bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Drug Management System at the Pharmacy Installation in the Hospital: a Literature Review
Authors: Mulyati Muji , Setyawan Henry , Martini Martini
Published: April 2023

ABSTRACT The hospital is an individual health service facility as well as part of the health resources that are very much needed to support the implementation of health efforts. Hospitals must change the paradigm of hospital management towards a consumer perspective, employee empowerment and service quality improvement. One of the efforts to improve the quality of hospital health services can be done by paying attention to the drug management system in pharmaceutical installations. Drug management in hospitals is an important aspect of hospital management to support quality hospital services. This study aims to determine the drug management system in hospital pharmacy installations in Indonesia. This research is a literature review by searching electronic databases published 2017-2022 and meeting the inclusion criteria. Articles were taken from Scopus, Science Direct, ProQuest, SpringerLink, Google Scholar, Nature, JSTOR, and Emerald Insight databases with a total of 18 articles used. Based on the review of the journal, the results of eighteen articles showed that there were still deficiencies in the drug management system (planning, procurement, budgeting, storage and distribution) at pharmaceutical installations in hospitals and a solution had to be found immediately to improve the drug management system. Keywords: Pharmaceutical Installations, Drug Management System, Pharmaceutical Services
Pengaruh Low Impact Aerobik terhadap Penurunan Tekanan Darah Penderita Hipertensi pada Usia Dewasa di Puskesmas Punggur Lampung Tengah 2019
Authors: Maryuni Sri , Rahman Aulia , Antoro Budi , Nurkhasanah Arini
Published: April 2023

ABSTRACT Hypertension is a chronic condition characterized by increased blood pressure on the walls of the arteries. This situation causes the heart to work harder to circulate blood throughout the body through blood vessels, even causing degenerative diseases and even death. Low impact aerobics is aerobic movement that is performed at low intensity, which can help lower blood pressure. The aim of the study was to determine the effect of low impact aerobic exercise on blood pressure in adult hypertensive patients at the Punggur Health Center, Central Lampung 2019. Type of quantitative research, pre-experimental research design with one group pretest posttest design. The number of respondents was 18 respondents. The data collection tool uses an aneroid sphygmomanometer and an observation sheet. The statistical test used is the Wilcoxon test. The results of the statistical test obtained a p-value of 0.000 (p-value <0.05), which means that there is a difference in blood pressure before and after being given low impact aerobics in adults at the Punggur Health Center, Central Lampung. This low impact aerobic exercise is a non-pharmacological treatment which can be used as an alternative to lower blood pressure in hypertension sufferers. Keywords: Low Impact Aerobics, Blood Pressure, Hypertension  ABSTRAK Hipertensi merupakan suatu keadaan kronis yang ditandai dengan meningkatnya tekanan darah pada dinding pembuluh darah arteri. Keadaan tersebut mengakibatkan jantung bekerja lebih keras untuk mengedarkan darah keseluruh tubuh melalui pembuluh darah, bahkan menyebabkan penyakit degeneratif hingga kematian. Senam aerobik low impact adalah gerakan aerobik yang dilakukan dengan intensitas rendah, yang dapat membantu menurunkan tekanan darah. Tujuan penelitian untuk mengetahui pengaruh senam low impact aerobik terhadap tekanan darah pada penderita hipertensi pada usia dewasa di Puskesmas Punggur Lampung Tengah 2019. Jenis penelitian kuantitatif, desain penelitian pre eksperiment dengan rancangan one group pretest posttest. Jumlah responden sebanyak responden. Alat pengumpulan data menggunakan spigmomanometer aneroid dan lembar observasi. Uji statistik yang digunakan yaitu uji Wilcoxon. Hasil uji satistik didapat p-value 0,000 (p-value <0,05) yang artinya ada perbedaan tekanan darah sebelum dan sesudah diberikan senam low impact aerobik pada usia dewasa di Puskesmas Punggur Lampung Tengah. Senam low impact aerobik berpengaruh sebagai pengobatan yang dilakukan secara non farmakologi dimana dapat dijadikan alternatif untuk menurunkan tekanan darah penderita hipertensi. Kata Kunci: Low Impact Aerobik, Tekanan Darah, Hipertensi
Sanjiao Heyi and Tibet
Authors: Rossow Ty
Published: April 2023

This paper considers Chinese Communist Party policies in Tibet from Confucian, Daoist, and Buddhist perspectives. I first explain how these three traditions are unified in the sanjiao heyi, but I contend that this practice has been neglected in favor of state repression. I then elucidate Confucianism, Daoism, and Buddhism with respect to their general principles and application in Tibet. I conclude that a fuller embrace of the sanjiao heyi where Confucian tenets are balanced by insights from Daoism and Buddhism would cultivate an anti-oppressive response to governmental control.
Autistic Students within the Community of Inquiry
Authors: Garwood Rylan
Published: April 2023

The standard pedagogy within Philosophy for Children courses is the community of inquiry. In this paper, I argue that the current form of the community of inquiry does not properly accommodate autistic students. Using observations from Benjamin Lukey alongside my personal testimony, I illustrate how autistic students may struggle within the community of inquiry. Importantly, I argue that this need not be the case, as the community of inquiry can be made more inclusive if it were to emphasize collaboration instead of verbal dialogue.
Language, Feminism, and Racism
Authors: Becker Cecilia , Saul Jennifer
Published: April 2023

