bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic efficacy of a K5-specific phage and depolymerase against Klebsiella pneumoniae in a mouse model of infection
Authors: Li Pei , Guo Genglin , Zheng Xiangkuan , Xu Sixiang , Zhou Yu , Qin Xiayan , Hu Zimeng , Yu Yanfei , Tan Zhongming , Ma Jiale , Chen Long , Zhang Wei
Published: May 2024

Klebsiella pneumoniae has become one of the most intractable gram-negative pathogens infecting humans and animals due to its severe antibiotic resistance. Bacteriophages and protein products derived from them are receiving increasing amounts of attention as potential alternatives to antibiotics. In this study, we isolated and investigated the characteristics of a new lytic phage, P1011, which lyses K5 K. pneumoniae specifically among 26 serotypes. The K5-specific capsular polysaccharide-degrading depolymerase dep1011 was identified and expressed. By establishing murine infection models using bovine strain B16 (capable of supporting phage proliferation) and human strain KP181 (incapable of sustaining phage expansion), we explored the safety and efficacy of phage and dep1011 treatments against K5 K. pneumoniae. Phage P1011 resulted in a 60% survival rate of the mice challenged with K. pneumoniae supporting phage multiplication, concurrently lowering the bacterial burden in their blood, liver, and lungs. Unexpectedly, even when confronted with bacteria impervious to phage multiplication, phage therapy markedly decreased the number of viable organisms. The protective efficacy of the depolymerase was significantly better than that of the phage. The depolymerase achieved 100% survival in both treatment groups regardless of phage propagation compatibility. These findings indicated that P1011 and dep1011 might be used as potential antibacterial agents to control K5 K. pneumoniae infection.
The haemagglutinin–neuraminidase protein of velogenic Newcastle disease virus enhances viral infection through NF-κB-mediated programmed cell death
Authors: Lu Xiaolong , Zhan Tiansong , Zhou Qiwen , Yang Wenhao , Liu Kaituo , Chen Yu , Gao Ruyi , Hu Jiao , Gu Min , Hu Shunlin , Jiao Xin-an , Wang Xiaoquan , Liu Xiufan , Liu Xiaowen
Published: May 2024

The haemagglutinin–neuraminidase (HN) protein, a vital membrane glycoprotein, plays a pivotal role in the pathogenesis of Newcastle disease virus (NDV). Previously, we demonstrated that a mutation in the HN protein is essential for the enhanced virulence of JS/7/05/Ch, a velogenic variant NDV strain originating from the mesogenic vaccine strain Mukteswar. Here, we explored the effects of the HN protein during viral infection in vitro using three viruses: JS/7/05/Ch, Mukteswar, and an HN-replacement chimeric NDV, JS/MukHN. Through microscopic observation, CCK-8, and LDH release assays, we demonstrated that compared with Mukteswar and JS/MukHN, JS/7/05/Ch intensified the cellular damage and mortality attributed to the mutant HN protein. Furthermore, JS/7/05/Ch induced greater levels of apoptosis, as evidenced by the activation of caspase-3/8/9. Moreover, JS/7/05/Ch promoted autophagy, leading to increased autophagosome formation and autophagic flux. Subsequent pharmacological experiments revealed that inhibition of apoptosis and autophagy significantly impacted virus replication and cell viability in the JS/7/05/Ch-infected group, whereas less significant effects were observed in the other two infected groups. Notably, the mutant HN protein enhanced JS/7/05/Ch-induced apoptosis and autophagy by suppressing NF-κB activation, while it mitigated the effects of NF-κB on NDV infection. Overall, our study offers novel insights into the mechanisms underlying the increased virulence of NDV and serves as a reference for the development of vaccines.
MYB4 is the best candidate transcription factor involved in pinosylvin stilbene biosynthesis in Pinus strobus L. cells by fungal elicitor treatment
Authors: Kim Yi Rae , Moon Young Bum , Choi Han Bin , Han Jung Yeon , Choi Han Suk , Shim Sangrea , Choi Yong Eui
Published: May 2024

Key message

Dihydropinosylvin monomethyl ether (DPME) and pinosylvin monomethyl ether (PME) are pinosylvin derivatives that show high nematicidal activity against pine wood nematodes (PWNs). Here, we found that fungal elicitor treatment boosted the production of DPME and PME in cultured Pinus strobus L. cells and investigated the transcription factors (TFs) regulating the genes in the pinosylvin stilbenoid biosynthesis pathway.

Context

The discovery of TFs involved in the synthesis of DPME and PME provides an important clue to understanding the pinosylvin stilbenoid synthesis in pine plants.

Aims

We investigated the best fungal elicitor for the production of DPME and PME and the transcriptional activities of genes involved in PME and DPME biosynthesis in P. strobus L. cells after fungal elicitor treatment.

Methods

The content of DPME and PME in P. strobus cells was examined after treatment with fungal elicitors prepared from seven different species of fungi. Moreover, the role of fungal elicitors in the transcriptional activity of genes involved in DPME and PME biosynthesis was investigated by transcriptome analysis using RNA sequencing.

