bluuebunny/crossref_metadata_2025 huggingface dataset:
Experiences of violence and mental health outcomes among Asian American transgender adults in the United States
Authors: Becerra Monideepa B. , Rodriquez Erik J. , Avina Robert M. , Becerra Benjamin J.
Published: March 2021

Purpose

We addressed prevalence and factors associated with mental health outcomes (suicidal behavior and psychological distress) among Asian Americans (AA), who identify as transgender, a key group among sexual and gender minorities that is overlooked and understudied.

Methods

We used data from 2015 United States Transgender Survey during 2019–2020 with our population as census defined AA. Outcomes included suicidal ideation, suicidal thoughts, and serious psychological distress (SPD). Independent variables included any abuse, partner abuse, bathroom-related abuse, and additional covariates. Adjusted odds ratio and 95% confidence interval (aOR; 95% CI) for each outcome are adjusted for age, marital status, citizenship status, education level, employment status, as well as poverty status.

Results

Nearly 67% reported experiencing any abuse, 52% reported abuse from romantic/sexual partner(s), while 29% reported harassment/abuse when trying to use bathrooms. Moreover, 82% reported suicidal thoughts, 40% reported suicidal attempts, and 39% had SPD. Results demonstrated that any abuse/violence had higher odds of suicidal thoughts (adjusted odds ratio [aOR] = 2.67, 95% confidence interval (CI):[1.98–3.58], suicidal attempts (aOR = 2.83, 95% CI:[2.18–3.68]), and SPD (aOR = 1.56, 95% CI:[1.20, 2.04]). Abuse from romantic/sexual partners had higher odds of suicidal thoughts (aOR = 2.47, 95% CI:[1.76–3.47]), suicidal attempts (aOR = 2.17, 95% CI:[1.68–2.80]), and SPD (aOR = 2.72, 95% CI:[2.03–3.63]). Experience of harassment/abuse during bathroom use had increased odds of suicidal attempts (aOR = 1.81, 95% CI:[1.41–2.31]).

Conclusion

Exposure to violence is common among AA transgender individuals and related to negative mental health outcomes. Initiatives to reduce exposure to abuse and providing resources for trauma-informed care are imperative to improve health outcomes.
Immunoglobulin Replacement Therapy is critical and cost-effective in increasing life expectancy and quality of life in patients suffering from Common Variable Immunodeficiency Disorders (CVID): A health-economic assessment
Authors: van Wilder Philippe , Odnoletkova Irina , Mouline Mehdi , de Vries Esther
Published: March 2021

Background

Common variable immunodeficiency disorders (CVID), the most common form of primary antibody deficiency, are rare conditions associated with considerable morbidity and mortality. The clinical benefit of immunoglobulin replacement therapy (IgGRT) is substantial: timely treatment with appropriate doses significantly reduces mortality and the incidence of CVID-complications such as major infections and bronchiectasis. Unfortunately, CVID-patients still face a median diagnostic delay of 4 years. Their disease burden, expressed in annual loss of disability-adjusted life years, is 3-fold higher than in the general population. Hurdles to treatment access and reimbursement by healthcare payers may exist because the value of IgGRT is poorly documented. This paper aims to demonstrate cost-effectiveness and cost-utility (on life expectancy and quality) of IgGRT in CVID.

Methods and findings

With input from a literature search, we built a health-economic model for cost-effectiveness and cost-utility assessment of IgGRT in CVID. We compared a mean literature-based dose (≥450mg/kg/4wks) to a zero-or-low dose (0 to ≤100 mg/kg/4wks) in a simulated cohort of adult patients from time of diagnosis until death; we also estimated the economic impact of diagnostic delay in this simulated cohort.

Compared to no or minimal treatment, IgGRT showed an incremental benefit of 17 life-years (LYs) and 11 quality-adjusted life-years (QALYs), resulting in an incremental cost-effectiveness ratio (ICER) of €29,296/LY and €46,717/QALY. These results were robust in a sensitivity analysis. Reducing diagnostic delay by 4 years provided an incremental benefit of six LYs and four QALYs compared to simulated patients with delayed IgGRT initiation, resulting in an ICER of €30,374/LY and €47,495/QALY.

Conclusions

The health-economic model suggests that early initiation of IgGRT compared to no or delayed IgGRT is highly cost-effective. CVID-patients’ access to IgGRT should be facilitated, not only because of proven clinical efficacy, but also due to the now demonstrated cost-effectiveness.
The exposure risk to COVID-19 in most affected countries: A vulnerability assessment model
Authors: Cartaxo Adriana Nascimento Santos , Barbosa Francisco Iran Cartaxo , de Souza Bermejo Paulo Henrique , Moreira Marina Figueiredo , Prata David Nadler
Published: March 2021

