bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of glutathione on mitochondrial DNA and antioxidant enzyme activities in Drosophila melanogaster
Authors: YILDIZ Hülya
Published: November 2022

The free radical theory in aging assumes that the accumulation of macromolecular damage induced by toxic reactive oxygen species plays a central role in the aging process. The intake of nutritional antioxidants can prevent this damage by neutralizing reactive oxygen derivatives. Glutathione (GSH; en-L-Glutamyl-L-cysteinyl glycine) is the lowest molecular weight thiol in the cells and as a cofactor of many enzymes and a potent antioxidant plays an important role in maintaining normal cell functions by destroying toxic oxygen radicals. In this study, the effects of GSH on SOD, GST and catalase enzymes and mtDNA damage were investigated at various time intervals by giving reduced glutathione to Drosophila. It was observed that 3-week GSH administration did not have a statistically significant effect on SOD and GST activities whereas GSH application decreased the catalase enzyme activities significantly. Although the decrease in antioxidant capacity with age was observed in SOD and catalase enzymes, such a situation was not observed in GST enzyme activities. There was no statistically significant difference between the control and GSH groups in mtDNA copy number values, while in the GSH group, oxidative mtDNA damage was high. These results may be due to the prooxidant effect of GSH at the dose used in this study.
The impact of COVID-19 risk perceptions on intentions to consume energy beverages: The mediation role of a healthy lifestyle and sustainable consumption
Authors: Zahran Iyyad , Megdadi Younes , Albloush Ahmad
Published: November 2022

The COVID-19 pandemic has produced tremendous socioeconomic upheaval worldwide, affecting people’s purchasing habits and intentions. This study assesses the relationship between COVID-19 risk perceptions and intentions to consume energy drinks. Furthermore, it analyzes the role of a healthy lifestyle and sustainable consumption in mediating this relationship. A survey approach was used to obtain the data. An online questionnaire (400 samples) was distributed through social media to Palestinian citizens and residents (students, employees, free professionals, laborers, and others). The study used a 5-point Likert scale. Data analysis used descriptive statistics (measures of central tendency and dispersion). PLS was utilized to investigate the mediation effect, whereas SPSS was used to analyze the data and test the hypotheses. Risk perception was assessed using seven variables: fear, conduct, awareness and knowledge, trust and confidence, healthy lifestyle, sustainable consumption, and intention to use energy beverages. The findings indicate that COVID-19 risk perception affects the propensity to consume energy beverages (B = 3.692; p ˂ 0.001). In addition, the results show that COVID-19 risk perception has a significant relationship with a healthy lifestyle and sustainable consumption (B = 3.358; p ˂ 0.001; B = 3.571; p ˂ 0.001). The findings also highlighted a partial mediation of healthy lifestyle and sustainable consumption in the association between COVID-19 risk perception and desire to use energy beverages.
Digital tools for distance learning in the system of corporate training and personnel development
Authors: Varis Iryna , Kravchuk Oksana , Burda Anastasia
Published: November 2022

The need to choose the best ways to implement corporate training processes in extreme conditions determines the relevance of research. The adaptation of traditional learning tools to distance learning using various methods and training programs is relevant. The aim is to determine the optimal digital tools (software and online platforms) for the successful implementation of the corporate training process in a remote format in the conditions caused by the COVID-19 pandemic and martial law in Ukraine. The main approaches to the implementation and conduct of distance corporate training are considered and the need for its proactive management is highlighted. The study summarizes the types of training, vocational training methods, the main factors influencing distance learning, and online training platforms. The survey highlighted current trends in the use of distance learning in Ukrainian business practice and its effectiveness. The survey results made it possible to draw a conclusion about the current role of distance personnel learning in business practices, as well as to determine the priority of forms of training and means of its implementation. The data obtained confirm that most companies in modern world are focused on retaining staff and maintaining their high skills to improve efficiency and conserve human resources even during a pandemic and war. Digital distance learning tools should be increasingly used in the corporate training and development system.
Accelerating Digital Transformation during the COVID-19 Pandemic: A Model Design for Indonesian MSMEs
Authors: Broto Legowo Mercurius , Sorongan Fangky Antoneus
Published: November 2022

The acceleration of digital transformation and business model innovations fundamentally improves business growth and performance. However, the occurrence of the COVID-19 pandemic has a significant influence on the insecurity of many business actors, especially Micro Small Medium Enterprises (MSMEs). There are many efforts to recover the national economy by accelerating digital transformation for MSMEs programs by the government of the Republic of Indonesia. However, the problem arises when the process of accelerating digital transformation in Indonesian MSMEs is considered slow to encourage Indonesia’s National Economic Recovery (PEN as shortened in Indonesian) during the COVID-19 pandemic. The research aimed to present a design model for accelerating digital transformation during the COVID-19 pandemic for Indonesian MSMEs. The research applied a descriptive-analytic approach with a qualitative method. Then, the analysis reviewed the content analysis of previous research. The two research models were analyzed. One was from Indonesia, while another one was from outside Indonesia. The results of the model design reveal that the acceleration of digital transformation is influenced by business driving factors and impacts the gaining value from business model innovations. The model of accelerating digital transformation for MSMEs is expected to contribute significantly to supporting government programs and strengthening National Economic Recovery policies during the COVID-19 pandemic.
Automatic Fish Identification Using Single Shot Detector
Authors: Vatresia Arie , Faurina Ruvita , Purnamasari Vivin , Agustian Indra
Published: November 2022

