bluuebunny/crossref_metadata_2025 huggingface dataset:
Nationwide differences in cytology fixation and processing methods and their impact on interlaboratory variation in PD-L1 positivity
Authors: Koomen Bregje M. , de Boer Mirthe , van Dooijeweert Carmen , van Lindert Anne S. R. , Deckers Ivette A. G. , Voorham Quirinus J. M. , Willems Stefan M.
Published: November 2022

Programmed death ligand-1 (PD-L1) immunostaining, which aids clinicians in decision-making on immunotherapy for non-small cell lung cancer (NSCLC) patients, is sometimes performed on cytological specimens. In this study, differences in cytology fixation and cell block (CB) processing between pathology laboratories were assessed, and the influence of these differences on interlaboratory variation in PD-L1 positivity was investigated. Questionnaires on cytology processing were sent to all Dutch laboratories. Information gathered from the responses was added to data on all Dutch NSCLC patients with a mention of PD-L1 testing in their cytopathology report from July 2017 to December 2018, retrieved from PALGA (the nationwide network and registry of histo- and cytopathology in the Netherlands). Case mix-adjusted PD-L1 positivity rates were determined for laboratories with known fixation and CB method. The influence of differences in cytology processing on interlaboratory variation in PD-L1 positivity was assessed by comparing positivity rates adjusted for differences in the variables fixative and CB method with positivity rates not adjusted for differences in these variables. Twenty-eight laboratories responded to the survey and reported 19 different combinations of fixation and CB method. Interlaboratory variation in PD-L1 positivity was assessed in 19 laboratories. Correcting for differences in the fixative and CB method resulted in a reduction (from eight (42.1%) to five (26.3%)) in the number of laboratories that differed significantly from the mean in PD-L1 positivity. Substantial variation in cytology fixation and CB processing methods was observed between Dutch pathology laboratories, which partially explains the existing considerable interlaboratory variation in PD-L1 positivity.
Variable detection of Omicron-BA.1 and -BA.2 by SARS-CoV-2 rapid antigen tests
Authors: Osterman Andreas , Badell Irina , Dächert Christopher , Schneider Nikolas , Kaufmann Anna-Yasemin , Öztan Gamze Naz , Huber Melanie , Späth Patricia M. , Stern Marcel , Autenrieth Hanna , Muenchhoff Maximilian , Graf Alexander , Krebs Stefan , Blum Helmut , Czibere Ludwig , Durner Jürgen , Kaderali Lars , Baldauf Hanna‑Mari , Keppler Oliver T.
Published: November 2022

During 2022, the COVID-19 pandemic has been dominated by the variant of concern (VoC) Omicron (B.1.1.529) and its rapidly emerging subvariants, including Omicron-BA.1 and -BA.2. Rapid antigen tests (RATs) are part of national testing strategies to identify SARS-CoV-2 infections on site in a community setting or to support layman’s diagnostics at home. We and others have recently demonstrated an impaired RAT detection of infections caused by Omicron-BA.1 compared to Delta. Here, we evaluated the performance of five SARS-CoV-2 RATs in a single-centre laboratory study examining a total of 140 SARS-CoV-2 PCR-positive respiratory swab samples, 70 Omicron-BA.1 and 70 Omicron-BA.2, as well as 52 SARS-CoV-2 PCR-negative swabs collected from March 8th until April 10th, 2022. One test did not meet minimal criteria for specificity. In an assessment of the analytical sensitivity in clinical specimen, the 50% limit of detection (LoD50) ranged from 4.2 × 104 to 9.2 × 105 RNA copies subjected to the RAT for Omicron-BA.1 compared to 1.3 × 105 to 1.5 × 106 for Omicron-BA.2. Overall, intra-assay differences for the detection of Omicron-BA.1-containing and Omicron-BA.2-containing samples were non-significant, while a marked overall heterogeneity among the five RATs was observed. To score positive in these point-of-care tests, up to 22-fold (LoD50) or 68-fold (LoD95) higher viral loads were required for the worst performing compared to the best performing RAT. The rates of true-positive test results for these Omicron subvariant-containing samples in the highest viral load category (Ct values < 25) ranged between 44.7 and 91.1%, while they dropped to 8.7 to 22.7% for samples with intermediate Ct values (25–30). In light of recent reports on the emergence of two novel Omicron-BA.2 subvariants, Omicron-BA.2.75 and BJ.1, awareness must be increased for the overall reduced detection rate and marked differences in RAT performance for these Omicron subvariants.
A machine learning approach for cross-domain plant identification using herbarium specimens
Authors: Chulif Sophia , Lee Sue Han , Chang Yang Loong , Chai Kok Chin
Published: November 2022

