bluuebunny/crossref_metadata_2025 huggingface dataset:
The plasminogen protein is associated with high myopia as revealed by the iTRAQ-based proteomic analysis of the aqueous humor
Authors: Wen Kai , Shao Xianfeng , Li Yahong , Li Yaoling , Li Yongtao , Wang Qing , Su Ruihong , Zhang Lujie , Cai Yang , Sun Jing , Zhang Yan
Published: April 2021

To explore the pathogenesis of high myopia (HM) using quantitative proteomics. The aqueous humor of patients with simple nuclear cataract and nuclear cataract complicated with HM (hereinafter referred to as “C” and “HM” groups, respectively) were collected. The isobaric tags for relative and absolute quantitation (iTRAQ)-based liquid chromatography–tandem mass spectrometry (LC–MS/MS) proteomics approach was employed to explore differentially expressed proteins (DEPs). Bioinformatics was used to interpret the proteomic results. Furthermore, the plasminogen (PLG) protein was confirmed by enzyme-linked immunosorbent assay (ELISA) as the candidate biomarker for HM through a receiver operating characteristic curve analysis. The study showed 32 upregulated and 26 downregulated proteins. The gene ontology analysis demonstrated that 58 DEPs corresponded to 325 biological processes, 33 cell components, and 45 molecular functional annotations. The Kyoto Encyclopedia of Genes and Genomes analysis showed that the upregulated DEPs were highly enriched in the coagulation and complement cascades, consistent with the gene set enrichment analysis. Our data suggested that some DEPs might be hallmarks of the development of HM. ELISA confirmed that the PLG expression levels were significantly upregulated in HM. This was a new study investigating alterations in protein levels and affected pathways in HM using iTRAQ-based quantitative proteomics. Our study provided a comprehensive dataset on overall protein changes and shed light on its potential molecular mechanism in human HM.
A high-resolution assessment of climate change impact on water footprints of cereal production in India
Authors: Mali Santosh S. , Shirsath Paresh B. , Islam Adlul
Published: April 2021

Water footprint (WF), a comprehensive indicator of water resources appropriation, has evolved as an efficient tool to improve the management and sustainability of water resources. This study quantifies the blue and green WF of major cereals crops in India using high resolution soil and climatic datasets. A comprehensive modelling framework, consisting of Evapotranspiration based Irrigation Requirement (ETIR) tool, was developed for WF assessment. For assessing climate change impact on WF, multi-model ensemble climate change scenarios were generated using the hybrid-delta ensemble method for RCP4.5 and RCP6.0 and future period of 2030s and 2050s. The total WF of the cereal crops are projected to change in the range of − 3.2 to 6.3% under different RCPs in future periods. Although, the national level green and blue WF is projected to change marginally, distinct trends were observed for Kharif (rainy season—June to September) and rabi (winter season—October to February) crops. The blue WF of paddy is likely to decrease by 9.6%, while for wheat it may increase by 4.4% under RCP4.5 during 2050s. The green WF of rabi crops viz. wheat and maize is likely to increase in the range of 20.0 to 24.1% and 9.9 to 16.2%, respectively. This study provides insights into the influences of climate change on future water footprints of crop production and puts forth regional strategies for future water resource management. In view of future variability in the WFs, a water footprint-based optimization for relocation of crop cultivation areas with the aim of minimising the blue water use would be possible management alternative.
Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progression
Authors: Fang Wei Bin , Sofia Acevedo Diana , Smart Curtis , Zinda Brandon , Alissa Nadia , Warren Kyle , Fraga Garth , Huang Li-Ching , Shyr Yu , Li Wei , Xie Lu , Staggs Vincent , Hong Yan , Behbod Fariba , Cheng Nikki
Published: April 2021

Ductal carcinoma in situ (DCIS) is the most common type of pre-invasive breast cancer diagnosed in women. Because the majority of DCIS cases are unlikely to progress to invasive breast cancer, many women are over-treated for DCIS. By understanding the molecular basis of early stage breast cancer progression, we may identify better prognostic factors and design treatments tailored specifically to the predicted outcome of DCIS. Chemokines are small soluble molecules with complex roles in inflammation and cancer progression. Previously, we demonstrated that CCL2/CCR2 chemokine signaling in breast cancer cell lines regulated growth and invasion through p42/44MAPK and SMAD3 dependent mechanisms. Here, we sought to determine the clinical and functional relevance of CCL2/CCR2 signaling proteins to DCIS progression. Through immunostaining analysis of DCIS and IDC tissues, we show that expression of CCL2, CCR2, phospho-SMAD3 and phospho-p42/44MAPK correlate with IDC. Using PDX models and an immortalized hDCIS.01 breast epithelial cell line, we show that breast epithelial cells with high CCR2 and high CCL2 levels form invasive breast lesions that express phospho-SMAD3 and phospho-p42/44MAPK. These studies demonstrate that increased CCL2/CCR2 signaling in breast tissues is associated with DCIS progression, and could be a signature to predict the likelihood of DCIS progression to IDC.
Support vector regression-based QSAR models for prediction of antioxidant activity of phenolic compounds
Authors: Shi Ying
Published: April 2021

