bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYSIS OF THE LONG-TERM DYNAMICS OF THE GENERAL MORBIDITY AMONG RURAL RESIDENTS LIVING IN REGION SPECIALIZING IN HORTICULTURAL AND COTTON GROWING
Authors:   Peoples’ Friendship University, Moscow, KAMILOV OYBEK А. , KAMILOVA ROZA T. ,   nstitute of Sanitation of Hygiene and Occupational Diseases of the Ministry of Health of the Republic of Uzbekistan, NAVRUZOV ERNAZAR B. ,   nstitute of Sanitation of Hygiene and Occupational Diseases of the Ministry of Health of the Republic of Uzbekistan
Published: July 2022

Introduction. The trends study of morbidity allows to develop the strategies to eliminate inequalities in health between residents of rural areas, specialized on different sectors of agriculture. Aim. Comparative assessment and analysis of long-term dynamics of general morbidity among rural residents of horticultural and cotton-growing regions. Material and methods. We conducted analysis the data of statistical reporting of two five-year periods (2007-2011 and 2014-2018). Systematically evaluated database of Sanitation, Epidemiology and Health care Departments of Tashkent Province included the morbidity of adult residents living in Bostanlyk (horticultural) and Chinaz (cotton growing) regions. The analysis of the general morbidity was carried out according to ICD-10. Results and discussion. Dynamic obser- vations shown an increase of 6 leading classes of diseases (III, IV, IX, X, XI and XIV) in the cotton-growing region in 2014-2018 compared to 2007-2011 (78,3 ± 0,15 against 86,4 ± 0,12%; р < 0,001). The morbidity rates of the 14 classes of diseases out of 17 registered were almost 2 times higher in the cotton growing region than in the horticultural region (р < 0,05-0,001). Comparative analysis of the results in long-term dynamics show to a decrease in the general morbidity which is more pronounced in the horticultural region. The revealed correlation between the general morbidity in 15 classes of diseases with the volume of mineral fertilizers and pesticides used had a high level in the cotton-growing region. Conclusion. The results of this kind of research make it possible to timely identify trends in the spread of dis- eases, the reasons for the prevalence of certain classes of diseases and develop preventive measures. In our opinion the decrease of morbidity rate in the studied regions - is the result of the ongoing large-scale reforms in the health care system in the rural areas including a program to reduce the use of pesticides and fertilizers.
COMPREHENSIVE DIAGNOSIS OF PROSTATE CANCER
Authors:   Kazan State Medical Academy, NASRULLAYEV MAGOMED N. , NASRULLAYEV MARAT M. ,   Republican Clinical Oncology Dispensary, Kazan, KHASANOV MARAT Z. ,   Kazan State Medical Academy, NASRULLAYEV MURAD M. ,   Republican Clinical Oncology Dispensary, Kazan, FASSAKHOVA ADELINA А. ,   St. Petersburg State Medical University named after Academician I.P. Pavlov
Published: July 2022

Aim. The purpose of the study is to study the possibility of clinical, laboratory and instrumental diagnostics in the combination in the diagnosis of prostate cancer. Material and methods. 147 patients were examined, the middle age of which was 69.5 ± 6.7 years. All patients underwent examination: identification of the level of prostate-specific antigen (PSA) in blood serum, ultrasound transabdominal and transrectal examination in B mode, followed by the use of color Doppler mapping of blood flow, 3-dimensional Dopplerography, elastography and intravenous contrast enhancement. All patients underwent multifocal transrectal biopsy under ultrasound control followed by morphological examination of the obtained material. Results and discussion. The digital rectal examination found an increase of the prostate’s size at 115 patients, increase of the prostate’s density – at 69 patient, the high density’s existence of separate nodes - at 59 patients. The median level of prostate-specific antigen in the blood serum of the surveyed patients was 16,5±6,7 ng / ml. Under transrectal ultrasound at 88 patients the hypoechogenicity center, at 34 – isoechogenicity and at the 22 th center – the mixed echogenic was revealed. We identified 111 patients with abnormal vascularity in disintegration and deformation of vascular pattern. Hyperintensive contrast in 59.0% of cases, rapid accumulation of the contrast agent in 56.0% and rapid leaching of the drug in 59.0% of cases were characteristic of prostate cancer. Comparison of data obtained at transrectal ultrasound with indicators of the Gleeson’s scale was carried out. It was established that hypoechogenic focus is more common in the total score 5-7, and less than 5 points, isoechogenic tumor often with a score 5-7. The pathological vascularization was more often diagnosed in the group of patients with a score 5-7. Conclusion. The use of clinical laboratory and modern methods of ultrasound examination in a complex allows to increase the effectiveness of prostate cancer diagnosis, which undoubtedly contributes to the choice of rational treatment tactics.
INHIBITION OF SODIUM GLUCOSE TRANSPORT PROTEIN 2: CLINICAL AND PHARMACOLOGICAL EFFECTS IN CHRONIC HEART FAILURE
Authors:   Kazan State Medical University, GALYAUTDINOV GENSHAT S. , ZHIDYAEVSKIJ ALEXANDER G. ,   Kazan State Medical University, NESTERINA MARIA K. ,   Kazan State Medical University, MINNEGALIMOVA KARINA R. ,   Kazan State Medical University
Published: July 2022

