bluuebunny/crossref_metadata_2025 huggingface dataset:
The Image of the Homeland in the Lyrics of the Poet of Northeastern China Mu Mutian (Based on the Poems from the Collection Drifting Heart)
Authors:   Amur State University, Tsmykal Olga E. , Yishan Feng ,   Amur State University
Published: April 2022

The relevance of the study is determined by the interest of modern humanities in the processes of the formation of ethnic and national consciousness in China in the first half of the 20th century, which determine the images of perception of a foreign culture and self-perception. The novelty lies in the appeal to the half-forgotten work by Mu Mutian, practically unknown to the Russian-speaking reader. The problem lies in the definition of the connotative meanings of the image of the homeland in the works by Mu Mutian, reflecting the fusion of archetypal ethnic ideas and new attitudes of national consciousness. Research methodology is based on the lexical and semantic analysis of the poet’s literary texts, which represent different connotations of the image of the homeland. The research methods we applied involved biographical, cultural-historical and structural-semantic ones. The authors also turned to the comparative analysis of the translation and the original of the poems studied. The authors came to the conclusion that the image of the homeland in the poems included in the collection Drifting Heart by Mu Mutian is often manifested allegorically. The name Drifting Heart fully reflects not only the emotional state of the emigre poet during the period of writing poems but also the processes of the formation of the basic frames of the national consciousness of the Chinese after the Xinhai Revolution during the civil war. Despite the fact that Mu Mutian’s artistic perception of the world during the period of exile is closely connected with the Japanese aesthetic principle of mononoaware, aestheticizing sadness, and is also inseparable from the symbolist craving for “decline”, the poet fuses the “Chinese” vision of these principles and projects them onto ideas about his native places, the homeland of his ancestors under the rule of Japan, declares faith in the revival of China as a single state.
“Good and Evil are Like Grave Dust…”: the Image of Artistic Reality in the Poem by A. A. Fet
Authors:   Novosibirsk State Medical University, Tsepeleva Nadezhda V.
Published: April 2022

The article is devoted to one of the “eternal” themes and problems of Russian literature and philosophy ‒ the problem of good and evil. The relevance of the study of the problem of good and evil is determined by some simplified consideration of this topic at school and university. Hence, the purpose of the undertaken research is to reveal the ethical and spiritual aspects of the designated problem through the prism of the work by A. A. Fet, to show the commonality of the artistic and philosophical searches of Russian thinkers of the 19th–20th centuries in this area. On the basis of the research undertaken in the article, which was carried out using the historical-philosophical, comparative, hermeneutic and descriptive methods of studying, the available sources on this issue, as well as the method of reconstruction and the method of literary analysis of the main poetic images and ideas of the poem in question, the author showed the peculiarity of recreating the poet of artistic reality in the analyzed poem, which served as the basis for the poetic solution of the “eternal” theme. The article notes that the readers are presented with the Christian picture of the world and the Christian understanding of the problem of good and evil, with its highlighting of the moral and spiritual aspects. The author of the article, referring to the poem by A. A. Fet as an illustration, shows, on the one hand, the unequal moral and spiritual aspects of the problem of good and evil, and on the other hand, their relationship. The article concludes that the ability to distinguish between the moral and spiritual aspects of this problem allows one to comprehend the issue of good and evil more deeply, to get away from its stereotypical dialectical consideration in the context of the idea of free choice. An example of such a deep disclosure of the ethical and philosophical problem in an artistic context can serve, according to the author, a poem by A. A. Fet, consonant with the spiritual quest of Russian religious philosophers of the 19th–20th centuries.
Axiology of Transbaikal Territory Media Image
Authors:   Transbaikal State University, Erofeeva Irina V. , Prostakishina Natalya V. ,   State Television and Radio Broadcasting Company-Chita – a branch of the All-Russian State Television and Radio Broadcasting Company
Published: April 2022

Region’s media image modelling is a very topical problem of the information age from the view of productive functioning of territories, their socio-economic and political status. The article presents the role of values in the media image structure, analyzes axiological components of the Transbaikal Territory media image, and shows its cultural and content characteristics. Research findings are based on some data from a sociological survey carried out in 2021, where 911 residents of the region of different ages (20 to 68) took part, as well as the results of a survey of 48 regional journalists from different communication channels. The attention is paid to the conceptual component of the Region Media Image, as well as to the special role of the actor of multimedia content.Typological and cognitive analyses allowed us to identify the empirical material and present it as a system of cultural and historical dominant ideas. Major characteristics of media image axiology are based on linguocultural approach, emphasizing the values of traditional culture. Media image axiology presents a triple-stage system with its regional specific features, distinct content including spiritual and moral, cultural and historical, and natural values. Spiritual and moral priorities reflect region’s mental view of the world and focus on the values of labour, kindness, grace, sincerity and patriotism, preservation of family values, faith in justice. Cultural and historical context is enriched by the folk heroes of the past and present, traditions, beliefs and customs. Coronavirus pandemic made actors of information flows focus on natural resources of Transbaikalia. During the study, we revealed a correlation between the axiological instrumentation of designing the media image of the region and the level of influence of the media discourse on the consumer, between the spiritual and moral picture of the author’s view of the world and the demand for media products by the audience. We justify the need to adjust the work of regional journalists with a texture inherent in modelling the media image of the region.The authors make a conclusion that, on the one hand, a productive media image is designed using values and ideals characteristic of the territory, on the other hand, the cultural and historical space of the region is a tool for necessary identification with a place of residence, a link between generations and residents of the region.
DOMINASI BRAND MINDED DAN MULTI-BRAND LOYALTY DALAM PEMBELIAN PRODUK DENGAN LUXURY BRAND
Authors: Shidiqy Dhiya'u , Setiawan Rendi
Published: April 2022

