bluuebunny/crossref_metadata_2025 huggingface dataset:
Thyroid metastasis from nasopharyngeal cancer: a case report
Authors: Fatkullin D. M. , Guz A. O. , Garev A. V. , Zakharov A. S. , Sokolova M. I. , Shesler I. G. , Aristarkhova K. S.
Published: September 2023

Background. Nasopharyngeal cancer is a rare head and neck cancer with a relatively high risk of locoregional recurrence and distant metastases. The most common sites of metastases are bones (70–80 %) followed by liver (30 %), lung (18 %), and lymph node (axillary, mediastinal, pelvic, and inguinal). Thyroid gland is an uncommon site of metastasis with an incidence ranging from 0.5% to 24 %. Thyroid metastasis from nasopharyngeal cancer has been reported in only 9 cases in the world literature and no one in Russia. Case report. We report a case of thyroid metastasis from nasopharyngeal cancer found incidentally in a 53-year-old female patient. Conclusion. Metastases to the thyroid gland are rare, and patients with metastatic thyroid disease rarely present with organ-specifc symptoms, thus raising diagnostic diffculties for both clinicians and the pathologists. This clinical report demonstrates the diffculties of differential diagnosis,as well as the importance of a thorough collection of complaints, anamnesis, and clinical examination.
Dynamics of urinary kim-1 as a biomarker of acute kidney injury in cancer patients undergoing cisplatin-based chemotherapy
Authors: Sergeeva N. S. , Karmakova T. A. , Savchina V. V. , Deshkina T. I. , Karpenko E. Yu. , Bolotina L. V. , Alentov I. I. , Marshutina N. V. , Fedenko A. A.
Published: September 2023

Platinum is the main component of the most chemotherapy (CT) regimens, but their use may be limited because of nephrotoxicity. Kidney injury molecule 1 (KIM-1) is considered as an early marker of cisplatininduced acute kidney injury (AKI). The aim of our study was to evaluate the changes in the burinary levels of KIM-1 (uKIM-1) in cancer patients receiving nephrotoxic CT throughout the entire course of the treatment. Material and Methods. The level of uKIM-1 was determined by enzyme immunoassay in untreated 19 patients with solid malignancies before each CT cycle (regimens with cisplatin or oxaliplatin) and every next day after cytostatic drugs administration. uKIM-1 values were normalized to urinary creatinine concentration (uKIM-1). The kidneys function was assessed by the serum creatinine (sCr) and glomerular fltration rate (GFR) value. Results. According to laboratory parameters, renal function in patients before treatment corresponded to normal ranges. During CT, an increase in sCr by more than 50 % (decrease in GFR to 68 ml/min/1.73 m2 ), which corresponded to stage I AKI (KDIGO) was revealed in one patient (5.3 %) only. uKIM-1 levels before CT were above the upper limit of normal range (3.4 ng/mguCr) in 3 patients (15.8 %; median 2.1 ng/mguCr); at the beginning of the 2nd cycle of CT they were increased in 9 patients (47.4 %; median 3.2 ng/mguCr; p=0.0025, Mann-Whitney test); at the beginning of the 3rd cycle of CT uKIM-1 levels were increased in 12 patients (63.2 %; median 4.9 ng/mguCr; p=0.00007). During CT with cisplatin the average level of uKIM-1 increased with each subsequent cycle, in most cases it increased already the day after the administration of cytostatic drugs. No increase in uKIM-1 levels was observed during treatment with oxaliplatin-based regimens. The achievement of the threshold uKIM-1 level of 6.0 ng/mguCr at the beginning of the next cycle of CT was signifcantly associated with a high risk of its further increase (RR=18.8; p=0.0051). Conclusion. An increase in the level of uKIM-1 after cisplatin administration can be regarded as a marker of subclinical kidney damage. In the future, the increase in uKIM-1 level at the beginning of the cycle of CT may be a reason for enhanced preventive measures or the appointment of less nephrotoxic treatment regimens.
Phenotypic profle of monocyte-macrophage lineage cells as a function of respiratory epithelium status
Authors: Fedorov A. A. , Ermak N. A. , Topolnitskiy E. B. , Shefer N. A. , Rodionov E. O. , Pankova O. V. , Cherdyntseva N. V. , Stakheyeva M. N.
Published: September 2023

The mechanism of the relationship between pretumor changes in the bronchial respiratory epithelium and the risk of progression of non-small cell lung cancer (NSCLC) remains unclear. It has been suggested that the relationship between reactive changes in the bronchial mucosa and NSCLC progression may be caused by the functional status of monocytic-macrophage cells as important participants in infammation, which determines both the risk of premalignant changes in the epithelium and malignant progression. The purpose of the study was to investigate the phenotypic profle of peripheral blood monocytes and macrophages induced from monocytes in vitro depending on the state of respiratory epithelium in NSCLC patients. Material and Methods. The study included 39 patients with newly diagnosed NSCLC. Based on the morphological examination of small bronchi taken at the distance of 3–5 cm from the tumor, patients were divided into the following groups depending on the type of pretumor changes: no pretumor changes (n=6), isolated basal cell hyperplasia (BCH) (n=13), combination of BCH and squamous metaplasia (SM) (n=3), combination of unchanged epithelium and focal BCH (n=17). The phenotypic features of peripheral blood monocytes and in vitro-induced macrophages were assessed before treatment using fow cytometry. Results. The state of the respiratory epithelium in NSCLC patients prior to the start of anticancer treatment was associated with the phenotypic features of peripheral blood monocytes, but not with the profle of macrophages induced from them. Distortion of the response of induced macrophages to the polarizing stimuli was observed in NSCLC patients: the cultured cells responded to both M1 and M2 inducers (LPS and IL-4, respectively) with a phenotype shift to M2, while the CD206 marker expression varied depending on the presence and type of pretumor changes. Conclusion. The phenotypic profle of peripheral blood monocytes was associated with the state of the respiratory epithelium in NSCLC patients before anti-tumor treatment, but not with the phenotypic features of induced macrophages.
Cold ischemia during laparoscopic partial nephrectomy for a complex tumor (RENAL SCORE-11): a clinical case in one institute
Authors: Gaas M. Y. , Kaprin A. D. , Vorobyev N. V. , Inozemtsev R. O. , Rerberg A. G.
Published: September 2023

