bluuebunny/crossref_metadata_2025 huggingface dataset:
A preliminary study on the mechanism of VASH2 in childhood medulloblastoma
Authors: Liu Wen , Fu Yinan , Wang Meng , Zhao Junhong , Chen Julin , Wang Yongxin , Qin Hu
Published: December 2022

Objective: To investigate the difference in VASH2 expression in tumor tissues of different molecular subtypes of pediatric medulloblastoma (MB), to analyze the correlation between VASH2 and molecular subtypes of medulloblastoma, clinicopathological data, and prognosis, and to explore the mechanism of VASH2's role in pediatric medulloblastoma.
Methods: We analyzed 47 pediatric medulloblastoma cases treated in the Department of Pediatric Neurosurgery of the First Affiliated Hospital of Xinjiang Medical University between January 2011 and December 2019, and detected the expression levels of YAP1 and GAB1 in these tumor tissues using immunohistochemistry (IHC), and performed molecular typing (WNT-type, SHH-type, non-WNT-type/SHH-type). To analyze the correlation between VASH2 and molecular subtypes of medulloblastoma. We focused on vasopressor 2 (VASH2) and investigated its biological role in DAOY cell proliferation, apoptosis, migration, invasion, and with the cell cycle by overexpressing and knocking down VASH2 in the medulloblastoma cell line DAOY, respectively, in vitro by small interfering RNA technology.
Results: 1. Among 47 pediatric medulloblastoma cases, 8 were WNT type, 29 were SHH type, and 10 were non-WNT/SHH type. the positive rate of VASH2 was highest in the SHH type with a 68.97% positive rate, followed by non-WNT/SHH and lowest in the WNT type. The results of the multifactorial analysis showed that positive expression of VASH2 was associated with medulloblastoma molecular subtype (SHH type), site of tumor development (four ventricles), and gender (male), P < 0.05.2 The results of cellular experiments showed that overexpression of VASH2 increased the invasion and migration ability of medulloblast Daoy, while knockdown of VASH2 inhibited the invasion and Overexpression of VASH2 upregulated the expression of Smad2+3, Smad4, Mmp2 and the apoptotic indicators Bcl-2 and Caspase3, while knockdown of VASH2 suppressed the expression of Smad2+3 and Mmp2, and silenced the expression of Smad4 and the apoptotic indicators Bcl2, Caspase3 expression. Flow cytometric cycle analysis showed that VASH2 overexpression increased the S phase in the Daoy cell cycle, while VASH2 knockdown decreased the S phase in the Daoy cell cycle.
Conclusion: We found for the first time that the positive expression rate of VASH2 was closely associated with SHH-type pediatric medulloblastoma, and VASH2 was involved in the invasion, migration, cell cycle, and apoptotic ability of the medulloblast cell line DAOY by affecting downstream indicators of the TGF-β pathway. It is suggested that it is involved in the progression of childhood medulloblastoma, and VASH2 is expected to be a diagnostic and therapeutic target for SHH-type childhood medulloblastoma.
The 3rd July 2019 paroxysm at Stromboli: insights into volcanic ballistics dispersion
Authors: Bisson M. , Spinetti C. , Gianardi R. , Strehlow K. , De Beni E. , Landi P.
Published: December 2022

High resolution dispersion of the ballistic projectiles erupted at Stromboli (Aeolian Archipelago, Italy) during the early phase of the 3rd July 2019 paroxysm was digitally reproduced and analysed. The paroxysms punctuate the persistent mild-explosive activity of Stromboli producing fallout of ballistic juvenile and lithic bombs that represent a serious threat for tourists climbing the volcano and for people living in the island. Drone images, acquired within a few days after the first 2019 paroxysm, were elaborated on GIS environment to identify and reproduce, as geo-spatial features, the ballistic spatter clasts emplaced on the volcano. The results indicate that 152,228 scattered spatter clasts, whose dimensions range from 0.03 m2(16 cm x 16 cm) to 4.23 m2(~ 2 x 2 m), were emitted on the east flank during the paroxysm. Such spatters represent the scattered clasts dispersed on 0.407 km2, and cover a total area of 29,000 m2corresponding to an erupted products volume of 6–7*103m3, calculated here for the first time. Further spatial and fitting analyses on spatter clasts distribution reveal the main dispersion trends of the ballistics, highlighting as the terrain morphology can influence the dynamic of the clasts emplacement.
Factors associated to patients’ referral to private Covid-19 healthcare centers in Tabriz, Iran
Authors: Jafari Nasrin , Akbari Hossein , Sarbakhsh Parvin , Dorosti Abbasali , Khayatzadeh Simin , Mohammadpoorasl Asghar
Published: December 2022

