bluuebunny/crossref_metadata_2025 huggingface dataset:
Filantropi dan Strategi Dakwah terhadap Mualaf: Kolaborasi Mualaf Center Yogyakarta, Dompet Dhuafa, dan Rumah Zakat di Yogyakarta
Authors: Sinta Ari Dyah , Isbah M Falikul
Published: September 2019

Existing studies have explored philanthropy as fund management practices for economic empowerment of the poor, or building infrastructure such as hospitals, schools, and Islamic boarding schools. This paper portrays another aspect, the role and strategy of Islamic philanthropy organisations in dakwah movement among newly-converted (muallaf) in Yogyakarta. Dakwah activities are normally conducted by dai in mosques through regular sermons. However, that method was considered as less effective as the task of dai is seen to be accomplished when the muallaf recite shahadat. The data here is drawn from a fieldwork at Mualaf Center Yogyakarta (MCY), and its collaboration with Dompet Dhuafa and Rumah Zakat. This research aimed to explore new forms of action by philanthropic organisations in their use of public fund. Through a qualitative approach and a case study method at MCY, this research found that MCY was in partnership with Dompet Dhuafa dan Rumah Zakat in their work. MCY was in charge in supporting spiritual and psychological aspect of muallaf, while Dompet Dhuafa and Rumah Zakat were in charge in empowering the economic and welfare of muallaf. Before receiving such support, the muallaf faced difficulties in conducting Islamic teachings such as praying, fasting, and ablution. After receiving the support, they found easier in fulfilling those.
Análise do discurso multimodal de um vídeo com conteúdo matemático
Authors: Neves Liliane , Borba Marcelo
Published: September 2019

O papel educativo das mídias digitais se destaca no cenário atual do qual os vídeos sobressaem pelo estímulo aos sentidos na produção de conhecimento, levando à uma nova forma de conhecer. Nesse contexto, a pesquisa apresentada neste artigo analisa como estudantes realizam intersemioses ao expressarem ideias matemáticas em vídeos e o papel da tecnologia nesse processo. As intersemioses são combinações de recursos semióticos e possibilitam expansões semânticas no discurso matemático. A pesquisa foi desenvolvida com licenciandos em Matemática da educação a distância. A metodologia foi qualitativa e a observação participante virtual foi o procedimento utilizado na produção dos dados. A Sistêmico Funcional – Análise do Discurso Multimodal fundamentou a investigação. Este artigo apresenta um recorte da análise de um dos vídeos dessa pesquisa, da qual se conclui que gestos e música combinados com linguagem, simbolismo e imagens possibilitam a transformação do conhecimento pela expansão semântica no discurso matemático digital.
Palavras-chave: Intersemiose. Tecnologias Digitais. Educação a distância.
Contribuições do GeoGebra nas dialéticas de uma situação didática para o estudo das Medidas de Tendência Central
Authors: Araújo José , Abar Celina
Published: September 2019

Neste artigo, tecemos reflexões acerca das contribuições do GeoGebra nas dialéticas de uma situação didática envolvendo as Medidas de Tendência Central. Oriundo dos resultados de uma pesquisa de mestrado que teve como objetivo investigar as potencialidades do GeoGebra para o estudo das Medidas de Tendência Central, que foram apresentados no XIII Encontro Nacional de Educação Matemática, sob o ponto de vista teórico. o estudo recorreu às dialéticas de ação, formulação e validação e institucionalização, presentes na Teoria das Situações Didáticas. Numa abordagem qualitativa, adotou-se pressupostos da Engenharia Didática para desenvolver, aplicar e analisar a sequência de atividades. Aplicado a alunos egressos do 9º ano do Ensino Fundamental, os resultados do estudo apontaram que na proposta das atividades, nas diferentes dialéticas, as múltiplas representações dos dados no GeoGebra constituíram uma vantagem didática que contribuiu para a compreensão e análise dos dados, contribuindo para o estudo das Medidas de Tendência Central.

Palavras-chave: GeoGebra. Medidas de Tendência Central. Teoria das Situações Didáticas. Engenharia Didática. Múltiplas Representações.
Um olhar sobre as questões étnicas-raciais nas enunciações sobre a história da Matemática apresentadas pelos livros didáticos de Matemática do Ensino Médio aprovados pelo PNLD 2018
Authors: Manoel Alan Pereira , Coradetti Camila Aparecida Lopes Manoel
Published: September 2019

O presente texto é constituído de estudos realizados no Programa de Pós-Graduação em Educação Matemática da Universidade Federal de Mato Grosso do Sul (PPGEdumat/UFMS) e se inscreve na linha de pesquisa “Currículo e Educação Matemática”.  O objetivo deste artigo é descrever e analisar discursos mobilizados na abordagem feita, acerca da História dos Conjuntos, contidas nos livros didáticos do Ensino Médio, aprovados no PLND 2018. Para alcançar esse objetivo foram utilizadas as contribuições teóricas da análise do discurso na perspectiva foucaultiana e as contribuições de cultura, identidade e representação de Stuart Hall. Nas análises foram observados um currículo de Matemática, enquanto campo político, que, ao apresentar determinadas representações sobre a história da Matemática, provoca o apagamento de questões étnicos-raciais, principalmente aquelas relacionadas à cultura popular negra, por meio de uma hegemonização da cultura ocidental, a partir de seus feitos históricos, em contexto científicos e áreas afins.Palavras-chave: Educação Matemática. Currículo. Análise do discurso. Cultura. Representação. A look at the ethnic-racial issues in the Math history presentations presented by the 2018 PNLD medical education Mathematical booksAbstract: This text consists of studies carried out in the Graduate Program in Mathematical Education of the Federal University of Mato Grosso do Sul (PPGEdumat / UFMS) and is part of the research line "Curriculum and Mathematical Education". The aim of this article is to describe and analyze discourses mobilized in the approach made, about the History of the Sets, contained in the High School textbooks, approved in PLND 2018. To achieve this objective, the theoretical contributions of discourse analysis were used from the Foucaultian perspective and the contributions of culture, identity and representation of Stuart Hall. In the analyzes, a mathematics curriculum was observed as a political field, which, by presenting certain representations about the history of mathematics, causes the erasure of ethnic-racial issues, especially those related to black popular culture, through a hegemonization of western culture, from their historical achievements, in scientific context and related fields.Keywords: Mathematical education. Curriculum. Speech analysis. Culture. Representation.
Community Psychology Perspective on Ecological Issues: Based on Psychological Intervention
Authors: Mehrad Aida
Published: September 2019

