bluuebunny/crossref_metadata_2025 huggingface dataset:
Visible-light mediated 3-component synthesis of sulfonylated coumarins from sulfur dioxide
Authors: Chen Zhengkai , Liu Nai-Wei , Bolte Michael , Ren Hongjun , Manolikakes Georg
Published: June 2018

Visible light can be used as a sole driving force for the fixation of sulfur dioxide into sulfonylated coumarins.
An uncondensed lignin depolymerized in the solid state and isolated from lignocellulosic biomass: a mechanistic study
Authors: Li Ning , Li Yanding , Yoo Chang Geun , Yang Xiaohui , Lin Xuliang , Ralph John , Pan Xuejun
Published: June 2018

Lignin was depolymerized in the solid state and separated from lignocellulosic biomass in high-purity and in a less condensed form for valorization.
Metal-free benzannulation of yne-allenone esters for atom economical synthesis of functionalized 1-naphthols
Authors: Sha Hong-Kai , Liu Feng , Lu Juan , Liu Zhang-Qin , Hao Wen-Juan , Tang Jia-Le , Tu Shu-Jiang , Jiang Bo
Published: June 2018

A metal-free benzannulation reaction of yne-allenone esters with H2O or aromatic amines in the presence of HOAc is reported, providing an atom economical protocol toward functionalized 1-naphthols with good to excellent yields.
Structural motif, topi and its role in protein function and fibrillation
Authors: Dhar Jesmita , Chakrabarti Pinak
Published: June 2018

The structural motif, topi, is observed in the active site of some native proteins and the fibrillar form of misfolded proteins.
Multi-functional neuroprotective activity of neohesperidin dihydrochalcone: a novel scaffold for Alzheimer's disease therapeutics identified via drug repurposing screening
Authors: Chakraborty Sandipan , Rakshit Jyotirmoy , Bandyopadhyay Jaya , Basu Soumalee
Published: June 2018

Multi-target screening identifies neohesperidin dihydrochalcone for Alzheimer's disease therapeutics, which exhibits strong BACE1 and amyloid aggregation inhibition along with antioxidant activity.
Effect of the π-linker on the performance of organic photovoltaic devices based on push–pull D–π–A molecules
Authors: Lim Hong Chul , Kim Jang-Joo , Jang Jyongsik , Hong Jong-In
Published: June 2018

The bulk heterojunction organic photovoltaic (OPV) devices based on 3T : PC71BM (2 wt%, 1 : 1.75 w/w) exhibited a higher power conversion efficiency of 2.58% than DTT-based OPV devices.
High strength and anti-fatigue nanocomposite hydrogels prepared via self-initiated free radical polymerization triggered by daylight
Authors: Xu Bo , Liu Yuwei , Li Yu , Wang Lanlan , Li Nannan , Fu Min , Wang Ping , Wang Qiang
Published: June 2018

A new type of high strength nanocomposite hydrogel was synthesized using TiO2 nanoparticles as both cross-linkers and photo-initiators under daylight.
Unexpected C–N bond formation via Smiles rearrangement: one pot synthesis of N-arylated coumarin/pyran derivatives
Authors: Kumar K. Shiva , Ramulu Meesa Siddi , Kumar N. Praveen
Published: June 2018

A conceptually new and one-pot method for the synthesis of N-arylated coumarin/pyran derivatives via Smiles rearrangement.
Fabrication of an Ag/Ag2MoO4plasmonic photocatalyst with enhanced photocatalytic performance for the degradation of ciprofloxacin
Authors: Li Jin , Liu Feng , Li Yuanrui
Published: June 2018

The Ag/Ag2MoO4photocatalyst exhibited high photodegradation efficiency with 99.5% removal of CIP in 60 min and excellent stability in five consecutive cycles.
Stereocontrolled synthesis of polyhydroxylated bicyclic azetidines as a new class of iminosugars
Authors: Malinowski Maciej , Hensienne Raphaël , Kern Nicolas , Tardieu Damien , Bodlenner Anne , Hazelard Damien , Compain Philippe
Published: June 2018

First examples of a new class of constrained bicyclic iminosugars have been synthesized by a non-classical Dieckmann-like reaction.
Coordination-supported organic polymers: mesoporous inorganic–organic materials with preferred stability
Authors: Chen Dong , Zhang Pengfei , Fang Qianrong , Wan Shun , Li Hui , Yang Shize , Huang Caili , Dai Sheng
Published: June 2018

A simple and versatile strategy is developed for the synthesis of coordination-supported organic polymers(COPs) via coordination between Al3+ and 5-amino-8-hydroxyquinoline together with organic imine- or imide-based polycondensation.
Sulfur mediated propargylic C–H alkylation of alkynes
Authors: Hu Gang , Xu Jiaxi , Li Pingfan
Published: June 2018

Sulfur mediated propargylic C–H alkylation was realized through a one-pot procedure with modest yields and substrate scope. Hopefully, the community could find a better solution to this challenge by some novel metal-catalyzed reactions.
Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease
Authors: Shi Xue , Sun Ruimin , Zhao Yan , Fu Rong , Wang Ruiwen , Zhao Huanyu , Wang Zhecheng , Tang Fan , Zhang Ning , Tian Xiaofeng , Yao Jihong
Published: June 2018

