bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlação das imagens da ressonância magnética e observação intra operatória nas lesões traumáticas da coluna vertebral
Authors: Marin Anderson Gomes , Herrero Carlos Fernando da Silva , Nogueira-Barbosa Marcello Henrique , Simão Marcelo Novelino , Defino Helton Luiz Aparecido
Published: May 2012

OBJETIVO: Avaliar a acurácia e a reprodutibilidade das imagens da ressonância magnética (RM) nas lesões ligamentares traumáticas da coluna vertebral. MÉTODOS: Estudo retrospectivo para avaliação das imagens da RM de 32 pacientes com lesões traumáticas da coluna vertebral submetidos a tratamento cirúrgico. A avaliação das lesões do complexo ligamentar posterior (CLP) por imagens da RM foi realizada independentemente por dois radiologistas. Um grupo de pacientes tinha exames com inclusão de sequência com supressão de gordura sensível ao líquido (STIR ou SPAIR T2), além das imagens de rotina e no outro grupo os exames de RM não incluíam imagens com a supressão da gordura. As avaliações dos exames de imagem foram comparadas com as observações obtidas durante o ato cirúrgico. Foi realizada a analise de reprodutibilidade intra e interobservador entre os dois radiologistas pelo cálculo do coeficiente Kappa. RESULTADOS: Foi observada lesão do CLP em 21/32 pacientes. De forma geral a sensibilidade da RM para lesões do CLP variou entre 88,9% a 100% e a especificidade entre 0 e 50%. A concordância entre a avaliação dos radiologistas foi maior nos exames de ressonância magnética sem a supressão da gordura (Κ=0,6) do que nos exames que incluíram sequências com supressão (Κ=0,34). CONCLUSÃO: A avaliação de lesões dos ligamentos posteriores por meio da RM pelos radiologistas resultou em boa sensibilidade em relação aos achados cirúrgicos, porém com baixa especificidade, reproduzindo resultados da literatura. Na casuística atual a utilização do sinal de edema presente nas sequências com supressão de gordura diminuiu a concordância interobservador.
Avaliação de série de pacientes com artrodese C1-C2
Authors: Ghilardi Cesar Salge , Letaif Olavo Biraghi , Iutaka Alexandre Sadao , Cristante Alexandre Fogaça , Rocha Ivan Dias , Marcon Raphael Martus , Oliveira Reginaldo Perilo , Barros Filho Tarcísio Eloy Pessoa de
Published: May 2012

OBJETIVO: Análise retrospectiva de prontuários de pacientes com instabilidade C1-C2 de causas traumáticas e não-traumáticas, submetidos à artrodese C1-C2. MÉTODOS: Foi realizada análise retrospectiva de prontuários de 20 pacientes do ambulatório de coluna do IOT-HCFMUSP com idades entre 7 e 83 anos (média de 43 anos), de ambos os sexos. Os parâmetros radiográficos para instabilidade foram baseados na medida do intervalo atlanto-axial superior a 3 mm em adultos e a 5 mm em crianças, utilizando-se medidas obtidas através de radiografia simples analisada no perfil. RESULTADOS: Foram operados 20 pacientes com instabilidade cervical alta, a maioria de origem traumática. A técnica cirúrgica mais utilizada foi a artrodese descrita por Magerl. Não foram observadas lesões vasculares. Foi registrada complicação infecciosa em dois pacientes. Obteve-se uma taxa de consolidação da artrodese de 85% e não foram necessárias cirurgias de revisão. CONCLUSÃO: Todas as técnicas utilizadas produziram a consolidação óssea satisfatória e foram excelentes para controlar a instabilidade atlanto-axial.
Chondromyxoid fibroma of C1: first case report
Authors: Sfreddo Ericson , Falavigna Asdrubal , Soares Vinícius Borges , Silva Silvia Chaves e , Nesi André , Nascimento Vinícius Carraro do , Silva Pedro Guarise da
Published: May 2012

BACKGROUND: Chondromyxoid fibroma (CMF) is a rare, benign primary bone tumor. The cervical spine is an uncommon site for this tumor, with only 10 reported cases to date and none involving the first cervical vertebra (C1). CASE REPORT: Female patient, 25-year-old monozygotic female twin, presented with cervical pain. Radiographic imaging demonstrated a contrast-enhanced, right-sided lytic lesion of the insufflated type in C1, with a punched-out appearance and extending to the anterior arch. A postero-lateral and a posterior approach were performed in two steps to resect the tumor followed by occipitocervical fixation. Pathology confirmed the diagnosis of CMF. At one year, the patient remains disease free with excellent spinal stability. CONCLUSION: Spinal surgeons may need to treat rare spinal tumors. Despite the proximity to neural and vascular structures, the goal of surgery is always a radical resection due to high recurrence rates.
Value for cultivation and use of upland rice cultivars tested in multi-environments
Authors: Borges Vanderley , Soares Antônio Alves , Resende Marcos Deon Vilela de , Reis Moizés de Sousa , Cornelio Vanda Maria de Oliveira , Leite Natália Alves , Soares Plínio César , Costa Júnior Geovani Tadeu
Published: May 2012

