bluuebunny/crossref_metadata_2025 huggingface dataset:
Specificity of tourist activities of sea cruises and localization of their economic activity
Authors:   Odessa National Maritime University, SEMENOV Vasil , ALTUKHOVA Valeriia ,   Odessa National Maritime University
Published: September 2022

Abstract. Modern cruise tourism is becoming the most promising type of tourism due to the independence of the season and customer orientation with a high level of income. Therefore, as the economic environment develops, the need to develop cruise tourism in the world becomes an important task for the state and in particular for all enterprises, which thanks to it gain an advantage in the competition for the customer. A cruise is not only the organization of sea and river voyages with visits to port cities of several countries, but also within one. Cruise tourism is characterized by a skillful combination of diverse consumer needs, which is very important in a competitive market. Methods. The aim of the article is to substantiate the theoretical, methodological and practical aspects of cruise tourism, study its state, reveal its role in ensuring sustainable development and provide practical recommendations for further growth of the potential of the cruise industry. Results. The achievement of this goal was achieved by solving the following tasks: identified the nature, prerequisites and factors of cruise tourism and the global cruise industry; outlined and highlighted the specifics, competitive advantages of tourism cruises, their place in the overall turnover of the tourism business. Trends in the development of cruise tourism and the localization of economic activity of sea cruises are studied and the priorities and potential opportunities for the development of cruise tourism in Ukraine are also assessed. Scientific novelty. An important component of cruise tourism is the regulation of the state and international cruise tourism organizations. The state has a direct influence on the development of cruise tourism. Practical significance. The objects of state regulation in the field of maritime tourism are the waters of the sea and coastal areas, in relation to coastal areas, the object of state regulation is the tourist infrastructure within the coastal areas. Given the specifics of tourism and the localization of economic activity of sea cruises and the fact that this sector of the economy covers almost all sectors of the economy and stimulates their development, it is important to determine the competitive advantages that shape the country's potential in the cruise industry. The article highlighted the most important factors of economic growth of both industries and enterprises involved in the cruise industry and the country as a whole, and identified competitive advantages in the cruise business of Ukraine. Key words: recreation; tourism; cruise, cruise tourism, cruise industry, cruise countries, sustainable development of cruise tourism, localization of economic activity of sea cruises competitive advantages.
Legal regulation of the participation of citizens in the defense of Ukraine during a military conflict
Authors:   NAU Flight Academy, TROYANSKY Oleksandr
Published: September 2022

Abstract. The article analyzes the main legal acts that regulate the participation of citizens in the defense of Ukraine during the military conflict. The main problems are highlighted faced by territorial societies in organizing resistance forces in their territories at the beginning of the war. The main components of territorial defense, including military, civil and military-civilian were analyzed. It was considered the features of the creation of volunteer formations of territorial communities and the order in which they are assembled. It was determined the grounds, procedure and main forms of participation of citizens in fighting back and deterring the armed aggression of the Russian Federation and the states against Ukraine. Key words: military conflict, military volunteer activity, volunteer formation, armed aggression, armed conflict, territorial defense.
Actualities of the activity of the judiciary in Ukraine in war-time conditions
Authors:   West Ukrainian National University, BRATASYUK Oksana , GERCHAKIVSKA Olha ,   West Ukrainian National University
Published: September 2022

Abstract. The presented study describes the features of the administration of justice in wartime, war or postwar period. Emphasis is placed on the characteristics of historical approaches to the functioning of the judiciary in Ukraine and the world, the systematization of judicial institutions during the war and postwar periods. The normative and legal support of justice in Ukraine after the beginning of the Russian-Ukrainian war is analyzed. Applied features of the functioning of the judicial system of Ukraine in martial law are outlined. Key words: judiciary, martial law, tribunal, war, war crimes, judiciary, human rights.
Israeli experience of post-war reconstruction of the economy
Authors:   Kherson State Agrarian and Economic University, TANKLEVSKA Nataliya , KARNAUSHENKO Alla ,   Kherson State Agrarian and Economic University, PETRENKO Victoriya ,   Kherson State University
Published: September 2022

