bluuebunny/crossref_metadata_2025 huggingface dataset:
Grand Ethiopian Renaissance Dam vis-à-vis Hydropolitical Justice: Why Egypt and Ethiopia Engage in Hydropolitical Tension over the Dam?
Authors:   Gondar University, Endalew Getasew
Published: December 2023

The study was aimed to examine the Grand Ethiopian Renaissance Dam (GERD) from the viewpoint of hydropolitical justice and reveal the reason of Ethio-Egyptian hydropolitical tension over the dam. Conceptually, hydropolitical justice can be defined as procedurally inclusive, environmentally valid, politically sound, and economically reasonable plus distributionally benefit sharing utilization of transboundary water resources in the way of maximizing benefits and minimizing harms of all riparians. Through relying on this concept, the study has employed qualitative research method and utilized secondary sources of data. Accordingly, the analysis of this paper proved that the GERD is a project of water use management and development which fulfill imperative requirements for the birth and growth of hydropolitical justice over the utilization of the Blue Nile. Hence, GERD is a development project of water utilization which could enable both Egypt and Ethiopia to equitably share benefits of the Blue Nile without the worth of another. The analysis of this study assures, with evidence, that the dam has a potential to equitably maximize benefits and minimize harms of both Ethiopia and other lower riparians of the river. Thus, the hydropolitical tension of Egypt and Ethiopia is emanated not from the dam’s feature of strengthening a reasonable, equitable and non- significant harm principle of international water law. Rather from an equitably non-beneficial, legally baseless, scientifically unsupported and greedily motivated political insistency of Egypt so as not to recognize the necessity of GERD from the perspective of hydropolitical justice.
Prevalencia de la Retinopatía de la Prematuridad (ROP) en el Hospital Regional Docente Las Mercedes de Chiclayo durante los años 2007 - 2009
Authors: Gutiérrez Carmen , Vergara E. , Rojas P. , Labrín C.
Published: December 2023

El presente trabajo tiene el objetivo de describir la prevalencia de la Retinopatía de la Prematuridad (ROP) así como de las condiciones asociadas a la misma en recién nacidos atendidos en el Servicio de Neonatología del Hospital Regional Docente Las Mercedes Chiclayo 2,007-2,009.Se utilizó un diseño observacional retrospectivo, transversal, analítico.

Resultados: En el período en estudio se tamizó 353 recién nacidos, detectando algún grado de ROP en el 22%. La distribución por severidad fue 48.7% (ROP I), 35.5% (ROP II), 13.2 (ROP III), 1.3% (ROP IV) y 1.3% (ROP V). Severa ROP se reportó 32%. Requirieron tratamiento quirúrgico el 38% de casos. Respecto a los factores de riesgos: El 95% recibió oxígeno suplementario por casco, bigotera nasal, CPAP y/o ventilación mecánica. El Síndrome de Dificultad Respiratoria fue diagnosticado en el 93% de los casos. El peso al nacer menor de 1500 gramos fue característica de 64.4% de los afectados, y en el 54% la edad gestacional menor de 32 semanas. Predominó el sexo femenino (53%) en los casos. Fue diagnosticada sepsis en el 43.4%.

Conclusiones:  La Retinopatía de la Prematuridad (ROP) incluidas las formas graves, guardan relación inversamente proporcional a la edad gestacional menor de 32 semanas y peso menor de 1,500 gr. La asociación entre ROP, administración de oxígeno suplementario, síndrome de Dificultad Respiratoria y sepsis podría relacionarse con la atención perinatal con tecnología incompleta y desfasada, situación que deviene en el incremento de la morbilidad de los supervivientes neonatales prematuros.
Den metriske tilpasning
Authors: Brink Lars
Published: December 2023

Poetic meter is the set of prerequisites for how stressed and unstressed syllables should be arranged as a rule. The poet’s metrical adaptation aims to make the shades of stress in the language fit. This appears to be simple, since in all European traditions every traditionally defined heavy stress can be placed in unstressed position, while every secondary or light stress can be placed in accentuated positions (not to mention unaccentuated; thus “anything goes”). Nevertheless, we all know it is possible to commit metrical errors in poetic composition. There must then be an adaptation rule that cannot be broken. This rule is: Inversion is not allowed. A common phrase in daily speech with a well-defined stress pattern cannot have the opposite pattern in poetic meter. In Cole Porter’s famous lines I love Paris in the Springtime (the meter begins with two trochees) I love Paris in the fall ‘Paris’ could not be ‘Madrid’, since Madrid would require the opposite accentuation pattern than what occurs in daily speech.
Navnet i centrum
Authors: Sandst Line
Published: December 2023

In this article, I discuss how linguistic ambiguity arises and differs in spoken and written language situations in linguistic landscapes (LL). I investigate overall language comprehension, word formation and homonymy in order to understand why uncertainties occur and how language users can determine what is meant in a given context. In doing so, I suggest the necessity to distinguish between the spoken and written contexts of proper names in order to interpret a given name. I investigate the different modalities available and used in spoken and written name forms, respectively, and I clarify the importance of the discourse for placement of proper names as an important factor for distinguishing between proper names and other grammatical categories in LL.
ÇAĞDAŞ CAMİ MİMARİSİNDE DOĞAL AYDINLATMANIN KUTSAL IŞIK OLARAK KULLANILMASI
Authors: KULAK TORUN Firdevs
Published: December 2023

