bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Adversity Qoutient Terhadap Prestasi Akademik Santri Di Institut Agama Islam Tribakti Lirboyo Kediri
Authors: Amin Muhammad Mahrus , Miftahudin
Published: December 2022

This study aimed to determine the effect of the Adversity Quotient on Academic Achievement of Students Domiciled in Pondok Pesantren Haji Ya'qub. The method used in this research is quantitative using a purposive sampling technique; the sample used is 69 respondents. The results show the Adversity Quotient's significant influence on students' academic achievement in Pondok Pesantren Haji Ya'qub.
Melindungi Akidah Anak dari Bahaya Dunia Modern Melalui Pendidikan Keluarga
Authors: Sulistyanto Irwan , Styawati Yuslia
Published: December 2022

The Muslim personality is formed from an early age, parents as a Muslim must have a quality belief in monotheism. But it would be nice if parents also understand monotheism materials, so that parents can equip their children with knowledge that is supported by the example of monotheism so that the personality of a true Muslim is formed. The family is the first environment for the formation of the unity of the child. In writing this scientific paper, the author uses the type of research "library research" which is a study carried out to solve a problem using library materials. This study found that parents are the main element for the establishment of monotheism in the family, so that everyone is required to have good monotheism, so that they can equip their children with monotheism and materials that support it, besides that children can see their parents as role models who provide knowledge at the same time. experience, and direction. In addition, Nashih Ulwan explained that in forming a child's creed requires supervision, so that the child's condition is always monitored. Universally, Islamic principles teach parents to always supervise and control their children to be safe in this world and the hereafter.
Program Kelas Literasi sebagai Upaya Meningkatkan Minat Baca Peserta Didik
Authors: Saputri Rafida , Makhromi
Published: December 2022

This study examines how the implementation of literacy classes in improving students' reading skills at SDITA Kediri. Literacy in schools has an important role in fostering reading interest in students as a whole to make the school a learning organization and to make the school environment literate by presenting various reading books and accommodating various strategies so that students' reading interest increases. This research uses qualitative research methods with a descriptive approach. Data collection methods obtained through interviews, observation and documentation. The results showed that if the literacy class program in schools is implemented properly, it will have an important role in increasing students' reading interest, especially the role as a media for students to habituate reading.
Konstruksi Kepemimpinan Transformatif di Lembaga Pendidikan Islam
Authors: Mahfudh Mahfudh
Published: December 2022

This article aims to describe the concept of transformative ideal leadership in Islamic education institutions. The approach used in this article is descriptive qualitative with the category of literature review, where this approach has the characteristics of collecting information and data using various types of available materials such as documents, books, magazines, and historical stories. This study found that the ideal of perspective leadership in Islam is that which has similarities with prophetic leadership. The ideal Transformational Leadership in Islamic educational institutions, must have 4 leadership traits in the Prophets and Apostles (prophetic). The four dimensions include Shiddiq (honest and true), Amanah (responsible, trustworthy), Tabligh (delivering messages, vision-mission), Fathanah (intelligent).
Konstruksi Nilai-Nilai dalam Peristiwa Fathu Makkah
Authors: Rouf Hasbullah Abdur
Published: December 2022

Fathu Makkah is the conquest carried out by the Prophet Muhammad Saw in the 8th year H, where history records a conquest of the city without shedding any blood. The purpose of this research is to describe the values that are built in the events of Fath Al-Makkah. then this research was conducted using a qualitative approach that describes the results of research in accordance with its objectives and with analysis or often called the descriptive analysis method. This research found that Fathu Makkah was not only an event of the conquest of the city. But from this event, this research found several meanings that could be noble values that can be realized in everyday life. There are about 4 values contained in the story including: The value of openness, peace, forgiveness, and tawadhu. All of them make Fathu Makkah an important event in the history of Muslims and all mankind in general, that even in war conditions, we must prioritize human values as fellow creatures of God.
Strategi Pembelajaran pada Anak Berkebutuhan Khusus dalam Pendidikan Inklusi
Authors: Ainu Ningrum Nila
Published: December 2022

Children with special needs have their own perspective in learning a subject. Therefore, this article aims to analyze learning strategies for special needs children, which require a separate strategy according to their individual needs. This research uses qualitative research with a library research approach. Library study is a method that collects information or data relevant to the research topic through documents. The data in this article were obtained through literature studies in the form of books and journals. This research found that: 1) For schools to be able to maintain and improve the implementation of inclusive schools that are already running for the realization of equitable education, 2) for parents who have students with special needs to pay more attention to the development of children both academically and non-academically, and 3) for the government to pay more attention to inclusive education programs. Because in essence education does not belong to those who can afford it, but education is the human right of every human being in the world.
Rancang Bangun Media Pembelajaran Bahasa Jawa di Sekolah Dasar Berbasis Andorid
Authors: Astrada Dimas Danar , Hapsari Estuning Dewi
Published: December 2022

Perkembangan teknologi dapat membantu peningkatan kualitas pendidikan pada kegiatan pembelajaran. Pembuatan media pembelajaran berbasis mobile Android adalah bentuk inovasi peningkatan yang mampu dilakukan. Oleh karena itu di rancang bangun media pembelajaran interaktif pengenalan bahasa Jawa pada sekolah dasar berbasis Android. Penelitian ini bertujuan agar mengetahui cara merancang, membuat serta mengevaluasi aplikasi media pembelajaran interaktif bahasa Jawa pada sekolah dasar berbasis Android. Aplikasi media pembelajaran ini berisi beberapa fitur. Fitur yang ada seperti materi dan soal latihan untuk semester 1 dan 2 di kelas 2, informasi biodata pembuat, sumber dari materi dan soal latihan. Pada materi dan soal latihan yang disajikan diambil dari buku kurikulum 2013. Buku yang digunakan di SDN Krokeh adalah LKS. Metode yang digunakan yaitu dengan menggunakan metode Waterfall dan menggunakan perancangan HIPO (Hierarchy Input Process Output). Penelitian ini menghasilkan bahwa media pembelajaran interaktif pengenalan bahasa Jawa berbasis Android, dibuat dengan aplikasi Adobe Animated CC, dan CorelDraw. Implementasi media pembelajaran ini berupa materi bahasa Jawa, soal latihan, sumber materi, dan informasi. Hasil evaluasi menggunakan kesioner dengan responden sebanyak 10 siswa kelas 2. Berdasarkan hasil kuesioner dapat disimpulkan bahwa aplikasi media pembelajaran interaktif pengenalan bahasa Jawa pada sekolah dasar mendapatkan respon yang baik.
Kontribusi Displin Kerja terhadap Kinerja dengan Fasilitas Sebagai Moderating di Institut Teknologi dan Bisnis Nasional
Authors: Syahrizal Syahrizal , Nasution Zulkarnain
Published: December 2022

