bluuebunny/crossref_metadata_2025 huggingface dataset:
Vascular Access Type and Changes in Infammatory Markers in Incident Dialysis Patients: A Pilot Study
Authors: Sachdeva Mala , Kovalchuk Oleksander , Bitzer Markus , Mokrzycki Michele Helene
Published: January 2018

Purpose

To determine the association between the initial hemodialysis (HD) vascular access type and short-term changes in inflammation markers.

Methods

This is a prospective, observational study in incident chronic kidney disease (CKD) (stages 4 and 5) patients receiving their first HD vascular access. Serum samples were obtained pre-access placement, and 1 week, and 1 month post-access insertion. Samples were tested for high sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) using ELISA. Patients with known inflammatory states (infection, malignancy, connective tissue disorders, organ transplantation and those on immune modulating agents) were excluded. The hsCRP and IL-6 values were transformed into logarithmic scale. Chi-square analysis, independent and paired t-tests were performed where appropriate, and a two-way ANOVA with time as a repeated measure was also performed. Significance was determined at p=0.05.

Results

One-month follow-up data was obtained in 48 patients (arteriovenous fistula (AVF), n=10; tunneled catheter (TC), n=28; arteriovenous graft (AVG), n=10). A significant increase in both hsCRP (p<0.05) and IL-6 (p=0.02) occurring 1 week after TC insertion was observed. Elevation of the IL-6 levels appeared to be sustained 1 month after TC insertion, although this finding was not statistically significant (p=0.68), whereas the hsCRP levels returned to baseline within 1 month. After AVG insertion only the hsCRP levels rose significantly (p=0.01) after 1 week and returned to baseline within 1 month. In the AVF group, inflammatory markers did not change for any time period.

Conclusions

In CKD patients, TC and AVG insertion result in a transient state of inflammation 1 week post-operatively, which is not observed after AVF surgery. Whether this is a persistent phenomenon after TC insertion requires a larger, longitudinal study.
Using Watershed Boundaries to Map Adverse Health Outcomes: Examples From Nebraska, USA
Authors: Corley Brittany , Bartelt-Hunt Shannon , Rogan Eleanor , Coulter Donald , Sparks John , Baccaglini Lorena , Howell Madeline , Liaquat Sidra , Commack Rex , Kolok Alan S
Published: January 2018

In 2009, a paper was published suggesting that watersheds provide a geospatial platform for establishing linkages between aquatic contaminants, the health of the environment, and human health. This article is a follow-up to that original article. From an environmental perspective, watersheds segregate landscapes into geospatial units that may be relevant to human health outcomes. From an epidemiologic perspective, the watershed concept places anthropogenic health data into a geospatial framework that has environmental relevance. Research discussed in this article includes information gathered from the literature, as well as recent data collected and analyzed by this research group. It is our contention that the use of watersheds to stratify geospatial information may be both environmentally and epidemiologically valuable.
Longitudinal personality change associated with cognitive decline in multiple sclerosis
Authors: Roy Shumita , Drake Allison , Fuchs Tom , Dwyer Michael G , Zivadinov Robert , Chapman Benjamin P , Weinstock-Guttman Bianca , Benedict Ralph HB
Published: January 2018

We previously reported that personality and cognition were stable over 3 years in patients with multiple sclerosis (MS). This study examined whether a longer duration would reveal evidence of emerging personality dysfunction. The NEO Five-Factor Inventory and Brief International Cognitive Assessment for MS was used to assess personality and cognition, respectively. Patients were classified as “Cog Stable” or “Cog Decline” based on cognitive deterioration over 5 years. Extraversion and Conscientiousness declined across pooled groups. Follow-up of a group by time interaction found that decline in these traits was more evident in the Cog Decline group, demonstrating a link between personality and cognitive change.
Becoming a personal style blogger: Changing configurations and spatialities of aesthetic labour in the fashion industry
Authors: Brydges Taylor , Sjöholm Jenny
Published: January 2018

The increasing pervasiveness of social media and digital technology has had a particular impact on the geographies and nature of work in the fashion industry. A new segment of entrepreneurs – fashion bloggers – are utilizing these digital technologies, such as blogs and social media, to transform their personal lives and style into online businesses. This article draws on an in-depth case study analysis of an American personal style fashion blog; tracing its nine-year evolution from an ‘outfit-of-the-day’ personal style blog, to one that encompasses her entire personal life, including diets, fitness, home décor and pregnancy. By focusing on one blog, we provide an in-depth exploration from its roots as a hobby for personal expression to a means of full-time employment in the fashion industry. Through this examination, emphasis is given to the process of becoming a blogger and the intensification of the ways in which the self is presented and commodified over time. We argue that personal style fashion bloggers provide an illustrative case study, not only for expanding our understanding of aesthetic labour in the digital age, but also highlighting the spaces and temporalities of work that these new formations and engagements of work give rise to. These processes highlight the changing configurations and spatialities of aesthetic labour online.
Diffusing gender equality norms in the midst of a feminicide pandemic: The case of AMEXCID and decentralized Mexican South-South cooperation
Authors: Sørensen Ninna Nyberg
Published: January 2018

