bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARISON OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF PURIFIED ANTHOCYANIN FROM OSBECKIA ASPERA (L.) BLUME AND OSBECKIA RETICULATA BEDD. USING ANIMAL MODELS
Authors: Lawarence Bosco , K Murugan
Published: January 2019

Objective: The objective of the present work is to isolate, purify, and fractionate anthocyanin from selected Osbeckia species and also to compare the analgesic and anti-inflammatory potentiality using animal models.Methods: Methodologies include extraction of anthocyanin from the in vitro callus culture of Osbeckia aspera and Osbeckia reticulata, purification using amberlite column chromatography, and fractionation by liquid chromatography-tandem mass spectrometry. The analgesic activity was determined by tail immersion method, analgesy meter, hot plate, and acetic acid-induced writhing test. Anti-inflammatory activity was evaluated by carrageenan-induced paw inflammation in mice.Results: Anthocyanin-producing callus cultures were established in MS medium fortified with various combinations of phytohormones and sucrose. Optimal callus formation in O. aspera was initiated on cultures containing 0.5 mg/L of 2, 4-D, and 0.5 mg/L 6-benzylaminopurine (BA). In O. reticulata callus was initiated in the presence of 1.2 mg/L BA and 1.4 mg/L naphthalene acetic acid. The same hormonal combination on extended treatments turned the white friable callus into red compact callus. Anthocyanins obtained from Osbeckia species were purified and fractionated containing malvidin-3-diglucoside, delphinidin, cyanidin aglycone, and peonidin. Purified anthocyanin of O. aspera at the concentrations 50, 100, 150, and 200 mg/kg after 120 min exhibited significant analgesic activity by tail immersion method, in comparison to O. reticulata. However, with hot plate method, anthocyanin of O. reticulata produced a significant analgesic activity even at lower doses (50 and 100 mg/kg) after 120 min. However, in writhing test, theepurified anthocyanin of O. aspera significantly stopped the number of writhes at a dose of 200 mg/kg and also by the anthocyanin of O. reticulata. In the evaluation of anti-inflammatory effect using plethysmometer, anthocyanin at doses of 100,150 and 200 mg/kg started producing anti-inflammatory effect after 30 min, which lasted until 120 min.Conclusion: It is concluded from the present study that the purified anthocyanin of Osbeckia possesses potent analgesic and anti-inflammatory activities.
INCIDENTAL DETECTION OF CARCINOMA IN SITU IN FIBROADENOMA OF BREAST IN A YOUNG WOMAN: A RARE FINDING
Authors: Valerina Kairanna Nikitha , Kumar Singh Brijmohan , P Pavithra
Published: January 2019

Fibroadenoma is the most common benign tumor of the breast in young females. Breast cancer arising within a fibroadenoma is a rare phenomenon. The incidence of carcinoma within a fibroadenoma is reported to be between 0.1% and 0.3% in a screened population, with a peak age of occurrence between the 4th and 5th decade. We present a case of 29-year-old female with ductal carcinoma in situ in a background of fibroadenoma. There is a low percentage of fibroadenomas harboring carcinoma; however, all breast lumps should be seriously managed; extirpation and histological examination is recommended.
ANTIMICROBIAL ACTIVITY OF SOME THAI AROMATIC PLANTS AGAINST ORAL PATHOGENS INDUCING HALITOSIS
Authors: Yasin Plernpit , Wanachantararuk Phenphicha , Jidaphatinoi Jidaphatinoi , Dumri Kanchana
Published: January 2019

Objective: The objective of the present work is to analyze that the extracts of 25 Thai aromatic plants used in Thai food recipes were subjected to evaluated antimicrobial activity against Fusobacterium nucleatum and Streptococcus mutans which have been known as bacterial inducing halitosis.Methods: Disk diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) by broth microdilution were used to determine the antibacterial activity.Results: The results revealed that three plant extracts, namely Piper betle Linn., Eupatorium stoechadosmum Hance, and Alpinia galangal (L.) Wild can inhibit the growth of both halitosis inducing bacteria with strong activity. Among these, the extract of P. betle Linn. is the most effective in inhibiting both bacteria followed by E. stoechadosmum Hance and A. galangal (L.) Wild, respectively. The MIC (mg/ml) values of the extracts which can inhibit F. nucleatum were ranging from 1.56 to 12.50, and the MBCs (mg/ml) values were ranging from 3.125 to 25.00. In addition, the MICs and MBCs of the extracts which can inhibit S. mutans were found that 1.56–25.00 and 3.125–50.00, respectively.Conclusion: The extracts obtained from P. betle, A. galangal, and E. stoechadosmum displayed good activity against F. nucleatum and S. mutans and these extracts could be a potential source of new antimicrobial agents.
IN SILICO MODELING OF MONOMERIC DEXAMETHASONE-INDUCED RAS-RELATED PROTEIN 1 AND RAS HOMOLOG ENRICHED IN STRIATUM: ROLE OF N TERMINUS AND STRUCTURE‑FUNCTION RELATIONSHIP
Authors: Verma Rashmi , Kumar Navin , Thapliyal Ashish
Published: January 2019

