bluuebunny/crossref_metadata_2025 huggingface dataset:
Water Droplets Driven by the Giant Surface Potential of Organic Films
Authors: Tsujioka Tsuyoshi , Kawashima Hiroyuki , Koike Kenji , Matsumoto Naoki , Shen Junwei , Nakamura Shinichiro
Published: February 2025

Controlling droplet motion on solid surfaces presents significant challenges in chemistry, physics, and materials science, especially for potential applications in "lab-on-a-chip" technologies. Traditional methods, such as using electric fields produced by electrodes, often inadequately manage complex droplet motion. Here we show a novel approach utilizing giant surface potentials (GSPs) generated through customizable photopatterning during vacuum deposition. Water droplets move spontaneously due to the potential difference between the GSP surface and the surface where the droplet comes into contact, which has a reduced potential. Our study not only enhances droplet control but also improves the photostability of the surface potential. We identify the optimal conditions for GSP generation, achieved under vacuum-deposition conditions conducive to maximum enthalpy relaxation, and demonstrate its potential for creating customizable, complex droplet flow channels. These advances offer significant promise for microfluidic devices, medical diagnostics, chemical synthesis, and energy harvesting applications.
Patterns and trajectories of smart city scientific inquiry: Comparative insights from U.S. and China research proposals
Authors: LAI YUAN , Zhao Haoxiang
Published: February 2025

The integrated concept of “smart cities” has emerged as a key focus of contemporary research, yet efforts remain fragmented, split between technology-driven and human-centered approaches. This study leverages open data and large language models to analyze smart city research proposals funded by the National Science Foundation (NSF) in the U.S. and the National Natural Science Foundation of China (NSFC). Our findings reveal common scientific inquiries alongside divergent research trajectories shaped by national contexts, exposing a persistent tension between techno-centric priorities and human-oriented imperatives. This comparative analysis of two leading global economies provides new insights into the evolution of smart city research, highlighting both shared challenges and distinct pathways.
Ischemic injury and liver graft congestion increase post-transplant interleukin-6 and tumor necrosis factor-alpha in hepatocellular carcinoma
Authors: Oh Young Ju , Choi Gyu-Seong , Kim Jongman , Rhu Jinsoo
Published: February 2025

Liver transplantation (LT) is an essential treatment for patients with end-stage liver disease (ESLD), including hepatocellular carcinoma (HCC). Post-transplant complications such as venous congestion and tumor recurrence remain challenging, and recent studies suggest that ischemia-reperfusion injury (IRI) and the resulting inflammatory response play a crucial role in these complications. This study was undertaken to investigate the relationship between early post-operative cytokine profiles and the development of venous congestion and tumor recurrence in LT recipients with HCC. 42 HCC patients that underwent living donor liver transplantation (LDLT) were prospectively studied. Data on liver chemistry, venous outflow reconstruction, plasma cytokine levels (IL-6, TNF-α, IL-10, MMP-1, and HGF), and tumor characteristics were collected. Venous congestion volume was assessed using CT scans, and plasma cytokines were measured multiple times post-LDLT. Elevated IL-6 and TNF-α levels were associated with early liver graft regeneration. Patients with ≥ 15% hepatic congestion showed elevated levels of these cytokines. A weak correlation was observed between ischemic events, congestion, and TNF-α levels. HCC recurrence was associated with higher IL-6 levels. IL-6 and TNF-α play a critical role in early graft regeneration. Venous congestion may significantly impact cytokine levels post-transplantation. Monitoring plasma cytokine profiles could be crucial for managing post-LDLT outcomes.
Physicochemical analysis and molecular characterization of heavy metal tolerant bacteria from Buckingham canal, Neelankarai, Chennai
Authors: SUGITHA S , ABIRAMI G.
Published: February 2025

AimThe escalation of toxic heavy metal concentrations in environmental contexts has manifested as a matter of significant concern in recent times, due to the rapid industrialization driven by the demands of a burgeoning population. This study aims to meticulously examine and evaluate the bioremediation capabilities of bacterial strains that exhibit tolerance to heavy metals, which have been isolated from sediment and aqueous samples collected at Buckingham Canal, Neelankarai, Chennai.
Methods and Results The collected samples were subjected to comprehensive analysis regarding physicochemical characteristics and heavy metal quantification, revealing that Zinc displayed the most significant concentration at 190.3 ppm, succeeded by Manganese at 98.8 ppm within the sediment samples. The water samples revealed the concentration of heavy metals sequence Zn>Mn>Pb>Cu>Cr, in contrast, the sediment samples exhibited an order of Zn>Mn>Cu>Cr>Pb. Among the 25 bacterial isolates, BCSS04 and BCSS17 were chosen for subsequent assays due to their demonstrated tolerance to all five heavy metals, achieving maximum tolerance concentrations of 2100 ppm for lead, 1900 ppm for chromium, zinc, and Manganese, and 1300 ppm for copper, respectively. Genetic amplification indicated that the zntA, pcoA, pbrA, and chrA genes yielded fragment lengths of 2374 bp, 1791 bp, 2396 bp, and 520 bp, respectively. Notably, isolate BCSS17 displayed amplification for both pbrA and zntA genes, while isolate BCSS04 exhibited amplification solely for pbrA gene, lacking amplification for any other heavy metal resistance genes. The results from the BLAST analysis identified isolate BCSS04 as Proteus mirabilis with a 99.31% identity, whereas isolate BCSS17 as Bacillus paramycoides, presenting a 99.85% identity and 99% query coverage.
ConclusionThe study highlights the significant presence of heavy metals in the Buckingham Canal, with zinc being the most abundant. Two bacterial strains, Proteus mirabilis and Bacillus paramycoides, demonstrated high metal tolerance, with BCSS17 exhibiting resistance genes for both lead and zinc. These findings suggest their potential application in bioremediation efforts for heavy metal-contaminated environments
Significance and impact of the study Ultimately, the bacterial species identified in the present investigation represent promising candidates for bioremediation and further exploration in endeavors aimed at the bioremediation of heavy metals within contaminated locations.
Genome-wide identification and characterization of the WRKY gene family in lentil (Lens culinaris Medikus)
Authors: Jirli Shivadarshan S , Madival Sharanbasappa D , Mishra Dwijesh Chandra , Singh Amit kr , Chaturvedi Krishna Kumar , Sinha Shruti , Lal Shashi Bhushan , Mallik Snehasis , Grover Monendra
Published: February 2025

