bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and Safety of mFOLFOX6 as Perioperative Chemotherapy for Resectable Liver Metastases from Colorectal Cancer: A Case-Control Study
Authors: WADA TAKAHIRO , KATSUMATA KENJI , KASAHARA KENTA , MAZAKI JUNICHI , SHIGOKA MASATOSHI , KAWAKITA HIDEAKI , ENOMOTO MASANOBU , ISHIZAKI TETSUO , NAGAKAWA YUICHI , TSUCHIDA AKIHIKO
Published: May 2022

Background/Aim: Despite the emergence of cellular, animal, and clinical-based evidence demonstrating a link between hypoxia-inducible factor-1α (HIF-1α) and malignancy, the comprehensive assessment of HIF-1α in pan-cancer patients remains unclear, particularly regarding HIF-1α expression and its association with immune infiltration and immune checkpoint. The present study aimed to investigate the role of HIF-1α expression in various types of malignancies through bioinformatics analysis. Materials and Methods: We investigated the expression and prognostic value of HIF-1α in pan-cancer based on the TCGA (The Cancer Genome Atlas) dataset. The abundance of immune infiltration was estimated by xCell immune deconvolution methods. We investigated the relationship of HIF-1α expression with immune infiltration and immune checkpoint gene expression, with a focus on gastric adenocarcinoma (STAD) and lung squamous cell carcinoma (LUSC). Results: HIF-1α expression had different effects on the prognosis of various cancers. In contrast to the protective effect of HIF-1α expression in LUSC, high levels of HIF-1α expression played a detrimental role in the survival of STAD patients. There was a significant positive correlation between HIF-1α expression and immune infiltration in STAD patients, including regulatory T-cells (Tregs), T-cell CD4+ Th2, neutrophils, M1 and M2 macrophages. In addition, immune checkpoint molecules showed different HIF-1α-related profiles in various carcinomas. Conclusion: A relatively comprehensive view of the oncogenic role of HIF-1α in various tumors based on a pan-cancer analysis is provided in this study. HIF-1α may be considered a poor prognostic biomarker for STAD and, moreover, it may be involved in regulating tumor immune infiltration.
Pre-operative Serum Albumin as a Potential Predictor of Benign Lesions in Renal Masses
Authors: SEKITO SHO , OGURA YUJI , SOGA NORIHITO , KOJIMA TAKAHIRO
Published: May 2022

Background/Aim: We investigated pre-operative factors for predicting whether renal masses are benign in order to facilitate the selection of optimal candidates for pre-operative biopsy. Patients and Methods: We evaluated 278 patients with renal masses suspected to be clinically T1 or T2 renal cell carcinoma. All patients had undergone a partial or radical nephrectomy. Pre-operative parameters, including patient characteristics, tumor size, and blood tests, were utilized to predict which lesions were benign. Results: Twenty-five lesions (9.0%) were benign. Multivariate analysis showed that female sex [odds ratio (OR)=2.92, p=0.016], serum albumin ≥4.3 g/dl (OR=3.50, p=0.013), and tumor size 23 mm (OR=3.96, p=0.002) were significant independent factors for benign renal masses. The incidence of benign lesions in cases with all three factors (female sex, higher serum albumin, and smaller tumor size) was 4 of 16 (25.0%), which was significantly higher (p=0.037) than that in all cases (25/278; 9.0%). Conclusion: Relatively high pre-operative serum albumin levels may be a predictor of benign lesions when associated with female sex and smaller tumor size.
Total Risk Points Predict Short- and Long-term Outcomes Following Colorectal Cancer Resection in Older Patients
Authors: HASHIMOTO SHINTARO , TO KAZUO , WADA HIDEO , SAKAKIBARA YUKA , OZEKI KEISUKE , KOMAKI MICHIHIKO , KONDO MASAMICHI
Published: May 2022

Background/Aim: Estimation of physiological ability and surgical stress (E-PASS) is reported to be useful as a predictor of postoperative complications and poor long-term survival after colorectal cancer. The total risk points (TRP) system is a simplified scoring system of E-PASS, and this study evaluated the utility of TRP in colorectal cancer resection in older patients. Patients and Methods: The clinicopathological data of 237 patients who underwent curative resection for colorectal cancer from 2015 to 2020 were analyzed retrospectively. The data were compared between a high TRP group (≥1,000, n=38) and a low TRP group (<1,000, n=199). We also conducted an analysis to determine risk factors of postoperative complications and poor long-term survival. Results: TRP showed statistically significant correlations with the comprehensive risk score (CRS) of E-PASS (R=0.999, p<0.001). The high TRP group experienced postoperative complications (Clavien-Dindo grade ≥2) more frequently (42.1% vs. 11.1%, p<0.001). Multivariate analysis showed that high TRP [odds ratio (OR)=5.214; 95% confidence interval (95%CI)=2.338-11.629; p<0.001] and age ≥80 (OR=2.760; 95%CI=1.308-5.826; p=0.008) were independent predictors of postoperative complications. Overall survival (OS) was poor in the high TRP group (5-year OS, 61.2% vs. 82.6%, p<0.001) compared with the low TRP group, and in the low prognostic nutritional index (<45) group (5-year OS, 70.9% vs. 86.3%, p=0.013) compared with the high prognostic nutritional index (≥45) group. Multivariate analysis showed that high TRP [hazard ratio (HR)=3.202; 95%CI=1.324-7,745; p=0.010] was an independent prognostic factor for poor OS. Conclusion: Patients aged ≥80 years should be closely monitored regarding postoperative complications. Reducing TRP to less than 1,000 is important to reduce postoperative complications and improve OS.
Effects of Pharmacogenomic Testing in Clinical Pain Management: Retrospective Study
Authors: Tagwerker Christian , Carias-Marines Mary Jane , Smith David J
Published: May 2022

Background

The availability of pharmacogenomic (PGx) methods to determine the right drug and dosage for individualized patient treatment has increased over the past decade. Adoption of the resulting PGx reports in a clinical setting and monitoring of clinical outcomes is a challenging and long-term commitment.

