bluuebunny/crossref_metadata_2025 huggingface dataset:
A Feminist Theology of Testimony
Authors: Kidd Erin
Published: September 2022

Feminist activists and women’s studies scholars have referred to moments where women understand the impact of sexism on their lives as clicks. Karl Rahner’s account of witness will help us identify why such clicks are theological. In turn, analysis of these clicks in conversation with feminist epistemology will illuminate what it will require to become hearers of the Word. A feminist theology of testimony calls us to facilitate theological inclusion and the development of theological subjects.
How sanitary pads came to save the world: Knowing inclusive innovation through science and the marketplace
Authors: Parthasarathy Shobita
Published: September 2022

International development institutions, governments, and social entrepreneurs have become increasingly enthusiastic about ‘inclusive innovation’ which, to solve problems in low- and middle-income countries, focuses on the development of technologies for and by the poor. Inclusive innovation differs from previous development efforts by focusing on devices instead of infrastructure, claiming to be based on scientific evidence, and relying on market logics to achieve humanitarian ends. Proponents argue that, informed by grassroots efforts, these interventions have enormous potential to catalyze economic, social, and political change. How are the market and technological imperatives of inclusive innovation shaping the international development agenda? What do inclusion and innovation mean in this context? What can inclusive innovation tell us about the proliferation of initiatives that promote technology for public good, from responsible innovation to public interest technology? This article examines these questions through a case study of menstrual hygiene management (MHM) innovation in India. Rather than providing solutions to self-evident development problems, inclusive innovation shapes both development problems and solutions simultaneously, in areas where scientific and market ways of knowing converge. These ways of knowing claim to be legitimate because they are rooted in local knowledge and expertise. MHM in India became a problem, and low-cost disposable sanitary pads an inclusive innovative solution, because of the involvement of Indian researchers and innovators, and Indian girls and women as consumers and producers. However, in the process they reinforced narrow understandings of both inclusion and innovation in international development. Inclusion efforts may be wrapped up in political economies that shape and limit their transformational power by prioritizing scientific, technical, and market expertise.
Preparedness of Residents and Medical Students for the Transition to Competence by Design in Diagnostic Radiology Post-Graduate Medical Education
Authors: Bentley Helena , Lee Juvel , Supersad Alanna , Yu Hang , Dobson Jessica L. , Wong Scott A. , Stewart Matthew , Vatturi Sri Sannihita , Lebel Kiana , Crivellaro Priscila , Khatchikian Aline D. , Hague Cameron J. , Taylor Jana , Probyn Linda
Published: September 2022

Introduction: This needs assessment evaluated residents’ and medical students’ knowledge of Competence by Design (CBD), perceived benefits of and challenges or barriers to the transition to CBD for residents, and perceived overall preparedness for the transition to CBD in diagnostic radiology. Materials and Methods: All diagnostic radiology residents and medical students in Canada were eligible to participate in this national cross-sectional, questionnaire-based needs assessment. Knowledge of CBD was evaluated through participants’ self-reported rating of their knowledge of CBD on a 5-point Likert scale. Perceived benefits of and challenges or barriers to the transition to CBD for residents were rank ordered. Participants’ overall self-reported preparedness for the transition to CBD was assessed on a 5-point Likert scale. Data were summarized by descriptive statistics and bivariate analyses were conducted as appropriate. Results: Ninety-four residents ( n = 77) and medical students ( n = 17) participated in this needs assessment. Participants’ mean ± standard deviation self-reported rating of their overall knowledge of CBD was 2.86 ± .94. Provision of meaningful feedback to learners and learners’ ability to identify their own educational needs were among the highest ranked perceived benefits of the transition to CBD, while demands on time and increased frequency of evaluation were among the highest ranked perceived challenges or barriers to the transition to CBD. Few participants reported being either “prepared” (4.7%) or “somewhat prepared” (14.0%) for the transition to CBD. Conclusion: Preparedness for the transition to CBD in diagnostic radiology may be improved. Targeted interventions to augment the preparedness of residents and medical students should be considered.
Customer Perception Towards Pradhan Mantri Jan-Dhan Yojana (PMJDY): An Empirical Investigation from Slum-dwellers Perspective
Authors: Ray Koustubh Kanti
Published: September 2022

The government-sponsored welfare programmes are instrumental in balancing economic growth and reducing inequalities in society. Society becomes inclusive only when the deprived people have access to banking and financial services. The policymakers and financial players emphasized the importance of financial inclusion programmes because of their significant impact on economic growth and the financial health of the economy. The Pradhan Mantri Jan-Dhan Yojana (PMJDY) is a government-led intervention programme with a national mission to provide banking facilities to all deprived sections in the country. The study focuses to examine the determinants of customer perception towards PMJDY. The study includes the slum dwellers of Bhubaneswar as the target group of beneficiaries for empirical research. The determinants include the delivery process (SERVQUAL) and outcome attributes associated with the social scheme. As customer perception is a categorical variable, the multinomial logistic regression model is adopted to test the hypothesis. The study results indicate that the beneficiaries consider reliability, assurance, tangibility and social connect dimensions as the likely factors to obtain a higher level of perception towards the welfare programme.
Does Value Similarity Matter? Influence of Ethical Leadership on Employee Engagement and Deviance
Authors: Houston Lawrence , Ferris D. Lance , Crossley Craig
Published: September 2022