The Support vector regression (SVR) was used to investigate quantitative structure–activity relationships (QSAR) of 75 phenolic compounds with Trolox-equivalent antioxidant capacity (TEAC). Geometric structures were optimized at the EF level of the MOPAC software program. Using Pearson correlation coefficient analysis, four molecular descriptors [n(OH), Cosmo Area (CA), Core-Core Repulsion (CCR) and Final Heat of Formation (FHF)] were selected as independent variables. The QSAR model was developed from the training set consisting of 57 compounds and then used the leave-one-out cross-validation (LOOCV) correlation coefficient to evaluate the prediction ability of the QSAR model. Used Artificial neural network (ANN) and multiple linear regression (MLR) for comparing. The RMSE (root mean square error) values of LOOCV in SVR, ANN and MLR models were 0.44, 0.46 and 0.54. The RMSE values of prediction of external 18 compounds were 0.41, 0.39 and 0.54 for SVR, ANN and MLR models, respectively. The obtained result indicated that the SVR models exhibited excellent predicting performance and competent for predicting the TEAC of phenolic compounds.
Author Correction: Comparison of eight complete chloroplast genomes of the endangered Aquilaria tree species (Thymelaeaceae) and their phylogenetic relationships
Authors: Hishamuddin Muhammad Syahmi , Lee Shiou Yih , Ng Wei Lun , Ramlee Shairul Izan , Lamasudin Dhilia Udie , Mohamed Rozi
Published: April 2021

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Quantitative real-time analysis of the efflux by the MacAB-TolC tripartite efflux pump clarifies the role of ATP hydrolysis within mechanotransmission mechanism
Authors: Souabni Hager , Batista dos Santos William , Cece Quentin , Catoire Laurent J. , Puvanendran Dhenesh , Bavro Vassiliy N. , Picard Martin
Published: April 2021

Tripartite efflux pumps built around ATP-binding cassette (ABC) transporters are membrane protein machineries that perform vectorial export of a large variety of drugs and virulence factors from Gram negative bacteria, using ATP-hydrolysis as energy source. Determining the number of ATP molecules consumed per transport cycle is essential to understanding the efficiency of substrate transport. Using a reconstituted pump in a membrane mimic environment, we show that MacAB-TolC from Escherichia coli couples substrate transport to ATP-hydrolysis with high efficiency. Contrary to the predictions of the currently prevailing “molecular bellows” model of MacB-operation, which assigns the power stroke to the ATP-binding by the nucleotide binding domains of the transporter, by utilizing a novel assay, we report clear synchronization of the substrate transfer with ATP-hydrolysis, suggesting that at least some of the power stroke for the substrate efflux is provided by ATP-hydrolysis. Our findings narrow down the window for energy consumption step that results in substrate transition into the TolC-channel, expanding the current understanding of the efflux cycle of the MacB-based tripartite assemblies. Based on that we propose a modified model of the MacB cycle within the context of tripartite complex assembly.
Correction: Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic applications
Authors: Wang Shiqi , Fontana Flavia , Shahbazi Mohammad-Ali , Santos Hélder A.
Published: April 2021

Correction for ‘Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic applications’ by Shiqi Wang et al., Chem. Commun., 2021, DOI: 10.1039/d1cc00811k.
Rational engineering of Acinetobacter tandoii glutamate dehydrogenase for asymmetric synthesis of l-homoalanine through biocatalytic cascades
Authors: Wang Liuzhu , Diao Shiqing , Sun Yangyang , Jiang Shuiqin , Liu Yan , Wang Hualei , Wei Dongzhi
Published: April 2021

A high yield of l-homoalanine can be obtained by an engineered dual cofactor-dependent GluDH in a cascade without the addition of NAD(P)H.
Thermo- and photoinduced spin state switching in an iron(ii) 2D coordination network associated with large light-induced thermal hysteresis and tuning of dimensionalityvialigand modulation
Authors: Ghosh Subrata , Kamilya Sujit , Pramanik Titas , Mohanty Ashutosh , Rouzières Mathieu , Herchel Radovan , Mehta Sakshi , Mondal Abhishake
Published: April 2021

High-spin mononuclear complexes and a multi-stimuli responsive 2D iron(ii) coordination network obtainedviaethylenedioxythiophene based ligand modulation have been explored.
Ethylene glycol-mediated one-pot synthesis of Fe incorporated α-Ni(OH)2 nanosheets with enhanced intrinsic electrocatalytic activity and long-term stability for alkaline water oxidation
Authors: Tudu Gouri , Ghosh Sourav , Ganguli Sagar , Koppisetti Heramba V. S. R. M. , Inta Harish Reddy , Mahalingam Venkataramanan
Published: April 2021

Iron incorporated α-nickel hydroxide [Ni0.8Fe0.2(OH)2] nanosheets prepared from N,N,N′,N′-Tetramethylethane-1,2-diamine and ethylene glycol acts as an efficient electrocatalyst with remarkable stability for alkaline water oxidation.
The contribution of metalloporphyrin complexes in molecular sensing and in sustainable polymerization processes: a new and unique perspective
Authors: Strianese Maria , Pappalardo Daniela , Mazzeo Mina , Lamberti Marina , Pellecchia Claudio
Published: April 2021

The review summarizes recent developments of metalloporphyrins as optical probes for biologically relevant molecules and as catalysts for the preparation of sustainable polymers such as polyesters and polycarbonates.
Multimetal lanthanide phosphonocarboxylate frameworks: structures, colour tuning and near-infrared emission
Authors: Jing Huiru , Dan Wenyan , Zhu Jiaxing , Ling Yun , Jia Yu , Yang Yongtai , Liu Xiaofeng , Chen Zhenxia , Zhou Yaming
Published: April 2021

