bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Study of Machine Learning Algorithms for Predictive Healthcare: Applications in Diabetes Management and Breast Cancer Detection
Authors: Mehta Dr Dinesh
Published: February 2025

Machine learning (ML) has revolutionized predictive healthcare by enhancing early detection, diagnosis, and management of chronic diseases. This study presents a comparative analysis of ML algorithms for diabetes management and breast cancer detection. The research evaluates the effectiveness of Random Forest, Logistic Regression, Support Vector Machines (SVM), Decision Trees, and Linear Regression in predicting patient outcomes. The diabetes dataset includes medical and demographic factors such as age, BMI, HbA1c levels, and glucose levels. In contrast, the breast cancer dataset comprises tumor-related attributes like clump thickness, uniformity of cell size, and marginal adhesion. The results indicate that Random Forest consistently achieves the highest accuracy across both use cases, demonstrating its robustness in handling complex medical datasets. For diabetes prediction, Random Forest outperformed other models with an accuracy of 90.78%, while breast cancer detection achieved a classification accuracy of 96.50%. Logistic Regression and SVM also showed promising results but were less effective in handling non-linear relationships and high-dimensional data. While interpretable, decision Trees and Linear Regression required more extensive datasets to achieve comparable accuracy. This research highlights the potential of machine learning (ML) to enhance public health and lower healthcare costs through early diagnosis and personalized treatment. By integrating predictive models into clinical workflows like Electronic Health Records (EHRs), timely interventions and better resource allocation can be achieved, improving patient outcomes.
FEATURES OF THE PHENOLOGICAL STAGES OF ECHINACEA PURPUREA DEVELOPMENT IN THE FOREST-STEPPE OF THE VOLGA REGION
Authors:   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", GUSCHINA V.A. , NIKOLSKAYA E.O. ,   FSI Roslesozashchita – Forest Protection Centre of Penza Oblast, Branch office, KOCHEMAZOVA N.V. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University"
Published: February 2025

The growing interest in medicinal plant raw materials in recent times is related to their use in conventional and folk medicine. Numerous studies have been carried out to investigate the biological and immunological effects of Echinacea purpurea on the human and animal body. Recently, however, it has also been used in urban landscaping. Phenological observations are an indispensable part of the study of plants. They help to reveal the ecological and physiological restructuring of the crop, which is very important in practice. Therefore, the purpose of the study is to investigate the seasonal development of Echinacea and its adaptability in the conditions of the forest-steppe of the Middle Volga region for the landscape design. When growing Echinacea in 2018...2020 on meadow chernozem soil, it was found that the duration of the vegetation period was 145, 155 and 164 days, corresponding to the years of the study. The weather and climatic conditions in the Penza region provide the transition of the phenological rhythms of Echinacea purpurea of the fourth year of life. The most optimal conditions for its development were in 2020, when the hydrothermal coefficient for the vegetation period was 1.17, compared to 0.50 and 0.68 in previous years of research. The development of plants requires the sum of active temperatures from 1214.9 to 1271.0 °С. The change in the rhythm of growth and development processes is also influenced by plant nutrition. However, the acceleration and duration of flowering, which lasted 44...51 days, was influenced to a greater extent by the treatment of plants with Zircon in the leaf rosette stage. Seed ripening takes place at the sum of active temperatures from 2577.7 to 2681.7 °С and the dry inflorescences retain their ornamental value in winter.
MERGERS AND ACQUISITIONS IN THE AGRO-INDUSTRIAL SECTOR AS A FACTOR TO IMPROVE ITS EFFICIENCY IN THE CONTEXT OF ECONOMIC TRANSFORMATION
Authors:   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", NOSOV A.V. , TAGIROVA O.A. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", FEDOTOVA M.YU. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", VINNICHEK L.B. ,   Federal State Budgetary Educational Institution of Higher Education "St. Petersburg State Agrarian University", ZONTIKOVA E.S. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University"
Published: February 2025

The purpose of the study is to develop proposals to improve the efficiency of the country's agricultural sector by activating the processes of mergers and acquisitions (M&A). The object of the study was the mergers and acquisitions market in the agro-industrial sector of the Russian Federation. The proposed directions for solving the problem of reducing the efficiency of the agro-industrial sector and for achieving the goals set by the Strategy for the Development of agro-industrial and fisheries sectors imply a trend towards consolidation and integration of the industry through the growth of mergers and acquisitions. These processes should lead to improving efficiency of concentration and redistribution of industrial, technical, financial, labor and other resources of the subjects of integrated formations, an increase in maneuverability and efficiency in their use, as well as the introduction of innovative developments. Currently, mergers and acquisitions in the agro–industrial sector occupy a small share of about 6% in the total volume. However, there is a huge potential reserve in the field of vertical integration: due to high inflation and rising costs, agricultural holdings will be able to reduce corporate risks by controlling costs along the entire production chain. In modern conditions, the agro-industrial complex of Russia can develop successfully only if balanced relations are ensured between agriculture, processing sector and sale of products, as well as industries producing means of production for it.
EVALUATION OF TURKEY OF HYBRID CONVERTER AND BIG-6 CROSSES BY PRODUCTIVE QUALITIES
Authors:   Federal State Budgetary Educational Institution of Higher Education “Penza State Agrarian University”, SHISHKINA T.V. , TULYAKOV A.A. ,   Federal State Budgetary Educational Institution of Higher Education “Penza State Agrarian University”
Published: February 2025