The WRKY gene family plays a very important role in plant growth, development, and response to both biotic and abiotic stresses. Despite its importance, WRKY gene family is yet to be explored in lentil (Lentil culinaris Medikus), an important legume cultivated worldwide. This study presents the first in-depth analysis of WRKY genes in lentil with respect to their genomic organization, evolution, and expression patterns. A total of 105 LcWRKY genes were identified, distributed across seven chromosomes, and classified into six subgroups based on conserved motifs and phylogenetic relationships. Promoter analysis revealed cis-regulatory elements associated with hormone signalling and stress responses underscoring the role of LcWRKY genes in stress adaptation. Chromosome mapping showed uneven LcWRKY gene distribution, with chromosome 5 hosting the most, indicating gene duplication's events might have played role in their evolution. Synteny analysis with Arabidopsis further confirmed the evolutionary conservation of this gene family. In silico gene expression profiling revealed 16 LcWRKY genes that were significantly upregulated under both salt and drought stress conditions, supporting their involvement in stress tolerance. Notably, LcWRKY46 and LcWRKY73 showed significant upregulation in response to salt stress, whereas LcWRKY22 and LcWRKY47 were significantly upregulated under drought conditions, indicating their critical roles in enhancing stress tolerance in lentil. This study not only advances our understanding of the organization and evolution of the LcWRKY gene family but also provides insights into its potential role in stress adaptation, which can be utilized by lentil researchers to design stress-tolerant varieties.
Integrated transcriptome analysis and combinatorial machine learning to construct a homeostatic model of acetylation for ccRCC and validate the key gene GCNT4
Authors: Zhu Baohua , Mo Ziyang , Bao Yi , Gan Xinxin , Wang Linhui
Published: February 2025

Background
Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors of the urinary system. Protein acetylation plays a key role in regulating cellular processes and cancer signaling pathways. This study explores the potential biological mechanisms of ccRCC from the perspective of acetylation.
Methods
This study obtained RNA-seq data and clinical information of ccRCC from TCGA and ICGC, and single-cell RNA sequencing datasets from the GEO database. Ten machine learning algorithms and their 101 combinations were used to analyze the prognostic significance of acetylation-related differentially expressed genes (DEGs) and to construct a prognostic risk model. GSEA was used to analyze the enrichment of different signaling pathways in high-risk and low-risk groups, and the correlation between immune infiltration and risk scores was assessed. Finally, the function of the key gene GCNT4 was verified through cell experiments.
Results
This study identified 84 acetylation-regulated key genes with significant expression differences between tumor and normal tissues, closely linked to patient prognosis. The LASSO + RSF combination model performed best, and the model could accurately predict patient prognosis. The survival of patients in the high-risk group was significantly worse than that in the low-risk group. High expression of GCNT4 was associated with better survival prognosis and was expressed at higher levels in normal tissues than tumor tissues. Overexpression of GCNT4 significantly inhibited the proliferation, invasion, and migration of renal cancer cells and may affect acetylation by regulating the levels of O-GlcNAc modification in cells.
Conclusion
This study constructed a ccRCC acetylation homeostasis model via transcriptome analysis and machine learning, validating GCNT4 as a key gene. High expression of GCNT4 is associated with better survival prognosis and affects acetylation by regulating O-GlcNAc modification levels, inhibiting the proliferation and migration of renal cancer cells, providing a new potential target for the treatment of ccRCC.
Metastatic pattern with mild prognostic impact in high-volume castration-sensitive prostate cancer
Authors: Koguchi Dai , Tsumura Hideyasu , Tabata Ken-ichi , Hirano Shuhei , Shimura Soichiro , Satoh Takefumi , Ikeda Masaomi , Ishii Daisuke , Matsumoto Kazumasa
Published: February 2025