A series of isostructural (3,18)-connected lanthanide phosphonocarboxylate frameworks were designed by using Ln7-clusters as SBUs, which served as a platform to accommodate various lanthanide ions for integrating multi-luminescence properties.
Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies
Authors: Moseev Timofey D. , Varaksin Mikhail V. , Gorlov Denis A. , Charushin Valery N. , Chupakhin Oleg N.
Published: April 2021

This review highlights the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C–C coupling reactions for the period from 2006 to the beginning of 2021.
Design and development of highly sensitive PEDOT-PSS/AuNP hybrid nanocomposite-based sensor towards room temperature detection of greenhouse methane gas at ppb level
Authors: Khasim Syed , Pasha Apsar , Badi Nacer , Ltaief Adnen , Al-Ghamdi S. A. , Panneerselvam Chellasamy
Published: April 2021

Fabrication of novel methane sensor based on PEDOT-PSS:AuNPs composite treated with DMSO and Zonyl using spin coating technique.
High efficiency solar desalination and dye retention of plasmonic/reduced graphene oxide based copper oxide nanocomposites
Authors: Kospa Doaa A. , Ahmed Awad I. , Samra Salem E. , Ibrahim Amr Awad
Published: April 2021

Water desalination via solar-driven interfacial evaporation is one of the most essential technologies to limit the problem of global freshwater scarcity.
Fluorinated Iron(ii) clathrochelate units in metalorganic based copolymers: improved porosity, iodine uptake, and dye adsorption properties
Authors: Shetty Suchetha , Baig Noorullah , Hassan Atikur , Al-Mousawi Saleh , Das Neeladri , Alameddine Bassam
Published: April 2021

We report the synthesis of metalorganic copolymers made from the palladium catalyzed Sonogashira cross-coupling reaction between various iron(ii) clathrochelate building blocks with diethynyl–triptycene and fluorene derivatives.
Origin of MnO induced Cu0/Cu+ surface active centers for CO2 containing syngas conversion to DME via tandem catalysis
Authors: Tripathi Komal , Asthana Sonal , Singh Rajan , Pant Kamal Kishore , Upadhyayula Sreedevi
Published: April 2021

The chemical metamorphosis of a feed comprising carbon oxides (CO + CO2) in an H2-lean environment into methanol/DME is a versatile technology to meet sustainable energy demand and partially neutralize the enormous emissions of CO2 into the atmosphere.
Multi-length scale 5D diffraction imaging of Ni–Pd/CeO2–ZrO2/Al2O3 catalyst during partial oxidation of methane
Authors: Matras Dorota , Vamvakeros Antonis , Jacques Simon D. M. , di Michiel Marco , Middelkoop Vesna , Ismagilov Ilyas Z. , Matus Ekaterina V. , Kuznetsov Vadim V. , Cernik Robert J. , Beale Andrew M.
Published: April 2021

Operando 5D X-ray diffraction imaging reveals complex heterogeneities across multiple length scales in a catalytic reactor for the partial oxidation of methane reaction.
Energy and environmental catalysis driven by stress and temperature-variation
Authors: Wang Jingjing , Hu Cheng , Shi Lei , Tian Na , Huang Hongwei , Ou Hongling , Zhang Yihe
Published: April 2021

This review provides a comprehensive overview of energy and environmental catalysis driven by stress and temperature variation based on piezoelectric and pyroelectric effects.
The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting
Authors: Alaaeddine Rana A. , AlZaim Ibrahim , Hammoud Safaa H. , Arakji Aya , Eid Ali H. , Abd-Elrahman Khaled S. , El-Yazbi Ahmed F.
Published: April 2021

Antithrombotic drugs are widely used for primary and secondary prevention, as well as treatment of many cardiovascular disorders. Over the past few decades, major advances in the pharmacology of these agents have been made with the introduction of new drug classes as novel therapeutic options. Accumulating evidence indicates that the beneficial outcomes of some of these antithrombotic agents are not solely related to their ability to reduce thrombosis. Here, we review the evidence supporting established and potential pleiotropic effects of four novel classes of antithrombotic drugs, adenosine diphosphate (ADP) P2Y12-receptor antagonists, Glycoprotein IIb/IIIa receptor Inhibitors, and Direct Oral Anticoagulants (DOACs), which include Direct Factor Xa (FXa) and Direct Thrombin Inhibitors. Specifically, we discuss the molecular evidence supporting such pleiotropic effects in the context of cardiovascular disease (CVD) including endothelial dysfunction (ED), atherosclerosis, cardiac injury, stroke, and arrhythmia. Importantly, we highlight the role of DOACs in mitigating metabolic dysfunction-associated cardiovascular derangements. We also postulate that DOACs modulate perivascular adipose tissue inflammation and thus, may reverse cardiovascular dysfunction early in the course of the metabolic syndrome. In this regard, we argue that some antithrombotic agents can reverse the neurovascular damage in Alzheimer’s and Parkinson’s brain and following traumatic brain injury (TBI). Overall, we attempt to provide an up-to-date comprehensive review of the less-recognized, beneficial molecular aspects of antithrombotic therapy beyond reduced thrombus formation. We also make a solid argument for the need of further mechanistic analysis of the pleiotropic effects of antithrombotic drugs in the future.
Halomonasas a chassis
Authors: Ye Jian-Wen , Chen Guo-Qiang
Published: April 2021