Jennifer Saul is Waterloo Chair in Social and Political Philosophy of Language at the University of Waterloo. Originally American, she spent twenty-four years at the University of Sheffield in the United Kingdom. Her current focus is manipulative political language, which she explores in Dogwhistles and Figleaves: Linguistics Tricks for Racist and Conspiracist Discourse (forthcoming, Oxford, 2024). She has also written books and articles on feminism, lying and misleading, and implicit bias. She founded the blogs What is it Like to be a Woman in Philosophy and Feminist Philosophers, and was Director of the Society for Women in Philosophy UK 2009–19. Along with Helen Beebee, she published two reports (in 2011 and 2021) on the state of women in philosophy in the UK and drew up good practice guidelines which have been adopted by dozens of departments. She’s also proud of having been a philosophical consultant on a zombie movie.
FORMULATION OF HAIR GEL FROM CELERY ETHANOL EXTRACT (APIUM GRAVEOLENS .L)
Authors: Meinisasti Resva , Krisyanella Krisyanella , Oktasari Dewi
Published: April 2023

Background: Uncontrolled hair loss will cause baldness. Celery (Apium graveolens  L.) contains compounds apiin, apigenin, mannitol, inositol, asparagine, glutamine, choline, linamarose potassium and sodium. Apigenin is the main chemical content in celery which is known to have activity as a vasodilator that can stimulate hair growth. The purpose of the study was to determine the hair gel formula that had the best characteristics. The concentration variations used were 5%, 7.5% and 10%. This study uses experimental research methods. The activity starts from the preparation of the ethanol extract of dried celery, gel formualtion, and then evaluation of the preparation. The evaluation of the preparations included organoleptic tests, homogeneity, spreadability, pH, irritation, freeze thraw and the preference of the preparations by the respondents. The results showed that Formulas 1 (5%) and 2 (7.5%)  met the standard parameters of hair gel preparations, while formula 3 (10%) did not standardize the spreadability test. In the organoleptic test, it was seen that the higher the concentration of the extract used, the more concentrated the color of the preparation. However, the increase in extract concentration did not significantly affect the dispersion of the preparation. Based on the results obtained, it can be concluded that Formula 1 (5%) has the best hair gel preparation characteristics compared to other formulas.
PENERAPAN METODE FUZZY TSUKAMOTO PADA PERTIMBANGAN PENGANGKATAN KARYAWAN TETAP BERBASIS WEB
Authors: Nurwanda Abdi , Syah Arridha Zikra , Putra Guntur Maha
Published: April 2023

Abstract:Being a permanent employee are people who are still employees, that is a clear and guaranteed future, which gets more bonuses than contract employees. One of the national trading companies in Indonesia, namely PT Pinus Merah Abadi, also recruits employees both at the head office and at each branch of the company, but in the process decisions made for employees cannot be made by employees. branch of the company, even in the number of many who are disadvantaged because the manual is still carried out by the manager, which is then filtered by the head office. To use these things, in this study a system that supports decisions in branch offices will be made using the fuzzy tsukamoto method which is expected to work from employees. And after the support system takes this decision, employees have made successful decisions, because employees can immediately see the calculation process through the application that has been made.            Keywords: fuzzy tsukamoto; permanent employee; decision support system  Abstrak:Menjadi seorang karyawan tetap di sebuah perusahaan adalah keinginna banyak orang yang masih menjadi seorang karyawan kontrak, selain masa depan yang jelas dan terjamin, seorang karyawan tetap mendapatkan bonus yang lebih banyak dibandingkan dengan karyawan kontrak. Salah satu perusahaan dagang nasional di Indonesia yaitu PT Pinus Merah Abadi juga melakukan perekrutan untuk karyawan tetap setiap tahunnya baik di kantor pusat maupun di setiap cabang perusahaan, namun dalam prosesnya terkadang keputusan yang dibuat mengenai pengangkatan karyawan tetap oleh perusahaan  tidak memuaskan para karyawan yang ada di cabang perusahaan, bahkan terkadang para karyawan merasa dirugikan karena perhitungan nya masih dilakukan manual oleh manajer, yang kemudian diproses oleh kantor pusat. Untuk menangani hal tersebut, dalam penelitian ini akan dibuat sebuah sistem pendukung keputusan di kantor cabang perusahaan khususnya kantor cabang kisaran menggunakan metode fuzzy tsukamoto yang diharapkan bisa menangani keluhan dari para karyawan. Dan setelah sistem pendukung keputusan ini digunakan, para karyawan cabang sudah bisa menerima keputusan yang telah dibuat manajer, karena karyawan bisa langsung melihat proses perhitungannya melalui apikasi yang sudah dibuat. Kata kunci: fuzzy tsukamoto; karyawan tetap; sistem pengambilan keputusan
TOPICAL ISSUES OF IMPROVING COMBAT CAPABILITIES OF MILITARY INTELLIGENCE UNITS
Authors:   Military Academy (Odesa), Zaitsev I. , Babak V. ,   Military Academy (Odesa), Moshchenko D. ,   Military Academy (Odesa)
Published: April 2023

