bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective effect of Idelalisib on carbon tetrachloride‐induced liver fibrosis via microRNA‐124‐3P/phosphatidylinositol‐3‐hydroxykinase signalling pathway
Authors: Li Xiaohe , Li Hailong , Zhang Shanshan , Zhang Ruotong , Li Jinhe , Wei Yiying , Yang Cheng , Zhang Fubo , Zhou Honggang
Published: November 2021

Liver fibrosis is the repair process of abnormal connective tissue hyperplasia after liver damage caused by different causes. Inhibition of PI3K/Akt signalling pathway can reduce the deposition of extracellular matrix, inhibit the proliferation of hepatic stellate cells (HSCs), and promote its apoptosis to achieve the purpose of therapy. This study aimed to investigate the effect of Idelalisib (PI3K inhibitor) on carbon tetrachloride (CCl4)‐induced liver fibrosis in mice. We used CCl4‐induced liver fibrosis mouse model in vivo and TGF‐β1‐stimulated HSCs to evaluate the antifibrosis activity of Idelalisib. In vivo, Idelalisib significantly alleviated CCl4‐induced liver damage, collagen deposition, and hydroxyproline accumulation in mice. Immunohistochemistry and Western blot results showed that Idelalisib could significantly inhibit the expressions of COL1 and α‐SMA in a concentration‐dependent manner. In cell experiments, Idelalisib significantly inhibited the expressions of COL1, SMA, and p‐Smad3 in TGF‐β‐induced HSCs, thereby inhibiting HSC activation. Flow cytometry and Western blot results showed that Idelalisib significantly promoted TGFβ‐induced apoptosis of HSCs after 48 h of administration, but had no significant effect after 24 h. Idelalisib promoted the apoptosis of activated HSCs by inhibiting the PI3K/Akt/FOXO3 signalling pathway. To further explore the mechanism by which Idelalisib inhibited PI3K, we predicted the miRNA targeting PI3K through the database and crossed it with the down‐regulated miRNA reported in liver fibrosis mice in the past five years. Finally, we identified miR‐124‐3p and miR‐143‐3p. We then demonstrated that Idelalisib significantly promoted miR‐124‐3p and miR‐142‐3p in vitro and in vivo. Dual‐luciferase report analysis showed that Idelalisib significantly inhibited luciferase activity but had no significant effect on the luc‐MUT transfection assay. Finally, we demonstrated that Idelalisib reversed the effects of miR‐124‐3p inhibitor on the PI3K/Akt/FOXO3 asterisk pathway and caspase‐3. Idelalisib has potential as a candidate drug for alleviating liver fibrosis.
Comparison of physical and psychosocial function post‐treatment among oral cancer patients with low‐to‐moderate and high nicotine dependence
Authors: Peng Hsi‐Ling , Lee Li‐Yun , Huang Bing‐Shen , Lin Chien‐Yu , Chang Ya‐Lan , Chung Ching‐Fang , Chen Shu‐Ching
Published: November 2021

Purpose

After suddenly stopping smoking after an initial oral cancer (OC) diagnosis, patients may restart smoking and nicotine dependence. This study sought to identify factors associated with high nicotine dependence in OC patients who restarted smoking post‐treatment.

Design

A cross‐sectional study.

Methods

A group of 220 OC patients who restarted smoking post‐treatment were recruited from the outpatient radiation department of a single cancer center in northern Taiwan. Demographic and clinical characteristics were recorded, and patients were assessed for nicotine and smoking dependence, physical activity and function, socio‐emotional function, social support, and depression.

Results

Among patients who restarted smoking after treatment for OC, 75.9% reported low‐to‐moderate dependence on smoking, while 24.1% reported high nicotine dependence. Factors associated with high nicotine dependence included higher incidence of smoking per day, greater dependence on smoking, less physical activity per week, and poorer social–emotional function. Those highly dependent on nicotine were younger, unmarried, had less education, and had begun smoking earlier than those with low‐to‐moderate nicotine dependence.

Conclusions

The amount of smoking per day, greater smoking behavioral dependence, less physical activity per week, and worse social–emotional function affected high nicotine dependence.

Clinical relevance

Smoking cessation training and counseling for OC patients may help them better control their use of tobacco after treatment.
A review of multiunit auctions with homogeneous goods
Authors: Khezr Peyman , Cumpston Anne
Published: November 2021

This article provides a comprehensive survey of the literature on multiunit auctions with multiple homogeneous goods. Despite the importance of multiunit auctions, the research on these auctions attracted substantially less attention than single‐unit auctions. We start by providing a review of the theoretical literature on homogeneous good multiunit auctions where bidders have multiunit demands. The articles are categorized based on their models' assumptions regarding bidders' values and the type of auction. Furthermore, we review the empirical and experimental evidence related to these multiunit auctions to understand the relationship with the theoretical findings.
The Application of 3D Dense Face Alignment in Esthetic Rehabilitation
Authors: Liu Yushu , Chen Duo , Zhang Rui , Cui Xinyue , Zhou Yongsheng
Published: November 2021