The world is facing the coronavirus pandemic (COVID-19), which began in China. By August 18, 2020, the United States, Brazil, and India were the most affected countries. Health infrastructure and socioeconomic vulnerabilities may be affecting the response capacities of these countries. We compared official indicators to identify which vulnerabilities better determined the exposure risk to COVID-19 in both the most and least affected countries. To achieve this purpose, we collected indicators from the Infectious Disease Vulnerability Index (IDVI), the World Health Organization (WHO), the World Bank, and the Brazilian Geography and Statistics Institute (IBGE). All indicators were normalized to facilitate comparisons. Speed, incidence, and population were used to identify the groups of countries with the highest and lowest risks of infection. Countries’ response capacities were determined based on socioeconomic, political, and health infrastructure conditions. Vulnerabilities were identified based on the indicator sensitivity. The highest-risk group included the U.S., Brazil, and India, whereas the lowest-risk group (with the largest population by continent) consisted of China, New Zealand, and Germany. The high-sensitivity cluster had 18 indicators (50% extra IDVI), such as merchandise trade, immunization, public services, maternal mortality, life expectancy at birth, hospital beds, GINI index, adolescent fertility, governance, political stability, transparency/corruption, industry, and water supply. The greatest vulnerability of the highest-risk group was related first to economic factors (merchandise trade), followed by public health (immunization), highlighting global dependence on Chinese trade, such as protective materials, equipment, and diagnostic tests. However, domestic political factors had more indicators, beginning with high sensitivity and followed by healthcare and economic conditions, which signified a lesser capacity to guide, coordinate, and supply the population with protective measures, such as social distancing.
Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling
Authors: Iwasaki Naruhito , Terawaki Seigo , Shimizu Kouhei , Oikawa Daisuke , Sakamoto Hirokazu , Sunami Kishiko , Tokunaga Fuminori
Published: March 2021

Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine. Moreover, recent studies have revealed that macrophages, especially alternatively activated macrophages (M2) induced by T helper 2 (Th2) cytokines, such as interleukin (IL)-4 and IL-13, participate in the pathogenesis of allergic diseases. The major source of Th2 cytokines is antigen-specific Th2 cells. To elucidate the relationship between histamine, macrophages, and Th2 cells in allergic inflammation, we established a macrophage-Th2 cell co-culture modelin vitroand an antigen-specific Th2 cell transfer mouse model of rhinitis.In vitroanalyses indicated that macrophages produce histamine by interacting with antigen-specific Th2 cells through the antigen. Furthermore, Th2 cells and macrophages cooperatively elicited rhinitis in the mouse model. We determined that histamine induces Th2- and macrophage-elicited sneezing responses through H1 receptor signaling, whereas it induces nasal eosinophil infiltrations through H4 receptor signaling. Collectively, these results indicate a novel histamine production mechanism by macrophages, in which Th2 cells and macrophages cooperatively induce nasal allergic inflammation through histamine signaling.
PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity
Authors: Parry Helen M. , Dowell Alexander C. , Zuo Jianmin , Verma Kriti , Kinsella Francesca A. M. , Begum Jusnara , Croft Wayne , Sharma-Oates Archana , Pratt Guy , Moss Paul
Published: March 2021

PD-1 is expressed on exhausted T cells in cancer patients but its physiological role remains uncertain. We determined the phenotype, function and transcriptional correlates of PD-1 expression on cytomegalovirus-specific CD4+ T cells during latent infection. PD-1 expression ranged from 10–85% and remained stable over time within individual donors. This ‘setpoint’ was correlated with viral load at primary infection. PD-1+ CD4+ T cells display strong cytotoxic function but generate low levels of Th1 cytokines which is only partially reversed by PD-1 blockade. TCR clonotypes showed variable sharing between PD-1+ and PD-1- CMV-specific cells indicating that PD-1 status is defined either during T cell priming or subsequent clonal expansion. Physiological PD-1+ CD4+ T cells therefore display a unique ‘high cytotoxicity-low cytokine’ phenotype and may act to suppress viral reactivation whilst minimizing tissue inflammation. Improved understanding of the physiological role of PD-1 will help to delineate the mechanisms, and potential reversal, of PD-1+ CD4+ T cell exhaustion in patients with malignant disease.
The disavowal of dance as labour in popular Hindi cinema
Authors: Chakrabarti Pritha
Published: March 2021

In this article, I analyse screendance texts from Hindi cinema to introduce a theoretical framework called the ideology of amateurism which, I argue, made space within the narrative of the Hindi film for the ‘ideal’ Indian woman to dance publicly while simultaneously disavowing modernity. Through an analysis of selected film dance texts, I show how this turned the dancing heroine into the restorer of the moral order of the narrative. I argue that this ideology of amateurism amounted to a denial of dance labour, which was a necessary precondition for the cultural legitimation of the viewers’ desire for the screendancer in particular and a disavowal of the desire for modernity in general. Following this, I show how with the liberalization of the Indian economy and the rise of neoliberalism, and interestingly, also the replacement of the erstwhile ‘union-dancers’ on-screen Bollywood film dance texts today not only acknowledge the labour of screendance but promotional materials lay out the ‘labouring process’. This, I suggest, is symptomatic of the emergence of a new work order and the entry of a new class into this sphere. I read this in conjunction with the rise of dance as an established profession, as seen through the mushrooming of Bollywood dance schools, in order to show how the ideology of amateurism is challenged through a reconfiguration of work practices in neoliberal economies.
Kutatás-fejlesztési és innovációs hálózatok működése az autóiparban – Eltérő szerkezet, hasonló hatás?
Authors: Csonka László
Published: March 2021

