bluuebunny/crossref_metadata_2025 huggingface dataset:
TYROSINEMIA I TYPE (LITERATURE REVIEW) WITH A DESCRIPTION OF THE CLINICAL CASE
Authors: Kuznetsova M. A. , Zryachkin N. I. , Tsareva Yu. A. , Zueva E. I.
Published: February 2020

Modern ideas about the most severe variant of hereditary tyrosinemia are reflected -- its first type related to orphan diseases (the population frequency of occurrence is 1: 100,000-120,000 live newborns). The latest data on etiology is highlighted (mutations in the gene for the enzyme fumarylacetoacetase (FAA), leading to a deficiency of fumarylacetohydrolase (FAH), the last enzyme in tyrosine catabоlism; the genetic mutation is localized on human chromosome 15q23-q25 and consists of 14 exons) and the mechanisms of development of the disease ( the bypass abnormal pathway of tyrosine metabolism with the formation of highly toxic and carcinogenic metabolites -- succinyl acetoacetate (SAA) and succinylacetone (SA), others; substrate accumulation mainly in FAH-deficient hepatocytes and proximal renal tubule cells; violation of the processes of gluconeogenesis, ammonia detoxification and hepatic protein synthesis), which determine different clinical variants and symptom polymorphism. A modern classification of type I tyrosinemia and a detailed protocol for diagnostic examination of the patient, including instrumental methods, laboratory monitoring of highly toxic derivatives of the tyrosine metabolic pathway and molecular genetic studies, are presented. Denotes a range of diseases that should be carried out a differential diagnosis of tyrosinemia. The modern concept of treatment of this orphan disease (protein-free diet, specialized amino acid mixtures, hepatoprotectors, vitamin D and others) is laid out with an emphasis on enzyme replacement therapy with nitisinone, an enzyme inhibitor (4-hydroxyphenylpyruvate dioxygenase) of the first phase of tyrosine degradation. A description of a clinical case and a 15-year-old teenager with a hereditary tyrosinemia type I who received a low protein diet, the amino acid mixture «XPHEN TYR Tyrosidone» (Nutricia) and nitisinone (Orfadin®).
SCIENTIFIC BASES OF HYGIENE AND HEALTH OF CHILDREN AND ADOLESCENTS (TO THE 60TH ANNIVERSARY OF THE INSTITUTE OF HYGIENE AND CHILD AND ADOLESCENT HEALTH)
Authors: Kuchma Vladislav R
Published: February 2020

60 years of the work of the Scientific and Research Institute of Hygiene and Health Protection of Children and Adolescents of the National Medical Research Center of Children’s Health, 2, bld. 1, Lomonosov avenue, Moscow, 119991, Russian Federation of the Ministry of Health of Russia provide an analysis of research directions, their achievements and use in health care and education. A series of discoveries, basic and applied research in the field of hygiene of children and adolescents, ensuring the sanitary and epidemiological well-being of the children’s population allowed to substantiate the modern system of hygiene and child and adolescent health, prevention of the most common diseases, school-related diseases and conditions, including population and personalized levels, and effective technologies to ensure them. Effective models of medical care for students in educational institutions, the activities of schools promoting health have been developed. Fundamental guidelines have been prepared for physicians on the hygiene of children and adolescents, school medicine, and medical support for students in educational institutions. Primary in the development and improvement of the hygiene of children and adolescents are the following: modernization, re-equipment of material and technical base for research; attracting young, talented and dedicated researchers; ensuring safe life and adaptation of children and adolescents in the context of global digitalization, including safe goods and services for children and adolescents, as part of the new scientific and technological development strategy of the country; constant monitoring of the development of hygienic science and correction of plans for basic and applied research in the field of hygiene and child and adolescent health.
KOVRIGINA MARIYA DMITRIEVNA «IS PERSONALLY RESPONSIBLE FOR THE HEALTH OF THE COUNTRY’S CHILDREN AND WOMEN» DURING THE GREAT PATRIOTIC WAR
Authors: Goncharova Svetlana G.
Published: February 2020

There is shown the role of the USSR People’s Health Committee in solving one of the most important tasks facing the Soviet state during the war years to preserve the health of children and women. The personal contribution of the prominent health care organizer M.D. Kovrigina in protecting the health of children and women during the Great Patriotic War is highlighted. Despite the dire consequences of the first years of the war, the People’s Commissariat of Health of the USSR was able to prevent the development of epidemics among children and gradually restore the children’s health care system in the rear and in the territories liberated from occupation. M.D. Kovrigina actively participated in the development and implementation of the most important decrees of the party and Soviet bodies on the protection of the health of children and women. Thanks to the establishment of strict control over the implementation of legislative decisions and decisions of the People’s Commissariat of Health of the USSR M.D. Kovrigina managed to restore the district system and raise the level of medical care for children.
SPECIES DIVERSITY AND SENSITIVITY TO ANTIBIOTICS AGAINST ORAL STREPTOCOCCI ISOLATED IN CHILDREN
Authors: Mayanskiy N. A. , Kvarchiya A. Z. , Brzhozovskaya E. A. , Ponomarenko O. A. , Kryzhanovskaya O. A. , Kulichenko Tatyana V.
Published: February 2020