Results

Penicillium chrysogenum Thorn was the most efficient fungal elicitor for the production of DPME and PME in P. strobus cells among the other fungal species. The accumulation of DPME and PME in P. strobus cells after P. chrysogenum elicitor treatment increased 12.7-fold and 23.7-fold, respectively, compared to the control. Transcriptome analysis revealed that fungal elicitor treatment resulted in enhanced transcription of the PAL, 4CL, STS, PMT, and ACC genes, which are involved in PME and DPME biosynthesis. Some transcription factors belonging to the bHLH, MYB, WRKY, and ERF families showed a high transcription rate after fungal elicitor treatment.

Conclusions

We found that the fungal elicitor is a strong inducer of the accumulation of pinosylvin derivatives in the cells of P. strobus. We selected one unigene (c133966_g3_i1 in the MYB family) as the best candidate TF that regulates the DPME and PME biosynthesis in P. strobus by transcriptome analysis.
Boosting self-efficacy and improving practices for smoking prevention and cessation among South American cancer care providers with a web-based algorithm
Authors: Tamí-Maury Irene , Tundealao Samuel , Noé-Díaz Valeri , Garcia Esperanza , Diaz Vilma , Meier Jennie , Dani Mira , Vidaurre Tatiana
Published: May 2024

Background

Digital technologies have positively impacted the availability and usability of clinical algorithms through the advancement in mobile health. Therefore, this study aimed to determine if a web-based algorithm designed to support the decision-making process of cancer care providers (CCPs) differentially impacted their self-reported self-efficacy and practices for providing smoking prevention and cessation services in Peru and Colombia.

Methods

A simple decision-making tree algorithm was built in REDCap using information from an extensive review of the currently available smoking prevention and cessation resources. We employed a pre-post study design with a mixed-methods approach among 53 CCPs in Peru and Colombia for pilot-testing the web-based algorithm during a 3-month period. Wilcoxon signed-rank test was used to compare the CCPs’ self-efficacy and practices before and after using the web-based algorithm. The usability of the web-based algorithm was quantitatively measured with the system usability scale (SUS), as well as qualitatively through the analysis of four focus groups conducted among the participating CCPs.

Results

The pre-post assessments indicated that the CCPs significantly improved their self-efficacy and practices toward smoking prevention and cessation services after using the web-based algorithm. The overall average SUS score obtained among study participants was 82.9 (± 9.33) [Peru 81.5; Colombia 84.1]. After completing the qualitative analysis of the focus groups transcripts, four themes emerged: limited resources currently available for smoking prevention and cessation in oncology settings, merits of the web-based algorithm, challenges with the web-based algorithm, and suggestions for improving this web-based decision-making tool.

Conclusion

The web-based algorithm showed high usability and was well-received by the CCPs in Colombia and Peru, promoting a preliminary improvement in their smoking prevention and cessation self-efficacy and practices.
An intelligent model to decode students’ behavioral states in physical education using back propagation neural network and Hidden Markov Model
Authors: Li Liyan
Published: May 2024

This paper highlights the need for intelligent analysis of students’ behavioral states in physical education tasks. The hand-ring inertial data is used to identify students’ motion sequence states. First, statistical feature extraction is performed based on the acceleration and angular velocity data collected from the bracelet. After completing the filtering and noise reduction of the data, we perform feature extraction by Back Propagation Neural Network (BPNN) and use the sliding window method for analysis. Finally, the classification capability of the model sequence is enhanced by the Hidden Markov Model (HMM). The experimental results indicate that the classification accuracy of student action sequences in physical education exceeds 96% after optimization by the HMM method. This provides intelligent means and new ideas for future student state recognition in physical education and teaching reform.
Reconstructing and tracing the evolution of the road networks in the Haidai region of China during the Bronze and Early Iron Ages
Authors: Yong Heng , Jia Xin , Li Sijin , Yang Lin , Lee Harry F. , Tang Guoan
Published: May 2024

Reconstructing ancient transportation networks is critical to studying past human mobility patterns. China’s Haidai region was a thriving political and economic hub during the Bronze and Early Iron Ages. We used GIS spatial analysis techniques to build a “Settlement Interaction Model” based on archaeological data from the Haidai region during the Bronze and Early Iron Age (Shang Dynasty, Western Zhou Dynasty, Spring & Autumn Period, and Warring States period). The eight-level road network maps with traffic attributes were distinguished based on topography and settlement size. The total lengths of the road networks were estimated to be 19,112 km in the Shang Dynasty, 35,269 km in the Western Zhou Dynasty, 51,555 km in the Spring & Autumn Period, and 77,456 km in the Warring States Period, with the average road flows of 6.6, 31.7, 42.8, and 75.5, respectively. The Z score and one-sample t-test (p < 0.01) confirmed the reliability of the reconstructed road networks. The Shang Dynasty saw the sporadic appearance of simple road routes. More complex routes emerged during the Western Zhou Dynasty and Spring & Autumn Period. The road networks were finally built during the Warring States Period. The development of road networks was closely related to population growth and urbanization. Exploring methods for reconstructing road networks may help us uncover ancient road networks and better understand ancient cultural exchanges.
Superiority of 18F-FAPI-42 PET/CT in the detection of primary tumor and management of appendiceal neoplasm to 18F-FDG PET/CT and CE-CT
Authors: Dong Ye , Huang Shun , Wu Hubing , Cao Min , Huang Yanchao , Tang Ganghua , Zhou Wenlan
Published: May 2024

Background

In the present study, we investigated the value of 18F-fibroblast-activation protein inhibitor (FAPI) positron emission tomography/computed tomography (18F-FAPI-42 PET/CT) to preoperative evaluations of appendiceal neoplasms and management for patients.

