bluuebunny/crossref_metadata_2025 huggingface dataset:
IntelliMedChain: Knowledge Driven and Blockchain Powered Data Sharing Framework for Smart Healthcare
Authors: Kshirsagar Meghana , Vaidya Gauri Vaidya , Yao Yao , Kasar Smita , Conor Ryan
Published: May 2022

The healthcare profile of an individual is scattered across multiple
data sources which can be difficult to access in a timely fashion.
Furthermore, while the need to secure an individual’s personal health
record is of paramount importance to prevent compromises such as
cyber-attacks, it is important to be able to be able to seamlessly and
quickly share information across healthcare providers to further enable
precision and personalized health care. We present IntelliMedChain, a
blockchain-powered knowledge-driven data sharing framework that gives
patients complete control of their medical data and which can extract
rich information hidden in the medical records using knowledge graphs
(KGs). By incorporating both blockchain and KGs, we can provide a
platform for a secure data sharing amongst stakeholders by maintaining
data privacy and integrity through data authentication and robust data
integration. We conduct a pilot study of the IntelliMedChain network
using Ethereum blockchain technology to share knowledge across
stakeholders. We show how it mitigates the issues around scalability by
efficiently managing large-scale data and interoperability through
seamless adoption of data regulations, as prescribed by various
regulatory bodies for efficient governance.
Analysis of micrognathia with obstructive sleep apnea syndrome improved by a combination of Le Fort I with horseshoe osteotomies, mandibular distraction osteogenesis, and genioplasty
Authors: Koshinuma Shinya , Fujii Takafumi , Okamura Takeshi , Asada Yasuyuki , Machida Yoshisato , Yamamoto Gaku
Published: May 2022

Background: The relationship between microgenia and obstructive sleep
apnea syndrome is well known. Patients: 27-year-old woman. She underwent
a combination of Le Fort I with horseshoe osteotomies and mandibular
distraction osteogenesis and genioplasty. Results and Conclusions: She
was satisfied with the aesthetics of her face, with an AHI of 7.8/h.
Asymptotic analysis of spectral problems in thick junctions with the branched fractal structure
Authors: Mel'nyk Taras
Published: May 2022

A spectral problem is considered in a domain
$\Omega_{\varepsilon}$ that is the
union of a domain $\Omega_{0}$ and a lot of thin
trees situated $\varepsilon$-periodically along some
manifold on the boundary of $\Omega_{0}.$ The trees
have finite number of branching levels. The perturbed Robin boundary
condition
$\partial_{\nu}u^{\varepsilon}
+ \varepsilon^{\alpha_i}
k_{i,m}u^{\varepsilon} = 0$ is given on the
$i$th branching layer;
$\{\alpha_i\}$ are
real parameters. The asymptotic analysis of this problem is made as
$\varepsilon\to0,$ i.e., when the number
of the thin trees infinitely increases and their thickness vanishes. In
particular, the Hausdorff convergence of the spectrum to the spectrum of
the corresponding nonstandard homogenized spectral problem is proved,
the leading terms of asymptotics are constructed, and the corresponding
asymptotic estimates are justified for the eigenvalues and
eigenfunctions.
Early postoperative results analysis of standard and mini-incision posterolateral approach in total hip arthroplasty
Authors: Baljozovic Andreja , Mirkovic Milan , Aleksic Marko , Jevtic Aleksandar , Bascarevic Zoran
Published: May 2022

Background/Aim. Total hip arthroplasty is the replacement of the hip joint with an artificial one. Standard surgical procedures involve a long skin incision and extensive dissection of healthy tissue. Mini-incision surgery is a modification of standard operative approaches. In addition to a significantly smaller skin incision, the main difference is based on much less damage to soft tissues, especially the muscles that move the hip. The aim of this study was to compare the early results of the mini-incision and a standard approach in total hip arthroplasty and to determine the advantages and disadvantages of the mini-incision surgical technique. Methods. A retrospective study analyzed data based on 63 patients who underwent total hip arthroplasty with a mini-incision and standard approach at the Institute of Orthopaedic Surgery ?Banjica?, Belgrade from 2004 to 2010. All the patients suffered from primary coxarthrosis. All operations were carried out by the same surgical team. All patients were clinically evaluated before and after the surgery using the Harris Hip Score (HHS). Results. The group of patients operated on with the mini-incision approach included 32 patients, while 31 patients made up the group of patients operated on with the standard approach. Comparing these groups did not reveal a statistically significant difference in age, body mass index, surgery duration, and HHS before the surgery. A statistically significant difference was determined by comparing intraoperative blood loss, the amount of drainage fluid after the surgery, and the HHS after the surgery. Conclusion. The mini-incision posterolateral approach, compared to the standard approach, apart from an esthetically more acceptable scar, achieves significantly less intraoperative blood loss and better hip function with almost the same risk of complications.
Heavy Metal Contamination of Otofure Dumpsite Environment near Benin City Edo, Nigeria
Authors: IT Aighewi
Published: May 2022

