bluuebunny/crossref_metadata_2025 huggingface dataset:
Limites
Authors: Araújo Katya de Azevedo , Anchieta Kellen Gurgel , Rosa Laura Ward da , Schmal Luciana Saraiva , Ferreira Tamara B. Jansen
Published: July 2023

A partir do estudo da obra de Freud e de Jacques Lacan, nos deteremos, no presente trabalho, na questão da importância dos Limites – Tema Oficial deste XXIII Congresso Brasileiro de Psicanálise – e do conceito de Lacan do Nome-do-Pai para a constituição do sujeito do inconsciente, possibilitando o desenvolvimento da capacidade simbólica e, por consequência, a alteridade e o reconhecimento do Outro. Na cultura atual, são múltiplos os exemplos da falta de limites e da indiscriminação de papéis e dos espaços intersubjetivos e transubjetivos, numa tentativa de eliminar as diferenças intergeracionais. Apresentaremos um material clínico para ilustrar a falha da função paterna na instalação da interdição da relação mãe-filha e de suas consequências para o desenvolvimento adulto.
Matou o pai e foi ao cinema
Authors: Berger Daniela , Souza Rodrigo Luís Bispo
Published: July 2023

O objetivo deste trabalho é propor a releitura do parricídio a partir da perspectiva intersubjetiva, priorizando o estudo da teoria psicanalítica das configurações vinculares. Compreende- se o fenômeno do parricídio como resultado de um processo complexo, que transpõe o modelo edípico e incide sobre famílias severamente disfuncionais e com maltrato crônico, postuladas como conjeturas diagnósticas psicóticas. A fim de ilustrar a teoria, este trabalho faz aproximações com o caso clínico de uma família parricida, mostrando as articulações teórico-clínicas existentes. O presente estudo visa colaborar com um avanço no pensamento psicanalítico sobre a temática e suscitar indagações que possam propor mais estudos sobre a perspectiva intersubjetiva do parricídio a fim de expandir, atualizar e dinamizar os escritos sobre as conjeturas psicopatológicas vinculares.
Relações familiares e aprisionamento psíquico
Authors: Costa Gley P.
Published: July 2023

Há vários anos trabalhando como supervisor de cursos de especialização em Psiquiatria e Psicoterapia de orientação analítica, além de casos de análise, tenho observado que, quando o terapeuta se encontra diante de uma criança com uma perturbação do comportamento ou outro sintoma que supõe ter uma origem psicológica, na maioria das vezes, acertadamente, não hesita em investigar o seu contexto ambiental, concluindo com freqüência que o problema revelado pelo pequeno paciente provavelmente resulta de conflitos de interação do seu grupo familiar. Quase a mesma orientação costuma manter com os adolescentes, embora, na medida em que os anos dessa etapa da vida vão passando, cada vez mais se afasta dessa conduta. Diante de um adulto, a tendência é tomá-lo isoladamente, enquanto que a família a que pertence é equiparada a uma tela das suas projeções. Como resultado desta posição, ao longo do tratamento do paciente o terapeuta procura recriar essa rua de mão única, na qual passa a ocupar o lugar inicialmente atribuído à família, sem levar em consideração as projeções da família e as suas próprias projeções no paciente. Sem esquecer a participação do paciente, através deste trabalho procuro chamar a atenção para a influência dos objetos na formação do mundo interno, constituindo-se numa verdadeira “Assembléia de Cidadãos” que estabelece as suas determinações ao longo da vida do indivíduo
homem que viu o infinito
Authors: Katz Gildo
Published: July 2023

O autor, a partir do filme O homem que viu o infinito, procura relacionar a arte, a sublimação e a criatividade na psicanálise. Ao investigar as ideias do matemático Ramanujan considera que sua capacidade lembra a excepcional inteligência de Leonardo da Vinci. Para ele, ambos seguiam uma lógica na qual as representações do pensamento se articulavam numa perspectiva infinita. Considera que um excesso de subjetividade perturbava o espírito científico do matemático uma vez que, em seu intenso misticismo, imaginava suas equações sem entender o que elas significavam, pois as recebia em sonhos da deusa Namagiri. Chama a atenção para a relação entre a sublimação de pulsões que sucumbem ao recalque com a criatividade, porque a arte comunica algo a partir dos conflitos internos do artista. Finalmente, cita Freud, que sustentava que o que nos prende poderosamente a uma obra é a intenção desta em despertar em nós a mesma atitude emocional que produziu no artista o ímpeto de criar.
impacto do antissemitismo na teoria e na prática psicanalítica
Authors: Gerchmann Augusta
Published: July 2023

O artigo apresenta um panorama histórico das diversas formas de perseguição de que foi alvo o povo judeu, com vista a identificar de que maneira os atos de intolerância que se solidificaram no mundo moderno sob o epíteto de “antissemitismo” influenciaram o desenvolvimento da psicanálise. Com foco especial nos trabalhos de cunho teórico e biográfico do precursor da psicanálise, Sigmund Freud, identifica-se como suas experiências pessoais e sua ambivalência em face do pertencimento a esse povo perseguido contribuíram para a interpretação que nos legou acerca da mente humana. Nessa trilha, observa-se como a história da humanidade e de seus conflitos interferiram na formulação não apenas da teoria psicanalítica, mas também em sua prática clínica. Conclui-se que, apesar de se declarar agnóstico e não ter seguido, em sua vida privada, os costumes religiosos de seus antepassados, a identidade judaica de Freud e a história do preconceito étnico-religioso tiveram impacto marcante na construção da psicanálise.
Compartilhanho a experiência clínica
Authors: Junqueira Maria Regina , Franch Nilde J. Parada
Published: July 2023

