bluuebunny/crossref_metadata_2025 huggingface dataset:
HALP and PNI Score as Predictors of Nutritional Status in the Incidence of Incisional Hernia after Laparotomy in Colorectal Cancer Patients: A Case-Control Study
Authors: Nurasti Wawan Suci , Handaya Adeodatus Yuda , Barmawi Agus , Anwar Sumadi Lukman
Published: September 2024

Background: Colorectal cancer ranks as the third most common cancer in the world. If patients can still be resected, surgical therapy is carried out. An incisional hernia is one of the complications after laparotomy surgery. Nutritional status can influence the incidence of incisional hernias after laparotomy. Colorectal cancer patients must have their nutritional status assessed using a simple scoring. This research aims to evaluate Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) and Prognostic Nutritional Index (PNI) scores as a predictor of incisional hernia after laparotomy surgery in colorectal cancer patients at Dr. Sardjito General Hospital, Yogyakarta. Methods: This study uses a case-control study design which consisted of two groups, a case group of colorectal cancer patients with incisional hernias after laparotomy surgery and a control group of colorectal cancer patients without incisional hernias. The independent variable was nutritional status which was assessed by HALP and PNI score, and the dependent variable was incisional hernia. This research by taking data from laboratory patients at Dr. Sardjito General Hospital, Yogyakarta. For multivariate analysis, a logistic regression test was used with a significance value of p 0.05. Results: There is a relationship between the stage of cancer and the comorbid diabetes mellitus with the incidence of incisional hernias after laparotomy, this can be seen in the results of the chi-square test. Advanced stage has an OR of 13 (P=.001; OR=13; 95% CI 3.551-47.597), while comorbid diabetes mellitus has an OR of 6.571 (P=.002; OR=6.571; 95% CI 2.109-20.479). However, there is no correlation between the HALP and PNI score with the incidence of incisional hernia after laparotomy. The multivariate analysis results in HALP score have a significant correlation between the nutritional status and the incidence of incisional hernia with OR=17.981 (p= 0.037 OR=17; 95% CI 1.198-269.803). Conclusions: The HALP score can be used as a screening predictor in the incidence of incisional hernia after laparotomy for colorectal cancer patients.
DEVELOPMENT OF AN INTERACTIVE WEBSITE WITH DIDACTIC GAMES TO ENHANCE VOCABULARY IN YOUNG STUDENTS WITH INTELLECTUAL DISABILITIES
Authors: Bober Anna , Kosenko Yuriy , Korol Olena
Published: September 2024

The article investigates the development of a website that includes interactive didactic games designed to improve the vocabulary of primary schoolchildren with intellectual disabilities. It describes the importance of developing vocabulary in children with intellectual disabilities and shows how the game approach can be an effective tool for teaching and developing speech in this category of children. The process of developing a website with didactic games is considered, which includes the selection of appropriate software, interface design, development of interactive tasks and games, as well as testing and improvement of the website. In particular, the article discusses methods and approaches to creating games aimed at developing lexical skills, expanding vocabulary and improving communication skills in children with intellectual disabilities. The advantages of using interactive didactic games in the educational process of junior schoolchildren with intellectual disabilities are highlighted. They stimulate children's interest in learning words and expanding their vocabulary, develop cognitive and speech skills, improve memory and concentration, and increase motivation and enjoyment of learning. A game-based approach can keep children interested, motivated, and effective, helping them to develop their language skills and achieve greater academic success. The website was created on the wix platform. The collection of didactic games was developed on the LearningApps platform. There are various types of tasks, for example quizzes, puzzles, crosswords, matching exercises, etc. Images for didactic games were generated by playground.ai artificial intelligence, which opens up new opportunities for creating visually appealing games and tasks. The importance of developing website with interactive didactic games for the development of vocabulary of younger students with intellectual disabilities is emphasized, they can become an effective tool for teaching and developing speech in children of this category, contributing to their success in learning and overall development.
USING 5E INSTRUCTIONAL MODEL WITH ICT SUPPORT IN TEACHING LOWER SECONDARY STUDENTS ON THE TOPIC OF LIGHT REFLECTION
Authors: Pacala Frank Angelo
Published: September 2024

The educational process has become more accustomed to active classroom engagement. Physics teaching should focus more on young pupils’ investigative journey. This research investigates the effect of the ICT-based 5Es instructional model on the conceptual understanding and science process skills of grade 6 pupils on light reflection. The 5E Model stands for Engage, Explore, Explain, Elaborate, and Evaluate. The study used a mixed-method design involving 24 students participating in a 5E-based intervention. The pre- and post-test results showed a significant improvement in conceptual knowledge and science process skills. Statistical analysis using paired t-tests and Cohen's d found that the 5E Model has significantly improved students' conceptual understanding of the topic and their science process skills. The study also used a phenomenological analysis and identified three critical themes that contributed to the success of the intervention. These themes were high interest and excitement in using laboratory materials, collaboration among students in exploring light reflection, and teacher scaffolding and facilitation to help students overcome challenges. The 5Es Model, which involves engaging, examining, explaining, elaborating, and evaluating stages, was highly influential in keeping students interested and enthusiastic throughout the learning process. The study confirms that the 5Es instructional model positively impacts students’ science process skills and conceptual understanding. Using both quantitative and qualitative analyses provides a thorough understanding of the intervention’s effectiveness and offers recommendations for improving the implementation of the 5Es Model in science education. This study recommended providing professional development opportunities for teachers to enhance their skills in implementing the 5Es instructional model. Regular workshops, collaborative sessions, and opportunities for knowledge exchange can equip teachers with up-to-date teaching strategies and insights.
Sistematização da assistência de enfermagem ao paciente adulto vítima de traumatismo cranioencefálico grave: Relato de caso
Authors: Sacramento Karina Luiza Oliveira , Barros Luana Souza Lima , Silva Ediméia Mendes , Gomes Rosilene Silva , Jesus Jaqueline Santos de , Cunha Juliana Xavier Pinheiro da , Silva Drieli Oliveira , Biondo Chrisne Santana
Published: September 2024

