bluuebunny/crossref_metadata_2025 huggingface dataset:
Athonite greek life of st. Anthony of Kiev
Authors: Bibikov Mikhail , Rodionov Oleg
Published: November 2022

The article introduces into scholarly circulation the Greek text of the handwritten Life of Anthony of the Caves, which has recently come to the attention of researchers and is preserved in the archives of Athos hardly available until recently. For the first time, a critical edition of the Greek text of the Life is being published, the translation of which was carried out recently and published in the 2018 Kapterevskie Chteniya paper collection. We consider six known copies of a newly discovered monument of Greek Athos literature – the approximately thousand-page “Athoniad” by Jacob Neasketiotes, through which the Life has come down to us. The appendix to the article contains the first critical edition of the Greek text of the Life. The article also discusses the obvious sources of the Greek text, from the Tale of Bygone Years and the Kiev Caves Patericon to the Greek hagiographic collections of the 18th and the 19th centuries. Another interesting question is the connection of the work of the Athonite monk, author and copyist Jacob Neasketiotes with Russian matter, which could be explained by his stay while working on the “Athoniad” in the Russian monastery of St. Panteleimon on Athos and communication with the confessor of the Rossikon Fr. Jerome (Solomentsov). This also explains the presence of several codices with the Lives of Theodosius of the Caves, Mitrofan of Voronezh, and other texts related to Russia in the collection of manuscripts of St. Panteleimon Monastery. The original versions of the “Athoniad”, apparently, strongly depended on the historiographical works of another famous Athonite erudite, Theodoretos Lauriotes, who was a relative of Jacob Neasketiotes.
New compound names in Lithuanian: diversity and formation peculiarities (the 2nd decade of the 21st century)
Authors: Sinkevičiūtė Daiva
Published: November 2022

In the 2nd decade of the 21st century the Lithuanian stock of proper names is enriched with new compound names. They are formed in the following ways: a) from ordinary compound names, either changing or adding a new termination or altering the stems, e.g. Jo-gaĩl-is beside Jo-gáil-a, Dei-mant-ė́ja beside Deĩ-mant-ė, Ei-výl-ė beside Ei-vìl-ė; b) adding to a new name a stem used in other compound names, e.g. Ner-mìl-ė, Man-gìr-is; c) from Lithuanian stems of different origin (appellatives, hypocoristics, borrowings) added to the stem of other compound names, e.g. Bang-ì-mant-as: bang- < bangà ‘wave’, Jó-vyt-ė: vyt- < Výta, Výtė, Výtautė, Teo-mìl-ė: teo- < Teo, Teodorà; d) combining two new expansive stems, e.g. Ad-vità ← ad- < Adà, Adèlė + -vita < Vità, Jovità, Oks-mind-à ← oks- < Oksanà + mind- < Mìnda, Mìndaugė. These names continue the tendencies of the formation of names of the previous period. Most names are made without taking semantics into consideration. The stems are taken from popular names. The first stems are more diverse than the second, which coincide with frequent stems from the previous century. New stems are more frequent as first members of the compound. They are more often made from borrowings than from inherited lexicon. Some of them became stable new stems, etc. All this shows that the creation of new compound names remains an ongoing process.
Glucose biosensors and glucose-powered biofuel cells
Authors:   , Žukauskas Šarūnas
Published: November 2022

Gliukozės biojutikliai ir gliukozės biokuro elementai
CAMBIOS EN LA DISTRIBUCIÓN DEL INGRESO FAMILIAR EN COSTA RICA DURANTE LA PRIMERA DÉCADA DEL SIGLO XXI
Authors: Trejos S. Juan Diego , Oviedo C. Luis Ángel
Published: November 2022

Costa Rica no sigue durante la primera década del siglo XXI la tendencia observada para la mayoría de los países de la región, que experimentan una reducción de la desigualdad en la distribución del ingreso familiar per cápita. Durante la primera mitad de esa década sí se produce una reducción en la desigualdad pero se revierte en el quinquenio siguiente. Para estudiar esos cambios se utiliza una desagregación de la desigualdad, medida por el coeficiente de Gini, por fuentes de ingreso, usando 12 fuentes distintas. Los resultados señalan que la reducción de la desigualdad en la primera mitad de la década, se da en un contexto de crecimiento económico pero estancamiento de los ingresos reales, que se concentra en los estratos de mayores ingresos. Esto implica que la reducción de la desigualdad se concentró en la reducción de los ingresos reales de las fuentes con mayor poder concentrador (elasticidades Gini ingreso mayor a la unidad y cambios marginales positivos), como lo son los ingresos laborales de los más calificados, las rentas del capital y las pensiones contributivas. En la segunda mitad de la década, el repunte de la desigualdad se produce por un aumento significativo de los ingresos reales de todas las fuentes, pero principalmente de las que tienen un impacto concentrador que no puede ser neutralizado por la expansión de las fuentes que reducen la desigualdad (ingresos laborales de los trabajadores no calificados y las transferencias estatales). Los resultados sugieren la necesidad de aplicar una política de salarios mínimos más activa, reforzar los programas de apoyo productivo para el sector informal, ampliar la oferta de trabajadores más calificados a través de la política educativa y ampliar las transferencias monetarias hacia los más pobres, lo que requiere de una reforma tributaria.
COMPETITIVIDAD DEL TRANSPORTE EN EL MARCO DEL COMERCIO INTERNACIONAL
Authors: Zamora Torres América I. , Pedraza Rendón Oscar H.
Published: November 2022

