bluuebunny/crossref_metadata_2025 huggingface dataset:
More HIV-1 RNA detected and quantified with the Cobas 6800 system in patients on antiretroviral therapy
Authors: Wirden Marc , Palich Romain , Abdi Basma , Valantin Marc Antoine , Tubiana Roland , Schneider Luminita , Seang Sophie , Faycal Antoine , Sellem Baptiste , Katlama Christine , Calvez Vincent , Marcelin Anne Geneviève
Published: May 2022

Background

Target-detected (TD) results or low-level viraemia (LLV) can be observed in HIV-1 patients on ART, which regularly raises questions.

Objectives

We describe here the impact on HIV-1 RNA quantification of switching from the COBAS AmpliPrep/COBAS TaqMan (CAP/CTM) to the Cobas 6800 system (C6800), based on analyses of viraemia close to the lower limit of quantification (LLoQ).

Patients and methods

We retrospectively selected two groups of patients: 200 individuals whose viral loads (VLs) were consistently <50 copies/mL with CAP/CTM for at least 3 years before switching to C6800 (group 1), and 35 other patients with confirmed LLV when C6800 was in use (group 2). In both groups, we compared several consecutive VL results performed before and after the change of quantification assay. Analyses were performed with McNemar’s paired tests or Fisher’s exact tests.

Results

In group 1, the frequency of TD results (below or above the LLoQ) increased significantly after the switch to C6800 for patients with <25% of results being TD for VLs performed with CAP/CTM (P < 0.0001). Significantly more patients had at least one VL ≥20 or ≥50 copies/mL with C6800, in both group 1 (37.0% versus 18.5%; P < 0.0001 and 6.5% versus 0%; P = 0.0009, respectively) and group 2 (100% versus 66%; P = 0.0015 and 97% versus 40%; P < 0.0001, respectively).

Conclusions

C6800 revealed residual or low-level HIV-1 RNA that was not detected with CAP/CTM, resulting in twice as many patients being found to have a VL ≥20 copies/mL. Physicians and patients should be aware of possible differences in results between assays, and it is crucial to specify the quantitative assay used in studies.
Do nurses document all discussions of patient problems and nursing interventions in the electronic health record? A pilot study in home healthcare
Authors: Song Jiyoun , Zolnoori Maryam , Scharp Danielle , Vergez Sasha , McDonald Margaret V , Sridharan Sridevi , Kostic Zoran , Topaz Maxim
Published: May 2022

Objective

To assess the overlap of information between electronic health record (EHR) and patient–nurse verbal communication in home healthcare (HHC).

Methods

Patient–nurse verbal communications during home visits were recorded between February 16, 2021 and September 2, 2021 with patients being served in an organization located in the Northeast United States. Twenty-two audio recordings for 15 patients were transcribed. To compare overlap of information, manual annotations of problems and interventions were made on transcriptions as well as information from EHR including structured data and clinical notes corresponding to HHC visits.

Results

About 30% (1534/5118) of utterances (ie, spoken language preceding/following silence or a change of speaker) were identified as including problems or interventions. A total of 216 problems and 492 interventions were identified through verbal communication among all the patients in the study. Approximately 50.5% of the problems and 20.8% of the interventions discussed during the verbal communication were not documented in the EHR. Preliminary results showed that statistical differences between racial groups were observed in a comparison of problems and interventions.

Discussion

This study was the first to investigate the extent that problems and interventions were mentioned in patient–nurse verbal communication during HHC visits and whether this information was documented in EHR. Our analysis identified gaps in information overlap and possible racial disparities.

Conclusion

Our results highlight the value of analyzing communications between HHC patients and nurses. Future studies should explore ways to capture information in verbal communication using automated speech recognition.
Rapid Extraction and Qualitative Screening of 30 Drugs in Oral Fluid at Concentrations Recommended for the Investigation of DUID Cases
Authors: Coulter Cynthia , Garnier Margaux , Moore Christine
Published: May 2022

A rapid, simple extraction method followed by qualitative screening using liquid chromatography–tandem mass spectrometry (LC–MS-MS) for drugs in oral fluid is presented. The decision points were selected to be at, or lower, than those recommended as Tier I compounds by the National Safety Council’s Alcohol, Drugs and Impairment Division for toxicological investigation of driving under the influence of drug (DUID) cases and were also at, or lower, than those recommended by Substance Abuse and Mental Health Service Administration and the Department of Transportation for Federal workplace drug testing programs. The method included 30 drugs: delta-9-tetrahydrocannabinol, amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine, cocaine, benzoylecgonine, carisoprodol, meprobamate, zolpidem, alprazolam, clonazepam, 7-aminoclonazepam, diazepam, nordiazepam, lorazepam, oxazepam, temazepam, codeine, morphine, 6-acetylmorphine, buprenorphine, fentanyl, hydrocodone, hydromorphone, oxycodone, oxymorphone, methadone, tramadol and phencyclidine. Phencyclidine was included because it is in the Federal workplace program even though it is considered a Tier II drug for DUID cases. A liquid−liquid extraction method using isopropanol, hexane and ethyl acetate to extract drugs from the oral fluid−buffer mix collected in a Quantisal™ device, followed by LC–MS-MS screening, was developed and validated according to ANSI/ASB 2019 Standard Practices for Method Validation in Forensic Toxicology. Interference studies, limit of detection, precision at the decision point, ionization suppression/enhancement and processed sample stability were determined for each drug. The method was successfully applied to proficiency specimens and routine samples received in the laboratory.
Melatonin Supplementation in Undetermined Pediatric Deaths
Authors: Bishop-Freeman Sandra C , Young Kerry A , Labay Laura M , Beuhler Michael C , Hudson Jason S
Published: May 2022

