bluuebunny/crossref_metadata_2025 huggingface dataset:
Using a neural network to identify diseased potato plants
Authors: Aksenov A. G. , Teterin V. S. , Ovchinnikov A. Yu. , Panferov N. S. , Pekhnov S. A.
Published: October 2022

Relevance. In order to obtain high-quality seed material, seed farms should pay great attention to crop cultivation technologies. At the same time, an important role is played by the implementation of such breeding measure as phyto-cleaning of breeding and seed plots, in order to identify and eliminate infected plants. However, it is worth noting the fact that the implementation of such measure requires the presence of highly qualified specialists capable of detecting plant diseases at early stages. However, currently there is a shortage of such employees in agriculture, and therefore the development of innovative digital technologies aimed at detecting infected plants is an urgent task. Currently, machine vision and neural network technologies designed to solve such problems are actively developing.Methods. As part of the research, existing machine vision technologies were analyzed, as well as developed machine learning technologies. Then, based on the analysis, a software package based on a convolutional neural network was developed. During the training and testing of the neural network, framing technologies, affine transformation methods, information and logical analysis of the initial information were used.Results. To determine the quality of the software package for the identification of diseased potato plants, a series of tests was conducted. During the research, the accuracy with which the distribution of plants to a particular group was carried out was evaluated. The analysis of the results showed that the chosen neural network design successfully coped with the experimental task. At the same time, for the further development of this direction, it is necessary to create an extensive information base on potato diseases. That will allow in the future to develop a software and hardware complex for the analysis of potato plantings and the identification of infected plants in real time.
The concept of evelopment of digitalization of complex land reclamation
Authors: Yurchenko I. F.
Published: October 2022

Relevance. The growing population and fierce competition in the global and domestic markets for food products have determined the priority of the digitalization of the reclamation water management complex. The purpose of the work is to highlight the fundamental approaches and promising areas of digitalization of integrated land reclamation.Methods. The research was based on a systematic approach to the digitalization of land reclamation activities. The results of the analysis of practical experience and the integration of publications of domestic and foreign scientists are supplemented with indicators of heuristic forecasts for the effectiveness of the modernization of production processes and land reclamation enterprises, materials for processing statistical data on the use of digital solutions in agricultural production using instrumental methods and experimental calculations.Results. The analysis of the current state of digitalization of the sphere of land reclamation activities of the domestic agro-industrial complex has been carried out. The need for modernization of land reclamation facilities based on digital solutions for the technological processes of their design, construction and operation has been identified. The goals and objectives of digitalization of measures, engineering systems and land reclamation facilities are formulated. Promising directions of digital solutions for land reclamation processes based on a platform approach are presented. The structure of the “Digital Reclamation” platform includes functional modules: "Efficient Reclamation and Water Management Complex", "Intellectual Reclamation System", "Smart Reclaimable Field", "Safe Reclamation", "Competitive Enterprise" and "Professional Reclamation", which integrate the entire scope of knowledge, information and data in the field of land reclamation activities, necessary for decision-making and implementation of control actions. The basic tools for the creation, construction and operation of the software and technological complex for the digitalization of the crop production system of reclaimed lands have been determined. The area of expected results of the introduction of digital solutions into the practice of the reclamation sector of the agro-industrial complex has been highlighted. It should be noted that the upcoming global digitalization of land reclamation is inevitable. In the end, those enterprises will win, whose managers understand this earlier, and will begin to introduce digital systems not only within individual technological processes, but also in a complex way.
Dynamics of reproductive qualities of cows depending on the productive longevity
Authors: Kharlap S. Yu. , Rebezov M. B. , Gritsenko S. A. , Safronov S. L. , Bobyleva I. V. , Zhuravel V. V.
Published: October 2022

The Ural type of the domestic black-and-white mottled breed features high productivity rates, good suitability for industrial milking technology, but the duration of its productive longevity is 2.4–2.6 lactations only, although in herds there are cows with productive longevity up to 10 lactations. The decline in productive longevity is associated in particular with reproductive qualities. As a result of the research, it was found that the Sealing Trijun Rockit cows proved to be the most resistant to their long use within the conditions of dairy farms for industrial milk production of pedigree reproducers; their productive longevity was 4.0 lactation. In other lines the productive longevity ranged from 1.8 (Pabst Governor line) to 2.5 (Montvic Chieftain line) lactations. A low fertility rate (less than 0.95) proves the existence of reproduction problems in the herd. Modern Holsteinized black-and-white mottled cattle bred in the Sverdlovsk region has high breeding qualities. The potential of their use is quite high and, despite certain reproduction problems, they are able to produce for a long time in the ecological and forage conditions of their breeding zone.
Production of Bacterial Cellulose Based Bio Nonwoven/ Nonwoven Composites for Medical Textile Applications
Authors: KILINÇ Nur , ÖZDEMİR KÜÇÜKÇAPRAZ Dicle
Published: October 2022

