bluuebunny/crossref_metadata_2025 huggingface dataset:
HUBUNGAN TINGKAT PENGETAHUAN DAN SIKAP IBU TERHADAP TINDAKAN MENCUCI TANGAN DALAM PERAWATAN TALI PUSAT
Authors: Precelia Fransiska  , Rahmi Febriana
Published: January 2025

Perawatan tali pusat pada bayi baru lahir yang benar adalah perawatan tali pusat yang selalu memperhatikan kebersihan dan kesterilan tali pusat. Tujuan penelitian adalah untuk mengetahui hubungan tingkat pengetahuan dan sikap ibu terhadap tindakan mencuci tangan dalam perawatan tali pusat di PMB Umi Kalsum Kota Prabumulih tahun 2024. Metode penelitian bersifat analitik, dengan mengunakan pendekatan Cross Sectional. Populasi penelitian ini adalah seluruh ibu bersalin yang berkunjung di PMB Umi Kalsum saat melakukan penelitian bulan Maret tahun 2024. Pengambilan sampel pada penelitian ini menggunakan metode teknik Accidental Sampling yaitu sebanyak 45 orang. Instrumen penelitian berupa kuesioner. Hasil penelitian berdasarkan analisa bivariat diketahui bahwa dari 33 responden yang memilliki pengetahuan baik terdapat 30 orang (66,7%) melakukan tindakan cuci tangan  sebelum melakukan perawatan tali pusat sedangkan dari 12 responden yang memiliki pengetahuan kurang terdapat 5 responden (11,1%) melakukan tindakan cuci tangan  sebelum melakukan perawatan tali pusat. Dari 37  responden yang memiliki sikap mendukung terdapat 33 orang (73,3%) yang melakukan tindakan cuci tangan  sebelum melakukan perawatan tali pusat sedangkan dari 8 responden yang memiliki sikap tidak mendukung terdapat 2 orang (4,4%) melakukan tindakan cuci tangan  sebelum melakukan perawatan tali pusat. Simpulan ada hubungan yang bermakna antara pengetahuan dengan tindakan cuci tangan  sebelum melakukan perawatan tali pusat dengan nilai Pvalue 0,002< ? 0,05 dan ada hubungan yang bermakna antara sikap ibu dengan tindakan cuci tangan  sebelum melakukan perawatan tali pusat dengan nilai Pvalue 0,000< ? 0,05.
Coral Diseases In The Ambon Waters Of Maluku, Indonesia.
Authors: Pattipeiluhu Shelly Mieke , Ratu Borut Ruku ,   Department of Aquaculture, Faculty of Fisheries and Marine Science University of Pattimura, Rijoly Frederik ,   Department of Marine Sciences, Faculty of Fisheries and Marine Science University of Pattimura, Rupiasa James ,   Maritime and Marine Science Centre of Excellence of Pattimura University
Published: January 2025

Studies of coral reef diseases in Indonesia, particularly in
Ambon waters, Maluku, have been rare. The objectives of
this study were to identify the types of diseases in this area,
the prevalence and abundance of coral diseases at different
depths at different sites. This study was conducted at four
sampling sites; Liang, Morela, Kaitetu and Erie with their
specific situations, at two different depths which are 3 and
10 metres, parallel to the shoreline. Each site was surveyed
twice using the belt transect method over an area of 250 m2
for three months. The type of disease was identified using
the Coral Disease Handbook and Decision Tree Table with
the help of photographs taken with underwater camera.
The result shows four types of diseases, they were black
band disease, white syndrome disease, white band disease
and white plague disease. The prevalence and abundance
of coral diseases were not significantly different between
depths (T-test, p0.05). Sampling site Erie had the highest
prevalence of diseases due to the environmental pressure
that is having a lot of domestic waste.
Exposure To Subthreshold Dose Of Uvr-B Does Not Induce Increase In Caspase 3 Mrna Expression In The Rat Lens In Vivo Within First 24 Hours.
Authors: Galichanin Konstantin , Yu Zhaohua ,   Gullstrand lab, Section of Ophthalmology, Dept. of Surgical sciences, Uppsala University, Uppsala, Sweden
Published: January 2025

Purposes: The aim of this study is to investigate the time
evolution of caspase 3 mRNA expression within first 24
hours in the rat lens after in vivo exposure to subthreshold
dose of UVR-B.
Methods:Twelve six-week-old female albino SpragueDawley rats were exposed to subthreshold dose (1 kJ/m2)
of UVR-B unilaterally and sacrificed at 1, 8, 16 and 24 hours
after exposure. Lenses were enucleated and caspase 3 mRNA
expression was detected by qRT-PCR. The time evolution of
caspase 3 mRNA expression was then plotted as a function
of mean ratios in caspase 3 mRNA expression between
exposed and contralateral nonexposed lenses.
Results: There is no difference in mean ratios in caspase 3
mRNA expression between exposed and nonexposed lenses
in all four postexposure groups.
Conclusions: Exposure to subthreshold dose of UVR-B does
not induce increase in caspase 3 mRNA expression in the rat
lens in vivo within first 24 hours.
Translational relevance: Preclinical animal model study of
ultraviolet radiation B cataract might lead to the development
of new non-surgical therapy of cataract.
Meta Analysis: The Effect of STAD Type Cooperative Learning Model on Students' Mathematics Learning Outcomes
Authors: Arifah Dewi Nur , Katminingsih Yuni , Widodo Suryo
Published: January 2025

