bluuebunny/crossref_metadata_2025 huggingface dataset:
3′UTRs Regulate Mouse Ntrk2 mRNA Distribution in Cortical Neurons
Authors: Chen Shangqin , Zhu Jinjin , Li Peijun , Xia Zhaonan , Tu Mengjing , Lin Zhenlang , Xu Baoji , Fu Xiaoqin
Published: May 2020

There are two major isoforms of NTRK2 (neurotrophic receptor tyrosine kinase 2, or TrkB), full-length isoform with tyrosine kinase (TK) domain intact (+) and spliced isoform without tyrosine kinase domain (TK(−)). Within each isoform, there exist subtypes with minor modifications of the protein sequences. In human, theNTRK2mRNA transcripts encoding TK(+) have same 3′UTRs, while the transcripts encoding subtypes of NTRK2 TK(−) have two completely different 3′UTRs. In mouse, the mRNA transcripts encoding same NTRK2 protein sequence for either TK(+) or TK(−) have long or short 3′UTRs, respectively. The physiological functions of these different 3′UTRs are still unknown. Pilocarpine stimulation increasedNtrk2mRNA levels in soma, while the increase in synaptosome was smaller. FISH results further showed that mouseNtrk2transcripts with different 3′UTRs were distributed differently in cultured cortical neurons. The transcripts with long 3′UTR were distributed more in apical dendrites compared with transcripts with short 3′UTR. Our results provide evidence of non-coding 3′UTR function in regulating mRNA distribution in neurons.
Attention deficit hyperactivity symptoms predict problematic mobile phone use
Authors: Panagiotidi Maria , Overton Paul
Published: May 2020

Attention-deficit-hyperactivity disorder (ADHD) is the most commonly diagnosed childhood disorder characterised by inattention, hyperactivity/impulsivity, or both. Some of the key traits of ADHD have previously been linked to addictive and problematic behaviours. The aim of the present study was to examine the relationship between problematic mobile phone use, smartphone addiction risk and ADHD symptoms in an adult population. A sample of 273 healthy adult volunteers completed the Adult ADHD Self-Report Scale (ASRS), the Mobile Phone Problem Usage Scale (MPPUS), and the Smartphone Addiction Scale (SAS). A significant positive correlation was found between the ASRS and both scales. More specifically, inattention symptoms and age predicted smartphone addiction risk and problematic mobile phone use. Our results suggest that there is a positive relationship between ADHD traits and problematic mobile phone use. In particular, younger adults with higher level of inattention symptoms could be at higher risk of developing smartphone addiction. The implication of our findings for theoretical frameworks of problematic mobile phone use and clinical practice are discussed.
Analysis and evaluation of the spatial and temporal variabilities of river water quality parameters
Authors: Shishaye Haile Arefayne , Asfaw Asmelash Tilahun
Published: May 2020

This study aimed to analyze the status and evaluate the spatiotemporal variabilities of water quality in the Awash River, Ethiopia. The study also aims to identify the origin and geochemical composition of the river water. Temporal variabilities of similar water quality parameters in the Lake Beseka, a dramatically rising lake (0.2 m/year) in the Awash River basin, which is being channeled into the Awash River system in order to control the lake level rise, were also considered in this study. To do this, laboratory measurements and a 10-year consecutive record of physicochemical parameters, major ions, nutrients and minor ions of the Awash River and Lake Beseka waters, graphical methods and factor analysis approaches were used. The origin of the Awash River was found to be shallow-medium depth aquifer with a geochemical composition of Ca(HCO3)2and NaHCO3, while the origin of Lake Beseka was found to be deep, ancient groundwater with a geochemical composition of NaCl and NaHCO3. However, mixing the lake water with Awash River in the downstream sites shifted the geochemical composition of the river water to a mixture of Ca(HCO3)2, NaHCO3and NaCl water types. The results also showed that the river water quality varies spatially and temporally, controlled by three major factors: the combined effects of anthropogenic activities and mineral dissolutions (Factor-1), anthropogenic activities and ion exchange (Factor-2) and ion exchange (Factor-3). While Factor-1 was the main controlling factor of the river water quality, and Factor-3 was the least, all three factors equally controlled the temporal variabilities of water quality in Lake Beseka. The observed temporal and spatial variabilities of the river water quality suggest that frequent water quality evaluations are important in designing appropriate water management strategies in river systems near intensive agricultural, industrial, and urban development areas.
Evaluation of the activated carbon coated with multiwalled carbon nanotubes in removal of ciprofloxacin from aqueous solutions
Authors: Sharifpour Narges , Moghaddam Fazel Mohammadi , Mardani Goshtasb , Malakootian Mohammad
Published: May 2020

