bluuebunny/crossref_metadata_2025 huggingface dataset:
Knockdown of DJ-1 Resulted in a Coordinated Activation of the Innate Immune Antiviral Response in HEK293 Cell Line
Authors: Zohar Keren , Linial Michal
Published: July 2024

PARK7, also known as DJ-1, plays a critical role in protecting cells by functioning as a sensitive oxidation sensor and modulator of antioxidants. DJ-1 acts to maintain mitochondrial function and regulate transcription in response to different stressors. In this study, we showed that cell lines vary based on their antioxidation potential under basal conditions. The transcriptome of HEK293 cells was tested following knockdown (KD) of DJ-1 using siRNAs, which reduced the DJ-1 transcripts to only 12% of the original level. We compared the expression levels of 14k protein-coding transcripts and 4.2k non-coding RNAs relative to cells treated with non-specific siRNAs. Among the coding genes, approximately 200 upregulated differentially expressed genes (DEGs) signified a coordinated antiviral innate immune response. Most genes were associated with the regulation of type 1 interferons (IFN) and the induction of inflammatory cytokines. About a quarter of these genes were also induced in cells treated with non-specific siRNAs that were used as a negative control. Beyond the antiviral-like response, 114 genes were specific to the KD of DJ-1 with enrichment in RNA metabolism and mitochondrial functions. A smaller set of downregulated genes (58 genes) was associated with dysregulation in membrane structure, cell viability, and mitophagy. We propose that the KD DJ-1 perturbation diminishes the protective potency against oxidative stress. Thus, it renders the cells labile and responsive to the dsRNA signal by activating a large number of genes, many of which drive apoptosis, cell death, and inflammatory signatures. The KD of DJ-1 highlights its potency in regulating genes associated with antiviral responses, RNA metabolism, and mitochondrial functions, apparently through alteration in STAT activity and downstream signaling. Given that DJ-1 also acts as an oncogene in metastatic cancers, targeting DJ-1 could be a promising therapeutic strategy where manipulation of the DJ-1 level may reduce cancer cell viability and enhance the efficacy of cancer treatments.
Modeling and Simulation of a 2SPU-RU Parallel Mechanism for a Prosthetic Ankle with Three Degrees of Freedom
Authors: Abarca Victoria E. , Elias Dante A.
Published: July 2024

To assist an individual with an amputation in regaining daily quality of life, a 2SPU-RU type parallel mechanism was developed based on ankle biomechanics. The inverse kinematic analysis of this mechanism was performed using the vector method. Subsequently, the Jacobian matrices were analyzed. The dynamic model of the mechanism was then created based on the principle of virtual work, and its theoretical solution was compared with numerical results obtained in a simulation environment. Additionally, the validity of the dynamic model and the inverse kinematics was verified by comparing theoretical and simulation results for the movements of plantarflexion–dorsiflexion, eversion–inversion, and abduction–adduction during the gait cycle.
TCAD Modelling of Magnetic Hall Effect Sensors
Authors: Pandey Vartika , Marsic Vlad , Igic Petar , Faramehr Soroush
Published: July 2024

In this paper, a gallium nitride (GaN) magnetic Hall effect current sensor is simulated in 2D and 3D using the TCAD Sentaurus simulation toolbox. The model takes into account the piezoelectric polarization effect and the Shockley–Read–Hall (SRH) and Fermi–Dirac statistics for all simulations. The galvanic transport model of TCAD Sentaurus is used to model the Lorentz force and magnetic behaviour of the sensor. The current difference, total current, and sensitivity simulations are systematically calibrated against experimental data. The sensor is optimised using varying geometrical and biasing parameters for various ambient temperatures. This unintentionally doped ungated current sensor has enhanced sensitivity to 16.5 %T−1 when reducing the spacing between the drains to 1 μm and increasing the source to drain spacing to 76 μm. It is demonstrated that the sensitivity degrades at 448 K (S = 12 %T−1), 373 K (S = 14.1 %T−1) compared to 300 K (S = 16.5 %T−1). The simulation results demonstrate a high sensitivity of GaN sensors at elevated temperatures, outperforming silicon counterparts.
Comprehensive Utilization of Fossil Energy: Fabrication of Fire-Retardant Building Materials from Waste Plastic
Authors: Wang Zheng , Geng Long , Zhao Jiateng , Qiao Wenyuan , Liu Changhui
Published: July 2024

