bluuebunny/crossref_metadata_2025 huggingface dataset:
The Quality of Life and its Relationship to Psychological Burnout of Faculty Members in Saudi Universities
Authors: Al-Mulla Mazen Omer , Musa Montasir Kamal Al-Din Mohammed
Published: August 2024

The current study aimed to identify the quality of life and its relationship to psychological burnout among faculty members in Saudi universities. The study sample consisted of faculty members in Saudi universities (male and female) in scientific and literary specializations with their various academic degrees in the academic year (2022-2023), whose numbers (202) were chosen randomly. The study used the Quality of Life Scale (1996), prepared by the World Health Organization, based on the psychological burnout of Maslach (1986), and the data was transcribed and statistical processing was performed using the Statistical Package for Social Sciences software. The study reached the following results: The presence of a positive correlation between the quality of life and its relationship to psychological burnout among faculty members in Saudi universities, there was a non-significant decrease in the quality of life among faculty members in Saudi universities. The high level of psychological burnout among faculty members in Saudi universities and the presence of statistically significant differences in the quality of life and its relationship to psychological burnout among faculty members in Saudi universities were attributed to the gender variable in favor of females and the academic rank variable in favor of assistant professors, and the absence of differences in the quality of life among faculty members. In Saudi universities, the variables of academic specialization (scientific, literary), the university and the marital status were not available.
Exploring the Intersection of Religion and Cinema: Trends and Reflections in Contemporary Film Culture
Authors: Linze Li , Desa M. Asyiek Mat
Published: August 2024

This article delves into the complex relationship between religion and film, and studies the latest trends and ethical reflections in the field of film culture. Through an interdisciplinary perspective, this article explores how movies serve as a medium for communication between audiences and religion. By paying attention to the use of religious symbols and themes in movies, audiences are invited to reflect on spiritual themes and religious culture. The analysis of the social response of religious expressions in movies highlights the interactive relationship between social beliefs, cultural backgrounds, and religious narratives. This study focuses on the rich and diverse interpretations of religious themes in global film works by showcasing different depictions of religious elements in global films. In addition, the study also explored the role of film festivals as active platforms for religious dialogue and cross-cultural exchange, promoting a deeper understanding of religious diversity in contemporary society. The article also showcases the constantly evolving trend of religion in movies, as well as the ongoing academic enthusiasm for the ethical significance of depicting religious elements in movies.
Same-Sex Marriage from the Perspective of Legal Instruments, Human Rights and Hindu Religion
Authors: Putrawan I Nyoman Alit , Widnyana I Made Adi
Published: August 2024

The purpose of this research is to analyse the anti-discrimination struggle against LGBT from a legal and human rights perspective and same-sex marriage from a Hindu legal perspective. This research is normative juridical research carried out using a statutory regulation approach and a legal concept approach. The analysis was carried out qualitatively. The phenomenon of same-sex marriage has indeed become controversial in various countries, including Indonesia. The struggle for anti-discrimination treatment for LGBT people has become one of the focuses of the human rights struggle. Various national and international legal instruments have regulated the right to equal treatment for everyone. However, this right cannot fully become the basis for legitimacy for the legality of same-sex marriage. Law Number 1 of 1974 concerning Marriage regulates that marriage is carried out by a man and a woman as husband and wife. Viewed from the perspective of Hindu law, the Manawa Dhramasastra states that marriage is carried out by a man and a woman to produce offspring.
Theoretical Prerequisites for the Application of Interactive and Active Methods of English Language Instruction in Distance Learning
Authors: Saurbayev Rishat , Dauletmuratova Mexriban , Satylkhanova Gulmira , Nazarova Gaziza , Yerekhanova Fatima
Published: August 2024

This article examines the theoretical prerequisites for the use of active, and interactive methods of teaching English in the conditions of distance learning. The analysis of literary sources and the semantic understanding of the content of the research topic made it possible to develop a methodological apparatus for distance learning. The research objective of the article: theoretical justification of the use of active and interactive methods of teaching English in the conditions of distance learning. The object of the study is the process of distance teaching of the English language. The subject of the study is the use of active and interactive methods of distance teaching of English. Within the framework of the study, the following hypothesis is put forward if digital means are used in the process of distance teaching as an important condition of a distance learning system. It is necessary to take into account their content components, and the relationship with the taxonomy of learning goals, and learning experience, since this will reflect the activity, and interactivity of teaching English in distance learning.
A Review of Feminist Legal Theory on Abortion Regulations for Rape Victims in Indonesia
Authors: Asyrof Muhammad Fiqri , Lukmanula Fikri Rizki , Arya Mohammad , Asmara Teddy , Noupel Muhammad
Published: August 2024

The purpose of this study is to review and evaluate abortion regulations for rape victims, especially the requirements outlined in the Health Law and Government Regulation No. 61 of 2014 concerning Reproductive Health, using feminist legal theory as an analysis framework. This study uses an extra-doctrinal methodology outside the laws and regulations, emphasizing feminist legal theory as the basis of thought. The findings suggest that abortion regulations for rape victims still largely ignore women's life experiences and put them in difficult situations. The marginalization of women victims of rape in accessing safe abortion is a consequence of the gestational age limit for abortion, which fails to acknowledge the different experiences of women and treat them as a homogeneous group. To effectively address this issue, it is critical to involve the participation of women who have experienced rape, including victims of sexual violence, in the development of policies related to abortion for rape victims.
Mengoptimalkan Promosi yang Efektif untuk Penerimaan Siswa Baru Sekolah Kuncup Melati di Semarang
Authors: Masine Slahanti  , Rini Indah Sulistyowati  , Sofyandanu Setiadi
Published: August 2024