Although ethical leadership is thought to motivate employees to refrain from deviant behaviors that are harmful to the organization and its members, scholars have also found considerable variability in the relationship between ethical leadership and deviant subordinate behaviors beyond this general or main effect. Integrating theory on ethical leadership and work engagement, we develop and test a model that also considers the role of employee-leader value similarity in understanding employee interpersonal and organizational deviance. In two field studies employing multi-wave samples of leader-subordinate dyads, we demonstrate that value similarity moderates the effects of ethical leadership on subordinate deviance and does so via engagement. Implications for ethical leadership, employee engagement, and deviance literature are discussed.
Domestic Violence Against Women in the Workplace: Difficulties at the Personal and Professional Levels
Authors: Al-Modallal Hanan
Published: September 2022

Effect of domestic violence (including employment interference/restraint) on women’s personal and professional difficulties and whether employment interference/restraint is affected by familial and demographic characteristics were examined. Data from 177 workplace-participating women in a higher educational institution was used. Linear regression analysis was used to examine the associations. It was revealed that working women suffered from a wide range of difficulties at the personal and professional levels. However, personal difficulties were more prevalent compared to professional difficulties. Among participants’ familial and demographic characteristics, only “number of children” was significant in predicting exposure to employment interference/restraint. Tactics of employment interference/restraint are characterized by being “controlling” in nature. This characteristic explained women’s reports of violence and complaints from related difficulties. Personal difficulties associated with employment interference/restraint were representative, and similar, to mental health problems. It is recommended that primary prevention interventions are emphasized taking into consideration the role of women, coworkers, as well as employers in terminating this problem.
Measuring Deltoid Insufficiency After Supination-External Rotation Ankle Fracture With Lateral Talar Subluxation on Gravity Stress View
Authors: Haupt Edward T. , Sebro Ronnie , Iturregui Jose M. , Stanborough Rupert , Siddiqui Ali , Shi Glenn G.
Published: September 2022

Background:

Stress-view radiographs are frequently obtained to evaluate supination-external rotation (SER) variant ankle fractures. Measurement of the ankle medial clear space (MCS) is a surrogate of medial structure integrity as part of overall ankle stability. Measurement of the lateral talus displacement with respect to the incisura may be a sensitive and specific method to assess joint subluxation.

Methods:

Retrospective review of acute SER-variant isolated lateral malleolar fractures with gravity stress views (GSVs) were performed for 103 patients. GSV analysis was performed with standardized measurements of the MCS, superior clear space (SCS), and 2 new novel measurements of lateral talus subluxation (LTS). Decision for surgery was obtained by surgeons who reviewed masked injury radiographs for predictive performance analysis of the LTS vs MCS.

Results:

MCS, SCS, and LTS measurements were performed on 103 patients. Mean MCS, SCS, and LTS within the operative group was increased. MCS ≥5 mm and LTS >4 mm had equal sensitivity (95%), with higher specificity for LTS (75% vs 60%). Receiver operating characteristic analysis demonstrates an area under the curve of 0.786 for MCS ≥5 mm vs 0.918 for LTS >4 mm.

Conclusion:

We found LTS to be superior to MCS for medial ankle structure stability on gravity stress views of SER-variant ankle fractures. We propose this as a useful tool for clinicians to consider when evaluating SER-variant ankle fractures.

Level of Evidence:

Level II, prospective comparative study of radiographs.
The promised capitals of international high school programmes and the global field of higher education: The case of Shenzhen, China
Authors: Wright Ewan , Mulvey Benjamin
Published: September 2022

The term ‘international school’ encompasses a broad array of institutions offering a range of different programmes. However, the differences between these programmes have scarcely been explored in the existing literature. This article focuses on three popular international high school programmes (Advanced Levels, Advanced Placement, and International Baccalaureate Diploma Programme) by drawing upon in-depth interviews with international school counsellors, teachers, parents, and students in Shenzhen, China. We employed the Bourdieusian concepts of ‘promised capitals’ and the ‘global field of higher education’ to delineate differences amongst these international programmes. We argue that each international programme promises the accumulation of distinct combinations of capitals associated with different global circuits of mobility for higher education. At the same time, we also suggest that the extent to which the promised capitals are conferred is complicated by the ‘localisation’ of schools: this impacted the delivery of promises related to embodied cultural and social capital forms.
Boxing as an Intervention in Mental Health: A Scoping Review
Authors: Bozdarov Johny , Jones Brett D. M. , Daskalakis Zafiris J. , Husain M. Ishrat
Published: September 2022