Objective

This study summarizes an extended PGx deep sequencing panel intended for medication dosing and prescription guidance newly adopted in a pain management clinic. The primary outcome of this retrospective study reports the number of cases and types of drugs covered, for which PGx data appears to have assisted in optimal drug prescription and dosing.

Methods

A PGx panel is described, encompassing 23 genes and 141 single-nucleotide polymorphisms or indels, combined with PGx dosing guidance and drug-gene interaction (DGI) and drug-drug interaction (DDI) reporting to prevent adverse drug reactions (ADRs). During a 2-year period, patients (N=171) were monitored in a pain management clinic. Urine toxicology, PGx reports, and progress notes were studied retrospectively for changes in prescription regimens before and after the PGx report was made available to the provider. An additional algorithm provided DGIs and DDIs to prevent ADRs.

Results

Among patient PGx reports with medication lists provided (n=146), 57.5% (n=84) showed one or more moderate and 5.5% (n=8) at least one serious PGx interaction. A total of 96 (65.8%) patients showed at least one moderate and 15.1% (n=22) one or more serious DGIs or DDIs. A significant number of active changes in prescriptions based on the 102 PGx/DGI/DDI report results provided was observed for 85 (83.3%) patients for which a specific drug was either discontinued or switched within the defined drug classes of the report, or a new drug was added.

Conclusions

Preventative action was observed for all serious interactions, and only moderate interactions were tolerated for the lack of other alternatives. This study demonstrates the application of an extended PGx panel combined with a customized informational report to prevent ADRs and improve patient care.
Effects of a Novel Blood Glucose Forecasting Feature on Glycemic Management and Logging in Adults With Type 2 Diabetes Using One Drop: Retrospective Cohort Study
Authors: Imrisek Steven D , Lee Matthew , Goldner Dan , Nagra Harpreet , Lavaysse Lindsey M , Hoy-Rosas Jamillah , Dachis Jeff , Sears Lindsay E
Published: May 2022

Background

Personalized feedback is an effective behavior change technique frequently incorporated into mobile health (mHealth) apps. Innovations in data science create opportunities for leveraging the wealth of user data accumulated by mHealth apps to generate personalized health forecasts. One Drop’s digital program is one of the first to implement blood glucose forecasts for people with type 2 diabetes. The impact of these forecasts on behavior and glycemic management has not been evaluated to date.

Objective

This study sought to evaluate the impact of exposure to blood glucose forecasts on blood glucose logging behavior, average blood glucose, and percentage of glucose points in range.

Methods

This retrospective cohort study examined people with type 2 diabetes who first began using One Drop to record their blood glucose between 2019 and 2021. Cohorts included those who received blood glucose forecasts and those who did not receive forecasts. The cohorts were compared to evaluate the effect of exposure to blood glucose forecasts on logging activity, average glucose, and percentage of glucose readings in range, after controlling for potential confounding factors. Data were analyzed using analysis of covariance (ANCOVA) and regression analyses.

Results

Data from a total of 1411 One Drop users with type 2 diabetes and elevated baseline glucose were analyzed. Participants (60.6% male, 795/1311; mean age 50.2 years, SD 11.8) had diabetes for 7.1 years on average (SD 7.9). After controlling for potential confounding factors, blood glucose forecasts were associated with more frequent blood glucose logging (P=.004), lower average blood glucose (P<.001), and a higher percentage of readings in range (P=.03) after 12 weeks. Blood glucose logging partially mediated the relationship between exposure to forecasts and average glucose.

Conclusions

Individuals who received blood glucose forecasts had significantly lower average glucose, with a greater amount of glucose measurements in a healthy range after 12 weeks compared to those who did not receive forecasts. Glucose logging was identified as a partial mediator of the relationship between forecast exposure and week-12 average glucose, highlighting a potential mechanism through which glucose forecasts exert their effect. When administered as a part of a comprehensive mHealth program, blood glucose forecasts may significantly improve glycemic management among people living with type 2 diabetes.
Impact of COVID-19 Social Distancing Mandates on Gastrointestinal Pathogen Positivity: Secondary Data Analysis
Authors: Palmer Tanner , Benson L Scott , Porucznik Christina , Gren Lisa H
Published: May 2022

Background

Acute gastrointestinal (GI) illnesses are of the most common problems evaluated by physicians and some of the most preventable. There is evidence of GI pathogen transmission when people are in close contact. The COVID-19 pandemic led to the sudden implementation of widespread social distancing measures in the United States. There is strong evidence that social distancing measures impact the spread of SARS-CoV-2, and a growing body of research indicates that these measures also decrease the transmission of other respiratory pathogens.

Objective

This study aims to investigate the impact of COVID-19 social distancing mandates on the GI pathogen positivity rates.

Methods

Deidentified GI Panel polymerase chain reaction test results from a routinely collected diagnostic database from January 1, 2019, through August 31, 2020, were analyzed for the GI pathogen positivity percentage. An interrupted time series analysis was performed, using social distancing mandate issue dates as the intervention date. The following 3 target organisms were chosen for the final analysis to represent different primary transmission routes: adenovirus F40 and 41, norovirus GI and GII, and Escherichia coli O157.

