bluuebunny/crossref_metadata_2025 huggingface dataset:
Misdiagnosis of Mullerian agenesis in a patient with 46, XX gonadal dysgenesis: a missed opportunity for prevention of osteoporosis
Authors: Thewjitcharoen Yotsapon , Veerasomboonsin Veekij , Nakasatien Soontaree , Krittiyawong Sirinate , Himathongkam Thep
Published: January 2020

Primary amenorrhea could be caused by disorders of four parts: disorders of the outflow tract, disorders of the ovary, disorders of the anterior pituitary, and disorders of hypothalamus. Delay in diagnosis and hormone substitution therapy causes secondary osteoporosis. Herein, we report a case of a 23-year-old phenotypical female who presented with primary amenorrhea from 46, XX gonadal dysgenesis but had been misdiagnosed as Mayer–Rokitansky–Kuster–Hauser (MRKH) syndrome or Mullerian agenesis. The coexistence of gonadal dysgenesis and MRKH was suspected after laboratory and imaging investigations. However, the vanishing uterus reappeared after 18 months of hormone replacement therapy. Therefore, hormone profiles and karyotype should be thoroughly investigated to distinguish MRKH syndrome from other disorders of sex development (DSD). Double diagnosis of DSD is extremely rare and periodic evaluation should be reassessed. This case highlights the presence of estrogen deficiency state, the uterus may remain invisible until adequate exposure to exogenous estrogen.

Learning points:

An early diagnosis of disorders of sex development (DSD) is extremely important in order to promptly begin treatment, provide emotional support to the patient and reduce the risks of associated complications.

Hormone profiles and karyotype should be investigated in all cases of the presumptive diagnosis of Mayer–Rokitansky–Kuster–Hauser (MRKH) syndrome or Mullerian agenesis.

The association between 46, XX gonadal dysgenesis and Mullerian agenesis has been occasionally reported as a co-incidental event; however, reassessment of the presence of uterus should be done again after administration of exogenous estrogen replacement for at least 6–12 months.

A multidisciplinary approach is necessary for patients presenting with DSD to ensure appropriate treatments and follow-up across the lifespan of individuals with DSD.
Primary aldosteronism in Klinefelter’s syndrome: two cases
Authors: Seki Yasufumi , Morimoto Satoshi , Yoshida Naohiro , Bokuda Kanako , Sasaki Nobukazu , Yatabe Midori , Yatabe Junichi , Watanabe Daisuke , Morita Satoru , Hata Keisuke , Yamamoto Tomoko , Nagashima Yoji , Ichihara Atsuhiro
Published: January 2020

Primary aldosteronism (PA) is more common than expected. Aberrant adrenal expression of luteinizing hormone (LH) receptor in patients with PA has been reported; however, its physiological role on the development of PA is still unknown. Herein, we report two unique cases of PA in patients with untreated Klinefelter’s syndrome, characterized as increased serum LH, suggesting a possible contribution of the syndrome to PA development. Case 1 was a 39-year-old man with obesity and hypertension since his 20s. His plasma aldosterone concentration (PAC) and renin activity (PRA) were 220 pg/mL and 0.4 ng/mL/h, respectively. He was diagnosed as having bilateral PA by confirmatory tests and adrenal venous sampling (AVS). Klinefelter’s syndrome was suspected as he showed gynecomastia and small testes, and it was confirmed on the basis of a low serum total testosterone level (57.3 ng/dL), high serum LH level (50.9 mIU/mL), and chromosome analysis. Case 2 was a 28-year-old man who had untreated Klinefelter’s syndrome diagnosed in his childhood and a 2-year history of hypertension and hypokalemia. PAC and PRA were 247 pg/mL and 0.3 ng/mL/h, respectively. He was diagnosed as having a 10 mm-sized aldosterone-producing adenoma (APA) by AVS. In the APA, immunohistochemical analysis showed co-expression of LH receptor and CYP11B2. Our cases of untreated Klinefelter’s syndrome complicated with PA suggest that increased serum LH levels and adipose tissues, caused by primary hypogonadism, could contribute to PA development. The possible complication of PA in hypertensive patients with Klinefelter’s syndrome should be carefully considered.

Learning points:

The pathogenesis of primary aldosteronism is still unclear.

Expression of luteinizing hormone receptor has been reported in aldosterone-producing adenoma.

Serum luteinizing hormone, which is increased in patients with Klinefelter’s syndrome, might contribute to the development of primary aldosteronism.
Use of late-night salivary cortisol to monitor response to medical treatment in Cushing’s disease
Authors: Newell-Price John , Pivonello Rosario , Tabarin Antoine , Fleseriu Maria , Witek Przemysław , Gadelha Mônica R , Petersenn Stephan , Tauchmanova Libuse , Ravichandran Shoba , Gupta Pritam , Lacroix André , Biller Beverly M K
Published: January 2020

Objective

Monitoring of patients with Cushing’s disease on cortisol-lowering drugs is usually performed with urinary free cortisol (UFC). Late-night salivary cortisol (LNSC) has an established role in screening for hypercortisolism and can help to detect the loss of cortisol circadian rhythm. Less evidence exists regarding the usefulness of LNSC in monitoring pharmacological response in Cushing’s disease.

Design

Exploratory analysis evaluating LNSC during a Phase III study of long-acting pasireotide in Cushing’s disease (clinicaltrials.gov: NCT01374906).

Methods

Mean LNSC (mLNSC) was calculated from two samples, collected on the same days as the first two of three 24-h urine samples (used to calculate mean UFC [mUFC]). Clinical signs of hypercortisolism were evaluated over time.

