bluuebunny/crossref_metadata_2025 huggingface dataset:
The development of a pharmacist-led intravenous-to-oral antibiotic switching therapy notification system in Khon Kaen Hospital
Authors: Srisura Nissara , Kessomboon Nusaraporn , leechaipichikul Ancharee , Khummuang Thawatchai
Published: January 2024

Objective: This research was to develop a pharmacist-led
intravenous-to-oral antibiotic switching therapy notification system
through the Plan-Do-Study-Act (PDSA) concept. Method: The study was a
three-step action research. First, we performed a situation analysis and
developed a system with the PDSA concept. Third, we evaluated the
outcome before and after applying the system in two target groups: group
1 (physicians in Khon Kaen Hospital involved in the system development)
and group 2 (pneumonic patients admitted in two pediatric wards). The
system’s development was divided into two phases. In phase I, data was
collected from January to March 2020 before developing. In phase II,
after the system had been developed, data from September to November
2020 was collected. The development of the system was evaluated using
value-stream mapping (VSM), time measurement, the rate of switching
intravenous to oral, length of intravenous therapy, and length of stay
display using descriptive statistics (percentages). Results: Developing
the model system by increasing access to essential information and
integrating a drug information service technology on dispensing helped
reduce total process time from 95 minutes to 88 minutes and reduced
total lead time from 175 to 159 minutes before and after applying the
system. The overall time reduction was 16 minutes, which increased the
activity ratio between total lead time and process time from 54.28% to
55.34%. The development system also reduced the length of intravenous
therapy and length of stay. Conclusion: The PDSA concept allowed
step-by-step analysis, and identification of areas for improvement on
the workflow and dataflow. Integrating a drug information service
technology to rapidly screen patients who pass the criteria can help
reduce the time-consuming process. This system can be used to develop a
localized system and extend to the organization to reflect areas that
need to be improved, suggested in the form of policies.
A chromosome-level genome of the kuruma shrimp (Marsupenaeus japonicus) provides insights into its evolution and cold-resistance mechanism
Authors: Ren Xianyun , Lv Jianjian , Liu Meng , Wang Qiong , Shao Huixin , Liu Ping , Li Jian
Published: January 2024

Marsupenaeus japonicus is an important marine crustacean species.
However, a lack of genomic resources hinders the use of whole genome
sequencing to explore their genetic basis and molecular mechanisms for
genome-assisted breeding. Consequently, we determined the
chromosome-level genome of M. japonicus. In total, 478.42 Gb of genomic
sequencing data were obtained using the PacBio platform. A final genome
assembly of 1.54 Gb was generated with a contig N50 of 229.97 kb. The
266 Contigs were categorized into 42 chromosomes using high‐throughput
chromosome conformation capture (Hi-C) technology, with a scaffold N50
of 38.27 Mb, occupying 95.9% of the genome. We identified 24,317
protein-coding genes in the M. japonicus genome, among which annotation
was available for 23,986 genes relying on information regarding known
proteins in public databases. M. japonicus is commercially valuable
because of its coloration and capability for live transport. A gene
involved in heme oxygenase (decyclizing) activity and heme oxidation was
identified under positive selection in M. japonicas. The truncated
protein had an altered helical structure, which might be responsible for
resistance to low oxygen, and even the colorful shell of M. japonicus.
The high-quality genome assembly enabled the identification of genes
associated with cold-stress and cold tolerance in kuruma shrimp through
the comparison of eyestalk transcriptomes between the low temperature
stressed shrimp and normal temperature shrimp. The genome assembly
presented here could be useful in future studies to determine the
genetic changes underpinning the ecological traits of M. japonicus, and
provide insights for genome assisted breeding.
Ferroptosis activate retinoic acid inflammation ignite the development of Silicosis
Authors: LI XINGJIE , Tan Jinzhuo , wu renlan , Zhang Zongde
Published: January 2024

Lung cells damage caused by inhalation of silica and silicon crystals
leads to Silicosis. Retinoic acid is a mitogen in the development of
lung organs and exerts pleiotropic effects on immune reactions. How
retinoic acid signaling engaged in Silicosis remains unknown. We report
here that retinoic acid signaling in dendritic cells was activated in
silicosis lesions. SiO2 activates the retinoic acid signaling by
provoking ferroptosis. Ferroptosis trigger a downstream “retinoic acid
inflammation” characterized by upregulating cGAS-STING signaling genes
and inflammasome associated IL-1βand IL-1α. However, knockdown of
retinoic acid receptor α slightly mitigates ferroptosis-induced cell
death. Inhibition of ferroptosis in mice relieves silica-induced lung
inflammation and fibrosis. This cellular retinoic acid response may act
as a cytosolic adjuvant to promote extended and upgraded inflammation.
Our work unveils a mechanism by which retinoic acid reaction integrates
cGAS-STING and inflammasome signaling to sustain silica-induced
inflammation.
Exponential stability of second order time deleay semilinear systems with bilinear control
Authors: Harraki Imad El , Absessalam Kadrani , ESSAMET MAHMOUD
Published: January 2024

In this paper, we discuss the stabilization of a class of delayed
bilinear hyperbolic system. We focus on two cases: the case where the
delay occurs in the bilinear control and the case where the delay acts
on the state. First, we show existence results under certain assumptions
for the considered systems. Second, we design for each system a bilinear
control guaranteeing exponential stability under Lipschitz nonlinear
perturbation. For the first system, the proof of stability is based on
Lyapunov’s abstract functional, while for the second system we prove an
equivalence between the stabilization of the delayed system and the
observability of the corresponding undamped system. Examples that fall
within our abstract framework are presented.
Evaluating oil removal by amphiphilic cellulose acetate-MoS2 in a flow through reactor and artificial neural network
Authors: Thangavelu Kavitha , Zou Linda
Published: January 2024