Actualmente casi todos los envíos internacionales necesitan usar más de un tipo de transporte, desde el punto de origen al destino final. Cada uno de los tipos de transporte mundiales de carga y pasajeros ha desempeñado un papel esencial para facilitar la diversificación geográfica. En este trabajo se evalúa a través del Análisis de Componentes Principales la competitividad del transporte internacional, considerando a su vez las variables más importantes que inciden en este sector y el desempeño de las economías respecto de dichas variables, y además se analiza la estructura del sistema de transporte internacional para veintinueve países entre ellos siete de América Latina. Los resultados mostrados en el índice de competitividad del transporte internacional señalan que los países más competitivos en materia de transporte internacional acorde a las variables analizadas son en orden descendente: Hong Kong, Estados Unidos, Singapur, China, Suecia, España, Japón, Bélgica, Dinamarca y Canadá. Cabe señalar que los países de América Latina con mayores puntuaciones en este rubro son Brasil, seguido de Panamá, Chile y Costa Rica.
GASTO TOTAL EN SALUD Y RESULTADOS
Authors: Lago Fernando Pablo , Geri Milva , Moscoso Nebel Silvana , Monterubbianes Pablo Daniel
Published: November 2022

El objetivo del presente trabajo consiste en analizar, para una muestra amplia de países, la relación entre el gasto total en salud, el ingreso nacional y el estatus de salud poblacional. Se realiza un estudio descriptivo, cuantitativo y ecológico con base en datos de 192 países provistos por la Organización Mundial de la Salud (OMS), para los años 2000 y 2009. Los indicadores utilizados para medir el estatus de salud son la Esperanza de Vida al Nacer (EVN) y la Tasa de Mortalidad Infantil (TMI). Si bien este estudio no permite hacer conclusiones respecto a la existencia de causalidad, el análisis estadístico realizado permite afirmar que existe una relación positiva y estable entre los resultados en salud, el gasto en salud per cápita y el ingreso nacional per cápita.
ANÁLISIS DE LA DINÁMICA REGIONAL DEL EMPLEO UTILIZANDO EL MODELO SHIFT SHARE ESPACIALMENTE MODIFICADO EN LA GRÁN ÁREA METROPOLITANA (GAM) DE COSTA RICA PARA EL PERIODO 2000-2011
Authors: Arias Ramírez Rafael , Sánchez Hernández Leonardo
Published: November 2022

Este artículo es resultado de un estudio más amplio que se está realizando sobre patronesde concentración y evolución de la localización industrial y del mercado laboral en laGran Área Metropolitana (GAM) de Costa Rica y forma parte de la investigación queen economía regional ha venido realizando el Instituto de Investigaciones en CienciasEconómicas (IICE) de la Universidad de Costa Rica desde el año 2005. El presente artículoplantea una aproximación a la dinámica regional del empleo en la GAM durante el periodo2000-2011 mediante la aplicación del análisis Shift-Share en sus formulaciones clásica yespacialmente modificada. Esto permite descomponer el crecimiento del empleo en cuatroefectos: el efecto nacional, el efecto sectorial, el efecto regional o competitivo y el efecto“locacional”.
Integrative diagnostic criterion for evaluation of COVID-19 severity and the risk of post-COVID syndrome
Authors: Nesterova I. V. , Atazhakhova M. G. , Matushkina V. A. , Teterin Yu. V. , Gorodin V. N. , Chudilova G. A.
Published: November 2022

Pathophysiology of severe COVID-19 is characterized by changes in the number, phenotype, and function of neutrophil granulocytes (NG). Among the effector antiviral mechanisms of NG, the neutrophil extracellular traps (NETs) are among the most important features. However, their excessive formation exacerbates inflammation in acute respiratory distress syndrome and contributes to microvascular thrombosis. Their detection and counting may be important in severity grading of COVID-19, for determining correlations with clinical outcome, assessing the risk of developing post-COVID syndrome, and, possibly, for monitoring future targeted therapy. Purpose of our study was to develop a new diagnostic integrative criterion to assess the severity of COVID-19 and the risk of complications in the post-COVID period, including post-COVID signs in peripheral blood. Peripheral blood (PB) samples were studied from 31 patients with acute COVID-19 of moderate (n = 15) and severe degrees (n = 16). Moreover, we observed 52 patients discharged from the hospital after severe COVID-19, with diagnosed post-COVID syndrome (PCS) over the period of 30 to 60 days, and 100 healthy volunteers. The parameters of routine blood counts (MicroCC-20Plus) were evaluated, the leukocyte formula was calculated in PC smears, taking into account the number of formed NETs, and NGs entering pathological apoptosis. Based on the obtained results, an integral diagnostic criterion was calculated using the formula:

$$ IDK = \frac{\%\ unchanged\ NG}{\%NET + \%NG\ in\ apoptosis} $$

A 8.5-fold decrease in IDK index (p < 0.05) was shown in the cases of moderate-severity course of the disease, and a 30-fold drop was seen in severe cases (p < 0.05) compared with appropriate values in the group of healthy individuals. It was also found that, in 88.5% of patients with PCS after the SARS-CoV-2 infection, no morphologically altered NG were detectable in PB samples. At the same time, in 11.5% of patients with PCS, we found NETs and cells with pathological apoptosis, whereas IDC of NG-PCS was 8 times less than in the comparison group, and did not differ from the parameters of patients with moderate COVID-19 (p > 0.05) thus requiring further dispensary observation of such patients. The data obtained in this study indicate that the developed integrative diagnostic criterion allows us to assess both the severity of COVID-19 over acute period, and the risk of post-COVID syndrome. It should be emphasized that the characteristic changes in NG detected in COVID-19 may be readily identified in PB and consistently monitored by the proposed integral diagnostic criterion. A significant decrease in IDC indicates the persisting hyper-activation of NG and a need for targeted immunotherapy aimed at modulating the NG dysfunction.
CDR1, CDR2, MDR1 and ERG11 expression in azole resistant Сandida albicans isolated from HIV-infected patients in city of Moscow
Authors: Voropaev A. D. , Yekaterinchev D. A. , Urban Y. N. , Zverev V. V. , Nesvizhsky Yu. V. , Voropaeva E. A. , Likhanskaya E. I. , Afanasiev M. S. , Afanasiev S. S.
Published: November 2022

