bluuebunny/crossref_metadata_2025 huggingface dataset:
Posttraumatic stress disorder and depression in coronavirus disease-2019 survivors among resident doctors
Authors: Jadhav Akshay Kailasrao , Jaitpal Varun , Faye Abhijeet , Tadke Rahul , Gawande Sushil , Kirpekar Vivek , Bhave Sudhir
Published: May 2023

Background:

Posttraumatic stress disorder (PTSD) is a severe but treatable mental disorder that usually develops after a life-threatening traumatic event. Coronavirus disease-2019 (COVID-19) especially when the patient requires hospitalization can be a potentially traumatic experience. Many people experienced it to be physically as well as emotionally exhausting and suffered from symptoms suggestive of PTSD. Secondary depression may also occur due to losses and suffering associated with COVID-19 infection. This study aimed at finding the prevalence of PTSD and depression in COVID-19 survivors.

Materials and Methods:

After permission from the Institutional Ethics Committee, 70 participants (resident medical doctors) who recovered from COVID-19 infection were interviewed after obtaining their written informed consent, along with the semi-structured proforma and the Post-Traumatic Stress Disorder Scale Self Report for DSM 5 (PSS-SR5) and Hamilton Depression Rating Scale (HDRS). Data collected were analyzed statistically and results were obtained.

Results:

Out of 70 participants, 1.42% had PTSD and 2.85% had subthreshold PTSD. The most common symptom of PTSD was unwanted upsetting memories about the time spent during the COVID-19 infection. Approximately 5.7% had depression (HDRS score >7); out of which 75% were males and 25% were females. The most common depressive symptom reported was insomnia. There was a positive correlation between a family history of COVID-19, hospitalization, and PTSD.

Conclusion:

A total of 4.2% participants had PTSD symptoms and 5% had depression. Although the prevalence is less, it is important to assess the patients with COVID-19 even after recovery for the development of psychiatric disorders like PTSD and depression so as to intervene at the earliest.
ChatGPT and its application in the field of mental health
Authors: Bhattacharyya Ranjan , Chakraborty Kaustav , Neogi Rjarshi
Published: May 2023

Chat generative pretrained transformer (ChatGPT) was designed by American start-up OpenAI designed in 2015, since its formal introduction on December 6, 2022 it had 1 million users in just more than a month and has become a hot topic of discussion. It will be interesting to find through research work whether ChatGPT can provide us with a comprehensive search and supersedes its earlier competitors such as Google Assistant, Alexa, and Siri. It was beyond wild imagination to everyone how the conversational robot was capable of understanding questions and answering them with superb accuracy. The application of ChatGPT in the field of medical sciences is intriguing and promises to open a new arena. As other systems of communication, Chatbot should be applied in medical sciences maintaining ethical concerns and remembering that, at times, ChatGPT can give inaccurate and wrong answers.
Assessment of Knowledge, Attitude, Awareness, and Opinion of Patients on Routine Dental Services During Covid-19 Pandemic
Authors: Kothiwale Shaila V. , Andrews Alpana , Mehta Komal , Hugar Shweta Shivayogi
Published: May 2023

Background:

The novel severe acute respiratory syndrome-coronavirus-2 virus has undoubtedly disrupted the life of every individual and created a global health and economic crisis. Health-care systems, including dental clinics, were affected and patients with dental pain suffered since they were unable to seek dental care at the right time. It has since become relevant to examine and understand the outlook and views of patients toward seeking routine dental services and their acceptance of alternative methods of dental practice through the COVID-19 pandemic. Hence, this cross-sectional questionnaire study was conducted to assess the knowledge, attitude, and opinion of patients visiting a dentist for routine dental services during the COVID-19 pandemic

Methodology:

A cross-sectional questionnaire-based survey was conducted among 200 patients who visited the dental college for their treatment. Their responses were recorded and descriptive analysis, Chi-square test, and multiple logistic regression analysis were carried out to evaluate their responses.

Results:

The participants were aware of the transmission of COVID-19 (91%), 64% believed it was safe to visit a dentist and 99.5% believed it necessary to take proper precautions before visiting the dentist. Participants (84%) preferred having dental consultations over phone/email/video calls compared to regular in-person consultations during the pandemic.

Conclusion:

Teledentistry has the potential to emerge as an effective mode of managing patients with dental needs to reduce the burden on dental clinics and hospitals. It can ensure the accessibility to dental care even in the remotest area by allowing patients to connect with dentists through appropriate digital and social media.
A Study to Assess the Impact of Gender and Psychiatric Distress on Coping Responses and the Levels of Anxiety, Depression, and Suicidal Ideation in Undergraduate Medical Students
Authors: Paul Oindrila , Chaudhuri Arunima , Banerjee Ushri , Paul Kalyan Kumar
Published: May 2023

Background:

Medical education is one of the most stressful academic curricula across the globe, and response to stress can be manifested as physical response, emotional response, cognitive response, and behavioral response.

Aims:

The aim was to study the relationships between coping styles, level of anxiety, level of depression, and level of suicidal ideation in medical students with a special emphasis on gender differences.

Materials and Methods:

This cross-sectional study was conducted on 250 medical students of a medical college in West Bengal. Data were collected using online Google Forms. A pretested structured questionnaire contained five scales, namely General Health Questionnaire-28, Coping Response Inventory, State-Trait Anxiety Inventory, Beck Depression Inventory-II, and Adult Suicidal Ideation Questionnaire.

