bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Safety and Efficacy of Axicabtagene Ciloleucel versus Standard of Care in Patients 65 Years of Age or Older with Relapsed/Refractory Large B-Cell Lymphoma
Authors: Westin Jason R. , Locke Frederick L. , Dickinson Michael , Ghobadi Armin , Elsawy Mahmoud , van Meerten Tom , Miklos David B. , Ulrickson Matthew L. , Perales Miguel-Angel , Farooq Umar , Wannesson Luciano , Leslie Lori , Kersten Marie José , Jacobson Caron A. , Pagel John M. , Wulf Gerald , Johnston Patrick , Rapoport Aaron P. , Du Linqiu , Vardhanabhuti Saran , Filosto Simone , Shah Jina , Snider Julia T. , Cheng Paul , To Christina , Oluwole Olalekan O. , Sureda Anna
Published: May 2023

AbstractPurpose:
Older patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) may be considered ineligible for curative-intent therapy including high-dose chemotherapy with autologous stem-cell transplantation (HDT-ASCT). Here, we report outcomes of a preplanned subgroup analysis of patients ≥65 years in ZUMA-7.
Patients and Methods:
Patients with LBCL refractory to or relapsed ≤12 months after first-line chemoimmunotherapy were randomized 1:1 to axicabtagene ciloleucel [axi-cel; autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy] or standard of care (SOC; 2–3 cycles of chemoimmunotherapy followed by HDT-ASCT). The primary endpoint was event-free survival (EFS). Secondary endpoints included safety and patient-reported outcomes (PROs).
Results:
Fifty-one and 58 patients aged ≥65 years were randomized to axi-cel and SOC, respectively. Median EFS was greater with axi-cel versus SOC (21.5 vs. 2.5 months; median follow-up: 24.3 months; HR, 0.276; descriptive P < 0.0001). Objective response rate was higher with axi-cel versus SOC (88% vs. 52%; OR, 8.81; descriptive P < 0.0001; complete response rate: 75% vs. 33%). Grade ≥3 adverse events occurred in 94% of axi-cel and 82% of SOC patients. No grade 5 cytokine release syndrome or neurologic events occurred. In the quality-of-life analysis, the mean change in PRO scores from baseline at days 100 and 150 favored axi-cel for EORTC QLQ-C30 Global Health, Physical Functioning, and EQ-5D-5L visual analog scale (descriptive P < 0.05). CAR T-cell expansion and baseline serum inflammatory profile were comparable in patients ≥65 and <65 years.
Conclusions:
Axi-cel is an effective second-line curative-intent therapy with a manageable safety profile and improved PROs for patients ≥65 years with R/R LBCL.
Data from Reversal of Lactate and PD-1–mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer
Authors: Chaudagar Kiranj , Hieromnimon Hanna M. , Khurana Rimpi , Labadie Brian , Hirz Taghreed , Mei Shenglin , Hasan Raisa , Shafran Jordan , Kelley Anne , Apostolov Eva , Al-Eryani Ghamdan , Harvey Kate , Rameshbabu Srikrishnan , Loyd Mayme , Bynoe Kaela , Drovetsky Catherine , Solanki Ani , Markiewicz Erica , Zamora Marta , Fan Xiaobing , Schürer Stephan , Swarbrick Alex , Sykes David B. , Patnaik Akash
Published: May 2023

AbstractPurpose:
Phosphatase and tensin homolog (PTEN) loss of function occurs in approximately 50% of patients with metastatic castrate-resistant prostate cancer (mCRPC), and is associated with poor prognosis and responsiveness to standard-of-care therapies and immune checkpoint inhibitors. While PTEN loss of function hyperactivates PI3K signaling, combinatorial PI3K/AKT pathway and androgen deprivation therapy (ADT) has demonstrated limited anticancer efficacy in clinical trials. Here, we aimed to elucidate mechanism(s) of resistance to ADT/PI3K-AKT axis blockade, and to develop rational combinatorial strategies to effectively treat this molecular subset of mCRPC.
Experimental Design:
Prostate-specific PTEN/p53-deficient genetically engineered mice (GEM) with established 150–200 mm3 tumors, as assessed by ultrasound, were treated with either ADT (degarelix), PI3K inhibitor (copanlisib), or anti–PD-1 antibody (aPD-1), as single agents or their combinations, and tumors were monitored by MRI and harvested for immune, transcriptomic, and proteomic profiling, or ex vivo co-culture studies. Single-cell RNA sequencing on human mCRPC samples was performed using 10X Genomics platform.
Results:
Coclinical trials in PTEN/p53-deficient GEM revealed that recruitment of PD-1–expressing tumor-associated macrophages (TAM) thwarts ADT/PI3Ki combination–induced tumor control. The addition of aPD-1 to ADT/PI3Ki combination led to TAM-dependent approximately 3-fold increase in anticancer responses. Mechanistically, decreased lactate production from PI3Ki-treated tumor cells suppressed histone lactylation within TAM, resulting in their anticancer phagocytic activation, which was augmented by ADT/aPD-1 treatment and abrogated by feedback activation of Wnt/β-catenin pathway. Single-cell RNA-sequencing analysis in mCRPC patient biopsy samples revealed a direct correlation between high glycolytic activity and TAM phagocytosis suppression.
Conclusions:
Immunometabolic strategies that reverse lactate and PD-1–mediated TAM immunosuppression, in combination with ADT, warrant further investigation in patients with PTEN-deficient mCRPC.
Supplementary Figures S1-S6 and Tables S1-S5 from Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration
Authors: Akagi Keiko , Symer David E. , Mahmoud Medhat , Jiang Bo , Goodwin Sara , Wangsa Darawalee , Li Zhengke , Xiao Weihong , Dunn Joe Dan , Ried Thomas , Coombes Kevin R. , Sedlazeck Fritz J. , Gillison Maura L.
Published: May 2023

