bluuebunny/crossref_metadata_2025 huggingface dataset:
Hysteretic Thermal Spin-Crossover and Symmetry Breaking in Heteroleptic Fe(II) Complexes Using Alkyl Chain Substituted 2,2’-Dipyridylamine Ligands
Authors: Geoghegan Blaise , Phonsri Wasinee , Horton Peter , Orton James , Coles Simon , Murray Keith , Cragg Peter , Dymond Marcus , Gass Ian
Published: August 2019

The alkyl chain carrying ligands N,N-di(pyridin-2-yl)butanamide (LC4) and N,N-di(pyridin-2-yl)decanamide (LC10) were combined with NCS- co-ligands to form the neutral heteroleptic Fe(II) complexes trans-[FeII(LC4)2(NCS)2] (1C4) and trans [FeII(LC10)2(NCS)2] (1C10). Variable temperature crystallographic studies revealed that 1C4 is in the orthorhombic space group Pna21 between 85-200 K whereas 1C10 is in the monoclinic space group P21/c between 85-105 K before undergoing a crystallographic phase transition to the triclinic space group P1􀴤 by 140 K. The average Fe-N bond lengths suggest that at 85 K 1C4 contains LS Fe(II) centres; However, the ca. 0.18 Å increase in the average Fe-N bond lengths between 85 and 120 K suggests a spin-transition occurs within this temperature interval and the HS state is predominant beyond this. 1C10 contains LS Fe(II) centres between 85 and 105 K. Upon warming from 105 to 140 K the average Fe-N bond lengths increase by ca. 0.19 Å, which suggests that a spin-transition to the HS accompanies the P21/c to P1􀴤 crystallographic phase transition. Solid-state magnetic susceptibility measurements showed that 1C4 undergoes semi-abrupt spin-crossover with T1/2 = 127.5 K and a thermal hysteresis of ca. 13 K whereas, 1C10 undergoes an abrupt spin-crossover with T1/2 = 119.0 K, and is also accompanied by thermal hysteresis of ca. 4 K. The crystallographic and magnetic data show that the length of the complex’s alkyl chain substituents can have a large impact on the structure of the crystal lattice as well as a subtle effect on the T1/2 value for thermal spin-crossover.
Emissive Single-Crystalline Boroxine-Linked Colloidal Covalent Organic Frameworks
Authors: Evans Austin , Castano Ioannina , Brumberg Alexandra , Parent Lucas R. , Corcos Amanda , Li Rebecca , Flanders Nathan C. , Gosztola David J. , Gianneschi Nathan , Schaller Richard , Dichtel William
Published: August 2019

The synthesis of periodic two-dimensional (2D) polymers and characterization of their optoelectronic behaviors are challenges at the forefront of polymer chemistry and materials science. Recently, we showed that layered 2D polymers known as 2D covalent organic frameworks (COFs) can be synthesized as single crystals by preparing COF particles as colloidal suspensions. Here we expand this approach from the condensation of boronic acids and catechols to the dehydrative trimerization of polyboronic acids. The resulting boroxine-linked colloids are the next class of 2D COFs to be obtained as single‑crystalline particles, as demonstrated here for four 2D COFs and one 3D COF. Colloidal stabilization enables detailed structural analysis by synchrotron X-ray diffraction and high-resolution transmission electron microscopy. Solution fluorescence spectroscopy revealed that the COF crystallites are highly emissive compared to their respective monomer solutions. Excitation‑emission matrix fluorescence spectroscopy indicated that the origin of this enhanced emission can be attributed to through-space communication of chromophores between COF sheets. These observations will motivate the development of colloidal COF systems as a platform to organize functional aromatic systems into precise and predictable assemblies with emergent properties.
A Phage-Assisted Continuous Selection Approach for Deep Mutational Scanning of Protein-Protein Interactions
Authors: Zinkus-Boltz Julia , Devalk Craig , Dickinson Bryan
Published: August 2019

Protein-protein interactions (PPIs) are critical for organizing molecules in a cell and mediating signaling pathways. Dysregulation of PPIs are often key drivers of disease. To better understand the biophysical basis of such disease processes – and to potentially target them - it is critical to understand the molecular determinants of PPIs. Deep mutational scanning (DMS) facilitates the acquisition of large amounts of biochemical data by coupling selection with high throughput sequencing (HTS). The challenging and labor-intensive design and optimization of a relevant selection platform for DMS, however, limits the use of powerful directed evolution and selection approaches. To address this limitation, we designed a versatile new phage assisted continuous selection (PACS) system using our proximity-dependent split RNA polymerase (RNAP) biosensors with the aim of greatly simplifying and streamlining the design of a new selection platform for PPIs. After characterization and validation using the model KRAS/RAF PPI, we generated a library of RAF variants and subjected them to PACS and DMS. Our HTS data revealed that amino acid (aa) positions 66, 84, and 89 on RAF, key residues in the KRAS/RAF PPI, are intolerant to mutations. We also identified a subset of residues with broad aa substitution tolerance, aa positions 52, 55, 76, and 79. Due to the plug and play nature of RNAP biosensors, this method can easily be extended to other PPIs. More broadly, this, and other methods under development, supports the application of evolutionary and high-throughput approaches to bear on biochemical problems, moving towards a more comprehensive understanding of sequence-function relationships in proteins.
KAP1 is an antiparallel dimer with a functional asymmetry
Authors: Fonti Giulia , Marcaida Maria J , Bryan Louise C , Träger Sylvain , Kalantzi Alexandra S , Helleboid Pierre-Yves JL , Demurtas Davide , Tully Mark D , Grudinin Sergei , Trono Didier , Fierz Beat , Dal Peraro Matteo
Published: August 2019