Data from 11 years of a breeding program for upland rice of the partner institutions Embrapa arroz e feijão, Epamig and UFLA conducted in 11 regions of Minas Gerais, were analyzed by the mixed model methodology. The genotypic correlations between environments ranged from medium to high, suggesting the predominance of simple interaction, but with differentiated ranking of genotypes at the different locations. Lines with specific performance, as well as lines of broad adaptation were identified. The performance of cultivar BRSMG Caravera, released in 2007, was superior to the others in terms of grain yield at all sites assessed, in other words, broad adaptation, in addition to a high genotypic performance.
Adaptability and stability of soybean advanced lines of semi early cycle for rust resistance
Authors: Martins Juliana Araújo Santos , Juliatti Fernando Cézar
Published: May 2012

This research work was carried out to verify the adaptability and phenotypic stability of soybean inbred lines of semi early cycle, using rust severity as the selection trait for partial resistance. The strains were evaluated during the growing seasons of 2007/08 and 2008/09, in the locations of Uberlândia and Uberaba, MG, Campo Alegre de Goiás and Senador Canedo, GO, using a randomized complete block design with three replications. Rust severity was evaluated by visual assessment of the leaflets at the medial third of five plants in each plot. By using disease severity, it was estimated: the mean absolute rate of disease progress (r), the area under the disease progress curve (AUDPC) and the partial resistance factor (PRF). Adaptability and stability of the strains were estimated by the methods proposed by Eberhart and Russell, as well as by the AMMI method. It was found that the strains which were the most resistant to rust, in general, also showed the best adaptability and stability.
BRS 336: a high-quality fiber upland cotton cultivar for Brazilian savanna and semi-arid conditions
Authors: Morello Camilo de Lelis , Pedrosa Murilo Barros , Suassuna Nelson Dias , Lamas Fernando Mendes , Chitarra Luis Gonzaga , Silva Filho João Luis , Andrade Francisco Pereira , Barroso Paulo Augusto Vianna , Ribeiro José Lopes , Godinho Vicente de Paulo Campos , Lanza Marcelo Abreu
Published: May 2012

Cotton cultivar BRS 336 is a high-quality fiber upland cultivar and has wide adaptation to the Brazilian growing areas, with resistance to bacterial blight. BRS 336 exhibited fiber length higher than 32.0 mm in all field tests. Also, fiber strength exceeded all upland cotton currently grown in Brazil.
Aesthetic Analysis of an Implant-Supported Denture at the Cleft Area
Authors: Filho Jorge Francisco Fiamengui , De Almeida Ana Lúcia Pompéia Fraga
Published: May 2012

Objective

To evaluate the aesthetics of an implant-supported denture at the cleft area, comparing the peri-implant tissues and prosthetic crown with the contralateral tooth.

Settings

Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, São Paolo, Brazil.

Patients

A total of 39 individuals of both genders, with complete unilateral cleft lip and palate, who received secondary alveolar bone graft and were rehabilitated with single implant-supported dentures at the area of the missing maxillary lateral incisor after completion of orthodontic treatment.

Interventions

The following parameters were analyzed in follow-up sessions: length and width of prosthetic crown and contralateral tooth, characteristics of implants, filling of interproximal space by the papilla, and smile height of the patients.

Results

The implant-supported prosthetic crowns were longer than the contralateral tooth ( p < .001). Among the 78 papillae analyzed, 29 (37.17%) received a score of 3; 32 (41.02%) papillae had a score of 2; and 17 (21.79%) received a score of 1. Concerning the smile height, among the 39 patients analyzed, 23 (56.41%) had a medium smile, 15 (38.46%) had a high smile, and two (5.12%) presented a low smile.

Conclusion

The use of dental implants to rehabilitate the edentulous cleft area is an excellent option. However, adequate evaluation of the bone quantity and quality, positioning and shape of adjacent teeth, smile height, and patient expectations should be considered to achieve success and avoid aesthetic deformities such as elongated teeth and absence of gingival papillae.
Glutathione Transferases as Targets for Cancer Therapy
Authors: Ruzza Paolo , Rosato Antonio , Rossi Carlo Riccardo , Floreani Maura , Quintieri Luigi
Published: May 2012

Besides catalyzing the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione, some cytosolic proteins belonging to the glutathione transferase (formerly glutatione-S-transferase; GST) superfamily are emerging as negative modulators of stress/drug-induced cell apoptosis through the interaction with specific signaling kinases. In addition, several data link the overexpression of some GSTs, in particular GSTP1-1, to both natural and acquired resistance to various structurally unrelated anticancer drugs. Tumor overexpression of these proteins has provided a rationale for the search of GST inhibitors and GSTactivated cytotoxic prodrugs. In the present review we discuss the current structural and pharmacological knowledge of both types of GST-targeting compounds.
The Nitric Oxide Prodrug JS-K and Its Structural Analogues as Cancer Therapeutic Agents
Authors: Maciag Anna E. , Saavedra Joseph E. , Chakrapani Harinath
Published: May 2012

Nitric oxide (NO) prodrugs of the diazeniumdiolate class are routinely used as reliable sources of nitric oxide in chemical and biological laboratory settings. O2-(2,4-dinitrophenyl) diazeniumdiolates, which are derivatized forms of ionic diazeniumdiolates, have been found to show potent anti-proliferative activity in a variety of cancer cells, presumably through the effects of NO. One important member of this class of diazeniumdiolates, O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K), has shown promise as a novel cancer therapeutic agent in a number of animal models. This review describes the developments in chemical and biochemical characterization and structure-activity relationship of JS-K and its analogues. In addition, some molecular mechanistic insights into the observed anti-proliferative activity of JS-K are discussed. Finally, a structural motif is presented for O2-(aryl) diazeniumdiolate nitric oxide prodrugs that show potency comparable with that of JS-K.
HRF-Interacting Molecules
Authors: Kawakami Toshiaki , Ando Tomoaki , Kawakami Yuko
Published: May 2012