Figure S1.1. Circos plots of human genomes.
Figure S1.2. Circos plots of HPV genomes.
Figure S1.3. PacBio HiFi read length distributions.
Figure S1.4. Oxford Nanopore (ONT) read length distributions.
Figure S2.1. Detection of circularized mitochondrial DNA by LR-seq reads.
Figure S2.2. Detection of HPV concatemers by LR-seq reads.
Figure S2.3. ONT reads show structural rearrangements in HPV concatemers.
Figure S3.1. Absence of sequence variants at breakpoints.
Figure S3.2. AmpliconArchitect predicts inaccurate HPV ecDNA structures.
Figure S4.1. Evolution of structural variants at Chr. 22 of Tumor 2.
Figure S4.2. Evidence of heterocateny in Tumor 5 and Tumor 3.
Figure S5.1. HPV integration into icDNA in GUMC-395, HeLa, and HTEC.
Figure S5.2. HPV integrants at Chr. 17 and Chr. X of VU147.
Figure S5.3. Metaphase FISH identifies HPV-containing ecDNAs in cell lines.
Figure S5.4. Circle-seq analysis of HeLa, GUMC-395, VU147, and HTEC cells.
Figure S6. Transcription levels of HPV genes.
Table S1.1. Depths of autosomal and mitochondrial genome sequencing coverage from WGS and LR-seq.
Table S1.2. Depths of autosomal and HPV genome sequencing coverage from WGS and LR-seq.
Table S2.1. Breakpoints and normal segment junctions in Tumor 4.
Table S2.2. Definition of genomic segments flanking HPV integrants in Tumor 4.
Table S3.1. Breakpoints and normal segment junctions in Tumor 2.
Table S3.2. Definition of genomic segments flanking HPV integrants in Tumor 2.
Table S3.3. Breakpoints and normal segment junctions in Tumor 5.
Table S3.4. Definition of genomic segments flanking HPV integrants in Tumor 5.
Table S3.5. Breakpoints and normal segment junctions in Tumor 3.
Table S3.6. Definition of genomic segments flanking HPV integrants in Tumor 3.
Table S4.1. Breakpoints and normal segment junctions in GUMC-395 cells.
Table S4.2. Definition of genomic segments flanking HPV integrants in GUMC-395 cells.
Table S5.1. Breakpoints and normal segment junctions in HeLa cells.
Table S5.2. Definition of genomic segments flanking HPV integrants in HeLa cells.
Table S5.3. Breakpoints and normal segment junctions in VU147 cells.
Table S5.4. Definition of genomic segments flanking HPV integrants in VU147 cells.
Table S5.5. Breakpoints and normal segment junctions in HTEC cells.
Table S5.6. Definition of genomic segments flanking HPV integrants in HTEC cells.
Analisis Keterkaitan Antar Sektor dan Antar Provinsi dalam Perekonomian Kalimantan Tengah Tahun 2016 (Analisis IO dan IRIO)
Authors: Suryani Suryani
Published: May 2023

Regional development does not only rely on the contribution of the economic sector in the region to the economy, but also the interaction of a sector with other sectors as well as inter-regional. The demand for goods and services outside the region has led to efforts to increase production so it encourage economic growth. In other words, economic development in one region is expected to trigger economic development in other regions. The purpose of this study is to determine the leading business sectors, the interrelationships between the business sectors, and the economic linkages of Central Kalimantan with other regions in Indonesia. Using the Input-Output Table (I-O) of Central Kalimantan in 2016, this study succeeded in identifying the leading business sectors in Central Kalimantan and the interrelationships between business sectors in Central Kalimantan. In addition, this study also uses the Inter-Regional Input-Output Table (IRIO) to determine economic linkages between Central Kalimantan and several provinces in Indonesia. The results showed that Iron Ore Mining is a leading sector and one of the leading business sectors in Central Kalimantan. In addition, in terms of regional linkages, it was found that changes in final demand in Central Kalimantan will have a major impact on output in DKI Jakarta, East Kalimantan, and South Kalimantan.
Pengaruh Pengangguran, Kemiskinan, Indeks Pembangunan Manusia, dan Populasi Terhadap Pertumbuhan Ekonomi di Provinsi Kalimantan Tengah
Authors: Prabowo Dhinnessa , Muchtar Masruri , Sihombing Pardomuan Robinson
Published: May 2023

The success or downturn of a country's economy can also be measured by its economic growth rate. This study aims to analyze the influence of unemployment rate, poverty, human development index, and population on economic growth, especially in 14 districts/cities of Central province. Kalimantan for the period 2017-2019. The technique used is a regression analysis of panel data with the best model being the fixed effects model (FEM). The test results show that all variables simultaneously affect economic growth. Partially, unemployment and HDI have negative and insignificant effects on economic growth. Second, poverty has a negative and significant impact while the population has a positive and significant impact on economic growth. Based on the findings of this study, it is recommended from the findings of this study that policies are needed to reduce poverty while increasing population so that economic growth can continue to increase.
Las enfermedades respiratorias y alérgicas: la experiencia del padecimiento desde la perspectiva socio-cultural
Authors:   Universidad de Guadalajara, México, Sevilla Elizabeth , García de Alba García Javier Eduardo ,   Universidad de Guadalajara, México
Published: May 2023