The preservation of plant specimens in herbaria has been carried out for centuries in efforts to study and confirm plant taxa. With the increasing collection of herbaria made available digitally, it is practical to use herbarium specimens for the automation of plant identification. They are also substantially more accessible and less expensive to obtain compared to field images. In fact, in remote and inaccessible habitats, field images of rare plant species are still immensely lacking. As a result, rare plant species identification is challenging due to the deficiency of training data. To address this problem, we investigate a cross-domain adaptation approach that allows knowledge transfer from a model learned from herbarium specimens to field images. We propose a model called Herbarium–Field Triplet Loss Network (HFTL network) to learn the mapping between herbarium and field domains. Specifically, the model is trained to maximize the embedding distance of different plant species and minimize the embedding distance of the same plant species given herbarium–field pairs. This paper presents the implementation and performance of the HFTL network to assess the herbarium–field similarity of plants. It corresponds to the cross-domain plant identification challenge in PlantCLEF 2020 and PlantCLEF 2021. Despite the lack of field images, our results show that the network can generalize and identify rare species. Our proposed HFTL network achieved a mean reciprocal rank score of 0.108 and 0.158 on the test set related to the species with few training field photographs in PlantCLEF 2020 and PlantCLEF 2021, respectively.
Employing deep learning for sex estimation of adult individuals using 2D images of the humerus
Authors: Venema Javier , Peula David , Irurita Javier , Mesejo Pablo
Published: November 2022

Biological profile estimation, of which sex estimation is a fundamental first stage, is a really important task in forensic human identification. Although there are a large number of methods that address this problem from different bone structures, mainly using the pelvis and the skull, it has been shown that the humerus presents significant sexual dimorphisms that can be used to estimate sex in their absence. However, these methods are often too subjective or costly, and the development of new methods that avoid these problems is one of the priorities in forensic anthropology research. In this respect, the use of artificial intelligence may allow to automate and reduce the subjectivity of biological profile estimation methods. In fact, artificial intelligence has been successfully applied in sex estimation tasks, but most of the previous work focuses on the analysis of the pelvis and the skull. More importantly, the humerus, which can be useful in some situations due to its resistance, has never been used in the development of an automatic sex estimation method. Therefore, this paper addresses the use of machine learning techniques to the task of image classification, focusing on the use of images of the distal epiphysis of the humerus to classify whether it belongs to a male or female individual. To address this, we have used a set of humerus photographs of 417 adult individuals of Mediterranean origin to validate and compare different approaches, using both deep learning and traditional feature extraction techniques. Our best model obtains an accuracy of 91.03% in test, correctly estimating the sex of 92.68% of the males and 89.19% of the females. These results are superior to the ones obtained by the state of the art and by a human expert, who has achieved an accuracy of 83.33% using a state-of-the-art method on the same data. In addition, the visualization of activation maps allows us to confirm not only that the neural network observes the sexual dimorphisms that have been proposed by the forensic anthropology literature, but also that it has been capable of finding a new region of interest.
Mind the gap—the use of sodium fluoresceine for resection of brain metastases to improve the resection rate
Authors: Kerschbaumer Johannes , Demetz Matthias , Krigers Aleksandrs , Pinggera Daniel , Spinello Antonio , Thomé Claudius , Freyschlag Christian F.
Published: November 2022

Introduction and purpose

Brain metastases appear to be well resectable due to dissectable tumor margins, but postoperative MRI quite often depicts residual tumor with potential influence on tumor control and overall survival. Therefore, we introduced sodium fluoresceine into the routine workflow for brain metastasis resection. The aim of this study was to evaluate whether the use of fluorescence-guided surgery has an impact on postoperative tumor volume and local recurrence.

Material and methods

We retrospectively included patients who underwent surgical resection for intracranial metastases of systemic cancer between 11/2017 and 05/2021 at our institution. Tumor volumes were assessed pre- and postoperatively on T1-CE MRI. Clinical and epidemiological data as well as follow-up were gathered from our prospective database.

Results

Seventy-nine patients (33 male, 46 female) were included in this study. Median preoperative tumor volume amounted to 11.7cm3 and fluoresceine was used in 53 patients (67%). Surgeons reported an estimated gross total resection (GTR) in 95% of the cases, while early postoperative MRI could confirm GTR in 72%. Patients resected using fluoresceine demonstrated significantly lower postoperative residual tumor volumes with a difference of 0.7cm3 (p = 0.044) and lower risk of local tumor recurrence (p = 0.033). The use of fluorescence did not influence the overall survival (OS). Postoperative radiotherapy resulted in a significantly longer OS (p = 0.001).

Discussion

While GTR rates may be overrated, the use of intraoperative fluorescence may help neurosurgeons to achieve a more radical resection. Fluoresceine seems to facilitate surgical resection and increase the extent of resection thus reducing the risk for local recurrence.
Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors
Authors: Schmitt Andrea , Falkai Peter , Papiol Sergi
Published: November 2022

