bluuebunny/crossref_metadata_2025 huggingface dataset:
CREATING AND TRAINING OF PAKCOY HYDROPONIC CULTIVATION IN ORDER TO IMPROVE THE WELFARE OF USTADZ WIVES PONDOK PESANTREN RIYADHUSSHOLIHIIN-CIMANUK-PANDEGLANG
Authors: WAHYUNI Putri Dwi , HANDAYANI Yenny Dwi , MARIANTO Marianto
Published: December 2023

The hydrogenic farming method is a plant cultivation method that combines hydroponic and organic (no chemicals) farming systems. In this hydrogenic method, the natural fertilizer comes from fish waste that flows together with the flow of pond water through pipe installations. Vegetables produced from hydroponic technology are considered healthier and more environmentally friendly because they utilize a variety of organic fertilizers. Pondok Pesantren Riyadhussholihiin is an Islamic educational institution located in Rocek village, Cimanuk sub-district, Pandeglang district, Banten which is engaged in formal and non-formal Islamic education. At the boarding school, there are the wives of the ustadz who help meet the daily consumption needs of the boarding school residents so this training activity can be useful in improving the welfare of the ustadz's wives through entrepreneurial activities and improving consumption patterns through hydroponic vegetables, especially pakcoy. The results of the activities that have been carried out that the target audience is very enthusiastic and gives a positive response to the community service activities that have been carried out. This can be seen from the results of the questionnaire that has been given which states that 51.26% strongly agree on the activities of making and training in the cultivation of hydroponics pakcoy vegetable plants.
BUILDING AWARENESS OF THE IMPORTANCE OF REPRODUCTIVE HEALTH AND HEALTHY LIVING SKILLS THROUGH THE PLANNING GENERATION PROGRAM
Authors: YULIAWATI Elly
Published: December 2023

The large number of teenagers who have free time from study activities, sports, tutoring and little time outdoors as well as minimal parental supervision has been pointed out as one of the opportunities for an increase in child marriage during the Covid-19 pandemic. In addition, knowledge about reproductive health and sexuality among teenagers is still relatively low. Teenagers need to prepare themselves to face the challenges of life today and life in the future. The aim of this activity is to equip students at SMKN 49 North Jakarta about reproductive health and healthy living skills. The results of the activity showed an increase in participants' knowledge and understanding of the Planned Generation Program (GenRe) as a program that facilitates teenagers to behave healthily, avoiding the risks of the KRR Triad (sexuality, HIV/AIDS, drugs). As many as 83.3% already understand the definition and concept of TRIAD KRR. Participants also agreed that the problems that occurred were due to a lack of education about reproductive health, as well as a lack of education regarding the negative impacts of ignorance about reproductive health. Participants felt that this activity motivated them and was useful for determining goals after graduating from school, future choices that they would pursue and pursue. So that with this knowledge, teenagers have the provisions to protect themselves from negative things, know how to implement healthy living and can build better life plans.
RUSUN TAMANSARI DAN DAMPAK SOSIAL: UPAYA REKAYASA SOSIAL MENGHILANGKAN KAMPUNG KUMUH
Authors: Achmad Willya
Published: December 2023

Permukiman kumuh diartikan sebagai tempat dimana itu tidak layak untuk ditinggali oleh seseorang dengan segala kekurangannya. Pada dasarnya rumah atau hunian merupakan salah satu kebutuhan dasar manusia yang berfungsi untuk mendukung terselenggaranya aktivitas kehidupan manusia seharihari. Salah satu permasalahan utama yang dihadapi kota besar adalah keterbatasan lahan dalam menghadapi tingginya kebutuhan perumahan bagi penduduk perkotaan. Penelitian ini menggunakan metode studi kasus dengan pendekatan kualitatif, adapun hasil dan kesimpulannya menjelaskan bahwa, pertumbuhan dan perkembangan suatu kota membawa pengaruh terhadap struktur maupun kegiatan yang ada didalamnya. Terpusatnya beragam aktivitas pada kota mempengaruhi laju urbanisasi menuju kota tersebut, yang mana proses ini dapat memberikan dampak positif maupun negatif serta menyebabkan pesatnya pertumbuhan permukiman kumuh diberbagai pelosok daerah, tidak terkecuali di wilayah Kota Bandung. Berdasarkan hasil kajian yang ada, Pemerintah Kota Bandung telah menetapkan lokasi permukiman kumuh melalui SK Walikota Nomor 648/Kep.286-distarcip/2015 tentang Penetapan Lokasi Lingkungan Perumahan dan Permukiman kumuh di Kota Bandung. Pemerintah Kota Bandung telah melaksanakan program-program terkait dalam usaha perbaikan permukiman kumuh, diantaranya adalah program peningkatan sarana dan prasarana permukiman, penataan bangunan dan pembangunan rumah susun (Rumah deret). Dengan ketersediaan sarana dan prasarana yang lengkap serta transportasi yang mudah dijangkau dan terintegrasi, diharapkan penyediaan rusun Tamansari di Kota Bandung dapat menghemat pengeluaran sehari-hari, sehingga masyarakat akan mempunyai kesempatan menabung untuk mampu mendapatkan hunian sendiri secara legal. Peningkatan kualitas hunian melalui pembangunan rumah susun juga diharapkan dapat menekan luasan perkembangan kawasan kumuh terutama di beberapa kota-kota besar di Indonesia.
UPAYA MENINGKATKAN KOMPETENSI GURU DALAM PENGGUNAAN IT SEBAGAI MEDIA MENGAJAR MELALUI WORKSHOP DI SDS KATOLIK SANTO PAULUS TAHUN PELAJARAN 2020/2021
Authors: Parjiyem Parjiyem
Published: December 2023