Mexican development policy is guided by the country’s dual function as both a recipient and a provider of international cooperation. Over the past 17 years, the country has taken several initiatives to promote gender equality nationally, and today gender equality norms cut across Mexican priorities in foreign policy and South-South cooperation activities. Paradoxically, the gains achieved at policy formulating tables have been accompanied by a rise in gender-based violence. To approach this paradox, this article engages with gender equality norms to show how they have been introduced, developed and transformed in the context of a national security crisis and extreme violence directed at women. The analysis points to the important role of Mexican feminists and anti-feminicide activists in the promotion of gender equality norms, as well as to the existence of a political landscape in which structural inequality persists and such norms remain highly contested.
Challenges and issues facing ethnic minority small business owners
Authors: Rahman Md Zillur , Ullah Farid , Thompson Piers
Published: January 2018

Studies investigating the challenges and barriers faced by ethnic minority entrepreneurs have often concentrated on areas where there is a large supportive ethnic minority community. Less work has been conducted on the experience of those entrepreneurs operating in cities where such ethnic resources may be less widely available. Considered from the perspective of mixed embeddedness framework, this study uses face-to-face interviews with 25 ethnic minority entrepreneurs to gain a greater understanding of the constraints experienced by the starting and running businesses in one such location, the Scottish city of Aberdeen in the United Kingdom. Although issues found by previous studies such as access to funding remain an issue, the entrepreneurs indicated problems with access to labour as United Kingdom Border Agency’s immigration rules and tightening of the Post Study Work visa have had a profound effect on these entrepreneurs. The results imply that the weakening of the ethnic resource microsphere has not opened up opportunities which are exploited by the entrepreneurs, but they have still been exposed to external forces from the regulatory macrosphere. Both entrepreneurs and policymakers need to think carefully about the retention, training and recruitment of staff. In particular, the wider ramifications of immigration rule changes need to be considered, but also whether entrepreneurs need to be more open to the potential of recruiting non-ethnic employees and if so what support is required to achieve this.
The practical implementation of methanol as a clean and efficient alternative fuel for automotive vehicles
Authors: Sun Harold , Wang Wesley , Koo Kim-Pui
Published: January 2018

Ever since the energy crises in 1970s, the methanol, among other alternative fuels, has been studied for automotive application. The methanol has been widely used for auto racing due to its superior anti-knock characteristics. However, aldehyde is a highly toxic pollutant and aldehyde emission out of alcohol fuel combustion could be considerably higher than spark-ignited gasoline engines. The corrosion and durability of methanol fuel components were also concerns for mass production of methanol-fueled vehicles. The authors have worked with an automotive manufacturer in China to investigate the brake thermal and emission improvement potentials of a methanol-fueled, spark-ignited engine over the original gasoline engine on a passenger car application and to demonstrate the performance and China V emission compliance over its useful life of 160,000 km. The study found that the methanol-fueled engine has 4%–6% brake thermal advantage over the original gasoline engine, and a three-way oxidation catalyst has successfully managed the tailpipe emissions under China V emission limit, consistently over the journey of 160,000 km. The test data show that the tailpipe aldehyde emission is actually reduced to a level that is below what is required by US LEV III emission standard, largely due to the three-way oxidation catalyst and the gasoline cold start assistance at the beginning of the transient emission cycle. This study indicates that methanol-fueled engine might be an attractive low-cost alternative for a more efficient and clean powertrain over conventional gasoline when a light-duty diesel engine faces challenges from future China VI emission regulations.
The ethics of commercial human smuggling
Authors: Müller Julian F.
Published: January 2018

Even though human smuggling is one of the central topics of contention in the political discourse about immigration, it has received virtually no attention from moral philosophy. This article aims to fill this gap and provide a moral analysis of commercial human smuggling. The article accomplishes this by analyzing whether the moral outrage against human smugglers during the European refugee crisis can be justified. To do this, the article first analyzes whether (commercial) human smuggling is inherently wrong. Answering this question in the negative, this article then asks whether the wholesale condemnation of human smuggling in the European case can nevertheless be justified by recourse to a nation-state’s purported right to political self-determination.
Tangible topographic modeling for landscape architects
Authors: Harmon Brendan A , Petrasova Anna , Petras Vaclav , Mitasova Helena , Meentemeyer Ross
Published: January 2018

We present Tangible Landscape—a technology for rapidly and intuitively designing landscapes informed by geospatial modeling, analysis, and simulation. It is a tangible interface powered by a geographic information system that gives three-dimensional spatial data an interactive, physical form so that users can naturally sense and shape it. Tangible Landscape couples a physical and a digital model of a landscape through a real-time cycle of physical manipulation, three-dimensional scanning, spatial computation, and projected feedback. Natural three-dimensional sketching and real-time analytical feedback should aid landscape architects in the design of high performance landscapes that account for physical and ecological processes. We conducted a series of studies to assess the effectiveness of tangible modeling for landscape architects. Landscape architecture students, academics, and professionals were given a series of fundamental landscape design tasks—topographic modeling, cut-and-fill analysis, and water flow modeling. We assessed their performance using qualitative and quantitative methods including interviews, raster statistics, morphometric analyses, and geospatial simulation. With tangible modeling, participants built more accurate models that better represented morphological features than they did with either digital or analog hand modeling. When tangibly modeling, they worked in a rapid, iterative process informed by real-time geospatial analytics and simulations. With the aid of real-time simulations, they were able to quickly understand and then manipulate how complex topography controls the flow of water.
Entwining a Conceptual Framework
Authors: De Angelis Romina
Published: January 2018