Kuncup Melati School consists of Kindergarten, Elementary School and Junior High School is one of the private schools located in the middle of the city which is quite strategic and very easy to access and in a densely populated area. In addition to being in a strategic and densely populated location, this school is a private school that does not charge any fees to its students. Funded by a Khong Kauw Hwee Foundation.Every year like other private schools, it opens registration opportunities, but even though the school is free, there are not many students, especially the community in the school environment, the school already has social media which is a means of information and promotion of activities and activities from the school, but registrants who enter this school sometimes do not meet the quota provided by the school. On this occasion, the Community Service Team will carry out activities with the theme of optimizing effective promotional media that can help achieve the target of students who register at Kuncup Melati School. , namely with promotional activities other than social media can be done with other media. The hope is that with this promotional optimization activity, it can increase public interest in entering school at Kuncup Melati.
Implementasi Strategi Pemasaran Digital Melalui E-Commerce Shopee pada UMKM Keripik Putri Sari Desa Wonokerto
Authors: Moch Rizky Khairul Rachman  , Yanda Bara Kusuma
Published: August 2024

It cannot be denied that the digital era has developed greatly in today's society, especially among teenagers. All groups from children to the elderly are technologically literate because the world has begun to evolve. This allows people to enjoy and maintain their motivation in following existing technological developments, including the fields of social media and e-commerce which cannot be separated from the Internet. Media advertising using Internet technology or other technological media is commonly referred to as e-commerce, which has the advantage of being able to carry out buying and selling activities between sellers, and applications using Internet technology to make online purchases. Usually, the e-commerce widely used by business players is Shopee.The appearance of the website is attractive and easy to understand, which is an important thing for the public to pay attention to in e-commerce. Nowadays, small and medium-sized business stakeholders are beginning to realize that society is showing more interest in online shopping, as consumers are also embracing the development of digital pursuit technology and no longer need to go to a shopping place to get the goods they want, what is offered in e-commerce is no less competitive
Meningkatkan Kemampuan Penghitungan Matematika Anak Tk Melalui Permainan Edukatif Dan Strategi Pembelajaran Yang Menyenangkan(Studi kasus TK Muslimat NU 34, Desa Silirejo, Tirto, Kab. Pekalongan)
Authors: Khoirunisa Indah , Dea Syakiroh Maghfirotun Nisa  , Putri Salsabila  , Ade Gunawan  , Ria Anisatus Sholihah  , Hendri Hermawan Adinugraha
Published: August 2024

Anak-anak usia dini cenderung memiliki minat yang rendah terhadap matematika karena kurangnya daya tarik dalam metode pengajaran yang konvensional. Metode pengajaran yang terlalu teoritis dan kurang interaktif sering kali membuat anak-anak merasa bosan dan sulit memahami konsep-konsep dasar matematika. Kegiatan pengabdian ini bertujuan untuk meningkatkan kemampuan penghitungan matematika pada anak usia dini dengan menciptakan lingkungan belajar yang menyenangkan guna merangsang dan menghibur bagi anak-anak TK. Metode yang digunakan dalam pengabdian ini ialah dengan menggunakan metode edukasi dan pelatihan kepada anak-anak di TK Muslimat NU 34. Setelah melaksanakan pengabdian dapat disimpulkan bahwa Pengabdian di TK Muslimat NU 34, Desa Silirejo, Tirto Kabupaten Pekalongan, terdapat 70% anak-anak yang mendengarkan dan memahami pembelajaran yang telah dipaparkan oleh pemateri, selanjutnya 15% anak-anak yang berlarian saat pembelajaran, 10% anak-anak yang bermain sendiri dan 5% anak-anak yang menangis saat pembelajaran dilaksanakan. Kemampuan tentang berhitung pada anak-anak dapat dilihat bahwa anak-anak 80% sudah bisa berhitung secara benar.
PERAN GURU PENDIDIKAN AGAMA ISLAM DALAM MENANAMKAN PENDIDIKAN KARAKTER RELIGIUS BERBASIS ASWAJA DI MADRASAH ALIYAH MA’ARIF SUKOREJO
Authors: Nirmawati Alfani Apriliani , Mohtarom Ali , Ma’ruf Ahmad , Yusuf Wiwin Fachrudin
Published: August 2024

