bluuebunny/crossref_metadata_2025 huggingface dataset:
Current-sensitive Hall effect in a chiral-orbital-current state
Authors: Cao Gang , Zhang Yu , Ni Yife , Schlottmann Pedro , Nandkishore Rahul , De Long Lance
Published: September 2023

Chiral orbital currents (COC) underpin a novel colossal magnetoresistance (CMR) in ferrimagnetic Mn3Si2Te6 [1]. Here we report the Hall effect in the COC state which exhibits the following unprecedented features: (1) A sharp, current-sensitive peak in the magnetic field dependence of the Hall resistivity; (2) An unusually large Hall angle reaching up to 0.15 (comparable to the highest values yet reported); and (3) A current-sensitive scaling relation between the Hall conductivity σxy and the longitudinal conductivity σxx, namely, σxy ~ σxxα with α ranging between 3 and 5, which is both sensitive to external current and exceptionally large compared to α ≤ 2 typical of most solids. These anomalies point to a giant, current-sensitive Hall effect that is unique to the COC state. We argue that a magnetic field induced by the fully developed COC combines with the applied magnetic field to exert the greatly enhanced transverse force on charge carriers, which dictates the novel Hall responses. The COC Hall effect is unique, as it is generated and controlled via the interaction between intrinsic COC and applied external currents, which leads to novel transport phenomena of fundamental and technological significance and requires new physics for explanation.
Characterization and Expression Analysis of GLABRA3 (GL3) Genes in Cotton: Insights into Trichome Development and Hormonal Regulation
Authors: Wu Naisi , Lu Benyi , Cao Yaofen , Rong Junkang
Published: September 2023

GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) genes encode a typical helix-loop-helix (bHLH) transcription factors that mainly regulate trichome branching and root hair development, DNA endoreduplication, trichoblast size, and stomatal formation. The functions of GL3 genes have been poorly characterized in cotton crop. In this study, we performed genome-wide scans for GL3 and EGL3 homologs to better understand their potential roles in trichome and fiber development in cotton crop. Our finding revealed that Gossypium hirsutum, G. barbadense, G. arboreum, and G. raimondii had a total of 6, 6, 3, and 3 GL3s, unevenly distributed on chromosome 4, 4, 2, and 2, respectively. Gh_A08G2088 and Gb_A09G2187, despite having the same bHLH domain as the other GL3 genes, were not analyzed due to their remarkably short sequences and limited number of motifs they possess, potentially indicating a lack of functional activity. The phylogenetic analysis divided remaining 16 GL3s into three subfamilies (Group I-Ⅲ) closely related to A. thaliana. These 16 GL3s have a complete bHLH domain, encoding 590–631 amino acids, with molecular weights (MWs) ranging from 65.92–71.36 kDa. The GL3s within each subfamily shared similar gene structures and motifs, indicating conserved characteristics within their respective groups. Promoter element analysis revealed 27 cis-acting elements in the GL3 promoter region. These elements include those responsive to salicylic acid, abscisic acid (ABA), methyl jasmonate (MeJA), and gibberellin. The expression of GL3 genes was analyzed in 12 tissues of G. barbadense and G.hirsutum using the publicly available RNA-seq data. Gb_D11G0219, Gb_D11G0214, and Gb_D08G2182, were identified as relatively highly expressed across the tissues, and selected for hormone treatment and expression validation in G. barbadense. RT-qPCR results demonstrated that Gb_D11G0219 and Gb_D11G0214 expression levels were significantly altered after MeJA, GA, and ABA, treatment. Subcellular localization prediction revealed that most GL3 proteins were expressed predominantly in the nucleus, with a few localized in the cytoplasm and chloroplasts. Overall, this study lays the foundation for further functional validation of GL3 genes in cotton trichome formation and fiber development by identifying hormonal regulation patterns and probable sites of action. The results provide a basis to elucidate the roles and regulatory mechanisms of GL3 genes in the intricate process of cotton fibre and trichome development.
Ambient Noise Tomography and Machine Learning Models to Reveal Geothermal Structure in the Taupo Volcanic Zone
Authors: Chhun Chanmaly , Tsuji Takeshi
Published: September 2023

To reveal potential geothermal fluid flows and temperature distribution in the Taupo Volcanic Zone, North Island of the New Zealand Hikurangi subduction zone, we analyzed seismometer and well log data. First, we extracted Rayleigh phase velocity dispersion curves from ambient noise cross-correlation analysis and then estimated S-wave velocity models through 3D surface wave tomography. Second, we constructed the 3D temperature model derived from our machine learning models using 3D velocity and temperature log data. Faulted/fractured zones, which can host fluids or magma, led to significant reductions in S-wave velocity within the subsurface. As a result, our S-wave velocities were lower in existing geothermal reservoirs and through flow pathways (i.e., active fault zones), particularly within the NE-SW directional structure toward Lake Taupo. The most suitable 3D temperature model (or others) was obtained based on the Gaussian process regression model, compared to other models in all machine learning algorithms. High-temperature areas ranging up to 300 °C or more are consistent with flow paths through the structure. Our approach could contribute to the unrevealed geothermal structures and fluid flow pathways in this region.
Evaluation of the role of HIS-1 and HSP-70 genes in pathology and response to the drugs by antisense oligonucleotides in Leishmania major
Authors: Abdollahi Vahideh , Heydari Mahshid , Abdollahi Haniye , Shams Elaheh , Esboei Bahman Rahimi
Published: September 2023

