bluuebunny/crossref_metadata_2025 huggingface dataset:
Improvement of Salinity Tolerance in Water-Saving and Drought-Resistance Rice (WDR)
Authors: Liu Yi , Wang Feiming , Zhang Anning , Chen Zhihao , Luo Xingxing , Kong Deyan , Zhang Fenyun , Yu Xinqiao , Liu Guolan , Luo Lijun
Published: March 2023

Rice is one of the most economically important staple food crops in the world. Soil salinization and drought seriously restrict sustainable rice production. Drought aggravates the degree of soil salinization, and, at the same time, increased soil salinity also inhibits water absorption, resulting in physiological drought stress. Salt tolerance in rice is a complex quantitative trait controlled by multiple genes. This review presents and discusses the recent research developments on salt stress impact on rice growth, rice salt tolerance mechanisms, the identification and selection of salt-tolerant rice resources, and strategies to improve rice salt tolerance. In recent years, the increased cultivation of water-saving and drought-resistance rice (WDR) has shown great application potential in alleviating the water resource crisis and ensuring food and ecological security. Here, we present an innovative germplasm selection strategy of salt-tolerant WDR, using a population that is developed by recurrent selection based on dominant genic male sterility. We aim to provide a reference for efficient genetic improvement and germplasm innovation of complex traits (drought and salt tolerance) that can be translated into breeding all economically important cereal crops.
Potential Anti-Candida albicans Mechanism of Trichoderma Acid from Trichoderma spirale
Authors: Ye Wei , Chen Yuchan , Zhang Weimin , Liu Taomei , Liu Yuping , Li Mengran , Li Saini , Xu Liqiong , Liu Hongxin
Published: March 2023

Candida albicans is the main causal pathogen of fungal infections in human beings. Although diverse anti-C. albicans drugs have been explored, the drug resistance and side effects of these drugs are intensifying. Thus, it is urgent to explore new anti-C. albicans compounds from natural products. In this study, we identified trichoderma acid (TA), a compound from Trichoderma spirale with a strong inhibitory effect on C. albicans. Transcriptomic and iTRAQ-based proteomic analyses of TA-treated C. albicans in combination with scanning electronic microscopy and reactive oxygen species (ROS) detection were performed to investigate the potential targets of TA. The most significant differentially expressed genes and proteins after TA treatment were verified through Western blot analysis. Our results revealed that mitochondrial membrane potential, endoplasmic reticulum, ribosomes in the mitochondria, and cell walls were disrupted in TA-treated C. albicans, leading to the accumulation of ROS. The impaired enzymatic activities of superoxide dismutase further contributed to the increase in ROS concentration. The high concentration of ROS led to DNA damage and cell skeleton destruction. The expression levels of Rho-related GTP-binding protein RhoE (RND3), asparagine synthetase (ASNS), glutathione S-transferase, and heat shock protein 70 were significantly up-regulated in response to apoptosis and toxin stimulation. These findings suggest that RND3, ASNS, and supereoxide dismutase 5 are the potential targets of TA, as further demonstrated through Western blot analysis. The combination of transcriptomic, proteomic, and cellular analyses would provide clues for the anti-C. albicans mechanism of TA and the defensive response mechanism of C. albicans. TA is thus recognized as a promising new anti-C. albicans leading compound that alleviates the hazard of C. albicans infection in human beings.
Purinergic P2 Receptors: Structure and Function 2.0
Authors: Zemkova Hana
Published: March 2023

This Special Issue of the International Journal of Molecular Sciences (IJMS) is a direct continuation of the previous Special Issue of this journal, entitled “Purinergic P2 Receptors: Structure and Function” https://www [...]
Microarrays, Enzymatic Assays, and MALDI-MS for Determining Specific Alterations to Mitochondrial Electron Transport Chain Activity, ROS Formation, and Lipid Composition in a Monkey Model of Parkinson’s Disease
Authors: García-Fernández María Dolores , Larrea Ane , Fernández Roberto , Rodríguez-Puertas Rafael , Astigarraga Egoitz , Manuel Iván , Barreda-Gómez Gabriel
Published: March 2023

Multiple evidences suggest that mitochondrial dysfunction is implicated in the pathogenesis of Parkinson’s disease via the selective cell death of dopaminergic neurons, such as that which occurs after prolonged exposure to the mitochondrial electron transport chain (ETC) complex I inhibitor, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrine (MPTP). However, the effects of chronic MPTP on the ETC complexes and on enzymes of lipid metabolism have not yet been thoroughly determined. To face these questions, the enzymatic activities of ETC complexes and the lipidomic profile of MPTP-treated non-human primate samples were determined using cell membrane microarrays from different brain areas and tissues. MPTP treatment induced an increase in complex II activity in the olfactory bulb, putamen, caudate, and substantia nigra, where a decrease in complex IV activity was observed. The lipidomic profile was also altered in these areas, with a reduction in the phosphatidylserine (38:1) content being especially relevant. Thus, MPTP treatment not only modulates ETC enzymes, but also seems to alter other mitochondrial enzymes that regulate the lipid metabolism. Moreover, these results show that a combination of cell membrane microarrays, enzymatic assays, and MALDI-MS provides a powerful tool for identifying and validating new therapeutic targets that might accelerate the drug discovery process.
Quo Vadis Business Simulation Games in the 21st Century?
Authors: Bach Mirjana Pejić , Ćurlin Tamara , Stjepić Ana Marija , Meško Maja
Published: March 2023