Results

At baseline, 137 patients had evaluable mLNSC measurements; 91.2% had mLNSC exceeding the upper limit of normal (ULN; 3.2 nmol/L). Of patients with evaluable assessments at month 12 (n = 92), 17.4% had both mLNSC ≤ULN and mUFC ≤ULN; 22.8% had mLNSC ≤ULN, and 45.7% had mUFC ≤ULN. There was high variability in LNSC (intra-patient coefficient of variation (CV): 49.4%) and UFC (intra-patient CV: 39.2%). mLNSC levels decreased over 12 months of treatment and paralleled changes in mUFC. Moderate correlation was seen between mLNSC and mUFC (Spearman’s correlation: ρ = 0.50 [all time points pooled]). Greater improvements in systolic/diastolic blood pressure and weight were seen in patients with both mLNSC ≤ULN and mUFC ≤ULN.

Conclusion

mUFC and mLNSC are complementary measurements for monitoring treatment response in Cushing’s disease, with better clinical outcomes seen for patients in whom both mUFC and mLNSC are controlled.
Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis
Authors: Kallali Wafa , Gray Ewan , Mehdi Muhammad Zain , Lindsay Robert , Metherell Louise A , Buonocore Federica , Suntharalingham Jenifer P , Achermann John C , Donaldson Malcolm
Published: January 2020

Objective

CYP11A1 mutations cause P450 side-chain cleavage (scc) deficiency, a rare form of congenital adrenal hyperplasia with a wide clinical spectrum. We detail the phenotype and evolution in a male sibship identified by HaloPlex targeted capture array.

Family study

The youngest of three brothers from a non-consanguineous Scottish family presented with hyperpigmentation at 3.7 years. Investigation showed grossly impaired glucocorticoid function with ACTH elevation, moderately impaired mineralocorticoid function, and normal external genitalia. The older brothers were found to be pigmented also, with glucocorticoid impairment but normal electrolytes. Linkage studies in 2002 showed that all three brothers had inherited the same critical regions of the maternal X chromosome suggesting an X-linked disorder, but analysis of NR0B1 (DAX-1, adrenal hypoplasia) and ABCD1 (adrenoleukodystrophy) were negative.

In 2016, next-generation sequencing revealed compound heterozygosity for the rs6161 variant in CYP11A1 (c.940G>A, p.Glu314Lys), together with a severely disruptive frameshift mutation (c.790_802del, K264Lfs*5). The brothers were stable on hydrocortisone and fludrocortisone replacement, testicular volumes (15–20 mL), and serum testosterone levels (24.7, 33.3, and 27.2 nmol/L) were normal, but FSH (41.2 µ/L) was elevated in the proband. The latter had undergone left orchidectomy for suspected malignancy at the age of 25 years and was attending a fertility clinic for oligospermia. Initial histology was reported as showing nodular Leydig cell hyperplasia. However, histological review using CD56 staining confirmed testicular adrenal rest cell tumour (TART).

Conclusion

This kinship with partial P450scc deficiency demonstrates the importance of precise diagnosis in primary adrenal insufficiency to ensure appropriate counselling and management, particularly of TART.
High frequency of pathogenic ACAN variants including an intragenic deletion in selected individuals with short stature
Authors: Stavber L , Hovnik T , Kotnik P , Lovrečić L , Kovač J , Tesovnik T , Bertok S , Dovč K , Debeljak M , Battelino T , Avbelj Stefanija M
Published: January 2020

Context

Defining the underlying etiology of idiopathic short stature (ISS) improves the overall management of an individual.

Objective

To assess the frequency of pathogenic ACAN variants in selected individuals.

Design

The single-center cohort study was conducted at a tertiary university children’s hospital. From 51 unrelated patients with ISS, the 16 probands aged between 3 and 18 years (12 females) with advanced bone age and/or autosomal dominant inheritance pattern of short stature were selected for the study. Fifteen family members of ACAN-positive probands were included. Exome sequencing was performed in all probands, and additional copy number variation (CNV) detection was applied in selected probands with a distinct ACAN-associated phenotype.

Results

Systematic phenotyping of the study cohort yielded 37.5% (6/16) ACAN-positive probands, with all novel pathogenic variants, including a 6.082 kb large intragenic deletion, detected by array comparative genomic hybridization (array CGH) and exome data analysis. All variants were co-segregated with short stature phenotype, except in one family member with the intragenic deletion who had an unexpected growth pattern within the normal range (−0.5 SDS). One patient presented with otosclerosis, a sign not previously associated with aggrecanopathy.

Conclusions

ACAN pathogenic variants presented a common cause of familial ISS. The selection criteria used in our study were suggested for a personalized approach to genetic testing of the ACAN gene in clinical practice. Our results expanded the number of pathogenic ACAN variants, including the first intragenic deletion, and suggested CNV evaluation in patients with typical clinical features of aggrecanopathy as reasonable. Intra-familial phenotypic variability in growth patterns should be considered.
Clinicopathological features of colorectal polyps and risk of colorectal cancer in acromegaly
Authors: Ochiai Yorinari , Inoshita Naoko , Iizuka Toshiro , Nishioka Hiroshi , Yamada Shozo , Kitagawa Masanobu , Hoteya Shu
Published: January 2020

Objective

Patients with acromegaly are at increased risk of colorectal polyps. However, their risk of colorectal cancer remains unclear. This study aimed to identify the histopathological features of colorectal polyps in patients with acromegaly and compare their risk of colorectal cancer with that in healthy controls.

