bluuebunny/crossref_metadata_2025 huggingface dataset:
A BIDIRECTIONAL ENCODER-DECODER MODEL WITH ATTENTIONMECHANISM FOR NESTED NAMED ENTITY RECOGNITION
Authors:   Ecole Doctorale Polytechnique, Institut National Polytechnique (INP-HB), Yamoussoukro, Cote dIvoire., Adama Samassi ,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT)., Konan Marcellin Brou ,   Ecole Doctorale Polytechnique, Institut National Polytechnique (INP-HB), Yamoussoukro, Cote dIvoire.,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT)., Appoh Kouame ,   Ecole Doctorale Polytechnique, Institut National Polytechnique (INP-HB), Yamoussoukro, Cote dIvoire.,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT)., Kidjegbo Augustin Toure ,   Ecole Doctorale Polytechnique, Institut National Polytechnique (INP-HB), Yamoussoukro, Cote dIvoire.
Published: April 2024

Named entity recognition is a fundamental task for several natural language processing applications. It consists in identifying mentions of named entities in a text, then classifying them according to predefined entity types. Most labeling methods for this task use a label to recognize flat named entities because they belong to a single entity type. Therefore, they cannot recognize named entities that belong to multiple entity types.In this work, we concatenated all the labels of a word of a named entity into a joint in order to recognize flat or nested named entities. Then, we proposed a bidirectional encoder-decoder model with attention mechanism that uses this joint label to fine-tune a pre-trained language model for named entity recognition.We experimented our method on GENIA (a nested named entity dataset) and on two flat named entity datasets: CoNLL-2003 and i2b2 2010. Using the BioBERT model, our method achieved an F1 score of 78.85% on the GENIA dataset, 93.22% and 87.51% on CoNLL-2003 and i2b2 2010 respectively. These results show that our method can effectively recognize flat named entities as well as nested named entities.
Geç Roma – Erken İmparatorluk Dönemi Onurlandırılmış Çıplak Hermes Tipleri: Yenilenen ve Yinelenen Romalılar
Authors: Cosar Guler Dogus
Published: April 2024

Hellen dünyasında çıplaklık sembolik bir anlam taşımaktaydı. Çıplak erkek vücudu güzellik, gençlik, cesaret, savaşta güçlü, sporda yenilmez ve hızlı olmanın bir göstergesi olarak bilinmekteydi. Romalılar ise Cumhuriyet Dönemi’nden itibaren Romalı kıyafetleri olan toga ile betimlenmiş olsalar da Roma dışında bulunan eyaletlerde toga yerine Hellenler için bahsi geçen ya da bilinen “sembolik çıplaklık” içeren onur heykel tiplerinde tasvir edilmişlerdir. Bir Romalı için çıplaklık sıra dışıdır. Bu nedenle, Romalıların günlük hayatta belli bir kıyafet yönetmeliğine göre hareket ettiği bilinirken, kimi zaman hayattayken kimi zaman ölümlerinin ardından neden kendilerini çıplak gösteren onur heykellerini tercih ettiklerinin sorgulanması gerekmektedir. Bu sorgulama ve sorgu sonucu uzun bir değerlendirme kısmı ile birlikte makalede yapılmıştır. Bu değerlendirme, metinde mevcut daha önce yayımlanmış arkeolojik materyaller ile veya yayınlar aracılığıyla ele alınmıştır. Bunun nedeni bu makalede bilinen tipler üzerinden Roma’nın Hellenler ile çıplak tipteki erkek heykellerinin etkileşimini daha net görebilmek için yapılmıştır. Araştırma boyunca üç ayrı Hermes tipinde toplam yedi adet onur heykelleri kendi tipleri altında incelenmiştir. Hermes tipleri sırasıyla “Hermes Farnese”, “Hermes Richelieu” ve “Sandaletini Bağlayan Hermes” şeklinde ana başlıklar halinde araştırılmıştır.

Her onur heykeli, dahil edildiği grubun altında gerek farklılıklarıyla gerekse benzerlikleri ile birlikte ele alınmıştır. Çalışmanın amacı, Hellenlerden itibaren Roma’nın Geç Cumhuriyet Dönemine doğru giriş yapıldığında bu dönemden itibaren değişen erkek onur heykel tiplerini saptamak ve karşılaştırmasını yapmaktır. Hem incelenen heykel tiplerinin sınıflandırılması adına hem de tiplerin altında incelenen erkek onur heykellerinin daha kolay anlaşılabilmesi için de heykeller gruplandırılmıştır. Her tip kendi grubu altında kronolojik olarak araştırılmış ve tiplerin önemi, değişimiyle birlikte ele alınmıştır. Yalnız Romalılar için onur heykeli denildiğinde akıllara sadece çıplak heykeller gelmemelidir. Çıplak tipler haricinde, yarı çıplak, giyimli ve zırhlı onur heykelleri de mevcuttur ancak başlıkta ve metinde sadece bu tip üzerinden bir değerlendirmeye gidilmiştir. Bu çalışma bir derleme olup, geniş bir değerlendirme ile sonlandırılmıştır.
İstanbul’un Fethi’nin 500. Yıldönümü Kutlamaları ve Muğla Basınına Yansıması
Authors: Akça Bayram
Published: April 2024

1453 yılında İstanbul’un Fatih Sultan Mehmet tarafından fethedilmesi Türk ve dünya tarihi için bir dönüm noktası olmuştur. Bu fetih II. Meşrutiyet’ten itibaren çeşitli şekillerde kutlanmaya başlanmıştır. Nitekim 1914 yılında İstanbul’un fethi ilk defa büyük bir törenle kutlanmıştır.