Objective: Dexamethasone-induced Ras-related protein 1 (Dexras1) and Ras homolog enriched in striatum (RHES) are the two monomeric small G proteins that belong to Ras superfamily. These two proteins show 62% similarity. Both of these proteins are involved in signaling and modulation of several pathophysiological processes. They have unique GTP binding domain and a unique C and N terminus. C terminus is known to interact with several proteins; however, the role of its unique N terminus is still not known. The three-dimensional (3D) structure of these proteins is also not available in any of the databases yet. This present study approaches bioinformatics tools and servers to predict the 3D structure of these two proteins in silico.Methods: In this study, two bioinformatics servers were used, namely Swiss modeling server and Iterative Threading ASSEmbly Refinement (I-TASSER) server.Results: Both servers developed many alignment templates of Dexras1 and RHES. These alignments were used to develop 3D structure using Pymol. These models have different regions of proteins such as N terminus, GTP-binding domains, effector loop, C terminus, and the unique CAAX site. The models deduce that the N-terminals of both Dexras1 and RHES are unique regions that might possible be dangling out of the protein while it gets inserted into the membrane. We hypothesize that this unique N-terminal might have a distinct role in the modulation of N-type calcium channels.Conclusion: All the models generated show predicted 3D structure of Dexras1 and RHES protein. This study of structural prediction will be helpful in knowing the interaction of Dexras1 and RHES and a step forward to target these two proteins as a novel therapeutic drug.
COMPUTATIONAL ANALYSIS OF COMPOUNDS FROM OCIMUM SANCTUM FOR ANTICANCER ACTIVITY AGAINST ORAL SQUAMOUS CELL CARCINOMA
Authors: Ss Ariya , Joseph Baby , Viijayasri Santhanam , Hopper Waheeta
Published: January 2019

Objective: The objectives of this research are to identify the potentials of active phytochemicals from Ocimum sanctum as anticancer agents, by inhibiting the epidermal growth factor receptor (EGFR), one of the highly expressed proteins inducing metastasis in oral squamous cell carcinoma (OSCC) as well as other cancers.Methods: The phytochemicals found in O. sanctum were identified and downloaded from online chemical databases. The target protein was retrieved from the Protein Data Bank. Virtual screening using glide protocols of high throughput virtual screening and molecular docking using standard precision and extra precision (XP) were carried out. The binding energies and the important physicochemical properties of the compounds were also determined.Results: A total number of 210 compounds from O. sanctum were screened against EGFR. Lipinski rule was followed to find the compounds with favorable drug absorptive properties. The shortlisted compounds, namely luteolin, apigenin, and isothymusin, possess high Glide scores (kcal/mol) of −9.98, −9.51, and −9.45 and binding energies (kcal/mol) of −42.63, −48.28, and −44.95, respectively.Conclusion: Among the three compounds, Isothymusin was not yet been reported to posess anticancer activity. Our study suggest this compound as a potential chemotherapeutic agent for treating OSCC. They function by inhibiting the activity of metastasis - inducing protein EGFR.
SLEEP DISTURBANCE AND QUALITY OF SLEEP AMONG PATIENTS WITH CARDIOVASCULAR DISEASES
Authors: Merin Neenu , Antony Regina
Published: January 2019

Objective: This was a descriptive study with the objective to determine the sleep disturbances and the quality of sleep among patients with cardiovascular diseases (CVDs).Methods: Quantitative approach with non-experimental descriptive design was used. A semi-structured sleep disturbance questionnaire was used to determine the sleep disturbances, and a standardized Pittsburgh Sleep Quality Index tool was used to assess the sleep quality among 100 subjects in Amrita Institute of Medical Sciences, Kochi.Results: The study results showed that majority of the subjects (51%) were of the age group between 56 and 65 years, and 71% were male with CVD. Sleep disturbances were present in 80% of the subjects with CVD, among which 56% subjects had mild disturbances, 20% subjects with moderate sleep disturbances, and 4% subjects with severe sleep disturbances. The result also indicated that 48% of subjects had poor sleep quality. Findings also showed a highly statistically significant association between cardiomyopathy and sleep disturbances (p<0.001). Total cholesterol and low-density cholesterol levels were significantly associated with sleep disturbances (p<0.05). There is a highly significant association between sleep disturbances and quality of sleep (p<0.001), indicating that sleep disturbances can be one factor in decreasing the quality of sleep in patients with CVD.Conclusion: The results of the study indicated that sleep disturbances were prevalent in patients with CVD and often hazardous to heart health. As health practitioner and other health-care providers have not focused major attention on the importance of sleep to health, the need for providing information to them and patients regarding the importance of improving the quality of sleep and identifying the sleep disturbances will call for action to bring sleep to the forefront of public health.
ANTICANCER ACTIVITY OF MICRO-ALGAE EXTRACT ON HUMAN CANCER CELL LINE (MG-63)
Authors: James Jimcy , Thomas Jibu
Published: January 2019

Objective: The objective of the present study is to assess the anticancer effect of limnic algae extract of KACC 2 (Karunya Algae Culture Collection) and KACC 23 against MG-63 cell line.Methods: Bioactive compounds were extracted from the algae culture by Soxhlet extraction method using methanol as solvent, and the extract was checked for its anticancer activity. Polyphenols were estimated using Folin-Ciocalteu reagent method. The constituents of the extract were analyzed using gas chromatography-mass spectrometry (GC-MS).Results: The results showed that KACC 2 had more phenolic content than KACC 23. The half maximal inhibitory concentration value for KACC 2 and 23 was found as 0.386 μl/ml and 0.285 μl/ml of extracts necessary for the 50% of cell death. GC-MS analysis revealed that the compounds with possible therapeutic effects are quercetin, stigmast-4-en-3-one, epoxygedunin, which has got anticancer activity.Conclusion: These observations point out that the algae extract of KACC 2 and KACC 23 has anticancer property and the phytoconstituents contributed to the anticancer effects.
ANTI-INFLAMMATORY ACTIVITY OF PARTIALLY PURIFIED LECTIN FROM PRAECITRULLUS FISTULOSUS PHLOEM EXUDATES.
Authors: Cs Madhu , Ac Sharada
Published: January 2019