The role of Islamic Religious Education teachers in instilling religious character in students at Madrasas which aims to increase the cultivation of religious characters through religious activities at their Madrasas. The purpose of this study was to determine the meaning of ASWAJA-based religious character education, to determine the role of Islamic Religious Education educators in instilling ASWAJA-based religious character education at Madrasah Aliyah Ma'arif Sukorejo and to determine the supporting and inhibiting factors of the role of Islamic Religious Education teachers in instilling ASWAJA-based religious character education at Madrasah Aliyah Ma'arif Sukorejo. In this study, the researcher used a qualitative descriptive approach, in which the descriptive meaning itself is a formulation of the problem that becomes a research guide for exploring or photographing social situations that will be thoroughly, broadly and in-depth examined. Data collection is done through observation, interviews and documentation. Then the data is analyzed with stages of data collection, data reduction, data presentation and conclusions. In order to ensure the validity of the data, triangulation of sources and methods is used. The results of the study show that the teacher seeks to instill Religious Character Education in students by carrying out religious teaching activities every day at Madrasah, the role of the teacher as a facilitator, motivator, and inspirer, evaluator, then the process of cultivating religious character at Madrasa Aliyah Ma'arif Sukorejo has supporting and inhibiting factors that come from the conditions of the students themselves and their environment, including the family environment, community and friendship environment.
EKSISTENSI PENGALIHAN PENANGGUNGJAWABAN MENCARI NAFKAH TERHADAP ISTRI MENURUT PERSPEKTIF ILMU FIKIH DAN ILMU PSIKOLOGI
Authors: Nisa Syaifi Udzkhiyatin , Muhtadin Sabilul
Published: August 2024

Marriage is a way to form a family with sacred ties and based on religious teachings. The existence of this marriage bond will give rise to rights and obligations. Among the duties of a wife are to obey her husband and maintain his honor. Meanwhile, the husband's obligations include the obligation to provide maintenance. Brebes is the second largest district in Central Java Province. This research aims to determine and analyze the impact of the transfer of earning a living on the wife, the factors causing it and the law on the transfer of earning a living from the perspective of Islamic jurisprudence and psychology. This research uses a qualitative approach with a case study type. The results of this research show that: (1) there are 4 negative impacts and 2 positive impacts experienced by the transfer of responsibility for earning a living to wives in Brebes District, (2) there are 4 factors that cause wives to choose to earn a living in Brebes District, ( 3) The transfer of responsibility for earning a living to the wife gives rise to laws in jurisprudence based on several circumstances and also the existence of a wife who plays a dual role can affect marital and family harmony, as well as affect the wife's mental condition.
PENGELOLAAN WAKAF TUNAI OLEH AZISWA DI PONDOK PESANTREN USHULUDDIN LAMPUNG SELATAN
Authors: Alfikri Ahmad
Published: August 2024

Ushuluddin Islamic Boarding School in South Lampung is still not yet qualified for a nadzir. Article 6 paragraph (3) of Government Regulation No. 28 of 1977, that nadzir must be registered at the Religious Affairs Office of the local sub-district for approval. This purpose is to find out the state of the relationship between one thing and another, especially causal relationships. This type of research is field research with a case study approach. Data collection is done through observation, interviews and documentation. Data wetness using source and method triangulation. The results showed that the Nadzir in the Ushuluddin Islamic Boarding School in South Lampung was legal according to Shari'ah, but not in accordance with applicable legislation. So that the management of cash waqf at the Ushuluddin Islamic Boarding School in South Lampung is legal according to the provisions of Shari'ah, but when viewed according to the applicable laws there are still some cash waqf implementations that are not appropriate.
OTORITAS FATWA KEAGAMAAN DALAM KONTEKS ERA KECERDASAN BUATAN (ARTIFICIAL INTELLIGENCE/AI)
Authors: Hakim Lukman , Azizi Muhamad Risqil
Published: August 2024

There is almost no line of life that is not possessed by artificial intelligence, including in the religious field. Islamic information, including religious fatwas can now be obtained quickly, easily, and abundantly by Muslims with the help of artificial intelligence technology. This poses an ethical problem when artificial intelligence algorithms shift religious authorities. This paper specifically discusses the views of (a) Islam about the presence of artificial intelligence technology and (b) questions religious fatwas from artificial intelligence using a normative approach with literature data. From this paper it is obtained that seeing the positive and negative impacts contained in the use of artificial intelligence, the Islamic view in this case is in a position of conflict on the one hand and reconciliation on the other when faced with artificial intelligence technology. As for fatwas obtained from artificial intelligence, in general it cannot be the only source to be taken as a legal opinion that is followed because of its anonymity (majhul al-hal). Thus, Muslims must still refer to credible religious authorities established or legalized by local authorities.
PERLINDUNGAN PEREMPUAN PADA PENERAPAN SANKSI PIDANA HUKUM KELUARGA DALAM ADMINISTRATION OF MUSLIM LAW ACT 1966 SINGAPURA
Authors: Rahmah Muftihatu
Published: August 2024

This article discusses the protection of women based on the Convention on the Elimination of All Forms of Discrimination against Women (CEDAW) in the application of criminal sanctions under the Administration of Muslim Law Act 1966 (AMLA) in Singapore. The research aims to analyze to what extent criminal sanctions in Islamic family law in Singapore have met the standards of women's protection set forth by CEDAW. This study employs a literature review approach using a gender justice perspective on women's protection as defined by CEDAW. The research findings indicate that the implementation of criminal sanctions under AMLA represents a significant step in safeguarding women. The criminal sanctions applied within AMLA provide legal assurance for women who experience violations within the context of family law, such as domestic violence, unlawful marriages, or the neglect of women's rights in divorce.
PERAN MATHLA’UL ANWAR MEMBENDUNG KAPITALISME PENDIDIKAN
Authors: Bahri Saepul , Muhajir Muhajir
Published: August 2024