We aimed to investigate the prognostic impact of the extent of bone metastasis (BM) and lung metastasis (LM) in patients with high-volume (HV) castration-sensitive prostate cancer (CSPC). We retrospectively reviewed 379 patients with synchronous metastatic CSPC, focusing on BM patterns, with and without LM. According to the CHAARTED criteria, 115 and 264 patients were respectively classified as having low-volume (LV) disease with BM of extent of disease 1 (LV-EOD1) and HV disease with BM of EOD 1 to 4 (HV-EOD1-4; 197 with BM alone and 67 with BM plus LM). We compared overall survival (OS) between the LV-EOD1 and HV-EOD1-4 groups after propensity score matching (PSM). We used multivariate Cox regression analysis to assess the risk factors for OS in HV-EOD1-4 patients. There was no significant difference in the OS between LV-EOD1 group and HV-EOD ≤ 2 group (in patients with BM alone or after adding patients with BM plus LM) after PSM. A multivariate analysis for OS in HV-EOD1-4, including LM, demonstrated that EOD ≥ 3 and Gleason score ≥ 9 were independent risk factors, and LM had no significant role. Therefore, HV-EOD ≤ 2, regardless of LM, has a prognostic impact comparable to that of LV-EOD1.
Epidemiological burden and trends of neonatal and under-five mortality from lower respiratory infections associated with PM2.5 pollutions in India: A systematic analysis of the Global Burden of Disease Study (1990-2021)
Authors: Roy Chandan
Published: February 2025

Background
Lower respiratory infections (LRIs) caused by PM2.5 pollution are a major factor in neonatal and under-five mortality across India. Therefore, this study explores the linkage between PM2.5 pollution on neonatal and under-five mortality from LRIs.
Materials and Methods
This study utilized ambient PM2.5 geographic mean estimates from Washington University and a household air pollution dataset from the fifth round of the National Family Health Survey (NFHS-5). Furthermore, child mortality data were extracted from the Global Burden of Disease 2021 to assess the impact of PM2.5 on child mortality attributable from LRIs in India. The study employed 'Getis-Ord-Gi*' statistics in ArcMap 10.4 to identify PM2.5 hotspots and cold spots. Temporal trends for neonatal and under-five mortality were analyzed using joinpoint regression analysis, and risk factors of LRIs were visualized through a heat map using MS Excel.
Results
From 1990 to 2021, the neonatal mortality rate (NMR) per 100,000 live births declined significantly by 66%, from 6,989.96 in 1990 to 2,377.36 in 2021. Similarly, the under-five mortality rate (U5MR) per 100,000 live births declined by 74%, from 358.52 to 94.15 per 100,000 live births. Additionally, from 2019 to 2021, a notable decline in mortality was observed for both sexes (NMR: -11.56%; U5MR: -16.21%). However, states such as Rajasthan, Haryana, Uttar Pradesh, and Bihar had notably experienced elevated PM2.5 concentrations, which were likely contributing factors to the higher burden of neonatal and under-five mortality. Additionally, HAP was a major contributor to PM2.5 concentrations in the Indo-Gangetic Plain region (IGP), largely due to the limited usage of clean fuels.
Conclusion
The study revealed that elevated PM2.5 concentrations are likely linked to contributing factors for higher child mortality, particularly in the IGP region. To address this issue, the study suggests increasing public awareness and implementing targeted policies to reduce neonatal and under-five mortality across India.
Impact of metritis and systemic antibiotic treatment on the biochemistry and morphology of the bovine uterus at one month postpartum
Authors: Caldeira Monica O. , Moraes Joao G. N. , Nguyen Thao T. , Silva Josiane C. C. , Ramos Isabella Sellmer , Poock Scott E. , Spencer Thomas. E. , Lucy Matthew C.
Published: February 2025

We explored the biochemistry and morphology of the uterus at approximately one month postpartum for cows that were diagnosed with metritis (uterine disease; n=18) or healthy (n=17) at 7 to 10 d postpartum and either treated or untreated with ceftiofur hydrochloride (2x2 factorial). Cows were slaughtered at one month postpartum and the uterine horn was flushed to identify cows with a purulent or clear (non-purulent) content. RNA was isolated from caruncular (CAR) and inter-caruncular (ICAR) endometrium for RNA sequencing. Light microscopy was used to quantify inflammation and scanning electron microscopy (SEM) was used to assess the closure of the luminal surface of the uterus and the morphology of uterine glands. Results were that postpartum antibiotic treatment did not affect the endpoints that we measured including gene expression and morphology of the uterus. The primary biological driver of uterine function and morphology was inflammation at one month postpartum (endometritis; purulent material in the uterine lumen). Inflammation decreased epithelial growth factor signaling pathway expression (Wnt, Hippo, and Hedgehog) and biological processes involved in the formation of ciliated cells. Based on morphology, epithelial cells closed open areas of a denuded uterine surface using a process that involved depolarization and cell movement (planar cell polarity). Non-canonical Wnt signaling drives planar cell polarity and the loss of Wnt signaling may explain the slower tissue repair in cows with endometritis. Future studies and therapeutic treatments should consider uterine involution as a process of wound repair and tissue regeneration in the face of bacterial infection.
Effectiveness of the fraud triangle model in the detection of financial statement fraud in South African municipalities
Authors: Tshikovhi Ambani , K. Oseifuah Emmanuel , Reynolds Arthur
Published: February 2025