The vast sea conditions and the long coastline make Bengkulu one of the provinces with a high diversity of marine fish. Although it is predicted to have high diversity, data on the diversity of marine fish on the Bengkulu coast is still very limited, especially in the process of fish species detection. With the development and expansion of computer capabilities, the ability to classify fish can be done with the help of computer equipment. The research presents a new method of automating the detection of marine fish with a Single Shot Detector method. It is a relatively simple algorithm to detect an object with the help of a MobileNet architecture. In the research, the Single Shot Detector used is six extra convolution layers. Three of the extra layers can generate six predictions for each cell. The Single Shot Detector model, in total, can generate 8,732 predictions. The research succeeds in identifying seven from ten genera of marine fish with a total dataset of 1,000 images, with 90% training data and 10% validation data. Each fish genus has 100 images with different shooting angles and backgrounds. The results show that the Single Shot Detector model with MobileNet architecture gets an accuracy value of 52.48% for the identification of 10 genera of marine fish.
Exploring the Best Parameters of Deep Learning for Breast Cancer Classification System
Authors: Chowanda Andry
Published: November 2022

Breast cancer is one of the deadliest cancers in the world. It is essential to detect the signs of cancer as early as possible, to make the survival rate higher. However, detecting the signs of breast cancer using the machine or deep learning algorithms from the diagnostic imaging results is not trivial. Slight changes in the illumination of the scanned area can significantly affect the automatic breast cancer classification process. Hence, the research aims to propose an automatic classifier for breast cancer from digital medical imaging (e.g., Positron Emission Tomography or PET, X-Ray of Mammogram, and Magnetic Resonance Imaging (MRI) images). The research proposes modified deep learning architecture with five different settings to model automatic breast cancer classifiers. In addition, five machine learning algorithms are also explored to model the classifiers. The dataset used in the research is the Curated Breast Imaging Subset of Digital Database for Screening Mammography (CBIS-DDSM). A total of 2,676 mammogram images are used in the research and are split into 80%:20% (2,141:535) for training and testing datasets. The results demonstrate that the model trained with eight layers of Convolutional Neural Networks (CNN) (SET-8) achieves the best accuracy score of 94.89% and 93.75% in the training and validation dataset, respectively.
Comparing SVM and Naïve Bayes Classifier for Fake News Detection
Authors: Nurhasanah Nurhasanah , Sumarly Daniel Emerald , Pratama Jason , Heng Ibrahim Tan Kah , Irwansyah Edy
Published: November 2022

Fake news has been evolving into a problem that is getting even more challenging. Technology has been misused to spread false information about many things, such as war, pandemics, and the stock market. Unfortunately, this issue is not a big deal for some people without conscious consumption of that news. Hence, being part takes a role in combating the spread of false information using the advancement of technology. This study proposed two methods of machine learning model, Support Vector Machine (SVM) and Naïve Bayes, to classify fake news. Furthermore, to assert the applicability of models by examining news articles dataset which contain two labels, reliable and unreliable news. The higher accuracy is 0.96 using the SVM model
Transposition of English Zero Derivation from Nouns to Indonesian Verbs in to Kill a Mockingbird
Authors: Fauziah Hana
Published: November 2022

The research aimed to discuss and analyze the translation of English zero derivation or conversion from nouns to Indonesian verbs using transposition strategy. The research was carried out through the qualitative method by having the constant comparative analysis whose data were collected from Harper Lee’s novel ‘To Kill a Mockingbird’. The data collection was obtained by sampling to support the description based on the classification, including morphological and syntactic categories. The findings show an obvious difference between source and target languages. This occurs when the translation of English zero derivation relies on the affixes more frequently than any other criteria. Furthermore, the overall result proves that the transposition of English conversion from nouns into Indonesian verbs can be analyzed from the verb base that can be converted into nouns, which is then called a deverbal noun, and the noun base that can be converted into a verb. The translation of English zero deverbal noun is possible to be transposed into the target language verb. In a part of formal properties, the identification of English verb base converted into noun could be characterized by the irregular verb, stress pattern, intransitive verb, and semantic complexity, at the same time when the English noun base is transposed into Indonesian verb by considering the verbal interpretation and frequency of occurrence.
Stereotyping Representation of Kensi Blye’s Character in Television Crime Drama Series NCIS: Los Angeles
Authors: Indradjaja Nobella , Chamdani Chamdani , Syafi'i Syafi'i
Published: November 2022

The research discussed a stereotyping representation of Special Agent Kensi Blye, one of the female characters in the crime drama series ‘NCIS: Los Angeles series’. In the crime drama genre, a very masculine genre, the notion of a female character having masculine traits was common. Another issue was how the other male characters in the television show saw Kensi Blye. Their willingness to openly accept that Kensi Blye had more masculine traits than her feminine traits would be discussed. To analyze the representation of Kensi Blye, the three-dimensional framework was used as the approach. The research data were gathered from the utterances expressed by Kensi Blye’s co-workers about Kensi. The textual analysis would be the analysis of obtained data using a social actor network. Then, the resulting data would be analyzed using the feminine and masculine traits to find out how the other co-workers represent Kensi Blye’s character. The finding suggests that as the only female field agent, Kensi Blye seems to have a strong character, but in certain situations, her male co-workers still question her femaleness. The stereotyping of femaleness in female characters is inevitable even in the masculine genre of television cinema.
The effectiveness of using a homeopathic preparation containing calendula, witch hazel, aesculus, menthol and zinc oxide in patients with nasal obstruction in vasomotor and chronic subatrophic rhinitis
Authors: Zakharova G. P. , Ivanov N. I.
Published: November 2022