This article proposes a theoretical framework for research and pedagogy development in the context of education for sustainable development (ESD). It combines transformative learning theory with elements drawn from Buddhist and other Eastern spiritual perspectives. Firstly, it outlines the ESD context and its current gaps. Secondly, it analyzes relevant aspects of transformative learning as an educational theory in relation to ESD. Thirdly, it explores how the notions of “inner experience,” “oneness of reality,” “moral sustainable values,” and “community curriculum” arise by interweaving Buddhist/Eastern spiritual approaches with transformative learning to devise a conceptual framework. Fourthly, it presents a brief section outlining a suitable methodology for bridging together differing paradigms including its challenges and potential benefits. Finally, it considers the possible impact of said theoretical framework for innovative research and pedagogies related to sustainable learning in the Global South and internationally.
Utility of Expert Cue Exposure as a Mechanism to Improve Decision-Making Performance Among Novice Criminal Investigators
Authors: Morrison Ben W. , Wiggins Mark W. , Morrison Natalie M. V.
Published: January 2018

The research tested whether systematic exposure to expert-identified cues would improve novice criminal investigators’ cue recognition and, in turn, decision making. Two studies are reported, the first of which was a pre- to postexposure assessment of 20 novices’ cue recognition. This involved testing novices’ recognition (accuracy and latency) of pairings of text-based labels (elicited via cognitive task analyses with subject matter experts) prior to and following an exposure phase. The results revealed statistically significant improvements in comparison with a control group. In the second study, an assessment of 36 novices’ decision-making performance was undertaken prior to and following cue-based exposure (either expert or control cues). Participants engaged one of two decision tasks, which varied in the level of decision support offered: high (i.e., most pertinent features were highlighted for users) or low (i.e., features were naturally “embedded” in the task environment). Although participants receiving expert cue exposure demonstrated improvements in decision-making efficiency, advances in accuracy could be established only where a high level of support was offered. It was concluded that expert cue exposure can offer opportunities for learner development; however, a combination of exposure programs and decision support systems offers the greatest potential in improving the situation assessment skills of less experienced investigators.
Women in Policing and the Response to Rape: Representative Bureaucracy and Organizational Change
Authors: Schuck Amie M.
Published: January 2018

The purpose of this study is to evaluate the theory of representative bureaucracy. Cross-sectional and longitudinal data, covering a period from 1997 to 2013, suggest that a greater number of women in the policing workforce is related to higher reporting rates for rape incidents and higher clearance rates for rape cases. Furthermore, the findings suggest that the relationship between female representation and women-centered outcomes is moderated by the presence of a union and mediated by resources for victims and community policing. Looking ahead, more research is needed to identify how female representation in policing influences organizational processes and outcomes for citizens.
Clinical Application of Mathematical Long Bone Ratios to Calculate Appropriate Donor Limb Lengths in Bilateral Upper Limb Transplantation
Authors: Lutfy Justyn , Pietak Alexis , Mendenhall Shaun D. , Neumeister Michael W.
Published: January 2018

Background: Limited methods exist to aid in deciding the appropriate donor limb lengths in bilateral upper limb amputees qualifying for vascularized composite allotransplantation. We hypothesized mathematical equations could be created using long bone length ratios, and applied to radiographs, to approximate the patient’s limb length prior to amputation. Methods: A data set of 30 skeletons’ unilateral upper limb long bones measured using osteometric board and calipers was used. Anatomic segment ratios were calculated based on humerus length after multivariate linear regression analysis. For clinical application testing, 5 cadavers’ upper limbs were radiographed. Radiographic bone lengths were then measured along the long axis of each long bone. These measured radiographic lengths were then compared with the predicted bone lengths, generated from the skeleton data set ratios, for each cadaver. Results: The chi-square goodness-of-fit test showed excellent fit ( P < .01) between the predicted and radiographically measured lengths for the 5 cadavers, and interobserver measurements showed no statistical difference. Depending on the cadaver, percent error in total limb length predicted to measure ranged from 0.9% to 2.7%. The variables to multiply an individual humerus length to calculate a given anatomic segment thus proved to be effective. Conclusions: If a bilateral upper limb amputee has 1 intact humerus, ratios to the humerus length can be reliably applied to calculate the preamputation limb length based on the patient’s radiographic humerus length. These formulas are indicated for finding the appropriate limb lengths, and smaller anatomic segments, for donor-recipient matching in upper limb transplantation.
The Prognostic Value of Hormone Receptor Detection by Enzyme Immunoassay and Immunohistochemistry: A Prospective Study in Patients with Early Breast Cancer
Authors: Fiets W.E. , Blankenstein M.A. , Struikmans H. , Ruitenberg H.M. , Nortier J.W.R.
Published: January 2018

