bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression
Authors: Wen Yu , Li Jiadong , Koo Jasmine , Shin Seung-Shick , Lin Yong , Jeong Byeong-Seon , Mehnert Janice M. , Chen Suzie , Cohen-Sola Karine A. , Goydos James S.
Published: March 2023

PDF file - 612KB, Supplemental Figure 2: IL8 and VEGF levels in conditioned media were decreased by treatment with inhibitors of GRM1/AKT/mTOR/HIF1 signaling.
Supplementary Figure Legends from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: March 2023

PDF file - 144K
Data Supplement from Heparanase Cooperates with Ras to Drive Breast and Skin Tumorigenesis
Authors: Boyango Ilanit , Barash Uri , Naroditsky Inna , Li Jin-Ping , Hammond Edward , Ilan Neta , Vlodavsky Israel
Published: March 2023

Supplementary Figure 7: DMBA or TPA as single agent do not elicit tumor formation in control and Hpa-Tg mice.
Supplementary Figure 2 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: March 2023

PDF file - 781K, Figure. S2. Treatment with MDV3100 could inhibit RCC cells migration, invasion and proliferation.
Supplementary Figure 3 from Tumor Suppressor Alterations Cooperate to Drive Aggressive Mesotheliomas with Enriched Cancer Stem Cells via a p53–miR-34a–c-Met Axis
Authors: Menges Craig W. , Kadariya Yuwaraj , Altomare Deborah , Talarchek Jacqueline , Neumann-Domer Erin , Wu Yue , Xiao Guang-Hui , Shapiro Irina M. , Kolev Vihren N. , Pachter Jonathan A. , Klein-Szanto Andres J. , Testa Joseph R.
Published: March 2023

PDF - 692K, c-Met activity is required for cell migration and invasion in MM cells from Nf2 (+/-);p16/p19 (+/-) mice. A) MM cell lines 380 and 129 were grown to confluence and subjected to a wound healing assay in presence or absence of c-Met inhibitor SU11274 (photos shown taken at 0 h and 24 h). Immunoblot analysis for P-c-Met, c-Met, P-AKT, P-ERK and ERK1/2 levels was performed 24 h post-treatment with SU11274. B) Results of Matrigel invasion assays performed with MM cell lines 87, 129 and 380 from Nf2+/-;p16/p19+/- mice, and MM cell line 680 from WT mouse, in presence or absence of SU11274. Invading cells stained with crystal violet, 24 h after treatment with vehicle or SU11274.
Supplementary FIgure S8 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: March 2023

Figure. S8. Treatment with ASC-J9 could inhibit RCC cells migration, invasion and proliferation.
Supplementary Figure 1 from Tumor Suppressor Alterations Cooperate to Drive Aggressive Mesotheliomas with Enriched Cancer Stem Cells via a p53–miR-34a–c-Met Axis
Authors: Menges Craig W. , Kadariya Yuwaraj , Altomare Deborah , Talarchek Jacqueline , Neumann-Domer Erin , Wu Yue , Xiao Guang-Hui , Shapiro Irina M. , Kolev Vihren N. , Pachter Jonathan A. , Klein-Szanto Andres J. , Testa Joseph R.
Published: March 2023

PDF - 116K, H&E and Ki67 staining of MMs derived from asbestos-exposed Nf2(+/-);p16/p19(+/-)and WT mice. MMs derived from Nf2 (+/-);p16/p19 (+/-) mice have a higher percentage of Ki67-positive cells than MMs from WT mice.
Data Supplement from Loss of NF1 in Cutaneous Melanoma Is Associated with RAS Activation and MEK Dependence
Authors: Nissan Moriah H. , Pratilas Christine A. , Jones Alexis M. , Ramirez Ricardo , Won Helen , Liu Cailian , Tiwari Shakuntala , Kong Li , Hanrahan Aphrothiti J. , Yao Zhan , Merghoub Taha , Ribas Antoni , Chapman Paul B. , Yaeger Rona , Taylor Barry S. , Schultz Nikolaus , Berger Michael F. , Rosen Neal , Solit David B.
Published: March 2023

Supplementary Tables S1-S2. Cell lines genotyped by Sequenom (S1); MAPK pathway alterations identified in the cohort WT for BRAF/NRAS by Sequenom and NF1 alterations identified in the BRAF/NRAS mutant cohort (S2).
Supplementary Figure Legend from Cell Lineage Tracing Reveals a Biliary Origin of Intrahepatic Cholangiocarcinoma
Authors: Guest Rachel V. , Boulter Luke , Kendall Timothy J. , Minnis-Lyons Sarah E. , Walker Robert , Wigmore Stephen J. , Sansom Owen J. , Forbes Stuart J.
Published: March 2023

PDF file - 54K
Supplementary Figures S1-9 and Tables S1-3 from NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation
Authors: Namiki Takeshi , Yaguchi Tomonori , Nakamura Kenta , Valencia Julio C. , Coelho Sergio G. , Yin Lanlan , Kawaguchi Masakazu , Vieira Wilfred D. , Kaneko Yasuhiko , Tanemura Atsushi , Katayama Ichiro , Yokozeki Hiroo , Kawakami Yutaka , Hearing Vincent J.
Published: March 2023

Supplementary Figures S1-9 and Tables S1-3. Supplementary Figure S1 - Effects of knockdown of NUAK2 on melanoma cells and specificity of the p-AKT antibody. Supplementary Figure S2 - Immunohistochemical analyses of p-Akt and NUAK2 expression in clinical specimens. Supplementary Figure S3 - Kaplan-Meier curves for overall survival of Acral and Non-CSD melanoma patients. Supplementary Figure S4 - Knockdown of NUAK2 induces apoptosis in SM2-1 melanoma cells. Supplementary Figure S5 - Immunohistochemistry showing the expression of p21 following inhibition of the PI3K pathway by LY294002. Supplementary Figure S6 - Schematic diagram of the regulation of the cell cycle machinery by NUAK2 and PI3K pathways. Supplementary Figure S7 - Knockdown of CDK2 by siCDK2 in C32 and mel18 melanoma cells. Supplementary Figure S8 - Immunohistochemical analyses of the expression of CDK2 in clinical specimens. Supplementary Figure S9 - Expression of NUAK2, PTEN, p-Akt, Akt and CDK2, and cell proliferation in various melanoma cell lines treated with Roscovitine. Supplementary Table S1 - Clinical parameters and expressions of CDK2, p-Akt and NUAK2 of 56 acral melanomas and 35 non-CSD melanomas with survival information. Supplementary Table S2 - Genomic status of NUAK2 and PTEN gene in each cell line. Supplementary Table S3 - Expression of p27 and CDK2 in primary melanomas with or without over-expression of NUAK2 and p-Akt.
Supplementary Materials and Methods from CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells
Authors: Lau Wen Min , Teng Eileen , Chong Hui Shan , Lopez Kirsten Anne Pagaduan , Tay Amy Yuh Ling , Salto-Tellez Manuel , Shabbir Asim , So Jimmy Bok Yan , Chan Shing Leng
Published: March 2023

