bluuebunny/crossref_metadata_2025 huggingface dataset:
Mild Traumatic Brain Injury, Hibernation, Type 2 Diabetes Common Etiopathophysiology Biomarkers and Function
Authors: Frye Cheryl A
Published: January 2024

The link between diabetes and traumatic brain injury (TBI) is an area worthy of exploration. TBI is caused by bumps, blow, jolt, or penetrating injury to the head. Even mild (mTBI) and moderate TBI frequently results in chronic cognitive, emotional and behavioral symptoms, which impact long-term outcome and functioning. Traumatic brain injury is associated with neuroendocrinopathies including hypothalamic, pituitary, adrenal, gonadal (HPAG axis), pancreatic and other hormonal dysfunctions. Increases in cortisol, cholesterol, and weight gain that can occur with some TBI can all survivors may contribute to Metabolic Syndrome and Type II diabetes. In addition, many patients with TBI find physical activity, proper eating and sleeping difficult. They also often experience anxiety and stress, which contribute to hormonal dysregulation. Taking a proactive approach in lifestyle to avoid becoming diabetic and careful monitoring to address issues can improve the quality of life of patients with TBI and prevent the likelihood of developing metabolic syndrome and Type II diabetes. We also show endocrine data of several different species in different phases or types of hibernation which can be informative.
MODY6 with NEUROD1 Mutation an Unusual Presentation in Adolescent: A Case Report
Authors: Pareek Kavita
Published: January 2024

MODY( Maturity onset diabetes of young) is a rare monogenic type of diabetes and which comprises 1-5 % of all diabetes cases [1]. It is often misdiagnosed as either type 1 or type 2 diabetes mellitus in children and adolescents due to common clinical signs and symptoms. With the availability of genetic testing, an increasing number of cases of MODY are being reported. We are reporting a case of 15 years old male child who presented with hyperglycemia without metabolic acidosis. He started on standard insulin regimen in view of suspected type1 diabetes. Later he was detected with NEUROD1 mutation, which is associated with MODY6, and the child was put on oral hypoglycemic drug, Metformin. At present the child is not on medication and is euglycemic. NEUROD1 is one of the least reported mutations in MODY6, only 5-6 cases are reported from India, and we report the youngest case.
Development of Tablets Based on Lannea Microcarpa Engl. Et K. Krause (Anacardiaceae) Extracts for Arterial Hypertension Therapy
Authors: Ouédraogo Salfo
Published: January 2024

In context of hypertension, research in African traditional medicine allows the identification of safe and effective recipes that lead to the development of phytomedicines or the isolation of molecules that can be used in managing of hypertensive patients.
Magic Methyl Effects in Drug Design
Authors: Shah Pritha
Published: January 2024

Methyl group is one of the most commonly occurring substituents in drugs. More than 50% of drugs with high market value have methyl groups in their structures. Methyl group has a capacity to act as Electron Donating Group and modulating physicochemical and biological properties of drug molecules. These properties include effect on half-life on a drug, selectivity, potency and binding affinity. When introduction of methyl group results in profound increase biological activity of molecules, it is known as Magic Methyl Effect. These enhancements in biological activity are attributed to effect of methyl group on free energy of Desolvation. The present review explores the origin of this magic methyl effect along with some supporting case studies in drug design.
Silane Modified Quaternary Ammonium Chloride Mediated Hygienic Uniform Fabrics
Authors: Desai K.U.
Published: January 2024

This study aims to develop uniform fabrics for different industrial environments. The study also saw the types and effects of microbes as well as chemicals used to protect the uniform fabrics against their attack under the environment of different corporate industries. This work reports the influence of Alkoxy alkylsilyl dimethyl octadecyl ammonium chloride on anti-bacterial properties of cotton (C), polyester/cotton (P/C) and polyester/viscose (P/V) blended fabric samples. Fabric samples were treated with silane modified dimethyl octadecyl quaternary ammonium chloride compound by the pad-dry-cure method. The influence of this treatment on treated fabrics in terms of antimicrobial activity was measured as per AATCC 100 quantitative method. Improvement in the anti-bacterial activity was observed for all the fabric samples but the improvement in cotton fabric is worth mentioning. This work is a sincere attempt to prepare hygienic common textiles at economical rates using continuous application technique which offers durable efficacy against the human pathogenic bacterium.
Futuristic Progress of Natural Emulsifiers in the Enhancement of Drug Delievery System and their Applications in Selected Medical Therapeutics
Authors: Singla Shivam 
Published: January 2024

Food manufacturers are being encouraged to employ more natural and sustainable food components as a result of consumer concerns about human and environmental health. Synthetic components are being replaced with natural ingredients, while animal-based ingredients are being replaced with plant-based elements. Phospholipids, biosurfactants, proteins, polysaccharides, and natural colloidal particles are some of the natural emulsifiers that might be used in the food sector. Natural emulsifiers may be used more frequently in food items, resulting in a healthier and more sustainable food supply. More study is needed, however, to find, isolate, and characterize novel sources of economically viable natural emulsifiers suited for food applications. Foods, cosmetics, detergents, and personal care items are among the commercial products that are under increasing consumer demand to be more natural, sustainable, and ecologically friendly. As a result, the industry has attempted to develop natural alternatives to synthetic functional components in these goods. Natural emulsifiers such as amphiphilic proteins, polysaccharides, biosurfactants, phospholipids, and bioparticles are being used to replace synthetic surfactants. The physicochemical foundation of emulsion generation and stability by natural emulsifiers is explored in depth, as well as the benefits and limits of various natural emulsifiers. Single emulsions, such as water-in-oil and oil-in-water, and multiple emulsions, such as water-in-oil-in-water, are the most common types of emulsions. Emulsifier / emulgent is a chemical that increases the kinetic energy of an emulsion to stabilise it. Emulsifiers are separated into four types based on their chemical structure: synthetic, natural, finely split solids, and auxiliary agents; and three types based on their mode of action: monomolecular films, multimolecular films, and solid particle films. Surface tension theory, surface orientation theory, and plastic/interfacial film theory are some of the ideas that aid in the understanding of the emulsification process. emulsion, natural emulsifiers, biosurfactants, emulsion technology, water-in-oil.
Forensic Entomotoxicology: A Brief Look at Sample Preparation Techniques – A Review
Authors: de Bairros André Valle
Published: January 2024