A apresentação do material que se segue foi elaborada a partir do convite dos organizadores do XXIII Congresso da Fepal, em que foi solicitado às autoras que apresentassem e comentassem uma experiência clínica de análise de crianças. A exigüidade de tempo levou-as a uma escrita mais espontânea e descomprometida com o rigor de um trabalho científico. [...]
Palavras do editor
Authors: Katz Gildo
Published: July 2023

É com muita satisfação que estamos entregando este novo número de Psicanálise – Revista da SBPdePA que, como tem sido a tradição nesses cinco anos, contém contribuições de autores brasileiros, latino-americanos, norte americanos e europeus com o objetivo de circular novas idéias, novos conceitos e experiências atuais, que podem sugerir acréscimos ao legado freudiano para que a psicanálise sobreviva e se mantenha como uma das principais disciplinas que proporcionam conhecimento e possibilidades de integração desse conhecimento com a prática clínica. [...]
Novas perspectivas sobre as fantasias inconscientes
Authors: Grotstein James S.
Published: July 2023

O autor propõe novas perspectivas sobre as fantasias inconscientes. Procura demonstrar que os Sistemas Cs. e Ics. não funcionam em conflito, mas de modo complementar como oposições binárias. O Sistema Ics. tem dois maiores componentes, o Ics. não reprimido e o Ics. reprimido ou dinâmico, sendo o primeiro o Ics. platônico inato, e o último, o domínio das memórias reprimidas das experiências reais. O autor postula que o último é o depósito do processamento mental via sonhos e fantasias que se originam das atividades do primeiro. Os Sistemas Ics. e Cs. funcionam como braços opostos e cooperativos para interceptar “O” (a Verdade Absoluta sobre a Realidade Última). A formação da fantasia inconsciente, i.e., o funcionamento da função alfa, constitui o pensamento inconsciente. Os “atores” que desempenham as fantasias inconscientes são fantasmas ou demônios diversificados (ambos positivos e negativos) que representam um papel dramático esperando que, enquanto isso, alguém esteja lá para interpretar a sua pantomima, de modo que eles possam, como a esfinge em Oedipus Rex, ficar livres e retornar ao repertório. A interpretação psicanalítica da fantasia inconsciente os confirma e os completa, portanto, não desacreditando-os meramente. Sonhos e fantasias inconscientes são o nosso “serviço silencioso”.
Ferenczi e Winnicott
Authors: Borgogno Franco
Published: July 2023

Pensando antes na escrita destas notas, entre inúmeros compromissos, disse a mim mesmo, várias vezes: “eu deveria mostrar as idéias desses autores, não colocar as minhas”. [...]
Risk Factors of Malaria Infection among School-Aged Children in Rural-Urban Areas, Taraba State, Nigeria
Authors: Njilmah J. A. , Chintem D. G. W. , Akwa V. Y. , Wanmi D. A. , Iriekpen R. O. , Jonathan J. , Jerry T. J.
Published: July 2023

Introduction: Malaria is a mosquito born infectious disease of human and other animals caused by parasitic protozoans belonging to the genus Plasmodium. Malaria parasite among school aged children is a disease that poses a great challenge to human health in Nigeria. Malaria contributes significantly to the burden of disease especially among children less than five years. Efforts aimed in controlling malaria, prevalence is still high.

Study Design: This study was designed to investigate the risk factor associated with malaria infection among school aged children in Jalingo and Sardauna LGAs of Taraba State, Nigeria.

Place and Duration of Study: Urban-Rural areas (Jalingo ans Sardauna LGA Taraba State Nigria), studied from July-December 2022.

Methodology: Structured questionnaire was used to obtain demographic information and Microscopy was also used to determine Parasitaemia level among the school aged children (2-15years). A total of 1000 children less than 15 years old from ten (10) selected communities of the study areas whose parent or guardian gives consent were selected.

Results: The results revealed that out of the 1000 subjects, 359(35.9%) were infected with malaria parasites. Ages between 2-5 year were found to have the highest prevalence of 212(21.2%) while age 11-15 group had least prevalence of 21(2.1%). The overall prevalence of malaria parasite was moderate among the study population. This is probably due to the seasonal variation in malaria parasite intensity and the good knowledge of caregivers on malaria infection and management.

Conclusion: There is therefore the need to sustain the current media and health facility-based campaigns on malaria prevention strategy and maintenance of clean environmental condition.
Economic Analysis on the Production of Turmeric in Mamit District of Mizoram
Authors: Laltlanhlua  , Ramchandra
Published: July 2023

The present study was conducted in Mamit district of Mizoram. Totally 90 respondents were randomly selected and interviewed from the district. The data was gathered in the form of a pre-structured interview schedule. The study revealed that the average cost of cultivation of turmeric per hectare was incurred Rs. 74929.55 which was found to be Rs. 78857.73, Rs. 74003.41, and Rs. 71927.53 per hectare on Small, Semi-medium, and Medium respectively.