Results:

Out of 250 students, 63.6% were male. In the case of psychiatric distress, 57.5% of males and 42.5% of females reported no considerable psychiatric distress. Among those with considerable levels of psychiatric distress, majority (68.6%) were male. Most (88%) of the participants exhibited above-average levels of state anxiety and only 0.8% of them exhibited above-average levels of trait anxiety. Moderate-to-severe levels of depression were found in 39.2% of the participants and 27.6% of them reported frequent suicidal ideation. Majority of the participants utilized avoidance coping methods such as cognitive avoidance, acceptance or resignation, seeking alternative rewards, and emotional discharge (ED). ED was found to be the most frequently used coping response.

Conclusions:

Psychiatric distress has a significant impact on the levels of depression, anxiety, suicidal ideation, and coping responses in medical students. Gender had a significant role in the case of suicidal ideation and ED in medical students. Emotion-focused coping is more in use among medical students as compared to approach coping or problem-focused coping.
Inclusion of Competencies Pertaining to Robotic Surgery in the Medical Curriculum
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: May 2023

Robotic surgery has started to emerge as one of the effective and sought-after approaches in the field of surgery in the last couple of decades. The quick adoption and propagation of robotic surgery is primarily because of the numerous benefits attributed to the same. The purpose of the current review was to explore the inclusion of competencies pertaining to robotic surgery within the undergraduate and postgraduate medical curriculum. An extensive search of all materials related to the topic was carried out in the PubMed search engine and a total of 16 articles were selected based upon the suitability with the current review objectives and analyzed. In the current set-up, the majority of the medical colleges don't offer much to their undergraduate or postgraduate surgical residents in terms of exposure to robotic surgery. However, considering that sooner or later, every future medical student or resident will have an encounter with a patient who has already undergone a robotic surgery or will be undergoing the same, we have to ensure formal introduction in the teaching curriculum. In conclusion, the future of robotic surgery is changing and it is finding numerous applications in different surgical streams. Acknowledging the scope of the same, as medical educators, it is our responsibility to introduce in the curriculum, provide adequate number of learning opportunities and supplement with periodic assessments for a better patient care.
Bacterial Meningitis as the First Presentation of Multiple Myeloma
Authors: Zutushi Sasmita , Shukla Samarth , Acharya Sourya , Bhawane Amol , Mishra Preeti , Singh Satyam
Published: May 2023

Multiple myeloma (MM) is a monoclonal gammopathy. Patients with MM are vulnerable to infections, especially by encapsulated bacteria. These infections have been associated with severe morbidity and mortality in MM. A key underlying cause of the immune system's decline in MM is insufficient production of polyclonal immunoglobulin, which manifests as severe hypogammaglobulinemia. An acute bacterial infection is rarely the first sign of the disease. We present a case of a 65-year-old male who presented to us with fever and disorientation. Clinical examination revealed signs of meningeal irritation. Cerebrospinal fluid study confirmed bacterial meningitis. Associated features such as renal failure, high erythrocyte sedimentation rate, hyperglobulinemia, and anemia lead to suspicion of MM which was later confirmed by serum electrophoresis.
A Study on Predictors of Nomophobia Among Undergraduate Medical Students of a Tertiary Care Teaching Institute in Kolkata, West Bengal
Authors: Basu Mausumi , Shukla Vineeta , Maulik Sanghamitra , Kerketta Prince , Bysack Ratul Kumar
Published: May 2023

Background and Objectives:

Undergraduate medical students are more prone to develop stress, anxiety, and depression; and COVID-19 is an additional source of pressure for them. The present study was conducted with the objectives to estimate the proportion of nomophobia among undergraduate medical students of a tertiary care teaching institute in Kolkata and to find the factors associated with it.

Materials and Methods:

An observational study, cross-sectional in design, was conducted at a tertiary care teaching institute in Kolkata among 395 undergraduate medical students for a period of 8 weeks. Nomophobia Questionnaire scale was used to measure nomophobia. Data were analyzed using the SPSS software version 25.0. Multivariable multinomial logistic regression was performed to find the predictors of moderate and severe nomophobia.

Results:

All the medical students had some degree of nomophobia. About 26.8% of them had severe nomophobia, 61.3% had moderate nomophobia, and 11.9% had mild nomophobia. Age up to 20 years and the presence of addiction had statistically significant higher odds of severe nomophobia. Age up to 20 years, the presence of addiction, and up to 6 h' time spent per day with smart phone had significantly higher odds of moderate nomophobia.

Conclusion:

There was a high proportion of nomophobia among young budding doctors. Those who have already got moderate nomophobia should use smart phones more wisely and judiciously and avoid downloading addictive applications.
Empowerment Status of School-Going Adolescents in Anekal Taluk of Bengaluru District
Authors: Kalliath Jacob Davies , Gnanaselvam Nancy Angeline , Pinto Nihal Xavier , Chirayath Michael , Ramesh Naveen
Published: May 2023

Context:

Empowerment is a multidimensional social process that enables vulnerable population to participate in and control the various determinants of health. This study was done to assess the empowerment status and factors associated with it among school-going adolescents in Anekal Taluk, Bangalore Urban District.

Materials and Methods:

It was a cross-sectional study. The sample included government school-going adolescents between 14-18 years of age. Study tools used were self-designed expert validated questionnaire on adolescent empowerment. Data were entered on EpiData and analyzed by SPSS version 16.0.

