bluuebunny/crossref_metadata_2025 huggingface dataset:
Low frequency novel interictal EEG biomarker for localizing seizures and predicting outcomes
Authors: Lundstrom Brian Nils , Brinkmann Benjamin H , Worrell Gregory A
Published: October 2021

Localizing hyperexcitable brain tissue to treat focal seizures remains challenging. We want to identify the seizure onset zone from interictal EEG biomarkers. We hypothesize that a combination of interictal EEG biomarkers, including a novel low frequency marker, can predict mesial temporal involvement and can assist in prognosis related to surgical resections. Interictal direct current wide bandwidth invasive EEG recordings from 83 patients implanted with 5111 electrodes were retrospectively studied. Logistic regression was used to classify electrodes and patient outcomes. A feed-forward neural network was implemented to understand putative mechanisms. Interictal infraslow frequency EEG activity was decreased for seizure onset zone electrodes while faster frequencies such as delta (2–4 Hz) and beta-gamma (20–50 Hz) activity were increased. These spectral changes comprised a novel interictal EEG biomarker that was significantly increased for mesial temporal seizure onset zone electrodes compared to non-seizure onset zone electrodes. Interictal EEG biomarkers correctly classified mesial temporal seizure onset zone electrodes with a specificity of 87% and positive predictive value of 80%. These interictal EEG biomarkers also correctly classified patient outcomes after surgical resection with a specificity of 91% and positive predictive value of 87%. Interictal infraslow EEG activity is decreased near the seizure onset zone while higher frequency power is increased, which may suggest distinct underlying physiologic mechanisms. Narrowband interictal EEG power bands provide information about the seizure onset zone and can help predict mesial temporal involvement in seizure onset. Narrowband interictal EEG power bands may be less useful for predictions related to non-mesial temporal electrodes. Together with interictal epileptiform discharges and high-frequency oscillations, these interictal biomarkers may provide prognostic information prior to surgical resection. Computational modelling suggests changes in neural adaptation may be related to the observed low frequency power changes.
Breath Metabolites to Diagnose Infection
Authors: Berna Amalia Z , Odom John Audrey R
Published: October 2021

Background

Starkly highlighted by the current COVID-19 pandemic, infectious diseases continue to have an outsized impact on human health worldwide. Diagnostic testing for infection can be challenging due to resource limitations, time constraints, or shortcomings in the accuracy of existing diagnostics. Rapid, simple diagnostics are highly desirable. There is increasing interest in the development of diagnostics that use exhaled breath analysis as a convenient and safe diagnostic method, as breath sampling is noninvasive, secure, and easy to perform. Volatile organic compounds (VOCs) present in exhaled breath reflect the fingerprint of the underlying metabolic and biophysical processes during disease.

Content

In this review, we overview the major biomarkers present in exhaled breath in infectious diseases. We outline the promising recent advances in breath-based diagnosis of respiratory infections, including those caused by influenza virus, SARS-CoV-2, Mycobacterium tuberculosis, Pseudomonas aeruginosa, and Aspergillus fumigatus. In addition, we review the current landscape of diagnosis of 2 other globally important infections: Helicobacter pylori gastrointestinal infection and malaria.

Characteristic and reproducible breath VOCs are associated with several infectious diseases, suggesting breath analysis as a promising strategy for diagnostic development. Ongoing challenges include poor standardization of breath collection and analysis and lack of validation studies. Further research is required to expand the applicability of breath analysis to clinical settings.
Glycated Albumin for the Diagnosis of Diabetes in US Adults
Authors: Fang Michael , Daya Natalie , Coresh Josef , Christenson Robert H , Selvin Elizabeth
Published: October 2021

Background

There is growing interest in using glycated albumin for the diagnosis of diabetes, especially when standard tests (glucose and hemoglobin A1c [Hb A1c]) are unavailable. However, it is unknown how well glycated albumin identifies diabetes in the general population.

Methods

We measured glycated albumin in stored serum samples from the 1999–2004 National Health and Nutrition Examination Survey. We evaluated the ability of glycated albumin to identify undiagnosed diabetes in US adults aged ≥20 (n = 4785), overall and at thresholds corresponding to clinical cut points for Hb A1c and fasting plasma glucose (FPG). We assessed 4 reference definitions for undiagnosed diabetes: increased FPG (≥126 mg/dL) [≥6.99 mmol/L), increased Hb A1c (≥6.5%), either FPG or Hb A1c increased, or both FPG and Hb A1c increased.

Results

Among US adults, glycated albumin had excellent diagnostic accuracy across all 4 definitions of undiagnosed diabetes, with the area under the receiver operating characteristic curve (AUC) ranging from 0.824 to 0.951. Performance was generally consistent across patient demographic and clinical characteristics. Glycated albumin cut points of 16.5% and 17.8% were equivalent to an FPG of 126 mg/dL (6.99 mmol/L; 97th percentile) and Hb A1c of 6.5% (98th percentile) and had low to moderate sensitivity (0.273 to 0.707) but high specificity (0.980 to 0.992) for detecting undiagnosed diabetes.