The main reason to determine estrogen (ER) and progesterone receptors (PR) in breast cancer is their predictive value for the response to endocrine therapy. In addition, ER and PR are often used as prognostic indicators. Enzyme immunoassay (EIA) and immunocytochemical assay (ICA) are two methods for determining ER and PR. These two methods have not been compared with each other in relation to clinical endpoints. In the present study we prospectively evaluated the prognostic value of ER and PR as determined by ICA and EIA in 223 and 207 patients, respectively, with early breast cancer. ER was positive in approximately 77% of patients, while PR was positive in approximately 65% of patients. The proportion of potential agreement beyond chance between EIA and ICA was 0.58 and 0.65 for ER and PR, respectively. The median follow-up was 86 months. Both ER and PR appeared to be weak prognostic factors. There were no differences in prognostic value according to the time point of analysis or cutoff value chosen, nor were there any differences in the prognostic value of hormone receptors detected by ICA or EIA. Both methods appear to be equivalent in terms of qualification and prognostic value.
The Half-Life of Thymidine Kinase 1 in Serum Measured by ECL Dot Blot: A Potential Marker for Monitoring the Response to Surgery of Patients with Gastric Cancer
Authors: Zou L. , Zhang P.-G. , Zou S. , Li Y. , He Q.
Published: January 2018

Thymidine kinase 1 in serum (STK1) of patients with gastric cancer was determined by two methods: ECL dot blot and radioactivity assay. Both measurements showed significantly different values for preoperative STK1 and healthy STK1 (p=0.012 for ECL dot blot and p=0.003 for the radioactivity assay). The preliminary results of ECL dot blot STK1 measurement showed that in tumor-free subjects the level of the enzyme was significantly reduced to 52.7% 35 days after surgery (n=8, p=0.0106). The decrease in STK1 levels in the tumor-free subjects paralleled the decline of the half-life of the STK1 enzyme. In patients with distant metastases (n=6) the enzyme level had increased to 173% 35 days postoperatively. By contrast, with the radioactivity assay no significant differences in thymidine kinase activity for 0-day-postoperative patients and 35-day-postoperative tumor-free patients was found (p=0.329). The activity decreased to 80% in 35-day-postoperative patients with metastatic disease. We suggest that the value of the half-life of STK1 measured by ECL dot blot can be used as a potential marker for monitoring the response to surgery in patients with gastric or other cancers one month after surgery.
Prognostic Significance of Tissue-Type Plasminogen Activator (tPA) Content in Gastric Cancer and Surrounding Mucosa
Authors: Sanz L. , Vizoso F. , Vérez P. , Allende M.T. , Corte M.G. , Abdel-Lah O. , Martín A. , García-Muñíz J.L.
Published: January 2018

Aims

We analyzed the tPA content in primary gastric carcinomas and surrounding mucosa in order to assess the relationship between tPA content, clinicopathological tumor characteristics, and estrogen and progesterone receptor content. We evaluated the prognostic value of this serine protease in gastric cancer patients.

Patients and methods

122 resected gastric neoplasms and 95 adjacent mucosa samples were studied. The tPA content was measured in cytosol by an ELISA method. Cytosolic ER and PgR were measured with a solid phase enzyme immunoassay.

Results

Cytosolic tPA levels in neoplastic tissues (median 1.0 ng/mg prot) were significantly lower (p=0.002) than those found in paired mucosa samples (median 2.3 ng/mg prot). There was no significant association between tPA levels and clinicopathological parameters or PgR content, but tPA levels were significantly correlated with ER content. The intermediate-tPA-content group, corresponding to samples with between 0.3 and 1.70 ng/mg protein, proved to have a significantly high risk of relapse.

Conclusions

We found a wide variability in tPA levels in gastric carcinoma and adjacent mucosa samples, with significantly decreased levels in tumors and a significantly positive relationship between tPA levels and ER status. There was a non-monotonic relationship between tPA levels and prognosis in patients with gastric cancer.
Medullary Breast Carcinoma: Prognostic Implications of P53 Expression
Authors: Dendale R. , Vincent-Salomon A. , Mouret-Fourme E. , Savignoni A. , Medioni J. , Campana F. , Vilcoq J.R. , De La Rochefordière A. , Soussi T. , Asselain B. , De Cremoux P. , Fourquet A.
Published: January 2018

Medullary breast carcinoma (MBC) is a rare pathological type of breast cancer. The rate of p53 protein accumulation is higher in MBC than in common invasive ductal carcinoma. Whether this particular feature of MBC influences the outcome after treatment is unknown. We retrospectively analyzed the characteristics, treatment and outcome of 71 patients with MBC treated between 1981 and 1996. The median age was 51 years (range 27–81) and the median clinical tumor size was 25 mm (range 0-70 mm). Breast-conserving treatment was offered when possible: 55 patients had undergone a tumorectomy and radiotherapy while 16 patients had undergone a mastectomy. p53 protein accumulation was determined by immunohistochemistry on paraffin-embedded tumor specimens from 58/71 samples available for this study. The median follow-up for the 56 survivors was 113 months (range 30–241). The 10-year survival and metastasis-free survival rates were 81% and 81.4%, respectively. The local recurrence rate was 16.4%. The two factors predicting outcome were pathological axillary node involvement in the 60 patients who underwent axillary dissection and adjuvant chemotherapy. p53 accumulation was found in 33/58 patients (57%). p53 status was not predictive of survival nor of distant or local recurrences. We confirm that medullary breast carcinoma has a favorable prognosis despite its aggressive pathological features. p53 protein accumulation, found in the majority of MBCs, was not related to outcome.
Assessment of the Value of Preoperative Serum Levels of CA 242 and CEA in the Staging and Postoperative Survival of Colorectal Adenocarcinoma Patients
Authors: Kim S.B. , Fernandes L.C. , Saad S.S. , Matos D.
Published: January 2018

Introduction

CEA is the most frequently used tumor marker in colorectal cancer. There may be an improvement in its efficacy when used in association with CA 242.

