bluuebunny/crossref_metadata_2025 huggingface dataset:
Thiamine‐dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo
Authors: Bunik Victoria , Aleshin Vasily , Nogues Isabel , Kähne Thilo , Parroni Alessia , Contestabile Roberto , Di Salvo Martino Luigi , Graf Anastasia , Tramonti Angela
Published: January 2022

Vitamins B1 (thiamine) and B6 (pyridox (al/ine/amine)) are crucial for central nervous system (CNS) function and neurogenesis due to the coenzyme action of their phosphorylated derivatives in the brain metabolism of glucose and neurotransmitters. Here, the non‐coenzyme action of thiamine on the major mammalian producers of pyridoxal‐5′‐phosphate (PLP), such as pyridoxal kinase (PdxK) and pyridoxine 5′‐phosphate oxidase (PNPO), is characterized. Among the natural thiamine compounds, thiamine triphosphate (ThTP) is the best effector of recombinant human PdxK (hPdxK) in vitro, inhibiting hPdxK in the presence of Mg2+ but activating the Zn2+‐dependent reaction. Inhibition of hPdxK by thiamine antagonists decreases from amprolium to pyrithiamine to oxythiamine, highlighting possible dysregulation of both the B1‐ and B6‐dependent metabolism in the chemical models of thiamine deficiency. Compared with the canonical hPdxK, the D87H and V128I variants show a twofold increase in Kapp of thiamine inhibition, and the V128I and H246Q variants show a fourfold and a twofold decreased Kapp of thiamine diphosphate (ThDP), respectively. Thiamine administration changes diurnal regulation of PdxK activity and phosphorylation at Ser213 and Ser285, expression of the PdxK‐related circadian kinases/phosphatases in the rat brain, and electrocardiography (ECG). In contrast to PdxK, PNPO is not affected by thiamine or its derivatives, either in vitro or in vivo. Dephosphorylation of the PdxK Ser285, potentially affecting mobility of the ATP‐binding loop, inversely correlates with the enzyme activity. Dephosphorylation of the PdxK Ser213, which is far away from the active site, does not correlate with the activity. The correlations analysis suggests the PdxK Ser213 to be a target of kinase MAP2K1 and phosphatase Ppp1ca. Diurnal effects of thiamine administration on the metabolically linked ThDP‐ and PLP‐dependent enzymes may support the brain homeostatic mechanisms and physiological fitness.

image
Association between coffee drinking and endometrial cancer risk: A meta‐analysis
Authors: Gao Yu , Zhai Peiling , Jiang Fang , Zhou Fushun , Wang Xinbo
Published: January 2022

Aim

Coffee drinking is considered as a risk factor of endometrial cancer (EC). Here, we conducted a meta‐analysis of observational study to evaluate the relationship between coffee drinking and the risk of EC.

Methods

The MEDLINE and EMBASE databases were searched until July 2018. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random‐effects model.

Results

A total of 24 studies (12 case–control and 12 cohort studies) on coffee intake with 9833 incident cases of EC and 699 234 subjects were included in the meta‐analysis. The pooled RR of endometrial cancer for the highest versus the lowest categories of coffee intake was 0.71 (95% CI: 0.65–0.77; I2 = 14%, p for heterogeneity = 0.26). By study design, the pooled RRs were 0.68 (95% CI: 0.56–0.83) for case–control studies and 0.70 (95% CI: 0.63–0.77) for cohort studies. For different regions, the pooled RRs were 0.74 (95% CI: 0.62–0.88) in Europe, 0.71 (95% CI: 0.64–0.79) in United States/Canada, and 0.40 (95% CI: 0.28–0.57) in Japan. By additional subgroup analysis, a stronger inverse association was shown in caffeinated coffee drinkers (RR 0.66, 95% CI: 0.52–0.83), individuals with the higher body mass index (BMI) (RR 0.65, 95% CI: 0.54–0.79), never smokers (RR 0.68, 95% CI: 0.56–0.84), ever smokers (RR 0.56, 95% CI: 0.45–0.70), and those who never used hormone replacement therapy (HRT) (RR 0.88, 95% CI: 0.79–0.98). The consumption of filtered or boiled coffee showed no significant association.

Conclusions

Increased coffee intake is associated with a reduced risk of EC.
The effect of pneumoperitoneum and Trendelenburg position on optic nerve sheath diameter in patients undergoing laparoscopic hysterectomy
Authors: Bayramov Tural , Kilicaslan Banu , Akinci Seda B. , Boyraz Gokhan
Published: January 2022

Background and Aim

Laparoscopic hysterectomy (LH) have been frequently used because of low complication rates and short duration of hospital stay. Elevated intracranial pressure (ICP), a disadvantage of laparoscopic surgery, is caused by the Trendelenburg position (TP) and CO2 pneumoperitoneum (PP). This study aimed to evaluate TP and PP associated changes in ICP by ONSD measurements during LH. The intra‐and inter‐observer consistency and reliability of ONSD measurements were also investigated.

Methods

Sixty patients with were enrolled into this prospective study. ONSD for each patient was measured by three anesthesiologists at T0, T1, T2, and T3 time points. ONSD, mean arterial pressure (MAP), end tidal CO2 (EtCO2), and arterial blood CO2 partial pressure values (PaCO2) were measured at T0: baseline, T1: 10 min after introducing 20 mmHg PP, T2: 10 min after placing the patient in TP and 15 mmHg PP and, T3: 10 min after PP deflation.