Conclusion

The excellent diagnostic performance of glycated albumin to identify diabetes defined by either FPG or Hb A1c suggests that glycated albumin may be useful for identifying adults with undiagnosed diabetes when standard tests are unavailable.
Glycated Albumin and Risk of Mortality in the US Adult Population
Authors: Rooney Mary R , Daya Natalie , Tang Olive , McEvoy John William , Coresh Josef , Christenson Robert H , Selvin Elizabeth
Published: October 2021

Background

Glycated albumin is of growing interest as an alternative biomarker of glycemia. However, the association of glycated albumin with long-term outcomes in the general population is uncharacterized. We evaluated the associations of glycated albumin and hemoglobin A1c (HbA1c) with mortality in US adults.

Methods

We conducted a prospective analysis of 12 915 participants in the National Health and Nutrition Examination Survey 1999–2004. We used Cox regression to characterize associations of glycated albumin and HbA1c with all-cause and cardiovascular mortality through 2014. We categorized glycated albumin based on percentiles corresponding to clinical cut-points for HbA1c. No diagnosed diabetes: <5.0% (<12th percentile), 5.0% to 5.6% (12th–82nd percentile, reference), 5.7% to 6.4% (83rd–97th percentile), and ≥6.5% (≥98th percentile). Diagnosed diabetes: <7.0% (<50th percentile), 7.0% to 8.9% (50th–83rd percentile), and ≥9.0% (≥84th percentile).

Results

Among US adults (mean age 46 years), the prevalence of diagnosed diabetes was 6.8%. Glycated albumin and HbA1c were highly correlated (r = 0.76). Over the median 16.8 years follow-up, there were 2818 deaths (652 cardiovascular). Adults with diagnosed diabetes and glycated albumin ≥84th percentile had the highest risk for all-cause mortality [hazard ratio (HR) 3.96, 95% CI 3.06–5.13] and cardiovascular mortality (HR 6.80, 95% CI 4.20–11.03). HbA1c had associations with all-cause and cardiovascular mortality that were similar to those for glycated albumin.

Conclusions

Among US adults, increased values of glycated albumin and HbA1c were associated with all-cause and cardiovascular mortality, particularly in persons with diagnosed diabetes. Glycated albumin may be a useful alternative test of glycemia.
Superiority of urgent vs early endoscopic hemostasis in patients with upper gastrointestinal bleeding with high-risk stigmata
Authors: Horibe Masayasu , Iwasaki Eisuke , Matsuzaki Juntaro , Bazerbachi Fateh , Kaneko Tetsuji , Minami Kazuhiro , Fukuhara Seiichiro , Masaoka Tatsuhiro , Hosoe Naoki , Ogura Yuki , Namiki Shin , Hosoda Yasuo , Ogata Haruhiko , Kanai Takanori
Published: October 2021

Background

Guidelines recommend that all patients with upper gastrointestinal bleeding (UGIB) undergo endoscopy within 24 h. It is unclear whether a subgroup may benefit from an urgent intervention. We aimed to evaluate the influence of endoscopic hemostasis and urgent endoscopy on mortality in UGIB patients with high-risk stigmata (HRS).

Methods

Consecutive patients with suspected UGIB were enrolled in three Japanese hospitals with a policy to perform endoscopy within 24 h. The primary outcome was 30-day mortality. Endoscopic hemostasis and endoscopy timing (urgent, ≤6 h; early, >6 h) were evaluated in a regression model adjusting for age, systolic pressure, heart rate, hemoglobin, creatinine, and variceal bleeding in multivariate analysis. A propensity score of 1:1 matched sensitivity analysis was also performed.

Results

HRS were present in 886 of 1966 patients, and 35 of 886 (3.95%) patients perished. Median urgent-endoscopy time (n = 769) was 3.0 h (interquartile range [IQR], 2.0–4.0 h) and early endoscopy (n = 117) was 12.0 h (IQR, 8.5–19.0 h). Successful endoscopic hemostasis and urgent endoscopy were significantly associated with reduced mortality in multivariable analysis (odds ratio [OR], 0.22; 95% confidence interval [CI], 0.09–0.52; P = 0.0006, and OR, 0.37; 95% CI, 0.16–0.87; P = 0.023, respectively). In a propensity-score-matched analysis of 115 pairs, adjusted comparisons showed significantly lower mortality of urgent vs early endoscopy (2.61% vs 7.83%, P < 0.001).

Conclusions

A subgroup of UGIB patients, namely those harboring HRS, may benefit from endoscopic hemostasis and urgent endoscopy rather than early endoscopy in reducing mortality. Implementing triage scores that predict the presence of such lesions is important.
Overt and concealed genetic loads revealed by QTL mapping of genotype-dependent viability in the Pacific oysterCrassostrea gigas
Authors: Yin Xiaoshen , Hedgecock Dennis
Published: October 2021

