bluuebunny/crossref_metadata_2025 huggingface dataset:
780-P: Occurrence of Gastrointestinal (GI) Side Effects upon GLP-1 Receptor Agonist (GLP-1RA) Initiation with Concomitant Metformin Use
Authors: KLEIN KLARA R. , CLEMMENSEN KIM K.B. , FONG EDWIN , OLSEN SØREN , ABRAHAMSEN TRINE J. , LINGVAY ILDIKO
Published: June 2023

GI symptoms are common side effects reported with both GLP-1RA and metformin use, yet these agents are often prescribed in combination. GLP-1RA are initiated at low dose and escalated to minimize the occurrence of GI side effects. Still, most treatment related GI adverse events occur during the dose titration period. We evaluated whether concomitant metformin use increases the rate of GI adverse events during the GLP-1RA titration period.

Using data from 4 clinical trials, LEADER (1.8 mg liraglutide), STEP-2 (1/2.4 mg semaglutide), SUSTAIN-6 (0.5/1 mg semaglutide), and PIONEER-6 (14 mg oral semaglutide), we compared the incidence of GI adverse events during the titration period defined as the expected time to steady state of the respective drug (3 weeks-5 months, see table) in participants with and without concomitant metformin use.

Of the 16,996 participants in these trials, 12,928 (76%) were treated with metformin. The percent of participants who developed new or serious GI adverse events during the titration period was similar across those with or without concomitant metformin use in each group (GLP-1RA or placebo) in all trials (Table). The occurrence of individual GI event (nausea, vomiting, diarrhea, and constipation) was also similar (data not shown).

In summary, concomitant metformin use does not increase the occurrence of GI symptoms during early GLP-1RA treatment.

Disclosure

K.R.Klein: None. K.K.B.Clemmensen: Employee; Novo Nordisk A/S, Stock/Shareholder; Novo Nordisk A/S. E.Fong: Employee; Novo Nordisk A/S. S.Olsen: None. T.J.Abrahamsen: Employee; Novo Nordisk A/S, Stock/Shareholder; Novo Nordisk A/S, Genmab A/S. I.Lingvay: Advisory Panel; Novo Nordisk A/S, Lilly Diabetes, Boehringer-Ingelheim, Sanofi, Consultant; Carmot Therapeutics, Inc., Merck Sharp & Dohme Corp., Janssen Scientific Affairs, LLC, Pfizer Inc., Intercept, Intarcia, Valeritas, TargetRWE, Shionogi, Zealand Pharma, Structure, Bayer, Research Support; Novo Nordisk A/S, Boehringer-Ingelheim.
835-P: First-in-Human Duodenal Endoscopic Recellularization via Electroporation Therapy for Type 2 Diabetes—An Interim Report
Authors: YI YUAN CHENG , SARTORETTO ADRIAN , HOLT BRONTE , CAMERON GEORGINA , MARINOS GEORGE , NAPIER-FLOOD FIONA E. , ABU DAYYEH BARHAM K. , O'NEAL DAVID N.
Published: June 2023

Background: We evaluated the feasibility and safety of endoscopic re-cellularization via electroporation therapy (ReCET) (Endogenex. Plymouth, MN) in restoring impaired duodenal signaling adversely impacting glucose control in type 2 diabetes (T2D).

Method: We enrolled 30 adults with T2D: duration ≤10 years; HbA1c 7.5-11.0%; BMI of 24-40 kg/m2; C-peptide ≥333pmol/L; 1-4 non-insulin glucose-lowering medications (GLMs) at stable dose. Post-procedure GLMs were unchanged. Primary endpoint: Device or procedure-related serious adverse events (SAEs). Secondary endpoints: Changes in metabolic parameters at 24W.

Results: The first 12 participants received single energy (Single Tx) then 18 received double energy application (Double Tx) with no device/procedure-related SAEs. Forty-five adverse events were reported in 23/30 participants (sore throat [17/30]; transient diarrhea [9/30]) and 80% were mild.

HbA1c reduction at 24W was greater with double vs. single Tx (p<0.05). For double Tx vs. baseline: FPG was 7.5±1.7 mmol/L vs. 9.8±2.2 mmol/L (p<0.01), HOMA-IR 4.5±3.6 vs. 7.4±3.3 (p<0.01), Time-in-range 79.4±18.8 % vs. 59.0±24.2% (p<0.01), triglyceride 2.0±1.2mmol/L vs. 2.9±1.9mmol/L (P<0.05) and Δweight -5.1%±4.1% (p<0.01).

Conclusions: Our data suggest that ReCET is safe and associated with clinically meaningful changes in metabolic control in T2D patients on GLMs.

