bluuebunny/crossref_metadata_2025 huggingface dataset:
EXPRESS: The Sound of Status: Product Volume as a Status Signal of Dominance or Prestige
Authors: Lowe Michael , Jo Wooyong , Ward Morgan K. , Vohs Kathleen D.
Published: January 2025

Prior research on status signaling reveals that consumers may select subtle or overt signals to convey their social status. In this research, the authors build on this insight in the context of auditory signaling and show that consumers use product volume as a status signal. Using the Dominance-Prestige Account of Rank Allocation framework, the authors propose that the path consumers take to achieve status will influence their choice of loud or quiet products. A combination of quantitative models, a lab experiment and a conjoint study demonstrates that consumers pursuing status via dominance are more likely to choose relatively louder products, while those who use a prestige path are more likely to choose relatively quieter products. The authors further demonstrated a boundary condition for prestige-driven consumers, the presence of other signals of social rank, such as education or profession. When no other markers of their social rank are present prestige-driven people reduce their preference for quiet signals (Study 4).
Comparative analysis of new-generation thermoplastic polymers: Cyclic olefin copolymer and polycarbonate urethane elastomers
Authors: YURTBASI Zuhal , KASGOZ Alper
Published: January 2025

In this study, the thermal, rheological, mechanical, and viscoelastic properties of two new-generation thermoplastic polymers, namely cyclic olefin copolymer (COC) and polycarbonate urethane (PCU) elastomers, were compared to those of a conventional thermoplastic elastomer, thermoplastic polyurethane (TPU). Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) were used for thermal examinations, while rheological, tensile, and solid-state creep tests were used for viscoelastic and mechanical analyses. The DSC results revealed that all elastomers had two different T g values, which were −23 and 7.5°C for PCU, −40 and 95°C for TPU, and 4 and 55°C for COC. Moreover, PCU had an amorphous and more compatible structure than PCU and TPU. In the DMA, it was also observed that COC melted at approximately 90°C, while PCU and TPU melted at about 155°C. In the tensile tests, it was observed that COC showed higher strength at 30°C, but it lost its strength more effectively than the other polymers with increasing temperature and exhibited similar performance to all specimens at 50°C. Finally, in the solid-state creep tests, COC exhibited the highest creep resistance at 30°C, while its creep strain increased with temperature more effectively than those of the other elastomers.
Dyadic mechanisms of effect in home–school consultation: Evidence from two school-based consultation models
Authors: Dale Brittany A. , Ogle Lindsey N. , Ruble Lisa A. , Azad Gazi F.
Published: January 2025

The United States educational system struggles to provide supportive services as rates of autism spectrum disorder rise. Teachers face challenges in shared decision-making with caregivers for developing high-quality intervention plans tailored to the strengths, challenges, and needs of students with autism and their learning environments. We describe two school-based consultation approaches for supporting shared decision-making between parents/caregivers and teachers of students with autism – Partners in School and COMPASS. Both approaches bring parents/caregivers and teachers together for collaborative goal setting facilitated by a consultant through shared dyadic mechanisms of effect, which include shared decision-making, caregiver-teacher alliance, and agreement on educational goals. These innovative consultation models incorporate both the teacher and parent/caregiver perspectives early on when deciding on specific goals and strategies.
The 2016 United States Election and Financial Support to Migrant-Serving Legal-Aid Organizations
Authors: Pedroza Juan , Potochnick Stephanie , Santillano Robert
Published: January 2025

The 2016 US election of Donald Trump ushered in a wave of anti-immigrant rhetoric and federal policies that have been shown to harm immigrant families. This study examines how the election affected immigrant-serving community-based organizations (CBOs), which provide vital support to these communities and may mitigate harm. Focusing on migrant-legal CBOs — a key subset that offers pro-bono or low-cost legal services — and incorporating theories from organizations, social movements, and political opportunity, we assess whether these organizations were able to leverage the election as a focusing event to attract funding and whether they sustained this support over time. Using Internal Revenue Service records, we identify migrant-legal aid CBOs with a track record of delivering legal services to immigrant communities. Using synthetic control methods, we find that financial resources to migrant-legal CBOs increased from 4 to 11 percentage points during the 2016 election, and were 8 to 17 percentage points higher through 2019, the last year of available data. Our study shows that amid the shifting anti-immigrant policy climate of the Trump election, migrant-legal CBOs mobilized as a counterforce, using the socio-political landscape and public response as an opportunity to secure and sustain financial support, potentially acting as a safeguard against the escalating anti-immigrant climate.
“Together is no longer completely together”: Exploring the influence of social cognition problems on partner relationships following acquired brain injury
Authors: van den Broek Brenda , Muskens Jorn , van Heugten Caroline , Bus Boudewijn , Rijnen Sophie
Published: January 2025

Objective

To examine the experiences of individuals with acquired brain injury and their partners regarding the effects of social cognition problems on their relationships.

Design

Qualitative interview study.

Setting

Interviews were conducted 1 to 5 years post-injury, either in the participants’ home or at a care facility in the Netherlands.