Propose
Leishmaniasis is a protozoan disease that caused by Leishmania spp. with wide spectrum of manifestations. Researchers are currently unable to control and treat different types of leishmaniasis and efficient vaccine and drug are not available. This study is aimed to assess the pathological aspects and drugs susceptibility of L. major which received antisense oligonucleotides (ASO) against HSP-70 and HIS-1 gene.
Methods
In current experimental study, we describe the anti-leishmanial effect of ASO targeting the HSP-70 and HIS-1 genes that genes play roles in stage differentiation and antileishmanial drugs susceptibility using the L. major promastigote, amastigote and cutaneous leishmaniasis (CL) in mice, respectively.
Results
Our results revealed that the expression of the HSP-70 and HIS-1 genes was significantly decreased in group receiving ASO. The amastigote count in macrophage in group receiving HSP-70 ASO was significantly lower than other groups. The results of in vivo experiments indicated that in the group receiving HIS-1 ASO the size of CL lesion and the susceptibility to the glucantime were significantly lower and higher than other group, respectively.
Conclusion
The results of current study showed that ASO as a new technique in genetic manipulation can help the control and prevent of many diseases.
A Capacitive Antibacterial Dressing with Electrical Stimulation for Infected Wound Healing
Authors: Wang Hao , Zheng Ruizhu , He pengyu , Li Xiaoming , Shi Zhijun , Yang Guang
Published: September 2023

The formulation of an antibiotic-free antibacterial approach is imperative in circumventing escalating bacterial drug resistance. Electrical stimulation presents a viable therapeutic modality for such an approach. Nonetheless, obstacles persist in achieving efficacious sterilization with biosafe low-voltage electrical fields (EFs) and enduring antibacterial capabilities. In this study, we have devised a novel capacitive antibacterial dressing comprising polypyrrole-wrapped carbon cloth (PPy-CC) electrodes and a bacterial cellulose (BC) hydrogel separator. Subjected to 1V electrical stimulation for 10 minutes, the dressing attains high bactericidal efficiency (up to 99.97%) and enhanced activity against multidrug-resistant (MDR) bacteria (up to 99.99%). Its considerable electric capacity and rechargeability allow for repeated charging to achieve sustained sterilization. In vivo results demonstrate significant inhibition of wound infection and facilitated wound recovery in infected full-thickness defects in mouse models. This represents an antibiotic-free, physically-stimulated treatment modality for infected wounds with considerable potential for clinical application.
Olfactory misinformation provides refuge to palatable plants from mammalian browsing
Authors: Finnerty Patrick , Possell Malcolm , Banks Peter , Orlando Cristian , Price Catherine , Shrader Adrian , McArthur Clare
Published: September 2023

Mammalian herbivores browse palatable plants of ecological and economical value. Undesirable neighbours can reduce browsing to these plants by providing ‘associational refuge’, but they can also compete for resources. Here, we recreated the informative odour emitted by undesirable plants. We then tested whether this odour could act as virtual neighbours, providing browsing refuge to palatable tree seedlings. We found that protection using this misinformation tactic was equivalent to that provided by real plants. Palatable seedlings were 17-20 times more likely to be eaten by herbivores without virtual, or real, neighbours. As many herbivores use plant odour to forage, virtual neighbours could provide a novel practical management approach to help protect valued plants.
Evaluating the strengths and weaknesses of large language models in answering neurophysiology questions
Authors: Shojaee-Mend Hassan , Mohebbati Reza , Amiri Mostafa , Atarodi Alireza
Published: September 2023

Background: Large language models (LLMs), such as ChatGPT, Google's Bard, and Anthropic's Claude, demonstrate impressive natural language capabilities. Assessing their competence in specialized domains such as neurophysiology is important for determining their utility in research, education, and clinical applications.
Objectives:This study evaluates and compares the performance of LLMs in answering neurophysiology questions in English and Persian across different topics and cognitive levels.
Methods:Twenty questions spanning 4 topics (general, sensory system, motor system, and integrative) and 2 cognitive levels (lower-order and higher-order) were presented to the LLMs. Physiologists scored the essay-style responses from 0-5 points. Statistical analysis compared the scores at themodel, language, topic, and cognitive levels.
Results:Overall,the models performed well (mean score=3.56/5), with no significant difference between language or cognitive levels. Performance was the strongest in themotor system (mean=4.52) and the weakest in integrative topics (mean=2.1). Detailed qualitative analysis revealed inconsistencies and gaps in reasoning.
Conclusions: Thisstudy provides insights into LLMs’ capabilities and limitations in neurophysiology. The models exhibit competence in fundamental concepts but face challenges in advanced reasoning and integration. Targeted training could address gaps in knowledge and causal reasoning. As LLMs evolve, rigorous domain-specific assessments will be important to gauge progress.
Rotating shift work Is Associated with increased risk of thyroid carcinoma ： an ecological study of 178905 workers in 35 European countries between 2000 and 2015
Authors: Yang Yuping , Yan Wenting , Han Shanshan , Zhang Liwen , Xu Yan , Chen Qing
Published: September 2023