This article describes a technique for making an esthetic treatment plan by using a virtual face scan reconstructed from digital photographs through three‐dimensional dense face alignment (3DDFA) and intraoral scans. Portrait photographs were captured with a digital camera and were reconstructed to a virtual 3D face scan by 3DDFA. After scaling the virtual face scan to the correct size, intraoral scans and virtual face scans were aligned to create a 3D view of the patient. A virtual diagnostic waxing was created accordingly. In select cases, this technique can provide 3D esthetic predictions when 3D face imaging devices are not available.
KH domain proteins: Another family of bacterial RNA matchmakers?
Authors: Olejniczak Mikolaj , Jiang Xiaofang , Basczok Maciej M. , Storz Gisela
Published: November 2021

In many bacteria, the stabilities and functions of small regulatory RNAs (sRNAs) that act by base pairing with target RNAs most often are dependent on Hfq or ProQ/FinO‐domain proteins, two classes of RNA chaperone proteins. However, while all bacteria appear to have sRNAs, many have neither Hfq nor ProQ/FinO‐domain proteins raising the question of whether another factor might act as an sRNA chaperone in these organisms. Several recent studies have reported that KH domain proteins, such as KhpA and KhpB, bind sRNAs. Here we describe what is known about the distribution, structures, RNA‐binding properties, and physiologic roles of KhpA and KhpB and discuss evidence for and against these proteins serving as sRNAs chaperones.
Imagining the Unimaginable: Origen’s Two Models of the Trinity
Authors: Maspero Giulio
Published: November 2021

Both the history of the Church and Dogmengeschichte witness to an ambiguity in the reception of Origen’s theology. But the last decades have offered new results, ranging from the discovery of the original Greek text of the homilies on the Psalms to the development of a relational and anti‐reductionist epistemology for the history of dogma. These developments make possible a new picture of the great Alexandrine’s theology more faithful to his intention, which can be grasped only through a prayer‐based approach, as in Sarah Coakley’s and Lorenzo Perrone’s works. Origen’s main concern was to identify the purely spiritual dimension with the Trinity, highlighting how Christian theology differentiates itself with respect to both Stoicism and Gnosticism. This brought Origen to formulate two main models for the Trinity: the triangular one and the linear one. Their interplay shows that it is impossible to divide Christology from Pneumatology, thereby inspiring the first attempts to systematize the doctrine of the triune God towards a relational picture. From this perspective, the fourth‐century criticisms by Athanasius and the Cappadocians of the political theology based on the Arian reading of the monarchy, allegedly according to Origen’s Trinitarian theology, can now be presented as a faithful (relational) development of the Alexandrine’s heritage.
Old‐field restoration improves habitat for ants in a semi‐arid landscape
Authors: Parkhurst Tina , Standish Rachel J. , Andersen Alan N. , Prober Suzanne M.
Published: November 2021

Many old fields are undergoing ecological restoration aiming to return lost biodiversity and ecosystem functions. However, there is scant evidence that this outcome is achieved. Here we investigate the effects of tree planting following cessation of cropping on ant communities. Ants are a dominant faunal group, functionally important for ecosystem recovery and widely used as indicators of ecosystem restoration. Using a space‐for‐time approach, we surveyed eight fallow croplands, 10‐year‐old planted old fields, and reference woodlands in semi‐arid south‐western Australia. We tested the extent ant communities in planted old fields diverged from those of fallow cropland and converged with those of reference woodlands, distinguishing areas under tree canopies and open patches to account for a direct tree effect. We analyzed ant community data at species, genus, and functional‐group levels. Ant species composition in planted old fields substantially converged from fallow croplands toward reference woodlands. Abundance and richness of genera in the tree‐associated functional group Subordinate Camponotini was higher under trees than in open areas in planted old fields and reference woodlands. Unlike in reference woodlands, abundance and richness of Hot Climate Specialists was not higher in open areas than under trees in planted old fields, indicating that planted trees did not yet strongly impact the microclimate beneath them. Although old field restoration had positive effects on ant assemblages, full convergence to reference woodlands had not been achieved after 10 years. This was particularly evident for functional groups. Research on older plantings is needed to test if and when full convergence occurs.
In vitro antibacterial and antibiofilm effects of cold atmospheric microwave plasma against Pseudomonas aeruginosa causing canine skin and ear infections
Authors: Kim Eun‐Joo , Hyun Jae‐Eun , Kang Yeong‐Hun , Baek Seung‐Joon , Hwang Cheol‐Yong
Published: November 2021

Background

Pseudomonas aeruginosa is an opportunist pathogen that causes purulent inflammation in the skin and in the ears of dogs. Among the various virulence factors of P. aeruginosa, biofilms have been reported to result in antibiotic resistance, leading to therapeutic limitations. Cold atmospheric microwave plasma (CAMP) is known to have a high antimicrobial effect, which causes physical cell wall rupture and DNA damage.

Hypothesis/Objectives

The objective of this study was to evaluate the antibacterial and antibiofilm effects of CAMP against planktonic bacteria and the biofilm of P. aeruginosa.

Methods and materials

The antibacterial effect of CAMP against P. aeruginosa ATCC10145 and clinical isolates (n = 30) was evaluated using the colony count method. We also assessed the effect of CAMP on biofilm of P. aeruginosa ATCC strain by the colony count method, water‐soluble tetrazolium salt (WST) assay and confocal laser scanning microscopy (CLSM).

Results

The complete eradication of P. aeruginosa (ATCC strain and clinical isolates) was achieved within 120 s at 50 W, and clinical isolates required 60 s shorter than the ATCC strain for complete eradication at 50 W. We also confirmed the time‐dependent bactericidal effect of CAMP at 50 W against ATCC strain biofilm.