Aydınlatma mekân tasarımında önemli bir unsurdur. Aydınlatma düşünülerek kurgulanan mekanlarda kullanıcılara birçok mesaj verilebilmektedir. Dini yapılar kapsamında da ışığın iç mekânda tasarım unsuru olarak kullanılması önemli bir husustur. Özellikle doğal ışığın iç mekânda kutsal ışık rolünü üstlenmesi ile dini yapıların iç mekân algısı kullanıcılar üzerinde güçlendirilebilmektedir. Günümüzde çağdaş cami tasarımlarında özellikle doğal ışık, iç mekânda bir tasarım parametresi olarak görülmekte ve kutsal ışık olarak kullanılmaktadır. Ancak doğal ışığı kutsal ışık olarak kullanmak için dikkat edilmesi gereken kriterler de bulunmaktadır. Araştırmalar kapsamında kutsal ışık olarak değerlendirilebilecek doğal ışığın geldiği yüzey, yüzeyden gelen ışığın iç mekâna alınması esnasında kullanılan yöntem, ışığın iç mekânda oluşturduğu ışık-gölge durumu ve iç mekânda vurguladığı yüzeyler, kullanılan doğal ışığın türü ve özellikleri önemlidir. Bu sebeple doğal ışığın kutsal ışık olarak kullanılması için gerekli kriterler tespit edilmiştir. Ardından çağdaş cami Mimarisi kapsamında inşa edilmiş ve yapılar hakkında verilerin elde edilebileceği daha önce haklarında birçok çalışmanın bulunduğu örnekler belirlenerek örneklem oluşturulmuştur. Örneklem; Sancaklar Cami, Şakirin Cami, Marmara İlahiyat Cami, Etimesgut Cami ve TBMM Cami’leri olarak belirlenmiştir. Yapılar hakkında elde edilen veriler aktarılmıştır. Değerlendirme bölümünde ise yapılarda doğal ışığın kutsal ışık olarak kullanımında dikkat edilmesi gereken kriterlerin kıyaslanarak incelenmesi gerçekleştirilmiştir. Gerçekleştirilen değerlendirmelerden elde edilen veriler ise çalışmanın sonuç bölümünde açıklanmıştır.
Uma História Global e Brasileira da Aids, 1986-2021
Authors: Cueto Marcos , Lopes Gabriel
Published: December 2023

Em Uma História Global e Brasileira da Aids, 1986-2021, Marcos Cueto e Gabriel Lopes oferecem aos seus leitores uma espécie de aula magistral sobre como escrever a história da saúde coletiva na era global. Eles capturam a natureza interativa do sistema global contemporâneo, que certamente é caracterizado por muitas formas de desigualdade combinadas em configurações frequentemente neocoloniais. Eles também nos mostram que existe espaço para trocas bidirecionais e, mesmo no contexto da hegemonia neocolonial, é possível validar perspectivas alternativas de forma importante. Eles demonstram claramente que o tempo da análise histórica atrelada somente a unidades delimitadas, sejam comunidades locais sejam Estados-nação específicos, passou. A história da saúde e da medicina, na era da saúde global, só pode ser adequadamente compreendida com a devida atenção à complexidade das interações e interseções globais. Se os desenvolvimentos históricos locais e nacionais são profundamente impactados por processos e estruturas transnacionais, a saúde global também é influenciada e moldada por desenvolvimentos que ocorrem nacional e localmente; poucos estudos de caso estendidos ilustram isso tão claramente quanto esta história da resposta à aids no Brasil e das contribuições do Brasil para a resposta à aids no mundo.
Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination
Authors: Fukuhara Hideo , Yumoto Kohei , Sako Miyuki , Kajikawa Mizuho , Ose Toyoyuki , Kawamura Mihiro , Yoda Mei , Chen Surui , Ito Yuri , Takeda Shin , Mwaba Mwila , Wang Jiaqi , Hashiguchi Takao , Kamishikiryo Jun , Maita Nobuo , Kitatsuji Chihiro , Takeda Makoto , Kuroki Kimiko , Maenaka Katsumi
Published: December 2023

Canine distemper virus (CDV) belongs to morbillivirus, including measles virus (MeV) and rinderpest virus, which causes serious immunological and neurological disorders in carnivores, including dogs and rhesus monkeys, as recently reported, but their vaccines are highly effective. The attachment glycoprotein hemagglutinin (CDV-H) at the CDV surface utilizes signaling lymphocyte activation molecule (SLAM) and Nectin-4 (also called poliovirus-receptor-like-4; PVRL4) as entry receptors. Although fusion models have been proposed, the molecular mechanism of morbillivirus fusion entry is poorly understood. Here, we determined the crystal structure of the globular head domain of CDV-H vaccine strain at 3.2 Å resolution, revealing that CDV-H exhibits a highly tilted homodimeric form with a six-bladed β-propeller fold. While the predicted Nectin-4-binding site is well conserved with that of MeV-H, that of SLAM is similar but partially different, which is expected to contribute to host specificity. Five N-linked sugars covered a broad area of the CDV-H surface to expose receptor-binding sites only, supporting the effective production of neutralizing antibodies. These features are common to MeV-H, although the glycosylation sites are completely different. Furthermore, real-time observation using high-speed atomic force microscopy revealed highly mobile features of the CDV-H dimeric head via the connector region. These results suggest that sugar-shielded tilted homodimeric structure and dynamic conformational changes are common characteristics of morbilliviruses and ensure effective fusion entry and vaccination.
Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination
Authors: Fukuhara Hideo , Yumoto Kohei , Sako Miyuki , Kajikawa Mizuho , Ose Toyoyuki , Kawamura Mihiro , Yoda Mei , Chen Surui , Ito Yuri , Takeda Shin , Mwaba Mwila Hilton , Wang Jiaqi , Hashiguchi Takao , Kamishikiryo Jun , Maita Nobuo , Kitatsuji Chihiro , Takeda Makoto , Kuroki Kimiko , Maenaka Katsumi
Published: December 2023