Objective. The main objective of this article was to study the Israeli experience of post-war economic reconstruction and to define the factors effecting the growth and development of the economy of Israel. Methods. We used such general and specific methods as comparison, analysis, synthesis, graphic method and grouping in order to gain this objective. Results. As a result of this research we defined the main indicators of economic development of Israel and its position in world ratings. We also defined the main indicators of development of Israel as a state, among which are international support, issue of government bonds, reparation from Germany, and development of the New Economic policy, establishment of the Israeli Military Force culture and inflow of human resources. Launching of major infrastructure projects played a significant role in economic recovery, such as water supply system construction, sea ports and processing plants. Moreover, state supported agriculture and light industry. The economy of Israel is highly developed due to support to research and development achievements made by scientists, thus, it is based on gaining new knowledge and its practical implementation. The basis for Israel’s economic miracle is science, the development and implementation of new technologies with their further adaption for real manufacturing. Israel’s experience is a valuable example of post-war reconstruction of a country and the way to bring the country out of ruins. It is worth taking Israeli experience into account while developing Ukraine’s Marshall Plan when it goes about taxation, state production support, human capital accumulation, development of innovations and their implementation into processing industry. Scientific novelty. In the research the authors proved that the phenomenon of Israel’s economic miracle is unique and its experience is a positive example of how to make the economy innovative out of nothing. Practical significance. The research defined the factors effecting the establishment of the economy of Israel. These factors may be used in the Ukrainian reality, while developing the recovery plan. Key words: economy competitiveness, innovative economy, technology and innovation, post-war reconstruction, international experience, global economy, development.
Strategic priorities of the national innovation system of Ukraine in favorable innovation environmental for economy
Authors:   Classic Private University, TOMAREVA-PATLAKHOVA Victoria , KOKORINA Victoria ,   Classic Private University
Published: September 2022

The article systematizes measures to increase the international innovation capacity of Ukraine's economy within globalization. The strategic directions to ensure favorable innovative environment of Ukraine's economy within globalization are defined. The principles for developing innovative activity within the national innovation system of Ukraine are systematized. The study substantiates priority directions of the strategic innovation policy of Ukraine. Key words: innovation capacity, innovation environment, national innovation system, strategic priorities, innovation model, innovation policy, strategy of national innovation system development.
Modelling of accounting support for budgeting fund administrators’ activity
Authors:   Kyiv National Economic University named after Vadym Hetman, LARIKOVA Tatiana
Published: September 2022

As a result of the research the contents of modelling was defined as a settlement of logical and economic links of the elements of an accounting process required for the effective management system. The requirements to organization models of accounting support were clarified as: completeness, consistency, consideration of common principles. In particular, the principles and functions of modelling of accounting support for budgeting funds administrators’ activity were defined. The concept of accounting support for budgeting fund administrators was clarified as a system of connections, interdependence of the objective, principles, methods and means of provision of administrative information about the budgeting funds administrators’ activity with adequate, accurate and full information about availability, movement and use of assets, capital and liabilities at all stages of turnover within the constant reform of regulatory support aimed at minimizing risks and effective use of budgeting funds. We developed a system model of accounting support for budgeting funds administrators, which combines management stages and reflects organic ties of accounting and budget funds administration by economic entities. Key words: accounting support, management, budgeting funds administrators, assets, capital, liabilities, information base, strategy.
Organization of strategic accounting in the practice of modern aviation enterprises
Authors:   Flight Academy of National aviation University, OSTAPENKO Oksana
Published: September 2022

Abstract. The article is devoted to topical issues of implementation of strategic management accounting in the practice of modern airlines. The content of strategic accounting, its importance and effectiveness in the management of aviation enterprises, its individual functions are considered. It is emphasized that strategic management is one of the necessary conditions for determining the future direction of development of the aviation industry. To overcome this problem, a system of information support for strategic management of airlines in the air transport market is proposed, which will take into account the internal and external information sphere, reflect the comprehensive consolidation of information about the company and strategic prospects. The advantages of introduction of strategic management accounting in the practice of modern aviation enterprises are revealed. Key words: management accounting, strategic management accounting; aviation enterprise; air transportation market; accounting system; management; accounting system.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF UNTUK MENINGKATKAN KEMAMPUAN BAHASA DAN KOGNITIF PADA ANAK USIA DINI ( Studi Pada Kelompok A Kelurahan Talang Ulu )
Authors: Harliza Titik , Kurniah Nina
Published: September 2022

This study aims to develop interactive media to improve language and cognitive skills in early childhood. The research method used was the Borg and Gall Research and Development (R&D) method with 10 development steps. Based on the results obtained, it can be concluded: (1) Based on the validation of media experts and material experts, this interactive media falls into the "very feasible" category to be used to improve language and cognitive skills. (2) The use of interactive media can improve early childhood language skills, in terms of listening and speaking. The results of small group trials are included in the "good" category and the results of large group trials are included in the "very good" category. (3) The use of interactive learning media can improve early childhood cognitive abilities. The results of the small group trial were in the "very good" category. In the large group trial, it was included in the "very good" category
PENGEMBANGAN E-MODUL MATA PELAJARAN MATEMATIKA UNTUK MENINGKATKAN PRESTASI BELAJAR SISWA KELAS VIII DI SMP NEGERI 9 PAGAR ALAM (Studi Pengembangan Pada Mata Pelajaran Matematika Siswa Kelas VIII Di SMP Negeri 9 Pagar Alam)
Authors: Firmansyah Firmansyah
Published: September 2022