PDF file - 36KB
Supplementary Figure 3 from CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells
Authors: Lau Wen Min , Teng Eileen , Chong Hui Shan , Lopez Kirsten Anne Pagaduan , Tay Amy Yuh Ling , Salto-Tellez Manuel , Shabbir Asim , So Jimmy Bok Yan , Chan Shing Leng
Published: March 2023

PDF file - 130KB, Supplementary Figure S3 shows fractionation of CD44v+ cells for limiting dilution analysis in vitro and in vivo.
Supplementary Table 2 from The Niacin/Butyrate Receptor GPR109A Suppresses Mammary Tumorigenesis by Inhibiting Cell Survival
Authors: Elangovan Selvakumar , Pathania Rajneesh , Ramachandran Sabarish , Ananth Sudha , Padia Ravi N. , Lan Ling , Singh Nagendra , Martin Pamela M. , Hawthorn Lesleyann , Prasad Puttur D. , Ganapathy Vadivel , Thangaraju Muthusamy
Published: March 2023

XLSX file - 27K, Supplementary Table 2 contains genes that are differentially expressed in MB231-pCDH and MB231-GPR109A stable clones without niacin treatment.
Supplementary Figure Legend from A Sequence Polymorphism in miR-608 Predicts Recurrence after Radiotherapy for Nasopharyngeal Carcinoma
Authors: Zheng Jian , Deng Jieqiong , Xiao Mang , Yang Lei , Zhang Liyuan , You Yonghe , Hu Min , Li Na , Wu Hongchun , Li Wei , Lu Jiachun , Zhou Yifeng
Published: March 2023

PDF file - 64K
Supplementary Table 1 from E3 Ubiquitin Ligase HOIP Attenuates Apoptotic Cell Death Induced by Cisplatin
Authors: MacKay Craig , Carroll Eilís , Ibrahim Adel F.M. , Garg Amit , Inman Gareth J. , Hay Ronald T. , Alpi Arno F.
Published: March 2023

XLSX file - 196KB, Excel file with siRNA screen data.
Supplementary Figure 1 from A Sequence Polymorphism in miR-608 Predicts Recurrence after Radiotherapy for Nasopharyngeal Carcinoma
Authors: Zheng Jian , Deng Jieqiong , Xiao Mang , Yang Lei , Zhang Liyuan , You Yonghe , Hu Min , Li Na , Wu Hongchun , Li Wei , Lu Jiachun , Zhou Yifeng
Published: March 2023

PDF file - 3272K, Kaplan-Meier TTR curves of patients with NPC receiving chemotherapy by genotypes of miRNA-608 rs4919510C>G.
Supplementary Table 1 from Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
Authors: Nagathihalli Nagaraj S. , Beesetty Yugandhar , Lee Wooin , Washington M. Kay , Chen Xi , Lockhart A. Craig , Merchant Nipun B.
Published: March 2023

PDF file - 27KB, Sequences of primers used in this study.
Supplementary Figure 8 from Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
Authors: Nagathihalli Nagaraj S. , Beesetty Yugandhar , Lee Wooin , Washington M. Kay , Chen Xi , Lockhart A. Craig , Merchant Nipun B.
Published: March 2023

PDF file - 104KB, EGFR inhibition in combination with TGR5 silencing decreases STAT3 phosphorylation and cell proliferation.
Supplementary Table 2 from The CXCL7/CXCR1/2 Axis Is a Key Driver in the Growth of Clear Cell Renal Cell Carcinoma
Authors: Grépin Renaud , Guyot Mélanie , Giuliano Sandy , Boncompagni Marina , Ambrosetti Damien , Chamorey Emmanuel , Scoazec Jean-Yves , Negrier Sylvie , Simonnet Hélène , Pagès Gilles
Published: March 2023

PDF file - 48K, Clinical and biological parameters and multivariate analysis of patients.
Supplementary Table 1 from The CXCL7/CXCR1/2 Axis Is a Key Driver in the Growth of Clear Cell Renal Cell Carcinoma
Authors: Grépin Renaud , Guyot Mélanie , Giuliano Sandy , Boncompagni Marina , Ambrosetti Damien , Chamorey Emmanuel , Scoazec Jean-Yves , Negrier Sylvie , Simonnet Hélène , Pagès Gilles
Published: March 2023

PDF file - 54K, Clinical and biological parameters and univariate analysis of patients.
Supplementary Methods from Cyclin E1 Deregulation Occurs Early in Secretory Cell Transformation to Promote Formation of Fallopian Tube–Derived High-Grade Serous Ovarian Cancers
Authors: Karst Alison M. , Jones Paul M. , Vena Natalie , Ligon Azra H. , Liu Joyce F. , Hirsch Michelle S. , Etemadmoghadam Dariush , Bowtell David D.L. , Drapkin Ronny
Published: March 2023

PDF file - 75K, FISH (fluorescence in situ hybridization) analysis of TMA and Western blot analysis.
Supplementary Figure Legend from The CXCL7/CXCR1/2 Axis Is a Key Driver in the Growth of Clear Cell Renal Cell Carcinoma
Authors: Grépin Renaud , Guyot Mélanie , Giuliano Sandy , Boncompagni Marina , Ambrosetti Damien , Chamorey Emmanuel , Scoazec Jean-Yves , Negrier Sylvie , Simonnet Hélène , Pagès Gilles
Published: March 2023

PDF file - 93K
Supplementary Table 2 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Authors: Gomez German G. , Volinia Stefano , Croce Carlo M. , Zanca Ciro , Li Ming , Emnett Ryan , Gutmann David H. , Brennan Cameron W. , Furnari Frank B. , Cavenee Webster K.
Published: March 2023

PDF file - 58KB, Relative expression levels of primary human miR-9 transcripts in normal brain and glioma cells.
Supplementary Figure 3 from Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis
Authors: Kim Seaho , Yao Jiahong , Suyama Kimita , Qian Xia , Qian Bin-Zhi , Bandyopadhyay Sanmay , Loudig Olivier , De Leon-Rodriguez Carlos , Zhou Zhen Ni , Segall Jeffrey , Macian Fernando , Norton Larry , Hazan Rachel B.
Published: March 2023

