bluuebunny/crossref_metadata_2025 huggingface dataset:
Duration of anti-tissue transglutaminase normalization after starting a gluten-free diet in children with celiac disease
Authors:   Shiraz University of Medical Sciences, Shiraz, Iran, Dehghani S.M. , Anbardar M.H. ,   Shiraz University of Medical Sciences, Shiraz, Iran, Shahramian I. ,   Shiraz University of Medical Sciences, Shiraz, Iran, Aran M. ,   Shiraz University of Medical Sciences, Shiraz, Iran, Hamzeloo S. ,   Shiraz University of Medical Sciences, Shiraz, Iran, Fazeli F. ,   Shiraz University of Medical Sciences, Shiraz, Iran, Rakhshaninasab S. ,   Zabol University of Medical Sciences, Zabol, Iran, Tahani M. ,   Zabol University of Medical Sciences, Zabol, Iran
Published: March 2023

The aim of the present study was to investigate the time required for the normalization of anti-tissue transglutaminase antibodies IgA (anti-TTG IgA) after starting a gluten-free diet (GFD) in children with celiac disease (CeD). This study included 59 children under 18 years of age with a confirmed diagnosis of CeD referred to Imam Reza Clinic affiliated with Shiraz University of Medical Sciences. All children were divided into two groups, including those with either <180 or >180 U/mL anti-TTG IgA levels. The titer of anti-TTG IgA was checked after the start of GFD. Data analysis was performed using a SPSS software (version 21). The shortest time of anti-TTG IgA normalization was acquired three months after the start of GFD, while the longest time was 30 months. The total average time of normalization was 12.28 ± 6.48 months. The average periods of normalization in patients with baseline anti-TTG IgA titers of <180 and >180 U/mL were 11.30 ± 6.12 and 13.82 ± 6.86 months, respectively (P > 0.05). According to our results, the duration for normalization of anti-TTG IgA levels after GFD initiation was independent of the baseline antibody titer at the time of diagnosis. Key words: normalization time, transglutaminase, gluten-free diet, celiac disease.
Joubert syndrome in a child with Gilbert syndrome
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Sergeeva E.I. , Chekh S.M. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Ipatova M.G. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation,   N.F.Filatov Children’s City Clinical Hospital, Moscow Healthcare Department, Moscow, Russian Federation, Shumilov P.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: March 2023

Joubert syndrome is a heterogeneous disease from a group of ciliopathies that share a specific malformation of the midbrain and hindbrain, known as the «molar tooth sign» according to MRI of the brain. This article presents a clinical case of a rare hereditary disease – Joubert syndrome caused by mutations of C.610A>G in the OFD1 gene. The history of the disease was traced to the age of 6 years 9 months. Clinical manifestations of the disease in the patient since birth were jaundice, respiratory disorders, diffuse hypotonia, convergent strabismus, delayed physical and psychomotor development. After excluding the main groups of hereditary metabolic diseases, the patient underwent a brain MRI, where a specific anomaly of the cerebellar and brainstem structure, known as the «molar tooth sign», was revealed. Subsequently, the diagnosis was clarified by the molecular genetic method (Sanger sequencing). Key words: children, Joubert syndrome, ciliopathy, OFD1 gene
The Use of ICT and the Realistic Mathematics Education on Learning Functions to Develop Algebraic Thinking Skills
Authors: Hajizah Mimi Nur , Dwi Antari Wijayanti
Published: March 2023

The concept of function has evolved into one of the most fundamental principles in modern mathematics, influencing practically every area. However, it proved to be one of the most difficult ideas to grasp in mathematics. The concept of function is frequently taught without any connection to real-life situations. Students must work with problem scenarios that happen in a variety of contexts that are relevant to their everyday lives or make sense to them in order to gain authentic comprehension. This is consistent with the RME's properties. The unwillingness to highlight the visual element of the notion is one of the major roadblocks in learning functions. Using ICT and an RME approach to learning functions as an alternative to overcome these barriers could be a viable option. ICT and RME can help students learn mathematical principles in function content by providing a clearer visual experience. The purpose of this study is to investigate how ICT and RME can be used to improve learning function and increase algebraic thinking skills. This study conducted in a classroom of 29 junior high school students at the eighth grade. Design research methodology was used in this study by conducting three phases: preliminary design, teaching experiment, and retrospective analysis.
Pengaruh Pendekatan Kontekstual dengan Strategi Think Talk Write terhadap Kemampuan Pemecahan Masalah Matematis Siswa SMA Negeri 1 Jakarta
Authors: Ahmad Yadih  , Ellis Salsabila  , Tri Murdiyanto
Published: March 2023

Tujuan dari penelitian ini adalah untuk menguji pengaruh pendekatan kontekstual dengan strategi Think Talk Write (TTW) terhadap kemampuan pemecahan masalah matematis siswa. Metode yang digunakan pada penelitian ini adalah penelitian eksperimen semu dengan post-test only control group design. Teknik pengambilan sampel menggunakan teknik cluster random sampling dan simple random sampling. Sampel penelitian yaitu siswa kelas XI MIPA 5 dan XI MIPA 4 di SMA Negeri 1 Jakarta. Kemampuan pemecahan masalah matematis siswa diukur menggunakan instrumen penelitian yaitu empat soal uraian pada pokok bahasan program linear yang telah valid dan reliabel. Hasil pengujian hipotesis menggunakan uji-t dengan taraf signifikansi , diperoleh bahwa  dan  sehingga   , maka  ditolak dan nilai Cohen’s d diperoleh perhitungan sebesar yang termasuk ke dalam kategori Large (besar) dengan presentase sebesar 79%. Berdasarkan hasil perhitungan, dapat disimpulkan terdapat pengaruh positif yang signifikan dari penerapan pendekatan kontekstual dengan strategi think talk write terhadap kemampuan pemecahan masalah matematis siswa kelas XI SMAN 1 Jakarta.
PELATIHAN KETERAMPILAN BERBAHASA INDONESIA BAGI MAHASISWA ASING ALUMNI PROGRAM DARMASISWA UNIVERSITAS NEGERI JAKARTA
Authors: Purbarani Etsa , Muliastuti Liliana , Diyantari
Published: March 2023