Ciprofloxacin (CIP) is a commonly used antibiotic which is excreted in significant quantities and may likely be found in environments, especially wastewater. Thus, in the present study, we aimed to remove CIP from aqueous solutions using activated carbon supported with multivalent carbon nanotubes MWCNTs/AC. Herein, we prepared the MWCNTs/AC and the structural characterization of the adsorbent was performed using the BET, FTIR, and SEM methods. In order to obtain the optimal conditions of MWCNTs/AC activity, different experimental conditions including the pH, adsorbent dosage, contact time, initial CIP concentration, and temperature were examined. Afterward, to approach reality, the experiments were carried out under the optimal conditions using a sewage sample previously determined in terms of the BOD, COD, pH, EC, turbidity, and concentration of ciprofloxacin. Finally, the CIP levels were measured by HPLC. According to the results, the pH of 7, contact time of 30 min, adsorbent dosage of 20 mg/L, temperature of 40 °C, and initial CIP concentration of 20 mg/L were found to be the optimal conditions for MWCNTs/AC activity. In these conditions, the maximum removal efficiency of CIP from the synthetic and actual samples was 100% and 73%, respectively. Moreover, the adsorption behavior was in compliance with the pseudo-second-order, Freundlich isotherm kinetics. According to our findings, using MWCNTs/AC led to a considerable removal of CIP from the sewage samples. Thus, the use of this adsorbent is highly recommended in order to remove other antibiotics from water and wastewater.
The Examination of Diffusion Effects on Modern Contraceptive Use in Nigeria
Authors: Guilkey David K. , Escamilla Veronica , Calhoun Lisa M. , Speizer Ilene S.
Published: May 2020

This study uses data gathered for an evaluation of a Bill & Melinda Gates Foundation–funded initiative designed to increase modern contraceptive use in select urban areas of Nigeria. When the initiative was conceived, the hope was that any positive momentum in the cities would diffuse to surrounding areas. Using a variety of statistical methods, we study three aspects of diffusion and their effects on modern contraceptive use: spread through mass communications, social learning, and social influence. Using a dynamic causal model, we find strong evidence of social multiplier effects through social learning. The results for social influence and spread through mass communications are promising, but we are unable to identify definitive causal impacts.
Where Does Cumulative Culture Begin? A Plea for a Sociologically Informed Perspective
Authors: Haidle Miriam Noël , Schlaudt Oliver
Published: May 2020

Recent field studies have broadened our view on cultural performances in animals. This has consequences for the concept of cumulative culture. Here, we deconstruct the common individualist and differential approaches to culture. Individualistic approaches to the study of cultural evolution are shown to be problematic, because culture cannot be reduced to factors on the micro level of individual behavior (methodological individualism, “atomism”) but possesses a dynamic that only occurs on the group level and profoundly affects the individuals (“holism”). Naive individuals, as a prerequisite of an atomistic perspective, do not exist. We address the construction of a social approach to (cumulative) culture by introducing an inevitable social embedding of the individual development of social beings. The sociological notion of “habitus” as embodied cultural capital permits us to understand social transmission of behavioral components on a very basic level, resulting in a cumulative effect. Bits of information, movement, handling of material, attitudes, and preferences below distinct functional units are acquired through transfer mechanisms simpler than emulation and imitation such as peering, participation, co-performance, or engagement with a material environment altered by group members. The search for a zero point of cumulative culture becomes as useless as the search for a zero point of culture. Culture is cumulative.
Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events
Authors: Gülsen Askin , Wedi Bettina , Jappe Uta
Published: May 2020

Purpose

Biotechnological substances (BSs) are strongly relied upon to prevent rejection of transplanted organs, and to treat oncological, allergological, and other inflammatory diseases. Allergic reactions to partly foreign biologics can occur due to their potential immunogenicity. The severity of an immune response to a biological drug may range from no clinical significance to a severe, life-threatening anaphylactic reaction.

Methods

Detailed searches were performed on Pubmed, Web of Science, and Google Scholar to include all available publications. In addition, the Food and Drug Administration, the European Medicines Agency, and British Columbia Cancer Agency Drug Manual databases were screened for hypersensitivity reaction (HSR), infusion reaction, injection site reaction, urticaria, and anaphylaxis for individual BSs.

Results

Treatment with BSs can cause various types of HSR. These are mentioned in the literature with definitions such as allergic reactions, anaphylactoid reactions, anaphylaxis, HSR, infusion reactions, injection site reactions, cytokine release syndrome, and urticaria. Due to the overlap in signs and symptoms in the reported descriptions, it is not always possible to differentiate these reactions properly according to their pathomechanism. Similarly, many data reported as anaphylaxis actually describe severe anaphylactic reactions (grades III or IV).

Conclusion

There is an urgent need for a simpler symptom- or system-based classification and scoring system to create an awareness for HSRs to BSs. A better understanding of the pathophysiology of HSRs and increased clinical experience in the treatment of side effects will provide timely control of unexpected reactions. As a result, immunotherapy with BSs will become safer in the future.
Fidelity of Cyber-Physical Empirical Methods
Authors: Sauder T.
Published: May 2020

Cyber-physical empirical methods enable to address problems that classical empirical methods alone, or models alone, cannot address in a satisfactory way. In CPEMs, the substructures are interconnected through a control system that includes sensors and actuators, having their own dynamics. The present paper addresses how the fidelity of CPEMs, that is the degree to which they reproduce the behaviour of the real system under study, is affected by the presence of this control system. We describe an analysis method that enables the designer of a CPEM to (1) identify the artefacts (such as biases, noise, or delays) that play a significant role for the fidelity, (2) define bounds for the describing parameter of these artefacts ensuring high-fidelity of the CPEM, and (3) evaluate whether probabilistic robust fidelity is achieved. The proposed method is illustrated by considering a substructured slender structure subjected to dynamic loading.
Ethical judgement and intent in business school students: the role of the psyche?
Authors: Conway Elaine , Kotera Yasuhiro
Published: May 2020