Penelitian ini bertujuan untuk mengetahui kontribusi disiplin kerja dan mengetahui interaksi antara disiplin kerja dan fasilitas kerja terhadap kinerja karyawan Institut Teknologi dan Bisnis Nasional Banyuasin. Populasi dalam penelitian ini seluruh karyawan Institut Teknologi dan Bisnis Nasional Bayuasin sebanyak 30 karyawan dengan menggunakan teknik jenuh. Alat analisis yang digunakan adalah Moderated Regression Analysis. Hasil penelitian menunjukkan 1) Disiplin kerja mempunyai kontribusi terhadap kinerja karyawan Bank sampah Banyuwangi, 2) Ada interaksi antara Disiplin kerja dan fasilitas kerja terhadap kinerja karyawan Institut Teknologi dan Bisnis Nasional Banyuasin.
RESEARCH OF MIGRATION PROCESSES: HISTORIOGRAPHICAL AND METHODOLOGICAL ASPECTS
Authors: ARTYMYSHYN Yuliia
Published: December 2022

The article outlines the main stages of the study of migration processes in English historiography from the end of the XIX century (in the works of Ernst Georg Ravenstein and Georg Simmel) till the beginning of the XXI century, and special attention is paid to the issue of population movement in the humanities. Classifications and typologies of the migration process by Henry Pratt Fairchild, William Petersen, Wilbur Zelinsky, Charles Tilly, and Robin Cohen are considered. How changes in scientific paradigms and the geopolitical situation have influenced trends in population movement research is observed. It’s highlighted that since the 1960s, with the introduction of several new methods in the humanities, scientists have actively used the comparative method in studying migratory movements. After the fall of the Iron Curtain, one group of researchers insisted on expanding migration studies to the global scope, while another suggested focusing on the participation of nation-states in this process. The author analyzed how the idea of transnationalism became widespread in the mid-1990s, eventually influencing the emergence of the so-called international approach to population movement research. It’s confirmed that other important modern trends are rethinking current approaches to the study of ethnicity and assimilation theories, increased attention to gender issues, and the paradigm of mobility. An interpretation of the concept of transfer proposed by the National Institute of Statistics and Economic Research is shown. Also, an explanation of the terms of forced migration according to the definitions of the International Organization for Migration – IOM, International Association for the Study of Forced Migration – IASFM is given. A brief problematic review of the works of Ukrainian sociologists, lawyers, and economists who have studied various aspects of the phenomenon of migration is considered. It is noted that there is an issue with the interpretation of the terms of resettlement, and deportation in most Ukrainian historical research.
A espiritualidade e religiosidade de pessoas em tratamento hemodialítico: revisão integrativa
Authors: Paz Denise Barcelos de Pádua , Lopes Soraia Geraldo Rozza , Barboza Elton Santo , Barbosa Ana Paula Denis , Santos Priscila Gonçalves Soares dos
Published: December 2022

Objetivo: A doença renal crônica terminal (DRCT) ocasiona um grande impacto na qualidade de vida do indivíduo portador. Neste contexto, a espiritualidade e religiosidade são vistos como recursos que possam ajudar estas pessoas a lidarem com a sua enfermidade. Portanto, este trabalho parte da seguinte questão norteadora: “Como a espiritualidade e a religiosidade influencia na vida das pessoas em tratamento hemodialítico?”. O objetivo foi identificar evidências sobre como a espiritualidade e religiosidade pode influenciar a vida do paciente renal crônico terminal em hemodiálise. Método: Constitui de uma revisão da literatura do tipo integrativa, realizada por pares, nas seguintes bases: PubMed, Web of Science, CINAHL, Science Direct, BVS, em fevereiro de 2022, foram adotados como critérios de inclusão artigos primários e excluídos artigos secundários, seguindo as recomendações do método. Resultado: Foram identificados 994 registros, e 987 estudos irrelevantes para a revisão, duplicatas, editoriais e resumos de congresso foram descartados, restando sete artigos. Após a leitura na integra cinco artigos foram selecionados para a revisão. Conclusão: Os benefícios da espiritualidade e religiosidade no enfrentamento das diversidades encontradas pelo renal crônico em hemodiálise durante o seu tratamento, mostraram se presentes neste estudo, no entanto ressaltou a necessidade de agregar novos conhecimentos sobre a temática no aperfeiçoamento da assistência do indivíduo.
Yeni Dinî Kimlik Oluşum, Şekillenme ve İfade Etme Aşamalarında Sosyal Medyanın Rolü: Japon Müslümanlar Örneği
Authors: KOCALAN Elif Büşra
Published: December 2022