Since more than 3 decades, schizophrenia (SZ) has been regarded as a neurodevelopmental disorder. The neurodevelopmental hypothesis proposes that SZ is associated with genetic and environmental risk factors, which influence connectivity in neuronal circuits during vulnerable developmental periods. We carried out a non-systematic review of genetic/environmental factors that increase SZ risk in light of its neurodevelopmental hypothesis. We also reviewed the potential impact of SZ-related environmental and genetic risk factors on grey and white matter pathology and brain function based on magnetic resonance imaging and post-mortem studies. Finally, we reviewed studies that have used patient-derived neuronal models to gain knowledge of the role of genetic and environmental factors in early developmental stages. Taken together, these studies indicate that a variety of environmental factors may interact with genetic risk factors during the pre- or postnatal period and/or during adolescence to induce symptoms of SZ in early adulthood. These risk factors induce disturbances of macro- and microconnectivity in brain regions involving the prefrontal, temporal and parietal cortices and the hippocampus. On the molecular and cellular level, a disturbed synaptic plasticity, loss of oligodendrocytes and impaired myelination have been shown in brain regions of SZ patients. These cellular/histological phenotypes are related to environmental risk factors such as obstetric complications, maternal infections and childhood trauma and genetic risk factors identified in recent genome-wide association studies. SZ-related genetic risk may contribute to active processes interfering with synaptic plasticity in the adult brain. Advances in stem cell technologies are providing promising mechanistic insights into how SZ risk factors impact the developing brain. Further research is needed to understand the timing of the different complex biological processes taking place as a result of the interplay between genetic and environmental factors.
Probability distribution characteristics of summer extreme precipitation in Xinjiang, China during 1970–2021
Authors: Aihaiti Ailiyaer , Wang Yu , Ali Mamtimin , Zhu Lianhua , Liu Junjian , Zhang Hailiang , Gao Jiacheng , Wen Cong , Song Meiqi
Published: November 2022

Based on the daily precipitation data of 96 stations in Xinjiang, China, from 1970 to 2021, the trend of summer extreme precipitation indices and their regional characteristics are analyzed. The generalized extreme value (GEV) model is used to investigate the probability distribution characteristics of summer extreme precipitation indices in northern, southern, and eastern Xinjiang. The results show that (1) The summer maximum 1-day precipitation (RX1day) and maximum 5-day precipitation (RX5day) of most stations in Xinjiang showed an increasing trend, while the summer consecutive dry days (CDD) showed a decreasing trend. (2) The climatology (mean intensity) of RX1day, RX5day, and CDD at most stations in northern Xinjiang were more than 10 mm, more than 15 mm, and less than 25 days, respectively, while those at most stations in southern and eastern Xinjiang were less than 10 mm, less than 15 mm, and more than 25 days. The regional averaged climatology and inter-annual variability of RX1day/RX5day (CDD) in southern and eastern Xinjiang were smaller (larger) than that in northern Xinjiang. (3) The 20-year return level (RL20) of RX1day, RX5day, and CDD at stations in northern Xinjiang were 19.38–56.57 mm, 28.05–70.91 mm, and 22.51–51.05 days, respectively. The RL20 of RX1day, RX5day, and CDD at stations in southern Xinjiang were 21.31–46.07 mm, 23.99–72.89 mm, and 14.94–89.80 days, respectively. The RL20 of RX1day, RX5day, and CDD at stations in eastern Xinjiang were 8.89–36.36 mm, 10.13–50.66 mm, and 26.75–92.00 days, respectively. Compared with northern Xinjiang, there were lesser RX1day and RX5day events, with weaker intensity and smaller variability in southern and eastern Xinjiang. And the CDD events were opposite.
A single-domain spectral solver for spatially nonsmooth differential equations of quasistatic solid mechanics in polar coordinates
Authors: Perchikov Nathan , Diehl Martin
Published: November 2022

In the present work, a spectral solver is developed for integration of certain differential equations of solid mechanics, namely static stress equilibrium in composite materials, described in cylindrical or spherical polar coordinates. The spectral approach is encompassed in approximating the displacement field using expansion into a series of Chebyshev polynomials in the radial coordinate and complex exponents in the angular direction. Consequently, differential operators in real space become algebraic operators in spectral space. The spatial heterogeneity and metric non-flatness pertinent to polar geometry are addressed by an iterative strategy, employing both second-order and first-order iterative solvers. The essence of the new contribution is in addressing the difficulty posed by the inherent nonsmoothness present in composite materials and the polar singularity. The interplay of the two produces instability, which is resolved in the proposed approach, specifically by using a new efficient linesearch algorithm, appropriate for the studied class of problems. The method is illustrated by analysis of 1D and 2D linear-elastic and linear-elastic–perfectly plastic response of composites to prescribed radial surface displacement. The developed method allows performing stress homogenization on polar representative volume elements, which has its conceptual advantages, while allowing similar runtime (for sufficient computing resources and an iterative strategy) to the one exhibited by spectral analysis in Cartesian coordinates.
Aberrant splicing caused by exonic single nucleotide variants positioned 2nd or 3rd to the last nucleotide in the COL4A5 gene
Authors: Okada Eri , Aoto Yuya , Horinouchi Tomoko , Yamamura Tomohiko , Ichikawa Yuta , Tanaka Yu , Ueda Chika , Kitakado Hideaki , Kondo Atsushi , Sakakibara Nana , Suzuki Ryota , Usui Joichi , Yamagata Kunihiro , Iijima Kazumoto , Nozu Kandai
Published: November 2022

Background and objectives

The evident genotype–phenotype correlation shown by the X-linked Alport syndrome warrants the assessment of the impact of identified gene variants on aberrant splicing. We previously reported that single nucleotide variants (SNVs) in the last nucleotide of exons inCOL4A5cause aberrant splicing. It is known that the nucleotides located 2nd and 3rd to the last nucleotides of exons can also play an essential role in the first step of the splicing process. In this study, we aimed to investigate whether SNVs positioned 2nd or 3rd to the last nucleotide of exons inCOL4A5resulted in aberrant splicing.