1939 yılına gelindiğinde Cumhurbaşkanı İsmet İnönü’nün talimatıyla 1953 yılında kutlanacak olan İstanbul’un fethinin 500. Yıldönümü için hazırlılar başlamıştır. Bu bağlamda 1941 yılında Milli Eğitim Bakanı Hasan Ali Yücel başkanlığında bir komisyon kurulmuştur. 1950 yılında ise Demokrat Parti’nin iktidara gelmesinden kısa bir süre önce Cumhuriyet Halk Partisi tarafından İstanbul’un fethinin 500.Yılı kutlamaları için “İstanbul’un Fethinin 500. Yılı ve Müteakip Fetih Yıllarını Kutlama Derneği” adıyla bir cemiyet kurulmuştur. Bu cemiyet maddi zorluklara rağmen Demokrat Parti döneminde de İstanbul’un 500. fetih yılı kutlama hazırlıklarına devam etmiştir.

29 Mayıs 1953 tarihinde İstanbul’da “İstanbul’un Fethinin 500. Yılı ve Müteakip Fetih Yıllarını Kutlama Derneği”, fethin 500. yılı nedeniyle on gün boyunca bilimsel, kültürel ve sanatsal birçok etkinlik düzenlenmiştir. Bu etkinliklere halk yoğun ilgi göstermiştir. Ancak bu törenlere Cumhurbaşkanı Celal Bayar ve Başbakan Adnan Menderes’in iştirak etmemesi dernek yönetimi ve halkta bir burukluğa neden olmuştur. Bu olayı dönemin basını da sert bir şekilde eleştirmiştir.

İstanbul’un 500. fetih yılı etkinlikleri İstanbul’da olduğu gibi Muğla İlinin Milas İlçesi’nde de yapılmıştır. Bu dönemde Muğla’da çıkan “Muğla’da Demokrat Yayla Gazetesi” hem İstanbul’da hem Muğla’da hem de yurtdışında fetihle ilgili yapılan tüm etkinlikleri okuyucusuna günü gününe aktarmıştır.
Nanoemulsions a Delivery System in the Making for Tumor Targeting
Therapeutics: Evaluation and Characterization to Meet Clinical Challenges
Authors: Shankar Ravi , Upadhyay Prabhat Kumar , Kumar Manish
Published: April 2024

Cancer is a complex disease characterized by the uncontrolled and unregulated growth
of cells followed by invasion and proliferation from the site of origin to other sites of the body.
Conventional chemotherapy largely kills rapidly expanding and dividing cancer cells by impairing
DNA synthesis and mitosis. It is associated with various types of adverse effects ranging
from simple nausea and appetite loss to serious ones like bone marrow depression and compromised
immunity etc., due to their non-selectivity and inability to differentiate. The ideal feature
of a delivery system is delivering the drug to the target place to achieve the most therapeutic
impact while having the least toxicity. With the advent of novel drug delivery systems, it has
been easier to deliver the drug to the target site. Utilizing new techniques and technology makes
it a feasible approach to target cancer cells. Nanoemulsions are isotropic mixtures of transparent
or translucent oil globules dispersed in an aqueous phase that is kinetically stable and supported
by an interfacial coating of surfactant and co-surfactant molecules with droplet sizes in the nanometre
range. Nanoemulsions are the delivery system of choice in case of cancer because of
certain key attributes, including biodegradability, biocompatibility, large surface area nonimmunogenicity,
and release behavior control. At the same time, nanoemulsions have been engineered
for various reasons, including enhanced biological half-life, target-specific binding ability,
and imaging capability at different therapy levels by modifying the characteristics of
nanoemulsions. This review focuses on current cancer treatment challenges and the role of
nanoemulsions in treating cancer with their production methods, characterization methods, application,
and quality attributes, which would help them make it to the clinics where cancer
treatment is going on.
A Review of the Medicinal Value and Chemical Composition of Flavonoids from Pongamia Pinnata: Recent Work in Drug Advancement and Therapeutics
Authors: Satapathy Trilochan , Kumar Yogesh , Pandey Ravindra Kumar , Shukla Shiv Shankar , Bhardwaj Shiv Kumar , Gidwani Beena
Published: April 2024

Traditional medicine in many countries, including those where Pongamia pinnata (L.)
Pierreis grown, uses the plant for a wide variety of purposes, including the treatment of piles, skin
problems, and wounds. The objective of the present study was to discuss the medicinal value and
chemical composition of flavonoids obtained from P. pinnata. All parts of the plant contain several
phytoconstituents responsible for biological activity. These compounds include numerous types of
flavonoid derivatives, such as flavones and flavans, as well as terpenes, steroids, and fatty acids. The
information required about the plant and advancement in therapeutics was gathered from Pubmed,
ScienceDirect and Cochrane Library. Many different types of biological activity, including antioxidant,
antibacterial, anti-inflammatory, and anti-diabetic properties, have been observed in plant products
from this species in pharmacological research. However, more research into the plant's phytochemical
profile and the complicated pharmacological effects is required. This is because our current
understanding of the plant's chemical ingredients and the methods by which they exhibit certain biological
activities is limited. Thus, information regarding active constituents is required to develop
novel therapeutics and additional research on the toxicity of the other chemicals identified from this
plant is necessary.
Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol),
Individually and in Combination with Curcumin, on Peripheral Blood
Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients
Authors: Fasihi Mahdieh , Samimi-Badabi Mahsa , Robat-Jazi Behrouz , Bitarafan Sama , Moghadasi Abdorreza Naser , Mansouri Fatemeh , Yekaninejad Mir Saeed , Izad Maryam , Saboor-Yaraghi Ali Akbar
Published: April 2024

Objectives:

Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease affecting the central nervous system. Immune cell subsets, notably T helper (Th) 17 and Th1, exert important roles in MS pathogenesis. Whereas, Treg cells modulate the disease process. Calcitriol, the active form of vitamin D, and curcumin, a bioactive compound derived from turmeric, play immunomodulatory effects relevant to autoimmune disorders, including MS. The objective of this study is to investigate the effects of calcitriol and Curcumin on Peripheral blood mononuclear cells (PBMCs) of individuals with MS.