Çağdaş dünyada sosyal medya, bireylerin dinî kimliklerinin oluşturulması, şekillendirilmesi, sürdürülmesinde ve ifade edilmesinde önemli bir rol oynamaktadır. Bu araştırmanın amacı, Müslüman olan Japonların yeni dinî kimliklerinin oluşturulmasında ve sürdürülmesinde sosyal medyanın ne kadar etkili olduğunu ve aynı şekilde Japon Müslümanların yeni dinî inançlarını beyan etmek ve açıklamak için sosyal medyayı ne ölçüde kullandıklarını incelemektir. Makale Japonya’da iki buçuk yıla yakın yürütülen saha çalışmasının verilerine dayanmaktadır. Nitel araştırma veri toplama yöntemleri olan yarı yapılandırılmış mülakat, katılımcı gözlem ve saha notlarına başvurulmuştur. Mülakatlar, kartopu ve amaçlı örneklem metotları ile ulaşılan ve yaşları 19 ile 81 arası değişen 32 kadın 30 erkek toplam 62 kişi ile yapılmıştır. Çeşitli cami, mescit ve derneklerin etkinliklerine katılmak suretiyle Japon Müslümanlar ile iletişime devam ederek gözlemler yapılmış ve saha notları tutulmuştur. Hedef, sosyal medya ve dinî kimlik konusunun Japon Müslümanların deneyimleri özelinde ne anlam ifade ettiğini anlamak olduğu için veriler fenomenolojik bir bakış açısıyla incelenmiştir. Araştırmada, sosyal medyanın Japonların Müslüman kimliği ile karşılaşma ve bu kimliğin oluşumu üzerine fazla bir rolü olmadığı görülmüştür. Bununla birlikte, azınlık olan ve Japonya’nın muhtelif bölgelerine dağılmış ve başka türlü bir araya gelmeleri kolaylıkla mümkün olmayacak Japon Müslümanların birbirleriyle ve göçmen Müslümanlar ile bağlantılar kurarak dinî kimliklerini şekillendirme, sürdürme ve meşrulaştırmasında sosyal medyanın son derece mühim bir rolü bulunmaktadır. Öte yandan, sosyal medya Japon Müslümanların yeni dinî kimliklerini kendi toplumlarına beyan etmek için sık başvurdukları bir araç değildir.
Serika'dan Metinlerarasılığa: Abdülkâhir el-Cürcânî Örneği
Authors: AĞIRKAN Müfide
Published: December 2022

Metinlerarasılık, modern dönemde özellikle altmışlı yıllarda Batı’da “intertextuality ”, Doğu’da ise “التَّنَاص” (et-tenâs) terimiyle ortaya çıkmış edebî bir terimdir. Terimin klasik Arap edebiyatının ilk dönemlerinden itibaren farklı isimlendirmelerle kendine yer bulduğu görülür. Bu çalışmanın amacı, klasik Arap edebî tenkit geleneğinde serika kapsamında ortaya konan görüşler çerçevesinde Abdülkâhir el-Cürcânî’nin (ö. 471/1078-79) bu kurama yaklaşımını incelemek ve bu kuram çerçevesinde metinlerarasılık terimine karşılık gelen görüşlerini ala almaktır. Bu minvalde çalışma, Abdülkâhir el-Cürcânî’nin edebî eleştiri kapsamında serikaya dair olumlu/olumsuz görüşleri ve bu kurama yaklaşım metotları içerisinde metinlerarasılık kuramını karşılayan görüşleri ile sınırlandırılmıştır. Çalışmada genel olarak Arap edebî tenkit eserlerinde serika kuramı, özel olarak Abdülkâhir el-Cürcânî’nin metinsel ilişkilere karşılık gelen serika ile ilgili görüşleri sunulmuştur. Serika kuramı başta klasik Arap tenkitçileri olmak üzere ilk dönemlerden itibaren bu kuramın seyrine kısaca değinilerek Cürcânî’de nasıl ele alındığı temellendirilmiştir. Aynı zamanda çalışmada tasvîr, örneklendirme ve betimleme yöntemleri ele alınmakla birlikte Cürcânî nezdinde yer bulan kuramı açıklayan örnek verilere de yer verilmiştir. Buradan hareketle de makalenin asıl gayesi olan metinlerarasılık teriminin aslında ilk olarak altmışlı yıllarda modern dönemde ortaya atılmadığı, aksine klasik dönemlerden beri farklı terimlerde zikredildiği ve bu terimi Cürcânî’de serika kuramı karşıladığı hakikatinin temellendirilmesidir. Dolayısıyla Cürcânî'nin metinlerarasılık ile ilgili görüşlerini bu bağlamda irdelemek, kuramın sanatsal değerini ortaya koyma bakımından önemlidir. Öyle ki serikayı, sanatsal üstünlüğü sağlayan bir nitelik olarak değerlendiren Cürcânî, bu kuramın metinlerarasılık ile örtüşen pek çok örneğini zikretmiştir. Cürcânî'nin nazm teorisi odaklı çalışmaları, metinlerarasılık kuramının bu paradigma çerçevesinde değerlendirilmesini gerekli kılmıştır. Bu minvalde o, metinlerarasılıkla alakalı birçok hususa nazm teorisi bağlamında değinmiştir. Metinlerarasılık olgusu, Abdülkâhir el-Cürcânî'nin Delâilü'l-i‘câz ve Esrârü'l-belâga isimli eserlerinde oldukça yaygın bir kullanım olan “سرقات شعرية” (serikât-ı şi‘riyye) kavramı ekseninde irdelemiştir. Cürcânî'nin bu meseleyi oldukça kapsamlı bir biçimde serika terimi altında karakterize ettiğini ortaya koymak çalışmanın temel sorunsalıdır.
Biotinylated polymeric micelles based on amphiphilic poly(HPMA) block copolymers
Authors:   , Wang Yan
Published: December 2022

Polymeric micelles have attracted growing attention for drug delivery purposes during the last three decades. Poly(ethylene glycol) (PEG) has been used as the gold standard for coating drug-loaded nanoparticles. Due to unwanted pharmacokinetic issues of PEG after the second dose, there is a high demand to explore other synthetic hydrophilic uncharged polymers. Poly(N-(2-hydroxypropyl) methacrylamide) (pHPMA) is a promising PEG alternative as the shell-forming polymer of polymeric micelles due to its high hydrophilicity, its proven biocompatibility in many applications as a component of drug delivery systems, and possibilities for functionalization. To render these micelles with targeting potential for cancer cells, biotin was decorated on their surface. This thesis describes the development of PEG-free and fully p(HPMA)-based polymeric micelles potentially suitable for cancer treatment. This thesis sheds light on the synthesis, characterization, in vitro stability and release, and in vivo applications of biotin-decorated fully p(HPMA)-based micelles for targeted drug delivery. The biotinylated micelles can not only act as solubilizers and actively targeted drug carriers but also as a platform to quantify drug release and retention. The obtained results show that the biotinylated polymeric micelles fully based on a poly(HPMAm) backbone are promising candidates for targeted therapy and encourage further pharmaceutical development.
First cytogenomic characterization of murine testis tumor cell line MLTC-1
Authors: Azawi Shaymaa , Kankel Stefanie , Liehr Thomas , Rincic Martina
Published: December 2022

