bluuebunny/crossref_metadata_2025 huggingface dataset:
State Relations with Churches and Other Religious Organizations in Poland – Proposals for Changes after the Parliamentary Elections in 2023
Authors: Matwiejuk Jarosław ,   University of Bialystok
Published: July 2024

Goal – the purpose of this study was to present proposals for changes in the state’s relations with religious organizations in Poland after the parliamentary elections in 2023. Research methodology – the draft laws and literature on this topic have been thoroughly analyzed for the purpose of this article. Score/results – the article showed that there are projects for changes in the state’s relations with religious organizations in Poland after the parliamentary elections in 2023. Originality/value – the article expands knowledge about the planned changes in the legal situation of religious associations in Poland.
Direct Foreign Investment in the Central and Eastern European Countries in the Period of Political and Economical Destabilization
Authors: Owczarczuk Magdalena ,   University of Bialystok, Wierzbicka Anna ,   University of Bialystok
Published: July 2024

Goal – the main research query of the article regards whether the tendencies and mobility in the sphere of the FDI inflow to the CCEEs changed, in the existing conditions of the political and economic instability. Therefore, the purpose of the article is to evaluate the changes in the FDI level, dynamics and structure in the CCEEs in the conditions of geopolitical uncertainty resulting from the outbreak of the war in Ukraine, in comparison with the tendencies in the previous years. Research methodology – the first part of the article contains the analysis of the overview of the literature on the FDI conditioning in the CCEEs (the Czech Republic, Estonia, Hungary, Lithuania, Latvia, Poland, Slovakia and Slovenia) and the evaluation of the investment attractiveness in the light of the selected factors. The next part contains the analyses concerning the capital inflow in the form of FDI to the CCEEs which included the data regarding the FDI resources, the FDI recourses per capita, FDI inflow, including the number and value of greenfield investments. The analysed period covers the years 2012–2022. Score/results – when analysing the basic macroeconomic indicators characterising the economic conditions of CCEEs, it may be stated that those countries follow an economic development path where FDI has an important role. The inflow of foreign direct investment played a crucial role both in the transformation process of CCEEs’ economies and also influences their modernisation and development now. Originality/value – considerations and analyses conducted in the article allow to claim that geopolitical destabilisation affected the economies of the CCEEs, including the inflow of capital in the form of FDI, in two ways. On the one hand, it may be observed that those countries, as well as other countries in Europe, experienced deterioration of the economic conditions. Lower dynamics of the GDP growth and high inflation are typical problems of the analysed economies. However, despite that, the investment attractiveness of those countries remains high. The analysed economies constitute attractive locations for foreign investment, which is confirmed by the growing FDI inflow, the growing value of FDI per capita, or the growing value of greenfield projects.
Crowdfunding as a Tool to Spread Good Attitudes in the Media and Support in Shaping Values in Human Life on the Example of the Production of the Film ABP Lefebvre – Why?
Authors: Pangsy-Kania Sylwia ,   University of Gdansk
Published: July 2024

Goal – the research goal was to demonstrate the role of crowdfunding in the production of the analyzed film. Two theses result directly from the research goal and were formulated as follows: 1) Crowdfunding in the production of the film ABP Lefebvre – Why? is not the main source of financing; 2) The benefit of crowdfunding is the spread of good attitudes in the media and support in shaping values in human life and proclaiming the Catholic truth. Research methodology – the study uses descriptive research, which is an important stage of cognition because it creates an objective picture. The meaning of crowdfunding was preceded by a characterization of values in human life. As a part of the research methodology, the author of the article used the following research techniques as data collection methods: desk research, case study and an individual in-depth interview conducted with the film producers as part of the Filmowe Życiorysy PL project. Score/results – presentation of the importance of crowdfunding on the example of the production of the film ABP Lefebvre – Why? Crowdfunding can result in realizing many valuable and substantive projects, e.g. obtaining funds necessary for the production of a film, while engaging the community for which the subject of the film is important. However, crowdfunding was not the main source of financing in the case of the film ABP Lefebvre – Why?, it did not even constitute the majority share in the costs. Originality/value – the film about the archbishop is undoubtedly entering into the center of the hottest disputes in the Church, but also an opportunity to understand them better. This topic is rarely discussed in the literature. The paper covers both advantages and benefits and disadvantages and threats of crowdfunding as a tool to spread good attitudes in the media and the support in shaping values in human life. Crowdfunding, which enables partial financing of the film production of an important biography, has the potential to become a specific tool that brings people closer to God.
International Tax Competitiveness: Between TAX Optimization and Tax Fairness
Authors: Sosnowski Michał ,   Wroclaw University of Economics and Business
Published: July 2024

Goal – this work aims to examine tax competition between countries and the balance between tax optimization and tax fairness. The study focuses on the impact of tax competition on the allocation of foreign investment, capital mobility and the competitive advantage of the economy in the international arena, as well as on the analysis of entrepreneurs’ motivation for tax optimization and its effects on public revenues and tax fairness. Research methodology – the research methodology works on a review of the scientific literature on tax competition, tax and tax optimization. These criteria are analysed on the basis of the analysis of determinants of tax competitiveness and the interaction between tax policy and the economic sphere. Score/results – the results of the analysis of the literature synthesis confirm that the increase in tax competition between countries leads to the transfer of investment allocations and, in the end, contributes to the growth of the competitive advantage of the economy on the international arena. Entrepreneurs seeking tax optimization choose a jurisdiction with the effectiveness of tax applications, and the application has an impact on public revenues and on achieving tax justice. Originality/value – the added value of this work is a new perspective on tax competitiveness and the related issues of tax optimization and tax fairness. The work also includes recommendations for policy makers, businesses and society.
Epigenetics in thyroid cancer: a bibliometric analysis
Authors: Li Hui , Wu Peng
Published: July 2024