The aim of this paper is to highlight how business schools can improve the ethical behaviour of future managers. It assesses the positions of ethical judgement and ethical intent within a sample of UK business students, together with an analysis of underlying explanatory factors to those positions, such as levels of depression, anxiety, stress, motivation and self-compassion. A range of scales were used to evaluate the ethical stance and psychological characteristics of a group of UK business students. The results indicate that feelings of self-compassion, a sense of self-direction and mental health (in particular, depression) affect the ethical judgement and intent of students in a range of business and university scenarios. It is recommended that in addition to more formal ethics education, universities consider the mental health and psyche of their students to improve the efficacy of ethical training.
Disclosure of Vlog Advertising Targeted to Children
Authors: De Jans Steffi , Hudders Liselot
Published: May 2020

Influencers can disclose vlog advertising by implementing a platform-generated disclosure or by generating their own disclosure. This study aims to investigate whether and how these two types of disclosures differentially affect children's responses toward the sponsored content and the influencer. To do so, a two (platform-generated [PG] disclosure: no PG disclosure versus PG disclosure) by three (influencer-generated [IG] disclosure: no IG disclosure versus no commercial interference disclosure versus commercial interference disclosure) between-subjects experimental study was conducted among 190 children (aged ten to twelve). The results show that both types of disclosures increased children's recognition of vlog advertising; however, children's advertising literacy (i.e. their understanding of influencer marketing and skepticism toward the ad) was less activated when the influencer specifically indicated that there was no commercial interference of the brand. In addition, besides being more beneficial for influencers (by not negatively affecting children's evaluations of the influencer), an IG disclosure also showed to be more favorable for brands, as it increased brand effects among children, whereas a PG disclosure decreased these brand effects.
Diagnosis and treatment of emergency surgeries in otorhinolaryngology, head and neck surgery during the covid‐19 outbreak: A single center experience
Authors: Sun Yu , Zhang Li , Cheng Qing , Hu Yujuan , Xiao Hongjun
Published: May 2020

The 2019 Novel Coronavirus (2019‐nCoV, SARS‐CoV‐2) infection has already been assigned as a Class B infectious disease requiring Class A management strategy according to “the Law on the Prevention and Control of Infectious Diseases of the People's Republic of China” and become a global pandemic. The incidence of emergencies in otorhinolaryngology, head and neck surgery such as foreign bodies in the esophagus and the respiratory tract, epistaxis, laryngeal obstruction with dyspnea, and head and neck trauma are relatively high. Emergency surgeries are required as some of these diseases progress rapidly and probably be life‐threatening. In this article, we drafted the recommendations for diagnosis and treatment of emergency surgeries in otorhinolaryngology, head and neck surgery in the epidemic area of novel coronavirus pneumonia based on “Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional; 7th Edition Revisions)”and WHO guidelines, combined with the experience of emergency surgeries in the Department of Otorhinolaryngology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, which is at the center outbreak area of the SARS‐CoV‐2 pneumonia (COVID‐19) in China, to improve the success rate of treatment for otorhinolaryngology, head and neck surgery emergency surgeries and to reduce the SARS‐CoV‐2 infection rate in the perioperative period.
The contrastive topic requirement on specificational subjects
Authors: Milway Daniel
Published: May 2020

This paper offers a discourse-pragmatic account of the constraint on indefinite DPs as subjects of specificational copular clauses (a doctor is Mary). Building on Mikkelsen's (2004) proposal that specificational subjects are topics, I argue that they must be contrastive topics whichproperlycontain F-marked constituents. I show that this can account for the absolute ban on simple indefinite subjects, and allow for more complex indefinites to be subjects. Finally, I discuss the syntactic analysis that would be predicted given my pragmatic analysis, and the puzzles that arise from it.
How to Reorganize the Radiology Departments to Face the 2019 Coronavirus Disease Outbreak
Authors: Cellina Michaela , Orsi Marcello , Oliva Giancarlo
Published: May 2020

Radiology departments have been directly involved from the beginning of the novel coronavirus disease (COVID-19) emergency to provide imaging lung assessment of suspected and positive patients while ensuring the execution of other routine and emergency examinations for non-COVID-19 patients. To limit the risk of the infection spread, radiology departments should be reconfigured. We propose the example of the reorganization of the Radiology Department of our hospital, in the center of Milan, in Northern Italy, which consisted of the creation of 2 completely distinct pathways and distinct radiological machines for COVID-19 positive or suspected positive and for non-COVID-19 patients.
From defence to offence: The ethics of private cybersecurity
Authors: Pattison James
Published: May 2020

The cyber realm is increasingly vital to national security, but much of cybersecurity is provided privately. Private firms provide a range of roles, from purely defensive operations to more controversial ones, such as active-cyber defense (ACD) and ‘hacking back’. As with the outsourcing of traditional military and security services to private military and security companies (PMSCs), the reliance on private firms raises the ethical question of to what extent the private sector should be involved in providing security services. In this article, I consider this question. I argue that a moderately restrictive approach should be adopted, which holds that private firms can justifiably launch some cybersecurity services – defensive measures – but are not permitted to perform others – offensive measures.
The Curious Case of Belgium: Why is There no Right-Wing Populism in Wallonia?
Authors: de Jonge Léonie
Published: May 2020