This study aims to analyze the role of Mathla'ul Anwar in efforts to stem the influence of capitalism in the education system in Indonesia. This type of research is qualitative, drawing on the role of Mathla'ul Anwar in stemming the influence of capitalism in the education system. Data collection was conducted through observation, in-depth interviews, and documentation. Data analysis is carried out through data collection, data presentation and conclusions, while data maturity uses source triangulation. The results show that education can shape the character and develop the potential of the younger generation, carried out through strict supervision measures, emphasis on quality and values, and the provision of scholarships and Mathla'ul Anwar has become the forefront in protecting the integrity of education.
STUDI REALITAS WANITA KERIER DALAM MEWUJUDKAN KELUARGA SAKINAH DALAM MASYARAKAT MODERN
Authors: Pratama Nopi , Wijaya Asep
Published: August 2024

The existence of global changes from the agrarian era to the industrial era and even now into the information technology era, one of which has an impact on the shift in gender relations patterns. This is characterized by many women switching to the public sector or becoming career women in the hope of improving their family's economic status. The research aims to look at social changes related to career women in modern society in their role as contributors to the family economy, to create family harmony from the sociological perspective of Islamic law. The type of research used in this research is descriptive qualitative research. Through a normative-sociological approach. With data collection techniques through observation, interviews and documentation. Analysis of this research data through data reduction, data presentation, and concluding. Discussion result; 1) In the modern era, women are required to think forward and adapt to the climate of globalization and industrialization which has encouraged and spurred competency fluctuations in the world of work. 2) jobs taken by women who want to pursue a career in the public sector must also be based on family interests and by Islamic religious law. 3) To create more harmonious families in the modern era, a strong foundation of partnership between husbands and husbands is needed. and wife, complement and complement each other, and are balanced in economic terms.
ABOUT STUDENTS’ DIGNITY AT SECONDARY SCHOOL
Authors: Əmirxanzadə Günel
Published: August 2024

The article deals with educating pupils’ dignity, creating honour, dignity, pride, honesty, proud, courage in growing generation. Thus for methods of using these values have been researched in the literature textbook of 5-9 th grades, have been applied for prominent scientists’ thoughts, and given samples from national pedagogics.
"FATORES PREDITIVOS DO ACIDENTE VASCULAR CEREBRAL: UMA REVISÃO INTEGRATIVA"
Authors: Mendes Marcos Ramon Ribeiro dos Santos , Lima Neto Leonel Batista de , Carreiro Maria Amélia Gonçalves , Moura Germano Silva , Alencar Antônio Marcos de Carvalho , Pereira Deilla Patrícia Cardoso , Ribeiro Ana Selma Ferreira , Belmont Alany de Sousa Monteiro , Leal Fábia de Sá , Andrade Maria Girlândia Gregório de
Published: August 2024

Introduction: Stroke is one of the leading causes of death and disability globally, with a worrying increase of 70% in incidence, 85% in prevalence and 43% in mortality in the last three decades. This growth is especially notable in low- and middle-income countries, where mortality rates are much higher than in high-income countries. Objective: The study aims to analyze the causes and risk factors associated with stroke through an integrative review, identifying predictive factors and biological, behavioral and environmental variables that influence its incidence. Methodology: this is a literature review that analyzes the main risk factors for stroke based on articles from the last 10 years, available in English and Portuguese in the PubMed, SciELO and VHL databases.  Results and Discussion: High blood pressure is the most significant modifiable factor, as it affects all cerebral arteries and increases the risk of stroke. Dyslipidemia, with high levels of LDL cholesterol and triglycerides, contributes to atherosclerosis, increasing the risk of ischemic stroke. Diabetes mellitus causes damage to blood vessels. Smoking and the use of hormonal contraceptives are also important risk factors, as they damage arteries and promote the formation of clots. Furthermore, migraine, especially with aura, is associated with an increased risk of ischemic stroke due to vasospasms and neuronal hyperexcitability. Conclusion: This study highlighted high blood pressure, dyslipidemia and diabetes mellitus as the main risk factors for stroke. Smoking and the use of hormonal contraceptives were also highlighted as significant contributors to stroke risk. The adoption of control measures and educational actions to manage these factors is essential to reduce the incidence of stroke and its serious consequences.
IMPACTO DO PROCESSO DE EMAGRECIMENTO NA QUALIDADE DO SONO EM PRATICANTES DE ATIVIDADE FÍSICA
Authors: Alves Jéssica , Dias Kamilla , Paixão Mirian
Published: August 2024