Introduction. This article provides information of sodium-glucose co-transporter-2. Aim. The aim of the study was to review the current information on the positive effect of drugs from the sodium-glucose co-transporter-2 on the cardiovascular system of patients with chronic heart failure. Material and methods. A review of current published studies of sodium-glucose co-transporter-2 is provided. Results and discussion. In 2015, for the first time, there was a mention of the positive effect of sodium-glucose co-transporter-2 on the cardiovascular system of patients with type 2 diabetes mellitus. There was a decrease in the risk of death from cardiovascular diseases, non-fatal myocardial infarction, acute cerebrovascular accident, as well as a decrease in the frequency of hospitalizations for exacerbation of chronic heart failure. In 2020, information was obtained on the isolated effect of this group on chronic heart failure, regardless of the presence of type 2 diabetes. When studying the drugs, it was found that their cardioprotective effect is due to a decrease in blood pressure by increasing osmotic diuresis, partial suppression of the activity of the renin- angiotensin-aldosterone system due to an increase in sodium concentration in the area of the dense spot of the distal convoluted tubule, increased oxygen delivery to the heart muscle by stimulating erythropoiesis. Conclusion. It is reasonable to use drugs that belong to the group of inhibitors of sodium-glucose co-transporter-2 in clinical practice for the treatment of patients with chronic heart failure, regardless of whether they have type 2 diabetes mellitus.
MATHEMATICAL MODELING OF THE VEHICLE STABILITY CONTROL OF THE VEHICLE
Authors: Aleksandrov Yevhen , Klymenko Valerii , Leontiev Dmytro , Ternovyi Mykyta
Published: July 2022

The paper reviews the scientific and technical literature on the development of electronic stability systems with brake force distribution, which led to the conclusion that for all-terrain wheeled vehicles such systems should be built using inertial navigation sensors - gyroscopes and accelerators. The proposed functional scheme of the stability system with brake force distribution is built using the principles of platformless inertial systems, in which the orientation of the car body relative to the axes of the inertial coordinate system is carried out by calculating in the onboard digital computer quaternion in contrast to Euler angles can be calculated with the required degree of accuracy using a fairly simple algorithm. Algorithms for estimating the current parameters of perturbed motion of the wheel body in the process of its urgent braking, namely, the angle of deviation of the elongated axis of the body from a given direction, angular velocity and lateral displacement of the center of gravity relative to a given trajectory. On the basis of the current estimation of the listed parameters the algorithm of stabilization of the case of the wheeled car in the mode of its urgent braking is formed.
JUSTIFICATION AND CHOICE OF ENERGY FACILITIES FOR AGGREGATION OF AGRICULTURAL MACHINES
Authors: Zubko Vladyslav
Published: July 2022

The paper studies and analyzes the technological parameters of modern running systems of machine units and the environment for their use in accordance with modern conditions. As a result of the experiments, the dependences of the rolling resistance coefficients, adhesion and towing for wheeled propellers, caterpillar on rubber and caterpillar on steel, depending on hardness and background, were obtained. So, for power vehicles with a rubber caterpillar, the functions of these values, depending on the hardness of the soil in a layer of 0-10 cm, will be as follows: f = -0,015Т2 + 0,169Т + 0,472, µ = -0,001Т3 + 0,015Т2 - 0,078Т + 0,204, δ =0,033 ехр(7,154р) + 0,792.

The obtained data have a high approximation reliability and are used in the operation of the algorithm of the controlled system
PRINCIPLES OF RATIONAL AGGREGATION OF TRACTOR SELF-PROPELLED CHASSIS
Authors: Podryhalo Mykhailo , Krasnokutskiy Volodymyr , Shevtsov Vadym
Published: July 2022

The article considers the optimal location of the mounted machine on the frame of the self-propelled chassis for the rational use of traction and coupling properties of the machine-tractor unit. The criteria of their optimal aggregation are determined taking into account the conditions of fulfillment of the corresponding agrotechnical requirements. Recommendations for checking the possibility of aggregating it with a specific attachment are provided. Theoretically and experimentally it is proved that the tractor of classical layout is inferior to self-propelled tractor chassis of similar weight and power in traction, fuel economy, passability, controllability, maneuverability, stability and a number of other parameters and has no possibility of axle suspension. Different layout schemes, redistribution of normal reactions along the axes and the specifics of the force action distinguish the traction dynamics of TSSH from the traction dynamics of the tractor
"Smart" electric devices for household switch box with remote control: market overview, directions for further improvement and research
Authors: Sidak Vitalii , Panteliat Mykhailo
Published: July 2022

“Smart home” systems are becoming increasingly common in modern society. There are a significant number of "smart" electrical devices on the market: relay switches with electromagnetic or solid-state relays; as well as circuit breakers. The purpose of the work is a comparative analysis of the principles of operation, technical characteristics, advantages and disadvantages of "smart" electric devices for household switch box with remote control that are present at the modern markets and the formulation of proposals to eliminate the identified shortcomings by conducting research and development work. From a generalized comparison, this is concluded that the technical solutions of "smart" devices based on relays are still generally inferior to their "brothers"-circuit breakers, mainly in types of protection. It is proposed to eliminate this significant drawback by using a power supply (AC-DC converter) that supports the appropriate types of protection.
Quadrature phase shifter for the measurement systems of testing of electrical insulation
Authors: Kostiukov Ivan
Published: July 2022