Background

Epigenetics, which involves regulatory modifications that do not alter the DNA sequence itself, is crucial in the development and progression of thyroid cancer. This study aims to provide a comprehensive analysis of the epigenetic research landscape in thyroid cancer, highlighting current trends, major research areas, and potential future directions.

Methods

A bibliometric analysis was performed using data from the Web of Science Core Collection (WOSCC) up to 1 November 2023. Analytical tools such as VOSviewer, CiteSpace, and the R package ‘bibliometrix’ were employed for comprehensive data analysis and visualization. This process identified principal research themes, along with influential authors, institutions, and countries contributing to the field.

Results

The analysis reveals a marked increase in thyroid cancer epigenetics research over the past two decades. Emergent key themes include the exploration of molecular mechanisms and biomarkers, various subtypes of thyroid cancer, implications for therapeutic interventions, advancements in technologies and methodologies, and the scope of translational research. Research hotspots within these themes highlight intensive areas of study and the potential for significant breakthroughs.

Conclusion

This study presents an in-depth overview of the current state of epigenetics in thyroid cancer research. It underscores the potential of epigenetic strategies as viable therapeutic options and provides valuable insights for researchers and clinicians in advancing the understanding and treatment of this complex disease. Future research is vital to fully leverage the therapeutic possibilities offered by epigenetics in the management of thyroid cancer.
Induction of the intestinal membrane transporters ABCA1 and ABCG8 by 27-hydroxycholesterol through a redox mechanism
Authors: Iaia Noemi , Leoni Valerio , Poli Giuseppe , Biasi Fiorella
Published: July 2024

Graphical abstract

Redox-induction of expression and synthesis of ATP binding cassette transporters in CaCo-2 cells by externally added 27-hydroxycholesterol.

27OHC: 27-hydroxycholesterol; NOX: NADPH oxidase; ROS: reactive oxygen species; ABCA1: ATP binding cassette A1; ABCG8: ATP binding cassette G8; DPI: diphenylene iodonium.

Objective

We tested the effect of 27-hydroxycholesterol (27OHC) on the expression and synthesis of two membrane transporters involved in sterols extrusion from the intestinal epithelium into the gut lumen: ATP-binding cassette A1 (ABCA1) and G8 (ABCG8). Special attention was given to ABCG8, a key player in the intestinal cell discharge of plant sterols.

Methods

Differentiated CaCo-2 intestinal cells were supplemented with 27OHC, and added to the cell incubation medium at a final concentration of 1 or 5 µM. These 27OHC externally added amounts were proven to reach intracellular oxysterol levels within the range of those normally recovered in the human peripheral blood.

Results

An up-regulation of the ABCA1 and ABCG8 mRNAs was observed in the CaCo-2 cells supplemented with 27OHC. Moreover, both 1 µM and 5 µM 27OHC induced a net, and steady, statistically significant, increase of both ABCA1 and ABCG8 protein levels. Of interest, the cellular pre-treatment with diphenylene iodonium, a selective inhibitor of NADPH oxidase, i.e. a major intracellular source of reactive oxygen species, fully inhibited the 27OHC enhancement of both ABCA1 and ABCG8 protein synthesis.

Conclusion

This in vitro study shows for the first time that the addition of 27OHC to intestinal epithelial cells up-regulates ABCG8, the transporter discharging plant sterols into the gut lumen, besides confirming to induce ABCA1 as well. Importantly, the 27OHC-dependent up-regulation of the two transporters appears to involve a redox mechanism rather than the canonical liver-X-receptors-dependent pathway.

Significance statement

The 27OHC introduced with the diet might modulate the plant sterol extrusion in the gut, in parallel with that of cholesterol.
Redes de productores-consumidores como impulsores de la transición hacia la sostenibilidad en contextos rurales. Dos casos de Costa Rica
Authors: Avendaño Leadem Daniel , Schmeiduch Lena , Bruno Nuñez Orlando , Betzler Shirin
Published: July 2024

Successful sustainability transitions are crucial to answer to ongoing crises. Focusing strongly on biocultural heritage, local customs, and traditions, as well as the natural environment and landscape aesthetics, rural regions have great potential to promote sustainable development and growth. This sustainable development of rural regions further contributes not only to local, but also to national and supranational development by strengthening sustainable economic growth, alleviating unemployment, and poverty, and improving living conditions. Local entrepreneurs are continuously included in discussions on sustainability transitions in rural regions as an important driver through their innovative entrepreneurial activities. By comparing two example regions within rural areas of Costa Rica - the Dota and Turrialba region - the role of these entrepreneurial endeavors is illustrated. For this purpose, we exemplify how both regions contribute to rural, sustainable development based on their geographical, entrepreneurial, and collective characteristics. Specifically, the role of entrepreneurs’ specific mind- and skillset, their embeddedness in producer-consumer-networks and the encompassing geographical context is investigated. Implications on the different levels of analysis are drawn in terms of learning opportunities for both, the respective included regions, as well as supra-regional development in a broader sense. The sCoRe project is presented as an exemplary initiative designed to foster collaboration between rural entrepreneurs and academic initiatives to enhance local producer-consumer-networks, and thus contribute to the establishment of sustainable communities.
El avizinhar en la consolidación del concepto de extractivismo en la amazonia acreana, Brasil
Authors: Dourado da Silva Rachel , Frejomil Enrique Propin
Published: July 2024