Results

The ONSD measured at T1 (5.97 ± 0.49 cm) and T2 (5.95 ± 0.57 cm) were higher than T0 (5.63 ± 0.53 cm) and T3 (5.72 ± 0.47 cm) (p < 0.05). There were no correlations between MAP and ONSD, and also between PaCO2, EtCO2, and ONSD measurements at any time points. Inter‐observer intraclass correlation coefficient (ICC) values of ONSD measurements by all examiners had moderate (at T1) to good (at T0, T2, T3) reliability. Intra‐observer agreements were reasonable for each observer.

Conclusion

ONSD measurements increase with CO2PP and TP in patients undergoing LH. Transorbital sonography is a reliable method to monitor intraoperative changes in ONSDs. This study underlines the need for careful training and the importance of standardization in order to obtain reliable results in the examination technique of ONSD measurements.
Dark respiration rates are not determined by differences in mitochondrial capacity, abundance and ultrastructure in C4 leaves
Authors: Fan Yuzhen , Scafaro Andrew P. , Asao Shinichi , Furbank Robert T. , Agostino Antony , Day David A. , von Caemmerer Susanne , Danila Florence R. , Rug Melanie , Webb Daryl , Lee Jiwon , Atkin Owen K.
Published: January 2022

Our understanding of the regulation of respiration in C4 plants, where mitochondria play different roles in the different types of C4 photosynthetic pathway, remains limited. We examined how leaf dark respiration rates (Rdark), in the presence and absence of added malate, vary in monocots representing the three classical biochemical types of C4 photosynthesis (NADP‐ME, NAD‐ME and PCK) using intact leaves and extracted bundle sheath strands. In particular, we explored to what extent rates of Rdark are associated with mitochondrial number, volume and ultrastructure. Based on examination of a single species per C4 type, we found that the respiratory response of NAD‐ME and PCK type bundle sheath strands to added malate was associated with differences in mitochondrial number, volume, and/or ultrastructure, while NADP‐ME type bundle sheath strands did not respond to malate addition. In general, mitochondrial traits reflected the contributions mitochondria make to photosynthesis in the three C4 types. However, despite the obvious differences in mitochondrial traits, no clear correlation was observed between these traits and Rdark. We suggest that Rdark is primarily driven by cellular maintenance demands and not mitochondrial composition per se, in a manner that is somewhat independent of mitochondrial organic acid cycling in the light.
Molecular cues of sugar signaling in plants
Authors: Choudhary Anuj , Kumar Antul , Kaur Nirmaljit , Kaur Harmanjot
Published: January 2022

Sugars, the chemically bound form of energy, are formed by the absorption of photosynthetically active radiation and fixation in plants. During evolution, plants availed the sugar molecules as a resource, balancing molecule, and signaling molecule. The multifaceted role of sugar molecules in response to environmental stimuli makes it the central coordinator required for growth, survival, and continuity. During the course of evolution, the molecular networks have become complex to adapt or acclimate to the changing environment. Sugar molecules are sensed both intra and extracellularly by their specific sensors. The signal is transmitted by a signaling loop that involves various downstream signaling molecules, transcriptional factors and, most pertinent, the sensors TOR and SnRK1. In this review, the focus has been retained on the significance of the sugar sensors during signaling and induced modules to regulate plant growth, development, biotic and abiotic stress. It is interesting to visualize the sugar molecule as a signaling unit and not only a nutrient. Complete information on the downstream components of sugar signaling will open the gates for improving the qualitative and quantitative elements of crop plants.
Evaluation of TNF‐α and IL‐6 in saliva among diabetic retinopathy patients in East Coast Malaysia
Authors: Khairul‐Anwar Ibrahim , Wan‐Nazatul‐Shima Shahidan , Siti‐Lailatul‐Akmar Zainuddin , Siti‐Azrin Ab Hamid , Zunaina Embong
Published: January 2022

Objective

To compare tumour necrosis factor‐alpha (TNF) and interleukin (IL)‐6 levels in saliva between different stages of diabetic retinopathy (DR).

Methods

This comparative cross‐sectional study was conducted between January 2018 and November 2020. This study included diabetes mellitus (DM) patients with no DR, non‐proliferative DR (NPDR), and proliferative DR (PDR). None of the patients with DM were included in the control group. Unstimulated saliva samples were then collected. TNF‐α and IL‐6 levels were measured.

Results

Altogether, 120 patients were included in the study (DM without DR, 33 patients; DM with NPDR, 30 patients; DM with PDR, 32 patients; non‐DM, 25 patients). The mean IL‐6 level in saliva was significantly higher in the DM group (0.033 ± 0.005 pg/ml) than in the non‐DM group (0.027 ± 0.001 pg/ml) (p < 0.001 after adjusting for covariates). There was no significant difference in the mean salivary TNF‐α between patients with DM and those without DM after adjusting for covariates. The mean IL‐6 in saliva was significantly higher in the NPDR (0.036 ± 0.003 pg/ml) and PDR (0.093 ± 0.023 pg/ml) groups than in the no DR group (0.027 ± 0.001 pg/ml) (p < 0.001 and p < 0.001, respectively). Mean TNF‐α in saliva was significantly higher in the NPDR (0.086 ± 0.022 pg/ml) and PDR (0.093 ± 0.023 pg/ml) groups than in the no DR group (0.049 ± 0.011 pg/ml) (p = 0.015 and p = 0.003, respectively).

