bluuebunny/crossref_metadata_2025 huggingface dataset:
Atypical manifestation of familial laminopathy with simultaneous damage to the cardiac, muscle and peripheral nervous systems
Authors: Фомичева Ю.В. , Вершинина Т.Л. , Семенов А.П. , Костарева А.А.
Published: November 2020

Ядерные ламины являются основными белками ядерной оболочки и обеспечивают прочность ядерной мембраны и взаимодействие внеядерных структур с компонентами ядра клетки. Несмотря на большое количество исследований в данной области, нет единого мнения о механизме, лежащем в основе патогенеза ламинопатий. Мутации в гене ламина A/C являются причиной развития нескольких клинических фенотипов, как с изолированным вовлечением кардиальной, мышечной, жировой и костной тканей, так и с их сочетанием. Наиболее характерными клиническими проявлениями ламинопатий являются нарушения проводимости, желудочковые и наджелудочковые нарушения ритма, а также систолическая дисфункция миокарда. Среди пациентов, перенесших трансплантацию сердца, примерно 10% составляют пациенты с кардиомиопатиями, вызванными мутациями в гене ламина A/C. Часто доминирующая патология сердечно-сосудистой системы (ССС) может маскировать субклиническое вовлечение других тканей. Хотя сочетание кардиомиопатии с аритмическим расстройством и патологией скелетных мышц не является редкостью, о сопутствующем поражение периферической нервной системы сообщается не часто. В статье мы представляем случаи ламинопатии с различным вовлечением сердечной, мышечной и периферической нервной систем у членов одной семьи.

Nuclear laminates are the main proteins of the nuclear membrane and provide the strength of the nuclear membrane and the interaction of extranuclear structures with the components of the cell nucleus. Despite the large number of studies in this area, there is no consensus on the mechanism underlying the pathogenesis of laminopathies. Mutations in the lamin A/C gene are the cause of the development of several clinical phenotypes, both with isolated involvement of cardiac, muscle, adipose and bone tissues, and with their combination. The most characteristic clinical manifestations of laminopathies are conduction disorders, ventricular and supraventricular rhythm disturbances, as well as systolic myocardial dysfunction. Among patients who underwent heart transplantation, approximately 10% are patients with cardiomyopathies caused by mutations in the lamin A/C gene. Often, the dominant pathology of the cardiovascular system (CVS) can mask the subclinical involvement of other tissues. Although a combination of cardiomyopathy with arrhythmic disorder and skeletal muscle disease is not uncommon, concomitant damage to the peripheral nervous system is not often reported. In this article, we present family cases of laminopathy with various involvement of the cardiac, muscle and peripheral nervous systems among members of the same family.
Intermediate alleles of HTT gene in patients with Parkinson’s disease
Authors: Гомбоева Д. Е. , Брагина Е.Ю. , Никитина М.А. , Жукова Н.Г. , Алифирова В.М. , Назаренко М.С. , Пузырев В.П.
Published: November 2020

Болезнь Гентингтона (БГ) - нейродегенеративное заболевание, причиной которого является экспансия числа CAG-повторов в первом экзоне гена HTT. Превышение порога в 36 повторов приводит к БГ. Диапазон от 27 до 35 CAG-повторов составляют так называемые промежуточные аллели, которые, согласно последним данным, модифицируют клинические проявления нейродегенеративных заболеваний. В данном исследовании выявлено два случая носительства промежуточных аллелей с 27 CAG- повторами у пациентов с болезнью Паркинсона (БП). Анализ клинической картины выявил «нетипичность» клинического проявления БП. Таким образом, промежуточные аллели гена HTT оказывают модифицирующее влияние на течение БП.

Huntington’s disease (HD) is a neurodegenerative disease, caused by a CAG-repeat expansion in exon 1 of the HTT gene. The number of repeats more than 36 leads to HD. The range of 27-35 CAG-repeats is called as intermediate alleles (IAs). There is a growing evidence of importance of IAs for patients with other neurodegenerative diseases. In this study we have detected two cases of carriage of IAs in patients with Parkinson’s disease (PD). The analysis of clinical picture has revealed atypical clinical features of PD in these individuals. Thus, IAs of HTT gene may provide a modifying effect on clinical features of PD.
Analysis of mutations spectrum in the KCNQ1, KCNH2 and SCN5A genes in patients with long QT syndrome using massively parallel sequencing
Authors: Сивцев А.А. , Свинцова Л.И. , Плотникова И.В. , Жалсанова И.Ж. , Постригань А.Е. , Минайчева Л.И. , Джаффарова О.Ю. , Скрябин Н.А.
Published: November 2020

Проведен поиск мутаций в генах KCNQ1, KCNH2 и SCN5A методом массового параллельного секвенирования (МПС) у 10 пациентов из 8 семей с диагнозом «синдром удлиненного интервала QT» (СУИQT). Для пробоподготовки использована методика целевого обогащения участков ДНК, относящихся к исследуемым генам. В результате проведенной работы выявлено 8 мутаций: 5 из них расположены в гене KCNQ1, 2 мутации - в гене KCNH2, 1 мутация - в гене SCN5A. Во всех случаях были найдены уникальные мутации, не повторяющиеся у неродственных пациентов. Результаты проведенной работы указывают на эффективность использования таргетных панелей для поиска генетических аномалий при СУИQT.

We searched for mutations in the KCNQ1, KCNH2 and SCN5A genes using mass parallel sequencing (MPS) in 10 patients from 8 families with a diagnosis of “long QT syndrome” (LQTS). For sample preparation, we used the targeted enrichment of DNA regions method related to the studied genes. As a result of the work, 8 mutations were revealed: 5 of them are located in the KCNQ1 gene, 2 mutations in the KCNH2 gene, 1 mutation in the SCN5A gene. In all cases, we found unique mutations that did not recur in unrelated patients. The results of this work indicate the effectiveness of using targeted panels to search for genetic abnormalities in LQTS.
Personalized approach to drug therapy for multimorbid patients with left ventricular non-compaction cardiomyopathy
Authors: Блохина А.В. , Ершова А.И. , Мешков А.Н. , Киселева А.В. , Мясников Р.П. , Куликова О.В. , Зятенкова Е.В. , Скирко О.П. , Климушина М.В. , Сотникова Е.А. , Курилова О.В. , Покровская М.С. , Драпкина О.М.
Published: November 2020