The purpose of the current literature review is to clarify the important role of community psychology regarding ecological issues and illustrated its critical function based on psychological intervention. The results of this investigation explained that community psychology as one of the essential fields of psychology, has substantial involvement on ecological issues and it can examine these issues based on psychological intervention. In truth, these ecological issues that some of them explained in this study (child maltreatment, drug addiction, school dropping out, and teen pregnancy) have been examined based on the psychological aspect for finding best solution way from the side of expert psychologists and counselors. Consequently, this research focused on teenagers that face with community issue via different ways, and should be considered by parents, schools, society, and government in every community and country; otherwise, it will appear any inconvenient behaviors and reactions amongst teenagers.
Social Work in The Greek Schools: A Review of Policy Texts
Authors: Lempesi Georgia Eleni
Published: September 2019

Social work is an applied science that finds application in a multitude of fields, health, education, social protection, protection of the elderly, addiction, human rights, etc. Specifically, in the field of education both in America and in European countries, the social worker has an active presence in schools in various forms. This article will analyze the evolution of the role of the social worker in education in Greece through the study of the legislative framework from 1975 to 2018.
Carcass Characteristics and Meat Quality of Conventionally and Organically Reared Suckling Dairy Goat Kids of the Payoya Breed
Authors: Guzmán José Luis , de la Vega Francisco , Zarazaga Luis Ángel , Argüello Anastasio , Delgado-Pertíñez Manuel
Published: September 2019

The viability of conventional goat farms, such as the native Payoya dairy goat, could be improved by switching to organic production, but product quality needs to be ensured. The present work assesses the carcass and meat quality of Payoya kids raised under conventional and organic grazing-based systems. Twenty-four kids (12 males, 12 females) were selected from each system (n = 48). The slaughter live weight (8.52 vs. 8.28 kg), cold carcass weight (4.44 vs. 4.29 kg) and farm dressing percentage (51.7 vs. 50%) of the conventionally raised kids were significantly higher than those of the organic kids. The shoulder (first category) (21.7 vs. 22.3%) and long leg (32 vs. 32.9%) percentages were lower in the conventional than in the organic kids. The percentage contribution of the intermuscular fat (10.70 vs. 8.11%) to the shoulder weight was greater in the conventional kids, while the percentages of muscle (59.7 vs. 57.2%) and bone (24.7 vs. 22.8%) were higher in the organic kids. For the chemical composition, there were only differences between the two sexes in the percentage of fat (6.64 and 7.99% on dry matter, for male and female, respectively). For rheological variables, only differences were found in the water holding capacity (% water expelled), the meat of the organic females had a higher value (17%) than that of the conventional females (14%). For the meat colour, the conventional male kids returned the highest values for C* and Hº (14.32 and 64.34, respectively). Farms following conventional grazing-based management could easily switch to organic production. Most of the meat and carcass quality variables studied were very similar across the systems.
The state of bio-ecological characteristics of the one-year shoots of Robinia pseudoacacia L. Under the conditions of industrial pollution
Authors: Yusypiva Tetiana , Miasoid Halyna
Published: September 2019

The paper studies the influence of industrial pollution on bio-ecological characteristics of the one-year shoot of Robinia pseudoacacia L. in the conditions of the city of Dnipro, Ukraine. It analyses the state of biometric parameters of the shoot and anatomic indices of the stem of the studied species exposed to toxic gases. It was found that there are adaptive changes in the histological structure of the stem of R. pseudoacacia under the conditions of technogenesis. The study revealed that bio-ecological characteristics of the black locust are highly resistant to industrial emissions with big shares of SO2 and NO2. It was suggested to use R. pseudoacacia for greening of the technogenic territories.
Microalgae Harvesting: A Review
Authors: Kucmanová Alexandra , Gerulová Kristína
Published: September 2019

Microalgae are photosynthetic autotrophic microscopic organisms growing in a range of aquatic and terrestrial habitats. They produce a huge complex of compounds in their surroundings which are of important use to humans. Their commercial use lies in human nutrition, animal and aquatic feed, in cosmetics products, natural pigments, pharmaceutical industry, bio-fertilizer for extracting high-value molecules, stable isotope biochemicals, and for the synthesis of antimicrobial, antiviral, antibacterial and anticancer drugs. Therefore, it is necessary to develop a simple, effective and economically advantageous method for harvesting the algal products. Magnetic separation is a simple separation process. Different synthesis methods have been used by researchers to obtain magnetic particles of varying size and shapes according to the algae to be studied. Chemical co-precipitation method has been the most commonly used method, which helps in synthesizing magnetic particles of the micro to nano range. Naked, coated and surface modified are the general types of magnetic particles used for algal harvesting with its own advantages and disadvantages.
First record of Platyscapa quadraticeps (Hymenoptera: Chalcidoidea: Agaoninae) in Colombia: A warning sign?
Authors: Cardona William
Published: September 2019

The first occurrence record of Platyscapa quadraticeps in Colombia is reported. This wasp is the pollinator of Ficus religiosa, a tree species introduced mainly for ornamental use. The obligate mutualistic relationship between them could result in the naturalization of both species, with possible negative consequences.
Assessment of Knowledge of Neonatal Jaundice among Mothers Attending Maternal and Pediatric Hospital in Soran City
Authors: Jamal Hamad Kareem , Muhammad Khalil Haroon
Published: September 2019