This study characteriz ed some indices of heavy metals in the soils of Otofure waste dumpsite environment near Benin City, Edo State in Southern Nigeria, in order to ascertain the level of heavy metal contamination of one of the several sites receiving municipal solid wastes dai ly. Six samples were collected at the dumpsite (DS) and the adjoining upland positions (US). The samples were air - dried, crushed and sieved through a 2mm sieve and pre - treated using standard methods before determining the h eavy metal concentrations in Atomic Absorption Spectrophotometer (Bulk Scientific 210 VGP) according to the method of the Association of Analytical Chemists. Various pollution indexes were computed using the analytical data obtained. The computed Enrichment factor (EF) showed that Mn. Fe, and cu had no enrichment at the top and subsurface of the dumpsite. However, there was a significant Zn enrichment and enrichment with Ni and V at the topsoil; and Extreme enrichment with Cr, Cd, and lead of the soil at the dumpsite. Also, the soil Co ntamination factor (CF) indicated a moderate contamination of iron (Fe), manganese (Mn) and copper (Cu), Very High contamination of zinc (Zn), chromium (Cr), cadmium (Cd), lead (Pb), nickel (Ni) and vanadium (V). Pollution Load Index (PLI) showed that Otof ure dumpsite is heavily polluted (PLI > 1) by heavy metals in general. Geoaccumulation Index (Igeo) showed that soils of Otofure dumpsite were unpolluted to moderately polluted for manganese (Mn) and copper (Cu), heavily polluted for zinc (Zn), Heavily to Extremely polluted for chromium (Cr), cadmium (Cd), lead (Pb), and nickel (Ni), and Extremely polluted for chromium (Cr), cadmium (Cd), lead (Pb) and vanadium (V). The potential ecological risk index (PERI) showed slight pollution for manganese (Mn), zinc (Zn) and copper (Cu), a very strong pollution for chromium (Cr), and an extremely strong pollution for lead (Pb), nickel (Ni) and cadmium (Cd). The risk index (RI) for Otofure dumpsite indicated a very strong risk or level D pollution for the higher elevat ion around the Otofure dumpsite environment that could pose human health risks if crops from that environment is ingested. This result thus suggest the need for a gradual shift from surface municipal waste dumping of solid wastes to well - engineered and man aged recycling/sanitary landfill in Edo State and Nigeria in order to prevent heavy metal pollution of lands and possibly groundwater where shallow aquifers exist.
Quality Management, Production Process, Innovation and Productivity
Authors: PS Sellero
Published: May 2022

This paper aims to analyse quality management systems, production process, innovation and productivity of manufacturing firms. In order to obtain that, we have taken into account aspects such as product standardization, the use of quality management systems, the complexity of the production system and some con siderations on technological innovation.
Assessment of Steel Slag as a Persulfate Activator for Treatment of Landfill Leachate
Authors: AM Soubh
Published: May 2022

In this research, the performance of steel slag (SS) as an activator of persulfate (PS) for the removal the chemical oxygen demand (COD) of raw leachate landfill was studied. The experiments were conducted in a batch reactor. The SS was obtained from the Esfahan Steel Company, Iran. X - ray diffraction (XRD) and field emission scanning electron microscope (FE - SEM) and energy dispersive spectroscopy (EDS) analysis were used to investigate the characteristics of the SS. The effects of SS dosage (0 - 5 g L - 1 ), PS/COD ratio (1 - 5), and reaction time (0 - 180 min) on the removal of leachate landfill. The Maximum removal efficiencies at optimize operational conditions (SS dosage 3 g L - 1 , PS/COD ratio: 3 and reaction time: 45 min) was 83%. The addition of SS (3 g L - 1 ) led to more than six and a halftimes increase in degradation rate constants of COD.
Comprehensive Model to Predict the Yield of the Pyrolysis Products of Kraft Lignin Based on Lumped Approach
Authors: Elshokary Sherif
Published: May 2022

This work presents a comprehensive model based on the lumping approach to quantit ively predict the products of the pyrolysis of kraft lignin. The yield of the primary pyrolysis products - biochar, bio - oil, and biogas - that are produced from the thermal decomposition of the lignin network are estimated. Different pyrolysis conditions and r aw material characteristics are considered . The impacts of the particle size of the raw material, pyrolysis heating rate, and reaction residence time are taken into the investigation. The comparison of the predicted results using the developed model agains t the experimental data showed the high capability of the presented models to predict the biochar, bio - oil, and biogas yield under the examined conditions.
New Approaches in Drinking Water and Wastewater Treatment Coagulation System: A Mini - Review
Authors: S Cheshmekhezr
Published: May 2022

Turbidity and natural organic matters (NOMs) cause change in odor, color, and taste of drinking water as well as increasing the concern of bacterial growth in water and wastewater. This article aims to review the coagulation process and to introduce the po tential approaches that can help the water and wastewater authorities to come up with the best coagulant selection. The coagulation is a physicochemical process that is used in the conventional treatment process to reduce turbidity, suspended particles, an d NOMs. Aluminum sulfate (alum) and ferric chloride are the most common coagulants that are used as chemical coagulants. However, there are some health concerns associated with the residual sludge and extra dose of chemical coagulants in treated water and wastewater such as increasing risk of Alzheimer and cancer. Natural Coagulants could be an alternative to reduce the dose of chemical coagulants and residual sludge and consequently reducing the health risks. Natural coagulants are effective in reducing pa rticles, alongside the chemical coagulants or as a stand - alone process. The multidimensional nature of choosing the best process in water and wastewater treatment makes it difficult to select the best coagulant with the minimum health risk. Therefore, we n eed a systematic framework for modeling the coagulation process and selecting cost - efficient coagulant(s) to reduce health risk. Mathematical modeling and health risk assessment are two of the approaches that can be used to select the optimum range and tra ck the residual and found to be helpful for the health risk reduction.
DETERMINAN PENGAMBILAN KEPUTUSAN INVESTASI BERDASARKAN NORMA SUBJEKTIF, KONTROL PERILAKU, DAN PERILAKU HEURISTIK
Authors: Wirawan Rosadi , Mildawati Titik , Suryono Bambang
Published: May 2022