Methods

We selected eight candidate variants: six from the Human Gene Variant Database Professional and two from our cohort. We performed anin-vitrosplicing assay and reverse transcription-polymerase chain reaction (RT-PCR) for messenger RNA obtained from patients, if available.

Results

The candidate variants were initially classified into the following groups: three nonsense, two missense, and three synonymous variants. Splicing assays and RT-PCR for messenger RNA revealed that six of the eight variants caused aberrant splicing. Four variants, initially classified as non-truncating variants, were found to be truncating ones, which usually show relatively more severe phenotypes.

Conclusion

We revealed that exonic SNVs positioned 2nd or 3rd to the last nucleotide of exons in theCOL4A5were responsible for aberrant splicing. The results of our study suggest that attention should be paid when interpreting the pathogenicity of exonic SNVs near the 5′ splice site.
“Contingent power extension” and regional (dis)integration: China’s Belt and Road Initiative and its consequences for the EU
Authors: Gurol Julia , Rodríguez Fabricio
Published: November 2022

In this article, we explore the Belt and Road Initiative (BRI) as a case of “Contingent Power Extension” (CPE) towards the European Union (EU), assessing its implications for regional (dis)integration in the latter. CPE is a conceptual prism that interprets the BRI as a polymorphous, dynamic, and context-specific mechanism through which Chinese foreign policy elites intend to convey, amplify, and legitimize the regime’s power-reach into other regions, including the EU. Along two examples—the 14 + 1 Cooperation Forum and the Port of Genoa in Italy—we examine the power dynamics of the BRI by tracing (a) the processual impact of power extension towards the EU and (b) the (un)intended consequences for the EU in terms of (dis)integration. The findings of our analysis provide an insight into the multicausal relations between the BRI and European (dis)integration not as a static outcome but rather as a contested process of struggle. The article concludes by discussing whether and how the EU can strengthen its own institutional foundations and use its systemic leverage to respond to the BRI while enhancing regional integration in the process.
Irruptions of Pine Grosbeaks pulled by Rowanberry peaks in southern areas
Authors: Dale Svein
Published: November 2022

Several species of owls and seed-eating birds breeding in boreal forests may occur irruptively in areas south of their regular wintering range. One common explanation is that they may be forced to move south if food supplies have crashed (push hypothesis). Little attention has been devoted to the alternative idea that the birds are drawn towards abundant food further south (pull hypothesis), even if they could overwinter further north. I evaluate these two hypotheses (push or pull) using data on winter irruptions of the Pine Grosbeak (Pinicola enucleator) and one main type of winter food, seeds in berries of Rowan (Sorbus aucuparia). Grosbeak numbers during winter in southern Norway and Sweden usually peaked at 2–3 year intervals during 1959–2020, and Rowanberries in Norway peaked at 2–3 year intervals during 1980–2020. Pine Grosbeak peaks coincided with Rowanberry peaks in most years, and annual number of grosbeaks was positively correlated with the Rowanberry index. However, even in irruption years grosbeaks moved north already in January–February, inconsistent with the push hypothesis. Furthermore, Rowan masting in Norway and Finland usually had synchronous cycles, implying that irruptions were triggered even when Rowans had large crops close to the most likely origin of irruptions, opposite to what is expected by the push hypothesis. Thus, available evidence is most consistent with the pull hypothesis: Pine Grosbeaks move south in winters with high Rowanberry abundance and exploit this resource until it is gone by mid-winter, and then return to northern areas.
A Review of the Compressive Stiffness of the Human Head
Authors: Thompson-Bagshaw Darcy W. , Quarrington Ryan D. , Jones Claire F.
Published: November 2022

Synthetic surrogate head models are used in biomechanical studies to investigate skull, brain, and cervical spine injury. To ensure appropriate biofidelity of these head models, the stiffness is often tuned so that the surrogate’s response approximates the cadaveric response corridor. Impact parameters such as energy, and loading direction and region, can influence injury prediction measures, such as impact force and head acceleration. An improved understanding of how impact parameters affect the head’s structural response is required for designing better surrogate head models. This study comprises a synthesis and review of all existingex vivohead stiffness data, and the primary factors that influence the force–deformation response are discussed. Eighteen studies from 1972 to 2019 were identified. Head stiffness statistically varied with age (pediatric vs. adult), loading region, and rate. The contact area of the impactor likely affects stiffness, whereas the impactor mass likely does not. The head’s response to frontal impacts was widely reported, but few studies have evaluated the response to other impact locations and directions. The findings from this review indicate that further work is required to assess the effect of head constraints, loading region, and impactor geometry, across a range of relevant scenarios.
An ethnographic investigation of medical students’ cultural competence development in clinical placements
Authors: Liu Jia , Li Shuangyu
Published: November 2022

