bluuebunny/crossref_metadata_2025 huggingface dataset:
A new method for preventing sidewall preferential flow in the internal erosion simulation using un-resolved CFD–DEM
Authors: Liu Leilei , Chen Rui , Li Zhaofeng , Zhou Chao , Li Xiaojiao
Published: January 2024

Accurately assessing the erodibility of geomaterials is of great significance for the design of earthen structures and the prevention of the associated failure induced by seepage force. Recently, the un-resolved Computational Fluid Dynamics–Discrete Element Method (CFD–DEM) has been widely used to investigate internal erosion. However, due to the use of wall boundary and the fact that the fixed CFD domain cannot be changed with the soil sample’s volume contraction during the erosion test, a larger porosity at the boundary of the CFD domain is commonly formed, resulting in sidewall preferential flow (i.e., relatively more fine particles migrate along the boundary of the DEM domain) and thereby overestimating the soil erodibility. In this study, a new method based on particle boundary is developed to tackle this problem. The newly proposed particle boundary can prevent its particles from erosion via inter-particle bonding and transfer stress from servo walls to the simulated sample. An optimal particle boundary thickness is determined by considering sample contraction and computational efficiency. The performance of the new method was compared with the conventional method and also verified using experimental results. The results show that the newly proposed method has significantly improved the uniformity of fluid velocity distribution. Furthermore, the cumulative eroded mass of fine particles in the new model is approximately 15% lower than in the conventional model. It is convincingly demonstrated that the new method can simulate internal erosion better and give a more accurate assessment of geomaterial erodibility.
Community-centred scenarios development for water–energy–food security on Zanzibar
Authors: Newman Rebecca J. S. , Capitani Claudia , Haji Tahir , Nchimbi Aziza , Enns Charis , Marchant Robert A.
Published: January 2024

Small developing islands demonstrate strong social–ecological interactions as well as a high level of exposure to climate-related effects, which can result in intense land use pressures. Scenario methodologies are useful for reflecting on how competing pressures interact when planning for a more sustainable future. In small islands, local knowledge is integral to the development of scenarios because of the close connection between people and local environments. However, local communities are often underrepresented in scenario development processes. This study provides a methodological example of how local knowledge can be used to create scenario themes. Ten community participatory workshops were hosted on Zanzibar (n = 142), where a water–energy–food framework was used to examine impacts of environmental change on resource security. Major drivers of land use and land cover change affecting water–energy–food security were identified; these include population growth, development and climate change. Solutions to observed challenges formed three coherent scenario themes, centred on adaptation, ecosystem health and sustainable settlements. Findings support the idea that communities need space to frame their resource challenges for sustainability planning to work at the appropriate scale.
Action research for transformative change
Authors: Croeser Thami , Clement Sarah , Fernandez Marta , Garrard Georgia E. , Mell Ian , Bekessy Sarah A.
Published: January 2024

As major policy actors (e.g. governments, global organisations) grapple with 'wicked’ sustainability challenges, the use of demonstration projects or ‘living labs’ has promise in showcasing potential solutions. However, these projects can struggle to realise enduring change, with initial experimental deliverables tending not to be replicated and remaining as once-offs. As well as demonstrating solutions, projects also need to overcome the considerable inertia in the complex systems of organisations and institutions that govern (or indeed generate) sustainability problems. Here we argue that demonstration projects, while initially impactful, could be more likely to realise transformative change if they were designed more thoroughly as action research projects, working with partners to not only deliver and measure demonstrations of solutions, but also demonstrate changes to organisations and institutions to remove barriers and facilitate replication. We note the important role of both engaged leadership and explicitly-stated theories of change in maximising the potential of projects designed in this way.
Titanium carbide MXene/silver nanostars composite as SERS substrate for thiram pesticide detection
Authors: Yusoff Nur Nazhifah , Nor Azmi Farah Shahadah , Abu Bakar Norhayati , Tengku Abdul Aziz Tengku Hasnan , Shapter Joseph George
Published: January 2024

Two-dimensional transition metal carbonitrides, Ti3C2Tx MXene nanosheets, have drawn much attention due to their unique optical properties. These materials have huge potential to be employed as surface-enhanced Raman scattering (SERS) substrates. Herein, to combine the benefits of metal nanoparticles and MXene as SERS substrates, we prepared composite SERS films with different volume ratios composed of Ti3C2Tx MXene with silver nanostars (AgNs) as a promising SERS substrate for detection of pesticides. These SERS films were prepared via a drop-casting technique. The SERS activities of the MXene/AgNs composites were evaluated through detection of the thiram pesticide. MXene/AgNs exhibited the highest SERS intensity compared to MXene or AgNs substrate alone. Sampling from 20 different areas and samples of the substrate gave very consistent SERS signals. The MXene/AgNs substrate shows good stability for 1 month when stored in a small transparent container with silica gel. The MXene/AgNs SERS substrate exhibits excellent sensitivity able to detect thiram concentrations as low as 10−8 M which also having low a relative standard deviation (RSD) value for reproducibility and stability over a significant period.
Nutritional Aspects to Cardiovascular Diseases and Type 2 Diabetes Mellitus
Authors: Billingsley Hayley E. , Heiston Emily M. , Bellissimo Moriah P. , Lavie Carl J. , Carbone Salvatore
Published: January 2024

Purpose of Review

In this narrative review, we discuss the current evidence related to the role of dietary interventions to prevent and treat type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). We also propose alternative therapeutic strategies other than weight loss in this population, namely, improvements in cardiorespiratory fitness and its determinants.