Since 2015, the North Carolina Office of the Chief Medical Examiner has investigated seven deaths of infants and toddlers, aged 2 months to 3 years, with exogenous melatonin detected upon toxicological analysis. Melatonin concentrations ranged from 3 to 1,400 ng/mL in postmortem whole blood. While the cause and the manner of all seven deaths were classified as undetermined, the analytical findings are noteworthy. Melatonin is generally considered a safe, natural product appearing in many over-the-counter supplements geared toward young children to facilitate calmness and improve sleep. Melatonin is a neurohormone, which regulates not only circadian rhythms and natural sleep but also other physiological functions. Endogenous melatonin production, derived from essential amino acid metabolism, does not begin until pineal gland maturation at ∼3 months of age with concentrations in plasma peaking during periods of darkness at ∼0.2 ng/mL. Administering commercially available melatonin supplements to infants results in levels substantially greater than endogenous sources, which should not be assumed to be safe just because of their endogenous nature. The finding of exogenous concentrations in some postmortem pediatric cases warrants attention. Several topics of interest surrounding these postmortem melatonin findings will be considered, such as minimal regulatory control over commercial products as well as the potential impact on hazardous sleeping conditions. This manuscript will outline the physiological effects of melatonin and detail the case studies from the North Carolina medical examiner system. Forensic toxicology laboratories should consider including melatonin at exogenous concentrations in their testing schemes for appropriate postmortem infant and toddler cases.
Injuries Associated With Electrical Flash Burns in Children Caused by E-bike Batteries
Authors: Zhao Xiaozhuo , Shen Yuming
Published: May 2022

The use of electric bicycles (e-bikes) has increased in China. Alongside this increased use of e-bikes, reports of injuries related to e-bikes have also increased. However, few studies have explored electrical burns from short circuits in e-bike batteries, especially among children. Our study aimed to describe the epidemiology and prognosis of e-bike-related electrical flash burns in children. This retrospective analysis examined the injury patterns and prognosis of flash burn injuries from e-bike batteries among children presenting to the emergency department of a hospital in northern China from 2009 to 2020. Data collected included demographics, mechanism of injury, time of injury, injury site, burn depth, healing time, and patient prognosis. During the study period, 82 children presented to our emergency department with these injuries (boys: n = 64, 78%; girls: n = 18, 22%). The children’s mean age was 3.5 (2.5) years. Burns occurred in all months of the year but peaked from May to August (spring and summer). Most burns were to the fingers. All burns were minor injuries that healed within 2 weeks with wound care. With the growing popularity of e-bikes, electric flash burns among children caused by e-bike batteries are increasingly common. Doctors should be aware of this special injury type to offer the correct diagnosis and treatment and provide parents with appropriate information.
Innovation in premodern islam: between non-religion, irreligion and the secular
Authors: Mustafa Abdul Rahman
Published: May 2022

Premodern Muslim juristic discussions on religious innovation (bidʿa) frequently invoke a distinction between religion and its other: the irreligious and/or non-religious secular. This demarcation disrupts accounts of the unavailability of the secular beyond the precincts of the modern West, even as the imperfect translation of premodern Islamic non-religion as secular discloses the ethnocentric provincialism of the master categories of European thought that continue to facilitate European colonialism. An alternative, premodern, Islamic account of the secular is found in the thought of Ibn Taymiyya (d. 728/1328), al-Shāṭibī (d. 790/1388) and their intergenerational interlocutors who summon an opaque and shifting, yet real, boundary between religion and the irreligious and/or non-religious secular, which they posit as distinct, oppositional, yet also co-constitutive terms. The distinctions between religion and the secular, for these scholars, arise out of their (i) purposive account of divine law, (ii) compartmentalization of religious ‘worship’ from secular ‘custom’, and (iii) creation of distinct orders of religious and secular spatio-temporality.
Traveler Mites: Population Genetic Structure of the Wing Mites Periglischrus paracaligus (Acari: Mesostigmata: Spinturnicidae)
Authors: Zamora-Mejías Daniel , Trejo-Salazar Roberto-Emiliano , Eguiarte Luis E , Ojeda Margarita , Rodríguez-Herrera Bernal , Morales-Malacara Juan B , Medellín Rodrigo A
Published: May 2022

Wing mites of the genus Periglischrus are ectoparasites exclusively associated with phyllostomid bats. These mites show high host specificity and have been studied to understand the evolutionary history of their bat hosts mainly by using a morphological variation. Through a phylogeographic approach, we analyzed the genetic diversity and population genetic structure of the ectoparasite Periglischrus paracaligus Herrin and Tipton which parasitizes Leptonycteris yerbabuenae Martínez and Villa (lesser long-nosed bat) in Mexico. By the implementation of a multilocus approach, we found that P. paracaligus populations were diverse for haplotype diversity, and had values ranging from 0.5 to 1. No genetic structuring in the P. paracaligus parasites was observed along with the distribution of the host, L. yerbabuenae, in Mexico, nor when populations or regions were compared, but our results revealed a process of historical demographic expansion in all the analyzed markers. We discuss possible scenarios that could explain the lack of population structure in the light of the data analyzed for the parasites and the biology of L. yerbabuenae, such as the interplay between parasite and host traits being responsible for the genetic make-up of parasite populations. We also inferred its phylogenetic position among wing mites parasitizing the two other species of Leptonycteris bats. Long-nosed bats’ monophyly helps to explain the observed presence of distinctive clades in the wing mite’s phylogeny in specific association with each long-nosed bat host species.
Efficacy of Trapping Methods in the Collection of Eretmapodites (Diptera: Culicidae) Mosquitoes in an Afrotropical Rainforest Region, South western Cameroon
Authors: David Forfuet Foncha , Mayi Marie Paul Audrey , Fru-Cho Jerome , Kowo Cyril , Nota Anong Damian , Esack Fonda Andongma , Djomo Charlene , Tchuinkam Timoleon , Brisco Katherine K , Sehgal Ravinder , John Cornel Anthony
Published: May 2022