The amphiphilic Janus-like CA-MoS2 fibrous sponges were synthesized and
employed to remove oil from wastewater. The efficiency of treating 100 L
of emulsion containing 10 mg/L of oil by CA-MoS2 fibrous sponge in a one
pass flow through reactor was examined under different flow rate, pH and
temperature conditions. The oil concentrations in the treated effluent
were all below the industrial discharge requirement of 5 mg/L. The spent
sponges were successfully regenerated and reused in multiple cycles. It
was found that the adsorption of oil followed the Langmuir adsorption
isotherm (R2 = 0.988) and pseudo-second-order kinetic (R2 = 0.995).
Artificial neural networking (ANN) was developed to optimized the oil
removal. The trained ANN was used to predict the oil removal of two new
conditions. This study provides the basis for the development of an
efficient material that can treat large volume of dilute oil containing
wastewater for water reuse.
Hypothesis Article: Exosomal miR-210-3p derived from atrial myocytes as a novel mechanism contribute to cardiac fibrosis in atrial fibrillation
Authors: Li Yue , Hao Hongting , yuan Yue , Yan Sen , Zhao Xinbo , Han Xuejie , Fang Ning , Zhang Yun , Dai Chenguang , Li Wenpeng , Yu Hui , Gao Yunlong , Wang Dingyu , Gao Qiang , Duan Yu
Published: January 2024

Cardiac fibrosis plays a critical role in the development of atrial
fibrillation (AF). However, the pathogenesis of atrial fibrosis remains
unclear. Recent studies suggest that exosomes mediated cellular
crosstalk leads to diverse cardiovascular diseases. The aim of our study
is to investigate the role of exosomal miR-210-3p derived from atrial
myocytes in promoting the proliferation and differentiation of atrial
fibroblasts and resulting in atrial fibrosis during AF. miRNAs
sequencing analysis revealed that miR-210-3p expression significantly
increased in exosomes of tachypacing atrial myocytes, and serum of AF
patients. In vitro, miR-210-3p inhibitor reversed tachypacing-induced
proliferation and collagen synthesis of atrial fibroblasts. miR-210-3p
KO could reduce the inducibility of AF and ameliorate atrial fibrosis
induced by Ang Ⅱ. mRNA sequencing and dual-luciferase reporter assay
proved that glycerol-3-phosphate dehydrogenase 1-like (GPD1L) is the
potential target gene of miR-210-3p. GPD1L regulated atrial fibrosis via
PI3K/AKT signaling pathway in vivo and in vitro. Besides, si-GPD1L
intensified atrial fibroblasts proliferation and these effects could be
reversed by PI3K inhibitor (LY294002). We demonstrate that atrial
myocytes derived exosomal miR-210-3p promoted the proliferation and
collagen synthesis via inhibiting GPD1L in atrial fibroblasts.
Preventing pathological crosstalk between atrial myocytes and
fibroblasts may as a novel target to improve atrial fibrosis in AF.
Museomic approaches to genotype historic Cinchona barks
Authors: Canales Nataly , Gardner Elliot , H. Tobias Gress , Walker Kim , Bieker Vanessa , Martin Michael , Nesbitt Mark , Antonelli Alexandre , Rønsted Nina , Barnes Christopher
Published: January 2024

Over the last few centuries, millions of plant specimens have
accumulated within herbaria and biocultural collections. These include
type specimens, used to define species, and populations that are rare,
extinct or difficult to access. They therefore represent a considerable
resource for a broad range of scientific uses. However, collections
degrade over time, and become increasingly difficult to characterise
their genetic signatures, even considering exponential advancements in
sequencing technologies. Here, we tested the genotyping performance on
highly degraded samples using a commonly used high-throughput sequencing
(HtS) technique, genome skimming, against a recent alternative target
capture kit, the universal set Angiosperm-353. We performed phylogenomic
analyses of modern leaf and historical barks of Cinchona, including 23
historical barks and six fresh leaf specimens. DNA within historical
barks is highly degraded, therefore a customised DNA extraction method
was developed before library preparation. We show that sample
degradation over time directly impacted the quantity and quality of the
data produced by both methodologies (in terms of reads mapped to the
references). However, we find that both approaches generate enough data
to infer phylogenetic relationships, even between highly degraded
specimens that are over 230 years old. Within historical barks, the
target capture kit is more advantageous than genome skimming in
profiling Cinchona species since it was possible to retrieve nuclear and
plastid data to infer phylogenies. This study showcases the value of
historical samples in genetic studies and paves the way for further
experiments across different taxonomic groups with varying levels of
genetic variation or hybridisation.
The high-level expression analysis of rhPA in the rhPA/gGH double-transgenic rabbits and its thrombolysis activity in vitro
Authors: Song Shaozheng , Luo Yaoling Yaoling , Li Dan , Yan Ying , Zhuang Qinmin , Ye Junsong Junsong , He Zhengyi
Published: January 2024