BackgroundIn Iran, tracking of patients and its associated data recording in private healthcare centers are poor, and thus a majority of patients suffering from Covid-19 are treated without any control on the isolation and quarantine processes. The present study aims to investigate the factors contributed to referral to private healthcare centers that provide Covid-19 care services.MethodsThis cross-sectional study was conducted from November 2021 to January 2022 in Tabriz, Iran. We invited a total of 258 and 202 Covid-19 patients from governmental and private healthcare centers, respectively, to participate in the study. Applying a self-administered questionnaire, we collected data on the reason of referring to the healthcare centers, patient’s waiting time, quality of healthcare services received by the patients, patients’ level of satisfaction, accessibility, insurance coverage, perceived severity of the disease, and the level of staff compliance from health protocols. Logistic regression model was used for data analysis.ResultsAdjusted for other variables, higher socio-economic status (OR=7.5), older age (OR=1.02), referral of friends and family members (OR=1.93), shorter waiting time (OR=1.02) and higher satisfaction (OR=1.03) were contributed to referral to private centers. Better accessibility (OR=0.98) and wider insurance coverage (OR=0.98) were also contributed to referral to governmental centers.ConclusionOlder age, higher socio-economic status, lower levels of waiting times for service provision, and higher levels of patient satisfaction were identified as determinant factors for patients’ referral to private healthcare centers. On the other hand, higher levels of accessibility to governmental healthcare centers and wider health insurance coverage reduced the possibility of referring to the private centers.
Identification of Hotspots in Synthetic Peptide Inhibitors of the FOXO4:p53 Interaction
Authors: Zhang Ran , Gao Kai , Sadremomtaz Afsaneh , Ruiz-Moreno Angel J. , Monti Alessandra , Al-Dahmani Zayana M. , Gyau Ben , Doti Nunzianna , Groves Matthew R.
Published: December 2022

Background:
Many stresses trigger cellular senescence, including telomere shortening, oncogene activation, DNA-replication stress, oxidative stress, and resistance to apoptosis. Forkhead box protein O4 (FOXO4) plays a pivotal role in cellular senescence, by binding to and inactivating p53, thereby leading to cellular senescence and inhibiting p53 mediated apoptosis. As a result, misregulation of FOXO4-p53 is linked to numerous diseases including cancers and aging-related diseases, pulmonary fibrosis and neurodegenerative diseases. Targeting of the FOXO4-p53 interface has been accomplished using a synthetic D retro inverse peptide (DRI), however recognition of the key molecular drivers of the interactions remains unknown. Understanding these interactions on a molecular level could lead to the development of small compounds, with enhanced pharmacological qualities, such as high stability, membrane permeability, and oral bioavailability, that mimics the activity of the DRI peptide.
Methods and Results:
Using an in silico model of the FOXO4-p53 interaction, we designed shorter peptides within the DRI to identify the key interactions. A biophysical assay demonstrates these shorter peptides retain strong binding affinity to p53, suggesting that the DRI's hot spot is located within these peptides.
Conclusions:
Taken together, this data provides information at the molecular level that is key to understanding the interplay of two proteins responsible for cellular senescence and provides the basis for the design of small molecules to inhibit this interaction.
Targeted inhibition of CD47 expression in Human cancer cell lines on treatment with Cardiac Glycosides
Authors: Kumavath Ranjith , Pavithran Honey
Published: December 2022

The interest has grown in therapeutically targeting Hypoxia-inducible factor 1α (HIFα), which directly stimulates the expression of cluster of differentiation 47 (CD47) on the cell surface that suppresses phagocytosis in cancer cells. Increased expressions of CD47 and counter interaction with signal regulatory protein alpha (SIRPα) enable cancer cells to avoid cell-mediated cell destruction. On the other side, decreased expression of SIRPα was reported to promote growth. Thus, colossal concern and curiosity arise in identifying the molecular mechanism behind this suppressive effect of CGs in controlling cancer cells. We first report that cardiac glycosides (CGs) inhibit HIFα and CD47 in human breast, lung, and liver cancer cells. Furthermore, our analysis through TCGA (The Cancer Genome Atlas) data shows that these three potential genes correlate with poor survival in breast, lung, and liver cancers. Our molecular docking and molecular dynamic simulations studies demonstrated the interaction of the mentioned CGs with target proteins and identified the stability. Importantly, unlike any other anti-CD47 antibodies, the antitumor activity of CGs has been evaluated in many cancers with no hematologic toxicities. These findings would help to develop clear strategies to target CD47 and SIRPα interaction through HIF1-α inhibitors to promote phagocytosis.
Contribution of computerization in the governance of Hospital structures : case of two Hospital Establishments in Mali
Authors: Dembélé Oumar , Bagayoko Cheick Oumar
Published: December 2022

Introduction
The place of information and communication technologies is well established in improving the quality of patient care.
While it is common ground that computerization brings added value in terms of health care, it is important to get a fairly precise idea of its contribution to hospital governance.
The study focused on two establishments:
- The National Center for Odonto-Stomatology (CNOS)
- The “Luxembourg” Mother-Child Hospital (MCH)
Objective
Determine the level of governance indicators before and after computerization
Method
This is a cross-sectional study to be evaluative to determine the contribution of computerization in the governance of the hospital. This contribution was determined by comparing the level of certain quality indicators before and after computerization. It took place from January 2016 to June 2019
Results
After computerization, the study showed that the out-of-stock rate of tracer drugs and consumables decreased by 94% at the MCH; Patient record keeping adequacy rate increased by 100% at CNOS and 62% at Children's; The average length of stay decreased by 70% at CNOS and 25% at the Children's; The user satisfaction rate increased by 19% at CNOS and 7% at the MCH.
Discussion
After computerization, the study showed that the out-of-stock rate of tracer drugs and consumables decreased by 94% at the MCH; Patient record keeping adequacy rate increased by 100% at CNOS and 62% at Children's; The average length of stay decreased by 70% at CNOS and 25% at the Children's; The user satisfaction rate increased by 19% at CNOS and 7% at the MCH.
Conclusion
The study clearly shows that computerization has had a contribution to certain indicators of the quality of care. The shortage rate of drugs and tracer consumables to be reduced by 94% at the Children's Hospital; Patient record keeping adequacy rate increased by 100% at CNOS and 62% at Children's; The average length of stay decreased by 70% at CNOS and 25% at the Children's; The user satisfaction rate increased by 19% at CNOS and 7% at the MCH.
Flexible Group Fairness Metrics for Survival Analysis
Authors: Sonabend Raphael , Pfisterer Florian , Mishler Alan , Schauer Moritz , Burk Lukas , Mukherjee Sumantrak , Vollmer Sebastian
Published: December 2022