As one of the most common fossil derivatives, plastics are widely used for their exceptional chemical stability, low density, and ease of processing. In recent years, there has been a significant increase in the production of waste plastics, coupled with a low recycling rate, resulting in serious environmental pollution. To enhance the use of waste plastics, this research synthesized flame-retardant materials from hypercrosslinked polystyrene with different molar fractions of flame retardants. Waste polystyrene foam was used as the raw material, while aniline, triphenylphosphine, and melamine were employed as flame-retardant additives. The flame-retardant additives were successfully doped into the porous skeleton structure of hypercrosslinked polystyrene through a chemical reaction or physical mixing to achieve in situ flame retardancy, and the materials were shaped by a phenolic resin prepolymer. Then, the samples were characterized in detail, and the results indicate that the addition of a flame retardant enhances the flame retardancy of the material. In addition, the material has excellent thermal insulation performance, with a minimum thermal conductivity of 0.04176 W/(m·K).
Effects of Layer Thickness and Compaction Thickness on Green Part Density in Binder Jetting Additive Manufacturing of Silicon Carbide: Designed Experiments
Authors: Pasha Mostafa Meraj , Arman Md Shakil , Khan Fahim , Pei Zhijian , Kachur Stephen
Published: July 2024

This paper reports on an experimental investigation that used a full factorial design to study the main effects and the interaction effect of layer thickness and compaction thickness on the green part density in the binder jetting additive manufacturing of silicon carbide. A two-variable, two-level full factorial design was employed. The results show that the green part density was higher at the low level of layer thickness and at the high level of compaction thickness. These results can be useful in selecting the values of printing variables, enabling the fabrication of green parts with a desirable density that is crucial for advanced ceramic applications.
Integrating Future Multi-Scenarios to Evaluate the Effectiveness of Ecological Restoration: A Case Study of the Yellow River Basin
Authors: Huang Xinbei , Ye Chengming , Tao Hongyu , Zou Junjie , Zhou Yuzhan , Zheng Shufan
Published: July 2024

Ecological restoration is an important strategy for mitigating environmental degradation, and the effectiveness evaluation of ecological restoration is of profound significance for the scientific implementation of restoration projects. This study improved the Patch-generating Land Use Simulation (PLUS) model. It was used to simulate the land use patterns under multi-scenarios such as natural development (ND), economic priority (EP), and ecological restoration (ER) in 2030. An evaluation framework covering ecological “Restoration–Monitoring–Effectiveness” (RME) was proposed. Based on 30 m high-resolution remote-sensing data from 2000 to 2020, the land use distribution, landscape pattern changes, and ecosystem services under different scenarios were evaluated and predicted in the Yellow River Basin of Sichuan to verify the effectiveness of the evaluation framework. The results showed the following: (1) Under the ER scenario, the transfer of land use types in 2020–2030 was mainly characterized by an increase in the area of wetlands and a decrease in the area of built-up land. (2) There were obvious differences in land use and landscape patterns under different scenarios. Compared with the ND and EP scenarios, the growth of the construction rate was suppressed in the ER scenario, and the coverage of grassland and wetlands increased significantly. (3) The mean values of ecosystem services in the ER scenario were higher than those in the ND and EP scenarios. These findings clearly indicate that the RME evaluation system can accurately evaluate the ecological restoration effects under multi-scenarios in the future, providing a new perspective for ecological restoration evaluation in other regions.
Effect of Bi2MoO6 Morphology on Adsorption and Visible-Light-Driven Degradation of 2,4-Dichlorophenoxyacetic Acid
Authors: Duong Thi Thanh Hoa , Ding Shuoping , Sebek Michael , Lund Henrik , Bartling Stephan , Peppel Tim , Le Thanh Son , Steinfeldt Norbert
Published: July 2024

The development of highly efficient and stable visible-light-driven photocatalysts for the removal of herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) from water is still a challenge. In this work, Bi2MoO6 (BMO) materials with different morphology were successfully prepared via a simple hydrothermal method by altering the solvent. The morphology of the BMO material is mainly influenced by the solvent used in the synthesis (H2O, ethanol, and ethylene glycol or their mixtures) and to a lesser extent by subsequent thermal annealing. BMO with aggregated spheres and nanoplate-like structures hydrothermally synthesized in ethylene glycol (EG) and subsequently calcined at 400 °C (BMO-400 (EG)) showed the highest adsorption capacity and photocatalytic activity compared to other synthesized morphologies. Complete degradation of 2,4-D on BMO upon irradiation with a blue light-emitting diode (LED, λmax = 467 nm) was reached within 150 min, resulting in 2,4-dichlorophenol (2,4-DCP) as the main degradation product. Holes (h+) and superoxide radicals (⋅O2−) are assumed to be the reactive species observed for the rapid conversion of 2,4-D to 2,4-DCP. The addition of H2O2 to the reaction mixture not only accelerates the degradation of 2,4-DCP but also significantly reduces the total organic carbon (TOC) content, indicating that hydroxyl radicals are crucial for the rapid mineralization of 2,4-D. Under optimal conditions, the TOC value was reduced by 84.5% within 180 min using BMO-400 (EG) and H2O2. The improved degradation performance of BMO-400 (EG) can be attributed to its particular morphology leading to lower charge transfer resistance, higher electron–hole separation, and larger specific surface area.
Novel Application of Metal–Organic Frameworks as Efficient Sorbents for Solid-Phase Extraction of Chemical Warfare Agents and Related Compounds in Water Samples
Authors: Woźniak Jakub , Popiel Stanisław , Nawała Jakub , Szczęśniak Barbara , Choma Jerzy , Zasada Dariusz
Published: July 2024