Bacterial cellulose (BC) is a popular biomaterial which is used in innovative research in many fields thanks to its unique properties. In this study, BC as bio nonwoven structures are produced in Kombucha culture using ‘acetobacter xylinum’ bacteria in a static culture setting. Bio nonwoven surfaces are produced with the sandwich composite model. They use 15-25-60% cotton/ viscose/ polypropylene nonwoven surface fabric and 80-20% polypropylene /viscose nonwoven surface fabric while creating bio nonwoven surfaces. Water retention, porosity, dust retention, FTIR (Fourier Transform Infrared Spectrophotometer), SEM (Scanning Electron Microscope), and TGA (Thermogravimetric Analysis) analysis of the obtained BC structures are investigated. As a result of the analysis, it is determined that the BC and BC composite structures, which have undergone hydrogen peroxide and sodium hydroxide applications, have properties that can be used for medical purposes.
Influence of Knitting Structure and Metal Wire Amount on Electromagnetic Shielding Effectiveness of Knitted Fabrics
Authors: TEZEL Serkan , KAVUŞTURAN Yasemin , VANDENBOSCH Guy A.e. , VOLSKİ Vladimir
Published: October 2022

The aim of this study is to investigate the influence of knitting structure and metal wire amount on the electromagnetic shielding effectiveness (EMSE) of knitted fabrics comparatively. Single jersey, single pique, weft locknit, and cross miss fabrics involving stainless steel or copper wires were produced on a flat knitting machine. A free space measurement technique was used for the EMSE measurements in an anechoic chamber. The variance analysis results of the EMSE values reveal that the effect of knitting structure, metal wire type, metal wire amount, and incident wave frequency is highly significant. It was observed that fabrics with tuck and miss loop structures had higher EMSE values than single jersey fabrics. It was found that single pique fabrics had higher EMSE values than single jersey fabrics that contain twice as much metal wire. It indicates that changing the knitting structure is more effective than changing the metal wire amount.
Modelo guía para realizar una movilidad estudiantil
Authors:   Universidad de Guadalajara, Hernandez Ochoa Martha María
Published: October 2022

Hay controversias con respecto a realizar o no una movilidad estudiantil, tanto a nivel medio superior como superior, que involucran intereses per- sonales, familiares, sociales, académicos, financieros, políticos, entre otros. El propósito de esta investigación es encontrar cuáles son los factores cla- ves que impactan a los estudiantes a nivel personal, familiar y profesional al momento de hacer una movilidad estudiantil a nivel superior, y qué ven- tajas y desventajas existen al momento de realizar una estadía en alguna otra universidad internacional.
Familias en guerra: valores neoliberales y la representación mediática de la invasión a Irak
Authors:   Instituto Tecnológico y de Estudios Superiores de Monterrey, Zavala Scherer Diego
Published: October 2022

El presente artículo explora las formas de representación de las familias de los soldados a través de cuestionar los mecanismos del registro de lo real, donde se utilizan los documentales de guerra como caso ejem- plar sobre el contexto de la invasión en Irak. Los dos polos teóricos de los cuales se origina esta lectura de los valores familiares como bastión del modelo bélico neoliberal estadounidense son los trabajos de Melinda Cooper (2017) y Peter Wolin (2008). El cuestionamiento del ensayo explora cómo la violencia sistémica del neoliberalismo, en un contexto de guerra, se acaba plasmando en el nivel individual o en el institucional como la familia. El interés de esta lectura hermenéutica es crear el puente entre el nivel macro (sistema neoliberal) y el nivel micro (las decisiones de los soldados y sus seres queridos).
Rethinking Auditory-Visual Synesthesia: A Case Study of Messiaen’s Synesthetic Behaviors
Authors: Lee Kuo-Ying
Published: October 2022

Current existing scholarly researches on synesthetic music diverge into contrasting directions concerning color-hearing. One type of reference focuses on the theoretical analysis of sound-color correspondences in compositions. On the contrary, in opposition to restricted colorful delineation, the other type of research examines the synesthetic ideas in music from the interdisciplinary domain of musicology through a composer’s imaginative utilization of cross-modal examples. This article takes Messiaen’s music as the synesthetic example and elaborates on the different opinions between Jonathan Bernard’s sound-color correspondences and B. M. Galeyev’s interpretation of color-hearing. Based on Mikel Dufrenne’s “Phenomenology of the Aesthetic Experience” and Messiaen’s interviews, the article explains the leading cause of the divergence between Bernard and Galeyev’s aesthetic experience. Besides, this research conducts an experiment that informally requests a non-synesthete audience to report their first impression of listening to Messiaen’s synesthetic music. By observing the averaging response time of the participants, it proposes to rethink the meaning of visual-auditory synesthesia to the audience.
Strategies to Develop Intercultural Competence of Students in a Multicultural Set Up
Authors: Pharaoh Linda , Li Jiajun
Published: October 2022

In a society that is becoming more and more globalized, and internationalization has become the new norm, intercultural competence (IC) has been proven to be a valuable skill since people are expected to behave responsibly and productively in cross-cultural interactions. The paper reviews educational intervention studies to demonstrate methods for increasing intercultural competency as well as their efficiency in a multicultural university setup. The idea of intercultural competence will be emphasized, along with the values, attitudes, skills, knowledge, and understanding that collectively make up this ability. Following this, a variety of strategies that universities can employ, such as initiatives to foster students' intercultural competence, will be examined.
ЗАВДАННЯ АУДИТУ В УМОВАХ ЛІБЕРАЛІЗАЦІЇ КОНТРОЛЮ
Authors: Корнієнко І.С.
Published: October 2022

Проаналізовано діяльність Аудиторської палати України (АПУ) та Спілки аудиторів України (САУ). На основі їх оцінки охарактеризовно економіко-правові заходи щодо вирішення поточних проблем у сфері аудиту та окреслено проблеми, що мають системний характер. Обгрунтовано актуа-льність проблематики зміни вимог щодо сплати податку та єдиного соціального внеску з боку підприє-мців, внутрішньої організації суб’єктів аудиторської діяльності та зовнішньої організації контролю аудиторської діяльності. Викладено аналіз положень Закону України «Про внесення змін до Податково-го кодексу України та інших законодавчих актів України щодо дії норм на період дії воєнного стану» від 5 березня 2022 року за № 2120-IX. Надано практичний коментар Закону України «Про внесення змін до Закону України «Про аудит фінансової звітності та аудиторську діяльність» щодо забезпечення ауди-торської діяльності на період дії воєнного стану та післявоєнного відновлення економіки».