Several studies have shown that the STAD cooperative learning model has an effect on improving students' mathematics learning outcomes. However, the results of these studies still vary. Therefore, it is necessary to conduct a meta-analysis to find out comprehensively. The purpose of this study was to determine the effect of the STAD type cooperative learning model on students' mathematics learning outcomes, in addition, this study also aimed to see the differences in the effect of the STAD type cooperative learning model in the education level.This study used the meta-analysis method. The method is a synthesis of quantitative research that uses numbers and statistics from various research results to measure and separate information from the resulting data so as to improve completeness. This meta-analysis was conducted using the PRISMA protocol. The results stated that the STAD type cooperative learning model had an effect on student learning outcomes with an overall effect size of 1.38 so that it could be said to be in the very large effect category. Meanwhile, when viewed from the level of education, the largest average effect size is the high school level but there is no significant difference in influence. Based on the results of this study, the STAD type cooperative learning model can be used as a recommendation as a learning model that can be applied at all levels of elementary, junior high and high school.

Keywords: Cooperative, STAD, Math Learning Outcomes, and Meta Analysis
Analysis of Operational Risk Management in Logistic Companies: A Case Study of PT Sugiarto Jaya Mandiri Transport Bogor
Authors: Rahmah Tesya Luthfia , Novianti Tanti , Mulyati Heti
Published: January 2025

This study aims to analyze operational risk management at PT Sugiarto Jaya Mandiri Transport, a logistics company that focuses on transporting heavy equipment. Using an approach based on SNI ISO 31000:2018, this study identifies the operational risks faced, analyzes the level of risk based on its probability and impact, and formulates risk mitigation strategies. Data was collected through in-depth interviews, surveys, questionnaires, and document reviews. The Failure Modes and Effect Analysis (FMEA) method is used to analyze and prioritize risks.The results of the study showed that there were 19 operational risks identified, including process, HR, system, business, and incidental aspects. Key risks include delivery delays, fleet breakdowns, accidents, and operational system mismatches. Recommended mitigation strategies include improving operational processes, strengthening oversight, and implementing ISO 31000-based risk procedures. This research makes an important contribution to the management of operational risks in the logistics sector, with practical implications to improve efficiency, reduce losses, and ensure business sustainability.

Keywords: Failure Modes and Effect Analysis (FMEA), logistics, operational risk management, SNI ISO 31000:2018.
The Relationship of the Consumption of Mother's Blood Supply Tablets During Pregnancy and the Incidence of Stunting in Toddler
Authors: Batubara Frisca Ronauli , Lumbantobing Romauli , Firza Vinata Theofany
Published: January 2025

This research aimed to determine the relationship between maternal consumption of blood supplement tablets during pregnancy and the incidence of stunting in toddlers at the Parungkuda Health Center UPTD in 2024. The type of research used was analytical research with a cross sectional approach. Based on the results of Univariate research, it was found that 16 children experienced stunting (18%) and 73 children did not experience stunting (82%). There were 48 male children (53.9%) and 41 female children (46.1%). Among the mothers at the posyandu who were the most respondents in filling out the questionnaire were Jayanti posyandu, 11 mothers (12.4%) and the fewest were Melati 3 posyandu, Melati 6 posyandu and Melati 9 posyandu, there were 6 mothers (6.7%). It was found that 37 mothers (41.6%) had the highest level of education, while 6 mothers had at least a Diploma or above education (6.7%). There were 42 mothers (47.2%) who married under the age of 21 years. 47 mothers married when they were >21 years old (52.8). It was found that 67 mothers (75.3%) were compliant in consuming TTD. And 22 mothers were disobedient in consuming TTD (24.7). It is known that there are 78 mothers (87.6%) who have a good attitude towards consuming TTD and 11 mothers (12.4%) who have a bad attitude towards consuming TTD. In the bivariate results, there was a significant relationship between maternal TTD consumption during pregnancy and the incidence of stunting in toddlers, p=0.000 (p=<0.05). These results show that there is a significant relationship between the readiness of mothers to consume TTD during pregnancy and the incidence of stunting in toddlers at the Parungkuda Community Health Center UPTD in 2024 with a result of p=0.000 (0.05).

Keywords: pregnant women, macro micro nutrients, iron, TTD, stunting
From Analog to Digital: Role of Intraoral Scanners in Dentistry - A Review Article
Authors: . Kirti , Koul Rudhra , . Kirti , Kaur Jasdeep , Mahajan Arjun
Published: January 2025

Intraoral scanners (IOS) have revolutionized the field of dentistry, offering a cutting-edge alternative to traditional impression methods. These innovative devices enable dentists to capture highly accurate digital impressions of a patient's teeth and surrounding tissues, streamlining the treatment process and enhancing patient care. Recent years have witnessed notable IOS technology advancements, characterized by hardware innovations and software breakthroughs. These developments improved intraoral scanning efficiency and accuracy in computer-aided design and computer-aided manufacturing (CAD-CAM), which remains IOS’s most common use case.

Keywords: Intraoral scanners (IOS), computer-aided design and computer-aided manufacturing (CAD-CAM), Dentistry.
A Comprehensive Review of Nanoparticle Characterization Techniques
Authors: Sreelatha K. , AnandaKumar C. S. , Saraswathi M. , Anusha P. , Rose N. Madhuri , Bhargava Deepthi
Published: January 2025

Synthesized nanoparticles have a significant impact on many aspects of daily life, driving innovations in a wide range of industries, from healthcare to electronics and energy. Their unique properties, including a high surface-area-to-volume ratio, enhanced chemical reactivity, and size-dependent characteristics, make them ideal for a variety of applications. Synthesized nanoparticles play an increasingly important role in our daily lives, transforming industries and improving the quality of life in many ways. From healthcare and environmental sustainability to electronics and food safety, the unique properties of nanoparticles offer solutions that are more efficient, sustainable, and effective. As nanotechnology continues to evolve, the potential for nanoparticles to shape our future and revolutionize everyday products is immense.