Neonatal jaundice is one of the most common and serious conditions requiring medical attention. Early discharge of neonates before the onset of jaundice would reduce access to treatments and mothers act critical role in managing condition. Therefore, this study set out to assess the mothers’ knowledge of neonatal jaundice. A descriptive study was conducted from January to May 2018, using random sample of 100 mothers attended maternal and pediatric hospital in Soran city during antenatal visit. Data were collected through the use of a specially designed questionnaire for the purpose of the study. The finding of the study shows that 36% of mothers were in the age group of 25–30 years. Majorities (84%) were Muslim, 76% of them were housewives, and 49% was multipara. Another major finding revealed that most of the mothers (88%) had poor knowledge of neonatal jaundice. Results show a significant association between education level, occupation of mothers, and their knowledge of neonatal jaundice. This study revealed that mothers had poor knowledge and there was a dramatic lack of knowledge regarding causes and danger signs of neonatal jaundice. Education level and occupation status had a significant impact on mothers’ knowledge. It is recommended more attention on educating mothers during antenatal visits, as well as proper training health-care providers, updating their knowledge and teaching methods.
Effect of Ploughing Depth, Tractor Forward Speed, and Plough Types on the Fuel Consumption and Tractor Performance
Authors: Ibrahim kareem Kareem , Sven P.
Published: September 2019

Cost of fuel has a significant impact on the input costs of agricultural production, especially during primary tillage. It is affected by several parameters including tractor forward speed, depths of ploughing, and plough types. The experiment was performed in a Soil Hall at Harper Adams University, United Kingdom, in April 2015. A Massey Ferguson 8480 4WD tractor was used for investigating objectives of this study. The experiment was performed in a sandy loam soil texture at 11.73% soil moisture content and 1.35 (g/cm3) dry bulk density to study the amount of fuel consumption (l/ha) and the performance of tractor with effect of moldboard and disc ploughs as ploughs type, 15 and 20 cm as ploughing depth and 5 and 7 km/h as tractor forward speeds. The results showed that fuel consumption with a disc plough 5% was higher compared to the moldboard. Fuel consumption decreased approximately 8% when tractor at 7 km/h. Fuel consumption significantly decreased about 34% when ploughing depth increased from 15 to 20 cm. The power requirement to operate moldboard plough was higher by about 14% than a disc. The power requirement at speeds of 7 km/h was higher compared to the speeds of 5 km/h by about 27%. When the depth of ploughing increased from 15 to 20 cm, the power requirement increased by about 1.5%.
Production of Lightweight Thermal Insulating Clay Bricks using Papyrus
Authors: Muhamad Ali Karim Hussein
Published: September 2019

The paper presents an experimental investigation into the possibility of producing lightweight clay bricks by adding flakes of papyrus, locally called (Bardy). The flakes were sieved to obtain a powder with maximum particle size of 2.5 mm. The bricks were prepared with the addition of increasing amounts of flakes of papyrus (0, 10, 20, 30, and 40 mass%) to the clay slurry. Different temperatures of 650, 900, and 1050°C were embayed to fire the specimens. The thermal conductivity, water absorption, porosity, bulk density, firing shrinkage, compressive strength, and bending strength of the samples were measured. It was observed that the apparent compressive strength, bending strength, firing shrinkage, thermal conductivity, and density increased with the firing temperature increase and decreased with the papyrus flakes content increase; however, water absorption and porosity showed an opposite behavior.
The Role of Intellectual Capital on Financial Decision Making in Private Universities in Erbil City – Iraq
Authors: Gül Reís Ş , M. Saeed Luqman , Mohammed Abdullah Kamal
Published: September 2019

The purpose of the study is to examine the role of intellectual capital on financial decision making in private universities in Erbil. To achieve this purpose, the sample of the study collected from participating 115 managers at six private universities locating in Erbil city in Iraq. The dependent variable of the study is financial decision making. Independent variables are human capital, structural capital, and customer capital which are dimensions of intellectual capital according to Stewart model. In the methodology part of the study, the importance of working by focusing on some of the questions, posing the relationship between the independent and dependent variables, and the effectiveness have been determined. Accordingly, a conceptual model design of the study and then produce two main hypotheses to test. This has been subjected to numerous statistical tests. The study results; the most notable one is the existence of the highest rank of importance of human capital among intellectual capital components, while the customer and structural capitals come second and third, respectively. In addition, this result shows that the human, structural, and customer capitals affect financial decision making in Erbil private universities.
Prevalence, Severity, and Correlates of Pain Flares in Response to a Repeated Sit-to-Stand Activity: A Cross-sectional Study of 14 902 Patients With Knee and Hip Osteoarthritis in Primary Care
Authors: Skou Søren T. , Grønne Dorte T. , Roos Ewa M.
Published: September 2019

Objective

To determine prevalence, severity, and clinical correlates of pain flares in response to a repeated sit-to-stand activity.

Design

Cross-sectional.

Methods

The analyses included 11 013 patients with knee osteoarthritis (OA) and 3889 patients with hip OA who completed a 30-second chair-stand test before starting the Good Life with osteoArthritis in Denmark treatment program. Prevalence and severity of pain flares were evaluated by change in self-reported joint pain intensity on an 11-point numeric rating scale after the test. Correlates with pain flares (an increase on the numeric rating scale of 2 points or greater) were assessed using regression analyses.

Results

One out of 3 patients with knee OA and 1 out of 5 patients with hip OA experienced pain flares (numeric rating scale of 2 or greater). Low knee/hip confidence, 3 or more painful body sites, fewer than 12 chair stands in 30 seconds, and body mass index of 30 kg/m2 or greater were associated with pain flares in response to the 30-second chair-stand test in patients with knee and hip OA. Low self-efficacy and joint stiffness were associated with pain flares in patients with knee OA. Using pain medication was associated with pain flares in patients with hip OA.