Methods

This single-center retrospective clinical study, including 16 untreated and 6 treated patients, was performed from January 2022 to May 2023 at Southern Medical University Nanfang Hospital. Histopathologic examination and imaging follow-up served as the reference standard. 18F-FAPI-42 PET/CT was compared to 18F-fluorodeoxyglucose (18F-FDG) PET/CT and contrast-enhanced CT (CE-CT) in terms of maximal standardized uptake value (SUVmax), diagnostic efficacy and impact on treatment decisions.

Results

The accurate detection of primary tumors and peritoneal metastases were improved from 28.6% (4/14) and 50% (8/16) for CE-CT, and 43.8% (7/16) and 85.0% (17/20) for 18F-FDG PET/CT, to 87.5% (14/16) and 100% (20/20) for 18F-FAPI-42 PET/CT. Compared to 18F-FDG PET/CT, 18F-FAPI-42 PET/CT detected more regions infiltrated by peritoneal metastases (108 vs. 43), thus produced a higher peritoneal cancer index (PCI) score (median PCI: 12 vs. 5, P < 0.01). 18F-FAPI-42 PET/CT changed the intended treatment plans in 35.7% (5/14) of patients compared to CE-CT and 25% (4/16) of patients compared to 18F-FDG PET/CT but did not improve the management of patients with recurrent tumors.

Conclusions

The present study revealed that 18F-FAPI-42 PET/CT can supplement CE-CT and 18F-FDG PET/CT to provide a more accurate detection of appendiceal neoplasms and improved treatment decision making for patients.
Decentralization and immunization program in a single-party state: the case of the Lao People’s Democratic Republic
Authors: Viphonephom Phonevilay , Kounnavong Sengchanh , Reinharz Daniel
Published: May 2024

Background

The Lao People’s Democratic Republic (Lao PDR), a lower-middle-income country, lags behind other Southeast Asian countries in immunization coverage for children under two years of age. The organization of health services is a key determinant of the functionality of immunization programs. However, this aspect, and in particular its decentralization component of the healthcare system, has never been studied.

Methods

A case study in the Lao National Immunization Program was performed using a neo-institutional theory-based conceptual framework, highlighting the structure (rules, laws, resources, etc.) and interpretative schemes (dominant beliefs and ideas) that underlie the state of decentralization of the healthcare system that support the conduct of the immunization program. Twenty-two semi-structured interviews were conducted with representative actors from various government levels, external donors, and civil society, in four provinces. Data were complemented with information retrieved from relevant documents.

Results

The Lao healthcare system has a deconcentrated form of decentralization. It has a largely centralized structure, albeit with certain measures promoting the decentralization of its immunization programs. The structure underlying the state of centralization of immunization services provided is coherent with a shared dominant interpretive scheme. However, the rapid economic, technical, and educational changes affecting the country suggest that the coherence between structure and interpretative schemes is bound to change.

Conclusion

Unprecedented opportunities to access quality higher education and the use of social networks are factors in Lao PDR that could affect the distribution of responsibilities of the different levels of government for public health programs such as the National Immunization Program.
Hope in hardship: charting a new course for mental health in Afghanistan
Authors: Tay Alvin Kuowei
Published: May 2024

The long legacy of upheavals and deprivations in Afghanistan and the associated mental health impacts on its people are well documented. A systematic review undertaken by Alemi et al (2023) presents the most comprehensive synthesis to date on this topic. Drawing on their findings, this editorial examines the complex mental health and psychosocial challenges confronted by neglected vulnerable groups such as pregnant and postnatal women, LGBTQ individuals, older adults, ethnic minority groups and Afghan refugees living overseas. It explores the potential challenges in rebuilding a resilient mental health system following the mass exodus of Afghanis. It calls for a whole-of-society approach that extends beyond clinical interventions to address the broader sociocultural and economic factors influencing mental health.
Treatment condition as a moderator and change in trait mindfulness as a mediator of a brief mindfulness ecological momentary intervention for generalized anxiety disorder
Authors: Zainal Nur Hani , Newman Michelle G.
Published: May 2024

Background

Theories propose that judgment of and reactivity to inner experiences are mediators of the effect of mindfulness-based interventions on generalized anxiety disorder (GAD). However, no study has tested such theories using brief, mindfulness ecological momentary intervention (MEMI). We thus tested these theories using a 14-day MEMI versus self-monitoring app (SM) control for GAD.

Methods

Participants (N = 110) completed self-reports of trait mindfulness (Five Facet Mindfulness Questionnaire), GAD severity (GAD-Questionnaire-IV), and trait perseverative cognitions (Perseverative Cognitions Questionnaire) at prerandomization, posttreatment, and 1-month follow-up (1MFU). Counterfactual mediation analyses with temporal precedence were conducted.

Results

Improvement in pre–post mindfulness domains (acceptance of emotions, describing feelings accurately, acting with awareness, judgment of inner experience, and reactivity to inner experience) predicted pre-1MFU reduction in GAD severity and pre-1MFU reduction in trait perseverative cognitions from MEMI but not SM. MEMI reduced pre–post reactivity to inner experiences (but not other mindfulness domains) significantly more than SM. Only reduced pre–post reactivity significantly mediated stronger efficacy of MEMI over SM on pre-1MFU reductions in GAD severity (indirect effect: β = −2.970 [−5.034, −0.904],p = .008;bpath: β = −3.313 [−6.350, −0.276],p = .033; percentage mediated: 30.5%) and trait perseverative cognitions (indirect effect: β = −0.153 [−0.254, −0.044],p = .008;bpath: β = −0.145 [−0.260, −0.030],p = .014; percentage mediated: 42.7%). Other trait mindfulness domains were non-significant mediators.