Very little data exist on the biology of an afrotropical rainforest mosquito Eretmapodites (Er.) in a world undergoing dramatic changes due to deforestation. The aim was to assess the efficacy of different trapping methods in the collection of Er. mosquito in forested area.

This was a longitudinal study involving collection of mosquitoes for over two years. Multiple collection methods (grouped into two categories), were used; i) net baited and un-baited traps to collect adults, ii) techniques that target immature stages subsequently reared to adults. All males were identified by genitalia dissection. Five thousand seven hundred and four mosquitoes representing 11 genera among which 2,334 Er. were identified. Mosquito abundance was highest in the net traps (n = 1276 (56.4%)) and sweep nets (n = 393(17.4%)) respectively. The abundance was highest in green colored net traps (435(34.09%)) with significant value of χ2= 40.000, P < 0.001 and in pigeons baited traps (473 (37.06%)) with significant value of χ2= 42.000, P = 0.003. The diversity ranges from H’ = 2.65; DS = 0.84; SR = 24; ACE = 24.77 in sweep net to H’ = 0; DS = 0; SR = 1; ACE = 1 in rock pool among males mosquitoes. While for females, H = 1.14; DS = 0.71; SR = 5; ACE = 5.16, in sweep net to H = 0; DS = 0; SR = 1; ACE = 1 in rock pool, tarpaulin, resting cage.

Net traps, bamboo pot, and sweep netting are efficient in collecting high abundance of forest mosquitoes in the Talanagaye rainforest.
The Distribution, Seasonal Abundance, and Environmental Factors Contributing to the Presence of the Asian Longhorned Tick (Haemaphysalis longicornis, Acari: Ixodidae) in Central Appalachian Virginia
Authors: Cumbie A N , Whitlow A M , Arneson A , Du Z , Eastwood G
Published: May 2022

Over the past decade, Haemaphysalis longicornis, the Asian longhorned tick, has undergone a geographic range expansion in the United States, from its historical range in east Asia. This tick has been characterized by its frequent parasitism of livestock, an ability to reproduce through parthenogenesis, and its ability to transmit a variety of vector-borne pathogens to livestock, wildlife, and human hosts in its native geographic range. Thus far in the United States, 17 states have reported H. longicornis populations, including 38 counties in Virginia. These numbers come from presence-absence reports provided to the U.S. Department of Agriculture, but little has been reported about this ticks’ seasonality in Virginia or its habitat preferences. Our current study detected H. longicornis populations in seven of the nine surveyed counties in Virginia. Haemaphysalis longicornis were observed in multiple habitat types including mixed hardwood forests and pastures, with abundant H. longicornis populations detected at one particular pasture site in Wythe County. This study also attempted to investigate environmental conditions that may be of importance in predicting tick presence likelihood. While sample size limited the scope of these efforts, habitat type and climatic metrics were found to be important indicators of H. longicornis collection success and abundance for both the nymphal and larval life stages. This current study reports useful surveillance data for monitoring these tick populations as they become established in the western half of Virginia and provides insight into their current distribution and maintenance over a large study region.
Numerical solutions of a gradient-elastic Kirchhoff plate model on convex and concave geometries using isogeometric analysis
Authors: Leng Yu , Hu Tianyi , Bhopalam Sthavishtha R , Gomez Hector
Published: May 2022

In this work, we study numerical solutions of a gradient-elastic Kirchhoff plate model on convex and concave geometries. For a convex plate, we first show the well-posedness of the model. Then, we split the sixth-order partial differential equation (PDE) into a system of three second-order PDEs. The solution of the resulting system coincides with that of the original PDE. This is verified with convergence studies performed by solving the sixth-order PDE directly (direct method) using isogeometric analysis (IGA) and the system of second-order PDEs (split method) using both IGA and C0 finite elements. Next, we study a concave pie-shaped plate, which has one re-entrant point. The well-posedness of the model on the concave domain is proved. Numerical solutions obtained using the split method differ significantly from that of the direct method. The split method may even lead to nonphysical solutions. We conclude that for gradient-elastic Kirchhoff plates with concave corners, it is necessary to use the direct method with IGA.
The Effect of a Pain Educational Video Upon Child Pain-Related Memory and the Moderating Role of Parental Pain- and Non-Pain-Attending Verbalizations: An Experimental Lab-Based Study
Authors: Rheel Emma , Ickmans Kelly , Wauters Aline , Van Ryckeghem Dimitri M L , Barbé Kurt , Malfliet Anneleen , Vervoort Tine
Published: May 2022

Objectives

Early memories of pain contribute to fear and may underlie the maintenance and development of chronic pain into adulthood. Accordingly, understanding determinants that may impact children’s pain memory development is key. This study examined (a) the effect of a brief engaging pain educational video in healthy children before undergoing an experimental pain task upon children’s recalled pain intensity and pain-related fear and (b) the moderating role of parental pain- and non-pain-attending verbalizations before and after the pain task.