The work consists of a historical-geographical reconstruction, using the popular orkers avizinhar in the consolidation of the orkers Extractivism in the Acrean Amazon. The methodology is based on bibliographic analysis, documents, fieldwork, interviews, public domain images. Extractivism developed throughout history throughout the world, with orkers biases: as na activity that has its action linked to na unprecedented extraction of elements of nature, extraction without due concern for orkers damage or the absence of such elements in the composition of the ecosystem. However, the orkers work seeks to orkers and conceptualize extractivism from the experience of the Amazon, in particular the Brazilian state of Acre that, despite complying with the etymology of the word, “withdrawal, collection of materials from nature”, transcends predatory extraction, and reverts into struggles for the conservation of nature and human lives that inhabit the forests. These actions were led by Chico Mendes in the mid-1980s through the union organization of forestry orkers initiated in the 1970s.
Full Outline of UnResponsiveness (FOUR) Scale: a Multicenter Validation Study of the Psychometric Properties of the Approved Russian Version
Authors: Piradov M. A. , Suponeva N. A. , Yatsko K. A. , Yusupova J. G. , Zimin A. A. , Legostaeva L. A. , Yazeva E. G. , Domashenko M. A. , Samorukov V. Y. , Belkin A. A. , Kondratieva E. A. , Kondratiev S. A. , Ramazanov G. R. , Kovaleva E. A. , Popugaev K. A. , Petrikov S. S. , Ryabinkina Yu. V.
Published: July 2024

Assessment of the individual level of consciousness on admission of a patient with brain injury to the intensive care unit (ICU) is a priority task and a mandatory step in the overall assessment of neurological status. The Full Outline of UnResponsiveness (FOUR) scale, developed at the Mayo Clinic (USA) in 2005, is a widely used tool for comprehensive assessment of patients with altered state of consciousness. The lack of a validated Russian-language version of the FOUR scale has hindered its widespread use in clinical practice. Therefore, the official Russian version of the FOUR scale was developed and adapted for use in Russia after the first stage of the validation study (linguistic and cultural adaptation).

Aim. To evaluate the psychometric properties of the Russian version of the FOUR scale for comprehensive assessment of patients in altered state of consciousness.

Materials and Methods. As part of a prospective multicenter validation study, the psychometric properties of the scale (reliability, validity, and sensitivity) were evaluated in a group of 171 adult patients with altered conscious state of various etiologies, such as ischemic and hemorrhagic stroke, neuroinflammatory conditions, and traumatic brain injury. Patients’ responses were assessed on the first day of ICU stay and 2-3 days later by two ICU neurologists with at least three years of experience.

Results. High levels of validity and reliability were obtained for the Russian version of the FOUR scale for comprehensive assessment of unresponsive patients, including Spearman’s rank correlation coefficient r=0.99 (P<0.0001), Cohen’s κ=0.77 (P<0.001), Cronbach’s α=0.87 (P<0.0001). Regarding the sensitivity of the FOUR scale, no significant changes were found after comprehensive assessment of unresponsive patients on day 1 in the ICU and 2-3 days later (Wilcoxon test, P=0.906). There was a good correlation between the FOUR and Glasgow Coma Scale scores used to assess patients with altered state of consciousness, confirming the validity of the test with r=0.91 (P<0.0001).

Conclusion. The Russian version of the FOUR scale for comprehensive assessment of unresponsive patients is a valid, reliable, and sensitive clinical tool. Sufficiently verified level of psychometric properties allows its authorized use in Russia and other Russian-speaking countries. The scale is available for download via QR code and at the website of the International Scales and Questionnaires Validation Group at the Scientific Center of Neurology.
Sosnovskio barščio (Heracleum sosnowskyi Manden.) paplitimas ir kontrolė Klaipėdos rajone
Authors: Markaitytė Eglė
Published: July 2024