Objetivo: Relatar o caso de um paciente adulto politraumatizado em uma unidade hospitalar, por meio da Sistematização da Assistência de Enfermagem, com enfoque no Trauma Crânio Encefálico (TCE). Método: Estudo descritivo e observacional, do tipo caso clínico, realizado em um hospital público do sudoeste baiano. A coleta de dados foi realizada através de anamnese, exame físico e dados coletados no prontuário. Utilizou-se o NANDA, NIC e NOC para determinar os diagnósticos e intervenções de enfermagem. Resultados: Identificaram-se vinte e sete diagnósticos de enfermagem relacionados aos domínios do NANDA. Conclusão: O estudo evidenciou a importância da assistência de enfermagem na prestação de cuidados ao paciente vítima de TCE, destacando a importância de uma avaliação individualizada, capaz de favorecer uma abordagem rápida e eficaz, para alcançar um bom prognóstico. A Sistematização da Assistência de Enfermagem possibilitou uma intervenção precisa e assertiva, o que é essencial em casos de TCE grave.
Educação Inclusiva no ensino de Ciências e Biologia: Uma perspectiva a partir da formação docente
Authors: Viana Rosângela Silva de Araújo , Almeida Delma Holanda de
Published: September 2024

O artigo apresenta uma análise sobre a educação inclusiva no ensino de Ciências e Biologia, contextualiza historicamente o desenvolvimento da educação inclusiva no Brasil e internacionalmente, destacando marcos como a criação de instituições para pessoas com deficiência e a influência de documentos como a Declaração Universal dos Direitos Humanos e a Lei de Diretrizes e Bases da Educação Nacional. O estudo enfatiza a importância da participação ativa dos alunos no processo de aprendizagem, com ênfase na formação docente como elemento-chave para promover uma educação inclusiva. A metodologia adotada envolve uma revisão bibliográfica qualitativa, tendo o objetivo de buscar artigos relacionados à formação de professores de Ciências/Biologia na perspectiva da educação inclusiva. Os resultados e discussão destacam a importância das disciplinas de Ciências e Biologia no currículo escolar e a necessidade de adaptar as práticas de ensino para atender às necessidades individuais dos alunos, especialmente aqueles com deficiência. São abordados desafios enfrentados pelos educadores, como a falta de formação inicial em educação inclusiva e a escassez de recursos didáticos adequados. A formação contínua dos professores é ressaltada como fundamental para superar esses obstáculos e promover uma prática pedagógica mais eficaz e inclusiva.  A pesquisa destaca também a dimensão política da educação e a importância de promover debates abrangentes e contínuos sobre a inclusão escolar. Em suma, o artigo enfatiza a urgência de adotar abordagens inclusivas e adaptativas para garantir uma educação de qualidade para todos, reconhecendo a necessidade de esforços coletivos para alcançar esse objetivo.
Desenvolvimento de plântulas de tomate cultivar Bartô sob o efeito de diferentes doses de extrato de algas marinhas
Authors: Panzarin Ana Lívia Jacob , Martins Bruno Novaes Menezes
Published: September 2024

O uso de extratos de algas marinhas na agricultura, principalmente o Ascophyllum nodosum, constitui uma alternativa ecologicamente correta ao uso de biofertilizante. Embora haja grande importância no desenvolvimento vegetal, poucas pesquisas descrevem informações sobre o efeito, a influência, a eficiência agronômica e a viabilidade econômica, na qualidade de mudas da cultura do tomate. Objetivou-se com esta pesquisa estudar o efeito de diferentes doses de biofertilizante à base de algas marinhas Ascophyllum nodosum aplicado em fertirrigação no desenvolvimento de plântulas de tomate cultivar Bartô. Realizou-se uma pesquisa experimental em campo e, de natureza quantitativa, na qual se utilizou um delineamento inteiramente casualizado, com quatro tratamentos (dose de biofertilizante em fertirrigação: 0 ml L-1, 3 ml L-1, 6 ml L-1 e 9 ml L-1) e quatro repetições. Cada parcela foi representada por 10 plantas de tomate da cultivar Bartô (Feltrin®). Foram avaliadas as seguintes características: número de folhas, altura de plântulas, diâmetro de caule, comprimento de raiz, massa fresca da parte aérea e massa fresca do sistema radicular. Nas condições do experimento, a aplicação do extrato de algas marinhas Ascophyllum nodosum (L.) em suas diferentes concentrações não influenciou significativamente o desenvolvimento de plântulas de tomate para a variedade avaliada não constatada uma melhor dose.
Assessment of the results of treatment of patients with cervical rib syndrome in the postoperative period
Authors:   Republican Scientific Center of Cardiovascular Surgery of the Ministry of Health and Social Protection of the population of the Republic of Tajikistan, Rafiev F. R.
Published: September 2024