Methods:

PBMCs from twenty MS patients were isolated, cultured, and exposed to 0.004 μg/mL of calcitriol and 10 μg/mL of curcumin. The cells underwent treatment with singular or combined doses of these components to assess potential cumulative or synergistic immunomod-ulatory effects. Following treatment, the expression levels of genes and the cellular population of Treg, Th1 and Th17 were evaluated using Real-time PCR and flow cytometry.

Results:

Treatment with curcumin and calcitriol led to a significant reduction in the expression levels of inflammatory cytokines and transcription factors related to Th1 and Th17 cells, including IFN-γ, T-bet, IL-17, and RORC. Furthermore, the frequency of these cells decreased following treatment. Additionally, curcumin and calcitriol treatment resulted in a significant upregulation of the FOXP3 gene expression and an increase in the frequency of Treg cells.

Conclusion:

This study demonstrates that curcumin and calcitriol can effectively modulate the inflammatory processes intrinsic to MS by mitigating the expression of inflammatory cytokines by Th1 and Th17 cells while concurrently enhancing the regulatory role of Treg cells. Moreover, the combined treatment of curcumin and calcitriol did not yield superior outcomes compared to single-dosing strategies.
Problemas na tradução automática do clítico vs. tradução humana do Espanhol para o Português Europeu
Authors: Almeida Andreia
Published: April 2024

The present work aims to identify and analyze problems in the automatic translation of the clitic pronoun from Spanish into European Portuguese in some sentences. Although this topic of syntax has already been studied in several scientific articles, what we propose is a rigorous and descriptive analysis of this problem, starting with the translation of a technological program, with the aim of understanding the version proposed by automation.
Armando de Almeida. Lição de Resistência na Cultura de Corrida Portuguesa
Authors: Camanho Luís , Carneiro José , Marques Susana Lourenço
Published: April 2024

Em março de 1913, Armando de Almeida venceu a maratona da “Semana Desportiva” do jornal O Mundo. Em maio do mesmo ano repetiu a proeza ao vencer a maratona dos Jogos Olímpicos Nacionais, na altura, a mais importante competição de atletismo no país. Por essas vitórias, é considerado o campeão nacional da maratona para o ano de 1913 pela Federação Portuguesa de Atletismo. Recordemos que a Federação Portuguesa de Atletismo só existe formalmente desde 1921. É, conjuntamente, num contexto de grande perturbação político-social e num ecossistema elitista, programaticamente desestruturado, que Armando de Almeida se destaca do grupo matricial de atletas que tomavam parte nestas novas formas de lazer e demonstrações de cultura de massas — as corridas pedestres de longa distância. A sua presença ativa na cultura de corrida da metrópole é contemporânea com a origem e constituição do movimento negro (1911–1933) — pioneiro no combate político antirracista em Portugal.
Neste texto, que tem como ponto de partida o resgate de fotografias e narrativas dos primórdios da história e da memória do atletismo português, procuramos biografar Armando de Almeida, num exercício simultâneo de empatia e militância como contributo para o debate, contrariando invisibilidades consequentes de negligências historiográficas. Tentamos, também, reconstituir a possibilidade de articulação entre os percursos emancipatórios do atleta com a organização de movimentos políticos e sociais no tumultuoso momento histórico da Primeira República, numa capital de império colonial, com expressiva presença de pessoas afrodescendentes, esse fenómeno histórico plurissecular.
Schetsboek van een treinreiziger
Authors: Loopmans Maarten
Published: April 2024

Perfectionisme is geen deugd als het op reizen aankomt. Wie van A(ntwerpen) naar Z(ebbug) wil zonder vliegen, moet kunnen improviseren en relativeren. 'Be like water', en je laveert rond vertragingen, buigt als riet voor gemiste aansluitingen om meanderend doorheen Europa een alternatieve route te vinden. 
De toekomst van het Europese spoor
Authors: Ghesquiere Noor , Beckers Caroline
Published: April 2024

(Hogesnelheids)treinen worden vaak voorgesteld als een goed alternatief voor de huidige verkeerssituatie en corresponderende problemen. Toch is het spoor geen eenvoudige oplossing. Het Europese spoorwegennetwerk bestaat namelijk uit een onsamenhangend lappendeken van nationale netwerken. Een Single European Railway Area moet hiervoor een oplossing bieden, maar ook dit stuit op moeilijkheden.
Vervoersgerichte ruimtelijke ontwikkeling
Authors: Blondia Matthias , De Block Greet
Published: April 2024

Ons diffuus verstedelijkingspatroon is een probleem dat voorvloeit uit de wisselwerking tussen mobiliteit en ruimtelijke ontwikkeling. TOD (Transit Oriented Development) is de oplossing die gebruik maakt van diezelfde dynamiek. Conceptueel helder, maar blijft dat zo als TOD concreet wordt in de Vlaamse nevelstad?
Sociale infrastructuur tegen eenzaamheid
Authors: Brink Julia , van Lanen Sander , Meijering Louise
Published: April 2024

Sociale infrastructuur biedt de ruimte om mensen te ontmoeten. Daardoor kan eenzaamheid voorkomen en ingeperkt worden. De vraag is in hoeverre de invulling van deze ruimte bij aanleg vastgelegd moet worden en in hoeverre er een organische invulling mag ontstaan.
Infographic Spoor
Authors: Van Oproy Ken
Published: April 2024