PDF file - 97KB, Supplementary Fig. S3. FGFR controls Slug expression independently of ERK or AKT activation.
Supplementary Figure Legends from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Authors: Gomez German G. , Volinia Stefano , Croce Carlo M. , Zanca Ciro , Li Ming , Emnett Ryan , Gutmann David H. , Brennan Cameron W. , Furnari Frank B. , Cavenee Webster K.
Published: March 2023

PDF file - 88KB
Supplementary Figure 2 from Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis
Authors: Kim Seaho , Yao Jiahong , Suyama Kimita , Qian Xia , Qian Bin-Zhi , Bandyopadhyay Sanmay , Loudig Olivier , De Leon-Rodriguez Carlos , Zhou Zhen Ni , Segall Jeffrey , Macian Fernando , Norton Larry , Hazan Rachel B.
Published: March 2023

PDF file - 63KB, Supplementary Fig. S2. Slug knockdown does not affect cell migration or invasion in PyMT-N-cad cells.
Supplementary Figure 5 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Authors: Gomez German G. , Volinia Stefano , Croce Carlo M. , Zanca Ciro , Li Ming , Emnett Ryan , Gutmann David H. , Brennan Cameron W. , Furnari Frank B. , Cavenee Webster K.
Published: March 2023

PDF file - 48KB, Silencing FOXP1 inhibits the growth of U87deltaEGFR tumors.
Supplementary Figure 4 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Authors: Gomez German G. , Volinia Stefano , Croce Carlo M. , Zanca Ciro , Li Ming , Emnett Ryan , Gutmann David H. , Brennan Cameron W. , Furnari Frank B. , Cavenee Webster K.
Published: March 2023

PDF file - 49KB, Silencing the pri-miR-9-2 host gene downregulates miR-9 and increases U87DK tumor growth.
Supplementary Figure 3 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Authors: Gomez German G. , Volinia Stefano , Croce Carlo M. , Zanca Ciro , Li Ming , Emnett Ryan , Gutmann David H. , Brennan Cameron W. , Furnari Frank B. , Cavenee Webster K.
Published: March 2023

PDF file - 66KB, FOXP4, a putative miR-9 target, shows similar expression in cells with low and high miR-9 expression.
Supplementary Materials and Methods and Figures 1 - 3 from Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma
Authors: Favaro Rebecca , Appolloni Irene , Pellegatta Serena , Sanga Alexandra Badiola , Pagella Pierfrancesco , Gambini Eleonora , Pisati Federica , Ottolenghi Sergio , Foti Maria , Finocchiaro Gaetano , Malatesta Paolo , Nicolis Silvia K.
Published: March 2023

PDF file - 454KB, Supplementary Figure 1: Sox2 expression in tumors analyzed by qRT-PCR. Supplementary Figure 2: SOX2 peptides are able to induce a specific anti-tumor immune response in the peripheral and local immune effector cells. Supplementary Figure 3: Sox2-deleted cells expressing differentiation markers in transplantated brain.
Supplementary Figure 1 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Authors: Gomez German G. , Volinia Stefano , Croce Carlo M. , Zanca Ciro , Li Ming , Emnett Ryan , Gutmann David H. , Brennan Cameron W. , Furnari Frank B. , Cavenee Webster K.
Published: March 2023

PDF file - 30KB, Exogenous growth factors do not modulate miR-9 expression.
Supplementary Figure 1 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Authors: Skrypnyk Nataliya , Chen Xiwu , Hu Wen , Su Yan , Mont Stacey , Yang Shilin , Gangadhariah Mahesha , Wei Shouzuo , Falck John R. , Jat Jawahar Lal , Zent Roy , Capdevila Jorge H. , Pozzi Ambra
Published: March 2023

PDF file - 24K, Analysis of p60.5 and KrasLA2 tumor cells.
Data Supplement from High-Throughput Time-Resolved FRET Reveals Akt/PKB Activation as a Poor Prognostic Marker in Breast Cancer
Authors: Veeriah Selvaraju , Leboucher Pierre , de Naurois Julien , Jethwa Nirmal , Nye Emma , Bunting Tamara , Stone Richard , Stamp Gordon , Calleja Véronique , Jeffrey Stefanie S. , Parker Peter J. , Larijani Banafshé
Published: March 2023

Supplementary Figure 1: Specificity of human anti-Akt (panAkt, pT308) antibodies assessed by quantitative Western blot analysis in SKBR3 cells.
Data Supplement from High-Throughput Time-Resolved FRET Reveals Akt/PKB Activation as a Poor Prognostic Marker in Breast Cancer
Authors: Veeriah Selvaraju , Leboucher Pierre , de Naurois Julien , Jethwa Nirmal , Nye Emma , Bunting Tamara , Stone Richard , Stamp Gordon , Calleja Véronique , Jeffrey Stefanie S. , Parker Peter J. , Larijani Banafshé
Published: March 2023

Supplementary Figure 3: Optimization of TSA amplification in MCF7 cells using TSA amplified immunofluorescence assay.
Supplementary Tables 1 - 2 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Authors: Pastille Eva , Bardini Katrin , Fleissner Diana , Adamczyk Alexandra , Frede Annika , Wadwa Munisch , von Smolinski Dorthe , Kasper Stefan , Sparwasser Tim , Gruber Achim D. , Schuler Martin , Sakaguchi Shimon , Roers Axel , Müller Werner , Hansen Wiebke , Buer Jan , Westendorf Astrid M.
Published: March 2023

PDF file - 43K, Supplemental Table 1. Characteristics of colon cancer patients included in the study. Supplemental Table 2. Primers.
Supplementary Figure 4 from The DREAM Complex Mediates GIST Cell Quiescence and Is a Novel Therapeutic Target to Enhance Imatinib-Induced Apoptosis
Authors: Boichuk Sergei , Parry Joshua A. , Makielski Kathleen R. , Litovchick Larisa , Baron Julianne L. , Zewe James P. , Wozniak Agnieszka , Mehalek Keith R. , Korzeniewski Nina , Seneviratne Danushka S. , Schöffski Patrick , Debiec-Rychter Maria , DeCaprio James A. , Duensing Anette
Published: March 2023