With the rapid development of systems and synthetic biology, the non-model bacteria, Halomonas spp., have been developed recently to become a cost-competitive platform for producing a variety of products including polyesters, chemicals and proteins owing to their contamination resistance and ability of high cell density growth at alkaline pH and high salt concentration. These salt-loving microbes can partially solve the challenges of current industrial biotechnology (CIB) which requires high energy-consuming sterilization to prevent contamination as CIB is based on traditional chassis, typically, Escherichia coli, Bacillus subtilis, Pseudomonas putida and Corynebacterium glutamicum. The advantages and current status of Halomonas spp. including their molecular biology and metabolic engineering approaches as well as their applications are reviewed here. Moreover, a systematic strain engineering streamline, including product-based host development, genetic parts mining, static and dynamic optimization of modularized pathways and bioprocess-inspired cell engineering are summarized. All of these developments result in the term called next-generation industrial biotechnology (NGIB). Increasing efforts are made to develop their versatile cell factories powered by synthetic biology to demonstrate a new biomanufacturing strategy under open and continuous processes with significant cost-reduction on process complexity, energy, substrates and fresh water consumption.
The Neural Circuitry Underlying the “Rhythm Effect” in Stuttering
Authors: Frankford Saul A. , Heller Murray Elizabeth S. , Masapollo Matthew , Cai Shanqing , Tourville Jason A. , Nieto-Castañón Alfonso , Guenther Frank H.
Published: April 2021

Purpose

Stuttering is characterized by intermittent speech disfluencies, which are dramatically reduced when speakers synchronize their speech with a steady beat. The goal of this study was to characterize the neural underpinnings of this phenomenon using functional magnetic resonance imaging.

Method

Data were collected from 16 adults who stutter and 17 adults who do not stutter while they read sentences aloud either in a normal, self-paced fashion or paced by the beat of a series of isochronous tones (“rhythmic”). Task activation and task-based functional connectivity analyses were carried out to compare neural responses between speaking conditions and groups after controlling for speaking rate.

Results

Adults who stutter produced fewer disfluent trials in the rhythmic condition than in the normal condition. Adults who stutter did not have any significant changes in activation between the rhythmic condition and the normal condition, but when groups were collapsed, participants had greater activation in the rhythmic condition in regions associated with speech sequencing, sensory feedback control, and timing perception. Adults who stutter also demonstrated increased functional connectivity among cerebellar regions during rhythmic speech as compared to normal speech and decreased connectivity between the left inferior cerebellum and the left prefrontal cortex.

Conclusions

Modulation of connectivity in the cerebellum and prefrontal cortex during rhythmic speech suggests that this fluency-inducing technique activates a compensatory timing system in the cerebellum and potentially modulates top-down motor control and attentional systems. These findings corroborate previous work associating the cerebellum with fluency in adults who stutter and indicate that the cerebellum may be targeted to enhance future therapeutic interventions.

Supplemental Material

https://doi.org/10.23641/asha.14417681
Generational Differences in Work Ethic Among Speech-Language Pathologists
Authors: McCullough Helga M. , Gaugler Trent
Published: April 2021

Purpose

To date, there is limited available research with a specific focus on the potential differences in work ethic among speech-language pathologists from different social generations. The purpose of this study was to provide a better understanding of the work ethic profile of three generations of speech-language pathologists and, in particular, of any differences in work ethic profiles among the three generations.

Method

This study used a quantitative, nonexperimental, cross-sectional design to better understand work ethic among the three generations of speech-language pathologists through the use of an online survey containing the Multidimensional Work Ethic Profile–Short Form.

Results

The 814 surveys analyzed indicated that the three distinct generations of speech-language pathologists exhibited differences in four out of the seven dimensions of work ethic.

Conclusions

Through this study, the authors developed a work ethic profile for each of the three generations of speech-language pathologists licensed in the Commonwealth of Pennsylvania. While there were some similarities in the dimensions of work ethic among the three generational cohorts, statistically significant differences were discovered in the dimensions of Morality/Ethics, Leisure, Centrality of Work, and Wasted Time. Understanding differences in work ethic could be beneficial to employers, administrators, and supervisors for recruitment and retention purposes as well as to speech-language pathologists who work with colleagues of different generational cohorts.
Pulsars with NenuFAR: Backend and pipelines
Authors: Bondonneau L. , Grießmeier J.-M. , Theureau G. , Cognard I. , Brionne M. , Kondratiev V. , Bilous A. , McKee J. W. , Zarka P. , Viou C. , Guillemot L. , Chen S. , Main R. , Pilia M. , Possenti A. , Serylak M. , Shaifullah G. , Tiburzi C. , Verbiest J. P. W. , Wu Z. , Wucknitz O. , Yerin S. , Briand C. , Cecconi B. , Corbel S. , Dallier R. , Girard J. N. , Loh A. , Martin L. , Tagger M. , Tasse C.
Published: April 2021

Context.NenuFAR (New extension in Nançay upgrading LOFAR) is a new radio telescope developed and built on the site of the Nançay Radio Observatory. It is designed to observe the largely unexplored frequency window from 10 to 85 MHz, offering a high sensitivity across its full bandwidth. NenuFAR has started its “early science” operation in July 2019, with 58% of its final collecting area.

