bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunotherapy Using HistobulinTM In Psoriasis: A Case Report
Authors: Kim Hyuk Soon , Noh Geunwoong
Published: August 2021

Background: There is no cure for psoriasis. Early treatment using biologics is recommended to improve skin manifestations and reduce systemic inflammation, which leads to comorbidities in various organs.Case Presentation: HistobulinTM therapy was performed on a psoriasis patient who developed the disorder due to allergic rhinitis. Psoriasis was confirmed pathologically by skin biopsy. The patient responded rapidly, and the skin manifestations began to improve after just the first injection. Although the patient showed some temporary aggravation after the third injection, the clinical symptoms and signs improved continuously thereafter and disappeared after the eighth injection. Remission was induced and was evident when the patient showed no symptoms and signs during the subsequent 4 weeks during which time the patient received 4 more injections; afterwards, HistobulinTM therapy was ceased. After treatment, psoriasis did not recur for more than 6 months.Conclusions: HistobulinTM is effective and induces remission in psoriasis patients. HistobulinTM is suggested for curative therapeutics in psoriasis patients, and further basic research and clinical evaluation are necessary.
Ecological-niche modeling of genetically distinct populations revealed Kersting’s groundnut [Macrotyloma geocarpum (Harms) Maréchal et Baudet] as a resilient orphan crop to present and future climates
Authors: Coulibaly Mariam , Idohou Rodrigue , Akohoue Félicien , Peterson Andrew Townsend , Sawadogo Mahamadou , Achigan-Dako Enoch Gbenato
Published: August 2021

Orphan legume crops play an important role in smallholder farmers’ food systems. Though less documented, they have the potential to contribute to adequate nutrition in vulnerable communities. Unfortunately, data are scarce about the potential of those crops to withstand current and future climate variations. Using Macrotyloma geocarpum as an example, we used genetically informed ecological niche models to explore the role of ecology on the current and future distributions of genetic populations of Kersting’s groundnut. Three main conclusions emerged: i) the models had good predictive power, indicating that M. geocarpum’s distribution was correlated with both climatic and soil layers; ii) identity and similarity tests revealed that the two genetic groups while overlapping, are each, locally adapted and display differences in climate suitability; iii) by integrating the genetic information in niche modeling, niches projections show divergence in the response of the species and genetic populations to ongoing climate change. This study highlights the importance of incorporating genetic data into ENM approaches to obtain a finer information of species’ future distribution, and explores the implications for agricultural adaptation, with a particular focus on identifying priority actions in orphan crops conservation and breeding.
Taxonomic and Functional Composition of Soil Mycobiome of Two Agricultural Sites in Khartoum State, Sudan
Authors: Elnaiem Marwa H. E. , Taniguchi Takeshi , Siddig Marmar El
Published: August 2021

Fungi are one of the most diverse groups of organisms and considered as one of the least-explored biodiversity resources. Soil fungal community was investigated in two agricultural sites in Khartoum state, Sudan, during two seasons. A total of 42 soil samples were collected, their physicochemical properties were determined, then subjected to metabarcoding and metagenomic analyses. fungal community composition, diversity and microbial trophic modes were determined utilizing R software packages. From both sites, a total of 15 different phyla were detected, out of them, 11 were the most abundant and frequent. Ascomycota was the dominant phylum (86.54% total abundance), followed by the Basidiomycota (8.29%). The dominant class was Sordariomycetes (41.02%), followed by Dothideomycetes (19.80%). Aspergillus (6.2%), Curvularia (6.0%), Neurospora (5.8%) and Fusarium (4.9%) were the most abundant genera. Deniquelata for the first time being recorded in Sudan. Apha diversity measures revealed sample richness ranging from 71 to 361 ASVs, and Shannon index ranging from 2.794 to 5.087. The two sites had significantly different alpha diversity. Land-use types were also significantly different in their diversity regardless of site. Season had no effect on alpha diversity of soil fungal communities. Beta diversity analysis indicated significant differences between the two sites and the different land-use types. No significant differences in the community structure recorded between the two seasons. The dominant trophic mode among the assigned ASVs in soil mycobiome was saprotroph mode (22.11%). Results of this study reveals that fungal community structure is affected by site and land-use type. It gives a comprehensive database for the mycobiome of the agricultural soil in Khartoum state.
Deletions of the Plasmodium falciparum pfhrp2 and pfhrp3 genes among patients enrolled at six locations in the DRC: 2017–2018
Authors: McCaffery Jessica N. , Nace Douglas , Herman Camelia , Singh Balwan , Sompwe Eric Mukomena , Nkoli Papy Mandoko , Ngoyi Dieudonné Mumba , Kahunu Gauthier Mesia , Halsey Eric S. , Rogier Eric
Published: August 2021