The cell line MLTC-1 was established in 1982 as a transplantable Leydig cell tumor from a C57BL/6 mouse. The cell line has already been applied in >100 studies: still, the only information about its genetic content is given in the first description: MLTC-1 initially had a polyploid karyotype. Here, a molecular karyotyping and multicolor banding-based molecular cytogenetic study was done to provide the first chromosomal/ (molecular) cytogenetic characterization of MLTC-1. A hexaploid karyotype with 72 to 105 chromosomes was hereby characterized. Besides polyploidy, unbalanced two- and three-way translocations, dicentrics and one neocentric derivative were identified. Also, no Y-chromosome could be detected in this clearly male derived cell line. Overall, a completely unbalanced genome is present in MLTC-1 with ~20 regions being subject to copy number losses or gains. After translating these imbalances into the human genome in a standardized way, a 40% match of imbalances with human Leydig cell tumors was evident; however, about the same rate of concordance was detectable for human spermatocytic seminomas and non-seminomas as well as testicular germ cell tumor. Accordingly, MLTC-1 is better suited as an advanced testicular germ cell tumor model in general, rather than specifically for human Leydig cell tumors.
Research on the Rose Wines Production in Azerbaijan
Authors: Imanova K. , Haydarov E. , Lezgiev Yu. , Musayev T. , Aliyeva G.
Published: December 2022

The native Matrasa grapes variety grown in the Samukh (79 m), Ganja (408 m) and Goygol (630 m) districts located at different altitudes above sea level, was used. Storage of pulp was carried out at different times — 3, 6, 12, 24 hours. Before maceration, desulfurization of the pulp is carried out. As a result of the tasting conducted according to a 10-point system with the participation of 9 tasters, a sample of rose wine aged in a pulp for 6 hours became more noticeable due to its transparency and color. At the same time, in terms of taste, typicality, aroma and bouquet, this sample was more preferable and eventually received a score of 9.6 points. Although there was no sharp difference between the number of aromatic substances in wine materials obtained from the Matrasa grape variety grown in different regions, some differences were still noticeable. Thus, the total amount of aromatic substances was 90.9 mg/dm3 in the wine material from the Goygol district, 88.6 mg/dm3 in Ganja and 85.6 mg/dm3 in Samukh. It turned out that in the sample of Samukh wine the content of acetates of higher alcohols was 5.7 mg/dm3, in Goygol — 5.2 mg/dm3 and, finally, in Ganja — 4.6 mg/dm3. Looking at the number of esters in both tables, it becomes clear that in the samples of wine from fatty acid esters the most common ethylhexanoate (1040-1210 mg/dm3) and ethyl-4-ONE-butanoate (1015-1430 mg/dm3).
E-Portfolio for Online Assessment: Padlet Implementation
Authors: Puspita Nurul , A. Hasyim Umar Alfaruq
Published: December 2022

e-Portfolio is a collection of students’ works. In the other words, it aids including storage and greater access to a broader student for sharing of ideas and discussion. Furthermore, the use of Padlet is needed during online assessment. Padlet is digital wall that facilitates the student in sharing all types of files and doing discussion. In this case, the use of Padlet as a digital wall to compile student’s works in one storage. In addition, the aim of this research is to describing the process of online assessment in Padlet as known as e-Portfolio. This research is conducted in fourth semester students of English Education Study Program, UIN Raden Intan Lampung. This research would show the process of online assessment done by the students in methodology of TEFL course. The researcher has prepared the wall in Padlet. The students share their works and start doing peer assessment. Finally, it is extremely helpful activities that is done in online setting

Kata Kunci: Online Assessment, Padlet Imlementation, Portofolio Online
Faktor Yang Berhubungan Dengan Penggunaan TOGA (Tanaman Obat Keluarga) Dalam Meningkatkan Kesehatan Masyarakat Di Pagatan Kecamatan Kusan Hilir
Authors: Jannah Miftahul , Melviani Melviani , Sarkiah Sarkiah
Published: December 2022

Pendahuluan: Kesehatan termasuk hal yang sangat penting bagi manusia, salah satunya dengan melakukan pengobatan sendiri dirumah dengan bahan alami atau berbahan dari alam. Penggunaan TOGA disebabkan oleh tingkat kesadaran masyarakat  akan kesehatan yang cukup tinggi dan pengetahuan akan TOGA yang semakin banyak dari tiap individu di masyarakat. Tujuan : Tujuan dari penelitian ini adalah untuk mengetahui faktor yang berhubungan dengan penggunaan Tanaman Obat Keluarga (TOGA) di masyarakat Pagatan.   Metode : Metode yang digunakan pada penelitian ini adalah menggunakan metode Cross Sectional.  Pengambilan sampel menggunakan metode consective sampling dengan analisis data dari Nilai p-Value yang dihasilkan setelah dimasukkan ke SPPS dengan menggunakan metode Chi-Square. Hasil : Hasil penelitian yang didapatkan dapat diketahui dari 50 orang responden terdapat 36 orang yang menggunakan TOGA. Variabel yang berhubungan dengan penggunaan TOGA dalam meningkatkan kesehatan masyarakat adalah usia (p = 0.040) dan pendapatan (p = 0.028), serta yang tidak berhubungan adalah pendidikan (p = 0.725) dan informasi (p = 0.865).Kesimpulan : Hasil penelitian menunjukkan ada 2 faktor yang berhubungan dari faktor usia dan pendapatan sedangkan untuk faktor pendidikan dan informasi tidak memiliki hubungan.
Profil Penggunaan Antibiotika di Puskesmas Hantakan dan Profil DAGUSIBU Antibiotika di Desa Hantakan dan Desa Alat
Authors: Saputri Rina , Hakim Ali Rakhman
Published: December 2022

Latar Belakang : Penggunaan antibiotika di Indonesia terus meningkat, tetapi tidak diiringi dengan pengetahuan yang baik terkait penggunaan antibiotika tersebut sehingga beresiko tinggi menyebabkan resistensi antibiotika.

Tujuan : Mengetahui profil penggunaan Antibiotika di Puskesmas hantakan dan mengetahui profil DAGUSIBU antibiotika di Desa Hantakan dan Desa Alat.

