bluuebunny/crossref_metadata_2025 huggingface dataset:
Violence between residents: striking a balance
Authors: Ponting Stuart , Elsom Lucy
Published: May 2018

Violent outbursts and assaults are a common occurence in care homes. Stuart Ponting and Lucy Elsom explore the legal implications of this kind of behaviour, the potential causes and ways for care home managers to prevent violence.
‘Having fun, getting fit’
Authors: Hardaker Steve
Published: May 2018

Headteacher and sports co-ordinator Steve Hardaker explains how the Premier League Super Movers programme has become part of his school's ‘physical diet’.
How are we feeling?
Authors: Hamblin Lyn
Published: May 2018

Lyn Hamblin, a former school leader of student wellbeing, provides some practical strategies to build both staff and pupils' emotional intelligence skills in the classroom.
La decoración pictórica del Municipium Urbs Victrix Osca (Huesca)
Authors: Guiral Pelegrín Carmen , Íñiguez Berrozpe Lara María , Justes Floría Julia , Fuchs Michel
Published: May 2018

En este estudio se analizan cuatro conjuntos pictóricos hallados en la excavación urbana realizada en la calle Dormer nº 8-10. El primero presenta zócalo con imitaciones marmóreas y zona media en la que alternan paneles anchos y estrechos; un friso decorado con flores de loto estilizadas debía corresponder al remate superior de la pared. El segundo conjunto es el que ofrece un mayor interés; el zócalo presenta una serie de placas que imitan mármoles de distintas variedades y en la zona media se desarrolla un sistema de relación continua sobre fondo negro. Del tercero únicamente se conserva un zócalo moteado y, finalmente, el último conjunto muestra un fondo blanco decorado con filetes rojos que articulaban una serie de paneles; el interés radica en la presencia de un graffito con una serie de numerales. La cronología de las pinturas, a tenor de los datos arqueológicos y los derivados del estudio estilístico, puede establecerse en la segunda mitad del s. I d.C.
Estudio de fenómenos consonánticos de la lengua íbera
Authors: Rodríguez Ramos Jesús
Published: May 2018

El objetivo de este artículo es el estudio de algunos fenómenos del consonantismo de la lengua íbera. El principal punto de partida para la selección de los casos de estudio lo constituyen principalmente las alternancias gráficas en la escritura de determinadas palabras y segmentos, así como la presencia de combinaciones de letras/fonemas excepcionales.
¿Cuándo cambia un sistema de partidos? Una perspectiva de análisis electoral desde el caso de Colombia
Authors: Basset Yann
Published: May 2018

Este artículo estudia el cambio del sistema de partidos colombiano utilizando una perspectiva de análisis electoral. Mediante un análisis de componentes principales, identifica las estructuras territoriales del comportamiento electoral del país en las elecciones del Senado en las dos pasadas décadas. Muestra que la reforma política de 2003 incentivó la reorganización del sistema de partidos reproduciendo el tradicional eje liberal/conservador, aun expresado mediante un sistema multipartidista. Las elecciones de 2014 sugieren un cambio más profundo.
Bailando con Zizek: orígenes y evolución de la cumbia digital en Buenos Aires
Authors: Vázquez Márquez Israel
Published: May 2018

Este artículo trata sobre una de las manifestaciones musicales más originales e innovadoras del nuevo siglo: la denominada «cumbia digital». Se trata de una nueva etiqueta musical empleada en tiempos recientes como una manera de referirse a un nuevo tipo de cumbia de carácter postmoderno y digital, que está siendo interpretada por una nueva generación de músicos argentinos que han crecido en la era de Internet. El artículo traza la historia de este particular tipo de cumbia, desde sus orígenes hasta la actualidad, prestando especial atención al papel de la tecnología digital en el desarrollo y evolución de esta escena.
Ingesta de calcio y relación con el sobrepeso y obesidad en adolescentes mujeres, Ecuador
Authors: Barahona-Meneses Amparito del Rosario , Barahona-Meneses Amparito del Rosario , Castillo-Andrade Rocío Elizabeth , Espín-Capelo Magdalena , Folleco-Guerrero Juan Carlos , Criollo-Ibujes Johanna , Hidrobo-Guzman José Fabian
Published: May 2018

Introducción: El consumo de calcio en la dieta, en particular el proveniente de lácteos, se asocia con la reducción de masa grasa y peso corporal. El objetivo fue evaluar la ingesta de calcio y su relación con el sobrepeso y la obesidad en adolescentes mujeres (14-19 años) de Ecuador, entre 2015 y 2016. Material y métodos: El estudio fue descriptivo, analítico, transversal y correlacional. El estado nutricional se evaluó en 1211 adolescentes mujeres utilizando los indicadores IMC/edad, talla/edad, porcentaje de grasa y circunferencia de la cintura; la ingesta de calcio se midió en una muestra de 294 adolescentes diagnosticadas con sobrepeso y/u obesidad a través del método recordatorio de 24 horas y el cuestionario de frecuencia de consumo alimentario. Resultados: el 21,1% del total de la población presentó sobrepeso y 4% obesidad según IMC/edad y 28,7% sobrepeso, 7,9% obesidad según porcentaje de grasa. El indicador talla/edad determinó 30% de retardo en talla. La ingesta promedio de Ca fue 403,5 mg/día, No se encontró una relación significativa entre la ingesta de Ca determinado por R24H ni FFC y la adiposidad. Se encontró asociación significativa entre la adecuación de calcio y el IMC. Conclusiones: no existe relación entre la ingesta de calcio y el incremento del tejido graso en las adolescentes analizadas.
Declaración de Sant Joan d’Alacant en defensa del Acceso Abierto a las publicaciones científicas, del grupo de editores de revistas españolas sobre ciencias de la salud (GERECS)
Authors: Grupo Editores Revistas Españolas sobre Ciencias de la Salud (GERECS)
Published: May 2018