Participants

Nine couples consisting of an individual with acquired brain injury and a partner without acquired brain injury. Scores on neuropsychological tests indicated social cognition difficulties in individuals with acquired brain injury.

Methods

Individual semi-structured interviews were conducted, audio recorded, and transcribed verbatim. Two independent analysts analyzed the data using thematic analysis aimed at finding common themes across the data set. Data analysis was carried out recursively and parallel to data collection to help determine when saturation was reached.

Results

Six themes were generated from the interview data: (1) partners feeling disappointed, lonely, and despondent, (2) individuals with acquired brain injury feeling insecure and ashamed of falling short, (3) relationship roles changing, (4) the aggravating role of fatigue and sensory hypersensitivity, (5) the importance of professional help, and (6) silver linings: increased awareness creating closeness.

Conclusion

Social cognition problems have the potential to strongly affect relationships between those with acquired brain injury and their partners in many ways. Addressing social cognition problems is recommended as it is greatly appreciated by individuals with acquired brain injury and their partners and holds promise for improving their relationship.
Barriers to Evacuating: A Study on Administrative Burdens to Special Needs Shelters
Authors: Entress Rebecca , Dougherty Ratna B. , Knox Claire Connolly
Published: January 2025

Emergencies, such as extreme weather events, require residents to evacuate for their safety. Past research suggests that administrative burdens—compliance, learning, and psychological costs—can impact the likelihood of evacuations to shelters. These burdens disproportionately impact socially vulnerable populations and create social equity issues. Florida operates special needs shelters to provide safe environments and basic assistance to individuals needing higher levels of care and supervision and ensure that special medical needs are met during an evacuation. Using data from 23 county after-action reports from Hurricane Irma, this article examines administrative burdens faced by individuals evacuating to special needs shelters. Although residents faced all three types of administrative burdens, psychological costs were most common, especially among counties with high social vulnerability. Based on the results, recommendations are provided for public administrators and emergency managers to reduce these administrative burdens when evacuating to special needs shelters during future emergencies.
Holixec Education: The Right Direction but Too Far to Travel?
Authors: Shapiro Stanley J. , Burnett Sally-Ann
Published: January 2025

The Commentary that follows is a collective effort. The opening assessment of Dr. Batat's “Introducing” paper is the work of Stan Shapiro, now long retired, but over a span of fifty years first the product and then an unquestioning career-long practitioner of the kind of atomistic education that Dr. Batat considers incomplete and inadequate. From that perspective, he found much of merit in the Batat paper, not only in the advocacy of executing skills but also the presentation of educational outcomes as various forms of learning capitals and the emphasis on adult development. On the other hand, the complete absence of any discussion of the role of research and the governing assumption, one with which Stan could not accept, that academia would quickly and willingly adopt the revolutionary approach Dr. Batat advocates were seen as weaknesses in the paper. Stan's overall conclusion: the right direction but “too much, too soon.” But was there any midway position that could gain widespread acceptance at this time? This is where Dr. Burnett makes her contribution. She is currently the Senior Vice-President of the Acsenda School of Management, a privately owned, teaching-focused, and provincially regulated undergraduate degree-granting institution. Located in Vancouver, Canada, Acsenda has a student body made up almost entirely of international students. Shortly after joining Acsenda, Dr. Burnett was instrumental in that School adopting both the Learning Methodology and the Workforce Readiness model she describes in the closing paragraphs of this Commentary. This material is being presented as an example of the significant pedagogical change that could be made even within the framework of research-focused universities.
Examining the Ability of Digital Visual Art Engagement to Cultivate Empathy and Social Connection
Authors: Cotter Katherine N. , Mahlobo Christa T. , Smith Brittany , Niepold Suzannah , Rizzo Adam , Pawelski James O.
Published: January 2025

We aimed to impact social connectedness and perspective taking using visual art-based psychoeducational materials and skill-building exercises. Participants ( N = 381) were assigned to one of three conditions. Within the perspective taking condition, people took different viewpoints when viewing art. Within the social connection condition, people considered how art can help in reflecting on their relationships. Within the art education control, people focused on structural elements when viewing art. People completed 4 virtual gallery visits and measures of empathy, social connection, and loneliness at baseline, following each visit, and one-week post intervention. Participants reported their level of immersion and reflectiveness following each visit. Results suggest the conditions did not show changes one week post intervention; however, there were interesting findings post-visit. First, reflection was highest in the perspective taking condition, and the social connection condition showed increases in reflection across time. Second, the social connection condition showed reductions in loneliness.
Effective Clinical Approach for Treatment of Multiple Impacted Teeth in the Anterior Maxilla: An Orthodontic Perspective
Authors: Subbaiah Naveen K. , Srivastav Sukeshana , Chaudhari Prabhat Kumar , Duggal Ritu
Published: January 2025