Input-output ratio related to cost C was (1:1.49) (1:1.66) and (1:1.89) on Small, Semi-medium, and Medium farmers respectively. When compared to medium farmers small farmers employed laborers for longer hours which resulted in a higher total cost of cultivation per ha.
Overcoming the Selectivity‐Sensitivity Trade‐Off in Electroactive Gas Sensing Using Hybrid Glass Composites
Authors: Sisman Orhan , Smirnova Oksana , Xia Yang , Greiner‐Mai Nadja , Reupert Aaron , Nozari Vahid , Velazquez Jose J. , Galusek Dusan , Knebel Alexander , Wondraczek Lothar
Published: January 2025

Hybrid glasses derived from meltable metal‐organic frameworks (MOFs) have emerged as a new class of amorphous materials. Combining the porosity of MOFs with the processing ability of glasses, they are thought to enable a wholly new range of functional compounds. By way of example, it is demonstrated here how the intrinsic porosity of glasses obtained from zeolitic imidazolates (ZIFs) can be used to overcome the selectivity‐sensitivity trade‐off in electroactive gas sensing. For this, composites are fabricated in which metallophthalocyanines are embedded within a ZIF‐62 MOF glass matrix. Such a material enables the detection of gas species (or their absence) utilizing the pronounced electrochemical sensitivity of phthalocyanines. Thereby, the solid glass does not only stabilize and protect the active component, but also – through its retained, highly tunable porosity – ensures sensor selectivity by molecular sieving and targeted size exclusion of larger molecules. In addition, the hydrophobicity of the ZIF pore interior protects the active component from degradation caused by ambient humidity. Investigations of the structural, optical and electronic properties of the composite indicate that compoundation is purely physical, that is, chemical interactions between the compound partners are avoided and the individual properties of the hybrid glass matrix and the electroactive metallophthalocyanine are retained. Atmosphere‐controlled high‐temperature electrical impedance measurements reveal significant shifts in resistance in CO2 and Ar atmosphere as compared to airflow. These results provide a proof of concept for sensitive and selective gas sensors based on such composites.
A Phase‐Transition–Free Sodium Vanadium Phosphate Cathode via Medium‐Entropy Engineering for Superior Sodium Ion Batteries
Authors: Wu Xiao‐Hui , Jiang Wei‐Jun , Dai Chen , Liu Li‐Zhong , Chai Yun , Zhao Ming‐Jun , Yang Li‐Bing , Lin Yuan , Zhao Yi , Huang Wei
Published: January 2025

Na3V2(PO4)3, based on multi‐electron reactions between V3+/V4+/V5+, is a promising cathode material for SIBs. However, its practical application is hampered by the inferior conductivity, large barrier of V4+/V5+, and stepwise phase transition. Herein, these issues are addressed by constructing a medium‐entropy material (Na3.2V1.1Ti0.2Al0.2Cr0.2Mn0.2Ni0.1(PO4)3, ME‐NVP) with strong ME─O bond and highly occupied Na2 sites. Benefiting from the medium‐entropy effect, ME‐NVP manifests a phase‐transition–free reaction mechanism, two reversible plateaus at 3.4 (V3+/V4+) and 4.0 V (V4+/V5+), and small volume change (2%) during Na+ insertion/extraction processes, as confirmed by comprehensive in/ex situ characterizations. Moreover, kinetics analysis illuminates the superior Na+ diffusion ability of ME‐NVP. Thus, the ME‐NVP cathode realizes remarkable rate capability of 67 mA h g−1 at 50C and a long‐term lifespan over 10 000 cycles (capacity retention of 81.3%). Theoretical calculations further illustrate that the weak binding of Na+ ion in the channel is responsible for the rapid Na+ diffusion, accounting for the superior reaction kinetics. Moreover, rigid MEO6 octahedral and feasible rearrangement of Na+ ions can suppress the phase transition, thus endowing an ultrastable ME‐NVP cathode. This work highlights the significant role of medium‐entropy engineering in advancing the output voltage, cycling stability, and rate capability of polyanionic cathodes.
Phytic Acid‐Induced Gradient Hydrogels for Highly Sensitive and Broad Range Pressure Sensing
Authors: Song Lei , Wang Zhenwu , Chen Shengjia , Shen Yi , Yin Jingbo , Wang Rong
Published: January 2025

Ionic conductive hydrogels have emerged as an excellent option for constructing dielectric layers of interfacial iontronic sensors. Among these, gradient ionic hydrogels, due to the intrinsic gradient elastic modulus, can achieve a wide range of pressure responses. However, the fabrication of gradient hydrogels with optimal mechanical and sensing properties remains a challenge. In this study, it is discovered first that phytic acid (PA) interacts in remarkably distinct manners (i.e., plasticizing effects and phase separation) with different polymers (i.e., polyacrylamide and polyacrylic acid). This distinctive PA‐polymer interacting mechanism is innovatively utilized to construct a modulus gradient ionic hydrogel through a simple precursor solution infiltration approach. The gradient hydrogel‐based flexible pressure sensor not only achieves a high sensitivity (9.00 kPa−1, <15 kPa) and a broad sensing range (from ≈3.7 Pa to 1.2 MPa) simultaneously, but also exhibits superior low pressure sensing performance. It successfully recognizes the subtle pressure due to acoustic waves and airflow, as well as the moderate pressure due to speaking and finger pressing and the high magnitude of plantar pressure. In addition, the gradient hydrogel demonstrates remarkable antibacterial properties and biocompatibility. This functional hydrogel with excellent sensing performance and bioactivity exhibits exceptional potential for wearable sensing applications.
Effect of Thermal Oxidation on the Structure, Surface Texturing, and Microstructure Evolution in Nanocrystalline Ga─O─N Films
Authors: Das Debabrata , Sanchez Francelia , Nalam Paul Gaurav , Herbort Nolan , Manciu Felicia S. , Shutthanandan V. , Ramana C.V.
Published: January 2025