Results

In total, 84,223 test results from 9 states were included in the final data set. With the exception of E coli O157 in Kansas, Michigan, and Nebraska, we observed an immediate decrease in positivity percentage during the week of social distancing mandates for all other targets and states. Norovirus GI and GII showed the most notable drop in positivity, whereas E coli O157 appeared to be least impacted by social distancing mandates. Although we acknowledge the analysis has a multiple testing problem, the majority of our significant results showed significance even below the .01 level.

Conclusions

This study aimed to investigate the impact of social distancing mandates for COVID-19 on GI pathogen positivity, and we discovered that social distancing measures in fact decreased GI pathogen positivity initially. The use of similar measures may prove useful in GI pathogen outbreaks. The use of a unique diagnostic database in this study exhibits the potential for its use as a public health surveillance tool.
Does Cyber-Dating Abuse Cause Trauma in College Students: An Online-Survey? (Preprint)
Authors: Schneider Raphaela , Eichenberg Christiane
Published: May 2022

BACKGROUND

With cyberspace making it possible to establish also romantic relationships, new possibilities as well as new problems arise. As each facete of social life is represented digitally nowadays, also dating and its downsides like cyber-dating abuse are. Prior research offers contradicting findings regarding forms, prevalence, and gender differences.

OBJECTIVE

The present study aimed on the one hand to explore cyber-dating abuse forms college students experience with their respective event-prevalence and gender differences regarding distress and the overall sum of critical events. Additionally, it explores the occurrence of post-traumatic stress following these events. On the other hand, this study tried to confirm the hypothesis that college students with and without suspected post-traumatic stress disorder (PTSD) differ in how many abuse-forms they experienced as well as in the height of self-reported distress associated with the abuse events. Last, it was a goal to confirm a supposed negative association of support and traumatic distress in connection with cyber-dating abuse.

METHODS

Data of 200 (mean age = 23.54, SD = 2.76, range = 18 to 33; gender: female (68%)/male (30.5%), response rate = 12.2) college students were collected via an online survey that used standardized questionnaires (IES-R for PTSD), own questions deduced from prior research, and distress ratings.

RESULTS

Unwanted sexual messages, ghosting, fake profiles are among the most common, sharing of own sexual photos, abuse of trust to obtain sex, sharing of secrets among the least common events. Gender differences for the overall sum of cyber-dating abuse events (t(137.60) = 3.57, P<.001) as well as for the overall distress (t(166.03) = -4.88, P<.001) following these events were found with women having higher values in both variables. Suspected PTSD (Prevalence=36.8 %) is most likely followed: cyberstalking, pressure for mailing own sexual photos, humiliation, and sharing personal secrets. First hypothesis was confirmed by showing significant differences in the sum of cyber-dating abuse events and in the height of the associated distress between college students with and without suspected PTSD.

CONCLUSIONS

High prevalence of suspected PTSD shows that dating abuse is not only in real life, but also in digital life, a serious issue. The fact that not only the amount of distress is relevant for developing a suspected PTSD, but also the total sum of events, indicates that every event including the common and at first glance less harmful events should be part of a preventive strategy. Since high prevalence rates were found at this young age, a general necessity for early education in the existence of cyber-dating abuse can be inferred. In addition, young student women should be in special focus for preventive measures and offers for counselling.
Effects of mobile mindfulness meditation on mental health of university students: Systematic review and meta-analysis (Preprint)
Authors: Zhu Chunqin , Yang Ting
Published: May 2022

BACKGROUND

Mobile mindfulness meditation (MMM) is mindfulness meditation intervention implemented by mobile devices like smart phones and apps. MMM has been used to help managing mental health of university students.

OBJECTIVE

The purpose of this study was to evaluate the effectiveness of MMM on mental health of university students in the areas of stress, anxiety, depression, mindfulness, well-being, and resilience.

METHODS

We conducted a systematic review and meta-analysis of the effectiveness of MMM on mental health of university students. An electronic literature search using the PubMed, Web of Science, EBSCO, Cochrane Library, and EMBASE from inception to July 16, 2021 was conducted to identify studies that reported the effects of MMM on stress, anxiety, depression, mindfulness, well-being, and resilience. Two reviewers retrieved articles, evaluated quality and extracted data independently. The methodological quality of the selected studies was determined using the Cochrane criteria for risk-of-bias assessment. The RevMan Version 5.3 was used to perform meta-analysis.

RESULTS

A total of 10 studies, including 958 university students, were selected for meta-analysis. Results showed that MMM was more effective than the control groups in decreasing stress (SMD=-0.41, 95% CI [-0.59, -0.23], P<0.0001), alleviating anxiety (SMD=-0.29, 95% CI [-0.50, -0.09], P=0.004), enhancing well-being (SMD=0.30, 95% CI [0.11, 0.50], P=0.003), and improving mindfulness (SMD=2.66, 95% CI [0.77, 4.55], P=0.006). However, there was no difference between MMM and the control groups in depression (SMD=-0.14, 95% CI [-0.30, 0.03], P=0.11), and resilience (SMD=-0.06, 95% CI [-0.26, 0.15], P=0.59).

CONCLUSIONS

MMM was an effective method to reduce stress, anxiety, and to increase well-being, mindfulness of university students, further studies are needed to confirm our findings.