Aims.Pulsars are one of the major phenomena utilized in the scientific exploitation of this frequency range and represent an important challenge in terms of instrumentation. Designing instrumentation at these frequencies is complicated by the need to compensate for the effects of both the interstellar medium and the ionosphere on the observed signal. We have designed a dedicated backend and developed a complete pulsar observation and data analysis pipeline, which we describe in detail in the present paper, together with first science results illustrating the diversity of the pulsar observing modes.

Methods.Our real-time pipeline LUPPI (Low frequency Ultimate Pulsar Processing Instrumentation) is able to cope with a high data rate and provide real-time coherent de-dispersion down to the lowest frequencies reached by NenuFAR (10 MHz). The full backend functionality is described, as the available pulsar observing modes (folded, single-pulse, waveform, and dynamic spectrum).

Results.We also present some of the early science results of NenuFAR on pulsars: the detection of 12 millisecond pulsars (eight of which are detected for the first time below 100 MHz); a high-frequency resolution mapping of the PSR B1919+21 emission profile and a detailed observation of single-pulse substructures from PSR B0809+74 down to 16 MHz; the high rate of giant-pulse emission from the Crab pulsar detected at 68.7 MHz (43 events per minute); and the illustration of the very good timing performance of the instrumentation, which allows us to study dispersion measure variations in great detail.
Food combinatorics in the production of dehydrated products for a healthy diet
Authors: Strizhevskaya Victoria , Pavlenkova Marina , Nosachyova Nataliya , Simakova Inna
Published: April 2021

The aim of the study was to develop compositions of dehydrated products for a healthy diet using the principles of food combinatorics. Two types of snack products from plant materials were developed as objects of study. The study was performed by the calculation method the nutritional value was calculated according to the tables of chemical composition and based on these recommendations on the use of vitamins for men and women (2 groups of labor intensity). Vitamins and biologically active substances (flavonoids) were analyzed by reverse phase HPLC. Dehydration was carried out using resonance IR drying. The selection of adaptogenic plant raw materials, the calculation of acceptable ratios made it possible to predict the replenishment of the needs of the human body for the following substances: vitamin A from 12 to 15%, while the estimated amount of provitamins A, such as β-carotene and lycopene, compensates for this need significantly from 79 to 127 % of daily allowance, vitamin K from 88 % to 131 %, native dietary fiber from 35 % to 51 % of the recommended daily allowance, depending on the ratio of components in the predicted compositions.
Tea Antioxidants
Authors: Deineka Ludmila , Zhakiyanova Aigerim , Amrenova Yenglik , Blinova Irina
Published: April 2021

In thе paper, antioxidant activity (AOA) of tea infusions as a function of infusion time and type or brand of teas as well as a concentration of caffeine were measured. The main components of green tea infusions are identified as epigallocatechin gallate (EGCG), epicatechin gallate (ECG), and caffeine. It has been shown that the antioxidant activity depends on the time of infusion and the degree of tea grinding. while there is a linear dependence between AOA and concentration of caffeine in tea. Thus the only method to reduce content of caffeine in the infusion is a preliminary withdrawal of caffeine from the plant material
The research of international and national educational standards on leadership development for pharmacy students
Authors: Aliekperova Nataliia
Published: April 2021

To estimate the level of usage of leadership development opportunities, International Pharmaceutical Federation official data and national educational and professional standards for pharmacy students in such countries as the USA, the United Kingdom, Australia, and Canada have been analyzed. According to the results, leadership knowledge and skills are of great importance to provide people with advanced pharmaceutical care. The most common leadership abilities for students getting pharmaceutical education deal with personal leadership (self-awareness, self-motivation, emotional intelligence, innovative mindset), teamwork, effective collaboration with other health professionals, building of a shared vision, resulting in the ability to become a change agent for sustainable development and improvement of health care system.
The expert evaluation systems in drug development
Authors: Zhilyakova Elena , Savin Ok , Baskakova Alexandra , Avtina Natalia
Published: April 2021

This study investigates the unique properties and criteria of use intellectual systems in drug delivery. The traditional methods of pharmaceutical drug development are limited in the field of usability. In connection with the above mentioned, the task of development and creation of the intellectual system allowing to choose active pharmaceutical ingredients, auxiliary substances, which will be based on the expert system and information base of knowledge in the field of pharmaceutical production and it should be of current scientific and practical relevance. The most commonly used type of intelligent systems today are expert systems, which are computer systems capable of partially replacing a highly qualified specialist in his or her field of competence through the knowledge previously obtained from him or her. That is why expert systems are accepted to be considered together with knowledge bases, which are models of specialists’ behavior in a certain field, and for decision-making procedures of logical conclusion are applied. The field of application of expert systems is absolutely unlimited. A vivid example is their use in diagnostic tasks of modern medicine.
Species composition of green frogs (Pelophylax Esculentus Complex) of the Belgorod agglomeration based on DNA markers
Authors: Snegin Eduard , Barkhatov Anatoliy , Sychev Anton , Snegina Elena
Published: April 2021

On the basis of molecular genetic analysis of the intron-1 of the nuclear serum albumin gene (SAI-1) were identified 177 individuals of Pelophylax esculentus complex of 9 localities Belgorod. Two types of population systems R and RE were identified. Pure populations of L-type, E-type and LE-type as well as P. lessonae individuals were not identified.
Analysis of 16S rRNA gene variability in soil nitrifying bacteria of the genus Nitrosomonas
Authors: Nechayeva Anastasia , Boyarshin Konstantin , Bespalova Olga , Klyueva Violetta , Makanina Olesya , Batlutskaya Irina
Published: April 2021