Abstrak: The purpose of this study was to determine the dominance of the influence of brand minded and multi-brand loyalty on product purchasing decisions with luxury brands. The population in this study are young entrepreneurs who are members of the Indonesian Young Entrepreneurs Association (HIPMI) Tulungagung. The sample measurement guidelines use the saturated sample technique with a sample of 53 people. The research instrument for data collection in this study used a questionnaire with a Likert scale with data analysis techniques in this study, including descriptive statistical techniques, inferential statistical analysis with classical assumption tests, as well as hypothesis testing with F test and t test with SPSS 23 application. Results The t-test in this study shows that brand mindedness has a positive and significant effect on purchasing decisions for products with luxury brands. Meanwhile, multi-brand loyalty has no effect on respondents' interest in their decision to purchase products with luxury brands. The results of the F test in the study prove that simultaneously brand minded and multi-brand loyalty have an influence on product purchasing decisions with luxury brands.
Kata Kunci: brand minded; multi-brand loyalty; luxury brand
 
Abstract: Tujuan penelitian ini untuk mengetahui dominasi pengaruh brand minded dan multi-brand loyalty terhadap keputusan pembelian produk dengan luxury brand. Populasi pada penelitian ini adalah para pengusaha muda yang tergabung dalam Himpunan Pengusaha Muda Indonesia (HIPMI) Tulungagung. Pedoman pengukuran sampel menggunakan teknik sampel jenuh dengan sampel sejumlah 53 orang. Instrumen penelitian untuk pengumpulan data dalam penelitian ini menggunakan kuesioner dengan skala likert dengan teknik analisis data pada penelitian ini antara lain dengan teknik statistik deskiptif, analisis statistik inferensial dengan uji asumsi klasik, serta pengujian hipotesis dengan uji F dan uji t dengan aplikasi SPSS 23. Hasil uji t pada penelitian ini menunjukkan bahwa brand minded berpengaruh positif dan signifikan terhadap keputusan pembelian produk dengan luxury brand. Sedangkan multi-brand loyalty terbukti tidak berpengaruh terhadap minat responden dalam keputusannya melakukan pembelian produk dengan luxury brand. Hasil uji F pada penelitian membuktikan bahwa bahwa secara simultan brand minded dan multi-brand loyalty memiliki pengaruh terhadap keputusan pembelian produk dengan luxury brand.
Keywords: brand minded; multi-brand loyalty; luxury brand
REALITAS SUBJEKTIF DAN OBJEKTIF AL-QUR’AN DALAM TRADISI MITONI
Authors: Rosa Sabbrina Laila , Bakhri Syamsul
Published: April 2022

Abstrak:. Artikel ini membahas mengenai realitas subjektif dan objektif Al-Qur’an dalam tradisi mitoni. Penelitian ini termasuk dalam jenis penelitian lapangan dengan teori kontruksi sosial dari Petter L Berger yang menekankan pada makna dan penafsiran bersama yang dikontruksi dalam jaringan masyarakat. Tujuan Penelitian ini untuk mengetahui Realitas Objektif Al-Qur’an dalam tradisi Mitoni dan Realitas Subjektif Al-Qur’an dalam tradisi Mitoni yang ada pada Masyarakat di Kelurahan Gumawang. Metode yang digunakan dalam penelitian ini adalah Kualitatif dengan paradigma Naturalistik dan melalui pendekatan fenomenologi. Pengumpulan data dilakukan dengan cara observasi, wawancara, dan dokumentasi dari sumber data primer dan sumber data sekunder. Sedangkan analisis data dilakukan secara Fenomenologi-Kualitatif. Hasil penelitian ini menunjukkan bahwa Realitas Subjektif masyarakat menganggap tradisi mitoni sangat sakral dan diyakini apabila tidak melakukan dipercayai akan menimbulkan mara bahaya serta menyebabkan kemusyrikan dan termasuk menyembah selain Allah, pemikiran mereka berlandaskaan pada Al-Qur’an QS.Al-maidah:76 telah menjelaskan tidak boleh menyekutukan Allah. Sedangkan Realitas Objektif Masyarakat dalam tradisi Mitoni ini bahwa Tradisi ini sudah terinternalisasi pada masyarakat, selalu dilakukan, dieksternalisasikan, diobjektifikasikan, hingga menjadi hal yang populer dan masih dilakukan dari zaman nenek moyang hingga saat ini.
Kata Kunci: Realitas Subjektif; Realitas Objektif; Al-Qur’an
 