Business simulation games have become popular in higher education and business environments. The paper aims to identify the primary research trends and topics of business simulation games research using a systematic and automated literature review with the motivation of research (learning driven and domain driven). Based on these findings, the future development of business simulation games research projected papers that research business simulation games were extracted from Scopus. Second, the research timeline, main publication venues and citation trends have been analysed. Third, the most frequent words, phrases, and topics were extracted using text mining. Results indicate that the research on business simulation games has stagnated, with the most cited papers published in the 2000s. There is a balance between learning-driven and domain driven-research, while technology-driven research is scarce, indicating that the technology used for business simulation games is mature. We project that the research on business simulation games needs to be directed in the area of new technologies that could improve communication with and among the users (virtual reality, augmented reality, simulation games) and technologies that could improve the reasoning and decision-making complexity in business simulation games (artificial intelligence).
Factors Guiding the Orientation of Nymphal Spotted Lanternfly, Lycorma delicatula
Authors: Cooperband Miriam F. , Wickham Jacob D. , Warden Melissa L.
Published: March 2023

A mark–release–recapture experiment was conducted to evaluate the orientation of spotted lanternfly (SLF) Lycorma delicatula White (Hemiptera: Fulgoridae) nymphs when released equidistant between two trees. The experiment was repeated weekly for eight weeks in a heavily infested area with mature tree-of-heaven Ailanthus altissima (Mill.) Swingle (Sapindales: Simaroubaceae) planted in rows as ornamental street trees in Beijing, China. One tree in each pair received a methyl salicylate lure, and the lure was rotated between trees every week as it aged. Two additional independent variables for each tree were also analyzed: size and SLF population density. Marked–released SLF significantly chose trees with higher SLF population density over trees with lower density populations, and they also chose larger trees significantly more than smaller trees. Population density and tree size were better predictors of attraction than lures, but when those factors were controlled, SLF significantly chose trees with methyl salicylate lures over control trees for the first 4 weeks of lure life. Wild SLF distribution was assessed weekly, revealing strong aggregation in first and second instars that diminished with development to the third and fourth instars. Thus, nymphal SLF aggregate, and orientation is strongly guided by the presence of other SLF and tree size.
Dermal Substitutes and Skin Grafts in the Reconstruction of Post-Traumatic Total Scalp Avulsion: A Case Series
Authors: Petrocelli Marzia , Togo Giulia , Ricci Silvia , Zeneli Flavia , Cutrupi Sebastiano , Baietti Annamaria , Bonavolontà Paola , Califano Luigi , Vaira Luigi , Scarpa Alfonso , Di Stadio Arianna , Salzano Giovanni
Published: March 2023

Although scalp defects can vary in size and thickness, scalp avulsion represents a rare occurrence. This type of lesion may have different origins, but it is usually related to long hair being caught in agricultural machinery. The management of full-thickness scalp defects poses a challenge to the head and neck surgeon due to the possible involvement of neurovascular structures and scar retraction, which can affect the esthetic restoration of the area. Several algorithms for the choice of scalp reconstruction have been proposed in the literature and different techniques are available for extensive scalp defect reconstruction (local soft tissue flap, microvascular free flap, and skin graft combined with dermal substitutes), based upon the scalp defect type. Here we describe six cases of patients with total scalp avulsion, which required a combined reconstruction with a split-thickness skin graft (STSG) and Integra® matrix immediately after the trauma.
Perioperative Complications after Hip and Knee Revision Arthroplasty in the over 80 Years Old Population: A Retrospective Observational Case–Control Study
Authors: Di Matteo Vincenzo , Di Pilla Marina , La Camera Francesco , Morenghi Emanuela , Grappiolo Guido , Loppini Mattia
Published: March 2023

Background: The number of joint revision arthroplasties has increased in the elderly population, which is burdened by several perioperative risks. Methods: Patients who underwent hip and knee revision arthroplasty were retrospectively included, and they were divided into two groups by age: <80 years old (Group 1) and ≥80 years old (Group 2). The primary outcome was to compare perioperative complication rates. The secondary outcome was to compare the 30-day, 90-day, and 1-year readmission rates. Results: In total, 74 patients in Group 1 and 75 patients in Group 2 were included. Postoperative anemia affected 13 patients in Group 1 (17.6%) and 25 in Group 2 (33.3%, p 0.027); blood units were transfused in 20 (26.7%) and 11 (14.9%, p 0.076) patients, respectively. In Group 1, two (2.7%) patients reported wound infection. In Group 2, eight (10.7%) patients presented hematomas, and two (2.7%) patients reported dislocations. No significant differences in the two groups were observed for 30-day (p 0.208), 90-day (p 0.273), or 1-year readmission rates (p 0.784). Conclusion: The revision arthroplasty procedure in patients over 80 years old is not associated with a higher risk of perioperative complications, or higher readmission rate compared with younger patients undergoing hip and knee revision surgery.
Epicardial Adipose Tissue: A Piece of The Puzzle in Pediatric Hypertension
Authors: Schweighofer Nina , Rupreht Mitja , Marčun Varda Nataša , Caf Primož , Povalej Bržan Petra , Kanič Vojko
Published: March 2023