Metode : Jenis penelitian yang dilakukan adalah penelitian deskriptif dengan metode survey selama 5 bulan terakhir dari Oktober 2020 hingga Februari 2021. Survey juga dilakukan langsung ke responden Desa hantakan RT. 01 – RT. 06 dan di Desa Alat RT. 01 – RT. 04.

Hasil : Penggunaan Antibiotika di Puskesmas Hantakan termasuk 10 besar obat yang sering diresepkan. Jenis antibiotik yang paling banyak diresepkan adalah Amoxicillin. Profil DAGUSIBU pada responden menunjukkan mayoritas responden mendapatkan antibiotika dari warung, menggunakan antibiotika untuk mengatasi berbagai penyakit, mengonsumsi antibiotika tidak sesuai dengan interval, menghentikan antibiotika jika dirasa kondisi sudah membaik, dan masih menyimpan antibiotika sebagai stok persediaan serta membuang antibiotika dengan cara yang tidak tepat.

Simpulan : Amoxicillin merupakan jenis antibiotika yang paling banyak diresepkan di Puskesmas Hantakan. Penggunaan Antibiotika tanpa resep dokter di Desa Hantakan dan Alat masih tinggi. Pengelolaan antibiotika yang tepat pada responden di Desa Hantakan dan Alat masih rendah.
Potential Content of Karamunting (Rhodomyrtus tomentosa) in Binding With HMG-CoA Reductase
Authors: Nastiti Kunti - , Hadi Samsul
Published: December 2022

Latar Belakang: Hiperlipidemia adalah tingkat abnormal tinggi lemak (lipid) dalam darah. Dua jenis lipid yang diamati dalam kasus ini adalah trigliserida dan kolesterol. Dan enzim enzim yang berperan dalam regulasi kolesterol adalah HMG-CoA reduktase.

Tujuan : Mencari kandungan senyawa karamunting yang memiliki stabilitas interaksi dengan HMG-CoA reduktase.

Metode : Untuk melihat  probabilitas aktivitas adalah webservice, untuk interaksi senyawa-protein dengan PLANTS, visualisasi dengan Discovery studio. 

Hasil : Probabilitas ativitas dengan nilai minimal 0,5 yaitu α-tocopherol-quinone, naringenin, kuersetin, α-tocopherol A , verimol K. Nilai skor docking minimal 80% terhadap ligand reference yaitu  α-tocopherol-quinone (100%), blumeatin (82%), rhodomyrtosone C (80%), tetrahydroxyflavanone (81%), α-tocopherol A  (86%).

Simpulan : Probabilitas aktivitas senyawa yang paling berpotensi adalah α-tocopherol A dan  stabiltas interaksi adalah α-tocopherol-quinone
Evaluasi Penanganan Nyeri Haid (Dysmenorrhea) Dengan Protection Motivation Theory
Authors: Haditya Tasya , Mardlatillah Mardlatillah , Ain Farah Nur , Syifa Nur , Fadhli Muhammad Akhzani
Published: December 2022

Latar belakang: Menstruasi yang dikenal dengan nama haid atau datang bulan merupakan perubahan  fisiologis  dalam  perempuan  yang  terjadi  secara   berkala   dan dipengaruhi oleh hormon reproduksi, yang  dimulai  dari  menarche  sampai menopouse. Kelainan  atau  gangguan yang ada hubungan dengan  menstruasi  diantaranya  premenstrual  tension (ketegangan sebelum haid), mastodinia (rasa nyeri pada payudara), mittelschmerz (rasa nyeri saat ovulasi),  dan  dysmenorrhea  (rasa  nyeri  saat  menstruasi).  Nyeri haid (dysmenorrhea) adalah salah satu  kelainan  yang  menyebabkan  perempuan muda pergi ke dokter untuk berkonsultasi dan berobat. Nyeri haid atau disebut Dysmenorrhea adalah nyeri yang  biasanya  timbul pada masa remaja, yaitu sekitar  2  sampai  3  tahun  setelah  menstruasi  pertama.  Nyeri haid merupakan keluhan  yang  sering  dialami  remaja pada  bagian perut bawah (Kusmiran, 2013). Nyeri haid membuat perempuan tidak bisa beraktivitas secara normal dan memerlukan resep obat. Keadaan tersebut menyebabkan menurunnya kualitas  hidup  perempuan,  sebagai   contoh  mahasiswi yang mengalami nyeri haid primer tidak dapat berkonsentasi dalam belajar  dan motivasi belajar menurun karena nyeri yang dirasakan.

Tujuan: Untuk melihat serta mengevaluasi perilaku pada penderita nyeri haid (dysmenorrhea) dalam melakukan perilaku protektif (protection motivation theory).

Metode: Penelitian yang bersifat evaluatif yang bertujuan untuk melihat kerasionalan penanganan nyeri haid (dysmenorrhea) pada mahasiswi Fakultas Kesehatan Universitas Sari Mulia Banjarmasin. Pendekatan yang digunakan pada desain penelitian ini adalah cross sectional study dimana data dikumpulkan pada satu waktu tertentu. Pengambilan data dilakukan di Fakultas Kesehatan Universitas Sari Mulia Banjarmasin pada bulan April-Mei 2021.

Hasil: Pada project kali ini telah dilakukan riset terhadap Evaluasi Penanganan Nyeri Haid (Dysmenorrhea) dengan Protection Motivation Theory. Kami menyebarkan 21 pertanyaan dan mendapatkan 80 responden dari berbagai jurusan dan semester yang ada di fakultas kesehatan, yaitu 51,2% mahasiswi farmasi, 28,7% mahasiswi keperawatan, 13,7% mahasiswi kebidanan dan 6,3% mahasiswi promosi kesehatan. Dari 80 responden tersebut pula terdiri atas 52,5% mahasiwi semester 4, 31,3% mahasiswi semester 2, 12,5% mahasiswi semeter 6 dan 3,7% mahasiswi semester 8. Rentang usia responden ialah berkisar antara 18-22 tahun.