Introduction: Physical activity has been shown to have a multitude of mental health benefits. However, there is limited evidence on the specific mental health benefits of boxing. We conducted a scoping review of academic and grey literature to map research of boxing exercises as an intervention in mental health and to identify gaps in knowledge. Methods: The authors utilized the PRISMA-ScR methodological approach and guidelines from the Joanna Briggs Institute and a structured search was completed from inception until August 08, 2022. Results: We identified 16 documents that used non-contact boxing as an exercise intervention that improved various mental health difficulties. Non-contact boxing exercises, usually in a high-intensity-interval training group setting, provided significant reduction in symptoms of anxiety, depression, PTSD and negative symptoms of schizophrenia. Non-contact boxing provided a cathartic release of anger and stress, with evidence of improved mood, self-esteem, confidence, concentration, metabolic burden, strength and coordination. Conclusions: Preliminary evidence indicates that non-contact boxing exercises are a promising intervention to improve mental health burden. Further well designed randomized controlled trials using group, non-contact boxing exercises as an intervention for common mental disorders are warranted to confirm its benefits for mental health.
Tell me all about it: Narrated memories are less emotional than imagined memories
Authors: Andrade Jackie , IJdema Tom , Vadasz Nicola , May Jon
Published: September 2022

People often re-live memories by talking about them. Verbal thinking is usually less emotive than imagery-based thinking but it is not known if this finding generalises to recollection. We tested if narrating memories aloud reduces their affective charge compared with recollecting them using imagery. Participants were randomised to two conditions: imagery (recalling the memory silently as vividly as possible) or narration (describing the memory out loud as clearly as possible). After practicing with a neutral topic, they recalled three aversive (Experiments 1 and 2) or three happy (Experiment 3) memories using narration or imagery, and rated emotionality of the memory after each recall. Before and after the procedure, they completed the PANAS to measure effects on mood. Experiments 2 and 3 included a 24 h follow-up. Emotionality was consistently lower following narrated recollection than imaginal recollection: narrated M = 5.3, SD = 2.5; imaginal M = 7.2, SD = 2.0; effect size (difference in mean values divided by overall SD) = 0.78. Negative affect increased after recollection of aversive memories and positive affect decreased, but there were no effects of condition upon mood. Recalling a positive memory had no effect on mood. Follow-up data showed no lasting effects of recall mode on availability of memories or mood. We conclude that narration of emotional autobiographical memories reduces the emotionality of the recollection, but does not differentially change mood compared with image-based recall.
Internet involvement, information consumption, and political participation in urban China
Authors: Wang Xinxi , Meng Tianguang
Published: September 2022

The issue of whether the internet promotes political participation has always been a hotly debated topic in academia. However, current research lacks an effective classification of the modes of internet use, and it does not analyze their effect on different forms of political participation. Based on data from the 2015 and 2018 waves of the China Urban Governance Survey, this study offers an examination of the internet usage behavior of Chinese urban netizens from the perspectives of internet involvement and information consumption, as well as comparing the impact that different modes of internet use have on conventional and unconventional political participation. The results of this study confirm the “citizen-empowerment hypothesis” of internet use, and show that the “group involvement–social-information-oriented” mode of internet use has a positive effect on the conventional and unconventional political participation of urban internet users. However, the study fails to support the “time-displacement hypothesis”. It shows that the “individual involvement–entertainment-oriented” mode of internet use does not have a negative impact on the conventional and unconventional political participation of Chinese urban internet users. Similarly, the “group involvement–entertainment-oriented” mode of internet use has no significant effect on unconventional political participation. Taken together, the study shows that, in general, internet use has promoted the political participation of Chinese urban netizens, but there are significant differences between the different modes of internet use. As a revolutionary medium, the internet not only provides people with a convenient way of obtaining and communicating information, but also creates more challenges for state governance. The way in which the government should deal with different forms of political participation in the internet age will be an important research topic in the future.
Serum CGRP in migraine patients using erenumab as preventive treatment
Authors: de Vries Lentsch Simone , Garrelds Ingrid M. , Danser A. H. Jan , Terwindt Gisela M. , MaassenVanDenBrink Antoinette
Published: September 2022

Aim

Serum levels of Calcitonin Gene-Related Peptide (CGRP)-like immunoreactivity (CGRP-LI) in migraine patients before and after starting treatment with erenumab were measured to evaluate the association with clinical treatment response.

Methods

Blood samples were collected from the cubital fossa before (T0) and 2–4 weeks after (T1) starting treatment with erenumab. Clinical response was monitored using a daily headache e-diary. Serum levels of CGRP-LI, assessed using radioimmunoassay, were compared between T0 and T1, correcting for migraine reduction. In addition, for both T0 and T1, linear regression models were constructed using migraine reduction as outcome and serum CGRP-LI as independent variable, corrected for age, gender and monthly migraine days (MMD) at baseline.

