bluuebunny/crossref_metadata_2025 huggingface dataset:
New 1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-2-phenylisoquinoline-1(2H)-ones
as Phosphoinositide 3-kinase Inhibitors for Treating Cancer and Other Diseases
Authors: De Surya K.
Published: February 2023

The patent describes novel useful compounds, such as PI3K protein kinase inhibitors, in
particular as PI3K delta (δ) and/or gamma (γ) protein kinase modulators. The present disclosure
also provides methods for preparing PI3K protein kinase inhibitors, pharmaceutical compositions
containing them, and methods of treatment, prevention, and amelioration of PI3K kinase-mediated
diseases, and disorders.
Marburg Virus- A Threat During SARS-CoV-2 Era: A Review
Authors: Ashique Sumel , Chaudhary Vatan , Pal Soumen , Panwar Jonee , Kumar Mukesh , Pramanik Soumi , Sinha Abhipsa , Mukherjee Anagh
Published: February 2023

In the German towns of Marburg, Frankfurt, and Belgrade in 1967, this single negativestranded
RNA virus was initially discovered. The importation of infected grivet monkeys from Uganda
is what caused this virus-related sickness. As a result of the early link between viruses and non-human
primates, this virus is frequently referred to as vervet monkey sickness. This virus causes Marburg
hemorrhagic fever in humans and non-human primates. Human endothelial cells serve as the primary
vehicle for replication. According to a 2009 report, the virus was being stored in Egyptian fruit bats
(Rousettus aegyptiacus). Body fluids, unprotected sex, broken or injured skin, and other bodily fluids
are the main routes of transmission. After the incubation period, symptoms like chills, headaches, myalgia,
and stomach pain start to show up. There is no specific medication for such an infection, only
hydration therapy and adequate oxygenation are followed. The following diagnostic techniques can be
used to confirm the diagnosis: (i) an antibody-capture enzyme linked immunosorbent assay (ELISA);
ii) an antigen capture ELISA test; iii) a serum neutralization test; iv) an RT PCR assay; v) electron
microscopy; or vi) virus isolation by cell culture. Because MARV is a risk group 4 infection, laboratory
staff must take strict precautions (RG-4).
Promising Radiopharmaceutical Tracers for Detection of Cardiotoxicity in
Cardio-oncology
Authors: Shaghaghi Zahra , Jalali Zefrei Fatemeh , Salari Arsalan , Hojjati Seyed Amineh , Fakhr Mousavi Seyed Aboozar , Farzipour Soghra
Published: February 2023

Cancer treatment has the potential to cause cardiovascular issues and can encourage the
appearance of all aspects of cardiac disease, including coronary heart disease, myocardial disease,
heart failure, structural heart disease, and rhythm problems. Imaging is required for both diagnostic
workup and therapy monitoring for all possible cardiovascular side effects of cancer therapy.
Echocardiography is the cardiac imaging gold standard in cardio-oncology. Despite advancements
in its use, this method is often not sensitive to early-stage or subclinical impairment. The use of
molecular imaging technologies for diagnosing, assessing, and tracking cardiovascular illness as
well as for treating, it is fast growing. Molecular imaging techniques using biologically targeted
markers are gradually replacing the traditional anatomical or physiological approaches. They offer
unique insight into patho-biological processes at the molecular and cellular levels and enable the
evaluation and treatment of cardiovascular disease. This review paper will describe molecularbased
single-photon emission computed tomography (SPECT) and positron emission tomography
(PET) imaging techniques that are now available and in development to assess post-infarction cardiac
remodeling. These methods could be used to evaluate important biological processes such as
inflammation, angiogenesis, and scar formation.
Multi-Factor Authentication Protocol Based on Electrocardiography Signals for a Mobile Cloud Computing Environment
Authors: Albuquerque Silas L. , Miosso Cristiano J. , da Rocha Adson F. , Gondim Paulo R. L.
Published: February 2023

Mobile Cloud Computing (MCC) is a highly complex topic that encompasses several information security issues. The authentication area of the various entities involved has been extensively discussed in recent years and shown a wide range of possibilities. The use of inadequate authentication processes leads to several problems, which range from financial damage to users or providers of Mobile Commerce (M-Commerce) services to the death of patients who depend on Mobile Healthcare (M-Health) services.

The design of reliable authentication processes that minimize such issues involves the use of non-intrusive authentication techniques and continuous authentication of users by MCC service providers. In this sense, biometrics may satisfy such needs in various scenarios.

This research has explored some conceptual bases and presents a continuous authentication protocol for MCC environments. Such a protocol is part of a cyberphysical system (CPS) and is based on the monitoring of physiological information interpreted from users’ electrocardiograms (ECG). Machine learning techniques based on the Adaptative Boost (Adaboost) and Random Undersampling Boost (RUSBoost) were used for the classification of the cardiac cycles recognized in such ECGs.