Abstract: 【Objective】In this study, the rhPA/gGH double transgenic
rabbits were constructed, and the expression level of rhPA,rabbit growth
and development features were analyzed, which might provide a new idea
for obtain rhPA high level expression transgenic animals.【Method】Two
rhPA transgenic rabbits fertilized eggs were microinjected with
linearized GH plasmid to obtain the rhPA/gGH rabbits.The integration of
rhPA/gGH gene was detected by PCR. The rhPA expression level in
transgenic rabbit milk was detected by ELISA and Western blotting,and
FAPA was performed to detect the in vitro thrombolytic activity of
rhPA.The body weight of transgenic rabbits at different growth stages
were measured to test the effect of gGH gene on rhPA/gGH double
transgenic rabbits growth and development .【Result】A total of 151 rhPA
transgenic rabbits fertilized eggs were obtained through superovulation,
125 of them were microinjected with linearized GH plasmid and
transplanted into 8 surrogate mother rabbits.Six surrogate mother
rabbits were pregnant, with a pregnancy rate of 75.0% (6/8)，16
rhPA/gGH gene double transgenic rabbits were identified by PCR (10♂,6♀).
The rhPA expression levels in rhPA single-transgenic rabbit whey were
0.27–0.63g/L, while the rhPA expression leves were 4.98-12.24 g/L in
the rhPA/gGH double-transgenic rabbits whey. The rhPA expression levels
of rhPA/gGH double-transgenic rabbit whey were significantly increased
by about 17.2–23.8 times, and had higher thrombolytic activity in
vitro. There was no significant difference in body weight between
rhPA/gGH double transgenic rabbits, rhPA single transgenic or
non-transgenic rabbits from birthday to 10 months
age(P>0.05). 【Conclusion】The rhPA/gGH double transgenic
rabbits were successfully constrected, which was proved that the
introduction of gGH gene could significantly increase the rhPA
expression level in the milk of transgenic rabbits and without affecting
the growth and development of transgenic rabbits, which laid a
foundation for the preparation of transgenic rabbits with higher
recombinant protein expression level in the future, and also provide new
ideas and new methods for the establishment of mammary gland bioreactor.
Novel Pathogenic Variants of TMPRSS6 Gene in a Girl with Iron Refractory Iron Deficiency Anemia (IRIDA)
Authors: Udomponglukkana Rawinun , Sasanakul Werasak , Tangbubpha Noppawan , Chuansumrit Ampaiwan , Tim-Aroon Thipwimol , Pongpitcha Pongpak , Sirachainan Nongnuch
Published: January 2024

Iron refractory iron deficiency anemia (IRIDA) is an autosomal recessive
disorder caused by mutations in the TMPRSS6 gene, which impairs iron
homeostasis. We report a 4-year-old girl presented with a one-year
history of IDA. Hemoglobin, transferrin saturation, and hepcidin levels
were 6.5 g/dL, 1.6%, and 112.17 ng/mL, respectively. High-dose oral
iron therapy partially corrected hemoglobin levels, and they declined
after decreasing or stopping iron therapy. Genetic analysis of the
TMPRSS6 gene identified compound heterozygotes of two novel pathogenic
variants of c.811C>T in exon 7 (p.R271X) and
c.1254C>G in exon 11 (p.Y418X). Her parents carried a
heterozygous mutation of each variant.
Charybdis japonica genome provides insights into desiccation adaptation and sex-determining region
Authors: Lou Fangrui , Gao Tianxiang , Liu Qi , Han Zhiqiang
Published: January 2024

Charybdis japonica predominantly inhabits the intertidal zones
and has high desiccation tolerance. We present the first
chromosome-level C. japonica genome, which contains 51
chromosomes, and the revised genome is 1431.02 Mb in length and has a
contig N50 size of 29.67 Mb. Among the contigs, 91.42% were anchored to
51 chromosomes. Additionally, 824.02 Mb repeat elements, 30,900 coding
genes, 474 miRNAs, 15,570 tRNAs, 309 rRNAs, and 157 miRNAs were
identified in the C. japonica genome. The whole-genome
resequencing data can contribute to the identification of sex-related
single-nucleotide polymorphisms and insertion–deletion mutations. The
0-10,120,000 bp of chromosome 37 is the sex-determining region of
C. japonica. Comparative genome analysis identified 1,138
C. japonica-specific gene families. Phylogenetic analysis showed
that C. japonica has a close relationship with Portunus
trituberculatus, which also belonged to family Portunidae, and
differentiated 42.1-135.5 million years ago. Demographic history
analysis suggested that the maximum effective population size of
C. japonica was maintained until 0.5×105 years ago. Relative
evolution rate showed that C. japonica evolved slower than
Daphnia magna, Penaeus vannamei, and P.
trituberculatus. Compared with other species, metabolism rate, oxygen
supply, oxidative stress, and various transporter-related genes were
expanded or underwent positive selection in C. japonica, which
might contribute to C. japonica’s ability to overcome diverse
stresses in drought environment. Decoding the present genome provides
valuable information for revealing the desiccation-adaptive and
sex-determining mechanisms of C. japonica and also enriches the
genetic information to explore the evolutionary history and
environmental adaptation strategies of other Portunidae crabs.
Avian species diversity in the southern Gulf of Lake Tana and head of the Blue Nile River, Ethiopia
Authors: Berhane Dessalegn , Abebaw Belaynesh , Wondie Ayalew , Kefyalew Tilahun
Published: January 2024