An extensive examination of the nanoscale, crystallographic growth dynamics of the system, which is impacted by the thermal energy given to the GaN, is carried out to derive a deeper understanding of the growth kinetics, morphology and microstructure evolution, chemical bonding, and optical properties of Ga─O─N films. Thermal annealing of GaN films is performed in the temperature range of 900–1200 °C. Crystal structure, phase formation, chemical composition, surface morphology, and microstructure evolution of Ga─O─N films are investigated as a function of temperature. Increasing temperature induces surface oxidation, which results in the formation of stable β‐Ga2O3 phase in the GaN matrix, where the overall film composition evolves from nitride (GaN) to oxynitride (Ga─O─N). While GaN surfaces are smooth, planar, and featureless, oxidation induced granular‐to‐rod shaped morphology evolution is seen with increasing temperature to 1200 °C. The considerable texturing and stability of the nanocrystalline Ga─O─N on Si substrates can be attributed to the surface and interface driven modification because of thermal treatment. Corroborating with structure and chemical changes, Raman spectroscopic analyses also indicate that the chemical bonding evolution progresses from fully Ga─N bonds to Ga─O─N. While the GaN oxidation process starts with the formation of β‐Ga2O3 at an annealing temperature of 1000 °C, higher annealing temperatures induce structural distortion with the potential formation of Ga─O─N bonds. The structure‐phase‐chemical composition correlation, which will be useful for nanocrystalline materials for selective optoelectronic applications, is established in Ga─O─N films made by thermal treatment of GaN.
Catalyst‐Free Sequential Wolff Rearrangement and [3+3] Annulation of Enaminones and Diazo Compounds Enabling the Assembly of Highly Functionalized Pyridin‐4‐Ones
Authors: Wei Yuanzheng , Chen Longkun , Hu Huimin , Zhang Yu , Yang Shaolin , Xu Yu , Chen Li , Yu Fuchao
Published: January 2025

A general protocol for the efficient synthesis of a variety of highly functionalized pyridin‐4‐ones has been developed through a sequential Wolff rearrangement and [3+3] annulation reaction of enaminones and diazo compounds. This straightforward approach features wide substrate applicability, good substrate tolerance, moderate to excellent yields, and without any catalyst, and enables access to structurally diverse pyridin‐4‐one skeletons. Additionally, scale‐up experiments and synthetic derivatizations demonstrated the potential synthetic utility of the transformations.
Electronic CPA‐Laser Having Enhanced Sensitivity and Tunability
Authors: Yang Minye , Wang Lukang , Ye Zhilu , Zhong Qi , Jian Baolong , Zhang Xiaohui , Özdemir Şahin K. , Liu Ming
Published: January 2025

Exceptional point degeneracies, which are spectral singularities of non‐Hermitian systems, have been widely utilized for building optical, mechanical, or electrical sensing systems with much larger responses than those utilizing Hermitian degeneracies. However, such systems suffer from enhanced noise, which negates the enhanced response and thus does not provide any improvement in signal‐to‐noise ratio. Recently, the coherent perfect absorber (CPA)‐laser, which also utilizes non‐Hermitian singularity, has been used in sensing systems resulting in better noise robustness and enhanced responsivity. Nonetheless, CPA‐laser (CPAL) implementation requires all system parameters to be immutable, which hinders progress toward their practical use for sensing purposes. Here, a tunable electronic CPA‐laser is reported that overcomes these obstacles providing ultrahigh sensitivity as validated in the experiments for monitoring arterial pressure and respiration. This CPAL sensing scheme utilizes inductive coupling between gain and loss sub‐components and thereby the whole system can be decomposed into an active reader and a passive sensor, which enables better tunability and performance compared to previously reported CPAL systems. Moreover, the proposed CPAL system exhibits better performance compared to exceptional point‐based systems having a similar circuit structure. This research paves the way for exploring electronic CPAL for sensing applications and may have a profound impact on the next‐generation, ultrasensitive electromagnetic sensing system.
The impact of delayed adjuvant chemotherapy on survival in gastric cancer patients with and without preoperative chemotherapy
Authors: Shimonosono Masataka , Arigami Takaaki , Matsushita Daisuke , Tsuruda Yusuke , Sasaki Ken , Baba Kenji , Ohtsuka Takao
Published: January 2025

Aim

Adjuvant chemotherapy (AC) is the standard treatment for patients with advanced gastric cancer (GC), yet the optimal timing for its initiation remains unclear. Besides, no studies have definitively established when AC should begin in patients receiving preoperative chemotherapy (PC). This study aimed to determine the optimal timing for initiating AC in patients with GC who underwent curative gastrectomy, either with or without PC.

Methods

A total of 446 patients who underwent curative gastrectomy were evaluated, including 140 who received AC: 72 without PC and 68 with PC. Patients were categorized into two groups based on when they began AC: the early initiation group (within 8 weeks post‐surgery), and the late initiation group (8 weeks or later post‐surgery).

Results

In the non‐PC cohort, the 3‐year relapse‐free survival (RFS) rates were 71% in the early group versus 56% in the late group (p = 0.49), while the 3‐year overall survival (OS) rates were 94% versus 73% (p = 0.003). Similar trends were observed in the PC cohort; the 3‐year RFS rates were 59% versus 19% (p = 0.002), and the 3‐year OS rates were 69% versus 48% (p = 0.02). Multivariate analysis identified pretherapeutic distant metastasis (p < 0.001) and delayed AC initiation (≥8 weeks) (p = 0.001) as independent predictors of worse prognosis.

