bluuebunny/crossref_metadata_2025 huggingface dataset:
Venting percutaneous radiologic gastrostomy in malignant bowel obstruction: safety and effectiveness in a comprehensive cancer centre
Authors: Peiró Inmaculada , Milla Jennifer , Arribas Lorena , Hurtós Laura , González-Tampán Ana Regina , Bellver Marta , Fort Eduard , Molina-Mata Kevin , Joudanin Jonathan R , Valcarcel Joana , González-Barboteo Jesús
Published: September 2022

Objective

Approximately 20% of established malignant bowel obstruction (MBO) patients do not respond to pharmacological treatment. In these cases, venting percutaneous radiologic gastrostomy (VPRG) may be useful. Existing evidence is based on retrospective studies with methodological limitations. The purpose of this study is to describe safety and effectiveness for symptom control after VPRG placement in a prospective cohort of MBO patients.

Methods

Complications of VPRG placement, symptom control, destination on discharge and survival were analysed.

Results

Twenty-one patients were included, 13 (61.9%) of whom were women. Mean age was 62.7 years (36–85). Local pain (n=8, 38.1%) and peristomal leakage (n=4, 19%) were the most frequent minor complications. No major complications occurred. Nausea and vomiting were relieved in most patients (n=20, 95.2%) after VPRG, and small quantities of liquid diet were introduced to these patients. Median time to death after VPRG was 13 days (IQR 8.6–17.4). Thirteen patients (61.9%) were discharged, with seven of them (33.3%) returning home.

Conclusions

When pharmacological treatment fails, the use of VPRG in MBO patients may be feasible, safe and effective.
Limiting distribution of extremal eigenvalues of d-dimensional random Schrödinger operator
Authors: Kawaai Kaito , Maruyama Yugo , Nakano Fumihiko
Published: September 2022

We consider the Schrödinger operator with random decaying potential on [Formula: see text] and showed that, (i) Integrated Density of States (IDS) coincide with that of free Laplacian in general cases, (ii) the set of extremal eigenvalues, after rescaling, converges to an inhomogeneous Poisson process, under certain condition on the single-site distribution, and (iii) there are “border-line” cases, such that we have Poisson statistics in the sense of (ii) above if the potential does not decay, while we do not if the potential does decay.
A Multi-Layer Acoustic Neural Network-Based Intelligent Early Diagnosis System for Rheumatic Heart Disease
Authors: Kumar K. Antony , Belinda M. J. Carmel Mary
Published: September 2022

Rheumatic Heart Disease (RHD) is a disorder of heart caused by streptococcal throat infection followed by the organ damage, irreversible valve damage and heart failure. Acute Rheumatic Fever (ARF) is a precursor to the disease. Sometimes, RHD can occur without any signs or symptoms, and if there are any symptoms, they occur with the infection in the heart valves and fever. Due to these issues, respiratory problems occur with chest pain and tremors. Additionally, the symptoms include faint, heart murmurs, stroke and unexpected collapse. The techniques available try to detect the RHD as early as possible. Although the recent medical health care department uses crucial techniques, they are not accurate in terms of symptom classification, precision and prediction. On the scope, we are developing Multi-Layered Acoustic Neural (MLAN) Networks to detect the RHD symptoms using heart beat sound and Electrocardiogram (ECG) measurements. In this proposed MLAN system, the novel techniques such as multi-attribute acoustic data sampling model, heart sound sampling procedures, ECG data sampling model, RHD Recurrent Convolutional Network (RRCN) and Acoustic Support Vector Machine (ASVM) are used for increasing the accuracy. In the implementation section, the proposed model has been compared to the Long Short-Term Memory-based Cardio (LSTC) data analysis model, Cardio-Net and Video-Based Deep Learning (VBDL) techniques. In this comparison, the proposed system has 10%–17% higher accuracy in RHD detection than existing techniques.
A note on self-centralizing subgroups and general subgroups of finite groups being a TI-subgroup or subnormal
Authors: Shi Jiangtao
Published: September 2022

Based on some known researches about some self-centralizing subgroups of finite groups being a TI-subgroup or subnormal, we indicate that the following two conditions hypotheses are equivalent: Suppose that [Formula: see text] is a finite group, then every self-centralizing subgroup (or non-nilpotent subgroup, or non-abelian subgroup) of [Formula: see text] is a TI-subgroup or subnormal if and only if every subgroup (or non-nilpotent subgroup, or non-abelian subgroup) of [Formula: see text] is a TI-subgroup or subnormal, which implies that the self-centralizing hypothesis can be removed from some known results.
Extensions and Well’s type exact sequence of skew braces
Authors: Rathee Nishant
Published: September 2022

In this paper, we describe the split exact sequences of skew left braces. We define a free action of the second cohomology group of a skew left brace [Formula: see text] by [Formula: see text] on [Formula: see text] and show that this action becomes transitive if [Formula: see text] is a trivial skew brace. We also generalize the Well’s type exact sequence for extensions by the trivial skew brace.
Some generalizations of Springer’s theorem in characteristic two
Authors: Nokhodkar A.-H.
Published: September 2022

It is shown that an anisotropic [Formula: see text]-fold system of hermitian forms over a quaternion algebra in characteristic two remains anisotropic over all odd degree extensions of the base field. It is also shown that an anisotropic orthogonal involution on a central simple algebra of co-index 3 in characteristic two is anisotropic over any odd degree extension of the ground field.
Efficient generation of ideals over a certain monoid algebra
Authors: Mallick Provanjan , Zinna Md. Ali
Published: September 2022