Keywords: Characterization of Synthesized Nanoparticles- Need, Methods
Product Business Development Strategy of ABC Ltd. (Case Study: Point of Sales Product Development Company)
Authors: Luthfi Ihsan Muafa , Indrawan Raden Dikky , Djohar Setiadi
Published: January 2025

This study investigates the strategic positioning of ABC Ltd. in the competitive Point of Sale (POS) industry, employing tools such as External Factor Evaluation (EFE), Internal Factor Evaluation (IFE), SWOT analysis, and Analytical Hierarchy Process (AHP). Results indicate that ABC Ltd. demonstrates strong capabilities in leveraging external opportunities, achieving an EFE score of 3.46, and internal strengths, reflected in an IFE score of 3.34. Key opportunities include government support for digitalization and the growth of Indonesia’s digital economy, while primary strengths lie in active sales strategies and innovation-driven product development. A comprehensive SWOT analysis identified strategic options, and AHP prioritized an aggressive strategy (weight: 0.389) focusing on technological innovation and SME market penetration. Secondary strategies emphasize operational improvements and risk mitigation. The study concludes that ABC Ltd. is well-positioned to sustain growth by aligning its strengths with market opportunities while addressing weaknesses and mitigating threats.

Keywords: SWOT analysis, External Factor Evaluation (EFE), Internal Factor Evaluation (IFE), Analytical Hierarchy Process (AHP), Strategic Management, Technological Innovation
Application of Interactive Multimedia Assisted by Wordwall to Increase Learning Motivation and Student Learning Outcomes in Indonesian Language Learning
Authors: Oktaviana Ina , Sukasih Sri , Aeni Kurotul
Published: January 2025

This research was conducted to describe the increase in student learning outcomes, describe the increase in learning motivation in Indonesian language learning and also describe the differences in results between children who learn by applying interactive multimedia with the help of wordwalls compared to children who learn with conventional media. The mixed method for testing student learning outcomes is carried out using normality tests, homogeneity and difference tests (t tests). Student learning outcomes in learning Indonesian using interactive multimedia with the help of wordwall are higher than those of children who learn with conventional media. It is hoped that teachers can apply and try more varied interactive multimedia, with the aim that student learning outcomes and character can be improved.

Keywords: Interactive multimedia, Wordwall, Motivation to learn, Learning outcomes Indonesian
Integrating AI-Driven Tax Technology into Business Strategy
Authors: Aladebumoye Tolulope
Published: January 2025

The integration of Artificial Intelligence (AI) into tax technology presents transformative potential for enhancing business strategies by significantly improving efficiency, accuracy, and compliance. This paper delves into these advancements and critically evaluates their strategic implications across various sectors, providing a thorough analysis of how AI-driven innovations are reshaping tax practices. It highlights the dual role of AI in not only simplifying and automating complex tax operations but also in enabling businesses to navigate the increasingly complex maze of global tax regulations more effectively. Furthermore, this exploration extends to the potential challenges that accompany the adoption of AI technologies, such as data security, privacy concerns, and the need for robust ethical frameworks to guide their use. Through a comprehensive literature review and analysis, it becomes evident that while AI-driven tax technology can dramatically enhance business operations and strategic planning, it also introduces significant challenges that require careful consideration and strategic management. The paper discusses these issues in depth, alongside proposing potential solutions that can help businesses harness the full potential of AI in their tax functions without compromising on security or ethical standards. The findings underscore the critical balance between leveraging technological advancements and addressing the associated risks, suggesting a roadmap for successful integration into business practices.

Keywords: Artificial Intelligence, Tax Technology, Business Strategy, Tax Compliance, Data Security.
Indian Knowledge System and Globalization:
An Intensive Study
Authors: Khare Priya Soni , Kumar Jitendra
Published: January 2025

This study examines the relevance of the Indian Knowledge System (IKS) in the context of globalization, analysing how traditional Indian wisdom can contribute to modern global challenges such as sustainability, health, and education. It highlights the role of IKS in providing alternative solutions to pressing global issues, promoting holistic well-being, and addressing ethical concerns related to globalization. Through a comprehensive review of historical, philosophical, and contemporary aspects of IKS, the study offers insights into its significance in shaping a more balanced and harmonious global future.

