bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative evaluation of autologous platelet rich plasma and triamcinolone acetonide injection in the management of erosive lichen planus and oral submucous fibrosis: a clinical study
Authors: Sharma Shubham , Kamarthi Nagaraju , Sumit Goel  , Sangeeta Malik  , Swati Gupta  , Abhinav Sharma
Published: April 2023

Background: It is need of an hour to establish an effective and efficient treatment modality for OLP and OSMF with lesser or no adverse effects. Platelet rich plasma can be used in mucosal lesions as it has a high concentration of various growth factors and anti-inflammatory properties. It could be a better novel substitute to the corticosteroid without any side effects. The present study is an effort to evaluate the therapeutic effects of intralesional injection of PRP in oral erosive lichen planus and OSMF compared to intralesional corticosteroids in the same patient.
Methods: It was a randomized controlled clinical study consisting of 40 patients between the age groups of 18-60 years visiting dental OPD diagnosed clinically with either erosive lichen planus or OSMF. Triamcinolone 40 mg(1mg/ml) mixed with 2% (1:80,000) lignocaine hydrochloride was injected into the lesion on one side in case of erosive lichen planus and into the submucosal plane and fibrous bands in case of OSMF patients. Autologous PRP was prepared and injected on the other side in same patients. At every visit, all the patients were evaluated for pain and burning sensations, size, and severity of the lesion, and interincisal mouth opening (mm). The parameters were measured and recorded during the patient’s every visit. All the results were obtained and statically analyzed.
Results: Intralesional injections of triamcinolone acetonide and PRP are effective in reducing pain and burning sensation in OSMF, but PRP is less effective in improving cheek flexibility as compared to triamcinolone acetonide. In OLP, both triamcinolone acetonide and PRP are almost equally effective in reducing the size of the lesion. However, PRP shows slightly better results in reducing the severity of the lesion and in pain and burning sensation in the patients of OLP as compared to intralesional triamcinolone acetonide.
Conclusions: Thus, PRP is an effective modality in treating both OSMF and oral erosive lichen planus with no adverse effects.
Clinico-epidemiological study of leprosy in a tertiary care hospital of Eastern India
Authors: Agrawal Nisha , Saha Tirtha Raj , Barua Jayanta Kumar , Banerjee Gautam , Chatterjee Kingshuk , Halder Saswati , Samanta Prabal
Published: April 2023

Background: Accurate diagnosis of leprosy is of paramount importance, because delays and misdiagnosis are more common in non-endemic zones. It has a long incubation period, varied clinical presentations, and reaction states which can present in any point of lifetime, becoming more challenging for proper management of this enigmatous disease.
Methods: This was conducted as an institution based cross- sectional study over a period of 12 months. 100 patients were selected. Inclusion and exclusion criteria were maintained. Data collected was checked, tabulated, statistically analysed and compared with existing literature.
Results: In our study, majority, 49% belonged in age group of 41-60 yrs, only 6% were less than 20 years old. Male: female ratio was 3.34. 62% were from rural areas. Family history of Hansen was present in 5%. 6% had Histoid while 5% had pure neuritic representing least common subtypes. Most common occupations were Housewives (19%), shopkeepers (16%) and office workers (16%). 59% presented with hypoesthesia, 28% with fever. 59% belonged to borderline, 27% belonged to polar spectrum. Trophic ulcers were found in 20%, clawing of digits in 27%.
Conclusions: Leprosy is still a pressing problem in our country. A considerable number of children and adolescents get affected indicating high rate of transmission in community. A comprehensive approach includes proper diagnosis, treatment, and identification of reaction patterns, prevention of disability and deformities, and implementation of rehabilitation measures.
An institution-based non-randomised prospective study to estimate the efficacy and adverse effect profile of apremilast for moderate to severe refractory palmoplantar psoriasis
Authors: Agrawal Nisha , Joanna Rongong Sabina Liangom , Halder Saswati , Barua Jayanta Kumar , Satsangi Param , Halder Asim Kumar , Samanta Prabal
Published: April 2023

Background: Psoriasis is an immune-mediated inflammatory papulo-squamous disorder presenting as chronic plaque, pustular, erythrodermic, nail, scalp, drug induced, inverse, guttate etc. Palmoplantar psoriasis causes significant functional, cosmetic and psychological disability. Apremilast is a relatively newer drug being PDE-4 inhibitor, having negligible adverse effects with minimum blood monitoring.
Methods: It is an institution-based, non-randomised, prospective study conducted over a period of 3 months. 42 patients of moderate to severe disease (assessed using PPPASI), refractory to conventional line of therapy (for atleast 3 months) or had contraindications for the same were selected from our Dermatology OPD. Follow up was done monthly for 6 months.
Results: 42% of the patients were good responders. 1 patient did not respond and 2 had progression of the disease. There was a decrease in the mean DLQI from a baseline of 25 to less than 15 by the end of 1st month and around 5 by the end of 6th month.60% of patients showed onset of response by the 1st month. 45% of the patients showed adverse effects, mostly being nausea followed by dizziness.
Conclusions: From our study and those in the existing literature, it can be inferred that apremilast is a promising drug for palmoplantar as well as other forms of psoriasis, especially in patients with comorbidities or treatment refractory psoriasis.
Mobility Restrictions and Automation in the Developing World: Evidence from Peru's Labor Market
Authors: Benitez-Rueda Miguel , Domínguez Nicolás , Parrado Eric
Published: April 2023

