bluuebunny/crossref_metadata_2025 huggingface dataset:
Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation
Authors: Kimura Yoshitaka , Yanagida Tamiko , Onda Akiko , Tsukui Daisuke , Hosoyamada Makoto , Kono Hajime
Published: January 2020

Objective:

Uric acid is supposed but not yet determined to be associated with atherosclerosis. Uric acid is released from damaged cells to form urate crystal, which is recognized by the immune system to produce IL (interleukin)-1. Danger signals and IL-1 have been shown to play an important role in atherosclerosis. We determined whether the physiological level of soluble uric acid promotes inflammation and develops atherosclerosis.

Approach and Results:

The secretion of IL-1β from human peripheral blood mononuclear cells mediated by NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome was promoted by physiological levels in serum uric acid. This augmentation of inflammation was mediated by the regulation of the AMPK (AMP-activated protein kinase)-mTOR (mammalian target of rapamycin) mitochondrial reactive oxygen species and HIF-1α (hypoxia-inducible factor-1α) pathway. In both of uricase transgenic and xanthine oxidase inhibitor–treated mice, decreased levels of uric acid resulted in the activation of AMPK and attenuation of the development of atherosclerotic plaques. Further, acute uric acid reduction by the administration of benzbromarone in healthy humans for 2 weeks significantly decreased plasma IL-18—an inflammasome-dependent cytokine.

Conclusions:

The data indicate that the development of atherosclerosis and inflammation is promoted by uric acid in vivo. Moreover, the lowering of uric acid levels attenuated inflammation via the activation of the AMPK pathway. This study provides mechanistic evidence of uric acid–lowering therapies for atherosclerosis.
Interleukin-1 Beta–Mediated Sex Differences in Kawasaki Disease Vasculitis Development and Response to Treatment
Authors: Porritt Rebecca A. , Markman Janet L. , Maruyama Daisuke , Kocaturk Begum , Chen Shuang , Lehman Thomas J.A. , Lee Youngho , Fishbein Michael C. , Noval Rivas Magali , Arditi Moshe
Published: January 2020

Objective:

Kawasaki disease (KD) is the leading cause of acute vasculitis and acquired heart disease in children in developed countries. Notably, KD is more prevalent in males than females. We previously established a key role for IL (interleukin)-1 signaling in KD pathogenesis, but whether this pathway underlies the sex-based difference in susceptibility is unknown.

Approach and Results:

The role of IL-1 signaling was investigated in the
Lactobacillus casei
cell wall extract-induced experimental mouse model of KD vasculitis. Five-week-old male and female mice were injected intraperitoneally with PBS,
Lactobacillus casei
cell wall extract, or a combination of
Lactobacillus casei
cell wall extract and the IL-1 receptor antagonist Anakinra. Aortitis, coronary arteritis inflammation score and abdominal aorta dilatation, and aneurysm development were assessed. mRNA-seq (messenger RNA sequencing) analysis was performed on abdominal aorta tissue. Publicly available human transcriptomics data from patients with KD was analyzed to identify sex differences and disease-associated genes. Male mice displayed enhanced aortitis and coronary arteritis as well as increased incidence and severity of abdominal aorta dilatation and aneurysm, recapitulating the increased incidence in males that is observed in human KD. Gene expression data from patients with KD and abdominal aorta tissue of
Lactobacillus casei
cell wall extract-injected mice showed enhanced
Il1b
expression and IL-1 signaling genes in males. Although the more severe IL-1β–mediated disease phenotype observed in male mice was ameliorated by Anakinra treatment, the milder disease phenotype in female mice failed to respond.

Conclusions:

IL-1β may play a central role in mediating sex-based differences in KD, with important implications for the use of anti–IL-1β therapies to treat male and female patients with KD.
The Role of the Epicardium During Heart Development and Repair
Authors: Quijada Pearl , Trembley Michael A. , Small Eric M.
Published: January 2020

The heart is lined by a single layer of mesothelial cells called the epicardium that provides important cellular contributions for embryonic heart formation. The epicardium harbors a population of progenitor cells that undergo epithelial-to-mesenchymal transition displaying characteristic conversion of planar epithelial cells into multipolar and invasive mesenchymal cells before differentiating into nonmyocyte cardiac lineages, such as vascular smooth muscle cells, pericytes, and fibroblasts. The epicardium is also a source of paracrine cues that are essential for fetal cardiac growth, coronary vessel patterning, and regenerative heart repair. Although the epicardium becomes dormant after birth, cardiac injury reactivates developmental gene programs that stimulate epithelial-to-mesenchymal transition; however, it is not clear how the epicardium contributes to disease progression or repair in the adult. In this review, we will summarize the molecular mechanisms that control epicardium-derived progenitor cell migration, and the functional contributions of the epicardium to heart formation and cardiomyopathy. Future perspectives will be presented to highlight emerging therapeutic strategies aimed at harnessing the regenerative potential of the fetal epicardium for cardiac repair.
Effects of Polyethylene Glycol‐20k on Coronary Perfusion Pressure and Postresuscitation Myocardial and Cerebral Function in a Rat Model of Cardiac Arrest
Authors: Ge Weiwei , Zheng Guanghui , Ji Xianfei , He Fenglian , Hu Juntao , Bradley Jennifer L. , Moore Christine E. , Peberdy Mary A. , Ornato Joseph P. , Mangino Martin J. , Tang Wanchun
Published: January 2020

Background

Epinephrine increases the rate of return of spontaneous circulation. However, it increases severity of postresuscitation myocardial and cerebral dysfunction and reduces duration of survival. We investigated the effects of aortic infused polyethylene glycol, 20 000 molecular weight (
PEG
‐20k) during cardiopulmonary resuscitation on coronary perfusion pressure, postresuscitation myocardial and cerebral function, and duration of survival in a rat model of cardiac arrest.