Keywords: Indian Knowledge System, Globalization, Sustainability, Traditional Wisdom, Holistic Health, Education, Cultural Integration
Evaluation and Monitoring of the Aerial Woody Plant Biomass of the Classified Forests of Forest Guinea on the Basis of Satellite Imagery Data
Authors: Lamarana BAH Amadou , CAMARA Tidiane Alpha , CAMARA Yacouba
Published: January 2025

Guinea has a large block of tropical rainforests that reflect a high carbon dioxide (CO2) sequestration potential. Accurately determining the quantity and distribution of carbon in these forests will make it possible to assess CO2 emissions associated with deforestation and degradation. The objective of this research is to explore the contribution of remote sensing to the estimation of plant biomass in the classified forests of Forest Guinea (Guinea). The “Random Forest” method allowed us to predict the aboveground biomass by integrating the biomass samples from the study area. The results of the carbon stock estimates (in tonnes) for the three (3) Classified Forests and two (2) Biosphere Reserves of Forest Guinea were compared to the studies of Nasi et al. (2011) and Gibbs et al. (2014). Generally speaking, our methodology made it possible to arrive at estimates higher than those of Gibbs et al. (2014) and lower than those of Nasi et al. (2011). These results obtained from MODIS data could be considered as average values of the biomass gradient and carbon stock estimates for these different Forests and Reserves in the said area. However, we note the existence of two (2) Areas where we obtained higher values compared to the aforementioned studies, namely the Ziama classified forest (17.58 - 544.12 t/ha and 60.53 teCO2/ha) and the Mount Nimba Biosphere Reserve (25.39 - 300.44 t/ha and 42.18 teCO2/ha).

Keywords: Assessment; Monitoring; Biomass; Woody Plant; MODIS; REDD; Forest
Efficacy of Core Muscle Strengthening Exercises in Postpartum Chronic Low Back Pain - A Case Study
Authors: KH Bharath , Dharani Mavuru , N Rakshitha.
Published: January 2025

Low back pain is a global health concern affecting approximately 80% of individuals at some point ranking as the leading cause of worldwide disability. This study investigates the efficacy of core muscle strengthening exercises in postpartum chronic low back pain. This study has been done on a 31 year old female who complained of low back pain since 2 years after her delivery. The patient was given 15 days of core muscle strengthening exercises and moist heat. After 15 days of treatment, the pain has been reduced from 8 to 4 and has also improved her lifestyle than before. This study concluded that core muscle strengthening exercises was found to be moderately effective in chronic postpartum low back pain.

Keywords: Low Back Pain, Prolapsed Intervertebral Disc, Numerical Pain Rating Scale, Straight Leg Raise Test, Oswestry Disability Index.
Человеческий капитал руководителей корпораций: социологическое измерение
Authors: Дерюгин П. П. , Камышина Е. А. , Лебединцева Л. А. , Глухих В. А. , Милецкий В. П.
Published: January 2025

Учебное пособие содержит краткое изложение основных теоретических и методических вопросов по моделированию процесса исследования человеческого капитала руководителей. Предназначено для студентов и аспирантов, изучающих проблемы социологии и социологии управления.
Words across borders: kyrgyz poetry in language and learning
Authors: Бакирова А. А. , Байгобылова Г. А. , Бектурова А. А.
Published: January 2025

Пособие представляет собой сборник переводов стихотворений женщин-авторов Кыргызстана с кыргызского на английский язык, отражающие богатый культурный смысл кыргызской поэзии. В него включены упражнения и задания для изучения культурных и языковых аспектов, помогающие понять нюансы перевода и сложности передачи смысла оригинала. Также предусмотрены вопросы для обсуждения и письменные задания, стимулирующие критическое мышление. Пособие предназначено для студентов, преподавателей, переводчиков и любителей поэзии, а также для курсов по переводу и литературе.
Comparison Between Cox and Weibull Survival Models in Estimating the Determinants of Divorce in Rivers State, Nigeria
Authors: I. Okenwe, , I. D. Essi, , A. I. Wegbom,
Published: January 2025

This study examined the comparison between Cox and Weibull survival models in estimating the determinants of divorce in Rivers State, Nigeria. Data consisting of demographic, socio-economic and treatment related variables were collected from Judiciary High court for a period of 10 years for the analysis. The factors estimated were age at marriage of husband and wife, presence of children, duration of marriage, employment status of husband and wife, educational level of husband and wife, number of counselling sessions and court sittings attended. Cox proportional Hazard (Semi-parametric) and Weibull (Parametric) regression models were compared for a better fit in estimating the determinants of the risk of divorce among couples, using the Akaike Information Criterion (AIC). The result showed that Cox proportional hazards regression model performed better than Weibull regression model with a difference of 44.5 AIC value lower than that of the Weibull model. Hence, Cox PH model revealed that, of all the factors, the estimated employment status of husband, presence of children and duration of marriage had significant effect on the risk of divorce. Specifically, employment status of husband and duration of marriage reduced the risk of statutory marriage divorce by 3% and 41% respectively, while presence of children in statutory marriage increased the risk of divorce by 72%. The study thereby recommended among others that the husband, who is the head of the family, should strive, struggle, engage and explore legitimate and genuine jobs or businesses to be able to provide the immediate needs of his family, because the marriage of a jobless and idle husband is always at the risk of divorce.
Psychological Safety in Saudi Arabian Healthcare: A Scoping Review
Authors: Ali Yumna , Alqurashi Roaya , Asfahani Ahmed M. , Leonard Mark , John Catherine Elisa , Kotera Yasuhiro
Published: January 2025