KAP1 (KRAB domain–associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for macromolecular interactions and as an E3 small ubiquitin modifier ligase. This work sheds light on the overall organization of the full-length protein combining solution scattering data, integrative modeling, and single-molecule experiments. We show that KAP1 is an elongated antiparallel dimer with an asymmetry at the C-terminal domains. This conformation is consistent with the finding that the Really Interesting New Gene (RING) domain contributes to KAP1 auto-SUMOylation. Importantly, this intrinsic asymmetry has key functional implications for the KAP1 network of interactions, as the heterochromatin protein 1 (HP1) occupies only one of the two putative HP1 binding sites on the KAP1 dimer, resulting in an unexpected stoichiometry, even in the context of chromatin fibers.
Análise da variação da pressão arterial e ansiedade odontológica em cirurgias orais: estudo de caso-controle
Authors: Barreto Jaqueline Oliveira , Freire Julliana Cariry Palhano , Brasil Arthur Willian De Lima , Rocha Julierme Ferreira , Ribeiro Eduardo Dias
Published: August 2019

O objetivo da pesquisa foi investigar fatores de risco à hipertensão de jaleco branco entre pacientes adultos submetidos a cirurgia oral, particularmente a ansiedade odontológica. Trata-se de um estudo de caso-controle pareado aninhado em estudo transversal realizado na Universidade Federal de Campina Grande e Faculdades Integradas de Patos, Paraíba, Brasil. Os pacientes tiveram suas pressões aferidas e classificadas de acordo com as V Diretrizes Brasileiras de Hipertensão Arterial (2007) e em seguida foram divididos em dois grupos: hipertensos (casos) e normotensos (controles). Os voluntários dos casos (n = 34) e dos controles (n = 136) foram emparelhados (1: 4) por gênero, faixa etária e escolaridade. Os mesmos responderam uma Escala de Ansiedade de Corah. A hipertensão de jaleco branco foi a variável dependente e a ansiedade odontológica foi a variável independente de interesse. A frequência de visitas ao dentista foi analisada como variável confusa. A análise descritiva, a regressão logística condicional bivariada e multivariada foram utilizadas como testes estatísticos com um nível de significância de 5%. Verificou-se que os pacientes ansiosos foram 11.052 vezes mais propensos à elevação da pressão arterial do que aqueles que não relataram ansiedade (IC 95%: 1.778 – 8.818). Os pacientes que nunca visitaram o dentista ou que o fizeram havia mais de dois anos tiveram 2,971 vezes mais chance de ter elevação da pressão arterial (IC 95%: 1,36 – 4,75). Conclui-se que ansiedade odontológica influencia a elevação da pressão arterial durante as cirurgias orais menores.
Mordida aberta anterior: origem e tratamento
Authors: Silva Beatriz Cardoso da , Santos Dênis Clay Lopes dos , Flaiban Everton , Negrete Daniel , Santos Raquel Lopes dos
Published: August 2019

A mordida aberta anterior é uma maloclusão caracterizada por um trespasse vertical negativo entre os dentes anteriores, quando os dentes posteriores estão em oclusão. Ela pode ser desenvolvida através de diversos fatores etiológicos, tais como os hábitos bucais deletérios (sucção de polegar ou chupeta), anquilose dentária, respiração bucal, amígdalas hipertróficas, interposição lingual e anormalidades no processo de erupção. Esses fatores interferem diretamente no crescimento e desenvolvimento normais das estruturas faciais. É uma das maloclusões de maior comprometimento estético-funcional, além das alterações dentárias e esqueléticas, e seu tratamento é constituído de diferentes abordagens, pois depende de sua classificação e severidade. O objetivo deste trabalho é destacar a importância do diagnóstico e tratamento da mordida aberta anterior, bem como mostrar o que pode causá-la, interferindo no correto funcionamento do sistema estomatognático e bem-estar do paciente.
PATRIOTIC EDUCATION OF STUDENTS IN TEACHING PSYCHOLOGICAL AND PEDAGOGICAL DISCIPLINE (ON EXAMPLE OF CRITICAL THINKING TECHNOLOGY)
Authors: Budak Valeriy , Oleksiuk Oksana
Published: August 2019

The article deals with the problem of formation of university students during the teaching of the psychological and pedagogical disciplines not only the qualities of the patriot of their country, but also the formation of a person who must meet the requirements for the personality of the patriot leader. Examples of «Leader – Thought Thinking», «Synkveyn», «Press» methods during the teaching of psychological and pedagogical disciplines are given. The analysis of the students’ tasks implementation of the «Press» method is conducted in accordance with the determined components of the process of patriotic education: cognitive, motivational-value, activity-behavioural, personally-estimated and socially-valued. The following analysis of the essential characteristic of student answers is outlined as a challenge for further scientific developments.
Regeneration ability of different cultivars of the highbush blueberry (Vaccinium corymbosum L.) propagated by green stem cuttings
Authors: Pavlovskiy N. B.
Published: August 2019