Results:

Among the 351 study participants, 196 (56%) were females and 188 (58%) were in 10th and 11th standards. In health domain, 186 (53%) of the students were aware about at least two nutritious foods and 317 (90.3%) of the students knew to cook food on their own; 271 (77.2%) of the students knew how to start a bank account and 307 (87.5%) knew what to do in a hospital when they are sick; 328 (93.6%) of students believe that minimum age for marriage for females was between 18-20 years and 329 (93.7%) knew at least one method of family planning; 282 (80.3%) of the students knew at least one vocational skill; 21 (6%) knew about child protection laws and 203 (58%) believe that decisions regarding important life events should be taken by both parents in conjunction with children.

Conclusions:

Adolescents lacked empowerment in terms of knowledge regarding reproductive health and nutrition. Years of schooling was found to be associated with better empowerment.
Incidence of Adverse Drug Reactions Among Elderly Patients
Authors: Hadia Rajesh , Joshi Dhaval , Bhil Dipika , Maheshwari Rajesh
Published: May 2023

Background:

Several studies suggest that adverse drug reactions (ADRs) are commonly seen among hospitalized elderly and found common causes of hospital admission leading to substantial morbidity and mortality among elderly. However, no meta-analysis was conducted till date to estimate the overall incidence of ADRs among elderly.

Objectives:

To estimate the overall incidence of ADRs in elderly patients, incidence of ADRs in elderly in different health-care settings, incidence of serious ADRs in elderly patients, and the continent-wise incidence of ADRs in elderly patients.

Design:

Meta-analysis and systematic review.

Methodology:

Studies were identified through searching different databases such as MEDLINE, Cochrane Database of Systematic Reviews, Google Scholar, Clinical Key, and Scopus (published from 1980 to October, 2015) and by hand searching the reputed journals on geriatrics and gerontology and references of the included articles. Original peer-reviewed research articles published in English, defined ADRs according to the WHO's or similar definition and assessed the incidence of ADRs in elderly or having sufficient raw data to determine the incidence were included. Disease- or treatment-specific studies were excluded. Before meta-analysis, the studies were evaluated for heterogeneity using Chi-square and I
2 statistics. The overall incidence of ADRs among the elderly with 95% confidence interval (CI) was determined using a random-effects model (DerSimonian and Laird method). Subgroup analyses were performed based on study settings and continent where the studies conducted. All the analyses were carried out using Review Manager (RevMan, version: 5.3) software.

Results:

Of the 5747 articles retrieved, only 56 and 54 articles were included for systematic review and meta-analysis, respectively. The overall incidence (95% CI) of ADRs among elderly population was 12.94%. The health-care setting-wise overall incidences of ADRs in the elderly were 17.53%, 19.54%, and 6.92% in inpatients, outpatients, and patients hospitalized due to ADRs, respectively. The continent-wise overall incidences of ADRs in elderly were 12.15%, 22.94%, 12.34%, and 18.76% in Asia, Australia, Europe, and USA, respectively. Electrolyte disorders and skin rashes were the common manifestations of the drugs. Cardiovascular drugs and NSAIDs were the most common causative drugs for the ADRs among elderly. Polypharmacy was the major risk factor for ADRs in elderly population, irrespective of the type of health-care settings and continents.

Conclusions:

The incidence of ADRs in the elderly was higher and is a significant health-care burden in the elderly. Appropriate prescribing, proper compliance, and monitoring for ADRs are needed to decrease the incidence of ADRs in elderly patients.
Strengthening the Process of Implementation of Coaching in Medical Education Settings
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: May 2023

The branch of medicine is quite complex and it requires a wide range of teaching–learning innovations, student support activities, and faculty motivation to ensure that the goals of medical education are accomplished. The purpose of the current review is to explore the role of coaching in improving the learning and skill acquisition in the field of medical education. An extensive search of all materials related to the topic was carried out in the PubMed search engine and a total of 22 articles were selected based on the suitability with the current review objectives. The ultimate aim of coaching in medical education is to unearth the real potential of the students to optimize their performance by helping them to learn instead of teaching them. Coaching is a strategy to help medical students to become competent and reflective practitioner. In addition, coaching plays an important role in the refinement of technical skills (like surgical skills) and nontechnical skills. To conclude, coaching in medical education has significant scope to improve the learning outcomes among students and even make them lifelong learners. The need of the hour is to implement a coaching system in each of the medical colleges after considering the local logistics and with the active support of faculty members.
Awareness about Cigarette- and Tobacco-Related Legislation among College Students of Belagavi City
Authors: Yadav Saroj Kumar , Narasannavar Ashwini , Bhattarai Shubhechchha
Published: May 2023

Background:

In 2003, the COTPA act was enacted to control and prohibit tobacco use all over India. It has focused on advertisement, prohibition of sale of tobacco products to below 18 years individual, etc., Objective: The objective was to determine the awareness of cigarette and tobacco legislation among college students of Belagavi city.

Materials and Methods:

A pre-post study was conducted, comprising 101 urban participants and 96 rural participants of average age 17.35 ± 0.657 years in colleges in and around Belagavi taluka. The students were selected randomly. The awareness on COTPA was assessed using a pretested structured questionnaire before and after an educational intervention. Paired t-test was calculated to identify the difference in the pre- and post-test awareness scores.