Ключові слова: аудиторська діяльність, воєнний стан, контроль у сфері господарювання, аудит, внутрішня організація суб’єктів аудиторської діяльності.
Diástase dos retos abdominais pode levar a disfunções do assoalho pélvico?
Authors: Silveira Michele Portal da , Silva Yasmin Podlasinski da , Patrícia Furlanetto Magda
Published: October 2022

Introdução: A disfunção do assoalho pélvico é definida como qualquer desvio da função normal dos músculos do assoalho pélvico: prolapsos, incontinência, dor pélvica, disfunções sexuais. Dentre as diversas condições, a diástase dos retos abdominais é recorrente, definida como um comprometimento com a separação da linha média dos dois músculos retos abdominais ao longo da linha alba. Objetivo: Revisar a literatura dos estudos dos últimos 10 anos, a fim de responder se a diástase dos retos pode estar envolvida em alguma disfunção do assoalho pélvico. Métodos: Trata-se de uma revisão integrativa de literatura realizada através de busca em artigos científicos publicados no período compreendido entre os anos de 2011 e 2021, nas bases de dados eletrônicas Pubmed, BVS e Google Acadêmico. Resultados: Majoritariamente os estudos foram realizados em mulheres até 12 meses pós-parto e não encontraram relação das disfunções de assoalho pélvico associadas à presença de diástase dos retos abdominais. Contudo, um estudo realizado em mulheres na pré e pós-menopausa descreve que a diástase mostrou ser um fator preditivo para disfunção do assoalho pélvico. Conclusão: A variabilidade entre os protocolos aplicados dificultou a comparação entre os estudos, sendo necessários estudos com maior qualidade metodológica a fim de preencher as lacunas do conhecimento.
Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through the inhibition of autophagy
Authors: Zhang Weiguo , Yu Guopan , Zhang Hongying , Basyal Mahesh , Ly Charlie , Yuan Bin , Ruvolo Vivian , Piya Sujan , Bhattacharya Seemana , Zhang Qi , Borthakur Gautam , Battula Venkata , Konopleva Marina , Rice William G. , Andreeff Michael
Published: October 2022

Strategies to overcome resistance to FMS-like tyrosine kinase 3 (FLT3)-targeted therapy in acute myeloid leukemia (AML) are urgently needed. We identified autophagy as one of the resistance mechanisms, induced by hypoxia and the bone marrow microenvironment via activation of Bruton tyrosine kinase (BTK). Suppressing autophagy/BTK sensitized FLT3- mutated AML to FLT3 inhibitor-induced apoptosis. Furthermore, co-targeting FLT3/BTK/aurora kinases with a novel multikinase inhibitor CG-806 (luxeptinib) induced profound apoptosis in FLT3-mutated AML by co-suppressing FLT3/BTK, antagonizing autophagy, and causing leukemia cell death in FLT3-wildtype AML by aurora kinase-mediated G2/M arrest and polyploidy, in addition to FLT3 inhibition. Thus, CG-806 exerted profound anti-leukemia activity against AML regardless of FLT3 mutation status. CG-806 also significantly reduced AML burden and extended survival in an in vivo patient-derived xenograft leukemia murine model of FLT3 inhibitor-resistant FLT3-ITD/TKD double-mutant primary AML. Taken together, these findings indicate that CG-806 has a unique mechanistic action and pre-clinical activity, which is presently undergoing clinical evaluation in both FLT3 wildtype and mutant AML.
Implementación del seminario de “Seguridad del paciente y calidad asistencial en los estudiantes de obstetricia”
Authors: Alvear Cruz Diana Alejandra , Correa Auqui Luis Fabricio , Borja Cevallos Lusi Tamara
Published: October 2022

Introducción. A nivel mundial, se está implementando en el equipo sanitario laboral, una cultura de seguridad enfocada en el aumento de la calidad asistencial de sus servicios. Objetivo. Proponer la implementación de un seminario sobre Seguridad del Paciente y Calidad Asistencial para estudiantes de la Carrera de Obstetricia de una Universidad del Ecuador. Metodología. Se analizaron variables académicas de la Carrera de Obstetricia de una institución universitaria del Ecuador y posteriormente se propuso la aplicación de un seminario teórico práctico, complementario a la formación académica, relacionado con la cultura de seguridad del paciente y la calidad asistencial, que está inmersa en la atención sanitaria. Se planificaron algunos recursos didácticos para el desarrollo de competencias, tales como el aprendizaje teórico, planteamiento de problemas y resolución de problemas. La evaluación fue definida en base a indicadores. Resultados. Se identificó un diseño curricular sin contenido referente a seguridad del paciente en la Carrera de Obstetricia, en base a lo cual, se plantearon estrategias pedagógicas con la finalidad de incrementar el conocimiento de estos temas y contribuir con la disminución del riesgo que tiene el personal de salud, de provocar eventos adversos de diferentes tipos. Conclusión. Es importante que dichos temas sean impartidos desde el currículo educativo de pregrado, es decir, en las aulas universitarias, para que los futuros profesionales sean sensibilizados y logren una cultura de seguridad del paciente.
Hyperkinetic Rat Model Induced by Optogenetic Parafascicular Nucleus Stimulation
Authors: Chung Moonyoung , Park Young Seok
Published: October 2022