This study aims to obtain empirical evidence of the influence of Subjective Norms, Behavioral Control, and Heuristic Behavior on Investment Decisions. We used 54 respondents of individual investors who are just learning and or have already transacted on the Indonesia Stock Exchange (BEI) as a sample. By using multiple regression analysis, we found that the subjective norm has an effect on investment decisions. This means that the higher the influence of individual external environmental pressures, namely observers, friends, mass media, and investment management, the greater the individual's ability to make investment decisions. Behavioral Control has an effect on Investment Decisions. This means an understanding of the simplicity or complexity of taking action based on past experience and the obstacles that may be faced when taking action, affecting individuals in making investments. Heuristic behavior affects investment decision making. This means that the level of confidence and experience possessed by individuals and other known people will influence individuals in making accurate investments.
Agilität und Achtsamkeit gehen Hand in Hand. Eine neue Perspektive auf agiles Projektmanagement mit einem achtsamen Mindset
Authors: Weifenbach Martina
Published: May 2022

In Zeiten von Transformation, Digitalisierung und einer zunehmenden Veränderungsgeschwindigkeit, ist es in der modernen Arbeitswelt unabdingbar, agile Ansätze anzuwenden. Agilität beschreibt die Fähigkeit eines Unternehmens bzw. eines Teams, sich schnell zu verändern oder anzupassen, um auf Veränderungen zu reagieren. Mitarbeiter und Mitarbeiterinnen werden im Rahmen eines agilen Arbeitsumfeldes dazu befähigt, mit auftretenden Problemen und Veränderungen effizient umzugehen und experimentierfreudig an diese Aufgaben heranzutreten. Achtsamkeit und Achtsamkeitsmethoden können dabei helfen, eine flexible sowie offene Denkweise zu trainieren. Die individuelle Praxis und die mentalen Trainings bringen diverse Vorteile für die Arbeit in Projektteams mit sich und haben nachweislich positive Effekte auf Kreativität, Resilienz, Empathie und Innovationskraft. In diesem Artikel wird beleuchtet, was hinter Achtsamkeit steckt und wie sie agile Unternehmen unterstützen kann. Anhand von praktischen Beispielen wird verdeutlicht, wie die Integration gelingen kann und somit ein agiles Arbeitsumfeld geschaffen wird.
Driving Digital – … but Human is Key (1). Ein Plädoyer für ein „Anthropozentrisches (IT- und) Projektmanagement“ im Digitalen Zeitalter
Authors: Pietzner Matthias
Published: May 2022

Kaum ein Tag vergeht, an dem nicht irgendjemand fragt, wie das mit der „Digitalisierung“ denn funktioniert, wie es weitergehen soll, wer wie, wo und wann davon betroffen sein oder darunter leiden wird – und was das alles mit mir ganz persönlich, mit meinem Job und meinem Umfeld zu tun hat! Und Sie? Haben Sie Ihren Standpunkt in diesen Fragen schon gefunden? Und falls ja, kennen Sie Ihren Kompass und Ihre Leitplanken für Ihren persönlichen Weg in das Digitale Zeitalter? Falls ja gratuliere ich Ihnen von Herzen; das macht gelassen und motiviert und ermöglicht Leistung! Falls nein könnten Ihnen dieser Beitrag in der PROJEKTMANAGEMENT AKTUELL vielleicht helfen, Antworten und Orientierung zu finden; durch Strukturierung von Themen und Gedanken, durch Zustimmung oder Aha-Erlebnisse genauso wie vielleicht durch bewussten Widerspruch oder gar Ablehnung. Seien Sie offen und fühlen Sie sich eingeladen, einem leider oft „unterbelichteten“ gleichwohl jedoch essenziellen Themen-„Komplex“ (im doppelten Sinne des Wortes) der Digitalen Transformation nachzuspüren.
Die Auswahl der passenden Software-Einführungsstrategie. Schritt für Schritt oder gleich mit großem Knall?
Authors: Artaza Francisco Josué , Dorl Maik
Published: May 2022

