bluuebunny/crossref_metadata_2025 huggingface dataset:
##Empowerment of BTPN Syariah ## Empowerment of BTPN Syariah customers in the development of Micro, Small and Medium Enterprises in Bogor Regency during the Industry 4.0 era
Authors: Taufik Irwansyah Taufik Irwansyah , Wibowo Agus , Pratama Aditya
Published: May 2024

This research aims to develop the business of BTPN Syariah customers in Bogor district, West Java and to take part in the operation of Small, Micro and Medium Enterprises (MSMEs) in the industrial era 4.0. through a theoretical study approach. This study elaborates several findings from previous researchers as a reference and explores the grounded theory of BTPN Syariah customer development. A qualitative research method with a literature study is carried out to obtain a research reference model in explaining the factors that influence the performance of BTPN Syariah customers in developing their business, capital and strategy. This study also provides suggestions for the development of factors in performance measurement, and variables that affect the performance of MSME entrepreneurs. The results of the study provide recommendations that work skills, digital literacy and economic literacy as a reference in developing MSMEs in the Industrial 4.0 era. MSME training by Bestee friends from BTPN Syariah is a mandatory and routine program to improve customer welfare because it is a successful work program and an indicator of economic growth. But there are very few performance evaluation programs and ongoing development.
Analysis of Factors Affecting the Loyalty of GoPay Customer Through Customer Satisfaction
Authors: Saputra Panca Ardhio , Maulana Alfian , Usman Osly
Published: May 2024

The purpose of this research is to investigate how customer satisfaction for GoPay customers in Jabodetabek is impacted by the interplay of variables such as brand image, loyalty program, and service quality. Partial Least Square - Structural Equation (PLS- SEM) was the data analysis approach employed in this study, and the data were obtained utilizing a purposive sampling strategy. The validity and reliability tests are the analytical methods that are employed. Descriptive analysis factors, outer loading analysis, construct validity and reliability, path coefficient discriminant validity value, r-square value, and significant indirect impact were also employed in this study. The study's findings indicate that while brand image has a favorable but not statistically significant impact on consumer satisfaction, loyalty programs and service quality factors have a considerable positive influence.
The influence of purchasing decisions based on brand image and product quality.
Authors: Cahyani Rany
Published: May 2024

The purpose of this study is to investigate the influence of brand image on consumers. I am decided to purchase AQUA water. The problem studied is the intense competition between bottled water products in Indonesia. This study examines the impact of brand image and product quality on consumers purchasing decisions. The methods used are qualitative and based on literature and library research approaches. Theoretical and historical analyses are used to understand purchasing decisions. Consumer's perception of brand image, product quality, price, advertising, and brand image play an important role in purchasing decisions. This study also describes theoretical measurement elements for future research to describe, explain, and measure purchase decisions based on theoretical research.
Determinants of employees’ turnover intention: A conceptual paper
Authors: AG BUDIN DG KAMISAH
Published: May 2024

Employee turnover is a critical concern for organizations seeking to maintain a stable and productive employee. This conceptual paper investigates the relationship between Human Resource Management (HRM) practices and their influence on turnover intention. The study focuses on specific HRM practices, including Training and Development, Compensation, Performance Appraisal, Job Autonomy, and Career Development. The findings of this study have the potential to provide valuable insights for organizations aiming to reduce turnover rates. It is anticipated that a better understanding of the connections between HRM practices and turnover intention will lead to the development of targeted strategies for talent retention and human resource management. The conclusion drawn from literature support indicates that variables have an influence on turnover intentions. This paper contributes to the existing body of knowledge in HRM and organizational behavior, offering practical implications for HR professionals and managers who seek to enhance employee satisfaction and commitment, ultimately mitigating the costly issue of turnover.
Propolis as an Adjuvant for Colon Cancer Chemotherapy: Exploring its Potential on Apoptosis, Cell Cycle, and PI3K Expression
Authors: Eka Mustika Suryani , Lelo Aznan , Pahlevi Nasution Iqbal , Anjelisa Hasibuan Poppy , Chairani Eyanoer Putri , Ichwan Muhammad , Effendi Rustam , Mustofa
Published: May 2024