The pectoral exit syndrome is of undoubted interest for surgeons, angiosurgeons and neurologists due to the possible compression of the vascular-nervous plexus, causing certain symptoms and reducing work abilities. Objective To conduct an analysis of the results of the treatment of patients with cervical rib syndrome in the short and remote observation periods in the postoperative period. Material and methods 138 patients with abnormal cervical ribs were the clinical material and the object for the study, abnormal cervical ribs caused the extravasal compression of the vascular bunch of the upper extremities at the exit from the chest. These patients were treated and were operated on in the vascular surgery department of the Republican Scientific Center of Cardiovascular Surgery from January 1990 to May 2020. Results Good postoperative results were observed in 89.1 % of patients in the short postoperative period. Intraoperative complications were noted in 5 (3.6 %), and in the short postoperative period – in 10 (7.2 %) patients. In the remote period, relapse of preoperative symptoms of the disease was noted in 8 (5.8 %) of all 138 patients observed. Relapse (or renewal of the symptoms of Reino) was mainly observed in the period of up to 3 years. At different times of observation, 5 patients were lost from sight. In the remote period, in terms of up to 1 year of observation, a good result was 97.2 %, from 2–3 years to more than 5 years – 90.6 %. Conclusions The early identification of intraoperative and postoperative complications allows to timely eliminate these complications. In the nearest postoperative period, only the hemodynamic effect of decompression operations and selective cervical-breed sympathctomy is obvious. Neurological symptoms regressed gradually in the remote period. In this case, it is necessary to emphasize the importance of timely rehabilitation therapy, the implementation of the recommendations of a specialist, since the restoration of dystrophic changes in the nerve trunks is a long process.
Current trends in reproductive losses in Khabarovsk Krai
Authors:   Postgraduate Institute for Public Health Workers of the Ministry of Health of the Khabarovsk Krai, Khabarovsk, Russia, Korablev V.N. , Kolesnikova S.M. ,   Postgraduate Institute for Public Health Workers of the Ministry of Health of the Khabarovsk Krai, Khabarovsk, Russia, Chizhova G.V. ,   Postgraduate Institute for Public Health Workers of the Ministry of Health of the Khabarovsk Krai, Khabarovsk, Russia
Published: September 2024

Abstract The relevance of the problem. Demographic processes are an urgent problem for the Far East and the Khabarovsk Krai. The objective of this study was to examine current trends in reproductive losses in Khabarovsk Krai in comparison with data for the Russian Federation and the Far Eastern Federal District. Material and research methods. The comparative analysis method is used in the article. The source of information was publications in Russian scientific journals and monographs, the data obtained from the official web sites of Rossstat of the Russian Federation and the Khabarovsk Krai, as well as statistical materials published by the Medical Information and Analytical Center of the Ministry of Health of the Khabarovsk Krai for 2019–2022. For the period of preparation of the material, the data of Russia's Rosstat for 2023 on maternal and infant mortality in the official access was not available. Results and discussion. A comparative analysis of maternal, perinatal and infant mortality, as well as stillbirth in the context of federal districts, subjects of the Far Eastern Federal District and the Khabarovsk Krai in 2019–2022 has shown that in all 4 indicators the most disadvantaged in the Russian Federation are the Siberian and Far Eastern Federal Districts, as well as the North-West Federal District (except for the infant mortality rate). In the Far Eastern Federal District, the most disadvantaged subjects in terms of all indicators were the Chukotka Autonomous Okrug, the Jewish Autonomous Oblast and the Trans -Baikal Territory, as well as the Kamchatka Oblast (with the exception of an indicator of stillbirth). The Khabarovsk Krai in all aspects has got the middle position. In the Khabarovsk Krai, special attention is required in terms of stillborn and perinatal mortality of Okhotsk and Nikolaevsky-on-Amur municipal areas. Conclusions. The study of reproductive losses in Khabarovsk Krai allows us to determine the risks and priorities for the development of demographic processes. The analysis has shown that the region took a middle position in terms of maternal, perinatal and infant mortality rates in 2019–2022 compared to data for the Russian Federation and the Far Eastern Federal District. At the same time, during the study period, there was a sharp increase in maternal mortality from 6.93 cases in 2019 to 15.5 cases in 2022 per 100,000 births, which indicates the insufficient effectiveness of health authorities and medical organizations in preventing it.
Medico-demographic situation in the Arctic area of Sakha (Yakutia) for the period of 2000–2022 years
Authors:   Medical Institute of M. K. Ammosov North-East Federal University, Timofeev L. F. , Savvina N. V. ,   Medical Institute of M. K. Ammosov North-East Federal University, Timofeev A. L. ,   Medical Institute of M. K. Ammosov North-East Federal University
Published: September 2024

