bluuebunny/crossref_metadata_2025 huggingface dataset:
Glosa do wyroku Wojewódzkiego Sądu Administracyjnego w Gdańsku z dnia 3 listopada 2020 r., sygn. I SA/Gd 316/20
Authors: Stachurski Tomasz
Published: November 2021

Celem glosy jest podjęcie dyskusji z istotnym poglądem sądów administracyjnych dotyczącym rozumienia przesłanki udzielenia ulgi w spłacie zobowiązań podatkowych, jaką jest interes publiczny. Zgodnie ze stanowiskiem sądu wadliwe obliczenie przez podatnika podatku, spowodowane niejasnością obowiązującego i zmieniającego się prawa podatkowego, może przemawiać za ziszczeniem się tejże przesłanki. Wykorzystując metodę analizy dogmatycznej przepisów prawnych oraz badając orzecznictwo sądów administracyjnych i poglądy doktryny, wskazano zarówno argumenty przemawiające za przyjętym rozumieniem klauzuli generalnej interesu publicznego, jak i pewne niebezpieczeństwa z nim związane. Kwestia ta jest istotna, ponieważ nieokreśloność przesłanki interesu publicznego powinna skłaniać do jej dynamicznego, zmieniającego pojmowania, a zatem także do prowadzenia dyskusji na ten temat w doktrynie i orzecznictwie. W glosie rozważono również zagadnienie możliwości powoływania się przez państwo na upływ wynikającego z przepisów wewnętrznych terminu wygaśnięcia prawa do zwrotu nadpłaty podatku, w sytuacji gdy zgodnie z umową o unikaniu podwójnego opodatkowania podatek był nienależny. W tej sprawie udzielono odpowiedzi negatywnej, gdyż takie działanie wydaje się niezgodne z zasadami prawa międzynarodowego.
“Liguei o rádio pra conferir se era verdade”: a credibilidade do radiojornalismo local em tempos de fake news
Authors: Medeiros Rafael , Prata Nair
Published: November 2021

As emissoras locais de rádio têm suas programações jornalísticas ancoradas em informações relevantes para o cotidiano da comunidade, contribuindo para a proximidade simbólica com o ouvinte. A credibilidade de um meio de comunicação depende de convenções pré-estabelecidas com sua audiência em contratos de leitura consensuais. Dessa forma, a proposta do artigo é evidenciar os lugares de credibilidade do radiojornalismo local em tempos de diminuição da confiança na imprensa e da difusão de fake news. A pesquisa de recepção, que originou este recorte, tem base multimetodológica e combina aplicação de questionários e realização de entrevistas de história oral e semiestruturadas para analisar os discursos de ouvintes da Rádio Itatiaia Ouro Preto sobre suas experiências de escuta, relação com a cidade de Ouro Preto (MG) e percepções sobre o processo de migração da rádio para FM. Utilizando Análise Textual Discursiva, as entrevistas são exploradas aqui à luz da noção de credibilidade do rádio local. Os resultados apontam que o radiojornalismo local segue como a principal e mais confiável fonte de informação para populações de pequenas cidades.
PENGARUH SOCIAL CAPITAL DAN HUMAN CAPITAL TERHADAP BUSINESS GROWTH PENGUSAHA PEREMPUAN DI JAKARTA DAN TANGERANG [EFFECT OF SOCIAL CAPITAL AND HUMAN CAPITAL ON BUSINESS GROWTH OF WOMEN ENTREPRENEURS IN JAKARTA AND TANGERANG]
Authors: Hutabarat Zoel , Dini Shania Jusan
Published: November 2021

The aim of this study is to examine the positive effect of social capital, human capital, reputational capital on business growth on women entrepreneurs in Jakarta dan Tangerang. Intangible assets are widely regarded as a key success factor for business growth in various countries. The growth of women's businesses in developing countries is still rare to find, but in recent years women have been seen to be more active in terms of entrepreneurship and business with women's ownership continues to grow to this day. This study uses a quantitative approach. The data collection technique in this study used an electronic questionnaire via Google Form, consisting of 31 indicators and the number of respondents was 201 respondents who are women and currently have businesses. The analytical method used in this research is SmartPLS 3.0, and in distributing the questionnaire, this study uses judgment sampling technique. The results of this study conclude that social capital has a positive effect on business growth, human capital has a positive effect on business growth, individual reputation capital has a negative effect on business growth, and organization reputational capital has a positive effect on business growth.
KONTRIBUSI PEMIMPIN TERHADAP KEPUASAN KERJA KARYAWAN [LEADER'S CONTRIBUTION TO EMPLOYEE'S JOB SATISFACTION]
Authors: Noferian Aldy , Hutabarat Zoel
Published: November 2021

This study aims to determine the effect of the leader-subordinate relationship, task structure, and strength of the leader's position on job satisfaction of Bank X employees in Jakarta and South Tangerang. This research is a quantitative research with survey using online questionnaire with Likert scale with 105 respondents who are employees of Bank X in Jakarta and South Tangerang. The results of this study indicate that the leadership-subordinate relationship, task structure, and strength of the leader's position altogether affect job satisfaction of Bank X’s employees in Jakarta and South Tangerang. Partially, the task structure and strength of the leader's position variables affect job satisfaction, while the leader-subordinate relationship has no effect on job satisfaction. This study emphasizes the relationship between the leader and subordinates, task structure and strength of the leader's position in order to be maintained so that employee productivity can increase in the company.

