bluuebunny/crossref_metadata_2025 huggingface dataset:
Globalisasi dan Alienasi: Dampak Media Sosial Terhadap Keterasingan Manusia
Authors: Munajah Mumu , Agniawati Neneng Gina , Sari Suci Indah
Published: May 2023

Kehadiran media sosial dapat menciptakan alienasi pada penggunanya. Sebaliknya, alienasi dapat menjadi pemicu penggunaan media sosial yang berlebihan. Karena alienasi muncul bila hubungan sosial dengan orang lain kurang baik. Penelitian ini bertujuan untuk mengkaji alienasi pengguna yang merujuk pada mereka yang mencari tempat kenyamanan di mana mereka merasa dihargai dan didengarkan, khususnya melalui media sosial. Metode penelitian ini bersifat kualitatif dengan proses pengumpulan data secara literatur. Hasil penelitian ini bahwa media sosial bagi mereka yang mengalami alienasi hidupnya kembali mental serta rasa percaya diri, sekalipun berbincang dengan orang yang tidak dikenal secara langsung, namun hanya dengan tutur kata yang baik dan sopan mereka sudah bisa merasa didengarkan dan dihargai. Selain itu pula dampak baiknya seluruh masyarakat menjadi cepat tanggap melihat seluruh berita hangat yang disajikan media masa.
Deutsche feministische Außenpolitik: Auswirkungen für Afrika
Authors: Haastrup Toni
Published: May 2023

Die Einführung einer feministischen Entwicklungspolitik als Teil der neuen feministischen Außenpolitik der Bundesregierung kann zu einer positiven Neuausrichtung der deutsch-afrikanischen Beziehungen beitragen. Dieser Wandel wird jedoch davon abhängen, ob es gelingt, die Außenpolitik ganzheitlich an feministischen Ansätzen zu orientieren, um die Folgen von Rassismus und Kolonialismus ebenso in den Fokus zu nehmen wie die Ungleichheit der Geschlechter.
Environmental Noise - Integrating and sharing geographic data sets
Authors: Agência Portuguesa do Ambiente  , Antunes Cristina , Cunha Sofia , Baltazar Luís , Cruz Paulo
Published: May 2023

Noise is a major environmental concern. To address this issue, the European Commission (EC) launched the Environmental Noise Directive (END), whose main objective is to assess and manage noise from various sources, including airports, roads, railways and agglomerations. An effective implementation of END requires the harmonisation of data supplied by various national agencies such as municipalities and airport authorities. This paper presents the Portuguese approach to the harmonization of data, as part of the END implementation, which was coordinated by the Portuguese Environmental Agency (APA). It also describes a set of principles and procedures developed by APA to ensure data harmonization and integration in a single platform, which provides interoperable information to decision makers, key stakeholders and general public, through Web Services.
Datos espaciales públicos, Python y QGIS al servicio de la evaluación de impacto en salud en Andalucía
Authors: Fernández Álvarado Cristina , Moya Ruano Luis Ángel , Rodríguez Rasero Francisco Javier , Sanz Pérez Miguel
Published: May 2023

Mejores geodatos estadísticos implican mejores políticas y la experiencia de la Consejería de Salud de Andalucía es un ejemplo de ello. La incertidumbre en la disponibilidad de información precisa sobre el número y características de las poblaciones potencialmente afectadas por una intervención suele ser el mayor factor limitante de la efectividad de toda evaluación de impacto. Una de las claves del éxito de la implementación de la Evaluación de Impacto en la Salud (EIS) en Andalucía ha sido la disponibilidad de datos de población georreferenciada en cuadrículas que difunde el Instituto de Estadística y Cartografía de Andalucía. Estos datos permiten a la administración y a los agentes económicos y sociales afrontar los grandes retos que plantea la EIS: identificación y caracterización de la población vulnerable. La tecnología y el software libre han permitido dar un paso más allá, facilitando herramientas a la ciudadanía que faciliten esa caracterización y representación espacial de los indicadores necesarios para la elaboración de los informes de evaluación. Es en este contexto donde se ha desarrollado un complemento en QGIS mediante el lenguaje de programación Python que facilita la accesibilidad a los datos geoespaciales indicados y su posterior tratamiento
Normalización y geocodificación masiva de direcciones postales mediante procesos ETL y los servicios web del callejero digital de Andalucía unificado (CDAU)
Authors: Detry Geoffroy , Villarreal Piqueras Javier , López Flores Joaquín
Published: May 2023

El Inventario de Sedes y Equipamientos de la Junta de Andalucía (ISE) ofrece una visión global de la ubicación de los servicios prestados por la administración andaluza, ofreciendo tanto la localización geográfica como los datos alfanuméricos más relevantes de cada servicio. El ISE solventa los problemas asociados a la gran dispersión de datos y formatos en los que cada organismo responsable los publica, integrándolos en una única base de datos PostgreSQL/PostGIS normalizada que puede ser consultada mediante un visualizador web y servicios interoperables. Una de las tareas principales en el ISE es tratar la información de partida para que las direcciones postales sean normalizadas y que cada equipamiento o sede sea localizado a través de un punto geométrico. Estas operaciones (normalización y geocodificación), se ejecutan de forma automática utilizando el servicio WPS (Web Processing Service) del Callejero Digital de Andalucía Unificado (CDAU), fuente oficial de referencia de vías y portales en Andalucía. Para facilitar la tarea, las consultas han sido automatizadas dentro de flujos de trabajo implementados mediante la herramienta ETL Kettle, uno de los productos de la suite Pentaho Data Integration. Para ello, se invocan recursivamente las funciones de normalización y de geocodificación mediante el protocolo de comunicación REST y se interpreta la respuesta devuelta en formato JSON aislando los valores de interés (tipo de vía, nombre de vía, número de portal y juego de coordenadas) y generando las geometrías correspondientes.
O “AFFAIRE MARLON BUNDO” OU O PODER DA IDEOLOGIA NA LITERATURA INFANTIL
Authors: Machado Ana Maria
Published: May 2023