Disclosure

C.Yuan: None. A.Sartoretto: Advisory Panel; Bariatek, Research Support; Endogenex, Erbe Electromedizin GMBH, Speaker's Bureau; Pfizer Inc., Stock/Shareholder; Apollo Endosurgery. B.Holt: None. G.Cameron: None. G.Marinos: None. F.E.Napier-flood: None. B.K.Abu dayyeh: Advisory Panel; Endogenex, Consultant; Apollo Endosurgery, Boston Scientific Corporation, Medtronic, Research Support; USGI, Endogastric Solutions. D.N.O'neal: None.
91-LB: COVALENT-111, a Phase 1/2 Trial of BMF-219, a Covalent Menin Inhibitor, in Patients with Type 2 Diabetes Mellitus—Preliminary Results
Authors: RODRIGUEZ JOSE E. , ABITBOL ALEXANDER , ABUZGAYA FATHI , PEREZ CESAR , MOURYA SANCHITA , MUNNEKE BRIAN , MORRIS STEPHAN W. , BUTLER THOMAS
Published: June 2023

Type 2 Diabetes Mellitus (T2DM) is characterized by impaired glycemic control caused by insulin resistance and progressive beta cell failure. Menin, a scaffold protein, drives beta cell proliferation when inhibited. We have reported BMF-219, an oral covalent menin inhibitor, elicits durable glycemic control following a short treatment in a ZDF Rat model. COVALENT-111, a randomized, double-blind, placebo-controlled study is evaluating BMF-219 in healthy adults and adults with T2DM diagnosed ≤15 yrs (NCT05731544). Here we report initial results from the first cohort of T2DM patients treated with BMF-219. Patients with poor glycemic control (HbA1C ≥7%) on their current antidiabetic regimen were enrolled. Twelve patients were randomized 5:1 (10 BMF-219, 2 placebo) to receive 100 mg QD for 4 weeks while continuing their existing treatment. BMF-219 was well tolerated; no subjects discontinued treatment or exited the trial during the 4-week treatment and all subjects continue in follow-up to assess durability of the treatment effect. There were no dose reductions, SAEs, or severe AEs. All TRAEs were mild and observed in 3 of 12 subjects. No subjects showed symptomatic hypoglycemia. These data demonstrate preliminary proof of concept for the novel disease-modifying effect of BMF-219 in T2DM. Enrollment is ongoing at higher doses; additional follow-up data will be presented.

Disclosure

J. E. Rodriguez: None. A. Abitbol: Advisory Panel; Abbott Diabetes, Lilly Diabetes, Dexcom, Inc., Novo Nordisk Canada Inc., Janssen Pharmaceuticals, Inc., Research Support; Abbott Diabetes, Lilly Diabetes, Zucara Therapeutics, Novo Nordisk Canada Inc., Moderna, Inc., Senseonics, Speaker's Bureau; Boehringer Ingelheim (Canada) Ltd., Lilly Diabetes, Amgen Canada, Dexcom, Inc., Novo Nordisk Canada Inc., HLS Therapeutics Inc., Janssen Pharmaceuticals, Inc., Merck & Co., Inc., Sanofi. F. Abuzgaya: None. C. Perez: None. S. Mourya: Employee; Biomea Fusion, Inc. B. Munneke: Employee; Biomea Fusion, Inc., Corvus Pharmaceuticals. S. W. Morris: Employee; Biomea Fusion, Inc. T. Butler: Board Member; Biomea Fusion, Inc., Employee; Biomea Fusion, Inc., Stock/Shareholder; Biomea Fusion, Inc.

Funding

Not applicable
Topical Dihydroartemisinin Improves Wound Healing in Diabetic Mice
Authors: Shi Shanshan , Gong Yanhong , Hu Hailiang , Peng Shuai , Liu Ju
Published: June 2023

Impaired skin wound healing is a common complication of diabetes mellitus. Angiogenesis is a critical step in wound healing because it allows oxygen and nutrients to reach the injured area, thereby promoting wound cell proliferation, re-epithelialisation, and collagen regeneration. However, the neovascularisation ability of patients with diabetes often decreases. Therefore, finding ways to improve diabetic angiogenesis is important for treating diabetic wounds that do not heal. To the best of our knowledge, it is unclear whether dihydroartemisinin (DHA) affects diabetic wounds. This study sought to determine how topical DHA affects the healing of diabetic wounds and how it is related to markers of angiogenesis. We topically applied DHA to full-thickness cutaneous lesions in a streptozotocin (STZ)-induced diabetic mouse model. Under a fluorescence microscope, the pathological morphology of the wound skin was observed, together with the positive expression of platelet endothelial cell adhesion molecule-1 (CD31) and vascular endothelial growth factor (VEGF). Western blotting was used to determine the CD31 and VEGF protein expression levels. The mRNA expression was determined using qualitative real-time polymerase chain reaction (qRT-PCR). We found that DHA can improve the expression of CD31 and VEGF, and accelerate wound healing in diabetic mice. We believe that DHA promotes angiogenesis, which is associated with increased VEGF signalling in vivo. Therefore, DHA can effectively accelerate the process of diabetic wound healing by promoting angiogenesis, implying that DHA may be used as a topical drug for the treatment of diabetic wounds.
Desenvolvimento de aplicativo para higiene do sono em adultos
Authors: Garcia Isabela Gomes , Lopes Letícia Diniz , Severo Gustavo Afonso Pires , Picinato-Pirola Melissa , Côrrea Camila Castro
Published: June 2023