Purpose: Algorithmic fairness is an increasingly important field concerned with detecting and mitigating biases in machine learning models. There has been a wealth of literature for algorithmic fairness in regression and classification however there has been little exploration of the field for survival analysis. Survival analysis is the prediction task in which one attempts to predict the probability of an event occurring over time. Survival predictions are particularly important in sensitive settings such as when utilising machine learning for diagnosis and prognosis of patients.
Methods: In this paper we explore how to utilise existing survival metrics to measure bias with group fairness metrics. We explore this in an empirical experiment with 29 survival datasets and 8 measures.
Results: We find that measures of discrimination are able to capture bias well whereas there is less clarity with measures of calibration and scoring rules.
Conclusion: We suggest further areas for research including prediction-based fairness metrics for distribution predictions.
How to choose “Good” Samples for Text Data Augmentation
Authors: Lin Xiaotian , Lin Nankai , Fu Yingwen , Yang Ziyu , Jiang Shengyi
Published: December 2022

Deep learning-based text classification models need abundant labeled data to obtain competitive performance. Unfortunately, annotating large-size corpus is time-consuming and laborious. To tackle this, multiple researches try to use data augmentation to expand the corpus size. However, data augmentation may potentially produce some noisy augmented samples. There are currently no works exploring sample selection for augmented samples in nature language processing field. In this paper, we propose a novel self-training selection framework with two selectors to select the high-quality samples from data augmentation. Specifically, we firstly use an entropy-based strategy and the model prediction to select augmented samples. Considering some samples with high quality at the above step may be wrongly filtered, we propose to recall them from two perspectives of word overlap and semantic similarity. Experimental results show the effectiveness and simplicity of our framework.
Microcystin-LR Detection in Freshwater Body by LC-MS/MS: Impediment for Water quality: Case study on Naharkhoran drinking water treatment plant
Authors: Halakoo Cobra , Emtyazjoo Mozhgan , Amoozegar Mohammad Ali , Nowroozi Jamileh , Saravi Hasan Nasrollahzadeh
Published: December 2022

Annual appearance of Microcystis blooming in superficial drinking water sources cause human poisoning in some places in the world, as they enter into DWTP (Drinking Water Treatment Plant) and bring into trouble in some of the water treatment stages. This research investigated attendance of MC-LR (Microcystin-LR) in aggregated samples from Naharkhoran DWTP pre and post-treatment where intake water from Ziarat River, as well as that correlation to some water quality parameters at the same time. Sampling was implemented into three-term (early & end summer and middle of autumn) from three stations: 1 input DWTP (raw water) and 2 output DWTP (pre & post chlorination). MC-LR was analyzed by LC/MS/MS (Liquid Chromatography/tandem Mass Spectrometry), other parameters were assayed by standard analytical methods. This effort is the first case study of MC-LR on Naharkhoran DWTP established downstream of Ziarat River to provide drinking water for Gorgan city residents, Iran. The MC-LR concentration in all of the samples was very low and below recommended national & global values. Fortunately, any MC-LR was observed in output DWTP at chlorinated water samples. Some of the other quality parameters measured below recommended national & global values and any were significant relationships between MC-LR with other parameters except pH which was inverse. Lack of MC-LR in the output of DWTP (treated water) post disinfection representative efficacious treatment and safe water for drinking.
Identifying new driver genes for castration resistance for prostate cancer based on protein mass spectrometry and transcriptome big data
Authors: Liu Wei , Zhou Xiaobei , Zhou Tingting , Zou Renlong , Wang Xiuxia , Liu Wensu
Published: December 2022

Purpose
Androgen is important in the formation, development and progress of prostate cancer. Deprivation of androgen, also named castration, is an effective way in prostate cancer therapies. For patients undergoing castration therapies, castration was gradually becoming ineffective in prostate cancer treatment and therefore resulting in castration resistance for prostate cancer, which is beyond efficient therapies. Moreover, the mechanism on how castration resistance was originated and what promoted castration resistance was rarely reported. We designed the project to further understand the mechanism for castration resistance.
Methods
AR-V7 and PRPF6 were selected to be calibration markers and then performed with protein mass spectrometry to detect AR-V7 and PRPF6 binding proteins. Afterwards, we used transcriptome big data from prostate cancer and castration-resistant prostate cancer and then applied combined analysis of association rules method, gene co-expression analysis, linear matrix migration method and functional deep filtering on identifying candidate driver genes which were causally correlated with castration resistance. The predicted driver genes were intersected with protein mass spectrometry filtering results for both AR-V7 and PRPF6. Afterwards, the predicted driver genes were theoretically and experimentally validated.
Results
The 5 candidate driver genes RPL28, RPS4X, RPL11, RPL23A and RPSA were deemed as driver genes for castration resistance and were validated on being highly correlated and playing important role in the progress of castration resistance.
Conclusion
The new driver genes might assist on further understanding the mechanism and bringing new insight on the prevention and therapy for castration resistance on prostate cancer.
Degradation of the cyanobacterial toxin anatoxin-a by a Bacillus strain in batch culture
Authors: Mohamed Zakaria A. , Mostafa Yasser , Alamri Saad , Hashem Mohamed , Alrumman Sulaiman
Published: December 2022