In this work, we test metal–organic frameworks (MOFs) as sorbents in the solid-phase extraction (SPE) technique to determine chemical warfare agents (CWAs) and their related compounds in water samples. During this study, we used 13 target compounds to test the selectivity of MOFs thoroughly. Three MOFs were used: MIL-100(Fe), ZIF-8(Zn), and UiO-66(Zr). The obtained materials were characterized using FT-IR/ATR, SEM, and XRD. CWA’s and related compounds were analyzed using gas chromatography coupled with tandem mass spectrometry (GC-MS/MS). The effect of the type of elution solvent and the amount of sorbent (MOFs) in the column on the efficiency of the conducted extraction were verified. The LOD ranged from 0.04 to 7.54 ng mL−1, and the linearity range for the analytes tested extended from 0.11/22.62 (depending on the compound) to 1000 ng mL−1. It was found that MOFs showed the most excellent selectivity to compounds having aromatic rings in their structure or a “spread” spatial structure. The best recoveries were obtained for DPAA, CAP, and malathion. Environmental water samples collected from the Baltic Sea were analyzed using an optimized procedure to verify the developed method’s usefulness.
Enzymatic Desymmetrisation of Prochiral meso-1,2-Disubstituted-1,2-Diaminoethane for the Synthesis of Key Enantioenriched (−)-Nutlin-3 Precursor
Authors: Cristofori Virginia , Illuminati Davide , Bisquoli Chiara , Catani Martina , Compagnin Greta , Turrin Giulia , Trapella Claudio , Fantinati Anna
Published: July 2024

Herein we present the biocatalysed preparation of a mono-N-carbamate-protected precursor of antitumoral Nutlin-3a through enantioselective alkoxycarbonylation of meso-1,2-disubstituted-1,2-diaminoethane using enzyme lipases and dialkyl carbonates as acylating agents. A series of supported or free lipase enzymes were screened in combination with commercially available diallyl, diethyl and dimethyl carbonates. The reactions were conducted at different temperatures, for different reaction times and with variable co-solvent systems to evaluate the effects on the enzyme catalytic activity. The best results in terms of conversion, enantiomeric excess and yield were obtained when lipase from Candida antarctica B (CAL-B) was used with diallyl carbonate (DAC) when conducting the reaction solventless at 75 °C.
Spray-Coated Transition Metal Dichalcogenides as Hole Transport Layers in Inverted NFA-Based Organic Photovoltaics with Enhanced Stability under Solar and Artificial Light
Authors: Tountas Marinos , Anagnostou Katerina , Sotiropoulos Evangelos , Polyzoidis Christos , Kymakis Emmanuel
Published: July 2024

In this study, we explored the potential of exfoliated transition metal dichalcogenides (TMDs) as innovative spray-coated hole transport layers (HTLs) in organic photovoltaics (OPVs), addressing the need for efficient and stable materials in solar cell technology. This research was motivated by the need for alternative HTLs that can offer enhanced performance under varying lighting conditions, particularly in indoor environments. Employing UV-visible absorption and Raman spectroscopy, we characterized the optical properties of MoS2, MoSe2, WS2, and WSe2, confirming their distinct excitonic transitions and direct bandgap features. The nanocrystalline nature of these TMDs, revealed through XRD patterns and crystallite size estimation using the Scherrer method, significantly contributes to their enhanced physical properties and operational efficiency as HTLs in OPVs. These TMDs were then integrated into OPV devices and evaluated under standard solar and indoor lighting conditions, to assess their effectiveness as HTLs. The results demonstrated that MoS2, in particular, displayed remarkable performance, rivalling traditional HTL materials like MoO3. It maintained high power conversion efficiency across a spectrum of light intensities, illustrating its versatility for both outdoor and indoor applications. Additionally, MoS2 showed superior stability over extended periods, suggesting its potential for long-term usage in OPVs. This study contributes significantly to the field of photovoltaic materials, presenting TMDs, especially MoS2, as promising candidates for efficient and stable OPVs in diverse lighting conditions, thereby broadening the scope of solar cell applications.
Exploratory Study on Distinguishing Dendrobium Stem and Five Species of Dendrobium Using Heracles Neo Ultra-Fast Gas Phase Electronic Nose
Authors: Dai Yuping , Huang Dan , He Ye , Xiang Yun , Li Shunxiang
Published: July 2024