Methods

Seventy-seven children (8–15 years old) participated in an experimental heat pain task, including actual heat pain stimuli delivered through a thermode on their forearm. Children were randomized to the experimental group (i.e., watching a pain educational video) or the control group (i.e., no video). Children’s recalled pain intensity and pain-related fear were elicited 2 weeks later.

Results

Findings showed that recalled pain intensity (but not recalled pain-related fear) of children who watched the pain educational video was significantly lower compared to the control group (p = .028). Further, parental pain-attending verbalizations before the pain task moderated the impact of the video upon children’s recalled pain intensity (p = .038). Specifically, children in the control group, but not the experimental group, whose parents used less pain-attending verbalizations recalled higher pain intensity, whereas children whose parents used more pain-attending verbalizations recalled lower pain intensity.

Conclusions

As children’s pain memories have important implications for pain assessment, treatment, and health across the lifespan, these findings might have important implications for the prevention of development or maintenance of maladaptive pain-related outcomes.
Vena cava balloon occlusion for pulmonary embolism prevention during resection of giant uterus fibroids
Authors: Kotsis Thomas , Christoforou Panagitsa , Chatziioannou Achilles , Memos Nikolaos , Theodoraki Kassiani , Konstadoulakis Manousos
Published: May 2022

We report the case of a single 46-year-old woman presenting with huge uterine fibroids growing for the last 12 years, resulting in a recent common iliac vein thrombosis. Due to the high risk for pulmonary embolism, an occluding balloon was inserted through the right jugular vein before the abdominal incision and occluded the vena cava just inferior to the renal veins. The tumor was easily mobilized, and the vena cava bifurcation was exposed and controlled until the uterus with the masses was resected. We recommend this method for oncovascular surgeries involving deep vein thrombosis and vein thromboembolism.
Discovery of primary hyperparathyroidism following an endoscopic resection of the prostate: case report
Authors: Thomas Jordan , Khelif Adrian , Arulanantham Shrine , Lemaitre Jean , Lalive d’Epinay Jean-Emmanuel
Published: May 2022

Urological complaints related to primary hyperparathyroidism are frequently caused by the formation of urolithiasis. We report another rare clinical manifestation of primary hyperparathyroidism associated with urological symptoms. A 68-year-old man presented with dysuria related to benign prostatic hyperplasia. After undergoing endoscopic resection of the prostate, the patient’s urinary complaints persisted for several months thereafter. Urinary ultrasound revealed numerous calcifications on the prostatic resection area, requiring a cystoscopy for excision and analysis of the calcifications. This was followed by an endocrine evaluation that revealed a primary hyperparathyroidism due to a single parathyroid adenoma, which was responsible for the prostatic calcifications and the patient’s atypical symptomatology. The clinical evolution was favorable after parathyroidectomy. Symptomatic prostatic calcifications, due to primary hyperparathyroidism, on an area of the endoscopic prostate resection are uncommon. The only treatment is endocrine surgery.
Melatonin as a regulator of plant ionic homeostasis: implications for abiotic stress tolerance
Authors: Huang Xin , Tanveer Mohsin , Min Yu , Shabala Sergey
Published: May 2022

Melatonin is a highly conserved and ubiquitous molecule that operates upstream of a broad array of receptors in animal systems. Since melatonin was discovered in plants in 1995, hundreds of papers have been published revealing its role in plant growth, development, and adaptive responses to the environment. This paper summarizes the current state of knowledge of melatonin’s involvement in regulating plant ion homeostasis and abiotic stress tolerance. The major topics covered here are: (i) melatonin’s control of H+-ATPase activity and its implication for plant adaptive responses to various abiotic stresses; (ii) regulation of the reactive oxygen species (ROS)–Ca2+ hub by melatonin and its role in stress signaling; and (iii) melatonin’s regulation of ionic homeostasis via hormonal cross-talk. We also show that the properties of the melatonin molecule allow its direct scavenging of ROS, thus preventing negative effects of ROS-induced activation of ion channels. The above ‘desensitization’ may play a critical role in preventing stress-induced K+ loss from the cytosol as well as maintaining basic levels of cytosolic Ca2+ required for optimal cell operation. Future studies should focus on revealing the molecular identity of transporters that could be directly regulated by melatonin and providing a bioinformatic analysis of evolutionary aspects of melatonin sensing and signaling.
COWS: a filament finder for Hessian cosmic web identifiers
Authors: Pfeifer Simon , Libeskind Noam I , Hoffman Yehuda , Hellwing Wojciech A , Bilicki Maciej , Naidoo Krishna
Published: May 2022