Oral streptococci can exchange genetic material with other bacteria colonizing the same loci of the body, their resistance profiles can serve as markers of the risk of the developing resistance to certain antibiotics in closely related bacteria, in particular, Streptococcus pneumoniae. Materials and Methods To describe the species composition of oral streptococci and to detect the profile of their sensitivity to a wide range of antibiotics there were investigated oral streptococcal isolates isolated from oropharyngeal smears sown in children of various ages with acute respiratory infections not receiving antibacterial therapy for selective streptococcal medium with penicillin (Pen, 1 mg/l) or erythromycin (Ery, 2 mg/l). 253 oropharyngeal smears were studied. Results. The most frequent sowings were Pen-resistant and Ery-resistant Streptococcus mitis, found in 158 (62.5%) and 169 (66.8%) studied, respectively. Ery-resistant Streptococcus salivarius group was detected in 107 (42.3%) samples, Pen-resistant streptococcus from this group were found much less frequently in 16 (6.3%) samples. Pen and Eri-resistant isolates of Streptococcus sanguinis group were present in 69 (27.3%) and 49 (19.4%) samples respectively. All the streptococcus specimens studied were sensitive to vancomycin, linezolid and (except for one) levofloxacin; about 90% were sensitive to daptomycin, rifampicin and chloramphenicol. Sensitivity to tetracycline was lower at 57.5%. Multiple drug resistance (MDR; resistance to ≥3 groups of antibiotics) had 93 (58.1%) isolates; the most common combination of penicillin, erythromycin and tetracycline resistance was found in 53 (57%) MDR isolates. Streptococcus mitis/oralis were characterized by higher MPCs of penicillin, ampicillin and ceftriaxone, as well as the frequency of stable forms, including MDR, as compared to other streptococci. Streptococcus mitis, first S. mitis oralis group streptococcus predominate in the species structure of antibiotic-resistant oral streptocococci, among which MDR is widespread, including resistance to β-lactams.
INTRACARDIAC THROMBOSIS IN CHRONIC HEART FAILURE CHILDREN WITH CARDIOMYOPATHY WITH DILATED PHENOTYPE
Authors: Derevnina Yuliya V.
Published: February 2020

Systolic dysfunction and dilatation of the left ventricle in cardiomyopathy patients contribute to the formation of intracardiac thrombosis, especially against the background of hypercoagulation. To determine the predictors of thrombotic complications and the incidence of intracardiac thrombosis in chronic heart failure patients suffered from cardiomyopathy with dilated phenotype there were examined 100 children aged from 1 month to 18 years. In all patients, there was made an assessment of indices of the hemostasis system, molecular genetic examination, including studies of polymorphic markers of hemostasis system genes, as well as folate cycle genes by the method of polymerase chain reaction (real-time). It was established that thrombosis was observed in 11% of children with a 2B-3 stage of heart failure clinic and a functional class (FC) of 3-4, a systolic dysfunction with an ejection fraction below 40% against the background of hypercoagulation of the plasma link of hemostasis. Analysis of genetic markers showed that risk of thrombotic complications to be 5 times higher for carriers of the pathological allele A of the FII gene among chronic heart failure patients suffered from cardiomyopathy with a dilated phenotype. Patients with severe systolic dysfunction have been prescribed prophylactic antithrombotic therapy to achieve an adequate therapeutic range (for anti-Xa factor activity and platelet hypoaggregation).
MATRIX METALLOPROTEINASES IN CHILDREN WITH A COMBINED BONE INJURY
Authors: Smirnov Ivan E. , Roshal L. M. , Mitish V. A. , Kucherenko A. G. , Karaseva O. V. , Ponina I. V.
Published: February 2020

There were comprehensively examined 55 children, including 35 children with combined bone injury (average age of 12.6 ± 2.3 years), reference group consisted of 20 apparently healthy children (average age of 11.8 ± 2.7 years) without pathology of the motor system. on the 1-3rd and 30th day after the combined bone injury, changes in the content of matrix metalloproteinases (MMP) and cytokines - transforming growth factor-beta (TGF-β), monocytic chemotactic factor (MCP-1) and macrophage inflammatory protein (MIP-1β) were followed in the dynamics by serum immunoassay determination. It was established that after combined bone injury at the stage of post-traumatic formation of the regenerate by 30th days the serum concentrations of gelatinases (MMP-2, MMP-9) and collagenases (MMP-8) significantly increased, the levels of stromelysins (MMP-3) did not change, and the content of TIMP-1 decreased. Early detection of changes in the blood content of bone biomarkers during the recovery process after a combined trauma in children allows the timely implementing the correction of disturbances and the choice of the optimal individual treatment tactics for a particular patient, taking into account the features of his bone metabolism.
PHYSICAL DEVELOPMENT OF ADOLESCENTS WITH THE SYNDROME OF AUTONOMIC DISORDERS LIVING IN THE MIDDLE MOUNTAIN ZONE OF THE REPUBLIC OF DAGESTAN
Authors: Aliev Khadzhimurad A. , Aliskandiev A. M. , Izrailov M. I. , Aliskandiyeva Z. A. , Abdulmuslimov M. T.
Published: February 2020

An evaluation of the physical development of children and adolescents with the syndrome of autonomic dysfunction (SAD) was performed. There were examined 329 SAD children and adolescents aged 11 to 17 years (boys: 138-41.9%, girls: 191-58.1%) residing in the middle mountain zone of the Republic of Dagestan (RD). In all cases there were evaluated such basic anthropometric data as: body length and weight, chest circumference, BMI according to WHO criteria. An evaluation of the physical development of adolescents with ADS living in the middle mountain zone of RD revealed the prevalence of a mesosomatic type of the development in 72.1% of adolescents, microsomia was detected in 18.6% of cases, while macrosomia observed in 9.3% of the adolescents. A high incidence of disharmonious development was found in 39.3%, while pronounced dishormonal physical development as found in 2.1% of adolescents. A comparative analysis of the physical development of SAD adolescents with indice of the physical development according to WHO criteria according to BMI showed SAD children significantly to delay at the age of 12, 15,16,17, but an unreliable lag was observed at the age of 11 and 13 years.
Neural Model for the Prediction of Volume Losses in the Aging Process of Rums
Authors: García-Castellanos Beatriz , Pérez-Ones Osney , Zumalacárregui-de-Cárdenas Lourdes , Blanco-Carvajal Idania , López-de-la-Maza Luis Eduardo
Published: February 2020