There is a high prevalence of financial statement fraud and wasteful expenditure in South African municipalities. According to the fraud triangle model, pressure, opportunity, and rationalization are the underlying causes of financial statement fraud. The study aimed to examine the effectiveness of the fraud triangle model in detecting financial statement fraud in South African municipalities. The study developed variables serving proxy measures for pressure, opportunity, and rationalization. The variables were analyzed and tested using the logistics regression model and publicly available financial data for the 257 municipalities in South Africa over six years, from 2015/16 to 2020/21. The results showed a high correlation between fraud in financial statements and four fraud risk markers. High capital expenditure, high accrual amounts, poor liquidity ratios, and high leverage ratios are the risk elements. The results contribute fresh perspectives to the corpus of information already available on financial statement fraud in South Africa. To ascertain the effectiveness of the fraud triangle model in identifying and preventing financial statement fraud, future studies should incorporate different range of variables, techniques, and sample sizes.
Professional advancement of women to leadership roles in Moroccan sports federations
Authors: Lotfy Chaymaa , Bennis Bennani Yasmina , Cornet Annie
Published: February 2025

This study explores the dynamics of career anchors shaped by organizational, individual, and societal determinants in relation to women’s access to leadership positions in Moroccan sports federations. In a historically male-dominated setting, understanding these dynamics is essential for promoting more equitable and sustainable career progression. Between January and June 2024, semi-structured interviews were conducted with 28 female leaders from 12 federations, employing a qualitative interpretive approach and thematic analysis using NVivo 14. The findings highlight two anchors specific to the Moroccan socio-cultural context (family and social support and religious and cultural beliefs), which reveal the impact of cultural pressures and familial responsibilities that may hinder women’s advancement. Additionally, six other career anchors prevail in sports: emotional and professional security, managerial competencies, resilient challenge, technical skills, transformative commitment, and global outlook. The interplay of individual, organizational, and societal factors, along with these career anchors, shows that older women seek to make a lasting impact, while younger women prioritize challenges. Family and cultural support helps balance personal life and ambitions, while the development of managerial skills and a supportive work environment proves crucial. Moreover, the economic context, religious beliefs, cultural norms, and international legal frameworks heavily influence women’s career choices, prompting them to pursue stability, ethical alignment, and global opportunities. This study provides decision-makers with a clear understanding of the factors shaping women’s career trajectories and suggests tangible actions (fostering inclusive governance, advancing gender equality, and shifting mindsets) that can enhance the overall performance of the Moroccan sports sector.
Computational Modeling and Biological Evaluation of Benzophenone Derivatives as Antileishmanial Agents
Authors: F. Farias Bárbara , S. Ferreira Miller , O. Miranda Daniel , R. Nunes Tayná , F. Pereira Natália , F. Espuri Patrícia , P. Januario Jaqueline , A. Colombo Fábio , J. Marques Marcos , L. B. Zanin João , G. Soares Marisi , B. de Souza Thiago , T. Carvalho Diogo , A. Chagas-Paula Daniela , F. Dias Danielle
Published: February 2025

Leishmaniasis is a neglected tropical disease with limited therapeutic options characterized
by high toxicity, adverse side effects, and growing resistance to existing treatments. In this study,
machine learning (ML) methods were employed to design and evaluate benzophenone and
xanthone derivatives as potential antileishmanial agents. A dataset of 73 compounds was curated,
and Quantitative Structure-Activity Relationship (QSAR) models were developed using artificial
neural networks (ANN), Random Forest (RF), and J48 decision tree classifiers. The ANN model
achieved the highest accuracy (86.2%) in predicting antileishmanial activity, validated through
in vitro assays. Among 14 newly synthesized benzophenones, compounds 5 and 7 demonstrated
significant biological activity with inhibitory concentration 50 (IC50) values of 10.19 and 14.35 μM,
respectively, and favorable selectivity indices compared to reference drugs pentamidine and
amphotericin B. Structural analysis highlighted the importance of thiosemicarbazone and 4-methyl
groups, alongside electronegative substituents at position 11, in enhancing activity. This study
underscores the potential of computational tools to streamline the discovery of novel, effective,
and selective antileishmanial agents.
Fiber supplements from agro-industrial waste: Effect on valproic acid hepatotoxicity in rats
Authors: Ramirez Maria Rosana , Manuale Debora , Yori Juan C.
Published: February 2025

The agro-industrial sector is one of the biggest organic waste producers. Instead of being discarded into the environment, fruit and vegetable waste could be processed to obtain added value. This article introduces pomace fiber powder made from agroindustrial waste of fruits and vegetables. Its protective potential against hepatotoxicity induced by valproic acid was studied in Wistar rats, both as preventive and curative treatments.
In the preventive test, valproic acid (250 mg/kg/day) was administered orally together with the pomace fiber powder (0.3 and 0.15 mg/kg/day) for 14 days. In the curative test, the rats received valproic acid for 14 days, followed by pomace fiber powder another 14 days, at the same amounts. Physicochemical analysis revealed that the experimental pomace fiber powder contained 15.2 ± 0.5% and 22.0 ± 1.2% of insoluble and soluble dietary fiber, respectively. This ratio made it possible to classify the new supplement as functional. The rats administered with valproic acid gained body weight and demonstrated a significant increase in serum enzyme activities, alanine aminotransferase, and alkaline phosphatase (p < 0.05).
These results were confirmed by histopathological examination. In both preventive and curative treatments, the supplementation normalized body weight, improved liver biomarkers, and attenuated the hepatic injury induced in rats by valproic acid. The new pomace fiber powder made of agro-industrial waste proved to be an effective raw material that attenuates the side effects associated with prolonged valproic acid administration.
Gender inequality in water supply management in rural communities in Brazil
Authors: Machado Anna Virginia Muniz , Oliveira Pedro A. D. , Lima Alyta K. C. , Werneck Brendha , Dias Juliana , Siqueira Natália Lascas
Published: February 2025