Conclusions

Reactivity to inner experience might be a mindfulness-based intervention change mechanism and should be targeted to optimize brief MEMIs for GAD.
Mapping the Evidence on the Impact of mHealth Interventions on Patient-Reported Outcomes in Patients With Breast Cancer: A Systematic Review
Authors: Frid Santiago , Amat-Fernández Clara , Fuentes-Expósito María Ángeles , Muñoz-Mateu Montserrat , Valachis Antonis , Sisó-Almirall Antoni , Grau-Corral Immaculada
Published: May 2024

PURPOSE

To comprehensively synthesize the existing evidence concerning mHealth interventions for patients with breast cancer (BC).

DESIGN

On July 30, 2023, we searched PubMed, PsycINFO, and Google Scholar for articles using the following inclusion criteria: evaluation of mHealth interventions in patients with cancer, at least 30 participants with BC, randomized control trials or prospective pre-post studies, determinants of health (patient-reported outcomes [PROs] and quality of life [QoL]) as primary outcomes, interventions lasting at least 8 weeks, publication after January 2015. Publications were excluded if they evaluated telehealth or used web-based software for desktop devices only. The quality of the included studies was analyzed with the Cochrane Collaboration Risk of Bias Tool and the Methodological Index for Non-Randomized Studies.

RESULTS

We included 30 studies (20 focused on BC), encompassing 5,691 patients with cancer (median 113, IQR, 135.5). Among these, 3,606 had BC (median 99, IQR, 75). All studies contained multiple interventions, including physical activity, tailored information for self-management of the disease, and symptom tracker. Interventions showed better results on self-efficacy (3/3), QoL (10/14), and physical activity (5/7). Lifestyle programs (3/3), expert consulting (4/4), and tailored information (10/11) yielded the best results. Apps with interactive support had a higher rate of positive findings, while interventions targeted to survivors showed worse results. mHealth tools were not available to the public in most of the studies (17/30).

CONCLUSION

mHealth interventions yielded heterogeneous results on different outcomes. Identifying lack of evidence on clinical scenarios (eg, patients undergoing systemic therapy other than chemotherapy) could aid in refining strategic planning for forthcoming research endeavors within this field.
Should All Patients With Stage IE Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Receive Antibiotic Eradication Therapy for Helicobacter pylori?
Authors: Laoruangroj Chonlada , Habermann Thomas M. , Wang Yucai , King Rebecca L. , Lester Scott C. , Thompson Carrie A. , Witzig Thomas E.
Published: May 2024

PURPOSE

H. pylori eradication therapy (HPE) can lead to tumor regression in H. pylori–positive (HPP) gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, some patients do not have detectable H. pylori (HP) infection ( H. pylori–negative [HPN]) and the guidelines differ in their initial approach to HPN patients. The National Comprehensive Cancer Network (NCCN) recommends proceeding to radiation therapy, whereas European Society for Medical Oncology suggests HPE for every patient, even those who are HPN. To address this issue, we evaluated the effectiveness of HPE in limited-stage gastric MALT lymphoma.

MATERIALS AND METHODS

We retrospectively reviewed patients newly diagnosed with stage IE gastric MALT lymphoma between January 2002 and December 2022. The primary outcome was the complete remission (CR) rate defined as no macroscopic findings of lymphoma and negative gastric biopsy at the follow-up gastric endoscopy.

RESULTS

Fifty-two patients were reviewed, and HP infection was detected in 19 (36.5%) patients—14 by immunostaining, three by serology, and one each by stool antigen and urea breath test. All 19 HPP and eight of the 33 HPN patients received HPE treatment. The CR rate was 63% (12/19) in HPP patients and 13% (1/8) in HPN patients ( P = .033). After a median follow-up of 89.7 months, only two of the 12 HPP patients achieving CR have relapsed; the one HPN patient who received HPE remains in CR at 12+ months.

CONCLUSION

For limited-stage HPP gastric MALT lymphoma, HPE is an effective and durable first-line treatment and should be used. For HPN patients, the CR rate with HPE is very low in our experience and is thus in support of the NCCN guideline.
Optimization of Hypericum Perforatum Microencapsulation Process by Spray Drying Method
Authors: Seyrekoğlu Fadime , Temiz Hasan , Eser Ferda , Yıldırım Cengiz
Published: May 2024