Background. Depending on the stage or location of the tumor, kidney resection or nephrectomy is the gold standard of treatment for renal cell carcinoma Preservation of organ function is essential for patients with localized tumors, especially with one kidney, chronic kidney disease, proteinuria, or multiple/bilateral masses. An important goal of kidney resection is to preserve the functional activity of the organ; however, the surgery leads to its decrease because of the loss of vascularized nephrons and irreversible ischemic damage. Description of the clinical case. A 24-year-old female was diagnosed with cT1bN0M0, Stage I right kidney cancer. An abdominal cavity and retroperitoneal MSCT with intravenous contrast showed a mass in the right kidney, extending into the renal sinus and causing pyelocalicoectasia. A laparoscopic resection of the right kidney was performed using the patented technique developed at the P.A. Herzen Moscow Oncology Research Institute and providing selective intra-arterial cold ischemia. This was prompted by the complex tumor anatomy, which indicated a prolonged kidney ischemia. Conclusion. Cold arterial perfusion has several advantages. First, it quickly cools the renal parenchyma to 25 °C, enabling faster and more comfortable kidney resection and suturing. Second, it eliminates the reverse venous blood fow caused by the positive perfusion pressure in the collecting system. Third, it does not imply the additional objects (for example, ice or clamps) in the work area, therefore not affecting the intraoperative view. The literature suggests hypothermia as the method of choice in most diffcult cases (resection of a single kidney, a large-diameter tumor, a high R.E.N.A.L. index).
Quantitative Soil Descriptions for Ecoregions of the United States
Authors: Shirazi Mostafa A. , Johnson Colleen Burch , Omernik James M. , White Denis , Haggerty Patricia K. , Griffith Glenn E.
Published: September 2023

Researchers have defined and mapped ecological regions of the United States based on similar patterns of ecosystems such as deserts, forests, and croplands. These studies are useful in regional research, monitoring, and environmental management because data can be more readily extrapolated within the same ecoregion and to regions with similar characteristics. The description of ecoregions is largely holistic and qualitative. Conversely, quantitative information for soil are abundant and soil is an important ecosystem component related to many ecoregion properties. We used the nationwide State Soil Geographic database (STATSGO) to describe the soils of 84 Level III ecoregions in the United States. Among the 24 soil characteristics studied were texture, rock fragments, available water capacity, bulk density, and organic matter content. For each ecoregion we developed ranks to describe (i) its similarity to the U.S. average soil characteristics, (ii) the accuracy of predicting those characteristics, (iii) how well the soil map unit boundaries fit within ecoregion boundaries, (iv) the spatial relationship of soils across neighboring ecoregion boundaries, and (v) the homogeneity of texture–rock patterns. We present a national map of soil texture and rock fragments and five soil ranks for each ecoregion, and examine relationships between soils and other ecological components for selected ecoregions. Because soils relate to other ecosystem components such as vegetation, geology, and land use, the soil ranks complement and enrich the qualitative ecoregion descriptions. Similar analyses of physical or biological components of ecoregions will expand the understanding of the ecosystem patterns.
WORK-RELATED MUSCULOSKELETAL DISORDERS AMONGNURSESOF GOVERNMENTAL HOSPITAL IN AL-MEDINAH, SAUDI ARABIA:A CROSS-SECTIONALSTUDY
Authors: F. Abualkhair Ahmed , M. Mansuri Farah , K. Aljarrah Mohammad , I. Alsharif Zahrah , S. Almohammedi Yasser , F. Abualkhair Eihab , B. Qarah Mohammed , A. Alzhrani Anas
Published: September 2023

Introduction: Work-related musculoskeletal disorders (WMSDs) considered to be one of the most common public health issues these days. Studies have addressed the issue of increasing prevalence of work-related musculoskeletal (MSK) pain among different occupations. However, contributing factors to MSK pain have not been fully investigated among Nurses. Thus, this study aimed to approximate the prevalence and predictors of MSK pain among the nurses working in governmental hospitals in Medina, Saudi Arabia. Methods: cross-sectional study took place on nurses of King Salman Medical city (KSAMC). The Standardized Nordic questionnaires for the analysis of musculoskeletal symptoms was utilized in our study. Results were analyzed descriptively using a Chi-square test and logistic regression analysis to estimate the odd ratio of experiencing disabling musculoskeletal symptoms. Results:Nearly 55% of the subjects were between ages 31 and 40 and 85% of the sample comprised of females. A multivariate logistic regression analysis revealed being a female nursesseem to have high odds and significant association with Neck pain OR = 5.5 (2.18-13.76, p<.001) Conclusion: Health care workers, particularly nurses, are at a heigh risk for work-related musculoskeletal disorders (WRMDs), and therefore, it is imperative that measures are taken to manage this global issue. Occupational therapists can play an integral role in this regard.
MENTAL DEPRESSION AS A RISK FACTOR FOR PERIODONTAL DISEASE
Authors: Tyagi Shilpi , Malhotra Sumit , Singh Mamta , Singh Sonali , Maheshwari R.
Published: September 2023