Results:

The mean age of the participants was 17.35 ± 0.657 years. The pretest and posttest awareness scores among the urban participants was 8.22 ± 2.982 and 11.80 ± 1.995, respectively. Similarly, the pretest and posttest awareness scores among the rural participants was 10.28 ± 1.845 and 12.67 ± 0.496, respectively. The result showed a significant difference in pre- and post-test scores, indicating increase in awareness of both urban and rural participants after an effective interventional program.

Conclusion:

The study concludes that the health education had a good impact on awareness on COTPA among all participants.
Coronavirus Disease 2019 Pandemic
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: May 2023

The coronavirus disease-2019 (COVID-19) pandemic has stretched the health system beyond their capacity & capability. The initial evidence has suggested that the infection is transmitted from one person to another through close contacts and droplets and thus the role of infection prevention strategies is extremely important. It has been advocated that frequent and proper maintenance of hand hygiene can prove to be the most effective strategy to prevent infection acquisition. However, in order to maintain hand hygiene, it is ideal to have access to safe water, sanitation and hygienic (WASH) facilities, as this will significantly reduce the risk of the transmission of infection between humans. Thus, all steps should be taken to ensure that improved WASH facilities and waste management provisions are available at home, education institutions, workplaces, community and health care establishment. In conclusion, the provision of standard WASH facilities in all the settings is critical to strengthen hand hygiene practices and thereby plays a significant role in reducing the risk of acquisition of infection and thus the caseload of COVID-19.
Study of Thyroid Profile and Prolactin Levels in Female Infertility Patients
Authors: Kundu Sonia , Rao Sudhamani S , Singh Kritika , Rao Rajiv
Published: May 2023

Introduction:

Thyroid as an endocrine organ along with prolactin hormone plays a significant role in the fecundity of the couple. Disorders in these hormones may cause menstrual abnormalities and anovulation, leading to infertility. Its dysfunction is not uncommon and is often reversible or preventable with early detection and treatment. This study was undertaken to study the occurrence of thyroid hormone dysfunction and hyperprolactinemia in infertile women.

Materials and Methods:

In this study, we studied the thyroid profile and prolactin levels in 100 infertile women who visited the obstetrics and gynecology department or in vitro fertilization center of a tertiary care hospital. The frequency of hypo- and hyperthyroidism along with hyperprolactinemia was studied, and the association between thyroid dysfunction and levels of serum prolactin was analyzed.

Results:

The majority of the infertile women were euthyroid. Thyroid dysfunction was noted in 27% of infertile women, with 17% showing hyperthyroidism and 10% showing hypothyroidism. Hyperprolactinemia was observed in 9% of infertile females. Hypothyroidism was found to be positively associated with hyperprolactinemia.

Conclusion:

Blood examination for thyroid hormone and prolactin should be kept in consideration as important routine workup in female infertility patients so that patients can be appropriately managed.
Cross-Cultural Adaptation and Validation of Gujarati Version Knee Injury and Osteoarthritis Outcome Score for Patellofemoral Subscale for Early Patellofemoral Osteoarthritis Population
Authors: Patel Heta Pavan , Balaganapathy M.
Published: May 2023

Context:

The condition of knee pain is common across Gujarat state but identification of joint structure involvement is burdensome in the early cases. The earliest symptom/s patients reported early are anterior knee pain and difficulty in weight-bearing activities. By reviewing the related literature, the researcher states that these symptoms frame the involvement of patellofemoral joints. A dialect tool is not available to evaluate the symptoms of Gujarati speaking population. Knee Injury and Osteoarthritis Outcome Score for patellofemoral (KOOS-PF) scale was developed in the year 2018 using COSMIN guidelines for spotting patellofemoral disorders. It was a valid tool published in the English language.

Aims:

The study aimed to cross-culturally adapt and validate of KOOS-PF scale in the Gujarati language for the early patellofemoral arthritis population.

Settings and Design:

This validation study was carried out in six regional orthopedic hospitals.

Subjects and Methods:

A translation and cross-cultural adaptation process was conducted using Beaton D. 2002 guidelines. It was administered to 144 early patellofemoral arthritis patients to determine the psychometric properties.

Results:

A total of 144 participants with a mean age of 46.61 ± 4.31 were recruited. The internal consistency measures showed low Cronbach's alpha (α = 0.124). The participants completed the second administration of the Gujarati version scale for good test–retest reliability, r = 0.938. There were no floor and ceiling effects. The convergent validity was confirmed with a moderate negative correlation with Gujarati version modified Western Ontario and McMaster Universities Arthritis Index (r = −0.527). Factor analysis explained that the scale was loaded on three factors.

Conclusions:

The analysis identified deficits in reliability and convergent validity of the Gujarati version of the KOOS-PF scale suggestive of the development of a new condition-specific tool for the early cases which can be used in research and clinical practice.
Rural South Indian spirometry values show wide variation compared to existing prediction equations
Authors: Christopher Devasahayam J. , Oommen Anu M. , George Kuryan , Premkumar Prasanna Samuel , Shankar Deepa , Agrawal Anurag , Thangakunam Balamugesh
Published: May 2023

Background and Objective:

India, a highly heterogeneous country, has no common reference standards for predicting spirometry values, with very few recent studies from south India. This study aimed to create reference equations for rural south Indian adults, based on a population-based survey in Vellore, south India and compare it with other equations from India.

Methods:

The data from 583 non-smoking, asymptomatic participants (30 years and older) from a spirometry-based survey for airflow obstruction (rural Vellore, 2018), were used to develop equations for FEV1, FEV1/FVC, and FVC. The dataset was divided for development (70%) and validation (30%), by gender. Differences between observed and predicted values were assessed using the new equations and comparisons made with other equations from India.