Conclusion

Delayed initiation of AC is associated with significantly poorer postoperative survival in patients with GC, irrespective of whether PC was administered. These findings emphasize the importance of timely AC initiation to improve long‐term outcomes in this patient population.
Photoinduced Late‐Stage Radical Decarboxylative and Deoxygenative Coupling of Complex Carboxylic Acids and Their Derivatives
Authors: Ji Cheng‐Long , Lu Yi‐Nan , Xia Siyu , Zhu Chengjian , Zhu Congqing , Li Weipeng , Xie Jin
Published: January 2025

The simple and efficient conversion of carboxylic acids into structurally diverse organic molecules is highly desirable in chemical synthesis. This review covers recent developments in photocatalytic methodology for late‐stage transformations of complex carboxylic acids and their derivatives enabled by radical decarboxylation and deoxygenation, highlighting some representative and significant contributions in this field. These advancements are categorized based on the reactivity patterns exhibited by the carboxylic acids. Several activation modes to generate alkyl or aryl radical intermediates during decarboxylation of carboxylic acids are presented, namely, single‐electron transfer (SET) oxidation, ligand‐to‐metal charge transfer (LMCT), SET reduction, and energy transfer (EnT) processes. On the other hand, direct activation of C−O bonds in carboxylic acids mediated by phosphoranyl radicals has been discussed and illustrates their potential synthetic application for the synthesis of complex aldehydes, ketones and amides.
Aminopeptidase N‐Activated Self‐immolative Hydrogen Sulfide Donor for Inflammatory Response‐Specific Wound Healing
Authors: Rong Fan , Bao Wenxin , Li Guanyi , Ge Yuxuan , Zhu Wangyang , Hao Bin , Zhao Yaxue , Yuan Yunsheng , Wang Yin
Published: January 2025

Hydrogen sulfide (H2S) plays crucial inflammatory modulating roles, representing a promising candidate for anti‐inflammatory therapies. However, current H2S delivery approaches lack sufficient specificity against inflammatory response. Herein, regarding the overexpressed aminopeptidase N (APN) at the inflammation sites, an APN‐activated self‐immolative carbonyl sulfide (COS)/H2S donor (AlaCOS) was developed for inflammatory response‐specific H2S delivery. The compound showed sustained H2S generation upon APN activation in the presence of carbonic anhydrase (CA), and the responsiveness could be well regulated by modulating the amino acid sequence. Due to the inflammatory response‐specific sustained H2S delivery, AlaCOS provided potent anti‐inflammatory capability, which was further validated by RNA sequencing. In vivo experiments on a full‐thickness cutaneous wound murine model also showed the strong promoting effect on wound healing, mainly due to the regulation of the inflammatory response by AlaCOS. By introducing a caged coumarin fluorophore to the molecular architecture, self‐reporting fluorescence could be generated accompanied with APN‐mediated COS/H2S release, which achieved the visualization of H2S delivery in vitro and in vivo. This work not only offers a useful tool for studying the bioactivity of H2S on inflammation, but also provides new insights for developing novel therapies to cope with inflammation‐associated diseases.
Magnetically Driven Self‐Healing Polyurea: Innovative Approaches for Smart Material Design
Authors: Deng Pengcheng , Wan Wenyu , Guo Huangying , Zhang Haonan , Zhou Yucheng , Zhou Xing
Published: January 2025

Polymer materials, commonly used and susceptible to damage from external forces and environmental factors, now have a new intelligent self‐healing variant inspired by living organisms. This material self‐repairs via dynamic covalent bonds and noncovalent interactions, mitigating microdamage risks and enhancing longevity. The self‐healing polyurethane urea based on disulfide bonds was prepared by reacting a prepolymer synthesized from lipoic acid (TA), triethylenetramine (TETA), and polytetrahydrofuran (PTMEG) with isocyanate. Subsequently, nickel powder modified with amino groups on the surface was prepared by the hydrolysis of tetraethyl orthosilicate (TEOS) and modification with 3‐aminopropyltriethoxysilane (APTES), and it was used as a magnetic and conductive filler added to the polyurethane urea to create magnetic self‐healing polyurethane urea composites (MPUU‐MNi). The material self‐repaired at 40◦C for 12 h after damage, with a self‐healing efficiency of 73%. The initial ultimate stress of MPUU‐MNi‐10 was 8.08 MPa, and after repair, the ultimate stress of MPUU‐MNi‐10 recovered to 5.89 MPa. It possesses good magnetic properties, mechanical properties, self‐healing performance, and magnetic driving performance. Engineers can acquire knowledge about the most recent developments in electromagnetic shielding, which they can creatively integrate into their projects. Delving into cutting‐edge materials and production methods could result in significant product innovation, enhancing their company's market edge.
Study on Strain Rate Sensitivity of a Superelastic Porous Foam Material
Authors: Liu Chang , Wang Yuanchao , Liu Jun , Wang Ziyi , Hong Xiaowen , Ni Yiwen , Cheng Chun
Published: January 2025