The aim of this study was to produce learning media in the form of interactive e-modules to improve students' learning achievement in mathematics class VIII at SMP Negeri 9 Kota Pagar Alam. In this study, a development design (Development Research) was used. The research subjects were Grade VIII students of SMP Negeri 9 Pagar Alam. The data collection techniques used in the study were assessment sheets and student test results. The data analysis used mean and t-test. The material and media expert validation instrument in the study was a Likert scale. The conclusion of this research is that the mathematics E-module developed interactively, is of high quality and feasible as a learning medium at SMP Negeri 9 Kota Pagar Alam class VIII in terms of media components, material, and learning process as well as in terms of appearance, text, images, videos, and operation. The development of e-mathematics modules is effective in improving student learning achievement based on the results of limited-scale and wide-scale trials, there are significant differences
PENERAPAN MODEL PEMBELAJARAN PETA PIKIRAN UNTUK MENINGKATKAN BERPIKIR KRITIS DAN KETERAMPILAN MENULIS KARANGAN NARASI
Authors: Nurhayati Nurhayati
Published: September 2022

This study aims to describe the application of the mind map learning model in improving students' critical thinking, improving the writing skills of narrative essays in Indonesian students of grade VII SMPN 3 Kikim Timur, describing how the effectiveness of the application of the mind map learning model in improving the writing skills of narrative essays in the eyes. Indonesian language lessons. The research design used was classroom action research (PTK) and quasi-experimental. The research subjects were students of class VII.A for the PTK class, class VII.B students for the experimental class and class VII.C students for the control class even semester of the 2020/2021 school year. The research instrument used observation sheets and tests. The research data were analyzed using descriptive statistics, mean, percentage, and t-test. The results of the study concluded that the mind map learning model could improve students' critical thinking and narrative essay writing skills in Indonesian class VII SMPN 3 Kikim Timur subjects
Perancangan Sistem Penunjang Keputusan Penerimaan Beasiswa Dengan Metode WASPAS Berbasis Website
Authors: Bagus Sajiwo Herlambang Nurwachid
Published: September 2022

Semakin mahalnya biaya pendidikan dari tahun ke tahun tentu menjadi sebuah masalah yang harus kita hadapi. Untungnya sudah banyak program beasiswa yang menjadi andalan untuk menghadapi masalah itu. Demikian halnya Universitas Narotama yang memiliki program pemberian beasiswa terhadap mahasiswa. Dalam hal ini Universitas Narotama dalam proses penyeleksian salah satu beasiswa, yaitu pemotongan ukt masih menggunakan metode manual. Dimana seleksi manual dirasa kurang efektif karena target yang dimaksudkan bisa kurang sesuai. Maka dari itu terciptalah penelitian ini yang bertujuan untuk membuat sebuah aplikasi sistem penunjang keputusan dengan menggunakan metode Weight Aggregated Sum Product Assesment (WASPAS) dalam penerimaan beasiswa berbasis website. Metode WASPAS dianggap sesuai dengan seleksi penerimaan beasiswa karena metode WASPAS bekerja dengan cara melakukan proses perangkingan berdasarkan atribut dengan bobot yang berbeda-beda [1], sehingga hasilnya lebih optimal.
Perancangan Smart Controlling And Monitoring Tingkat Kekeruhan Air Kolam Dan Pemberian Pakan Ikan Berbasis Internet Of Things (IoT)
Authors: Tan Yamato
Published: September 2022

Proses pengoperasian komponen-komponen penggerak, sensor-sensor, dan switch/kontak yang dapat dikontrol secara wireless melalui jaringan internet (Internet of Things). Prinsip kerja berdasarkan dengan memanfaatkan sensor kekeruhan air dan pH air untuk membaca kondisi kualitas air, lalu memicu solenoid valve dan pompa air untuk membuang air hingga jarak 35 cm antara permukaan air ke sensor ultrasonik apabila kekeruhan >400 NTU atau pH level <7 pH, dan akan berhenti membuang air apabila kekeruhan <400 NTU atau pH level ≥7 pH. Pada proses pengisian air akan segera aktif apabila ketinggian permukaan air kolam >30 cm yang dilakukan oleh sensor ultrasonik sebagai pengukur jarak air, dan akan berhenti mengisi apabila jarak air <30 cm. Dan untuk pemberian pakan ikan yaitu dengan memanfaatkan motor servo sebagai komponen penggerak tutup kaleng pakan dan wadah pakan, dan sensor berat sebagai penimbang berat pakan yang telah jatuh ke wadah pakan.
Organizational Culture as The Basis of Teacher Performance Development
Authors: Santosa Achadi Budi
Published: September 2022

