bluuebunny/crossref_metadata_2025 huggingface dataset:
THE POTENTIAL FOR GREEN ROOFS IN SUSTAINABLE URBAN DRAINAGE SYSTEMS
Authors: Davis M. J. M. , Tapia A. C.
Published: February 2020

Urban environments tend to lack the capacity to absorb water from precipitation. This is due to vegetated surfaces being replaced by impermeable ones, such as concrete, bitumen or similar. As a result problems can occur, where a period of heavy rainfall coincides with sudden increases in surface water runoff. This in turn can lead to a city’s sewerage system becoming overloaded. Sustainable Urban Drainage Systems (SUDS), are recognized worldwide as a successful manner by which to mitigate this phenomenon. One of the principal components of SUDS are permeable areas in an urban setting, which have the ability to absorb and retain rainfall that would otherwise flow as surface runoff. To date there has been little research into what the effect of a massive increase in green roofs would have for cities in Ecuador. As a developing country, it is not uncommon for cities’ sewerage systems to suffer collapse when faced with sudden rainfall peak loads. It is suggested in this paper, that instead of looking to implement costly sewerage expansion programs, it would be more cost effective to implement city scale green roof systems. The paper sets out to quantify the theoretical effect of such an initiative.
PERCEPTIONS OF THE CONSTRUCTION INDUSTRY
Authors: Minchin R. Edward , Close Shannon M. , Flood Ian
Published: February 2020

Despite the recent recession, the construction industry remains a vital part of the nation’s economy. As the current generation of workers grows older, the industry is beginning to face a lack of skilled workers. In addition to the growing need for workers, the industry has traditionally had a difficult time attracting younger workers to enlist in its trades due to stereotypes such as low wages and opportunities and the work taking place in a dirty and dangerous environment. The aim of this study was to determine and document the attitudes of post-high school adults about the construction industry. Understanding these attitudes could help construction companies and trade schools develop recruitment and training programs that attract younger workers to the industry. A survey was conducted and the respondents’ answers were analyzed statistically in order to determine general attitudes, differences in attitudes within the population, and differences between their attitudes and opinions and those of high school students. The results of the study show that many of the traditional stereotypes connected with construction, such as a dirty work environment, still exist. However, post-high school adults are increasingly aware of the opportunities and competitive wages available in construction-related jobs. Significant differences in responses were also found within the populations when looking at gender, age, and education level. Lastly, post-high school adults were found to have more favorable opinions of the construction industry than students in high school.
FREQUENTLY OCCURRING LOSSES OF PRODUCTIVITY IN THE SHELL CONSTRUCTION PHASE
Authors: Kummer Markus , Hofstadler Christian
Published: February 2020

In construction projects, losses of productivity often lead to additional costs and time delays. Suboptimal working conditions influence the labor productivity of workers and have an effect on the number of working hours required, for instance, to produce one cubic meter of reinforced concrete. Costs can be reduced and total productivity increased if the sources of potential losses of productivity are identified at the process planning stage or in early project phases. An expert survey conducted in 2014/2015 at Graz University of Technology, Austria, collected data on the losses of productivity that most frequently occurred in conjunction with reinforced concrete works in the shell construction phase. A standardized questionnaire was used for this survey. In addition, an interview was held with each of the experts to discuss the questionnaire in order to improve the quality of the survey and to gather important background information that prompted the responses provided by the experts. For this survey, reinforced concrete works were divided into ramp-up, main construction and final phases. Experts from Austria and Germany were able to select from a range of predefined losses of productivity and to specify other losses separately. This paper reports on the progress of the survey and refers to the related analytical methods. Furthermore, findings of the expert survey are represented in bar diagrams and interpreted. The survey revealed that the main construction phase was generally associated with the greatest potential for losses of productivity. Furthermore, most frequently stated losses of productivity varied depending on the specific construction phase. Future construction projects should particularly focus on the losses of productivity that were most frequently mentioned in the expert survey. The benefit of this approach is that it will provide the opportunity to implement early compensatory measures and to minimize the potential for losses of productivity.
DEMOTIVATING FACTORS FOR ARCHITECTS IN THE CONSTRUCTION INDUSTRY
Authors: Gümüşburun Ayalp Gülden , Arslan Fatma
Published: February 2020

Motivation is one of the factors that influence the productivity of people. Architects play a vital role in the management of projects in the construction industry. The success of construction projects relies heavily on their active involvement and effective performance. Hence it is important to assess the impact of motivation on the performance these architects. On the other hand, architects are frequently confronted with problems that could lead them to demotivation. Demotivation is caused not simply by a lack of motivators but the existence of certain situations that cause dissatisfaction and discourage individuals from pursuing desired goals and aims. From this point of view, the present study conducted with the aim of identifying factors affecting demotivation of Turkish architects. After a review of extant literatures in construction management, and design management 69 demotivating criteria was produced and used in questionnaire survey, and data were collected from architects who are working at construction industry, especially at design firms. The questionnaires were administered to architects via e-mail, and 71 participants responded to the survey. Utilizing the particular statistical analyzes, the factors were identified for detailed analysis and discussion. From the findings of the present study, ten underlying demotivating factors have been identified for architects in Turkish construction industry. This study would help managers of design firms to develop healthy workforce through eradication of the identified demotivating factors using some of suggested solutions.
BEHAVIOR OF HYBRID STEEL FIBER REINFORCED HIGH STRENGTH CONCRETE
Authors: Balanji Emdad K. Z. , Sheikh M. Neaz , Hadi Muhammad N. S.
Published: February 2020