Некомпактный миокард левого желудочка (НМЛЖ) характеризуется развитием ряда осложнений, что в сочетании с сопутствующими заболеваниями обычно приводит к полипрагмазии. Фармакогенетическое тестирование (ФГТ), направленное на выявление вариантов генов, ассоциированных с метаболизмом лекарственных препаратов (ЛП), может позволить подобрать наиболее эффективную и безопасную лекарственную терапию в каждом конкретном случае. В исследование было включено 16 больных с НМЛЖ, его осложнениями и другими заболеваниями. Всем пациентам проводилась оценка 60 однонуклеотидных полиморфизмов (SNP) с помощью полимеразной цепной реакции в реальном времени в амплификаторе QuantStudio 12KFlexReal-TimePCRSystem (ThermoFisherScientific, США). По результатам ФГТ выявлено 62,5% пациентов с НМЛЖ, генотипы которых ассоциированы с изменением метаболизма ЛП. У 12,5% пациентов в анамнезе прием ЛП, требующих коррекции дозы или замены на другой ЛП с учетом результатов ФГТ.

A left ventricular non-compaction cardiomyopathy (LVNC) is characterized by the development of a number of complications, which in combination with concomitant diseases usually leads to polypharmacy. Pharmacogenetic testing (PGT), aimed at identifying variants of genes associated with the metabolism of drugs, allows to choose the most effective and safe drug therapy in each case. The study includes 16 patients with LVNC, its complications and other diseases. All patients were assessed for 60 single nucleotide polymorphisms (SNPs) using real-time polymerase chain reaction in a QuantStudio 12KFlexReal-TimePCRSystem thermocycler (ThermoFisher Scientific, USA). According to the results of PGT 62.5% of the patients with LVNC and genotypes associated with a change in the metabolism of drugs were revealed. 12.5% of the patients had a history of taking drugs that required dose adjustment or replacement with another drug, taking into account the results of PGT.
Molecular and epigenetic mechanisms of the involvement of redox-homeostasis genes in the development of various cardiovascular diseases
Authors: Бушуева О.Ю. , Барышева Е.М. , Марков А.В. , Королёва Ю.А. , Чуркин Е.О. , Назаренко М.С. , Полоников А.В. , Иванов В.П.
Published: November 2020

В исследование были включены 1814 пациентов с артериальной гипертензией, ишемической болезнью сердца, мозговым инсультом и сочетанием этих заболеваний и 885 здоровых индивидов из Центральной России. Проведен молекулярно-генетический анализ 18 полиморфных вариантов генов редокс-гомеостаза (Р-Г) и анализ метилирования 4 генов Р-Г. Обсуждаются молекулярно-генетические и эпигенетические механизмы вовлеченности генов Р-Г в формирование распространенных сердечно-сосудистых заболеваний и их коморбидных форм.

A total of 1814 patients with arterial hypertension, coronary heart disease, cerebral stroke and a combination of these diseases and 885 healthy individuals from Central Russia were recruited for the study. Molecular genetic analysis of 18 polymorphisms of redox homeostasis (R-H) genes and analysis of methylation of 4 R-H genes were carried out. Molecular-genetic and epigenetic mechanisms of the involvement of R-H genes in the development of common cardiovascular diseases and their comorbid forms are discussed.
Association of polymorphisms of the KCNQ1 and ADIPOQ genes with the prognosis of type 2 diabetes
Authors: Мельникова Е.С. , Рымар О.Д. , Иванова А.А. , Мустафина С.В. , Шапкина М.Ю. , Bobak M. , Малютина С.К. , Ввоевода М.И. , Максимов В.Н.
Published: November 2020

Цель работы - изучение ассоциации однонуклеотидных полиморфизмов rs2237892 гена KCNQ1 и rs6773957 гена ADIPOQ с сахарным диабетом 2 типа (СД2). На основе проспективного обследования репрезентативной популяционной выборки жителей г.Новосибирска сформированы две группы по принципу «случай - контроль». Группа СД2 (n=443, средний возраст 56,2 лет, мужчины - 28,8%, женщины - 71,2%), группа контроля (n=532, средний возраст 56,1 лет, мужчины - 33,8%, женщины - 66,2%) сформированы из банка ДНК международного исследования HAPIEE. ДНК выделена методом фенолхлороформной экстракции. Генотипирование выполнено методом ПЦР с последующим анализом полиморфизма длин рестрикционных фрагментов. Статистическая обработка проведена с использованием программного пакета SPSS 16.0. По частотам генотипов и аллелей полиморфизмов rs2237892 гена KCNQ1 и rs6773957 гена ADIPOQ не выявлено статистически значимых различий между группами, в том числе и при разделении по полу и возрасту (p>0,05). Значимого влияния rs2237892 гена KCNQ1 и rs6773957 гена ADIPOQ на риск развития СД2 не обнаружено.

The aim of this work is study the association of rs2237892 and rs6773957 with T2D in a case-control study. Two groups was formed based on the case - control study. The T2D group is 443 person (mean age 56.2 years, men - 28.8 %, women - 66.2 %), the control group was selected according to the sex and age from the DNA bank of project Health, Alcohol and Psychosocial factors In Eastern Europe (HAPIEE) (n = 532, mean age 56.1 years, men - 33.8 %, women - 66.2 %). DNA was isolated by phenol-chloroform extraction. Genotyping was done by PCR followed by analysis of restriction fragment length polymorphism. Statistical processing was performed using the SPSS 16.0 software package. The genotypes frequencies of rs2237892 of the KCNQ1 gene and rs6773957 of the ADIPOQ gene did not show statistically significant differences. There was no significant effect of rs2237892 of the KCNQ1 gene and rs6773957 of the ADIPOQ gene on the risk of developing type 2 diabetes.
Value of genetic testing of herminal tumor mutations in screening and prevention of malignant formations
Authors: Буяновская О.А. , Бурменская О.В. , Гольцов А. Ю. , Кочеткова Т.О. , Шубина Е. , Мишина Н.Д. , Трофимов Д.Ю.
Published: November 2020