Fakultas Bahasa dan Seni Universitas Negeri  Jakarta (FBS-UNJ) sejak 1999 menerima mahasiswa asing belajar bahasa Indonesia sebagai implikasi kerja sama FBS-UNJ dengan perguruan tinggi di Korea Selatan. Selain itu, FBS-UNJ juga menyelenggarakan program Darmasiswa yaitu program bahasa Indonesia bagi penutur asing (BIPA) dengan beasiswa dari Kementerian Pendidikan Kebudayaan, Riset, dan Teknologi.  Saat ini lulusan program BIPA  Darmasiswa FBS-UNJ telah bekerja di berbagai negara. Di antara mereka ada yang menggunakan bahasa Indonesia sebagai alat komunikasi dalam bekerja. Pelatihan ini dilaksanakan untuk menyegarkan dan meningkatkan keterampilan berbahasa Indonesia mereka setelah beberapa tahun selesai belajar di UNJ.  Pelatihan dilaksanakan selama dua minggu secara virtual karena lokasi tinggal para alumni yang berbeda-beda. Materi yang dilatihkan meliputi empat keterampilan berbahasa, yaitu keterampilan menyimak, keterampilan berbicara, keterampilan membaca, serta keterampilan menulis. Materi yang dikembangkan untuk kegiatan ini merupakan materi singkat untuk dua minggu. Semua materi mengacu pada Standar Kompetensi Lulusan (SKL) yang tertuang dalam Permendikbud Nomor 27 tahun 2017. Tugas akhir peserta kegiatan pelatihan ini berupa tulisan dengan tema Pandemi 19.  Setelah dianalisis teridentifikasi terjadi peningkatan kemampuan peserta pelatihan dalam kemampuan menulis.
Factors improved clinical outcomes in patients < 38 years with diminished ovarian reserve and low oocyte retrieval: a retrospective study
Authors: Chen Xiao-Jun , Xi Ji , Liu Han , Pan Jiexue , Zhou Cheng-Liang , Jin Li
Published: March 2023

Background: In young patients with Diminished ovarian reserve (DOR), the number of retrieved oocytes limits the success of assisted reproductive technology, but which factors influence the clinical outcome of young DOR patients who already have retrieved few eggs is still unclear.
Methods: We retrospectively analyzed clinical date of 349 young DOR patients (< 38 years old and FSH >10IU/L) with low oocyte retrieval (≤ 5 oocytes).
Results: Total of 18 candidate variables were tested. Seven factors were identified as being significantly different (P < 0.05) between the clinical pregnancy group and the non-clinical pregnancy group. six factors were significantly different between the live-birth group and the non-live birth group. In multivariate analysis, lower antral follicle count (AFC) and estradiol (E2) level on hCG day were independent negative risk factors associated with the outcome of clinical pregnancy, as well as live birth. Lower progesterone (P) on hCG day was associated with a higher rate of clinical pregnancy and live birth.
Conclusions: Our study indicated that AFC, E2 on hCG day, and P on hCG day are prognostic factors for clinical pregnancy and live birth rates in young DOR patients with low oocyte retrieval.
The Effectiveness of Applying the Economic and Technological of the Kingdom of Saudi Arabia's Vision 2030 Dimensions in Achieving the Competitive Advantage of the Hail Region
Authors: Alhamad Samer Hussein Imfadhi , DAKHLI Abdesselem Chedli , Hani Sylvia Ismail Bani , Almahayreh Abdulah salamah
Published: March 2023

The research aims to evaluate the effectiveness of applying the economic and technological dimensions of the Kingdom's Vision 2030 in achieving competitive advantage and its repercussions on the Saudi society-Hail region. The researcher employed a descriptive-analytical approach, and the sample comprised sixty faculty members at Hail University in Hail. The sample size was determined based on the size of the population of the university, the research objectives, and the availability of resources. Therefore, this sample size was considered suitable for obtaining a representative sample of faculty members in the university. A questionnaire was utilized as the instrument for the study, and it was composed of two dimensions: the economic and technological aspects. The economic aspect included the labour market, efficient labour allocation and skills improvement, support for emerging businesses, enabling entrepreneurship opportunities and attractive competitiveness. Technological aspects included administrative operations, human resources, electronic regulation and technical infrastructure. The study concluded that the arithmetic mean values of the economic dimension with its sub-dimensions were high, with a percentage ranging between (68% − 84%). This indicates that the economic dimension had an impact on the competitive advantage. The results of the study also showed that the arithmetic mean values of the technological dimension with its sub-dimensions were high, with a percentage ranging between (68% − 84%). This indicates that technology has had an impact on competitive advantage. The study findings can be used to inform policymakers and businesses in the region to make informed decisions regarding the development of the region's competitive advantage.
Water Quality Analysis of the Thorgren Naturalized Detention Basin
Authors: Aljobeh Zuhdi , Gillman Rick , Ibarra Cruz
Published: March 2023