Recent Findings

While weight loss has been consistently associated with the prevention of T2DM and improvements in glycemic control in those with established diseases, its role in preventing and treating CVD is less clear. In fact, in this setting, improvements in diet quality have provided greater benefits, suggesting that this might represent an alternative, or an even more effective strategy than energy-restriction.

Improvements in diet quality, with and without caloric restriction have been shown to improve CVD risk and to prevent the development of T2DM in individuals at risk; however, with regard to glycemic control in patients with T2DM, any dietary intervention resulting in significant weight loss may produce clinically meaningful benefits. Finally, dietary interventions with and without energy restriction that can improve cardiorespiratory fitness, even in absence of weight loss in patients with obesity, should be encouraged.
Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment
Authors: Niemeyer Christy S. , Harlander-Locke Michael , Bubak Andrew N. , Rzasa-Lynn Rachael , Birlea Marius
Published: January 2024

Purpose of Review

Trigeminal postherpetic neuralgia (TG-PHN) is a neuropathic pain condition complicating herpes zoster (HZ) attributed to the trigeminal nerve. It poses significant challenges due to its persistent and debilitating nature. This review explores the clinical characteristics of TG-PHN, analyzes its pathophysiological underpinnings, and addresses existent and potential therapies.

Recent Findings

TG-PHN is one of the most common and complex PHN locations. It has distinguishing clinical and pathophysiological characteristics, starting with viral triggered injuries to the trigeminal ganglion (TG) and peripheral tissue and involving the ascending and descending brain modulation pathways. Current therapies include vaccines, oral and topical medications, and interventional approaches, like nerve blocks and neurostimulation.

This review covers TG-PHN’s clinical and physiological components, treatment options, and potential future targets for improved management. By exploring the complexities of this condition, we aim to contribute to developing more effective and targeted therapies for patients suffering from trigeminal PHN.
Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice
Authors: Nchodu Makgotso , Efuntayo Alice , du Preez Robin , Ali Hasiena , Olateju Oladiran I.
Published: January 2024

Alcohol abuse by adolescents is becoming a serious health concern as they often progress to becoming alcoholics later in life which may lead to heart problems. Chronic alcohol use alters the cardiac function and structure, such as haemodynamic changes, weakening and loss of cardiomyocytes, myocardial fibrosis, and inflammation. Simvastatin is a commonly used drug for the treatment and management of various cardiovascular problems but information on its protective effects against alcohol-induced cardiomyocyte hypertrophy, fibrosis, and inflammation is lacking in the literature. Four-week-old male (n = 5) and female (n = 5) C57BL/6 J mice were assigned to each experimental group: (I) NT—no administration of alcohol or Simvastatin; (II) ALC—2.5 g/Kg/day of 20% alcohol via intraperitoneal injection (i.p.); (III) SIM—5 mg/Kg/day of Simvastatin via oral gavage; (iv) ALC + SIM5—5 mg/Kg/day of Simvastatin via oral gavage followed by 2.5 g/Kg/day of 20% alcohol via i.p.; and (v) ALC + SIM15—15 mg/Kg/day Simvastatin via oral gavage followed by 2.5 g/Kg/day of 20% alcohol via i.p. After the 28-day treatment period, the heart was removed and processed for H&E, Masson’s trichrome, or TNF-α immunolabelling. The area and diameter of cardiomyocytes were measured on the H&E-stained sections. The distribution of collagen or TNF-α expression was quantified using the deconvolution tool of ImageJ software. The results confirmed alcohol-induced toxicity on the cardiomyocytes and Simvastatin reduced alcohol-induced cardiomyocyte hypertrophy, fibrosis, and inflammation in both sexes. This study demonstrated that Simvastatin, an FDA approved and easily accessible drug, may be beneficial in lowering the prevalence of alcohol-induced cardiovascular diseases (especially in adolescents) which will have a huge financial implication on health systems worldwide.
Bilateral Choanal Atresia in a 42-year-old Patient: A Rare Condition Case Report
Authors: Vieira Sávio Luquetti Silva , de Fátima Amiti Fabri Cecy , Lima Gabriela Cardoso , de Oliveira Tinoco Marina Bandoli , Padín-Iruegas Maria Elena , Tinoco Paulo , e Silva França Vieira
Published: January 2024

Choanal atresia is an uncommon condition with an incidence of 1:5,000–8,000 live births, affecting females more frequently and often associated with other malformations. This case report presents a 42-year-old female patient who was born with bilateral choanal atresia and intervened surgically for the first time at birth. However, the formed orifice was reobstructed a few months afterward, necessitating reoperation in adulthood. The purpose of this case report is to describe bilateral choanal atresia in detail, including its clinical presentation, epidemiology, diagnosis, pathogenesis, and therapeutic approach. It aims to enhance understanding of this rare but significant condition.
Progress in Understanding Consciousness? Easy and Hard Problems, and Philosophical and Empirical Perspectives
Authors: Wagner-Altendorf Tobias A.
Published: January 2024