Histamine-releasing factor (HRF), also termed translationally controlled tumor protein (TCTP) and fortilin, is a
highly conserved, multi-functional protein. This protein within a cell plays a critical role in the fundamental processes of
cell-cycle progression, proliferation, survival, and malignant transformation. The same protein, despite the lack of signal
sequence, is secreted through a nonclassical secretory pathway. The secreted protein usually termed HRF can activate
IgE-primed basophils and mast cells, and works as a B cell growth factor and a chemoattractant for eosinophils. This
structurally well-characterized protein interacts with many proteins to perform its intracellular and extracellular functions.
This review summarizes recent studies of HRF/TCTP-interacting proteins as a major driving force to decipher its
functions.
Application of QSAR models in analysis of antibacterial activity of some benzimidazole derivatives against Sarcina lutea
Authors: Podunavac-Kuzmanovic Sanja , Cvetkovic Dragoljub , Jevric Lidija , Uzelac Natasa
Published: May 2012

In the present paper, a quantitative structure activity relationship (QSAR)
has been carried out on a series of 2-methyl and 2-aminobenzimidazole
derivatives to identify the lipophilicity requirements for their inhibitory
activity against bacteria Sarcina lutea. The tested compounds displayed in
vitro antibacterial activity and minimum inhibitory concentration (MIC) was
determined for all compounds. The partition coefficients of the studied
compounds were measured by the shake flask method (log P) and by theoretical
calculation (Clog P). The relationships between lipophilicity descriptors and
antibacterial activities were investigated and the mathematical models have
been developed as a calibration models for predicting the inhibitory activity
of this class of compounds. The models were validated by leave-one-out (LOO)
technique as well as by the calculation of statistical parameters for the
established models. Therefore, QSAR analysis reveals that lipophilicity
descriptor govern the inhibitory activity of benzimidazoles studied against
Sarcina lutea.
‘I Don't Get it’: A Critical Reflection on Conceptual and Practical Challenges in Teaching Qualitative Methods
Authors: Sargeant Sally
Published: May 2012

This article is a reflective piece that concentrates on facilitating student learning styles and reflexivity when teaching qualitative methods. It elaborates specifically on the challenges of deep and surface learning, and managing these differences in conjunction with the practical challenges posed by qualitative research. The introduction of reflexivity to undergraduate students and how this can be conveyed effectively is also discussed in connection with learning how to execute qualitative work. The teaching context was a section on qualitative methods that formed part of a larger research methods module. Student feedback indicates that time constraints and group-work affect the learning process. In conclusion, improvements can be made by attending more closely to deep learning strategies and reducing the number of activities in class, to ensure that the quality is maintained within the teaching of qualitative research.
Taking another Look: Developing a Sustainable and Expandable Programme of Qualitative Research Methods in Psychology
Authors: Fielden Amy L. , Goldie Sarah , Sillence Elizabeth
Published: May 2012

This report reflects on the current provision of qualitative research methods within a UK psychology department's teaching programmes. It considers how this has contributed to the poor integration of qualitative research methods into undergraduate teaching and also considers how some key conceptual issues need to be addressed in order to facilitate student engagement with qualitative research methods. Furthermore it sets out the authors' plans to create a pragmatic approach to research methods teaching, by readdressing what they want their students to learn and how they deliver it. The authors suggest that students should be engaging with the criticisms and conceptual challenges faced by both paradigms. This is done with the overall aim of eventually creating a research methods teaching programme that focuses on creating pragmatic researchers able to use a variety of methods, regardless of whether they be quantitative or qualitative.
‘Issue-Based Research’ and ‘Process Methodology’: Reflections on a Postgraduate Master's Programme in Qualitative Methods
Authors: Bosio A. Claudio , Graffigna Guendalina
Published: May 2012

This article describes the conceptual foundation of a Master's programme in qualitative methods aimed at training professional qualitative researchers in the field of social and marketing psychology. Two principles underpin the Master's project: anchorage to research questions generated by the real social context as the driver of the entire development of the research project (i.e., ‘issue-based research’); and the adoption of what is called ‘process methodology’ as the methodological interconnection between the features of the social field (i.e., the context of the research) and of the research field (i.e., the study's scope). In practice, process methodology requires the learning of three sets of competences (content, contextual and flow) related to qualitative research. Those competences are devoted to the implementation and management of applied qualitative research able to produce situated knowledge and to enhance the transferability and usability of that knowledge. The article gives details of both the didactic structure of the programme as well as the teaching devices adopted.
Student Life; Student Identity; Student Experience: Ethnomethodological Methods for Pedagogical Matters
Authors: Attenborough Frederick , Stokoe Elizabeth
Published: May 2012