Conclusion

There is an association between inflammatory biomarkers in saliva (IL‐6 and TNF‐α) and severity of DR among patients with DM, suggesting that these salivary biomarkers are potential biomarkers for screening, monitoring, and predicting the progression of DR.
A standardized multi‐method survey to enhance characterization of riparian invertebrate communities
Authors: Webb Jonathan R. , Gething Kieran J. , Kratz Christoph C. , England Judy , Drewitt Allan L. , Stubbington Rachel
Published: January 2022

Riparian invertebrate communities are species rich, but variability in sampling methods hampers assessment of their distributions and inference of the quality of their habitats. To reduce this variability, a standardized, multi‐method survey protocol was recently developed. Here, riparian beetle community surveys conducted before and after the protocol's introduction were used to evaluate its effectiveness in characterizing communities and in limiting variability among surveys. Use of the standardized protocol reduced variability in sampling effort, and this had a limited effect on estimates of taxonomic richness. Surveys using the protocol captured significantly more species than surveys done before its introduction, evidencing the benefits of standardized multi‐method survey protocols. Our study highlights that standardized multi‐method survey protocols may enable identification and prioritization of sites requiring management to improve habitat quality. As such, we recommend the integration of such protocols into monitoring programmes, to enhance protection of biodiverse invertebrate communities in vulnerable riparian habitats.
The Beginnings of Jewish Primitivism
Authors: Spinner Samuel J.
Published: January 2022

Chapter 1 shows how an incipient Jewish literary modernism based on the aesthetics of romantic nationalism was challenged by the emergence of avant-garde primitivist critique. The folklore-inspired Jewish literature of the turn of the twentieth century was influential culturally and politically, in its contribution to the formation of a modern Jewish literary canon. But it also prompted a backlash by members of the avant-garde who cast the Herderian folklorism of the neo-Romantics as mere “stylization” and called for the aesthetic, but not its subject matter, to be discarded. This critique opened the door to a Jewish primitivism that sought to push beyond neo-Romantic aesthetics while remaining ambivalent about its ethno-nationalist politics.
The Possibility of Jewish Primitivism
Authors: Spinner Samuel J.
Published: January 2022

Chapter 3 presents Franz Kafka as a Jewish primitivist. This runs counter to the prevailing view that sees Kafka apart from broader trends in European Jewish literature. Kafka’s works connect the contradictions of Jewish primitivism to his ambivalence about his Jewish identity. This perspective casts a new light on several of Kafka’s core texts, including “Before the Law” and “A Report to an Academy.” Kafka’s presumed avoidance of introducing Jewishness into his aesthetics is actually a manifestation of the instability and critique of authenticity at the heart of Jewish primitivism.
The Gaze
Authors: Hellner-Eshed Melila
Published: January 2022

This chapter discusses “the gaze” as healing, in mother-child relationships and in the divine faces. We also look at the restorative power of bathing in the light of God’s face.
Arraying Arikh Anpin’s Beard
Authors: Hellner-Eshed Melila
Published: January 2022

This chapter provides an overview of the beard in Zohar and idraic literature as well as the thirteen tiqqunim of the beard.
The Theory of Strategic Alliance Diffusion
Authors: Kuo Raymond C.
Published: January 2022

This chapter offers a social theory of diffusion to explain the dominant alliance strategy. Major wars shatter the international system. Into this breach, a new hegemon creates a core pact targeting its central security challenge. This partnership becomes the standard for credible and legitimate security policy in the postwar environment. Secondary countries copy its strategy to demonstrate the credibility of their own alliances. Peripheral nations emulate to acquire international status and prestige.
It’s not too late
Authors: Topol Eric
Published: January 2022

As the Biden administration took office last January, with the pandemic peaking at more than 130,000 COVID-19 hospitalizations in the United States, there were high hopes for a new plan of “sticking to the science” and expectations that public health policies, communication, and trust would return to levels not seen for many years. That didn’t happen. Why?
A retrospective cohort study of three wound catheter infusion analgesia regimes after midline laparotomy
Authors: Perry Jonathan , Byth Karen , Bullingham Alan
Published: January 2022

Background

Local anesthetic wound infusion catheters are increasingly used postmidline laparotomy to reduce pain and opioid use, however there is little evidence to support any particular infusion regime.

Methods

A retrospective cohort study was undertaken of patients after midline laparotomy who had bilateral local anesthetic wound infusion catheters surgically placed. Patients were recruited into 3 cohorts: ropivacaine 0.2% 5–8 mL/hour continuous wound infusion, 10 mL programmed intermittent bolus 2 hourly, 20 mL programmed intermittent bolus 4 hourly. The primary outcome was the maximum daily Numerical Rating Pain Score with movement (dynamic pain score) recorded during first 96 hours postprocedure. Secondary outcomes included the maximum daily resting pain score and opioid utilization.

Results

In three cohorts of 70 patients (n=210), the maximum daily dynamic pain score in the intermittent bolus 2-hourly and 4-hourly cohorts was lower when compared with the continuous infusion group over the first 4 postoperative days. The mean difference in maximum daily pain score with respect to the continuous infusion regime was 0.8 (95% CI 0.2 to 1.4) for the intermittent bolus 2-hourly group and 0.6 (95% CI 0.0 to 1.2) for the 4-hourly group. Generalized estimating equation modeling indicates the reduction in dynamic pain score is greatest with the intermittent bolus 2-hourly regime over the first 72 hours postprocedure. The 2-hourly intermittent bolus regime was also associated with lower opioid utilization and local anesthetic exposure.