Methods and Results

Twenty‐four male rats were randomized into 4 groups: (1)
PEG
‐20k, (2) epinephrine, (3) saline control–intravenous, and (4) saline control–intra‐aortic. Cardiopulmonary resuscitation was initiated after 6 minutes of untreated ventricular fibrillation. In
PEG
‐20k and Saline‐A, either
PEG
‐20k (10% weight/volume in 10% estimated blood volume infused over 3 minutes) or saline was administered intra‐aortically after 4 minutes of precordial compression. In epinephrine and placebo groups, either epinephrine (20 μg/kg) or saline placebo was administered intravenously after 4 minutes of precordial compression. Resuscitation was attempted after 8 minutes of cardiopulmonary resuscitation. Sublingual microcirculation was measured at baseline and 1, 3, and 5 hours after return of spontaneous circulation. Myocardial function was measured at baseline and 2, 4, and 6 hours after return of spontaneous circulation. Neurologic deficit scores were recorded at 24, 48, and 72 hours after return of spontaneous circulation. Aortic infusion of
PEG
‐20k increased coronary perfusion pressure to the same extent as epinephrine. Postresuscitation sublingual microcirculation, myocardial and cerebral function, and duration of survival were improved in
PEG
‐20k (
P
<0.05) compared with epinephrine (
P
<0.05).

Conclusions

Aortic infusion of
PEG
‐20k during cardiopulmonary resuscitation increases coronary perfusion pressure to the same extent as epinephrine, improves postresuscitation myocardial and cerebral function, and increases duration of survival in a rat model of cardiac arrest.
What Kind of Poetry Would a Syriac Manuscript-Thief Read about Oneself?
Authors: Pritula Anton
Published: January 2020

In the modern period, numerous notes appeared within the colophons, aiming to protect a manuscript from potential thieves by addressing various curses to them. Some of those curses obtained a verse form, mainly forming quatrains, the most popular genre form, suitable for various kinds of notes. The paper discusses a such pieces – never studied of published so far – that were composed and written by a scribe named Hōrmīz, son of ‘Abd al-Aḥad, who worked in the early 18th century in Kirkuk (Syriac Bēt Slōk),
A new species of Leptomenes Giordani Soika from Uganda (Hymenoptera: Vespidae: Eumeninae)
Authors: SELIS MARCO
Published: January 2020

Leptomenes Giordani Soika, 1939 is an Afrotropical genus of small-sized potter wasps, presently comprising eight species in continental Africa and another three species in Madagascar. The continental species are mainly distributed in eastern Central Africa, but some species reach Kwazulu-Natal in the south and Senegal in the west (Carpenter et al. 2010).
Protosticta joepani sp. nov. from Borneo with notes on P. kinabaluensis Laidlaw, 1915 (Odonata: Zygoptera: Platystictidae)
Authors: DOW RORY A. , PHAN QUOC TOAN , CHOONG CHEE YEN
Published: January 2020

Protosticta joepani sp. nov. is described from Malaysian Borneo (holotype male Bario, Kelabit Highlands, Miri Division, Sarawak, Malaysia, deposited in the Naturalis Biodiversity Center, Leiden). It is the sister species of P. kinabaluensis Laidlaw, 1915; some descriptive notes and a set of illustrations are provided of the latter species. A COI gene tree for both species is provided. The placement of both P. joepani and P. kinabaluensis is discussed, but although it is very unlikely that they belong in Protosticta sensu stricto, the issue is left open here.
New Caddisflies (Insecta, Trichoptera) from the Krabi and Phang Nga Provinces, southern Thailand
Authors: MALICKY HANS , IVANOV VLADIMIR D. , MELNITSKY STANISLAV I.
Published: January 2020

An updated list of the caddisfly species occurring in Krabi and Phang Nga Provinces, southern Thailand, comprises 76 species. Among them, 69 species are found in Krabi Province and 17 in Phang Nga Province, 4 are new for science and 2 new for Thailand. New species from the families Hydroptilidae (Hydroptila nevdomek sp. n.), Polycentropodidae (Nyctiophylax dosyhpor sp. n.), Psychomyiidae (Psychomyia dabudettak sp. n.), and Leptoceridae (Setodes pokamest sp. n.) are described. Hydroptila namcattien Malicky & Chantaramongkol 2007 and Setodes kybele Malicky & Chantaramongkol 2006 are new species for Thailand. Faunistic considerations and comparisons to other regions of Thailand are provided.
Gold Nanorods Combined with an Near Infrared Laser for the Establishment of a Precise Posttraumatic Osteoarthritis Model
Authors: Wu Zizheng , Wu Jianxin , Zhao Jingpeng , Kang Yingjie , Wang Jiaqi , Wang Qiugen , Deng Guoying
Published: January 2020