Canine distemper virus (CDV) belongs to morbillivirus, including measles virus (MeV) and rinderpest virus, which causes serious immunological and neurological disorders in carnivores, including dogs and rhesus monkeys, as recently reported, but their vaccines are highly effective. The attachment glycoprotein hemagglutinin (CDV-H) at the CDV surface utilizes signaling lymphocyte activation molecule (SLAM) and Nectin-4 (also called poliovirus-receptor-like-4; PVRL4) as entry receptors. Although fusion models have been proposed, the molecular mechanism of morbillivirus fusion entry is poorly understood. Here, we determined the crystal structure of the globular head domain of CDV-H vaccine strain at 3.2 Å resolution, revealing that CDV-H exhibits a highly tilted homodimeric form with a six-bladed β-propeller fold. While the predicted Nectin-4 binding site is well-conserved with that of MeV-H, that of SLAM is similar but partially different, which is expected to contribute to host specificity. Five N-linked sugars covered a broad area of the CDV-H surface to expose receptor binding sites only, supporting the effective production of neutralizing antibodies. These features are common to MeV-H, although the glycosylation sites are completely different. Furthermore, real-time observation using high-speed atomic force microscopy revealed highly mobile features of the CDV-H dimeric head via the connector region. These results suggest that sugar-shielded tilted-homodimeric structure and dynamic conformational changes are common characteristics of morbilliviruses and ensure effective fusion entry and vaccination.
Small deviations in kinematics and body form dictate muscle performances in the finely tuned avian downstroke
Authors: Deetjen Marc E. , Chin Diana D. , Heers Ashley M. , Tobalske Bret W. , Lentink David
Published: December 2023

Avian takeoff requires peak pectoralis muscle power to generate sufficient aerodynamic force during the downstroke. Subsequently the much smaller supracoracoideus recovers the wing during the upstroke. How the pectoralis work loop is tuned to power flight is unclear. We integrate wingbeat-resolved muscle, kinematic and aerodynamic recordings in vivo with a new mathematical model to disentangle how the pectoralis muscle overcomes wing inertia and generates aerodynamic force during takeoff in doves. Doves reduce the angle of attack of their wing mid-downstroke to efficiently generate aerodynamic force, resulting in an aerodynamic power dip, that allows transferring excess pectoralis power into tensioning the supracoracoideus tendon to assist the upstroke—improving the pectoralis work loop efficiency simultaneously. Integrating extant bird data, our model shows how the pectoralis of birds with faster wingtip speed need to generate proportionally more power. Finally, birds with disproportionally larger wing inertia need to activate the pectoralis earlier to tune their downstroke.

Ecology

Doves improve their wingbeat efficacy without elevating maximum pectoralis power by angling their wings mid-downstroke to efficiently generate aerodynamic force while simultaneously tensioning the supracoracoideus tendon to assist the upstroke.
Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Authors: Mure Ayumi , Sugiura Yuki , Maeda Rae , Honda Kohei , Sakurai Nozomu , Takahashi Yuuki , Watada Masayoshi , Katoh Toshihiko , Gotoh Aina , Gotoh Yasuhiro , Taniguchi Itsuki , Nakamura Keiji , Hayashi Tetsuya , Katayama Takane , Uemura Tadashi , Hattori Yukako
Published: December 2023

Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed and isolated microbes from natural food sources of
Drosophila
larvae, and investigated their functions.
Hanseniaspora uvarum
is the predominant yeast responsible for larval growth in the earlier stage of fermentation. As fermentation progresses,
Acetobacter orientalis
emerges as the key bacterium responsible for larval growth, although yeasts and lactic acid bacteria must coexist along with the bacterium to stabilize this host-bacterial association. By providing nutrients to the larvae in an accessible form, the microbiota contributes to the upregulation of various genes that function in larval cell growth and metabolism. Thus, this study elucidates the key microbial species that support animal growth under microbial transition.
Serotonergic amplification of odor-evoked neural responses maps onto flexible behavioral outcomes
Authors: Bessonova Yelyzaveta , Raman Baranidharan
Published: December 2023

Behavioral responses to many odorants are not fixed but are flexible, varying based on organismal needs. How such variations arise and the role of various neuromodulators in achieving flexible neural-to-behavioral mapping is not fully understood. In this study, we examined how serotonin modulates the neural and behavioral responses to odorants in locusts (Schistocerca americana). Our results indicated that serotonin can increase or decrease appetitive behavior in an odor-specific manner. On the other hand, in the antennal lobe, serotonergic modulation enhanced odor-evoked response strength but left the temporal features or the combinatorial response profiles unperturbed. This result suggests that serotonin allows for sensitive and robust recognition of odorants. Nevertheless, the uniform neural response amplification appeared to be at odds with the observed stimulus-specific behavioral modulation. We show that a simple linear model with neural ensembles segregated based on behavioral relevance is sufficient to explain the serotonin-mediated flexible mapping between neural and behavioral responses.
Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome
Authors: Shakhawat Amin Md , Foltz Jacqueline G , Nance Adam B. , Bhateja Jaydev , Raymond Jennifer L
Published: December 2023