BAHASA INDONESIA ABSTRACT:

Penelitian ini bertujuan untuk mengetahui pengaruh hubungan pimpinan-bawahan, struktur tugas, dan kekuatan posisi pemimpin dengan kepuasan kerja karyawan Bank X di Jakarta dan Tangerang Selatan. Penelitian ini merupakan penelitian kuantitatif dengan survei menggunakan kuesioner online dengan skala Likert kepada 105 responden yang merupakan karyawan Bank X di Jakarta dan Tangerang Selatan. Hasil penelitian ini menunjukkan bahwa hubungan pimpinan-bawahan, struktur tugas, dan kekuatan posisi pemimpin secara bersama-sama berpengaruh terhadap kepuasan kerja karyawan Bank X di Jakarta dan Tangerang Selatan. Secara parsial, variabel struktur tugas dan kekuatan posisi pemimpin berpengaruh kepada kepuasan kerja sedangkan hubungan pimpinan-bawahan tidak berpengaruh terhadap kepuasan kerja. Penelitian ini menekankan hubungan antara pimpinan dengan bawahan, struktur tugas dan kekuatan posisi pemimpin agar tetap terjaga sehingga produktivitas karyawan dapat meningkat dalam perusahaan.
FORMULATION TECHNIQUES OF ORGANIZATIONAL STRATEGIES IN JAKARTA (CASE STUDY: INSURANCE COMPANIES IN JAKARTA)
Authors: Suryawan Ian Nurpatria , Yulisnada Yulisnada , Mardony Denyus , Lukito Jefri
Published: November 2021

Strategy becomes important for every organization to win competition through changes in internal and external environmental factors. Strategy requires strength, effort and good analysis to anticipate each challenge. Pearce and Robinson explain the stages of strategy management that produce strategy formulation techniques so that the strategies made by the organization are directed and correct. The method used in this research is discussion of qualitative descriptive research through proof of research that has been carried out by previous researchers regarding strategy. The results is business competitions in insurance products nowadays need to be responded by providing the best possible service therefore the insurance products are increasingly demanded by customers in this globalization era which is marked by rapid positive and negative impact on the organization. Thus, it is necessary to be careful in managing every organizational resources, not only focusing on internal organizational factors, but also external factors by utilizing any opportunities or threats that affect the organization both directly and indirectly. The CEOs of insurance company require to make analysis and formulation techniques to apply strategies in the form of winning competition and creating competitive advantage.
THE IMPLEMENTATION OF CARE COORDINATION MODEL TOWARD DELIVERY OF QUALITY CARE IN PRIVATE HOSPITAL OUTPATIENT SETTING
Authors: Ricca Rica , Antonio Ferdi
Published: November 2021

Health care services in the private hospitals are required to deliver quality care to stay competitive in the business. In line with the advancement of hospital facilities and the raise of patient needs for complex care, the care coordination is inevitable to ensure the delivery quality of care. The purpose of this study is to test and analyze the care coordination model toward delivery of quality care in the private hospital outpatient setting. This research model was empirically tested on outpatient clinic at one of the leading hospitals in Indonesia. The data was analyzed by PLS-SEM method, whereas respondent obtained by purposive sampling technique. The result of structural model, shown moderate to strong prediction accuracy with large predictive relevance indicate and acceptable model. The result demonstrated that all of care coordination paths lead to the delivery of quality care has significant positive effect, except for facilitate transitions and accountability to communication and information transfer. However, facilitate transitions and accountability has significant positive effect through IT-enabled care coordination and through interprofessional teamwork and consistency. Therefore, it could be concluded that all variables have contribution to the care coordination in the outpatient, respectively. The strongest direct effect to care quality perception is found from communication and information transfer, while the strongest indirect effect is from physical infrastructure and facilities which mediating by IT-enabled care coordination and further communication and information transfer. There are managerial implications that could give suggestions for hospital managers to improve care coordination process in hospital outpatient services.
HOSPITAL'S REDOWSKO APPLICATION FORMS AND INFLUENCE IN ACTION
Authors: Eni Yuli , Layman Chrisanty
Published: November 2021

The rise of the current digital era brought by further sophisticated technology increases access to global information and advancement in various industry application. In 2012, Hospital Accreditation Commission KARS launched an application to assist hospitals in accreditation assessment. Due to the lack of understanding and perception of accreditation standards, improvements were made to develop new standards using a methodology called ReDOWSKo. This study will look into measuring the use between ReDOWSKo application and book form. Data was collected using google form questionnaire and analyzed using descriptive statistic and correlation method. The results show there is a relationship between the ReDOWSKo assessment in the form book and application with the nature of weak and unidirectional relationships. In this case the application is used to help remember important elements in accreditation. There is also correlation that is statistically significant between application users and book users and there is a positive relationship between the use of ReDOWSKo book form with application form. This application relatively new, and have little literature found while the use of the ReDOWSKo application is indeed considered not yet optimal. This study suggest it would require time for adoption of the use of the application that could enhance the effectiveness of ReDOWSKo. Therefore, will include upgrading the application and further socialization and training in the upcoming years.
ISLAND AND ANABRANCHING GENERATION PROCESSES – A COMPARATIVE REVIEW IN THE UPPER PARANÁ RIVER
Authors: Leli Isabel Terezinha , Hayakawa Ericson Hideki , Santos Vanessa Cristina dos , Stevaux José Cândido
Published: November 2021