The two ML techniques applied to electrocardiography were compared by a random subsampling technique that considers four analysis metrics, namely accuracy, precision, sensitivity, and F1-score. The experimental results showed better performance of RUSBoost regarding accuracy (97.4%), precision (98.7%), sensitivity (96.1%), and F1- score (97.4%).
Implementation of leadership training policy in the local government of Gorontalo regency
Authors: Rachman Azis , Sudarsono Sudarsono , Darise Annisa Giana
Published: February 2023

The aims of this study were: (1) to find out the implementation of the Leadership Training Policy within the Local Government of Gorontalao Regency in terms of training planning, training implementation, and training evaluation. (2) to find out the factors that determine the implementation of the Leadership Training Policy within the Regional Government of Gorontalo Regency. This study used a qualitative approach and descriptive research using data collection techniques through observation, in-depth interviews, and documentation. Data analysis techniques were carried out through the stages of data reduction, data presentation, and conclusion. The results of the study show that (1) the Implementation of the Leadership Training Policy in the Regional Government of Gorontalo Regency seen from the training planning has been carried out maximally, while when viewed from the training implementation and training evaluation it has not been carried out optimally. (2) Communication, Resources, Executor's Attitude, and Bureaucratic Structure are the factors that determine the Implementation of Leadership Training Policy in the Gorontalo Regency Government, where Communication, Implementer's Attitude, and Bureaucratic Structure have been well implemented. Meanwhile, the main problem with the non-implementation of Leadership Training is the unavailability of a budget from the regional government.
Pengaruh Lama dan Intensitas Cahaya Terhadap Performa Produksi pada Ayam Arab (Gallus Turciccus)
Authors: Putra Aditya Wirawantoro , Trisunuwati Pratiwi , Muharlien Muharlien , Widyaputri Tiara
Published: February 2023

Cahaya dalam hal ini lampu adalah faktor penting dan merupakan terobosan sistem pencahayaan yang efisien untuk pengembangan peternakan ayam Arab. Penelitian ini bertujuan untuk mengetahui performa produksi (fase awal bertelur, hen day production, dan berat telur) pada ayam Arab dengan menggunakan perbedaan intensitas cahaya dan lama pencahayaan. Materi penelitian ini adalah 36 ekor ayam Arab fase layer dengan rataan bobot badan 924,28 Â± 90,45 g. Metode penelitian yang digunakan adalah percobaan, dengan Rancangan Acak Lengkap faktorial 2x2. Ternak dipelihara selama 9 minggu didalam kandang baterai. Data dianalisis menggunakan uji sidik ragam (ANOVA) dengan bantuan Program Microsoft Excel 2013. Apabila berbeda nyata (P<0,05) atau sangat nyata (P<0,01) dilanjutkan dengan uji Duncanâ€™s. Hasil penelitian menunjukkan bahwa perlakuan intensitas cahaya dan lama pencahayaan tidak memberikan pengaruh berbeda nyata (P<0,05) pada performa produksi ayam Arab. Secara umum, fase awal bertelur yang paling cepat adalah kelompok I1L1 yaitu bertelur pada rata-rata umur 145,11 hari. Berat telur paling tinggi pada fase puncak adalah kelompok I1L1 dengan rata-rata 36,03 gram/butir. Kesimpulan pada penelitian ini adalah intensitas cahaya dan lama pencahayaan yang berbeda memiliki dampak terhadap performa produksi ayam Arab.
Energy Spectrum and Optical Properties of Fullerene C-=SUB=-50-=/SUB=-(D-=SUB=-5h-=/SUB=-) within the Hubbard Model
Authors: Silant'ev A. V.
Published: February 2023

The energy spectra of C50 fullerene and molecule C50Cl10 of symmetry group D5h were obtained within the Hubbard model in the mean-field approximation. Using group theory methods, the classification of energy states was carried out, and the allowed transitions in the energy spectra of C50 and C50Cl10 molecules of symmetry group D5h were determined. On the basis of this spectrum, an interpretation of experimentally observed optical absorption bands of molecule C50Cl10 is proposed. Keywords: Hubbard model, Green's functions, energy spectrum, nanosystems, C50 fullerene.
On-chip ATR sensor (λ = 3.4 μm) based on InAsSbP/InAs double heterostructure for the determination of ethanol concentration in aqueous solutions
Authors: Karandashev S. A.  , Klimov A. A.  , Lukhmyrina T. S.  , Matveev B. A.  , Remennyi M. A.  , Usikova A. A.
Published: February 2023

We discuss photoelectrical properties of an on-chip attenuated total reflection (ATR) sensor for the ethanol concentration measurements in an aqueous solution. The on-chip sensor/microchip was made from a p-InAsSbP/n-InAs monolithic double heterostructure with three mesas/individual diodes grown on a single n+-InAs substrate/waveguide. Two heterostructure diodes were used as photodiodes, while the third one - as a LED. The ethanol concentration was measured via an algorithm based on analysis of the I-V characteristic parameters of a photodiode and the L-I characteristics of the LED. Keywords: photodiodes in the mid-IR range, LEDs in the mid-IR range, on-chip sensor, optical sensors, ATR sensor.
Studying the Optical Transitions of Carbon Dots from o-Phenylenediamine Depending on the Solvents and Additional Precursors
Authors: Arefina I.A.  , Vedernikova A.A.  , Fedorov A.V.  , Baranov A.V.  , Ushakova E. V.
Published: February 2023