Autophagosome and lysosome fusion was restored by salvianolic acid A-mediated SIRT1 up-regulation and protected against chronic ethanol-induced liver injury.
Preparation of polycarboxylic acid-functionalized silica supported Pt catalysts and their applications in alkene hydrosilylation
Authors: Shao Dongyun , Li Youxin
Published: June 2018

Three novel Pt catalysts were prepared by loading Pt onto aminopolycarboxylic acid functionalized silica gel and were used in alkene hydrosilylation.
Synthesis of sulfamic acid supported on Cr-MIL-101 as a heterogeneous acid catalyst and efficient adsorbent for methyl orange dye
Authors: El-Hakam Sohier A. , Samra Salem E. , El-Dafrawy Shady M. , Ibrahim Amr A. , Salama Reda S. , Ahmed Awad I.
Published: June 2018

Sulfamic acid was incorporated into MIL-101 (Cr). The samples exhibited excellent adsorption performance for MO dye and acted as heterogeneous catalysts for coumarin and xanthene synthesis.
Improving the photocatalytic reduction of CO2to CO for TiO2hollow spheres through hybridization with a cobalt complex
Authors: Lin Jinliang , Sun Xiaoxiang , Qin Biao , Yu Ting
Published: June 2018

A chemical system with enhanced efficiency for electron generation and transfer was constructed by the integration of TiO2hollow spheres with [Co(bipy)3]2+.
Synthesis of phosphine oxide based amphiphilic molecules via ring-opening Wittig olefination of a macrocyclic phosphoranylidene and their property study as non-ionic surfactants
Authors: Xu Jin , Chen Anqi , Burkett Brendan , Ng Qi Hua , Chan Kok Ping
Published: June 2018

A novel ring-opening Wittig olefination approach was developed for the synthesis of amphiphilic phosphine oxides (PO) as non-ionic surfactants.
Biomimetic enzyme-linked immunoassay based on a molecularly imprinted 96-well plate for the determination of triazophos residues in real samples
Authors: Hong Sihui , She Yongxin , Cao Xiaolin , Wang Miao , Zhang Chao , Zheng Lufei , Wang Shanshan , Ma Xingbin , Shao Hua , Jin Maojun , Jin Fen , Wang Jing
Published: June 2018

In this study, a direct competitive biomimetic enzyme-linked immune-sorbent assay (BELISA) based on a molecularly imprinted nanomembrane as an artificial antibody was developed for the determination of triazophos in real samples.
Quantum confined two-dimensional electron/hole gas switching by facet orientation of perovskite oxides
Authors: Zhou Fei , Liu Yong , Lai Zhonghong , Liao Mingqing , Zhou Yi , Huang Yudong , Zhu Jingchuan
Published: June 2018

The Polar discontinuity at heterointerface and the bare surface reconstructs the electronic phase of perovskite oxides.
Optically active distorted cyclic triptycenes: chiral stationary phases for HPLC
Authors: Ikai Tomoyuki , Nagata Naoya , Awata Seiya , Wada Yuya , Maeda Katsuhiro , Mizuno Motohiro , Swager Timothy M.
Published: June 2018

We have succeeded in developing triptycene-based chiral stationary phases with a distorted cyclic structure, which can resolve a series of axially chiral compounds.
Flexible resistive switching bistable memory devices using ZnO nanoparticles embedded in polyvinyl alcohol (PVA) matrix and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS)
Authors: Hmar Jehova Jire L.
Published: June 2018

The results clearly show that there was no detectable change in resistive switching characteristics of non-volatile bistable memory device even after bending the device at different angles, making it compatible with flexible electronics.
One-pot synthesis of ordered nanoporous amorphous H-Zn-aluminosilicate for catalysis of bulky molecules
Authors: Diwakar Jitendra , Viswanadham Nagabhatla , Kumar Saurabh , Kumar Adarsh , Saxena Sandeep K.
Published: June 2018

We are reporting a simple one-pot synthesis method of nanoporous H-zinc-aluminosilicate (HZnAlSi) from a Na-free chemical mixture.
Experimental evaluation of additional short ranged repulsion in structural oscillation forces
Authors: Schön Sebastian , von Klitzing Regine
Published: June 2018

Identification of positive synergy at low ionic strength between structural oscillation and double layer forces in confined aqueous silica nanoparticle suspensions.
First achieving highly selective oxidation of aliphatic alcohols to aldehydes over photocatalysts
Authors: Xie Feng , Zhang Yin , He Xiao , Li Hongdong , Qiu Xueying , Zhou Wencai , Huo Shutong , Tang Zhiyong
Published: June 2018

Highly selective oxidation of aliphatic alcohols to aldehydes over bismuth oxyhalide photocatalysts is achieved for the first time.
A simple flash carbonization route for conversion of biomass to porous carbons with high CO2 storage capacity
Authors: Hirst Edward A. , Taylor Alison , Mokaya Robert
Published: June 2018

Flash carbonization is an attractive yet simple route for the preparation of biomass (sawdust) derived carbons that exhibit attractive CO2 uptake of up to 5.0 mmol g−1 (at 25 °C and 1 bar), and exceptional working capacity for pressure or vacuum swing adsorption processes under simulated flue gas conditions.
RhBMP-2 and concomitant rapid material degradation synergistically promote bone repair and regeneration with collagen–hydroxyapatite nanocomposites
Authors: Su Wen , Ma Xiaomin , Sun Zhe , Yi Zeng , Cui Xinxing , Chen Guangcan , Chen Xiangyu , Guo Bo , Li Xudong
Published: June 2018