Relevance. Scientific studies have revealed problems in health condition of the population of the Russian Federation, living in the Arctic zone of the Russian Federation, thus the state support of the Arctic regions of the country is needed. Such a support is based not only on economic interests but on the issues of development of human potential as well. Objective. Analysis of the dynamics of medical and demographic processes in the Arctic zone of the Republic of Sakha (Yakutia) for the period of 2000–2022. Materials and methods. Initially, on the basis of data from the FSGS of the RS (Y) and YARMIAC, the situation for all administrative- territorial subjects (districts/uluses) of the republic was calculated by the percentile method. According to this method, the uluses with indicators of up to the 10 percintiles were related to territories with a low level of one or another indicator, from 10 to the 25th persentiles -with a level below the average, from 75 to 90th-above the average and over 90th and over 90 Persentiles - with a high level. Obviously, with indicators lying between the 25th to the 75th persentiles, the uluses belonged to the group with average values. Then the indicated uluses included in the Arctic zone were allocated in a separate group for further analysis. Results. It turned out that if there is no unequivocal final assessment in the group and EPN, then 5–6 uluses of mortality and infant mortality notes their relatively high levels as a whole for a 23-year period. Conclusions. If the fertility has uluses with both relatively high and relatively low levels of this indicator, then 5 uluses already have relatively high levels of mortality rate when compared with all uluses of the republic. In addition, 6 uluses have relatively high levels of infant mortality. According to EPN, the picture also seems ambiguous.
Health status of datained adolescents, according to the data of 2019–2023
Authors:   Postgraduate Institute for Public Health Workers of the Ministry of Health of the Khabarovsk Krai, Khabarovsk, Russia, Yakhieva-Onikhimovskaya D. A. , Kolesnikova S.M. ,   Postgraduate Institute for Public Health Workers of the Ministry of Health of the Khabarovsk Krai, Khabarovsk, Russia
Published: September 2024

The problem of the health of adolescents causes a special concern of the state, since they constitute a reserve of human resources in the socio-economic development of the country. The existing negative phenomena in a teenage environment, especially in people who are in custody, have an impact on their health. The study of the characteristics of the health status of adolescents in places of imprisonment will contribute to the development of recommendations aimed at maintaining their health, the possibility of their future adaptation in society. Objective. To study and summarize the health data of adolescents detained, and to identify the most characteristic of this group of children's population. Material and methods. This clinical observational non-finished cross-sectional study was conducted from November 2019 to November 2023 (5 full years) on the basis of the Temporary detention center of minor offenders of the Russian Ministry of Interior in the Khabarovsk Krai. 470 people have participated in the. Results. The detained adolescents had poor health indicators against the backdrop of a rooted unfavorable socio-economic situation: among children of the studied group, infectious diseases and parasitosis, mental disorders, trophic hypostature and protein- energy deficiency, the consequences of propmiscitable behavior and alcoholization, the lack of basic knowledge about about the consequences of the base and alcoholization were reliably more common. Self-and mutual assistance, hygiene standards, nutritional rules and a healthy lifestyle. Conclusions. An increase in investment for a regular comprehensive examination of all adolescents in custody, in combination with scientifically based treatment in places of imprisonment will help reduce the burden of preventive diseases among these young people and increase the possibility of their adaptation in society upon release.
EVALUATION OF IT GOVERNANCE USING COBIT 2019 ON REGIONAL ASSET MANAGEMENT AGENCY OF DKI JAKARTA
Authors: Herliani Meidina , Wella Wella
Published: September 2024

An adequate level of IT availability can obtained by implementing IT Governance, which pay attention to all related issues service readiness, including services and resources. This research aimed to assess the IT Governance capability at the Regional Asset Management Agency (BPAD), a government institution responsible for asset management. The study specifically focused on issues related to data and information management, including leadership and risk management challenges. Using the COBIT 2019 Framework, data were collected through interviews and observations. The respondent of this research are 4 who work in the Data and Information Sub-Sector and one Head of Asset Administration. The findings revealed that the EDM 05 process achieved a capability level of 4, surpassing the organization's target. However, the APO 08 and APO 12 processes were rated at level 2, highlighting areas in need of improvement. The study provides recommendations to enhance BPAD's performance and optimize its business activities.
CLASSIFICATION OF HEART DISEASE USING THE K-NEAREST NEIGHBOR ALGORITHM AND LOGISTIC REGRESSION
Authors: Sugitha I Kadek Agga , Triayudi Agung , Handayani Endah Tri Esti
Published: September 2024

Heart disease is a major cause of death in the world, including in Indonesia, with increasing rates and death rates that carry a huge burden on health and society. Lack of awareness of early signs contributes significantly to this challenge. This study aims to prevent heart disease through early diagnosis using K-Nearest Neighbor (K-NN) and Logistic Regression algorithms. The database, obtained from Kaggle.com, includes 15 clinical units for cardiac diagnosis. The test shows that the K-NN method with k = 3 achieves the highest performance on the experimental data (30%), with 90% precision, 93% precision, 87% recall, and 90% f1 - score. In comparison, Logistic Regression and sigmoid achieved 86% precision, 83% precision, 90% recall, and 86% f1-score on the same experimental data. These results show that K-Nearest Neighbor is better than Logistic Regression as a classification algorithm for heart disease database. Applying these findings to the web-based Streamlit system is expected to improve the efficiency and timeliness of heart disease screening.
A Rare Case of Occupational Aniline Poisoning: Management in a Limited-Facility Setting
Authors: Niroomand Behnaz , Mohammadzadeh Ibrahim , Rahimi Mitra , Bijandi Mohsen
Published: September 2024