This study not only measures the relationship between organizational culture and teacher performance but also finds an essential foundation for madrasah in building organizational culture and how to improve their performance. A descriptive quantitative approach is used in this research; data collection is done through surveys and the preparation of research instruments. The results show that, in general, the organizational culture is quite good, the values, teamwork, and work performance are also good, while in performance, teachers generally have various levels of achievement, satisfaction, responsibility, honesty, empathy, and persistence in work. In madrasah, organizational culture is related to teacher performance so a superior organizational culture will affect teachers' performance; on the other hand, educational institutions that cannot build a good culture result in decreased teacher performance.
Education Management: Implications of Information Technology Development on The Moral Formation of Adolescents
Authors: Suban Alwan , Ilham Ilham
Published: September 2022

This study aims to determine the implications of Islamic education management in developing information technology for forming adolescent morals. This research is a descriptive type of field research using qualitative methods. The results of this study indicate the various impacts of technological sophistication on the moral behavior of students today so that attention and supervision from various parties are needed so that the following development process does not cause bad things. Supervision from parents, and the surrounding community, holding positive activities involving teenagers, as well as attention and supervision from parents towards students must be more significant and closer to them so that they are more open and easy to direct So that one of the efforts that the education management must take is to combine information technology with human resources. In addition to socializing on how to use technology media, they must provide socialization about the limitations that must be applied by each student so that they are not excessive in using technology media and do not take advantage of information that can damage morale.
Humanistic based Inclusive Education Management in Madrasah: Policy Review
Authors: Mu'is Abdul , Baharun Hasan , Suwandi Suwandi
Published: September 2022

This study aims to analyze inclusive education management policies in madrasah by applying humanistic-based learning at Madrasah Ibtidaiyah Nurus Salam. This research uses a qualitative approach. In order to get an overview of the humanistic-based inclusive education policy, the researchers conducted direct observations, interviews, and documentation. The data analysis technique is carried out circularly, from data collection, reduction, display, and conclusions. The results showed that; First, Madrasah Ibtidaiyah Nurus Salam uses inclusive education policies to accommodate students with special needs by applying humanistic-based learning. Both presentations were conducted using learning analysis, inclusive education design, implementation, and program evaluation. This study has implications for the importance of humanistic-based inclusive education in providing shelter for children with special needs so that they can develop their knowledge through existing school policies.
The Influence of Educators' Perceptions of Principal Leadership and School Culture on Digital Teacher Literacy Services at School
Authors: Sogalrey Febi Adriana Mutiara , Madhakomala R , Santosa Heru , Jamil Asyraf Isyraqi Bin
Published: September 2022

This study was conducted to determine the effect of digital literacy services on educators' perception regarding the leadership of school principals and the influence of digital literacy services on school culture and the influence of school culture on educators' perceptions of principal leadership. Researchers chose a quantitative method with a path analysis technique, and with a total population of 152 teachers and up to 110 respondents. Data were collected through questionnaires distributed to each respondent and analyzed using SPSS 25. The results show a direct influence of teachers' perceptions of school leadership on digital teacher literacy services with a correlation of 0.518 and a path coefficient of 0.306, contributing to 15.84 percent. There is also a direct influence of school culture on digital teacher literacy services with a correlation of 0.586 and a path coefficient of 0.439, contributing to 25.75 percent. Meanwhile, an influence of educators' perceptions regarding principal's leadership and school culture on digital teacher literacy can be viewed from a correlation of 0.483. In other words, there is a joint influence of educators' perceptions of principals' leadership and school culture on digital teacher literacy services with a correlation of 0.64 and a contribution of 41.59 percent. This means that teachers' perceptions of principal leadership and school culture have a significant influence of 41.59 percent on teacher digital literacy services.
Discovering the Child’s Voice in Intergenerational Comics
Authors: Smith Philip
Published: September 2022

This article is an answer to Victoria Ford Smith’s invitation that scholars ‘find ways to talk about real children, despite a critical tradition that insists we conceive of the child as other, alien, or inescapably tied to adult desire’ (256). It concerns the web and print comics series Axe Cop (2009–2017), created by two brothers, Malachai and Ethan Nicolle, and the first volume of Riad Sattouf and ‘Esther’s’ comic book series Les Cahiers d’Esther ( Esther’s Notebooks) (2016).1Each comic followed a similar process: a child related a story, either autobiographical in the case of Esther’s Notebooks or the result of practice play in the case of Axe Cop, to an adult artist who then rendered that story in comic book form. Both texts manifest a, to borrow Rick Iadonisi’s term, ‘narrative wrestling match’ (52); the adult collaborators construct the child as a figure of adult desire while, at the same time, the child author remains a palpable presence in the text and engages in a reciprocal construction of adulthood. In the case of Esther’s Notebooks, Sattouf further uses his collaborator’s lack of knowledge to critique adult assumptions of children, suggesting a more equitable partnership between children and adults.
The Prudential Group Archive: Alexander Korda, London Film Productions and Denham Studios
Authors: Street Sarah
Published: September 2022