High strength concrete has higher strength but lower ductility. Inclusion of single type of fibers into concrete has been proven to improve the behavior of concrete to a limited extent. However, recently it was found that the behavior of concrete can be improved more with the addition of hybrid fiber i.e., a combination of different types of fiber. This paper presents the results of an experimental investigation on the behavior of Hybrid Steel Fibre Reinforced High Strength Concrete (HSFR-HSC). A total of eight cylinder specimens with 150 mm in diameter and 300 mm in height were cast and tested under uniaxial compression. Three different combinations of HSFR-HSC specimens and reference specimens without steel fibers were prepared. The first combination of HSFR-HSC included 1.5% Micro Steel (MS) fibers and 1% Deformed Steel (DS) fibers. The second combination included 1.5% MS fibers and 1.5% Hooked-end Steel (HS) fibers. The third combination included 1% DS fibers and 1.5% HS fibers. The experimental results showed that the addition of hybrid steel fibers improved the strength and ductility of high strength concrete compared to the reference specimens. The results also showed that the specimens reinforced with different hybrid steel fibers failed in a ductile manner, while the reference specimens failed in a brittle manner.
CURRENT STATE OF PRACTICE IN DISASTER RISK MANAGEMENT
Authors: Mlybari Ehab , Ahmed Imtiaz , Khalil Muhammad
Published: February 2020

The Kingdom of Saudi Arabia has historic profile of multifaceted disasters, including, floods, earthquakes, volcanoes, cyclones, sand storms, rock falls, collapse of structures, epidemics, fire, terrorist acts, stampedes and other complex emergencies. The recurring enormous human and material losses emphasize the need for pursuing modern concept and approach which entail paradigm shift in handling disasters, from 'response centric' to 'proactive' disaster risk management (DRM) leading to disasterresilient infrastructure, building integrated response capability and achieving enhanced awareness in the societal context. The DRM encompasses all activities related to disaster mitigation, preparedness, emergency response, recovery, rehabilitation and reconstruction. The study synthesizes information obtained on DRM from published literature, personal experiences and interaction with the stakeholders. Besides, questionnaire survey was also conducted to assess the community awareness and preparedness of concerned departments. The study undertakes comprehensive review of KSA disaster profile, current practices, response capability and human resource development. It has been identified that KSA is confronting multifaceted challenges including, lack of formal training and professional expertise; lack of understanding about conceptual aspects of disasters and coordination amongst various stakeholders; and absence of hazard risk assessment, mapping or micro-zoning, building codes, etc. This paper gives KSA sate of practices, institutional mechanism and capacity building needs to manage disasters on integrated and sustainable basis.
USE OF THE HOLE DRILLING METHOD TO DETERMINE RESIDUAL WELD STRESSES IN BRIDGE CONSTRUCTIONS
Authors: Puymbroeck Evy Van , Nagy Wim , De Backer Hans
Published: February 2020

Complex welding operations in orthotropic steel bridge decks introduce residual stresses near the weld region. To estimate fatigue failure of this type of bridge deck, tensile residual yield stresses are usually assumed around the weld region. However, to estimate the residual stress distribution near a weld connection more precisely, a test setup is developed. The weld connection of a closed longitudinal trapezoidal stiffener with the deck plate of an orthotropic bridge deck is investigated. The incremental hole-drilling technique is used to measure the residual stresses with strain gauge rosettes. Strain gauge rosettes are positioned on the deck plate and on a longitudinal stiffener of the orthotropic steel deck. A small hole is drilled through the center of the strain gauge rosettes and strains are measured at incremental depths. The residual stresses are calculated and based on these experimental measurements a distribution of the residual stresses is obtained. Compressive residual stresses exist near the longitudinal stiffener-to-deck plate weld. On the deck plate, the compressive residual stresses are equal to 60% of the yield strength while the compressive residual stresses on the stiffener are 42% of the yield strength. There are tensile residual stresses on both sides of the weld region. However, more research is necessary to confirm this distribution since it is contradictory to expected stresses in literature.
PERFORMANCE OF HIGH STRENGTH CONCRETE COLUMNS REINFORCED WITH HYBRID STEEL FIBER UNDER DIFFERENT LOADING CONDITIONS
Authors: Balanji Emdad K.Z. , Sheikh M. Neaz , Hadi Muhammad N.S.
Published: February 2020

The strength and ductility of high strength concrete columns improve with the addition of steel fiber. This paper reports the behavior of circular High Strength Concrete (HSC) columns reinforced with Hybrid Steel Fibers (HSF) under different loading conditions. In this study, HSF consisted of a combination of macro steel fibers and micro steel fibers. A total of eight circular specimens of 205 mm diameter and 800 mm height were cast and tested. All specimens were reinforced with same amount of steel reinforcements. The specimens were divided into two groups of four specimens. Group RC (reference group) contained no steel fibers. Group HSF (hybrid steel fibers) contained 2.5% by volume of HSF. From each group one specimen was tested under concentric loading, one under 25 mm eccentric loading, one under 50 mm eccentric loading, and one under four-point loading. The results showed that the specimens reinforced with HSF achieved higher strength and ductility compared to RC specimens under different loading conditions. It was also observed that the presence of HSF delayed the spalling of the concrete cover.
THE EFFECT OF REINFORCING ARRANGEMENT ON THE BEHAVIOR OF REINFORCED CONCRETE FLANGED DEEP BEAMS WITH WEB OPENINGS
Authors: Ali Abbas Hilo
Published: February 2020