Objective:Previous studies have shown that circadian disruption can affect thyroid hormone levels, but whether it elevates the risk of thyroid cancer (TC) is still controversial. The present study investigates the relationship between rotating shift work (RSW) and the incidence of TC.
Methods:The prevalence of RSW in the 35 European countries from 2000 to 2015 was estimated based on the data of 89257 men and 81749 women of the European Working Condition Survey. The incidence of TC was obtained from the Global Burden of Disease database. We analyzed the relationship between the prevalence of RSW and the incidence of TC 5 years later (TC5). We used a mixed model with adjustment of country-specific GDP per capita, Volcanic region, age, Education attainment rate, obesity rate and occupational radiation exposure rate.
Results: The prevalence of RSW was significantly associated with the incidence of TC5 (β = 0.03 95%CI:0.01, 0.06, P=0.03). For a quartile increase in RSW, the incidence of TC5 increased by 0.18 per 100000（95%CI：0.05 per 100000,0.33 per 100000）. When separately analyzed in the two genders, we found an association between the two in women (β = 0.04, 95%CI: 0.01, 0.08, P=0.02), but not in men (β = 0.01, 95% CI: -0.03, 0.04, P=0.75).
Conclusion: Circadian disruption may be associated with an increase in the overall risk of TC, but it only seems to affect the occurrence of TC in women, not men. Further research is needed to verify the findings of the present study.
Radially symmetric solutions of a nonlinear singular elliptic equation
Authors: Hsu Shu-Yu
Published: September 2023

For any $\lambda\ge 0$, $2\le n\le 4$ and $\mu_1\in\mathbb{R}$, we will prove the existence of unique radially symmetric solution $h\in C^2((0,\infty))\cap C^1([0,\infty))$ for the nonlinear singular elliptic equation $2r^2h(r)h_{rr}(r)=(n-1)h(r)(h(r)-1)+rh_r(r)(rh_r(r)-\lambda r-(n-1))$, $h(r)>0$, in $(0,\infty)$ satisfying $h(0)=1$, $h_r(0)=\mu_1$. We also prove the existence of unique analytic solution of the about equation on $[0,\infty)$ for any $\lambda\ge 0$, $n\ge 2$ and $\mu_1\in\mathbb{R}$. Moreover we will prove the asymptotic behaviour of the solution $h$ for any $n\ge 2$, $\lambda\ge 0$ and $\mu_1\in\mathbb{R}\setminus\{0\}$.
AMS 2020 Mathematics Subject Classification: Primary 35J70, 35J75 Secondary 53C21
Promoted wheat straw degradation on a composite microbial system
Authors: Zhou Yuheng , Yang Yingtao , Wang Xiaohui , Deng Hui
Published: September 2023

The improvement of lignocellulosic fermentation efficiency via a composite biological system incorporating multiple strains holds immense potential for various applications. In this study, we used Bacteroides cellulosolvens, Escherichia coli and Alcaligenes faecalis to construct a composite microbial system (CM), which has good degradation ability to lignocellulose. Degradation conditions were optimized and possible mechanisms during the degradation process on this composite microbial system were further studied. Research results indicated that the degradation rates of lignin, cellulose and hemicellulose were 40.43%, 33.19% and 42.69% respectively under certain conditions (temperature at 37 ℃, pH at 6.0, solid-liquid ratio at 8% and culture time over 312 h. The construction of the combination bacteria significantly enhanced the degradation ability of lignocellulose and showed a good correlation and coordination mechanism.
Digital Footprint of the Xishu Garden: A Case Study of the San Su Shrine Digital Preservation
Authors: Li Guo , Wenjing Ma , Deshun Zhang , Xueqian Gong , Zhigao Zhai , Mengjia Li
Published: September 2023

The Chinese Classical Garden is an important World Cultural Heritage site. The incorporation of digital recording methods in its preservation is an efficacious approach to safeguarding its cultural heritage value. Using the San Su Shrine as a case study, the theoretical framework of landscape informatics is employed in this study to demonstrate the application of 3D laser scanning and unmanned aerial vehicle (UAV) photography technologies in digital conservation research. The objective of this study is to acquire data and construct a three-dimensional (3D) point cloud model. This study employs two-dimensional mapping and 3D real-scene modelling to conduct feature extraction and quantitative analysis in three key areas: garden layout, commemorative items, and narrative spatial units. A research strategy is developed that focuses on the preservation of legacy gardens using digital means. The technical aspects and benefits associated with the recording, analysis, preservation, and restoration of the Xishu Garden are discussed.
Prognostic value of lymph node distribution after laparoscopic colectomy with Japanese D3 dissection
Authors: Noda Keisuke , Tominaga Tetsuro , Nonaka Takashi , Ono Rika , Oishi Kaido , Takamura Yuma , Ishii Mitsutoshi , Hisanaga Makoto , Takeshita Hiroaki , Oyma Shosaburo , Ishimaru Kazuhide , Nagayasu Takeshi
Published: September 2023

