bluuebunny/crossref_metadata_2025 huggingface dataset:
circ_000166/miR-296 Aggravates the Process of Diabetic Renal Fibrosis by Regulating the SGLT2 Signaling Pathway in Renal Tubular Epithelial Cells
Authors: Chen Sheng
Published: May 2022

Diabetic renal fibrosis is a common cause of end-stage renal disease, and the circRNA-miRNA-mRNA network may play an important role in the progression of diabetic nephropathy- (DN-) induced renal fibrosis. In this study, the role of circ_000166/miR-296/SGLT2 in the process of DN-related renal fibrosis was studied by constructing an animal model of DN renal fibrosis via lentiviral transfection, plasmid transfection, and dual-luciferase reporting techniques. Compared with that of normal controls, the expression of circ_000166 in the kidney tissues of DN renal fibrosis mice substantially increased. Silencing circ_000166 could minimize kidney damage and decrease urine protein levels, thereby inhibiting the progression of renal fibrosis. Moreover, circ_000166 could act as the ceRNA of miR-296 and competitively bind to miR-296, leading to an increase in the expression of the SGLT2 gene regulated by miR-296. Through mutual verification via in vivo and in vitro experiments, miR-296 was overexpressed and SGLT2 was silenced. Results showed that DN renal fibrosis and cell apoptosis were considerably reduced. We postulate that circ_000166/miR-296/SGLT2 may become a new target in the progression of DN renal fibrosis, and the regulation of this pathway may be a promising strategy for clinical treatment of DN renal fibrosis.
Sensor and Attitude Analysis of Track and Field Training Action Recognition Based on Artificial Intelligence
Authors: Liu Chaonan , Chang Zenghui
Published: May 2022

In order to provide effective information support to athletics training and to increase the effectiveness of athletics training, in-depth analysis of motion recognition sensors and attitudes based on artificial intelligence was conducted. First of all, the basic conditions of type analysis, cognitive technology, and the current situation were studied, and the basic theory related to it was studied, and on this basis, a human position analysis and recognition system based on artificial intelligence movement training sensors was developed. We studied the technology in depth. Experiments have shown that the approach data collected by the system’s inertia node is transmitted wirelessly to the computer-side software to restore the trend and identify each trend and parameter with high accuracy. During the 30-minute test, the static error was within 1° and the dynamic error was within 5°, which is acceptable and adheres well to dynamic conditions. The system can overcome the limitations of traditional wired or optical methods and be widely used in sports training, human-computer interaction monitoring, rehabilitation medicine, games, film, and television production.
Review of Particle Breakage Measurement Methods for Calcareous Sand
Authors: Xu Liang-Jie , Wang Ren , Xu Dong-Sheng , Wang Xin-Zhi , Meng Qing-Shan , Zhu Chang-Qi
Published: May 2022

In order to better understand the particle breakage mechanics and characterization methods of calcareous sand, the particle breakage characteristics of calcareous sand in one‐dimensional compression tests, isotropic compression tests, triaxial shear tests, and ring shear tests are reviewed and analyzed. The results show that the mechanism of shear crushing is essentially different from compression crushing. Compared with one‐dimensional compression, it is easier to break calcareous sand under triaxial shear. In the shearing process, the particle breakage of calcareous sand will not continue indefinitely. The gradation tends to be stable and controlled by confining pressure and shear strain. The characteristic particle size measurement method for particle breakage is simple and has limitations. The description method using the particle size distribution curve is more comprehensive, but it is impossible to compare the crushing degree of particle with different particle sizes, and a suitable measurement method needs to be proposed.
Intercellular Communication-Related Molecular Subtypes and a Gene Signature Identified by the Single-Cell RNA Sequencing Combined with a Transcriptomic Analysis
Authors: Guan Pin , Cai Wentao , Wu Ke , Jiang Fan , Wu Jinchan , Zhai Xin , Zeng Min
Published: May 2022

Background. The tumor microenvironment (TME) of lung adenocarcinoma (LUAD) comprise various cell types that communicate with each other through ligand-receptor interactions. This study focused on the identification of cell types in LUAD by single-cell RNA sequencing (scRNA-seq) data and screening of intercellular communication-related genes. Methods. The Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo) provided the RNA-seq data of LUAD patients in the GSE149655, GSE31210, and GSE72094 datasets. Quality control of the scRNA-seq data in GSE149655 was performed by the Seurat package (http://seurat.r-forge.r-project.org) for identifying highly variable genes for principal component analysis (PCA) and cell clustering. The CellPhoneDB (http://www.cellphonedb.org) was used for filtering intercellular communication-related ligand-receptor pairs. According to ligand and receptor expressions, LUAD samples were clustered using ConsensusClusterPlus (https://www.bioconductor.org/packages/release/bioc/html/ConsensusClusterPlus). Additionally, the identification of prognosis-related ligand and receptor genes was conducted along with the development of a risk prediction model by the least absolute shrinkage and selection operator (LASSO) Cox regression analysis. Results. This study identified twelve cell types in 8170 cells of LUAD tissues along with 219 ligand and receptor genes. LUAD was classified into three different molecular subtypes, among which cluster 3 (C3) had the longest overall survival (OS) time and cluster (C1) had the shortest OS time. In comparison with the other two molecular subtypes, it was observed that C1 had a higher rate of somatic mutations and lower levels of infiltrating immune cells and immune scores. Ten genes were screened from the total ligand and receptor genes to construct a risk model, which showed a strong prediction power in the prognosis of patients with LUAD. Conclusion. The results of this study revealed cell types specific to LUAD, which were classified into different molecular subtypes according to intercellular communication-related genes. A novel prognostic risk model was developed in this study, providing new insights into prognostic assessment models for LUAD.
The Value of Four Anthropometric Indicators for Identifying Left Ventricular Hypertrophy in Chinese Hypertensive Patients
Authors: Cheng Bokai , Lu Nan , Song Ge , Qiu Jiaojiao , Dong Jing , Cai Shuang , Su Yongkang , Sun Jin , Zhang Anhang , Bao Qiligeer , Li Man , Ma Shouyuan , Zhang Yan , Zhu Ping , Wang Shuxia
Published: May 2022

