bluuebunny/crossref_metadata_2025 huggingface dataset:
Ganho de peso de bovinos de corte alimentados com DBR SACCH Probiótico Concentrado Pó
Authors: Factori Marco Aurélio , Corrêa Wagner , Halak Fauzi Elias , Fava Gabriel Silva
Published: April 2024

The use of probiotics as feed additives is a valuable tool for enhancing animal performance and farm efficiency. This experiment, conducted in a pasture production system with supplementation on a private property in the municipality of Rancharia, São Paulo (Brazil), aimed to evaluate the effect of DBR SACCH Probiotic Powder mixed with concentrate on weight gain, animal behavior and fecal score in beef cattle. The experiment took place from December 2023 to February 2024. Twenty-eight crossbred (Nellore X Angus) animals were used, divided into two production groups matched by weight and blood profile (weight range: 471 kg ± 3 kg), and grazing on Brachiaria brizantha cv Marandu pasture. The animals' diet consisted of free grazing and daily supplementation with 6 kg of concentrate (with an additional 2 grams of probiotic for the treatment group) for 60 days. Three weighings were conducted: at the beginning of the experiment (day 0), and at days 22 and 60 after the start of the supplementation. Animal feces scores and behavior were evaluated at each weighing. A completely randomized design was employed, with two treatments (with and without the supplement) and 14 replicates each (2 x 14). The results suggest beneficial effects from using probiotics in the animals' diet. Animals that ingested the probiotic exhibited more consistent feces and higher daily weight gains, both during the adaptation period (after 22 days of consumption) and at 60 days, with average increases of 178 and 109 grams, respectively. The use of DBR SACCH Probiotic concentrate significantly improved weight gain and fecal score in cattle, generally enhancing their overall performance in the field. This improvement is attributed to the use of the product in conjunction with concentrate and pasture feeding.
Sosyalleşmeye Engel Bir Araç Olarak Televizyon
Authors: Tatar Mustafa
Published: April 2024

Televizyonun hayatımıza girmesinden bu yana uzun yıllar geçti. Televizyonlu bir dünyaya doğanlar bilmeseler de televizyon öncesi çağlarda sokaklar cıvıl cıvıldı. Çocuklar sakağa çıkar hiç sıkılmadan saatlerce oyun oynarlar ve zamanlarının önemli bir kısmını sokakta geçirirlerdi. Komşular birbirlerini sık sık ziyaret ederlerdi. Birisi konuşurken herkes gözünün içine bakar başka bir şeyle meşgul olmak ayıp karşılanırdı. Televizyonla birlikte tüm alışkanlıklarımız değişti. Önce çocuklar evlerine çekildiler daha sonra yetişkinler. Çocuk seslerinin kaybolduğu sokaklar tenhalaştı. Komşular birbirlerini ziyaret etmez oldular. Ziyaret etseler bile muhabbetin tadı kalmadı. Çünkü insanlar bir araya geldiklerinde birbirleriyle konuşmak yerine sürekli açık olan televizyonla meşgul olmayı tercih ettiler. İnsanların gözlerinin televizyonda olduğu bir ortamda konuşan kişi de konuştuklarından keyif alamaz oldu. Fakat televizyonun yaygınlaşması en çok çocuklara zarar verdi. Çocuklar çeşitli oyunlar oynamak, kendi aralarında ve büyüklerle konuşmak yerine televizyonun karşısına geçip saatlerini harcadılar. Yetişkinler, çocukların zamanlarının önemli bir bölümünü televizyon karşısında geçirdikleri bu yeni duruma itiraz etmediler. Çünkü zamanlarını istedikleri gibi kullanabilecekleri bir alan doğmuştu. Fakat çocuklar televizyon izledikçe gerçek yaşamdan kopup sanal dünyanın içinde kayboldular. Belki çoğu kimse farkında değil ama televizyonun karşısında geçirilen süre onların insan olmayı öğrenmek için ihtiyaçları olan süreden çalınmaktadır. Bu makalede televizyonun insan olmayı öğrenme süreci olarak tanımlanabilecek olan sosyalleşmenin önünde nasıl bir engel teşkil ettiği üzerinde durulmaktadır.
Борис Буєвський: творчий портрет на тлі музичних процесів другої половини XX століття
Authors: Верещагіна-Білявська Олена , Степова Алла
Published: April 2024

The article is devoted to highlighting the peculiarities of the period of formation of the musical avant-garde in Ukraine in the 60s-80s of the twentieth century. This period was a time of oppression, misunder­standing, bans and repressions of all Ukrainian art by the Soviet au­thorities, and, on the other hand, years of bold compositional searches and the formation of a new musical thinking oriented towards the mu­sical culture of Western Europe, bypassing the established rules and censorship. This period became a new historical milestone in the de­velopment of Ukrainian music, marked by the emergence of names of composers of a different formation and outlook. First of all, this directly concerns the group of composers «Kyiv Avant-Garde», who formed new traditions and laid the foundation for the further development of Ukrainian musical art.
Among the well-known composers of that time, a significant place be­longed to the nonconformist composer Borys Buievskyi. The artist's desire to preserve his individuality in spite of the totalitarian, ideologi­cal dogmas of the authorities, to manifest his national essence and consciousness was reflected in his work, which is distinguished by the courage of ideas, relevance of themes and rebellious sound. The arti­cle traces its affiliation with both innovative musical findings and trends of the time and the appeal to the heritage of the past musical culture, its previous achievements, which were embodied in the tech­nique of polystylistics, which became a defining feature of the compos­er's work.
The article describes the genre palette, peculiarities of the musical language and forms of his works. The music of the early period of Borys Buievskyi's work is analyzed, which is represented primarily in the works of the vocal genre, namely pop songs. On the example of the ballets «Song of the Blue Sea», «Ustym Karmeliuk», music for ani­mated films and symphonic works, the evolution of the composer's technique and consciousness of the artist, which moved towards deep­ening the themes, bold sound and stylistic combinations, is traced.
Роль духовної музики у творчості українських композиторів
Authors: Грінченко Тетяна , Клітинська Ольга
Published: April 2024