Why are populist radical right parties (PRRPs) more successful in some countries than in others? This question is analysed here by focusing on Belgium. While Flanders (the northern, Dutch-speaking part of Belgium) was home to one of the strongest far-right movements in Europe, Wallonia (the southern, francophone part) has remained ‘immune’ to such tendencies. The article argues that different historical experiences have given rise to a hostile political environment for PRRPs in Wallonia, where mainstream parties and the media have created a successful cordon sanitaire. In Flanders, mainstream parties and the media have gradually become more accommodative towards PRRPs. By emphasizing the sociopolitical context in which parties operate, the findings suggest that the reactions of mainstream parties and the media are crucial to understanding the success of PRRPs. The conclusion reflects on potential lessons to be drawn from the Belgian case for mainstream parties and media practitioners elsewhere.
Da alfândega ao Valongo: A entrada dos cativos africanos no Rio de Janeiro no século dezenove sob uma nova perspectiva historiográfica
Authors: Tavares Reinaldo Bernardes , Rodrigues-Carvalho Claudia , Lessa Andrea
Published: May 2020

Este artigo faz uma análise das práticas portuárias empregadas no comércio de africanos na cidade do Rio de Janeiro durante as duas primeiras décadas do século dezenove. A partir da diferenciação conceitual entre desembarque e descarga final das arqueações de cativos, novos dados obtidos em fontes primárias inéditas foram confrontados com relatos de cronistas e com fontes documentais tradicionalmente conhecidas. Sob essa perspectiva, o texto apresenta um panorama sólido e plausível sobre o processo de importação de escravizados, resgatando a importância do papel da alfândega do Rio de Janeiro como primeiro local de desembarque, e deslocando para o litoral da Saúde, no antigo bairro do Valongo, o local de descarga final das arqueações de africanos. Trata-se, portanto, de um cenário divergente da teoria corrente, segundo a qual o Cais do Valongo, localizado na enseada do Valonguinho, teria sido a porta de entrada dos milhares de cativos africanos que chegaram ao Rio de Janeiro.
Trial by Zoom? The Response to COVID-19 by Canada's Courts
Authors: Puddister Kate , Small Tamara A.
Published: May 2020

COVID-19 has made videoconferencing a regular occurrence in the lives of Canadians. Videoconferencing is being used to maintain social ties, run business meetings—and to uphold responsible government. On April 28, 2020, Members of the House of Commons sat virtually using Zoom. The virtual sitting was the first of what will become a stand-in for regular proceedings, allowing the Members to fulfill some of their parliamentary duties while complying with physical distancing (see Malloy, 2020). As the legislative and executive branches look to digital technology to allow the business of government to continue, what about the judicial branch of Canada's government? Courts are an essential service. This is best articulated by the Chief Justice of Nova Scotia: “The fact is, the Courts cannot close. As the third branch of government, an independent judiciary is vital for our Canadian democracy to function. It is never more important than in times of crisis” (Wood, 2020). In this analysis, we seek to understand how courts have responded to COVID-19 and the challenges of physical distancing through the use of digital technologies. This is accomplished through a systematic review of COVID-19 statements and directives issued from all levels of court across Canada. We briefly compare Canada to the United States, a jurisdiction that demonstrates greater openness to technology.
Variability in physiological responses of Venezuelan cacao to drought
Authors: Tezara Wilmer , Pereyra Gabriela , Ávila-Lovera Eleinis , Herrera Ana
Published: May 2020

In order to assess the response of cocoa trees to drought, changes in water status, gas exchange, leaf carbon isotopic ratio (δ13C), photochemical activity, and leaf N and chlorophyll content during the rainy and dry season were measured in 31 Venezuelan cocoa clones (17 Trinitarios, 6 Criollos, and 8 Modern Criollos) grown in a common garden. Drought caused a 40% decrease in water potential (ψ) in all but the Modern Criollos, and a reduction in net photosynthetic rate (A) and stomatal conductance (gs) without an increase in instantaneous water use efficiency (WUE) in 93% of clones, and an increase inδ13C (long-term WUE) in 74% of clones; these responses suggest differences in tolerance to drought among clones. A positive correlation betweenAand bothgsand leaf N content was found for all genotypes. Leaf N content, chlorophyll content, and photochemical activity were reduced during drought, suggesting that metabolism was also inhibited. The best performance during drought was shown by Modern Criollos with the highest WUE, while five Trinitario clones seemed to be less sensitive to drought, since neither chlorophyll, N, total soluble protein concentration, norgschanged with drought, indicating that those Trinitario clones, with lowerA, have a conservative water use. Modern Criollos showed no reductions in eitherψorgs;Aremained unchanged, as did WUE, which was the highest, suggesting that these clones would be more successful in environments with low water availability. Our results indicate large variation in physiological response to drought over a range of parameters, suggesting possible differences in tolerance among clones.
Ecto- and endoparasites of the King's skink (Egernia kingii) on Penguin Island
Authors: Stampe Karina , Larsen Ole Næsbye , Godfrey Stephanie S.
Published: May 2020