Objective: To investigate the innovative application of gold nanorods combined with a laser in posttraumatic osteoarthritis (PTOA) modeling and to discuss the possible mechanisms. Methods: Electron microscopy was used to characterize the gold nanorods. Cell counting kit-8
assay and enzyme-linked immunosorbent assay were used to evaluate cell proliferation and cytotoxicity. An infrared spectroscopy (IR) thermal camera was used to monitor the temperature changes of gold nanorods with or without the laser treatment. Furthermore, western blotting was used to evaluate
the expression of related proteins in response to the indicated treatments. Finally, microcomputed tomography (micro-CT) was used to determine the structural changes in knee joints. Changes in the cartilage and various other tissues were assessed by histological examination. Results:
The characteristics and biosafety of the gold nanorods were confirmed. Our study showed that gold nanorods combined with the laser inhibited cell viability, but the gold nanorods or laser alone did not affect cell viability. Moreover, the effect on cell viability was time dependent. Similarly,
only gold nanorods with the laser caused the apoptosis of cartilage cells and the upregulation of IL-1β, MMP-13 and Comp. We injected gold nanorods and used laser irradiation to develop an osteoarthritis (OA) model. The temperature of the knees in the OA model increased to 60 °C
and then remained at approximately 60 °C. As the time increased, gold nanorods combined with the laser caused more injuries and degeneration in the knee joints. Conclusion: OA models that were established using gold nanorods and a laser were precise, controllable, observable and
stable and could be an excellent premise for investigating the exact mechanisms underlying OA and exploring new treatment strategies.
Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin
Authors: He Yihong , Wu Cong , Duan Jiayu , Miao Junming , Ren Hongyu , Liu Jiagang
Published: January 2020

Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation.
In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after
the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex, tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis in vivo. The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy
of GBM.
Production of Orthophoto Map Using Unmanned Aerial Vehicles Photogrammetry
Authors: Ngadiman Norhayati , Kaamin Masiri , Hamid Nor Baizura , Sahat Suhaila , Mokhtar Mardiha , Kadir AslilaAbd , Nor Ahmad Hakimi Mat
Published: January 2020

Orthophoto is a part of the process of concept of photogrammetry in map production. Orthophoto image is a specific scaled photographic image produced from perspective images in which distortion errors originating from the attitude differences and the tilt of image are eliminated while
orthophoto map is an orthophoto that has cartographic information on it (legend, grids, contours, labels, etc.). The development of current technology has introduced the Unmanned Aerial Vehicles (UAV) as an alternative to conventional photogrammetry in creating orthophoto map. Purpose of this
paper is to identify the potential of Unmanned Aerial Vehicles (UAV) as an alternative to conventional photogrammetry which uses aircraft in creating orthophoto map. The area of the study is UniversitiTun Hussein Onn Malaysia (UTHM) Pagoh Campus within Pagoh Educational Hub. UAV photogrammetry
based on a photogrammetricmeasurement platform, which operates remotely controlled, semi-autonomously, or autonomously, without a pilot sitting in the vehicle. The large format aerial camera in conventional photogrammetry is replaced with small format digital camera in UAV photogrammetry.
For general area, the amount of forward overlap and side overlap is 75% and 60% respectively. For forest area, the amount of forward overlap and side overlap is 85% and 70% respectively as the UAV flight altitude will be higher. The whole workflow is introduced in the paper, where 461 images
were collected with DJI Phantom 4 Pro with camera model FC6310. The flight mission was completed using PIX4D Capture. An orthophoto map covering an area of 250458 m2 was produced using AgisoftPhotoScan. The result from this study produces a better quality orthophoto map of UTHM Pagoh Campus.
This map will shows the overview of the campus area with the most updated information.
Analysing and Forecasting Share Price Index in Malaysia
Authors: Mohamed Hafiz Nur Afiqah , Ishak Norizarina , Nurullah Rasedee Ahmad Fadly
Published: January 2020

Wilkie investment model is a stochastic investment model that was built by Wilkie in 1984 and was updated in 1995. The model building objective is forecasting. Box-Jenkins method was the basic structure of Wilkie model. It involves various type of forecasting model. Some model handle
stationary time series such as autoregressive moving average (ARMA) model while some of them handle non-stationary time series such as autoregressive integrated moving average (ARIMA) model. There are four sub-models in the Wilkie model which is retail price index model, share dividend yield
model, share dividend index model and Consols yield model. In this paper, the Wilkie share price model [4] was apply to Malaysia data in analysing and forecasting FTSE Bursa Malaysia KLCI share price index for 36 month ahead from November 2015 to October 2018. Monthly historical data from
January 1996 to October 2015 are use as the base. We use ARIMA model to forecast the share price index in Malaysia. ARIMA(0,1,2) model was chosen as the best fit forecasting model. Through forecasting, we are able to evaluate the performance of the share price index in Malaysia.
Senior Driver Performance on Airport Road Access Wayfinding Design
Authors: Anuar Nur Khairiel , Sabar Rohafiz , Mutazam Mazli
Published: January 2020