Kiekvienais metais yra užregistruojama naujų nepageidaujamų augalų augimviečių. Lietuvoje labiausiai žinomas invazinis augalas – Sosnovskio barštis (Heracleum sosnowskyi Manden.) – yra paplitęs ir Klaipėdos rajone. Jo gausūs sąžalynai pakeičia augalų bendrijų rūšių struktūrą, ypač pievų buveinėse. Be to, šis augalas kelia grėsmę žmonių sveikatai bei kenkia ūkiniams gyvūnams. Lietuvoje Sosnovskio barštis masiškai naikinamas, visgi pasirinktas tinkamas kontrolės būdas galėtų užtikrinti ilgalaikį rezultatą, kuris neleistų šiam augalui plisti. Straipsnyje pristatomo tyrimo tikslas – palyginti Sosnovskio barščio naikinimo Klaipėdos r. savivaldybės teritorijose rezultatus: vienose jų trejus metus Sosnovskio barštis buvo intensyviai naikintas, o kitose – tik vykdyta minimali šio invazinio augalo kontrolė. Tyrimo rezultatai parodė, kad Sosnovskio barščio naikinimas mechaniniais ir cheminiais metodais yra efektyvesnis nei tik invazinio augalo šienavimas. Pateiktos rekomendacijos leis atidžiau rinktis kontrolės priemones Sosnovskio barščio plitimo rizikai sumažinti.
Metal oxides for electronics and the SPQEO journal
Authors:   V. Lashkaryov Institute of Semiconductor Physics NAS Ukraine 41 Nauky Avenue, 03028 Kyiv, Ukraine, Belyaev A. , Maksimenko Z. ,   V. Lashkaryov Institute of Semiconductor Physics NAS Ukraine 41 Nauky Avenue, 03028 Kyiv, Ukraine, Smertenko P. ,   V. Lashkaryov Institute of Semiconductor Physics NAS Ukraine 41 Nauky Avenue, 03028 Kyiv, Ukraine
Published: July 2024

This article discusses the main trends in the physics and preparation of metal oxides and summarizes the results of research published by SPQEO in this area over the past decade. The main metal oxides studied include ZnO, Zn1-xCdxO, Zn1-xCoxO, MgxZn1–xO, ZnO:Mn, VO2, ZrO2–Y2O3, TiO2, WO3, Gd2O3, Er2O3, WO3–CaO–SiO2–B2O3: Tb3+, Dy2O3, NiO, FexOy, Ga2O3, Al2O3, ITO, Ag2O and graphene oxide. These oxides were obtained by the following methods: sintering in air or in a stream of various gases, magnetron sputtering, atomic layer deposition, explosive evaporation, sol-gel, spin coating, spray pyrolysis, rapid thermal annealing, green synthesis from plant solutions, melt quenching, rapid thermal annealing, self-ignition, ion-plasma co-sputtering, vacuum sputtering, reactive ion beam sputtering, and the Hammer method. The electrical and optical properties of the studied oxides are illustrated.
Attitudes towards the languages ​​of Ukrainians of various ethnic origins during the full-scale war
Authors: Hontar Maryna ,   Institute of the Ukrainian Language of the National Academy of Sciences of Ukraine
Published: July 2024

The article reveals the peculiarities of attitudes towards the Ukrainian and Russian languages by Ukrainians of different ethnic origins based on their language biographies. It has been shown that attitudes towards language are dynamic. They have been forming and changing throughout a person’s life, primarily under the influence of such factors as social and historical events, language environment, education, close people, and psychological aspects. The language biography of an Azerbaijanian male illustrated the effect of the language environment and close people on his attitude towards the Ukrainian language. The language biographies of female respondents of Russian origin, as well as a female respondent of Armenian-Ukrainian origin with Russian as her mother tongue, demonstrated the influence of education, psychological and socio-political factors (The Revolution of Dignity 2013—2014, the Russian war against Ukraine (since 2014), and the full-scale invasion in 2022). Attitudes toward languages are linked to the socio-political circumstances in which a person lives. The environment or events affect a person’s emotions, which in turn influence attitudes toward languages. Representatives of the Russian ethnic group are experiencing a difficult time during the Russian aggression in Ukraine. They have an internal conflict; on the one hand, they are beginning to use the Ukrainian language more, but on the other hand, Russian continues to be part of their ethnic identity and the dominant language of communication. At the same time, we see different levels of rejection of everything related to the Russian aggressor: condemnation of the aggressor’s actions, refusal of Russian literature, and language shift from Russian to Ukrainian. Keywords: language attitudes, sociolinguistics, bilingualism, Ukrainian, Russian, Russian war against Ukraine.
Religious-Sociocultural Networks and Social Capital Enhancement in Pesantren
Authors: Sutomo Sutomo , Musnandar Aries , Alzitawi Diaya Uddeen Deab Mahmoud , Sutrisno Sutrisno
Published: July 2024

Implementing society empowerment models is crucial for addressing micro-level problems where government services often fall short. Despite evidence that social capital significantly contributes to development and poverty reduction, there remains a gap in understanding specific strategies and outcomes of social capital-based empowerment initiatives. This study aims to fill this gap by investigating the unique learning concept of Pesantren Rakyat Sumberpucung (PRS), which emphasizes low- cost, independent, flexible, and mutual assistance principles. Utilizing framework which includes structural opportunity to meet, know-how of social interaction, sense of belonging, and ethos of mutuality, this study employed qualitative research design. Data were gathered through participant observation, semi-structured interviews with village-level stakeholders, in-depth interviews and focus group discussion. The results indicate that the integrative model known as "Pancarukun," which includes initiatives such as Jagong Mathon, Celengan, Ngaji Ngluruk, Lumbung Pesantren Rakyat, and Fatehahan, effectively strengthens socio-cultural-religious networks, fostering harmony and cooperation between PRS and the community. These strategies have successfully promoted a spirit of togetherness and consistent collaboration. In conclusion, PRSâ€™s approach demonstrates the potential of integrative community-based strategies to address diverse problems across sectors such as economy, agriculture, education, and culture. By leveraging social capital, PRS has created a sustainable model of community empowerment that can serve as a blueprint for similar initiatives.
Empowering Educational Autonomy to Implement Kurikulum Merdeka in Madrasah
Authors: Ainissyifa Hilda , Nasrullah Yufi Mohammad , Fatonah Nurul
Published: July 2024