Purpose: Positive pathologic lymph nodes in colorectal cancer represent an important prognostic indicator. Whether lymph node distribution or the number of metastatic nodes is more strongly associated with survival prediction remains controversial.
Methods: Among 3449 colorectal cancer surgeries performed at Nagasaki University Hospital and five affiliated institutions from April 2016 to March 2022, we investigated 604 patients who underwent laparoscopic radical resection and were diagnosed with pathological Stage III cancer. Patients were divided into two groups according to whether they had central vessel metastasis (LND3 group, n=42) or not (LND1/2 group, n=562). After adjusting for background factors using propensity score matching, the LND3 group included 42 patients and the LND1/2 group included 40 patients. Patient background characteristics and prognosis were compared between these two groups.
Results: Before matching, frequencies of right-side colon cancer (64.3% vs 38.1%, p=0.001), multivisceral resection (11.9% vs 4.4%, p=0.039), clinical N2 status (40.5% vs 22.6%, p=0.032) and pathological N2 (73.8% vs 22.6%, p<0.001) were all greater and number of lymph nodes retrieved was higher (24 vs 19, p=0.042) in the LND3 group. After matching, no differences in any clinical factors were evident between groups. Five-year RFS (44.8% vs 77.1%, p=0.004) and OS (43.1% vs 83.2%, p<0.001) were worse in the LND3 group. Adjuvant chemotherapy improved RFS (adjuvant chemotherapy (+) vs adjuvant chemotherapy (-): 62.1% vs 27.7%, p=0.047) in the LND3 group.
Conclusion: LND3-positive patients show poorer prognosis than LND1/2 patients and should be treated with an appropriate perioperative treatment strategy.
Genomic Profiling Reveals Intraspecific Divergence and Interspecific Diversity in Allium cepa L.
Authors: Lekshmi Narayana Chellaiya Johnson Packia , Brindha Johnson Raja , Mahamuni Duraisamy , Rajesh Ramasamy
Published: September 2023

Evolution of genus is accompanied by ecological diversification. The majority of species grow in open, sunny, rather dry sites in arid and moderately humid climates. However, Allium species have adapted for many other ecological niches. Classical approaches for the identification of Allium cultivars are based on morphological traits. The assessment of these traits is difficult and their evaluation can be subjective considering that most of these cultivars are closely related. Hence, this study of Internal Transcribed Spacer (ITS) sequencing and four barcoding regions, matK, rbcL, trnH-psbA, trnL and Inter Simple Sequence Repeats (ISSR) were researched in onion, Allium cepa L. (Alliaceae) collected from three different cultivation sites. The results established noticeable hereditary divergence among the three cultivars. In ITS and matK, BDUT 1453, BDUT 1454 and BDUT 1455 were independent of each other and formed three clusters. In rbcL, BDUT 1453 formed an independent cluster from the cluster of BDUT 1454 and BDUT 1455. But in trnH-psbA, BDUT 1454 formed an independent cluster and BDUT 1453 and BDUT 1455 were closely placed whereas trnL showed all the three forming a cluster wherein BDUT 1453 and BDUT 1454 were placed closely in a sub-cluster. In ISSR, BDUT 1454 and BDUT 1455 formed a single cluster and BDUT 1453 diverged from it. Even though the tested cultivars belong to the same species they showed genetic divergence among themselves.
The predictive value of total bilirubin for acute appendicitis in retrospect
Authors: Saad Hassan A. , Eraky Mohamed E. , El-Tahe Ahmed K , Riad Mohamed , Farid Mohamed I , Sharaf Khaled
Published: September 2023

Objective
The present study aimed to examine the clinical importance of preoperative total bilirubinemia in patients with acute appendicitis and to determine whether it has any practical application for predicting severe appendicitis.
Methods
A retrospective analysis of appendicectomies was performed at one hospital ( 636 cases of acute appendicitis presenting to the emergency department between December 2019 and January 2023). Using multivariate analysis, we examined predictive data for complex (perforated or gangrenous) appendicitis, including demographics, sex, white blood cell count, degree of C-reactive protein (CRP) elevation, high-temperature peritoneal signs and indicators, and total bilirubin levels.
Results
Those with total bilirubin (> 1.1 mg/dL), high C-reactive protein (CRP) levels (> 0.5 mg/dL), positive peritoneal irritated symptoms, and temperature (> 37.3 C) had considerably higher rates of acute appendicitis. Age (> 64 years), hyperbilirubinemia, high CRP levels, and fever (odds ratios of 3.36, 1.75, 7.61, and 2.43, respectively) were identified by multivariate analysis as associated risks for complex appendicitis. This is particularly true for those under 65 years of age.
Conclusions
High temperature, elevated CRP level, and high total bilirubin level were good predictors of acute appendicitis, especially in patients younger than 65 years; however, total bilirubin level was a more precise indicator.
Reversal of cellular senescence and insulin resistance in Skeletal muscle cells, via p38 mitogen-activated protein kinase inhibition
Authors: Rana Karan Singh , Raja Farah NS , Marwah Mandeep K , Dias Irundika , Brown James E , Bellary Srikanth
Published: September 2023

Aims/hypothesis; Increased accumulation of senescent cells with ageing is associated with reduced ability of insulin-target tissues to utilise glucose, resulting in increased insulin resistance and glucotoxicity. We investigated the role of senescent-associated secretory phenotype (SASP) within C2C12, skeletal muscle cells on glucose homeostasis and if such effects can be reversed by blocking pro-inflammatory pathways. Methods; C2C12 myotubes were treated with 40% conditioned media from senescent fibroblasts. Indirect glucose uptake was measured, along with glycogen content and cell viability. The effect of SASP on the generation of reactive oxygen species and mitochondrial density in C2C12 myotubes was measured using Mitosox and Mitotracker staining. To assess the effect of blocking pro-inflammatory pathways on cellular senescence, above experiments were repeated with a p38 inhibitor and a western blot was completed using antibodies to NF-κβ in the presence and absence of conditioned media from senescent cells. Results; 40% SASP treatment significantly decreased glucose utilisation and glycogen storage, without reducing cell viability within mature C2C12 myotubes (p = < 0.0001). 40% SASP was successful in inducing oxidative stress and increased mitochondrial density following 48 hours of incubation (p = < 0.0001). Blocking NF-κβ, the pro-inflammatory signalling cascade restored glucose utilisation (p = < 0.01) despite the presence of 40% SASP. Co-incubation of 40% SASP with an NF-κβ inhibitor eliminates excessive reactive oxygen species production and restored mitochondrial density to levels comparable to control treatment. The role of NF-κβ in propagating cellular senescence was confirmed by increased p50 protein expression in C2C12 myotubes cultured in 40% SASP for 48 hours. Conclusion; Our study shows changes in glucose homeostasis in senescent cells is likely to be mediated through SASP and this effect can be reversed by blocking proinflammatory pathways. Targeting these pathways to reduce inflammation could be a potential treatment for individuals experiencing age-related insulin resistance.
Preparing the implementation of peer support work in FACT: Exploring perspectives of managers
Authors: Johansen Kirsten Kjaer , Lerbaek Birgitte , Slade Mike , Castelein Stynke , Jørgensen Rikke
Published: September 2023