The enhancement of associative synaptic plasticity often results in impaired rather than enhanced learning. Previously, we proposed that such learning impairments may result from saturation of the plasticity mechanism making it unavailable to be recruited at the appropriate synapses to support learning (Nguyen-Vu et al., 2017). This hypothesis was based on experimental results from mice lacking two class I major histocompatibility molecules, MHCI H2-K
b
and H2-D
b
(MHCI
K

b

D

b−/−

), which have enhanced associative long-term depression at the parallel fiber-Purkinje cell synapses in the cerebellum (PF-Purkinje cell LTD). Here we extend this work by testing predictions of the saturation hypothesis in a second mouse line with enhanced PF-Purkinje cell LTD, the
Fmr1
knockout mouse model of Fragile X syndrome (FXS). Mice lacking
Fmr1
gene expression in cerebellar Purkinje cells (L7-
Fmr1
KO) were selectively impaired on an oculomotor learning task in which PF-Purkinje cell LTD has been implicated, with no impairment on an LTD-independent oculomotor learning task. Consistent with the saturation hypothesis, behavioral pre-training designed to reverse LTD at the PF-Purkinje cell synapses eliminated the oculomotor learning deficit in the L7-
Fmr1
KO mice, as previously reported in MHCI
K

b

D

b−/−

mice. In addition, diazepam treatment to suppress neural activity and thereby limit the induction of associative LTD during the pre-training period also eliminated the learning deficit in L7-
Fmr1
KO mice. These results support the hypothesis that the enhancement of synaptic plasticity can lead to its saturation
in vivo
and inability to support learning, providing a novel mechanistic perspective that could inform the development of new clinical approaches for autism and other disorders of the nervous system.
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs
Authors: Li Yi-Hong , Yang Yi-Sen , Xue Yan-Bo , Lei Hao , Zhang Sai-Sai , Qian Junbin , Yao Yushi , Zhou Ruhong , Huang Liquan
Published: December 2023

Tuft cells are a group of rare epithelial cells that can detect pathogenic microbes and parasites. Many of these cells express signaling proteins initially found in taste buds. It is, however, not well understood how these taste signaling proteins contribute to the response to the invading pathogens or to the recovery of injured tissues. In this study, we conditionally nullified the signaling G protein subunit
G
γ
13
and found that the number of ectopic tuft cells in the injured lung was reduced following the infection of the influenza virus H1N1. Furthermore, the infected mutant mice exhibited significantly larger areas of lung injury, increased macrophage infiltration, severer pulmonary epithelial leakage, augmented pyroptosis and cell death, greater bodyweight loss, slower recovery, worsened fibrosis and increased fatality. Our data demonstrate that the
G
γ
13
-mediated signal transduction pathway is critical to tuft cells-mediated inflammation resolution and functional repair of the damaged lungs.To our best knowledge, it is the first report indicating subtype-specific contributions of tuft cells to the resolution and recovery.
The evolution of transposable elements in Brachypodium distachyon is governed by purifying selection, while neutral and adaptive processes play a minor role
Authors: Horvath Robert , Minadakis Nikolaos , Bourgeois Yann , Roulin Anne C.
Published: December 2023

Understanding how plants adapt to changing environments and the potential contribution of transposable elements (TEs) to this process is a key question in evolutionary genomics. While TEs have recently been put forward as active players in the context of adaptation, few studies have thoroughly investigated their precise role in plant evolution. Here we used the wild Mediterranean grass
Brachypodium distachyon
as a model species to identify and quantify the forces acting on TEs during the adaptation of this species to various conditions, across its entire geographic range. Using sequencing data from more than 320 natural
B. distachyon
accessions and a suite of population genomics approaches, we reveal that putatively adaptive TE polymorphisms are rare in wild
B. distachyon
populations. After accounting for changes in past TE activity, we show that only a small proportion of TE polymorphisms evolved neutrally (< 10%), while the vast majority of them are under moderate purifying selection regardless of their distance to genes. TE polymorphisms should not be ignored when conducting evolutionary studies, as they can be linked to adaptation. However, our study clearly shows that while they have a large potential to cause phenotypic variation in
B. distachyon
, they are not favored during evolution and adaptation over other types of mutations (such as point mutations) in this species.
Combination of serum CST1 and HE4 for early diagnosis of endometrial cancer
Authors: Zhong Wenhui , Liu Yunliang , Zhang Liangming , Zhuang Wanzhen , Chen Jianlin , Huang Zhixin , Zheng Yue , Huang Yi
Published: December 2023

Purpose

Optimal serological biomarkers have been absent for the early diagnosis of endometrial cancer, to date. In this study, we aimed to define the diagnostic performances of individual and combined detection of serum cysteine protease inhibitor 1 (CST1) with traditional tumor markers, including glycated antigen 125 (CA125) and human epididymis protein 4 (HE4), in patients with early-stage endometrial cancer (EC).

Methods

The performances of individual and combined detection of serum CST1, HE4, and CA125 were evaluated by enzyme-linked immunosorbent assay (ELISA) and chemiluminescent immunoassay, respectively. A training data set of 67 patients with early EC, 67 patients with endometrial benign lesion (EBL), and 67 healthy controls (HC) was used to develop a predictive model for early EC diagnosis, which was validated by an independent validation data set.