David Chalmers has distinguished the “hard” and the “easy” problem of consciousness, arguing that progress on the “easy problem”—on pinpointing the physical/neural correlates of consciousness—will not necessarily involve progress on the hard problem—on explaining why consciousness, in the first place, emerges from physical processing. Chalmers, however, was hopeful that refined theorizing would eventually yield philosophical progress. In particular, he argued that panpsychism might be a candidate account to solve the hard problem. Here, I provide a concise stock-take on both the empirical-neuroscientific and philosophical-conceptual progress on consciousness. It turns out that, whereas empirical progress is indisputable, philosophical progress is much less pronounced. While Chalmers was right, I argue, in distinguishing distinctive types of problems of consciousness, his prediction of progress on the hard problem was overly optimistic. Empirical progress and philosophical progress are essentially uncoupled; a more skeptical perspective on progress in philosophy in general is appropriate.
The right side of price: evidence of a SNARC-like effect for economic value
Authors: Giuliani Felice , Brunello Loris , Dalmaso Mario , D’Anselmo Anita , Tommasi Luca , Vicovaro Michele
Published: January 2024

It is well known that both numerical and non-numerical magnitudes can be represented horizontally from left to right. Building on this knowledge, here we explored whether a similar spatial representation exists for the economic value of goods. Participants were presented with images of a reference and a target product and classified the economic value of the target as higher or lower than that of the reference (Experiments 1 and 2), or classified the target product as belonging to the same or different semantic category as the reference (Experiment 3). Responses were collected using lateralized keys. Evidence of a SNARC-like effect for economic value emerged, whereby low economic value was associated with the left side of space, and high economic value was associated with the right side of space. Importantly, this spatial representation appeared to be based on external spatial coordinates and only emerged when the economic value was treated as an explicit dimension. Regression analyses also ruled out the potential contributions of other dimensions, such as the presumed physical weight of the target products or their valence. These findings support the hypothesis of a general magnitude representation system.
Meta-analytic factor analysis of the UCLA loneliness scale
Authors: Ozdemir Vildan , Tan Seref
Published: January 2024

The UCLA (University of California, Los Angeles) Loneliness Scale is frequently employed instrument for assessing the structure of loneliness in psychology studies. Although many studies have tested the scale’s factor structure, the literature has produced inconsistent findings or different results. Some studies support a unidimensional structure, while other studies support a multidimensional structure including two-factor, three-factor, five-factor models. Moreover, these dimensions are denoted differently across studies. Hence, this study employs meta-analytical structural equation modeling (MASEM) to investigate the factor structure of the UCLA Loneliness Scale, MASEM provides more precise parameter estimations than conventional structural equation modeling and allows for the synthesis of conflicting findings concerning factor structure. Furthermore, MASEM provides an examination of the factor structure by utilizing correlation matrices from studies in which the scale has been employed but without a specific examination of its factor structures. Consequently, this study analyzed the correlation matrices from 52 studies encompassing 52 correlation matrices. The results of the meta-analysis revealed that the two-factor and second-order three-factor models provided the best fit for the pooled correlation matrix. Even when considering subgroup analyses based on sample size and sample age, which are possible variables that can explain heterogeneity, the three-factor structure of the scale remained consistent. This suggests that different variables may account for the observed heterogeneity.
The ‘Mascara Boys’: Performance, Subversion, and the New Pakistani Masculinity
Authors: Salam-Salmaoui Rauha , Salam Shazrah
Published: January 2024

This study offers an exploration into the performative expressions of gender and masculinity by the "Mascara Boys" in Pakistan. Situating the research within the frameworks of performativity theory and hybrid masculinities, the study investigates how these individuals subvert and challenge established masculinity norms through the strategic use of Instagram as a transgressive digital space. The findings reveal a multifaceted landscape where digital platforms act as both a stage and a catalyst for conversations on gender diversity, both within Pakistan and transnationally. The Mascara Boys emerge as agents of change who navigate complex intersections of socio-cultural expectations to embody a form of hybrid masculinity that is both locally informed and globally resonant. Through their intentional acts, they not only disturb entrenched heteropatriarchal structures but also contribute to a richer, more complex understanding of masculinity. The study concludes that their emergence as practitioners of hybrid masculinity within the Pakistani context signals a significant paradigm shift, urging a re-evaluation of normative gender roles and paving the way for a more inclusive discourse on gender diversity in Pakistan.
Leverage and SMEs financial stability: the role of banking competition
Authors: Agostino Mariarosaria , Errico Lucia , Rondinella Sandro , Trivieri Francesco
Published: January 2024

This work exploits a large panel dataset on Italian manufacturing SMEs to examine the relationship between leverage and firms’ financial stability. Specifically, we evaluate whether and to what extent this link is affected by the degree of competition characterising the local credit market in which firms operate. Using two measures of local banking competition – the H-statistic and the Boone indicator – our evidence indicates that the negative impact of leverage on firms’ financial health is greater for firms operating in more competitive banking markets. A plausible interpretation of this finding is that the competition drawbacks could prevail on its expected advantages, leading banks to be less inclined to establish lending relationships with risky firms, thus exacerbating their financial vulnerability.
Cutaneous Infections by Geotrichum spp.
Authors: Román-Montes Carla M. , Sifuentes-Osornio José , Martínez-Gamboa Areli
Published: January 2024

Purpose of Review

We present the risk factors, clinical presentation, and current recommendations for diagnosing and treating cutaneous infections due to Geotrichum spp.