Background and purpose: Epicardial adipose tissue (EAT) is a metabolically active tissue located on the surface of the myocardium, which might have a potential impact on cardiac function and morphology. The aim of this study was to evaluate whether EAT is associated with essential arterial hypertension (AH) in children and adolescents. Methods: Prospective cardiovascular magnetic resonance (CMR) study and clinical evaluation were performed on 72 children, 36 of whom were diagnosed with essential AH, and the other 36 were healthy controls. The two groups were compared in volume and thickness of EAT, end-diastolic volume, end-systolic volume, stroke volume, left ventricular (LV) ejection fraction, average heart mass, average LV myocardial thickness, peak filling rate, peak filling time and clinical parameters. Results: Hypertensive patients have a higher volume (16.5 ± 1.9 cm3 and 10.9 ± 1.5 cm3 (t = −13.815, p < 0.001)) and thickness (0.8 ± 0.3 cm and 0.4 ± 0.1 cm, (U = 65.5, p < 0.001)) of EAT compared to their healthy peers. The volume of EAT might be a potential predictor of AH in children. Conclusions: Our study indicates that the volume of EAT is closely associated with hypertension in children and adolescents.
Construction and Validation of an Image Discrimination Algorithm to Discriminate Necrosis from Wounds in Pressure Ulcers
Authors: Sakakibara Shunsuke , Takekawa Akira , Takekawa Chikara , Nagai Satoshi , Terashi Hiroto
Published: March 2023

Artificial intelligence (AI) in medical care can raise diagnosis accuracy and improve its uniformity. This study developed a diagnostic imaging system for chronic wounds that can be used in medically underpopulated areas. The image identification algorithm searches for patterns and makes decisions based on information obtained from pixels rather than images. Images of 50 patients with pressure sores treated at Kobe University Hospital were examined. The algorithm determined the presence of necrosis with a significant difference (p = 3.39 × 10−5). A threshold value was created with a luminance difference of 50 for the group with necrosis of 5% or more black pixels. In the no-necrosis group with less than 5% black pixels, the threshold value was created with a brightness difference of 100. The “shallow wounds” were distributed below 100, whereas the “deep wounds” were distributed above 100. When the algorithm was applied to 24 images of 23 new cases, there was 100% agreement between the specialist and the algorithm regarding the presence of necrotic tissue and wound depth evaluation. The algorithm identifies the necrotic tissue and wound depth without requiring a large amount of data, making it suitable for application to future AI diagnosis systems for chronic wounds.
The Impact of Depression and Anxiety on Adult Cancer Patients’ Health-Related Quality of Life
Authors: Alwhaibi Monira , AlRuthia Yazed , Sales Ibrahim
Published: March 2023

Background: Cancer patients are at high risk for mental illness and, in turn, poorer health-related quality of life. This study used nationally representative United States (US) data to examine nuances of the impact of depression and/or anxiety on HRQoL in different cancer groups (e.g., cancer only, cancer and depression, cancer and anxiety, cancer and both conditions). Methods: Adult patients aged 18 years and older with a cancer diagnosis were identified from the Medical Expenditure Panel Survey data for 2012–2016. HRQoL was measured using the SF-12 Physical and Mental Component Summary (PCS & MCS) scores. Multivariate linear regressions were used, controlling for a multitude of factors. Results: Around 12% of the 1712 identified patients with cancer had depression, 13% had anxiety, and 8.4% had both depression and anxiety. Patients with comorbid depression and anxiety had the lowest mean scores of both PCS and MCS compared to patients in other groups. In addition, cancer patients with either depression and/or anxiety were more likely to have lower MCS scores compared to those with cancer only (depression: β = −6.554; anxiety: β = −3.916; both conditions: β = −11.759, p < 0.001). Interestingly, patients with comorbid depression and anxiety were more likely to have higher PCS scores compared to those with cancer only. Conclusions: The psychological burden of cancer is immense, with a substantial impact on patients’ HRQoL. Routine screening for depression and anxiety, especially for women and those with low poverty status and comorbidities, should be conducted by healthcare providers to identify those with high odds of having a lower HRQoL. Additionally, early psychiatric interventions, such as psychotherapy and prescription drugs, may positively impact patients’ mental well-being and HRQoL.
Goniotomy for Non-Infectious Uveitic Glaucoma in Children
Authors: Meerwijk Charlotte L. L. I. van , Edema Astrid B. , Rijn Laurentius J. van , Los Leonoor I. , Jansonius Nomdo M.
Published: March 2023