Objective : The parafascicular nucleus (PF) plays important roles in controlling the basal ganglia. It is not well known whether the PF affects the development of abnormal involuntary movements (AIMs). This study was aimed to find a role of the PF in development of AIMs using optogenetic methods in an animal model.Methods : Fourteen rats were underwent stereotactic operation, in which they were injected with an adeno-associated virus with channelrhodopsin (AAV2-hSyn-ChR2-mCherry) to the lateral one third of the PF. Behavior test was performed with and without optical stimulation 14 days after the injection of the virus. AIM of rat was examined using AIM score. After the behavior test, rat’s brain was carefully extracted and the section was examined using a fluorescence microscope to confirm transfection of the PF.Results : Of the 14 rats, seven rats displayed evident involuntary abnormal movements. AIM scores were increased significantly after the stimulation compared to those at baseline. In rats with AIMs, mCherry expression was prominent in the PF, while the rats without AIM lacked with the mCherry expression.Conclusion : AIMs could be reversibly induced by stimulating the PF through an optogenetic method.
Significance of Preoperative Nerve Reconstruction Using Diffusion Tensor Imaging Tractography for Facial Nerve Protection in Vestibular Schwannoma
Authors: Zhang Yuanlong , Ge Hongliang , Xu Mingxia , Mei Wenzhong
Published: October 2022

Objective : The facial nerve trace on the ipsilateral side of the vestibular schwannoma was reconstructed by diffusion tensor imaging tractography to identify the adjacent relationship between the facial nerve and the tumor, and to improve the level of intraoperative facial nerve protection.Methods : The clinical data of 30 cases of unilateral vestibular schwannoma who underwent tumor resection via retrosigmoid approach were collected between January 2019 and December 2020. All cases underwent magnetic resonance imaging examination before operation. Diffusion tensor imaging and anatomical images were used to reconstruct the facial nerve track of the affected side, so as to predict the course of the nerve and its adjacent relationship with the tumor, to compare the actual trace of the facial nerve during operation, verify the degree of coincidence, and evaluate the nerve function (House-Brackmann grade) after surgery.Results : The facial nerve of 27 out of 30 cases could be displayed by diffusion tensor imaging tractography, and the tracking rate was 90% (27/30). The intraoperative locations of facial nerve shown in 25 cases were consistent with the preoperative reconstruction results. The coincidence rate was 92.6% (25/27). The facial nerves were located on the anterior middle part of the tumor in 14 cases, anterior upper part in eight cases, anterior lower part in seven cases, and superior polar in one case. Intraoperative facial nerve anatomy was preserved in 30 cases. Among the 30 patients, total resection was performed in 28 cases and subtotal resection in two cases. The facial nerve function was evaluated 2 weeks after operation, and the results showed grade I in 12 cases, grade II in 16 cases and grade III in two cases.Conclusion : Preoperative diffusion tensor imaging tractography can clearly show the trajectory and adjacent position of the facial nerve on the side of vestibular schwannoma, which is beneficial to accurately identify and effectively protect the facial nerve during the operation, and is worthy of clinical application and promotion.
Coaching Impact on Employees and Organizational Performance in the Middle East Healthcare Industry
Authors: Saad Hany Karim
Published: October 2022

Coaching is a personal advancement and objective focused process. Achieving organizational results, improving well-being, and driving individual improvement are the main aspects of anticipated results (Rosha & Lace, 2016). This study aims to build a body of evidence on the effect of coaching on improvement on organizational accomplishment in the Middle East Healthcare industry which should support the industry leaders to adopt the coaching techniques recognizing its valuable effects on the growth of their corporations. A total of 195 respondents were involved in this study from various healthcare firms. More than 70% agree that coaching is very useful or extremely useful to achievement own goals, improves the capacity to view their strengths, and accomplish goals. The study participants confirmed that coaching challenged their thinking, improve morale, and offered new options to achieve a feeling of harmony between work, life, and relaxation. In this research, couching was found very useful to increase confidence to speak openly to managers, support achieving organizational goals, reduce the level of absence, increased productivity, and maintain high work quality. Reshaping the company’s management strategies and espousing the coaching techniques may provide improvement in the employee’s well-being and productivity leading to the development of the overall organizational performance.
METAFORA DALAM KAJIAN LINGUISTIK, SASTRA, DAN TERJEMAHAN: SEBUAH PENGANTAR
Authors: Lahay Srisna J.
Published: October 2022