Este ensayo realiza una somera reflexión desde la perspectiva interaccionista, sobre la experiencia del padecimiento de las enfermedades alérgicas en distintos escenarios y su repercusión. Se parte del concepto de bienestar, salud, modo y estilo de vida para adentrarnos a la vivencia y el estigma de los padecimientos respiratorios alérgicos, su imagen corporal, a través de sus manifestaciones clínicas, así como las afectaciones que producen la pobreza, y la educación, detallando ciertos escenarios influyentes de la cotidianidad como el trabajo y las condiciones ambientales de su estilo de vida. Se destaca la necesidad de ofrecer un enfoque sistémico que favorezca un manejo integral y comprensivo, o sea, hacer una reconstrucción articulada de las perspectivas bio-sociales útiles y coherentes para lograr aplicar en la práctica médico-sanitaria el enfoque socio-cultural de salud.
Early Impact of Proton Beam Therapy on Electrophysiological Characteristics in a Porcine Model
Authors: Imamura Kimitake , Deisher Amanda J. , Dickow Jannis , Rettmann Maryam E. , Yasin Omar Z. , Pepin Mark D. , Hohmann Stephan , Konishi Hiroki , Suzuki Atsushi , Newman Laura K. , Sun Xiaojing , Kruse Jon J. , Merrell Kenneth W. , Herman Michael G. , Foote Robert L. , Packer Douglas L.
Published: May 2023

Background:

Particle therapy is a noninvasive, catheter-free modality for cardiac ablation. We previously demonstrated the efficacy for creating ablation lesions in the porcine heart. Despite several earlier studies, the exact mechanism of early biophysical effects of proton and photon beam delivery on the myocardium remain incompletely resolved.

Methods:

Ten normal and 9 infarcted in situ porcine hearts received proton beam irradiation (40 Gy) delivered to the left ventricular myocardium with follow-up for 8 weeks. High-resolution electroanatomical mapping of the left ventricular was performed at baseline and follow-up. Bipolar voltage amplitude, conduction velocity, and connexin-43 were determined within the irradiated and nonirradiated areas.

Results:

The irradiated area in normal hearts showed a significant reduction of bipolar voltage amplitude (10.1±4.9 mV versus 5.7±3.2,
P
<0.0001) and conduction velocity (85±26 versus 55±13 cm/s,
P
=0.03) beginning at 4 weeks after irradiation. In infarcted myocardium after irradiation, bipolar voltage amplitude of the infarct scar (2.0±2.9 versus 0.8±0.7 mV,
P
=0.008) was significantly reduced as well as the conduction velocity in the infarcted heart (43.7±15.7 versus 26.3±11.4 cm/s,
P
=0.02). There were no significant changes in bipolar voltage amplitude and conduction velocity in nonirradiated myocardium. Myocytolysis, capillary hyperplasia, and dilation were seen in the irradiated myocardium 8 weeks after irradiation. Active caspase-3 and reduction of connexin-43 expression began in irradiated myocardium 1 week after irradiation and decreased over 8 weeks.

Conclusions:

Irradiation of the myocardium with proton beams reduce connexin-43 expression, conduction velocity, and bipolar conducted electrogram amplitude in a large porcine model. The changes in biomarkers preceded electrophysiological changes after proton beam therapy.
Effects of Atrioventricular Optimization on Left Ventricular Reverse Remodeling With Cardiac Resynchronization Therapy: Results of the SMART-CRT Trial
Authors: Gold Michael R. , Ellenbogen Kenneth A. , Leclercq Christophe , Lowy Jonathan , Rials Seth J. , Shoda Morio , Tomassoni Gery , Issa Ziad , Sarrazin Jean-Francois , Jennings John M. , Nair Devi G. , Wold Nicholas , Yong Patrick , Harbin Michelle M. , Stein Kenneth M. , Auricchio Angelo
Published: May 2023

Background:

The role of atrioventricular optimization (AVO) to improve cardiac resynchronization therapy outcomes remains controversial. Previous post hoc analyses of a multicenter trial showed that measures of electrical dyssynchrony (right ventricular–left ventricular [LV] or LV electrical delay durations) are associated with patients who benefit from AVO.

Methods:

This was a global, multicenter, prospective, randomized trial of de novo cardiac resynchronization therapy implant patients with an right ventricular–LV duration ≥70 ms to determine whether AVO results in greater reverse remodeling. Patients were randomized 1:1 for either an AVO algorithm (SmartDelay) that determines atrioventricular delay and pacing chamber, biventricular or LV only, or a fixed atrioventricular delay of 120 ms with biventricular pacing. Paired echocardiograms performed at baseline and 6 months were evaluated. The primary end point was echocardiographic cardiac resynchronization therapy response, defined dichotomously as a >15% reduction in LV end-systolic volume.

Results:

A total of 310 patients (n=120 women) were randomized and had completed 6 months of follow-up. The echocardiographic cardiac resynchronization therapy response rate did not statistically differ between the groups (SmartDelay, 74.8%; fixed, 67.7%;
P
=0.17). Analyses of prespecified secondary end points demonstrated significant improvements in the absolute (median: SmartDelay, −41.0 mL; fixed, −33.0 mL;
P
=0.01) and relative change in LV end-systolic volume (SmartDelay, −38.3%; fixed, −27.8%;
P
=0.03) for patients with SmartDelay optimization. Similar results were observed for the relative improvement in LV ejection fraction (SmartDelay, 46.7%; fixed, 32.1%;
P
=0.050); absolute improvement in LV ejection fraction trended to be higher with SmartDelay (
P
=0.06).