Left ventricular hypertrophy (LVH) has been classified separately as an independent risk factor for hypertension. However, comparisons between different body size indices and left ventricular hypertrophy (LVH) in hypertensive populations have not been reported yet. In this study, we enrolled 4,639 hypertensive patients from rural China. Anthropometric indices and cardiovascular disease risk factor variables were measured and analyzed using Spearman’s correlation, logistic regression, and receiver operating characteristic (ROC) curve analyses. Patients in the highest quartile of body size indices were more likely to have left ventricular hypertrophy than those in the lowest quartile; these indices were BMI (adjusted OR: 3.55, 95% CI: 2.90; 4.35), WC (adjusted OR: 2.23, 95% CI: 1.84; 2.70), WHR (adjusted OR: 1.44, 95% CI: 1.18; 1.75), and WHtR (adjusted OR: 3.23, 95% CI: 2.62; 3.99). The areas under the ROC curves of BMI (AUC: 0.628, 95% CI: 0.612; 0.644), WHtR (AUC: 0.628, 95% CI: 0.560; 0.593), WHR (AUC: 0.530, 95% CI: 0.513; 0.547), and WC (AUC: 0.576, 95% CI: 0.513; 0.547) were all above 0.5, which indicated that the four anthropometric indicators may be associated with LVH. The four anthropometric indicators of obesity were identified as risk factors for LVH. Weight control might help reduce the risk of left ventricular hypertrophy.
Research on the Influencing Factors of Technology Path Transformation of Latecomer Enterprises
Authors: Chen Yunqi , Wang Huimin
Published: May 2022

This paper adopts the fuzzy set qualitative comparative analysis method to carry out an empirical analysis on Chinese latecomer enterprises and examines the key factors and realization paths that affect the technology path transformation of latecomer enterprises. This paper finds that there are configuration characteristics among the influencing factors of the technological path transformation of latecomer enterprises. The paper reveals the causal complexity mechanism of multiple factors that jointly affect technology path transformation. The key factors that affect the technological path transformation of latecomer enterprises include organizational vigilance, strategic transformation capability, network connections breadth, resource governance depth, dynamics of the technological environment, and the scale of social demand for technology. The above factors not only emphasize that latecomer enterprises should focus on new technologies rather than the market but also reveal that strategic transformation capability and resource governance depth are the keys for enterprises to achieve technology path transformation. In addition, it is pointed out that latecomer enterprises should pay attention to the “window of opportunity” brought about by the scale of social demand for technology. The transition from technology path dependence to technology path transformation of latecomer enterprises is a process in which the key factor becomes stronger.
Modeling Energy Gap of Doped Tin (II) Sulfide Metal Semiconductor Nanocatalyst Using Genetic Algorithm‐Based Support Vector Regression
Authors: Okoye Peter Chibuike , Azi Samuel Ogochukwu , Owolabi Taoreed O. , Adeyemi Oke Wasiu , Souiyah Miloud , Latif Mouftahou B. , Olusayo Olubosede
Published: May 2022

Tin (II) sulfide (SnS) is a metal chalcogenide semiconducting material with fascinating and admirable physical features for practical applications in solid‐state batteries, photodetectors, gas sensors, optoelectronic devices, emission transistors, and photocatalysis among others. The energy gap of SnS semiconductor nanomaterial that facilitates its usefulness in many applications can be adjusted through dopant incorporation which results in crystal lattice distortion at various crystallite sizes of the semiconductor. This work employs lattice parameter descriptors to develop a hybrid genetic algorithm (GA) and support vector regression algorithm (SVR) intelligent model for determining the energy gap of doped SnS semiconductors. The predictive strength of the developed GA‐SVR model is compared with the stepwise regression algorithm‐ (STRA‐) based model using different performance evaluation parameters. The developed GA‐SVR model performs better than STRA model based on root mean square error, mean absolute error, and correlation coefficient with performance improvement of 70.68%, 67.63%, and 20.98%, respectively, using the testing set of data. Influence of different dopants and experimental conditions on energy gap of SnS semiconductor were investigated using the developed model, while the obtained values for the energy gaps agree with the measured values. The developed models demonstrate high degree of potentials in terms of accuracy, precision, and ease of implementation that fosters their real‐life applicability in estimating the energy gap of doped SnS semiconductor with experimental stress circumvention.
Review and Evaluation of Power Devices and Semiconductor Materials Based on Si, SiC, and Ga‐N
Authors: Ramkumar M. Siva , Priya R. , Rajakumari R. Felshiya , Valsalan Prajoona , Chakravarthi M. Kalyan , Latha G. Charlyn Pushpa , Mathupriya S. , Rajan Kavitha
Published: May 2022