Marlon Bundo’s, A Day in the Life of the Vice President e A Day in the Life of Marlon Bundo são dois livros infantis destinados a crianças de 4-8 e 6-8 anos. Foram publicados nos Estados Unidos em 2018 por Charlotte Pence, filha do então vice-presidente republicano Mike Pence, e por Jill Twiss, respetivamente, sendo o último patrocinado pelo ativista democrata John Oliver. Com perspetivas políticas antagónicas, a primeira autora expressa uma visão tradicional e hierárquica do poder e a segunda defende os direitos LBGTQ. Apesar das suas diferenças, ambos os discursos verbais e iconográficos são ideológicos, l.s., na medida em que produzem afirmações sentenciosas destinadas a influenciar mais ou menos explicitamente a opinião de leitores incautos. O universo diegético de ambas as obras tende a ser fechado e destituído de complexidade, como se todas as soluções fossem definitivas e únicas. Neste artigo pretendo discutir como ambos os autores, republicanos e democratas, defendem e publicitam as suas mensagens com discursos semelhantes e como verbal e iconograficamente expressam as suas visões de forma a persuadir os possíveis destinatários.
AS CLASSES SECUNDÁRIAS EXPERIMENTAIS PELAS MEMÓRIAS DA IRMÃ MARIA LUIZA DE SION (1959-1962)
Authors: Fukushima Iasmin Emi Ferreira , Dallabrida Norberto
Published: May 2023

Esse artigo objetiva tratar da cultura escolar nas classes secundárias experimentais do colégio feminino católico Nossa Senhora de Sion de São Paulo, entre 1959 e 1962, pelas memórias da Irmã Maria Luiza de Sion, coordenadora das classes. Entende-se que os aspectos de tal cultura escolar são apropriações da Pedagogia Personalizada e Comunitária (PPC) do Padre Pierre Faure. Assim, investiga-se como os bens culturais disponíveis foram ressignificados e apropriados formando uma prática escolar renovada. Estudando a renovação do espaço e do tempo e o trabalho personalizado como aspectos de uma nova cultura escolar, entende-se de que forma a PPC foi apropriada, sendo resinificada pelas alunas e professores do colégio Sion. Entende-se que a PPC mobilizou as classes secundárias experimentais das décadas de 1950 e 1960 nos colégios católicos brasileiros. Conforme as memórias da Irmã Maria Luiza de Sion, o ensino tradicional deu lugar ao trabalho personalizado.
Upaya Peningkatan Manajemen Pelayanan Kesehatan Di Rumah Sakit: Tinjauan Teoritis
Authors: Astria Apriliavini Priscila Palenewen  , Dety Mulyanti
Published: May 2023

The hospital as a health service institution that organizes individual health services in a complete manner that provides inpatient, outpatient and emergency services. Efforts to improve health services as an agreement on setting long-term goals and visions which then become a common reference in achieving the goals that have been set. The purpose of this theoretical review is to find out how to improve health services in hospitals. The method used is a theoretical review by analyzing and comparing existing theories. The results of this theoretical review are by increasing efforts such as providing adequate infrastructure facilities including from a physical perspective, besides being efficient, fair, timely, secure, integrated, focused, reliable and effective. It can be concluded that efforts to improve the quality of health services as a process of meeting the needs and life expectancy of patients, both internally and externally. Quality can also be associated as a gradual and continuous improvement process. In general, the quality of health services focuses on the concept that health services have three main foundations, namely quality, access and cost.
Dampak Kualitas Pelayanan Terhadap Kepuasan Pasien Puskesmas: Studi Literature
Authors: M Hasyrul Muchtar  , Dety Mulyanti
Published: May 2023

Quality of service caused by human resources, facilities, and referrals that are not optimal. This study aims to determine the effect of service quality on patient satisfaction at the Puskesmas. This type of research is quantitative research with associative methods. The population in this study were all visitors who came to the Puskesmas. Sampling was done by purposive sampling technique. The mnumber of samples used in this study were 100 respondents. The data collection technique used was a questionnaire with a Likert scale. The analysis technique was carried out using multiple regression analysis using SPSS. The results of the study show that the tangible dimension has a significant influence on patient satisfaction, the reliable dimension has a significant effect on patient satisfaction, the responsiveness dimension has a significant influence on patient satisfaction, the assurance dimension has a significant influence on patient satisfaction, the empathy dimension has a significant influence on patient satisfaction. The most dominant dimension of influence is tangible, while the lowest is responsiveness. Tangible, reliable, responsiveness, assurance and empathy dimensions simultaneously have a significant influence on patient satisfaction. The results of the study are expected that the management of the Banja Loweh Community Health Center, Fifty Cities District, will further improve service quality, especially on the lowest responsiveness dimension.
Politik Dinasti Dalam Perspektif Hukum Ketatanegaraan Dan Filsafat Hukum
Authors: Danni Arthana
Published: May 2023