Periodontitis is a chronic, multifactorial, polymicrobial disease causing inflammation in the supporting structures of the teeth. There is a plethora of non oral risk factors which have been reported to aid in the development of chronic periodontitis. Psychological stress and depression have been documented to have a negative impact on the periodontal health. Depression is associated with negligent oral health care leading to poor periodontal health. Objective: The aim of this study was to assess the association between periodontal clinical parameters and depression. Methodology: The study design was a case-control study with 25 patients each in the Case and Control group. Case group consisted of patients diagnosed with depression by a specialist in the medical OPD. Control group consisted of the patients living in the same environment with similar background characteristics. All the cases and controls were assessed for the severity of depression by Hamilton Depression rating scale and Beck Depression Inventory. Periodontal parameters were assessed by using Oral Hygiene index Debris Index (DI) and Calculus Index (CI), Gingival Index, Probing Pocket Depth (PPD) and Clinical attachment loss (CAL). Results: In this study significant relationship is seen between subjects with depression and periodontal clinical parameters (DI, CI, GI, and PPD, CAL) as compared to the healthy subjects. Also it is seen that as the severity of depression increases, the periodontal condition deteriorates as reported by increased values of all the clinical parameters used in the study although, the relationship is not significant. Conclusion: After evaluating depression and periodontal clinical parameters we came to a conclusion that both diseases are related to each other and that stress or depression highly affects the periodontal health and therefore can be considered as a risk factor to periodontitis.
A REVIEW ON IMMUNOPATHOGENESIS OF VTILIGO
Authors:   Assistant Professor, Department Of Dermatology, Narayan Medical College and Hospital, Sasaram, Bihar, India., Alam Mahboob , Fatima Talat ,   Senior Resident, Department Of Dermatology, Nalanda Medical College and Hospital, Patna, Bihar, India.
Published: September 2023

Vitiligo is an acquired depigmenting disease of the skin and mucosa caused due to the destruction of the melanocytes. The white patch leads to social stigma in society and psychological stress in vitiligo patients. The etiopathogenesis of vitiligo is complex interplay of multiple genetic risk factors, environmental factors, neural factors, auto cytotoxicity, oxidative stress by reactive oxygen species, immunological factors, anti-melanocytes and organ-specific auto-antibodies mediated by autoreactive T lymphocytes in a genetically susceptible person. Hence, it is termed polygenic and multifactorial. All these factors, either alone or mixed leads to melanocytes death in a susceptible person leading to formation of depigmented patch. This review is an overview of the different pathomechanism involved in vitiligo.
UNCOVERING HIDDEN INSIGHTS: WHEN ABDOMINAL PAIN LEADS TO THE DISCOVERY OF RENAL INFARCTION
Authors:   Department of Emergency, Military Hospital University Mohammed V, Rabat, Morocco., H. Moussa Aicha , Mohamed Walid ,   Department of Emergency, Military Hospital University Mohammed V, Rabat, Morocco., Zidouh Saad ,   Department of Emergency, Military Hospital University Mohammed V, Rabat, Morocco., Belyamani Lahcen ,   Department of Emergency, Military Hospital University Mohammed V, Rabat, Morocco.
Published: September 2023

Renal infarction is a rare event that is often overlooked in emergency departments. Despite the contribution of imaging, diagnosis remains a delicate matterdue to the variety of clinical presentations. We describe a case of right flank pain revealing this entity.
IN VITRO ACTIVITY OF CEFTAZIDIME-AVIBACTAM AGAINST CARBAPENEM RESISTANT GRAM NEGATIVE ISOLATES
Authors:   Professor & HOD, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinavutapalli, Gannavaram Mandal, Krishna District, Andhra Pradesh, India., M.S.S Pradeep , N. Poojita ,   Tutor, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinavutapalli, Gannavaram Mandal, Krishna District, Andhra Pradesh, India., Kumar M. Giridhar ,   Associate Professor, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinavutapalli, Gannavaram Mandal, Krishna District, Andhra Pradesh, India., Babu Mekala Mahesh ,   Tutor, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinavutapalli, Gannavaram Mandal, Krishna District, Andhra Pradesh, India.
Published: September 2023

Introduction: Ceftazidime-Avibactam (CZA) is a Î²-lactam-Î²-lactamase inhibitor combination (BL/BLI) that has been given approval by the Food and Drug administration (FDA) for the treatment of different illnesses. However, resistance to Ceftazidime-Avibactam is developing in Carbapenem-resistant Enterobacteriaceae (CRE), Carbapenem-resistant Pseudomonas aeruginosa, and other Gram-negative bacteria, necessitating study of CZAs in vitro activity against these pathogens. Objective: To assess CZAs in vitro activity against CRE, carbapenem-resistant Pseudomonas aeruginosa, and other Gram-negative bacteria. Results: Of the 62 Carbapenem-resistant isolates obtained from various samples, Klebsiella pneumoniae accounted for 22 (35.48%), followed by Escherichia coli 21(33.87%), Pseudomonas aeruginosa 10(16.13%), Acinetobacter baumanii 7(11.30%), Citrobacter freundii 1(1.61%), and Proteus mirabilis 1 (1.61%) and the susceptibility rates against CZA showed Klebsiella pneumoniae-45.45% followed by E.coli-27.27%, Pseudomonas aeruginosa-18.18%, Citrobacter freundii-9.09% and the strains of A.baumanii and P.mirabilis were totally resistant to CZA. Conclusion: Even though CZA is regarded as an alternative form of treatment for infections caused by Carbapenem-resistant organisms (CRO), the higher resistance pattern at our center necessitates additional research involving numerous isolates and at different centers, where the results can be compared in order to ascertain the true prevalence of CZA resistance.
AN INSIGHT ON THE SUSCEPTIBILITY PATTERN OF URINARY ISOLATES OF ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE AGAINST FLUOROQUINOLONES WITH SPECIAL REFERENCE TO PRULIFLOXACIN
Authors:   Professor & HOD, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinavutapalli, Gannavaram Mandal, Krishna District, Andhra Pradesh, India., M.S.S Pradeep , T. Deepthi ,   Tutor, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinavutapalli, Gannavaram Mandal, Krishna District, Andhra Pradesh, India., Kumar M. Giridhar ,   Associate Professor, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinavutapalli, Gannavaram Mandal, Krishna District, Andhra Pradesh, India., Sri K. Shanti ,   Tutor, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinavutapalli, Gannavaram Mandal, Krishna District, Andhra Pradesh, India.
Published: September 2023