The main goal of the work was to assess variability of 16S rRNA gene sequence within the nitrifying bacterial genus Nitrosomonas to find specific sequences for its detection. To achieve it, we had to find and to assess sequences that are highly conservative on the level of the genus and to find and to assess sequences variable on the level of genus but conserved on the level of species. In the SILVA database of ribosomal RNA sequences, 231 sequences of 16S rRNAs of bacteria of the genus Nitrosomonas were collected, of which were sorted 132 sequences by length from 1400 to 1541 (full-sized gene) nucleotides. We conducted an analysis of the taxon-specificity of sequences conserved at the genus level. More than a hundred full matches were found by the BLAST program in the nr database with other genera of the same and other families. So, in Nitrosomonas 16S rRNA gene are present some highly conservative regions, but they are not genus-specific due to high coincidence with other genera. Wherein, a variable region 994-1041 is highly species-specific for the species N. eutropha. Generally, the sequence of 994-1041 region of Nitrosomonas 16S rRNA genes tends to be clustered, being very close between some species.
Comparative description of the anti-inflammatory action of the food concentrate “Enoant” and resveratrol in the model of an acute exudative inflammation
Authors: Tribrat Natalia , Birukova Elena , Khusainov Denis , Dzheldubaeva Elviza , Tribrat Alexandr , Chornobay Svitlana
Published: April 2021

The paper considers comparing the anti-inflammatory action of the food concentrate “Enoant” and a classical antioxidant – resveratrol in the doses of 20 mg/kg in the model of an acute exudative inflammatory of animals. It was proved that resveratrol had the most anti-inflammatory action; this was manifested by a considerable decrease of the increase rate of the animal paw’s size in the formalin test after 7 and 14 days of taking the antioxidant. The food concentrate “Enoant” demonstrated anti-inflammatory properties after 7 days of taking the antioxidant; this was manifested by the increase of the animal paw’s size in the formalin test, however 14 days later a moderate anti-inflammatory reaction was registered, this was manifested by the decrease of the increase rate of the animal paw’s size in the formalin test..
To be raised up or kicked out? Insights for the recycler in closed-loop supply chain with the regulation of government
Authors: Wu Qunli , Xu Xinxin
Published: April 2021

In order to improve the recovery rate of waste products and maximize the social welfare, this paper investigates the problem of government setting a recovery rate threshold for the recycler in the closed-loop supply chain (CLSC) with the information asymmetry. By establishing the government incentive regulation model, the government can disclose the true recovery cost of the recycler and guide the recycler to make an reasonable effort. In this study, our model obtains the best recovery rate threshold for the recycler from the perspective of maximizing social welfare. Then, we conduct some sensitivity analyses and explore the impacts of related factors on the strategies-making of government and supply chain players. The results of the study indicates that the recovery rate threshold set not only depends on the operation efficiency of the recycler, it also affected by the consumers behavior and the production efficiency of manufacturer. The government should not pursue a high recovery rate blindly, more attention should be paid to control the cost of effort made by the recycler. With the increasing of the negative utility for the recycler to make effort, the government will improve the recovery threshold, otherwise, the threshold will decrease. The results facilitate scientific incentive mechanism development, and provide a reference for promoting CLSC operations.
A hybrid NSGA-II algorithm for the closed-loop supply chain network design in e-commerce
Authors: Shafiee Moghadam Shayan , Aghsami Amir , Rabbani Masoud
Published: April 2021

Designing the supply chain network is one of the significant areas in e-commerce business management. This concept plays a crucial role in e-commerce systems. For example, location-inventory-pricing-routing of an e-commerce supply chain is considered a crucial issue in this field. This field established many severe challenges in the modern world, like maintaining the supply chain for returned items, preserving customers’ trust and satisfaction, and developing an applicable supply chain with cost considerations. The research proposes a multi-objective mixed integer nonlinear programming model to design a closed-loop supply chain network based on the e-commerce context. The proposed model incorporates two objectives that optimize the business’s total profits and the customers’ satisfaction. Then, numerous numerical examples are generated and solved using the epsilon constraint method in GAMS optimization software. The validation of the given model has been tested for the large problems via a hybrid two-level non-dominated sort genetic algorithm. Finally, some sensitivity analysis has been performed to provide some managerial insights.
Design of a compact electron radiography system with electron source from laser wakefield accelerator
Authors: Xiao Chaofan , Xu Zhiyi , Lu Haiyang , Liu Jiaxin , Xie Chengzhi , Zhao Yanying , Geng Yixing , Huang Senlin , Zhao Sheng , Zhu Jungao , Lai Meifu , Zhang Hua , Zhuo Hongbin , Zhou Cangtao , Yan Xueqing
Published: April 2021

A compact electron radiography system has been designed with high gradient permanent magnet quadrupoles with 2.5 times magnification. Quasi-monoenergetic electron bunches with energies ranging from 100 to 200 MeV are generated from a laser wakefield accelerator (LWFA) acting as the electron source for the system. A matching segment composed of three quadrupoles before the objective plane creates a correlation between the position and the angle for the electrons, illuminating the observed object improved the resolution of the system. We expect electron radiography with 100-MeV ultrafast electron bunches to be widely adopted for many applications, especially considering the micron-level spatial resolution and sub-picosecond temporal resolution of the electron source from the LWFA. Since the laser system needed for generating 100–200 MeV electrons using the LWFA is roughly around 40 TW, the whole system can be effectively table-top in size, which is favorable for movable applications.
The performance prediction of current drive by the upgraded neutral beam on EAST
Authors: Wang Ji , Chen Jiale , Wu Bin , Chen Yuqing , Yang Zhen , Hu Chundong , Xie Yuanlai , Xie Yahong , Zhang Xuexi
Published: April 2021

