bluuebunny/crossref_metadata_2025 huggingface dataset:
TÌNH HÌNH SỬ DỤNG KHÁNG SINH DỰ PHÒNG TRÊN BỆNH NHÂN PHẪU THUẬT MỔ LẤY THAI TẠI MỘT BỆNH VIỆN TỈNH SÓC TRĂNG NĂM 2022
Authors: Nguyễn Văn Đời , Nguyễn Thắng
Published: September 2023

Đặt vấn đề: Nhiều nghiên cứu gần đây chỉ ra rằng việc sử dụng kháng sinh dự phòng hợp lý làm giảm tỉ lệ nhiễm khuẩn vết mổ, giảm tỉ lệ đề kháng kháng sinh và tiết kiệm chi phí, thời gian nằm viện cho người bệnh. Mục tiêu nghiên cứu: Phân tích tình hình sử dụng kháng sinh dự phòng trên bệnh nhân mổ lấy thai tại một bệnh viện tỉnh Sóc Trăng năm 2022. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang với 345 bệnh án của các bệnh nhân mổ lấy thai được chọn ngẫu nhiên từ 01/07/2022 đến 30/09/2022. Phân tích các đặc điểm về sử dụng kháng sinh dự phòng và các yếu tố liên quan đến việc sử dụng kháng sinh dự phòng hợp lý. Kết quả: Vết mổ cũ là nguyên nhân phổ biến nhất được chỉ định phẫu thuật mổ lấy thai (47%), tỉ lệ nhiễm khuẩn vết mổ chiếm tỉ lệ thấp (1,2%). Tất cả các bệnh án đều có sử dụng kháng sinh dự phòng (100%). Kháng sinh được sử dụng nhiều nhất là Amoxicillin + Acid clavulanic (89%). Tỉ lệ hồ sơ bệnh án có lựa chọn kháng sinh dự phòng không hợp lý là (10,4%), liều dùng kháng sinh không hợp lý là (11%). Các bệnh nhân
<18 tuổi có thể có tỉ lệ lựa chọn kháng sinh hợp lý và liều dùng kháng sinh hợp lý thấp hơn các nhóm bệnh nhân khác (OR <1 và p < 0,05). Kết luận: Amoxicillin + Acid clavulanic là kháng sinh được sử dụng phổ biến nhất trong nghiên cứu. Nguyên nhân dẫn đến việc sử dụng kháng sinh không hợp lý trong nghiên cứu do lựa chọn kháng sinh và liều dùng của kháng sinh không hợp lý. Các bệnh nhân dưới 18 tuổi có thể là yếu tố nguy cơ làm giảm tỉ lệ sử dụng kháng sinh dự phòng hợp lý trong phẫu thuật mổ lấy thai.
NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ PHẪU THUẬT NỘI SOI ĐAU ĐẦU DO TIẾP XÚC VÙNG MŨI TẠI BỆNH VIỆN TAI MŨI HỌNG CẦN THƠ NĂM 2021- 2023
Authors: Lê Bội Ngọc , Châu Chiêu Hòa
Published: September 2023

Đặt vấn đề: Đau đầu do tiếp xúc vùng mũi là một hội chứng đau đầu thứ phát sau các điểm tiếp xúc niêm mạc trong hốc mũi, khi không có dấu hiệu viêm, niêm mạc tăng sản, chảy mủ, polyp hoặc khối u. Bệnh có thể là kết quả của áp lực lên niêm mạc mũi do các biến thể giải phẫu trong đó lệch vách ngăn thường được thấy trên lâm sàng. Mục tiêu nghiên cứu: Xác định tỉ lệ các triệu chứng lâm sàng, cận lâm sàng của đau đầu do tiếp xúc vùng mũi và đánh giá kết quả điều trị phẫu thuật nội soi tại Bệnh viện Tai Mũi Họng Cần Thơ năm 2021-2023. Đối tượng và phương pháp nghiên cứu: Những bệnh nhân đau đầu có điểm tiếp xúc trên hình ảnh học và giảm đau đầu rõ rệt khi làm test điểm tiếp xúc bằng hỗn hợp thuốc tê lidocain 10% và thuốc co niêm mạc. Tất cả bệnh nhân đều được phẫu thuật nội soi để tách điểm tiếp xúc trong hốc mũi. Phương pháp nghiên cứu: Nghiên cứu tiến cứu có can thiệp. Kết quả: Trung bình tổng điểm VAS trước phẫu thuật 5,34 ± 1,88, cải thiện có ý nghĩa thống kê (p<0,001), tại thời điểm 1 tuần 1,98 ± 2,37, 1 tháng (1,09 ± 1,65), 3 tháng (0,45 ± 0,13). Sau phẫu thuật 3 tháng, 91,4% bệnh nhân không còn đau đầu. Các triệu chứng có năng khác đi kèm: nghẹt mũi, chảy mũi, hắt hơi cải thiện rõ rệt. 91,4% bệnh nhân được ghi nhận có kết quả điều trị tốt. Kết luận: Phẫu thuật nội soi điều trị đau đầu do tiếp xúc vùng mũi cho kết quả khả quan, cải thiện chất lượng cuộc sống.
NGHIÊN CỨU ĐẶC ĐIỂM TỔNG PHÂN TÍCH TẾ BÀO MÁU NGOẠI VI VÀ ĐIỆN DI HEMOGLOBIN CÁC THỂ BETA-THALASSEMIA TẠI BỆNH VIỆN HUYẾT HỌC - TRUYỀN MÁU CẦN THƠ NĂM 2021-2022
Authors: Nguyễn Minh Trí , Phạm Thị Nhung , Nguyễn Thị Hồng Nhiên , Lục Trương Khánh Minh , Đỗ Thị Cẩm Tiên , Lê Thị Hoàng Mỹ , Nguyễn Long Quốc , Phạm Hồ Vũ
Published: September 2023