Mobility restrictions have the potential to accelerate automation. Using difference-indifferences and triple-differences empirical strategies, and leveraging cross-industry variation in mobility restrictions and within-industry variations in automation risk, this paper estimates the impact of pandemic-related restrictions on automation in Peru. Our results indicate that mobility restrictions significantly decreased employment rates (22.5%) and hourly wages (74.1%) for workers in highly automatable jobs up to 18 months after the shock. These effects were particularly pronounced among women, small and medium-sized firms, informal workers, and individuals with low and medium skill levels working in manufacturing, construction, and services. Evidence suggests that occupational mobility from high-risk to low-risk jobs drove recovery afterwards.
Identification and functional analyses of a novel FOXL2 pathogenic variant causing blepharophimosis, ptosis, and epicanthus inversus syndrome
Authors:   Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100041, China, Yan Yu-Cheng , Fan Jin-Cai ,   Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100041, China
Published: April 2023

AIM: To discover the molecular pathogenic basis of the blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES), and to predict the clinical subtype according to in vitro experiments, which is significant to the prognosis.
METHODS: A 3-year-old sporadic female patient with typical clinical manifestations of BPES was enrolled. The coding region of forkhead box L2 (FOXL2) gene was sequenced, and the functional assays were performed in vitro by Western blotting, subcellular localization experiment, luciferase reporter assay, and quantitative real-time polymerase chain reaction.
RESULTS: A novel FOXL2 point pathogenic variant (c.274G>T) was detected, resulting in a truncated protein (p.E92*). Functional studies demonstrated that the FOXL2 pathogenic variant induced the subcellular mislocalization and the abnormal transcriptional activity on promoters of the steroidogenic acute regulatory protein (StAR or STARD1) gene and the odd-skipped related 2 transcription factor (OSR2) gene.
CONCLUSION: A novel pathogenic variant is identified to expand the spectrum of the known FOXL2 mutations. The in vitro experiments provide reference data and more insights to the molecular pathogenesis of BPES. The predicted high risk of ovarian insufficiency makes it significant for the patient enrolled to have further follow-up and therapy concerning female endocrinology.
Visual function and biofeedback training of patients with central vision loss: a review
Authors:   Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100040, China, Deng Yu , Wang Jian-Wei ,   Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100040, China, Li Yuan-Yuan ,   Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100040, China, Liu Zi-Qiang ,   Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100040, China
Published: April 2023

Older individuals with macular diseases, such as age-related macular degeneration, experience central vision loss (CVL) due to degeneration of their photoreceptors and retinal cells. Patients with CVL may experience various vision impairments, including of visual acuity, fixation stability, contrast sensitivity, and stereoacuity. After CVL, most patients develop a preferred retinal locus outside the affected macular region, which serves as a new visual reference. In this review, we provide an overview of the visual function and impairment in individuals with CVL. In addition, the important role of biofeedback training on the visual function and activity of individuals with CVL is also reviewed. Accordingly, the location and development of the preferred retinal loci are discussed. Finally, this review discusses how to conduct biofeedback training to treat individuals with CVL.
C Language Extension to Support Procedural-Parametric Polymorphism
Authors: Legalov Alexander I. , Kosov Pavel V.
Published: April 2023

Software development is often about expanding functionality. To improve reliability in this case, it is necessary to minimize the change in previously written code. For instrumental support of the evolutionary development of programs, a procedural-parametric programming paradigm was proposed, which made it possible to increase the capabilities of the procedural approach. This allows to extend both data and functions painlessly. The paper considers the inclusion of procedural-parametric programming in the C language. Additional syntactic constructions are proposed to support the proposed approach. These constructions include: parametric generalizations, specializations of generalizations, generalizing functions, specialization handlers. Their semantics, possibilities and features of technical implementation are described. To check the possibilities of using this approach, models of procedural-parametric constructions in the C programming language were built. The example in the article demonstrates the flexible extension of the program and support of multiple polymorphism.
The Optimized Algorithm of Finding the Shortest Path in a Multiple Graph
Authors: Smirnov Alexander Valeryevich
Published: April 2023

In this paper, we study undirected multiple graphs of any natural multiplicity $k>1$. There are edges of three types: ordinary edges, multiple edges and multi-edges. Each edge of the last two types is a union of $k$ linked edges, which connect 2 or $(k+1)$ vertices, correspondingly. The linked edges should be used simultaneously. If a vertex is incident to a multiple edge, it can be also incident to other multiple edges and it can be the common end of $k$ linked edges of some multi-edge. If a vertex is the common end of some multi-edge, it cannot be the common end of another multi-edge.

As for an ordinary graph, we can define the integer function of the length of an edge for a multiple graph and set the problem of the shortest path joining two vertices. Any multiple path is a union of $k$ ordinary paths, which are adjusted on the linked edges of all multiple and multi-edges.
In the article, we optimize the algorithm of finding the shortest path in an arbitrary multiple graph, which was obtained earlier. We show that the optimized algorithm is polynomial. Thus, the problem of the shortest path is polynomial for any multiple graph.
Проблемы осуществления корпоративного управления
Authors: Колиева А.Э. , Сачян А.К.
Published: April 2023

В данной статье рассмотрено понятие и основные характеристики корпоративного управления; даны сущностные описания современных тенденций и требований, позволяющих достичь экономических целей деятельности компании XXI века; проведен анализ некоторых наиболее сложных проблем корпоративного управления и предложены перспективные пути их устранения.
Правовой статус женщины в современном Египте
Authors: Исхакова Е.Р.
Published: April 2023