Abstract: This article discusses the subjective and objective reality of the Qur'an in the mythological tradition. This research is included in the type of field research with the social construction theory of Petter L Berger which emphasizes the shared meaning and interpretation constructed in community networks.The purpose of this study was to determine the subjective reality of the Qur’an in the Mitoni tradition and the subjective reality of the Koran in the Mitoni tradition that existed in the community in the Gumawang Village.the method used in this research is qualitative with naturalistic paradigm and through phenomenological approach.Data was collected by means of observation, interviews, and documentation from primary data sources and secondary data sources.while the data analysis was carried out in a phenomenological-qualitative way. The results of this study indicate that the Subjective Reality of the community considers the mitoni tradition to be very sacred and is believed if not doing it is believed to cause harm and cause polytheism and includes worshiping other than Allah, their thinking is based on the Qur'an QS. Al-Maidah: 76 has explained cannot associate with Allah. Meanwhile, the Objective Reality of the Society in the Mitoni tradition is that this tradition has been internalized in society, always carried out, externalized, objectified, until it becomes a popular thing and is still practiced from the time of the ancestors to this day.
Keywords: Subjective Reality;Objective Reality; Al-Qur’an
Improved Soluble Expression in Escherichia coli and Easily Purified
Recombinant Human Bone Morphogenetic 7-2 Fusion Protein
Authors: Wang Shuai , Lai Min , Cui Yaqian , Fan Hongwei , Huang Kaizong
Published: April 2022

Background:

Bone morphogenetic protein (BMP) is a cysteine-rich growth factor and
plays a key role in early bone tissue development and bone defect repair. However, the low yield,
high cost and complicated process in BMP significantly limit its clinical application.

Objective:

In this study, we developed an efficient method for soluble expression and preparation of
recombinant human bone morphogenetic 7-2 fusion protein (rhBMP7-2) and determined its
molecular weight and biological activity.

Methods:

The fusion gene for rhBMP-2 and rhBMP-7 was inserted into the pET-ELP expression
vector. Correct DNA sequence was confirmed, the rhBMP7-2-ELP was transformed into
Escherichia coli strain BL21 (DE3), and the rhBMP7-2 was produced in the recombinant E. coli.
Recombinant BMP7-2 purify was identified using Sodium Dodecyl Sulfate Polyacrylamide Gel
Electrophoresis (SDS-PAGE). The cell proliferation and biological activity of rhBMP7-2 were
measured by Cell Counting Kit-8 and Alkaline Phosphatase assay using C2C12 cells, respectively.

Results:

The result of digestion of NdeI, BamHI and XhoI enzymes showed that the rhBMP7-2-ELP
was correctly constructed. The recombinant BMP7-2 was successfully expressed in soluble form;
the purified rhBMP7-2 showed biological activity and significantly promoted cell proliferation and
differentiation in a dose-dependent manner.

Conclusion:

The rhBMP7-2 fusion protein with osteogenic activity was prepared through a lowcost
and time-efficient method. Our preparation method presents the potential to be applied to the
large-scale production of rhBMP7-2 and is expected to play a significant role in clinical treatment.
Diammonium Glycyrrhizinate Preparation for Liver Function Recovery in Chronic
Hepatitis B in China: A Meta-analysis with Trial Sequential Analysis
Authors: Liu Yibo , Guo Wenfang , Li Minhui
Published: April 2022

Background:

The treatment of chronic hepatitis B (CHB) comprises a global medical problem, and the first-line clinical drugs have obvious shortcomings. The use of the plant extract diammonium glycyrrhizinate (DG) in food and medicine has gradually widened because of its safety and effectiveness. In clinical practice, DG is mainly used for liver-disease treatment, but DG intervention for CHB lacks systematic-based evidence.

Method:

: The included randomized controlled trials were analyzed by comparator and control respectively for alanine aminotransferase (ALT), aspartate transaminase (AST), and total bilirubin (TBIL) levels, hepatitis B virus DNA negative conversion ratio, and total effective rate, and subgroup analysis was conducted for intervention time, intervention dosage form, comparator drug, and combination drug, among others. Trial sequential analysis was used to verify the results.

Result:

DG could effectively reduce ALT, AST, TBIL, and other liver-function indexes and had a definite effect on liver-function recovery. From the beginning of intervention to 3 months, the effect was significantly better than that of conventional treatment. Compared with other drugs, different dosage forms had differences in efficacy, and DG enteric-coated capsules and injections were lower than compound glycyrrhizin and magnesium isoglycyrrhizin. Meanwhile DG capsules had no significant difference with them. Meanwhile, trial sequential analysis of the main results confirmed the reliability of the conclusion.

Conclusion:

To our knowledge, this was the first relatively complete meta-analysis and systematic evaluation of the efficacy of DG intervention for CHB; liver-function recovery was discussed in the context of traditional Chinese medicine thinking, and DG’s therapeutic effect in CHB was defined.
Impacts of COVID-19 in Breast Cancer: From Molecular Mechanism to
the Treatment Approach
Authors: Acco Alexandra , Stipp Maria Carolina , Corso Claudia Rita
Published: April 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected
more than 272 million people, resulting in 5.3 million deaths worldwide from COVID-19. Breast
tumors are considered the world’s most commonly diagnosed cancer. Both breast cancer and
COVID-19 share common pathogenic features, represented by inflammatory mediators and the potential
of SARS-CoV-2 replication in metastatic cancer cells. This may intensify viral load in patients,
thereby triggering severe COVID-19 complications. Thus, cancer patients have a high risk of
developing severe COVID-19 with SARS-CoV-2 infection and a higher rate of complications and
death than non-cancer patients. The present review discusses common mechanisms between
COVID-19 and breast cancer and the particular susceptibility to COVID-19 in breast cancer patients.
We describe the effects of chemotherapeutic agents that are used against this cancer, which should
be considered from the perspective of susceptibility to SARS-CoV-2 infection and risk of developing
severe events. We also present potential drug interactions between chemotherapies that are used to
treat breast cancer and drugs that are applied for COVID-19. The drugs that are identified as having
the most interactions are doxorubicin and azithromycin. Both drugs can interact with each other and
with other drugs, which likely requires additional drug monitoring and changes in drug dosage and
timing of administration. Further clinical and observational studies involving breast cancer patients
who acquire COVID-19 are needed to define the best therapeutic approach when considering the
course of both diseases.
Mechanochemical Promoted Heterocycles: A Solvent-free Route to
Triazole Carbohydrates as Glycogen Phosphorylase Inhibitors
Authors: Guesmi Ahlem , Abdulfattah Wesam , Ticha Manel Ben , Algathami Faisal K. , Aouadi Kaiss , Houas Ammar , Khezami Lotfi , Hamadi Naoufel Ben
Published: April 2022

Aims:

This study aimed to recommend a novel way for the preparation of carbohydrates containing
triazole derivatives.

Background:

Triazoles containing derivatives have numerous biological activities. Ball milling is a fast,
modest, green process with massive potential. One of the greatest interesting applications of this technique
is in the arena of heterocycles.

Objective:

Solvent-free click reactions are facilitated via the activation of copper powder using a ball milling
mechanochemical procedure. An optimization study of parameters affecting the reaction rate, such as
reaction time, size, and milling ball number, has been conducted. Different substrates have been tested using
this adopted procedure considering in all cases, in high yields and purity, the corresponding chiral optically
pure five-membered glycoconjugates containing 1,2,3-triazole.

Method:

Three milling balls of 10 mm in diameter were placed in the milling jar (50 mL; stainless steel). 1
mmol of alkyne, 2 mmol of azide, and 1 mmol of Cu powder (63 mg) were added, respectively, in the presented
order. Milling was assured for 25 min at 650 rpm deprived of solvent.

Result:

The cycloaddition results and the deprotection of the cycloadducts were affected by the selection of
the protective groups. Cleavage of the acetyl protecting groups provided water-soluble triazoles. The four
1,4-di-substituted 1,2,3-triazoles synthesized via deacetylation were tested against glycogen phosphorylase.
The best inhibitor of rabbit muscle glycogen phosphorylase was 2-Amino-3-{2-[1-(3,4,5,6-tetrahydroxytetrahydro-
pyran-2-ylmethyl)-1H-[1,2,3]triazol-4-yl]-ethylsulfanyl}-propionic acid b (Ki = 40.8±3.2 μM).
This novel procedure affords an eco-friendly reaction profile (catalyst-free) affording high yields and short
reaction times.

Conclusion:

In this work, acetyl protective groups were used to the corresponding deprotected watersoluble
triazole analogous to recognizing glycogen phosphorylase inhibitors. Triazole 6a was the most effective
inhibitor of RMGP b with a Ki value of 40.8 μM.
The Utility of Various Pre-anesthetic Medications Based on Type of General
Anesthesia
Authors: Mahmood Adnan Hussein
Published: April 2022

Background:

Premedication is used prior to surgery to reduce the adverse effects that
might result from general anesthesia.

Objective:

This study was performed to examine the types and utility of various pre-anesthetic agents
in 100 patients aged between 3 and 60 years who were admitted to Baladrooz General Hospital for different
surgical operations during February (winter) and April (spring) 2021.

Methods:

A total of 62 patients received isoflurane, and 7 patients received sevoflurane, both by inhalational
administration. The other 31 subjects were administered Marcaine (bupivacaine) by spinal anesthesia.

Results:

In this study, eight types of pre-anesthetic medication were administered prior to anesthesia,
as follows: hydrocortisone (35 patients), metoclopramide (25 patients), atropine (13 patients), dexamethasone
(12 patients), midazolam (7 patients), morphine (3 patients), ephedrine (3 patients), and fentanyl
(2 patients).
The most commonly used pre-anesthetic agent administered with isoflurane was hydrocortisone (37
patients), while the least used were fentanyl and morphine, which were administered to 3 patients
each. Hydrocortisone was the premedication most often used (6 patients) with isoflurane, followed by
dexamethasone, midazolam, and metoclopramide (5, 2, and 2 patients, respectively). The preanesthetic
agent used most often with sevoflurane was hydrocortisone (6 patients), followed by dexamethasone
(5 patients) and metoclopramide and midazolam (2 patients each). The premedication most
commonly used with bupivacaine was metoclopramide (25 patients), while the least used was midazolam
(2 patients).