Within psychology and, more broadly, the social sciences, the teaching of qualitative methods has become a common and required component of research methods training. Textbooks and journals that support such training are increasingly dominated by various forms of individual and (focus) group interviews as methods of data collection, whilst constructionist forms of discursive psychology, particularly those influenced by conversation analysis (CA) and ethnomethodology (EM), seem to be declining. This article aims to tilt the balance in qualitative methods teaching back towards these methods, showing that and how they are uniquely able to respecify and challenge some of traditional psychology's key assumptions about ‘experience’ and ‘identity’. To do so, EM/CA methods are shown in use. Drawing upon five separate data corpora, findings from previous and ongoing research into, broadly, student identity and the ‘student experience’ of university education are presented. Rather than attempting to recover ‘identity’ and ‘experience’ from interviewee talk, the article shows how it is possible to capture it as it emerges in and as the practice of ‘doing-being-a-student-amongst-other-students’. Reflecting on these findings, the conclusion suggests that EM/CA methods should (be encouraged to) figure far more prominently in the teaching of qualitative methods in psychology.
Textbook Use and Learning: A North American Perspective
Authors: Gurung Regan A.R. , Landrum R. Eric , Daniel David B.
Published: May 2012

Eight hundred and ninety students at 35 US institutions of higher education participated in a comprehensive study of textbook use and its relation to ratings of textbook quality and helpfulness, a student self-report of learning, student self-report of their deep approach to learning, student perceptions of instructors, and a measure of quiz performance. Intercorrelations between key measures revealed surprising relationships about the influence of these variables on self-reported learning and quiz performance. An analysis of textbook differences revealed some significant differences between the books in terms of quality and helpfulness as well as self-reported learning, but not on quiz performance. The authors identified significant predictors of self-reported learning (deep approach and student perceptions of instructor) and quiz performance (grade point average and textbook helpfulness). These results highlight the complexity of examining student learning and suggest some important variables and problems for future research especially the need for a valid, reliable, measure of learning.
Combating Unintended Consequences of in-Class Revision Using Study Skills Training
Authors: Arnott Elizabeth , Dust Margaret
Published: May 2012

In order to assess the most effective means of revising course material in-class, the researchers manipulated the type of revision (spaced after each chapter versus a single, pre-exam revision) and collected exam scores, student study time estimates, and student confidence estimates. In addition, the researchers manipulated whether the class received a study skills training lecture at the beginning of the semester. Results indicated that a single, massed revision might have a counterintuitive effect, increasing student confidence, while decreasing study time and exam scores. This negative effect, however, was mitigated by a brief study skills training that highlighted the dangers of overconfidence and massed practice.
The AICPA Assurance Services Executive Committee Emerging Assurance Technologies Task Force: The Audit Data Standards (ADS) Initiative
Authors: Zhang Li , Pawlicki Amy R. , McQuilken Dorothy , Titera William R.
Published: May 2012

Data acquisition difficulties have hindered the application of advanced audit technology and audit analytics, and accentuated the challenges to meet growing audit demands. To alleviate this problem, this paper discusses the main drivers to evolve the audit process: data standards, data access, audit applications, and continuous audit. As a joint effort between the AICPA and academia, this paper provides guidance and suggestions to internal and external auditors, as well as scholars to develop knowledge for leading edge practice (Kaplan 2011).
One-Year Clinical Evaluation of Composite Restorations in Posterior Teeth: Effect of Adhesive Systems
Authors: Sundfeld RH , Scatolin RS , Oliveira FG , Machado LS , Alexandre RS , Sundefeld MLMM
Published: May 2012

This clinical study assessed the performance of posterior composite resins applied with the Adper™ Single Bond Plus (SB) and Adper™ Scotchbond SE (SE) adhesive systems and Filtek™ Supreme Plus composite resin, using modified US Public Health Service criteria. A total of 97 restorations were placed in posterior teeth by two calibrated operators. Application of the materials followed manufacturers' instructions. The restorations were evaluated by two examiners at baseline and after one year. Statistical analyses were conducted using the proportion test at a significance level of 5% (p<0.05). All the restorations evaluated (ie, 100%) received an alpha rating for the criteria of marginal discoloration and marginal integrity at baseline. At one year, for marginal discoloration, 64.6% of SB and 61.2% of SE received an alpha rating. For marginal integrity, 72.9% of SB and 77.6% of SE received an alpha rating. The other restorations received bravo ratings for both criteria. None of the teeth that received the restorative systems presented caries lesions around the restorations. A total of eight teeth presented postoperative sensitivity one week after baseline, five with SB and three with SE; the symptom had disappeared one year later. One year later, composite resin restorations using either adhesive system showed satisfactory clinical performance.
Fiber-Reinforced Framework in Conjunction with Porcelain Veneers for the Esthetic Replacement of a Congenitally Missing Maxillary Lateral Incisor: A Case Study
Authors: Benito PP , Trushkowsky RD , Magid KS , David SB
Published: May 2012

This article presents a case of a congenitally missing right maxillary lateral incisor and the contralateral incisor with discolored composite resin restorations. The technique of fiber reinforcement in conjunction with porcelain veneers was used to provide a satisfactory outcome for the patient. The key learning points of the article are the following: proper diagnosis, treatment plan and appropriate utilization of materials are mandatory for a successful result.
Ceramic Primer Heat-Treatment Effect on Resin Cement/Y-TZP Bond Strength
Authors: Silva LH , Costa AKF , Queiroz JRC , Bottino MA , Valandro LF
Published: May 2012