В данной научной статье рассмотрены особенности политико-правового положения женщин в Египте. Исследовано отношение арабского мира к принципам и нормам, принятым международным сообществом относительно прав женщин. Представлены принципы построения положения женщины в египетском государстве. Стоит отметить, что в современном мире, относительно прав женщин, происходит сближение законодательства Египта, как одного из представителей арабского мира, с европейскими стандартами. На основании проведенного анализа сделан вывод и сформулированы предложения по улучшению политико-правового положения женщин в Египте.
Impact of COVID-19 on clinical trials protocol amendments
Authors: Eleskina Anastasia , Filippova Olga V. , Pyatigorskaya Nathalia V.
Published: April 2023

Introduction: The COVID-19 pandemic situation had a great impact on all spheres of people’s lives. It also affected clinical trials as Sponsors, sites and investigators faced a number of problems, such as systematic IMP taking, adherence to protocol visits, efficacy evaluations, laboratory procedures, and analyses.
Materials and Methods: The amendments issued in 2020 were compared with the amendments issued in the previous three years 2017-2019. The literature about COVID-19 and its impact on clinical trials were analyzed. Clinical trial protocol amendments published in 2020 were studied to evaluate pandemic influence on ongoing clinical studies. Statistical processing of the results was carried out using the correlation analysis.
Results:  The highest quantity of amendments was released in 2020 –14 (36%). Fewer amendments came out in 2019 – 13 (33%), in 2018 – 9 (23%), and the fewest amendments were issued in 2017 – 3 (8%).
 Conclusion: The existing system of clinical trial protocol creation is dependable and adequate. It allows reacting flexibly to unexpected challenges, like COVID-19, fully complying with the prescribed procedures and carefully observing participants’ safety and well-being. That is why the current pandemic did not affect the number of protocol amendments.
Graphical Abstract
Delivery features of pregnant women with a uterine scar
Authors: Nikolaeva E. I. , Sulima A. N.
Published: April 2023

Vaginal delivery after a Caesarean section remains a controversial topic: there is a lack of reliable data to help doctors and women in labour to determine the best option for delivery during subsequent pregnancy. The review analyzed and summarized the results of the studies devoted to childbirth of pregnant women with scars on the uterus, considered the advantages and disadvantages of vaginal childbirth and repeat Caesarean section, the frequency of complications in the attempt of vaginal childbirth in women with scars on the uterus has been assessed. The modern medical literature available in open sources has been studied: Russian-language scientifc electronic libraries eLibrary and CyberLeninka, Englishlanguage database of medical and biological publications PubMed. It is necessary to consider the data of anamnesis and clinical-instrumental data when choosing the best management tactics of pregnancy and delivery for women with scars on the uterus. Attempting to deliver vaginally helps to reduce maternal and neonatal morbidity, and a large number of studies on this issue should help to reduce the number of unwarranted repeat Caesarean sections. Vaginal delivery after a Caesarean section is an opportunity to avoid severe abdominal surgery and negative consequences associated with repeated Caesarean sections.
Features of matrix metalloproteinases MMP2, MMP3, MMP9 genes regulatory region polymorphism in patients with uterine fbroids
Authors: Shevchenko A. V. , Prokofev V. F. , Konenkov V. I. , Timofeeva Yu. S. , Koroleva E. G. , Marinkin I. O. , Aidagulova S. V.
Published: April 2023

Violation of the extracellular matrix components synthesis regulation contributes to the formation and growth of uterine fbroids (MM). Changes of collagen metabolism in connective tissue may be associated with polymorphism of matrix metalloproteinase (MMP) genes. Aim of the study was to analyze of the association of regulatory regions of matrix metalloproteinase genes MMP2 (rs243865), MMP3 (rs3025058), MMP9 (rs3918242) with the development of uterine myoma, its histological form, several concomitant gynecological diseases. Material and methods. The clinical study of 69 patients (23–54 years old) with uterine myoma was conducted. According to the anamnesis, 57.9 % of patients had childbirth, 46.4 % of women had an artifcial termination of pregnancy, and 15.9 % of women had endometriosis. In histological examination, in 48.14 % the nodes corresponded to the phenotype of simple fbroids with a large proportion of fbrous tissue, 51.6 % with the phenotype of proliferating fbroids. The comparison group is represented by a random population sample of women from Western Siberia. 183 women without pronounced gynecological pathologies were examined. MMP2-1306 C/T polymorphism was analyzed by TaqMan, MMP3-1171 5A/6A, MMP9-1562 C/T by restriction fragment length polymorphism method. Results. The genotype frequencies of the analyzed genes did not signifcantly diﬀer between the groups. The complex genotype MMP2-1306CC:MMP3-11715A6A:MMP9-1562CT was decreased in women with uterine myoma relative to the persons of the comparison group. In endometriosis patients MMP9-1562CC genotype was reduced and heterozygosity was increased relative to patients without endometriosis. The frequency of MMP2-1306CC:MMP9-1562CT complex genotype is signifcantly higher in women who gave birth than in women who did not give birth. Complex genotypes diﬀerences between histological variants of uterine myoma were revealed. Conclusions. The results of the study show the signifcance of polymorphism eﬀect of the regulatory regions of the MMP genes in the development and nature of the course of uterine myoma.
El territorio en la formación del Estado peruano (1821-1830)
Authors: Gálvez M. José Francisco (Gálvez Montero)
Published: April 2023