Wie gelingt die Einführung komplexer Unternehmenssoftware? Wer Einflussfaktoren nicht kennt oder falsch gewichtet, wählt leicht die falsche Einführungsstrategie. Mit Struktur und passender Strategie senken Sie Kosten und Risiko und steigern die Akzeptanz. Der Erfolg einer Softwareeinführung steht und fällt mit der Auswahl der Rollout-Strategie. Neben rein iterativen Modellen und dem Big-Bang-Ansatz stehen eine Reihe kombinierter Einführungsstrategien zur Auswahl. Eine Softwareimplementierung ist ein komplexes Projekt, das nach einer strukturierten Vorgehensweisen verlangt. Jede Strategie kann bei bestimmten Rahmenbedingungen zum Scheitern des Einführungsprojekts führen. Damit sich Kundenunternehmen und Anwenderberater gemeinsam für die richtige Strategie entscheiden, müssen sie die Einflussfaktoren für die Auswahl der optimalen Strategie zu identifizieren und zu steuern wissen. Den Weg zur geeigneten Rollout-Strategie weist ein eigens dafür entwickeltes Expertentool, das sämtliche Einflussfaktoren berücksichtig und individuell gewichtet.
Philosophical ideas in the culture of Kievan Rus (historiographic review)
Authors: Potapova Lydia
Published: May 2022

The purpose of the article is to reveal the history of the study of philosophical ideas in the culture of Kievan Rus. The research methodology basing on historical, logical, analytical and general methodological approaches. The novelty of the study. The question about the existence of philosophical ideas in the culture of Kievan Rus and the historiographical basis of their existing forms is the essence of the presented article. Conclusions. Investigating this problem, historiographicaland methodological problems were revealed: - the problem of periodization of philosophical studies of Kievan Rus; - the existence of the philosophy of Kievan Rus; - ancient written sources, which interprets as philosophical.
Рolicy of ukrainian greek catholic church during the nazi occupation (1939-1944)
Authors: Havrylov Vladyslav
Published: May 2022

The aim of the research. The article analyzes the policy of the Greek Catholic Church on the territory of Ukraine during the Second World War. Particular attention is paid to the Western Ukrainian lands, the features of the relationship of the Ukrainian Greek Catholic Church with the Nazi administration, the leadership of the Gestapo and the Wehrmacht in the occupied territory are characterized.The aim of the work is to analyze theactivities of representatives of Greek Catholics during the Nazi occupation. The relevance of the study The relevance of the study is dictated by the absence of one general work on Greek Catholics in Ukraine during the Second World War, as well as by the need for a comparative analysis of the available works that were published in Soviet and modern Ukrainian historiography on the history of the UGCC during World War II. The method of work is based on the analysis of historical documents. Conclusions. 1939-1946 for the UGCC were marked by the struggle for survival under the pressure of Soviet, Nazi and again Soviet power.
Reflection of the confrontation between Yanku Flondor and Ion Nistor on the pages of the newspaper “Bucovina” in 1919
Authors: Piddubny Igor
Published: May 2022

The incorporation of Bukovina into the Kingdom of Romania set the political leaders of the Romanians of Bukovina the task not only of rebuilding the region after World War, but also of finding consensus in their actions aimed at creating a new country. The desire to preserve the special features and inherent institutions of the region from the Austrian era gave rise to confrontation between Yanku Flondor and Ion Nistor which was reflected in the publications of the Bukovina press. The aim. The aim of the article is to introduce into scientific circulation information on the confrontation between two Romanian political groups in Bukovina and its coverage in the Bukovina press. Research methods. In the publication used a synchronous approach and special historical methods. In particular, we used to study the situation comparative, problem-chronological methods, synchronous. the latter allows us to trace the sequence in the context of political changes in Bukovina, the evolution of the opposition's views, its search for ways to influence the population of the region. the application of the synchronous method makes it possible to establish and monitor the reaction of the opposition and pro-government to the actions of the opposite party. The scientific novelty. The scientific novelty of this article is to cover for the first time in Ukrainian historiography the confrontation between two representatives of the Romanian political camp in Bukovina and its reflection in the publication of the opposition group of Yanku Flondor to the government group. Conclusions. In general, the use of the Bucovina newspaper in the political life of the region should be considered a manifestation of the activities of a group of politicians who considered it their task to preserve the status quo of Bukovina as part of the Kingdom of Romania. In their activities, they used the norms and techniques known since the development of the national movement in the late nineteenth – early twentieth century. However, the forms of protest did not achieve the desired result in the new conditions, removing the opposition from the opportunity to act also by parliamentary methods.
Influence of Josephian metric on the situation in the Duchy of Bukovina (on the base of „Index of all areas in the Kingdom of Galicia and Lodomeria, as well as the Grand Duchy of Krakow and the Duchy of Bukovina”)
Authors: Sliusar Oleg
Published: May 2022

The article analyzes the historical background, the process of introduction and consequences of the adoption of the Josephine Metrics, the successor of Maria Theresa, Emperor Joseph II, and its impact on settlement of different ethnic groups, industrial development and economic prospects of the new lands of the Austrian Empire and Bukovina in particular in first half of the XIX century. The analysis of this issue led to the use of the following research methods, among which the etymological analysis made it possible to study the names of toponyms in Bukovina; The method of theoretical analysis in combination with practical calculations made it possible to establish the number of new settlements of ethnic groups living in Bukovina at that time, as well as a comparative analysis of Theresian and Josephine metrics and their individual components. Scientific novelty. The influence of the Josephine metric on the lands of Galicia and Bukovina, in particular, was analyzed for the first time. Conclusions. The analysis clearly shows the positive impact of the Josephine metric on the development of the newly annexed lands of the Austrian Empire in the late XVIII - first half of the XIX century.
The rites and beliefs of the romanians in Bukovina D. Dan “Folk beliefs of bukovyna”
Authors: Moysey Antoniy , Moisey Arcadiy
Published: May 2022