Candida fungi are common opportunistic microorganisms capable of causing infections of various localization, as well as life-threatening conditions in immunocompromised patients, such as HIV-infected individuals, oncology patients, subjects undergoing HSCT, which number has been steadily increasing in recent years. In addition, resistance to anti-fungal drugs has been spreading as well. Naturally sensitive to azoles, C. albicans possess a variety of mechanisms of acquired resistance, including efflux transporters and target protein-encoding gene amplification. This study was conducted to assess a prevalence of such mechanisms in the isolates sample obtained from HIV-infected patients in the Moscow region of the Russian Federation, characterize a relationship between these mechanisms and patterns of developing drug resistance. 18 strains of C. albicans resistant to fluconazole and voriconazole were isolated from HIV-infected patients with recurrent oropharyngeal candidiasis in the Moscow region. The expression levels of the ERG11, MDR1, CDR1, CDR2 genes involved in the formation of acquired azole resistance were measured using quantitative PCR, the 2CT method with ACT and PMA genes as control genes and reference values of sensitive isolates. Expression levels exceeding the average values of sensitive isolates by more than 3 standard deviations were considered significantly elevated. In most of the isolates, elevated levels of CDR1 and CDR2 gene expression were found: 89% and 78%, respectively. The expression level of the MDR1 gene was increased only in 28% of cases. ERG11 expression levels were significantly elevated in 78% of the isolates. Expression levels of all resistance genes studied were significantly increased in 4 strains. In this sample of C. albicans isolates, acquired resistance is mainly associated with efflux vectors encoded by the CDR1 and CDR2 genes. Also, in most isolates, an increased expression level for the azole target protein gene ERG11 was detected. The expression level of the efflux transporter gene MDR1 was increased in the smallest number of samples. It is also impossible to exclude a potential role of other mechanisms in developing acquired resistance, such as mutations in the ERG11 gene. It can be assumed that the identified mechanisms of resistance result from long-term, widespread, and sometimes uncontrolled use of azoles, including those in treatment and prevention of candidiasis in HIV-infected patients.
Evaluation of the effects in the in vitro system of synthetic thymic hexapeptide on the expression levels of NF-κB, IFNα/βR and CD119 neutrophilic granulocytes in patients with chronic herpes viral co-infections
Authors: Nesterova I. V. , Khalturina E. O. , Nelubin V. N. , Khaidukov S. V. , Chudilova G. A.
Published: November 2022

Background. Strategies used by herpes viruses with human cells are complex and multifaceted. On one hand, inborn defects in antiviral immune defense have been unveiled, which also affect interferon (IFN) system underlying development of chronic recalcitrant relapsing viral infections such as remittent respiratory viral infections, herpesvirus infections, and papillomavirus infections. On the other hand, numerous viruses are able to damage both immune system and IFN network. During inborn and acquired defects in IFN network, inborn or induced mutation in gene products involved in signaling cascades aimed at upregulating gene expression responsible for IFN production are observed. One of the strategies used by diverse viruses is altering some signaling pathways resulting in activated transcription factors including nuclear factor NF-kB. However, antiviral mechanisms executed by neutrophilic granulocytes (NGs), particularly affecting NF-kB expression have not been elucidated. Aim of the study: to study in vitro features of NF-kB expression and number of neutrophilic granulocytes (NG) expressing membrane IFN/R and IFNR in patients with atypical chronic active herpes virus infections (AChA-HVI), followed by assessing an effect of arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine hexapeptide (HP), a synthetic analogue of the active center of the thymopoietin (active substance of drug Imunofan, Russia), on the expression of NG NF-kB and IFN/R and IFNR. Materials and methods. We observed 25 patients of both sexes aged 23 to 64 years with AChA-HVI, manifested by chronic fatigue syndrome and cognitive disorders. Study design: stage 1 clinical, ELISA, PCR methods, FC was used. Stage 2 the in vitro experiment: 32 blood samples from 8 healthy adults and 375 blood samples from 25 patients with AChA-HVI were analyzed: % NG expressing NF-kB, IFN/R, IFNR and the relevant MFI levels by using FC before and after incubation with HP. Results. Our study demonstrated low level (MFI) of NF-kB expression in 100% NG associated with decreased % of NG expressing IFN/R and IFNR in all patients with AChA-HVI and low serum level for IFN and IFN in comparison with healthy individuals. In the in vitro experiment there was shown that 100% of NG expressed NF-kB after exposure to HP. However, only 48% patients (SG 2) restored NF-kB expression level (MFI) to normal range and 52% of cases (SG 1) had no response. HP increased % of NG expressing IFN/R in SG 2 and increased % of NG expressing IFNR in SG 1. Conclusions. It was shown, that influence of HP in vitro has ambiguous effects on the expression of NF-kB, % of NG expressing IFN/R and IFNR in patients with AChA-HVI. We assume that different NF-kB response to HP is associated with inborn or secondary NF-kB deficiency.
Obtaining and using erythrocyte antigenic meliidosis diagnostic agent in the analysis of serum samples from meliidosis-endemic provinces Ha Giang, Lang Son and Quang Ninh of the Socialist Republic of Vietnam
Authors: Tereshko D. L. , Novitskaya I. V. , Zakharova I. B. , Trien D. , Kuznetsov A. N. , Kulakov M. Ya. , Budchenko A. A. , Pushkar V. G. , Viktorov D. V. , Toporkov A. V.
Published: November 2022