An assessment of the regenerative capacity was made for 20 highbush blueberry cultivars and 3 half-highbush blueberry cultivars introduced in Belarus, based on 9-year research results. Has been established that the regeneration ability of the green cuttings of blueberry is genetically determined with varying degrees of severity in one or another cultivar. The results obtained allowed to classify blueberry cultivars according to their root-forming ability into three groups: easily rooted ((‘Elizabeth’, ‘Hardyblue’, ‘Northland’), medium rooted ((‘Blueray’, ‘Coville’, ‘Croatan’, ‘Darrow’, ‘Denise Blue’, ‘Herbert’, ‘Jersey’, ‘Northcountry’, ‘Reka’, ‘Rubel’) and difficult to resist (‘Bluecrop’, ‘Bluetta’, ‘Bluerose’, ‘Carolinablue’, ‘Duke’, ‘Earliblue’, ‘Nelson’, ‘Northblue’, ‘Patriot’, ‘Weymouth’). It is reliably shown that one hundred varieties of this crop, possessing a higher rootforming ability, produce plants with large biometric parameters of the above-ground sphere. The blue cuttings of highbush and half-highbush blueberries have a satisfactory regenerative capacity, which makes it possible to use this method of vegetative propagation for replication and to obtain planting material of this culture in Belarus.
Hybride metall-organic nanoflowers and their applications in biotechnology
Authors: Abashkin V. M. , Halets-Bu I. V. , Dzmitruk V. G. , Bryszewska M. , Shcharbin D. G. , Odabaşı M. , Acet Ö. , Önal B. , Özdemir N.
Published: August 2019

Among the variety of modern nanomaterials a special class – nanoflowers can be distinguished. These new nanostructures have induced the interest of scientists due to the topographic features of nanolayers, the special location of which allows a higher surface-to-volume ratio compared to classical spherical nanoparticles. Such topographic structure significantly increases the efficiency of surface reactions for nanoflowers. The main purpose of this type of nanomaterials is their use as enzyme stabilizers. Enzymes are biosystems with high activity and substrate specificity, but their use is limited by certain disadvantages, such as high sensitivity to the environment, low reproducibility of experimental results and requirements for complex purification of the components. To facilitate the functioning of enzymes in various conditions, organicinorganic hybrid nanomaterials have been developed, the name of which indicates that all components of inorganic nanoparticles are associated with organic materials. These nanoparticles have numerous promising applications in catalysis, as biosensors, and for drug delivery. Organic-inorganic hybrid nanoflowers have led to the development of a new branch of chemistry – the chemistry of hybrid nanomaterials, whose research is currently undergoing rapid development. Thus, the study of organic-inorganic hybrid nanocrystals can lead to new creative solutions in the field of chemistry of enzyme systems and the rapid development of bionanomaterials and new branches of biotechnology.
From context to context
Authors: Govzich I. N.
Published: August 2019

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Kompetensi Dosen, Motivasi Belajar Mahasiswa dan Dampaknya terhadap Prestasi Mahasiswa dalam Pembelajaran Pengantar Ekonomi (studi pada mahasiswa program studi Manajemen Informatika AMIK Bina Sriwijaya Palembang)
Authors: Alam Yuli
Published: August 2019

ABSTRAKTujuan penelitian – Penelitian ini bertujuan untuk untuk melihat apakah ada pengaruh yang signifikan antara kompetensi dosen dari sudut pandang mahasiswa dan motivasi belajar terhadap prestasi belajar mahasiswa pada mata kuliah Pengantar Ekonomi program studi Manajemen Informatika AMIK Bina Sriwijaya Palembang. Desain/Metodologi/Pendekatan– Data penelitian ini dikumpulkan menggunakan kuesioner, kemudian dianalisis menggunakan Regresi Linier berganda dengan bantuan aplikasi komputer SPSS Temuan– Hasil penelitian menunjukkan bahwa variabel motivasi belajar mahasiswa secara parsial berpengaruh positif dan signifikan terhadap prestasi belajar mahasiswa hal ini dapat dibuktikan dengan nilai t hitung sebesar 3.290 dengan tingkat signifikan sebesar 0.002. Variable Kompetensi dosen juga secara parsial menunjukkan pengaruh yang positif dan signifikan terhadap prestasi belajar mahasiswa dengan nilai t hitung sebesar 4,310 dengan Sig.t = 0,000). Motivasi belajar mahasiswa, Kompetensi dosen menurut sudut pandang mahasiswa secara simultan berpengaruh positif dan signifikan terhadap prestasi belajar mahasiswa. Hal ini dapat dilihat dari nilai F hitung sebesar 14063 dengan tingkat signifikan sebesar 0.000. Keterbatasan penelitian– Penelitian ini hanya terbatas pada variabel kompetensi dosen dari sudut pandang mahasiswa, sehingga dapat dikembangkan dengan variable kompetensi dosen sesuai dengan Undang-undang No 14 tahun 2005 tentang guru dan dosen serta variable motivasi belajar mahasiswa sehingga dapat dikembangkan dengan menambah variable internal lain seperti gaya belajar, lingkungan belajar, fasilitas belajar dan variable lainnya. Originality/value– Penelitian ini berfokus pada bukan hanya matakuliah pengantar ekonomi saja melainkan beberapa matakuliah. Bila memungkinkan pada perubahan kurikulum. Kata kunci: Kompetensi dosen, Motivasi belajar mahasiswa, Prestasi belajar mahasiswa
Analisis Tingkat Kualitas Produk dan Tingkat Pelayanan Kentucky Fried Chicken (KFC) Cabang Palembang Trade Centre
Authors: Oktavianti Santi
Published: August 2019