Quadrature phase shifters are widely used in practice of development of measurement systems intended for the measurements of dielectric dissipation factor and electrical capacitance. This article presents the examples of implementation of phase shifters intended to obtain the value of phase shift equal to 90º for the applying in measurement systems of monitoring and diagnosing the technical condition of electrical insulation. The developed solutions are based on applying of the analog signal multiplier implemented in the AD633 integrated circuit. The required value of phase shift is provided by adding a pre-shifted at a certain angle input harmonic signal to a signal with the reduced amplitude and the opposite initial phase. The article is also focused on the development of schematic solutions which can be used in order to remove the undesirable for many practical applications discrepancy between the amplitudes of the input and the output signals. This alignment of amplitudes is provided by the detection of their average rectified values with subsequent multiplication of their ratio by the shifted at 90º signal with the reduced amplitude. The designed schematic solutions imply the applying of analog circuits which contain the input phase shifter, low pass filter, voltage summing amplifier, two detectors of average rectified values, three analog multipliers and one voltage divider.
EVOLUTION OF FORM IN AVANTGARDE CONTEMPORARY ARCHITECTURE IN THE CONTEXT OF PUBLIC PARTICIPATION PROCESSES
Authors:   Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Poland Wydział Architektury Katedra Architektury Współczesnej, Teorii i Metodologii Projektowania, Bizio Krzysztof
Published: July 2022

The subject of this paper is an analysis of the impact of public participation on the form of contemporary architecture. A division into three basic stylistic-temporal trajectories was made, distinguished based on design methodology that includes participation: late Modernism, Postmodernism, and participative architecture of the early twenty-first century. Based on an analysis of theoretical texts and selected structures, distinctive features of a given period were identified. The study resulted in an identification of major tendencies that document changes in architectural forms stemming from a diverse range of design methodologies that feature participation.
THE BEGINNINGS OF MUSEUM ARCHITECTURE IN THE UNITED STATES
Authors:   Politechnika Łódzka, Łódź, Poland Instytut Architektury i Urbanistyki Zakład Rysunku, Malarstwa i Rzeźby, Pabich Marek
Published: July 2022

Contrary to Europe, where museums were created from transformed collections, in America the first museums were founded on the basis of scientific institutions. Only in the second half of the nineteenth century, museums are formed based on private collections. Objects were erected to house the collections, which for a long time, almost until the middle of the 20th century, stylistically referred to the architecture of ancient Greece. From the mid-nineteenth century, museums began to be built, for which architects looked for inspiration in later styles. And although neo-gothic, neorenaissance and neo-baroque objects appeared, the Greek Revival dominated museum architecture in the United States, created by graduates of the Parisian École des Beaux-Arts.
HOUSING SPACE VALUATION AGAINST THE BACKGROUND OF POST-SECOND-WORLD-WAR ECONOMIC AND SOCIAL PROCESSES
Authors:   Zachodniopomorski Uniwersytet Technologiczny w Szczecinie, Poland Wydział Architektury Katedra Mieszkalnictwa i Podstaw Techniczno-Ekologicznych Architektury, Wojtkun Grzegorz
Published: July 2022

In the period of the SARS-CoV-2 pandemic and, most importantly, of threat to world peace, humanitarian and rational multi-family housing could contribute to stabilizing the economic and social situation. This appears particularly essential in a situation of the fast-approaching land shortage for housing in cities. In this paper, the author discusses the size of usable apartment space and the quality of functional and spatial layouts understood in terms of their physical reach. The economic aspect associated with the amount of construction material used was noted. The above could contribute to the discussion on the future development trajectory of multi-family housing.
MULTILEVEL INTEGRATION OF DESIGN AND THE QUALITY OF LIFE IN URBAN SPACE ISSUE
Authors:   Zachodniopomorski Uniwersytet Technologiczny w Szczecinie Wydział Architektury Katedra Projektowania Architektonicznego, Barełkowski Robert , Rosolski Sławomir ,   Politechnika Poznańska Wydział Architektury Instytut Architektury, Urbanistyki i Ochrony Dziedzictwa
Published: July 2022

The essence of urban design is the transformation of the environment in a way that maximizes the quality of human life. The tools to achieve this goal must cope with the complexity of natural and urbanized spaces, and designers use them to anticipate future environmental states. The article presents theoretical considerations, supplemented by the practical implementation of the area in the Swarzędz community, on the relationship between the organization of urban design in the context of multi-level integration (planning, design) and the emergence of a high-quality urban environment. This process requires controlling many parallel threads between which there are dynamic changes in the relationship - the holarchy.
Micro, Small, and Medium Enterprises (MSMEs) Rebranding
Authors: Sholihah Dienni Ruhjatini , Fadlillah Alnisa Min , Mira Rahmi
Published: July 2022

Micro, Small, and Medium Enterprises (MSMEs) have great potential to drive the country's economy, especially in developing countries like Indonesia.  However, many views often reveal that MSMEs have low competitiveness. So, they are not considered a sustainable business and are not managed professionally, both in finance, marketing, and human resources. Therefore, currently, MSMEs are labeled as difficult to develop.