Demokrasi mengidealkan pergantian kekuasan tidak hanya terpsat pada satu kelompok dan golongan tertentu. Akan tetapi, pada prakteknya, baju demokrasi hanya digunakan dalam aspek formil-prosedural semata. Hal-jal yang bersifat substantif belum terlihat secara sempurna. Hal tersebut dapat tergambar dalam kekuasan yang tidak bergeser dari titik tertentu. Lingkaran kekuasaan tersebut terkonsentrasi pada sati ingkaran tertentu. Dalam penelitian ini, dinasti poltik tersebut dibedah dalam dua sudut pandang yang mendalam. Yakni dalam persepektif hukum tata negara dan filsafat hukum.
Aliran Hukum Sociological Jurisprudence Dalam Perseptif Filsafat Hukum
Authors: Koko Roby Yahya
Published: May 2023

Aliran hukum Sociological Jurisprudence merupakan aliran hukum yang ikut mengintervensi corak dan warna konfogurasi hukum. Baik dalam berbagai norma dan prakteak di lapangan. Oleh sebab itu, analisis terhadapa aliran ini dirasa sangat penting untuk melihat kelebihan dan kekungan dari aliran tersebut. Pendekatan yang dilakukan dalam diskursus ini adalah pendekatan kajian terhadap norma-noram yang ada beserta dengan konsep-konsep terkait yang berkelindan dengan aliran di atas. perspektif sociological jurisprudence tugas hakim dalam menerapkan hukum tidak melulu dipahami sebagai upaya social control yang bersifat formal dalam menyelesaikan konflik, tetapi sekaligus mendesain penerapan hukum itu sebagai upaya social engineering. Tugas yudisial hakim tidak lagi dipahami sekedar sebagai penerap undang-undang terhadap peristiwa konkrit (berupa berbagai kasus dan konflik) atau sebagai sekedar corong undang-undang (boncha de la loi) tetapi juga sebagai penggerak social engineering.
BUDAYA ORGANISASI BERPENGARUH POSITIF TERHADAP KINERJA KARYAWAN
Authors: Slamet Gunadi  , Shenina Adsila
Published: May 2023

Saat ini zaman mengalami perubahan dan perkembangan yang sangat pesat.  Dan kemajuan-kemajuan baik yang bersifat keilmuan maupun kebudayaan, telah memberikan manfaat yang sangat besar bagi kehidupan manusia. Di tengah-tengah kemajuan tersebut, iklim kompetisi (persaingan) baik yang bersifat pribadi hingga kolektif menjadi konsekuensi logis dari keinginan untuk maju dari pribadi-pribadi maupun dari kelompok-kelompok yang ada di lingkungan masyarakat. Persaingan yang terjadi ditunjukkan dengan banyaknya perusahaan-perusahaan yang muncul, berkembang, dan aktif dalam lingkungan sehari-hari, terutama dalam dunia bisnis. Persaingan yang semakin kompetitif, mendorong perusahaan untuk bersaing secara sehat merupakan hal positif bagi setiap perusahaan. Namun tidak selamanya persaingan sehat yang berjalan, sebab kadangkala muncul persaingan yang tidak sehat pula. Hal ini menjelaskan bahwa betapa ketatnya persaingan di dunia usaha.
The Effect of Knowledge Management on Employee Performance
Authors: Ermawati  Ermawati
Published: May 2023

This study aims to explain the effect of knowledge management on employee performance at Bank Madina Syariah Yogyakarta. The dependent variable in this study is employee performance. While the independent variable in this study is knowledge management on employee performance. The population in this study were all employees of Bank Madina Syariah Yogyakarta. The sampling method used was a saturated sample or all members of the research population. Data collection was carried out through distributing questionnaires and interviews. The analysis used is multiple linear regression technique. The results of the analysis show that knowledge management has a positive effect on employee performance.
Pengaruh Karakteristik Informasi Dan Sistem Informasi Akuntansi Terhadap Kinerja Manajerial Di Badan Penelitian Dan Pengembangan Provinsi Sumatera Barat
Authors: Lathiva Gusna Diva  , Elsa Meirina
Published: May 2023

This study aims to explain the influece of informatiomof characteristics and accounting information systems on managerial performance in goverment agencies is the aim of the research. Determination of the  sample using the total population sampling method in this study were structural officials and staff at the west sumatera research and development agency and the sample used in this study was as many as 31 respondents. Based on research result that there is an influence of information on characteristics on managerial performance the work of managers of geverments agencies and there is influence of accouting informatios systems on the managerial performance of agencies.
Integritas Guru Pak Dalam Membentuk Karakter Rohani Peserta Didik
Authors: Fitri Anggela
Published: May 2023

In writing this article the author discusses the integrity of PAK teachers in shaping the spiritual character of students. In this case the author will briefly explain the problems that occur for PAK students and teachers. There are still PAK teachers who have not been able to emulate Jesus' attitude, so they are unable to be role models for students. The integrity of an PAK teacher should be, namely directing the behavior of students so that they are successful in following lessons in a definite knowledge environment. In writing this article the author also provides implications for PAK teachers, namely: 1) maintaining the sanctity of his life as God's partner in educating and directing his students to become students like him; 2) realizing that he is a servant of God, the task of teaching is God's call, which must be taken seriously. Christian religious teachers must prepare lessons as well as possible; 3) Christian religious teachers must be role models and have integrity for students and be friendly to students in the context of building student character. Also the author uses a qualitative method of library research methods which is research that is synonymous with text analysis or lectures, where an event occurs either in the form of an activity or writing, which is examined to find out the real facts (to find out the real reasons etc.
Persembahan Yang Layak Di Hadapan Tuhan Ditinjau Dari Kejadian 4:1-16
Authors: Wasti Wasti  , Yublina kasse
Published: May 2023

