bluuebunny/crossref_metadata_2025 huggingface dataset:
Influencing factors on bone mass abnormalities in Tibetan adult females from a socioeconomic perspective
Authors: ZHONG Huaichang , ZHOU Yaxi , WANG Peng , JIA Qundi , WAN yang , WANG Wenzhi , XIONG hai
Published: October 2023

Background Social economy is an important factor affecting human bone health. The higher prevalence of abnormal bone mass in Tibetan female adults with lower socioeconomic status may be attributed to lower health service utilization and unhealthy lifestyle behaviors. To explore the current status and influencing factors of bone mass abnormalities in Tibetan adult women from a socio- economic perspective, in order to provide a reference for the prevention and treatment of bone mass abnormalities in local Tibetan adult women.
Methods A total of 640 Tibetan adult females were randomly selected from six counties including Gaize County by multi-stage stratified random sampling method. The c2 test and multivariate logistic regression method were used to analyze the current status of bone mass abnormalities and its influencing factors in Tibetan adult women.
Results Among 640 Tibetan adult females, 499 cases (78.0%) had normal bone mineral density and 141 cases (22.0%) were in the abnormal bone mass group. Last year's household income level, last year's medical expenditure level, literacy level, and stroke were the influencing factors for abnormal bone mass.
Conclusion Socioeconomic status is an important influencing factor of bone mass abnormalities in Tibetan adult females. Higher family income and higher education level are protective factors for bone mass abnormalities, and higher medical expenditure and suffering from stroke are risk factors for bone mass abnormalities. Efforts should be continued to narrow the gap between rich and poor in society, increase the access and ability of women with lower socioeconomic status to health education and medical services, improve their quality of life, and strive to achieve the goal of health for all.
Application of detergent as carbon sources for polyhydroxyalkanoate accumulation by Bacillus spp.
Authors: Chou Hung‑Che , Chen Chia‑Hsin , Huang Chun‑Mei , Wang Hui‑Jun , Hsiung Yu‑Chuan , Ou Chung‑Mao , Guo Gia‑Luen
Published: October 2023

This study investigated the potential of various detergents as carbon substrates for polyhydroxyalkanoate (PHA) production under nitrogen-limited conditions. We determined that Tween 80 promoted PHA accumulation by ZD-F1, a Bacillus sp. strain isolated from field sludge. When cultured with Tween 80, ZD-F1 achieved a peak dry cell weight (DCW) of 3.28 g/L, along with a PHA content of 18.96% and PHA yield of 0.48 g/L. Tween 80 at various concentrations resulted in a PHA theoretical yield of 0–10.6%. Experiments assessing the PHA species indicated that the PHA species under both Tween 80 and glucose was 3HB. Moreover, through chemical and biochemical stoichiometric calculations, we determined that the theoretical yields of 3HB from Tween 80 were 1.228 and 0.558 g/g, respectively, and those of 3HB from glucose were 0.716 and 0.318–0.477 g/g, respectively, across various catabolic pathways. To our knowledge, this is the first study to analyze PHA accumulation by a Bacillus sp. strain—isolated from wastewater treatment plant sludge—under various detergents as carbon sources.
Radiographic Evaluation of Pulmonary Embolus Study at Mouwasat University Hospita On the Radiological Signs of pulmonary embolus On plain chest images and CT scans.
Authors: Aldahouk Yara , khattab Khalid
Published: October 2023

Pulmonary embolism results from an emboli in any part of the pulmonary circulation, it is usually caused by avenous thrombosis in the deep veins, Risk factors for pulmonary embolism include three basic forms called Virchow triad: Vascular trauma, Increased coagulability, Reduced blood flow, The clinical manifestations of pulmonary embolism are nonspecific, but their presence with one of the risk factors leads to pulmonary embolism, and then we carry out appropriate investigations and measures, Plain chest X-ray is often non directional and is used to ruleout symptoms clinically similar to pulmonary embolus, Pulmonary angiography is currently considered the gold standard for diagnosis, It is often performed using the multishider technique, wich has asensitivity and specificity equal to contrast angiography, but it is a non – invasive procedure and is therefore more widely used
Meteorological Characteristics of a Continuous Ice-covered Event on Ultra-High Voltage Transmission Lines in Yunnan Region in 2021
Authors: He Sen , Song Yunhai , Huang Heyan , He Yuhao , Zhou Shaohui , Gao Zhiqiu
Published: October 2023

Yunnan plays a pivotal role in transmitting electricity from west to east within China's Southern Power Grid. During January 7-13, 2021, a large-scale continuous ice-covering event of ultra-high voltage (UHV) transmission lines occurred in Qujing area in eastern Yunnan Province. Based on ERA5 reanalysis data and meteorological observation data of UHV transmission line icing in China Southern Power Grid, the synoptic causes of the icing are analyzed comprehensively from the aspects of weather situation, vertical stratification of temperature and humidity, local meteorological elements, and atmospheric circulation indices. The results show that the East Asian trough is strong, and the blocking high leads the northern air flow in front of the ridge to the south, and the cold air enters the ridge and joins the warm and wet air brought by the subtropical high pressure of 50-90°E. When the warm and cold air masses confront each other to form a quasi-stationary front over the northern mountains of Qujing, the alternating dominance of the warm and cold air is the main reason for the repeated ice accumulation of the power lines. Indices such as the Siberian High, East Asian Trough, and 50-90 ° E Subtropical High provided clear precursor signals within 0-2 days in advance of the icing events.
Evaluation of Sugar Content and Bioethanol Production of Ethiopian Local Varieties “Nech Tinkish” and “Hawaye”Sweet Sorghum (Sorghum Bicolor (L.)
Authors: Kasegn Melaku Mekonen , Simachew Addis , Redda Yisehak Tsegaye , Gebremedhn Hailay Mehari , Berhanu Addisu Desalegn , Mossa Mohammed Mebrahtu
Published: October 2023