Threats to the independence, sovereignty and territorial integrity of Ukraine, especially the ongoing aggression of the Russian Federation, high dynamism of combat operations in modern combined arms combat, rapid changes in circumstances, rapid transition from one type of action to another, limited time to perform assigned combat tasks, complex tactical environment, large availability and saturation of new modern military various armored combat vehicles and weapons with different tactical and technical characteristics, have expanded and made more complex the work of the obtaining and acquiring intelligence about the enemy. The available military equipment used by the ground forces of the Russian Armed Forces shows that tanks and armored combat vehicles remain their main models. They are characterized by increased cross-country ability, maneuverability, ability to move in any season, fire at night and over long distances, overcome water obstacles, have increased protection, a fire control system, powerful weapons, the ability to transport troops, the necessary autonomy to perform certain tasks, etc. The military intelligence units solve complex intelligence tasks, which are achieved by its early organization, directing the efforts of all types of intelligence to the most important tasks, determining intelligence by the established deadline, thoroughly studying, comparing and further verifying it, and, if necessary, conducting additional intelligence, highly trained personnel, as well as using the most advanced intelligence methods and means. All of this requires the widespread introduction of new technical intelligence means into the troops. And the complexity of solving intelligence tasks, the need for effective use of technical intelligence means, in turn, requires highly professional skills of intelligence officers. The problems of equipping units of the Armed Forces and other military formations of the security and defense sector are caused by the fact that a significant number of available weapons and military equipment have long service lives, are morally and physically outdated and require appropriate modernization or replacement with new models. Based on the analysis of the characteristics and trends in the development of modern models of anti-tank missile systems, taking into account the practical experience gained by the troops during the Joint Forces Operation and combat operations to repel armed aggression, the article considers the problematic issues of increasing the combat capabilities of military intelligence units.
THEORETICAL AND METHODOLOGICAL BASIS OF THE CRISIS SITUATIONS THREATENING THE NATIONAL SECURITY OF UKRAINE
Authors:   Institute for training legal personnel for the SBU of the National University of Law named after Yaroslav the Wise, Yevtushenko I.
Published: April 2023

It has been established that at today's stage of development of the democratic Ukrainian society, security issues come to the fore. Mechanisms for responding to crisis situations occupy a special place in the state's national security system. The appropriate level of provision of the state and the population against the threat of crisis situations that threaten national security is a guarantee of sustainable development of society, and this proves the relevance of the chosen research topic. The purpose of the article is the scientific substantiation of the theoretical and methodological foundations of the phenomenon of crisis situations that threaten national security and the provision of practical recommendations for further improvement and development of appropriate response mechanisms of the components of the security and defense sector of Ukraine. It was determined that modern conflicts require a comprehensive solution, as well as the participation of various departments, power structures and organizations in ensuring the safety of citizens, protecting the constitutional system, sovereignty and territorial integrity of the state, in eliminating grave consequences, etc. Under such conditions, the security forces of the security and defense sector of Ukraine play an important role. Today, global globalization processes contribute to the emergence and aggravation of armed conflicts of various levels of intensity. Therefore, the modern theory of international law includes international organizations (UN, NATO, etc.) as possible subjects of international armed conflicts. In addition, recent events in the world clearly show the growth of terrorist attacks, and later military conflicts, based on the processes of globalization. Analyzing the normative legal documents that regulate the defining principles of the functioning of the national security system, it was established that a new term "crisis situations that threaten the national security of Ukraine" was introduced, which characterizes the situation on the eve of the introduction of a special period. These terms are also used in the terminological apparatus used during the response of the components of the security and defense sector to threats to the national security of Ukraine. A key point during the emergence of crisis situations is the introduction of appropriate response mechanisms that require the involvement of additional forces and resources. It was determined that in further scientific research it is necessary to substantiate the proposals for solving the scientific problem regarding the functioning and development of mechanisms for responding to crisis situations that threaten the national security of Ukraine.
MATHEMATICAL MODEL OF THE OPTICAL-MECHANICAL SENSOR FOR MEASURING OF GEOMETRIC CHARACTERISTICS OF FIREARMS BORES
Authors:   The National academy of hte National Guard of Ukraine, Kriukov O. , Migura O. ,   The National academy of hte National Guard of Ukraine
Published: April 2023