Results

In the training data set, serum CST1 and HE4 levels in the early EC group were significantly higher than in EBL/HC groups (P < 0.05), while there was no significant difference of serum CA125 level between the early EC and EBL/HC groups (P > 0.05). Serum CST1 and HE4 exhibited areas under the curve (AUC) of 0.715 with 31.3% sensitivity at 90.3% specificity, and 0.706 with 23.9% sensitivity at 95.5% specificity, respectively. Combined detection of serum CST1 and HE4 exhibited an AUC of 0.788 with 49.3% sensitivity at 92.5% specificity. The combination of serum CST1 and HE4 showed promise in diagnosis.

Conclusion

CST1 is a prospective serological biomarker for early EC diagnosis, and the combination of CST1 and HE4 contributes to the further improvement in the diagnosis of patients with early-stage EC.
Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing the transcription and splicing of tumorigenesis-related genes
Authors: Sun Qingchao , Liu Ruixue , Zhang Haiping , Zong Liang , Jing Xiaoliang , Ma Long , Li Jie , Zhang Liwei
Published: December 2023

Background

High mortality rates are prevalent among patients with non-small-cell lung cancer (NSCLC), and effective therapeutic targets are key prognostic factors. Fascin actin-bundling protein 1 (FSCN1) promotes NSCLC; however, its role as an RNA-binding protein in NSCLC remains unexplored. Therefore, we aimed to explore FSCN1 expression and function in A549 cells.

Method

We screened for alternative-splicing events and differentially expressed genes (DEGs) after FSCN1 silence via RNA-sequencing (RNA-seq). FSCN1 immunoprecipitation followed by RNA-seq were used to identify target genes whose mRNA expression and pre-mRNA alternative-splicing levels might be influenced by FSCN1.

Results

Silencing FSCN1 in A549 cells affected malignant phenotypes; it inhibited proliferation, migration, and invasion, and promoted apoptosis. RNA-seq analysis revealed 2,851 DEGs and 3,057 alternatively spliced genes. Gene ontology-based functional enrichment analysis showed that downregulated DEGs and alternatively splicing genes were enriched for the cell-cycle. FSCN1 promoted the alternative splicing of cell-cycle-related mRNAs involved in tumorigenesis (i.e., BCCIP, DLGAP5, PRC1, RECQL5, WTAP, and SGO1). Combined analysis of FSCN1 RNA-binding targets and RNA-seq data suggested that FSCN1 might affect ACTG1, KRT7, and PDE3A expression by modulating the pre-mRNA alternative-splicing levels of NME4, NCOR2, and EEF1D, that were bound to long non-coding RNA transcripts (RNASNHG20, NEAT1, NSD2, and FTH1), which were highly abundant. Overall, extensive transcriptome analysis of gene alternative splicing and expression levels was performed in cells transfected with FSCN1 short-interfering RNA. Our data provide global insights into the regulatory mechanisms associated with the roles of FSCN1 and its target genes in lung cancer.
Proposição de diretrizes para a implementação de novas tecnologias na Polícia Técnico-Científica de Goiás
Authors: Bousquet Hesther de Macedo , Poltronieri Camila Fabrício , Yamanaka Lie , Do Amaral Tatiana Gondim
Published: December 2023

A implementação de novas tecnologias é um desafio nas mais diversas organizações. Enquanto muitos estudos têm sido conduzidos para analisar as dificuldades enfrentadas por empresas privadas na implementação de inovações tecnológicas, é essencial reconhecer que as organizações públicas enfrentam dificuldades únicas e distintas que impactam a sua capacidade de aceitar e utilizar efetivamente novas tecnologias. A implementação bem-sucedida de novas tecnologias em instituições de ciências forenses é um tópico de extrema relevância, dada a importância crítica dessas instituições na busca pela verdade e justiça nos sistemas jurídicos. Desta forma, este trabalho visa identificar as principais causas de dificuldades de implementação de novas tecnologias de forma unificada e efetiva na Polícia Técnico-Científica de Goiás. Para a identificação das causas foram realizados dois brainstormings com servidores da instituição e, ainda, foram utilizados alguns insights fornecidos por servidores em uma consulta institucional. A partir dos brainstormings, as causas elencadas foram priorizadas quanto à importância de resolução e quanto à facilidade de resolução, utilizando escala Likert de 1 a 5 e foram realizados os planos de ação das 4 causas que apresentaram maior pontuação, utilizando a ferramenta 5W1H. Os resultados foram discutidos à luz da literatura e trazem insights valiosos para a implementação de novas tecnologias, tanto em instituições forenses quanto em outras organizações do setor público.
Examination of the effect of curcumin supplementation on liver enzymes and some physiological parameters in volleyball players
Authors: Ayhan Savaş , Erdoğan Ramazan , Tizar Ercan , Tizar Gönül Rezzan , Kavuran Korhan
Published: December 2023