Results

Serum CGRP-LI did not differ between T0 and T1 (p = 0.30). However, there was an interaction between time and reduction in MMD (p = 0.01). Absolute reduction in MMD in the third month after treatment with erenumab was associated with serum CGRP-LI at T1, 2–4 weeks after starting treatment with erenumab (p = 0.003), but not with serum CGRP-LI at T0 (p = 0.24).

Conclusion

Lower serum CGRP-LI 2–4 weeks after starting treatment with erenumab was associated with a higher reduction in migraine days after three months of treatment. Although the underlying mechanisms remain to be determined, this suggests that changes in CGRP levels, shortly after starting erenumab, are important for its clinical effect.
Artificial Intelligence-Aided Low Cost and Flexible Graphene Oxide-Based Paper Sensor for Ultraviolet and Sunlight Monitoring
Authors: Abusultan Ahmed , Abunahla Heba , Halawani Yasmin , Mohammad Baker , Alamoodi Nahla , Alazzam Anas
Published: September 2022

The adverse effect of ultraviolet (UV) radiation on human beings has sparked intense interest in the development of new sensors to effectively monitor UV and solar exposure. This paper describes a novel low-cost and flexible graphene oxide (GO)-based paper sensor capable of detecting the total amount of UV or sun energy delivered per unit area. GO is incorporated into the structure of standard printing paper, cellulose, via a low-cost fabrication technique. The effect of UV and solar radiation exposure on the GO paper-based sensor is investigated using a simple color change analysis. As a result, users can easily determine the amount of ultraviolet or solar energy received by the sensor using a simple color analysis application. A neural network (ANN) model is also explored to learn the relation between UV color intensity and exposure time, then digitally display the results. The accuracy for the developed ANN reached 96.83%. The disposable, cost-effective, simple, biodegradable, safe, and flexible characteristics of the paper-based UV sensor make it an attractive candidate for a variety of sensing applications. This work provides new vision toward developing highly efficient and fully disposable GO-based photosensors.

Graphical Abstract
Fossil soils: trace fossils of ecosystems on land and windows on the context of evolution
Authors: Leigh Egbert Giles
Published: September 2022

This is a review of Soil Grown Tall: The Epic Saga of Life from Earth, by Gregory J. Retallack. In this book, Retallack shows how soils and life have coevolved over the last 3.5 billion years, and what soils tell us about the environments in which various terrestrial organisms have evolved and flourished. A theme of the book is the Proserpina Principle: producers consume CO2, consumers exhale it, and alternating dominance of producers and consumers alternates global warming and cooling, while keeping temperature within life-permitting limits.
Comparison of the novel WEst coast System for Triage (WEST) with Rapid Emergency Triage and Treatment System (RETTS©): an observational pilot study
Authors: Habbouche Samah , Carlson Tobias , Johansson Daniel , Kjaerbeck Schani , Malm Mathias , Svensson Per-Arne , Holmqvist Lina
Published: September 2022

Background

Most Swedish emergency departments (ED) use the triage system Rapid Emergency Triage and Treatment System (RETTS©), which over time has proven to prioritize patients to higher triage levels. When many patients are prioritized to high triage levels, challenges with identifying true high-risk patients and increased waiting time for these patients has emerged. In order to achieve a more balanced triage in relation to actual medical risk, the triage system WEst coast System for Triage (WEST) was developed, based on the South African Triage Scale (SATS). The aim of this study was to perform an initial evaluation of the novel emergency triage system WEST compared to the existing RETTS©.

Methods

Both RETTS© and WEST are five level triage systems illustrated by colors. Nurses from each of the three adult EDs of Sahlgrenska University Hospital in Gothenburg and the ambulance service assessed and triaged 1510 patients according to RETTS© and immediately thereafter filled out the WEST triage form. Data from each triage report were analyzed and grouped according to the triage color, chief complaint, and outcome of each patient. Data on discharge categories and events within 72 h were also collected. Data were analyzed with descriptive statistical methods.

Results

In general, WEST displayed lower levels of prioritization compared to RETTS©, with no observed impact on patients’ medical outcomes. In RETTS© orange triage level, approximately 50% of the patients were down prioritized in WEST to yellow or green triage levels. Also, in the RETTS© yellow triage level, more than 55% were down prioritized to green triage level in WEST. The number of patients who experienced a serious event during the first 72 h was few. Three patients died, these were all prioritized to red triage level in RETTS©. In WEST two of these patients were prioritized to red triage level and one to orange triage level. All these patients were admitted to hospital before deterioration.

Conclusions

WEST may reduce over prioritization at the ED, especially in the orange and yellow triage levels of RETTS©, with no observed increase in medical risk. WEST can be recommended for a clinical comparative study.
Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)
Authors: Jaiswal Swati , Nyquist Sarah K. , Boyce Shayla , Jivanjee Tasneem , Ibrahim Samira , Bromley Joshua D. , Gatter G. James , Gideon Hannah , Patel Kush , Ganchua Sharie Keanne , Berger Bonnie , Fortune Sarah M. , Flynn JoAnne L. , Shalek Alex K. , Behar Samuel M.
Published: September 2022

Background

Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research. Cynomolgus macaques share behavioral, physiological, and genomic traits with humans and recapitulate human disease manifestations not observed in other animal species. To improve the use of the cynomolgus macaque model to investigate immune responses, we defined and characterized the T cell receptor (TCR) repertoire.