Diversifying the use of climate-smart crops such as Sweet sorghum has the potential to solve integrated food, bioenergy, feed, and land management problems. The study purposed to quantify the sugar content of Nech Tinkish (v1) and Hawaye (v2) indigenous sweet sorghum varieties and investigate the interaction effect of fermentation parameters to determine their capacity for ethanol production. Sweet sorghum varieties were analyzed to determine their difference in oBrix content by extracting their juices. The juice was clarified using milk lime. Its total soluble sugars, total carbohydrates, and reducing sugars were determined using a digital Refractometer, phenol sulfuric acid, and 3, 5-Dinitro salicylic acid, respectively. A completely Randomized Factorial was employed to evaluate ethanol production capacity, and the ethanol content was estimated using a potassium dichromate solution. The oBrix results revealed that v2 had a higher sugar concentration than v1. Additionally, the estimated carbohydrate content of the juice ranged from 37.402 g/L to 157.641 g/L. The estimated reducing sugar also varied from 4.644 g/L to 33.412 g/L. Therefore, the estimated reducing sugar showed the hydrolysis of Sweet sorghum juice by invertase and sulfuric acid produced more fermentable sugars. Fermentation at 30 oC with pH 4.5 incubated for four days yields the highest ethanol, and v2 yields higher (15.31%) ethanol, compared to v1 produced 15.31%. This study showed a basis for the existence of two sugar-rich climate smart sweet sorghum varieties with an extraordinary amount of sugar used as a source of biofuel and food simultaneously in a single plot of land.
LMCNet: A Lightweight Multi-class Counting Network with Ghost Attention Mechanism and Focal-L2 Loss
Authors: Zhang Li , Wei Xiangyi , Yu Houshun , Jin Lu
Published: October 2023

At present, the research of object counting mostly focuses on single object counting, such as crowd counting and vehicle counting. In real life scenarios, it is common that crowds and vehicles appear at the same time, so multi-class object counting is more valuable. However, multi-class object counting has not been drawing broad attentiion yet. This study first provides a dataset of real scene multi-class counting (RSMCOC) for the research of multi-class object counting, and then proposes a lightweight multi-class counting network (LMCNet). In LMCNet, we design a Ghost attention module, adopting the Ghost attention mechanism that is a hybird mechanisem of channel and spatial attention mechanisms. To obtain high quality multi-channel density maps with low computing efficiency, the Ghost attention module takes into account the phenomenon of ''feature map distortion" and mixes the inherent and Ghost feature maps, where the latter is generated by a Ghost module. Moreover, LMCNet develops a novel loss function, called Focal-L2, which is suitable for multi-class object counting tasks. This loss function can adaptively allocate weights to the loss of each category, avoiding the problem caused by class imbalance. For comparison, we extend existing single object counting algorithms to multi-class counting tasks by changing the output channels of these algorithms. Through extensive experiments on the RSMCOC dataset, we demonstrate that the proposed model achieves a better balance of counting performance and computing efficiency compared to existing models.
TEC-miTarget: enhancing microRNA target prediction based on deep learning of ribonucleic acid sequences
Authors: Yang Tingpeng , Wang Yu , He Yonghong
Published: October 2023

Background
MicroRNAs play a critical role in regulating gene expression by binding to specific target sites within gene transcripts, making the identification of microRNA targets a prominent focus of research. Conventional experimental methods for identifying microRNA targets are both time-consuming and expensive, prompting the development of computational tools for target prediction. However, the existing computational tools exhibit limited performance in meeting the demands of practical applications, highlighting the need to improve the performance of microRNA target prediction models.
Results
In this paper, we utilize the most popular natural language processing and computer vision technologies to propose a novel approach, called TEC-miTarget, for microRNA target prediction based on Transformer Encoder and convolutional neural networks. TEC-miTarget treats RNA sequences as a natural language and encodes them using a Transformer Encoder, a widely used encoder in natural language processing. It then combines the representations of a pair of microRNA and its candidate target site sequences into a contact map, which is a three-dimensional array similar to a multi-channel image. Therefore, the contact map's features are extracted using a four-layer convolutional neural network, enabling the prediction of interactions between microRNA and its candidate target sites. We applied a series of comparative experiments to demonstrate that TEC-miTarget significantly improves microRNA target prediction, compared with existing state-of-the-art models. Our approach is the first approach to perform comparisons with other approaches at both sequence and transcript levels. Furthermore, it is the first approach compared with both deep learning-based and seed-match-based methods. We first compared TEC-miTarget’s performance with approaches at the sequence level, and our approach delivers substantial improvements in performance using the same datasets and evaluation metrics. Moreover, we utilized TEC-miTarget to predict microRNA targets in long mRNA sequences, which involves two steps: selecting candidate target site sequences and applying sequence-level predictions. We finally showed that TEC-miTarget outperforms other approaches at the transcript level, including the popular seed match methods widely used in previous years.
Conclusions
We propose a novel approach for predicting microRNA targets at both sequence and transcript levels, and demonstrate that our approach outperforms other methods based on deep learning or seed match. We also provide our approach as an easy-to-use software, TEC-miTarget, at https://github.com/tingpeng17/TEC-miTarget. Our results provide new perspectives for microRNA target prediction.
Betel quid chewing and alcohol consumption could be associated with detection of Epstein - Barr virus (EBV) DNA in oral squamous cell carcinoma tissues: Evidence from a subset of an unmatched case-control study
Authors: Perera Manosha Lakmali
Published: October 2023