Netwerkkaart België
Mammillaria ariasii (Cacteae, Cactaceae), una nueva especie del Bajío y regiones adyacentes, México
Authors: Aquino David , Guzmán Ulises , González-Zamora Pedro , Sánchez Daniel
Published: April 2024

Antecedentes y Objetivos: Mammillaria es uno de los géneros más representativos de Cactaceae. En la región del Bajío, México, se distribuyen aproximadamente 70 especies y nueve subespecies, de las cuales siete especies y una subespecie corresponden a M. ser. Leucocephalae. En exploraciones recientes se encontraron individuos cuya morfología no concuerda con las especies descritas en los tratamientos taxonómicos actualizados. El objetivo de este trabajo es caracterizar y describir una nueva especie, con base en evidencia morfológica y medioambiental.
Métodos: Se realizó trabajo de campo en junio de 2022. Se analizaron mediante el Análisis Canónico Discriminante (ACD) siete caracteres morfológicos. Además, se calcularon los residuos de Pearson para dos variables medioambientales y la significancia se estimó con una prueba de bondad de ajuste chi-cuadrada. El área de ocupación y la extensión de ocurrencia se calcularon para asignar la categoría de conservación según los criterios y categorías de la Lista Roja de la IUCN.
Resultados clave: Se describe e ilustra a Mammillaria ariasii, similar a Mammillaria hahniana, de la cual difiere por el número de espinas radiales, la longitud de la espina central inferior y el color de los tépalos internos del perianto. La presencia de cristales extracelulares confirma su inclusión en M. ser. Leucocephalae. Mammillaria ariasii se caracteriza por habitar en suelos kastanozems háplico y relieves volcánicos en un área de ocupación aproximada de 28 km2 y de extensión de ocurrencia de 345 km2. Se proporciona una clave de identificación en donde se compara con otros miembros de Mammillaria ser. Leucocephalae.
Conclusiones: Mammillaria ariasii es una nueva especie endémica del Bajío. De acuerdo con nuestros resultados debe ser considerada como especie en peligro (EN). Si bien es localmente abundante, debe tenerse en cuenta la erosión y la ganadería como factores potenciales de riesgo.
ANALISIS KEMAMPUAN LITERASI LINGKUNGAN SISWA SEKOLAH ADIWIYATA MANDIRI
Authors: Al-Hilmiyah Nur Al-Azizah , Suhartini Suhartini
Published: April 2024

Kurangnya kepedulian masyarakat terhadap lingkungan menyebabkan berbagai masalah lingkungan yang terus dibiarkan. Solusi untuk permasalahan lingkungan datang dari semua sektor, terutama pendidikan. Solusi tersebut diimplementasikan melalui kegiatan adiwiyata. Keberadaan sekolah adiwiyata diharapkan dapat mengembangkan literasi lingkungan siswa. Tetapi kenyataannya tidak semua sekolah adiwiyata memiliki tingkat literasi lingkungan yang sangat baik dan dapat menjamin sepenuhnya peningkatan literasi lingkungan di kalangan siswa. Penghargaan tertinggi untuk sekolah adiwiyata adalah adiwiyata mandiri. Salah satu SMA Negeri di Kabupaten Sleman yang berada di kaki Gunung Merapi berhasil meraih penghargaan tersebut pada tahun 2022. Penelitian ini bertujuan untuk mengetahui kemampuan literasi lingkungan siswa sekolah adiwiyata mandiri di tingkat SMA dan untuk melihat implementasi empat komponen program adiwiyata tersebut. Penelitian dilakukan dengan metode campuran menggunakan teknik tes dan non tes. Temuan pada penelitian ini berupa 1) terdapat perbedaan yang signifikan pada kemampuan literasi lingkungan siswa program studi MIPA dan IPS, 2) tidak terdapat perbedaan yang signifikan pada kemampuan literasi lingkungan siswa berdasar jenjang kelas (X, XI, dan XII), 3) terdapat hubungan yang signifikan antar aspek literasi lingkungan. Kemampuan literasi lingkungan siswa secara keseluruhan dalam penelitian ini berada pada kategori sedang dan implementasi empat komponen program adiwiyata di SMA sudah berjalan dengan baik meskipun masih terdapat beberapa hambatan.
Evaluasi Strategi Pengajaran dalam Pembelajaran Biologi di SMA
Authors: Zaliani Indah , Aliza Nanda Nur , Sihotang Selestina Rebacca , Suryanda Ade , Rini Daniar Setyo
Published: April 2024

SMA Negeri 12 Jakarta adalah salah satu sekolah menengah atas negeri yang terletak di Jakarta, Indonesia. Sekolah ini menyediakan pendidikan tingkat menengah atas untuk siswa kelas X hingga XII. SMA Negeri 12 Jakarta juga dikenal sebagai salah satu sekolah yang memiliki standar pendidikan yang tinggi dan prestasi akademik yang baik. Dengan menggunakan pendekatan kualitatif dalam Penelitian ini yang bertujuan untuk menganalisis strategi pengajaran yang digunakan dalam pembelajaran Biologi di SMA Negeri 12 Jakarta. Pada penelitian ini guru biologi di SMA Negeri 12 Jakarta menjadi subjek penelitian yang mana dengan memilih guru yang memiliki pengalaman dan wawasan yang relevan dengan strategi pengajaran biologi. Metode dalam penelitian ini yaitu observasi langsung ke SMA Negeri 12 Jakarta dan melakukan wawancara langsung dengan narasumber yaitu guru biologi di sekolah tersebut. Dalam penelitian ini dapat disimpulkan bahwa Pendekatan luas dalam mengajar biologi di sekolah ini mencakup metode ilmiah, aktivitas interaktif, dan penggunaan teknologi. Guru-guru aktif dalam MGMP dan kegiatan KIR menciptakan lingkungan pembelajaran yang memotivasi siswa. Siswa mengembangkan keterampilan berpikir kritis dan kerja tim melalui media pembelajaran interaktif, proyek tim, dan integrasi disiplin ilmu lainnya. Pembelajaran berkala dan partisipasi dalam kegiatan ekstrakurikuler KIR meningkatkan minat siswa dalam biologi. Merawat tanaman di sekolah juga mengajarkan siswa tentang keberlanjutan dan kesadaran lingkungan. Pendekatan ini berhasil menciptakan lingkungan pembelajaran yang efektif.
ANALISIS PENGGUNAAN GAMES EDUKASI BERBASIS ANDROID DALAM PEMBELAJARAN BIOLOGI SISWA SMA NEGERI 11 PEKANBARU
Authors: Amelia Natasya , Hajar Ibnu
Published: April 2024