Este documento se publica simultáneamente en las revistas que han suscrito la Declaración de Sant Joan d’Alacant del Grupo de Editores de Revistas Españolas sobre Ciencias de la Salud (GERECS) el día 25 de noviembre de 2017.
Isolation and Testing of Bacteria from Steroid Compounds obtained from Anting-anting Leaf (Acalypha indica L.)
Authors: Fauzia Ditya Vega , Kusrini Dewi , Fachriyah Enny
Published: May 2018

Isolation of steroid compounds from the leaves of the earrings (Acalypha indica L.) and the antibacterial test has been performed. This study aims to obtain information about secondary metabolite compound leaves of Anting-anting, obtaining and identifying steroid isolates from the leaves of Anting-anting and knowing the antibacterial activity of the positive fraction of steroid compounds. The research stages include sample preparation, phytochemical test, isolation, separation, purification of steroid compounds, identification of steroid isolates using LC-MS/MS, and antibacterial test by paper disc method. The results of phytochemical screening show that the leaves of the earrings contain alkaloid compounds, flavonoids, steroids, saponins, tannins, and quinones. From the results of steroid isolation, we found steroid isolates weighing 0.0065 grams (0.0058%). Identification of steroid isolates using LC-MS/MS at a retention time of 7.49 min with [M+H]+ 399 m/z indicated the presence of a brassicasterol compound. The results of antibacterial test of fraction A from chloroform extract containing steroid compound showed antibacterial activity against Staphylococcus aureus bacteria and Escherichia coli bacteria.
MicroRNA-200 as potential diagnostic markers for colorectal cancer: meta-analysis and experimental validation
Authors: Peng Zongyu , Zhu Wenru , Dai Jinzhao , Ju Fang
Published: May 2018

Members of microRNA(miR)-200 family is proposed as promising biomarkers for colorectal cancer (CRC). However, their expression in CRC patients, and whether them could identify as new biomarkers of cancers are inconsistent and controversy. Therefore, a meta-analysis was performed to assess the diagnostic value of miR-200 family members in CRC patients. This meta-analysis screened 6 studies, including 191 patients with colorectal cancer at stage IV, 446 patients with colorectal cancer at stage I~III and 98 normal controls, and performed using bivariate and hierarchical summary receiver operating characteristic (HSROC) models. The quality of the eligible studies was assessed according to Quality Assessment of Diagnosis Accuracy Studies-2. The pooled sensitivity and specificity of miR"‘141 alone for CRC diagnosis were 82% and 75%, respectively. The diagnostic odds ratio (DOR) value was 13.21 [95% confidence interval (CI), 7.00"‘24.95], and the area under the curve (AUC) was 0.85 (95% CI, 0.82"‘0.88). The pooled sensitivity and specificity of total miR-200 family members were 79% and 71%, respectively. In the HSROC model, the estimate for the "Lambda" was 2.48 (95% CI,1.50-3.46). Finally, we detected the miR-141 in 20 CRC patients and 20 healthy. Results showed that serum miR-141 was overexpressed in CRC patients. Overall, miR-141 in miR-200 family has a good sensitivity and moderate specificity for CRC diagnosis.
A meta-analysis of microRNA-17 as a potential biomarker in diagnosis of colorectal cancer
Authors: Liu Tao , Yin Libin , Yan Guoqiang , Li Chao , Wang Lei
Published: May 2018

This meta-analysis was aimed to determine the diagnostic accuracy of circulating microRNA-17 for colorectal Cancer (CRC). Databases including PubMed, Embase, Web of Science, Cochrane Library and China National Knowledge Infrastructure (CNKI) were searched up to February 23, 2018 for eligible studies. Quality Assessment of Diagnostic Accuracy Studies (QUADAS) was employed to assess the quality of the included studies. Meta-analysis was performed in STATA 13.0. Ten studies with total 938 CRC patients and 638 control individuals were included in this meta-analysis. All of the included studies are of high quality. The summary estimates revealed that the pooled sensitivity is 0.75 (95% confidence interval (CI): 0.60–0.85) and the specificity is 68% (95% CI: 0.56–0.77), for the diagnosis of CRC. In addition, the area under the summary ROC curve (AUC) is 0.76. The current evidence suggests that circulating miR-17 has the potential diagnostic value for CRC. More prospective studies on the diagnostic value of circulating miR-17 for CRC are needed in the future. Together, microRNA-17 might be a novel potential biomarker in the diagnosis of colorectal cancer, and more studies are needed to highlight the theoretical strengths.
Bacillus Calmette Guérin (BCG) activates lymphocyte to promote autophagy and apoptosis of gastric cancer MGC-803 cell
Authors: Yao Keyu , Wang Wei , Li Haicheng , Lin Jinfei , Tan Weiguo , Chen Yuhui , Guo Lina , Lin Dongzi , Chen Tao , Zhou Jie , Zhai Shuangqing , Yu Weiye
Published: May 2018