In recent years, carbon dots have attracted much scientific attention due to their unique properties, which can find applications in many fields. We have developed synthesis protocols of carbon dots with different structure and optical properties using o-phenylenediamine. The change in absorption and luminescence spectra of carbon dots were studied in detail. The obtained samples show intensive luminescence at 350 nm and 450 or 550 nm dependent on synthesis parameters. Keywords: Carbon dots, photoluminescence, spectroscopy.
Empirical quality criteria for the approximation of the electronic term of a diatomic molecule by the Morse formula
Authors: Denisov G. S.
Published: February 2023

A brief review of the latest results of the application of the approximation of the potential of a diatomic molecule by the Morse model function in applied spectroscopy is presented. The functions of the electronic terms of the diatomic molecules BeH, F2, H2, HCl, and Be2 are compared with their two alternative approximations by the Morse function. As a criterion, we used the differences between the original (approximated) term and its Morse models, which, combined with the dependence of the anharmonicity of the original terms on the vibrational quantum number ωexe(v), allowed to formulate some generalizations about the deformation of the form the original term in the approximations. Simulation always leads to an increase in the bond energy in the range of 7-50% and to an increase in the number of vibrational levels. In favorable cases, the contour shape is reproduced with a deviation of no more than 100-200 cm-1 in the lower part of the potential well. Key words: Morse formula, diatomic molecule, anharmonicity, electronic terms, vibrational structure.
Ab Initio Study of the Interaction Potentials of CF-=SUB=-4-=/SUB=-, CH-=SUB=-4-=/SUB=-, SiF-=SUB=-4-=/SUB=- and SiH-=SUB=-4-=/SUB=- Molecules with the Rb Atom in the Ground and Electronically Excited States
Authors: Alekseev V. A.
Published: February 2023

The potentials of the electronic states of RbXY4 molecules, XY4 = CF4, CH4, SiF4 and SiH4, correlating with the ground 5s 2S1/2 and excited 5p ^2P1/2,3/2 states of the Rb atom are studied using the methods of ab initio quantum chemistry. The calculations are performed by the SCF method of the full active space of orbitals, taking into account dynamic electronic correlations and spin-orbital interaction. It is established that the character of the interaction in the A and A' states, correlating respectively with the lower and upper states of the Rb (5p ^2P1/2,3/2) doublet and corresponding to the perpendicular orientation of the Rb p-orbital relative to the Rb-X axis, differ significantly (attraction or repulsion) for different XY4 molecules, which is explained by the difference in the charge distribution in the XY4 molecules. In order to evaluate the accuracy of the calculation results for RbXY4 molecules, similar calculations are performed for the diatomic RbAr molecule using different basis sets. It is found that, as compared with the A and A' states, the potential of the repulsive B state, which correlates with the upper state of the doublet and corresponds to the orientation of the Rb p-orbital along the Rb-X axis, is significantly more sensitive to the size of the basis set which is due to the accuracy of accounting for the configuration interaction with states that correlate with the Rb (6s ^2S1/2) and Rb (4d ^2D3/2,5/2) states and other states of the Rb atom lying above Rb (5p ^2P1/2,3/2). Keywords: alkali metals, excited states, carbon tetrafluoride, quantum chemistry, ab initio calculations.
Features of absorption of thin films La-=SUB=-0.69-=/SUB=-Ba-=SUB=-0.31-=/SUB=-MnO-=SUB=-3-delta-=/SUB=- obtained using the method of pulsed laser deposition
Authors: Bessonova V. A.  , Telegin A. V.  , Nosov A. P.  , Sukhorukov Yu. P.
Published: February 2023

The electrical, optical, and magneto-optical properties of La0.69Ba0.31MnO3-delta thin films with a Curie temperature near room temperature are studied. It is shown that in the region of the phase transition there is a sharp change in the behavior of the temperature dependences of the electrical resistance and optical transparency of the films, which is associated with the insulator-metal transition. In a narrow temperature region near the transition, a change in the external magnetic field leads to the appearance of negative magnetoresistance and magnetotransmission of unpolarized light in the spectral range from 1 to 12 μm. It is shown that the effect of magnetic transmission (magnetoabsorption) in films is mainly due to the contribution of free charge carriers. The magnetic transmission spectra are sensitive to the magnetic and electronic inhomogeneities of the films. Keywords: Thin films, manganites, magnetoabsorption, colossal magnetoresistance, IR spectroscopy, metal-insulator transition, magnetic inhomogeneities.
Amplification of the electric area of a pulse during reflections from a moving mirror
Authors: Rosanov N. N.
Published: February 2023

An analysis was made of the transformation of the electric area of an electromagnetic pulse upon reflection from a moving mirror. Conditions are found under which reflection leads to an increase (in absolute value) of the electric area. For a dynamic resonator, one of the mirrors of which periodically oscillates, an expression is obtained for the threshold for generating pulses with an ever-increasing area. Nonlinear factors that limit the exponential growth of the pulse electric area are discussed. Keyword: pulse electric area, unipolar pulse, dynamic resonator.
Laser processing of fused silica for fabricating microfluidic elements
Authors: Bondarenko A. G.  , Zakoldaev R. A.  , Ramos-Velazque A.
Published: February 2023