Background: Rapid diagnostic tests (RDTs) detecting histidine-rich protein 2 (HRP2) and HRP3 are widely used throughout sub-Saharan Africa (SSA) to diagnose Plasmodium falciparum malaria. However, multiple SSA countries have reported pfhrp2 and pfhrp3 (pfhrp2/3) gene deletions. Methods: Blood samples (n=1109) collected from patients with P. falciparum infection from six health facilities throughout the Democratic Republic of the Congo (DRC) from March 2017 to January 2018 were evaluated for pfhrp2/3 deletions. Samples were assayed for HRP2, pan-Plasmodium LDH (pLDH) and aldolase (pAldolase) antigens by bead-based multiplex antigen assay. Samples with low HRP2 concentration compared to pLDH and pAldolase antigens were selected for further pfhrp2/3 genotyping PCRs.Results: The majority of blood samples (93.3%, 1035/1109) had high concentrations of the HRP2 antigen. Single deletions of pfhrp2 were identified in 0.27% (3/1109) of screened samples, with one sample from each of the Kapolowe, Mikalayi, and Rutshuru study sites. A pfhrp3 single deletion (0.09%, 1/1109) was found in the Kapolowe site. Dual pfhrp2 and pfhrp3 deletions were not observed. Conclusions: Due to, the low numbers of pfhrp2 deletions and the sporadic locations of these deletions, the use of HRP2-based RDTs appears to still be appropriate for these locations in DRC.
Inborn Errors of Immunity on the Island of Ireland – A Cross-Jurisdictional UKPID/ESID Registry Report
Authors: Ryan Paul , Redenbaugh Vyanka , McGucken Jayne , Kindle Gerhard , Devlin Lisa , Coulter Tanya , Buckland Matthew , Seppänen Mikko , Conlon Niall , Feighery Conleth , Edgar David
Published: August 2021

The epidemiology of inborn errors of immunity (IEI) in the Republic of Ireland was first published in 2005 but has not been updated since. IEI prevalence data from Northern Ireland was last published in 2018. Using data from the United Kingdom Primary Immune Deficiency (UKPID) and European Society for Immunodeficiencies (ESID) registries, we reviewed all registered cases of IEI affecting adult patients ≥18 years of age from the two largest immunology specialist centres in Northern Ireland and the Republic of Ireland respectively, and calculated the combined minimum adult prevalence of IEI on the island of Ireland for the first time. We also recorded data pertaining to presenting symptoms of IEI, diagnostic delay, immunoglobulin data, and genetic testing, as well as briefly reporting data pertaining to secondary immunodeficiency in both countries. We identified a minimum adult IEI prevalence in Ireland of 8.85/100,000 population (1:11,299).
NURBS Interpolator With Pre-compensation Based on Discrete Inverse Transfer Function for CNC High-precision Machining
Authors: Wang Taiyong , Cao Libo , Zhang Yongbin , Dong Jingchuan , Jia Songhui , Tian Chong , Liu Qingjian
Published: August 2021

In the field of CNC machining, high-speed and high-precision machining has been regarded as the key research by many scholars. In conventional methods, high-speed machining and high-precision machining are contradictory. It is inevitable to reduce the feedrate to improve the processing accuracy. In the paper, a pre-compensation based on discrete inverse transfer function (PDIT) theory is proposed. PDIT is able to improve machining accuracy by reducing contour errors without decreasing feedrate. The proposed PDIT theory is divided into three parts, NURBS interpolator, feedrate scheduling, and interpolator with pre-compensation. The NURBS interpolator has greatly advantage to interpolate the parameter curve directly. Therefore, the paper adopts the NURBS interpolator to accomplish interpolation. In the feedrate scheduling, S-type flexible acceleration and deceleration are used for path planning, and the maximum starting feedrate is obtained with the feedrate constraint. In the interpolator with pre-compensation, the NURBS interpolator is pre-compensated by PDIT. For inputs, the response of transfer function reach steady-state response with a little time. Before reaching steady-state response, the unsteady response exists in the transfer function. The unsteady response usually sustains tens of interpolation periods and must be lead contour error in machining. Hence, the PDIT theory is employed to compensate the contour error causing by the unsteady response of transfer function to NURBS interpolator. The drive system is a transfer function, so the unsteady response of drive system cause machining errors before reaching the steady-state response. In the paper, the NURBS interpolator is pre-compensated by PDIT theory before the drive system to reduce contour errors and improve machining accuracy. Finally, the performance of the proposed PDIT is evaluated by simulation experiments. The experimental results illustrate that PDIT theory obviously improve the machining accuracy and reduces the contour error.
3 Liter Polyethylene Glycol is Not Inferior to The Standard Bowel Preparation in Chinese Population with Equal Efficacy: A Randomized, Controlled Trial
Authors: Cheng Peng , Chen Qing-qi , Li Ju-yuan , Cheng Zheng , Guo Dian-hua , Zhong Zheng-rong , Bai Yu , Meng Xiangjun , Li Zhao-Shen
Published: August 2021

Background

Ideal bowel cleansing regimens should be both effective and well tolerated. The European Society of Gastrointestinal Endoscopy recommends 4L Polyethylene Glycol (PEG) as the standard regimen for the bowel preparation (BP). This large volume of PEG ensures a better-quality bowel cleansing but might be poorly tolerated amongst the Chinese population given their different characteristics. The current study compared the 3L and 4L PEG with regard to their effectiveness, tolerability, and safety amongst Chinese patients to identify the better suitable bowel cleansing method for this population.
Methods

This study employed a prospective, observer-blinded, randomized and controlled design in a high-volume endoscopic center. Consecutive patients undergoing colonoscopy were randomly assigned (1:1) to the 3L-PEG or 4L-PEG group. The quality of bowel cleansing, procedure time, adenoma detection rate (ADR), patient tolerance, and adverse events were compared.
Results

A total of 330 patients were included in the study. The quality of the bowel cleansing (Boston Bowel Preparation Scale) for both the whole intestine and each segment showing no significant differences between the groups. No significant differences were present with regard to the procedure time or ADR. The incidences of adverse events such as nausea (P = 0.001) and bloating (P < 0.001)were significantly lower in the 3L-PEG group. Moreover, there was a significantly higher rate of satisfaction in 3L-PEG group than that of the 4L-PEG group (P = 0.009).
Conclusions