CLINICALTRIAL

CRD42022303585; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=303585.
La ruta colonial de Potosí a Cobija y la vieja nueva praxis de modelos andinos mercantiles
Authors: García-Albarido Francisco
Published: May 2022

This article discusses colonial mercantile transport models on the Potosí-Cobija route in light of remaining evidence of native transport praxis. First, researchers use XVIII and XIX century documents to localize the route for subsequent remote sensing and archaeological survey. The results, including evidence of a system of traditional rest stops (pascanas) and shepherd settlements, suggest that native efforts played a crucial role in early mercantile flows. One commonality among native transport practices, even during Inca and Bourbon times, is their independence from any official road infrastructure. Thus, a system of inns testifies to the influence of the Spanish Enlightenment on the Potosí-Cobija route. While the route itself was the result of continuous flows of native people, its story reflects the fusion of mercantile and Andean transportation models and practices. Synthesis of archaeological and historical information suggests early colonial flows under Inca canons of roads and inns (tambos), followed by post-Toledo partial merchantilization with muleteers and mule trains, and Andean implementation of Bourbon dictates in the wake of Bolivian independence.
Enunciados ecoicos: concepto, funciones y relaciones ostensivo-inferenciales
Authors: Portillo Fernández Jesús
Published: May 2022

En este trabajo se analiza el concepto enunciado ecoico con el objetivo de comprender su origen y desambiguar su definición, así como examinar y ejemplificar su capacidad de generar contenidos implícitos (convencionales, no convencionales y sus respectivos subtipos) y de focalizar / enfatizar ideas previamente usadas en las interacciones comunicativas; además se aborda su versatilidad para realizar múltiples funciones discursivas. A partir de la revisión diacrónica de las principales investigaciones sobre ecoicidad y la creación de un corpus de ejemplos, se examinan sus fuentes discursivas (auto-repetición y alo-repetición), su relación con la voluntad y la intención, y su capacidad de producir presuposiciones, inferencias trópicas, implicaturas conversacionales generalizadas o particularizadas y sobreentendidos. Por último, se estudia la potencia funcional de los enunciados ecoicos para expresar, apelar, embellecer, mantener abierto el canal comunicativo, crear expresiones metalingüísticas, ironizar, conversar sarcásticamente, etcétera.
Hablantes de herencia: ¿una noción aplicable para los indígenas de México?
Authors: Mulík Stanislav , Amengual Mark , Maldonado Ricardo , Carrasco-Ortíz Haydée
Published: May 2022

Este trabajo evalúa si el concepto de hablantes de herencia (HH) —bilingües de lengua materna minoritaria y lengua dominante mayoritaria— es adecuado para describir la realidad lingüística de los bilingües indígenas en México, ámbito en el que no ha sido explorado cabalmente. Para este fin, se estudia el caso particular de los hablantes de hñäñho, otomí de Santiago Mexquititlán, que migraron y residen en distintas ciudades del país. En cinco trabajos académicos —realizados en los últimos veinte años— se identificaron rasgos prototípicos de HH en dicha población (uso del hñäñho como lengua familiar, grados de bilingüismo, competencia en la lengua mayoritaria, cambio de dominancia lingüística, entre otros), pero también aquellos aparentemente específicos del contexto bilingüe indígena mexicano (conflicto social, cultural y lingüístico, discriminación, mestizaje, castellanización), determinados por factores culturales, históricos y sociopolíticos. Con base en esta revisión, se propone el término hablantes de herencia indígena mexicana (HHIM), reconceptualización de la noción básica de HH, que busca reflejar la complejidad sociolingüística de dichos hablantes en la realidad mexicana.
Incertidumbre electoral y su impacto en la volatilidad del mercado de valores en México
Authors: Cazares Aguilar Jesús Alberto , Luna Dominguez Edgar Mauricio
Published: May 2022

Objetivo: Analizar el impacto de la incertidumbre generadasobre el ganador de las elecciones presidenciales en México en los rendimientos y volatilidad del Índice de Precios y Cotizaciones (IPC) de la Bolsa Mexicana de Valores (BMV) Diseño metodológico: Se calcularon medidas de incertidumbre electoral basadas en la distribución normal acumulada de las preferencias electorales, utilizando los resultados de encuestas publicadas por el Instituto Nacional Electoral (INE) previo a las elecciones presidenciales de 2006, 2012 y 2018 en México; se recopiló información diaria a cifras de cierre del IPC para medir el comportamiento del mercado bursátil. Para el análisis de los datos se utilizó un modelo de Heterocedasticidad autorregresiva condicional generalizada (GARCH, por sus siglas en inglés). Resultados: El análisis muestra que un aumento en la incertidumbre electoral incrementa la volatilidad del rendimiento del IPC en una elección muy competida, y que el avance en las preferencias electorales del candidato de ideología de izquierda genera una disminución en el rendimiento medio del índice, en tanto que,el avance del candidato de derechase relaciona con un aumento en el rendimiento. Limitaciones de la investigación:El estudio comprendetres periodos electorales debido a que la competencia con posibilidades reales de triunfo entre representantes de diversas ideologías políticas es reciente en el país. Hallazgos: El comportamiento del mercado de valores en México se ve afectado por el ciclo electoral presidencial, en especial, el grado de incertidumbre acerca del ganador y su ideología política, situación importante para considerar en la toma de decisiones económicas.
Precariedades, racialización e interseccionalidad. Segmentos y perfiles laborales de mujeres mapuche residentes en La Araucanía, Chile
Authors: Blanco Sepúlveda Osvaldo , Rain Rain Alicia , Julián Vejar Dasten
Published: May 2022

La racialización del trabajo de los pueblos indígenas es un tema de gran relevancia para entender la persistencia de las asimetrías y desigualdades coloniales en América Latina. El presente artículo propone un sistema de clasificación de segmentos y perfiles laborales en un grupo tradicionalmente invisibilizado: las mujeres mapuche residentes en la región de La Araucanía en Chile. Nuestra propuesta consiste en una tipología de siete perfiles construidos mediante un conjunto de variables laborales, demográficas y socioeconómicas. Comenzamos desarrollando la relevancia del presente estudio a través de una discusión entre diversos enfoques, incluyendo la precariedad, la interseccionalidad y la racialización. Posteriormente, exponemos los resultados de la combinación de análisis de correspondencias múltiples y clúster de k-medias. El artículo termina con definir los alcances y limitaciones de esta propuesta, así como las líneas de investigación y la discusión en política pública que se abre a partir de los resultados.
Convencionalidad y constitucionalidad. Los casos de México y España
Authors: López Guerra Luis
Published: May 2022