Understanding the genetic bases of inbreeding depression, heterosis, and genetic load is integral to understanding how genetic diversity is maintained in natural populations. The Pacific oyster Crassostrea gigas, like many long-lived plants, has high fecundity and high early mortality (type-III survivorship), manifesting a large, overt, genetic load; the oyster harbors an even greater concealed genetic load revealed by inbreeding. Here, we map viability QTL (vQTL) in six interrelated F2 oyster families, using high-density linkage maps of single nucleotide polymorphisms generated by genotyping-by-sequencing (GBS) methods. Altogether, we detect 70 vQTL and provisionally infer 89 causal mutations, 11 to 20 per family. Genetic mortality caused by independent (unlinked) vQTL ranges from 94.2% to 97.8% across families, consistent with previous reports. High-density maps provide better resolution of genetic mechanisms, however. Models of one causal mutation present in both identical-by-descent (IBD) homozygotes and heterozygotes fit genotype frequencies at 37 vQTL; consistent with the mutation-selection balance theory of genetic load, 20 are highly deleterious, completely recessive mutations and 17 are less deleterious, partially dominant mutations. Another 22 vQTL require pairs of recessive or partially dominant causal mutations, half showing selection against recessive mutations linked in repulsion, producing pseudo-overdominance. Only eight vQTL appear to support the overdominance theory of genetic load, with deficiencies of both IBD homozygotes, but at least four of these are likely caused by pseudo-overdominance. Evidence for epistasis is absent. A high mutation rate, random genetic drift, and pseudo-overdominance may explain both the oyster’s extremely high genetic diversity and a high genetic load maintained primarily by mutation-selection balance.
The Interactive Effects of Education and Social Support on Blood Pressure in African Americans
Authors: Byrd DeAnnah R , Jiang Yanping , Zilioli Samuele , Thorpe Roland J , Lichtenberg Peter A , Whitfield Keith E
Published: October 2021

Background

This study examined whether the effects of received and provided social support on blood pressure (BP) would differ by education.

Methods

Data from 602 African American adults (48–95 years) enrolled in the Baltimore Study of Black Aging—Patterns of Cognitive Aging were analyzed using multiple linear regression.

Results

We found no main effects of received and provided social support on BP. However, a significant moderation effect was observed for systolic BP, such that greater received social support was positively associated with higher systolic BP among individuals with low levels of education, adjusting for age, sex, chronic health conditions, and depressive symptoms.

Conclusions

The findings demonstrate that social support and education have joint effects on BP, which highlights the importance of considering psychosocial determinants of adverse cardiovascular health outcomes that disproportionately affect African Americans.
Growth Hormone Signaling Shapes the Impact of Environmental Temperature on Transcriptomic Profile of Different Adipose Tissue Depots in Male Mice
Authors: Schneider Augusto , Victoria Berta , Schiavon Cousen Maria Isabel , Fang Yimin , McFadden Samuel , Darcy Justin , Gesing Adam , Hascup Erin R , Hascup Kevin N , Bartke Andrzej , Masternak Michal M
Published: October 2021

Growth hormone receptor knockout (GHRKO) mice are smaller, long living, and have an increased metabolic rate compared with normal (N) littermates. However, it is known that thermoneutral conditions (30–32°C) elicit metabolic adaptations in mice, increasing the metabolic rate. Therefore, we hypothesized that environmental temperature would affect the expression profile of different adipose tissue depots in GHRKO mice. For this, N (n = 12) and GHRKO (n = 11) male mice were maintained at 23 or 30°C from weaning until 11 months of age. RNA sequencing from adipose tissue depots (epididymal—eWAT, perirenal—pWAT, subcutaneous—sWAT, and brown fat—BAT) was performed. Thermoneutrality increased body weight gain in GHRKO mice, but not in N mice. Only a few genes were commonly regulated by temperature in N and GHRKO mice. The BAT was the most responsive to changes in temperature in both N and GHRKO mice. BAT Ucp1 and Ucp3 expression were decreased to a similar extent in both N and GHRKO mice under thermoneutrality. In contrast, eWAT was mostly unresponsive to changes in temperature. The response to thermoneutrality in GHRKO mice was most divergent from N mice in sWAT. Relative weight of sWAT was almost 4 times greater in GHRKO mice. Very few genes were regulated in N mice sWAT when compared with GHRKO mice. This suggests that this WAT depot has a central role in the adaptation of GHRKO mice to changes in temperature.
Unobtrusive Sensing Technology Detects Ecologically Valid Spatiotemporal Patterns of Daily Routines Distinctive to Persons With Mild Cognitive Impairment
Authors: Wu Chao-Yi , Dodge Hiroko H , Gothard Sarah , Mattek Nora , Wright Kirsten , Barnes Lisa L , Silbert Lisa C , Lim Miranda M , Kaye Jeffrey A , Beattie Zachary
Published: October 2021

Background

The ability to capture people’s movement throughout their home is a powerful approach to inform spatiotemporal patterns of routines associated with cognitive impairment. The study estimated indoor room activities over 24 hours and investigated relationships between diurnal activity patterns and mild cognitive impairment (MCI).

Methods

One hundred and sixty-one older adults (26 with MCI) living alone (age = 78.9 ± 9.2) were included from 2 study cohorts—the Oregon Center for Aging & Technology and the Minority Aging Research Study. Indoor room activities were measured by the number of trips made to rooms (bathroom, bedroom, kitchen, living room). Trips made to rooms (transitions) were detected using passive infrared motion sensors fixed on the walls for a month. Latent trajectory models were used to identify distinct diurnal patterns of room activities and characteristics associated with each trajectory.

Results

Latent trajectory models identified 2 diurnal patterns of bathroom usage (high and low usage). Participants with MCI were more likely to be in the high bathroom usage group that exhibited more trips to the bathroom than the low-usage group (odds ratio [OR] = 4.1, 95% CI [1.3–13.5], p = .02). For kitchen activity, 2 diurnal patterns were identified (high and low activity). Participants with MCI were more likely to be in the high kitchen activity group that exhibited more transitions to the kitchen throughout the day and night than the low kitchen activity group (OR = 3.2, 95% CI [1.1–9.1], p = .03).