يُعتقد أن البروبوليس كعلاج كيميائي مشترك يقلل من شدة الآثار الضارة للعلاج الكيميائي. من المتوقع أن يؤدي الجمع بين البروبوليس والعلاج الكيميائي إلى تحفيز موت الخلايا المبرمج، وإيقاف دورة الخلية، وتقليل تنظيم التعبير عن )-3  PI3K ) وبالتالي تقليل تكاثر خلايا سرطان القولون  WiDr . تم الحصول على خلايا WiDr من مختبر الطفيليات بكلية الطب بجامعة غادجاه مادا في يوجياكارتا بإندونيسيا. يتم جمع ا البروبوليس من قبل النحالين في كابانجاهي، شمال سومطرة. تم اختبار السمية الخلوية لخط خلايا WiDr باستخدام مقايسة تقنية Microculture Tetrazolium (MTT).  
تم تقسيم مجموعة العلاج إلى سبع مجموعات فرعية. تضمنت التجربة معالجة خلايا WiDr بمواد مختلفة: K للمجموعة الضابطة، F لـ 20 ميكروغرام/مل 5-FU، O لـ 5 ميكروغرام/مل أوكساليبلاتين، P لـ 7.5 ميكروغرام/مل  بروبوليس ، PF لمزيج من 7.5 ميكروغرام / مل   بروبوليس و 20 ميكروغرام / مل 5-FU، PO لمزيج من 7.5 ميكروغرام / مل بروبوليس و 5 ميكروغرام / مل أوكساليبلاتين، و FO لمزيج من 5 ميكروغرام / مل أوكساليبلاتين و 20 ميكروغرام / مل 5-FO. تم استخدام قياس التدفق الخلوي للتحقيق في موت الخلايا المبرمج، ودورة الخلية، وملامح PI3K. أدى الجمع بين البروبوليس مع 5-FU أو أوكساليبلاتين إلى تعزيز موت الخلايا المبرمج المبكر والمتأخر. بالإضافة إلى ذلك، لوحظ تثبيط دورة الخلية في المرحلتين G0-G1 وS عندما تم دمج البروبوليس مع 5-FU أو أوكساليبلاتين. تم تثبيط تعبير PI3K بواسطة البروبوليس بالاشتراك مع 5-FU أو أوكساليبلاتين. أظهر البروبوليس، المستخدم كعلاج كيميائي مشترك، فعالية مضادة للسرطان من خلال تحفيز موت الخلايا المبرمج، وتعزيز دورة الخلية، وقمع تعبير PI3K.
Spectrophotometric determination of 4-ethylphenol using cloud point extraction in different water samples
Authors: Mousa Imran Alaa , Ahmed Dhahir Saadiyah , Jassim muklive Ahmed
Published: May 2024

تصف هذه الدراسة تطوير تقنية سهلة ورخيصة ودقيقة وسريعة لقياس 4-اثيل فينول وتنطوي الطريقة الأولية على تحويل -3 نيترو انيلين إلى ملح ديازونيوم ثم التفاعل مع 4 - إثيل فينول في وسط قلوي.المعقد المتكون هو أصفر اللون وله امتصاص عند اعلى طول موجي عند 426 nm. ويتبع قانون بير في مدى خطي قدره 5-12 μg mL-1 مع معامل ارتباط قدره 0.994 وامتصاص مولاري 6.0024x10^3  L.mol-1.cm-1  وتم استُخدِام تقنية نقطة السحابة لقياس كميات قليلة جدا من الفينول باستخدام  TritonX-114 كمفاعلات خافضة للتوتر السطحي، ومن ثم تم القياس باستخدام مقياس طيفي للأشعة فوق البنفسجية. وكانت قيمة معامل الارتباط 0.998، وكان الاامتصاص المولاري هو 1.0476 × 104 L.mol-1.cm-1، وكان المدى الخطي 2-11 μg mL-1 . وحُددت حدود الكشف والتحديد الكمي بأنها 0.42103 و0.140345 μg mL-1، على التوالي. وقد استخدمت الطريقة المقترحة بنجاح لتحديد الفينول في العينات البيئية المختلفة.
WITHDRAWN: Pneumonia in children with complex chronic conditions with tracheostomy: An emerging challenge
Authors: García-Boyano Miguel , Alcalá Francisco José Climent , Alonso Aroa Rodríguez , de Villalta Marta García Fernández , Alonso Ohiane Zubiaur , Retolaza Ignacio Rabanal , Melero Inmaculada Quiles , Calvo Cristina , García Luis Escosa
Published: May 2024

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Enhanced postoperative mobilization and biotracking after colorectal oncological resection (INTENSE) – study protocol for a randomized controlled trial
Authors: Willner Antonie , Kirkgöz Kürsat , Bessick Bernadette E , Klotz Susanne G R , Zapf Antonia , Vojinovic Marina , Auinger Julia , Brodersen Freya , Schneider Tobias , Stremme Jana , Melling Nathaniel , Hackert Thilo , Welsch Thilo
Published: May 2024

Background: Enhanced recovery after surgery (ERAS) is a multimodal perioperative care pathway originally designed to minimize perioperative stress and accelerate postoperative recovery in patients undergoing colorectal surgery. Early mobilization is one central element in the postoperative ERAS setting; however, evidence regarding effective training goals and specific early mobilization protocols is lacking. Therefore, the purpose of this randomized trial is to evaluate an enhanced postoperative mobilization (EPM) programaccompanied by activity and biotrackingafter minimally invasive colorectal surgery for colorectal carcinoma (CRC).
Methods/Design: Patients undergoing minimally invasive resection for CRC will be included in this randomized controlled single-centre trial. Further inclusion criteria areage ³18 years, physical mobility, andsigned informed consent. Patients will be randomized 1:1 for participation in an EPM program within an established ERAS setting during the first five postoperative days (PODs). The patients have two health care staff-assisted physiotherapy sessions a day and wear activity tracker devices to meet daily target step count goals. The control group follows a standard ERAS recommendation. The hierarchical primary endpoints are (i) the time to achieve five predefined discharge criteria (DC) and (ii) the number of steps during PODs 1-5. The sample size (n=50 patients in each group) was calculated based on these DCin a recent test cohort. We hypothesize that more patients would achieve DC by POD 6 after the intervention and would ambulate more. The secondary endpoints includethe GI-2 criterion, activity time, vital signs recorded by activity tracking, mobility level, length of hospital stay, quality of life, 30-day morbidity, and mortality.
Discussion: Individualized EPM programs have rarely been studied in homogeneous minimally invasive colorectal surgery cohorts within a controlled ERAS setting. Today, current available evidence does not support specific EPM protocols to further reduce hospital stays. Biotracking may be an additional motivational factor for enhanced mobilization. This study will provide evidence on the feasibility and effectiveness of a clearly defined EPM beginning on the day of surgery and on patient-reported outcomes.
Trial registration: German Clinical Trials Register. DRKS00033443. Registered on 25 January 2024.
miRNAs in umbilical cord tissue in neonates with different birth weights: a pilot study
Authors: García-Muro Cristina , Toledo-Gotor Cristina , Pasamón-García Sara , Heras María de Pablo-de las , Esteban-Zubero Eduardo , Prado María Yolanda Ruiz del , Domínguez-Garrido Elena
Published: May 2024