The large-scale galaxy and matter distribution is often described by means of the cosmic web made up of voids, sheets, filaments, and knots. Many different recipes exist for identifying this cosmic web. Here, we focus on a sub-class of cosmic web identifiers, based on the analysis of the Hessian matrix, and proposed a method, called COsmic Web Skeleton (COWS), of separating a set of filaments cells into an ensemble of individual discreet filaments. Specifically, a thinning algorithm is applied to velocity shear tensor-based cosmic web (V-web) to identify the spine of the filaments. This results in a set of filaments with well-defined end point and length. It is confirmed that these sit at local density ridges and align with the appropriate direction defined by the underlying velocity field. The radial density profile of these curved cylindrical filaments, as well as the distribution of their lengths is also examined. The robustness of all results is checked against resolution and the V-web threshold. The code for the COWS method has been made publicly available.
Low levels of sulphur dioxide contamination of Venusian phosphine spectra
Authors: Greaves Jane S , Rimmer Paul B , Richards Anita M S , Petkowski Janusz J , Bains William , Ranjan Sukrit , Seager Sara , Clements David L , Silva Clara Sousa , Fraser Helen J
Published: May 2022

New analysis is presented of the 1.1 mm wavelength absorption lines in Venus’ atmosphere that suggested the presence of phosphine. We retrieve a sulphur dioxide observation from the JCMT archive that was simultaneous within a few days of the PH3 1-0 spectrum obtained in 2017 June, and demonstrate via a radiative transfer calculation that contamination of PH3 by SO2 was ≈10 per cent. We also present ALMA 2019 spectra of PH3 1-0 and an SO2 transition acquired simultaneously, and infer that SO2 line-contamination was ≲2 per cent (for the least-noisy half of the planetary disc). The contamination-subtracted ALMA and JCMT spectra (of 6–8σ sigma confidence) are now consistent with similar absorption-depths at the two epochs. The two values span −1.9(±0.2) 10−4 of the continuum signal (which was re-estimated for ALMA), albeit for differing planetary areas. This suggests that the abundance attributed to phosphine in Venus’ atmosphere was broadly similar in 2017 and 2019.
grumpy: a simple framework for realistic forward modelling of dwarf galaxies
Authors: Kravtsov Andrey , Manwadkar Viraj
Published: May 2022

We present a simple regulator-type framework designed specifically for modelling formation of dwarf galaxies. Despite its simplicity, when coupled with realistic mass accretion histories of haloes from simulations and reasonable choices for model parameter values, the framework can reproduce a remarkably broad range of observed properties of dwarf galaxies over seven orders of magnitude in stellar mass. In particular, we show that the model can simultaneously match observational constraints on the stellar mass–halo mass relation, as well as observed relations between stellar mass and gas phase and stellar metallicities, gas mass, size, and star formation rate, as well as general form and diversity of star formation histories of observed dwarf galaxies. The model can thus be used to predict photometric properties of dwarf galaxies hosted by dark matter haloes in N-body simulations, such as colours, surface brightnesses, and mass-to-light ratios and to forward model observations of dwarf galaxies. We present examples of such modelling and show that colours and surface brightness distributions of model galaxies are in good agreement with observed distributions for dwarfs in recent observational surveys. We also show that in contrast with the common assumption, the absolute magnitude–halo mass relation is generally predicted to have a non-power law form in the dwarf regime, and that the fraction of haloes that host detectable ultra-faint galaxies is sensitive to reionization redshift (zrei) and is predicted to be consistent with observations for zrei ≲ 9.
The first nova eruption in a novalike variable: YZ Ret as seen in X-rays and γ-rays
Authors: Sokolovsky Kirill V , Li Kwan-Lok , Lopes de Oliveira Raimundo , Ness Jan-Uwe , Mukai Koji , Chomiuk Laura , Aydi Elias , Steinberg Elad , Vurm Indrek , Metzger Brian D , Babul Aliya-Nur , Kawash Adam , Linford Justin D , Nelson Thomas , Page Kim L , Rupen Michael P , Sokoloski Jennifer L , Strader Jay , Kilkenny David
Published: May 2022

Peaking at 3.7 mag on 2020 July 11, YZ Ret was the second-brightest nova of the decade. The nova’s moderate proximity (2.7 kpc, from Gaia) provided an opportunity to explore its multiwavelength properties in great detail. Here, we report on YZ Ret as part of a long-term project to identify the physical mechanisms responsible for high-energy emission in classical novae. We use simultaneous Fermi/LAT and NuSTAR observations complemented by XMM–Newton X-ray grating spectroscopy to probe the physical parameters of the shocked ejecta and the nova-hosting white dwarf. The XMM–Newton observations revealed a supersoft X-ray emission which is dominated by emission lines of C v, C vi, N vi, N vii, and O viii rather than a blackbody-like continuum, suggesting CO-composition of the white dwarf in a high-inclination binary system. Fermi/LAT-detected YZ Ret for 15 d with the γ-ray spectrum best described by a power law with an exponential cut-off at 1.9 ± 0.6 GeV. In stark contrast with theoretical predictions and in keeping with previous NuSTAR observations of Fermi-detected classical novae (V5855 Sgr and V906 Car), the 3.5–78-keV X-ray emission is found to be two orders of magnitude fainter than the GeV emission. The X-ray emission observed by NuSTAR is consistent with a single-temperature thermal plasma model. We do not detect a non-thermal tail of the GeV emission expected to extend down to the NuSTAR band. NuSTAR observations continue to challenge theories of high-energy emission from shocks in novae.
Stellar kinematics of dwarf galaxies from multi-epoch spectroscopy: application to Triangulum II
Authors: Buttry Rachel , Pace Andrew B , Koposov Sergey E , Walker Matthew G , Caldwell Nelson , Kirby Evan N , Martin Nicolas F , Mateo Mario , Olszewski Edward W , Starkenburg Else , Badenes Carles , Daher Christine Mazzola
Published: May 2022