Let [Formula: see text] be a ring of dimension [Formula: see text] containing [Formula: see text] and [Formula: see text]. This paper examines the question of efficient generation of ideals in [Formula: see text].
Twin-free cliques in annihilator graphs of commutative rings
Authors: Tohidi N. Kh. , Hosseini A. , Nikandish R.
Published: September 2022

For a connected graph [Formula: see text] a clique [Formula: see text] is twin-free if every pair of elements of [Formula: see text] have distinct closed neighborhoods and the number of elements in a twin-free clique of maximum cardinality is called twin-free clique number of [Formula: see text]. The annihilator graph [Formula: see text] of a commutative and unital ring [Formula: see text] is a graph whose vertices are all non-zero zero-divisors of [Formula: see text] and there is an edge between two distinct vertices [Formula: see text] if and only if [Formula: see text] is properly contained in [Formula: see text]. In this paper, twin-free clique number of [Formula: see text] is computed and as an application the strong metric dimension of [Formula: see text] is characterized. Among other things, for a reduced ring [Formula: see text], the forcing strong metric dimension of [Formula: see text] is given.
Security Analysis of Zigbee Protocol Implementation via Device-agnostic Fuzzing
Authors: Ren Mengfei , Ren Xiaolei , Feng Huadong , Ming Jiang , Lei Yu
Published: September 2022

Zigbee is widely adopted as a resource-efficient wireless protocol in the IoT network. IoT devices from manufacturers have recently been affected due to major vulnerabilities in Zigbee protocol implementations. Security testing of Zigbee protocol implementations is becoming increasingly important. However, applying existing vulnerability detection techniques such as fuzzing to the Zigbee protocol is not a simple task. Dealing with low-level hardware events still remains a big challenge. For the Zigbee protocol, which communicates over a radio channel, many existing protocol fuzzing tools lack a sufficient execution environment.

To narrow the gap, we designed
Z-Fuzzer
, a device-agnostic fuzzing tool for detecting security flaws in Zigbee protocol implementations. To simulate Zigbee protocol execution,
Z-Fuzzer
leverages a commercial embedded device simulator with pre-defined peripherals and hardware interrupt setups to interact with the fuzzing engine. Z-Fuzzer generates more high-quality test cases with code-coverage heuristics. We compare Z-Fuzzer with advanced protocol fuzzing tools, BooFuzz and Peach fuzzer, on top of Z-Fuzzer’s simulation platform. Our findings suggest that Z-Fuzzer can achieve greater code coverage in Z-Stack, a widely used Zigbee protocol implementation. Compared to BooFuzz and Peach, Z-Fuzzer found more vulnerabilities with fewer test cases. Three of them have been assigned CVE IDs with high CVSS scores (7.5~8.2).
PiDRAM: A Holistic End-to-end FPGA-based Framework for Processing-in-DRAM
Authors: Olgun Ataberk , Luna Juan Gómez , Kanellopoulos Konstantinos , Salami Behzad , Hassan Hasan , Ergin Oguz , Mutlu Onur
Published: September 2022

Commodity DRAM-based processing-using-memory (PuM) techniques that are supported by off-the-shelf DRAM chips present an opportunity for alleviating the data movement bottleneck at low cost. However, system integration of these techniques imposes non-trivial challenges that are yet to
be
solve
d
. Potential solutions to the integration challenges require appropriate tools to develop any necessary hardware and software components. Unfortunately, current proprietary computing systems, specialized DRAM-testing platforms, or system simulators do not provide the flexibility and/or the holistic system view that is necessary to properly evaluate and deal with the integration challenges of commodity DRAM-based PuM techniques.

We design and develop Processing-in-DRAM (PiDRAM),
the first
flexible end-to-end framework that enables system integration studies and evaluation of real, commodity DRAM-based PuM techniques. PiDRAM provides software and hardware
components
to rapidly integrate PuM techniques across the whole system software and hardware stack. We implement PiDRAM on an FPGA-based RISC-V system.
To demonstrate the flexibility and ease of use of PiDRAM, we implement and evaluate two state-of-the-art commodity DRAM-based PuM techniques: (i) in-DRAM copy and initialization (RowClone) and (ii) in-DRAM true random number generation (D-RaNGe)
. We describe how we solve key integration challenges to make such techniques work and be effective on a real-system prototype, including memory allocation, alignment, and coherence. We observe that end-to-end RowClone speeds up bulk copy and initialization operations by 14.6× and 12.6×, respectively, over conventional CPU copy, even when coherence is supported with inefficient cache flush operations. Over PiDRAM’s extensible codebase, integrating both RowClone and D-RaNGe end-to-end on a real RISC-V system prototype takes only 388 lines of Verilog code and 643 lines of C++ code.
The National Longitudinal Study of Adolescent to Adult Health (Add Health): An Underused Resource for Developmental Science
Authors: Harris Kathleen Mullan , Halpern Carolyn Tucker
Published: September 2022