La existencia de normas internacionales sobre derechos humanos plantea el problema de cómo resolver la eventual incompatibilidad con las del ordenamiento interno. El caso de México ejemplifica la utilización del llamado “control de convencionalidad”, que puede resultar en la inaplicación de la norma doméstica en supuestos de contradicción irresoluble de su contenido con la norma convencional, interpretada por la jurisprudencia internacional. En línea distinta, en el caso español se prevé que la norma interna habrá de ajustarse a una interpretación de los mandatos constitucionales acorde con el ordenamiento convencional en materia de derechos humanos, lo que eventualmente podría dar lugar a la declaración de la norma legal interna como inconstitucional. El control de convencionalidad se ve así sustituido por un control de constitucionalidad.
Deliberación y soberanía popular en la reforma constitucional de Mendoza: en busca de la legitimidad
Authors: Giuffré Carlos Ignacio
Published: May 2022

En el proceso de reforma de la centenaria Constitución de Mendoza, el presente trabajo tiene por objeto explicitar las tensiones habidas al interior del constitucionalismo en los aspectos atinentes a la soberanía popular, el poder constituyente y el lugar del pueblo. Dentro de ese marco teórico, la hipótesis adoptada consiste en que la dificultad para materializar el cambio constitucional obedece a que los intentos se ciñen sólo a procedimientos legales, que no fueron diseñados para favorecer el intercambio democrático y discursivo de razones entre el Estado y el pueblo. Frente a esa problemática, el desarrollo de prácticas “extraconstitucionales”, que surgen de una teoría deliberativa de la democracia, contribuiría a dotar de legitimidad democrática la eventual reforma.
Gênero sob ataque: atravessamentos da suposta neutralidade política na pauta educacional brasileira
Authors: Valentim Brasil Marina , Cúnico Sabrina Daiana , Brandelli Costa Angelo
Published: May 2022

O presente artigo se propõe a discutir teoricamente de que forma os discursos relativos ao conceito de gênero e de sexualidade atravessam e são reproduzidos no que tange à pauta da educação no Brasil. Este trabalho parte da posição que a escola possui uma função política fundamental – a formação de cidadãos – embora também enfrente um momento de tentativa de controle de professores/as e currículos por parte de organizações político-partidárias conservadoras. A partir da literatura de gênero, argumentamos neste artigo teórico, que a escola deva ser um espaço em que temáticas como gênero, sexualidade, diversidade sexual, dentre outras, possam ser debatidas e problematizadas, uma vez que tais discussões contribuem para uma formação que estimula o pensamento crítico e a valorização da diversidade. Conclui-se que estimular o pensamento plural não é uma armadilha para desmantelar os lares e as famílias, como a realidade conservadora brasileira busca supor. Ao contrário, é contribuir para a formação de cidadãos/ãs comprometidos/as com um país menos desigual.
Experiências de uma Cidade com a Loucura
Authors: Monecchi Samara Pimenta , Barros de Barros Maria Elizabeth , De Barros Conde Rodrigues Heliana
Published: May 2022

A cidade de Cariacica-ES foi sede do primeiro hospital psiquiátrico público do estado - local que produziu marcas na memória de uma cidade, que se acostumou a manter a loucura à distância, trancafiada nos muros do manicômio. Com as lutas provenientes da Reforma Psiquiátrica, os manicômios tiveram seus muros abalados e a proposta de um cuidado territorial começou a ser posta em prática: a loucura passou a habitar outros espaços da cidade. O presente artigo foi construído a partir de uma experiência investigativa que teve como objetivo conhecer os modos como a loucura foi acolhida em Cariacica-ES para além do espaço manicomial, a partir dos Serviços Residenciais Terapêuticos, após a abertura dos muros físicos do antigo Hospital Adauto Botelho.
O Feminino e o Místico como identidade de Guiné-Bissau na poética de Odete Semedo “NO FUNDO DO CANTO”
Authors: Timbane Alexandre António , De Souza Antônia Valdilene Rocha
Published: May 2022

O lugar da mulher na cultura e nas tradições africanas, especialmente dos povos bantu tem sido um desafio, uma vez que por um lado temos a ancestralidade que se manifesta pela cultura e por outro a modernidade trazida pelo ocidente por meio da colonização ou da interação com  outros povos. Esta pesquisa tem como objeto  o estudo do livro “No Fundo do Canto” de Odete Semedo, com a finalidade de analisar a representação do feminino e do místico como identidade cultural  da Guiné- Bissau. Trata-se de uma pesquisa de abordagem qualitativa, com objetivo descritivo-exploratório e procedimento documental. Quanto aos procedimentos metodológicos identificamos trechos de nove poemas da obra “No Fundo do Canto” que remete ao feminino e ao místico como marcas da identidade da Guiné-Bissau através dos significados construídos por meio  da língua crioula, em especial.  O corpus foi analisado à luz dos teóricos do porte de Augel (2005), Hall (2006), Semedo (2011), Bâ (1982), Cá e Timbane (2021) e Manuel e Timbane (2018). Concluiu-se que a presença feminina está atrelada ao místico e remete ao poder feminino, como também demonstra características culturais de Guiné-Bissau, tendo a língua como propiciadora de  formações léxico-semânticos que remetem as culturas do país.
Pathology in Practice
Authors: Dolan Jacqueline K. , Jeon Albert B. , Hawkins Ian K. , Lanier Christopher J.
Published: May 2022