Objective: The objective of the present study is to determine the anti-inflammatory effect of a partially purified lectin from phloem exudates againstpaw edema mice model.Methods: Partially purified lectin was prepared by phloem exudates in phosphate buffer saline followed by ammonium sulfate precipitation anddialysis. Anti-inflammatory activity was determined against carrageenan-induced mice model and inhibition of nitric oxide (NO) production wasdetermined.Results: Partially purified lectin exhibited promising anti-inflammatory activity at 50 mg/kg b.w. by reducing the edema volume significantly up to64% (**p<0.01) against control mice. Decrease in myeloperoxidase activity and NO production in paw exudates was observed up to 55.90 (*p<0.05)and 47.22% (*p<0.05), respectively, and this supports the anti-inflammatory property of the partially purified lectin.Conclusion: This finding indicated that further studies needed to purify and characterize a novel lectin from Praecitrullus fistulosus for elucidating themolecular mechanism of anti-inflammatory activity.
BIOFABRICATION OF ZINC OXIDE NANOPARTICLES USING PTEROCARPUS MARSUPIUM AND ITS BIOMEDICAL APPLICATIONS
Authors: Rajan Abhinaya Shymala , Padmini Ramakrishnan
Published: January 2019

Objective: The objective of the study is to perform the synthesis of zinc oxide nanoparticles using the bark extract of Pterocarpus marsupium and to evaluate its biomedical applications.Methods: Various concentrations of zinc acetate are used, and synthesis conditions were optimized to get a stable nanoparticle. The finest synthesis condition for zinc oxide nanoparticle production was at pH 7 with 20 ml extract, zinc acetate 10 mM, and 120 min of reaction time. The synthesized nanopowder was characterized using various analytical techniques, such as ultraviolet (UV)-visible spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The synthesized nanoparticles were tested for their antimicrobial, anti-inflammatory, inhibition of lipid peroxidation, and inhibition of amylase activity.Results: The size range of nanoparticles obtained was in the range of 10–32 nm as reported by SEM. The UV-visible absorption spectrum of the synthesized nanoparticle showed a peak at 340 nm, which confirmed the presence of nanoparticles. FTIR spectroscopy analysis indicated the presence of zinc oxide stretching at 666.22 cm-1. Further, the IR spectra indicated the presence of alcohols and acids, which can act as capping agents around the nanoparticles. XRD analysis confirmed the crystalline nature of nanoparticles.The synthesized nanoparticle showed appreciable antimicrobial activity. Zinc oxide nanoparticles at 40 μg/well were tested against phytopathogens, Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus flavus, and Aspergillus niger showed 16, 13, 15, and 16 mm zones of inhibition, respectively. The synthesized nanoparticle showed a considerable increase in inhibition of lipid peroxidation and amylase activity. The nanoparticle also exhibited appreciable anti-inflammatory activity measured by the inhibition of albumin denaturation.Conclusion: The study instigates the simple and convenient method of synthesizing zinc oxide nanoparticles using P. marsupium and its few biomedical applications.
ANTIDEPRESSANT-LIKE ACTIVITY OF FLOWERS OF TECOMELLA UNDULATA IN MICE SUBJECTED TO CHRONIC UNPREDICTABLE MILD STRESS
Authors: Dhingra Dinesh , Deepak Deepak
Published: January 2019

Objective: Flowers of Tecomella undulata have been reported to be a rich source of flavonoids such as rutin and quercetin. The present study was designed to evaluate the effect of ethanol extract of flowers of T. undulata on chronic unpredictable mild stress (CUMS)-induced depression in Swiss young male albino mice.Methods: The mice were subjected to CUMS for 21 successive days. Ethanol extract of the flowers (50, 100, and 200 mg/kg, p.o.) and fluoxetine (20 mg/kg, p.o.) per se was administered for 21 successive days to separate groups of unstressed and stressed mice. Tail suspension test (TST) and sucrose preference test were used to evaluate the effect of the extract on depression-like behavior in mice.Results: Extract of flowers of T. undulata (100 and 200 mg/kg) significantly decreased immobility period of stressed mice in TST, indicating significant antidepressant-like activity of the extract. Stress-induced reduced sucrose preference was significantly restored by the extract. There was no significant effect on locomotor activity of mice by the extract and fluoxetine. The extract significantly reversed stress-induced increase in brain malondialdehyde levels; plasma nitrite and corticosterone levels; and also significantly reversed the stress-induced decrease in reduced glutathione and catalase levels. There was no significant effect of the extract on brain MAO-A activity in both unstressed and stressed mice.Conclusion: These results indicated that ethanol extract of flowers of T. undulata showed significant antidepressant-like activity in mice subjected to CUMS, probably through alleviation of oxidative stress and decrease in plasma corticosterone levels.
A PHARMACOGNOSTICAL AND PHARMACOLOGICAL REVIEW ON BRYOPHYLLUM PINNATUM (PANPHUTI)
Authors: Khooshbu Pasha , Ansari Imtiyaz
Published: January 2019

Bryophyllum pinnatum is usually known as Panphuti which belong to family Crassulaceae growing widely in tropical Africa, tropical America, India, China, and Australia. It is a perennial herb grows 3–5 feet tall, fleshy dark green leaves that are distinctively scalloped and trimmed in red, and bell-like pendulous flowers. The plant contains various active compounds such as alkaloids, triterpenes, glycosides, flavonoids, steroids, bufadienolides, lipids, and organic acids. The pharmacological studies are reviewed and discussed, focusing on that different extracts from this plant have anti-inflammatory, antiallergic, antianaphylactic, antileishmanial, antitumorous, antiulcerous, antibacterial, gastroprotective, immunosuppressive, insecticidal, muscle relaxant, sedative, central nervous system depressant, and analgesic. Conventionally, it is used for the treatment of fever, constipation, nourishment of the hair and treating grey hair, intestinal disorder, and leucorrhea. The current review is created with an intended to focus on the numerous ethnobotanical and traditional use as well as the phytochemical and pharmacological report on B. pinnatum.
PHARMACOLOGICAL TREATMENT OF OSTEOPOROSIS IN PATIENTS WITH CORONARY HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE
Authors: Marushchak Mariya , Krynytska Inna
Published: January 2019