Background: Birth weight has been defined as an indicator of perinatal health. miRNAs are small non-coding RNA molecules between 18 and 25 nucleotides that regulate gene expression. Specific miRNAs have been implicated in metabolic pathways that influence fetal growth, so their dysregulation may contribute to birth weight alterations. Our objective was to recover amplifiable miRNAs from umbilical cord tissue and to compare their expression among three groups of patients.
Methods: The study was conducted in a sample 23 patients: 8 small for gestational age (SGA), 10 large for gestational age (LGA) and 5 appropriate for gestational age (AGA) subjects. Umbilical cord tissue samples were obtained immediately after childbirth, stored and then processed. miRNAs expression profile was analyzed in these samples through high-throughput sequencing. The results were assessed through bioinformatic analysis.
Results: We identified significant differences in levels of 6 miRNAs. Compared with AGA and LGA, miR-324-3p was downregulated in SGA, miR-337-3p was upregulated in LGA in comparison to both SGA and AGA, miR-760 was downregulated in LGA compared to SGA and AGA, and miR-4707-3p, miR-548a-3p and miR-6733-5p were upregulated in both SGA and LGA in comparison to AGA. Most of these molecules could be associated with the transforming growth factor-beta signaling pathway.
Conclusions: This exploratory study suggests that the expression of miRNAs in umbilical cord tissue is associated with birth weight. Our findings highlight the downregulation of miRNA-324-3p in SGA newborns, leading us to conclude that its decrease could serve as a marker for low birth weight.
Does a theory-based intervention to improve accountability reduce low-value preoperative tests for patients undergoing low-risk surgery? A pragmatic cluster randomized controlled trial protocol.
Authors: Kirkham Kyle , Patey Andrea M , Mortazhejri Sameh , Ortiz Alfonso , Taljaard Monica , Thavorn Kednapa , Presseau Justin , Bryson Gregory L , Levinson Wendy , Sklar Barbara , Linklater Stefanie , Bhatia Sacha , Grimshaw Jeremy M
Published: May 2024

Background: Low value preoperative tests ordered for patients without any clinical indication undergoing low-risk surgery can lead to further unnecessary investigations or treatments of false-positives. Identified drivers of ordering such low value preoperative tests include uncertainty about who should be responsible for test ordering, perceived inability to cancel tests ordered by fellow physicians and tests being completed before anesthesiologists assess patients. These findings informed a theory-based intervention increasing accountability in the hospital for preoperative test ordering. The objective of the proposed randomised trial is to evaluate whether this intervention reduces unnecessary preoperative tests (ECGs and Chest X-Rays) in patients undergoing low-risk surgery.
Methods: A cluster randomized trial in 22 Ontario hospitals is planned. Eligible hospitals, those falling between the 26th-100th centile for their rate of routine low value preoperative test ordering, will be randomly allocated into the intervention arm (a multicomponent intervention including changing hospital policy, identification of a local champion, delivering an education workshop, and restructuring patient flow and responsibility) or control arm (usual care). A process evaluation will determine whether the intervention is delivered as designed and local champions’ experiences of the delivering the intervention (fidelity). An economic evaluation will determine if the intervention offers good value for money from the perspective of Canada’s health care system. The primary outcome, defined at the level of the hospital, is the proportion of patients receiving one or more low-value preoperative tests within 60 days before surgery. Secondary outcomes are proportions of patients with overnight admission, re-operation in 24 hours, and 30-day all-cause mortality from the date of surgery, in addition to the proportion of patients receiving each of the above preoperative tests individually.
Discussion: Designing interventions to target the de-implementation of low-value care, is critical to improving healthcare for Canadians. Systematically addressing the barriers in a theory-informed manner, and by identifying the most appropriate intervention components for those barriers, increases the likelihood that the intervention will reduce unnecessary care delivered to patients.
Trial registration: ClinicalTrials.gov Identifier: NCT05526495; Registered September 2, 2022
Comparison of two ultrasound-guided brachial plexus block techniques for upper limb orthopaedic procedures in adults
Authors: Yang Xiongtiao , Zeng Jian , Peng Xiaomin , Lei Hongyi , Liu Xianbao , Lu Xiaoqin , Zhong Xiao , Cai Yuna , Chen Hailin
Published: May 2024