PDF file - 1110K, Supplemental Figure 4. Dual siRNA transfection of E2F4/LIN54 leads to an increased apoptotic response after imatinib while single knock-down of DREAM complex subunits does not.
Supplementary Figure S3 from ERBB3-Independent Activation of the PI3K Pathway in EGFR-Mutant Lung Adenocarcinomas
Authors: Song Xiaoling , Fan Pang-Dian , Bantikassegn Amlak , Guha Udayan , Threadgill David W. , Varmus Harold , Politi Katerina
Published: March 2023

Supplementary Figure S3. Intact signaling in lung tumors deficient for ERBB3.
Supplementary Figure S2 from ERBB3-Independent Activation of the PI3K Pathway in EGFR-Mutant Lung Adenocarcinomas
Authors: Song Xiaoling , Fan Pang-Dian , Bantikassegn Amlak , Guha Udayan , Threadgill David W. , Varmus Harold , Politi Katerina
Published: March 2023

Supplementary Figure S2. Development of lung adenocarcinomas in mice lacking ERBB3.
Supplementary Table 5 from Genetic and Phenotypic Diversity in Breast Tumor Metastases
Authors: Almendro Vanessa , Kim Hee Jung , Cheng Yu-Kang , Gönen Mithat , Itzkovitz Shalev , Argani Pedram , van Oudenaarden Alexander , Sukumar Saraswati , Michor Franziska , Polyak Kornelia
Published: March 2023

XLSX file - 32K, Shannon and Simpson's index for each tumor and each probe based on BAC, CEP, BAC/CEP and unique counts.
Supplementary Figure Legends from ERBB3-Independent Activation of the PI3K Pathway in EGFR-Mutant Lung Adenocarcinomas
Authors: Song Xiaoling , Fan Pang-Dian , Bantikassegn Amlak , Guha Udayan , Threadgill David W. , Varmus Harold , Politi Katerina
Published: March 2023

Legends for Supplementary Figures S1-S7.
Supplementary Table 4 from Genetic and Phenotypic Diversity in Breast Tumor Metastases
Authors: Almendro Vanessa , Kim Hee Jung , Cheng Yu-Kang , Gönen Mithat , Itzkovitz Shalev , Argani Pedram , van Oudenaarden Alexander , Sukumar Saraswati , Michor Franziska , Polyak Kornelia
Published: March 2023

XLSX file - 86K, Shannon and Simpson's index for each cell type based on BAC, CEP, BAC/CEP and unique counts.
Supplementary Figure Legends from Genetic and Phenotypic Diversity in Breast Tumor Metastases
Authors: Almendro Vanessa , Kim Hee Jung , Cheng Yu-Kang , Gönen Mithat , Itzkovitz Shalev , Argani Pedram , van Oudenaarden Alexander , Sukumar Saraswati , Michor Franziska , Polyak Kornelia
Published: March 2023

PDF file - 48K
Data Supplement from Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development
Authors: Giammanco Antonina , Blanc Valerie , Montenegro Grace , Klos Coen , Xie Yan , Kennedy Susan , Luo Jianyang , Chang Sung-Hee , Hla Timothy , Nalbantoglu ILKe , Dharmarajan Sekhar , Davidson Nicholas O.
Published: March 2023

Supplemental Figure S1. Perinatal deletion of intestinal HuR in the Apc min/+ background does not alter tumorigenesis.
Supplemental Figure 7 from Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells
Authors: Candas Demet , Lu Chung-Ling , Fan Ming , Chuang Frank Y.S. , Sweeney Colleen , Borowsky Alexander D. , Li Jian Jian
Published: March 2023

Supplemental Figure 7. Inhibition of mitochondrial localization of MKP1 upon HER2 inhibitor, Lapatinib, treatment in MCF7/C6 cells
Supplemental Figure 5 from Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells
Authors: Candas Demet , Lu Chung-Ling , Fan Ming , Chuang Frank Y.S. , Sweeney Colleen , Borowsky Alexander D. , Li Jian Jian
Published: March 2023

Supplemental Figure 5. Cell viability following MKP1 inhibitior, Sanguinarine, treatment in MCF7/C6 cells
Supplemental Figure 2 from Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells
Authors: Candas Demet , Lu Chung-Ling , Fan Ming , Chuang Frank Y.S. , Sweeney Colleen , Borowsky Alexander D. , Li Jian Jian
Published: March 2023

Supplemental Figure 2. The inhibition of ERK phosphorylation by U0126
Figures S1-S3 from TGFβ Receptor 1: An Immune Susceptibility Gene in HPV-Associated Cancer
Authors: Levovitz Chaya , Chen Dan , Ivansson Emma , Gyllensten Ulf , Finnigan John P. , Alshawish Sara , Zhang Weijia , Schadt Eric E. , Posner Marshal R. , Genden Eric M. , Boffetta Paolo , Sikora Andrew G.
Published: March 2023

Figures S1-S3. All supplementary figures are included in this file. Descriptions are given for each figure on the image itself. Supplementary Figure S1: OPC GWAS analysis Supplementary Figure S2: Comparative scatter plot by HNSCC tumor site vs HPV E6 serology Supplementary Figure S3: DAPPLE randomization and extended boundary analysis
Supplemental Methods from Metabolic Vulnerabilities in Endometrial Cancer
Authors: Byrne Frances L. , Poon Ivan K.H. , Modesitt Susan C. , Tomsig Jose L. , Chow Jenny D.Y. , Healy Marin E. , Baker William D. , Atkins Kristen A. , Lancaster Johnathan M. , Marchion Douglas C. , Moley Kelle H. , Ravichandran Kodi S. , Slack-Davis Jill K. , Hoehn Kyle L.
Published: March 2023

Supplemental Methods. Includes more detailed methods for the main manuscript and additional supplemental methods including Cell Culture, Sources of drugs/radioactive tracers,Targets/functions of metabolic drugs and antioxidants, Preparation of protein lysates, Nutrient metabolism assays, qPCR primer sequences, Cytotoxicity assays, Cell doubling times, Cellular ATP levels, ROS assays, Mass spectrometry of Acetyl-CoA and Pyruvylated-CoA, and Supplemental References.
Supplemental Figures S1-8 from Metabolic Vulnerabilities in Endometrial Cancer
Authors: Byrne Frances L. , Poon Ivan K.H. , Modesitt Susan C. , Tomsig Jose L. , Chow Jenny D.Y. , Healy Marin E. , Baker William D. , Atkins Kristen A. , Lancaster Johnathan M. , Marchion Douglas C. , Moley Kelle H. , Ravichandran Kodi S. , Slack-Davis Jill K. , Hoehn Kyle L.
Published: March 2023