3L-PEG bowel cleansing represents an optimal alternative to a 4L-PEG preparation for Chinese people, showing a similar efficacy and superior levels of satisfaction, acceptability, and safety amongst users. We recommend 3L PEG be the routine regimen in the clinical setting for Chinese patients. (ClinicalTrials.gov registration number: NCT03356015, registered in 29 November, 2017, https://www.clinicaltrials.gov/ct2/show/NCT03356015)
Barriers in Advance Care Planning and Goals of Care Discussion With Oncology Patients: The Perspective of Brazilian Medical Residents
Authors: Dias Laiane Moraes , Frutig Mayra Almeida , Bezerra Mirella Rebello , Barra Williams Fernandes , Castro Luísa , Rego Francisca
Published: August 2021

Background. Advance care planning (ACP) and goals of care discussions involve the exploration of what is most important to a person to prepare for health-care decision-making. Despite their well-established benefits, they are still not frequently performed in clinical oncology practice. The awareness of physicians’ barriers enables the development of tailored interventions to improve professional practice. Considering the scarcity of studies about the difficulties of medical residents in discussing goals of care, this study aims to determine, from the perspective of medical residents, the barriers to the discussion goals of care and ACP with patients with cancer. Methods. A previously published survey (Decide-Oncology) to assess barriers to goals of care discussion among health care providers was adapted to Portuguese language and distributed to Brazilian medical residents from three hospitals in Brazil in a cross-sectional pilot study. Residents were asked to rank the importance of various barriers to discuss goals of care (ranging from 1-extremely unimportant to 7-extremely important). Results: Twenty-nine residents answered the questionnaire (30.9%). The most reported barriers were related to patients and their families' difficulty in understanding and accepting the diagnostic and the prognosis, patients’ desire to receive full active treatment and the lack of an advance directive. Furthermore, the physician and external factors such as lack of training and lack of time to have these conversations were also very important barriers. The identification of the key barriers that limit the discussion of ACP and early palliative care referrals can certainly help to prioritize the next steps for future studies aimed at improving ACP and goals of care discussions.
Detection of the Sentinel Lymph Node With Hybrid Tracer (ICG-[99mTc]Tc-albumin Nanocolloid) in Intermediate and High Risk Endometrial Cancer. A Feasibility Study
Authors: Izquierdo Nuria Sánchez , Vidal-Sicart Sergi , Campos Francisco , Torné Aureli , Angeles Martina Aida , Migliorelli Federico , Munmany Meritxell , Saco Adela , Diaz-Feijoo Berta , Glickman Ariel , Ordi Jaume , Perissinotti Andrés , Pino Marta del , Paredes Pilar
Published: August 2021

Purpose: Indocyanine green (ICG) is frequently used for the detection of the sentinel lymph node (SLN) in gynecology, but it carries the loss of the presurgical SLN mapping provided by [99mTc]-based colloids. Hybrid tracers such as ICG-[99mTc] Tc-albumin nanocolloid combine the benefits of both components. The aim of this study was to evaluate the feasibility and applicability of this hybrid tracer injected by transvaginal ultrasound-guided myometrial injection of radiotracer (TUMIR) approach in the detection of SLNs in patients with intermediate- and high-risk EC. Methods: Fifty-two patients with intermediate- and high-risk EC underwent SLN biopsy after injection of a hybrid tracer using the TUMIR approach, followed by pelvic and paraaortic lymphadenectomy. SLNs were detected preoperatively by lymphoscintigraphic study and intraoperatively by gamma probe and near-infrared (NIR) optical laparoscopic camera. Results: Preoperative lymphatic drainage was obtained in 69% and intraoperative detection in 71.4% of patients. A total of 146 SLNs (4.17 SLNs/patient) were biopsied. Pelvic bilateral detection was observed in 57% of the women and paraaortic drainage in 34% of the patients. The radioactive component allowed the detection of SLN in 97.1% of the patients, while the fluorescent component detected 80%. In more than 17% of the patients with intraoperative detection, SLNs were detected only by the radioactive signal. Lymph node metastasis were identified in 14.3% of patients submitted to SLNB. The sensitivity and negative predictive value for metastatic involvement were 100%. Conclusion: TUMIR injection of a hybrid tracer in patients with intermediate- and high- risk EC combines the benefits of the radiotracer and the fluorescence methods with a single tracer. The method increases the paraaortic detection rate and allows a potential increase in SLN detection. Notwithstanding, based on our findings, the radioactive component of the hybrid tracer cannot be obviated.
Efficacy of TSPO ligands on neuronal damage mediated by LPS-stimulated BV-2 microglial activation
Authors: ma baoyu , Liu Yongxin , Zhang Xiao , Zhang Rui , Zhang Zhenjiang , Zhang Zhihao , Liu Jie , Juan Zhaodong , Sun Xiaotong , Sun Lina , Feng Jinpeng
Published: August 2021

Background

Neuroinflammation mediated by microglia is an important pathological process of neurodegenerative diseases. Alleviating the inflammatory response caused by activated microglia might be a valuable treatment. The 18-kDa translocator protein (TSPO), as a marker of neuroinflammation, is significantly elevated in activated microglia. But the function of TSPO in microglia has not been well demonstrated.
Methods

In this study, we evaluated the role of TSPO and its ligands in LPS-activated BV-2 microglia involving mitophagy pathway and the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation. Then, in the microglia-neuron co-culture system, the neurotoxicity induced by LPS-activated microglia and the neuroprotective effects of TSPO ligands were evaluated.
Results