Melioidosis is a particularly dangerous infection with endemic distribution caused by the Gram-negative microorganism from the pathogenicity group II Burkholderia pseudomallei. In endemic countries, melioidosis holds one of the leading places in mortality rate after HIV, tuberculosis and, in recent years, COVID-19. The natural ecological pathogen niches are located in tropical and subtropical climate zones, primarily in Southeast Asia and Australia, where its existence as a species is maintained in moist soil and water in a certain temperature environmental range. However, at present, more and more often cases of melioidosis are registered outside endemic territories, which emphasizes the relevance of improving the means and methods of laboratory diagnostics of this disease both for countries located in the zone of natural foci as well as for local healthcare of the countries after importation of this poorly known infection into their territory. In such countries, including the Russian Federation, the population has no natural immunity to the pathogen, and therefore this infection acquires even greater clinical and epidemiological significance. In the Volgograd Plague Control Research Institute, an erythrocyte antigenic melioidosis diagnostic agent for IHA was designed allowing to detect the presence of serum melioidosis antibodies. The diagnostic agent was obtained on the basis of a biological carrier ram erythrocytes sensitized with isolated protein antigenic complexes of B. pseudomallei. The high analytical characteristics of the diagnostic agent were confirmed on sera models of immunized and recovering experimental animals. Using the obtained set of reagents, the level of serum antibodies against the causative agent of melioidosis was studied in residents from the 3 provinces of Vietnam (Ha Giang, Lang Son and Quang Ninh), as well as in control group composed of residents of the Volgograd region. In samples obtained from a non-endemic region, not more than 25% of cases contained IHA titers at lower than 1:10 dilution, which is apparently due to cross-reactivity of serum immunoglobulins. Positive serum samples from clinically healthy residents of Ha Giang, Lang Son and Quang Ninh provinces were at a titer of 1:10 detected in 71.5%, in dilutions of 1:201:80 in 28.5% of cases. Thus, we believe that serum antibody titer of 1:80 established in the IHA results, has a diagnostic significance, reflecting the intensity of the anti-melioidosis populational immunity.
Reduced amino acid alphabet-based encoding and its impact on modeling influenza antigenic evolution
Authors: Forghani M. , Firstkov A. L. , Alyannezhadi M. M. , Danilenko D. M. , Komissarov A. B.
Published: November 2022

Currently, vaccination is one of the most efficient ways to control and prevent influenza infection. Vaccine production largely relies on the results of laboratory assays, including hemagglutination inhibition and microneutralization assays, which are time-consuming and laborious. Viruses can escape from the immune response that results in the need to revise and update vaccines biannually. The hemagglutination inhibition assay can measure how effectively antibodies against a reference strain bind and block an antigen of the test strain. Various computer-aided models have been developed to optimize candidate vaccine strain selection. A general problem in modeling of antigenic evolution is the representation of genetic sequences for input into the research model. Our motivation stems from the well-known problem of encoding genetic information for modeling antigenic evolution. This paper introduces a two-fold encoding approach based on reduced amino acid alphabet and amino acid index databases called AAindex. We propose to apply a simplified amino acid alphabet in modeling of antigenic evolution. A simplified alphabet, also called a sub-alphabet or reduced amino acid alphabet, implies to use the 20 amino acids being clustered and divided into amino acid groups. The proposed encoding allows to redefine mutations termed for amino acid groups located in reduced alphabets. We investigated 40 reduced amino acid sets and their performance in modeling antigenic evolution. The experimental results indicate that the proposed reduced amino acid alphabets can achieve the performance of the standard alphabet in its accuracy. Moreover, these alphabets provide deeper insight into various aspects of the relationship between mutation and antigenic variation. By checking identified high-impact sites in the Influenza Research Database, we found that not only antigenic sites have a significant influence on antigenicity, but also other amino acids located in close proximity. The results indicate that all selected non-antigenic sites are related to immune responses. According to the Influenza Research Database, these have been experimentally determined to be T-cell epitopes, B-cell epitopes, and MHC-binding epitopes of different classes. This highlighted a caveat: while simulating antigenic evolution, the model should consider not only the genetic information on antigenic sites, but also that of neighboring positions, as they may indirectly impact antigenicity. Additionally, our findings indicate that structural and charge characteristics are the most beneficial in modeling antigenic evolution, which is in agreement with previous studies.
Regulation of fluidity of high alumina matrix systems with various types of deflocculants
Authors: Trubitsyn M. A. , Furda L. V. , Volovicheva N. A. , Ustinova M. N.
Published: November 2022

Представлены результаты сравнительного анализа диспергирующего действия российских и зарубежных дефлокулянтов на основе полифосфатов и поликарбоксилатных эфиров (ПКЭ) на реологические свойства матричных систем высокоглиноземистого состава и их минеральных составляющих. Показано, что по дефлокулирущей способности отечественные ПКЭ не уступают аналогичным зарубежным продуктам и могут применяться для регулирования реологического поведения низкоцементных огнеупорных литейных масс.
Conformity of removable partial denture designs from three laboratories to a set of design principles
Authors: Daya Ruqaiya , Owen C. Peter
Published: November 2022