We present new MMT/Hectochelle spectroscopic measurements for 257 stars observed along the line of sight to the ultrafaint dwarf galaxy Triangulum II (Tri II). Combining results from previous Keck/DEIMOS spectroscopy, we obtain a sample that includes 16 likely members of Tri II, with up to 10 independent redshift measurements per star. To this multi-epoch kinematic data set, we apply methodology that we develop in order to infer binary orbital parameters from sparsely sampled radial velocity curves with as few as two epochs. For a previously identified (spatially unresolved) binary system in Tri II, we infer an orbital solution with period $296.0_{-3.3}^{+3.8} \rm ~ d$, semimajor axis $1.12^{+0.41}_{-0.24}\rm ~au$, and systemic velocity $-380.0 \pm 1.7 \rm ~km ~s^{-1}$ that we then use in the analysis of Tri II’s internal kinematics. Despite this improvement in the modelling of binary star systems, the current data remain insufficient to resolve the velocity dispersion of Tri II. We instead find a 95 per cent confidence upper limit of $\sigma _{v} \lesssim 3.4 \rm ~km~s^{-1}$.
First discoveries and localizations of Fast Radio Bursts with MeerTRAP: real-time, commensal MeerKAT survey
Authors: Rajwade K M , Bezuidenhout M C , Caleb M , Driessen L N , Jankowski F , Malenta M , Morello V , Sanidas S , Stappers B W , Surnis M P , Barr E D , Chen W , Kramer M , Wu J , Buchner S , Serylak M , Combes F , Fong W , Gupta N , Jagannathan P , Kilpatrick C D , Krogager J-K , Noterdaeme P , Núnẽz C , Prochaska J Xavier , Srianand R , Tejos N
Published: May 2022

We report on the discovery and localization of fast radio bursts (FRBs) from the MeerTRAP project, a commensal fast radio transient-detection programme at MeerKAT in South Africa. Our hybrid approach combines a coherent search with an average field-of-view (FoV) of 0.4 $\rm deg^{2}$ with an incoherent search utilizing a FoV of ∼1.27 $\rm deg^{2}$ (both at 1284 MHz). Here, we present results on the first three FRBs: FRB 20200413A (DM = 1990.05 pc cm−3), FRB 20200915A (DM = 740.65 pc cm−3), and FRB 20201123A (DM = 433.55 pc cm−3). FRB 20200413A was discovered only in the incoherent beam. FRB 20200915A (also discovered only in the incoherent beam) shows speckled emission in the dynamic spectrum, which cannot be explained by interstellar scintillation in our Galaxy or plasma lensing, and might be intrinsic to the source. FRB 20201123A shows a faint post-cursor burst of about 200 ms after the main burst and warrants further follow-up to confirm whether it is a repeating FRB. FRB 20201123A also exhibits significant temporal broadening, consistent with scattering, by a turbulent medium. The broadening exceeds from what is predicted for the medium along the sightline through our Galaxy. We associate this scattering with the turbulent medium in the environment of the FRB in the host galaxy. Within the approximately 1 arcmin localization region of FRB 20201123A, we identify one luminous galaxy (r ≈ 15.67; J173438.35-504550.4) that dominates the posterior probability for a host association. The galaxy’s measured properties are consistent with other FRB hosts with secure associations.
Extreme mass ratio inspirals and tidal disruption events in nuclear clusters – I. Time-dependent rates
Authors: Broggi Luca , Bortolas Elisa , Bonetti Matteo , Sesana Alberto , Dotti Massimo
Published: May 2022

In this paper, we develop a computationally efficient, two-population, time-dependent Fokker–Plank approach in the two dimensions of energy and angular momentum to study the rates of tidal disruption events (TDEs), extreme mass ratio inspirals (EMRIs), and direct plunges occurring around massive black holes (MBHs) in galactic nuclei. We test our code by exploring a wide range of the astrophysically relevant parameter space, including MBH masses, galaxy central densities, and inner density slopes. We find that mass segregation and, more in general, the time dependency of the distribution function regulate the event rate: TDEs always decline with time, whereas EMRIs and plunges reach a maximum and undergo a subsequent nearly exponential decay. Once suitably normalized, the rates associated to different choices of MBH mass and galaxy density overlap nearly perfectly. Based on this, we provide a simple scaling that allows to reproduce the time-dependent event rates for any MBH mass and underlying galactic nucleus. Although our peak rates are in general agreement with the literature relying on the steady-state (non-time-dependent) assumption, those can be sustained on a time-scale that strongly depends on the properties of the system. In particular, this can be much shorter than a Gyr for relatively light MBHs residing in dense systems. This warns against using steady-state models to compute global TDE, EMRI, and plunge rates and calls for a more sophisticated, time-dependent treatment of the problem.
Multiple variability time-scales of the early nitrogen-rich Wolf–Rayet star WR 7
Authors: Toalá J A , Bowman D M , Van Reeth T , Todt H , Dsilva K , Shenar T , Koenigsberger G , Estrada-Dorado S , Oskinova L M , Hamann W-R
Published: May 2022