This article examines the Prudential Group Archive, a valuable resource for the study of London Film Productions (LFP), the British film company founded by Alexander Korda in 1932. The Prudential, a long-established British life insurance and financial services company, invested in LFP at a time when the British film industry was expanding, and Denham Studios was built as a major production facility in 1936. The primary sources generated through this connection provide a rare opportunity to study the financial operation of a major film company as well as to evaluate the strategies that were put in place by the Prudential to monitor its progress throughout its time as an investor which ended in 1945. The article uses the archive to gain insights into the Prudential’s motives for backing the film industry, the building of Denham, the management of Korda and LFP and the impact of the Second World War. It is demonstrated how the archives provide a unique resource for understanding the pressures on film production in the 1930s, as well as highlighting rarely glimpsed material, infrastructural and collaborative aspects of film history such as the practical operation of studios during the Second World War when they were affected by bomb damage, requisitioning and labour shortages. Unlike archives relating to the British film industry which predominantly deal with film personalities and film titles, the Prudential Group Archive documents the crucial importance of the financial aspects of film production. The article also points to documentation in other collections that can productively be interrelated with the Prudential’s archives.
Repurposing the Archive: Unmade Films,Vampirellaand Adaptation
Authors: Foster Kieran
Published: September 2022

The Hammer Script Archive is held at De Montfort University in Leicester and was opened to researchers in 2012. Primary materials held in the Archive include screenplays, treatments, financial documentation, correspondence, posters, production stills and press books. This article will utilise specifically the material held in the Archive that relates to Hammer’s unmade films. The archive currently holds files on exactly 100 unmade television and film projects, with 185 separate pieces of ephemera directly related to these unmade works.

This article examines how archival materials on unmade or unreleased films not only provide valuable evidence for revisionist film histories but can also be repurposed as events and media that imaginatively reconstitute unrealised projects. While archives are valued by film historians for the contextual evidence that they provide, and are often the only sources of information about films that are lost, when it comes to films that never were, they hold potential beyond the circumstantial.

Unmade films have also been used to frustrate and complicate existing methodologies. But here, papers on unmade films in the Hammer Script Archive provide the point of departure for an examination of the unproduced project Vampirella, which was developed in the mid-1970s, and its subsequent adaptation as a script read live in 2019. As such, documentation in the Archive will be used to provide the production contexts for the original unmade film from which the script was adapted, and then studied to see how these primary materials were repurposed in the subsequent publicly read script. By examining this public event and two other live readings of scripts adapted from unmade Hammer projects, this article will explore the appeal and cultural function of this phenomenon. In doing so it will pose questions about the scripts’ status as adaptations (part-augmentations, part-simulacra?) and fan response (nostalgia for that which never was). What can the film historian recover from such creative plundering of the archive that might be useful methodologically?
RESEARCH OF APPROACHES TO ENVIRONMENTAL IMPACT ASSESSMENT DURING THE IMPLEMENTATION OF THE ROAD CAPITAL REPAIR PROJECT
Authors:   National Transport University, Bubela Andriy , Zagornyak Oleg ,   National Transport University, Sokolova Natalia
Published: September 2022

It is known that all production resources are limited and rare. This economic problem is especially acute for such major components of natural resources as land, forest resources, mineral deposits, water resources, wildlife, which people use in the production of various goods and without which economic activity is impossible. The planning, construction and operation of roads should be carried out in accordance with environmental standards, and the standards themselves should minimize the impact of road networks on the environment. The high level of concentration of heavy industry, unreasonable scale of land reclamation, environmental voluntarism in the development and location of productive forces and the financing of environmental measures on a residual basis lead to an ecological crisis. The effects of economic activity have led to the pollution of vital resources and the degradation of the environment. This article identifies the nature and extent of the main types of environmental impacts during the overhaul of the facility and its subsequent operation. Measures to prevent negative impact on the environment, such as: rational use of land and natural resources, protection of atmospheric air. Ways and means of normalization of the state of the environment, the main source of which on the highway are directly vehicles and road vehicles are considered. The amount of harmful emissions and the distance of their spread varies depending on the intensity and composition of traffic, road, natural and climatic conditions. In the process of existing potential types of environmental impacts is the impact on ambient air. On the geological environment, microclimate, aquatic environment, soil, flora and fauna. The impact on the environment of the road section after major repairs is permanent and is not harmful provided they are harmoniously combined with nature.
ROAD MANAGEMENT FORECASTING MODELS
Authors:   Tavriya National University named after VI Vernadsky, Kiselyov Volodymyr , Kosharnyi Oleksandr ,   National Transport University, Lanovyi Oleksandr ,   National Transport University
Published: September 2022