The work is devoted to the study of the characteristics of the optical-mechanical sensor for the measurement control of geometric characteristics of firearms bores. The results of the analysis of publications devoted to the structure and application of measuring devices based on the triangulation method of distances determining are given. The limited possibility of applying of the results obtained in known works in the creation of an optical-mechanical sensor for diagnosing of firearms bores was noted. Features of construction and basic geometric parameters of the optical-mechanical sensor are considered. A description of the measurement method is given, which provides for the calculation of the desired distance using the known parameters of the optical scheme of the optical-mechanical sensor and the linear and angular parameters of the triangles consisting of the elements of the optical scheme of the sensor. An expression for the dependence of the angle between the optical axis of the receiving lens and the light-sensitive detector from other basic geometric parameters of the optical-mechanical sensor was obtained using the basic formula for a thin lens. The expression determines the angular position of the light-sensitive detector in relation to the main optical axis of the receiving lens and should be taken into account as a limitation in the practical implementation of the sensor. The conversion function of the optical-mechanical sensor is determined, which establishes the dependence between the increment of the coordinate of the light spot on the surface of the light-sensitive detector of the sensor and the increment of the radius of the bore. An expression for solving the inverse problem � calculating the value of the input value based on measurement information about the output value � was obtained. Graphs of these functions for typical combinations of optical-mechanical sensor parameters are given. A study of the linearity of the conversion function of the optical-mechanical sensor and the nature of its sensitivity change within the range of measurement was conducted.
STRUCTURED INTERVIEW WITH MILITARY OFFICERS WHO PARTICIPATED IN COMBAT ACTIONS WITH SIGNS OF MORAL TRAUMA
Authors:   The National academy of hte National Guard of Ukraine, Matsegora Ya. , Kolesnychenko O. ,   The National academy of hte National Guard of Ukraine
Published: April 2023

Soldiers at war are required to make the most important, intense, and difficult moral decisions of their lives. However, not every serviceman is able to carry out these decisions. As a result, many combatants suffer from lasting shame, anger, alienation, loss of religious beliefs, and other effects that are now called moral trauma. Available scientific approaches to understanding moral trauma and restoring the mental health of servicemen who were participants in morally traumatic events are summarized. An algorithm for conducting a structured interview has been developed, which involves the following stages: notation and reconstruction of the event, description of experiences, experiences and thoughts; determination of remote consequences of the event and prospects for the development of changes in himself, which the serviceman himself sees; determination of resources; searching for a basis for self-healing. At various stages of recovery of mental health, a serviceman not only finds the meaning of the suffering experienced, but also realizes how to use his own experience based on his psychological knowledge in the future, learns techniques (breathing, neurolinguistic programming, etc.) to overcome the negative symptoms of moral trauma and post-traumatic stress stress disorder. They achieve an understanding of the existing connection between the event and the destruction itself, form an idea of the normality of one's own imperfection and the need to forgive oneself or atone for guilt in a constructive way. It was determined that the proposed structured interview essentially serves as a step-by-step instruction for psychologists when conducting measures to restore and preserve the mental health of military personnel participating in hostilities.
HISTORICAL AND LEGAL FOUNDATIONS OF THE IMPLEMENTATION OF THE LEND-LEASE PROGRAM IN 1941?1945 AND MODERN PROSPECTS OF LEND-LEASE FOR UKRAINE
Authors:   Ivan Chernyakhovsky National University of Defense of Ukraine, Fedchuk T. , Bidnyi V. ,   Military History Research Center of the Armed Forces of Ukraine, Tichna B. ,   Department of Legal Support of the Ministry of Defense of Ukraine, Mogilevska V. ,   Ivan Chernyakhovsky National University of Defense of Ukraine
Published: April 2023

The Russian-Ukrainian war, which began in February 2014 with the aggression of the Russian Federation against Ukraine, opened a new page in the history of our country. In February 2022, Russian troops launched a large-scale invasion of the territory of Ukraine, but encountered a resolute repulse from the Defense Forces of Ukraine. However, as the scale of hostilities increased, so did the need for help from Western democratic states to Ukraine. The article is devoted to conducting a retrospective analysis of the historical and legal foundations of the implementation of the lend-lease program during the Second World War and promising ways of its application in Ukraine in today's conditions. During the retrospective analysis, it was determined that the supply of lend-lease made it possible to solve the main problematic issues of the Soviet economy, namely the production of gasoline, explosives, aluminum, other non-ferrous metals, radio stations, trucks, etc. The significance of the military aid provided under the Lend-Lease Act of 1941, which was crucial for strengthening the potential of US allied states in armed confrontation with Hitler's coalition states, is established. The role of the decision on the introduction of lend-lease for Ukraine by the United States is given in terms of the role of Ukraine in restraining Russian armed aggression and preventing its spread to the west, in particular to the states of NATO's eastern flank. At the same time, it is proposed to consider that lend-lease for Ukraine is the receipt by our state of strategically important military aid for the further effective repulsion of the aggression of the armed forces of the Russian Federation in view of the risks of prolonging the military conflict. Today, a similar step is a powerful help in strengthening Ukraine's defense capabilities and resisting Russia's armed aggression, which improves the prospects for the liberation of temporarily occupied Ukrainian territories. It has been established that Lend-Lease will not only be a guarantee of our victory on the battlefield, but will also stimulate the development of the defense industry of our country, and therefore will become a powerful catalyst for the development of the Ukrainian economy.
Saúde e qualidade de vida: os impactos da Covid-19 na agricultura familiar
Authors: Costa Kylvia Luciana Pereira , Adriano Maria Soraya Pereira Franco , Leite Michael Douglas Sousa , Queiroga Jailson Batista , Sátyro Marcos Andrei da Silva Alves , Medeiros Ênnio Karlos Muniz de , Santos Kaio Luís de Azevêdo , Silva Aline Cristina de Araújo Florentino , Sousa Marilene Izidoro de , Sousa Katiane Pires Queiroga Gomes de , Nóbrega Mário Gustavo Lúcio Albuquerque da , Lira Felipe Dantas de , Cavalcanti Maria do Socorro Ferreira de Oliveira , Sousa Izairane Dutra de
Published: April 2023