Recent Findings

Skin infections caused by Geotrichum spp. are infrequent. G. candidum and G. klebahnii are the only species of the genus responsible for human infections. In immunocompetent patients, these infections occur due to severe trauma or burns, while in immunosuppressed patients, they are mainly a consequence of dissemination.

Geotrichum spp. infection is challenging to discriminate with colonization because it is a ubiquitous skin colonizer, in such a way that clinical suspicion is essential to achieve the diagnosis. There are no breakpoints or epidemiological cut-off values to interpret antifungal susceptibility tests. Amphotericin B and voriconazole have been the most widely used antifungals in treatment. Active surveillance studies are required to understand these infections’ characteristics and real burden.
Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma
Authors: Zazara Dimitra E. , Giannou Olympia , Schepanski Steven , Pagenkemper Mirja , Giannou Anastasios D. , Pincus Maike , Belios Ioannis , Bonn Stefan , Muntau Ania C. , Hecher Kurt , Diemert Anke , Arck Petra Clara
Published: January 2024

Background

Early-life respiratory infections and asthma are major health burdens during childhood. Markers predicting an increased risk for early-life respiratory diseases are sparse. Here, we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and asthma.

Methods

Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy cohort. Correlations between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were examined. Machine-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung growth. For model development and validation, study participants were randomly divided into a training and a testing group, respectively, by the employed algorithm.

Results

Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection risk. Male sex was associated with a higher risk for respiratory infections in infancy. Fetal lung growth could also predict the risk of asthma at five years of age. We designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset asthma. The models’ R2 values were 0.92, 0.90 and 0.93, respectively, underscoring a high accuracy and agreement between the actual and predicted values. Influential variables included known risk factors and novel predictors, such as ultrasound-monitored fetal lung growth.

Conclusion

Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

Graphical abstract
Consumers’ ambiguous perceptions of advertising disclosures in influencer marketing: Disentangling the effects on current and future social media engagement
Authors: Waltenrath Adrian
Published: January 2024

Based on a large real-world dataset comprising Instagram posts of popular influencers, this study empirically analyzes the impact of disclosed and undisclosed advertising on consumers’ engagement with (a) the advertisement and (b) future non-advertising posts of the same author. As extant research reports inconsistent effects of ad disclosures based on inferred motives, persuasion knowledge, and source credibility, this study develops a conceptual framework incorporating these theoretical concepts. To identify undisclosed advertisements, we use data from regions with proper disclosure culture to train a model to predict if posts are advertising. Based on the predictions for > 65,000 posts of 239 macro-influencers, we find that advertising posts gather less engagement than non-advertising posts. Regarding immediate ad engagement, we find that disclosed ads gather less engagement than undisclosed ads. Contrastingly, when analyzing future engagement, we identify positive persistent effects of disclosed advertising and negative persistent effects of undisclosed advertising on consumers’ engagement with future posts of the same author. We conclude that source credibility explains the effect of disclosures on future posts, while the Persuasion Knowledge Model can explain the effect of disclosures on the current advertisement. Thus, consumers’ coping strategies triggered by activated persuasion knowledge are mostly limited to the advertisement. Our findings can explain the opposing results of extant research. From a managerial perspective, we find that by not disclosing advertising posts, influencers and marketers increase an ad’s engagement levels at the expense of persistently lowered attitudes. Conversely, in the long run, they may benefit from transparent disclosures.
Nature of Oxides in Al–Mg Alloys
Authors: Niu Zhichao , Wang Shihao , Gao Feng , Fan Zhongyun
Published: January 2024

Acting as substrates for heterogeneous nucleation, native oxides in Al–Mg alloys have shown their potential for grain refinement. However, the limited knowledge about the nature of the oxides in Al–Mg alloys impedes the widespread application as native grain refiners. The aim of this work is to comprehensively investigate the native oxides in Al–Mg alloys through electron microscopy. Our results show that the predominant inclusions in Al–Mg alloys are oxides in three types of oxide films at the micrometer scales: young films, old films and oxide skins. All oxide films consist of discrete oxide particles of three types in nanometer scale depending on the Mg contents: γAl2O3 (< 0.4 wt.%), MgAl2O4 (0.08–3.5 wt.%) and MgO (> 2 wt.%). Specifically, MgAl2O4 particles have sizes ranging from a few tens to a few hundreds nanometer and possess an elementary shape of octahedron faceted by {111} planes. In Al–Mg alloys, the native oxides have a lognormal size distribution, with the average mean size fluctuating in accordance with the oxide configurations as Mg content varies. The agglomerating feature causes inhomogeneous sampling, and dual-peak lognormal curves are found for low-Mg-content alloys (0.08/0.4%), which could be eliminated by increasing the Mg content (2.0/3.5%) or by using the high-shear melt conditioning (HSMC) technology. Understanding the native oxides in Al–Mg alloys shall provide instructions on their application in grain refinement.
Classical symmetries of the Klein–Gordon–Zakharov equations with time-dependent variable coefficients
Authors: Devi Preeti , Guleria Abhishek
Published: January 2024