Dendrobium stem is a valuable food with medicinal and edible properties. Due to its high medicinal value and price, closely related Dendrobium varieties are often sold as imitations on the market. Therefore, there is an urgent need to develop new methods that can quickly identify Dendrobium stem and its closely related species. The Heracles Neo ultra-fast gas phase electronic nose was used in this study to determine and analyze the composition and contents of volatile organic compounds (VOCs) in Dendrobium stem and samples of five other species closely related to it. A total of 20 VOCs were identified, and a fingerprint map of the VOCs was constructed. Principal component analysis (PCA), Euclidean distance, and other methods were used to comprehensively process and analyze the obtained VOC information. The AroChemBase database was also used for qualitative analysis of the compounds. The results showed that there are significant differences in the odor fingerprint spectra of Dendrobium stem and the five other closely related species. The main types of compounds in Dendrobium stem and its five closely related species were organic esters, aldehydes, ketones, and olefins. Among them, 3-methylbutanal and n-butanol were characteristic compounds of the Dendrobium stem sample, while the VOCs acetonitrile and trometamol were present in the five related Dendrobium species samples. The Heracles Neo ultra-fast gas phase electronic nose can quickly and accurately identify Dendrobium stem and its five closely related species. It can also be used for the quality evaluation of Dendrobium stem, providing a theoretical reference for reducing the phenomenon of medicinal confusion in the Dendrobium stem market.
5G Network Deployment Planning Using Metaheuristic Approaches
Authors: Sapkota Binod , Ghimire Rijan , Pujara Paras , Ghimire Shashank , Shrestha Ujjwal , Ghimire Roshani , Dawadi Babu R. , Joshi Shashidhar R.
Published: July 2024

The present research focuses on optimizing 5G base station deployment and visualization, addressing the escalating demands for high data rates and low latency. The study compares the effectiveness of Genetic Algorithm (GA), Particle Swarm Optimization (PSO), Simulated Annealing (SA), and Grey Wolf Optimizer (GWO) in both Urban Macro (UMa) and Remote Macro (RMa) deployment scenarios that overcome the limitations of the current method of 5G deployment, which involves adopting Non-Standalone (NSA) architecture. Emphasizing population density, the optimization process eliminates redundant base stations for enhanced efficiency. Results indicate that PSO and GA strike the optimal balance between coverage and capacity, offering valuable insights for efficient network planning. The study includes a comparison of 28 GHz and 3.6 GHz carrier frequencies for UMa, highlighting their respective efficiencies. Additionally, the research proposes a 2.6 GHz carrier frequency for Remote Macro Antenna (RMa) deployment, enhancing 5G Multi-Tier Radio Access Network (RAN) planning and providing practical solutions for achieving infrastructure reduction and improved network performance in a specific geographical context.
Packed Bed Thermal Energy Storage System: Parametric Study
Authors: Rabi’ Ayah Marwan , Radulovic Jovana , Buick James M.
Published: July 2024

The use of thermal energy storage (TES) contributes to the ongoing process of integrating various types of energy resources in order to achieve cleaner, more flexible, and more sustainable energy use. Numerical modelling of hot storage packed bed storage systems has been conducted in this paper in order to investigate the optimum design of the hot storage system. In this paper, the effect of varying design parameters, including the diameter of the packed bed, the storage material, the void fraction, and the aspect ratio of the packed bed, on storage performance was investigated. COMSOL Multiphysics 5.6 software has been used to design, simulate, and validate an axisymmetric model, which was then applied to evaluate the performance of the storage system based on the total energy stored, the heat transfer efficiency, and the capacity factor. In this paper, a novel-packed bed was proposed based on the parametric analysis. This involved a 0.2 void fraction, 4 mm porous media particle diameter, and Magnesia as the optimum storage material with air as the heat transfer fluid.
ESTIMACIONES DEL OPERADOR MAXIMAL ASOCIADO A MEDIDAS NO DOBLANTES
Authors: Chávez Macías Yoconda Magdalena , Infante Linares Adrián Ramón
Published: July 2024

Este artículo estudiamos la propiedad de acotación del operador maximal de Hardy-Littlewood no centrado , asociado a diferentes tipos de medidas . Una medidas  es doblante si existen constantes  tales que , con   es la bola de de centro  y radio , el operador maximal asociado a una medida doblante es acotado de tipo (1,1). Cuando la medida no es doblante el operador maximal no es necesariamente acotado, por ejemplo el operador maximal asociado a la medida gaussiana, , no es acotado. Damos una extensión del resultado de la acotación del operador maximal definidos sobre todos los cubos de  y asociado a una clase de medidas absolutamente continua con respecto a la medida de Lebesgue, demostrando que el resultado de acotación también se cumple en dimensión mayor y demostramos una desigualdad en cuasi-norma para este caso.
Programas de estimulación temprana para niños dentro del espectro autista durante la pandemia por COVID-19
Authors: Purisaca Soriano Dora Zulema , Colán-Hernández Bryam Alejandro
Published: July 2024