Conclusion

Pain flares in response to a repeated sit-to-stand activity were common in patients with knee and hip OA. The clinical correlates associated with pain flares included joint confidence, functional performance, and body mass index, and are potentially modifiable with patient education, exercise therapy, and weight loss, respectively. J Orthop Sports Phys Ther 2020;50(6):309–318. Epub 6 Sep 2019. doi:10.2519/jospt.2019.9125
Photoredox-Catalyzed Intermolecular Radical Addition to Allenamides: A Complementary Approach to Conjugated N-Acyliminium Formation.
Authors: Koleoso Kayode , Turner Matthew , Plasser Felix , Kimber Marc
Published: September 2019

An intermolecular radical addition, using photoredox catalysis, to allenamides is reported. This transformation synthesizes N-acyl-N’-aryl-N,N’-allylaminals, and proceeds by a conjugated N-acyliminium intermediate, that previously, has only been generated by electrophilic activation methods. The radical adds to the central carbon of the allene giving a conjugated N-acyliminium, that undergoes nucleophilic addition by arlyamines and alcohols.
Simultaneous Determination of Per- and Polyfluoroalkyl Substances and Bile Acids in Human Serum Using Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry
Authors: Salihovic Samira , Dickens Alex , Schoultz Ida , Fart Frida , Sinisalu Lisanna , Lindeman Tuomas , Halfvarsson Jonas , Oresic Matej , Hyötyläinen Tuulia
Published: September 2019

There is evidence of a positive association between per- and polyfluoroalkyl substances (PFAS) and cholesterol levels in human plasma, which may be due to common reabsorption of PFAS and bile acids (BAs) in the gut. Here we report development and validation of a method that allows simultaneous, quantitative determination of PFAS and BAs in plasma, using 150 uL or 20 uL of sample. The method involves protein precipitation using 96-well plates. The instrumental analysis was performed with ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS), using reverse-phase chromatography, with the ion source operated in negative electrospray mode. The mass spectrometry analysis was carried out using multiple reaction monitoring mode. The method proved to be sensitive, robust and with sufficient linear range to allow reliable determination of both PFAS and BAs. The method detection limits were between 0.01 and 0.06 ng⋅mL-1 for PFAS and between 0.002 and 0.152 ng⋅mL-1 for BAs, with the exception of glycochenodeoxycholic acid (0.56 ng⋅mL-1). The PFAS measured showed excellent agreement with certified plasma PFAS concentrations in NIST SRM 1957 reference plasma. The method was tested on serum samples from 20 healthy individuals. In this proof-of-concept study, we identified significant associations between plasma PFAS and BA levels, which suggests that PFAS may alter the synthesis and/or uptake of BAs.
Analysis of the effectiveness of joint or sequential vaccination with pneumococcal and influenza vaccines in patients with chronic obstructive pulmonary disease
Authors: Ignatova G L , Antonov V N , Blinova E V
Published: September 2019

One of the extremely important problems of managing patients with chronic obstructive pulmonary disease (COPD) is to prevent exacerbations. The article presents data on the clinical and economic efficiency of joint vaccine prevention of conjugate pneumococcal vaccine Prevenar 13 (PCV13) and SOVIGRIPP flu vaccine in patients with COPD. Material and methods. 153 patients were included in the study. They were divided into three groups. The first group (n=53) - consisted of patients who were vaccinated with PCV13. The second group (n=51) included patients who were vaccinated with PCV13 and influenza vaccine simultaneously or with an interval of not more than 2 weeks. The third group (n=49) included not vaccinated patients. The observation period is 1 year. Results and discussion. Combined vaccine prevention of pneumococcal conjugate and influenza vaccines reduces the degree of clinical impairment and stabilizes the main functional parameters of the respiratory system at a significantly lower level compared to monovaccination with only pneumococcal vaccine. Single - stage vaccination with PCV13 and influenza vaccine reduces the risk of adverse events in COPD, reduces the number of exacerbations associated with this hospitalization of patients and the incidence of pneumonia. Conclusion. Combined vaccination with the use of two vaccines minimizes the costs of the health care system. The budget savings can reach an average of 80-83% per year or up to 26 967 - 28 001 rubles per patient with COPD.
Gastroesophageal reflux disease and esophagitis associated with the use of drugs: the modern state of the problem
Authors: Osadchuk A M , Davydkin I L , Gricenko T A , Osadchuk M A
Published: September 2019

From the standpoint of evidence - based medicine, the ability of various drugs to induce the development of gastroesophageal reflux disease and esophagitis is considered. Thus, all known drugs can be divided into 3 groups: drugs that have the ability to reduce pressure in the lower esophageal sphincter, for example, β-adrenoreceptor agonists, α-adrenoreceptor antagonists, anticholinergics, calcium channel blockers, nitrates, benzodiazepines (diazepam), estrogen, progesterone, aminophylline (theophylline), tricyclic antidepressants, selective serotonin reuptake inhibitors, glucocorticosteroids; means providing a direct damaging effect on the esophageal mucosa, as well as lowering its resistance reflyuktatu, e.g., bisphosphonates, acetylsalicylic acid / non - steroidal anti - inflammatory agents, anticoagulants, antiplatelet drugs, iron preparations, ascorbic acid, potassium chloride, quinidine, phenytoin, calcium dobesilate, 131I sodium iodide, antibiotics (tetracycline, doxycycline, clindamycin, ciprofloxacin, ornidazole, clindamycin, rifampicin), antitumor agents; drugs that impede gastric emptying: calcium channel blockers, anticholinergics. These data can be used in practice in the choice of treatment tactics, especially in individuals with a diagnosis of gastroesophageal reflux disease or heartburn.
Patient's way from acute pulmonary embolism to chronic thromboembolic pulmonary hypertension: diagnostic and treatment options
Authors: Edemskiy A G , Ivanov S N , Kliver E N , Novikova N V , Galstyan M G , Sevastyanov A V , Cherniavsky A M
Published: September 2019