Conclusions

Intermittent wound infusion catheter infusion regimes were associated with lower maximum daily dynamic pain scores, although the magnitude of this change may be of limited clinical significance.
Feature selection by genetic algorithm in nonlinear taper model
Authors: Lacerda Talles Hudson Souza , Miranda Evandro Nunes , Lopes Isáira Leite e , Fonseca Guilherme Rodrigues , França Luciano Cavalcante de Jesus , Gomide Lucas Rezende
Published: January 2022

Tree stem profile results from a complex structure of shapes and dimensions determined by ecological processes within the forest. However, the feature selection in the development of taper models has been underinvestigated to date. We propose a genetic algorithm (GA) to assess factors that affect the stem taper and volume of Eucalyptus urograndis trees at different ages (2, 7, and 14 years) in Brazil. A total of 213 sample trees were measured in diameter and height along the stem, crown width, crown base height, crown length, and crown ratio. These variables and the stand age were supplied to the GA that selects variables, replacing those of Kozak’s 2004 model. The performance of models was evaluated using error statistics and residual plots. The GA model was efficient in predicting diameters and volumes, mainly by increasing the accuracy of the estimates in the extreme portions of the trees. This was attributed to the selection of morphometric variables as predictors of stem taper and volume, making them understandable in ecological terms. We highlight GA as a robust tool, since it incorporated the morphometric variables in Kozak’s model that contribute to the estimates.
Special Issue on The Workshop on MAthematical performance Modeling and Analysis (MAMA 2021)
Authors: Squillante Mark S.
Published: January 2022

The complexity of computer systems, networks and applications, as well as the advancements in computer technology, continue to grow at a rapid pace. Mathematical analysis, modeling and optimization have been playing, and continue to play, an important role in research studies to investigate fundamental issues and tradeoffs at the core of performance problems in the design and implementation of complex computer systems, networks and applications.
ARIMA Model and Few-Shot Learning for Vehicle Speed Time Series Analysis and Prediction
Authors: Wang Yingzi , Yu Ce , Hou Jue , Chu Sisi , Zhang Yongjia , Zhu Yue
Published: January 2022

In the fields of traffic management, traffic health, and vehicle safety, vehicle speed prediction is an important research topic. The greater the difference between vehicle speed and average vehicle speed, or the more discrete the vehicle speed distribution, the higher the accident rate. This paper proposes a vehicle speed prediction method based on adaptive KF (Kalman filtering) in the ARMA (Autoregressive Moving Average) environment to address the problem of high-speed moving vehicle speed prediction. The ARMA theory is used to model the prediction of speed time series. The contribution rate of each coefficient representing the original time series is different after fitting the original time series with the ARMA model, so each coefficient must be given a certain weight. Multisource traffic data fusion and interval speed prediction are carried out on the basis of few-shot data preprocessing and traffic state division, according to different traffic states. The speed prediction accuracy is very high, according to the algorithm verification results.
Invasive Malassezia pachydermatis Infection in an 8-Year-Old Child on Lipid Parenteral Nutrition
Authors: Teoh Zheyi , Mortensen Joel , Schaffzin Joshua K.
Published: January 2022

Invasive disease due to Malassezia pachydermatis infection is uncommon but increasingly recognized in children, especially neonates on parenteral nutrition or immunocompromised children. We describe a case of Malassezia pachydermatis fungemia in a demographically distinct patient and discuss the workup and current strategies for managing this infection in the setting of a central venous catheter.
Frequency and Predictors of Pulmonary Arterial Stump Thrombosis following Pneumonectomy or Lobectomy
Authors: Gurel Durmus Zerrin , Bulbul Yilmaz , Tekinbas Celal , Seyis Kubra Nur , Kosucu Polat
Published: January 2022

Objectives: Pulmonary artery stump thrombosis (PAST) following pneumonectomies/lobectomies is rare; its clinical importance is unknown. The objectives of this study were to analyze the prevalence and risk factors of PAST and the clinical significance in patients with pneumonectomy/lobectomy. Methods: All adult cases who underwent pneumonectomy/lobectomy in our hospital for any reason and who underwent control contrast-enhanced thoracic CT during the follow-up period were included in the study. Demographic and clinical features of the patients, data on surgery, and the features of thrombi were recorded. Results: During the 4-year study period, a total of 454 patients underwent pneumonectomy/lobectomy (93 pneumonectomy and 361 lobectomy). Among the patients, 202 patients (50 pneumonectomy and 152 lobectomy) with at least one follow-up thorax CT were included in the analyses. PAST was detected in 9 (4.5%) of 202 patients and mostly seen in patients with pneumonectomy (lobectomy: 2.6% vs. pneumonectomy: 10%, p = 0.043) and in patients whose pulmonary artery was ligated by using stapler (suture ligation 1% vs. stapler: 7.4%, p = 0.034). Pulmonary artery stump was also longer in patients with PAST (8.48 ± 11.22 mm vs. 23.55 ± 11.22 mm, p < 0.001). Univariate logistic regression analysis showed that pneumonectomy and longer pulmonary artery stump length were found to be significantly associated with PAST (p = 0.041 and p = 0.001, respectively). Conclusions: PAST was detected in 4.5% of our subjects undergoing lobectomy/pneumonectomy. PAST was found to be significantly higher in subjects who underwent pneumonectomy, those with longer pulmonary artery stump, and those with pulmonary artery stump ligated by using stapler.
Profil Klinikopatologi Karsinoma Payudara di Instalasi Patologi Anatomi RSUD Dr. Saiful Anwar Malang
Authors: Ervina Rita , Norahmawati Eviana , Angelina Aina
Published: January 2022