Result

We identified and analyzed the alpha (TRA), beta (TRB), gamma (TRG), and delta (TRD) TCR loci of the cynomolgus macaque. The expressed repertoire was determined using 22 unique lung samples from Mycobacterium tuberculosis infected cynomolgus macaques by single cell RNA sequencing. Expressed TCR alpha (TRAV) and beta (TRBV) variable region genes were enriched and identified using gene specific primers, which allowed their functional status to be determined. Analysis of the primers used for cynomolgus macaque TCR variable region gene enrichment showed they could also be used to amplify rhesus macaque (M. mulatta) variable region genes.

Conclusion

The genomic organization of the cynomolgus macaque has great similarity with the rhesus macaque and they shared > 90% sequence similarity with the human TCR repertoire. The identification of the TCR repertoire facilitates analysis of T cell immunity in cynomolgus macaques.
Variation in morpho-physiological and metabolic responses to low nitrogen stress across the sorghum association panel
Authors: Grzybowski Marcin W. , Zwiener Mackenzie , Jin Hongyu , Wijewardane Nuwan K. , Atefi Abbas , Naldrett Michael J. , Alvarez Sophie , Ge Yufeng , Schnable James C.
Published: September 2022

Background

Access to biologically available nitrogen is a key constraint on plant growth in both natural and agricultural settings. Variation in tolerance to nitrogen deficit stress and productivity in nitrogen limited conditions exists both within and between plant species. However, our understanding of changes in different phenotypes under long term low nitrogen stress and their impact on important agronomic traits, such as yield, is still limited.

Results

Here we quantified variation in the metabolic, physiological, and morphological responses of a sorghum association panel assembled to represent global genetic diversity to long term, nitrogen deficit stress and the relationship of these responses to grain yield under both conditions. Grain yield exhibits substantial genotype by environment interaction while many other morphological and physiological traits exhibited consistent responses to nitrogen stress across the population. Large scale nontargeted metabolic profiling for a subset of lines in both conditions identified a range of metabolic responses to long term nitrogen deficit stress. Several metabolites were associated with yield under high and low nitrogen conditions.

Conclusion

Our results highlight that grain yield in sorghum, unlike many morpho-physiological traits, exhibits substantial variability of genotype specific responses to long term low severity nitrogen deficit stress. Metabolic response to long term nitrogen stress shown higher proportion of variability explained by genotype specific responses than did morpho-pysiological traits and several metabolites were correlated with yield. This suggest, that it might be possible to build predictive models using metabolite abundance to estimate which sorghum genotypes will exhibit greater or lesser decreases in yield in response to nitrogen deficit, however further research needs to be done to evaluate such model.
Survival after traumatic cardiac arrest is possible—a comparison of German patient-registries
Authors: Seewald Stephan , Wnent Jan , Gräsner Jan-Thorsten , Tjelmeland Ingvild , Fischer Matthias , Bohn Andreas , Bouillon Bertil , Maurer Holger , Lefering Rolf
Published: September 2022

Background

Out-of-hospital cardiac arrest (OHCA) due to trauma is rare, and survival in this group is infrequent. Over the last decades, several new procedures have been implemented to increase survival, and a “Special circumstances chapter” was included in the European Resuscitation Council (ERC) guidelines in 2015. This article analysed outcomes after traumatic cardiac arrest in Germany using data from the German Resuscitation Registry (GRR) and the TraumaRegister DGU® (TR-DGU) of the German Trauma Society. 

Methods

In this study, data from patients with OHCA between 01.01.2014 and 31.12.2019 secondary to major trauma and where cardiopulmonary resuscitation (CPR) was started were eligible for inclusion. Endpoints were return of spontaneous circulation (ROSC), hospital admission with ROSC and survival to hospital discharge.

Results

1.049 patients were eligible for inclusion. ROSC was achieved in 28.7% of the patients, 240 patients (22.9%) were admitted to hospital with ROSC and 147 (14.0%) with ongoing CPR. 643 (67.8%) patients were declared dead on scene. Of all patients resuscitated after traumatic OHCA, 27.3% (259) died in hospital. The overall mortality was 95.0% and 5.0% survived to hospital discharge (47). In a multivariate logistic regression analysis; age, sex, injury severity score (ISS), head injury, found in cardiac arrest, shock on admission, blood transfusion, CPR in emergency room (ER), emergency surgery and initial electrocardiogram (ECG), were independent predictors of mortality.

Conclusion

Traumatic cardiac arrest was an infrequent event with low overall survival. The mortality has remained unchanged over the last decades in Germany. Additional efforts are necessary to identify reversible cardiac arrest causes and provide targeted trauma resuscitation on scene.