The network of public roads should ensure the movement of people and the exchange of goods and services by providing uniform land access to different places, in addition to ensuring continuous, safe and convenient connections with appropriate socio-economic efficiency. Highways are a public product, important in providing a service to society that brings significant benefits. The road network is the so-called transport infrastructure. The infrastructure in the economic system is a set of elements that ensure the smooth operation of the relationships of the elements of the system. Thus, the infrastructure, as a subsystem, is designed to ensure the functioning of the relationships between the elements of the system. This is its main function, which is obviously passive. In addition to the function it provides, the infrastructure also has a regulatory function, streamlining the interaction of elements of the system itself. This feature is active. Economic evaluation of the benefits of meeting the objective needs of society is a key category of market economy orientation towards effective development. The social component is a quantitative measure of needs and measures aimed at improving efficiency. Thus, the social sphere becomes on a par with the economic one. This can overcome the unjustified division of efficiency into economic and social, their opposition, which in fact has a narrow financial significance. In a socially inefficient system, an effective economic policy is impossible. Analysis of the functioning of the road network allowed to present it as part of the socio-economic system of reproduction of macro indicators of the functioning of the economic system of the country; this allows us to develop a basis for creating an effective system for forecasting and managing the operation and development of the road network. The synthesis of road forecasting models confirms the hypothesis of methodological compliance of road network operation models both at the micro and macro levels, which makes it possible to build a time-appropriate management system. The article considers the models of forecasting the work of the road sector. efficiency of functioning of the road network; it is proved that there is a unity and interdependence of material and value (price, cost) aspects of the development of the road network. The obtained models demonstrate the principle of socio-economic efficiency - the balances of material and value (value, price) flows are taken into account in the functioning of the road network.
GEODESIC MONITORING AND MATHEMATICAL PROCESSING OF DATA OF DEFORMATIONS BUILDINGS AND STRUCTURES
Authors:   National Transport University, Dovhopoliuk Liudmyla , Omelchuk Sibilla ,   National Transport University, Soloviov Ihor ,   National Transport University, Soloviova Nataliia ,   National Transport University
Published: September 2022

The main causes of deformations are investigated in the article. Observations of deformations of structures are a set of measuring and descriptive measures to identify the magnitude of deformations and the causes of their occurrence. For complex and responsible structures, observations begin simultaneously with the design. At the site of future construction, the influence of natural factors is studied and in the same period a system of reference signs is created in order to determine in advance the degree of their stability. Observations directly on the structure begin from the beginning of its construction and continue throughout the construction period. For most large structures, observations are made during their operation. A measuring network is used for observations, which consists of the following geodetic signs: benchmark - a geodetic sign that fixes a point of the leveling network (the height position of this sign is practically unchanged during observations of deformations of structures); mark - a rigidly fixed on the structure of the building sign, which changes its height and planned position due to deformation of the structure; reference sign - a practically motionless sign in the horizontal plane, relative to which the displacements and rolls of structures are determined. All geodetic signs installed on the building and around it create a survey and support network, which are interconnected by geodetic measurements. The service life of a construction site depends not only on the quality of construction materials and the quality of construction work, but also on the quality of operation, timely and accurate consideration of damage to buildings and forecasting their technical condition, which is impossible without measuring operations to obtain data for its safe functioning. At the stage of operation, the structures are subjected to numerous natural, man-made actions that must be taken into account in the project when choosing materials, developing structures and components, etc. However, in practice, the characteristics of building materials and structures may not meet the requirements of the design documentation, as a result, the combined effect of many factors will lead to accelerated wear of the building. According to the special features of deformation are divided into types: those that change their vertical position and planned displacements, all together spatial displacements. Methods of research of deformations which are chosen according to a kind of deformation are considered.
IMPROVEMENT OF GEODESIC METHODS FOR ROUGHNESS ASSESSMENT OF THE BASE AND PAVEMENT STRUCTURE
Authors:   National Transport University, Ihnatov Serhii , Neizvestna Nataliia ,   National Transport University, Pavliuk Dmytro ,   National Transport University, Sevriuk Borys ,   Group of companies "Dobrograd", Shuliak Ivan ,   National Transport University
Published: September 2022

The article is about the results of the research and development work of highways and airfields laboratory of the National Transport University, namely the development of an experimental sample of a microleveler for evaluating the unroughness of the base and road surface on the basis of an already existing device for measuring the rutting (transverse roughness) of the road surface. The general appearance, main technical characteristics and the algorithm for working with the device are given. The performance of the device was tested by conducting control measurements in parallel with a level of a traditional design on the surface of an asphalt concrete pavement under natural conditions. On the territory of the National Transport University, a series of experimental studies was carried out using known measures of length, accepted as reference ones. Further research and implementation of the device described in the article into the practice of the road industry in Ukraine will make it possible to quickly monitor the construction and repair of road surfaces and coatings and to make corrections in technological processes, to purposefully manage quality, to assess the condition of road surfaces and coatings that are in operation, and to identify local sections of roads with unsatisfactory levelness, which in turn will contribute to the reduction of road accidents associated with unsatisfactory road conditions. At the same time, it is expected that the cost of a domestic microleveler for evaluating the unroughness of the base and covering of road clothing may be several dozen times lower, compared to foreign analogues, under the condition of mass production.
ABOUT OF FORECASTING POSSIBILITY OF HYDROLOGICAL TIME SERIES
Authors:   Ukrainian Hydrometeorological Institute, Artemenko Vladislav , Petrovych Volodymyr ,   National Transport University
Published: September 2022