Forensic entomotoxicology is a relatively new science whose applications aims the detection of toxic substances through a matrix of necrophagous insects in a crime scene. In addition, it aims the investigation of the impacts of the xenobiotics on these insects, generating impacts in the measurement of the post-mortem interval (PMI). Calliphoridae larvae, the most important insect for forensic entomology, has an average amount of 25% of crude fat and 53% of crude protein, being a complex matrix that requires some sample preparation methodology before inserting the sample in some equipment to perform the chemical instrumental analysis. Sample preparation methods should be applied in order to increase the protection of analytical equipment from impurities present in the arthropod matrix, as well as increase the detectability of the test analyte by the analytical instrumentation of choice. Thus, the objective of the present work is to compile sample preparation techniques since traditional procedures until new approaches found in the scientific literature applied for entomotoxicological analysis in Calliphoridae specimens and respective analytes. It was observed the lack of a complete standardization for entomotoxicological approach, mainly for traditional extractions preparations. In this sense, microextraction-based techniques become an even greater challenge for arthropod–like matrix, especially in specimens from Calliphoridae family for xenobiotics determination. So, the development of sample preparation techniques with more sustainable approaches, such as reduced use of solvents, added to the increase of the powerfulness of analytical instrumental techniques should be encourage in order to improve the forensic entomotoxicology approach.
Orally Disintegrating Tablet: A Review
Authors: Singh Bhavana 
Published: January 2024

Orally dispersive tablets are solid dosage forms that dissolve in the mouth in within 10 to 30 seconds, enabling waterless ingestion. The tablet dissolves quickly due to its fast breakdown, which also causes the effects to start acting quickly. ODTs can help patients with a variety of conditions, including paediatrics, geriatrics, psychosis, dysphagia, bedridden discomfort, comatose patients, young patients with undeveloped muscular and nervous systems, patients with hand tremors, and patients who travel often. It provides high stability, precise dosage, efficient manufacture, and smaller packing; self-administration is allowed on long journeys because water is not required. ODTs are a cost-effective way to distribute drugs. When a medicine is absorbed through the buccal cavity, ODTs constitute a critical drug delivery method. Spray drying, sublimation, and other scientific procedures like freeze drying, moulding, and direct compression. The availability of ODTs as over-the-counter drugs for the treatment of a range of illnesses is increasing. This article’s objective is to go over the benefits, drawbacks, formulation difficulties, manufacturing methods, patented technologies, commercially available formulations, and evaluation checks of ODT. The word “Oro dispersible tablets” was created by the European Pharmacopoeia. This is an uncoated tablet that dissolves easily in the mouth for 3 minutes before being swallowed.
Medication Therapy Management: Predicting the Future?
Authors: E Roane Teresa
Published: January 2024

This article discusses medication therapy management programs and how changes have evolved (or lack thereof) since their inception in 2006. In 2017, the Centers for Medicare & Medicaid Services launched a pilot program, called the enhanced medication therapy management program, allowing specifically chosen health plans greater flexibility and enrollment options as compared to their traditional medication therapy management programs. This pilot program also incorporated a standardized coding language system with the hopes of being able to consistently evaluate the various programs and ultimately seeing a cost-savings benefit for the overall healthcare system and the patient. To date, the pilot has fallen short of this goal although another year of data is currently under review. Based on the information from the pilot program evaluation so far, it brings up a good question: what does the future of medication therapy management programs look like or what else can be done to improve outcomes and show value? A few options that could be considered include utilizing advances in technology to enhance patient engagement and/or combining other patient care programs (such as comprehensive medication management and pharmacogenomics) into existing medication therapy management programs to provide individualized patient-centered care and ultimately showing the value of such great clinical care programs led by pharmacists.
Synthesis of Acetaminophen by Microwave Irradiation Catalyzed on H-Clinoptilolite
Authors: Torosyan G H
Published: January 2024

The interaction of p-aminophenol with acetic anhydride under microwave irradiation in the presence of H-clinoptilolite was studied during our research on finding economic and ecological methods for the synthesis of acetaminophen (paracetamol). It has been established the effectiveness of the proposed system has been established, which allows the synthesis of the most important drug in a short time with a high yield.
Deteksi Antibodi Terhadap Covid-19 pada Anjing dan Kucing di Indonesia
Authors: Arios Yunetta Putri , Pamungkas Joko , Wibawan I Wayan Teguh , Iskandriati Diah , Sriyanto Sriyanto , Yusmanto Andi PM
Published: January 2024