Background: Psychological safety arises from the knowledge that one will not be penalised for speaking one’s mind, sharing concerns, or admitting mistakes. There is a dearth of studies in the Saudi Arabian context on the subject of mindfulness-based interventions to improve psychological safety in the workplace.Objectives: This study aims to investigate psychological safety in the Saudi Arabian healthcare sector, with the goal of promoting mindfulness-based interventions for healthcare workers. Presently, there are no formal training programs in Saudi Arabia for the healthcare workforce; essentially, the concept of mindfulness-based organisational education has yet to reach the attention of human resource managers in this sector. Our aim, therefore, is to raise awareness of the potential for novel intervention programs to improve psychological safety.Methods: The review follows the Arksey and O'Malley (2005) method, using the Preferred Reporting Items for Systematic Reviews. The aim of a scoping review is to detect potential research gaps. Presently, mindfulness-based programs relating to psychological safety are under-researched in the Saudi Arabian context, and a scoping review is a preliminary requirement before a formal systematic review is conducted.Results: Our findings indicate that healthcare workers do perceive barriers to psychological safety in the workplace, suggesting a need for training interventions that may help improve this situation.Conclusion: Saudi Arabian healthcare settings require further interventions, in line with Saudi Vision 2030, to improve workplace effectiveness and increase psychological safety among healthcare workers.
From Citizen Ideology to Netizen Ideology: The Legal Culture of Digitizing Pancasila in Realizing Politeness on Social Media
Authors: Indrayani Kiki , Sulaksono S. , Tamsil T. , Prasetio Dicky Eko
Published: January 2025

This study aims to analyze the reconstruction of Pancasila ideology within the virtual space: from citizen ideology to netizen ideology, and the cultural orientation of digital Pancasila in fostering civility in Indonesian social media. This research is a socio-legal study that emphasizes a literature review and qualitative analysis. The findings underscore that a reconstruction of understanding and education on Pancasila is necessary to ensure its application aligns with contemporary developments. The cultural orientation of digital Pancasila in promoting social media civility can be achieved through digital Pancasila education, which produces influencers among Indonesian netizens committed to implementing Pancasila values on social media, and through the establishment of a Pancasila digital society network.
The Role of Constitutional Law in Shaping A Democratic Rule of Law in Indonesia
Authors: Cibu Andi
Published: January 2025

The history of the Indonesian government clearly stems from its legal history, especially Constitutional Law, which plays an important role in the structure of government. This research aims to find out the history of Constitutional Law and the role it plays in the formation of the government system that has developed to date. To achieve this goal, the research method used in this research is normative juridical, or library research. Constitutional Law has many important roles, such as resolving disputes between the government and citizens, mediating or mediating to resolve problems between the government and society, and teaching the Indonesian government to adapt to new challenges and opportunities.
Critical Analysis of Anti-Slapp Regulations in The Field of Criminal Law in Indonesia
Authors: Ahmad Gelar Ali
Published: January 2025

This study examines the issue of SLAPP (Strategic Lawsuit Against Public Participation) and the appropriate Anti-SLAPP legal protections for environmental activists in Indonesia. It highlights how SLAPP serves as a tool for corporations to intimidate and silence environmental activists who oppose practices detrimental to society and the environment, particularly those resulting from the exploitation of natural resources. This study critically analyzes the existing Anti-SLAPP regulations in Indonesia, particularly within the context of criminal law, as outlined in various regulations. The study identifies significant shortcomings in these regulations, such as the lack of clear definitions of environmental activism, bureaucratic obstacles in seeking protection, and insufficient coverage throughout the entire criminal process. The results indicate that while legal protection for environmental activists is in place, it remains partial and inadequate, necessitating a more integrated and robust regulatory framework to better protect the rights and activities of environmental activists. This study offers suggestions for harmonizing Anti-SLAPP regulations across relevant legal institutions to ensure consistent and reliable protection for environmental activists.
A Juridical Study of the Death Penalty from a Human Rights Perspective
Authors: Arifullah A.
Published: January 2025

This research aims to explore the legal and human rights implications of capital punishment, particularly in relation to the right to life as enshrined in international human rights law. The study critically examines the compatibility of the death penalty with contemporary human rights principles, focusing on its application across different legal systems. A qualitative research methodology, utilizing a systematic literature review, was employed to analyze existing scholarly works, legal documents, human rights reports, and case law related to the death penalty. The research identifies key themes such as the ethical concerns surrounding the irreversible nature of capital punishment, its lack of deterrent effect, and the racial and socioeconomic biases inherent in its application. Additionally, the study investigates the psychological and social consequences of capital punishment, including the emotional toll on both the condemned individuals and society. The findings reveal that while some countries continue to justify the death penalty, a growing global trend towards abolition is evident, fueled by concerns over human rights violations and the risks of wrongful convictions. Furthermore, the research supports the argument that the death penalty is increasingly incompatible with modern human rights standards, particularly as international legal frameworks continue to evolve. This study contributes to the broader debate on capital punishment, offering insights into its ethical, legal, and social dimensions, and calls for continued advocacy for its abolition in favor of more humane forms of justice.
Risk factors for Toxoplasma gondii seropositiv- ity in buffaloes in a Mediterranean area
Authors: Cappelli Giovanna , Bosco Antonio , Martucciello Alessandra , Di Vuolo Gabriele , Vecchio Domenico , Grassi Carlo , Serrapica Maria
Published: January 2025