Enhanced bone repair and regeneration were achieved by rhBMP-2 and concomitant rapid material degradation of collagen–hydroxyapatite nanocomposites.
Structural design of multilayer thermally conductive nanofibrillated cellulose hybrid film with electrically insulating and antistatic properties
Authors: Song Na , Pan Haidong , Liang Xiaofei , Cao Donglei , Shi Liyi , Ding Peng
Published: June 2018

We fabricate a thermally conductive, electrically insulating and environment-friendly composite as a thermal interface material (TIM) with excellent tensile strength for heat dissipation.
Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells
Authors: Bäder Selina , Glaubke Elina , Grüb Saskia , Muhs Stefanie , Wellbrock Jasmin , Nalaskowski Marcus , Lange Tobias , Windhorst Sabine
Published: June 2018

Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) exhibits oncogenic activity in lung cancer cells by regulating Ins(1,4,5)P3-mediated calcium release and cytoskeletal dynamics. Since, in normal cells, ITPKA is mainly expressed in the brain, it is an excellent target for selected therapy of lung cancer. However, ITPKB is strongly expressed in normal lung tissues, but is down-regulated in lung cancer cells by miR-375, assuming that ITPKB might have tumor suppressor activity. In addition, ITPKB binds to F-actin making it likely that, similar to ITPKA, it controls actin dynamics. Thus, the treatment of ITPKA-expressing lung cancer with ITPKA inhibitors simultaneously inhibiting ITPKB may counteract the therapy. Based on these considerations, we analyzed if ITPKB controls actin dynamics and if the protein reduces aggressive progression of lung cancer cells. We found that ITPKB bundled F-actin in cell-free systems. However, the stable expression of ITPKB in H1299 lung cancer cells, exhibiting very low endogenous ITPKB expression, had no significant effect on the actin structure. In addition, our data show that ITPKB negatively controls transmigration of H1299 cells in vitro by blocking Ins(1,4,5)P3-mediated calcium release. On the other hand, colony formation was stimulated by ITPKB, independent of Ins(1,4,5)P3-mediated calcium signals. However, dissemination of H1299 cells from the skin to the lung in NOD scid gamma mice was not significantly affected by ITPKB expression. In summary, ITPKB does not affect the cellular actin structure and does not suppress dissemination of human lung cancer cells in mice. Thus, our initial hypotheses that ITPKB exhibits tumor suppressor activity could not be supported.
The FAM83 family of proteins: from pseudo-PLDs to anchors for CK1 isoforms
Authors: Bozatzi Polyxeni , Sapkota Gopal P.
Published: June 2018

The eight members of the FAM83 (FAMily with sequence similarity 83) family of poorly characterised proteins are only present in vertebrates and are defined by the presence of the conserved DUF1669 domain of unknown function at their N-termini. The DUF1669 domain consists of a conserved phospholipase D (PLD)-like catalytic motif. However, the FAM83 proteins display no PLD catalytic (PLDc) activity, and the pseudo-PLDc motif present in each FAM83 member lacks the crucial elements of the native PLDc motif. In the absence of catalytic activity, it is likely that the DUF1669 domain has evolved to espouse novel function(s) in biology. Recent studies have indicated that the DUF1669 domain mediates the interaction with different isoforms of the CK1 (casein kinase 1) family of Ser/Thr protein kinases. In turn, different FAM83 proteins, which exhibit unique amino acid sequences outside the DUF1669 domain, deliver CK1 isoforms to unique subcellular compartments. One of the first protein kinases to be discovered, the CK1 isoforms are thought to be constitutively active and are known to control a plethora of biological processes. Yet, their regulation of kinase activity, substrate selectivity and subcellular localisation has remained a mystery. The emerging evidence now supports a central role for the DUF1669 domain, and the FAM83 proteins, in the regulation of CK1 biology.
Receptive Language Skills in Slovak-Speaking Children With Intellectual Disability: Understanding Words, Sentences, and Stories
Authors: Polišenská Kamila , Kapalková Svetlana , Novotková Monika
Published: June 2018

Purpose

The study aims to describe receptive language skills in children with intellectual disability (ID) and to contribute to the debate on deviant versus delayed language development. This is the 1st study of receptive skills in children with ID who speak a Slavic language, providing insight into how language development is affected by disability and also language typology.

Method

Twenty-eight Slovak-speaking children participated in the study (14 children with ID and 14 typically developing [TD] children matched on nonverbal reasoning abilities). The children were assessed by receptive language tasks targeting words, sentences, and stories, and the groups were compared quantitatively and qualitatively.

Results

The groups showed similar language profiles, with a better understanding of words, followed by sentences, with the poorest comprehension for stories. Nouns were comprehended better than verbs; sentence constructions also showed a qualitatively similar picture, although some dissimilarities emerged. Verb comprehension was strongly related to sentence comprehension in both groups and related to story comprehension in the TD group only.