Tujuan penelitian – This research to identify and analyze the level of product quality and service level of Kentucky Fried Chicken (KFC) branch of the Palembang Trade Center Desain/Metodologi/Pendekatan – The variables used in this study is the level of product quality and service quality levels. The analytic technique used in this research is descriptive quantitative analysis Temuan – Based on the survey result revealed that the analysis of the level of product quality and service level of Kentucky Fried Chicken (KFC) in Palembang Branch Trade positive effect on service, this sesuiai with the consumer demand in expect include: KFC halal certified chicken, flavored chicken meat that is tender and delicious, as well as the packaging of products is good. Based on the results of the quality of service, consumers are comfortable with employees who are always friendly when ordering food and sprightly in helping consumers, as well as adequate facilities such as air conditioning, clean Restrooms, free parking and there are several restaurants in the arena children's play area Keterbatasan penelitian – Originality/value – Keywords : The level of product quality and service level
Comparative Study on NDVI with RVI for Estimated Area and Class Distribution
Authors: Yuliara I Made , Ratini Ni Nyoman , Kasmawan I Gde Antha
Published: August 2019

This study aims to determine the differences and comparison of the results of the estimated area, the distribution of clove vegetation using the Normalized Difference Vegetation Index (NDVI) and Ratio Vegetation Index (RVI) and to choose a vegetation index that is more suitable for clove vegetation analysis in Buleleng district, Bali. The method used is to compare statistically descriptive area and distribution class produced by the NDVI and RVI models with area data from the Forestry and Plantation Service (FPS), Buleleng regency, Bali in 2014, amounting to 7622.32 ha. The estimated area of ??clove vegetation by the NDVI model was 7852.68 ha and the RVI model was 7669.44 ha. There is an estimated difference in the area of ??clove vegetation of 183.24 ha and a difference in the broad class category of 2453.85 ha for the Rare class (NDVI > RVI) category, for the Medium class of 1611.45 ha (RVI > NDVI), and for the Dense class of 659.16 ha (RVI > NDVI). Comparison of the area with FPS data obtained 97.07% for the NDVI model and 99.39% for the RVI model. This shows that the RVI model vegetation index is more suitable for use in the estimation of the area and class of clove vegetation distribution in Buleleng regency, Bali.
A situação atual do ensino de Língua Estrangeira nas escolas públicas de Dourados - MS
Authors: Matos Valéria Sales Menezes
Published: August 2019

O presente artigo tem como objetivo analisar a atual situação do ensino de língua estrangeira no cenário educacional de Dourados - Mato Grosso do Sul. Para tal, evidencia-se o panorama histórico do ensino de línguas estrangeiras no Brasil, bem como suas normas e orientações sugeridas pelos Parâmetros Curriculares Nacionais do Ensino Médio quanto a este ensino; destacamos, ainda, o engajamento do professor de línguas estrangeiras. Para esta análise foram feitas entrevistas em escolas públicas da cidade, com foco no ensino médio.
As dificuldades pedagógicas em diversas fases da carreira de professores de educação física na educação básica
Authors: Krug Hugo Norberto , Krug Rodrigo De Rosso , Krug Marilia De Rosso , Krug Moane Marchesan , Telles Cassiano
Published: August 2019

O estudo objetivou identificar e analisar as percepções de professores de Educação Física (EF) da Educação Básica (EB), de uma rede de ensino público, de uma cidade do interior do estado do Rio Grande do Sul (Brasil), em diferentes fases na carreira docente, sobre as suas dificuldades pedagógicas no cotidiano escolar. Caracterizamos a pesquisa como qualitativa do tipo estudo de caso. O instrumento de pesquisa foi um questionário. A interpretação das informações coletadas foi por meio da análise de conteúdo. Participaram vinte e cinco professores de EF da EB da referida rede de ensino e cidade, sendo cinco de cada fase da carreira docente (entrada; estabilização; diversificação; serenidade e/ou conservantismo; e, desinvestimento). Concluímos que, as dificuldades pedagógicas no cotidiano escolar permeiam todas as fases da carreira dos professores de EF da EB e que as principais foram “as condições de trabalho difíceis/precárias”, “o baixo salário” e “a indisciplina dos alunos”.
Atenção à saúde de pessoas com síndrome de down na educação escolar: estudo de propostas para práticas corporais
Authors: Passos-Santos João Paulo dos , Molena-Fernandes Carlos Alexandre
Published: August 2019

Este artigo objetivou analisar indicadores de obesidade geral e central em pessoas com síndrome de Down (PCSD), matriculadas em uma escola que atende na modalidade de educação especial e apresentar possíveis práticas corporais presentes na literatura. A amostra foi constituída por 23 pessoas de 2 a 49 anos, sendo 9 do sexo masculino e 14 do feminino. O IMC apresentou alteração em 52,37% e a cintura em 21,74%. O sexo feminino obteve 55,56% e o masculino 50% de excesso de peso, porém, a diferença não foi significativa. Na circunferência da cintura 28,57% e 11,11%, respectivamente sexo feminino e masculino, e também não houve significância. Como grande parte apresentou excesso de peso, a literatura mostra que exercícios resistidos proporcionam grande melhora na composição corporal de PCSD.
Sobre as práticas pedagógicas na/da creche: perspectivas das profissionais do município de Corumbá/MS
Authors: Silva Ingrid Loraini de Alencar da , Almeida Vanessa De , Rodrigues Sílvia Adriana
Published: August 2019