Bacillus Calmette Guérin (BCG) has a potential anti-tumor effect on gastric cancer. However, the mechanism is still unclear. In this study, we investigated the effect of BCG on gastric cancer cell line MGC-803 and studied the potential cooperation of BCG and lymphocyte in determining the final fate of cancer cells. After treatment with BCG, the cell viability was significantly inhibited in a dosage-dependent manner. Flow cytometry assay showed the apoptosis rates were significantly increased by BCG. Using western blot assay, results showed that BCG increased cleaved-caspase-3, LC-3BII and Atg-3. After cocultured with BCG and lymphocyte, the apoptosis rates, the levels of cleaved-caspase-3, and the protein levels of LC-3BII and Atg-3 were significantly increased compared with BCG or lymphocytes alone groups. ELISA detection found that BCG induced secretion of interferon gamma (IFNg) from lymphocytes. BCG with IFNg also increased levels of cleaved-caspase-3, LC-3BII and Atg-3. Taken together, BCG promotes lymphocyte immunocompetence to induce cell apoptosis and autophagy in MGC-803 cells, might through inducing release of IFNg from peripheral blood lymphocytes.
Luteolin promotes the sensitivity of cisplatin in ovarian cancer by decreasing PRPA1-medicated autophagy
Authors: Liu Qing , Zhu Dongchuan , Hao Baozhen , Zhang Zhiwei , Tian Yongjie
Published: May 2018

Luteolin (LUT) is a flavone universally presented in plants. It shows an anti-carcinogenic effect in different cancers and could increase the sensitivity of cisplatin in colorectal cancer cell lines through Nrf2 pathway. However, the effect of luteolin on the sensitivity to ovarian cancer cells has not been studied. In this study, luteolin was found to suppress autophagy with reduced expression of LC3-II, but enhanced the inhibition of cell vitality and promoted apoptosis induced by cisplatin, leading to restoration of the sensitivity to cisplatin in ovarian cancer cells through CCK-8, flow cytometry and immunofluorescent assays. Although cisplatin elevated the PARP1 for cell survival, the cisplatin-induced expression of PARP1 was inhibited by luteolin a dose- and time- dependent manner through Q-PCR and WB assays. Further, PARP1 siRNA could further improve the LUT-induced inhibition of cell vitality and restore the sensitivity to cisplatin with reduced LC3-II levels. Our present work demonstrate that LUT can suppresses autophagy but enhance apoptosis induced by cisplatin and promote the sensitivity to cisplatin through suppressing the expression of RARP1 in ovarian cancer.
Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells
Authors: Xia Xiaoyan , Zhou Xiaoming
Published: May 2018

Cervical cancer (CC), a common gynecological cancer, is a primary cause of cancer-related death in women, worldwide. This study investigates the role of Sirtuin 1 (SIRT1) in paclitaxel (PTX)-resistant CC lines. We used qPCR and Western blots to measure SIRT1 mRNA and protein expressions in 10 matched clinical cancer tissues. We compared the expression levels of SIRT1 between sensitive CC cell lines and PTX-resistant cell lines. Subsequently, we used SIRT1 siRNA to knockdown the expression of SIRT1, and then measured cell proliferation, cell apoptosis rate, cell cycle distribution, and expression levels of Bcl-2 and Bax in PTX-sensitive Hela cell line, PTX-resistant Hela and Sila-resistant cell lines. Finally, we detected the location and expression of MRP (multidrug resistance-associated proteins) using immunofluorescence. We found that SIRT1 expression was higher in PTX-sensitive CC tissues than in normal tissues, and significantly higher in PTX-resistant CC tissues than in PTX-sensitive CC tissues. We further demonstrated that knockdown of SIRT1 in PTX-resistant CC cell lines and PTX-sensitive CC cell line inhibited cell proliferation and promoted cell apoptosis. In addition, we observed that blocking SIRT1 expression in PTX-resistant CC cell lines significantly decreased MRP expression. SIRT1 exhibited high expression levels in both PTX-resistant cell lines and patients. Our results suggest that SIRT1 serves as a potential therapeutic target in PTX-resistant CC.
Visfatin increases miR-21 to promote migration in HCC
Authors: Liang Ninglin , Chen Yongjun , Yang Li , He Suyu , Liu Tianyu
Published: May 2018

Hepatocellular carcinoma (HCC) is a common human malignancy. In this study, we aimed to investigate the serum levels of visfatin and miR-21 in HCC patients, to analysis the relationship between the pathological features and the plasma level of visfatin or miR-21, and to explore the roles of visfatin and miR-21 in migration of HCC cells. Our results showed that the serum levels of visfatin and miR-21 were significant higher in HCC patients than healthy subjects. The diagnostic sensitivity of serum visfatin was 82.5% and the specificity was 65.0%. The serum visfatin was significantly associated with the histology and metastasis. Visfatin induced miR-21 expression and cell migration in HepG2 cells. Transfection of miR-21 inhibitor suppressed the visfatin-induced migration in HCC cells. These results suggested that visfatin induced HCC cell migration via upregulation of miR-21, which provides a novel basis for the diagnosis of HCC.
Modeling of Air Permeability of Knitted Fabric Using the Computational Fluid Dynamics
Authors: Puszkarz Adam K. , Krucińska Izabella
Published: May 2018

This article concerns the widespread matter of biophysical comfort. In this work, 10 double-layer knitted fabrics with potential application in multilayer garments addressed to a specific group of users, such as newborns, were investigated. The materials were constructed with the following raw materials: cotton, polypropylene, polyester, polyamide, bamboo, and viscose. The textiles with a comparable geometrical structure and different composition were tested for their air permeability. In the experimental part, the materials were tested in specific constant ambient conditions using an air permeability tester. In the simulation part, 3D models of actual textiles were designed and air permeability based on the performed simulations using finite volume method was calculated. Both measurements and simulations yielded comparable results and showed that the air permeability of the knitted fabric strongly depends on the thickness and geometrical parameters of yarn.
Investigation on Thermal Comfort Characteristics of Regenerated Bamboo and Cotton Woven Structured Fabrics
Authors: Abro Zamir Ahmed , Chen Nanliang , Yifan Zhang , Cheng-Yu Hong , Abassi Abdul Malik Rehan , Simair Altaf Ahmed , Ahmed Rafique , Hussain Azmat
Published: May 2018