The rum aging process shows volume losses, called wastage. The numerical operation variables: product, boardwalk, horizontal and vertical positions, date, volume, alcoholic degree, temperature, humidity and aging time, recorded in databases, contain valuable information to study the process. MATLAB 2017 software was used to estimate volume losses. In the modeling of the rum aging process, the multilayer perceptron neuronal network with one and two hidden layers was used, varying the number of neurons in these between 4 and 10. The Levenberg-Marquadt (LM) and Bayesian training algorithms were compared (Bay) The increase in 6 consecutive iterations of the validation error and 1,000 as the maximum number of training cycles were the criteria used to stop the training. The input variables to the network were: numerical month, volume, temperature, humidity, initial alcoholic degree and aging time, while the output variable was wastage. 546 pairs of input/output data were processed. The statistical Friedman and Wilcoxon tests were performed to select the best neural architecture according to the mean square error (MSE) criteria. The selected topology has a 6-4-4-1 structure, with an MSE of 2.1∙10-3 and a correlation factor (R) with experimental data of 0.9898. The neural network obtained was used to simulate thirteen initial aging conditions that were not used for training and validation, detecting a coefficient of determination (R2) of 0.9961.
Lactate Level as a Prediction Factor of Reperforation after Repairing Gastric Perforation
Authors: Budipramana Vicky Sumarki
Published: February 2020

Reperforation after gastric perforation repair is a complication which increases the rate of morbidity and mortality in gastric perforation. The lack of ability of the tissue to use oxygen in septic condition causes anaerobic cellular metabolism and furthermore it will cause failure in closing the perforation. The production of anaerobic metabolism is lactic acid which can be measured from the blood. The aim of this study is to determine the cut-off point of blood lactate level as a predictor of reperforation after repairing gastric perforation. Forty-six patients diagnosed as gastric perforation, who were repaired in Dr Soetomo Hospital from October 2014 to October 2015 were recruited as samples. Serum lactate was taken one hour before repairing the perforation. After being repaired, the patients were observed until the 14th day to evaluate whether any reperforation would occur or not . The design of this research was cross-sectional, analytic observational. The data was analyzed using independent t-test and ROC for obtaining the cut-off point as a predictor of the reperforation after the gastric perforation was repaired. There was a significant difference in the mean of lactate level in the group with reperforation compared with that of the non-reperforation group, that is as big as 3.74±0.59 mmol/L and 2.60±0.76 mmol/L. Using ROC curve analysis, there was the cut-off point of lactate level for reperforation 3.35 mmol/L, with sensitivity 92.9%, specificity 84.4%, positive predictive value 72% and negative predictive Value 96.4%, accuracy 87.0% and in the AUC value 0.902.
Case report: Thrombocytopenia in a Patient Undergoing Primary Percutaneous Coronary Intervention
Authors: Oktaviono Yudi Her , Meuthia Feranti
Published: February 2020

Thrombocytopenia is a common abnormality in patients presenting with acute coronary syndrome. Baseline thrombocytopenia in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention is associated with early adverse events, related to both ischemia and bleeding. Treatment for acute coronary syndrome usually involves antiplatelet, anticoagulant, antithrombotic therapy, and the performance of percutaneous coronary intervention. The safety of antiplatelet therapy and percutaneous coronary intervention patients who have acute coronary syndrome and thrombocytopenia is unknown, and there are no guidelines or randomized studies that specifically suggest a treatment approach in such patients. One of the institutions in Italy recommends medical and interventional strategy with radialis as first choice for access site, bare metal stent (BMS) implantation, followed by double antiplatelet therapy (DAPT) for one month. After DAPT discontinuation, at least one antiplatelet drug (aspirin) is recommended for life.
Correlation of Total IgE Level and Intensity of Infection among Soil Transmitted Helminthiasis Farmers in Klungkung Regency, Bali, Indonesia
Authors: Apsari Putu Indah Budi , Arwati Heny , Dachlan Yoes Prijatna
Published: February 2020

The phenomena of increasing total IgE level in Soil Transmitted Helminthiasis and its protective role in resistance of infection remains unclear. The purpose of this study was to determine the correlation between total IgE and the intensity of Soil transmitted helminthiasis among farmers in these area. Total 162 farmer, age ranged 25-80 years participated in this cross sectional analytic study. Kato-Katz method was used to diagnose Soil Transmitted Helminthiasis and to determined infection intensity based on egg per gram (EPG). Total IgE levels were measured by enzyme linked flourescent assay (ELFA). The results of this study showed that 13,56% farmer positive  for Soil Transmitted Helminthiasis, with single infection of Ascaris lumbricoides were 1,85%, 9,26% for Trichuris trichiura, 0,61% for Hookworm and mixed infection that were 1,23% for A.lumbricoides+T.trichiura 0,61%  for A.lumbricoides+Hookworm. The intensity of infection were in mild category. Total IgE level in Soil transmitted Helminthiasis group was significantly different compared with noninfected group (p<0.05, t-test). There was significant correlation between EPG and total IgE level (r=0.667, p=0.001, Spearman test). As a conclusion total IgE level was significantly correlated with EPG, this fact can be used to develop management of Soil Transmitted Helminthiasis theraphy.
Effects of Golden Sea Cucumber Extract (Stichopus Hermanii) on Fasting Blood Glucose, Plasma Insulin, and MDA Level of Male Rats (Rattus Norvegicus) Induced with Streptozotocin
Authors: Prawitasari Dita Sukmaya , Safitri Indri , Notopuro Harianto
Published: February 2020