Conclusions

The linkage between bathroom and kitchen activities with MCI may be the result of biological, health, and environmental factors in play. In-home, real-time unobtrusive-sensing offers a novel way of delineating cognitive health with chronologically-ordered movement across indoor locations.
Sweet impersonators: Molecular mimicry of host glycans by bacteria
Authors: de Jong Hanna , Wösten Marc M S M , Wennekes Tom
Published: October 2021

All bacteria display surface-exposed glycans that can play an important role in their interaction with the host and in select cases mimic the glycans found on host cells, an event called molecular or glycan mimicry. In this review, we highlight the key bacteria that display human glycan mimicry and provide an overview of the involved glycan structures. We also discuss the general trends and outstanding questions associated with human glycan mimicry by bacteria. Finally, we provide an overview of several techniques that have emerged from the discipline of chemical glycobiology, which can aid in the study of the composition, variability, interaction and functional role of these mimicking glycans.
Integrating student and teacher insights to a school-based alcohol program through co-design
Authors: Durl James , Dietrich Timo , Williams Ben , Rundle-Thiele Sharyn
Published: October 2021

School-based programs may be more effective when an array of stakeholders, including users, are involved during the relevant stages of program co-creation—specifically during key development stages such as design, implementation and evaluation. How such programs can be operationally co-created and tested is less known and is therefore the purpose of this article. Two sequential co-design phases underpin this study. First, a co-design session with 20 health and physical education (HPE) teachers focussed on reviewing, testing and critically discussing initial prototype online modules for an alcohol education program. Teacher insights were assessed and incorporated, and the updated online modules were tested with secondary school students (n = 120) capturing their experience in a classroom setting. Insights from each group were analysed using thematic analysis. Teachers and students serve important roles in program co-creation. Teachers remain an underutilized stakeholder group whom are however critical in delivering important insights to enhance educational program design. Teachers demanded more relevance to the national curriculum, further alignment with curriculum assessment standards, and age appropriate content. Student feedback focussed largely on realistic content, personalization and gamification elements. This study represents an application of the seven-step co-design process and advances understanding of the ‘fuzzy back-end’ of the process, namely reflecting on feasibility of integrating teacher and student feedback and ideas. More specifically, how these key—yet distinct—stakeholder groups can be involved, and the merits of their involvement are discussed.
The quest for successful Atlantic salmon restoration: perspectives, priorities, and maxims
Authors: Lennox Robert J , Alexandre Carlos M , Almeida Pedro R , Bailey Kevin M , Barlaup Bjørn T , Bøe Kristin , Breukelaar André , Erkinaro Jaakko , Forseth Torbjørn , Gabrielsen Sven-Erik , Halfyard Edmund , Hanssen Erlend M , Karlsson Sten , Koch Stephanie , Koed Anders , Langåker Roy M , Lo Håvard , Lucas Martyn C , Mahlum Shad , Perrier Charles , Pulg Ulrich , Sheehan Timothy , Skoglund Helge , Svenning Martin , Thorstad Eva B , Velle Gaute , Whoriskey Frederick G , Vollset Knut Wiik
Published: October 2021

Atlantic salmon is often a focal species of restoration efforts throughout the north Atlantic and it is therefore an excellent case study for how best to design programmes to address and mitigate threats and correct population declines. This perspective is written to promote the work that has been accomplished towards restoration of Atlantic salmon populations and synthesize how we believe the lessons can be used effectively to support efforts by management agencies to restore populations. We reviewed where restoration is needed for Atlantic salmon, agreed on definitions for three levels of successful restoration, and then applied these criteria to 49 published papers focused on Atlantic salmon restoration. We identified 16 successful examples of restoration among 49 papers reviewed and discussed what interventions led to success versus failure. We then addressed key questions about when hatchery stocking should be used as part of a restoration measure and whether local restoration efforts are enough when these wide-ranging species encounter broad-scale changes in the north Atlantic, specifically related to issues of climate change and to marine survival. We advise to avoid restoration as much as possible by protecting and managing existing populations and when restoration is necessary, problems should be identified and addressed in partnership with river users. With appropriate resources and research to resolve ongoing mysteries, restoration of lost Atlantic salmon populations is absolutely feasible.
A framework for assessing the skill and value of operational recruitment forecasts
Authors: Kiaer Christian , Neuenfeldt Stefan , Payne Mark R
Published: October 2021

Forecasting variation in the recruitment to fish stocks is one of the most challenging and long-running problems in fisheries science and essentially remains unsolved today. Traditionally, recruitment forecasts are developed and evaluated based on explanatory and goodness-of-fit approaches that do not reflect their ability to predict beyond the data on which they were developed. Here, we propose a new generic framework that allows the skill and value of recruitment forecasts to be assessed in a manner that is relevant to their potential use in an operational setting. We assess forecast skill based on predictive power using a retrospective forecasting approach inspired by meteorology, and emphasize the importance of assessing these forecasts relative to a baseline. We quantify the value of these forecasts using an economic cost-loss decision model that is directly relevant to many forecast users. We demonstrate this framework using four stocks of lesser sandeel (Ammodytes marinus) in the North Sea, showing for the first time in an operationally realistic setting that skilful and valuable forecasts are feasible in two of these areas. This result shows the ability to produce valuable short-term recruitment forecasts, and highlights the need to revisit our approach to and understanding of recruitment forecasting.
Breast cancer risk in residents of Belarus exposed to Chernobyl fallout while pregnant or lactating: standardized incidence ratio analysis, 1997 to 2016
Authors: Cahoon Elizabeth K , Preston Dale , Zhang Rui , Vij Vibha , Little Mark P , Mabuchi Kiyohiko , Drozdovitch Vladimir , Chizhov Konstantin , Yauseyenka Vasilina V , Rozhko Alexander V , Velalkin Ilya V
Published: October 2021