There is no reservation that semiconductor equipment distorted the world despite the fact of doing the practical experiments and also in research field. Researchers will communicate the process of semiconductor statistics with nearby pupils. In this work, diverse brand of semiconductor equipment was thrashed out with elementary properties and their distinctiveness. One type of semiconductor is differentiated based on energy band gap with an added type of semiconductor equipment. Semiconductor resources are the edifice block for the electrical and electronics component. This work makes an available apt generic argument of materials with the latest discussion and its impact of temperature on different materials, and it also reveals dissimilar parameters such as modern density, porch voltage value, transmission rate, and drain resistance value. Exceptional applications were discussed for divergent semiconductor materials.
Application of Nanotubes Combined with Ethnic Sports Rehabilitation Therapy in the Treatment of Patients with Knee Arthritis
Authors: Li Juan
Published: May 2022

National sports are traditional sports of ethnic minorities and sports with strong national characteristics. Sports performances generally include weightlifting, boxing or martial arts, gymnastics, skating, high jump, sprint, and hurdles. Such as knee joints that are particularly vulnerable to injury. Therefore, ordinary ethnic sports athletes are particularly vulnerable to injury. Ethnic sports rehabilitation therapy uses some exercises to enable patients to obtain full or partial exercise functions. Training methods for sensory function recovery were used. Ethnic sports rehabilitation therapy is a common rehabilitation therapy for ethnic sports athletes to resume sports training, such as table tennis, tennis, cycling, fishing, climbing, skating, weightlifting, and wrestling. However, with economic development and social progress, the treatment of knee arthritis is closely integrated with nanotubes combined with national sports rehabilitation therapy, and it has been increasingly used in competitive sports and national fitness. From 2003 to 2020, the medical research literature on nanotechnology increased from 20 to more than 20,000. This article presents a way for treating knee arthritis sufferers by combining nanotubes with ethnic sports rehabilitation therapy and discusses the clinical therapeutic effect of nanotubes combined with ethnic sports rehabilitation therapy in the treatment of knee arthritis patients. It provides a certain basis for the treatment of patients with knee arthritis. This article selected 100 knee patients, who, as research subjects, visited our facility for medical treatment between June 2016 and June 2020, and divided 100 patients into two groups, 50 patients in the experimental group and 50 patients in the control group. For patients, the experimental group used nanotubes combined with ethnic sports rehabilitation therapy to treat patients, and the control group used ethnic sports rehabilitation therapy to treat patients. The experimental results show that nanotubes combined with ethnic sports rehabilitation therapy can speed up the treatment process of patients with knee arthritis. When the experiment lasted only 5 days, patients in the control group scored an average of 3 points, and on the last day, they scored an average of 6.9 points. In the experimental group, the average score of patients on the fifth day of the experiment was 5 points, and the average score of patients on the last day was 9.7 points. The knee joint patients in the experimental group have higher walking ability, up‐and‐down ability, knee flexion, and knee swelling. In the control group, among them, the first to recover from knee arthritis is the ability to walk, and the slowest recovery is the flexion of the knee joint.
Golden Ager Chyawanprash with Meager Evidential Base from Human Clinical Trials
Authors: Sharma Rohit , Kakodkar Pradnya , Kabra Atul , Prajapati Pradeep Kumar
Published: May 2022

Chyawanprash (CP) is one of the most revered, effective, and best-selling health supplements of Indian Ayurvedic system of medicine, which is high on the trust and health quotient among Indian consumers. CP is an ancient synergistic blend of around fifty (50) medicinal herbs, herbal extracts with jam-like consistency, traditionally used to improve respiratory health, strengthen the immune system, prevent recurrence of infections, and over the decades is known for its anti-inflammatory and antioxidant properties. With the recent growth of commercialization, this traditional preparation is gaining popularity across the world. Various pharma firms are engaged in its commercial production, and this recipe is easily available on market shelves, with a common brand name “Chyawanprash.” The consumers generally pop up with some genuine queries or doubts regarding its usage and benefits. Though CP is well-trusted traditional preparation, however, limited scientific literature is available on understanding its clinical role. This critical review discusses the general consumer queries apropos its usage, critically analyzing the reported clinical studies, perspectives, and unmapped areas for future research.
Factors Affecting Visual Prognosis of Myopic Foveoschisis after Macular Buckling
Authors: Zhao Xiujuan , Wang Yanbing , Chen Yuqing , Tanumiharjo Silvia , Wu Yijin , Lian Ping , Chen Shida , Huang Xia , Liu Bingqian , Lu Lin
Published: May 2022

Purpose. To analyze the visual prognosis of macular buckling in patients with high myopia foveoschisis (FS) and to identify factors that predict the final visual outcome. Methods. We retrospectively included 155 eyes of 155 patients who underwent foveoschisis-related macular buckling. Best-corrected visual acuity (BCVA) and coexisting macular pathologies were assessed as a measure of surgical outcome, and multivariate linear regression was performed to identify factors affecting final visual prognosis. Results. The mean preoperative BCVA was 1.19 ± 0.55 logMAR (20/308), while the mean postoperative BCVA was 0.82 ± 0.51 logMAR (20/133) (

