bluuebunny/crossref_metadata_2025 huggingface dataset:
Computerized Device for Monitoring ECG and PPG Signals - Design and Redesign Based on Value Engineering Method
Authors: Vîlcu Adrian , Luncă Eduard , Vornicu Silviu , Herghiligiu Ionuţ-Viorel , Toporăscu Claudia
Published: November 2023

In the current medical, social, and technological context, where cardiovascular diseases have a high incidence in mortality statistics, dynamic social life, and rapid technological advancements, computerized systems for monitoring personal health parameters, independent of the medical system, are in great demand. The current research aims to design a prototype of a computerized system for monitoring cardiac activity (ECG and PPG) and improve it through functional optimization using an incremental innovation method based on value engineering applied to the product. This paper presents the stages of physical prototyping, device design based on its primary functions, functional optimization through balancing the cost-effectiveness ratio for each function, selecting device redesign solutions, and implementing them in the final product. The novelty of this research lies in the physical realization of a cardiac activity monitoring prototype and the application of an incremental innovation methodology and device redesign. The research falls within the technical field -through the development of the ECG-PPG prototype - and the economic field -through the application of functional analysis to improve this device.
Complex Dose Rate Calculations in Luminescence Dating of Lacustrine and Palustrine Sediments from Niederweningen, Northern Switzerland
Authors: Preusser Frank , Degering Detlev , Fülling Alexander , Miocic Johannes
Published: November 2023

This study focusses on dose rate determination in complex settings in two drill cores from the site of Niederweningen, northern Switzerland. A crosscheck with a certified standard material and neutron activation analyses (NAA) reveals an overall good performance of high-resolution gamma spectrometry (HR-GS) when determining dose rate-relevant elements. A second focus is on average water content during burial, by comparing measured sediment moisture with water uptake capability. Furthermore, layer models are used to investigate the impact of inhomogeneous stratification on dose rate. Finally, different scenarios to correct for radioactive disequilibrium in the uranium decay chain are investigated. While most of the applied corrections appear to have only a minor to moderate effect on age calculation, the results for one core are contradictory. Possibly, some of the applied correction scenarios are not reflecting the complex natural setting sufficiently, in particular average sediment moisture during burial and the timing of radioactive disequilibrium might be incorrectly estimated. While deposition in one core can be quite securely attributed to the period 100–70 ka, assigning the sediment sequence in the other core to the time between ca. 130 ka and 90 ka remains to some extent insecure.
Determination of Radiocarbon Content in Bio-Oil Samples by Mini Carbon Dating System in the Gliwice Radiocarbon and Mass Spectrometry Laboratory
Authors: Baranyika Jean Baptiste , Piotrowska Natalia
Published: November 2023

The applications of isotopes are used by many European countries to investigate environmental changes. A compact modern accelerator mass spectrometry (AMS) system known as Mini Carbon Dating System (MICADAS) is used in Gliwice Radiocarbon and Mass Spectrometry Laboratory for determining the 14C content in different environmental samples including liquid fuels. For radiocarbon measurement using MICADAS, the liquid samples are accurately prepared using the tin capsules for liquids for combustion in elemental analyser (EA) and graphitisation in the AGE system. In this study, the determination of 14C content in three different bio-oil samples and one reference sample of 100% biomass was conducted. Bio-oil samples were prepared using tin capsules for liquids sealed in the second capsules for solids to avoid sample evaporation while the reference sample was prepared using the tin capsule for solids for combustion in EA and graphitisation in the AGE system. Based on the 14C measurement results, one of the bio-oils was not produced from the analysed reference biomass. Two others were determined as a mixture of bio- and fossil components, and based on 14C the bio-carbon content was calculated. For all samples, the 14C measurement showed reproducible and reliable results.
Rethinking of the Vernacular Adobe Architecture Rehabilitation
Authors: Nemcsics Ákos , Ürmös Antal , Gröller György
Published: November 2023

In recent work, heat-technical modeling, life cycle assessment, and rehabilitation of the vernacular adobe wall house is discussed. Our topic choice is based on the fact that a significant part of the Hungarian rural housing stock consist of adobe-walled buildings. The adobe wall construction is especially perfect for the seasonal climatic equalizing, which property has increasing ecological importance due to the effect of growing global warming up. Largely, these adobe-walled houses are part of our cultural heritage, therefore they are worth to preserving. Finally, their constructional conservation, energetical rehabilitation and also maintenance problems are briefly described..
Artificial Intelligence and Architecture Towards a New Paradigm
Authors: Lukovich Tamas
Published: November 2023

The widespread application of artificial intelligence is not the realm of utopias or science fiction any more. It is gradually entering practically all walks of life from science and technology to fine arts. It is most likely that architecture will neither escape this penetration in the near future. Moreover, besides some disturbing consequences, it will also reveal fundamentally new opportunities for the discipline/profession. It is up to us to decide what attitude we adopt towards it, but it is clear that this development should have profound consequences in the education of future architects, too. The paper focuses on the creative core (i.e. design) of architecture. The aims are to assess the changes and to raise awareness to these possible changes.
Proposals on open design competition to revitalize collage building in Javor street
Authors: Mizsei Anett
Published: November 2023