This case report outlines the effective treatment of a multifaceted orthodontic case involving multiple impacted and supernumerary teeth and complete transposition in a 10-year-old girl. She presented with missing anterior teeth, an Angle’s class I molar relation on the left, Angle’s class II molar relation on the right, and various dental anomalies. On cone-beam computed tomography (CBCT) evaluation, the patient had vertically impacted four teeth (central incisors, right lateral incisors, and canine) and four supernumerary teeth. The treatment plan included surgical extraction of impacted teeth, orthodontically guided eruption, extraction of supernumerary teeth, and atypical extraction of #12, #24, #34, and #44 due to arch length tooth material discrepancy. #12 was extracted as there was palatal fenestration and had an open root apex. The spatial position and orientation of the impacted teeth were assessed using CBCT. The orthodontic treatment employed a rigid metal framework with NiTi coil springs for guided eruption. Interdisciplinary collaboration among orthodontists, dental surgeons, and other specialists, along with meticulous planning and controlled force application, was crucial. Satisfactory aesthetics, functional occlusion, and stability were obtained at the end of the treatment, demonstrating the effectiveness of orthodontic intervention in complex cases.
Otherworldly Application
Authors: Testa Bridget Mintz
Published: January 2025

NASA brings circadian-based LED lighting to the International Space Station
Higher Art
Authors: Schwirck Samantha
Published: January 2025

The University of Iowa's replacement for a flood-damaged building contains seven vertical cutouts that create light-filled interior pockets
Substance is subject is style: On the speculative poetics of Gillian Rose
Authors: Marks Gregory
Published: January 2025

This article proposes a reading of philosopher Gillian Rose's works as predominated by the question of literary style. In contrast to Rose's professed antipathy for the linguistic and structuralist turns in 20th-century philosophy, this article contends that her thought makes recourse to distinctions of literary form (i.e. poetics) to resolve problems of philosophical expression. The contours of this poetics are traced from Rose's first works on the respectively ‘ironic’ and ‘severe’ styles of Adorno and Hegel, through to her final published work and its experimentations with the formal limitations of philosophical writing. Following Hegel's theorisation of the ‘speculative proposition’ as a statement of formal difference belying a conceptual unity, Rose's poetic thought is designated as a speculative poetics, which seeks a stylistic unity that does not efface the non-identity of its terms.
Learning and Organisational Change in Regional Agencies of Telemedicine: Implications for the Mexican Case
Authors: Sampedro-Hernández José Luis
Published: January 2025

The aim of this article is to analyse the technological and organisational learning processes and their relationship with organisational and institutional changes in Mexican public hospitals that have implemented telemedicine systems. A qualitative research strategy has been followed by implementing an exploratory multiple-case-study approach. The fieldwork was conducted from July 2012 to June 2015 in seven regional agencies of telemedicine (RATM) of Mexico. General information for each RATM has been updated to 2021. The implementation and use of systems of telemedicine in clinics and hospitals around the world have influenced the efficiency and effectiveness of health services, but the effects are not direct or automatic. Health organisations go through phases of internalisation of technology and this implies the development of a knowledge base, learning processes and organisational and institutional changes. The processes of learning-by-doing, learning-by-implementing and learning-by-using explain the patterns of organisational and technological change. However, there are cultural and technical constraints that make these changes slow. A natural tension between the changes achieved and the prevailing resistances is present, so the role of leaders, the creation of scenarios that foster collaboration, trust and good communication among the members of the team, a knowledge base and learning processes are crucial.
The Pharmacological Research of Traditional Chinese Medicine and Herbal Remedies in the Treatment of Melanoma
Authors: Yan Shuang , Wang Yawei , Zeng Jing , Liu Dan , Qin Haichuan , Du Chengzhen , Xiang Qiao , Yang Li , Li Ling , He Yuxin
Published: January 2025

Background:

Melanoma is a highly invasive and metastatic malignant tumor, with pathogenesis involving multiple signaling pathways and transcription factors. Current treatments face significant challenges, including drug resistance, toxic side effects, and recurrence.

Purpose:

This review aims to evaluate the therapeutic potential of natural products in the treatment of melanoma and to identify the associated challenges and future research opportunities.

Methods:

A comprehensive literature search was conducted using PubMed and Web of Science to identify studies reporting on natural products with antimelanoma activity.

Results:

Natural products demonstrate diverse pharmacological activities, including antiproliferative, proapoptotic, and antimetastatic effects, highlighting their potential in melanoma treatment. However, challenges such as limited efficacy, safety concerns, and the lack of standardized formulations remain significant barriers.

Conclusion:

This review provides insights into the therapeutic applications of natural products for melanoma, discusses existing limitations, and proposes future directions, contributing to the development of effective and safe antimelanoma treatments.
Development and Validation of a Robust LC-MS/MS Method for Quantitation of a Novel Kinase Inhibitor, Ritlecitinib, in Rat Plasma: Application in Pharmacokinetic Study
Authors: Kumar Katari Pavan , Rao Areti Anka
Published: January 2025

Background

Ritlecitinib (RIT) is a novel kinase inhibitor with promising therapeutic applications in the treatment of autoimmune disease alopecia areata. Accurate quantification of RIT in biological matrices is essential for pharmacokinetic studies and drug development.

Objectives

This study aims to develop and validate a sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitation of RIT in rat plasma and to apply this method in a pharmacokinetic study.