Kesimpulan: Responden melakukan usaha perlindungan diri dari nyeri haid (dysmenorrhea) yang dirasakan dengan cara melakukan terapi, baik secara farmakologi dan non farmakologi. Responden berusaha untuk melakukan pengobatan yang rasional seperti penggunaan dosis yang tepat, frekuensi, dan cara pakai yang tepat.
Pengaruh Budaya Terhadap Penggunaan TOGA (Tanaman Obat Keluarga) Di Masyarakat Desa Terombongsari
Authors: Shofia Diah Vinalisa Hasna , Yuwindry Iwan , Rahman Faisal
Published: December 2022

Latar Belakang: Masyarakat Desa Terombongsari sangat banyak yang menggunakan TOGA (Tanaman Obat Keluarga) sebagai terapi secara mandiri. Masyarakat disana cenderung lebih memilih TOGA dibandingkan pengobatan secara sintetis selain minim efek samping, TOGA juga mudah didapatkan dipekarangan rumah masyarakat. Masyarakat memutuskan melakukan pengobatan mandiri dipengaruhi oleh beberapa faktor, salah satunya yaitu budaya. Budaya diartikan sebagai kebiasaan secara turun temurun yang terjadi di masyarakat Desa Terombongsari.

Tujuan: Penelitian ini bertujuan menganalisis pengaruh budaya terhadap penggunaan TOGA di masyarakat Desa Terombongsari.

Metode: Penelitian ini menggunakan jenis penelitian Observasional Analitik dengan desain penelitian cross sectional. Sampelnya yaitu masyarakat dewasa usia minimal 17 tahun yang berjumlah 92 KK yang rutin menggunakan TOGA. Pemilihan sampel dengan metode purposive sampling. Pengumpulan data dengan lembar kuesioner, data dianalisis menggunakan uji Kendall tau-b dengan tingkat kepercayaan 95%.

Hasil: Hasil menunjukan sebanyak 79,3% budaya penggunaan TOGA yang ada dimasyarakat Desa Terombongsari bernilai positif. Hasil dalam penggunaan TOGA masuk kategori baik sebanyak 90,2%. Hasil analisis bivariat diperoleh nilai p – value yaitu 0,0001 yang artinya Ha di terima.

Simpulan: Terdapat pengaruh budaya terhadap penggunaan TOGA di masyarakat Desa Terombongsari.
Pendekatan Health Belief Model (HBM) Untuk Menganalisis Kepatuhan Pasien Diabetes Mellitus Dalam Menggunakan Insulin Di Kota Banjarmasin
Authors: Sariyasih Sariyasih , Yuwindry Iwan , Syamsu Erlina
Published: December 2022

Latar Belakang: Health Belief Model (HBM) merupakan teori yang digunakan untuk memahami sikap serta prilaku kesehatan terhadap suatu penyakit, hbm terdiri faktor persepsi kerentanan, persepsi keparahan, persepsi manfaat, persepsi hambatan, dan pemicu untuk bergerak. Upaya pencegahan penyebaran virus covid-19 di Indonesia dilakukan dengan menetapkan peraturan untuk melakukan vaksinasi covid-19 terutama pada lansia yang rentan terinfeksi dengan cakupan vaksinasi sebesar 70% untuk mencapai Herd Immunity.

Tujuan: Mengetahui faktor persepsi kerentanan, persepsi keparahan, persepsi manfaat, dan persepsi hambatan dalam mempengaruhi persepsi lansia terhadap penerimaan vaksinasi covid-19 di Kabupaten Tanah Bumbu.

Metode: Penelitian ini merupakan cross sectionaldengan jenis penelitian yang digunakan adalah kuantitatif. Metode pengambilan sampel dengan teknik purposive sampling dan instrument yang digunakan pada penelitian adalah kuesioner dengan google form. Analisis data yang digunakan adalah Univariat, Bivariat dengan Chi Square, dan Multivariat dengan regresi logistic.

Hasil: Penelitian menunjukkan dari 120 responden lansia di Kabupaten Tanah Bumbu didapatkan sebanyak 65.8% lansia menyatakan akan melakukan vaksinasi covid-19. Faktor yang dominan dalam mempengaruhi vaksinasi adalah persepsi hambatan yaitu khawatir kemungkinan terjadi infeksi dalam waktu dekat yang tinggi. Faktor persepsi kerentanan, keparahan, manfaat dan hambatan memiliki pengaruh dengan penerimaan vaksinasi pada lansia di Tanah Bumbu. Faktor demografis (usia, jenis kelamin, pekerjaan, pendidikan, agama, pernah atau tidaknya didiagnosis penyakit kronis) tidak memiliki pengaruhyang signifikan dengan penerimaan vaksin covid-19 di Kabupaten Tanah Bumbu.

Simpulan: 65.8% lansia di Tanah Bumbu menyatakan akan melakukan vaksinasi covid-19. Persepsi hambatan, manfaat, kerentanan, keparahan, dan pemicu untuk bergerak memiliki pengaruh terhadap penerimaan vaksinasi covid-19.
Penurunan Kadar Logam Timbal (Pb) Pada Daging Ikan Kelabau (Osteochilus melanopleurus) Dengan Filtrat Asam Jawa (Tamarindus indica)
Authors: Rachman Felix Imanuel , Rahmadani Rahmadani , Rizal Muhammad
Published: December 2022

Latar belakang: Asam jawa memiliki asam sitrat yang memiliki kemampuan mereduksi cemaran logam berat. Asam sitrat dengan gugus trikarboksilatnya dapat mengikat dengan logam berat dan menghasilkan ion kompleks serta memiliki sifat yang stabil berupa khelat.

Tujuan: Melihat pengaruh asam jawa terhadap logam berat timbal serta hubungan antara variasi konsentrasi asam jawa dengan penurunan kadar logam berat timbal pada daging ikan.

Metode: Penelitian ini menggunakan metode pra-eksperimental dengan pendekatan only-posttest design dengan menggunakan instrumen spektrofotometri serapan atom (SSA).

Hasil: Berdasarkan penelitian yang telah dilakukan, didapatkan penurunan kadar logam hasil perlakuan dengan asam jawa 5% adalah 63,923%, asam jawa 10% adalah 41,431%, dan asam jawa 10% adalah 26,484% dengan hasil signifikansi sebesar 0,715.