Tujuan dari penelitian ini adalah untuk mengetahui bahwa penggunaan games aplikasi berbasis  android dalam pembelajaran biologi siswa SMA Negeri 11 Pekanbaru. Metode penelitian yang digunakan adalah penelitian deskriptif kuantitatif. Jenis data yang di gunakan data kuantitatif seperti angket. Sumber data primer di peroleh dari angket, sedangkan data skunder di peroleh dari jurnal. Penelitian ini di lakukan di SMA Negeri 11 Pekanbaru. Pada penelitian ini yang di amati adalah game berbasis android  dalam pembelajaran biologi di sekolah. Untuk populasi dan sampel yang di gunakan yaitu seluruh siswa kelas X.1 dan X.2 SMA Negeri 11 Pekanbaru dengan menggunakan teknik sampel jenuh dan semua populasi dijadikan sampel. Teknik pengumpulan data yang di gunakan dalam penelitian ini adalah dengan menggunakan teknik kuisioner, dengan instrumen penelitian adalah angket yang di isi oleh siswa melalui google form. Angket yang digunakan untuk memperoleh data tentang pendapat siswa mengenai game berbasis android dalam pembelajaran Biologi di sekolah. Kemudian data akan di analisis secara deskriptif kuantitatif. Hasil penelitian analisis data menunjukkan pada kesimpulan bahwa keinginan penggunaan games edukasi dengan android pada kriteria sangat tinggi (86%), motivasi siswa menggunggunakan games edukasi dengan android pada kategori baik (62%), dampak penggunaan games edukasi dengan android pada kategori baik  (65%). Berdasarkan hasil penelitian dapat disimpulkan penggunaan games edukasi dengan android dalam pembelajaran biologi di kelas X SMA Negeri 11 Pekanbaru tahun ajaran 2023-2024 pada kategori baik.Kata Kunci: Game edukasi, Android, Pembelajaran Biologi
Metabolic stress and stress-limiting mechanisms in bronchial asthma combined with type 2 diabetes mellitus
Authors: Skiba T. A.
Published: April 2024

Objective: to study the indicators of lipid peroxidation and the antioxidant system in the blood and moisture condensate of exhaled air in patients with AD combined with type 2 diabetes, and in the blood of these patients — total metabolites of nitric oxide. Materials and methods: the study involved 215 patients with persistent BA of moderate severity aged (38.6±2.4) years, including 88 men (40.9%), 127 women (59.1%). Among the examined patients with BA there were 64 — group I, persons with BA combined with type 2 diabetes — 151 (group II). The parameters of the lipid peroxidation system (LPS) in the blood serum were studied: malondialdehyde (MDA), diene conjugates (DC), and the antioxidant system (AOS) according to the activity of catalase and superoxide dismutase (SOD), the amount of total metabolites of nitric oxide (NOx), in the condensate of exhaled air moisture (KEAM) was determined general oxidant (GOA) and antioxidant (AOA) activity. Results: in patients with BA combined with type 2 diabetes, an increase in the concentration of POL products in the blood was revealed: MDA was 2.6 times (p<0.05) compared with the control group and 1.3 times (p<0.05) compared with the indicator in patients with AD, DC, respectively, 2.0 times (p<0.05) compared with the control group and 1.2 times (p<0.05) compared with I group. The activity of the enzymes AOS catalase and SOD in patients with comorbidity of BA and type 2 diabetes was found to be lower than in patients of group I. In the KEAM of patients with comorbidity of BA and type 2 diabetes, a significant increase in OOA and a decrease in OAA were noted. The concentration of NOx in the blood serum of group II patients was 1.6 times higher than in the control group (p<0.05), but 1.4 times lower than in patients with AD without comorbidity with type 2 diabetes (p<0.05). The direction of the revealed correlations between the products of POL in blood serum and KEAM confirmed the systemic nature of metabolic changes in the body of patients with AD, and their strength in group II patients — the negative effect of comorbid type 2 diabetes on the greater severity of these metabolic changes. Conclusions: the resulting changes in the state of LPS and AOS in the blood and KEAM of patients with BA combined with type 2 diabetes can be characterized as systemic metabolic stress, both components of which: oxidative and nitrosive are supported by insufficient stress-limiting mechanisms  — low activity of AOS enzymes and possible depletion of nitric oxide production, which should be reflected in the means of correcting metabolic disorders in patients with this comorbidity.
mHealth Intervention for Elevated Blood Pressure Among College Students: Single-Arm Intervention Study
Authors: Tran Dieu-My , Dingley Catherine , Bonilla Roger
Published: April 2024

Background

Current evidence reveals a growing pattern of hypertension among young adults, significantly increasing their risk for cardiovascular disease later in life. Young adults, particularly those of college age, often develop risk factors related to lifestyle choices in diet, exercise, and alcohol consumption. Developing useful interventions that can assist with screening and possible behavioral modifications that are suitable and appealing to college-aged young adults could help with early identification and intervention for hypertension. Recent studies indicate mobile health (mHealth) apps are acceptable and effective for communication and message delivery among this population.