The purpose of this study was to evaluate the effect of different heat-treatment strategies for a ceramic primer on the shear bond strength of a 10-methacryloyloxydecyl-dihydrogen-phosphate (MDP)-based resin cement to a yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) ceramic. Specimens measuring 4.5 × 3.5 × 4.5 mm3 were produced from Y-TZP presintered cubes and embedded in polymethyl methacrylate (PMMA). Following finishing, the specimens were cleaned using an ultrasound device and distilled water and randomly divided into 10 experimental groups (n=14) according to the heat treatment of the ceramic primer and aging condition. The strategies used for the experimental groups were: GC (control), without primer; G20, primer application at ambient temperature (20°C); G45, primer application + heat treatment at 45°C; G79, primer application + heat treatment at 79°C; and G100, primer application + heat treatment at 100°C. The specimens from the aging groups were submitted to thermal cycling (6000 cycles, 5°C/55°C, 30 seconds per bath) after 24 hours. A cylinder of MDP-based resin cement (2.4 mm in diameter) was constructed on the ceramic surface of the specimens of each experimental group and stored for 24 hours at 37°C. The specimens were submitted to a shear bond strength test (n=14). Thermal gravimetric analysis was performed on the ceramic primer. The data obtained were statistically analyzed by two-way analysis of variance and the Tukey test (α=0.05). The experimental group G79 without aging (7.23 ± 2.87 MPa) presented a significantly higher mean than the other experimental groups without aging (GC: 2.81 ± 1.5 MPa; G20: 3.38 ± 2.21 MPa; G100: 3.96 ± 1.57 MPa), showing no difference from G45 only (G45: 6 ± 3.63 MPa). All specimens of the aging groups debonded during thermocycling and were considered to present zero bond strength for the statistical analyses. In conclusion, heat treatment of the metal/zirconia primer improved bond strength under the initial condition but did not promote stable bonding under the aging condition.
Cardiorespiratory, gastrointestinal, and analgesic effects of morphine sulfate in conscious healthy horses
Authors: Figueiredo Juliana P. , Muir William W. , Sams Richard
Published: May 2012

Objective—To compare the cardiorespiratory, gastrointestinal, analgesic, and behavioral effects between IV and IM administration of morphine in conscious horses with no signs of pain.

Animals—6 healthy adult horses.

Procedures—Horses received saline (0.9% NaCl) solution (IM or IV) or morphine sulfate (0.05 and 0.1 mg/kg, IM or IV) in a randomized, masked crossover study design. The following variables were measured before and for 360 minutes after drug administration: heart and respiratory rates; systolic, diastolic, and mean arterial blood pressures; rectal temperature; arterial pH and blood gas variables; intestinal motility; and response to thermal and electrical noxious stimuli. Adverse effects and horse behavior were also recorded. Plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide were measured via liquid chromatography–mass spectrometry.

Results—No significant differences in any variable were evident after saline solution administration. Intravenous and IM administration of morphine resulted in minimal and short-term cardiorespiratory, intestinal motility, and behavioral changes. A decrease in gastrointestinal motility was detected 1 to 2 hours after IM administration of morphine at doses of 0.05 and 0.1 mg/kg and after IV administration of morphine at a dose of 0.1 mg/kg. Morphine administration yielded no change in any horse's response to noxious stimuli. Both morphine-3-glucuronide and morphine-6-glucuronide were detected in plasma after IV and IM administration of morphine.

Conclusions and Clinical Relevance—Clinically relevant doses of morphine sulfate yielded minimal and short-term behavioral and intestinal motility effects in healthy horses with no signs of pain. Neither dose of morphine affected their response to a noxious stimulus.
Analysis of clinical and ultrasonographic data by use of logistic regression models for prediction of malignant versus benign causes of ultrasonographically detected focal liver lesions in dogs
Authors: Murakami Tsuyoshi , Feeney Daniel A. , Bahr Katherine L.
Published: May 2012

Objective—To investigate the value of clinical, laboratory, and imaging data for use in predicting malignant or benign histologic results for ultrasonographically detected focal liver lesions in dogs.

Sample—Records and archived images of 247 dogs evaluated at the University of Minnesota Veterinary Medical Center from 2005 to 2008 that underwent abdominal ultrasonography and histologic evaluation of the liver.

Procedures—Data were analyzed with multivariable logistic regression models. All dogs were classified as having benign or malignant liver disease on the basis of histologic reports. Three multivariable logistic regression models were fit to a development subset of the data by use of combinations of signalment, historical, physical examination, laboratory, and diagnostic imaging (survey radiography and abdominal ultrasonography) data as predictor variables. The resulting models were validated by evaluating predictive performance against a holdout validation subset of the data.

Results—Models that included ultrasonographic variables had the highest overall predictive value. In these models, greater lesion size and the presence of peritoneal fluid were the only variables that had a positive association with malignant liver disease.

Conclusions and Clinical Relevance—Large ultrasonographically detected liver lesions and the presence of peritoneal fluid were associated with malignant liver disease in dogs.
Flow cytometric evaluation of peripheral blood and bone marrow and fine-needle aspirate samples from multiple sites in dogs with multicentric lymphoma
Authors: Joetzke Alexa E. , Eberle Nina , Nolte Ingo , Mischke Reinhard , Simon Daniela
Published: May 2012

Objective—To determine whether the extent of disease in dogs with lymphoma can be assessed via flow cytometry and to evaluate the suitability of fine-needle aspirates from the liver and spleen of dogs for flow cytometric examination.

Animals—44 dogs with multicentric B-cell (n = 35) or T-cell lymphoma (9) and 5 healthy control dogs.