Aim

The purpose of this study was to evaluate the efficacy of preoperative serum levels of the tumor markers CA 242 and CEA in the staging and postoperative follow-up of colorectal adenocarcinoma patients.

Patients and Methods

Of a series of 134 patients with colorectal adenocarcinomas 90 underwent radical surgery and 44 palliative surgery. The control group consisted of 22 organ donors. The cutoff serum levels utilized were 5 ng/mL for CEA and 20 U/mL for CA 242. The mortality during follow-up was recorded in order to determine the duration of survival. The data were submitted to statistical analysis using diagnostic tests, the chi-square test, survival analysis (Kaplan and Meier) and ROC curves. A significance level of p ≤ 0.05 was applied.

Results

The sensitivity of CEA in Dukes’ stages A, B, C and D was 27.8%, 32.4%, 32.1% and 66.7%, respectively. The sensitivity of CA 242 was 11.1%, 16.2%, 30.8% and 50%. When both markers were combined, the sensitivity was 33.3%, 48.6%, 40.7% and 72.5%. In the group of patients who underwent radical surgery the mean survival was 60.47 months for those with high preoperative CEA levels, 52.22 months for those with high preoperative CA 242 levels, and 44.80 months for those with elevated levels of both markers. There was a statistically significant difference in survival between patients undergoing radical surgery with elevated CA 242 levels, especially when CEA was also elevated, and patients without elevated CA 242.

Conclusion

Preoperative serum levels of CA 242 showed less efficacy than CEA levels for the staging of colorectal adenocarcinoma patients. Elevated preoperative serum levels of CA 242 alone were related to poor survival, especially in association with high levels of CEA.
Cytosolic Levels of Neuron-Specific Enolase in Squamous Cell Carcinomas of the Lung
Authors: Ruibal A. , Nuñez M.I. , Rodríguez J. , Jiménez L. , Del Rio M.C. , Zapatero J.
Published: January 2018

To study the behavior and possible correlations of neuron-specific enolase (NSE) with other clinicobiological parameters, we measured the cytosolic levels of this marker by means of an immunoradiometric assay (IRMA) in 95 squamous cell lung carcinoma samples. We also analyzed the levels of pS2, tissue-type plasminogen activator (t-PA), hyaluronic acid (HA), free beta subunit of human chorionic gonadotropin (β-HCG), CYFRA 21.1 and CA 125 in cytosol. On the cell surface we analyzed the concentrations of epidermal growth factor receptor (EGFR), HA, erbB-2 oncoprotein, CD44s, CD44v5 and CD44v6. Other parameters considered were clinical stage, lymph node involvement, histological grade (HG), ploidy and the cellular S-phase fraction measured by flow cytometry on nuclei obtained from fresh tissues.

In the 95 squamous cell carcinomas the cytosolic levels of NSE varied from 4.5 to 2235 ng/mg protein (median: 267) and were significantly higher (p<0.001) than those observed in 38 samples of normal pulmonary tissue obtained from the same patients (range: 56–657; median: 141.5). When classifying tumors according to the different parameters analyzed, we observed that the levels of NSE were higher in aneuploid than in diploid cases (p=0.046) and in those that were HG3 than in those that were HG2 (p<0.001). Tumors with high NSE levels (>422 ng/mg protein; 75th percentile) were more likely to have high S-phase values (p=0.012) and were more frequently aneuploid (p=0.038) and HG3 (p<0.001) than those with low levels of NSE (<180 ng/mg protein; 25th percentile).

These results lead us to the following conclusions: 1) the cytosolic concentrations of NSE are significantly higher in squamous cell carcinomas than in healthy pulmonary tissue, and 2) the cytosolic concentrations of NSE are not correlated with clinical stage or nodal involvement. However, in our study higher levels of the enzyme were statistically correlated with aneuploidy, histological grade 3 and S-phase. This may explain its association with poorer outcome and progression, but also the more favorable response of tumors with elevated NSE to chemotherapy, as suggested by other groups.
Are 90K/MAC-2BP Serum Levels Correlated with Poor Prognosis in HCC Patients? Preliminary Results
Authors: Iacovazzi P.A. , Guerra V. , Elba S. , Sportelli F. , Manghisi O.G. , Correale M.
Published: January 2018