Secondary glaucoma is still a blinding complication in childhood uveitis, for which most commonly used surgical interventions (trabeculectomy or glaucoma drainage implant) involve multiple re-interventions and/or complications postoperatively. The goniotomy procedure has never been investigated in the current era, in which patients with pediatric uveitis receive biologics as immunosuppressive therapy for a prolonged period, with potential implications for the outcome. The purpose of the study is to evaluate the efficacy and safety of a goniotomy procedure in pediatric non-infectious uveitis in a retrospective, multicenter case series. The primary outcomes were the postoperative intraocular pressure (IOP), number of IOP-lowering medications, and success rate. Postoperative success was defined as 6 ≤ IOP ≤ 21 mmHg, without major complications or re-interventions. Fifteen eyes of ten children were included. Median age of the included patients at goniotomy was 7 years; median follow-up was 59 months. Median (interquartile range) IOP before surgery was 30 (26–34) mmHg with 4 (3–4) IOP-lowering medications. At 1, 2, and 5 years after goniotomy, median IOP was 15, 14, and 15 mmHg with 2 (0–2), 1 (0–2), and 0 (0–2) medications, respectively (p < 0.001 postoperatively versus preoperatively for all timepoints). Success rate was 100%, 93%, and 80% after 1, 2, and 5 years, respectively. There were no significant changes in visual acuity and uveitis activity or its treatment, and there were no major complications. Our results show that the goniotomy is an effective and safe surgery for children with uveitic glaucoma.
Clinical Predictors and Prediction Models for rFVIII-Fc Half Life in Real-World People with Severe Hemophilia A
Authors: Chang Chia-Yau , Chiou Shyh-Shin , Weng Te-Fu , Lin Pei-Chin , Lai Shiue-Wei , Tsai Chen-Hua , Liu Yen-Lin , Ku Jung-Tzu , Liao Yu-Mei , Tsai Jia-Ruey , Hu Shu-Hsia , Cheng Chao-Neng , Chen Yeu-Chin
Published: March 2023

The half life of recombinant factor VIII-Fc (rFVIII-Fc) for people with hemophilia A (PwHA) varies greatly. Understanding the factors influencing the variation and assessment of rFVIII-Fc half life is important for personalized treatment. Eighty-five severe-type PwHA with rFVIII-Fc treatment receiving an evaluation of half life by the Web-Accessible Population Pharmacokinetic (PK) Service—Hemophilia during 2019–2021 were retrospectively enrolled. The 50-patient PK profiles before 2021 were used for analysis and developing prediction models of half life, and the 35-patient PK profiles in 2021 were used for external validation. The patients in the development cohort were aged 8–64, with a median rFVIII-Fc half life of 20.75 h (range, 8.25–41.5 h). By multivariate linear regression analysis, we found two, four, and five predictors of rFVIII-Fc half life for the blood groups non-O, O patients, and overall patients, respectively, including baseline VWF:Ag, BMI, VWF:activity/VWF:Ag ratio, body weight, O blood group, inhibitor history, HCV infection, and hematocrit. The three prediction equations of rFVIII-Fc half life (T) were respectively developed as T for non-O group patients = −0.81 + 0.63 × (BMI, kg/m2) + 6.07 × (baseline VWF:Ag, IU/mL), T for O group patients = −0.68 + 13.30 × (baseline VWF:Ag, IU/mL) + 0.27 × (BW, kg) − 1.17 × (BMI, kg/m2) + 16.02 × (VWF:activity/VWF:Ag ratio), and T for overall patients = −1.76 + 7.24 × (baseline VWF:Ag, IU/mL) − 3.84 × (Inhibitor history) + 2.99 × (HCV infection) − 2.83 × (O blood group) + 0.30 × (Hct, %), which explained 51.97%, 75.17%, and 66.38% of the half life variability, respectively. For external validation, there was a significant correlation between the predicted and observed half lives in the validation cohort. The median half life deviation was +1.53 h, +1.28 h, and +1.79 h for the equations of non-O group, O group, and overall group patients, respectively. In total, eight predictors influencing rFVIII-Fc half life were identified. Prediction equations of rFVIII-Fc half life were developed for the non-O and O blood groups and overall PwHA with a good degree of external validation. The equations could be applied to patients aged 8–64 without the need for PK blood sampling and clinically valuable for personalized therapy.
Survey of Edible Amanita in Northern Thailand and Their Nutritional Value, Total Phenolic Content, Antioxidant and α-Glucosidase Inhibitory Activities
Authors: Kumla Jaturong , Suwannarach Nakarin , Liu Yuan S. , Tanruean Keerati , Lumyong Saisamorn
Published: March 2023

Edible wild mushrooms are extremely popular among consumers and are highly valued for their potential economic benefits in northern Thailand. In this present study, a total of 19 specimens of edible Amanita were collected during investigations of wild edible mushrooms in northern Thailand during the period from 2019 to 2022. Their morphological characteristics and the phylogenetic analyses of the internal transcribed spacer (ITS) and partial large subunit (nrLSU) of ribosomal RNA, RNA polymerase II second-largest subunit (rpb2) and partial translation elongation factor 1-alpha (tef-1) indicated that the collected specimens belonged to A. hemibapha, A. pseudoprinceps, A. rubromarginata, A. subhemibapha, and Amanita section Caesareae. This is the first report of A. pseudoprinceps and A. subhemibapha from Thailand. Full descriptions, illustrations and a phylogenetic placement of all specimens collected in this study are provided. Subsequently, the nutritional composition and total phenolic content, as well as the antioxidant and α-glucosidase inhibitory activities, of each species were investigated. The results indicate that the protein contents in both A. pseudoprinceps and A. subhemibapha were significantly higher than in A. hemibapha and A. rubromarginata. The highest total phenolic content was found in the extract of A. pseudoprinceps. In terms of antioxidant properties, the extract of A. pseudoprinceps also exhibited significantly high antioxidant activity by 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. However, the extract of A. rubromarginata had the lowest total phenolic content and level of antioxidant activity. Additionally, α-glucosidase inhibitory activity varied for different Amanita species and the highest level of α-glucosidase inhibitory activity was found in the extract of A. pseudoprinceps. This study provides valuable information on the nutrient content, phenolic content and the antioxidant and α-glucosidase inhibitory potential of edible Amanita species found in northern Thailand.
Combating the Dust Devil: Utilizing Naturally Occurring Soil Microbes in Arizona to Inhibit the Growth of Coccidioides spp., the Causative Agent of Valley Fever
Authors: Kollath Daniel R. , Morales Matthew M. , Itogawa Ashley N. , Mullaney Dustin , Lee Naomi R. , Barker Bridget M.
Published: March 2023