Đặt vấn đề: Việc sàng lọc, chẩn đoán bệnh beta-thalassemia cần dựa vào đặc điểm lâm sàng và kết quả cận lâm sàng. Đồng bằng sông Cửu Long với số người bệnh hoặc mang gen betathalassemia chiếm tỷ lệ cao trong số các bệnh nhân thalassemia nhưng lại có ít các nghiên cứu về khoảng giá trị cận lâm sàng của bệnh, đặc biệt là điện di hemoglobin. Mục tiêu nghiên cứu: Mô tả đặc điểm tổng phân tích tế bào máu ngoại vi và điện di hemoglobin các thể beta-thalassemia. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 45 bệnh nhân betathalassemia đến khám và điều trị tại Bệnh viện Huyết học - Truyền máu Cần Thơ từ tháng 06/202106/2022. Kết quả: Trong 45 trường hợp được chúng tôi nghiên cứu, ghi nhận giá trị trung bình các chỉ số trên kết quả tổng phân tích tế bào máu ngoại vi là: số lượng hồng cầu (RBC) 3,07 ± 0,99x1012/L, số lượng bạch cầu (WBC) 11,75 ± 7,22x109/L, số lượng tiểu cầu (PLT) 355,16 ± 225,22x109/L, nồng độ hemoglobin (Hb) 6,51 ± 1,64 g/dL, thể tích trung bình hồng cầu (MCV) 69,64 ± 9,13 fL, lượng hemoglobin trung bình hồng cầu (MCH) 21,88 ± 3,39 pg và dải phân bố kích thước hồng cầu (RDW) 26,22 ± 6,89%. Đồng thời trên kết quả điện di Hb ghi nhận tỷ lệ HbA1 trung bình là 33,42 ± 37,61%, HbA2 và HbF trung bình lần lượt là 4,71 ± 1,82% và 37,45 ± 26,11%, HbE xuất hiện ở thể beta-thalassemia/HbE với tỷ lệ trung bình 43,86 ± 9,13%. Kết luận: Bệnh betathalassemia làm thay đổi các chỉ số trên kết quả tổng phân tích tế bào máu ngoại vi: RBC, WBC, PLT, Hb, MCV, MCH đều giảm và RDW tăng; đồng thời thay đổi tỷ lệ các thành phần Hb trên kết quả điện di hemoglobin đặc hiệu cho từng thể bệnh.
CÁC YẾU TỐ DỰ ĐOÁN THÁO LỒNG BẰNG HƠI THẤT BẠI TRONG LỒNG RUỘT Ở TRẺ EM TẠI BỆNH VIỆN NHI ĐỒNG THÀNH PHỐ CẦN THƠ
Authors: Lâm Thùy Đoan , Lê Diệp Hải Dương , Lê Thị Thanh Xuân , Trần Quốc Bảo , Ngô Võ Thúy Anh , Võ Quang Huy
Published: September 2023

Đặt vấn đề: Tháo lồng bằng hơi trong điều trị lồng ruột có tỉ lệ thành công cao, tuy nhiên vẫn có một vài trường hợp thất bại cần phải phẫu thuật. Các yếu tố dự đoán tháo lồng thất bại vẫn còn đang được bàn luận và tiêu máu cũng là một trong các yếu tố đó. Mục tiêu nghiên cứu: Xác định tỉ lệ triệu chứng tiêu máu và khảo sát các yếu tố dự đoán tháo lồng bằng hơi thất bại. Đối tượng và phương pháp nghiên cứu: Nghiên cứu tiến cứu mô tả cắt ngang trên bệnh nhi <15 tuổi được chẩn đoán và điều trị lồng ruột bằng phương pháp tháo lồng bằng hơi tại Bệnh viện Nhi đồng thành phố Cần Thơ từ tháng 07/2021 đến tháng 09/2022. Kết quả: 162 bệnh nhi được đưa vào nghiên cứu, trong đó có 86 nam (53,1%), tỉ lệ nam/nữ là 1,13/1. Độ tuổi trung bình là 24,25 ± 14 tháng. Cân nặng trung bình là 11,6 ± 3,7 kg. Tỉ lệ tiêu máu là 22,2%. Tỉ lệ bệnh nhi vào viện <24 giờ chiếm 54,3%. Tỉ lệ tháo lồng bằng hơi thành công là 95,7%. Những yếu tố tiên lượng tháo lồng thất bại bao gồm: trẻ ≤12 tháng, trẻ ≤10 kg, sờ thấy khối lồng, tiêu máu, tam chứng lồng ruột và sự hiện diện của dịch đầu khối lồng trên siêu âm. Kết luận: Khi một bệnh nhi được chẩn đoán lồng ruột cần xem xét những yếu tố dự đoán tháo lồng thất bại để tiên lượng và dự phòng khi điều trị để tránh những biến chứng nghiêm trọng.
BÀO CHẾ GEL RỬA MẶT TỪ KHỔ QUA (Momordica charantia L)
Authors: Bùi Chí Công , Trần Hồng Ngân , Võ Minh Khoa , Nguyễn Thị Linh Tuyền
Published: September 2023

Đặt vấn đề: Quả Khổ qua (Momordica charanta L.) được sử dụng phổ biến ở Việt Nam với nhiều công dụng liên quan đến sức khỏe và chăm sóc sắc đẹp. Tuy nhiên, các nghiên cứu về các chế phẩm làm đẹp từ Khổ qua vẫn còn hạn chế. Mục tiêu nghiên cứu: Bào chế gel rửa mặt từ dược liệu Khổ qua. Đối tượng và phương pháp nghiên cứu: Đối tượng nghiên cứu là dược liệu Khổ qua. Khảo sát ảnh hưởng của tỷ lệ cao đặc Khổ qua (5%; 10%; 15%); tỷ lệ hydroxyethyl cellulose (1%; 1,5%; 2%) và tỷ lệ cocamidopropyl betain (1%, 2%, 3%) đến một số đặc tính của gel rửa mặt Khổ qua như cảm quan, pH, khả năng phân tán bẩn, độ nhớt, khả năng tạo bọt và ổn định bọt. Kết quả: Đã xác định được tỷ lệ cao đặc Khổ qua 10%, tỷ lệ của hydroxyethyl cellulose 1,5%, tỷ lệ của cocamidopropyl betain 3%. Kết luận: Đã bào chế được gel rửa mặt từ dược liệu Khổ qua với thành phần công thức là cao đặc Khổ qua 10%, hydroxyethyl cellulose 1,5%, cocamidopropyl betain 3%, lauryl glucosid 1%, glycerin 5%, acid citric 0,1% và nước cất vừa đủ 100%.
XÂY DỰNG CÔNG THỨC BÀO CHẾ KEM HỖ TRỢ KHÁNG VIÊM TỪ DƯỢC LIỆU TRÀ XANH (CAMELLIA SINENSIS L. THEACEAE), ỔI (PSIDIUM GUYJAVA L. MYRTACEAE) VÀ RAU MÁ (CENTELLA ASIATICA L. APIACEAE)
Authors: Huỳnh Thị Mỹ Duyên , Lê Thị Minh Ngọc , Bùi Kim Ngân
Published: September 2023