Methods

The study participants were 178 patients who underwent Hardy’s operation and perioperative colonoscopy at our hospital between April 2008 and September 2016. For the control group, we randomly selected 356 age- and sex-matched patients who underwent colonoscopy at our hospital during the same period. The incidence, size, location, and histology of the colorectal polyps detected were compared between the groups.

Results

Colorectal polyps were detected in 66.8% of the acromegaly group and 24.2% of the control group (P < 0.001). The average number and size of the polyps were 2.44 and 4.74 mm, respectively, in the acromegaly group and 1.77 and 3.89 mm in the control group (P = 0.001). Polyps in the acromegaly group were more likely to be in the rectosigmoid region (P = 0.006). In the acromegaly group, the frequency of polyps ≥5 mm was 34.3% and that for polyps ≥10 mm was 15.2%; the respective values were 7.6% and 2.2% in the control group (P < 0.001). We found no evidence of between-group histopathological differences in the polyp specimens resected by endoscopy.

Conclusions

Patients with acromegaly are at an increased risk of colorectal polyps, especially in the rectosigmoid region. However, there is no pathological evidence that they are at greater risk of colorectal cancer than the general population.
European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity
Authors: Pasquali R , Casanueva F , Haluzik M , van Hulsteijn L , Ledoux S , Monteiro M P , Salvador J , Santini F , Toplak H , Dekkers O M
Published: January 2020

Obesity is an emerging condition, with a prevalence of ~20%. Although the simple measurement of BMI is likely a simplistic approach to obesity, BMI is easily calculated, and there are currently no data showing that more sophisticated methods are more useful to guide the endocrine work-up in obesity. An increased BMI leads to a number of hormonal changes. Additionally, concomitant hormonal diseases can be present in obesity and have to be properly diagnosed – which in turn might be more difficult due to alterations caused by body fatness itself. The present European Society of Endocrinology Clinical Guideline on the Endocrine Work-up in Obesity acknowledges the increased prevalence of many endocrine conditions in obesity. It is recommended to test all patients with obesity for thyroid function, given the high prevalence of hypothyroidism in obesity. For hypercortisolism, male hypogonadism and female gonadal dysfunction, hormonal testing is only recommended if case of clinical suspicion of an underlying endocrine disorder. The guideline underlines that weight loss in obesity should be emphasized as key to restoration of hormonal imbalances and that treatment and that the effect of treating endocrine disorders on weight loss is only modest.
Characterising hyperinsulinemia-induced insulin resistance in human skeletal muscle cells
Authors: Turner Mark C , Martin Neil R W , Player Darren J , Ferguson Richard A , Wheeler Patrick , Green Charlotte J , Akam Elizabeth C , Lewis Mark P
Published: January 2020

Hyperinsulinaemia potentially contributes to insulin resistance in metabolic tissues, such as skeletal muscle. The purpose of these experiments was to characterise glucose uptake, insulin signalling and relevant gene expression in primary human skeletal muscle-derived cells (HMDCs), in response to prolonged insulin exposure (PIE) as a model of hyperinsulinaemia-induced insulin resistance. Differentiated HMDCs from healthy human donors were cultured with or without insulin (100 nM) for 3 days followed by an acute insulin stimulation. HMDCs exposed to PIE were characterised by impaired insulin-stimulated glucose uptake, blunted IRS-1 phosphorylation (Tyr612) and Akt (Ser473) phosphorylation in response to an acute insulin stimulation. Glucose transporter 1 (GLUT1), but not GLUT4, mRNA and protein increased following PIE. The mRNA expression of metabolic (PDK4) and inflammatory markers (TNF-α) was reduced by PIE but did not change lipid (SREBP1 and CD36) or mitochondrial (UCP3) markers. These experiments provide further characterisation of the effects of PIE as a model of hyperinsulinaemia-induced insulin resistance in HMDCs.
Localization of sperm intracellular Ca2+ keeps fertilizability in the newt vas deferens
Authors: Makino Nanae , Sato Nozomi , Takayama-Watanabe Eriko , Watanabe Akihiko
Published: January 2020

Sperm intracellular Ca2+ is crucial for the induction of sperm-egg interaction, but little is known about the significance of Ca2+ maintenance prior to induction. In sperm of the newt Cynops pyrrhogaster, intracellular Ca2+ is localized to the midpiece during storage in the vas deferens, while extracellular Ca2+ is influxed in modified Steinberg’s salt solution to promote a spontaneous acrosome reaction related to the decline of sperm quality. In the present study, sperm from the vas deferens were loaded with the Ca2+ indicator Fluo8H, and changes in Ca2+ localization in modified Steinberg’s salt solution were examined. Calcium ions expanded from the cytoplasmic area of the midpiece to the entire tail in most sperm during a 1-h incubation and localized to the principal piece in some sperm within 24 h. Similar changes in Ca2+ localization were observed in reconstructed vas deferens solution that included ions and pH at equivalent levels to those in the vas deferens fluid. Sperm with Ca2+ localization in the entire tail or the principal piece weakened or lost responsiveness to sperm motility-initiating substances, which trigger sperm motility for fertilization, but responded to a trigger for acrosome reaction. The change in Ca2+ localization was delayed and transiently reversed by ethylene glycol tetraacetic acid or a mixture of Ca2+ channel blockers including Ni2+ and diltiazem. These results suggest that C. pyrrhogaster sperm localize intracellular Ca2+ to the midpiece through Ca2+ transport in the vas deferens to allow for responses to sperm motility-initiating substances.
Single and combined effects of cisplatin and doxorubicin on the human and mouse ovary in vitro
Authors: Lopes Federica , Liu Jin , Morgan Stephanie , Matthews Rebecca , Nevin Lucy , Anderson Richard A , Spears Norah
Published: January 2020