The objective of the work is to investigate the structural behavior of reinforced concrete flanged deep beams with web openings under repeated loading through experimental tests which were carried out on simply supported T-beams , subject to two point loads. This work deals with the results of experimental work with three test specimens with square opening 25% of web depth at mid high through critical shear path. The effect of steel reinforcement arrangement for web opening is investigated. The experimental tests of sections under repeated loading showed that reinforcement of web opening increased the cracking and ultimate loads. It is observed that reinforcement for opening reduced the deflection and the crack width. The inclined reinforcement results are better than orthogonal.
STRENGTHENING OF PRESTRESSED HOLLOW CORE SLABS WITH OPENINGS USING NSM-CFRP STRIPS
Authors: Mahmoud Karam , Foubert Steven , El-Salakawy Ehab
Published: February 2020

Precast, prestressed, hollow-core (HC) slabs are extensively used in many structures such as parking garages, commercial and industrial buildings. It is common for such structures to undergo changes while still in service, which may result in a reduction of their strength. One of these changes is to add in-situ openings at different locations along the slab to accommodate services such as intake/exhaust ducts or utility conduits. Near surface mounted (NSM) strengthening technique has proved to be an adequate technique that can be employed to restore or enhance the performance of the original structure. In this paper, the effect of openings and the efficiency of using NSM carbon fiber reinforced polymer (CFRP) strips as strengthening technique are investigated. A total of three full-scale prestressed HC slabs were tested; one without opening, one with an opening in the pure flexural zone and one with strengthened opening. Test results showed the presence of opening along the flexure span had a significant adverse effect on the post-cracking flexural stiffness, cracking load and the ultimate capacity of the slab. However, strengthening the opening with two strips of NSM-CFRP effectively enhanced the post-cracking stiffness, increased the ductility of the member and restored the flexural strength deficit incurred as a result of cutting the opening, and provided a net increase in flexural capacity.
A história da ciência em libros didáticos do 5° ano do ensino fundamental no Brasil e em Taiwan
Authors: Rodio Saucedo Kellys Regina , Chen Miao Shen , Wendling Cleria Maria , Malacarne Vilmar
Published: February 2020

La presente investigación comprende el análisis de contenidos de Historia de la Ciencia en libros didácticos de Ciencias Naturales utilizados en escuelas de Enseñanza Fundamental y años iniciales. En concreto, se constituyeron  como objeto de estudio los libros didácticos del 5º año seleccionados –por los municipios de Cascavel, Paraná (BR) y de Kaohsiung (高雄), Taiwán (台灣)– para uso en las aulas. En el caso de los libros de texto, se basan en las siguientes problemáticas: "¿cuáles son los contenidos de Historia de las Ciencias y cómo se abordan en estos libros didácticos?". Y, basados en el instrumento analítico, elaborado por Laurinda Leite, procedemos a la argumentación acerca de tres dimensiones categóricas: tipo y organización de la información histórica; propuestas de actividades que involucran la Historia de la Ciencia; y el estado del contenido histórico. Los resultados, emanados de la investigación cualitativa de los libros nacionales e internacionales, indicaron la presencia de contenidos sobre la Historia de las Ciencias en todos los libros analizados. Teniendo, sin embargo, especificidades en cuanto a la presentación de esos contenidos. En el estudio fue posible todavía plantear consideraciones sobre el potencial de los estudios comparativos para la comprensión de las concepciones sobre la enseñanza de la Ciencia aplicada en esos países.
HUBUNGAN SPASIAL TRANSAKSI TANAH DENGAN PERKEMBANGAN WILAYAH DI KABUPATEN CIREBON, JAWA BARAT
Authors: Marzuki Amin , Sitorus Santun Risma Pandapotan , Soma Soekmana
Published: February 2020

The big potential of Cirebon Regency with good transportation access and demography bonus is able to promote its regional development. Not all of the potential has been optimized to invite investment in Cirebon Regency. One of the causes is some of the lands haven't been registered, so that obstructs investment that requires land. We explore the spatial relationship between the regional development level and land transaction pattern. We calculate the entropy diversification index to see the level of regional development. We also interpolate the land transaction to see the spatial pattern. The natural neighbor interpolation method was used to show spatial patterns of land transactions. Then, we overlay the map of the entropy index and land transaction pattern map to see the relationship spatially. Land transactions in Cirebon Regency gathered in a very developed and developing region. Districts of Palimanan, Depok, Plumbon, Weru, and Plered that are categorized very developed have more quantity of transactions and land transaction value than the undeveloped area. Pasaleman district has Kecamatan Depok, has the smallest entropy index, and categorized as undeveloped has a lower number and value of land transactions. We found a similar spatial pattern between the regional level of development and land transaction interpolation.
SELF-NARRATIVES OF BRAZILIAN DEAF PEOPLE: APPLICATION OF THE HYPOTHESES OF SOCIOANALYSES
Authors: PEDROSA CLEIDE EMILIA FAYE
Published: February 2020