Hypericum perforatum (HP) contains valuable and beneficial bioactive compounds that have been used to treat or prevent several illnesses. Encapsulation technology offers protection of the active compounds and facilitates to expose of the biologically active compounds in a controlled mechanism. Microcapsulation of the hydroalcoholic gum arabic and maltodextrin have hot been used as wall materials in the encapsulation of HP extract. Therefore, the optimum microencapsulation parameters of Hypericum perforatum (HP) hydroalcoholic extract were determined using response surface methodology (RSM) for the evaluation of HP extract. Three levels of three independent variables were screened using the one-way ANOVA. Five responses were monitored, including total phenolic content (TPC), 2,2-Diphenyl-1-picrylhydrazyl (DPPH), carr index (CI), hausner ratio (HR), and solubility. Optimum drying conditions for Hypericum perforatum microcapsules (HPMs) were determined: 180 °C for inlet air temperature, 1.04/1 for ratio of maltodextrin to gum arabic (w/w), and 1.98/1 for coating to core material ratio (w/w). TPC, antioxidant activity, CI, HR, and solubility values were specified as 316.531 (mg/g GAE), 81.912%, 6.074, 1.066, and 35.017%, respectively, under the optimized conditions. The major compounds of Hypericum perforatum (hypericin and pseudohypericin) extract were determined as 4.19 μg/g microcapsule and 15.09 μg/g microcapsule, respectively. Scanning electron microscope (SEM) analysis revealed that the mean particle diameter of the HPMs was 20.36 µm. Based on these results, microencapsulation of HPMs by spray drying is a viable technique which protects the bioactive compounds of HP leaves, facilitating its application in the pharmaceutical, cosmetic, and food industries.

Graphical Abstract
Smartphone applications are used for self-management, telerehabilitation, evaluation and data collection in low back pain healthcare: a scoping review
Authors: Dobija Lech , Lechauve Jean-Baptiste , Mbony-Irankunda Didier , Plan-Paquet Anne , Dupeyron Arnaud , Coudeyre Emmanuel
Published: May 2024

Background Smartphone use has grown in providing healthcare for patients with low back pain (LBP), but the literature lacks an analysis of the use of smartphone apps. This scoping review aimed to identify current areas of smartphone apps use for managing LBP. We also aimed to evaluate the current status of the effectiveness or scientific validity of such use and determine perspectives for their potential development. Methods We searched PubMed, PEDro and Embase for articles published in English up to May 3rd, 2021 that investigated smartphone use for LBP healthcare and their purpose. All types of study design were accepted. Studies concerning telemedicine or telerehabilitation but without use of a smartphone were not included. The same search strategy was performed by two researchers independently and a third researcher validated the synthesis of the included studies. Results We included 43 articles: randomised controlled trials (RCTs) (n=12), study protocols (n=6), reliability/validity studies (n=6), systematic reviews (n=7), cohort studies (n=4), qualitative studies (n=6), and case series (n=1). The purposes of the smartphone app were for 1) evaluation, 2) telerehabilitation, 3) self-management, and 4) data collection. Self-management was the most-studied use, showing promising results derived from moderate- to good-quality RCTs for patients with chronic LBP and patients after spinal surgery. Promising results exist regarding evaluation and data collection use and contradictory results regarding measurement use. Conclusions This scoping review revealed a notable interest in the scientific literatures regarding the use of smartphone apps for LBP patients. The identified purposes point to current scientific status and perspectives for further studies including RCTs and systematic reviews targeting specific usage.
Med-ImageTools: An open-source Python package for robust data processing pipelines and curating medical imaging data
Authors: Kim Sejin , Kazmierski Michal , Qu Kevin , Peoples Jacob , Nakano Minoru , Ramanathan Vishwesh , Marsilla Joseph , Welch Mattea , Simpson Amber , Haibe-Kains Benjamin
Published: May 2024

Background Machine learning and AI promise to revolutionize the way we leverage medical imaging data for improving care but require large datasets to train computational models that can be implemented in clinical practice. However, processing large and complex medical imaging datasets remains an open challenge. Methods To address this issue, we developed Med-ImageTools, a new Python open-source software package to automate data curation and processing while allowing researchers to share their data processing configurations more easily, lowering the barrier for other researchers to reproduce published works. Use cases We have demonstrated the efficiency of Med-ImageTools across three different datasets, resulting in significantly reduced processing times. Conclusions The AutoPipeline feature will improve the accessibility of raw clinical datasets on public archives, such as the Cancer Imaging Archive (TCIA), the largest public repository of cancer imaging, allowing machine learning researchers to process analysis-ready formats without requiring deep domain knowledge.
Intention for internal whistleblowing to report sexual violence in higher education institutions: a Nigerian national study
Authors: Ogunfowokan Adesola A. , Garba Saleh N. , Orisadare Monica A. , Adeleke Ayobami G. , Samson-Akpan Patience E. , Olatubi Mathew O. , Salau Omowumi R. , Titilayo Ayotunde
Published: May 2024

Background Sexual violence is prevalent in higher education institutions in Nigeria and stakeholders have encouraged staff and students to blow the whistle whenever they fall victim to or are aware of any sexual violence case. However, there is lack of data about whether the staff and students of these institutions have the intention to blow the whistle internally (within the institution) or not. There is also a lack of data on the existing reporting mechanisms or preferred whistleblowing mechanisms in these institutions. These have hindered the analysis of stakeholders’ opinions on this topic. Methods This data note presents a comprehensive quantitative and qualitative data set collected from staff and students of three categories of government owned higher education institutions (Universities, Polytechnics, Colleges of Education) in Nigeria. Data collection was between February and December, 2021, during which quantitative data were collected from 21,937 students and 3,108 staff. Qualitatively, 138 students and 111 staff participated in a total of 35 focus group discussion sessions. The study provides unique information on respondents’ attitude, self-efficacy, and subjective norm to sexual violence whistleblowing. It also provides information on self-reported sexual violence experiences, whistleblowing intention, reporting systems in higher institutions and the preferred sexual violence whistleblowing mechanisms. Conclusions In this data note, we provide a detailed account of the variables in the dataset and then highlight the potential of this study to contribute to improved sexual violence reporting in higher education institutions, thereby reducing the occurrence of the social menace.
How the COVID-19 pandemic changed stakeholder engagement processes in sustainability research in the long-term
Authors: Süsser Diana , Schibline Amanda , Ceglarz Andrzej , Lilliestam Johan , Stavrakas Vassilis , Schweizer Pia-Johanna
Published: May 2024

