bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalencia de fatiga pos-COVID-19 en pacientes de la Unidad de Medicina Familiar (UMF) N.° 1, Aguascalientes
Authors: Villagrana González Georgina Lizeth , Ruelas De León Grecia Yurai
Published: April 2024

Introducción: La fatiga es el síntoma de mayor prevalencia en los pacientes pos-COVID, afectando su calidad de vida. Objetivo: Calcular la prevalencia de fatiga pos-COVID-19 que se presenta en pacientes mayores de 18 años adscritos a la Unidad de Medicina Familiar N.° 1 del Instituto Mexicano del Seguro Social (IMSS), Aguascalientes. Métodos: La investigación fue observacional, descriptiva, transversal, simple. Se aplicó la Escala de Impacto de Fatiga de 10 reactivos a 384 pacientes mayores de 18 años adscritos a la UMF N.° 1 confirmados de COVID-19 previo 6-12 meses. Dichos datos fueron analizados por medio del Statistical Package for the Social Sciences (SPSS) 21. Resultados: La muestra consistió principalmente en mujeres (62%), edad promedio de 40.5 años, y tendencia hacia la educación superior, con 63% teniendo al menos una licenciatura. Se identificaron desafíos en diversas áreas con 46.7% enfrentando dificultades para satisfacer demandas externas y 52.6% experimenta más estrés cotidiano. Además, 35.4% siente incapacidad para brindar adecuado apoyo emocional a su familia. En aspectos cognitivos, 56.5% presenta falta de claridad mental y 37.0% dificultades en mantener la atención. Respecto a la fatiga física, 33.6% ha moderado el ritmo de sus actividades y 43.7% muestra menor motivación para esfuerzos físicos tras recuperarse de la enfermedad. Conclusiones: La prevalencia de fatiga pos-COVID-19 estuvo presente en 10% de los participantes, se registró afectación en diferentes dimensiones de esta escala, lo que indica que la fatiga pos-COVID tiene un impacto significativo en varios aspectos de la vida de los individuos recuperados.
Recepción: 08/02/2024Aprobación: 18/02/2024
NMR proven albumin interaction with metabolites in complex mixtures
Authors:   “Costin D. Nenitescu” Institute of Organic and Supramolecular Chemistry, Roumanian Academy, Spl. Independentei 202B, Bucharest RO-060023, Roumania, DUDUIANU Cătălin , NICOLESCU Alina ,   “Costin D. Nenitescu” Institute of Organic and Supramolecular Chemistry, Roumanian Academy, Spl. Independentei 202B, Bucharest RO-060023, Roumania, CRISTEA Mihaela ,   “Petru Poni” Institute of Macromolecular Chemistry, Roumanian Academy, Aleea Grigore Ghica Voda 41A, Iasi RO-700487, Roumania, STAN Raluca ,   Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 011061 Bucharest, Roumania, DELEANU Calin ,   “Costin D. Nenitescu” Institute of Organic and Supramolecular Chemistry, Roumanian Academy, Spl. Independentei 202B, Bucharest RO-060023, Roumania
Published: April 2024

One critical step in new drugs development is the investigation of the interactions between drug candidate and target protein. Nuclear Magnetic Resonance Spectroscopy (NMR) is a well-established technique for studding these interactions.
Due to its availability and structural similarities to human albumin, bovine serum albumin (BSA) is widely accepted as a model for investigating the binding of small molecules to serum albumin. We report here on the evaluation of binding interactions between BSA and 18 metabolites using saturation transfer difference (STD) NMR experiments.
Positive STD signals that indicate metabolite-protein interactions were obtained for leucine, pyruvic acid, valine, threonine, alanine, 4-aminohippuric acid and tryptophan.
Rheumatoid Arthritis and T-Cell Large Granular Lymphocyte Leukemia: A Description of the Clinical Case
Authors:   International Office, State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russiа, Praskurnichiy E.A. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Badykova K.M. ,   International Office, State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russiа, Kitaeva Ju.S. ,   International Office, State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russiа
Published: April 2024

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting the musculoskeletal system. Neutropenia often develops in RA, the pathogenesis of which is currently insufficiently studied. One of the causes of severe neutropenia may be a hematological disease, namely T-cell large granular lymphocyte leukemia (LGL). A third of patients with RA are also diagnosed with LGL, which is due to a similar pathogenetic mechanism. The clinical picture is very diverse and insufficiently specific, which causes difficulties in making a diagnosis. The purpose of this work was to analyze the features of the management of a patient with rheumatoid arthritis combined with T-cell leukemia from large granular cells. A patient born in 1953 with a long history of RA without special treatment was hospitalized in the hematology department with complaints of severe weakness, manifestations of hemorrhagic syndrome. The general blood test revealed severe anemia, leukopenia with agranulocytosis and thrombocytopenia. The patient underwent additional instrumental examinations. Substitution therapy was performed with a positive effect. In this case, peripheral blood immunophenotyping was not performed and the diagnosis was based on trepanobiopsy. According to the immunohistochemical study, leukemia from large granular T-lymphocytes was diagnosed, and therefore the patient receives treatment according to national clinical guidelines. Diagnosis of T-LGL is an urgent issue due to the frequent combination with RA, which indicates the need for a thorough differential diagnosis of neutropenia in this category of patients.
Respecting dignity: A fundamental element of the ethical being's existence
Authors: Chakar Ljupcho , Stankov Aleksandar , Pavlovski Goran , Bitoljanu Natasha , Belakaposka Srpanova Viktorija , Ivcheva Ana , Siamkouri Rosica , Jakovski Zlatko
Published: April 2024

Human dignity is a pivotal concept in contemporary ethical, political, and legal discourse. However, divergent and sometimes conflicting interpretations of human dignity contribute to confusion across various discussions. Given that all human beings possess inherent moral potential, each individual is endowed with universal dignity. The extent to which people develop their moral potential varies.
Discussing an individual’s dignity, as in other medical specialties, cannot be separated from forensic medicine as a distinct medical discipline. In conclusion, the authors assert that establishing medical facts, or the truth ascertained through expert examination, serves justice by ensuring dignified treatment of the deceased, their family, and relatives.