The National Longitudinal Study of Adolescent to Adult Health (Add Health) represents a data treasure for developmental psychologists working in both adolescent and life-span development. Add Health is a nationally representative sample of more than 20,000 adolescents in grades 7–12 in 1994–1995, who were followed for 25 years into early midlife over five interview waves. The innovative multilevel design collected direct measures of the social contexts of adolescent life and tracked developmental outcomes in health, health behaviors, cognition, achievement, and relationships over time. Biological data appropriate to the developmental stages of the cohort and relevant biosocial processes were integrated into the longitudinal waves of data collection. This review describes Add Health's design and data contents and highlights illustrative Add Health articles that examine developmental processes and outcomes in the areas of mental health, health behavior, cognition, and relationships. We conclude with new opportunities for developmental analyses and suggest future areas of research.
Adeno-Associated Virus Gene Therapy for Hemophilia
Authors: Samelson-Jones Benjamin J. , George Lindsey A.
Published: September 2022

In vivo gene therapy is rapidly emerging as a new therapeutic paradigm for monogenic disorders. For almost three decades, hemophilia A (HA) and hemophilia B (HB) have served as model disorders for the development of gene therapy. This effort is soon to bear fruit with completed pivotal adeno-associated viral (AAV) vector gene addition trials reporting encouraging results and regulatory approval widely anticipated in the near future for the current generation of HA and HB AAV vectors. Here we review the clinical development of AAV gene therapy for HA and HB and examine outstanding questions that have recently emerged from AAV clinical trials for hemophilia and other monogenic disorders.
Comprehensive Exploration of M2 Macrophages and Its Related Genes for Predicting Clinical Outcomes and Drug Sensitivity in Lung Squamous Cell Carcinoma
Authors: Han Yansong , Li Yuexia
Published: September 2022

Background. M2 macrophages play an important role in cancers. However, the role of M2 macrophages has not been clarified in lung squamous cell carcinoma. Methods. All the open-accessed data were downloaded from The Cancer Genome Atlas database. All the analysis was performed in the R software. The CIBERSORT algorithm was utilized to quantify the immune cell infiltration in the tumor microenvironment. LASSO regression and multivariate Cox regression analysis were carried out for the creation of the prognostic model. Pathway enrichment analysis was performed using the single sample Gene Set Enrichment Analysis (ssGSEA) and clueGO algorithm. Results. In our study, we comprehensively explored the role of M2 macrophages and its related genes in LUSC patients. We found that the patients with high M2 macrophage infiltration tend to have a worse prognosis. Also, some oncogenetic pathways were activated in the patients with high M2 macrophage infiltration. Further, a prognosis model based on six M2 macrophage-related genes was established, including TRIM58, VIPR2, CTNNA3, KIAA0408, CLEC4G, and MATN4, which showed a good prognosis prediction efficiency in both training and validation cohort. Pathway enrichment analysis showed that the pathway of allograft rejection, bile acid metabolism, coagulation, inflammatory response, IL6/JAK/STAT3 signaling, hedgehog signaling, peroxisome, and myogenesis were significantly activated in the high-risk patients. Based on the results of an investigation of immune infiltration, risk score was found to have a positive correlation with M2 macrophages and resting CD4+ memory T cells, but a negative correlation with follicular helper T cells, M1 macrophages, and Tregs. In addition, we discovered that patients in high-risk groups may respond better to immunotherapy than individuals in lower-risk groups. However, low-risk patients might be more sensitive to cisplatin. Conclusions. Our model is a powerful tool to predict LUSC patient prognosis and could indicate the sensitivity of immunotherapy and chemotherapy.
IOTEML: An Internet of Things (IoT)-Based Enhanced Machine Learning Model for Tumour Investigation
Authors: Swaminathan B. , Choubey Siddhartha , Anushkannan N. K , Arumugam Jeevanantham , Suriyakrishnaan K , Almoallim Hesham S. , Alharbi Sulaiman Ali , Soma S. R. , Mosissa Ramata
Published: September 2022

In the current age of technology, various diseases in the body are also on the rise. Tumours that cause more discomfort in the body are set to increase the discomfort of most patients. Patients experience different effects depending on the tumour size and type. Future developments in the medical field are moving towards the development of tools based on IoT devices. These advances will in the future follow special features designed based on multiple machine learning developed by artificial intelligence. In that order, an improved algorithm named Internet of Things-based enhanced machine learning is proposed in this paper. What makes it special is that it involves separate functions to diagnose each type of tumour. It analyzes and calculates things like the size, shape, and location of the tumour. Cure from cancer is determined by the stage at which we find cancer. Early detection of cancer has the potential to cure quickly. At a saturation point, the proposed Internet of Things-based enhanced machine learning model achieved 94.56% of accuracy, 94.12% of precision, 94.98% of recall, 95.12% of F1-score, and 1856 ms of execution time. The simulation is conducted to test the efficacy of the model, and the results of the simulation show that the proposed Internet of Things-based enhanced machine learning obtains a higher rate of intelligence than other methods.
Effects of Smoking on Aggression, Big Five Personality Factors, and Polymorphisms in HTR2A, DRD4, and MAOA among Egypt University Students
Authors: Aboelsaad Marina , Soliman Omar , Medhat Ahmed , Khalil Omar , AlWahsh Mawada , Wageh Yasmeen , ElSaied Amira , ElShrkawy Hadeer , Abdulhafiz Huda , Sayed Moustafa , Bittoun Renee
Published: September 2022