Di Indonesia sampai saat ini tidak banyak publikasi data terkait status epidemi Covid-19 yang disebabkan Severe Acute Respiratory Syndrom Coronavirus 2 (SARS-CoV-2) pada anjing dan kucing. Beberapa penelitian di negara lain menunjukkan prevalensi antibodi yang relatif tinggi pada anjing dan kucing dengan riwayat kontak erat dengan manusia yang terinfeksi Covid-19. Hal ini menunjukkan mudahnya penularan dari manusia ke hewan kesayangan. Data dan kajian mengenai kejadian Covid-19 pada anjing dan kucing yang berada di Indonesia maupun yang dilalulintaskan dapat memberikan informasi awal terkait keberadaan penyakit ini pada hewan kesayangan. Studi ini dilakukan untuk melihat keberadaan SARS-CoV-2 pada anjing dan kucing serta respons kebal yang terbentuk. Sampel yang digunakan diperoleh dari hewan yang berasal dari berbagai negara dan beberapa klinik di Indonesia. Sebanyak (128 serum kucing dan 53 serum anjing) diuji menggunakan metode Indirect Enzym Linked Immunosorbant Assay (ELISA) sedangkan sampel usap/swab orofaringeal yang terdiri atas 1.499 swab asal kucing dan 958 swab asal anjing diuji menggunakan metode Real Time Reverse Transcription-Polymerase Chain Reaction. Berdasarkan hasil uji terdeteksi antibodi terhadap SARS-CoV-2 terdapat pada dua ekor anjing (3,8 %) dan enam ekor kucing (4,7 %). Uji kuantitatif PCR tidak menunjukkan adanya virus pada semua sampel yang diuji. Hasil studi ini dapat memberikan informasi awal untuk melakukan studi epidemiologi lanjutan terkait infeksi SARS-CoV-2 pada hewan kesayangan.
Pemberian Monosodium Glutamat Selama Masa Organogenesis Meningkatkan Perkembangan Embrio Cacat pada Mencit
Authors: Savitri Lisa , Kasimo Elfred Rinaldo , Krissanjaya Rochmad
Published: January 2024

Monosodium glutamate (MSG) biasanya berbentuk kristal halus dan berwarna putih. Senyawa MSG dibuat melalui proses fermentasi dari bahan dasar pati (gandum) dan gula molasses (tetes tebu) yang diberi nama sebagai garam natrium dan asam glutamat. Pemberian MSG selama induk mencit bunting bersifat embriotoksik. Penelitian ini bertujuan untuk mengetahui efek toksik MSG pada perkembangan embrio selama masa organogenesis. Penelitian pemberian MSG terhadap mencit dimulai pada kebuntingan hari ketujuh yaitu pada tahap organogenesis. Perlakuan dosis MSG yang diberikan adalah dosis 528 mg/kg BB, 696 mg/kg BB, dan 872 mg/kg BB. Peubah yang diamati dalam penelitian ini adalah jumlah fetus hidup atau mati dalam rahim pada kebuntingan hari ke-18, di samping morfologi fetus, bobot fetus dan perkembangan tulang rangka fetus. Hasil penelitian menunjukkan bahwa pemberian MSG yang dilakukan secara terus menerus sejak kebuntingan hari ke-7 hingga 16 membuat MSG tersebut masuk ke dalam tubuh induk mencit yang tidak memiliki kemampuan untuk menetralisir dan mendetokfikasi senyawa-senyawa kimia sehingga terakumulasi pada embrio mencit. Zat-zat tersebut mencapai embrio melalui pembuluh darah dan memengaruhi perkembangan fetus mencit. Penelitian ini menunjukkan bahwa ada pengaruh MSG terhadap perkembangan fetus mencit (Mus musculus) selama periode organogenesis di antaranya yaitu kecacatan pada mata (mikropthalmia dan anoftalmia), hidrosefalus ringan, jumlah metakarpal, jumlah metatarsal, dan ruas cervikal vertebrae tidak sama panjang. Abnormalitas perkembangan fetus mencit selama periode organogenesis meningkat sejalan dengan peningkatan dosis MSG yang diberikan dan bervariasi antar perlakuan. Semakin tinggi dosis MSG yang diberikan pada induk mencit bunting, maka semakin sedikit jumlah fetus yang hidup. Dapat disimpulkan bahwa MSG memengaruhi perkembangan fetus mencit selama masa organogenesis.
Preparação de informações e envolvimento da comunidade para o El Niño na região da África Oriental e Austral
Authors: Rohan Hana
Published: January 2024

O El Niño pode ser encarado como um fenómeno de múltiplos perigos e as considerações sobre as necessidades de informação devem abranger diferentes populações e riscos, incluindo perigos diretos relacionados com o clima, redução da produção agrícola, maior insegurança alimentar e subnutrição, aumento da transmissão de doenças infeciosas e efeitos no acesso aos cuidados de saúde. As comunicações de alerta de riscos a longo e a curto prazo podem ter de incluir diferentes apelos à acção e é provável que haja diferentes níveis de urgência para esses apelos. Este relatório de considerações fundamentais descreve as implicações do El Niño na Região da África Oriental e Austral (ESAR) para as iniciativas de Comunicação de Riscos e Envolvimento Comunitário (CREC), com base em fenómenos meteorológicos similares anteriores. As lições aprendidas são predominantemente retiradas da literatura sobre a comunicação de previsões e informações meteorológicas, mas têm implicações para a resposta de CREC de múltiplos perigos. Algumas lições aprendidas são também retiradas de fora da África Oriental e Austral, mas consideradas especificamente no âmbito dos efeitos previstos do El Niño na ESAR. A primeira secção do relatório incide sobre as necessidades de informação, a segunda secção é sobre como garantir e criar confiança na informação, e a secção final diz respeito às estratégias de comunicação e envolvimento da comunidade. O relatório foi solicitado pelo Collective Service como um recurso para as organizações que trabalham na CREC relacionada com o El Niño na ESAR.
First record of Tandonia budapestensis (Hazay, 1880) (Gastropoda: Stylommatophora: Milacidae) from Bosnia & Herzegovina with additional notes on the occurrence of Tandonia kusceri (H. Wagner, 1931)
Authors:   Department of Morphology, Systematics and Phylogeny of Animals, University of Belgrade, Faculty of Biology, Studentski trg 16, 11000, Belgrade, Serbia, Gojšina Vukašin , Stanković Mihajlo ,   SRP Zasavica – Pokret gorana, 22000 Sremska Mitrovica, Srbija
Published: January 2024