Trial registration

DRKS, DRKS-ID DRKS00027944. Retrospectively registered 03/02/2022.
Association between environmental exposure to perchlorate, nitrate, and thiocyanate and serum α-Klotho levels among adults from the National Health and nutrition examination survey (2007–2014)
Authors: Yao Yu , He Gao-yan , Wu Xiao-juan , Wang Chao-ping , Luo Xiao-bin , Zhao Yong , Long Ying
Published: September 2022

Background & aims

Aging is a pathophysiological process driven by a diverse set of complex biological processes, and environmental pollution plays an important role in this process. This study aimed to explore the association between serum α-Klotho levels and urinary perchlorate, nitrate, and thiocyanate levels.

Methods

This secondary dataset analysis included 4875 participants (mean age, 57.69 year; male, 49.58%; non-Hispanic White, 47.67%) from the US National Health and Nutrition Examination Survey (2007–2014). Enzyme-linked immunosorbent assay was used to quantify α-Klotho levels, and ion chromatography coupled with electrospray tandem mass spectrometry was used to quantify thiocyanate, nitrate, and perchlorate levels. Multivariate linear regression models were applied to estimate the association between perchlorate, nitrate, and thiocyanate levels and serum α-Klotho levels.

Results

Urinary thiocyanate levels were negatively associated with α-Klotho levels (β = − 0.006; 95% confidence interval, − 0.010 to − 0.003; P = 0.0004) after adjusting for age, sex, body mass index, race, alcohol consumption, estimated glomerular filtration rate, underlying disease, physical activity, smoking status, usual energy intake, and urinary creatinine and serum cotinine levels and mutual adjustment of urinary perchlorate, urinary nitrate, and urinary thiocyanate levels. The α-Klotho level in participants in the highest quartile was higher by 50.567 ng/mL (β = 50.567; 95% confidence interval, 14.407 to 86.726; P = 0.009) than that in participants in the lowest quartile of urinary perchlorate. A linear relationship was observed between urinary thiocyanate and α-Klotho levels.

Conclusions

Urinary thiocyanate levels were negatively associated with serum α-Klotho levels. Urinary thiocyanate should be further investigated as a potential mediator of aging and age-related diseases.
Construction of machine learning tools to predict threatened miscarriage in the first trimester based on AEA, progesterone and β-hCG in China: a multicentre, observational, case-control study
Authors: Huang Jingying , Lv Ping , Lian Yunzhi , Zhang Meihua , Ge Xin , Li Shuheng , Pan Yingxia , Zhao Jiangman , Xu Yue , Tang Hui , Li Nan , Zhang Zhishan
Published: September 2022

Background

Endocannabinoid anandamide (AEA), progesterone (P4) and β-human chorionic gonadotrophin (β-hCG) are associated with the threatened miscarriage in the early stage. However, no study has investigated whether combing these three hormones could predict threatened miscarriage. Thus, we aim to establish machine learning models utilizing these three hormones to predict threatened miscarriage risk.

Methods

This is a multicentre, observational, case-control study involving 215 pregnant women. We recruited 119 normal pregnant women and 96 threatened miscarriage pregnant women including 58 women with ongoing pregnancy and 38 women with inevitable miscarriage. P4 and β-hCG levels were detected by chemiluminescence immunoassay assay. The level of AEA was tested by ultra-high-performance liquid chromatography-tandem mass spectrometry. Six predictive machine learning models were established and evaluated by the confusion matrix, area under the receiver operating characteristic (ROC) curve (AUC), accuracy and precision.

Results

The median concentration of AEA was significantly lower in the healthy pregnant women group than that in the threatened miscarriage group, while the median concentration of P4 was significantly higher in the normal pregnancy group than that in the threatened miscarriage group. Only the median level of P4 was significantly lower in the inevitable miscarriage group than that in the ongoing pregnancy group. Moreover, AEA is strongly positively correlated with threatened miscarriage, while P4 is negatively correlated with both threatened miscarriage and inevitable miscarriage. Interestingly, AEA and P4 are negatively correlated with each other. Among six models, logistic regression (LR), support vector machine (SVM) and multilayer perceptron (MLP) models obtained the AUC values of 0.75, 0.70 and 0.70, respectively; and their accuracy and precision were all above 0.60. Among these three models, the LR model showed the highest accuracy (0.65) and precision (0.70) to predict threatened miscarriage.

Conclusions

The LR model showed the highest overall predictive power, thus machine learning combined with the level of AEA, P4 and β-hCG might be a new approach to predict the threatened miscarriage risk in the near feature.
Decision-making about gene therapy in transfusion dependent thalassemia
Authors: Quarmyne Maa-Ohui , Ross Diana , Sinha Cynthia , Bakshi Nitya , Boudreaux Jeanne , Krishnamurti Lakshmanan
Published: September 2022

Background

Hematopoietic stem cell transplantation (HSCT) is a treatment option with curative intent for patients with transfusion dependent thalassemia (TDT) but its application is limited by the lack of suitable donors and acceptability due to the related morbidity/mortality. Transplantation of autologous genetically modified hematopoietic cells, gene therapy (GT) is emerging as a promising treatment option for TDT as it eliminates graft versus host disease (GVHD) and need for immunosuppression. Early results of GT suggest that many, but not all patients achieve transfusion independence after the procedure. There is little information about the acceptability of GT in patients with TDT. We sought to examine patient/family knowledge about GT in TDT and to examine factors that influence decision-making about this therapy.