In collaboration with the American College of Veterinary Pathologists
Pathology in Practice
Authors: Cagle Laura A. , Sandoval Kamila , Wait Courtney S. , Porter Erin G. , Beatty Sarah S. K.
Published: May 2022

In collaboration with the American College of Veterinary Pathologists
Ruta chalepensis full extract and organic phases exhibit nematocidal activity against Haemonchus contortus eggs and infective larvae (L3)
Authors: Jasso-Díaz G. , Torres-Hernández G. , Zamilpa A. , Becerril-Pérez C.M. , Ramírez-Bribiesca J. E. , Hernández-Mendo O. , Sánchez-Arroyo H. , Olmedo-Juárez A. , González-Cortazar M. , Mendoza-De Gives P.
Published: May 2022

The ovicidal and larvicidal effect of a full aqueous extract (FE) and two phases: an aqueous (Aq-Ph) and an ethyl acetate (EtOAc-Ph) from Ruta chalepensis (Rc) stems and leaves against Haemonchus contortus (Hc) were assessed. The egg hatching inhibition (EHI) assay and larval mortality (LM) test were performed by triplicate in 96-well micro-titration plates (n=4 wells). The FE against Hc eggs and larvae was assessed at 1.25, 2.5, 5, 10 and 20 mg/mL; and 30, 60, 90, 120,150 and 200 mg/ mL, respectively. The ovicidal effect of Aq-F and EtOAc-F was assessed at 1.25, 2.5, 5, 10 and 20 mg/mL. Plates were incubated at 28 °C for 48 (ovicidal assay) and 72 h (larvicidal assay). The EHI results were considered based on the mean number of eggs hatching failure after 48 h exposure. The LM was recorded after 72 h exposure to the Rc phases and expressed as mortality percentage. The Rc FE caused 96 and 100% EHI at 10 and 20 mg/mL, respectively; meanwhile, 74% LM was recorded at 200 mg/mL (p<0.05). The Aq-Ph showed 78.5% EHI at 2.5 mg/mL. Likewise, the EtOAc-Ph caused 100% EHI in almost all concentrations. Eighteen compounds including alkaloids, cumarins, triterpens, flavonoids, tannins, saponins and sterols were identified by GC-MS analysis. The results indicate that the aqueous extract from Rc possesses bioactive compounds with in vitro nematocidal activity against Hc; mainly in the EtOAc-Ph. Further studies should be performed to elucidate those compounds searching for alternative methods of control of the sheep haemonchosis.
Parasite community analysis of the gray snapper Lutjanus griseus (Perciformes,Lutjanidae) in a tropical region of the Southern Gulf of Mexico
Authors: Rodríguez-Santiago M. A. , Ramos-Colorado L. , García-Magaña L. , Grano-Maldonado M.I. , Iannacone J. , Vázquez-Caballero A.
Published: May 2022

The gray snapper Lutjanus griseus is a commercially important fish species along its distribution range in the western Atlantic Ocean. However, despite its importance, there is still little knowledge about its parasitic fauna for the Mexican coasts of the Gulf of Mexico. The aims of this research were to generate a list of the parasitic fauna present in juvenile gray snapper L. griseus from a coastal lagoon located in southeastern Mexico, to evaluate the infection levels of parasites and to determine the relationship between the abundance of parasites and the fish size and condition factor. Samples of L. griseus (12 – 29.2 mm) were obtained in two periods of the year (dry and rainy seasons) to examine the intra-annual variability of its parasitic fauna. A total of 17 parasite species were recorded belonging to six taxonomic groups (Myxozoa, Monogenea, Digenea, Cestoda, Nematoda and Acanthocephala). The highest levels of infection (abundance, prevalence and intensity of infection) were found for the monogeneans Euryhaliotrema griseus and Euryhaliotrema fastigatum. There were no significant correlations between the total abundance of parasites and the fish condition and size (total length) in not any of the two seasons studied, suggesting that the body size and the biological condition index of the host did not directly influence the abundance of parasites in early life stages of L. griseus. Moreover, the species of parasites found that could be zoonotic for humans through the consumption of raw or inadequately cooked fish were the nematodes Contracaecum sp. type 1, Contracaecum sp. type 2, Cucullanus pargi and Pseudoterranova sp. The presence of the monogeneans E. griseus and E. fastigatum was also highlighted because these ectoparasite species are known to cause harm to fish under culture systems. All the parasite species found in this study, except nematodes, were new records of geographic distribution.
New data on pipefishes’ and seahorse’s endohelminths off Crimean coasts of the Black Sea
Authors: Kornyychuk Y. , Polyakova T. , Pronkina N.
Published: May 2022

A total of 357 Syngnathidae fishes (Syngnathus abaster Risso, 1827, S. typhle Linnaeus, 1758 and Hippocampus hippocampus (Linnaeus, 1758) caught in different habitats along Crimean Black Sea shelf were examined for presence of endohelminths and revealed to be hosts of 15 helminth species. The fishes are second intermediate hosts for five “birds’” digenean species and nematodes (larvae of three species and immature adults of one more species) completing life-cycles in waterbirds and fish; for two acanthocephalans and three cestodes larvae ending development in fish. We suggest, basing on data on feeding of the Black Sea predatory fish and waterbirds, that Syngnathid fishes are paratenic hosts in parasitic systems of most cestodes, nematodes and acanthocephalans. All the trematodes found are generalists at metacercarial stage; specialists Timoniella imbutiformis and Aphallus tubarium use Syngnathidae as definitive hosts. Cestodes, nematodes as well as acanthocephalans found are generalists, too. Based on infection indices, S. typhle are main final host and H. hippocampus are main 2nd intermediate hosts for T. imbutiformis; Syngnathids are accidental hosts for other trematodes as well as for all the cestodes, nematodes and acanthocephalans. Cryptocotyle concava and Pygidiopsis genata are important as Syngnathid fishes’ threats, especially in marine protected aquatoria, being potential agents of “black spot disease”.
Ligula intestinalis infection in a native Leuciscid hybrid (Alburnus derjugini x Squalius orientalis) in the Kürtün Dam Lake, Northeast Anatolia
Authors: İpek Z. Z. , Kaya C. , Kayiş Ş.
Published: May 2022