Background

Pregnancy and lactation may constitute radiation-sensitive reproductive periods due to rapid cell proliferation and concentration of radioiodine in the lactating breast. However, there are limited epidemiological data among women exposed to radiation during these periods.

Methods

We examined incidence of breast cancer in a cohort of 3214 women who were pregnant and/or lactating within 2 months (26 April to 30 June 1986) of the Chernobyl accident and residing in contaminated regions of Belarus. There were 33 breast cancers identified through linkage with the Belarusian National Cancer Registry. Breast cancer rates among women who were either pregnant and/or lactating were compared with population rates by calculating standardized incidence ratios (SIR) and 95% confidence intervals (CI) adjusting for attained age, oblast, urban/rural residence and calendar year.

Results

Among women who were lactating, we found a greater than 2-fold increased risk of breast cancer compared with the general population, SIR = 2.49 (95% CI: 1.55, 3.75). In contrast, women who were pregnant were not at increased risk (SIR = 0.84 95% CI: 0.46, 1.38). The SIR was highest in women who were exposed at a younger age and at the earliest time period since the accident, though stratified analyses had limited sample sizes.

Conclusions

We found a significantly increased risk of breast cancer among women residing in contaminated areas of Belarus who were lactating at the time of the accident and may have had elevated exposure to radioiodine, when compared with the general population. Studies of breast cancer with individual radiation dose estimates among women exposed during lactation are warranted.
Time Taken to Detect and Respond to Polio Outbreaks in Africa and the Potential Impact of Direct Molecular Detection and Nanopore Sequencing
Authors: Shaw Alexander G , Cooper Laura V , Gumede Nicksy , Bandyopadhyay Ananda S , Grassly Nicholas C , Blake Isobel M
Published: October 2021

Background

Detection of poliovirus outbreaks relies on a complex laboratory algorithm of cell-culture, polymerase chain reaction (PCR), and sequencing to distinguish wild-type and vaccine-derived polioviruses (VDPV) from Sabin-like strains. We investigated the potential for direct molecular detection and nanopore sequencing (DDNS) to accelerate poliovirus detection.

Methods

We analyzed laboratory data for time required to analyze and sequence serotype-2 VDPV (VDPV2) in stool collected from children with acute flaccid paralysis in Africa (May 2016–February 2020). Impact of delayed detection on VDPV2 outbreak size was assessed through negative binomial regression.

Results

VDPV2 confirmation in 525 stools required a median of 49 days from paralysis onset (10th–90th percentile, 29–74), comprising collection and transport (median, 16 days), cell-culture (7 days), intratypic differentiation quantitative reverse transcription PCR (3 days), and sequencing, including shipping if required (15 days). New VDPV2 outbreaks were confirmed a median of 35 days (27–60) after paralysis onset, which we estimate could be reduced to 16 days by DDNS (9–37). Because longer delays in confirmation and response were positively associated with more cases (P < .001), we estimate that DDNS could reduce the number of VDPV2 cases before a response by 28% (95% credible interval, 12%–42%).

Conclusions

DDNS could accelerate poliovirus outbreak response, reducing their size and the cost of eradication.
Sex Differences in How Territory Quality Affects Aggression in Convict Cichlids
Authors: Leese Joseph M , Blatt T
Published: October 2021

Synopsis

In animal contests, the value an individual assigns to limited resources can directly impact the level of aggression it demonstrates. For territorial species, individuals often assess their territory quality and appropriately modify the time and energy invested in its defense. In this study, male and female convict cichlids, Amatitlania nigrofasciata, were acclimated to one of three territorial treatments representing either a low, medium, or high resource value. Territories with a “Low Value” included substrate alone, “Medium Value” territories included substrate and a nest site, and a “High Value” territory included substrate, a nest site, and constant food source. After three days of acclimation, a size-matched intruder was introduced to elicit territorial aggression and behaviors were observed. Territory quality affected one measure of low-intensity aggression (displays) in residents but had no effect on high-intensity aggression (bites and chases). Moreover, there was a significant effect of sex, with males and females differing in the types of aggressive behaviors demonstrated across all treatments. Females showed more low-intensity aggressive behaviors toward intruders than males did. Additionally, a significant interaction of sex and territory quality was observed on two measures of high-intensity aggressive behavior (bites and chases), with females more likely than males to increase aggressive behaviors along with increasing territory quality. This suggests that females may be more sensitive and/or responsive to changes in the quality of a territory, possibly due to the necessity of a suitable nest site for egg deposition within a territory.
Turtling the Salamander: Tail Movements Mitigate Need for Kinematic Limb Changes during Walking in Tiger Salamanders (Ambystoma tigrinum) with Restricted Lateral Movement
Authors: Vega Christine M , Ashley-Ross Miriam A
Published: October 2021