Conclusion:

The study showed that several different pre-anesthetic drugs were used prior to anesthetic
agents, which suggests that the selection of a pre-anesthetic drug depends on the risks that might be
incurred when using a specific anesthetic drug.
Egg Quality and Chemical Components of Arabic and Commercial Chicken Enriched with Omega 3 During Storage
Authors: Wulandari Zakiah , Hidayati Iman Rahayu , Andriani Risha
Published: April 2022

The aim of this research was to study the effect of storage periode and egg types on quality and chemical components of DHA enriched egg. One hundred and twenty six each control and DHA enriched eggs used in this research. The research had been implemented using the general linier models procedure included the storage period and eggs treathment and interaction between these factors, comparison test is calculated based on Tukey Test. Internal egg quality was observed, eq,: weight of egg, yolk color and water activity. Internal quality were influenced by egg type. Albumen height and haugh unit value were influenced by both type of chicken and storage periods. Fat and cholesterol levels of egg DHA-rich Arabic and commercial were lower than those of control. However, the percentage of omega-3 fatty acids components were higher in DHA-rich Arabic and commercial than in control eggs.
Смещение предела устойчивости течений при наличии случайных флуктуаций скорости вращения
Authors: Жиленко Д.Ю. , Кривоносова О.Э.
Published: April 2022

Nonlinear stability of the isothermal three-dimensional flows of viscous incompressible fluid in the rotational spherical layer with the noise presence was studied numerically. Transition between stable non-stationary flow and unstable flow in the form of travelling azimuthal waves is under consideration. Small-amplitude noise inserted to the flow by random broadband disturbances of the inner sphere rotational rate about constant at time averaged value, outer sphere is fixed. An approach is proposed to simplify finding the critical Reynolds number, corresponding to the stability limit in the presence of noise. The results obtained by the proposed and well known methods are compared.
Оже-анализ оксида таллия, сформированного с использованием низкоэнергетического пучка ионов кислорода
Authors: Ашхотов О.Г. , Ашхотова И.Б.
Published: April 2022

The effect of irradiation with low-energy oxygen ions on the composition and some properties of the layer formed on the thallium surface has been studied. It is shown that bombardment with oxygen ions leads to the formation of a two-dimensional oxide layer, which effectively passivates the surface.
Электрические и оптические свойства тонких пленок оксида кобальта, полученных методом ионно-лучевого распыления
Authors: Габриельс К.С. , Калинин Ю.Е. , Макагонов В.А. , Панков С.Ю. , Ситников А.В.
Published: April 2022

Optical and electrical properties of cobalt oxide thin films obtained by ion-beam sputtering in argon atmosphere and argon with the addition of oxygen (PAr = 1.1∙10-5 Torr) has been investigated in the work. Optical properties investigations showed that, for films of cobalt oxide obtained in argon atmosphere, the optical band gap is independent of the film thickness and is 3.24 eV, which is in the range of given in the literature for the CoO phase values. For cobalt oxide films obtained in mixed atmosphere of argon with the addition of oxygen, two direct optical transitions with energies of 1.45 and 2.1 eV were detected. The presence of two direct allowed optical transitions is associated with the variable valence of cobalt in the Co3O4 compound and the presence of two valence states Co2+ and Co3+.
The dependences of specific electrical conductivity of the synthesized films on the magnitude of the electric field were studied. It was found that for all investigated samples, the electrical conductivity does not depend on the electric field strength up to the value of E = 106 V/m. The nonlinearity of the dependence of specific electrical conductivity of the synthesized films on electric field strength at E > 106 V/m is discussed in terms of the hopping conductivity model and the trap ionization model described by the Poole–Frenkel effect.
Integrating Google Trends Search Engine Query Data Into Adult Emergency Department Volume Forecasting: Infodemiology Study
Authors: Trevino Jesus , Malik Sanjeev , Schmidt Michael
Published: April 2022

Background

The search for health information from web-based resources raises opportunities to inform the service operations of health care systems. Google Trends search query data have been used to study public health topics, such as seasonal influenza, suicide, and prescription drug abuse; however, there is a paucity of literature using Google Trends data to improve emergency department patient-volume forecasting.

Objective

We assessed the ability of Google Trends search query data to improve the performance of adult emergency department daily volume prediction models.

Methods

Google Trends search query data related to chief complaints and health care facilities were collected from Chicago, Illinois (July 2015 to June 2017). We calculated correlations between Google Trends search query data and emergency department daily patient volumes from a tertiary care adult hospital in Chicago. A baseline multiple linear regression model of emergency department daily volume with traditional predictors was augmented with Google Trends search query data; model performance was measured using mean absolute error and mean absolute percentage error.

Results

There were substantial correlations between emergency department daily volume and Google Trends “hospital” (r=0.54), combined terms (r=0.50), and “Northwestern Memorial Hospital” (r=0.34) search query data. The final Google Trends data–augmented model included the predictors Combined 3-day moving average and Hospital 3-day moving average and performed better (mean absolute percentage error 6.42%) than the final baseline model (mean absolute percentage error 6.67%)—an improvement of 3.1%.