Materials and Methods

A sensitive and selective LC-MS/MS method was developed in a AB Sciex QTRAP 5500 coupled with Shimadzu Prominence LC-20AD UFLC (ultra-fast liquid chromatography) System using an C18 column (Xselect HSS T3 2.5 µm, 2.1x150 mm) with a mobile phase consisting of 0.1% formic acid in high-performance liquid chromatography (HPLC) grade water and 0.1% formic acid in acetonitrile (70:30, v:v). RIT ( m/z 286.1 ↓ 105.7) and [ 13 C4]-ritlecitinib (internal standard, IS) ( m/z 290.1 ↓ 109.7) were detected in a positive mode by electrospray ionization (ESI) using multiple reaction monitoring (MRM) and extracted from rat plasma samples through protein precipitation We validated the method according to United States Food and Drug Administration (U.S. FDA) guidelines, assessing parameters such as linearity, accuracy, precision, selectivity, sensitivity, recovery and stability. The validated method was then applied to a pharmacokinetic study in rats following the administration of RIT.

Results

On rat plasma, the LC-MS/MS method has shown exceptional linearity across the concentration range of 5–100 ng/mL. The FDA’s approved standards of ±15% matched the accuracy and precision measurements. The matrix effect was negligible, and the mean recovery was about 93%, indicating that RIT was fully extracted from plasma. Different experimental conditions found RIT to be stable. RIT is quickly absorbed, with a peak plasma concentration (Cmax) of 43.82 ng/mL occurring 0.5–0.75 hours after the dose. It then drops in concentration in a way that is biexponential, with a half-life at the end of 1.5 hours.

Conclusion

A highly sensitive and specific LC-MS/MS method for quantitation of RIT in rat plasma was successfully developed and validated. The method was effectively applied to a pharmacokinetic study, providing critical data on the absorption and elimination characteristics of RIT in rats. This established approach may support additional preclinical pharmacokinetic investigations of RIT.
Benzoxazinone Derivatives as Antiplatelet: Synthesis, Molecular Docking, and Bleeding Time Evaluation
Authors: Nofianti Kholis Amalia , Ekowati Juni , Diyah Nuzul Wahyuning , Hakim Luqmanul
Published: January 2025

Background

The recurrence of atherosclerosis is still a global problem. Unfortunately, the drugs currently being used are reported to have resistance.

Purpose

To prevent the recurrence of atherosclerosis disease, this study developed benzoxazinone derivatives as an antiplatelet agent: 2-phenyl-3,1-benzoxazine-4-one (BZ1) and 2-(4′-chlorophenyl)-3,1-benzoxazin-4-one (BZ2).

Methods

The target compounds were synthesized through acyl nucleophilic substitution from acyl chloride and anthranilic acid using a base catalyst in triethylamine. This compound was then given to mice at three different doses to perform bleeding-time and clotting-time tests, using acetosal as a comparison. In silico, the binding energy between the test compound and the cyclooxygenase 1 enzyme was tested using Molegro Virtual Docker version 5.5 (MVD 5.5). The pharmacokinetic parameters were predicted using pharmacokinetics and chemistry through space mapping (pkCSM).

Results

The synthesis provided 83% yield. The biological assay at a dose of 20 mg/kg body weight (BW) BZ1 showed a higher bleeding time (361 s) than acetosal (324 s), whereas BZ2 was lower (179 s). The molecular analysis revealed that the compound had higher activity than aspirin. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) showed that the compound posed high intestinal absorption.

Conclusion

This research concluded that both of the synthesized compounds have the potential and prospective to be developed as antiplatelet agents.
Designing E-commerce Livestreams: How Product Presentation Duration Affects Sales?
Authors: Xie Si , Sharma Siddhartha , Mehra Amit
Published: January 2025

Livestream e-commerce has emerged as a novel way to promote and sell products. This channel differs from existing promotion channels like TV/online video advertising because viewers voluntarily consume the content on this channel and are highly engaged due to social interactivity with the livestreamer and other viewers. A key design aspect of product promotions is the duration for which a product is presented during a livestream session. In this article, we empirically study the impact of product presentation duration by analyzing a unique dataset from two of the largest livestream shopping platforms in China. We find that when the product duration is longer, product revenue is higher. However, as the average presentation time increases, the session revenue decreases. The role of presentation duration in driving sales may differ between official (single-brand) livestreams sponsored by brands and third-party (multi-brand) livestreams. On analyzing the heterogeneous effects between official and third-party livestreams, we find that the positive impact on product-level sales is largely driven by third-party livestreams. On the other hand, both official and third-party livestreams can improve session-level sales by reducing the average product duration in a session. Thus, in the context of third-party livestreams, we observe a tension between the incentives of the brands (advertisers) whose goal is to drive an individual product’s sales and third-party livestreamers whose goal is to maximize total sales in a session. Our findings have useful implications for the design of e-commerce livestreams.
Mesonephric-Like Adenocarcinomas, an Underdiagnosed Rare Type of Gynecological Malignancy Associated with Aggressive Clinical Behaviors: A Series of 4 Patients from Single Institution
Authors: Niu Shuang , Gwin Katja , Chen Jackson , Li Yan , Lucas Elena , Chen Hao
Published: January 2025