Purpose. The purpose of this study was to assess and to compare the technical quality of removable partial dentures (RPDs) servicing both public and private sectors in relation to biomechanically acceptable principles. A convenience sample of work carried out in three commercial dental laboratories servicing both the private and government sectors was used to provide a descriptive study of the laboratory stage of fabrication of RPDs over a 3-month period. Prescription sheets, master casts and completed dentures of 114 cases were evaluated and procedural and design-related information data were captured for each case. The results were disappointing in that not one of the RPDs evaluated conformed to commonly accepted principles. Not one dentist prescribed the design of the denture. Only one cast was surveyed to determine the path of insertion and any undercuts for the placement of clasps, yet 119 clasps were placed. Although 81 rests were used (in only 25 of the dentures), only 11 of those rests were pre-prepared on the teeth. Only 8 of the 95 acrylic-based dentures had any rests, making the remainder entirely mucosa-borne and therefore potentially iatrogenic.The study suggests that principles of RPD design taught during undergraduate training are not being adequately practised in both private and public sectors; and if practised the RPDs are not designed, nor constructed to requirements guided by design principles. Further training of dental technicians and clinicians is clearly indicated, and consideration should be given to a system of clinical audit to identify and prevent the malpractice observed in this study. In addition, ethical and legal guidelines emphasising the roles of clinicians and technicians in the prescription and design of RPDs in South Africa should be developed; and the mandatory comprehensive completion of laboratory work authorisation forms by dental clinicians should be considered.
Assessing the antibacterial properties of eggshell-titanium powder
Authors: Onwubu Stanley C , Mokgobole Mokgadi Ursula , Mdluli Phumlane Selby , Mokhothu Thabang Hendrica
Published: November 2022

The global distribution of oral diseases caused by bacterial and the severity of their consequences constitute a pandemic condition.The present paper reports on the antibacterial properties of a modified eggshell and titanium dioxide using the mechanochemical method. EB@TiO2 was modified and characterized using X-raydiffraction (XRD) while the degradation condition was studied using Thermogravimetric analysis (TGA).The inhibitory properties of EB@TiO2at differentconcentrations (2:1; 3:1 and 4: 1) against both Grampositive (E. coli) and negative bacterial (B. Cereus)strain were studied the using disk diffusion method.The XRD result confirmed the presence of a thermodynamically stable calcite structure, which is indicative of calcium carbonate. The diffraction peak of the XRD at 2θ = 29.5o suggests the deposition of TiO2 on the surface of CaCo3. TGA curves shows the decomposition of anatase form of titanium dioxide and calcium carbonate. The study evidently shows the antibacterial activities of EB@TiO2 against Escherichia coli and B. Cereus. The salient feature of the study finding is that modifying eggshells with titanium dioxide improves the antibacterial properties, and thus offers a promising role for the development of potent d
Desafios da pandemia na área da Reabilitação Neuropsicológica
Authors: Cruz Raquel Nogueira da , Magalhães Fernanda Lemes Batista , Menezes Anne Caroline de Oliveira , Silva Gabriela Souza , Santos Fernanda Rabelo Cursino , Oliveira Cecília Souza
Published: November 2022

INTRODUÇÃO: A Reabilitação Neuropsicológica (RN) pode ser definida como um processo Neuropsicológico, que visa promover uma melhor adaptação às dificuldades cognitivas e comportamentais do indivíduo. Com a pandemia, as técnicas da RN que eram realizadas de maneira exclusivamente presencial necessitaram ser adaptadas para uma forma remota. OBJETIVO: Diante disso, o objetivo do estudo foi criar um perfil no Instagram com a finalidade de divulgar, sem fins comerciais, a teoria e a prática da Reabilitação Neuropsicológica. Destaca-se que, nos dias atuais, o Instagram é a rede social mais utilizada no mundo, sendo, portanto, considerada um excelente meio de divulgação de conteúdos. METODOLOGIA: A metodologia é dividida: 1) define-se uma linha editorial dos principais conceitos acerca da RN, 2) é estabelecida um conjunto de técnicas e práticas de Reabilitação Neuropsicológica, no qual delimita-se qual função cognitiva será estimulada com aquela atividade, quais os procedimentos a serem utilizados e a qual público se destina (um dos pré-requisitos para os exercícios a serem apresentados é que sejam utilizados materiais de baixo custo e que possam ser realizados em casa), e 3) escrita dos textos e realização de vídeos utilizando a literatura científica como base. RESULTADOS E DISCUSSÃO: Até o presente momento, o perfil do Instagram conta com um público prioritariamente composto por alunos e profissionais envolvidos nas temáticas de estimulação, com uma média de acessos semanais de 1802 impressões. CONCLUSÃO: acredita-se que tem sido uma importante ferramenta de divulgação e aprendizagem das técnicas e dos conceitos da área de reabilitação neuropsicológica. Isso possibilita que alunos e profissionais se tornem ainda mais qualificados para atuarem na área.
Clinical profile and outcome of Guillain Barre syndrome in a tertiary care hospital
Authors: Sreekantham Sravya Sree , Rudrappa Sudha , Basauanagowsa Thanuja
Published: November 2022