Avian study in the southern Gulf of Lake Tana and head of the Blue Nile
River, Ethiopia was conducted from June 2016 to April 2017 during the
wet and dry seasons to examine species composition, relative abundance,
and habitat association of birds. The study area was classified based on
its vegetation cover and composition and the point count method was used
to gather information about the occurrence of avian species and their
relative abundances. A total of 131 avian species belonging to 15 orders
and 53 families were identified. The wet and dry seasons data indicated
that 122 and 108 avian species, respectively, were recorded. Agapornis
tranta and Oriolus monachal are endemic birds of Ethiopia and Eritrea
that are occurring in the study area. Moreover, two Intra-African
migrant, Threskiornis aethiopicus and Milves migrans, and two Palearctic
migrant, Delichon urbicum and Motacilla flava were identified in the
area. The highest avian diversity was recorded in the Debremariam
wetland (H’=3.96), while the lowest was at the adjacent areas of Lake
Tana (H’=3.22). The relative abundance score showed that 54.8% of the
avian species were uncommon and there was a significant difference in
the relative abundance of birds between the wet and dry seasons
(p<0.05). Different anthropogenic activities and urbanization
are the main threats to the conservation of birds in the southern Gulf
of Lake Tana. Therefore, appropriate management actions should be
designed and implemented to ensure the conservation of birds in the Lake
and its adjacent habitats. Keywords: Blue Nile, endemic, Lake Tana,
species diversity, point count
The effects of virtual reality in maternity delivery: a systematic review and meta-analysis
Authors: xu nuo , Chen Sijing , Liu Yan , Jing Yuewen , Gu Ping
Published: January 2024

Background: As an emerging non-pharmacological method of analgesia,
there are no uniform conclusions on the effect of virtual reality (VR)
technology in labor. Objective: Exploring the effectiveness of VR
technology in maternal delivery. Search strategy: We searched Pubmed,
Embase, Web of Science, the Cochrane Library, CINAHL, China National
Knowledge Infrastructure, Wan-Fang database from building to November
17, 2021. Selection Criteria: Randomized controlled trials (RCTs) that
intervened the pregnant women aged 18-35 years with gestational
age>34 weeks and without complications with VR technology
were contained within this review. Data Collection and Analysis: Two
researchers completed the study selection, data extraction, and
assessment of study quality. MD or SMD used for quantitative data, and
RR (risk ratio) for qualitative data. Random-effects model and 95%
confidence interval (95% CI) were used. Main Results: 12 studies were
included. Using VR could relieve pain during labor (MD=-1.81, 95% CI
(-2.04, -1.57), P< 0.00001) and active period (SMD=-0.41, 95%
CI (-0.68, -0.14), P= 0.003), reduce anxiety (SMD=-1.39, 95% CI (-1.99,
-0.78), P< 0.00001) and improve satisfaction with delivery (RR
= 1.32; 95% CI (1.10, 1.59); P = 0.003), but the effect on the duration
of first (SMD=-1.12, 95% CI (-2.38, 0.13), P=0.08) and second
(SMD=-0.22, 95% CI (-0.67, 0.24), P=0.35) stage of labor was not
statistically significant. Conclusions: Compared with conventional care,
VR technology can relieve labor pain and anxiety and improve
satisfaction. However, extensive experimental validation is still
needed. Funding: None. Keywords: Virtual reality technology, delivery,
labor pain, anxiety, meta-analysis, systematic review
COVID-19 Therapeutic Misinformation and Toxicological Consequences
Authors: Amrollahi-Sharifabadi Mohammad
Published: January 2024

The new coronavirus pandemic alarmed the world. Misinformation regarding
prevention and treatment for safeguarding against this pandemic seemed
to be life-threatening along with the spreading pandemic. Public health
authorities in the world tried to battle this virtual virus by offering
true information and correcting misinformation. However, the public
misinformation through social media caused toxicological consequences in
some parts of the world which provoked awareness, response, and concern
of the public health authorities including the FDA and toxicology
community. On the other hand, finding new strategies for the prevention
and treatment of the coronavirus again stress the roles of public
education about true drug information. Hundreds of chemicals were/are
being tested to be prophylactic medications or healing drugs for the
coronavirus. Therefore, spread accurate information and edit
misinformation can be crucial. This essay is going to bring the
attention of misinformation regarding prevention and treatment for
safeguarding against the COVID-19 pandemic and its toxicological
consequences and the need for public education toward appropriate use of
therapies.
Prenatal Diagnosis of Heterotaxy Syndrome: A Case Report and Literature Review
Authors: Liu Chia-Chen , Chen Chia-Hui , Cheng Chih-Chien
Published: January 2024

Objective: We report on a fetus with left atrial isomerism and
structural anomalies compatible with heterotaxy syndrome but with a
normal karyotype. Case report: A 30-year-old healthy female
primigravida with no history of miscarriage or family genetic
abnormalities showed low risk for major chromosomal aneuploidies
(trisomy 21, 18, and 13) at the combined first-trimester screening.
Fetal ultrasound at the 20 gestational week
demonstrated left atrial isomerism, VSD (0.46 mm), morphological right
ventricle (left side) connecting to the aorta, morphological left
ventricle (right side) connecting to the pulmonary trunk, and
infracardiac and supracardiac total anomalous pulmonary venous return.
Cytogenetic analysis of amniotic fluid cells by routine karyotyping and
array comparative genomic hybridization (aCGH) revealed a normal female
fetus. The pregnancy was terminated before the 24th gestational week,
and autopsy was performed. Conclusion: Heterotaxy syndrome, a
rare congenital anomaly, can present with various clinical
manifestations but with a normal karyotype.
Towards Semi-Autonomous Robotic Arm Manipulation: Operator Intention Detection from Forces Feedback
Authors: Alharthi Abdullah
Published: February 2024