The paper discusses the action of the power and the scanning speed of CO2-laser radiation on the surface of fused silica for the manufacture of microchannels and microreservoirs for microfluidics tasks is investigated. The dependences of the size and the roughness of microstructures on of laser radiation parameters is established. The depth of microfluidic elements reaches 45 μm with a roughness of < 40 nm. The velocity of liquid propagation (up to 15 mm/s) is estimated for the microchannels fabricated. The wettability of microreservoirs is evaluated, with the wetting angle reaching 64± 7o. The fabricated elements have a high transmission (T≥ 0.8) in the visible spectral range. Keywords: CO2-laser, microchannel fused silica, microfluidics.
Temperature sensor on base of pne-dimensional photonic crystal with defect
Authors: Sidorov A. I.  , Vidimina Yu. O.
Published: February 2023

The results of computer simulation of optical properties of one-dimensional (1D) photonic crystal with defect, based on semiconductor-dielectric layers are presented. As semiconductor silicon and germanium were used. The influence of temperature on spectral position of defect transmission band was studied. It was shown that for photonic crystal based on silicon temperature sensitivity is 0.07 nm/K and 2.6 dB/K. For photonic crystal based on germanium --- 0.37 nm/K and 7.8 dB/K. This makes such photonic crystals promising for use in temperature sensors as sensitive element. Keywords: temperature sensor, photonic crystal, photonic bandgap, transfer matrix.
An Interview with Assoc. Prof. Carlo Santulli
Authors: Editorial Office Recent Progress in Materials
Published: February 2023

InterviewAn Interview with Assoc. Prof. Carlo SantulliRecent Progress in Materials Editorial OfficeLIDSEN Publishing Inc., 2000 Auburn Drive, One Chagrin Highlands, Suite 200, Beachwood, OH, USA; E-Mail: rpm@lidsen.com Recent Progress in Materials2023, volume 5, issue 1doi:10.21926/rpm.2301010Received: February 26, 2023Accepted: February 26, 2023Published: February 27, 2023
Marchitez en el cultivo de aguacate
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

En este clip se da la recomendación tecnológica para controlar y prevenir la marchitez en el cultivo de aguacate en el departamento de Antioquia.
Siembra de cacao: tres bolillos
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

En este clip se enseña a realizar el paso a paso del sistema de siembra tres bolillos en cultivos de cacao.
Siembra de yuca forrajera
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

En este clip tecnológico se presenta el paso a paso de cómo sembrar la yuca forrajera en el Caribe seco colombiano.
Planeación en cultivos de cítricos
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

En este clip se muestra cual debe ser la correcta planeación, para establecer un cultivo de cítricos.
Poda de aguacate
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

En este clip se presenta el paso a paso cómo se desarrolla la poda en el cultivo de aguacate.
Cardiff Online Cognitive Assessment in a National Sample: Cross-Sectional Web-Based Study (Preprint)
Authors: Lynham Amy Joanne , Jones Ian R , Walters James T R
Published: February 2023

BACKGROUND

Psychiatric disorders are associated with cognitive impairment. We have developed a web-based, 9-task cognitive battery to measure the core domains affected in people with psychiatric disorders. To date, this assessment has been used to collect data on a clinical sample of participants with psychiatric disorders.

OBJECTIVE

The aims of this study were (1) to establish a briefer version of the battery (called the Cardiff Online Cognitive Assessment [CONCA]) that can give a valid measure of cognitive ability (“g”) and (2) to collect normative data and demonstrate CONCA’s application in a health population sample.

METHODS

Based on 6 criteria and data from our previous study, we selected 5 out of the original 9 tasks to include in CONCA. These included 3 core tasks that were sufficient to derive a measure of “g” and 2 optional tasks. Participants from a web-based national cohort study (HealthWise Wales) were invited to complete CONCA. Completion rates, sample characteristics, performance distributions, and associations between cognitive performance and demographic characteristics and mental health measures were examined.

RESULTS

A total of 3679 participants completed at least one CONCA task, of which 3135 completed all 3 core CONCA tasks. Performance on CONCA was associated with age (B=–0.05, SE 0.002; P<.001), device (tablet computer: B=–0.26, SE 0.05; P<.001; smartphone: B=–0.46, SE 0.05; P<.001), education (degree: B=1.68, SE 0.14; P<.001), depression symptoms (B=–0.04, SE 0.01; P<.001), and anxiety symptoms (B=–0.04, SE 0.01; P<.001).

CONCLUSIONS

CONCA provides a valid measure of “g,” which can be derived using as few as 3 tasks that take no more than 15 minutes. Performance on CONCA showed associations with demographic characteristics in the expected direction and was associated with current depression and anxiety symptoms. The effect of device on cognitive performance is an important consideration for research using web-based assessments.