Проанализированы современные данные о роли генетического тестирования мутаций в генах, ответственных за предрасположенность к наследственному раку половых органов у женщин. Представлены данные о важности использования генетического тестирования в клинической практике для прогнозирования развития заболевания, необходимости последующего мониторинга при наличии мутационной нагрузки и выбора тактики комбинированной терапии при злокачественных новообразованиях

The authors analyzed available data in modern literature on the role of genetic testing for mutations in genes responsible for predisposing to hereditary cancers of reproductive organs in women. They are looking at data on the importance of using genetic testing in clinical practice to predict the disease development, need for follow-up monitoring in the presence of mutation load, and determination of combined chemotherapy policy for malignant neoplasms.
Advantages of high throughput parallel sequencing in detecting somatic mosaicism in sporadic retinoblastoma
Authors: Алексеева Е.А. , Бабенко О.В. , Козлова В.М. , Ушакова Т.Л. , Казубская Т.П. , Танас А.С. , Карандашева К.И. , Стрельников В.В. , Залетаев Д.В.
Published: November 2020

Почти 80% случаев наследственной ретинобластомы не имеют семейного анамнеза и возникают в результате мутаций de novo в гене RB1. Методом высокопроизводительного параллельного секвенирования (ВПС) проведено молекулярно-генетическое обследование 208 неродственных больных со спорадической РБ, среди которых 145 пациентов с унилатеральной формой заболевания и 63 - с билатеральной. В группе пациентов с билатеральной РБ молекулярные изменения в гене RB1 обнаружены в 90,5% (57/63) случаев. У 4,8% (3/63) пациентов определен мозаичный вариант мутации в гене RB1. В группе пациентов с унилатеральной РБ молекулярные изменения в гене RB1 выявлены в 17,9% (26/145) случаев. Среди исследованных пациентов соматический мозаицизм выявлен в 9,0% (13/165) случаев. Применение ВПС позволяет точно определять аллельную частоту вариантов, что делает поиск соматического мозаицизма эффективным.

Almost 80% of cases of hereditary retinoblastoma do not have a family history and arise as a result of de novo mutations in the RB1 gene. An NGS test was performed on 208 unrelated patients with sporadic RB, including 145 patients with a unilateral form and 63 patients with a bilateral one. In the group of patients with bilateral RB, pathogenic variants in the RB1 gene were detected in 90.5% (57/63) cases. In 4.8% (3/63) of patients, a mosaic variants were determined. In the group of patients with unilateral RB, changes in the RB1 gene were detected in 17.9% (26/145) cases. Among the examined patients, somatic mosaicism was detected in 9.0% (13/165) cases. NGS allows us to determine the allelic frequency of variants, which makes the search for somatic mosaicism effective.
Association of a combination of alleles and genotypes of polymorphic variants of matrix metalloproteinase genes and their tissue inhibitors genes with a risk of developing of gastric cancer
Authors: Галлямова Л.Ф. , Нургалиева А.Х. , Хуснутдинов Ш.М. , Сакаева Д.Д. , Хуснутдинова Э.К.
Published: November 2020

Проведен анализ распределения частот аллелей/генотипов полиморфных локусов rs1799750 и rs494379 гена MMP1, rs2285053 гена MMP2, rs3025058 гена MMP3, rs3918242 и rs17576 гена MMP9, rs2276109 гена MMP12, rs8179090 гена TIMP2 и rs9619311 гена TIMP3 у 314 пациентов с раком желудка, а также у 339 здоровых индивидов из Республики Башкортостан. С помощью алгоритма APSampler выявлены сочетания аллелей/генотипов, ассоциированные как с повышенным, так и с пониженным риском развития заболевания.

The analysis of the frequency distribution of alleles/genotypes of polymorphic loci rs1799750 and rs494379 of the MMP1 gene, rs2285053 of the MMP2 gene, rs3025058 of the MMP3 gene, rs3918242 and rs17576 of the MMP9 gene, rs2276109 of the MMP12 gene, rs8179090 of the TIMP2 gene and rs9619311 of the TIMP3 gene in 314 patients with gastric cancer, as well as in 339 healthy individuals from the Republic of Bashkortostan. Using the APSampler algorithm were identified combinations of alleles/genotypes associated with increased and reduced risk of developing the disease.
Somatic mutations in epigenetic regulation genes detected by NGS in gastric tumors
Authors: Немцова М.В. , Калинкин А.И. , Кузнецова Е.Б. , Алексеева Е.А. , Буре И.В. , Михайленко Д.С. , Танас А.С. , Стрельников В.В.
Published: November 2020

Эпигенетические механизмы регулируют структуру хроматина и создают устойчивые закономерности экспрессии генов в процессе жизни клеток. Нарушение эпигенетической регуляции играет значительную роль в канцерогенезе, инвазии, рецидивировании и метастазировании опухолей и может служить полезным клиническим маркером. Мутационное профилирование генов эпигенетической регуляции в опухолевых образцах рака желудка позволит определить новые клинические и прогностические маркеры и дополнительные таргеты для лечения пациентов. В статье представлены первые результаты исследования соматических мутаций в генах эпигенетической регуляции, проведенного методом NGS.

Epigenetic mechanisms regulate chromatin structure and create stable patterns of gene expression during cell life. Violation of epigenetic regulation plays a significant role in carcinogenesis, invasion, recurrence and metastasis of tumors, and can serve as a useful clinical marker. Mutational profiling of epigenetic regulation genes in tumor samples of gastric cancer will allow us to identify new clinical and prognostic markers and additional targets for the treatment of patients with gastric cancer. This article presents the first results of a study of somatic mutations in the epigenetic regulation genes carried out using NGS.
The results of the use of molecular genetic technologу for the diagnosis of tuberous sclerosis
Authors: Аношкин К.И. , Карандашева К.О. , Алексеева Е.А. , Кузнецова Е.Б. , Демина Н.А. , Гусева Д.М. , Танас А.С. , Залетаев Д.В. , Стрельников В.В.
Published: November 2020

Проведено комплексное молекулярно-генетическое обследование пациентов с диагнозом туберозный склероз. Комплекс включает высокопроизводительное параллельное секвенирование с глубоким покрытием для выявления точковых мутаций и инделов, MLPA для выявления протяженных делеций и секвенирование по Сэнгеру. В выборке из 202 пациентов мутации найдены в 96,5% случаев; из них точковые мутации и инделы - в 93,3%, а протяженные делеции - в 6,7%. В 5,9% были найдены мутации с низкой аллельной представленностью (мозаицизм).