Background The COVID-19 pandemic affected stakeholder engagement in sustainability research projects in many ways. But which effects appear permanent today, after the pandemic ended? Methods To address this, we interviewed researchers and stakeholders and carried out a survey among European sustainability research projects in 2022. Results We find that the pandemic years disrupted stakeholder-based research, also with lasting effects. The forced shift to online modes showed how digital engagement can bring benefits in terms of easier and more efficient stakeholder engagement, but also that important aspects are lost, particularly regarding intensity of collaboration and depth of insights. Whether to go online or stay offline depends largely on the research objective, which stakeholders to involve, and how well researchers and stakeholders already know each other. Most researchers and stakeholders want to continue online collaboration in the long term, especially those with positive online collaboration experiences from the pandemic years. Conclusions The pandemic has a long-term impact on stakeholder engagement in research; online engagement cannot replace all benefit of previous in-person interactions with stakeholders, but it has led to digital innovations and expanded the engagement portfolio. Our research has provided qualitative insights into the impact of the pandemic on stakeholder engagement in various sustainability research projects and the implications for the long-term future that are relevant to researchers and funding agencies.
Environmental factors and daily suicides: a time series analysis
Authors: Kacem Imene , Ouahchi Ines , Jedidi Maher , Nakhli Rania , Maoua Maher , Gharsallaoui Sarra , Soussi Mohamed , Fki Amen , Taieb Dalila , Chatti Souhail , Naija Walid , Aloui Asma , Kahloul Mohamed
Published: May 2024

Background This study investigated the association between weather, air pollution, and suicide risk in Sousse. Methods A two-time series analysis examined suicide cases recorded in the forensic service of Farhat Hached University Hospital of Sousse, confirmed by autopsy, over seven years (2010-2016). Climate data were retrieved from the Monastir-Airport weather station, and air pollution data were obtained from the National Agency for Environmental Protection’s modelling platform. Results During the study period, 118 suicides were recorded, with the highest number (19.5%) occurring in 2012. Multiple binary logistic regression analysis revealed that autumn and a decline in NH3 were independently associated with a decreased risk of suicide (p=0.045; ORa: 0.57 CI95% [0.33-0.98], p= 0.009; ORa: 0.24 CI95% [0.08-0.71], respectively). Conversely, a 1 ppm increase in PM10 was associated with a 2.5% increase in suicide risk (p<10-3; ORa: 1.02 CI95% [1.01-1.03]). Conclusions Environmental factors, including seasonality and air quality, may provide valuable insights into suicide risks. Understanding the influence of these factors may have implications in preventive strategies.
Living systematic review and meta-analysis of plasma-concentrations of antipsychotic drugs in carriers and non-carriers of variant CYP450 genotypes: Living systematic review protocol
Authors: Milosavljević Filip , Leucht Stefan
Published: May 2024

Introduction Carriers of variant alleles of genes that encode liver CYP450 and UGT enzymes may experience abnormal plasma levels of antipsychotics and, consequently, worse efficacy or tolerability. Although pharmacogenomics is a rapidly developing field, current guidelines often rely on limited, underpowered evidence. We have previously demonstrated that meta-analysis is a viable strategy for overcoming this problem. Here, we propose a project that will expand our previous work and create a living systematic review and meta-analysis of drug plasma level differences between carriers and non-carriers of variant genotype-predicted phenotypes for every pharmacokinetic drug-gene interaction relevant to commonly used antipsychotic drugs. Protocol First, a baseline systematic review and meta-analysis will be conducted by searching for observational pharmacogenomics-pharmacokinetic studies. Data on dose-adjusted drug plasma levels will be extracted, and participants will be grouped based on their genotype for each drug-gene pair separately. Differences in plasma drug levels between different phenotypes will be compared using a random-effect ratio-of-means meta-analysis. The risk of bias will be assessed using ROBINS-I, and the certainty of evidence will be assessed using GRADE. Following the establishment of baseline results, the literature search will be re-run at least once every six months, and the baseline data will be updated and re-evaluated as new evidence is published. A freely available website will be designated to present up-to-date results and conclusions. Discussion This systematic review will provide evidence-based results that are continuously updated with evidence as it emerges in the rapidly developing field of pharmacogenomics. These results may help psychiatrists in their decision-making, as clinicians are becoming increasingly aware of the patients’ genetic data as testing becomes more widespread and cheaper. In addition, the results may serve as a scientific basis for the development of evidence-based pharmacogenomics algorithms for personalized dosing of antipsychotics to mitigate potentially harmful drug-gene interactions.
Efficacy and safety of various drug combinations in treating plaque Psoriasis: A meta-analysis
Authors: Snehasis Nayak , Zafar Sayed , Herve Ngabo , Siri Pendyala , Haji Ali Karshe
Published: May 2024