Synopsis

Lateral undulation and trunk flexibility offer performance benefits to maneuverability, stability, and stride length (via speed and distance traveled). These benefits make them key characteristics of the locomotion of tetrapods with sprawling posture, with the exception of turtles. Despite their bony carapace preventing lateral undulations, turtles are able to improve their locomotor performance by increasing stride length via greater limb protraction. The goal of this study was to quantify the effect of reduced lateral flexibility in a generalized sprawling tetrapod, the tiger salamander (Ambystoma tigrinum). We had two potential predictions: (1) either salamanders completely compensate by changing their limb kinematics, or (2) their performance (i.e., speed) will suffer due to the reduced lateral flexibility. This reduction was performed by artificially limiting trunk flexibility by attaching a 2-piece shell around the body between the pectoral and pelvic girdles. Adult tiger salamanders (n = 3; SVL = 9–14.5 cm) walked on a 1-m trackway under three different conditions: unrestricted, flexible shell (Tygon tubing), and rigid shell (PVC tubing). Trials were filmed in a single, dorsal view, and kinematics of entire midline and specific body regions (head, trunk, tail), as well as the fore and hind limbs, were calculated. Tygon individuals had significantly higher curvature than both PVC and unrestricted individuals for the body, but this trend was primarily driven by changes in tail movements. PVC individuals had significantly lower curvature in the trunk region compared with unrestricted individuals or Tygon; however, there was no difference between unrestricted and Tygon individuals suggesting the shells performed as expected. PVC and Tygon individuals had significantly higher curvature in the tails compared with unrestricted individuals. There were no significant differences for any limb kinematic variables among treatments including average, minimum, and maximum angles. Thus, salamanders respond to decreased lateral movement in their trunk by increasing movements in their tail, without changes in limb kinematics. These results suggest that tail undulations may be a more critical component to sprawling-postured tetrapod locomotion than previously recognized.
Overcoming technical and cultural challenges to delivering equitable care for LGBTQ+ individuals in a rural, underserved area
Authors: Marney Heather L , Vawdrey David K , Warsame Leyla , Tavares Spencer , Shapiro Andrea , Breese Arthur , Brayford Amy , Chittalia Aliasgar Z
Published: October 2021

The lesbian, gay, bisexual, transgender, queer, or questioning (LGBTQ+) community is vulnerable to health-care disparities. Many health-care organizations are working to collect sexual orientation and gender identity in their electronic health records (EHRs), with the goal of providing more inclusive care to their LGBTQ+ patients. There are significant human and technical barriers to making these efforts successful. Based on our 5-year experience at Geisinger (an integrated health system located in a rural, generally conservative area), this case report provides insights to overcome challenges in 4 critical areas: (1) enabling the EHR to collect and use information to support the health-care needs of LGBTQ+ patients, (2) building a culture of awareness and caring, empowering members of the health-care team to break down barriers of misunderstanding and mistrust, (3) developing services to support the needs of LGBTQ+ patients, and (4) partnering with local communities to become a trusted health-care provider.
A systematic review on natural language processing systems for eligibility prescreening in clinical research
Authors: Idnay Betina , Dreisbach Caitlin , Weng Chunhua , Schnall Rebecca
Published: October 2021

Objective

We conducted a systematic review to assess the effect of natural language processing (NLP) systems in improving the accuracy and efficiency of eligibility prescreening during the clinical research recruitment process.

Materials and Methods

Guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards of quality for reporting systematic reviews, a protocol for study eligibility was developed a priori and registered in the PROSPERO database. Using predetermined inclusion criteria, studies published from database inception through February 2021 were identified from 5 databases. The Joanna Briggs Institute Critical Appraisal Checklist for Quasi-experimental Studies was adapted to determine the study quality and the risk of bias of the included articles.

Results

Eleven studies representing 8 unique NLP systems met the inclusion criteria. These studies demonstrated moderate study quality and exhibited heterogeneity in the study design, setting, and intervention type. All 11 studies evaluated the NLP system’s performance for identifying eligible participants; 7 studies evaluated the system’s impact on time efficiency; 4 studies evaluated the system’s impact on workload; and 2 studies evaluated the system’s impact on recruitment.

Discussion

NLP systems in clinical research eligibility prescreening are an understudied but promising field that requires further research to assess its impact on real-world adoption. Future studies should be centered on continuing to develop and evaluate relevant NLP systems to improve enrollment into clinical studies.

Conclusion

Understanding the role of NLP systems in improving eligibility prescreening is critical to the advancement of clinical research recruitment.
Sublethal Effects of Abamectin on the Development, Reproduction, Detoxification Enzyme Activity, and Related Gene Expression of the Oriental Fruit Moth (Lepidoptera: Tortricidae)
Authors: Su Sha , Jian Chengzhi , Zhang Xiaohe , Fang Sensen , Peng Xiong , Piñero Jaime C , Chen Maohua
Published: October 2021