In this paper, we present the first records of the Budapest slug, Tandonia budapestensis (Hazay, 1880), from five localities in Bosnia & Herzegovina. We provide a detailed description of the external morphology and reproductive system of the specimens. We also speculate on the presence of Tandonia kusceri (H. Wagner, 1931) in Bosnia & Herzegovina, based on the present distribution and spread of the species and one photo posted on a social media platform.
Aleurocanthus camelliae Kanmiya & Kasai, 2011 (Hemiptera: Aleyrodidae), a newly intercepted whitefly species in Croatia
Authors:   Hrvatska agencija za poljoprivredu i hranu, Centar za zaštitu bilja, Gorice 68b, 10000 Zagreb, Šimala Mladen , Pintar Maja ,   Hrvatska agencija za poljoprivredu i hranu, Centar za zaštitu bilja, Gorice 68b, 10000 Zagreb, Markotić Vjekoslav ,   Hrvatska agencija za poljoprivredu i hranu, Centar za zaštitu bilja, Gorice 68b, 10000 Zagreb
Published: January 2024

The Camellia spiny whitefly Aleurocanthus camelliae Kanmiya & Kasai, 2011 (Hemiptera: Aleyrodidae) was intercepted for the first time during 2022 in consignments with ornamental Camellia spp. seedlings originating from Italy, in seven plant nurseries and garden centres in Croatia. This Eastern Palearctic whitefly species is an important pest, especially in tea cultivation of East Asia. However, in Croatia the species has been detected at very low population densities without any significant damage to the infested ornamental plants of the genus Camellia L. From the infested leaves collected on each location, whitefly puparia and pupal cases were slide-mounted and morphologically identified in laboratory as the species A. camelliae. It is assumed that in the case of spreading and domestication in Croatia, A. camelliae could potentially present a phytosanitary risk for the camellias planted in gardens and parks in the Kvarner area.
Phytosociological study of the vascular plant communities of the lower Neretva delta (southeastern Adriatic)
Authors:   University of Dubrovnik, Institute for Marine and Coastal Research, Kneza Damjana Jude 12, POBox 83, HR-20000 Dubrovnik, Croatia, Jasprica Nenad
Published: January 2024

The Neretva delta (estuary) is an internationally important wetland included in the Ramsar list and is one of the Important Plant Areas (IPA) in Croatia. The paper presents data from phytosociological research collected in the lower Neretva delta in the period 2006-2021. Based on 28 phytosociological relevés, 15 associations and one subassociation were identified and classified into 13 alliances, 12 orders and 11 vegetation classes. The most valuable communities belong to halo-nitrophilous short-lived pioneer vegetation on sand and gravel beaches (Cakiletea maritimae) and salt-marsh herblands and scrub (Therosalicornietea, Salicornietea fruticosae). Anthropogenic impacts on the delta are strong, and the diversity of flora and vegetation is threatened by habitat degradation and loss, unsustainable exploitation of natural resources, and pollution.
New records and distribution data of stoneflies (Insecta: Plecoptera) from the Western Balkans
Authors:   Faculty of Agribusiness, University of Peja Haxhi Zeka, UÇK street, 30 000 Pejë, Republic of Kosovo, Bilalli Astrit , Ibrahimi Halil ,   Department of Biology, Faculty of Mathematics and Natural Sciences, University of Prishtina Hasan Prishtina, Mother Theresa p.n., 10 000 Prishtinë, Republic of Kosovo, Musliu Milaim ,   Faculty of Agribusiness, University of Peja Haxhi Zeka, UÇK street, 30 000 Pejë, Republic of Kosovo, Grapci-Kotori Linda ,   Department of Biology, Faculty of Mathematics and Natural Sciences, University of Prishtina Hasan Prishtina, Mother Theresa p.n., 10 000 Prishtinë, Republic of Kosovo, Slavevska-Stamenkovič Valentina ,   Institute of Biology, Faculty of Natural Sciences and Mathematics, Gazi Baba bb, 1000 Skopje, Republic of North Macedonia, Hinič Jelena ,   Institute of Biology, Faculty of Natural Sciences and Mathematics, Gazi Baba bb, 1000 Skopje, Republic of North Macedonia, Geci Donard ,   Department of Biology, Faculty of Mathematics and Natural Sciences, University of Prishtina Hasan Prishtina, Mother Theresa p.n., 10 000 Prishtinë, Republic of Kosovo, Sivec Ignac ,   Slovenian Museum of Natural History, Presernova 20, 1000 Ljubljana, Slovenia
Published: January 2024