We present the analysis of the optical variability of the early, nitrogen-rich Wolf–Rayet (WR) star WR 7. The analysis of multisector Transiting Exoplanet Survey Satellite (TESS) light curves and high-resolution spectroscopic observations confirm multiperiodic variability that is modulated on time-scales of years. We detect a dominant period of 2.6433 ± 0.0005 d in the TESS sectors 33 and 34 light curves in addition to the previously reported high-frequency features from sector 7. We discuss the plausible mechanisms that may be responsible for such variability in WR 7, including pulsations, binarity, co-rotating interaction regions (CIRs), and clumpy winds. Given the lack of strong evidence for the presence of a stellar or compact companion, we suggest that WR 7 may pulsate in quasi-coherent modes in addition to wind variability likely caused by CIRs on top of stochastic low-frequency variability. WR 7 is certainly a worthy target for future monitoring in both spectroscopy and photometry to sample both the short (≲1 d) and long (≳1000 d) variability time-scales.
Acoustic waves and g-mode turbulence as energy carriers in a viscous intracluster medium
Authors: Choudhury Prakriti Pal , Reynolds Christopher S
Published: May 2022

Many recent works on the observed galaxy clusters in the X-rays highlight broadly two classes of exclusive energy carriers – sound waves and turbulence. In order to understand this dichotomy, we design an idealized three-dimensional hydrodynamic simulation of a cluster, to assess which of these carriers can dissipate energy in and around the core (≳100 kpc). Specifically, we explore how gentle (long-duration outbursts) and intermediate (shorter duration outbursts) feedback modes can function efficiently mediated by compressible (sound waves) and incompressible (g modes/instabilities/turbulence) disturbances. Since g modes are confined tightly to the central core, we attempt to maximize the flux of fast sound waves to distribute the feedback energy over a large distance. We find that the contribution to heat dissipation from sound and turbulence varies on the basis of the aforementioned feedback modes, namely: turbulence contributes relatively more than sound in the slow-piston regime and vice versa for the intermediate regime. For the first time in a 3D simulation, we show that up to $\lesssim 20{{\ \rm per\ cent}}$ (in some directions) of the injected power can be carried away by sound flux in the intermediate feedback but it reduces to $\lesssim 10 {{\ \rm per\ cent}}$ (in some directions) in the slow-piston regime. Lastly, we find that sound waves can be elusive if we deduce the equation of state (isobaric/isentropic) of the fluctuations from X-ray observations.
Coordinated time variability of multi-phase ultra-fast outflows in J132216.25 + 052446.3
Authors: Aromal P , Srianand R , Petitjean P
Published: May 2022

We present a time variability analysis of broad absorption lines (BAL; spread over the velocity range of 5800–29 000 km s−1) seen in the spectrum of J132216.25 + 052446.3 (zem = 2.04806) at ten different epochs spanning over 19 yr. The strongest absorption component (BAL-A; spread over 5800–9900 km s−1) is made up of several narrow components having velocity separations close to C iv doublet splitting. The C iv, N v, and Si iv absorption from BAL-A show correlated optical depth variability without major changes in the velocity structure. A very broad and shallow absorption (BAL-C; spread over the velocity range 15 000–29 000 km s−1) emerged during our monitoring period coinciding with a dimming episode of J1322 + 0524. All the identified absorption lines show correlated variability with the equivalent widths increasing with decreasing flux. This together with the C iv emission line variability is consistent with ionization being the main driver of the correlated variability. The observed UV-continuum variations are weaker than what is required by the photoionization models. This together with a scatter in the C iv equivalent width at a given continuum flux can be understood if variations of the C iv ionizing photons are much larger than that of the UV continuum, the variations in the ionizing photon and UV fluxes are not correlated and/or the covering factor of the flow varies continuously. We suggest BAL-A is produced by a stable clumpy outflow located beyond the broad emission line region and BAL-C is a newly formed wind component located near the accretion disc and both respond to changes in the ionizing continuum.
Modelling the secular evolution of protoplanetary disc dust sizes – a comparison between the viscous and magnetic wind case
Authors: Zagaria Francesco , Rosotti Giovanni P , Clarke Cathie J , Tabone Benoît
Published: May 2022

For many years, protoplanetary discs have been thought to evolve viscously: angular momentum redistribution leads to accretion and outward disc spreading. Recently, the hypothesis that accretion is due, instead, to angular momentum removal by magnetic winds gained new popularity: no disc spreading is expected in this case. In this paper, we run several 1D gas and dust simulations to make predictions on the time evolution of disc sizes in the dust and to assess whether they can be used to understand how discs evolve. We show that viscous and magnetic wind models have very different dust disc radii. In particular, magnetohydrodynamic wind models are compact and their sizes either remain constant or decrease with time. On the contrary, discs become larger with time in the viscous case (when α ≳ 10−3). Although current observations lack enough sensitivity to discriminate between these two scenarios, higher sensitivity surveys could be fruitful to this goal on a $1\!-\!10\, {\rm Myr}$ age range. When compared with the available ALMA (Atacama Large Millimeter/submillimeter Array) Band 7 data, both viscous and magnetic wind models are compatible with the observationally inferred dust radii in Lupus, Chamaeleon I, and Upper Sco. Furthermore, in the drift-dominated regime, the size–luminosity correlation is reproduced in Lupus, both in Band 7 and 3, while in Upper Sco a different slope than in the data is predicted. Sub-structures (potentially undetected) can explain several outliers with large observed sizes. Higher angular-resolution observations will be helpful to test our predictions in the case of more compact discs, expected in both frameworks, particularly at the age of Upper Sco.
The impact of filaments on dwarf galaxy properties in the Auriga simulations
Authors: Zheng Haonan , Liao Shihong , Hu Jia , Gao Liang , Grand Robert J J , Gu Qing , Guo Qi
Published: May 2022