One of the intensively developing poultry farming industries in recent years is turkey farming. The share of turkey meat is 10% of the total poultry meat production in the world. In Russia, mainly for the production of poultry meat, and, in particular, turkey, Hybrid Converter and Big-6 crosses are used. In this regard, our goal was to compare the productive qualities of poultry by comparing the growth and development of turkeys of Hybrid Converter and Big-6 crosses. The assessment was carried out by studying the growth dynamics of absolute, average daily and relative body weight gains. Along with this, we also calculated the feed conversion and the meat productivity index. As a result, when comparing females and males by live weight, it was found that males surpassed females. The comparative characteristics of Hybrid Converter and Big-6 crosses in terms of live weight, absolute, average daily and relative live weight gains showed that the Hybrid Converter cross surpassed Big-6 in all analyzed indicators. The productive qualities of turkeys show that the absolute increase in body weight in females of the Hybrid Converter cross over the entire period compared with females of the Big-6 cross was higher by 92 g or 0.9%; in males by 895 g or 4.7%. The lowest feed costs per 1 kg of body weight gain were noted in the Hybrid Converter cross and amounted to 2.62 kg in females and 2.86 kg in males. In females, the feed conversion in the Hybrid Converter cross was lower by 0.07 kg or 2.7%; in males by 0.08 kg or 2.8%. Thus, a comparative assessment of the productive qualities of turkeys of two different crosses showed that the Hybrid Converter cross has a higher genetic potential for productivity, as well as high growth rates and its intensity.
IMPROVING THE EFFICIENCY OF THE DIESEL POWER PLANT IN LOW TEMPERATURE CONDITIONS
Authors:   Michurinsk State Agrarian University, RODIONOV YU.V. ,   Tambov State Technical University, BAGLAEV A.A. ,   Air Force Academy named after Prof. N.E. Zhukovsky and Yu.A. Gagarin, SVIRIDOV A.A. ,   Air Force Academy named after Prof. N.E. Zhukovsky and Yu.A. Gagarin, SHAPOVALOV A.A. ,   Air Force Academy named after Prof. N.E. Zhukovsky and Yu.A. Gagarin, KHOKHLOV I.G. ,   Air Force Academy named after Prof. N.E. Zhukovsky and Yu.A. Gagarin, RYBIN G.V. ,   Tambov State Technical University
Published: February 2025

The operation of automotive equipment in conditions of low temperatures is associated with a large number of difficulties and premature failures, which arise, among other things, due to supercooling of diesel fuel. At the same time, despite the obvious problem, there are no effective solutions in mass production in our country, which leads either to an increase in engine start time or to the need to independently manufacture appropriate technical solutions, which is associated with high risks. It is also worth noting that it is necessary to develop heating systems for the entire fuel system, not just the fuel tank, since clogging of filters and fuel lines is the most common cause of failures. The article draws up a schematic diagram and analyzes the factors affecting the combustion process of diesel fuel, describes devices and technical solutions for heating the fuel system of a diesel engine, provides a device and a method for calculating the geometric characteristics of a filler neck for operation in winter conditions. The methodology is described and studies of the operational parameters of the diesel power plant (YAMZ-236NE) installed on the KI-5540 load stand are carried out. According to the results of experimental studies, the effectiveness of the proposed technological solutions has been proven.
SILICON FERTILIZERS AND FORMATION OF CORN YIELDS
Authors:   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", SEMINA S.A. , GAVRYUSHINA I.V. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", PALIYCHUK A.S. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", NIKULINA E.V. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", GORYAINOVA O.A. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University"
Published: February 2025

The article presents the results of research on the formation of corn phytomass yield depending on the type of silicon-containing fertilizer and the period of foliar fertilization. The use of silicon-containing fertilizers, depending on the duration and frequency of treatment, contributed to an increase in photosynthetic potential by 9.6-17.8%. A large total leaf surface during the growing season was formed by binary treatment with Nanokremniy and Microvit-6 Silicon, as well as in the variant using Microvit-6 Silicon in the five-leaf stage. However, as the size of the assimilation apparatus increases, a decrease in photosynthesis productivity is noted. A higher yield level of crude phytomass was obtained in variants with Microvit-6 Silicon: with a single treatment, an additional 7.5-8.0 t/ha of green mass was obtained, and with a double treatment, the increase was 12.4 t/ha or 27.6% of the control. Top dressing with Nanokremniy and Kelic Potassium + Silicon in the 7-8 leaf stage contributed 3.1-4.4 t/ha of green mass to the control, and when treated in the five leaf stage, the increase was 1.3-1.9 t/ha. The binary use of Nanokremniy contributed to an increase in the yield of phytomass by 15.6%, and Potassium + Kelic Silicon by 10.3% to the control.
The Importance of International Trade in Developing Countries
Authors: Hathi Pradeep N.
Published: February 2025