In this study we assessed the prognostic significance of 90K/MAC-2BP serum levels in a group of 40 hepatocellular carcinoma patients. This glycoprotein is a new, interesting serum marker that reflects the immune reaction of the host against certain viral infections and tumors such as breast, ovarian and pancreatic cancer. Hepatocellular carcinoma (HCC) is one of the most widespread tumors in the world. AFP is currently the most useful marker for HCC, in spite of its poor diagnostic sensitivity. In this study 40 cirrhotic HCC patients were enrolled. The prevalence of viral hepatic infections in this group was 73% for HCV, 8% for HBV, and 8% for both viruses. Thirteen percent of the patients showed non-virus-related liver damage. 90K serum levels were assayed by an ELISA kit and AFP levels by a chemiluminescent enzyme immunometric system. The overall survival curves were estimated by the Kaplan-Meier method, taking into account age, sex, 90K and AFP serum levels. Statistical analysis showed a highly significant influence on overall survival of age below 70 years and 90K serum levels below the cutoff of 14 ng/mL. Serum AFP (≤20 ng/mL) had positive prognostic value only when it was associated with 90K levels (p<0.02, log-rank).
Clinical Utility of Hyperglycosylated hCG in Serum Taken before Hydatidiform Mole Evacuation to Predict Persistent Trophoblastic Disease
Authors: Duc H. Ngo , van Trommel N.E. , Sweep F.C.G.J. , Massuger L.F.A.G. , Thomas C.M.G.
Published: January 2018

Objective

Human chorionic gonadotropin (hCG) is widely used in the management of hydatidiform mole and persistent trophoblastic disease (PTD). Studies on hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen, ITA) in PTD are limited. In serum samples taken before evacuation of molar pregnancies we measured the concentrations of free hCG β-subunit (free hCGβ), “total” hCG (hCG+hCGβ) and ITA, and determined whether ITA, the two other hCG analytes, or the calculated ratios of hCGβ/hCG+hCGβ, hCGβ/ITA and hCG+hCGβ/ITA could predict the later development of PTD.

Design

A retrospective study based on blood specimens collected in the Dutch Central Registry for Hydatidiform Moles. The study group comprised 97 patients with hydatidiform moles who did not develop PTD after mole evacuation and 33 patients who did develop PTD.

Methods

Serum samples from 130 patients with hydatidiform mole with or without PTD were assayed using specific (radio)immunoassays for free hCGβ, total hCG, and ITA. From these analytes we also calculated the ratios hCGβ/hCG+hCGβ, hCGβ/ITA, and hCG+hCGβ/ITA. To predict the development of PTD from these analytes and parameters we performed receiver-operating characteristic (ROC) curve analysis, resulting in areas under the curve (AUCs) that represented the diagnostic accuracy which was rated in a range from excellent (AUC >0.9 or <0.1) to poor (AUC 0.4–0.6).

Results

The diagnostic accuracy of ITA was moderate (0.618) and not different from that of free hCGβ (0.610) and hCG+hCGβ (0.622).

Conclusions

ITA as well as the other analytes and parameters in serum taken prior to evacuation from patients with molar pregnancies cannot be used to predict the subsequent development of persistent trophoblastic disease.
p53 Expression in Leukoplakia and Carcinoma of the Tongue
Authors: Vora H.H. , Trivedi T.I. , Shukla S.N. , Shah N.G. , Goswami J.V. , Shah P.M.
Published: January 2018

There is growing interest in assessing multistep carcinogenesis and predicting its course using different molecular markers. TP53 is a tumor suppressor gene and appears to be one of the molecular targets of tobacco-related carcinogens in oral cancer. The present study evaluated the role of p53 expression in patients with leukoplakia and carcinoma of the tongue. p53 expression was studied by immunohistochemistry. All patients with leukoplakia of the tongue were male tobacco users. Nuclear staining of p53 was observed in 79% of those patients. Fifty percent, 25% and 4% of the patients expressed 1+, 2+ and 3+ nuclear staining, respectively. When leukoplakia patients were graded according to histopathology, 67% had hyperplasia and 33% had dysplasia. Nuclear p53 accumulation was 88% in hyperplasia and 62% in dysplasia. In patients with tongue cancer, nuclear accumulation of p53 was seen in only 19% of the tumors, with a staining intensity of 1+ in 13%, 2+ in 2% and 3+ in 4% of the tumors. The prevalence of nuclear p53 positivity (79%) was significantly higher in patients with leukoplakia than in patients with tongue cancer (19%; χ2 = 34.32, r = –0.45, df = 1, p = 0.0001; odds ratio (OR) = 16.66, 95% CI, 5.25–52.86). Therefore, leukoplakia patients who show p53 expression have a higher risk of developing tongue cancer than those who do not show p53 expression. As the percentage of positivity of nuclear p53 was very low, none of the clinicopathological parameters or disease status showed any significant association with it. The interesting finding is that none of the female cancer patients showed nuclear p53 expression. Therefore, p53 accumulation is believed to be an early event in neoplastic progression of the tongue.
Identification of Differentially Expressed Genes in Prostatic Epithelium in Relation to Androgen Receptor CAG Repeat Length
Authors: Coutinho-Camillo C.M. , Miracca E.C. , Dos Santos M.L. , Salaorni S. , Sarkis A.S. , Nagai M.A.
Published: January 2018