O presente artigo é um recorte da pesquisa desenvolvida no âmbito do Grupo de Estudos e Pesquisas sobre Infância e Educação Infantil - GEPIEI da Universidade Federal do Mato Grosso do Sul/Campus do Pantanal (UFMS/CPAN), que teve como objetivo geral compreender alguns aspectos do trabalho pedagógico desenvolvido com as crianças de 0 a 3 anos nas creches do município de Corumbá-MS. Assim, aqui discutiremos as concepções de prática pedagógica na creche das profissionais que nela atuam; tendo como instrumento de coleta de dados questionário misto, composto por 21 questões, tivemos como sujeitos da investigação 80 profissionais atuantes nas creches da cidade em questão (51% do total). A análise dos dados recolhidos não nos permite afirmar que há práticas pedagógicas de excelência nas creches do município; há um percentual interessante de respostas bastante positivas que indicam passos na direção certa. No entanto, também aparecem afirmações que indicam que as profissionais participantes do estudo não compreendem perfeitamente as características infantis, bem como ainda mantém uma visão assistencialista do papel e função da instituição e consequentemente do trabalho a ser realizado por eles.
A panacea for improving citizen behaviors? Introduction to the symposium on the use of social norms in public administration
Authors: John Peter , Sanders Michael , Wang Jennifer
Published: August 2019

Recent years have seen a growth in the use of social norm messages by local and national governments across the world. These messages have primarily been used to induce desired behaviors among the non-compliant minority by pointing to the compliance of the majority. As well as being of considerable theoretical interest, these messages have a high level of empirical and experimental support in government settings as well as a few null and negative findings. In this introduction to the symposium, we offer an overview of research to date using social norms in public administration, reviewing what ‘stylized facts’ emerge, then introduce the articles included in the symposium.
Correlation of Tumor Marker Cancer Antigen (CA-125) against Hemoglobin, Leucocytes, and Platelet Lymphocyte Ratio in Ovarian Cancer Patients at RSUD ULIN Banjarmasin
Authors: Sabarudin Hermin
Published: August 2019

CA-125 is the most commonly used tumor marker in ovarian cancer, its known as the "Gold Standard" for the diagnosis of ovarian cancer. CA-125 allegely related to the inflammatory mechanisms which associated with leukocytes and lymphocytes, as well as Lymphocyte Platelet Ratio. This study is to prove above hypothesis. The objective is to investigate CA-125 correlation as tumor marker of inflammatory hematology examination which consisting of Hemoglobin, leucocytes and PLR as indicator of inflammatory examination in ovarian cancer patient. The method is an observational analytic study with cross sectional retrospective descriptive. The sample is 42 patients medical record who are treated in Oncology Polyclinic RSUD ULIN in October 2014 - October 2017 period. Samples selected by time limitation method. Sampling technique using nonpropability method followed by purposive sampling method. After the data is taken and selected then processed into SPSS for normality test and continued by multiple linear regression test. The results showed that correlation analysis of CA-125 tumor marker on Hb, leukocyte and PLR levels was P = 858b; P value <0.05. The CA-125 relationship to Hb, leucocytes and PLR is a negative relationship (r Hb = -3,463, r leukocytes = -6,117, r PLR = -2.281), which means that more high the Hb, leukocyte and PLR value, conversely CA125 value become more low. The conclusions of this study is there no correlation of CA125 tumor marker against Hb, leucocytes and PLR in ovarian cancer patients. The results of this study indicate that the increasing of CA125 value is negative correlation because it is not followed by decreasing of Hb, increasing of leukocyte and PLR.
Pharmacogenomics Statins: Biomarkers for Clinical Prediction
Authors: Suprapti Herni
Published: August 2019

Statins are the most widely prescribed drug for hyperlipidemic therapy and for the prevention of Cardiovascular disease. But although statins are very effective for the prevention of atherosclerosis, there are still patients with CVD. In this case, it is thought to be the influence of genetic factors. There is a static gene link to statin dose required for therapy, but there are still no relevant pharmacogenomic tests for statin therapy guidelines. This article describes basic pharmacogenomic terminology, genes (CETP, HMGCR, SLCO1B1, ABCB1, and CYP3A4 / 5), and progression of statin pharmacogenomic biomarkers for predicted therapeutic outcomes.
Efek Abelmoschus esculentus terhadap Glukosa Darah, Superoksida Dismutase, dan Malondialdehid Rattus norvegicus Diabetes Melitus dengan Induksi Streptozotocin
Authors: Herliani Olivia
Published: August 2019

In diabetes mellitus there is an increase in oxidative stress in which oxidants exceed the antioxidant system resulting from the production of oxidant-antioxidant imbalance and/or limited antioxidant defenses. Abelmoschus esculentus (“okra”) is known as lowering blood glucose vegetable by Indonesian. A. esculentus has a high antioxidant activity that can: 1) lower H2O2 level; 2) decrease the amount of ROS; 3) lower •OH level. This study tried to prove that administration of A. esculentus may decrease fasting blood glucose, serum malondialdehyde, and increase superoxide dismutase activity of diabetic male white rats. This research is a pure experimental research, with randomized post test only control group designs, held in 28 days. Thirty one rats were divided into 4 groups randomly: KN = normal control group given 0.1% Na-CMC solution; KDM = DM control group injected with STZ, followed by 0.1% Na-CMC solution; P1 = treatment group 1 injected with STZ, followed by administration of A. esculentus at a dose of 775 mg/kgBW/day; P2 = treatment group 2 injected with STZ, followed by administration of A. esculentus at a dose of 1550 mg/kgBW/day. The result: administration of A. esculentus at doses of 775 mg/kgBW/day and 1550 mg/kgBW/day can not decrease fasting blood glucose and MDA serum level of diabetic male white rats. Giving A. esculentus at a dose of 1550 mg/kgBW/day may increase the activity of SOD erythrocytes of diabetic male white rats.. Conclusions: A. esculentus has the potential to lower blood glucose and MDA serum levels, also increase erythrocyte SOD activity.
Disease Patterns in The Baksos Service Community to Improve Efficient ad Better Quality
Authors: Soesanto Danoe
Published: August 2019