Kesimpulan: Berdasarkan hasil penelitian, didapatkan bahwa tidak adanya hubungan antara variasi konsentrasi asam jawa dengan kadar timbal.
Construction of a prognostic assessment model for colon cancer patients based on immune-related genes and exploration of related immune characteristics
Authors: Wan Yanhua , He Yingcheng , Yang Qijun , Cheng Yunqi , Li Yuqiu , Zhang Xue , Zhang Wenyige , Dai Hua , Yu Yanqing , Li Taiyuan , Xiong Zhenfang , Wan Hongping
Published: December 2022

Objectives: To establish a novel risk score model that could predict the survival and immune response of patients with colon cancer.

Methods: We used The Cancer Genome Atlas (TCGA) database to get mRNA expression profile data, corresponding clinical information and somatic mutation data of patients with colon cancer. Limma R software package and univariate Cox regression were performed to screen out immune-related prognostic genes. GO (Gene ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) were used for gene function enrichment analysis. The risk scoring model was established by Lasso regression and multivariate Cox regression. CIBERSORT was conducted to estimate 22 types of tumor-infiltrating immune cells and immune cell functions in tumors. Correlation analysis was used to demonstrate the relationship between the risk score and immune escape potential.

Results: 679 immune-related genes were selected from 7846 differentially expressed genes (DEGs). GO and KEGG analysis found that immune-related DEGs were mainly enriched in immune response, complement activation, cytokine-cytokine receptor interaction and so on. Finally, we established a 3 immune-related genes risk scoring model, which was the accurate independent predictor of overall survival (OS) in colon cancer. Correlation analysis indicated that there were significant differences in T cell exclusion potential in low-risk and high-risk groups.

Conclusion: The immune-related gene risk scoring model could contribute to predicting the clinical outcome of patients with colon cancer.
Impact of diastolic pulmonary gradient and pulmonary artery pulse index on outcomes in heart transplant patients—Results from the Eurotransplant database
Authors: Wagner Tobias , Magnussen Christina , Bernhardt Alexander , Smits Jacqueline M. , Steinbach Katrin , Reichenspurner Hermann , Kirchhof Paulus , Grahn Hanno
Published: December 2022

Background

Predicting complications associated with pulmonary hypertension (PH) after cardiac transplantation is an important factor when considering cardiac transplantation. The transpulmonary gradient (TPG) is recommended to quantify PH in transplant candidates. Nonetheless, PH remains a common driver of mortality. The diastolic pressure gradient (DPG) and pulmonary vascular resistance (PVR) can differentiate post- from combined pre- and post-capillary PH and may improve estimation of PH-associated risks. We used a large European cohort of transplant candidates to assess whether the pulmonary pulsatility index (PAPi), improves prediction of graft failure and mortality compared to DPG and PVR.

Methods

Out of all patients undergoing heart transplantation between 2009 and 2019 in Eurotransplant member states (n = 10,465), we analyzed the impact of PH (mPAP > 25 mmHg) and right heart catheter hemodynamic data on graft failure and mortality within 1–5 years.

Results

In 1,407 heart transplant patients with PH (79% male, median age 54 years, IQR 39–69 years), the median PVR was 2.5 WU (IQR 1.6 WU) with a median mPAP (pulmonary arterial pressure) of 32 mmHg (IQR 9 mmHg). Patients with low (< 3 mmHg) DPG had a better 5 year survival than those with higher DPG (log rank p = 0.023). TPG, mPAP, PAPi, and PVR did not improve prediction of survival. Low PAPi (OR = 2.24, p < 0.001) and high PVR (OR = 2.12, p = 0.005) were associated with graft failure.

Conclusion

PAPI and PVR are associated with graft failure in patients with PH undergoing cardiac transplantation. DPG is associated with survival in this cohort.
Research progress on the role of ferroptosis in cardiovascular disease
Authors: Li Han , Lin Li , Xia Yun-Long , Xie Yunpeng , Yang Xiaolei
Published: December 2022

The cardiovascular disease pathogenesis is extremely complex and seriously threatens human health. Cardiomyocyte death plays a significant role in cardiovascular disease occurrence and development. In addition to the previously revealed modes of cell death (apoptosis, autophagy, and pyroptosis), ferroptosis is highly related to the development of cardiovascular diseases, including arrhythmia, atherosclerosis, and myocardial ischemia/reperfusion. Ferroptosis is a novel cell death pathway driven by lipid peroxidation and iron overload. Lipid, amino acid, and iron metabolism regulate the ferroptosis pathway. Small molecule compounds (iron chelators, antioxidants, and ferroptosis inhibitors) and genetic programming can alleviate or prevent cardiovascular disease by inhibiting the ferroptosis pathway. Ferroptosis plays a key role in various cardiovascular disease occurrence and development, and inhibiting ferroptosis in cardiomyocytes is expected to become a feasible treatment method. In this mini-review, we systematically summarize the molecular mechanisms of ferroptosis in different cardiovascular diseases, delineate the regulatory network between ferroptosis and cardiovascular diseases, and highlight its potential therapeutic targets.
Clinical observation of sacubitril valsartan sodium in the treatment of resistant hypertension: A randomized clinical trial
Authors: Lyu Tian-Jiao , Liu Ying , Zhang Hong , Li Ling-Yan , He Rui-Qing , Gao Jun-Qing , Liu Zong-Jun
Published: December 2022

Objective

To investigate the effectiveness and safety of sacubitril valsartan sodium in the treatment of resistant hypertension (RH).

Methods

This study is a single-center, prospective, randomized controlled study. According to the inclusion and exclusion criteria, patients with RH who met the criteria were screened, and all patients adjusted their drug treatment (valsartan 80 mg, amlodipine 5 mg, and hydrochlorothiazide 12.5 mg). After 4 weeks of drug elution, the random envelope method was used for random grouping. The treatment group took sacubitril valsartan sodium 200 mg, amlodipine 5 mg, hydrochlorothiazide 12.5 mg, and the control group took valsartan 80 mg, amlodipine 5 mg, and hydrochlorothiazide 12.5 mg for 8 weeks. The 24 h ambulatory blood pressure (BP) and the echocardiography index using the office sphygmomanometer were observed in the patients.