Supplemental Figures S1-8. Figure S1: Protein expression in human endometrial tissue. Figure S2: GLUT6 expression in human endometrial tissue Figure S3: Correlation between metabolic protein expression and metabolism in endometrial cells. Figure S4: GLUT6 knockdown in endometrial cancer cells induces cell death. Figure S5: Correlation analyses for drug sensitivity. Figure S6: Precursor Ion Scan of Pyruvylated-CoA. Figure S7: Antioxidants (without thiol groups) could not protect against 3-bromopyruvate-mediated cell death. Figure S8: ATP levels and cell death induced by 3-bromopyruvate.
Data Supplement from TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy
Authors: Xie Jia-Ming , Li Bin , Yu Hong-Pei , Gao Quan-Geng , Li Wei , Wu Hao-Rong , Qin Zheng-Hong
Published: March 2023

Supplemental Figure S2. TIGAR expression was regulated by TP53 in HepG2 cells.
Data Supplement from TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy
Authors: Xie Jia-Ming , Li Bin , Yu Hong-Pei , Gao Quan-Geng , Li Wei , Wu Hao-Rong , Qin Zheng-Hong
Published: March 2023

Supplemental Figure S5. NAC reduced TIGAR knockdown-induced alterations in ROS levels, GSH/GSSH ratio, NADPH levels and cell survival after epirubicin treatment.
Supplementary Figure 2 from Function-Blocking ERBB3 Antibody Inhibits the Adaptive Response to RAF Inhibitor
Authors: Kugel Curtis H. , Hartsough Edward J. , Davies Michael A. , Setiady Yulius Y. , Aplin Andrew E.
Published: March 2023

PDF file - 232K, Additional Cell lines.
Data Supplement from TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy
Authors: Xie Jia-Ming , Li Bin , Yu Hong-Pei , Gao Quan-Geng , Li Wei , Wu Hao-Rong , Qin Zheng-Hong
Published: March 2023

Legends for Supplemental Figures S1-S5
Supplementary Materials and Methods from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer
Authors: Gallot Yann S. , Durieux Anne-Cécile , Castells Josiane , Desgeorges Marine M. , Vernus Barbara , Plantureux Léa , Rémond Didier , Jahnke Vanessa E. , Lefai Etienne , Dardevet Dominique , Nemoz Georges , Schaeffer Laurent , Bonnieu Anne , Freyssenet Damien G.
Published: March 2023

Description of additional methods and procedures used in the study.
Supplemental Methods and References,Supplementary Figures S1-S3, and Supplementary Table S1 from RHPN2 Drives Mesenchymal Transformation in Malignant Glioma by Triggering RhoA Activation
Authors: Danussi Carla , Akavia Uri David , Niola Francesco , Jovic Andreja , Lasorella Anna , Pe'er Dana , Iavarone Antonio
Published: March 2023

Supplemental Methods and References. Figure S1. Illustration of Module generation Figure S2. CNV and Expression of RHPN2 in GBM samples from TCGA and Rembrandt databases. Figure S3. Western Blot and qPCR of RHPN2 in different cell lines. Table S1. List of Primers
Supplementary Figure 2 from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: March 2023

Supplementary Figure 2. This figure shows additional characterization of global nucleosomal positioning changes in Brg1 KD cell lines.
Supplementary Figures S1-S7 from Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b
Authors: Shiah Shine-Gwo , Hsiao Jenn-Ren , Chang Wei-Min , Chen Ya-Wen , Jin Ying-Tai , Wong Tung-Yiu , Huang Jehn-Shyun , Tsai Sen-Tien , Hsu Yuan-Ming , Chou Sung-Tau , Yen Yi-Chen , Jiang Shih Sheng , Shieh Yi-Shing , Chang I-Shou , Hsiao Michael , Chang Jang-Yang
Published: March 2023

Supplementary Figures S1-S7. Supplementary Figure S1: Genome-wide profiling of chromosome 14q32.2 miRNA on OSCC tissues. Supplementary Figure S2: Mi-RNA level in miR-PM overexpressed OEC-M1 and SCC-15 cells. Supplementary Figure S3: Effect of miR-329 and miR-410 on Wnt/ÃŽÂ²-catenin signaling pathway. Supplementary Figure S4: The effects of miR-329 and miR-410 on tumor cell proliferation. Supplementary Figure S5: Expression level of miRNA in xenograft tumor tissue. Supplementary Figure S6: Effects of miR-329 and -410 on tumorigenicity. Supplementary Figure S7: Effects of arecoline on Wnt/ÃŽÂ²-catenin signaling pathway.
Supplementary Figures S1-S10 from Cellular Factors Promoting Resistance to Effective Treatment of Glioma with Oncolytic Myxoma Virus
Authors: Zemp Franz J. , McKenzie Brienne A. , Lun Xueqing , Reilly Karlyne M. , McFadden Grant , Yong V. Wee , Forsyth Peter A.
Published: March 2023

Immunophenotyping of the K1492 glioma microenvironment in response to sterile injury (S1); Immunophenotyping of the K1492 glioma microenvironment after Myxoma virus treatment (S2); Virus infected areas of K1492 tumours are accompanied by polymorphonuclear cell infiltration (S3); K1861 and Spontaneous NPcis gliomas in C57Bl/6 mice have significant microglia and/or GIM recruitment (S4); Non-tumour bearing CCR2-deficient animals are only slightly impaired in clearing MYXV (S5); CCR2-deficient mice have an exaggerated recruitment of NK and T cells to the K1492 glioma in response to Myxoma treatment (S6); Minocycline administration mimics CCR2-null viral clearance kinetics but does not result in a survival advantage (S7); K1492 tumours in IL2Rγ mice are significantly depleted of NK and T cell populations (S8); Non-tumour bearing IL2Rγ-deficient animals are impaired in clearing MYXV (S9); Single low-dose cyclophosphamide combined with Myxoma treatment did result in improved treatment efficacy or viral infection (S10).
Supplemental Figures S1-S12 from CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene–Transformed Metastatic Prostate Cancer Cell Lines
Authors: Sicoli Daniela , Jiao Xuanmao , Ju Xiaoming , Velasco-Velazquez Marco , Ertel Adam , Addya Sankar , Li Zhiping , Andò Sebastiano , Fatatis Alessandro , Paudyal Bishnuhari , Cristofanilli Massimo , Thakur Mathew L. , Lisanti Michael P. , Pestell Richard G.
Published: March 2023