This study investigated the pivotal role of education management in the implementation of the Kurikulum Merdeka (KM) within Madrasah institutions. Grounded in Terry's management functions theory, the research discerns both the facilitating factors and obstacles encountered during the curriculum implementation. Employing qualitative methodologies, including interviews with madrasah heads, teachers, and students, alongside curriculum document analysis, the study unfolds crucial insights. The findings underscore the indispensable nature of effective education management across the phases of planning, execution, and evaluation of the KM Supportive elements encompass stakeholder engagement, provision of adequate facilities, and the adoption of flexible learning methodologies. Conversely, significant challenges emerge, such as the imperative for enhanced comprehension of KM and the necessity for gradual readiness in its implementation. This research extends its contribution by delineating actionable strategies to surmount these obstacles, thereby furnishing guidance for madrasahs and other educational institutions in navigating KM implementation. These insights hold promise for enhancing the efficacy of curriculum deployment at the madrasah level, while also paving the way for further exploration within the Indonesian educational landscape.
The Role of Steam Education in Improving Student Collaboration and Creativity: A Case Study in Madrasah
Authors: Zaqiah Qiqi Yuliati , Hasanah Aan , Heryati Yeti
Published: July 2024

The 21st century is marked by increasing technological progress and productivity. This progress has provided a challenge for the education sector to produce quality young people with adequate skills. This research examines the effectiveness of a learning approach that integrates a multi-subject called STEAM, namely science, technology, engineering, arts and mathematics, to improve 21st-century skills. These skills include collaboration, creativity, critical thinking and communication, known as the 4Cs. As a case study, this STEAM learning was given to students at two State Madrasahs in West Java. To achieve this goal, mixed methods were used. The research combined qualitative and quantitative approaches. A qualitative approach was used to observe phenomena experienced by students, learning design, and implementation. Moreover, a quantitative approach was used to analyze the impact of STEAM learning on student skills. The STEAM learning design was delivered in three learning meetings. Research findings show that the STEAM learning model by using a multi-subject approach could significantly improve students' collaboration skills. However, it did not significantly improve studentsâ€™ critical thinking, creativity and communication skills. Meanwhile, student responses showed positive results on the implementation of this model. Factors that were considered to influence the implementation of this model are: Duration of learning, literacy skills and student learning experiences, as well as teacher competencies.
Promoting Islamic Value for Green Skill Development in Islamic Vocational High School
Authors: Fauziah R. Siti Pupu , Purnomo Agustina Multi , Firdaus Uus , Dani Nanyanto Asep Bayu , Roestamy Martin
Published: July 2024

Air pollution is a critical issue in Indonesia in 2023, prompting the need to enhance green skills within Vocational High Schools to support a sustainable green economy. The purpose of this study is to investigate the influence of Islamic values on the development of green skills among students. Utilizing quantitative methods, data were collected through online questionnaires distributed to 562 twelfth-grade students at the Islamic Foundation Vocational School in Bogor Regency. The results revealed that Islamic values, particularly beliefs and attitudes towards the environment, significantly impacted the acquisition of green skills. Further analysis identified that Islamic values as a source of inspiration and serenity, along with teachings on tree planting and zero-waste practices, had a partially significant effect. The study concludes that incorporating Islamic religious education into the vocational school curriculum is crucial. These findings offer valuable insights for educators, policymakers, and practitioners, providing a basis for integrating Islamic values into vocational education to enhance green skill development among students.
Jolkinolide B attenuates allergic airway inflammation and airway remodeling in asthmatic mice
Authors: Lin Haiyan , Xu Chao , Ge Jintong , Wu Hua , Wang Qi
Published: July 2024

Asthma is a widely prevalent chronic disease that brings great suffering to patients and may result in death if it turns severe. Jolkinolide B (JB) is one diterpenoid component separated from the dried roots of Euphorbia fischeriana Steud (Euphorbiaceae), and has anti--inflammatory, antioxidative, and antitumor properties. However, the detailed regulatory role and associated regulatory mechanism in the progression of asthma remain elusive. In this work, it was demonstrated that the extensive infiltration of bronchial inflammatory cells and the thickening of airway wall were observed in ovalbumin (OVA)-induced mice, but these impacts were reversed by JB (10 mg/kg) treatment, indicating that JB relieved the provocative symptoms in OVA-induced asthma mice. In addition, JB can control OVA-triggered lung function and pulmonary resistance. Moreover, JB attenuated OVA-evoked inflammation by lowering the levels of interleukin (IL)-4, IL-5, and IL-13. Besides, the activated nuclear factor kappa B (NF-κB) and transforming growth factor-beta–mothers against decapentaplegic homolog 3 (TGFβ/smad3) pathways in OVA-induced mice are rescued by JB treatment. In conclusion, it was disclosed that JB reduced allergic airway inflammation and airway remodeling in asthmatic mice by modulating the NF-κB and TGFβ/smad3 pathways. This work could offer new opinions on JB for lessening progression of asthma.
Unveiling the anti-tumor and anti-fibrotic potentials of Kanglaite in esophageal cancer through PVT1/TGF-β/Smad axis inhibition
Authors: Li Xiuqing , Bian Ka , Zhang Ji , Luo Kaili , Dong Tao , Luo Chenglin
Published: July 2024