Introdução: Diferentes condições clínicas podem afetar a quantidade e a qualidade do sono. As medidas de higiene do sono interferem diretamente na qualidade deste. Elas podem ser propagadas à população por meio de aplicativos. Objetivo: Desenvolver, avaliar e disponibilizar um aplicativo que contemple as medidas de higiene do sono e que seja capaz de gerar mudança e verificar a ocorrência de sonolência diurna excessiva. Metodologia: O aplicativo “Somnum” foi desenvolvido e 26 fonoaudiólogos certificados em Sono pela Associação Brasileira do Sono foram convidados a avaliar usando o questionário Emory e outro questionário elaborado pelas autoras. Após, 38 estudantes usaram o aplicativo e responderam antes e depois do uso o Índice de Qualidade do Sono de Pittsburgh e a Escala de Epworth. Resultados: Após seu desenvolvimento, o aplicativo foi avaliado por 4 fonoaudiólogas que contribuíram com suas sugestões e 38 universitários participaram respondendo os questionários, sendo que 6 deles participaram antes e após o uso do aplicativo. Sobre o Índice de qualidade de sono de Pittsburgh, foi observado na análise estatística, comparando o antes e após o uso do aplicativo, melhora da qualidade de sono (p=0,04). No que se refere ao questionário Epworth, foi verificado na situação após o uso do aplicativo “Somnum”, que não houve diferença significativa. Conclusão: Após o uso do aplicativo, verificou-se possível melhora na qualidade de sono. Houve ocorrência de sonolência diurna excessiva.
Sintomas vocais, ansiedade e depressão pré e pós-tireoidectomia
Authors: Oliveira Thais Jejesky de , Oliveira Gustavo Batista de , Depolli Gabriel Trevizani , Santos Marco Homero de Sá , Rocha Ricardo Mai , Guimarães Michelle Ferreira , Azevedo Elma Heitmann Mares
Published: June 2023

Introdução: Alterações na tireoide e a tireoidectomia podem levar à sintomatologia vocal e emocional. Objetivo: Correlacionar sintomas vocais e traços de ansiedade e depressão pré e pós-tireoidectomia. Métodos: Estudo observacional, longitudinal. Participaram 20 pacientes submetidos à tireoidectomia, ao exame visual laríngeo e à Escala de Sintomas Vocais (ESV) e Escala Hospitalar de Ansiedade e Depressão (HADS) no pré-operatório, pós 1 semana e pós 3 meses, com média de idade de 54,5 anos, maior prevalência do sexo feminino (85%) e tireoidectomia parcial (70%). Resultados: Os pacientes autorreferiram sintomas vocais em todos os momentos, com maior frequência após uma semana e diferença significativa entre o domínio físico pré e pós 1 semana. Na HADS, observou-se maior escore total no pré-operatório e diferença significante nos três momentos, em todos os domínios, com maior diferença entre pré e pós 1 semana. Houve correlação positiva fraca entre os domínios limitação, emocional e escore total da ESV com a subescala de ansiedade pós 1 semana, entre o escore total da ESV e o escore total da HADS e correlação positiva moderada entre os domínios limitação e emocional da ESV com o escore total da HADS após uma semana. Conclusão: Pacientes submetidos à tireoidectomia autopercebem sintomas vocais e traços de grau leve de ansiedade tanto no pré quanto pós 1 semana e após 3 meses de cirurgia com pior autorreferência após uma semana. Quanto maior a autorreferência de sintomas vocais, mais traços de ansiedade o paciente pode apresentar.
Contribuição do potencial evocado auditivo de estado estável na escolha do implante coclear ou aparelho de amplificação sonora em crianças com perda auditiva
Authors: Sampaio Gabriela Regina , Maruta Elaine Colombo Sousa , Azevedo Marisa Frasson
Published: June 2023

Introdução: A deficiência auditiva em crianças prejudica a aquisição e o desenvolvimento da linguagem oral, o que pode ser minimizado com o diagnóstico e a confirmação da surdez nos primeiros meses de vida. O Potencial Evocado auditivo de estado estável (PEAEE) destaca-se diante dos demais potenciais evocados auditivos devido à facilidade de registro, à objetividade das respostas, à estimulação de várias frequências simultaneamente, em ambas as orelhas, além da identificação da audição residual. Objetivo: Verificar a contribuição do PEAEE na definição terapêutica (escolha do implante coclear ou aparelho de amplificação sonora) para a reabilitação auditiva de crianças. Método: Foram analisados os registros de 20 crianças de um mês a três anos de idade com perda auditiva neurossensorial de grau severo ou profundo bilateral e que foram submetidas ao PEAEE e ao potencial evocado auditivo de tronco encefálico frequência específica (PEATE-FE). Ambos realizados nas frequências de 500 Hz e 2000 Hz no equipamento Smart-EP Intelligent Hearing Systems®. Resultados: Houve diferença entre os exames quanto à ocorrência de resíduo auditivo, pois, um número significativo de indivíduos apresentou respostas ausentes no PEATE-FE e respostas presentes no PEAEE. Não ocorreu associação entre a presença de resíduo auditivo, o grau da perda e a idade da criança com o tipo de intervenção terapêutica. Conclusão: A presença de resíduo auditivo, a classificação do grau da perda e a idade da criança não influenciaram na conduta terapêutica final.
Avaliação e intervenção responsiva e integrativa na criança com distúrbio alimentar pediátrico com Trissomia do 21
Authors: Junqueira Patrícia , Pereira Michelle Miranda , Lebl Mariana Célia Guerra , Alves Thaís Coelho
Published: June 2023