CLINICALTRIAL
Training Physicians in the Digital Health Era: How to Leverage the Residency Elective (Preprint)
Authors: Hsiang Esther Y , Ganeshan Smitha , Patel Saharsh , Yurkovic Alexandra , Parekh Ami
Published: February 2023

UNSTRUCTURED

Digital health is an expanding field and is fundamentally changing the ways health care can be delivered to patients. Despite the changing landscape of health care delivery, medical trainees are not routinely exposed to digital health during training. In this viewpoint, we argue that thoughtfully implemented immersive elective internships with digital health organizations, including start-ups, during residency are valuable for residents, residency programs, and digital health companies. This viewpoint represents the opinions of the authors based on their experience as resident physicians working as interns within a start-up health navigation and telehealth company. First, residents were able to apply their expertise beyond the traditional clinical environment, use creativity to solve health care problems, and learn from different disciplines not typically encountered by most physicians in traditional clinical practice. Second, residency programs were able to strengthen their program’s educational offerings and better meet the needs of a heterogenous group of residents who are increasingly seeking nontraditional ways to learn more about care delivery transformation. Third, digital health companies were able to expand their clinical team and receive new insights from physicians in training. We believe that immersive elective internships for physicians in training provide opportunities for experiential learning in a fast-paced environment within a field that is rapidly evolving. By creating similar experiences for other resident physicians, residency programs and digital health companies have a key opportunity to influence future physician-leaders and health care innovators.
The use of AI-technology to determine the carbon footprint of spinal surgery: experiences of a tertiary centre (Preprint)
Authors: Shah Savan , Barnard Heidi , Joshi George Kuriakose
Published: February 2023

BACKGROUND

The healthcare industry is a significant contributor to global emissions, with the operating theatre representing a key contributor. Inquiry into the ecological impact of surgery is a novel and important field of research.

OBJECTIVE

Here, we outline the carbon footprint of a lumbar microdiscectomy at our regional unit in Greater Manchester with the use of AI technology. In doing so, we aim to define the extent of the environmental impact and identify targets for sustainable change.

METHODS

Our functional unit of analysis was defined as the start of the patient journey into hospital through to the final outpatient appointment. We used a combination of publicly available and locally sourced data. A detailed inventory analysis of two lumbar microdiscectomies were conducted. Each item was categorised reconciled against our AI-powered ‘CO2 analysis’ database. Kilograms of carbon dioxide equivalent (kg CO2e) was chosen as the primary measure of impact.

RESULTS

An average lumbar microdiscectomy at our trust, as per our defined functional unit of analysis generates 477.73kg CO2e, equivalent to a return flight from Manchester to Berlin. The operation (173.89kg CO2e, 36.40%) and the inpatient stay (144.67kg CO2e, 30.28%) constituted the biggest contributors. Single-use intraoperative equipment contributed to over three-quarters of the total emissions from the operation.

CONCLUSIONS

By defining the environmental burden of elective spinal surgery, we have identified carbon hotspots that can be targeted for sustainable change. By substituting polluting elements for carbon-friendly alternatives and challenging the single-use culture, we can all play our part in paving the way to a ‘net zero’ healthcare system.
Digital Phenotyping for Monitoring Mental Disorders: Systematic Review (Preprint)
Authors: Bufano Pasquale , Laurino Marco , Said Sara , Tognetti Alessandro , Menicucci Danilo
Published: February 2023

BACKGROUND

The COVID-19 pandemic has increased the impact and spread of mental illness and made health services difficult to access; therefore, there is a need for remote, pervasive forms of mental health monitoring. Digital phenotyping is a new approach that uses measures extracted from spontaneous interactions with smartphones (eg, screen touches or movements) or other digital devices as markers of mental status.

OBJECTIVE

This review aimed to evaluate the feasibility of using digital phenotyping for predicting relapse or exacerbation of symptoms in patients with mental disorders through a systematic review of the scientific literature.

METHODS

Our research was carried out using 2 bibliographic databases (PubMed and Scopus) by searching articles published up to January 2023. By following the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines, we started from an initial pool of 1150 scientific papers and screened and extracted a final sample of 29 papers, including studies concerning clinical populations in the field of mental health, which were aimed at predicting relapse or exacerbation of symptoms. The systematic review has been registered on the web registry Open Science Framework.

RESULTS

We divided the results into 4 groups according to mental disorder: schizophrenia (9/29, 31%), mood disorders (15/29, 52%), anxiety disorders (4/29, 14%), and substance use disorder (1/29, 3%). The results for the first 3 groups showed that several features (ie, mobility, location, phone use, call log, heart rate, sleep, head movements, facial and vocal characteristics, sociability, social rhythms, conversations, number of steps, screen on or screen off status, SMS text message logs, peripheral skin temperature, electrodermal activity, light exposure, and physical activity), extracted from data collected via the smartphone and wearable wristbands, can be used to create digital phenotypes that could support gold-standard assessment and could be used to predict relapse or symptom exacerbations.

CONCLUSIONS

Thus, as the data were consistent for almost all the mental disorders considered (mood disorders, anxiety disorders, and schizophrenia), the feasibility of this approach was confirmed. In the future, a new model of health care management using digital devices should be integrated with the digital phenotyping approach and tailored mobile interventions (managing crises during relapse or exacerbation).
Resiliensi Bisnis Pada Usaha Mikro Kecil dan Menengah dalam Masa Pandemi COVID-19 (Studi Kasus pada Pengusaha Batik di Daerah Istimewa Yogyakarta)
Authors: Akmal Nazufa Hunain , Arifa Choirunnisa
Published: February 2023