Este artigo teve como objetivo analisar os impactos da Covid-19 na saúde e qualidade de vida dos agricultores e produtores familiares no Brasil. O método que foi utilizado foi uma revisão bibliográfica. Para a busca dos trabalhos foi usado descritores de maneira a abranger aspectos relacionados às dimensões saúde e modo de vida relacionadas aos pequenos produtores e agricultores. Na questão da saúde e modo de vida, os impactos versam sobre a dificuldade de atender a população rural. Questões climáticas e geográficas, como o período chuvoso na Amazônia, prejudicaram transporte fluvial e o trânsito terrestre, dificultando assim a circulação dos profissionais, usuários, e dos insumos trazendo inúmeros desafios ao acesso aos serviços. Verificou-se que a pandemia reforçou as situações de vulnerabilidade social e os quadros de desigualdade e exclusão dos agricultores e produtores da agricultura familiar, além disso a pandemia trouxe quadros de instabilidade emocional gerando desconforto, conflitos e questionamentos. A pandemia exacerbou nossas deficiências estruturais na questão sanitária, desafiando nossa capacidade de conter a contaminação da Covid-19. A mensagem da ONU é clara: água, saneamento e higiene são essenciais na mitigação e no enfrentamento do vírus. Trata-se de uma reconstrução do direito à saúde por meio da oferta e disponibilidade da água e saneamento adequados que respeitem, protejam e cumpram aspectos do direito à água, como meio de resguardar a saúde, como direito fundamental e de dignidade humana.
Estudo comparativo entre a autopercepção das características cutâneas e o formulário Baumann
Authors: Souza Camilla Radimack Santos de , Fontes Rafael Barros , Godoy Charles Antônio Pires de
Published: April 2023

O presente estudo teve por objetivo observar e entender o autoconhecimento da população selecionada no que tange os tipos de pele apresentadas por moradores do estado de Sergipe, dentro da faixa etária de 20 a 60 anos de idade, de ambos os sexos e diversas etnias. Para isto, aplicou-se aos voluntários o questionário de Baumann, desenvolvido pela dermatologista Leslie Baumann nos EUA e composto de 64 perguntas que classificam a pele em relação à hidratação, à sensibilidade, à pigmentação e à tendência a rugas.  Os resultados obtidos, inicialmente, mostram que há predominância, entre os avaliados, de pessoas com pele com sensibilidade aumentada, grande quantidade de sebo, com baixo nível de pigmentação e com tendência a rugas. Considerando a alta miscigenação no estado de Sergipe, em decorrência do período colonial, e das características da maior parte da população avaliada, o presente estudo evidencia a importância dos cuidados gerais para esta população.
2,5(6)-DİSÜBSTİTÜEBENZİMİDAZOL TÜREVİ LİGANDLARI TAŞIYAN PLATİN KOMPLEKSLERİNİN SENTEZİ VE ANTİKANSER AKTİVİTELERİNİN ARAŞTIRILMASI
Authors: ALJENDY Yasmin , ORUÇ DEMİRBAĞ Hatice , BAYRAM Gül , UTKU Semra
Published: April 2023

Amaç: Sisplatin, klinikte kanser hastalarının tedavisinde başarılı bir şekilde kullanılmasına rağmen hastalarda rezistans gelişimi ve ciddi toksik yan etkiler görülmektedir. Bu dezavantajların önüne geçmek için bu çalışmada 2,5(6)-disübstitüebenzimidazol türevi taşıyıcı ligandlar kullanarak platin(II) komplekslerinin sentezlenmesi ve sitotoksik etkilerinin test edilmesi amaçlanmıştır.

Gereç ve Yöntem: L1-L6 taşıyıcı ligandları Philips yöntemine göre elde edilmiştir. K1-K4 kompleksleri, K2PtCl4 ve uygun ligandın ısıtılıp karıştırılması ile sentezlenmiştir. Sentez edilen L1-L6 ve K1-K4’ün kimyasal yapıları elementel analiz, İnfrared ve 1H Nükleer Manyetik Rezonans ile aydınlatılmıştır. L1-L6 taşıyıcı ligandları ve K1-K4 komplesklerinin, MTT yöntemi ile MCF-7 ve DU-145 hücre hatlarına karşı in vitro sitotoksik etkileri test edilmiştir.