Introduction
Cyanosis along with altered mental should bring all the possible ethiologies into her mind in a minimum of time, based on the trauma, medical, environmental, and occupational history of the patient. Poisoning with methemoglobinemia inducing agents is one of the most important differentials especially when a history of occupational exposure to these agents is present.
Case Report
The patient, a 41-year-old healthy woman and engineer, experienced symptoms after exposure to aniline leading to dizziness and weakness, prompting a visit to the emergency department with cyanosis and low oxygen saturation. Initial vital signs showed decreased oxygen levels and elevated respiratory rate with normal ABG values despite ongoing cyanosis. Patient required intubation, mechanical ventilation, and was diagnosed with ARDS based on chest X-ray findings. Management included IV diuretics, 100% oxygen, and antioxidant treatment in the ICU. Despite treatment, oxygen saturation remained at 88% on the first day.
Conclusion
This case is a reminder of the importance of taking occupational history and management of aniline toxicity in a setting where methylene blue, the drug of choice for aniline toxicity, is not available in the drug stock.
Heavy Metal Distributions of Macroalgal Species From the Mersin Inner Bay, Türkiye
Authors: Özbay Özgür , Akçay İsmail
Published: September 2024

The bio-accumulation of heavy metals in macroalgae poses significant risks to marine ecosystems and human health. In this study, heavy metal distributions of macroalgae and potential health risk assessment in the Mersin inner Bay were determined from macroalgae (Stypopodium schimperi, Padina pavonica, Laurencia obtusa, Dictyota sp., Sargassum vulgare, Jania rubens, Halopithys sp., Osmundea sp., Halopithys incurve, Ulva intestinalis, Entromorpha flexuosa, Ulva linza) samples collected between February and September 2021. The levels of heavy metals were found as 1.24-5.93 g/kg for aluminum, 0.61-5.26 g/kg for iron, 1.17-7.61 mg/kg for cobalt, 0.03-0.21 mg/kg for cadmium, 4.26-43.10 mg/kg for chromium, 0.28-437.52 mg/kg for cupper, 17.90-139.08 mg/kg for manganese, 2.78-79.25 mg/kg for nickel, 0.75-3.49 mg/kg for lead and 1.71-70.34 mg/kg for zinc, respectively. The potential risk assessment of macroalgal species using the calculated total cancer risk (TCR) suggested high carcinogenic risk from the carcinogenic chromium, copper and nickel (TCR>1.00E-04).
Temporal Volatility of Brent Oil Prices and Interrelation With Maritime Traffic Density in the Turkish Straits During COVID-19 Crisis
Authors: Yiğit Ümüt
Published: September 2024

This research evaluated variations in Brent oil prices and the interrelation with maritime traffic density in the Turkish Straits during the COVID-19 pandemic. The number of commercial ships that made non-stop over passage through the Turkish Straits in the last 5 years, covering the COVID-19 -and post-pandemic periods with economic instabilities was investigated along with variables of vessel characteristics such as; gross tonnage, size and type of vessel loads. Results of the present study reveal that the maritime traffic density between 2019 and 2023, was influenced by the pandemic crisis, when harsh quarantine measures of lockdown and curfews in the first shock wave. In the aftermath, conflicts between Ukraine and Russia led to economic recession or upheaval with instabilities in Brent oil prices. For the period examined in this study, the number of non-stop over passage vessels and gross tonnages used the Turkish Straits were affected by the pandemic outbreak and Brent oil price variations. The number of vessels decreased by 5.22% from 84,871 to 80,440 during the epidemic in 2020, and by 5.38% from 43.342 to 42.340 during the global recession in 2022. Overall, the number of non-stop over passage vessels using the Turkish Straits between 2019 and 2023 declined by 1.15%, while the gross tonnage and ship length increased by 3.44% and 13.24%, respectively. In total, the number of non-specific tankers (TTA) and those carrying chemicals (TCH) increased by 2.92% and 10.97%, respectively, but a 13.25% decrease was noted for the liquefied petroleum gas (LPG) tankers over the 5 years. Considering that the world trade network is largely dependent on maritime transportation, identifying the changes in maritime transportation with the interrelation of Brent oil during global crises may provide important data for strategy building of best trade management with foresights to world economic crises.
PARKİNSON HASTALARINDA HASTALIĞA ÖZGÜ YAŞAM KALİTESİNİ BELİRLEYEN MOTOR SEMPTOMLAR
Authors: Yaşa Mustafa Ertuğrul , Sonkaya Rıza , Korkmaz Buse , Fındık Büşra Nur , Yaşar Şeyma , Öztürk Bilgin , Karadaş Ömer
Published: September 2024

Toplumların yaşlanması ve hazırlayıcı faktörlerin artmasıyla yakın gelecekte bir Parkinson pandemisi beklenmektedir. Bu durum Parkinson hastalığının etkilerini daha çok araştırmayı gerekli kılmaktadır. Bu çalışma Türk toplumunda yaşayan Parkinson hastalarından oluşmuş bir grup üzerinde hastalığa özgü yaşam kalitesini belirleyen motor semptomların araştırılması amacıyla planlanmıştır. Hastaların motor fonksiyonları Birleşik Parkinson Hastalığı Derecelendirme Ölçeği’nin 3. Bölümü ile, üst ekstremite fonksiyonları 9-delikli peg test (9DPT) ile, yaşam kalitesi Parkinson Hastalığı Yaşam Kalitesi Ölçeği – Kısa Form (PDQ-8) ile değerlendirildi. Hangi motor semptom değişkeninin yaşam kalitesi puanına en çok katkı sağladığı geriye doğru doğrusal regresyon analizi ile incelendi. Çalışma ortalama yaşları 64,43±9,67 (yıl) olan 100 idiopatik Parkinson hastası (49 kadın, 51 erkek) ile tamamlandı. 9DPT tamamlama süresinin (p
Collatz Sequence
Authors: Muhammad Taha
Published: September 2024