Introduction. In recent years, the world has seen an increase in the number of patients with difficulty in nasal breathing due to nasal obstruction, one of the causes of which are functional disorders of the nasal mucosa in various forms of rhinitis. Frequent use of intranasal decongestants among the population further contributes to the lack of effectiveness of conservative treatment and the need for surgical correction to restore free nasal breathing. This article discusses the possibility of using a homeopathic preparation containing calendula, witch hazel, aesculus, menthol and zinc oxide in patients with nasal obstruction in vasomotor and chronic subatrophic rhinitis to stop the clinical manifestations of the disease and improve the quality of life of patients.   Аim. Тo evaluate the effectiveness of a drug containing calendula, witch hazel, aesculus, menthol and zinc oxide in patients with vasomotor and chronic subatrophic rhinitis in the complex treatment of nasal obstruction.   Мaterials and methods. The study involved 48 adult patients of both sexes, aged 20 to 50 years, diagnosed with vasomotor (idiopathic) rhinitis in 24 and chronic subatrophic rhinitis in 24 patients. The studied preparation containing calendula, witch hazel, esculus, menthol and zinc oxide was smeared on the mucous membrane of the nasal cavity by laying gauze turundas for 5 minutes, 3 times a day, while the course of treatment was 10 days. The efficacy and safety of the drug was assessed by the dynamics of the severity of subjective symptoms, objective clinical data during control examinations by an otorhinolaryngologist in points, as well as by the presence of side effects in the treatment of the disease.   Results. Results of the study showed a pronounced positive trend in the form of relief of subjective complaints and the main clinical manifestations of the disease, accompanied by an improvement in the quality of life in patients in both groups examined during treatment. Side effects were not observed in patients in both study groups.   Conclusions. Based on the results of the study, conclusions were drawn about the efficacy and safety of using a complex homeopathic preparation containing calendula, witch hazel, esculus, menthol and zinc oxide in an adult group of patients with nasal obstruction, which makes it possible to recommend it for widespread use for the complex treatment of nasal syndrome. obstruction in vasomotor and chronic subatrophic rhinitis, as well as other forms of rhinitis accompanied by nasal obstruction syndrome.
Etiological factors of facial nerve stimulation in cochlear implant users
Authors: Kuzovkov V. E. , Lilenko A. S. , Sugarova S. B. , Tanaschishina V. A. , Kaliapin D. D. , Luppov D. S. , Skirpichnikov I. N.
Published: November 2022

Cochlear implantation is a high-tech method of rehabilitation of persons with complete deafness. However, cochlear implantation in patients may be accompanied by a number of difficulties due to the peculiarities of the structure of the cochlea, the relative position of anatomical structures relative to it and the nature of the acquired pathology of the inner ear. The reaction of the facial nerve during stimulation of one of the electrodes of the cochlear implant system is a common complication that can lead to a deterioration in the patient’s quality of life due to significant discomfort and restrictions on the use of the cochlear implant system. The debut of twitching of facial muscles in patients after cochlear implantation can occur both at the stage of connecting the speech processor and at the stages of further rehabilitation, which according to world literature can reach an interval of 10 years from the moment of surgery. Anatomical features of the cochlea, its interposition with the facial nerve, changes in the bone labyrinth, further progression of remodeling or ossification of the cochlea play a significant role in the development of symptoms of facial nerve stimulation in patients with sensorineural hearing loss of the IV degree, including at the stage of subsequent settings of the speech processor. The frequency of occurrence of this complication in various literature sources varies from 1 to 14.9 %. The purpose of this work is to review the world literature on the etiology of facial nerve stimulation in users of cochlear implants, highlighting the main theories of the origin of non-auditory sensations in this category of patients, since the data conducted in various studies are variable, and with a certain etiology reaches 38 %.
New treatment options for acute respiratory viral infections
Authors: Ryazantsev S. V. , Mazeinа E. S. , Budkovaia M. A.
Published: November 2022

The treatment of acute respiratory viral infection remains an urgent public health problem. There are currently a limited number of drugs used for the treatment and prevention of this pathology with proven efficacy and safety. According to current views in the field of immunology, the most important role in immune protection against both viruses and bacteria is played by molecules and receptors that form the so-called “immune synapse”, understood as a contact of cells involved in the detection of an antigen and triggering the subsequent chain of reactions to destroy it. A complex antiviral drug that has the ability to modulate rather than block the activity of its target molecules is a product containing technologically treated antibodies to interferon gamma, CD4 and domains of the main histocompatibility complex. The combined action of its components helps to reduce the infection load on the body, reduce the severity of symptoms of SARS during the first days, reduce the duration of the infectious disease. The pharmacological effect of the drug is achieved by acting on the key molecules and receptors involved in the recognition of pathogens of both viral and bacterial origin by the immune system. In addition, the product has a direct effect on IFN-γ, which results in stopping the multiplication of viruses and protecting healthy cells from infection. The use of the antibody-based drug reduces the risk of complications and helps to increase the body’s resistance to the main pathogens of viral and bacterial infections of the respiratory tract. According to the results of clinical trials, this drug has shown high efficacy and safety in the treatment of acute respiratory viral infections (ARI) in adults. The use of antibody-based medicine in paediatric acute respiratory infections and COVID-19 treatment in an outpatient setting is currently being investigated in multicentre, double-blind, placebo-controlled randomised trials.
Results of unloading therapy of acute infectious rhinitis with 0.1% xylometazoline
Authors: Kiselev A. B. , Abdulkerimov K. T. , Chaukina V. A. , Abdulkerimov Z. Kh. , Andamova O. V. , Avtushko A. S.
Published: November 2022