Although the anabranching channel pattern is frequent in rivers of different sizes and climates, understanding the processes involved in its genesis requires further research, especially focusing on island formation. This article discusses the processes involved in anabranching patterns and island formation, focusing on the environmental characteristics and sedimentary records in a stretch of the Upper Paraná River - PR. We compare the results with concepts and definitions in the literature. Islands in the Upper Paraná River form in two ways: from 1) the stabilization of central bars (in-channel processes) and 2) the floodplain cutoff (off-channel processes). The islands of the first case are generally smaller and younger than those formed by off-channel processes. Both islands can expand their surface by attaching lateral bars. Multi-channeling, island formation, and permanence can be explained through the concept of maximum flow efficiency.
Causality Analysis of South Africa Reserve Bank’s Monetary Policy Statements and Communication
Authors: Segawa Arnold
Published: November 2021

This paper inspects whether the South Africa Reserve Bank’s (SARB) Monetary Policy Committee (MPC) statements trigger have a causality with newspaper reports from the Mail and Guardian between 2010 and 2021. The study examines whether SARB’s post MPC statements’ readability is reciprocated in the subsequent Mail and Guardian newspaper articles. Using the Flesch Reading Ease Score and Flesch-Kincaid Grade Level score as the methodology, there is a systematic unpacking of both SARB’s MPC statements and newspaper reports from the Mail and Guardian which yield a dataset which is subsequently used to create a computation. This computation is then used to examine whether SARB’s MPC statements Granger cause the subsequent Mail and Guardian newspaper articles. Resultantly, the results show that there is no Granger causality between the SARB’s MPC statements and the Mail and Guardian’s Flesch Reading Ease Score and Flesch-Kincaid Grade Level score.
DIGITAL LITERACY IN THE TRANSFORMATION OF HISTORICAL LEARNING IN THE TIME OF COVID-19
Authors: Mardiani Fitri , Anis Mohamad Zaenal Arifin , Hermawan Muhammad Dody
Published: November 2021

Abstract Change layout: how to learn and learn the history that occurred due to the Covid-19 pandemic that hit almost all over the world, especially in the field of education and learning history in the department of history of education FKIP ULM. In addition to the challenges of the times, global change is increasingly urgent because of a transformation in the education system and learning in Indonesia. In accordance with the demands that we should be able to survive in the midst of the complexity of the challenge and complexity of life in the pandemic. Digital technologies continue to evolve into an integral part in the education world additionally traffic digital literacy to be an ability that must be possessed to be able to explore the information, the message and also process them with good so right on target. This research uses descriptive qualitative research methods, analyzing the extent to which the understanding related to digital literacy in the transformation of learning the history of the covid-19 in the online learning of History of Education Department of FKIP ULM
LOCAL WISDOM IN BANJAR CULTURAL PERSPECTIVE
Authors: Wahyu Wahyu
Published: November 2021

Kearifan lokal adalah milik masyarakat lokal. Kearifan lokal ini dihayati, dipraktikan, diajarkan dan diwariskan dari satu generasi ke generasi lain yang sekaligus membentuk pola perilaku manusia sehari-hari, baik terhadap sesama manusia maupun terhadap alam. Kearifan lokal adalah nilai-nilai luhur yang diyakini kebenarannya, berlaku di dalam tatanan kehidupan masyarakat lokal dan bertujuan untuk melindungi sekaligus mengelola lingkungan hidup secara lestari. Kalimantan Selatan merupakan salah satu Kota yang memiliki kearifan lokal yang beragam, baik kearifan lokal yang telah lama ada diwariskan dari generasi ke generasi maupun kearifan lokal yang baru muncul sebagai hasil interaksi dengan masyarakat dan budaya lain. Paradigma ilmu pengetahuan dan teknologi modern sekarang ini telah mempengaruhi hilangnya sebagian nilai-nilai kearifan lokal. Karena itu, upaya menggali, menemukan, membangun dan melestarikan nilai-nilai kearifan lokal menjadi suatu kebutuhan.
Akademik Erteleme Davranışını Azaltmaya Yönelik Gerçeklik Terapisine Dayalı Grup Rehberliği Programının Etkisi
Authors: ASLAN Suzan , TUNÇ Erhan
Published: November 2021

Bu araştırmanın temel amacı, ortaöğretim öğrencilerinde gerçeklik terapisine dayalı akademik erteleme davranışını azaltmaya yönelik grup rehberliği programının akademik erteleme davranışına etkisini incelemektir. Araştırmada deney ve kontrol grubu olarak belirlenen katılımcılar 2020-2021 eğitim öğretim yılında Gaziantep İli Şahinbey İlçesinde yer alan Anadolu Lisesinde öğrenim gören 218 öğrenci arasından seçilmiştir. Çalışmaya gönüllü olarak katılan öğrencilerden sözlü onayla birlikte yazılı onay da alınmıştır. Ardından akademik erteleme ölçeğine verdikleri cevaplardan elde edilen puan ortalamalarının bir standart sapma üzerinde puan alan öğrenciler arasından kura yöntemi ile bir grup deney bir grup kontrol grubu olacak şekilde iki gruba atanmıştır. 8 hafta süren grup rehberliği programının sona ermesinden 8 hafta sonra kalıcılığı belirlemek amacıyla izleme testi yapılmıştır. Bu çalışmada Akademik Erteleme Ölçeği Cronbach Alpha güvenirlik katsayısı ise .86 olarak bulunmuştur. Bu araştırmanın sonuçlarına göre, Gerçeklik Terapisine dayalı olarak geliştirilen psikoeğitim programının deney grubunda yer alan öğrencilerin akademik erteleme davranışlarını azaltma yönünde etkisi olduğu görülmüştür. Grup rehberliği programına katılan deney grubu katılımcılarının akademik erteleme son test puan ortalamaları, ön test puan ortalamalarından anlamlı olarak düşüktür.
Statistical Modelling of Machining Error for Model-Based Elastomer End-Milling
Authors: Chainawakul Adirake ,   Division of Engineering, Muroran Institute of Technology 27-1 Mizumoto-cho, Muroran, Hokkaido 050-8585, Japan, Teramoto Koji , Matsumoto Hiroki
Published: November 2021