Introduction:
There is a dearth of information on the detection of oncogenic EBV in oral squamous cell carcinoma tissues in the Sri Lankan context. This subset of an unmatched case-control study aims to detect EBV-DNA in oral squamous cell carcinoma tissues of a group of Sri Lankan male patients.
Method
Subset was selected representing the vast majority of OSCC patients in Sri Lanka, from an unmatched case-control study. Incisional biopsies of cases and excisional biopsies of controls were collected and stored at -800 C. DNA was extracted from frozen specimens, and Real-Time PCR was performed to detect target DNA of this ubiquitous virus, in histologically confirmed 27 Oral Squamous Cell Carcinoma (OSCC) cases and clinically diagnosed 26 Fibroepithelial-Polyp (FEP) controls with better quality DNA. Socio-demographic and substance abuse data were collected from 29 cases and 25 controls by a pretested interviewer-administered questionnaire, and the data were entered and analyzed using the SPSS-21 Statistical Package.
Results
Descriptive and inferential statistics were used to determine the significance of qualitative and quantitative data statistically. The overall EBV prevalence was 34/53 (64.2%). In OSCC cases the EBV positivity was higher 21(77.8%) than the FEP controls 13 (50.0%), and this difference was statistically significant (p = 0.035). The cases were higher betel quid chewers (p = 0.003) and heavy alcohol consumers (p = 0.001) than the control group.
Conclusion
Betel quid chewing and alcohol consumption could be associated with the detection of Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma tissues which warrants further investigations.
Academic stress and home environment: A quantitative study among school adolescents
Authors: Santhakumar K , Karim Mani Abdul , Venkatachalam J
Published: October 2023

Academic performance is negatively impacted by an unfriendly home environment and increases academic stress among school students. This study examined the association between academic stress and home environment as well as explored the influence of the home environment in causing academic stress among adolescent school students. One hundred and twenty (120) school students were randomly selected from a government school and three private schools in Tiruvannamalai district, Tamil Nadu, India, and completed the measures of academic stress and home environment by using the Educational Stress Scale for Adolescent (ESSA; Sun et al., 2011) and Home Environment Inventory (HEI; Mishra, 1983). The findings revealed that academic stress did not differ significantly among school students, regardless of gender or type of school (government vs. private). In the home environment, however, there was a significant gender difference in the control sub-dimension and social isolation. Also, there was an association between academic stress and home environment dimensions such as control, punishment, and deprivation of privileges. Punishment was positively influenced by academic stress, whereas nurturance was negatively influenced by academic stress. These findings were discussed about the reduction of negative home environment outcomes in individuals experiencing academic stress.
An optimized method to culture human primary lung tumor cell spheroids
Authors: Mueggler Amanda , Pilotto Eléa , Perriraz-Mayer Nadja , Jiang Sicong , Addeo Alfredo , Bédat Benoit , Karenovics Wolfram , Triponez Frédéric , Serre-Beinier Véronique
Published: October 2023

Background: Lung cancer is the leading cause of cancer mortality worldwide, with a median survival rate at 5 years of less than 20%. While molecular mapping aids in selecting appropriate therapies, it cannot predict personalized treatment response and long-term efficacy. For addressing these challenges, there is a great need for functional tests. Within this context, we developed patient-derived spheroids (PDS) from tumor and adjacent normal tissue to biomimic the respective tissue for assessing the personalized drug treatment response in vitro.
Materials and Methods: Surgically resected lung specimens were used to generate spheroids using a two-step culture procedure. Flow cytometry and immune staining enabled the characterization of different cell populations resulting from the lung samples. PDS phenotype, cell proliferation and apoptosis were evaluated. Differential gene expression between tumor and adjacent normal tissue was analyzed by RT-qPCR. PDS drug sensitivity was assessed using a cell metabolic assay in response to two chemotherapeutic drug combinations.
Results: Cellular and molecular analysis revealed the proportion of epithelial cells, fibroblasts, and immune cells in the patient’s tissue samples. Subsequently, PDS models from tumor and normal lung were successfully established using the expanded epithelial cells. As a proof-of-concept, analysis of drug treatment using PDS of lung adenoid cystic carcinoma exhibited dose dependent effect in response to cisplatin/etoposide and cisplatin/paclitaxel.
Conclusions: We successfully developed spheroid models of both tumor and non-tumor lung cells as a potential platform towards personalized drug treatment and monitoring applications. Our model holds great promise for enhancing the treatment efficacy in the cancer patients.
Prosthodontic Rehabilitation of a Patient Suffering from Ectodermal Dysplasia – A Case Report
Authors: Abhishek Gupta  , Shalabh Kumar  , Gyan Abhishek  , Goyal Sakshi , Jindal Devesh
Published: October 2023

Ectodermal dysplasia is a rare congenital disease that affects several ectodermal structures. Children with ectodermal dysplasia may have various manifestation of the disease that differ in severity and may involve teeth, skin, hair, nails, sweat glands and sebaceous glands. A 16 years Old girl reported in the department of Prosthodontics and crown bridge,with chief complain of of inability to masticate and her unesthetic appearance. She desired replacement of her missing teeth. Family history revealed similar findings in her 18-year old brother. Clinical findings and family history suggested a diagnosis of hypohydrotic ectodermal dysplasia. The present clinical report demonstrated that maxillary flexible RPDs associated with direct composite restorations, Zirconia crowns and mandibular complete denture with CEKA supported Stud attachment are a reversible, relatively inexpensive method of treatment for ectodermal dysplasia patients especially during their growth years. The esthetic, light weight, and good retentive and fracture properties of the flexible denture base materials make a good alternative to the conventional and cast partial dentures.
Management of Fenestration in a Non-vital Maxillary Lateral Incisor Using Connective Tissue Grafting: A Pin-hole Surgical Technique.
Authors: Khanam Farheen , Yadav Upma , Sareen Shubham , Khan Saif
Published: October 2023