A lo largo de la historia, la formación del Estado peruano ha sido gravítante. Su problemática fue seguida a través de las relaciones de poder y de la presencia del pueblo, el que ha buscado una participación mayor en las gestiones del Estado durante décadas. Conjuntamente con dicha participación encontramos un tercer elemento del Estado, que es el territorio. Las siguientes líneas pretenden proporcionar algunos elementos ref erídos a este tema en la constitución de la organización jurídico política durante los primeros años de vida republicana. Para esto, las disposiciones de la administración nacional hasta 1827, son fundamentalmente nuestro marco referencial.
La Autonomía Universitaria : un ejemplo de espacio político-jurídico
Authors: Ortiz Caballero René
Published: April 2023

Más allá de la consabida estructura dé normas e instituciones con poder coercitivo, al Derecho difícilmente se le atribuye otra apariencia. A veces, se le suele adscribir elementos de naturaleza política, económica o, genéricamente, cultural; sin embargo, es difícil imaginar o concebir un "espacio jurídico" sí no es con relación a esas normas e instituciones y a las cosas materiales que les sirven de objetos. Así, por ejemplo, un predio, ubicable por sus linderos, es la circunstancia material de la que se permite predicar el derecho de propiedad, regulado en el Código Civil; también el territorio , delimitado por sus fronteras, es el objeto tangible sobre el cual ejerce soberanía el Estado, de acuerdo con el art. 54º de la Constitución Política del Perú. En ambos casos, existe un espacio, un lugar, sobre el que ciertos sujetos -el ciudadano o el Estado- realizan legítimamente determinadas acciones posesorias; por ejemplo, construir una casa o una carretera, respectivamente, de modo que podamos afirmar: ¡ejercen su derecho!
La Universidad de San Marcos en la historia del Derecho Indiano
Authors: Ugarte del Pino Juan Vicente
Published: April 2023

Juan Vicente Ugarte del Pino, En cumplimiento de un viejo y tradicional rito universitario, traigo el señalado encargo de pronunciar las palabras de «Recibimiento» en nuestro claustro a los miembros del Instituto Internacional de Historia del Derecho Indiano, que celebran en Lima su décimo cuarto Congreso.
Los autos acordados de la Real Audiencia Territorial de Puerto Rico
Authors: Guiven Flores César
Published: April 2023

En el segundo viaje que realizara el ilustre almirante Cristóbal Colón, reconoció y tomó posesión de las tierras de Borinquén ó Borinquen, el 19 de noviembre de 1493, bautizándola bajo el nombre de San Juan Bautista. Recién en 1508 el aguerrido conquistador Juan Ponce de León, quien se había distinguido en la pacificación de los indios de La Española, solicitó permiso al gobernador Fray Nicolás de Ovando para explorarla, firmando una capitulación el 15 de junio de 1508, y al año siguiente firma otra capitulación que es complemento de la primera que se desconoce su texto.
Algo más sobre los pleitos colombinos : Nuevos elementos jurídicos
Authors: Vila Vilar Enriqueta
Published: April 2023

Las Capitulaciones de Santa Fe que los Reyes Católicos firmaron con Cristóbal Colón y los inmediatos y posteriores privilegios que le fueron otorgados antes del descubrimiento de América, proporcionaron al genovés una serie de concesiones y mercedes para él y sus herederos que, ante la realidad mostrada por los viajes colombinos y los coetáneos viajes andaluces, se hizo patente la imposibilidad de mantener tales concesiones y pronto la corona intentó limitarlas.
Aplicación de técnicas pedagógicas modernas a la enseñanza del Derecho Indiano y las demás materias histórico-jurídicas
Authors: Rabinovich-Berkman Ricardo David
Published: April 2023

El objeto de esta breve comunicación es compartir con los colegas profesores de Historia del Derecho algunas experiencias que, en compañía de otros docentes, venimos realizando, desde hace varios lustros, en la enseñanza de las materias histórico-jurídicas.
La oposición del Consulado de Cargadores a Indias a la creación de compañías comerciales privilegiadas (S. XVII)
Authors: García Fuentes Lutgardo
Published: April 2023

En el siglo XVI aparecieron, como es sobradamente sabido, nuevas formas de organización comercial: las compañías reguladas, con protección del Estado, como los Merchant Adventures de Inglaterra; las Joint Stock Companies, que nacieron dotadas de un cierto espíritu capitalista muy diferenciador, que se denomina mercantilista, con el capital dividido en acciones y liquidación de beneficios mediante el sistema de prorrata; y las compañías de navegación.
El régimen de estanco del tabaco bajo la administración de don Francisco de Saavedra (1783-1788)
Authors: Morazzani de Pérez Enciso Gisela
Published: April 2023

La llegada de don Francisco de Saavedra a la Intendencia de Ejército y Real Hacienda de la Capitanía General de Venezuela en sustitución del Intendente General, don Josef de Abalos, no alteró la continuidad del programa de gobierno ya iniciado por su antecesor de regentar el estanco de la renta de tabaco directamente o a través de su arriendo. La labor desplegada por el nuevo funcionario se desarrolló dentro de un orden dirigido a continuar el plan oficial de centralización y a introducir los cambios administrativos que exigía el proceso evolutivo del régimen de estanco para favorecer y consolidar el tributo.
La tenencia de la tierra. El contrato de arrendamiento rural en el Río de la Plata (siglo XVIII)
Authors: Storni Carlos Mario
Published: April 2023