A kutatás-fejlesztés és innováció hálózatosodása mára nyilvánvalóvá vált az evolucionista közgazdasági szakirodalom alapján. Magyarországon e folyamat lassabban és kisebb mértéket ért el, mint amit a szakirodalom alapján várhatnánk, nem függetlenül a kutatás-fejlesztési és innovációs (KFI) környezet általános gyengeségeitől. A kutatás hazai KFI-hálózatok vizsgálatával arra keresi a választ, hogyan épülnek fel és működnek a hazai KFI-hálózatok, milyen szerepet játszanak a partnervállalkozások képességeinek fejlesztésében? A kutatás két hazai, autóipari hálózat jellegzetességeit tárja fel, amelyek részt vesznek a regionális egyetemi tudásközpontokat támogató programban is. Noha a támogatás miatt a hálózat központi szereplői elvileg hasonló működési kereteket dolgoztak ki, a hálózatok szerkezete a gyakorlatban néhány fontos eltérést mutat. E különbségeknél azonban fontosabbak az azonosságok, amelyek a központi szereplők pozitív helyzetét és tevékenységét erősítik meg, szemben a hálózat peremén lévők korlátozottabb képességeivel és lehetőségeivel. A vizsgált hálózatoknak azonban így is nagyon nagy érdeme, hogy hozzájárulnak ahhoz a tanulási folyamathoz, amelynek során a hazai vállalkozások új tudást és új képességeket sajátíthatnak el – szakmai téren és az együttműködésekkel kapcsolatban is –, valamint olyan bizalmi viszonyokat alakíthatnak ki, amelyek hosszabb távú sikerességüket is megalapozhatja.
Ethik
Authors: Großmaß Ruth
Published: March 2021

Keine der soziologischen Untersuchungen Richard Sennetts ist rein analytischer Natur. Sennett wirft immer auch die Frage auf, wie gesellschaftliche Verhältnisse sein sollen, damit ein »gutes« oder zumindest akzeptables Leben möglich wird. Der Begründungsrahmen für die jeweils vorgenommenen Bewertungen allerdings ändert sich. In den Arbeiten der 1960er/70er Jahre ermöglicht eine kapitalismus-kritische, »linke« Grundhaltung die Bewertung der Lebensverhältnisse. Dann, ab Ende der 1970er Jahre treten moralische Kategorien (wie Freiheit, Selbstachtung, Respekt, Würde) in den Vordergrund - Kategorien, die in Interviews aufgefunden und weitgehend vom Autor geteilt werden. Da, wo diese Gemeinsamkeit nicht trägt (wie bei Solidarität als Moral der Nähe), findet eine argumentierende Abgrenzung statt, was in den Büchern der Trilogie (2008, 2012, 2018) in eine explizite Ethik mündet. Der Aufsatz setzt sich kritisch mit der argumentativen Tragfähigkeit von Sennetts Begründungen auseinander.
El apofatismo de Vladimir N. Lossky y su recepción crítica
Authors: Sutil Lorenzo José Alberto
Published: March 2021

El teólogo ortodoxo contemporáneo Vladimir N. Lossky (1903-1958) hizo del apofatismo o teología negativa una característica de su teología, en sintonía con los planteamientos del oriente cristiano. Su radicalismo en este aspecto ha sido criticado ampliamente. En este trabajo exponemos en primer lugar el apofatismo del autor estudiado. En este sentido descubrimos el apofatismo como una actitud teológica propia de la teología ortodoxa que se manifiesta en los diversos aspectos de la vida cristiana (el dogma de la Trinidad, el dogma de las energías divinas, la procesión del Espíritu Santo, la antropología, la liturgia, los iconos). En una segunda parte del estudio, recorremos las distintas aportaciones que conforman la recepción crítica del apofatismo losskiano (Tyszkiewicz, Florovsky, Williams, Stăniloae, Zizioulas, Rogobete, Bernardi, Prosperi, Papanikolau, Nichols, Clément), para concluir ofreciendo nuestra propia opinión al respecto.
Apuntes veterotestamentarios para una teología sistemática de la expiación
Authors: Medina Balguerías Marta
Published: March 2021

Para ayudar a clarificar el concepto de «expiación» este artículo busca rastrear sus principales elementos en la teología veterotestamentaria. Tras una panorámica de los usos del término en el Antiguo Testamento nos centramos en la expiación en el documento sacerdotal (donde es entendida en el marco de los sacrificios rituales) y después en su dimensión intercesora, con un especial detenimiento en la mediación del siervo de Yahveh del Deuteroisaías. Concluimos que la expiación es un proceso relacional en el que Dios borra el mal del ser humano y posibilita la reconciliación (con la participación de la persona y normalmente de un mediador).
Ein neues Konzept für die Optimierung intelligenter Aktoren im Bereich beweglicher elektrischer Verbraucher
Authors: Manz Friedrich
Published: March 2021

Die Einbindung von mobilen Anwendungen in den Produktionsablauf von Fertigungs- und Produktionsanlagen gewinnt immer mehr an Bedeutung, um Produktionsprozesse flexibel und effizient abzubilden. Ausgehend von diesen Anforderungen wird in dieser Dissertation ein intelligenter Aktor für mobile Anwendungen entwickelt. Der Aufbau des Aktors selbst ist in drei Bereiche unterteilt. Der erste Bereich beschreibt die Datenkommunikation und Datensynchronisation zwischen den stationären und den beweglichen Kommunikationsteilnehmern. Im zweiten Teil ist der Aufbau einer Hardwareplattform für einen intelligenten Aktor und die Umsetzung einer Motorsteuerung realisiert. Der letzte Bereich zeigt die Einbindung eines prädiktiven Regelungsverfahrens im Vergleich zu einem klassischen Regelungskonzept.
Avoided motifs: short amino acid strings missing from protein datasets
Authors: Mier Pablo , Andrade-Navarro Miguel A.
Published: March 2021