Methods

Parents of children with TDT and adults with TDT were who provided informed consent underwent semi-structured interviews to understand patient/family knowledge and decision-making regarding GT in TDT. Transcribed interviews were coded and the data was examined for emerging themes using a combination of thematic and content analysis.

Results

Twenty-five study participants with mean age of 38Y (17—52Y) including eight adults living with TDT, and 17 parents of children with TDT underwent semi-structured qualitative interviews. Participant responses coalesced around broad themes related to knowledge of GT, motivating/deterring factors and outcomes. Study participants expressed a desire for ‘cure’ from thalassemia including transfusion independence, chelation reduction and improved quality of life as motivators for considering GT. Insufficient knowledge about the process, long-term outcomes, safety, and side effects as well as the potential for death/failure of the procedure were deterrents for the consideration GT. Reduction in frequency of transfusions, even without elimination of transfusions was an acceptable outcome of GT for most participants. Participant choice for preferred treatment modality was split between indefinitely continuing transfusions which was familiar to them versus GT which was unfamiliar, and with an uncertain outcome. None of the participants had a matched sibling donor; alternate donor HSCT was the least preferred option in this group.

Conclusion

There is tempered excitement about GT in patients/families with TDT with a general willingness to accept transfusions reduction as the outcome.
Assessment of physical activity and its facilitators and barriers among Syrian refugees living in Amman City, Jordan: a cross-sectional study
Authors: Yoshino Yasue , Sato Miho , Abu-Siam Ibraheem , Khost Nadine , Honda Sumihisa , Qarawi Ahmad T. , Hassan Osama Gamal , Huy Nguyen Tien , Kamiya Yasuhiko
Published: September 2022

Background

Physical inactivity is one of the major risk factors for non-communicable diseases. Few studies about physical activity have been conducted among refugees from neighbouring countries. Given changes in the situation of Syrians, assessment of physical activity among Syrian refugees is required to understand their situation. This study aimed to evaluate the degree of self-reported physical activity and to identify perceived facilitators of and barriers to physical activity among Syrian refugees living in Amman, Jordan, in 2017.

Methods

This community-based cross-sectional study was conducted using a structured questionnaire and the short form of the International Physical Activity Questionnaire. Participants were eligible for the study if they were Syrian refugees aged 18–64 years, living in Amman city, and were either registered with the United Nations High Commissioner for Refugees, waiting for their registration, or had a service card issued by the Jordanian Ministry of Interior. The relationship between physical activity level and sex was assessed using the chi-square test and Cochran–Armitage tests. The Mann–Whitney U test was performed to assess the relationship between the median metabolic equivalent scores of physical activity and gender. Backward stepwise logistic regression analysis was used to analyse the association between predictors of physical inactivity and physical activity level.

Results

Among the 173 participants, the majority (91.9%) reported moderate to a high level of physical activity, and 8.1% were physically inactive. The metabolic equivalent scores for the walking activity of males (median: 1039.5, IQR: 0, 2772) was significantly higher than that of females (median: 396, IQR: 0, 1188) (p < 0.01). “Perceived change in the amount of physical activity” was a significant predictor of physical inactivity (adjusted OR = 3.00; 95%CI: 1.27–7.26). Common facilitators of physical activity were “psychological wellbeing”(49.7%) and “prevent diseases”(46.8%). The greatest barriers to physical activity were “time limitation”(43.4%) and “high cost”(57.8%).

Conclusion

This study revealed the physical activity level among Syrian refugees in Amman. The perceived facilitators and barriers to physical activity identified among Syrian refugees were similar to those in previous studies conducted among non-refugees. These results provide a valuable baseline for future examinations of physical activity level and to verify its possible facilitators and barriers.
Information System as part of epidemic management in Burkina Faso: from plan to reality (Field Findings)
Authors: Diallo Cheick Omar , Schiøler Karin Linda , Samuelsen Helle , Drabo Koine Maxime
Published: September 2022

Background

Health information systems (HIS) in most developing countries face many challenges. In view of the recurrent weaknesses in preparedness and response during the management of epidemics, we have examined the organization and functioning of the health information system in Burkina Faso.

Methods

We conducted a cross-sectional study from January 1, 2020 to March 31, 2020 including a review of HIS documents, key informant interviews and direct observations. The study was conducted at the public primary health care (PHC) and community level of Bama and Soumagou, in the rural health districts of Dandé and Tenkodogo. Study participants included community-based health workers (CBHWs) and health workers in the PHC areas, community-based organization animators (CBOAs), CBO monitoring-evaluation officers and members of the District management team (DMT).