Grapholita molesta is one of the most important fruit pests worldwide. Abamectin is a biological pesticide frequently used to control fruit borers like G. molesta in part owing to its translaminar properties. In this study, we characterized the toxicity of abamectin to G. molesta larvae using the diet incorporation method. The sublethal effects of abamectin on the development, reproduction, detoxification enzyme activity, and related gene expression of G. molesta were assessed. The results showed that the LC20 and LC50 values of the insecticide against G. molesta 72 h post-treatment were 1.17 mg L–1 and 5.85 mg L–1, whereas the LC20 and LC50 values 96 h post-treatment were 0.34 mg L–1 and 3.63 mg L–1. When compared to the control, sublethal concentrations of abamectin 1) significantly increased the mortality of the larvae, prepupae, and pupae of G. molesta, 2) prolonged the duration of 3rd to 5th instar larva, prepupal and pupal periods, 3) shortened the longevity of adults, and 4) reduced female fecundity. The enzymatic activity of glutathione S-transferase (GST) varied significantly after exposure to sublethal concentrations of abamectin, but the cytochrome P450 monooxygenases and carboxylesterase activity were not significantly affected. Thirteen of the 25 GST genes were significantly upregulated under different sublethal concentrations of abamectin. The combined findings increase our understanding of the effects of abamectin on G. molesta and the potential role of GSTs in the metabolic interactions of abamectin in this pest, and have applications for more rational and effective use of abamectin to control G. molesta.
Endovascular treatment of a large saccular aneurysm of the celiac artery: a case report and review of literature
Authors: Salimi Javad , Mangouri Amir , Baradaran Ali Farahanchi
Published: October 2021

Celiac artery is a visceral abdominal vasculature whose aneurysms are very rare, accounting for less than 0.01% of all aneurysms. This condition can be treated by open aneurysmectomy or aneurysmorrhaphy and endovascular intervention. Due to the high mortality and morbidity associated with open surgery, endovascular intervention may be a better treatment option. Here, we present a case related to a 40-year-old man who had been experiencing vague epigastric pain for 4 months prior to admission and was managed endovascularly.
IgM Warm Autoantibodies Causing Autoimmune Hemolytic Anemia in a Pediatric Patient
Authors: Fortes Precious , Baez Janet , McGonigle Andrea M , Ziman Alyssa , Federman Noah , Ward Dawn C
Published: October 2021

Most often, IgM-mediated autoimmune hemolytic anemia (AIHA) presents as cold agglutinin disease in the pediatric population. The IgM warm agglutinins are rare, with few reports in the literature. This case study describes a 5 year old girl with nausea, abdominal pain and jaundice, and a hemoglobin of 5.5 g/dL who was diagnosed with a warm reactive IgM AIHA. The laboratory workup revealed a pan-reactive antibody and a direct antiglobulin test negative for IgG and C3. A thermal amplitude assay revealed reactive IgM antibodies at 37°C, 30°C, 25°C, and 4°C and an antibody titer of 1:8. An adsorption for IgM-specific autoantibodies exposed underlying anti-E and anti-Cw alloantibodies. Transfusion of phenotypically matched red blood cell units supported ongoing hemolysis. The AIHA treatment included steroids followed by rituximab with complete resolution. A literature review shows variable outcomes for warm AIHA in the pediatric population and often describes the presence of warm reactive IgM-mediated AIHA as an indicator for poor prognosis.
Chest Pain in the Deployed Setting: A Case of Wellens Syndrome
Authors: Mozeleski Eric M , Callahan Travis A , Vande Hei Anthony G
Published: October 2021

Managing patients with chest pain in deployed and austere environments can be extremely challenging for military health care providers. Limited resources, including access to equipment, emergent cardiac catheterization, and cardiac surgery, can lead to deleterious consequences, including myonecrosis and possible death. Wellens syndrome is a form of acute coronary syndrome that involves stenosis of the left anterior descending coronary artery, leading to possible acute myocardial infarction. Most cases in the literature involve the diagnosis and treatment of Wellens syndrome in the civilian, nondeployed hospital setting. We present a case of a civilian contractor who had experienced an episode of chest pain that had resolved with rest and now had new findings on electrocardiogram concerning Wellens syndrome.
Effect of tides on the orbital evolution of the redback system PSR 1723–2837
Authors: Novarino M L , Echeveste M , Benvenuto O G , De Vito M A , Ferrero G A
Published: October 2021

The standard model of stellar evolution in close binary systems assumes that during mass transfer episodes, the system is in a synchronized and circularized state. Remarkably, the redback system PSR J1723–2837 has an orbital period derivative $\dot{P}_{\rm orb}$ too large to be explained by this model. Motivated by this fact, we investigate the action of tidal forces in between two consecutive mass transfer episodes for a system under irradiation feedback, which is a plausible progenitor for PSR J1723–2837. We base our analysis on Hut’s treatment of equilibrium tidal evolution, generalized by considering the donor as a two layers object that may not rotate as a rigid body. We also analyse three different relations for the viscosity with the tidal forcing frequency. We found that the large value measured for $\dot{P}_{\rm orb}$ can be reached by systems where the donor star rotates slower (by few per cent) than the orbit just after mass transfer episodes. Van Staden & Antoniadis have observed this object and reported a lack of synchronism, opposite to that required by the Hut’s theory to account for the observed $\dot{P}_{\rm orb}$. Motivated by this discrepancy, we analyse photometric data obtained by the spacecraft Kepler second mission K2, with the purpose of identifying the periods present in PSR J1723–2837. We notice several periods close to those of the orbit and the rotation. The obtained periods pattern reveals the presence of a more complex phenomenology, which would not be well described in the frame of the weak friction model of equilibrium tides.
Gravitational lensing of gravitational waves: effect of microlens population in lensing galaxies
Authors: Mishra Anuj , Meena Ashish Kumar , More Anupreeta , Bose Sukanta , Bagla Jasjeet Singh
Published: October 2021