Anatoxin-a (ATX-a) is an alkaloid neurotoxin produced by certain species of cyanobacteria. It is water soluble and relatively stable in natural water, and thereby could present health hazards to human, animals and plants through prolonged exposure. Conventional water treatment methods are insufficient for ATX-a removal, and sometimes cause cell lysis and release on intracellular toxin. Biodegradation could be a promising method for removal of this toxin. This study addresses for the first time ATX-a biodegradation by Bacillus strain into a nontoxic byproduct (epioxy-ATX-a). The results showed that Bacillus strain AMRI-03 grew without lag phase in a lake water containing ATX-a.The strain also exhibited rapid ATX-a degradation, and the total degradation was initial- toxin-concentration–dependent.Total degradation of ATX-a occurred within 4 days at the highest two initial concentrations (50 & 100µg L− 1), compared to 6 and 7 days at lower concentrations (20, 10, and 1µg L− 1, respectively). Biodegradation rate by this bacterium also depended on initial ATX-a concentration, with highest value (12.5µg ATX L− 1 day− 1) recorded at the highest initial toxin concentrations (50 & 100µg L− 1). ATX-a biodegradation rate was influenced by temperature, with highest occurred at 25 and 30 ºC. pH also affected this rate, and the highest rates were obtained under neutral and slightly alkaline conditions (i.e., pH7 and 8). Both lower and higher pHs slowed the degradation rate. Being nontoxic, this bacterial strain could be applied in slow sand filters for degradation and removal of anatoxin-a in water treatment plants, after setting up mesocosm experiments to assess the potential effects of this bacterium on water quality.
Human papilloma virus profiles in breast cancer in correlation with Vitamin D
Authors: AZMI Hasna , SAIF Imane , NABIL Kawtar , MZIBRI Mohammed EL , BOUTAYEB Saber , ENNAJI Moulay Mustapha
Published: December 2022

The presence of the vitamin D receptor on the surface of breast tissue active results in terminal differentiation and inhibition of cell growth. The implication of vitamin D deficiency on cancer susceptibility found an association between low serum 25(OH) D3 levels and increased prevalence of breast cancer genesis. The risk factors incriminated in the genesis of breast cancer are well known, there is the involvement of certain oncogenic viruses, particularly HPV. In this, study 22 patients with breast cancer with a dosage of vitamin D less than normal with HPV infection. No significance between Clinicopathological parameters and vitamin D assay.
Examining Teachers’ Perceptions of E-Learning Tools: A Survey from Indonesian EAP Classrooms
Authors: Suherman Andri , Wathoni Hamzani
Published: December 2022

Given the fact that online teaching has been widely implemented across the globe during this Covid-19 pandemic, teachers are required to have a high level of IT skills to be able to conduct online teaching. It is without exception that EAP (English for Academic Purpose) teachers need to familiarize themselves with electronic devices due to the benefits they have to offer in an e-learning environment. The current study aims at examining teachers’ perceptions of using e-learning tools in the context of Indonesian EAP classrooms. Forty-five Indonesian EAP teachers participated in the current study with different ages, academic backgrounds, and lengths of EAP teaching experiences. The instruments used to collect the research data were an online survey and semi-structured interviews. The results showed that video and VLEs were the two most commonly-used e-learning tools among the teachers with “self-taught” and “colleagues” being the two most favorite approaches the teachers have employed to learn such tools. Besides, promoting student engagement and developing learner autonomy were perceived as positive impacts of using e-learning tools by the teachers. Pedagogical implications of this study’s findings suggested that school authorities should organize more regular pre-service teacher training programs with the purpose to help novice teachers to improve their IT skills. Besides, e-learning tools should be more used in online teachings due to the benefits they have to offer for promoting student engagement and facilitating learner autonomy. A number of limitations in the current study are also presented along with some suggestions for future studies
Exploring the Use of Padlet in Synchronous Learning: Students’ Perceptions of its Advantages and Disadvantages
Authors: Etfita Fauzul , Wahyuni Sri , Satriani Estika , Alber Alber , Asnawi Asnawi
Published: December 2022

As a result of the Covid-19 epidemic, educators in Indonesia have had experience dealing with synchronous learning, which has challenged them to select an interesting and engaging method, strategy, or tool to aid the teaching and learning process. Padlet was eventually chosen as the solution to this study. Padlet is a virtual wall that is used to build students' interest in learning English, specifically writing. In this study, the researchers used a descriptive quantitative research design with a sample of 96 students to assess their perceptions of using Padlet as a virtual wall. Numerous factors such as utility, knowledge, engagement, enjoyment, motivation, and ease of use were determined through a questionnaire-based survey which was then distributed as benefits and drawbacks of using Padlet. According to the findings, the students agreed that Padlet provided several benefits to their learning process. On the other hand, students disagreed with Padlet's disadvantages. Therefore, the result implied that the expectation to enhance knowledge is the major factor influencing students’ perceptions of the Padlet utilization in synchronous learning
Investigating the Digital Citizenship Levels of ELT Students within the Scope of Remote Learning
Authors: Şenel Müfit
Published: December 2022