The CAG repeat within exon 1 of the androgen receptor (AR) has been associated with the development of prostate cancer. The shorter number of glutamine residues in the protein has been associated with a higher transcriptional activity of the AR and increased relative risk for prostate cancer. In an attempt to identify differentially expressed genes in prostate cancer in relation to AR CAG repeat length variation, in this study we used total mRNA from normal and tumor tissues from 2 prostate cancer patients with AR alleles containing 19 and 26 CAG repeats to perform differential-display RT-PCR analysis. We were able to identify 48 different transcripts that showed homology to several known genes associated with different biological pathways. Among the differentially expressed genes, ATRX and SFRP1 were further validated by quantitative RT-PCR. The transcripts of both ATRX and SFRP1 genes proved to be down-regulated in most of the prostate tumors analyzed by quantitative RT-PCR. Hypermethylation of the promoter region of the SFRP1 gene was found in 17.5% (7/40) of the cases analyzed and was associated with the loss of SFRP1 expression (p=0.014). The differentially expressed genes identified in this study are implicated in several cellular pathways that, when up- or down-regulated, might play a role in the tumorigenic process of the prostate.
Use of online recruitment strategies in a randomized trial of cancer survivors
Authors: Juraschek Stephen P , Plante Timothy B , Charleston Jeanne , Miller Edgar R , Yeh Hsin-Chieh , Appel Lawrence J , Jerome Gerald J , Gayles Debra , Durkin Nowella , White Karen , Dalcin Arlene , Hermosilla Manuel
Published: January 2018

Background/Aims:

Despite widespread Internet adoption, online advertising remains an underutilized tool to recruit participants into clinical trials. Whether online advertising is a cost-effective method to enroll participants compared to other traditional forms of recruitment is not known.

Methods:

Recruitment for the Survivorship Promotion In Reducing IGF-1 Trial, a community-based study of cancer survivors, was conducted from June 2015 through December 2016 via in-person community fairs, advertisements in periodicals, and direct postal mailings. In addition, “Right Column” banner ads were purchased from Facebook to direct participants to the Survivorship Promotion In Reducing IGF-1 Trial website. Response rates, costs of traditional and online advertisements, and demographic data were determined and compared across different online and traditional recruitment strategies. Micro-trials optimizing features of online advertisements were also explored.

Results:

Of the 406 respondents to our overall outreach efforts, 6% (24 of 406) were referred from online advertising. Facebook advertisements were shown over 3 million times (impressions) to 124,476 people, which resulted in 4401 clicks on our advertisement. Of these, 24 people ultimately contacted study staff, 6 underwent prescreening, and 4 enrolled in the study. The cost of online advertising per enrollee was $794 when targeting a general population versus $1426 when accounting for strategies that specifically targeted African Americans or men. By contrast, community fairs, direct mail, or periodicals cost $917, $799, or $436 per enrollee, respectively. Utilization of micro-trials to assess online ads identified subtleties (e.g. use of an advertisement title) that substantially impacted viewer interest in our trial.

Conclusion:

Online advertisements effectively directed a relevant population to our website, which resulted in new enrollees in the Survivorship Promotion In Reducing IGF-1 Trial at a cost comparable to traditional methods. Costs were substantially greater with online recruitment when targeting under-represented populations, however. Additional research using online micro-trial tools is needed to evaluate means of more precise recruitment to improve yields in under-represented groups. Potential gains from faster recruitment speed remain to be determined.
The SAGE Model of Social Psychological Research
Authors: Power Séamus A. , Velez Gabriel , Qadafi Ahmad , Tennant Joseph
Published: January 2018

We propose a SAGE model for social psychological research. Encapsulated in our acronym is a proposal to have a synthetic approach to social psychological research, in which qualitative methods are augmentative to quantitative ones, qualitative methods can be generative of new experimental hypotheses, and qualitative methods can capture experiences that evade experimental reductionism. We remind social psychological researchers that psychology was founded in multiple methods of investigation at multiple levels of analysis. We discuss historical examples and our own research as contemporary examples of how a SAGE model can operate in part or as an integrated whole. The implications of our model are discussed.
On the perceptual aesthetics of interactive objects
Authors: Soranzo Alessandro , Petrelli Daniela , Ciolfi Luigina , Reidy John
Published: January 2018

This study examined the aesthetics of interactive objects (IOs), which are three-dimensional physical artefacts that exhibit autonomous behaviour when handled. The aim of the research was threefold: first, to investigate whether aesthetic preference for distinctive objects’ structures emerges in compound stimulation; second, to explore whether there exists aesthetic preference for distinctive objects’ behaviours; and, finally, to test whether there exists aesthetic preference for specific combinations of objects’ structures and behaviours. The following variables were systematically manipulated: (a) IOs’ contour (rounded vs angular), (b) IOs’ size (small vs large), (c) IOs’ surface texture (rough vs smooth), and (d) IOs’ behaviour (lighting, sounding, vibrating, and quiescent). Results show that behaviour was the dominant factor: it influenced aesthetics more than any other characteristic; vibrating IOs were preferred over lighting and sounding IOs, supporting the importance of haptic processing in aesthetics. Results did not confirm the size and smoothness effects previously reported in vision and touch, respectively, which suggests that the aesthetic preference that emerges in isolated conditions may be different in compound stimulation. Results corroborate the smooth curvature effect. We suggest that behavior may be an aesthetic primitive.
Representation of numerical magnitude in math-anxious individuals
Authors: Colomé Àngels
Published: January 2018