This prospective randomized trial was conducted to compare the quality and outcome of perioperative anesthesia between axillary brachial plexus block combined with axillary nerve block (axillary approach group,AX) and supraclavicular brachial plexus block( supraclavicular block group, SU). The primary outcome measure was to compare anesthesia quality evaluation including sensory function, motor function, and subjective feeling scores during skin incision, 30 minutes after skin incision, and at the end of surgery, and postoperative analgesia maintenance time score. Secondary outcomes included the number of patients in whom sufentanil was used, dexmedetomidine (Dex) dose, duration of sensory and motor blocks, number of patients who required remedial analgesia, and procedural complications.The proportion of patients in whom good-to-excellent anesthesia quality was achieved in AX group and SU group were 80% and 76.7%, respectively; anesthesia failure did not occur in both groups. Both procedures met the needs of surgical anesthesia and analgesia. Anesthesia quality and incidence of sufentanil use did not significantly differ between the groups. The incidence of phrenic nerve palsy was significantly higher in the supraclavicular block group (30% vs. zero; P = 0.002).Ultrasound-guided axillary brachial plexus block combined with axillary nerve block can achieve similar anesthesia quality and outcome as supraclavicular brachial plexus block,and found to have similar success rates. Trial registratio: http://www.chictr.org.cn with the registration number of ChiCTR2200057906. Date of first trial of 21/03/2022.
Wetter East Asia and Western United States with projected delayed Southern Ocean warming
Authors: Kim Hanjun , Kang Sarah , Pendergrass Angeline , Lehner Flavio , Shin Yechul , Ceppi Paulo , Yeh Sang-Wook , Song Se-Yong
Published: May 2024

Under global warming, precipitation over East Asia and the Western United States is projected to increase, though associated uncertainties are large. We argue that these precipitation enhancements are partly due to teleconnection from the Southern Ocean, which absorbs anthropogenic heat and gradually releases it with a delay. Based on climate model experiments, we show that the delayed Southern Ocean warming contributes to the tropical Pacific warming, enhancing precipitation during summer in East Asia and winter in the Western United States. An El Niño-like atmospheric teleconnection links the Southern Ocean warming to the Northern Hemisphere regional precipitation increases. Southern Hemisphere low clouds are a key regulator of this teleconnection, partly explaining the projected uncertainty of the regional precipitation. The documented teleconnection has practical implications: even if climate mitigation reduces carbon dioxide levels, the delayed Southern Ocean warming will sustain a wetter East Asia and the Western United States for decades to centuries.
Deep Learning Model Based on CT Images to Predict Ki-67 Expression in Renal Carcinoma
Authors: Shen Dan , Shi Bingye , Ma Tao , Zhou Bin , Gao Chao , Liu Yibo , Cui Zhenyu
Published: May 2024

Objective To establish a preoperative prediction model of Ki-67 expression in renal carcinoma by combining CT images of renal carcinoma with deep learning technology, and to evaluate its effect in clinical application.Methods A retrospective analysis was performed on the CT images and pathological data of 137 patients with renal carcinoma who underwent renal CT plain scan plus enhancement scans and who were diagnosed pathologically from January 2019 to November 2023 at the Affiliated Hospital of Hebei University. All recruited patients were divided into 35 cases with Ki-67 ≥ 10% and 102 cases with Ki-67 < 10% based on Ki-67 expression. Of these, 110 patients were divided into the training group and the test group in a 4:1 ratio, and the remaining 27 cases were used as clinical validation group. Based on the Mobilenetv3-large model, prediction models incorporating plain scan, arterial, venous and excretion phases were constructed using the training set data. The predictive performance of the models, including accuracy, accuracy, sensitivity, specificity, F1 score, and AUC values, were assessed by inputting CT images of the test group. The best-performing model was applied to the clinical validation group to compare the predicted results with the actual results of pathology; the accuracy, sensitivity, specificity and Kappa coefficient of the model were calculated to assess its clinical efficacy.Results The Mobilenetv3-large model in the venous phase showed the best performance in terms of accuracy, sensitivity and F1 score, as well as relatively high precision and AUC value, indicating good robustness. In the clinical validation group, the model predicted Ki-67 expression with an accuracy of 0.814, sensitivity and specificity of 0.889 and 0.667 at low and high levels, respectively, and a Kappa coefficient of 0.57.Conclusion The Mobilenetv3-large model based on venous-phase CT images is potentially clinically valuable as it can effectively predict Ki-67 expression and provide accurate, efficient, and noninvasive support for the development of personalized treatment plans.
Synergistic plasticization and anti-aging effect of hyperbranched poly(1,4-butanediol citrate)/glycerol on corn starch
Authors: Zhang Kang , Jin Dongliang , Ouyang Haishun , He Yixuan , Cao Peiqin , Wang Rongrong , Tang Kewen , Wei Yujun , Cheng Fei , Zhu Puxin
Published: May 2024

Thermoplastic starch plasticized with glycerol is very sensitive to humidity and aging. In this study, hyperbranched poly(1,4-butanediol citrate) is prepared via a one-step method, and is mixed with glycerol as the co-plasticizer of starch to prepare thermoplastic starch films. The structure of hyperbranched poly(1,4-butanediol citrate) is studied by performing Fourier-transform infrared spectroscopy and 1H nuclear magnetic resonance analyses. The interaction between starch and co-plasticizer, and crystallinity, mechanical properties, anti-aging properties, thermal stability, transmittance, and moisture absorption of thermoplastic starch films are studied. The results illustrate that poly(1,4-butanediol citrate)/glycerol has a synergistic effect on the plasticization, anti-aging properties, transmittance, and moisture adsorption properties of thermoplastic starch films. The thermoplastic starch film with a poly(1,4-butanediol citrate)/glycerol weight ratio of 2:28 has the maximum elongation at break, the highest transmittance, the optimal ability to inhibit the long-term retrogradation of starch and the lowest moisture content at the relative humidity of 68%. Elongation at break of thermoplastic starch film with poly(1, 4-butanediol citrate)/glycerol at 2/28 and stored for 3 and 30 days are (101.1 ± 14.0)% and (91.7 ± 2.7)%, respectively, which are 1.8 and 4.4 times that of the thermoplastic starch film with only glycerol, respectively. These phenomenon not only depend on the interaction between starch and co-plasticizer, but also may be related to the compatibility between starch and co-plasticizer. Thus, the poly(1,4-butanediol citrate)/glycerol combination has potential applications in the processing of thermoplastic starch. 1 Introduction
Risk factors for pneumonia after radical gastrectomy for gastric cancer: A systematic review and meta-analysis
Authors: Fan Siyue , Jiang Hongzhan , Xu Qiuqin , Shen Jiali , Lin Huihui , Yang Liping , Yu Doudou , Zheng Nengtong , Chen Lijuan
Published: May 2024