Diabetes mellitus (DM) is one of disease that its incidence increases every year worldwide. The condition of DM can cause various complications caused by oxidative stress. Stichopus hermanii (SH) or golden sea cucumber extract contains antioxidant compounds that have been proven to reduce oxidative stress conditions. The purpose of this study was to investigate the effect of Stichopus hermanii extract on condition of diabetes mellitus by looking at changes in fasting blood glucose, plasma insulin, and malondialdehyde levels in animal models of Wistar rats. This study was a laboratory experimental study using Randomized Control Trial Design with Post-test only control group design. Thirty-five male Wistar rats divided into five groups, i.e normal control group, positive control, negative control and two treatment groups with SH extract dose 8.5 and 17 mg / kgBW for 14 days once daily after induction of Streptozotocin at the Biochemistry Laboratory of the Faculty of Medicine, Airlangga University. Fasting blood glucose level was measured by a glucometer, plasma insulin measured by ELISA and MDA level was measured by a spectrophotometer. Data were analyzed statistically by using One Way ANOVA test and Kruskal Wallis. There were significant results of SH extract can reduce fasting blood glucose (Kruskal Wallis, p=0.030) and MDA (Kruskal Wallis, p=0.042) but not in plasma insulin (ANOVA, p=0.130). The lowest MDA level occurs in the K4 group that given SH extract dose 17 mg/kg BW than another experimental group. As the conclusion, this study showed SH extract can decrease fasting blood glucose and oxidative stress in diabetic-induced rats.
Effect of Different Complementary Feeding on Iron Deficiency Anemia and Growth in Breastfed Infants: Home-Made VS Commercial
Authors: Irawan Roedi , Widjaja Nur Aisiyah , Hanindita Meta Herdiana
Published: February 2020

After approximately 6 months of age, term breastfed infants are increasingly depend on other sources of iron to avoid iron deficiency anemia, due to the depletion of the low concentration of iron in human milk. The appropriate complementary feeding must include a balance composition of foods containing an adequate amount of macro- and micronutrients to avoid iron deficiency anemia. This study aimed to compare the risk of iron deficiency and growth in breastfeed infants receiving commercial fortified complementary foods or home-made. A cross-sectional study was held on April-June 2016 to evaluate infants aged 6-24 months with breast feeding intake for 6 month of life. Complementary feeding practices were determined by questionnaire; an unquantified food frequency and feeding practices questionnaire was used to determine usual food intake. Biochemical assessment of haemoglobin (Hb), serum ferritin (SF) and serum iron (SI) level were measured. Anthropometric were assessed using WHO Child Growth Standard 2005. Statistical analysis used were Chi-square Test. Thirty eight infants were enrolled, mean age of 16.2 (SD 10.5) months. 17 infants consumed commercial complementary foods and 21 infants use home-made. Infants with home-made had lower Hb level, SF and SI  than those receiving commercial complementary food, and had higher risk of underweight, stunted and wasted. Infants with home-made complementary food had lower haemoglobin, serum feritin and serum iron levels than those in fortified complementary food CF; and a higher risk of stunted and wasted than children with commercial fortified CF.
Quality of Life of Diabetic Foot Ulcer Patients with Hyperbaric Oxygen Therapy
Authors: Kusnanto Kusnanto , Dismalyansa Dismalyansa , Pradanie Retnayu , Arifin Hidayat
Published: February 2020

DM with ulcer can result in a decrease in the quality of life of patients and need to reduce the intensity of pain and odor on the ulcer, preventing amputation and Hyperbaric Oxygen as an adjuvant therapy in accelerating wound healing. This study aims to explain the effect of HBO on the quality of life of patients with diabetic foot ulcers at RSAL Dr. Ramelan Surabaya. Methods: The research used quasi-experimental design with a non-equivalent control group design approach. The samples were 70 patients from population of all diabetes patients who suffered from diabetic foot ulcers at RSAL Dr. Ramelan. Data were collected by WHOQOL-BREF questionnaire. Analyzed byWilcoxon signed rank test and Mann Whitney U test. Result: Mann Whitney in the post test, the physical p-value domain (0.000), psychological domain (0.012), social domain (0.003), and environmental domain (0,001), where the intervention group has a better value than the control group. Wilcoxon signed rank test results on the physical domain (0,000), psychological (0,012), social (0,003), and environmental (0,001), meaning there were significant differences between pre post test in intervention group. Discussion: Diabetes mellitus patients with foot ulcers given hyperbaric oxygen showed improvement on wound condition, thus reducing pain and medical needs. This makes patients motivated, reduce anxiety, and improve interpersonal support and confidence. Therefore, it is necessary to socialize the effect of HBO on DM patients with foot ulcer, as a treatment option in improving the quality of life of DM patients with foot ulcers.
Effect of In-Vitro Alpha Lipoic Acid Addition on Spermatozoa Motility in Sperm Preparation Process
Authors: Buanayuda Gede Wira , Lunardhi Hamdani , Mansur Indra Gusti
Published: February 2020