Introduction. To find genetic variants in the DRD4 and HTR2A genes’ promoter regions and exons that are associated with tobacco smoking and nicotine addiction in Egyptian university students as well as to study the association between personality traits and smoking status. Methods. A self-administered questionnaire about cigarette smoking and personality attributes (Big Five Inventory, ESPAD Questionnaire on Substance Abuse, and Buss-Perry Aggression Questionnaire). The participants in the study were 90 nonsmokers (NS) and 88 current smokers (CS), who were divided into two groups depending on their cigarette consumption per day (cpd): 55 heavy smokers (HS, >20 cpd) and 33 light smokers (LS, 1–10 cpd). Four and eight single nucleotide polymorphisms (SNPs) in the DRD4, HTR2A, and MOA genes, respectively, were genotyped. Results. Smokers scored lower on neuroticism, agreeableness, conscientiousness, openness, and extraversion than nonsmokers, but higher on aggression. Furthermore, the C allele of rs1800955 in DRD4 was associated with cigarette smoking in the HS vs. NS and LS vs. NS studies. The T allele of the HTR2A rs6313 gene was discovered to be strongly associated with cigarette smoking. There was no link discovered between MOA rs1137070 and MOA rs1137070. Conclusions. Using a comprehensive personality model (FFM), this study repeats and extends earlier research. Personality and genetic studies may aid in the development of a more complete and conclusive understanding of cigarette smoking, as well as more precise policies and guidelines for smoking cessation and quitting.
B-Cell Translocation Gene 2 Upregulation Is Associated with Favorable Prognosis in Lung Adenocarcinoma and Prolonged Patient Survival
Authors: Liang Junting , Cheng Linna , Gao Haiyan , Fu Wanying , Zhang Xiulei , Zhang Jianhua , Li Jinming , Chen Chuanliang
Published: September 2022

The tumor suppressor protein B-cell translocation gene 2 (BTG2) is downexpressed in lung adenocarcinoma (LUAD); however, its role in LUAD survival remains unknown. This investigation is aimed at exploring the activity of BTG2 in LUAD. We analyzed BTG2 expression in LUAD datasets of the TCGA database and examined that BTG2 was markedly downregulated in comparison with adjacent normal tissues. The prognostic analysis suggested that higher expression of BTG2 protein correlates with prolonged survival in patients. Vectors expressing BTG2 were stably transduced into lung adenocarcinoma A549 cells. The overexpression of BTG2 in A549 cells causes cellular G1 phase arrest but did not affect cell proliferation, accompanied by increased activation of NF-κB. Our data indicate that BTG2 overexpression may trigger an autoregulatory prosurvival NF-κB pathway, which is resistant to environmental intervention owing to an increased level of BTG2.
Nanotitanium Oxide Particles and Jute‐Hemp Fiber Hybrid Composites: Evaluate the Mechanical, Water Absorptions, and Morphological Behaviors
Authors: Mahesha C. R. , Suprabha R. , Harne Mahesh S. , Galme Sachin G. , Thorat Sandeep G. , Nagabhooshanam N. , Seikh A. H. , Siddique M. H. , Markos Mebratu
Published: September 2022

Organic fiber‐based biocomposites have gained prominence in a variety of sectors over the last four to five years due to their exceptional mechanical and physical properties. Natural fiber‐based composites are increasingly being employed in autos, ships, airplanes, and infrastructure projects. The current study will look at the effect of nanotitanium oxide (TiO2) fillers on the properties of hybridised jute‐hemp‐based composites. In this work, TiO2‐filled biocomposites were created using the hand layup method in hybrid jute‐hemp composites containing jute fiber mats, woven hemp mats, and epoxy resin. After nanotitanium oxide fillers were injected in various weight proportions, the mechanical properties of fiber‐reinforced polymers were investigated. The mechanical properties of laminated composites were tested using the ASTM standard. Compared to 2 and 4 wt.% of TiO2, the 6 wt.% was provided the highest mechanical strength. Among the different types of specimen, the E‐type specimen (30 wt.% of hemp, 7 wt.% of jute, 57 wt.% of epoxy, and 6 wt.% of TiO2) gives their highest contribution, i.e., for tensile 24.21%, for flexural 25.03%, and for impact 24.56%. The scanning electron microscope was utilized to analyse the microstructures of nanocomposites.
Variable Structure Control and Its Ground Experimental Test for the Space Station Robot
Authors: Zhang Feilong , Zhang Bi , Han Bing , Qu Danyang , Zhao Xingang
Published: September 2022

Building a simulated weightless test system on the ground while making comprehensive comparisons of design controllers for a large and heavy multijointed space station robot is not an easy task. To save cost and improve the efficiency of the test, this paper develops a plan in which controllers undergo preliminary testing in a 6-DOF industrial robot. The key idea is gravity compensation included within the dynamic control algorithm of the robot to replace the function of the microgravity environment. It is generally difficult to build an accurate dynamic model for a serial-joint robot in a practical manner. Therefore, to guarantee the stability of the 6-DOF industrial robot in which the dynamic model is built inaccurately, we propose one of the simplest variable structure (VS) controllers, and the stability of the system is analyzed through the Lyapunov method. Last, experiments are carried out to provide preliminary comparisons among three potential algorithms for the space robot in a low-cost and efficient approach.
Borderless Fusion Financial Management Innovation Based on Speech Recognition Technology
Authors: Yang Lin , Fan Zehao , Zhou Jiaqi
Published: September 2022