Keywords: dignity, ethics, forensic medicine, human remains
Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with chronic myeloid leukemia treated with imatinib
Authors: Labachevski Bojan , Zendelovska Dragica , Petrushevska Marija , Popova-Labachevska Marija , Pivkova-Veljanovska Aleksandra , Gjatovska-Labachevska Liljana , Ridova Nevenka , Trajkova Sanja , Panovska-Stavridis Irina , Balkanov Trajan
Published: April 2024

Antioxidant status in patients with chronic myeloid leukemia (CML) is significantly decreased in comparison with healthy individuals. Oxidative stress (OS) may be associated with the pathophysiology of CML and can influence on development of resistance to imatinib.
The aim of our study was to investigate the effect of Aronia melanocarpa extract (A-lixir 400 PROTECT®) on OS in CML patients treated with imatinib.
In this study a total of 40 CML patients treated with imatinib for longer than 1 month were included: twenty patients were treated with imatinib and A-Lixir 400 PROTECT® (treatment group) and twenty patients were treated only with imatinib (control group). OS parameters (d-ROM, PAT and OSI) were measured at the initial visit, and after 21 and 42 days of treatment. Adjuvant treatment with A-Lixir 400 PROTECT® could lead to attenuation of OS. d-ROM and OSI in this group of patients were significantly higher at initial visit when compared to values after 21 and 42 days of treatment (p<0.05). Total antioxidant capacity (PAT) was significantly higher after 21 and 42 days of treatment initiation in comparison with the pretreatment values. In the control group no significant differences were obtained between investigated parameters at any time of measurement. We can conclude that adjuvant treatment with A-Lixir 400 PROTECT® after 21 and 42 days lead to significant reduction of OS in patients with CML treated with imatinib.
Keywords: Oxidative stress, d-ROM, PAT, OSI, chronic myeloid leukemia, imatinib, Aronia melanocarpa
Analisis Sentimen Komentar Youtube Terhadap Tayangan #Terbaru! Temuan dan Masalah Ahlak Di Ponpes Al-zaytun Menggunakan Metode Naïve Bayes
Authors: Ansyah Mochammad Febrialdi , Ghofur Abd. , Lidimillah Lukman Fakih
Published: April 2024

Cara mengetahui umpan balik dari konten di sosial media adalah dengan cara melihat komentar yang diutarakan oleh masyarakat. Hal ini bisa dipelajari melalui salah satu cabang ilmu teknologi komputer yaitu text mining. Dengan teks mining tersebut kita dapat menggali informasi dari data komentar. Analisis sentimen merupakan solusi dalam mengelompokkan respon masyarakat dalam bentuk komentar kedalam komentar positif, netral dan negatif. Dari channel youtube iNews menayangkan salah satu videonya tentang pondok pesantren Al-Zaytun. pada tayangan tersebut dapat diperoleh informasi dari data yang tidak terstruktur sehingga diperlukan suatu metode dalam mengelompokkan data komentar  dalam komentar yang positif, netral dan negatif. Pada analisis sentimen ini akan menggunakan pengklasifikasian menggunakan metode naïve bayes. Naïve bayes merupakan metode yang sederhana namun tingkat akurasinya baik di dalam proses klasifikasi. Pengujian tersebut mendapatkan nilai akurasi 64%, recall 93%, Precision 75% dengan ini dapat disimpulkan bahwa metode naïve bayes cocok digunakan dalam analisis sentiment pada komentar youtube.
Designing UI/UX Thrift shop Website Using User Centered Design (UCD) Method (Case Study: Backfold Market)
Authors: Firmansyah Bachtiar , Inan Dedi I. , Juita Ratna , Sanglise Marlinda
Published: April 2024

Backfold is a second-hand clothing business in Manokwari city that conventional operates with sales requiring customers to visit the store to make purchases. Therefore, a user interface and user experience website were created to facilitate online purchasing without the need to visit the store. The design of the user interface and user experience utilizes the user-centered design (UCD) method with the Figma design application. This method was chosen to design user interface and user experience that involve users based on their experiences. The results of testing using the Maze.design application show that the design of the user interface and user experience is user-friendly with an average usability score of 97.
Ensemble Learning Approach Reveals Significant Clinical Attributes from Real-World Breast Cancer Cases
Authors: Permana Angga Aditya , Romdendine Muhammad Fahrury
Published: April 2024