Objective: Chronic heart failure (CHF) is a chronic multisystem disorder associated with a myriad of metabolic disturbances. Moreover, CHF may adversely affect bone metabolism and induce a severe bone loss, increasing susceptibility to fractures and osteoporosis. This study investigates the effect of combined calcium with Vitamin D3 supplement called “calcemin advance” and calcitonin in the prophylaxis and treatment of osteopenia and osteoporosis in patients with coronary heart disease (CHD) complicated by CHF with the establishment of their influence on the bone mineral density (BMD).Methods: A total of 59 patients with CHD complicated by CHF. Interventions: The physical examination findings, dual-energy X-ray absorptiometry findings, and treatment results were assessed.Results: The results of the calcemin advance usage in patients with osteopenic changes showed a positive dynamics of the studied parameters, both in the lumbar spine and in the femoral bone. In patients with osteoporosis, the usage of osteoprotective therapy (calcemin advance+miacalcic) contributed to the increasing of BMD in the lumbar spine and in the femoral bone versus patients who received only combined calcium with Vitamin D3 supplement.Conclusions: Our results suggest that bone density screening could be recommended in patients with prevalent CHF. Moreover, the results of our investigation substantiate the necessity and effectiveness of osteoprotective therapy in patients with CHF with osteoporosis by calcitonin (Miacalcic), in combination with combined calcium and Vitamin D3 supplement (calcemin advance), and by only calcemin advance - in patients with CHF and osteopenia.
THE EFFECT OF EXTRACT OF DATE PALM FRUIT (PHOENIX DACTYLIFERA L.) ON FERTILITY IN MALE MICE (MUS MUSCULUS L.)
Authors: Dillasamola Dwisari , A Almahdy , Elfianita Feni , Diliarosta Skunda , Oktomalio P Biomechy , Noverial Noverial
Published: January 2019

Objective: Date palm is one of the plants that have used empirically to increase fertility. Ethanol induction can cause sperm damage in male mice. Sperm damage is one of the infertility agents. The aim of this study was to observe and determine anti-infertility effects of the ethanol extract of date palm fruit in khalal stage in male mice compared with propolis.Methods: A total of 5 groups were assigned to 1 control and 4 experimental groups. Control group was treated by intraperitoneal administration of ethanol only. Meanwhile, experimental groups was treated by intraperitoneal administration of ethanol induction and oral administration of 140, 280, and 560 mg/kg BW of khalal date fruit extract and 1400 mg/kg BW of propolis for 34 days. At 35th day, the mice were deeply anesthetized with anesthetic ether and sacrificed. Laparotomy was performed to collect sperms from epididymis and testes for determining testis weight to analyze the sperm. The data were analyzed using one-way ANOVA and Duncan’s test.Results: The result of the research showed that there were anti-infertility activity of ethanol extract of date palm fruit in khalal stage (p<0.05) on count, motility of sperm and weight of testes in male white mice toghether with larger doses administration. The optimum activity was accepted by the administration of doses 560 mg/kg BW.Conclusion: Ethanol extract of khalal date fruit and propolis can increase the quality of sperm pervade sperm count, sperm motility, and weight of testes. Ethanol extract of khalal date fruit can increase sperm quality higher than propolis.
THE PREVALENCE OF HEPATITIS C VIRUS INFECTION AND POTENTIAL RISK FACTORS AMONG MULTIPLY TRANSFUSED PATIENTS
Authors: Abdul Razak Manal Khudder
Published: January 2019

Objective: Patients who frequently receive blood have high risk of hepatitis C virus (HCV) infection. This study aimed to evaluate the prevalence of HCV infection and potential risk factors among multiply transfused patients.Methods: A cross-sectional retrospective study was conducted in the hemophilia unit in Medical City in Baghdad, between June 1, 2016, and January 1, 2017. After taking consents and approval of ethical comity, the medical records of 1158 patients with hemophilia A and B, von Willebrand disease (vWD), thrombasthenia, Factors VII, X, and XIII deficiencies, and hypofibrinogenemia were analyzed for the presence of HCV antibody using (enzyme-linked immunosorbent assay). Cases of hemophilia were classified into mild, moderate, and severe.Results: The prevalence of HCV infection was 13.2%. Of total, 595 (51.4%) patients had hemophilia A and 99 (16.6%) were anti-HCV positive, while 225 (19.4%) had hemophilia B and 28 (12.4%) were antibody positive compared to 9 (7%) in vWD. Of those with hemophilia A, 515 (86.6%) had severe hemophilia, and 32 (32.32%) cases had acquired HCV infection after 1996 (after introduction of HCV screening in blood banks in Iraq). There was a statistically significant association with treatment by Factor VIII only.Conclusion: The prevalence of HCV in patients with inherited bleeding disorder is 13.2%. In this study, it was found that multitransfusion is the only predictor for HCV infection in this group of patients.
INFLUENCE OF CONSERVATION METHOD (FREEZING AND DRYING) ON COMPOSITION AND CONTENT OF BIOLOGICALLY ACTIVE SUBSTANCES IN ROSACEAE FRUITS (CRUDE HERBAL DRUGS)
Authors: Sergunova Ekaterina Vyacheslavovna , Bokov Dmitry Olegovich
Published: January 2019