In recent years, the rapid development of information technology has affected the operation of the world economy, and the emergence of e-commerce has decreased significantly. The development of modern information technology, especially the development of Internet technology, provides a solid foundation for e-commerce. The time and space gap between economic operators is shortened, and resources are shared as widely as possible. Based on a comprehensive and in-depth study of language recognition technology. However, the current e-commerce financial management still uses the traditional accounting method, which is inefficient and cannot be integrated with new technologies. This paper proposes a design scheme for a nonspecific person and small vocabulary language recognition system based on SPCE061A processor. This integrated system can be combined with data acquisition and language input technology and constitute a data acquisition and input system. It is used for data collection and input of instruments and meters in the workplace to improve work efficiency. This paper proposes algorithms based on time-domain energy and zero-crossing rate detection, detection based on entropy function method, and detection based on the double-threshold method. The speech recognition technology is analyzed in detail, and a new model of financial management is constructed. Accounting information disclosure is a virtuous circle of “promoting capital management with appropriate decentralization.” The experimental results in this paper show that through model construction, the calculated WER is 0 dm, 7 dm, 15 dm, and 11 dm, respectively, and it is concluded that the system exhibits good antinoise performance.
Connecting to Nature through 360° Videos during COVID-19 Confinement: A Pilot Study of a Brief Psychological Intervention
Authors: Navarrete Jaime , Navarro-Siurana Jessica , Herrero Rocío , Vara Ma Dolores , Miragall Marta , Baños Rosa
Published: September 2022

Psychological interventions have been shown to be beneficial in mitigating stress related to COVID-19 confinement. According to theories of restorative environments, exposure to natural surroundings has positive effects on well-being and stress through its restorative qualities. With 360° video-based Virtual Reality (VR), people can be exposed to nature and so better manage the consequences associated with mobility restrictions during confinement. The main aim of this pilot study was to examine whether a 360° video-based VR intervention composed of five 13-minute sessions (once a day) has positive effects on affect, well-being, and stress. The sample was made up of 10 participants (4 men and 6 women; age : M = 46.5, SD = 11.7) who were confined at home (voluntarily or not) during the COVID-19 pandemic. Participants were instructed to watch a 360° video each day (of a “beach” or “lake” environment) using their smartphone and VR glasses sent to them by mail. Participants responded with several self-reports before and/or after each session (emotions and sense of presence) and before and/or after the intervention (affect, well-being, perceived stress, perceived restorativeness of nature, and the usefulness and acceptability of the intervention). Results showed a tendency to improve positive (e.g., happiness) and negative (e.g., anxiousness) emotions and experience a high sense of presence after each session. Moreover, perceived restorative qualities of the environment and their cognitive and behavioral effects were high. A significant decrease in negative affect was found after the intervention. Usefulness and acceptability were also high. This is the first study to show that an affordable and accessible technology can be used to overcome the negative consequences of confinement and counteract its harmful psychological effects.
Optimization of Residential Landscape Design and Supply Chain System Using Intelligent Fuzzy Cognitive Map and Genetic Algorithm
Authors: Deng Tingyin
Published: September 2022

This work intends to optimize residential landscape design and Supply Chain (SC) network systems. First, Fuzzy Cognitive Map (FCM) intelligent assistance and genetic algorithm (GA) are used to study residential landscape design and its integration with SC deeply. Weight matrix interactions are employed to implement iterative inference for FCM. The functions are transformed to unify variables of different scopes. Subsequently, a weighting method is proposed to deal with the disadvantage of the simple average method being too general. In addition, the Hebbian learning algorithm is used to adjust the state nodes and the connection weights. Finally, according to the fitness function of the GA and logistic regression (LR) model, residential landscape design and SC are combined. The simulation experiment results show that the causal relationship analysis between SC networks under fuzzy cognition shows that the state errors of each specific situation are 0.21, 0.16, and 0.24, respectively. The total average error is 0.21 in the case of multiple iterations. The average error of the result vector under fuzzy cognition and the operation of the actual result is 0.20, 0.15, and 0.24, respectively, and the error value is much reduced. The simulation accuracy of the GA-LR method for residential landscape design is improved from 77% to 84.7%. The “kappa coefficient” is also improved to 82.3%. The conclusion shows that the weight matrix is used to analyze the high-quality performance of landscape design according to the specific situation of SC. For each specific case, FCM is effective in reducing errors over multiple iterations. Under the GA-LR method, fewer geographic location types and larger accuracy deviations can improve the simulation accuracy.
Some Formulas for Horn’s Hypergeometric Function

G

B

of Three Variables
Authors: Shehata Ayman , Moustafa Shimaa I. , Younis Jihad , Aydi Hassen
Published: September 2022

Agarwal et al. (2021) established the extension of several fundamental contiguous relations for

G

B

. Our aim in this work is to investigate several properties of differentiation formulas, differential equations, recursion relations, differential recursion relations, confluence formulas, series representations, integration formulas, and infinite summations for Horn’s hypergeometric function

G

B

of three variables. Some well-known particular cases have additionally been given.
Construction and Application of the Talent Training System in Colleges and Universities Based on the Fuzzy Analytic Hierarchy Process
Authors: Yu Yan , Qiu Jun
Published: September 2022