El presente trabajo forma parte de una investigación mayor que con algunos colegas estamos realizando en el Instituto de Investigaciones de Historia del Derecho de Buenos Aires, sobre el derecho indiano municipal o local y la pervivencia del derecho indiano luego de la emancipación americana, investigación que se realiza con el apoyo del Centro de Estudios Hispánicos e Iberoamericanos de la Fundación Carolina.
El gobierno del Consejo de Indias entre los siglos XVI y XVII
Authors: Escudero José Antonio
Published: April 2023

Es bien sabido que el gobierno de Ultramar, o más propiamente, el gobierno central de Ultramar bajo los Austrias, correspondió en España a un poderoso organismo de sonoro nombre: el Consejo Real y Supremo de las Indias. Ahora bien, al igual que las Indias daban cabida a una multitud de gentes, territorios y problemas heterogéneos y distintos, aquel majestuoso Consejo de Indias, aparentemente monolítico e impasible, dio cabida a un mundo interior rico, problemático y cambiante.
La Secretaría de la Presidencia del Consejo de Indias y sus competencias documentales
Authors: Gómez Gómez Margarita
Published: April 2023

El presente estudio tiene por objeto analizar las funciones de la llamada Secretaría de la Presidencia del Consejo de Indias, una institución muy poco conocida cuyo trabajo consistía en auxiliar al presidente o gobernador del Consejo en el desempeño de sus funciones.
Las islas americanas
Authors: Tamm Ditlev
Published: April 2023

El tema que propone la ponencia que les voy a presentar hoy es, en cierto modo, una continuación de mi intervención en nuestro congreso de hace tres años en San Juan de Puerto Rico. Estuvimos entonces en el Caribe, geográficamente muy cerca de las tres islas vírgenes que constituían la colonia danesa en las Indias, las islas de Santo Tomás, San Juan y Santa Cruz, conocidas en la lengua oficial danesa del siglo XVIII como las Islas Americanas. La más grande de esas islas, Santa Cruz (St. Croix), fue adquirida en 1733. Santo Tomás ya había sido ocupada en los años 1670. En 1755 las islas pasaron de la Compañía de las Indias al gobierno danés.
El control de la prensa en América a fines del siglo XVIII : El caso de la Gaceta de Guatemala
Authors: Torres Aguilar Manuel
Published: April 2023

Desde 1763 el Consejo de Castilla se encargó de la censura de los periódicos, labor que con anterioridad había venido desempeñado un juez de imprentas. Sobre el particular, desde bien pronto se distinguió entre el proyecto de elaboración de un periódico y la práctica diaria de la publicación del mismo.
Inovação legislativa e unificação jurisprudencial como instrumento de racionalização no Brasil pombalino e pós-pombalino, 1750-1808 (O caso da justiça e do Direito)
Authors: Wehling Arno
Published: April 2023

La historiografía es muy consciente de la tendencia hacia la centralización política y la centralización administrativa, observable en la mayoría de los estados europeos en el siglo XVIII, particularmente desde mediados del siglo XVIII en adelante. Identificadas por algunos autores del siglo XIX como un ejercicio de «despotismo ilustrado», estas acciones apuntaban, en su forma extrema, a «arrasar todo ante el rey», en expresión de un historiador portugués. En el caso de la administración colonial de Brasil, desde el consulado pombalino, iniciado en 1750, hasta la instalación del gobierno metropolitano en Río de Janeiro, en 1808, se puede reconocer esta tendencia.
La Bula de Cruzada en Perú
Authors: Benito Rodríguez José Antonio
Published: April 2023

El presente ensayo quiere acercarnos a una de las realidades institucionales indianas más universales en el tiempo, en el espacio y en las personas, La Bula de Cruzada en Indias, de acuerdo con la tesis doctoral elaborada en Valladolid, en 1996, con la documentación encontrada en el Archivo General de Simancas, y a la que se añaden ahora detalles particulares del virreinato peruano, que nos servirán para entender algunos pormenores de los primeros años de su establecimiento.
Los aranceles de los derechos eclesiásticos en el obispado del Tucumán
Authors: Miller Astrada Luisa
Published: April 2023

La nueva política implementada por Felipe II respecto a sus dominios de Indias estuvo orientada hacia la pacificación que habría de lograrse mediante el poblamiento y la evangelización. De allí en más, fue continuada por los monarcas que concedieron en la legislación real, un importante espacio consagrado a todo lo atinente a la evangelización y el modo de llevarla a cabo.
Personas : de los hijos y potestad de los padres
Authors: Díaz-Melián de Hanisch Mafalda Victoria
Published: April 2023

La importancia de un manuscrito anónimo de 1830 titulado Recopilación de varios principios de derecho civil, de gentes y político, que refleja las lecciones del profesor Pedro Somellera, ha motivado el estudio del capítulo IV de la Recopilación que tiene por título «De los hijos, y potestad de los padres». Al introducir el tema de los hijos, la Recopilación cierra el manuscrito con la expresión «Basta de personas» y no se cree posible al tratar el derecho legislado dejar de tratar antes el tema Personas pues su explicación es necesaria e inexcusable.
Portugueses no Perú no seculo XVI
Authors: Mendonça Manuela
Published: April 2023

La aventura que, desde el primer cuarto del siglo XV, llevó a los portugueses a buscar nuevos lugares, desafiando el océano desconocido, pronto fue acompañada por el proceso de poblamiento de los mismos. Tal es el caso del archipiélago de Madeira que, descubierto oficialmente por João Gonçalves Zarco hacia 1420, vio el inicio de su poblamiento cinco años después. Lo mismo puede decirse de Santo Tomé y Príncipe que, descubierto a principios de la década de 1470, ya estaba siendo colonizado en la década siguiente. Idéntica situación ocurrió con el resto de tierras descubiertas, a saber, Brasil, cuya ocupación está documentada desde el primer contrato de arrendamiento, hecho por D. Manuel, en 1502.
Más allá de la obligación contractual en Juan de Solórzano y Pereyra
Authors: Bellomo Manlio
Published: April 2023