Obesity is considered as the excessive accumulation of fat in the body, being a factor that can predispose the appearance of Obstructive Sleep Apnea Syndrome (OSAS), disturbing the quality of the individual’s sleep and disfavoring the process of recovery of the biological functions that occur in the body. sleep moment. The aim of this study was to evaluate the impact of weight loss on sleep quality in physical activity practitioners. The research is characterized as clinical, experimental, longitudinal and quantitative and qualitative. The selection of volunteers was defined by convenience, including 26 individuals, of both sexes, overweight and obese, followed for a period of 40 days and who practiced physical activity for at least 3 months. The volunteers had their nutritional status analyzed at the beginning and at the end of the intervention. The dietary prescription was carried out individually with the aim of improving eating habits and promoting a reduction of 2 to 4 kg per month. The results demonstrate that weight loss favored the reduction of WC, percentage of fat and, as a consequence, improved sleep quality after nutritional intervention. There was a reduction in symptoms related to OSAS. It is concluded that the dietary intervention with caloric restriction, together with the practice of regular physical activity, promoted a loss of body fat and an improvement in the quality of sleep, this may be one of the factors that favored the weight loss process and vice versa.
A CONTABILIDADE DIGITAL COMO FERRAMENTA DE GESTÃO APLICADA NA MICROEMPRESA X
Authors:   Ana Maria Ferreira Gomes, Abreu Alesson , da Silva Tatiana
Published: August 2024

Digital accounting is the modernization of accounting processes through information technology. It involves the use of specialized software to automate accounting tasks, such as issuing invoices, calculating taxes, and preparing financial reports. This makes it easier to access real-time information, increases data accuracy, and reduces operational time and costs. In addition, digital accounting allows for more efficient integration with other business systems, promoting a more agile and strategic financial management. Its general objective is to implement digital accounting tools in Microenterprise X, to meet this objective, we outline the following specific objectives: To analyze the existence of a digital information system in Microenterprise X in Manicoré; implement digital information systems in Microenterprise X in Manicoré and train employees to use the digital system implemented. As for the methodological procedures, the study had a qualitative-quantitative approach, through a questionnaire applied to the employees of Microenterprise X in this municipality. And as a result, we interpreted and analyzed each of the questions. Therefore, it is concluded that the implementation of digital accounting in micro-enterprises has a significant impact in several areas, promoting substantial improvements in operational efficiency, decision-making, compliance and security.
Online learning: depression, anxiety, stress symptomatology among students of Wah Medical College during covid-19 quarantine
Authors: Bibi Anwar , Farooq Sidra , Mushtaq Robina , Ahmed Aashi , Siddiqui Raima , Raza Mohsin
Published: August 2024

Introduction: The students faced new worries and issues with the discontinuation of on-
campus teaching and the change to online education during the COVID-19 quarantine.
This significant change had a detrimental effect on their mental health and cognitive
functioning.
Objectives
1. To assess depression, anxiety & stress among medical students during online learning.
2. To determine the association of depression, anxiety & stress with gender & residential
status of the students.
Material and Methods: This was a cross-sectional study, done at Wah Medical College
in Wah Cantt between December 2020 and May 2021. Data collection was done by
Google Forms, using DASS21questionnaire (Cronbach alpha >0.70). The Google form
link was shared with all 500 MBBS students through their class WhatsApp groups. Only
180 students submitted the response giving a response rate of 37%. SPSS version 26 was
used for data analysis. The descriptive variables were determined as Means & Standard
Deviation (SD), frequencies & percentages. The Chi-square test executed the inferential
analyses, with a predetermined alpha (α) < 0.05.
Results: Male students were 60(33.3 %) and 120(66.6%) were female students. The
proportion of rural students was 32 (17.8%) and 148 (82.2%) were urban students. Stress
was more reported among the students than anxiety and depression. Gender did not
significantly correlate with depression, anxiety, or stress (p-value>0.5). Depression was
significantly more reported among rural students than urban students (p-value <0.05).
Conclusion: In terms of mental health, both male and female students were equally
affected by online learning during the quarantine period of COVID-19.
Keywords: Anxiety, COVID-19, Depression, e-learning, Medical students, Online
learning, Stress.
Unveiling Alpha-Naphthoflavone Mediated CYP1A2 Suppression and Analysis of Consequent Structural Dynamics.
Authors: Piracha Zahra Zahid , Saeed Umar , Azam Naila
Published: August 2024

Background: Cytochrome P450 enzymes play vital roles in metabolizing drugs, endogenous compounds, and
environmental pollutants. Among them, Cytochrome P450 1A2 (CYP1A2) CYP1A1 and CYP1B are particularly
important for activating carcinogens. Computational modeling of CYP1A2 is essential for understanding its
interactions with various molecules, substrates, and inhibitors.
Objective: To characterize the structure of CYP1A2 and explore the binding of alpha-naphthoflavone to its active
site.
Study design: Computational modelling???
Place and duration of study: -----------------
Material and Methods: Using the Swiss PDB Viewer, we assessed the structural features of CYP1A2, focusing on
key residues, motifs, helices, and conserved regions.
Results: Our findings identified specific binding sites for alpha-naphthoflavone, highlighting its potential as a potent
inhibitor of CYP1A2. This research contributes to our knowledge of the clinical and toxicological implications
associated with CYP1A2.
Keywords: Alpha-naphthoflavone Cytochrome P450, CYP1A2, Computational modeling, Structural characterization.
Diagnostic accuracy of chest x-ray in covid -19, taking high resolution computed tomography as gold standard
Authors: Abdullah Uzma , Tariq Nafeesa , Rizwan Ayesha , Zahra Arooj , Ali Humaira , Sukh Nain , Tipu Manahil , Shoaib Amna
Published: August 2024