Recently there are still many community organizations, educational institutions and political organizations conducting free medical service activities, the purpose of that activities varying depend on the organization. The purpose of this study was to described the implementation and outcomes (the number of people served, gender, characteristics of age and what diseases is the most) that activities, Methods of This study was  a non-experimental research, researcher just observed the subject without  manipulated or intervention. Result of this study was found the number of women 57.71% and the late adult age to > 65 years old more served during social health service activities, whereas most types of diseases were myalgia 24.09% and hypertension 22.40%. Free medical service activities activity still needed by society but for management of non communicable disease need to reevaluated especially problem of monitoring result of treatment and preventive action which can be done but more cost effective compared with curative action. Further research needed about benefit, the impact and effectiveness of charity medical care activities and the cost comparisonbetween curative efforts and preventive efforts in dealing with hypertension.
МОДЕЛЬ ФОРМУВАННЯ ОПТИМАЛЬНОЇ ІЄРАРХІЇ ЦІЛЕЙ ФУНКЦІОНУВАННЯ ПІДПРИЄМСТВ ГОТЕЛЬНО-РЕСТОРАННОЇ ІНДУСТРІЇ
Authors: Шевчук Юлія Андріївна
Published: August 2019

The article presents the research findings on building an optimal goal hierarchy for businesses in the sector of hotel and restaurant industry. A mathematical rationale has been provided for setting objectives in the context of ensuring effective hospitality management by hotel and restaurant businesses based on a set of key performance indicators. It is argued that every managerial action must be focused on problem solving. According to the research results, a solution is a management decision aimed at gaining the maximum to achieve certain goals. Failure to set optimal goals makes impossible to shape a management problem which, in turn, translates into absence of the need for making management decisions. Goals contribute to shaping the criteria for evaluating the feasibility of proposed management decisions as well as mapping the criteria for assessing the ultimate predicted outcomes. However, most often, objectives sought to be achieved by top management of hospitality industry companies are perceived quite differently by the staff. In this context, the system of goals is a critical instrument for management decision making and problem solving related to organizational issues in managing businesses of hotel and restaurant industry. Thus, the flexibility of organizational structures in a management paradigm within the hospitality industry is associated with the dynamic process of designing the optimal goal hierarchy to achieve good performance in the sector of hotel and restaurant industry. The author assumes that the estimation of the relevant flexibility of organizational structure management by hospitality industry businesses can be attained through the suggested classification of management goals.
TATA KRAMA DALAM ADAT ISTIADAT ORANG KATOBENGKE DI KOTA BAU-BAU PROVINSI SULAWESI TENGGARA
Authors: Raodah Raodah
Published: August 2019

Tata krama dalam adat istiadat orang Katobengke mencerminkan perilaku mereka dalam kehidupan sehari-hari dalam berinteraksi. Tulisan ini bertujuan untuk mengetahui dan mendeskripsikan bentuk-bentuk tata krama orang Katobengke dalam lingkup keluarga dan masyarakat, serta tata krama dalam berbagai upacara adat. Metode yang digunakan dalam penelitian ini bersifat deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data melalui observasi dengan penentuan lokasi secara purposive, wawancara mendalam dengan informan yang dipilih secara acak dari tokoh adat, parabela, imam kampung, dan warga Katobengke, serta teknik dokumentasi. Hasil penelitian menggambarkan bahwa tata krama orang Katobengke sangat dipengaruhi oleh norma adat yang berlaku, dan sesuai tuntunan parabela selaku ketua adat. Bentuk-bentuk tata krama dalam pergaulan dan kehidupan sehari-hari meliputi tata krama dalam menyapa dan bersikap, tata krama duduk, makan dan minum, berpakaian serta berinteraksi dengan masyarakat. Sedang tata krama dalam upacara adat (haruo) meliputi: Tuturangi Lipu Morikana, Posuo, upacara perkawinan, dan beberapa ritual adat yang masih berpegang teguh sesuai ajaran leluhur orang Katobengke.Manners in the customs of the Katobengke people reflect their behavior in daily life. This paper aims to find out and describe the form of Katobengke manners within family and community, as well as manners in various traditional ceremonies. The method used in this study is descriptive with a qualitative approach. Data collection techniques are carried out through field observation by determining the location in a purposive manner, depth interviews with informans randomly selected from traditional leaders, parabela, village priests, and residents of Katobengke, as well as documentation techniques. The results of the study illustrate that manners of Katobengke people are strongly influenced by the custumory norms that apply and in accordance with parabela guidance as customary leader. The forms of manners in society and daily life include manners in greeting and behaving, manners of sitting, dressing, eating and drinking, as well as interacting with community; while manners in traditional ceremonies include Tuturangi Lipu Morikana, Posuo, marriage ceremonies, and some traditional rituals, which still adhere to the ancestors teaching of Katobengke people.
BETUTU BALI : MENUJU KULINER DIPLOMASI BUDAYA INDONESIA
Authors: Purna I Made , Dwikayana Kadek
Published: August 2019