The fungal disease Valley fever causes a significant medical and financial burden for affected people in the endemic region, and this burden is on the rise. Despite the medical importance of this disease, little is known about ecological factors that influence the geographic point sources of high abundance of the pathogens Coccidioides posadasii and C. immitis, such as competition with co-occurring soil microbes. These “hot spots”, for instance, those in southern Arizona, are areas in which humans are at greater risk of being infected with the fungus due to consistent exposure. The aim of this study was to isolate native microbes from soils collected from Tucson, Arizona (endemic area for C. posadasii) and characterize their relationship (antagonistic, synergistic, or neutral) to the fungal pathogen with in vitro challenge assays. Secreted metabolites from the microbes were extracted and described using analytical techniques including high-performance liquid chromatography (HPLC) and mass spectrometry. Bacteria belonging to the genus Bacillus and fungi in the Fennellomyces and Ovatospora genera were shown to significantly decrease the growth of Coccidioides spp. In vitro. In contrast, other bacteria in the Brevibacillus genus, as well as one species of Bacillus bacteria, were shown to promote growth of Coccidioides when directly challenged. The metabolites secreted from the antagonistic bacteria were described using HPLC and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The microbes identified in this study as antagonists to Coccidioides and/or the metabolites they secrete have the potential to be used as natural biocontrol agents to limit the amount of fungal burden at geographic point sources, and therefore limit the potential for human infection.
Efficacy of Biological and Chemical Control Agents against Heterobasidion Spore Infections of Norway Spruce and Scots Pine Stumps on Drained Peatland
Authors: Piri Tuula , Saarinen Markku , Hamberg Leena , Hantula Jarkko , Gaitnieks Talis
Published: March 2023

Treatment of conifer stumps with a control agent effectively prevents Heterobasidion spore infections in summer cuttings and protects the residual stand and the next tree generation from damage caused by Heterobasidion root rot. Thus far, stump treatment experiments have been carried out in mineral soils, and no information is available on the efficacy of stump treatment agents in boreal peatland conditions. In the present study, biological and chemical control agents (Phlebiopsis gigantea and urea, respectively) were tested in Scots pine and Norway spruce stands subjected to thinning, cap cutting, and clearcutting on drained peatland in Central Finland. The control efficacy of urea was high in both spruce and pine stumps (on average 99.5 and 85.3%, respectively), while the efficacy of P. gigantea was highly variable on both tree species and ranged from full protection down to negative control effect, i.e., there were more Heterobasidion infections on the treated than untreated half of the stumps. The moisture content of the stump wood or the thickness of the peat layer did not affect the control efficacy of either control agent. These results emphasize a need for further studies to determine the reasons for the unsteadiness of the biological control in peatland conditions.
Does Impulsive Posting Hurt or Help? The Effects of Conflicting Online Information on Attitude Uncertainty and Behavioural Consequences: The Moderating Role of Peer Social Network Support
Authors: Techinakarawin Tinnanat , Sun Jin
Published: March 2023

Prior research suggests that consumers may find prematurely written online information trivial, nondiagnostic, and most likely to be neglected. This article examines the effects of impulsive posting caused by the incentive algorithm of e-commerce on attitude uncertainty and behavioural consequences. Impulsive posting comprises two perspectives: consumer-generated reviews (i.e., perceived tentativeness and irrelevance of conflicting online reviews) and corporate-generated responses (i.e., perceived depersonalisation of incongruent managerial responses). Our central premise is that facilitating the processing of conflicting information by a systematic route induced by accountability warrants more cognitive resources and amplifies the use of nonoptimal information during attitude formation. Thus, confidence decreases when the information that underlies the attitude is difficult to determine, leading to attitude uncertainty and reverse intentions (i.e., site stickiness and purchase intention).
Inequity in Housing Welfare: Assessing the Inter-City Performance of China’s Housing Provident Fund Program
Authors: Chen Hongyan , Song Jinping , Jiang Huaxiong
Published: March 2023

Accompanied by the monetisation of housing allocation, the Housing Provident Fund (HPF) has become an important part of China’s housing security system. As of 2020, HPF has been implemented for almost 30 years, but limited effort has been made to examine its performance, especially from a spatial (regional) perspective. Taking 287 Chinese cities as a sample and using the “access–process–outcome” framework, this study explores the inter-city differences in the performance of HPF and their relevant influencing factors. The results show that (1) there is significant spatial heterogeneity in the performance of HPF in China; (2) from 2015 to 2020, regional variation in the process and outcome performance showed a convergence trend, but the access performance between cities tended to widen and diverge; (3) regression results show that process-relevant variables (i.e., the contribution rate and the capital utilization level) are positively associated with the loan beneficiary rate (the HPF outcome performance), whereas access-relevant attributes (i.e., the HPF participation rate) exert negative influences. The study contributes to revealing the spatial heterogeneity of China’s HPF development. It highlights that more regionally oriented policy interventions are needed for policy makers and practitioners to optimize the development of HPF.
Characterization and Mapping of Public and Private Green Areas in the Municipality of Forlì (NE Italy) Using High-Resolution Images
Authors: Ottoboni Mara , Pappalardo Salvatore Eugenio , De Marchi Massimo , Ungaro Fabrizio
Published: March 2023