Purpose
The purpose of this study was to understand the point of departure for peer support workers in an organization new to working alongside with peer support workers as equal colleagues.
The aim of this study was to explore the perspectives of Flexible Assertive Community Treatment managers on preparation and employment of peer support workers, and how from a manager’s perspective, the non-peer professionals were prepared to work alongside with peer support workers.
Methods
This qualitative study was based on semi-structured interviews with all Flexible Assertive Community Treatment managers (n = 5) in the community mental health care in the North Denmark Region. The analysis was conducted with an inductive approach to content analysis.
Findings
The study revealed three themes: 1) An exploratory but energy loaded process - deciding to implement Flexible Assertive Community Treatment and employ peer support workers, 2) Paving the road while walking - preparing employment of peer support workers, and 3) Uncertainty about the “how” and the “what” – preparing non-peer professionals for collaborating with peer support workers. The themes suggest an exploratory and unstructured implementation process.
Conclusion
Our findings reveal that lack of structure and specific activities during implementation may compromise staff wellbeing, expressed as feeling insecure about own professional role, and lacking the sense of readiness to embrace peer support workers as colleagues. Applying an implementation framework and addressing the literature on barriers and facilitators may help limit the barriers towards employment of peer support workers and may promote successful implementation.
Diagnostic accuracy of the breast MRI Kaiser Score in suspected architectural distortions and its comparison with mammography.
Authors: Aslan Ozge , Oktay Aysenur
Published: September 2023

Suspicious architectural distortions are an elusive finding in breast cancer diagnosis. This study aimed to evaluate the diagnostic accuracy of the Kaiser score for suspicious architectural distortions observed on mammography and compare it with the BI-RADS score of the lesion. Mammograms performed between January 2013 and March 2023 were retrospectively analyzed for the presence of suspicious architectural distortion. Forty-one patients, who had at least 1 year of radiological follow-up or pathology results, and underwent breast MRI, were included in the study. Mammography findings and the BI-RADS category of the lesion were assessed. MRI findings were assesed and Kaiser scoring was performed according to the tree flowchart. Ninety-one percent of the enhanced lesions had a Kaiser score of 5 and above. In the diagnosis of malignancy, the Kaiser score yielded an accuracy of 78.05% and an AUC of 0.833 by ROC analysis. A statistically significant correlation was observed indicating that a malignant diagnosis was more prevalent in patients with a Kaiser score of 5 and above (p = 0.030). The combined utilization of mammography findings and the evidence-based Kaiser score in suspected architectural distortions provides more accurate results in the differential diagnosis of breast cancer.
Evaluation of electrocardiogram parameters and heart rate variability during blood pressure elevation by phenylephrine in cirrhotic rats
Authors: Ketabchi Farzaneh , Khoram Mohammadreza , Dehghanian Amirreza
Published: September 2023

Cirrhotic cardiomyopathy is a myocardial disease that may go undetected in the early stages due to peripheral vasodilatation. The aim of the study was to evaluate the electrocardiogram (ECG) and heart rate variability (HRV) after raising blood pressure by phenylephrine injection in rats with liver cirrhosis. Twenty male Sprague-Dawley rats were divided into the Sham and common bile duct ligation (CBDL) groups. After 44 days, animals were anesthetized and the right femoral artery and vein catheterized. After a steady-state period, a bolus injection of phenylephrine (PHE, 10 µg/µl/IV, baroreflex maneuver) was followed by a slow injection of PHE (100 µg/ml/5min/IV, sustained maneuver). Rapid and slow injections of PHE resulted in a greater increase in MAP and a weaker bradycardia response in the CBDL group than in the sham group. ECG analysis showed increased QT, QTc, JT, and T peak to T end in the CBDL group, which did not change after PHE injection. On the other hand, the parasympathetic indices of the HF band and RMSSD, and the sympathetic index of the LF band were lower in the CBDL group than in the sham group after PHE injections. ECG data indicated prolonged ventricular depolarization and repolarization, independent of the level of blood pressure in cirrhosis, whereas the parasympathetic and sympathetic components of HRV decreased regardless of the duration of the elevated blood pressure. We suggest HRV analysis can provide a useful approach in evaluating cardiac dysfunction during increasing blood pressure in cirrhosis.
The Distribution of Spatial Liquefaction with different interpolation methods using GIS: A case in Bantul Region, Indonesia
Authors: Haifani Akhmad Muktaf , Nirwansyah Anang Widhi , Suntoko Hadi , Alimah Siti
Published: September 2023