The article is devoted to consideration of the role of spiritual music in the work of Ukrainian composers and its influence on the development of mu­sical culture in Ukraine. The essence of the concept of «sacred music» is revealed, various approaches of modern scientists to its definition are highlighted.
The purpose of the article is to consider the role of spiritual music in the work of Ukrainian composers and its influence on the development of mu­sical culture in Ukraine.
There are several approaches to understanding the meaning of the con­cept of «sacred music»: is considered church music and is a mandatory part of Orthodox worship; as a means of cognition, a certain type of social and informational system that fulfills the polyfunctional nature of inter­subjective interaction that forms the «artistic environment» of this sys­tem, as well as the personal qualities of a person that encourage him to know and develop his creative potential, giving priority to universal and artistic values. Despite different positions regarding the definition of the concept of «sacred music», researchers saw in it a significant potential for the education of the individual and his values. Turning to spiritual mu­sic, which is an asset and part of the people's culture, is necessary for the preservation of national traditions of moral and aesthetic education.
Spiritual works influence the for­mation of national identity, encourage reflection on important life issues, and give depth and meaning to the musical world. The creativity of Ukrainian composers dedicated to spiritual music is a priceless treasure that must be supported and promoted both within Ukraine and beyond. It deserves proper recognition and dissemination to inspire and strengthen the spirituality of people around the world.
Педагогічні ідеї Віталія Івановича Газінського у контексті професійної підготовки здобувачів музично-педагогічної освіти
Authors: Сідорова Ірина , Грінченко Тетяна , Василевська-Скупа Людмила
Published: April 2024

The article summarizes the pedagogical ideas and stylistic features of the teaching activity of the outstanding representative of the Odesa Choir School, Professor Vitaly Ivanovych Gazinsky, in the context of training future music teachers and teachers of art disciplines for professional activity. Peculiarities of the artist's personal, professional, compositional, creative, performing qualities in achieving pedagogical achievements, high skill, gaining fame and recognition in a wide range of cultural environments of our country and abroad are noted. The historical significance of Vitaly Gazinskyi's multi-spectral activity in the development of the Podil choral school and national choral art in general is emphasized. On the example of the analysis of music-pedagogical, scientific and creative-performance activity of the conductor, the question of formation of personal and professional qualities of future music teachers is considered.
The theoretical and practical aspects of the choirmaster's pedagogical activity, the formation of his humanitarian worldview and professional competences, outlined in the scientific and methodological works of Professor Vitaly Gazinskyi, are highlighted. The provisions of the educational and methodological manual "Educational Choir" regarding the use of the synthesis of scientific and creative activities in the system of musical and pedagogical education are substantiated. The content of the mentioned work is analyzed, which reveals the methodological foundations of the formation of professional skills and personal skills of future music teachers and teachers of artistic disciplines, in particular in the role of leaders of children's, youth creative teams, professional choirs. Emphasis is placed on the development of the artistic and aesthetic component of students' personality in the organization of the educational process using a wide range of disciplines of general training, as well as music-theoretical and vocal-choral disciplines.
It is noted that the pedagogical, creative-performing, conducting and choral achievements of the great artist V. Gazinsky deserve the attention of teachers, choirmasters, musicologists and other circles of scientists.
The lateral retrocanthal transorbital endoscopic approach to the middle fossa: cadaveric stepwise approach and review of quantitative cadaveric data
Authors: Komaitis Spyridon , Skandalakis Georgios P. , Drosos Evangelos , Neromyliotis Eleftherios , Charalampopoulou Eirini , Anastasopoulos Lykourgos , Zenonos Georgios , Stranjalis George , Kalyvas Aristotelis , Koutsarnakis Christos
Published: April 2024

OBJECTIVE

The lateral retrocanthal transorbital endoscopic approach (LRCTEA) facilitates trajectory to the middle fossa, preserving the lateral canthal tendon and thus avoiding postoperative complications such as eyelid malposition. Here, the authors sought to define the surgical anatomy and technique of LRCTEA using a stepwise approach in cadaveric heads and offer an in-depth examination of existing quantitative data from cadaveric studies.

METHODS

The authors performed LRCTEA to the middle cranial fossa under neuronavigation in 7 cadaveric head specimens that underwent high-resolution (1-mm) CT scans preceding the dissections.

RESULTS

The LRCTEA provided access to middle fossa regions including the cavernous sinus, Meckel’s cave, and medial temporal lobe. The trajectories and endpoints of the approach were confirmed using electromagnetic neuronavigation. A stepwise approach was delineated and recorded.

CONCLUSIONS

The authors’ cadaveric study delineates the surgical anatomy and technique of the LRCTEA, providing a stepwise approach for its implementation. As these approaches continue to evolve, their development and refinement will play an important role in expanding the surgical options available to neurosurgeons, ultimately improving outcomes for patients with complex skull base pathologies. The LRCTEA presents a promising advancement in skull base surgery, particularly for accessing challenging middle fossa regions. However, surgeons must remain vigilant to potential complications, including transient diplopia, orbital hematoma, or damage to the optic apparatus.
Transpalpebral mini-orbitozygomatic approach for nonvascular skull base lesions: a single neurosurgeon’s experience
Authors: Tavakoli Samon , Armstrong Stephanie A. , Feller Christina , Hong Sang Hun , Zwagerman Nathan T.
Published: April 2024

OBJECTIVE

The authors aim to describe the advantages, utility, and disadvantages of the transpalpebral mini-orbitozygomatic (MOZ) approach for tumors of the lateral and superior orbit, orbital apex, anterior clinoid, anterior cranial fossa, middle cranial fossa, and parasellar region.