Superelastic porous foam materials can change from soft to hard when subjected to external impacts. At the same time, they can disperse and absorb energy and delay the impact time, possessing extremely strong impact protection ability. To study the energy absorption characteristics of superelastic foam materials and the strengthening mechanism under high strain rates, compression experiments under different strain rates were carried out using an INSTRON 5966 small universal material testing machine and a Φ16 mm split Hopkinson pressure bar (SHPB) experimental system. The energy absorption efficiency, strain rate sensitivity index, and fracture morphology were analyzed. The results show that under quasi‐static compression, the stress–strain response of superelastic foam has two‐stage characteristics of a slow stress growth region and a rapid stress growth region, and it has an obvious strain rate strengthening effect. Under quasi‐static loading, the material has a relatively high energy absorption efficiency, and the strain rate has little influence on the maximum energy absorption efficiency of the material. Under dynamic loading, the superelastic foam material exhibits strain hardening at high strain rates. As the strain rate increases, its yield strength increases from 7 to 9.9 MPa. The fracture strength increases from 9.97 to 15.65 MPa. Under tensile loading, due to the presence of voids inside the material, the material directly fractures at the end of the elastic stage without a plastic deformation stage.
Use of Digital Health Interventions for Cancer Prevention Among People Living With Disabilities in the United States: A Scoping Review
Authors: Ejezie Chinenye Lynette , Sacca Lea , Ayieko Sylvia , Burgoa Sara , Zerrouki Yasmine , Lobaina Diana , Okwaraji Goodness , Markham Christine
Published: January 2025

Background

The use of digital health strategies for cancer care increased dramatically in the United States over the past 4 years. However, a dearth of knowledge remains about the use of digital health for cancer prevention for some populations with heath disparities. Therefore, the purpose of the present scoping review was to identify digital health interventions for cancer prevention designed for people with disabilities.

Methods

This scoping review was guided by the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for scoping reviews and the Arksey and O'Malley methodological framework. The Embase, PubMed, Ovid MEDLINE, and CINAHL/EBSCO databases were searched for peer‐reviewed articles published from database inception to February 5, 2024. Reports published in English of studies that employed digital health strategies for cancer prevention, were conducted among people with disabilities regardless of age, and were conducted in the United States were included.

Findings

Following screening for eligibility, seven articles were identified. The types of disabilities were cancer (n = 4), bipolar I or II disorder (n = 1), obesity (n = 1), and deafness (n = 1). Interventions focused on education (n = 4), screening (n = 3), smoking cessation (n = 3), physical activity (n = 1), and cessation support (n = 1). Digital health strategies consisted of educational content delivered online, text messaging, interactive educational games, and downloadable informational applications. The common outcome of interest across all manuscripts was intervention efficacy.

Interpretation

Overall, limited research is available to evaluate the use of digital health for cancer prevention among people with disabilities. This review identified gaps in knowledge that, if addressed, may help guide continued innovation in the use of digital health strategies for cancer prevention among people with disabilities.
The Association Between Serum Gamma‐Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systematic Review and Meta‐Analysis
Authors: Ramandi Alireza , George Jacob , Behnoush Amir Hossein , Delavari Alireza , Mohammadi Zahra , Poustchi Hossein , Malekzadeh Reza
Published: January 2025

Background

Gamma‐glutamyl transferase (GGT) has been shown to have associations with several diseases including cancers. Previous studies have investigated the effect of GGT levels on the gastrointestinal (GI) cancer incidence. We aim to systematically investigate these studies to provide better insights into the interrelationship between GGT and GI cancers.

Methods

Online databases were searched to find relevant studies investigating different GGT levels' effects on the incidence of GI cancers including colorectal, esophageal, liver, pancreas, gastric, and biliary duct cancers. Random‐effect meta‐analysis was conducted to pool the hazard ratios (HRs) of GGT quartiles (Qs) effect on cancer incidence.

Results

A total of 26 studies were included in the final review, 12 of which underwent meta‐analysis that investigated 11 million patients. Based on the meta‐analysis, Q4 patients had a 69% higher hazard of GI cancer incidence (HR 1.69, 95% CI 1.41–2.02, p‐value < 0.001). The hazard ratio significance was also similar for Q3 (HR 1.22, 95% CI 1.15–1.30, p‐value < 0.001) and Q2 (HR 1.10, 95% CI 1.05–1.16, p‐value =0.002) of GGT. Colorectal and liver cancers showed a higher hazard ratio among Q2, Q3, and Q4 of GGT compared to Q1. In pancreas and bile duct cancers, only Q4 of GGT had significantly higher HR. Q3 and Q4 of GGT levels had statistically significant associations with gastric cancer incidence.

Conclusion

Higher GGT levels correlate with higher rates of GI cancer incidence, especially in colorectal and hepatic cancers. Future studies should investigate this biomarker's potential role in risk assessment for digestive cancers.
Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma
Authors: Zhu Changyu , Liu Heshu , Li Zhixin , Shi Yijun , Zhao Jingyang , Bai Yuping , Chen Qian , Li Wei
Published: January 2025

Background

This study aims to elucidate the expression pattern of SERPINE1, assess its prognostic significance, and explore potential therapeutic drugs targeting this molecule.

Methods and Results

In this study, we delved into the variations in gene mutation, methylation patterns, and expression levels of SERPINE1 in head and neck squamous cell carcinoma (HNSCC) and normal tissues, leveraging comprehensive analyses of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. The connection between the biological function of the gene and prognosis was scrutinized through immune infiltration and enrichment analyses. Concurrently, we assessed the potential therapeutic value of SERPINE1 through drug sensitivity analysis. It was observed that, particularly in human papillomavirus (HPV) negative HNSCC, SERPINE1 exhibited elevated expression levels, correlating with poorer prognosis. The infiltration levels of eight cell types, such as eosinophils, Tgd, and macrophages, showed a positive correlation with SERPINE1 expression, whereas infiltration levels of four cell types, including cytotoxic cells, B cells, and pDCs, displayed a negative correlation. Furthermore, copy number variations of SERPINE1 were primarily characterized by homologous amplification, positively correlating with its expression, while methylation showed an inverse correlation. The outcomes of drug sensitivity analysis underscored the potential of SERPINE1 as a therapeutic target.