It is obvious that using the Internet and technological tools became a ‘must’ throughout the Covid-19 pandemic period. All students and teachers started to use all those tools intensively both in their lessons and at their homes, and this process led to the digitalization of the classrooms and courses. Therefore, information and communication technologies (ICTs) and remote learning spread to all aspects of our lives and led to the emergence of a new concept, namely ‘Digital Citizenship’, making it significant to comprehend where students’ digital competence levels are. In line with this, the objective of this research was to investigate the digital citizenship levels of the participants and how much they are knowledgeable about being conscious digital citizens. Totally, 196 students from an ELT department of a state university in Turkey participated in the study. The study was carried out with a quantitative research method in the 2021-2022 spring semester, and data were collected through the 5-point Likert type “Digital Citizenship Scale”. Responses were evaluated by SPSS v26 statistical package program and based on the findings, it was indicated that almost all dimensions of digital citizenship were met by the participants. Since there was almost no statistically significant in terms of gender, age, and grade variables, the highest dimensions were found at digital commerce and digital responsibility levels.  This current study will pay the way for educators, instructors, curriculum designers, and materials developers to review, redesign and reevaluate the existing language teaching programs. Students will also be aware of their weaknesses and strengths about digital citizenship and realize the significance of the concept of digital citizenship.
Ensuring Teaching Continuity: Chilean University Students’ Perception on Remote Teaching of English during COVID 19 Pandemic
Authors: Hsu Chuan Chih , Su Chia Shih , Su Kau I
Published: December 2022

The objective of our study is to know the perception of Chilean university students toward the pedagogical methodologies in online English classes during the COVID-19 pandemic. We applied a questionnaire (built by fifteen experts, validated through a pilot test of 34 students, and improved with licensed 21.0 version SPSS in terms of consistency) to 341 students from different university programs. We analyzed the responses quantitatively and qualitatively and found out that 75% of the 341 students surveyed have shown agreement with the pedagogical methodologies applied in online classes and motivation in learning due to the permanent concern and communication of the teacher in charge. Besides, the students have also yielded satisfactory learning outcomes. These results reveal that the online English teaching of Chilean higher education during the pandemic has been good and indirectly show the willingness of Chilean university teachers to receive relevant and continuous training to deliver quality education. In 2022, many countries have returned to face-to-face classes, but we believe that the pedagogical methodologies used in this research could serve as a reference for teachers or researchers worldwide who wish to incorporate into their face-to-face classes a part of online teaching and do research on online English teaching.
Geografia, (des)interesse e (des)conhecimento em períodos de ultradireita
Authors: Carneiro Rosalvo Nobre
Published: December 2022

A Geografia se institucionalizou na segunda metade do século XIX, na Alemanha e na França, como uma ciência empírico-analítica. Entre 1950 e 1970 se constituiu como uma ciência histórico-hermeneútica e, em seguida, como uma ciência crítica. No Brasil, o saber geográfico atravessou diferentes períodos históricos marcados pela ultradireita. Diante disso, procura-se interrogar em que medida, com o retorno ao ultraconservadorismo pós-Golpe de Estado de 2015 no Brasil, o interesse emacipatório que orienta as ações na área da Geografia acadêmica e escolar sofre um desinteresse político em detrimento do interesse técnico e atrelado aos seus saberes? Neste contexto, objetiva-se analisar a relação entre interesse e conhecimento da ciência geográfica em períodos de conservadorismo e antidemocracia.Trata-se de pesquisa bibliográfica, considerando-se a periodização das escolas de pensamento geográfico positivista, funcionalista e crítico-marxista. Foca-se nas aproximações entre o papel da Geografia escolar e o desenvolvimento do campo acadêmico da Geografia. Como resultados, verifica-se quanto às duas primeiras escolas de pensamento uma apropriação política do saber espacial mediante interesses técnico para a construção da identidade nacional, da ideologia patriótica e do desenvolvimentismo, no contexto de governos de ultra-direita ditatoriais. Conclui-se, porém, que com o governo de  extremadireita eleito democraticamente mediante em 2018, verifica-se um desinteresse pelo conhecimento geográfico academico, isto é do territorio nacional, e um deficit na perspectiva crítica do ensino nas escolas pela via indultora da BNCC.
caso de “homens infames"
Authors: Pagliarini Mariângela Nascimento , Lima Marcia Heloisa Tavares de Figueredo
Published: December 2022

Estudo bibliográfico, teórico-exploratório sobre memória institucional e sua complexa relação com a memória histórica nacional. Teve por objetivo geral contribuir para a reflexão acerca do modo como a biblioteca do Tribunal de Justiça Militar do Rio Grande do Sul poderia analisar documentos sensíveis para organizar, preservar e disseminar as informações contidas nos processos judiciais históricos atinentes a fatos ocorridos de 1964 a 1985 de forma a torná-las disponíveis para pesquisas futuras. Apresenta breve reflexão sobre memória institucional e sua tensão frente à memória/história. Mostra, como exemplos de processos judiciais sensíveis relevantes, os que foram instaurados durante o regime de exceção de 1964, e alcançaram os chamados grupos “Os Onze da Brigada”, utilizando a metáfora dos “homens infames” de Michel Foucault. Por fim, postula a pertinência de manutenção deste tipo de processo para evitar o apagamento das informações e proporcionar futuras pesquisas. Reconhece lacunas não respondidas acerca da organização propriamente dita deste acervo, motivadas pelo período de fechamento das instituições no contexto da COVID-19, pandemia mundial, e aponta para a conveniência de prosseguimento da pesquisa ou novas pesquisas no rico acervo.
Da economia circular à ecologia das redes
Authors: Preger Guilherme de Figueiredo
Published: December 2022