Sonuç ve Tartışma IC50 değerlerine göre 2 numaralı konumunda –CH3 sübstitüenti taşıyan ligandlar, nonsübstitüe ligandlara göre test edilen hücre hatlarında daha etkili bulunmuştur. Ayrıca 5(6) numaralı konumunda flor sübstitüe L5 ve L6 en etkili benzimidazol türevi olarak test edilmiştir. Test edilen kompleksler içerisinde K3, MCF-7 hücre hattına karşı 32.75 µM IC50 değeri ile DU-145 hücre hattında ise 18.842 µM IC50 değeri ile en etkili kompleks olarak bulunmuştur.
An Exploratory Study on the Festive Meaning of Marathon Event Participants
Authors:   The Korean Society of Culture and Convergence, Yu Youngseol
Published: April 2023

The purpose of this paper is to explore the meaning of festival to the participants in marathon events using Q methodology. This Q factor analysis finally identified 3 factors: The first factor, The Community Consciousness Enjoyment, through the process of sharing and enjoying common hobbies, encouraging and cheering each other, they feel the meaning of sympathy for friendship and homogeneity that overcomes difficulties. The second factor, The Overcoming the Limitations of the Mind and Body, They feel catharsis through accomplishment and achieving their goal through the process of fighting with themselves. The final factor, The Escape from Everyday Life, They are recognized as a different experience that is difficult to encounter in everyday life, such as getting out of daily life, going though the training process of patience, getting support and encouragement from each other.
A Study on the Relationship between Agency and Adaptation to College Among Chinese International Students: The Moderated Mediating Effect of Acculturative Stress and Korean Language Proficiency
Authors:   The Korean Society of Culture and Convergence, Liu Lulu , Kim Jungsub , Kim Eunji , Kee Heekyung , Jin Wenjing
Published: April 2023

The purpose of this study was to identify the relationship between agency, acculturative stress, adaptation to college and Korean language proficiency among Chinese international students. For this study, online survey was conducted on 263 Chinese international students. The main results are as follows. First, agency directly affects adaptation to college. Second, acculturative stress partially mediated the relationship between agency and adaptation to college. Third, Korean language proficiency moderated the mediating effect of acculturative stress in the relationship between agency and adaptation to college. Based on the results, related suggestions were proposed to help Chinese international students better adapt to their college life in Korea.
The Mediating Effect of Resilience in the Relationship between Depression and Academic Burnout in Female College Students
Authors:   The Korean Society of Culture and Convergence, Kang Yunsin , Choi Boyoung
Published: April 2023

The purpose of this study was to verify the mediating effect of resilience in the relationship between depression and academic burnout perceived by female college students. A survey was conducted on female college students in the metropolitan area and non-metropolitan areas on depression, academic burnout, and resilience, and 178 copies of the collected data were analyzed. The results of correlation analysis and hierarchical regression analysis using SPSS 18.0 are as follows. First, there was a positive correlation between depression and academic burnout, a negative correlation between depression and resilience, and a negative correlation between resilience and academic burnout. Second, resilience showed a complete mediating effect in the relationship between depression perceived by female college students and academic burnout. The significance of the results of this study is that it provided basic data to present the direction and contents of guidance or counseling programs to effectively deal with academic burnout of college students.
Types of Existence and Cultural Implications of the Spiritual Altar in the Ancient Period of Northeast Asia
Authors:   The Korean Society of Culture and Convergence, Park Sunsik
Published: April 2023

This paper examines the type of existence and its cultural significance of the sacred monument that existed during the ancient period of Northeast Asia. The largest new altar type was the Hongsan ruins of Inner Mongolia, which consists of altars, shrines, and tombs, and the Ganghwa Chamseongdan on the Korean Peninsula. In the case of the Hongsan area, an aspect reflecting the political intention of highlighting strong sacredness was read. In the case of the Chamseongdan, it also suggested an inference that it expressed a sacred uterus that conceived life, reflecting the sacred consciousness of repaying the root. Subsequently, as a second-highest type of new foundation, Daegok-ri Petroglyphs in Ulsan and Cheonjeon-ri Petroglyphs in Korea suggested a differentiated, exclusive, selective sacred space and an open and open sacred space. In addition, dolmens and menhir were examined in the small and medium-sized construction type, and the ceremonial scenes carved on the side walls were examined. As for other types of movable variable, we looked at the bronze altar of the Samseongtoe Ruins, which is drawing attention as an archaeological survey, and paid attention to the symbolism of the new animal.
Solar System Wave Packet
Authors: Soltani Abolfazl
Published: April 2023

If Titius-Bode Law (TBL) was only a relation between three, four or even five planets, then we could call it a coincidence, but when it is true for seven planets, plus Ceres and Pluto (nine objects), there is definitely a reason for it. Here, we show that, probably, the existence of a standing and cosine wave packet in solar system, with the wavelength λ = 0.6 AU (AU represents the distance of Earth from the sun) and the phase constant ∅0=π/6, is the reason for TBL. In this article we obtain the equation of this wave packet. In this article we prove that without Solar System Wave Packet (SSWP), it is not possible to reach to the TBL from the protoplanetary disk of solar system. Here we show that the nebular theory (or nebular hypothesis) without SSWP theory is an incomplete theory.
Indoor heat stress mitigation in low-income Kenyan homes with mosquito prevention intervention
Authors: Bardhan Ronita , Li Haiwei , Abong’o Bernard , Raman Haima , Zhao Yongling
Published: April 2023