Realita yang terjadi di SDS Katolik Santo Paulus adalah kompetensi guru dalam penggunaan IT sebagai media mengajar masih rendah. Hal ini di tunjukkan dengan beberapa data di lapangan yaitu guru belum menguasai dasar-dasar TIK (ICT Literacy), guru belum mendalami pengetahuan (akuisisi dan rekayasa pengetahuannya) melalui TIK, guru belum mempunyai kemampuan untuk mengkreasi pengetahuan dengan TIK dan guru belum bisa berbagi ilmu dengan menggunakan TIK atau tentang TIK, baik kepada siswa maupun guru lainnya. Oleh karenanya peneliti di sini hendak meningkatkan kompetensi guru dalam penggunaan IT sebagai media mengajar melalui Workshop. Teknik pengumpulan data yang akan digunakan dalam penelitian ini adalah observasi, dokumentasi dan wawancara. Hasil siklus I pertemuan ke 1, skor penilaian yang di peroleh masing-masing guru hasilnya adalah sekitar 18-20 artinya kompetensi guru dalam penggunaan IT sebagai media mengajar sedang. Hasil siklus I pertemuan ke 2, skor penilaian yang di peroleh masing-masing guru hasilnya adalah 30-32 artinya kompetensi guru dalam penggunaan IT sebagai media mengajar sedang. Hasil penelitian siklus II pertemuan ke 1, skor penilaian yang di peroleh masing-masing guru hasilnya adalah 35-40 artinya kompetensi guru dalam penggunaan IT sebagai media mengajar tinggi. Hasil siklus II pertemuan ke 1, skor penilaian yang di peroleh masing-masing guru hasilnya adalah 40-45 artinya kompetensi guru dalam penggunaan IT sebagai media mengajar tinggi. Sedangkan di lihat dari hasil observasi siklus II pertemuan ke 1 skor penilaian yang di peroleh masing-masing guru hasilnya adalah sekitar 50-55 artinya keberhasilan Workshop dalam meningkatkan kompetensi guru dalam penggunaan IT sebagai media mengajar baik.
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING DALAM UPAYA MENINGKATKAN MOTIVASI BELAJAR SISWA PADA PELAJARAN MATEMATIKA MATERI PEMBAGIAN SUSUN KELAS VI SDN 1 SELAT DALAM TAHUN 2020/2021
Authors: Rubikah Sukmowati
Published: December 2023

Berdasarkan hasil observasi guru kelas di hasilkan bahwa masih banyak siswa yang belum bisa mengerjakan soal pembagian bersusun. Selain itu, dalam pembelajaran pembagian bersusun guru belum pernah mengadakan diagnosis kesulitan belajar yang dialami siswa secara mendalam. Siswa dikatakan mengalami kesulitan belajar jika mendapatkan nilai rendah dalam penguasaan materi pembagian bersusun.Oleh karenanya guru kelas yang disini merupakan peneliti hendak meningkatkan motivasi belajar siswa pada pelajaran matematika materi pembagian susun (porogapit) melalui model pembelajaran problem based learning. Penelitian ini merupakan penelitian tindakan kelas. Penelitian ini akan dilaksanakan di SDN 1 Selat. Metode pengumpulan data dalam penelitian ini adalah teknik observasi, wawancacara, Tes dan dokumentasi. Adapun hasil observasi siklus I di peroleh skor 181 artinya Motivasi belajar siswa pada pelajaran matematika materi pembagian susun (porogapit) baik, dan jumlah siswa yang tuntas belajar adalah 22 sedangkan Rata-rata kelas siklus I adalah 75,79. Hasil observasi motivasi belajar siswa pada siklus II menyebutkan bahwa ketertarikan siswa untuk mempelajari materi pembelajaran meningkat dibandingkan siklus sebelumnya sehingga dapat dikatakan siswa semakin terpemahaman dengan penggunaan model pembelajaran problem based learning oleh siswa. Adapun hasil observasi siklus II di peroleh skor 220 artinya Motivasi belajar siswa pada pelajaran matematika materi pembagian susun (porogapit) sangat baik, dan jumlah siswa yang tuntas belajar adalah 28 sedangkan Rata-rata kelas siklus II adalah 80,48, artinya penggunaan Model pembelajaran problem based learning mampu meningkatkan motivasi belajar siswa pada pelajaran matematika materi pembagian susun (porogapit).
Ryczałt od dochodów spółek – stan obecny i postulaty de lege ferenda
Authors: Jamroży Marcin , Łożykowski Aleksander , Sarnowski Jan
Published: December 2023

Przedmiotem artykułu jest zidentyfikowanie deficytów funkcjonowania podatku dochodowego od osób prawnych i wypracowanie postulatów de lege ferenda. W swoich rozważaniach autorzy odniosą się zarówno do klasycznego systemu opodatkowania dochodów, jak i do ryczałtu od dochodów spółek. Ryczałt od dochodów spółek stanowi alternatywny mechanizm opodatkowania, powiązany z momentem wypłaty zysków. W artykule autorzy diagnozują deficyty w wybranych obszarach opodatkowania spółek (obecny stan rzeczy) oraz przedstawiają rekomendacje zmian.
Участь засобів масової інформації у запобіганні злочинності в умовах воєнного стану в Україні (на прикладі міста Ірпінь Київської області)
Authors: Бодунова O. , Яцик т , Лугіна Н.
Published: December 2023

У науковій статті розглядаються основні принципи взаємодії ЗМІ з правоохо­ронними органами в Україні в умовах воєнного стану. Зазначається, що з 24 лютого 2022 року російські окупанти ведуть активну інформаційну війну, крім активних бойових дій, розстрілів мирних жителів, агресивного руйнування будинків та розкрадання майна. Вона проявляється у використанні фейкових профілів у соціальних мережах для отримання інформації про дислокацію Збройних сил України, терито­ріальну оборону та дезінформації цивільного населення, надання українцям неправдивої інформації з метою їх повернення у зону активних бойових дій. Відмічено, що окупантами була проведена активна інформаційна атака на національні ЗМІ з метою припинення поширення інформації про російську агресію та вбивства мирних жителів.