Este artigo aborda a mudança de paradigma para a noção de trabalho na sociedade impactada pela transformação digital. Reformulando o conceito de trabalho como transformação conservadora de energia, de acordo com a primeira lei da termodinâmica, para o entendimento do trabalho como redução da entropia, conforme a segunda lei, é possível compatibilizá-lo com os conceitos de informação e de comunicação. O artigo sugere que esta reformulação já estava implícita na teoria marxista e a diferencia do modelo ricardiano clássico.  A transformação digital é pensada como corte epistemológico no modo de produção, que traz consequências para o sistema funcional da economia. Neste, o modo dominante da economia capitalista (o capitalismo de plataforma) é confrontado com modos alternativos como o da Economia Solidária. O artigo examina se a transformação digital traz vantagens comparativas para a Economia Solidária e conclui positivamente neste sentido.
teoria do agir comunicativo de Habermas na administração de organizações
Authors: Lima Clóvis Ricardo Montenegro de , Lima José Rodolfo Tenório , Carvalho Lidiane dos Santos , Sanches Neto Asy Pepe , Titonelli Anderson
Published: December 2022

Neste artigo mostra-se os resultados de uma busca em bases de dados internacionais sobre a teoria do agir comunicativo de Habermas na área da Administração de Organizações.  A teoria de Habermas foi desenvolvida após a sua guinada linguística, de ruptura com a filosofia da consciência e a metafísica em 1981. Nela os usos da linguagem são modos de expressão e representação, mas também modo de construção de vínculos sociais. A partir desta teoria, Habermas desenvolve a ideia de discurso como agir comunicativo orientado para o entendimento, e elabora uma ética do discurso e uma política deliberativa. A entrada da obra de Habermas na Administração antecede a sua guinada linguística, e deve ser destacado o uso da sua tese "Mudança estrutural da esfera pública". Neste artigo quer-se destacar as relações estabelecidas entre a filosofia da linguagem e a Administração, tanto em acordos teóricos quanto práticos. Entre os aspectos teóricos destaca-se os estudos teóricos do conhecimento, incluindo a epistemologia. Entre os aspectos práticos estão as questões da filosofia prática, a ética e a política. Quer-se assim apresentar o potencial da filosofia de Habermas para pesquisa e trabalho na Administração de Organizações.
princípio de universalização na teoria discursiva de Jürgen Habermas
Authors: Brandão André Guimarães Borges
Published: December 2022

O presente artigo científico é parte de pesquisa destinada a investigar as implicações e interpretações advindas da transformação do posicionamento do princípio de universalização (U) operada na teoria do discurso do filósofo alemão Jürgen Habermas, sobretudo a partir de algumas de suas obras das décadas de 80 e 90. A pretensão cognitivista da ética do discurso fundamenta a moral diante da possibilidade de reconstrução racional discursiva das justificativas das normas. O teste de universalização faz parte da fundamentação, mas em que sentido? A fim de afastar o ceticismo quanto a pretensão de justificação prática, Habermas repensa a relação kantiana entre moral e direito. Mais precisamente, diante de sociedades complexas marcadas pelo Estado Democrático de Direito e pelo uso de discursos práticos diversos da moral para a justificação das práticas sociais, a legitimidade das normas passa por explicitar a relação discursiva entre direito, moral e política. É no âmbito deste desafio que o filósofo alemão vem modificando a formulação e o posicionamento de seu princípio de universalização (U) ao longo do tempo, bem como sua relação com o princípio do discurso (D) e, posteriormente, com o princípio da democracia (De). Após percorrermos este caminho, lançamos a hipótese, segundo a qual, a ênfase que Habermas confere ao direito em Facticidade e Validade junto do reposicionamento do ponto de vista moral, permite pensar de maneira dialógica a interação social como práxis comunicativa sem sujeitos
An Application of EJSCREEN for the Examination of Environmental Justice in Metropolitan Areas of Ohio, USA
Authors: Kumar Ashok , Kuruppuarachchi Lakshika Nishadhi , Harsha Madiraju Saisantosh Vamshi
Published: December 2022

Over the past few decades, the notion of Environmental Justice (EJ) in the
United States has grown. Many empirical studies prove how low-income and minority
neighborhoods are excessively exposed to environmental burdens. This chapter aims to
present an approach to identifying EJ concerns facing minority and low-income
populations in the metropolitan areas in Ohio by analyzing their distribution using
EJSCREEN, a screening and mapping tool developed by the USEPA. Twelve
metropolitan areas were considered to examine environmental and demographical
information. The metropolitan areas are integrated geographic regions comprised of at
least one city or urban area and adjacent communities. In assessing the demographic
inequalities and environmental risk in the regions of the metropolitan areas, the
EJSCREEN tool was used to generate EJ standard reports for all the zip codes in the
metropolitan areas. Two-sample t-test results indicate that diesel PM, hazardous waste,
RMP sites, lead paint, traffic proximity, respiratory hazard risk, and air toxic cancer
risk are significantly higher in areas where a higher proportion of low-income and
minority populations live than the areas with a lower proportion with low-income and
minority populations. These environmental indicators are directly associated with air
pollution.
Assessment of Ground Water Quality Using GIS Techniques
Authors: Naveen B.P. , Divya K.S.
Published: December 2022