Supplemental Figures S1-S12. Supplement 1. High resolution images of normal prostate and v-Src-PEC tumor Supplement 2. AR, CK5 and CK8 abundances in cultured v-Src-PECs compared with primary cultured normal PECs detected by western-blot. Supplement 3. High resolution images of v-Src-PEC bone metastasis tumor and adjacent bone marrow Supplement 4. Kegg-pathway analysis of up-regulated genes in v-Src-PEC tumor vs normal prostate Supplement 5. High resolution gene expression profile comparing normal FVB murine prostate epithelial cells Supplement 6. Validation of CCR5 expression by qtPCR in v-Src-PEC tumors derived by subcutaneous injection compared with normal prostate Supplement 7. CCR5 expression in public available database Supplement 8. FACS analysis of CCR5 positive population in v-Src-PECs Supplement 9. High resolution image of immunohistochemical staining for CCR5 in v-Src-PEC metastasis in bone which showed in figure 5 Supplement 10. High resolution image of (A-D) histological images Supplement 11. CK5 (A) and CK8 (C) immunohistochemical staining in the prostate of castrated mice vs normal mice. Supplement 12. CCR5 IHC staining in bone metastasis v-Src-PEC tumor.
Data Supplement from IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Authors: Venmar Katherine T. , Carter Kathy J. , Hwang Daniel G. , Dozier E. Ashley , Fingleton Barbara
Published: March 2023

Supplemental Figure 1: Macroscopic analysis of metastatic mammary tumor growth
Data Supplement from A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer
Authors: Zhao Yu , Yang Yihua , Trovik Jone , Sun Kun , Zhou Liang , Jiang Peiyong , Lau Tat-San , Hoivik Erling A. , Salvesen Helga B. , Sun Hao , Wang Huating
Published: March 2023

Supplemental Tables S1-S5. Characteristics of the 45 normal tissues included in the PCDH10 expression analysis (S1); Characteristics of the 9 normal tissues included in the MALAT1 expression by ISH analysis (S2); Characteristics at primary treatment of 142 endometrial cancer patients from MoMaTEC* trial included in the MALAT1 investigation (S3); PCDH10 RNA expression from 142 prospectively collected endometrial cancer tumors, 19 metastatic lesions and 18 endometrial hyperplasia samples in relation to clinicopathologic data (S4); Oligos used for qRT-PCR, ChIP-PCR, Cloning and Bisulfate genomic sequencing (S5).
Data Supplement from IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Authors: Venmar Katherine T. , Carter Kathy J. , Hwang Daniel G. , Dozier E. Ashley , Fingleton Barbara
Published: March 2023

Supplemental Figure 4: Immunohistochemical staining of immune infiltrates in 4T1 metastases
Supplementary Figure S7 from Selective In Vivo Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe
Authors: Stangl Stefan , Varga Julia , Freysoldt Bianca , Trajkovic-Arsic Marija , Siveke Jens T. , Greten Florian R. , Ntziachristos Vasilis , Multhoff Gabriele
Published: March 2023

Supplemental Figures 7A,B: True color images and TPP[cy5.5]-derived fluorescence signals of tumor-bearing mice. Figure S7A: dorsal views of CT26 Tumors (s.c.). Figure 7B: ventral views of 4T1 tumors (o.t.)in mice.
Supplementary Figure S6 from Selective In Vivo Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe
Authors: Stangl Stefan , Varga Julia , Freysoldt Bianca , Trajkovic-Arsic Marija , Siveke Jens T. , Greten Florian R. , Ntziachristos Vasilis , Multhoff Gabriele
Published: March 2023

Supplemental Figure S6: Regression analysis of tissue-mimicking concentration-standard gel cubes.
Supplementary Table 2 from A Regulatory Loop Involving miR-22, Sp1, and c-Myc Modulates CD147 Expression in Breast Cancer Invasion and Metastasis
Authors: Kong Ling-Min , Liao Cheng-Gong , Zhang Yang , Xu Jing , Li Yu , Huang Wan , Zhang Yi , Bian Huijie , Chen Zhi-Nan
Published: March 2023

PDF file - 96K, Clinicopathologic characteristics of miR-22 expression in breast cancer patients.
Supplementary Figure 3 from A Regulatory Loop Involving miR-22, Sp1, and c-Myc Modulates CD147 Expression in Breast Cancer Invasion and Metastasis
Authors: Kong Ling-Min , Liao Cheng-Gong , Zhang Yang , Xu Jing , Li Yu , Huang Wan , Zhang Yi , Bian Huijie , Chen Zhi-Nan
Published: March 2023

PDF file - 17K, Western blot assays the effect of Sp3 and Sp4 on CD147 protein expression.
Supplementary Figures 1 - 6 from Mycoplasma Hyorhinis Infection Promotes NF-κB–Dependent Migration of Gastric Cancer Cells
Authors: Duan Hongying , Chen Ling , Qu Like , Yang Hua , Song Sonya Wei , Han Yong , Ye Meihua , Chen Wanyuan , He Xianglei , Shou Chengchao
Published: March 2023

Figure S1. Expression of p37 in gastric cancer tissues. Figure S2. p37 mediates M. hyorhinis infection. Figure S3. Alignment of N-terminal of p37 with proteins from other mycoplasma species. Figure S4. ANXA2 is essential for M. hyorhinis and p37 binding to cells. Figure S5. M. hyorhinis regulates ANXA2 localization in an EGFR-dependent manner. Figure S6. Gene Ontology (GO) analysis of genechip results indicate the activation of NF-kB signaling.
Supplementary Table 2 from Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Authors: Ostenfeld Marie Stampe , Jeppesen Dennis K. , Laurberg Jens R. , Boysen Anders T. , Bramsen Jesper B. , Primdal-Bengtson Bjarke , Hendrix An , Lamy Philippe , Dagnaes-Hansen Frederik , Rasmussen Mads H. , Bui Khan H. , Fristrup Niels , Christensen Erik I. , Nordentoft Iver , Morth Jens P. , Jensen Jørgen B. , Pedersen Jakob S. , Beck Martin , Theodorescu Dan , Borre Michael , Howard Kenneth A. , Dyrskjøt Lars , Ørntoft Torben Falck
Published: March 2023