Зазначено, що під взаємодією правоохоронних органів і ЗМІ варто розуміти своєрідні відносини між пресслужбами правоохоронних органів і ЗМІ, в результаті яких вони доповнюють результати один одного, створюючи основу для більш ефективної роботи кожної зі сторін. Виокремлено напрями взаємодії ЗМІ з правоохоронними органами в Україні в умовах воєнного стану.

Враховуючи норми законодавства та суспільно-політичні реалії, що склалися в Україні, надано рекомендації щодо взаємодії правоохоронних органів із ЗМІ: 1) ухвалення окремого нормативно-правового акта, який би визначав основні принципи взаємодії правоохоронних органів із ЗМІ; обов’язки сторін, зокрема журналістів, поради та рекомендації щодо належного інформування громадськості про події, що відбуваються в Україні; 2) співпраця правоохоронних органів із засобами масової інформації має базуватися насамперед на засадах забезпечення безпеки осіб, а вже потім – на своєчасному інформуванні громадськості про події; 3) правоохоронним органам необхідно звернути особливу увагу на журналістів, які працюють у сфері забезпечення міжнародних стандартів, щоб вони у належний спосіб доносили інформацію як до цивільного населення, так і до міжнародної спільноти.
Diabetes Mellitus Incidence and the Risk of its Occurrence in Liquidators of the Chnpp Accident Consequences including Nuclear Industry Workers
Authors:   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Tukov A.R. , Shafransky I.L. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Prokhorova O.N. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Mikhailenko A.M. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Ziyatdinov M.N. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Published: December 2023

Summary: Investigation purposes Diabetes mellitus (DM) occupies the largest share in the structure of endocrine system diseases, nutritional disorders and metabolic disorders, which is currently one of the important priorities of national health systems. Research on certain groups of the population with their own harmful occupational risk factors is relevant. Analysis of the incidence of diabetes mellitus of the second type - T2DM (ICD 10: E11-E11.9) of liquidators of the consequences of the Chernobyl accident ‒ workers of nuclear industry enterprises for 30 years of observation and assessment of the radiation risk of its occurrence. Material and methods: The study includes data from the Industry register of persons exposed to radiation as a result of the Chernobyl accident over a thirty-year period, having a verified dose of external radiation received during work in the 30 km zone of the Chernobyl nuclear power plant, men – 12663 people, 1327, of whom have data on the dose of occupational irradiation. The Poisson process with an intensity parameter was chosen as a statistical model of morbidity. Results: The incidence of T2DM in liquidators of the consequences of the Chernobyl accident was estimated by age and sex groups. On the basis of the obtained file of individual unstratified data, an analytical likelihood function for the Poisson process was constructed and the value of the excess relative risk (ERR) of T2DM incidence was calculated and the nature of the dose dependence of RR was investigated. A cohort epidemiological study of a group of liquidators in 1986–1990 was carried out. over a thirty-year period, depending on the dose, both received during the liquidation of the consequences of the Chernobyl accident, and during professional work with radioactive substances (RS) and sources of ionizing radiation (IRS). Direct estimates of the radiogenic risk of diabetes mellitus are given. Different values ​​of risk were noted when using doses from different types of radiation. There was no significant increase in the risk of disease per dose unit (ERR / Sv). Conclusion: With the aging of the cohort of liquidators, an increase in the incidence of T2DM was noted in both men and women. The results obtained on the assessment of the radiation risk of T2DM at this stage are taken as preliminary, since the use of radiation risk in the development of radiation safety regulations requires a total dose from all types of exposure (professional, emergency, medical, natural).
Pelatihan Microsoft Office Dan Internet Trouble Shooting dalam Meningkatkan Pengetahuan Teknologi Informasi Pada Staff Sekretariat Daerah Pemerintah Kabupaten Bengkulu Tengah
Authors: Tiara Eka Putri  , Ferzha Putra Utama  , Nurul Renaningtias
Published: December 2023

Kegiatan pada Sekretariat Daerah Kabupaten Bengkulu Tengah sudah mulai terdigitalisasi dan online. Sebagai pendukung sarana dalam bekerja, pegawai Pemerintah Daerah Kabupaten Bengkulu Tengah dituntut menguasai Microsoft Office dan Internet Troubleshooting. Kondisi saat ini, kemampuan Staff Sekretariat daerah masih dikatakan kurang atau masih pada kemampuan dasar. Keterbatasan pengetahuan tersebut dikarenakan belum adanya pelatihan yang memadai terhadap Staff Sekretariat Daerah Pemerintah Kabupaten Bengkulu Tengah. Sehingga pelayanan kepada masyarakat dan pembuatan laporan atau surat menyurat memerlukan waktu yang lumanyan lama. Oleh karena itu, Pelatihan Microsoft Office dan Internet Troubleshooting perlu diberlakukan untuk menunjang kinerja pengawai pada Staff Sekretariat Daerah Pemerintah Kabupaten Bengkulu Tengah. Metode yang dilakukan dalam pengabdian ini adalah dengan melakukan pendampingan praktik langsung kepada peserta. Pengukuran atas pemahaman terkait dengan materi yang disampaikan akan dilakukan dengan menggunakan kuesioner online.  Khalayak sasaran pada pengabdian ini adalah 22 orang Perwakilan Staff Sekretariat Daerah Pemerintah Kabupaten Bengkulu Tengah.
Pengenalan Proses Produksi dan Pemanfaatan Herbal Kering Berkhasiat Obat pada Koperasi Perempuan Pelestari Hutan
Authors: Yuwana  , Syafnil  , Fatharani Arina
Published: December 2023