According to the amino acid composition of natural proteins, it could be expected that all possible sequences of three or four amino acids will occur at least once in large protein datasets purely by chance. However, in some species or cellular context, specific short amino acid motifs are missing due to unknown reasons. We describe these as Avoided Motifs, short amino acid combinations missing from biological sequences. Here we identify 209 human and 154 bacterial Avoided Motifs of length four amino acids, and discuss their possible functionality according to their presence in other species. Furthermore, we determine two Avoided Motifs of length three amino acids in human proteins specifically located in the cytoplasm, and two more in secreted proteins. Our results support the hypothesis that the characterization of Avoided Motifs in particular contexts can provide us with information about functional motifs, pointing to a new approach in the use of molecular sequences for the discovery of protein function.
Land Policy and Food Prices: Evidence from a Land Consolidation Program in Rwanda
Authors: Nsabimana Aimable , Niyitanga Fidele , Weatherspoon Dave D. , Naseem Anwar
Published: March 2021

Rwanda’s “Crop Intensification Program (CIP)” is primarily a land consolidation program aimed at improving agricultural productivity and food security. The program, which began in 2007, focuses on monocropping and commercialization of six priority crops: maize, wheat, rice, white potato, beans, and cassava. CIP has facilitated easy access to improved seed stocks, fertilizer, extension services, and postharvest handling and storage services. Although studies have documented the impact of CIP on changes in farm yield, incomes, and productivity, less is known about its impact on food prices. In this study, we examine the crop-food price differences in intensive monocropped CIP and non-intensive monocropped CIP zones in Rwanda. Specifically, the study evaluates price variations of beans and maize along with complementary food crops in intensive and non-intensive monocropped zones before and after the introduction of the CIP policy. We find that the CIP policy is not associated with differences in CIP crop prices between the intensive and non-intensive monocropped zones. Over time, prices increased for CIP crops but generally, the crop prices in the two zones were cointegrated. Prices for non-CIP crops in the two different zones did show price differentials prior to the implementation of CIP, with the prices in intensive monocropped zones being greater than in the non-intensive monocropped zones. Moreover, the prices in intensive areas are cointegrated with prices in non-intensive areas for maize and beans and these prices are converging. This indicates that farmers who intensively produced one CIP crop were able to go to the market and purchase other food crops and that price differences between zones have decreased over time, potentially making the CIP intensive farmers better off.
Highly birefringent photonic crystal fiber with D-shaped air holes for terahertz (THz) application
Authors: Wang Biao , Jia Chunrong , Yang Jiantan , Di Zhigang , Yao Jianquan
Published: March 2021

A new type of high birefringence terahertz (THz) band photonic crystal fiber (PCF) is proposed. D-shaped air holes are introduced into the core of the PCF and the cladding near the core. Some important parameters of this waveguide were researched in the range of 0.6–1.2 THz. The simulation results show that the proposed fiber has a high birefringence of 0.0425 at 0.7 THz. In addition, the confinement loss and the effective mode area are respectively 6.63 × 10−7 dB/m and 0.77 × 105 μm2, when the operating frequency is 1 THz and the high birefringence of 0.04 is maintained. At the same time, very low bending loss and near zero flat positive dispersion are obtained. And has single-mode operating characteristics in the entire research frequency range. The PCF structure will provide new solutions for the application of THz waves and the design of THz waveguides.
Epileptic phenotype in late-onset hyperinsulinemic hypoglycemia successfully treated by diazoxide
Authors: Descamps Justine , Ruello Cyril , Perge Kevin , de Bellescize Julitta , Saint-Martin Cécile , Nicolino Marc
Published: March 2021

Objectives

Serious hyperinsulinemic hypoglycemia (HH) is generally the main initial symptom of hyperinsulinism. Epilepsy, without any overt feature of hypoglycemia, might be a very rare initial presentation of late-onset isolated hyperinsulinism.

Case presentation

We describe a case of late-onset HH in a 15-year-old boy with a history of idiopathic generalized epilepsy, now named genetic generalized epilepsy (IGE/GGE), beginning with a tonic–clonic seizure at the age of 11 years. Subsequently, absences with rare eyelid myoclonia were recorded on electroencephalogram (EEG), followed by episodes of impaired consciousness with facial myoclonia. Neurological status was normal except attention-deficit hyperactivity disorder (ADHD). At the age of 15 years, an episode of slight alteration of consciousness with neurovegetative signs could be recorded, which did not correspond to an absence status. Hypoglycemia due to hyperinsulinism was documented (clinically, biologically, and genetically). Diazoxide treatment resolved the glycopenic symptoms, the non-hypoglycemic seizures and normalized brain electrical activity allowing complete withdrawal of antiepileptic medication.

Conclusions

Epilepsy can be a very rare initial feature of HH starting in childhood. The occurrence of atypical features in the context of GGE as “absence statuses” with unusual vegetative symptoms and facial myoclonia might be suggestive for HH. Careful assessment and specific treatment are necessary to prevent hyperinsulinism related brain damage. Our case showed that diazoxide might also resolve seizures and normalize EEG.
Establishment of analysis methodology of RADTRAD for Maanshan PWR ATWS
Authors: Lin H.-T.
Published: March 2021

In this research, the analysis methodology for Maanshan PWR nuclear power plant (NPP) ATWS (Anticipated Transient Without Scram) is established by using RADTRAD code. This methodology can evaluate the dose at Exclusion Area Boundary (EAB), Low Population Zone (LPZ), and control room for the Maanshan ATWS. In addition, there are four leakage pathways in the Maanshan ATWS that are containment leakage, containment low volume purge, steam generator leakage, and ESF leakage. Therefore, for these leakage pathways, the RADTRAD models are established. Finally, according to the analysis results, they are below the criteria of 10 CFR 100.11 for the EAB and LPZ and Standard Review Plan (SRP) for the control room. Additionally, the steam generator leakage gives the maximum dose in these leakage pathways.
Risk factors of left atrial appendage thrombus in patients with non-valvular atrial fibrillation
Authors: Liu Yaowu , Zhu Didi , Xiao Yunyun , Zhu Yeqian , Zhou Qianxing , Ren Liqun , Chen Long
Published: March 2021

Objective

To investigate the risk factors of left atrial appendage thrombus (LAAT) in patients with non-valvular atrial fibrillation (AF).