Mesonephric-like adenocarcinoma (MLA) is a newly recognized type of carcinoma that occurs in the uterus and ovaries. MLA exhibits distinct morphological and immunophenotypical features similar to those of mesonephric carcinoma of the cervix or vagina, with the majority of reported tumors containing KRAS mutations. MLA is exceedingly rare and appears to be associated with aggressive clinical behavior. Literature regarding the clinical behavior of MLAs remains limited. Here, we report four additional MLA patients with detailed morphological and immunophenotypical analysis, as well as clinicopathological and follow-up information. Additionally, molecular study was conducted on the ovarian MLA tumor and one uterine MLA tumor. Our findings support the observation that MLA is associated with an aggressive clinical course and poor clinical outcomes. Out of four tumors presented, 2 (50%) were at an advanced clinical stage, 3 (75%) presented with metastasis (including 2 (50%) with lung metastasis), and 2 (50%) patients died of the disease. MLA is often misdiagnosed as other types of gynecological carcinoma, as indicated in the literature and evidenced in our study, where 2 (50%) were initially misdiagnosed as low-grade endometrioid carcinoma in biopsy. Therefore, an integrated approach, including careful evaluation of the morphological and immunophenotypical features of the tumor, preferably with molecular confirmation, is critical for accurate diagnosis of this aggressive malignancy.
Aberrant Methylation of RUNX1 is Associated with the Pathogenesis of Autoimmune Pancreatitis
Authors: Kinugawa Yasuhiro , Uehara Takeshi , Iwaya Mai , Asaka Shiho , Nakajima Tomoyuki , Nagaya Tadanobu , Shimizu Akira , Ota Hiroyoshi
Published: January 2025

IgG4-related disease (IgG4-RD) is an autoimmune disease of unknown cause. RUNX1 is a transcription factor involved in immune responses, and its dysfunction leads to uncontrolled immune responses. We performed, to our knowledge, the first RUNX1 methylation analysis in type 1 autoimmune pancreatitis (denoted simply as AIP), a representative IgG4-RD. We conducted methylation array analysis on AIP samples using the Illumina Infinium MethylationEPIC array. We identified a potentially important RUNX1 methylation abnormality in AIP, which was further confirmed using the quantitative SYBR green methylation-specific polymerase chain reaction (QSG-MSP) method. Using immunohistochemistry, we analyzed RUNX1 expression in lymphocytes in 11 lymph nodes with AIP (LN-AIP) and 20 lymph nodes with pancreatic ductal adenocarcinoma (PDA; LN-PDA). LN-AIP and LN-PDA refer to lymph nodes from patients with AIP and PDA, respectively. All selected PDA patients lacked lymph node metastases. By array analysis, RUNX1 was more highly methylated in LN-AIP than in LN-PDA ( P = 0.0275). RUNX1 was also more highly methylated in LN-AIP than in LN-PDA by QSG-MSP validation ( P = 0.0331). Immunohistochemical analysis indicated that RUNX1 expression was significantly lower in LN-AIP than in LN-PDA ( P = 0.0250). Aberrant RUNX1 methylation and reduced expression may be characteristic of AIP. Further validation is warranted.
Distribution Characteristics in Clinical Phenotype and Immunohistochemistry of STK11 Adnexal Tumors: Case Report and Narrative Synthesis
Authors: Wu Xiaohan , Yu Shili , Jia Meng , Sun Ping-Li
Published: January 2025

STK11 adnexal tumors are recently named tumors of the female adnexal region, associated with Peutz-Jeghers syndrome (PJS). There is a lack of studies on the clinical phenotypes of PJS concerning the pathology and molecular characteristics of STK11 adnexal tumors. We searched for 781 relevant studies through PubMed and Web of Science, and preliminary statistical and grouping comparisons were made using the screened study data combined with our patient. A total of 25 patients with STK11 adnexal tumors (excluding tumors with no detectable STK11 alterations) were reported in 4 studies. The tumors were most common in middle-aged women (mean age of 39 years) and typically located at paratubal sites (76%). Nearly half of patients (45%) had PJS manifestations or molecular changes. Compared with sporadic (non-PJS) STK11 adnexal tumors, PJS-associated STK11 adnexal tumors were slightly larger in diameter (mean 12.6 cm vs 8.9 cm) and had a longer interval between first recurrences (median 19 months vs 7 months). Primary tumors with pelvic recurrence had a reduced keratin 7 positive rate and tended to grow in non-paratubal sites. However, overall, the clinicopathological characteristics of PJS-associated tumors and sporadic tumors were similar, as was the immunohistochemical expression of primary and recurrent tumors. More specimens and studies are needed to support these observations and further delineate the characteristics of STK11 adnexal tumors.
Robust fuzzy output feedback control for a magnetorheological semi-active air suspension system with time-delay and actuator saturation
Authors: Lu Jingyu , Wong Pak Kin , Li Wenfeng , Zheng Chenhui , Zhao Jing
Published: January 2025