Đặt vấn đề: Trên thị trường đã có các sản phẩm chăm sóc da từ dược liệu như sữa rửa mặt Rau má, mặt nạ Trà xanh, serum dưỡng da từ lá Ổi… nhờ vào các nghiên cứu về khả năng chống oxy hóa, kháng khuẩn, kháng viêm… Mục tiêu nghiên cứu: Nghiên cứu thành phần công thức bào chế kem và đánh giá hoạt tính kháng viêm từ dược liệu Trà xanh, Ổi và Rau má. Đối tượng và phương pháp nghiên cứu: Tiến hành xây dựng công thức bào chế kem bằng phương pháp nhũ hóa thông qua các bước khảo sát loại chất nhũ hóa, tỷ lệ pha dầu-nước-chất nhũ hóa. Công thức kem được đánh giá thông qua các chỉ tiêu cảm quan, độ ổn định, độ đồng nhất, độ dàn mỏng, khả năng rửa sạch. Tiến hành đánh giá hoạt tính kháng viêm của chế phẩm trên in vitro. Xây dựng tiêu chuẩn kiểm nghiệm kem theo các quy định hiện hành. Kết quả: Đã chọn được loại chất nhũ hóa, tỷ lệ giữa các pha giúp kem đạt được các chỉ tiêu kiểm nghiệm đã xây dựng. Chế phẩm thu được cho thấy có hoạt tính kháng viêm. Kết luận: Đã nghiên cứu thành công kem chứa dược liệu Trà xanh, Ổi và Rau má đạt tiêu chuẩn và có tác dụng hỗ trợ kháng viêm với IC50 của mẫu thử là: 698,02 µg/mL.
NGHIÊN CỨU VIỆC TUÂN THỦ DÙNG THUỐC CỦA NGƯỜI BỆNH ĐÁI THÁO ĐƯỜNG TÍP 2 TẠI KHOA NỘI TỔNG HỢP BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ
Authors: Trần Thị Như Ngọc , Đặng Minh Tiến , Nguyễn Ngọc Thơ , Bùi Xuân Trà
Published: September 2023

Đặt vấn đề: Tuân thủ điều trị là một vấn đề sức khỏe cộng đồng, đặc biệt quan trọng đối với điều trị bệnh lý mạn tính trong đó có đái tháo đường típ 2. Nếu không được điều trị và quản lý tốt, bệnh có thể dẫn đến nhiều biến chứng nguy hiểm thậm chí tử vong. Tỷ lệ tuân thủ điều trị ở người bệnh tại các quốc gia đang phát triển trong đó có Việt Nam hiện nay còn thấp, theo thống kê trung bình hiện dưới 50%. Mục tiêu nghiên cứu: 1) Xác định tỷ lệ tuân thủ dùng thuốc của người bệnh đái tháo đường típ 2. 2) Xác định một số yếu tố liên quan đến việc tuân thủ dùng thuốc của người bệnh đái tháo đường típ 2. Đối tượng và phương pháp nghiên cứu: người bệnh đái tháo đường típ 2 đang điều trị nội trú tại Khoa Nội tổng hợp, Bệnh viện Trường Đại học Y dược Cần Thơ. Nghiên cứu mô tả cắt ngang. Đối tượng nghiên cứu được chọn theo cách chọn mẫu thuận tiện. Kết quả: Bệnh nhân có tỷ lệ quên thuốc viên cao (90,7%). Lý do quên thuốc thường gặp nhất là do bận (76,2%). Xử lý quên thuốc đa số là uống bù vào lần uống sau (71,5%). 75% người bệnh có thời gian mắc bệnh ≤5 năm thỉnh thoảng quên hoặc bỏ thuốc, người bệnh tuân thủ điều trị với việc uống thuốc đều đặn đa số thuộc nhóm được kê đơn dùng thuốc từ 1-2 lần trong ngày (96,2%). Kết luận: Tỷ lệ tuân thủ thuốc cao. Thuốc thường quên là thuốc dạng viên. Xử trí chủ yếu khi là uống bù lần sau. Thời gian mắc bệnh dài, số lần dùng thuốc từ 3 trở lên, thời gian điều trị 1-5 năm là những yếu tố làm giảm tỷ lệ tuân trị.
Administration on Revenue Generation in South Sudan: A Case Study of the National Revenue Authority and Ministry of Finance and Planning
Authors:   University of Juba, South Sudan, DENG AKECH AYAK MAJAK
Published: September 2023

The study aimed to assess the impact of tax administration on revenue generation in South Sudan, using a descriptive approach and a case study of the National Revenue Authority and Ministry of Finance and Planning. The research employed purposive sampling and interviews for further analysis Findings for this study were derived from tax revenue and tax administration in the National Revenue Authority and Ministry of Finance and Planning, where investigation was carried out in areas of narrow tax base, culture of the inhabitants and manpower issues, taxpayer's awareness, receipts misappropriation and inefficiency, as well as ineffectiveness and inefficiency, which were confirmed to be causes of low revenue generation in South Sudan. As a result of the findings, it was determined that it was necessary to increase the tax base by enacting new taxes like the super profit tax and the value-added tax (VAT), increase tax payer awareness to improve collection, and develop strategies to address the manpower shortage by hiring qualified, energetic, and motivated employees; provide incentives and bonuses to tax officials to reduce receipts misappropriation; and regularly train tax officials to improve their capacities and, as a result, their effectiveness and efficiency in generating revenue.
Polarisation of Policy Reponses to the COVID-19 among ASEAN Countries
Authors: Selvarajan Sonia Kumari , Ab-Rahim Rossazana
Published: September 2023