This study examines how gender roles and regional factors influence water resource management in rural Brazilian communities. Despite differing environmental conditions, Ceará and Espírito Santo regions share community-managed water systems with state involvement. The research highlights how these factors affect women's participation in water management, revealing significant gender disparities. In Ceará, with its hot and semi-arid climate, women struggle with the dual demands of unpaid domestic labor and community responsibilities, limiting their involvement in water management. In contrast, women in Espírito Santo, a region with a subtropical climate and more rainfall, have a stronger presence in water committees but show less interest in broader community associations. The study identifies patriarchal norms and the lack of recognition of women's contributions as key barriers to their participation. The findings suggest that despite regional differences, gender inequalities are a common challenge. Women are often marginalized, facing skepticism and a lack of trust, which hampers their role in decision-making. The study advocates for strategies at both the legislative and social levels to address these disparities, including gender-focused education and integrating women's needs into water management policies. Promoting women's involvement is crucial for equitable resource distribution and enhancing the resilience of rural communities.
Effectiveness of multi-soil-layering systems in the treatment of sodium chloride-contaminated wastewater
Authors: Ho Chia-Chun , Yang Po-Yen
Published: February 2025

Multi-soil-layering (MSL) is a sustainable wastewater treatment method that uses natural materials. Taiwan has successfully employed MSL to treat rural domestic sewage for reuse and to improve the water quality. However, coastal and riverside areas in Taiwan face challenges with sodium chloride contamination due to seawater intrusion, making conventional purification methods less effective. This study examined the effectiveness of MSL in treating sodium chloride-contaminated wastewater using three experimental tanks. Results showed that when sodium chloride concentration exceeded 2%, the reduction rates for ammonia nitrogen (NH4+-N) and chemical oxygen demand (COD) dropped below 50% from 90%. However, phosphate (PO43−) and nitrate nitrogen (NO3−) reduction rates were less affected. Replacing gravel with zeolite in the MSL system's permeable layers increased sodium chloride tolerance from 2 to 3%, improving NH4+-N reduction to 50% but only slightly affecting COD reduction. Furthermore, low concentration (0.5%) sodium chloride solution to condition the MSL system, fostering the growth of salt-tolerant bacteria (halophiles). Subsequently, at a 50% pollution reduction rate, experiments showed that the tolerance of NH4+-N increased from 2 to 3%, and the sodium chloride tolerance for COD reduction improved from 2.5 to 3.8%. This significantly enhances the applicability of MSL in treating sodium chloride-containing wastewater.
APPROXIMATE LEAST SQUARES ESTIMATION OF ONE FORM OF NON-ELEMENTARY MODULAR LINEAR REGRESSIONS
Authors:   Irkutsk State Transport University, P. Bazilevskiy Mikhail
Published: February 2025

Background. The problem of finding new structural specifications of regression models with interesting interpretive properties is currently relevant. The purpose of the study is to formalize a new structural specification,based on a symbiosis of previously proposed non-elementary and modular linear regressions, to develop an algorithm for its approximate estimation using the ordinary least squares method and to demonstrate its effectiveness using the example of modeling the consumer price index in the Altai Republic. Materials and methods. To estimate the regression models, the ordinary least squares method was used in combination with the «all possible regressions» method. Results. A new structural specification of regression models is formulated – non-elementary modular linear regression, which generalizes many well-known models. An algorithm for its approximate estimation is proposed. The non-elementary modular linear regression constructed using it turned out to be 39.3 % better in terms of the approximation quality of non-elementary regression without modules, and 63.7 % better than linear regression. Conclusions. Using the proposed models of non-elementary modular linear regression, one can successfully solve forecasting problems, as well as the problem of identifying new knowledge about the object of study.
AGREGATION OF QUALITATIVE PRIORITY INDICATORS IN IT PROJECT MANAGEMENT
Authors:   Russian State Social University, A. Sapogov Aleksandr
Published: February 2025