Objective: Now, five crude herbal drugs (CHD) of fruit morphological group (fruits) related to Rosaceae family included in the Russian State Pharmacopoeia XI and XIII editions: Fructus Rosae (Rosa cinnamomea L. and other species), Fructus Crataegi (Crataegus sanguinea Pall. and other species), Fructus Sorbi (Sorbus aucuparia L.), Fructus Rubi (Rubus idaeus L.), and Fructus Aroniae (Aronia melanocarpa [Michx.] Elliott).The aim of this study was to investigate the effect of freezing and oven drying on the composition and content of individual groups of biologically active substances (BAS) in Rosaceae fruits.Methods: The groups of BAS were investigated by UV spectrophotometry (flavonoids and anthocyanins), galvanostatic coulometry titration (organic acids), gravimetry (polysaccharides), and titration with potassium permanganate (tannins).Results: The relation between content of BAS (total free organic acids, total flavonoids, total anthocyanins, total tannins, and total polysaccharides) and fruits conservation method was determined. In frozen fruits total polysaccharides, total free organic acids, ascorbic acid content decreases by 5–7%, total flavonoids and total tannins content - 10–15%, total anthocyanins content - 25–30%. Fruits oven drying at 60–80°C leads to more significant losses of total anthocyanins, ascorbic acid, and total free organic acids.Conclusion: The study of BAS stability in frozen and dried fruits was lasting for 12 months. The duration of shelf life for frozen fruits is recommended. Freezing as a conservation method allows to preserve more BAS in Rosaceae fruits. Frozen CHD can be proposed as an alternative to fresh and dried СРВ for the preparation of allopathic and homeopathic medicines.
THE ANTIOXIDANT STUDIES OF TWO MEDICINAL PLANTS, SPHAERANTHUS INDICUS AND PSOPHOCARPUS TETRAGONOLOBUS
Authors: N Vijayalakshmi , Krishna Rao Mudiganti Ram
Published: January 2019

Objective: The present study deals with the antioxidant assays of the different leaf extracts of two medicinal plants, Sphaeranthus indicus and Psophocarpus tetragonolobus. Methods: Dried leaves of S. indicus and P. tetragonolobus were packed in separate round bottom flasks for sample extraction using ethanol, methanol, hexane, and distilled water as solvents for 72 h, and the extracts were collected after evaporating the solvents. Antioxidant studies of the various extracts were performed by 1-diphenyl-2-picrylhydrazyl and Ferric Reducing Ability of Plasma assays.Results: Among the two plants studied, S. indicus showed better 2-diphenyl-1-picryl-hydrazyl (DPPH), scavenging activity than P. tetragonolobus with IC50 values of 174.380 and 262.313, respectively, as compared to that of the standard, ascorbic acid, IC50 value of which being 111.16. The FRAP assay results for both the plants indicated that the methanol fractions showed closer results when compared with standards, ascorbic acid and quercetin. The IC50 value of S. indicus, P tetragonolobus, ascorbic acid, and quercetin was 70.065, 151.953, 85.162, and 79.647, respectively. These results clearly indicate that S. indicus methanol fraction had better antioxidant activity when compared to both standards.Conclusion: It is concluded that S. indicus and P. tetragonolobus have excellent antioxidant activities which could be the major contributing factors for their medicinal roles. Further studies in this direction are being carried on.
CHEMICAL COMPOSITION, ANTIMICROBIAL, AND ANTIOXIDANT ACTIVITIES OF TWO MOROCCAN THYMUS ESSENTIAL OILS
Authors: Aouam Imane , El Atki Yassine , Taroq Amal , El Kamari Fatima , Abdellaoui Abdelfattah
Published: January 2019

Objective: The aim of the present study is to investigate chemical constituents of Thymus riatarum and Thymus blecherianus essential oils (EOs) as well as to evaluate, for the first time, their antioxidant effect and antibacterial activity against six bacterial strains responsible for nosocomial infections.Methods: The chemical composition of EOs was analyzed using gas chromatography (GC) and GC-mass spectrometry, the antibacterial capacity of the two thymus species was evaluated against six bacteria species: Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Acinetobacter baumannii, and Citrobacter sp. using disk diffusion method and microdilution assay. Finally, the antioxidant activity was measured by four different test systems of assay, namely free radical scavenging activities, ferric reducing/antioxidant power assays, total phenolic, and flavonoid contents.Results: A total of 15 compounds representing 99.6% of T. riatarum oil were identified with thymol (28.8%), borneol (20.0%), and α-phellandrene (13.0%) as the main constituents. Eleven components of T. blecherianus were identified representing 98.2% of the total oil composition; the most abundant constituents were as follows: Carvacrol (45.9%), bornyl acetate (20.1%), and borneol (15.7%). Strong antibacterial activity of the two EOs was identified against all bacterial strains tested. Concerning the antioxidant results, T. riatarum EO exhibited higher antioxidant activity than T. blecherianus in the three assays with an IC50 value equal to 5.75±0.06 mg/ml, which was probably due to its high content of polyphenols (28.95±0.13 mg GAE/g DW). Total flavonoid content was found equal for the two EOs.Conclusion: EO of T. riatarum and T. blecherianus from Morocco can be exploited as a natural antibacterial and antioxidant new potential sources.
PHYTOCHEMICAL, MICROBIOLOGICAL, AND TECHNOLOGICAL STUDIES IN THE FIELD OF OBTAINING A HYDROALCOHOLIC EXTRACT WITH ANTIMICROBIAL ACTIVITY FROM THE LIQUORICE ROOT
Authors: Boyko Nikolay , Tkachev Alexandr , Kovalenko Anatoliy , Pisarev Dmitriy , Kuznietsova Victoria , Sushchuk Natalia , Bondarev Alexandr
Published: January 2019