Conclusions:

Analysis of reverse remodeling parameters demonstrated that AVO via SmartDelay, relative to the nonoptimized fixed atrioventricular delay comparator group, improved absolute and relative changes in LV function in patients with longer right ventricular–LV duration.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03089281.
Maternal and Fetal Outcomes in Pregnant Patients With Mechanical and Bioprosthetic Heart Valves
Authors: Ng Ayesha P. , Verma Arjun , Sanaiha Yas , Williamson Catherine G. , Afshar Yalda , Benharash Peyman
Published: May 2023

Background

Guidelines for choice of prosthetic heart valve in people of reproductive age are not well established. Although biologic heart valves (BHVs) have risk of deterioration, mechanical heart valves (MHVs) require lifelong anticoagulation. This study aimed to characterize the association of prosthetic valve type with maternal and fetal outcomes in pregnant patients.

Methods and Results

Using the 2008 to 2019 National Inpatient Sample, we identified all adult patients hospitalized for delivery with prior heart valve implantation. Multivariable regressions were used to analyze the primary outcome, major adverse cardiovascular events, and secondary outcomes, including maternal and fetal complications, length of stay, and costs. Among 39 871 862 birth hospitalizations, 4152 had MHVs and 874 had BHVs. Age, comorbidities, and cesarean birth rates were similar between patients with MHVs and BHVs. The presence of a prosthetic valve was associated with over 22‐fold increase in likelihood of major adverse cardiovascular events (MHV: adjusted odds ratio, 22.1 [95% CI, 17.3–28.2]; BHV: adjusted odds ratio, 22.5 [95% CI, 13.9–36.5]) as well as increased duration of stay and hospitalization costs. However, patients with MHVs and BHVs had no significant difference in the odds of any maternal outcome, including major adverse cardiovascular events, hypertensive disease of pregnancy, and ante/postpartum hemorrhage. Similarly, fetal complications were more likely in patients with valve prostheses, including a 4‐fold increase in odds of stillbirth, but remained comparable between MHVs and BHVs.

Conclusions

Patients hospitalized for delivery with prior valve replacement carry substantial risk of adverse maternal and fetal events, regardless of valve type. Our findings reveal comparable outcomes between MHVs and BHVs.
Posterior Covariance Information Criterion for Weighted Inference
Authors: Iba Yukito , Yano Keisuke
Published: May 2023

For predictive evaluation based on quasi-posterior distributions, we develop a new information criterion, the posterior covariance information criterion (PCIC). PCIC generalizes the widely applicable information criterion (WAIC) so as to effectively handle predictive scenarios where likelihoods for the estimation and the evaluation of the model may be different. A typical example of such scenarios is the weighted likelihood inference, including prediction under covariate shift and counterfactual prediction. The proposed criterion uses a posterior covariance form and is computed by using only one Markov chain Monte Carlo run. Through numerical examples, we demonstrate how PCIC can apply in practice. Further, we show that PCIC is asymptotically unbiased to the quasi-Bayesian generalization error under mild conditions in weighted inference with both regular and singular statistical models.
TECHNO-MIND COMPONENTS: ARTIFICIAL CONSCIOUSNESS
Authors: Sergeev Sergey F.
Published: May 2023

Background. Th e problem of artifi cial consciousness is relevant in connection with intensive development of artifi cial intelligence technologies and the complication of technological environment of the mankind, including artifi cial agents and decisionmaking systems. It is widely covered in the interdisciplinary discourse of natural sciences, humanities and engineering. Yet, the unresolved number of fundamental issues of a methodological, systemic, and technological nature constrains its solution. Th e paper considers the problem of creating artifi cial systems that make the world and the technical subject acting in them. Objective. Th e engineering and psychological study had it purpose to investigate the technological possibilities and limitations of creating a system with artificial consciousness based on a permanently operating network learning mechanism. Results. The author proposed a post-non-classical two-stage model of the mechanism of techno-self-organization of artifi cial subjective reality, in which technoconsciousness performs the task of a multi-level multi-qualitative reduction of a part of reality accessible to the cognitive experience of a technical subject. It is substantiated that at the current level of technology development, creating a refl ective consciousness with predetermined properties is impossible. However, engineering methods allow for creating an environment that generates artifi cial subjective reality and refl ective consciousness. Conclusion. The article considers fundamental scientific, methodological, psychological, and technological issues of forming self-organizing processes underlying artifi cial consciousness. Th e author proposed his concept and metaphorical model of the brain as a generative self-organizing environment. Th e study considers the possibility of its implementation in designing and analyzing systems with artifi cial consciousness.
Establishment of the Iranian Specialized Commercial Courts: A Pro-arbitration Stance?
Authors: Ghaffari Sima , Kashkouli Rasoul
Published: May 2023

Following the new approach of the Iranian Judiciary toward the Iranian Commercial Code and recent regulations, including the Guideline pertaining to the establishment of Commercial Courts, specialized commercial branches of Courts were established in Tehran in November 2020. These Commercial Courts are competent to hear, among other types of disputes, arbitration related disputes, both at the domestic and international level.

The role of courts, whether supportive or interventionist, covers matters occurring prior to the commencement of arbitration, during the arbitral proceedings and specifically, after rendering the final arbitral award. It is expected that the specialized commercial judges in these Courts will develop the jurisprudence on arbitration further. Using doctrinal analysis and reviewing some of the latest decisions rendered by these Courts (relating to domestic arbitration), this article explores the jurisdiction of the specialized Commercial Courts and the added value they might bring to the Iranian arbitration forum.