As a result of an increased understanding of culture’s impact on health and healthcare, cultural competence and diversity curricula have been incorporated into many medical programs. However, little is known about how students develop their cultural competence during their training. This ethnographic case study combined participant observation with interviews and focus group to understand students’ views and experiences in developing their cultural competence during clinical placements. The results show that students’ development of cultural competence is an individually varied process via four distinctive yet interrelated learning avenues. Immersion in a diverse healthcare environment contributes to students’ development of cultural awareness and knowledge. Observation of culturally appropriate or inappropriate practices allows students to enhance their practical skills and critical reflection. Interaction with other clinical professionals, patients, and their family members, enables students’ engagement within the busy clinical practice. Reflection helps students to actively think about culture’s impact on health and internalize the importance of cultural competence. Students’ learning via each avenue is interrelated and constantly interacting with their learning environment, which collectively contributes to their development. Integrating the results allowed the authors to generate a theoretical model that conceptualizes medical students’ cultural competence development in clinical placements, which unearths students’ cultural learning within the informal and hidden curriculum. This study provides a rare view of students’ development of cultural competence in clinical placements, which may inform the pedagogic development of cultural competence and diversity education in medicine and healthcare.
Initiating Cognitive Processing Therapy (CPT) in Community Settings: A Qualitative Investigation of Therapist Decision-Making
Authors: Thomas Fiona C. , Loskot Taylor , Mutschler Christina , Burdo Jessica , Lagdamen Jansey , Sijercic Iris , Lane Jeanine E. M. , Liebman Rachel E. , Finley Erin P. , Monson Candice M. , Wiltsey-Stirman Shannon
Published: November 2022

Various organizations have provided treatment guidelines intended to aid therapists in deciding how to treat posttraumatic stress disorder (PTSD). Yet evidence-based psychotherapies (EBPs) for PTSD in the community may be difficult to obtain. Although strides have been made to implement EBPs for PTSD in institutional settings such as the United States Veterans Affairs, community uptake remains low. Factors surrounding clients’ decisions to enroll in EBPs have been identified in some settings; however less is known regarding trained therapists’ decisions related to offering trauma-focused therapies or alternative treatment options. Thus, the aim of the current study was to examine therapist motivations to initiate CPT in community settings. The present study utilizes data from a larger investigation aiming to support the sustained implementation of Cognitive Processing Therapy (CPT) in community mental health treatment settings. Enrolled therapists participated in phone interviews discussing their opinions of CPT, preferred treatments for PTSD, and process in assessing appropriate PTSD treatments for clients. Semi-structured interviews (N = 29) were transcribed and analyzed using a directed content analysis approach. Several themes emerged regarding therapists’ decision-making in selecting PTSD treatments. Therapist motivations to use EBPs for PTSD, primarily CPT, were identified at the client (e.g., perceived compatibility with client-level characteristics), therapist (e.g., time limitations), and clinic levels (e.g., leadership support). The results provide insight into the complex array of factors that affect sustainability of EBPs for PTSD in community settings and inform future dissemination of EBPs, including training efforts in community settings.
Cultural Bias in Parent Reports: The Role of Socialization Goals When Parents Report on Their Child’s Problem Behavior
Authors: Runge Ronja A. , Soellner Renate
Published: November 2022

It has been called into question whether widely used screening instruments for child mental health can provide comparable results across countries and cultures. Socialization goals can influence whether and to what extent a parent considers a behavior to be problematic and thus might influence parental reports on their child’s behavior. We tested comparability of parental reports between native German (N = 116) and Turkish origin (N = 77) parents in Germany in an online study using a vignette approach. Parents were asked to rate the perceived problem severity of the same behavior depicted in the vignettes. We expected and found that parents of Turkish origin in Germany rate the externalizing problem behaviour depicted in the vignettes as more problematic compared to native German parents. The effect was fully mediated by parental approval of the socialization goals obedience and collectivism. We also controlled for social desirability responding and an extreme response style.
Sustainable Intensification Farming as an Enabler for Farm Eco-Efficiency?
Authors: Weltin Meike , Hüttel Silke
Published: November 2022

Sustainable Intensification (SI) practices offer adopters exploiting improvement potentials in environmental performance of farming, i.e. enhance ecosystem functionality, while maintaining productivity. This paper proposes a directional meta-frontier approach for measuring farms’ eco-efficiency and respective improvement potentials in the direction of farms’ ecological output for SI evaluation. We account for farms’ selection processes into SI using a behavioural model and rely on a matched sample for adopters and non-adopters of agronomic SI practices from the northern German Plain. We conclude that the SI adopters determined the sample’s system frontier and showed higher mean eco-efficiency, but that most farms in our sample did not fully exploit the improvement potentials in biodiversity as ecological outcome.
Name game: the naming history of the chemical elements—part 3—rivalry of scientists in the twentieth and twenty-first centuries
Authors: Miśkowiec Paweł
Published: November 2022

The third article of the “Naming game…” series presents the issues of naming elements discovered and synthesized in the twentieth and twenty-first centuries. Based on the source data, the publication time of the names of the last 35 chemical elements was identified. In the case of discoveries from the end of the twentieth century and the beginning of the twenty-first century, the principle was adopted of the priority of information about the synthesis of a new chemical element in scientific journals or conference reports. However, when the same information was published earlier in the news sections of scientific journals, in articles in popular science journals, and (in modern times) on the websites of interested research institutes, such an info is presented as well. It turned out that in some cases this information is very complex as the names of some elements were changed several times and published in different media in the same period. Therefore, this article is an attempt to sort out the issue of first publishing of the names of the last known 35 chemical elements.
Racial effects on Masimo pulse oximetry: a laboratory study
Authors: Barker Steven J. , Wilson William C.
Published: November 2022