This community service aims to change the paradigm of MSMEs through small steps to rebrand our MSME Partners. This activity is performed by providing assistance to the MSME participants that are related to 3 essential aspects: finance, marketing, and human resources. The assistance method in this program is carried out in some steps. The first step is carrying out observation since the location survey was carried out. Then, the implementation is carried out in these methods: lectures of theoretical presentations, assignments, practice trials, and finally, the designing of the rebranding model. With this program, the partners are expected to be able to improve and become MSMEs that are more competitive. They must have a positive image, so they can viewed as a professional business unit and generate significant profits.
The Role of Psychoeducation in Raising Awareness About Gifted Children Towards Teachers
Authors: Medellu Gita Irianda Rizkyani , Issom Fitri Lestari , Sy Vinna Ramadhany
Published: July 2022

Certain phenomena have been found within our target for Community Service activity of the Faculty of Psychology Education, the State University of Jakarta, which is taking place at SMPN 139, Jakarta. The issue that arose from the target school is despite being an inclusive school, the understanding among the teachers still lacks regarding particular special needs of students. The stigma said that Gifted children were considered an advantage; they thought Gifted children didn't need special treatment and managing adaptable programs to facilitate Gifted children. In fact, special need children even Gifted one still need to optimize their capacities with the proper program that could be managed by the school. In an effort to increase this awareness, teachers will be involved this community service, which includes several activities. Our program mainly focused on Psychoeducation in the form of webinars through material presentations, video, discussion. The result of the community Service program at SMPN 139 Jakarta showed the significant differences between the results before giving psychoeducation program, and after the program, it means there was an effect of providing Psychoeducation about gifted students to increase the awareness of teachers at SMPN 139 East Jakarta.
Fostering the Learning Outcomes Achievement of Class X High School Students on the Protist Concept Using The Visuospatial Wimba Learning Model
Authors: Khastini Rida Oktorida , Rifqiawati Ika , Alawiyah Tuti
Published: July 2022

The study was conducted to determine the influence of the visuospatial Wimba learning model for the student learning outcome of class X on the protist concept. The method used in this research was quasi-experiment with the design of the posttest only control group design. The population of this research was all X MIPA of publi madrasah aliya in Kota Cilegon. The sample of this research was X MIPA 1 as the experiment class and X MIPA 2 as control class carried out by simple random sampling. The data collection techniques used were a multiple-choice test and a 3D media assessment. The results showed in cognitive and psychomotor aspects for the experimental class were 84 and 85.14, while in the control class was 63 and 73.04. The result of the  hypothesis test analysis showed the significant value of learning outcomes on cognitive and psychomotor aspects was  0,00 and 0,03 respectively which is < 0,05. Thus it can be concluded that the visuospatial Wimba learning affects student learning outcomes.

 
Integration Pattern of Biology and Science Learning Based on Islamic Science
Authors: Jamaludin Didi Nur , Budhi Henry Setya , Choir Muhammad Charis Mazidatul , Yusman Muhammad
Published: July 2022

The scientific integration paradigm has contributed to education. This study aims to determine the pattern of integration of Biology and science learning based on the integration of Islamic science, through field studies. The research was conducted using semi-structured interviews about experiences in integrating biology and science learning with Islamic sciences. The pattern of integration of Biology and Science based on the integration of Islamic science includes aspects of affective and cognitive. Attitudes have a pattern of development such as belief, admiration, humility, gratitude, motivation and self-awareness. Knowledge has a pattern of connecting scientific knowledge with Islamic knowledge both sourced from the Qur'an and Hadith as well as other Islamic knowledge. Biology and science learning have values that can be developed for the formation of students' character.

 

 
Early-Career Sports Medicine Surgeons Perform a Large Volume of Non-Sports Medicine Procedures
Authors: Inclan Paul M. , Wright Rick W. , Smith Matthew V. , Brophy Robert H.
Published: July 2022

Background:

The purpose of this study was to utilize the American Board of Orthopaedic Surgery (ABOS) Part-II Case List database to (1) define the practice patterns of sports medicine-trained ABOS Part- II Oral Examination Candidates and (2) describe the frequency and practice patterns of individuals who are dual fellowship-trained sports medicine candidates.

Methods:

The ABOS Part-II Case List database was utilized to define all cases submitted by 3,298 applicants indicating completion of a sports medicine fellowship between January 1, 2003, and January 1, 2020. Cases were classified by subspecialty category and case type. The frequency and practice patterns of candidates pursuing additional fellowship training (i.e., “dual fellowship-trained”) were recorded. Descriptive statistical methods were used to describe the annual and overall procedure volume and candidate case mix. Trends in the relative frequency of cases performed and fellowship training patterns were determined using linear regression analysis.

Results:

On average, sports medicine-trained candidates submitted 100.6 cases for review during the 6-month case collection period: 59.0 (58.6%) sports medicine/arthroscopy cases, 29.3 (29.1%) trauma/general cases, 4.5 (4.5%) adult reconstruction cases, and 7.8 (7.8%) “other” cases per candidate. Although candidates performed fewer total (r2 = 0.84, p < 0.001) and sports medicine/arthroscopy (r2 = 0.85, p < 0.001) cases over the study period, the proportion of sports medicine/arthroscopy cases did not change over the study period (p = 0.18). Dual fellowship training was indicated by 333 individuals (10.1%). The number of dual fellowship-trained candidates pursuing additional fellowship training in pediatrics and adult reconstruction increased over the study period, and the number of dual fellowship-trained candidates pursuing additional fellowship training in trauma decreased over the study period.