The objective of the study is to apply eight hypotheses of the socioanalysis for the interpretation and critical social reading of the "self-narratives" of deaf applicants to Higher Education at the Federal University of Sergipe (UFS-Brazil). It is located in the theoretical-methodological field of Critical Discourse Analysis  (CDA), and Deaf Studies (DS). We will analyze a narrative of a deaf subject, corpus collected in 2014, in the college entrance examination for the Brazilian Sign Language Course (LIBRAS), and adopt this methodological guideline, to define object of study;  identify areas of interfaces that meet the objectives; select the categories of each area of interface; establish the dialogue between categories;  identify the social meanings constructed in the discourse. The result confirms the role of socioanalysis in seeking to unveil how the practice of social relations and (re)construction of their identities in the struggle for citizenship rights articulate in the deaf individual's life.
THE DIALECTICS OF ENGLISH DOMINANCE
Authors: MONZO LILIA D.
Published: February 2020

The Hegemony of English across the world cannot be overstated (Macedo, Dendrinos & Gounari 2016). More and more nations are encouraging, if not mandating through compulsory education requirements, that their citizens learn English (Xue & Zuo 2013). This demand for English is rising even among countries who have few native speakers of English. Importantly, making any language learning a national project carries a critical message about that language and its power. Robert Philipson (2011) points out that this growing demand and compulsory establishment of English (through schooling) can be nothing less than linguistic imperialism, with the World Bank re-introducing the historical colonial order. Nations are clamoring to learn English as quickly as possible in the hopes that doing so will boost their competitive edge on the global market (McCormick 2013). Indeed, there is evidence that English proficiency elevates the status and power of specific nations and provides individuals greater access to jobs and resources, but as Anna Odrowaz-Coates shows, in the case of Portugal and Poland, this will not happen without a significant cost to the national identity and to the identities of the people and their families and communities.
Composition, Anticholinesterase and Antipedicular Activities of Satureja capitata L. Volatile Oil
Authors: Jaradat Nidal , Adwan Lina , Zaid Abdel Naser , K’aibni Shadi , Arar Mohammad
Published: February 2020

The emergence of resistance for antipedicular agents and the need of potent acetylcholinesterase (AChE) therapeutics for the treatment of a neurodegenerative disorder such as Alzheimer disease has led researchers to the exploration of new therapeutic alternatives such as natural volatile oils. Therefore, the current investigation aimed to identify the components of Satureja capitata L. volatile oil (VO), and examine the VO anticholinesterase, and antipedicular activities. The plant phytoconstituents were identified using Gas chromatography mass spectrometry (GC-MS) method, while the anticholinesterase activity was determined against butyryl- and acetyl-cholinesterase using Ellman’s method. In addition, antipedicular activity was established using the diffusion method. The obtained GC-MS results identified 16 compounds in S. capitata VO with the major constituents being carvacrol, γ-terpinene, and p-cymene. Anticholinesterase analysis showed a marked inhibition potential against acetyl- and butyryl-cholinesterase enzymes with half maximal inhibitory concentration (IC50) values of 28.24±0.97 μg/ml and 92.31±1.22 μg/ml, respectively in comparison with the reference compound galantamine, which has IC50 values against the same enzymes of 5.21±0.07 μg/ml and 10.33±0.37 μg/ml, respectively. In addition, the VO, at a concentration of 20%, was effective against head lice, similar to benzyl benzoate, which resulted in 100% mortality. In addition, the VO completely inhibited the emergence of lice nits after 6 and 14 days. On the basis of the obtained results, S. capitata VO is a promising natural alternative to synthetic antipedicular and anticholinesterase drugs, which can be employed in drug development, and may lead to new candidates against head lice and neurodegenerative diseases.
A characterization of real holomorphic chains and applications in representing homology classes by algebraic cycles
Authors: Teh Jyh-Haur , Yang Chin-Jui
Published: February 2020

We show that a 2k-current T on a complex manifold is a real holomorphic k-chain if and only if T is locally real rectifiable, d-closed and has ℋ2k-locally finite support. This result is applied to study homology classes represented by algebraic cycles.
The Use of Logic Regression in Epidemiologic Studies to Investigate Multiple Binary Exposures: An Example of Occupation History and Amyotrophic Lateral Sclerosis
Authors: Bellavia Andrea , Rotem Ran S. , Dickerson Aisha S. , Hansen Johnni , Gredal Ole , Weisskopf Marc G.
Published: February 2020

Investigating the joint exposure to several risk factors is becoming a key component of epidemiologic studies. Individuals are exposed to multiple factors, often simultaneously, and evaluating patterns of exposures and high-dimension interactions may allow for a better understanding of health risks at the individual level. When jointly evaluating high-dimensional exposures, common statistical methods should be integrated with machine learning techniques that may better account for complex settings. Among these, Logic regression was developed to investigate a large number of binary exposures as they relate to a given outcome. This method may be of interest in several public health settings, yet has never been presented to an epidemiologic audience. In this paper, we review and discuss Logic regression as a potential tool for epidemiological studies, using an example of occupation history (68 binary exposures of primary occupations) and amyotrophic lateral sclerosis in a population-based Danish cohort. Logic regression identifies predictors that are Boolean combinations of the original (binary) exposures, fully operating within the regression framework of interest (e. g. linear, logistic). Combinations of exposures are graphically presented as Logic trees, and techniques for selecting the best Logic model are available and of high importance. While highlighting several advantages of the method, we also discuss specific drawbacks and practical issues that should be considered when using Logic regression in population-based studies. With this paper, we encourage researchers to explore the use of machine learning techniques when evaluating large-dimensional epidemiologic data, as well as advocate the need of further methodological work in the area.
The crystal structure of a matrine derivative, 13-(methylamine-1-yl) carbodithioate matrine, C17H27N3OS2
Authors: Hui-Qing He , Fang-Yun Dong , Han-Hui Zhang , Jing-Min Ye , Chun-Can Tan , Xu-Hong Jiang , Zi-Zhao Zheng , Xiao-Jing Lv , Xing-An Cheng
Published: February 2020