It is offered forecast the natural time series (hydrological time series) by methods the deterministic chaotic dynamic. At analysis of the time series reveal the hidden regularities at raw data’s. Hereinafter revealled regularities use for realization of the forecast of input data. Hydrological time series either as chaotical time series possible forecast only at determined number step onward. For hydrological time series exists the limit of forecasting (forecasting horizon). The identical prediction possible unless come behind of the forecasting horizon. The aim of the work there is design of the procedure the investigations of the natural time series on possibility of the forecasting. As raw data’s were used the mean day data of consuption for the large flat river of the Ukraine (length is 4*365 points). For forecasting of the natural time series it was used designed an autors modification of the method of Local Approximation. The forecasting horizon of time series was defined by means of factor the linear correlation (on how much points onward (maximum) possible forecast the time series for conservation of the factor the correlation within the range of 0.7 … 1.0). The explored dependency of the forecasting horizon from parameter DIM (Dimensionality Reconstrusted the phase space). The results of the research say for essential determinism of time series (hydrological) – the time series is forecasted on 15 … 22 points onward. Software was designed for investigations of the natural time series (hydrological and hydrochemistry) for forecasting (to find forecasting horizon). The called on investigation has shown that the method of Local Approximation more efficient than classical methods the forecast (for classical methods the adequate forecast possible only on 1 … 2 points onward).
Extracellular vesicles as a novel photosensitive drug delivery system for enhanced photodynamic therapy
Authors: Tong Lingjun , Zhang Sitong , Huang Rong , Yi Huaxi , Wang Jiong-Wei
Published: September 2022

Photodynamic therapy (PDT) is a promising non-invasive therapeutic approach that utilizes photosensitizers (PSs) to generate highly reactive oxygen species (ROS), including singlet oxygen, for removal of targeted cells. PDT has been proven efficacious for the treatment of several diseases, including cancer, cardiovascular disease, inflammatory bowel disease, and diabetic ocular disease. However, the therapeutic efficacy of PDT is limited and often accompanied by side effects, largely due to non-specific delivery of PSs beyond the desired lesion site. Over the past decade, despite various nanoparticular drug delivery systems developed have markedly improved the treatment efficacy while reducing the off-target effects of PSs, concerns over the safety and toxicity of synthetic nanomaterials following intravenous administration are raised. Extracellular vesicles (EVs), a type of nanoparticle released from cells, are emerging as a natural drug delivery system for PSs in light of EV’s potentially low immunogenicity and biocompatibility compared with other nanoparticles. This review aims to provide an overview of the research progress in PS delivery systems and propose EVs as an alternative PS delivery system for PDT. Moreover, the challenges and future perspectives of EVs for PS delivery are discussed.
KRAS protein expression becomes progressively restricted during embryogenesis and in adulthood
Authors: Minati Marie-Albane , Assi Mohamad , Libert Maxime , Cordi Sabine , Lemaigre Frédéric , Jacquemin Patrick
Published: September 2022

KRAS mutants are common in many cancers and wild-type KRAS is essential in development as its absence causes embryonic lethality. Despite this critical role in development and disease, the normal expression pattern of KRAS protein is still largely unknown at the tissue level due to the lack of valid antibodies. To address this issue, we used the citrine-Kras mouse model in which the Citrine-KRAS (Cit-K) fusion protein functions as a validated surrogate of endogenous KRAS protein that can be detected on tissue sections by immunolabeling with a GFP antibody. In the embryo, we found expression of KRAS protein in a wide range of organs and tissues. This expression tends to decrease near birth, mainly in mesenchymal cells. During transition to the adult stage, the dynamics of KRAS protein expression vary among organs and detection of KRAS becomes restricted to specific cell types. Furthermore, we found that steady state KRAS protein expression is detectable at the cell membrane and in the cytoplasm and that this subcellular partitioning differed among cell types. Our results reveal hitherto unanticipated dynamics in developmental, tissular, cell-specific and subcellular expression of KRAS protein. They provide insight into the reason why specific cell-types are sensitive to KRAS mutations during cancer initiation.
Novel botanical active component derivatives containing carboxamide and 1,3,4-Thiadiazole thioether moieties: Design, synthesis, and inhibitory activity
Authors: Li Pei , Chen Cong , Zhu Rongxi , Yang Guixia , Xu Min , Wan Guanghua , Wang Xiang
Published: September 2022