ABSTRACT Objective: To determine sensitivity & specificity of chest X-ray in COVID-19, taking High-Resolution Computed Tomography as gold standard. Study Design: Cross-sectional study. Place and Duration of Study: Radiology Deptt, Margalla Hospital, Taxila and Islamabad Diagnostic Centre, Wah. Two years (February 2020 to February 2022). Patients and Methods: The sample comprised 100 COVID-19 patients (Positive Polymerase chain reaction (PCR) test). Their HighResolution Computed Tomography (HRCT) was done which was considered a gold standard for diagnosing COVID-19. Their Chest X-rays (CXR) were performed, and findings of both modalities were compared. Patients having respiratory tract symptoms but PCR negative for COVID-19 were excluded. Results: The research had 49 males & 51 females having a median (IQR) age of 46.50(35-55.75) years. The minimum & maximum ages were 6 years and 83 years respectively. Among 100 PCR-positive patients, 29 were found normal on HRCT and 30 on CXR. For moderate cases, the chest X-rays were 72% sensitive & 90.67% specific, with Positive Predictive Value (PPV), Negative Predictive Value (NPV) & diagnostic efficacy of 72%,90.67% & 86% respectively. Similarly, other severity levels were assessed. Conclusion: CXR has acceptable diagnostic accuracy for COVID-19 patients, especially with good sensitivity for moderate cases and better specificity for severe cases. A portable chest radiograph might be regarded as an initial alternative imaging modality for patients with COVID-19 signs and symptoms in remote areas. Key words: COVID-19, CXR , HRCT
Effect of information and communications technology on secretarial practice in public institutions
Authors: Ahmad Sulaiman
Published: August 2024

Effect of information and communications technology on secretarial practice in public institutions
Challenges of teaching economics in Ebonyi State
Authors: Ukoro Anthonia Chukwu , Ifere Paul Ikechukwu , Chuks-Ezekwibe Ogechukwu M. , Okoche Prince Emmanuel
Published: August 2024

Challenges of teaching economics in Ebonyi State
Strategies for effective business education instruction in post pandemic period
Authors: Ubayi Anthonia U. , Hamzat Abisola Esther
Published: August 2024

Strategies for effective business education instruction in post pandemic period
Management
Authors: Arnida Yuli , Syahputra Amri  , Nanda Fitria Aulanda
Published: August 2024

The aim of this research is to determine and analyze the influence of  job training and career development on employee performance at PT Bank Sumut Imam Bonjol Branch, both partially and simultaneously. The approach taken in this research is an associative approach. This research uses primary data where data is collected using a questionnaire and uses secondary data originating from books and previous research journals. The population in this study were employees of the general division of PT Bank Sumut Imam Bonjol Branch, namely 35 people and the total sample was 35 respondents. The data collection technique uses a questionnaire. The data analysis technique in this research uses SPSS 25. The results of data analysis show that job training has no significant effect on employee performance and career development has no significant effect on employee performance. And in terms of variables, discipline, job training and career development have a significant effect on employee performance.
Blood Vessels
Authors: Akram Muhammad
Published: August 2024

Abstract:
One of the primary target tissues for inflammatory and allergy mediators is the blood vessel, and cytokines have a variety of impacts on it. We describe the usefulness of isolated blood vessels immersed in organ baths as a valuable source of pharmacological data. Contractility assays provide strong potency and selectivity data on agonists, partial agonists, and competitive or noncompetitive antagonists; however, their use in the bioassay of vasoactive drugs is gradually being replaced by more advanced analytical techniques. The human umbilical vein, for instance, has been widely utilized to identify bradykinin B2 receptor ligands. Isolated segments of vascular tissue are highly reactive living tissues, particularly in terms of regulating gene products associated with inflammation (e.g., kinin B1 receptor). The venule’s extremely thin walls have the potential to burst due to their high volume. Venules allow blood to move into larger veins. Both veins and arteries have three layers in their walls. On the other hand, venous pressure is modest. Veins are less elastic and have thin walls, allowing them to maintain a high blood circulation rate. The venous system’s high capacitance enables it to store a significant amount of blood at comparatively low pressures, containing around 75% of the circulating blood at any given time. The veins’ one-way valves permit blood to move forward toward the heart through muscle contractions.
Clinical Outcome of Anterior Cruciate Ligament Reconstruction Using Hamstring Tendon Autograft versus Tibialis Tendon Allograft Allograft
Authors: Shahpari Omid
Published: August 2024