Conclusion

Elevated expression of SERPINE1 in HNSCC is intricately linked with adverse prognostic outcomes and has the potential to influence the immune microenvironment. Subsequent investigations are imperative to fully elucidate the prognostic implications of SERPINE1 as a biomarker and to unlock its therapeutic promise as a target for intervention.
Self‐assembled Palmitic Acid‐modified Thymopentin Functions as a Delivery System of Nanovaccine for Cancer Immunotherapy
Authors: Chen Danhong , Ye Xiaoyun , Xu Ran , Li Wanqiong , Xiao Youmei , Niu Xiaoshuang , Yang Xin , Wang Mengfan , Su Ye , Zeng Wenxuan , Luo Feiyu , Gao Yanfeng
Published: January 2025

In clinical practice, thymopentin (TP‐5) is a commonly utilized immunomodulatory peptide drug. The relatively short half‐life of TP‐5, however, significantly limits its applicability in immunotherapy. Inspired by the structure of the TLR2 ligand lipopeptide Pam3CSK4, fatty acid‐modified TP‐5 peptides were designed and synthesized in this study. Utilizing its amphiphilicity, they were sonicated to assemble into nanoparticles with the diameters of approximately 100 nm. Compared with TP‐5, TP‐5 monopalmitate‐modified nanoparticle has immune‐activating properties both in vivo and in vitro. It markedly increased TNF‐α secretion from RAW264.7 cells and aided in the maturation of DCs. The immunogenicity of OVA model antigen was increased in vivo when capsulated by TP‐5 lipopeptide nanoparticle, which considerably slowed the growth of B16‐OVA melanoma. This fatty acid‐modified TP‐5 assembled nanoparticle offers a straightforward and useful delivery system for the design of innovative nanovaccine for cancer immunotherapy.
A Rare Case of Wolfram Syndrome Presenting With Tuberculous Meningitis: A Case Report
Authors: Khan Nabiha , Ashraf Muhammad Usama , Khan Sadia , Khan Allahdad , Shahzad Humna , Habib Mudasira , Kamal Aseel
Published: January 2025

Wolfram syndrome is an extremely rare condition composed of a tetrad of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. When concurrently presenting with another condition, such as tuberculous meningitis, the widespread range of resulting symptoms delays the establishment of diagnosis and treatment, which results in increased patient morbidity.
Concomitant Pulmonary and Biliary Manifestations of Ulcerative Colitis: A Case Report
Authors: Shrestha Pritee , Shara Philip , Adio Babajide
Published: January 2025

Ulcerative colitis can present with extra‐intestinal manifestations, including interstitial lung disease and primary sclerosing cholangitis. When pulmonary symptoms precede gastrointestinal, diagnosis can be challenging. Consideration of Ulcerative colitis in patients with unexplained lung and hepatic pathology is crucial, as a failure of timely intervention can lead to multiorgan complications.
Quadruple N‐Methylation of Ethylenediamine with CO2 and H2 over Supported Sulfurized Re Catalysts
Authors: Wang Min , Kanemaru Daigo , Yabushita Mizuho , Okuma Kazuki , Shono Tomohiro , Nakagawa Yoshinao , Tomishige Keiichi
Published: January 2025

Sulfurized Re clusters supported on carbon black were demonstrated to exhibit high catalytic activity and stability in the quadruple N‐methylation of ethylenediamine (EDA) using CO2 and H2 as a C1 source and reductant, respectively. EDA underwent the step‐by‐step N‐functionalization consisting of N‐formylation and N‐methylation to be the target product N,N,N′,N′‐tetramethylethylenediamine (TetraM‐EDA), whose maximum yield reached 84% under the optimum conditions. In this reaction, N,N′‐dimethylethylenediamine and its N‐formylated compounds were found as the important intermediates. The ReSx species in the clusters consisting of both metallic and sulfurized Re were assumed from various characterizations and control experiments to exhibit the better activity for the hydrogenation of N‐formylated compounds than the clusters composed of metallic and oxidized Re species, enabling the high‐yielding production of TetraM‐EDA. Another plausible role of sulfurized Re species was assumed to offer high resistance against highly basic N‐methylated EDAs in this reaction. The synergy between metallic and sulfurized Re species is the key to the high activity for the quadruple N‐methylation of EDA.
Novel techniques in bio‐oil production through catalytic pyrolysis of waste biomass: Effective parameters, innovations, and techno‐economic analysis
Authors: Rezvani Behnam
Published: January 2025

The increasing demand for sustainable energy sources has driven significant advancements in the field of bio‐oil production. This article scrutinizes catalytic pyrolysis for its ability to improve bio‐oil characteristics through the use of catalysts and optimization of process conditions. Critical parameters such as reaction temperature, heating rate, biomass feedstock, and catalyst type are analyzed for their influence on bio‐oil properties. Innovations in catalyst design, including the development of hierarchical zeolites, metal oxides, and bifunctional catalysts, are explored for their efficacy in deoxygenation, minimizing coke formation, and stabilizing bio‐oil. Additionally, advanced techniques like catalytic plasma pyrolysis and co‐pyrolysis with diverse feedstocks are investigated to further enhance bio‐oil quality. The techno‐economic analysis is conducted to assess the feasibility of these novel techniques, considering fixed and variable costs, and the market potential of the produced bio‐oil. This analysis aims to provide a holistic perspective on the economic viability and scalability of catalytic pyrolysis for bio‐oil production. This research contributes to the very recent advancement of bio‐oil production technologies, offering insights into optimizing process parameters and catalyst innovations. The findings facilitate more efficient and economically viable bio‐oil production methods, supporting the transition to renewable energy sources.
Photoinduced Metal‐/Additive‐Free Difluoromethylation of N‐Heteroaromatics†
Authors: Zhu Congjun , Shen Yangyang , Guo Tao , Yang Qing , Zhao Dongpu , Yang Huiqing , Xie Jin
Published: January 2025