This paper offers a case study demonstrating an integrated stormwater best management practice for nutrient removal, runoff temperature reduction, suspended solids removal, enhanced hydraulic performance and runoff storage, and improved biological integrity. The study includes data collected from the Thorgren Detention Basin in Valparaiso, Indiana, originally designed as a dry-bottom detention basin and comparison data collected from the redesigned naturalized, wet-bottom, basin. Additional information is presented about the construction, finance, operation, and performance monitoring of the basin. We found a significant stormwater quality improvement due to the implementation of the detention basin naturalization effort.
Parametric identification of the mathematical model of the micro-arc oxidation process
Authors: Pecherskaya Ekaterina , Semenov Anatoliy , Golubkov Pavel , Artamonov Dmitriy , Zhurina Angelina
Published: March 2023

An electrical equivalent circuit for the micro-arc oxidation process, taking into account the resistance of the electrolyte, the resistance of the coating of the part in the form of a parallel connection of a nonlinear active resistance and reactive capacitive resistance is presented. A mathematical model describing the behavior of the electric equivalent circuit of the micro-arc oxidation process is proposed. A procedure for determining the parameters of this model, including the construction of an oscillogram of the cell resistance change and its approximation; evaluation of resistance values and capacitance of the equivalent circuit of a galvanic cell has been developed. A method for calculating the dynamic characteristics of a model of the micro-arc oxidation process is proposed. Based on the identification results, its nonlinear Simulink model is developed. The adequacy of the model is verified by comparing the calculated and experimental voltages and currents of the galvanic cell. The maximum voltage simulation error with respect to Umax does not exceed 7%, the maximum current simulation error with respect to Imax does not exceed 10%. On the basis of experimental measurements of voltages and currents using the developed method of parametric identification, the dependences of the change in model parameters on the oxidation time are obtained. It has been established that the change in the coating resistance of a part depends on the thickness of the coating being built up. The remaining parameters of the equivalent circuit in the process of micro-arc oxidation change insignificantly.
Optimization of image reconstruction and performance evaluation for a small-animal SPECT and PET imaging
Authors: Kanno Takayuki , Onoguchi Masahisa , Shibutani Takayuki , Hiromasa Tomo , Wakabayashi Hiroshi , Kinuya Seigo
Published: March 2023

Objective: In the field of small animal imaging, Versatile emission computed tomography/computed tomography (VECTor/CT) allows for fully simultaneous acquisition with SPECT and PET tracer using a clustered multi-pinhole collimator. We determined optimal image reconstruction parameter settings and assessed performance characteristics for 99mTc and 18F imaging.
Methods: A line source phantom, a cylindrical phantom and a hot-rod phantom containing either 99mTc or 18F were used to perform quantitative analyses including the FWHM, uniformity, contrast and contrast-to-noise ratio and visual analysis. The number of subsets was set as 4, 8, 16 and 32 and the number of iterations was varied from 1 to 30. After the determination of the optimal reconstruction parameters, sensitivity and activity recovery coefficients was measured.
Results: The optimal reconstruction parameters were 32 subsets and 8 iterations for 99mTc and 32 subsets and 17 iterations for 18F. Using optimal parameters, 1.1 mm and 1.3 mm hot-rod phantoms can be distinguished for 99mTc and 18F, respectively. In addition, sensitivity was 3606 cps/MBq for 99mTc and 2052 cps/MBq for 18F. The activity recovery coefficients of 99mTc and 18F were maintained above 1.0 for more than 2 mm diameter rod and more than 3 mm diameter rod, respectively.
Conclusions: We conducted a performance evaluation with 3 phantoms while changing reconstruction parameters to determine optimal settings for 99mTc and 18F. When the optimal reconstruction parameters we found were used, it was able to visually distinguish small hot-rods diameter, compared with generally used parameter settings and then we could evaluate performance characteristics of the VECTor/CT equipped with the collimator newly designed for the size of a rat.
The application of BOPPPS combined Case-Based Learning teaching mode in clinical practice of gastroenterology for eight-year medical program students
Authors: Zhang Zhicheng , Liu Danfei , Luo Xiangyuan , Hu Dian , Wang Yufei , Xia Limin
Published: March 2023

Background To introduce the teaching mode of BOPPPS combined Case-Based Learning in the clinical practice of gastroenterology for eight-year medical program students and to explore its application effect. Methods Forty students of eight-year medical program who were interns in the gastroenterology department at Wuhan Tongji Hospital from July 2022 to November 2022 were selected and divided into 2 groups by random number table method. In the case discussion session of the clinical practice, 20 students in the experimental group received BOPPPS combined Case-Based Learning teaching method, and 20 students in the control group received the traditional teaching method. The excellent rate of knowledge mastery, assessment scores, self-directed learning ability scores, and teaching satisfaction were compared between the two groups. Results The excellent rate of knowledge mastery, assessment scores, and self-directed learning ability of the experimental group were all significantly higher than those of the control group (P < 0.05). Conclusions BOPPPS combined Case-Based Learning teaching mode is applied to the case discussion of eight-year medical program students' clinical practice in gastroenterology, which can effectively improve the knowledge mastery, theoretical performance, and self-directed learning ability of gastroenterology.
Simulation of university industry education integration mobile APP learning platform based on deep learning algorithm
Authors: Li Jianzhong , Wan Qiang
Published: March 2023