The neutral beamline originally located on Port F is being modified to Port D and the injection direction is changed from clockwise injection (counter-IP) to counterclockwise injection (co-IP) on EAST. The operational quality of the two neutral beamlines will also be upgraded in the following months. The neutral beam current drive (NBCD) of the two upgraded beamlines is substantially improved due to the change from the balanced-injection to the same direction injection with the plasma current by simulation with ONETWO/NUBEAM and TRANSP/NUBEAM codes. Discharge scenarios with the typical parameters are modeled to evaluate NBCD performances for the upgraded beams at beam energy below 70 keV. The maximal NBCD in the prediction exceeds 117 kA which is much higher than the previous level. The simulation results indicate that NBCD after the upgrade are improved with the increase of the beam power and electron temperature Te. The increased plasma density can result in a decrease in NBCD, but it will also lead to a substantial increase in bootstrap current which occupies the dominant fraction of non-induced current. The NBCD can be partly enhanced due to the reduction of the electron shielding effect with the proper increase of

Z

e
f
f

.

These simulation results demonstrate the performances of NBCD after beams upgrade, and can also provide some valuable guidance for future experiments on EAST.
M-shape and W-shape bright incite by the fluctuations of the polarization in a-helix protein
Authors: Abbagari Souleymanou , Douvagaï Douvagaï , Houwe Alphonse , Doka Serge Y , Inc Mustafa , Crepin Kofane T
Published: April 2021

In this work, under consideration is the coupled system of nonlinear Schrödinger (NSL) and Boussinesq equations that serves as model to study the polarization fluctuation in α-helical protein. M-shaped and W-shaped solutions have been derived through the new modified Sardar sub-equation technique (SSEM). These solitons solutions define the polarization dynamics in the α-helical protein. The integration naturally leads to a constraint condition placed on the solitary wave variables which must hold for the solitary waves to exist. In addition, the standard linear stability analysis has permitted to study the behavior of the Modulation Instability (MI) gain spectra. Numerical simulation and physical interpretations of the acquired results are demonstrated. The derived structure of the acquired solutions give a rich platform to better understand the nonlinear dynamics in the α-helical protein.
Study of the high lying electric dipole excitations in Odd-A 153–159Eu isotopes
Authors: Tabar E , Yakut H , Kuliev A A , Quliyev H , Hoşgör G , Kemah E
Published: April 2021

In this paper, we have studied the electric dipole (E1) transitions in odd-mass 153–159Eu nuclei within Translational+Galilean Invariant Quasiparticle Phonon Nuclear Model (TGI-QPNM). Within the scope, the Giant and Pygmy Dipole Resonances (GDR and PDR) have been investigated in the energy range of 5–20 MeV. The numerical results show that the contribution of PDR and GDR to the total E1 strength is 2% and 98%, respectively. It has been found that the TGI-QPNM predicts the double hump structure and that the agreement between theoretical results and the existing experimental data is perfect, especially near the neutron binding energy Sn and the first hump of the GDR. Also the comparison of the theoretical results and the existing experimental data shows reasonable agreement for the integrated moments of the cross-sections in the GDR region. We can also deduce from the structure analysis of excited states the studied isotopes, that the GDR states can be considered to be more collective than the PDR states.
Stationary distribution extinction and optimal control for the stochastic hepatitis B epidemic model with partial immunity
Authors: Din Anwarud , Li Yongjin
Published: April 2021

In this paper, a stochastic model (with random noise transmission) is designed. The model possesses substantial potential to describe the dynamical behavior of the Hepatitis B (HBV) virus and it’s control by applying the strategy of vaccinating an offspring. The number of basic reproductive is calculated and proved that the system holds some sharp threshold properties. It is investigated that the model has a bounded, unique and positive solution subject to initial positive data. Furthermore, the stability of the investigated system has been presented by using stochastic Lyapunov functional theory. Stationary distribution and extinction of the infection are examined by providing sufficient conditions. To control the spread of the disease through some external measures, we used optimal control theory and analyzed stochastic as well as deterministic control problems. For further verification of the obtained analytical results, additional graphical solutions have been presented for the ease of understanding. This study may provide a strong theoretical basis for understanding worldwide chronic infectious diseases.
The persistence of large scale structures. Part I. Primordial non-Gaussianity
Authors: Biagetti Matteo , Cole Alex , Shiu Gary
Published: April 2021