Wildlife species are often host to a diversity of parasites, but our knowledge of their diversity and ecology is extremely limited, especially for reptiles. Little is known about the host-parasite ecology of the Australian lizard, the King's skink (Egernia kingii). In spring of 2015, we carried out a field-based study of a population of King's skinks on Penguin Island (Western Australia). We documented five species of parasites, including two ectoparasitic mites (an undescribed laelapid mite and Mesolaelaps australiensis), an undescribed coccidia species, and two nematode species (Pharyngodon tiliquae and Capillaria sp.). The laelapid mite was the most abundant parasite, infesting 46.9% of the 113 captured lizards. This mite species increased in prevalence and abundance over the course of the study. Infection patterns of both mites varied with lizard life-stage; sub-adults were more commonly infested with laelapid mites than adults or juveniles, and sub-adults and adults were infested by more laelapid mites than juveniles. By contrast, adults had a higher prevalence of M. australiensis than juveniles or sub-adults. Among the gastrointestinal parasites, P. tiliquae was relatively common among the sampled lizards (35.3%). These results give new important information about reptiles as parasite hosts and what factors influence infection patterns.
ON RELIABILITY FUNCTION OF A K-OUT-OF-N SYSTEM WITH GENERAL REPAIR TIME DISTRIBUTION
Authors: Rykov Vladimir , Kozyrev Dmitry , Filimonov Andrey , Ivanova Nika
Published: May 2020

The reliability study of k-out-of-n systems is of interest both from theoretical and practical points of view. Applications of such models can be seen in many real-world phenomena, including telecommunication, transmission, transportation, manufacturing, and services. A probabilistic study of a real-world k-out-of-n system often helps to develop an optimal strategy for maintaining high system-level reliability. There are many investigations devoted to the reliability-centric analysis of such systems. We consider a mathematical model of a repairable k-out-of-n system that works until k of its n components have failed. During the system's life cycle, its components are repaired with the help of a single repair facility. It is supposed that the components' lifetimes have an exponential distribution and their repair times have a general distribution. The proposed model is intended to be applied to the description of operation of unmanned rotorcraft high-altitude platforms and to be validated with the help of an experimental prototype. For the considered system, we propose an algorithm for calculation of the reliability function, and for special cases, k = 2 and k = 3, its closed-form representation is given. A numerical investigation is performed for special cases. The obtained results are a first step toward the sensitivity analysis of reliability characteristics of k-out-of-n systems to the shape of the repair time distributions of their components.
Correlation between the migration scale index and the number of new confirmed coronavirus disease 2019 cases in China
Authors: Chen Huijie , Chen Ye , Lian Zhiyong , Wen Lihai , Sun Baijun , Wang Ping , Li Xinghai , Liu Qiong , Yu Xiaoyun , Lu Ying , Qi Ying , Zhao Shuo , Zhang Linlin , Yi Xiaodan , Liu Fengyu , Pan Guowei
Published: May 2020

In late December 2019, patients of atypical pneumonia due to an unidentified microbial agent were reported in Wuhan, Hubei Province, China. Subsequently, a novel coronavirus was identified as the causative pathogen which was named SARS-CoV-2. As of 12 February 2020, more than 44 000 cases of SARS-CoV-2 infection have been confirmed in China and continue to expand. Provinces, municipalities and autonomous regions of China have launched first-level response to major public health emergencies one after another from 23 January 2020, which means restricting movement of people among provinces, municipalities and autonomous regions. The aim of this study was to explore the correlation between the migration scale index and the number of confirmed coronavirus disease 2019 (COVID-19) cases and to depict the effect of restricting population movement. In this study, Excel 2010 was used to demonstrate the temporal distribution at the day level and SPSS 23.0 was used to analyse the correlation between the migration scale index and the number of confirmed COVID-19 cases. We found that since 23 January 2020, Wuhan migration scale index has dropped significantly and since 26 January 2020, Hubei province migration scale index has dropped significantly. New confirmed COVID-19 cases per day in China except for Wuhan gradually increased since 24 January 2020, and showed a downward trend from 6 February 2020. New confirmed COVID-19 cases per day in China except for Hubei province gradually increased since 24 January 2020, and maintained at a high level from 24 January 2020 to 4 February 2020, then showed a downward trend. Wuhan migration scale index from 9 January to 22 January, 10 January to 23 January and 11 January to 24 January was correlated with the number of new confirmed COVID-19 cases per day in China except for Wuhan from 22 January to 4 February. Hubei province migration scale index from 10 January to 23 January and 11 January to 24 January was correlated with the number of new confirmed COVID-19 cases per day in China except for Hubei province from 22 January to 4 February. Our findings suggested that people who left Wuhan from 9 January to 22 January, and those who left Hubei province from 10 January to 24 January, led to the outbreak in the rest of China. The ‘Wuhan lockdown’ and the launching of the first-level response to this major public health emergency may have had a good effect on controlling the COVID-19 epidemic. Although new COVID-19 cases continued to be confirmed in China outside Wuhan and Hubei provinces, in our opinion, these are second-generation cases.
Legal Disputes Involving Clergy Discipline: Perspectives from Nigeria and South Africa
Authors: Akinloye Idowu A
Published: May 2020