P
<
0.001

). Anatomical success was achieved in 151/155 eyes (97.42%) after the first surgery and in 155/155 eyes (100%) at the 2-year follow-up visit. Both preoperative and postoperative BCVA were better in eyes without macular hole (MH) than in eyes with MH. In patients with MH, the postoperative BCVA was significantly better than that before surgery when the MH was closed. However, the difference was not significant in patients with unclosed MH. Univariate analysis identified that baseline BCVA, age, MH, atrophic myopic maculopathy category, and postoperative intraretinal cyst were significantly related to BCVA at the postoperative 2-year follow-up. Multivariate analysis revealed that preoperative BCVA and age were significant factors. Conclusion. Better preoperative BCVA and younger age are predictors of better prognosis. Prompt surgery is advised for patients with myopic foveoschisis to improve their visual prognosis.
Hydrochemical Characteristics and Genetic Analysis of Shallow High-Fluorine Groundwater in Fuyang River Basin
Authors: Zhai Zhiwei , Zhang Chuanda , Tang Tiansong , Zhang Chunyan , Bao Xing , Li Kunchao , Han Bo
Published: May 2022

In order to understand the sustainable and effective utilization of groundwater resources in Fuyang River Basin, the chemical characteristics and genetic evolution process of characteristic shallow fluoride groundwater in the region were carried out. The results show that the chemical characteristics of groundwater are zonal in horizontal direction. From the piedmont plain to the central plain, the hydrochemical types of the first and second aquifers are mainly HCO3-Ca-Mg-type water, HCO3-Cl-Ca-Mg-type water, Cl-SO4-Na-Ca-type water, and Cl-SO4-Na-Mg-type water. The main mineral sources of hydrochemical ions are salt rock, carbonate rock, sulfate rock, and silicate rock. F- has a significant positive correlation with HCO3- while it is negatively correlated with K+. In the strong evaporation and alkaline environment created by climatic conditions in the study area, F- mainly comes from the dissolution of minerals. Gypsum and fluorite are in a relatively stable dissolved state continuously providing F- and Ca2+ for groundwater; the adsorption of cation was gradually strengthened from the piedmont plain to the central plain. The high HCO3- content is also conducive to F- desorption in alkaline environments. The samples with F- concentration greater than 1 mg·L-1 accounted for 35.7% and mainly distributed in the south of the study area. In summary, the chemical characteristics of shallow groundwater in Fuyang River Basin are affected by the combined effects including leaching effect, evaporation concentration, ion exchange-desorption, and human factors.
Claudin-12 Deficiency Inhibits Tumor Growth by Impairing Transendothelial Migration of Myeloid-Derived Suppressor Cells
Authors: Cao Hong , Ni Chen , Han Le , Wang Ruoqi , Blasig Rosel , Haseloff Reiner , Qin Yue , Lan Jie , Lou Xiaohan , Ma Pan , Yao Xiaohan , Wang Linlin , Wang Fei , Zhu Linyu , Lei Ningjing , Blasig Ingolf E. , Qin Zhihai
Published: May 2022

Migration of myeloid-derived suppressor cells (MDSC) out of the circulation, across vascular walls, and into tumor is crucial for their immunosuppressive activity. A deeper understanding of critical junctional molecules and the regulatory mechanisms that mediate the extravasation of MDSCs could identify approaches to overcome cancer immunosuppression. In this study, we used mice deficient in tight junction protein Claudin-12 (Cldn12) compared with wild-type mice and found that loss of host Cldn12 inhibited the growth of transplanted tumors, reduced intratumoral accumulation of MDSCs, increased antitumor immune responses, and decreased tumor vascular density. Further studies revealed that Cldn12 expression on the cell surface of both MDSCs and endothelial cells (EC) is required for MDSCs transit across tumor vascular ECs. Importantly, expression of Cldn12 in MDSCs was modulated by GM-CSF in an AKT-dependent manner. Therefore, our results indicate that Cldn12 could serve as a promising target for restoring the antitumor response by interfering with MDSCs transendothelial migration.

Significance:

Claudin-12–mediated homotypic interactions are critical for migration of myeloid-derived suppressor cells across vascular walls into tumor tissue, providing a potential therapeutic approach to overcome cancer immunosuppression.
Measurement of Body Composition in Pancreatic Cancer: A Systematic Review, Meta-Analysis, and Recommendations for Future Study Design
Authors: Griffin Oonagh M. , Bashir Yasir , O’Connor Donal , Peakin Joseph , McMahon Jean , Duggan Sinead Noelle , Geoghegan Justin , Conlon Kevin C.
Published: May 2022

Background/Objectives: Sarcopenia in pancreatic cancer may increase the risk of chemotherapy-related toxicity and post-operative morbidity. This systematic review and meta-analysis aimed to quantify the prevalence of sarcopenia in early stage pancreatic cancer. Methods: Relevant studies were identified using Ovid Medline and Elsevier Embase. Pooled estimates of prevalence rates (percentages) and corresponding 95% confidence interval (CI) were computed using a random-effects model to allow for heterogeneity between studies. Results: The majority of the 33 studies (n = 5,593 patients) included in this meta-analysis utilized computed tomography (CT)-derived measures for body composition assessment in patients undergoing pancreatic resection. Reported prevalence of sarcopenia varied between 14 and 74%, and the pooled prevalence was 39% (95% CI: 38–40%) Heterogeneity was considerable, however, (I2 = 93%) and did not improve significantly when controlling for assessment method, and use of pre-defined cut-offs for sarcopenia, limiting potential to evaluate the true impact of sarcopenia. Conclusion: The ready availability of sequential CT offers a valuable opportunity for body composition assessment, but the quality of assessment and interpretation must improve before the impact of body composition on treatment-related outcomes and survival can be assessed. We suggest recommendations for the assessment of body composition for the design of future studies.
Pathophysiology and Clinical Management of Autoimmune Encephalitis-Associated Seizures
Authors: Zhu Shaofang , Yu Jiabin , Wu Youliang , Peng Ju , Xie Xuemin , Zhang Xiaojing , Xie Haitao , Sui Lisen
Published: May 2022