At present, the competition among talents to seize jobs is becoming more and fiercer. How to stand out in the fierce competition for talents and seize market resources is a problem that every graduate must think deeply. Domestic research on the composition of the implementation elements of talent training in colleges and universities from the perspective of excellent school talent training has achieved fruitful results. Their measures and implementation ideas mainly include the following aspects: first, analyze the system of talent training in colleges and universities; second, analyze the teaching methods of college teachers; third, analyze the future development direction of talents. Taking a university as a pilot unit, this paper constructs a talent training system based on the combination method of fuzzy hierarchy, determines the training goal according to students' own ability, formulates the talent training scheme according to the goal, determines the rectangular array relationship between the training system and students' own ability requirements and attaches importance to practical teaching. The algorithm used in this paper firstly establishes a hierarchical structure model and then combines the relevant measures of AHP to sort the weights of indicators and finally calculates the entropy value by quoting entropy weight. We use the fuzzy method combined with hierarchical analysis to evaluate the five indexes of students' own influencing factors, such as learning attitude, basic knowledge, cooperation ability, development ability, and professional ability. It can be seen that the algorithm model is more accurate and the error value is the smallest. Compared with their combination method, the fuzzy evaluation method and the hierarchical analysis method are practical, and the fuzzy method combined with the hierarchical analysis combination method has more practical significance. Finally, the employment situation of graduates is compared and analyzed to further highlight the effectiveness of the model.
Simultaneous Determination of 32 Pyrrolizidine Alkaloids in Two Traditional Chinese Medicine Preparations by UPLC-MS/MS
Authors: Cheng Shi , Sun Wei , Zhao Xiaoning , Wang Ping , Zhang Wensheng , Zhang Shunnan , Chang Xiangwei , Ye Zhengliang
Published: September 2022

Pyrrolizidine alkaloids (PAs) constitute a class of phytotoxin which demonstrates strong hepatotoxicity. In China, many plants containing PAs are used as traditional medicines or medicinal preparations, which could harm human health and safety. Xiaoyao Tablet (XYT) is an antidepressant drug registered in the European Union (EU), Compound Danshen Dropping Pills (CDDP) is a commonly used drug for coronary heart disease, and phase III clinical study is ongoing in the United States. The purpose of this study is to provide data to support the use of Chinese medicine preparations internationally and to establish analytical methods for 32 PAs in XYT and CDDP. The extraction parameters that were optimized include solid-phase extraction (SPE) cartridge, extraction method, and extraction solvent. Then ultra-performance liquid chromatography coupled with triple-quadrupole linear ion-traptandem mass spectrometry (UPLC-MS/MS) was developed to effectively and efficiently quantify the 32 PAs of the XYT and CDDP. The analytical methods for XYT and CDDP were verified respectively. For XYT, the analytical method for 32 PAs was linear, and the correlation coefficient r was greater than 0.994; the recovery (REC%) at 10–2000 μg/kg was 73.3%–118.5%, and the relative standard deviation (RSD%) was 2.1%–15.4%. The CDDP REC% was 71.8%–112.0%, and the RSD% was 2.0%–17.1%. This study provides technical and data support for the registration of Chinese patented medicines in the EU, controls quality and ensures safety, and is committed to the internationalization and standardization of Chinese patented medicines.
Adsorption of Crystal Violet Dye from Aqueous Solution using Industrial Pepper Seed Spent: Equilibrium, Thermodynamic, and Kinetic Studies
Authors: Sulthana Razia , Taqui Syed Noeman , Syed Usman Taqui , Khan T. M. Yunus , Khadar Shaik Dawood Abdul , Mokashi Imran , Shahapurkar Kiran , Kalam M. A. , Murthy H. C. Ananda , Syed Akheel Ahmed
Published: September 2022

The economic viability of adsorbing crystal violet (CV) using pepper seed spent (PSS) as a biosorbent in an aqueous solution has been studied. A parametrical investigation was conducted considering parameters like initial concentration of dye, time of contact, pH value, and temperature variation. The analysis of experimental data obtained was carried out by evaluating with the isotherms of Freundlich, Sips, Tempkin, Jovanovic, Brouers–Sotolongo, Toth, Vieth–Sladek, Radke–Prausnitz, Langmuir, and Redlich–Peterson. The adsorption kinetics were studied by implementing the Dumwald-Wagner, Weber-Morris, pseudo-first-order, pseudo-second-order, film diffusion, and Avrami models. The experimental value of adsorption capacity ([Formula: see text]) was observed to be quite close to the Jovanovic isotherm adsorption capacity ([Formula: see text]) at ([Formula: see text]), coefficient of correlation of 0.945. The data validation was found to conform to that of pseudo-second-order and Avrami kinetic models. The adsorption process was specified as a spontaneous and endothermic process owing to the thermodynamic parametrical values of [Formula: see text], [Formula: see text], and [Formula: see text]. The value of [Formula: see text] is an indicator of the process’s physical nature. The adsorption of CV to the PSS was authenticated from infrared spectroscopy and scanning electron microscopy images. The interactions of the CV-PSS system have been discussed, and the observations noted suggest PSS as a feasible adsorbent to extract CV from an aqueous solution.
WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Authors: Kim Kee-Beom , Kim Dong-Wook , Kim Youngchul , Tang Jun , Kirk Nicole , Gan Yongyu , Kim Bongjun , Fang Bingliang , Park Jae-ll , Zheng Yi , Park Kwon-Sik
Published: September 2022