Liquefaction Potential Index (LPI) is a technical standard for assessing an area that can become liquefied, representing the accumulation of damaged soil layers. This study used interpolation techniques to visualize the distribution of potential liquefaction in an area, which includes Topo to Raster, Spline, Inverse Distance Window, and Kriging. This interpolation technique compares the most effective methods for describing the LPI distribution. This study's results show that the Topo to Raster interpolation technique is assumed to be the most effective in explaining the LPI distribution by considering the correlation between LPI and amax for the Bantul area. In the validation test, the Topo to Raster correlation results produced the optimum R2 value (0.769) among the three other interpolation techniques, 0.476 (RMSE) and 0.911 (MAE). Pearson's test showed that the Topo to Raster produced a strong relationship between amax and LPI of 0.863. Visualization of the 2D LPI distribution is essential to mitigate the liquefaction so that this approach can minimize the potential damage to the foundation design and civil building structures.
Life Cycle Assessment of Wooden Glamping Structures: A Carbon-Positive Solution by Innovation in Forest-Based Industry
Authors: Sebestyén Tihamér Tibor
Published: September 2023

This paper examines the environmental impact of incorporating wood into glamping structures, revealing a significant net carbon sequestration effect. The wood used in these structures, sequestering 36.83 metric tons of CO2, surpasses the carbon emissions associated with the entire glamping life cycle, totaling 9.97 or 11.72 metric tons of carbon. One wood-based structure can store about 25 metric tons of carbon for 50 years. This noteworthy finding highlights how sustainably harvested wood can operate as a carbon sink, balancing carbon emissions produced throughout raw material procurement, manufacture, building, and use. The paper evaluates each step of manufacturing by life cycle assessment, applying the ‘cradle to grave’ approach. The assessment aims to identify possibilities for CO2 emission reduction in the supply value chain, developed horizontally in a region as well as vertically for glamping production among 7 Romanian companies. Such carbon-offsetting attributes offer a valuable tool in the fight against climate change, aligning with global sustainability goals. To maximize these benefits, sustainable sourcing and management of wood resources are essential, as is the adoption of carbon-positive design principles that prioritize carbon storage. Beyond carbon neutrality, this scenario presents an opportunity to educate stakeholders and guests about the significance of sustainable construction in mitigating climate change and the importance of material choices with low carbon footprints, carbon neutrality and environmental stewardship. The results of the study are presented in the context of other papers that have been written and published internationally, sharing the lessons learned from production and resource management techniques, with the aim of CO2 neutrality production from forest-based industry for tourism on the horizon.
A family of linearly weighted-θ compact ADI schemes for sine-Gordon equations in high dimensions
Authors: Zhang Qifeng
Published: September 2023

This paper proposes a family of weighted-$\theta$ high-order ADI schemes forsine-Gordon equations in high dimensions in combination of the discretization of a three-level linearized schemein temporal direction and a classical compact difference scheme in spatial direction.The uniquely solvability, convergence and stability of the differencescheme in two dimensions are strictly proved with the convergence order four in space and order two in time under the $L^\infty$-norm.More remarkably, the present numerical scheme can be extended tocope with the three-dimensional case feasibly. Several benchmark problems in two and threedimensions verify theoretical results and the capacity in simulating the dynamic behavior of ring solitons.Specially, several novel numerical isosurfaces in three dimensions are presented for the first time.
Mathematics Subject Classification (2020) 65M06 · 65M12
Big Data Analytics and Exports - Evidence for Manufacturing Firms from 27 EU Countries
Authors: Wagner Joachim
Published: September 2023

The use of big data analytics (including data mining and predictive analytics) by firms can be expected to increase productivity and reduce trade costs, which should be positively related to export activities. This paper uses firm level data from the Flash Eurobarometer 486 survey conducted in February – May 2020 to investigate the link between the use of big data analytics and export activities in manufacturing enterprises from the 27 member countries of the European Union. We find that firms which use big data analytics do more often export, do more often export to various destinations all over the world, and do export to more different destinations. The estimated big data analytics premia for exports are statistically highly significant after controlling for firm size, firm age, patents, and country. Furthermore, the size of these premia can be considered to be large. Successful exporters tend to use big data analytics.
JEL classification: D22, F14
Impact of Proton Pump Inhibitors on Kidney Function and Chronic Kidney Disease Progression: A Systematic Review
Authors: Parmar Mihirkumar P. , Kaleem Safa , Samuganathan Periyaiyadever , Ishfaq Lyluma , Tejaswi Anne Sai Nitya , Patel Yashaswi , Sai Bollu Sashank , Venugopal Vishal
Published: September 2023

Aim:
The aim of this systematic review is to comprehensively assess and analyze the impact of proton pump inhibitors on kidney function and their potential role in the progression of chronic kidney disease. Through a meticulous examination of available literature, we aim to provide a clear understanding of the relationship between proton pump inhibitor use and kidney health, shedding light on potential risks, benefits, and contributing factors. Ultimately, this research aims to inform healthcare professionals and patients alike about the implications of proton pump inhibitors on kidney function, facilitate informed medical decisions, and improve patient care.
Methods:
We used the following medical subject headings (MeSH) terms with keywords like "irritable bowel syndrome" and "kidney injury" to gather data from the National Library of Medicine (PubMed), PubMed Central (PMC), and Google Scholar. Articles from the last 10 years, 2013 to 2023, were gathered for this systematic review.
Results:
The results indicate a complex relationship between proton pump inhibitors and kidney function, as well as the progression of chronic kidney disease.
Conclusion:
In the end, this systematic review shows that there is a link between long-term use of proton pump inhibitors and a higher risk of kidney problems. Patients and healthcare providers should weigh the benefits of proton pump inhibitor therapy against potential risks, especially in individuals with pre-existing kidney conditions, and consider alternative treatment options when appropriate. Regular monitoring of kidney function in proton pump inhibitor users may also be advisable to ensure early detection and management of any adverse effects.
The Perceived Impact of A Post-Secondary Education Program On Kenyan Catholic Sisters' Understanding of Their Lives As Women Religious
Authors: Lopatofsky Tara M.
Published: September 2023