The process of modern economic development is getting faster and faster, and the overall economic development of the world has also undergone tremendous changes. The rapid development and wide use of high-tech have provided strong technical support for the industrial reform of industrial types. The new economic development model has changed the industrial structure in the previous development model, and China's economic development pattern has also made great progress relying on intelligent technology. The long-term and stable development of various industries is linked to the quality of talents in each school. The development of the new era has prompted colleges and universities to improve the level and efficiency of talent training. New advanced technologies have also provided greater space for colleges and universities to innovate teaching concepts and teaching methods. This paper takes the deep learning algorithm as the technical background of the mobile software learning platform, uses the theoretical knowledge of the algorithm to explain the implementation process and the significance of the implementation of the concept of industry education integration in colleges and universities, and carries out simulation analysis on the designed APP, providing help for the further popularization of the concept of industry education integration.
Copula Based Joint Flood Frequency Analysis: the Case of Guder River, Upper Blue Nile Basin, Ethiopia
Authors: Haile Mesfin Mamo , Khosa Rakes
Published: March 2023

The study of univariate frequency of hydrological extremes is well established in developing countries such as Ethiopia. However, the design of hydrological and hydraulic systems necessitates a thorough understanding of the flood event's characteristics, such as volumes, peaks, time of occurrence, and duration. The majority of researches use a univariate approach rather than a more realistic approach that acknowledges the multivariate nature of the underlying phenomenology. In addition to the uncertainty involved with the occurrence in both space and time, these events may frequently bear various degrees of association. As a result, the major objective of this study is to address the problem of quantifying flood events in terms of frequency of occurrence utilizing the 'Copula' based bivariate approach to analyze the joint distributions of associated flood variables with a special focus on two Guder River stations in Ethiopia. Using a 'Theory of Runs' based on a set threshold flow value, the concept was applied to flood parameters such as flood peaks and volume. Various bivariate copulas from Archimedean families were used and compared with various statistical and graphical tests. The Clayton and Gumbel-Hougaard copulas were chosen as the best fit for the flood peak and volume for stations 1 and 2, respectively. The chosen copula approach was used to determine the joint cumulative distribution, conditional distribution, and return periods required for hydrologic design. Various primary, secondary, and conditional return durations were computed and compared, and some correlations between them were established.
Correlation between Tissue Doppler-derived left ventricular systolic velocity (mitral S’) and left ventricle ejection fraction (LVEF) in sepsis and septic shock: A retrospective cohort study
Authors: Chawla Sanchit , Sato Ryota , Duggal Abhijit , Alwakeel Mahmoud , Hasegawa Daisuke , Alayan Dina , Collier Patrick , Sanfilippo Filippo , Lanspa Michael , Dugar Siddharth
Published: March 2023

Background
Tissue Doppler-derived left ventricular systolic velocity (mitral S’) has shown excellent correlation to left ventricular ejection fraction (LVEF) in non-critically patients. However, their correlation in septic patients remains poorly understood and its impact on mortality is undetermined. We investigated the relationship between mitral S’ and LVEF in a large cohort of critically-ill septic patients.
Methods
We conducted a retrospective cohort study between 01/2011 and 12/2020. All adult patients (≥ 18 years) who were admitted to the medical intensive care unit (MICU) with sepsis and septic shock that underwent a transthoracic echocardiogram (TTE) within 72 hours were included. Pearson correlation test was used to assess correlation between average MASV and LVEF. Pearson correlation was used to assess correlation between average mitral S’ and LVEF. We also assessed the association between mitral S’, LVEF and 28-day mortality
Results
2,519 patients met the inclusion criteria. The study population included 1,216 (48.3%) males with a median age of 64 (IQR: 53–73), and a median APACHE III score of 85 (IQR: 67, 108). The median septal, lateral, and average MASV were 8 cm/sec (IQR): 6.0, 10.0], 9 cm/sec (IQR: 6.0, 10.0), and 8.5 cm/sec (IQR: 6.5, 10.5) respectively. MASV noted to have moderate correlation with LVEF (r = 0.46). In multivariable logistic regression analysis, average MASV was associated with an increase in both 28-day ICU and in-hospital mortality with odds ratio (OR) 1.04 (95% CI: 1.01–1.08, p = 0.02) and OR 1.04 (95% CI: 1.01–1.07, p = 0.02) respectively.
Conclusion
Even though MASV and LVEF may be related, they are not exchangeable and were only found to have moderate correlation in this study. LVEF is U-shaped, while MASV has a linear relation with 28-day ICU mortality. An increase in average mitral S’ was associated with higher 28-day mortality.
Description of the echolocation pulses of insectivorous bats with new records for southwest Colombia
Authors: Arévalo-Cortés Johana , Tulcan-Flores John , Zurc Danny , Montenegro-Muñoz Silvia A. , Calderón-Leytón Jhon Jairo , Fernández-Gómez Ronald A.
Published: March 2023