Conclusions and clinical importance

CAMP was effective against both planktonic bacteria and biofilm formation of P. aeruginosa. However, further studies on in vivo efficacy and safety in canine skin and ears are necessary to fully validate its clinical application.
Transient Horner’s syndrome and ipsilateral facial hypopigmentation in an acromelanistic cat
Authors: Lam Andrea T.H. , Kibler Lesli N.
Published: November 2021

Horner’s syndrome (HS) occurs when the sympathetic nerve pathway is disrupted. This case report describes a cat with acromelanism that developed unilateral facial hypopigmentation concurrently with HS after an oesophagostomy tube was placed. Both the hypopigmentation and HS resolved completely following removal of the oesophagostomy tube.
Phylogeography of Agathistoma (Turbinidae, Tegulinae) snails in tropical and southwestern Atlantic
Authors: Dornellas Ana P. , Graboski Roberta , Hellberg Michael E. , Lotufo Tito M. C.
Published: November 2021

The rocky intertidal gastropods Agathistoma viridulum and A. hotessierianum occur from the Caribbean to southern Brazil, with a gap in the equatorial region, giving them an anti‐tropical distribution. We used sequences from mitochondrial genes to elucidate the phylogeography of A. viridulum and A. hotessierianum and to infer their relationships to other species of Agathistoma. For A. hotessierianum, haplotype networks and phylogenetic analyses split samples into two distinct groups: one (A. hotessierianum) in the Caribbean region (Greater and Lesser Antilles; Venezuela: Sucre and Isla Margarita) and a new species that we describe from northeastern Brazil. For A. viridulum, genetic analyses split the samples into three groups (Caribbean, northeastern Brazil and southeastern Brazil), but genetic divergence among these was too low for them to be considered species, and morphological differences were not significant. The mtDNA tree identified two clades of eastern Pacific Agathistoma, but many lower‐level relationships within Agathistoma were not well resolved, suggesting that more complete taxon sampling and additional genetic data will be needed to establish more robust relationships among Tegulinae.
Self-monitoring Intervention of Problem Behavior of Students with ADHD Learning in Regular Classroom in China
Authors: Yin Cui , Xiao Yawen , Fu Wangqian
Published: November 2021

The number of children with attention deficit hyperactivity disorder (ADHD) is increasing in China, whose inattention, disorganization, and impaired hyperactivity cause challenges for their study and teachers’ teaching activities in classroom. The study applied self-monitoring intervention for two children with ADHD learning in a primary school to improve their problem behaviors. We found self-monitoring intervention was likely to reduce their off-task behaviors, even for students with ADHD and ASD. Practical implication of the intervention is discussed in the paper.
Effects of Soaking in Water, Base Oil, Ionic Liquid, and Grease of an Epoxy/UHMWPE/MoS2 Composite on Mechanical and Tribological Properties
Authors: Singh Neha , Sinha Sujeet K.
Published: November 2021

Liquid absorption and tribological studies of epoxy-based composite with ultra-high molecular weight polyethylene and MoS2, sliding against steel, were conducted. Composites, as coating and as a bulk, were soaked in water, base oil, ionic liquid, and lithium-based grease for different intervals of days or months. Liquid weight percent gain was more in polar liquids when compared to non-polar. Coated composite soaked in grease for 10 days showed coefficient of friction of 0.08 with wear life of more than 1 million cycles and wear-rate of 1.7 × 10−8 mm3/N m. Bulk polymer composite soaked in grease for 180 days provided the least coefficient of friction of 0.06 and specific wear-rate of 2.60 × 10−7 mm3/N m.
A new oribatid mite of the genus Pilogalumna Grandjean (Acari: Oribatida: Galumnidae) from northeastern Iran, with updated identification key to known species of the genus
Authors: Akrami Mohammad Ali
Published: November 2021

A new species of oribatid mite of the family Galumnidae is described and illustrated based on adult specimens from soil in Mashhad county, Razavi Khorasan Province, northeastern Iran. Pilogalumna khorasanica sp. nov. is characterised by rounded rostrum; very long interlamellar setae; long, nearly setiform, finely bilaterally barbed bothridial setae; medially interrupted dorsosejugal furrow; elongated porose areas A2, very long and narrow, ribbon shaped A3 and large body size. The new species is most similar morphologically to Pilogalumna crassiclava longiareata (Pérez-Íñigo, 1976), however, differs from it in morphology of bothridial setae and structure of notogastral porose areas, by the presence of longer interlamellar setae and larger body size. An updated identification key to known species of Pilogalumna is presented.
On sound propagation along an infinite rectangular duct-like structure with a finite slot opening and its modelling
Authors: Chu S. H. K. , Tang S. K.
Published: November 2021

The sound propagation across a sound leaking section along an infinite rectangular duct-like structure near to the lower order duct eigenfrequencies is investigated numerically in the present study. The sound leakage is achieved by finite length rectangular slots located at a corner of the duct-like structure cross section. The finite-element simulations are performed, in the first place, to gain insights into the modal development inside the structure. A semi-analytical model, which considers the wavy air motions along the slots with oblique sound radiation patterns, is developed. An empirical framework is also proposed to estimate the complex longitudinal wavenumber along the slot using the numerical results and dimensional analysis. The performance of the proposed semi-analytical model, together with the complex wavenumber prediction framework, is tested using two duct-like structures with different cross section aspect ratios. The results show that the present proposed approach gives predictions close to the finite-element simulations. The deviations are well within engineering tolerance.
Supplemental Material: Geochemical indications for the Paleocene-Eocene Thermal Maximum (PETM) and Eocene Thermal Maximum 2 (ETM-2) hyperthermals in terrestrial sediments of the Canadian Arctic
Authors: Reinhardt L. , al. et
Published: November 2021