The present article comprises four sections. After recalling the background and jurisdiction of the new Commercial Courts in the first section, the second section will successively explain the potential role of the domestic courts within the arbitration landscape. The third section analyzes the recently published judgements of the Commercial Courts to see how they meet the globally accepted norms and standards in arbitration. The fourth and last section concludes the article which positions the newly established branches of the specialized Commercial Courts as a pro-arbitration stance in Iran. Overall, the article highlights the significance of establishing specialized branches of courts with the presence of judges who are aware of the fundamentals of arbitration in paving the way for Iran to be arbitration friendly.
Erratum: Yang, K.L., Yang, Z.L., Zhang, M., Wang, G.S. & Liu, X. (2023) Gautieria mianjin (Gomphales, Basidiomycota), a new species of false truffle from China. Phytotaxa 594 (2): 119–129.
Authors: YANG KUN L. , YANG ZHU L. , ZHANG MING , WANG GENG-SHEN , LIU XIAO
Published: May 2023

N/A
An annotated catalogue of the Phaegopterina (Erebidae, Arctiinae, Arctiini) of state of Maranhão, Brazil
Authors: SILVA KAROLINE M.O. , CÂMARA JOSELEIDE T. , TESTON JOSÉ A.
Published: May 2023

Phaegopterina moths comprise approximately 750 species recorded in Brazil. In the Cerrado, there are 254 recorded species, while in the Amazon region there are 469. In this study we present an annotated catalogue of species distribution for the Phaegopterina subtribe, recorded in the state of Maranhão for 11 municipalities. After examining the material and reviewing the bibliography, we developed a catalogue containing 119 species within 59 genera of Phaegopterina, of which 26 species are newly recorded for Maranhão, Brazil. The continuous inventory of Arctiinae for Maranhão will contribute to the identification and understanding of the diversity of Lepidoptera present in the region between the Cerrado and Amazon biomes.
Two new species of the genus Stericta Lederer (Lepidoptera, Pyralidae, Epipaschiinae) from Laos and Cambodia
Authors: KIM HANUL , LEE TAK-GI , CHA YEONG-BIN , JANG CHANG-MOON , KIM JEONG-NAM , BAYARSAIKHAN ULZIIJARGAL , BAE YANG-SEOP
Published: May 2023

Two new species, Stericta jaeshini Kim & Bae, sp. nov. and S. atroaurantiaca Kim & Bae, sp. nov. are described from Southeast Asia. About 50 species of the genus Stericta have been recorded from Southeast Asia, but it has not been recorded to occur in Laos and Cambodia previously. We record the presence of this genus in these two countries for the first time in this study. Illustrations of adults and genitalia of examined species are provided. v
The very rare Japanese endemic diving beetle Japanolaccophilus niponensis (Kamiya, 1939), (Coleoptera: Dytiscidae, Laccophilinae): larval morphology and phylogenetic comparison with other known Laccophilini
Authors: ALARIE YVES , WATANABE KOHEI , MICHAT MARIANO C.
Published: May 2023

The three larval instars of Japanolaccophilus niponensis (Kamiya, 1939) (Coleoptera: Adephaga, Laccophilinae) are described for the first time according to the now genevralized larval descriptive format of Dytiscidae (Coleoptera: Adephaga), which incorporates detailed chaetotaxic and morphometric analyses. A parsimony analysis based on larval characteristics of 14 Laccophilini species in seven genera was conducted using the program TNT. One of the main results is that Japanolaccophilus Satô, 1972, which so far was treated as being related to Neptosternus Sharp, 1882 now stands out as sister to Laccophilus Leach, 1815, and Philodytes J. Balfour-Browne, 1938 with strong support. Additionally, Laccomimus Toledo & Michat, 2015, and Africophilus Guignot, 1948 are resolved as monophyletic and sister to a clade which itself is subdivided into two well supported clades: Neptosternus + Australphilus Watts, 1978, and Japanolaccophilus + (Laccophilus, Philodytes). Philodytes is here newly accepted as junior synonym of Laccophilus.
7. A Stroll through the Darkness
Authors: Anonymous
Published: May 2023

In this essay, the anonymous author gives their perspective on the challenges of navigating Western academia as an immigrant while having mental health condition(s). These challenges include continuous self-doubt, isolation, discrimination and the need to reinvent yourself. All this while being subjected to the rather unforgiving culture of continuous assessment in the new workplace and bearing the extra burden posed by mental illness, sometimes without seeking appropriate treatment. These challenges are mutually reinforcing: difficulties of immigrant life can cause or aggravate mental health issues, and health struggles make it more difficult to integrate and succeed in the highly competitive, precarious, and sometimes discriminatory academic environment.
11. Becoming White?
Authors: Andrikopoulos Apostolos
Published: May 2023

In this autobiographical essay, I explore two parallel processes that are somehow interconnected: the first is the shift in my own understanding of race throughout my life, from my formative years in Greece until my recent years in the Netherlands, where I began an academic career as an anthropologist. The second is my own racialization as ‘white’ since I moved to the Netherlands and became an academic. After I outline what were the relevant categories of difference in the small city of Greece where I grew up., I ask how appropriate it is to apply the category of ‘white’ to migrant scholars whose pathway to academia started in contexts in which whiteness had different meanings or was less significant as a marker of privilege.
12. Academic Mobility the ‘Other’ Way
Authors: Kluczewska Karolina
Published: May 2023