Our results showed that after stimulated by LPS, TSPO expression was increased, meanwhile the expression of autophagy associated proteins were decreased in BV-2 microglia cells, but the reduction was reversed by pretreatment with PK11195 and Midazolam. Simultaneously, the NLRP3 inflammasome were increased in LPS activated BV-2 microglia in Transwell co-culture system, pretreatment with TSPO ligands could curb this undesirable situation. Furthermore, TSPO ligands improved the cell viability and reduced apoptosis of neuronal cells in co-culture system.
Conclusions

TSPO ligands PK11195 and Midazolam showed neuroprotective effects by reducing the inflammatory response of LPS-activated microglia, which may be related to the enhancement of mitophagy and the inhibition of NLRP3 inflammasome.
Association Between Antibiotics Use and Diabetes Incidence: A Nationally Representative Cohort Among Koreans
Authors: Park Sun Jae , Park Young Jun , Chang Jooyoung , Choi Seulggie , Lee Gyeongsil , Son Joung Sik , Kim Kyaehyung , Oh Yunhwan , Park Sang Min
Published: August 2021

Background Previous studies have reported that antibiotics could lead to diabetes, even after adjusting for confounding variables. This study aimed to determine the association between antibiotic use and diabetes incidence in a nationally representative cohort.MethodsThis retrospective cohort study included adults aged 40 years or older who were enrolled in the Korean National Health Insurance Service-Health Screening Cohort. (NHIS-HEALS). Antibiotic exposure was assessed from 2002 to 2005 and newly diagnosed diabetes mellitus was determined based on diagnostic codes and history of antidiabetic medication use from 2006 to 2015. Multivariate Cox proportional hazards model was used to assess the association between antibiotic use and diabetes incidence.ResultsThe mean age of the 201,459 study subjects was 53.2 years. People who used antibiotics for 90 or more days had a higher risk of diabetes (adjusted hazard ratio [aHR] 1.16, 95% confidence interval [CI] 1.07–1.26) compared to non-users. Those who used five or more classes of antibiotics had a higher risk of diabetes than those who used one antibiotic class (aHR 1.14; 95% CI 1.06–1.23). ConclusionThe clear dose-dependent association between antibiotics and diabetes incidence emphasized the need for antibiotic stewardship and judicious prescription of antibiotics.
Exercise Preconditioning to Improve Myocardial Ischemia Tolerance Via the NO-PKC-KATP Signaling Pathway
Authors: Peng Fenglin , Gan Chunlong , Liu Ting , Lv YuHu
Published: August 2021

Background: Exercise preconditioning (EP) has a similar effect on ischemic preconditioning. Yet the specific endogenous trigger substance, intermediary substance and effect substance involved in EP have yet to be fully defined.Methods: 32 SD rats were divided into four groups: group A (control sham operation group); group B (control ischemia/reperfusion (I/R) model group); group C (train and I/R model group); and group D (train, inhibitor, and I/R model group). Rat model of acute endurance exercise was established. Then, in vivo I/R experiment and index test of the serum myocardial enzymes, the heart functions, Kir6.1 and Kir6.2 gene expressions and NOS and PKC protein expressions were carried out.Results: Compared with the A group, the heart function of the B group decreased significantly, and the serum myocardial enzymes increased significantly. Compared with the B group, the C group had less heart function decline and less myocardial injury. Injection L-NAME attenuated the cardioprotection induced by exercise preconditioning. B group's PKC protein expression was higher than the A group's; the C group's PKC protein expression was significantly higher than the B group's, and the D group's PKC protein expression was significantly lower than the C group's. In addition, the B group's Kir6.1 and Kir6.2 gene expressions were higher than the A group's; the C group's Kir6.1 and Kir6.2 gene expressions were significantly higher than the B group's, and the D group's Kir6.1 and Kir6.2 gene expressions were significantly lower than the C group's.Conclusions: Moderate intensity endurance exercise can induce a cardioprotective effect on I/R myocardium. Exercise preconditioning induces myocardial protective function via the NO-PKC-KATP signaling pathway.
Pandemic Metric with Confidence (PMC) Model to Predict Trustworthy Probability of Utilized COVID-19 Pandemic Trajectory across the Global
Authors: Zuo Zhengkang , Yan Lei , Zhao Hongying
Published: August 2021

Lots of works aim to reveal the driving factors of COVID-19 pandemic trajectory yet ignore the confidence of utilized trajectory data, making consequent results suspicious. Hereby, we proposed a pandemic metric with confidence (PMC) model in the hypothesis of Bernoulli Distribution of nine trajectories reported from 113 countries. Results exhibit the average confidence of trajectories across the global not in excess of 12.1% with the error threshold configuration of 1E-5. In contrast, the 95% high confidence setting also failed to predict the trajectory containing the acceptable error not beyond 1E-3. Thus, a proposed trade-off strategy between two contradictory expections (>50% confidence, <1E-3 error) supports 61% of investigated countries to predict the varying trajectory with confidence beyond 50%. Moreover, PMC model recommend the remanent 39% countries to extend the proportion of populaces in COVID-19 detecting-pool to a suggested-value (>1% of populations), ensuing the average confidence up to 70%.
Scalable generation of random graphs
Authors:   , Penschuck Manuel
Published: August 2021