Seizures are a very common manifestation of autoimmune encephalitis (AE), ranging from 33% to 100% depending on the antigen, most often accompanied by other clinical features such as behavioral changes, movement disorders, memory deficits, autoimmune disturbances, and altered levels of consciousness. Unusual seizure frequency, resistance to antiepileptic treatment, and often, definitive response to immunotherapy emphasize the importance for neurologists to consider the probable etiology of immune disorders. Studies on pathogenic mechanisms of autoantibodies have improved the understanding of different pathophysiologies and clinical characteristics of different AE groups. In encephalitis with antibodies to neuronal extracellular antigens, autoantibodies play a direct role in disease pathogenesis. They have access to target antigens and can potentially alter the structure and function of antigens but induce relatively little neuronal death. Prompt immunotherapy is usually very effective, and long-term antiepileptic treatment may not be needed. In contrast, in encephalitis with antibodies against intracellular antigens, autoantibodies may not be directly pathogenic but serve as tumor markers. These autoantibodies cannot reach intracellular target antigens and are considered to result from a T-cell-mediated immune response against antigens released by apoptotic tumor cells, which contain nerve tissue or express neuronal proteins. Neuronal loss is frequently described and predominantly induced through cytotoxic T-cell mechanisms. They often exhibit an inadequate response to immunotherapy and require early tumor treatment. Long-term antiepileptic treatment is usually needed. In conclusion, each neural autoantibody can specifically precipitate seizures. Early proper management of these cases may help prevent neurological deterioration and manage the occurrence of seizures. Consequently, confirmation of the presence of neuronal autoantibodies is strongly recommended even in patients with confirmed AE, as they are not only essential in achieving a good outcome but also may provide evidence for underlying neoplasia.
The Utility of Systemic Immune-Inflammation Index for Predicting Contrast-Induced Nephropathy in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Karauzum Irem , Karauzum Kurtulus , Hanci Kaan , Gokcek Dogus , Kalas Beyza , Ural Ertan
Published: May 2022

Objective: The systemic immune-inflammation index (SII), derived from counts of neutrophils, platelets, and lymphocytes, has been developed to predict clinical outcomes in several cancers and cardiovascular diseases. The aim of this study was to evaluate the utility of SII to predict contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). Methods: A total of 632 patients with STEMI who underwent primary PCI were retrospectively included. The patients were divided into two groups based on the presence or absence of CIN. Baseline demographic, laboratory, and clinic characteristics were evaluated between the two groups. Logistic regression analysis was used to identify independent predictors of CIN. Results: The receiver operating characteristic curve analysis demonstrated that the optimal cutoff value of SII for predicting CIN was 1,282 with a sensitivity of 76.1% and specificity of 86.7% (AUC: 0.834; 95% CI: 0.803–0.863; p < 0.001). Multivariate analysis performed in two models (SII; as separate continuous and categorical variables) showed age, estimated glomerular filtration rate (eGFR), diabetes, left ventricular ejection fraction (LVEF), Killip class ≥2, use of an intravenous diuretic, troponin I, and SII as independent predictors of CIN in model 1. In model 2, age, eGFR, diabetes, LVEF, Killip class ≥2, use of an intravenous diuretic, troponin I, and a value of SII >1,282 (p < 0.001, OR 6.205, 95% CI: 2.301–12.552) remained as independent predictors of CIN. Conclusion: SII may be a useful and reliable indicator to predict the development of CIN in patients with STEMI undergoing primary PCI than NLR and PLR.
O lugar do tabaco: cachimbo e xamanismo Mbya Guarani
Authors: Pereira Vicente Cretton
Published: May 2022

Este artigo busca estudar o uso do cachimbo e do tabaco entre os Mbya Guarani. Trata-se de um dispositivo central na comunicação com as divindades, mas que também é utilizado cotidianamente em ambientes onde esta relação não estaria (a princípio) em pauta. A análise do material etnográfico colhido pelo autor e a sua comparação com outros contextos ameríndios estabelece um campo semântico definido pelo pensamento mbya a partir do cachimbo e do tabaco buscando mostrar o que estes itens comunicam para além da relação com as divindades. Neste percurso passa-se pelo papel do cachimbo e do tabaco no sistema de trocas de feitiço entre as unidades locais mbya e também pela importância dos mesmos para a produção da pessoa mbya. Neste sentido conclui-se que gradientes de distância e de temperatura orientam de modo marcante o xamanismo mbya.
Alternativas kaiowa e guarani para um impasse na reflexão de Egon Schaden
Authors: Santos Augusto Ventura dos
Published: May 2022