The purpose of this study was to evaluate the wayfinding and signage provisions, sensitivity of senior driving behavior and road safety. Three scenario types were designed using driving simulator to simplify the airport navigation and driving complexity of the road designs to the airport.
An assorted road furniture was included on alternative airport road access to provide a variety of wayfinding complexity. Fifteen experience car drivers in range of age 50–54, 55–59 and over 60 years were selected to perform the study. Participants were asked to drove for approximately
20 minutes to complete the simulated driving. The types of errors (parameter) of simulated driving were identified, evaluated and compared to the age group. Results were analyzed by ANOVA and discussed with reference to the use of driving simulator. The ANOVA confirmed that senior drivers’
age group have no significant effect on the airport road design, wayfinding and all research parameters; risk of collisions, exceed the speed limit, traffic light tickets, centerline crossings and road edge excursions.
Application of Technique for Order Preference by Similarity to Ideal Solution Multi-Criteria Decision-Making Method for Financial Performance Evaluation: A Case Study of Services Sector in Malaysia
Authors: Fahami Norasyikin Abdullah , Azhar Farah Waheeda , Abd Rahim Zati Halwani , Abd Karim Hilwana , Nor Abdul Rahim Zati Siti Khatijah
Published: January 2020

This paper aims to evaluate financial performance of companies from services sector in Malaysia using TOPSIS multi-criteria decision-making method. Financial data of 10 companies in 2017 are retrieved from DataStream. For many years, financial ratios are used to analyse financial performance
of a companies. However, some studies indicate that traditional ratio analysis is insufficient to measure firm’s financial performance. Thus, this paper applies Technique for order Preference by Similarity to ideal Solution (TOPSIS) to obtain a more comprehensive result. This TOPSIS
approach which involves seven step utilizes financial ratios such as current ratio, acid test ratio, debt ratio, debt to equity ratio, return on asset (ROA), return on equity (ROE) and earnings per share (EPS) as criteria to evaluate the companies’ financial performance. The ultimate
finding of this study is the ranking of the companies which also suggest the investor on which companies to invest based on their financial performance. The results from this research are found to be consistent with the analysis by various investment agencies. Thus, this approach can be used
as an alternative to the traditional valuation that has been used before.
Decision Support System for Determining Pharmacy Service Quality
Authors: Irawan Dedi , Huda Miftachul , Teh Kamarul Shukri Mat , Ihwani Siti Suhaila , Rashid Mohd Hambali , Febriana  , Maseleno Andino
Published: January 2020

Service quality of a trading company affects the level of customer satisfaction. The better the service quality, the higher the level of customer satisfaction. A high level of satisfaction allows the increase of consumers in the company concerned. Evaluation of service quality at Among
Rogo Pharmacy is very necessary because the results of the evaluation can be used as a reference to determine policies related to the efforts in improving service quality. This research was conducted using SAW (Simple Additive Weighting) method. This method was chosen because it was able to
select alternatives from a number of alternatives. The intended alternative is the level of service quality, namely: (1) Very Bad, (2) Bad, (3) Fair, (4) Good, (5) Very Good. Evaluation results based on observations of Among Rogo Pharmacy were also calculated along with these alternatives
and alternatives whose value close to the calculation service evaluation results at Among Rogo Pharmacy. There were considered true to determine the quality of service at Among Rogo Pharmacy. This system can still be developed again by adding weight of the criteria, or by using other methods.
Quantifying Indicators of Supply Risk in Power Generation System Using Risk Impact Matrix (PICOST)
Authors: Tufail M. M. B. , Ibrahim A. J. , Melan M.
Published: January 2020

In the recent years the huge diffusion of technology emerges need of energy security more than ever before. Secure supplies at affordable cost are the key to sustainable economic growth. Planning an uninterrupted and affordable generation portfolio with minimum level of inherent risk
is the top priority of policy maker around the globe. However so far very few work have been done on the evaluation of risk in power generation. It is a well-known fact that highly secured system bears excessive cost. This paper will propose an idea for radical evaluation of exposed risk to
diverse power generation resources. It highlights the process of identification, evaluation and estimation of risk and proposed a semi quantitative risk impact matrix approach to quantify the loss of generation caused due to unforeseen events.
Understanding Users’ Intention to Use Open Government Data with Perceived Risk as Moderator: A Conceptual Model
Authors: Ahmed Mohammed Shihab , Mahmuddin Massudi , Mahat Nor Idayu
Published: January 2020

Government become part of social life, open government data is the best way provide a better understanding of user’ intention to use open government data this study proposed a framework that can enhance the intention of open government data users. This study used Expectation Confirmation
Theory (ECT) and suggested that expectation, confirmation, perceived performance and incentive on usage can be a significant predictor of users’ behavioural intention to use open government data which influence the user satisfaction from open government data. Furthermore, the current
study proposed the moderating effect of perceived risk on the relationship between expectation, confirmation, perceived performance, incentives on usage and user’s behavioural intention. This study provides important implications for the open government data agencies and an avenue for
academia and practitioners to further test the proposed empirically to test the proposed framework.
Design of an Agent Based Analysis Approach for Secure Communication Against the Existing of Selfish Node Attack
Authors: Sumiti  , Mittal Sumit
Published: January 2020