Netzwerkmodelle spielen in verschiedenen Wissenschaftsdisziplinen eine wichtige Rolle und dienen unter anderem der Beschreibung realistischer Graphen. Sie werden häufig als Zufallsgraphen formuliert und stellen somit Wahrscheinlichkeitsverteilungen über Graphen dar. Meist ist die Verteilung dabei parametrisiert und ergibt sich implizit, etwa über eine randomisierten Konstruktionsvorschrift. Ein früher Vertreter ist das G(n,p) Modell, welches über allen ungerichteten Graphen mit n Knoten definiert ist und jede Kante unabhängig mit Wahrscheinlichkeit p erzeugt. Ein aus G(n,p) gezogener Graph hat jedoch kaum strukturelle Ähnlichkeiten zu Graphen, die zumeist in Anwendungen beobachtet werden. Daher sind populäre Modelle so gestaltet, dass sie mit hinreichend hoher Wahrscheinlichkeit gewünschte topologische Eigenschaften erzeugen. Beispielsweise ist es ein gängiges Ziel die nur unscharf definierte Klasse der sogenannten komplexen Netzwerke nachzubilden, der etwa viele soziale Netze zugeordnet werden. Unter anderem verfügen diese Graphen in der Regel über eine Gradverteilung mit schweren Rändern (heavy-tailed), einen kleinen Durchmesser, eine dominierende Zusammenhangskomponente, sowie über überdurchschnittlich dichte Teilbereiche, sogenannte Communities. Die Einsatzmöglichkeiten von Netzwerkmodellen gehen dabei weit über das ursprüngliche Ziel, beobachtete Effekte zu erklären, hinaus. Ein gängiger Anwendungsfall besteht darin, Daten systematisch zu produzieren. Solche Daten ermöglichen oder unterstützen experimentelle Untersuchungen, etwa zur empirischen Verifikation theoretischer Vorhersagen oder zur allgemeinen Bewertung von Algorithmen und Datenstrukturen. Hierbei ergeben sich insbesondere für große Probleminstanzen Vorteile gegenüber beobachteten Netzen. So sind massive Eingaben, die auf echten Daten beruhen, oft nicht in ausreichender Menge verfügbar, nur aufwendig zu beschaffen und zu verwalten, unterliegen rechtlichen Beschränkungen, oder sind von unklarer Qualität. In der vorliegenden Arbeit betrachten wir daher algorithmische Aspekte der Generierung massiver Zufallsgraphen. Um Anwendern Reproduzierbarkeit mit vorhandenen Studien zu ermöglichen, fokussieren wir uns hierbei zumeist auf getreue Implementierungen etablierter Netzwerkmodelle, etwa Preferential Attachment-Prozesse, LFR, simple Graphen mit vorgeschriebenen Gradsequenzen, oder Graphen mit hyperbolischer (o.Ä.) Einbettung. Zu diesem Zweck entwickeln wir praktisch sowie analytisch effiziente Generatoren. Unsere Algorithmen sind dabei jeweils auf ein geeignetes Maschinenmodell hin optimiert. Hierzu entwerfen wir etwa klassische sequentielle Generatoren für Registermaschinen, Algorithmen für das External Memory Model, und parallele Ansätze für verteilte oder Shared Memory-Maschinen auf CPUs, GPUs, und anderen Rechenbeschleunigern.
THE IMPACT OF COVID-19 ON MARKET CAPITAL ON THE EXAMPLE OF THE TOURIST INDUSTRY: EXPERIENCE OF THE EU AND OTHER COUNTRIES
Authors: Troian M. , Shkola V. , Domashenko M. , Makarenko T.
Published: August 2021

With the spread of the COVID-19 pandemic, the tourism industry faced a crisis that could be the worst in history. In recent years, the tourism industry has been one of the fastest-growing industries, sometimes faster than the world economy as a whole. 2019 has brought unprecedented changes to the world order, affecting all socio-ecological and economic ties. What are the consequences of and will have global tourism in connection with the spread of the COVID-19 pandemic, which countries and regions of the world will suffer the greatest losses, what threatens and what are the benefits of the tourism crisis that will bring a "new order" to the tourism industry, what innovative management anti-crisis measures should be applied by world governments and non-governmental organizations to overcome the unprecedented tourism crisis - all these issues remain acute and have identified the research topic. The paper examines the methodological developments and recommendations for overcoming the tourism crisis in Europe caused by the pandemic virus COVID-19, namely, the article identifies the basics and consequences of the pandemic impact on market capital on the example of tourism in Europe and the world, shows that the global tourism industry is one of the main factors in the formation of market capital, studied market capital as a component of intellectual capital on the example of tourism in the EU, outlined the prospects for global tourism, developed a system of measures to overcome the global crisis through tourism SWOT-analysis. Namely: enhanced multilateral cooperation and strong support are important for the resumption of tourism; the speed of adaptation of governments at all levels and the private sector involved in the tourism sector and the ability to respond quickly and adapt to the crisis; providing targeted and affordable government support as quickly and efficiently as possible for vulnerable tourism enterprises, workers and tourists; ensuring policy clarity and taking measures to limit uncertainty; invention and development of more sustainable and sustainable (socio-ecological-economic) models of tourism; development of tourism education and legislation.
Individual and Organisational Level Drivers and Barriers to Building Information Modelling
Authors:   Department of Architecture, Mimar Sinan Fine Arts University, Istanbul, TURKEY, Ademci Ensar , Gundes Selin ,   Department of Architecture, Mimar Sinan Fine Arts University, Istanbul, TURKEY
Published: August 2021