Toxoplasmosis is a worldwide widespread zoonotic infection caused by the intracellular protozoan Toxoplasma gondii. This infection is considered one of the most important food-borne parasitic zoonoses globally. In addition to its public health impact, toxoplasmosis also has important veterinary implications, as it causes abortions or congenital malformations with negative economic impacts. Several serological studies on toxoplasmosis in water buffaloes (Bubalus bubalis) are fragmentary, dated, consider a low number of animals compared to the present population and do not relate the epidemiological update in an area of the Mediterranean. For this reason, the objectives of this study were to define the seroprevalence of T. gondii infection in water buffaloes and to assess the risk factors associated with infection in water buffalo farms. A total of 184 dairy buffalo farms were randomly selected upon arrival of blood samples collected during state prophylaxis and analyzed with an indirect ELISA kit (ID Screen®, Indirect Toxoplasmosis Multi-Species, IDVET, France), according to the manufacturer›s instructions. The random selection of farms allowed us to consider different areas of the Campania region where the highest concentration of buffalo herds exists. For the risk assessment study, a specially designed questionnaire was administered that considered several factors (number of animals, presence of cats and rodent control measures) as well as presence of clinical signs such as abortions in adult buffaloes. Of a total of 13,649 animals analyzed, 2,693 tested positive for T. gondii (19.7%; 95% Confidence Interval [CI] = 19.7-24.6%), and out of 184 buffalo farms 179 tested positive (97.3%; 95% CI = 93.8- 98.8%). Of the T. gondii positive farms, 97% had cats on the farm and 85% did not implement rodent control measures. These findings indicate that these two risk factors are the most prevalent and need to be monitored for infection control on buffalo farms.
Gastrointestinal parasites in buffalo calves in a farming context in Colon county, Zulia state, Venezuela
Authors: Rodríguez María , Uzcátegui David , González Andrea , Fernández Steward , Sánchez Alfredo
Published: January 2025

The buffalo (Bubalus bubalis) is an animal species of great importance for producing milk and meat. Buffaloes have been considered rustic and resistant to many pathologies. However, they are susceptible to parasitic infections. Gastrointestinal parasites (GIP) decrease production, cause growth retardation and death of animals. Furthermore, buffalo calves are the most affected animals. To evaluate the prevalence (%) and mean intensity of infection of gastrointestinal parasites in buffalo calves and their association with age and sex, a non-experimental field study was carried out in the Agropecuaria Rosa Elena (a dual-purpose buffalo system) using crossbreed animals (Murrah and Mediterranean breeds). The buffalo farm is located in the municipality of Colón, Zulia, Venezuela. Eightythree out of 106 buffaloes were randomly selected, stratified by age (months): A (≤ 1 m); B (>1 ≤2 m); C (>2 ≤ 3 m); and D (> 3 ≤ 4 m), and sex. Fecal samples were taken directly from the rectum and processed by McMaster’s technique using saturated saline as flotation medium. The eggs or oocysts per gram of feces (EPG/OPG) were determined. The data was analyzed to determine the prevalence using contingency tables and Chi2; for the intensity variable, the mean of EPG and OPG was calculated, and an ANOVA and comparison of Tukey means was performed. The overall prevalence was 94%, with polyparasitism (37.8%, 32.9%, and 3.7% in two, three, and four GIP species, respectively). Therefore, it was possible to identify these parasites: strongylids (34%), Strongyloides sp. (44%); Toxocara vitulorum (37%) and Eimeria spp. (83%). In the age groups the overall prevalence was higher in C (100%), for strongylids (77.8%) and Strongyloides sp. (72.2%) in C, T. vitulorum (66.7%) in B, with significant association (p<0.05); Eimeria spp. was the most prevalent GIP in all age groups. The variation in intensity of infection of strongylids increased from A (666.7 EPG) to C (978.6 EPG); in contrast, Strongyloi-des sp. decreased with age, being higher in A (442.3 EPG). T. vitulorum increased from A (2250 EPG) to C (9225 EPG). However, these variations did not show significance (p>0.05). Eimeria spp. presented the higher mean intensity of infection in A (102243.18 OPG), with significant statistical differences (p<0.05) in all groups. No significant statistical differences were found in the prevalence and mean intensity associated with sex. It is concluded that GIP are affecting buffalo calves with a high general prevalence, being Eimeria spp, the most significant. It is also shown that the prevalence is associated with the age of the animals, which is of great importance for the design of control programs.
Pregnancy rate following an estradiol-free fixed- TAI protocol during breeding and non-breeding season in water buffaloes under tropical condi- tions
Authors: Camacho de Gutiérrez Adriana , Camacho Obdulio , Fernández Steward , González Yerixo , Gutiérrez-Añez Juan Carlos
Published: January 2025

Fixed-timed artificial insemination (FTAI) protocols combining estradiol (E2) and progesterone (P4) are commonly used in the tropics, with adequate pregnancy rates throughout the year in buffaloes. However, the application of E2 and its related esters in food-producing animals is banned in the European Union and by the FDA-USA. This study aimed to evaluate the pregnancy rate (PR) after FTAI in buffalo cows (Bubalus bubalis) treated during the breeding (September-January) and non-breeding season (February-June) using a protocol based on P4 intravaginal devices (IVD) combined with GnRH and PGF2α. The trial was performed on a commercial buffalo farm in Zulia State, Venezuela. Two hundred forty-seven buffalo cows (1-14 calvings) with a body condition score (BCS) of 3.15 ± 0.39 were selected. Cows were synchronized on a random day of the estrus cycle. To synchronize the ovulation on day 0, a dose of 10.5 μg GnRH-analog (Buserelin benzoate acetate, Gestar®) was injected intramuscularly (IM) plus the insertion of an IVD maintained for nine days [TRIU B®: 1.0 gr P4, (n=139); CIDR®: 1.38 gr P4 (n=77); or PREGNAHEAT-E®: 250 mg of medroxyprogesterone acetate (MPA), (n= 18)]. On day 9, IVD was removed, and 0.50 mg of Cloprostenol (Estrumate®, Intervet, MSD Animal Health) plus 500 IU of eCG (Folligon®, Intervet, MSD Animal Health) were given IM. On day 11, a dose of 10.5 μg GnRH-analog IM was used, and 8-12 hours later, they were artificially inseminated using frozen-thawed semen of bulls with proven fertility. The pregnancy rate (PR) was determined 30-32 days after AI by ultrasound. The data was analyzed by logistic regression through the Proc Logistic, and continuous and linear character variables were analyzed through the Proc GLM of the SAS® package. The overall PR was 52.2% (n = 129/247). Evaluation of independent variables, such as the number of calving and BCS, did not affect the PR (p>0.05). The PR was similar (p>0.05) amongst the reproductive and non-reproductive seasons [52.2%: (66/129) vs. 53.4% (63/118), respectively]. IVD-type did not affect the PR (p>0.05) [TRIU- B®: 52.6% (80/152), CIDR®: 53.3% (41/77) and PREGNAHEAT-E®: 44.4% (8/18)]. In conclusion, this FTAI protocol based on P4 and GnRH and PGF2α produced adequate pregnancy rates during breeding and non-breeding seasons. These findings suggest that GnRH could be considered to substitute E2 esters in the P4-based FTAI protocols in water buffaloes under tropical conditions.
Real-time data visualization for telecom networks and business analytics: A conceptual framework for enhanced decision-making
Authors: Anuoluwapo Collins  , Oladimeji Hamza  , Adeoluwa Eweje
Published: January 2025