In this article, we employ the group-theoretic methods to explore the Lie symmetries of the Klein–Gordon–Zakharov equations, which include time-dependent coefficients. We obtain the Lie point symmetries admitted by the Klein–Gordon–Zakharov equations along with the forms of variable coefficients. From the resulting symmetries, we construct similarity reductions.The similarity reductions are further analyzed using the power series method/approach and furnished the series solutions. Additionally, the convergence of the series solutions has been reported.
Do Exercise-Based Prevention Programs Reduce Injury in Endurance Runners? A Systematic Review and Meta-Analysis
Authors: Wu Han , Brooke-Wavell Katherine , Fong Daniel T. P. , Paquette Max R. , Blagrove Richard C.
Published: January 2024

Background

Endurance running is a popular sport and recreational activity yet is associated with a high prevalence of injury. Running related injuries (RRIs) are a leading cause of drop-out and represent a substantial financial burden to runners and healthcare services. There is clear evidence for the use of exercise-based injury prevention programs in games-based and youth sport settings, yet the research investigating the use of exercise to reduce injury risk in endurance runners has not been adequately reviewed recently.

Objectives

The aim of this review and meta-analysis was to systematically summarize the current research that has investigated the effect of exercise-based prevention programs and their state of supervision on the risk of RRIs in endurance runners.

Methods

Three databases were searched for relevant studies. Selection and review were completed by two independent reviewers using the following inclusion criteria: (1) study population used endurance running training for health, occupational, or performance outcome(s); (2) participants performed running as their main form of exercise (> 50% of their total training time); (3) study was a randomized controlled trial; (4) a non-running-based exercise intervention was used; (5) a running-only or placebo exercise control group was included; (6) injury rate or incidence was reported; (7) injuries were recorded prospectively alongside the exercise training. Two meta-analyses were conducted using random-effects models, one based on log risk ratio and one based on log incidence rate ratio. The Cochrane Risk of Bias Assessment Tool 2 was used to evaluate the quality of studies and the Grading of Recommendations Assessment, Development and Evaluations approach was employed to grade the certainty of evidence.

Results

A total of nine articles containing 1904 participants were included in analysis. Overall pooled results showed no significant differences between intervention and control groups in injury risk (z = − 1.60; p = 0.110) and injury rate (z = − 0.98; p = 0.329), while a post hoc analysis evaluating supervised interventions only showed that injury risk was significantly lower in the intervention group compared to the control group (z = − 3.75, p < 0.001). Risk of bias assessment revealed that seven studies included in the analysis were of low quality.

Conclusions

Exercise-based interventions do not appear to reduce the risk and rate of running-related injuries. Supervision may be essential for exercise-based intervention programs to reduce risk of RRIs, possibly due to increased compliance. Studies with more robust designs that include supervised exercise interventions should be prioritized in the future.

Trial Registry

Clinical Trial Registration: PROSPERO CRD42021211274.
Breaking the Law of Inertia for Students with Poor Grit and Achievement: The Predictive Mechanism of Grit on the Short-Term and Long-Term Achievement
Authors: Weng Min-Chieh , Liao Chen-Hsuan , Kwok Oi-Man , Wu Jiun-Yu
Published: January 2024

This study aimed to examine the predictive validity of junior high students’ grit (including perseverance of effort (PE) and consistency of interest (CI)) on their short-term and long-term academic achievements using a longitudinal survey design under the structural equation modeling framework. Data were collected on 236 junior high students (56.3% boys) in Taiwan across three years. The analytical results showed that PE successively influences students’ semester grades (as short-term achievements) in a unidirectional way. However, CI could not predict the consecutive semester grades. Furthermore, we found that both PE and CI did not directly predict students’ achievement on the scores of the Comprehensive Assessment Program (CAP, as long-term achievements). Only PE can indirectly associate with the CAP scores via students’ successive semester grades. The study results can be explained by the goal hierarchy of grit, where achieving good semester grades can be treated as the lower-order goals that are cohesively aligned with the superordinate goal to do well in the CAP. Strategies for fostering students’ perseverance of effort and implications for future research on educational equity are discussed.
Is there a role for [18F]-FMISO PET to guide dose adaptive radiotherapy in head and neck cancer? A review of the literature
Authors: Sambasivan Khrishanthne , Barrington Sally F. , Connor Steve E. J. , Witney Timothy H. , Blower Philip J. , Urbano Teresa Guerrero
Published: January 2024

Purpose

Hypoxia is a major cause of radioresistance in head and neck cancer (HNC), resulting in treatment failure and disease recurrence. 18F-fluoromisonidazole ([18F]FMISO) PET has been proposed as a means of localising intratumoural hypoxia in HNC so that radiotherapy can be specifically escalated in hypoxic regions. This concept may be challenging to implement in routine clinical practice however, given that [18F]FMISO PET is costly, time consuming and difficult to access. The aim of this review was to summarise clinical studies involving [18F]FMISO PET and to appraise the evidence for its role in guiding radiotherapy treatment in HNC.