Elastomer end-milling has attracted attention for use in the small-lot production of elastomeric fragments because the technique is an applicable method for a large variety of materials and does not require the preparation of expensive and time-consuming moulds. In order to effectively utilize elastomer end-milling, it is necessary to ensure the machining accuracy of elastomeric parts machined through this technique. However, the control method of machining error in the elastomer end-milling has not been presented since most machining services of the elastomeric part are based on enterprise-dependent dexterities or know-how. The objective of this paper is to construct and utilize a machining error model for elastomer end-milling. A statistical model based upon physical states and machining conditions is introduced and investigated. In this paper, a framework for modelling the machining error in elastomer end-milling is also proposed. In the framework, the candidates of model variables are evaluated based on the preliminary experiments. Moreover, a statistical model is constructed by using the selected variables. Candidate variables are cutting conditions and predictable physical state variables such as workpiece deformation and cutting force. The framework is investigated by evaluating error prediction with the experimental results. An identified error model from limited machining cases can estimate the machining error of different machining cases. The results indicate that the proposed modelling method is capable of supporting to achieve model-based precision elastomer end-milling.
Total Joint Arthroplasty in HIV-Positive Patients in Malawi
Authors: Graham Simon Matthew , Render Luke , Moffat Chipiliro , Lubega Nicholas , Mkandawire Nyengo , Young Sven , Harrison William J.
Published: November 2021

Background:

In this observational study, we describe the medium-term outcomes of total joint arthroplasty (TJA) in human immunodeficiency virus (HIV)-positive patients in Malawi, a low-income country. With a high prevalence of HIV and increasing arthroplasty rates in low and middle-income countries, understanding the outcomes of TJA in this unique cohort of patients is essential to ensure that surgical practice is evidence-based.

Methods:

Data for all HIV-positive patients who had TJA from January 2005 to March 2020 were extracted from the National Arthroplasty Registry of the Malawi Orthopaedic Association (NARMOA). From January 2005 to March 2020, a total of 102 total hip arthroplasties (THAs) and 20 total knee arthroplasties (TKAs) were performed in 97 patients who were HIV-positive and without hemophilia or a history of intravenous drug use. The mean length of follow-up was 4 years and 3 months (range, 6 weeks to 15 years) in the THA group and 4 years and 9 months (range, 6 weeks to 12 years) in the TKA group. The mean patient age was 50 years (range, 21 to 76 years) and 64 years (range, 48 to 76 years) at the time of THA and TKA, respectively.

Results:

The primary indication for THA was osteonecrosis (66 hips). In the THA group, the mean preoperative Oxford Hip Score and Harris hip score were 14.0 (range, 2 to 33) and 29.4 (range, 1 to 64), respectively, and improved to 46.6 (range, 23 to 48) and 85.0 (range, 28 to 91) postoperatively. The primary indication for TKA was osteoarthritis (19 knees). The mean preoperative Oxford Knee Score was 14.9 (range, 6 to 31) and increased to 46.8 (range, 40 to 48) postoperatively. In patients who underwent THA, there was 1 deep infection (1 of 102 procedures), and 6 patients developed aseptic loosening (6 of 102). There was 1 postoperative superficial infection following TKA (1 of 20 procedures), and 1 patient developed aseptic loosening (1 of 20). Postoperative 6-week mortality among all patients was zero.

Conclusions:

To our knowledge this is the largest medium-term follow-up of HIV-positive patients, without hemophilia or a history of intravenous drug use, who have had TJA in a low-income country. This study demonstrated good medium-term results among HIV-positive patients undergoing TJA, low complication rates, and improvements in patient-reported outcome measures.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Fine Mapping of Powdery Mildew Resistance Gene MlWE74 Derived From Wild Emmer Wheat (Triticum Turgidum ssp. Dicoccoides) in An NBS-LRR Gene Cluster
Authors: Zhu Keyu , Li Miaomiao , Wu Haibin , Zhang Deyun , Dong Lingli , Wu Qiuhong , Chen Yongxing , Xie Jingzhong , Lu Ping , Guo Guanghao , Zhang Huaizhi , Zhang Panpan , Li Beibei , Li Wenling , Dong Lei , Wang Qifei , Zhu Jinghuan , Hu Wenli , Guo Liqiao , Wang Rongge , Yuan Chengguo , Li Hongjie , Liu Zhiyong , Hua Wei
Published: November 2021