Methods

We collected the clinical data of patients with non-valvular AF who underwent transesophageal echocardiography (TEE) at the Zhongda Hospital of Southeast University between January 2016 and June 2019. The patients were divided into two groups, LAAT and non-LAAT. We performed comparative analysis, receiver operating characteristic (ROC) curve analysis and logistic regression analysis to estimate the risk factors of LAAT.

Results

A total of 442 patients with non-valvular AF were enrolled in the study. LAAT was detected by TEE in 20 cases (4.7%). Compared with patients without LAAT, patients with LAAT had higher CHA2DS2-VASc scores (3 vs 2, p = 0.001), higher values of D-dimer (180.0 vs 90.0 μg/L, p = 0.003), larger LA anteroposterior diameters (50.5 vs 41.0 mm, p < 0.001) and higher ratios of non-paroxysmal AF (85.0% vs 23.6%, p < 0.001). ROC curve analysis revealed that the cutoff value of LA anteroposterior diameter was 49.5 mm. After adjusting for other confounders, logistic regression analysis showed that enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independently associated with higher risks of LAAT (OR = 7.28, 95% CI: 2.36–22.47; OR = 8.89, 95% CI: 2.33–33.99, respectively). The proportions of LAAT in patients with larger LA (anteroposterior diameter ≥49.5 mm), non-paroxysmal AF and both larger LA and non-paroxysmal AF were 30% (12/40), 15.2% (17/112) and 39.1% (9/23), respectively.

Conclusion

Enlarged LA (anteroposterior diameter ≥49.5 mm) and non-paroxysmal AF were independent risk factors of LAAT in non-valvular AF patients.
Synergistic strengthening mechanism of copper matrix composite reinforced with nano-Al2O3 particles and micro-SiC whiskers
Authors: Lin Huanran , Guo Xiuhua , Song Kexing , Feng Jiang , Li Shaolin , Zhang Xiangfeng
Published: March 2021

Although Cu–Al2O3 composites have good comprehensive performance, higher mechanical properties and arc erosion resistance are still required to meet heavy-duty applications such as electromagnetic railguns. In this work, a novel hybrid SiCw/Cu–Al2O3 composite was successfully prepared by combining powder metallurgy and internal oxidation. The microstructure and mechanical behavior of the SiCw/Cu–Al2O3 composite were studied. The results show that nano-Al2O3 particles and micro-SiCw are introduced into the copper matrix simultaneously. Well-bonded interfaces between copper matrix and Al2O3 particles or SiCw are obtained with improved mechanical and arc erosion resistance of SiCw/Cu–Al2O3 composite. The ultimate tensile strength of the SiCw/Cu–Al2O3 composite is 508.9 MPa, which is 7.9 and 56.1% higher than that of the Cu–Al2O3 composite and SiCw/Cu composite, respectively. The strengthening mechanism calculation shows that Orowan strengthening is the main strengthening mechanism of the SiCw/Cu–Al2O3 composite. Compared with Cu–Al2O3 composite, the hybrid SiCw/Cu–Al2O3 composite has lower arc time and energy and better arc stability.
Integrated weed management practices and sustainable food production among farmers in Kwara State, Nigeria
Authors: Imoloame Emmanuel Oyamedan , Ayanda Ibrahim Folorunsho , Yusuf Olayinka Jelili
Published: March 2021

A survey was conducted in the Kwara State of Nigeria to study the integrated weed management (IWM) practices by farmers. This was in view of the poor weed management practices adopted by farmers, which is a major factor responsible for low yields of many arable crops in Kwara State. A multi-stage sampling technique was used to select a sample size of 480 respondents, and a structured interview schedule was used to elicit information from them. Data obtained were analyzed using descriptive statistics. Factor analysis was also carried out to examine the perception of farmers’ benefits of IWM. Results showed that the majority of farmers (29.4%) were youths, married (89.1%), and involved in medium-scale farming (47.2%). Furthermore, 50.8% of the farmers had primary or secondary education. Although farmers use different weed control methods, more than half of them (54.7%) use herbicides. Most farmers (92.6%) are engaged in the use of IWM, However, 73.5% of them use a combination of herbicides and hoe weeding. Although not properly practiced, farmers perceived IWM as having socio-environmental (29.229%) and techno-efficacious (23.495%) benefits over either hoe weeding or herbicides used alone. The findings suggest a need to train farmers on all aspects of IWM to achieve self-sufficiency in food production in Kwara State.
W-Chirped optical solitons and modulation instability analysis of Chen–Lee–Liu equation in optical monomode fibres
Authors: Inc Mustafa , Yakada Salathiel , Bienvenu Depelair , Betchewe Gambo , Chu Yu-Ming
Published: March 2021

This work was devoted to unearth W-chirped to the famous Chen–Lee–Liu equation (CLLE) in optical monomode fibres. The results obtained will be useful to explain wave propagating with the chirp component. To attempt the main goal, we have used the new sub-ordinary differential equation (ODE) technique which was upgraded recently by Zayed EME, Mohamed EMA. Application of newly proposed sub-ODE method to locate chirped optical solutions to the Triki–Biswas equation equation. Optik. 2020;207:164360. On the other hand, we have used the modulation analysis to study the steady state of the obtained chirped soliton solutions in optical monomode fibres.
Sounds and gestures of linguistic reference: the endurance of reality in the poetry of Wallace Stevens
Authors: Levi Melih
Published: March 2021