In the dynamic telecom industry, real-time data visualization plays a critical role in enhancing decision-making by providing actionable insights that enable operators to respond swiftly to network performance issues, customer demands, and market trends. This paper presents a conceptual framework for real-time data visualization in telecom networks, integrated with business analytics to optimize network management and improve strategic business decisions. As telecom networks become increasingly complex with the integration of 5G, IoT, and cloud technologies, the need for advanced data visualization tools that can process and display real-time information has never been more crucial. The framework proposed in this study emphasizes the integration of real-time data streams from network infrastructure with advanced visualization techniques, including dashboards, heatmaps, and interactive graphs. By leveraging big data analytics and machine learning algorithms, telecom operators can gain deeper insights into network usage, traffic patterns, and service performance, facilitating proactive management of network resources and customer experience. Furthermore, this framework aligns network performance monitoring with broader business analytics, allowing decision-makers to correlate operational data with financial metrics, customer satisfaction, and market positioning. Key components of the framework include data collection from diverse network sources, data transformation for visualization, and the use of predictive analytics to forecast trends and identify potential issues before they escalate. Real-time data visualization enables telecom managers to monitor KPIs, optimize resource allocation, and quickly address bottlenecks or service disruptions. The paper also explores the benefits of integrating data visualization into telecom business strategies, such as enhancing customer engagement, improving operational efficiency, and driving innovation. Ultimately, this conceptual framework offers a comprehensive approach to utilizing real-time data visualization and business analytics in telecom networks, fostering better decision-making, reducing operational risks, and enhancing overall business performance.
Efficacy and safety of C-arm computed tomography-guided microwave ablation with percutaneous osteoplasty for flat bone metastases
Authors: Lin Zhi-Peng , Zou Xu-Gong , Huang Da-Bei , Chen Yuan , Lin Jia-Wen , Li Xiao-Qun , Zhang Jian
Published: January 2025

BACKGROUND

Flat bone metastases are common in patients with advanced cancers, often resulting in severe pain, limited mobility, and reduced quality of life (QOL). Traditional treatment options, such as radiotherapy or systemic therapies, often fail to provide sufficient pain relief or improve functional outcomes in these patients. Microwave ablation (MWA) offers advantages, such as shorter procedure times and larger ablation zones, while percutaneous osteoplasty (PO) enhances bone stability and prevents pathological fractures. Despite these benefits, the combination of these techniques for treating flat bone metastases remains underexplored.

AIM

To evaluate the efficacy and safety of C-arm computed tomography (CT)-guided MWA combined with PO for managing painful flat bone metastases, focusing on pain relief, functional improvement, and QOL enhancement.

METHODS

A total of 45 patients with refractory moderate-to-severe pain resulting from flat bone metastases who underwent C-arm CT-guided MWA combined with PO between January 2015 and January 2021 were included. The efficacy of the procedure was assessed by changes in the visual analog scale (VAS), Oswestry disability index (ODI), and QOL, as well as the occurrence of complications. Tumor response was evaluated using RECIST v1.1 and mRECIST criteria, with overall response rate (ORR) and disease control rate (DCR) as the primary endpoints.

RESULTS

No serious complications were observed in any of the patients. A significant reduction in VAS and ODI was noted at 1 week, 1 month, and 3 months post-procedure. A marked improvement in QOL was observed at all follow-up points. Bone cement extravasation was observed in 10 patients; however, none exhibited significant clinical symptoms. Based on RECIST v1.1, the ORR was 26.7% and the DCR was 88.9%. The mRECIST evaluation revealed a higher ORR of 51.1% and DCR of 88.9%.