Introduction. Acute infectious rhinitis refers to the frequent causes of discharge therapy with nasal decongestants.   The aim to analyze the clinical features of unloading therapy of acute infectious rhinitis with 0.1 % xylometazoline according to the materials of the research centers of Novosibirsk and Yekaterinburg.   Materials and methods. In the research centers of Novosibirsk and Yekaterinburg, patients with acute infectious rhinitis were observed. Intranasal therapy in the study groups (group 1) and in the comparison groups (group 2) was carried out with 0.1 % xylometazoline spray for 7 days. Group 2 additionally received silver preparation intranasally. The need for decongestant and the state of mucociliary transport (MCT) were evaluated.   Results and discussion. Initially, patients with normal MCT rate at 1 visit in Novosibirsk accounted for 20.8 % in group 1 and 34.78 % in group 2; in Yekaterinburg – 29.17 % of patients in group 1 and 25% of patients in group 2. In the study groups, 54.2 % of patients in Novosibirsk and 100 % in Yekaterinburg used decongestant on day 5; in the comparison groups – 41.7% in Novosibirsk; 83.3% of patients in Yekaterinburg. On day 5, the volumetric air flow velocity was determined to be more than 900 cm3/s in all patients. Decongestant was used for more than 7 days by 40.35 % of patients in the first groups and 12.45 % of patients in the second groups. Inhibition of MCT on the 14 th day of follow-up, detected in two research centers, amounted to 5.26 % of patients.

   Conclusions. On the 5th day of unloading therapy, nasal breathing is objectively free. Intranasal antiseptic therapy reduces the probability of using decongestant for more than 7 days by 27.9 %. Inhibition of MCT when using 0.1 % xylometazoline should be attributed to frequent reactions.
Possibilities of phytopreparations in treatment of patients with pharyngeal pathology
Authors: Svistushkin V. М. , Nikiforova G. N. , Novtseva E. S. , Zolotova A. V. , Shevchik E. A.
Published: November 2022

Patients with infectious- inflammatory diseases of the pharynx make up a significant percentage on the intake of otorhinolaryngologists and therapists. Most pharyngeal diseases have pronounced clinical signs, have a significant impact on the performance and quality of life of patients, and have a fairly high risk of a complicated course. It is important for such patients to therapeutically provide relief of pain syndrome and stop inflammatory changes. Pharyngeal diseases and their consequences place a pronounced economic burden on the health system and society as a whole. Timely and correctly selected treatment contributes to a favorable resolution of the pathological process, against the background of preserving the protective functions of the pharyngeal mucosa and is economically feasible. Herbal preparations are effective drugs for this purpose. Phytopreparations have long been actively used in clinical practice due to their effectiveness, safety and accessibility. According to the literature, the administration of herbal preparations as monotherapy in patients with acute infectious and inflammatory pharyngeal diseases was found to be a highly effective way of treatment. The active ingredients, chamomile, marshmallow and horsetail contribute to the improvement of the body’s nonspecific defences due to enhancement of phagocytic activity of macrophages and granulocytes. Polysaccharides, essential oils and bioflavonoids of chamomile, marshmallow and yarrow have an anti-inflammatory effect and reduce oedema of the respiratory tract mucous membrane. In addition to antimicrobial and anti-inflammatory effects, herbal preparations have an immunomodulatory effect, which is particularly important because infectious inflammation, trauma, chronic stress entail a secondary immunodeficiency condition. Unnecessary prescriptions of antibacterial drugs, deterioration of the ecological situation contribute to the development of this condition. The immunomodulating effect of phytopreparations is promising not only in the treatment of upper respiratory tract pathology, but also in the secondary prophylaxis and the prevention of chronization of inflammation processes.
Atypical depression: frequency of symptoms
Authors: Nikolaeva P. V. , Fofanova Y. S. , Nikiforov I. A. , Aronov P. V. , Belskaya G. N.
Published: November 2022

Introduction. The relevance of the study is determined by the increase of atypical forms of depression, which is especially characteristic of outpatient affective disorders. In this case, the frequency of occurrence of individual atypical depressive symptoms requires clarification.Aim. To determinate the prevalence of atypical symptoms in patients with depressive disorder.Materials and methods. Patients (87 subjects) with depressive disorder, aged 18–70, who gave inform consent. The selection criterion was the result of psychometric research using The Hospital Anxiety and Depression Scale (HADS): the study included patients who scored more than 7 points. Patients with severe organic insufficiency and neurological diseases, alcohol and substance abuse were excluded. The study used clinical psychometric and statistical methods. The main examination tool is stimulus material in the form of a table with a list of atypical depressive symptoms.Results. Based on the psychometric assessment, patients were divided into two groups: patients with subclinical depression included 19 patients, patients with clinically severe depression included 68 patients. Among patients with subclinical depression, increased anxiety (89.5%), mood reactivity (84.2%), hypersonium (78.9%), hyperphagia (73.7%) and somatized symptoms (73.7%) were most often recorded. Among patients with clinically pronounced depression, increased anxiety (91.2%), somatized symptoms (80.9%), hypersonium (79.4%) and inverted daily rhythm (72.1%) were most common.Conclusion. The data obtained confirm the high prevalence of symptoms of atypical depression among patients with depressive spectrum disorders. The frequent occurrence of anxious and somatized symptoms in the structure of depression, as well as hypersomnia, was demonstrated. It seems relevant to further study the prevalence of separate symptoms of atypical depression.
Combined effect of succinic acid, riboxin, nicotinamide, riboflavin for the treatment of chronic brain ischaemia
Authors: Maksimova M. Yu.
Published: November 2022