Introduction: The most prevalent infections in outpatient and inpatient settings are urinary tract infections (UTIs), which can be treated with a variety of antibiotics. Fluoroquinolones are the preferred antibiotic class and Prulifloxacin is one of these agents. It can be tested in vitro for its activity against urinary isolates of the bacteria Escherichia coli(E. coli) and Klebsiella pneumoniae (K. pneumoniae) for the purpose of surveillance, along with other fluoroquinolones. Objective: Evaluation of the fluoroquinolone susceptibility of urine isolates of K. pneumoniae and E. coli with a focus on Prulifloxacin. Results: 877 urine samples processed, 257 showed positive cultures, satisfying the Kass concept/Significant bacteriuria. Of these, 106 (41.2%) contained E. coli and K. pneumoniae, of which 92 (87%) were E. coli and 14 (13%) were K. pneumoniae. E. coli exhibited the highest susceptibility to Levofloxacin (61.9%), followed by Prulifloxacin (58.6%) where as to K. pneumoniae Levofloxacin (42.8%) and Prulifloxacin (50%). Conclusion: Levofloxacin is thought to be a drug reserved for the treatment of multi-drug resistant tuberculosis (MDR-TB), the study provides insight into the susceptibility patterns of urinary isolates of E. coli and K. pneumoniae against Prulifloxacin, which can be preferred as the drug of choice for the treatment of UTIs.
HABITABLE CONDITIONS REQUIRED FOR SPACE SETTLEMENT
Authors: Patra Kriti
Published: September 2023

Space habitats have been among the most discussed topics for decades. Many models have also been designed to sustain humanity in space. Among them are The Bernal sphere, The ONeill cylinder, and The Stanford Torus. The Stanford torus being the most acceptable model, designed the settlement as a torus located in the L5 point between the earth and the moon. By keeping the basic structure and location of the torus similar to it, a few structural changes have been suggested here, aiming to create better living conditions in the space habitat: dividing the torus into two and providing a general residential plan. Along with it, some other essential living criteria are also highlighted, such as the waste and water management systems.
LE SYNDROME DE MARCUS GUNN ISOLE : A PROPOS DUNCAS
Authors: Hmeimett Zeinebou , Kherchi Abdallah , Tabchi Manal , Boutimzine Nouridine , Ouafa Cherkaoui Lalla
Published: September 2023

Le syndrome de Marcus Gunn est une affection genetique, rare et detiopathogenie obscure. Il se traduit par la retraction de la paupiere superieure ptosee lors dun mouvement de la mÃ¢choire inferieure. Ce syndrome est du, probablement, a une innervation, erratique, du muscle releveur de la paupiere superieure, par les branches du trijumeau.
THE EFFECTIVENESS OF THE USE OF FOLDABLE STRATEGY IN SCIENCE INSTRUCTION
Authors:   National University Philippines., P. Pineda Girlie
Published: September 2023

Science deals with understanding terminologies, facts, and theories which on some learners might be intimidating. One way to solve this problem is to use strategies to help the learners understand the lesson better without compromising the learning process. Hence, the primary purpose of this experimental research study was to determine the effectiveness of the use of foldable strategy in science instruction to improve the academic performances and learning experiences of the students. The study utilized Randomized Pretest-Posttest Control Group, Using Matched Subjects Design. Data were gathered from 60 matched-sampled students. The data were analyzed utilizing independent t-test and paired t-test. Results of the t-tests showed that there were no statistically significant differences between the pre-test and post-test results of the control and experimental group. However, the experimental group had a higher mean of difference than the control group which indicates that the experimental group had gained more from the intervention.The results of the study were used to prepare an Outcomes-based Education (OBE) guide with the use of Foldable Strategy in Science Instruction. Recommendation made for the teachers was to continue using the traditional mode of teaching with the integration of Foldable Strategy to address higher order thinking skills of the students. Recommendations made for future researchers were to verify the results of the study using greater number of subjects in the control and experimental groups and by completing the four grading period or the whole school year as the length of the study.
JUDICIAL RECONSTRUCTION AND SUPPORT FOR THE INTERNATIONAL COMMERICAL ARBITRATION SYSTEM
Authors:   Doctoral Candidate, Faculty of Law, Krirk University, Thailand., Duan Zongyan , Yang Xiaopei ,   Doctoral Supervisor of Krirk University, Professor ofNanchang Vocational University, China.
Published: September 2023