Esophageal cancer (EC) poses a significant challenge among tract tumors worldwide due to its complex molecular composition, which remains largely unexplored. Kanglaite (KLT), a medicine known for its anti-tumor properties, is emerging as a potential ally in the culinary world. Plasmacytoma Variant translocation 1 (PVT1) plays a significant role in the complex nature of esophageal cancer, showing high expression levels in tumor tissues. During our investigation, we discovered a higher presence of PVT1 in cancer tissues, which led us to explore its functions further. Through manipulating techniques, we found that inhibiting PVT1 not only hinders the growth of esophageal cancer cells but also reduces fibrosis. This is similar to enhancing the texture and flavor of a dish. Our study reveals the interactions at play, highlighting how PVT1 orchestrates the TGF β/Smad pathway – a component in the development of esophageal cancer. Introducing KLT, an expert poised to revolutinize the approach to cancer treatment. Our research demonstrates KLT’s effectiveness in regulating the PVT1/TGF-β/Smad axis, uncovering its fibrotic properties, and its ability to hinder the progression of esophageal cancer. With these discoveries, KLT emerges as a promising option for the treatment of esophageal cancer.
Dianov Fiber Optics Research Center became 30 years
Authors:   Dianov Fiber Optics Research Center, Tomashuk Alexander L. , Semenov Sergey L. ,   Dianov Fiber Optics Research Center
Published: July 2024

The main achievements and milestones in the development of the Dianov Fiber Optics Research Center - branch of Prokhorov General Physics Institute of the Russian Academy of Sciences.
Mechanical testing of optical fibers in the gigacycle fatigue regime
Authors:   Institute of Continuous Media Mechanics of the Ural Branch of Russian Academy of Science, Bannikov Mikhail Vladimirovich , Vshivkov Aleksei Nikolaevich ,   Institute of Continuous Media Mechanics of the Ural Branch of Russian Academy of Science, Gachegova Elena A. ,   Institute of Continuous Media Mechanics of the Ural Branch of Russian Academy of Science, Trefilov I.A. ,   Perm State National Research University, Kondrashov A.N. ,   Perm State National Research University, Sozonov Nikolay S. ,   Perm State National Research University
Published: July 2024

The active application of composite smart materials, which include, in addition to the main material carrying the strength load, optical fibers with optic sensors for condition monitoring, makes the task of determining the strength of the fiber optic sensors itself urgent. Such a task is especially acute in systems subjected to long-term alternating (fatigue) loading, when irreversible damage begins to accumulate in the material. This paper shows a method for determining the fatigue life of specialized optical fibers with Bragg gratings in the so-called gigacycle fatigue regime, when the material resists cyclic loading for more than 10^9 cycles.
High-speed optical channels of advanced optical transport networks OTN/DWDM
Authors:   T8 LLC, Kogan S.S. , Naniǐ Oleg E. ,   T8 LLC, Treshchikov Vladimir N. ,   T8 LLC
Published: July 2024

The series of articles presents analytical materials on the throughput and evolution of modulation formats for OTN/DWDM FOTS optical channels; in terms of communication range, spectral efficiency and symbol rate of OTN/DWDM FOTS optical channels.
Modeling of fiber-optic vibration sensor based on attached bragg grating
Authors:   Perm State National Research University, Safaryan K.A. , Goldobin A.A. ,   Perm State National Research University, Trefilov I.A. ,   Perm State National Research University, Goncharov M.M. ,   Perm State National Research University
Published: July 2024

The article presents a numerical analysis of the possibility of creating a fiber-optic vibration sensor based on an attached Bragg grating. The sensor consists of two inert masses connected to each other by several membranes and an optical fiber with a fiber Bragg grating (FBG). The study is divided into two main stages: modeling the mechanical part of the sensor, assessing cross-influence and the influence of external temperatures, and developing a signal processing algorithm. A mechanical study of the vibration sensor was conducted to determine its resonant frequency and to determine the optimal length of the elastic beam. The optical part of the study focused on selectingoptimal parameters for the configuration of the arrangement of optical fibers. The results showed that the sensor has its own oscillation frequency above 2000 Hz, and there is a weak dependence of the sensor's sensitivity on the frequency of oscillations with a beam length of 1 mm. The research contributes to the development of fiber-optic accelerometers for measuring and analyzing vibration in various application areas.
Effectiveness of Bradyrhizobium japonicum inoculation on nodulation dynamics in Glycine max (L.) roots
Authors: MILADINOVIĆ Vladimir , POPOVIĆ Vera M. , DELIĆ Dušica , DAJIĆ STEVANOVIĆ Zora , KIPROVSKI Biljana , KOLAŠINAC Stefan , MIKULIC-PETKOVSEK Maja , UGRENOVIĆ Vladan
Published: July 2024