Pada makalah ini penulis bertujuan untuk menunjukkan bagaimana metafora dianalisis dalam kajian linguistik, sastra, dan terjemahan. Penulis menguraikan teori dan metodologi penelitian yang digunakan untuk menganalisis metafora dalam tiga artikel ilmiah, yaitu artikel dengan judul “An Analysis on the Use of Metaphor in a News Article about Corruption” oleh Srisna J. Lahay (2020), yang meneliti penggunaan metafora dalam sebuah artikel tentang korupsi di surat kabar Republika, “Metafora dalam Ragam Bahasa Puisi (Pendekatan Teori Cognitif Linguistik)” oleh Rizka Hayati (2016), yang mengkaji penggunaan metafora dan maknanya dalam puisi karya Chairil Anwar dan Joko Pinurbo, dan “Kajian Terjemahan Metafora yang Menunjukkan Sikap dalam Buku Motivasi The Secret” oleh R. Hendrastuti, M. R. Nababan, dan Tri Wiratno (2013), yang meneliti teknik penerjemahan, kualitas terjemahan, dampak teknik terjemahan, dan alasan teknik penerjemahan memengaruhi kualitas terjemahan metafora yang menunjukkan sikap dalam buku motivasi The Secret dan terjemahannya. Dapat disimpulkan bahwa dalam tiga penelitian tersebut digunakan teori tentang metafora yang sama, yaitu Knowles dan Moon (2006) serta Lakoff dan Johnsen (2003); data yang dikumpulkan dalam ketiga penelitan itu sama, yaitu data berupa kata, frase, atau kalimat yang memuat metafora dari sumber tertulis; dan beberapa langkah penelitian yang dilakukan juga sama.
RANCANG BANGUN SISTEM INFORMASI PENGAWASAN PEMASANGAN JARINGAN LISTRIK PADA PT.PLN (Persero) AREA PALEMBANG
Authors: Sahfitri Vivi
Published: October 2022

Installation of electrical network at PT. PLN (Persero) is done by a vendor that works with the agency. Before the installation of the electricity network the vendors must fill the data first to know the responsibility of each job in the installation of electrical networks. The problem in this research is that there is no specific system used in the collection of vendors.  This research aims to design and build an application that can help PT. PLN (Persero) in supervising the electrical network installation conducted by the Vendor. The research method used is the Development research method, which is a research activity aimed at and develop or complete knowledge that is already know. The development system used is web Engineering.  The results of the research is the information system of installation control  electrical network that can help PT. PLN (Persero) in data and supervise the work that is done by the vendor so that the performance produced better and increase customer satisfaction.
Keywords: Sistem Informasi,  Pengawasan,  Web Engineering, Berbasis Web
Pilot Mental Health, Methodologies, and Findings: A Systematic Review
Authors: Ackland Corrie A. , Molesworth Brett R. C. , Grisham Jessica R. , Lovibond Peter F.
Published: October 2022

INTRODUCTION: Pilots’ mental health has received increased attention following Germanwings Flight 9525 in 2015, where the copilot intentionally crashed the aircraft into the French Alps, killing all on board. An investigation of this incident found that the pilot had a
depressive disorder.METHODS: This systematic review investigated peer reviewed studies of pilot mental health published since 1980. A total of 58 papers were identified.RESULTS: Two main methodologies have been employed: questionnaires and database record searches. Anxiety,
depression, and suicide were the most commonly investigated mental health conditions. There were almost an equal number of studies that found a higher prevalence of psychological symptoms in pilots as those that found a lower prevalence, relative to controls or the general population. Prevalence
rates were higher in studies relying solely on questionnaires than in studies employing database record searches.DISCUSSION: Prevalence estimates are closely associated with methodology, so it is difficult to determine the true rate. Factors that might account for low prevalence
estimates include under-reporting of symptoms by pilots and a reluctance to diagnose on the part of health professionals. Factors that might account for high prevalence estimates include anonymous assessment, the use of questionnaires that do not align with clinical disorders, and inconsistent
cut-off scores. It is recommended that future studies on prevalence use well-validated clinical measures, and that more research be conducted on the effects of particular disorders on job performance.Ackland CA, Molesworth BRC, Grisham JR, Lovibond PF. Pilot mental health, methodologies,
and findings: a systematic review. Aerosp Med Hum Perform. 2022; 93(9): 696–708.
Blood Glucose Alterations and Continuous Glucose Monitoring in Centrifuge-Simulated Spaceflight
Authors: Ong Karen M. , J. Rossitto Josie , Ray Kristi , A. Dufurrena Quinn , Blue Rebecca S.
Published: October 2022

INTRODUCTION: Sympathetic stimulation is known to be associated with transient alterations of blood glucose (BG) concentration; spaceflight acceleration may be similarly associated with alterations of BG, potentially posing a risk to diabetic individuals engaging in future spaceflight
activities. Despite prior studies demonstrating diabetic subjects’ tolerance to centrifuge-simulated spaceflight, data are lacking regarding blood glucose response to hypergravity. It remains unclear whether hypergravity or associated physiological response may pose a risk to diabetics.
Continuous glucose monitors (CGM) offer a means of noninvasive glucose monitoring and may be useful in spaceflight and analog environments. Here, we describe the results of continuous glucose monitoring during centrifuge-simulated spaceflight.METHODS: Subjects participated in 1–5
centrifuge-simulated spaceflight profiles (maximum +4.0 Gz, +6.0 Gx, 6.1 G resultant). Data collection included heart rate, blood pressure, electrocardiogram, continuous glucose via CGM, intermittent fingerstick BG, and postrun questionnaires regarding symptoms related
to hypergravity exposure.RESULTS: CGM data were collected from 26 subjects, including 4 diabetics. While diabetic subjects had significantly higher BG compared to nondiabetics, this was not associated with any difference in symptoms or tolerance. Transient hypergravity-associated
CGM glucose alterations did not affect tolerance of the centrifuge experience. CGM data were found to be reliable with occasional exceptions, including four instances of false critical low glucose alarms.DISCUSSION: While further study is necessary to better characterize CGM fidelity
during hypergravity and other spaceflight-related stressors, CGM may be a feasible option for spaceflight and analog settings. As in prior studies, individuals with well-controlled diabetes appear able to tolerate the accelerations anticipated for commercial spaceflight.Ong KM, Rossitto
JJ, Ray K, Dufurrena QA, Blue RS. Blood glucose alterations and continuous glucose monitoring in centrifuge-simulated spaceflight. Aerosp Med Hum Perform. 2022; 93(9):688–695.
Maturity mountain rainforest syntaxa from Sierra Maestra, Eastern Cuba
Authors: Joel-Reyes Orlando , Acosta-Cantillo Felix , Bergues-Garrido Pedro
Published: October 2022