Conclusion

The findings appear to support the view that receptive language skills follow the same developmental route in children with ID as seen in younger TD children, suggesting that language development is a robust process and does not seem to be differentially affected by ID even when delayed.
Duration and Voice Quality of Early Infant Vocalizations
Authors: Gregory Adele , Tabain Marija , Robb Michael
Published: June 2018

Purpose

Infant vocal durations have been studied from a variety of perspectives, including medical, social, and linguistic. The resultant developmental profile across the first 6 months of life, however, is still far from clear. The purpose of this study was to evaluate the durational properties of infant vocalizations from the unique perspective of voice quality. By considering an infant's modal and nonmodal voice qualities, the developmental range of vocalizations produced by infants during the early months of life was captured.

Method

Four Australian English–speaking infants were recorded for approximately 1 hr per week during the first 6 months of life. A total of 6,309 vocalizations were perceptually identified and labeled according to voice quality. The duration of each vocalization was subsequently measured.

Results

A nonlinear curve was evident for the duration of all vocalizations combined. Duration increased significantly between Months 3 and 5. Modal voice was the only voice quality that displayed a linear increase in duration across the study. All other voice qualities displayed polynomial trends.

Conclusions

Based on the current results, the inconsistent pattern of vocal duration development found previously can be reconciled when voice quality properties of vocalizations are taken into account. A nonlinear curve is evident when a broad corpus of infant vocalizations is used, whereas a narrow corpus containing predominantly modal vocalizations displays a linear trend. The results demonstrate the necessity of including nonmodal voice qualities in infant duration experiments so as to not overstate the linear nature of duration increases.
Synthesis and characterisation of polymer containing dye‐affinity ligand grafted to magnetic nanoparticles for enteric insulin delivery
Authors: Izadi Vahedi Babak , Heydarinasab Amir , Ahmad Panahi Homayon , Jahanshahi Mohsen
Published: June 2018

In the present work, a novel technique is reported for the surface grafting of polymer containing famous dye‐affinity, Procion blue MX‐R, onto modified iron oxide nanoparticles with 3‐mercaptopropyltrimethoxysilane. The grafted nanocarrier was synthesised by free radical polymerisation followed by coupling with Procion blue and then characterised by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis and also transmission electron microscopy. The grafted magnetic nanocarrier was used for enteric insulin delivery. The profile of the insulin uptake by synthesised nanocarrier indicated excellent accessibility of the polymer contains Procion blue. Scatchard analysis reflected that the capacity of the polymer containing dye‐affinity ligand nanocarrier was about 12 µmol g−1 at pH 5. The balance sorption information of insulin by polymer contains Procion blue nanocarrier which were verified by Freundlich, Temkin, Langmuir and Redlich–Peterson models. The magnetic nanocarrier showed maximum of 95% drug release in acidic medium of pH 1.2, and about 80% drug release was recorded in intestine medium of pH 7.4.
Encapsulation of supported g‐C3N4/Au with metal–organic frameworks for enhanced stability towards photocatalytic hydrogen evolution
Authors: Zhang Zewu , Wang Qikang , Wu Qiong , Rao Qingxu , Hang Zusheng , Bu Xiaohai , Shi Haojun
Published: June 2018

The supported graphitic‐carbon nitride (g‐C3N4)/Au composite has attracted considerable attention as an alternative visible‐light photocatalyst for hydrogen evolution reactions. However, the short‐term photocatalytic durability greatly limits their practical application. In this work, porous [Zn(BDC)(H2 O)2]n, which is a typical two‐dimensional metal–organic frameworks (MOFs), was used as the protecting material to encapsulate g‐C3N4/Au. The obtained g‐C3N4/Au@[Zn(BDC)(H2 O)2]n catalyst was composed of lamellar MOFs shells and g‐C3N4/Au cores. The catalysts exhibited an excellent catalytic activity and particularly superior stability as compared to the bare g‐C3N4/Au. The encapsulation method by using MOFs as the protective shell provides an alternative strategy for designing photocatalysts with high catalytic performance.
Anatomy of the massive star-forming region S106
Authors: Schneider N. , Röllig M. , Simon R. , Wiesemeyer H. , Gusdorf A. , Stutzki J. , Güsten R. , Bontemps S. , Comerón F. , Csengeri T. , Adams J. D. , Richter H.
Published: June 2018

The central area (40″  × 40″) of the bipolar nebula S106 was mapped in the [O I] line at 63.2 μm (4.74 THz) with high angular (6″) and spectral (0.24 MHz) resolution, using the GREAT heterodyne receiver on board SOFIA. The spatial and spectral emission distribution of [O I] is compared to emission in the CO 16 →15, [C II] 158 μm, and CO 11 →10 lines, mm-molecular lines, and continuum. The [O I] emission is composed of several velocity components in the range from –30 to 25 km s−1. The high-velocity blue- and red-shifted emission (v = −30 to –9 km s−1 and 8 to 25 km s−1) can be explained as arising from accelerated photodissociated gas associated with a dark lane close to the massive binary system S106 IR, and from shocks caused by the stellar wind and/or a disk–envelope interaction. At velocities from –9 to –4 km s−1 and from 0.5 to 8 km s−1 line wings are observed in most of the lines that we attribute to cooling in photodissociation regions (PDRs) created by the ionizing radiation impinging on the cavity walls. The velocity range from –4 to 0.5 km s−1 is dominated by emission from the clumpy molecular cloud, and the [O I], [C II], and high-J CO lines are excited in PDRs on clump surfaces that are illuminated by the central stars. Modelling the line emission in the different velocity ranges with the KOSMA-τ code constrains a radiation field χ of a few times 104 and densities n of a few times 104 cm−3. Considering self-absorption of the [O I] line results in higher densities (up to 106 cm−3) only for the gas component seen at high blue- and red velocities. We thus confirm the scenario found in other studies that the emission of these lines can be explained by a two-phase PDR, but attribute the high-density gas to the high-velocity component only. The dark lane has a mass of ~275 M⊙ and shows a velocity difference of ~1.4 km s−1 along its projected length of ~1 pc, determined from H13CO+ 1 →0 mapping. Its nature depends on the geometry and can be interpreted as a massive accretion flow (infall rate of ~2.5 × 10−4 M⊙ yr−1), or the remains of it, linked to S106 IR/FIR. The most likely explanation is that the binary system is at a stage of its evolution where gas accretion is counteracted by the stellar winds and radiation, leading to the very complex observed spatial and kinematic emission distribution of the various tracers.
Homo Virtualis: existence in Internet space
Authors: Bylieva Daria , Lobatyuk Victoria , Rubtsova Anna
Published: June 2018