In harsh environments such as those found in nuclear facilities, the use of robotic systems is crucial for performing tasks that would otherwise require human intervention. This is done to minimize the risk of human exposure to dangerous levels of radiation, which can have severe consequences for health and even be fatal. However, the telemanipulation systems employed in these environments are becoming increasingly intricate, relying heavily on sophisticated control methods and local master devices. Consequently, the cognitive burden on operators during labour-intensive tasks is growing. To tackle this challenge, operator intention detection based on task learning can greatly enhance the performance of robotic tasks while reducing the reliance on human effort in teleoperation, particularly in a glovebox environment. By accurately predicting the operator’s intentions, the robot can carry out tasks more efficiently and effectively, with minimal input from the operator. In this regard, we propose the utilization of Convolutional Neural Networks, a machine learning approach, to learn and forecast the operator’s intentions using raw force feedback spatiotemporal data. Through our experimental study on glovebox tasks for nuclear applications, such as radiation survey and object grasping, we have achieved promising outcomes. Our approach holds the potential to enhance the safety and efficiency of robotic systems in harsh environments, thus diminishing the risk of human exposure to radiation while simultaneously improving the precision and speed of robotic operations.
Estimating the Ionospheric Induction Electric Field using Ground Magnetometers
Authors: Madelaire Michael , Laundal Karl , Hatch Spencer , Vanhamäki Heikki , Reistad Jone , Ohma Anders , Merkin Viacheslav , Lin Dong
Published: February 2024

The ionospheric convection electric field is often assumed to be a
potential field. This assumption is not always valid, especially when
the ionosphere changes on short time scales $T \lesssim
5$~min. We present a technique for estimating the
induction electric field using ground magnetometer measurements. The
technique is demonstrated on real and simulated data for sudden
increases in solar wind dynamic pressure of $\sim$1 and
10 nPa, respectively. For the real data, the ionospheric induction
electric field is 0.15$\pm$0.015 mV/m, and the
corresponding compressional flow is 2.5$\pm$0.3 m/s.
For the simulated data, the induction electric field and compressional
flow reach 3 mV/m and 50 m/s, respectively. The induction electric field
can locally constitute tens of percent of the total electric field.
Inclusion of the induction electric field increased the total Joule
heating by 2.4\%. Locally the Joule heating changed by
tens of percent. This corresponds to energy dissipation that is not
accounted for in existing models.
Simulating mixed-phase open cellular clouds observed during COMBLE: Evaluation of parameterized turbulence closure
Authors: Juliano Timothy W , Lackner Christian Philipp , Geerts Bart , Kosovic Branko , Xue Lulin , Wu Peng , Olson Joseph
Published: February 2024

Marine cold-air outbreaks, or CAOs, are airmass transformations whereby
relatively cold boundary layer (BL) air is transported over relatively
warm water. Such convectively-driven conditions are rather ubiquitous in
the high-latitudes, occurring most frequently during the winter and
spring. To more deeply understand BL and cloud properties during CAO
conditions, the Cold-Air Outbreaks in the Marine Boundary Layer
Experiment (COMBLE) took place from late 2019 into early 2020. During
COMBLE, the U.S. Department of Energy (DOE) first Atmospheric Radiation
Measurement Mobile Facility (AMF1) was deployed to Andenes, Norway, far
downstream (~1000 km) from the Arctic pack ice. This
study examines the two most intense CAOs sampled at the AMF1 site. The
observed BL structures are open cellular in nature with high
(~3-5 km) and cold (-30 to -50 oC) cloud tops, and they
often have pockets of high liquid water paths (LWPs; up to
~1000 g m-2) associated with strong updrafts and
enhanced turbulence. We use a high-resolution mesoscale model to explore
how well four different turbulence closure methods represent open
cellular cloud properties. After applying a radar simulator to the model
outputs for direct evaluation, we show that cloud top properties agree
well with AMF1 observations (within ~10%), but radar
reflectivity and LWP agreement is more variable. The
eddy-diffusivity/mass-flux approach produces the deepest cloud layer and
therefore the largest and most coherent cellular structures. Our results
suggest that the turbulent Prandtl number may play an important role for
the simulated BL and cloud properties.
Isotopic Fractionation During Sublimation of Low Porosity Ice
Authors: Bellagamba Anthony W , Berkelhamer Max , Steen-Larsen Hans Christian , Hamed Yasmeen , Pearce Kristen
Published: February 2024

The isotopic effects of sublimating ice is poorly understood and
disagreement from diverging results from studies spans decades. The core
question is whether sublimation occurs layer-by-layer with no
fractionation or whether diffusion within the ice and vapor-ice exchange
generate fractionation. Here, small ice spheres were suspended in an
unsaturated atmosphere and a Rayleigh distillation model was used to
estimate fractionation of the spheres. A small, yet statistically
significant and repeatable, fractionation (103lna18O of
~ -0.6‰ (ɑ = 0.999) and 103lna2H -3 to -6‰ (ɑ = 0.994 to
0.997 ) was observed, smaller than predicted for equilibrium
fractionation at this temperature and humidity. Assuming a modest
porosity of 0.0005%, porosity could sufficiently increase diffusivity
to explain the observed fractionation. The results help reconcile how
sublimation varies between experimental and observational studies where
uncontrolled porosity varies substantially across a continuum from
porous firn layers to low porosity ice deep in glaciers.
Analysis of Electron Distribution Functions using the Gaussian Mixture Model
Authors: Sanò Beniamino , Maes Nathan N. , Newman David L. , Goldman Martin V. , Valentini Francesco , Lapenta Giovanni
Published: February 2024