This study is aimed at analyzing the work of Dimitri Dan “Folk beliefs of the Bukovinians”, which is published in issue 21 of the “Letter of the Bukovinian Paper” during 1894–1895. Dan's research issues are little known in Ukraine, due to the lack of translations and publications, which are not easy to find in Ukrainian historical and ethnological libraries. The aim of the article is a comprehensive study of the rites and beliefs of the Romanians in Bukovina, using the work of D. Dan “Folk beliefs of Bukovina”: maternity, family, funeral rites, folk medicine, occasional customs and rites and more. The research methodology is based on analysis, historical approach and translation from Romanian. Conclusions. The proposed article analyzes the researcher's records in the field of family rituals (girls' participation in dances, the role of unborn water, the process of engagement, wedding, wedding, birth, protection, baptism), funeral rites, folk medicine, animal protection and more. The study includes also translations from Romanian of the original beliefs and texts of the description of the rites, which are associated with folk medicine. The novelty of presented texts from D. Dan's work is also based on the cites of the not published manuscript. The presented study helps to create a certain knowledge about the worldview of a man of that time and the processes of its evolution. The article complements the ethnographic data collected in Bukovina by other scholars. This research is also valuable because it was written by a scholar, who lived in that environment for many years and knew perfectly the customs and rituals of the Romanians.
Student government. European experience
Authors: Semenenko Svitlana , Tymofijchuk Inha , Slobodyan Ksenia , Kovpak Alona
Published: May 2022

In higher educational institutions and their structural divisions, there is student self-government, which is an integral part of the public self-government of the respective educational institutions. Student self-government allows students to be a direct participant management of a higher educational institution and solve issues of education and life, protection of the rights and interests of students. Student self-government unites all students and ensures the protection of the rights and interests of students and their participation in the management of a higher educational institution. Main part. In their activities, student bodies self-governments are guided by the legislation, the charter of the university and the regulation on student self-government of the university. Student self-government bodies operate on the principles of: voluntariness, collegiality, openness; 2) election and accountability of student self-government bodies; 3) equality of the right of students (cadets) to participate in student government; 4) independence from the influence of political parties and religious organizations (to Roma higher spiritual educational institutions). Student government starts at the student group level,flow, course, hostel, at the level of all departments where student life is seething. Student bodies self-government may have different forms (parliament, senate, starost, student administration, student deans, student councils, etc.). The experience of European colleagues and the construction of a European student community are interesting. self-government. Findings. Student self-government is based on the principles of equal rights for students, open election. And these principles are the same for all institutions of higher education. But interesting experience foreign universities, which must be studied and implemented partially within the walls of our university.
Аpproaches to the medical and social rehabilitation for children with organic lesions of the nervous system: history and current trends
Authors: Anistratenko Antonina
Published: May 2022

Preschool children with organic lesions of the nervous system need a comprehensive approach to medical and social rehabilitation. These pathologies (organic lesions of the organs of hearing, vision, vestibular and speech apparatus) are quite common among children nowadays. The process of speech formation and social behavior of such patients is complex in structural and functional organization. The purpose of the article is to investigate the history and current state of social and medical rehabilitation for sensory and other CNS defects. The novelty of the reserch. The problem of forming life competence in children with special needs from an early age remains undeveloped. Research methods are based on historical and comparative-analytical principles. Conclusions. Thus, considering various aspects of rehabilitation care for early preschool children with CNS defects and speech disorders, it was possible to determine the paramount importance of speech development in rehabilitation work with early preschool children, because successes in learning Ukrainian in this sensitive period, or their absence will significantly affect all aspects of further medical and social rehabilitation.
Pre-scientific period of chemistry development. Before stating the question
Authors: Gerush Igor , Moysey Antoniy
Published: May 2022

The purpose of article is to study the availability of historiographical and source studies opportunities for didactic use of the topic of the pre-scientific period of chemistry, bearing in mind both the natural sciences and the humanities. The methodological basis was the study of historiography and the source base of the topic, especially the alchemical period of development of chemical knowledge. Conclusions. The availability of the material in the pre-scientific period of development of chemistry as a research spere, didactic significance in both scientific and chemical and humanitarian aspects allows the creation of a study subject for medical students. This study subject brings students to understanding, how to develop theoretical and practical knowledge in the field of chemist research and its impact on medical science in the historical aspect. It will ensure the acquisition of the main essence from the stages of formation of chemistry as a science and dialectic of its development, the continuous connection with the manufacture of drugs. Students of the course will learn the evolution and patterns of development of chemical knowledge. In addition, the study subject should contribute to the understanding of the humanitarian component of the alchemical stage in the development of chemistry and philosophy, anthropology and culture.
History of adrenal discovery
Authors: Savchuk Tatiana , Kovpak Alona , Semenenko Natalia
Published: May 2022