In this research work, thermal properties of plain woven fabrics generated from regenerated bamboo and cotton fiber blended yarns were investigated. Seven mixtures of fiber (100% bamboo, 100% cotton, 10:90 bamboo: cotton, 20:80 bamboo: cotton, 30:70 bamboo: cotton, 40:60 bamboo: cotton and 50:50 bamboo: cotton) were developed to create 60 Tex ring spun yarn. The warp yarns were used as 100% regenerated bamboo and the bamboo: cotton blends were used alternatively in weft to produce plain woven fabrics. The plain structured woven fabrics show eminent thermal comfort properties with the blending of regenerated bamboo fibers. The air permeability of 100% regenerated bamboo fiber was recorded higher than the compared blends; the increased key factor contents of bamboo changed the air properties of the fabric. Furthermore, plain woven fabric of bamboo/cotton (50/50) has shown greater thermal conductivity and heat retention properties. The work reported in this paper is ensuring highpoints of thermal comfort properties of regenerated bamboo (100%) and cotton (100%) with plain woven structured fabrics, and potentially, the fabrics can be used for winter suiting apparel products.
Storylab Lessons
Authors: Hultén Gunilla , Picha Edwardsson Malin
Published: May 2018

This article examines Storylab, a collaborative learning project between the journalism programme at Stockholm University and the engineering programme in media technology at the KTH Royal Institute of Technology in Stockholm, designed to combine journalistic storytelling with pervasive media technology. The aim of the study is to identify and reflect on the challenges associated with the approach. The methods used are a survey and semi-structured interviews with the students. The analyses draw on research concerning the current main challenges for the news industry and journalism educators. The results show that Storylab was highly appreciated, and provided students with useful skills for their professional lives. However, not all groups worked well together, and some students wished that the collaboration had been more extensive. Differences in motivations and priorities were mentioned as restraining factors. Therefore, it is argued that for a sustainable media landscape, journalists and engineers must collaborate, and that this cooperation can be brought about during professional training.
Assessing Students’ Ethnicities and Critical Thinking Skill to Develop PBL Based-Biology Learning Tools
Authors: Boleng Didimus Tanah , Lumowa Sonja V.T. , Palenewen Evie
Published: May 2018

A survey has been conducted in grade XI natural science of senior high school, at odd semester, academic year 2016/2017 in Samarinda, Indonesia. The focus of this research are to determine the students’ ethnicities, and the responses of biology teachers about students' critical thinking skills, and Problem-Based Learning. Sampling technique was total sampling. The research instrument was a questionnaire. Data was analysed by techniques used descriptive. The results of the data analysis show that the compositions of students’ ethnics are: Java (12.7%), Bugis (6.9%), Kutai (13.3%), Banjar (13.3%), and other ethnics (28.5%). Most of the teachers (86.0%) who already understood about the learning approaches, said that they already understood, while the remaining 14% did not understand the patterns of Problem-Based Learning. In addition, 23.3% teachers said that students were less able to explain, express opinions, and make conclusions; 76.7% said that students are sufficiently able to explain, express opinions, and make conclusions. Future research related to biology learning in multiethnic students needs to be conducted to get more information. The design of learning tools needs to consider the ethnic  of the students in strengthening critical thinking skills. Similar research needs to be done to obtain more information.The findings of this research are the students’ ethnicities of the XI class of Natural Sciences, as well as the responses of high school biology teachers about students' critical thinking skills in Biology.
Antioxidant Potential of Ethanol and Ethyl Acetat Extract of Ganoderma sp. Mycelium
Authors: Ratnaningtyas Nuniek Ina , Purnomowati Purnomowati , Purwati Endang Sri , Septiana Aisyah Tri , Ekowati Nuraeni , Supriyadi Adi
Published: May 2018

Ganoderma sp. Banyumas 1 isolate that reffered as Ganoderma sp. is a new discovered isolate from Banyumas, Central Java, Indonesia expected to have a potential properties of antioxidant of medicinal mushroom. This study aimed to determine the antioxidant potential and the appropriate solvent for it’s extracting from Ganoderma sp. This research result showed that ethyl acetate was able to extract as many as 15.57%, while etanol was only able to extract 3.87% active compounds from dried 28 days old Ganoderma sp. mycelium cultivated in the Mushroom Complete Medium (MCM). Extract of ethyl acetate (non-polar) extraction of mycelium of Ganoderma sp. had a potential character as an antioxidant source and performed a better result than from ethanolic (polar) extraction as shown in the IC50 value. Extract from ethyl acetate extraction had an average IC50 value smaller than  from ethanolic extract (581.80 < 1285.67). Extract from ethyl acetate extraction resulted in a higher amount of phenol than that ethanolic extract 29.23 < 57.67. Inhibition percentage of both extracts at 65% was known to occur at concentration of 1000 ppm for ethyl acetate extract and 2000 ppm for ethanolic extract. An important finding was that ethyl acetate can be used as appropriate solvent for extracting antioxidant compound better than ethanolic. In conclusion, the mycelium extract of Ganoderma sp. extracted with ethyl acetate and ethanol as solvent is potential to be used as a source of natural antioxidants. This research result has benefit in developing potency of local resources as herbal resources.
Mahameru Soybean (Glycine max) Cultivar, High Salinity Tolerant
Authors: Juwarno Juwarno , Suparjana Tata Brata , Abbas Muachiroh
Published: May 2018