O presente artigo visa discutir um aspecto central dos escritos do antropólogo Egon Schaden sobre as populações guarani: a relação com o mundo não indígena. Num primeiro momento, pretendo reconstituir brevemente a argumentação geral de Schaden a respeito o tema, que diagnostica “um dilema insolúvel”, para a qual a “única alternativa possível” seria “a resignação” dos Guarani (Schaden, 1969: 117). Num segundo momento, proponho confrontar este diagnóstico, mostrando que, longe da resignação, as populações guarani conseguiram construir alternativas importantes no bojo da relação com os brancos que não estavam previstas em análises do tipo. Para embasar teórica e descritivamente este ponto, pretendo remeter às reflexões do intelectual kaiowa Eliel Benites, contidas em sua dissertação de mestrado (Benites, 2014), que indicam outra maneira indígena de lidar com os brancos, não ressaltada por Schaden em razão da análise deste último estar fundamentada na noção de aculturação.
Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial
Authors: Fabris Enrico , Berta Balasz , Roleder Tomasz , Hermanides Renicus S. , IJsselmuiden Alexander J.J. , Kauer Floris , Alfonso Fernando , von Birgelen Clemens , Escaned Javier , Camaro Cyril , Kennedy Mark W. , Pereira Bruno , Magro Michael , Nef Holger , Reith Sebastian , Roleder-Dylewska Magda , Gasior Pawel , Malinowski Krzysztof , De Luca Giuseppe , Garcia-Garcia Hector M. , Granada Juan F. , Wojakowski Wojciech , Kedhi Elvin
Published: May 2022

Background:

Autopsy studies have established that thin-cap fibroatheromas (TCFAs) are the most frequent cause of fatal coronary events. In living patients, optical coherence tomography (OCT) has sufficient resolution to accurately differentiate TCFA from thick-cap fibroatheroma (ThCFA) and not lipid rich plaque (non-LRP). However, the impact of OCT-detected plaque phenotype of nonischemic lesions on future adverse events remains unknown. Therefore, we studied the natural history of OCT-detected TCFA, ThCFA, and non-LRP in patients enrolled in the prospective multicenter COMBINE FFR-OCT trial (Combined Optical Coherence Tomography Morphologic and Fractional Flow Reserve Hemodynamic Assessment of Non-Culprit Lesions to Better Predict Adverse Event Outcomes in Diabetes Mellitus Patients).

Methods:

In the COMBINE FFR-OCT trial, patients with diabetes and ≥1 lesion with a fractional flow reserve >0.80 underwent OCT evaluation and were clinically followed for 18 months. A composite primary end point of cardiac death, target vessel-related myocardial infarction, target-lesion revascularization, and hospitalization for unstable angina was evaluated in relation to OCT-based plaque morphology.

Results:

A total of 390 patients (age 67.5±9 years; 63% male) with ≥1 nonischemic lesions underwent OCT evaluation: 284 (73%) had ≥1 LRP and 106 (27%) non-LRP lesions. Among LRP patients, 98 (34.5%) had ≥1 TCFA. The primary end point occurred in 7% of LRP patients compared with 1.9% of non-LRP patients (7.0% versus 1.9%; hazard ratio [HR], 3.9 [95% CI, 0.9–16.5];
P
=0.068; log rank-
P
=0.049). However, within LRP patients, TCFA patients had a much higher risk for primary end point compared with ThCFA (13.3% versus 3.8%; HR, 3.8 [95% CI, 1.5–9.5];
P
<0.01), and to non-LRP patients (13.3% versus 1.9%; HR, 7.7 [95% CI, 1.7–33.9];
P
<0.01), whereas ThCFA patients had risk similar to non-LRP patients (3.8% versus 1.9%; HR, 2.0 [95% CI, 0.42–9.7];
P
=0.38). Multivariable analyses identified TCFA as the strongest independent predictor of primary end point (HR, 6.79 [95% CI, 1.50–30.72];
P
=0.013).

Conclusions:

Among diabetes patients with fractional flow reserve-negative lesions, patients carrying TCFA lesions represent only one-third of LRP patients and are associated with a high risk of future events while patients carrying LRP-ThCFA and non-LRP lesions portend benign outcomes.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02989740.
Socioeconomic Inequalities in Reperfusion Therapy for Acute Ischemic Stroke
Authors: Buus Sine Mette Øgendahl , Schmitz Marie Louise , Cordsen Pia , Johnsen Søren Paaske , Andersen Grethe , Simonsen Claus Ziegler
Published: May 2022

Background:

Reperfusion therapies (thrombolysis and thrombectomy) are of paramount importance for the recovery after ischemic stroke. We aimed to investigate if socioeconomic status (SES) was associated with the chance of receiving reperfusion therapy for ischemic stroke in a country with tax-funded health care.

Methods:

This nationwide register-based cohort study included patients with ischemic stroke registered in the Danish Stroke Registry between 2015 and 2018. SES was determined by prestroke educational attainment, income level, and employment status. Data on SES was obtained from Statistics Denmark and linked on an individual level with data from the Danish Stroke Registry. Risk ratios (RR) for receiving reperfusion therapies were calculated using univariate and multivariable Poisson regression with robust variance.

Results:

A total of 37 187 ischemic stroke patients were included. Low SES, as defined by education, income and employment status, was associated with lower treatment rates. The socioeconomic gradient was most pronounced according to employment status, with intravenous thrombolysis rates of 23.7% versus 15.8%, and thrombectomy rates of 5.1% versus 2.8% for employed versus unemployed patients. When the analyses were restricted to patients with timely hospital arrival, and adjusted for age, sex and immigrant status, low SES according to income and employment remained unfavorable for the likelihood of receiving intravenous thrombolysis: adjusted RR, 0.90 (95% CI, 0.86–0.95) for low versus high income, and adjusted RR, 0.77 (95% CI, 0.71–0.84) for unemployed versus employed patients. Similarly, low SES according to income and employment status remained unfavorable for the likelihood of receiving thrombectomy: adjusted RR, 0.83 (95% CI, 0.72–0.95) for low versus high income and adjusted RR, 0.68 (95% CI, 0.53–0.88) for unemployed versus employed patients.