Diversity surveys may be performed by different sampling methods. In the case of bats, the use of traditional methods such as mist nets, harp traps, and roost detection have limitations in widely covering the diversity in a landscape. Most registered species are restricted to species that forage at the undergrowth or in enclosed spaces. However, acoustic monitoring is complementary to conventional methods and can help obtain more complete bat inventories while avoiding alterations in usual foraging activities and disruption in their life cycles. This study describes the acoustic parameters (spectral and temporal variables) of the echolocation pulses of insectivorous bats to characterise acoustically different species of bats present in southwest Colombia. We recorded echolocation calls between December 2017 and May 2020 in the Andean and Pacific regions of the department of Nariño. A total of 81 sequences from free-flying bats were analysed from eight species belonging to three families: Vespertilionidae, Molossidae and Emballonuridae. Myotis riparius and Lasiurus blossevillii were registered for the first time in Nariño Department. The species M. albescens, M. keaysi, M. riparius and L. blossevillii (Vespertilionidae) had pulses of frequency modulated with a quasi-constant ending; Molossus molossus, Tadarida brasiliensis and Promops centralis (Molossidae) had pulses with constant and quasi-constant frequencies; and Saccopteryx bilineata (Emballonuridae) had pulses with quasi-constant frequencies. This study enriches the efforts to solve acoustic species classification issues of insectivorous bats in the Neotropics.
RNA- Seq analysis of Taverniera cuneifolia (Roth) Ali.
Authors: Momin Talibali , Puvar Apurvasinh , Zala Harshvardhan , Ayachit Garima , Joshi Madhvi , Nagar Padamnabhi
Published: March 2023

Aims: To unravel the potential of Taverniera cuneifoliain transcriptomics
Methods: RNA Seq experiment was conducted using NGS to understand the key metabolites and genes from Taverniera cuneifolia(Roth) Ali.
Key results: 7.29 Gb of raw data and generated 5,59,91,233 raw reads. The high-quality reads were de novo assembled by Trinity assembler followed through CD-HIT resulted into 35,590 Unigene with an average of 419 bp. The unigenes analyzed using BLAST2GO resulted in 27884 (78.35%) transcripts with blast hits, 22510 (63.25%) transcripts with mapping and 21066 (59.19%) transcripts with annotation. Functional annotation was carried out using NCBI non-redundant and Uniprot databases resulted in the identification of 21066 (59.19%) annotated transcripts and GO assigned to 24751 (69.54%) transcripts. The gene ontology result shows maximum sequences match with Biological Processes (48%) Molecular Function (27%) and Cellular components (23%). A total of 179 metabolic enriched pathways were identified which included pathways like Sesquiterpenoid and triterpenoid pathway which were involved in synthesis of important secondary metabolite Glycyrrhizin biosynthesis. Transcription factors were predicted by comparison with Plant Transcription Factor Database and 1557 transcripts belonging to 85 transcription factor families were identified.
Conclusions: This transcriptome analysis provided an important resource for future genomic studies in Taverniera cuneifolia., besides identifying functional secondary metabolites genes of Taverniera cuneifolia with Pharmacological potential for future functional genomics and metabolomic engineering of secondary metabolites form these plants towards diversified industrial applications.
Implications: The study confirms that presence of glycyrrhizin producing genes with six key genes that are backbone of sesquiterpenoid biosynthesis pathway in Taverniera cuneifolia.
Significance
Licorice (Glycyrrhiza glabra roots) is used as traditional Chinese herbal medicines in majority of formulations. Licorice is also used in Industries like food, herbal and cosmetics etc. due to its high demand in the market it is imported from foreign countries and is not available locally of superior quality (Y. Liu et al., 2015). In India, Taverniera cuneifolia has been described as a potent substitute of Licorice, it has been quoted in ancient books like Charak Samhita during the Nigandu period (Pal & Shukla, 2003) and Barda dungar ni Vanaspati ane upyog (Indraji, 1910). It has been used as an expectorant, anti-inflammatory, anti-ulcer, wound healing, blood purifier etc. Transcriptomic studies will assist in understanding the basic molecular structure, function and organization of information within the genome of Taverniera cuniefolia. This study will help us to identify the key metabolites their expressions and genes responsible for their production.
Assessment of Halon-free agents for fire safety application in aircraft propulsion system
Authors: Dinesh Akhil , Diakostefanis Michael , Sampath Suresh
Published: March 2023

Halon 1301 is an effective total flooding fire suppression agent which is widely employed in aircraft cargo and propulsion systems for emergency fire scenarios. The production of Halon 1301 was banned by the Montreal Protocol in 1994 due to its environmental impact on ozone depletion and long atmospheric lifetime. Thus, a credible alternative is required for fire safety application on-board aircrafts. This study forms a follow-up to the work published by A. Dinesh et.al [14] and M. Diakostefanis et.al [16] which studied halon-free fire suppression in aircraft cargo bay through CFD and experimental validation respectively. Due to constraints in cost and logistics of testing fire suppression in a gas turbine engine, a computer modelled fire zone of a hypothetical high-bypass turbofan engine was used to simulate and evaluate the fire suppression performance of three Halon-free agents - HFC-125, HFC-227ea and FIC-13I1. Halon 1301 was also simulated to provide baseline comparison to the alternative agents. The capacity to inert was based on the distribution of agent concentrations subjected to a heptane-based fuel fire. Simulations were conducted at ISASLS and 40,000 feet to represent the engine’s operating environment. Overall, it was found that HFC-125 and HFC-227ea satisfactorily suppressed fire at both ambient scenarios. It was found that agent density and suppression concentration significantly influenced the agent’s ability to mix with ambient air and flood the fire zone. Density of the agent combined with higher inertion concentrations also influenced formation of localised recirculation zones which influenced mixture distribution in the fire zone. The simulations enabled identification of individual changes to agent flow characteristics at different operating conditions and demonstrated the performance criteria of Halon 1301 along with the proposed alternative agents for successful fire suppression. Through this study, it was found that all the agents except FIC-13I1 passed the minimum suppression criteria making HFC-125 and HFC-227ea suitable agents for replacement of Halon 1301. The failure of FIC-13I1 was attributed to the complex design in fire zone and could be overcome by considering a higher factor of safety for this design and injecting higher mass flow rate of the agent into the fire zone. The outcome of this study proposes further work to be carried out through experimental validation of the CFD simulations which will be key to progress the technology to higher TRL and meet aviation certification requirements. Further work may also explore blended agent configurations to tailor the agent characteristics to meet suppression requirements for maintaining safety and reliability of the system.
Disability or disabilities: construction of a specific model of stereotypes
Authors: BURZOTTA Morgane , BERTOLINO Marilena
Published: March 2023