Background. The need to reasonably determine the priority of processing and resolving a number of streaming requests, user requests, client groups within the framework of complex IT projects, such as service, maintenance of IT infrastructure, including the implementation of streaming iterations, predetermines the need to develop new methods based on the use of aggregated indicators of a number of data. The use of previous methods, including methods of queuing theory, is often irrational or occurs in parallel due to the specifics of the task, the characteristics of iterations, changes in the structure of receipt and processing of service requests, territorial division, automation, informatization and the need to process large streaming data. Materials and methods. A methodological approach to neural network parametric aggregation was used as an aggregation technique. Results. This article proposes an approach to determining management priorities for processing and resolving streaming requests within IT projects based on the aggregation of a number of quality indicators. As part of the work, multi-vector quality characteristics were established that reflect the state of the process of accepting a service request for processing, presenting them in the form of vectors of values with criterion indicators. An aggregated information and analytical indicator of the priority of a single service request was calculated. Conclusions. The indicator of the priority of a single service call, obtained using the neural network parametric aggregation model, correlates with the set of initial data and adequately and generally reflects the totality of initial indicators. In addition, this model makes it possible to predict changes when the qualitative parameters included in the calculation shift.
THE METHOD OF MIXED ESTIMATION OF REGRESSION MODEL PARAMETERS WITH AN ARBITRARY COMPOSITION OF OBSERVATION GROUPS
Authors:   Irkutsk State Transport University, I. Noskov Sergey , S. Popov Egor ,   Irkutsk State Transport University
Published: February 2025

Background. The construction of regression models of various complex objects in accordance with the objectives of the study is sometimes accompanied by the need to split the original data sample into subsamples (groups of observations) or the use of the so-called panel data. The purpose of the study is to modify the method for calculating estimates of the parameters of a linear regression equation developed earlier by one of the authors, using the mixed estimation method. Materials and methods. To achieve this goal, the mathematical apparatus for solving linear and linear Boolean programming problems was used. Results. This goal is formalized by setting the task of automating the formation of the composition of the index set of observation numbers to implement the antirobust estimation method within the framework of the mixed estimation method by solving a linear Boolean programming problem. Conclusions. The approach described in the work allows us to combine the advantages of the least modulus and anti-robust estimation methods when modeling. A regression model of freight turnover of road transport in the Russian Federation has been constructed that is adequate to the analyzed object.
Great Rivers of the BRICS Countries: Status and Problems
Authors:   Institute of Ecology of the Volga River Basin of the RAS – Branch of the Samara Federal Research Center of the RAS, S. Rozenberg Gennady , V. Kostina Natalia ,   Institute of Ecology of the Volga River Basin of the RAS – Branch of the Samara Federal Research Center of the RAS, E. Kudinova Galina ,   Institute of Ecology of the Volga River Basin of the RAS – Branch of the Samara Federal Research Center of the RAS, G. Rozenberg Anastasia ,   Institute of Ecology of the Volga River Basin of the RAS – Branch of the Samara Federal Research Center of the RAS
Published: February 2025

Background. Clean fresh water is a renewable resource, the value of which is con stantly increasing. The possibility of cooperation between the BRICS countries in solving water and environmental problems of the great river basins – the Amazon, Volga, Ganges, Yangtze and Orange – is considered. Materials and methods. They are compared by a number of geographical parameters (length, basin area, volume of water resources, etc.). It is shown that these rivers are similar to varying degrees in many parameters of anthropogenic impact(pollution, regulation, uncontrolled use, urbanization, etc.). The BRICS countries exceed the G7 countries in fresh water reserves by more than 2.3 times; In terms of fresh water con sumption per capita, the G7 countries are 10 times higher than the BRICS countries. Results and conclusions. Using the Volga and Yangtze as examples, a methodology for comparing the socio-ecological-economic systems of the basins is proposed. A conclusion is made about the need for such a comparison of the great rivers of the BRICS.
A Double-blind Randomized Split-mouth Clinical Trial on a Hemostatic Dental Material Containing Aloe Vera Nanoparticles: The Effects on Pain
and Occurrence of Dry Socket after Tooth Extraction
Authors: Vazirabadi Samin Baghban , Mehrpouya Mahsa , Motallebi Naiemeh , Hosseini Olduz , Khosroshahi Ali Zaheri , Sharifi Simin , Dizaj Solmaz Maleki , Ghavimi Mohammad Ali
Published: February 2025

Introduction:

Pain, infection, and dry socket are the primary complications following
tooth extraction. Hence, the aim of this study was to evaluate the pain range and incidence of
dry socket after using a hemostatic spongy material containing aloe vera nanoparticles after
split-mouth extraction of the mandibular first and second molars, compared to a control sponge
without aloe vera nanoparticles in patients referred to the Tabriz Faculty of Dentistry.

Materials and Methods:

This double-blind, split-mouth clinical study was conducted on 30 patients
referred to the Faculty of Dentistry in Tabriz. Patients were selected according to specific
inclusion and exclusion criteria and required extraction of two teeth. After tooth extraction, an
aloe vera nanoparticle-containing hemostatic sponge was randomly placed in one extraction site,
while a sponge without aloe vera nanoparticles served as the control in the other extraction site.
Pain levels were measured at 12, 24, 48, and 72 h after extraction using a Visual Analog Scale
(VAS), where patients marked their pain level from 1 (lowest pain) to 10 (highest pain) at each
time point. Patients received a form to record the required information and instructions on how
to do so, which they submitted upon completion. To assess the occurrence of dry socket, patients
were asked to come four days after extraction. Data were analyzed using SPSS software with
relevant statistical tests, considering a significance level of P<0.05.