Recent publications have suggested that pulse oximeters exhibit reduced accuracy in dark-skinned patients during periods of hypoxemia. Masimo SET® (Signal Extraction Technology®) has been designed, calibrated, and validated using nearly equal numbers of dark and light skinned subjects, with the goal of eliminating differences between pulse oximetry saturation (SpO2) and arterial oxygen saturation (SaO2) values due to skin pigmentation. The accuracy concerns reported in dark-skinned patients led us to perform a retrospective analysis of healthy Black and White volunteers. Seventy-five subjects who self-identified as being racially Black or White underwent a desaturation protocol where SaO2 values were decreased from 100 to 70%, while simultaneous SpO2 values were recorded using Masimo RD SET® sensors. Statistical bias (mean difference) and precision (standard deviation of difference) were − 0.20 ± 1.40% for Black and − 0.05 ± 1.35% for White subjects. Plots of SpO2 versus SaO2 show no significant visible differences between races throughout the saturation range from 70 to 100%. Box plots grouped in 1% saturation bins, from 89–96%, and plotted against concomitant SaO2 values, show that occult hypoxemia (SaO2 < 88% when SpO2 = 92–96%) occurred in only 0.2% of White subject data pairs, but not in any Black subjects. There were no clinically significant differences in bias (mean difference of SpO2-SaO2) found between healthy Black and White subjects. Occult hypoxemia was rare and did not occur in Black subjects. Masimo RD SET® can be used with equal assurance in people with dark or light skin. These laboratory results were obtained in well-controlled experimental conditions in healthy volunteers—not reflecting actual clinical conditions/patients.
Investigation of the modes of action for phosphorous flame retardants in a fully waterborne sugar-based epoxy resin
Authors: Aljamal Amer , Marosi György , Szolnoki Beáta
Published: November 2022

A fully waterborne epoxy system was prepared from waterborne sorbitol-based epoxy resin cured with an alkylated polyalkylene polyamine hardener. The flame-retardant property was accomplished by the application of different additive phosphorous flame retardants (FRs). Phosphonate polyol and ethyl ethylene glycol phosphate which are in the liquid phase, and two FRs in the form of fine-grained particles; aluminium diethyl phosphinate (AlPi), ammonium polyphosphate (APP). The flame-retardant epoxy resin blends were prepared at the same levels of phosphorus content. The results are very promising as the self-extinguishing behaviour was observed at 3%P for all the investigated FRs and at 1%P in the case of APP. Limiting oxygen index (LOI) values were practically good for all FRs and extremely improved in the case of APP. LOI was 48% for the APP sample at 3%P content. Furthermore, this blend showed the best results in the forced flaming conditions as the total heat release in cone calorimetry measurements (THR) decreased by 43% and the peak of heat release rate (pHRR) decreased by 65% with more elongated burning compared to the reference SPE matrix. The efficient solid-phase FR effect of APP was confirmed by scanning electron microscopic (SEM) and attenuated total reflection-infrared spectrometry (ATR-IR) analysis of the residual char after cone calorimetry measurements.
High dose craniospinal irradiation as independent risk factor of permanent alopecia in childhood medulloblastoma survivors: cohort study and literature review
Authors: Satragno C. , Verrico A. , Giannelli F. , Ferrero A. , Campora S. , Turazzi M. , Cavagnetto F. , Schiavetti I. , Garrè M. L. , Garibotto F. , Milanaccio C. , Piccolo G. , Crocco M. , Ramaglia A. , Di Profio S. , Barra S. , Belgioia L.
Published: November 2022

Purpose

Our aim was to determine the main risk factors related to the occurrence of permanent alopecia in childhood medulloblastoma (MB) survivors.

Methods

We retrospectively analyzed the clinical features of all consecutive MB survivors treated at our institute. We divided the patients into 3 groups depending on the craniospinal irradiation (CSI) dose received and defined permanent alopecia first in terms of the skin region affected (whole scalp and nape region), then on the basis of the toxicity degree (G). Any relationship between permanent alopecia and other characteristics was investigated by a univariate and multivariate analysis and Odds ratio (OR) with confidence interval (CI) was reported.

Results

We included 41 patients with a mean10-year follow-up. High dose CSI resulted as an independent factor leading to permanent hair loss in both groups: alopecia of the whole scalp (G1 p-value 0.030, G2 p-value 0.003) and of the nape region (G1 p-value 0.038, G2 p-value 0.006). The posterior cranial fossa (PCF) boost volume and dose were not significant factors at multivariate analysis neither in permanent hair loss of the whole scalp nor only in the nuchal region.