INTRODUCTION- Disability is associated with stereotypes that are detrimental in a work context and may explained disabled difficulties to find and keep a job.
OBJECTIVE- This paper’s aim is to posit and test a model of judgment about disabled people that enhanced classical two-dimensional models (Abele & Wojciszke, 2007; Fiske, Cuddy, Glick, & Xu, 2002)investigating specific stereotypes about disability.
METHODS- Workers (N= 397) had to evaluate a disabled person presented in a hypothetical vignette on 21 stereotypes generally associated with disability. The disability disclosed in the vignette variates between experimental conditions (i.e. depression, HIV, obesity, hearing problems, chronic low back pain, and dyslexia).
RESULTS- An exploratory factor analysis based on the 21 stereotypes revealed a three-dimensional model (i.e. warmth, competence, and contextual performance). When exploring differences between disabilities, depression was systematically perceived more negatively than the other disabilities tested.
CONCLUSIONS- In addition to competence and warmth dimensions, stereotypes about disabled people articulates on a third dimension: contextual performance. This specific preoccupation about disabled workers is important to consider when trying to understand recruiters’ reluctance when hiring a disabled person. Moreover, this study showed that depression is particularly discriminate even when compared to other stereotyped disabilities.
Identification and Validation of Cuproptosis-Related Predictive Risk Signatures based on renal clear cell carcinoma
Authors: Ma Zhihui , Liang Haining , Cui Rongjun , Ji Jinli , Liu Hongfeng , Liu Xiaoxue , Shen Ping , Wang Huan , Wang Xingyun , Song Zheyao , Jiang Ying
Published: March 2023

Background: Renal clear cell carcinoma is the main type of kidney cancer and its prognosis is poor. The role of cuproptosis as an emerging tumor treatment modality in renal clear cell carcinoma is still unclear. Therefore, it is urgent to discover new prognostic markers and the role of Cuproptosis in renal cancer.
Method: The source of cuproptosis-related genes was collected from the reported study from PubMed. RNA expression data and the clinical information of the corresponding patient were obtained from The Cancer Genome Atlas (TCGA) database. We randomly split the whole case into training and testing cohorts. We used three different regression analyses to confirm that lncRNAs with prognostic relevance of KIRC in the training cohort. The test cohort and the whole cohort were also included in the regression analysis to prove the accuracy of the model. eventually, a nomogram on account of clinical characteristics as well as risk scores was constructed to predict survival KIRC.
Result: 119 lncRNAs linked to overall survival were gained by univariate cox regression analysis. Furthermore, to further screen for prognosis-related lncRNAs and to optimize the signature, 119 genes were included in LASSO regression as well as multifactorial Cox regression analysis. A new prognostic predictive risk profile containing four lncRNA was produced. Kaplan-Meier (KM) curve showed that patients in the high-risk group showed poor survival in all three components. The area under the curves (AUCs) for 1 year calculated from the roc curve for the three components is 0.754, 0.698, and 0.743. 0.721 and 0. 753. Moreover, the nomogram allows the calculation of 1-, 3-, and 5-year survival rates for patients with renal clear cell carcinoma.
Conclusion: A new prognostic signature with four CRLs (MYG1-AS1, MELTF-AS1, AL161782.1, AC112220.2) have significant prognostic value for KIRC was conducted. It may provide a new therapeutic treatment for KIRC patients in the clinical.
Effect of m1A regulators on prognosis of colorectal cancer
Authors: Jin Yuqing , Liu Pu , Liu Jiayi , Wang Yu , Ren Weiyan , Tang Xuejiao , Shi Xinrui , Pan Dongchen , Tian Guo , Yang Lei
Published: March 2023