A comprehensive molecular genetic examination of patients with diagnosis of tuberous sclerosis was carried out. The complex includes NGS with deep sequencing for detecting point mutations and indels, MLPA for identification of extended deletions, and Sanger sequencing. Mutations was found in 96,5% cases from 202 samples. Point mutation and indels were found in 93,3% cases, extended deletions were found in 6,7%. Mutations with low allelic representation were found in 5,9%.
Analysis of the physical status of HPV-positive patients with primary operable non-small cell lung cancer
Authors: Гаптулбарова К.А. , Цыганов М.М. , Ибрагимова М.К. , Родионов Е.О. , Певзнер А.М. , Литвяков Н.В.
Published: November 2020

Изучена возможная взаимосвязь между вирусом папилломы человека (ВПЧ) и возникновением рака легкого (РЛ). В настоящее время доподлинно не установлено влияние вирусной инфекции на течение данного злокачественного новообразования. Кроме этого, не существует работ на российской популяции о сравнении выживаемости вирус-позитивных и вирус-негативных пациентов с диагнозом РЛ.

The present study examined the possible relationship between human papillomavirus (HPV) and the occurrence of lung cancer (RL). Currently, the effect of viral infection on the course of this malignant neoplasm has not been established for certain. In addition, there is no work on the Russian population on comparing the survival of virus-positive and virus-negative patients with a diagnosis of RL.
A Quick Policy to Filter Reactions Based on Feasibility in AI-Guided Retrosynthetic Planning
Authors: Genheden Samuel , Engkvist Ola , Bjerrum Esben Jannik
Published: November 2020

A neural network-guided Monte Carlo tree search (MCTS) has been shown to be a promising algorithmfor computer-aided synthesis prediction. Here we train and investigate a filter policy that removesunfeasible reactions from the search. We investigate three different methods to generate negativedata that the filter policy model can be trained on, and we show that these methods arecomplementary to each other. Therefore the most robust model is one that combines all generatednegative data. The filter in itself is quick (< 0.1 s per prediction on average) but using the filter policyin the MCTS results in a doubling of the search time. However it only leads to a small reduction in thesuccess rate of finding synthetic routes (< 1%) and we are able show that using filter policy the MCTSalgorithm produce more promising routes, although the predicted routes are more complex. The filterpolicy has been integrated in the AiZynthFinder software.
Engender Persistent Organic Room-Temperature Phosphorescence by Trace Ingredient Incorporation
Authors: Ding Bingbing , Ma Liangwei , Huang Zizhao , Ma Xiang , Tian He
Published: November 2020

The trace impurities in pure organic phosphors were always ignored because the ultra-low content impurities were considered to hardly affect the luminescent properties. Evidences from corresponding reports and research have shown that impurities may greatly affect room temperature phosphorescence (RTP) in some crystalline compounds. To date, very few literatures have clearly study the role of impurities in RTP because of the difficulty in the separation and structure identification of impurities. Also no reports have focused on utilizing trace impurities to form new strategies for efficient RTP. For the first time, an impurity was isolated from 1-(4-bromophenyl)-1H-imidazole (1BBI) and structural identified, which was proved to be the key to RTP in 1BBI crystal. Neither purified impurity nor 1BBI matrix shown any detectable RTP. The impurity could light up the unusual ultralong RTP in matrix even at 0.01 mol% content. Inspired by impurity/matrix phosphorescence, a trace-ingredient-mediated bicomponent strategy was introduced for high phosphorescence quantum yield (QY, up to 74.2%) and extralong lifetime (up to 430 ms).Research Highlights of this work are including1. The study of impurities in organic luminescent materials, including phosphorescent materials, is rarely reported due to the great difficulty of separation, purification and structure characterization. This work not only separated, purified and structure identified the trace impurity in the system but also confirmed the fact that the impurity engenders the RTP. And the corresponding mechanism was proposed as well.2. Inspired by the role of impurities in RTP, this work proposed an effective strategy for the design and preparation of persistent organic RTP based on active ingredient incorporation. Seven compounds were screened out to conduct the bicomponent RTP system and achieved bright RTP with high QY (up to 74.2%) and extra-long lifetime (up to 430 ms)) RTP with tunable colors.3. Combining the dual emission of blue fluorescence and yellow phosphorescence, a bicomponent system achieved a bright white-light emission, which shows its outstanding application potential. The design concept and strategy of this work supplies an efficient approach to develop RTP by simply mixing the matrix with a trace amount of active ingredients. And the trace-ingredient-mediated bicomponent system is preferred for its high efficiency, color-tunable, low cost and easy to prepare properties, which will make important sense for facilely developing organic persistent RTP materials. This work will not only lead to a new understanding of persistent organic RTP but also develop a facile and effective strategy for RTP afterglow materials.
COVID-19 Pozitif Hastaya Hemşirelik Bakımı Veren Bir Hemşirenin Deneyimleri: Olgu Sunumu
Authors: BİRİMOGLU OKUYAN Canan , GÜNEŞ Elifnur , YEŞİLYURT Esra
Published: November 2020

Pandemiler, sağlık sistemi üzerinde büyük etkisi olan ve ciddi ölümlere neden olan önemli bir halk sağlığı sorunudur. Sağlık çalışanları içerisinde en büyük grubu oluşturan ve COVID-19 pandemisi sürecinde zor görevler üstlenen hemşireler, doğrudan hasta bakımı ve iyileşmesinde ve salgının kontrolünde etkin rol oynayan hayati insan kaynaklarıdır. Katlanarak büyüyen salgın süreci ancak hemşirelerin refahını artırılarak yönetilebilir ve virüsün sağlık sektörü içinde yayılma riski bu şekilde minimumda tutulabilir. Hemşireler sağlık, bakım ve destek hizmetlerinin koordinasyonunda kritik bir rol oynamaktadır ve salgınlara karşı mücadelede ön plandadırlar. Bu nedenle hemşireler hastane tarafından sağlık güvenliği sağlanarak iyi desteklenmelidir. Bu olgu sunumunda salgın sürecinde COVID-19 pozitif hastalara bakım veren bir hemşirenin karşılaştığı sorunlar ile ilgili duygu ve düşünceleri açıklanmaktadır.
UI界面设计之小翼智慧的商标设计案例分析
Authors: 孙 吉山
Published: November 2020