Objective: The objective of this work was to carry out studies in the field of development of a hydroalcoholic extract from the liquorice root that has a high level of antimicrobial activity.Methods: For the antibacterial study of extracts, we have used the agar well diffusion method. In our research, we have utilized six test-strain microorganisms: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Proteus vulgaris ATCC 4636, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 885/653, and Bacillus subtilis ATCC 6633. Authors have applied vector theory for antimicrobial activity comparison of liquorice root extracts.Results: Phytochemical composition and antimicrobial activity of hydroalcoholic extracts from the liquorice root with the use of different concentrations of ethanol have been studied. The optimal range of ethanol concentration of 65±15% v/v has been found. The dependency between the integral index of antimicrobial activity of the extract and concentration of glycyram and licuroside has been found. The minimal concentration of glycyram and licuroside in the extract has been calculated for an exhibition of the target level of extract’s antimicrobial activity, which is 1.0 and 0.11% w/v, respectively.Conclusion: It has been found that the concentration of licuroside has greater influence on the integral index of extract’s antimicrobial activity in comparison with that one of glycyram. A highly effective technology for obtaining an extract with target phytochemical parameters has been suggested.
Relación de los factores de riesgo y comorbilidad en el programa de prevención de caídas en usuarios hospitalizados en un hospital psiquiátrico del sector salud.
Authors: Gallegos Sánchez Susana , Aguilar Rodríguez María Magdalena , Camarillo Ruíz María Navora
Published: January 2019

Introducción: Los pacientes hospitalizados en una unidad de salud mental tienen el riesgo potencial de enfrentar factores de riesgo. Con la intensión de prevenir caídas en los usuarios hospitalizados Ruelas y Sarabia (10, 11), han elaborado, un modelo de valoración de los factores de riesgo como son: falta iluminación adecuada, desorden del mobiliario, falta de limpieza del área física, desconocimiento de las medidas de seguridad dentro de las instalaciones de la unidad, así como factores inherentes al paciente y su condición como son: sexo, edad, estilo de vida, movilidad, factores relacionados con el estado físico, sensoriales, estado neurológico y emocional alterados, tratamiento farmacológico y los relacionados con los dispositivos para deambular. Material y Método: Se realizó una investigación de tipo transversal y descriptiva, de Mayo del 2008 a Mayo del 2009, la muestra la conformaron 285 pacientes hospitalizados a los cuales se les aplicó una cédula de evaluación de riesgo de caídas al ingreso y cada 7 días hasta su egreso. Resultados: Durante el tiempo de hospitalización 5% de los pacientes presentaron caída, entre las características de estos tenemos el ser mujer 76%, recibir tratamiento con benzodiacepinas (clonazepan) 100%, con diagnóstico de ingreso episodios depresivos graves con pensamiento o intento suicida 53%, con conducta disruptiva, por episodio maniaco o trastorno psicótico 38%, con reporte de resonancia magnética de pérdida de volumen de parénquima cerebral 61% y factores extrínsecos 28%. Conclusión: Se identificó que los factores de riesgo predominantes en nuestros pacientes son la combinación de psicofármacos, y la enfermedad mental, la falta de identificación del riesgo en pacientes, familiares, cuidadores y equipo de salud. En menor porcentaje influyen los factores estructurales.
Valoración de cualidades físicas en mujeres adultas antes y después de un programa de ejercicio físico
Authors: Huerta Barrrera Luz Nayeli , Ruiz Padilla Beatriz , Rodriguez Gutierrez Maria Cristina
Published: January 2019

Introducción: Las cualidades físicas en la vida cotidiana son la expresión de numerosas funciones corporales, la pérdida progresiva de estas, constituye un problema de salud debido al deterioro del estado funcional de la persona modificando su calidad de vida, es necesario fomentar el buen estado de salud para poder llegar a edades más avanzadas de la vida con un mantenimiento y/o mejoramiento de las cualidades físicas para disfrutar plenamente la vida. Objetivo: Conocer los cambios en las cualidades físicas de mujeres adultas sedentarias evaluándolas comparativamente al inicio y término de un programa de entrenamiento físico. Metodología: Diseño del estudio prospectivo, longitudinal y comparativo, la población de estudio fue de mujeres de 45 a 60 años de edad, sedentarias, la muestra se constituyo a conveniencia con 47 mujeres que terminaron el programa de entrenamiento físico, las cualidades físicas se evaluaron antes y después de un programa de ejercicio físico. Para conocer el comportamiento de la muestra se obtuvieron medidas de tendencia central, dispersión y pruebas de correlación. Resultados: En la primera valoración las cualidades físicas que se encontraban con un mayor nivel de deficiencia fueron la fuerza (92%), flexoelasticidad de cadera (93%) y flexoelasticidad de mano (66%), al realizar la segunda valoración las cualidades físicas que alcanzando en promedio un incremento significativo estadísticamente fueron la fuerza con 1.2 Kg, la velocidad de reacción visual con 1.1 mseg, la flexoelasticidad de tronco con 3.6 cm y la flexoelasticidad de mano con 0.9 cm. Discusión: Coincidimos con Sánchez Pinilla en lo referente a que la capacidad para mejorar las cualidades físicas dependerá de la cantidad de trabajo y tipo de ejercicio físico especifico para cada una de ellas, lo cual pudo haber contribuido a una mejora más significativa de las cualidades físicas. Conclusiones: De acuerdo con los resultados el presente estudio es una herramienta que puede ser empleada para analizar los efectos del ejerciciofísico sobre las cualidades físicas.
Hospital Magnético, ¿qué es y cómo funciona?
Authors: Domínguez Sánchez Patricia , Zarate Grajales Rosa A. , Serrano Diosdado José Juan , Arroyo Merino Miguel
Published: January 2019