We develop an analysis pipeline for characterizing the topology of large scale structure and extracting cosmological constraints based on persistent homology. Persistent homology is a technique from topological data analysis that quantifies the multiscale topology of a data set, in our context unifying the contributions of clusters, filament loops, and cosmic voids to cosmological constraints. We describe how this method captures the imprint of primordial local non-Gaussianity on the late-time distribution of dark matter halos, using a set of N-body simulations as a proxy for real data analysis. For our best single statistic, running the pipeline on several cubic volumes of size 40 (Gpc/h)3, we detect fNL
loc=10 at 97.5% confidence on ∼ 85% of the volumes. Additionally we
test our ability to resolve degeneracies between
the topological signature of fNL
loc and variation of σ8 and argue that correctly identifying nonzero fNL
loc in this case is possible via an optimal template method. Our method relies on information living at 𝒪(10) Mpc/h, a complementary scale with respect to commonly used methods such as the scale-dependent bias in the halo/galaxy power spectrum. Therefore, while still requiring a large volume, our method does not require sampling long-wavelength modes to constrain primordial non-Gaussianity. Moreover, our statistics are interpretable: we are able to reproduce previous results in certain limits and we make new predictions for unexplored observables, such as filament loops formed by dark matter halos in a simulation box.
Two-proton radioactivity of exotic nuclei beyond proton drip-line
Authors: Wang Yanzhao , Cui Jianpo , Gao Yonghao , Gu Jianzhong
Published: April 2021

To search for new candidates of the true and simultaneous two-proton (2p) radioactivity, the 2p decay energies (Q
2p
) are extracted by the Weizsäcker–Skyrme-4 (WS4) model, the finite-range droplet model (FRDM), the Koura–Tachibana–Uno–Yamada (KTUY) model and the Hartree–Fock–Bogoliubov mean-field model with the BSk29 Skyrme interaction (HFB29). Then, the 2p radioactivity half-lives are calculated within the generalized liquid drop model by inputting the four types of Q
2p
values. By the energy and half-life constraints, it is found that the probable 2p decay candidates are the nuclei beyond the proton-drip line in the region of Z ≤ 50 based on the WS4 and KTUY mass models. For the FRDM mass model, the probable 2p decay candidates are found in the region of Z ≤ 44. However, the 2p-decaying candidates are predicted in the region of Z ≤ 58 by the HFB29 mass model. It means that the probable 2p decay candidates of Z > 50 are only predicted by the HFB29 mass model. Finally, the competition between the true 2p radioactivity and α-decay for the nuclei above the N = Z = 50 shell closures is discussed. It is shown that 101Te, 111Ba and 114Ce prefer to 2p radioactivity and the dominant decay mode of 107Xe and 116Ce is α-decay.
High energy window for probing dark matter with cosmic-ray antideuterium and antihelium
*
Authors: Ding Yu-Chen , Li Nan , Wei Chun-Cheng , Zhou Yu-Feng
Published: April 2021

Cosmic-ray (CR) anti-nuclei are often considered important observables for indirect dark matter (DM) detection at low kinetic energies, below GeV per nucleon. Since the primary CR fluxes drop quickly towards high energies, the secondary anti-nuclei in CR are expected to be significantly suppressed in high energy regions (
\begin{document}$\gtrsim 100$\end{document}
GeV per nucleon). If DM particles are heavy, the annihilation productions of DM can be highly boosted, and thus the fluxes of anti-nuclei produced by DM annihilation may exceed the secondary background at high energies, which opens a high energy window for indirect DM detection. We investigate the possibility of detecting heavy DM particles which annihilate into high energy anti-nuclei. We use the Monte Carlo generators PYTHIA, EPOS-LHC and DPMJET and the coalescence model to simulate the production of anti-nuclei, and constrain the DM annihilation cross-sections by using the AMS-02 and HAWC antiproton data and the HESS galactic center
\begin{document}$ \gamma $\end{document}
-ray data. We find that the conclusion depends on the choice of DM density profiles. For the “Cored” type profile with a DM particle mass
\begin{document}$\gtrsim 10$\end{document}
TeV, the contributions from DM annihilation can exceed the secondary background in high energy regions, which opens the high energy window, while for the “Cuspy” type profile, the excess disappears.
Analysis of Zcs
(3985) as the axialvector tetraquark state *
Authors: Wang Zhi-Gang
Published: April 2021

In this study, we choose the scalar and axialvector diquark operators in the color antitriplet as the fundamental building blocks to construct four-quark currents and investigate the diquark-antidiquark type axialvector tetraquark states

in the framework of the QCD sum rules. The predicted tetraquark mass

is in excellent agreement with the experimental value

from the BESIII collaboration, which supports identifying

as the cousin of

with quantum numbers

. We take into account the light flavor

mass-breaking effect to estimate the mass spectrum of the diquark-antidiquark type hidden-charm tetraquark states with strangeness according to previous studies.
Exploring the halo phenomena of medium-mass nuclei having approximately Z= 40 with point-coupled parameters in complex momentum representations *
Authors: Chu Yao-Wu , Heng Tai-Hua
Published: April 2021

To explore the properties of neutron-rich nuclei with approximately 40 protons, the density-dependent point coupling (DD-PC1) effective interaction parameter is adopted in the relativistic mean-field theory with the complex momentum representation (RMF-CMR). The calculated two-neutron separation energy (S
2n
) and root-mean-square (rms) radii support the halo structure that appear in Mo and Ru isotopic chains. Besides, the neutron skin structures appear in Kr and Sr isotopes. The conclusions drawn are also supported by the single-particle energy levels and their occupancy probability and density distribution. Particularly, the energy levels, which reduce to bound states or are approximately 0 MeV with a small orbital angular momentum, are suggested to provide the primary contribution to increasing the neutron radius. Moreover, the single-particle energy levels significantly reflect the shell structure. In addition, the neutron drip line nuclei for Kr, Sr, Mo, and Ru elements are proposed via the changes in S
2n
.