Results

While reporting forms used in all health facilities are standardized, they are not necessarily well understood at community level and at the health centers. Reports prepared by CBHWs are often delayed by the head nurse at the primary health care service. Case definitions of epidemic diseases are not always well understood by community-based health workers and front-line health workers.

Conclusion

The health information system in Burkina Faso can be improved using simple strategies. There is a need to hold regular training/refresher sessions for agents involved in surveillance and to ensure the development of simplified case definitions for emerging diseases and/or diseases of public health interest for community use. Furthermore, existing epidemic management committees need to be revitalized.
Risk perceptions of drinking bottled vs. tap water in a low-income community on the US-Mexico Border
Authors: Victory Kerton R. , Wilson Amanda M. , Cabrera Nolan L. , Larson Daniela , Reynolds Kelly A. , Latura Joyce , Beamer Paloma I.
Published: September 2022

Background

Previous studies have shown that low-income Latinos generally drink bottled water over tap water and might be at increased risks for cavities from unfluoridated bottled water. In order to better design interventions, it is important to understand the risk perceptions of this unique high-risk yet historically marginalized group.

Methods

We interviewed low-income Latino households (n = 90) from Nogales, Arizona who primarily drink bottled water and asked them to evaluate potential health risks of drinking tap water compared to 16 other voluntary activities. Unpaired t-tests were used to determine if statistically significant (α = 0.05) differences occurred in perceived risk by drinking-water source and differences among demographic groups in their level of (dis)agreement with statements regarding tap or bottled water safety. To assess significant differences (α = 0.05) in perceived risks and voluntariness to engage in a number of activities, including drinking local tap water and drinking water in different geographic regions, a one-way analysis of variance (ANOVA) followed by Scheffe’s post-hoc test (a conservative post-hoc test) with adjustment for the number of pairwise comparisons was used.

Results

Participants viewed bottled water to be significantly safer to consume than tap water (p < 0.001). On a Likert scale from 1 (low risk) to 5 (high risk), “drinking tap water in Nogales, Arizona” received an average score of 4.7, which was significantly higher than the average perceived risk of drinking San Francisco, California tap water (µ = 3.4,p < 0.001), and as risky as drinking and driving (µ = 4.8,p = 1.00) and drinking Nogales, Sonora, Mexico tap water (µ = 4.8,p = 1.00). Ninety-eight percent of participants feared that drinking local tap water could result in illness, 79% did not drink their water because of fear of microbial and chemical contamination and 73% would drink their water if they knew it was safe regardless of taste.

Conclusions

These results suggest that fear of illness from tap-water consumption is an important contributing factor to increased bottled water use. Future efforts should focus on the development of educational and outreach efforts to assess the safety and risks associated with tap-water consumption.
MRI grading of spinal stenosis is not associated with the severity of low back pain in patients with lumbar spinal stenosis
Authors: Minetama Masakazu , Kawakami Mamoru , Teraguchi Masatoshi , Matsuo Sachika , Enyo Yoshio , Nakagawa Masafumi , Yamamoto Yoshio , Nakatani Tomohiro , Sakon Nana , Nagata Wakana , Nakagawa Yukihiro
Published: September 2022

Background

Although lumbar spinal stenosis (LSS) often coexists with other degenerative conditions, few studies have fully assessed possible contributing factors for low back pain (LBP) in patients with LSS. The purpose of this study was to identify factors associated with the severity of LBP in patients with LSS.

Methods

The patients with neurogenic claudication caused by LSS, which was confirmed by magnetic resonance imaging (MRI) were included in this cross-sectional study. Data included ratings of LBP, buttock and leg pain, and numbness on a numerical rating scale (NRS), 36-item Short-Form Survey (SF-36) scores, muscle mass measured by bioelectrical impedance analysis, and radiographic measurements including lumbopelvic alignment and slippage. The severity of LSS, endplate defects, Modic endplate changes, intervertebral disc degeneration, and facet joint osteoarthritis were evaluated on MRI. Spearman correlation and multivariate linear regression analyses were used to examine the factors associated with the severity of LBP (NRS score).

Results

A total of 293 patients (135 male and 158 female, average age 72.6 years) were analyzed. LBP was moderately correlated with buttock and leg pain, and buttock and leg numbness. Significant but weak correlations were observed between LBP and body mass index, appendicular and trunk muscle mass, all domains of SF-36, pelvic tilt, total number of endplate defects and Modic endplate changes, and summary score of disc degeneration grading, but not severity or number of spinal stenoses. In the multivariate regression analysis, age, female sex, trunk muscle mass, diabetes, NRS buttock and leg pain, NRS buttock and leg numbness, SF-36 vitality, pelvic tilt, and total number of endplate defects were associated with the severity of LBP.

Conclusions

Trunk muscle mass, lumbopelvic alignment, and endplate defects, but not severity of stenosis are partly associated with severity of LBP, but buttock and leg pain and buttock and leg numbness have strongest relationships with LBP in patients with LSS.