Conclusions

The incorporation of Google Trends search query data into an adult tertiary care hospital emergency department daily volume prediction model modestly improved model performance. Further development of advanced models with comprehensive search query terms and complementary data sources may improve prediction performance and could be an avenue for further research.
Effectiveness of Silver Diamine Fluoride for Preventing Occlusal Caries in the Primary Teeth of Preschool Children: Protocol for a Randomized Controlled Trial
Authors: Duangthip Duangporn , He Shuyang , Gao Sherry Shiqian , Chu Chun Hung , Lo Edward Chin Man
Published: April 2022

Background

Tooth decay is a significant public health problem globally. The caries-arrest effectiveness of 38% silver diamine fluoride (SDF) has been well documented. However, information on the caries-preventive effect of SDF on primary teeth is insufficient.

Objective

The aim of this trial is to investigate the effectiveness of semiannual application of 38% SDF and that of 5% sodium fluoride (NaF) varnish when compared with placebo control for preventing occlusal caries in the primary molars of preschool children over 30 months.

Methods

This 3-arm, parallel design, double-blind, randomized controlled trial involves 791 preschool children. Children are randomly allocated to receive 1 of 3 interventions as follows: Group 1, 38% SDF; Group 2, 5% NaF varnish; and Group 3, placebo control (tonic water). The intervention and dental examination will be carried out every 6 months. A parent-administered questionnaire, including the children’s demographic background and oral health–related behaviors, has been collected at baseline. Follow-up examinations to detect new caries development will be conducted every 6 months by a masked examiner. Caries development will be diagnosed at the cavitation level. Chi-square tests and logistic regression analyses will be adopted. A 2-level logistic regression analysis will be performed to investigate the effects of the study interventions and other potential confounding factors on the development of occlusal caries.

Results

This study was started on September 1, 2020, and the recruitment process ended on September 30, 2021. At present, a total of 791 children are participating in the study. This 30-month clinical trial is expected to be completed in March 2024.

Conclusions

If SDF application is more effective than NaF varnish for preventing caries on occlusal surfaces of primary teeth, it can be a preferred choice for caries prevention in a kindergarten-based program. Results of this trial will provide valuable clinical evidence for the development of oral health strategies and policies on the promotion of child oral health.

Trial Registration

HKU Clinical Registry HKUCTR-2844, https://tinyurl.com/bdhz9yuk; ClinicalTrials.gov NCT05084001, https://clinicaltrials.gov/ct2/show/NCT05084001

International Registered Report Identifier (IRRID)

DERR1-10.2196/35145
COVID-19 Return to Sport: NFL Injury Prevalence Analysis
Authors: Puga Troy B , Schafer Joshua , Agbedanu Prince N , Treffer Kevin
Published: April 2022

Background

Sport injuries have been common among athletes across the globe for decades and have the potential to disrupt athletic careers, performance, and psyche. Many health professionals and organizations have undertaken injury mitigation strategies to prevent sport injuries through protective equipment, training protocols, and a host of other evidence-based practices. Many of these specialized training methods were disrupted due to protocols to mitigate the spread of COVID-19. This research examines the effects of the COVID-19 pandemic in relation to the prevalence of athletic injuries in the National Football League (NFL).

Objective

During the COVID-19 pandemic, NFL teams and athletes across all levels of sport were reported to have reduced training in preparation for their seasons due to protocols to mitigate the spread of COVID-19. This study compares the prevalence of injury during the 2018, 2019, and 2020 NFL seasons, with the aim to determine the potential causes of the differences in injury prevalence.

Methods

Official injury reports from each team were counted during the 17-week regular season of each year (2018, 2019, and 2020). The data were analyzed using an unpaired t test to compare the injury prevalence between each of the three seasons.

Results

The 2018 season produced a total of 1561 injuries and a mean of 48.8 injuries per team. The 2019 season produced a total of 1897 injuries and a mean of 59.3 injuries per team, while the 2020 season produced a total of 2484 injuries and a mean of 77.6 injuries per team. An unpaired t test was performed using the data to compare the mean number of injuries per team during each of the seasons. Comparison of the 2020 season against the 2019 season showed a statistically significant difference (P<.001); comparison of the 2020 season to the 2018 season found a statistically significant difference (P<.001); and comparison between the 2019 and the 2018 seasons found a statistically significant difference (P=.03).

Conclusions

Although the 2019 and 2018 seasons showed a statistically significant difference (P=.03), this difference is not as large when we compare the 2020 seasons versus the 2019 (P<.001) and 2018 (P<.001) seasons. The astronomical increase in injury prevalence during the 2020 season over the previous years raises the possibility that there was a reduced physiological adaptation to stress, due to the limited amount of training as a result of the closure of practice facilities in order to slow the spread of COVID-19.
Crowdsourcing Medical Costs in Dermatology: Cross-sectional Study Analyzing Dermatologic GoFundMe Campaigns (Preprint)
Authors: Mark Erica , Sridharan Mira , Florenzo Brian , Schenck Olivia L , Noland Mary-Margaret B , Barbieri John S , Lipoff Jules B
Published: April 2022

BACKGROUND

Crowdfunding for medical costs is becoming increasingly popular. Few previous studies have described the fundraising characteristics and qualities associated with success.

OBJECTIVE

This study aimed to characterize and investigate the qualities associated with successful dermatological fundraisers.

METHODS

This cross-sectional study of dermatological GoFundMe campaigns collected data, including demographic variables, thematic variables using an inductive qualitative method, and quantitative information. Linear regression examined the qualities associated with success, which are defined based on funds raised when controlling for campaign goals. Logistic regression was used to examine qualities associated with extremely successful campaigns, defined as those raising >1.5 times the IQR. Statistical significance was set at P<.05.