Abstract:
Objectives: The present study aimed to examine the clinical outcome of anterior cruciate Ligament (ACL) reconstruction using hamstring tendon autograft versus tibialis tendon Allograft.
Materials/Patients and Methods: Local institutional review board approval (Code number 930971) was obtained before the commencement of the study. Thereafter, the patients who had undergone anatomical arthroscopic ACL reconstruction with hamstring tendon autograft and allograft tibialis were retrospectively reviewed. A number of 82 eligible Patients in autograft and 100 patients in the allograft group who met inclusion criteria were examined regarding knee stability by clinical examinations and KT-2000 arthrometer from 2008-2014.
Results: Anterior drawer test was reported negative in 23.18% of patients in autograft and 23% of patients in the allograft group which was not statistically meaningful (P=0.870). The mean follow-up time was reported as 36.34 and 38.34 months in autograft and allograft groups, respectively. Final score of Knee Injury and Osteoarthritis Outcome Score (KOOS) in autograft and allograft groups was measured at 70.87±19.76 and 71.83%, respectively. In addition, the mean Lysholm score in autograft And allograft groups was reported to be 90±4.77 and 3.3±92, respectively. Moreover, Mean International Knee Documentation Committee (IKDC) score in the autograft and Allograft groups was estimated as 85±14.11 and 7.03±9, respectively. Furthermore, the Mean Kujala score in autograft and allograft groups was measured at 79±3.07 and 3.75±81, respectively.
Conclusions: Apart from the mainstay treatment which is the surgical technique, the Use of quadrupled hamstring tendon autograft and tibialis allograft would yield dramatic Results in ACL reconstruction both subjectively and objectively. Moreover, the use of Hamstring tendon autograft and tibialis allograft is reported to have similar medical Results.
Mechanisms for enforcing the UN resolutions related to Israeli settlements in the occupied Palestinian territories in accordance with the rules of international law
Authors: Beshtawi Ahmed , Abu Jaafar Ahmad
Published: August 2024

This study sheds light on the attempt to find appropriate mechanisms to implement the United Nations’ resolutions related to Israeli settlements in the occupied Palestinian territories, following the rules of international law. This is prompted by Israel’s failure to comply with international resolutions, the most recent being Security Council Resolution No. 2334 issued on December 23, 2016. The study aims to highlight the concept of Israeli settlement in the West Bank and its motives, as well as to examine ways and means of prosecuting Israel, holding it responsible for the settlements before the International Criminal Court. The researchers adopted a descriptive-analytical approach for this study, which is divided into two sections. The first section focuses on the nature of the settlement crime and the legal status of the occupied Palestinian territories. The second section discusses the most important United Nations’ resolutions regarding Israeli settlement in Palestine and the mechanisms for enforcing these decisions in accordance with the rules of international law. The study concludes with a set of results, the most important of which emphasizes the necessity of using diplomatic and popular means to implement UN resolutions related to settlements in the occupied Palestinian territories.
Interpretation in Classroom Listening
Authors: Waks Leonard
Published: August 2024

Sophie Haroutunian-Gordon and the author have debated about the meaning of listening in education. For Haroutunian-Gordon, listening implies mental acts of questioning. By contrast, the author has offered a dual process account of listening, distinguishing between listening that involves explicit, consciously directed mental effort and listening that is direct and immediate and requires no effort.  The topic of “interpretation in listening” offers an opportunity for further consideration of these two types of listening. We can ask whether listeners are  always interpreting speakers’ utterances, or whether there are some acts of listening that are immediate and direct, and thus do not involve interpretation. This paper argues, based on a close analysis of the concept of listening, that many typical acts of listening in classrooms are of the second, immediate, type.
The Doings of Philosophy of Education: An Interview with Claudia Ruitenberg
Authors: Ruitenberg Claudia W. , Rocha Samuel D.
Published: August 2024

In this friendly conversation between colleagues, Claudia Ruitenberg talks with Sam Rocha about philosophy of education through the experience of being educated and doing the work of teaching, supervising, and writing philosophy of education. Biographical stories, reading habits, remarks on the reputation of the field, notes on method, and more emerge—and remain up for discussion.
Periaqueductal gray activates antipredatory neural responses in the amygdala of foraging rats
Authors: Kim Eun Joo , Kong Mi-Seon , Park Sanggeon , Cho Jeiwon , Kim Jeansok John
Published: August 2024

Pavlovian fear conditioning research suggests that the interaction between the dorsal periaqueductal gray (dPAG) and basolateral amygdala (BLA) acts as a prediction error mechanism in the formation of associative fear memories. However, their roles in responding to naturalistic predatory threats, characterized by less explicit cues and the absence of reiterative trial-and-error learning events, remain unexplored. In this study, we conducted single-unit recordings in rats during an ‘approach food-avoid predator’ task, focusing on the responsiveness of dPAG and BLA neurons to a rapidly approaching robot predator. Optogenetic stimulation of the dPAG triggered fleeing behaviors and increased BLA activity in naive rats. Notably, BLA neurons activated by dPAG stimulation displayed immediate responses to the robot, demonstrating heightened synchronous activity compared to BLA neurons that did not respond to dPAG stimulation. Additionally, the use of anterograde and retrograde tracer injections into the dPAG and BLA, respectively, coupled with c-Fos activation in response to predatory threats, indicates that the midline thalamus may play an intermediary role in innate antipredatory-defensive functioning.
Signatures of Bayesian inference emerge from energy-efficient synapses
Authors: Malkin James , O'Donnell Cian , Houghton Conor J , Aitchison Laurence
Published: August 2024