Conclusions:

Early-career sports medicine candidates are likely to perform >40% of cases outside of the sports medicine subspecialty. Sports medicine trainees are increasingly likely to pursue a second fellowship in pediatrics or adult reconstruction.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Perancangan Sistem Informasi Buku Penghubung Menggunakan Model User Centered Design (UCD) Berbasis Web
Authors: Doni Wicaksono  , Yoyok Seby Dwanoko  , Wiji Setiyaningsih
Published: July 2022

Abstrak. Keberadaan teknologi informasi dalam bidang pendidikan memudahkan  akses informasi secara cepat , tepat dan dapat diakses dimana saja salah satunya yaitu sistem informasi buku penghubung. TK Saint Joseph Montessori School Malang menggunakan buku penghubung sebagai penjembatan komunikasi orang tua dengan guru. Penggunaan buku penghubung secara manual memiliki kelemahan yang belum teratasi dengan baik, orang tua siswa tidak membaca buku penghubung dikarenakan anak kelupaan menyampaikan, siswa terkadang lupa membawa buku penghubung sehingga informasi tidak bisa tertuliskan dengan rutin dan jelas, sedangkan guru membutuhkan waktu yang lama dalam menuliskan buku penghubung karena harus menulis satu persatu dan berulang. Hal tersebut tentu saja menjadikan kegiatan tidak efektif dan efisien. Pembuatan sistem informasi buku penghubung berbasis web menggunakan model pengembangan UCD (User Centered Design) bertujuan untuk membangun sistem yang menyesuaikan kebutuhan dengan pengguna sehingga memudahkan komunikasi antara guru dan orang tua dalam melihat perkembangan anak di sekolah . Dari hasil penelitian yang dilakukan pembuatan sistem buku penguhubung menggunakan model pengembangan UCD (User Centered Design) dapat menghasilkan sistem yang sesuai dengan kebutuhan pengguna , berjalan sesuai fungsi yang telah diuji dengan blackbox testing dan sistem mendapatkan hasil  User Acceptance Test (UAT) dengan rata – rata 84.39% dari 3 aspek pengujian sehingga dapat disimpulkan  mempermudah komunikasi antara guru dan orang tua, dengan adanya sistem informasi buku penghubung proses pencatatan menjadi lebih cepat ketimbang menggunakan manual dengan buku serta lebih menghemat kertas (paperless).

Kata Kunci: buku penghubung; user centered design; komunikasi
The Use of Peers in Assessment for Learning: A Case Study of Trainee Teachers at Bindura University of Science Education (BUSE), Zimbabwe
Authors: Mudavanhu Young , Mutseekwa Christopher
Published: July 2022

The study was an exploration of trainee teachers’ understanding, perceptions of, and confidence in the use of peers in assessment for learning (AfL) at Bindura University of Science Education, Zimbabwe. Trainee teachers were enrolled in a programme that used a blended model of teaching and learning between February and June 2021. Trainees participated in online seminars and peer assessment in a course on curriculum development and completed questionnaire eliciting their attitudes toward peer assessment. A mixed-methods approach using both quantitative and qualitative methodologies was adopted. Quantitative data were analysed using descriptive statistics, mean item scores and the summated scores for the three constructs of confidence, benefits of and threats to peer assessment. Open-ended items were analysed qualitatively and emerging themes were reported. Summated scores of 4, meant trainees had positive attitudes toward peer assessment and believed in numerous benefits of using peer assessment. A summated mean score of 3 for threats to peer assessment meant trainee teachers had neutral views to the construct. Conflicting messages were evident. The same trainees who believed that peer assessment was useful still doubted sincerity of peers and preferred teacher assessment. Further research, using a larger population and sample and interviews to probe doubts in peer assessment, is recommended.
Diferencias de personalidad entre adolescentes infractores en Brasil y España evaluadas con el Jesness Inventory Revised
Authors: Wenger Amengual Lorena , Santos Costa Rafaelle Carolynne , Vilela Komatsu André , Rezende Bazon Marina , Andres-Pueyo Antonio
Published: July 2022

En delincuencia juvenil, algunos aspectos de la personalidad tienen un peso importante en la probabilidad de realizar conductas antisociales. Por esto, integrarlos al trabajo con esta población permite hacer las intervenciones más sensibles a las características de los jóvenes y, por ello, más efectivas. Como las estructuras de muchos sistemas de atención de la delincuencia juvenil tienen objetivos socioeducativos semejantes, los estudios transculturales/comparativos son pertinentes para explorar este problema. El objetivo de este estudio fue comparar grupos de adolescentes de Brasil y España, infractores y no infractores, con respecto a aspectos de personalidad. La muestra estuvo compuesta por 210 adolescentes varones con una edad media de 17.7 años. Estos jóvenes respondieron al Jesness Inventory – Revised (JI-R), una herramienta que mide el funcionamiento psicológico en el contexto de justicia juvenil. Las puntuaciones directas en el JI-R fueron comparadas por análisis de varianza (ANOVA) y el tamaño de efecto fue calculado con la d de Cohen. Los resultados muestran que, entre los grupos de infractores, la muestra de adolescentes brasileños presenta niveles más elevados en Valores Subculturales y Ansiedad Social. Como se hipotetizaba, los grupos de infractores no son tan distintos entre sí, en especial a lo que se refiere a la orientación antisocial, lo que suma evidencia a que adolescentes que se desarrollan en culturas distintas comparten variables de personalidad asociadas al comportamiento delictivo
Seni Kethek Ogleng Pacitan dan Seni Kethek Ogleng Wonogiri: Kajian Bandingan
Authors: Hendriyanto Agoes , Mustofa Arif , Sutopo Bakti
Published: July 2022