Pada awal tahun 2020 World Health Organization (WHO) telah menetapkan coronavirus (COVID-19) sebagai sebuah pandemi. Situasi krisis akibat pandemi memberikan efek buruk dan ketidakpastian dalam jangka panjang terhadap kondisi sosial dan ekonomi di suatu negara. Dampak pandemi ini tidak hanya dirasakan oleh perusahaan besar namun juga UMKM, yang merupakan salah satu tulang punggung perekonomian di Indonesia. Salah satu UMKM yang terdampak adalah UMKM Batik, setidaknya terdapat 50% pengusaha batik yang gulung tikar akibat pendemi COVID-19. Penelitian ini bertujuan mengidentifikasi strategi bertahan UMKM Batik di DIY dalam menghadapi pandemi COVID-19 serta mengeksplorasi karakteristik resiliensi kewirausahaan yang mereka miliki. Dalam penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Proses pengumpulan data dilakukan melalui wawancara, observasi dan dokumentasi. Hasil penelitian ini menunujukkan strategi bertahan yang dilakukan UMKM dalam menghadapi pandemi COVID-19 yaitu; adaptasi penyesuaian harga jual, adaptasi penggunaan digital marketing, antisipasi dengan dana tabungan, efisiensi melalui cost reduction, fleksibilitas UMKM, inovasi produk dan proses, relasi dengan customer, serta relasi dengan pemerintah dan universitas. Selanjutnya, karakteristik resiliensi kewirausahaan yang dimiliki pelaku usaha batik di DIY menunjukkan bahwa: (1) perilaku orang tua yang memberikan kebabasan dan tanggung jawab berdampak terhadap mental, sikap, kemandirian dan kepercayaan diri yang dimiliki setiap individu serta kondisi krisis sudah biasa dihadapi oleh para subjek dalam penelitian ini bahkan sejak mereka masih kecil, (2) pengalaman orang tua dalam berbisnis menginspirasi serta mengajarkan mereka untuk menjadikan kewirausahaan sebagai way of life, (3) seorang wirausahawan yang sukses tidak datang secara instan melainkan harus melalui proses belajar yang panjang melalui berbagai pengalaman bisnis sebelumnya, (4) sikap dan perilaku positif membantu seorang wirausahawan untuk menghadapi segala tantangan dan permasalahan yang ada seperti menganggap segala rangkaian pekerjaan sebagai suatu hal yang menyenangkan bagi mereka. Disamping itu, temuan tambahan dalam penelitian adalah adanya strategi bertahan melalui relasi dengan komunitas dan masyarakat serta terdapat aspek religiusitas yang meningkatkan resiliensi UMKM Batik di DIY selama pandemi COVID-19.
Telaah Pengukuran Kinerja Pada Dinas Kelautan Dan Perikanan Provinsi Jawa Tengah: Kasus Pada Loka Perbenihan Ikan Air Payau Sluke Tahun 2022
Authors: Faisal Muhammad Ali , Nurhatyo Ertambang
Published: February 2023

Penelitian ini bertujuan untuk menganalisis pengukuran kinerja dan memberikan rekomendasi yang dapat mendorong upaya peningkatan kinerja organisasi pemerintah di bidang produksi dan pelayanan publik sektor perikanan dengan model balanced scorecard.Penelitian ini merupakan penelitian deskriptif kualitatif dengan pendekatan studi kasus. Sumber data dalam penelitian ini, yaitu data primer berupa hasil wawancara mendalam dengan koordinator, karyawan, dan pelanggan di LPIAP Sluke dan data sekunder berupa analisis data karyawan, laporan keuangan, produksi, dan penjualan tahun 2021-2022.Hasil penelitian menunjukkan bahwa dari total 23 indikator kinerja utama (IKU) terdapat 2 IKU tidak mencapai target dan 2 IKU yang belum mencapai target, tetapi diperkirakan akan mencapai target pada akhir tahun 2022. Hasil analisis juga menunjukkan bahwa LPIAP Sluke sebenarnya kekurangan tenaga kerja kompeten dan terlatih di bidang perikanan, hal ini tidak dapat diidentifikasi melalui pengukuran kinerja secara tradisional yang selama ini diterapkan di LPIAP Sluke. Selain itu, penuangan hasil pengukuran kinerja ke dalam matriks maturity grid memberikan beberapa rekomendasi yang dapat digunakan untuk mendorong peningkatan kinerja organisasi.
Local Grid Planning and Design
Authors: Yang Lifan
Published: February 2023

This design is based on Etap simulation software to complete the following steps: analysis of original data, determination of power grid voltage level and preliminary selection of power grid connection scheme, technical and economic operation of optimal scheme, operation characteristics and material statistical calculation. Through this design, I have mastered the general principles and common methods of power network planning and design. I am skilled in using Etap simulation software to cultivate my analytical ability in various aspects of technology and economy, improve my ability of calculation, data analysis and arrangement, and design specification compilation.
3.6kV Vacuum Interrupter Design
Authors: Yang Lifan
Published: February 2023

This paper analyzes and compares the principle and structure of the vacuum interrupter, so as to determine the selection of materials for the vacuum interrupter, and further compares the structural materials of the interrupter, and compares them from three angles: the shell, the contact, and the shield.
Formulación de una propuesta de Ley para desarrollar la transformación digital del Ecuador.
Authors: Barragán Martínez Xavier
Published: February 2023