Na criança com Trissomia do 21 a dificuldade alimentar pode estar presente. Alguns sinais são as alterações na habilidade motora-oral, no processamento sensorial, tempo elevado das refeições, recusa alimentar prolongada e falta de autonomia. Ainda pouco se discute sobre as dificuldades alimentares e seu processo terapêutico nesta população. O objetivo deste estudo foi descrever a avaliação e intervenção fonoaudiológica e da terapia ocupacional na dificuldade alimentar de uma criança com Trissomia do 21 com o uso de estratégias de alimentação responsiva e integrativa. Criança 3 anos e 2 meses, sexo masculino. Avaliação fonoaudiológica demonstrou criança com distúrbio alimentar pediátrico, caracterizado por atraso na habilidade motora-oral, baixa percepção intraoral e comportamento alimentar altamente seletivo. Na avaliação da terapia ocupacional verificou-se perfil sensorial alterado. Na fonoterapia foram trabalhados aspectos como a percepção do alimento, ritmo e o tempo de alimentação. Na terapia ocupacional, o objetivo foi adequar nível de alerta, favorecer a independência e o desenvolvimento psicomotor. Após a intervenção, a reavaliação fonoaudiológica demonstrou que houve ampliação do cardápio, melhora da percepção, da habilidade motora intraoral, aceitação de diferentes utensílios e modos de apresentação do alimento, autonomia e prazer nas refeições. A reavaliação da terapia ocupacional mostrou um nível de alerta e atenção mais adequado, uso das mãos e dedos de maneira mais funcional para se alimentar. Foram observadas evoluções positivas em relação à intervenção fonoaudiológica e da terapia ocupacional na dificuldade alimentar de uma criança com Trissomia do 21 com o uso de estratégias de alimentação responsiva e integrativa.
Quais os possíveis impactos do Previne Brasil para o trabalho e educação da fonoaudiologia na Atenção Primária à Saúde?
Authors: Telles Mauricio Wiering Pinto , Lopes Lavínia Mabel Viana
Published: June 2023

O Núcleo de Apoio à Saúde da Família (NASF) incorporou diversas especialidades não contempladas nas equipes mínimas da Estratégia Saúde da Família, dentre eles, a fonoaudiologia. O NASF organizava-se em apoio matricial, um referencial teórico-metodológico vinculado aos ideais do SUS, da saúde coletiva e da Reforma Sanitária Brasileira. Após a revisão da Política Nacional de Atenção Básica (PNAB) em 2017, inicia-se o processo de omissão do apoio matricial para o NASF e a falta de clareza do papel e da cobertura desses Núcleos. No ano de 2019, o Previne Brasil, que institui o novo financiamento da Atenção Primária à Saúde (APS), extinguiu o financiamento específico para os NASF, fazendo com que a sua continuidade nos municípios fique ameaçada e o seu processo de trabalho seja completamente modificado, esvaziando o seu caráter de apoio matricial. Diante desse cenário, a presente comunicação objetiva, à luz da literatura, discutir os possíveis impactos do Previne Brasil para o trabalho e a educação da fonoaudiologia na APS. Assim, são abordados no texto: os aspectos históricos da Saúde da Família no Brasil; os avanços para a prática fonoaudiológica após a implantação do NASF; o desmonte sofrido pelo NASF após a revisão da PNAB e a instituição do Previne Brasil; e a necessidade do reposicionamento da fonoaudiologia na sociedade e no setor saúde, aproximando-se das entidades que lutam pela defesa da vida, por meio da democratização da saúde, do Estado e da sociedade, assim como encampa o movimento pela Reforma Sanitária Brasileira.
Explorando la representación gráfica de la función polinómica de tercer grado
Authors: Saborido López Natalia , Molina Zavaleta Juan Gabriel , Rosas Mendoza Alejandro Miguel
Published: June 2023

El siguiente artículo tiene el propósito de presentar los resultados de una experiencia de clase, a partir de una actividad planteada a través de la utilización del software GeoGebra, con el objetivo de que estudiantes de segundo año de bachillerato, exploraran el comportamiento del gráfico correspondiente a la función polinómica de tercer grado, particularmente en lo que refiere a sus raíces.
Trends in Centralized Protection and Control in Digital Substations
Authors: E. Torres  , P. Eguia  , O. Abarrategi  , D.M. Larruskain  , V. Valverde  , G. Buigues
Published: June 2023

In recent years, the trend of digitalization has sped up in all economic and industry sectors. In the electric power sector, new digital technologies will introduce deep changes in the architecture of protection and control systems of future electric substations to adapt to a new environment with increasing levels of inverter-based and distributed energy resources along with a large number of sensors, automation equipment and other control, protection and measurement devices.
This paper reviews the evolution of the traditional substation toward new protection and control architectures based on new computer and communication technologies. The main characteristics of virtualization technologies are also analyzed, as well as the benefits and main challenges in its application in substation protection and automation systems.
Framework to assess the stable operation of commercially available single-phase inverters for photovoltaic applications in public low voltage networks
Authors: E. Kaufhold  , J. Meyer  , J. Myrzik  , P. Schegner
Published: June 2023

This paper presents a framework to assess the grid compatibility of single-phase inverters connected to public low voltage network, which is characterized by a stable operation at reasonable emission. The assessment is based on considering emission, immunity and stability. The state of the art for commercially available devices relies only on the classical, impedance-based stability analysis based on the Nyquist criterion. However, experiences have shown that this is not sufficient for a statement towards the stable operation of an inverter, since the stable operation can also be affected by other factors than the network impedance, e.g. a background voltage distortion. Exemplary laboratory measurements of two commercially available single-phase PV inverters are presented to validate the statement by showing that despite the impedance-based stability criterion is met, inverters can still trip in presence of a high background voltage distortion. The paper concludes that the immunity of the inverter with regard to the voltage distortion at the point of connection (PoC) is additionally of importance for its stable operation.
A capacitor-free driving stage for light emitting diodes
Authors: F.A. Himmelstoss  , M. Windisch
Published: June 2023