Kenyan women religious serve in ministries that provide essential aid in their communities.  These ministries include vital positions in the fields of education, healthcare, social work, finance, and agriculture, among others.  However, approximately 80% of women religious in sub-Saharan Africa lack the post-secondary education necessary to adequately meet the evolving demands of their ministries (Wakahiu & Shaver, 2015).  For this reason, women religious in Kenya have been provided an opportunity to participate in a uniquely delivered, fully funded, post-secondary education program.  Although two qualitative studies had previously been conducted on this post-secondary education program, none had addressed the impact of the program on the participants' understanding of their lives as women religious.  As a result, this qualitative study endeavored to answer the questions:  Has participation in the program transformed Kenyan sisters' understanding of their lives as women religious?  And, has participation in the program influenced how Kenyan women religious view themselves in their ministries?  In-person interviews with program participants and staff (N = 17), as well as document reviews, were conducted in order to effectively answer these questions.  Upon analysis, three themes were revealed, including enhancement of ministry abilities (academic, professional, congregation strengthening, spiritual), empowerment (self-confidence) and relational engagement (social interaction, self-awareness, leadership).  From these themes, the concept of servant leadership emerged as the ultimate perceived impact of the post-secondary education program on Kenyan Catholic sisters' understanding of their lives as women religious and view of themselves in ministry.
Alternatif Solusi Mengontrol Cahaya Alami pada Desain Bangunan Komersial
Authors: Sanitha Onie D. , Fransisco Theo , Iashania Yunida , Kristianti Novera
Published: September 2023

Title: Alternative Solutions to Control Heat Radiation in Commercial Building Design; Case Study: Commercial Buildings In Bukit Keminting, Palangka Raya City
 
A building envelope is a component that protects against environmental influences outside the building that are not expected to be a solution in controlling heat radiation and sunlight. However, the shops in Bukit Keminting, Palangka Raya, have challenges. In addition to its function as a commercial building with essential criteria like visibility aspect, the position of the storefront along the road also directly faces the sunset. This causes the store to receive heat and glare from 2 p.m. to 5 p.m. Using web-based software development from AndrewMarsh.com. This study focuses on effective shading devices for stores in Bukit Keminting Palangka Raya in controlling heat radiation without eliminating the vital aspect of visibility for commercial buildings. The software analysis shows that a highly flexible device is the most suitable solution. The type of shading device with these properties is the type of external Venetian blind, which can be adjusted according to the direction of the incoming light, which changes every month.
Variación de la navegabilidad de un robot skid steer frente a cambios en la morfología de los remolques acoplados
Authors: García Jesús Marcey , Martínez Delgado Jorge Eliezer , Yánez Amestica Pedro Abraham
Published: September 2023

El efecto que produce el acoplamiento de remolques sobre la navegabilidad de robots móviles cuando se desplazan sobre superficies inclinadas no ha sido muy estudiado. Por tanto, en esta investigación se estudia la influencia de algunos factores relacionados con la morfología de los remolques sobre la estabilidad al vuelco, la capacidad de direccionamiento y la propensión al deslizamiento en un robot móvil Skid Steer que posee dos remolques acoplados. Específicamente y con base en resultados de simulación, se consideraron los siguientes factores: tipo de articulación en el acoplamiento, cantidad de cuerpos acoplados, longitud de los remolques y orientación relativa entre los remolques y el tractor. Esto, con el propósito de brindar a los desarrolladores de sistemas robot – remolques, parámetros orientativos que les permita configurar estos sistemas de manera más eficiente, y lograr un mejor desempeño en cuanto a la navegabilidad se refiere.
Diseño, construcción e implementación de material educativo multimedia para el curso de gestión del riesgo de la Universidad de los Llanos
Authors: Agudelo Oscar Manuel , Beltrán Rueda Lina Patricia , Ospina Ladino Maria Cristina
Published: September 2023

La Especialización en Gestión de Proyectos concebida bajo la modalidad a distancia, cuenta con la plataforma Moodle, para la generación de mediaciones pedagógicas, pero carece de material educativo multimedia para potenciar el trabajo independiente y facilitar el proceso de enseñanza-aprendizaje en los estudiantes. En este sentido, se plantea el proyecto ¨Diseño y construcción de materiales educativos digitales para el curso de gestión del riesgo” debido a que es un área transversal a todas las profesiones. Para el desarrollo de los materiales se utilizó el marco de trabajo Scrum, con el apoyo de un experto en la temática; se estableció un guión de contenido multimedia utilizando como guía el PMBOK. El material digital educativo se implementó en Villavicencio, y fue evaluado por estudiantes y profesores a través de una encuesta que evalúa los componentes de contenido, interfaz y navegabilidad, y proceso pedagógico, la cual arrojó resultados satisfactorios con un nivel de aceptación “de acuerdo” según la escala de Likert. El proyecto genera nuevos ambientes de aprendizaje que se traducen en un recurso práctico para los estudiantes y docentes de programas de pregrado y posgrado de la Universidad y se constituye en material disponible para ser utilizado en cualquier momento y lugar.
Integration of the software engineering theory and the quality function deployment methodology for supporting the measurement of the state of progress in software projects
Authors: Castro Luis Fernando , Espitia Peña Esperanza
Published: September 2023