Purpose: The aim of this study is to examine the effect of curcumin supplementation applied in addition to volleyball training on the lipid metabolism and some physiological parameters of the athletes. Material Method: The research group consisted of 20 volunteer male volleyball athletes who consistently participated in training and national level volleyball events. In addition to volleyball exercise, the participants in the research received 200 mg of curcumin pill. During the volleyball competition time, the research group received an 85-minute daily training regimen three days a week for six weeks. Findings: When the biochemical parameters of the athletes of the research group were analyzed as a result of the training, it was determined that there was a statistically significant difference in the glucose, creatine, pre-test and post-test levels (p<0.05), while there was no statistically significant difference in the sub-pretest-posttest level (p>0.05). It was determined that there was a statistically significant difference between lipid metabolism, triglyceride pre-test and post-test levels (p<0.05), while there was not statistically significant difference found between pre-post-test values for total cholesterol levels (p>0.05). Result: It has been observed that curcumin supplementation applied in addition to volleyball training affects the lipid metabolism and physiological parameters of the athletes. In line with this information, we believe that the supplements to be applied in addition to their routine training will positively affect the athletic performance of the athletes.
ENSINO DE CIÊNCIAS E BIOLOGIA PARA ALUNOS COM TRANSTORNO DO ESPECTRO DO AUTISMO SOB A PERSPECTIVA DOS PROFESSORES
Authors: De  Paula Nunes Debora Regina , Nascimento Maria santa Borges do
Published: December 2023

As demandas de aprendizagem dos alunos com Transtorno do Espectro do Autismo (TEA) nem sempre são consideradas na implementação do currículo acadêmico regular. No caso das disciplinas de ciências, essa tendência é atribuída a limitações que muitos desses educandos apresentam na transposição da linguagem científica para o cotidiano. O objetivo da presente investigação foi descrever, através de uma pesquisa de levantamento, as estratégias de ensino de Ciências/Biologia utilizadas por treze professores de alunos com TEA, de escolas públicas do Ceará e do Rio Grande do Norte. Os dados, produzidos a partir de questionários eletrônicos e entrevistas, revelaram convergências com algumas práticas descritas na literatura, limitado uso de estratégias empiricamente validadas e conhecimento restrito sobre as demandas educacionais de alunos com TEA.
TRANSTORNO DO ESPECTRO AUTISTA
Authors: Da Silva Raimunda Leila José , Caixeta Juliana Eugênia , Gauche Ricardo
Published: December 2023

Este artigo discute o Atendimento Educacional Especializado para estudantes com Dupla Excepcionalidade na Rede Pública do Distrito Federal. A realização desta pesquisa é relevante devido à escassez de pesquisas sobre a temática e, também, pela contradição entre a legislação brasileira e os resultados recentes de pesquisas científicas sobre como deve ser o AEE para estudantes com DE. A pesquisa é de abordagem qualitativa, os/as participantes da pesquisa foram três professores/as especialistas atuantes em nas Salas de Recursos Específicas para Altas Habilidades/Superdotação no Distrito Federal. Os dados foram analisados à luz da Análise de Conteúdo de Bardin (2009). Os resultados sugerem a necessidade de um atendimento educacional especializado concomitante de suplementação e de complementação e não separado, como tem sido feito no Distrito Federal.
INTERVENÇÃO PRECOCE PARA CRIANÇAS COM TRANSTORNO DO ESPECTRO AUTISTA:
Authors: Moraes Louriane Lindoso , Nascimento da Silveira Rosa Kaciana , Zaqueu Lívia Da Conceição Costa , Franco Vitor Daniel Ferreira
Published: December 2023

O estudo tem por objetivo mapear trabalhos realizados no âmbito de dissertações e teses brasileiras que abordam a temática da intervenção precoce em crianças com Transtorno do Espectro Autista (TEA), na faixa etária de 0 a 6 anos de idade. Para isso, realizou-se o estado da questão. O levantamento bibliográfico foi realizado no Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior -CAPES - no período de publicação entre 2018-2022. Foram encontrados 8 trabalhos. Os resultados demonstraram a importância da identificação e intervenção precoce do Transtorno do Espectro Autista; a necessidade de formação dos profissionais que atuam com crianças com TEA, em conformidade com suas necessidades e atuação prática; e a importância de considerar a participação da família durante a realização das intervenções.
APRESENTAÇÃO
Authors: Leal Daniela , Nascimento da Silveira Rosa Kaciana
Published: December 2023

Objetiva-se com a temática desta seção especial, Transtorno do Espectro Autista: do olhar estigmatizante à construção da condição humana, apresentar trabalhos/pesquisas que transcendam a construção do conceito de TEA como deficiência, doença e/ou transtorno, e ampliem a compreensão da pessoa com TEA como ser em processo de construção, reconhecida em sua condição humana, com potencialidades e limitações. Isso permite ampliar o olhar para o desenvolvimento da mesma, por meio de um processo educativo intencional que se adiante ao seu desenvolvimento e garanta a apropriação de instrumentos intelectuais e materiais promovendo, com isso, o acesso e a permanência dessas aos espaços sociais, em especial às instituições de ensino.
Distribution of Blue Swim Crab (Portunus pelagicus) Catching Areas Using Foldable Traps in the Coastal Waters of Barru Regency, Indonesia
Authors: Adam  , Hasmawati  , Husniati
Published: December 2023