Wheat powdery mildew, caused by Blumeria graminis f. sp. tritici ( Bgt ), is a globally devastating disease. Wild emmer wheat ( Triticum turgidum var. dicoccoides ) is a valuable genetic resource for improving disease resistance in common wheat. A powdery mildew resistance gene was transferred to hexaploid wheat line WE74 from wild emmer accession G-748-M. Genetic analysis revealed that the powdery mildew resistance in WE74 is controlled by a single dominant gene, herein temporarily designated MlWE74 . Bulked segregant analysis (BSA) and molecular mapping delimited MlWE74 to the terminal region of chromosome 2BS flanking by markers WGGBD412 and WGGBH346 within a genetic interval of 0.25 cM and corresponding to 799.9 kb genomic region in the Zavitan reference sequence. Sequence annotation revealed two phosphoglycerate mutase-like genes, an alpha/beta-hydrolases gene, and five NBS-LRR disease resistance genes that could serve as candidates for map-based cloning of MlWE74 . The geographical location analysis indicated that MlWE74 is mainly distributed in Rosh Pinna and Amirim regions, in the northern part of Israel, where environmental conditions are favorable to the occurrence of powdery mildew. Moreover, the co-segregated marker WGGBD425 is helpful in marker-assisted transfer of MlWE74 into elite cultivars.
Prussian Blue Analogues Derived CuO@Co3O4 Nanoparticles As Effective Oxygen Reduction Reaction Catalyst For Magnesium-Air Battery
Authors: Dong Xiaoyang , Wang Jinxing , Wang Xiao , Yang Jingdong , Zhu Ling , Zeng Wen , Wang Jingfeng , Pan Fusheng
Published: November 2021

Developing efficient, durable and cost-effective non-noble metal catalysts for oxygen reduction reaction (ORR) is remarkably significant to promote the efficiency and performance of Mg-air battery. Herein, the CuO@Co3O4 nanoparticles are synthesized by a low-cost and simple approach using the CuCo-based prussian blue analogues (PBA) as precursor of pyrolysis at different calcination temperatures. It is found that the CuO@Co3O4 nanoparticles calcined at 600 ºC (CCO-600) have relatively small size and superior ORR performance. The onset potential is 0.889 V and the diffusion limiting current density achieves 6.746 mA·cm-2, as well as prominent stability in 0.1 M KOH electrolyte. The electron transfer number of the CCO-600 is 3.89 under alkaline medium, which manifests that the reaction mechanism of ORR is dominated by 4 e process. It is similar to the commercial Pt. Moreover, the primary Mg-air battery with the CCO-600 as the cathode catalyst has been assembled. The Mg-air battery of the CCO-600 as the cathode catalyst possesses better discharge performance than the CuCo-based PBA. The open circuit voltage of CCO-600 arrives 1.76 V and energy density of 1895.95 mWh/g. This work provides an effective strategy to develop non-noble metal ORR catalyst for the application of metal-air batteries.
The Autonomous Sensory Meridian Response Activates the Parasympathetic Nervous System
Authors: Tada Kanae , Ezaki Takahiro , Kondo Hirohito M.
Published: November 2021

The autonomous sensory meridian response (ASMR) produces a tingling sensation with positive feelings when binaural sounds are presented through headphones. This crossmodal response is believed to be related to sensory integration, but its psychological and physiological mechanisms are largely unknown. We conducted two experiments (on thirty and forty-two participants, respectively) to measure the subjective intensity of ASMR, finger photoplethysmography (PPG), and shift in mental states during their ASMR experience. We found that the intensity of ASMR was greater when auditory and visual stimuli were presented simultaneously than when only auditory stimuli were presented. This suggests the involvement of sensory-based, bottom-up processing. Furthermore, their pulse rates decreased and PPG amplitudes increased during the ASMR experience. Self-reported measures showed that the ASMR experience shifted participant’s negative moods to neutral mental states. These results suggest that the parasympathetic nervous system is dominant during the ASMR experience.
Mitochondrial COX4-1 deficiency leads to impaired nuclear DNA damage response resulting in proliferation deficits and premature senescence
Authors: Douiev Liza , Miller Chaya , Benyamini Hadar , Abu-Libdeh Bassam , Saada Ann
Published: November 2021

Cytochrome- c- oxidase (COX), a multimeric protein complex, is the final electron acceptor in the mitochondrial electron transfer chain. Primary COX deficiency, caused by mutations in either mitochondrial DNA or nuclear-encoded genes, is a heterogenous group of mitochondrial diseases with a wide range of presentations ranging from fatal infantile to subtler. We previously reported a patient with primary COX deficiency due to a pathogenic variant in COX4I1 (encoding the common isoform of COX subunit 4), who presented with bone-marrow failure, genomic instability and short stature, mimicking Fanconi anemia (FA). In the present study, we demonstrated reduced proliferation and premature senescence in this patient’s fibroblasts and in COX4-1 knockdown cells. Accumulative DNA damage coincided primarily with proliferative cells, indicating replicative stress. Expression analysis implicated DNA damage response which was verified by demonstrating impaired recovery from genotoxic insult and decreased DNA repair. Interestingly, our in-vitro findings recapitulate the patient’s presentation and present status. Thus, we suggest that the premature senescence, resulting from accumulative DNA damage in COX4-1 deficiency is a protective mechanism to avoid malignant transformation in a similar manner to what was reported for FA and other “accelerated aging diseases”.
Antiskyrmions and their electrical footprint in crystalline mesoscale structures
Authors: Winter Moritz , Goncalves Francisco J. T. , Soldatov Ivan , He Yangkun , Céspedes Belén Zéuniga , Milde Peter , Lenz Kilian , Hamann Sandra , Uhlarz Marc , Vir Praveen , König Markus , Moll Philip J. W. , Schlitz Richard , Goennenwein Sebastian T. B. , Eng Lukas M. , Schaefer Rudolf , Wosnitza Joachim , Felser Claudia , Gayles Jacob , Helm Toni
Published: November 2021