Introduction. Сhronicbrain ischaemiais associated with the generation of oxygen free radicals resulting in a condition of oxidativestress. Various studies have investigated that antioxidant compounds can neutralize reactive oxygen species and free radicals.Aim. To evaluate effect of Cytoflavin (INN: inosine + nicotinamide + riboflavin + succinic acid) for the treatment of chronic brain ischemia.Materialy and methods. In a double-blind, placebo-controlled clinical study 50 patients aged 61 ± 9 years with chronic brain ischemia (vascular cognitive impairment), were randomized into Cytoflavin (n = 32) group or placebo (n = 18) group. The sealed envelopes system was used to randomize patients; 10.0 ml of the compound were infused by drops intravenously for 10-day period. During the course of treatment, therapy with vasoactive, nootropic and psychotropic drugs was excluded. In addition to clinical evaluation were carried outa comprehensive neuropsychological testing of cognitive functions, registration of cognitive induced potentials (IP) P300 and study of cerebral hemoperfusion using single photon emission computed tomography. To assess the intensity of lipid peroxidation we estimated several kinetic parameters of ferrous iron-induced chemiluminescence.Results. Prevalence of good and excellent results of treatment was registered in patients treated with Cytoflavin comparing with those placebo (56% vs. 22%; р = 0.036). Psychological examination showed more expressed positive dynamics of physic activity rate in treatment with the active preparation comparing with those placebo (972 ± 184 sec vs. 1 251 ± 449 sec; р = 0.005). In the group of patients treated with Cytoflavin IP P300 showed the increase of P300 peak amplitude (before treatment 5.2 ± 1.2 mV, after treatment 7.2 ± 2.1 mV; р = 0.035). The biochemical basis of the therapeutic action of Cytoflavin was its antioxidant activity: Cytoflavin increased the endogenous antioxidant background (before treatment 46.8 ± 16.1 sec, after treatment 62.4 ± 13.6 sec, р = 0.004).Conclusions. Cytoflavin produces positive effects on the main symptoms in patients with chronic brain ischaemia, increases endogenous antioxidant background and possesses certain neurotropic activity.
Post-covid syndrome: psychoneurological disorders in focus
Authors: Vasileva A. V.
Published: November 2022

The outbreak of the novel coronavirus infection pandemic has spread all over the world millions of people have been recovered from it that makes necessary the research of their health status after the acute infection phase. The accumulated data about previous coronavirus epidemics showed their prolonged impacton the nervous system with the manifestation of mental and neurological symptoms. Specialists from different countries from the beginning of the pandemic have revealed typical symptoms in patients recovered from coronavirus infection with negative tests still complained on residual respiratory, gastroenterological and psychoneurological symptoms that manifested with asthenic, cognitive, dissomnic and affective disorders, anosmia and changes in taste preferences. No correlation between infection severity and symptoms set in the reconvalescence period has been found. Different countries have been used different terms to describe it like prolonged, long, chronic covid.The leading medical centers have made their impact in this problem analysis During the two recent years a big international research base, including the data from electronic medical histories has been accumulated concerning COVID 19 reconvalescents health status. WHO has presented the postcovid 19 syndrome work definition, in its structure psychoneurological symptoms such as asthenia, anxietydepressive and cognitive disorders, insomnia play an important role. The healthcare provision for the patients with postcovid syndrome remains the issue needed further elaboration , the most promising treatment plan seems the combination of pharmacotherapy with psychosocial interventions. Tofizopam as a drug with anxiolytic, secondary precognitive and aniastenic effects can be recommended for the postocovid syndrome psychoneurological symptoms.
Female and Male Genital Morphology of Labidostomis decipiens Faldermann, 1837 (Chrysomelidae: Clytrinae)
Authors: CORAL ŞAHİN Didem
Published: November 2022

Labidostomis decipiens Faldermann, 1837 specimens collected from Ankara, Konya and Mersin, which were donated to the Nazife Tuatay museum by Prof. Dr. Halil Kasap, were examined. The paper presents morphological features of aedeagus and spermatheca of Labidostomis decipiens Faldermann, 1837 (Coleoptera: Chrysomelidae: Clytrinae) from Turkey for the first time. Accordingly, detailed investigations of aedeagus and spermatheca are very important to obtain new diagnostic characters in Labidostomis. Photos in stereo microscope are also given in the text.
Three New Records from Euglenozoa In Acarlar Floodplain Lake For Turkish Freshwater Algal Flora
Authors: TUNCA Hatice
Published: November 2022

Acarlar Lake is a freshwater floodplain lake that consists of swamps and forests growing up on inorganic soils and exposing to seasonal floods. During the studies carried out in Acarlar Lake Floodplain (Sakarya) between February 2011 and May 2011, three new records were identified for the freshwater algae of Turkey from the samples obtained from Ceratophyllum demersum L. and Typha sp. L. plants. These species are Phacus gigas Cunha, Phacus undulatus var. major (Prescott) Huber-Pestalozzi, and Trachelomonas sydneyensis Playfair belonging to Euglenozoa.
Fabrication of Mandarin (Citrus reticulate L.) peel essential oil and nano-calcium carbonate incorporated polylactic acid/polyvinylpyrrolidone electrospun webs
Authors: PARIN Fatma Nur , SICAK Yusuf , ELİUZ Elif , TERZİOĞLU Pınar
Published: November 2022