International trade plays a vital role in the economic development of developing countries. It provides these nations with access to larger markets beyond their borders, enabling them to sell their goods and services to a global audience. This exposure not only increases revenue but also encourages local businesses to enhance their production capabilities and innovate. Furthermore, international trade facilitates the transfer of technology and knowledge, which can significantly boost productivity and efficiency in various sectors. Additionally, engaging in international trade helps developing countries diversify their economies, reducing dependence on a limited number of exports. This diversification is vital for economic stability, as it mitigates risks associated with price fluctuations and demand changes in specific markets. Moreover, trade can facilitate job creation, as the augmentation of production and export activities demands an expanded and more diversified workforce. Additionally, it allows access to essential resources, improves competitiveness by setting global standards, and encourages cultural exchange that enhances diplomatic relations. Also, the integration into the global economy through international trade promotes sustainable development, improves living standards, and contributes to poverty alleviation in developing countries.
ANALISIS DAMPAK PEMBANGUNAN BERKELANJUTAN TERHADAP LINGKUNGAN DI KAWASAN INDUSTRI CIKARANG, KABUPATEN BEKASI
Authors: Fadhilla Gheitsa Nur , Fadjarajani Siti , Darmawan Cahya
Published: February 2025

Artikel ini menganalisis dampak pembangunan berkelanjutan terhadap lingkungan di Kawasan Industri Cikarang, Kabupaten Bekasi. Pembangunan berkelanjutan di kawasan ini bertujuan untuk meningkatkan pertumbuhan ekonomi sambil meminimalkan kerusakan lingkungan. Hasil analisis pada menunjukkan bahwa meskipun terdapat upaya untuk menerapkan praktik pembangunan berkelanjutan, dampak negatif seperti pencemaran udara, limbah industri, dan penurunan kualitas tanah masih terjadi. Namun, terdapat juga inisiatif positif dalam pengelolaan sumber daya alam dan konservasi lingkungan yang dapat mendukung keberlanjutan. Penelitian ini menyarankan perlunya penguatan regulasi dan peningkatan kesadaran masyarakat untuk mencapai tujuan pembangunan berkelanjutan yang lebih efektif di Kawasan Industri Cikarang.
Factor of ensuring safety of freight transportation: issues of qualification and training of drivers
Authors:   Malihina O. V. Nujnaya K. G.
Published: February 2025

This article examines the role of the human factor — the "driver" in ensuring transportation safety from the point of view of initial and subsequent training; it examines the foreign approach and experience to the issue of training truck drivers for transportation safety.

Keywords
transportation safety, training driver, safe driving, defensive driving
IMPLEMENTATION OF ENVIRONMENTAL AND ECONOMIC PARAMETERS IN INFORMATION MODELING TECHNOLOGY: INTERNATIONAL AND UKRAINIAN EXPERIENCE
Authors: Skakun V.
Published: February 2025

Abstract. This article examines the integration of environmental and economic parameters in information modeling technology, focusing on building information modeling (BIM), and also examines international and Ukrainian experience. The relevance of this integration is emphasized by the global transition to sustainable development, the need for economic efficiency and the growing regulatory requirements in the construction industry. Internationally, countries such as the United States, the United Kingdom, and Germany have set the standard by successfully implementing these parameters in BIM, resulting in increased project sustainability, reduced environmental impact, and life cycle cost optimization. These practices have demonstrated significant improvements in energy efficiency, waste reduction and cost management, illustrating the tangible benefits of this approach.
In Ukraine, the implementation of BIM with integrated environmental and economic parameters is progressing, which is due to the country's desire to harmonize the standards of the European Union and the goals of sustainable development. Ukrainian projects that have implemented these practices are showing promising results in terms of better resource management, environmental compliance, and improved economic performance. The Ukrainian experience, while still developing, highlights the potential for wider adoption and adaptation of these practices in the national construction industry.
The integration of these parameters into BIM technology is facilitated by the continuous advancement of software and tools, including cloud computing, artificial intelligence and the Internet of Things (IoT). These technologies extend the capabilities of BIM to manage complex data, support real-time decision-making, and improve overall project management. The article emphasizes the importance of this integration to achieve regulatory compliance, promote sustainability, and improve the economic efficiency of construction projects. The implementation of environmental and economic parameters in BIM is important for solving modern challenges in the construction sector. Both international and Ukrainian experience provide valuable information about the advantages and best practices of this integration. As the global focus on sustainability and economic efficiency increases, the adoption of BIM with these integrated parameters will become increasingly critical in ensuring compliance with regulatory standards, fostering innovation and promoting sustainability and economic sustainability. Such a comprehensive approach is necessary for the construction industry to effectively meet current and future requirements.
BASIC FUNCTIONALITIES OF CONSTRUCTION ORGANIZATION AND MANAGEMENT IN THE CONCEPT OF DIGITAL TRANSFORMATION OF ENTERPRISES' OPERATIONAL SYSTEMS
Authors: Druzhynin M. , Malykhinа О. , Herhi M. , Katsiuba I. , Kyryk Ya. , Yuitao Wang
Published: February 2025