The relationship between the judiciary and arbitration involves multiple dimensions. This article focuses on elucidating the procedural intersections between the judiciary and arbitration and the impact of the judiciary on arbitration. It emphasizes the bi-directional interactive nature of both systems aids in comprehensively analyzing their relationship, clarifying the respective scope and boundaries of arbitration and the judiciary, and conducting in-depth research on their interconnections in overlapping domains.
EFFECT OF ALUM AND PLANT EXTRACT AGAINST FOR BACTERIAL GROWTH
Authors:   Medical Microbiology / Department of Health Food and Nutrition/ College of Food Science /AL-Qasim Green University/Iraq., J.H AL-Hasseny Rabab
Published: September 2023

Identification VRSA isolate according to the most common quick test employed to identify the colonies of Staphylococcus aureus is the catalase test. This simple and invaluable test can differentiate Staphylococcus from Streptococcus. The oxidase test is another quick test that can differentiate Staphylococcus from Micrococcus. However, the VRSA was used on Vitc2 system that multidrug resistance.After solvent alum crystal in hot water 50% in concentration. Research effect the alum on VRSA strain and combination the alum with same plant after extraction. When used the well diffusion method the results were 2mm for each combined with peppermint (50%) and broad beans (50%) respectively compare in used the plant extracts which given 0.5mm in diameter for inhibition zone. But the alum aloene was 2mm in diameter. The potency result was the combination alum with aloe vera 3 mm in diameter for alum (50%) but the aloe vera was 0.5mm aloene.
Management of the Jatiluwih Irrigation area with sustainable planting patterns and water balance in Tabanan Regency
Authors: Triadi I Nyoman Sedana , Yasa I Made Tapa , Mudhina Made , Andayani Ketut Wiwin , Parwita I G L Made
Published: September 2023

Jatiluwih Village is located in Penebel District, Tabanan Regency, Bali. Jatiluwih Village is a highland village located at the foot of Mount Batukaru. This village is located at an altitude of 500-1500 meters above sea level and has an average rainfall of 2500 mm/year. Most of the population in the Jatiluwih area still relies on the economy of planting rice, with a good irrigation system. Rice fields in the Jatiluwih irrigation area need protection and preservation so that their area does not decrease. This priority is necessary because the meaning of land, including paddy fields is very important for humans, not only to own, but also to live their lives. Irrigation is an effort made to obtain water by using intake buildings and carrier channels. The Jatiluwih Irrigation Area has water sources from several springs that flow in the Jatiluwih Area. Jatiluwih weir with water sources from Tukad Baat has an irrigation area of 390 ha. The subaks that are irrigated by the Jatiluwih Dam are Jatiluwih Subak, Subak Gunungsari, Subak Kedamaian  and Subak Wangaya Betan. The development and management of irrigation networks will greatly assist water-using farmers in an effort to increase the production of agricultural products, especially rice.
AI Analysis of General Medicine in Japan: Present and Future Considerations (Preprint)
Authors: Aoki Nozomi , Miyagami Taiju , Saita Mizue , Naito Toshio
Published: September 2023

UNSTRUCTURED

This paper presents an interpretation of artificial intelligence (AI)–generated depictions of the present and future of general medicine in Japan. Using text inputs, the AI tool generated fictitious images based on neural network analyses. We believe that our study makes a significant contribution to the literature because the direction of general medicine in Japan has long been unclear, despite constant discussion. Our AI analysis shows that Japanese medicine is currently plagued by issues with polypharmacy, likely because of the aging patient population. Additionally, the analysis indicated a distressed female physician and evoked a sense of anxiety about the future of female physicians. It discusses whether the ability to encourage the success of female physicians is a turning point for the future of medicine in Japan.
Identification of Alzheimer Detection Using Hybrid Machine Learning Approach
Authors: Khade Laukik , Kotangale Hardik , Navale Girish , Bhise Dr. Archana
Published: September 2023

Abstract: Early detection of Alzheimer's is very important. The early and precise detection of Alzheimer’s disease-associated side effects and fundamental malady pathology by clinicians is essential for the screening, determination, and ensuing administration of Alzheimer’s illness patients. It moreover empowers patients and their caregivers to arrange for a long-standing time and make fitting way-of-life changes that might offer assistance to keep up their quality of life for longer. Tragically, recognizing early-stage Alzheimer’s illness in clinical hone can be challenging and is hindered by a few boundaries counting imperatives on clinicians’ time, trouble precisely diagnosing Alzheimer’s pathology, which patients and healthcare suppliers frequently expel indications as portion of the typical maturing prepare. As the predominance of this infection proceeds to develop, the current show for Alzheimer’s infection conclusion and persistent administration will be got to advance to coordinated care over clinical disciplines and the infection continuum, starting with essential care
Molecular Profiling and Data Analysis of Lung Adenocarcinoma
Authors: Das Madhura , Kumari Uma
Published: September 2023