Fibrous materials from polylactic acid (PLA) and polyvinylpyrrolidone (PVP) containing mandarin peel essential oil (MPEO) and/or nano-calcium carbonate were prepared by electrospinning process. The electrospun webs were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and microbiological tests. IR spectra results indicated the existence of interaction among additives and polymer matrix. Obtained SEM results showed that incorporation of essential oil to the polymer matrix have a remarkable effect on the fiber morphology. Essential oil incorporation increased the fiber diameters. The electrospun composite webs were ineffective against Acinetobacter baumannii, Bacillus subtilis, Escherichia coli, Enterococcus fecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus.
Multivariate Machine Learning Approach for Size and Shape Prediction of Sunflower Seeds
Authors: ÇETİN Necati
Published: November 2022

Sunflower constitutes an important source of protein, mineral, vitamin, fatty acid, and offer a balanced source of amino acids. Machine learning is mostly performed for the prediction of descriptive attributes in the quality evaluation of foods. In this study physical attributes of two different sunflower varieties (Metinbey and İnegöl Alası) were determined and algorithms were applied for size and shape prediction of these varieties. In addition, five different machine learning predictors were used as Multilayer Perceptron (MLP), Gaussian Processes (GP), Random Forest (RF), k-Nearest Neighbors (kNN), and Support Vector Regression (SVR). The prediction of surface area, volume, geometric mean diameter, aspect ratio, elongation, and shape index were based on the main physical attributes. İnegöl Alası variety had the greatest physical attributes. The seed length, width and thickness were obtained from İnegöl Alası variety as 23.89, 8.80 and 4.15 mm and from Metinbey as 17.88, 6.20 and 4.01 mm. All varieties were determined as significant in terms of the selected attributes as reported by Pillai Trace and Wilks’ Lambda (p<0.01). In the Wilks’ Lambda statistics, unexplained of the similarities or differences among the groups was 12.30%. Present findings revealed that MLP and SVR algorithms had the greatest correlation coefficients for all predicted attributes. In the study, the best predicted attributes were geometric mean diameter with an R value of 0.9989 (SVR), followed by volume and elongation with an R value of 0.9988 (MLP). Present findings revealed that MLP and SVR algorithms could potentially be used for size and shape prediction of sunflower varieties.
Eksenatidin 3D 3T3-L1 Adipositleri Üzerindeki Ekspresyon Profilinin Mikrodizin Analizi ile Belirlenmesi
Authors: KOLDEMİR GÜNDÜZ Meliha , KAYMAK Güllü , KANBUR Ertan , BERİKTEN Derya , ŞAHİN Meryem Cansu , ŞENER Harun , YERLİKAYA Azmi
Published: November 2022

Obezite karmaşık, çok faktörlü ve dünya genelinde önemli bir sağlık sorunudur. Obezite tedavisi için mevcut stratejiler oldukça kısıtlıdır. Bu nedenle yeni ilaç geliştirilmesi oldukça önemlidir. Çalışmanın amacı, GLP-1 agonisti olan eksenatidin 3 boyutlu (3D) 3T3-L1 adipositleri üzerindeki sitotoksisitesinin, tüm genom profili üzerinden araştırmaktır. Bu çalışmada, eksenatidin 3D adipositler üzerindeki apoptotik ve lipolitik etki düzeyleri de araştırıldı. Eksenatidin 3T3-L1 adipositleri üzerindeki sitotoksik aktivitesi MTT yöntemi ile belirlendi. mRNA' ları taramak için fare geni mikrodizisi kullanıldı. Apoptoz çalışmaları ELISA yöntemi ile yapıldı. Lipoliz analizi, Lipolysis Colorimetric Assay Kit ile gerçekleştirildi. 3D yağ doku modellemesinde eksenatid uygulaması apoptoz seviyesini arttırdı (p<0.01). 3D 3T3-L1 adipositleri ile yapılan deneyler, eksenatid uygulamasında lipolitik etkinin yüksek olduğunu gösterdi (p=0.000). 3D adiposit hücrelerinde mRNA'ların ekspresyon profillerini göstermek için yapılan transkriptom analizlerinde, eksenatid uygulanan grupta kontrol adiposit hücreleriyle kıyaslandığında toplam 3472 mRNA farklı şekilde ifade edildi (p<0.05). Bu çalışmadan elde edilen sonuçlar, eksenatidin, çeşitli genlerin anlatımını, adiposit apoptozunu ve lipoliz aktivitesini düzenleyerek obezite tedavisinde etkili olduğunu gösterebilir.
Uçucu Kül ve Kalsiyum Alüminat Çimentosu Katkılı Pomza Esaslı Geopolimer Harçların Sülfürik Asit Direnci
Authors: KARAASLAN Cemal , YENER Engin , BAĞATUR Tamer , POLAT Rıza , GÜL Rüstem
Published: November 2022

Bu çalışmada, uçucu kül ve/veya kalsiyum alüminat çimentosu ağırlıkça toplam toz bağlayıcının %10, 20 ve 30’u kadar pomza ile ikame edilerek pomza esaslı geopolimer (PGP) harçlar üretilmiştir. Ortam sıcaklığı ve 60 °C’de kür edilen bu harçlar, 28. günde %5 derişime sahip sülfürik asit (H2SO4) çözeltisine konularak 120 gün bekletilmiştir. PGP numunelerde sülfürik asit etkisiyle oluşan görsel değişim, ağırlık kaybı ve kalan basınç dayanımı, 60 ve 120. günde ölçülmüş ve Portland Çimentosu esaslı referans harçla kıyaslanmıştır. Çalışma, referans numunelerinin sülfürik asit ortamında çözünerek 60 günün sonunda %25.6 ağırlık kaybı yaşadığını buna karşılık %20 ve 30 oranında kalsiyum alüminat çimentosu içeren karışımların ortam sıcaklığında kür edilmiş numuneleri hariç PGP harçlarda (görsel açıdan) bir çözünme olmadığını göstermiştir. Ayrıca ortam sıcaklığı ve 60 °C’de kür edilen PGP numunelerin 120 günün sonunda sırasıyla en fazla %6.5 ve 4.1 ağırlık kaybına uğradıkları tespit edilmiştir. PGP harçlar, sülfürik asit çözeltisinde 120 günün sonunda %70’e varan basınç dayanım kayıpları yaşamıştır. Ancak yeterli miktarda uçucu kül ve kalsiyum alüminat çimentosu ikamesi ile PGP harçların basınç dayanımı önemli derecede arttığı gibi sülfürik asit direnci de iyileşmiştir
Kuru Şartlarda Farklı Sıra Aralıklarla Yetiştirilen Kinoa (Chenopodium quinoa Willd.) Çeşitlerinin Silaj Kalitesinin Belirlenmesi
Authors: GÜNER Zeynep , TEMEL Süleyman
Published: November 2022