With rapid urbanization and massive low-income housing construction, Kenya is under severe risks of indoor and outdoor overheating, which is commonly seen as an accelerator of transmission and geographical expansion of vector-borne diseases, such as malaria. This study uses computational fluid dynamic (CFD) simulation to investigate the indoor heat stress of a typical low-income house with and without mosquito prevention technology in Siaya county in western Kenya. The intention is to propose optimal and applicable heat mitigation solutions, including ceiling insulation, white roof coating, and cross-ventilation for low-income housing with the consideration of mosquito prevention. Results show that houses with mosquito prevention interventions have the potential to reduce heat stress, provided the design of the houses is taken into consideration. The sustainable, resilient, and inexpensive design with retrofitting solutions can benefit policymakers in reducing heat-health burdens while reducing the incidence of vector-borne diseases in the low-income houses of Africa.
From Compact Discs to Streaming: A Comparison of Eras within the Brazilian Market
Authors: Seufitelli Danilo B. , Oliveira Gabriel P. , Silva Mariana O. , Barbosa Gabriel R. G. , Melo Bruna C. , Botelho Juliana E. , Melo-Gomes Luiza de , Moro Mirella M.
Published: April 2023

The music industry has undergone many changes in the last few decades, notably since vinyl, cassettes and compact discs faded away as streaming platforms took the world by storm. This Digital evolution has made huge volumes of data about music consumption available. Based on such data, we perform cross-era comparisons between Physical and Digital media within the music market in Brazil. First, we build artists' success time series to detect and characterize hot streak periods, defined as high-impact bursts that occur in sequence, in both eras. Then, we identify groups of artists with distinct success levels by applying a cluster analysis based on hot streaks' features. We find the same clusters for both Physical and Digital eras: Spike Hit Artists, Big Hit Artists, and Top Hit Artists. Our results reveal significant changes in the music industry dynamics over the years by identifying the core of each era.
Real-time Analysis of Interactive Scores in PWGL
Authors: Kuuskankare Mika
Published: April 2023

In this article, we introduce an original approach to computerized music analysis within the graphical computer-assisted composition environment called PWGL. Our aim is to facilitate real-time analysis of interactive scores written in common Western music notation. To this end, we have developed a novel library that allows us to analyze scores realized with the help of ENP, and to visualize the results of the analysis in real-time. ENP is the native music notation tool of PWGL able to produce automatically typeset and interactive music notation. Here, it is extended to support the display of analytical information that can be drawn on top of the score as an overlay. The analysis backend is realized with the help of our built-in musical scripting language. The language is based on pattern-matching and allows for a rich access of score information. The results of the analysis are presented directly as a part of the original score leveraging the extensible and interactive visualization capabilities of ENP.
Schaeffer's Solfège, Percussion, Audio Descriptors: Towards an Interactive Musical System
Authors: Freire Sérgio , Padovani José Henrique , Campos Caio Costa
Published: April 2023

Pierre Schaeffer's typomorphology (1966) proposes seven criteria of musical perception for the identification and qualification of sound objects, which form the basis of his musical theory. This Solfège fits well into contexts where pitch is not the dominant dimension. Relying on similarities between the practice of reduced listening and the utilization of low-level audio descriptors, we present the first version of a real-time setup in which these descriptors are applied to qualify percussive sounds. The paper describes the tools and strategies used for addressing different criteria: envelope followers with different window sizes and filtering; detection of transients and amplitude modulations; extraction and counting of spectral components; estimation of intrinsic dissonance and spectral distribution; among others. The extracted data is subjected to simple statistical analysis, producing scalar values associated with each segmented object. Finally, we present a variety of examples.
Pesquisa em composição e análise: Ferramentas computacionais, inter-relações e emergências
Authors: Rossetti Danilo
Published: April 2023

Nos séculos XX e XXI o suporte computacional promoveu inter-relações entre as áreas de composição e análise musical de forma singular. Dentro do contexto acadêmico, a relação entre estas duas áreas pode se dar por meio de proposições de hipóteses analíticas cujos resultados de análise que são utilizados em novas criações. Neste artigo, colocamos a questão se estas áreas podem configurar um sistema que se retroalimenta e se transforma constantemente a partir das novas informações obtidas no decorrer dos processos. Propomos a análise da obra Substâncias moldáveis – versão 2 que apresenta uma segmentação formal em duas partes com características sonoras distintas. Para a análise de cada parte, adotamos ferramentas de análise específicas considerando a hipótese de que as ferramentas empregadas devem se adaptar às características da obra. Como análise dos resultados, integramos duas partes gerando representações gráficas comparativas de características acústicas e psicoacústicas analisadas. Por fim, como conclusão, fornecemos uma interpretação dos fenômenos emergentes das massas e texturas sonoras presentes na obra a partir das representações gráficas criadas.
Research progress on perioperative blood-brain barrier damage and its potential mechanism
Authors: Qiu Yong , Mo Chunheng , Xu Shiyu , Chen Lu , Ye Wanlin , Kang Yi , Chen Guo , Zhu Tao
Published: April 2023