Chemotherapy drugs are administered to patients using combination regimens, and as such the possibility of multiplicative effects between drugs need to be investigated. This study examines the individual and combined effects of the chemotherapy drugs cisplatin and doxorubicin on the human ovary. Although cisplatin and doxorubicin are known to affect female fertility, there is limited information about their direct effects on the human ovary, and none examining the possibility of combined, multiplicative effects of co-exposure to these drugs. Here, human ovarian biopsies were obtained from 14 women at the time of caesarean section, with 38 mouse ovaries also obtained from neonatal C57Bl/6J mice. Tissue was cultured for 6 days prior to analyses, with chemotherapy drugs added to culture medium on the second day of culture only. Treatment groups of a single (5 μg/mL human; 0.5 μg/mL mouse) or double (10 μg/mL human; 1.0 μg/mL mouse) dose of cisplatin, a single (1 μg/mL human; 0.05 μg/mL mouse) or double (2 μg/mL human; 0.01 μg/mL mouse) dose of doxorubicin or a combination of a single dose of both drugs together were compared to controls without drug exposure. Exposure to cisplatin or doxorubicin significantly decreased follicle health in human and mouse, supporting the suitability of the mouse as a model for the human ovary. There was also a significant reduction of mouse follicle number. Human ovarian stromal tissue exhibited increased apoptosis and decreased cell proliferation. Crucially, there was no evidence indicating the occurrence of multiplicative effects between cisplatin and doxorubicin.
Adiponectin is secreted by theca layer cells isolated from chicken ovarian follicles
Authors: Hadley Jill A , Ocón-Grove Olga , Ramachandran Ramesh
Published: January 2020

Adiponectin, an adipokine hormone, influences glucose utilization, insulin sensitivity and energy homeostasis by signaling through two distinct receptors, ADIPOR1 and ADIPOR2. We previously reported that adiponectin and its receptors are expressed in several organs, including testes in chicken. We report herein that adiponectin gene is expressed exclusively in theca layer while ADIPOR1 and ADIPOR2 genes are expressed in granulosa and theca layers of all preovulatory and prehierarchical follicles of the chicken ovary. Estradiol and/or progesterone treatment of sexually immature chickens significantly altered expression of adiponectin and ADIPOR1 in the ovary. Using anti-chicken adiponectin-, ADIPOR1-, or ADIPOR2- antibodies, adiponectin-immunoreactive (ir) cells were found exclusively in the theca layer, and ADIPOR1-ir and ADIPOR2-ir cells were found both in theca and granulosa layers. Theca layer cells dispersed from preovulatory and prehierarchical follicles were found to synthesize and secrete a 720 kDa heavy molecular weight (HMW) isoform of adiponectin in vitro. Recombinant chicken adiponectin (rcADN) expressed in eukaryotic cells under serum-free conditions comprised primarily of the HMW isoform. Treatment of granulosa cells dispersed from 9 to 12 mm preovulatory follicle and 6 to 8 mm prehierarchical follicle with rcADN or an adiponectin receptor agonist, adipoRon, increased pERK and pACC abundance. In addition, both rcADN and adipoRon were found to significantly decrease the expression of steroidogenic acute regulatory protein gene expression in granulosa cells of preovulatory and prehierarchical follicles. In conclusion, adiponectin secreted by theca cell layer is identical in mass to circulating adiponectin. Systemic and/or theca-derived adiponectin is likely to affect proliferation, metabolism, and steroidogenesis of ovarian follicular cells.
Specialized Terminology in the Video Game Industry: Neologisms and their Translation
Authors: Méndez González Ramón
Published: January 2020

The video game industry is growing at a very fast pace. At present, it is the biggest entertainment industry in the world, selling even more than film and music industries. Newly-developed technologies provide video game creators with the necessary tools to develop more complex game worlds, and user interaction is more important than ever. Each one has its own terminology and complexities, which must be perfectly understood in order to deliver high-quality work. Therefore, translators must be deeply aware of how all these technologies and game worlds work. More importantly, they need to be familiar with the specialized terminology they are going to come across while working in the video game industry. This paper is part of a series of studies where a corpus of 300 games is used to analyze the terminology needs of video game translation and interpreting. Specifically, this paper focuses on the relevance of neologisms—as they are one of the basic traits that define a specialized language—and defines the type of neologisms that can be found when localizing a video game with the overall goal of proving that they are common in the video game industry.
“Wisely, and slow. They stumble that run fast”: Learner-Friendly Shakespeare in an EFL Classroom
Authors: Uchimaru Kohei
Published: January 2020

This paper discusses a learner-friendly and student-centred approach to introducing Shakespeare for less advanced English language learners in the university-level EFL classroom. Shakespeare becomes welcome material when the input is comprehensible and enjoyable. In this light, the teaching should first start with the story rather than the language. After hooking students by recounting stories from Shakespeare, the teacher needs to familiarise them with the authentic language through activities carefully designed to initiate them into the language. In approaching the content of Shakespeare’s plays, the students are asked to relate themselves to the world of Shakespeare through active methods advanced by the RSC and the world that students already know. Raising language awareness in learners rather than being taught the language, the students become less frustrated while learning to appreciate Shakespeare.
Modern, yet “full of forms, figures, shapes, objects”
Authors: Albright Michael Andrew
Published: January 2020