Introducción : En el presente documento se aborda la importancia de conocer modelos de atención hospitalaria conocidos como magnéticos, en donde se logra la calidad del cuidado de enfermería y la satisfacción laboral entre otros factores, que se traduce en beneficios para los pacientes, el personal de enfermería y las instituciones. Desarrollo: Se revisan los antecedentes de los hospitales magnéticos, los elementos que se han identificado como esenciales para proporcionar cuidados de calidad de enfermería. Así como los factores que se han relacionado con este tipo de modelo de atención, que ponen de manifiesto. La importancia del rol del personal de enfermería en la atención de los pacientes y los resultados para las organizaciones. Conclusiones: Es necesario conocer estos modelos de atención en nuestro país, generando líneas de investigación que pongan de manifiesto la importancia que tiene contar con elementos necesarios para generar ambientes y entornos seguros y saludables de trabajo.
El espíritu de servicio y los valores éticos de enfermería
Authors: Sánchez Estrada Teresa , Vadillo B. Guadalupe , Benítez Fernando , Monterrosas Rosario
Published: January 2019

El estudio tuvo como Objetivo: la identificación de los valores éticos y de espíritu de servicio que aplica el personal de enfermería en un servicio clínico. Metodología: Se hizo un estudio descriptivo observacional y transversal, en una institución de segundo nivel de atención con 340 enfermeras adscritas, de las que 100 contestaron un formulario autoaplicable (emedic-1 con un alpha de Crombach de 0.915) de 26 ítems; entregado al inicio del turno y recogido, a través de las jefes de piso, al término de la jornada. La información se reporta en frecuencias relativas decrecientes. Las hipótesis direccionales plantean que: a) El nivel de espíritu de servicio en  la muestra estudiada calificará como alto (siempre o en más del 80% de los casos) medio (casi siempre o entre el 60 y 79% de los casos ) o bajo (raras veces o menos del 59% de los casos) según la escala emedic-1; b) los valores éticos inherentes al cuidado enfermero como la humildad, prudencia y discreción se encontrarán en un nivel alto (siempre o en más del 80% de los casos) según la escala emedic -1. Resultados:  muestran que cuatro de los siete valores éticos calificaron alto, es decir se aplican siempre. En orden decreciente tuvieron el siguiente comportamiento: la prudencia, honestidad, fiabilidad, gentileza y discreción, diligencia, humildad, y veracidad en las notas clínicas. En cuanto a espíritu de servicio sólo dos de los 17 indicadores sobre el espíritu de servicio cayeron en calificación alta éstos son: el llamar al paciente por su nombre y evitar el trato frío e indiferente. Obtuvieron calificación media: la realización de procedimientos conforme a principios científicos y éticos, y el buen talante. Tres indicadores del espíritu de servicio deficientes son la flexibilidad ante las peticiones del paciente, olvido del paciente por exceso de trabajo, y la dificultad para ofrecer un “plus” en el servicio. Conclusiones: Un elemento muy destacable es el relacionado con el número de expertos que se reportan dentro del grupo estudiado. Más de la tercera parte de las entrevistadas se asumen como expertas clínicas. Los indicadores del espíritu de servicio que caracterizan al personal de enfermería entrevistado se expresan de manera diferenciada. Uno de los atributos mejor calificados es definitivamente el que se dirigen al paciente por su nombre evitando el trato frío o indiferente aunque lo deseable es que estos dos atributos vayan “siempre” acompañados de un buen talante al realizar los procedimientos.
De la escuela al hogar; la formación de la enfermera visitadora
Authors: Agostoni Claudia
Published: January 2019

De la escuela al hogar; la formación de la enfermera visitadora.
Explicación kaldoriana del bajo crecimiento económico en México
Authors: Loría Díaz de Guzmán Eduardo Gilberto , Moreno-Brid Juan Carlos , Salas Emmanuel , Sánchez-Juárez Isaac
Published: January 2019

Con fundamento en la primera ley de Kaldor se ofrece una explicación sobre el bajo crecimiento económico de México en las últimas cuatro décadas. El texto parte de la hipótesis de que la falta de dinamismo de la producción total (no manufacturera) obedece a la insuficiente dinámica de las manufacturas y, particularmente, a que
el coeficiente de Kaldor se ha reducido con la liberalización comercial. Se realizaron
estimaciones (1980.1-2017.2) usando el método generalizado de momentos (GMM) y
rolling regression (estimaciones recursivas), lo que contribuye a solucionar el roblema
de autocorrelación serial y a tener una mejor apreciación estadística de la evolución de dicho coeficiente.
Organização do processo ensino-aprendizagem com o uso do smartphone na perspectiva da teoria da atividade de estudo
Authors: Paula Elson de , Resende Marilene Ribeiro
Published: January 2019

As tecnologias digitais estão presentes nas atividades diárias do homem contemporâneo, principalmente entre os jovens que as utilizam com destreza e naturalidade. Neste relato de experiência, apresenta-se parte dos resultados de uma pesquisa de mestrado que teve como objetivo organizar o processo ensino-aprendizagem com o uso do smartphone numa disciplina de um curso técnico integrado ao ensino médio, na perspectiva da Teoria da Atividade de Estudo de Davidov. Essa teoria está apoiada na Teoria Histórico-Cultural de Vigotski e na Teoria da Atividade de Leontiev. Utilizou-se a metodologia do experimento didático, uma intervenção pedagógica, que tem como objetivo promover aprendizagens e desenvolvimento do aluno. O experimento foi organizado em quatro atividades de estudo, realizadas em 18,5 horas, aproximadamente, num período de três meses. Os participantes foram 14 alunos, com idades de 16 e 17 anos. Foi possível constatar que há indícios de que o estudo organizado nessa perspectiva, usando o smartphone, despertou o querer aprender, promoveu a apropriação dos conceitos essenciais e dos processos técnicos da disciplina, desenvolvendo o pensamento teórico e promoveu a colaboração.
Metodologia do ensino superior com tecnologias da informação e comunicação: estratégias de ensino experienciadas
Authors: Mercado Luis Paulo Leopoldo , Gomes Maria Gisélia da Silva , Silva Carla Glycia Santos da
Published: January 2019