Mucosal fenestration is clinical entity in which the overlying gingiva or mucosa is also denuded thus the root is exposed to oral cavity.   If left untreated, they may be a source of infection by giving entry to oral pathogen, leading to further progression of periodontal disease. Depending on their site of presence, they may also be a reason of esthetic concern to some patients. This case report describes a situation where a mucosal fenestration developed in the upper left lateral incisor, which was successfully treated with followed by subepithelial connective tissue grafting.
Clinical Efficacy of Two Denture Adhesives Among Complete Denture Patients: A Cross-over Randomized Clinical Trial
Authors: Sreeramulu Basapogu  , Janaki Ramesh  , Vineela Pyla  , Bharat Chandra Velamakuri
Published: October 2023

Aims and objectives: The clinical efficacy of different forms of denture adhesives have been inconsistent among studies with unclear differences among them. The aim of this study is to evaluate the masticatory efficiency and satisfaction of complete denture wearers without and with the use of two different forms of commercially available denture adhesives.

Material and Methods: 30 edentulous participants with new complete dentures placed one month before the commencement of the study were included in this cross-over randomized clinical trial (CTRI/2021/07/035238) which compared a powder adhesive and a cream adhesive along with no adhesive use. The objective assessment used the Edlund and Lamm index for masticatory efficiency and the subjective assessment followed a specially designed questionnaire. Both assessments were carried out on days 0,7 and 21. One-way ANOVA was used to compare the objective data and the questionnaire responses were obtained as percentages.

Results: The one-way ANOVA test for difference between the groups was statistically insignificant for all layers (P>.05). The questionnaire responses revealed that 53.3% of the participants preferred the use of cream adhesive over powder adhesive.

Conclusions: No significant difference in the masticatory efficiency was noted between the two denture adhesives and without adhesive use. Patient satisfaction was greater with adhesive use showing a predilection towards cream adhesive due to its longer duration of action and improved chewing ability.
Striking the Equilibrium: Examining the Career-Family Balance of Female Dentists in India
Authors: Agrawal Jyoti , Agrawal Rajesh Kumar
Published: October 2023

Abstract

 

Aims and objective

 

India is having more than 300 oral health educational institutions with higher ratio of female students. Therefore the issue of female oral healthcare professionals balancing career and family is becoming more precise. A married female has to create equilibrium between the two different spheres of her life-home and work. Aim of this research was to find out the challenges faced by a female Dentist.

 

Material and method

 

This study is being conducted by undertaking a national cross-sectional survey of working female dentists. A statistically significant number of female dentists of age 25-60 years were subjected to written consent form. After their consent a survey questionnaire was given to them to record how they balance their family and professional life.

Result

 

 

Majority of Indian female dentists work full time in their private practice. No emotional distress on losing practice due to discomfort during pregnancy. Balance between professional work and house hold chores is maintained with the assistance of a house-help. They will keep themselves updated by joining professional associations and fore go joining social clubs for business

 

promotion to strike a balance in personal and professional life. Family is priority in need. They feel tired due to work load of home and profession.

 

Conclusion

 

Most of the time women have to sacrifice their professional life especially during pregnancy & illness of the children/other member.
On the pathogenetic classification of primary angleclosure glaucoma
Authors: Bakunina N. A. , Balashova L. M.
Published: October 2023

Purpose: to clarify the pathogenetic classification of primary angle-closure glaucoma (PACG) based on genetic studies and retrospective analysis.Material and methods. 28 patients (44 eyes) aged 40 to 75 years with various forms of initial, advanced, advanced and terminal stages of PACG, as well as combined glaucoma, were observed.Results. Pathogenetically significant genetic polymorphisms responsible for synechiogenesis in chronic PACG have been found. Clinical and genetic analysis of PACG showed that the classification based on the clinical course, the mechanisms of closure of the iridocorneal angle (ICA), the distribution by stages of primary closure of the ICA, the severity of the pathological process and the level of intraocular pressure, fail to take into account the genetic characteristics of patients with PACG: these are predetermined at birth. In appositional closure of the ICA, preventive laser iridotomy is indicated, while in synechial closure, preventive iridotomy may aggravate synechiogenesis.Conclusion. A pathogenetic classification of PACG has been proposed, which takes account of its hereditary nature. This classification, is advisable to use when choosing a treatment tactics.
State-of-the-art methods of qualitative and quantitative assessment of eye microcirculation
Authors: Kiseleva T. N. , Petrov S. Yu. , Okhotsimskaya T. D. , Markelova O. I.
Published: October 2023

Circulatory disorders in eye vessels play an important role in the development of ophthalmic pathologies, in particular socially significant diseases such as glaucoma, age-related macular degeneration, diabetic retinopathy, and retinal vascular occlusion. Eye hemodynamics features are an important diagnostic criterion for both ocular and systemic diseases. A comprehensive assessment of blood flow in various structures of the eyeball offers additional information on the pathogenesis of the diseases and helps develop new approaches to monitoring the effectiveness of treatment and vascular pathology prognostication. Thanks to the improved technologies, we have today a variety of invasive and non-invasive techniques for examining ocular hemoperfusion, including those intended for retrobulbar blood flow and intraocular blood circulation evaluation. The review article is focused on the state-of-the-art techniques: fluorescein angiography, ultrasound examination involving blood flow assessment by colour Doppler mapping and Dopplerography, optical coherence tomography in the angiographic mode and laser speckle flowgraphy. The role of these techniques in the diagnosis of vascular pathology and their advantages and disadvantages when used in ophthalmological practice is considered.
Efficiency and safety of the fixed latanoprost/ dorzolamide combination in open-angle glaucoma hypotensive treatment
Authors: Neroev V. V. , Petrov S. Yu. , Zhuravleva A. N. , Filippova O. M. , Kalinina O. M. , Yakubova L. V. , Kosakyan S. M. , Vasilenkova L. V.
Published: October 2023