METHODS

The surgical approach from skin incision to closure is described while highlighting key technical and anatomical considerations, and cadaveric dissection demonstrates the surgical steps and focuses on important anatomy. Intraoperative images were included to supplement the cadaveric dissection. A retrospective review of adults who had undergone the MOZ approach for nonvascular pathology performed by a single neurosurgeon from 2017 to 2023 was included in this institutional review board–approved study. Descriptive statistics was used to summarize the data. Four representative cases were included to demonstrate the utility of the MOZ approach.

RESULTS

The study included 65 patients (46 female, 19 male), average age 54.84 years, who had undergone transpalpebral MOZ surgery. Presenting symptoms included visual changes (53.8% of cases), vision loss (23.1%), diplopia (21.8%), and proptosis (13.8%). The optic nerve and optic chiasm were involved in 32.3% and 10.8% of cases, respectively. The most common pathology was meningioma (81.5% of cases), and gross-total resection was achieved in 50% of all cases. Major complications included an infection and a carotid injury. Improvement of preoperative symptoms was reported in 92.2% of cases. Visual acuity improved in 12 patients. The mean follow-up was 8.57 ± 8.45 months.

CONCLUSIONS

The MOZ approach is safe and durable. The transpalpebral incision provides better cosmesis and functional outcomes than those of standard anterolateral approaches to the skull base. Careful consideration of the limits of the approach is paramount to appropriate application on a case-by-case basis. Further quantitative anatomical studies can help to define and compare the utility of the approach to open cranio-orbital and endoscopic transorbital approaches.
Endoscopy for T10 nerve sheath tumor
Authors: Dhandapani Sivashanmugam , Gendle Chandrashekhar
Published: April 2024

Minimally invasive surgery (MIS) is increasingly being adopted for spinal intradural tumors. Through the use of conventional microscopy or exoscopy for large lobulated nerve sheath tumors, the posterior root attachment is often visualized only after mobilizing the tumor. Here, the authors describe the utility of angled endoscopy with its panoramic view for a T10 nerve sheath tumor. Gross-total extracapsular excision was achieved utilizing a minimally invasive right paraspinous approach, fenestration, lateral durotomy, sliding delivery of the tumor, sharp dissection of radicular attachments under neuromonitoring, and dural closure with oblique clips. Angled endoscopes help visualize the attachments behind large multilobulated tumors and confirm the totality of excision.

The video can be found here: https://stream.cadmore.media/r10.3171/2024.1.FOCVID23214
Biportal endoscopic posterior cervical foraminotomy with discectomy for unilateral radicular arm pain due to cervical herniated disc
Authors: Heo Dong Hwa
Published: April 2024

Recently, biportal endoscopic cervical approaches have been used to treat cervical degenerative disease. Biportal endoscopic posterior cervical foraminotomy with or without discectomy has the advantage of reducing damage to the normal tissues during surgery and enhancing fast recovery after surgery. The biportal endoscopic cervical approach was performed using two portals. The first portal was an endoscopic viewing portal for the spinal endoscope, and the other portal was a working portal for using surgical instruments. The author illustrates the surgical technique of biportal endoscopic posterior cervical foraminotomy with discectomy.

The video can be found here: https://stream.cadmore.media/r10.3171/2024.1.FOCVID23225
Surgical management of tethered spinal cord syndrome through biportal endoscopic approach: a novel technical note
Authors: Özer Mehmet İlker , Ezgü Mehmet Can , Kaplan Ali , Çulcu Gürcan Zeliha , Demirtaş Oğuz Kağan
Published: April 2024

This video article explores a case of tethered cord release through a minimally invasive biportal endoscopic approach. A 24-year-old female with chronic back pain and thigh numbness underwent surgery. The chosen approach involved biportal endoscopic technique, demonstrating precision with minimal bone excision. Preoperative imaging revealed a midline fusion defect at L5 and abnormal conus medullaris termination. The surgical procedure involved one-sided hemilaminectomy, durotomy, and careful filum terminale separation. Postoperatively, radiological exams confirmed success with minimal bone defect. Emphasizing minimal invasiveness, reduced bone excision, and muscle sparing, this technique showcased successful outcomes, enabling the patient’s rapid postoperative recovery without complications.

The video can be found here: https://stream.cadmore.media/r10.3171/2024.1.FOCVID23228
Anterolateral keyhole transorbital routes to the skull base: a comparative anatomical study
Authors: Karampouga Maria , Terrarosa Anna K. , Patel Bhuvic , Affolter Kyle , Wang Eric W. , Choby Garret W. , Fu Roxana , Bonhomme Gabrielle R. , Stefko S. Tonya , McDowell Michael M. , Snyderman Carl H. , Gardner Paul A. , Zenonos Georgios A.
Published: April 2024

OBJECTIVE

Although keyhole transorbital approaches are gaining traction, their indications have not been adequately studied comparatively. In this study the authors have defined them also as transwing approaches—meaning that they use the different facies of the sphenoid wing for cranial entry—and sought to compare the four major ones: 1) lateral orbitocraniotomy through a lateral canthal incision (LatOrb); 2) modified orbitozygomatic approach through a palpebral incision (ModOzPalp); 3) modified orbitozygomatic approach through an eyebrow incision (ModOzEyB); and 4) supraorbital craniotomy through an eyebrow incision (SupraOrb), coupled with its expanded version (SupraTransOrb).

METHODS

Cadaveric dissections were performed at the neuroanatomy lab. To delineate the skull base exposure, four formalin-fixed heads were used, with two sides dedicated to each approach. The outer limits were assessed via image guidance and were mapped and illustrated accordingly. A fifth head was dissected purely endoscopically, just to facilitate an overview of the transwing concept. Qualitative features were also rigorously examined.