The target audience of community service activities was the Forest Conservation Women's Cooperative (KPPH), domiciled in Teladan Village, Curup District, Rejang Lebong Regency, Bengkulu Province, which manages a forest area with potential plants that could be cultivated and processed into herbal plants. One of them is pulutan leaves (Urena lobata L.) which have medicinal properties that residents in treating various diseases have used. These leaves have the potential to be dried herbs by transfer of Appropriate Technology (TTG) by introducing the process of pulutan leaves drying into dried herbs. The drying process was carried out using a dual heat collector solar energy dryer developed by the Department of Agricultural Technology. The process was analyzed to determine the drying time of pulutan leaves into dried herbs. For the next step, the leaves are packed to be stored. The process and utilization of pulutan leaves into dried herbs using a solar energy hybrid dryer required 8 hours and it was faster than the drying time in the open sun. The community service activities have been carried out well and successfully and provided benefits to the target audience.
Penerapan Budidaya Cabai Dengan Sistem Tanam Kombinasi Pada Kelompok Wanita Tani Anggrek Pematang Gubernur Kota Bengkulu
Authors: Herawati Reny , Ganefianti Dwi Wahyuni , Romeida Atra
Published: December 2023

Penggunaan lahan pertanian penduduk sebagian besar digunakan untuk persawahan dan kebun untuk kebutuhan keluarga yang ditanam sayuran seperti cabai tomat, terong, dan lain-lain.  Teknik budidaya cabai yang dilakukan masih sangat tradisional dan didominasi oleh serangan hama dan penyakit sehingga produktivitasnya sangat rendah.  Oleh karena itu perlu dilakukan pembinaan bagaimana mengoptimalkan pemanfaatan lahan pekarangan maupun kebun dengan teknologi budidaya cabai dengan sistem tanam kombinasi.  Kegiatan pengabdian masyarakat dengan topik “Penerapan Budidaya  Cabai dengan Sistem Tanam Kombinasi” dilaksanakan di Kelompok Tani Wanita Anggrek, Kelurahan Pematang Gubernur, pada bulan Agustus-November 2022. Penerapan budidaya cabai diterapkan di kebun masyarakat sebagai damplot KWT Anggrek  Pematang Gubernur. Pelaksanaan kegiatan melibatkan mahasiswa Program Studi Agroekoteknologi sebagai bentuk pembelajaran dalam transfer teknologi kepada masyarakat sebelum mereka terjun langsung ke masyarakat dalam melaksanakan program KKN.  Metode pengabdian dalam bentuk penyuluhan menyampaikan topik materi dan dilanjutkan dengan tanya jawab dan demplot di kebun masyarakat setempat. Penyampaian materi mulai dari pembibitan sampai panen. Kemudian dilanjutkan dengan membuat damplot dan peragaan cara menanam cabai dengan teknologi kombinasi beberapa varietas hibrida. Wawasan dan pengetahuan ibu-ibu KWT Anggrek semakin luas dari kegiatan pengabdian masyarakat tentang budidaya cabai dengan sistem tanam kombinasi, sehingga dapat mengurangi serangan hama dan penyakit, mengurangi penggunaan pestisida.  Hasil panen dapat dimanfaatkan untuk menambah pendapatan keluarga dan mengurangi biaya bumbu dapur untuk kebutuhan sehari-hari, bahkan dari hasilnya dapat menambah income keluarga. Untuk dapat berwirausaha secara mandiri diperlukan arahan secara kontinyu terutama bimbingan dalam mengolah hasil panen dengan berbagai macam olahan yang bernilai ekonomi dan dapat dipasarkan dengan jangkauan lebih luas.
A Case of Hypopharynx Perforation After Esophagogastroscopy
Authors: Park Joo Hyun , Jung Sungha , Kim Gangmi , Choi Nayeon
Published: December 2023

We report a case of endoscopic and open surgical treatment for iatrogenic perforation in the hypopharynx, a rare but potentially fatal complication of esophagogastroduodenoscopy. The patient was a 55-year-old female who exhibited strong resistance during passing through hypopharynx, leading to the suspicion of perforation, which was confirmed by CT scan and esophagography. Conservative management was attempted with antibiotics and prohibition of oral intake for 2 months, but she experienced worsening discomfort in the neck and was eventually readmitted for surgical treatment. The patient was treated with endoscopic mucosal repair and open surgery with regional flap. With the hypopharynx perforation healed, the patient was able to resume regular diet after a week and was discharged. Hypopharyngeal perforation that did not improve with long-term conservative treatment can be successfully treated through open surgery using a flap.
Incision and Drainage Versus Needle Aspiration for Peritonsillar Abscess: A Prospective Randomized Controlled Trial
Authors: Lee Jin , Han Seung Yoon , Kim Dong Hyun , Kwon Jung-Hun , Koo Hyung-Bon , Jeon Se Jeong , Lee Jeong Mi , Jin Young Ju
Published: December 2023