Contains figures of most depleted δ13C values of selected early Eocene hyperthermals and age of volcanic ash layer MA-1 with graphical representation of error ranges. Additionally, tables of all δ13C data, organic carbon contents, thicknesses of clastic intervals, and details of U-Pb zircon analyses are provided.
Coleman Automorphisms of Extensions of Finite Characteristically Simple Groups by Some Finite Groups
Authors: Hai Jinke , Zhao Lele
Published: November 2021

Let [Formula: see text] be an extension of a finite characteristically simple group by an abelian group or a finite simple group. It is shown that every Coleman automorphism of [Formula: see text] is an inner automorphism. Interest in such automorphisms arises from the study of the normalizer problem for integral group rings.
Arc-Transitive Graphs of Square-free Order with Valency 11
Authors: Li Guang , Ling Bo , Lu Zaiping
Published: November 2021

In this paper, we present a complete list of connected arc-transitive graphs of square-free order with valency 11. The list includes the complete bipartite graph [Formula: see text], the normal Cayley graphs of dihedral groups and the graphs associated with the simple group [Formula: see text] and [Formula: see text], where [Formula: see text] is a prime.
Complete Cohomology for Extriangulated Categories
Authors: Hu Jiangsheng , Zhang Dongdong , Zhao Tiwei , Zhou Panyue
Published: November 2021

Let [Formula: see text] be an extriangulated category with a proper class [Formula: see text] of [Formula: see text]-triangles. We study complete cohomology of objects in [Formula: see text] by applying [Formula: see text]-projective resolutions and [Formula: see text]-injective coresolutions constructed in [Formula: see text]. Vanishing of complete cohomology detects objects with finite [Formula: see text]-projective dimension and finite [Formula: see text]-injective dimension. As a consequence, we obtain some criteria for the validity of the Wakamatsu tilting conjecture and give a necessary and sufficient condition for a virtually Gorenstein algebra to be Gorenstein. Moreover, we give a general technique for computing complete cohomology of objects with finite [Formula: see text]-[Formula: see text]projective dimension. As an application, the relations between [Formula: see text]-projective dimension and [Formula: see text]-[Formula: see text]projective dimension for objects in [Formula: see text] are given.
Communication—Surprisingly High Fast Charge Volumetric Capacities of Hard Carbon Electrodes in Sodium-Ion Batteries
Authors: Rudola Ashish , Wright Christopher J. , Barker Jerry
Published: November 2021

We show herein that electrode-level effects of commercially-available hard carbon (HC) material, as a function of the HC loading, can have two surprising positive outcomes in sodium-ion (Na-ion) pouch cells. First, a HC electrode’s plating-free volumetric capacity actually increases as its loading (and areal capacity) decreases, and secondly, the plating-free volumetric capacity at sub-30 min charging times for HC as Na-ion anode, can be better vs that of graphite anode in lithium-ion (Li-ion) cells at the electrode-level, and actually be significantly higher than the latter at sub-20 min and sub-15 min charging times, despite HC’s lower density than graphite.
Electrochemiluminescence of Ru(bpy)3
2+ in 1-ethyl-3-methylimidazolium Tetrafluoroborate Salt and Its Application in the Fabrication of Biosensor for Thrombin
Authors: Yue Yang , Xiang Wei , Yuan Yiwei , Dong Yongping , Yue Caibo
Published: November 2021

Electrochemiluminescence (ECL) of needle-like structure Ru(bpy)3
2+ (RuND) was investigated in the room temperature ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate (EMImBF4) medium. The results revealed that strong anodic ECL and moderate cathodic ECL could be obtained in ionic liquid without the need of additional coreactant, which could simplify the process for biosensor fabrication. Several experimental parameters, such as potential range, potential scan direction, and ECL spectrum were studied and the possible ECL mechanisms were proposed. Ferrence exhibited apparent inhibiting effect on ECL signal, based on which a label-free ECL aptasensor was fabricated for the detection of thrombin in EMImBF4. In the range of 1.0 × 10−12 to 1.0 × 10−9 mol l−1, the ECL intensity varied linearly with the logarithmic of thrombin concentration with a detection limit of 0.74 pM. The fabricated ECL sensor showed high sensitivity and good selectivity in the detection of thrombin. The results suggested that ionic liquids are the potential media for the fabrication of ECL sensors.
A Wideband Reflector-Backed Antenna for Applications in GPR
Authors: Raza A. , Lin W. , Ishfaq M. K. , Inam M. , Masud F. , Dahri M. H.
Published: November 2021