Background Psoriasis, a chronic inflammatory disease affecting the skin, joints, and nails (2-3% worldwide), significantly affects quality of life. Genetic and environmental factors also play key roles. Topical corticosteroids, calcineurin inhibitors, and oral corticosteroids help to manage plaque psoriasis symptoms, but combination therapies might offer greater effectiveness and improved safety profiles. These combinations could potentially reduce medication dosages and side effects in patients. Objective To assess the efficacy and safety of various drug combinations over conventional monotherapies in the treatment of moderate to severe plaque psoriasis, which incorporates palmoplantar psoriasis and psoriasis vulgaris, by discovering and utilizing research articles comprising the same or similar variables as PASI 75 and evaluating the information using RevMan v5.4.1. Method We reviewed the efficacy and safety of combination therapy vs. monotherapy/placebo for moderate-to-severe plaque psoriasis (palmoplantar and vulgaris) using PASI 75 via RevMan v5.4.1. Risk of bias assessment and funnel plots were employed to assess the heterogeneity of each paper. Inclusion criteria – Publications < 20yrs, RCTs, plaque/palmoplantar/psoriasis vulgaris; exclusion criteria – Guttate/arthritic psoriasis, pediatric and pregnant individuals, publications > 20 yrs. Results Seventeen studies were analyzed, comprising a total of 2291 patients (n=1147 with combination regimens and n=1144 with control regimen in the analysis). A significant PASI 75- response was observed in the pioglitazone combination subgroup as compared to placebo (OR=4.92,95% CI 2.19-11.05, P = 0.0001); methotrexate combination subgroup as compared to placebo (OR=2.56, 95% CI 1.67-3.94, P< 0.0001) test of subgroup differences showed P= 0.14, I2= 34%. Incidence rate of abnormality in levels of liver enzymes (OR=1.89,9.5% CI 6.69-5.22, P=0.22), nausea (OR=1.28,95% CI 0.77-2.14, P=0.34), headache (OR=1.28,95% CI 0.77-2.14, P=0.58), fatigue (OR=0.89, 95% CI 0.41-1.90, P=0.45).] Conclusion This study showed that combination therapy is very effective for plaque psoriasis, with promising combinations of pioglitazone. While safety seems similar between the groups, larger studies are needed to determine the long-term effects. These findings suggest that personalized treatment plans could improve outcomes; however, confirmation through larger trials is crucial before wider use. This opens doors to research on optimal combinations for individual patients.
Radosław Kotecki, The Prince and the Prandium: The Motif of the Pre-battle Lunch in the Monk of Sázava’s Account of the Battle of Chlumec (1126)
Authors: Kotecki Radosław
Published: May 2024

This article delves into the Monk of Sázava’s narrative, a late twelfth-century continuation of Cosmas of Prague’s chronicle, which recounts the preparations of Prince Soběslav I of Bohemia for the battle of Chlumec against King Lothar III of Germany on 18 February 1126. In particular, the analysis centres on the motif of the lunch (prandium) that the Bohemian ruler is said to have shared with his men shortly before the battle. Through comparative examination and analysis, the article unveils a contrasting perspective. Unlike numerous narratives that castigate rulers for engaging in a meal prior to battle, the chronicler strategically employed this motif to elevate the character of the prince. This elevation was achieved by infusing the lunch with religious overtones.
Próba analizy oraz interpretacji dramatu Tadeusza Różewicza Rajski ogródek
Authors: Nowak Zuzanna
Published: May 2024

Artykuł zawiera analizę i interpretację dramatu Rajski ogródek Tadeusza Różewicza.
The (Surprising) Sample Optimality of Greedy Procedures for Large-Scale Ranking and Selection
Authors: Li Zaile , Fan Weiwei , Hong L. Jeff
Published: May 2024

Ranking and selection (R&S) aims to select the best alternative with the largest mean performance from a finite set of alternatives. Recently, considerable attention has turned toward the large-scale R&S problem which involves a large number of alternatives. Ideal large-scale R&S procedures should be sample optimal; that is, the total sample size required to deliver an asymptotically nonzero probability of correct selection (PCS) grows at the minimal order (linear order) in the number of alternatives, k. Surprisingly, we discover that the naïve greedy procedure, which keeps sampling the alternative with the largest running average, performs strikingly well and appears sample optimal. To understand this discovery, we develop a new boundary-crossing perspective and prove that the greedy procedure is sample optimal for the scenarios where the best mean maintains at least a positive constant away from all other means as k increases. We further show that the derived PCS lower bound is asymptotically tight for the slippage configuration of means with a common variance. For other scenarios, we consider the probability of good selection and find that the result depends on the growth behavior of the number of good alternatives: if it remains bounded as k increases, the sample optimality still holds; otherwise, the result may change. Moreover, we propose the explore-first greedy procedures by adding an exploration phase to the greedy procedure. The procedures are proven to be sample optimal and consistent under the same assumptions. Last, we numerically investigate the performance of our greedy procedures in solving large-scale R&S problems.

This paper was accepted by Baris Ata, stochastic models and simulation.

Funding: This work was supported by the National Natural Science Foundation of China [Grants 72091211, 72071146, 72161160340].