C17H27N3OS2, monoclinic, P21 (no. 4), a = 8.8052(10) Å, b = 10.8860(10) Å, c = 18.6705(2) Å, β = 99.2730(10)°, V = 1766.24(3) Å3, Z = 4, Rgt
(F) = 0.0298, wR
ref(F
2) = 0.0802, T = 100.00(10) K.
One state that emerged from others. The image of Polish-Lithuanian Commonwealth in Alessandro Guagnini’s writings
Authors: Gis Kacper
Published: February 2020

Research concerning the history of government and administration should be based not only on historical documents (like legal acts) but also narrative or literary sources such as chronicles. These texts contain large amounts of information about old forms of administration. A good example of that kind of narrative source is the description of European Sarmatia written by Alessandro Guagnini. The author of this text was Italian, who lived in the Polish-Lithuanian Commonwealth at the turn of sixteenth and seventeenth century. This text was a historical and geographical relation about the Polish-Lithuanian Commonwealth and its neighbours. It was reprinted in different editions and in few languages having a considerable impact on a perception of abovementioned state and even Central and Eastern Europe as well.

In modern times Guagnini’s works have been quite forgotten, nevertheless its renewed analysis leads to interesting information at various levels. One of them is presentation of government model in the Polish-Lithuanian Commonwealth. The described state consisted of few great regions each of which had its own administrative division, history and customs. Together they merged into a great political entity ruled by one monarch and approaching unification.

The purpose of this article is to present administrative division in the pages of the described chronicle and how that division was ideologically legitimated by appealing to ancient Sarmatia.
Mergers and acquisitions in Greece
Authors: Czarnota Zbyszko
Published: February 2020

The financial crisis has paradoxically protected many sectors of the Greek economy from collapse. The ownership structure of companies in Greece was dominated by state and local government companies. Private companies have not only contributed capital and protected employees from unemployment, but have also given a new organisational culture to companies.
Explorations of Engagement: Introduction
Authors: Bergqvist Henrik , Knuchel Dominique
Published: February 2020

The paper explores engagement as a linguistic category by discussing its defining characteristics. Following work by Evans and colleagues (2018a, b), we discuss issues of scope and the intersubjective distribution of information, as central to the definition of engagement. In addition, we examine the notion of access as a crucial component of engagement marking and we attempt to distinguish access from epistemic authority, which we argue is a prerequisite for the existence of engagement as a linguistic category. Both access and epistemic authority appear central to an analysis of engagement marking, as found in the literature and in the languages of this Special Issue. From an interactional point of view, engagement may be viewed as a form of “stance” (Du Bois 2007), in that it primarily positions the speech participants with respect to talked about events from the point of view of the speaker.
ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability
Authors: Busti Irene , Allegra Manuela , Spalletti Cristina , Panzi Chiara , Restani Laura , Billuart Pierre , Caleo Matteo
Published: February 2020

Oligophrenin-1 (Ophn1) encodes a Rho GTPase activating protein whose mutations cause X-linked intellectual disability (XLID) in humans. Loss of function of Ophn1 leads to impairments in the maturation and function of excitatory and inhibitory synapses, causing deficits in synaptic structure, function and plasticity. Epilepsy is a frequent comorbidity in patients with Ophn1-dependent XLID, but the cellular bases of hyperexcitability are poorly understood. Here we report that male mice knock-out (KO) for Ophn1 display hippocampal epileptiform alterations, which are associated with changes in parvalbumin-, somatostatin- and neuropeptide Y-positive interneurons. Because loss of function of Ophn1 is related to enhanced activity of Rho-associated protein kinase (ROCK) and protein kinase A (PKA), we attempted to rescue Ophn1-dependent pathological phenotypes by treatment with the ROCK/PKA inhibitor fasudil. While acute administration of fasudil had no impact on seizure activity, seven weeks of treatment in adulthood were able to correct electrographic, neuroanatomical and synaptic alterations of Ophn1 deficient mice. These data demonstrate that hyperexcitability and the associated changes in GABAergic markers can be rescued at the adult stage in Ophn1-dependent XLID through ROCK/PKA inhibition.