Etnis Bali yang beragama Hindu, telah memiliki sumber daya budaya berupa kuliner tradisional betutu dari bahan ayam dan bebek. Kuliner betutu dimasak dengan bumbu “jangkep” (lengkap). Kuliner ini pada awalnya difungsikan sebagai makanan persembahan terhadap Ida Hyang Widhi Wasa/Tuhan Hyang Maha Esa, dan hasil persembahannya disantap bersama-sama. Namun, perkembangan selanjutnya difungsikan sebagai hidangan kaum raja-raja dan keluarganya, dan kebutuhan sosial. Dalam menghadapi politik  global dan pariwisata, maka Betutu difungsikan sebagai kebutuhan biologis anggota masyarakat secara umum, pariwisata dan diplomasi. Tujuan dari penulisan artikel ini (1) melestarikan kuliner Betutu Bali (2) mempopulerkan kuliner Betutu sebagai media identitas, toleransi (kerukunan, keharmonisan) antar umat beragama, etnis dan bangsa. Artikel ini menggunakan konsep kuliner, gastro diplomasi dan teori fungsional. Metode yang digunakan dalam penelitian ini menggunakan metode kualitatif deskriptif dengan teknik sampling menggunakan purposive sampling dan snowball sampling. Hasil penelitian ini menunjukkan kuliner Betutu dapat diterima oleh semua kalangan dengan terbukti dapat ditemukan atau disajikan di hotel-hotel berbintang, restauran, dijual di warung-warung makanan dengan omset yang selalu meningkat.Hindus Balinese ethnic has cultural resources in the form of betutu, a traditional culinary from chicken and duck. Betutu is cooked with "jangkep" (complete) spices. This food was originally functioned as a food offering to Ida Hyang Widhi Wasa (Hyang the One God), and the results of her offerings were eaten together. However, further developments functioned as a dish for the kings and their families, and social needs. In the face of global politics and tourism, Betutu functioned as the biological needs of community members in general, tourism and diplomacy. The purpose of writing this  are (1) preserving Betutu Bali culinary (2) popularizing Betutu culinary as a medium of identity, tolerance (harmony) between religious and ethnic groups. This article uses concepts such as culinary, gastro diplomacy and functional theory. This study uses descriptive qualitative methods with sampling techniques like purposive sampling and snowball sampling. The results of this study show that Betutu culinary can be accepted by all people, proven to be found or served in starred hotels, restaurants, sold in food stalls with an ever-increasing turnover.
Genotypic and phenotypic variation of CADASIL among Chinese, Indians and Rungus in Malaysia
Authors: Toh Tsun Haw , Lim Kheng Seang , Ng Ching Ching , Idris Imran , Ahmad Sherrini Bazir , Lim Thien Thien , Looi Irene , Tan Ai Huey , Chan Chung Kin , Lim Chun Shen , Tan Chong Tin
Published: August 2019

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease of small cerebral arteries. This case series aims to describe the mutations in NOTCH3 and their phenotypes in Malaysia. We included patients who were genetically confirmed to have CADASIL, diagnosed at the University of Malaya Medical Centre, Malaysia. Family members who fulfilled clinical or imaging criteria, and patients from two previous published Malaysian families were also included. Six families (eleven cases) were included in this series. Genetic testing revealed NOTCH3 mutations in c.328C>T (p.Arg110Cys, R110C), c.533T>G (p.Cys185Gly, C185G), c.1630C>T (p.Arg544Cys, R544C) and c.160C>T (p.Arg54Cys, R54C). Two out of four Chinese families had R544C mutation in exon 11, with a later age of onset, absence of migraine and lack of anterior temporal pole involvement on MRI. One family with mixed Indian and Chinese ancestry had a mutation in exon 3 with R110C and another Indian family exon 4 with C185G mutation. This case series highlights the genotypic and phenotypic variability of CADASIL in a multiethnic country. The finding of p.Arg544Cys mutation among the older Chinese families, similar to those reported in Jeju Island and Taiwan, suggest the need to screen the older Chinese stroke patients with typical MRI changes.
The axiom of selection resolves Russell’s paradox
Authors: Lobo Matheus Pereira
Published: August 2019

We show that the axiom of selection solves Russell's paradox.
Design of the Energy Storages for a (Battery) Electric Commuter Train
Authors: Schmetz Roland , Struck Alexander
Published: August 2019

The use of battery-powered electric commuter trains instead of those which are propelled by internal combustion engines on only partially (or non) electrified railway lines can save considerable amounts of energy and can avoid exhaust emissions to a large extent with comparatively low investment costs. As path to these goals, the railway line, the operating and the trains are modeled for a particularly interesting, real-life example. Then, for the generated models, it is shown how the energy demands of model-compliant (battery) electric commuter trains can be calculated and how their energy storages can be designed. The models and the procedure can also be applied for a large number of comparable dimensioning cases when defining further railway lines, operating and commuter train models, corresponding parameterization as well as the occasionally necessary addition of slope and curvature resistances. The calculation of energy demands and the design of energy storages, however, show that there are a large number of different alternatives for technical specifications as well as decisions relevant to energy efficiency and business management, too. To determine the most suitable solutions, further measures such as the investigation of the effects of intelligent modifications to the underlying models, the development and implementation of computer-aided simulations as well as the construction and testing of real (battery) electric commuter trains make sense.
The Inertia of Light. Newton's Law in 4 Dimensions.
Authors: Vegt Wim
Published: August 2019