The knowledge about stoneflies of the Balkan Peninsula is still not complete, with many areas poorly investigated. During this investigation, we collected adult stonefly specimens from Kosovo, Albania, North Macedonia, Serbia and Montenegro during the period 2014-2018. In total, we found 42 species belonging to 14 genera and 7 families. Five species are recorded for the first time for Kosovo (Leuctra cingulata Kempny, 1899, Leuctra cf. olympia Aubert, 1956 Nemoura cf. lucana Nicolai & Fochetti, 1991, Nemoura uncinata Despax, 1934 and Brachyptera macedonica Ikonomov, 1983), one is recorded for the first time for Serbia (Nemoura asceta Murányi, 2007) and one for Albania (Leuctra major Brinck, 1949). This investigation contributes to the knowledge of distribution patterns of stoneflies species in the Balkan Peninsula.
¿Las indemnizaciones adicionales en los casos de extinción del contrato de trabajo a las reguladas en el Estatuto de los Trabajadores son válidas?
Authors: García Viña Jordi
Published: January 2024

En las normas laborales hay diversos supuestos en los que el empresario debe pagar determinadas indemnizaciones por sus conductas, especialmente en casos de extinción del contrato de trabajo donde, desde 1980, existe una regulación fundamentada en un baremo objetivo y predeterminado, según el salario y la antigüedad del trabajador. A partir de la pandemia y fruto de la regulación específica dictada en aquel período, diversos tribunales se han planteado la posibilidad de conceder una indemnización adicional entendiendo que la cuantía legal tasada no es suficientemente disuasoria. Los tribunales, fundamentándose en el control de convencionalidad, han entendido aplicable el art. 24 de la Carta Social Europea (revisada), así como la interpretación que ha realizado en diversas decisiones el Comité Europeo de Derechos Sociales del Consejo de Europa. Sin embargo, sólo una sentencia del Tribunal Superior de Justicia de Cataluña de 30 de enero de 2023 ha concedido una indemnización adicional
Geschlechtsidentitäten in der technologisch und digital vernetzten Gesellschaft
Authors: Hlukhovych Adrianna
Published: January 2024

Anhand exemplarischer theoretischer Ansätze der Gender-, Medien-, und Technologieforschung beleuchtet der Beitrag aus medienkulturwissenschaftlicher Sicht das Verhältnis von Medien und Geschlechtern im Hinblick auf die Gegebenheiten und Entwicklungen der technologisch und digital vernetzten Gesellschaft. Die Erörterung dieses Verhältnisses erfolgt im diachronen Schnitt und anhand der Wandlungs- und Aushandlungsprozesse zwischen den medien bzw. technikzentrierten Positionen hinsichtlich der Konstruktion der Geschlechter und ihren Repräsentationen in den (digitalen) Medien auf der Ebene der medialen Botschaften: angefangen mit den Erkenntnissen der feministischen und Gender-Studien, über den Cyberfeminismus bis hin zu den Einsichten des Neuen Materialismus und des kritischen Posthumanismus.
Geschlechterunterschiede beim Einsatz digitaler Medien im Berufsschulunterricht : Ergebnisse zum Unterrichtsalltag mit Tablets
Authors: Wagner Anne
Published: January 2024

Im Zuge der Digitalisierung ändern sich die betrieblichen Arbeitsprozesse und Tätigkeitsformen. Die neuen Anforderungen der Gesellschaft 4.0 müssen im berufsschulischen Unterricht aufgegriffen und entsprechend simuliert werden müssen. Die Zielstellung beruflicher Bildung ist die Vorbereitung junger Menschen auf eine zukünftige berufliche Tätigkeit. Zahlreiche Studien haben jedoch Unterschiede zwischen Jungen und Mädchen hinsichtlich der Nutzung von digitalen Medien sowie in den Einstellungen gegenüber diesen festgestellt. Im Rahmen des Projektes tabletBS.dual wurden Unterrichtssequenzen mit Tablets zur Simulation der veränderten Anforderungen in beruflichen Handlungssituationen entwickelt und mittels Tagebuchverfahren und quantitativer Begleiterhebung evaluiert. Ziel des Beitrags ist es, erste Ergebnisse der Tagebuchstudie zum berufsschulischen Unterricht mit digitalen Medien sowie der Begleiterhebung vorzustellen und dabei bestehende Geschlechterunterschiede in den Blick zu nehmen. Hinsichtlich digitaler Medien im Unterricht zeigt sich, dass entgegen bestehender Vorurteile in Hinblick auf das Zusammenspiel von Geschlecht und Digitalisierung kein signifikanter Unterschied zwischen Schülerinnen und Schülern im Bezug auf die Selbstwirksamkeit im Umgang mit digitalen Medien und kein signifikanter Zusammenhang zwischen dem Geschlecht und dem Medieneinsatz – traditionell, digital oder kombiniert – in wirksamen Lernerlebnissen vorliegen.
Losing Weight, a Matter of Gender? : Identification and Integration of Gender-Specific Psychological Factors in the Treatment of Obesity
Authors: Seiferth Caroline
Published: January 2024