Objective
The objective is to systematically gather the relevant research to determine and quantify the risk factors for pneumonia after a radical gastrectomy for gastric cancer.
Methods
The reporting procedures of this meta-analysis conformed to the PRISMA 2020. Chinese Wan Fang data, Chinese National Knowledge Infrastructure (CNKI), Chinese Periodical Full-text Database (VIP), Embase, Scopus, CINAHL, Ovid MEDLINE, PubMed, Web of Science, Cochrane Library, Embase, and Scopus from the time of inception to January 20, 2024, data were systematically searched for cohort or case-control studies that reported particular risk factors for pneumonia after radical gastrectomy for gastric cancer. The quality was assessed using the Newcastle-Ottawa Scale after the chosen studies had been screened and the data retrieved. Rev Man 5.4 was the program used to perform the meta-analysis.
Results
Our study included data from 27,840 individuals across 27 trials. Fifteen risk factors were statistically significant, according to pooled analyses. Several factors were identified to be strong risk factors (OR: 2.21–4.72), including smoking history, prolonged postoperative nasogastric tube retention, intraoperative bleeding ≥ 200 ml, diabetes mellitus, male gender, total gastrectomy, COPD, impaired respiratory function, D2 lymphadenectomy, perioperative blood transfusion, and hypertension. Moderate risk factors included excessive surgery duration, advanced age, nutritional status, and history of pulmonary disease (OR: 1.51–1.91).
Conclusions
The study identified 15 independent risk factors significantly associated with pneumonia after radical gastrectomy for gastric cancer. These results offer evidence-based procedures for putting into practice successful preventive interventions.
Preliminary Control-Oriented Modeling of the ITER Steering Mirror Assembly and local control system in the Electron Cyclotron Heating & Current Drive actuator
Authors: Grapow Gabriele , Ravensbergen Timotheus , D’Onorio Matteo , Pesamosca Federico , Vu Annatrang , Carannante Giuseppe
Published: May 2024

The ITER Electron Cyclotron Heating and Current Drive (ECH) plays a pivotal role in heating and controlling fusion plasmas, with the Steering Mirrors being a crucial component of this actuator. A representative model of the ECH is compulsory in the development and validation of the Plasma Control System (PCS). This manuscript aims to propose a Control-Oriented model of the Steering Mirrors based on the design tested at the Swiss Plasma Centre. In this design a steering mirror rotates on some frictionless flexure pivots due to the action of a set of externally pressurized bellows acting against pre-compressed springs. This system is referred to as the Steering Mirror Assembly (SMA). The adherence of the model is tested by comparing the simulations with the experimental results, while considering ITER’s most recent requirements. Performances, generally increased in terms of accuracy, are in line with the prototype’s results.
Developing a comprehensive abortion prevention program for couples based on I-change model: Study protocol for a mixed method research
Authors: Dolatabadi Zari , Moridi Maryam , Farnam Farnaz , Damghanian Maryam
Published: May 2024

Background
​ In countries where abortion laws are stringent, induced abortions are prevalent. The limited availability of abortion services within these regions amplifies the likelihood of maternal complications and mortality. Induced abortions represent a significant public health concern in Iran and are characterized by a multitude of intricate factors that remain largely unexplored. Gaps in knowledge persist pertaining to the influences driving induced abortion within the Iranian context. To adequately address the issue of induced abortion, it is imperative to discern the determinants that shape the decision-making process. The primary objective of this study was to design an intervention program focused on mitigating the occurrence of induced abortion within couples, with an emphasis on identifying the key factors that contribute to this phenomenon.
Methods
This study comprises three phases. In the first phase, a qualitative approach based on the I-change model will be employed to identify the factors influencing induced abortion. The second phase involves a systematic review to identify the determinants of induced abortion and strategies to prevent induced abortion. In the third phase, the outcomes of the qualitative approach and systematic review will be shared with experts and specialists using the Delphi method to categorize and prioritize strategies. Subsequently, based on the final consensus, a comprehensive program will be developed to prevent induced abortion.
Discussion
This study introduces an I-change model-based program for the prevention of induced abortion. The prevention of induced abortion holds great significance in mitigating maternal morbidity and mortality, curtailing healthcare expenses, and fostering population growth rates. The research findings will be disseminated via reputable peer-reviewed journals and communicated to the academic and medical communities. This dissemination aims to provide valuable insights that can contribute to the advancement of induced abortion and abortion prevention programs.
Increasing the trial size of the Forced Choice Test by expanding the number of answer alternatives
Authors: Otsuka Takuro , Orthey Robin
Published: May 2024