Abstract. The article explores modern innovative approaches to updating the operational systems of construction development enterprises in an unstable business environment. It emphasizes the necessity of business process transformation, digital technology integration, and adaptation to dynamic market changes. The construction industry is increasingly facing challenges such as economic instability, inflationary trends, supply chain disruptions, and evolving consumer preferences, which make traditional operational models ineffective. To remain competitive, companies must embrace cutting-edge technologies and implement strategic innovations that enhance efficiency, cost control, and risk management. The study examines key modernization tools, including Building Information Modeling (BIM), which provides a unified digital environment for project management, ensuring greater transparency, improved stakeholder coordination, and enhanced risk prediction. The integration of Big Data analytics and digital dashboards allows for real-time monitoring of key performance indicators (KPIs) and more informed decision-making. Furthermore, the application of Agile and Scrum methodologies in construction project management facilitates flexible planning, accelerates project completion, and improves communication among stakeholders. Additionally, the article highlights the significance of process automation through digital platforms such as Procore and Autodesk Construction Cloud, which streamline workflow management, optimize resource allocation, and minimize financial risks. The implementation of smart construction technologies helps reduce delays, prevent errors, and improve overall project execution. The study presents real-world examples of successful innovation adoption, including landmark projects such as California Pacific Medical Center (USA), Hudson Yards (New York), and Hammarby Sjцstad (Sweden). These case studies demonstrate how digital transformation and automation lead to increased productivity, cost savings, and improved sustainability in construction projects. A systematic approach to managing construction ecosystems is proposed, emphasizing the need for digital technology integration, compliance with environmental standards, and the adoption of flexible collaboration models. The study suggests that utilizing smart platforms for project monitoring and digital analytics further contributes to optimizing operational processes, reducing inefficiencies, and enhancing longterm sustainability. By adopting innovative strategies and leveraging advanced digital tools, construction enterprises can strengthen their competitive position and ensure resilience in a rapidly changing industry.
PHYSICO-CHEMICAL CHARACTERISTICS OF THE HYDRATION PROCESSES OF MODIFIED COLORED PORTLAND CEMENT
Authors: Pushkarova K. , Tereshchenko L.
Published: February 2025

Abstract. The article presents the results of research on the physico-chemical features of the hydration processes of modified Portland cement and determines the influence of nanocarbonate additives on the processes of artificial stone structure formation. Research was conducted on cement systems based on plasticized white Portland cement with the addition of red pigment and modified with a nanocarbonate additive in the form of a dispersion. It was established that the structure of cement stone without the addition of pigment is more homogeneous, and when pigment is added, microcracks are formed due to internal stresses arising in the contact zone. The formation of cracks can be explained by the features of the pore structure formed when the pigment is added. Since the addition of pigment for a dough of normal thickness requires an increase in the water-cement ratio, more pores are formed in such a cement stone that cannot be immediately filled with cement hydration products. When a nanocarbonate additive is introduced into the pigmented cement system, we can observe the overgrowth of cracks formed as a result of the addition of pigment, the formation of a fairly homogeneous structure, and the overgrowth of pores. Regulation of the strength and operational characteristics of colored cements is relevant, since the introduction of pigment leads to a decrease in the strength of artificial stone. Solving this problem by means of nanomodification reveals a new possibility of stabilizing the strength and operational characteristics of not only white but also colored cements. The introduction of a nanocarbonate additive in the form of a dispersion to the pigmented cement system contributes to the formation of a more perfect dense and uniform structure of cement stone. As a result, it is possible to obtain a cement system resistant to the appearance of microcracks, with less porosity, including open porosity, which is important for colored cements in the composition of plaster mixtures
FORMATION OF A CREATIVE-INNOVATIVE ECOSYSTEM FOR SUSTAINABLE DEVELOPMENT IN THE CONSTRUCTION INDUSTRY AMIDST TURBULENCE AND UNCERTAINTY
Authors: Humenna O.
Published: February 2025