RESULTS

The LatOrb proves to be more versatile in the middle cranial fossa (MCF), whereas the anterior cranial fossa (ACF) exposure is limited to a small area above the sphenoid ridge. An anterior clinoidectomy is possible; however, the exposure of the roof of the optic canal is suboptimal. The ModOzPalp adequately exposes both the ACF and MCF. Its lateral trajectory allows the inferior to superior view, yet there is restricted access to the medial anterior skull base (olfactory groove). The ModOzEyB also provides extensive exposure of the ACF and MCF, but has a more superior to inferior trajectory compared to the ModOzPalp, making it more appropriate for pathology reaching the medial anterior skull base or even the contralateral side. The anterior clinoidectomy is performed with improved visualization of the optic canal. The SupraOrb provides mainly anterior cranial base exposure, with minimal middle fossa. An anterior clinoidectomy can be performed, but without any direct observation of the superior orbital fissure. Some MCF access can be accomplished if the lateral sphenoid wing is drilled inferiorly, leading to its highly versatile variant, the SupraTransOrb.

CONCLUSIONS

All the aforementioned approaches use the sphenoid wing as skull base corridor from a specific orientation point; hence these are designated as transwing approaches. Their peculiarities mandate careful case selection for the effective and safe completion of the surgical goals.
Isolated unilateral alar ligamentous injury: illustrative cases
Authors: Reeves Benjamin C , Valcarce-Aspegren Marcus , Robert Stephanie M , Elsamadicy Aladine A , Tucker Alexander M , Storm Phillip B , DiLuna Michael L , Kundishora Adam J
Published: April 2024

BACKGROUND

Isolated unilateral alar ligament injury (IUALI) is a rare and likely underreported occurrence after upper cervical trauma, with only 16 cases documented in the literature to date. Patients generally present with neck pain, and definitive diagnosis is typically made by magnetic resonance imaging (MRI). Unfortunately, likely due in part to its rarity, there are no formal guidelines for the treatment of an IUALI. Furthermore, there is a limited understanding of the long-term consequences associated with its inadequate treatment.

OBSERVATIONS

Here, the authors report on three pediatric patients, each found to have an IUALI after significant trauma. All patients presented with neck tenderness, and two of the three had associated pain-limited range of neck motion. Imaging revealed either a laterally deviated odontoid process on cervical radiographs and/or MRI evidence of ligamentous strain or discontinuity. Each patient was placed in a hard cervical collar for 1 to 2 months with excellent resolution of symptoms. A comprehensive review of the literature showed that all patients with IUALI who had undergone external immobilization with either rigid cervical collar or halo fixation had favorable outcomes at follow-up.

LESSONS

For patients with IUALI, a moderate course of nonsurgical management with rigid external immobilization appears to be an adequate first-line treatment.
Quantitative susceptibility mapping and a nonlinearly transformed atlas for targeting the ventral intermediate nucleus of the thalamus in a patient with tremor and thalamic hypertrophy: illustrative case
Authors: Ohtsuki Kazuya , Sawada Masahiro , Yoshizaki Wataru , Ishimori Takayoshi , Sawamoto Nobukatsu , Fushimi Yasutaka , Toda Hiroki
Published: April 2024

BACKGROUND

The ventral intermediate nucleus (Vim) of the thalamus is a surgical target for treating various types of tremor. Because it is difficult to visualize the Vim using standard magnetic resonance imaging, the structure is usually targeted based on the anterior and posterior commissures. This standard targeting method is practical in most patients but not in those with thalamic asymmetry. The authors examined the usefulness of quantitative susceptibility mapping (QSM) and transformed Vim atlas images to estimate the Vim localization in a patient with tremor and significant thalamic hypertrophy.

OBSERVATIONS

A 51-year-old right-handed female had experienced a predominant left-hand action tremor for 6 years. Magnetic resonance imaging showed significant hypertrophy of the right thalamus and caudal shift of the thalamic ventral border. The authors referred to the QSM images to localize the decreased susceptibility area within the lateral ventral thalamic nuclei to target the Vim. In addition, the nonlinearly transformed Vim atlas images complemented the imaging-based targeting. The radiofrequency thalamotomy at the modified Vim target relieved the tremor completely.

LESSONS

A combination of QSM and nonlinear transformation of the thalamic atlas can be helpful in the targeting method of the Vim for tremor patients with thalamic asymmetry.
РЕЗУЛЬТАТИ ЛАБОРАТОРНИХ ДОСЛІДЖЕНЬ ДВОЯРУСНОГО ФРОНТАЛЬНОГО ВОДОЗАБОРУ
Authors: Вечер В. В. , Шинкарук Л. А. , Токар Л. О.
Published: April 2024

В роботі розглянуто результати досліджень структури потоку та протинаносних властивостей фронтального двоярусного водозабору, влаштованого на передгірській ділянці річки. В лабораторних умовах досліджено процес переносу наносів в руслі на підході до водоприймачів водозабору та їх захват у канали для різних режимів роботи.
Congenital Heart Disease among Children Undergoing Echocardiography in the Department of Paediatrics of Tertiary Care Centre: A Descriptive Cross-sectional Study
Authors: Chimoriya Romila , Chimoriya Ritesh Chimoriya , Shrestha Mandira , Shrestha Sabina , Shah Kailash , Lama Lopsang , Rana Kritika
Published: April 2024

Introduction: Congenital heart disease in children are a major cause of infant mortality and morbidity. It is important to detect and manage these disorders timely as they are preventable. The objective of this study was to find out proportion of congenital heart disease in children in paediatric department in a tertiary hospital.Methods: This is a descriptive cross-sectional study carried out in the Department of Paediatric at Nepal Medical College and Teaching Hospital where all children (0-18 years) suspected to have congenital heart disease who underwent echocardiography were studied over a period of 1 year (2020-2021). The presence or absence of congenital heart disease were confirmed by echocardiography performed by paediatric cardiologist. The socioeconomic variables,clinical features and echocardiography findings were noted.Results: Out of total 249 patients,the proportion of patients diagnosed to have cardiac disorders was 73 with male predominance of 165 (66.26%). The most common age group was found to be neonates 111 (44%).The notable clinical features were murmur 47 (18.87%), tachypnoea 27 (10.84%) ,tachycardia 27 (10.84%) and cyanosis 9 (3.61%), clubbing 2 (0.80%), oedema 1 (0.40%), hypertension 9 (3.65%), murmur 47 (18.87%).Out of the total, there were 49 (19.67%) cases of acyanotic congenital heart disease, and 27 (10.84%) cases of cyanotic congenital heart disease.Conclusions: Our study focuses on early recognition of cardiac diseases which is crucial for preventing morbidity and mortality.
Implementation Of Protocol Services In Supporting The Activities Of The Enrekang Regent
Authors: Briutli Slamet , Nurlinah Nurlinah , Kurniaty Kurniaty
Published: April 2024