Bradyrhizobium japonicum bacteria on the intensity of nodulation during nine phenophases (R1-R7) in relation to the isoflavone content in soybean seeds. Nine domestic soybean varieties were sown in three replicates, with Bradyrhizobium japonicum inoculated and non-inoculated seeds. The different morphological characteristics of nodules, the number and mass of nodules were studied during plants’ ontogenesis. The content of individual isoflavones in the sowing seed material was determined using high performance liquid chromatography mass spectrometry (HPLC-MS). The most abundant isoflavone was acetylgenistin in the variety Galeb (2741.4 μg/g), and the highest content of all isoflavones was recorded in the variety Gorštak (8117.7 μg/g). The variety Sava of the inoculated treatment exhibited the highest average values of the nodule mass (21.1 mg) and the highest number of nodules (23.3) in the phenophase, in which 10% of pods reached full length (R4). The average values of mass and number of nodules were calculated for the entire vegetation period, being higher in the inoculated treatment. There was no positive correlation between the content of isoflavones in seeds and the number and mass of nodules. The impact of quantity of isoflavone on nodulation intensity in soybeans was not significant,, which could be related to already saturated soil with nitrogen-fixing bacteria.
Titanium dioxide nanoparticles (TiO2-NPs) effect on germination and morphological parameters in alfalfa, tomato, and pepper
Authors: ACOSTA-SLANE Damaris , GONZÁLEZ-FRANCO Ana Cecilia , HÉRNANDEZ-HUERTA Jared , CASTILLO-MICHEL Hiram , REYES-HERRERA Juan , SÁNCHEZ-CHÁVEZ Esteban , VALLES-ARAGÓN María C.
Published: July 2024

Titanium dioxide nanoparticles are used in different processes, derived from this their presence in wastewater is common, concentrating in residual sludge. These residues are used as agricultural soil improvers, being a source of crop exposure. In this study, the effect of TiO2-NPs (450, 900, and 1800 mg L-1) on the germination of alfalfa, tomato, and pepper seeds was evaluated. The germination parameters were not different (p > 0.05) except for, the seed vigor index in alfalfa and pepper, and the mean germination time in tomato. The germination index was below 80% in 450 mg L-1 in tomato, which showed moderate phytotoxicity. Morphological modifications with differences (p < 0.05) were found in the three crops, mainly in the root. In tomatoes, the length of the main root, root hairs, and the width of the root tip were reduced but increased the width of the main root, piliferous zone, and the length of root hairs were. For alfalfa, root length and number of secondary roots augment. However, the stem, root tip width, and root villi were reduced. Finally, for pepper, the length, and width of the root and the piliferous zone were modified. Additionally, a concerning trend has been observed in the length of root hairs. TiO2-NPs affected germination and morphology in alfalfa, tomato and pepper seeds differently. Tomato was most negatively affected, with reduced root length and width. Alfalfa showed mixed effects, with positive impacts on some parameters but negatives on others. Pepper seeds responded positively overall, with improved germination and root length, despite some impacts on root morphology.
Política de saúde e Autoridades Reguladoras: desafios da regulação de tecnologias nas Emergências em Saúde Pública
Authors: Oliveira Catia Veronica dos Santos , Pepe Vera Lúcia Edais
Published: July 2024

Resumo As Emergências em Saúde Pública (ESP) têm repercutido nos sistemas de saúde em escala global. O acesso às novas tecnologias em saúde em tempo oportuno é um desafio para a política de saúde. As autoridades reguladoras nacionais (ARN) têm papel fundamental na avaliação e regulação dessas tecnologias. O estudo objetiva analisar as principais estratégias e instrumentos regulatórios utilizados para lidar com os desafios da regulação de novas tecnologias necessárias à resposta do sistema de saúde durante as ESP. Trata-se de uma pesquisa normativa e documental, tendo como fonte a OMS e a ARN brasileira. Foram consideradas as dimensões relacionadas às estratégias para o fortalecimento das atividades regulatórias e os instrumentos regulatórios utilizados para acelerar o acesso às tecnologias, especialmente durante as ESP. A cooperação e a colaboração internacional entre as ARN e com a OMS foram importantes estratégias para o fortalecimento das ARN, com destaque para o uso de confiança, regionalização, avaliações aceleradas e compartilhamento de trabalho/informações, bem como os processos de harmonização e convergência regulatória. Identificou-se, além da utilização de instrumentos regulatórios já existentes, esforços na implementação de novos, com destaque para Autorização de Uso Emergencial.
Health policy and regulatory authorities: challenges of technology regulation in Public Health Emergencies
Authors: Oliveira Catia Veronica dos Santos , Pepe Vera Lúcia Edais
Published: July 2024

Abstract Public Health Emergencies (PHE) have had repercussions on health systems on a global scale, and timely access to new health technologies is a challenge for health policy. The national regulatory authorities (NRA) play a key role in the evaluation and regulation of these technologies. The present study aims to analyze the main strategies and regulatory instruments used to deal with the challenges of regulating new technologies necessary for the health system’s effective response during a PHE. This research, based on WHO and Brazilian NRA norms and documents, considered dimensions related to strategies for strengthening regulatory activities and regulatory instruments used to accelerate access to technologies, especially during PHEs. International cooperation between the NRA and the WHO were important strategies for strengthening the NRA, with emphasis on the use of reliance, regionalization, accelerated assessments, and work/information sharing, as well as the processes of regulatory harmonization and convergence. In addition to the use of existing regulatory instruments, efforts were also identified in order to implement new ones.
A comparison between the titanium-based and the zinc phosphate dispersion conditionings of zinc phosphate baths
Authors: Ramos Rosane Marchiori , Kunst Sandra Raquel , Soares Luana Góes , Schneider Eduardo Luís , Oliveira Cláudia Trindade
Published: July 2024