Results:

Predictions with Vellore rural equations were closest to the previous south Indian equations from urban Bangalore. However, the Bangalore equations led to overestimation of FVC values in males, and of both FEV1 and FVC values in females. Using the rural Vellore equations also led to a higher percent of males being classified as having airflow obstruction, compared to the Bangalore equations which underestimated airflow obstruction in this rural population. Comparison with previously derived Indian equations from other parts of the country showed pronounced variations.

Conclusions:

Our study reiterates the need for representative rural and urban studies of adults from various parts of India, to obtain region specific reference equations, given the wide variations in spirometry values in “normal” individuals, due to social heterogeneities of the Indian population and resulting complexities in defining normal.
Ultrasonography in cardiopulmonary emergencies
Authors: Gudivada Kiran Kumar , Krishna Bhuvana , Narayan Shiva Kumar
Published: May 2023

The utilization of ultrasound has rapidly increased over the past few decades due to its ease of use, wider availability of portable machines, broad applicability, non-invasiveness, and real-time imaging. A varied spectrum of clinical conditions such as diverse lung pathologies and various etiologies of acute circulatory failure can be rapidly ascertained using bedside ultrasonography. It has been shown that lung ultrasonography has more sensitivity than chest x-ray in detecting pulmonary congestion in heart failure, subpleural lung consolidation in pneumonia, and characterizing and detecting even minimal pleural effusions. This review gives an overview of the application of ultrasonography in the evaluation of cardiopulmonary failure which is the most commonly encountered clinical entity in the emergency room (ER). The most feasible bedside tests to predict fluid responsiveness are described in this review. Lastly, essential ultrasonographic protocols that are useful for systematic examination of critically ill patients were presented.
ARID1A Mutation from Targeted Next-Generation Sequencing Predicts Primary Resistance to Gemcitabine and Cisplatin Chemotherapy in Advanced Biliary Tract Cancer
Authors: Lee Sung Hwan , Cheon Jaekyung , Lee Seoyoung , Kang Beodeul , Kim Chan , Shim Hyo Sup , Park Young Nyun , Jung Sanghoon , Choi Sung Hoon , Choi Hye Jin , Lee Choong-kun , Chon Hong Jae
Published: May 2023

Purpose There are clinical unmet needs in predicting therapeutic response and precise strategy for the patient with advanced biliary tract cancer (BTC). We aimed to identify genomic alterations predicting therapeutic response and resistance to gemcitabine and cisplatin (Gem/Cis)-based chemotherapy in advanced BTC.Materials and Methods Genomic analysis of advanced BTC multi-institutional cohorts was performed using targeted panel sequencing. Genomic alterations were analyzed integrating patients’ clinicopathologic data, including clinical outcomes of Gem/Cis-based therapy. Significance of genetic alterations was validated using clinical next-generation sequencing (NGS) cohorts from public repositories and drug sensitivity data from cancer cell lines.Results 193 BTC patients from three cancer centers were analyzed. Most frequent genomic alterations were TP53 (55.5%), KRAS (22.8%), ARID1A (10.4%) alterations, and ERBB2 amplification (9.8%). Among 177 patients with BTC receiving Gem/Cis-based chemotherapy, ARID1A alteration was the only independent predictive molecular marker of primary resistance showing disease progression for 1st-line chemotherapy in the multivariate regression model (odds ratio, 3.12; p=0.046). In addition, ARID1A alteration was significantly correlated with inferior progression-free survival on Gem/Cis-based chemotherapy in the overall patient population (p=0.033) and in patients with extrahepatic cholangiocarcinoma (CCA) (p=0.041). External validation using public repository NGS revealed that ARID1A mutation was a significant predictor for poor survival in BTC patients. Investigation of multi-OMICs drug sensitivity data from cancer cell lines revealed that cisplatin-resistance was exclusively observed in ARID1A mutant bile duct cancer cells.Conclusion Integrative analysis with genomic alterations and clinical outcomes of the first-line Gem/Cis-based chemotherapy in advanced BTC revealed that patients with ARID1Aalterations showed a significant worse clinical outcome, especially in extrahepatic CCA. Well-designed prospective studies are mandatory to validate the predictive role of ARID1Amutation.
Deformation classification of quartic surfaces with simple singularities
Authors: Güneş Aktaş Çisem
Published: May 2023

We give a complete equisingular deformation classification of simple spatial quartic surfaces which are in fact

K3

-surfaces.
An exploration of barriers and career strategies of female leaders in Nepalese higher education.
Authors:   , Mainali Sarada
Published: May 2023