Velocity distribution functions (VDFs) measured by the Magnetospheric
Multiscale (MMS) mission are complex 3D datasets that can be represented
as a superposition of multiple beams (M. V. Goldman et al., 2020). A
recent work (Dupuis et al., 2020) proposed the use of the Gaussian
Mixture Model (GMM). Here we investigate the approach by considering
first synthetic distributions made by artificially creating beams of
either Maxwellian distributions or kappa distributions with varying
power law index. By varying the inter-beam average difference and the
beam standard deviation we evaluate the ability of the GMM in
recognizing correctly the beam. We then apply the method systematically
to MMS data in the tail and in the dayside. In this case, the data need
preparation before being processed by the GMM to account for the
specifics of the instrument and in particular the lack of data at low
energy and to account for the noise in the counts. The conclusion of the
analysis is that the GMM is capable of detecting the presence of
multiple beams when their distinction is significant. The GMM can define
reliably the complexity of a measured dataset in terms of the number of
optimal beams provided by information theory criteria. Visual inspection
confirms this automatic definition of complexity.
Machine Learning based Estimator for Ground Shaking Maps in South Iceland Seismic Zone (SISZ)
Authors: Monterrubio-Velasco Marisol , Blanco-Prieto Rut , Callaghan Scott , Modesto David , Puente Josep de la
Published: February 2024

Pre-print:
Ground Motion Shaking Predictions Based on Machine Learning and
Physics-based Simulations

Earthquakes constitute a major threat to human lives and infrastructure,
hence it is crucial to quickly assess the intensity of ground motions
after a major seismic event. Rapid estimation of the intensity of ground
vibrations is essential to assess the impact after a major earthquake
occurs.

The Machine Learning Estimator for Ground Shaking Maps (MLESmap)
introduces an innovative approach that harnesses the predictive
capabilities of Machine Learning (ML) algorithms, utilizing high-quality
physics-based seismic scenarios. MLESmap aims to provide ground
intensity measures within seconds following an earthquake. The inferred
information can produce shaking maps of the ground providing
quasi-real-time affectation information to help us explore uncertainties
quickly and reliably.

To develop the MLESmap technology, we used ground-motion simulations
generated by the CyberShake platform. Originally designed for Southern
California, this physics-based Probabilistic Seismic Hazard Methodology
was migrated to the South Iceland Seismic Zone recently.

Our methodology follows a three-step process: simulation, training, and
deployment. By employing this approach, we can generate the next
generation of ground shake maps, incorporating essential physical
information derived from wave propagation, such as directivity,
topography, and site effects. Remarkably, the evaluation times for
MLESmap are comparable to empirical Ground Motion Models, whereas the
predictive capacity of the former is superior for the Mw >
5 earthquakes.

In this work, we present the application of the MLESmap methodology in
South West Iceland.
Laser systems for detecting biological entities in premises with photovoltaic systems as the function of green building
Authors: Trifunovic-Dragisic Vesna , Despotovic Iva
Published: January 2024

Rodents cutting the installation system with their teeth were a frequent
issue with electric installation in the era of classical architecture.
However, contemporary architectural systems with photovoltaic sources of
energy, accompanied by premises' smart systems of information and energy
transfer, have microorganisms destroying the optical and other types of
installation. This work represents building systems of residential
premises with photovoltaic sources of energy which point out the segments of
urban areas jeopardized by the possible appearance of microorganisms.
Afterward, a review of laser techniques for the detection, identification,
and destruction of such microorganisms was given. It was concluded where to
direct the further laser system development to protect smart buildings
from biological contamination.
Clinical Outcome of Root Coverage Following the Treatment of Multiple Gingival Recession Defects Treated with Vista in Combination with PRF and Zuucchelli’s Technique: A Case Series
Authors: Kaur Navneet
Published: January 2024

Background: Mucogingival treatment for gingival recession coverage is very specific and is more predictable when done with a specific technique. Different surgical approaches should be focused more on the basis of their effectiveness, efficacy and efficiency meeting the needs of patient’s aesthetic and functional demand. Aim: The purpose of this case series is to combine the biological properties of PRF and compare both the techniques VISTA and Zucchelli’s to predict the clinical outcome of gingival recession coverage. The case series describe the treatment of gingival recession with bilateral Miller’s class I and II recession (RT1 and RT2) defects extend from canine to premolars by using Vestibular incision sub periosteal tunnel access (VISTA) technique and Zucchelli’s technique with PRF. Clinically gingival recession and width of keratinized gingiva was assessed at the follow up time interval 1 month and 3 months. Based on the clinical outcome, both VISTA and Zucchelli’s technique are reliable for the treatment of multiple gingiva recession defect. It also improves the root coverage, and gingival phenotype. The use of PRF with Zucchelli’s and VISTA technique is a substitute in terms of regeneration and enhanced wound healing process.
A Socio-Legal Intersectional Analysis of the Role of Technology in the Investigation of Conflict-Related Sexual and Gender-Based Violence
Authors:   , Egan Ulic
Published: February 2024

The role of technology, including the use of digital open sources, is rapidly expanding in international criminal investigations. Modern armed conflicts are being documented in a manner never before possible and the amount of relevant contemporaneous information available to investigators would have been inconceivable in the past. Access to technology further affords opportunities to those affected by conflict-related violence to better document and illuminate the crimes perpetrated against them. This new reality potentially provides possibilities to transform and democratize international criminal justice processes and help better secure accountability for atrocity crimes. However, the use of technologies may simultaneously inflict invisibilities and perpetuate bias, including regarding the investigation and documentation of sexual and gender based violence (SGBV). It is therefore crucial that international criminal investigators and prosecutors of SGBV atrocity crimes employ an ethical, comprehensive, and consistent methodological approach to the use of technology. It is submitted that approaches based on intersectional and gender theories provide the most complete methodological approach, one cognizant of the lived realities of survivors and sensitive to the potentials for harm. Such approaches will help minimize invisibilities and bias and provide investigators with the most comprehensive and relevant contextual information necessary to investigate these crimes ethically, responsibly, and competently. This thesis examines the historical and contemporaneous invisibilization of SGBV atrocity crimes and outlines arguments for, and approaches to, the use of intersectional theoretical methodologies and analyses in the use of digital open sources for the investigation of SGBV atrocity crimes.
ASPETAR – Women’s Football (Summaries)
Authors:   Revista de Medicina Desportiva informa, Ribeiro Basil
Published: February 2024