Urban Green Spaces (UGS) contribute to the sustainable development of the urban ecosystem, positively impacting quality of life and providing ecosystem services and social benefits to inhabitants. For urban planning, mapping and quantification of UGS become crucial. So far, the contribution of private green spaces to ecosystem services in urban areas has yet to be studied. At the same time, in many Italian cities, they represent a considerable part of the urban green cover. This study utilises a methodological approach and provides insights into the contribution of urban public and private green spaces by the consideration of a case study area in Northeast Italy. To achieve this goal, the main steps were: (i) NDVI extraction from very high-resolution (20 cm) orthophotos, (ii) classification of property status and (iii) analysis of the degree of the greenness of land cover units. From our results, the total amount of the green spaces is 5.70 km2, of which 72.1% (4.11 km2) is private, and 28.9% (1.59 km2) is public. As for the land cover, three NDVI classes were identified, highlighting different degrees of homogeneity in NDVI reflectance response within each urban land cover unit. These results will support the planning of new green areas in the post-epidemic National Recovery and Resilience Plan.
Mid-Term Follow-Up Study of Children Undergoing Autologous Skin Transplantation for Burns
Authors: Válik Angyalka , Harangozó Katalin , Garami András , Juhász Zsolt , Józsa Gergő , Lőrincz Aba
Published: March 2023

Deep partial and full-thickness burns require surgical treatment with autologous skin grafts after necrectomy, which is the generally accepted way to achieve permanent wound coverage. This study sought to examine the grafted and donor areas of children who underwent autologous skin transplantation, using two assessment scales to determine the severity of the scarring and the cosmetic outcome during long-term follow-up. At the Surgical Unit of the Department of Paediatrics of the University of Pécs, between 1 January 2015 and 31 December 2019, children who had been admitted consecutively and received autologous skin transplantation were analyzed. Twenty patients met the inclusion criteria in this retrospective cohort study. The authors assessed the results using the Patient and Observer Scar Assessment Scale (POSAS) and the Vancouver Scar Scale (VSS). There was a significant difference in how parents and examiners perceived the children’s scars. In the evaluation of the observer scale, the most critical variables for the area of skin grafted were relief and thickness. Besides color, relief was the worst clinical characteristic on the patient scale. However, when medical professionals evaluated the donor site, significantly better results were obtained compared to the transplanted area (average observer scale score: 1.4 and 2.35, p = 0.001; VSS: 0.85 vs. 2.60, p < 0.001), yet it was similar to the graft site in the parents’ opinion (Patient Scale: 2.95 and 4.45, p = 0.181).
Comparative Treatment Study on Macular Edema Secondary to Branch Retinal Vein Occlusion by Intravitreal Ranibizumab with and without Selective Retina Therapy
Authors: Yamamoto Manabu , Miura Yoko , Hirayama Kumiko , Kyo Akika , Kohno Takeya , Theisen-Kunde Dirk , Brinkmann Ralf , Honda Shigeru
Published: March 2023

The purpose of this study was to compare the safety and efficacy of selective retina therapy (SRT) combined with the intravitreal injection of ranibizumab (IVR) in patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO). This trial was a 12-month single-center, randomized, single-masked prospective study. Eligible patients were randomized (1:1) to IVR and SRT (IVR + SRT group), or IVR and sham SRT (IVR + sham group). After the initial IVR, all participants received ME resolution criteria-driven pro re nata treatment. SRT or sham SRT was always applied one day after IVR. The primary outcome measure of this study was the mean change in central macular thickness (CMT) from baseline, and the secondary outcome measures were the mean change in visual acuity from baseline and the number of IVR treatments at a 52-week follow-up. Thirteen patients were in the IVR + SRT group, and 11 were in the IVR + sham group. Compared to the baseline, mean CMT and BCVA improved significantly after 52 weeks in both groups, with no significant difference between the two groups. The mean number of IVR was 2.85 ± 1.52 in the IVR + SRT group and 4.73 ± 2.33 in the IVR + sham group at the 52-week follow-up, with a significant difference between the two groups (p < 0.05). IVR combined with SRT may significantly decrease the number of IVR treatments while maintaining the visual and anatomical improvement effect of IVR monotherapy.
Ion-Induced Lateral Damage in the Focused Ion Beam Patterning of Topological Insulator Bi2Se3 Thin Films
Authors: Gracia-Abad Rubén , Sangiao Soraya , Kumar Chaluvadi Sandeep , Orgiani Pasquale , Teresa José María De
Published: March 2023