随着现代化科技和电子产品的不断发展和进步，UI设计显得越来越重要。笔者结合自身实际完成的UI设计案例，从UI设计的理念概述、小翼智慧的商标设计的理念、小翼智慧的商标设计的定位和小翼智慧的商标设计的形成过程等多角度来分析UI设计的过程和特点，对于UI设计实践和理念的探索和思考具有重要的意义。
浅析经营的本质——从顾客价值创造的角度
Authors: 张 庆林 , 李 润发
Published: November 2020

近段时间以来，房地产行业取得了巨大的发展，对中国国民经济的贡献值巨大。当前形势下，中国经济面临转型，这给众多的行业和企业经营带来机遇，也带来巨大的生存压力，越来越多的企业管理人员意识到，对企业的管理不能继续原有的模式，必须迎合时代转型的要求，转变经营思路。在这种背景下，论文结合当前的经济形态，从顾客的角度探讨企业的经营本质，为地产企业快速实现经济转型建言献策。
5G背景下绿色智慧酒店管理模式探究
Authors: 容 毅
Published: November 2020

随着中国经济的快速发展，中国越来越重视5G背景下绿色智慧酒店的管理工作。为了进一步的提升绿色智慧酒店管理质量，要根据实际情况了解当前酒店智慧化管理现状，在酒店中增添一些智慧化产品，以提升酒店的管理水平为基准。因此，论文主要针对5G背景下绿色智慧酒店管理模式进行简要分析，并提出合理化建议。
县文化馆在社区群众文化建设中发挥的作用探究
Authors: 邝 静
Published: November 2020

随着中国社会发展和经济水平不断提高，人们的经济收入和生活水平也不断提升。同时，人们对精神文化的需求也逐渐增长，开始寻求更加多元化的精神生活享受，社区群众文化的重要性也逐渐凸显，并逐渐成为中国特色社会主义精神文明建设的重要组成环节。县文化馆是实现中国地方区域性文化传承和人民群众提高文化传播受众和实现精神文化广泛推广的重要载体，其具有较强的公益性特点，对人民群众精神文化水平和思想觉悟都有着极高的促进作用。因此，县文化馆必须在社区群众文化建设当中充分发挥其引领和组织作用，切实满足人民精神文化需求，以此来促进社会和谐稳定发展与中华文化的传承。
新媒体艺术下动画分类制作与发展趋势研究
Authors: 王 玉山
Published: November 2020

随着新媒体技术的不断发展，动画的制作方法越来越丰富，如图片表情动画、二维长短片动画、三维模拟仿真动画、网络应用动画等，并且传播途径也越来越多。论文从新媒体艺术的概念和特点入手，讨论新媒体艺术下的动画分类，并分析新媒体艺术下动画制作的方法，最后对动画艺术的发展趋势进行展望。
“翻转课堂”教学模式在高职英语教学中的应用研究
Authors: 郭 江虹
Published: November 2020

“互联网+”的兴起推动了各个行业的创新发展，也给高职院校的英语教学改革带来了新的机遇和挑战。慕课、微课同“翻转课堂”相结合的多元化英语教学模式的构建和基于APP的互动性英语学习模式的构建，有利于培养学生的自主学习和合作学习能力，培养学生的批判性思维能力，提高高职英语教学的效果和质量。
探究新课改下小学数学教学方法的创新
Authors: 卢 文镜
Published: November 2020

在当前新课程改革工作背景下，小学教学体制当中数学教学工作所受重视程度越来越高，在实际教学时教学方法也在不断创新，从传统教学方法逐渐向现代化教学方法进行转变。数学教学主要是对学生思维能力进行提升，在新课程改革工作背景之下，数学教学工作需要充分发挥学生的自主性，并以此来制定教学方法，实现教学工作的全面创新与改革。在新课程改革工作背景下，论文针对小学数学教学方法的创新工作进行论述。
基于中国高教改革的高等教育扩招政策对学生发展影响的思考与建议
Authors: 强 乐颖
Published: November 2020

世纪之交的高等教育扩招政策作为21世纪中国高等教育改革的指导文件，对社会、经济、教育和学生发展有着至关重要的影响。论文旨在探讨中国高等教育扩招政策对高校学生的影响以及对扩招政策实施中所产生的问题的改进提供建议。不可否认，中国的高等教育扩张政策确实对学生的发展产生了显著的影响，尤其是在专业发展、就业和幸福感方面，然而该政策在其实施的过程中所产生的问题也不容忽视。论文从教育质量、就业压力、学生幸福感等方面入手，对这些问题提出具体的建议。有效地了解该政策的影响以及学生对高等教育的需求，都有利于中国高等教育的不断完善，更能重视学生的发展，也可以为中国未来的教育政策和改革提供意见和建议。
Information and communication technologies: foreign experience and national model
Authors: Yanchuk V. A.
Published: November 2020

The 21st century is characterized by the formation of an “intellectual nation” as a new direction of modernization of modern society; at the same time, the intellectual personality acts as a factor of socio-economic development. The most important task for Kazakhstan is the implementation of the Strategic Objective, where an important area is complete modernization in the socio-economic sphere. This task is also typical for a number of developing countries of the world, where the key aspect in the modernization of society is the creation of new innovative institutions to rethink and recreate the modern socio-economic formation. Modernization extends to areas such as intellectual work associated with the new division of labor; as a scientific and cultural sphere related to the knowledge economy and the new information society. Science is faced with a new task to solve the problem of forming an intellectual society, which implies the need for active interdisciplinary research, the integration of socio-humanitarian and socio-political sciences. Kazakhstan, like other developing countries, is faced with the strategic task of becoming a society of the future, in which the basis of the new economy is intellectual potential, a highly competitive system of higher education and an innovatively advanced socio-cultural infrastructure. At the present stage of development of the socio-economic formation, higher education successfully corresponds with the economic sector, and human resources are the main value that makes an innovative contribution to the creation of new products in industry, science, culture and other sectors of the economy and social sphere. In this regard, an important mission of higher education in Kazakhstan is to train highly competitive, innovatively advanced specialists who are able to think creatively and work as highly professional personnel of Kazakhstani society. Key words: intellectual nation, mass media, informational development, intellectual society, partners.
INFORMATION PROVISION OF INVESTMENT PROCESSES IN THE REPUBLIC OF UZBEKISTAN
Authors:   Tashkent Institute of Architecture and Construction of the Republic of Uzbekistan, Qahramonov Xurshidjon
Published: November 2020