Abstract: Lung adenocarcinoma, a major cause of cancer-related deaths globally, was examined through a comprehensive analysis of 230 resected tumors. This study integrated various sequencing techniques to profile messenger RNA, microRNA, and DNA, along with evaluating copy number variations, methylation patterns, and proteomic data. The findings revealed a notable rate of somatic mutations (average of 8.9 mutations per megabase). Among the 18 significantly mutated genes were RIT1 activating mutations and newly identified MGA loss-of-function mutations, which were mutually exclusive with MYC amplification. Gender-based differences were observed, with EGFR mutations being more common in females and RBM10 mutations in males. Genetic abnormalities in NF1, MET, ERBB2, and RIT1 were detected in 13% of cases, often in tumors lacking other activated oncogenes, suggesting their potential driver roles. Splicing alterations were driven by somatic genomic changes, as evidenced by DNA and mRNA sequencing from the same tumor, including MET mRNA exon 14 skipping in 4% of cases. While MAPK and PI(3)K pathway activity was explained by known mutations in some cases, unexplained mechanisms appeared to activate the pathways in others. These findings lay the groundwork for understanding lung adenocarcinoma’s molecular basis and offer insights for classification and further investigations. Molecular profiling is crucial for identifying actionable mutations, guiding treatment choices in advanced adenocarcinoma and acquired resistance to tyrosine kinase inhibitors. Circulating tumor DNA sequencing gains importance in NSCLC diagnostics due to its accessibility, allowing longitudinal disease monitoring. Notably, the overall cancer death rate dropped by 27% between 1991 and 2016, resulting in around 2,629,200 fewer expected cancer deaths compared to peak death rates.
Kajian Spasial Tingkat Kerentanan COVID-19 Di Kecamatan Pesanggrahan, Jakarta Selatan
Authors: Ramadhan Aditya , Mangapul Parlindungan Tambunan  , Rudy Parluhutan Tambunan
Published: September 2023

Pandemi COVID-19 di Jakarta mengalami lonjakan tinggi dikarenakan provinsi ini merupakan tingkat interaksi sosial yang tinggi, salah satunya di Kecamatan Pesanggrahan. Jakarta Selatan. Penelitian ini bertujuan mengidentifikasi dan menganalisa kerentanan penularan COVID-19 dari beragam parameter. Metode yang digunakan berbasis spasial berdasarkan klasifikasi yang telah dibuat dengan skoring dan pembobotan metode rangking berdasarkan enam variabel kerentanan fisik, sosial dan ekonomi. Selanjutnya, diintegrasikan Sistem Informasi Geografi untuk analisis overlay. Data penelitian menggunakan data sekunder yang berasal dari instansi terkait, sedangkan data primer diperoleh dari kegiatan langsung ke lapangan seperti melakukan penandaan lokasi dan dokumentasi. Penelitian ini menggunakan pendekatan kuantitatif deskriptif. Berdasarkan hasil penelitian diketahui bahwa Kelurahan Petukangan Utara dan Kelurahan Ulujami, seluruh wilayahnya terklasisfikasi kerentanan tinggi. Selanjutnya, Kelurahan Petukangan Selatan sebagian besar wilayahya memiliki kerentanan rendah namun terdapat wilayah dengan kerentanan sedang seluas ± 1,19 km². Kelurahan Bintaro seluruh wilayahnya memiliki kerentanan sedang ditambah sebagian kecil wilayah Kelurahan Pesanggrahan seluas ± 4,64 km² sedangkan sisanya terklasifikasi kerentanan rendah. Untuk kerentanan rendah secara keseluruhan terdapat pada Kelurahan Pesanggrahan dan Petukangan Selatan. Secara persentase keruangan Kecamatan Pesanggrahan, sebesar 20,88% luas wilayah memiliki kerentanan rendah, kerentanan sedang sebesar 43,33%, dan 35,8% terklasifikasi kerentanan tinggi.
Study of Groundwater Salinity Distribution in Coastal Areas, Adimulyo Sub-district, Kebumen Regency, Central Java
Authors: Winarno  , Agung Adiputra
Published: September 2023

Groundwater salinization occurs in Adimulyo Sub-district, Kebumen Regency due to human activities. A very slow river flow, due to its small hydraulic gradient towards the estuary area. Reduced groundwater due to increased uptake by human activities causes intrusive river water which results in brackish groundwater. The data analysis carried out in the study was based on the primary data of the sample whose groundwater salinity was measured, showing the influence of the salt solution at a certain level which indicates a level of salinity with a negative chloride ion content. The salinity value belongs to the type of brackish water. Electrical Conductivity Groundwater shows the nature of conducting electricity from water. The highest groundwater salinity is in the area of Adimulyo Sub-district, Kebumen Regency, the middle part, which ranges from 4.45 "° - 10.15 "°. There are other factors besides the distance of the area from the coastline, namely brackish river water (estuary), and the large amount of groundwater withdrawal by residents which can increase the absorption of brackish river water (estuary) into groundwater. In the northern part of Adimulyo Sub-district, Kebumen Regency is an area that has the lowest groundwater salinity, which ranges from 0.12 "° - 2.50 "°. As for the area of Adimulyo Sub-district, Kebumen Regency, the South has medium groundwater salinity, which ranges from 0.80 "° - 2.87 "°.
Potensi Gua Coban Perawan Dan Sekitarnya Untuk Menunjang Wisata Minat Khusus Di Kecamatan Gedangan Kabupaten Malang-Indonesia
Authors: Fatiya Rosyida  , Alfi Sahrina  , Yuswanti Ariani Wirahayu  , Akbar Wiguna  , Galih Fajar Sukoco  , Muhamad Fuad Chabib  , Mohammad Ainul Labib
Published: September 2023