Kinoa tohumları yaygın bir şekilde insan beslenmesinde kullanılırken, son yıllarda otu da hayvan beslenmesinde tercih edilir hale gelmiştir. Ancak kurutulduğunda kinoanın yaprakları ufalanıp dökülmekte ve sapları da sertleşmektedir. Bu da, sindirilebilirdik oranını ve lezzetliliğini düşürdüğü için kinoanın kuru ot olarak kullanımını sınırlandırmıştır. Bu nedenle kinoa otunun silaj olarak değerlendirilmesi bir avantaj olarak görülmüştür. Mevcut araştırma ile kuru şartlarda 4 farklı sıra aralığı (17.5, 35.0, 52.5 ve 70.0 cm) ile yetiştirilen 2 kinoa çeşidinin (Sandoval Mix ve Oro de Valle) silaj kalite özelliklerinin (kuru madde oranı, amonyak üretimi, silaj pH’sı, olması gereken pH, yaprak oranı, ham protein oranı, NDF oranı, ADF oranı, ham kül oranı, fleig puanı, duyusal analizler, laktik asit, asetik asit, propiyonik asit ve bütirik asit oranı) belirlenmesi hedeflenmiştir. Bu amaçla 2021 yılında tesadüf bloklarında faktöriyel deneme desenine göre üç tekerrürlü bir deneme planlanmıştır. Çalışma sonucunda Sandoval Mix çeşidine göre Oro de Valle çeşidinin daha yüksek kuru madde oranına, olması gereken pH’a, laktik asit, propiyonik asit ve bütürik asit oranına ve daha düşük yaprak oranına, ham protein, ham kül ve asetik asit oranına sahip olduğu görülmüştür. Sıra aralığı açısından değerlendirildiğinde, sıra aralığı arttıkça kuru madde oranı ve olması gereken pH düşerken, yaprak oranı, ham protein, ADF, ham kül ve asetik asit oranının arttığı belirlenmiştir. Mevcut bu sonuçlar kaliteli bir silaj için ekimlerin dar sıra aralığında yapılması gerektiğini ve Oro de Valle çeşidinin silajlık materyal olarak kullanılabileceğini göstermiştir. Ancak daha kaliteli bir kinoa silajı için laktik asit üretimini arttıran, amonyak üretimini ve pH’yı düşeren katkı maddelerinin kullanılması gerektiği sonucuna varılmıştır.
THE CULTURAL ADAPTATION, RELIABILITY AND VALIDITY OF THE TURKISH VERSION OF THE SIMPLE PHYSICAL ACTIVITY QUESTIONNAIRE IN COMMON MENTAL DISORDERS
Authors: ŞENEL Aybike , BİRİNCİ Tansu , İPEKÇİOĞLU Derya , YEŞİLKAYA Haluk , KAYA MUTLU Ebru
Published: November 2022

Purpose: This study aims to evaluate the validity and reliability of the Turkish version of the Simple Physical Activity Questionnaire (SIMPAQ-T) in patients with common mental disorders.

Methods: A total of eighty-one patients (mean age: 40.14±13.05 years) were included in this study. The SIMPAQ-T was used to evaluate the participants' physical activity levels and sedentary behaviors. To be used as descriptive data, DSM-5 Level 1 Cross-Cutting Symptom Measure-Adult was used to evaluate mental health symptomatology. International Physical Activity QuestionnaireShort Form (IPAQ-SF) and Brief Psychiatric Rating Scale (BPRS) were used to test the validity of the questionnaire.

Results: The items of the SIMPAQ-T exhibited excellent intercorrelation coefficient (ICC) values (time spent in bed (0.93 (95% CI: 0.90-0.96)), sedentary time 0.87 (95% CI: 0.80-0.92), walking time 0.98 (95% CI: 0.98-0.99), exercise time 0.99 (95% CI: 0.99-0.99), and incidental activity time 0.95 (95% CI: 0.92-0.97)). The SIMPAQ-T was moderately correlated with IPAQ-SF in terms of sedentary (rho=0.641, p=0.001) and walking time (rho=0.564, p=0.001), indicating good construct validity. However, the BPRS had a significant correlation with only the sedentary time of the SIMPAQ (rho=0.246, p=0.022), indicating convergent validity was poor.