A resistively loaded wideband slotted patch antenna with optimized performance on lower frequencies is proposed for ground-penetrating radar (GPR) applications. The proposed design is backed by an optimized reflector composed of a periodic array of square loop elements, which enhances the antenna’s gain and directivity. The antenna shows good radiation characteristics and ease of integration with the GPR systems. The proposed structure features a compact size and wide bandwidth covering from 0.6 to 4.6 GHz. The peak gain of 7 dBi is achieved. The fabricated prototype of the antenna along with an integrated optimized reflective surface has overall dimensions of 18 × 22 × 5 cm3. The measured results validate the antenna’s performance in both free space and sandy medium, which enlighten its use for GPR applications.
Joint Matrix Decomposition-Based Missing Data Completion in Low-Voltage Area
Authors: Wu Haowen , Yang Chen , Xie Wenwang , Zhang Wei
Published: November 2021

In-depth mining and analysis of electricity data in low-voltage area are essential for the further intelligent development of power grids. However, in the actual data collection and measurement of low-voltage area, there will be missing data, and complete electricity data cannot be obtained. To obtain complete power data, this paper proposes a low-voltage station area missing data complement model based on joint matrix decomposition. First, we analyse the characteristics of the low-pressure station data. Then, a model that comprehensively considers the characteristics of the low-voltage station area data is proposed, which includes three parts: the construction of a low-voltage station area data tensor, the joint matrix decomposition, and the completion of the missing data, and it is named LPZ. After that, the CIM learning algorithm proposed in this paper is used to iteratively solve the model to obtain the completed data. Finally, the method proposed in this paper is used to complement the two situations of random loss and all-day loss of real current data in a low-voltage station area and compared with the traditional complement method. The experimental results show that this method is not only effective but also that the completion effect is better than that of other completion methods.
Short-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis
Authors: Nehete Pramod N. , Nehete Bharti P. , Patel Akash G. , Chitta Sriram , Scholtzova Henrieta , Williams Lawrence E.
Published: November 2021

Nonhuman primates are frequently transported to a new location or temporarily relocated within their colony. Both transportation and relocation expose animals to new environments, causing them to undergo a stress response (before adapting). In our NHP colony, the mentioned situations are not infrequent for many reasons, including maintenance. The objective of this study was to determine whether abrupt changes consisting of relocation, housing, separation, and grouping could influence hematological and immunological parameters and thereby functional activity. The current study used squirrel monkeys as a model to investigate the stress-inducing effects of relocation within a facility, while animals acclimated to new situations (physical, housing). A detailed blood analysis revealed significant changes in lymphocytes, triglycerides, total protein, creatinine, and ALT. Flow cytometric analysis of peripheral blood showed reduction in CD3+, CD4+, and CD8+ T cells and monocytes, while B cells and natural killer (NK) cells changed with relocation. Simultaneously, changes in functional activity of immune cells altered proliferative responses and as shown by ELISpot (IFN γ). Though the parameters studied are not affected as severely as those in animals transported by road or air, stress responses induced by intrafacility relocation are significant and worth consideration. Our findings indicate that squirrel monkeys mimic the features seen in humans exposed to social stressors and may serve an important model for understanding the mechanisms of stress-induced immune dysfunction in humans.
Generating Bird’s Eye View from Egocentric RGB Videos
Authors: Jain Vanita , Wu Qiming , Grover Shivam , Sidana Kshitij , Chaudhary Gopal , Myint San Hlaing , Hua Qiaozhi
Published: November 2021

In this paper, we present a method for generating bird’s eye video from egocentric RGB videos. Working with egocentric views is tricky since such the view is highly warped and prone to occlusions. On the other hand, a bird’s eye view has a consistent scaling in at least the two dimensions it shows. Moreover, most of the state‐of‐the‐art systems for tasks such as path prediction are built for bird’s eye views of the subjects. We present a deep learning‐based approach that transfers the egocentric RGB images captured from a dashcam of a car to bird’s eye view. This is a task of view translation, and we perform two experiments. The first one uses an image‐to‐image translation method, and the other uses a video‐to‐video translation. We compare the results of our work with homographic transformation, and our SSIM values are better by a margin of 77% and 14.4%, and the RMSE errors are lower by 40% and 14.6% for image‐to‐image translation and video‐to‐video translation, respectively. We also visually show the efficacy and limitations of each method with helpful insights for future research. Compared to previous works that use homography and LIDAR for 3D point clouds, our work is more generalizable and does not require any expensive equipment.
SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence
Authors: D'Marco Luis , Morillo Valery , Gorriz José Luis , Suarez María K. , Nava Manuel , Ortega Ángel , Parra Heliana , Villasmil Nelson , Rojas-Quintero Joselyn , Bermúdez Valmore
Published: November 2021

Background. Over the last few years, the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) has increased substantially in medical practice due to their documented benefits in cardiorenal and metabolic health. In this sense, and in addition to being used for glycemic control in diabetic patients, these drugs also have other favorable effects such as weight loss and lowering blood pressure, and more recently, they have been shown to have cardio and renoprotective effects with anti-inflammatory properties. Concerning the latter, the individual or associated use of these antihyperglycemic agents has been linked with a decrease in proinflammatory cytokines and with an improvement in the inflammatory profile in chronic endocrine-metabolic diseases. Hence, these drugs have been positioned as first-line therapy in the management of diabetes and its multiple comorbidities, such as obesity, which has been associated with persistent inflammatory states that induce dysfunction of the adipose tissue. Moreover, other frequent comorbidities in long-standing diabetic patients are chronic complications such as diabetic kidney disease, whose progression can be slowed by SGLT2i and/or GLP-1RA. The neuroendocrine and immunometabolism mechanisms underlying adipose tissue inflammation in individuals with diabetes and cardiometabolic and renal diseases are complex and not fully understood. Summary. This review intends to expose the probable molecular mechanisms and compile evidence of the synergistic or additive anti-inflammatory effects of SGLT2i and GLP-1RA and their potential impact on the management of patients with obesity and cardiorenal compromise.
Endoscopic Inferior Meatal Antrostomy for Antrochoanal Polyps: A Long-Term Follow-Up
Authors: Landsberg Roee , Masalha Muhamed , Margulis Ariel , Rosman Yossi , Schneider Shay
Published: November 2021