The purpose of this study was to find out the efforts of the Enrekang Regency government in maximizing protocol aspects to succeed in every activity and an official event of the 2022 Enrekang Regent. The research method is to use a mixed methods approach. The research population is the recipients of protocol services. The research sample found as many as 78 respondents. The research results show that resources, mandates, and protocol functions are crucial aspects in the implementation of protocol services in supporting the activities of the Regent of Enrekang. Nonetheless, this study found the assessment results on the implementation identified as less than optimal. There are several influential aspects, including human resources issues, communication, and management of protocol activities. This tendency requires accommodative action, namely performance evaluation by the protocol leadership. Evaluation can be done to anticipate and minimize the same errors that may occur in the future. This is also necessary to continue to support every activity of the Regent of Enrekang.
Model Strategi Agenda Penanganan Kekerasan Seksual Melalui Media Konvergen
Authors: Adventy Maria Immaculata Yovita , Putra Raniasa
Published: April 2024

Abstrak : Maraknya media konvergen, termasuk media sosial, memudahkan mengakses informasi tentang kekerasan seksual, baik korban maupun pelakunya, baik yang dilakukan oleh saudara maupun orang yang tidak dikenal. Tinjauan literatur ini bertujuan untuk mengidentifikasi temuan positif dan negatif terkait kekerasan seksual. Metode penelitian yang digunakan adalah deskriptif kualitatif, dengan menggunakan teori Michael Howlet dan M. Ramesh 1995 dalam penetapan agenda pemerintah. Hasilnya menunjukkan pentingnya memasukkan kekerasan seksual sebagai agenda utama pemerintah, dengan menghasilkan dua inovasi model strategi yaitu Inovasi Model Strategis: Kebijakan mendorong percepatan agenda setting dan model inovasi pada aplikasi pelayanan korban kekerasan seksual.Abstract:  The rise of convergent media, including social media, facilitates access to information about sexual violence, both victims and perpetrators, whether committed by relatives or strangers. This literature review aims to identify positive and negative findings related to sexual violence. The research method used was descriptive qualitative, using Michael Howlet and M. Ramesh's 1995 theory on government agenda setting. The results show the importance of including sexual violence as a major government agenda, by producing two strategic model innovations, namely Strategic Model Innovation: Policies to accelerate agenda setting and model innovation in the application of services for victims of sexual violence.
УБЕЗПЕЧЕННЯ ДІЯЛЬНОСТІ ПІДПРИЄМСТВА ЯК ОБ’ЄКТ УПРАВЛІННЯ
Authors: ЛУТЮК Василь , ГАВЛОВСЬКА Наталія
Published: April 2024

Розширення меж забезпечення економічної безпеки підприємства зумовило необхідність більш широкого погляду на цей процес у вигляді убезпечення діяльності підприємства. Зміст поняття «убезпечення діяльності підприємства» розглянуто з позицій об’єктно-суб’єктного підходу як сукупність взаємопов’язаних та взаємозумовлених у просторі та часі ресурсно забезпечених безпекозабезпечувальних дій, результатом яких є безпечний стан об’єктів безпеки підприємства, між якими існують щільні зв’язки, відносини та взаємовплив.

Убезпечення діяльності підприємства як новий вид його діяльності має бути об’єктом управління. Об’єктність управління в економічній безпекології стосовно практично всіх об’єктів економічної безпеки належать до питань, які не отримали повного вирішення. Тому це питання вирішено шляхом адаптації загальних положень теорії управління до управління убезпеченням діяльності підприємства з урахуванням специфіки та особливостей цього нового виду діяльності підприємства.

Визначено, що до управління будь-яким об’єктом або процесом застосовуються кілька підходів. Найпоширенішим є функціональний підхід, і ми не бачимо необхідності відмовлятися від нього в управлінні убезпеченням діяльності підприємства. Застосування функціонального підходу надає можливість сформувати однорідні окремі блоки робіт та операцій з управління убезпеченням діяльності підприємства тобто його функції.

Управління убезпеченням діяльності підприємства розглянуто з позиції функціонального підходу, що надало змогу сформувати сукупність функцій управління, які відображають специфіку управління цим видом діяльності. Обсяг функцій управління убезпеченням діяльності підприємства, головним виконавцем яких є структурний підрозділ з безпеки, залежить від його компетенцій.
ТЕОРЕТИЧНІ ОСНОВИ ЛОГІСТИЧНОЇ ДІЯЛЬНОСТІ ПІДПРИЄМСТВ
Authors: ЛІСОВСЬКИЙ Ігор , ШЕРШЕЛЮК Дмитро , ЧУК Володимир , МАРТИНЮК Олексій
Published: April 2024