Mahameru cultivar is high salinity tolerant cultivar. The previous study result showed Mahameru cultivar could tolerate 140mM NaCl, but Cilacap Coast salinity levels often reaching 200mM NaCl. A research of salinity stress on Mahameru cultivar at 200 mM NaCl have not conducted yet. Therefore to conduct the research of Mahameru at high salinity stress to obtained high salinity tolerant soybean cultivar.   The observed variables are anatomy (epidermis thickness, the density of stomata and trichomes, palisade thickness) physiology (the dry weight of roots and canopy, the content of chlorophyll a and b) Production (whole pod, total filled pod, total empty pod, weight per one-hundred beans). The salinity treatment was 0, 50,100, 150, 200 mM NaCl given at three days before planting and twenty-one days after planting. The data of anatomy and physiology was taken at forty-five days after planting. The production data was taken when soybean plants turned brown. The result indicates that salinity affects anatomy characteristic of leaf, higher the salinity increasing epidermis thickness and the density of stomata and trichomes. Salinity affected the content of chlorophyll a and b. Higher the salinity increased the content of chlorophyll a and b. Salinity did not affect soybean production. Based on this study Mahameru cultivar is resistant to salinity up to 200 mM NaCl. The benefit of this research help to enhance national soybean production with utilization coastal land for soybean planting Mahameru cultivar.
Antioxidant Effect of Clorella vulgaris on Wistar Rat Kidney Induced by CCl4: A Histopathological Review
Authors: Susatyo Priyo , Rifanda Achmad Akbar , Simanjuntak Sorta Basar Ida , Chasanah Titi
Published: May 2018

Kidney is very susceptible to damage by toxicological compounds such as carbon tetrachloride (CCl­4). CCl4 produce free radicals, which cause lipid peroxidation and kidney damage and free radical release, which can be prevented by the administration of exogenous antioxidants, such as Chlorella vulgaris.The aim of study was to determine an effect of antioxidant of C. vulgaris on the histopathological features of Wistar rat  kidney which is induced by CCl4. Experimental study with completely randomized design. The variable was histopathology features of the kidneys. The doses of C. vulgaris extract were 3 mg, 4 mg, and 5 mg per 100 grams of rat body weight (BW). The administration of C. vulgaris extract was performed within 30 days, while the CCl4 induction (0.25 ml / 100 g BW) was administered orally on the day 9, 12, 16, 19, 23, and 26. Parameters were histopathology features of renal damage, proportion of tubular cell damage, and Bowman's space diameter. The results showed the administration of C. vulgaris extract was able to reduce the impact of damage caused by CCl4 (p<0.05). This was supported by histologic observations, which was showing a decrease of picnotic and vacuolated cells, normal brush border, and decrease of Bowman's space. In conclusion, 5 mg / 100 g BW of C. vulgaris extract can effectively protect the kidney from damage        caused  by        CCl4. The results of this study strongly support further research on immunostimulant content test C. vulgaris and determine the efficient dose for representative animals mammals also in humans.
40 YEARS OF IGF1: PAPP-A and cancer
Authors: Conover Cheryl A , Oxvig Claus
Published: May 2018

The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.
O anxo negro (Encontro con Manuel Gago)
Authors: Ríos Santomé Soledad
Published: May 2018

Entrevista a Manuel Gago, autor da novela O anxo negro, na que nos presenta as claves da súa escrita.Cun estilo áxil e ameno e unha linguaxe coidada, o autor elabora unha novela coral e trepidante cunha mestura de tempos e espazos e de estilos. Novela histórica, negra, best-seller... Ese é o resultado.As claves, na entrevista co autor.
Perspectiva intergeneracional del juego como patrimonio cultural
Authors: Araya Góchez Adriana , Castro Pérez Marianella , Morales Ramírez María Ester
Published: May 2018

En el 2013 la Universidad Nacional y la Universidad de Costa Rica iniciaron la investigación “El juego como patrimonio cultural: percepción de las personas de diferentes generaciones en los cantones de Desamparados y Barva”, cuyo objetivo fue analizar el juego como patrimonio cultural, desde la percepción que tienen las personas de diferentes grupos generacionales de ambos cantones. Este escrito presenta los resultados del análisis intergeneracional, al contrastar las diferencias y similitudes relacionadas con las siguientes características del juego: conceptualización, importancia, valores que promueve, lugares donde sucede el juego, personas que lo acompañan y tipos de juegos. El enfoque de investigación fue mixto y el tipo fue descriptivo-explicativo ya que proporciona un sentido de entendimiento al juego como patrimonio. La población participante constó de 170 personas de Desamparados y 158 de Barva, conformada por estudiantes de primaria y secundaria, docentes, personas adultas y adultas mayores y representantes municipales, seleccionados según criterios de edad y rol que desempeñaban. Los datos fueron recolectados con cuestionarios que contenían ítes comunes y que estaban dirigidos con base en el grupo generacional. Los principales resultados refieren que el juego es considerado por todos los grupos generacionales como una actividad placentera, que promueve diversión, entretenimiento, disfrute, alegría, convivencia y socialización. El juego se visualiza como una actividad casi exclusivamente de y para los niños y las niñas, en pocas excepciones mencionan a las personas adultas o adultas mayores como sujetos participantes. Casi para la totalidad de la población, el juego es de suma importancia para el desarrollo integral, para el aprendizaje de conceptos y esencialmente de valores. Llama la atención que el juego no es visualizado como un derecho según lo establece la legislación.
El enfoque de derechos humanos en la atención de poblaciones vulnerables en contextos de emergencias y desastres de origen natural: experiencias en Costa Rica
Authors: Méndez Juan Carlos
Published: May 2018