Objective

The purpose of this study was to examine the feasibility of using a mobile smartphone delivery system that provides tailored messages based on participant self-measured blood pressure (BP) with college-aged young adults.

Methods

Using a single-arm intervention, pilot study design, the mHealth to Optimize BP Improvement (MOBILE) intervention was implemented with college students aged 18 years to 39 years who had systolic BP >120 mm Hg and diastolic BP ≥80 mm Hg. Participants were required to measure their BP daily for 28 days, submit the readings to the app, and receive preset educational text messages tailored to their BP value and related to encouraging healthy lifestyle modifications. Changes in a participant’s BP was evaluated using a mixed regression model, and a postintervention survey evaluated their perspectives on the mHealth intervention.

Results

The participants’ (N=9) mean age was 22.64 (SD 4.54) years; 56% (5/9) were overweight, and 11% (1/9) were obese. The average daily participation rate was 86%. Of the 9 participants, 8 completed the survey, and all indicated the intervention was easy to use, found it increased awareness of their individual BP levels, indicated the text messages were helpful, and reported making lifestyle changes based on the study intervention. They also provided suggestions for future implementation of the intervention and program. Overall, no significant changes were noted in BP over the 28 days.

Conclusions

The mHealth-supported MOBILE intervention for BP monitoring and tailored text messaging was feasible to implement, as our study indicated high rates of participation and acceptability. These encouraging findings support further development and testing in a larger sample over a longer time frame and hold the potential for early identification and intervention among college-aged adults, filling a gap in current research.
Application of Functional Equivalence in English-Chinese Subtitle Translation in Green Book
Authors: Hang Qi
Published: April 2024

Under the trend of globalization, movies, as a medium of cultural communication and exchange between countries around the world, are becoming increasingly prominent. Subtitle translation, which has been sublimated from an obstacle between cultures to a convenient tool, can restore the effects of art in movies and television programs, and extend the meaning within the works to facilitate cultural dissemination. In this sense, different meanings within movies as well as cultural background and character features have to be translated. This article intends to summarize the functional equivalence theory, and base the analysis of translation skills and characteristics in the movie Green Book on the theory. Through further consideration for the relationship between the theory and the practice, the research questions of how lexical equivalence, syntactic equivalence, textual equivalence and stylistic equivalence function and cooperate with one another are to be fully investigated. Finally, the conclusion is to be drawn with the purpose to show the original taste of the movie Green Book and put forward some advice in subtitle translation.
Research on How Internet Celebrity Food Goes out of the Circle to Help Local Economic Development Based on the Barbecue Phenomenon in Zibo
Authors: Liu Shunan
Published: April 2024

In recent years, with the rise of the Internet, the Internet celebrity economy has developed vigorously, gradually penetrating into various fields such as social networking, e-commerce, and live broadcasting, and various types of Internet celebrity economic products have emerged in endlessly. Internet celebrity food makes full use of the advantages of new media platforms to promote the development of local economy. Although most of the existing literature believes that Internet celebrity food is the key to boosting urban development, most scholars study Internet celebrity food alone or from the perspective of helping economic development. There are few documents that combine the two to study the emergence of Internet celebrity food. The reasons for the circle and the mechanism to promote local economic development. This article takes Zibo Barbecue as the research object to explore the factors that lead to the prosperity of this Internet celebrity food and its future development model, thereby helping local economic development and providing relevant optimization paths for this purpose.
3D PRINTING TECHNIQUE: A REVIEW ON THE APPLICATIONS IN PHARMACEUTICAL MANUFACTURING
Authors: YADAV ABHISHEK , YADAV MANISH , YADAV ASHISH KUMAR , MISHRA SHWETA , JENA JITENDRA , RAI JITENDRA KUMAR
Published: April 2024

In the realm of pharmaceutical manufacturing, 3D printing technology stands on the brink of a transformable revolution. This article passionately explores the boundless potential of 3D printing in shaping the future of pharmaceuticals, aiming to inspire researchers. It delves into crucial aspects: an overview of 3D printings in drug development, its advantages in drug production, and the pivotal role of personalized medicine. The article also discusses the creation of patient-specific medical devices, novel drug delivery systems, and the anticipated challenges in adopting 3D printing. Real-world case studies showcase successful applications while addressing the regulatory challenges associated with 3D-printed pharmaceuticals. By bridging existing knowledge gaps, this comprehensive article acts as a guiding light for those dedicated to advancing pharmaceutical research. It empowers researchers with profound insights into this disruptive technology, fostering innovation and collaboration within the community. The untapped potential of 3D printing in pharmaceuticals is vast and promising. Together, researchers can pioneer the future of pharmaceutical manufacturing, benefiting patients globally and propelling scientific advancement. Join us in this exhilarating journey of exploration and discovery as we harness the full capabilities of 3D printing for the betterment of healthcare and the progress of science.
EFFECTS OF PLATELET-RICH PLASMA INJECTIONS ON OSTEOARTHRITIC PATIENTS
Authors: PRAKASH D. RAVI , KUMAR C. SIVA , NARAYANA SATYA , DEEPAK
Published: April 2024