Results:

In both groups, the average pain levels decreased significantly over 72 h (P=0.001 and
P=0.01 for the test and control groups, respectively). Additionally, for 48 h and 72 h time points,
the test group showed better pain control results than the control group (P=0.04 and P=0.04 for
48 h and 72 h, respectively). No cases of dry sockets were found in either group.

Conclusion:

The aloe vera-containing sponge demonstrated better performance in pain control
following tooth extraction compared to the control group. For dry socket occurrence, both
sponges showed similar results.
Efficacy of Dapagliflozin and Telmisartan Combination Therapy in Reducing Albuminuria and Inflammatory Markers in Diabetic Nephropathy: A Prospective Observational Study
Authors: Chauhan Shalu , Bhandari Uma , Habib Anwar
Published: February 2025

Background:

Diabetic nephropathy, a major contributor to chronic kidney disease, is
closely associated with inflammatory responses.

Objective:

This study aimed to evaluate the effectiveness of combination therapy with dapagliflozin
and telmisartan in treating diabetic nephropathy and its effect on patient’s albuminuria levels.

Material and Methods:

We conducted a 12-week prospective observational study to assess diabetic
nephropathy. Patients with diabetic nephropathy were treated with either dapagliflozin and telmisartan
(n=92) or telmisartan alone (n=92). Measurements of waist-to-hip ratio, fasting blood glucose,
hemoglobin A1c (HbA1c), blood pressure, urinary albumin-to-creatinine ratio (UACR), estimated
glomerular filtration rate (eGFR), uric acid, blood urea nitrogen, lipid profile, and inflammatory biomarkers,
including C-C motif chemokine ligand 21 messenger RNA (CCL21 mRNA) and monocyte
chemoattractant protein-1 (MCP-1), were obtained at baseline and following 12-weeks of treatment.

Results:

Dapagliflozin and telmisartan combination therapy demonstrated a significant decrease in
UACR compared with baseline levels (p<0.001). After treatment, the dapagliflozin and telmisartan
group had significantly lower waist-to-hip ratio, fasting blood glucose, HbA1c, uric acid, total cholesterol,
and low-density lipoprotein compared with the monotherapy group (p<0.05). Additionally,
inflammatory biomarkers, including CCL21 mRNA and MCP-1, were substantially lower in the
combination therapy group than in the monotherapy group (p<0.05).

Conclusion:

In comparison to monotherapy, combination therapy demonstrated more significant
clinical effects in treating diabetic nephropathy. This combination therapy effectively controls blood
glucose levels and UACR, reduces inflammatory responses, and improves kidney function recovery
in diabetic nephropathy patients, thereby enhancing the overall clinical treatment outcomes for these
patients.
The Role of E-Learning Crack-Up Perception and Fear of Academic Year Loss in Students’ Psychological Distress and Academic Performance
Authors: Abdelwahed Nadia A. Abdelmegeed , Ramish Muhammad Sufyan
Published: February 2025

This study examines the effect of e-learning crack-up perception (ECUP) and fear of academic year loss (FAYL) on psychological distress (PD). The study also explores the impact of PD on students' academic performance (AP). It uses a quantitative method based on data collected from Egyptian medical university students using convenience sampling. The study utilized 313 cases to get the final results. Using path analysis through analysis of moment structures (AMOS) software, the study confirmed a positive effect of ECUP on FAYL (β = 0.061; CR = 3.069; p < 0.01) and PD (β = 0.098; CR = 2.840; p < 0.01). Moreover, the study confirmed a positive effect of FAYL on PD (β = 0.181; CR = 3.910; p < 0.01), and the path analysis demonstrates a negative impact of PD on AP (β = -0.008; CR = 0.348; p > 0.01). The study's findings assist policymakers and university authorities in reducing PD among medical students by reducing burden and pressure, reducing fear of failure, and diminishing the problems that exist during the online or e-learning process. AP should be enhanced by getting rid of PD, anxiety and stress among students, particularly that which results from and is produced during the use of e-learning and online systems. Finally, the findings of the study contribute to the literature of psychology, management, business, and medical science, specifically in terms of students' AP, PD, and mental problems.
The Sworn Promise of Zaisang Tsyuryum Nushaev for Fidelity to Service in the Position of Guardian of Erketenevsky Ulus, given by him on April 12, 1855
Authors:   Kalmyk Scientific Center of the RAS, Mandzhikova Larisa B.
Published: February 2025

Introduction. This article continues author’s study of the species composition and content of archival documents created during the activity of the Horde branch of the Astrakhan Chamber of State Property (1848–1881). Of particular interest are the cases revealing the process of infusion of Kalmyk society into the all—Russian state system after the adoption of the “Regulations on the Administration of the Kalmyk people” dated April 23, 1847. The purpose of the study is to introduce scientific turnover is the oath promise of Zaisang Tsyuryum Nushaev, to study the procedure for reviewing documents on the appointment of a guardian over the ulus, to identify common features and peculiarities in the acceptance of an oath (oath) by Kalmyk owners in accordance with all-Russian norms. Results. The analysis of archival documents and the procedure for their review revealed their compliance with all-Russian requirements and such a feature in office management as bilingualism — the preparation of documents in Russian and Kalmyk using the Old Kalmyk script todo bichig (“clear writing”). It was found out that the procedure for making an oath as a type of document in the Kalmyk steppe in the 19th century corresponded to all-Russian norms, but at the same time had differences in the swearing-in ceremony and its written design.
Materials of the Newspaper “Astrakhanskiy Listok” in 1913 as Sources on the Reform of the Judicial System in the Kalmyk Steppe and the Inner Kyrgyz Horde at the Beginning of the 20th Century
Authors:   Kalmyk Scientific Center of the RAS, Gunaev Evgeniy A.
Published: February 2025