Kanker payudara pada wanita menempati urutan pertama kanker primer tersering, dengan tingkat kematian tinggi. Penelitian ini bertujuan memberikan data gambaran dasar profil klinikopatologi dan imunohistokimia karsinoma payudara invasif karena belum ada data profil klinikopatologi kanker payudara di RSUD Dr. Saiful Anwar Malang. Penelitian ini observasional deskriptif, teknik total sampling, desain penelitian Cross Sectional. Menggunakan data dari rekam medis di Instalasi Patologi Anatomi RSUD Dr. Saiful Anwar Malang periode Januari 2018 - Maret 2020. Variabel yang diukur usia, lokasi payudara, jenis spesimen, histopatologi, derajat keganasan histopatolgis (grading), dan profil immunohstokimia. Hasil menunjukkan kejadian karsinoma payudara invasif terbanyak pada tahun 2019 sebanyak 270 kasus (50%), rentang usia tertinggi antara 46 - 55 tahun sebanyak 142 orang (28%). Teknik pengambilan sampel dengan cara mastektomi sebesar 316 (58%) dibandingkan biopsi sebanyak 226 (42%), lokasi tersering terjadinya karsinoma tidak didapatkan perbedaan bermakna antara payudara kanan atau kiri. Jenis histopatologi terbanyak Invasif Carcinoma of No Special Type (NST) sebesar 475 kasus (88%) dari 542 kasus karsinoma payudara invasif, derajat keganasan histopatologi terbanyak adalah grade III sejumlah 240 kasus (47%). Berdasarkan profil imunohistokimia, Luminal A merupakan kategori tebanyak sebesar 44 kasus (31%), dibandingkan Luminal B, Ekspresi HER2 ataupun kanker payudara tripel negatif. Kesimpulannya adalah usia terbanyak penderita karsinoma invasif payudara terjadi pada usia 46-55 tahun, tidak terdapat perbedaan distribusi karsinoma payudara pada payudara kanan atau kiri, jenis spesimen terbanyak diambil dari Teknik mastektomi, jenis histopatologi terbanyak yaitu invasive carcinoma of NST, derajat keganasan histopatologi terbanyak pada grade III, luminal A terbanyak pada pemeriksaan imunohistokimia karsinoma payudara invasif.
utilização dos dispositivos de comunicação da web social pela biblioteca e pelo memorial universitários
Authors: Santos Raquel do Rosário , Dos Santos Jade de Jesus , Freitas Lívia Santos , Jesus Ingrid Paixão de , Amaral Louise Anunciação Fonseca de Oliveira
Published: January 2022

A interação com os usuários pode ser favorecida por meio dos dispositivos de comunicação da web social que vêm se tornando aliados dos bibliotecários e arquivistas na amplificação e promoção das atividades de mediação da informação. Nesse contexto, o objetivo deste estudo é analisar as interferências dos dispositivos de comunicação do Memorial Arlindo Coelho Fragoso e da Biblioteca Bernadete Sinay Neves na comunidade da Escola da Politécnica da UFBA, analisando seus impactos e sua abrangência. Nesta pesquisa, de natureza descritiva, foi empregado o método de estudo de caso, sendo os objetos de investigação a Biblioteca Bernadete Sinay Neves e o Memorial Arlindo Coelho Fragoso da Escola Politécnica da Universidade Federal da Bahia. Como instrumentos de coleta de dados adotou-se questionários direcionados aos estudantes e gestores e colaboradores da Biblioteca e do Memorial. Os resultados indicaram que foi possível constatar a necessidade de adotar novos métodos de interação com os usuários, utilizando linguagens diferentes, promovendo publicações que podem agregar novos conhecimentos à formação desses usuários. Conclui-se que é necessário avaliar e redimensionar os métodos e as técnicas de promoção e realização das atividades de mediação da informação, também é essencial ressignificar esses ambientes informacionais a fim de torna-los mais dialógicos e interativos, propiciando a atuação dos seus profissionais e que esses consigam manter seus usuários atualizados e interessados nos produtos e serviços disponibilizados.
Tensões epistemológicas na Bibliografia e na Documentação: os diferentes olhares de Otlet e Ranganathan
Authors: Amorim Igor Soares , Sales Rodrigo
Published: January 2022

A compreensão epistemológica a respeito da Bibliografia e da Documentação apresenta perspectivas distintas quanto à natureza das mesmas. Vistas concomitantemente como atividades e como disciplinas, Bibliografia e Documentação foram abordadas de formas diferentes por importantes pensadores do campo informacional, especialmente por Otlet e Ranganathan. Neste contexto, apresentamos um estudo que teve por objetivo investigar a compreensão que Otlet e Ranganathan tiveram a respeito da Bibliografia e da Documentação e como ambos as relacionaram com a Biblioteconomia. Do ponto de vista metodológico, foi realizada uma análise comparativa entre as obras Traité de Documentation (1934), de Otlet, e os livros Social Bibliography or Phisical Bibliography for Librarians (1952) e Documentation: Genesis and Development (1973), de Ranganathan. Os resultados apontaram que, para Otlet, Bibliografia e Documentação eram diferentes estágios de um movimento científico evolutivo que avançara de uma dimensão processual para uma dimensão metodológico-científica, desligando-se da Biblioteconomia e se inserindo na chamada Bibliologia. Para Ranganathan, a Documentação era um conjunto de atividades análogas à catalogação e ao serviço de referência (atividades biblioteconômicas) e a Bibliografia, dotada de maior cientificidade que a Documentação, estava voltada à produção bibliográfica e seu papel na comunicação social, alicerçada também pela Biblioteconomia. Concluímos que o discurso emancipatório de Otlet abriu espaço para a instauração de uma ciência do documento (Documentação), ao passo que o discurso de Ranganathan conferiu autoridade científica à Biblioteconomia para lidar tanto com a Documentação quanto com a Bibliografia.
Transcendência da palavra poética a partir do espaço paisagístico
Authors: Santos Natália Ferreira , Pinheiro Neto José Elias
Published: January 2022