Summaries of: 1. “Female athlete health in women’s football” 2. “ACL rehabilitation in elite female footballers” 3. “Groin Pain in women’s football” 4. “Embracing women’s football growth at your club”.
PENGARUH SUPLEMENTASI MINERAL MIKRO ORGANIK TERHADAP JUMLAH ERITROSIT, HEMOGLOBIN, DAN HEMATOKRIT KAMBING PERAH JAWARANDU
Authors: Ekasari Yustia , Muhtarudin Muhtarudin , Siswanto Siswanto , Suharyati Sri
Published: February 2024

Tujuan penelitian ini adalah untuk mengetahui jumlah eritrosit, kadar hemoglobin, dan nilai hematokrit kambing perah Jawarandu yang diberi suplementasi mineral mikro organik dalam ransum di Mulia Farm, Negrisakti, Kabupaten Pesawaran Lampung. Penelitian ini merupakan penelitian eksperimental dengan menggunakan Rancangan Acak Kelompok (RAK) yang terdiri dari 4 perlakuan yaitu R0: Ransum Basal, R1: Ransum Basal + (Zn-Lysinat 20 ppm, Cu-Lysinat 5 ppm), R2: Ransum Basal + (Zn-Lysinat 40 ppm, Cu-Lysinat 10 ppm), R3: Ransum Basal + (Zn-Lysinat 60 ppm, Cu-Lysinat 15 ppm) setiap kelompok berisi 4 ekor kambing perah Jawarandu dengan 3 ulangan. Pemeriksaan sampel darah dilakukan di Laboratorium, Balai Besar Laboratorium Kesehatan, Palembang (BBLK Palembang) mengguakan metode B. Cell Counter dan Manual. Data yang diperoleh ditabulasikan dan kemudian dianalisis dengan analisis ragam (ANOVA) dengan taraf 5%. Hasil analisis menunjukkan bahwa suplementasi mineral mikro organik dalam pakan tidak memberikan pengaruh yang nyata (P>0,05) terhadap jumlah eritrosit, hemoglobin dan hematokrit kambing perah Jawarandu. Dari hasil analisis statistik sampel darah kambing perah Jawarandu didapatkan rata-rata jumlah eritrosit pada perlakuan (R0) 2,41±0,52 x 106/μL; (R1) 1,63±0,19 x 106/μL; (R2) 2,19±0,31 x 106/μL ; (R3) 1,92±0,28 x 106/μL. Rata-rata kadar hemoglobin pada perlakuan (R0) 9,37±0,05 g/dL ; (R1) 8,23±0,58 g/dL ; (R2) 8,5±0,87 g/dL ; (R3) 7,63±2,11 g/dL. kemudian rata-rata nilai hematokrit (±SD) pada perlakuan (R0) 9,00±2% Vol; (R1) 5,67±0,58% Vol; (R2) 8,33±0,58% Vol; (R3) 6,67±1,15 % Vol.  Dari hasil penelitian disimpulkan bahwa jumlah eritrosit, hemoglobin dan hematokrit pada kambing perah Jawarandu yang diberi suplementasi mineral mikro organik dalam ransum masih berada pada kisaran normal meskipun mendekati batas minimal.
EFEKTIVITAS SUPLEMENTASI JINTAN HITAM (Nigella sativa) TERHADAP TITER ANTIBODI AVIAN INFLUENZA (AI) DAN NEWCASTLE DISEASE (ND) PADA AYAM ULU BETINA
Authors: Habiahan Renta Enjelina , Siswanto Siswanto , Santosa Purnama Edy , Hartono Madi
Published: February 2024

Penelitian ini bertujuan untuk mengetahui efektivitas suplementasi Jintan Hitam (Nigella sativa) yang ditambahkan dalam pakan komersil terhadap titer antibodi Avian Influenza (AI) dan Newcastle Disease (ND) pada ayam Unggas Lestari Unggul (ULU) betina.  Penelitian ini dilaksanakan pada Desember 2022 hingga Februari 2023 di Kandang Laboratorium Lapang Terpadu Fakultas Pertanian, Universitas Lampung dan Laboratorium Medilab PT. Medion Lampung.  Bahan yang digunakan terdiri dari Day Old Chick (DOC) ayam ULU betina, ekstrak Jintan Hitam, vaksin dan lainnya.  Penelitian ini dilaksanakan secara eksperimental terdiri dari 4 perlakuan dan 3 ulangan yaitu P0 sebagai kontrol, P1 diberi ekstrak Jintan Hitam sebanyak 36 mg/kg BB/hari; P2 sebanyak 72 mg/kg BB/hari; dan P3 sebanyak144 mg/kg BB/hari.  Data pengamatan yang telah diperoleh disajikan dalam bentuk tabulasi dan histogram kemudian dianalisis secara deskriptif.  Hasil penelitian ini menunjukkan nilai rata-rata titer antibodi Avian Influenza tertinggi yaitu pada P3 (log 255,22) dan titer antibodi Newcastle Disease tertinggi pada P3 (log 743,11).
Design e Mobilidade Urbana: a experiência do usuário em interfaces de aplicativos baseado em localização para transporte público
Authors: Pedro Morais Guedes Joao , Guilherme da Silva Santa Rosa José , Falcão Peixoto Gustavo André
Published: February 2024