The Forced Choice Test (FCT) is considered as a memory detection test that can be used in criminal investigations. However, one problem in its application is that it is difficult to secure a sufficient number of questions that can be formulated based on evidence. In this study, we proposed a modified version of the FCT as a memory detection test. Modified FCT uses fewer pieces of criminal information than typical FCT by expanding the number of answer alternatives for each question and creating multiple unique pairs of answer alternatives for a single question. We subjected participants to a mock crime followed by a typical FCT or our novel FCT, which relies on less information. We demonstrate that both FCT types have similar detection accuracies. Hence, the modified FCT may improve the applicability of FCT as a memory detection tool because fewer evidence is needed. We discussed the characteristics of the modified FCT from the viewpoint of the participants’ strategy and detection efficiency.
Molecular Dynamics Study on Anti-fouling Properties of Polybenzimidazole Membrane
Authors: Lv Zhiwei , jia shujuan , wang xuan , li simin
Published: May 2024

Polybenzimidazole (PBI) is a kind of aromatic polymer with high heat resistance and mechanical strength. In this study, polybenzimidazole (PBI) and its two derivatives PBIO, PBIO2) were constructed by N-substitution reaction grafted hydrophilic side chains (Original, 1-Bromo-3-methoxypropane and 1-Bromo-2-(2-methoxyethoxy) ethane), and the structure and protein resistance of the three polymer membranes were studied by molecular dynamics. The results of hydrophilic group grafted PBI were confirmed by calculation, can improve the anti-fouling ability of the membrane surface. Therefore, the development of PBI films with excellent hydrophilic properties and good anti-fouling performance is of great significance.
Polyanionic Receptors for Carboxylates in Water
Authors: Davis Anthony , Ren Xudong , Flint Alister , Austin Daniel
Published: May 2024

Receptors for carboxylate anions have many possible biomedical applications, including mimicry of the vancomycin group of antibiotics. However, binding carboxylates in water, the biological solvent, is highly challenging due to the hydrophilicity of these polar anions. Here we report, for the first time, the recognition of simple carboxylates such as acetate and formate in water by synthetic receptors with charge-neutral binding sites. The receptors are solubilised by polyanionic side-chains which, remarkably, do not preclude anion binding. The tricyclic structures feature two identical binding sites linked by polyaromatic bridges, capable of folding into closed, twisted conformations. This folding is hypothesised to preorganise the structures for anion recognition, mimicking the process which generates many protein binding sites. The architecture is suitable for elaboration into enclosed structures with potential for selective recognition of biologically relevant carboxylates.
Shallow Storage Dewatering for End-of-phase open pit mining Operations using Blastholes
Authors: Valdés-Pineda Rodrigo , Dowling Jeremy , Haas Peter , Feehan Tom , Noguera Camy
Published: May 2024

Mining operations often face challenges in managing water levels during the concluding phases of open-pit extraction and pit floor deepening, where efficient shallow dewatering is critical for continued operations. This technical article explores and discusses a successful engineering application of blastholes for shallow dewatering, presenting a novel approach that optimizes water removal and enhances operational mining and safety. Through the drilling and construction of blasthole wells, this method has demonstrated significant benefits and results, providing a strategic solution for (1) operational continuity of mining operations during the concluding phases of open-pit extraction; (2) achieving targeted dewatering objectives to meet production goals; and (3) providing safer working conditions by minimizing the risks associated with excess water accumulation that can pose hazards to equipment and personnel. Furthermore, it addresses the risk of losing the final and most economically important benches of a phase if traditional dewatering methods have fallen behind during the phase development. The conclusions highlight the effectiveness and adaptability of blasthole wells for rapid removal of shallow water storage to accomplish operational, safety, and efficiency benefits to mining operations, offering a valuable contribution to the progress of end-of-phase open pit mining.
Deep Imputation for Skeleton Data (DISK) for Behavioral Science
Authors: Rose France , Michaluk Monika , Blindauer Timon , Ignatowska-Jankowska Bogna , O'Shaughnessy Liam , Stephens Greg , Pereira Talmo , Uusisaari Marylka , Bozek Katarzyna
Published: May 2024

Pose estimation methods and motion capture systems have opened doors to quantitative measurements of animal kinematics. However, these methods are not perfect and contain missing data. Our method, Deep Imputation for Skeleton data (DISK), leverages deep learning algorithms to learn dependencies between keypoints and their dynamics to impute missing tracking data. We developed an unsupervised training scheme, which does not rely on manual annotations, and tested several neural network architectures for the imputation task. We found that transformer outperforms other architectures including graph convolutional networks that were developed specifically for skeleton-based action recognition. We demonstrate the usability and performance of our imputation method on seven different animal skeletons including two multi-animal set-ups. With an optional estimated imputation error, DISK enables behavior scientists to assess the reliability of the imputed data. The imputed recordings allow to detect more episodes of motion, such as steps, and to obtain more statistically robust results when comparing these episodes between experimental conditions.
While animal behavior experiments are expensive and complex, tracking errors make sometimes large portions of the experimental data unusable. DISK allows for filling in the missing information and for taking full advantage of the rich behavioral data. This stand-alone imputation package, freely available at https://github.com/bozeklab/DISK.git, is applicable to results of any tracking method (marker-based or markerless) and allows for any type of downstream analysis.
A Correlational Study of Emotional Deprivation And Bullying Victimization In Adolescence With Single Parent
Authors: Arshad Laiba
Published: May 2024