A paisagem se caracteriza como matéria primordial para a união entre elementos sensíveis e inteligíveis, possibilitando a transcendência da palavra poética. Essa pesquisa tem por objetivo analisar como a paisagem enquanto um espaço capaz de possibilitar um dos recursos mais importantes da poesia que o é de transcender a palavra poética. A metodologia adotada nessa pesquisa foi a de revisão bibliográfica, com dados coletados em obras de autores como Gaston Bachelard (1978), Michel Collot (2013), Michael Hamburger (2007), dentre outros autores. Os resultados mostram que os espaços poéticos permitem aos indivíduos uma relação de intercambialidade entre a realidade e a imaginação, objetivo e subjetivo, esses elementos materiais e imaginários são indissociáveis e se interagem de maneira incessante, dando, então, vida à palavra poética.
New species, revalidation, synonymies, and new records in Bebelis Thomson (Coleoptera, Cerambycidae, Lamiinae, Apomecynini)
Authors: SANTOS-SILVA ANTONIO
Published: January 2022

Six new species of Bebelis Thomson, 1864 are described: B. wappesi, B. tinga, and B. skillmani, from Bolivia (Santa Cruz); B. nearnsi, from Bolivia (La Paz); B. parana, from Argentina (Corrientes); and B. imitatrix, from Argentina (Mendoza). Bebelis concisa Galileo & Martins, 2006 and B. angusta (Fisher, 1947) are synonymized with B. modesta (Belon, 1903); B. inaequalis (Fisher, 1947) is synonymized with B. obliquata (Breuning, 1940); B. schwarzi (Fisher, 1947) is synonymized with B. picta Pascoe, 1875; and B. acuta geometrica (Bates, 1880) and B. laetabilis (Belon, 1903) are synonymized with B. acuta Pascoe, 1875. New states records for B. angusta and B. cuprina (Belon, 1903) are provided. Bebelis zeteki (Fisher, 1947) is revalidated and Bebelis aurulenta (Belon, 1903) is illustrated for the first time. A provisional key to species of Bebelis is provided.
One Strike, You’re Out: Lightning during Professional Baseball Games
Authors: Vagasky Chris
Published: January 2022

Millions of people attend Major League Baseball games every year, during a season that is played primarily outdoors at the peak of the U.S. lightning season. In recent years, social media photographs and baseball game television broadcasts have revealed lightning within proximity of several baseball games without the game being delayed. Lightning data from the U.S. National Lightning Detection Network within 12.8 km of 9717 Major League Baseball games between 2016 and 2019 were examined to find the extent to which lightning is a threat to games, players, staff, and fans: 717 games were found to have lightning within 12.8 km, with more than 175 000 in-cloud and cloud-to-ground lightning discharges detected during those games. The distribution of games with lightning was not uniform and is related to the annual average lightning density of each ballpark. Despite the significant risk of a lightning-related incident at Major League Baseball games, existing work from other organizations like the National Collegiate Athletics Association and the National Athletics Trainers Association can be leveraged to improve lightning safety at professional baseball games.

Significance Statement

Nearly one of every 14 Major League Baseball games has lightning within what lightning safety experts would consider an unsafe distance. The potential for a lightning casualty incident is high because most games are played outdoors and millions of people are at baseball games every year. Although frameworks that can improve lightning safety at the thousands of professional baseball games that are played every year exist, it is unclear how frequently they are implemented.
Detect the early-warning signals of diseases based on signaling pathway perturbations on a single sample
Authors: Huo Yanhao , Zhao Geng , Ruan Luoshan , Xu Peng , Fang Gang , Zhang Fengyue , Bao Zhenshen , Li Xin
Published: January 2022

Background

During the pathogenesisof complex diseases, a sudden health deterioration will occur as results of the cumulative effect of various internal or external factors. The prediction of an early warning signal (pre-disease state) before such deterioration is very important in clinical practice, especially for a single sample. The single-sample landscape entropy (SLE) was proposed to tackle this issue. However, the PPI used in SLE was lack of definite biological meanings. Besides, the calculation of multiple correlations based on limited reference samples in SLE is time-consuming and suspect.

Results

Abnormal signals generally exert their effect through the static definite biological functions in signaling pathways across the development of diseases. Thus, it is a natural way to study the propagation of the early-warning signals based on the signaling pathways in the KEGG database. In this paper, we propose a signaling perturbation method named SSP, to study the early-warning signal in signaling pathways for single dynamic time-series data. Results in three real datasets including the influenza virus infection, lung adenocarcinoma, and acute lung injury show that the proposed SSP outperformed the SLE. Moreover, the early-warning signal can be detected by one important signaling pathway PI3K-Akt.

Conclusions

These results all indicate that the static model in pathways could simplify the detection of the early-warning signals.
Machine Learning Analysis of Literature Data on the Water Gas Shift Reaction toward Extrapolative Prediction of Novel Catalysts
Authors: Mine Shinya , Jing Yuan , Mukaiyama Takumi , Takao Motoshi , Maeno Zen , Shimizu Ken-ichi , Takigawa Ichigaku , Toyao Takashi
Published: January 2022

Literature data based on the water gas shift (WGS) reaction have been analyzed using statistical methods based on machine learning (ML). Our ML approach, which considers elemental features as input representations rather than the catalyst compositions, was successfully applied, and new promising catalyst candidates for future research were proposed.
Children after traumatic experiences
Authors: Lenart Angelika
Published: January 2022

Children who have experienced traumatic events in their lives and grew up in an environment that neglected their needs and in which abuse occurred will feel the long-term and varied impact of these events on their lives. That is why, working with children who have experienced trauma is so important but also difficult. Caregivers and educators should first learn about their history and understand the impact of traumatic events they have experienced before focusing on their behaviour. They ought to build appropriate relationships that will allow to gain confidence and a sense of security. The article presents the phenomenon of trauma and its types, the impact of traumatic experiences on child development and the consequences that follow. It was shown what work with a child should look like after traumatic experiences.
UCZEŃ W CYFROWEJ PRZESTRZENI INFORMACJI – O (NIE)OBECNEJ EDUKACJI MEDIALNEJ
Authors: Borawska-Kalbarczyk Katarzyna
Published: January 2022