Procedures—Peripheral blood and bone marrow samples and fine-needle aspirates of lymph node, liver, and spleen were examined via flow cytometry. Logarithmically transformed T-cell–to–B-cell percentage ratio (log[T:B]) values were calculated. Thresholds defined by use of log(T:B) values of samples from control dogs were used to determine extranodal lymphoma involvement in lymphoma-affected dogs; results were compared with cytologic findings.

Results—12 of 245 (5%) samples (9 liver, 1 spleen, and 2 bone marrow) had insufficient cellularity for flow cytometric evaluation. Mean log(T:B) values of samples from dogs with B-cell lymphoma were significantly lower than those of samples from the same site in dogs with T-cell lymphoma and in control dogs. In dogs with T-cell lymphoma, the log(T:B) of lymph node, bone marrow, and spleen samples was significantly higher than in control dogs. Of 165 samples assessed for extranodal lymphoma involvement, 116 (70%) tested positive via flow cytometric analysis; results agreed with cytologic findings in 133 of 161 (83%) samples evaluated via both methods.

Conclusions and Clinical Relevance—Results suggested that flow cytometry may aid in detection of extranodal lymphoma involvement in dogs, but further research is needed. Most fine-needle aspirates of liver and spleen were suitable for flow cytometric evaluation.
Anxiety levels related to the type of therapy for cervical cancer
Authors: Conic Irena , Miljkovic Srbobran , Tosic-Golubovic Suzana , Stanojevic Zorica , Milenkovic Dusan , Djordjevic Biljana , Damnjanovic Ivana , Visnjic Milan , Antic Slobodan , Stefanovic Vladisav
Published: May 2012

The aim of this study was to examine the effect of treatment type on anxiety in patients with cervical cancer. Subjects and methods: This prospective study was conducted in 60 patients with cervical cancer treated by radiotherapy. The study was done before treatment, and 3 and 6 months after initial testing. For assessment of anxiety the Hamilton Anxiety Scale (HAM-A) was used.: At baseline, the values of the scale of anxiety in patients who were treated surgically were significantly higher than in patients who had been treated by radiotherapy, but the intensity of anxiety gradually decreased in both groups. In this study, pain and irregular menstrual bleeding were the most important risk factors for the development of anxiety.: Routine assessment should be introduced in clinical practice for the detection and monitoring of anxiety in all patients with cervical cancer, and a psychiatrist should be included in the multidisciplinary team for their treatment.
CD133-Positive Cells Might Be Responsible for Efficient Proliferation of Human Meningioma Cells
Authors: Tang Hailiang , Gong Ye , Mao Ying , Xie Qing , Zheng Mingzhe , Wang Daijun , Zhu Hongda , Wang Xuanchun , Chen Hong , Chen Xiancheng , Zhou Liangfu
Published: May 2012

Owing to lack of appropriate model systems, investigations of meningioma biology have come to a stop. In this study, we developed a comprehensive digestion method and defined a culture system. Using this method and system, primary meningioma cells in conditioned suspension medium and a hypoxic environment could be amplified in spheres and were passaged for more than ten generations. Meningioma sphere cells were positive for meningioma cell markers and negative for markers of neural cell types. Importantly, we found the cells expressed the stem cell marker, CD133, but not nestin. All of the tumor sphere cell populations showed a slower degree of cell proliferation than that of human glioma cells and fetal neural stem cells (NSCs). Further studies showed that the proliferative rate was positively correlated with CD133 expression. The higher the CD133 expression, the faster the cell proliferation. With the increase in cell generations, the cell proliferation rate gradually slowed down, and CD133 expression also decreased. Single CD133+ cells rather than CD133− cells could form spheres. Thus, the results above indicated that those cells expressing CD133 in spheres might be stem-like cells, which may be responsible for efficient amplification of human meningioma cells. Decreased expression of CD133 may lead to the failure of long-term passaging.
Citoyens ou étrangers ?
Authors: Mantovan Claudia
Published: May 2012

Cet article a pour objectif de réfléchir aux problématiques de citoyenneté et de différence à partir du cas de la communauté Sinti de Venise. L’augmentation de la diversité ethnique et culturelle au cœur des sociétés occidentales remet profondément en question l’idée moderne de citoyenneté, lorsque dans le même temps à l’heure de la globalisation, la crise de la politique représentative, quant à elle associée à l’augmentation de l’insécurité, provoque l’émergence de comité de citoyens « pour la sécurité ». Comment la diversité véhiculée par les Roms et les Sinti est-elle ainsi gérée en Italie ? Si au niveau national, l’exclusion semble être l’unique réponse, certaines situations locales, comme à Venise, tentent de rassembler et d’unir citoyenneté et différence par le biais de politiques de dépassement des « camps nomades ».
Le retour des villes dans la gestion de la sécurité en France et en Italie
Authors: Germain Séverine
Published: May 2012

Cet article analyse le réinvestissement, par les municipalités françaises et italiennes, de leurs compétences en matière de sécurité. À partir de l’examen comparé de quatre cas d’étude, nous suggérons que les maires agissent ainsi sous la pression de mobilisations d’habitants, qui dénoncent les désordres qui surviennent dans leur quartier. La surdité structurelle de la police nationale au traitement des désordres, les pouvoirs de police dont disposent les maires et les réformes de décentralisation qui ont renforcé leurs compétences et légitimité les incitent alors à se saisir de la régulation des désordres, un thème dès lors requalifié en enjeu sécurité par le champ politique.
Impact en Europe de l'interdiction des châtiments corporels
Authors: Bussmann Kai-D. , Erthal Claudia , Schroth Andreas
Published: May 2012