Focused Ion Beam patterning has become a widely applied technique in the last few decades in the micro- and nanofabrication of quantum materials, representing an important advantage in terms of resolution and versatility. However, ion irradiation can trigger undesired effects on the target material, most of them related to the damage created by the impinging ions that can severely affect the crystallinity of the sample, compromising the application of Focused Ion Beam to the fabrication of micro- and nanosized systems. We focus here on the case of Bi2Se3, a topological material whose unique properties rely on its crystallinity. In order to study the effects of ion irradiation on the structure of Bi2Se3, we irradiated with Ga+ ions the full width of Hall-bar devices made from thin films of this material, with the purpose of inducing changes in the electrical resistance and characterizing the damage created during the process. The results indicate that a relatively high ion dose is necessary to introduce significant changes in the conduction. This ion dose creates medium-range lateral damage in the structure, manifested through the formation of an amorphous region that can extend laterally up to few hundreds of nanometers beyond the irradiated area. This amorphous material is no longer expected to behave as intrinsic Bi2Se3, indicating a spatial limitation for the devices fabricated through this technique.
Tuning the Red-to-Green-Upconversion Luminescence Intensity Ratio of Na3ScF6: 20% Yb3+, 2% Er3+ Particles by Changes in Size
Authors: Zhang Yongling , Liu Xiang , Song Mingxing , Qin Zhengkun
Published: March 2023

Na3ScF6: 20% Yb3+, 2% Er3+ samples were synthesized with different reaction times and reaction temperatures using the solvothermal method. We carried out a series of tests on Na3ScF6 crystals. The XRD patterns showed that the monoclinic phases of the Na3ScF6 samples could be synthesized under different reaction conditions, and doping with Yb3+ ions and Er3+ ions did not change the crystal structures. The SEM images showed that the sizes of the samples gradually increased with reaction time and reaction temperature. The fluorescence spectra showed that the emission peaks of the prepared samples under 980 nm near-infrared (NIR) excitation were centered at 520 nm/543 nm and 654 nm, corresponding to the 2H11/2/4S3/2→4I15/2 and 4F9/2→4I15/2 transitions, respectively. With the increasing size of the samples, the emission intensities at 654 nm increased and the luminescence colors changed from green to red; at the same time, the red-to-green luminescence intensity ratios (IR/IG ratios) increased from 0.435 to 15.106—by as much as ~34.7 times. Therefore, this paper provides a scheme for tuning the IR/IG ratios of Na3ScF6: 20% Yb3+, 2% Er3+ samples by changing their sizes, making it possible to enhance the intensity of red upconversion, which has great potential for the study of color displays and lighting.
Recent Advances in Electro-Optic Response of Polymer-Stabilized Cholesteric Liquid Crystals
Authors: Lee Kyung Min , Marsh Zachary M. , Crenshaw Ecklin P. , Tohgha Urice N. , Ambulo Cedric P. , Wolf Steven M. , Carothers Kyle J. , Limburg Hannah N. , McConney Michael E. , Godman Nicholas P.
Published: March 2023

Cholesteric liquid crystals (CLC) are molecules that can self-assemble into helicoidal superstructures exhibiting circularly polarized reflection. The facile self-assembly and resulting optical properties makes CLCs a promising technology for an array of industrial applications, including reflective displays, tunable mirror-less lasers, optical storage, tunable color filters, and smart windows. The helicoidal structure of CLC can be stabilized via in situ photopolymerization of liquid crystal monomers in a CLC mixture, resulting in polymer-stabilized CLCs (PSCLCs). PSCLCs exhibit a dynamic optical response that can be induced by external stimuli, including electric fields, heat, and light. In this review, we discuss the electro-optic response and potential mechanism of PSCLCs reported over the past decade. Multiple electro-optic responses in PSCLCs with negative or positive dielectric anisotropy have been identified, including bandwidth broadening, red and blue tuning, and switching the reflection notch when an electric field is applied. The reconfigurable optical response of PSCLCs with positive dielectric anisotropy is also discussed. That is, red tuning (or broadening) by applying a DC field and switching by applying an AC field were both observed for the first time in a PSCLC sample. Finally, we discuss the potential mechanism for the dynamic response in PSCLCs.
Raman Characterization of the In-Plane Stress Tensor of Gallium Nitride
Authors: Han Bowen , Sun Mingyuan , Chang Ying , He Saisai , Zhao Yuqi , Qu Chuanyong , Qiu Wei
Published: March 2023

Experimental characterization of the in-plane stress tensor is a basic requirement for the development of GaN strain engineering. In this work, a theoretical model of stress characterization for GaN using polarized micro-Raman spectroscopy was developed based on elasticity theory and lattice dynamics. Compared with other works, the presented model can give the quantitative relationship between all components of the in-plane stress tensor and the measured Raman shift. The model was verified by a calibration experiment under step-by-step uniaxial compression. By combining the stress characterization model with the expanding cavity model, the in-plane residual stress component field around Berkovich indentation on the (0001) plane GaN was achieved. The experimental results show that the distributions of the stress components, which significantly differed from the distribution of the Raman shift, were closely related to the GaN crystal structure and exhibited a gradient along each crystal direction.
Comparison of the Mechanical Properties and Crack Expansion Mechanism of Different Content and Shapes of Brass-Coated Steel Fiber-Reinforced Ultra-High-Performance Concrete
Authors: Jiang Yanli , Yan Yulong , Li Tianran , Cao Xiuling , Yu Liang , Qi Haiquan
Published: March 2023