At present, the influx of investments is becoming directly dependent on how the mechanisms of administrative, infrastructural, financial and information support of investment activities are formed. For investors, complete and reliable information, first of all, is a condition for reducing the risks of uncertainty when making investmentdecisions
PROBLEMS OF BUSINESS DEVELOPMENT IN UZBEKISTAN
Authors:   Yangiyer branch of the Tashkent Institute of Chemical Technology of the Republic of Uzbekistan, Qarshieva Nargiza
Published: November 2020

In this article, the main problems of business entities operating in Uzbekistan are: the length of the period for obtaining a building permit for business entities in Uzbekistan;long process of obtaining bank loans; it has been studied that connecting to power grid stakes more time than other countries in the world.
Study of the effect of the selected calculation methods on theoretical calculated flow capacity
Authors: Abdrazakov Fyarid  Kinzhaevich , Mikheeva Olga Valentinovna , Serebrеnnikov Fedor  Vasilievich
Published: November 2020

Depending on the chosen calculation method, the obtained throughput rate changes. The article discusses a number of methods for calculating the throughput of a square section, changing its value, depending on the chosen technique.
Evaluation of the efficiency of production of meat products for herodietic nutrition using beef produced from cross-bred Kazakh white-headed bulls
Authors: Gorlov Ivan Fedorovich , Nikolaev Dmitriy Vladimirovich , Zabelina Margarita Vasilievna , Semivolos Aleksandr  Mefodyevich , Bozhkova Svetlana  Evgenievna , Levina Tatiana Yurievna , Zvorygina Anna Sergeevna
Published: November 2020

The article is devoted to the development of functional meat food products made from beef obtained from crossbred steers when crossing red steppe cows with Kazakh white-headed bulls. The possibility of introducing a biologically active additive in the form of lactulose powder, as well as vitamins and minerals into the recipe of ham products is considered. To conduct research, raw meat-beef - was obtained from cross-bred steers of the same blood type on the Kazakh white-headed breed (PZK named after Lenin of the Surovikinsky district of the Volgograd region). At the same time, 3 samples of meat raw materials were selected in five-fold repeatability. The highest quality indicators were obtained by introducing lactulose in combination with ascorbic acid and calcium citrate into the recipe of sausage products. The economic efficiency of meat production is also higher for this recipe.
The Language of Advertising: Graphic, Grammar and Pragmatic Aspects
Authors: Panteleev Andrey , Inos Anastasija
Published: November 2020

This monograph deals with the problem of functioning peculiarities of graphic expressive means and grammar means in the language of modern Russian advertising. This research work treats the advertising discourse as a composite indirect speech act. Active use of adverbial modifiers of manner — deverbatives, elliptical and indefinite personal one-member sentences is characteristic of modern advertising texts. A most distinguishing feature of a modern advertising text is a mixture of Cyrillic and Latin fonts that contributes to the manifestation of an expressive potential of the application. The monograph is aimed at students of Philology, students major in Management and Marketing, masters, postgraduates, staff of higher educational establishments and all those who are interested in the Russian language.
EFFECTIVENESS OF E - CONTENT ON ACHIEVEMENT IN CHEMISTRY AMONG XI STANDARD BOYS
Authors: Subramanian P. , Ramakrishnan N.
Published: November 2020

An innovative application of computer in the teaching and learning process is e-content. This includes text, video, audio, animation and graphics. e-content is the advancement of technology to design, deliver, select, administer and extend learning. e-content in education is a powerful tool that may be used effectively and efficiently within the classroom to create more exciting learning environment and deliver a higher level of educational expertise to students. The present experiment brings out a clear-cut idea about the effectiveness of teaching Chemistry through e-content on the XI Standard boys achievement in Chemistry. The present study reveals that The XI Standard boys in experimental groups of both PPT design and PT design have excelled in e-content on Chemistry (atomic structure) than control groups which had gone through Chemistry (atomic structure) in traditional method in both PPT design and PT design.
Yeni Geliştirilen NUMEXO2 Dijital Elektronik ile EXOGAM2 Dedektörünün K-Parametresine Bağlı Enerji Çözünürlüğü
Authors: BOZKURT Vakkas , ERTURK Sefa , ŞAHİN Elif
Published: November 2020

Bu çalışmada, yeni geliştirilen dijital elektronik NUMEXO2 dijital elektronik ile EXOGAM2(EXOtic GAMma array spectrometer) dedektörünün K-Parametrelerine (sayım oranını optimize eden Trapezoidal filtre sistemi) bağlı enerji çözünürlüğü için 152Eu radyoaktif kaynak kullanılarak ölçüm ve analiz yapılmıştır. Yapılan bu deneysel çalışma Fransa’da bulunan GANIL (Grand Accelerature National d’Ions Lourd) nükleer araştırma merkezinde gerçekleştirilmiştir. Düşük ve yüksek gama enerji seviyesine sahip 152Eu radyoaktif kaynak kullanılarak farklı K-parametreleri için gerçekleştirilen ölçüm ve analiz sonuçları iki EXOGAM2 dedektörü için gerçekleştirilmiştir. Herhangi bir K-parametresi uygulamadan 1.EXOGAM2 dedektörü için FWHM ile ifade edilen çözünürlük değerleri sırası ile (344. 2785 keV) için 2.360% FWHM, (1408.006 keV) için 2.820% FWHM olarak ölçülürken 2.EXOGAM2 dedektörü için ise sırasıyla 2.451% FWHM ve 2.975% FWHM olarak ölçülmüştür. Farklı K-parametreleri (K=2µs, K=5µs ve K=10µs) için ise sonuçlar detayları ile aşağıda gösterilmiştir.
CMS HF Dedektöründe Kullanılan Fiberlerin Radyasyondan Gördüğü Zararı Görüntüleme Sistemi
Authors: GÜLER Yalçın
Published: November 2020