RESULTS

A total of 2008 publicly available campaigns at the time of data collection were evaluated. Nonmodifiable factors associated with greater success included male gender, age 20-40 years, and White race. Modifiable factors associated with success included more updates posted to the campaign page, non–self-identity of the campaign creator, mention of a chronic condition, and smiling in campaign profile photographs.

CONCLUSIONS

Understanding the modifiable factors of medical crowdfunding may inform future campaigns, and nonmodifiable factors may have policy implications for improving health care equity and financing. Crowdfunding for medical disease treatment may have potential implications for medical privacy and exacerbation of existing health care disparities. This study was limited to publicly available GoFundMe campaigns. Potential limitations for this study include intercoder variability, misclassification bias because of the data abstraction process, and prioritization of campaigns based on the proprietary GoFundMe algorithm.
Selenium supplements: is it advisable to use them in treatment of pathology of the thyroid gland?
Authors: Katerenchuk V. , Katerenchuk A.
Published: April 2022

The article is a review of the literature in Scopus, Web of Science, MedLine and The Cochrane Library and is devoted to the analysis of the evidence base of the use of selenium supplements for the treatment of thyroid pathology. Despite the variety of thyroid pathology: changes in size and structure, hypo- and hyperfunction, autoimmune, oncopathology, there are not so many drugs used in its medical treatment. Drugs that are justified for various thyroid pathologies include iodine, levothyroxine and, to some extent, triiodothyronine, thyrostatics (methimazole, carbimazole, propylthiouracil), radioactive iodine and glucocorticoids, such as beta-blockers. Acute thyroiditis requires the appointment of antibacterial therapy, and oncopathology— specific chemotherapeutic agents, the effectiveness of which, unfortunately, is not high, and the frequency of appointment is significant. Along with these drugs, selenium drugs have become unprecedented in the last decade in thyroid pathology as a component of possible pathogenetic therapy. These drugs are prescribed to patients with diametrically opposed functional state of the thyroid gland, autoimmune pathology, nodules. It appears that thyroid carcinogenesis remains the only pathology where the use of selenium drugs is not recommended, although there are studies that indicate a link between thyroid cancer and selenium deficiency. The results of clinical studies and meta-analyzes are provided through the prism of a survey of Italian and European endocrinologists on the appointment of selenium drugs for the treatment of relevant thyroid pathology. The lack of evidence base for the use of selenium in most types of pathology of the thyroid gland: autoimmune thyroiditis, overt and subclinical hypothyroidism, Graves’ disease. According to most studies, the supplementation of selenium to therapy increases its plasma level, affects the activity of selenoproteins and level of antithyroid antibodies, but in no way affects the main clinical parameters such as thyroid hormones, levothyroxine dose, clinical symptoms. In general, the use of selenium in thyroid pathology cannot be considered appropriate, except for a mild form of Graves’ orbitopathy. Significant differences in the data of clinical trials and recommendations of thyroid societies with a real frequency of selenium administration by practitioner for the treatment and prevention of thyroid pathology are indicated.
Crecimiento, factor de condición y condición relativa del camarón Tozeuma carolinense (Decapoda: Caridea: Hippolytidae) en la región meridional de la laguna Madre, Tamaulipas, México
Authors: Herrera-Barquín Hiram , Leija Tristán Antonio , Aguilera-González Carlos Javier
Published: April 2022

Se estudió el crecimiento individual, el factor de condición y la condición relativa de Tozeuma carolinense durante las temporadas de lluvias y estiaje en 3 sitios cubiertos por pastos marinos en el área meridional de la laguna Madre de Tamaulipas, México. El material biológico se obtuvo tamizando una muestra superficial equivalente a 1.5 m2. A cada individuo se le midió la longitud total y se registró su peso. Los parámetros analizados para comparar la condición de la población fueron examinados por temporada, para datos agrupados y por sexo, a través de la relación peso-longitud(W = a*Lb), definido mediante el valor de la pendiente (b) y significado por una prueba de t-student (p < 0.05). Un total de 412 individuos fueron identificados y distribuidos en 4 grupos: datos agrupados (DA), machos (M), hembras no ovígeras (HNO) y hembras ovígeras (HOV), de los cuales 307 fueron recolectados en la temporada de lluvias y 105 en la del estiaje. Los especímenes de T. carolinense mostraron que la mayoría de los grupos, en ambas temporadas, se ajustaron a un crecimiento de tipo alométrico, exceptuando los DA en estiaje y las HNO en lluvias que presentaronisometría.
Hábitos alimenticios y consumo de peces exóticos por la nutria neotropical (Lontra longicaudis) en la Reserva de la Biosfera Sierra de Manantlán, Jalisco, México
Authors: Brito-Ríos Juan Guillermo Adrián , Iñiguez-Dávalos Luis Ignacio , Gallo-Reynoso Juan Pablo , Martínez-Rivera Luis Manuel , Flores-Real Carol Alexis
Published: April 2022