Background and Objectives Peritonsillar abscess (PTA) is an accumulation of pus between the palatine tonsil and pharyngeal constrictor muscle. It is a common cause of emergency on-call consultations among ENT doctors and occurs due to the possibility of sepsis, airway obstruction, and progression to deep neck infection. This study aims to compare the effectiveness of needle aspiration (NA) to incision & drainage (I&D) for the treatment of PTA.Subjects and Method From September 2018 to March 2020, 58 patients with PTA were admitted to our ENT Department. After a comprehensive diagnostic procedure, 38 patients were enrolled in the study and they underwent either I&D (20 patients) or NA (18 patients) treatment. Patients were discharged when edema decreased on the endoscopic findings and their symptoms improved, with a visual analogue scale (VAS) score <3 points. For each patient, we evaluated the abscess volume, age, body mass index, hypertension, diabetes mellitus, smoking and drinking history, abscess size, and duration of hospitalization. White blood cell (WBC) count, C-reactive protein (CRP) level, and erythrocyte sedimentation rate (ESR) were estimated on the 1st, 3rd, and 5th days of hospitalization.Results The mean age of participants was 42.8±15.5 years and 40.3±14.7 years in the I&D and NA groups, respectively. Except for ESR, the mean hospitalization duration, initial volume of abscess size, VAS pain score, WBC count and the CRP level were not different between the groups.Conclusion Our study revealed no significant differences in hospital stay duration, VAS score, WBC counts or in the CRP level among patients admitted for PTA, whether they underwent I&D or NA.
A Case Study on University Writing Class Applying Differentiated Instruction: Focusing on the “Basic Writing” Course at C University
Authors:   The Korean Society of Culture and Convergence, Kwon Yanghyeon
Published: December 2023

This paper proposes individualized instruction as a teaching method that allows learners with different characteristics to participate in the entire writing process and practice the essence of writing education. The analysis results of class operation that applied individualized instruction using the non-face-to-face class method implemented during the pandemic are as follows. First, the LMS system accumulates learner data and allows the instructor to check the learner's individual achievement and provide continuous individual guidance. At this time, the guidance for each learner is meaningful in that it allows the learner to actively intervene in the context of the class. Next, 1:1 feedback through Zoom is meaningful in that learners, by participating in the feedback process, embody that the essence of writing lies in communication and realize that reflecting on their own writing is also a part of writing. What is important is that these teaching methods can provide learners with opportunities and experiences as ‘doer of writing’.
Theatrical Performativity of the Mircrophone in Richard III Directed by Thomas Ostermeier
Authors:   The Korean Society of Culture and Convergence, Kim Sunae
Published: December 2023

Performativity of the microphone in Richard III directed by Thomas Ostermeir was examined, focusing on the symbolism and the mediality of microphone. Firstly, the microphone functions as a symbol of power. By occupying the center of the stage, it visually dominates the performance, and by amplifying sound, it acoustically dominates other sounds, thus taking control over the plot. Unlike traditional theater where the use of microphones is concealed, the use of the microphone is overtly displayed in the Ostermeier's Richard III. This overt coexistence of Shakespearean drama from his era and the modern technology of the microphone amplifies the sense of unfamiliarity and strengthens the alienation effect. Moreover, the protagonist, Richard, uses the microphone to delicately convey his inner self, engaging the audience in the events and eliciting empathy for the character.
A Semiotic Analysis of Narrative Structure in “Little Forest”
Authors:   The Korean Society of Culture and Convergence, Park SeungHyun
Published: December 2023

“Little Forest” is a Korean film, created by director Lim Soon-rye in 2018, This study aims to investigate the narrative structure of “Little Forest” through semiotic models, focusing on 'actant model’ and 'carre semiotique' suggested by Greimas. In the analysis applying actant model, the object of desire pursued by Hyewon, the protagonist of the movie, is a life that pursues self-sufficiency, cherishing present happiness in the countryside. As the object of desire becomes life filled with self-sufficiency, antagonist faction becomes urban life, where tensions and pressures are naturalized for the future. Since no character who forms a direct conflict with Hyewon in the film, the antagonist is not presented as a concrete figure but at an abstract level called urban life. When analyzed by carre semiotique, urban life is a life dictated by the present society that naturalizes competition and performance-oriented value. The forbidden area in the opposite relationship presented by carre semiotique is a life that pursues self-sufficiency, realizing human values that urban life in a capitalist society cannot provide. Revealing critical perspective on urban life in Seoul, the film gives a chance to rethink personal life that increases self-satisfaction.
Factors Affecting between Acculturation and Happiness of Immigrants in US: Mediating Effect of Language Ability
Authors:   The Korean Society of Culture and Convergence, Kim Eunmi
Published: December 2023

The purpose of this study is to find out the relationship between acculturation and influence of linguistic aspects as a factor influencing the happiness of immigrants in the eastern US.. The participants were immigrants who formed part of the Korean community in New York, US. These were 190 adults ranging in age from their 30s to their 80s who immigrated at various times. SPSS 23.0, and PROCESS Macro were used for data analysis. According to the correlation analysis results, there was a positive correlation between subjective language ability and happiness. Additionally, when examining the correlation between the independent variable and subjective language ability according to acculturation, separation was not significant, while relationship with assimilation, and marginalization was positively significant.As a result of verifying the effect on happiness through mediation of subjective language ability according to the type of acculturation, the indirect effect was statically significant in the type of assimilation, which was the independent variable. A higher level of assimilation, the higher the subjective evaluation of their language ability and the higher the level of happiness.
Inflammatory Status of Monocytes in Type 2 Diabetes Mellitus
Authors: Kirichenko T. V. , Bochkareva L. A. , Nedosugova L. V. , Markina Yu. V. , Kuzina I. A. , Petunina N. A. , Tolstik T. V. , Bogatyreva A. I. , Antonov V. A. , Markin A. M.
Published: December 2023