Electrolytic capacitors have the disadvantage of pronounced aging. Non-electrolytic capacitors are therefore used in applications where long-life is important. In this paper we present a driving stage for LEDs without any capacitive elements. The basic topology is a Buck converter with one coil, one active, and one passive switch. Instead of the output capacitor, series connections of one or more LEDs and an active switch are connected. An additional diode is connected between the output and the input to achieve a current path, when all LED-paths are off. A nonlinear hysteresis controller is used to achieve a robust control. A system with three switchable LED-strings is analyzed. Design hints are given and the function is proved with the help of LTSpice simulations. The system can be used for lighting purposes with the possibility to change the chrominance. The potentiality to transmit data is also treated.
Digital Signal Processor Programming using MATLAB Simulink Embedded Coder
Authors: N. Magro  , J. R. Vázquez  , A. D. Martin  , R. S. Herrera
Published: June 2023

In this work, a computer tool developed in Matlab is presented for process control in real time. The Matlab/Simulink Embedded Code toolbox allows the programming of different commercial acquisition and control cards. In addition, it is easy to supervise the practical cases implemented both from the cards commercial interfaces and from Matlab/Simulink. This work shows how to use the Texas Instruments TMS320F28335 card, the installation of the required software to program the card and the development of a practical case to prove its performance. Thus, the way of generating a sinusoidal voltage waveform using a power DC/AC converter controlled by the PWM (pulse-width modulation) modules card, is presented. This method can be used for teaching and researching purposes, and it is also used for the electric power system management.
Technical evaluation of hybrid super capacitor technologies for local energy communities
Authors: L.Vargas  , R.Rengel  , J.Caparrós  , D.Tejada-Guzmán  , E. López
Published: June 2023

Renewable energy sources have demonstrated in recent years their ability to reduce the dependence on fossil fuels, contribute to the security of energy supply and play an important role in reducing greenhouse gas emissions. To benefit from the local use of renewable sources and energy efficiency in distributed systems, the concept of local energy communities is established. In local energy communities, new innovative technologies are combined, highlighting the role of energy storage, to provide greater autonomy to communities that adopt this model.
Among energy storage, the use of batteries stands out, while lithium batteries are currently the most widely used for domestic and residential applications, as well as in local energy communities.
This work describes the experimental evaluation of an innovative energy storage system for energy communities based on hybrid supercapacitors (HSC), focused on local energy communities, and its comparison with other well established storage technologies, such as lithium-ion batteries.
Two-step optimization algorithm for energy management and active-reactive power commands for real-time operation of hybrid microgrids
Authors: Marcial González de Armas  , Santiago Arnaltes Gómez  , Francisco Arredondo  , José Luis Rodríguez Amenedo
Published: June 2023

This paper proposes a two-step optimization algorithm for energy management and optimal control of activereactive power commands in microgrids. The first step ensures an optimal energy management and provides the active power setpoints for power plants and energy storage. The second step calculates the voltage setpoints for power plants and reactive power flows whilst minimizing power transmission losses. This work focuses on the second step of the algorithm and the framework to combine both. A previous study introduces the first step based on a receding-horizon scheme. It is analysed and discussed the performance of the algorithm against two decentralized methods widely used in the literature. The results show that the proposed algorithm reduces power transmission losses by more than 20% compared to other methods.
The use of innovative tools in the medium voltage grid development, a case study of series voltage regulator
Authors: B. Tozser  , I. Taczi  , A. Torok
Published: June 2023

The rapid technological improvements concerning the renewable energy sources and the energy policy of the European Union, and the National Energy Strategy are leading to a rapid increase in the number of intermittent renewable power plants. Thus, new challenges emerge in the operation of the distribution system. To operate the system efficiently, the use of innovative technologies must be considered, because conventional network development strategies cannot always provide an optimal solution for the problem. This paper analyses the effects of largescale wind power generation on a medium voltage system and a solution of the problems faced through a case study of a serial voltage regulator. The difference between the profiles of generation and loads causes the residential transformers at the end of the line to encounter large, more than 8% voltage fluctuation. To assess the site’s voltage profile, time series symmetrical load flow calculations were performed. After the thorough analysis of the circumstances a serial voltage regulator device was implemented at 3 different nodes of the system and a placement analysis was carried out with statistical tools. The results showed a 3% decrease in the voltage fluctuation at the end of the line even when the device was far from these nodes; and with an optimal placement, the device could halve the largest voltage fluctuation on the line.
From Needs Analysis to the Establishment of a University Vocabulary List for English Majors
Authors: Hajiyeva Konul
Published: June 2023

This paper concerns the academic vocabulary needs of undergraduate English majors in a tertiary context in Azerbaijan. Based on the results of the previous studies, it is suggested that developing an appropriate course material to meet the specific learning needs of these students will be beneficial for them. Thus, this study aims to identify the percentage of the running words and high-frequency word families beyond the 2,000 most-frequent words in the university textbook corpus to help the students to attain 98% lexical coverage. To address English majors’ scant academic vocabulary knowledge, a University Vocabulary List has been created. First, a university textbook corpus comprising the words used in 11 subject-specific course textbooks across subject areas taught at Azerbaijan University of Languages was compiled. Next, the range and frequency distribution of the words beyond the British National Corpus scale 2,000-word families was examined. Finally, the 396 most frequently occurring word families in the corpus were chosen; these formed the proposed University Vocabulary List for English majors, accounting for a 6.96% lexical coverage. The University Vocabulary List for English majors and the British National Corpus 2,000 high-frequency word families, including proper nouns, provide a text coverage of 97.28%, which is only marginally lower than the suggested lexical threshold of 98% suggested by Laufer and Ravenhorst-Kalovski (2010) and Nation (2006). It is, therefore, argued that the University Vocabulary List represents a sufficiently frequent and relevant vocabulary load for English majors whose secondary educational background and first-year general English textbooks have not equipped them for the linguistic challenges they face at the initial stages of their tertiary education. The article concludes by stating the pedagogical implications for developing these learners’ knowledge and use of the most frequent word families.
Rhetorical Strategies for Teaching Essay Writing: A Case Study Involving Saudi ESL Students
Authors: Bakri Haytham
Published: June 2023