Background: Guillain Barre syndrome (GBS) is a progressive symmetric muscular weakness with absent or depressed deep tendon reflexes. Wide spectrum of disease severity can be seen ranging from a mild disease to quadriparesis, cranial nerve involvement and autonomic instability. Methods: Hospital based observational study is planned for GBS patients admitted to Cheluvamba hospital, a tertiary care hospital in South India, for a period of 2.5 years from Jan 2020 to August 2022.Results: 30 patients (12 males; 18 females; mean age of 7.7 years) were enrolled in this study. Among which 11 were in age group of 0-5 (36%), 10 were in the age group of 6-10 (33%), 7 were in age group of 10-15 (23%), 2 were in age group 16 and above (6.6%). Type of paralysis was paraparesis in 14 (46%) children quadriparesis in 15 (50%) children and one child had no limb involvement. In associated dysfunctions, autonomic dysfunction was seen in 1 (4.5%), bulbar palsy in 3 (13.6%). One child presented with features of Miller Fischer variant of GBS which are ophthalmoplegia and ataxia. Among 30 children 22 were recovered and discharged, 3 children died, and 5 children left against medical advice.Conclusions: The clinical characteristics, subtype of GBS, and outcome vary according to geographic area. This study is directed to find the clinical pattern and outcome of the same in tertiary care hospital in south India.
Acalculous cholecystitis in the setting of immunoglobulin a vasculitis: a case report with literature review
Authors: Burruss Clayton Prakash , Bacus Ioana , Utamsingh Pooja Dushyant
Published: November 2022

Immunoglobulin A vasculitis (IgAV), also known as Henoch-Schönlein Purpura, is the most common childhood vasculitis which presents with a tetrad of symptoms: palpable purpura, abdominal pain, arthralgias, and renal involvement. Gastrointestinal involvement has been reported with findings including abdominal pain, pancreatitis, intussusception, ischemia, and gallbladder involvement. Our patient had the classical presentation of IgAV with additional gallbladder thickening found on imaging. He was managed conservatively for his symptoms and gallbladder thickening. This case adds to the six prior cases that we found in our literature search reported of gallbladder thickening alongside IgAV. However, this was the only case that was managed conservatively resulting in a complete resolution of symptoms.
Atypical presentation of thyroglossal cyst in pediatric patient: a case report
Authors: Narang Ekta , Tyagi Sonali , Jain Neha , Singh Jyoti
Published: November 2022

Thyroglossal duct cysts are the most common cause of congenital neck swelling that may present at any age. Classically, it presents as an anterior midline neck swelling that moves with protrusion of the tongue. The usual treatment of choice is Sistrunk operation. It can have atypical presentation requiring a thorough preoperative assessment before intervention. Here we discussed a case of atypical presentation of thyroglossal duct cyst in a 4 year old child.
PRÁTICAS AUTORREFERIDAS DE ENFERMEIROS SOBRE GERENCIAMENTO DE ANTIMICROBIANOS
Authors: Da Silva Felix Adriana Maria , Valentim Jarina Nathália , Scalon da Costa Perinoti Lívia Cristina , Sanches Couto Daniela , Dos Reis da Paz Beatriz , Moralez de Figueiredo Rosely
Published: November 2022

Objetivo: investigar as práticas autorreferidas de enfermeiros no Programa de Gerenciamento de Antimicrobianos (PGA). Método: estudo transversal, descritivo realizado no período de março a abril de 2021, com 40 enfermeiros de uma instituição privada de ensino superior da cidade de São Paulo. Os dados foram coletados por meio de instrumento estruturado e analisados por estatística descritiva. Resultados: Dentre as 14 práticas de enfermagem esperadas nos PGA, os participantes referiram aplicar oito (57,1%) frequentemente. Conclusão: os enfermeiros praticam parcialmente as atividades previstas nos PGA. Faz-se necessário avançar na abordagem dessa temática em sessões educacionais e durante a graduação para que as atividades sejam efetivamente incorporados na prática profissional do enfermeiro. 

Palavras-chave: Enfermeiro. Antimicrobianos. Programa de Gerenciamento do uso de antimicrobianos. Resistência antimicrobiana.
Lo justo y lo sublime: ética, derechos fundamentales y justicia premial. Interpretación IUS-filosófica desde Aristóteles
Authors: Villalobos-Antúnez José Vicente , Escobar-Zapa Carlos Andrés , Caldera-Ynfante Jesús Enrique , Díaz-Cid Luis
Published: November 2022

La investigación analiza el concepto de justicia en el contexto de la justicia premial consagrada en la legislación colombiana. El presente artículo, que hace parte de una investigación de mayor alcance, realiza primeramente un análisis del concepto de justicia en sentido filosófico, para luego analizar el concepto de justicia premial. Finalmente, se intercepta el concepto de justicia premial con el concepto más general de justicia, a partir de las nociones de paranomos y pleonektès de Aristóteles. Se concluye que el concepto de justicia premial se cataloga como una institución justa tal como la define este filósofo, por lo que no le es dado al intérprete desde esta perspectiva atribuir criterios de injusto a las decisiones que ponen fin a las controversias por intermedio de la justicia premial.
Beneficios tributarios y presión fiscal: antes y después de las reformas tributarias de 2012 y 2016
Authors: Rodríguez Liliana Heredia , Gómez Mejía Alina
Published: November 2022

Esta investigación analiza el impacto de los beneficios tributarios en la imposición efectiva de las empresas colombianas antes y después de las reformas tributarias de 2012 y 2016 en relación con el impuesto sobre la renta. El análisis se lleva a cabo empleando datos agregados de las declaraciones de renta y complementarios de personas jurídicas, publicados por la Dirección de Impuestos y Aduanas Nacionales (DIAN), de 2009 a 2020. Los resultados muestran que la imposición efectiva disminuyó o aumentó, en consonancia, con los cambios de la tasa nominal del impuesto sobre la renta para personas jurídicas, aunque no en la misma proporción y plantean que los beneficios tributarios vigentes cumplen su cometido de reducir la carga fiscal de los contribuyentes; no obstante, algunos sectores de la economía se vieron más favorecidos que otros.
Prophesying the End of Human Time: Eco-Anxiety and Regress in J. G. Ballard’s Short Fiction
Authors: Oramus Dominika
Published: November 2022