The names of the majority neurotransmitters are little known to the average citizen. But the mention of adrenaline immediately generates a storm of associations. Someone's head will have a profile of Jason Statham from film of the same name. The purpose of the article. The adrenaline rushed a symbol of something risky and attractive in its own way, but what is adrenaline from the point of view of a neurophysiologist - the goal proposed article. A number of studies have shown that y athletes during training and competitive loads increases the activity of sympatho-adrenal and hypothalamic pituitary-adrenal systems. In this case there is an activation of physical activity mechanisms of general adaptation, which leads to changes in hormonal spectrum, which provides mobilization as energy and plastic reserves of the body, as well as its restoration. One of the groups of stress hormones produced by the cerebral layer of the adrenal glands and called catecholamines. This group includes hormones adrenaline and norepinephrine. Both hormones are synthesized fromamino acids of tyrosine under the influence of nerve impulses. The main hormone of this group is adrenaline. We set for the aim is to study the historical stages that preceded the discovery adrenal hormones, using comparative and historical methods. Relevance of research. In 1894 George Oliver and Edward Schaefer demonstrated vasoconstrictor (vasoconstrictor) and pressor effect of extraction from the adrenal glands. An important role in study of the properties of adrenaline played a role Leipzig surgeon Heinrich Brown, about the possibility use of adrenaline under local anesthesia. So adrenaline, widely used in anesthesiology, which remains relevant to this day. Conclusions. Study of historical information about the discovery hormones form a holistic view and expand knowledge in the field physiology and pathophysiology of the endocrine system.
The use of interactive teaching methods in the study of physiology by medical university students majoring in medical psychology
Authors: Savchuk Tatiana
Published: May 2022

Introduction. The future profession of medical psychologists requires a high level of training and is associated with a high responsibility for the lives and health of patients. An important factor in improving the quality of training is the rational organization of the educational process, which contributes to an effective learning process, the acquisition of professional skills. It is possible to educate a real doctor, medical psychologist, specialist in one's field only by introducing a strategy of critical thinking development into the educational process. The goal of this strategy is to "awaken consciousness" as the student becomes aware of the realities around him and seeks solutions. Main part. The introduction of interactive learning methods is in line with the concept of personality-oriented learning and is inextricably linked to the use of active and interactive learning methods, such as brainstorming. The introduction of the method of "brainstorming" in teaching physiology to students of Bukovina State Medical University has demonstrated the creation of comfortable learning conditions in which students feel their success, their intellectual ability, which makes the learning process more productive. Conclusion. The introduction of interactive teaching methods: lectures, practical and seminar classes is a requirement of a modern approach to teaching. Such methods significantly improve the assimilation of the material and form the basis of clinical thinking in students in the first year of medical university.
BRAIN INJURY IN PRETERM INFANTS - PATIENTS OF THE DEPARTMENT OF INTENSIVE THERAPY OF NEWBORN
Authors: Yablon O. , Bondarenko T. , Vlasenko V. , Bedriy N. , Shovkoplyas N.
Published: May 2022

Introduction. Advances in reproductive and perinatal technologies have led not only to an increase in the number of premature babies and an increase in survival rates, but also to an increase in the incidence of complications. Nervous system diseases play a leading role in the structure of pathologies of premature infants. Early onset of extrauterine life contributes to the disruption of physiological processes of brain maturation, increasing the risk of neurological complications.Objective. To establish the frequency and structure of brain damage in premature infants-patients of the intensive care unit. Materials and methods. The mortality and morbidity rates of premature infants-patients of the intensive care unit who were born in 2019-2020 and the first 3 quarters of 2021 were estimated. The frequency of lesions of the nervous system in premature infants, namely the presence of intraventricular hemorrhages of varying severity, hypoxic-ischemic encephalopathy, periventricular leukomalacia, hydrocephalus. Statistical processing of the obtained results was performed using the software system Microsoft Excel 2010 (14.0.6024.1000) SP 1 MSO (14.0.6023.1000).Results. In 2021, the number of premature babies weighing <1,500 g increased compared to 2019. The decrease in mortality rates of premature infants-patients of the intensive care unit was revealed. The most common pathologies of premature infants are respiratory distress syndrome and lesions of the nervous system. Analysis of the obtained data showed that the structure of neurological pathology in premature infants is dominated by hypoxic-ischemic encephalopathy and intraventricular hemorrhage.Conclusions. Against the background of declining mortality rates, the number and severity of HSV in premature infants are increasing.
NEONATAL LEUKEMIA: ASPECTS OF DIFFERENTIAL DIAGNOSIS
Authors: Tsvirenko S. , Artomova N. , Kaliuzhka O. , Hasiuk N. , Zhuk L.
Published: May 2022