Este trabalho teve como objetivo geral propor diretrizes para projetos de interfaces gráficas para sistemas de comunicação de mobilidade urbana perante a avaliação da Experiência do Usuário (UX) em interfaces de aplicativo de informações para transporte público na capital paraibana João Pessoa. Para isso, utilizou-se como objetos de estudo três plataformas mobile de transporte público de passageiros: o Moovit, o Jampabus e o CittaMobi. A fim de alcançar os resultados propostos, o delineamento metodológico da pesquisa foi sistematizado em três fases distintas: a (a) pesquisa exploratória (revisão da literatura); a (b) avaliação pragmática, que usou os métodos de questionário de perfil do participante e teste de usabilidade; e por fim, a (c) avaliação hedônica, que buscou entender os atributos percebidos pelo usuário perante aplicação do questionário de diferencial semântico. Ao todo colaboraram com o estudo um total de 23 participantes, entre usuários experientes e inexperientes com os aplicativos do gênero e de gerações etárias diferentes. De acordo com o questionário de perfil dos participantes, todos os respondentes consideram importante o uso de aplicativos de informação para o transporte público, e dentre suas maiores necessidades estão olhar horários das conduções, ver trajetos alternativos e buscar informações sobre linhas. Os resultados permitem inferir que, usuários da geração Y experientes tiveram melhor eficiência e eficácia em relação aos inexperientes da mesma geração e à geração X como um todo. Com relação à percepção de satisfação dos usuários, a síntese dos dados do diferencial semântico mostra que a maioria atribui sentimentos agradáveis com relação à estética, os aspectos emocionais e usabilidade da interface. Por fim, gerou-se diretrizes de projeto de desenvolvimento para interfaces de informação de transporte público e um protótipo de alta fidelidade como produto modelo levando em consideração algumas insatisfações observadas na pesquisa.
Making Open Resources Discoverable: Collaborative Approaches for Enhanced Access
Authors: Mi Jia
Published: January 2024

This article explores collaborative efforts to enhance the discoverability of open access resources. It highlights the pivotal role of librarians, educators, library system platform vendors, and publishers in improving access to these valuable resources. Through collective expertise and cooperation, these collaborative approaches aim to unlock the potential of open resources, benefiting researchers, students, and the broader academic community. By working together and leveraging their collective knowledge, these collaborative efforts promise to tap into the wealth of open resources, making them more accessible for professors, students, and the broader academic community.
Interpretasi Konsep Accelerationism; Kapitalisme yang Berjalan dalam Film Interstellar (2014) dan The Platform (2019)
Authors: Syahadah Amalia Utammi , Tambunan Shuri Mariasih Gietty , Suharjo Rias Antho Rahmi
Published: January 2024

Accelerationism plays a significant role in advancing scientific knowledge and the framework of human existence. Its contributions are manifested in facilitating convenient and swift access to information sources, digital communication, and the availability of diverse technological tools aiding various professions. On the contrary, accelerationism leads to a series of disparities between capitalism and modernism. It also results in humans losing control over themselves, time, and life and even contributes to destroying species and the environment. The situational analysis of accelerationism in this study aligned with Liu's findings in "On the Accelerationist Critique of the Problem of Capitalist Modernity" (2022), highlighting the inseparable dual nature of accelerationism concerning capitalism and modernism. The fluid and straightforward concept of accelerationism can be observed in popular cultural products such as movies. Movies like Interstellar (2014) and The Platform (2019) encapsulate the concept of accelerationism within the scope of capitalism from varying perspectives.This content-analysis study aimed to distinguish the interpretations of accelerationism within Interstellar and The Platform as portrayed through scenes, dialogues, and other cinematic elements. The findings of the study, which employed a qualitative descriptive approach, were the interpretation of accelerationism within certain scenes of Interstellar depicting Earth's demise and the agenda of rescuing humanity by journeying to another planet. Accelerationism was also interpreted through dialogues and metaphorical scenes illustrating the concept of the capitalist food-chain mechanism in the prison cells of The Platform.
Epidémia bez konca. Čierny kašeľ vo farnosti Detva v 60. rokoch 19. storočia
Authors: Golian Ján
Published: February 2024

The article deals with the occurence of whooping cough epidemics using the example of the parish of Detva in the 1860s. However, the problem is more complicated in that the disease appears in the church registers as a cough (tussis), not as a whooping cough (pertussis / tussis convulsiva). Therefore, it was repeatedly verified in the medical literature and sources of the time whenever these terms are correlated. I present how whooping cough is characterized, and how its epidemics manifested themselves in the past. Another part of the text is an analysis of register records, indicating cough, or whooping cough as the cause of death based on records of burials from the parish of Detva in today’s central Slovakia. Victims who perished of a „cough“ died in every year of the analyzed decade. That was also the main reason why I chose this period. My goal was to find out the basic demographic characteristics of the epidemics, such as the average age of the victims, the gender ratio and the proportion of deaths of cough victims to other deceased. Then I would calculate the crude death rate of whooping cough victims and analyzing the seasonality of epidemics. In addition, the research also follow the course of the infection in different parts of the parish, comparing the primary centre of the parish, i.e., the town of Detva, with the periphery of the region, which was made up of estates scattered in the hills.