Isaac Newton and James Clerk Maxwell were giants in the history of physics. Newton in his century (1643 – 1727) and Maxwell about 150 years later (1831 – 1879) in his own century. Newton has built his theories, based on the deep and profound wisdom in nature and religion. For this reason, Newton has been called the last magician in his time. Maxwell represents modern physics and he has built his theories only on pure mathematics. Based on Newtonian Physics it is possible to reach much further in physics than the achievements based on a simple Maxwell’s mathematical approach. Newtonian Physics gives a new insight in the fundamental physics of Light, Electromagnetic Fields, Dirac’s relativistic Quantum Physics and Einstein’s General Relativity. All we know about light, and in general about any electromagnetic field configuration, has been based only on two fundamental theories. James Clerk Maxwell introduced in 1865 the “Theory of Electrodynamics” with the publication: “A Dynamical Theory of the Electromagnetic Field” and Albert Einstein introduced in 1905 the “Theory of Special Relativity” with the publication: “On the Electrodynamics of Moving Bodies” and in 1913 the “Theory of General Relativity” with the publication ”Outline of a Generalized Theory of Relativity and of a Theory of Gravitation”. However, both theories are not capable to explain the property of electromagnetic mass and in specific the anisotropy of the phenomenon of electromagnetic mass. To understand what electromagnetic inertia and the corresponding electromagnetic mass is and how the anisotropy of electromagnetic mass can be explained and how it has to be defined, a New Theory about Light has to be developed. A part of this New Theory about Light will be published in this article.The New Theory about Light has been based on one single fundamental property of our Universe. The unique property that there has always been, is always and will always be a perfect equilibrium within our Universe. Isaac Newton has discovered this fundamental physical law already 300 years ago by his third law in physics. “For every action there is an equal and opposite reaction”. In the New Theory this law of Equilibrium has been extended for any arbitrary Electromagnetic Field Configuration, which requires the fundamental Universal Property: “The total algebraic sum of all force densities will always equal zero at any time at any spatial coordinate in any spatial direction”. To develop a set of 4 electromagnetic equations, describing all the force densities within any arbitrary electromagnetic field configuration, the Divergence of the 4-Dimensional Stress-Energy Tensor has been taken, resulting in the 4-Dimensional Electromagnetic Vector Equation with the fundamental requirement: “The the total algebraic sum of all force densities equals zero at any time at any spatial coordinate in any spatial direction”
Detection of data fabrication using statistical tools
Authors: Hartgerink Chris Hubertus Joseph , Voelkel Jan G. , Wicherts Jelte M. , van Assen Marcel A. L. M.
Published: August 2019

Scientific misconduct potentially invalidates findings in many scientific fields. Improved detection of unethical practices like data fabrication is considered to deter such practices. In two studies, we investigated the diagnostic performance of various statistical methods to detect fabricated quantitative data from psychological research. In Study 1, we tested the validity of statistical methods to detect fabricated data at the study level using summary statistics. Using (arguably) genuine data from the Many Labs 1 project on the anchoring effect (k=36) and fabricated data for the same effect by our participants (k=39), we tested the validity of our newly proposed 'reversed Fisher method', variance analyses, and extreme effect sizes, and a combination of these three indicators using the original Fisher method. Results indicate that the variance analyses perform fairly well when the homogeneity of population variances is accounted for and that extreme effect sizes perform similarly well in distinguishing genuine from fabricated data. The performance of the 'reversed Fisher method' was poor and depended on the types of tests included. In Study 2, we tested the validity of statistical methods to detect fabricated data using raw data. Using (arguably) genuine data from the Many Labs 3 project on the classic Stroop task (k=21) and fabricated data for the same effect by our participants (k=28), we investigated the performance of digit analyses, variance analyses, multivariate associations, and extreme effect sizes, and a combination of these four methods using the original Fisher method. Results indicate that variance analyses, extreme effect sizes, and multivariate associations perform fairly well to excellent in detecting fabricated data using raw data, while digit analyses perform at chance levels. The two studies provide mixed results on how the use of random number generators affects the detection of data fabrication. Ultimately, we consider the variance analyses, effect sizes, and multivariate associations valuable tools to detect potential data anomalies in empirical (summary or raw) data. However, we argue against widespread (possible automatic) application of these tools, because some fabricated data may be irregular in one aspect but not in another. Considering how violations of the assumptions of fabrication detection methods may yield high false positive or false negative probabilities, we recommend comparing potentially fabricated data to genuine data on the same topic.
Brief Report: Exploring Some Aspects of Social Activism in the Online Autistic Community
Authors: Bolton Matthew J. , Ault Lara K.
Published: August 2019

The socio-political landscape surrounding autism, a set of neurological conditions existing on a spectrum and marked by difficulties in socializing, narrow interests, repetitive behaviors, and sensory sensitivities, has seen the neurodiversity social movement emerge with the perspective that neurological conditions represent normative differences rather than abnormality. Despite the movement, however, autistic people (we use both identity- and person-first language in our work, to respect the multiple language perspectives of people on the spectrum) still struggle with overt stigmatization. The present study tested the prediction that perceived discrimination–the extent to which individuals are aware of others’ negative views of their own group–would be related to higher levels of internalized stigma (the incorporation of stereotypes about one’s group into one’s identity), broad social activism, and autism/disability-related advocacy. Results partially supported hypotheses: Perceived discrimination and internalized stigma were negatively correlated, r(80) = -.55, p < .001; and general social-issues advocacy was negatively correlated with self-reported importance of disability, r(80) = -.22, p < .05 and autism-specific activism, r(80) = -.32, p < .01. In support, however, perceived discrimination correlated positively with the importance of autism-specific activism, r(80) = .38, p < .01, and with importance of general disability advocacy, r(80) =.28, p < .05. Hence, autistic people who valued activism reported engaging less in broad social-issues advocacy, but more in disability- and autism-related advocacy, and tended to perceive discrimination but not to internalize stigma. Implications for the activist online autistic community and future population-specific scale development are discussed.