Objective: Various treatment options are available for knee osteoarthritis such as medical treatment with NSAID, conservative management with platelet-rich plasma (PRP) and corticosteroids. We have done this prospective study to know the use and safety of platelet- rich plasma (PRP) injections in knee osteoarthritis (KOA) patients. We know platelet rich plasma (PRP) clinical and functional outcome in knee osteoarthritis (KOA) by doing this study and using the available literature.
Methods: This prospective study consisted of a total number of 96 patients suffering from knee osteoarthritis. Both males and females are included. Intra-articular injection of platelet rich plasma (PRP) was given in sterile conditions and clinical and functional outcomes were analyzed with Western Ontario and McMaster University Arthritis Index (WOMAC), Visual Analogic Scale (VAS), and Knee Society score (KSS). This study is done in a tertiary care institute during the study period.Results: Most patients were females aged>40 years with knee osteoarthritis. The injections of platelet rich plasma (PRP) showed results at three, six and twelve months follow-up showed significantly reduced WOMAC scores, Visual Analogic Scale (VAS) and Knee Society score (KSS). No complications were observed during the follow-up period.
Conclusion: The results confirm the efficacy of the PRP injections on Knee osteoarthritis, suggesting that decreasing pain was obtained one month after injection, with the best results observed after 12 months—however, a more extensive study group. Follow-up is required for a prolonged period to assess the efficacy of PRP injection.
ANTIFUNGAL STEWARDSHIP: MITIGATING INAPPROPRIATE PRESCRIPTIONS IN VULVOVAGINAL CANDIDIASIS IN TERTIARY CARE HOSPITAL, CENTRAL INDIA
Authors: VIGNAN NARLAPATI , TIWARI VIKALP , KHARAT AVINA , KUMARI RUCHI
Published: April 2024

This study aims to reduce the inappropriate prescriptions of antifungal medications for vulvovaginitis candidiasis in a tertiary care hospital in central India. An ambispective, observational study was conducted in the Department of Pharmacology of MGM Medical College and Maharaja Yashwantrao Hospital in Indore, MP, over three months (i.e.,12 w from August to October 2023). The study encompassed a retrospective analysis of prescriptions for vaginal candidiasis over a period of five weeks in August-September 2023, followed by a prospective analysis over the subsequent five weeks of September-October 2023post-implementation of interactive training sessions, discussions, and antifungal guidelines for two weeks. From a total of 130 randomly selected prescriptions, 69 prescriptions were perused retrospectively, while 61 prescriptions received prospective analysis. The post-implemented audit showed a marked reduction in antifungal prescriptions with a difference of 12.4%. An increase in the documentation of examination findings was also observed, from 46.7% to 69.7%. This implementation successfully mitigated inappropriate prescriptions of antifungals, with sustained reductions demonstrated over the 3 mo of the study period, emphasizing the effectiveness of educational interventions.
Breaking Barrier: Exploring Psycholinguistics Through Cinematic Analysis
Authors: Prasad Pournamy , Ravikumar N.
Published: April 2024

Many people in this world suffer from various type of learning disorders. Dyslexia is one such condition with which a lot of people struggle. This abstract presents a psycholinguistic analysis of the films, Taare Zameen Par and Mical exploring the portrayal of language development and its psychological implications. Drawing on psycholinguistic theory, this analysis examines how language acquisition, communication disorders, and the socio-emotional aspects of language are depicted in these cinematic narratives. Psycholinguistics theory is a multidisciplinary field that studies the relationship between language and the mind including how people produce comprehend and acquire language. Dyslexia is a condition that often intersects with the field of psycholinguistics and it examines how this condition affects various aspects of language processing, such as phonological awareness, decoding skills, reading fluency and comprehension. Psycholinguistics theory helps to understand the underlying cognitive processes involved in reading and language difficulties experienced by individuals with dyslexia. The movie Taare Zameen Par and Mical portrays different perspectives on dyslexia highlighting the challenges and strength of individuals with the condition and promoting awareness of understanding. Through the analysis of these movies, this abstract underscore the power of cinema as a medium for exploring the intricacies of language and cognition. By examining the portrayal of language development and communication in Taare Zameen Par and Mical through a psycholinguistic lens, this abstract offers insights into the complex interplay between language, cognition, and culture, enriching our understanding of the human experience.
МКП-ФЭУ – ​счетчики фотонов для УФ- и видимой областей спектра
Authors: Кулов С.К. , Алкацева Т.Д. , Федотова Г.В. , Сенцова Е.И.
Published: April 2024

Сообщается о разработке МКП-ФЭУ – счетчиков фотонов в ультрафиолетовой и видимой областях спектра для оптико-физических измерений. Рассматриваются особенности конструкции и технологии разработанных ФЭУ с МКП, позволяющие достичь высокого отношения пик/долина, низкого уровня скорости счета темновых импульсов, повышенного уровня долговечности. Приводятся различные варианты конструктивного исполнения ФЭУ (в виде вакуумных блоков и со встроенным в единый корпус с вакуумным блоком делителем напряжения).
О достижимости целей действующей Концепции технологического развития. Часть II
Authors: Кошкарева О.А.
Published: April 2024

Во второй части краткого обзора Концепции технологического развития Российской Федерации до 2030 года продолжено рассмотрение структуры, принципов и целей, описанных в Концепции. Даны определения деградирующих и отрицательных
инноваций. Сделаны выводы о сильных и слабых сторонах Концепции (отход от стандартных статистических показателей и использование непродуманных точек отсчета) и предложены решения, направленные на корректирование последствий слабых сторон.
Predictive Modeling for Cardiovascular Disease Risk Assessment
Authors: Muthuvel Dr. P.
Published: April 2024