In this study, using the botanical active components of carvacrol, thymol, guaiacol, and sesamol as the lead structures, 19 novel botanical active component derivatives containing carboxamide and 1,3,4-thiadiazole thioether moieties (5a−5s) were synthesized and structurally characterized by 1H NMR, 13C NMR, and HRMS. The antibacterial bioassay results in vitro showed that compound 2-(2-methoxyphenoxy)-N-(5-(methylthio)-1,3,4-thiadiazol-2-yl)acetamide (5k) revealed excellent inhibitory activities against Xanthomonas axonopodis pv. citri (Xac) and Xanthomonas oryzae pv. oryzicolaby (Xoc), with the median effective concentration (EC50) values of 22 and 15 μg/ml, respectively, which were even better than those of thiodiazole copper and bismerthiazol. Meanwhile, all the target compounds revealed lower in vitro inhibitory effects on Mucor bainieri (M. bainieri), Mucor fragilis (M. fragilis), and Trichoderma atroviride (T. atroviride), than carbendazim.
The impact of pelvic floor electrical stimulation on vaginal microbiota and immunity
Authors: Zhang Yakun , Yang He , Zhang Chi , Lin Li , Yang Wenlan , Xiong Guangwu , Gao Guolan
Published: September 2022

Pelvic floor electrical stimulation (ES) is an effective treatment for pelvic floor dysfunction. However, the impact of ES on vaginal microbiota and local inflammatory response is yet poorly understood. Therefore, we designed a longitudinal study to investigate the impact of ES on vaginal microbiota and cytokines. A total of 170 participants were recruited into the study at Peking University International Hospital, Beijing, China, from December 2021 to April 2022. They were divided into two groups concerning the follow-up: long-term cohort (n = 147) following up to seven treatment sessions and short-term cohort (n = 23) following up to 7 h after a 30-min treatment. Paired vaginal discharge samples were collected from 134 individuals. Vaginal microbiota was characterized by 16S rRNA sequencing, and local cytokines concentrations were detected by the cytometric bead array method. A significant increase in the relative abundance of Lactobacillus spp. was observed after ES treatment (P < 0.001). In addition, L. crispatus (P = 0.012) and L. gasseri (P = 0.011) also increased significantly. Reduced microbial diversity was observed in the vaginal microbiota after the treatment. In the long-term cohort, a significant downregulation of IFN-γ, IL-2, IL-4, IL-10, IL-17A, and TNF-α was compared with baseline. However, the short-term cohort presented with an elevated IL-6 level at 7 h after the treatment. In conclusion, this study suggested that transvaginal electrical stimulation might help to restore and maintain a healthy vaginal microbiota dominated by Lactobacillus, reducing the risk of vaginal inflammation.
Refractory Helicobacter pylori infection and the gastric microbiota
Authors: Liu Dongsheng , Wang Jinyun , Xie Yong
Published: September 2022

Background

Curing refractory Helicobacter pylori infection is difficult. In addition, there is currently no research on the gastric microbiota of refractory H. pylori infection.

Methods

We designed a clinical retrospective study involving 32 subjects divided into three groups: 1. nAGHp.a, treatment-naïve patients with H. pylori infection; 2. nAGHp.b, H. pylori-negative patients; and 3. EFHp.a, patients with refractory H. pylori infection. Gastric mucosal samples from the biobank of our research center were collected for 16S rRNA sequencing analysis and bacterial functions were predicted via PICRUSt.

Results

There were significant differences between the H. pylori- positive group and the H. pylori-negative group in species diversity, gastric microbiota structure, and bacterial function. The beneficial Lactobacillus in the H. pylori-positive group were significantly enriched compared with those in the refractory H. pylori infection group. The bacterial interaction network diagram suggested that the microbiota interactions in the refractory H. pylori infection group decreased. The gastric microbiota of the refractory H. pylori infection group was enriched in the pathways of metabolism and infectious diseases (energy metabolism, bacterial secretion system, glutathione metabolism, protein folding and associated processing, sulphur metabolism, membrane and intracellular structural molecules, lipopolysaccharide biosynthesis, ubiquinone and other terpenoid-quinone biosynthesis, inorganic ion transport and metabolism, and metabolism of cofactors and vitamins) when compared with the H. pylori-positive group without treatment based on PICRUSt analysis.

Conclusion

Significant alterations occurred in the gastric microbiota when eradication of H. pylori failed multiple times. A history of eradication of multiple H. pylori infections leads to an imbalance in the gastric mucosal microbiota to a certain extent, which was mainly reflected in the inhibition of the growth of beneficial Lactobacillus in the stomach. Patients with refractory H. pylori infection may be at a higher risk of developing gastric cancer than other H. pylori-positive patients.