Despite being written half a century before the term “eco-anxiety” (Gifford and Gifford) was coined, J. G. Ballard’s disaster fictions can be read in the context of the social psychodynamics of climate change. My aim in this article is to demonstrate that in J. G. Ballard’s fiction, climate catastrophes and the devastation of nature cause the characters to realize that the Earth is not going to be able to sustain human life much longer, and their psychological reaction is either subdued anger or strange numbness. In order to do this, I analyze two short stories by Ballard: “Deep End” (1961) and “Low-Flying Aircraft” (1975) and show how their protagonists are affected by the landscape they inhabit: de-populated wastelands whose wildlife is extinct or mutated. I argue that it is their awareness that human civilization on earth is coming to its end that results in the state of mind akin to eco-anxiety. The characters are immersed in their own inner space and in these stories clocks mark not the passage from past to future but a countdown to the end.
Trust in Institutions and Tax Compliance. A Multilevel Analysis of the Regions of Spain
Authors: Cantero-Galiano Jesús
Published: November 2022

The purpose of the article/hypothesis: The aim of this work is to delve into the significance of trust in the phenomenon of tax compliance. Specifically, the relationship between taxpayers’ trust in the Government, administrations and institutions and their reported disposition towards tax compliance is explored based on the case of Spain and at regional level (NUTS2). Methodology: Using 2017 data collected by the European Values Study (EVS) and the Quality of Government Institute at the University of Gothenburg (QoG), a multilevel linear model is proposed where we assess the impact of citizen support for the Government and institutions on the disposition towards tax compliance. This model allows to simultaneously capture the relationships at taxpayer level and the effects of regional factors in the same equation. Results of the research: The results of the multilevel estimation allow the authors to reject the null hypothesis and accept, at least provisionally, the existence of a direct effect of trust in the institutions on tax compliance at regional level. Additionally, the low significance observed in the regional level variables suggests that citizens have non-decentralized perception of tax obligations. Furthermore, given that the effects are measured in terms of the quality of the institutions and government, the implications for regional policy and the actions of regional governments are of significant interest for the study of tax behavior and compliance.
Una reforma imposible : La justicia latinoaméricana en el banquillo
Authors: Pásara Luis
Published: November 2022

Este libro, escrito por Luis Pásara, está organizado en cuatro partes. La primera aborda la ineficacia de la ley en la vida social de un país y su repercusión en la administración de justicia. La segunda propone algunas claves de entendimiento de este problema. La tercera está dedicada a los intentos de reformar la justicia que se han desarrollado en las últimas tres décadas, sus logros y límites, los obstáculos encontrados en el camino y la experiencia de la reforma procesal penal. La cuarta y última pone atención a algunos actores relevantes del proceso y discute los mitos así como ciertas propuestas que circulan en torno al tema.
Las relaciones de poder en el Perú : estado, regiones e identidades locales siglos XVII-XIX
Authors: Mazzeo Cristina Ana
Published: November 2022

Este texto es el resultado de un proyecto de investigación cuyo objetivo fue el estudio de las relaciones de poder entre el Estado central y los poderes locales entre la época colonial y el periodo posterior a la Independencia. Desde diversas perspectivas, se estudian las cuatro ciudades más importantes del virreinato – Lima, Cusco, Arequipa y Trujillo, donde residieron élites que tuvieron una enorme importancia gracias al poder económico que detentaron y a su gravitación en la política local y la organización social en las regiones del norte, centro y sur del virreinato.
Maluliyet hesaplamasında göz önünde bulundurulan cetvellerde yer almayan arızaların değerlendirilmesi
Authors: ALTINDAĞ Hayrettin , ŞENOL Ender
Published: November 2022