Abstract of Solving Collatz Sequence I started from a loop containing all positive numbers and performed Collatz law on each number x in the loop, obtained algebraic equations, and defined the values of x, which not belong to the set of natural numbers except 1. Then I applied Collatz laws and obtained the elements of the loop, which are {4, 2, 1}. S (n)= {n/2 or 3n+1, ..., 4,2,1} for all N+. Thus LS (n) = {4,2,1} for all N+. I added extra work to support my proof: 1- Graph 2- Sketch 3- Chart 4- Table 5- Pattern 5- [If LS (n)= {4,2,1} for r = 3k] True Then I proved that [LS (n) = {4, 2, 1} for r+3= 3(k+1)] True 6- [If LS (n) has no loop if for r = 3k+h, h<3, h is a natural number] True Then I proved that [LS (n) has no loop if for r+1 = 3k+h+1=3k+2, h=1] True Therefore: LS (5) = LS (10^100) = LS ((10^1000) + 7) = LS (47) = ... = LS (1) = {4, 2, 1} only for all n in N+ Note: r = # of elements in a loop. K = 1 or 2
ON TOPICAL PROBLEMS OF THE MODERN SCHOOL: TEACHERS’ OPINION IN THE KOSTROMA REGION
Authors: Belova Natalia A. 
Published: September 2024

This article presents the findings of a survey among school teachers conducted in Kostroma between April and May 2024. The objective of the study was to ascertain the level of satisfaction with their profession among teachers and to identify the most significant challenges they face in their work. The concerns expressed by the respondents could be grouped into the following categories: low income and low salaries, excessive teaching workload and a lack of free time; insufficient material and technical resources in schools in the region; and weak moral incentives for teachers. The results of the survey indicate that, in addition to financial concerns, teachers are also dissatisfied with the decline in their authority and status within society. Furthermore, the survey demonstrated that the material aspect is a significant but not a primary source of discontent among teachers. Their social status, which does not align with their qualifications, is a notable concern. It is also important that in underprivileged regions, the shortage of personnel has intensified, particularly in mathematics and the Russian language. Based on statistical data, media reports, and field observations, there seems to be a reluctance among young individuals to pursue careers in education. The teachers who participated in the survey reached a unanimous consensus on the necessity of implementing measures to enhance the material well-being of educators, upgrade the material and technical infrastructure of educational institutions, and reinstate the esteemed status of teaching professionals in society.
A dynamically loaded ex vivo model to study neocartilage and integration in human cartilage repair
Authors: Trengove Anna , Caballero Aguilar Lilith M. , Di Bella Claudia , Onofrillo Carmine , Duchi Serena , O’Connor Andrea J.
Published: September 2024

Articular cartilage injuries in the knee can lead to post-traumatic osteoarthritis if untreated, causing debilitating problems later in life. Standard surgical treatments fail to ensure long lasting repair of damaged cartilage, often resulting in fibrotic tissue. While there is a vast amount of research into cartilage regeneration, integrating engineered implants with cartilage remains a challenge. As cartilage is a load bearing tissue, it is imperative to evaluate tissue repair strategies and their ability to integrate under mechanical loading. This work established a dynamically loaded ex vivo model of cartilage repair using human cartilage explants. The model was used to assess the efficacy of a stem cell therapy delivered in a bioadhesive hydrogel comprised of photocrosslinkable gelatin methacryloyl (GelMA) and microbial transglutaminase to repair the model defect. Extensive neocartilage production and integration were observed via histology and immunohistochemistry after 28 days chondrogenic culture. Analysis of culture media allowed monitoring of glycosaminoglycan and type II collagen production over time. A mechanical assessment of integration via a push out test showed a 15-fold increase in push out strength over the culture duration. The model was successful in exhibiting robust chondrogenesis with transglutaminase or without, and under both culture conditions. The work also highlights several limitations of ex vivo models and challenges of working with bioreactors that must be overcome to increase their utility. This ex vivo model has the potential to delay the need for costly pre-clinical studies and provide a more nuanced assessment of cartilage repair strategies than is possible in vivo.
Targeting caspase-8/c-FLIPL heterodimer in complex II promotes DL-mediated cell death
Authors: Hillert-Richter Laura K. , König Corinna , Ivanisenko Nikita V. , Reinhold Dirk , Lavrik Inna N.
Published: September 2024

Death receptor (DR) networks are controlled by the assembly of the Death-Inducing Signaling Complex (DISC) and complex II. The family of small molecules FLIPins (FLIP interactors) were developed to target the caspase-8/c-FLIPL heterodimer. FLIPin compounds were shown to promote apoptosis and caspase-8 activation at the DISC upon stimulation with death ligands (DLs) such as CD95L and TRAIL. To further investigate the role of FLIPin compounds in the DL-mediated cell death response, we analyzed their effects in combination with DLs and SMAC mimetics treatment. FLIPins were found to enhance cell viability loss and cell death induced by DL and SMAC mimetics in acute myeloid leukemia (AML), colon and pancreatic cancer cells. FLIPins enhanced both DL/BV6-induced apoptosis and DL/BV6/zVAD-fmk-induced necroptosis via an increase in complex II formation. Our results indicate that targeting the caspase-8/c-FLIPL heterodimer plays a prominent role in enhancing cell death induced by co-stimulation of DL/SMAC mimetics and opens new therapeutic strategies for targeting DR networks.
Linking DNA damage and senescence to gestation period and lifespan in placental mammals
Authors: Singh Vijay Pratap , Singh Pushpendra
Published: September 2024