Abstract. The study of a person existence in Internet space is certainly an actual task, since the Internet is not only a source of innovation, but also the cause of society’s transformations and the social and cultural problems that arise in connection with this. Computer network is global. It is used by people of different professions, age, level and nature of education, living around the world and belonging to different cultures. It complicates the problem of developing common standards of behavior, a system of norms and rules that could be widely accepted by all users. On the other hand, the Internet space can be viewed as a new form of existence where physical laws do not work, and in connection with this, social ones are often questioned. This paper focuses on how social norms regulate relations in Internet space. The authors represents the typology of deviant behavior in the network. The empirical basis of the research includes the sociological survey of students of the senior courses in the Institute of Computer Science and Technology of Peter the Great St. Petersburg Polytechnic University. Sociological survey allows to identify students’ understanding of Internet space. The selection of students is conditioned by the fact that IT professionals are considered simultaneously as ordinary users of the network and as future professionals in this field.
Digital technologies and higher education in Russia: new tools of development
Authors: Dmitrieva Tatiana , German Elena , Khvatova Tatiana
Published: June 2018

The article gives consideration to the main trends of development of the system of higher education under conditions of economics digitization. The influence of technological revolution on the social sphere of society (education, employment) and public services has been analyzed. Characteristics have been given to the state and basic problems of development of higher education under conditions of digital economics; the main tasks and the ways of solving them in the area of focus: human resources and education of the program “Digital economics” have been enumerated. Consideration has been given to the project of the new network University of National Technical Initiative for training in professions associated with the use of advanced production technologies, intellectualization and robotization of production; its basic goals, objectives and specific features: short life cycle and network principle of functioning have been described. A concept of open educational resources – a modern social technology of training has been disclosed.
Digital simulation of physical processes in vehicles engine power units
Authors: Hoodorozhkov Sergey , Krasilnikov Andrey , Zakhlebayev Evgeney
Published: June 2018

This article studies the issues of digital simulation of physical operating processes in vehicles transmission. Simulation of dynamic processes is carried out in power transmissions at the design stage. The procedure for using the digital packages such as MATLab – Simulink and Simscape was considered for the numerical simulation of dynamic processes in mechanical systems based on the example of the theoretical calculation of K-744 tractor transmission dynamics. A digital model of K-744 tractor transmission is constructed, its calculation scheme is given, the initial characteristics are determined. A digital model of the tractor engine was created by means of the Simulink package. A nature of change in tractor engine torqueis determined by it. The calculated analysis of normal transmission frequencies is performed. Forced torsional vibrations are calculated in the tractor change gearbox generated by the vehicle engine operation. The conditions of resonance in the transmission are analyzed. The unfavorable modes of joint operation of the engine and the gearbox are determined for K-744 tractor.
Technological development and income inequality: a role of financial market
Authors: Ichkitidze Yuri , Lushkin Anton , Ungvari Laslo , Akaeva Sadat
Published: June 2018

In this paper we study the effects of financial markets on an increase in income inequity. The notion, which is employed as a working hypothesis that the market equilibrium around the fair price and unbiased changes in prices has a neutral effect on inequity while the systematic underreaction accompanied by time trends contributes to its growth, has been considered. In order to check this hypothesis we have studied the long-term cycles in dynamics of the US stock index and income inequity and shown that the stock market growth observed in 1980-2017 is correlated to an increase in income inequity. The presence of causality in this relationship has been found through the evidence of systematic underreaction given by the share prices of fast-growing companies to the information about the diffusion of technological innovations. The research results prove that the free financial markets with technological development in progress contribute to instability, as they while enhancing income inequality increase the unemployment growth risks and require additional efforts from the state to redistribute income.
A fuzzy set model for assessment of a perspectives level for integration of new materials in industrial enterprise processes
Authors: Kasianenko Elena , Konnikov Evgenii , Lukashevich Nikita
Published: June 2018