Skyrmionics materials hold the potential for future information technologies, such as racetrack memories. Key to that advancement are skyrmionics systems that exhibit high tunability and scalability, with stored information being easy to read and write by means of all-electrical techniques. Topological magnetic excitations, such as skyrmions and antiskyrmions give rise to a characteristic topological Hall effect (THE) in electrical transport. However, an unambiguous transport signature of antiskyrmions, in both thin films and bulk samples has been challenging to date. Here we apply magnetosensitive microscopy combined with electrical transport to directly detect the emergence of antiskyrmions in crystalline microstructures of Mn1.4PtSn at room temperature. We reveal the THE of antiskyrmions and demonstrate its tunability by means of finite sizes, field orientation, and temperature. Our atomistic simulations and experimental anisotropy studies demonstrate the link between antiskyrmions and a complex magnetism that consists of competing ferro- and antiferromagnetic as well as chiral exchange interactions.
Evaluation of the feasibility of the FAST-M maternal sepsis intervention in Pakistan, a protocol
Authors: Ahmed Sheikh Irfan , Sikandar Raheel , Barolia Rubina , Khowaja Bakhtawar M.Hanif , Memon Kashif Ali , Cheshire James , Dunlop Catherine , Coomarasamy Arri , Sheikh Lumaan , Lissauer David
Published: November 2021

Background

Maternal sepsis is a life-threatening condition, defined by organ dysfunction caused by infection during pregnancy, childbirth and the postpartum period. It is estimated to account for between one tenth and half of all maternal deaths globally. An international stake-holder group, including the World Health Organization, developed a maternal sepsis management bundle called “FAST-M” for resource limited settings through a synthesis of evidence and international consensus. The FAST-M treatment bundle consists of five components: Fluids, Antibiotics, Source identification and control, assessment of the need to Transport or Transfer to a higher level of care and ongoing Monitoring (of the mother and neonate). This study aims to adapt the FAST-M intervention and evaluate its feasibility in Pakistan.
Methods

The proposed study is a mixed method, with a before and after design. The study will be conducted in two phases at Liaquat University of Medical and Health Sciences, Hyderabad. In the first phase, we will adapt the bundle care tools for the local context and assess in what circumstances different components of the intervention are likely to be effective, by conducting interviews and a focus group discussion (the Adaptation Phase). In the second phase, we will evaluate the feasibility of the FAST-M intervention (the Feasibility Assessment Phase).
Discussion

The utilisation of bundles can facilitate recognition and timely management of maternal sepsis. There is a need to adapt, integrate and optimise a bundled care approach in low-resource settings in Pakistan to minimise the burden of maternal morbidities and mortalities due to sepsis.
Initial Evidence of Aedes Albopictus (Diptera: Culicidae) Domiciliation in Havana City, Cuba 1995-2018.
Authors: Fernández María del Carmen Marquetti , Castillo Magaly , Peraza Iris , Milian Maricely , Molina Roberto , Leyva Maureen , Bisset Juan A. , Vanlerberghe Veerle
Published: November 2021

Background. Various arboviruses are transmitted to humans by mosquitoes, particularly Aedes aegypti and Aedes albopictus, two invasive and frequently sympatric species. The objective of this study was to evaluate the behavior of Ae. albopictus with regards to houses and association with other mosquitoes in Havana province. Methods. All deposits containing water in the houses and vacant lots of urban and peri urban municipalities of the province Havana were sampled during two periods: the first 1995 – 1999 and the second 2010-2018. Results. Patterns in the presence of Ae. albopictus in the study area were observed: the persistent absence of Ae. albopictus in one municipality; in two municipalities, starting from an absence in the first period to a rapid dispersion in the following period; and a sustained decrease in the dispersion of Ae. albopictus in two other municipalities. The association of Ae. albopictus with other mosquitoes smaller in the peripheral municipalities, although being the ones with the greatest presence of Ae. albopictus. However overall, we found an increase in this association when comparing the period 2010-2018 with the first period since its introduction in Havana. Inside the houses, Ae albopictus was present in 8% (2016) to 21.5% (2013) with an average of 15%, which evidences an initial domiciliation of the species.Conclusions. The results obtained in this work show an initiation of domiciliation of Ae albopictus in the urban area of Havana province. This is important to alert the National Control Program to strengthen the entomological monitoring of Ae. albopictus, and not only Ae. aegypti. The follow up of this domiciliation is important to guide control efforts, knowing its role as a vector of different arboviruses.
Membrane compartmentalization by adherens junctions creates a spatial switch for Notch signaling and function
Authors: Kwak Minsuk , Southard Kaden , Kim Woon Ryoung , Lin Annie , Kim Nam Hyeong , Gopalappa Ramu , An Minji , Lee Hyun Jung , Choi Seo Hyun , Farlow Justin , Georgakopoulos Anastasios , Robakis Nikolaos , Kang Min , Kutys Matthew , Seo Daeha , Kim Hyongbum Henry , Kim Yong Ho , Cheon Jinwoo , Gartner Zev , Jun Young-wook
Published: November 2021