Los programas de estimulación temprana son intervenciones dirigidas a niños con trastornos del desarrollo, como lo es el autismo, estos buscan favorecer la adaptación e integraciónsocial, así como mejorar habilidades cognitivas, comunicativas y emocionales. Sin embargo, la pandemia del COVID-19 fue un gran desafío para la continuidad y la efectividad de estosprogramas, debido a las restricciones de movilidad, el cierre de centros educativos y sanitarios, y el aumento del estrés familiar. En este artículo se revisan los principales estudios que evaluaron el impacto de la pandemia en los programas de estimulación temprana para niños dentro del espectro autista y las estrategias para adaptarlos al contexto actual. Metodología: se realizó una revisión bibliográfica de estudios publicados entre 2020 y 2023 en Scopus, Web of Science, Scielo, Latindex y Google Scholar. Aplicando ecuaciones de búsqueda elaboradas con los descriptores y operadores booleanos: "programas de estimulación temprana”, “trastorno del espectro autista”, “pandemia COVID-19". Se seleccionaron 29 trabajos que cumplieron con los criterios de inclusión como el aborde de programas de estimulación temprana para niños dentro del espectro autista, producto de investigación empírica o teórica sobre el tema. Los resultados coinciden con los de otras investigaciones que han analizado la misma temática. Se concluye que la pandemia afectó negativamente tanto la calidad como la efectividad de los programas de estimulación temprana, elevando la vulnerabilidad de los niños y niñas con TEA, y que es necesario desarrollar e implementar medidas específicas para garantizar el acceso y la atención adecuada a este colectivo vulnerable.
Atención plena para disminuir la sintomatología de TDAH en escolares de Perú
Authors: Lanchipa Cori Jorge Luis , Porras Roque María Soledad , Centella-Centeno Daniel Martin
Published: July 2024

El Trastorno por Déficit de Atención e Hiperactividad se caracteriza por presentar síntomas de inatención, impulsividad e hiperactividad. La estrategia de atención plena puede ser una poderosa herramienta para contrarrestarlo al mejorar la capacidad de atención, concentración y autorregulación emocional. Objetivo. Determinar la efectividad de la atención plena como estrategia para disminuir la sintomatología de TDAH en escolares entre 6 a 12 años de Tacna, Perú. Material y método. Estudio cuantitativo de tipo experimental y corte longitudinal. Se llevó a cabo en el año 2023. La muestra estuvo constituida por 613 escolares pertenecientes a instituciones educativas de la ciudad de Tacna de Cono Norte y Sur. Se recolectó la información mediante la técnica de la encuesta y como instrumento un cuestionario sobre TDAH y uno sobre atención plena, este último usado como pre y post test. Se realizó la prueba de Wilcoxon, con una significancia del 95% y un valor p<0,05 como estadísticamente significativo. Resultados. Tienen nivel alto de inatención el 9,6 %, de impulsividad el 3,1 % y de hiperactividad el 2,3 %. Luego de ejecutarse 10 sesiones basadas en la atención plena, se logró mejor el nivel de satisfacción de un 51,4% (que había en el pre-test) a un 73,6% (en el post-test). Conclusiones. La aplicación de la estrategia de atención plena tuvo un efecto positivo y consistente en la disminución de la sintomatología de TDAH. Estos hallazgos respaldan la implementación de este tipo de intervenciones en el ámbito escolar para beneficiar a los estudiantes con esta condición.
Multifunctional Hydrogels Based on γ-Polyglutamic Acid/Polyethyleneimine for Hemostasis and Wound Healing
Authors: Li Xiuyun , Han Wenli , Zhang Yilin , Tan Dongmei , Cui Min , Wang Shige , Shi Wenna
Published: July 2024

Current hemostatic materials have many shortcomings, such as biotoxicity or poor degradability, and do not effectively promote wound healing after hemostasis. To address these limitations, a hemostasis-promoting wound-healing hydrogel, polyglutamic acid/polyethyleneimine/montmorillonite (PPM), comprising polyglutamic acid, 3,4-dihydroxybenzaldehyde-modified polyethyleneimine, and amino-modified montmorillonite (montmorillonite-NH
2
) was constructed in this study. Due to the excellent water absorption abilities of γ-polyglutamic acid, the PPM and polyglutamic acid/polyethyleneimine hydrogels could rapidly absorb the blood and tissue fluid exuded from the wound to keep the wound clean and accelerate the blood coagulation. The homogeneous distribution of montmorillonite-NH
2
enhanced not only the mechanical properties of the hydrogel but also its hemostatic properties. In addition, the modification of polyethylenimine with 3,4-dihydroxybenzaldehyde provided anti-inflammatory effects and endorsed the wound healing. Cellular and blood safety experiments demonstrated the biocompatibility of the PPM hydrogel, and animal studies demonstrated that the PPM hydrogel effectively stopped bleeding and promoted wound healing. The concept design of clay-based hydrogel may create diverse opportunities for constructing hemostasis and wound-healing dressings.
Ultrasound Controllable Release of Proteolysis Targeting Chimeras for Triple-Negative Breast Cancer Treatment
Authors: He Hongye , Li Feng , Tang Rui , Wu Nianhong , Zhou Ying , Cao Yuting , Wang Can , Wan Li , Zhou Yang , Zhuang Hua , Li Pan
Published: July 2024