Magnetorheological fluid (MRF) dampers have been utilized in semi-active air suspension (SAAS) due to their attractive advantages. This paper investigates a novel robust fuzzy output feedback controller for semi-active air suspension with MRF damper (SAAS-MRFD), considering time delay and actuator saturation. An aero-thermodynamics theory is first utilized to describe the nonlinear air spring. The damping force of the MRF damper is represented by a hyperbolic tangent model. The interval type-2 (IT-2) Takagi–Sugeno (T-S) fuzzy method is second employed to capture those nonlinearities of the air spring and MRF damper. Considering the difficulty to measure all states, a novel dynamic output feedback (DOF) controller is developed by an appropriate Lyapunov–Krasovskii function and the reciprocally convex technique with consideration of time delay, actuator saturation, and output constraints. The effectiveness of the proposed controller is validated by both simulation and a quarter-car test rig (QCTR). The results indicate that the proposed controller has better performance in vibration reduction than the recent similar controllers in the literature.
Continuous versus intermittent tacrolimus for graft-versus-host disease prophylaxis in pediatric hematopoietic stem cell transplantation patients (Tic Tac)
Authors: Asleson Demi , Carr Roxane , Rozmus Jacob , Kendrick Jennifer
Published: January 2025

Background

Tacrolimus is administered via a continuous or intermittent IV infusion to prevent acute graft versus host disease (aGvHD) in pediatric hematopoietic stem cell transplant (HSCT) recipients. Limited comparison data is available.

Objectives

The primary objective was to compare the proportion of therapeutic tacrolimus trough levels in the first 30 days post-stem cell infusion. Secondary outcomes were prevalence of aGvHD, intra-patient variability (IPV) and safety.

Study Design

This was a retrospective cohort study that included pediatric HSCT recipients between March 1, 2015 and October 31,2021 at BC Childrens Hospital. Adverse events were assessed using the Naranjo scoring tool.

Results

Overall, 60 transplants in 59 patients were included; n = 36 intermittent IV and n = 24 continuous IV. Median proportion of blood levels (intermittent and continuous) within 8–12 ug/L was 38% and 56%, respectively (p = 0.04). IPV was 33% and 31% and aGvHD was 39% and 38% in intermittent and continuous respectively. There was a higher proportion of adverse effects in the intermittent group with the exception of hypomagnesemia.

Conclusions

Continuous IV tacrolimus provided a higher proportion of levels within therapeutic range. Neither achieved therapeutic trough levels in more than 56% of transplants. However, there was large intra-patient variability in both groups.
A cognitive help or hindrance? A systematic review of cognitive behavioural therapy to treat anxiety in young people with autism spectrum disorder
Authors: Roberts K. , Rankin P. M.
Published: January 2025

Objective

Anxiety rates amongst autistic youth range from 11% to 84%. While Cognitive Behavioural Therapy (CBT) is an effective treatment of anxiety in neurotypical youth, there are concerns autistic youth lack the cognitive resources necessary to effectively engage with CBT. It is also unclear whether standard or adapted CBT is more effective. This review aims to compare the effects of standard and adapted CBT in the treatment of anxiety in autistic youth.

Methods

Articles were searched across three online databases. 24 articles were selected for final review. All articles were published between 2008 and 2024. Total sample size was 1,140 and participant age ranged from 4–18 years. Various designs, settings, and CBT formats were incorporated.

Results

When treating anxiety in autistic youth, standard CBT is effective although CBT adapted to accommodate the autism-related needs of the youth appears more effective, with gains maintained up to 26 months post-treatment. Statistical analysis was not significant.

Conclusions

Standard and adapted CBT are effective treatments of anxiety in autistic youth. To optimise outcomes, it may be important to consider the common cognitive styles associated with autism and adapt the therapeutic intervention accordingly. However, there is not yet statistical evidence for this hypothesis.
Children and divorce: A rapid review targeting cognitive dissonance, in the context of narrative therapy
Authors: Lie Ken Jie Christopher , Jessen Yramategui Joanne , Huang Richard
Published: January 2025

Today, for divorcing parents, the social norms of “good” parenting appear to impose obligations to “fight” for shared custody of their children. However, this may intensify conflicts experienced by their children in the form of cognitive dissonance. Authors conducted a rapid review to explore children’s experiences of divorce (ages three to 12 years old) in the context of narrative therapy, in order to uncover the mechanism of cognitive dissonance. Four databases of Scopus, PsychINFO, Family and Societies Studies Worldwide, and PubMed were searched for literature in the last 10 years. Results included 11 study articles, one policy brief, and one book chapter, representing the experiences of 1169 children from seven developed countries/regions. Our findings suggest four themes associated with cognitive dissonance, whereby the first three represent the formation of harmful perceptions of cognitive dissonance resulting from divorce. The fourth represents the children’s coping strategies to reduce their cognitive dissonance. We advocate that family mediators consider narrative therapy targeting cognitive dissonance as a means of repairing disruptions to family coherence. In this regard, we recommend that future research explore the consequences of children’s confrontation of their cognitive dissonance in narratives found to be prevalent in children’s experiences of divorce.
Internet addiction affects college students’ intuitive eating over physical activity: Evidence from multiple studies
Authors: Liu Kai , Gong Heli , Liu Xiaoying , Zhang Tianyue , Mei Songli
Published: January 2025