Tujuan utama penelitian ini adalah mendeskripsikan keberadaan seni Kethek Ogleng di Kabupaten Pacitan dan di Kabupaten Wonogiri sehingga seni tersebut dapat dipahami secara komprehensif. Permasalahan utama penelitian ini adalah persamaan dan perbedaan aspek-aspek yang terdapat dalam seni Kethek Ogleng di Kabupaten Pacitan maupun yang ada di Kabupaten Wonogiri. Aspek itu antara lain  aspek sejarah, gerakan, tata busana-tata rias, dan fungsi. Penelitian ini termasuk penelitian  kualitatif.  Hasil penelitian sebagai berikut; pertama, terdapat keterpengaruhan seni Kethek Ogleng di Wonogiri dengan yang ada di Pacitan. Penyebabnya seni Kethek Ogleng di Pacitan muncul lebih dahulu dibanding dengan yang ada di Wonogiri. Kedua, terdapat perbedaan pembagian gerak dan juga iringan antara seni Kethek Ogleng di Kabupaten Pacitan dengan di Kabupaten Wonogiri. Ketiga, segi tata busana dan tata rias secara garis besar terdapat kesamaan antara seni Kethek Ogleng di Kabupaten Pacitan dengan yang ada di Kabupaten Wonogiri, yakni sama-sama menonjolkan tokoh tari yang merepresentasikan Kethek. Namun dari segi tersebut terdapat perbedaan antara lain terletak pada pemakaian kain poleng dan tata rias wajah. Keempat, terdapat  kesamaan antardua seni tersebut terletak pada fungsi. Baik seni Kethek Ogleng di Kabupaten Pacitan maupun di Wonogiri mempunyai fungsi sebagai pertujukan, menghibur, kebanggan masyarakat, dan juga sebagai sarana untuk mendidik generasi penerus.
Tahap Perkembangan dan Pola Asuh Anak Usia 9-12 Tahun dalam Persepektif Islam
Authors: Perdiansyah Perdiansyah , Widodo Slamet
Published: July 2022

Islam is a very perfect religion. All aspects of life have been arranged in great detail. No exception to the stage of development and parenting of children aged 9-12 years. But unfortunately part of Muslims today do not know that Islam has set out in such detail the stages of development and parenting of children aged 9-12 years. Therefore, it is necessary to research on the stages of development and parenting of children aged 9-12 years in an Islamic perspective. It aims to provide reference material or reading material to parents and educators to educate their children Islamically. This study uses the literature review method by collecting data from various main sources originating from the Alquran, Alhadis, articles, and other relevant secondary sources. The results of this study are in the form of material or reading material that can be used as a reference for educating children Islamically.
Penerapan Model Pembelajaran Kooperatif Tipe Snowball Throwing Untuk Meningkatkan Aktivitas Belajar Siswa Kelas IV SD Dwijendra Denpasar
Authors: Ana Teda Oktavianus
Published: July 2022

Penelitian ini bertujuan untuk mengetahui penerapan model pembelajaran kooperatif tipe snowball throwing dalam meningkatkan aktivitas belajar siswa kelas IV SD Dwijendra Denpasar. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK) yang terdiri dari 2 siklus. Setiap siklus terdiri dari tahap perencanaan, pelaksanaan tindakan, pengamatan atau evaluasi dan refleksi. Subyek penelitian ini adalah siswa kelas IV SD Dwijendra Denpasar dengan jumlah siswa 25 orang yang terdiri dari 8 orang siswa laki-laki dan 17 orang siswa perempuan. Data mengenai aktivitas belajar diperoleh menggunakan metode observasi dengan instrument yang berbentuk lembar observasi. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik analisis deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa melalui penerapan model pembelajaran kooperatif tipe Snowball Throwing pada siswa kelas IV SD Dwijendra Denpasar dapat meningkatkan aktivitas belajar siswa. Hal ini dapat dilihat dari persentase rata-rata aktivitas belajar yang diperoleh yaitu pada refleksi awal (prasiklus) rata-rata aktivitas belajar hanya mencapai 53,73%. Berdasarkan hasil penelitian dari siklus I sampai pada siklus ke II, aktivitas belajar berupa persentase rata-rata pada siklus I yaitu 65,27% yang berada pada kategori cukup aktif. Setelah diadakan perbaikan tindakan pada siklus II, rata-rata aktivitas belajar siswa semakin meningkat menjadi 80,73% berada pada ketegori aktif sehingga terjadinya peningkatan persentase rata-rata aktivitas belajar siswa dari siklus I ke siklus II sebesar 15,46%. Berdasarakan hasil analisis yang telah dilaksanakan disimpulkan bahwa model pembelajaran kooperatif tipe snowball throwing dapat meningkatkan aktivitas belajar siswa kelas IV SD Dwijendra Denpasar.
El paisaje agrario en la montaña mediterránea semiárida: la evolución de los regadíos históricos de la Sierra de la Contraviesa
Authors: Camacho-Castillo Jesús , Porcel-Rodríguez Laura , Jiménez-Olivencia Yolanda
Published: July 2022

Los regadíos históricos han sido una invariante en los paisajes de una montaña mediterránea semiárida como la Sierra de la Contraviesa (sureste de España). Estos espacios regados han contribuido, pese a su exigua extensión, a diversificar el mosaico agrario serrano y la economía local, presentando unas constantes paisajísticas relativamente estables durante siglos. Pese a todo, desde 1950, la marginalidad socioeconómica de este ámbito dentro de la actual dinámica territorial de la región, ha desencadenado profundos cambios. Este trabajo tiene por objeto interpretar en clave paisajística la evolución histórica y multiplicidad de funciones de estos sistemas y su papel actual en el mosaico de los agrosistemas presentes en el macizo. Para ello, se profundiza, en primer lugar, en las bases físicas que sustentan el regadío y en el proceso de conformación histórico-geográfica (ss. IV-XX) de estas estructuras heredadas. En segundo lugar, y partiendo de la cartografía histórica catastral, se realiza un análisis diacrónico de su extensión y configuración en los principales perímetros de regadío para los últimos 70 años. Los resultados obtenidos revelan cómo la reciente desarticulación del modelo de gestión tradicional compromete la continuidad de estos sistemas y de sus diversos valores asociados, determinando un progresivo empobrecimiento y homogenización paisajística.
Los dibujos de Richard Ford sobre el paisaje de Gibraltar (1830–1833)
Authors: Gámiz Gordo Antonio , Pardo González Juan Carlos
Published: July 2022