En la aventura ultramarina de los conquistadores españoles en principio fue la fuerza, del cuerpo y del hombre, la que afrontó las insidias del mar tempestuoso y las inmensas extensiones de las tierras desconocidas; fue la fuerza que se convirtió también en violencia sobre el territorio, sobre las casas, sobre los indios, y produjo rapiñas, saqueos, sangre y dolor. Pasado el primer ímpetu se encaminó, como era natural y obvio, a la experimentación de agregaciones sociales y políticas, y entre tantas se formó una, en el mundo agrario, denominada encomienda.
Decretos inhibitorios, justicia privativa provincial y local. El caso del Conde de Santa Rosa en Zacatecas (S. XVIII)
Authors: Enciso Contreras José
Published: April 2023

El ambiente urbano descrito por las autoridades locales coetáneas revela que la naturaleza y características propias de la población de Zacatecas a principios del siglo XVIII no difería mucho del que presentaba en sus tiempos fundacionales del siglo XVI. Por su valor descriptivo es pertinente transcribirlo.
El doctor Barón del Pozo, un pícaro letrado en el Virreinato Rioplatense
Authors: Leiva Alberto David
Published: April 2023

Juan José Mariano Barón del Pozo era sobrino de Felipe Santiago del Pozo, que fue Alcalde del Cabildo de Buenos Aires en el último tercio del siglo XVIII y que dejó al morir la suma de 9000 pesos, para fundar una capellanía a favor del primero de la familia que se ordenara sacerdote. Deseando ver cumplida una manda tan plausible, otra tía suya, Teresa de Pozo, casada con Simón González, se ofreció a costear los estudios de aquel pariente que se creyera con vocación para abrazar el sacerdocio.
Los Obispos-Virreyes en la Nueva España, una sola espada (1584-1696)
Authors: Ortiz Treviño Rigoberto Gerardo
Published: April 2023

No se ha alcanzado siquiera un siglo de la Historia del Derecho Indiano, y es sorprendente como ya se ha generado un patrimonio considerable de estudios sobre tan peculiar ordenamiento jurídico. En el entorno siempre imponente, de un congreso internacional como este, solo se puede afirmar que cualquier propuesta historiográfica resultaría una pincelada dentro de un gran mural. Más aún si se trata de hablar acerca de las muchas veces imperceptible frontera entre los gobiernos temporal y espiritual indianos.
La pervivencia de instituciones sucesorias castellano-indianas en las codificaciones hispanomericanas del siglo XIX
Authors: Guzmán Brito Alejandro
Published: April 2023

Que el derecho privado castellano-indiano vio prolongada su vigencia después de las sucesivas independencias de las diversas secciones de la América española, a partir de entonces constituidas en otros tantos Estado soberanos, y que, por ende, la independencia política no estuvo inmediatamente acompañada de una independencia jurídica, son hechos por todos conocidos, sobre los cuales no es necesario insistir aquí.
Pervivencia de normas y prácticas notariales indianas en el Derecho Patrio Chileno
Authors: Palacios Gómez Galvarino
Published: April 2023

La profesión de los escribas es necesariamente tan antigua como la invención de la escritura. Hace 5.000 años los sumerios y los egipcios tuvieron escuelas sacerdotales donde se educaban los futuros escribas. Las tuvieron también los hebreos, desde los tiempos de Edras, reconociendo a los escribas como doctores intérpretes de la ley, a quienes denominaron, precisamente, escribas de la ley; como magistrados llamados escribas del pueblo; y como escribas comunes, que prestaban servicios al público, parecidos a los que prestaron después escribanos y notarios.
El reflejo de la Partida III del Derecho Procesal español en los fallos de la Corte Suprema de la Nación Argentina
Authors: Zarazaga Luis Maximiliano
Published: April 2023

La influencia de la Partida III en el derecho procesal civil argentino ha sido fundamental tanto en el derecho precodificado como en el derecho codificado. Esto se refleja en los fallos de nuestro más alto tribunal, que es la Corte Suprema de la Nación, que desde su creación hasta a la actualidad la siguen citando.
Consolidación del constitucionalismo decimonónico y subsistencia del Derecho Indiano. El Congreso de la Confederación Argentina frente al orden jurídico anterior a la Independencia (1854-1861)
Authors: Abásolo Ezequiel
Published: April 2023

Superada por la actual historiografía indianista la idea de que la desaparición de las monarquías ibéricas derivó en el simultáneo e inmediato abandono, por parte de las nuevas naciones hispanoamericanas, de las normas, los métodos y las técnicas jurídicas aplicadas en las Indias durante el período hispánico, en la oportunidad me ocupo de estudiar la situación de algunos elementos indianos en una Argentina como la de mediados del siglo XIX, vale decir plenamente inmersa en el proceso de substitución de la antigua cultura jurídica, hasta entonces hegemónica.
Inicios del Derecho público en el ordenamiento jurídico peruano
Authors: Gálvez M. José Francisco
Published: April 2023