Breast cancer has become on of the leading causes of death in Indonesia. This study contributes to global efforts to combat breast cancer by improving patient outcome prediction accuracy. This study employed ensemble learning techniques such as Random Forest, XGBoost, and LightGBM. The results of the study demonstrates LightGBM's superior performance (accuracy=85%, ROC-AUC=81%, AUPR=85%). Notably, all three algorithms identify key clinical attributes: "Relapse Free Status (Months)", "Overall Survival (Months)", "Nottingham Prognostic Index", and "Lymph Nodes Examined Positive". LightGBM uniquely highlights "pam50_LumA" as significant, suggesting reduced fatality risk for Luminal A subtype patients, while others prioritize "Tumor Size". This research lays groundwork for intelligent systems to predict breast cancer outcomes, potentially transforming patient care and clinical practice.
How Positive Sentiment of Telemedicine Applications using Naïve Bayes and Support Vector Machine?
Authors: Andreas Andreas , Wella Wella
Published: April 2024

The telemedicine software lets users schedule appointments with physicians or hospitals, purchase medications online, read health-related news and publications, and have online consultations with doctors. Public opinion is necessary for this application to meet societal needs. The public's perception of contemporary health applications can be ascertained by looking to public opinion. Fine-grained sentiment analysis is used in public opinion taking to extract information from evaluations posted by the public and categorize it into positive and negative groups. Using RapidMiner as a supporting tool, sentiment analysis uses the Naïve Bayes Classification algorithm and Support Vector Machine to determine an accuracy value. After analyzing data from two different sources—Twitter and Playstore—it can be said that the Support Vector Machine algorithm performs 90.99% more accurately in predicting public opinion than the Naïve Bayes algorithm, which achieves 88.55% accuracy.
Analisis Pengendalian Kualitas dengan Menggunakan Metode Failure Mode and Effect Analysis dan Fault Tree Analysis pada Produk Songkok UD. XYZ
Authors: Farrizqi M. Danial , Andesta Deny
Published: April 2024

UD. XYZ merupakan perusahaan manufaktur produk songkok yang berkantor pusat di Kota Gresik. Perusahaan masih menghadapi beberapa kekurangan pada produknya. Oleh karena itu, perusahaan harus menjamin kestabilan kualitas produk dan mengurangi risiko kesalahan. Ketika dihadapkan pada situasi seperti ini, pengendalian kualitas sangat diperlukan untuk mengurangi tingkat kesalahan dan memastikan tidak melebihi batas yang telah ditentukan. Dalam penelitian ini digunakan metode FMEA dan FTA. Penerapan FMEA membantu mengidentifikasi risiko kesalahan selama proses pembuatan karpet. Dengan menggunakan FMEA, cacat yang menyebabkan kegagalan produk dapat diidentifikasi dan risiko kegagalan proses dinilai menggunakan nilai RPN. Hasil dengan RPN tertinggi akan dianalisis lebih detail menggunakan metode FTA untuk membangun pohon patahan, yang darinya dapat diidentifikasi akar permasalahannya. Berdasarkan hasil FTA, usulan perbaikan disusun dengan harapan dapat mengurangi tingkat kecacatan produk. Penelitian menemukan bahwa ada tiga jenis cacat. Jahitan tidak rapi (RPN=112), penyulaman tidak bagus (RPN=100), dan ukuran tidak sesuai (RPN= 90).
Usulan Perbaikan Tata Letak Fasilitas Mesin Preparasi Batubara dengan Metode From To Chart
Authors: Al Farizi Akhmad Muzaki Hilal , Jufriyanto Moh. , Rizqi Akhmad Wasiur
Published: April 2024

PT. XYZ merupakan produsen pupuk terlengkap di Indonesia. Salah satu aktivitas yang dilakukan dalam menunjang proses produksi pupuk yaitu analisis batu bara yang akan digunakan sebagai penggerak mesin produksi. Selama proses analisis ini diketahui sering kali terdapat gerakan bolak-balik karena penempatan alat-alat / fasilitas analisis yang tidak beraturan dan jauhnya jarak antar fasilitas. Penelitian ini dilakukan untuk mengurangi ongkos dan jarak material handling, salah satu metodologi yang cocok digunakan untuk menganalisis kondisi tersebut yaitu FTC, metodologi ini memiliki kelebihan untuk menentukan besarnya efektivitas material handling baik fordward maupun backward sera dapat memberikan layout usulan yang lebih efektif. Hasil penelitian diketahui bahwa terdapat efisiensi ongkos material handling sebesar Rp 103,071 perhari disebabkan karena menurunnya jarak antar fasilitas sebanyak 67,34 meter. Hal tersebut dapat mengefisiensi OMH maupun jarak antar fasilitas sebesar 38,48% serta persentase forward meningkat sebesar 8,16% menjadi 81,24%.
Effect of Preemptive Systemic Patient-controlled Analgesia in Evisceration
Authors: Jun Ji Ho , Lee Ga Hyun
Published: April 2024

Purpose: To investigate the effect of preemptive systemic analgesia using patient-controlled analgesia (PCA) on postoperative pain after evisceration.Methods: Of the patients who underwent evisceration under general anesthesia in our hospital, 55 who were able to evaluate pain using a numeral rating scale (NRS) were included. The patients were divided into two groups: group 1 used PCA after surgery, and group 2 used PCA preemptively before surgery. We compared the two groups in terms of the NRS pain scores on the day of surgery and 1, 2, and 3 days after surgery, and according to whether additional analgesics were used.Results: The 55 patients included 17 in group 1 and 38 in group 2. The NRS at 3, 5, and 7 hours on the day of surgery tended to be lower in group 2, but not significantly (p > 0.05). The NRS on days 1 and 2 after surgery was significantly lower in group 2 (p = 0.014 and p = 0.027, respectively), and the NRS on day 3 after surgery was also lower, although not significantly (p = 0.059). Significantly fewer cases required additional analgesics in group 2 compared to group 1 on the day of surgery and 1, 2, and 3 days after surgery (p = 0.001, p < 0.001, p < 0.001, and p = 0.008, respectively).Conclusions: Using preemptive systemic PCA in evisceration significantly reduced the postoperative pain, and PCA itself was an effective administration method due to the high rate of pain control without the need for additional analgesics.
Use of Big Data to Evaluate Adverse Ophthalmic Adverse Events after COVID-19 Vaccination
Authors: Youn Hyun Chul , Chey Ji Hyoung , Lee Chang Kyu
Published: April 2024