Celem artykułu jest przedstawienie wybranych problemów procesu użytkowania informacji cyfrowych przez uczniów w kontekście zjawiska nadmiaru informacji. Artykuł przedstawia zjawisko przeciążenia informacyjnego i jego konsekwencje. Postawiona jest teza, że źródłem trudności wykorzystywania informacji są niewystarczające kompetencje informacyjne młodzieży pokolenia cyfrowego. Przedstawione w artykule kompetencje informacyjne, jak również złożoność współczesnego cyfrowego środowiska powodują konieczność wzmocnienia procesu kształcenia kompetencji medialnych uczniów. W zakończeniu podjęta jest dyskusja dotycząca problemów i postulatów kształcenia z zakresu edukacji medialnej w polskim systemie edukacyjnym.
Polyfactorial approach in rehabilitation of football players' muscles after sports injuries
Authors: Vladymyrov Oleksandr , Chukhraiev Nikolay , Shmorgun Аndriy , Zukow Walery , Мaliuta Vladimir , Chukhraieva Olena
Published: January 2022

The article discusses a multifactorial approach to the restoration of muscle volume and rehabilitation of football players after sports injuries, which includes the implementation of electric myostimulation in a magnetic field in combination with the effect of electromagnetic radiation of the visible or infrared spectrum on muscles and the area of injury. Comparative studies were carried out in two groups of footballers in rehabilitation after ankle injury rehabilitation. The medical rehabilitation of the players of the 1st group was carried out according to the protocol approved in the center: the MIT-FM apparatus, the protocol for the implementation of rehabilitation provides for the implementation of drug treatment and physiotherapeutic procedures based on the combined use of therapy with electromagnetic waves of the red, blue and infrared spectral range with a power of 50 mW in a pulsed magnetic field of intensity 30 mT and a pulse repetition rate of 9.4 Hz. 
In group 2, the rehabilitation of footballers after injuries of the lower extremities was carried out according to the protocol developed by the authors: sequential connection of the rehabilitation protocol of the first group and combined magneto-photo electric myostimulation of muscles with myotonic impulses, with a pulse repetition rate of 9.4 Hz. The repetition period of the packs of impulses is 8 seconds with the duty cycle of repetition of the packs of impulses 2. The current strength was set individually for each patient - until the appearance of visible muscle contractions.
Muscle photostimulation was performed with electromagnetic radiation of red (wavelength 0.63 μm, power 30 mW), blue (wavelength 0.45 μm, power 30 mW) and infrared (wavelength 0.75 μm, power 50 mW) spectral ranges in constant magnetic field (intensity 30 mT).
The first electrode is placed on the muscle's innervation zone. The second electrode provides a combined effect of electrical impulses and optical flux in a constant magnetic field on the abdomen of the muscle according to the labile technique.
The time of one procedure was 40 minutes. The number of procedures for a course of treatment is 15.
As a result, the analysis of the data obtained (assessment of the quality of life according to the extended table SF-36) revealed a positive dynamics of clinical manifestations in both groups. The main result of the research is the development of a protocol for the rehabilitation of football players after injuries of the lower extremities based on the use of drug treatment, physiotherapy procedures based on the combined use of therapy with electromagnetic waves of the blue and infrared spectrum in a constant magnetic field in combination with muscle electrostimulation, which has a higher level rehabilitation potential versus applicable footballerІ rehabilitation protocols.
Zwycięstwo bez walki i wojownicy udający kupców. Podstęp Olafa Świętego w Saudungssundzie
Authors: Rutkowski Rafał
Published: January 2022

Zwycięstwo bez walki i wojownicy udający kupców. Podstęp Olafa Świętego w Saudungssundzie
Stosunki Piastów z Rurykowiczami w kompilacji historiograficznej. Współczesna „kolekcja historyczna”
Authors: Jusupović Adrian
Published: January 2022

Niniejszy tekst jest rozważaniem nad sytuacją polskiej humanistyki oraz nad współczesnym warsztatem historyka w zakresie cyrylicznego źródłoznawstwa na przykładzie pracy Krzysztofa Benyskiewicza. Koncentruje się na coraz częstszym problemie funkcjonowania w środowisku naukowym warsztatu opartego na zestawianiu (kompilowaniu) i omawianiu tez różnych autorów z pominięciem solidnej pracy źródłoznawczej.
Toponomastyka w warsztacie badawczym geografii historycznej
Authors: Kowalczyk-Heyman Elżbieta
Published: January 2022

Artykuł, pierwotnie planowany jako rozdział w podręczniku z geografii historycznej, przeznaczony jest głównie dla historyków i archeologów zajmujących się osadnictwem. Autorka przypomina dzieje badań toponomastycznych w Polsce oraz istniejące klasyfikacje nazw miejscowych, wodnych i terenowych. Zwraca uwagę na pułapki nazewnicze, które czyhają na badaczy, przywołując jednocześnie przykłady poprawnych, ale i z gruntu błędnych interpretacji nazw, np. w badaniach nad obronnością ziem polskich, zasięgiem osadnictwa plemiennego czy odtwarzaniem sieci drogowej.
Las lenguas minoritarias en la Sociedad de la Información. Cartografía, revitalización y aprendizaje del aragonés en entornos virtuales.
Authors: Ibáñez-Alcázar Alejandro , García-Marín David
Published: January 2022