The diffusion of building information modelling (BIM) has remained slow and the search for a solution to the problems that prevent technology acceleration continues. Although, there is strong evidence that user resistance is a major factor in delaying the adoption of new technologies, little attention has been paid to the drivers of BIM use in literature. Besides, majority of the studies on organisational barriers focus on large firms, despite strong emphasis laid on increased collaboration in the BIM. In the current study, the drivers of and barriers to BIM adoption and implementation are explored at both individual and organisational levels through a survey conducted on 905 industry professionals from the Turkish construction industry. This study further explores differences between groups of firm size in embracing BIM technologies to assess the extent and presence of digital divide. Results reveal that professionals place more value on performance enhancing factors rather than social influence for the adoption of BIM, indicating the role of improved performance as a driver for BIM. The most prominent barriers, on the other hand, appear to be related to the availability of expertise and skills, a problem that seems to exist not solely within companies but also further down the supply chain. Policymakers seeking to disseminate BIM use may address these concerns and consider these insights to revise policies and incentives.
New Mineral Names,
Authors: Belakovskiy Dmitriy I. , Uvarova Yulia
Published: August 2021

In this issue

This New Mineral Names has entries for 11 new species, including 7 minerals of jahnsite group: jahnsite-(NaMnMg), jahnsite-(NaMnMn), jahnsite-(CaMnZn), jahnsite-(MnMnFe), jahnsite-(MnMnMg), jahnsite-(MnMnZn), and whiteite-(MnMnMg); lasnierite, manganflurlite (with a new data for flurlite), tewite, and wumuite.
Moderating effect of firm performance on firm value: Evidence from Indonesia
Authors: Nurhayati Ida , Sudiyatno Bambang , Puspitasari Elen , Basiya Robertus
Published: August 2021

The practice of accounting conservatism, determination of capital structure, and firm performance are important elements in influencing firm value, either directly or through moderation. Firm performance as a reflection of company`s policy plays an important role as a variable that can moderate this influence. Thus, this study aims to examine the role of firm performance in influencing firm value, particularly in moderating the effect of accounting conservatism and capital structure. To test this role, managerial ownership and institutional ownership are viewed as control variables. A total of 43 manufacturing companies from the Indonesia Stock Exchange (IDX) were sampled from 153 manufacturing companies listed from 2017 to 2019 to achieve this target. The data collection approach in this study was purposive sampling, and the data analysis method was multiple regression. The results showed a statistically significant positive effect between accounting conservatism and firm value, while the capital structure had no statistically significant effect. Firm performance acts as a moderating variable of accounting conservatism and capital structure in influencing firm value. The results of this study also confirm that managerial ownership and institutional ownership do not function as control variables in controlling the effect of accounting conservatism and capital structure on firm value. Whereas managerial and institutional ownership is expected to encourage managers to carry out policies that are oriented towards increasing the firm value.
AcknowledgmentThis paper is an independent study that is not funded by any institution. We would like to thank all those who have provided immaterial support for the implementation of this study.
Community Development within Local Wisdom Frame (The Case of Ki Ageng Tarub Cultural Kitrab, Tarub Village, Tawangharjo, Grobogan)
Authors: Fauzi Ahmad , Wahyuningsih Endang Sri , Khasanah Miatun
Published: August 2021

Local traditions and culture as a form of local wisdom serve as a medium to maintain and care for the harmony of the community environment. This includes harmony and unity between fellow communities when the community and nation environment is undermined by the dangers of intolerance, radicalism and terrorism. Local wisdom is one effective way to overcome it. One form of local wisdom that exists in the community is the tradition of the Ki Ageng Tarub Cultural Culture , the ancestor of the kings in Java. This research aims to reveal how the tradition of the Ki Ageng Tarub Cultural Culture can accommodate social relations between communities and even to the Surakarta palace. This research is a qualitative-exploratory, case study with an ethnographic approach and uses interactive analysis which includes data reduction, data presentation and conclusion drawing. It is hoped that in this research, it can be known about the intent, purpose and meaning of cultural culture as well as social cohesion in the frame of local wisdom in the tradition of Ki Ageng Tarub Cultural Culture.
FOREIGN LANGUAGES TEACHING METHODS: TEMPORAL VERB FORMS AND ADVERBIAL MODIFIERS OF TIME
Authors:   Peter the Great St. Petersburg Polytechnic University, Amakhina S.A. , Dmitrieva N.V. ,   Peter the Great St. Petersburg Polytechnic University
Published: August 2021

The article deals with temporal verb forms in the predicate position identified in functional syntax as syntaxemes. The aim of the article is to analyze temporal verb forms in their correlation with adverbial modifiers of time, the latter forming another group of syntaxemes with a particular syntactic meaning. The tasks of classifying temporal syntaxemes, establishing their oppositional series and studying their distribution characteristics are performed by using the comparative analysis and the method of experiment. According to the authors, the approach to study verb forms in their immediate syntactic environment results in arousing students' considerable interest and contributes to their better translation skills.
TO THE PROBLEM OF THE NOTIONAL CONTENT OF THE CONCEPT
Authors:   Astrakhan State University, GROKHOVSKAYA I.A.
Published: August 2021

The study of concepts can be considered one of the current directions in modern linguistics. This is evidenced by numerous theoretical studies of the concept, as well as a significant number of works devoted to describing specific concepts in different languages. This article discloses the notional content of the concept "robot," revealed by the analysis of Russian-speaking and English-speaking lexicographic sources.
TERMINOPATIYA: COACH
Authors:   Astrakhan State University, Kolokolova N.M.
Published: August 2021