Methods

A comprehensive literature search was conducted on PubMed and Web of Science databases. Studies investigating [18F]FMISO PET in newly diagnosed HNC patients were considered eligible for review.

Results

We found the following important results from our literature review: (1) Studies have demonstrated a correlation between [18F]FMISO PET and other hypoxia biomarkers, although the results are not consistent enough to propose a proxy biomarker of [18F]FMISO PET. (2) [18F]FMISO PET uptake changes during a course of radiotherapy treatment, suggesting that imaging should be repeated during treatment. (3) Tumour recurrences do not always occur within the pretreatment hypoxic volume on [18F]FMISO PET. (4) Dose modification studies using [18F]FMISO PET are in a pilot phase.

Conclusions

Our results show that currently there is insufficient evidence to propose [18F]FMISO PET for radiotherapy dose adaptation in HNC in a routine clinical setting. Part of the challenge is that hypoxia is a dynamic phenomenon, and thus areas identified on a single scan may not be representative. At present, it is anticipated that [18F]FMISO PET will remain useful within the research setting only.
Undernutrition in obese older adults by fat percentage
Authors: Bozkurt Meris Esra , Erdogan Tugba , Catikkas Nezahat Muge , Ozkok Serdar , Kilic Cihan , Bahat Gulistan , Karan Mehmet Akif
Published: January 2024

Objective

The prevalence of obesity by fat percentage has seen a steady increase in older adults in recent years, secondary to increases in fat mass in body composition, even in healthy aging. Malnutrition is a common geriatric syndrome with serious clinical outcomes. Increases in fat mass and waist circumference with healthy aging should not prevent the risk of malnutrition from being masked. Malnutrition is often ignored in obese older people due to low BMI cut-off values in many screening tests. The present study seeks to raise awareness of the need to assess the frequency of undernutrition and related factors in obese older adults.

Methods

The data of 2013 community-dwelling patients aged ≥ 60 years who applied to a university geriatrics outpatient clinic between April 2012 and November 2022 were analyzed retrospectively, of which 296 were found to be obese based on fat percentage and were included in the study. Demographic data and the presence of any geriatric syndromes were obtained retrospectively from the patient files, functional status was assessed using the KATZ Activities of Daily Living (ADL) Scale and the LAWTON-BRODY Instrumental Activities of Daily Living Scale (IADL); frailty was screened using FRAIL-scale; and the sample was assessed for malnutrition using the Mini Nutritional Assessment-Short Form (MNA-SF), with undernutrition defined as an MNA-SF score of $$\le 11.$$

≤
11
.

The patients’ fat percentage and weight were measured using a bioimpedance analyzer. Fatty obesity was defined using the Zoico methodology (fat percentage $$\ge$$
≥
27.3% for males, $$\ge$$
≥
40.7% for females)$$,$$
,
handgrip strength (HGS) was measured using a hand dynamometer, and probable sarcopenia was defined as low HGS based on regional cut-off values (35 kg for males, 20 kg for females).

Results

The mean age of the 296 fatty obese older adults (102 males/194 females) was 74.4 + 6.5 years, and the median fat was 42.2% (27.4–59.5). Undernutrition was detected in 19.6% of the patients based on MNA-SF screening. A univariate analysis revealed age, sex, educational status, daily physical activity status, depression, difficulty in swallowing, chewing difficulty, probable sarcopenia, number of chronic diseases, and IADL to be associated with undernutrition, while a multivariate logistic regression analysis revealed depression [OR = 3.662, 95% CI (1.448–9.013), p = 0.005] and daily physical activity status [OR:0.601, 95% CI (0.417–0.867), p = 0.006] to be independently associated with malnutrition in obese older adults based on fat percentage.

Conclusion

 The present study clarifies the significance of undernutrition in obese older adults also in our country, and recommends undernutrition screening to be carried out, by fat percentage, on obese older adults, especially with depression and low daily physical activity.
Improving Sleep to Improve Stress Resilience
Authors: Lo Martire Viviana , Berteotti Chiara , Zoccoli Giovanna , Bastianini Stefano
Published: January 2024

Purpose of Review

The neuroendocrine stress response is a natural process of our body which, however, might become toxic if not properly turned on and off. Resilience is the ability to adapt to adverse situations and, particularly, to cope with uncontrolled stress. Resilience and stress are two opposite faces of the same coin, and both are deeply linked to sleep: low resilience means higher stress and, through that, more sleep disorders. The aim of the present paper is to review the complex relationship between these actors and to highlight the possible positive role of good sleep in contrasting chronic stress situations.