The internal participating nodes in mobile network can be affects fully or partially by selfish nature to improve its own communication rate. This nature can degrade the forwarding rate and affects the overall performance of the network. The detection of such selfish nodes is required
to improve the communication throughput and network performance. In this paper, an Agent based analysis approach is defined to detect the selfish node in the network. The fuzzy based zonal analysis method is suggested to perform the zonal evaluation on the mobile network. The distributed Agents
performed the analysis on the fuzzy based communication parameters. The parameter specific evaluation method is able to separate the good and selfish nodes. Once the selfish nodes are identified, the preventive route formation is done for safe communication. In this paper, the Agent adaptive
model is presented for detection and prevention of selfish nodes. The proposed Agent adaptive model is simulated in NS2 environment. The comparative results are generated against token based, agent based and watchdog methods. The analysis results show that the proposed protocol has achieve
the 17% improvement in packet communication, 37% reduction in communication loss and 53ms reduction in packet delay.
A Survey on Deep Learning Techniques for Prognosis and Diagnosis of Cancer from Microarray Gene Expression Data
Authors: Shahane Rahul , Ismail Md. , Prabhu C. S. R.
Published: January 2020

The gene expression classification and identification from DNA microarray data is efficient technique for cancer diagnosis and prognosis for specific cancer subtypes. DNA microarray technology has great potential to discover information from expression levels of thousands of gene. The
collection of significant genes which can improve the accuracy can give proper direction in early diagnosis of cancer. Cancer may be of different subtypes. Cancer detection from microarray gene expression data has major challenge of low sample size, high dimensionality and complexity of the
data. There is a need for fast and computationally efficient method to deal with these kind of challenges. Deep Learning has succeeded in numerous fields such as image, video, speech, and text processing. Gene expression analysis is a unique challenge to Deep Learning for various cancer detection
and prediction tasks in order to set specific biomarkers for different cancer subtypes. In this paper, we briefly discuss the strengths of different Deep Learning architectures for a cancer detection and prediction of various types of cancer through gene expression analysis.
Investigation and Electrodeposition Rate Optimization of Au–Cu Alloy Co-Deposition
Authors: Babaei Hamid , Sovizi Mohamad Reza , Khosravi Morteza , Khorami Saeed Abedini
Published: January 2020

In the present study, influence of effective parameters on electrochemical deposition rate optimization of alloy Co-deposition. Main parameters in this method include current density direct, concentration of Au, Cu ions, solution pH, agitation, and effect of additive that are effectively
optimized using “one-factor-at-a-time” method to achieve Au–Cu electrochemical alloy deposition with 18 carat (750 part in a hundred part Au in weight basis, according to the carats of formal national and international standards) and proper electrodeposition rates of 6 mA/cm2,
6 gr/lit, 55 gr/lit, 24 gr/lit, 66 °C, 12.3, 100 rpm and 1 gr/lit, respectively. Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDS), inductively coupled plasma-optical emission spectrometry (ICP-OES), and X-ray fluorescence (XRF) characterization methods were
used in study of electrochemical deposition influence on cross sections of the deposited layers. In this method, results indicates that electrodeposition rate in optimum conditions and approximate karat of 750 K, with direct current (6 mA/cm2) in 4 hours is 0.841 μm/min.
In this work, deposition rate has increased significantly compared to commercial methods 1 μm/3–7 min. Percentages of Au in deposited layers were compared through inductively coupled plasma-optical emission spectrometry (ICP-OES) and X-ray fluorescence (XRF) characterization
methods, but ICP-OES is a more accurate method.
The Effect of Time and Volume Stater of Bioethanol Content from Coconut Fiber Waste and Mengkudu
Authors: Herawati Netty , Muplih Muh A. P. , Iqbal Satriansyah M. , Roni Kiagus A.
Published: January 2020

Mengkudu and coconut fiber are a plant which frequently find in Indonesia. Mengkudu is a plant that has many advantages and carbohydrate content as 51,67%. Coconut fiber has high enough cellulose content as 43,44%, with high carbohydrate content and high cellulose content they can be
utilized as basic ingredient in the making of bioethanol. The purpose of this research is to determine the best condition in the process of making bioethanol from them. Bioethanol was made by fermentation which was helped by bactery, that was Saccaromyches cerevisae or often known as
bread yeast. The results of this research were obtained fermentation time and volume of the stater used in making bioethanol from mengkudui fruit in order to get the best content bioetanol is in 60 hours using a stater volume of 10% which produces 6.26% bioethanol, while for the manufacture
of bioethanol from waste Coconut coir is at 72 hours using a 6 gr volume of starch which produces bioethanol 13.80%.
The Role of the Subject “Mathematics” Content in the Learning Motivation
Authors: Timerbaeva Nailya Vakifovna , Fazleeva Elmira Ildarovna , Shakirova Kadriya Barievna
Published: January 2020