The article analyzes the lexico-semantic meaning of the term of English origin coach and coaching, the frequency of its use in speech of the Russian-speaking society. A comparative analysis of the professional characteristics of the coach and the teacher, their working conditions and working methods is carried out. It is concluded that extrapolation of the concept of economic term to the sphere of general and higher education in Russia is irrelevant.
THE CONCEPTS “CONSCIENCE” AND “SHAME” IN THE RUSSIAN LANGUAGE
Authors:   Chechen State University, Mantsaeva A.N. , Chukuev A.A. ,   Chechen State University
Published: August 2021

The article discusses the concepts of “conscience” and “shame” in Russian as a whole. The selection of these concepts as an object of investigation consists in their significance, for they contain, close to us, meanings coexisting with the picture of the nation's world. The semantic content of the concepts “conscience” and “shame” was scrutinized through the prism of Russian sayings and proverbs, an analysis was made of the compatibility of the keyword and its associative relations.
DIFFICULTIES OF INTRODUCING PARONYMIC UNITS IN FOREIGN LANGUAGE TEACHING
Authors:   Bashkir State University, Motina O.P. , Titlova A.S. ,   Bashkir State University
Published: August 2021

The article reveals the difficulties concerning mixing cognate paronymic units in students studying a foreign language. The causes of the erroneous use of consonant words are considered and the examples of such false associations are given. Criteria of distinguishing between paronymy and related semasiological phenomena of homonymy, synonymy and antonymy are defined; this enables us to conclude the practicability of introducing paronyms semanticizing them through synonyms and antonyms.
PROFESSION OF RECORD MANAGER IN THE MODERN INFORMATION TECHNOLOGY ENVIRONMENT
Authors:   Immanuel Kant Baltic Federal University, Probst N.A. , Vaulina S.S. ,   Immanuel Kant Baltic Federal University
Published: August 2021

The article explores the current state and prospects of the profession of document science in Russia. It describes the requirements for a modern specialist in the field of records management and archives, as well as the quality of his / her training at a higher educational institution. The author identifies the reasons that determine the demand for this profession in the conditions of development of electronic document management tools.
MAIN CHARACTERISTICS OF TERMINOLOGICAL LEXIS AS A PART OF SCIENTIFIC PICTURE OF THE WORLD
Authors:   Chechen State University, Khakieva Z.U. , Edelbieva M.L. ,   Chechen State University
Published: August 2021

The purpose of the study is to describe the main characteristics of the terminological vocabulary. We consider such concepts as "terminological vocabulary", "Professional vocabulary", "Special vocabulary". The results obtained allowed to conclude that the terms form the core of special vocabulary. Under the term in this case it is understood as the verbal name of the concept relating to the terminology of the specific field of scientific and / or professional knowledge, and under the terminology - the system of terms denoting the concepts formed for a long time used in a specific technical or scientific sphere. The key requirements are defined and described key requirements: its semantic accuracy, the ability to call items and phenomena, definition, language expressiveness, modal neutrality, systemic in lexical and word-forming levels of the language, the ability to reflect only one property or a phenomenon within its own "terminological field".
THE CONCEPT OF CHRONOTOPE IN THE NOVEL “MRS DALLOWAY” BY V. WOOLF
Authors:   Kostroma State University, Makarova E.Yu.
Published: August 2021

This article deals with the concept of chronotope in the text of the novel "Mrs. Dalloway” by Virginia Woolf. Certain characteristics of chronotope exemplifying these concepts were selected and analyzed, the former serving as an integral part of the analysis of works of the modern era. As a result of a continuous sampling and subsequent analysis of the text of the novel, we concluded that despite the contrast of the characters from different social classes, they are united by a single spatio-temporal continuum regulated by the chronotope. Virginia Woolf managed to accurately and truthfully convey the atmosphere of 1923, as she was a direct witness to the events taking place in the country and the world at that time.
PARONYMY AND RELATED PHENOMENA OF SOUND SIMILARITY OF WORDS
Authors:   Bashkiria State University, MOTINA O.P.
Published: August 2021

The article raises the issue of erroneous and deliberate confusion of paronyms in speech. An attempt is made to disclose the relationship of paronymy with the phenomena of folk etymology, contamination, paronomasia and paronymic attraction. The analysis gives a more complete understanding of the functioning of paronymic units in speech.
COMMUNICATION AND INTERACTION IN THE INTERNET-MEDIATED ENVIRONMENT (PSYCHOLINGUISTIC APPROACH)
Authors:   Bashkiria State University, MOTINA O.P. , Titlova A.S. ,   Bashkiria State University
Published: August 2021

The article studies the basic differences between the concepts of interaction and communication. Unidirecrtional and bidirectional means of mass communication are considered. The classification of speech genres in respect of a mediatext is given.
ABOUT SOME PECULIARITIES OF PROFESSIONAL REQUIREMENTS TO THE LEVEL OF QUALIFICATION "CHEMISTRY" IN THE SYSTEM OF HIGHER EDUCATION
Authors:   Astrakhan State University, NASIKHANOVA A.Z.
Published: August 2021

This article examines skill requirements to the profession of a chemist. Special attention is paid to numerous areas of application of knowledge of chemistry, risks in professional activities as well as occupational standards. The result of this research is the conclusion that thanks to the activities of chemists, humanity is not only based on the knowledge that was obtained earlier but also receives new ones.
Efficacy and Safety of Lurasidone in Children and Adolescents: Recommendations for Clinical Management and Future Research
Authors: Amerio Andrea , Giacomini Costanza , Fusar-Poli Laura , Aguglia Andrea , Costanza Alessandra , Serafini Gianluca , Aguglia Eugenio , Amore Mario
Published: August 2021