SIGNIFICANCE STATEMENTIn this study we demonstrate enhanced seizure propensity and impairments in hippocampal GABAergic circuitry in Ophn1 mouse model of X-linked intellectual disability (XLID). Importantly, the enhanced susceptibility to seizures, accompanied by an alteration of GABAergic markers were rescued by Rho-associated protein kinase (ROCK)/protein kinase A (PKA) inhibitor fasudil, a drug already tested on humans. Because seizures can significantly impact the quality of life of XLID patients, the present data suggest a potential therapeutic pathway to correct alterations in GABAergic networks and dampen pathological hyperexcitability in adults with XLID.
Democratizing CRISPR? Stories, practices, and politics of science and governance on the agricultural gene editing frontier
Authors: Montenegro de Wit Maywa
Published: February 2020

Many trends in agricultural biotechnology have extended fluidly from the first era of genetic modification using recombinant DNA techniques to the era of gene editing. But the high-profile, explicit, and assertive discourse of democratization with gene editing — especially CRISPR-Cas9 — is something new. In this paper, I draw on semi-structured interviews with gene editors, policy analysts, and communications experts as well as with critical academic and civil society experts. I use Science and Technology Studies and political ecology lenses to unpack democratization in three main parts. First is democratizing discourses: On what grounds is CRISPR said to be democratic? Who is saying so? How do dissident communities respond to these narratives? Second is agricultural applications, with a focus on the Innovative Genomics Institute’s work in developing gene-edited food crops, including a case of saveable clonal hybrid rice. Third is governance, where I contrast US Department of Agriculture regulations and the CRISPRcon conference as “closed” and “invited” spaces, respectively, for democratic participation. Next, I argue that “created spaces,” in which power is held by typically delegitimized actors and ideas, offer an opening for working out democracy on the terrain of biotechnology. I conclude with a set of principles and practices for CRISPR governance based on the idea that democratization of biotechnology requires epistemic justice. By gathering multiple, partial knowledges together, we move beyond narrow risk-benefit framings to better evaluate not just what CRISPR is and does, but what democracy means and whom it serves.
Генеза наукових підходів до дефініції “здоров’язбереження”
Authors: Medynskyi Serhii , Karvatska Yuliia
Published: February 2020

У статті аналізуються підходи до визначення поняття “здоров’язбереження”, що поєднують у собі всі сфери соціального життя пов’язані із захистом, збереженням, формуванням та зміцненням здоров’я громадян держави. Актуальність дослідження пояснюється значенням “здоров’язбереження” в розв’язанні соціально значущої проблеми охорони здоров’я особистості через залучення до здорового способу життя; великим потоком педагогічних досліджень в цій області; необхідністю приведення в систему розрізнених теоретичних знань. Виявлення особливостей окремих теорій необхідно для їх подальшого розвитку та впровадження в практику, для забезпечення наступності теоретичних досліджень. Досліджено, що здоров’язбереження формує поведінку, охоплює цілісну систему ціннісно-смислових установок, емоційно-вольового досвіду, спрямована на самопізнання, саморозвиток і самовдосконалення індивідуального здоров’я, базується на готовності до практичної діяльності по збереженню здоров’я.
Програми раннього вступу до університетів та коледжів для обдарованих старшокласників у США
Authors: Tadeieva Mariia , Tadeiev Petro
Published: February 2020

У статті досліджено програми раннього вступу до університетів та коледжів для обдарованих старшокласників у США. Схарактеризовано спеціальні програми для обдаро-ваних старшокласників, які в своєму інтелектуальному, емоційному та особистісному розвитку на декілька років випереджають ровесників. Доведено, що всі програми раннього вступу до університетів у різних штатах базуються на стратегіях прискореного і збагаченого навчання; виокремлено організаційні відмінності такого навчання у різних штатах. Проаналізовано сутність таких програм раннього вступу, як Міжнародний Бакалаврат, академічні олімпіади й конкурси, літні школи, волонтерські програми, тощо. Авторами окреслено шляхи імплементації американського досвіду раннього вступу до закладів вищої освіти в Україні.
Критерії, показники та рівні розвитку комунікативної компетентності офіцерів-прикордонників в умовах магістратури
Authors: Zavydovych Victoriia
Published: February 2020

Проблема розвитку комунікативної компетентності як основи взаєморозуміння і взаємодії сьогодні набуває все більшої актуальності. Особливі вимоги до володіння означено юкомпетентністю висуваються до офіцерів-прикордонників. У статті висвітлено та обґрунтовано наукові підходи у з’ясуванні критеріїв, показників і рівнів розвитку досліджуваного феномена. Визначено такі критерії: мотиваційний, когнітивний, діяльнісний, які безпосередньо співвідносяться зі структурними компонентами. Для вказаних критеріїв установлені відповідні показники, що їх характеризують, рівні розвитку (високий, достатній̆, задовільний), а також методи та засоби діагностики, що надасть змогу визначити сучасний̆ стан та передбачити динаміку розвитку комунікативної компетентності. Проаналізовано розвиток комунікативної компетентності офіцерів-прикордонників в умовах сучасної магістерської освіти.
Manly Colors: Masculinity and Mobility among Globalizing Korean Men
Authors: Jong-Seok Lee Alex
Published: February 2020

South Korea and its mobile citizens provide a fruitful point of entry for observing how US-based racial hierarchies shift and circulate through and against transnationally and locally inflected ideologies of race, nation, gender, and sexuality. This article explores how the Korean state’s aspirations for global significance and regional dominance express themselves as staged presentations of ostensibly superior Asian masculinity at home (in Asia) and abroad (in the West). Against the backdrop of the South Korean state’s zealous globalizing efforts, cisheteronormative Korean men increasingly assert aspirational Korean masculinities within a transnational field of ranked races and nations. Korean males’ complex and contingent proximities to whiteness demonstrate how state efforts to transform the image of South Korea from a notoriously inhospitable “backward country” (hujin’guk) to a welcoming “advanced country” (sŏnjin’guk) play out in diverse everyday contexts. In making this claim, I follow recent scholarship on men in contemporary Asia that stresses the need for analyzing masculinity through the lens of sexuality and desire. Additionally, this article extends the analysis of practices that transgress the socially constructed boundaries of heteronormative masculinity (e.g., homosocial bonding) beyond the realm of sexuality-defined gay masculinities.
Your Life Is a Fraction of a Journey
Authors: Esparza Ofelia , Ahrens Rosanna Esparza
Published: February 2020