Purpose: This study explored the types and incidences of adverse ophthalmic adverse events after COVID-19 vaccination and their associations with such vaccination in patients who presented to the sole local, tertiary, general hospital in region Ulsan of South Korea complaining of ophthalmic discomfort after COVID-19 vaccination.Methods: This cross-sectional study was conducted at Ulsan University Hospital, which is the only tertiary general hospital in Ulsan city. All participants visited the hospital from March 2021 to August 2022 complaining of ophthalmic discomfort after COVID-19 vaccination. Clinical variables were collected from both our clinical data warehouse and the electronic medical records of the hospital.Results: To date, 2,766,569 COVID-19 vaccine doses have been administered in Ulsan city. A total of 97 cases of vaccination-related adverse ophthalmic events have been confirmed. In 21 of these cases, irreversible sequelae persisted after the side-effects. Most symptoms developed within 1 week after vaccination (mean 5.06 ± 6.86 days). The most common symptom was visual disturbance (67 cases), followed by ocular pain (19 cases) and double vision (16 cases). The most frequent diagnoses associated with irreversible sequelae were neurological diseases (7 cases), retinal diseases (5 cases), and glaucoma (5 cases). The frequencies of side effects were highest for those of BNT162b2 status (34 cases), followed by those of ChAdOx1 (30), mRNA-1273 (20), and Ad26.COV2.S (4).Conclusions: In contrast to other vaccinations, COVID-19 vaccination was viewed as urgent; a few known ophthalmic side effects developed after vaccination. Although such adverse events are rare, affected patients must be closely monitored; the sequelae may be irreversible.
Comparison between Focal Laser Photocoagulation and Intravitreal Bevacizumab Injection for Treating Chronic Central Serous Chorioretinopathy
Authors: Yoon Young Bin , Choi Woo Seok , Lee Kyoo Won , Park Dong-Geun
Published: April 2024

Purpose: We compared the efficacy of focal laser photocoagulation and intravitreal bevacizumab injection in the treatment of chronic central serous chorioretinopathy.Methods: We conducted a retrospective analysis involving 46 eyes of 46 patients with chronic central serous chorioretinopathy who received focal laser photocoagulation (22 eyes) or intravitreal bevacizumab injection (24 eyes). Changes in best-corrected visual acuity (BVCA), central macular thickness, and rates of complete subretinal fluid (SRF) resolution and recurrence were compared over a 6-month period.Results: Although the focal laser photocoagulation and intravitreal bevacizumab injection groups demonstrated a significant reduction in central macular thickness at 6 months (p < 0.001), no statistically significant differences were observed between these groups at the end of the follow-up period. Notably, a gradual improvement in BVCA was observed in both groups following initial treatment, with significant improvement seen at 6 months (p = 0.049 and p = 0.048 for the laser and injection groups, respectively). However, no statistically significant difference in BVCA improvement was observed between the groups. Complete SRF resolution was achieved in 22 eyes in the laser group and 23 eyes in the injection group. Although recurrence of SRF was observed in 9 and 13 eyes in the laser and injection groups, respectively, there was no statistically significant difference between the groups (p = 0.229).Conclusions: Focal laser photocoagulation and intravitreal bevacizumab injection significantly improved anatomical and visual acuity outcomes in patients with chronic central serous chorioretinopathy. Although focal laser photocoagulation was associated with more rapid visual recovery and a lower recurrence rate compared to intravitreal bevacizumab injection, further studies are needed to evaluate its potential complications.
A Case of Excessive Axial Length Elongation Following Retinal Detachment Vitrectomy
Authors: Park Hyung Seok , Shin Jeong Wook , Lee Donghun , Lee Geun Woo
Published: April 2024

Purpose: To report a case of excessive axial length elongation following vitrectomy for rhegmatogenous retinal detachment.Case summary: A 21-year-old male patient presented to our hospital with visual impairment. The patient had previously undergone computed tomography in our emergency room for a facial contusion 3 years prior to his current visit. Axial lengths of 27.23 mm in the right eye and 27.62 mm in the left eye were recorded at that time. The patient had no previous ocular history. Fundus examination revealed extensive retinal detachment with macular involvement and hypotony retinopathy in the left eye. Retinal detachment surgery was subsequently performed on the left eye. Following the surgery, intraocular pressure in the left eye increased and intraocular pressure-lowering medications were administered. At 3 months postoperatively, the patient developed additional retinal detachment in the right eye, prompting retinal detachment surgery. Unlike the contralateral eye, the intraocular pressure remained well-controlled postoperatively. Axial length measurement was performed due to the complaint of left eye protrusion. The axial lengths were 27.76 mm and 31.41 mm in the right and left eyes, respectively. There was a significant increase in the axial length of the left eye but not in that of the right eye compared to 3 years prior.Conclusions: Gas tamponade, preoperative ocular hypotension, and postoperative ocular hypertension can cause excessive axial length elongation in cases of rhegmatogenous retinal detachment in young patients with high myopia.
Bilateral Extensive Serous Retinal Detachment in a Patient with Multiple Myeloma
Authors: Shin Jeong Hwa , Song Ik-Chan , Jo Deog Yeon , Nam Ki Yup
Published: April 2024