In the present study, the groundwater quality was tested around the
Gandhinagar sub-watershed covering a neighborhood of 53.63 sq. km, which lies
between north latitudes 12°46′ and 13°58′ and east longitudes 77°21′ and 78°35′ within
the state of Karnataka, India. For the study, data collection includes maps, toposheets,
water quality data, well locations, village locations, etc. The above-said data has been
collected from various government departments of Karnataka. After the data collection,
the base map was prepared using ArcMap. The water samples have been tested and
then used as an attribute database to design thematic maps showing various water
quality parameters.
Threats to Sustainability of Land Resources Due to Aridity and Climate Change in the North East Agro Climatic Zone of Tamil Nadu, South India
Authors: Dhanya P. , Ramachandran A. , Palanivelu K.
Published: December 2022

Focusing on the erstwhile Chengalpattu district, north-east agro-climatic zone of Tamil Nadu region, this research aimed to assess the changes in spatiotemporal patterns and trends of the extreme climatic events and aridity conditions during the period 1971-2000. The trend analysis of the observed climatic parameters was carried out using R software and Mann-Kendall non-parametric test. A statistically significant increasing trend was noted in the warm spell duration (wsdi) and heavy rainfall events (r20mm). The results revealed that Aridity Index (AI) has significant negative trends in northeast monsoon and winter seasons, indicating dryness, and positive trends in southwest monsoon seasons, indicating wet climate. The trends in MI were found to be mostly negative during the southwest monsoon season. The results of the trend analysis in PET revealed a significant increase annually and seasonally. Overall, spatial analysis characterized the western parts as semi-arid, whereas a dry sub-humid climate prevails in the eastern parts, covering the coastal areas. As per the outcome, there may be escalations of 19.5 to 25.7% in PE in the study area. Parts of Kancheepuram, Sriperumbudur, Chengalpattu, Thirukazhikundram, Maduranthakam, and the whole of Uthiramerur blocks are going to be severely impacted due to the rise of PE. This may further trigger an escalation of aridity processes in the future and pose threats to the sustainability of land resources.
Mathematical Analysis of a Rumor Spreading Model within the Frame of Fractional Derivative
Authors: Baishya Chandrali , Achar Sindhu J. , Veeresha P.
Published: December 2022

Rumor spreading is a trivial social practice, which has a long history of
affecting society both in a positive and negative way, and modelling of transmission
of rumors has been an attractive area for social and, of late, for physical scientists. In
this chapter, we have modified the rumor-spreading model by incorporating fractional
derivatives in the Caputo sense. To analyze the spread of rumors in social as well as
virtual networks, we have considered four populations, namely, ignorant, spreader,
recaller, and stifler. The existence and uniqueness, and boundedness of the solutions
of the present model have been exhibited theoretically. Numerically, we have
experimented with the effect of fractional derivatives and the density of one
population on the other population by demonstrating the impact of rumor spread with
the change of various parameters.
Analysis of Organizational Commitment and Leadership Style as Moderation Variables in Achieving Managerial Performance
Authors: Nahar Aida
Published: December 2022

AbstractThis study aims to analyze the moderating variables that affect the managerial performance of furniture companies in Jepara district. Managerial performance is achieved if the planning involves the participation of employees. Management and employees jointly design company plans. Therefore, this study examines whether budgetary participation affects managerial performance. In addition, the moderating variables of organizational commitment and leadership style were investigated in this study to strengthen the influence of budgetary participation on managerial performance. The population of this study was managers and employees of furniture companies in Jepara district, amounting to 77,817.The sampling technique was random sampling method and the technique of data analysis used moderated regression analysis. The result reveals that managerial performance is influenced by budgetary participation if there is organizational commitment and depends on the company's leadership style.  Keywords: Budgetaryparticipation; Organizational commitment; Leadership style; and managerial performance Analisis Komitmen Organisasi dan Gaya Kepemimpinan Sebagai Variabel Moderasi dalam Pencapaian Kinerja Manajerial AbstrakPenelitian ini bertujuan untuk menganalisis variabel moderasi yang mempengaruhi kinerja manajerial perusahaan mebel di kabupaten Jepara. Kinerja manajerial tercapai jika perencanaan melibatkan partisipasi karyawan. Manajer dan karyawan bersama-sama merancang rencana perusahaan. Oleh karena itu, penelitian ini mengkaji apakah partisipasi penyusunan anggaran berpengaruh terhadap kinerja manajerial. Selain itu, komitmen organisasi dan gaya kepemimpian diteliti dalam penelitian ini untuk menguji apakah dapat memperkuat pengaruh partisipasi anggaran terhadap kinerja manajerialnya. Populasi dalam penelitian ini adalah manajer dan karyawan perusahaan mebel di kabupaten Jepara yang berjumlah 77.817 orang. Teknik pengambilan sampel menggunakan metode random sampling dan teknik analisis data menggunakan analisis regresi moderasi. Hasil penelitian ini adalah efektivitas bisnis dipengaruhi oleh partisipasi anggaran jika ada komitmen organisasi dan tergantung pada gaya kepemimpinan perusahaan Kata kunci: Partisipasi Anggaran, Komitmen Organisasi, Gaya Kepemimpinan, dan Kinerja Manajerial
INNOVATION MANAGEMENT SYSTEM MODEL OF STATE CIVIL SERVICES USING SOFT SYSTEM METHODOLOGY APPROACH
Authors: Soesanto Hari
Published: December 2022