Infertility is a problem for husband and wife, in the last 20 years the number of infertile couples has tended to increase by around 6.5 million pairs. The infertile couple can use the intrauterine insemination method to obtain offspring if a conventional method approach cannot be performed. Insemination requires a sperm preparation stage in which there are centrifugation and resuspension procedures that tend to produce excess reactive oxygen species (ROS). Excessive ROS will damage the motility of the spermatozoa. This study aims to prove the addition of alpha lipoic acid (ALA) as an antioxidant in the process of sperm preparation to improve and maintain better sperm motility. This research is a laboratory study with an experimental research design. The sample consisted of 10 infertile men who visited the Andrology section of the Sayyidah Jakarta Mother and Child Hospital (RSIA), where each ejaculate from the patient would be divided into 3 groups namely (k1) fresh semen as a control group, (k2) sperm preparation group without ALA, (k3) group of sperm preparation with the addition of ALA. The motility of spermatozoa was observed with the WHO 1999 method for 4 hours in units of percent. Progressive motility in k3 (47.95 ± 3.617) was higher than in k2 (38.05 ± 3.278) statistically significantly different after 3 hours of observation (p<0.0001). Progressive motility in k3 (78.8 ± 5.841) was higher than k1 (56.55 ± 7.511) from the initial observation (p <0.0001). The progressive motility of k2 (76.05 ± 6.768) was higher than k1 (56.55 ± 7.511) from the start of the observation (0.0001). It can be concluded that the addition of ALA in the sperm preparation process increases and maintains progressive motility that is better than sperm preparation without ALA addition after 3 hours of observation.
PENINGKATAN PENDAPATAN KELOMPOK TANI PADI ORGANIK MELALUI PROGRAM MANDIRI BENIH DI DESA KETAPANG KECAMATAN SUSUKAN SEMARANG
Authors: Supriyadi Supriyadi , Sumani Sumani , Purwanto Purwanto , Mustofa Mustofa
Published: February 2020

Background, excessive exploitation of paddy land in the long term without the addition of organic matter have resulted in soil become damaged. To meet the needs of food (rice) healthy and improve the functioning of the land, then there is no best alternative except development of organic farming systems. To be able to implement a system of organic farming, it is necessary to aplication of seed quality assurance. IbPUD activities carried out ini the village Ketapang, local village government has formed group of paddy organic farmers, but due to constraints in the available of seed rice organic . The purpose, carry out assistance to Farmers and Farmers Group in the establishment of the sources of seed organic rice and the acquisition of organic certification. The method, is Focus Group Discussion which emphasizes dialogue interpersosnal and mentoring. The program is implementing educational methods that involve the active participation of the participants from the three (3) groups of paddy organic farmers partners in Ketapang. The training was held in the form of : (1) seed rice breading management trainin, (2) training of organic rice management with the use of local waste and can be as alternative of organic fertilizers, and (3) training buines management.Results, an increasing number of farmers' groups who implement sources of seed organic rice of 4 (four) varietas (Mentik Susu, Mentik Wangi, Hitam Arang and Merah Anoman) to 3 farmer groups (15Ha). In conclusion, most members of the Farmers Group Al-Barokah have felt: (a) the benefit of the treatment of organic in terms of soil quality and the products of organic rice and its by-products, (b) an increase in value-added organic products and farmers' income, (c) the importance of maintaining paddy according to its function, (d) have become independent farmers in organic rice cultivation.
Keywords: Organic farming systems, Organic certification, Interpersonal dialogue
IbM PENINGKATAN POTENSI EKOWISATA DI DESA JATIREJO KECAMATAN NGARGOYOSO KABUPATEN KARANGANYAR MELALUI PENGEMBANGAN OLAHAN JAMBU BIJI MERAH SEBAGAI OLEH-OLEH KHAS DESA WISATA JAMBU BIJI MERAH
Authors: Utami Rohula , Ishartani Dwi , Khasanah Lia Umi
Published: February 2020

Ecotourism is currently growing rapidly. This type of tourism is environmentally friendly tourism that promotes the aspects of nature conservation, socio-cultural empowerment, and local community economy, as well as aspects of learning and education. Several local governments seized this opportunity, among them is Karanganyar. Jatirejo Village in Ngargoyoso Subdistrict is one of the villages in Karanganyar which developed as ecotourism destination by exploiting its local potency, that is red guava cultivation. To strengthen the image of Jatirejo Village as the Red Guava Tour Village, it needs several development strategies, among them creating a unique souvenir by utilizing local potency. In this activity is conducted red guava processed development as souvenir typical of Red Guava Tour Village. Partners coupled in this activity is SME (Small Medium Enterprise) Putra Jambu currently processing red guava fruit into ice cream and Kelompok Makmur Candi Tani who currently cultivate the red guava and process the red guava leaves into chips. Both SMEs have constraints in the form of limited production technology, resulting in inconsistent product quality, short shelf life, low production capacity and narrow marketing reach, and limited marketing. The first activities of IbM were accompanied the SMEs to prepare the Standard Operation Procedure (SOP). Introduction of packaging and improvement of labeling on red guava leaf chips also have revealed by this program. Several production equipments also introduced to the SMEs such as ice cream maker machine, automatic sealer, and ice cream distribution equipment (freezer). This program also conducted training and marketing assistance. With this activity, there is an improvement of product quality, performance efficiency improvement, and market expansion of SME Putra Jambu and Farmers Grup Candi Makmur.
Keywords: ecotourism, red guava, Karanganyar, Ngargoyoso, Souvenirs
MUHASEBE BİLGİ SİSTEMİNİN KOBİ’LERDE FARKINDALIĞI ÜZERİNE BİR ARAŞTIRMA: ISPARTA İLİ ÖRNEĞİ
Authors: ÖZÇELİK Hakan , KILINÇ Zehra
Published: February 2020