University of Obuda Ybl Miklós Faculty of Architecture and Civil Engineering launched an architectural competition to seek for forward-looking solutions for rehabilitation and revitalization of an unused and eroding building. The estate in question is located near the Faculty campus, under 9. Javor Street, 1145, Budapest. When the possibility of a renovation arose, leaders of the Faculty decided to involve the community of the students in order to represent their points of view. The open, secret competition had been launched on 8th September, and by the deadline 30th November fifteen proposals were submitted. Two of the most promising designs were awarded 1st prizes, one got a 2nd prize and two further submissions earned 3rd prize..
Investigation of Noise Immunity Telecommunication Systems According to the Criterion Energy Efficiency
Authors: Ibrahimov Bayram
Published: November 2023

Methods for improving the characteristics of the reliability message transmission in multiservice telecommunication networks in the provision of multimedia services are analyzed. The noise immunity reception, effective methods modulation, paths transmission systems, indicators of information, frequency and energy efficiency of the system, methods of processing and receiving messages are considered. The problems of optimizing signal-code constructions according to the criterion of energy efficiency of a telecommunications system are studied. A new approach to the construction of methods for calculating the indicators of noise immunity of receiving messages is proposed, taking into account signal-code structures. The developed calculation method takes into account effective types of modulation, demodulator synthesis algorithms, signal processing methods, bandwidth, signal-to-noise ratio and energy efficiency indicators. On the basis of the calculation method, important analytical expressions were obtained that evaluate the characteristics of the noise immunity reception, taking into account the indicators energy efficiency, throughput per sample, the conditions for the indicators of the signal-to-noise ratio and the probability erroneous reception discrete signals.
Optimization of Broadband Microstrip Antenna Device for 5G Wireless Communication Systems
Authors: Islamov Islam
Published: November 2023

The paper proposes a new method for finding the optimal design of complementary split ring resonator cells for a microstrip antenna, which makes it possible to purposefully optimize the parameters of resonator cells, which significantly improve the electrical characteristics of the antenna. This antenna is designed for cellular communication 5G. The proposed method combines a regression model using a deep network based on fully connected neural layers with a search based on the conditional optimization algorithm COBYLA to find the optimal design parameters of resonator cells. This approach fully automates the process of creating microstrip antennas with resonator cells based on metamaterials and makes it possible to find the parameters of complementary split ring resonator cells that provide the optimal operating mode as a whole and gives the maximum level of antenna radiation while maintaining the bandwidth. The small size of complementary split ring resonator cells opens up the possibility of using this peculiar configuration to create compact and efficient microstrip antennas.
Graph-Based Approach for Personalized Travel Recommendations
Authors: Turno Francesco Maria , Jackiva Irina Yatskiv
Published: November 2023

In the evolving domain of urban mobility systems, the integration of technology with user-centric strategies is pivotal. This research stands on the foundational concept of Mobility-as-a-Service, a user-centric intelligent mobility management distribution system that seeks to prioritize human needs over mere technological infrastructure. The study delves deep into the wealth of data available through mobile sensing technologies, highlighting the unprecedented understanding it offers into human mobility patterns, thus facilitating personalized route recommendations.

The literature categorizes the study area into three interlinked categories: point-of-interest (POI) recommendation, travel planning, and trajectory modelling. In a significant stride, this research introduces a comprehensive understanding of hu-man mobility data and proposes a novel framework designed to tender personalized recommendations to travel planner users. The innovative framework employs a graph-based approach rooted in the Sussex-Huawei Locomotion dataset, leveraging an adaptation of Bellman-Ford’s algorithm. This modification considers factors such as perceived fatigue, frequency of trips to specific locations, and proximity to POIs, promising a path routed in past user experiences and preferences.
The impact of website design on consumer decision making – evidence from North Macedonia
Authors: Blagoeva Kalina Trenevska , Mijoska Marina , Pulevska-Ivanovska Lidija
Published: November 2023