Conclusion

In pediatric patients with MB, the development of permanent alopecia seems to depend only on the CSI dose ≥ 36 Gy. Acute damage to the hair follicle is dose dependent, but in terms of late side effects, constant and homogeneous daily irradiation of a large volume may have a stronger effect than a higher but focal dose of radiotherapy.
The Trade Effects of the EU-South Korea Free Trade Agreement: Heterogeneity Across Time, Country Pairs, and Directions of Trade within Country Pairs
Authors: Jung Benjamin
Published: November 2022

The EU-South Korea Free Trade Agreement, which entered into force in 2015, is an example of so-called “second-generation” regional trade agreements. Using the gravity equation and drawing on a novel dataset on trade in manufacturing goods (Monteiro in World Trade Organization, Geneva, 2020), I explore the heterogeneity in the trade effects of this agreement across time (anticipation and phasing-in/delayed adjustment), country pairs, and across trading directions within pairs (exports versus imports). First, the positive trade effect after the announcement vanished one year prior to entry into force. Second, on average exports of EU countries to South Korea rise, while imports of EU countries are not significantly affected, potentially reflecting differences in ex ante trade policies. Third, additional imports caused by the agreement are larger for those EU countries where South Korea accounted for a large share of extra-EU imports already before the agreement.
Platelet function testing in atrial fibrillation patients undergoing percutaneous coronary intervention
Authors: Lianos Ioannis , Varlamos Charalampos , Benetou Despoina-Rafailia , Mantis Christos , Kintis Konstantinos , Dragona Vassiliki-Maria , Kanakakis Ioannis , Sionis Dimitrios , Patsilinakos Sotirios , Alexopoulos Dimitrios
Published: November 2022

Platelet function testing (PFT) could be a useful clinical tool to guide individualized antithrombotic treatment in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). We aimed to investigate platelet reactivity (PR) in the context of a contemporary registry. “Real-world” data were retrieved from a nationwide, multicenter, observational study of AF patients on oral anticoagulants (OAC) undergoing PCI. Patients treated with a P2Y12 inhibitor, namely clopidogrel or ticagrelor, as part of double or triple antithrombotic therapy, were submitted to PFT before discharge and were followed up for 12 months. Out of 101 patients included in the study, 66 were submitted to PFT while on clopidogrel and 35 while on ticagrelor; PR was 162.9 ± 68 PRU and 46.02 ± 46 PRU, respectively (P < 0.001). High on-treatment PR (HTPR) was observed in 15 patients under clopidogrel (22.7%); 7 of them escalated to ticagrelor. Low on-treatment PR (LTPR) was found in 9 clopidogrel and 28 ticagrelor-treated patients (13.6% vs. 80%, P < 0.001), of whom only 1 de-escalated to clopidogrel. PR did not differ by OAC regimen. PFT results had no impact on aspirin prescription at discharge, while failed to predict significant bleeding events at follow up. Ticagrelor administration led to lower PR and lower incidence of HTPR in comparison with clopidogrel. Physicians’ behavior in response to knowledge of a patient’s PR was variable. Further studies are required to elucidate the role of PFT as a tool to guide individualized antithrombotic treatment in this clinical scenario.
Genetic variation in fire recovery and other fire-related traits in a global eucalypt species
Authors: Hernández Mariano A. , Butler Jakob B. , Ammitzboll Hans , Freeman Jules S. , O’Reilly-Wapstra Julianne , Vaillancourt René E. , Potts Brad M.
Published: November 2022

To understand the potential of forests to adapt to wildfire, we studied the genetic architecture of fire-related structural, damage and recovery traits in a globally important Australian forest tree species, Eucalyptus globulus. Fourteen traits were evaluated in an outcrossed F2 population in a field trial in Tasmania, Australia, which was burnt by a wildfire 14 years after planting. The trial also included open-pollinated families of the grandparental dwarf and tall ecotypes used to produce the F2 population. We studied the phenotypic correlations within the F2 population and performed quantitative trait loci (QTL) analyses using a linkage map comprised of 472 markers. Ecotype comparisons revealed that almost all traits were under genetic control, with trees of the dwarf ecotype significantly more damaged and mainly recovering from lignotubers, whereas tall ecotype trees mainly recovered from epicormic resprouts extending for a variable height up the stem. Within the F2, tree size was negatively correlated with fire damage and positively correlated with recovery. Genetic control of fire-related traits was confirmed by the detection of 38 QTL in the F2 population. These QTL accounted for 4 to 43% of the phenotypic variation in these traits. Several QTL co-located and likely reflect pleiotropic effects. However, many independent QTL were detected, including QTL for crown consumption and trunk scorch, epicormic resprouting, resprout herbivory, and seedling establishment. The QTL detected argue that many genetically controlled mechanisms are responsible for variation in fire damage and recovery.
Application of individual and integrated pollution indices of trace elements to evaluate the noise barrier impact on the soil environment in Wrocław (Poland)
Authors: Hołtra Anna , Zamorska-Wojdyła Dorota
Published: November 2022

Trace elements emitted by road transport cause long-term contamination of road soils. This study showed the effect of the noise barrier on the spatial distribution of metals in soils at the City Centre Ring Road in Wrocław (Poland). Samples were taken along the barrier every 150 m and across the screen at distances of 0.5, 2.5, 5 (only on the left side), 10, 20, and 50 m from the noise screen on both sides of road no. 5. The contamination of soils was assessed with the use of commonly used individual pollution indices, integrated pollution indices based on the PI index or metal concentrations, and a potential ecological risk index (RI). The geoaccumulation index (Igeo) and the single pollution index (PI) indicate moderate contamination of soils by Cu, Pb, and Zn at most measuring points. The significant risk was reported from Cd in all samples. Integrated pollution indices, especially the PI_Nemerow, PI_avg, and RI confirm the poor quality of studied soils. The presence of elements in soil is related to anthropogenic factors. The spatial distribution of pollution indices and results of statistical analysis (HCA) indicate that Cr and Ni are of natural origin. Remaining elements (Cd, Pb, Cu, Zn) are of mixed origin with a large share from car transport (the significant Spearman’s correlation coefficients). In the case of cadmium, dendograms suggest the existence of an additional anthropogenic source, which is also confirmed by moderately strong correlations of this element with other metals.
Nickel removal from wastewater using electrocoagulation process with zinc electrodes under various operating conditions: performance investigation, mechanism exploration, and cost analysis
Authors: Shaker Omar A. , Safwat Safwat M. , Matta Minerva E.
Published: November 2022