Purpose: To describe a case of bilateral serous retinal detachment in a patient with multiple myeloma.Case summary: A 75-year-old woman presented with sudden-onset of reduced visual acuity in both eyes which had begun 2 days prior. Initial ophthalmological assessment revealed that visual acuities were 0.03 in the right eye and 0.05 in the left eye. Optical coherence tomography indicated pronounced macular elevation and extensive subretinal fluid accumulation in the posterior pole of both eyes. Fluorescein angiography did not detect any significant vascular leakage. Blood tests showed an albumin level of 2.1 g/dL, and plasma protein electrophoresis revealed an M protein level of 0.19 g/dL. Multiple myeloma-related hypoalbuminemia and paraprotein were suspected. The patient's retinal statuses were closely monitored and compared with blood test outcomes. Over 2 months, there was significant improvement, characterized by decreasing macular elevation and reduction of subretinal fluid. This progress was sustained thereafter. Plasma protein electrophoresis showed a gradual decline in paraproteins which coincided with the amelioration of serous retinal detachment.Conclusions: We encountered a case of acute and extensive serous retinal detachment in both eyes of a patient with multiple myeloma. When fluorescein angiography does not definitively show vascular leakage, light chain deposition disease-related serous retinal detachment should be considered. In such instances, it is important to address and monitor the underlying multiple myeloma.
Unilateral Internuclear Ophthalmoplegia in a 14-year-old Female
Authors: Oh Il Joong , Oh Jun Ho , Chun Bo Young
Published: April 2024

Purpose: Internuclear ophthalmoplegia (INO) is an eye movement disorder caused by a lesion of the medial longitudinal fasciculus. It typically manifests bilaterally and is commonly caused by multiple sclerosis. We report a case of pediatric unilateral INO, which is rare in the pediatric population.Case summary: A 14-year-old female, with a history of traumatic head injury 9 days previously, presented with diplopia, nausea and vomiting for the past 5 days. Her ophthalmic examination revealed severely impaired adduction of the right eye and abduction nystagmus in the left eye. Orbital computed tomography showed no evidence of orbital wall fracture or muscle impingement. However, an magnetic resonance imaging of her brain demonstrated an infarct in the right paramedian midbrain, leading to a diagnosis of unilateral INO. Diplopia and impaired adduction of the right eye resolved completely 7 weeks after the trauma.Conclusions: Demyelinating diseases, such as multiple sclerosis, account for most of the pediatric INO cases. Although most of these cases are bilateral, this reports highlights a pediatric case of unilateral INO following head injury, which is an uncommon occurrence in this age group.
An Examination of The Link Between Business Ethics and Corporate Governance Principles of Smes in Kwazulu Natal, South Africa: Application of Shareholder Theory
Authors: Mahohoma Tinaye , Musvoto Godfrey
Published: April 2024

This study examines the relationship between business ethics and corporate governance principles in small and medium-sized enterprises (SMEs) in the KwaZulu Natal region of South Africa. It aims to understand how ethical behavior and practices within SMEs can promote good corporate governance, using the framework of shareholder theory. The study employs a quantitative research design, collecting data from a sample of 217 active SMEs through a close-ended questionnaire. The data is analysed using statistical methods, including chi-square tests, Spearman ranked correlation coefficient, and regression analysis. The results indicate a significant positive correlation between business ethics and corporate governance in SMEs, emphasizing the importance of ethical conduct in maximising shareholder value while considering broader ethical implications. Based on the findings, several recommendations are provided. SMEs should prioritise the development of robust ethical frameworks, promote a culture of integrity and accountability, and invest in ethical leadership development. Collaboration and knowledge-sharing among SMEs can facilitate the adoption of ethical practices. Policymakers and regulatory bodies should recognise the significance of business ethics and corporate governance in SMEs and provide support and incentives for their implementation.
Atributos da atenção primária na saúde da criança: A ótica dos cuidadores, Porto Velho-Rondônia
Authors: Oliveira Tatiana Michelle Catão de , Freitas Jeanne Lúcia Gadelha , Souza Maria Helena do Nascimento , Moura Cleson Oliveira de , Cavalcante Daniela Ferreira Borba , Santos Adria da Silva , Castro Lorena Rios
Published: April 2024

Objetivo: avaliar sob a ótica dos cuidadores, a atenção à saúde prestada à criança na primeira infância em Porto Velho-RO, considerando os atributos essenciais e derivados da Atenção Primária à Saúde. Método: estudo transversal, quantitativo, realizado com 190 cuidadores de crianças de zero a cinco anos de idade, acompanhadas em uma unidade básica de saúde de Porto Velho-RO, em 2021. Foi utilizado o Primary Care Assessment Tool (PCATool - Brasil 2020) versão infantil, com definição de alta (≥ 6,6) ou baixa (< 6,6) orientação para APS. Resultados: na avaliação dos cuidadores, houve uma alta orientação do serviço para a APS, com escore geral (6,80) e escore essencial (7,27). Conclusão: o estudo revelou atributos com escores satisfatórios, o que reflete pontos positivos do serviço de saúde avaliado. Entretanto, considera-se fundamental repensar e intervir sobre fatores que se mostraram insatisfatórios para a qualidade do serviço da Atenção Primária à Saúde da criança.
Regeneração óssea guiada como forma de tratamento para periimplantite: Relato de caso
Authors: Tardelli Juliana Peregrino de Brito , Melo Ana Tatiana Gonzalez de , Franceschini Neto Francisco , Silva Ennyo Sobral Crispim da , Farias Naiara de Oliveira
Published: April 2024

