activity and efficacy of neoadjuvant and perioperative treatments. In this view, it is of utmost importance to find biomarkers able to select patients who may benefit from a preoperative therapy rather than upfront surgical resection. Defined genomic alterations and a dynamic inflammatory microenvironment are the major culprits for disease recurrence and resistance to chemotherapeutic treatments in pancreatic cancer patients. Signal transduction pathways or tumor immune microenvironment could predict early recurrence and response to chemotherapy. In the last decade, distinct molecular subtypes of pancreatic cancer have been described, laying the bases to a tailored therapeutic approach, started firstly in the treatment of advanced disease. Patients with homologous repair deficiency, in particular with mutant germline BRCA genes, represent the first subgroup demonstrating to benefit from specific therapies. A fraction of patients with pancreatic cancer could take advantage of genome sequencing with the aim of identifying possible targetable mutations. These genomic driven strategies could be even more relevant in a potentially curative setting. In this review, we outline putative predictive markers that could help in the next future in tailoring the best therapeutic strategy for pancreatic cancer patients with a potentially curable disease.
Neurosurgery for Optic Pathway Glioma: Optimizing Multidisciplinary Management
Authors: Samples Derek C. , Mulcahy Levy Jean M. , Hankinson Todd C.
Published: May 2022

Optic pathway glioma (OPG) comprises 10% of pediatric brain tumors and 40% of all pediatric low-grade gliomas (pLGGs). While generally considered benign pathologically, many require interventions with chemotherapy, radiation, or targeted therapies. Management has historically foregone tissue diagnosis given the classical clinical/radiographic presentation of these tumors, inability to safely remove the lesions surgically, and efficacy and safety of available chemotherapy options. Furthermore, when considering such aspects as their delicate location, the role of surgery continues to be heavily debated. More recently, however, a greater understanding of the genetic drivers of OPGs has made operative tissue sampling a critical step in management planning, specifically for patients without Neurofibromatosis, Type I (NF1). Given the need for long-term, complex management of pediatric OPGs, it is crucial that a multidisciplinary approach is employed, and the rapidly expanding role of molecular characterization be incorporated into their management.
A Quantitative Method for Intraoperative Evaluation of Distal Fibular Malrotation
Authors: Huang Hui , Li Zihua , Xiao Fajiao , Xia Jiang , Li Bing , Yu Tao , Zhao Youguang , Zhou Haichao , He Wenbao , Li Zhendong , Yang Yunfeng
Published: May 2022

Background

Due to the low sensitivity of commonly used radiographic parameters for the evaluation of rotational malreduction of the distal fibula under intraoperative fluoroscopy, a quantitative method is needed to make up for this defect.

Methods

A total of 96 sets of computed tomography images of normal ankles were imported into MIMICS to reconstruct 3D models. The fibula models were rotated along the longitudinal axis from 30 degrees of external rotation to 30 degrees of internal rotation. Virtual X-ray function in MIMICS was used to obtain radiographic images in mortise view. A line was drawn through the tip of the medial malleolus and parallel to the distal tibial plafond, the distances from the medial edge of the fibula to the lateral malleolar fossa cortex and from the medial edge of the fibula to the lateral edge of the fibula were measured on this line, and the ratio of them was calculated and marked as ratio α.

Results

The mean ratio α for normal ankles was 0.49 ± 0.06, while the 95% confidence interval was 0.48–0.50. The ratio α decreased when the fibula was externally rotated and increased when the fibula was internally rotated. The effects of different genders or different types on each group of data were compared, and the p values were all greater than 0.05.

Conclusions

This is a new method to quantitatively evaluate rotational malreduction of the distal fibula during operation. The ratio α can correspond to the rotation angle of the fibula. The larger the ratio α, the more the internal rotation of the fibula. Contrarily, the smaller the ratio α, the more the external rotation of the fibula. Making the ratio α close to 0.5 may be an intuitive approach that can be used intraoperatively.
Biomechanical Evaluation of Seven Fixation Methods for Sagittal Split Ramus Osteotomy with Four Advancement Levels by Finite Element Analysis
Authors: He Yu , Zhang Henglei , Qiao Jia , Fu Xi , Xu Shixing , Jin Qi , Liu Jianfeng , Chen Ying , Yu Bing , Niu Feng
Published: May 2022