Humans are basically spiritual beings. Because, a person can mentally react to something. Humans have always tried to relate to the divine. So the relationship with the god is in the form of worship. The concept of worship in both the Old and New Testaments is the same concept. The Hebrew word for century and the Greek for the beginning of latreia denote the occupation of slaves. And to perform "worship". Before Allah, then His servants must bow down in fear of adoration full of awe, awe and respect. This is the concept behind one's operation in every sacrificial activity in every ministry. Likewise with the implementation of public worship believing in the Lord Jesus. Human sacrifices given as thanksgiving offerings to God are part of worship. No after service offers. This is because the offer is not simply a symbol of giving with what one has, whether in money, or in kind, or in some other way. But the best thing about an offer is that to whom the offer is made the Lord Jesus must be based on faith or the right foundation of a gift from someone else or for some other purpose. Almost all forms of worship are carried out by Sunday schools for children, youth, youth, mothers, fathers, parents, Sunday services and other services bringing offerings of thanks for being part of the service. But the gift must be well understood and taken seriously.
Pengaruh Pengembangan Karir dan Kompensasi Terhadap Kepuasan Kerja Pegawai
Authors: Haris Nur Rahmi , Indar Sofyan Hamid
Published: May 2023

The purpose of this study was to determine the effect of partially and simultaneously on career development and compensation for job satisfaction of PT. Pos Indonesia Makassar Branch. With the number of samples in this study as many as 55 people with multiple regression analysis methods using SPSS.23 software. The findings in this study indicate that compensation is the dominant factor influencing job satisfaction. Partially career development and compensation have a positive and significant effect on job satisfaction and simultaneously career development and compensation have a positive and significant effect on job satisfaction.
Pengaruh Komunikasi dan Perencanaan Karir terhadap Kinerja Pegawai
Authors: Ilham Ilham , Hidayat Andi
Published: May 2023

The purpose of this study was to determine the effect of partial and simultaneous communication and career planning on employee performance, where the sample used in this study amounted to 120 employees, with multiple regression analysis techniques SPSS software approach 23. The results of this study indicate that communication has a negative and significant effect on employee performance and career planning has a positive and significant effect on employee performance, while for simultaneous testing there is a positive and significant effect of communication and career planning on employee performance.
Pengaruh Keandalan, Daya Tanggap dan Jaminan terhadap Kualitas Pelayanan Jasa Pengiriman Barang
Authors: Misi Hasrullah Liong
Published: May 2023

Penelitian ini bertujuan untuk menguji pengaruh antara keandalan, daya tanggap dan jaminan terhadap kualitas pelayanan. Populasi dalam penelitian ini adalah seluruh pelanggan PT. Ritra Cargo Indonesia. Adapun jumlah sampel pada penelitian ini adalah sebanyak 100 responden. Metode analisis yang digunakan adalah metode regresi linear berganda dengan bantuan software SPSS. Hasil penelitian ini menunjukkan bahwa keandalan tidak berpengaruh terhadap kualitas layanan, daya tanggap berpengaruh positif dan signifikan terhadap kualitas layanan, dan jaminan tidak berpengaruh terhadap kualitas layanan
Penerapan E-Billing dalam Persepsi Kemudahan Penggunaan
Authors: Munawara Munawara , Ramlah ST.
Published: May 2023

Tujuan penelitian adalah menganalisis faktor penyebab peningkatan penerapan e-billing oleh wajib pajak. Pendekatan yang digunakan dalam penelitian ini adalah penelitian kuantitatif. Sampel dalam penelitian ini adalah wajib pajak badan pada Kantor Pelayanan Pajak Pratama Makassar Barat. Penentuan sampel menggunaan metode purposive sampling. Hasil penelitian menunjukkan bahwa persepsi kemudahan penggunaan terhadap penerapan e-billing berpengaruh positif dan signifikan. Pengaruh tersebut dapat diketahui dari uji statistik regresi dimana diperoleh Y = 12,78 + 0,0913 X dengan pengaruh signifikan sebesar 26,59% dan nilai koefisien korelasi (r) sebesar 0,5157 berada dalam ketegori cukup kuat serta uji statistik inferensial. Penerapan e-Billing merupakan prosedur yang harus dilakukan dalam proses perpajakan, karena saat ini jika ingin membayarkan pajak harus memiliki kode Billing serta merupakan alat untuk memudahkan wajib pajak dalam melaksanakan kewajiban perpajakannya.
Pengaruh Transparansi Pelaporan Keuangan Terhadap Kepercayaan Dalam Mengelola Dana Zakat Infaq Dan Sedekah
Authors: Maming Rian , Sari Nispa
Published: May 2023

Abstrack: Zakat is one of the foundations of Islam that must be followed by all Muslims. The lack of understanding in paying zakat, so that the ability to collect zakat has not been maximized, transparency is needed in increasing trust in managing zakat infaq and alms funds. The type of data used in this study is quantitative data, namely data on the number of employees of the Palopo City Amil Zakat Agency. The analytical method of this research is the empirical method in the form of hypothesis testing (hypothesis testing). The results of this study are that transparency has a significant positive effect on Trust in Managing Zakat, Infaq and Alms, which means that if transparency is good, trust in managing ZIS will be good, and vice versa.