Recent Findings

Promotion of cognitive-behavioral therapy for insomnia patients improves sleep quality and, through that, produces lower general stress, lower depressive symptom severity, and better global health.

Sleep is a modifiable behavior and, according to recent studies, its improvement might enhance resilience and, in turn, reduce stress.
Evaluate the current and predict the future real GDP of Afar regional state, Ethiopia
Authors: Ali Abdurhman Kedir , Abdulkadr Ahmed Abduletif , Habtie Getnet Mamo , Asfaw Dagmawe Menelek
Published: January 2024

Ethiopia has implemented numerous national development plans and strategies to achieve sustainable economic growth at both the national and regional levels, specifically in the Afar region. However, there has been a lack of assessment regarding the outcomes and expected goals of these plans and strategies, particularly for the regional economy. Hence, this study assesses the current and future gross domestic product (GDP) of Ethiopia’s Afar regional state. It analyzes the data using a descriptive and econometric model called autoregressive integrated moving average (ARIMA). The analysis shows that the regional GDP has been increasing over time, but per capita income remains below the national average. The service sector dominates the economy, while the growth of the industry sector has been stagnant. This indicates that development policies have not achieved their goals of reducing poverty and transforming the economy. Using the ARIMA model, it is projected that the Afar regional GDP will gradually increase from 19,300.20 Billion Birr to 21,678.20 Billion Birr between 2023q1 and 2025q4, with an average growth rate of 10%. It is important for development policies to prioritize not just economic growth, but also social development within local communities. This involves addressing issues related to institutional capacity, and governance, and leveraging agricultural resources to benefit agro-pastoralists and pastoralists, as the agricultural sector is the main driver of the economy. By understanding the present and projected GDP of the Afar regional state, policymakers and stakeholders can make informed decisions for sustainable and inclusive economic growth.
A Quasi-experimental Study on the Effect of Pre-entry Tuberculosis Screening for Immigrants on Treatment Outcomes in South Korea: A Difference-in-Differences Analysis
Authors: Yu Sarah , Jeong Dawoon , Kang Hee-Yeon , Kang Young Ae , Lee Gyeong In , Choi Hongjo
Published: January 2024

Objective

This study ascertains the effects of the pre-entry tuberculosis (TB) screening policy, which was implemented as a strategy for managing TB among immigrants, on the treatment outcomes of immigrants in South Korea.

Methods

This study linked three different datasets from 2013 to 2018, namely (1) Korean National Tuberculosis Surveillance System; (2) National Health Information Database for patients diagnosed with TB with ICD code A15-A19, B90, or U84.3; and (3) Statistics Korea database related to cause of deaths. To identify the effect of the policy, cohorts comprising Korean and immigrant TB patients notified before (January 1, 2013–December 31, 2015) and after (September 1, 2016–December 31, 2018), the implementations of the policy were established. A difference-in-differences (DID) analysis of the treatment success and mortality rates was performed.

Results

Data from 100,262 TB patients were included in the analysis (before policy implementation: 1240 immigrants and 65,723 Koreans; after policy implementation: 256 immigrants and 33,043 Koreans). The propensity score matching-DID analysis results showed that the difference in the treatment success rate between immigrants and Koreans decreased significantly, from 16% before to 6% after the policy implementation. The difference in the mortality rate between the two groups decreased from − 3% before to − 1% after the policy implementation; however, this difference was insignificant.

Conclusion

The treatment outcomes of immigrant TB patients in South Korea improved after the implementation of the pre-entry active TB screening policy. Future immigrant TB policies should consider establishing active patient support strategies and a healthcare collaboration system between countries.
The least singular value of a random symmetric matrix
Authors: Campos Marcelo , Jenssen Matthew , Michelen Marcus , Sahasrabudhe Julian
Published: January 2024

Let A be an

$n \times n$

symmetric matrix with

$(A_{i,j})_{i\leqslant j}$

independent and identically distributed according to a subgaussian distribution. We show that

$$ \begin{align*}\mathbb{P}(\sigma_{\min}(A) \leqslant \varepsilon n^{-1/2} ) \leqslant C \varepsilon + e^{-cn},\end{align*} $$

where

$\sigma _{\min }(A)$

denotes the least singular value of A and the constants

$C,c>0 $

depend only on the distribution of the entries of A. This result confirms the folklore conjecture on the lower tail of the least singular value of such matrices and is best possible up to the dependence of the constants on the distribution of

$A_{i,j}$

. Along the way, we prove that the probability that A has a repeated eigenvalue is

$e^{-\Omega (n)}$

, thus confirming a conjecture of Nguyen, Tao and Vu [Probab. Theory Relat. Fields 167 (2017), 777–816].
Cavitation bubble dynamics inside a droplet suspended in a different host fluid
Authors: Li Shuai , Zhao Zhesheng , Zhang A-Man , Han Rui
Published: January 2024