In the Sierra Maestra the rainforests occupied mountains territories between 800 and 1 500 meters above sea level (mosl). By using the Zurich Montpellier school methodology one new order are described, Clethro cubensis- Cyrilletalia silvae with two alliances and two associations that the late and mature succesional communities are.
En la Sierra Maestra se desarrolla la pluvisilva montana entre los 800 y los 1 500 m snm con una abundante humedad ambiental. Se estudió mediante la metodología de la Escuela Zurich Montpellier a Clethro cubensis -Cyrilletalia silvae con dos alianzas que constituyen las etapas maduras y de la sucesión avanzada.
Uso de aplicaciones móviles como herramienta de apoyo tecnológico para la enseñanza con metodología steam
Authors: Martinez-Baquero Javier Eduardo , Rodríguez-Umaña Luis Alfredo
Published: October 2022

En este documento se demuestra de forma práctica como las aplicaciones móviles pueden ser consideradas como una gran herramienta, en la enseñanza de diversas áreas en básica primaria como son: matemáticas, inglés, sociales, español, entre otras. Es importante anotar cómo los docentes pueden apoyar sus procesos de enseñanza, a través del uso de dispositivos móviles, en los cuales se instalan aplicaciones sencillas de usar para los estudiantes, de fácil entendimiento y manejo. Particularmente aplicaciones como SAIA v1.0, GROBOT v1.0, STEAM MATH v1.0 y STUDENT STEAM v 1.0 que han sido diseñadas a la medida y puestas a disposición de instituciones de básica primaria, con la finalidad de apoyar sus procesos, obteniendo excelentes resultados, representando para ellos herramientas prácticas, de liviana portabilidad y de fácil manipulación, pero sobre todo son aplicaciones que permiten afianzar los conocimientos adquiridos sin la presencia del docente.

Educational mobile applications have gained strength in the teaching and learning processes, for this reason, the objective of this paper is to demonstrate how these mobile applications can be considered a great tool in teaching using steam methodology. The paper has a descriptive character, considering the way in which the different forms of learning are supported by mobile devices and are becoming new teaching models. The topics addressed, the services received, the content exposed, among others, are analyzed. The results show a positive impact after the use of the applications on the performance, motivation, attitude and interest in learning of the students in the topics developed, as well as the satisfaction of the teachers for the support of the mobile applications in their work, and how the applications allow reinforcing the knowledge acquired without the presence of the teacher.
Simulación climática de un invernadero para rosas
Authors: Osorio-Hernández Robinson , Duarte-Gualdrón Andrés Ricardo , Mahecha-Fernández Diego Camilo
Published: October 2022

La producción de rosas en Colombia se desarrolla casi en su totalidad en invernaderos ventilados en forma natural. El objetivo de este trabajo fue replicar la caracterización del microclima generado en el interior de un invernadero a través de Dinámica de Fluidos Computacional, teniendo en cuenta la evapotranspiración del cultivo. El modelo CFD utilizado fue validado mediante recopilación de datos experimentales recolectados en campo, enfocándose en las variables de temperatura y humedad relativa. Los resultados obtenidos muestran que para la condición evaluada el microclima generado varía si se tiene en cuenta la evapotranspiración en el modelo, aunque las condiciones encontradas siguen siendo óptimas para la producción de rosas.
Rose production in Colombia takes place almost entirely in naturally ventilated greenhouses. The objective of this work was to replicate the characterization of the microclimate generated inside a greenhouse through the modeling of air flows using CFD software, taking into account the evapotranspiration of the crop. The CFD-3D model used was validated by collecting experimental data collected in the field, focusing on the variables of temperature and relative humidity. The results obtained show that for the evaluated condition the generated microclimate varies if evapotranspiration is taken into account in the model, although the conditions found are still optimal for rose production
Improving Diagnosis: The Next Frontier in Hereditary Angioedema Management
Authors: Thomas Joan
Published: October 2022

Hereditary angioedema (HAE) is a rare autosomal dominant condition caused by a deficiency or dysfunction of C1 esterase inhibitor (C1-INH) that normally blocks activation of C1, the first component of the complement cascade. The condition manifests as recurrent self-limiting episodes of angioedema, without urticaria or pruritus, most commonly affecting the skin or mucosal tissues of the upper respiratory and gastrointestinal tracts.1 Symptoms are disabling and can be life-threatening when affecting the upper airways.1 Low awareness of the condition and its resemblance to other disorders typically leads to delays in diagnosis.2 Multiple mutations of the human C1-INH gene (SERPING1) have been identified, some of which cause HAE and some of which do not.1 Genetic testing alone is therefore not diagnostic of HAE and needs to be supplemented with biochemical testing and hereditary information. There are mixed opinions among clinicians and scientists on the utility of genetic testing for diagnosis of HAE. The objective of this symposium was to raise awareness of HAE and its diagnosis, along with the role of genetic testing, familial testing, and future diagnostic methods for this disorder.