The definition of effective improvement vectors is currently one of the most pressing challenges facing the industry representatives. The transition to the sixth technological mode effectively contributes to competition intensification in all markets of industrial products. This is largely due to the fact that existing process systems are at the peak of their effectiveness. Further development requires qualitative changes. However, the principal improvement is a long-term and high-risk process. For this reason the issue of creating effective models for assessment of the strategic lines of processes improvement becomes increasingly important for industrial enterprises. This article considers in details the vector of industrial enterprise processes improvement based on the integration of new materials. As a result, a model allowing to assess a perspectives level for integration of new materials in industrial enterprise processes is created.
An empirical study of information technology clusters and regional economic growth in Russia
Authors: Kudryavtseva Tatiana , Rodionov Dmitry , Skhvediani Angi
Published: June 2018

The paper is devoted to the identification of the “Information Technologies” cluster in the regions of the Russian Federation and verification of the assumption that there is an interaction between the degree of cluster representation in the region and the GRP size. The authors considered the main theoretical and methodological provisions concerning the identification of clusters with the Top-down approach. Based on the develops of M. Porter and G. Lindqvist, the “Information Technologies” cluster characteristics such as local content, size and focus were calculated for 80 regions of the Russian Federation. The conclusions about the specifics of the cluster development in the country were made. Using the methods of regression analysis, the authors tested a number of hypotheses and revealed the presence of a positive interaction between the GRP volume and the “Information Technologies” cluster presence in the regions of the Russian Federation, as well as the local content, size and focus of this cluster in the regions of the Russian Federation.
Wavelet-analysis of network traffic time-series for detection of attacks on digital production infrastructure
Authors: Lavrova Darya , Semyanov Pavel , Shtyrkina Anna , Zegzhda Peter
Published: June 2018

Digital production integrates with all the areas of human activity including critical industries, therefore the task of detecting network attacks has a key priority in protecting digital manufacture systems. This article offers an approach for analysis of digital production security based on evaluation of a posteriori probability for change point in time-series, which are based on the change point coefficient values of digital wavelet-transform in the network traffic time-series. These time-series make it possible to consider the network traffic from several points of view at the same time, which plays an important role in the task of detecting network attacks. The attack methods vary significantly; therefore, in order to detect them it is necessary to monitor different values of various traffic parameters. The proposed method has demonstrated its efficiency in detecting network service denial attacks (SlowLoris and HTTP DoS) being realized at the application level.
Ontology as mapping of material world
Authors: Leshcheva Irina , Leshchev Dmitry
Published: June 2018

This paper reviews currently available approaches and methods of automated population and enrichment of ontologies or ontology-based knowledge bases by structured data stored in various heterogeneous sources. Advantages and disadvantages of each approach are pointed out. The results of the analysis allow concluding that the existing methods are not effective enough to solve practical problems. A new method suggested does not have any of the specified disadvantages. The suggested method allows integrating data from different types of sources and considering the distributed nature of data and the necessity of authentication during accessing network resources. The method also suggests a solution to the problem of integrated data conflict resolution so that it will reduce the complexity of populating and enriching ontologies using the collected data arrays, irrespective of the format in which data are stored or represented.
A processing center for using digital hybrid technologies
Authors: Masailo Dmitry , Orlov Alexey , Sufiyarov Vadim , Volkov Andrey
Published: June 2018

The role of additive technologies in industrial development was highlighted, in particular, for implementation of the concept “Industry 4.0”. We discussed their significance for digital manufacturing of parts having complex configuration with internal cavities and functionally gradient properties. We analyzed the main drawbacks of additive technologies and suggested the ways to overcome them. We described the problem in creating the equipment for hybrid technologies on the basis of a processing center and an industrial robot. We developed a concept for creating a Russian-made machine-tool for using hybrid technologies. Solutions are proposed for improving the structure of the material of parts.
Features of information modeling in the design of pre-school buildings in Russia
Authors: Minkinen Yury , Movsesova Liya
Published: June 2018

In the context of modern industrial base establishment on the new technology platform, the tendencies of IT-technologies penetration into building and structure design, construction and operation and transition to Building Information Model are getting more and more emphasized. This article focuses on BIM-modeling employment in the design of pre-school educational institution. Advantages of IT-modeling for buildings complying with modern ecological and safety demands are illustrated. Integration of data on building architecture, structure, interior decoration and utilities into integrated data model effectively saves time and allows making right decisions at all stages of object life cycle. The model allows making optimal decision accounting for such factors as weather conditions analysis, building shape, amount of people to be hold, periodicity of their stay, materials to be used, natural light level, utilities design etc.
Application of numerical integration methods to continuously variable transmission dynamics models
Authors: Stepan Orlov
Published: June 2018

The expansion of digital engineering technologies in the framework of the fourth industrial revolution relies on core technologies for mathematical modeling and computer simulation of physical processes. Time required for a computer simulation and the quality of numerical solutions are key factors that ultimately have impact on product quality and the amount of waste at product design stage. This paper is aimed on the reduction computer simulation time for continuously variable transmission (CVT) models. The modeling of the device as a set of deformable rigid bodies with numerous contact interactions is an extraordinary problem addressed in [1]. Model dynamics is described in terms of ordinary differential equations (ODE) of motion. The system of ODEs has about 3600 variables (generalized coordinates and speeds). Despite relatively low dimension of the model, computer simulation using traditional numerical integration methods takes long time to run. The reason for this is the stiffness of the ODE system. In this paper, we present the results of an investigation aimed on finding a numerical integration method appropriate for problems of this kind.
A digital method for correcting planned electric energy consumption as a step to the Energynet market
Authors: Russkov Oleg , Saradszhivili Sergei
Published: June 2018