Diseases emerging in the neonatal period can manifest themselves only with a limited number of variants of clinical manifestations and laboratory syndromes. Despite this, the etiology of pathological conditions that occur in the neonatal period is very diverse and requires significant reserves of the theoretical base from a neonatologist and a pediatrician who is involved in clinical support and observation of patients of the neonatal period, as well as clinical experience regarding differential diagnosis. Neonatal leukemias refer to malignant processes with a rapid progressive course, which, due to the intensive development of the pathological process, can acquire an incurable character and threaten newborn’s life. Therefore, the issues of differential diagnosis of neonatal leukemias are relevant even despite the low incidence of this pathology among the cohort of neonatal patients.The presented article discusses the main clinical and laboratory syndromes of neonatal leukemia, which can occur as clinical manifestations of other diseases of the neonatal period; specifies the features, as well as the individual characteristics of each of the syndromes in different pathological conditions. Determination of combinations of clinical and laboratory syndromes in generalized infections in the neonatal period, non-malignant hematological diseases and neoplastic processes makes it possible to use these diphenifications in the diagnostic algorithm of neonatal conditions with the definition of further therapeutic tactics for managing a pediatric patient.
MODERN TACTICS OF MANAGING PREMATURE CHILDREN WITH BRONCHO-PULMONARY DYSPLASIA DURING DISCHARGE FROM THE NEONATAL DEPARTMENT AND AT HOME AT THE AMBULATORY STAGE
Authors: Mokiya-Serbina S.
Published: May 2022

Despite significant advances in nursing premature babies, bronchopulmonary dysplasia (BPD), as before, is associated with high morbidity and mortality in children of the first year of life, a high risk of developing chronic pulmonary pathology, which requires the organization of a systematic monitoring system for children from the moment of birth.The article reflects modern ideas about native and foreign tactics of managing premature infants with BPD at the stage of discharge from the neonatal department and at home at the outpatient stage. It is given a detailed description of the conditions that must be observed when discharging children. Attention is focused on the need to assess the severity of BPD, the clinical condition of the child, the level of medical care at the child's place of residence, the social conditions of his life, the willingness of the parents to accept the child. The modern understanding of the role of the follow-up room and palliative service in the provision of medical care to children that are needed in respiratory support is highlighted. We considered the main components of palliative care at home for children with severe BPD. The role of the primary health care physician (pediatrician) in its providing is characterized. The indications and observation periods at the outpatient stage of the pediatric pulmonologist were determined. The expediency and indications for additional examination methods, which a child with BPD needs, have been substantiated.
A CLINICAL CASE OF OSTEOGENESIS IMPERFECT TYPE III, DETERMINED BY COL1A1 (P.GLY845ARG) GENE MUTATION IN A NEWBORN GIRL
Authors: Lastivka I. , Antsupova V. , Babintseva A. , Yurkiv O. , Brisevac L. , Malieieva I.
Published: May 2022

Osteogenesis imperfecta (OI) is a disease that is characterized by hereditary connective tissue dysplasia and is clinically manifested as excessive bone fragility and limb deformity. The overall incidence of OI is 1:10,000-20,000 live births. The main autosomal dominant inheritance path, autosomal recessive and X-linked forms have been established, and sporadic cases of the disease, denovo mutations and familial mosaicism have been described. 85% of cases are connected with mutations in the COL1A1 and COL1A2 genes, which leads to quantitative and qualitative changes in the synthesis of type I collagen. Quantitative defects are due to the formation of a null allele, in which the structure of collagen remains unchanging, and its amount is halved. Out of qualitative defects, the most common type of mutation is associated with the replacement of glycine with a larger amino acid. This leads to a disruption in the formation of the triple chain and structural changes in the type I procollagen molecule.The article presents a clinical case of type III osteogenesis imperfecta caused by a mutation in the COL1a1 (p.Gly845Arg) gene in a newborn girl. Antenatally diagnosed with oligohydramnios and shortening of the limbs, after birth phenotypically revealed congenital dwarfism with short limbs, small size of the cartilaginous skull, hypertelorism, depressed nose bridge and micrognathia. X-ray examination revealed fractures of the humerus. The results of the molecular genetic study revealed the c.2533G>A (p.Gly845Arg) mutation of the COL1A1 gene.Molecular genetic examination of family members (mother, father and two sisters of the proband) did not reveal the pathological allele diagnosed in the proband, that is, the birth of a child with a hereditary pathology of the musculoskeletal system occurred as a result of a new mutation.
THE DIAGNOSTIC VALUE OF ALLERGIC INFLAMMATION MARKERS IN INFANTS WITH BRONCHIOLITIS
Authors: Tokarchuk N. , Overchuk A.
Published: May 2022

Introduction. It is quite important to study the markers of allergic inflammation depending on the status of vitamin D in order to understand the pathogenetic links of bronchiolitis in infants.Aim of study. Analysis of the relationship between serum vitamin D levels and indicators of allergic inflammation (eosinophil cationic protein (ECP) and IgE) in infants with bronchiolitis.Materials and methods. A clinical examination of 55 infants was conducted. The main group consisted of 25 children with bronchiolitis who had a history of allergies. The comparison group consisted of 20 children with bronchiolitis without a burdensome allergy history. The control group included 10 relatively healthy children. The mean age of children in the main group was 7.2 ± 1.4 months, 6.4 ± 1.2 months in the comparison group, and 9.2 ± 1.6 months in the control group.Results of the study. It was found that the duration of hospital stay in children of the main group was 8.2 ± 1.32 days, while in children of the comparison group the duration of stay in hospital was significantly shorter (p <0.05). We found a significant difference in the indicators of allergic inflammation that depended on the status of vitamin D in the examined children. Thus, in children with vitamin D deficiency and insufficiency, a marked increase in ECP (56.3 ± 12.8 ng / ml) and total IgE levels to 127.5 ± 3.12 IU / ml was found compared to the same indicators as in children of the main group with the optimal level of 25 (OH) D, and in children of the comparison group, p˂0,001. It should be noted that the rate of allergic inflammation marker ECP in children of the comparison group with deficiency and insufficiency of vitamin D in serum also had a significant difference when compared with infants of the control group, p˂0.05. Conclusions. In children with bronchiolitis, obtained history of allergies and insufficient levels of vitamin D and its insufficiency, the severity of the disease is manifested by a longer duration of clinical symptoms and hospital stay. Eosinophilic cationic protein can be considered as a marker of allergic inflammation in infants with bronchiolitis.
Une approche centrée sur la personne pour l’analyse des facteurs de stress liés à la pandémie de COVID-19
Authors: Blais Ann-Renee , Blouin Hudon Ève-Marie , Lymburner Matthew
Published: May 2022