Сhronic thromboembolic pulmonary hypertension (CTEPH) is a serious, under - diagnosed but potentially curable complication of pulmonary embolism (PE) due to medicine advancements. Lack of specific symptoms and signs makes its diagnosis challenging, requiring clinicians to be ready to suspect its presence in patients with dyspnea of unknown origin or persistent symptoms after the pulmonary embolism event. The success of the treatment of this disease depends entirely on early diagnosis. The complexity of the differential diagnosis is due to the problematic aspects including the lack of doctors' awareness of both the pathology itself and the possibilities of its modern treatment. Recently, in our country, the problem of the availability of expert centers with sufficient experience in providing highly specialized medical care to this rather difficult category of patients who need specific therapy has become very actual. The aim of this review is to provide contemporary information about epidemiology, pathophysiology, and clinical features of treating patients with CTEPH, and also, to increase awareness of potential PE→CTEPH transformation. In the article a 4-year - period of experience of the Meshalkin National Medical Research Center on management of CTEPH patients has been presented.
Hypervitaminosis B12 - a new marker and predictor of prognostically unfavorable diseases
Authors: Podzolkov V I , Dragomiretskaya N A , Dambaeva O Ts , Auvinen S T , Medvedev I D
Published: September 2019

A high serum vitamin B12 level (hypercobalaminemia) is a underestimated anomaly. Clinically, it can be paradoxically accompanied by signs of deficiency, which are related to defects in tissue uptake of vitamin B12. The increase in the level of serum cobalamin occurs mainly in serious diseases that require early diagnosis: hemoblastosis, liver and kidney diseases, etc. This review presents data on the metabolism of vitamin B12 and the potential significance of increasing its level as a marker for the early diagnosis of these diseases.
Comparative clinical and economic evaluation of pharmacogenetic testing application for dabigatran in patients with atrial fibrillation
Authors: Abdullaev Sh P , Mirzaev K B , Sychev D A
Published: September 2019

Aim. To evaluate the clinical and economic feasibility of pharmacogenetic testing (PGT) for dabigataran etexilate administration in the treatment of atrial fibrillation (AF) without valve in comparison with tactics without pharmacogenetic testing. Materials and methods. The pharmacoeconomic model was done using generalized data from published clinical, epidemiological and clinical - economic studies. Results and discussion. Application of PGT on the carrier of allelic variant rs2244613 of CES1 gene for adjustment of dabigatrane etexilate dosage in patients with non - valve AF may be more cost - effective strategy for prevention of thromboembolic complications in patients with non - valve AF. Thus, due to the decrease in the number of undesirable drug reactions in the form of minor and major bleedings, the difference in treatment costs in the group with PGT compared to the group with standard pharmacotherapy tactics per 100 patients was 11 827.65 rubles. The expected cost per patient per year for standard treatment was 36 051.35 rubles, while in the group with PGT it was 35 933.07 rubles. The difference was 1182.76 rubles in favor of the pharmacogenetic approach Conclusion. A PGT approach to correct dabigatrane dosage can reduce the cost of pharmacotherapy by reducing the risk of adverse reactions of minor and major bleeding.
Methanobrevibacter smithii in irritable bowel syndrome: a clinical and molecular study
Authors: Vlasova A V , Isakov V A , Pilipenko V I , Sheveleva S A , Markova Yu M , Polyanina A S , Maev I V
Published: September 2019

Aim. To assess the role of Methanobrevibacter smithii in patients with irritable bowel syndrome associated with small intestinal bowel overgrowth. Materials and methods. Sixty - seven patients with IBS according to Rome IV were enrolled into the study in whom hydrogen breath test was performed. Thirty - two healthy subjects with negative breath test was used as a control. All IBS symptoms assessed daily with 5 grade Lykert scale for 7 days, stool was assessed by Brystol stool scale. M. smithii was confirmed in stool samples by PCR. Results and discussion. In 67 IBS patients CH4 overproduction was found in 32 (47.7%), H2 overproduction in 31 (46.2%) and normal values in 4 (5.9%) by hydrogen breath test. M. smithii was confirmed by stool PCR in all patients with CH4 overproduction. Severity and prevalence of main clinical features of IBS were similar in both SIBO groups but were significantly higher than in control (p
Treatment of candidemia caused by Candida albicans and Candida non - albicans in patients with hematological malignancies
Authors: Klyasova G A , Malchikova A O , Tandilova K S , Blohina E V , Parovichnikova E N , Kravchenko S K , Savchenko V G
Published: September 2019

Aim. To study the risk factors, symptoms and outcomes of candidemia caused by C. albicans and C. non - albicans in patients with hematological malignancies. Materials and methods. The study included patients with hematological malignancies and candidemia. The diagnosis of candidemia was established according to the single isolation of Candida spp. from blood culture and the presence of symptoms of infection. Results and discussion. Over 12 years (2006-2017), candidemia was diagnosed in 75 patients aged 17 to 77 years (median 48 years). The causative agents of candidemia were C. albicans in 34.7% of patients, C. non - albicans - in 65.3%. Candidemia caused by C. albicans prevailed in patients of the older age group (median 56.5 years, p=0.04) and in patients with lymphoma (61.5%, p=0.01) with colonization of the gut by the same species of Candida (88.5%, p=0.002). Isolation of C. non - albicans from blood culture was more common in patients with acute leukemia (51%, p=0.01) and in recipients of allogeneic hematopoietic stem cells (22.5%, p=0.01). The ability to form biofilms was observed more frequently among C. non - albicans (59.2%) than C. albicans (19.2%, p=0.001). The clinical symptoms of candidemia were non - specific (fever was in 97%). Septic shock developed in 25 (33%) patients with comparable frequency in both groups. Concomitant infections was also comparable (73% vs. 73.5%). Overall 30-day survival in patients with candidemia caused by C. albicans and C. non - albicans was 61.2% and 61.5%. Treatment with echinocandin was associated with increase of survival compared to other antifungal agents among patients with C. albicans candidaemia (88.9% versus 40%, p=0.02) and among C. non - albicans (77.3% versus 47.8%). Conclusion. C. non - albicans constituted a high proportion among causative agents of candidemia. High mortality rate was observed in both groups. Initial therapy with echinocandin was associated with increase of survival.
Current advances in the treatment of gastroesophageal reflux disease: a focus on esophageal protection
Authors: Maev I V , Andreev D N , Kucheryavyy Yu A , Shaburov R I
Published: September 2019