Taxonomic evaluations are needed to accurately determine the host selection of fish parasites. The present study is a multidisciplinary research in the field of basic and fish diseases sciences. The description of the hybrid species of Squalius orientalis and Alburnus derjugini and infection of Ligula intestinalis in these hybrid fish were reported for the first time from the Kürtün Dam Lake in northeast Turkey. A total of 450 fish were sampled in March, August, and October in 2020 using gillnets. Detailed morphological characteristics (n = 24) were compared to determine the difference among ancestors and hybrid species. The prevalence of L. intestinalis between the sampling periods and the size groups of fish (0 – 10, 11 – 15, and ≥16 cm in length) were examined. Moreover, the highest prevalence of the parasite was observed in October (78.94 %), with a size range of 0 – 10 cm in length (77.8 %). In addition, the total prevalence of the parasite was 48.44 %. The results revealed that most of the diagnostic metric and meristic features of hybrid fish were ranging between the data of S. orientalis and A. derjugini. According to previous reports, when hybrid individuals were compared with their ancestors in terms of prevalence, hybrid individuals were more susceptible to L. intestinalis infections. This study was unique as it provided the first record of L. intestinalis in a hybrid fish population.
Religious Populism in Mainstream Media between Indonesia and India
Authors: Kansong Usman , Sunarwinadi Ilya Revianti , Triputra Pinckey
Published: May 2022

Introduction: The mainstream media used political and media logic on religious populism to reinforce ideological changes in contemporary society. This study investigated how media mediatize the 212 rally (aksi 212) and the 2017 Jakarta Governorial Election as religious populism cases. This study also compared how media in Indonesia and India delivered the content based on the majority identity.

Methods: This study applied a qualitative approach. Detik.com, Metro TV, and Republika Daily were selected based on their delivery content platform and media ownership. The qualitative content analysis was applied to explore the concepts of political and media logic. Then, the results of Islamic populism in Indonesia were compared with Hindu populism in India.

Findings: This study found that the three media mediatized aksi 212 and the 2017 Jakarta Governorial Election as religious populism by using direct interaction. Detik.com was applying media logic while Metro TV and Republika Daily performed political logic. In comparing religious populism between Indonesia and India, the finding confirmed that populism came from a major identity. The finding showed that economic motivation could be escalated in parallel with religious identity.  
Originality: This study become a novelty since no previous studies investigate the different delivery content platforms and the media ownership including comparing the mediatization process between two countries. Previous studies focused on the media concentration based on media ownership, platform, media landscape, and media policy without a mediatization process and religious populism. The previous studies of the mediatization of religious populism were conducted in a single case.
Sistemas de información para la salud: un análisis del diseño desde la perspectiva de las políticas públicas
Authors: D’Agostino Marcelo , Marti Myrna C , Jaime Fernando , Garcia Saiso Sebastian
Published: May 2022

En 2019, la Organización Panamericana de la Salud aprobó una política regional conocida como Plan de acción para el fortalecimiento de los sistemas de información para la salud 2019-2023, cuyo diseño es el objeto de este artículo. El análisis se realiza tanto desde el punto de vista de su elaboración como de la implementación, a la luz de los conceptos teóricos de Harold Lasswell y Charles Lindblom. El siguiente estudio de política se realizó a partir de una reflexión sobre su contexto, orientación hacia problemas, diversidad y multiplicidad de los métodos utilizados. Asimismo, se hizo una reflexión sobre la búsqueda imparcial del interés público, el diseño de políticas prácticas, la satisfacción de las necesidades de los funcionarios públicos y la oferta de recomendaciones. La política puede ser implementada independientemente de la configuración administrativa de los países y territorios o bien del poder político que puedan ejercer otras instituciones. Su diseño está orientado al acceso universal a los servicios de salud para la región de las Américas, teniendo en cuenta la diversidad cultural e idiomática, incluyendo poblaciones indígenas demuestra que se contextualizó para una región con altos índices de inequidades.
Influence of addition of butadiene copolymer and modified styrene on the mechanical behavior of a sand
Authors: Barreto Thiago , Repsold Lucas , Souza e Silva Nathália , Casagrande Michéle
Published: May 2022

Butadiene-styrene copolymer (SBR) is an elastomer composed of 75% butadiene and 25% styrene and is widely used in the automotive industry in tire production. This elastomer can be produced from two polymerization processes: emulsion or solution polymerization. This paper presents the mechanical behavior of a polymer reinforced sand compared to pure sand. Direct shear tests were performed on pure sand specimens and with the addition of modified styrene butadiene-styrene copolymer (XSBR). The polymeric sand specimens had 10% moisture content, 50% relative density, with water-polymer mass ratios of 1:1, 1:2, and 1:4, with no curing time, or with curing times 48, 72, 96, 576, and 720 h. Improvements were verified in the strength parameters of sand specimens with polymer addition, while comparing with pure sand parameters, showing that the improvement of soils with polymers is satisfactory for application in geotechnical works, such as: embankments in soft soils, soils for shallow foundations and for slope stability.
CONSTRUCTION AND VALIDITY OF THE ADAPTATION LEVEL SCALE OF THE PERSON WITH OSTOMY
Authors: Medeiros Lays Pinheiro de , Xavier Suênia Silva de Mesquita , Freitas Luana Souza , Silva Isabelle Pereira da , do O Lorena Brito , Lucena Silvia Kalyma Paiva , Silva Renan Alves , Costa Isabelle Katherinne Fernandes
Published: May 2022