To preserve the integrity and purity of the church, the policies of churches commonly provide for the enforcement of discipline whenever a cleric errs. The concern is that despite these provisions in the governing documents of churches, disputes challenging churches’ disciplinary exercise over their clergy are increasingly finding their way into the civil courts for adjudication. These disputes have implications for the reputation, governance and flourishing of a church. Against this backdrop, this article analyses a number of case studies to examine some legal issues arising from the churches’ exercise of disciplinary powers over their clergy within the Nigerian and South African contexts. From the analysis of the cases, a wide variety of legal issues associated with implementing church disciplinary procedures are identified to offer some lessons that may enhance the quality of legal risk management for churches.
Paucity of renal follow-up by school age after neonatal cardiac surgery
Authors: Rodriguez-Lopez Sara , Huynh Louis , Benisty Kelly , Dancea Adrian , Garros Daniel , Hessey Erin , Joffe Ari , Mackie Andrew , Palijan Ana , Paun Alex , Pizzi Michael , Riglea Teodora , Zappitelli Michael , Morgan Catherine
Published: May 2020

Introduction:

There are little data about renal follow-up of neonates after cardiovascular surgery and no guidelines for long-term renal follow-up. Our objectives were to assess renal function follow-up practice after neonatal cardiac surgery, evaluate factors that predict follow-up serum creatinine measurements including acute kidney injury following surgery, and evaluate the estimated glomerular filtration rate during follow-up using routinely collected laboratory values.

Methods:

Two-centre retrospective cohort study of children 5–7 years of age with a history of neonatal cardiac surgery. Univariable and multivariable analyses were performed to determine factors associated with post-discharge creatinine measurements. Glomerular filtration rate was estimated for each creatinine using a height-independent equation.

Results:

Seventeen of 55 children (30%) did not have any creatinine measured following discharge after surgery until the end of study follow-up, which occurred at a median time of 6 years after discharge. Of the 38 children who had the kidney function checked, 15 (40%) had all of their creatinine drawn only in the context of a hospitalisation or emergency department visit. Acute kidney injury following surgery did not predict the presence of follow-up creatinine measurements.

Conclusions:

A large proportion of neonates undergoing congenital heart repair did not have a follow-up creatinine measured in the first years following surgery. In those that did have a creatinine measured, there did not appear to be any identified pattern of follow-up. A follow-up system for children who are discharged from cardiac surgery is needed to identify children with or at risk of chronic kidney disease.
Critical Care Surge Capacity to Respond to the COVID-19 Pandemic in Italy: A Rapid and Affordable Solution in the Novara Hospital
Authors: Cammarota Gianmaria , Ragazzoni Luca , Capuzzi Fabio , Pulvirenti Simone , De Vita Nello , Santangelo Erminio , Verdina Federico , Grossi Francesca , Vaschetto Rosanna , Della Corte Francesco
Published: May 2020

The rapid insurgence and spread of coronavirus disease 2019 (COVID-19) exceeded the limit of the intensive care unit (ICU) contingency plan of the Maggiore della Carità University Hospital (Novara, Italy) generating a crisis management condition. This brief report describes how a prompt response to the sudden request of invasive mechanical ventilation (IMV) was provided by addressing the key elements of health care system surge capacity from contingency to crisis. In a short time and at a relatively low cost, a structural modification of a hospital aisle allowed to convert the general ICU into a COVID-19 unit, increasing the number of COVID-19 critical care beds by 107%.
Outcome in depression (II): beyond the Hamilton Depression Rating Scale
Authors: Demyttenaere Koen , Kiekens Glenn , Bruffaerts Ronny , Mortier Philippe , Gorwood Philip , Martin Lorcan , Di Giannantonio Massimo
Published: May 2020

Background

The Leuven Affect and Pleasure Scale (LAPS) was developed as an outcome measure in major depressive disorder (MDD) tha treflects patient treatment expectations. The present report investigates whether the LAPS negative affect, the LAPS positive affect, and the LAPS hedonic tone have added value on top of the Hamilton Depression Rating Scale (HAMD) in explaining generic as well as patient-centered outcomes.

Methods

A total of 109 outpatients with Diagnostic and Statistical Manual of Mental Disorders, fifth edition, criteria for MDD were assessed over 8 weeks of antidepressant treatment. At baseline and after 2, 4, and 8 weeks, the LAPS, HAMD, Snaith–Hamilton Pleasure Scale (SHAPS), Positive and Negative Affect Scale (PANAS), and Sheehan Disability Scale were administered. The Clinical Global Impression of Improvement (CGI-I) and the Patient Global Impression of Improvement (PGI-I) were also administered at endpoint.

Results

Changes in LAPS negative affect, LAPS positive affect, and LAPS hedonic tone explain 14% of the additional variance in CGI-I, 21% in PGI-I, 37% in cognitive functioning, 32% in overall functioning, 31% in “my life is meaningful,” and 45% in “I feel happy.” Compared to standard scales (PANAS and SHAPS), the LAPS negative affect, LAPS positive affect, and LAPS hedonic tone differentiate better between different levels of CGI-I or PGI-I.