Teknolojideki değişime paralel olarak değişerek gelişen günümüz rekabet ortamlarında, işletmelerin kaliteli bilgiye olan ihtiyaçları artmaktadır. Muhasebe bilgi sistemi, KOBİ’lerin ihtiyaç duyduğu muhasebe bilgilerini üreten alt bilgi sistemidir. İyi tasarlanmış ve işletmenin organizasyon yapısına entegre edilebilmiş muhasebe bilgi sistemi, KOBİ’lerin hedeflerine ulaşmasını kolaylaştıracaktır. Çalışmanın amacı, KOBİ’lerde muhasebe bilgi sisteminin unsurları, işleyişi, raporları ve katkıları açısından farkındalığının tespit edilmesidir. Amaç doğrultusunda, Isparta’da faaliyet gösteren KOBİ yönetici ve çalışanları üzerine anket uygulanmıştır. Veriler ve çalışma kapsamında geliştirilen hipotezler, SPSS programında analiz edilmiştir. Çalışmanın analiz kısmında, KOBİ’lerde muhasebe bilgi sisteminin unsurları, işleyişi, raporları ve katkıları konularında yönetici ve personellerin görüşleri ve görüşleri arasında farklılıkların olup olmadığı analiz edilmiştir. Çalışma sonucunda, KOBİ muhasebe bilgi sistemleri ile ilgili görüşler değerlendirilmiş ve katılımcıların görüşleri arasında istatiksel açıdan anlamlı farklılıklar olduğu tespit edilmiştir. Sonuçlar doğrultusunda, KOBİ’lerde muhasebe bilgi sisteminin etkinliğinin artırılabilmesi için önerilerde bulunulmuştur.
LİSE ÖĞRENCİLERİNİN BEDEN ALGISI VE YEME TUTUMUNUN İNCELENMESİ VE BUNLARIN BKİ (BEDEN KİTLE İNDEKSİ) İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ
Authors: ARSLAN Müge
Published: February 2020

Bu çalışma lise öğrencilerinin beden algısı ve yeme tutumunun incelenmesi ve bunların BKİ ile ilişkisinin değerlendirilmesi amacıyla yapılmıştır. Tanımlayıcı tipte bir çalışmadır. Araştırmanın çalışma grubu; İstanbul Kadıköy Fenerbahçe Anadolu Lisesinde okuyan 721 lise öğrencisinden oluşmaktadır. Araştırmada katılımcılara, katılımcıların demografik özelliklerini, beslenme durumlarını sorgulayan sorular, beden algısı ölçeği ve yeme tutumu ölçeğinden oluşan anket uygulanmıştır. Katılımcıların BKİ değerleri ile yeme tutumları arasında anlamlı fark saptanmış olup yeme tutumu en bozuk olan grup %70.0 ile (21 kişi) obezlerdir. Katılımcıların beden algısı ve yeme tutumları arasında anlamlı fark olup, beden algısı düşük olanların, yeme tutumu bozulmuştur. Katılımcıların sınıf dağılımları ile yeme tutumları arasında anlamlı fark olup yeme tutumu en bozulmuş olan sınıflar %66.9 ile (85kişi) 11. sınıf ve %65.6 ile (84 kişi) 12. sınıflardır. Katılımcıların nerdeyse yarısının beden algısı düşüktür ve beden algısı en düşük sınıf %78.9 ile (101 kişi) 12. sınıftır. Beden algısı en düşük olan BKİ grubu ise %66.7 ile (20 kişi) obezlerdir. Bu bulgular ışığında varılan sonuç lise öğrencilerinin genelinin beden algısı düşüktür ve yeme tutumları bozulmuştur. Obezler en fazla yeme tutumu bozulmuş olan gruptur. Beden algısı düşük olanların yeme tutumları bozulmuş ve BKİ’leri yüksektir.
BANKALARIN SÜRDÜRÜLEBİLİRLİK ENDEKSİNE DAHİL EDİLMELERİNİN HİSSE SENEDİ GETİRİLERİ ÜZERİNDEKİ ETKİSİ
Authors: GÖK İbrahim Yaşar , GÖKŞEN Handan
Published: February 2020

Bu çalışmada, Borsa İstanbul Sürdürülebilirlik Endeksinde (XUSRD) işlem gören bankaların endekse dâhil edilme duyurularının, getiri üzerindeki etkilerinin olay çalışması yöntemiyle araştırılması amaçlanmıştır. Çalışma, XUSRD’de Kasım 2014 – Ekim 2019 arasında yer alan sekiz bankayı kapsamaktadır. Ortalama anormal getirilerin genel olarak duyuru öncesi negatif ve duyuru sonrasında ise pozitif olduğu belirlenmiştir. Kümülatif ortalama anormal getiriler (CAAR), olaydan 10 gün öncesinden olay gününe kadar negatif olarak giderek artmakta, olaydan gününden itibaren ise toparlanma başlamakta ve olaydan 10 gün sonrasında ilk kez pozitif değere ulaşmaktadır. Olaydan 10 gün sonrası ve 10 gün öncesindeki CAAR değerleri arasındaki ortalama fark pozitiftir ve istatistiksel olarak anlamlıdır. (0, +1), (0, +2) olay penceresi aralığındaki CAAR değerleri pozitif olmasına rağmen sıfırdan anlamlı bir şekilde farklılaşmazken, (0, +3) periyodundan (0, +10)’a kadar olan CAAR değerleri pozitiftir ve sıfırdan anlamlı bir şekilde farklıdır. Bu bulgular, bankaların XUSRD’ye dâhil olmalarının, yatırımcılar nezdinde pozitif bir etki oluşturduğuna işaret etmektedir.
DETERMINATION OF PROFESSIONALISM AND TRANSPARENCY AND ITS IMPLICATIONS FOR THE FINANCIAL PERFORMANCE OF ZAKAT INSTITUTIONS
Authors: Nasri Rifzaldi , Aeni Nur , Haque Marissa Grace
Published: February 2020