Objective: To construct and validate the content of the scale for verifying the level of adaptation of the person with ostomy. Method: Methodological study involving two stages: construction based on two integrative literature reviews and qualitative study with people with stomas; and content validity with judges of the following criteria: behavioral, objectivity, relevance, clarity, simplicity, variety in relation to language; carrying out the pilot test with the target group; lexical and grammatical correction and resubmission to the content validity index. Results: in the first stage, thirteen items received suggestions for improvement, three items were unified by similarity and one was excluded. After the adjustments, a consensus was reached among the judges regarding the representativeness of the items and permanence in the modes based on the evaluated criteria. The target population judged the items as easy to understand, followed by grammatical and lexical correction. Conclusion: The scale presented evidence of content validity demonstrating consensus between the judges and the population.
CONSTRUÇÃO E VALIDADE DA ESCALA DO NÍVEL DE ADAPTAÇÃO DA PESSOA COM ESTOMIA
Authors: Medeiros Lays Pinheiro de , Xavier Suênia Silva de Mesquita , Freitas Luana Souza , Silva Isabelle Pereira da , do O Lorena Brito , Lucena Silvia Kalyma Paiva , Silva Renan Alves , Costa Isabelle Katherinne Fernandes
Published: May 2022

Objetivo:Construir e validar o conteúdo da escala de verificação do nível de adaptação da pessoa com estomia. Método: Estudo metodológico envolvendo duas etapas: construção baseada em duas revisões integrativas da literatura e estudo qualitativo com pessoas com estomia; e validade de conteúdo com juízes dos seguintes critérios: comportamental, objetividade, relevância, clareza, simplicidade, variedade em relação à linguagem; realização do teste-piloto com o grupo-alvo; correção léxica e gramatical e nova submissão para o índice de validade de conteúdo. Resultados: Na primeira etapa, treze itens receberam sugestões de melhoria, três itens foram unificados por similaridade e um foi excluído. Após os ajustes, alcançou-se consenso dos juízes quanto à representatividade dos itens e à permanência nos modos a partir dos critérios avaliados. A população-alvo julgou os itens como de fácil entendimento ocorrendo em seguida correção gramatical e lexical. Conclusão: A escala apresentou evidência de validade de conteúdo demonstrando consenso entre os juízes e a população-alvo.
Odontologia para Pacientes com Necessidades Especiais
Authors: Andrade Raphael Victor Silva , Santos Sophia Queiroz Marques dos , Roncalli Ângelo Giuseppe , Galvão Maria Helena
Published: May 2022

O estudo objetivou analisar as estruturas curriculares dos cursos de Odontologia da região Nordeste e investigar a presença do componente curricular Odontologia para Pacientes com Necessidades Especiais (OPNE). Trata-se de um estudo seccional, descritivo e quantitativo. Os dados foram coletados entre junho e dezembro de 2020 no sítio eletrônico do Ministério da Educação (e-MEC) e nos portais das instituições de ensino identificadas, com análise das estruturas curriculares dos cursos. Havia 138 cursos de Odontologia autorizados e cadastrados na plataforma e destes, sete foram excluídos por ausência de portal atualizado ou por ainda não ter formado pelo menos uma turma. Dos 131 cursos de graduação em Odontologia analisados, verificou-se que 62 IES (47,30%) ofertavam o componente OPNE, dentre as quais 53 (40,50%) o ofertavam como componente obrigatório. O estado da Paraíba apresentou a maior frequência (n=13, 86,7%) de cursos que ofertam o componente curricular, enquanto o estado de Sergipe obteve a menor frequência (n=1, 16,7%). Conclui-se que o componente curricular OPNE é pouco ofertado nos cursos de graduação em Odontologia na região Nordeste, o que pode impactar diretamente na capacitação dos profissionais para prestar um melhor cuidado de saúde bucal para essa população.
Kajian Sistem Penilaian Portofolio Berdasarkan Kompetensi Pedagogik Guru
Authors: Jannah Miftahul , Na’imah Na’imah
Published: May 2022

Kompetensi pedagogik harus dimiliki oleh setiap guru, termasuk para guru RA Rumah Kreatif Wadas Kelir Purwokerto. Penelitian ini dilakukan untuk menganalisis implementasi sistem penilaian portofolio berdasarkan kompetensi pedagogik guru di RA Rumah Kreatif Wadas Kelir serta dampak positif dan negatifnya. Penelitian ini dilakukan dengan pendekatan kualitatif deskriptif, dan teknik pengumpulan data melalui observasi, dokumentasi, dan wawancara. Teknik analisis dilakukan secara induktif; reduksi, display data, dan verifikasi. Hasil penelitian menunjukan bahwa: (1) Sistem penilaian portofolio diimplementasikan berdasarkan kompetensi pedagogik oleh para guru di RA Rumah Kreatif Wadas Kelir Purwokerto. Kompetensi pedagogik meliputi penguasaan ilmu pendidikan, pemahaman dan pengembangan potensi peserta didik, perencanaan dan pelaksanaan pembelajaran, serta sistem evaluasi pembelajaran. (2) Dampak positif atas implementasi penilaian portofolio berdasarkan kompetensi pedagogik disediakan berbagai media yang mendukung terlaksana kegiatan penilaian. (3) Dampak negatifnya, sebagian besar SDM tidak memiliki kualifikasi akademik guru PAUD