Abstract. The modern construction industry operates under conditions of increased turbulence and uncertainty caused by global crises, climate change, geopolitical conflicts, and economic instability. At the same time, the urgent need for a transition to sustainable development is driving the search for new management models and the organization of innovative processes.
This article explores the concept of a creative-innovative ecosystem for the sustainable development of the construction industry as an integrated model that brings together stakeholders from science, business, government, and civil society. It examines key approaches to defining the concept of an "innovation ecosystem" and its evolution, from J. Schumpeter’s ideas and the concept of national innovation systems to modern models of open innovation and collaborative platforms. The article substantiates the key characteristics of the creative-innovative ecosystem for sustainable onstruction development: sustainability, innovativeness, creativity, collaboration, and the circular economy. A structural model of this ecosystem is proposed, including a research segment, technological infrastructure, environmental component, economic and financial mechanisms, regulatory and legal framework, and social aspects. The main challenges of implementing this model are identified, including insufficient funding, low levels of environmental awareness, and resistance from the traditional construction sector to change. Particular attention is given to turbulence and uncertainty as key factors defining the industry's development specifics. Their impact on the technological, economic, and managerial aspects of the construction sector’s functioning is highlighted. Strategic risk management approaches are proposed, based on adaptability, digitalization, and the use of open innovation. The practical significance of the study lies in the development of recommendations for creating an effective interaction mechanism between ecosystem participants, fostering innovative approaches in construction. The conclusions emphasize the necessity of a comprehensive approach to forming a creative-innovative ecosystem for sustainable development, ensuring the resilience of the construction industry and its adaptation to modern challenges.
FORMATION OF A METHODOLOGICAL BASIS OF RESEARCH FROM THE POSITION OF MODERNIZATION OF THE INFORMATION SPACE OF THE ENVIRONMENT AND STAKEHOLDERS OF A CONSTRUCTION PROJECT
Authors: Malykhin M.O.
Published: February 2025

Abstract. The relevance of forming a methodological basis for the study of construction projects from the position of modernization of the information space of the environment and stakeholders is due to the need to implement modern information technologies and effectively manage complex processes in construction. In the light of the digital transformation of the industry, intelligent information systems play an increasingly important role, influencing the interaction of all project participants and ensuring its successful implementation in a rapidly changing environment. The central task of the study is to develop a methodological framework for the implementation of modern technologies for managing information flows, which ensure coordinated interaction between stakeholders of a construction project. In modern conditions, the information space of the project becomes a key element that unites the interests of investors, contractors, government agencies, end users and other participants in the process. The study focuses on the formation of clear mechanisms for information exchange and methods for managing information resources, which will allow optimizing decision-making processes and reducing risks associated with the implementation of construction projects. Particular attention is paid to the issues of informatization of the processes of planning, design, construction and operation of facilities. The study considers approaches to the use of building information models (BIM technologies), which ensure the integration of all stages of the project life cycle and allow improving the quality of resource management. Innovative information systems contribute to more effective control of work performance, cost optimization and ensure transparency of the process for all stakeholders. The paper also examines the issues of professional development of specialists working in the construction sector, as the modernization of the information space requires appropriate competencies and skills. For this purpose, training and professional development methods are proposed, focused on mastering modern information technologies, managing large amounts of data and effective communication within projects.
Transactions with Special Approval Procedure Stipulated by the Charter of a Business Entity: Enforcement Issues
Authors:   Kutafin Moscow State Law University (MSAL), Gadzhiev Aslan E.
Published: February 2025

The article analyses the transactions with special approval procedure stipulated by the charter of a business entity in corporate law of Russia. The subject of proof in disputes challenging transactions conducted in violation of the sole executive body’s authority limitations, established by the corporation’s charter, is examined. It has been established that the failure to prove the counterparty’s awareness of the restrictions set forth in the company’s charter is the main reason for the dismissal of claims. Factors that make it difficult to establish awareness and typical mistakes made by courts in resolving such cases have been identified. Against this background, there is a tendency to reduce the number of claims for invalidation of these transactions. To resolve law enforcement problems, the necessity of institutionalisation of the principle of public limitation of powers of corporate management bodies, providing for the opposition of statutory restrictions to third parties when they are entered into the Unified State Register of Legal Entities (EGRUL), has been substantiated. The implementation of this principle and the proposed measures to improve the legislation will narrow the scope of the principles of public trustworthiness of the register and abstraction, which limit the potential for statutory extraordinariness. The proposed reform will enhance the protection and safeguarding of corporations, ensure consideration of their individual interests, increase the stability of civil turnover, and improve the attractiveness of the Russian jurisdiction.
The Westwalk Case and Topical Issues of Cross-Border Insolvency in Russia
Authors: Kvashnin Pavel R.
Published: February 2025