COVID-19 pandemic effects are heterogenous in nature due to the differences in policy responses among the nations, with no exception to Association of Southeast Asian Nations (ASEAN). COVID-19 responses undertaken by individual member countries of ASEAN have been tremendously diverse and have ranged from strict lockdown conditions in the highly regulated city-state of Singapore to ‘business as usual’, especially in rural areas of developing countries with large informal economies such as Laos and Myanmar. Studies on the nexus between concerted regional effort and the consequences of the pandemic appear to be limited; thus, this study aims to investigate the polarisation of the policy responses among the individual ASEAN countries. Examining the polarisation trend offers an insight on the responses of the nations towards handling the COVID-19 pandemic. This study employs Philipps and Sul method to test the convergence of the polarisation of ASEAN countries.
ON THE PERFORMANCE OF SOME BIASED ESTIMATORS IN A MISSPECIFIED MODEL WITH CORRELATED REGRESSORS
Authors: Chandra Shalini , Tyagi Gargi
Published: September 2023

In this paper, the effect of misspecification due to omission of relevant variables on the dominance of the 𝑟 −(𝑘, 𝑑) class estimator proposed by Özkale (2012), over the ordinary least squares (OLS) estimator and some other competing estimators when some of the regressors in the linear regression model are correlated, have been studied with respect to the mean squared error criterion. A simulation study and numerical example have been demostrated to compare the performance of the estimators for some selected values of the parameters involved.
THE APPLICATION OF MULTIVARIATE STATISTICAL ANALYSIS TO THE VALUATION OF DURABLE GOODS BRANDS
Authors: Dziechciarz-Duda Marta , Król Anna
Published: September 2023

Nowadays, due to changes in the market and new trends in consumer behaviours, intangible assets, such as brand, have gained fundamental importance. The more frequent conviction that a product with a well-known name is better than other products contributes to the case of replacing the price of a product by its brand name as the predominant factor in the purchase decision process. Thus, for many companies the strengthening of brand equity has become one of the key elements of marketing strategy. The main aim of this study is an attempt to improve the process of analysing the position and value of brands using selected multivariate statistical analysis methods (hedonic regression, multidimensional scaling, classification and linear ordination methods). In the conducted research the direct approach to the evaluation of the position of the brands for a selected ICT good smartphones – have been applied. The measurement was performed on two levels: the product level, in which the prices of branded products were compared, and the consumer level, where the perception and attitudes of consumers towards the brands were studied. The analyses have been carried out on two sets of data, which enabled fuller and more comprehensible understanding of decision rules that guide consumers in choosing the brand.
On Quantifying the Rotatability of the Hybrid Designs
Authors: Ohaegbulem Emmanuel U.
Published: September 2023

A procedure of assessing the rotatability for the Hybrid Designs (HDs) was presented and illustrated. Measuring the rotatability of the three three-variable Hybrid Designs by Roquemore (1976), for example, using the procedure, the rotatability values obtained were quite the same as the values obtained using the procedures and measures presented by other authors. Khuri (1988), Draper and Pukelsheim (1990) and Kshirsagar and Cheng (1996) obtained the rotatability values for the Hybrid Designs, (()3,10HD, ()3,11AHD and ()3,11BHD) to be (94.89%, 99.40% and 98.99%), (99.03%, 99.93% and 99.69%) and (97.16%, 99.82% and 98.46%), respectively. Interestingly, the proposed procedure in this study, and using the measure by Ohaebgulem and Chigbu (2021), yielded 97.16%, 99.82% and 98.46%, respectively, for the same three hybrid designs. The beauty of this procedure is that it has nothing to do with the viewing of contour diagrams, and it is also simple to use.
A New Approach for Effective Reliability Management of Biomedical Equipment
Authors: Roy Chowdhuri Isha , Kar Avijit , Pal Arun Kiran
Published: September 2023

Within the modern hospitals, an increasingly common problem is the efficient management of the maintenance of biomedical equipment. If effective management of medical equipment maintenance is applied, quality health services could be provided by reducing the downtime of medical equipment as well as by decreasing the recovery time for treatment of patients. Risk based maintenance strategy helps in designing an alternative methodology to minimize the risk by identifying the breakdown pattern and then increasing the reliability. The probability of failures that obstruct the reliability can be influenced by some technical, administrative or management actions. The proposed study is based on the analysis of reliability and availability for maintenance planning on the basis of risk index and fault tree analysis. Maintenance of equipment is prioritized based on the risk which helps in reducing the overall risk of the hospital. Fault tree diagram is also developed to understand the actual scenario where highest priority or risk events are sequentially arranged. Failure probability for different biomedical equipment has been established by applying statistical method. It has been observed that Magnetic Resonance Imaging has the lowest risk index while X-Ray has the highest risk index. Also, maintenance planning has been suggested based on the reduction of risk factor to meet the acceptable criteria and reduce the probability of failure. This approach depicts that reliability of equipment is increased after implementation of maintenance planning proposed which contributes to the availability of the equipment as well as its safe operation.
Efficacy of Psychoeducation in Borderline Personality Disorder: Results of a Mirror Study
Authors: Martín-Vázquez María-José , Crespo-Medina María-del-Mar , Sekade-Gutiérrez Nuria
Published: September 2023

Background and objectives: Personality disorders are increasing their prevalence in clinical population, and they use many resources that frequently are scarcely efficient. Group therapy has demonstrated its efficacy, but it has a high cost in time and personal resources. Psychoeducation has proved its efficacy for other diagnosis, but there are few studies that develop this approach. Some authors propose psychoeducation as an efficient pre-treatment in this population. Our objective is to evaluate if this intervention in Borderline Personality Disorder (BPD) patients could influence over the number of emergency room visits and / or psychiatric hospitalization days. Methods: This is a mirror study comparing number of emergency visits and hospitalization days, during the previous and posterior six months to the psychoeducation group. These data are already compared relating to the assistance to that group (regular, irregular or never). Results: the patients that assist regularly to the psychoeducation group reduce their number of emergency visits and hospitalization days during the period after the participation. This effect is not observed in the other two groups, though the three groups have similar clinical data. Conclusions: Psychoeducation group seems to be cost-efficient in the treatment of patients with borderline personality disorder, reducing urgencies and hospitalization days and facilitating the inclusion in more exigent therapeutic groups.
Matomo Analytics unter der Lupe: Wie datenintensiv die drei Tracking-Varianten im Vergleich sind
Authors: Baetz Alexander
Published: September 2023