The mechanism that synchronizes the timing of parturition remains a mystery. Each mammalian species has a specific duration of gestation that is determined by integrated interactions among the mother, placenta, and fetus. Senescence is primarily driven by DNA damage and is one of the critical factors influencing both parturition and lifespan. In this study, we investigated senescence as a physiological process during pregnancy and observed a gradual physiological increase in senescence in the maternal decidua and placental cells with gestation. This increase in senescence was associated with a gradual physiological increase in DNA damage during gestation. An analysis of the AnAge dataset revealed a positive correlation between the gestation period and maximum lifespan across 740 mammalian species. This finding supports the hypothesis that the rates of DNA damage and senescence may impact both the gestation period and lifespan. We suggest that the relationship between gestation period and lifespan in mammals is mediated by species-specific rates of DNA damage and senescence, necessitating further explorations into their causal roles.
Synthesis of the modified SBA-15 mesoporous silica with TAN ligand to preconcentrate and determine trace amounts of Ni (II) ions in water and wastewater samples
Authors: Amouzad Mahdirajeh Taha , Mirabi Ali , Habibi Juybari Mohammad , Zafar Mehrabian Ramin , Jalilian Hamid Reza
Published: September 2024

The synthesis of modified mesoporous silica (SBA-15), a powerful and highly effective adsorbent, was provided for the preconcentration, extraction, separation, and determination of trace amounts of Ni (II) ions. In this method, SBA-15 modified with 1-(2-thiazolylazo)-2-naphthol (TAN) was used as a suitable absorbent. The absorption of Ni (II) ions was studied using the FAAS technique. Transmission electron microscopy (TEM), thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET), energy-dispersive spectroscopy (EDS), Fourier-transform infrared (FT-IR) spectroscopy, and CHNS elemental analysis techniques were used to assess the characteristics of SBA-15 and TAN/SBA-15. Effective parameters (pH, amount of nanocomposite, extraction time, and type of recovery solvent) for extracting Ni (II) ions via TAN/SBA-15 were investigated. The merit figures of the method were obtained with appropriate results, such as detection limit, accuracy, enrichment factor, and preconcentration factor. The calibration curve was linear within the range of 5.0–50 ng mL-1 with a detection limit of 1.8 ng mL-1. High preconcentration, small relative standard deviations, and enrichment factors (approximately 100) were represented by the statistical analysis. The proposed method for measuring Ni (II) ions was used at trace levels in real samples, such as seawater, river water, well water, and wastewater from a textile factory, an electrical power station, an MDF factory, and a food industrial company, with satisfactory results.
Risk factors and predictive model for nosocomial infections by extensively drug-resistant Acinetobacter baumannii
Authors: Shi Jingchao , Mao Xiaoting , Cheng Jianghao , Shao Lijia , Shan Xiaoyun , Zhu Yijun
Published: September 2024

Background

Extensively drug-resistant Acinetobacter baumannii (XDRAB) has become a significant pathogen in hospital environments, particularly in intensive care units (ICUs). XDRAB’s resistance to conventional antimicrobial treatments and ability to survive on various surfaces pose a substantial threat to patient health, often resulting in severe infections such as ventilator-associated pneumonia (VAP) and bloodstream infections (BSI).

Methods

We retrospectively analyzed clinical data from 559 patients with XDRAB infections admitted to Jinhua Central Hospital between January 2021 and December 2023. Patients were randomly divided into a training set (391 cases) and a testing set (168 cases). Variables were selected using Lasso regression and logistic regression analysis, and a predictive model was constructed and validated internally and externally. Model performance and clinical utility were evaluated using the Hosmer-Lemeshow test, C-index, ROC curve, decision curve analysis (DCA), and clinical impact curve (CIC).

Results

Lasso regression analysis was used to screen 35 variables, selecting features through 10-fold cross-validation. We chose lambda.1se=0.03450 (log(lambda.1se)=-3.367), including 10 non-zero coefficient features. These features were then included in a multivariate logistic regression analysis, identifying 8 independent risk factors for XDRAB infection: ICU stay of 1-7 days (OR=3.970, 95%CI=1.586-9.937), ICU stay >7 days (OR=12.316, 95%CI=5.661-26.793), hypoproteinemia (OR=3.249, 95%CI=1.679-6.291), glucocorticoid use (OR=2.371, 95%CI=1.231-4.564), urinary catheterization (OR=2.148, 95%CI=1.120-4.120), mechanical ventilation (OR=2.737, 95%CI=1.367-5.482), diabetes mellitus (OR=2.435, 95%CI=1.050-5.646), carbapenem use (OR=6.649, 95%CI=2.321-19.048), and β-lactamase inhibitor use (OR=4.146, 95%CI=2.145-8.014). These 8 factors were used to construct a predictive model visualized through a nomogram. The model validation showed a C-index of 0.932 for the training set and 0.929 for the testing set, with a Hosmer-Lemeshow test p-value of 0.47, indicating good calibration. Furthermore, the DCA curve demonstrated good clinical decision-making performance, and the CIC curve confirmed the model’s reliable clinical impact.