Objetivo: O objetivo do presente estudo é relatar um caso clínico de periimplantite em que a falta de higiene oral representou um fator decisivo para a perda de um dos implantes instalados anteriormente. Método: Trata-se de um estudo de caso, numa abordagem qualitativa, por ser o objeto de estudo o resultado e elemento em investigação. Resultados e Discussão: Após a instalação de implantes, o paciente apresentou uma infecção com secreção purulenta na região, tendo o paciente procurado o serviço queixando-se de dor na região. Foi realizado o acompanhamento e, posteriormente, sessões de raspagem e desinfecção com clorexidina a 2%. Após 3 meses, como não se observou melhoras no padrão de higienização por parte do paciente, na tentativa de estimular a formação óssea na região da periimplantite, foi realizada uma ROG(Regeneração Óssea Guiada), onde são utilizados biomateriais e osso bovino para guiar o crescimento do osso na região afetada. Conclusão: A descontaminação incompleta da superfície parece ser o maior obstáculo para neoformação óssea na superfície previamente exposta do implante. Pelo que foi observado, pode-se concluir que o controle do biofilme mantém a saúde da interface do tecido mole–implante, existindo uma relação entre a presença de biofilme com a inflamação dos tecidos ao redor dos implantes.
Influencia de las enfermedades sistémicas en la reparación postendodóntica
Authors: Astudillo Kenia Karen Kun , Azanza Santacruz Carolina Michelle , Freire Narvaez Johanna Estefanía
Published: April 2024

Las enfermedades sistémicas son afecciones que impactan en varios sistemas de órganos, lo que afecta el sistema inmunológico de quienes las padecen. A nivel oral, estas enfermedades manifiestan signos y síntomas los cuales, combinados con la deficiencia en los mecanismos de defensa de los pacientes y las alteraciones en los procesos de curación, influyen directamente en la eficacia de los tratamientos dirigidos a abordar patologías endodónticas. El propósito de esta investigación consiste en examinar la literatura seleccionada que aborda la influencia de las enfermedades sistémicas (diabetes, VIH, enfermedades cardiovasculares, autoinmunitarias, enfermedades inflamatorias intestinales y el tabaquismo) en la reparación posendodóntica. Materiales y métodos: La obtención de información se llevó a cabo a través de búsquedas en bases de datos como Pubmed, Google académico, Scopus, EBSCO host, Science Direct, Elsevier y ResearchGate, seleccionando investigaciones de acuerdo a criterios de inclusión y exclusión. Resultados: Las enfermedades sistémicas como la diabetes, enfermedades cardiovasculares, infección por VIH, enfermedad inflamatoria intestinal y el hábito de fumar pueden interferir en el proceso de reparación de los tejidos periapicales después de un tratamiento endodóntico.  Conclusiones: Se sugiere el impacto de las enfermedades sistémicas en el proceso de reparación posterior al tratamiento endodóntico. Sin embargo, se requiere más estudios longitudinales para evaluar el efecto de las enfermedades sistémicas en la curación periapical.  Además, se resalta la importancia del conocimiento sobre la salud sistémica de los pacientes ya que puede alterar el resultado del tratamiento de infecciones endodónticas.
Análise de relatos de dependentes químicos em recuperação a partir da perspectiva da inteligência espiritual
Authors: Vieira Brenda , Dutra Crys Michelly de Oliveira , Carvalho Millena Gonçalves de , Sales Antonio
Published: April 2024

Este artigo é resultado de um projeto de Iniciação Científica financiado pelo Programa Institucional de Bolsas de Iniciação Cientifica e desenvolvido por acadêmico(a)s de medicina com adictos em uma Casa de Recuperação. O trabalho consistiu na escrita de uma carta pelos adictos a uma pessoa querida relatando a sua experiência de vida e como está vivenciando o processo de recuperação. É uma pesquisa qualitativa, descritiva, e está se dando em etapas. Das 44 cartas escritas, cinco foram escolhidas, pela extensão do seu conteúdo, para esta análise e as demais ficaram para outra etapa do processo. A teoria de sustentação para o estudo foi a Inteligência Espiritual conforme as vertentes de Torralba, Zohar e Marshall. Ressalta-se que a inteligência espiritual não se resume à religião, mas, sobretudo à busca pelo sentido da vida e a capacidade individual se situar no mundo. Assim, o estudo teve como objetivo analisar a contribuição da inteligência espiritual no processo de recuperação química. Os resultados apontam que a Casa de Recuperação tem um relevante papel no desenvolvimento da Inteligência Espiritual, que por si, influencia positivamente no processo de recuperação.
Eficácia da utilização de lentes de óculos com tecnologia Defocus Incorporated Multiple Segments para correção e controle da progressão de miopia em crianças e adolescentes
Authors: Barbosa Giovana Dalla Rosa , Castro Alanderson Passos Fernandes , Melo Ana Clara Carneiro Fernandes de , França Giovanna Gomes , Santos Gabriella Basilio Rodrigues dos , Fiuza Lenara Lima
Published: April 2024