El Derecho junto al territorio, poder y pueblo formó parte de la nueva concepción de la organización jurídico-política desde el siglo XVIII. Fue en el período de transición, entre el final del dominio español y el inicio del Estado independiente, que sirvió como elemento de estabilidad y agente de cambio, promoviendo nuevas pautas en los lineamientos de la sociedad y en los roles de los individuos.
El indigenismo jurídico : de la caridad a la reivindicación
Authors: Ramos Núñez Carlos Augusto
Published: April 2023

Si el indígena fue un personaje ausente en los manuales y tratados, e incluso en los códigos decimonónicos, por el contrario, al iniciarse el Novecientos, los autores volcarán su atención hacia esa problemática en los diversos escenarios geográficos del país.
La regulación estatal del factor religioso en el siglo XIX en México : el ocaso del Patronato
Authors: Martínez de Codes Rosa María
Published: April 2023

La regulación del factor religioso en la América española del ochocientos requiere, en mi opinión, una precisión doctrinal respecto al sistema jurídico que lo rigió, a fin de clarificar continuidades y rupturas en el nuevo orden que las Repúblicas independientes se esforzaban en construir.
Pervivencia del Patronato Indiano en el período independiente. El caso del Colegio Mayor del Rosario de Bogotá (1810-1850)
Authors: Mayorga García Fernando
Published: April 2023

Dado que la naciente República de Colombia se proclamó heredera del derecho de Patronato ejercido durante el período hispánico por la Corona española, en el poder ejecutivo republicano recayó el Patronato sobre el Colegio Mayor que, durante los siglos coloniales, había estado en manos de los presidentes de la Audiencia primero y de los virreyes después, en su calidad de vicepatronos como representantes directos del Monarca.
The Effect of Capital Structure and Profitability on the Value of Pharmaceutical Companies Listed on the Indonesia Stock Exchange
Authors: Fauziah Fenty , Munawwaroh Tri , Rislawati Nita
Published: April 2023

Study this aim for analyze and explain influence capital structure and profitability to score company on company industry pharmacy on the Indonesia Stock Exchange. Population study this is company pharmacy listed on the Indonesia Stock Exchange period observation year 2019-2021. Methodology study this use purposive sampling method with total 8 companies. Analysis on research this conducted with use analysis multiple linear regression and assumption test classic on the SPSS program. by Partial results analysis panel data regression shows that influential capital structure positive significant to score company. Influence profitability by Partial show that results analysis influential panel data regression positive significant to score company. DER and ROA variables individually simultaneous show that take effect positive significant to score company. Enhancement price good stock take effect to decision investment. The more many investors invest, then will raise score company. Good profitability for company that is show ability company produce profit clean. High profitability will influence price stock later will attract investors to buy stock.
The Influence of Price Fairness, Promotion, and Perceived Ease of Use on the Repurchase Intention
Authors: Nur Amanda Putri Assyifa , Bernarto Innocentius
Published: April 2023

This research aims to analyze the positive influence of price fairness, promotion, and perceived ease of use on repurchase intention. The survey method was used to analyze the results. Data collection technique was carried out through a questionnaire instrument. Purposive sampling was applied in this study. The sample size was determined to be 400 samples. Questionnaires were distributed to the buyers who had made purchases at Lazada at least twice. Data analysis technique employed the Partial least Square-Structural Equation Modeling (PLS-SEM) approach of the SmartPLS program. The research results reveal that price fairness, promotion, and perceived ease of use have positive effects on the repurchase intention.
Hedonis Lifestyle on Impulse Buying Behavior Monzer Kahf Islamic Consumption Perspective
Authors: Sulistyowati Sulistyowati , Zainuna Alvy
Published: April 2023

Hedonic is a lifestyle of an individual to spend time having fun. This lifestyle triggers impulse buying behavior which is included in consumptive behavior. This study aims to answer the questions of how hedonic lifestyles affect impulse buying behavior and how hedonic lifestyles affect impulse buying behavior from the Islamic consumption perspective of Monzer Kahf. The type of research is field research which focuses on a case study. The research location is at PP Al-Fath Kediri. This research uses a qualitative approach. Data sources come from primary and secondary data collected through observation, interviews, and documentation. The validity of the data is carried out by increasing the accuracy of the research, using reference sources, triangulation, and conducting member checks. The results of this study indicate that (1) Students who live at PP Al-Fath prefer to spend their free time shopping online because they are considered more flexible. This is included in the hedonic lifestyle that can trigger impulse buying behavior. (2) The hedonic lifestyle of the impulse buying behavior of PP Al-Fath students contradicts the consumption theory expressed by Monzer Kahf, which includes rationalism and the concept of goods in Islam.
Penetrating right ventricular injury following a single gunshot to the left flank in Iraq: a case report
Authors: Majeed Zryan Salar , Othman Yad N. , Ali Razhan K.
Published: April 2023

A century ago, cardiac injuries usually resulted in death. However, despite all the advances in medicine, these injuries still have high mortality and morbidity rates. In the present case, we describe a patient with a bullet injury to the right ventricle who survived at our hospital despite the limitations of our center with regard to modalities and equipment. A 30-year-old man was brought to our emergency department with a bullet wound to his left flank. He was hemodynamically unstable. After only 8 minutes in the hospital and without further investigations he was rushed to the operating room. During laparotomy, a clot was visible in the left diaphragm, which dislodged and caused extensive bleeding. The decision was made to perform a sternotomy in the absence of a sternal saw. An oblique 8-cm injury to the right ventricle was discovered following rapid exploration. It was repaired without the need for cardiopulmonary bypass surgery. After a few days in the hospital, the patient was discharged home. In the event of a penetrating cardiac injury, rapid decision-making is crucial for survival. Whenever possible, the patient should be transferred to the operating room, as emergency department thoracotomies are associated with a high mortality rate.
Mortality and reoperation rate of biological versus mechanical Bentall-De Bono operation: a propensity-matched study
Authors: Perezgrovas-Olaria Roberto , Soletti Giovanni , Rahouma Mohamed , Dimagli Arnaldo , Harik Lamia , Cancelli Gianmarco , Yaghmour Mohammad , Polk Hillary , Closkey Brian , Wright Jessica , Gaudino Mario , Girardi Leonard N. , Lau hristopher
Published: April 2023