With increasing sensitivities of the current ground-based gravitational wave (GW) detectors, the prospects of detecting a strongly lensed GW signal are going to be high in the coming years. When such a signal passes through an intervening lensing galaxy or galaxy cluster, the embedded stellar mass microlenses lead to interference patterns in the signal that may leave observable signatures. In this work, we present an extensive study of these wave effects in the Laser Interferometer Gravitational Wave Observatory/Virgo frequency band (10–104 Hz) due to the presence of the microlens population in galaxy scale lenses for the first time. We consider a wide range of strong lensing (macro) magnifications and the corresponding surface microlens densities found in lensing galaxies and use them to generate realizations of the amplification factor. The methodologies for simulating amplification curves for both types of images (minima and saddle points) are also discussed. We then study how microlensing is broadly affected by the parameters like macro-magnifications, stellar densities, the initial mass function, types of images, and microlens distribution around the source. In general, with increasing macro-magnification values, the effects of microlensing become increasingly significant regardless of other parameters. Mismatch analysis between the lensed and the unlensed GW waveforms from chirping binaries suggests that, while inferring the source parameters, microlensing cannot be neglected for macro-magnification ≳15. Furthermore, for extremely high macro-magnifications ≳100, the mismatch can even exceed $5{{\ \rm per\ cent}}$, which can result in both a missed detection and, consequently, a missed lensed signal.
The dispersal of protoplanetary discs – III. Influence of stellar mass on disc photoevaporation
Authors: Picogna Giovanni , Ercolano Barbara , Espaillat Catherine C
Published: October 2021

The strong X-ray irradiation from young solar-type stars may play a crucial role in the thermodynamics and chemistry of circumstellar discs, driving their evolution in the last stages of disc dispersal as well as shaping the atmospheres of newborn planets. In this paper, we study the influence of stellar mass on circumstellar disc mass-loss rates due to X-ray irradiation, extending our previous study of the mass-loss rate’s dependence on the X-ray luminosity and spectrum hardness. We focus on stars with masses between 0.1 and 1 M⊙, which are the main target of current and future missions to find potentially habitable planets. We find a linear relationship between the mass-loss rates and the stellar masses when changing the X-ray luminosity accordingly with the stellar mass. This linear increase is observed also when the X-ray luminosity is kept fixed because of the lower disc aspect ratio which allows the X-ray irradiation to reach larger radii. We provide new analytical relations for the mass-loss rates and profiles of photoevaporative winds as a function of the stellar mass that can be used in disc and planet population synthesis models. Our photoevaporative models correctly predict the observed trend of inner-disc lifetime as a function of stellar mass with an increased steepness for stars smaller than 0.3 M⊙, indicating that X-ray photoevaporation is a good candidate to explain the observed disc dispersal process.
Photoevaporation versus core-powered mass-loss: model comparison with the 3D radius gap
Authors: Rogers James G , Gupta Akash , Owen James E , Schlichting Hilke E
Published: October 2021

The extreme ultraviolet (EUV)/X-ray photoevaporation and core-powered mass-loss models are both capable of reproducing the bimodality in the sizes of small, close-in exoplanets observed by the Kepler space mission, often referred to as the ‘radius gap’. However, it is unclear which of these two mechanisms dominates the atmospheric mass-loss that is likely sculpting the radius gap. In this work, we propose a new method of differentiating between the two models, which relies on analysing the radius gap in 3D parameter space. Using models for both mechanisms, and by performing synthetic transit surveys we predict the size and characteristics of a survey capable of discriminating between the two models. We find that a survey of ≳5000 planets, with a wide range in stellar mass and measurement uncertainties at a ${\lesssim}5{{\ \rm per\ cent}}$ level is sufficient. Our methodology is robust against moderate false positive contamination of ${\lesssim}10{{\ \rm per\ cent}}$. We perform our analysis on two surveys (which do not satisfy our requirements): the California-KeplerSurvey and the Gaia–KeplerSurvey and find, unsurprisingly, that both data sets are consistent with either model. We propose a hypothesis test to be performed on future surveys that can robustly ascertain which of the two mechanisms formed the radius gap, provided one dominates over the other.
Testing the Galactic Centre potential with S-stars
Authors: Zakharov Alexander F
Published: October 2021

Two groups of astronomers used the large telescopes Keck and VLT for decades to observe trajectories of bright stars near the Galactic Centre. Based on results of their observations, the astronomers concluded that trajectories of the stars are roughly elliptical and foci of the orbits are approximately coincide with the Galactic Centre position. In a last few years, a self-gravitating dark matter core–halo distribution was suggested by Ruffini, Argüelles, Rueda (RAR) and this model was actively used in consequent studies. In particular, recently it has been claimed that the RAR-model provides a better fit of trajectories of bright stars in comparison to the conventional model with a supermassive black hole. The dark matter distribution with a dense core having a constant density as it was suggested in the RAR-model leaves trajectories of stars elliptical like in Kepler’s two-body problem. However, in this case not the foci of the ellipses coincide with the Galactic Centre but their centres while the orbital periods do not depend on semi-major axes. These properties are not consistent with the observational data for trajectories of bright stars.