Biological synaptic transmission is unreliable, and this unreliability likely degrades neural circuit performance. While there are biophysical mechanisms that can increase reliability, for instance by increasing vesicle release probability, these mechanisms cost energy. We examined four such mechanisms along with the associated scaling of the energetic costs. We then embedded these energetic costs for reliability in artificial neural networks (ANNs) with trainable stochastic synapses, and trained these networks on standard image classification tasks. The resulting networks revealed a tradeoff between circuit performance and the energetic cost of synaptic reliability. Additionally, the optimised networks exhibited two testable predictions consistent with pre-existing experimental data. Specifically, synapses with lower variability tended to have (1) higher input firing rates and (2) lower learning rates. Surprisingly, these predictions also arise when synapse statistics are inferred through Bayesian inference. Indeed, we were able to find a formal, theoretical link between the performance-reliability cost tradeoff and Bayesian inference. This connection suggests two incompatible possibilities: evolution may have chanced upon a scheme for implementing Bayesian inference by optimising energy efficiency, or alternatively, energy-efficient synapses may display signatures of Bayesian inference without actually using Bayes to reason about uncertainty.
A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation
Authors: Amico Tommaso , Dada Samuel , Lazzari Andrea , Brezinova Michaela , Trovato Antonio , Vendruscolo Michele , Fuxreiter Monika , Maritan Amos
Published: August 2024

Many proteins have been recently shown to undergo a process of phase separation that leads to the formation of biomolecular condensates. Intriguingly, it has been observed that some of these proteins form dense droplets of sizeable dimensions already below the critical concentration, which is the concentration at which phase separation occurs. To understand this phenomenon, which is not readily compatible with classical nucleation theory, we investigated the properties of the droplet size distributions as a function of protein concentration. We found that these distributions can be described by a scale-invariant log-normal function with an average that increases progressively as the concentration approaches the critical concentration from below. The results of this scaling analysis suggest the existence of a universal behaviour independent of the sequences and structures of the proteins undergoing phase separation. While we refrain from proposing a theoretical model here, we suggest that any model of protein phase separation should predict the scaling exponents that we reported here from the fitting of experimental measurements of droplet size distributions. Furthermore, based on these observations, we show that it is possible to use the scale invariance to estimate the critical concentration for protein phase separation.
Cyclic di-GMP as an antitoxin regulates bacterial genome stability and antibiotic persistence in biofilms
Authors: Liao Hebin , Yan Xiaodan , Wang Chenyi , Huang Chun , Zhang Wei , Xiao Leyi , Jiang Jun , Bao Yongjia , Huang Tao , Zhang Hanbo , Guo Chunming , Zhang Yufeng , Pu Yingying
Published: August 2024

Biofilms are complex bacterial communities characterized by a high persister prevalence, which contributes to chronic and relapsing infections. Historically, persister formation in biofilms has been linked to constraints imposed by their dense structures. However, we observed an elevated persister frequency accompanying the stage of cell adhesion, marking the onset of biofilm development. Subsequent mechanistic studies uncovered a comparable type of toxin-antitoxin (TA) module (TA-like system) triggered by cell adhesion, which is responsible for this elevation. In this module, the toxin HipH acts as a genotoxic deoxyribonuclease, inducing DNA double strand breaks and genome instability. While the second messenger c-di-GMP functions as the antitoxin, exerting control over HipH expression and activity. The dynamic interplay between c-di-GMP and HipH levels emerges as a crucial determinant governing genome stability and persister generation within biofilms. These findings unveil a unique TA system, where small molecules act as the antitoxin, outlining a biofilm-specific molecular mechanism influencing genome stability and antibiotic persistence, with potential implications for treating biofilm infections.
Effects of strength training on repeated sprint ability in team sports players: a systematic review
Authors: Osses-Rivera Andrés , Yáñez-Sepúlveda Rodrigo , Jannas-Vela Sebastián , Vigh-Larsen Jeppe F. , Monsalves-Álvarez Matías
Published: August 2024

Objective

This systematic review was conducted to analyze the existing evidence on the effects of strength training (ST) and complex/contrast training (CCT) on repeated sprint ability (RSA) in team sports players.

Methods

A systematic review of the literature was performed following the PRISMA statement. PubMed, Web of Science, and Scopus databases were used. Original full-text articles were analyzed, without date restriction until May 26, 2024, written in English, peer-reviewed, and for eligibility must have included (1) male or female team sports players, amateur or professional category, without age restriction (2) lower extremity ST and/or CCT program (3) active control group (4) running RSA test (e.g., repeated shuttle sprint ability test or straight-line repeated sprint ability test) before and after the intervention period (5) controlled trial.

Results

A total of 3,376 studies were identified and screened. Finally, 10 articles were included based on the inclusion and exclusion criteria, all with moderate methodological quality according to the PEDro scale. The best time, mean time, and total time presented significant pre and post-test changes, using ST in 3, 2, and 1 experimental groups, respectively, and using CCT in 1, 1, and 1 experimental groups, respectively, with almost no differences in the percentage decrement most commonly reported in RSA tests. There were no changes in the control groups.

Conclusion

Together, ST performed in a range of maximal power provides benefits in the best time and mean time and performed between 80 to 95% of 1 repetition maximum (RM) provides benefits in the best time, mean time, and total time in RSA tests. CCT performed between 75 to 90% of 1 RM combined with jumps and sprints provides benefits in the best time, mean time, and total time in RSA test, but no unaltered percentage decrement in ST and CCT in elite and semi-professional team sport players.