Triple-negative breast cancer (TNBC) is a special subtype of breast cancer, which is highly aggressive and incurable. Here, we proposed an ultrasound activatable bromodomain-containing protein 4 (BRD4) proteolysis targeting chimera (PROTAC) release strategy for the first time for precisely controlled protein degradation in preclinical TNBC model. Through combination of PROTAC and ultrasound-targeted microbubble destruction (UTMD) technology, the present strategy also aims to concurrently solve the major limitations of poor loading capacity of microbubbles and undesirable targeting and membrane permeability of PROTAC. PROTAC (ARV-825)-encapsulated microbubbles, ARV-MBs, were developed for the efficacious treatment of TNBC in vitro and in vivo. The microbubbles we synthesized showed ultrasound-responsive drug release ability, which could effectively promote the penetration of PROTAC into tumor site and tumor cell. Under ultrasound, ARV-MBs could play an effective antitumor effect by potentiating the ubiquitination and degradation of BRD4 in tumor. The current study may provide a new idea for promoting clinical translation of drug-loaded microbubbles and PROTAC, and offer a new efficacious therapeutic modality for TNBC.
Deep Learning for Strain Field Customization in Bioreactor with Dielectric Elastomer Actuator Array
Authors: Wang Jue , Sarkar Dhirodaatto , Mohan Atulya , Lee Mina , Ma Zeyu , Chortos Alex
Published: July 2024

In the field of biomechanics, customizing complex strain fields according to specific requirements poses an important challenge for bioreactor technology, primarily due to the intricate coupling and nonlinear actuation of actuator arrays, which complicates the precise control of strain fields. This paper introduces a bioreactor designed with a 9 × 9 array of independently controllable dielectric elastomer actuators (DEAs), addressing this challenge. We employ image regression-based machine learning for both replicating target strain fields through inverse control and rapidly predicting feasible strain fields generated by the bioreactor in response to control inputs via forward control. To generate training data, a finite element analysis (FEA) simulation model was developed. In the FEA, the device was prestretched, followed by the random assignment of voltages to each pixel, yielding 10,000 distinct output strain field images for the training set. For inverse control, a multilayer perceptron (MLP) is utilized to predict control inputs from images, whereas, for forward control, MLP maps control inputs to low-resolution images, which are then upscaled to high-resolution outputs through a super-resolution generative adversarial network (SRGAN). Demonstrations include inputting biomechanically significant strain fields, where the method successfully replicated the intended fields. Additionally, by using various tumor–stroma interfaces as inputs, the bioreactor demonstrated its ability to customize strain fields accordingly, showcasing its potential as an advanced testbed for tumor biomechanics research.
North Korea's Succession of Power andRenewed Successor Debate
Authors: Baek Seung-kuk , Kim Tong-ook ,   Public Policy Research Institute, Korea University
Published: July 2024

North Korea maintains its regime through a three-generation hereditary succession. During the Kim Jong-il era, there was an academic debate over who would become the successor. At that time, Kim Jong-nam and Kim Jong-chul were considered as strong candidates, and Kim Jong-un was not in the spotlight as a potential successor. However, Kim Jong-un is currently ruling North Korea as Kim Jong-il's successor. In November 2022, the succession debate was rekindled when Kim Jong-un publicly introduced his daughter. The renewed debate began with claims that Kim Jong-un's daughter, Kim Ju-ae, had been designated as the successor. The discussions among researchers regarding Kim Ju-ae are inherently exhaustive due to limited information and resources. Therefore, it is important to analyze the implications of Kim Ju-ae's emergence for both South and North Korea, and to consider the future of North Korea under a potential fourth-generation succession. It is likely that Kim Jong-un will implement a fourth-generation succession, and we may continue to face a nuclear-armed North Korea in the future. Thus, the (south korea)government should take action to prevent Kim Jong-un's successor from inheriting nuclear weapons. Additionally, for a research project, it is necessary to discuss the fourth-generation succession and the emergence of Kim Ju-ae based on data obtained from in-depth interviews with North Korean refugees who witnessed her emergence. In conclusion, in the absence of widely accepted information and data, the succession debate is meaningless. At present, it is advisable to focus on the significance of the fourth-generation succession itself, rather than on a specific individual.
Teologi Bambu
Authors: Harun Harun
Published: July 2024