Логістика у більшості праць історичного характеру досліджується з позиції забезпечення військової діяльності різних років та епох, так для древніх греків логістика становила «логістичне мистецтво» або «мистецтво міркування, обчислення». Логістика розвивалася у різних напрямах, а саме: у промисловості, військових операціях, транспортуванні, інформаційних технологіях. У статті розглянуто сутність поняття «логістика» та «логістична діяльність» і наведено авторські визначення понять. На нашу думку, під логістикою слід розуміти комплексну систему планування, координації та контролю різних процесів, пов'язаних з управлінням потоками матеріальних ресурсів, товарів, послуг та інформації від постачання до кінцевого споживача. При цьому основною метою логістики є забезпечення оптимальної та ефективної роботи ланцюга постачання для задоволення потреб споживачів і максимізації прибутковості бізнес-процесів суб’єктів господарювання. Під «логістичною діяльністю» слід розуміти комплекс рішень, заходів та процесів, що спрямовані на організацію та оптимізацію матеріальних, інформаційних та фінансових потоків з метою досягнення цілей підприємства та задоволення запитів споживачів. Логістичне забезпечення є запорукою логістичної діяльності, і включає весь комплекс операцій та заходів, що забезпечують функціонування логістичної системи організації, зокрема: постачання / закупівлю, управління запасами, виробництво, складування, транспортування та збут. Логістичне забезпечення дозволяє менеджменту підприємств формувати необхідні логістичні потоки. Вони дозволяють гнучко реагувати на запити ринку та реалізовувати на відповідному рівніопераційні процеси. Це значно підвищує якість операційного менеджменту. Логістичне забезпечення реалізується за рахунок ефективного управління матеріальними та інформаційними потоками, і передбачає їх оптимізацію з метою мінімізації затрат, забезпечення якості та дотримання встановлених термінів.
Impact of IDH Mutations on DNA Methylation of Acute Myeloid Leukemia Related Genes: A Review Article
Authors: M. Bayram Duha , M. Lafta Fadhel , F. Matti Bassam
Published: April 2024

الخلفية العلمية: ابيضاض الدم النخاعي الحاد (AML) هو أحد أكثر الأورام الدموية الخبيثة فتكًا و تتميز بوظائف خلوية غير طبيعية وتغيرات جينية. و تبين ان الطفرات في جينات نازعة هيدروجين إيزوسيترات (IDH) وخاصة IDH1 و IDH2 ، على أنها تشوهات وراثية متكررة في مرضى ابيضاض الدم النخاعي الحاد .و تؤدي هذه الطفرات إلى نشاط إنزيمي غير طبيعي، مما يؤدي إلى تراكم 2-هيدروكسي جلوتارات  (2-HG)،,والذي بدوره يعطل العمليات الخلوية الطبيعية بما في ذلك مثيلة الحمض النووي.
الهدف: تهدف مقالة المراجعة هذه إلى استعراض الطفرات الجينية المسجلة لـ, IDH   التحقق من العلاقة بين تلك الطفرات والتغييرات في أنماط مثيلة الحمض النووي، وآثارها على التسبب في الإصابة بابيضاض الدم النخاعي الحاد والتنبؤ به وعلاجه.
المواد وطرق العمل: تم إجراء بحث شامل في الأدبيات العلمية لتحديد الدراسات ذات الصلة التي تبحث في تأثير طفرات IDH على الجينات المرتبطة بمثيل الحمض النووي في المرضى الذين يعانون من ابيضاض الدم.  وتمت مراجعة الدراسات المختارة وتحليلها لغرض الوصول الى المعلومات والمعرفة الحالية حول هذا الموضوع.
النتائج: سلطت هذه المقالة الضوء على أن طفرات IDH في AML مرتبطة بتغيرات واسعة النطاق في أنماط مثيلة الحمض النووي. تؤثر هذه التغييرات في المقام الأول على الجينات المرتبطة بإضافة مجموعة المثيل الى الحمض النووي، بما في ذلك DNA methyltransferases (DNMTs)  وبروتيناتTET.  بالتالي يؤدي خلل تنظيم مثيلة الحمض النووي إلى فرط مثيل الحمض النووي بصورة عامة بالإضافة الى جينات محددة بصورة خاصة، ووكون علامة المثيل الطبيعية تسهم في تنظيم التعبير الجيني، فأن هذا الاضطراب الجزيئي يساهم في اختلال الوظائف الخلوية الطبيعية ونشوء مرض AML.
الخلاصة: تدعم نتائج مقالة المراجعة هذه التأثير المهم لطفرات جين IDH على الجينات المرتبطة بمثيلة الحمض النووي في AML. و يوفر فهم التفاعل بين طفرات IDH وخلل تنظيم مثيلة الحمض النووي نظرة استكشافية لمسببات AML  والتنبؤ بتطوره ومجالا واعدا لتطوير العلاجات الاستهدافية ز.
 
الكلمات المفتاحية: AML ، نازعة هيدروجين الأيزوسيترات ، IDH ، مثيلة الحمض النووي DNA methylation ، DNA methyltransferases ، بروتينات TET ، العلاج الموجه.
On the Necessity of Prevalence Studies on Circumscribed Choroidal Hemangioma in Iraq
Authors: Al-Imam Ahmed M. , Al-Zahawi Farah A. , Sahai Ashok
Published: April 2024

Background: Circumscribed choroidal hemangioma (CCH), a rare benign tumor, poses significant risks to vision due to its proximity to the macula, with epidemiology varying from one population to another.Objectives: The present article emphasizes the need for prevalence studies on CCH in Iraq.Methods: In June 2023, a literature review was conducted on PubMed, followed by a secondary analysis of patients' demographic data from diverse populations and ethnic groups worldwide.Results: The secondary literature analysis revealed demographic variations in CCH, including age and gender (male-to-female) ratios, and across different populations. The exact prevalence remains unclear, particularly in Iraq, due to limited data and asymptomatic cases. Accurate diagnosis through imaging techniques is crucial for symptomatic cases, with treatment modalities like PDT available. Economic challenges persist in Iraq, highlighting the need for collaboration between healthcare and government sectors. Conclusion: The lack of CCH prevalence studies in Iraq impedes understanding and management, impacting ophthalmology care for Iraqi patients. Addressing this gap through research can benefit local healthcare authorities and provide essential data for the Middle East and other regions worldwide
ВПЛИВ N-АЦЕТИЛЦИСТЕЇНУ ТА ЛОЗАРТАНУ НА МОДУЛЮВАННЯ ЦИТОПРОТЕКТОРНОЇ АУТОФАГІЇ В МІОКАРДІ ЩУРІВ ПРИ ЕКСПЕРИМЕНТАЛЬНОМУ ЦУКРОВОМУ ДІАБЕТІ 1 ТИПУ (ЗА ДАНИМИ ЕЛЕКТРОННОЇ МІКРОСКОПІЇ)
Authors: Sytnyk I.M. , Stechenko L.O. , Krivosheeva O.l. , Натрус Л.В. , Khaitovych M.V.
Published: April 2024