Lurasidone is a novel azapirone derivative and atypical antipsychotic agent with a high binding affinity
for dopaminergic (D2), serotoninergic (5-HT2A), and 5-HT7 receptors (antagonist), a moderate affinity for 5-
HT1A receptors (partial agonist), and no appreciable affinity for histaminergic (H1) and muscarinic (M1) receptors.
It was recently included by the European Medication Agency among the in-label pharmacological treatments
for children and adolescents affected by early onset schizophrenia. As a dopamine and serotonin antagonist,
lurasidone acted on a variety of receptors and showed its efficacy both as an antipsychotic and an activating
compound. Administered with food or within 30 minutes from a meal, it presents sufficient bioavailability
and does not interact with most of the other drugs during metabolism. With little effects on hormones and
weight gain, potential procognitive profile due to its 5-HT7 antagonism, and reduced extrapyramidal side effects,
lurasidone could be a good choice in terms of both effectiveness and tolerability, particularly for patients
headed towards a long-term treatment. This article aims to summarize the available scientific evidence from the
literature on the use of lurasidone in children and adolescents and to provide recommendations for clinical
management and future research.
Rationale Design, Synthesis, and Pharmacological Evaluation of Isatin Analogues as Antiseizure Agents
Authors: Firke Sandip , Cheke Rameshwar , Ugale Vinod , Khadse Saurabh , Gagarani Manish , Bari Sanjay , Surana Sanjay
Published: August 2021

Background:

Epilepsy is one of the most common and devastating neurological diseases
affecting about 1% of the world’s population at any time. Herein, we have reported rationale design and
synthesis of 5-acetyl-3-((4-substitutedphenyl)imino)indolin-2-one analogues 3(a-k) as antiseizure
agents.

Objective:

These analogues were designed as four component pharmacophoric model by clubbing
structural fragments of potent antiepileptic drugs. The Aim of this study is to synthesize structurally
designed isatin analogues and screen them for anticonvulsant activity and neurotoxicity.

Methods:

The compound 3d have exhibited good anticonvulsant activity in preclinical seizure models
with better toxicity profile when compared to standard drugs (3d: ED50 = 31.5 mg/kg, MES test;
ED50 = 37.4 mg/kg, scPTZ test; TD50 = 384.3 mg/kg,). Compound 3d have also shown good binding
affinity at crucial amino acids of GluN1 subunit of NMDAR (Docking score = -9.30) and fit
adequately in the cavity of the receptor (Amino acids involved and H-bonding distance = GLY93:
acetyl >C=O, 2.38Å; PHE92: acetyl >C=O, 2.22Å; and THR26: >C=O of isatin, 1.71Å). Results of
molecular docking supported the structural features present over isatins to persuade potent
antiseizure activity.

Results:

The compound 3d have exhibited good anticonvulsant activity in preclinical seizure models
with better toxicity profile when compared to standard drugs (3d: ED50 = 31.5 mg/kg, MES test;
ED50 = 37.4 mg/kg, scPTZ test; TD50 = 384.3 mg/kg,). Compound 3d have also shown good binding
affinity at crucial amino acids of GluN1 subunit of NMDAR (Docking score = -9.30) and fit
adequately in the cavity of the receptor (Amino acids involved and H-bonding distance = GLY93:
acetyl >C=O, 2.38Å; PHE92: acetyl >C=O, 2.22Å; and THR26: >C=O of isatin, 1.71Å). Results of
molecular docking supported the structural features present over isatins to persuade potent
antiseizure activity.

Conclusion:

Rationale designing strategy, in-vivo pharmacological profile, and computational
studies make us anticipate the emergence of these molecules as novel antiseizure agents, which can
be further explored to develop probes for the treatment of epilepsy.
Criterios de éxito del emprendimiento femenino, desde la metodología de la cartografía social
Authors: Peña Ulloa Luz Yarime , Gamba Mora Yaneth Carolina , Acosta Cortes Luisa Fernanda
Published: August 2021

This article presents the criteria for the success of female entrepreneurial entrepreneurship in commune eight of the city of Villavicencio, based on the methodological elements of social cartography, such as: the territory, the participating actors, which constitute the unit of analysis and at work, relationships with other actors involved in the business exercise. The results of the participatory mapping and theoretical elements guide the formation of a baseline for the study on gender entrepreneurship, in order to make visible the successful experiences in a graphic way.
Homicidio por parte de conductores de vehículos automotores en estado de embriaguez
Authors: Palacios Rengifo Jhonfer , Rueda Sánchez Wendy Vanessa
Published: August 2021

The repeated and already common cases of deaths due to drunk drivers in the country have naturally generated a rejection of society, this because in most cases the consequences are catastrophic, since the victim almost always ends up with the affectation of one of the organs and / or extremities or in the worst case and how we can show in our daily living with the same death. Criminal law has not been oblivious to focusing its gaze on those factual assumptions, taking into account that, the punitive power of the State, in an attempt to safeguard the legal rights of its citizens, must intervene in circumstances in which there is injury or risk to good legally protected "LIFE AND PERSONAL INTEGRITY", specifically. The Supreme Court of Justice (process 32964 of 2010), after ruling on the punitive treatment that should be given to the perpetrators of said conduct, suggested an interpretation that for the judges, and dogmatists of criminal law, it has triggered all kinds of debates where we find supporters and detractors, loves and heartbreaks, in the sense that for some scholars of criminal dogma it is too broad an interpretation in which ambiguities may arise. In this writing we will carry out a clear and deep analysis in order to be able to answer what type of subjective imputation we consider to be attributed to a subject who commits a homicide while driving a motor vehicle while intoxicated.