Сhronic inflammation is considered as a key factor in the development of type 2 diabetes mellitus. Impaired tolerance of the inflammatory response of monocytes is regarded as an important mechanism in the pathogenesis of chronic inflammation. In this work, we study the inflammatory activation and tolerance  of the immune response of monocytes in diabetes. In total, 40 patients with newly diagnosed diabetes   and 40 control group participants were included in the study. The level of basal, LPS-stimulated and re-stimulated secretion of the TNF-α, IL-1β, and MCP-1 cytokines was assessed in a monocyte culture isolated from the blood by immunomagnetic separation of CD14+ cells. The level of basal, LPS-stimulated and re-stimulated TNF-α secretion was significantly higher in patients with diabetes; the level of IL-1β secretion did not differ significantly between the groups; basal and re-stimulated MCP-1 secretion was also significantly higher in the diabetes group. Re-stimulated secretion of TNF-α and IL-1β was reduced compared to primary-stimulated secretion in both groups, demonstrating the tolerance of the macrophage immune response to these cytokines. Re-stimulated secretion of MCP-1 in 42% of diabetes patients was higher than primary stimulated secretion, thus revealing an impaired tolerance of the immune response of macrophages. A correlation was found between TNF-α secretion and body mass index, r=0.631, p<0.001, and with glycemic level, r=0.427, p=0.037. The results obtained demonstrate inflammatory activation     of monocytes with hypersecretion of TNF-α and MCP-1, impaired tolerance of the immune response of monocytes in diabetes regarding the secretion of MCP-1, as well as a correlation of TNF-α secretion   with body mass index and glycemic level. This indicates an important role of TNF-α and MCP-1 in the pathogenesis of chronic inflammation in type 2 diabetes, thus allowing these cytokines to be considered as potential therapeutic targets for pathogenetic therapy of type 2 diabetes.
Genoprotective Activity of Aronia melanocarpa Anthocyanin-Containing Complex
Authors: Rybalkina O. Yu. , Neupokoeva O. V. , Voronova O. L. , Razina T. G. , Kalinkina G. I. , Andreeva V. Yu. , Kiseleva E. A. , Churin A. A. , Zueva E. P. , Zhdanov V. V.
Published: December 2023

Anthocyanins are flavonoid compounds belonging to the group of polyphenols. A. melanocarpa (Michx.) Elliott chokeberry is known to be rich in these bioactive substances. The previously conducted chemical analysis showed that an anthocyanin-containing complex obtained from A. melanocarpa fruits comprise anthocyanins, flavonoids, phenolic acids, and catechins, with anthocyanins being the dominant components. A large amount of data indicates that Aronia fruits exhibit a wide spectrum of pharmacological activity. In this work, we assess the safety of an anthocyanin-containing complex obtained from A. melanocarpa fruits by its genotoxic study followed by an analysis of its effect on mutagenesis. To this end, a model of doxorubicin-induced genotoxicity in bone marrow cells of C57Bl/6 mice was used. The plant complex under study at a dose of 225 mg/kg had no effect the cytogenetic parameters of animal bone marrow cells after a single or double administration. The use of the anthocyanin-containing complex led to a decrease in DNA damage caused by the administration of doxorubicin, 24 and 48 hours after the introduction of a cytostatic agent. Hence, the data obtained can serve as the basis for the creation of a drug corrector for cycplasms.
POSTKOLESİSTEKTOMİ SONRASI NADİR İLEUS VAKASI: MECKEL DİVERTİKÜLİTİ
Authors: ÖZDEMİR Muhammed
Published: December 2023

Meckel divertüliti toplumda görülme sıklığı % 2-3 olup, en sık görülen konjenital gastrointestinal anomalidir (1). Çoğu zaman operasyon sırasında tesadüfen tanı almakla beraber enflamasyonunda hayatı tehdit eden birçok ciddi komplikasyonlara neden olabilir. Bu çalışmamızda 54 yaşında erkek hastanın kolesistektomi sonrası 3. günde Meckel divertikülitine bağlı internal herniasyon ve takibinde gelişen ileus hastası sunulmaktadır.
MENURUNKAN CACAT SHRINK PLASTIK PADA PRODUK BOTOL BEDAK MENGGUNAKAN METODE SIX SIGMA
Authors: Noviyanti Aisah , Khamaludin Khamaludin , Firdaus M. Yus
Published: December 2023

PT XYZ merupakan salah satu sektor industri yang memproduksi produk kosmetik atau perawatan tubuh. Dengan selalu berusaha meyakinkan konsumen dengan kualitas hasil produk yang baik. Dengan ini perusahaan selalu berupaya untuk mengoptimalkan dan mengelola produk dan sumber daya manusianya. Permasalahan yang terjadi pada perusahaan ini diakibatkan oleh buruknya kualitas penyusutan sehingga perusahaan berusaha untuk mengurangi kecacatan dari hasil proses tersebut. Pengendalian kualitas merupakan suatu langkah pengendalian suatu permasalahan pada suatu produk agar dapat menghasilkan kualitas yang baik sesuai dengan harapan pelanggan. Six Sigma merupakan suatu metode dalam mengendalikan suatu masalah secara terstruktur. DMAIC (Define, Measure, Analyze, Improve, Control) menjadi ukuran dalam menjalankan proses Six Sigma. Hasil penelitian membuktikan bahwa dalam penerapannya metode ini dapat mengurangi akibat cacat pada proses produk dan bermanfaat bagi perusahaan untuk meningkatkan keuntungan serta sebagai pengalaman sehingga apabila permasalahan tersebut terjadi kembali perusahaan dapat mengetahui cara mengatasinya.
Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia
Authors: van der Heijden Meike E. , Sillitoe Roy V.
Published: December 2023

Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network. There is mounting evidence suggesting that the cerebellum is a central node in this network. For example, manipulations that target the cerebellum cause dystonic symptoms in mice, and cerebellar neuromodulation reduces these symptoms. Although numerous findings provide insight into dystonia pathophysiology, they also raise further questions. Namely, how does cerebellar pathophysiology cause the diverse motor abnormalities in dystonia, tremor, and ataxia? Here, we describe recent work in rodents showing that distinct cerebellar circuit abnormalities could define different disorders and we discuss potential mechanisms that determine the behavioral presentation of cerebellar diseases.
Phase characteristics of vocal tract filter can distinguish speakers
Authors: Okada Masahiro , Ito Hiroshi
Published: December 2023

Introduction

Speaker recognition has been performed by considering individual variations in the power spectrograms of speech, which reflect the resonance phenomena in the speaker's vocal tract filter. In recent years, phase-based features have been used for speaker recognition. However, the phase-based features are not in a raw form of the phase but are crafted by humans, suggesting that the role of the raw phase is less interpretable. This study used phase spectrograms, which are calculated by subtracting the phase in the time-frequency domain of the electroglottograph signal from that of speech. The phase spectrograms represent the non-modified phase characteristics of the vocal tract filter.

Methods

The phase spectrograms were obtained from five Japanese participants. Phase spectrograms corresponding to vowels, called phase spectra, were then extracted and circular-averaged for each vowel. The speakers were determined based on the degree of similarity of the averaged spectra.

Results

The accuracy of discriminating speakers using the averaged phase spectra was observed to be high although speakers were discriminated using only phase information without power. In particular, the averaged phase spectra showed different shapes for different speakers, resulting in the similarity between the different speaker spectrum pairs being lower. Therefore, the speakers were distinguished by using phase spectra.

Discussion

This predominance of phase spectra suggested that the phase characteristics of the vocal tract filter reflect the individuality of speakers.
Chemical contributions to silicon anode calendar aging are dominant over mechanical contributions
Authors: McBrayer Josefine D. , Harrison Katharine L. , Allcorn Eric , Minteer Shelley D.
Published: December 2023

Silicon (Si) anodes are a promising candidate for increasing the energy density of lithium (Li)-ion batteries for electric vehicles. However, they have recently been identified as having poor calendar life that is insufficient for commercial needs, in addition to the well-known issue of their poor cycle life resulting from large volume expansion. Here, a specially designed protocol with variable rest periods between intermittent cycling is used to evaluate the impact of the mechanical disruption of Si and solid electrolyte interphase (SEI) from cycling on calendar aging measurements. Si was found to undergo more mechanical degradation during calendar aging with intermittent cycling than graphite. However, Si anode capacity fade was still dominated by time, especially for rest periods greater than or equal to 1 month between cycling. Postmortem dQ/dV half-cell analysis indicated this was mainly due to Li inventory loss and an increase in electrode resistance. Isothermal microcalorimetry further demonstrated that Si passivation is more disrupted than graphite passivation with intermittent cycling and suggested that there may be a chemical buildup of a detrimental species in the electrolyte, leading to a large spike in heat after the Si and SEI are disrupted by cycling.
The benefits of GLP1 receptors in cardiovascular diseases
Authors: Ferhatbegović Lamija , Mršić Denis , Macić-Džanković Amra
Published: December 2023

Glucagon like peptide-1 (GLP-1) receptor agonists are well established drugs for the treatment of type 2 diabetes (T2D). In addition to glycemic control, GLP-1 receptor agonists have beneficial other effects. They act by binding to GLP-1 receptors, which are widely distributed in the body, including cardiomyocytes and blood vessels. The aim of this article is to provide a comprehensive review of GLP-1 receptor agonists impact on cardiovascular outcomes and risk reduction. In the last decade, several cardiovascular outcomes trials (CVOT) have been conducted in order to explore cardiovascular benefit of GLP-1 receptor agonists. CVOTs primarily proved cardiovascular safety and tolerability of different GLP-1 receptor agonists, but also showed cardiovascular benefit of specific drugs. CVOTs have shown that GLP-1 receptor agonists reduce MACE in patients with T2D compared to placebo. In addition, they have positive impact on several cardiovascular risk factors such as obesity by promoting weight loss, blood pressure and blood lipid levels. Also, they stimulate the endothelium to produce nitric oxide, reduce oxidative stress, and have antiatherogenic and antiinflammatory effects. Studies have shown their positive impact on kidney outcomes in patients with T2D compared to placebo. The results of previous trials are encouraging in terms of multiple positive effects of GLP-1 receptor agonists. However, further research is needed to understand their full potential and all details of their mechanism of action, which will enable to expand the therapeutic indications and to determine their optimal use in clinical practice.
Functional specialization of Aurora kinase homologs during oogenic meiosis in the tunicate Oikopleura dioica
Authors: Feng Haiyang , Thompson Eric M.
Published: December 2023

A single Aurora kinase found in non-vertebrate deuterostomes is assumed to represent the ancestor of vertebrate Auroras A/B/C. However, the tunicate Oikopleura dioica, a member of the sister group to vertebrates, possesses two Aurora kinases (Aurora1 and Aurora2) that are expressed in proliferative cells and reproductive organs. Previously, we have shown that Aurora kinases relocate from organizing centers to meiotic nuclei and were enriched on centromeric regions as meiosis proceeds to metaphase I. Here, we assessed their respective functions in oogenic meiosis using dsRNA interferences. We found that Aurora1 (Aur1) was involved in meiotic spindle organization and chromosome congression, probably through the regulation of microtubule dynamics, whereas Aurora2 (Aur2) was crucial for chromosome condensation and meiotic spindle assembly. In vitro kinase assays showed that Aur1 and Aur2 had comparable levels of kinase activities. Using yeast two-hybrid library screening, we identified a few novel interaction proteins for Aur1, including c-Jun-amino-terminal kinase-interacting protein 4, cohesin loader Scc2, and mitochondrial carrier homolog 2, suggesting that Aur1 may have an altered interaction network and participate in the regulation of microtubule motors and cohesin complexes in O. dioica.
Development of a monoclonal antibody and a lateral-flow device for the rapid detection of a Mucorales-specific biomarker
Authors: Thornton Christopher R. , Davies Genna E. , Dougherty Laura
Published: December 2023