With over four hundred years separating today’s millennials from Shakespeare’s plays, it is little wonder that students and teachers have pegged Elizabethan English as difficult—if not impossible—to understand. Generally, the motivation for students who seek such resources or for teachers who furnish them comes from a shared assumption that Shakespeare’s language is indecipherable to today’s audiences—or, just too difficult to grasp. There are even some students (and, teachers) who operate under the false premise that Shakespeare’s plays are composed in Old English, a language that thrived centuries prior to Shakespeare’s earliest works. To make visible the troubling implications of so-called “modern” or “contemporary” translations of Shakespeare’s works, I will look to Shakespeare’s most academic play, Love’s Labour’s Lost, to propose how today’s students are complicit in dismissing Shakespeare for his words as much as audiences of Shakespeare’s time laughed away Holofernes. In addition to surveying a critical history of supplementary resources designed to ease the burden of Shakespeare’s language, an analysis of Holofernes’ stage presence will offer a natural opportunity to explore what happens if we willingly replace Shakespeare’s English for English that is perceived as easier—or, according to some outlets, even truer. This article sets out to complicate the facility and pervasiveness of such contemporary translations by calling attention to the language lessons Holofernes teaches through his folly, revealing that such work is, “not generous, not gentle, not humble” (Love’s Labour’s V.ii.617).
Perchance to Read: Developing an Augmented Reality Game to Increase Student Engagement with Hamlet
Authors: MISAK JOHN R , LaGrandeur Kevin
Published: January 2020

Hamlet (and similar texts) can be difficult for students to follow initially. Often when students read, they may gloss over the text, missing key contexts. These problems lead to a lack of engagement in the literature classroom. The use of videos can help, but this often deters reading. This dilemma prompted the development of an Augmented Reality (AR) application to enhance Hamlet. By ‘zooming in’ on specific elements of Hamlet—Act I Scenes IV and V (the ghost scenes)— students explore and gain valuable information on the context behind these scenes. Students discover their perspective on a key question in the play; is the ghost real, or is it coinage from Hamlet’s brain? Students can arrive at a more concrete understanding of their own thoughts and take away a better grasp of both the context of the scene and the character of Hamlet through their active participation in the application.
 
Primarily, this article will highlight the dramatic effect student experience, both real and perceived, had on the development and execution of the application. The goal is to convey the pedagogical questions addressed when conceptualizing the application: the desired learning outcomes, the perceived student audience, and the need to connect game actions to the text of the play. It is one thing to speculate what students may want/need in such an environment from an instructor’s perspective. It’s another to analyze student and instructor feedback to help highlight critical areas more effectively. Students not only learn through their actions in the app; they help create the design of the application through their feedback. The article will detail the development of the application through this user input and the impact of praxis on its iteration.
Teaching Shakespeare through Collaborative Writing and Performance in a Norwegian Primary School ESL Classroom: An Interview with Ellen Marie Kvaale
Authors: Brataas Delilah Bermudez
Published: January 2020

This interview outlines the experience of Ellen Marie Kvaale, primary school teacher in Hoberg Primary School, in Stange, Norway. She discusses her innovative three-year project introducing three of William Shakespeare’s plays to 5th, 6th, and 7th -grade ESL students. Her project successfully employed challenging pedagogical methods that resulted in student performances, as well as student publications. The project was designed to develop their written and communicative skills in English with students producing multimodal written texts and collaborating on all levels of scene writing, performance design, and production. Building on her project, Ellen Marie also held workshops at Inland Norway University of Applied Sciences for pre-service teachers in which her primary school students participated. Her experience demonstrates the value and efficacy of using Shakespeare and his texts in ESL Primary School classrooms through active and interactive approaches, including performance, music, and collaborative writing that effectively engaged the four basic language skills.
Multiprofessional team perception of a music therapeutic workshop developed by nurses
Authors: Marques Dionasson Altivo , Alves Marcelo da Silva , Carbogim Fábio da Costa , Vargas Divane de , Paula Graziela Lonardoni de , Almeida Carlos Podalirio Borges de
Published: January 2020

ABSTRACT Objective: To understand the perception of a multiprofessional team regarding the use of music in a therapeutic workshop developed by nurses. Method: Qualitative study, of the exploratory type. Data were collected through semi-structured interviews, with the participation of 13 professionals from a Psychosocial Care Center in a municipality of Minas Gerais’ Zona da Mata, and analyzed according to Michel Maffesoli’s comprehensive sociology approach. Results: The testimonies revealed that the use of music in the nurse’s activities in mental health represents a re-signification of nursing care and favors the user’s subjectivity. Final considerations: This study allowed us to show that nurses need to listen to the music that comes from the heart, from the soul, and to the truths that are not always stated in the scenarios of therapeutic practices with individuals going through psychic suffering. Therefore, the care offered should be centered on the human history, which wants to be unveiled and understood.
“Naquela época não se ouvia falar de desaparecido”: família e maternidade na militância do desaparecimento de pessoas no Brasil
Authors: Leal Eduardo Martinelli
Published: January 2020

Resumo Neste artigo analiso as condições históricas do surgimento da militância a partir da trajetória de três mães engajadas na causa do desaparecimento no Brasil. Através de entrevistas semiestruturadas, de pesquisa bibliográfica e de pesquisa documental no Jornal do Brasil, exploro as condições de possibilidade para a militância de mães que buscam seus familiares desaparecidos no Brasil. Enfatizo como a emergência da militância esteve atrelada à construção de um drama familiar por meio de atores estratégicos fundamentais como os meios de comunicação e outros movimentos associados à denúncia da violência urbana no Rio de Janeiro.
Das memórias de Nise da Silveira no hospital psiquiátrico do Engenho de Dentro
Authors: Magaldi Felipe
Published: January 2020