The utilization of blue swim crab resources poses a significant challenge that requires appropriate solutions, thus necessitating effective resource management. Uncontrolled fishing conditions can lead to economic overfishing if proper management is not implemented. Moreover, fishermen compete to increase their fishing efforts, leading to the need for capturing in more distant areas. Therefore, rehabilitation and management actions need to be promptly executed. This study aims to analyze blue swim crab catching areas based on distance from the coast, crab weight, carapace width, size of adult crabs, and the size of crabs eligible for capture in the coastal waters of Barru Regency. The research was conducted over 8 months, from May to December 2022, in the blue swim crab fishing grounds in the waters of Barru Regency, South Sulawesi Province. Data Was collected through a combination of survey and observation methods. The collected data were descriptively analyzed SPSS and Microsoft Excel programs. The results indicate that: (1) Constituted 51.8% of the captured individuals, and females constituted the remaining 48.2%; (2) The average weight and carapace width of these crabs fluctuated based on the distance and depth of the fishing areas; (3) A higher number of adult-sized crabs were caught in the crab catching areas at a distance of 3-5 nautical miles from the coast; (4) The percentage of adult crabs was larger compared to crabs eligible for capture, indicating symptoms of overfishing; (5) All the individuals were of mature size. Specifically, 88.9% for male crabs and 94.3% for female crabs. The criteria used to determine eligibility for capture were carapace width above 11 cm.
Acute and Sub-chronic Toxicity Evaluation of the Ethanolic Extract of Coula edulis B., (Olacaceae) Stem Bark
Authors: Beyegue Eric , Youovop Janvier Fotso , Takuissu Guy Roussel , Ndoue Nadine Essola , Mbappe Florine Essouman , Edou Ferdinand , Azantsa Boris Gabin Kingue , Ngondi Judith Laure , Oben Julius Enyong
Published: December 2023

Aims: Coula edulis Baill., (Olacaceae) is a non-lignified forest product not well known and widely used in sub-Saharan Africa as a phytomedicine or food additive. However, the toxicity of this plant remains unknown. This study aimed to assess the safety of the ethanolic extract of C. edulis stem bark (CEE).

Study Design:  Pharmacological study.

Place and Duration of Study: Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1 (Cameroon), between June 2018 and July 2022.

Methodology: Studies on the assessment of acute and subchronic toxicity were carried out by guidelines 423 of the Organization for Economic Co-operation and Development (OECD). Subacute toxicity of the sample was assessed over 28 days using repeated doses by OECD Guideline 407.

Results: No cases of death and clinical signs of toxicity were observed in the treated rats, suggesting that the LD50 of C. edulis ethanolic extract is greater than 2000 mg/kg bw. Regarding the subacute toxicity study, the administration of CEE also did not result in any changes in the course of body weight. Only a significant decrease in the relative weight of the ovaries in females at the highest dose of 600 mg/kg was observed. In males and females, CEE did not affect lipid profile markers or transaminase levels (AST, ALT). In addition, a small but non-significant (p> 0.05) increase in creatinine was observed without kidney dysfunction. In males, CEE induced an increase in mean corpuscular volume number at 600 mg/kg, while at the same time, mean corpuscular hemoglobin concentration decreased at the 300 mg/kg dose. In females, a significant increase in the number of monocytes, red blood cells, and hemoglobin level were observed. No difference in the levels of urea, glucose, and lipid markers was observed nor histological changes in the organs studied.

Conclusion: As would be expected, exposure to CEE did not cause significant toxic effects in treated rats. Therefore, this plant extract can be safely recommended for therapeutic use.
The Evolutionary Theory along the Phylogenetic Tree of Unicellular Organisms
Authors: Otsuka Jinya
Published: December 2023

In parallel to the advancement of molecular biology suggesting the evolutionary route from the RNA world to the DNA-RNA-protein world through the RNA-protein world, the analysis on the nucleotide base changes in ribosomal RNA genes revels that the divergence of prokaryote and eukaryote first occurred in the DNA-RNA-protein world but the divergence of present-day lineages in eukaryotes occurred after the ancestral eukaryote has acquired the mitochondria as the endosymbionts of O2-respiratory eubacteria. These results strongly suggest that the divergence of unicellular organisms is closely related with the drastic changes in cell contents such as the formation of ribosome, the generation of RNA genes, the conversion from the RNA genes to DNA genes, gene duplication or the endosymbiosis. In the present paper, such drastic changes in evolution of unicellular organisms are theoretically formulated on the basis of the concept of biological activity which consists of the acquired energy, stored energy and systematization. Upon the drastic change in cell contents, the biological activity of an organism is first lowered by the increase in stored energy, but it is gradually recovered as the systematization advances to increase the acquired energy overcoming the increased stored energy and negative entropy due to the systematization itself. Throughout this process, the divergence of new style organisms occurred utilizing new material and energy sources. Such evolutionary process will be explained in detail at the main divergence points in the phylogenetic tree. The relation of such drastic changes in evolution with Darwinian evolution is also clarified.
Radiative Forcing and Climate Sensitivity of Carbon Dioxide (CO2) Fine-tuned with CERES Data
Authors: Ollila Antero
Published: December 2023

An updated effective radiative forcing (ERF) value for constructing a simplified logarithmic forcing equation, and a transient climate response (TCR) value, are presented for CO2, CH4, and N2O. The results are based on line-by-line (LBL) calculations utilizing the HITRAN database and the CERES radiation flux data for fine-tuning. The ERF value derived when doubling the CO2 concentration from 280 ppm (2xCO2) is 2.65 Wm-2 which is in line with the instantaneous radiative forcing (IRF) values of climate models referred to by the IPCC. The difference between the ERF values comes from the stratospheric cooling effect. It is a question about an essential paradigm change of the IPCC approach. In the former 2xCO2 value of 3.7 Wm-2, its portion was about 5 %, and in the present value, it is about 30 %. According to this study, the same effect is 10 %. The updated TCR value is 0.7 ±0.15 °C.
Effect of Organic Nutrients and Bio Fertilizers on Soil Parameters and Nutritional Content of Amaranth
Authors: Sarangi Swati Sulagna , Sarma Ira , Gogoi Sailen , Barooah Aradhana
Published: December 2023