Conclusions:

Socioeconomic inequalities in reperfusion treatment rates among ischemic stroke patients prevail, even in a country with tax-funded universal health care.
End-to-end Argument Mining with Cross-corpora Multi-task Learning
Authors: Morio Gaku , Ozaki Hiroaki , Morishita Terufumi , Yanai Kohsuke
Published: May 2022

Mining an argument structure from text is an important step for tasks such as argument search and summarization. While studies on argument(ation) mining have proposed promising neural network models, they usually suffer from a shortage of training data. To address this issue, we expand the training data with various auxiliary argument mining corpora and propose an end-to-end cross-corpus training method called Multi-Task Argument Mining (MT-AM). To evaluate our approach, we conducted experiments for the main argument mining tasks on several well-established argument mining corpora. The results demonstrate that MT-AM generally outperformed the models trained on a single corpus. Also, the smaller the target corpus was, the better the MT-AM performed. Our extensive analyses suggest that the improvement of MT-AM depends on several factors of transferability among auxiliary and target corpora.
Taxonomic studies on the genus Reevesia (Malvaceae: Helicteroideae) I: the identities of R. thyrsoidea
Authors: FENG HUI-ZHE , MENG KAI-KAI , WANG LONG-YUAN
Published: May 2022

In this study, Reevesia botingensis, R. formosana, R. lancifolia, R. lofouensis, R. longipetiolata, R. macrocarpa, R. parvifolia, R. pycnantha, and R. shangszeensis are recognized as R. thyrsoidea through consulting protologues and herbarium specimens. The present investigation provides complete taxonomic treatments, geographic distributions and ecological observations of R. thyrsoidea. And lectotypes of two names have been designated in this article.
Zeravschania sola (Apiaceae), a new species from Mazandaran Province, Northern Iran
Authors: LYSKOV DMITRY , ZARRE SHAHIN , TERENTIEVA ELENA , SAMIGULLIN TAHIR , KLJUYKOV EUGENE
Published: May 2022

A new species, Zeravschania sola (Apiaceae), is described from the Mazandaran Province, Northern Iran. The new species is recognized by molecular phylogenetic analysis of nrITS as closely related to Z. khorasanica and Z. minjanensis. At the same time, it differs from the above-mentioned species in the stem height and diameter at the base, shape of sheaths, leaf blades size, primary and terminal segments of leaves, and umbel size.
Nephoanthus (Melastomataceae: Sonerileae), a new genus segregated from Phyllagathis s.l., with a new species from Southern Vietnam
Authors: LIN CHE-WEI , HSU TIAN-CHUAN , LUU HONG TRUONG , YANG TSUNG-YU ALECK , LI CHIA-WEI
Published: May 2022

A new genus, Nephoanthus, is established based on morphological and molecular data. It comprises two species distributed in montane forests of central to southern Vietnam and Hainan Island: the type species N. prostratus and a new species N. nubigenus. Nephoanthus is morphologically similar to Phyllagathis but phylogenetically remote from the type species of Phyllagathis in the analyses of both plastid genome and nrITS sequences. Nephoanthus is genetically associated to but significantly morphologically distinct from Driessenia, Heteroblemma, Medinilla and Tigridiopalma. A detailed morphological comparison of Nephoanthus and related taxa is provided.
Typification issues in Euphorbia section Plagianthae (Euphorbiaceae)
Authors: HAEVERMANS THOMAS , HETTERSCHEID WILBERT L. A.
Published: May 2022

Euphorbia section Plagianthae contains only two highly distinctive accepted species of Malagasy endemic Euphorbia, restricted to the arid southern part of the island. In this paper we propose an epitype for Euphorbia plagiantha, and a lectotype for Euphorbia fiha, a name designated as a synonym of Euphorbia plagiantha. We also designate a lectotype for Euphorbia salota, and present a distribution map for the section in Madagascar.
Cirsium lipskyi (Asteraceae) is reinstated for C. interpositum, and C. chrysolepis is a new synonym of C. nishiokae
Authors: JIN ZI-CHAO , CHEN YOU-SHENG
Published: May 2022

Through the examination of specimens (including type materials), we proved that Cirsium chrysolepis is indistinguishable from C. nishiokae, and C. lipskyi is conspecific with C. interpositum and is the legitimate early name for the species. Therefore, we relegate C. chrysolepis to the synonymy of C. nishiokae and C. interpositum to the synonymy of C. lipskyi.
GSK-3β RNAi Lentivirus Affects Neuronal Damage and Nuclear Factor E2-Related Factor 2 (Nrf2) Expression in Cerebral Infarction Rats
Authors: Wang Lei , Wang Feng , Wang Yue , Liu Yuxiang , Liu Deshui
Published: May 2022