The article seeks a rapprochement between pragmatic and semantic theories of language by returning to a breaking point in the history of philosophy, the middle of the twentieth century, when these theoretical models began to evolve into distinct schools of thought. Philosophical accounts of this period explore various and intertwined dependencies between semantics and context; however, they only implicitly examine the potential of sounds and bodily gestures in bringing descriptive clarity to the modes and limits of such dependencies. The article first investigates the way W. V. Quine conceptualized linguistic reference by combining behavioral models of language acquisition with more systematic explorations of syntax. It then turns to P. F. Strawson’s revisionary accounts of Kantian philosophy which reassess the silent strains of empiricism in Kant’s framework in order to identify possible grounds of reconciliation between pragmatic and semantic theories of language. Sound and gesture, two aspects that supplement language and give it an embodied feeling, are suggested as possible devices for formalizing intersections between context and semantic-oriented approaches. Poems by Wallace Stevens are used to think about the endurance of reference and how this endurance can find more compelling demonstration through an investigation of language as an embodied phenomenon.
Integration Analysis of m6A Regulators and m6A-Related Genes in Hepatocellular Carcinoma
Authors: Xie Jingdun , Qi Zhenhua , Luo Xiaolin , Yan Fang , Xing Wei , Zeng Weian , Chen Dongtai , Li Qiang
Published: March 2021

Background: N6-Methyladenosine (m6A) RNA methylation of eukaryotic mRNA is involved in the progression of various tumors. We aimed to investigate m6A-related genes and m6A regulators in hepatocellular carcinoma (HCC) and their association with prognosis in HCC.

Methods: We downloaded liver cancer sample data from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium database. A total of 21 m6A regulators and 1258 m6A-related genes were then analyzed by consensus clustering, Spearman’s correlation, GO, KEGG, LASSO Cox regression, and univariate Cox regression analyses. Finally, we constructed a risk prognostic model.

Results: We obtained 192 candidate m6A-related genes and 3 m6A regulators, including YTHDF1, YTHDF2, and YTHDC1. The expression of these genes and regulators differed significantly in different stages of HCC. Based on Cox regression analysis, 19 of 98 m6A-related prognostic genes were obtained to construct a risk score model. The 1- and 3-year area under the curves (AUCs) among HCC patients were greater than 0.7. Finally, based on analysis of mutation differences between high- and low-risk score groups, we determined that TP53 had the highest mutation frequency in the high-risk HCC patient group, whereas titin (TTN) had the highest mutation frequency in the low-risk HCC patient group.

Conclusion: This study comprehensively analyzed m6A regulators and m6A-related genes through an integrated bioinformatic analysis, including expression, clustering, protein–protein interaction, and prognosis, thus providing novel insights into the roles of m6A regulators and m6A-related genes in HCC.
Monitoring Corals from Rescue to Care with ArcGIS and Flickr
Authors: James Deborah
Published: March 2021

This article intervenes in disaster media research by investigating the complex system of mediation that is required to mitigate coral disease and to monitor coral rescue and care. Stony coral tissue loss disease, discovered in 2014, has rapidly infected more than 50 percent of the Florida Reef Tract, the only living barrier reef in the continental United States. In response, reef managers have established a coral rescue team tasked with carrying out a phased coral rescue plan. In conjunction with that plan, the Coral Rescue–Coral Monitoring Dashboard interface and a corresponding Coral Rescue photo series hosted on Flickr were launched in 2019. This article explores the Dashboard and the Flickr photo series together as a single form of media introduced and discussed as “intermediation monitoring.” As a dynamic human-animal interface where coral tissue emerges, the Dashboard materializes coral agency and instantiates protocols for care: collection, gene sampling, and preparation for housing and transport to land-based aquarium facilities. The article further demonstrates how complex systems can be connected to one another—Dashboard to photos, technological system to the system of living things, and complex coral systems to human systems—in order to produce the mutually constitutive human-animal relationship between corals and humans as caregivers across the corals’ lives. Also emphasized are the ways that digital animal-human interfaces can be used to enact disaster relief.
Ritualizing Madness: Case Files as Sites of Enforced Performativity, 1894-1950
Authors: Smith Kira A.
Published: March 2021

In this article, I argue that case files kept by doctors, nurses, and attendants in Canadian Asylums, act as sites of performative madness enforced by the observer. In applying Foucauldian and performance theories, I look at the production of knowledge, and influence of power, which allow for the encoding of madness as a ritualized behaviour that is repeatable outside of the individual being recorded as mad. To illustrate this point, I use several case files from the Brockville Asylum to highlight how certain physical characteristics and behaviours were pathologized to support the medical argument that the inmate in question was in fact mad and belonged in the asylum. I suggest that one is not born mad, but they become mad through enforced ideas of madness, which enforced by the observer’s categorization of a physical characteristic or behaviour as mad.
Asymptotic Behavior of Boson Regge Trajectories
Authors: Trushevsky A.A.
Published: March 2021

The asymptotic behavior of boson Regge trajectories is studied. Upper and lower bounds on the asymptotic growth of the trajectories are obtained using the phase representation for the trajectories and a number of physical requirements. It is shown that, within the assumptions made, the asymptotic behavior of the trajectories is a square root.
The EXCEL Trial: The Interventionalists’ Perspective
Authors: Hunter George William , Sharma Vinoda , Varma Chetan , Connolly Derek
Published: March 2021