The prevalence of unhealthy overweight and obesity among women and men worldwide has tripled in recent decades and continues to rise steadily according to the World Health Organization. Obesity is associated with negative health and with negative psychosocial as well as social consequences. These negative consequences can be reduced by a multidisciplinary treatment approach (nutritional, exercise and behavioral therapy). However, long-term successful weight reduction is a challenge for women and men who have obesity. Previous empirical studies show that there are psychological factors that promote or impede successful weight loss (e.g. self-efficacy, self-control, coping strategies). For many of these psychological factors gender differences have been detected that have so far not been taken into account in the treatment of obesity. In order to do so effectively, digital health services (e.g. health apps) should be used that integrate weight-associated psychological aspects into weight loss and weight maintenance programs. The technical capabilities of digital services allow persons with obesity to adapt treatment individually to their own gender-specific needs. This is a promising approach to improve successful long-term weight loss for both women and men. This article reviews findings on gender-specific differences in psychosocial factors affecting obesity and obesity treatment. Furthermore, it introduces the app-based psychological intervention I-GENDO, which represents an approach combining digitalization and gender aspects in the treatment of obesity. Finally, it argues that the app can increase the effectiveness of conventional weight reduction programs.
Small Signal Stability Analysis of Kalimantan 500 KV Electricity System
Authors: Agus Sadid Akbar Syahbani , Mutiarso Ismayahya Ridhan , Arif Fauzany , Muda Kemal Iskandar , Prawira Fadhil Bintang
Published: January 2024

Small signal stability refers to the ability of a system to return to equilibrium after experiencing a small disturbance. In this research, the Kalimantan electricity system will be analyzed for the stability of its small signal. Analysis of the stability of small signals in electrical systems including local disturbances and inter-area disturbances. The Kalimantan system will be analyzed using Power Factory software. System analysis was carried out by evaluating the eigenvalues ​​(real part and imaginary part), oscillation frequency (damped frequency and frequency ratio) produced in the Kalimantan 500 KV electricity analysis. In the analysis results, the Kalimantan system is categorized as stable as indicated by the real part and imaginary part values ​​located on the negative side of the Cartesian coordinate curve. Then, analyzing small signals, there are 117 modes categorized as local mode and 4 modes categorized as inter area mode.
REB Indexes
Authors: Aukutsionek S. , Batyaeva A. , Demina N. , Egorov A. , Matveev A.
Published: January 2024

“REB indexes” cover a wide range of economic indicators of Russian industrial enterprises. The article presents basic statistical data collected on a monthly, quarterly and semi-annual base by the Russian Economic Barometer by means of direct questioning of managers of industrial and agricultural enterprises. Regular extension of rows allows seeing dynamics of more than 70 series of indicators and conducting comparative analysis of data collected since 1991.
Pandemic Restrictions Are Over: An Overview of Changes in the Main Economic Indicators of Enterprises. Part 2. Investment activity of enterprises and changes in the output structure
Authors: Batyaeva A.
Published: January 2024

The article considers several aspects of the investment activity of enterprises (the involvement of enterprises in investment activity, the effectiveness of investments, the payback period, the availability of investment loans, product and technological innovations and changes in the structure of output). The main target is to compare various characteristics of the investment behavior of enterprises during the period of COVID restrictions with the situation before their introduction and immediately after their removal. Contrary to popular expectations, COVID restrictions did not cause the collapse of the enterprises’ investment activity. At the first stage of the pandemic, this activity stabilized, and then began to grow. COVID had a smaller negative effect on the investment activity of industrial enterprises than the crises of 1998–1999, 2008–2009 and 2014–2015. During the period of restrictions, the effectiveness of investments turned out to be lower than the previous highs, but in general it corresponded to the level of long-term averages. Industrial enterprises traditionally face great difficulties in obtaining investment loans. In this regard, the isolation of enterprises from the banking sector was increasing during the COVID period, but this negative trend appeared earlier, before COVID.
The 2022 Surveys of Industrial Enterprises: Results and Forecasts
Authors: Aukutsionek S.
Published: January 2024

The article presents the results of economic activity of Russian industrial enterprises in 2022, and provides forecasts for 2023. In general, for the major part of the surveyed enterprises (REB’s respondents) the year 2022 turned out to be not worse than the preceding one, and some indicators reached record levels. Forecasts for 2023 also inspire certain optimism.
The grouping of industrial enterprises by capacity utilization rate and level of debts to banks (IV Quarter of 2022)
Authors: Aukutsionek S. , Demina N. , Bashirova I. , Serzhantova T.
Published: January 2024

Russian industrial enterprises, examined by the «Russian Economic Barometer» are grouped according to two criteria: the level of capacity utilization rate, as well as the level of debts to banks. This grouping allows you to see how key characteristics of enterprises differ depending on how their production capacities are loaded and what level of debts to banks they have. Data are presented for the fourth quarter of 2022.
Multimodality Imaging in Right Heart Tumors: A Practical Algorithm towards an Appropriate Diagnosis
Authors: Floria Mariana , Burlacu Alexandru , Morariu Paula Cristina , Oancea Alexandru-Florinel , Iov Diana Elena , Baroi Genoveva Livia , Stafie Celina Silvia , Scripcariu Viorel , Tanase Daniela Maria
Published: January 2024