With a hydrodynamical simulation using a simple galaxy formation model without taking into account feedback, our previous work has shown that dense and massive filaments at high redshift can provide potential wells to trap and compress gas, and hence affect galaxy formation in their resident low-mass haloes. In this paper, we make use of the Auriga simulations, a suite of high-resolution zoom-in hydrodynamical simulations of Milky Way-like galaxies, to study whether the conclusion still holds in the simulations with a sophisticated galaxy formation model. In agreement with the results of our previous work, we find that, compared to their counterparts with similar halo masses in the field, dwarf galaxies residing in filaments tend to have higher baryonic and stellar fractions. At the fixed parent halo mass, the filament dwarfs tend to have slightly higher star formation rates than those of field ones. But overall we do not find a clear difference in galaxy g − r colours between the filament and field populations. We also show that at high redshifts, the gas components in dwarf galaxies tend to have their spins aligned with the filaments in which they reside. Our results support a picture in which massive filaments at high redshift assist gas accretion and enhance star formation in their resident dwarf-sized dark matter haloes.
Towards an understanding of YSO variability: a multiwavelength analysis of bursting, dipping, and symmetrically varying light curves of disc-bearing YSOs
Authors: Lakeland Ben S , Naylor Tim
Published: May 2022

Using simultaneous optical and infrared light curves of disc-bearing young stars in NGC 2264, we perform the first multiwavelength structure function study of YSOs. We find that dippers have larger variability amplitudes than bursters and symmetric variables at all time-scales longer than a few hours. By analysing optical-infrared colour time-series, we also find that the variability in the bursters is systematically less chromatic at all time-scales than the other variability types. We propose a model of YSO variability in which symmetric, bursting, and dipping behaviour is observed in systems viewed at low, intermediate, and high inclinations, respectively. We argue that the relatively short thermal time-scale for the disc can explain the fact that the infrared light curves for bursters are more symmetric than their optical counterparts, as the disc reprocesses the light from all rotational phases. From this model, we find that the accretion variability on to these YSOs roughly follows a random-walk.
A Population-Genetic Lens into the Process of Gene Loss Following Whole-Genome Duplication
Authors: Johri Parul , Gout Jean-Francois , Doak Thomas G , Lynch Michael
Published: May 2022

Whole-genome duplications (WGDs) have occurred in many eukaryotic lineages. However, the underlying evolutionary forces and molecular mechanisms responsible for the long-term retention of gene duplicates created by WGDs are not well understood. We employ a population-genomic approach to understand the selective forces acting on paralogs and investigate ongoing duplicate-gene loss in multiple species of Paramecium that share an ancient WGD. We show that mutations that abolish protein function are more likely to be segregating in retained WGD paralogs than in single-copy genes, most likely because of ongoing nonfunctionalization post-WGD. This relaxation of purifying selection occurs in only one WGD paralog, accompanied by the gradual fixation of nonsynonymous mutations and reduction in levels of expression, and occurs over a long period of evolutionary time, “marking” one locus for future loss. Concordantly, the fitness effects of new nonsynonymous mutations and frameshift-causing indels are significantly more deleterious in the highly expressed copy compared with their paralogs with lower expression. Our results provide a novel mechanistic model of gene duplicate loss following WGDs, wherein selection acts on the sum of functional activity of both duplicate genes, allowing the two to wander in expression and functional space, until one duplicate locus eventually degenerates enough in functional efficiency or expression that its contribution to total activity is too insignificant to be retained by purifying selection. Retention of duplicates by such mechanisms predicts long times to duplicate-gene loss, which should not be falsely attributed to retention due to gain/change in function.
A retrospective, longitudinal study of rheumatoid arthritis treatment patterns with Janus kinase inhibitors and other disease-modifying antirheumatic drugs in Japan
Authors: Kaneko Yuko , Sakurai Masaya , Snijder Robert , Kokubo Satoshi , Kato Daisuke
Published: May 2022

Objectives

There is limited information on the clinical use of Janus kinase inhibitors (JAKis) for rheumatoid arthritis treatment in Japan. The aim of this study was to identify disease-modifying antirheumatic drug (DMARD) treatment patterns in Japan.

Methods

This retrospective, longitudinal study extracted data from the Japan Medical Data Center database. Patients with rheumatoid arthritis diagnosis were enrolled 2016–19, during which patients had a first prescription of a major DMARD, split into six mutually exclusive classes: methotrexate (MTX); other conventional synthetic DMARDs; tumour necrosis factor alpha inhibitors; cytotoxic T-lymphocyte-associated antigen-4-immunoglobulin; anti-interleukin-6 receptor therapies; and JAKis. The primary objective was to describe DMARD treatment patterns, especially for JAKis.

Results

Overall, 10,399 patients were included in the analysis. The most common treatments were MTX, other conventional synthetic DMARDs, and tumour necrosis factor alpha inhibitors. The total number of JAKi prescriptions increased approximately 8-fold during 2016–19. Most (61.1%) patients who received JAKis had prior MTX or tumour necrosis factor alpha inhibitor treatment. The duration of JAKi treatment was longer than for biologics and other conventional synthetic DMARDs and comparable to that of MTX.

Conclusions

The sequence of drug class prescriptions for rheumatoid arthritis in Japan during 2016–19 followed clinical guidelines. Over this period, JAKis were increasingly used as a second-line treatment following MTX.