El artículo analiza los alcances, limitaciones y experiencias en el uso del enfoque de derechos humanos en la atención de poblaciones vulnerables en situaciones de desastres y emergencias en Costa Rica, tomando como base experiencias recientes llevadas a cabo por la institucionalidad costarricense en materia de gestión de riesgos y atención de emergencias. Se analiza brevemente el desarrollo del concepto del enfoque de derechos humanos en esta materia, destacando los esfuerzos de la comunidad humanitaria en la incorporación de medidas tendientes a asegurar que las personas más vulnerables afectadas directamente por un desastre, puedan tener un acceso sin discriminación a la prestación de asistencia, en especial poblaciones históricamente en condiciones de vulnerabilidad tales como mujeres, niños y niñas, personas con discapacidad, migrantes y personas adultas mayores.
50 años de la Reforma Agraria chilena. De la protección a la vulneración de los derechos campesinos
Authors: Castañeda Meneses Patricia
Published: May 2018

El presente artículo se inscribe en el marco de la conmemoración de los 50 años de la Reforma Agraria chilena y tiene por objetivo analizar los procesos de Reforma Agraria y Contrarreforma Agraria, desde la perspectiva de la protección de los derechos campesinos. Estos derechos correspondían a acceso a la tierra, acceso a la asistencia técnica, acceso al crédito agrícola preferente, acceso a la comercialización, derecho de asociación sindical de los trabajadores agrícolas, e incluían los derechos sociales de educación, salud y vivienda. Su cumplimiento fue asumido por los organismos estatales y concretizado en una reforma constitucional y cuerpos legales que formalizaron el proceso y le dieron viabilidad como política del Estado. Se crearon organismos públicos definidos para apoyar la labor de redistribución de la propiedad agraria, se contó con recursos públicos declarados en el presupuesto nacional y con acciones intersectoriales destinadas a este importante grupo social. A partir del golpe de Estado de 1973 se inicia un proceso de Contrarreforma Agraria que vulneró progresivamente los derechos campesinos. La tierra fue entregada en forma individual, sin asistencia técnica estatal ni acceso preferente al crédito agrícola y se abandonaron las acciones destinadas a garantizar derechos sociales. Como resultado, se estima que más del 50% de las tierras asignadas a campesinos fueron vendidas, creando un mercado agrario de tierras y de mano de obra rural que es la base del actual capitalismo chileno agroexportador.
Biological evaluation of the rationality of soil usage in agriculture
Authors: Bulyhin S. , Tonkha O.
Published: May 2018

Aim. To perform biological evaluation of 60-year-long application of different variants of fertilization in terms of the number of microorganisms, transforming the compounds of nitrogen and carbon. Methods. Microbiological methods – determining the number of microorganisms, transforming the organic compounds and nitrogen, statistical processing. Results. It was determined that the application of a crop rotation with legumes and the variant with complete mineral fertilization on meadow-chernozem carbonate soils formed a balanced composition of microbial cenosis and the most optimal conditions for humus accumulation and nitrogen transformation. Conclusions. The microbiological monitoring demonstrated that it is possible to achieve non-degradation development of meadow-chernozem soil at the quasi-stable level in case of applying the 10-fi eld crop rotation with legumes (clover) and complete mineral fertilization.
Sociologia no Ensino Médio: institucionalização da disciplina e produção científica sobre o tema
Authors: Leite Kelen Christina , Martins Marcos Francisco , Corrochano Maria Carla , Da Silva Carolina Modena
Published: May 2018

Este artigo teve por objetivo assinalar o processo de institucionalização da Sociologia no ensino médio brasileiro, marcada pela intermitência entre obrigatoriedade, facultatividade e completa ausência da disciplina nas escolas. Para tanto se fez um rápido histórico da Sociologia no ensino médio, discutiu-se os desafios postos à área da Sociologia e das Ciências Sociais no que tange ao ensino da disciplina. Buscou-se, ainda, mapear a produção acadêmica acerca da Sociologia no ensino médio a partir das publicações de trabalhos apresentados nos Congressos da ANPOCS (Associação Nacional de Pesquisa e Pós-Graduação em Ciências Sociais), da ANPED (Associação Nacional de Pós-Graduação e Pesquisa em Educação) e da SBS (Sociedade Brasileira de Sociologia). Conclui se que os desafios postos para o campo são inúmeros, dentre eles destacam-se: a discussão sobre os cursos de graduação e a relação entre bacharelado e licenciatura; a questão do currículo da disciplina; materiais didáticos; poucas horas aula no ensino médio e a necessidade de consolidação de uma área de pesquisa específica sobre ensino de sociologia não apenas em Programas de Educação, mas, sobretudo nos Programas de Sociologia e/ou Ciências Sociais.
Innovación y enseñanza. De la “moda” de innovar a la transformación de la práctica docente
Authors: Sancho-Gil Juana M.
Published: May 2018