Background: Endoscopic middle meatal antrostomy (EMMA) is considered the standard approach for surgical management of antrochoanal polyps (ACPs). Recently, an endoscopic inferior meatal antrostomy (EIMA) approach for clearing lesions in the maxillary sinus was described. In this study, we compared the long-term outcome of patients with ACP following surgical treatment using one of these 2 approaches (EIMA or EMMA). Methods: The medical charts of all patients treated for ACPs in our institution between January 1, 2009, and July 1, 2020, were reviewed retrospectively. Patients were invited to complete a long-term follow-up assessment. Results: Thirty-eight patients were included in the study: EIMA was the only procedure performed in 25 patients (66%) and EMMA was the only procedure performed in 7 patients (18%). Both procedures were performed in 6 patients (16%): 2 patients (5%) underwent simultaneous EMMA and EIMA for better access and visualization and 4 patients (10.5%) underwent surgical revision consisting of EIMA secondary to failed EMMA at other institutions. Median follow-up was 44 months (range, 6 months–11 years). No evidence of recurrent ACPs, recirculation, synechiae, nasolacrimal duct injury, or bleeding was observed in any of our patients. Small nonobstructing cysts were observed in 2 patients (8%) following EIMA. Conclusions: EIMA prevents violation of the ostiomeatal complex. It provides access to the anteroinferior aspect of the maxillary sinus and should be considered as an alternative to EMMA in patients with ACPs.
Syndromic Craniosynostosis: Objective and Parent-Reported Outcome Measurements after Cranio-Facial Remodelling Surgeries
Authors: Uppar Alok Mohan , Shukla Dhaval , Nayak Nitish , Rao Girish , Dwarakanath Srinivas
Published: November 2021

Introduction: Syndromic craniosynostosis (SC) is a rare entity compared to the non-syndromic variant. Treatment involves a multidisciplinary approach towards a multitude of problems. Early intervention is known to be better for optimum results. We reviewed outcomes of children with SC who underwent reconstructive cranio-facial surgery. Materials and Methods: A retrospective study was conducted using data from hospital case files and the picture archival communication system. Objective data like the cephalic index (CI), both preoperatively and post-operatively, were compared. Subjective data for the cosmesis outcome – “Sloan and Whitaker outcome class” – following surgery were assessed. Also, parent-reported outcome measurement (PROM) was performed with various parameters to assess quality of life (QOL). Results: We had 21 operated cases of SC, with 19 needing cranio-facial remodelling. The male to female ratio was 11:10. Crouzon’s syndrome was the most common syndromic association followed by Apert’s syndrome. Nineteen patients underwent cranio-facial remodelling surgeries and 2 underwent the ventriculo-peritoneal shunt only – for raised intracranial pressure (ICP). Nine patients underwent cranial remodelling with fronto-orbital advancements, and 3 of these patients also received le-fort’s type 3 osteotomy and advancement later. Ten patients underwent fronto-orbital advancement with parieto-occipital barrel-stave osteotomies. Outcomes: Improvement in the CI was maximum at the 6-month follow-up. Six (37.5%) cases had Sloan class 1 outcome, 9 (56.25%) had class 2 outcomes, and 1 patient had a class 6 outcome. Whitaker cosmesis outcomes – 14 out of 16 cases (87.5%) had Category 1 outcomes. PROM was assessed. All parents reported at least a moderate improvement in cosmesis following surgery. Out of 15 cases, 10 (66%) reported significant improvement, while 4 (26.6%) cases reported moderate improvement with respect to eye and visual problems. Four parents reported snoring as a significant problem even after surgery. Most parents felt that the children were doing well, attending regular school, and social well-being was normal and had an overall good QOL. Conclusions: SC cases may have a multitude of other problems like raised ICP, ophthalmological problems, poor intelligence, and cognition apart from cosmetic concerns. PROMs revealed good outcomes in terms of cosmesis, cognition, and ophthalmological and oral cavity-related problems. Significant improvement in overall QOL was seen in most patients following cranio-facial remodelling surgery.
Differentiation of 2 Obsessive-Compulsive Disorder Subgroups with Regard to Demographic and Phenomenological Characteristics Combining Multiple Correspondence and Latent Class Analysis
Authors: Koumantanou Lia , Kasvikis Yiannis , Giaglis Georgios , Skapinakis Petros , Mavreas Venetsanos
Published: November 2021