Purpose: to determine the efficacy and safety of fixed latanoprost/dorzolamide combination Dorzoprost in hypotensive treatment of primary open-angle glaucoma (POAG) patients previously treated with latanoprost.Material and methods. An observational study included 30 patients (37 eyes) with moderate and advanced POAG who had uncompensated elevated IOP receiving latanoprost monotherapy. During the screening visit, latanoprost was switched to Dorzoprost instilled once in the evening. The targets were IOP, visual acuity, MD and PSD perimetry indices, retinal nerve fiber layer thickness, minimum width of the neuroretinal rim, macula retinal nerve fiber layer thickness, and adverse events. The observation period lasted 12 weeks. IOP was measured at weeks 4 and 12.Results. After 4 weeks, a statistically significant decrease in IOP was noted, which remained stable at 12 weeks. The average additional IOP decrease of those treated with Dorzoprost was 17%. Statistically insignificant positive changes were registered in visual acuity, static perimetry and optical coherence tomography. By the end of the observation period, 6 cases revealed a decrease in the degree of conjunctival hyperemia, while all dry eye syndrome cases (5 patients) showed a decrease in the severity of the signs of the syndrome.Conclusion. Dorzoprost has a significant additive hypotensive effect and a favorable safety profile.
The role of multifocal electroretinography in the preclinical diagnosis of tumor-associated distant maculopathy in small melanoma of the choroid of extramacular localization
Authors: Saakyan S. V. , Tsapenko I. V. , Myakoshina E. B. , Zueva M. V. , Kotelin V. I.
Published: October 2023

To assess the role of multifocal electroretinography (mf-ERG) in preclinical diagnosis of tumor-associated distant maculopathy in small choroidal melanoma (CM) of extramacular localization.Material and methods. 35 patients (35 affected and 35 fellow eyes) with small CM of extramacular localization and 23 healthy volunteers (46 eyes) aged 59.67 ± 14.2 years were given general ophthalmological examinations and mf-ERG. Density (nV/deg2), culmination time of the P1 component and amplitude (μV) of the N1 component were measured for 5 response rings (R1–R5) at different distances from the fixation point: central hexagon R1: 2.3° (fovea zone); R2: 2.3–6.9° (parafovea); R3: 6.9–14.3° (perifovea); R4: 14.3–20.8° and R5: 20.8–29.9° (middle periphery areas of the retina).Results. Eyes affected by CM showed a decrease in the density of the P1 component in the R1 hexagon by 25.7% of the normal values (p = 0.03). The fellow eyes showed an increase in the density of the P1 component in the R2 ring (p < 0.05). The peak latency of the P1 component in the R1–R5 rings in the affected and fellow eye was found to elongate by 30–45% (p < 0.05). The amplitude of the N1 component in the central hexagon of CM-affected eyes increased by 12.96%, whilst in the R4–R5 rings it decreased by 36–45% as compared with healthy individuals (p < 0.05). The fellow eye showed supernormal values of the N1 amplitude in R1 and its suppression in R4 and R5 rings (p < 0.05).Conclusion. The mf-ERG method is useful for preclinical diagnosis of tumor-associated distant maculopathy in small CM of extramacular localization. Changes in mf-ERG of the fellow eye in patients with small CM have been documented.
A new method to treat persistent corneal erosions after high-risk keratoplasty
Authors: Chentsova E. V. , Borovkova N. V. , Bozhenko D. A. , Ponomarev I. N. , Makarov P. V. , Storozheva M. V. , Makarov M. S.
Published: October 2023

Purpose: to compare the effectiveness of conventional preserved amnion and amnion saturated with platelet-rich (PRP) plasma lysate for the treatment of persistent corneal erosions (PCE) after high-risk keratoplasty.Materials and methods. 40 patients with persistent corneal erosions after high-risk penetrating keratoplasty, followed up for 12 months, were divided into two clinical groups of 20 people each. The main group of patients, aged 34 to 84, received Flexamer amniotic membrane + PRP lysate, while the comparison group, aged 41 to 80, received Flexamer amniotic membrane only. Amniotic membrane coating was used in persistent corneal erosions of penetrating keratoplasty after unsuccessful conservative treatment. The amnion was sewn 2 mm from the limb with a continuous suture and covered with a soft contact lens. As a source of platelets, we used the blood of healthy volunteers, from which platelet-rich plasma with platelet concentration of over 1000 thousand/µl was taken, which was then frozen at -40 °C and defrosted at 0…4 °C to obtain PRP lysate. The criteria for evaluating the effectiveness of both groups were the times of epithelialization, the number of amniotic membrane coatings, and the number of preserved transplants at the end of the follow-up.Results. Lyophilized amniotic membrane saturated with autologous PRP lysate growth factors was shown to be biocompatible. It was found to be safe for the patients, to reduce the epithelialization time, to reduce the number of operations required to cover the PÑE with the amnion, and to increase the likelihood of successful transparent and translucent engraftment of a penetrating keratograft.Conclusion. The use of a lyophilized amniotic membrane enriched with growth factors of autologous PRP lysate is a promising method for the treatment of PCE of the penetrating corneal graft after high-risk keratoplasty.
Influence of Lactose Hydrolyzation on Properties of Yogurt and Sour Milk
Authors: Krysanova Ju. , Bliadze V.
Published: October 2023