Adherens junctions (AJs) create spatially and mechanically discrete microdomains at the interfaces of cells. Using a mechanogenetic platform that generates artificial AJs with controlled protein localization, clustering, and mechanical loading, we report that AJs also organize proteolytic hotspots for γ-secretase with a spatially-regulated substrate selectivity that is critical in the processing of Notch and other transmembrane proteins. Membrane microdomains outside of AJs exclusively organize Notch ligand-receptor engagement (LRE-µdomain) to initialize receptor activation. Conversely, membrane microdomains within AJs exclusively serve to coordinate regulated intramembrane proteolysis (RIP-µdomain). They do so by concentrating γ-secretase and primed receptors while excluding full-length Notch. AJs induce these functionally distinct microdomains by means of cholesterol-dependent γ-secretase recruitment and size-dependent protein segregation. By excluding full-length Notch from RIP-µdomains, AJs prevents inappropriate enzyme-substrate interactions and suppresses spurious Notch activation. Ligand-induced ectodomain shedding eliminates size-dependent segregation, releasing Notch to translocate into AJs for processing by γ-secretase. This mechanism directs radial differentiative expansion of ventricular zone-neural progenitor cells in vivo and more broadly regulates the proteolysis of large cell-surface receptors like amyloid precursor protein. These findings suggest an unprecedented role of AJs in creating size-selective spatial switches that choreograph γ-secretase processing of multiple transmembrane proteins regulating development, homeostasis, and disease.
To Study the Relationship between the Expression of MiR-21, MiR-155, Mir-182, and Mir-437 and Inflammatory Factors in the Cerebrospinal Fluid of Patients with Multiple Sclerosis
Authors: Karamad Vahidreza , Sogutlu Fatma , Abbasi Samane , shademan behrouz , Laghousi Delara , Nouri Mohammad , Hassanpour Mehdi , Nourazarian Alireza
Published: November 2021

Background: MicroRNAs (miRNAs) affect the differentiation and function of inflammatory cells. In addition, miRNAs can regulate the expression of pro-inflammatory genes in neuron cells. Therefore, the relationship between the expression of miRNAs and inflammatory markers in the cerebrospinal fluid of individuals with multiple sclerosis was investigated.Methods: RT-PCR determined the expression levels of MiR-21, MiR-155, Mir-182, and Mir-437 in CSF samples from patients with multiple sclerosis (MS) and the control group. The levels of the inflammatory cytokines IL -1β, IL -6, and TNF-α in CSF were measured by ELISA. The level of high-sensitivity C-reactive protein (hs-CRP) was measured by the quantitative turbidometric technique.Results: The expression of miRNAs and inflammatory factors were higher in the CSF of patients with MS than in the control group, and this difference was significant (P <0.05). The results of Receiver Operating Characteristics (ROC) analysis show that the area under the curve was obtained for miRNA-21 (AUC = 0.97, P <0.0001), miRNA-182 (AUC = 0.97, P <0.0001), and miRNA-155 (AUC = 0.96, P <0.0001). The highest rate of correct diagnoses of MS was associated with miRNA-155 in CSF. The relationship between inflammatory cytokines and miRNA-21, miRNA-155, and miRNA-182 was statistically significant, but there was an indirect and moderate correlation between miRNA-437 and hs-CRP, which were also statistically significant.Conclusion: Our results showed that the CSF levels of IL -1β, IL -6, TNF-α, and hs-CRP, and selected miRNAs, serve as biomarkers of central nervous system (CNS) inflammation and neurodegenerative processes in patients with MS.
Examining the impact of COVID-19 and its related lockdown on food security and job losses: A case of Kumasi, Ghana
Authors: Adusei Frank
Published: November 2021

The COVID-19 and partial lockdown has brought significant effects on the entire economy, especially on food security and job losses. This study was carried out in Asokwa Municipal with the objective of examining the impact of COVID-19 disease and its related lockdown on food and nutrition security and job losses. The study site form part of the cities in Ghana to experience the partial lockdown, hence it qualifies for the selection. Both primary and secondary data were used. By means of purposive sampling technique, fifty respondents were selected as sample size. The study employed a qualitative approach with a descriptive and narrative posture to the presentation, discussion and analysis of data. Open-ended questionnaire and a checklist were used for data collection through semi-structured interviews. The results revealed that, food and nutrition insecurity, job loss and income reductions are still very common, affecting participants livelihood. Disproportionally affected are households whose income comes from farming, transporters, informal labour, as well as marketers.It was concluded that food insecurity is not outside the impact of COVID-19 and its associated partial lockdown. Food and nutrition security are the global concern at present circumstances. The supply chain has been hit hardest by COVID-19, which causes food insecurity of most vulnerable segment of population which put them at risk. And also, most of the migrant, informal, seasonal farm workers were losing their jobs which may affect their demand for food. Therefore, the government should step-up the measures to control the pandemic without disturbing the food supply chain. The development and use of online marketing strategies where people can make orders of various produce and booked for purchases and or deliveries during a stated time range should be promoted.
Measures for correct design, manufacturing and exploitation of gear transmissions to increase the reliability
Authors: S S Ghimisi
Published: November 2021