The study was conducted to investigate the relationship between emotional deprivation and bullying victimization in adolescents with single parents. It is hypothesized that there is a relationship between emotional deprivation and bullying victimization. Moreover the study investigate the impact of emotional deprivation and bullying victimization on adolescents with single parent. For collecting data two scale was used namely young person schemas (YSQ: Jeffery,2008) and adolescents peer relationship scale (APRS: Parada,2000). Both scales are 6- point Likert scale having 5 and 18 items respectively. Purposive sampling strategy was used to collect data from 150 students of different private and public educational institutes of Gujranwala, age range of 13 to 18 years. SPSS version 27 was used to run analysis.A positive relationship was established between bullying victimization and the emotional deprivation. Such gender differences were observed, with the males showing greater magnitudes. Regression analysis suggests that bullying victimization predicts the emotional Deprivation. Pearson moment correlation, independent sample t-test and regression analysis. Reliability analysis showed high alpha values of both variables. The Pearson product-moment correlation analysis revealed that Emotional Deprivation and Bullying Victimization are highly positive correlate. Regression analysis showed that emotional deprivation does promote bullying victimization.
An S-box multi-objective optimization algorithm based on composite chaos and rolling Boolean
Authors: Cheng Liming , Tong Xiaojun , Wang Zhu , Zhang Miao
Published: May 2024

As a critical component in cryptographic algorithms, the S-box plays a crucial role in modern cryptography. In this paper, we first study the properties of traditional chaotic systems, design a one-dimensional chaotic system with an extensive parameter range and excellent chaotic properties, and design an initial chaotic S-box based on the system. Secondly, we create a Boolean function nonlinearity boosting algorithm based on the proposed Boolean function nonlinearity boosting theorem and a rolling Boolean S-box nonlinearity boosting theorem based on the proposed S-box nonlinearity boosting theorem. S-box nonlinearity boosting algorithm. In addition, for the constructed high nonlinear S-box, the other performances of the S-box are further optimized by a multi-objective optimization annealing algorithm. The best S-box obtained is analyzed for the performance of nonlinearity, strict avalanche, linear approximation probability, differential uniformity, and bit-independence criterion. We receive a high-performance S-box with a nonlinearity of 114.75. Finally, a high-performance S-box with a nonlinearity of 114.75 is designed. Image encryption that only relies on the S-box, and through the tests of the histogram, adjacent-pixels correlation, and information entropy, the results show that the generated high-performance S-box has a complex substitution effect, which is sufficient to meet the nonlinear design requirements of the packet encryption algorithm.
Screening and mechanism study on SARS-CoV-2 Mpro inhibitory of peptides from Spirulina platensis
Authors: Zeng Qiao-Hui , Yao Zhi-En , Zhou Xian-Min , Qi Ping , Zeng Xin-An
Published: May 2024

In this study, four kinds of Spirulina platensis ( S. platensis) peptides were obtained by enzymolysis of protein after different pretreatment to S. platensis powders. The novel coronavirus main protease (SARS-CoV-2 main protease, Mpro) was successfully prepared by heterologous expression in E. coli and its activity was detected. After identification of S. platensis peptides sequences, highly active peptides were synthesized and their inhibition effects on Mpro was verified. Subsequnently, the mechanism of action between them were analyzed by computer simulations. Results showed that the extraction rate of the protein from S. platensis was 96.11%, the activity of Mpro was 845.90 U mg-1, the peptide MQGPNY could inhibit the activity of Mpro with the inhibition rate of 20.21%±3.8% at the concentration of 2 mM. Fuerthermore, results from computer Simulation showed that the peptide MQGPNY forms four pairs of hydrogen bonds with Mpro, which are Gln189, Ser46, Thr26 and Glu166. In addition, there were nine free residues involved in hydrophobic contacts, which were His164, His41, Thr24, Met49, Thr45, Thr25, Gly143, Asn142, and Cys145 and Met165. This study developed natural peptides from S. platensis, which could inhibited the activity of Mpro. Besides, the mechanism of the peptide MQGPN acting on Mpro was revealed by the method of computer Simulation. The foundings could provide theoretical support for the use of protein and its hydrolysates from S. platensis in functional food and supplement formulations in the post-epidemic era.
Improvement of 3D printing performance of whey protein isolate emulsion gels by regulating rheological properties: Effect of polysaccharides incorporation
Authors: Li Ming , Feng Lei , Dai Zhuqing , Li Dajing , Zhang Zhongyuan , Zhou Cunshan , Yu Dongxing
Published: May 2024

The interaction of polysaccharide and protein can improve the emulsification and gelation properties of emulsion gel, which is a good substrate for 3D printing food. Whey protein isolate (WPI) emulsion gels added with guar gum (GG), locust bean gum (LBG), xanthan gum (XG) and gum arabic (GA) were investigated for 3D printing β-carotene-rich food. The effect of different polysaccharide concentrations on the rheological properties, 3D printing performances and moisture distribution characteristics of emulsion gels were analyzed. The results showed that WPI emulsion gels with addition of polysaccharides had shear-thinning behavior and exhibited elastic property. WPI emulsion gels added with higher concentrations of polysaccharides had the higher transient elasticity and viscosity, which exhibited the higher deformation resistance. Water holding capacity and gel strength of WPI emulsion gels increased with the increase of polysaccharide concentration, and WPI emulsion gels added with GG and LBG showed the larger gel strength values. Water trapped in the gel network dominated in WPI emulsion gels, T21, T22 and T23 values decreased with the increases of polysaccharide concentration. The results showed that 7% of GG, LBG and GA could improve the 3D printing performance and significantly increased the printing accuracy and stability of WPI emulsion gels. This study could help to develop 3D printed functional foods.
Germicidal Activity on Leather Fabrics by Aluminium Oxide Nanoparticles and Their Characterization
Authors: Ganesan Nirmala
Published: May 2024