On March 1, 2019, the Transformative Arts Network at the University of California, Santa Barbara, held a two-day “Art, Activism, and Imagination” symposium. One memorable and infinitely generative part of the symposium came at the start of the second session, which was dedicated to the collaborative work between artists affiliated with the Alliance for California Traditional Arts and the Building Healthy Communities project in Boyle Heights in East Los Angeles. Altar makers Ofelia Esparza (a National Endowment for the Arts Heritage Fellow) and her daughter Rosanna Esparza Ahrens (graphic designer and cofounder of the artist collective Tonalli Studio—A Place of Creative Wellness) began the afternoon with an instructional session on “how to arrive” followed by a presentation about their work as altaristas.

As participants gathered on a verdant lawn next to a peaceful lagoon near the ocean, the altar makers burned sage and spoke about our obligations at a meeting convened on unceded Indigenous land. Rosanna outlined the four-part process that has guided the process of making altars. This consists of (1) arriving with full awareness of ourselves, our ancestors, and the powers of the natural world; (2) connecting fully with the natural and human world; (3) making agreements for collective conduct; and (4) affirming the possibilities produced by our collective practice. This process guided all the subsequent deliberations of the symposium and has informed much of the subsequent work that has emanated from it. One reason for its impact and influence stems from the extraordinary presentation about altar making that Ofelia and Rosanna presented, which enacted the ideals that the four parts of “learning to arrive” envision. With their permission, we reprint here a transcript of part of their inspiring and enlightening presentation.
Education Is Improvisation: Improvisation Is Art
Authors: Morgan Jerome
Published: February 2020

Art, Activism, and Imagination are pillars of our justice, freedom, and peace. Everyone has multiple means to express themselves artfully. In this day and time, if truly educated, everyone should be an activist on issues of equality. Imagination is the vehicle of knowing oneself, and creating art offers ownership.
Relief in Aeolian Environment. The Surface of Nida Settlement
Authors: Pilkauskas Mindaugas , Piličiauskas Gytis , Vengalis Rokas
Published: February 2020

During archaeological investigations in Nida settlement in 1974–1978, 2011–2013 and 2016 a lot of stratigraphic data from considerably wide area was gathered. Based on stratigraphy Neolithic paleosol of Nida settlement can be distinguished and it can be used as proxy for reconstruction of paleorelief. Paleosol was recorded in former depressions or on eastward slopes of former dunes. Large area in western part of the settlement was affected by aeolian processes where paleosol did not survive and in the eastern part former surface plunge deeply under groundwater level, these limited the territory considerably for paleorelief reconstruction. Analysis of the paleosol and stratigraphy displayed layering of artefacts in some parts of the settlement, which was interpreted as at least two periods of human activity. Also, in some parts of Nida very thick layer (> 1 m) with artefacts have been recorded which formed because of combination of anthropogenic activity and natural processes. An important insight is made about ancient topographic location of Nida settlement. Based on geological, botanical and geophysical data from Nida and other parts of Curonian spit we argue that earlier interpretation is not supported by recent data and we suggest that Nida settlement was in eastern part of the spit, on the shore of Curonian lagoon.
STUDI IN SILICO: PREDIKSI PENGARUH MUTASI TITIK GEN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 (VEGFR2) TERHADAP STRUKTUR SEKUNDER PROTEIN
Authors: Karina Karina , Rosadi Imam , Rosliana Iis , Wahyuningsih Komang A.
Published: February 2020

Angiogenesis merupakan proses penting untuk pertumbuhan dan regenerasi sel. Salah satu protein yang berperan dalam angiogenesis adalah vascular endothelial growth factor (VEGF).  VEGF akan berinteraksi dengan reseptornya seperti vascular endothelial growth factor receptor-2 (VEGFR2) untuk meregulasi proses angiogenesis. Mutasi pada gen VEGFR2 pada manusia dilaporkan dapat menyebabkan penyakit strawberry mark (hemangioma). Oleh karena itu, perlu dilakukan studi dan penelusuran terkait mutasi yang berperan dalam terbentuknya hemangioma. Beberapa tahapan yang dilakukan untuk menganalisis pengaruh mutasi tersebut diantaranya dengan melakukan penelusuran informasi dasar dan komposisi gen VEGFR2, analisis ortolog dan paralog gen VEGFR2, dan analisis struktur sekunder protein VEGFR2 manusia. Hasilnya menunjukkan bahwa mutasi VEGFR2 pada basa ke-3741 yaitu sitosin (C) menjadi timin (T) dilaporkan ditemukan pada jaringan tumor hemangioma. Perubahan basa ke-3741 sitosin menjadi timin mengakibatkan perubahan asam amino prolin menjadi serin yang dapat berdampak pada regulasi ekspresi VEGF. Ortolog dan paralog dari gen VEGFR2 manusia adalah gen VEGFR2 mencit dan gen fibroblast growth factor receptor 1 (FGFR1) manusia. Hasil analisis pengaruh mutasi terhadap bentuk dan struktur protein menunjukkan tidak ada perubahan yang signifikan, namun posisi mutasi di bagian ekstraseluler sel diduga mempengaruhi regulasi ekspresi VEGF melalui ikatan ligan-reseptor.
ANTAGONISTIC TEST OF RIAU LOCAL FUNGAL ISOLATES AGAINST SOME PATHOGENIC IN CULTIVATED PLANTS
Authors: Safitri Nia , Martina Atria , Roza Rodesia Mustika
Published: February 2020