This research aims to formulate a concept of environmentally friendly theology in Toraja. Through a mimetic approach, it was found that bamboo has an essential meaning for the Toraja people but receives little attention. Bamboo is used excessively in implementing the Rambu Solo' and Rambu Tuka' ceremonies due to the Torajan people's lack of understanding of the meaning of bamboo in everyday life. To find the meaning of bamboo and provide a comprehensive understanding, the author uses a mimetic approach to Toraja literature to create a bamboo theology. In this context, bamboo theology appears as a theological concept that wants to tell the story of who God is for the Toraja people: who is present, works, protects, and nurtures through His creation. Bamboo theology was born from the Toraja people's understanding of the importance of bamboo in their entire life journey as part of the community on earth. Bamboo theology is a bridge to see God's creation (humans, animals, and plants) as God's partners in caring for and preserving the universe.
Tujuan penelitian ini adalah untuk merumuskan konsep berteologi yang ramah lingkungan di Toraja. Melalui pendekatan mimetik ditemukan bahwa bambu memiliki makna penting bagi masyarakat Toraja, tetapi kurang diperhatikan. Bambu dipergunakan secara berlebihan dalam pelaksanaan upacara rambu solo’ dan rambu tuka’, karena kurangnya pemahaman masyarakat Toraja tentang makna bambu dalam kehidupan sehari-hari. Untuk menemukan makna bambu dan memberi pemahaman yang komprehensif, penulis menggunakan pendekatan mimetik terhadap sastra Toraja sebagai upaya melahirkan teologi bambu. Teologi bambu dalam konteks ini, hadir sebagai konsep teologi yang mau menceritakan siapa Allah bagi masyarakat Toraja yang secara nyata telah hadir, berkarya, melindungi, dan memelihara melalui ciptaanNya. Teologi bambu lahir dari pemaknaan masyarakat Toraja terhadap arti penting bambu dalam seluruh perjalanan hidup mereka sebagai bagian dari komunitas masyarakat di bumi. Teologi bambu menjadi jembatan untuk melihat seluruh ciptaan Allah (manusia, hewan, dan tumbuh-tumbuhan) sebagai mitra kerja Allah dalam merawat dan melestarikan alam semesta ini.
Manusia sebagai Homo Digitalis
Authors: Taneo Rolin Ferdilianto Sandelgus
Published: July 2024

There is a new term or embedding given to humans when they enter the 21st century, namely Homo Digitalis. This term is reasonable because dependence on technology has become a trend in this era. Humans seem to depend on technology for all aspects of their lives. Technology is good because it makes things easier for people, but if it is not used wisely, the potential for damage exists. Even so, the presence of technology has still really helped humans. The church felt it, too. Theology as a science has the task of discussing this phenomenon. Therefore, this article will utilize literature studies and Public Theology approaches to dissect the issue of Homo Digitalis and throw it into the digital space. Human dislocation in the digital space is a fact, and this is a finding and recommendation for developing other research related to this issue. The ultimate goal of this article is to become an instrument for churches and congregations to respond to technological developments.
Ada istilah atau penyematan baru yang diberikan kepada manusia ketika memasuki abad 21 ini yaitu Homo Digitalis. Istilah ini sebenarnya beralasan sebab di era ini ketergantungan terhadap teknologi sudah merupakan trend. Manusia seperti menggantungkan seluruh aspek kehidupannya kepada teknologi. Hadirnya teknologi sebenarnya baik karena memudahkan manusia tetapi jika tidak secara arif digunakan maka potensi merusak itu ada. Sekalipun demikian, tetap saja kehadiran teknologi sudah amat membantu manusia. Gereja pun turut merasakannya. Teologi sebagai ilmu pengetahuan punya tugas mendiskusikan fenomena ini. Karena itu, tulisan ini akan menggunakan metode studi literatur dan pendekatan teologi publik dalam membedah isu Homo Digitalis dan keterlemparannya di ruang digital. Keterlemparan manusia di ruang digital merupakan fakta yang benar adanya dan ini menjadi temuan dan rekomendasi untuk pengembangan penelitian lain terkait isu ini.  Tujuannya akhir dari tulisan ini yakni menjadi instrumen bagi gereja dan jemaat di dalam menyikapi perkembangan teknologi.
Pengembangan Sistem Informasi Pariwisata Kabupaten Toraja Utara Menggunakan User Centered Design dan WebQual 4.0
Authors: Sangga Harmanto , Dewi Christine , Christanto Henoch Juli
Published: July 2024