Gastroesophageal reflux disease (GERD) is characterized by high morbidity and a significant decrease in the quality of life of patients, and is a major risk factor for esophageal adenocarcinoma. Nowadays, antisecretory therapy with proton pump inhibitors (PPI) is the "gold standard" of conservative treatment of GERD, but in some cases this therapy is unsuccessful. According to various studies, the prevalence of refractory GERD can reach 30-40%. The latest scientific data in the field of genetics and pathophysiology of GERD demonstrate that a disruption of the barrier function of the esophageal mucosa and an increase of its permeability can be the leading causes of refractoriness. Thus, the optimal therapy for patients with GERD should not only suppress the secretion of hydrochloric acid, but also restore the barrier function of the mucous membrane, providing an esophagoprotective effect. To achieve these goals, Alfasoxx was developed, which consists of a mixture of low molecular weight hyaluronic acid and low molecular weight chondroitin sulfate dissolved in a bioadhesive carrier (poloxamer 407). The clinical efficacy of this product has been confirmed by three prospective, randomized, placebo - controlled trials. Alfasoxx has a healing and restorative effect towards the esophageal epithelium and due to high ability for bioadhesion provides long - term protection of the mucous membrane of the esophagus. Combination therapy for GERD with the use of PPI and an esophagoprotector offers new perspectives for the treatment of patients with GERD.
Micro-RNA as a new biomarker of activity of the cytochrome system P-450: significance for predicting the antiplatelet action of P2Y12 receptor inhibitors
Authors: Rytkin E I , Mirzaev K B , Bure I V , Sychev D A
Published: September 2019

MicroRNAs are short non - coding RNAs that correlate with the levels of platelet activation which can be utilized as a biomarker when guiding P2Y12 inhibitors therapy. In this literature review, the perspectives of microRNA as a novel biomarker are discussed when guiding P2Y12 inhibitors therapy among the patients with coronary artery disease.
Some practical issues in the management of patients with decompensated liver cirrhosis
Authors: Fedosina E A , Byeverov A O , Bogomolov P O , Staroverova N P
Published: September 2019

The natural course of cirrhosis is characterized by a shift from a compensated stage without clinical manifestations to a subsequent decompensated stage, which is characterized by the development of obvious clinical symptoms, the most frequent of which are ascites, bleeding from varicose veins, bacterial infections, encephalopathy. The articles and reviews of recent years emphasize the importance of etiotropic treatment of liver cirrhosis at any stage, including the final one. In addition, pathogenetic and symptomatic therapy aimed at treating complications of cirrhosis of the liver: ascites, dilution hyponatremia, gastrointestinal bleeding, bacterial infections, and kidney damage comes to the forefront at the stage of decompensation, which allows the patient to be on the waiting list for liver transplantation. This category of patients, as a rule, is difficult to treat and has features and subtleties of reference.
New directions of pharmacotherapy of immune - inflammatory rheumatic diseases
Authors: Nasonov E L
Published: September 2019

Deciphering immunopathogenesis, expanding the scope of diagnostics and developing new methods for treating human autoimmune diseases are among the priority areas of XXI century medicine. Particularly widely autoimmune pathology is presented in immunoinflammatory rheumatic diseases (IIRD), such as rheumatoid arthritis, systemic lupus erythematosus, systemic scleroderma, systemic vasculitis associated with the synthesis of antineutrophilic cytoplasmic antibodies, Sjogren's syndrome, idiopathic inflammatory myopathies and other other types of others. Deciphering the pathogenesis mechanisms of IIRD created the prerequisites for improving pharmacotherapy, which in the future should lead to a dramatic improvement in the prognosis for these diseases. The review discusses new approaches to IIRD pharmacotherapy associated with the inhibition of tumor necrosis factor-α, interleukin-6 (IL-6), IL-1β, IL-17, IL-23, and the prospects for using Janus kinase inhibitors, depending on the prevailing pathogenesis mechanisms - autoimmunity or autoinflammation.
Study of the effect of pvp k30 in the enhancement of solubility of telmisartan by polymer assisted crystal agglomeration using polymer enriched bridging liquid technique
Authors: Manoj K  , Seenivasan P  , Arul K  , Senthil kumar M
Published: September 2019