Today, almost one third of the world population are digital buyers. The hypothesis that more life moves online, the less damage to our environment is still unclear. E-commerce sites and the underlying supply chain can have both positive and negative impacts on the environment. Sustainable web design is an approach to designing websites that puts people and the planet first. It is a growing movement as organizations look for opportunities to reduce their influence on the environment. This research elaborates on determinants of consumer behavior that shape online purchase processes and affect the final consumer decision to buy. It discusses the importance of website design on consumer decision-making in e-commerce. Consumer decision-making and behavior during online shopping in the literature are measured by numerous models. One of the primary motivators for any online store to attract customers is the quality of website design. Website quality refers to the overall excellence, effectiveness, and usability of a website. It influences consumers’ perceptions of product quality and affects online purchase intentions (Sun, Chen, and Huang, 2014) and even continuation intentions (Chawla et al., 2015). Website quality as well positively affects online impulse buying behaviour (Akram et.al. 2018). The design of a website interface plays an important role in online purchasing, and customers are more likely to visit and buy from better-designed websites (Chiu and Yang, 2016). This paper proposes that website design quality is a multi-dimensional construct. To support the importance of the construct, a review of different studies is conducted elaborating on the impact of website design on consumer attitude and behavioral intention in North Macedonia. This study has theoretical and practical implications on the existing knowledge and provides managerial insights for e-vendors implying that to promote online shopping, they need to improve the quality features of the website and enhance users’ trust.
presupuestos morales en el estado de naturaleza hobbesiano
Authors: Jiménez Morales Luis Alberto
Published: November 2023

El objetivo de este artículo es realizar una revisión del estado de la cuestión sobre el concepto de estado de naturaleza en el pensamiento de Thomas Hobbes. Dicha revisión permite articular una comprensión de la naturaleza humana, puesto que a diferencia del realismo político el estado de naturaleza en Hobbes no tiene un rol meramente hipotético. Precisamente, la idea de naturaleza humana articula una proto-moralidad que permite comprender la transición hacia el estado civil. Las investigaciones Kavka, Gauthier y Hampton han construido una compleja compresión de la naturaleza humana, la cual permite entender cierto sustrato de proto-moralidad en el pensamiento hobbesiano.
Características da assistência à saúde bucal de gestantes em um estado do Nordeste do brasileiro
Authors: Pessoa Inês Barros , Silva Amanda Almeida da , Gomes Alan Araújo , Raposo Rebeca Carvalho , Duarte Karlinne Maria Martins , Monier Elza Bernardes , Neves Pierre Adriano Moreno , Pinho Judith Rafaelle Oliveira
Published: November 2023

Objetivo: Analisar a organização do serviço de assistência à saúde bucal da gestante no estado do Maranhão. Métodos: Foi realizado um estudo exploratório. Os dados foram coletados através de um formulário eletrônico para obter informações das coordenações municipais de saúde bucal do Maranhão, no período de maio a julho de 2022, totalizando 100 municípios. As informações foram digitadas no software Microsoft Excel® e exportados para o Stata® 12.0 e permitiram o mapeamento do cenário da assistência à saúde bucal no Estado. Resultados: Os municípios analisados representam 1138 equipes de saúde bucal (65,78%), destas 1059 (61,21%) foram apontadas pelo gestor respondente que fazem o acompanhamento do pré-natal odontológico. Com relação à assistência à saúde bucal somente 32% (n=32) afirmaram que há determinações de protocolos clínicos para o atendimento odontológico à gestante na APS, 28% (n=28) dos municípios relataram que não possuem qualquer registro desse fluxo e que 46% (n=46) o fazem através de documento físico. Conclusão: Observou-se que não existem protocolos clínicos padronizados para o atendimento odontológico às gestantes, fazendo com que os profissionais atuem sem direcionamentos para condutas clínicas.
Some technical options for successful PulseRider procedures
Authors: Kanazawa Ryuzaburo , Uchida Takanori , Higashida Tetsuhiro , Watanabe Saiko , Kono Takao
Published: November 2023

Background:

Unlike other conventional neck bridge stents, when using the PulseRider (PR), it is not necessary to introduce a microcatheter for stent delivery into the daughter branches from the neck, and it has less intraluminal metal. However, in some cases, securely introducing both leaflets into daughter vessels may be difficult, leading to coil herniation. This study aimed to present some technical issues in PR deployment.

Methods:

Fourteen PR procedures were performed in our institution between August 2021 and June 2023, and T-type PRs were used in all procedures. Four technical points during PR procedures are presented from our experience, as “technical options (Options 1-4)”. All procedures were carried out with T-type PR implants.

Results:

The PR was successfully placed in all interventions; however, in seven cases (50%), some technique trials were necessary because the leaflets did not unfold in the optimal directions. In Option 1, an introduction procedure with transposition of the daughter artery using a microcatheter is presented. In Option 2, the method for correction of the unfolded leaflet angle is demonstrated. In Option 3, another method for correction of the leaflets is shown. In Option 4, an effective method for neck protection during PR procedures is shown.

Conclusion:

Various options should be considered to achieve appropriate apposition of PR leaflets. These technical options may be safe and effective for successful PR deployment.
Major Challenges of Cognition and Legal Content of Property and Contract in Hegel’s Philosophy of Law
Authors: Шаульский В.С. , Вождаев М.М.
Published: November 2023

В настоящей статье исследованы основные вопросы методологии Гегеля в контексте ключевых понятий теории гражданского права – понятий «собственность» и «договор». Общеевропейское значение имеет «Философия права» – одна из главных работ Гегеля, посвященных рассматриваемым вопросам, что является важным фактором при обращении к ней современных ученых-юристов. Авторы полагают, что содержательный потенциал предложенной Гегелем систематики юридических понятий далеко не исчерпан, и он требует внимательного изучения в целях совершенствования методологии общей теории права.