Conclusions

The LAPS has added value (on top of the HAMD) in explaining changes in both generic outcomes (CGI-I/PGI-I) and patient-centered dimensions. The LAPS negative and positive affects and the LAPS hedonic tone differentiate CGI-I and PGI-I scores better than corresponding scales supposed to cover the same domains.
Effect of deliberation style on the gender gap in deliberative participation
Authors: Levy Hiroko Ide , Sakaiya Shiro
Published: May 2020

The importance of citizen deliberation in democracy is widely recognized today and the current digitalized and more fragmented society may benefit from discussions among people with diverse opinions in a well-organized setting. At the same time, concerns have also been raised about inequality in deliberative participation. We narrowed our focus to gender equality and examined whether introducing an evidence-driven style of deliberation can mitigate gender inequality in policy deliberation. In our repeated measure (within-subjects) experiment, university students in Japan discussed divisive policy issues during two sessions. Half of the participants started the discussion by examining factual information about the topic (evidence-driven style) and the other half started the discussion by expressing opinions about the topic (verdict-driven style). In the second session, the two groups switched styles. We found a statistically significant gender gap in participatory contribution for the verdict-driven style, but no such gap existed for the evidence-driven style. Using causal mediation analysis, we also found that, compared with the verdict-driven style, the evidence-driven style of deliberation reduces the gender gap by lowering women's tendency to agree with men. One possible explanation from the viewpoint of gendered communication is that women were more confident in evidence-driven deliberations. This psychological effect is a factor that is harder for facilitators to control and thus the evidence-driven style can be effective even with the presence of facilitators. This paper demonstrates the importance of studying how deliberations are conducted and how deliberation styles can affect the content and the consequences of policy deliberations.
“Whig Thomism” and the Making of the Catholic Neoconservative Movement
Authors: Russell Jesse
Published: May 2020

The writings of St. Thomas Aquinas, although widely noted for their clarity, are also rich and capacious enough to merit differing interpretations among scholars of good will and good faith. However, despite the noble intentions and praiseworthy work of the late Michael Novak and other Catholic neoconservatives, their marketing of St. Thomas Aquinas as the “first Whig” appears to sever elements of the Angelic Doctor's philosophy from its essential principles. Although jealously guarding the nobility of conscience and the interior life, St. Thomas envisioned a political community that was decidedly hierarchical and in which the faith was to be shepherded by the state, which itself was charged with suppressing heresy and dissident thinking. These political ideas, moreover, are rooted in the very heart of St. Thomas Aquinas's deepest philosophical and theological principles.
Impact of Leuconostoc SD23 intake in obese pregnant rats: benefits for maternal metabolism
Authors: Castro-Rodríguez Diana C. , Juárez-Pilares Gimena , Cano-Cano Luz , Pérez-Sánchez Mariana , Ibáñez Carlos A. , Reyes-Castro Luis A. , Yáñez-Fernández Jorge , Zambrano Elena
Published: May 2020

Maternal obesity (MO) during pregnancy and lactation leads to maternal and offspring metabolic dysfunction. Recent research has suggested that probiotics might be a novel approach to counteract these unwanted MO effects. The aim of this research was to analyze the impact of Leuconostoc SD23, a probiotic isolated from aguamiel (traditional Mexican drink), on MO metabolism in rats at the end of lactation (21 days). From weaning through lactation, control female Wistar rats (C) ate chow (5% fat) or high-energy obesogenic diet (MO; 25% fat). Half the C and MO mothers received a daily dose (1 × 1010 CFU/ml) of probiotic orally, control with probiotic (CP) and MO with probiotic (MOP), 1 month before mating and through pregnancy and lactation. Histological analyses of the liver, white adipose tissue and small intestine, body composition, glucose, insulin, triglycerides, and leptin were determined in mothers at the end of lactation. Maternal weight during pregnancy was greater in MO than C mothers, but similar at the end of lactation. Probiotic intervention had no effect on maternal weight. However, at the end of lactation, percentage of body fat was higher in MO than C, CP, and MOP. Serum glucose, homeostasis model assessment of insulin resistance, and triglycerides were higher in MO versus C, CP, and MOP. MO small intestine villus height was higher versus MOP, C, and CP. Leuconostoc SD23 did not present adverse effects in C. Conclusions: maternal administration of Leuconostoc SD23 has beneficial effects on maternal metabolism, which holds possibilities for preventing adverse offspring metabolic programming.
The Barbarians Are at the Gate!
Authors: Hatemi Pete
Published: May 2020

Nicholas Martin’s contribution to science is well known. This article reviews one small part of his pioneering work that integrated political and social attitudes with behavior genetics. Nick Martin, in part, led to a paradigm shift in the social sciences, and in political science in particular. These fields were previously wed to behavioralist approaches and now routinely include genetic influences in both theoretical and empirical study. This article also celebrates a part of Nick’s contribution that many do not know. Nick Martin does not just build science, he builds scientists. There are many who would not be academics or scholars without Nick’s guidance, mentorship and friendship. This review was written to express the deepest appreciation for what he has done and continues to do for science and the scientist.
Contributions of Nicholas Martin to Gambling Disorder Research
Authors: Slutske Wendy S. , Lind Penelope A.
Published: May 2020