Мета роботи. Вивчити особливості аутофагїї за стрептозотоцин-індукованого ЦД 1 типу та її зміни при застосуванні різних фармакологічних схем N-ацетилцистеїну та лозартану.
Матеріали та методи. Цукровий діабет 1 типу (ЦД1) моделювали введенням щурам стрептозотоцину (STZ) у дозі 50 мг/кг. Дослідні тварини були розподілені на 5 груп: контроль (група інтактних щурів); ЦД1 (група модельних тварин із STZ ЦД1, які отримували 0,9% фізіологічний розчин); NAC (група діабетичних щурів, які отримували N-ацетилцистеїн у дозі 1,5 г/кг per os); LOS (група діабетичних щурів, які отримували лозартан у дозі 20 мг/кг per os); NAC+LOS (група діабетичних тварин, які отримували комбінацію N-аце- тилцистеїну та лозартану). Матеріалом для електронномікроскопічних досліджень були ділянки міокарду лівого шлуночка серця.
Результати. В кардіоміоцитах щурів із STZ ЦД1 встановлено структурні зміни метаболічного характеру (зміни у мітохондріях ендоплазматичній сітці, лізосомах та аутофагосомах). У дослідній групі NAC встановлено ультраструктурні ознаки активації білоксинтетичних процесів в кардіоміоцитах направлених на новоутворення міофібрил на тлі гіпертрофії органел метаболічного плану; активувалися процеси аутофагїї У групі LOS на ряду зі зменшенням кількості аутофагосом відмічалися більш суттєві ушкодження у енергетичному та скоротливому апараті кардіоміоцитів: деструкція мітохондрій, перескорочення міофібрил та їх локальний лізис, білкова дистрофія, локальний парцеальний некроз цитоплазми кардіоміцитів. У групі NAC+LOS також значно зменшувалаясь кількість аутофагосом і відмічались дистрофічні зміни в кардіоміоцитах та порушення гемомікроциркуляторного русла.
Висновки. За даними електронномікроскопічного дослідження, NAC виявив більшу ефективність у відновленні аутофаготичної цитопротекторної системи, що пояснюється його модулюючим впливом на мішень оксидативний стрес-аутофагія, що може стати новою терапевтичною стратегією у пошуку селективних кардіопротекторних лікарських засобів для пацієнтів із діабетичною кардіоміопатією.
ЗВ’ЯЗОК АФЕКТИВНИХ ТА ІНШИХ ПСИХІЧНИХ РОЗЛАДІВ ІЗ ТВОРЧОЮ ДІЯЛЬНІСТЮ, ЇХ ДЕЯКІ НЕЙРОХІМІЧНІ МЕХАНІЗМИ
Authors: Bedlinskyi V.O.
Published: April 2024

Публікація присвячена пошуку взаємозв'язку афективних та інших психічних розладів із творчістю індивіда. Проаналізовано історичні та сучасні погляди на цю проблему, розглянуті сучасні дані про нейрохімічні механізми, котрі відіграють ключову роль, як у процесі творчості, так і у розвитку психічних захворювань. Висвітлена роль допамінергічної нейротрансмісії як одного з основних біохімічних механізмів забезпечення творчої діяльності. Зроблено висновок про те, що вивчення та врахування зв'язку психічних розладів і творчої діяльності, в тому числі ролі та особливостей функціонування нейротрансмітерних систем може слугувати засобом удосконалення лікувально-діагностичної, профілактичної та реабілітаційної допомоги даній категорії душевнохворих.
EFFECT OF DOUBLE HYPOGLYCEMIC THERAPY WITH METFORMIN AND SAXAGLIPTIN, ON ACHIEVEMENT OF GLYCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES AND ADJUVANT OBESITY
Authors: Nikulina Liliia
Published: April 2024

The main goals of the current research on the management of patients with type 2 diabetes are the assessment of the effects of early intensive glycemic control on the development and progression of the disease and its complications and the discovery of the clinical benefits of various types of hypoglycemia. Given the convincing evidence of beneficial effects on the course of the disease, inhibitors of dipeptidyl peptidase-4, primarily saxagliptin, should be considered as a group of first-line hypoglycemic therapy, along with metformin, in the treatment of patients with high-risk type 2 diabetes with concomitant diseases. In a study involving 31 patients with type 2 diabetes, obesity and inadequate glycemic control, on the background of recommended monotherapy metformin, the effectiveness of combination therapy with saxagliptin and metformin was demonstrated. The comparison group consisted of 29 patients with monotherapy metformin at a dose of 2000 mg per day. In most patients receiving saxagliptin at a dose of 5 mg in combination with metformin, a decrease in HbA1c, glucose uptake and postprandial glycaemia was observed compared to baseline values. These results were also more significant compared to the metformin monotherapy group. In addition, the appointment of combination therapy contributed to the improvement of functional activity of  - cells of the pancreas. The obtained results allow us to recommend this scheme of combination therapy for the management of patients with type 2 diabetes with obesity.
Do First-Mover Advantages Really Matter for Internet Ventures in Emerging Markets? A Study of Localization and Platform Envelopment Capabilities on New Venture Growth
Authors: Santoso Adhi Setyo
Published: April 2024