Este relato de experiência apresenta a investigação de metodologias educacionais com o uso das tecnologias da informação e comunicação (TIC) como ferramentas norteadoras no processo de promoção e inovação da qualidade do ensino superior. Descreve uma experiência envolvendo exploração de estratégias didáticas com recursos das TIC em aulas da disciplina “Metodologia do Ensino Superior com TIC”, ofertada aos mestrandos, doutorandos e discentes especiais do Programa de Pós-Graduação em Educação (PPGE) da Universidade Federal de Alagoas (UFAL), no segundo semestre do ano letivo de 2016. Apresenta o relato das atividades curriculares com utilização de TIC trabalhadas na disciplina, envolvendo a seleção de recursos tecnológicos, subsidiando aulas dinâmicas e colaborativas, em que o conhecimento a ser construído se deu de forma compartilhada num espaço interativo entre docente e estudantes. O referencial teórico é fundamentado em Masetto (1998), Debald (2003), Zabalza (2004), Mauri e Onrubia (2010) e Mercado (2015). Como resultados são descritas as estratégias metodológicas utilizadas durante o percurso da disciplina, mostrando possibilidades de práticas metodológicas para a promoção da qualidade e da inovação no que diz respeito à docência no ensino superior.
Ser pedagogo: a escolha profissional de egressos do curso de pedagogia
Authors: Lucindo Nilzilene Imaculada , Nunes Célia Maria Fernandes , Araújo Regina Magna Bonifácio de
Published: January 2019

Este artigo apresenta um recorte da pesquisa “Por onde andam os ex-alunos do curso de Pedagogia/UFOP? Conhecendo a trajetória e o lugar profissional desses egressos” que investigou a função profissional dos concluintes do curso de Pedagogia, formados após a implantação da Resolução CNE/CP nº 1/2006. O estudo, de abordagem qualitativa, fez uso da análise documental, da pesquisa bibliográfica e de campo. Na coleta de dados foi utilizado um questionário on-line destinado aos 145 egressos que se formaram entre 2012 e 2015. Identificamos que 75,7% dos egressos estão trabalhando; 72,9% atuam na área educacional; 51,4% em instituição pública. O fator que mais influenciou a escolha pela Pedagogia foi a identificação com a área e o ambiente educacional. Dos egressos, 70% se encontram satisfeitos com a profissão e 85,7% se declararam satisfeitos com sua escolha, contudo, as más condições e a precarização do trabalho docente são os fatores que justificam a insatisfação destacada por alguns.
struma ovarii maligno STRUMA OVARII MALIGNO ETAPA IIIC: REPORTE DE UN CASO Y REVISIÓN DE LA LITERATURA.
Authors: Narbona Yúsari Guillermo Enrique
Published: January 2019

RESUMENEl struma ovarii constituye una variable infrecuente dentro de los teratomas maduros del ovario. Menos del 5%tendrán una transformación maligna. En general no presentan síntomas, aunque existe un pequeño porcentaje depacientes que manifiestan un hipertiroidismo sincrónico.Si bien no existe un diagnóstico y tratamiento estandarizados, el pronóstico y la sobrevida suelen ser buenos.A continuación se presenta el caso de una paciente con diagnóstico incidental de tumor struma ovarii a la que serealiza cirugía de etapificación, donde se evidencian siembras peritoneales. Se decide a su vez realizar tiroidectomíaprofiláctica, terapia con radio yodo y quimioterapia adyuvante.Este tipo de aproximación – manejo quirúrgico agresivo sumado a terapia adyuvante con radio yodo – se perfilacomo lo más aceptado actualmente. Ante la necesidad de sumar reportes de casos exitosos en la literatura, se planteaeste caso clínico como un modelo de diagnóstico y tratamiento.Palabras Clave: Struma ovarii maligno, tumores germinales, teratoma, hipertiroidismo.
Validation of the Children’s Intrinsic Needs Satisfaction Scale among Canadian youth: psychometric properties,
criterion-related validity and multitrait multimethod
confirmatory factor analysis
Authors: Orpana Heather , Pearson Caryn , Dopko Raelyne L. , Kocum Lucie
Published: January 2019

Introduction

Based on self-determination theory, the Children’s Intrinsic Needs Satisfaction Scale (CINSS) measures autonomy, competence and relatedness at school, home and with peers. The factor structure and criterion-related validity of the CINSS in the Canadian youth population are tested using data from the Canadian Student Tobacco, Alcohol and Drugs Survey (CSTADS).

Methods

Data from the 2014/2015 CSTADS were analyzed for evidence of convergent and discriminant validity and for method variance. A multitrait multimethod (MTMM) confirmatory factor analysis (CFA) was conducted to account for the conceptual structure of the measure. Criterion-related validity was demonstrated through correlations between related constructs, prosocial behaviours and behavioural problems, and the CINSS subscale scores. Mean differences on CINSS subscale scores between those who reported and did not report being bullied or bullying others were also examined.

Results

Correlation analyses demonstrated that, in general, correlations were higher between concept/context item pairs and lowest between items measuring different concepts and contexts. Cronbach’s alpha for concept and context subscales were high: α = 0.77 for autonomy, α = 0.85 for competence and α = 0.79 for relatedness. A MTMM CFA demonstrated that the model fit the data well, with no modifications. Criterion-related validity was demonstrated through correlations between CINSS subscales and related concepts or mean differences on CINSS subscales between groups.

Conclusion

The CINSS demonstrates good internal consistency, factorial validity and criterion-related validity in this sample of Canadian students. The measurement of positive mental health among Canadian youth is central to surveillance efforts which will help inform mental health promotion activities across Canada.