The use of rhetorical strategy in teaching writing has been a topic of discussion in ESL training programs since most teaching methodologies do not give the mother tongue a substantial role. This article presents findings from research on the rhetorical techniques pre-service teachers employ in writing both before and after receiving process-based writing instruction. The study focused on determining the writing techniques student teachers employ to complete an argumentative essay, and finding out how much pre-service teachers’ usage of writing methods is improved by using a rhetorical process approach to writing. The significance of the present study lies in the fact that it examines the writing abilities of Saudi students with different levels of language abilities and evaluates how rhetorical strategies help them in writing English easefully and with little or no flaws. The fundamental question to be probed through this study is to what extent rhetorical strategies can help teach successful writing to Saudi ESL learners. The data was obtained via the performance of an essay task utilizing two think-aloud protocols and based on a sample of 98 student teachers from Saudi Arabia. The findings of this study show rhetorical strategies such as generating ideas and rewriting are very essential in writing final essays by students. It is clear from the results that after students have mastered the choosing ideas process, they may include concepts that are relevant to the text. Professors should spend time, particularly teaching this kind of approach to help students become competent method users and writers generally, regardless of their audience. In concluding writing an article, it seemed like the strategy of translating from the native tongue to a foreign language was being utilized
Os professores cooperantes na formação inicial de futuros docentes
Authors:   Universidade do Porto, Leite Carlinda , Marinho Paulo ,   Universidade do Porto, Sousa-Pereira Fátima ,   Universidade do Porto
Published: June 2023

Reconhecendo ser importante que futuros educadores e professores, durante a formação inicial, vivenciem experiências profissionais, devidamente acompanhados, que prepararem para a profissão, o artigo dá conta de um estudo que traz ao debate perceções de professores cooperantes (PC) sobre o modelo de formação e condições que têm para realizar a função. Recorrendo a entrevistas semiestruturadas a PC que colaboram na formação de docentes de diferentes níveis de escolaridade, o estudo responde às perguntas de investigação: que perceções têm PC sobre as condições que a formação inicial oferece para a socialização com a profissão? que relações se estabelecem entre instituições de ensino superior (IES) e Escolas/PC? que perceções têm PC sobre a adequação do perfil que possuem para o exercício das funções que devem realizar? A análise de conteúdo das entrevistas permite tecer as seguintes considerações: o tempo de estágio é curto para a preparação profissional, embora a formação assegure uma boa preparação teórica; as relações de pertença às IES influenciam a aceitação do cargo, apesar de não usufruírem de condições para o exercer; em muitos casos, as IES não estabelecem relações fortes e articuladas com os PC; os PC consideram ter perfil adequado à função, seja adquirido por investimento pessoal, pela experiência da função ou pelas oportunidades de formação que as IES oferecem.
THE CATHOLIC WOMEN'S PRESS IN INTERWAR POLAND: IN LOOKING FOR THE FIGURE OF AN IDEAL WOMAN
Authors: Vais Karolina
Published: June 2023

This article explores the representation of the ideal woman and femininity in the Polish interwar Catholic women's press, focusing on two selected publications – «Kuźniczanka» and «Gazeta dla kobiet.» In the 1920s and 1930s in Poland, Catholic periodicals were widely circulated, and the women's press developed against the backdrop of social changes caused by World War I. The Catholic women's press promoted a religious and nationalist worldview while paying attention to the new emancipation of women. In creating the image of the ideal woman, the Polish Catholic interwar press sought to influence its readers' behavior and life strategies. The article analyzes how these publications shaped the image of the ideal woman and femininity, as well as the consequences of such representation for their readership. «Gazeta dla Kobiet» emphasized the care and upbringing of children, highlighting the irreplaceable role of the mother in these areas. It advocated for constant maternal contact with the child, rationality, and moderation in relationships. The importance of religious education was also emphasized. «Kuźniczanka,» a publication that gained popularity at the national level, aimed at the religious education of adult women and the formation of a patriotic position. The magazine promoted the concept of hardworking, modest living and active participation in public work. The magazine sought to prepare its readers for the fulfillment of daily family duties and protect them from worldly temptations. The ideal woman depicted in the pages of «Kuźniczanka» was a prudent wife and mother, skilled in organizing household affairs, and a sensitive educator of the weak or socially marginalized. Both publications promoted an ideal image of a woman based on religious norms, virtuosity, hard work, and modesty. This model served to mobilize defenders of religious and national values and moral traditionalism. It also emphasized the crucial role of a properly educated woman in creating optimal conditions for the development of younger generations.
CONCEPTUAL APPARATUS OF HISTORICAL SCIENCE IN UKRAINE IN THE LIGHT OF MODERN METHODOLOGICAL RESEARCH
Authors: Isak Yurii , Slipetskyy Oleg
Published: June 2023