We investigated the effect of GSK-3β RNAi lentivirus on neuronal damage and Nrf2 level in rats with cerebral infarction. 40 rats were assigned into sham group, CI group, Vector group and GSK-3β RNAi group followed by analysis of cell damage and oxidative stress,
neurological scores, cerebral infarction volume, and brain water content as well as brain morphology by H&E staining and Nrf2 protein level by Western blot. Compared with sham group, GSK-3β mRNA in neurons of CI group and Vector group was significantly elevated (P <
0.05) with reduced level in GSK-3β RNAi group (P < 0.05); 3 hours after surgery, there was no change in neuroethology scores of rats in CI group, Vector group and GSK-3β RNAi group (P > 0.05). While 1 and 3 days later, the scores of rats were significantly
improved (P < 0.05) and brain water content was reduced in GSK-3β RNAi group (P < 0.05) without difference between CI group and Vector group (P > 0.05). Compared with sham group, infarct size in CI group and Vector group was increased (P <
0.05) and reduced in GSK-3β RNAi group (P < 0.05) without difference between CI group and Vector group (P > 0.05). Meanwhile, CI group and Vector group showed significantly downregulated Nrf2, Srx1 and Trx1 proteins (P < 0.05), which were increased
in GSK-3β RNAi group (P < 0.05). In conclusion, GSK-3β RNAi lentivirus can promote the expression of Nrf2 and exert an inhibitory effect on neurons of rats with cerebral infarction, therefore protecting brain tissue.
miR-144-3p Derived from Bone Marrow Mesenchymal Stem Cells (BMSCs) Restrains the Drug Resistance of Acute Myeloid Leukemia (AML)
Authors: Wu Jun , Xie Yingying , Han Limei
Published: May 2022

This study assessed whether miR-144-3p derived from BMSCs restrains the drug resistance of AML. Our study intends to assess miR-144-3p’s role in AML drug resistance. Drug resistance AML cells were transfected with miR-144-3p mimic or NC followed by measuring miR-144-3p level,
relation of miR-144-3p with Wnt, cell activity and apoptosis by flow cytometry and the expression of signal proteins by Western Blot. The action of miR-144-3p in inducting drug resistance of K562/AND was more effective. Cell apoptosis and proliferative index was increased by overexpression
of miR-144-3p along with significantly down regulated Wnt. In conclusion, the malignant invasion of AML with drug resistance is increased by miR-144-3p derived from BMSCs through regulating the Wnt/β-catenin signal, indicating that miT-144-3p might be a new target for the treatment
of AML.
Bone Marrow Mesenchymal Stem Cells (BMSC) Carried with miR-338 Improve BMSC Homing in Intestinal Mucosa of Inflammatory Bowel Disease (IBD) Rats Through Increasing C-X-C Chemokine Receptor Type 4 (CXCR-4)
Authors: Lu Na , Yu Miao , Feng Lipeng
Published: May 2022

This study assessed whether bone marrow mesenchymal stem cells (BMSC) carried with miR-338 improve its homing in intestinal mucosa of IBD rats. Fifty SD rats were equally and randomly assigned into control set, model set, miR-338 set, CXCR-4 Inhibitor set and positive control set followed
by analysis of miR-338 expression, body weight, DAI grade, pathological changes of distal colonic tissue, ultra-microstructure of intestinal epithelium, level of IL-8, IL-10, TGF-β1, VEGF, and CXCR4, as well as the relation between miR-338 and CXCR-4. miR-338 in decorated BMSC
was significantly upregulated. Body weight in model set and CXCR-4 Inhibitor set was lowest followed by miR-338 set and positive control set. However, opposite results were obtained for DAI grade. IL-8 level was highest and IL-10 was lowest in model set and CXCR-4 Inhibitor set. The BMSC carried
with miR-338 exerted recovery action on the intestinal mucosa of IBD rats and inhibited the activity of inflammatory cells. In conclusion, BMSC carried with miR-338 develops recovery action on the intestinal mucosa of IBD rats possibly through regulation of CXCR4, indicating that miR-338 might
be a target for the treatment of IBD.
One-Pot Synthesis Bodipy Nano-Precipitations for Prostate Cancer Treatment
Authors: Wang Jianan , Tian Chao , Cao Zhengguo
Published: May 2022

Here in this study, we proposed a polystyrene maleic anhydride (PSMA) stabilized Bodipy nanoparticles (PB NPs) in a one-pot approach for the photodynamic therapy (PDT) of prostate cancer. The nanoparticle formed by precipitation method was then employed to treat PC-3 cells and PC-3
tumor bearing nude mice model. It was shown that this platform showed promising anticancer performance than free bodipy with reduced side effects.
Identification of Core Genes and Prognostic Models of Laryngeal Cancer by Autophagy Related Biomarkers
Authors: Zou Zirou , Zhao Wenmin , Liang Jiajian , Chen Mingtao , Yu Feng
Published: May 2022

Background: The aims of our article were to identify the core genes of the autophagy-related genes (ARGs) which abnormally expressed in laryngeal cancer (LC) and constructed a risk prognostic models with these genes.Methods: In this study, we identified genes with abnormally expressed in LC, and they were mainly involved in some cancer-related gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes pathways (KEGG). Statistical analysis were conducted to identify the powerful independent prognostic factors associated with clinical factors and survival.Results: A total of 35 DEGs were identified in our research. The risk prediction model was constructed with three potential prognostic genes (VEGFA, SPNS1 and CCL2) of autophagy by lasso regression analysis that can successfully predict the prognosis in LC. We applied ROC curve to evaluate the effectiveness of the risk prognostic model, and found that AUC was 0.693 below the curve. Risk prediction model was only related to survival status (P< 0.01), and was not related to clinicopathological factors. Furthermore, the genes (VEGFA and CCL2) were considered as core genes not only because they were the highly connected genes but also they were the composed genes of risk prognostic model.Conclusions: Taken together, ARGs were considered as important roles in the progression of LC and the prognostic model can help to identification of new targets to guide the diagnosis and therapy.