Amaç: Maluliyet raporları, Adli Tıp’ın önemli çalışma alanlarından birisidir. Bu raporlar düzenlenirken kullanılan yönetmeliklerde eksiklikler olduğu bilinmektedir. Bu eksiklikler nedeniyle hak kayıpları yaşandığı, düzenleyen kurumun veya doktorun yönetmeliği yorumlarken kullandığı takdir farklılığından aynı olgu hakkında alınan raporlarda çelişkiler olduğu görülmektedir. Çalışmamızda yönetmeliklerin eksikliklerine dikkat çekmek, çelişkili raporlar düzenlenme nedenlerini araştırmak amaçlanmıştır.
Gereç ve Yöntem: Bu çalışmada; 01.01.2015-01.01.2020 tarihleri arasında Ege Üniversitesi Tıp Fakültesi (EÜTF) Adli Tıp Anabilim Dalında düzenlenen Maluliyet Raporları incelenerek raporlar içerisindeki ilgili yönetmelikte arıza karşılığı bulunmayan arıza çeşidi; ilgili yönetmelikte arıza çeşidine en yakın olarak takdir kullanılarak belirlenen toplam 542 adet rapor dahil edildi. Araştırmaya dahil edilen raporlar incelenerek, arızanın Meslekte Kazanma Gücü Kayıp Oranı Tespit Cetvellerine (MKGKOTC) ve Engel Oranları Alan Kılavuzuna (EOAK) göre hangi maddeye karşılık geldiği, kullanılan takdirin niteliği (oranlama, yakın takdir, eşik altı değer, karşılığı yok, karşılığı var) olgu rapor formlarına kaydedildi.
Bulgular: Çalışmaya dahil edilen MKGKOTC’ye göre en çok takdir kullanılan bölgelerin omuz eklemi (%15,5), diz eklemi (%13), ayak bileği (%12,5), el bileği (%8,5), kalça eklemi (%7,4), Ruh Sağlığı ve Hastalıkları (%6,5) olduğu görüldü. EOAK’ya göre en çok takdir kullanılan bölümlerin Kas İskelet Sistemi Arızaları (%77,7) olduğu görüldü. MKGKOTC’ye göre düzenlenen raporlarda yer alan arızalarda yakın takdir ve oranlama kullanımı anlamlı olarak yüksek bulundu (p<0.05).
Sonuç: Meslekte Kazanma Gücü Kayıp Oranı Tespit Cetvellerinin çağımızın gereklerini karşılayamadığı, eksiklikler nedeniyle bilirkişilerin takdir kullanmak zorunda kaldıkları görülmüştür. Yönetmeliğin; onu kullanan hekimin tecrübesi ya da uzmanlık alanı nedeniyle oluşan yorum farkına neden olması sonucunda, aynı arızaya sahip bir kişi için düzenlenen raporlarda dramatik farklılıklar oluşabilmektedir. Bu nedenle, yönetmelikte uzmanlık alanı ne olursa olsun aynı şekilde kullanılmasını sağlayabilecek bir düzenleme yapılması gerekmektedir.
Diversity and Potential Multifunctionality of Archaeal CetZ Tubulin-like Cytoskeletal Proteins
Authors: Brown Hannah J. , Duggin Iain G.
Published: November 2022

Tubulin superfamily (TSF) proteins are widespread and known for multifaceted roles as cytoskeletal proteins underpinning many basic cellular functions including morphogenesis, division, and motility. In eukaryotes, tubulin assembles into microtubules, a major component of the dynamic cytoskeletal network of fibres, whereas the bacterial homolog FtsZ assembles the division ring at midcell. Functions of the lesser-known archaeal TSF proteins are beginning to be identified, and show surprising diversity, including homologs of tubulin and FtsZ, and a third archaea-specific family, CetZ, implicated in the regulation of cell shape and possibly other unknown functions. In this study, we defined sequence and structural characteristics of the CetZ family and CetZ1 and CetZ2 subfamilies, identified CetZ groups and diversity amongst archaea, and identified potential functional relationships through analysis of the genomic neighbourhoods of cetZ genes. At least three subfamilies of orthologous CetZ proteins were identified in the archaeal class Halobacteria, including CetZ1 and CetZ2 and a novel uncharacterized subfamily. CetZ1 and CetZ2 were correlated to one another and to cell shape and motility phenotypes across diverse Halobacteria. Amongst other known CetZ clusters in orders Archaeoglobales, Methanomicrobiales, Methanosarcinales, and Thermococcales, an additional uncharacterized group from Archaeoglobales and Methanomicrobiales affiliated strongly with Halobacteria CetZs, suggesting they originated via horizontal transfer. Subgroups of Halobacteria CetZ2 and Thermococcales CetZ genes were found adjacent to different type IV pili regulons, suggesting a potential utilization of CetZs by type IV systems. More broadly conserved cetZ gene neighbourhoods included nucleotide and cofactor biosynthesis (e.g., F420) and predicted cell surface sugar epimerase genes. The findings imply that CetZ subfamilies are involved in multiple functions linked to the cell surface, biosynthesis and motility.
Etnografía histórica y otredades temporales. Migraciones a mediados del siglo XX
Authors: Sarricolea Torres Juan Miguel
Published: November 2022

El presente artículo es una reflexión sobre la etnografía histórica tomando como base la historia de la migraciones al norte de México por el boom algodonero y los Programas Braceros (1942-1964). Se detalla el recorrido metodológico emprendido por el autor y las discusiones teóricas en las que se apoya. Se argumenta que la etnografía histórica permite el análisis de la otred temporal, es decir, sujetos y espacios inscritas en temporalidades pasadas.
¿Existe asociación entre la rehabilitación orofacial con el menor tiempo de transición a la alimentación oral en recién nacidos prematuros con trastorno de succión del servicio de neonatología del Hospital Nacional María Auxiliadora del III nivel de atención entre enero y diciembre del 2021?
Authors:   , Barbieri Galecio Luciana Georgina
Published: November 2022

Objetivos del estudio: Determinar si existe asociación entre la rehabilitación orofacial con el menor tiempo de transición a la alimentación oral en recién nacidos prematuros con trastorno de succión del servicio de neonatología hospital nacional María auxiliadora del III nivel de atención entre enero y diciembre del 2021. Metodología: Es un estudio Observacional- Retrospectivo- Transversal -Analítico. Se tomará como población a recién nacidos prematuros < de 37 semanas de edad gestacional con diagnóstico de trastorno de succión del servicio de neonatología hospital nacional María auxiliadora del III nivel de atención entre enero y diciembre del 2021. El tamaño de muestra será de 76 participantes según la corrección de Fleiss, teniendo como tipo de muestreo probabilístico aleatorio simple. En el procesamiento de datos se utilizará el método manual mecánico, con el correspondiente paquete estadístico Stata V.16. En todos los análisis se considerará un valor p<0.05 con un intervalo de confianza de 95%. Y finalmente se expondrán los resultados.