In the proposed article, an attempt was made to highlight the features of the conceptual apparatus of historical science in Ukraine in the light of modern methodological searches, one of the essential aspects of which is the question of the specificity and potential of scientific knowledge. In particular, the efforts and achievements of Ukrainian scientists in the study and understanding of the process of formation of the conceptual apparatus of historical science in Ukraine are highlighted. They characterized both «weaknesses» and achievements in the scientific activity of domestic historians-scientists in the field of developing the terminology system of their studies, traced the reasons for the lack of unity among them regarding several topical issues, first of all, the specifics of historical knowledge, as well as outlined the urgency and promising ways overcoming these problems at different theoretical and methodological levels. The opinion is substantiated that the definition of key concepts of historical science and their proper rethinking, coordination, unification, and redefinition according to the needs of time and the development of world science is essential for a professional historian. At the same time, it is shown that historical science, not only on the territory of Ukraine but also in the world in general, largely did not accept the achievements of science in the field of logic and renewal of the foundations of cognitive activity, perception of the world as a system, etc. The necessity of rethinking its foundations by modern historical science is revealed in connection with revolutionary changes in modern science and technology development, which forms the prerequisites for another cognitive turn. n this context, the definition of the concept of «history,» which is central for historians, as well as the related concepts of «historical fact,» «historical regularity,» «methodological canon,» etc., needs to be rethought by Ukrainian historians.
PERANAN MASYARAKAT SIPIL DALAM DEMOKRASI
Authors: Afriandi Fadli , Ariyadi Fachriza
Published: June 2023

Tulisan ini menjelaskan peran masyarakat sipil dalam pembangunan demokrasi di Indonesia. Masyarakat sipil ini tergabung dalam Lembaga Swadaya Masyarakat (LSM) yang berkontribusi dalam pengawasan terhadap kinerja pemerintahan, terutama korupsi. LSM yang dimaksud dalam tulisan ini adalah Kelompok Kerja 30 (Pokja 30) dan Jaringan Advokasi Tambang (JATAM) yang berfokus kepada masalah pencegahan, penanganan dan pengendalian kasus korupsi. Diambilnya lokus penelitian di Samarinda ini karena merupakan ibukota provinsi Kalimantan Timur dimana merupakan daerah yang berbasis kepada industri, minyak bumi dan pertambangan. Dengan demikian dapat diindikasikan bahwa Kota Samarinda memiliki pendapatan asli daerah yang besar. Tulisan ini menggunakan metode penelitian kualitatif dengan teknik pengumpulan data menggunakan Library Research. Temuan dari tulisan ini adalah peran masyarakat sipil dalam kehidupan demokrasi sangatlah diperlukan sebagai kontrol sosial dalam sebuah negara yang dapat mendorong proses demokrasi menjadi semakin baik. Hadirnya LSM Pokja 30 dan JATAM di wilayah Samarinda telah berhasil membentuk kontribusi nyata yang berperan sebagai perantara dalam menjalankan fungsi kontrol di rezim demokrasi saat ini. LSM ini membantu dan menjaga demokrasi untuk melakukan pencegahan, penanganan dan pengendalian korupsi dengan mengupayakan adanya aksi yang bersifat memediasi hubungan antara masyarakat dengan pemerintah atau negara, antara masyarakat dengan LSM dan antar LSM sendiri dengan masyarakat.
Incendiary Dramas: Black Theatre Classics and Afrofuturism
Authors: Lavender III Isiah
Published: June 2023

How do Afrofuturism and Black Theatre fit together? A provocative question worthy of deep thought! Loosely construed, Afrofuturism provides a critical descriptive lens to explore black culture that questions the commingling of race, science, and technology, with a dash of the supernatural thrown into the mix from a largely African American context which impacts how we perceive literature, music, and film. From a theatrical standpoint, live performance provides a place to see Afrofuturism at work. The live performance element, the bringing of an imagined reality to real-life, in a sense, with real people, playing the parts in front of other real people, generates amazing stories of black experience. The dynamism of Black Theatre certainly lends itself to Afrofuturist speculation and critical thought. Theatre amplifies the stuff of life--joy, sadness, oppression, violence, laughter, love, emotions that cannot otherwise be described. The beauty is in the sparked thoughts firing in resistance to being made to feel lesser.Replete with Afrofuturism, Black Theatre provokes many future visions. Douglas Turner Ward's Day of Absence: A Satirical Fantasy (1965), Lorraine Hansberry's A Raisin in the Sun (1959), Amiri Baraka's Dutchman (1964), August Wilson's The Janitor (1985), and Lynn Nottage's Poof! (1993) represent five such disparate visions ranging from a sudden mass disappearance to changing neighborhoods, to a subway ride, to a speech, to spousal abuse. Each play represents the creative force of Afrofuturism and the desire to make better futures by exploring possibilities. Afrofuturism offers both emancipatory visions and cultural alarums--lightness and dark.
Benefits and challenges of creating veterinary antibiograms for empiric antimicrobial selection in support of antimicrobial stewardship and advancement of one-health goals
Authors: Burbick Claire R. , Fajt Virginia R. , Frey Erin , Fritz Heather , Goodman Laura B. , Lorenz Catherine , Lubbers Brian V. , Marshall Edith , Rankin Shelley C. , Silva Marissa
Published: June 2023