Although more women are entering the labour force in Nepal, women’s representation in leadership positions remains significantly low. The reasons for women’s under-representation have not been researched in the Nepalese context; therefore, the full story remains untold and women’s voices are still unheard. Thus, this research aims in providing a voice to those who are unheard by exploring the barriers faced by women leaders of higher education in Nepal through their lived stories and experiences. Moreover, this study also seeks to understand the strategies adopted by successful women leaders to manoeuvre their way into leadership positions. Social role theory, role congruity theory and feminist theory guided this qualitative study. Semi-structured interviews were conducted with 12 women leaders (department heads and above) at two large universities in Nepal. Although several studies have been conducted around the globe but the social and cultural aspects of life in Nepal are different, therefore, researchers argue that the problems cannot be generalised. The findings of this study showed various social, organisational and personal barriers such as patriarchal culture, masculine culture, work-life balance issues, gender stereotypes, negative attitudes, and lack of confidence and determination contributing to women's under-representation in Nepalese higher education. The findings of this study go beyond confirming the existence of role expectations: women are not just expected to play their gender-based roles; they also face criticism for sharing their roles. Similarly, this study also contributes a new argument to the literature; namely, that the mother-in-law plays a substantial role in contributing to women’s career progression. The outcome of the study also showed that successful Nepalese female leaders are changing their way of leadership based on their survival needs. Therefore, this study also proposes a new leadership theory “survival leadership” to define the leadership of Nepalese female leaders. This study also recommends various measures that can be implemented to improve women’s representation in leadership positions in Nepalese higher education.
Do conteúdo à temática da Educação Financeira: uma análise de indicadores do conhecimento da população e da proposta curricular brasileira
Authors: Prais Jacqueline Lidiane de Souza , Saraiva Elihebert , Fonseca Odair  José Teixeira da
Published: May 2023

A temática curricular da Educação Financeira passou a ser exigida com a aprovação da Base Nacional Comum Curricular (BNCC), fixando conteúdos a serem contemplados na formação do estudante da Educação Básica, em especial, no Ensino Médio. Esta pesquisa parte do seguinte problema: De que modo, a temática da Educação Financeira tem sido contemplada nos indicadores de conhecimento da população e na proposta curricular brasileira? Elenca como objetivos apresentar indicadores quanto ao conhecimento da população com os conceitos da educação financeira e analisar o conceito de Educação Financeira nos documentos curriculares. Adota como procedimentos metodológicos a análise documental aliada à análise de conteúdo, tendo como fonte os relatórios do Banco Central do Brasil, os Parâmetros Curriculares Nacionais (PCN’s), as Diretrizes Curriculares Nacionais (DCN’s) e a BNCC. Dentre os principais resultados e discussão, destaca que as orientações didáticas quanto ao ensino da temática educação financeira se distanciam de uma proposta que vise mudança de comportamento da sociedade que deveriam estar alicerçados nos conhecimentos da Matemática aplicados à uma Educação Financeira.
Grupos de/com Pesquisa em Educação Matemática no Brasil: Notas Históricas, Áreas Predominantes e Linhas de Pesquisa
Authors: Alves Carlos Alex , Silva Leandro Londero da
Published: May 2023

Analisamos a constituição de grupos de/com pesquisa em Educação Matemática no Brasil. Os aportes teórico-metodológicos vinculam-se a literatura específica da Educação, Educação Matemática e da pesquisa descritiva de levantamento com abordagem quanti-qualitativa. A Fonte de dados consultada foi o Diretório dos Grupos de Pesquisa no Brasil do CNPq, sendo validado um total de 569 grupos de pesquisa a partir de alguns comandos específicos de busca. As variáveis analisadas foram as Grandes Áreas, Áreas e linhas de pesquisa. Os resultados apontaram que os grupos apresentam integralmente ou parcialmente linhas de pesquisa vinculadas a Educação Matemática e estão locados principalmente nas Grandes Áreas/Áreas Ciências Humanas/Educação e Ciências Exatas e da Terra/Matemática; agregam, em média, quatro linha de pesquisa, sendo as de maior interesse Ensino e Aprendizagem, Formação de Professores e Tecnologias. Por fim, realçamos uma agenda de investigação que possa privilegiar estudos vindouros em torno da nossa região investigativa.
O Brasil por Imagens: Darcy Ribeiro com Glauber Rocha
Authors: Meireles Ildenilson , Rodrigues Soares Clarissa
Published: May 2023

O artigo explora, a partir do encontro de Darcy Ribeiro com Glauber Rocha, certo campo imagético do Brasil que circula nos dois autores a fim de destacar uma visão mais radical dos problemas sociais do país desde as várias imagens textuais e cinematográficas produzidas pelas obras desses dois intelectuais brasileiros. Nossa aposta é que o encontro de Darcy com Glauber e o encantamento recíproco sintetizou a expectativa de ambos em relação à imagem de um Brasil profundo desconhecido do seu próprio povo.
Suspected Doxycycline Induced Acute Interstitial Nephritis
Authors: Abrahamian Andrew , Burmeister Cameron , Hejeebu Srini
Published: May 2023

Please view the PDF To see the formatted meeting abstract.
Venous Stent Migration to the Heart: Case Report and Review of the Literature
Authors: Waack Andrew
Published: May 2023

Please view the PDF To see the formatted meeting abstract.
Hypercalcemia in the Inpatient Setting:
Authors: Chinnam Sahithi
Published: May 2023