The effect of lactose hydrolysis on the properties of fermented milk products has been studied. The following sour-milk products were used to produce experimental samples: lactose-free milk obtained by enzymatic hydrolysis using «Bonlacta™» (15250 SDLU/g, IFF Nutrition & Biosciences Inc., USA); sourdough consisting of Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus salivarius subsp. thermophilus (yogurt) and St. salivarius subsp. thermophilus (sour milk/ prostokvasha). Sour milk and yogurt produced with the same starters but with conventional milk were used as controls. Lactose-free yogurt produced had a stronger clot, fewer viable cells, longer fermentation time and lower titratable acidity compared to the control yogurt. The viscosity of the lactose-free product was slightly different from that of the control. The lactose-free yogurt was also found to have a stronger clot and slightly lower titratable acidity. However, unlike yogurt, the viscosity of the lactose-free sour milk was higher than that of the control, and the duration of fermentation as well as the number of viable cells were the same. Nevertheless, both lactose-free products complied with the Technical Regulation of the Customs Union 033/2013
Presencia de poblaciones de Lycosa hispanica (Walckenaer, 1837) para la provincia de Álava y Condado de Treviño – Burgos, (Arachnida: Aranae, Lycosidae) y primera cita de Steatoda paykulliana(Walckenaer, 1805) para el País Vasco (Arachnida: Aranae, Theridiidae)
Authors: Tejado-Lanseros Conrado , Potes María Elena
Published: October 2023

Se ofrecen observaciones de Lycosa hispanicaen áreas centrales de la provincia de Álava y norte del Condado de Treviño- Burgos, con la detección de pequeños núcleos poblacionales en espacios muy determinados de tipo mediterráneo. Se cita por primera vez Steatoda paykullianapara el País Vasco en la Sierra de Gibijo, contribuyendo a una mayor proyección en el conocimiento de su distribución en el norte peninsular.
Stereoselective Bioreduction of Acetophenone to (R)-1-Phenylethanol by Bacillus
thuringiensis
Authors: Talpur Farah Naz , Ur Rahman Shafiq , Unar Ahsanullah , Ibrahim Adnan , Raza Shah Muhammad , Imran Afridi Hassan , Ali Zafar , Bashir Muhammad Sohail
Published: October 2023

Optically pure alcohols have a pivotal synthetic role, being key intermediates for numerous
pharmaceutical agents. Therefore, the synthesis of optically pure alcohols is now becoming
a foremost research field in both academia and industries. Herein, Bacillus thuringiensis has been
described for the first time for the bioreduction of acetophenone to 1-phenylethanol. Five incubated
bacillus species and a consortium were investigated for the reduction of acetophenone. Among
them, Bacillus thuringiensis (growing cells) exhibited >99% conversion efficiency of acetophenone
(40 mM). The biocatalyst produced (R)-1-phenyl ethanol with excellent stereoselection
(99%) at pH 7.5 after 24 h reaction intervals. To enhance the solubility of substrate and cofactor
regeneration, isopropanol (10% v/v) was found to be effective among different tested cosolvents.
The biocatalyst displayed excellent stereoselectivity and provided R-enantiomer with 99% enantiomeric excess.
Prediction of Surface Settlement in the Cross-passage by FIG-SVM Approach
Authors: Peng Liang , Chen Zhenlei , Zhu Yaohong
Published: October 2023

Introduction:

An optimized support vector machine prediction model (SVM) with
fuzzy information granulation (FIG) is established for surface prediction in this paper. Based on
the measured data, cubic spline interpolation was processed and FIG approach was applied to
granulate the surface settlement parameters into fuzzy particles Low, R and Up, and the particles
are used to represent the range of the measured data variation.

Method:

For each fuzzy particle,
particle swarm optimization (PSO) was used to select the best penalty and kernel function parameters to minimize the K-fold cross-validation (K-CV) error. With the optimized parameters,
the prediction model was trained for the nonlinear prediction of fuzzy particles. Finally, the surface settlement trend in terms of Low, R, Up for the next construction stage can be predicted effectively based on the previous test data. Taking the surface settlement monitoring point D5-5 as
an example, the error of the predicted range of surface settlement at D5-5 is 5.82%, 5.42%, and
8.0%, respectively

Result:

The error of other predicted points is also less than 10%, indicating the
effectiveness of the prediction model. Compared with the numerical simulation results, the accuracy of the prediction model was further verified.

Conclusion:

Combined with the simulation method, the "simulation - prediction" patent scheme
for monitoring the surface settlement of the Cross Passage is proposed in this paper. The research
results indicate that the model proposed in this paper can easily and effectively predict the range
and trend of changes in surface settlement, and is suitable for practical engineering applications.
Ocena stanu odżywienia pacjentów hemodializowanych
Authors: Stadnik Natalia , Antczak-Komoterska Anna
Published: October 2023

Wstęp. Częstość występowania przewlekłej choroby nerek (PChN) wzrasta wraz ze starzeniem się społeczeństwa na świecie. W Polsce jest około 16%. Najczęstszymi przyczynami PChN jest cukrzyca i nadciśnienie tętnicze.  Bardzo duże znaczenie ma wczesne rozpoznanie tej choroby i wdrożenie działań.

Cel pracy. Ocena stanu odżywienia pacjentów hemodializowanych.

Materiał i metody. Metodą badawczą, którą zastosowano w tej pracy jest metoda sondażu diagnostycznego i metoda szacowania. W tej pracy jako techniki badawcze wykorzystano technikę ankietowania i korzystanie ze skali. Narzędzia jakie wykorzystano w tej pracy to Kwestionariusz ankiety własnego autorstwa, subiektywna globalna ocena stanu odżywienia (SGA), skala NRS – Ocena ryzyka związanego ze stanem odżywienia.