WNT signaling represents an attractive target for cancer therapy due to its widespread oncogenic role. However, the molecular players involved in WNT signaling and the impact of their perturbation remain unknown for numerous recalcitrant cancers. Here, we characterize WNT pathway activity in small cell lung cancer (SCLC) and determine the functional role of WNT signaling using genetically engineered mouse models. β-Catenin, a master mediator of canonical WNT signaling, was dispensable for SCLC development, and its transcriptional program was largely silenced during tumor development. Conversely, WNT5A, a ligand for β-catenin–independent noncanonical WNT pathways, promoted neoplastic transformation and SCLC cell proliferation, whereas WNT5A deficiency inhibited SCLC development. Loss of p130 in SCLC cells induced expression of WNT5A, which selectively increased Rhoa transcription and activated RHOA protein to drive SCLC. Rhoa knockout suppressed SCLC development in vivo, and chemical perturbation of RHOA selectively inhibited SCLC cell proliferation. These findings suggest a novel requirement for the WNT5A–RHOA axis in SCLC, providing critical insights for the development of novel therapeutic strategies for this recalcitrant cancer. This study also sheds light on the heterogeneity of WNT signaling in cancer and the molecular determinants of its cell-type specificity.

Significance:

The p130–WNT5A–RHOA pathway drives SCLC progression and is a potential target for the development of therapeutic interventions and biomarkers to improve patient treatment.
Natural Course of Optic Disc Pit Maculopathy: An Optical Coherence Tomography Study
Authors: Taslipinar Uzel Ayse Guzin , Gelisken Faik , Bartz-Schmidt Karl Ulrich , Neubauer Jonas
Published: September 2022

Purpose: The aim of this study was to analyze the impact of OCT characteristics on the natural course of optic disc pit maculopathy (ODP-M). Methods: This was a single-center, retrospective, observational case series. Patients with ODP-M were included in the study. Baseline demographic characteristics, central macular thickness (CMT), IPP, subretinal fluid (SRF), subretinal precipitations, outer retinal fluid (ORF), and outer retinal layer hole were evaluated. The changes in the OCT characteristics were analyzed with respect to the best-corrected visual acuity (BCVA) from baseline to the last visit. Results: Twenty-two eyes of 22 patients were evaluated with a mean follow-up time of 37.6 (median 22) months. The mean BCVA was 0.31 logMAR at baseline and 0.28 logMAR at the final visit (p = 0.521). Baseline BCVA was significantly related to CMT (β coefficient 0.001, p = 0.002). Mean BCVA increased in 7 patients (group 1), remained stable in nine (group 2), and decreased (group 3) in 6 patients. No significant difference was found between the groups regarding the baseline BCVA, CMT, and extent of retinal fluid. In patients with subretinal deposits, BCVA remained stable in 3 patients and worsened in one. ORF was recorded in all patients. In patients with SRF, the mean change of BCVA during follow-up differed significantly, depending on the presence (0.07 logMAR) or absence (−0.125 logMAR) of SRF (p = 0.019). Conclusion: Among the OCT characteristics, SRF was a negative prognostic factor in ODP-M. Most ODP-M patients showed improved or stable vision over 3 years of follow-up. Therefore, observation may be considered in patients with reasonable vision and without SRF even when they present with remarkable OCT findings.
High Rates of Anti-αIIbβ3 Antibodies Produced by a Glanzmann Thrombasthenia Patient after First and Unique Red Blood Cells Administration
Authors: Huguenin Yoann , Levoir Laure , Bouton Muriel , Fiore Mathieu
Published: September 2022

Immunization against the platelet αIIbβ3 glycoprotein due to blood transfusion represents one of the most severe complications in Glanzmann thrombasthenia (GT) disease. Anti-αIIbβ3 isoantibodies development may lead to ineffective platelet transfusion and can, in case of pregnancy, cross the placenta leading to fetal thrombocytopenia. We describe here the case of a girl with type I GT who developed high rates of anti-αIIbβ3 isoantibodies after first and unique blood transfusion. Surprisingly, this patient had only received red blood cell concentrates and immunization was presumably stimulated by the residual presence of platelets in concentrates. This study emphasizes the need for regular anti-αIIbβ3 antibodies screening in GT, even though patients have never been previously transfused with platelet concentrates.
Disinfection Effect of Hexadecyl Pyridinium Chloride on SARS-CoV-2 in vitro
Authors: Chen Ke-da , Ma Fei-ke , Wang Qing-jing , Wang Ying , Zhuang Xin-yi , Zhang Xu-ning , Mao Hai-yan , Zhang Yan-jun
Published: September 2022

The novel coronavirus (COVID-19 or 2019-nCoV) is a respiratory virus that can exist in the mouth and saliva of patients and spreads through aerosol dispersion. Therefore, stomatological hospitals and departments have become high-infection-risk environments. Accordingly, oral disinfectants that can effectively inactivate the virus have become a highly active area of research. Hexadecyl pyridinium chloride, povidone-iodine, and other common oral disinfectants are the natural primary choices for stomatological hospitals. Therefore, this study investigated the inhibitory effect of hexadecyl pyridinium chloride on severe acute respiratory syndrome coronavirus (SARS-CoV-2) in vitro. Vero cells infected with SARS-CoV-2 were used to determine the disinfection effect; the CCK-8 method was used to determine cytotoxicity, and viral load was determined by real-time PCR. The results showed that hexadecyl pyridinium chloride has no obvious cytotoxic effect on Vero cells in the concentration range of 0.0125–0.05 mg/mL. The in vitro experiments showed that hexadecyl pyridinium chloride significantly inhibits the virus at concentrations of 0.1 mg/mL or above at 2 min of action. Thus, the results provide experimental support for the use of hexadecyl pyridinium chloride in stomatological hospitals.
Reliability of the Critical Thinking in Communication Science and Disorders: A Content-Specific Critical Thinking Assessment
Authors: Morris Richard J. , Gorham-Rowan Mary M. , Carter Matthew D. , Battaglia Dana , Olmsted Lauren M.
Published: September 2022