A prevalência da miopia está aumentando globalmente, sendo que a presença do quadro de alta miopia eleva os riscos do desenvolvimento de deficiências visuais permanentes que poderiam ser evitadas. O acesso à correção refrativa apropriada e à métodos de prevenção e controle da progressão da miopia são medidas eficazes para evitar tal comprometimento da visão. O objetivo do presente artigo é apresentar os resultados sobre a eficácia da utilização de lentes de óculos com tecnologia Defocus Incorporated Multiple Segments (DIMS) para correção e controle da progressão da miopia em crianças e adolescentes. Realizou-se uma revisão integrativa da literatura, seguindo a linha orientadora PRISMA para extração dos artigos científicos. Foram incluídos ensaios clínicos, publicados entre 2018 e março de 2024 nas bases de dados PubMed e Biblioteca Virtual em Saúde, que compraram os efeitos das lentes DIMS em relação às lentes de visão simples (SV) para controle da progressão da miopia, com participantes de idades entre 6 e 18 anos e em um período de seguimento mínimo de 12 meses. Em suma, incluiu-se 5 estudos que se enquadram nos critérios de elegibilidade e no escopo da pesquisa. Os parâmetros utilizados para análise comparativa foram a variação do equivalente esférico de refração e do comprimento axial durante a utilização do tratamento atribuído. A partir desses, verificou-se que as lentes SV não demonstraram efeito retardador da miopia, enquanto as lentes DIMS foram eficazes para tal função, revelando, assim, a eficácia do desfoque miópico periférico na retina para controlar a progressão da miopia.
Cuidado multiprofissional à pessoa com transtorno mental na atenção primária à saúde: Relato de experiência
Authors: Silva Filho João Batista , Araujo Pedro Henrique Magalhães de , Sousa Francisco Antônio de , Sousa Luana Silva , Aguiar Daniele Tomaz , Fontenele Thaisa Quixadá , Trindade Jéssica Lima
Published: April 2024

O cuidado multiprofissional destaca-se como uma estratégia que serve para fortalecer as ações de saúde mental, na Atenção Primária à Saúde (APS). Objetivou-se descrever a vivência prática de uma equipe de saúde relacionada à pessoa com transtorno mental, acompanhada pela APS, através de um estudo de caso. Tratou-se de um relato de experiência, dividido em: escolha e descrição do caso; aplicação da Estratificação de Risco em Saúde Mental; apresentação das ações da equipe multiprofissional. O médico atuou no tratamento medicamento; o psicólogo, na psicoterapia; a assistente social, na mediação de conflitos e na busca por benefício social; a odontóloga, no tratamento dentário; o enfermeiro, na organização dos serviços e orientações biopsicossocioculturais. Sugere-se o desenvolvimento de mais estudos que abordem a referida temática, a fim de disponibilizar resultados de vivências, que servirão para o surgimento de outras ações de saúde mental, na APS.
Conhecimento, uso e manejo de plantas alimentícias entre o Povo Puyanawa, Alto Juruá, estado do Acre, Brasil
Authors: Fowler Luana , Noda Hiroshi , Martins Ayrton Luiz Urizzi , Haverroth Moacir , Kinupp Valdely Ferreira
Published: April 2024

Este estudo se propôs a conhecer o saber dos Puyanawa, povo indígena habitante do Vale do Alto Rio Juruá, Acre, quanto à agrobiodiversidade das plantas de uso alimentício, suas formas de manejo, conservação e uso, no intuito de contribuir para a expressão e fortalecimento cultural, evidenciando a importância do território para o bem-viver dos povos da floresta. No estudo qualitativo, realizado por meio de entrevistas semi-estruturadas, turnês-guiadas e recordatório alimentar, foram entrevistadas 33 famílias, entre as quais 81 indivíduos. Foram encontradas 95 espécies de plantas alimentícias nos agroecossistemas utilizados pelos Puyanawa, o que representa uma diversidade interessante de fontes de vitaminas, proteínas e minerais. A produção de espécies alimentícias apresenta uma oferta regular ao longo do ano, sendo a sazonalidade, um dos fatores que asseguram essa diversificação. As plantas encontradas nos agroecossistemas contribuem de maneira significativa na alimentação das famílias e os vegetais que compõem a base da alimentação são, majoritariamente, de procedência interna. Por outro lado, podemos notar a forte tendência de alimentos globalizados ganharem espaço na alimentação diária, podendo vir a comprometer a saúde e ameaçar a segurança e soberania alimentar e nutricional dos Puyanawa. Acreditamos que a atitude dos povos indígenas em garantirem a resiliência e conservação de suas práticas agrícolas tem muito a contribuir com toda a humanidade. Ressaltamos o valor inestimável que possuem os agroecossistemas e o conhecimento tradicional associado às plantas alimentícias para a autonomia e o bem-viver dos povos da floresta.
Anemia de Fanconi: Métodos diagnósticos e a aplicabilidade da genética laboratorial
Authors: Dantas Dary Medeiros , Pereira Hannaly Wana Bezerra
Published: April 2024