Wyniki.Wyniki badań wskazują zależność pomiędzy wieloma czynnikami na stan odżywienia pacjentów hemodializowanych.

Wnioski.

Stan odżywienia nie zależy istotnie od zmiennych socjodemograficznych.

Stan odżywienia zależy istotnie od apetytu, ilości i wielkości zjadanych posiłków. Osoby, u których apetyt jest bardzo słaby i ilość posiłków jest mała wykazują podejrzenie niedożywienia lub niedożywienie średniego stopnia. Osoby, które przyjmują prawidłową ilość posiłków wykazują prawidłowy stan odżywienia

Stan odżywienia zależy istotnie od wypijanych płynów. W grupie pacjentów przyjmujących mniej niż 3 szklanki dziennie wykazują podejrzenie niedożywienia lub niedożywienie w średnim stopniu. W przypadku przyjmowania przez pacjentów większej ilości płynów, stan odżywienia jest prawidłowy.

Stan odżywienia zależy istotnie od występujących dolegliwości i nasilenia choroby. Występowanie dolegliwości takich jak utarta apetytu, nudności, biegunka, wymioty, jadłowstręt może skutkować złym stanem odżywienia. Taki wniosek można wysunąć dzięki przeprowadzonym badaniom własnym.

Stan odżywienia nie zależy istotnie od poziomu wiedzy na temat prawidłowego żywienia. Zależy natomiast istotnie od przestrzegania jego zasad. Osoby nieprzestrzegające zasad prawidłowego odżywiania wykazują nieprawidłowy stan odżywienia lub jego podejrzenie. Chorzy dializowani, którzy podali, że czasami przestrzegają zasad wykazują prawidłowy stan odżywienia.
QUANTITATIVE AND MORPHOMETRIC PLATELET ANALYSIS IN SYSTEMIC SCLERODERMA: EXPLORING ASSOCIATIONS WITH INFLAMMATION AND DISEASE ACTIVITY
Authors: Yatsyshyn R.I. , Drogomeretska O.I.
Published: October 2023

Аннотація

Метою цього дослідження було проведення порівняльного аналізу кількісних та морфометричних показників тромбоцитів у хворих на системну склеродермію (ССД) та у здорових осіб; встановлення можливих зв'язків між цими показниками та індикаторами запалення та активності ССД.

Meтоди

Наше дослідження було проведено ретроспективно. Ми вивчили медичні записи 52 осіб з діагнозом SSc, який було підтверджено за допомогою критеріїв класифікації ACR/EULAR 2013 року, а також національних рекомендацій. Крім того, дослідження охоплювало контрольну групу з 30 здорових учасників. Кожен учасник дослідження пройшов ретельну загальну клінічну оцінку. Ступінь активності захворювання оцінювали згідно з рекомендаціями EUSTAR, а тяжкість уражень шкіри оцінювали за адаптованою шкалою оцінки шкіри Роднана (MRSS). Кожній людині проводився розгорнутий аналіз крові (РАК), а також вимірювалася концентрація С-реактивного білка (CRP). Дослідження тромбоцитарних індексів (ТІ) проводили за даними РАК. Наша основна увага охоплювала загальну кількість тромбоцитів (Plt), середній об’єм тромбоцитів (MPV), ширину розподілу тромбоцитів (PDW), тромбокрит (PCT) і співвідношення тромбоцит-лімфоцит (PLR). Статистичний аналіз зібраних даних проводився за допомогою статистичної програми SPSS 26.0.

Результати

Показники інтенсивності запалення були достовірно вищими серед пацієнтів із ССД у порівнянні із групою контролю. ТІ також продемонстрували статистично достовірну різницю при порівнянні двох груп. Так показники MPV та PDW серед осіб із ССД (9.61±0.05 та 18.43±0.06 відповідно) були нижчими, ніж у представників контрольної групи ( 10.94±0.21 та 18.93±0.11 відповідно). Натомість PCT та PLR навпаки були достовірно вищими саме серед пацієнтів із ССД (0.23±0.04 та 111.4 (94.3-125.7 відповідно). Також було визначено кореляційні взаємозв’язки ТІ та ШОЕ, СRP, індексом активності EUSTAR та MRSS. YНайсильніший кореляційний зв’язок виявився між показниками PDW та СRP (-0.78, p<0.005) та індексом активності EUSTAR (-0.74, p<0.05). Кореляційний зв’язок між ТІ та MRSS був слабкої сили та не продемонстрував статистичної достовірності.

ВисновокРівні тромбоцитарних індексів можуть служити легко вимірюваним фактором, що вказує на запальний статус серед осіб із системною склеродермією.
CHANGES IN THE STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF THE DISTAL COMPARTMENTS OF THE UPPER EXTREMITY AS AN INDICATOR OF THE EFFICIENCY OF THE PHYSICAL THERAPY AND OCCUPATIONAL THERAPY PROGRAM IN THE SOLDIERS WITH GUNSHOT POLYSTRUCTURAL FRACTURE OF
Authors: Zaslavskyi P.S.
Published: October 2023

Резюме. Мета: оцінити ефективність впливу розробленої програми фізичної терапії, ерготерапії (кистьової терапії) на параметри структурно-функціональних характеристик дистальних відділів верхньої кінцівки у поранених з наслідками вогнепального поліструктурного перелому кісток передпліччя у постіммобілізаційному періоді

Методи. Обстежено 49 військовослужбовців з наслідками вогнепального поліструктурного перелому кісток передпліччя у ранньому постіммобілізаційному періоді. Група порівняння (23 осіб) проходила реабілітацію згідно загальних поліклінічних принципів. Основну групу (26 осіб) склали хворі, які проходили реабілітацію із застосуванням засобів та принципів кистьової терапії (терапевтичні вправи та функціональне тренування для китиці та пальців, передпліччя, плеча, всіх суглобів верхньої кінцівки, вправ на столі «MAPS THERAPY»; масаж верхньої кінцівки; кінезіологічне тейпування; Proprioceptive Neuromuscular Facilitation, лікування положенням за допомогою ортезів) тривалістю 2 місяці. Ефективність програми оцінювали за наявністю та ступенем різницею обхватів передпліччя та променево-зап’ясткового суглоба, результатами мануального м’язового тестування, кистьової динамометрії, опитувальником Patient-Rated Wrist Evaluation.