Knowing the causes of product defects is very important in order to take the necessary measures in the design, manufacturing and service stages of the product. This paper presents the main solutions to be adopted to increase the reliability of gears. Gear mechanisms have many uses in machine building for their advantages. It is absolutely necessary to know the causes of damage to the toothed wheels and the measures to be taken to eliminate the defects. Technical literature present in many papers aspects of gear defects, causes of defects and measures to eliminate defects. This paper presents a modern method of quality management, called the tree diagram, applied to the issue of increasing the reliability of gear transmissions. The tree diagram made outlines the relationship between the overall goal pursued and the actions taken to achieve them. The tree diagram provides a picture of the potential solutions that can be adopted to avoid the two forms of gear failure: teeth breaking and damage to the active surface of the teeth flanks. This tool can be used in planning and solving quality assurance problems in the case of gear transmissions. The grouping of measures on the main objectives offers the possibility to focus specialists by focusing on the specific problems of each stage in the design, manufacturing and service of gear transmissions.
Analysis of using and operating conditions of the naval power equipment according to the waveinduced ship load
Authors: D. Iorgulescu
Published: November 2021

This article analyzes the conditions of operation and exploitation of the ship's power equipment using the meteorological conditions and the type of ship. Based on the naval power systems and new shipbuilding technologies,we are looking for optimization and increased reliability of shipboard automation and navigation systems that are on board. The article analyzes and presents solutions about the complex problems that arise in the work of the engineer that is on board. It is demonstrated the importance of the quality indicators of the naval power system for improving the operating conditions of the existing plants and to modernize the ship by providing new equipment and computers whose optimal working is influenced by the quality of the electrical energy that is onboard. In this paper it is followed the ranking of the implemented control, monitoring and protection of the electrical energy system and the propulsion power of the systems, in which the physical and functional integrity is a vital design philosophy. This can be centralized or distributed by the computers. The study of the waves is done in order to estimate the induced demands in the structure of the ship and their influence on the equipments and the devices that are on-board. The analysis is performed using experimental and theoretical values as input data in the analysis with finite elements. For the estimation of structural strength of the ship and on-board equipment it is necessary to determine the extreme values of the wave-induced loads
Vibro-acoustic airport and port modeling process
Authors: A Crețu
Published: November 2021

The article presents process of modeling and generating noise contours and focuses on how to calculate aerodynamic noise levels around ports and airports. In order to have information about the magnitude and magnitude of the impact caused by aircraft noise around airports / ports, maps that have marked outline contours are needed. A noise contour is generated by the mathematical calculation of the areas where there are noise indices and is marked by a line along which the index value is constant. Calculation of the value of the noise index is made by summing up all the acoustic events caused by the aircraft (individual) occurring over a period of time, normally expressed in days or months.
Contributions to the study of service characteristics of marine fuels
Authors: L Ali
Published: November 2021

Since the beginning, development of marine diesel engines was turned towards obtaining a low fuel consumption and the result has reflected in engines construction: increased bore and cylinder liner diameter, higher working pressures and lower piston speeds. Similar improvements have taken place in the supercharging system, innovative fuel injection technologies and changes in combustion pressures. Nowadays, the trend of development has changed, the concept of reducing NOx and SOx emissions became a priority in order to meet the limits imposed by international organizations. As a consequence, a series of changes in operating mode of marine engines was noticed but also several innovations appeared in the construction and development of marine engines.
Non-intrusive Embedded Systems Anomaly Detection using Thermography and Machine Learning
Authors: Oliveira José Paulo , Bastos Filho Carmelo José Albanez , Oliveira Sérgio Campello
Published: November 2021

Quality control in electronic system manufacturing is achieved mainly through system testing. Device miniaturization and multilayer Printed Circuit Boards have increased the electronic circuit test complexity considerably and processes based on manual inspections have become outdated and inefficient. The concept of Industry 4.0 has enabled the manufacturing of customized products based on customers’ demands, which demands a high degree of flexibility in production processes, with low cost and without placing numerous test points. In this paper, we propose two automated test solutions based on machine learning and thermographic analysis. We propose deploying autoencoders and random forest in two different manners to detect firmware or hardware anomalies based on the circuit board’s temperature signature. We validate our proposal using two firmware versions running independently on the test board. We obtained an anomaly detection rate above 98%. In the random forest approach, we require all data classes for training, whereas the autoencoder only requires the reference class, which is expected in real scenarios.
La función mediadora de la capacidad absortiva en la relación entre el capital intelectual y la innovación en los institutos de educación superior del sur de Tamaulipas
Authors: Nahuat Román Bernardo , Rodríguez Vargas Miriam , Gómez de la Fuente Ma. del Carmen
Published: November 2021

Introducción: en la actualidad, la innovación en las organizaciones es demandada de una forma sin precedentes. Si bien el capital intelectual (CI) ha sido señalado como uno de sus detonadores, un paso adelante es entender el rol que tienen otras variables en esta relación. Por lo anterior, el objetivo principal de la presente investigación es determinar la función mediadora de la capacidad absortiva (CA) en la relación entre el CI y la innovación organizacional en institutos de educación superior del sur de Tamaulipas.
Método: de los 31 institutos de educación superior existentes en el sur de Tamaulipas se seleccionaron aquellos que tienen menos de 50 empleados, reduciéndose a 27 escuelas. En estas instituciones se aplicaron 92 cuestionarios a docentes en el primer semestre del año 2020 para, posteriormente, aplicar un modelo de ecuaciones estructurales con la técnica PLS.
Resultados: la evidencia confirma la función mediadora de la CA en la relación entre el CI y la innovación organizacional. Así mismo, los resultados permiten observar un efecto positivo y significativo de las variables CI y CA sobre la innovación organizacional.
Discusión: el resultado amplía el conocimiento de la función mediadora que tiene la CA en la relación entre el CI y la innovación organizacional; de la misma forma, sugiere que, en la medida en que se pueda controlar este efecto de la CA, se podría favorecer la innovación.