Introduction: Classic factor analysis of obsessive-compulsive disorder (OCD) dimensions and attempts to identify valid subgroups have not yet produced definitive conclusions. Objective and Methods: This study aims to examine possible homogeneous subgrouping of demographic and phenomenological characteristics in 134 treatment-seeking OCD patients. A combination of multiple correspondence analysis (MCA) and latent class analysis (LCA) was used. Results: MCA showed 2 distinct subgroups of OCD patients and LCA confirmed this result by a two-class solution. Both analyses demonstrated (a) a clear subgroup of female patients with washing compulsions, obsessions related to contamination, and late age of onset and (b) a subgroup comprised mostly of male patients with earlier onset of OCD, checking rituals, and doubts or aggressive obsessions. Mental, ordering, hoarding compulsions, religious, or sexual obsessions and images appeared exclusively in this subgroup. Conclusions: Using 2 different analytic methods, we confirmed at least 2 subgroups in a clinical sample of Greek OCD patients. Future research combining dimensional and latent approaches could facilitate our understanding of the heterogeneous phenotype of OCD.
Anti-Ma2-Associated Limbic Encephalitis after Termination of Immune Checkpoint Inhibitor Therapy for Malignant Pleural Mesothelioma
Authors: Hashimoto Rei , Tanabe Etsuko , Otsuka Yoshihisa , Yoneda Yukihiro , Kageyama Yasufumi
Published: November 2021

Neurological adverse events of immune checkpoint inhibitor (ICI) therapy mostly develop within 3 months after initiation of ICI treatment. An 82-year-old male with malignant pleural mesothelioma developed anti-Ma2-associated limbic encephalitis at a delay of 18 months after the start of nivolumab therapy (3 months after termination of a 15-month course of ICI treatment). Immunotherapy with steroids and immunoglobulins resulted in moderate neurological improvement. Over the next year, malignant pleural mesothelioma gradually worsened, while the anti-Ma2 antibody test remained positive. Anti-Ma2 paraneoplastic encephalitis may occur after a delay following the discontinuation of ICI therapy.
Usefulness of Carcinoembryonic Antigen Doubling Time in Prognosis Prediction after Curative Resection of Locally Recurrent Rectal Cancer: A Retrospective Study
Authors: Sakamoto Junichi , Ozawa Heita , Nakanishi Hiroki , Fujita Shin
Published: November 2021

Introduction: Given that doubling time is an indicator of tumor growth, we assessed the usefulness of carcinoembryonic antigen doubling time (CEA-DT) in prognosis prediction after curative resection for locally recurrent rectal cancer. Methods: During January 1986–December 2016, 33 patients with locally recurrent rectal cancer who underwent curative resection at our hospital were retrospectively reviewed. The primary endpoint was the 3-year recurrence-free survival (RFS) rate. The Kaplan-Meier method was used to compare RFS rates and evaluate univariate and multivariate analyses for factors associated with oncologic outcomes, including CEA-DT. CEA-DT was classified into 2 groups: the short and long CEA-DT groups. Results: The 3-year overall survival and RFS rates were 62.6% and 42.4%, respectively. In multivariate analyses, CEA-DT was an independent risk factor for poor RFS. The 3-year RFS rate was significantly better in the long CEA-DT group than in the short CEA-DT group (58.8% vs. 25.0%, p = 0.0063). Conclusion: CEA-DT is a useful prognostic factor that can be assessed before surgery for locally recurrent rectal cancer. Long CEA-DT may indicate a favorable prognosis. Contrarily, short CEA-DT is associated with poor prognosis; therefore, further treatment intervention is necessary for patients with short CEA-DT.
Heart Rate Variability during Wake and Sleep in Huntington’s Disease Patients: An Observational, Cross-Sectional, Cohort Study
Authors: Marotta Jessica , Piano Carla , Brunetti Valerio , Genovese Danilo , Bentivoglio Anna Rita , Calabresi Paolo , Cortelli Pietro , Della Marca Giacomo
Published: November 2021

Introduction: Autonomic dysfunction has been reported as one of nonmotor manifestations of both presymptomatic and manifest Huntington’s disease (HD). The aim of our study was to evaluate heart rate variability (HRV) during wake and sleep in a cohort of patients with manifest HD. Methods: Thirty consecutive patients with manifest HD were enrolled, 14 men and 16 women, mean age 57.3 ± 12.2 years. All patients underwent full-night attended video polysomnography. HRV was analyzed during wake, NREM sleep, and REM sleep, in time and frequency domain. Results were compared with a control group of healthy volunteers matched for age and sex. Results: During wake, HD patients presented significantly higher mean heart rate than controls (72.4 ± 9.6 vs. 58.1 ± 7.3 bpm; p < 0.001). During NREM sleep, HD patients showed higher mean heart rate (65.6 ± 11.1 vs. 48.8 ± 4.6 bpm; p < 0.001) and greater low frequency (LF) component of HRV (52.9 ± 22.6 vs. 35.5 ± 17.3 n.u.; p = 0.004). During REM sleep, we observed lower standard deviation of the RR interval in HD subjects (3.4 ± 2.2 vs. 3.7 ± 1.3 ms; p = 0.015). Conclusion: Our results show that HD patients have higher heart rate than controls, during wake and NREM, but not during REM sleep. Among HRV parameters, the most relevant difference regarded the LF component, which reflects, at least partially, the ortho-sympathetic output. Our results confirm the involvement of autonomic nervous system in HD and demonstrate that it is evident during both wake and sleep.
Analysis of Budget Disbursement Budget in The End of 2018 in Bangka Belitung Island Province
Authors: Tri SM Hendarti
Published: November 2021

According to Permendagri No. 13 Year 2006 on the principles of general management of the financial area is the financial area which is managed in an orderly, obedient to the regulatory legislation, effective , efficient , economical, transparent and accountable to pay attention to the principles of fairness, appropriateness and usefulness to society . Regional financial management includes planning, determination, implementation, accountability , as well as guidance and supervision of the management of the regional budget. Due to the buildup of this budget disbursement, the Provincial Government of Bangka Belitung Islands is deemed necessary to conduct an evaluation related to the distribution of the budget. One of the factors causing the budget absorption cannot reach 100% is the auction process, which certainly involves rules and regulations. Another factor that causes low budget absorption is the inability of HR to manage tasks.