The article examines major issues of Hegel's methodology in the context of key notions of the theory of civil law: the notions of property and contract. One of Hegel’s key studies addressing the issues at hand, the Philosophy of Right, is of the all-European significance which is an important factor for modern legal scholars to refer to. The authors believe that the meaningful potential of systematics of legal concepts proposed by Hegel is far from being exhausted and that it requires careful study in order to improve the methodology of the general theory of law.
Activities of Central Bank as Megaregulator of Financial Market in Prevention of Criminal Income Legalization
Authors: Гладкова С.Б.
Published: November 2023

Проанализирована деятельность Центрального банка Российской Федерации как мегарегулятора на российском финансовом рынке в контексте наделения его надзорной и контрольной функцией в области противодействия легализации доходов, полученных преступным путем, преступных доходов и финансирования терроризма (далее – ПОД/ФТ). Обозначены конкретные меры регулятора (Банк России) по борьбе с отмыванием преступных доходов, а также определены преимущества и недостатки организационной модели, при которой надзор с целью ПОД/ФТ осуществляется органом банковского надзора.

The activities of the Central Bank of the Russian Federation as a mega-regulator in the Russian financial market are analyzed in the context of its supervisory and control functions in the field of combating the legalization of criminal income and terrorist financing. Specific measures of the regulator (the Bank of Russia) to combat money laundering are outlined, we describe the advantages and disadvantages of the organizational model stipulating the supervision role of the bank.
Influence of Functional Strategy of Innovative Changes on Achieving Region’s Intended Economic and Social Results
Authors: Кроливецкая В.Э.
Published: November 2023

В статье рассматривается влияние функциональной стратегии инновационных изменений на достижение в системе стратегического планирования социально-экономического развития региона поставленных социальных и экономических результатов в перспективном периоде времени. Раскрывается роль функциональных стратегий инновационных изменений в поддержании устойчивых тенденций роста объёмов внутренних текущих затрат на научные исследования и разработки, производства инновационной продукции, выполнения работ, оказания услуг в региональном хозяйстве.

We examine the impact of the functional strategy of innovative changes on achieving social and economic results in the long-term period in the system of strategic planning of regional social-economic development. We specify the role of functional strategies of innovative changes in maintaining the growth of internal current research and development costs, the innovative products manufacturing, work performance and services provision in the regional economy.
Assessment of State and Key Directions of Development of Passenger Road Transportation in Leningrad Region
Authors: Селиванова Л.А. , Васильева Н.В. , Соколов В.В.
Published: November 2023

В статье приводится краткий анализ состояния отрасли пассажирских автоперевозок в Ленинградской области. Выявлена вся совокупность факторов, негативно воздействующих на инфраструктуру отрасли. Определены основные направления развития отрасли на перспективу.

We briefly analyze the current state of passenger road transportation in Leningrad region. All the factors negatively affecting the infrastructure of the industry in question are revealed. The key directions for the long-term industry development are determined.
Theoretical Aspects of Standardisation Impact on Growth and Development
Authors: Гагулина Н.Л.
Published: November 2023

В статье проанализирована институциональная роль стандартизации и рассмотрена ее нормативно-правовая база и стандарты, сконцентрированные на улучшении качества жизни в экономике знаний. Концептуальной базой проведенного исследования являются основы экономики качества. Автор рассматривает стандартизацию как фактор роста и развития. На примере стандарта ГОСТ Р ИСО 37120-2020 «Устойчивое развитие сообщества. Показатели городских услуг и качества жизни» показана институциональная роль стандартизации в обеспечении устойчивого развития и высокого качества жизни.

We analyze the institutional role of standardization and consider its legal foundations and standards focused on improving the quality of life in knowledge economy. Conceptually the research is based on the quality economics. The standardization is seen as a factor of growth and development. Using the example of GOST R ISO 37120:2020 standard we showthe institutional role of standardization in ensuring sustainable development and high quality of life.
Implementation of Green Logistics and Transport Programs: Analysis of European Experience
Authors: Корчагин А.А. , Корчагина Е.В.
Published: November 2023

В статье представлен анализ программ в сфере зеленой логистики и транспорта, успешно реализованных ранее и реализуемых в настоящее время в странах ЕС. Основной фокус внимания авторов был сделан на целях и задачах данных программ, их достоинствах и недостатках, а также особенностях финансирования. Результаты анализа позволяют сделать вывод о перспективности разработки и реализации аналогичных программ в сфере транспортно-логистической инфраструктуры, интеграции транспортного комплекса и использования экологичного топлива на пространстве ЕАЭС.