ABSTRACT Phosphating is a metallic surface treatment widely used in the industrial environment as it provides greater adhesion of the paint film to the metallic substrate and greater efficiency in inhibiting corrosion. The conditioning agents in the phosphating process contribute to reducing the time to obtain the phosphate layer and favor the refinement of the formed crystals. Commercially, the most used conditioning agent is based on titanium salts, however, it is possible that other compounds may be an alternative in optimizing the industrial process. Therefore, with the aim of reducing the time and temperature of the phosphating process, this work aims to verify the performance of using the conditioning agent based on zinc phosphate in obtaining the phosphatized layer, in terms of corrosion resistance, in comparison with to the titanium-based conditioner. For this purpose, SAE 1010 carbon steel samples were degreased and sandblasted, immersed for 1 minute in the conditioning solution (titanium or zinc phosphate) and phosphated with a commercial solution of tricationic zinc phosphate at different temperatures (40 and 50°C) and immersion times (2, 3 and 4 minutes). The deposited masses of the phosphate coatings were measured and the coatings characterized by scanning electron microscopy (SEM), through electrochemical tests of open circuit potential and potentiodynamic polarization. The results showed that the greater coverage of the substrate, with the formation of denser layers, improves the anticorrosive performance of samples phosphated with both conditioners. For the titanium-based conditioner, the optimal phosphating conditions were 3 min at 50°C, while for the zinc phosphate conditioner, they were 2 min at 40°C. Therefore, for commercial use, immersion in a zinc phosphate-based conditioner is indicated, followed by phosphating for 2 min at 40°C.
“Uma menina baiana, que sabe amar sua pátria”: imprensa e gênero na época da Independência do Brasil
Authors: Borges Eduardo
Published: July 2024

RESUMO Entre 1820 e 1823, o Brasil vivenciou o que tradicionalmente ficou conhecido como processo da independência. Em meio às disputas políticas, a imprensa teve uma participação ativa como tribuna pública, representando as ideias de seus editores e do segmento ideológico por eles representado. Este artigo analisa o discurso político presente nas páginas do jornal O Brasileiros em Coimbra, editado em Portugal pelo baiano Candido Japiassú. Para tanto, usamos como referência o conteúdo de uma carta publicada no jornal por uma baiana anônima identificada somente como “F”. A própria dinâmica do universo feminino da família Figueiredo e Melo, e a subjetividade do olhar de “F” sobre a guerra de independência na Bahia, podem ser analisadas com base no diálogo das diferentes escalas de análise entre o micro e o macro, em direta sintonia com a proposta metodológica da micro-história.
Writing and rewriting fictional narratives guided by Gianni Rodari’s creative proposals
Authors: Dalla-Bona Elisa Maria , Stapassoli Danielle Mari
Published: July 2024

Abstract Gianni Rodari (1982) presents consistent and entertaining alternatives for classroom textual production. Accordingly, an error is not a mistake to be corrected but a creative possibility of writing and rewriting. The objective of this action-research was to analyze the results of applying Rodarian proposals to the process of writing and rewriting fictional stories of 5th-grade students at a private school in Curitiba, Brazil. We conclude that the proposals efficiently formed literary readers and writers in elementary school.
Memórias de professoras e o uso de cartas como ferramenta pedagógica
Authors: Barbosa-Rinaldi Ieda Parra , Bisconsini Camila Rinaldi , Pires Ademir Faria , Vinholes Lara , Pizani Juliana
Published: July 2024

Resumo Esta resenha visa discutir e apresentar a obra intitulada Memórias da educação física na escola: cartas de professoras, de Eliana Ayoub. O objetivo apresentado é promover reflexões a respeito da educação física (EF), do corpo e da gestualidade na escola, a partir das narrativas de alunas-professoras participantes do Programa Especial de Formação de Professores em Exercício na Rede Municipal dos Municípios da Região Metropolitana de Campinas. Fruto da tese de livre docência da autora, as cartas que compõem o livro relacionam processos formativos em que Ayoub vivenciou ao longo de suas experiências como professora, pesquisadora e como aluna no universo da EF, entretecidos com suas experiências de vida e dos sujeitos presentes nessa trajetória.
Participation of the Permanent Secretariat of Forum Macao in Global Health initiatives between 2015 and 2022
Authors: Verly-Miguel Marcus
Published: July 2024

Abstract The Forum for Economic and Trade Cooperation between China and Portuguese-speaking Countries, better known as Forum Macao, founded in 2003, has been acting as a link between China and Portuguese-speaking countries for 20 years. Since 2016, the Permanent Secretariat of Forum Macao has published a yearbook highlighting the main activities it carried out in the previous year. This article focuses on analyzing Forum Macao's role as an organizer and mediator of Global Health initiatives by analyzing all the articles published in its yearbooks between 2016 and 2023. We found 34 articles dealing with a health-related topic, with almost two thirds related to traditional Chinese medicine, reports of frequent organization of activities that foster international cooperation in health, as well as active participation during the first year of the Covid-19 pandemic. Forum Macao is a multilateral platform for dialogue between China, Macao and the Portuguese-speaking world, with the health agenda and the dissemination of traditional Chinese medicine occupying a prominent place in its yearbook.