Please view the PDF To see the formatted meeting abstract.
Room Temperature Water Infusion during Colonoscopy Insertion Induces Rectosigmoid Colon Mucus Production
Authors: El Rahyel Ahmed
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
Early Feeding Versus Delayed Feeding after Therapeutic Endoscopic Intervention in Upper GI Bleeding:
Authors: Sayeh Wasef
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
Efficacy and Safety of Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Severe Carotid Stenosis:
Authors: Patel Neha
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
Worsening Pericardial Effusion Despite Intensive Hemodialysis
Authors: Royfman Rachel
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
Knowledge, Attitude and Practices of Women Towards Breast Cancer in Arbaji Village, Gezira State, Sudan
Authors: Salih Ayman
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
The Impact of Sacubitril / Valsartan Versus ACE/ARB Therapy on Functional Capacity in Heart Failure with Preserved Ejection Fraction
Authors: Yassen Mohammad
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
The Dominant Negative IQGAP1(IR-WW) Domain as a Potential Therapy in Brain Cancer
Authors: Osman Mahasin
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
Immunotherapeutic Interventions in Carcinoid Tumors
Authors: Nigro Anthony
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
Efficacy and Safety of EUS-directed Transgastric ERCP (EDGE) vs Laparoscopic-Assisted ERCP:
Authors: Gangwani Manesh
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
Myasthenic Crisis-Induced Takotsubo Cardiomyopathy:
Authors: Gayfield Scott
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
Fatal central pontine myelinolysis in a patient with uncontrolled HIV and normal sodium levels
Authors: Kammeyer Joel
Published: May 2023

Please view the PDF to see the formatted meeting abstract.
REGULASI PEMERINTAH INDONESIA UNTUK MENYELAMATKAN PEREKONOMIAN INDONESIA PADA MASA PANDEMI COVID-19
Authors:   Universitas Methodist Indonesia, Goh Thomas Sumarsan , Sagala Edison ,   Universitas Negeri Medan
Published: May 2023

COVID-19 tidak hanya berdampak pada kesehatan manusia tetapi juga menyerang perekonomian di Dunia termasuk Indonesia. Pemerintah mengeluarkan fasilitas perpajakan dan aturan omnibus law, yang memberikan penyederhanaan dan harmonisasi regulasi dan perizinan, penciptaan lapangan kerja berkualitas dan kesejahteraan pekerja yang berkelanjutan dan pemberdayaan UMKM. Pemerintah yang dapat menurunkan suku bunga sehingga daya beli masyarakat meningkat dan juga para pengusaha dapat melakukan ekspansi usahanya yang pada akhirnya menyerap tenaga kerja.
PENGARUH FINANCIAL DISTRESS, UKURAN KAP DAN OPINI AUDIT, TERHADAP AUDITOR SWITCHING PADA PERUSAHAAN PERTAMBANGAN YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors:   Universitas Methodist Indonesia, Elisabeth Duma Megaria
Published: May 2023

Penelitian ini bertujuan untuk menguji pengaruh Financial Distress, Ukuran KAP dan Auditor Switching terhadap auditor switching pada perusahan pertambangan yang terdaftar di Bursa Efek Indonesia.Populasi dalam penelitian ini adalah 49 perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia periode 2016-2020. Teknik pengambilan sampel yang digunakan adalah purposive sampling, diperoleh 18 sampel perusahaan yang memenuhi kriteria selama lima tahun pengamatan dengan total 90 unit analisis. Data penelitian diperoleh dari laporan tahunan dan laporan keuangan secara lengkap dan telah diaudit oleh auditor independen dari perusahaan sampel yang diunduh dari website BEI www.idx.co.id. Teknik analisis data dan pengujian hipotesis dalam penelitian ini menggunakan analisis statistik deskriptif dan analisis regresi logistik.Hasil penelitian ini menunjukkan bahwa Financial Distress berpengaruh positif dan signifikan terhadap auditor switching, Ukuran KAP berpengaruh negatif dan signifikan terhadap auditor switching dan Opini Audit berpengaruh positif dan tidak signifikan terhadap auditor switching.
ANALISIS KEBIJAKAN CORPORATE SOCIAL RESPONSIBILITY DALAM MANAJEMEN LABA
Authors:   Universitas Methodist Indonesia, Rumapea Melanthon , Purba Dimita H. P. , Ratnawati Ratnawati
Published: May 2023

Penelitian ini bertujuan untuk menganalisis Kebijakan Corporate Social Responsibility (CSR) dalam Manajemen Laba. Penelitian ini dilakukan pada salah satu Badan Usaha Milik Negara (BUMN) yaitu PT. Perkebunan Nusantara V untuk menganalisis Kebijakan CSR dalam manajemen laba diperusahaan tersebut. Data yang dianalisis adalah data sekunder yang berbentuk Laporan Tahunan pada periode 2016-2018, berupa laba tahun berjalan dan penjualan bersih perusahaan pada periode tersebut. Penelitian ini bersifat deskriptif dengan menggunakan prosedur pengumpulan data melalui observasi, wawancara dan studi pustaka serta kajian secara deskriptif yaitu dengan mengumpulkan dan menganalisis data yang sesuai dengan laporan keuangan tahunan yang disajikan mengenai CSR dan Manajemen Laba. Hasil analisis menunjukkan bahwa kebijakan CSR tidak berpengaruh dan tidak memiliki hubungan terhadap manajemen laba. CSR juga tidak mempengaruhi laba tahun berjalan perusahaan penjualannya.
Ser semillerista en red: rutas histórico-administrativas de la Fundación Redcolsi
Authors: Gallardo Cerón Blanca Nelly
Published: May 2023

El presente libro Ser Semillerista en Red: Rutas histórico-administrativas de la Fundación Redcolsi, es resultado del estudio de documentos administrativos en la tesis doctoral Sentidos y perspectivas de los semilleros de investigación colombianos, hacia la lectura de una experiencia latinoamericana y que continúa en el 2017 como revisión analítica en el marco del proyecto de investigación interinstitucional «Impacto de los semilleros de investigación en Antioquia», adscrito al grupo de investigación SER (Servicio Educativo Rural), con el aval del Sistema de Investigación y Desarrollo de la Universidad Católica de Oriente. Este libro se terminó de preparar en el Fondo Editorial Universidad Católica de Oriente, en el mes de diciembre de 2018.​
Psicoterapia y Espiritualidad: El reto de la transformación interior desde Anselm Grün
Authors: Duque López Cristian Fernando
Published: May 2023