El mundo está constituido por un conjunto de cambios permanentes y el ámbito de la educación no es una excepción. Este artículo comienza situando las (in)constancias del cambio, sus derivas y paradojas y sigue con un breve apunte sobre la evolución de las ideas educativas, para plantear los desafíos que supone el imperativo de la innovación en el momento actual. A partir de ahí, se argumenta que ir más allá de la innovación como “moda”, requiere una profunda transformación de la práctica, para lo que se precisa tener en cuenta cinco elementos clave: quiénes son los docentes y estudiantes, cómo aprenden y cuáles son sus necesidades; qué tipo de conocimiento se considera importante enseñar para que al alumnado le resulte personal y socialmente valioso; qué tecnologías educativas se tendrían que utilizar o desarrollar para contribuir a alcanzar las finalidades planteadas; qué experiencias de aprendizaje habría que implementar para promover la implicación de los estudiantes y el sentido de aprender; qué sistemas evaluación se necesitan para dar cuenta del aprendizaje realizado.***Inovação e ensino. Da “moda” de inovar à transformação da prática de ensino***O mundo é constituído por um conjunto de mudanças permanentes, e o campo da educação não é uma exceção. Este artigo começa por situar as (in)constantes mudanças, suas derivações e paradoxos, e continua com uma breve nota sobre a evolução das ideias educacionais, para elevar os desafios que o imperativo da inovação no momento presente supõe. A partir daí, argumenta-se que ir além da inovação como “moda” exige uma transformação profunda da prática, para a qual é necessário levar em consideração cinco elementos-chave: quem são professores e alunos, como aprendem e quais são suas necessidades; que tipo de conhecimento é considerado importante ensinar para que os alunos o percebam como pessoalmente e socialmente valioso; quais tecnologias educacionais devem ser usadas ou desenvolvidas no sentido de contribuir para alcançar os objetivos declarados; quais experiências de aprendizagem são convenientes implementar para promover o envolvimento dos alunos e seu senso de aprendizagem; quais sistemas de avaliação são necessários para explicar o aprendizado alcançado.
A nova gestão pública: alguns impactos nas políticas educacionais e na formação de professores
Authors: Cóssio Maria De Fátima
Published: May 2018

Este artigo visa a analisar o contexto em que emergem as políticas educacionais, sobretudo aquelas voltadas à formação de professores. Defende-se a tese de que as reformas educacionais dos últimos anos, asseveradas recentemente, fazem parte das transformações do papel do Estado, em que se situa a Nova Gestão Pública (NGP) e o atual modelo de globalização neoliberal. Com vistas à modernização da gestão pública, superando a administração burocrática, considerada ineficiente, a NGP implica, entre outros fatores, introduzir na máquina pública princípios e práticas do setor privado (gerencialismo). Ao mesmo tempo em que propõe as parcerias com outros setores/entes para a execução de ações antes exclusivas do Estado (governança). O argumento é que o Estado, entendido como monolítico e centralizado, também não atende aos desafios da sociedade. Esse cenário se torna adequado à nova privatização na/da educação (princípios privados no setor público) em todos os níveis e etapas da educação.
Convivência acadêmica e formação humana: dimensões de socialização no Ensino Superior
Authors: Stecanela Nilda , Marin Lucas Josias
Published: May 2018

O texto objetiva promover uma discussão sobre o conceito de convivência acadêmica e sua importância nos percursos da formação humana em nível de educação superior. A reflexão proposta busca sustentação teórica na teoria levinasiana da alteridade e dialoga com as contribuições de Buber e Melucci sobre a relação e o processo de indentização do Eu. O cenário e dados empíricos da pesquisa que origina o texto consideram as concepções de convivência acadêmica expressas de modo direto e indireto em duas versões do Plano de Desenvolvimento Institucional de uma Instituição Comunitária de Ensino Superior. Análise documental e análise de conteúdo foram os procedimentos evocados para a construção dos dados. Na tessitura do argumento contemplamos que a aprendizagem também se faz a partir da relação que os indivíduos estabelecem entre si e o seu entorno, caracterizando um processo de socialização que colabora na formação humana, numa dimensão de abertura e acolhimento do Outro. Nos achados do estudo, concluímos que a socialização ocorre em quatro dimensões: contraposição, onde não há aceitação do Outro; coexistência, onde o Outro coabita no mesmo ambiente, porém não há relação; inclusão, nível em que o Outro tem suas necessidades atendidas para permanecer no mesmo ambiente, porém não há relação e; convivência, nesse nível o Outro é aceito e acolhido na sua diferença, há relação.
O desenvolvimento profissional docente na contemporaneidade: implicações transformadoras para o ser e para o fazer
Authors: Dos Santos Bettina Steren , Spagnolo Carla , Stöbaus Claus Dieter
Published: May 2018

Este estudo apresenta um diálogo teórico acerca do desenvolvimento profissional docente e de suas implicações para a aprendizagem dos professores em uma perspectiva integrada entre os binômios pessoa/profissional e teoria/ prática. Tem como objetivo refletir sobre os distintos aspectos que compõem o desenvolvimento profissional e sobre as possibilidades de transformação para a qualidade na formação contínua dos professores. Caracteriza-se como uma pesquisa bibliográfica, de cunho qualitativo, a partir das discussões entre os autores embasadas nas leituras dos distintos materiais. Conclui que a formação continuada de professores precisa ser repensada e desenvolvida levando em conta as bases que fundamentam as ações das instituições de ensino. O desenvolvimento profissional, por esse viés, assume papel importante na constituição de espaços que proporcionam a escuta ativa, o entendimento do outro e a percepção da complexidade enquanto compreensão do todo, a partir das necessidades individuais e coletivas.
Entre la política exterior y la política interna. De la Proclama de la Neutralidad al Plan de Paz (1983-1989)
Authors: Cascante Segura Carlos Humberto
Published: May 2018