Left main stem (LMS) disease is identified in up to 5% of diagnostic angiography cases, and is associated with significant morbidity and mortality due to the proportion of myocardium it subtends. In the past 10 years, there has been a significant change in the way we contemplate treating lesions in the LMS due to evolving experience and evidence in percutaneous coronary intervention (PCI) strategies and technologies. This has been reflected in recent changes in European and International guidance on managing patients with this lesion subset. Here, the authors provide an overview of the current literature regarding the management of LMS disease using PCI in light of new developments and emerging concepts in this field, specifically looking at the recent EXCEL trial.
Role of clinical-anamnestic data in adenomyosis development at the present stage
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Prudnikov P.M.
Published: March 2021

The objective: to study a role of clinical-anamnestic data in development and an adenomyosis current at the present stage. Patients and methods. Еxamination of 110 patients, from which 60 – patients with an adenomyosis of different degree of activity and prevalence – the main group was conducted. Depending on degree of expression of the main clinical implications, characteristic for the adenomyosis, all studied patients with an adenomyosis (n=60) conditionally were divided into 2 clinical subgroups: 1.1 – the subgroup was made by 38 patients with clinically "active" adenomyosis; 1.2 a subgroup – 22 patients with clinically "inactive" adenomyosis. The control group was made by 50 patients of genesial and premenopausa age without adenomyosis Results. As a result of the analysis of preliminary diagnoses at pre-hospital stage at patients with an adenomyosis their appreciable heterogeneity was taped. So, from 60 patients at 50% this diagnosis was made correctly, at 18.7% the adenomyosis was mistakenly taken for a hysteromyoma, at 11.7% – for hyperplasia and polyps an endometrium, at 6.7% – for dysfunctional uterine bleedings; at 3.3% – for cystoadenoma an ovary. 10.0% of patients a long time were surveyed and treated at the neuropathologist, the gastroenterologist, the therapist with suspicion on disk hernia, osteochondrosis, colitis, adherent process and so forth Conclusin. On the basis of clinical-anamnestic yielded and results of gynecologic inspection the adenomyosis was suspected at 48 patients, from them is confirmed – in 28 cases. The share of false positive results made 41%. At the same time from 60 patients with the confirmed adenomyosis, in the clinical diagnosis this pathology was taken out at 31. Thus, the share of false-negative results made 48%. Sensitivity of a method – 51.7%, specificity – 59%. The received results need to be considered at early diagnostics and adenomyosis forecasting. Key words: adenomyosis, clinic, anamnesis, diagnostics.
Peculiarities of the uterine contractile activity in pregnant with mild preeclampsia at labor
Authors:   Azerbaijan Medical University, Baku, Abbasova N.V. , Aliyeva E.M. ,   Azerbaijan Medical University, Baku, Akhmed-zade V.A. ,   Azerbaijan Medical University, Baku, Ismailova A.Dj. ,   Azerbaijan Medical University, Baku
Published: March 2021

The objective: to study the contractile activity of the uterus in pregnant with mild preeclampsia at labor. Patients and methods. Was studies contractile activity of the uterus during the labor in 93 pregnant with mild preeclampsia. The average age of women was 25.24±0.42 (17–37 years). The duration of the clinical manifestation of mild preeclampsia was 3.2±0.1 (1 week). The contractile activity of the uterus was evaluated by the method of external cardiotocography. Results.There was confirmed, that pregnant with mild preeclampsia had high indicators of uterine contractile activity at the latent phase, including intense of the cramps 43.78±2.32 mm Hg , duration of the cramps – 28.32±1.1 s, dutation of relaxation – 43.44±1.46 s, total duration of the cramps – 71.76±1.27 s, duration of the uterine cycle – 66.55±0.28 s. And this leads to significant decreasing of the duration of the latent phase 1.24±0.11 hour, and decreasing of the total labor time (9.18±0.22 hours) appropriately. Conclusion. In parturient women with mild preeclampsia, high rates of contractile activity of the uterus in the latent phase, what significantly reduce the duration of the latent phase, and the total duration of labor as well. Key words: mild preeclampsia, contractile activity of the uterus, latent phase of the labor, active phase of the labor, intranatal cardiotocography.
Features of the genesial and somatic anamnesis at pregnant women with an undifferentiated dysplasia of connecting tissue
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Kostiuk A.L.
Published: March 2021

The objective: to study features of the somatic and genesial anamnesis at pregnant women with an undifferentiated dysplasia of connecting tissue for possibility of early diagnostics of the subsequent obstetric and perinatal complications. Patients and methods. 100 patients with clinical-laboratory signs an undifferentiated dysplasia of connecting tissue are surveyed. On the basis of the received results of the patient were divided into two groups: the main – 50 women (expression і6 points) regarded as patients with the expressed undifferentiated dysplasia of connecting tissue and group of comparison – 50 women (expression <6 points), regarded as patients without the connecting tissue expressed by an undifferentiated dysplasia. Results. Results of the conducted researches testify to an important role of the established features of the somatic and genesial anamnesis at pregnant women with clinical-laboratory and functional signs of an undifferentiated dysplasia of a connecting tissue. Conclusion. The received results need to be used for carrying out pregravidarny preparation and forecasting of possible obstetric and perinatal complications at pregnancy. Key words: undifferentiated dysplasia of connecting tissue, genesial and somatic anamnesis.
"Go Mobile" Perpustakaan di Era Digital
Authors: A. Lubis Nasrul Rizal
Published: March 2021