Wer das Besuchsverhalten auf der eigenen Website analysieren will, kann sich dafür das Programm Matomo installieren. Umfang und Tiefe der Datenabfragen lassen sich mit einigen Kniffen individuell einstellen. Die Einstellungen sind Abwägungssache, wie Alexander Baetz anhand dreier Varianten getestet hat.
MANAJEMEN KONFLIK PERORANGAN TERHADAP PERAN TANGGUNG JAWAB AYAH IBU DALAM STATUS KELUARGA
Authors: Laia Serfin Anna , Dianto Golan
Published: September 2023

Konflik adalah aktivitas atau sumber daya yang menakutkan, pengaruh negatif yang terjadi dalam satu organisasi kelompok atau keluarga. Dalam konteks konsep abstrak, kehadiran suami yang tidak mengenali perannya dalam pernikahan dapat menimbulkan dampak negatif yang signifikan. Suami yang tidak memahami dan melaksanakan perannya sebagai kepala keluarga dengan baik dapat mengakibatkan ketidakseimbangan, ketidakharmonisan, dan kebingungan dalam hubungan pernikahan, ketika suami tidak mengenali peran dan tanggung jawabnya, hal ini dapat menyebabkan ketidakjelasan dalam pengambilan keputusan dan kepemimpinan keluarga. Keluarga dapat mengalami ketegangan, ketidak pastian, dan kebingungan dalam hal pengaturan keuangan, pendidikan anak, pengelolaan rumah tangga, dan aspek-aspek penting lainnya. Manajemen konflik perorangan terhadap peran tanggung jawab ayah dan ibu ini menggunakan metode penelitian kualitatif deskriptif yang mengandung pemahaman konflik dasar yang terjadi dalam keluarga. Dengan hasil yang diperoleh bahwa sebuah keluarga pasti menghadapi konflik, komunikasi dan peranan aktif dari Ayah atau Ibu menjadi kunci untuk menuntaskan masalah baik dan membutuhkan ketekunan dan kemauan untuk terus belajar tentang Firman Tuhan.Conflict is a frightening activity or resource, a negative influence within a group or family organization. In the context of an abstract concept, the presence of an unrecognized husband in a marriage can have a significant negative impact. Husbands who do not understand and carry out a waiver as head of the family properly can cause quarrels, disharmony, and confusion in marital relations. When husbands do not recognize their roles and responsibilities, this can lead to ambiguity in decision-making and family leadership. Families can experience tension, uncertainty, and confusion regarding financial arrangements, children's education, household management, and other essential aspects. Handling individual conflicts over the roles of responsibilities of fathers and mothers uses descriptive qualitative research methods, which contain fundamental conflicts that occur in the family. With the results that a family must face conflict, communication and the active role of the father or mother is the key to solving good problems and requires resilience and a willingness to continue learning about God's Word.
PENTINGNYA KETELADANAN GURU PENDIDIKAN AGAMA KRISTEN TERHADAP PEMBENTUKAN KARAKTER SISWA
Authors: Laia Fermina
Published: September 2023

karakter Dilakukan di sekolah karena kurangnya citra karakter yang kuat Pendidikan karakter pun berhasil dalam keadaan yang baik, tetapi dapat diteladani Dukungan pembuatan karakter. Salah satunya adalah tersedianya role model. Teladan adalah sesuatu yang patut diteladani dalam hal sikap, perilaku dan nilai. Pendidik adalah tokoh utama dalam lingkungan pendidikan dasar teladan bagi siswa. Pendidik tidak hanya di lingkungan sekolah, tetapi juga di Dalam lingkungan keluarga dan masyarakat seperti guru, orang tua dan tokoh masyarakat. Untuk mempermudah tercapainya tujuan pendidikan karakter, maka perlu ditetapkan Keteladanan dalam setting pembentuk karakter sebagai bagian dari komponen penguatan karakter siswa. Oleh karena itu, pendidikan karakter di sekolah sangatlah penting. Berikan contoh kepada siswa yang diajari. Guru dapat menciptakan nilai, sikap, dan perilaku, siswa memiliki pemahaman tentang nilai-nilai, dan pemahaman serta keyakinan terhadap nilai-nilai dari orang dalam situasi yang ingin dijadikan contoh.
Primeros registros del Saltarín cabeza de fuego Machaeropterus pyrocephalus en Colombia
Authors: Carantón-Ayala Diego
Published: September 2023

Presento los primeros registros del Saltarín cabeza de fuego (Machaeropterus pyrocephalus) en Colombia con base en una observación y tres individuos colectados en abril de 2022 en El Encanto, departamento del Amazonas, sobre la ribera del río Putumayo en límites con Perú. Esta especie habita gran parte de la cuenca amazónica con poblaciones principalmente en Brasil, Bolivia y Perú, además cuenta con reportes en Venezuela. La distribución de la especie es amplia y más conocida en el área sur, mientras los registros al norte de la Amazonía son pocos y dispersos. Las vocalizaciones son sutiles y las hembras e inmaduros en el género son bastante similares. Destacamos aspectos para su diferenciación e identificación en campo que permitan registrar su presencia en nuevas localidades.
Proposed Technique for Accurate Detection/Segmentation of Lung Nodules using Spline Wavelet Techniques
Authors:   Department of ICE Anna University Of Technology, Chennai, India, Kumar T. K. Senthil , Ganesh E. N. ,   Rajalakshmi Institute of Technology, Anna University, Chennai, India
Published: September 2023