Mucoromycosis is a highly aggressive angio-invasive disease of humans caused by fungi in the zygomycete order, Mucorales. While Rhizopus arrhizus is the principal agent of mucoromycosis, other Mucorales fungi including Apophysomyces, Cunninghamella, Lichtheimia, Mucor, Rhizomucor and Syncephalastrum are able to cause life-threatening rhino-orbital-cerebral, pulmonary, gastro-intestinal and necrotising cutaneous infections in humans. Diagnosis of the disease currently relies on non-specific CT, lengthy and insensitive culture from invasive biopsy, and time-consuming histopathology of tissue samples. At present, there are no rapid antigen tests that detect Mucorales-specific biomarkers of infection, and which allow point-of-care diagnosis of mucoromycosis. Here, we report the development of an IgG2b monoclonal antibody (mAb), TG11, which binds to extracellular polysaccharide (EPS) antigens of between 20 kDa and 250 kDa secreted during hyphal growth of Mucorales fungi. The mAb is Mucorales-specific and does not cross-react with other yeasts and molds of clinical importance including Aspergillus, Candida, Cryptococcus, Fusarium, Lomentospora and Scedosporium species. Using the mAb, we have developed a Competitive lateral-flow device that allows rapid (30 min) detection of the EPS biomarker in human serum and bronchoalveolar lavage (BAL), with a limit of detection (LOD) in human serum of ~100 ng/mL serum (~224.7 pmol/L serum). The LFD therefore provides a potential novel opportunity for detection of mucoromycosis caused by different Mucorales species.
Multi-dimension metabolic prognostic model for gastric cancer
Authors: Feng Wanjing , Xu Bei , Zhu Xiaodong
Published: December 2023

Background

Metabolic reprogramming is involved in different stages of tumorigenesis. There are six widely recognized tumor-associated metabolic pathways, including cholesterol catabolism process, fatty acid metabolism, glutamine metabolic process, glycolysis, one carbon metabolic process, and pentose phosphate process. This study aimed to classify gastric cancer patients into different metabolic bio-similar clusters.

Method

We analyzed six tumor-associated metabolic pathways and calculated the metabolic pathway score through RNA-seq data using single sample gene set enrichment analysis. The consensus clustering analysis was performed to classify patients into different bio-similar clusters by multi-dimensional scaling. Kaplan–Meier curves were presented between different metabolic bio-similar groups for OS analysis.

Results

A training set of 370 patients from the Cancer Genome Atlas database with primary gastric cancer was chosen. Patients were classified into four metabolic bio-similar clusters, which were identified as metabolic non-specificity, metabolic-active, cholesterol-silence, and metabolic-silence clusters. Survival analysis showed that patients in metabolic-active cluster and metabolic-silence cluster have significantly poor prognosis than other patients (p=0.031). Patients in metabolic-active cluster and metabolic-silence cluster had significantly higher intra-tumor heterogeneity than other patients (p=0.032). Further analysis was performed in metabolic-active cluster and cholesterol-silence cluster. Three cell-cycle-related pathways, including G2M checkpoints, E2F targets, and MYC targets, were significantly upregulated in metabolic-active cluster than in cholesterol-silence cluster. A validation set of 192 gastric cancer patients from the Gene Expression Omnibus data portal verified that metabolic bio-similar cluster can predict prognosis in gastric cancer.

Conclusion

Our study established a multi-dimension metabolic prognostic model in gastric cancer, which may be feasible for predicting clinical outcome.
Study of the space–time transition and spatial spillover effects of tourism green production efficiency in the Yangtze River Delta—a reanalysis from the perspective of tourism carbon sinks
Authors: Shi Pengfei , Long Huibing , Yao Yikun , Li Xingming , Wang Xinrui
Published: December 2023

Tourism green production efficiency serves as the foundation for assessing the mutual coupling performance of the tourism economy and the ecological environment. In this paper, the tourism carbon sink is included in the measurement framework, and the TGPE of 41 cities in the Yangtze River Delta region from 2011 to 2019 is estimated by the Super-SBM model. Furthermore, kernel density estimate, spatial autocorrelation, Markov chain and spatial Durbin model are further integrated to explore its spatio-temporal evolution process, spatial effects and influencing factors. The results show that 1) TGPE in the Yangtze River Delta has been increasing during the study period. The high-efficiency and low-efficiency areas of the TGPE have a bipolar pattern characterized by “low–low convergence” and “high–high convergence.” 2) There is considerable spatial variation in TGPE from north to south. The number of hot spots and sub-hot spots increases in volatility, whereas the number of sub-cold spots and cold spots decreases. 3) Although cities with low levels of TGPE have a higher probability of moving to the next level, grade transformation across hierarchies is difficult to attain. When considering the factor of adjacent types and the influence of spatial lag on the transfer probability. 4) The positive spatial spillover effects of TGPE is significant. At the same time, economic development level, transport accessibility and tourism industry agglomeration have positive spillover effects on neighboring cities. Conversely, urbanization level and openness level have negative spillover effects.