A Anemia de Fanconi (AF) é uma doença hereditária autossômica recessiva ou ligada ao cromossomo X que se manifesta nos primeiros anos de vida, sendo responsável por anomalias congênitas e falência medular progressiva tendo como principal característica a anemia aplástica (AA). Este artigo de revisão teve como objetivo identificar as metodologias diagnósticas utilizadas na detecção da AF envolvendo a aplicabilidade genética, clínica e laboratoriais. Para esse estudo foram consultadas as bases de dados científicas eletrônicas como, o Portal States National Library of Medicine National Institutes of Health (Medline/PubMed), Web Of Science, e Scientific Electronic Library Online (SciELO). Foram encontrados um total de 1563 artigos científicos nos idiomas inglês, espanhol e português, em que 6 deles foram incluídos para análise. Evidenciou-se a existência de dois testes de fragilidade cromossômica, um método em biologia molecular e um método de sequenciamento de DNA, e que o grau de especificidade encontrado nos métodos Western blot e mitomicina C (MMC) complementam o diagnóstico da AF. O diepoxibutano (DEB) se diferencia em relação ao Western blot e o MMC por ser mais específico em quebras cromossômicas, sendo o sequenciamento de nova geração (NGS) o mais específico e mais informativo por conduzir a uma abordagem personalizada devido a facilidade de acesso as variações somáticas em tumores e alterações na expressão gênica. Diante disso, conclui-se que esses métodos proporcionam maior especificidade diagnóstica ao identificarem a associação gênica da AF e o mosaicismo somático, entendendo os níveis de gravidade trazendo maior agilidade na tomada de medidas terapêuticas.
A atuação do enfermeiro como gestor operacional da atenção primária unidade de saúde no Complexo da Maré, no Rio de Janeiro (RJ)
Authors: Albuquerque Robson Jancer do Nascimento , Araújo Patrícia Gonzalez Machado , Santos Valeska Kely dos
Published: April 2024

Este estudo exploratório e aplicado, com abordagem qualitativa teve como objetivo identificar as principais dificuldades/desafios enfrentados pelo profissional de enfermagem na gestão operacional da APS no Complexo da Maré, Rio de Janeiro (RJ). Através de entrevistas com enfermeiros de três das sete unidades de saúde da região, identificou-se a necessidade de aprimoramento na comunicação, estabelecimento de metas comuns e capacitação profissional. A violência na região também se destacou como um desafio crítico, exigindo políticas públicas e estratégias específicas para garantir segurança e acesso à saúde. Os resultados evidenciam a necessidade de aprimoramento na gestão da Atenção Primária à Saúde (APS), enfatizando comunicação eficaz, metas comuns, reuniões regulares de equipe e capacitação de profissionais. Ressalta-se também a importância do investimento em infraestrutura, identificado como um aspecto positivos, e inovação para superar desafios na qualidade dos serviços. Reconhece-se que os resultados obtidos são específicos para o Complexo da Maré, podendo não ser totalmente aplicáveis a outras regiões.
A STUDY ON JOB ANALYSIS IN COMMUNITY PHARMACIES: CASE OF ANKARA
Authors: Zanbak Canan Mine , Uzun Mehmet Barlas , Özçelikay Gülbin
Published: April 2024

Objective: Job analysis is a method in which the duties and responsibilities in an organization are examined and researched systematically. The aim of this study is to determine both the workload of the pharmacist including the consultation to the patients and administrative works in community pharmacies, and the time allocated to these responsibilities. We are presenting advices which increase the productivity of the management.
Material and Method: This study is descriptive-survey research. In this research, the survey method was used as a data collection tool. A questionnaire was prepared for the study, which was created by conducting interviews identifying the tasks that the pharmacists do in their routine. The survey was applied to a small number of pharmacists. The final version was sent by e-mail to pharmacists located in Ankara.
Result and Discussion: It was determined that pharmacists spend most of their time in the pharmacy on patient counseling. Pharmacy staff assist the pharmacist with counseling, but mostly with administrative work. This study is important for the students who plan to be community pharmacists to be able to manage their pharmacies efficiently. It shows that the work awaits them in a community pharmacy and the time to do the work in the pharmacy on average basis.
Experience in creating a three-dimensional model of a cultural building based on combined geodetic survey data
Authors:   Department of geodesy and cartography, National University of Water and Environmental Engineering, YANCHUK R. , YANCHUK O. ,   Department of geodesy and cartography, National University of Water and Environmental Engineering, TROHIMETS S. ,   Department of geodesy and cartography, National University of Water and Environmental Engineering, ANDROSYUK M. ,   Department of geodesy and cartography, National University of Water and Environmental Engineering, SAVCHYN I. ,   Lviv Polytechnic National University, LOZYNSKYY V. ,   Lviv Polytechnic National University
Published: April 2024

The purpose of the research is to test algorithms for creating a three-dimensional model of an object based on point clouds obtained from combined geodetic surveys (UAV survey and ground laser scanning). The methodology is based on the collection of a cloud of points by ground laser scanning and the acquisition of a cloud of points on the same object by the photogrammetric method based on data taken from a UAV. The formation of the resulting three-dimensional model is performed according to the most reliable data from the point of view of geometric accuracy. The results. Each of the point cloud acquisition methods (UAV or laser scanning) has its advantages for certain parts of the building. Thus, the modeling of the upper part of the building, sloping and complex roofs is best performed based on the data taken from the UAV, vertical walls and the elements placed in them (windows, decoration elements, etc.) – based on point clouds obtained from laser scanning. Scientific novelty and practical significance. The method of processing point clouds obtained from various sources on the basis of free software was tested. The approach discussed in the article has significant potential for use in many branches of the national economy. The performer can combine measurement data from various sources on the basis of free software and prepare them for further export to the necessary software for creating a model.