Durante sus viajes por España en 1830–1833, Richard Ford realizó cientos de dibujos de los lugares visitados, cuyo conjunto no se ha conocido hasta una exposición en 2014. En esta investigación se analizan por primera vez sus dibujos sobre el entorno geográfico de Gibraltar, en gran parte inéditos. Primero se presentan sus apuntes del relieve costero tomados en barco desde el mar, después visiones lejanas del Estrecho desde Gaucín, panorámicas de la bahía de Algeciras, vistas del Peñón y sus fortificaciones, más bocetos de vegetación y personajes. Los dibujos no tenían pretensiones artísticas ni comerciales, pero aportan una rigurosa descripción que se complementa con los textos que el propio autor publicó en su famoso libro A Handbook for Travellers in Spain (1845). Como referencia comparativa también se han considerado imágenes y textos sobre Gibraltar de otros autores diversos. Las precisas observaciones de Ford, previas a la aparición de la fotografía, tienen un excepcional valor documental como testimonio gráfico y literario que facilita la comprensión de este singular territorio y su paisaje en el siglo XIX.
Regularidad global y variabilidad local de los patrones espacio temporales de la COVID 19 en Aragón (España)
Authors: Escolano-Utrilla Severino , Salvador-Oliván Jose Antonio
Published: July 2022

Con datos de casos confirmados de COVID 19 en Aragón (España), agregados en 123 Zonas Básicas de Salud durante 50 semanas consecutivas, se han identificado, medido y caracterizado los patrones espaciotemporales de la pandemia. Para este fin se han utilizado medidas de autocorrelación espacial y temporal de los datos obtenidas mediante la aplicación de procedimientos de estadística espacial (índices I global e Ii local de Moran). La incidencia espacial y temporal de la COVID 19 en Aragón no ha sido ni homogénea ni aleatoria, pues muestra cierta regularidad global y notable variabilidad local. Este modelo se puede explicar por un proceso de difusión espacial modificado por contagios a larga distancia y restringido por las medidas de control de la pandemia. La información obtenida es muy útil para tomar decisiones en materia de salud pública, relativas a la organización de los recursos sanitarios y a las determinaciones para la prevención y control de la pandemia.
Outbreak of vancomycin-resistant Enterococcus faecium starting among patients admitted to a surgical unit in a Swedish county
Authors: Gideskog Maria , Welander Jenny , Hällgren Anita
Published: July 2022

Background
Vancomycin-resistant Enterococcus faecium (VRE) is a nosocomial pathogen that causes infection mainly in patients with critical illnesses in intensive care units, severe underlying diseases or weakened immune systems. Intensive pretreatment with antibiotics and the use of urinary catheters also constitute a risk. Due to its hardy nature, the bacterium can survive for long periods in a hospital environment. The aim of this study was to describe the investigation of a sudden increase in VRE cases admitted to the surgical unit at Vrinnevi Hospital in Norrköping, Sweden, and the control measures taken.
Methods
Faecal cultures from patients admitted to the surgical unit were obtained, and environmental cultures were collected from different locations in patient rooms and medical devices. In addition, screening samples were obtained from units with high-risk patients in Östergötland County. Isolates identified as E. faecium were subjected to antibiotic susceptibility testing. Vancomycin-resistant isolates PCR-positive for the vanA/vanB gene were further analysed with whole-genome sequencing (WGS).
Results
A total of 35 VRE isolates were found (22 from patients and 13 from the environment). The WGS identified three outbreak clusters, sequence type (ST) 203, ST 1839 and ST 80, and one unique clone (ST 612). The ST 203 clone predominated among VRE cases admitted to the surgical unit.
Conclusions
With prompt infection control measures, the VRE outbreak was over after approximately four months. To prevent further outbreaks of VRE, active screening, antibiotic stewardship, improved cleaning and hand hygiene, and restriction of multiple-bed rooms is essential.
The Stat3 inhibitor F0648-0027 is a potential therapeutic against rheumatoid arthritis
Authors: Kaneko Yosuke , Ozawa Shin-ichiro , Sato Yuiko , Kobayashi Tami , Matsumoto Tatsuaki , Miyamoto Kana , Kobayashi Shu , Harato Kengo , Hirono Shuichi , Matsumoto Morio , Nakamura Masaya , Niki Yasuo , Miyamoto Takeshi
Published: July 2022