Intuitive eating is a key focus in health psychology and has been closely linked to negative emotions, particularly among college students. A study examining the protective and risk factors influencing students’ intuitive eating could be valuable in helping them manage their weight and improve their emotional well-being. We therefore examined the effects of physical activity and internet addiction. A total of two studies were conducted: a questionnaire survey and an ecological transient assessment. Ultimately, we found that physical activity did not influence students’ intuitive eating. However, we found that internet addiction negatively influenced college students’ intuitive eating, both in terms of immediate and short-term delayed effects. Using multiple studies, we found that physical activity was not a predictor of intuitive eating and that internet addiction had both immediate and short-term delayed effects on intuitive eating. Furthermore, there was no interaction effect between the two.
British history at Tate Britain post-Brexit: Rich, white men and space invaders
Authors: Hahn Catherine
Published: January 2025

In 2023, Tate Britain rehung its semi-permanent collections display as a revisionist history of Britain. This major curatorial project makes compelling storytelling. Its critically engaged approach opens British art and history to wider interpretations. At the same time, the display elevates rich, white men. Drawing on a range of theoretical literature from cultural studies, sociology and art history, this article considers how Tate Britain operationalises difference and hierarchy as a British inheritance post-Brexit. I argue that key areas early in the first section of the display, Historic and Early Modern British Art (1550 to 1930), augment a rich, white, male hegemony, against which ‘others’, people of colour, the working classes and (some) white women, are presented as what Nirmal Puwar calls ‘space invaders’. I explore how curatorial revisions and other display strategies – chronology, staging, portraiture and binaries – both disrupt and reinforce the hegemony. The article includes my drawings of key areas of the display, which guide my research.
Jews and Muslims in the 19th district of Paris: Together or apart?
Authors: Mayer Nonna
Published: January 2025

From an intercultural perspective, this article explores majority/minority and between minorities interactions, and revisits Allport’s contact theory, in a socially and ethnically diverse urban area hosting a large proportion of Jews and Muslims. The data comes from a telephone survey of a sample of inhabitants of the 19th arrondissement of Paris. Open and closed questions explore the symbolic social and political boundaries respondents construct between ‘us’ and ‘them’, and their patterns of sociability. Survey experiments with vignettes deal with more sensitive issues (reactions to circulating cartoons at school and police reactions to verbal assault, according to the ethnicity of the victim). The immediate social and ethnic surrounding of each respondent is reconstructed on the basis of census and ethnographic data. The results go against several common beliefs. Religion is not the only dimension of respondents’ identity; it intersects with social class, gender and generation. The relations between Jews and Muslims are not so much conflictual as ambivalent. Being minorities and feeling discriminated against as such brings them together. They both are more religious than the majority population, more traditional on sexual issues and more family-oriented, and most of them consider that Jews and Muslims have a common cultural heritage and should be united against discrimination. Nevertheless, there are friction points (Israeli-Palestinian conflict/the colonial past of France). Politically and socially Muslims are closer to the non-European immigrants, while Jews are closer to the French and the European-born ‘white’ population. Antisemitism is a clear taboo; anti-Jewish cartoons are seen as far more reprehensible than any other. But a majority of the sample, and Muslims a little more than average, see Jews as a ‘group apart’, and believe in the old stereotype about Jews having more influence, being more likely, for instance, to be helped by the police if needed.
Unveiling the safety profile of lecanemab: A comprehensive analysis of adverse events using FDA adverse event reporting system data
Authors: Ge Wukun , Yan Yingyan , Hu Yaoyao , Lin Shuainan , Mao Peizhi
Published: January 2025

Background

Lecanemab, a novel monoclonal antibody targeting amyloid-β, has shown promise in treating Alzheimer's disease. Comprehensive post-marketing safety data analysis is crucial to understand its real-world risk profile.

Objective

This study aimed to evaluate the safety profile of lecanemab using data from the FDA Adverse Event Reporting System (FAERS), with a focus on nervous system disorders and amyloid-related imaging abnormalities.

Methods

We conducted a disproportionality analysis using the FAERS database to evaluate the safety signals associated with lecanemab. Reporting odds ratio (ROR), proportional reporting ratio, empirical Bayesian geometric mean, and information component were calculated at both system organ class (SOC) and preferred term (PT) levels. Additionally, we performed a time-to-onset analysis using Weibull shape parameter estimation.

Results

Analysis at the SOC level revealed significant signals for nervous system disorders (ROR: 7.32, 95% CI: 6.69–8.00). At the PT level, strong signals were observed for amyloid-related imaging abnormalities, particularly those associated with microhemorrhages and oedema (ROR: 4122.81 and 3922.78, respectively). Headache was the most frequently reported adverse event (200 cases), followed by chills (107 cases) and fatigue (97 cases). Time-to-onset analysis showed a median time of 33 days (range: 1–1283) for all adverse events, with neurological events occurring slightly later (median: 42 days, range: 1–1260).