We analyze the green logistics and transport programs having been implemented and currently being implemented in the European Union. We focus on the aims and tasks of the programs in question, as well as their advantages and disadvantages and features of funding. On the basis of the analysis we make a conclusion about the prospects of developing and implementing similar programs connected with the transport-logistics infrastructure, the integration of transport complex and the use of environmentally friendly fuel in the Eurasian Economic Union.
Artificial Intelligence Error as Force Majeure
Authors: Новицкий В.А. , Паршонков В.В.
Published: November 2023

Анализируется проблема квалификации ошибок искусственного интеллекта в качестве обстоятельства непреодолимой силы (форс-мажора). Авторами проведено комплексное исследование доктринальных положений о регулировании ответственности искусственного интеллекта. Результаты исследования свидетельствуют о наличии множества подходов, которые регулируют ответственность искусственного интеллекта по-разному. Сформулированы случаи, в которых ошибка искусственного интеллекта может быть квалифицирована в качестве обстоятельства непреодолимой силы (форс-мажора).

We analyze the problem of qualifying artificial intelligence errors as force majeure. We carry out a comprehensive study of the doctrinal provisions concerning the regulation of artificial intelligence liability. As a result, we have discovered a variety of approaches that regulate the responsibility of artificial intelligence in different ways. We specify certain cases when an artificial intelligence error can be qualified as force majeure.
The Algorithm of Actions Aimed at Restoring Lost Title Documents for Residential Real Estate Resulted from Special Military Operation in DPR, the City of Mariupol
Authors: Резниченко В.А.
Published: November 2023

В статье рассмотрено действующее законодательство Российской Федерации, раскрыты проблемные вопросы, связанные с реализацией права на недвижимое имущество, а также приведен алгоритм действий для граждан по восстановлению утраченных правоустанавливающих документов на жилую недвижимость. Актуальность исследования обусловлена тем, что при проведении специальной военной операции по демилитаризации и денацификации на Украине, в процессе применения действующего законодательства РФ, возник ряд сложных юридических задач, связанных с осуществлением прав граждан на владение, пользование и распоряжение своим имуществом при утрате правоустанавливающих документов. Утверждается, что право на владение и распоряжение своим имуществом является важным социальным фактором для граждан.

The article examines the current legislation and problematic issues related to the realization of the right to immovable property, and also provides an algorithm of actions for citizens to restore lost title documents for residential real estate. The relevance of the topic is due to the fact that in the process of applying the current legislation of the Russian Federation during the special military demilitarization and denazification operation in Ukraine a number of complex legal challenges have occurred with regard to exercising citizens' rights to own, use and dispose of their property in case of title documents loss. It is alleged that the right to own and dispose of one's property is an important social factor for citizens.
ON DETECTIVE COUNTERACTION TO ILLICIT TURNOVER OF SPECIAL TECHNICAL EQUIPMENT INTENDED FOR SURREPTITIOUS OBTAINING OF INFORMATION
Authors: Ахмедов А.Г. , Пчоловский Н.К.
Published: November 2023

В статье сформулировано понятие правовой основы применения специальных технических средств, предназначенных для негласного получения информации и используемых в качестве орудий совершения преступлений. Приведен их перечень, а также указано, что противоправное применение специальных технических средств позволяет преступнику осуществлять бесконтрольное получение информации для подготовки и совершения преступлений, фиксировать полученную информацию, скрывать следы преступной деятельности.

The article formulates the concept of legal basis for implementation of special technical devices for surreptitious obtaining of information and provides the list thereof used as instruments of crime. It is noted that the illegal use of special technical equipment allows the criminal to receive information uncontrolled for the preparation and commission of crimes, to record information and to cover criminal activity.
Specific Features of Investigative Activities Aimed at Obtaining Statements from Participants in Criminal Proceedings
Authors: Рамазанов Р.А.
Published: November 2023

В статье рассмотрены особенности производства следственных действий, направленных на получение и проверку показаний на стадии предварительного расследования. Охарактеризованы особенности и порядок проведения допроса, очной ставки, проверки показаний на месте. Определены подходы в правоприменительной практике, связанные с проведением следственных действий, исключающих нарушение процессуального порядка, с целью признания полученных доказательств допустимыми.

The article focuses on specific features of investigative activities aimed at obtaining and verification of evidence at the pre-trial investigation. Particular attention is made to describing features and procedures related to interrogation, confrontation and on-site verification. Relevant approaches are defined with regard to law enforcement practices dealing with investigative activities aimed at excluding violation of procedural order to make the evidence admissible.
OLIVES: A Go-like Model for Stabilizing Protein Structure via Hydrogen Bonding Native Contacts in the Martini 3 Coarse-Grained Force Field
Authors: Pedersen Kasper B. , Borges-Araújo Luís , Stange Amanda D. , Souza Paulo C. T. , Marrink Siewert-Jan , Schiøtt Birgit
Published: November 2023