The article analyses the relevance and challenges of cross-border insolvency in Russia. The author emphasises the impact of foreign approaches to the regulation of cross-border insolvency on Russian case law. The research focuses on identifying general trends and issues, given the limited number of examples from Russian case law. The author examines key aspects such as the concept of the centre of main interests (COMI) and the interaction between main and secondary proceedings. The author compares some conclusions made by the Supreme Court of the Russian Federation in the Westwalk case with international approaches. This case serves as an important reference point for illustrating existing problems and forecasting future legal practice in cross-border insolvency cases within the Russian legal system. Contemporary Russian law is characterised by the absence of legislative regulation concerning cross-border insolvency. Nevertheless, Russian courts hear insolvency cases involving foreign individuals and, more recently, legal entities. In making decisions on these cases, they refer to the UNCITRAL Model Law and Regulation (EU) No. 2015/848 of May 20, 2015. In conclusion, the author suggests to implement the UNCITRAL Model Law on Cross-Border Insolvency or conclude an international treaty on cross-border insolvency with CIS and EAEU States, with which the Russian Federation has established close economic ties.
Forwarding Court Judgments and Arbitral Awards by Way of Legal Assistance for the Purpose of Their Enforcement in a Foreign State
Authors:   Private Law Research Centre, Kostin Alexander A. ,   MGIMO
Published: February 2025

The article addresses the provisions of international treaties, according to which the recoverer should send the request for enforcement of a court judgment abroad to the court that rendered the judgment in the first instance, and not to the court of the state of the debtor’s location (i.e. a foreign court). The literal interpretation of these norms shows that the recoverer has no possibility to send the request to a foreign court directly, bypassing the forwarding of the judgment by way of legal assistance (except in cases where the recoverer has residence or location in the state of enforcement of the judgment). In the author’s opinion, such an interpretation contradicts to the purpose of the relevant treaties — to ensure access to the courts of the contracting countries. Therefore, if the national legislation establishes a more favourable legal regime, it should be applied.
Methodology of Collecting the Evidence in Criminal Procedure: Static Effect in Dynamic Perspective
Authors:   Lomonosov Moscow State University, Golovko Leonid V.
Published: February 2025

Two crucial methodological foundations of using the evidence remain underestimated in criminal procedure theory. These are, firstly, static effect and, secondly, dynamic perspective of proving in criminal cases. However, without them we cannot adequately address problems of electronic evidence and electronic criminal case that are actively discussed in the doctrine of criminal procedure and cause numerous disputes. Correct understanding of the methodology of criminal procedural proof makes these problems appear far-fetched.
On the Issue of Sanction for the Evasion of the Party to the Case from Presenting the Evidence Requested by the Court
Authors:   Saint Petersburg State University, Zatonova Daria Yu.
Published: February 2025

The article substantiates the need to apply a procedural sanction in the form of the application of the presumption of recognition to the party of the case that evades the provision of evidence requested by the court, i.e., the application by analogy of Part 3 of Article 79 of the Civil Procedure Code of the Russian Federation to cases of non-presentation of written and material evidence. A sanction in the form of a presumption of recognition can only be applied if the court is highly likely convinced that the party has the required evidence, but refuses to provide it without good reason. The application of property sanctions to persons involved in the case who evade the presentation of evidence requested by the court is ineffective.
The Impact of Health Policy on Community-Based Palliative Care Services: A Mixed-Methods Evaluation in Bandung, Indonesia
Authors: Dea Albertina  , Istiqomah Putri  , Nazeera Hamid  , Cindy Susanti
Published: February 2025

Palliative care is a crucial component of comprehensive healthcare, yet access to community-based palliative care services remains limited in many low- and middle-income countries, including Indonesia. This study aimed to evaluate the impact of existing health policies on community-based palliative care in Bandung, Indonesia. A mixed-methods approach was employed, combining quantitative and qualitative data collection and analysis. Quantitative data included a retrospective analysis of patient records (n=350) from three community-based palliative care providers in Bandung from 2018-2023, assessing referral patterns, service utilization, and patient demographics. Qualitative data were gathered through semi-structured interviews with policymakers (n=10), healthcare providers (n=15), and patients/caregivers (n=20) to explore their perspectives on policy implementation and its impact. Data were analyzed using descriptive statistics, thematic analysis, and a framework approach guided by the WHO Health Systems Framework. The study found that while national health policies acknowledge the importance of palliative care, significant gaps exist in implementation at the local level. The number of patients accessing community-based palliative care increased modestly from 45 in 2018 to 78 in 2023, but this represents a small fraction of the estimated need. Key policy-related barriers identified included: limited funding allocated specifically for community-based palliative care , inadequate training and workforce capacity in palliative care, lack of standardized referral pathways from hospitals to community-based services and limited public awareness of palliative care. In conclusion, health policies in Indonesia have not yet translated into widespread access to quality community-based palliative care in Bandung. Strengthened policy implementation, increased funding, workforce development, improved referral systems, and enhanced public awareness are crucial to address this gap and improve the quality of life for patients with life-limiting illnesses and their families.
Neurostimulation devices to treat Alzheimer’s disease
Authors: Perez Felipe P. , Walker Brett , Morisaki Jorge , Kanakri Haitham , Rizkalla Maher
Published: February 2025