Conclusions

Our findings highlight a distinct safety profile for lecanemab, with a predominant impact on the nervous system and a notable association with imaging abnormalities. These results underscore the importance of vigilant monitoring and further research to optimize the risk-benefit profile of lecanemab in clinical practice.
Efficacy of music-based intervention for people living with dementia in an inpatient setting: A pilot study
Authors: Abeywickrama Neha , Miraval Mel N Ellul , Subramaniam Hari , Arshad Qadeer , Pollard Stephanie , Chauhan Geeta , Jussab Shifa , Mukaetova-Ladinska Elizabeta B
Published: January 2025

Background

Pharmacological treatment of behavioral and psychological symptoms of dementia is of limited benefit. The addition of non-pharmacological interventions is often essential for optimal symptom control. Music is a viable way to help patients communicate and improve their quality of life.

Objective

This study aims to find the most effective way to use music in a busy dementia ward.

Methods

17 inpatients (aged 63–93 years) with a clinical diagnosis of Alzheimer's disease and dementia took part over five weeks. Music lyrics presented via free-field speakers were individualized to personal preferences. Instruments (e.g., maracas) were used in some group sessions. We used the Neuropsychiatric Inventory Questionnaire (NPI-Q) and Music in Dementia Assessment Scales (MiDAS) to evaluate patients’ behavior before and after musical intervention.

Results

There was a significant difference in mean NPI-Q scores before and after the music intervention. Specifically, Delusion, Motor Disturbances, and Agitation scores were significantly reduced after music intervention. This was accompanied by significant improvements in Interest, Response, and Enjoyment of MiDAS items during specific intervals.

Conclusions

Clinical professionals can successfully deliver music-based intervention to inpatients with advanced dementia to help manage their behavioral symptoms in the short term. Music-based interventions’ use for inpatient wards must be further investigated as an economical and personalized non-pharmacological therapeutic tool for patients with dementia.
The architecture design of emergency logistics management system based on the Internet of Things
Authors: Ruiwei Guo
Published: January 2025

The Internet of Things (IoT) aims to connect intelligent products with network functions through both wireless and wired technologies, enabling the safe and efficient distribution of services across global networks, including computers, mobile phones, and other electronic devices. The emergence of network devices with communication, sensing, and actuation capabilities since 2005 has led to a wide range of applications, such as inventory management, environmental monitoring, and tracking moving objects. However, the progress of IoT technology is hindered by the lack of adequate infrastructure capable of supporting trillions of devices. This paper explores the role of radio frequency identification (RFID) sensor networks within the IoT architecture for logistics management, positioning these networks as key “network-enabled” devices. The study investigates the components of the system, which include the domain sensor name server (DSNS), sensor service publisher (SSP), historical database, and RFID sensors. The strategic and operational implications of IoT architecture in logistics management are analyzed, with a particular focus on emergency response scenarios. The findings highlight the potential of IoT to improve resource allocation, enhance situational awareness, and support real-time decision-making during critical operations. This research offers valuable insights into the scalability challenges and the strategic benefits of IoT in logistics management, particularly in emergency contexts where timely data can significantly influence outcomes.
Algorithmic progress in temperature monitoring of overhead network connectors: Fusion of deep learning models
Authors: Zhang Zhiheng , Song Lei , Zhu He , Wang Maomao , Zhang Yawen , Hu Yumin
Published: January 2025

This paper mainly studies the application of deep learning model fusion in temperature monitoring. The research aims to enhance the safety and reliability of power system operations. Given the limitations of traditional monitoring methods in assessing the temperature of overhead line connectors in complex environments, a new approach is proposed: the CNN-DQN algorithm, which combines Convolutional Neural Networks (CNN) and Deep Q-Networks (DQN). The method extracts spatial features of temperature data through CNN and inputs these features into a Markov decision process (MDP) model using DQN to learn and optimize connector temperature monitoring strategies. Experimental results show that the CNN-DQN algorithm has a success rate of 93% in temperature detection and early warning. Compared with traditional models, it has significantly improved accuracy, stability and robustness. This research provides a new and effective method for power system temperature monitoring.
Numerical study of deep steep riser with different buoyancy module configurations based on 3D co-rotational coordinate method
Authors: Huang Chen , Gu Jijun , Wang Shujiang , Gao Lei , Huang Jun
Published: January 2025

In ultra deep-water environments, deep steep riser (DSR) can optimize the ultra-high-tension loads caused by the weight of the riser. In this paper, the influence of the buoyancy factor and the length of the buoyancy section of flexible jumper on DSR under random wave action is calculated and analyzed by using the co-rotational coordinate method (CRCM). The dynamic model of DSR is established based on the CRCM. The kinematics are described by Rodrigues formula. Then the dynamic governing equation of DSR is established. The Newmark-β method is used to solve the equation. Then a numerical example is given to verify the accuracy of the model. Finally, the influences of buoyancy factor and length of buoyancy section of flexible jumper on DSR are studied through parameter analysis. The results show that the length of buoyancy section has greater influence on DSR. When the length of the buoyancy section reaches 200 m, the influence of random waves on the displacement and internal force of DSR is more intense. The results can be used as reference for engineering application of DSR.