Antibiograms are important tools for antimicrobial stewardship that are often underutilized in veterinary medicine. Antibiograms summarize cumulative antimicrobial susceptibility testing (AST) data for specific pathogens over a defined time period; in veterinary medicine, they are often stratified by host species and site of infection. They can aid practitioners with empiric therapy choices and assessment of antimicrobial resistance trends within a population in support of one-health goals for antimicrobial stewardship. For optimal application, consideration must be given to the number of isolates used, the timeframe of sample collection, laboratory analytical methodology, and the patient population contributing to the data (eg, treatment history, geographic region, and production type). There are several limitations to veterinary antibiograms, including a lack of breakpoint availability for bacterial species, a lack of standardization of laboratory methodology and technology for culture and AST, and a lack of funding to staff veterinary diagnostic laboratories at a level that supports antibiogram development and education. It is vital that veterinarians who use antibiograms understand how to apply them in practice and receive relevant information pertaining to the data to utilize the most appropriate antibiogram for their patients. This paper explores the benefits and challenges of developing and using veterinary antibiograms and proposes strategies to enhance their applicability and accuracy. Further detail regarding the application of veterinary antibiograms by privately practicing clinicians is addressed in the companion Currents in One Health article by Lorenz et al (JAVMA, September 2023).
Can the war in Ukraine thwart the green agricultural transformation in the EU? Political economy considerations regarding the case of Germany
Authors: Wandel Jürgen
Published: June 2023

The war in Ukraine threatens global food security. At the same time, the European Union (EU) plans to advance the green transformation of its agro-food sector, which implies lower agricultural output. Relying on the political economy literature, this study examines if the war can thwart the greening ambitions for EU’s agro-food sector. For this, it explores to what extent the war represents an external event that is large enough to change policy preferences and reviews the positions of major political actors who shape agricultural policy on the EU level and in member states regarding the case of Germany, where the ambition for the green transformation of the economy is particularly strong. It is shown that, for the time being, the war does not impede EU’s greening aspirations. Instead, the major political actors play for time, hoping to forward the green transformation after the end of the war.
The Discipline of Historical Liturgics in Russia: From «Unhappy Step-daughter» to Full-fledged Scholarly Discipline
Authors: Dashevskaya Zoya
Published: June 2023

The birth of liturgical research in Russia is a phenomenon that deserves careful study. The development of liturgical studies took place mainly in the Theological (Spiritual) Academies of St. Petersburg, Moscow, Kyiv and Kazan. The publication of liturgical source materials was the first step towards the establishment of an independent scientific school of liturgical studies in Russia. Thanks to Nikolai Krasnoseltsev, Ivan Mansvetov, Alexei Dmitrievskij, Ivan Karabinov and other prominent liturgists, we have a number of outstanding treatises on the liturgy of the East and West, the Typicon, both of Greek and Russian liturgical traditions, the Sacramental rites and other orders grown out of use. At present, the considerable range of matters addressed in these studies is poorly recognized, although the hypotheses of Russian scholars and their gains in methodology anticipated some of the achievements of the liturgists in the second half of the 20th century.
Pengaruh rasio keuangan terhadap kesulitan keuangan pada perusahaan sektor consumer goods di BEI
Authors: Tjandra Catherine Christiana , Widjaja Indra
Published: June 2023

The world is currently in financial distress due to the Covid-19 virus. That leads to a decrease in profit each year. Due to the intense competition, companies incur significant costs to remain competitive in their business. The purpose of this study is to measure company size in terms of liquidity, solvency, revenue growth, activity and financial hardship using IDX-listed companies in the consumer goods sector for the period 2017-2020. That was it using 30 companies, descriptive research and quantitative methods were used in this study. Targeted sampling is a sampling technique used in research. Use Eviews 12 to explore multiple regression analysis of data processing techniques. As a result, liquidity and activity have a significant positive impact, solvency has a significant negative impact, revenue growth has no significant negative impact, and firm size has a significant positive impact on financial distress. Therefore, financial indicators are an effective way to find out whether a company's financial condition is good or bad.

Kesulitan keuangan saat ini telah dirasakan oleh dunia dikarenakan adanya virus covid 19. Dimana menyebabkan adanya penurunan keuntungan pada setiap tahunnya. Adanya persaingan yang tinggi sehingga perusahaan mengeluarkan biaya yang tinggi untuk dapat unggul dalam persaingan usahanya. Tujuan dari penelitian ini untuk mengukur likuiditas, solvabilitas, pertumbuhan penjualan, aktivitas, dan ukuran perusahaan terhadap kesulitan keuangan dengan menggunakan perusahaan sektor consumer goods terdaftar dalam BEI periode 2017 – 2020. Dengan menggunakan 30 perusahaan, penelitian menggunakan penelitian deskriptif, metode kuantitatif. Purposive sampling menjadi teknik pengambilan sampel pada penelitian. Menggunakan Eviews 12 dengan melihat analisis regresi berganda untuk teknik pengolahan data. Hasil penelitian menunjukkan, likuiditas dan aktivitas berpengaruh signifikan positif, solvabilitas berpengaruh signifikan negatif, pertumbuhan penjualan tidak berpengaruh signifikan negatif, dan ukuran perusahaan tidak berpengaruh signifikan positif terhadap kesulitan keuangan. Untuk itu rasio keuangan menjadi cara yang efektif untuk mengetahui kondisi baik atau buruknya keuangan suatu perusahaan.