The future of any country depends on the quality of education, in particular, mathematics. This paper represents an investigation of the possibilities of using motivation, which is one of the main conditions for improving the quality of teaching mathematics. Educational motivation,
as a particular type of motivation, is determined by many factors: the educational system, the organization of the learning process, the subjective characteristics of a student and teacher. In our opinion, the factor associated with the very specificity of the subject matter “mathematics”
remains insufficiently studied. Experience has shown that practice teachers and beginning teachers underestimate the role of motivation in teaching mathematics. They unconsciously or quite consciously skip the stage of motivation when introducing mathematical concepts, studying theorems, etc.,
not seeing the potential of the subject matter for the implementation of motivation. The purpose of the study is to identify the capabilities of the subject matter “mathematics” in the implementation of motivation, as well as the pedagogical conditions for preparing future teachers
for its implementation. The research methods for this problem are the theoretical analysis of the knowledge of this issue, questionnaires, overt observation. The study showed that students and beginning teachers knowing the general techniques and methods of motivation do not see the potential
possibilities of the subject of mathematics and specific topics for its implementation. At the same time, we have established that motivation can be carried out at any stage of training: by introducing mathematical concepts, algorithms, studying methods of action, methods for solving problems
and theorems. Improving the training of future mathematics teachers is associated with the development of mathematical, pedagogical and methodological thinking of students, allowing motivation to introduce to study mathematics as a subject. To do this, in the classes on the teaching methodology,
it is worth to purposefully teach the methods of motivation for educational activity in all substantive lines of the school course in mathematics to supplement the training content with courses on the choice of “Methods of student motivation,” “The role of motivation in teaching
mathematics,” “Motivation for learning through the content of the subject.
Reallocated Sectors Count Parameter for Analysing Hard Disk Drive Reliability
Authors: Nasyrov Iskandar Nailovich , Nasyrov Ildar Iskandarovich , Nasyrov Rustam Iskandarovich , Khairullin Bulat Askarovich
Published: January 2020

The dependence of the SMART parameter 5 Reallocated sectors count value change on the operating time characterising the number of reallocated sectors is considered. This parameter is critical in the sense that if the attribute value increases, this may indicate deterioration in the
state of the disk surface. The scientific task of the study is to establish relationships in the failed hard drives between the specified parameter and the values of other reliability parameters for information stores of various manufacturers. In the course of the study, the drives of the
HGST, Hitachi, Samsung, ST, Toshiba, WDC trademarks operated in the Backblaze largest commercial data centre were analysed. The analysis revealed a relationship between the specified parameter and the parameters 1 Read error rate (frequency of errors (when reading data from the disk), the
origin of which is due to the hardware of the disk), 196 Reallocation event count (number of reallocation operations), 197 Current pending sector count (number of sectors that are candidates for reallocation). It is shown that the nature of the change in the values of the considered parameters
depends on the manufacturer of information storage devices. It is proposed to perform an individual assessment of the reliability of hard drives using the parameters identified as a result of the study.
Experimental Study on Biomedical Signal Acquisition of Sports Fatigue
Authors: Chi Mingli
Published: January 2020

To explore the biomedical signal acquisition of sports fatigue, the Pclab-UE biomedical signal acquisition and processing system is used to collect and process heart rate variability (HRV) automatically after quiet and fatigue exercise. In the meanwhile, the experimental data are analyzed.
The heart rate variability of the subjects is recorded, aiming to provide experimental evidence for the future application of HRV in the diagnosis of exercise fatigue. Moreover, it also provides a noninvasive diagnostic index for exercise fatigue and exercise training practice. The research
results showed that, the HRV values in the sub-maximal exercise caused fatigue. The maximal exercise induced fatigue is significantly decreased and there are significant differences. As a result, it is summed up that we can use HRV as a quantitative analysis index for the diagnosis of sports
fatigue.
A Novel High Frequency Low Voltage Low Power Current Mode Analog to Digital Converter Pipeline
Authors: Bchir Mounira , Ettaghzouti Thouraya , Hassen Néjib
Published: January 2020

This paper introduces a novel structure for the realization of a low voltage, low power current-mode analog to the digital converter (ADC) pipeline (12 bits). The proposed structure of the ADC is based on a novel design of a current comparator and Digital to Analog Converter (DAC) structure.
This modification allows us to reach a higher speed, lower voltage, and lower power dissipation. ELDO simulators using 0.18 μm, CMOS and TSMC parameters are performed to confirm the workability of this architecture. The proposed ADC is powered with a 1 V supply voltage. It is characterized
by wide conversion frequency (350 MHz) and low power consumption that is 2.76 mW.
Role of miR-139-5p in relieving renal allograft ischemia-reperfusion injury by inhibiting c-Jun NH-terminal kinase (JNK) signaling pathway
Authors: Zhang Yan , Wang Shu , Yang Ping , Wang Tao
Published: January 2020