Результати. У поранених з наслідками вогнепального поліструктурного перелому кісток передпліччя у постіммобілізаційному періоді виявлено різницю обхватних розмірів променево-зап’ясткового суглоба та передпліччя, зниження сили м’язів передпліччя та китиці, погіршення їх функціональних здатностей. Після реабілітаційного втручання у всіх обстежених осіб виявлено зменшення різниці обхватних розмірів, збільшились сила китиці та м’язів передпліччя, покращилось функціонування дистальних відділів верхньої кінцівки. За всіма досліджуваними показниками пацієнти обох груп виявили статистично значуще кращий результат у порівнянні із вихідними даними (р<0,05), проте особи основної групи показали кращий результат, ніж пацієнти групи порівняння (р<0,05).

Висновки. Програма кистьової терапії продемонструвала статистично значуще кращий вплив (р<0,05) на всі досліджувані показники у порівнянні із поліклінічною реабілітаційною програмою, що підтверджує необхідність застосування у пацієнтів з ушкодженнями верхньої кінцівки спеціалізованих напрямки відновлення, які враховують анатомо-фізіологічні особливості верхньої кінцівки та її роль у здійсненні активностей повсякденного життя.  

Ключові слова: фізична терапія, ерготерапія, реабілітація, перелом кісток, вогнепальне поранення.
DYNAMICS OF CHANGES IN FUNCTIONAL LIMITATIONS AND ACTIVITY OF THE UPPER EXTREMITIES IN PATIENTS WITH RHEUMATOID ARTHRITIS UNDER THE INFLUENCE OF REHABILITATION TECHNOLOGY
Authors: Nogas A.O.
Published: October 2023

Резюме. Питання відновного лікування із застосуванням реабілітаційних заходів є надзвичайно важливим для пацієнтів з ревматоїдним артритом з метою покращення функціональної активності верхніх кінцівок, досягнення тривалої ремісії та покращення якості життя.

Мета роботи – оцінити ефективність технології реабілітаційних заходів    за оцінкою функціональних обмежень та активності верхніх кінцівок пацієнтів з ревматоїдним артритом з використанням опитувальника DASH.

Матеріал і методи. У дослідженні взяли участь 188 пацієнтів з ревматоїдним артритом. Всі хворі були розподілені методом рандомізації на контрольну (n=92) та основну (n=96) групи. Пацієнти контрольної групи проходили реабілітацію відповідно до протоколу МОЗ України. Хворі основної групи займалися за запропонованою технологією реабілітаційних заходів, що містила наступні елементи: терапевтичні вправи, лікувальний масаж, фізіотерапію, гідротерапію, ортезування, кінезіотейпування верхніх кінцівок, механотерапію та психологічну підтримку пацієнта. Для оцінки функціональних обмежень та активності верхніх кінцівок застосовували опитувальник DASH.

Результати. За оцінкою результатів опитувальника DASH пацієнти обох груп 73,9% зазначили, що найбільші труднощі у них виникали при виконанні побутових дій, зокрема тих, що потребують сили кисті. Засоби фізичної терапії, які були включені до розробленої технології реабілітаційного втручання, сприяли відновленню функціональної активності верхніх кінцівок у виконанні побутових дій пацієнтів основної групи. Результати показників опитувальника DASH в основній групі достовірно перевищують показники контрольної групи, що підтверджує ефективність впроваджених реабілітаційних заходів. 

Висновки. Розроблена технологія реабілітаційного втручання сприяла покращенню показників пацієнтів основної групи, що характеризують домен активності та участі за МКФ, на що вказують результати опитувальника DASH.

Ключові слова: ревматоїдний артрит, опитувальник DASH, функціональні обмеження верхніх кінцівок, технологія реабілітаційних заходів.
CENTROS ESTADUAIS INTEGRADOS DE EDUCAÇÃO RURAL
Authors: Rodrigues Jadejiski Rainei , Foerste Erineu
Published: October 2023

Este artigo dialoga com a produção de conhecimento acumulado sobre os Centros Estaduais Integrados de Educação Rural (CEIERs) do estado do Espírito Santo e com nossas vivências para problematizarmos a historicidade e a práxis pedagógica desses Centros. Trata-se de uma pesquisa bibliográfica, que buscou dissertações e teses que versam sobre os CEIERs como lócus e/ou objeto de pesquisa e que trazem algum tipo de reflexão com interface pedagógica. As buscas foram realizadas no Catálogo de Teses e Dissertações da CAPES, na Biblioteca Digital Brasileira de Teses e Dissertações do IBICT e no Google Acadêmico. Como resultado, reforçou-se que os CEIERs realizam um trabalho pedagógico diferenciado, relevante e de grande impacto para as comunidades camponesas e que embora o número de estudos acumulados sobre essas instituições tenha crescido na última década, em proporção maior, muitos desafios têm se acumulado.