In this paper we are going to discuss and analyze the different methods which are developed to detect the Lung nodules which cause the lung cancer. At the end of analyzing different methods, the new methodology of detecting the lung nodules using Spline Wavelet technique has been proposed in this paper. Continuous modeling of data often required in medical imaging, Polynomial Splines are especially useful to consider image data as continuum rather than discrete array of pixels. The multi resolution property of Splines makes them prime candidates for constructing wavelet bases. Wavelet tool also let us to compress the original CT image to greater factor without any sacrifice in accuracy of nodule detection. Different Algorithms for segmentation/ detection of lung nodules from CT image is discussed in this paper.
Cytogenetic Profile of de novo Acute Myeloid Leukemia Patients in Malaysia
Authors:   Hematology Unit, Cancer Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia, Meng Chin Yuet , Noor Puteri J. , Ismail Azli , Ahid Mohd Fadly Md , Zakaria Zubaidah
Published: September 2023

Acute myeloid leukemia (AML) is a heterogeneous disease in terms of cytogenetics and molecular genetics. AML is the most common acute leukemia in adults and its incidence increases with age. Diagnostic cytogenetics is an important prognostic indicator for predicting outcome of AML. We examined the karyotypic patterns of 480 patients with de novo AML seen at government hospitals throughout the country and evaluated the association of chromosome aberrations with the age of patient. Chromosome abnormalities were detected in 146 (30.4%) patients. The most common cytogenetic abnormality was balanced translocation t (8; 21), followed by trisomy 8 (as sole abnormality) and t (15; 17). The age of our Malaysian patients at diagnosis ranged from four months to 81 years, with a median age of 39 years. The normal karyotype was found mainly in patients aged 15-30 years. About 75% of patients with t (8; 21) were below 40 years of age, and the complex karyotype was found with the highest frequently (34.3%) in elderly patients (age above 60 years). More than half of the patients with complex karyotype were above 50 years of age. The deletion 5q was detected only in patients aged above 50 years. Different cytogenetic abnormalities in AML show different frequencies with increasing age. Probably different genetic mechanisms are involved in the pathogenesis of AML and these mechanisms might occur at different frequencies over lifetime.
Spectrophotometric Methods for the Determination of Linagliptin in Binary Mixture with Metformin Hydrochloride and Simultaneous Determination of Linagliptin and Metformin Hydrochloride using High Performance Liquid Chromatography
Authors:   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, British University in Egypt, El-Sherouk city, Cairo 11837, Egypt, Ayoub Bassam M. , El-Bagary Ramzia I. , Elkady Ehab F. ,   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt
Published: September 2023

Simple, accurate and precise Zero order, first derivative spectrophotometric and chromatographic methods have been developed and validated for the determination of linagliptin (LNG) and metformin HCl (MET). The zero order and first derivative spectrophotometric methods were used for the determination of LNG in the range of 5-30 μg mL-1 by measuring the absorbance at 299 nm and 311 respectively. Besides, a reversed-phase liquid chromatographic (RP-LC) method is described for the simultaneous determination of LNG and MET. Chromatographic separation was achieved on a Symmetry® Waters C18 column (150 mm × 4.6 mm, 5 μm). Isocratic elution based on potassium dihydrogen phosphate buffer pH (4.6) - methanol (30:70, v/v) at a flow rate of 1 mLmin-1 with UV detection at 260 nm was performed. Linearity, accuracy and precision were found to be acceptable over the concentration ranges of 0.125-4 μg mL-1 and 20-800 μg mL-1 for LNG and MET, respectively. The results were statistically compared using one-way analysis of variance (ANOVA). The optimized methods were validated and proved to be specific, robust, precise and accurate for the quality control of the drugs in their pharmaceutical preparation.
A Novel Assessment of Various Bio-Imaging Methods for Lung Tumor Detection and Treatment by using 4-D and 2-D CT Images
Authors:   Research scholar, Anna University, Chennai, Judice A. Antony , Geetha Dr. K. Parimala ,   Department of ECE, PJCE, India
Published: September 2023

Lung Cancer is known as one of the most difficult cancer to cure, and the number of deaths that it causes generally increasing. A detection of the Lung Cancer in its early stage can be helpful for Medical treatment to limit the danger, but it is a challenging problem due to Cancer cell structure. Interpretation of Medical image is often difficult and time consuming, even for the experienced Physicians. The aid of image analysis Based on machine learning can make this process easier. This paper describes fully Automatic Decision Support system for Lung Cancer diagnostic from CT Lung images. Most traditional medical diagnosis systems are founded on huge quantity of training data and takes long processing time. However, on the occasion that very little volume of data is available, the traditional diagnosis systems derive defects such as larger error, Time complexity. Focused on the solution to this problem, a Medical Diagnosis System based on Hidden Markov Model (HMM) is presented. In this paper we describe a pre-processing stage involving some Noise removal techniques help to solve this problem, we preprocess an images (by Mean Error Square Filtering and Histogram analysis)obtained after scanning the Lung CT images. Secondly separate the lung areas from an image by a segmentation process (by Thresholding and region growing techniques). Finally we developed HMM for the classification of Cancer Nodule. Results are checked for 2D and 4D CT images. This automation process reduces the time complexity and increases the diagnosis confidence.
Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis
Authors:   Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India, Rajendran Peramaiyan , Ekambaram Ganapathy , Sakthisekaran Dhanapal ,   Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India, Nishigaki Ikuo , Nishigaki Yutaka ,   NPO-International Laboratory of Biochemistry, 1-166, Uchide, Nakagawa-ku, Nagoya 454-0926, Japan, Jayakumar Thangavel ,   Department of Pharmacology and Environmental Toxicology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India, Vetriselvi Jayabal ,   Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College, Poondi, Thanjavur, India
Published: September 2023