Creating the modern high-tech industry should be viewed as a fusion of material and digital production and control methods. Industrial enterprises with uneven electric energy consumption, which have failed to adapt to the requirements of modern digital wholesale electricity market, have to spend significant money to pay for hourly deviations of electric energy, whose price constantly grows. A digital method for correcting planned electric energy consumption based on the theory of games is offered to reduce the costs of these enterprises, which have no possibility for regulating own load on a real time basis. The updating is carried out depending on hourly relations of prices on the wholesale electric energy market in order to exclude the risks of making unprofitable hourly transactions. An algorithm of the proposed method is provided and a predictive model developed on its basis is described and positive results of its testing on the basis of a metallurgical enterprise.
Building partnering in construction under conditions of a new information space
Authors: Shamara Yury , Smirnov Evgeny
Published: June 2018

The analysis of institutional and technological prerequisites is given in this article to implement the partnering mechanism in the Russian building with respect to the declaration of the state policy for formation of the digital economy and adoption of the relevant strategy and state program. Three elements of information environment which are under formation at present and that can form a technological basis for the wide application of the mechanism of partnering in the investment and building process are identified as the reference ones: technologies for building information modeling, information analysis systems which unite various construction aspects in a single complex, and banks of regulatory documents and standard forms of contracts for use by building participants. It was concluded that the conditions for transition from the conventional models for implementation of the investment and building process to the models based on the building participants’ partnership have been created in Russia.
Key performance indicators of high-tech enterprises
Authors: Verevka Tatyana
Published: June 2018

In the conditions of the transition to innovative development and digital economy, the unconditional priority is shifted to restoration and transformation of high-tech enterprises. The stability of their strategic developing greatly depends on the efficiency of their business activity and the system of the enterprise strategic management. This article defines the basic performance indicators of high-tech enterprises, the particular features of the system to evaluate the efficiency of strategic management of a high-tech enterprise: innovative, scientific-technological and intellectual potential. On the basis of the analysis of the methods widely used all over the world, we developed a system key performance indicators to evaluate the efficiency of high-tech enterprises, with consideration of particular features of operation and development of high-tech enterprises, to enable evaluating the efficiency of their business activities and management through analyzing the inter-related financial and non-financial performance indicators. The practical implementation of this system will make it possible for high-tech enterprises to form a data base for making strategic solutions to ensure competitive advantage of these enterprises and, as a consequence, facilitate their steady development.
Digital technologies and development of clusters in the light industry of the PRC
Authors: Zheng Yuan
Published: June 2018

China has demonstrated during the last thirty years the highest and the most stable GDP growth rate. It has helped the country become the biggest world exporter and significantly increase the social standard of living. However, the growth potential within the boundaries of engineering capability existing before has its limits and during the next 10-15 years the country will not be able to demonstrate the two-digit growth rate again. The same as the other industrially developed countries China has outlined the national prospects in the sphere of wide use of digital technologies. In this respect the development of textile sector of economics with more than 11 mln. people engaged is of a considerable interest. The article gives analysis to the new trends in industry development and offers new organizational models. It has been shown that in case of implementation of innovative development scenario and wide use of digital technologies the average annual growth rates in the period of 2018-2025 will be by 0.8 – 1.0 percentage points higher than in 2015-2016.
Knowledge of endoscopic ultrasound-delivered fiducial composition and dimension necessary when planning proton beam radiotherapy
Authors: Gleeson Ferga , Tryggestad Erik , Remmes Nicholas , Beltran Chris , Kruse Jon , Haddock Michael , Hallemeier Christopher , Storm Andrew , Levy Michael
Published: June 2018

Background and study aims Little consideration has been given to selection of endoscopic ultrasound-guided fiducials for proton radiotherapy and the resulting perturbations in the therapy dose and pattern. Our aim was to assess the impact of perturbations caused by six fiducials of different composition and dimensions in a phantom gel model.

Materials and methods The phantom was submerged in a water bath and irradiated with a uniform 10 cm × 10 cm field of 119.7 MeV monoenergetic spot scanning protons delivered through a 45 mm range shifter. The proton “Bragg Peak” was evaluated. 

Results Dose perturbations manifesting as dose reductions up to 30 % were observed. A carbon composite (1 × 5 mm) and gold (0.4 × 10 mm) fiducial with backload potential rather than dedicated EUS pre-loaded gold fiducial needles had the best performance in terms of minimizing the dose perturbation.

Conclusions Our data demonstrate that a carbon composite fiducial has a less untoward effect on proton therapy dose distribution than dedicated EUS pre-loaded gold fiducial needles. Such information is important to consider when selecting fiducials specifically for proton therapy.
Predictors for outcomes and readmission rates following double balloon enteroscopy: a tertiary care experience
Authors: Shelnut Danielle , Sims Omar , Zaibaq Jenine , Oh Hyejung , Venkata Krishna , Peter Shajan
Published: June 2018

Aim The objectives of this study are to examine clinical characteristics of patients undergoing anterograde and retrograde double balloon enteroscopy (DBE) and to assess factors predicting positive diagnostic yield, therapeutic yield, and readmission.