Resumo Este artigo consiste em um estudo sobre a construção da memória da psiquiatra alagoana Nise da Silveira (1905-1999), conhecida a partir da década de 1940 por sua luta contra intervenções biomédicas consideradas violentas e pela defesa de atividades expressivas (sobretudo pintura e modelagem) como forma de tratamento em saúde mental. Concentra-se aqui em projetos desenvolvidos atualmente no âmbito do Instituto Municipal Nise da Silveira, complexo hospitalar centenário localizado no bairro do Engenho de Dentro, no Rio de Janeiro, com ênfase no Museu de Imagens do Inconsciente, no Hotel da Loucura e seus respectivos líderes. Através de trabalho de campo, aponta-se para uma hierarquia de legitimidade concernente ao contato pessoal com a médica, na qual se inscreve uma tensão entre uma memória oficial e uma memória oficiosa.
O Corpo do Patriarca: uma etnografia do silêncio, da morte e da ausência
Authors: Queiroz Vítor
Published: January 2020

Resumo Este artigo inicia-se com uma descrição, mediada por fontes on-line, do enterro do músico Dorival Caymmi e com o relato de uma visita que fiz ao local de sua morte, um apartamento no Rio de Janeiro. Em seguida, trato de problematizar e complexificar - à luz das noções clássicas de corpo e pessoa, bem como de um aparato conceitual inspirado nas formas de conhecimento do candomblé brasileiro - a figura pública deste artista, ora subdividindo, ora multiplicando-a em entidades analíticas diversas. Apresentadas as personas de Caymmi e o que chamei de temas transversais, um conjunto de imagens criado a partir da sua trajetória, refletirei brevemente sobre uma categoria êmica, indispensável tanto para as religiões afro-brasileiras quanto para o próprio Caymmi: o silêncio. Concluo com algumas considerações a respeito dos constrangimentos necessariamente implicados nas narrativas, nas lembranças e, de um modo geral, nos testemunhos históricos.
Entre el futuro que ya llegó y el pasado que nunca pasó: diplomacias chaqueñas en el antropoceno
Authors: Tola Florencia , Santos Antonela dos , Restrepo Juan Pablo , Lopes Gabriel Rodrigues , Sarra Sonia , Chazal Agustina De , Varela Maximiliano
Published: January 2020

Resumen Desde que Crutzen y Stoermer (2000) propusieron llamar “antropoceno” a la época actual, los debates en torno a dicho término han reverberado. Las filosofías y prácticas indígenas chaqueñas y amazónicas que presentaremos en este artículo traslucen concepciones del desequilibrio climático presente que difieren de las posiciones predominantes en Occidente. Mostraremos que ciertos relatos amerindios se sustentan en nociones de tiempo espiralado, aceptan la latencia de metamorfosis interespecíficas y reparten la agencia entre múltiples seres que deben regenerar entre sí relaciones de cuidado y diplomacia. Indicaremos, también, que las sociedades indígenas han vivido cambios ambientales profundos desde el momento mismo de la conquista de sus territorios y que, en este sentido, la crisis global actual sería parte de un patrón más amplio de cambios con los que ellas ya han venido lidiando. Sostendremos, finalmente, que cosmología y geopolítica son aristas indisociables de un mismo proceso antropocénico.
De venenos, escutas e assombrações: caminhos para etnografar o silêncio
Authors: Nadai Larissa , Cesar Rafael do Nascimento , Veiga Cilmara
Published: January 2020

Resumo Este ensaio bibliográfico busca lançar luz sobre o caráter produtivo do ato de silenciar, bem como daquilo que se torna dizível por meio de outros expedientes que não a palavra proferida - olhares, gestos, pausas. Para tanto, propomos a leitura articulada de três obras: Life and Words, de Veena Das; Bearing Witness, de Fiona Ross; e Haunting the Korean Diaspora, de Grace Cho. Nossa escolha diz respeito à qualidade expressa pelas três etnografias em elevar o silêncio a um patamar heurístico e, com isso, colocar sob rasura as representações do silêncio como reino do incognoscível, da falta ou da ausência de linguagem. Ao recompor tais imagens e figurações, temos por intuito destacar outras modalidades e caminhos para etnografar o silêncio que sirvam de inspiração a pesquisas cujos campos empíricos exijam atenção tanto às palavras ditas quanto aos meandros pelos quais se escolhe ativamente calar.
Saúde bucal na atenção primária à saúde: articulações entre o ensino e a estratégia de saúde da família
Authors: ROSELINO Patrícia Laguna , DAMASCENO Jaqueline Lopes , FIGUEIREDO Glória Lúcia Alves
Published: January 2020

Resumo Introdução A saúde bucal na atenção primária à saúde, com profissionais da Odontologia aptos nesse campo de atuação, tem sido descrita como promissora estratégia para se promover saúde. Objetivo Identificar e descrever as articulações intersetoriais e suas contribuições para a formação do profissional em Odontologia e para a saúde bucal de crianças de um município paulista. Material e método Pesquisa de campo, do tipo transversal, de abordagem mista e de caráter intervencionista. Dados secundários foram obtidos dos prontuários e relatórios de estagiários em Odontologia. Foram realizados atendimentos odontológicos a 455 crianças da rede básica de ensino e oito entrevistas com os familiares das crianças faltosas aos atendimentos. Foi utilizada estatística descritiva, com frequência simples e porcentagem, e Análise de Conteúdo para os dados qualitativos. Resultado Verificou-se que 42% das crianças encontravam-se em situação de alto risco à doença cárie. Os traumas e medos, e o escasso conhecimento de higiene bucal das crianças e dos pais influenciaram negativamente no cuidado com a saúde bucal. No consultório odontológico, as fragilidades apontadas pelos familiares foram o despreparo profissional, que vão desde questões técnicas até formas de abordagem pessoal. Conclusão Conclui-se que a prática na atenção primária à saúde aproximou os universitários da realidade social e ampliou e diversificou os cenários de ensino-aprendizagem com maior tempo para educação em saúde. Contudo, há necessidade de mais pesquisas sobre as experiências curriculares efetivas nessa temática.
THE MEANING OF LABOR ACTIVITIES FOR YOUNG WOMEN WITH BREAST NEOPLASMS
Authors: Magalhães Paola Alexandria Pinto de , Loyola Edilaine Assunção Caetano de , Dupas Giselle , Borges Mariana Lopes , Paterra Tatiana da Silva Vaz , Panobianco Marislei Sanches
Published: January 2020