The innovations in the public sector in Indonesia produced by the state civil apparatus have not been fully managed systematically and integrated. Several Ministries and Institutions, as well as Local Governments, have made efforts to facilitate the innovation ecosystem even though there has been no connectivity and innovation platform integration together. The problems that occur in the management of innovation in the public sector are different from those of the private sector, especially in the aspects of the complexity of the problem, uncertainty, and the capacity of bureaucratic innovation. These problems require a different approach to studying them. One approach that is suitable for studying complex, uncertain, unstructured, and involving human social activities is the systems thinking approach, especially the Soft System Methodology (SSM). This study aims to formulate a conceptual model of the innovation management system produced by the state civil apparatus, especially civil servants in Indonesia, through the Soft System Methodology. The research results will be useful for policymakers, especially agencies that have the task and function of encouraging innovation for the government sector (public sector) in Indonesia at both the central and local government levels.
PUBLIC POLICY AND SPECIAL AUTONOMY IN PAPUA AND WEST PAPUA
Authors: Suharno Suharno
Published: December 2022

Serious efforts to decentralize Indonesia have only been carried out since the reformation period began in the midst of the crisis that hit Asia and coincided with the process of changing leadership in Indonesia from Suharto to Habibie. Regional autonomy is considered to be able to answer the demands of equitable distribution of socio-economic development, governance, and the development of an effective political life because it is believed to be able to guarantee the handling of community demands in a varied and fast manner. Article 18B of the 1945 Constitution of the Republic of Indonesia recognizes and respects special or special regional government units which are regulated by law. The special autonomy implemented in Indonesia can be categorized as asymmetric decentralization, including Papua and West Papua. Politically, the issue of Papua Autonomy has gained light and legitimacy as well as a normative basis with the issuance of the Special Autonomy Law, but in reality the implementing regulations are not perfect. A grounded public policy is needed that takes into account the aspirations of the people of Papua and West Papua with the Special Autonomy Law as a normative basis because the actual role of the Special Autonomy Law in the welfare of the people of Papua and West Papua is as legalization to manage Papua and West Papua in particular by taking into account the various characteristics that they have. towards progress and prosperity.
EFFECTIVENESS OF ADDITION OF METFORMIN TO STATIN THERAPY FOR PRODIABETOGENIC CHANGES CORRECTION IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBESITY
Authors: Koval Sergiy , Mysnychenko Olga , Penkova Maryna , Lytvynova Olga , Berezin Oleksandr
Published: December 2022

The aim: to study the effectiveness of adding metformin to statin therapy to correct prodiabetogenic changes in patients with arterial hypertension (AH) and abdominal obesity (AO).
Materials and methods. We examined 65 patients with 2-3 degrees of AH in combination with AO of I-II degrees, atherogenic dyslipidemia and insulin resistance (IR) aged 47-59 yrs: group 1 – 35 patients who were treated with statins (atorvastatin) against the background of standard combinations of antihypertensive drugs, metformin was added; group 2 – 30 patients who did not receive metformin. The examination included generally accepted methods. Statistical data analysis was carried out using standard methods using Microsoft Excel 7.0 and SPSS 19.0 application packages.
Results. The addition of metformin to atorvastatin against the background of standard antihypertensive therapy and recommendations for the normalization of lifestyle allowed a significant reduction in IR and the incidence of prediabetes in hypertensive patients with AO after 16 weeks of treatment. In patients who did not receive metformin, there was no decrease in these indicators. In the group of patients who used metformin, a significantly higher frequency of achieving target blood pressure levels was revealed than in the group of patients in whom this drug was not used.
Conclusions. The effectiveness of the use of the insulin sensitizer metformin for the correction of pro-diabetogenic changes associated with statin therapy in patients with AH, which occurs against the background of AO, atherogenic dyslipidemia, and IR, has been shown.
Book Review: Cosplay: The Fictional Mode of Existence
Authors: Berge PS
Published: December 2022

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Plot Patterns in Manga Based on Propp’s narratological elements
Authors: Groza Bogdan , Momanu Adrian
Published: December 2022

This article takes into consideration Vladimir Propp’s work on narratological elements and applies them to the narrative strategies of manga. Through a generalization of Propp’s scheme, an in-depth explanation of how they interact with one another and the addition of several new functions, this work demonstrates that these categories are functional in the study of the narratological elements found in manga. For the purpose of this article, most of the provided examples derive from shōnen manga as they provide for a clearer analysis. The secondary aim is to emphasize that there is room for critical analysis in manga, one that is directly correlated with literature. This medium that combines literature and art, other than having its own history, has evolved along the decades and adapted to the requirements of its generation; it is hence important to acknowledge and value a possible analytical approach.