Keywords: Transparency ; trust

Abstrak: Zakat merupakan salah satu landasan Islam yang harus diikuti oleh semua umat Islam. Minimnya pemahaman dalam membayar zakat, sehingga kemampuan mengais zakat belum maksimal dibutuhkan transparansi dalam meningkatkan kepercayaan dalam mengelola  dana zakat infaq dan sedekah. Jenis data yang digunakan dalam penelitian ini adalah Data Kuantitatif, yaitu data jumlah karyawan Badan Amil Zakat Kota Palopo. Metode analisis penelitian ini yaitu metode empiris untuk dalam bentuk hypothesis testing (pengujian hipotesis). Hasil penelitian ini yaitu Transparansi berpengaruh positif signifikan terhadap Kepercayaan Dalam Mengelola Dana Zakat, Infak Dan Sedekah yang berarti bahwa jika transaparansi baik maka kepercayaan dalam mengelola ZIS akan baik, begitu pula sebaliknya.

Kata kunci: Transparansi; kepercayaan
Pengaruh Lingkungan Kerja Non Fisik dan Resiliensi terhadap Stress Kerja Anggota Korps Brigade Mobile
Authors: Muhammad Tang  , Faisal Faisal
Published: May 2023

The purpose of this study was to determine the influence of the work environment and resilience on the work stress of members of the South Sulawesi Regional Police Mobile Brigade Corps. This research was conducted with a quantitative approach and used multiple linear regression analysis to answer the hypothesis proposed. This study also involved 244 members of the South Sulawesi Regional Police Mobile Brigade Corps who served in Parepare City as respondents. The results of this study found that the work environment negatively affects work stress.  Resilience negatively affects the work stress of members of the South Sulawesi Regional Police Mobile Brigade Corps.
Analisis Rasio Profitabilitas dan Rasio Likuiditas Guna Menilai Kinerja Keuangan
Authors: Khaeruddin Faizah , Susanti Nur Arini , Rahman Yudi
Published: May 2023

This study aims to analyze the profitability ratios and liquidity ratios. Profitability ratios are calculated using ROA, ROE and ROI. And the liquidity ratio is calculated using the current ratio, cash ratio and quick ratio. Financial ratio analysis is an effective method for determining a company's financial performance, which includes both internal and external aspects, besides that financial analysis, serves to make a decision on a financial problem that occurs. So that there will be improvements in the performance of the future period. Based on the results of financial statement analysis, using Profitability Ratios and Liquidity Ratios, it was found that the Profitability and Liquidity ratios of Hotel Mira Wakatobi were still not good because they experienced fluctuations and decreased every year.
Resistance of the leather-rubber adhesive joint when making the shoe upper
Authors: Botić Tatjana , Bubić Sonja , Lakić Sara , Borković Aleksandra , Petrović Zoran
Published: May 2023

The professional literature dealing with specific aspects of adhesive joints in the footwear industry is mainly devoted to the procedures of preparation, bonding and testing of the connection between the upper and the sole material of fashion and sports footwear. However, there is little research related to the requirements and quality testing of adhesive joints of shoe upper parts. Safety and occupational footwear, which is intended for specific occupations such as firefighters, police officers, soldiers and others, as such has specific requirements in terms of resistance to various types of solvents, high and/ or low temperatures, shocks, etc., and in addition it should be comfortable and long-lasting. For these reasons, the upper of this type of footwear differs significantly from the footwear used in everyday life. It is usually a very complex construction and is made of a large number of different natural and artificial materials such as: leather, rubber, polyurethane, synthetic membranes, etc., which are interconnected by bonding or stitching. The aim of this study was to examine how the number of adhesive coatings and their characteristics affect the strength of the natural leather – rubber adhesive joint in the manufacture of shoes for special purposes. The strength of the leather-to-rubber adhesive joint depends significantly on the number of adhesive coatings and the viscosity of the adhesive.
Analysis of arsenic monitoring in underground water of the Republic of Serbia for 2018-2020
Authors: Plavšić Dunja , Isoski Dimitrije , Vidaković Ana
Published: May 2023

Arsenic is a heavy metalloid that occurs frequently in nature. The most serious repercussions for human health occur when it is found in drinking water (It can harm the circulatory, pulmonary, and nervous systems, as well as cause skin and other organs cancer). This paper presents the values of arsenic concentration in the Republic of Serbia's groundwater from 2018 to 2020, based on lab tests completed by the Serbian Environmental Protection Agency. Bearing in mind the fact that the Decree on Limit Values of Pollutants in Surface and Groundwater and Sediment and Deadlines for Reaching Them (Official Gazette of RS No. 50/12) does not prescribe limit values for arsenic in groundwater, as well as the fact that 75% of drinking water is supplied from groundwater, the results of testing the concentration of arsenic in groundwater are compared with the maximum allowed concentration of arsenic in drinking water prescribed by the Ordinance on the Hygiene of Drinking Water (Official Gazette of the FRY No. 42/98 and 44/99, Official Gazette RS No. 28/19). The concentrations of arsenic in eight piezometers were found to be above the maximum allowed concentration limit for drinking water for all three years. Having in mind the stated facts, it is necessary to update the regulations of the Republic of Serbia concerning the limit values of pollutants in groundwater, and to include the limit values for arsenic in it. The amendment of the regulation requires more detailed research regarding the concentration and origin of arsenic in groundwater.
Fast estimation method of optimal modal gain for adaptive optical system
Authors: Chen Ke-Le , Zhou Jia-Hui , Han Wen-Yu , Rao Xue-Jun , Guo You-Ming , Rao Chang-Hui ,   Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China,   Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China,   University of Chinese Academy of Sciences, Beijing 100049, China,   School of Electronic, Electrical and Commutation Engineering, University of Chinese Academy of Science, Beijing 100049, China,   National Key Laboratory of Optical Field Manipulation Science and Technology, Chengdu 610209, China
Published: May 2023