Results

A total of 100 patients with RH were included in the two groups, with 50 cases in each group. There were no significant differences in sex, age, or comorbid diseases between the two groups. During the 8-week follow-up, the office BP of the research group were significantly decreased (24.78/17.86 mmHg) compared with those of the control group. In the research group the 24 h average BP, daytime average BP, and nighttime average BP were 144.84/79.82, 147.10/82.06, and 138.67/76.31 mmHg at baseline, and reduced to 128.96/73.32, 131.50/74.94, and 122.11/69.27 mmHg at week 8, which were significantly decreased (P < 0.05 or P < 0.01), and the left ventricular ejection fraction was significantly increased (P < 0.05), compared with the control group.

Conclusion

Sacubitril valsartan sodium can effectively reduce BP and improve cardiac function in RH.
Predictive nomogram model for major adverse kidney events within 30 days in sepsis patients with type 2 diabetes mellitus
Authors: Xin Qi , Xie Tonghui , Chen Rui , Wang Hai , Zhang Xing , Wang Shufeng , Liu Chang , Zhang Jingyao
Published: December 2022

Background

In sepsis patients, Type 2 Diabetes Mellitus (T2DM) was associated with an increased risk of kidney injury. Furthermore, kidney damage is among the dangerous complications, with a high mortality rate in sepsis patients. However, the underlying predictive model on the prediction of major adverse kidney events within 30 days (MAKE30) in sepsis patients with T2DM has not been reported by any study.

Methods

A total of 406 sepsis patients with T2DM were retrospectively enrolled and divided into a non-MAKE30 group (261 cases) and a MAKE30 group (145 cases). In sepsis patients with T2DM, univariate and multivariate logistic regression analyses were conducted to identify independent predictors of MAKE30. Based on the findings of multivariate logistic regression analysis, the corresponding nomogram was constructed. The nomogram was evaluated using the calibration curve, Receiver Operating Characteristic (ROC) curve, and decision curve analysis. A composite of death, new Renal Replacement Therapy (RRT), or Persistent Renal Dysfunction (PRD) comprised MAKE30. Finally, subgroup analyses of the nomogram for 30-day mortality, new RRT, and PRD were performed.

Results

In sepsis patients with T2DM, Mean Arterial Pressure (MAP), Platelet (PLT), cystatin C, High-Density Lipoprotein (HDL), and apolipoprotein E (apoE) were independent predictors for MAKE30. According to the ROC curve, calibration curve, and decision curve analysis, the nomogram model based on those predictors had satisfactory discrimination (AUC = 0.916), good calibration, and clinical application. Additionally, in sepsis patients with T2DM, the nomogram model exhibited a high ability to predict the occurrence of 30-day mortality (AUC = 0.822), new RRT (AUC = 0.874), and PRD (AUC = 0.801).

Conclusion

The nomogram model, which is available within 24 hours after admission, had a robust and accurate assessment for the MAKE30 occurrence, and it provided information to better manage sepsis patients with T2DM.
Triglyceride to high-density lipoprotein cholesterol ratio is an independent predictor of liver fibrosis among pediatrics non-alcoholic fatty liver disease
Authors: Ting Yi-Wen , Jalaludin Muhammad Yazid , Zaini Azriyanti Anuar , Mohamed Rosmawati
Published: December 2022

Background

Insulin resistance (IR), one of the key components of the metabolic syndrome, is recognized as the pathophysiological hallmark of non-alcoholic fatty liver disease (NAFLD). This study aims to investigate the relationship between surrogate markers of IR and the severity of NAFLD among overweight or obese children.

Methodology

A total of 56 consecutive children aged 6 to 18 years old were recruited from the pediatric obesity and type 2 diabetes mellitus (T2DM) clinic in University Malaya Medical Centre (UMMC) from 2016 to 2019. Data on anthropometric measurements, clinical components of metabolic syndrome and fasting serum insulin were collected. Triglyceride to high-density lipoprotein cholesterol ratio (TG: HDL-C), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and Single Point Insulin Sensitivity Estimator (SPISE) were calculated. Transient elastography was performed with hepatic steatosis and liver fibrosis assessed by controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), respectively.

Results

A total of 44 children (78.6%) had liver steatosis and 35.7% had presence of significant liver fibrosis (stage F≥2). Majority (89.3%) are obese and 24 children (42.9%) were diagnosed with metabolic syndrome. Higher number of children with T2DM and significant liver fibrosis were associated with higher tertiles of TG: HDL-C ratio (p<0.05). Top tertile of TG: HDL-C ratio was an independent predictor of liver fibrosis (OR=8.14, 95%CI: 1.24–53.36, p=0.029). ROC analysis showed that the area under the curve (AUC) of HOMA-IR (0.77) and TG: HDL-C ratio (0.71) were greater than that of metabolic syndrome (0.70), T2DM (0.62) and SPISE (0.22). The optimal cut-off values of HOMA-IR and TG: HDL-C ratio for detecting liver fibrosis among children with NAFLD are 5.20 and 1.58, respectively.

Conclusion

Children with NAFLD and higher TG: HDL-C ratio are more likely to have liver fibrosis. TG: HDL-C ratio is a promising tool to risk stratify those with NAFLD who are at risk of developing advanced liver disease.
Classification of diabetic retinopathy: Past, present and future
Authors: Yang Zhengwei , Tan Tien-En , Shao Yan , Wong Tien Yin , Li Xiaorong
Published: December 2022

Diabetic retinopathy (DR) is a leading cause of visual impairment and blindness worldwide. Since DR was first recognized as an important complication of diabetes, there have been many attempts to accurately classify the severity and stages of disease. These historical classification systems evolved as understanding of disease pathophysiology improved, methods of imaging and assessing DR changed, and effective treatments were developed. Current DR classification systems are effective, and have been the basis of major research trials and clinical management guidelines for decades. However, with further new developments such as recognition of diabetic retinal neurodegeneration, new imaging platforms such as optical coherence tomography and ultra wide-field retinal imaging, artificial intelligence and new treatments, our current classification systems have significant limitations that need to be addressed. In this paper, we provide a historical review of different classification systems for DR, and discuss the limitations of our current classification systems in the context of new developments. We also review the implications of new developments in the field, to see how they might feature in a future, updated classification.