Comprehensive Summary

Herein, we report a photo‐induced, metal‐/additive‐free protocol for the difluoromethylation of N‐heteroaromatics with [bis(difluoroacetoxy)iodo]benzene as the difluoromethylation reagent. The protocol affords difluoromethylated N‐heteroaromatics in moderate to good yield (up to 91%). The transformation is compatible with a wide range of substrates and has good tolerance towards various functional groups. Moreover, the synthetic value of this method is further demonstrated by applications in gram‐scale synthesis and the late‐stage functionalization of biologically important molecules.
A Phase 1 Randomized Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Escalating Oral Doses of Dordaviprone and the Effects of Food on the Bioavailability of Dordaviprone in Healthy Adult Subjects
Authors: Faison Shamia L. , Batonga Joelle , Arumugham Thangam , Bartkus Angela , Morrison Marion , Mullin Mark J. , Tippin Tim , Naderer Odin
Published: January 2025

Dordaviprone (ONC201) is a novel, small molecule imipridone with antitumor effects in glioma patients. This study evaluated the pharmacokinetics and safety of dordaviprone following single escalating doses (Part A), as a capsule content mixed with applesauce or Gatorade (sports drink) [Part B1]), and with or without food [Part B2]. The most common treatment‐emergent adverse events pooled across study parts (Parts A, B1, and B2) were headache, dizziness, and headache, respectively; all were mild. Systemic dordaviprone exposure increased dose proportionally following administration of 125‐625 mg of dordaviprone. Following dordaviprone capsule contents sprinkled on applesauce or dissolved in sports drink, the geometric mean ratios, and 90% confidence intervals (CIs) of the dordaviprone area under the concentration versus time curve (AUC) fell within the bioequivalence (BE) limits of 80.00%‐125.00%; however, for Cmax the 90% CI lower limit (0.70) fell below BE limits when sprinkled on applesauce. The geometric mean ratios and 90% CIs of dordaviprone administered under fed versus fasted conditions fell within BE limits of 80.00%‐125.00% for the AUC, indicating no food effect on total exposure; however, maximum concentration (Cmax) (90% CI 0.55, 0.67) fell below BE limits.
Poly(Norbornene‐Diphenothiazine) for Electrochemical Capture and Release of Chromium and Arsenic Oxyanions from Water
Authors: Li Chen , Wang Dandong , Zhang Zhengyang , Choi Jae Uk , Huang Jun , Bang Ki‐Taek , Xu Shaopeng , Wang Yanming , Kim Yoonseob
Published: January 2025

Drinking water contamination by heavy metals, particularly chromium and arsenic oxyanions, is a severe challenge threatening humanity's sustainable development. Electrochemically mediated water purification is gaining attention due to its high uptake, rapid kinetics, modularity, and facile regeneration. Here, we designed a composite electrode by combining a redox‐active/Faradaic polymer, poly(norbornene‐diphenothiazine) (PNP2), with carbon nanotubes (CNTs) – PNP2‐CNT. The PNP2‐CNT demonstrated exceptional pseudocapacitance behavior, resulting in significantly accelerated adsorption rates for dichromate (Cr(VI); 0.008 g mg−1 min−1) and arsenite (As(III); 0.03 g mg−1 min−1), surpassing reported materials by a margin of 3–200 times, while demonstrating a high adsorption capacity, 666.3 and 612.4 mg g−1, respectively. Furthermore, it effectively converted As(III) to the less toxic arsenate (As(V)) during adsorption and Cr(VI) to the less toxic chromium (Cr(III)) during desorption. This PNP2‐CNT system also showed significantly lower energy consumption, only 0.17% of the CNT control system. This study demonstrated for the first time the use of PNP2 redox‐active polymers in the separation and conversion process, meeting the six criteria of high uptake, rapid kinetics, selectivity, stability, recyclability, and energy efficiency. This achievement expands the scope of advanced materials that address environmental concerns and make an impact by generating energy‐ and cost‐effective water purification.
Redrawing Köppen‐Geiger classes with microclimate: implications for nature and society
Authors: Klinges David H , Maclean Ilya MD , Scheffers Brett R
Published: January 2025

Scientists have long categorized the planet's climate using the Köppen‐Geiger (KG) classification to research climate‐change impacts, biogeographical realms, agricultural suitability, and conservation. However, global KG maps primarily rely on macroclimate data collected by weather stations, which may not represent microclimatic conditions experienced by most life on Earth. Few studies have explored microclimate at broad scales, largely due to data and computational constraints. Here, we predicted KG classes separately from macroclimate and microclimate for more than 32 million locations across six continents. As compared to macroclimate, microclimate had 14‐fold lower error and reclassified 38% of the total area. Microclimate‐derived KG classes were not only more spatially variable but also encompassed a broader range of latitudes, relative to macroclimate‐derived KG classes. By redrawing the lines of climate classes, our study prompts a reevaluation of the importance of meteorological drivers of ecology across scales, shedding light on how natural, agricultural, and social systems experience and respond to global change.