Polymer Enriched Bridging liquid is a novel approach for enhancing the flow characteristics, properties, solubility and dissolution of poorly water-soluble drugs. is an orally effective II receptor antagonist used extensively for the effective management of hypertension. is a poorly water-soluble drug and an ideal candidate for this approach. PVPK30 is used as the hydrophilic polymer. Various formulations were prepared with the addition of PVPK30 in the bridging liquid by Polymer Enriched Bridging Liquid Technique (PEBL). The preparations were subjected to particle size analysis, characteristics, FTIR, differential scanning (DSC) and Scanning Electron microscopic analysis. The crystal agglomerates were found to be spherical in nature with excellent flow characteristics. The of the pure drug was found to be decreased without any drug-polymer interaction. The saturation solubility studies showed that the optimized formulation STP04 showed 30.695 folds increase in solubility in water and 29.462 folds enhancement in pH 7.5 phosphate buffer. The in drug release studies also confirmed the enhancement in dissolution rate. The stability of the prepared aggregates was determined by accelerated stability studies. The addition of polymer in the bridging liquid during crystallization stage improved the effective incorporation of the hydrophilic polymer in the aggregates. Polymer Enriched Bridging Liquid technique can be considered as an ideal technique for solubility and dissolution enhancement.
新零售与同城配双系统融合影响因素分析
Authors: 裘 伟超 , 叶 芬芳
Published: September 2019

在新零售的发展势头下，同城配也成了新晋“网红”，两者之间能否形成良性融合发展，一方面通过技术创新，借助大数据等提升同城配效率，一方面通过同城配提高线下服务标准，以提升客户服务品质，显得尤为重要。本文通过分析双系统融合的主要影响因素，提出新零售与同城配双系统融合发展的建议，以期能促进新零售业与同城配送的共同发展。
基于熵权法的经济与生态环境协调发展研究——以中国部分省份为例
Authors: 刘 洪亳 , 范 乔希 , 梅 若冰
Published: September 2019

随着经济的快速发展，资源枯竭、生态失调、环境恶化等一系列矛盾凸显，为促进经济和生态环境协调发展，实现生态文明建设迫在眉睫。本文通过构建经济与环境协调度评价指标体系，运用熵权法计算经济指标综合指数和环境指标综合指数，构建耦合度模型，研究选取中国 6 个省份经济与环境的协调发展程度，分析影响协调度的主要因素。结果表明，6 个省份在2007-2016 这十年间经济与生态环境之间的协调程度逐渐好转，浙江省和湖南省总体情况较好；河北省和黑龙江省受环境问题影响协调程度；内蒙古自治区和云南省受经济发展问题影响协调程度。
“华龙一号”ZH-65型蒸汽发生器关键制造工艺及质量控制
Authors: 田 清
Published: September 2019

“华龙一号”是中国自主设计的三代压水堆核电技术，具有完全自主知识产权。蒸汽发生器是“华龙一号”核电机组反应堆冷却剂系统关键设备，型号为 ZH-65，其安全级别高、质保等级高，而且结构复杂、制造工艺难度大。本文结合工程经验，介绍了“华龙一号”蒸汽发生器的关键制造工艺及质量控制要点，为核电蒸汽发生器及其它主设备制造工艺优化、产品质量提升提供经验借鉴。
建筑暖通施工技术中的问题和对策
Authors: 李 飞
Published: September 2019

随着中国建筑工程行业不断发展，建筑工程项目可以更适用于人们生存和发展的需要，有效改善人们的生存环境。建筑暖通工程项目作为建筑工程的主要组成部分，直接影响建筑工程的建设水平和环境质量，关系着建筑工程项目是否能够顺利竣工。但从实际建筑暖通施工过程来看，由于施工环节较多，施工技术含量较高，影响因素多样，导致施工过程中不可避免地会遇到各种各样的问题，而影响建筑暖通工程施工效率和施工质量。因此，必须要根据当前建筑暖通施工技术应用现状，采取有效措施提高暖通工程施工水平。
浅析电厂信息系统安全风险及对策
Authors: 杨 燕 , 于 爱民
Published: September 2019

随着中国电厂侧信息技术应用的不断深化，发电企业对信息系统和网络的依赖程度越来越高，信息安全的重要性显得愈加重要，这也对电厂侧的信息安全和信息专业人员提出了更高的要求。本文对电厂信息系统存在的安全风险和对策进行了分析，旨在为电厂从事信息工作的人员提供参考。
高炉顶压前馈PID复合控制系统的应用
Authors: 刘 金花 , 刘 志波
Published: September 2019

针对湖南华菱涟钢 3200m3 高炉炉顶压力一直在 ± 5kPa 内波动且在短时间内不能趋于稳定，从高炉工艺方面分析影响高炉炉顶压力波动的主要因素为炉顶布料和料罐均压，通过对布料过程中料面流量的变化分析建立了布料前馈模型；通过对料罐均压过程分析，建立了料罐均压前馈模型，设计了一套高炉顶压 PID 前馈复合控制算法，达到稳定炉顶压力的目的。现场运行效果表明本文设计的 TRT 高炉顶压前馈 PID 复合控制较现有 PID 控制能明显改善炉顶压力的稳态精度与抗干扰能力，控制精度提高到 ± 3KPa，并为其他高炉炉顶压力控制提供了指导作用。
输入输出层选取对GPS高程转换影响
Authors: 王 伟 , 吴 海兵
Published: September 2019

利用神经网络转换 GPS 高程来精化区域似大地水准面需要选择合理的输入输出层，本文论述了如何设计输入输出层，并在基于不同的输入输出层基础上运用标准 BP 神经网络模型、GRNN 神经网络模型和 RBF 神经网络模型进行运算，将转换结果进行对比，得出不同的输入输出层会对 GPS 高程转换结果产生一定的影响，并对实际应用中输入输出层的选择提出合理的意见。
低温余热除盐水系统优化的节能改造措施
Authors: 张 子峥
Published: September 2019

本文介绍了中国南方某炼油厂低低压蒸汽管网及低温余热系统运行现状，针对低低压蒸汽放空问题，分析与探讨蒸汽回收方案，提出低温余热系统节能即除盐水预热系统改造措施，合理优化热源与热阱的匹配。该项目实施后，除盐水预热系统热源分布进一步优化，全部回收放空的低低压蒸汽，同时减少高品位蒸汽的消耗，具有良好的节能与经济效益。
Gambaran Monitoring Gula Darah Kasus Diabetes Melitus di Puskesmas ‘X’ Kota Dumai
Authors: Nazriati Elda , Chandra Fifia , Izfhathaniah Izfhathaniah
Published: September 2019