Lists of i) top30 exocytosed miRNAs and ii) cellular-retained miRNAs.
Supplementary Figure 2 from Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Authors: Ostenfeld Marie Stampe , Jeppesen Dennis K. , Laurberg Jens R. , Boysen Anders T. , Bramsen Jesper B. , Primdal-Bengtson Bjarke , Hendrix An , Lamy Philippe , Dagnaes-Hansen Frederik , Rasmussen Mads H. , Bui Khan H. , Fristrup Niels , Christensen Erik I. , Nordentoft Iver , Morth Jens P. , Jensen Jørgen B. , Pedersen Jakob S. , Beck Martin , Theodorescu Dan , Borre Michael , Howard Kenneth A. , Dyrskjøt Lars , Ørntoft Torben Falck
Published: March 2023

Characterization of cells upon miRNA overexpression and knockdown.
Supplementary Figure S4 from CtBP2 Modulates the Androgen Receptor to Promote Prostate Cancer Progression
Authors: Takayama Ken-ichi , Suzuki Takashi , Fujimura Tetsuya , Urano Tomohiko , Takahashi Satoru , Homma Yukio , Inoue Satoshi
Published: March 2023

Supplementary Figure S4. ChIP-seq views of representative AR binding genes.
Supplementary Figure 4 from Molecular Modulation of Estrogen-Induced Apoptosis by Synthetic Progestins in Hormone Replacement Therapy: An Insight into the Women's Health Initiative Study
Authors: Sweeney Elizabeth E. , Fan Ping , Jordan V. Craig
Published: March 2023

Supplementary Figure 4. MCF-7:WS8 cells were treated with vehicle, 1nM E2, or 10nM, 100nM or 1µM concentrations of Dex, MPA, or NETA for 24 hours. PR mRNA expression was quantified by RT-PCR. 36B4 was used as an internal control. Means represent three samples in triplicate.
SI materials and methods from mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress
Authors: Li Jing , Shin Sejeong , Sun Yang , Yoon Sang-Oh , Li Chenggang , Zhang Erik , Yu Jane , Zhang Jianming , Blenis John
Published: March 2023

additional information of materials and methods
Supplementary Figure 3 from Targeting of miR34a–NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance
Authors: Park Eun Young , Chang EunSun , Lee Eun Ji , Lee Hyun-Woo , Kang Hyeok-Gu , Chun Kyung-Hee , Woo Yu Mi , Kong Hyun Kyung , Ko Je Yeong , Suzuki Hiromu , Song Erwei , Park Jong Hoon
Published: March 2023

Supplementary Figure 3. The relationship between Notch1 and miR-34 family members.
Supplementary Video 2 from Deubiquitination of γ-Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells
Authors: Zarrizi Reihaneh , Menard Julien Albert , Belting Mattias , Massoumi Ramin
Published: March 2023

Live cell microscopy of MDA-MB-468 inducibly expressing empty expression plasmid and transiently transfected with H2B-GFP. The movie shows chromosome lagging.
Supplemental Figure Legends from Targeting Cancer Stem–like Cells as an Approach to Defeating Cellular Heterogeneity in Ewing Sarcoma
Authors: Cornaz-Buros Sandrine , Riggi Nicolo , DeVito Claudio , Sarre Alexandre , Letovanec Igor , Provero Paolo , Stamenkovic Ivan
Published: March 2023

Supplemental Figure Legends. Legends for Supplemental Figures S1-S2.
Supplementary Figure Legends from Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes
Authors: Kanterman Julia , Sade-Feldman Moshe , Biton Moshe , Ish-Shalom Eliran , Lasry Audrey , Goldshtein Aviya , Hubert Ayala , Baniyash Michal
Published: March 2023

Legend for Supplementary Figures S1-S8.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: March 2023

Description of additional methods and procedures used in the study.
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Authors: von Roemeling Christina A. , Radisky Derek C. , Marlow Laura A. , Cooper Simon J. , Grebe Stefan K. , Anastasiadis Panagiotis Z. , Tun Han W. , Copland John A.
Published: March 2023

Supplementary Figure 4. Measurement of intracellular calcium influx into (A) empty vector or (B) GluR4 transfected Caki1 cells treated with 1ng/µL R-NPTX2 and DMSO or CFM-2 (10µM) over time using the cell permeable fluorescently labeled calcium indicator Calcium GreenTM-1, AM. Results are calculated as change in fluorescence over time (min). (*) Denotes significant change in fluorescence as compared to DMSO control per time point, and (**) denotes a significant change between R-NPTX2 +/- CFM-2 treated cells. (C) Intracellular Ca2+ levels of NPTX2 and NPTX2-GluR4 transfected Caki1 cells pretreated for 1 hour with DMSO or specified doses of CFM-2. (*) Denotes a significant change in fluorescence of NPTX2 and NPTX2-GluR4 as compared to EV control, and (**) indicates significant changes in fluorescence between DMSO and CFM-2 treated groups
Supplementary Tables S1-S2 from Paclitaxel Therapy Promotes Breast Cancer Metastasis in a TLR4-Dependent Manner
Authors: Volk-Draper Lisa , Hall Kelly , Griggs Caitlin , Rajput Sandeep , Kohio Pascaline , DeNardo David , Ran Sophia
Published: March 2023

RT-qPCR Primers (S1); Effect of TLR4 on incidence and metastatic burden in nab-PXL treated and untreated mice (S2).
Figure S2 from Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Authors: Tao Shasha , Wang Shue , Moghaddam Seyed Javad , Ooi Aikseng , Chapman Eli , Wong Pak K. , Zhang Donna D.
Published: March 2023

Figure S2. The protein levels of NRF2 and the phosphorylated form of the extracellular signal-regulated kinase (p-ERK; a readout of KRAS activation) in several lung cell lines. Cell lysates were subjected to immunoblot analysis with anti-Nrf2, anti-ERK and an antibody specific for phosphorylated ERK.
Data Supplement from TRIB1 Supports Prostate Tumorigenesis and Tumor-Propagating Cell Survival by Regulation of Endoplasmic Reticulum Chaperone Expression
Authors: Mashima Tetsuo , Soma-Nagae Taeko , Migita Toshiro , Kinoshita Ryoko , Iwamoto Atsushi , Yuasa Takeshi , Yonese Junji , Ishikawa Yuichi , Seimiya Hiroyuki
Published: March 2023

Supplementary Table 1 shows gene ontology analysis on the prostate cancer spheroid cells.
List of Speakers from Mouse Models of Human Cancer
Authors: Böck Barbara C. , Stein Ulrike , Schmitt Clemens A. , Augustin Hellmut G.
Published: March 2023