The international academic mobility that we hear about most often concerns moving from the non-West to the West. It is far more rare for academics to go the ‘other’ way, i.e. from Western to non-Western academia. While I have been both ways, I owe the really transformative experience of my academic mobility to Tajik academia. This essay describes three of the many aspects of this formative experience, referring to the issues of mistrust, mutual favours and the culture of mediocracy. By being confronted with new academic conventions and practices, Tajik academia made me question my own positionality. It forced me to reflect on privilege and precarity which I simultaneously embodied, and offered a new perspective on Western academic culture.
13. ‘A Small Plot of New Land at All Times’
Authors: Savić Bojan
Published: May 2023

In this chapter, I explore the normalization of my own vulnerability and immigrant otherness through a subjectivity of hope and aspiration. In particular, I embed my problematization of – and coping with – personal precarity (as a working-class Serbian academic in Belgium and the United States) in discourses of aspirational temporality and de-territorialized hope for happiness.
15. Survival in Silence
Authors: Vatansever Asli
Published: May 2023

Looking back on a disturbing past experience, 'Survival in Silence' reflects upon gender inequality, rank hierarchy, precarity, and foreignness in European academia from the perspective of an exiled female researcher. In view of her own conflicting feelings and actions during and after the incident, the author confronts the predicaments of resistance on an individual basis as well as the discrepancies between the theory and practice of feminist solidarity.
17. A Smart Hot Russian Girl from Odessa
Authors: Burlyuk Olga
Published: May 2023

The idea of Ukrainian women as a highly sexualised local product is not only omnipresent in the Internet commercials for ‘hot Russian girls from Odessa’ and ‘best escort girls in Kiev’, but also is regularly fanned at the highest political levels. But what becomes of it when a Ukrainian woman leaves Ukraine to orbit the academic circles? In this essay, I walk down memory lane and recollect my professional interactions at the intersection of gender and ethnicity, spanning 15 years (2006-2020) and offering an elaborate sketch of everyday sexism and gendered racism in academia.
20. Inside the Migrant Academic’s Body
Authors: Sama Khosravi Ooryad Sama Khosravi Ooryad
Published: May 2023

This chapter reflects on my experiences as an early researcher of colour in Dutch academia and in confronting post-graduation challenges. I recount some exclusionary moments that compelled me to realize my own positionality as a ‘strategic outsider’. With the help of previous thinkers who have also felt like outsiders and subsequently theorized ways to navigate ‘outsideness,’ I share examples from my time as a GEMMA student in the Netherlands to illustrate how and why I perceive a need to be constantly alert to exclusionary moments as well as critical of numerous toxicities that any individual in a situation like mine might encounter within and beyond Western academia.
21. ‘Who Deserves a Chair?’
Authors: Rahbari Ladan
Published: May 2023

In this chapter, the author reflects on the performative work that academics do in conference rooms and other spaces of academic performance. The chapter investigates the stark and sometimes harsh differences between research and (self)presentation performances and what happens in more private spaces by using an autobiographic approach. The chapter recounts a narrative based on the author’s experience with microaggressions as a visibly non-white and non-European woman researcher in conference spaces in the Global North. The narrative revolves around multiple experiences of everyday microaggressions and how (a sense of) belonging, and the allocation of time, space, and objects in institutional spaces of performance as its extension is often reserved for those who are considered insiders and ‘kins,’ namely white and mostly Western European academics.
Afterword
Authors: Erel Umut
Published: May 2023

This conclusion chapter reflects on common threads of racism and sexism in migratised academics’ experiences and opportunities for solidarities drawing on elements of life story narratives by the volume’s contributors.
Introduction
Authors: Rahbari Ladan , Burlyuk Olga
Published: May 2023

In the introduction chapter, we draw on the existing literature at the intersection of precarity and migration to show the gap in studies on migrant academics’ precarity and resilience. We outline our aim as decolonization of (former) academics’ narratives of South-North migration. We also provide an outline of the narrative chapters and explain how they speak to each other.
Design an Internet of Things Standard Machine Learning Based Intrusion Detection for Wireless Sensing Networks
Authors: Alalayah Khaled M. , Alaidarous Khadija M. , Alzanin Samah M. , Mahdi Mohammed A. , Hazber Mohamed A. G. , Alwayle Ibrahim M. , Noaman Khaled M. G.
Published: May 2023

At the beginning stage, the wireless module Intrusion Detection System (IDS) is used to address the networking and misuse attacks on computers. Furthermore, the attempt of IDS monitors the network traffic or user activity is malicious. The detection of intrusion contains some challenging
tasks such as detection accuracy, execution time, quality of data, and error. This research designed a novel Bear Smell-based Random Forest (BSbRF) for accurate detection of intrusion by monitoring the behavior and threshold value of each user. Thus the developed electronic-based sensing processor
model was implemented in the python tool and the normal and attack user dataset are collected and trained in the system. Henceforth, pre-processing is employed to remove the errors present in the dataset. Moreover, feature extraction was utilized to extract the relevant features from the dataset.
Then, update bear smell fitness in the random forest classification layer which monitors the behavior and detects the intrusion accurately in the output layer. Furthermore, enhance the performance of intrusion detection accuracy by bear smell fitness. Finally developed model experimental outcomes
shows better performance to detect intrusion and the attained results are validated with prevailing models in terms of accuracy, precision, recall, execution time, and F1 score for wireless sensing mechanism.
Quality of Physical Activity Participation Among Adults with Disabilities Through Pandemic Restriction
Authors: Tao Gordon , Singh Gurkaran , Simpson Ethan , Battalova Alfiya , Rash Isabelle , Mohammadi Somayyeh , Schmidt Julia , Borisoff Jaimie , Mortenson Ben , Miller William C.
Published: May 2023