Coarse-grained molecular dynamics simulations enable the modeling of increasingly complex systems at millisecond timescales. The transferable coarse-grained force field Martini 3 has shown great promise in modeling a wide range of biochemical processes, yet folded proteins in Martini 3 are not stable without the application of external bias potentials like elastic networks or Go-like models. We herein develop an algorithm, called OLIVES, which identifies native contacts with hydrogen bond capabilities in coarse-grained proteins and use it to implement a novel Go-like model for Martini 3. We show that the protein structure instability originates, in part, from the lack of hydrogen bond energy in the coarse-grained force field representation. By using realistic hydrogen bond energies obtained from literature ab initio calculations, it is demonstrated that protein stability can be recovered by the reintroduction of a coarse-grained hydrogen bond network and that OLIVES removes the need for secondary structure restraints. OLIVES is validated against known protein complexes, and at the same time addresses the open question of whether there is a need for protein quaternary structure bias in Martini 3 simulations. It is shown that OLIVES can reduce the number of bias terms, hereby speeding up Martini 3 simulations of proteins by up to ≈ 30 % on GPU architecture compared to the established GoMARTINI Go-like model.
Carbon Quaternization of Redox Active Esters and Olefins via Decarboxylative Coupling
Authors: Gan Xu-cheng , Zhang Benxiang , Dao Nathan , Bi Cheng , Pokle Maithili , Collins Michael , Tyrol Chet , Bolduc Philippe , Nicastri Michael , Kawamata Yu , Baran Phil , Shenvi Ryan
Published: November 2023

The synthesis of quaternary carbons often requires numerous steps and complex conditions or harsh reagents that act on heavily engineered substrates. This is largely a consequence of relying exclusively on conventional polar-bond based retrosynthetic disconnections that in turn require multiple functional group interconversions, redox manipulations, and protecting group chemistry. In fact, the presence of a quaternary center even in seemingly trivial structures can dominate the practitioner's entire retrosynthetic plan (referred to by Corey as a “keying element”). Here we report a simple catalyst and minimal reagents that convert two types of feedstock chemicals—carboxylic acids and olefins—into tetrasubstituted carbons via quaternization of radical intermediates. An iron porphyrin catalyst activates each substrate by electron transfer or hydrogen atom transfer then combines the fragments by an SH2 reaction. This cross-coupling reduces the synthetic burden to procure numerous quaternary carbon-containing materials from simple chemical feedstocks.
A Chemistry in Water Reproducibility Study: Learnings from a Pre-Competitive, Multi-Company Collaboration
Authors: Fox Richard , Bailey Daniel , Obligacion Jennifer , Borlinghaus Niginia , Braje Wilfried , Li Xiaoyong , Mukherjee Subha , Schoen Adeline , Towne Timothy , Vukelic Stella
Published: November 2023

Despite the reported successes and advantages involving the use of amphiphilic surfactants, most notably TPGS-750-M, to enable a multitude of synthetic transformations to be conducted in water, implementation of this methodology within the pharmaceutical industry has been relatively limited. In this paper, we will disclose the key results and learnings from a multi-company collaboration focused on a reproducibility study involving some of the most commonly used reaction types in the pharmaceutical industry, specifically amidation, SNAr, nitro reduction, reductive amination and multiple Pd-catalyzed transformations in water. Key to this study will be the presentation of results not just from the originally reported TPGS-750-M conditions, but also under the water-only control and with three different surfactants, as well as on both small (i.e., <500 mg) and mid (~10 g) scales.
SHARP pack: A modular software for incorporating nuclear quantum effects into non-adiabatic quantum dynamic simulations in condensed phases
Authors: K. Limbu Dil , A. Shakib Farnaz
Published: November 2023

SHARP pack, short for Surface Hopping And Ring Polymer package, is a highly-parallelized software with a modular structure developed to help widespread usage of approximate non-adiabatic dynamics methods which incorporate nuclear quantum effects into the condensed-phase molecular dynamics simulations. The latter is achieved through the extended phase space of a classical ring polymer, according to the Feynman’s imaginarytime path integral formalism, as implemented in the Ring Polymer Surface Hopping (RPSH) methodology. While SHARP pack comes with a spectrum of models and reaction conditions, the modular architecture allows the implementation of new models, methods, and reaction conditions for developing wider classes of approximate non-adiabatic dynamics methodologies.
Excess Savings and Consumer Behavior: Excess Compared to What?
Authors: DeLuca Martin J. , Pinheiro Roberto B.
Published: November 2023

How much accumulated savings do households hold, and what do these savings imply about future consumption? Economists typically consider excess savings when gauging the level of savings that households may use to maintain real consumption as costs rise. Economists have estimated strikingly different levels of currently held excess savings. We highlight the differences between measures of counterfactual savings—that is, the amount of savings households would be expected to hold barring unusual events—and their relevance in computing post pandemic excess savings. Furthermore, we show that, using counterfactual savings that rely on the idea of consumption smoothing, excess savings are currently positive in the case that households assume that recent income losses are transitory. These findings carry additional implications for expected personal consumption expenditure patterns.
ADVISABILITY IN THE GLOBAL STRUCTURE OF BEING AND THE FUTURE OF HUMANITY
Authors: Shapoval Volodymyr
Published: November 2023

The article attempts to show a new perspective on the problems of advisability of human activity and processes occurring in being in general, to determine their rational and irrational components, as well as to reveal their deep meaning. The author stands for the idea that the progressive development of advisability processes is in the direction of acquiring an increasingly greater degree of complexity.

