American Gut: an Open Platform for Citizen Science Microbiome Research
Authors: McDonald Daniel , Hyde Embriette , Debelius Justine W. , Morton James T. , Gonzalez Antonio , Ackermann Gail , Aksenov Alexander A. , Behsaz Bahar , Brennan Caitriona , Chen Yingfeng , DeRight Goldasich Lindsay , Dorrestein Pieter C. , Dunn Robert R. , Fahimipour Ashkaan K. , Gaffney James , Gilbert Jack A. , Gogul Grant , Green Jessica L. , Hugenholtz Philip , Humphrey Greg , Huttenhower Curtis , Jackson Matthew A. , Janssen Stefan , Jeste Dilip V. , Jiang Lingjing , Kelley Scott T. , Knights Dan , Kosciolek Tomasz , Ladau Joshua , Leach Jeff , Marotz Clarisse , Meleshko Dmitry , Melnik Alexey V. , Metcalf Jessica L. , Mohimani Hosein , Montassier Emmanuel , Navas-Molina Jose , Nguyen Tanya T. , Peddada Shyamal , Pevzner Pavel , Pollard Katherine S. , Rahnavard Gholamali , Robbins-Pianka Adam , Sangwan Naseer , Shorenstein Joshua , Smarr Larry , Song Se Jin , Spector Timothy , Swafford Austin D. , Thackray Varykina G. , Thompson Luke R. , Tripathi Anupriya , Vázquez-Baeza Yoshiki , Vrbanac Alison , Wischmeyer Paul , Wolfe Elaine , Zhu Qiyun ,   The American Gut Consortium, Knight Rob , Mann Allison E. , Amir Amnon , Frazier Angel , Martino Cameron , Lebrilla Carlito , Lozupone Catherine , Lewis Cecil M. , Raison Charles , Zhang Chi , Lauber Christian L. , Warinner Christina , Lowry Christopher A. , Callewaert Chris , Bloss Cinnamon , Willner Dana , Galzerani Daniela Domingos , Gonzalez David J. , Mills David A. , Chopra Deepak , Gevers Dirk , Berg-Lyons Donna , Sears Dorothy D. , Wendel Doug , Lovelace Elijah , Pierce Emily , TerAvest Emily , Bolyen Evan , Bushman Frederic D. , Wu Gary D. , Church George M. , Saxe Gordon , Holscher Hanna D. , Ugrina Ivo , German J. Bruce , Caporaso J. Gregory , Wozniak Jacob M. , Kerr Jacqueline , Ravel Jacques , Lewis James D. , Suchodolski Jan S. , Jansson Janet K. , Hampton-Marcell Jarrad T. , Bobe Jason , Raes Jeroen , Chase John H. , Eisen Jonathan A. , Monk Jonathan , Clemente Jose C. , Petrosino Joseph , Goodrich Julia , Gauglitz Julia , Jacobs Julian , Zengler Karsten , Swanson Kelly S. , Lewis Kim , Mayer Kris , Bittinger Kyle , Dillon Lindsay , Zaramela Livia S. , Schriml Lynn M. , Dominguez-Bello Maria G. , Jankowska Marta M. , Blaser Martin , Pirrung Meg , Minson Michael , Kurisu Mike , Ajami Nadim , Gottel Neil R. , Chia Nicholas , Fierer Noah , White Owen , Cani Patrice D. , Gajer Pawel , Strandwitz Philip , Kashyap Purna , Dutton Rachel , Park Rachel S. , Xavier Ramnik J. , Mills Robert H. , Krajmalnik-Brown Rosa , Ley Ruth , Owens Sarah M. , Klemmer Scott , Matamoros Sébastien , Mirarab Siavash , Moorman Stephanie , Holmes Susan , Schwartz Tara , Eshoo-Anton Tifani W. , Vigers Tim , Pandey Vineet , Treuren Will Van , Fang Xin , Zech Xu Zhenjiang , Jarmusch Alan , Geier Justin , Reeve Nicolai , Silva Ricardo , Kopylova Evguenia , Nguyen Dominic , Sanders Karenina , Salido Benitez Rodolfo Antonio , Heale Arthur Cole , Abramson Max , Waldispühl Jérôme , Butyaev Alexander , Drogaris Chris , Nazarova Elena , Ball Madeleine , Gunderson Beau 
Published: May 2018

We show that a citizen science, self-selected cohort shipping samples through the mail at room temperature recaptures many known microbiome results from clinically collected cohorts and reveals new ones. Of particular interest is integratingn= 1 study data with the population data, showing that the extent of microbiome change after events such as surgery can exceed differences between distinct environmental biomes, and the effect of diverse plants in the diet, which we confirm with untargeted metabolomics on hundreds of samples.