Background

Mandibular sagittal split ramus osteotomy (SSRO) is a routine surgery to correct mandibular deformities, such as mandibular retrusion, protrusion, deficiency, and asymmetry. However, nonunion/malunion of the fragments and relapse caused by fixation failure after SSRO are major concerns. Rigid fixation to maintain postosteotomy segmental stabilization is critical for success. Additionally, understanding the biomechanical characteristics of different fixation methods in SSRO with large advancements is extremely important for clinical guidance. Therefore, the aim of the present study was to evaluate the biomechanical characteristics of different SSRO methods by finite element analysis.

Methods

SSRO finite element models with 5-, 10-, 15-, and 20-mm advancements were developed. Seven fixation methods, namely, two types of bicortical screws, single miniplate, dual miniplates, grid plate, dual L-shaped plates, and hybrid fixation, were positioned into the SSRO models. Molar and incisal biomechanical loads were applied to all models to simulate bite forces. We then investigated the immediate postoperative stability from four aspects, namely, the stability of the distal osteotomy segment, osteotomy regional stability, stress distribution on the mandible, and implant stress performance.

Results

The stability of the distal osteotomy segment and osteotomy region decreased when the advancement increased. All seven fixation methods displayed favorable biomechanical stability under minor advancement (5 mm). With large advancements, bicortical screws, dual miniplates, and grid plates provided better stability. The von Mises stress was concentrated around the screws close to the osteotomy region for the proximal segment for all fixation methods, and the von Mises stress on implants increased with larger advancements. With small advancements, five fixation methods endured tolerable maximum stresses of <880 MPa. A single miniplate and dual L-shaped plates generally suffered high stresses using larger advancements. The biomechanical characteristics were similar under molar and incisal loads.

Conclusions

The current study investigated the biomechanical properties of seven fixation devices after SSRO under molar and incisal loads. Generally, bicortical screws, grid plates, and dual miniplates provided better biomechanical stability using finite element analysis.
Anesthetic Effect of the Fascia Iliaca Compartment Block with Different Approaches on Total Hip Arthroplasty and Its Effect on Postoperative Cognitive Dysfunction and Inflammation
Authors: Feng Tengchen , Zhao Jibo , Wang Jiayi , Sun Xiaojia , Jia Tong , Li Fulong
Published: May 2022

Objective

The objective of this article is to make a comparison of the anesthetic effects of the inside and outside fascia iliaca compartment block (FICB) in total hip arthroplasty (THA) and to study the effect of the different approaches of the FICB on postoperative cognitive dysfunction (POCD) and serum inflammatory cytokines in THA patients.

Methods

A total of 60 patients who received THA treatment from January 2021 to December 2021 were divided into two groups, namely, Inside group (inside approach of the FICB) and Outside group (outside approach of the FICB), according to the different approaches of the FICB. Forty-eight hours after surgery, we compared the use of ropacaine dosage, visual analogue scale (VAS) score, the use of patient-controlled analgesia (PCA), mini-mental state examination (MMSE) score, the incidence of POCD, and the serum levels of IL-1, IL-6. Secondary indicators include surgical indicators and the quality of anesthesia cannula.

Results

The ratio of re-fix the catheter, intubation time, and the use of ropacaine dosage at 48 h after surgery in the Outside group were significantly higher than that in the Inside group (p < 0.05), while the depth of cannulation in the Outside group was significantly lower than that in the Inside group (p < 0.05). VAS scores were comparable between the Inside and the Outside groups, except at 24 h after surgery. The use of PCA from 24 to 48 h after surgery in the Outside group was significantly higher than that in the Inside group (p < 0.05). The MMSE score and the incidence of POCD in the Outside group were higher than that in the Inside group. At the same time, the serum IL-1β levels at 1 and 6 h after surgery and the serum IL-6 levels at 1, 6, 24, and 48 h after surgery in the Outside group were significantly higher than that in the Inside group (p < 0.05).

Conclusion

Compared with the outside approach of the FICB, the inside approach of the FICB has better anesthetic effect, better postoperative analgesia, fewer postoperative analgesics, lower incidence of POCD, and lower serum cytokines during the treatment of THA patients.