Cet exposé présente les résultats centraux d’une étude comparative européenne sur les répercussions d’une interdiction des châtiments corporels éducatifs. En Suède, en Autriche, en Allemagne, en Espagne et en France, 5000 parents ont répondu, dans le cadre d’une entrevue, à un questionnaire standardisé relatif à leur comportement éducatif, leur opinion sur les châtiments corporels ainsi que sur l’acceptation et la connaissance de la législation de leur pays à ce sujet. La question centrale était de savoir si et à quel point la codification d’une interdiction des châtiments corporels pouvait influencer le comportement éducatif des parents vis-à-vis de leurs enfants, concurremment à d’autres facteurs tels les expériences éducatives vécues par les parents dans leur enfance ou la violence au sein du couple.
Les collectivités locales en Espagne : entre continuité et rénovation
Authors: Sanz Gómez Mercedes
Published: May 2012

Résumé Dans sa première partie, l’article étudie l’évolution des Collectivités Locales en Espagne au cours de la période non démocratique (1950-1975) et du début du développement du processus décentralisateur (1978-1988). Pendant les années 90, les élus locaux ont revendiqué le besoin de renforcer l’autonomie locale au travers de la mise en place du « Pacte Local » comme voie d’une seconde ou nouvelle décentralisation. La deuxième partie traite de l’avenir des Collectivités Locales qui dépendra de l’interprétation « plus ou moins » restrictive du Pacte Local.
Les effets de territoire et de taille dans la performance industrielle : une application empirique à travers un modèle d'évaluation de la performance
Authors: March Chorda Isidre , Yagüe Perales Rosa M.
Published: May 2012

Résumé Cette étude essaie de décrire les divergences de performance dans les entreprises manufacturières appartenant à la même industrie et qui émergent d’une part, en raison de la localisation dans différentes régions et d’autre part, à cause des différences dans la taille des sociétés. À ce propos, on a développé un nouveau modèle d’évaluation de la performance, composé de 23 variables, qui a été appliqué sur un échantillon d’entreprises du secteur de l’éclairage en Espagne. L’application de techniques d’homogénéité non paramétrique nous conduit à déterminer les variables formant l’effet territoire et l’effet taille.
Distances, interactions et analyse spatiale de la ville : le cas de montréal
Authors: Charron Mathieu , Shearmur Richard
Published: May 2012

Résumé Le concept de distance demeure nébuleux malgré son omniprésence dans l’analyse géographique. Cet article s’intéresse à ce concept et aux conséquences de son ambiguïté sur l’étude de l’espace urbain. Nous y présentons certaines des principales formulations du concept de distance et discutons de leurs intérêts respectifs. Nous étudions ensuite les affinités et les différences qui marquent quelques formes de distances (distance euclidienne, distance réticulaire, distance-temps et distance d’interaction) telles que mesurées dans la région métropolitaine de Montréal. Les résultats de notre analyse empirique de Montréal démontrent que (1) les écarts entre les valeurs relatives des différentes mesures de distance sont minimes mais que (2) ces écarts représentent néanmoins des univers spatiaux distincts. Il apparaît, par exemple, que les interactions observées sont plus intenses lorsque les distances « réseau » (réticulaire et temps en transport en commun) sont plus courtes. Cependant, les interactions résiduelles (lorsque l’attractivité associée à la taille des origines et des destinations est prise en considération) sont mieux exprimées par les temps de déplacement en automobile à l’heure de pointe matinale. De telles observations confirment ainsi que les choix liés à la mesure de la distance ont un impact limité mais concret sur l’analyse spatiale intra-urbaine, car ces différentes mesures renvoient à différents univers d’interactions.
Diffusion spatiale des spillovers au sein des réseaux de recherche publics : le cas du secteur des biotechnologies en France
Authors: Gallié Emilie-Pauline
Published: May 2012

Résumé L’objectif de ce papier est de tester, grâce à une fonction de production, la dimension spatiale des spillovers au sein des réseaux publics. Ce papier étudie si la proximité géographique est une condition nécessaire à la diffusion des spillovers ou si la prise en compte des échanges entre chercheurs, davantage basés sur la proximité organisationnelle, peut également permettre cette transmission. Il apparaît que les spillovers circulent librement à travers les coopérations, au sein des réseaux publics, sans subir de contrainte spatiale.
Installations récréatives extérieures et développement économique régional : le cas des zones rurales isolées aux États-Unis
Authors: Dissart Jean-Christophe
Published: May 2012

Résumé Vu que les régions riches en aménités connaissent des niveaux de croissance plus élevés, cette étude analyse l’impact des installations récréatives extérieures sur des indicateurs de développement économique dans les zones rurales isolées aux États-Unis. Après avoir groupé les comtés en fonction de leur dotation en ressources naturelles, trois modèles de régression ont été spécifiés pour chaque cluster : évolution de l’indice de GINI, du taux de pauvreté, et du revenu des ménages sur la période 1989-99. Les résultats indiquent une relation limitée entre installations récréatives et développement économique, mais variable selon la région considérée. La principale implication en matière de politique publique est que les aménageurs ne doivent pas surestimer la contribution des installations récréatives au développement économique des zones rurales isolées.
Analyse économique des disparités écologiques spatiales : Une étude à partir des départements français
Authors: Zuindeau Bertrand
Published: May 2012