The objective of this study is to determine the influence of the professionalism and transparency of zakat management on financial performance, especially in the case of the Amil Zakat Institution of Daarut Tauhid Peduli Jabodetabek. The method used in the research is SEM (structural equation modeling) using AMOS, with 156 respondents. The results show that: (1) professionalism has a negative and insignificant impact on the transparency of zakat management; (2) professionalism has a positive and significant impact on financial performance; and (3) the transparency of zakat management has positive and significant impacts on financial performance. Moreover, the indicators of competence have the highest loading factors of professionalism; the indicator of information on fund management has the highest loading factors of transparency; while the indictor of measurement of economics has the highest loading factor of financial performance. To sum up, this research suggests that zakat institutions should improve their transparency and professionalism in order to improve their financial performance in the future.
Rifampin Combination Therapy in Staphylococcal Prosthetic Joint Infections: A Randomized Controlled Trial
Authors: Karlsen Øystein , Borgen Pål , Bragnes Bjørn , Figved Wender , Grøgaard Bjarne , Rydinge Jonas , Sandberg Lars , Snorrason Finnur , Wangen Helge , Witsø Eivind , Westberg Marianne
Published: February 2020

Background The evidence supporting rifampin combination therapy in prosthetic joint infections (PJI) is limited due to the lack of controlled studies. The aim of this study is to evaluate the effect of adding rifampin to conventional antimicrobial therapy in early staphylococcal PJIs treated with debridement and retention of the implant (DAIR). Methods In this multicentre randomized controlled trial, 99 patients with PJI after hip and knee arthroplasties were enrolled. They were randomly assigned to receive rifampin or not in addition to standard antimicrobial treatment with cloxacillin, or vancomycin in case of methicillin resistance. The primary end point was no signs of infection after 2 years follow-up. Results 48 patients were included in the final analyses. There were no differences in patient characteristics or co-morbidities between the two groups. There was no significant difference in remission rate between the rifampin combination group (17 of 23 (74%)) and the monotherapy group (18 of 25 (72%), relative risk 1,03, 95% confidence interval 0,73 to 1,45, p=0.88). Conclusion Our study has not proven a statistically significant advantage by adding rifampin to the antibiotic treatment in staphylococcal PJIs.
Psycho-Sexual Influence of Sterilization on Women’s Quality of Life: A Path Model
Authors: Youseflu Samaneh , Sadatmahalleh Shahideh Jahanian
Published: February 2020

Background: This study aimed to test a conceptual model considering the interrelated role of menorrhagia, body image concern, self-esteem, anxiety and depression, sexual function, on quality of life (QOL) of sterilized women.Methods: The current study was conducted as a retrospective cohort study on 200 sterilized women. Data were collected using a socio-demographic checklist, Short Form Health Survey (SF-12), Pictorial Blood Loss Assessment Chart (PBLAC), Female Sexual Function Index (FSFI), Hospital Anxiety and Depression Scale (HADS), Body Image Concern Inventory (BICI), and Rosenberg Self-Esteem Scale.Results: Results show that anxiety (β =-0.51), sexual function (β =0.15) self-esteem (β =0.15), and body image dissatisfaction (β = -0.10) have a direct effect on women’s QOL. Higher level of anxiety, body dissatisfaction with direct effect can be reduce QOL. Anxiety (β =-0.05), sexual function (β =0.20), and menorrhagia (β =-0.09) with indirect effect impress QOL. Higher level of anxiety with indirect effect thorough self-esteem can worsen QOL (β =-0.05).Conclusion: Regarding the psycho-sexual influence of sterilization on women’s QOL, a comprehensive consultation about the negative consequence of sterilization before TL, and psychotherapeutic and psychosexual help after sterilization should be offered.
Lyssavirus Spp. – Rabies Viruses As A Still-Present Problem
Authors: Gałązka Przemysław , Kaczor Patryk , Grzelakowska Klaudyna , Leis Kamil
Published: February 2020

The genus Lyssavirus spp. currently includes 14 species that are responsible for causing rabies, rabies-like and rabies-related diseases. The first symptoms of infection are similar to a cold and mainly include fever, headache and general fatigue. Then comes brain dysfunction and acute neurological symptoms, and ultimately – in most cases – death. Lyssaviruses are spread mainly through direct contact with the carrier that contains the viral reservoir. The gold standard in diagnostics is the method of direct immunofluorescence, through which viral antigens are detected – mainly in the saliva of a patient. Currently, rabies treatment is an experimental form of therapy according to the Milwaukee protocol.

1. Introduction. 2. Systematics. 2.1. Lagos bat virus. 2.2. Mokola virus. 2.3 Duvenhage virus. 2.4. European bat 1 lyssavirus. 2.5. European bat 2 lyssavirus. 2.6. Australian bat lyssavirus. 3. Characteristics. 3.1. Molecular structure. 3.2. Genome and gene expression. 3.3. Life cycle. 4. Pathogenicity. 4.1. Pathogenesis. 4.2. Rabies symptoms. 5. Prevention, prophylaxis, diagnostics, treatment. 5.1. Vaccinations. 5.2. Postexposure prophylaxis. 5.3. Diagnostics. 5.4. Experimental treatment. 6. Summary
The Prevalence Of Symptomatic Dermatophytoses In Dogs And Cats And The Pathomechanism Of Dermatophyte Infections
Authors: Łagowski Dominik , Gnat Sebastian , Nowakiewicz Aneta , Osińska Marcelina , Zięba Przemysław
Published: February 2020