Background
Colorectal cancer (CRC) is one of the most serious public health problems. N1-methyladenosine modification appears to play a significant role in colorectal cancer development. Herein, we attempted to develop a prognostic prediction model to predict colorectal cancer prognosis using multiple m1A regulators and clinical characteristics.
Methods
The TCGA database was used to evaluate the expression of the m1A gene in CRC, and clustering analysis was carried out. The prognostic model of CRC was created using the Limma software, K-M survival analysis, and multivariate Cox regression, and it was then verified using the GEO database.
Results
We comprehensively evaluated m1A modification patterns and identified m1A subtypes used clustering analysis in CRC. Limma package was used to identify 17 differentially expressed m1A regulators in CRC patients, including 14 up-regulated regulators and 3 down-regulated regulators. K-M survival analysis identified three m1A regulators (TRMT61B, HNRNPM, and YTHDC1) associated with overall survival in CRC patients. A gene signature based on these three m1A regulators was developed using multivariate Cox regression which was efficient in predicting long-term prognosis of CRC patients. In addition, multivariate Cox regression analysis demonstrated that risk score (HR: 2.598, 95% CI: 1.226–5.506, P = 0.013) and TNM stage (HR: 1.923, 95% CI: 1.235–2.993, P = 0.004) are two independent prognostic factors. Next, we constructed a nomogram with a concordance index of 0.720 based on gene signature and TNM stage to provide a personalized overall survival prediction in CRC patients. Compared with TNM stage, the nomogram exhibited excellent performance in predicting prognosis. The AUC of 1-, 3- and 5-year OS rates of TNM stage were 0.720, 0.745 and 0.742; whereas the AUC of 1-, 3- and 5-year OS rates of nomogram were 0.721, 0.760 and 0.772 in TCGA database, respectively. Last but not least, the expression of three m1A regulators were verified by q-PCR experiment and the prognostic performance of gene signature and nomogram were validated in a cohort of GEO datasets.
Conclusion
We have constructed and verified a novel prognostic gene signature and a nomogram based on m1A regulators that might effectively promote overall survival prediction in CRC patients.
SPN-AS: A new white-box cryptographic algorithm based on AS iteration structure
Authors: Yang Ya-tao , Zhai Yu-ying , Dong Hui
Published: March 2023

The attacker in white-box model has full access to software implementation of a cryptographic algorithm and full control over its execution environment. In order to solve the issues of high storage cost and inadequate security about most current white-box cryptographic schemes, SPN-AS, a novel white-box block cipher based on AS iterative structure is proposed. This scheme utilizes the AS iterative structure to construct a lookup table with a five-layer ASASA structure, and the maximum distance separable matrix is used as a linear layer to achieve complete diffusion in a small number of rounds. Attackers can be prevented from recovering the key under black-box model. The length of nonlinear layer S and affine layer A in lookup table is 16 bits, which effectively avoids decomposition attack against the ASASA structure and makes the algorithm possess anti-key extraction security under the white-box model, while SPN-AS possesses weak white-box (32KB, 112)-space hardness to satisfy anti-code lifting security. SPN-AS has provable security and better storage cost than existing schemes, with the same anti-key extraction security and anti-code lifting security, only 128KB of memory space is required in SPN-AS, which is only 14% of SPACE-16 algorithm and 33% of Yoroi-16 algorithm.
Investigation on the influence of crosslinking and swelling properties of modified silica-chitosan films for the controlled removal of Alexandrium minutum
Authors: Iqbal Anwar , Ibrahim Nur Hanisah , Mohammad-Noor Normawaty , Razali Roziawati Mohd , Yanto Dede Heri Yuli , Jasni Normawati , Wilson Lee D.
Published: March 2023

Harmful algal blooms (HABs) are natural phenomenon that threatens public health, tourism, fisheries and ecosystems. Silica in its natural form is unable to mitigate HABs effectively and frequently modified with chitosan. In this study, the influence of crosslinking and swelling properties of rice husk ash silica/chitosan film reinforced with (3-glycidyloxypropyl) trimethoxysilane (GPTEOS) and glycerol (Gly) in capturing HABs cell, Alexandrium minutum was thoroughly investigated. The XRD analysis indicated that crosslinking had caused part of the chitosan’s crystalline network to become amorphous. The FTIR analysis showed that the chitosan, silica, glycerol and GPTEOS were crosslinked via a condensation reaction. The crosslinking was higher in the film containing GPTEOS (CHT/SiO2/GPTEOS) due to the condensation reaction between the GPTEOS epoxy group and the amine of chitosan in addition to the condensation of silanol and hydroxyl group of chitosan. As a result, the swelling of CHT/SiO2/GPTEOS was lower compared to Gly-containing film (CHT/SiO2/Gly). The RE value was 26.57 ± 10.81% using CHT/SiO2/Gly and 50.06 ± 11.90% using CHT/SiO2/GPTEOS. Based on the swelling and the RE trends, it is concluded that the initially trapped algae could have been released back into the environment when the films swelled. This study shows that crosslinking is important trapping the algae. The SEM and digital microscopic images of the used films revealed the presence of algae cells on the surface of the films. The films could be easily separated from the algae culture without sedimentation. The films also showed good biodegradability as all the films were fully degraded within 30 days of burial.
Radiation Dose from Cassava Samples from a Coal Mining Area of Enugu, Enugu State, Nigeria
Authors: Amakom Chijioke M. , Orji Chikwendu E. , Okeoma Kelechukwu B.
Published: March 2023

Cassava is one of the most staple food for the Nigerian population and is consumed in large quantity daily. Food intake is one of the routes of radiological contamination to man. Cassava samples from an old coal mining area of Enugu, Enugu State, Nigeria were analyzed using gamma ray spectroscopic method. The mean activity concentrations for the radionuclides 40K, 226Ra and 232Th respectively ranged from 193.68-300.92 Bq/kg, 23.03-37.24 Bq/kg and 135.33-158.43 for camp 1, camp 2 and Pottery areas respectively. The total mean annual effective dose due to the three observed radionuclides was 2.03 mSv/yr, which was higher than the recommended value of 1 mSv/yr. The cassava samples from the area under study showed high radiotoxicity levels.
Compound glycyrrhizin tablets have induced Chronic cardiotoxicity in Sprague-Dawley rats by activating oxidative stress through the Keap1/Nrf2/HO-1 signaling pathway
Authors: Jiang Zhangyu , Ye Ran , Zhang Song , Cai Weibin , Zhang Miao , Yang Dongying , Cai Qiang , Zhang Rong , yang Lei , Xu Qin
Published: March 2023