In this paper, we present a theoretical, experimental and numerical study of the dynamics of cavitation bubbles inside a droplet suspended in another host fluid. On the theoretical side, we provided a modified Rayleigh collapse time and natural frequency for spherical bubbles in our particular context, characterized by the density ratio between the two liquids and the bubble-to-droplet size ratio. Regarding the experimental aspect, experiments were carried out for laser-induced cavitation bubbles inside oil-in-water (O/W) or water-in-oil (W/O) droplets. Two distinct fluid-mixing mechanisms were unveiled in the two systems, respectively. In the case of O/W droplets, a liquid jet emerges around the end of the bubble collapse phase, effectively penetrating the droplet interface. We offer a detailed analysis of the criteria governing jet penetration, involving the standoff parameter and impact velocity of the bubble jet on the droplet surface. Conversely, in the scenario involving W/O droplets, the bubble traverses the droplet interior, inducing global motion and eventually leading to droplet pinch-off when the local Weber number exceeds a critical value. This phenomenon is elucidated through the equilibrium between interfacial and kinetic energies. Lastly, our boundary integral model faithfully reproduces the essential physics of the non-spherical bubble dynamics observed in the experiments. We conduct a parametric study spanning a wide parameter space to investigate bubble–droplet interactions. The insights from this study could serve as a valuable reference for practical applications in the field of ultrasonic emulsification, pharmacy, etc.
Multi-periodicity in the high gravity blue large amplitude pulsator ZTF J071329.02-152125.2
Authors: Koen Chris
Published: January 2024

New time series photometry of the pulsating hot subdwarf star ZTF J071329.02-152125.2 is presented. Rapid (timescale of hours) changes in the amplitude of the known pulsation in the star was observed. This could be ascribed to beating between three closely spaced frequencies, but analysis of all available photometry finds a range of different frequencies, with widely different amplitudes. A new frequency of 49.66 d

$^{-1}$

, suggestive of gravity-mode pulsation, was also discovered. The star may be a hybrid p-mode/g-mode hot subdwarf pulsator which sometimes exhibits extraordinarily large amplitude variability.
“APPROXIMATE” WIGGLE-MATCH DATING APPLIED TO EARLY AMERICAN MUSEUM OBJECTS
Authors: Hadden Carla S , Napora Katharine G , Tharp Brent W
Published: January 2024

Wiggle-match dating of tree-ring sequences is particularly promising for achieving high-resolution dating across periods with reversals and plateaus in the calibration curve, such as the entire post-Columbian period of North American history. Here we describe a modified procedure for wiggle-match dating that facilitates precise dating of wooden museum objects while minimizing damage due to destructive sampling. We present two case studies, a dugout canoe and wooden trough, both expected to date to the 18th–19th century. (1) Tree rings were counted and sampled for dating from exposed, rough cross-sections in the wood, with no or minimal surface preparation, to preserve these fragile objects; (2) dating focused on the innermost and outermost portions of the sequences; and (3) due to the crude counting and sampling procedures, the wiggle-match was approximated using a simple ordered Sequence, with gaps defined as Intervals. In both cases, the outermost rings were dated with precision of 30 years or better, demonstrating the potential of wiggle-match dating for post-European Contact canoes and other similar objects.
The Evolution of Scottish Enlightenment Publishing
Authors: Ryan Yann Ciarán , Tolonen Mikko
Published: January 2024

This article uses large-scale bibliographic data to extract and analyse the works, authors, and publishers of the Scottish Enlightenment. By doing so, we aim to encompass a wider scope and definition of Scottish Enlightenment publishing, contextualizing both the major and the lesser-known publishers. We reveal two competing models for key Scottish publishers: those working in Scotland, publishing works that were printed later in London; and those working in London, printing Scottish works. We show that the careers of key publishers such as Andrew Millar (1705–68) should be considered in relational terms: that Millar must be understood in the context of his wider network, taking into account a longer view of the publishing landscape both before and after his career. Moreover, we establish the relevance of subsequent editions of existing works for the understanding of eighteenth-century publishing. The article also argues for an agnostic view of the ‘Scottish Enlightenment text’, one which considers the features of individual texts rather than a priori assumptions about canonical works. Consequently, we show that the significance of works of scientific improvement evolves and becomes intertwined with education, literature, philosophy, and history over time; resulting in a convergence of practice, theory, and literary expression.
The limits of criminal justice reform: an analysis of elite rhetoric in four cities
Authors: Tatz Erin , Bekele Helen , Mattioli Lauren , Piston Spencer
Published: January 2024

As the coronavirus pandemic swept the nation in 2020, many emphasized that carceral spaces were hotspots for the virus, leaving Black and Brown people especially vulnerable to infection. In combination with other critiques of racism in the carceral state, these observations created pressure to decarcerate, especially on the political left. How did political elites discuss the carceral state in this changed atmosphere? To answer this question, we analyze rhetoric in public statements across four liberal metropolitan areas during the spring and summer of 2020. In these statements, we find a long-standing discourse of racially paternalist penal welfarism, retrofitted to pandemic times and accompanied by a distinction between “deserving” and “undeserving” criminals. Accommodating portrayals of incarcerated people as vulnerable to COVID-19 and in desperate need of care, this pattern of rhetoric positioned the carceral state as a protector in order to justify continued incarceration.