The immunomodulatory activity of mangiferin was studied in various groups of animals. For this study, adult Swiss albino male mice were treated with benzo(a)pyrene, abbreviated as B(a)P, at 50 mg/kg body weight orally twice a week for 4 weeks; and mangiferin was also given orally (pre- and post-initiation of carcinoma) at 100 mg/kg body weight. Immunocompetence and immune complexes as measured by phagocyte index, avidity index, and soluble immune complex (SIC) levels (p<0.001), as well as NBT reduction, were decreased in the B(a)P-treated animals;whereas increased levels of immunocompetence were noted in the mangiferin-treated animals given B(a)P (p<0.001, p<0.05). The levels of immunoglobulins such as IgG and IgM were decreased considerably (p<0.001) in the B(a)P-treated animals compared with their levels in the control animals; whereas the IgA level was increased (p<0.001). In the mangiferin-treated experimental animals given B(a)P, the levels of IgG and IgM were significantly (p<0.001, p<0.05) increased whereas the IgA level was decreased compared with those for the B(a)P-treated mice. Oxidative changes in lymphocytes, neutrophils, and macrophages were also measured. The enhanced lipid peroxidation and decreased catalase and superoxide dismutase activities found in the lymphocytes, polymorphonuclear cells (PMN), and macrophages from B(a)P-treated mice were significantly reduced and increased, respectively, by the mangiferin treatment. This study confirms the immunomodulatory effect of mangiferin and shows an immunoprotective role arbitrated through a reduction in the reactive intermediate-induced oxidative stress in lymphocytes, neutrophils, and macrophages.
Sensitive Method for the Quantitative Determination of Risperidone in Tablet Dosage Form by High-Performance Liquid Chromatography Using Chlordiazepoxide as Internal Standard
Authors:   Analytical Biochemistry Laboratory, Department of Chemistry, Faculty of Science, University of Aleppo, Aleppo, Syria, Ashour Safwan , Kattan Nuha ,   Analytical Biochemistry Laboratory, Department of Chemistry, Faculty of Science, University of Aleppo, Aleppo, Syria
Published: September 2023

A selective, sensitive and simple reversed-phase HPLC method for the determination of risperidone in bulk powder and pharmaceutical formulations was developed and validated. Risperidone can be separated on a Supelcosil LC8 DB column (250 mm × 4.6 mm i.d., 5 μm particle size) at 40°C with a mobile phase of methanol and 0.1 M ammonium acetate pH 5.50 (60:40, v/v), pumped at flow rate 1.0 mL min-1 and detected at 274 nm. Chlordiazepoxide hydrochloride was used as internal standard. The retention time of risperidone and chlordiazepoxide hydrochloride was found to be 5.89 and 7.65 min, respectively. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. The linear range was 4.0-275.0 µg mL-1 (r2=0.9998) with limits of detection and quantification values of 0.48 and 1.59 μg mL-1, respectively. The precision of the method was demonstrated using intra- and inter-day assay RSD values which were less than 3.27%, while the recovery was 99.00-101.12% (n=5). According to the validation results, the proposed method was found to be specific, accurate, precise and could be applied to the quantitative analysis of risperidone in raw material and tablets.
Misleading Elevation of Troponin T caused by Polymyositis
Authors:   14511 Pine Court, Riverside, CA, 92503, USA, Dhir Teena , Jiang Ning ,   Prince George's Hospital Center, 3001 Hospital Drive, Cheverly, MD, 20785, USA
Published: September 2023

Background: Elevations of cardiac enzymes are commonly used to indicate myocardial ischemia, but they can be elevated due to other conditions. Different forms of Troponin (cTnT, sTnT, cTnI), can cause cross-reactivity in the Troponin T assay, leading to false positives. This report describes a patient with polymyositis who had elevated Troponin T, but no cardiac abnormalities. The purpose is to show that Troponin T, which is believed to be solely from cardiac muscle breakdown, can be seen in inflammatory muscle disease, so Troponin I should be used instead. Description: This is a case report of a 70-year-old woman with a history of diabetes, hypertension, gout and polymyositis, who presented with one-day history of lightheadedness and abdominal pain. To rule out myocardial ischemia, cardiac enzyme testing was ordered which showed elevated CK, CK-MB, and Troponin T. A full cardiac workup was performed which showed no signs of ischemia. Troponin I was <0.05 ng/mL, (normal). Discussion: In inflammatory myositis, there are elevations in many cardiac markers due to non-cardiac causes, which could be related to muscle regeneration and gene expression. This is not seen certain isoforms of Troponin I, specifically cardiac Troponin I. Conclusion: In patients with history of diabetes and other comorbidities, silent myocardial ischemias should be ruled out. Non-cardiac elevations in Troponin T can be seen in patients with inflammatory, so Troponin I should be ordered to get an accurate interpretation. Patients with inflammatory myopathies can have elevations in CK, CK-MB, and Troponin T, but not Troponin I.
Effects of Chinese Herbal Compound "Xuemai Ning" on Rabbit Atherosclerosis Model and Expression of ABCA1
Authors:   Department of Geriatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China, Chen Min
Published: September 2023

Objective: To observe the lipid and the pathological changes of carotid artery smooth muscle cells in atherosclerotic rabbits, verification of Chinese herbal compound which has improve blood lipid and anti atherosclerosis effects, focus on ABCA1 as the key receptor which participated in reverse cholesterol transport, to study the mechanism of Chinese herbal compound (Xuemai Ning). Materials and methods: 30 rabbits were randomly divided into blank group, model group and Chinese herbal compound (Xuemai Ning) group, The model group and the Xuemai Ning group with high fat diet and injection of vitamin D3, causing atherosclerosis model 4 weeks after the intervention of traditional Chinese medicine group, In the 4th week after Xuemai Ning group received the intervention of Chinese herbal compound. Blood lipid, the carotid artery pathological changes and expression of ABCA1 gene and protein in peritoneal macrophage surface were detected after 8 weeks. Results: The carotid artery atherosclerotic plaque formation of the model group was obvious, the carotid atherosclerotic changes of the Xuemai Ning group rabbit significantly lighter than the model group. The serum lipid of model group and Xuemai Ning group were higher than that of the blank group; and the traditional Chinese medicine can up the expression of ABCA1 protein, higher than those in the model group. Expression of macrophage ABCA1 in model group was significantly up regulated at protein level higher than the blank group; and the traditional Chinese medicine can up regulate the expression of ABCA1 protein, higher than those in the model group. Expression of ABCA1 mRNA was significantly up regulated in model group, ABCA1 mRNA of Xuemai Ning group raised more significantly. Conclusion: Xuemai Ning can reduce triglyceride, total cholesterol and low density lipoprotein of hyperlipidemia model in rabbits serum, increase high density lipoprotein, remove foam cells in atherosclerotic cells, improve pathological of AS and up-regulate ABCA1 gene and protein so as to effectively inhibit atherosclerotic disease.
Novel Antibacterial Activity of Lactococcus Lactis Subspecies Lactis Z11 Isolated from Zabady
Authors:   Department of Botany and Microbiology, Faculty of Science, Zagazig University, Egypt, Enan Gamal , Abdel-Shafi Seham , Negm Sally ,   Department of Botany and Microbiology, Faculty of Science, Zagazig University, Egypt, Ouda Sahar ,   Department of Plant Research, Nuclear Research Center, Atomic Energy Authority, Egypt
Published: September 2023