Objective: To assess follow-up mortality and reoperation rate in patients undergoing Bentall-De Bono operation according to the type of composite valve graft used. Methods: All consecutive adult patients operated on between May 1997 and December 2019 at our institution were included in the analysis and classified according to the use of a biological or a mechanical composite valve graft (bCVG or mCVG). The primary outcomes were follow-up mortality and reoperation rate. Secondary outcomes were operative mortality and major adverse events (MAEs) including operative mortality, myocardial infarction, cerebrovascular accident, dialysis, tracheostomy, and re-exploration for bleeding. Kaplan-Meier and competing risk analyses were used. Propensity matching analysis was used to balance differences in baseline characteristics between procedures. Results: Of 1,210 included patients, 798 received a bCVG and 412 a mCVG. The mean follow-up was 6.64 ± 0.21 years. The ten-year mortality rate was higher in the mCVG group (25.3% vs. 16.4%, P = 0.023). The ten-year reoperation rate was higher in the bCVG group (7.4% vs. 1.1%, P < 0.001). Overall operative mortality was 0.7%, and MAEs occurred in 6.2% of patients, with no significant differences between groups. Older age (hazard ratio [HR] 1.06, 95% confidence interval [CI: 1.04-1.08], P < 0.01), chronic obstructive pulmonary disease (HR 1.63, 95%CI: [1.01-2.64], P = 0.04), preoperative renal dysfunction (HR 3.08, 95%CI: [1.98-4.78], P < 0.001), New York Heart Association Class III/IV (HR 1.48, 95%CI: [1.04-2.10], P = 0.031), and mCVG (HR 2.15, 95%CI: [1.42-3.26], P < 0.001) were associated with higher risk of follow-up mortality. After propensity matching, the differences in mortality and reoperation remained significant. Conclusions: The Bentall-De Bono operation can be performed with consistently good results in experienced centers. Early outcomes are excellent regardless of the valve choice. In our study, the Bentall-De Bono operation with bCVG was associated with lower 10-year mortality but carried a higher risk of aortic reoperation. While the risk of reoperation is largely tied to valve choice, follow-up mortality is more likely to be influenced by patient comorbidities and risk factors.
Evaluation of DNA Methylation Profiles of LINE-1, Alu and Ribosomal DNA Repeats in Human Cell Lines Exposed to Radiofrequency Radiation
Authors: Ravaioli Francesco , Bacalini Maria Giulia , Giuliani Cristina , Pellegrini Camilla , D'Silva Chiara , De Fanti Sara , Pirazzini Chiara , Giorgi Gianfranco , Del Re Brunella
Published: April 2023

A large body of evidence indicates that environmental agents can induce alterations in DNA methylation (DNAm) profiles. Radiofrequency electromagnetic fields (RF-EMFs) are radiations emitted by everyday devices which have been classified as “possibly carcinogenic”, however their biological effects are unclear. As aberrant DNAm of genomic repetitive elements (RE) may promote genomic instability, here we sought to determine whether exposure to RF-EMFs could affect DNAm of different classes of RE, such as long interspersed nuclear element1s (LINE-1), Alu short interspersed nuclear element and ribosomal repeats. To this purpose, we analysed DNAm profiles of cervical cancer and neuroblastoma cell lines (HeLa, BE(2)C and SH-SY5Y) exposed to 900 MHz GSM-modulated RF-EMF through an Illumina-based targeted deep bisulfite sequencing approach. Our findings showed that radiofrequency exposure did not affect DNAm of Alu elements in any of the cell lines analysed. Conversely, it influenced DNAm of LINE1 and ribosomal repeats in terms of both average profiles and organization of methylated and un-methylated CpG sites, in different ways in each of the three cell lines studied.
Interrelationship between COVID-19 and coagulopathy: pathophysiological and clinical evidence
Authors: Ragnoli Beatrice , Da Re Beatrice , Galantino Alessandra , Kette Stefano , Salotti Andrea , Malerba Mario
Published: April 2023

Since the first description of COVID-19 infection, among clinical manifestations of the disease including fever, dispnea, cough, fatigue, it was observed a high incidence of thromboembolic events potentially evolving towars ARDS and COVID-associated-coagulopathy (CAC).The hypercoagulation state is based on an interaction between thrombosis and inflammation. The so-called CAC represents a key aspect in the genesis of organ damage from SARS-CoV-2. The prothrombotic status in COVID-19 disease can be explained by the increase of coagulation levels of D-dimer, lymphocytes, fibrinogen, IL-6 and prothrombin time. Several mechanisms have been hypothesized to explain this hypercoagulable process such as inflammatory cytokine storm, platelet activation, endothelial dysfunction and stasis for a long time. The purpose of this narrative review is to provide an overview of the current knowledge on the pathogenic mechanisms of coagulopathy that may characterize COVID-19 infection and inform on new areas of research. New vascular therapeutic strategies are also reviewed.