Background
Au NPs, or metal aluminium oxide nanoparticles, were created on leather textiles on-site. Several instrumental methods were employed, such as FTIR, HR-TEM, XRD, and UV-Vis spectrophotometry. Using disc diffusion against bacterial strains of Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumonia, the antibacterial activity of aluminium oxide nanoparticles was investigated.
Objective
This work should create new opportunities for innovation in the leather industries since it provides a first step toward the bio-functionalization and colouring of different leather fabrics using green technologies.
Methods
X-ray diffraction (XRD), Fourier transform infrared spectroscopy, and characterization: Scanning electron microscope (SEM)Aluminium oxide nanoparticles' biological activity and the antibacterial properties of leather materials using al2O3 nanoparticles
Results
Because of its potent antibacterial properties, aluminium oxide nanoparticle production is a rapidly developing technique in nanotechnology. X-ray diffraction analysis, Fourier transform infrared spectroscopy, and a UV-visible spectrophotometer were used to characterize the produced aluminium oxide nanoparticle. The FTIR and XRD measurements demonstrated good peak results because aluminium oxide has good structural characteristics. Using disc diffusion against bacterial strains of Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumonia, the antibacterial activity of aluminium oxide nanoparticles was investigated. Aeruginosa exhibited a higher activity of 13mm in comparison to the other strains, although all three species demonstrated good activity for the Al2O3 included leather. SEM was used to further analyse the leather textiles that contained Al2O3. The amount of Al2O3 NPs that have been deposited on leather material has produced great results for leather fabrics that have been dipped.
Conclusion
Sol-gel synthesis of alumina nanoparticles has been achieved with success. Al2O3 nanoparticles' antibacterial activity against three strains was demonstrated to be effective. The multifunctional qualities of leather were enhanced by applying her synthesized Al2O3 NPs to leather textiles. An immersion method was used to deposit Al2O3 on leather textiles. Adsorbed on the leather fabric's surface, the nanoparticles were uniformly bonded to the coated leather fabric's surface.
Outcomes of a Pilot Outreach Program to Support Point-of-Care Screening in Individuals with Diabetes who are Experiencing Homelessness in Alberta, Canada
Authors: Scott Sara , Grewal Eshleen K. , Campbell David J.T.
Published: May 2024

Background
Accessing diabetes care, including screening for microvascular complications, requires effort and time. Social complexity, such as homelessness, often forces individuals to prioritize securing shelter and safety over medical appointments, particularly for the prevention of long-term complications.
Methods
We designed and conducted a non-randomized pilot study of a point-of-care screening program with expedited referral pathways within two inner-city community sites in Calgary, Canada which are accessed by individuals experiencing homelessness. Adults experiencing homelessness and diabetes were recruited through the host sites and invited to two separate visits. Microvascular screening (retinal fundoscopic images, albumin-to-creatinine ratio testing, and foot neurovascular assessment), glycemic monitoring, and footcare were performed at the first visit. The nurse shared the screening results and helped facilitate follow-up at the second visit. We compared the screening completion rates after visiting our program to historical screening over the past two years, based on chart review and patient reports. We also assessed the domains of reach and implementation as per the RE-AIM framework.
Results
Compared to the previous two years, participants (n = 40) experienced a 2.9-fold increase in peripheral neuropathy screening; a 1.7-fold increase in diabetic retinopathy screening; and a 90% increase in diabetic nephropathy screening. We also documented a 73% increase in glycemic monitoring. Most participants (83%) attended both clinic visits. Despite this unique model, challenges facilitating follow-up specialist visits remain, with fewer than half of referred patients attending follow-up visits. The cost of the pilot ($846/visit) illustrates this model requires modifications to yield optimal value.
Conclusions
Our findings show the SAFER model significantly increased screening rates for our sample, however, innovative approaches to healthcare are still needed for this population. Potential value-based adjustments include partnering with more community sites already servicing this population and expanding the scope of the care offered and the target population.
Design and performance analysis of a robot flexible connection device based on quasi-zero-stiffness mechanism
Authors: Ju Jinyong , Ji Xuyang , Liu Yufei
Published: May 2024

For suppressing the vibration excitation transmission from the robot to the elastic component during robotic handling, a new type of quasi-zero-stiffness flexible connection device (QZSCD) is designed. By introducing the tilt linkage on the basis of traditional quasi-zero-stiffness isolator with three oblique springs, the QZSCD can actively adapt to varying load conditions. According to the static equilibrium relationship, the conditions that the QZSCD has zero-stiffness at the equilibrium position are obtained. Then, the optimal structure parameters of the QZSCD are determined based on maximizing the system quasi-zero-stiffness interval. And the quantitative relationship between the angle of the tilt linkage and the load mass is investigated. Furthermore, a unified dynamic equation for the QZSCD under varying load conditions is established. The influences of the structural parameters, the tilt linkage angle, and the load mass on the vibration response and displacement transmission characteristics of the QZSCD are analyzed. Simulation and experimental results indicate that by actively adjusting the tilt linkage angle, the QZSCD can ensure good vibration transmission suppression performance under varying load conditions during the robotic handling of the elastic component.