CONCLUSION

C-arm CT-guided MWA with PO provides a dependable and effective strategy for managing flat bone metastases. It demonstrates significant pain relief, improved functional outcomes, and enhanced QOL. This treatment combination also shows promising tumor response rates with a low complication profile.
Furmonertinib re-challenge for epidermal growth factor receptor-mutant lung adenocarcinoma after osimertinib-induced interstitial lung disease: A case report
Authors: Wei Fei-Fei , Zhang Jing , Jia Zhe , Yao Zhi-Chao , Chen Chun-Qiao
Published: January 2025

BACKGROUND

Most non-small cell lung cancer patients have epidermal growth factor receptor (EGFR) activating mutations, such as exon 19 deletion and exon 21 replacement mutations. Osimertinib is a third-generation EGFR-tyrosine kinase inhibitors approved for the treatment of lung cancer patients carrying EGFR activating mutations. Osimertinib-induced interstitial lung disease (ILD) is a rare and potentially fatal pulmonary toxic manifestation of drug therapy. At present, there is no international consensus on the risks and treatment of the osimertinib-induced ILD.

CASE SUMMARY

We report a case of a 56-year-old woman who was diagnosed with lung adenocarcinoma with lung hilum, mediastinal lymph nodes and brain metastases (T4N3M1c stage IVB). The patient received targeted treatment with osimertinib after radiotherapy and chemotherapy. But she developed ILD after osimertinib treatment. Following active symptomatic treatment and hormone treatment, the lung injury alleviated. The patient was retreated with furmonertinib combined with prednisone and did not experience ILD again. So far, she has survived for 14 months without disease progression.

CONCLUSION

Retreatment with furmonertinib under prednisone could be considered as an effective therapeutic option after risk-benefit assessment for EGFR-mutant lung adenocarcinoma patients.
Overall survival with frontline vs subsequent anti-epidermal growth factor receptor therapies in unresectable, RAS/BRAF wild-type, left-sided metastatic colorectal cancer
Authors: Pakvisal Nussara , Goldberg Richard M , Sathitruangsak Chirawadee , Silaphong Witthaya , Faengmon Satawat , Teeyapun Nattaya , Teerapakpinyo Chinachote , Tanasanvimon Suebpong
Published: January 2025

BACKGROUND

The combination of anti-epidermal growth factor receptor (EGFR) therapy and chemotherapy is currently a preferred first-line treatment for patients with unresectable, RAS and BRAF wild-type, left-sided metastatic colorectal cancer (mCRC). Several studies have also demonstrated the benefit of anti-EGFR therapy in subsequent line settings for this patient population. However, direct evidence comparing the effectiveness of frontline vs subsequent anti-EGFR therapy remains limited, leaving a crucial gap in guiding optimal treatment strategies.

AIM

To compare overall survival (OS) between frontline and subsequent anti-EGFR treatment in patients with unresectable, RAS and BRAF wild-type, left-sided mCRC.

METHODS

We retrospectively reviewed the medical records of mCRC patients treated at The King Chulalongkorn Memorial Hospital and Songklanagarind Hospital, Thailand, between January 2013 and April 2023. Patients were classified into two groups based on the sequence of their anti-EGFR treatment. The primary endpoint was OS.

RESULTS

Among 222 patients with a median follow-up of 29 months, no significant difference in OS was observed between the frontline and subsequent-line groups (HR 1.03, 95%CI: 0.73-1.46, P = 0.878). The median OS was 35.53 months (95%CI: 26.59-44.47) for the frontline group and 31.60 months (95%CI: 27.83-35.37) for the subsequent-line group. In the subsequent-line group, 71 patients (32.4%) who ultimately never received anti-EGFR therapy had a significantly worse median OS of 19.70 months (95%CI: 12.87-26.53).

CONCLUSION

Frontline and subsequent-line anti-EGFR treatments provide comparable OS in unresectable, RAS/BRAF wild-type, left-sided mCRC patients, but early exposure is vital for those unlikely to receive subsequent therapy.
Residual gastric cancer with a mixed small cell neuroendocrine and keratinizing squamous cell carcinoma: A case report
Authors: Wang Tian , Cheng Yang , Hu Fan , Wang Qiang
Published: January 2025

BACKGROUND

Despite advancements in early detection and treatment, the prognosis and histological types for residual gastric cancer (GC) remains poor.

CASE SUMMARY

This case report presents a rare occurrence of residual GC featuring a combination of small cell neuroendocrine carcinoma (SCNEC) and squamous cell carcinoma (SCC) in a 60-year-old male patient. The patient, with a history of Billroth II gastrectomy for duodenal ulcer bleeding, presented with gastrointestinal bleeding. Preoperative computed tomography and positron emission tomography-computed tomography indicated adenocarcinoma with tumor and abdominal lymph node metastasis. The patient underwent laparoscopic total gastrectomy and lymph node dissection for residual GC. Histological examination of the resected tumor confirmed the presence of both SCNEC and SCC. Postoperatively, the patient underwent adjuvant chemotherapy four times. Two years later, the patient was found to occur esophageal cancer and was performed a small bowel stoma and radical esophagectomy.

CONCLUSION

In this case report, we detail a rare instance of residual GC with mixed SCNEC and SCC, emphasizing the complexity of diagnosis and treatment, and the need for ongoing research.
Predicting preoperative lymph node metastasis in esophageal cancer: Advancement and challenges
Authors: Le Xing-Yan , Feng Jun-Bang , Guo Yi , Zhou Yue-Qin , Li Chuan-Ming
Published: January 2025

Accurate preoperative prediction of lymph node metastasis is crucial for developing clinical management strategies for patients with esophageal cancer. In this letter, we present our insights and opinions on a new nomogram proposed by Xu et al . Although this research has great potential, there are still concerns regarding the small sample size, limited consideration of biological complexity, subjective image segmentation, incomplete image feature extraction and statistical analyses. Furthermore, we discuss how to achieve more robust and accurate predictive performance in future research.