El presente trabajo analiza la situación actual de la lengua aragonesa en la Red; una lengua minoritaria y minorizada que, según la UNESCO, se encuentra en peligro de extinción. Sin embargo, gracias a Internet y a la rápida expansión de la Web 2.0, las lenguas minoritarias como el aragonés cuentan con nuevas oportunidades para su revitalización. El objetivo es comprender cómo las nuevas tecnologías y el conjunto de posibilidades que ofrece la Web influyen positivamente en su visibilidad y contribuyen a evitar su desaparición. Para ello, esta investigación -de tipo eminentemente cualitativo- se desarrolla desde dos enfoques: en primer lugar, desde una perspectiva comunicativa, para hacer una aproximación a la presencia, uso y difusión del aragonés en plataformas virtuales; y, en segundo lugar, desde una mirada educativa, para analizar las posibilidades de aprendizaje de esta lengua en estos entornos digitales. Nuestros resultados ponen de manifiesto que la lengua aragonesa está cada vez más presente en la Red y que en los últimos años ha visto incrementada su presencia en plataformas y herramientas virtuales, que pueden facilitar su visibilidad y dignificación. Por contra, su presencia en medios de comunicación online es muy escasa. En la misma línea, se observan reducidas oportunidades para aprender la lengua a través de la Red, tarea manifiestamente laboriosa y complicada por el reducido número de webs donde hallar recursos educativos digitales.
Chapter 2
Authors: Proust Marcel
Published: January 2022

This chapter seeks to revive the Narrator's memory of his grandmother. It shows how Albertine begins to inspire the Narrator to seek happiness once again. The chapter also discusses the Narrator's encounter with Cottard in the little casino filled with girls, and with Mme de Cambremer, who arrived with her daughter-in-law, Mme de Cambremer-Legrandin. It then shifts to recount the quarrel between the Narrator and Albertine involving Saint-Loup. The chapter mentions the Narrator's jealous suspicions to two “coursières,” — Marie Gineste and Céleste Albaret. It investigates why Mme Verdurin has had quite enough of the Dreyfus Affair: Dreyfusism was triumphant politically but not socially.
Chapter 4
Authors: Proust Marcel
Published: January 2022

This chapter tracks the decision of the Narrator to make a definite break with Albertine. It recounts his decision to postpone the conversation to the next day near Parville. The chapter also highlights Albertine's revelation about her close connection to Mlle Vinteuil and her friend. Focusing on the Narrator's agony at sunrise, the chapter recalls the image of the profanation scene the Narrator's witnessed long ago at Montjouvain. The chapter then shifts to highlight the Narrator's request, grief, and a story about a woman he was to have married. Finally, the chapter describes the Narrator's sudden reversal in favor of Albertine. It then chronicles the Narrator's new journey with Albertine for Paris.
Introduction
Authors: Galvin Shaila Seshia
Published: January 2022

The introduction examines how organic agriculture became a crucible for reimagining and remaking the agrarian in the state of Uttarakhand, a region where, for much of the nineteenth and twentieth centuries, agriculture was deemed backward and undeveloped. Organic, it argues, should be understood and studied as a quality that must be assembled, rather than as a distinctive physical, sensory, or material property of land and its produce. It proceeds to set out a framework to provincialize organic, proposing to study organic quality as emergent in historically situated social, cultural, economic, and political practices and relations. In Uttarakhand this entails, first, paying attention to the intersection of organic agriculture with political and economic reforms in India after liberalization; second, it necessitates inquiry into how rural cultivators exercise agency and experience subjectivity through organic farming; finally, it probes how organic agriculture reworks notions of modernity and tradition, nature and agriculture, that powerfully inform understandings of human-environment relations in the Indian Himalaya and beyond. As it relates the making of organic quality to processes of state-making and post-reform development, the introduction affords new insights into the production of agricultural commodities and agrarian relations.
The Limits of Transparency and the Farming of Trust
Authors: Galvin Shaila Seshia
Published: January 2022

Focusing on the farming of certified organic basmati rice in Uttarakhand’s Doon Valley, this chapter examines the relationship between transparency and trust in certification processes. Certification, it is often claimed, affords transparent knowledge about its objects. Because of this, it is thought to be necessary for generating and maintaining widespread public trust. This chapter explores the limits of transparent knowledge, arguing that as organic agriculture becomes established under state government auspices in the Doon Valley, trust is neither solely emergent in personalized relations nor simply an outcome of certification processes. Instead, this chapter shows how practices of organic certification, under conditions of limited transparency, shape and fundamentally reconfigure trust. Through fine ethnography that focuses on sentiments of trust, belief, or faith, expressed by certification inspectors during the course of their work, the chapter traces how such sentiments become integral to the making—and the meaning—of certified organic farming.
Exhibiting Organic Uttarakhand
Authors: Galvin Shaila Seshia
Published: January 2022

This chapter explores how brand-building and state-making intertwine in neoliberal development practice. It examines how the brand “Organic Uttarakhand” established by the Uttarakhand Organic Commodity Board attached itself not just to pulses, grains, and spices produced by organic farmers, but how it became a signifier for the region itself. To make this argument, the chapter considers three distinct trade fairs and exhibition spaces in which the Board participated in 2007 and 2008. These exhibitions proved to be crucial sites in which the promotion of organic agriculture was linked with efforts to build the state’s brand equity as “Organic Uttarakhand.” The circulation of discursive and material artifacts—signs, posters, and brochures as well as agricultural products from the mountains—constituted organic quality through an exhibitionary complex, and helped produce Uttarakhand as an organic state. At the same time, abiding social imaginaries of Uttarakhand as a place of nature and an abode of the gods were also conjured in these domains in order to endow organic products with a singular authenticity as they circulated through new market channels.