İleri Hadron (HF) dedektörü, Compact Muon Solenoid (CMS) deneyinin her iki yanında bulunup, CMS'nin çok ileri bölgedeki pseudorapidite (3.0 < | η | < 5.0) aralığını kapsar. Her bir HF modülü, demir soğurucuların uzunluğu boyunca ışın demeti eksenine paralel uzanan kuvars liflerinden yapılmıştır. HF, ışın eksenine yakın olduğu için yüksek düzeyde radyasyona maruz kalır. Ve yüksek radyasyon etkisi nedeniyle, kuvars fiberler zamanla bozulmaya başlar. Bu radyasyon etkisini belirlemek için HF detektörüne bazı özel fiberler yerleştirilmiştir. Radyasyonun neden olduğu hasarı izlemek için toplam 56 fiber kanalı kullanılmıştır. Bu çalışma, HF'nin radyasyon hasarının izlenmesi için 2010 yılı çalışma döneminde alınan yerel lazer verileri kullanılarak yapılmıştır. Belirli bir pseudorapidite ve azimutal açıda RadDam kanallarında önemli bir radyasyon hasarı gözlenmemiştir.
Penerapan Project Based Learning dengan Pendekatan STEM dalam Upaya Meningkat Kemampuan Menyusun Program CNC Pada Kelas XI Teknik Pemesinan SMK Negeri 3 Mataram
Authors: Muhaimin Anwar
Published: November 2020

Penelitian ini bertujuan untuk mengetahui pengaruh penerapan pembelajaran project based earning dengan pendekatan STEM terhadap peningkatan kemampuan siswa kelas XI Teknik Pemesinan SMK Negeri 3 Mataram dalam menyusun program CNC pada mata pelajaran Teknik Pemesinan CNC. Penelitian ini merupakan penelitian tindakan kelas dengan menerapkan tiga siklus. Pengukuran kemampuan menyusun program CNC menggunakan  empat yaitu kemampuan menyusun kepala program, kemampuan menyusun parameter-parameter pemrograman, kemampuan menyusun kode G dan kode M, dan kemampuan menyusun addres-address pemrograman. Hasil penelitian menunjukkan bahwa pada indikator menyusun kepala program terdapat 100% siswa yang mencapai nilai ketuntasan belajar baik pada siklus pra tindakan, siklus I maupun siklus II. Pada indikator menyusun parameter-parameter pemrograman, siswa yang mencapai nilai ketuntasan belajar terdapat 50 % pada siklus pra tindakan, 70% pada siklus I, dan 95% pada siklus II. Pada indikator menyusun kode G dan kode M, siswa yang mencapai nilai ketuntasan belajar terdapat 15 % pada siklus pra tindakan, 65 % pada siklus I, dan 82% pada siklus II.  Pada indikator menyusun address-address pemrograman, siswa yang mencapai nilai ketuntasan belajar terdapat 0 % pada siklus pra tindakan, 55 % pada siklus I, dan 80% pada siklus II
Spontaneous pneumomediastinum associated with COVID-19: Rare complication of 2020 pandemic
Authors: Arnaldo A Nieves-Ortiz , Vanessa Fonseca-Ferrer , Kyomara Hernández-Moya , Keren Mendez Ramirez , Jose Ayala-Rivera , Marangely Delgado , Juan Garcia-Puebla , Rosangela Fernández-Medero , Ricardo Fernandez-Gonzalez
Published: November 2020

Spontaneous pneumomediastinum (SPM) is a rare condition, more commonly seen in patients with history of asthma, chronic obstructive pulmonary disease, infections, or drug users. Today, we face one novel virus that has cause an outbreak of acute respiratory illness, affecting over a million individuals worldwide. New knowledge is been gained of the virus and possible complications are been seen. Following, we present the case of a 71-year-old man with diagnosis of COVID-19 pneumonia complicated with spontaneous pneumomediastinum.
SPATIAL DIVERSITY OF ENTREPRENEURSHIP IN COMMUNES OF THE ŚWIĘTOKRZYSKIE VOIVODSHIP IN 2009-2017
Authors: Dziekański Paweł , Lipa Adrian , Novoseletska Anna
Published: November 2020

The region includes a part of the economic space separated from the environment that is developed by a given community and interrelated economic entities. Owned territorial capital means that regions differ in the scale of entrepreneurship. The purpose of the article is to analyze and evaluate the spatial diversity of entrepreneurship in municipalities using a synthetic measure. The analysis was made in the system of 102 rural communes of the Świętokrzyskie Voivodship. The source material was data from the Local Database of the Central Statistical Office for 2009-2017. In analyzing the diversity of entrepreneurship in communes of the Świętokrzyskie Voivodship, synthetic measure based on the TOPSIS method was used. In 2017, TOPSIS's synthetic measure of entrepreneurship ranged from 0.39 (Waśniów (2)) to 0.81 (Kielce (1)). The best group includes units with an industrial function and a developing labor market, a developed tourist or spa function. The group of Kielce (1), Sandomierz (1), Skarżysko- Kamienna (1) and Ostrowiec Świętokrzyski (1), as the leading units in the analyzed period, is also indicated by gravity analysis (indicating the concentration of the phenomenon in the central region of the region). As a result of the analysis, it has been established that the condition for creating growth is the creation of permanent spatial systems resulting from the activities of enterprises. In the short term, enterprises generate local economic growth.
A SOCIAL STATE IN THE COUNTRIES OF CENTRAL EASTERN EUROPE AND IN UKRAINE: ECONOMIC AND POLITICAL FACTORS
Authors: Silenko Alla , Bezrodna Vira , Lyasota Lyudmyla
Published: November 2020