Introduction: Students and professionals in communication sciences and disorders (CSD) need to exhibit good critical thinking (CT) skills when engaged in clinical tasks. CSD clinicians must make decisions that are free from biases and support their claim with facts. Thus, CSD clinicians need to be trained to question their clinical practices and to skeptically evaluate new practices that develop. A content-specific CT test can help determine if students are developing these skills. However, to date, no such content-specific CT assessment exists for CSD. The purpose of this study was to determine the reliability of the current version of a specific content CT assessment, the Critical Thinking in Communication Sciences and Disorders (CTCSD). Methods: A sample of 150 CSD graduate students enrolled in three programs participated. They completed an online Qualtrics survey that consisted of the CTCSD. They completed the Qualtrics survey twice, once at the beginning of a semester and once at the end. The participant responses were independently scored by two research associates. The data were analyzed for reliability in three ways. Intra-subject reliability was assessed by comparing scores across the two testing sessions. Internal consistency of the items to measure a common construct was assessed using Cronbach’s alpha and Guttman’s Lambda 6. Inter-rater reliability was assessed using Cohen’s Kappa coefficient. In addition, the time used to complete the survey was analyzed. Results: The students from the three programs scored similarly on the CTCSD. High reliability ratings occurred for the intra-subject, internal consistency, and inter-rater measures. Discussion/Conclusion: The results indicate the reliability of the CTCSD. In combination with previous results indicating the face, construct, and criterion validity of the CTCSD, it appears to have psychometric strength. The CTCSD may help academic and clinical faculty select learning activities and focus feedback to their graduate students in order to reinforce skills the students exhibit and to develop other skills.
Urgências Oftalmológicas: o que todo médico precisa saber
Authors: Cardoso Filho Antero Pinto , Costa Luísa Canesin Dourado Figueiredo , Rocha Eduardo Melani
Published: September 2022

Queixas oftalmológicas agudas correspondem a uma importante parcela dos atendimentos clínicos de urgência. Essa revisão tem o objetivo de servir como roteiro para avaliação médica básica no paciente oftalmológico, com sugestão de ferramentas que auxiliam na avaliação clínica ocular, passando pelas queixas de olho vermelho, perda de visão e traumas, com seus respectivos diagnósticos e base dos tratamentos.
Semiologia oftalmológica
Authors: Oliveira Ítalo Pena de , Marcusso Barbara Maria Guedes , Antunes-Foschini Rosália Maria Simões , Furtado João Marcello Fórtes
Published: September 2022

No atendimento ao paciente com queixas ou manifestações oftalmológicas, é importante adotar um roteiro de avaliação que contemple uma análise completa do sistema visual. Neste texto, nosso objetivo é apresentar um roteiro de semiologia oftalmológica dividido entre anamnese e exame físico. O exame físico é estruturado a partir da avaliação da acuidade visual e das diversas estruturas do globo ocular e seus anexos.
Alterações oculares na infância e adolescência
Authors: Oliveira Ítalo Pena de , Ferreira Manuela Molina , Antunes-Foschini Rosália Maria Simões
Published: September 2022

O desenvolvimento da função visual ocorre durante a infância. Nesse período, diversas condições oculares podem estar presentes, se manifestando com comprometimento da função visual e consequente impacto no desenvolvimento geral da criança. Estrabismo, ambliopia, catarata congênita, glaucoma, retinopatia da prematuridade, ceratocone e alergias oculares são quadros que podem se manifestar na faixa etária pediátrica. Essas diversas condições fazem parte da rotina de atendimento tanto do médico generalista quanto dos diversos especialistas. Todos devem estar atendo aos sinais e sintomas, propiciando uma suspeita diagnóstica precoce e uma abordagem oportuna, a fim de se evitar comprometimento visual definitivo.
Manifestações oculares de doenças sistêmicas II: retinopatia diabética e retinopatia hipertensiva
Authors: Bastos Thaís Marino de Azeredo , Oliveira Ítalo Pena de , Jorge Rodrigo
Published: September 2022

Diante do aumento da expectativa de vida e das mudanças de hábitos e estilo de vida modernos, patologias vasculares da retina, como retinopatia hipertensiva e diabética, destacam-se como importantes causas de comprometimento visual.

A hipertensão arterial pode causar diretamente lesões na retina, coroide e nervo óptico, além de predispor à ocorrência de outras patologias vasculares, tais como oclusões venosas da retina, e ao agravamento de patologias como a retinopatia diabética.  O diabetes mellitus pode levar a múltiplas complicações oftalmológicas, sendo a retinopatia a mais prevalente e figurando como a principal causa de cegueira na população economicamente ativa.

Nesse cenário, tanto o médico generalista quanto especialistas diversos devem estar atentos ao risco de comprometimento oftalmológico e realizar manejo adequado da patologia de base, reconhecimento precoce de alterações oculares e encaminhamento oportuno para serviços especializados, de modo a evitar um comprometimento visual, econômico e social frequentemente associado a estas patologias.