Right heart masses are usually suspected during a routine examination by transthoracic echocardiography or due to cardiac symptoms. Although very important, sometimes it may be a challenge to differentiate between normal structures (variants) and aberrant or pathologic masses regarding the right heart cardiac tumors. In the last entity, the majority of primary cardiac tumors in adults and children are benign; however, they may have a malignant counterpart. Right heart tumors might involve not only the walls (myocardium, endocardium and pericardium), but also valves and cardiac chambers. Cardiac tumors exhibit altered signal intensity and enhancement characteristics, requiring the use of several imaging methods following a multimodality-imaging algorithm that culminates in the excision or biopsy of the tumor formation. Therefore, various imaging modalities, including echocardiography, computer tomography, positron emission tomography, cardiac magnetic resonance imaging, scintigraphy or, even, invasive angiography, can be useful during their diagnosis. Echocardiography is the first-line non-invasive imaging modality used in the evaluation of the right heart tumors. Before the other diagnosis imaging modalities it is essential for defining morphology, assessing size, observing dynamic appearance, and evaluating functional abnormalities and hemodynamic consequences,. However, all imaging methods have frequently a complementary role; therefore, an integrated imaging approach is recommended.
Expression Profiling Uncovers Novel Genes Associated with Plant Hormone Signal Transduction Involved in Regulation of Anthocyanin Biosynthesis in Red-Fleshed Apple Cultivars
Authors: Keller-Przybylkowicz Sylwia , Oskiera Michal , Liu Xueqing , Song Laiquing , Zhao Lingling , Du Xiaoyun , Kruczyńska Dorota E. , Walencik Agnieszka , Kowara Norbert Jakub , Bartoszewski Grzegorz
Published: January 2024

Apple red flesh coloration is a result of the performance of biochemical pathway involved in the biosynthesis of anthocyanins and anthocyanidins. Based on apple genome analysis, high number of regulatory genes, mainly transcription factors such as MYB, which are components of regulatory complex MYB-bHLH-WD40, and several structural genes (PAL, 4CL, CHS, CHI, F3H, DFR, ANS, UFGT) involved in anthocyanin biosynthesis have been identified so far. In this study, we investigated previously unrecognized genes involved in the constitution of red-flesh apple phenotype. These genes could be concerned as molecular markers for early selection of new apple cultivars. Based on comparative transcriptome analysis of apples with different fruit flesh coloration, we successfully identified and characterized ten genes from plant hormone transduction pathway of: auxin (GH3); cytokinins (B-ARR); gibberellins (DELLA); abscisic acid (SnRK2 and ABF); brassinosteroids (BRI1, BZR1 and TCH4); jasmonic acid (MYC2); and salicylic acid (NPR1). In presented studies an analysis of their expression profiles was performed in immature and ripe fruits of red-fleshed cultivars. Generally, we have uncovered, the set of the novel genes, mediating regulation of the abscisic acid, salicylic acid, cytokinins and jasmonic acid signaling and preliminarily described their role in anthocyanin biosynthesis, accumulation and degradation. Their expression was not characterized in apple fruits so far. Presented study, allowed to underline the relationship of genes from hormone signal transduction pathway with UFGT gene, directly responsible for anthocyanin color transformation as well as confirmed their crucial role of plant hormone regulation and anthocyanin accumulation during apple fruit ripening.
Impact of Ukrainian refugees on the COVID-19 pandemic dynamics after February 24, 2022
Authors: Nesteruk Igor , Brown Paul E.
Published: January 2024

On February 24, 2022 Russia started the full-scale invasion of Ukraine, which created an unprecedented number of refugees. To estimate the influence of this humanitarian disaster on the COVID-19 pandemic dynamics, the averaged daily numbers of cases and reproduction numbers in Ukraine, the UK, Poland, Germany, the Republic of Moldova, and in the whole world were calculated for the period February-April 2022. The registered numbers of cases were compared with ones calculated with the use of the generalized SIR-model and corresponding parameter identification procedure for the previous epidemic waves in Ukraine, Poland, Germany, and the world. Since before February 24, 2022 the estimation of the number of infectious persons per capita in Ukraine 3.6 times exceeded the global figure, the increase of the number the new cases and the pandemic duration was expected. In March 2022 the increase of the averaged number of new cases in the UK, Germany, and worldwide was visible. A simple formula to estimate the effective reproduction number based on the smoothed accumulated numbers of cases is proposed. The results of calculations agree with the figures presented by John Hopkins University and demonstrate a short-term growth of the reproduction number in the UK, Poland, Germany, Moldova, and worldwide in March 2022.
Placental mRNA expression of Neurokinin B is increased in PCOS pregnancies with female offspring.
Authors: Markantes Georgios K , Panagodimou Evangelia , Koika Vasiliki , Mamali Irene , Kaponis Apostolos , Adonakis George , Georgopoulos Neoklis A
Published: January 2024

Current research suggests that polycystic ovary syndrome (PCOS) might originate in utero and implicates the placenta in its pathogenesis. Kisspeptin (KISS1) and neurokinin B (NKB) are produced by the placenta in high amounts, and they have been implicated in several pregnancy complications associated with placental dysfunction. However, their placental expression has not been studied in PCOS. We isolated mRNA after delivery from the placentae of 31 PCOS and 37 control women with term, uncomplicated, singleton pregnancies. The expression of KISS1, NKB, and neurokinin receptors 1, 2, and 3 was analyzed with real-time polymerase chain reaction, using β-actin as the reference gene. Maternal serum and umbilical cord levels of total testosterone, sex hormone binding globulin (SHBG), free androgen index (FAI), androstenedione, dehydroepiandrosterone sulfate (DHEAS), Anti-Mullerian hormone (AMH), and estradiol were also assessed. NKB placental mRNA expression was higher in PCOS versus controls in pregnancies with female offspring. NKB expression depended on fetal gender, being higher in pregnancies with male fetuses. NKB was positively correlated with umbilical cord FAI and AMH, and KISS1 with cord testosterone and FAI; there was also a strong positive correlation between NKB and KISS1 expression. Women with PCOS had higher serum AMH and FAI and lower SHBG than controls. Our findings indicate that NKB might be involved in PCOS-related placental dysfunction, and warrant further investigation. Studies assessing the placental expression of NKB should take fetal gender into consideration.
Development of an Immunocapture-Based Polymeric Optical Fiber Sensor for Bacteria Detection
Authors: Lopes Rafaela Nascimento , Pinto Paulo Henrique Silva , Vargas Juan David Lopez , Dante Alex , Macrae Andrew , Allil Regina Celia Barros , Werneck Marcelo Martins
Published: January 2024