Desde el concepto de uso de la memoria oficial, este artículo analiza los objetivos políticos internos de la política exterior costarricense entre 1983 y 1989. Con tal fin, el texto pretende establecer los objetivos internos que los gobiernos del periodo bajo estudio pretendieron conseguir a partir de su política exterior, así como los instrumentos que emplearon con tales fines. Se concluye que la política exterior del periodo no puede verse únicamente desde el plano internacional, sino que tuvo importantes repercusiones dentro del ámbito nacional.
Uso sustentable de agostaderos y el sistema vaca-cría en el Noroeste de México
Authors: Alcalá Galván Carlos Hugo , Barraza Guardado Ramón Héctor , Ayala Álvarez Félix , Rueda Puente Edgar Omar
Published: May 2018

Livestock is an economic activity, dedicated to the breeding of animal species to take advantage of them and of its derivative products, as well as of livestock exploitation itself. However, when relating it to the sustainable use of natural resources in Northwest Mexico, there can be seen some situations that need to be addressed. The present study aims to analyze the production and conservation status of natural resources of beef cattle activity in the cow-calf system in Sonora, Mexico. The diagnosis was based on aspects of regionalization of livestock, the specific characteristics and issues of the systems, and the productive status of rangelands. The results showed that, despite the existence of signs of wildlife utilization and the importance of protecting the habitat status for livestock development in the state of Sonora, Mexico, it is important to implement a series of actions in order to increase the sustainable productivity of soil, soil water resources, the recovery of vegetation cover, improvement of livestock management practices, needs of research and technology transfer, as well as institutional linkage and training of professional human resources.
Respuesta foliar y radical del maíz a la fertilización biológica-química en un suelo Luvisol
Authors: Montejo Martínez David , Casanova Lugo Fernando , García Gómez Martín , Oros Ortega Iván , Díaz Echeverría Víctor , Morales Maldonado Emilio Raymundo
Published: May 2018

An alternative to replace the excessive use of chemical fertilizers is the use of soil microorganisms. In this regard, using nitrogen fixingbacteria (N) and mycorrhizal fungi may improve the growth of different crops. The objective was to evaluate the influence of Rhizophagus intraradices and Azospirillum brasilense, as well as the addition of chemical fertilizers on foliar and root response of maize crop in Luvisol soil. The study was conducted from October 2014 to January 2015 at the Technological Institute of the Mayan Zone, Quintana Roo, Mexico.A cornculture was established by a randomized complete block design, and four treatments with four replicates: Mycorrhiza and Azospirillum (MA), Mycorrhiza and Azospirillum + 50% chemical fertilizer, (MA + FQ50%), 100% chemical fertilizer FQ100%) in doses of 142-70-00 kg / ha and a control. Stem height and diameter of the plants were measured. In addition, the number and length of roots were monitored by means of the minirhizotron technique at five depths and at different ages of the plants. At the end of the experimental period, leaf and root biomass were quantified. Treatments of FQ100% and MA + FQ50% presented higher total height and higher stem diameter of the plants. Also, these showed the highest number and length of fine roots, compared to the other treatments. However, treatment with MA + FQ50% kept the highest amount of biomass at the end of the crop.
Áreas potenciales para el cultivo de girasol en condiciones de temporal en Guanajuato, México
Authors: López-Rocha Enrique , Mireles-Arriga Ana Isabel , Hernández-Ruíz Jesús , Ruiz-Nieto Jorge Eric , Rucoba-Garcia Armado
Published: May 2018

In Mexico, in the last five years, there was a 189.50 to 13 219.84 hectares increase in sunflower crop surface under rainfed conditions. Particularly, in 2016, in the state of Guanajuato, approximately 450 hectares were planted. Cultivation under rainfed conditions requires planning including bioclimatic variables to reach the optimal crop yield and development. This work aims to identify bioclimatic potential areas for sunflower cultivation under rainfed conditions in Guanajuato. In autumn-winter 2016, 45 sunflower fields (distributed in eleven towns) were monitored and stratified. Crop yield associated with maximum and minimum temperature, relative humidity, solar radiation, precipitation, and evapotranspiration were recorded. The data from fields with a higher yield than 1.89 t/ha were used to generate polygons with a saturation of 56 abundance points, to calculate the potential distribution using the Maxent software, with 23 bioclimatic variables as predictors. The variables with the highest contribution percentage to the potential distribution were: average temperature of the driest quarter, altitude, moisture regime, and edaphic profile. The potential areas for sunflower cultivation had a surface of 317 028 hectares where the predominant climate is sub-humid warm, the annual mean temperature is 20 °C, the annual mean rainfall is 600 to 800 mm, and the altitude ranges from 500 to 1500 masl.
Tratamiento analítico de la bifurcación de Hopf en una extensión del sistema de Lü
Authors: Calderón-Saavedra Pablo Emilio , Muñoz-Aguirre Evodio , Alvarez-Mena Jorge
Published: May 2018

En este artículo se hace un análisis de la bifurcación de Hopf del sistema tridimensional tipo Lorenz introducido por Xianyi Li y Qianjun Ou (2011), este análisis consiste en identificar una región de parámetros del sistema donde la bifurcación de Hopf es no degenerada y supercrítica, aspecto que no es abordado en el artículo de Xianyi Li y Qianjun Ou. Para lograr este objetivo se utiliza el Teorema de la Variedad Central y el Teorema de Hopf. Además, para ilustrar los resultados, se muestran gráficas de algunas trayectorias del sistema, las cuales fueron obtenidas mediante simulación numérica.