Professor Nicholas G. Martin, from QIMR Berghofer Medical Research Institute in Brisbane, Australia, is a world leader in the effort to understand the genetic architecture underlying disordered gambling. This article pays tribute to Nick and his almost two decades of gambling research, highlighting his many strengths, ranging from the use of ingenious recruitment approaches, twin study methods, genomewide association studies, to facilitating international collaborations.
The Surge of the Hispar Glacier, Central Karakoram: SAR 3‐D Flow Velocity Time Series and Thickness Changes
Authors: Guo Lei , Li Jia , Li Zhi‐wei , Wu Li‐xin , Li Xin , Hu Jun , Li Hui‐lin , Li Hong‐yi , Miao Ze‐lang , Li Zhong‐qin
Published: May 2020

The Hispar Glacier is a useful site for studying surge mechanisms. Prior to this study, only two‐dimensional (2‐D) flow velocities having low temporal resolution were available for this glacier, providing inadequate information about its surge evolution. In this study, 139 synthetic aperture radar (SAR) images from Sentinel‐1A were used to obtain 3‐D flow velocity time series for the Hispar Glacier during the recent surge (2014–2016). The 3‐D flow velocities were sampled at an interval of 11 days, which is much greater than in previous studies. Besides, the Shuttle Radar Topography Mission (SRTM) digital elevation model (DEM) and two TanDEM‐X images were used to determine glacier thickness changes prior to and following the recent surge. Combining the results and geomorphologic features, we deduced that the recent surge was because of saturated basal water pressure in the Yutmaru tributary. The mass from the Yutmaru tributary squeezed into the trunk and rapidly flowed downslope along the northern margin, generating strong normal pressure to the trunk mass. Pushed by the Yutmaru tributary, the trunk began to surge in September 2014. The flow velocity reached a first peak in May 2015 and then decreased in October 2015, as part of the basal meltwater ran off. However, basal meltwater accumulated again during the following 4 months, and correspondingly, the trunk accelerated again after October 2015. Finally, as kinetic energy was released and resisting force increased, the trunk became almost stagnant in August 2016. The surge mass was blocked downstream in the trunk by the mass transferred from the Kunyang tributary, and consequently, the glacier did not advance.
Seasonal and Coseismic Velocity Variation in the Region of L'Aquila From Single Station Measurements and Implications for Crustal Rheology
Authors: Poli Piero , Marguin Valentin , Wang Qingyu , D'Agostino Nicola , Johnson Paul
Published: May 2020

We performed measurements of velocity variations for variable coda waves time lapse using empirical Green's functions reconstructed by autocorrelation of seismic noise recorded during a period of 17 years in the region of L'Aquila, Italy. The time lapse approach permitted us to evaluate the spatial (depth) dependence of velocity variation (dv/v). By quantitatively comparing the 17 years of dv/v time series with independent data (e.g., strain induced by earthquakes and hydrological loading), we unravel a group of physical processes inducing velocity variations in the crust over multiple time and spatial scales. We find that rapid shaking due to three magnitude 6+ earthquakes mainly induced near surface velocity variations. On the other hand, slow strain perturbation (period 5 years, in the preseismic period) associated with hydrological cycles, induced velocity changes primarily in the middle crust. The observed behavior suggests the existence of a large volume of fluid‐filled cracks exist deep in the crust. Our study highlights the possibility of using seasonal and multiyear perturbations to probe the physical properties of seismogenic fault volumes and shed new light into the depth‐dependent rheology of crustal rocks in the region or L'Aquila.
Source Regions of Infragravity Waves Recorded at the Bottom of the Equatorial Atlantic Ocean, Using OBS of the PI‐LAB Experiment
Authors: Bogiatzis P. , Karamitrou A. , Ward Neale J. , Harmon N. , Rychert C. A. , Srokosz M.
Published: May 2020

Infragravity waves are generated along coasts, and some small fraction of their energy escapes to the open oceans and propagates with little attenuation. Due to the scarcity of deep‐ocean observations of these waves, the mechanism and the extent of the infragravity waves energy leakage from the coasts remains poorly understood. Understanding the generation and pathways of infragravity wave energy is important among others for understanding the breakup of ice‐shelves and the contamination of high‐resolution satellite radar altimetry measurements of sea level. We examine data from 37 differential pressure gauges of Ocean Bottom Seismometers (OBS) near the equatorial mid‐Atlantic ridge, deployed during the Passive Imaging of the Lithosphere‐Asthenosphere Boundary (PI‐LAB) experiment. We use the beamforming technique to investigate the incoming directions of infragravity waves. Next, we develop a graph‐theory‐based global back‐projection method of noise cross‐correlation function envelopes, which minimizes the effects of array geometry using an adaptive weighting scheme. This approach allows us to locate the sources of the infragravity energy. We assess our observations by comparing to a global model of infragravity wave heights. Our results reveal strong coherent energy from sources and/or reflected phases at the west coast of Africa and some sources from South America. These energy sources are in good agreement with the global infragravity wave model. In addition, we also observe infragravity waves arriving from North America during specific events that mostly occur during October–February 2016. Finally, we find indications of waves that propagate with little attenuation, long distances through sea ice, reflecting off Antarctica.