La espiritualidad es la dimensión más humana de lo humano. Sin embargo, en el afán de cuantificar, de medir, de predecir, de explicar racionalmente el mundo, desde una lógica cerrada, se ha caído en ocasiones en el olvido de esta dimensión, dejando de lado el potencial que se encuentra allí para la felicidad y plenitud del hombre. El presente libro trata, de manera profunda y novedosa, la utilidad del manejo de lo espiritual, en un campo tan amplio como el terapéutico, mediante la presentación de la relación entre psicología y espiritualidad, a través de un análisis concienzudo de los planteamientos de Anselm Grün, logrando mostrar, de manera clara, una sistematización de los conocimientos de este autor, que aporta elementos novedosos y valiosos en el campo del conocimiento de la psicología.
Некоторые проблемы классификации мер в рамках механизма ограничения прав личности в досудебном производстве
Authors: Кобулов Бекзод
Published: May 2023

В статье излагаются новые механизмы, виды классификации процессуальных мер принуждения и следственных действий, связанных с ограничением конституционных прав существующих лиц в уголовно-процессуальном законодательстве. Также описаны конкретные предложения по устранению противоречий, правовых лазеек и некоторых существующих в уголовно-процессуальном законодательстве, касающихся мер принуждения и следственных действий, связанных с ограничением прав личности.
PERFIL SOCIODEMOGRÁFICO, REPRODUTIVO E OBSTÉTRICO DE GESTANTES ADOLESCENTES NO MUNICÍPIO DE PORTO VELHO-RO
Authors: Moreira Alves Kátia Fernanda , Barbosa Andre Lucas Santana , Oliveira da Silva Martins Alinne , Sales Rodrigues Marcos Antônio
Published: May 2023

A adolescência é uma fase de descobertas e amadurecimento físico e mental. Conceber uma gravidez neste momento configura um problema de saúde pública diante dos impactos negativos que podem ocorrer para a gestante e para o feto. Objetivo: investigar o perfil sociodemográfico, reprodutivo e obstétrico em gestantes adolescentes que procuram assistência obstétrica em uma maternidade pública de Porto Velho-RO, Brasil. É um estudo quantitativo, descritivo, de corte transversal, com 58 gestantes adolescentes internadas no alojamento conjunto na maternidade municipal de Porto Velho-RO. A maioria das gestantes possuía idade entre 15 e 19 anos (98%), casadas ou em união estável (66%), sexualmente ativa a partir da faixa etária de 10 a 14 anos (52%); utilizam métodos de barreira como forma de prevenção de infeções sexualmente transmissíveis (86%) e gestações não planejadas (95%). Além disto, encontravam-se desempregadas (59%) e renda familiar menor de um salário-mínimo (62%). Estas constatações demonstram que as gestantes se encontram em situação de vulnerabilidade e que há necessidade do fortalecimento de ações do planejamento reprodutivo, tendo em vista o alto percentual de gravidezes não planejadas, o que nos leva a inferir que as adolescentes não faziam uso deste método quando engravidaram. Concluiu-se que é necessário o enfermeiro e demais membros da equipe buscarem estratégias para o desenvolvimento de ações do planejamento reprodutivo e pré-natal qualificado, visando mitigar a gravidez na adolescência.
AVALIAÇÃO DO POTENCIAL HIDROGÊNIO (PH) DO HIPOCLORITO DE SÓDIO EM TRÊS DIFERENTES MOMENTOS ANTES DO SEU VENCIMENTO
Authors: Dos Santos Pereira Sarah Regina , Pereira Thaís Cristine , Meccatti Vanessa Marques , De Carvalho Lara Steffany , Coser Bridi Enrico , De Oliveira Luciane Dias , Abu Hasna Amjad
Published: May 2023

O hipoclorito de sódio (NaOCl) é o irrigante mais utilizado no tratamento endodôntico, tendo sido introduzido na endodontia na última metade do século XVIII. O objetivo deste estudo foi avaliar a estabilidade do pH do hipoclorito de sódio (de diferentes concentrações) e solução salina em três momentos diferentes. O pH dos irrigantes foi medido em triplicata usando um medidor de pH Mettler Toledo SevenEasy S20 (Mettler-Toledo AG. Analytical Instruments. Schwerzenbach, Suíça) em três momentos: S1: ao desembalar o frasco da solução; S2: um mês depois; e S3: quatro meses depois. Os dados foram submetidos a testes de normalidade. Em seguida, foram analisados ​​pelos testes One-way Anova e Tukey pelo GraphPad Prism 6 (La Jolla, CA, EUA) com nível de significância de 5%. Verificou-se que houve diferença estatisticamente significativa entre os grupos Hipoclorito de Sódio 1% e 2,5% em comparação com os grupos soro fisiológico e água destilada em S1, S2 e S3. Além disso, constatou-se que o hipoclorito de sódio 1% perde seu pH alcalino desde o primeiro mês. No entanto, o hipoclorito de sódio 2,5% foi mais estável após 4 meses. Concluiu-se que o tempo de armazenamento tem efeito na estabilidade do pH do hipoclorito de sódio 1%.