Background. Physical activity (PA) is essential for maintaining well-being in adults with disabilities. This population experienced reduced PA during the COVID-19 pandemic; yet, the impact on quality of PA participation remains unclear. Purpose. This secondary analysis explored how pandemic restrictions impacted six experiential dimensions of quality of PA participation among adults with disabilities. Methods. An exploratory sequential mixed-methods design, including semi-structured interviews ( n  =  10) and self-reported surveys ( n  =  61), was conducted in May-2020 and February-2021. Quality of PA participation was measured using the Measure of Experiential Aspects of Participation (MeEAP). Participants included community-dwelling adults over 19 years of age (mean 59.2  ±  14.0 years) living with stroke, spinal cord injury, or other physical disabilities. Findings. Directed content analysis identified three themes related to adjusting PA participation for restrictions, motivation barriers, and valuing social support. These themes highlighted five factors, such as resilience, as potential quantitative predictors of quality of PA participation. While paired correlations with MeEAP scores were observed, these factors were not statistically predictive in multiple regression analysis (adjusted R2 = −0.14, F(10,50)  =  0.92, p  =  .53). Implications. The interplay between Meaning, Autonomy, Engagement, and Belongingness dimensions of quality of PA participation was complex, with an emphasized role for mental health, in adults with disabilities.
The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression
Authors: Nettis Maria Antonietta , Lombardo Giulia , Hastings Caitlin , Zajkowska Zuzanna , Mariani Nicole , Nikkheslat Naghmeh , Sforzini Luca , Worrell Courtney , Begum Amina , Brown Mollie , Cleare Anthony J , Young Allan H , Pariante Carmine M , Mondelli Valeria
Published: May 2023

Background and aims:

We investigated kynurenine pathway (KP) metabolites levels and their association with suicidal ideation in patients with treatment-resistant depression (TRD) and elevated peripheral inflammation. The effect of antidepressant augmentation with minocycline on KP metabolites was tested.

Methods:

We analysed data from MINocycline in DEPression, a 4-week, randomized, placebo controlled (1:1) trial of minocycline added to antidepressant treatment in 39 TRD patients ( n = 18 minocycline; n = 21 placebo) with C-reactive protein (CRP) ⩾1 mg/L. At baseline and at week 4, we collected data on suicidality (Beck Depression Inventory) and blood samples to measure inflammatory markers and KP metabolites. We tested (1) the association of KP metabolites ratios with inflammatory markers and suicidal ideation at baseline and (2) the role of suicidality and treatment (minocycline vs placebo) in affecting KP changes over time.

Results:

At baseline, kynurenine/tryptophan (KYN/TRP) ratio positively correlated with high-sensitivity CRP (Spearman’s ρ = 0.35, p = 0.02) and IL-10, (ρ = 0.41, p = 0.009); and tumour necrosis factor was positively correlated with quinolinic acid/3-hydroxykynurenine ratio (ρ = 0.55, p < 0.001). Moreover, participants with suicidal ideation showed higher levels of KYN/TRP ( U = 143.000, p = 0.02) than those without suicidal ideation. There was no significant effect of minocycline on KP metabolites changes from baseline to week 4. However, in the minocycline group, the number of participants with suicidal thoughts decreased from 44.4% (8/18) to 22.2% (4/18).

Conclusion:

Increased KP neurotoxic metabolites are associated with elevated peripheral inflammation in depressed individuals, particularly in those with suicidal ideation. Targeting KP in this population could be a potential effective personalized approach. Whether this includes minocycline should be investigated in future larger trials.
Mentoring: A Traditional Cook Island Approach to Support Men
Authors: Patterson Tess , Egan Richard , Gross Julien , Leov Jessica , Hobbs Linda , La Rooy David
Published: May 2023

The present study examines a unique Cook Island approach to the rehabilitation and support of men, particularly those who have been convicted of criminal offending or who are experiencing other mental health or interpersonal difficulties. The culturally appropriate method of enabling change is offered via a community-based 24-hr mentoring system to support men. Run by men, the program is based on traditional Pacific ways of male mentoring in which one man helps another. This study examines the male mentoring program via qualitative analyses of semi-structured interviews. Seven men who had experienced mentoring and six mentors who deliver the program describe the mentoring system and their experiences. The study identifies several perceived benefits or themes in relation to the program. The unique Cook Islands’ male mentoring program is viewed as beneficial in that it allows males to be open and supported to make change to be re-absorbed into the community, have healthy functioning, and reduce re-offending via the ongoing supportive care.
“ZARPAR”—Educational Program for Cognitive and Behavioral Development: Results of an Experiment to Evaluate Its Impact on Antisocial and Pro-Social Behavior
Authors: Santos Gilda , Santos Margarida , Farrington David P. , da Agra Cândido , Castro Josefina , Cardoso Carla S.
Published: May 2023

Using an experimental design and a multi-measure and multi-informant approach, the current study sought to evaluate the impact of the early developmental prevention program “ZARPAR”—an intervention designed as a social and cognitive skills training program, that seeks to promote children’s behavioral adjustment. A sample of elementary school children (experimental group n = 37; control group n = 66), attending Portuguese schools, was assessed before and 6 months after the intervention on the program’s key-dimensions: behavioral problems, social skills, and executive functioning. Based on parent and teacher reports, the results largely suggested that the intervention had no effect or, for some dimensions, even the existence of negative outcomes. Possible reasons for these results are discussed. The current study highlights that, despite the overwhelmingly positive message about developmental prevention programs, not all interventions work, thus reinforcing the need for rigorous evaluations, in order to enhance the success of future interventions.
Exploring perceived occupational performance among individuals with Vertigo in Jordan: A cross-sectional study
Authors: Ismael Noor T , Nazzal Safa’a K , Jaber Ala’a F , Yabroudi Mohammad A
Published: May 2023

Purpose:

To explore the self-perceived occupational performance in daily life activities in individuals with vertigo in Jordan. Existing evidence is limited on how vertigo affects performing daily life activities like self-care.