Abstract: Heart disease remains one of the leading causes of mortality worldwide. Early detection and risk assessment are crucial for effective prevention and management. This research paper presents a novel approach utilizing machine learning techniques, particularly decision trees, for predicting heart disease risk. The study utilizes a dataset sourced from the UCI Machine Learning Repository, encompassing diverse features such as age, gender, height, weight, cholesterol levels, and other relevant attributes. The proposed model aims to accurately classify individuals into risk categories based on their demographic and health-related information. Additionally, a user-friendly web application is developed using Python Flask, enabling users to input their data and receive instant risk assessments. Through rigorous experimentation and evaluation, the efficacy and reliability of the predictive model are demonstrated, offering valuable insights for early intervention and personalized healthcare strategies in the fight against heart disease.
Social Net Secure using Natural Language Processing and Machine Learning
Authors: Kamala Ms .M.
Published: April 2024

Abstract: In our contemporary era, social networking platforms have seamlessly integrated into the daily lives of the majority of individuals. With each passing day, a multitude of users create profiles on these platforms, fostering connections with others irrespective of geographical barriers or time constraints. While these platforms offer invaluable benefits to users, they also present inherent security challenges, particularly concerning the safeguarding of users' personal data. Addressing the risks associated with social networking platforms necessitates a systematic analysis of user profiles to discern potential threats. Through classification, we aim to distinguish between authentic and fraudulent profiles within these networks. Although various classification methods exist for detecting fake profiles, achieving optimal precision rates remains a formidable task. To enhance the precision rate of fake profile detection within social systems, this paper proposes the utilization of advanced Machine Learning (ML) and Natural Language Processing (NLP) techniques. Leveraging algorithms such as Support Vector Machine (SVM) and Naïve Bayes, we endeavor to refine the accuracy of identifying fraudulent profiles.
Use of Machine Learning to Identify Fake Profiles
Authors: Kumar Dr. G. Ravi
Published: April 2024

Abstract: These days, social media plays a big role in our everyday lives. Presently, over 50% of the global population actively utilizes social media sites. The prevalence of fraudulent accounts on social platforms is a serious problem that has been brought about by their ever-growing popularity. The goal of these fictitious accounts is to mimic or deceive other people. They are now a simple means of deceiving consumers into purchasing phony goods and services. Additionally, billions of people's personal information is in jeopardy. It is now crucial to identify and disable the phony accounts before any damage is done because of these dangers. Thanks to machine learning, it's now simple to identify millions of these accounts automatically. Users fabricate profiles to disseminate false information, including hate speech, rumors, texts from bullied individuals, and more. Researchers used deep learning and machine learning models to propose some strategies to mitigate this problem, yet a large number of phony accounts remain. These phony accounts are unacceptable for a respectable social networking site, nevertheless. This article provides an overview of the latest developments in social networking fake account identification
Students Attention Monitoring in Learning Environment
Authors: Vundrakunta Venkatavinaykumar
Published: April 2024

Abstract: Educational facts mining is a discipline that specializes in developing techniques to take a look at the specific and large-scale information produced by using educational environments and applying those methods to better recognize the scholars and environments in which they study. Predicting pupil execution is one of the greatest essential issues in scholarly realities mining and is gaining recognition. Student performance prediction attempts to are expecting a student's grades before they join in a course or complete an exam
Medicinal Properties of Phoenix Dactylifera L: A Review
Authors: Thacker Hency
Published: April 2024

Abstract: Phoenix Dactylifera L. also known as date palm is monocotyledonous plant belonging to arecaceae family. Date palm is dioeceous, which means it has separate male and female saplings. In the present study, phytochemical composition and therapeutic properties of date palm fruits, seed and different other parts are discussed. Phoenix Dactylifera L. is cultivated in different parts of world major among which North Africa, Arabian Peninsula , Middle east including Iran, Iraq, USA, Pakistan, Saudi Arabia, Egypt, UAE, Sudan, South Sudan, Algeria, Tunisia, India, Spain, Maurutiana, Morocco, Mali, Oman, Tanzania, Australia and Libya Date palm fruits possess numerous medicinal properties like antioxidant, antimutagenic, immunomodulatory, anti-hyperlipidemic, gasoprotective, hepatoprotective, anti-cancer, anti-mutagenic, nephroprotective, antimicrobial and anti-inflammatory properties. Phoenix Dactylifera L. is enriched with alkaloids, fatty acids, amino acids flavanoids, anthraquinones, saponins, terpenoids and tannins. In addition to this, it possess considerable amount of essential mineral elements such as potassium, calcium, magnesium, phosphorous, iron and zinc.
Dermatological Categorization Using Deep Learning
Authors: Kawdi Sangmeshwar
Published: April 2024

Abstract: Skin disease is a rampant medical condition in today's society that demands immediate attention. The manifestation of small circular or irregularly shaped spots on the skin is a clear indication of skin disease. If left untreated, skin disease could progress into skin cancer, a condition that poses a great danger to the patient's life. This project is set to detect possible signs of skin abrasions or infections. By utilizing neural networks or machine learning algorithms to scour an open-source dataset of skin diseases, the project provides the most accurate match to the patient's likely condition. We will use CNN transfer learning techniques, particularly VGG19 or different Resnet approaches, to ensure maximum accuracy. Our goal is to cover at least 12+ out of the 23 available classes and achieve an accuracy rate of 90% or higher on the training set and 85% or higher on the validation set. The project will also include the best available treatments to treat any detected disease with a tailored dataset. We are committed to providing top-notch medical care and ensuring the best possible outcome for our patients.
The Synergy of Events and Technology: MERN Stack Solutions for Seamless Event Rentals
Authors: Singh Om Prakash
Published: April 2024

Abstract: The combination of technology with events in the modern day has drastically changed the way that event management is done. This paper explores how the technologies of Express.js, React.js, Node.js, and MongoDB (MERN stack) are integrated into event rental solutions, and how this allows for smooth and effective event planning and execution. Through a comprehensive analysis of several aspects, including development processes, user experience design, scalability, and integration options, this study clarifies the benefits and drawbacks of utilizing the MERN stack for event rental platforms.