Résumé La question des disparités écologiques spatiales est une problématique relativement peu traitée. Dans cet article, nous proposons d’envisager une analyse économique des disparités environnementales en utilisant des données relatives aux départements français (données EIDER de l’IFEN). Après un traitement par analyse en composantes principales, nous transposons le modèle « STIRPAT » (YORK et al., 2003) à notre objet et le testons au travers de plusieurs équations économétriques. Les résultats mettent essentiellement en évidence le rôle majeur de la densité de population vis-à-vis des variables environnementales (pollutions atmosphériques, sites pollués, établissements à risques notamment). L’indicateur de richesse (PIB par habitant) fait apparaître, en revanche, une corrélation nettement plus faible. Une possible limite à cet exercice est l’existence de différences internes aux territoires, que masque l’utilisation de moyennes départementales. Aussi une perspective de recherche intéressante consisterait à compléter la présente analyse par une approche sur des territoires plus fins.
Comment concilier débat public et décision rationnelle ? Vers une méthode d'évaluation démocratique
Authors: Plottu Béatrice
Published: May 2012

Résumé Les conflits, qui éclatent autour de la réalisation de projets publics d’infrastructure du territoire, nous interrogent sur la capacité des outils d’aide à la décision utilisés pour anticiper ces conflits, c’est-à-dire ouvrir le choix de projet à la discussion publique. Ces conflits soulignent combien il est difficile de faire participer le citoyen au processus de prise de décision. La difficulté provient de ce que la participation du citoyen est contrainte par les fondements mêmes de la décision rationnelle qui sous-tend le calcul économique public et son outil opérationnel l’analyse coûts-avantages. Cette dernière n’a en effet pas pour objet d’organiser la confrontation des logiques d’acteurs concernés par le projet, mais de déterminer le projet assurant la meilleure allocation des ressources. C’est pourquoi, pour tenter de concilier débat public et décision rationnelle, nous avons formalisé un modèle d’évaluation démocratique qui constitue un outil d’aide à la négociation et à la décision.
Rouge et blanc : les couleurs de l'urbanité
Authors: Lacour Claude
Published: May 2012

Résumé On évoque régulièrement la crise urbaine, notamment en matière sociale mais aussi dans les domaines de la planification de l’urbanisme. Une série de questions concerne ainsi la dissolution, la disparition de l’urbanité, la perte de sens et d’identité des villes et des agglomérations où les modes de développement tendent à produire des espaces qui sont diffus et confus. Une important littérature et des pratiques locales soulignent les vertus des villages ruraux et urbains qui auraient réinventé l’urbanité et sauraient la faire revivre. À partir des observations concernant des fêtes estivales de quelques villes du Sud-Ouest, on tente d’analyser et de théoriser, de manière interrogative une urbanité rurale dont les couleurs symboliques et identitaires seraient le Rouge et le Blanc.
Les clusters vitivinicoles français à AOC
Authors: Calvet Jacques
Published: May 2012

Résumé Ce texte a pour objet d’analyser certains des problèmes actuels de l’industrie vitivinicole française d’appellation en utilisant les concepts de cluster et de bien club. Nous avançons l’idée que les régions vitivinicoles françaises sont organisées en clusters et qu’à ce titre elles tirent leurs avantages compétitifs d’une combinaison en leur sein des formes de coordination marchandes (la concurrence) et non marchandes (la coopération), le résultat principal de la coopération étant la mise en place d’un bien club spécifique à l’agriculture et en particulier à la vitiviniculture, l’Appellation d’Origine Contrôlée. Ces caractéristiques structurelles impliquent deux sources de dysfonctionnement: des comportements opportunistes qui nuisent à la qualité du produit et une complexification de l’offre qui trouble l’information transmise au consommateur. Ces dysfonctionnements affaiblissent la vitiviniculture française par rapport aux producteurs du « Nouveau monde » sur les marchés d’exportation. En conclusion, nous proposons des pistes de sortie de crise déduites logiquement de notre analyse.
Les jeunes adultes migrants de retour : une vitalité pour les régions
Authors: Potvin Dominique
Published: May 2012

Résumé THE YOUNG ADULTS RETURN MIGRANTS : AN ENERGY FOR REGIONS Dynamisme, créativité, implication, voici plusieurs qualités qui sont régulièrement mises de l’avant par les organisations vouées au développement. Des jeunes migrants semblent détenir plusieurs de ces qualités, particulièrement ceux qui reviennent dans leur milieu d’origine. Ces qualités sont ressorties en comparant les migrants de retour avec les individus qui ne sont jamais partis de leur région. Cette comparaison s’est faite sur la base des projets qu’ils ont réalisés, de leur implication dans leur milieu et de leur intérêt face à leur environnement de vie. La recherche réalisée au Québec montre que les migrants de retour, dans les régions les plus éloignées des grands centres urbains, se sont révélés des acteurs importants dans leur milieu de vie et, de ce fait même, peuvent contribuer au développement de leur collectivité et de leur région .
Éléments sur la géographie de l'agriculture aux États-Unis et dans l'Union Européenne : les productions agricoles se concentrent-elles ?
Authors: Daniel Karine
Published: May 2012

Résumé Dans cet article nous caractérisons les processus de concentration géographique des productions agricoles et de spécialisation des bassins de production aux Etats-Unis et dans l’Union européenne pour une période récente. Nous cherchons à déterminer ensuite si la concentration observée s’effectue dans les bassins de production les mieux situés par rapport aux bassins de consommation.