Introduction

La pandémie de COVID­19 et les effets du confinement qui en ont découlé ont eu un effet néfaste sur la situation sociale, professionnelle et financière des individus. En adoptant une approche centrée sur la personne pour la recherche d’information et l’analyse des données, nous avons cherché à définir des classes (ou segments) d’employés ayant des configurations spécifiques de réponses relatives à plusieurs facteurs de stress liés à la pandémie. Nous avons également étudié leurs facteurs de risque et de résilience en lien avec l’appartenance à ces classes.

Méthodologie

Nous avons analysé les données de 4 277 employés ayant répondu à un sondage éclair en août 2020, au moyen d’une analyse de classes latentes pour définir les groupes d’employés ayant des modèles spécifiques de réponses à propos de six facteurs de stress liés à la pandémie. Nous avons également effectué une analyse de régression logistique multinomiale pour explorer les liens entre plusieurs facteurs de risque et de résilience (dont l’âge, le sexe et le soutien organisationnel perçu) et l’appartenance à ces classes, puis nous avons comparé les niveaux de santé mentale autodéclarée dans ces classes émergentes.

Résultats

Les données ont révélé quatre classes d’employés : « adaptation », « en tension », « avec insécurité » et « en grand stress » (formant respectivement 30 %, 35 %, 21 % et 14 % de l’échantillon). Tous les facteurs de risque et de résilience ont été évalués en lien avec le fait d’appartenir à la classe « adaptation » plutôt qu’aux autres classes. De plus, les employés de la classe « adaptation » ont présenté un meilleur niveau de santé mentale autodéclarée par rapport aux autres.

Conclusion

Grâce à l’obtention de classes d’employés avec des configurations spécifiques de facteurs de stress liés à la pandémie ainsi que des niveaux de santé mentale autodéclarés et des facteurs de risque différentiels, cette étude offre un point de départ pour éclairer les interventions en contexte professionnel visant à aider les employés les plus vulnérables aux facteurs de stress liés à la pandémie à faire face efficacement à ces derniers.
Imam Ali Ibn Musa al-Ridha (A. S.)-The Exquisite Sun of Bani Hashim
Authors: Fatima Dr. Syeda Farhat
Published: May 2022

Ali Ibn Musa al-Rida was the eighth great grandson of Fatima Zehra (daughter of Prophet Mohammad, peace be upon him) and Ali Ibn Abi Talib and he is also the eighth Imam of Shiite believers.  He was an embodiment of etiquette, manners and charity and he imparted to us the qualities of a believer. His teachings were ‘How a man should strive to be a believer of Allah (S.w.t)?’He highlighted in his preaching’s the ways to seek the pleasure of Allah (s.w.t) was through piousness, tolerance and persistence in our righteous deeds.  He also emphasized us that for a believer to control his/her nafs (psyche)is prominent among his actions.  Because of Imam Ali Ridha’s (a. s.) high moral traits and pleasing personality, he (a. s.) was considered the exquisite sun of Bibi Fatima Zehra and the Bani Hashim clan.  This paper aims to show that Imam Ali Ibn Musa al-Ridha’s reward from Allah (s.w.t) is complete peace of mind as he stuck to his spiritual values being away from his homeland.
Cross-Cultural Human Relationships in Sunetra Gupta’s So Good in Black
Authors: Ramamoorthy Dr. A.R. Uma
Published: May 2022

Sunetra Gupta who is an Indian immigrant living in England and working in Oxford University as a Professor of Zoology has written five novels. Her fifth novel, So Good in Black published in 2011 celebrates globalization and the free passage to western countries for Indians and for the westerners to India. Human relationship is the main crux of postmodern writings and Gupta also brings out the cross-cultural human relationship in So Good in Black with much details. At the backdrop of Kolkata, India, Gupta colourfully draws the human relationship especially man-woman relationship in this novel. As the values of life are at stake due to the materialistic advancement in the modern world, Gupta highlights the fact that human relationship always lies in dark and it is good to keep it in black. The characters namely Byron Mallick, Max Gate, Damini and Ela suffer as they from relationship with themselves and with others who are their kith and kin. The women characters namely, Damini, Ela and Barbara become victims in the hands of Byron and Max, as they try to form relationship among them. The cultural values of India and the West is comparatively discussed by the author in this novel to bring out the very nature of Indian woman like Ela who gives importance to Indian culture and prefers it though she experiences cross-cultural human relationship.