Diabetes mellitus is a metabolic disease that has 2 main targets of treatment, keeping the glucose levels within normalrange, and preventing complications. The purposed of this research is to know the description of blood glucosemonitoring consisting of fasting blood glucose, HbA1C, and self monitoring blood glucose (SMBG). This was aqualitative research by using observation method and deep interview to ten informant. The results showed thecheckup of fasting blood glucose levels have been going well with some obstacles, for instance, running out ofglucose strips. Puskesmas ‘X’ did not perform HbA1C checkup due to unavailability of laboratory equipment. OverallDM patients did not perform SMBG because they did not have the device, but the researchers obtained one patientwho had a device at home, but the patient still chose to check his blood glucose at the puskesmas because the lowknowledge of the patient to perform SMBG.
Gambaran Sarapan dan Status Gizi Pada Mahasiswa Fakultas Kedokteran Universitas Riau Angkatan 2017
Authors: Kurniyanti Isnani , Christianto Erwin , Ismawati Ismawati
Published: September 2019

Breakfast is an activity of eating and drinking between waking up to 9 am to fulfill some of the daily nutritional needs(15-30% nutritional needs). The benefits of breakfast are maintaining an ideal body weight because breakfast canreduce the amount of food you eat throughout the day. The purpose of this study was to find out the description ofbreakfast and Body Mass Index (BMI) in students of the Faculty of Medicine, University of Riau in 2017. This researchwas descriptive study with 121 samples. The results showed 16.3% obese I and 8.1% obese II. Respondents with goodbreakfast calories tend to have good nutritional status of 50.0%.
Hubungan Learning Approach Dengan Nilai Objective Structured Clinical Examination (OSCE) Mahasiswa Fakultas Kedokteran Universitas Riau Tahun Kedua
Authors: Rantari Zulfi Mustika , Zulharman Zulharman , Asni Enikarmila
Published: September 2019

The learning approach is the way to achieve their learning objectives. Learning approach can influence the OSCEvalue. This study aimed to analyze the relationship between learning approach and OSCE value. This study wasanalytic descriptive with cross-sectional design. The subjects were all the medical student University of Riau in thesecond year. Study Process Questionnaire (SPQ) which have been translated to Indonesia language was used in thisstudy. OSCE value before remedial data were analyzed using Kruskal-Wallis. The majority of students (93.1%) usingthe achieving approach and there were no relationship between learning approach and OSCE value. lue.
Talaromikosis Marneffei
Authors: Surja Sem S. , Adawiyah Robiatul , Wahyuningsih Retno
Published: September 2019

Talaromycosis marneffei is a mycotic disease caused by Talaromyces marneffei which primarily infectimmunocompromised patient. This disease is endemic in Southeast Asia, and Indonesia consider as endemic area dueto a case of tourist who got the infection after visiting Indonesia. Diagnosis was made based on clinical suspicion withlaboratory confirmation. Clinical manifestations are not specific, such as fever, anemia, weight loss, lymphadenopathy,hepatomegaly, splenomegaly, respiratory disorder, and cutaneous manifestation. Histopathology and culture are themost common examination performed for diagnosis. In histopathology examination, fungi appear as fission arthroconidiacells which shape round to oval, with cross wall formation inside or outside macrophage and histiocyte. Thermaldimorphism characteristic can be observed in fungal culture. Fungi grows as mold at 25oC-30oC and as yeast at 37oC.Definitive identification of T. marneffei was done by molecular examination using primers derived from ITS region asprimary marker and beta tubulin region as secondary marker. Talaromyces marneffei is sapronosis, that transmitted viainhalation of conidia from environment.
Hubungan Kejadian Kondiloma Akuminata Terhadap Kualitas Hidup Pekerja Seks Komersial di Hotspot Pekanbaru
Authors: Maharani Puteri , Amtarina Rina , Widiawaty Alida
Published: September 2019

Genital Warts (GW) is one of the most common clinical manifestations of human papillomavirus (HPV) infection. GWpatients experience discomfort and anxiety about the effects of illness that will affect their quality of life (QOL). Thepurpose of this study was to analyze the relationship between GW and QOL of Female Sex-Workers (FSW) in hotspotX of Pekanbaru which involved 49 FSW by using total sampling technique. The QOL data was taken by usingWHOQOL-BREF questionnaire that consists of physical, psychological, social, and enviromental score. whereas theGW data from physical examination. Data were analyzed by using t-test and Mann Whitney. The t-test showed theresult of psychological score (p=0,000), environmental score (p=0,463). The Mann-Whitney test showed the resultphysical score (p=0,007), social score (p=0,019). It could be concluded that there was a relationship between GW withphysical, psychological, and social scores, but no relationship with environmental score.
Identifikasi Tungau Debu Rumah di Tempat Tinggal Pasien Dermatitis Atopik RSUD Petala Bumi Pekanbaru
Authors: Lesmana Suri Dwi , Putra Deon Pradana , Widiawaty Alida
Published: September 2019

House dust mite have an important role as an allergens in allergic diseases such as atopic dermatitis. Atopic dermatitisis inflammation of the skin with itching, chronic and recurrent symptoms. The aim of this study was to find out thedescription of house dust mites in the house of patients at Petala Bumi Hospital. Design of study was a crosssectional.This study was occured from May-June 2018 in the Laboratory of Parasitology and involved 30 atopicdermatitis patients with consecutive sampling technique. Results is showed 100% of atopic dermatitis patients housewere positive for house dust mites, 63.3% of patients behaved badly in hygiene which affected degree of house dustmite spread. Conclusions of this study showed that a whole place of atopic dermatitis patients house was positive forhouse dust mite, most of patients behaved badly in hygiene which affected degree of house dust mite spread.