Dermatophytoses are skin diseases related to the infection of surface layers of skin and other keratinised structures such as hair and nails, caused by fungi referred to as dermatophytes. The scientific literature provides descriptions of over 50 dermatophytic species classified in the Trichophyton, Epidermophyton, Nannizzia, Arthroderma, Lophophyton, and Paraphyton genera. Dermatophytes are regarded as pathogens; they are not a component of skin microbiota and their occurrence in animals and humans cannot be considered natural. The review of the scientific literature regarding the occurrence and prevalence of dermatomycoses in companion animals revealed significant differences in the prevalence of the infections. Two main factors are most frequently assumed to have the greatest epidemiological importance, i.e. the animal origin and the type of infection. In this aspect, interesting data are provided by investigations of the fungal microbiota present in cat and dog fur. Interestingly, an anthropophilic species Trichophyton rubrum was found to be one of the species of dermatophytes colonising the skin of animals that did not present symptoms of infection. Is the carrier state of this species important in the epidemiology of human infections? Additionally, animal breeders and veterinarians claim that only certain breeds of dogs and cats manifest high sensitivity to dermatophyte infections. The pathomechanism of dermatophyte infections has not yet been fully elucidated; however, three main stages can be distinguished: adhesion of arthrospores to corneocytes, their germination and development of mycelium, and fungal penetration into keratinised tissues. Importantly, the dermatophyte life cycle ends before the appearance of the first symptoms of the infection, which may pose an epidemiological threat. Dermatophyte virulence factors include various exoenzymes, mainly keratinase, protease, lipase, phospholipase, gelatinase, and DNase as well as toxins causing haemolysis responsible for nutrient supply to pathogens and persistence in the stratum corneum of the host. Clinical symptoms of the infection are external manifestations of the dermatophyte virulence factors.

1. Introduction. 2. Dermatophytoses in dogs and cats. 2.1. Diagnostic problems in zoophilic dermatophytoses. 2.2. The prevalence of dermatophytosis in dogs and cats. 2.3. Factors predisposing to dermatophytosis. 2.4. Breed predilections in dermatophyte infections. 3. Pathogenesis and dermatophyte virulence factors. 3.1. Development of dermatophyte infection. 3.2. The pathogenesis of infection. 3.3. Dermatophyte virulence factors. 3.4. Clinical symptoms in canine and feline dermatomycoses. 3.5. Host immune response. 4. Summary
Exopolysaccharide-Producing Lactic Acid Bacteria – Health-Promoting Properties And Application In The Dairy Industry
Authors: Berthold-Pluta Anna M. , Pluta Antoni St. , Garbowska Monika , Stasiak-Różańska Lidia
Published: February 2020

Exopolysaccharides (EPS) are one of the classes of extracellular biopolymers synthesized by bacteria. Some strains of lactic acid bacteria (LAB) used in the dairy industry are able to synthesize EPS (EPS(+) strains). EPS may be secreted by a cell in the form of capsule or slime. Our review describes the factors influencing the activity of EPS production by LAB, the impact of the use of EPS(+) strains on the quality of fermented milk products (yoghurt, cheeses, etc.) and pro-health properties of EPS produced by LAB. The capability to synthesize EPS by LAB depends on many factors, e.g., affiliation to species and characteristics of strain, growth stage, composition of culture medium (type of carbon and nitrogen sources, and presence of other nutrients), temperature, pH, and presence of adjuvant microflora. The presence of EPS synthesized by LAB strains has a significant effect on changes in various properties of dairy products, including: yoghurt, kefir and many other fermented milk drinks, sour cream and cheeses. The EPS act as thickening, emulsifying and gelling agents, hence the use of EPS(+) strains may become a certain alternative to the use of thickeners in, e.g., fermented milks. During formation of a casein milk curd, EPS are able to bind water and thus reduce syneresis. The high water holding capacity of EPS has a positive effect on increasing viscosity and improving texture of low-fat cheeses. EPS are claimed to have health-promoting properties, like: anticarcinogenic, antioxidative, immunomodulatory and reducing blood cholesterol.

1. Introduction. 2. General characteristics of exopolysaccharides. 3. Factors affecting exopolysaccharides synthesis by lactic acid bacteria. 4. Effect of exopolysaccharides on the quality of fermented milk products. 4.1. Effect of EPS on the quality of yoghurts. 4.2. Effect of EPS on the quality of other fermented milk drinks. 4.3. Effect of EPS on the quality of cheeses. 5. Health-promoting properties of exopolysaccharides. 6. Conclusions
Gut Microbiota In Chronic Kidney Disease
Authors: Nalewajska Magdalena , Przybyciński Jarosław , Marchelek-Myśliwiec Małgorzata , Dziedziejko Violetta , Ciechanowski Kazimierz
Published: February 2020

In health, the relationship between gut microflora and the host is of a mutualistic kind. Microbiota offers many benefits to the host, including harvesting energy, regulating host immunity, and the synthesis of vitamins. Alteration in gut microflora can lead to homeostasis disruption and development of various diseases. Dysbiosis is commonly observed in chronic kidney disease (CKD). Nutrient processing by gut microbiota results in the production of some uremic toxins, and these accumulate in CKD causing deleterious effects. Increased permeability of the intestinal barrier, which is also seen in CKD contributes to the development of the uremic state. These factors are associated with chronic inflammation and oxidative stress and therefore are involved in CKD-related complications, including disease progression, cardiovascular disease, anemia, mineral-metabolism, and insulin resistance. This review describes connections between altered gut microflora and development of CKD and its complications, as well as possible therapeutic options.

1. Microbiota – short characteristic. 2. Mechanisms leading to alterations in gut microbiota and their effects on intestinal barrier permeability. 3. Causes of chronic kidney disease progression related to gut microbiota alterations. 4. Complications of chronic kidney disease related to gut microbiota alterations. 4.1. Cardiovascular disease. 4.2. Anemia. 4.3. Bone metabolism disorders. 4.4. Insulin resistance in CKD. 5. Therapeutic options. 6. Summary