Steel fiber-reinforced ultra-high-performance concrete (UHPC) is becoming an important type of concrete reinforcement. After mixing with the reinforced steel fibers, the UHPC has perfect flex resistance, shear strength, crack resistance, shock resistance, and anti-seepage. In this study, the influence of straight, corrugated, and hooked brass-coated steel fibers (BCSFs) on the microstructure, mechanical properties, and crack expansion mechanism of ultra-high-performance concrete (UHPC) with varying content of 1–6 wt.% under different curing times were investigated. Field emission scanning electron microscopy and energy dispersive X-ray spectrometry were employed to characterize the microstructure of the BCSF-reinforced UHPC mix specimens. X-ray computed tomography was employed to determine the porosity of the BCSF-reinforced UHPC mix specimens. The obtained results indicate the flexural strength and compressive strength of BCSF-reinforced UHPC mix specimens are enhanced, along with increasing the content of BCSFs reinforcement with different shapes (straight, corrugated, and hooked). The embedded BCSFs play a major role in the adhesive property and stress transfer of the BCSFs–UHPC matrix interface. Different from many studies, the flexural strength of mix UHPC with straight BCSFs is higher than those with corrugated and hooked BCSFs. However, the compressive strength of UHPC with corrugated BCSFs is higher than those with straight and hooked BCSFs. The flexural strength of mix UHPC with 6 wt.% straight BCSFs at 28 days reaches the maximum value of 26.2 MPa, and the compressive strength of UHPC with 6 wt.% corrugated BCSFs at 28 days reaches the maximum value of 142.3 MPa. With the increase in straight BCSF content from 1 wt.% to 6 wt.%, the porosity in mix UHPC reduces gradually from 18.4% to 8.3%. The length of average crack spacing is dependent on the straight BCSF content. With the increase in straight BCSF content from 1 wt.% to 6 wt.%, the average crack length reduces gradually from 34.2 mm to 12.1 mm, and the average crack width reduces gradually from 0.78 mm to less than 0.1 mm. During crack extension, part of the energy in the UHPC mixture specimen with the 6 wt.% BCSF content flows into the crack tip region converted into the work dissipated during the bridging process. The crack propagation resistance of the UHPC mixture with straight BCSFs was improved compared with those with corrugated and hooked BCSFs. The bond strength between the BCSFs and UHPC matrix was enhanced by using vibrational mixing, and the brass film coated on the BCSFs contributes to increase the flexural and compressive strength of the UHPC mixture.
Identification of Dynamic Behavior Models of Concrete B22.5
Authors: Bragov Anatoly M. , Lomunov Andrey K. , Gonov Mikhail E. , Konstantinov Aleksandr Yu. , Igumnov Leonid A. , Eremeyev Victor A.
Published: March 2023

We discuss experimental and numerical studies of the deformation and destruction of fine-grained concrete B22.5 under dynamic loading. The experiments were carried out using the Kolsky (or split-Hopkinson pressure bar) method, and its modifications in the strain rate range from 400 to 2000 s−1. The rate dependences of ultimate stresses and fracture energy in tension and compression are obtained. Based on experimental data, the identification of the dynamic component of two models from the LS-DYNA computational complex was carried out: *MAT_CONCRETE_DAMAGE and *MAT_CSCM. The results of a comparative analysis of the identified models based on single-element modeling and comparison with experimental data are presented. It is shown that the obtained experimental strain rate dependences of the fracture characteristics can significantly improve the predictive ability of the model compared to the default parameter set. Information about the rate dependence of the fracture energy in *MAT_CSCM model makes it possible to more realistically simulate the behavior of the material beyond the ultimate stress.
Use of Functionally Graded Material to Decrease Maximum Temperature of a Coating–Substrate System
Authors: Yevtushenko Aleksander , Topczewska Katarzyna , Zamojski Przemysław
Published: March 2023

A mathematical model for determining the temperature distribution in the system consisting of a coating deposited on the surface of substrate was proposed. The foundation material is homogeneous, while the coating is made of a functionally gradient material (FGM) with thermal conductivity increasing exponentially along the thickness. Heating processes of the outer surface of the coating were considered with a constant and linearly decreasing in time intensity of the heat flux. Such thermal loads are common in thermal problems of friction, particularly regarding frictional heating during braking. An exact (in quadrature) solution of the corresponding boundary-value problems of parabolic heat conduction was obtained. Asymptotic solutions to these problems were also found for small and large values of the Fourier number. Calculations were performed for a coating made of two-component FGM ZrO2—Ti-6Al-4V, applied on a cast iron substrate. In order to explain the effect of FGM on temperature, corresponding analysis was carried out for the coating made of a homogeneous (ZrO2) material.
Understanding Interfacial Reactions in Ti–Ni Diffusion Couple
Authors: Babaei-Dehkordi Amin , Soltanieh Mansour , Mirjalili Mostafa , Asherloo Mohammadreza , Mostafaei Amir
Published: March 2023

The diffusion phenomenon in the Ti–Ni binary system was investigated at a temperature of 1173 K. Microstructure and texture analysis revealed the formation of three stable intermetallic compounds, namely Ti2Ni, TiNi, and TiNi3, as well as two metastable intermetallic compounds, including Ti3Ni4 and Ti2Ni3, at the interfacial diffusion zone. The nucleation surface energy increase was analytically estimated, and marker experiments were conducted using thoria particles, both of which showed that Ti2Ni was the first compound to form at the Ti–Ni diffusion interface. At a temperature of 1173 K, using the Wagner method, the integrated diffusion coefficients for the Ti2Ni, TiNi, and TiNi3 phases were calculated to be 3.53 × 10−12, 18.1 × 10−15, and 6.2 × 10−15 m2/s, for, respectively.