In an adaptive optical system, the optimal modal control method refers to applying proportional integral control of different bandwidths to the wavefront aberrations after modal decomposition to achieve better closed-loop results than the unified bandwidth modal control. The optimal modal gain usually needs to be obtained by ergodic solution based on the transfer function model of the adaptive optical system, the measured disturbance power spectral density, and the noise power spectral density, which usually takes a long time. Owing to the time-varying statistical characteristics of atmospheric turbulence, it is difficult to ensure the timeliness of the optimal modal gain. Therefore, we propose a method of fast estimating optimal modal gain based on quadratic polynomial fitting. In the method, it is only necessary to choose three reasonable gain coefficients and calculate their corresponding closed-loop residual errors respectively in order to estimate the optimal gain of single mode. The simulated slope data used in this work are cited from Lijiang 1.8 m adaptive telescope system, which consists of a 241-unit deformable secondary mirror and a Shaker-Hartmann wavefront sensor with 192 sub-apertures, with the first 135-order modes corrected by modal method. Our experiment is to test directly on-line on this system. The results show that under the same atmospheric environment, the proposed method can accurately estimate the optimal modal gain in a very short time and effectively suppress the high-order wavefront aberration. At the same time, owing to the reduced time complexity of the algorithm, the improved optimal modal gain estimation method takes only 0.33 s. Comparatively, it will take 7.08 s to obtain the optimal modal gain coefficient by using the parameter traversal method. Therefore the time spent on obtaining the optimal modal gain is shortened by about 95.3%, which is easier to meet the real-time requirements of the telescope, and beneficial to the adaptive optics system with more high-order modes. For the future adaptive optics system with more than one-thousand units, the proposed method can update the optimal gain to the second level, while the traversal method can only reach the minute level.
Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
Authors: Yong John , Villalta Jacqueline E , Vu Ngoc , Kukurugya Matthew A , Olsson Niclas , López Magdalena Preciado , Lazzari-Dean Julia R , Hake Kayley , McAllister Fiona E , Bennett Bryson D , Jan Calvin H
Published: May 2023

Protein aggregation increases during aging and is a pathological hallmark of many age-related diseases. Protein homeostasis (proteostasis) depends on a core network of factors directly influencing protein production, folding, trafficking, and degradation. Cellular proteostasis also depends on the overall composition of the proteome and numerous environmental variables. Modulating this cellular proteostasis state can influence the stability of multiple endogenous proteins, yet the factors contributing to this state remain incompletely characterized. Here, we performed genome-wide CRISPRi screens to elucidate the modulators of proteostasis state in mammalian cells, using a fluorescent dye to monitor endogenous protein aggregation. These screens identified known components of the proteostasis network and uncovered a novel link between protein and lipid homeostasis. Increasing lipid uptake and/or disrupting lipid metabolism promotes the accumulation of sphingomyelins and cholesterol esters and drives the formation of detergent-insoluble protein aggregates at the lysosome. Proteome profiling of lysosomes revealed ESCRT accumulation, suggesting disruption of ESCRT disassembly, lysosomal membrane repair, and microautophagy. Lipid dysregulation leads to lysosomal membrane permeabilization but does not otherwise impact fundamental aspects of lysosomal and proteasomal functions. Together, these results demonstrate that lipid dysregulation disrupts ESCRT function and impairs proteostasis.
Impairment of lipid homoeostasis causes accumulation of protein aggregates in the lysosome
Authors: Yong John , Villalta Jacqueline E. , Vu Ngoc , Kukurugya Matthew A. , Bennett Bryson D. , López Magdalena Preciado , Lazzari-Dean Julia R. , Hake Kayley , Jan Calvin H.
Published: May 2023

Protein aggregation increases during aging and is a pathological hallmark of many age-related diseases. Protein homeostasis (proteostasis) depends on a core network of factors directly influencing protein production, folding, trafficking, and degradation. Cellular proteostasis also depends on the overall composition of the proteome and numerous environmental variables. Modulating this cellular proteostasis state can influence the stability of multiple endogenous proteins, yet the factors contributing to this state remain incompletely characterized. Here, we perform genome-wide CRISPRi screens to elucidate the modulators of proteostasis state in mammalian cells using a fluorescent dye to monitor endogenous protein aggregation. These screens recovered components of the known proteostasis network, and uncovered a link between protein and lipid homeostasis. We subsequently showed that increased lipid uptake and/or disrupted lipid metabolism led to increased lysosomal protein aggregation and, concomitantly, accumulation of sphingolipids and cholesterol esters. Surprisingly, lysosomal proteostasis impairment by lipid dysregulation is independent of lipid peroxidation or changes in lysosomal stability, nor is it caused by effects on many other aspects of lysosomal or proteasomal function. These results suggest that lipid dysregulation may have primary effects on the stability of endogenous proteins, potentially through direct biophysical mechanisms.
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Authors: Bashkirova Elizaveta V. , Klimpert Nell , Pourmorady Ariel , Monahan Kevin , Campbell Christine E. , Osinski Jason M. , Tan Longzhi , Schieren Ira , Stecky Beka , Barnea Gilad , Xie X. Sunney , Abdus-Saboor Ishmail , Shykind Benjamin , Marlin Bianca Jones , Gronostajski Richard M. , Fleischmann Alexander , Lomvardas Stavros
Published: May 2023

Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we show that topographic restrictions in OR expression are established in neuronal progenitors by two opposing forces: polygenic transcription and genomic silencing, both of which are influenced by dorsoventral gradients of transcription factors NFIA, B, and X. Polygenic transcription defines spatially constrained OR repertoires, among which one OR allele may be selected for singular expression later in development. Heterochromatin assembly and genomic compartmentalization preferentially eliminate from this “privileged” repertoire ORs with more dorsal expression destinations, which are ectopically transcribed in neuronal progenitors throughout the olfactory epithelium. Our experiments identify early transcription as an “epigenetic” contributor to future developmental patterning and reveal how two spatially responsive probabilistic processes act in concert to establish deterministic, precise, and reproducible territories of stochastic gene expression.
Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation
Authors: Lu Jiansen , Zhang Jiahuan , Jiang Huaji , Hu Zhiqiang , He Lian , Yang Jianwu , Xie Yingchao , Wu Dan , Li Hongyu , Zeng Ke , Tan Peng , Xiao Qingyue , Song Zijing , Bai Xiaochun , Yu Xiao
Published: May 2023

Van Gogh-like 2 (Vangl2), a core planar cell polarity (PCP) component, plays an important role in polarized cellular and tissue morphology induction, growth development and cancer. However, its role in regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated in patients with sepsis and identify Vangl2 as a negative regulator of NF-κB signaling by regulating the protein stability and activation of the core transcription component p65. Mice with myeloid-specific deletion of Vangl2 (

Vangl2
ΔM

) are hypersusceptible to lipopolysaccharide (LPS)-induced septic shock. Vangl2 deficient myeloid cells exhibit enhanced phosphorylation and expression of p65, therefore, promoting the secretion of pro-inflammatory cytokines after LPS stimulation. Mechanistically, NF-κB signaling-induced-Vangl2 recruits E3 ubiquitin ligase PDLIM2 to catalyze K63-linked ubiquitination on p65, which serves as a recognition signal for cargo receptor NDP52-mediated selective autophagic degradation. Taken together, these findings demonstrate Vangl2 as a suppressor of NF-κB mediated inflammation and provide insights into the crosstalk between autophagy and inflammatory diseases.
Contraceptive use among reproductive-age females with disabilities in central Sidama National Regional State, Ethiopia: a multilevel analysis
Authors: Tenaw Zelalem , Gari Taye , Gebretsadik Achamyelesh
Published: May 2023

Background

Contraceptive use is an important and cost-effective intervention to prevent unwanted pregnancies. People with disabilities face discrimination when it comes to using contraception and are doubly burdened by unwanted pregnancies. However, the status of contraceptive use and associated factors among reproductive-aged females with disabilities was not adequately determined in Ethiopia.

Objective

This study aimed to assess contraceptive use and associated factors among reproductive-age females with disabilities in Dale and Wonsho districts and Yirgalem city administration of central Sidama National Regional State, Ethiopia.

Methods

A community-based cross-sectional study was conducted among randomly selected 620 reproductive-age females with disabilities living in the selected districts from June 20 to July 15, 2022. The data were collected through face-to-face interviewing techniques using a structured questionnaire. A multilevel logistic regression analysis model was employed to analyze the data. The adjusted odds ratio (AOR) with a 95% confidence interval (CI) was used to report the measures of associations.

Results

In this study, 27.3% (95% CI [23.8%–31.0%]) of the reproductive-age females with disabilities were current contraceptive users. Regarding the methods, 82 (48.5%) of the reproductive-age females with disabilities used implants. Having good contraceptive knowledge (AOR = 9.03; 95% CI [4.39–18.6]), transport accessibility to health facilities (AOR = 2.28; 95% CI [1.32–3.94]), being an adult (25 to 34 years old) (AOR = 3.04; 95% CI [1.53–6.04]), having a hearing disability (AOR = 0.38; 95% CI [0.18, 0.79]), having paralysis of the extremities (AOR = 0.06; 95% CI [0.03–0.12]), and wheel-chaired disability (AOR = 0.10; 95% CI [0.05–0.22]) were factors associated with contraceptive use.

Conclusion

Contraceptive use among reproductive-age females with disabilities is low. Transport accessibility, contraceptive knowledge, being in the age groups of 25 to 34 years, and the types of disability determine their contraceptive use. Therefore, designing appropriate strategies to provide contraceptive education and information and provide contraceptive services in their homes is important to enhance contraceptive use.
Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities
Authors: Khayat Maan T. , Ghazawi Kholoud F. , Samman Waad A. , Alhaddad Aisha A. , Mohamed Gamal A. , Ibrahim Sabrin RM
Published: May 2023