The subject of the research is the economic and political factors of the welfare state in the countries of Central and Eastern Europe and in Ukraine. Methodology. The work used a comparative approach, which made it possible to study the development of social states in Central and Eastern Europe, in Ukraine, to identify their similarities and differences. The institutional approach made it possible to consider the problem as a multidimensional socio-political phenomenon, to highlight functionally and systemically important elements and to study their mutual influence. Results. The purpose of the article is to analyze the prospects of the welfare state in the countries of Central and Eastern Europe and Ukraine, the influence of political and economic factors on its development. To achieve this goal, the following research tasks were set: to consider the issue of the influence of democracy on economic and social development; analyze the role of the state in socio-economic processes; to study the experience of socio-economic reforms in the countries of Central and Eastern Europe, which began their reforms almost simultaneously with Ukraine, and to find out why the success of their reforms is much higher than those achieved in Ukraine; clarify the reasons for the failure of reforms in Ukraine. It is shown that democracy does not affect economic growth; at the same time, democracy is the guardian of economic and social stability. It is substantiated that the welfare state provides citizens with protection that they will never receive from the state: the “night watchman”. As world experience has shown, the market does not guarantee the protection of the economy from crises and is not a panacea for eliminating the consequences. Sometimes, the market can even pose a threat to society, for example in the field of ecology. Thus, the actions of market forces and the interests of society do not always coincide. It is argued that the idea of a stable causal relationship between the reduction in the state’s participation in the redistribution of national income and an increase in economic growth is erroneous. Failures of economic and social reforms in Ukraine are explained by the fact that their liberal version was chosen, the consequences of which can be characterized as catastrophic. The low level of professionalism of reformers and corruption also played a negative role.
PROTECTION OF PROPERTY RIGHTS: SIDE EFFECTS OF ECONOMIC CRIME INVESTIGATION
Authors: Yanovska Oleksandra , Vilhushynskyi Mykhailo , Bitsai Anna
Published: November 2020

In the democratic countries, one of the main properties of public policy is to ensure the functioning of a stable economy; it requires special attention to the investigation and prevention of economic crime. However, the economic crime investigation can cause certain side effects, such as restriction or deprivation of property rights of individuals and legal entities. That is why the analysis of the peculiarities of the protection of property rights in the economic crimes investigation is particularly relevant. The purpose of the research is to generalize approaches for understanding the economic crime's nature and structure, analysing effective ways to protect property in the economic crimes investigation, as well as the specifics of releasing property from arrest as a way to protect third party property violated in the economic crimes investigation. Materials and methods: a set of general and special scientific methods was used in a study, in particular, the dialectical method; comparative legal method; methods of analysis and synthesis; formal logical (dogmatic) method; statistical method and generalization method. The empirical basis of the study is the cases of the Supreme Court (Ukraine) and the European Court of Human Rights, statistics of the State Judicial Administration of Ukraine for 2017-2019, as well as the authors' own experience as judge of the Supreme Court and the High Specialized Court of Ukraine for Civil and Criminal Cases. Results: there are two main approaches to understanding the essence of the concept of “economic crime” defined, its main features are identified and the system of economic crimes in Ukraine is characterized. It is argued that the application of such types of punishment for serious and especially serious profit-motivated crimes as special confiscation and confiscation of property is consistent with the practice of the ECHR. The case law of the Grand Chamber of the Supreme Court on determining the jurisdiction of legal disputes on the release of distrained property, used in the investigation of economic crimes, is summarized. Conclusions: for correct protection of the property rights of individuals and legal entities violated during the investigation of economic crimes, the state must ensure the proper functioning of effective legal means of protection of property rights.
Metode Boost-K-means untuk Clustering Puskesmas berdasarkan Persentase Bayi yang Diimunisasi
Authors: Abdullah Ahmad Irfan , Winarko Edi , Musdholifah Aina
Published: November 2020

Dinas Kesehatan Kabupaten/Kota adalah satuan kerja pemerintahan daerah kabupaten/kota yang bertanggung jawab menyelenggarakan urusan pemerintahan dalam bidang kesehatan di kabupaten/kota. Pelayanan kesehatan adalah upaya yang diberikan oleh Puskesmas kepada masyarakat, mencakup perencanaan, pelaksanaan, evaluasi, pencatatan, pelaporan, dan dituangkan dalam suatu sistem. Pada penelitian ini, akan digunakan data persentase bayi yang diimunisasi yang merupakan salah satu layanan dari Puskesmas. Pelayanan imunisasi ini merupakan pelayanan imunisasi dasar meliputi BCG, DPT/HB1-3, polio 1-4 dan campak. Data persentase bayi yang diimunisasi belum memiliki pengelompokan sehingga pada penelitian ini akan diterapkan metode clustering untuk melakukan pengelompokan Puskesmas berdasarkan persentase bayi yang diimunisasi. Data persentase bayi dari masing-masing Puskesmas dijadikan data uji yang akan diterapkan pada proses multi-clustering dengan metode boost-clustering. Output dari penerapan metode ini akan dibandingkan dengan output metode clustering dasar k-means, hasil clustering akan diukur menggunakan metode silhouette index. Evaluasi menggunakan metode silhouette index dilakukan pada dataset puskesmas. Analisis dilakukan dengan melihat hasil evauasi dataset yang sudah diimplementasikan kedalam algoritma cluster dasar k-means dan algoritma multiclustering boost-k-means. Berdasarkan hasil evaluasi, diperoleh nilai silhouette index 0,798102756 untuk k-means dan 0,789901932 untuk boost-k-means, dengan ini algoritma yang diusulkan memiliki kualitas hasil clustering minimal sama atau lebih baik dari single clustering k-means dengan jumlah iterasi yang lebih sedikit
Empresas militares e de segurança privada nos mares: novos posicionamentos sobre os serviços de proteção armada contra a pirataria
Authors: Patriarca Gabriel , Lopes Cleber Da Silva
Published: November 2020

Refletindo uma responsabilidade estatal pela segurança marítima estabelecida há pelo menos um século e meio, posicionamentos contrários à proteção armada de embarcações civis foram sustentados por diversos stakeholders do transporte marítimo. Contudo, nas duas últimas décadas, o ressurgimento da pirataria e do roubo armado contra navios promoveu a prestação de serviços de proteção armada por empresas militares e de segurança privada (EMSPs), primeiro no Sudeste Asiático e depois no Chifre da África. No segundo caso, o fenômeno provocou mudanças nos posicionamentos anteriormente contrários à prática, notados pela literatura especializada de maneira fragmentada e genérica. Este artigo revisa essa literatura com o objetivo de explorar o modo como novos posicionamentos foram estabelecidos diante do maior protagonismo assumido pelas EMSPs, analisando as condições e a direção dessas mudanças. O trabalho identifica um ponto de inflexão nos posicionamentos de algumas das principais associações da indústria de transporte marítimo, do maior mercado de seguros marítimos, da Organização Marítima Internacional e dos Estados de bandeira e costeiros.