From the results of the research that has been done, it can be seen that the accumulation of budget disbursement at the end of 2018 has many negative impacts. One of them is the decline in the Bangka Belitung Islands Province Budget Implementation List (DIPA) for 2019 by 363.3 billion. The decline in DIPA occurred due to the lack of maximum Bangka Belitung Islands Provincial Government in maximizing DIPA revenue the previous year. This indicates the lack of good planning that has been made by the government resulting in budgetary congestion at the end of the year. One strategy to anticipate the low budget absorption is by maximizing the implementation of activities and not piling up activities at the end of the year.

 

Key words: Stacking of budget disbursement, APBN, withdrawal of funds at the end of the year.
The Effect Social Influence on the Interest in Implementation A Regional Financial Management Information System (SIPKD) in Padang City Goverment
Authors: Hayati Melda , Ananda Febryandhie
Published: November 2021

This study aims to examine the effect of a social influence on the interest in implementation a regional financial management information system (SIPKD) in Padang PEMKOT. This study is all regional work units that use the regional financial management information system and is also based on the results of the 80 respondents who used the regional financial manager information system who has worked in the Padang City Hall government. In addition, this study uses research respondents who are distributed directly and uses simple linear regression techniques that aim to test research data with the help of SPSS 25. The study uses the social influence of independent variables and one dependent variable, namely: interest in implementation regional financial management information system. The results showed that social influence has a significant influence on the interest in implementation a regional financial management information system.
Home Movie Menggunakan Plex dan FreeNAS
Authors: Iqbal Muhammad , Kusuma Candra Juni Cahyo
Published: November 2021

Banyak orang yang menonton film lewat dari perangkat keras mereka seperti melalui laptop, komputer ataupun smartphone dengan cara mengunduh ataupun streaming secara langsung. Tetapi banyak orang lebih mengunduh karena dapat ditonton dimanapun dan kapanpun. Tetapi dengan mengunduh mengakibatkan penuhnya storage pada laptop, komputer ataupun smartphone, sehingga diperlukannya penambahan storage. Operasi sistem yang digunakan untuk membuat server storage NAS yaitu FreeNAS yang dikhususkan untuk melayani kebutuhan data peyimpanan melalui jaringan lokal area dengan protokol TCP/IP, Kesimpulan dari artcle ini adalah dapat selesai dikerjakan dengan sesuai dengan penyusun harapkan. Seperti server storage FreeNAS dapat diintegrasikan dengan media server Plex, membuka video pada Plex di perangkat lain, seperti smartphone dan dapat membuka video premium dan non premium pada akun lain.
On Instructional Materials: The Pre-Service Teachers Preferences in Time of Pandemic
Authors: Besa Lynn M. , Parcon Richard E.
Published: November 2021

The outbreak of the Covid-19 pandemic did not only surprise many but also caught most of the academic institutions unprepared. As such, the best option to continue the academic year is to go distance education through flexible learning modes. However, several issues are tied to the implementation of the different modes of learning. To find the most appropriate materials in teaching, this study tried to assess the voice of the learners as one of the considerations in the learning system. Using a descriptive method in which the textual responses from 130 English Major Students were converted to quantitative data to establish patterns and qualitative response analysis to capture the implications of the participants’ responses, the researchers analyzed the proposals of the pre-service teachers and their implications to teaching and learning. Findings reveal that the participants implicitly based their preferences on some considerations. Hence, the diversified instructional materials imply their capability and willingness to use various sources and are in favor of engaging in the hybrid form of instructions. Results also indicate that teachers’ preparations should be parallel to the preferences of the learners to meet the demands of the new normal teaching set up.
The Level of Understanding of Accounting is Seen from the Educational Background and Learning Behavior
Authors: Nuris Dudung Ma’ruf , Handayani Vera
Published: November 2021

This study aims to examine whether there is an influence of educational background and learning behavior on the level of understanding of accounting. Understanding the basic concepts of accounting is the main key to assessing the success of learning in the field of accounting. If it is related to the learning process to gain a good understanding of accounting, then the accounting learning experience of students gained during previous education is very important that can be seen from the background of secondary education. Many factors affect the understanding of a student's accounting in addition to secondary education background factors, namely student learning behavior. Good learning behavior will have an impact on understanding good accounting concepts. This type of research is quantitative explanatory. Data collection tools use questionnaires and settings. Data analysis techniques used descriptive analysis and multiple linear regression analysis. The results showed that there was an influence of educational background on the level of understanding of accounting, and there was an influence of learning behavior on the level of accounting understanding. Accounting understanding is obtained from the interaction of various factors that influence it, both from internal factors and from external factors.