The use of neurostimulation devices for the treatment of Alzheimer’s disease (AD) is a growing field. In this review, we examine the mechanism of action and therapeutic indications of these neurostimulation devices in the AD process. Rapid advancements in neurostimulation technologies are providing non-pharmacological relief to patients affected by AD pathology. Neurostimulation therapies include electrical stimulation that targets the circuitry-level connection in important brain areas such as the hippocampus to induce therapeutic neuromodulation of dysfunctional neural circuitry and electromagnetic field (EMF) stimulation that targets anti-amyloid molecular pathways to promote the degradation of beta-amyloid (Aβ). These devices target specific or diffuse cortical and subcortical brain areas to modulate neuronal activity at the electrophysiological or molecular pathway level, providing therapeutic effects for AD. This review attempts to determine the most effective and safe neurostimulation device for AD and provides an overview of potential and current clinical indications. Several EMF devices have shown a beneficial or harmful effect in cell cultures and animal models but not in AD human studies. These contradictory results may be related to the stimulation parameters of these devices, such as frequency, penetration depth, power deposition measured by specific absorption rate, time of exposure, type of cell, and tissue dielectric properties. Based on this, determining the optimal stimulation parameters for EMF devices in AD and understanding their mechanism of action is essential to promote their clinical application, our review suggests that repeated EMF stimulation (REMFS) is the most appropriate device for human AD treatments. Before its clinical application, it is necessary to consider the complicated and interconnected genetic and epigenetic effects of REMFS-biological system interaction. This will move forward the urgently needed therapy of EMF in human AD.
The role of neuroimaging in Alzheimer’s disease: implications for the diagnosis, monitoring disease progression, and treatment
Authors: Mulumba Julius , Duan Rui , Luo Bo , Wu Jiang , Sulaiman Muhammad , Wang Feng , Yang Yong
Published: February 2025

Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. It presents a significant challenge in terms of accurate diagnosis, disease progression monitoring, and the development of effective treatments. This article addresses the role of neuroimaging as an advancing tool for diagnosis, monitoring progression, and treatment of AD. A comprehensive review of existing literature on the use of neuroimaging in AD was conducted using various databases. The different imaging techniques, such as magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), and positron emission tomography (PET), were examined in terms of their ability to detect amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs), the hallmark pathological features of AD. Neuroimaging enables the visualization of Alzheimer-related biomarkers, such as Aβ plaques, tau protein tangles, neuro-inflammation, and synaptic dysfunction, providing valuable insights into disease pathophysiology and progression. These imaging techniques assist in the early detection of AD, distinguishing it from other conditions and evaluating the effectiveness of treatments. This has the potential to significantly transform the way AD is managed clinically. By providing insights into the molecular changes that occur in the brain during the course of the disease, neuroimaging can facilitate early diagnosis, monitor disease progression, and inform treatment decisions. Furthermore, neuroimaging holds great potential for accelerating drug development by allowing researchers to assess the efficacy of novel therapies in real time. Overall, the integration of neuroimaging into the clinical management of AD has the potential to revolutionize the way we approach diagnosis, treatment, and research in AD.
Genomic alterations in the WNT/β-catenin pathway and resistance of colorectal cancer cells to pathway-targeting therapies
Authors: Voutsadakis Ioannis A.
Published: February 2025

Aim: Colorectal cancer is the most prevalent gastrointestinal malignancy with limited therapeutic options in the metastatic setting. The WNT/β-catenin/adenomatous polyposis coli (APC) pathway is commonly deregulated in the disease and presents a rational target for therapeutic exploitation.
Methods: The publicly available genomic data from the colorectal cancer cohort of the Cancer Genome Atlas (TCGA) were used to define groups of colorectal cancers with alterations in APC or other key genes of the WNT/β-catenin/APC pathway and to identify genomic characteristics of interest in each group. In vitro sensitivity data for drugs targeting the pathway were compiled from the Genomics of Drug Sensitivity in Cancer (GDSC) project.
Results: Three-fourths of colorectal cancers possessed APC alterations and about one in four of these cases possessed also concomitant alterations in other genes of the WNT/β-catenin/APC pathway, including RNF43, CTNNB1, and TCF7L2. Colorectal cancers with alterations in one or more of the three genes of the WNT/β-catenin pathway, RNF43, CTNNB1, and TCF7L2, in the absence of APC alterations, were frequently microsatellite instability (MSI) high and had high tumor mutation burden (TMB). Cancers with these same alterations in the three genes with or without APC alterations presented a high frequency of mutations in receptor tyrosine kinases, PI3K/AKT pathway genes, and DNA damage response genes. Cell lines without mutations in WNT/β-catenin/APC pathway components displayed numerically greater sensitivity to inhibitors of the pathway in vitro.
Conclusions: Groups of colorectal cancers differing in WNT/β-catenin/APC pathway alterations present diverse genomic landscapes that could have therapeutic implications for the rational development of inhibitors of the pathway.
Some Classes of Matrix Transformations between the Subsets of Maddox Spaces Defined by Speed
Authors: Aasma Ants , Natarajan Pinnangudi N.
Published: February 2025