Dr Stephen Jolles chaired the symposium and opened with a presentation on current diagnosis of HAE. Prof Marco Cicardi presented on biomarkers that enable earlier diagnosis of HAE; and in the final presentation, Dr Coen Maas discussed the future of HAE diagnosis. Interactive voting and question and answer sessions were used to elicit the opinions of the audience at intervals throughout the symposium, which was concluded with a general discussion session.
Do Two-Party Systems Hamper Defection from Undemocratic Candidates?
Authors: Frederiksen Kristian Vrede Skaaning
Published: October 2022

Do the electoral constraints imposed by two-party systems make citizens less likely to defect from undemocratic candidates? I employ two innovative candidate choice experiments fielded in England to answer this question. Specifically, I implement two designs manipulating the number and effective number of parties displayed between two and three, exploiting the characteristics of England's party system. Contrary to expectations, I find that Labour and Conservative identifiers do not defect more from undemocratic in-partisan candidates when they face three (effective) parties---Labour, the Conservatives, and the Liberal Democrats---rather than just the two major parties. Instead, defection from undemocratic in-partisans to the out-party drops and relocates to the Liberal Democrats even when the latter have no chance of winning. These findings highlight that having three rather than two parties does not generate more defection from undemocratic politicians---and that voters prefer defecting to the option ideologically nearest to the in-party even when chanceless.
The Russia-Ukraine War and the Maidan in Ukraine
Authors: Katchanovski Ivan
Published: October 2022

This study examines the Russia-Ukraine war in 2022 and the origins of the Russia-Ukraine conflict in the political transition during the Maidan in Ukraine in 2014. This transition of power contributed to the civil war in Donbas, Russian military interventions in Crimea and Donbas, the Russian annexation of Crimea and an international conflict between Russia and Ukraine and the West and Russia. This conflict escalated when Russia invaded Ukraine in February 2022. The research question is as follow: What is the nature of the Russia-Ukraine war and the political transition in Ukraine during the Maidan? This issue produced divergent narratives of this war and the Maidan in scholarly studies, the media, and governments. This paper uses political science theories of wars, mass protests, coups, revolutions, and regime changes and empirical analysis of various evidence to examine the nature of the Russia-Ukraine war and the political transition during the Maidan.
Aptamer-based applications for cardiovascular disease
Authors: Chen Xinyuan , Ma Yue , Xie Yuquan , Pu Jun
Published: October 2022

Cardiovascular disease (especially atherosclerosis) is a major cause of death worldwide, and novel diagnostic tools and treatments for this disease are urgently needed. Aptamers are single-stranded oligonucleotides that specifically recognize and bind to the targets by forming unique structures in vivo, enabling them to rival antibodies in cardiac applications. Chemically synthesized aptamers can be readily modified in a site-specific way, so they have been engineered in the diagnosis of cardiac diseases and anti-thrombosis therapeutics. Von Willebrand Factor plays a unique role in the formation of thrombus, and as an aptamer targeting molecule, has shown initial success in antithrombotic treatment. A combination of von Willebrand Factor and nucleic acid aptamers can effectively inhibit the progression of blood clots, presenting a positive diagnosis and therapeutic effect, as well as laying a novel theory and strategy to improve biocompatibility paclitaxel drug balloon or implanted stent in the future. This review summarizes aptamer-based applications in cardiovascular disease, including biomarker discovery and future management strategy. Although relevant applications are relatively new, the significant advancements achieved have demonstrated that aptamers can be promising agents to realize the integration of diagnosis and therapy in cardiac research.
Stem cell homing in periodontal tissue regeneration
Authors: Meng Lingxi , Wei Yige , Liang Yaxian , Hu Qin , Xie Huixu
Published: October 2022

The destruction of periodontal tissue is a crucial problem faced by oral diseases, such as periodontitis and tooth avulsion. However, regenerating periodontal tissue is a huge clinical challenge because of the structural complexity and the poor self-healing capability of periodontal tissue. Tissue engineering has led to advances in periodontal regeneration, however, the source of exogenous seed cells is still a major obstacle. With the improvement of in situ tissue engineering and the exploration of stem cell niches, the homing of endogenous stem cells may bring promising treatment strategies in the future. In recent years, the applications of endogenous cell homing have been widely reported in clinical tissue repair, periodontal regeneration, and cell therapy prospects. Stimulating strategies have also been widely studied, such as the combination of cytokines and chemokines, and the implantation of tissue-engineered scaffolds. In the future, more research needs to be done to improve the efficiency of endogenous cell homing and expand the range of clinical applications.
The characterisation of Wickerhamomyces anomalus M15, a highly tolerant yeast for bioethanol production using seaweed derived medium
Authors: Turner William , Greetham Darren , Du Chenyu
Published: October 2022