Renal ischemia-reperfusion injury cannot be avoided in the process of kidney transplants. In this study, the role of miR-139-5p in renal ischemia-reperfusion injury in mice was investigated. Hyperuricemia cells were detected using qPCR. The results confirm that the expression levels
of miR-139-5p, Jun, and c-Jun were detected, and miR-139-5p was down-regulated in the ischemia-reperfusion injury after renal transplantation, while CDK4 and Jun were up-regulated. The levels of [Ca++]i and ROO were measured in HK-2 cells, and it was determined that overexpression
of miR-139-5p reduced these levels to approach a normal state. After cell silencing of miR139-5p, the levels of [Ca++]i and ROO of the hyperuricemia cells increased significantly. After down-regulation of miR-139-5p via CCK-8 and clonal cell formation assays, it was determined that
the survival rate and viability of hyperuricemia cells were decreased significantly. However, the addition of the agent anisomycin (JNK activation) improved the survival rate of hyperuricemia cells and increased their viability. The detection of the cycle of the hyperuricemia cells revealed
that the up-regulation of miR-139-5p blocked a large number of cells in the G1 phase; however, the number of these cells significantly decreased after the addition of anisomycin. The expression levels of c-Jun and JNK in hyperuricemia cells were detected via immunofluorescence. In the hyperuricemia
cells, the fluorescence intensity in the miR-139-5p overexpression group was higher compared to that in the control group. Moreover, the fluorescence intensity decreased significantly after the addition of anisomycin. Nano-magnetic beads were fabricated and used to extract high purity RNA.
Scanning electron microscopy was used to confirm the efficacy of the nanoparticles in the extraction of RNA. The detection of the JNK pathway-related proteins of hyperuricemia cells using qPCR and Western blot revealed that the downregulation of miR-139-5p promoted the expression of JNK pathway-related
proteins while the up-regulation of miR-139-5p inhibited the expression levels of c-jun, JNK, JNK 1, and JNK 2. The experimental results indicate that miR-139-5p alleviates renal–renal ischemia-reperfusion injury by targeting Jun-mediated JNK signaling pathways.
Study on the transfer and anchorage length of steel strand in ultra high performance concrete material
Authors: Zheng Hui , Zhou Dongdong , Yin Xinfeng , Wang Lei
Published: January 2020

Ultra-high-performance concrete (UHPC) material, a new type of cement-based composite material, is usually employed in the bridge engineering. The transfer and anchorage length of steel strand in UHPC material is different from that in ordinary concrete; nevertheless, few design standards
are found that how to anchor the transfer and anchoring length of steel strand in UHPC material under normal curing. Through central pull-out test under the different conditions of protective layer thickness and embedded length, the load-slip curves, failure modes, and bond strength of 36
UHPC material specimens under normal curing were studied. The experimental results showed that the ultimate bond stress between UHPC material and steel strand under natural curing conditions is 7.01∼11.68 MPa. When the compressive strength of cube was 157 MPa; the bond strength under natural
curing was smaller than that under thermal curing; when the thickness of the protective layer of steel strand with a diameter of 15.2 mm is greater than 30 mm, it had a little influence on bond strength. The regression analysis of the test results based on the experimental results proves that
the recommended formulas for the design of transfer length and anchorage length of steel strand in UHPC material were in great agreement with the results of published studies.
Effects of Coriander (Coriandrum sativum L.) and Garlic (Allium sativum L.) Essential Oil on the Quality and Fishy Smells During Refrigerated Storage of Restructured Product from Silver Carp (Hypophthalmichthys molitrix) Surimi
Authors: Zhang Dehua , Zhong Yaoguang
Published: January 2020

In order to study the effect of natural plant essential oil on the fishy smell and refrigeration quality of surimi products, silver carp surimi was treated with 2 mL/100 g coriander essential oil, 2 mL/100 g garlic essential oil, 1 mL/100 g coriander essential oil with 1 mL/100 g garlic
essential oil, respectively. The deodorization and preservation effects of coriander and garlic essential oil on frozen surimi products were analyzed by means of electronic nose, sensory evaluation, whiteness, texture, total colonies, volatile base total nitrogen (TVB-N), water holding capacity
and NMR detection. The results showed that coriander and garlic essential oils could effectively reduce the fishy smell of surimi products, significantly inhibit the growth of microorganisms, reduce the oxidation of protein and water loss in surimi, and improve the quality of surimi products
during cold storage. However, 2 mL/100 g coriander essential oil could affect the color of surimi products, the results showed that adding 2 mL/100 g garlic essential oil or 1 mL/100 g coriander essential oil with 1 mL/100 g garlic essential oil could reduce the fishy smell of surimi products,
improve their refrigeration quality and prolong shelf life.
Three-Dimensional Precursor-Derived Synthesis of Co3O4 Towards High Electrochemical Performance
Authors: Zhang Ruili , Yang Yuntao , Yang Ping
Published: January 2020

Three-dimensional (3D) cobalt oxide (Co3O4) flowers with different shapes were prepared by a facile hydrothermal synthesis. The morphology of Co3O4 precursors has adjusted obviously from acicular shapes to acicular-sheet-like flowers and then
to sheet-like flowers by changing reaction temperature and solution concentration. After annealing, as-prepared precursors were converted into 3D flower-like Co3O4 samples and their morphology and sizes were well preserved. The effect of experimental conditions on growth
of Co3O4 precursors was explored and the growth mechanism was proposed. Moreover, the electrochemical properties of various Co3O4 with different shapes were tested. The result of electrochemical investigation indicates that 3D flower-like Co3O4
assembled by sheets exhibited high capacitance and excellent cycling performance.
Correlation Between Genotypes and Allele Frequency of Lymphotoxin-Alpha and Gastric Cancer via Magnetic Separation Dual-Color Fluorescent Genotyping
Authors: Mou Xianbo , Sheng Danni , Bao Zhiyuan , Su Fang , Fan Xiaoxiang , Zhu Yabin , Ye Keyuan , Zhou Qinyi , Zhang Huihui , Xu Chenfeng , Liu Hongna
Published: January 2020