In the past decades, first mover advantages have been discussed widely as one of the critical success factors of venture performance. However, recent phenomena in emerging markets such as Indonesia show that late entrants in the Internet venture sector have better performance compared to the pioneers. The late entrants' Internet ventures start with not only a single service, but also multi-bundled complementary services. Therefore, the platform envelopment phenomenon, an entry path effort that utilizes existing competitor platform network effects, is happening. The platform envelopment, as well as localization activities, is widely seen in successful Internet ventures. Our research proposal aims to explore how these capabilities can help late entrants in Internet ventures achieve better growth rates than the pioneers. Furthermore, we also explore the organizational theory approach that discusses the role of new venture team prior experience and entrepreneurs' social networks, especially business resources networks, as the factors that help in the development of platform envelopment capabilities.
KETERAMPILAN METAKOGNITIF SISWA SMA NAHDLATUL WATHAN MATARAM PADA MATAPELAJARAN BIOLOGI
Authors: R. Didi Kuswara  , Lume  , Fauzi Haryadi  , Mahnep  , L. Ependi  , Nadzar Abd. Basith  , Eka Marta Rahayu
Published: April 2024

Penelitian ini bertujuan melihat gambaran secara umum keterampilan metakognitif siswa kelas X SMA Nahdlatul Wathan (NW) Mataram yang terdiri dari kelas X MIA dan X IIS. Jenis penelitian ini ialah kualitatif dengan pendekatan deskriptif. Data yang dihasilkan berbentuk statistik deskriptif dan verbal dengan tujuan untuk mendeskripsikan kemampuan metakognitif siswa khususnya pada matapelajaran biologi. Pengambilan data dilakukan dengan kuesioner keterampilan metakognitif siswa dari tiga aspek yakni perencanaan (planning), pemantauan (monitoring), dan evaluasi (evaluation). Berdasarkan ketiga aspek tersebut menunjukkan bahwa siswa kelas X SMA NW Mataram belum memiliki keterampilan metakognitif yang berkembang dengan baik bahkan dalam kategori rendah. Berdasarkan hasil penskoran kuesioner didapatkan bahwa lebih banyak siswa menjawab kadang-kadang (40.8%) pada aspek perencanaan, bahkan tidak pernah (40%) pada aspek pemantauan, kecuali pada aspek evaluasi 58.3% menjawab sering. Hal ini menunjukkan bahwa kesadaran mereka untuk melakukan perencanaan dan pemantauan terhadap proses belajarnya sangatlah rendah dan tentu hal ini berdampak pula terhadap hasil belajar. Namun tentu kesadaran mereka untuk mengevaluasi belajarnya menjadi dasar yang baik untuk perbaikan hasil belajarnya. Atas dasar inilah yang mengharuskan guru mampu merancang pembelajaran yang mengarah pada memaksimalkan dan meningkatkan metakognitif siswa.
PENGEMBANGAN MULTIMEDIA CHATBOT UNTUK MEREMEDIASI MISKONSEPSI PESERTA DIDIK
Authors: Aulia Novitasari  , Rekha Azhra Fauza  , Meita Dwi Solviana
Published: April 2024

Konsep merupakan aspek krusial yang harus dimiliki oleh peserta didik. Konsep yang tidak sesuai mengakibatkan munculnya konsep baru, jika tidak atasi dengan baik, konsep tersebut tetap menjadi bagian dari struktur kognitif dan menyebabkan miskonsepsi yang berdampak pada pemahaman materi lainnya. Tujuan penelitian ini mengetahui prosedur pengembangan, kelayakan, dan keefektifan multimedia chatbot untuk meremediasi miskonsepsi peserta didik kelas XI pada materi sistem gerak manusia. Jenis penelitian ini yaitu Research and Development (R&D) menggunakan metode ADDIE dengan tahapan yaitu analyze, design, development, implementation, dan evaluation. Teknik pengumpulan data yakni angket validasi dan angket respon terhadap multimedia chatbot, dan tes diagnostik miskonsepsi. Analisis data menggunakan kategori tingkat miskonsepsi, uji independent sample t-test, dan uji N-Gain. Spesifikasi produk chatbot berisi gambar, video, audio, materi sistem gerak manusia, dan menu tambahan yakni petunjuk penggunaan, rangkuman, peta konsep, profil pengembang, glosarium, dan latihan. Hasil kelayakan menunjukkan kategori sangat layak dari validasi ahli materi, media, bahasa, dan juga angket respon peserta didik. Keefektifan dilihat dari N-Gain pada kelas eksperimen lebih tinggi dibandingkan kelas kontrol. Hasil tes diagnostik menunjukkan tingkat miskonsepsi peserta didik kelas eksperimen lebih rendah dibandingkan kelas kontrol, yang artinya multimedia chatbot sangat layak dan efektif untuk meremediasi miskonsepsi peserta didik.
Measuring the efficiency of the Republic of Korea’s cultural diplomacy in Vietnam under Moon Jae-in’s presidency (2017-2022) and its potentialities
Authors:   Department of Liberal Arts Education, University of Management and Technology, Ho Chi Minh City, Vietnam, Ha Trieu Huy
Published: April 2024

As soon as the new president of the Republic of Korea was elected in 2017, Moon Jae-in anchored the New Southern Policy (NSP), which targeted southern Asian countries and expanded South Korea’s strategic presence in the Asia-Pacific Ocean. As such, the ROK continued to adopt a public diplomacy policy and empowered Korean culture in Southeast Asian countries, including Vietnam. This article aims to generalize Moon Jae-in’s policy on cultural diplomacy and his application in Vietnam as a case study. I employed Joseph Nye’s soft power and cultural diplomacy concept while adopting a qualitative method to collect official information from the ROK’s homepages and assess diplomatic results. The central argument of this article is that Moon Jae-in considers cultural diplomacy a key element of the NSP for promoting Korean culture and bolstering a strategic presence in Vietnam and Southeast Asia. The ROK attempted to graft K-pop, movies, Korean customs, Korean languages, and Korean cuisine onto the Vietnamese concept and seek an upgrade of Vietnamese Korean cultural exchanges and the frequent organization of cultural events. Hence, an upgrade between the ROK and the Socialist Republic of Vietnam (SRV) to a Comprehensive Strategic Partnership in December 2022 marked an achievement of cultural diplomacy. I also argued that this attempt has a tonic effect on continuing the ROK cultural diplomacy under Yoon Suk Yeol’s presidency and on the foreseeable chance of both the SRV and the ROK in cultural diplomacy.