Introduction: The purpose of this study is to look into the mechanism of chronic cardiotoxicity induced by a long-term use of compound glycyrrhizin tablets (CGT).
Materials and Methods: CGT was orally administered to SD rats. Then, the relative heart weight was measured, and the pathological changes of heart tissue were observed. Physiological indices were determined, including alanine aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), brain natriuretic peptide (BNP), superoxide dismutase (SOD), and malondialdehyde (MDA). The levels of Na+-K+-ATPase and Ca2+-Mg2+-ATPasewere detected. The expressions of M-CK, BNP, Keap1, Nrf2, and HO-1 were assessed.
Results: After several days of CGT treatment, the rats showed heavier relative heart weight and were found to have pathological changes in heart tissues. Moreover, the serum levels of LDH, AST, CK, CK-MB, and BNP were increased in the dose groups. The expression of M-CK was elevated in the middle-dose and high-dose groups, while the level of BNP showed an upward trend. The level of SOD was decreased, and the content of MDA was increased. The expressions of cytoplasma-Keap1 were increased in the middle-dose and high-dose groups, and the expression of nucleus-Nrf2 was reduced in all CGT groups, and the expression of HO-1 was decreased in the high-dose group.
Conclusions: According to these results, we suggest that long-term and high-dose CGT administration is up-regulating Keap1, down-regulating nuclear-Nrf2 and HO-1, resulting in elevating the level of ROS and inducing cardiotoxicity in SD rats by activating the oxidative stress pathway.
Is there a relationship between the helical pattern of hypertrophy and atrial fibrillation in patients with hypertrophic cardiomyopathy?
Authors: Celik Ibrahim Etem , Bozkurt Ugur , Yigit Hasan , Yarlioglu Mikail , Duran Mustafa , Murat Sani Namik
Published: March 2023

Purpose: Atrial fibrillation (AF) is commonly seen in patients with hypertrophic cardiomyopathy (HCM) and is associated with left atrial enlargement, fibrosis and diastolic dysfunction. Cardiac magnetic resonance (CMR) imaging provides important information about the geometric pattern of hypertrophy that may related to worse clinical outcomes such as arrhythmic events. The purpose of this study was to determine whether helical pattern is associated with increased risk for AF and diastolic dysfunction in patients with HCM.
Methods: A total of 50 consecutive patients with HCM referred for CMR imaging were enrolled into the study. The helical pattern was evaluated by measurement of the maximal left ventricle wall thickness (LVWT) for each of the 17 classical LV segments.
Results: A spiral pattern was observed in 20 patients (40%). We found significantly higher incidence of AF in patients who detected helical distribution than in those who did not (40% vs. 10%, p = 0.012). Left atrial volume index (LAVI) was also higher in patients with helical pattern compared to non-helical pattern (32.5 mL/m2 ± 16.9 vs. 23.7 mL/m2 ± 5.8; p < 0.001).
Conclusion: Our study suggests that presence of helical pattern is associated with significantly increased risk of development AF and LAVI in HCM patients.
Numerical Analysis of Transient Non-linear Heat Transfer by Spectral Method Based on POD Reduced-order Extrapolation Algorithm
Authors: Ba Zhenggang , Wang Ye
Published: March 2023

In order to meet the requirements of high accuracy and fast algorithm for numerical heat transfer simulation, a POD reduced-order extrapolation algorithm based on the iterative format of the classical central difference Gakerkin spectral method is proposed for solving two-dimensional transient heat conduction problems. Using the calculation results of classical central difference Gakerkin spectral method as sample data constructs POD reduced-order spectral method model; A study on numerical algorithm characteristics of flow and heat transfer using partial differential equation as mathematical model, and gives the error estimate; Finally, taking different time steps as parameters to conduct experimental simulation in turn. The results show that: the spectral method based on POD reduced-order extrapolation method is at least 253 times faster than the central difference Gakerkin spectral method, and gradually decreases with the interval of variable parameters. The calculation speed of POD reduced-order model and the calculation speed of central difference are both reduced. However, the average relative error between the temperature field reconstructed by POD reduced dimension model and the central difference result is smaller and the calculation accuracy is higher, the maximum value is not more than 0.11%.The average computational efficiency is 458 times higher than that of the traditional central difference Gakerkin spectral method.
A Smart City Air Pollution Prediction System Using Machine Learning
Authors: Mathur Mitali , Tawar Aman , Verma Indu
Published: March 2023

Air pollution is one of the main cause of infections to human health. According to World Health Organization, 15 million people are at health risk due to air pollution every year and numbers are increasing every day because of excess use of coal and petroleum which has increased the interest in air pollution and its impacts among the scientific community. We are going to create and a model that might help us in predicting air quality. There we have a large database provided for the analysis and modelling. On the basis of this we will study all the important features like which concentration of benzene, NO2, CO2 etc. in the air and using all these categories we will determine the air quality. The tools used in this are Machine Learning Algorithms, Python, Feature Engineering, Pandas, NumPy, Seaborn, Flask, HTML, CSS etc.
This model can be used by several government organizations and can help them in making the right decisions related to approval or rejection of any industrial project to control pollution level of our country by using Machine Learning algorithms.