Tanaman budi daya merupakan tanaman yang sering diserang oleh cendawan pathogen, sehingga mengakibatkan penurunan populasi dan produksi tanaman. Pengendalian hayati dengan cendawan antagonis merupakan salah satu metode yang paling efektif dan lebih ramah lingkungan dalam menekan pertumbuhan patogen tanaman. Penelitian ini bertujuan untuk menguji aktivitas antagonis cendawan isolat lokal Riau terhadap beberapa cendawan patogen pada tanaman budi daya. Uji antagonis dilakukan secara in vitro dengan metode dual culture menggunakan lima belas cendawan isolat lokal Riau terhadap Fusarium oxysporum f.sp. lycopersici, Ganoderma philippii, G. boninense, Rigidoporus microporus dan Colletotrichum sansevieria. Hasil penelitian menunjukkan bahwa Trichoderma sp. PNE 4 memiliki aktivitas antagonis tertinggi dan isolat FER C1 serta isolat LLB07 hanya memiliki aktivitas antagonis yang tinggi dalam menekan pertumbuhan cendawan patogen. Trichoderma sp. PNE 4 mampu menghambat pertumbuhan miselium F. oxysporum sebesar 85,30%, G. Philippii (100%), G. boninense (100%), dan C. sansevieria (100%). Isolat FER C1 hanya menghambat R. Microporus (50,39%) dan isolat LLB07 menghambat G. philippii (52,20%). Trichoderma sp. PNE 4 merupakan cendawan uji yang terpilih sebagai cendawan antagonis, karena memiliki kemampuan daya hambat  >70%.Abstract Cultivated plants are often attacked by pathogenic fungi resulting in a decline of population and crop production. Biocontrol with antagonistic fungi is one of the most effective and environmentally friendly methods in suppressing the growth of plant pathogens. This study aims to examine the antagonistic activity of local isolates fungi Riau against some pathogenic fungi on cultivated plants. The antagonistic test was performed in vitro by dual culture method using fifteen local isolates fungal Riau against Fusarium oxysporum f.sp. lycopersici, Ganoderma philippii, G. boninense, Rigidoporus microporus and Colletotrichum sansevieria. The results showed that Trichoderma sp. PNE 4 isolate exhibited highest activites and  FER C1 and LLB07 isolates exhibited high activities suppressed the growth of the fungal pathogen. Trichoderma sp. PNE 4 isolate inhibited mycelial growth F. oxysporum (85.30%), G. philippii (100%), G. boninense (100%) and C. sansevieria (100%). FER C1 isolate only inhibited R. microporus (50.39%), and LLB07 isolate inhibited G. philippii (52.20%). Trichoderma sp. PNE 4 isolate is test isolates as fungal antagonistic.
Idiopathic Left Ventricular Tachycardia Originating in the Left Posterior Fascicle
Authors: Chen Hongwu , Chan Kit , Po Sunny S , Chen Minglong
Published: February 2020

Ventricular tachycardias originating from the Purkinje system are the most common type of idiopathic left ventricular tachycardia. The majority if not all of the reentrant circuit involved in this type of tachycardia is formed by the Purkinje fibres of the left bundle branch, particularly the left posterior fascicle. In general, slowly conducting Purkinje fibres (P1) form the antegrade limb, and normally conducting Purkinje fibres (P2) form the retrograde limb of the reentrant circuit of the ventricular tachycardia originating from the left posterior fascicle. Elimination of the critical Purkinje elements in the reentrant circuit is the route to successful ablation. While the reentrant circuit identified by activation mapping provides the roadmap to ablation targets, comparing the difference in the His-ventricular interval during sinus rhythm and tachycardia also helps to identify the critical site in the reentrant circuit.
EVALUATION OF EXTRACTS FROM DRY FRUITS BLACK BLUEBERRY (VACCINIUM MYRTILLUS L.) THROUGH ONE-DIMENSIONAL AND MULTIDIMENSIONAL REGRESSION ANALYSIS FOR PHENOLCARBOXYLIC ACIDS
Authors: Stefanova Radostina
Published: February 2020

The purpose of the study is to develop a technology for the production of dried blackberry extracts. Basic extraction parameters are established. The influence of the technological parameters of the extraction process on the content of phenolcarboxylic acids in blackberry extracts is analyzed.
The extracts obtained were determined with the amount of phenolcarboxylic acids for use in enriching fruit juices with biologically active substances.
The effect of the type of extractant, the duration and temperature of the extraction and the hydromodule on the color parameters were investigated.
The results of the planned experiment were statistically processed with the Statistica program.
The residuals were estimated and analyzed by normal probability of the residual schedule, the scatterplot of the residuals from the predicted values, and the frequency histogram of the residuals. All results are presented analytically and graphically.