The purpose of this study was to select and characterize a probiotic bacterium with distinctive antimicrobial activities. In this respect, Lactococcus lactis subspecies lactis Z11 (L. lactis Z11) isolated from Zabady (Arabian yoghurt) inhibited other strains of lactic acid bacteria and some food-born pathogens including Listeria monocytogenes, Bacillus cereus and staphylococcus aureus. The inhibitory activity of cell free supernatant (CFS) of L. lactis Z11 isolated from zabady was lost by proteolytic enzymes, heat resistant. Consequently, the active substance(s) of CFS was characterized as a bacteriocin. This bacteriocin has been shown to consist of protein but has no lipidic or glucidic moieties in its active molecule. Its activity was stable in the pH range 2.0 to 7.0 and was not affected by organic solvents. The L. lactis Z11 bacteriocin was produced in CFS throughout the mide to the late exponential phase of growth of the producer organism and maximum bacteriocin production was obtained at initial pH 6.5 at incubation temperature of about 30°C.
Preoperative Topical Hypothermia used in Prolonged Severe Lower Limb Ischemia to Avoid Ischemic Damage - The First Clinical Experience
Authors:   Department of Cardiothoracic and Vacular Surgery and Cardiothoracic Anesthesia, Linkoping University Hospital, Sweden, Szabo Zoltan , Forsell Claes , Aberg Jonas ,   Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
Published: September 2023

Severe lower limb ischemia TASC IIB/III with sensory and motor neurologic deficiencies leads to prolonged hospital care, amputation, and death in 20-70 % of cases. We present our first clinical experience of the use of preoperative topical hypothermia to improve muscular viability in these patients. Two hours after onset of symptoms, six 4-liter plastic bags were filled with snow and packed against the ischemic leg which was protected from frost injury by a layer of towels. After surgical revascularization four hours later muscular and neural functions in the leg were completely restored. A maximum serum myoglobin of 6500 ng/L (median 12000 ng/L in similar but untreated patients) postoperatively decreased to 1400 ng/L after 27 hours.
Conformational Changes of Congenital FVII Variants with Defective Binding to Tissue Factor ARG304GLN (FVII Padua), ARG 304TRP (FVII Nagoya) and ARG79GLN (FVII Shinjo or Tondabayashi)
Authors:   Department of Medicine, University of Padua Medical School, Padua, Italy, Girolami Antonio , Vettore Silvia , Sambado Luisa ,   Department of Medicine, University of Padua Medical School, Padua, Italy, Cristiani Andrea , Moro Stefano ,   Department of Pharmaceutical and Pharmacological Sciences, Padua, Italy, Bulfone Alessandro ,   CRS4 - Biomedicine Sector, Cagliari, Italy
Published: September 2023

Background: The relation between Factor VII (FVII) and tissue thromboplastin is not completely clarified, yet. Three FVII abnormalities, FVII Padua (Arg304Gln), FVII Nagoya (Arg304Trp) and FVII Shinjo or Tondabayshi (Arg79Gln) show different FVII activity according to the tissue Tissue Factor (TF) used in the assay system (rabbit brain, human placenta or human recombinant and ox brain). Objectives: To investigate the possible existence of common conformational changes with regard to different tissue factors in these three FVII variants. Material and methods: Crystal structure analysis and “visual inspection” of FVII were deeply performed to select a crystallographic template for the in silico mutagenesis procedure of FVII Arg79Gln, Arg304Gln and Arg304Trp.100ns 300K NVT large-scale molecular dynamics simulation on GPU were applied to the models of FVII. The aims of this run was to describe at molecular level the influence of the mutation on the protein structure and function. Results: The molecular modelling of those three variants has shown common features in spite of the different location of the mutation involved (the first epidermal growth factor for the Arg79Gln and the catalytic region for the Arg304Gln or Arg304Trp). Molecular dynamics studies have shown in fact that the mutant FVII, shows a decreased flexibility or freezing of the protein conformation of FVIIa with regard to TF. This results in the formation of a defective FVIIa-TF complex that justifies the different clotting results observed in these variants according to the TF used. Conclusions: The conformational studies may supply useful information on the structure- function relation of clotting factors.
Selection of a Suitable Disc Bioassay for the Screening of Anti-Tumor Molecules
Authors:   Centre de Biotechnologie de Sfax (Universite de Sfax). Route de Sidi Mansour Km 6, BP 1177, 3018 Sfax, Tunisia, El Arbi Mehdi , Pigeon Pascal , Top Siden ,   Chimie ParisTech (Ecole Nationale Superieure de Chimie de Paris), Laboratoire Charles Friedel, UMR CNRS 7223, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France, Trigui Fatma , Jalleli Karim , Aifa Sami ,   Centre de Biotechnologie de Sfax (Universite de Sfax). Route de Sidi Mansour Km 6, BP 1177, 3018 Sfax, Tunisia
Published: September 2023

The crown gall induced in potato discs by Agrobacterium tumefaciens is becoming largely utilised in screening anti-tumor agents. The present work is showing that beet discs are more adequate for the anti-tumor screening test. In fact, maximal tumor induction was observed on beet discs (87.5%), followed by carrot discs (75%) and potato discs (68.5%). Beet discs present the most sensibility to crown gall disease with a fast expression of symptoms and more visible galls without any staining need. The beet discs bioassay was carried out by using some synthesized organometallics known for their antitumor activity in mammalian cells. We found significant crown gall inhibition (20.7% to 40.55%) of the tested compounds. Overall results supported that beet bioassay might be a potential prescreen system of anti-tumor molecules in mammalian cells.