Human civilization can be considered as a logical link of this process. Nowadays the stage of civilization development shows that it is at a crossroads, facing the alternatives of the transition to a new level of complexity. The first one lies in following the path of consistent introduction of new technologies and creation of artificial intelligence with unlimited possibilities that will probably become a successor of the human stage of evolution. The second one is to find the ways of human enhancement as a biological being with the help of genetic engineering. Such human being will have extraordinary physical and intellectual qualities that will be by far superior to the qualities of modern people.

In any case, the transition to a new level of complexity is an urgent need. However, whether this transition will be made expediently and reasonably, or chaos will increase which will lead to collapse and to a more stable level of simplicity, this is the question to which there is no answer yet.
SCIENTIFIC WAYS OF MASTERING UNCERTAINTY IN A TURBULENT SOCIETY
Authors: Kubalskyi Oleh
Published: November 2023

Modern society is characterized by permanent challenges that create a situation of the need to preserve the key parameters of social development, taking into account temporary and situational deviations from the strategic direction of this development. The key to understanding the problem of determination in modern science can be the identification of regularities in the development of science itself. On the one hand, there is no doubt about the need to systematize knowledge and adhere to clear scientific criteria – especially in a situation of exponential growth in the volume and variety of knowledge possessed by modern society. On the other hand, science constantly abandons some part of its recent postulates, which turn out to be only partially proven hypotheses that have only partial truth. In the end, only the basic scientific criteria and the instruction for incessant internal criticism and self-improvement of science remain beyond doubts and changes, while the substantive part of science is in a state of permanent transformation and refinement. In a postmodern society, such a methodological and worldview instruction of science receives additional ideological legitimation thanks to postmodern principles of knowledge organization – such as rhizomaticity, discursiveness, narrativism, intertextuality, etc. The signs of science at its current stage of development are: a significant increase in the specific weight of interdisciplinary and interdisciplinary research; emergence of new integrated sciences; the use of accurate methods in the study of methodological and epistemological problems of science and the demarcation of knowledge; search for new forms of research adequate to the latest specificity of the subject of the socio-humanitarian disciplinary spectrum; an intensive analysis of the relationships between the epistemological and axiological foundations of socio-humanitarian science. The research approach, which is based on the understanding of the factor of instability, fully meets the modern scientific and social demand for the designation of the content format and problematic challenges of modernity, provides an opportunity to grasp new cognitive horizons and slices of reality, which are characterized by signs of becoming, nonlinearity, uncertainty – that is, almost all attributes of a turbulent society.
Hyper chaos followed by DCT and gyrator transform for image encryption
Authors: Thamizhmaran K.
Published: November 2023

Color images can be encrypted using a hyperchaotic system in the Discrete Cosine Transform (DCT) and gyrator transform domains. These encryption techniques provide an added layer of security to protect sensitive image data from unauthorized access or tampering. The Red, Green, And Blue (RGB) components of the original color image are encoded into two-dimensional streams, respectively. These two-dimensional streams, representing the RGB components, are then processed by the display or printing device to recreate the full-color image. This paper proposes a new image encryption scheme that integrates DCT and the gyrator transform simultaneously. This innovative approach enhances the security and robustness of image encryption, making it suitable for a wide range of applications in data protection and transmission. Specifically, four chaotic sequences generated by a hyperchaotic system are blended into streams to synthesize complex sequences. Subsequently, the two-dimensional complex streams are scrambled using the discrete cosine transform and encoded back into an image format. Finally, the parameters in the hyperchaotic system using DCT and the gyrator transform improve the security of the proposed scheme. Theoretical and experimental analyses both confirm the security and validity of the proposed work.
Mitologizacja dzieciństwa – "Wysoki Zamek" i "Sklepy cynamonowe"
Authors: Skiba Tymoteusz
Published: November 2023

At the core of Bruno Schulz’s and Stanisław Lem’s imaginary are the same images of magical phenomena and rituals formed in their childhood. These prospections of two children, these two overpast worlds, almost thirty years apart, separated by groundbreaking political events, are surprisingly close to each other. Schulz devoted his writing to a constant interpretation of these primal ideas and “pre-set verses”. Lem deposited this potential in one book, Highcastle: A Remembrance. Lem’s autobiography is connected with Cinnamon Shops not only by the same repertoire of motifs and memories, but also by a characteristic style and metaphorization of language. The Highcastle turns out to be a record of the Lem’s mythology of his Lviv childhood – just like the Cinnamon Shops, the book that mythologizes Schulz’s childhood in Drogobych. The paper is an attempt to analyze these two mythologies, and indicate points of contact as well as references and polemics in Lem’s text.
Kometa i rakieta: postęp technologiczny w intertekstualnych konstelacjach "Komety" Brunona Schulza i "Tęczy Grawitacji" Thomasa Pynchona
Authors: Arich-Gerz Bruno
Published: November 2023