La introducción de especies exóticas es la segunda causa de pérdida de biodiversidad a nivel mundial. La nutria neotropical (Lontra longicaudis) es considerada uno de los depredadores tope de los ambientes acuáticos, por lo que su presencia ejerce un control natural sobre otras poblaciones animales. El objetivo de este trabajo fue describir los hábitos alimenticios de la nutria y documentar el consumo de especies de peces exóticos. Se establecieron 4 transectos de 10 km en los ríos Ayuquila-Armería y Marabasco, en la Reserva de la Biosfera Sierra de Manantlán, para recolectarheces, durante los periodos seco y lluvioso de 2018. En el laboratorio, las heces se lavaron, se tamizaron y se secaron en un horno a 70 °C por 24 h, tras lo cual se separaron e identificaron las partes consumidas. Se recolectaron 101 heces en el río Ayuquila-Armería y 93 en el Marabasco. El 80% de la alimentación está compuesta por peces y crustáceos, mientras que el 20% restante incluye insectos, mamíferos, reptiles, anfibios, aves, moluscos y materia vegetal. Se identificaron 16 especies de peces consumidos, de los cuales 5 son exóticos. La nutria neotropical presentauna alimentación oportunista y generalista, basada principalmente en el consumo de peces y crustáceos.
Distribución temporal y uso de hábitat de tortugas negras (Chelonia mydas) en una zona de alimentación del complejo lagunar Ojo de Liebre, Baja California Sur, México
Authors: Reséndiz Eduardo , Ramos-Díaz Amelly Hyldaí , Fernández-Sanz Helena
Published: April 2022

La distribución y patrones de actividad de las tortugas marinas en áreas de alimentación son fundamentales para su conservación y manejo. Estos análisis pueden revelar datos importantes sobre sus historias de vida, además de explicar su frecuencia de presentación en estos sitios, identificando hábitats críticos. En este estudio se identificaron los patronesde distribución temporal de 2 juveniles de tortuga negra para definir las áreas de mayor uso y patrones de movimiento en un área de alimentación dentro del complejo lagunar Ojo de Liebre, México, uno de los principales sitios de alimentación y desarrollo de tortugas negras en la costa del Pacífico. Para ello, se instalaron 2 radiotransmisores de muy alta frecuencia en 2 tortugas negras juveniles que fueron monitoreadas continuamente con intervalos semanales de agosto 2018 a diciembre 2019. Los datos obtenidos permitieron identificar las zonas de mayor uso y la superficie mensual ocupada por tortuga y por temporada. La presencia y distribución temporal de ambas tortugas indicó que el área brinda las condiciones adecuadas para que ellas usen la zona como sitio de alimentación, desarrollo y/o descanso por periodos prolongados, confirmando que las tortugas muestran alta fidelidad a las zonas de alimentación de la península de Baja California.
Metodología para especificar requisitos de gestión documental desde la ingeniería de requisitos
Authors: Del Castillo Guevara Jorge , Torres Ponjuán Deborah
Published: April 2022

Mantener y preservar documentos archivísticos de calidad es hoy una preocupación para la comunidad archivística internacional. Una de las soluciones más aceptadas ha sido especificar requisitos en el campo de la gestión documental. Por lo anterior, se elaboró una propuesta metodológica para especificar requisitos de gestión documental aplicable en cualquier contexto organizacional, de manera rigurosa y didáctica. Se aplicó el análisis documental como método de investigación. Se examinaron cinco experiencias sobre el proceso de ingeniería de requisitos, que sirvieron como referentes para la propuesta metodológica. Se obtuvo una metodología flexible, sustentada en cuatro principios: enfoque de sistema, colaboración, iteración y continuidad, y transparencia. Se organizó en cuatro procesos: elicitación y análisis, documentación, negociación, y validación, cuya ejecución exitosa requiere la aplicación de un conjunto de métodos y técnicas definidos en el estudio.
Flower Extract of Ixora Coccinea as A Natural Indicator in Acid Base Titration
Authors: Sawant Omkar , Jagtap Devendra , Roshan Shah , Satao Prof. Nitin
Published: April 2022

Abstract: Ixora coccinea Linn may be a species of the genus Ixora, that belongs to the Rubiaceae. The present study indicates the utilization of Ixora coccinea flower extract as an acid base indicator in several sorts of acid base titrations. The equivalence point that was obtained by the flower extract was found to be coincident with the equivalence point obtained by standard indicators. The results obtained by the flower extract matched with the result obtained by standard indicator just in case of weak acid and weak base titration. This natural indicator was found to be a really useful, economical, simple and accurate for the said titration.
A Review of Stock Prediction Using Various Machine Learning Techniques
Authors: Paliwal Shekhar , Sharma Shivang
Published: April 2022

Abstract: Stock market prediction is a complex task due huge volume of data that keeps on changing, and various uncertainties and interrelated local and global economic factors. The key to successful stock price forecasting is achieving best results with minimum amount of required input data. Thanks to the development of technology, in recent years more and more research in the field of the prediction is being done and it becomes easier for us to make stock price prediction by using various ways that include machine learning, deep learning and many other such technologies. Many exceptional innovations in the field of Machine Learning, have been enforced to develop a short-term prediction model. This paper surveys a number of resources from research papers that have studied on the topic. Keywords: Stock market, machine learning, artificial intelligence, neural networks, technical analysis.