Depsidones are a class of polyphenolic polyketides that have been proposed to be biosynthesized from oxidative coupling of esters of two polyketidic benzoic acid derivatives. They are principally encountered in fungi and lichens. In addition to their diversified structural features, they revealed varied bioactivities such as antimicrobial, antimalarial, cytotoxic, anti-inflammatory, anti-Helicobacter pylori, antimycobacterial, antihypertensive, anti-diarrheal, antidiabetic, phytotoxic, anti-HIV, anti-osteoclastogenic, and butyrylcholinesterase, tyrosinase, hyaluronidase, and acetylcholinesterase inhibition. The current work was targeted to provide an overview on the naturally reported depsidones from various sources in the period from 2018 to the end of 2022 including their structures, biosynthesis, sources, and bioactivities, as well as the reported structure-activity relationship and semisynthetic derivatives. A total of 172 metabolites with 87 references were reviewed. The reported findings unambiguously demonstrated that these derivatives could be promising leads for therapeutic agents. However, furtherin-vivoevaluation of their potential biological properties and mechanistic investigations are needed.
Overview of patents of Federal Universities through patent quality metrics and impact on innovation from the database of the European Patent Office - PATSTAT EPO 2010-2020
Authors: Leonidio Ueliton da Costa , Pereira José Cristiano , De Souza Cristina Gomes , Cardoso Douglas de Oliveira , Julião Marcia da Silveira , Ferreira Humberto Medrado Gomes , Dos Santos Vanessa Cristina , Marques Ricardo Almeida
Published: May 2023

This study aims to provide a scenario and indicate the quality of patent registration in Brazilian federal universities from the database of the European Patent Office - EPO and PATSTAT between the years 2010 and 2020, considering the deposits, grants and other relevant data for research. The data were obtained in SQL language and were treated through data integration, supported by MS Power BI software, bringing contributions to the research profile in this international bank, such as the number of patents, research area profile, number of inventors, offices that received patent deposits, patent citations by family, geographic location, profile through patent classes, to understand the innovative process and pure invention, besides helping to improve processes, promote better partnerships, investments in more vital areas and to know the know-how of Universities in specific research areas. Finally, we note the 461-fold increase in the number of filings on this international base since 2015, indicating the maturity of Brazilian university patenting, and the concentration of universities in the Northeast, Southeast, and South. Based on the International Patent Classification (IPC), the most prominent areas are health, medical or veterinary clinics and hygiene (A61), representing 41.48% of the total number of patents, the area of microorganisms or enzymes, their compositions; propagation, conservation or maintenance of microorganisms, genetic or mutational engineering, culture media (C12), representing 12.29% of the total number of patents, the area of Food and food products (A23), microorganisms or enzymes; their compositions; propagation, preservation or maintenance of microorganisms represents 11.69% of patents, and area of organic chemistry (C07) represents 9.12% of patents and the area of investigation or analysis of materials by determining their chemical or physical properties (G01) which represents 6.18% of the total number of patents. The most prominent universities are UFPA, UFMG, UFPE, UFRGS, UFCE, UFPR, UFPEL, UFRN, UTFPR.
Peer Pressure and Motivation of Student Learning in Filipino: The Mediating Effect of Cooperative Learning
Authors: Fragata Laidee Dianne D. , Limpot Marilou Y.
Published: May 2023

Aims:  To determine the mediating effect of cooperative learning on the relationship between peer pressure and learning motivation in Filipino among students.

Study Design: Quantitative non-experimental design.

Place and Duration of Study: The study was conducted through online survey in a public school of Division of Davao del Surduring the school year 2021-2022.

Methodology: Therespondentswere290juniorhighschoolstudentsfroma public school in Division of Davao del Sur, Region XI, Southern Mindanao, Philippines. The selection of respondents was carried out through a stratified sampling technique. The data were collect edusing google forms.

Results: It was discovered that the independent variable peer pressure obtained a high level, as well as the independent variable student motivation in learning Filipino, and the mediating variable cooperative learning. It was also found that peer pressure and students' motivation in learning Filipino have a significant relationship, as well as peer pressure and cooperative learning, and cooperative learning and students' motivation in learning Filipino. Therefore, it appears that there is partial mediation occurring in this study.

Conclusion: It can be concluded that peer pressure had a significant effect on the decrease of students' motivation in the class, but with the help of cooperative learning, the significant relationship between the two aforementioned variables was reduced. In short, cooperative learning helps to reduce the negative effect of peer pressure on students' motivation to learn Filipino.The high level of cooperative learning in the relationship of peer pressure and student motivation in Filipino is a good indication that this is necessary to take place within the class such as group activities in which students have of exchanging ideas and working together to solve an academic problem.
Response of Biofertilizers and Molybdenum on Growth and Yield Attributes of Chickpea (Cicer arietinum L.)
Authors: Choudhary Dilip , Singh Rajesh
Published: May 2023

The field experiment entitled “Response of Biofertilizers and Molybdenum on Growth and Yield Attributes of Chickpea (Cicer arietinum L.)" was conducted during rabi, 2022 at Crop Research Farm in the Department of Agronomy, Naini Agriculture Institute, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj Uttar Pradesh. The experiment was layout in Randomized Block Design (RBD). The treatment consisted of three levels of Biofertilizer (Rhizobium, PSB and Rhizobium + PSB), Molybdenum (0.5, 1.0 and 1.5 kg/ha) and control. The soil in the experimental area was sandy loam with pH (7.8), Organic Carbon (0.43%), Available N (181.58 kg/ha), Available P (15.45 kg/ha) and Available K (197.64 kg/ha). Seeds are sown at a spacing of 30 × 10 cm to a seed rate of 80 kg/ha. The application of Rhizobium + PSB and Molybdenum 1.0 kg/ha significantly increased the Plant height (49.90 cm), No. of nodules/plant (32.60), Dry weight (35.33 g), Number of Pods/plant (60.20), Number of seeds/pod (1.80), Seed yield (1638.35 kg/ha) and Stover Yield (3539 kg/ha) of chickpea over the control.