Introduction. This article presents the texts and characteristics of two publications in the newspaper “Astrakhanskiy Listok” for 1913, devoted to the reforms of the judicial system in the Kalmyk steppe and the Inner Kyrgyz Horde at the beginning of the 20th century. The purpose of the article is to introduce these publications into scientific circulation, to study them from the point of view of content and historical context. Results. The main provisions of the projects of reforming the judicial system of the two named national suburbs are given: the initial one from the Ministry of Internal Affairs, the second one — jointly with the Ministry of Justice of the Russian Empire. The biographical information of the editor and publisher of the newspaper “Astrakhanskiy Listok” V. I. Sklabinsky is given. The texts of the articles “Judicial reforms in the Kalmyk and Kyrgyz Steppe” and “Restoration of the Archaic Role of the Ulus Zargo. (On the Issue of Kalmyk Justice”, as well as comments on them. Conclusions. These publications substantiate and note the delay in reforming the justice system in the Kalmyk Steppe and the Inner Kyrgyz Horde in comparison with modern trends of that time; the implementation of justice by quasi-judicial bodies; the application of pre-reform procedural laws; the lack of proper legal training among the personnel of the courts. The urgency of the early introduction of a modern court and judicial procedure is expressed. At the same time, the provisions of the official drafts on the impossibility of introducing a jury trial in the Kalmyk steppe and the Inner Kyrgyz Horde are supported, which is associated with poor knowledge of the Russian language, lack of land qualifications, and a number of other exceptions due to both the shortcomings of the existing judicial system and the peculiarities of the way of life of nomadic foreigners.
New Written Novel’s Architectonics: the Narrative’s Features and Evolutionary Status of the Dilogy “Aisanat” by A. Urusova
Authors:   Institute of Humanitarian Researches — branch of Kabardino-Balkarian Scientific Center of the RAS, Uzdenova Fatima T. , Tolgurov Takhir Z. ,   Kabardino-Balkarian Scientific Center of the RAS
Published: February 2025

Introduction. The structural and substantive components of the novel and its transformations are analyzed in the article. Research methods: historical-typological, structural-descriptive, comparative-contrastive, narrative, biographical, hermeneutic. Results. The formation of a new matrix of the cultural state in the first decades of the Soviet reality determined a special form of large-format prose, the attributive feature of which can be considered the combination of parameters of utilitarian, ideological and revolutionary-educational texts of the era of the Soviet government’s formation and the sufficiently developed literature’s qualities. The above directly relates to the North Caucasian authors’ works, including the Karachay writer Aminat Urusova (1911–1995). Her novel-dilogy “Aisanat” is an autobiographical work, officially dated to the 60-70s of the 20th century, however, according to a number of signs, it can be argued that the novel’s text was created over a long period of time and one of its parts falls on the pre-war period: the presence of signs of a chronicle novel, which was in trend in the Soviet literature of the 30s of the 20th century, testifies in its favor. Therefore, the author’s work can be attributed as a special typological variety of the new-written Soviet novel, presented mainly in the literature of the peoples who did not have developed writing before 1917 and were subjected to the total deportation during the Stalin’s rule years. The study of the figurative structure’s architectonics, the structural and content components, syntax and speech richness of the language, found in the episodes and final chapters marked by a professional approach, allows us to come to the conclusion about the representative evolutionary shifts of the novel narrative of A. Urusova.
Delineating Surfaces
Authors: Nguyen Thi Phuong-Trâm
Published: February 2025

This paper retraces the explorations engaged in by the Minim friar Jean-François Niceron (1613-1646). His treatise, La Perspective curieuse, recounts his search for anamorphic images and suggests the pursuit of ‘delight in seeing the possibilities beyond the expected’ that these images offer. Anamorphic representations are deformed images, whereby the point of view is displaced in space. As a result, the resolution of the image is only possible through the adjustment of the body, the re-positioning of the body near that unique secondary vantage point. Based on the capacity of anamorphic representations to disclose a space for wonder manifested only in the physical encounter with the image, the following text presents a workshop undertaken with PhD students where we re-enacted Niceron’s drawing instructions to explore the significance of ‘reaching toward a meaning not yet known’ that he envisioned.
Through the workshop, the act of delineating a surface became a way to occupy and inhabit the space. The text is presented in the format of a script to allow readers to follow the events that happened during the workshop, but also to encourage rehearsal and to invite the event to be played again. The script, as well as Niceron’s drawing instructions, are meant to be read, played and repeated, in the same way the movement by a body is a prerequisite for uncovering the meaning of the anamorphic image. These re-enactments do not only possess the potential to bring the past into the present, but they also—by the act of imagining a past-in- the-present—project our understanding of history into possible futures.
Read the full article online at: https://drawingon.org/Issue-02-07-Delineating-Surfaces