Gua Coban Perawan berada pada Kawasan bentangalam karst di Desa Sidodadi Kecamatan Gedangan. Tujuan penelitian adalah 1). menganalisis sebaran kenampakan karst di sekitar Gua Coban Perawan; 2). menganalisis karakteristik gua-gua di sekitar Gua Coban Perawan; 3) melakukan pemetaan Gua Coban Perawan dan sekitarnya; dan 4) menganalisis aspek edukasi wisata Gua Coban Perawan dan sekitarnya. Penelitian ini dilakukan dengan melakukan survei lapangan, yaitu pengambilan kenampakan fitur karst dan survei bawah permukaan. Hasil survei lapangan digunakan untuk membuat peta gua dan analisis morfometri pada segmen lorong gua digunakan untuk melihat bentuk segmen lorong. Penggunaan software survex untuk membuat centerline gua dan penggunaan ArcGIS untuk membuat peta gua. Hasil inventarisasi gua memperlihatkan terdapat 15 gua yang berada di sekitar Gua Coban Perawan. Gua-gua tersebut memiliki karakteristik masing-masing. Gua Coban Perawan merupakan gua yang berada pada kawasan karst dengan bentukan yang unik. Gua Coban memiliki lorong horizontal, dan terdapat lorong vertical pada pintu masuk yang lain. Aliran masuk dan keluar menjadi penciri dari gua ini. Kondisi lorong gua yang di dominasi antara aliran air bawahtanah dan bongkahan batuan. Ornament gua berkembang pada gua ini. Selain Gua Coban Perawan, terdapat pula Gua Jenggot. Gua ini memiliki kemelimpahan ornament gua. Gua ini merupakan lorong kering dengan kondisi gua horizontal. Kedua Dengan adanya kenampakan yang ada di Gua Coban Perawan, dapat dijadikan sebagai wisata minat khusus berupa petualang dan edukasi. Edukasi wisata gua terkait keanekaragaman ornament gua, sungai bawahtanah, batuan penyusun berupa batugamping, biota gua, karakteristik lorong gua. Disamping itu, Gua Coban Perawan dan Gua jenggot dapat dijadikan sebagi blok wisata dengan memberikan beberapa wahana bermain bagi wisatawan.
Deteksi Perubahan Jalur Lahar di Curah Lengkong Pasca Erupsi Gunungapi Semeru 2021 Menggunakan Google Earth Engine
Authors: Azizah Vischawafiq , Listyo Yudha Irawan
Published: September 2023

Pemetaan jalur aliran lahar memiliki relevansi dengan bahaya vulkanik pasca-erupsi terjadi. Teknik penginderaan jauh semakin banyak digunakan untuk memetakan daerah gunungapi aktif, berkat kemampuannya untuk mensurvei area yang luas dan berbahaya dengan keterbatasan waktu dan biaya serta memiliki keakuratan resolusi spasial cukup tinggi. Tujuan dari penelitian ini adalah untuk mendeteksi perubahan jalur lahar pasca erupsi Gunungapi Semeru 2021 menggunakan klasifikasi terbimbing dengan Algoritma Random Forest dalam cloud computing Google Earth Engine. Data optik dan SAR merupakan sumber data pelengkap yang dapat digunakan untuk memetakan jalur aliran lahar secara efektif, selain mengurangi awan, dan meningkatkan kinerja pendeteksian perubahan. Sementara itu, studi area yang digunakan adalah Area of Interest (AOI) perubahan jalur aliran lahar di saluran Curah Lengkong yang masuk pada wilayah administrasi Desa Supiturang, Kecamatan Pronojiwo. Metode yang digunakan dalam penelitian ini adalah klasifikasi terbimbing dengan algoritma Random Forest berdasarkan platform Google Earth Engine (GEE) untuk menganalisis secara bersamaan citra yang diperoleh oleh Synthetic Aperture Radar (SAR) Sentinel-1, dan oleh sensor optik Sentinel-2 MSI. Hasilnya menunjukkan bahwa, meskipun beberapa piksel terisolasi salah diklasifikasikan sebagai dari jalur aliran lahar, pendekatan algoritma Random Forest dapat mengidentifikasi badan jalur aliran lahar utama dengan benar serta mencapai akurasi antara data training dan data uji serta validasi dominan melebihi >85% untuk OA dan Kappa >0.80. Artikel ini menyimpulkan bahwa teknik klasifikasi terbimbing dengan algoritma Random Forest dapat diaplikasikan untuk menganalisis data optik dan SAR sebagai upaya pemetaan perubahan jalur aliran lahar dengan jangkauan area yang luas dan berbahaya. Meskipun demikian, diperlukan proses pembuktian langsung ke lapangan untuk memvalidasi hasil pemetaan dan interpretasinya.
Analysis Of Landslide Susceptibility In The Cugenang New Fault Area In The North Of Cianjur Regency
Authors: Setiawan Hermawan , Wibowo Adi
Published: September 2023

A landslide is a disaster that often occurs in Indonesia, especially in morphology that has rough topography. This disaster is caused by faults, natural factors such as rainfall, topography, soil type, rock type, and human activity factors such as changes in land covered by a land cover or other factors related to landslide triggers. This research is located in the northern part of the Cianjur residency, this area is located between active volcanic mountains which have a distribution of sedimentary rocks and volcanic rocks, which are included in the Bandung physiographic zone, and have the new Cugenang fault. The unit of analysis is districts, which consist of 10 sub-districts. The purpose of this study was to analyze the landslide hazard distribution in the northern part of the Cianjur regency. The study used a sptial approach by using the weight overlay method for all parameters that have previously been analyzed and interpolated. The results of this study are very high Susceptibility covering 0.06%, high Susceptibility 47.49%, moderate Susceptibility 52%, and low Susceptibility 0.01%. The most vulnerable area is Sukaresmi, and the sub-district with moderate Susceptibility is Cikalong Kulon, while the low and high Susceptibility is relatively scattered in all areas with a small percentage. Based on the parameters analyzed, it means that rainfall and slope are the dominant driving factors in landslide Susceptibility in the northern part of the Cianjur regency because they have a large weight. This study provides a classification related to landslide susceptibility mapping in the northern part of Cianjur.
Pemetaan Daerah Potensi Longsor Menggunakan Analisis Fault Fracture Density Pada Data DEMNAS Di Wilayah Cisarua, Kabupaten Bandung Barat, Jawa Barat
Authors: Aliyan Silmi Afina , Totok Doyo Pamungkas  , Kusnahadi Susanto  , Putri Aprilia Ayesha
Published: September 2023