Economically feasible approaches are needed for wastewater treatment. Electrocoagulation (EC) is an electrochemical treatment method that removes various pollutants from wastewater. It has grown in popularity over conventional treatment methods, especially in industrial wastewater, due to its high performance and the ability to remove toxic compounds. However, it is crucial to reduce the costs associated with EC for widespread implementation. It is also important to decrease nickel (Ni) concentrations in wastewater to prevent potential health and environmental problems. Therefore, this study investigates Ni removal from synthetic and real wastewater using electrocoagulation. Zinc, as a novel electrode, was used as the sacrificial anode. Several operating conditions were assessed, including current density, initial pH, electrolysis time, and spacing between electrodes. The maximum Ni removal efficiency, after 90 min, reached 99.9% at a current density of 10 mA/cm2 when the pH was 9.2 and the gap distance was 4 cm. The Ni removal rate reached 94.4% and 94.9% at a 2- and 6-cm spacing, respectively, after 90 min. Anode morphology, kinetic modeling, electrical energy consumption, and cost analysis were also investigated. The type of corrosion was uniform, which is easily predicted compared to pitting corrosion. The comparison between chemical coagulation and electrocoagulation was also reported. Experimental results indicated that the maximum Ni removal rates reached 99.89% after 90 min. The optimum spacing between electrodes was 4 cm, and the optimum current density was 10 mA/cm2. Additionally, the kinetic data were best represented through the second-order Lagergren model. The results demonstrated that the electrocoagulation performance was better than that of chemical coagulation for Ni removal. The maximum electrical energy consumption was 23.79 KWh/m3 for Ni removal.
Wet depositions of cations in forests across NADP, EMEP, and EANET monitoring networks over the last two decades
Authors: Chang Chung-Te , Yang Ci-Jian , Huang Jr-Chuan
Published: November 2022

Studies focused on emissions and acid deposition of sulfur (S) and nitrogen (N) and the consequent precipitation acidity have a long history. However, atmospheric depositions of cations play a critical role in buffering precipitation acidity, and providing cationic nutrients for vegetation growth lacks sufficient studies equally. The spatiotemporal patterns of cation depositions and their neutralization potential across broad scales remain unclear. Through synthesizing the long-term data in forest sites (n = 128) derived from three monitoring networks (NADP in Northern America, EMEP in Europe, and EANET in East Asia) on wet deposition of cations (Na+, NH4-N, K+, Mg2+, and Ca2+), this study assesses the temporal changes and spatial patterns of cation depositions and their neutralization potential over the last two decades. The results showed that the depositions of cationic nutrients were considerably higher in EANET compared to NADP and EMEP. The depositions of sea salt-associated sodium exhibited a significant transition from marine (> 15 kg ha−1 year−1) to inland (< 3.0 kg ha−1 year−1) forest sites attributable to the precipitation quantity and influences of sea spray. The higher emissions of NH3and particulate matter in East Asia explained the higher cation depositions in EANET than NADP and EMEP. The annual trends of cations revealed that only 20–30% of the forest sites showed significant changing trends and the sites widely spread across the three networks. Possibly, base cation (BC) deposition has reached a low and stable condition in NADP and EMEP, while it has high spatial heterogeneity in the temporal change in EANET. The difference in BC deposition among the three networks reflects their distinct development of economy. Our synthesis indicates that the annual trends of neutralization factor (NF) in NADP can be explained by the declining of acid potential (AP), not by neutralization potential (NP) as BC deposition has been stably low over the past two decades. Whereas, the concurrent decreases of AP and NP in EMEP or plateau period of both AP and NP in EANET have come to a standstill of acid neutralizing capacity.
Hippocratic Oaths for Mathematicians?
Authors: Rittberg Colin Jakob
Published: November 2022

In this paper I ask whether mathematicians should swear an oath similar to the Hippocratic oath sworn by some medical professionals as a means to foster morally praiseworthy engagement with the ethical dimensions of mathematics. I individuate four dimensions in which mathematics is ethically charged: (1) applying mathematical knowledge to the world can cause harm, (2) participation of mathematicians in morally contentious practices is an ethical issue, (3) mathematics as a social activity faces relevant ethical concerns, (4) mathematical knowledge itself may be ethically charged. I present a conceptual framework for oaths and discuss some empirical results on the effectiveness of oath-taking to foster morally praiseworthy behaviour. My findings suggest that enforcing oath-taking practices in mathematics is not currently a suitable means to foster ethically praiseworthy behaviour amongst mathematicians. Oaths can, however, provide needed edifying narratives about how to act ethically when acting as a mathematician.