Gastric cancer (GC), as fifth most prevalent cancer in the world, poses a serious threat to people's health, especially in China and some undeveloped countries. If early warning or susceptible population screening for gastric cancer can be achieved, its morbidity and mortality will
undoubtedly be reduced. In this study, mutation of Lymphotoxin-alpha (LTA) gene rs909253 locus of 200 gastric cancer samples and 134 normal samples was completely detected via magnetic separation dual-color fluorescent genotyping method (MSFG), to analyze the correlation between LTA and GC.
Results showed that there were 28 wild types, 48 mutant types, 57 heterozygotes and 1 failed genotyped normal sample. For cases, 194 samples were genotyped successfully, in which 14 samples were wild types, 75 samples were mutant types and other 105 samples were heterozygotes. Further statistical
analysis found that mutant-genotype GG (OR (95%CI), 3.68 (1.80–7.55); P < 0 001) and heterozygous-genotype GA (OR (95%CI), 3.13 (1.50–6.53); P < 0 01) had significant correlation with gastric cancer, as well as allele-G frequency (OR (95%CI), 1.78 (1.27–2.48);
P < 0 001) in subsequent analysis. These results suggest that the LTA gene is closely related to gastric cancer, and its mutation at rs909253 locus could increase the risk for gastric cancer. Detection of LTA gene mutation for screening gastric cancer susceptible population has therefore
significant potential application value in clinic.
Secured Communication for Remote Bio-Medical Monitoring System Using LoRa
Authors: Manoharan Anto Merline , Rathinasabapathy Vimalathithan
Published: January 2020

Recent advancement in IoT technology made profound changes in life style of people. Ease of access of information through smart phones becomes attractive. Everyone like to access datas through their smart phones. IoT enabled application fulfils this requirements. Researchers focusses
on developing the Smart monitoring system using IoT. Since these IoT applications uses existing cellular network for accessing internet. Research says that 50 Billion devices will be willed worldwide in 2020. Providing connectivity to these applications is a challenging task. The existing
4G-LTE network could not support for these much number of devices. Hence an alternative IoT-LoRa network is proposed for these type of application. In this research, a special application in Bio-Medical monitoring System is developed using LoRa Communication. BioMedical Parameters like Weight,
Blood Pressure, Heart beat, Body temperature are measured, encrypted using AES to provide security and transmitted using LoRa to monitoring system through Gateway. The developed system satisfies the need for elderly persons suffering from disabilities and reduces the time for the care taker
to monitor the data. Also the proposed system is highly secured. Our research says, in near future IoT will play vital role in Bio Medical application and Connectivity, Security will be some of the challenging issues in implementation. Without addressing these problems, Bio-Medical Monitoring
System cannot be prognosticated. Finally the potentiality of IoT in Medical field is discussed.
Recent Sensing Technologies for First Line Anti-Tuberculosis Drugs in Pharmaceutical Dosages and Biological Fluids: A Review
Authors: Chokkareddy Rajasekhar , Redhi Gan G.
Published: January 2020

Tuberculosis remains a global problem with a huge burden, estimated at 10.4 million new cases of infection in 2015. First line anti-tuberculosis drugs-based electrochemical sensors are being measured as an important development in the arenas of electroanalysis and are nowadays attracting
the attention of several researchers. Transformation from classic electrochemical sensors which normally accept the complete value of the signal as the output, first line anti-tuberculosis drugs based electrochemical sensors retain dual electrochemical signals and the quantitative extent of
target is based on the ratio of these two signals. Electrochemical methods have integral benefits over other well-established analytical procedures, this review pointing to offer an efficient summary of the newest developments in the voltammetric detection of anti-tuberculosis drugs. Moreover,
the advantages and limits of these approaches are critically discussed and deliberated. The review exposes that in spite of exhausting a variation of chemically fabricated electrodes to isolate the first line anti-tuberculosis drugs, there is still a deficiency of applicability of the voltammetric
techniques to measure these complexes in human body fluids, exclusively in blood plasma and pharmaceutical samples as well.
Do Police Brutality Stories Reduce 911 Calls? Reassessing an Important Criminological Finding
Authors: Zoorob Michael
Published: January 2020

This comment reassesses the prominent claim from Desmond, Papachristos, and Kirk (2016) (DPK) that 911 calls plummeted—and homicides surged—because of a police brutality story in Milwaukee (the Jude story). The results in DPK depend on a substantial outlier 47 weeks after the Jude story, the final week of data. Identical analyses without the outlier final week show that the Jude story had no statistically significant effect on either total 911 calls or violent crime 911 calls. Modeling choices that do not extrapolate from data many weeks after the Jude story—including an event study and “regression discontinuity in time”—also find no evidence that calls declined, a consistent result across predominantly black neighborhoods, predominantly white neighborhoods, and citywide. Finally, plotting the raw data demonstrates stable 911 calls in the weeks around the Jude story. Overall, the existing empirical evidence does not support the theory that publishing brutality stories decreases crime reporting and increases murders.