Twentieth-century literary representations of objects that fall from the sky include technological, man-made items as well as natural phenomena. Writers have contributed their specific readings to instances of this kind, and have grafted specific symbolic meanings on these phenomena. The falling object in question can be a supersonic rocket like the one that constitutes the thematic center of the American novelist Thomas Pynchon’s 1973 Gravity’s Rainbow. It may likewise be a celestial body, a larger and usually more destructive one than a mere meteor — a bolide, in other words, like the one Bruno Schulz describes in his 1938 story “Kometa”. What the rocket and the comet have in common is that Pynchon and Schulz ascribe a special significance to their respective flight curves and, more specifically, to the turning point of this parabola. Pynchon associates the issue of immobility at the rocket’s turning point with that of transformation; an instance mirrored in the text by Schulz, who moreover does so – again like Pynchon later – with reference to cyclists transmogrified into frozen firmament riders. The paper identifies a common intertextual reference point for this in the poetry of Rainer Maria Rilke. It demonstrates the impact as well as the similarities, but also interpretational differences of the Rilkean constellation of new stars named “Rider” in Schulz’s and Pynchon’s fiction.
Mit tricksterski i jego ślady u Schulza
Authors: Tarnowska Balbina
Published: November 2023

Paul Radin in his classic book dedicated to the trickster in Native American cultures pointed out that this mythical figure appears in cultures all over the world. This “jester’s ancestor,” as Monika Sznajderman named him in her monograph Jester. Masks and Metaphors, is called conjurer, “divine rascal”, and cheater. The trickster is known in various mythologies, so he might be present also in the private mythology of Schulz. The first part of the article is an attempt to compare the father from Schulz’s stories with the trickster. My purpose is not to insist that Jakub = trickster, but to show some similarities between these two figures. In the second part, I describe two analogous scenes of selfcastration (from the Winnebago Trickster Cycle and from the letter of Bruno Schulz to Stefan Szuman). Using Lewis Hyde’s book Trickster Makes This World: How Disruptive Imagination Creates Culture, in which he included interpretations of the works of some modern artists in the context of the trickster myth, I make an effort to look at Schulz as an artist-trickster. The metaphor of trickster refers to those artists who know that the “creative spirit” must abandon concepts that are “exact and predictable.” Schulz implements that model in his critique of European culture, but not only at that point. If we look at the reception of his work in the interwar period, we can see that he was perceived as inconvenient for those who accused him of not fulfilling the postulates that the critic of the 1930s expected. There were objections to his work as apolitical, amoral, propagating anti-humanism, perpetuating chaos and the lack of hierarchy, socially useless. “If art was only to confirm what already had been saved, it would be unnecessary,” he wrote. In that idea of art which is naturally amoral, “a probe sunk into the nameless”, looms the impenetrable face of the trickster, the jester who is an eternal change.
Mesjasz utknął w Samborze, czyli jak (nie) powstawał "Mesjasz" Brunona Schulza
Authors: Kulak Agata
Published: November 2023

Bruno Schulz’s Messiah is one of the most sought after manuscripts of all times. Schulz hinted at working on it on many occasions. Although the novel was supposed to unlock the author’s “iron capital of the spirit,” there is no proof that it was ever written. This paper is a detailed examination of Schulz correspondence thanks to which we can see Messiah’s birth: both the Messiah who existed in Schulz’s imagination and the one who was to appear on paper. The journey through the letters is very sad indeed, because one can observe the author’s inner struggle which leads to his spiritual death many years before the physical one. This paper tells a story of Schulz’s challenges (lack of time, unrealistic expectations, and his poor mental health), being also an attempt to familiarize the reader with a sad conclusion – Messiah does not exist.
Hacia un nuevo radar. Arte urbano e identidades barriales en la ciudad de Buenos Aires
Authors: González Bracco Mercedes
Published: November 2023

En los últimos años hemos asistido a un desarrollo exponencial del arte urbano a nivel global. Múltiples trabajos destacan su vinculación al marketing de ciudades, como estrategia que se suma a otras en la competencia global por atraer inversiones. No obstante, también es posible encontrar otras motivaciones que responden a cuestiones identitarias en términos de marcar un lugar como propio. En torno a esta última idea, el objetivo de este artículo es analizar cómo el arte urbano se entrelaza con la identidad local, reorganizando el espacio barrial y los imaginarios a él asociados en la ciudad de Buenos Aires. A partir de un abordaje antropológico que incluye observaciones y entrevistas, así como relevamiento de bibliografía, prensa y redes sociales, se indaga acerca de las diversas necesidades, expectativas y estrategias a las que responde la elaboración de murales en contextos comunitarios.