A fundamental practice to fulfill the objectives in a software project, is to measure its state of progress so that corrective actions can be taken timely. Most of approaches supporting measurement processes are focused on describing techniques to deal with these measurements from a project management perspective. However, these approaches lack of strategies that facilitate an adequate integration, understanding and application by professionals in software development area. In addition, the lack of rigor of such proposals hinders the establishment of common practices and give rise to unreliable results. This paper is aimed at providing an approach that satisfy the need of using frameworks standardized and easily adopted in order to support the measurement in the software development. To do this, we use the elements provided by SEMAT (Software Engineering Method and Theory) and the procedures established by QFD (Quality Function Deployment) by generating a proposal which includes a representation standardized and a method to analyze the needs of measurement from customer perspective. Also, a mapping review and a study based on interviews intended to assure the reliability of the findings exhibited in this paper were done.
Evapotranspiración en humedales construidos de descarga cero con cubierta para tratamiento de aguas residuales
Authors: Vega Serrano Haimar Ariel , Almeira Ospina Juan Ernesto
Published: September 2023

Se han propuesto alternativas para el manejo y tratamiento de los residuos del beneficio del café sin embargo han resultado ser muy complejas, costosas y no han sido adoptadas por los productores del grano o los efluentes no cumplen con los requerimientos de la normatividad vigente en el país. El objetivo de la investigación fue establecer la evapotranspiración (ET) y los coeficientes de cultivo (Kc) de tres especies de plantas comunes en la región cafetera: Arundo donax, heliconia fire opal y brachiaria mutica para ser utilizadas en los humedales construidos con descarga cero como alternativa para el tratamiento de aguas residuales del beneficio del café. Se construyeron tres unidades en recipientes plásticos de 100 litros en las cuales se plantaron las especies. Tres meses después de establecidos los cultivos se iniciaron las mediciones del consumo diario de agua en cada humedal y se calculó la ET y la evaporación de referencia ET0. Arundo donax fue la especie con la mayor ET con un promedio de 8.6±4.2 mm/d, logrando un incremento del 83% respecto de la ET0 la cual fue de 4.7±0.5 mm/d. El Kc promedio para la caña fue 1.8±0.8 siendo el mayor.
Using Machine Learning Algorithms for Neurodegenerative Disease Gait Classification
Authors: Cárdenas Torres Andrés Mauricio , Ealo Otero Luis Carlos , Uribe Perez Juliana , Gomez Gomez Beatriz Liliana
Published: September 2023

La detección de los síntomas de las enfermedades neurodegenerativas suele producirse en las últimas fases de la enfermedad, por lo que una detección temprana ayudaría a mejorar la calidad de vida del paciente. La base de datos PhysioNet proporciona información sobre la biomecánica de pacientes con la enfermedad de Parkinson (EP), la esclerosis lateral amiotrófica (ELA) y la enfermedad de Huntington (EH). En este trabajo se utilizan datos espacio-temporales para medir el coste energético y la densidad espectral de potencia en estas patologías. Se utilizan técnicas de c-medias difusas, algoritmo de aprendizaje para el análisis de datos multivariados - LAMDA, y redes neuronales para clasificar datos de marcha de voluntarios con enfermedades neurodegenerativas y un grupo de control. Se entrenaron clasificadores de dos clases: Ctrl+PD, Ctrl+PD y Ctrl+HD. El emparejamiento mejoró el ajuste de LAMDA con un 98,3%, el de la red neuronal con un 97,0% y el de Fuzzy C-means con un 90,2%. El uso potencial de estas técnicas de clasificación permitirá la detección temprana de enfermedades neurodegenerativas, incluyendo nuevos dispositivos que permitan el análisis de la marcha fuera del laboratorio.
Water level prediction of pumping station pre-station based on machine learning methods
Authors: Wang Weilin , Sang Guoqing , Zhao Qiang , Lu Longbin
Published: September 2023

Water level prediction is an essential factor for the safe operation of pumping stations. However, due to the complex nonlinear relationship between the water level of the front pool of the pumping station and the influencing factors, the prediction of the water level is still inaccurate and untimely. Backpropagation (BP) neural network, improved particle swarm optimization-BP neural network (PSO-BP), support vector machine regression (SVR), and improved PSO-SVR were used to construct 4-h and 8-h ahead prediction models for pumping station prestation water levels. Mean absolute error, mean squared error (MSE), root mean square error (RMSE), mean absolute percentage error (MAPE), and R correlation coefficient were used as prediction evaluation metrics. This method is applied in the Baliwan Pumping Station, the highest pumping station in the South-to-North Water Diversion Eastern Route Project (SNWDERP). The results showed that the MSE, RMSE, and MAPE of the improved PSO-BP model were smaller than other models, whereas the R correlation coefficient was larger, confirming its high prediction accuracy. All models had higher prediction accuracy 4 h ahead than 8 h ahead. Combining the time-phased water level prediction method and hybrid machine learning can enhance the water level prediction accuracy of a pumping station pre-station.