The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins. During the perioperative period, anesthesia and surgical operations are also a kind of stress to the body, which may be accompanied by blood-brain barrier damage and brain metabolism dysfunction. Perioperative blood-brain barrier destruction is closely associated with cognitive impairment and may increase the risk of postoperative mortality, which is not conducive to enhanced recovery after surgery. However, the potential pathophysiological process and specific mechanism of blood-brain barrier damage during the perioperative period have not been fully elucidated. Changes in blood-brain barrier permeability, inflammation and neuroinflammation, oxidative stress, ferroptosis, and intestinal dysbiosis may be involved in blood-brain barrier damage. We aim to review the research progress of perioperative blood-brain barrier damage and its potential adverse effects and potential molecular mechanisms, and provide ideas for the study of homeostasis maintenance of brain function and precision anesthesia.
Revising the effectiveness of municipal waste management in Hong Kong
Authors: Ma Fong Ching , Wong Tsan Lok , Chan Chun Ngai , Ran Lishan
Published: April 2023

Although there have been many studies related to the municipal solid waste (MSW) problem in Hong Kong, only limited research has recently discussed the spatial variation of citizens’ environmental awareness in different geographical constituencies. Also, the relationship between environmental awareness of citizens and the effectiveness of waste management has been poorly understood. This research aims to evaluate the effectiveness of three proposed approaches; investigate whether the environmental awareness of citizens will affect the effectiveness of current waste management strategies; and examine the differences in the level of environmental awareness of residents in different geographical constituencies, so we can provide suggestions to help mitigate the solid waste problem. In addition, the hypothesis is that there is a relationship between environmental awareness of citizens and its effectiveness. This research adopted quantitative observations and questionnaires as well as qualitative interviews to understand the public perception about the proposed MSW charging, plastic shopping bag charging and recycling in Hong Kong. This research confirmed that the environmental awareness of Hong Kong citizens varies among various geographical constituencies. Residents in Kowloon West have comparatively lower environmental awareness may due largely to the socio-economic background of residents and comparatively unhygienic environment, and they often do not support plastic shopping bag charging and recycling. In addition, males have a lower environmental awareness than females as their attitude towards charging policy may not have much impact on their lifestyle. It is not surprising that low environmental awareness of citizens will reduce the effectiveness of current environmental policies. MSW charging tends to be effective and should be implemented in Hong Kong. Furthermore, plastic shopping bag charging can be effective in the short term but ineffective in the long term, and recycling tends to be invalid as Hong Kong has not developed a circular economy. The limitations of each policy should be considered, and more studies are needed to improve the existing policies as well as exploring novel ways to solve the MSW problem.
Drivers for ecosystem respiration during the drawdown period in Dongting Lake, China
Authors: Zhou Yan , Jing Lei , Wang Shaoquan , Jia Yifei , Wang Yushu , Lei Guangchun
Published: April 2023

Global lakes play an active role in releasing carbon into the atmosphere. However, previous research was less focused on shallow tropical and sub-tropical lakes, especially ecosystem respiration during the drawdown period. This study was designed to determine the environmental factors that determine ecosystem respiration during the drawdown period in a typical shallow sub-tropical lake, Dongting Lake in China. Ecosystem respiration from the exposed mudflat and a newly colonized meadow were investigated using a Li-8100 soil CO2 flux system in situ. The soil water content soil organic carbon (SOC), dissolved organic carbon (DOC), total nitrogen and soil C/N ratio were measured at 0–30 cm soil depth layers. No difference was found among different soil depth layers for soil properties, while the dissolved organic carbon value varied significantly among different levels of the cumulative days of the mudflat exposed to the air (CDE). Carex colonizing significantly increased soil organic carbon and DOC at the surface soil layer. Exposure to the air and Carex colonizing together strengthened the intensity of carbon dioxide (CO2) emission in the mudflat, achieving 0.716 ± 0.114 μmol m-2s-1 and 2.240 ± 0.375 μmol m-2s-1, respectively. Exposure to the air led mudflat to exceed other landscapes or different vegetation types in Dongting Lake, becoming the most active area releasing CO2 into the atmosphere, with the respiration flux reaching a peak period at around 60 days after exposure, which was enormously reinforced by Carex colonizing. Reducing the area and duration of mudflat exposure to the air during the drawdown period might be useful in reducing CO2 emissions to the atmosphere in shallow sub-tropical lakes.
Comparative molecular dynamics simulations of pathogenic and non-pathogenic huntingtin protein monomers and dimers
Authors: Khaled Mohammed , Strodel Birgit , Sayyed-Ahmad Abdallah
Published: April 2023

Polyglutamine expansion at the N-terminus of the huntingtin protein exon 1 (Htt-ex1) is closely associated with a number of neurodegenerative diseases, which result from the aggregation of the increased polyQ repeat. However, the underlying structures and aggregation mechanism are still poorly understood. We performed microsecond-long all-atom molecular dynamics simulations to study the folding and dimerization of Htt-ex1 (about 100 residues) with non-pathogenic and pathogenic polyQ lengths, and uncovered substantial differences. The non-pathogenic monomer adopts a long α-helix that includes most of the polyQ residues, which forms the interaction interface for dimerization, and a PPII-turn-PPII motif in the proline-rich region. In the pathogenic monomer, the polyQ region is disordered, leading to compact structures with many intra-protein interactions and the formation of short β-sheets. Dimerization can proceed via different modes, where those involving the N-terminal headpiece bury more hydrophobic residues and are thus more stable. Moreover, in the pathogenic Htt-ex1 dimers the proline-rich region interacts with the polyQ region, which slows the formation of β-sheets.