Let X, Y be two sets of sequences with real or complex entries, and (X, Y) the set of all matrices with real or complex entries to map X into Y. Let λ and μ be speeds of convergence, i.e., monotonically increasing strictly positive sequences. In this paper, some classes of matrix transforms, where X is the subset of certain Maddox space defined by λ, and Y is the subset of another Maddox space defined by μ, have been characterized. The application possibilities of the main results are demonstrated with two examples.
Square mean (ω, c)-periodic Limit Stochastic Processes and Some Basic Results
Authors: Dalla Zineb , Khalladi Mohammed Taha , Gasmi Laid
Published: February 2025

This paper aims to introduce new classes of square mean (ω, c)-periodic limit-type stochastic processes. The main structural characterizations and some qualitative properties of the introduced classes are established, as well as their invariance under the actions of convolution product and the composition principle.
Platelet activation relieves liver portal hypertension via the lymphatic system though the classical vascular endothelial growth factor receptor 3 signaling pathway
Authors: Chen Min , Zhao Jin-Bo , Wu Guang-Bo , Wu Zheng-Hao , Luo Gu-Qing , Zhao Zhi-Feng , Zhang Chi-Hao , Lin Jia-Yun , Li Hong-Jie , Qi Xiao-Liang , Huo Hai-Zhong , Tuersun Abudukadier , Fan Qiang , Zheng Lei , Luo Meng
Published: February 2025

BACKGROUND

Liver cirrhosis and portal hypertension (PHT) can lead to lymphatic abnormalities and coagulation dysfunction. Because lymphangiogenesis may relieve liver cirrhosis and PHT, the present study investigated the gene expression alterations in the lymphatic system and the effectiveness of platelet-mediated lymphangiogenesis in improving liver cirrhosis and PHT.

AIM

To investigate the role of lymphangiogenesis in preclinical PHT models.

METHODS

Immunohistochemistry and transcriptome sequencing of bile duct ligation (BDL) and control lymphatic samples were conducted to reveal the indicated signaling pathways. Functional enrichment analyses were performed on the differentially expressed genes and hub genes. Adenoviral infection of vascular endothelial growth factor C (VEGF-C), platelet-rich plasma (PRP), and VEGF3 receptor (VEGFR) inhibitor MAZ-51 was used as an intervention for the lymphatic system in PHT models. Histology, hemodynamic tests and western blot analyses were performed to demonstrate the effects of lymphatic intervention in PHT patients.

RESULTS

Lymphangiogenesis was increased in the BDL rat model. Transcriptome sequencing analysis of the extrahepatic lymphatic system revealed its close association with platelet adherence, aggregation, and activation. The role of PHT in the rat model was investigated by activating (PRP) and inhibiting (MAZ-51) the lymphatic system. PRP promoted lymphangiogenesis, which increased lymphatic drainage, alleviated portal pressure, reduced liver fibrosis, inhibited inflammation, inhibited angiogenesis, and suppressed mesenteric artery remodeling. MAZ-51 reversed the above improvements.

CONCLUSION

Via VEGF-C/VEGFR-3, platelets impede fibrosis, angiogenesis, and mesenteric artery remodeling, ultimately alleviating PHT. Thus, platelet intervention is a therapeutic approach for cirrhosis and PHT.
Overcoming antibiotic-resistant Helicobacter pylori infection: Current challenges and emerging approaches
Authors: Rocha Gabriel Reis , Lemos Fabian Fellipe Bueno , Silva Luis Guilherme de Oliveira , Luz Marcel Silva , Correa Santos Gabriel Lima , Rocha Pinheiro Samuel Luca , Calmon Mariana Santos , de Melo Fabrício Freire
Published: February 2025

Recent studies have shown a noticeable increase in global Helicobacter pylori (H. pylori ) resistance , with clarithromycin resistance surpassing 15% in various areas. However, inadequate epidemiological monitoring, especially in developing countries, and the absence of uniform testing methods lead to discrepancies between regions and a possible underestimation of resistance levels. The complexity of treating H. pylori is driven by its highly dynamic genome, which is prone to frequent mutations contributing to phenotypical resistance. The usual course of action in empirical treatment involves using a combination of various drugs simultaneously, leading to significant resistance selection pressure and potential side effects. The emergence of H. pylori strains resistant to multiple drugs is closely tied to failures in first-line treatment, highlighting the need to prevent further resistance by using optimal initial empirical therapy or regimens guided by antibiotic susceptibility testing, requiring a collection of mixed samples and multiple isolates for accurate assessment. The emergence of new treatments like potassium-competitive acid blockers offers a hopeful approach to decrease antimicrobial usage while still ensuring effectiveness in comparison to traditional therapies with proton pump inhibitors. Additionally, the use of probiotics is under investigation to identify specific strains and formulations that may mitigate therapy-associated adverse effects.