A field experiment was conducted to study the effect of organic nutrients and bio fertilizers on soil parameters and nutritional content of amaranth. Eleven treatments were taken in three replications and the experiment was conducted in a randomized block design (RBD).The treatments were T1:RDF (60:30:20 kg NPK/ha), T2:Vermicompost @ 2 t/ha, T3:Vermicompost @ 5 t/ha, T4:FYM 10 t/ha, T5:FYM 20t/ha, T6:Poultry manure 3t/ha, T7:Poultry manure 5 t/ha, T8:Vermicompost @ 2 t/ha+PSB+Azospirillum@ 5 kg/ha each, T9 :FYM @ 10t/ha+ PSB+Azospirillum@ 5 kg/ha each, T10:Poultry manure 3 t/ha+ PSB+Azospirillum@ 5 kg/ha each and T11:  Untreated control. The highest vitamin C (147.8 mg/100 gm) and crude fibre content (1.48%) was observed in the treatment T8 and T4, respectively. Maximum calcium (8.36%) and iron (0.21%) content was observed in the treatment T8. The treatment T10 recorded the highest mean performance for PH, organic carbon, available nitrogen and potash content in the soil analyzed after harvest of the crop.
Comparative Study on Impact of Mating Systems on Character Associations in Single Crosses of Maize (Zea mays L.)
Authors: Priya P. Bindu , Pradeep T. , Sumalini K. , Reddy D. Vishnu Vardhan , Supriya K.
Published: December 2023

Although global maize breeding programmes are in momentum with high number of superior hybrids releasing annually, the full potential of hybrids is seldom achieved in real time due to various biotic and abiotic stresses. It is pertinent to broaden the diversity of available germplasm to suit to the needs of present changing climatic conditions. In this study, six segregating populations of two maize single crosses developed by imposing three types of matings (self, sib and random mating) were evaluated to assess their potential in future breeding programmes. Trait association studies were conducted in these populations to estimate the success rate of selections, time required to develop superior inbreds and assist in parental choice for hybrid development programmes. Results indicated that sib mating was the most effective among the three mating systems, as its progeny showed highest number of significant positive correlations among the yield and its related traits. Selfed progenies exhibited lesser number or weak positive correlations while random mating largely resulted in negative and weak positive correlations.
Two Years Outcome of Laparoscopic Sleeve Gastrectomy in Obese Patients in A Government Hospital of Central India (2017-2019) with Review of Literature
Authors: Bansod Atish , Mirajkar Girish , Jadhav Vaishnavpriya K. , Wankhede Abhijit M. , Kothari Kathan
Published: December 2023

Background: Bariatric surgery is an established mode of weight loss which has metabolic effects in addition to weight loss. Laparoscopic sleeve gastrectomy is a restrictive procedure which entails creation of gastric sleeve laparoscopically by using laparoscopic staplers.

Materials and Methods: The present study was carried out in the Department of Surgery in Government Medical College and Hospital on 50 patients admitted in different surgical wards from July 2017 to November 2019. They were evaluated for weight loss and co-morbidity resolution in addition to studying the clinical profile.

Objectives: To study the safety and effectiveness of the sleeve gastrectomy as a bariatric procedure

Results: The mean age of participants in this study is 38.8 years. The youngest participant is 18 years old. The oldest participant is 58 years old. The male to female sex ratio is 1:1.94. Out of 50 (22%) patients belonged to the middle class and remaining 39 out of 50 patients (78%) belonged to the lower socioeconomic scale according to 2019 revised Kuppuswamy scale. The lowest Body Mass Index (BMI) operated was 33 kg/m2. The mean BMI operated was 38.81 kg/m2. The most common group of patients belonged to the group of BMIs between 35-39.9kg/m2. %EWL at 2 years is 81.83. Percentage of complete resolution of DM, HTN, OSA and hypothyroidism is 61.53%, 70.59%, 90% and 66.67%.

Conclusions: Laparoscopic sleeve gastrectomy is a safe and effective form of bariatric surgery with comparable weight-loss and co-morbidity resolution.
Effect on Vegetative Growth and Economic Feasibility of Potato (Solanum tuberosum L.) cv. Kufri Bahar through Foliar Spray of Bulk Chlorocholine Chloride (CCC) & Nano CCC
Authors: Tak Jitendra Kumar , Pilania Shalini , Lakhawat S. S. , Kaushik R. A. , Mahawer L. N. , Singh Virendra , Sharma Latika , Intodia S. K.
Published: December 2023

A field experiment consisting 12 treatments having 3 replications was carried out from November (2020-21 & 2021-22) at Rajasthan College of Agriculture, Udaipur (Rajasthan) to asses’ economic feasibility of chlorocholine chloride (CCC) and Nano CCC on potato. CCC-CS NFs (0.04, 0.08, 0.12, 0.16 and 0.20% w/v), CCC (0.04, 0.08, 0.16, 0.20% w/v), bulk chitosan (BCH 0.01% w/v) and control (water) were applied through foliar application at tuber initiation at 25th day and tuber bulking at 45thdays. Pooled data of two years showed that CCC-CS NFs (0.20%) got maximum net return (Rs. 267005.90) and maximum leaves/plant followed by 0.16% CCC-CS NFs (386 leaves) as comparative to rest of treatments. Non-significant difference in leaf area was recorded in all concentration of CCC-CS NFs, CCC, BCH and control.