Advanced generation biofuels have potential for replacing fossil fuels as society moves forward into a net-zero carbon future. Marine biomass is a promising source of fermentable sugars for fermentative bioethanol production; however the medium derived from seaweed hydrolysis contains various inhibitors, such as salts that affected ethanol fermentation efficiency. In this study the stress tolerance of a marine yeast, Wickerhamomyces anomalus M15 was characterised. Specific growth rate analysis results showed that Wickerhamomyces anomalus M15 could tolerate up to 600 g/L glucose, 150 g/L xylose and 250 g/L ethanol, respectively. Using simulated concentrated seaweed hydrolysates, W. anomalus M15’s bioethanol production potential using macroalgae derived feedstocks was assessed, in which 5.8, 45.0, and 19.9 g/L ethanol was produced from brown (Laminaria digitata), green (Ulva linza) and red seaweed (Porphyra umbilicalis) based media. The fermentation of actual Ulva spp. hydrolysate harvested from United Kingdom shores resulted in a relatively low ethanol concentration (15.5 g/L) due to challenges that arose from concentrating the seaweed hydrolysate. However, fed-batch fermentation using simulated concentrated green seaweed hydrolysate achieved a concentration of 73 g/L ethanol in fermentations using both seawater and reverse osmosis water. Further fermentations conducted with an adaptive strain W. anomalus M15-500A showed improved bioethanol production of 92.7 g/L ethanol from 200 g/L glucose and reduced lag time from 93 h to 24 h in fermentation with an initial glucose concentration of 500 g/L. The results indicated that strains W. anomalus M15 and W. anomalus M15-500A have great potential for industrial bioethanol production using marine biomass derived feedstocks. It also suggested that if a concentrated high sugar content seaweed hydrolysate could be obtained, the bioethanol concentration could achieve 90 g/L or above, exceeding the minimum industrial production threshold.
Methods and criteria for validating the multimodal functions of perinatal derivatives when used in oncological and antimicrobial applications
Authors: Silini Antonietta R. , Ramuta Taja Železnik , Pires Ana Salomé , Banerjee Asmita , Dubus Marie , Gindraux Florelle , Kerdjoudj Halima , Maciulatis Justinas , Weidinger Adelheid , Wolbank Susanne , Eissner Günther , Giebel Bernd , Pozzobon Michela , Parolini Ornella , Kreft Mateja Erdani
Published: October 2022

Perinatal derivatives or PnDs refer to tissues, cells and secretomes from perinatal, or birth-associated tissues. In the past 2 decades PnDs have been highly investigated for their multimodal mechanisms of action that have been exploited in various disease settings, including in different cancers and infections. Indeed, there is growing evidence that PnDs possess anticancer and antimicrobial activities, but an urgent issue that needs to be addressed is the reproducible evaluation of efficacy, both in vitro and in vivo. Herein we present the most commonly used functional assays for the assessment of antitumor and antimicrobial properties of PnDs, and we discuss their advantages and disadvantages in assessing the functionality. This review is part of a quadrinomial series on functional assays for the validation of PnDs spanning biological functions such as immunomodulation, anticancer and antimicrobial, wound healing, and regeneration.
Prevention of mortality in acute lung injury induced by oleic acid: Application of polyherbal decoction (bronco T)
Authors: Mishra Priyanka , Pandey Ratna , Pandey Nikhil , Tripathi Suyash , Tripathi Yamini Bhusan
Published: October 2022

Acute lung injury (ALI) is a lethal respiratory disorder; directed uncontrolled inflammation, sloughing of the alveolar cells and their diffusion, and altered cardiorespiratory parameters with a global mortality rate of 40%. This study was designed to assess the preventive effect of a polyherbal decoction (Bronco T, 1.5 g/kg b. w.) on cardiorespiratory variables in oleic acid-induced ALI in rats. Oleic acid increases the level of neutrophil infiltration leading to pulmonary edema and alters the cardiorespiratory dynamics. The adult male rats were surgically cannulated and treated with intravenous oleic acid (0.38 ml/kg b. w.) to establish the ALI model. Bronco T was pre-administered orally 3 hours before oleic acid. The biophysical, histological, biochemical, and molecular effects were compared with dexamethasone (5 mg/kg b. w. i. p.). The animals were randomly divided into control, lethal, standard, and treatment groups. Respiratory frequency (RF), heart rate (HR), and mean arterial pressure (MAP) were recorded on a computerized chart recorder; arterial blood sample was collected to determine PaO2/FiO2, TNF-α, and MPO. Lipid peroxidation, superoxide dismutase, and catalase activity were evaluated to measure oxidative stress in bronchoalveolar lavage. Additionally, the pulmonary water content, COX-2 expression and histological examination were determined in the lung. A molecular docking study of the active phytoconstituent of BT obtained from HR-LCMS analysis against reported targets (IL-6, COX-2, TNFα, MPO and ENaC) of ALI was carried out. The B.T. pretreatment prevents mortality in comparison to the oleic acid group. It protects the lungs and heart from the detrimental effect of oleic acid, on par with dexamethasone. COX-2 mRNA expression was significantly down-regulated in the treatment group. The reduced level of TNF-α, MPO, SOD and catalase supported the protective effect of B.T. The in silico study revealed strong binding interaction between the phytoconstituent (Galangin 3- [galactosyl-(1–4)-rhamnoside and Beta solamarine] of BT and the reported target. The B.T. pre-administration attenuates the oleic acid-induced mortality and cardiorespiratory toxicity.