The Cisarua area is located in the northern part of Bandung City and is one of the sub-districts in West Bandung Regency and has steep topography in several locations, giving rise to the potential for landslides. The eastern region is part of the Lembang Fault which is still active in the North Bandung area. The potential for landslides related to the geological structure in this area can be identified by looking at the lineament patterns of the valleys, the presence of lithological offsets and others. The geological structure that developed in the Cisarua area was identified based on the results of analysis of satellite imagery data and the National Digital Elevation Model (DEMNAS) to identify the presence of geological structures and determine the direction of the dominant force. This study aims to determine the distribution of potential landslides in the Cisarua area using the Fault Fracture Density (FFD) method. Linearity analysis is estimated using the Fault Fracture Density (FFD) method. This method produces an analysis based on the straightness of the ridges and valleys around Cisarua which is then processed using a rosette diagram and interpreted as the dominant lineament trending west-east and northeast- southwest, this dominant lineament corresponds to the direction of the Lembang Fault. The lineament density level value describes a weak zone in the rock which creates the potential for landslide hazard. The weak zone in red indicates that the study area has a high landslide hazard potential, which is red, and the light green color indicates that the study area has a low landslide hazard potential. The potential for landslides in the study area is spread more in areas close to regional geological structures such as faults when compared to other areas. This pattern indicates that the presence of geological structures has an influence on the occurrence of landslides in potential areas.
La curcuma longa como anti-cancerígeno: Una revisión de la literatura
Authors: Pinzón Stefanía , Cabrera Lucía , Pico-Fonseca Sayda Milena
Published: September 2023

Introducción: Curcuma longa (cúrcuma) es una planta de origen hindú, compuesta principalmente por curcumina, entre sus múltiples atributos se le confiere propiedades antioxidantes, hipolipidémicas, antinflamatorias y anticancerígenas. Objetivo: Confirmar según la evidencia científica, si la cúrcuma posee propiedades anticancerígenas. Materiales y métodos: Se realizó una revisión bibliográfica en bases de datos como PubMed, MEDLINE y SciELO. El periodo comprendido para la revisión fue desde el primer semestre del 2006 hasta el primer semestre del 2018. Resultados: Se confirmaron características anticancerígenas en la curcumina, así como otros de sus beneficios en la inhibición del crecimiento tumoral y la acción de autofagia, la protección del daño oxidativo y su acción anti-proliferativa para la reducción en el desarrollo de células tumorales. Conclusión: Curcuma longa es útil en los procesos de prevención y tratamiento del cáncer; esto genera nuevos conocimientos y diversas aplicaciones en la lucha contra la enfermedad.
Docking Study, Synthesis, Characterization and Preliminary Cytotoxic Evaluation of New 1,3,4- Thiadiazole Derivatives
Authors: Mohammed Noor M. , Mohammed Mohammed Hassan , Abdulkhaleq Zainab M.
Published: September 2023

Objectives: This study has determined that these newly synthesized analogs hold promise as potential sources of novel anticancer agents for combating breast cancer.

Methods: We initiated our research by obtaining the crystal structure of Histone deacetylases (HDACs-8) bound with Vorinostat (SAHA) from the Protein Data Bank (PDB code 4QA0). Subsequently, we conducted docking experiments, which revealed that compounds (V c,s, V d,s, V c,t, and V d,t) exhibited favorable docking scores when compared to the standard. These compounds, synthesized through multi-step procedures involving the reaction of intermediate derivatives (IV c,d) with thiosemicarbazide or semicarbazide, were subjected to confirmation of their chemical structures using FT-IR and 1H NMR analysis.

Results: The results of our in-vitro cytotoxicity assay (MTT assay) highlighted that compounds V c,t and V d,t exhibited notable inhibition ratios in the breast cancer cell line (MCF-7), while V c,t displayed similar efficacy in human colon adenocarcinoma (HRT-18) compared to the control drug, Vorinostat (SAHA).

Conclusion: Our docking analysis led us to conclude that the C=S moiety demonstrated exceptional binding affinity to the zinc binding group of the HDAC enzyme, establishing multiple interaction modes. This finding suggests the potential of these compounds as valuable candidates in the development of anticancer treatments.
The Problem of the «Sovereign Internet» in Russia
Authors: Stepanov Sergey A. , Ivanova Ekaterina A.
Published: September 2023

The article is devoted to the problem of sovereignty of the Russian segment of the global Internet. The hypothesis of the study is that the Russian government intends to take control of the dissemination of information via the Internet, but this intention runs counter to the economic interests and objectives of the modernization of the country based on modern technologies. In this regard, the actions of the Russian authorities in this area are contradictory and half-hearted. Attempts to control the information space, social networks and video blogs are increasingly on the agenda in many states. At the dawn of its existence, the Russian segment of the Internet was practically free from censorship and from any interference from the state in general. Each user was free to express his personal opinion without fear of censorship. It should be recognized that complete freedom has not always been for the good. There were websites on the Runet that freely spread neo-Nazi, chauvinistic, xenophobic views. As the confl with the West deepened, the idea of protecting the Runet from hostile ideological infl following the example of China, was increasingly discussed in Russian government circles. Currently, the Runet, despite increased censorship, is still an integral part of the Internet. The fi part of the article is devoted to the analysis and comparison of the degree of control of social networks in diff countries and come to logical conclusions.