ABSTRAK“Now that everything is digital” Perkembangan teknologi informasi dan komunikasi membawa banyak perubahan di berbagai sektor. Baik itu corporate maupun lembaga yang bergerak di bidang jasa dan teknologi. Teknologi informasi dan komunikasi merubah aktivitas menjadi cepat, akurat dan fleksibel. Perpustakaan sebagai pusat data dan informasi sudah selayaknya memanfaatkan teknologi informasi dalam manajemen pengelolaan dan pengolahan koleksi yang ada. Penggunaan Go Mobile dalam manajemen perpustakaan diharapkan akan menjadikan perpustakaan bisa diakses dari mana saja dengan lebih mudah dan bersahabat. Penggunaan teknologi informasi akan membuat perpustakaan lebihberkembang sesuai dengan kebutuhan pemustakanya.ABSTRACT“Now that everything is digital” The development of information and communication technology brings many changesin various sectors. Whether it is corporate or institute engaged in the field of services and technology. Information andcommunication technologies change activity to be fast, accurate and flexible. Library as a data center and informationshould be utilizing information technology in the management management and processing of existing collections. Theuse of Go Mobile in library management is expected to make the library accessible from anywhere with more ease andfriendship. The use of information technology will make the library more developed in accordance with the needs of thelibrarian.
MANAJEMEN KEARSIPAN DALAM MENUNJANG KEGIATAN ADMINISTRASI PELAYANAN PUBLIK PADA SEKOLAH USAHA PERIKANAN MENENGAH SORONG DI LINGKUNGAN KEMENTERIAN KELAUTAN DAN PERIKANAN
Authors: Fakaubun Arfa
Published: March 2021

Dilihat dari perkembangan ilmu pengetahuan dan teknologi yang sangat pesat dewasa ini membawa pengaruh terhadap seluruh kegiatan yang dilakukan oleh setiap instansi, oleh sebab itu perlu ditingkatkan manajemen kearsipan dalam menunjang kegiatan administarsi pengelolaan arsip yang baik dan benar agar menjadi sumber informasi publik. karena sangat menunjang kecepatan dan ketepatan penyajian informasi, serta dapat membantu semua pihak dalam rangka melancarkan penyelesaian tugas, guna mencapai tujuan yang telah ditentukan. maka perlu dipahami tentang seluk beluk kearsipan sehingga dapat mengatasi masalah yang dihadapi oleh instansi Pemerintah maupun swasta, seperti pada Sekolah Usaha Perikanan Menengah Sorong yang notabenya sebagai Sekolah Kejuruan di bidang Perikanan, maka perlu di dukung dengan Sarana dan Prasarana Pendidikan yang disebut dengan manajemen kearsipan, sehingga dapat mewujudkan informasi pelayanan administrasi yang baik dan benar, yang diamanatkan dalam Undang-Undang Nomor 43 Tahun 2009 tentang Kearsipan dan Undang-Undang Nomor 20 Tahun 2003 tentang Sistem Pendidikan Nasional. Judging from the rapid development of science and technology today under the influence of all activities carried out by each agency, therefore it is necessary to improve the management of archives in supporting the administration of good and correct records management in order to become a source of public information. because it greatly supports the speed and accuracy of the presentation of information, and can help all parties in order to expedite the completion of the task, in order to achieve the specified goals. then it needs to be understood about the ins and outs of archiving so as to overcome the problems faced by government and private agencies, such as the Sorong Middle Fisheries Business School which in fact is a Vocational School in the field of Fisheries, it needs to be supported with Educational Facilities and Infrastructure called archival management, so that it can realize good and correct administrative service information, which is mandated in Act Number 43 of 2009 concerning Archives and Act Number 20 of 2003 concerning the National Education System.
RESIKO IMPLEMENTASI CLOUD COMPUTING DAN PENANGANANNYA DALAM MENDUKUNG RISET KELAUTAN DAN PERIKANAN
Authors: Mustikasari Eva , Saepulloh Dani
Published: March 2021

Riset adalah proses mengumpulkan, menganalisis, dan menerjemahkan informasi atau data secara sistematis untuk menambah pemahaman kita terhadap suatu fenomena tertentu yangmenarik perhatian kita. FORMAL RESEARCH yaitu riset yang ditujukan untuk menambah pemahaman kita terhadap suatu fenomena dan untuk dikomunikasikan kepada komunitas (dipublikasikan) melalui media internet (online) dengan menggunakan teknologi cloud Computing.Menggunakan Cloud Computing harus diperhatikan keamanan data agar pengguna memiliki kepercayaan dalam menggunakannya. Pengembangan cloud computing akan mengarah padaberkembangnya suatu teknologi pengiring cloud computing yaitu suatu bentuk teknologi yang dapat menjamin keamanan data. Selain itu, perkembangan cloud computing ini selanjutnya akanmemasuki tahap integrasi antar berbagai provider dengan mengedepankan prinsip interoperabilitas.Research is the process of collecting, analyzing, and systematically translating information or data to increase our understanding of a particular phenomenon that interests us. FORMAL RESEARCH, which is research aimed at increasing our understanding of a phenomenon and to be communicated to the community (published) via the internet (online) using cloud computing technology. Using Cloud Computing data security must be considered so that users have confidencein using it. The development of cloud computing will lead to the development of a technology that accompanies cloud computing, which is a form of technology that can ensure data security. In addition, the development of cloud computing will then enter the integration stage between various providers by prioritizing the principle of interoperability.