Larger distance effects in high math-anxious individuals (HMA) performing comparison tasks have previously been interpreted as indicating less precise magnitude representation in this population. A recent study by Dietrich, Huber, Moeller, and Klein limited the effects of math anxiety to symbolic comparison, in which they found larger distance effects for HMA, despite equivalent size effects. However, the question of whether distance effects in symbolic comparison reflect the properties of the magnitude representation or decisional processes is currently under debate. This study was designed to further explore the relation between math anxiety and magnitude representation through three different tasks. HMA and low math-anxious individuals (LMA) performed a non-symbolic comparison, in which no group differences were found. Furthermore, we did not replicate previous findings in an Arabic digit comparison, in which HMA individuals showed equivalent distance effects to their LMA peers. Lastly, there were no group differences in a counting Stroop task. Altogether, an explanation of math anxiety differences in terms of less precise magnitude representation is not supported.
Cross-Sectional Analysis of the Distal Fibular Intramedullary Canal: A Cadaveric Evaluation
Authors: Prissel Mark A. , Daigre Justin L. , Brandão Roberto A. , Philbin Terrence M. , Hyer Christopher F. , Berlet Gregory C.
Published: January 2018

Fractures of the distal fibula secondary to rotational ankle injuries are one of the most common injuries requiring surgical intervention. The aim of this study was to describe the anatomy of the distal fibular medullary canal as a means of aiding in surgical management with an intramedullary device. Twenty fresh cadaveric below-knee specimens (group 1, 10 in 2015, group 2, 10 in 2016) were dissected to expose the distal fibular. Fifteen (10 mm each) segments were sectioned with a sagittal saw from the distal tip proximally and measured with a digital caliper. In group I, the widest and narrowest fibular diameter was at the 20-mm interval (mean 15.02 mm) and 90-mm interval (mean 3.51 mm), respectively. From 70 to 120 mm, the mean diameter was less than 4.0 mm. In group 2, the widest and narrowest diameter was at the 20-mm interval (mean 15.05 mm) and 100-mm interval (mean 4.33 mm), respectively. From 70 to 140 mm, the mean diameter was less than 5.0 mm. The combined mean diameter at the 60- to 80-mm intervals were 4.99 ± 1.70, 4.35 ± 1.63, and 4.02 ± 1.35 mm, respectively. Based on our investigation, we propose an intramedullary device diameter of 4.5 to 5.0 mm in diameter with a length of 60 to 80 mm may provide most appropriate bony purchase to achieve acceptable cortical contact for expected osseous compression.

Levels of Evidence: Level IV: Cadaveric case series
Real‐life evaluation of the safety, efficacy and therapeutic outcomes of endoscopic submucosal dissection in a Western tertiary centre
Authors: Santos-Antunes João , Baldaque-Silva Francisco , Marques Margarida , Lopes Joanne , Carneiro Fátima , Macedo Guilherme
Published: January 2018

Background

Endoscopic submucosal dissection (ESD) enables accurate pathological evaluation and low recurrence rates. Large series describing ESD outcomes in Western countries are scarce.

Objective

To evaluate the real‐life experience of ESD in a single Western centre.

Methods

Data of all the patients submitted to ESD in our centre were prospectively recorded in a database, from the first procedure in 2011 until May 2017. Feasibility, en bloc and R0 resection rates and safety were assessed.

Results

Three hundred and one ESDs were performed (37 in submucosal lesions) on 283 patients (54% male). Lesions were located in the oesophagus (n = 13), stomach (n = 169), duodenum (n = 4), colon (n = 35) and rectum (n = 80). ESD was technically successful in 292 lesions (97%); among malignant or premalignant epithelial lesions (n = 232), the en bloc resection rate was 91% and, of those, the R0 resection rate was 87% (between 69% in the colon and 93% in the stomach). Two patients needed surgery due to adverse events. Surgery for non‐curative ESD was performed in 12 cases (58% without residual lesion). There were 10 perforations, 9 of them closed endoscopically. Mortality was 0%.

Conclusion

Our real‐life experience shows that ESD is feasible, safe and effective in Western settings.
The role of imaginaries in the construction of an innovative market: A market-oriented ethnography of the nanotechnology market
Authors: Bellion Amélie , Robert-Demontrond Philippe
Published: January 2018

The aim of this article is to understand to what extent imaginaries can play a role in the construction of an innovative market. We conducted a market-oriented ethnography of the nanotechnology market construction process, analysing the strategies of three categories of stakeholders: consumers, opponents and promoters. The results reveal a new form of market construction: symbolic construction. In the case of nanotechnologies, this is based on two primary mechanisms: (1) the promotional mechanics of imaginaries, which favour the market through the simultaneous use of familiar and futuristic imaginaries; and (2) ‘meaning activism’, which challenges the market using dystopian imaginaries. This research advocates an interpretive approach to innovation, enriching the marketing literature on innovation and the social construction of markets; it also highlights certain managerial insights generated by this approach.