Materials and methods:

This study utilized a cross-sectional design, and convenient sampling. Thirty individuals with vertigo ( M = 47.6 years, SD = 15.93) agreed to participate in this study, filled-out the study demographic and condition-related questionnaire, and completed the Canadian Occupational Performance Measure via a semi-structured interview with study research personnel. Data analyses consisted of descriptive statistics, analysis of frequencies, and Analysis of Variance.

Results and conclusions:

Individuals with vertigo reported low to average self-perceived occupational performance ( M = 4.13, SD = 1.64) and satisfaction ( M = 3.46, SD = 1.98). The most challenging area of occupation was self-care (66% of the reported challenging activities), followed by productivity (18%) and leisure (16%). Personal care activities were the most challenging from the self-care area (31%), household management activities from the productivity area (13%), and active recreation activities from the leisure area (7%). In conclusion, individuals with vertigo experience low to average occupational performance and satisfaction in daily life activities. Targeted interventions for individuals with vertigo should increase occupational performance in daily life activities, especially self-care.
Thermal performance of solar air heater having discrete symmetrical arc rib with staggered rib roughness
Authors: Singh Jitendra , Lanjewar Atul
Published: May 2023

This paper investigates physics of forced flow underneath the absorber plate in solar air heater (SAH) integrated with new arc geometry namely discrete symmetrical arc rib with staggered rib roughness. This article signifies the impact of roughness pitch relative to rib height (p/e) on the thermal performance of rectangular roughened SAH duct having discrete symmetrical arc rib with staggered rib (present study). Novel arc rib geometry (present study) is achieved by providing an additional gap in a significantly long continuous arc segment of existing best arc rib geometry to break the boundary layer reformation along it. Range of parameters considered for experimental run for new geometry were Reynolds number (Re) as 3000–15,000, roughness pitch relative to rib height (p/e) of 6–14, flow attack angle (α) of 30°, staggered rib pitch relative to roughness pitch (p′/p) of 0.4, number of symmetrical gap over full arc (Ng) as 6, number of additional gap in symmetrical arc elements (ng) as 5, gap width relative to rib height (g/e) as 3, rib height relative to hydraulic diameter (e/Dh) as 0.043, relative gap position (d/w) and additional gap width relative to rib height (g′/e) as 0.65 and 1 respectively. Five different roughened test plate with the variation of p/e as 6, 8, 10, 12, and 14 were tested. Optimum augmentation is perceived in Nu at p/e as 10 and for f at p/e as 8. Maximum thermo-hydraulic performance parameter (THPP) is achieved at p/e as 10 that corresponds to Re as 6000. Correlation, mathematical model, performance prediction and economic evaluation have also been done under different operation conditions.
Research on high water-based digital valve with dual-spool and control strategy
Authors: He Zhang , Jiyun Zhao , Yunfei Wang
Published: May 2023

The straightness control of the working face is the key technology to realize intelligent production of coal mines. However, the discontinuity of on–off hydraulic components of the existing underground working face cannot meet the needs of intelligent straightness control. A new type of dual-spool high water-based digital valve with a motor ball screw as the driving element is proposed as a solution to this problem. In this paper, the force of the valve is firstly analyzed, and it is found that the force of the movement of the valve core can be equivalent to the disturbance of the motor. The control of the valve core is essentially displacement control. In addition, a mathematical model of the valve is established, and sliding mode control with a high-gain observer is proposed to overcome time-varying characteristics of the load. Theoretical analysis indicates that the proposed controller ensures asymptotic stability with existing uncertain disturbances. Moreover, a system based on MATLAB/Simulink simulation model is developed to further verify the performance of the proposed algorithm. Compared with traditional sliding mode control and proportional integral derivative, the proposed algorithm can still improve the tracking accuracy and robustness along with 0.05 mm error under strong time-varying interference. The valve reaches the required flow in around 0.2 s, which is sufficient for the majority of work surface application situations. The research proposes a novel design concept and control approach for straightening coal mine scraper conveyors.
We Are Still Here: Omission and Perceived Discrimination Galvanized Civic Engagement Among Native Americans
Authors: Dai J. Doris , Yellowtail Jamie L. , Munoz-Salgado Ariana , Lopez Julisa J. , Ward-Griffin Emma , Hawk Crystal Echo , LeBlanc Judith , Santos Nikki , Farero Adam , Eason Arianne E. , Fryberg Stephanie A.
Published: May 2023

Leading up to the 2020 U.S. presidential election, Native American organizations and tribes launched get-out-the-vote campaigns that motivated Native peoples to vote in record numbers and helped flip battleground states. We conducted four studies (total N = 11,661 Native American adults) to examine the social and cultural factors explaining this historic Native civic engagement (e.g., campaigning). Results revealed that the more participants identified as being Native, the more they reported (a) engaging in civic activities, including get-out-the-vote behaviors during the 2020 election (Study 1); (b) civic engagement more broadly across a 5-year period (pilot study, Study 2); and (c) intentions to engage in civic activities in the future (Study 3). Moreover, participants who more strongly identified as Native were more likely to recognize the omission of their group from society and perceive greater group discrimination, which both independently and serially predicted greater civic engagement. These results suggest that leveraging the link between Native identification and group injustices can motivate action.