Background
Rheumatoid arthritis (RA) is a disease characterized by chronic joint inflammation, pain and joint destruction, leading to alteration in activities of daily living, yet pathological mechanisms underlying the condition are not fully clarified. To date, various therapeutic agents have been developed as RA therapy including DMARDs and/or biological agents that target inflammatory cytokines or inhibit JAK. Here we asked whether inhibiting signal transducer and activator of transcription 3 (Stat3) activity would antagonize RA.
Methods
Stat3 forms dimers when activated and undergoes nuclear translocalization; thus we screened approximately 4.9 million small compounds as potential blockers of protein-protein interactions required for Stat3 dimerization using in silico screening. We then tested candidate Stat3-inhibiting activity in vitro by analyzing expression of IL-6, a Stat3 target, in compound-treated fibroblasts. We also analyzed expression of RANKL, a cytokine essential for osteoclastogenesis, in vitro. We then evaluated anti-arthritis effects of candidate compounds in vivo in collagen-induced arthritis model mice. Effects of the candidate compounds on inhibiting Stat3 phosphorylation and nuclear localization following IL-6 stimulation of fibroblasts were analyzed by an immune histocochemical analysis as well as western blotting.
Results
We identified 15 as strong candidates as potential blockers of protein-protein interactions required for Stat3 dimerization using in silico screening from approximately 4.9 million small compounds. Four of the 15 significantly inhibited IL-6 as well as RANKL expression induced by IL-6. One compound, F0648-0027, significantly inhibited arthritis development without apparent adverse effects. F0648-0027 also significantly blocked Stat3 phosphorylation and nuclear localization following IL-6 stimulation of fibroblasts.
Conclusions
These data suggest that Stat3 is a target for RA, and that F0648-0027 could serve as a therapeutic reagent against the condition.
PRDM15 interacts with DNA-PK-Ku complex to promote radioresistance in rectal cancer by facilitating DNA damage repair
Authors: Yang Yanyong , Yu Yue , liu tingting , Yu Guanyu , Wang Hang , Du Zhipeng , Chen Yuanyuan , Yang Nan , Cao Kun , Liu Chunlei , Wan Zhijie , Shen Hui , Gao Fu , Zhang Wei
Published: July 2022

Background
Neoadjuvant chemoradiotherapy is a standard treatment for locally advanced rectal cancer; however, resistance to chemoradiotherapy is one of the main obstacles to improving treatment outcomes. The goal of this study was to explore the role of PRDM15 involved in the radioresistance of colorectal cancer and to clarify the underlying mechanism.
Methods
The expression and localization of PRDM15 was measured with Western blot and immunofluorescence assay. Lenti-virus was applied to perform knockdown or overexpression of PRDM15. Colorectal cancer cells exposed to γ-rays were assayed by DNA damage, cytotoxicity, apoptosis and cell cycle. Moreover, DNA damage response was detected and immunoprecipitation was used to explore protein interactions. The potent role of PRDM15 in overcoming radioresistance was investigated in CDX and PDX models. Finally, the correlation between PRDM15 expression and clinical outcomes were investigated in 80 locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy.
Results
After DNA damage, PRDM15 was upregulated and localized to DNA damage sites, colocalized with γH2AX. Knockdown of PRDM15 inhibited DNA damage repair and increased radiosensitivity in colorectal cancer cells. Mechanistically, PRDM15 promoted DNA repair by interacting with DNA-PKcs and Ku70/Ku80 complex. Knockdown of PRDM15 sensitized CDX and PDX models to radiotherapy. Higher PRDM15 expression in cancer tissue was associated with inferior tumor regression and poorer prognosis in colorectal cancer patients treated with neoadjuvant chemoradiotherapy.
Conclusions
Our findings revealed that inhibiting PRDM15 was potent to overcome radioresistance through abrogating DNA repair in colorectal cancer cells. Additionally, the expression level of PRDM15 could be applied to predict radiotherapy responsiveness in rectal cancer patients.
Revisiting QUIC attacks: A comprehensive review on QUIC security and a hands-on study
Authors: Chatzoglou Efstratios , Kouliaridis Vasileios , Karopoulos Georgios , Kambourakis Georgios
Published: July 2022

Built on top of UDP, the recently standardized QUIC protocol primarily aims to gradually replace the TCP plus TLS plus HTTP/2 model. For instance, HTTP/3 is designed to exploit QUIC’s features, including reduced connection establishment time, multiplexing without head of line blocking, always-encrypted end-to-end security, and others. This work serves two key objectives. Initially, it offers the first to our knowledge full-fledged review on QUIC security as seen through the lens of the relevant literature so far. Second and more importantly, through extensive fuzz testing, we conduct a hands-on security evaluation against the six most popular QUIC-enabled production-grade servers. This assessment identified several effective and practical zero-day vulnerabilities, which, if exploited, can quickly overwhelm the server resources. This finding is a clear indication that the fragmented production-level implementations of this contemporary protocol are not yet mature enough. Overall, the work at hand provides the first wholemeal appraisal of QUIC security from both a literature review and empirical standpoint, and it is therefore foreseen to serve as a reference for future research in this timely area.
Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer evolution
Authors: Tsujioka Masatsune , Miyazawa Keisuke , Ohmuraya Masaki , Nibe Yoichi , Shirokawa Tetsuya , Hayasaka Haruko , Mizushima Tsunekazu , Fukuma Takeshi , Shimizu Shigeomi
Published: July 2022

Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. Nevertheless, we here identified a novel type of focal adhesion remodelling that occurs under genotoxic stress conditions, which involves the replacement of active focal adhesion kinase (FAK) with FAK-related non-kinase (FRNK). FRNK stabilized focal adhesions, leading to strong cell-matrices adhesion, and FRNK-depleted cells were easily detached from the matrices upon genotoxic stress. This remodelling occurred in a wide variety of cells. In vivo, the stomachs of Frnk-knockout mice were severely damaged by genotoxic stress, highlighting the protective role of FRNK against genotoxic stress. FRNK was also found to play a vital role in cancer progression, because FRNK depletion significantly inhibited cancer dissemination and progression in a mouse cancer model. We hence conclude that this novel type of focal adhesion remodelling reinforces cell adhesion and acts against genotoxic stress, which results in the protection of normal tissues, but, in turn, facilitates cancer evolution.