Supplemental Material: The e-companion and data files are available at https://doi.org/10.1287/mnsc.2023.00694 .
Antecedents of Independent Directors on Joint Venture Boards
Authors: Olie René , Klijn Elko , Reuer Jeffrey J.
Published: May 2024

The presence of independent directors on corporate boards is often seen as an important means of monitoring to address principal-agent problems and of providing external resources and advice to management. In joint ventures (JVs), however, shareholder-management frictions can be lessened by appointing insiders to management and board positions, whereas access to valuable expertise, resources, and networks are provided by the partners themselves. A natural question, then, is why and when do partners appoint independent directors to JV boards? We argue that the appointment of independent directors to joint venture boards is primarily driven by principal-principal conflict considerations, which are unique in the joint venture context compared with conventional widely held corporations. Consistent with this argument, we find that the likelihood of appointing independent directors increases when JVs face more exchange hazards due to the competitive overlap between partners and the broader functional scope of the JV. However, given that JVs also have alternative governance mechanisms to mitigate shareholder conflicts, we also find that more complex contractual agreements can potentially substitute for independent directors on JV boards. Although relational governance is often highlighted as a key facet of JV governance, we do not find such a substitution effect for this supporting governance mechanism. Overall, our research therefore highlights several interesting domain translation issues when applying existing corporate governance insights to the joint venture setting. Our paper concludes with a call for future research on independent directors serving on JV boards, as JVs represent an organizational form that has been neglected in corporate governance research.
Using blockchain to secure biometric healthcare apps
Authors: Kumar Rajeev , Agrawal Alka
Published: May 2024

Tech innovation experts Dr Rajeev Kumar and Dr Alka Agrawal show how blockchain technology can be integrated with biometric apps in the healthcare sector, to protect highly sensitive patient data from cyber-attacks.
Ensuring the privacy of data
Authors: Samoicuk Dominik
Published: May 2024

Most organisations have found themselves sitting on a mountain of data and are tempted to make every possible use of it. However, in an increasingly interconnected, online world, and with the emergence of AI, this poses potential privacy risks. There are some basic steps you can take to ensure that your organisation is not the next source of embarrassing data leaks.
A Mobile Application of a Decision Support System for Ballasting a Floating Dock
Authors: Topalov Andriy , Kondratenko Yuriy , Shevchenko Anatolii , Zaytsev Valeriy , Kozlov Oleksiy , Zaytsev Dmytro , Golikov Volodymyr
Published: May 2024

This paper is devoted to increasing the automation level of docking operations through the development of a mobile application for a decision support system capable of determining the optimal option for loading ballast into floating dock compartments when setting up and launching ships. The proposed decision support system and the mobile application allow implementing effective ballasting of the floating dock before docking the ship based on mathematical calculations of the impact of the ship on the floating dock and the ballasting rules. To test the developed system, the paper presents the functioning of the mobile application for a case of calculation of the docking up process of a 4,100-ton ship. In particular, the load forces of this ship are calculated with a graphical display of the distribution of the influence of 20 sections of the ship on 6 pontoons of the floating dock. As a result, this decision support system with the implemented mobile application has the characteristics of a convenient interface and is easy to operate. It can provide the dockmaster data and suggestions for decision-making, and during its operation, it is actively replenished with a database of the docked up ships.
Bloch gauge symmetry of the semiconductor Bloch equations [Invited]
Authors: Parks A. M. , Moloney J. V. , Brabec T.
Published: May 2024

The semiconductor Bloch equations (SBEs) are a well-established model for optical interactions in condensed matter. In particular, the SBEs in the electromagnetic length gauge preserve the band picture of periodic crystals and thus provide an intuitive and numerically efficient model of high harmonic generation (HHG) in solids. For materials with broken inversion or time-reversal symmetry, the length gauge SBEs involve complex transition dipole moments (TDMs), which depend on the choice of Bloch gauge. The numerical and conceptual complications resulting from this gauge freedom have impeded interpretation and key applications of HHG, such as the tomographic reconstruction of crystal band structure. We derive gauge invariant SBEs (GI-SBEs) that contain only gauge invariant structural quantities: the absolute value of TDMs, the shift vector, and for more than two bands a triple product of TDM phases. The GI-SBEs provide insight into the physics of HHG in solids with broken inversion symmetry, which we demonstrate in gapped graphene.
Crystal growth, polarized spectral properties, and 2.3 µm laser performance of Tm:LuVO4 crystal
Authors: Yu Xiaoxu , Eremeev Kirill , Pan Zhongben , Loiko Pavel , Chu Hongwei , Pan Han , Braud Alain , Camy Patrice , Li Dechun
Published: May 2024

We report on the Czochralski crystal growth, polarized optical spectroscopy, and the first continuous-wave laser operation of 1.5 at.% Tm:LuVO4 crystal on the 3H4 → 3H5 transition. The polarized absorption and stimulated-emission properties of Tm3+ ions in LuVO4 were revised and the crystal-field splitting of the Tm3+ multiplets was determined by low-temperature (12 K) spectroscopy. The maximum stimulated-emission cross-section for the 3H4 → 3H5 transition is 2.48 × 10−20 cm2 at 2363 nm for π-polarization corresponding to an emission bandwidth of 28 nm. Evidence of phonon-assisted emissions of Tm3+ ions above 2 µm is presented. The broadband emission properties of the Tm:LuVO4 crystal make it promising for ultrashort pulse generation. Additionally, pumped by a 796 nm fiber-coupled laser diode, the Tm:LuVO4 laser generated a Watt-level output power at 2279-2295 nm with a slope efficiency of 9.2% and linearly polarized emission (π-polarization).