Methods We conducted a retrospective cohort study of patients (n = 420) who underwent DBE at a tertiary care center between 2012 and 2016 at a tertiary referral center. Measures of central tendency and frequency distributions were used for univariate analysis. Chi-square and t-test analyses were used to compare patient characteristics. Logistic regression was used to predict outcomes of interest.

Results Of patients included in the study, 59 % were male with a mean age of 61.49 (SD = 15.15) Altered anatomy was noted in 14 %, while 5 % and 13 % of patients had end stage renal disease (ESRD) and current use of anticoagulation, respectively. The most common indication for DBE was obscure gastrointestinal bleed (OGIB) (33 %). Forty-nine patients had obscure and overt gastrointestinal bleeding (GIB) and 22 % had occult GIB with iron deficiency. The cohort’s rate of positive diagnostic yield was 73 % and 35 % for therapeutic yield. The 30-day and 6-month readmission rates were both 11 %. A higher proportion of those readmitted were male (75 % vs 57 %, P = 0.027) and had longer procedural time (38.68 vs 46.57, P = 0.011). Likewise, occult GIB with iron deficiency anemia and iron deficiency alone (OR = 2.45, CI: 1.233 – 4.859, P = 0.011), inpatient status (OR 2.42, CI 1.344 – 4.346, P = 0.003), and longer procedural time (OR = 1.02, CI: 1.004 – 1.029, P = 0.008) were associated positively with readmission.

There were no statistically significant predictors of positive diagnostic yield, however procedural time (OR = 1.01, CI: 1.03 – 1.026; P = .0017) and older age (OR = 1.03, CI: 1.009 – 1.045, P = 0.003) were positively associated with therapeutic yield. Retrograde procedure (OR = 0.230, CI 0.125 – 0.422, P = 0.000) was negatively associated with therapeutic yield.

Conclusion DBE procedures have relevant efficacy for both diagnostic and therapeutic yield while evaluating small bowel disease. Readmission rates are low and more in those with GI bleed and iron deficiency with longer index procedural times.
Copper-Catalyzed Cross-Dehydrogenative-Coupling Reaction of N-Arylglycine Esters with Imides or Amides for Synthesis of α-Substituted α-Amino Acid Esters
Authors: Zhu Zhi-Qiang , Xie Zong-Bo , Le Zhang-Gao , Xiao Li-Jin , Guo Dong , Lu Yue
Published: June 2018

A simple and highly efficient cross-dehydrogenative-­coupling (CDC) reaction between N-aryl glycine esters and imides or amides by the catalysis of a copper salt without the requirement of ­peroxide agents is described. The novel reaction provides a facile ­approach for the synthesis of α-substituted α-amino acid esters through C–H/N–H oxidative cross-coupling. A possible mechanism for the CDC reaction by using copper as a catalyst and air as the terminal oxidant is also proposed. This synthetic approach has the advantages of good yields, simple operation and mild reaction conditions.
Skull Base Dural Thickness and Relationship to Demographic Features: A Postmortem Study and Literature Review
Authors: Fam Maged , Potash Andrea , Potash Martin , Robinson Robert , Karnell Lucy , O'Brien Erin , Greenlee Jeremy
Published: June 2018

Dural membrane is an important anatomic structure that surrounds and protects the entire central nervous system. Physical properties of the dura have many pathophysiological and therapeutic implications in cranial surgery, especially skull base disorders. The aim of this study is to investigate variation in skull base dural thickness and correlation with different demographic parameters. At the time of autopsy, the petrous apex dura with the underlying bone of 20 cadavers was harvested. Dural thickness was independently measured by two pathologists at the thinnest and thickest segments in the specimen. Correlational analyses were then performed to compare dural thickness with gender, age, neck circumference, height, weight, and body mass index (BMI). Mean, minimum, and maximum skull base dural thickness in our study was 0.36, 0.27, and 0.46 mm, respectively. Age demonstrated a negative correlation with dural thickness with significantly thinner dura in the older subjects, p = 0.01. There was a trend toward thinner dura in females that approached statistical significance, p = 0.06. No strong correlation could be found with body weight, height, neck circumference, or BMI. Our findings show a considerable intersubject and intrasubject variability in skull base dural thickness. Some demographic parameters also seem to impact dural thickness. Additional histological studies are needed for better understanding of the pathophysiological mechanisms pertaining to the tensile properties of the dural membrane.
Fracture of the Body's Hamate Bone: Open Reduction Internal Fixation by Double Approach—A Case Report
Authors: Salvador Marín Jorge , Brotons Baile Antonia , Cardona Vives Nuria , Vargas Prieto Jaime , Pérez Alba José , Martínez López José
Published: June 2018

Hamate fractures are rare. Their treatment depends on the displacement and type of fracture. We present the case and surgical technique of a 33-year-old male patient, who is a manual worker, with a displaced fracture of the body of the hamate bone associated with dislocation of the fourth and fifth metacarpal (MC) bones. The patient was operated on with a double palmar and dorsal approach directly over the hamate and the body hook, respectively, which was performed to improve the control reduction and avoid damaging the neighboring vascular and nerve structures. The open reduction internal fixation (ORIF) was performed by inserting mini-screws in a dorsal to palmar direction. Later, the dislocations were reduced and fixed with Kirschner wires between the fourth and fifth MC bases, and between the fourth MC base and the capitate bone. The patient was discharged 2.5 months after the fracture. The Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire outcome measure was 5 points at 6 months postsurgery.