ABSTRACT Objective: to understand the meaning of work activities for young women with breast cancer. Method: a qualitative study that used as a theoretical framework the Symbolic Interactionism and, as the methodological framework, the Discourse of the Collective Subject. It was developed in a mastology outpatient clinic and a mastectomized rehabilitation center whose data collection took place between February 2014 and January 2015. Twelve women between 18 and 40 years old with up to one year of diagnosis of breast cancer participated, being excluded those with metastasis; interviewed from the guiding question: how is it for you to be young with breast cancer, in relation to work? Thematic content analysis was applied. Results: the following theoretical categories emerged: young women’s feelings about having to stop working due to breast cancer and its treatments; quitting work meant annoyance and discouragement; change in income and collection by herself raised concern about the financial contribution; physical changes changing work activities, meaning limitation and impairment; work as an opportunity to live a better life, as a meaning of freedom; lack of collaboration of colleagues in the work environment whose significance was difficulties in the work environment; solidarity and positivity at work and family support that provided them with encouragement to cope with the disease. Conclusion: it was difficult to experience and accept changes in work activities. The support of family, friends and coworkers was paramount to cope with this process, which should also be taken into account by the health team, especially nursing.
Efeitos da doença e adequação da hemodiálise em pacientes com rigidez arterial
Authors: Carvalho Letícia , Cesarino Claudia Bernardi , Garcia Leiza Franco , Ribeiro Rita Helu , Orlandi Fabiana de Souza , Kusumota Luciana
Published: January 2020

RESUMO Objetivos Analisar a adequação do tratamento hemodialítico em pacientes com rigidez arterial e associar os efeitos da doença renal com os fatores sociodemográficos e clínicos. Método Estudo epidemiológico, transversal realizado com 149 renais crônicos em tratamento de hemodiálise em hospital escola do interior do Estado de São Paulo. Utilizou-se para medida da rigidez arterial o aparelho de Dyna-MAPA®. Foram aplicados os testes de regressão linear multivariada, t Student e o qui-quadrado para os biomarcadores e a ocorrência de rigidez arterial. Resultados A maioria dos pacientes encontrava em idade produtiva, inativa profissionalmente, do sexo masculino, união estável, fazendo restrição hídrica e alimentar, com menos de 48 meses de tratamento dialítico; 36,9% dos pacientes apresentavam rigidez arterial. Os biomarcadores creatinina, ureia e fósforo estavam aumentados; hematócrito e hemoglobina estavam diminuídos, média de peso interdialítico de 2,34 ± 1,4 kg, e a maioria do Kt/V inadequado. Quanto aos efeitos da doença renal observou-se significância estatística com os inscritos na lista de transplantes, maior tempo de tratamento e aumento da creatinina. Conclusão Estes resultados podem proporcionar a diminuição da morbimortalidade cardiovascular nestes pacientes.
O ‘Criador’ e os ‘barcos grandes’: imaginando políticas institucionais pesqueiras e ambientais
Authors: Santos Lucas Lima dos
Published: January 2020

Resumo Cardumes de tainha participam anualmente das paisagens marítimas da vila do Pontal do Leste, ilha do Cardoso, Cananeia, São Paulo. As práticas pesqueiras focadas nesses peixes são costumeiras na vila, mas estão fracassando pela competição com as ‘traineiras’ de diversas localidades da região Sul do Brasil. As traineiras são ‘barcos grandes’ de pesca industrial, com grande poder de pesca. Além das intensas predações dessas embarcações estarem trazendo perturbações nas atividades dos pescadores da vila, e nos processos reprodutivos e de crescimento das próprias tainhas, estão também ocasionando conflitos com os ensinamentos do ‘Criador’ (Deus, no Cristianismo). Enquanto o Criador instrui aos habitantes da vila de que existem limiares de predação para qualquer animal não humano, os barcos grandes, motivados pelo mercado e pelo capital, desrespeitam esses ensinamentos. Um dos objetivos deste artigo é descrever a complexa malha cosmopolítica, analisando algumas controvérsias que emergem dos encontros das tainhas com as traineiras, os pescadores da vila e o Criador. Através desses conflitos, a intenção é, por fim, imaginar formas de construir políticas institucionais pesqueiras e ambientais que coloquem simetricamente os ensinamentos do Criador, os conhecimentos de pescadores da vila e científicos do órgão ambiental local, sem cair em dominações e/ou relativismos.
Amazônia indígena: a floresta como sujeito
Authors: Pardini Patrick
Published: January 2020