Conclusion: The SIMPAQ-T is semantically and linguistically adequate to quickly assess physical activity level and sedentary behavior in patients with common mental disorders.
The frequency of osteoporosis in the thoracic surgery patient population: An opportunity assessment from thorax computed tomography scans
Authors: SUBAŞI Mahmut , EREN Abdulkadir
Published: November 2022

Aim: To investigate the frequency of osteoporosis in thoracic surgery patients and highlight the clinical significance for physicians.Methods: Thoracic computed tomographies (CT) of 306 patients were examined for medullary density of the T12 vertebra. Men and women, as well as those under 70 and over 70, were compared in terms of Hounsfield units (HU). To evaluate the diagnostic performance of the age parameter in predicting osteoporosis, receiver operating characteristic (ROC) analysis, and logistic regression analysis were used. The rib cortical defects identified in this study group and their causes were explained.Results: HUs of 51 subjects (or 16.7%) were less than 110 (osteoporosis); 177 people (57.8%) were higher than 160 (normal). HU values ranged from 111 to 159 (borderline) for 78 individuals (25.5%). There was no significant difference between males and females. It was discovered that the difference between the population under 70 and the population over 70 was statistically significant (p<0.001). For predicting osteoporosis, the age exhibited an area under the curve of 0.857 (CI 0.806-0.908). The threshold value was 57 for women and 55 for men. Osteoporosis was shown to be accurately predicted by age with a 95.7 percent accuracy rate (p<0.001). Six patients were determined to have rib cortical defects seen on CT scans during the evaluation for osteoporosis, and two more patients had fractures noted during surgery.Conclusion: Within the 306 patients, only 57.8% had bone density within the normal range. The age parameter is valuable with high accuracy (95%) in predicting osteoporosis. The presence of osteoporosis over the age of 57 in women and over 55 in men should be evaluated and measures should be taken to protect the bones during the operation and postoperative care.
Kornea nakli konusunda YouTube videoları ne kadar güvenilir bilgi sağlıyor?
Authors: YÖRÜKOĞLU Seray , AY İbrahim Ethem , GOBEKA Hamidu Hamisi , DOĞAN Mustafa
Published: November 2022

Amaç: YouTube üzerinden yayınlanan videolarda kornea nakli hakkında verilen bilgilerin ne denli güvenilir olduğunu değerlendirmek.Yöntemler: YouTube üzerinden video arama motoruna “kornea nakli” yazıldıktan sonra ekranda beliren ilk 100 video 04.03.2022 tarihinde listelenmiştir. Yükleme tarihi, yayın süresi, toplam izlenme sayısı, günlük izlenme oranı, video kaynağı ve süresi (saniye), beğeni ve yorum sayısı kaydedilen parametrelerdi. İki oftalmolog, videoları Journal of the American Medical Association (JAMA), Quality Criteria for Consumer Health Information (DISCERN), Global Quality (GQ) endekslerini kullanarak körü körüne ve bağımsız olarak değerlendirdi ve puanladı.Bulgular: Videoların kaynağı değerlendirildiğinde, 10 videonun göz hastalıkları uzmanı tarafından yüklendiği, 35 videonun televizyon programından belli bir bölüm içerdiği, 14 videonun herhangi bir sağlık kuruluşu ve 22 videonun ise diğer kaynaklar tarafından yüklendiği tespit edilmiştir. Kaynağı televizyon programı olan videoların süresinin anlamlı olarak (p<0.05) daha uzun olduğu izlenmiştir. DISCERN sınıflandırmasına göre videoların %21’i “çok zayıf”, %45.7’si “zayıf”, %17.3’ü “orta”, %13.6’sı “iyi”, %2.5’i “mükemmel” idi. DISCERN sınıflandırması ve video süresi (p<0.01) ile video beğenisi (p=0.013) arasında anlamlı fark olduğu görüldü. Kaynaklara göre DISCERN, JAMA, GQ skorları değerlendirildiğinde anlamlı bir fark olmadığı görüldü. Beğeni sayısı, görüntülenme sayısı, görüntülenme oranı ve videodaki yorum sayıları arasında yüksek korelasyon olduğu tespit edilmiştir (p<0.01).Sonuç: YouTube sağlık alanında sıkça bilgi kaynağı olarak kullanılan bir platformdur ve kornea nakli ile ilgili önemli ölçüde içerik mevcuttur. Ancak bu içeriklerin yüksek oranda çok zayıf kalitede olduğu tespit edildi. Çoğu hastanın tek bilgi kaynağı olarak YouTube’u baz alabildiği unutulmamalı bu nedenle içeriklerin yüksek kalitede, güncel ve doğru olması gerektiği göz önüne alınmalıdır.
Process for sandblasting silicon slabs as part of semiconductor transistor manufacture
Authors: Shakhmaeva A. R. , Kardashova G. D. , Kazalieva E. , Yevdulov D. V.
Published: November 2022

Aim. The paper aims to develop a process for treating the back side of silicon slabs and giving them a surface texture that enables good adhesion with printed metal with an even thickness and no mechanical stress, cracks or chipping. That is achieved by sandblasting slabs before contact material application. Silicon carbide (SiC) with particle size not exceeding 6 um is used as the abrasive material. Methods. The proposed method of sandblasting improves chip bonding by eliminating surface stress, formation of microcracks and crystal grain within the chip. The research was conducted using a sandblaster and electronic microscope. Results. It was shown that, after sandblasting, metal coating in the process of transistor collector area contact delineation improves the adhesion of the substrate semiconductor. Additionally, no mechanical stress was observes as compared to grinding, polishing and chemical treatment that are normally done before transistor contact encapsulation. Conclusions. The process of thin metal film evaporation as part of semiconductor-based device manufacture affects their dependability. The treatment and preparation of the back side of the silicon slab with finished transistor configurations is one of the key operations as part of transistor manufacturing process that affects the adhesive properties of the surface before evaporation, output characteristics of the semiconductor-based devices, yield and cost.