La presente investigación tiene como objetivo el formular una propuesta de ley para la transformación digital del Ecuador; basado en una metodología descriptiva cualitativa, a través de talleres de expertos llevados a cabo por el MINTEL, y un  análisis documental bibliográfico de fuentes primarias y fuentes secundarias de organismos internacionales y nacionales, se obtuvieron resultados que muestran la imperante necesidad de adecuar el marco legislativo vigente para obligar a las instituciones públicas a establecer comunicación por medios electrónicos; desarrollar y/o usar plataformas digitales sostenibles y reutilizables para la presentación de documentos de manera ininterrumpida; mantener expedientes electrónicos; cooperar e interoperar en todo procedimiento administrativo con las entidades de la Administración Pública, y garantizar la gobernanza pública conformando un comité estratégico con atribuciones para promover el uso y la apropiación de las TIC; así como asesorar, acompañar, coordinar y dar seguimiento al cumplimiento de las políticas en materia de transformación digital.
Responsabilidad penal de las personas jurídicas en el Ecuador:
Authors: Vanegas Fernández Héctor Gabriel
Published: February 2023

El objeto de estudio de este trabajo académico será repasar los componentes legales y dogmáticos que han dado sentido a este sistema sobre la responsabilidad penal de las personas jurídicas en el Ecuador. Se busca de manera crítica repasar todas las reformas que ha tenido que pasar el modelo en nuestro país, además, delimitar de manera clara las carácteristicas fundamentales que comprenden nuestro sistema de RPPJ, de conformidad a las acepciones establecidas en nuestro Código Orgánico Integral Penal; todo para abordar la perspectiva a futuro, que tiene como objetivo lograr la aplicabilidad práctica del sistema, mediante la aceptación de los programas de cumplimiento normativo o compliance, como mecanismos de eximente de responsabilidad, que generen incentivo suficiente a las corporaciones para que operen como aliados estratégicos en la detección y denuncia del fenómeno criminal en el seno empresarial.
diferenciación vs. discriminación como línea de tendencia en los regímenes de inmigración y asilo:
Authors: La Spina Encarnación
Published: February 2023

Si bien, las personas migrantes son uno de los colectivos mayormente excluidos y reciben un trato diferenciado en el acceso y la garantía de los derechos humanos. No por ello, el marco conceptual y jurídico tendente a promover su protección ha reforzado la aplicación del principio de igualdad y no discriminación en contextos migratorios. La configuración jurídica de los derechos de las personas migrantes en las Naciones Unidas y actualmente en la Unión Europea requiere una crítica y debate más reflexivo sobre el alcance de la diferenciación y sus límites conforme al principio de no discriminación. Por consiguiente, este artículo plantea una revisión de las limitaciones existentes en la categorización convencional de los derechos de las personas migrantes que contravienen el principio de no discriminación y, trata de cuestionar la legitimidad de la diferenciación de categorías jurídicas cuando la apelada diferencia no tiene una justificación objetiva y razonable.
Effect of pregnancy on some haematological and biochemical parameters in pregnant Chinese water deer (Hydropotes inermis)
Authors: Nie Dayi , Tang Haiming , Lin Yi , Liu Jiazhong , Gui Jianfeng , Zhao Na , Zhang Endi , Chen Min
Published: February 2023

The haematological and biochemical parameters of endangered wild animals in gestation can provide the knowledge of normal physical conditions and recognition of every abnormality, then contribute to conservation and management. For better breeding management of Chinese water deer (Hydropotes inermis) reintroduced population, a series of haematological and biochemical parameters were tested and analyzed, viz. white blood cells (WBC), red blood cells (RBC), haemoglobin (HGB), packed-cell volume (PCV), platelet count (PLT), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), mean corpuscular volume (MCV), mean red blood cells distribution width coefficient of variation (RDW) and different hematological parameters viz. total protein (TP), albumin (ALB), globulin (GLB), albumin to globulin ratio (A/G), total bilirubin (TBIL), alkaline phosphatase (ALP), γ-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT, creatinine, urea (BUN), uric acid, total cholesterol (TC), triglyceride, creatine kinase (CK), lactate dehydrogenase (LDH) and cortisol. The WBC value of non-pregnants was significantly higher than that of pregnants; the total cholesterol and total bilirubin concentration was significantly lower in pregnants. The hematological and serum biochemical parameters to change when the pregnant Chinese water deer pregnancy, which could be used in health monitoring and disease diagnosis of the Chinese water deer and reference for other cervids.
La influencia de la jurisprudencia de la Corte Interamericana de Derechos Humanos en el derecho interno de los Estados latinoamericanos
Authors: Ovalle Favela José
Published: February 2023

En este trabajo el autor analiza la influencia de la jurisprudencia de la Corte Interamericana de Derechos Humanos en la evolución reciente del derecho interno de los Estados latinoamericanos. Para este fin se ocupa de la creación y funciones de la Comisión Interamericana y la Corte Interamericana de Derechos Humanos. De esta última, estudia su integración y su competencia, tanto consultiva como contenciosa, así como las características de su jurisprudencia. También aborda el tema del control de la convencionalidad tanto en sede internacional, que ejerce la Corte Interamericana, cuanto a la que en sede nacional o interna compete a los poderes internos de cada Estado, particularmente a los jueces. Por último, el autor analiza cinco casos específicos.
Sistema jurídico, represión y derechos humanos en la España contemporánea
Authors: Vergara Óscar
Published: February 2023