Conclusion

Regression analysis identified ICU stay duration, hypoproteinemia, glucocorticoid use, urinary catheterization, mechanical ventilation, diabetes mellitus, carbapenem use, and β-lactamase inhibitor use as independent risk factors for XDRAB infection. The corresponding predictive model demonstrated high accuracy and stability.
Care manager role for older multimorbid heart failure patients’ needs in relation to psychological distress and quality of life: a cross-sectional study
Authors: Gostoli Sara , Subach Regina , Guolo Francesco , Bernardini Francesco , Cammarata Alessandra , Gigante Graziano , Herbeck Belnap Birgit , Della Riva Diego , Urbinati Stefano , Rafanelli Chiara
Published: September 2024

Background

There are few studies investigating patients’ needs in healthcare focusing on disease severity and psychological characteristics of elderly heart failure (HF) patients with multimorbidity, specifically addressed by a care manager (CM).

Aims

To explore the role of a CM dealing with elderly multimorbid HF patients’ needs/preferences according to NYHA class, ejection fraction, psychological/psychosomatic distress and quality of life (QoL), utilizing a Blended Collaborative Care (BCC) approach (ESCAPE; Grant agreement No 945377).

Methods

Cue cards, self-reported questionnaires, and a semi-structured interview were used to collect data.

Results

Twenty-five Italian patients (mean age ± SD = 77.5 ± 6.68) were enrolled between June 2021 and March 2022. The most relevant patients’ needs to be addressed by a CM were: education (e.g., on medical comorbidities), individual treatment tailoring (e.g., higher number of appointments with cardiologists) and symptom monitoring.

Conclusion

The study highlights the importance of targeting HF patients’ needs according to psychological characteristics, whose healthcare requires person-centered care with CM assistance. In view of ESCAPE BCC intervention, a CM should consider specific patients’ needs of elderly multimorbid HF patients with psychological, psychosomatic distress, particularly somatization, and lower QoL to achieve a more personalized health care pathway.

Study registration

The «Evaluation of a patient-centred biopsychosocial blended collaborative care pathway for the treatment of multi-morbid elderly patients» (ESCAPE) study has been registered at the University of Göttingen Medical Centre (UMG Reg. No 02853) and the German Clinical Trials Register (DRKS00025120).
The geodynamics of plume-influenced mid-ocean ridges: insights from the Foundation Segment of the Pacific-Antarctic Ridge
Authors: Brandl Philipp A. , Beier Christoph , Haase Karsten M. , Genske Felix S. , Hauff Folkmar , Regelous Marcel , Devey Colin W. , Rüpke Lars H.
Published: September 2024

The intersection of the Foundation Plume with the Pacific-Antarctic Ridge is a key location in global geodynamics where a mantle plume is approached by and interacting with a fast-spreading mid-ocean ridge. Here, we discuss a comprehensive major and trace element and Sr-Nd-Pb isotope dataset of new and existing samples from the young Foundation Seamount Chain (<5 Ma) and adjacent section of the Pacific-Antarctic Ridge. We use the geochemistry of axial, off-axis and intraplate lavas to map the spatial extent of plume dispersal underneath the ridge as well as the internal zonation of the upwelling plume. We show that the unusual length, increased crustal thickness and occurrence of silicic rocks on the axis of the Foundation Segment are the direct result of plume being tapped by the axial melting zone. We demonstrate that the plume is not homogeneous but shows a HIMU-like (high time-integrated 238U/204Pb) OIB (Ocean Island Basalt) component characterized by 206Pb/204Pb of up to 20.5 in its center and a more EM1-like (Enriched Mantle one) OIB component characterized by low U/Pb and 206Pb/204Pb but high Rb/Nb and 87Sr/86Sr towards its edges. Plume entrainment leads to a high magma supply rate that fosters the formation of silicic rocks and triggers the lengthening of the segment over time. However, plume dispersal is not symmetric as the geochemical tracers for the OIB component are extending <100 km northwards but >300 km southwards. We relate this to the current plate tectonic framework in which the obliquity between the migrating ridge and the absolute plate motions induces a sub-axial asthenospheric flow that preferentially channels plume material southwards.
Effect of sodium dodecyl sulphate on the rheological and carbon sequestration properties of cemented paste backfill with CO2 injection
Authors: Shen Zhuo , Zhou Yibo
Published: September 2024

Cemented paste backfill (CPB) is a technology that has a positive impact on both the environment and mining safety. In recent years, it has been widely applied and developed. To improve the carbon sequestration efficiency of CPB, air-entraining agent addition to CO2-injected CPB (CO2-CPB) has been proposed. However, the influence of air-entraining agents on the rheological and carbon sequestration properties of CO2-CPB has not been investigated to date. Therefore, sodium dodecyl sulphate (SDS), an air-entraining agent, was selected in this study, and the rheological and carbon sequestration properties of CO2-CPB added with SDS were comprehensively investigated. CO2-CPB samples with 0.0‰, 0.5‰, 1.0‰, and 1.5‰ SDS were prepared, and the rheological parameters (yield stress and viscosity) were tested after curing for 0, 0.25, 1, and 2 h. Gas content testing, microscopic analysis, and zeta potential measurements were performed. The results show that SDS addition decreased the yield stress and viscosity of CO2-CPB at 0–1 h; however, the yield stress and viscosity increased at 2 h. SDS addition significantly improved the carbon sequestration performance of CO2-CPB. The findings of this study have important implications for carbon sequestration development in CPB and solid waste utilisation.