Resumo Cultivada, manejada pelos humanos durante milênios, a floresta amazônica alterou-se, tornou-se ‘outra’, sem deixar de ser floresta; manteve a sua autonomia de sujeito – sujeito da sua própria renovação e reprodução. Em outras palavras, a Amazônia tornou-se ‘antropogênica’ – a um só tempo cultural e natural, fruto de uma relação de mão dupla entre sujeitos: o Homem e a Floresta, na qual a ação de um não anula a do outro. Graças à Antropologia, sabemos que as sociedadesindígenas da Amazônia conferem dignidade de pessoa ou sujeito aos não humanos. A relação entre sujeitos (simétrica, de troca e reciprocidade) é uma relação ética e também poética. Por outro lado, o que prevalece na civilização ocidentalé a relação sujeito-objeto (assimétrica, autoritária, de poder e dominação), da qual se origina a Natureza-objeto, em oposição ao Homem-sujeito, único detentor de Cultura. Ora, ‘o outro como objeto’ é a negação do outro e a negaçãoda ética. Nisso reside a alteridade radical dos modos de ser e pensar indígenas com relação ao Ocidente. Essa ‘alteridade indígena’ tem, para nós, valor de tesouro e sabedoria. Há, porém, um Ocidente criança e poeta que se reconhece nospovos indígenas e na sua experiência de mundo.
Ruralidades indígenas na Amazônia colonial
Authors: Chambouleyron Rafael , Arenz Karl Heinz , Melo Vanice Siqueira de
Published: January 2020

Resumo Este artigo tem por tema a questão da terra e os índios na Amazônia, de meados do século XVII a meados do século XVIII. O objetivo é discutir os processos de expropriação ensejados pela conquista europeia, pensados no tempo e no espaço, e refletir como, para além desta perspectiva, é preciso entender de que maneira os índios coloniais buscaram construir espaços de autonomia por meio da agricultura. Trata-se de mostrar que, se a colonização implicou um processo de apagamento dos espaços e das práticas agrícolas indígenas, os índios conseguiram construir novas práticas ou legitimar novos espaços de produção agrícola, no interior do próprio mundo colonial.
Amazônia em pedaços: discursos sobre a divisão do Pará no jornal Correio do Tocantins
Authors: Braga Thais Luciana Correa , Costa Alda Cristina
Published: January 2020

Resumo O artigo objetiva identificar e compreender os discursos sobre a divisão do Pará produzidos pelo Correio do Tocantins, jornal que circula em Marabá, no sudeste paraense, desde 1983. Aqui, discurso é entendido a partir da especificidade do jornalismo, que associa características como objetividade, singularidade, atualidade, autoria e ideologia a um modo de dizerpróprio. Adotou-se a hermenêutica de profundidade como postura teórico-metodológica, bem como se utilizou a noção de macroestruturas e microestruturas, oriunda dos estudos críticos do discurso, como principal técnica de pesquisa. Foram analisadas oito notícias da primeira edição do Correio do Tocantins. As principais conclusões apontam para discursos que valorizam a Serra dos Carajás, em detrimento do rio Tocantins; para o embate entre as elites de Marabá e os governos estadual e federal; e para a perda de importância político-econômica de Marabá para Imperatriz, no Maranhão.
Heterotopias da escrita e deslocamentos do literário
Authors: Oliveira Rejane Pivetta de , Caimi Cláudia Luiza
Published: January 2020

Resumo Neste artigo, propomos uma abordagem da literatura produzida em espaços heterotópicos (Foucault, 2015), onde a palavra surge inesperada. O interesse recai sobre o que desloca a literatura dos espaços instituídos, na perspectiva de uma crítica política, capaz de pôr em questão divisões e hierarquias na ordem do sensível (Rancière, 2009). O universo dessa escrita é examinado a partir da coletânea Exercícios de uma escrita menor: um olhar atelial (Farina, Garavelo e Fonseca, 2014), conjunto de textos produzidos por pacientes do Hospital Psiquiátrico São Pedro, em Porto Alegre.
Racionais MC’s, Marighella e o branqueamento do Brasil
Authors: Dutra Paulo
Published: January 2020

Resumo Neste trabalho são discutidos aspectos que circundam o contexto da produção artística e intelectual de representantes da diáspora africana no Brasil com o objetivo de se enfatizar como tal produção e sua recepção passam por um sistemático processo de deturpação que desemboca em aproximações, análises e conclusões baseadas em pressupostos branqueadores.
Pensar a multiplicidade na hiperconcisão ficcional: o microconto brasileiro contemporâneo (2000-2017)
Authors: Ferreira Ana Sofia Marques Viana
Published: January 2020

Resumo Nascido do modernismo e das vanguardas históricas, o microconto é hoje um dos reflexos literários mais emblemáticos do modo de ser e estar do novo milénio, contando com uma produção bastante significativa na América Latina. Neste trabalho, analisamos o panorama atual do microconto brasileiro, atendendo às suas tendências mais representativas, assim como aos autores e às obras que, nas últimas décadas, consolidaram essas mesmas direções.
Corpo caligráfico, voz: as escritas em performance de Manoel Ricardo de Lima e Sérgio Medeiros
Authors: Malufe Annita Costa
Published: January 2020

Resumo O artigo busca apresentar e comentar obras de dois autores contemporâneos e brasileiros, os poetas e escritores Manoel Ricardo de Lima e Sérgio Medeiros, buscando, através de suas escritas, definir aquilo que poderia ser considerado um traço “performático”, marcante em algumas tendências da literatura de hoje. A principal característica dessas escritas performáticas seria a presença do corpo do próprio escrito e a mescla e indistinção de gêneros artísticos. Para tanto, parte-se do conceito de “performance” de Paul Zumthor, para estendê-lo à leitura crítica de alguns textos dos autores Lima e Medeiros, em diálogo com outros artistas e pensadores do teatro, como Antonin Artaud, Samuel Beckett e Hans-Thies Lehmann.