Según la teoría contemporánea, un sistema jurídico existe cuando es eficaz en general. Así, identificar las normas jurídicas válidas en tal sistema sólo requiere cumplir con los requisitos establecidos en su correspondiente regla de reconocimiento. De modo que ni en la cuestión de la existencia del sistema ni en la de la identificación de sus normas tiene que ver la de la moralidad del derecho. Esto se pone en cuestión en este trabajo a través del análisis del derecho de la represión durante la dictadura franquista y las medidas reparadoras adoptadas a partir de la transición a la democracia hasta nuestros días.
Análisis desde la perspectiva del derecho internacional de los derechos humanos del juicio de inconformidad para la invalidez de elecciones presidenciales de 2012 en México
Authors: Rodríguez Santibáñez Iliana
Published: February 2023

La coalición Movimiento Progresista (cuyo candidato a la presidencia de México fue Andrés Manuel López Obrador) presentó el 12 de julio de 2012 un juicio de inconformidad que argumentaba la violación del artículo 41 constitucional, por lo cual se solicitaba al Tribunal Electoral del Poder Judicial de la Federación que declarara la elección presidencial inválida y por consiguiente se anulara. En el juicio de inconformidad se solicitó literalmente: “la nulidad de la elección […], solicitando la declaración de no validez […] por violación a los principios constitucionales de elecciones auténticas y sufragio libre y por la cancelación del registro de candidato al c. Enrique Peña Nieto por rebase de topes de campaña”. En esta sentencia se encuentran temas relevantes que son analizados desde la óptica del derecho internacional de los derechos humanos.
La Carta Democrática Interamericana y la Corte Interamericana de Derechos Humanos
Authors: Salas Cruz Armando
Published: February 2023

El presente trabajo, después de analizar los orígenes y características esenciales de la Carta Democrática Interamericana, indaga su uso en las sentencias (casos contenciosos) de la Corte Interamericana de Derechos Humanos. Se concluye que a pesar del origen político de este instrumento regional y teniendo como fin primario la defensa colectiva de la democracia, este tribunal la ha posicionado como un documento relevante en la interpretación de los derechos políticos reconocidos en la Convención Americana sobre Derechos Humanos. En este sentido, existe una relación benéfica entre la CDI y la CADH que ha contribuido a un entendimiento más amplio de estos derechos, favoreciendo nuevos desarrollos.
Seismic Analysis of a Floating Column with Two Different Position of Building Using Software’s
Authors: Patange Ms. Shivani , Jain Dr. R. K. , Deshpande Mrs. Girija
Published: February 2023

Abstract: In present scenario buildings with floating columns is typical features in the modern multi-storey construction in urban India. Such features are highly undesirable in building built in seismically active areas. This study highlights the importance of explicitly recognising the presence of the first storey and the storey above, are proposed to reduce the irregularity introduced by the floating column. The behaviour of concrete structures is more vulnerable with the effect of floating columns resulted in failure of structures and severe damaged. The present project work is to the find the severity and effect of floating columns on the parameters of support reactions, axial forces, displacements, shear forces and twisting moments. In this paper using 3D finite element method & Matrix Displacement method seismic analysis of floating column With two different position is done for a multi-storey building. The structural response of the building models with respect to, base shear and storey displacements is investigated. The analysis is carried out using software ETABS & STAAD-PRO
Combining Blockchain and Image Processing to Counterfeit Goods Detection
Authors: Devi G. Kalpana , Bayaknol Prakash , Valandas Sai Vishruth , Sangeetham Sreekaran
Published: February 2023

stract: Fake products are a big problem since it's difficult to tell the difference between real and fake goods in today's environment. However, some people create these false goods for financial gain alone, without considering how they will affect customers or how they will influence a company's reputation, earnings, or sales. With blockchain technology, it is possible to verify the validity of a product and determine if it is real or false. Blockchain is a popular technology that is used in many applications. Information is maintained in the form of blocks in numerous databases that are connected by chains using blockchain technology, and no permission from outside users is needed. The immutability and security of blockchain technology are advantages.
Audio Visual Snakes and Ladders Game Development for SPLDV
Authors: Sholikah Rifatus , Taufik Marhan , Kusumawardana Adi Slamet
Published: February 2023

Many students still need help understanding SPLDV material. This research aims to develop learning media for snakes and ladders assisted by audio-visual aids using valid and effective PPT to improve learning outcomes and student learning enthusiasm in learning the Two-Variable Linear Equation System. The study subjects were 18 grade VIII students at SMP Muhammadiyah 2 Malang. The research method used is development or Research and Development (R&D). Data collection techniques used are test questions and questionnaires. Data analysis techniques using data analysis, namely quantitative descriptive with and calculating the average value of the pretest and posttest and the average percentage of the questionnaire value and the categorization of the percentage results. The results of this study indicate that the average effect of media validation is 94% in the very good category. Student learning outcomes are seen from the average student scores before and after using the media, namely, 32.5 and 83.89, which states that there are differences in learning outcomes students before and after using the media, as well as from the response questionnaire data students' enthusiasm for learning obtained an average of 83.74% which means very good. This states that audio-visual assisted snake and ladder learning media using PPT in learning the Linear Equation System of Two Variables is valid and effective in improving learning outcomes and student learning enthusiasm in the learning process.