Conventional methods for pathogen detection in water rely on time-consuming enrichment steps followed by biochemical identification strategies, which require assay times ranging from 24 hours to up to a week. However, in recent years, significant efforts have been made towards the development of biosensing technologies enabling rapid and close-to-real-time detection of waterborne pathogens. In previous studies, we developed a plastic optical fiber (POF) immunosensor using an optoelectronic configuration consisting of a U-Shape probe connected to an LED and a photodetector. Bacterial detection was evaluated with the immunosensor immersed in a bacterial suspension in water with a known concentration. Here, we report on the sensitivity of a new optoelectronic configuration consisting of two POF U-Shape probes, one as the reference and the other as the immunosensor, for the detection of Escherichia coli. In addition, another way of detection was tested where the sensors were calibrated in the air, before immersed in bacterial suspension and then read in the air, making the immunosensor more sensitive and with a faster detection time. This new sensor detected the presence of E. coli at 104 CFU/mL in less than 10 minutes. Currently sub 10 minutes is faster than previous studies using fiber-optic based biosensors. It is also a much simpler and quicker methodology when compared with conventional laboratory technology.
Robustness of Corner-Supported Modular Steel Buildings with Core Walls
Authors: Hajirezaei Ramtin , Sharafi Pejman , Kildashti Kamyar , Alembagheri Mohammad
Published: January 2024

This paper studies the dynamic response of corner supported modular steel buildings with a core wall system, under progressive collapse scenarios, associated with corner module removals. Since using secondary systems such as concrete core in mid- to high-rise buildings is currently una-voidable, understanding their impact on load transfer between modules during collapse scenarios becomes essential. The designated buildings with four-, eight- and twelve-story were modelled using the macro-model based finite element method in Abaqus. Also, three different locations are considered for the concrete shear core within the building plan, leading to nine various case scenarios. Each vertical and horizontal inter-module connection was modelled by one axial and two shear springs with predefined nonlinear force-displacement behaviour. The local and global buckling, which plays an essential role in the building's stability, was considered to obtain accurate results. Finally, parametric studies on the building response were carried out, including the intra-module connection rigidity and inter-module connection stiffness. The results demonstrated that the core wall could maintain the robustness of modular steel building through two mechanisms dependent on its location within the plan. Also, preventing plastic hinges from forming in beams could be introduced as an anti-collapse mechanism in the corner module removal scenarios
Implementing the Dynamic Feedback-Driven Learning Optimization Framework: A Machine Learning Approach to Personalize Educational Pathways
Authors: Song Chuanxiang , Shin Seong-Yoon , Shin Kwang-Seong
Published: January 2024

This study introduces the Dynamic Feedback-Driven Learning Optimization Framework (DFDLOF), an innovative machine learning-based approach to personalize educational pathways. DFDLOF leverages advanced algorithms for in-depth analysis of learner data, enabling the dynamic customization of educational content and methodologies. Its application in diverse online platforms, including Khan Academy and Coursera, underscores its adaptability and scalability. DFDLOF enhances learner engagement and outcomes by providing tailored learning experiences and real-time feedback. Key insights reveal its strengths in personalized education, particularly in dynamically adapting learning paths and the importance of real-time feedback. Challenges identified include integration complexities and data privacy concerns. Future research directions emphasize the need for longitudinal impact studies and broader demographic applications. This study contributes significantly to the evolving domain of adaptive learning technologies, demonstrating the transformative potential of machine learning in personalizing education.
Impact of Technology Teaching in the Dental Predoctoral Curriculum on Students’ Perception of Digital Dentistry
Authors: Nassani Leonardo M. , Bencharit Sompop , Schumacher Fernanda , Lu Wei-En , Resende Rodrigo , Fernandes Gustavo Vicentis Oliveira
Published: January 2024

The goal was to assess dental students' perception of digital technologies after participating in a CAD/CAM exercise for scanning, designing, and manufacturing computer-aided provisional fixed dental restorations. A survey was conducted among second-year dental students (pre-D2 and post-D2), first- (D1, negative control), third-, and fourth-year dental students (D3 and D4, positive controls). Only OSU College of Dentistry students who completed the activity and completed the surveys were included. Seven questions were rated, which evaluated changes in knowledge, skill, interest, the importance of technology availability in an office, patients' perception of technology, the importance of having the technology, and the expected frequency of clinics utilizing the technology. Statistical analysis was performed with a significance level of 0.05. A total of 74 pre-D2 and 77 post-D2 questionnaires were completed. Additionally, 63 D1, 43 D3, and 39 D4 responded to the survey. Significant differences were found for "knowledge" and "skill" between pre-D2 and post-D2, and pre-D2 and control groups (p<0.001). There was a significant difference between post-D2 and all controls for “interest” (p=0.0127) and on practice preference for technology availability (p<0.05). There were significant results between post-D2 and all controls regarding the importance of technology availability in an office (p<0.001) and the expected frequency of clinics utilizing the technology (p=0.01). No significance was found for "patient's value of technology" and "the importance of having the technology". The presence of technology in the practice and educational academic environments significantly improved students’ interest and perception of knowledge and skill.