List of Speakers
Supplemental Figure S2 from Aurora-A Inhibition Offers a Novel Therapy Effective against Intracranial Glioblastoma
Authors: Van Brocklyn James R. , Wojton Jeffrey , Meisen Walter H. , Kellough David A. , Ecsedy Jeffery A. , Kaur Balveen , Lehman Norman L.
Published: March 2023

Morphologic changes of GB neurosphere cells treated with different Aurora-A inhibitors.
SuppFigure4 from Changes in Pyruvate Metabolism Detected by Magnetic Resonance Imaging Are Linked to DNA Damage and Serve as a Sensor of Temozolomide Response in Glioblastoma Cells
Authors: Park Ilwoo , Mukherjee Joydeep , Ito Motokazu , Chaumeil Myriam M. , Jalbert Llewellyn E. , Gaensler Karin , Ronen Sabrina M. , Nelson Sarah J. , Pieper Russell O.
Published: March 2023

SuppFigure4. TMZ exposure (100 μM, 3 hrs) significantly alters intracellular concentrations of pyruvate and lactate (*, p<0.05) in MGMT deficient U87 cells and BG-treated, MGMT-depleted G55 cells.
Supplementary Materials and Methods, Supplementary Tables 1 through 10, and Supplementary Figures 1 through 20 from MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity
Authors: Chen Yi-Fen , Yang Cheng-Chieh , Kao Shou-Yen , Liu Chung-Ji , Lin Shu-Chun , Chang Kuo-Wei
Published: March 2023

Supplementary Materials and Methods. Table S1. Cell cultivation conditions. Table S2. siRNAs used in the present study. Table S3. TaqMan assay probes used in the present study. Table S4. Primers used in the present study. Table S5. shRNA clones used in the present study. Table S6. Paired OSCC samples for qRT-PCR and Western blot analysis. Table S7. OSCC samples in TMA for IHC and ISH analysis. Table S8. Primary antibodies or associated reagents used in the present study. Table S9. The complimentarity between miR-211 and the 3â€™UTR of TCF12 gene. Table S10. Jaspar prediction scores. Fig S1. Genotyping of K14-EGFP-miR-211 transgenic mouse model. Fig S2. GFP immunoreactivity and thickness in squamous epithelium. Fig S3. Immunohistochemistry of the cell proliferation and survival proteins in tongue epithelium. Fig S4. Induction of mouse esophageal tumorigenesis by 4NQO. Fig. S5. Representative histopathological sections of orthotopic xenografts and neck lymph nodes. Fig. S6. Analysis of pri-miR-211 expression in OSCC cells. Fig. S7. miR-211 staining and TCF12 immunoreactivity in mouse tongue tissues. Fig. S8. Analysis of TCF12 protein in subcellular fractions in FaDu cells. Fig. S9. Phenotypic analysis of OECM1 cell with TCF12 expression. Fig. S10. Correlation between miR-211 expression and TCF12 mRNA expression in OSCC tumors. Fig. S11. miR-211 staining and TCF12 immunoreactivity in OSCC. Fig. S12. TCF12 immunoreactivity in mouse multistep carcinogenesis. Fig. S13. Color diagram of Fig. 4A, a. Fig S14. Analysis of TCF12 associated biological processes and gene interaction networks. Fig. S15. Prediction of the potential regulation of TCF12 on the promoter activity of downstream genes using Jasper software. Fig. S16. qRT-PCR analysis to confirm the regulation of TCF12 on downstream genes across different OSCC cells. Fig. S17. Correlation between the expression of TCF12 and FAM213A in database. Fig. S18. FAM213A immunoreactivity. Fig. S19. Color diagram of Fig. 6D. Fig. S20. Kaplan-Meier survival analysis.
Supplemental Figures S1-S12 from Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer
Authors: Geng Chuandong , Rajapakshe Kimal , Shah Shrijal S. , Shou John , Eedunuri Vijay Kumar , Foley Christopher , Fiskus Warren , Rajendran Mahitha , Chew Sue Anne , Zimmermann Martin , Bond Richard , He Bin , Coarfa Cristian , Mitsiades Nicholas
Published: March 2023

Reciprocal gene set enrichment analysis reveals that SPOP F102C, F133V, and F133L mutants have similar effects on the PC transcriptome (S1); AR Activity Score of PC cells expressing wt or mutant SPOPs (S2); Effects of wt-SPOP and PC-associated SPOP mutants on mRNA expression of AR target genes in Abl PC cells (S3); The transcriptomic response induced by mt-SPOPs in PC cells enriches strongly for target genes of AR antagonists (S4); The impact of SPOP on AR protein levels in Abl cells is post-translational (S5); Wt-SPOP, but not its PC-associated mutants, suppresses AR protein levels in androgen-dependent PC cells (S6); The interaction between SPOP-wt and AR can occur even in the absence of SRC-3 protein (S7); Interaction and binding of SPOP-wt to AR is mediated by an SBC motif (a.a.646-a.a.651) located in the Hinge Region of the AR protein (S8); Endogenous SPOP interacts with and regulates the expression levels of the AR protein in PC cells (S9); The impact of SPOP on AR protein levels in 22Rv1 cells is post-translational (S10); Growth promoting effect of PC-associated SPOP mutants in the context of AR axis inhibition (S11); SPOP gene signature scores in human PC specimens correlate strongly with androgen receptor activity (S12).
Figure S2 from PELP1 Overexpression in the Mouse Mammary Gland Results in the Development of Hyperplasia and Carcinoma
Authors: Cortez Valerie , Samayoa Cathy , Zamora Andrea , Martinez Lizatte , Tekmal Rajeshwar R. , Vadlamudi Ratna K.
Published: March 2023

Figure S2. Representative IHC images showing the status of cyclin D1
Data Supplement from Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2
Authors: Lee Yun-Han , Seo Daekwan , Choi Kyung-Ju , Andersen Jesper B. , Won Min-Ah , Kitade Mitsuteru , Gómez-Quiroz Luis E. , Judge Adam D. , Marquardt Jens U. , Raggi Chiara , Conner Elizabeth A. , MacLachlan Ian , Factor Valentina M. , Thorgeirsson Snorri S.
Published: March 2023

Supplementary Table S1. List of 88 genes commonly deregulated by siRNA-mediated knockdown of HDAC2 in Huh7 and HepG2 cells.
Supplementary Figure S1 from Transcriptional Dynamics in Colorectal Carcinogenesis: New Insights into the Role of c-Myc and miR17 in Benign to Cancer Transformation
Authors: Ben-David Eyal , Bester Assaf C. , Shifman Sagiv , Kerem Batsheva
Published: March 2023

Expression of modules during carcinogenesis.