Permasalahan yang dihadapi pariwisata Kabupaten Toraja Utara yaitu kurangnya informasi yang memadai mengenai objek wisata, belum adanya sistem yang memberikan informasi pariwisata secara menyeluruh tentang objek wisata, penyebaran informasi masih bergantung pada metode tradisional yakni dari mulut ke mulut sehingga informasi mengenai tempat wisata masih belum tersebar secara luas. Â Untuk mengatasi permasalahan tersebut, diperlukan sistem yang dapat mengelola informasi objek wisata serta menyediakan informasi yang lengkap dan mudah diakses. Penelitian ini mengembangkan sistem informasi pariwisata Kabupaten Toraja Utara menggunakan metode User Centered Design (UCD) dan WebQual 4.0. Salah satu tujuan utama pengembangan sistem informasi pariwisata di Kabupaten Toraja Utara adalah sebagai alat bantu dalam menyampaikan informasi mengenai kawasan wisata yang tersedia di daerah tersebut kepada para wisatawan, dengan tujuan membantu administrasi daerah dalam mengoptimalkan sektor pariwisatanya. Penelitian ini juga bertujuan untuk mengevaluasi sistem informasi pariwisata yang telah di kembangkan menggunakan Webqual 4.0. Dari hasil evaluasi sistem informasi pariwisata menggunakan WebQual 4.0, ditemukan bahwa nilai Usability Quality mencapai 85.60%, Information Quality sebesar 85.24%, dan Interaction Quality sebesar 82.35%, dengan kategori 'Baik' pada setiap variabel. Penilaian tinggi pada Usability Quality menandakan antarmuka sistem memberikan pengalaman pengguna yang baik dan mudah digunakan. Sementara itu, Information Â Â Â Quality yang tinggi menunjukan bahwa informasi yang disajikan dalam sistem mudah dipahami, akurat, dan relevan. Nilai tinggi pada Interaction Quality menandakan bahwa sistem memberikan pengalaman interaksi yang memuaskan bagi pengguna. Dari hasil tersebut dapat diambil kesimpulan bahwa pengembangan Sistem informasi pariwisata di Kabupaten Toraja Utara telah terbukti sebagai alat yang efektif dalam menyampaikan informasi tentang kawasan wisata kepada para wisatawan dan juga membantu administrasi daerah dalam mengoptimalkan sektor pariwisatanya.
PREDIKSI NILAI PENGADAAN BARANG DAN JASA PADA SEBUAH PERUSAHAAN PARIWISATA MENGGUNAKAN METODE ARIMA DAN FUZZY TIME SERIES
Authors: Wati Lisna , Solichin Achmad
Published: July 2024

PT XYZ does not have a tested evaluation metric to measure the accuracy of procurement prediction models. This research aims to find a suitable metric by comparing two methods: Autoregressive Integrated Moving Average (ARIMA) and Fuzzy Time Series (FTS). Both methods were chosen based on the ability of ARIMA to handle time patterns and trends, and the flexibility of FTS in dealing with uncertainty in procurement values. The research uses Root Mean Squared Error (RMSE) values to measure prediction accuracy. The ARIMA implementation analyzes historical data to forecast patterns, while FTS accommodates fluctuations and uncertainties, allowing for more adaptive and accurate predictions. The analysis results show that the ARIMA model has an AIC value of 3953.57 and a residual value of 3351745.26, while FTS has a residual of -224.79. The RMSE evaluation shows the ARIMA value of 3351745.30 and FTS of 224793895.00. The predicted value of ARIMA is 440,326,255, while FTS is 668,471,895. Based on these results, FTS shows superior prediction accuracy compared to ARIMA. FTS is recommended to be implemented at PT XYZ due to its ability to effectively manage uncertainty and fluctuations in procurement values, enabling more accurate strategic decisions. Further research is needed to understand the factors that influence the performance difference between these two methods.
THỰC TRẠNG TỰ HỌC MÔN GIẢI PHẪU CỦA SINH VIÊN TẠI TRƯỜNG ĐẠI HỌC TRÀ VINH
Authors: Vo Khanh Phuong
Published: July 2024

Nghiên cứu xác định tỉ lệ sinh viên có hoạt động tự học môn Giải phẫu và các yếu tố liên quan. Phương pháp nghiên cứu cắt ngang mô tả trên 380 sinh viên tại Trường Đại học Trà Vinh được lựa chọn. Kết quả cho thấy sinh viên đã có nhận thức đúng vấn đề tự học nhưng hành vi tự học môn Giải phẫu của sinh viên chưa cao (70%). Nguồn tài liệu phục vụ cho việc tự học môn Giải phẫu còn thiếu, sinh viên sử dụng chủ yếu bài giảng của Bộ môn cung cấp (66,8%). Hoạt động tự học môn Giải phẫu của sinh viên đạt hiệu quả tốt nhất là sơ đồ hóa nội dung, vẽ hình (47,4%). Những yếu tố ảnh hưởng đến việc tự học của sinh viên là khối lượng kiến thức quá nhiều; chưa có phương pháp, kĩ năng học; áp lực về kiểm tra, thi và ít tài liệu tham khảo. Để nâng cao hiệu quả việc tự học môn Giải phẫu, sinh viên phải biết lập mục tiêu, kế hoạch học hợp lí, có kĩ năng đọc sách và tài liệu tham khảo, tăng cường hoạt động thảo luận nhóm, nói chuyện chuyên đề, đi học đầy đủ, tích cực tham gia xây dựng bài.
KHẢO SÁT KẾT QUẢ TỔNG PHÂN TÍCH NƯỚC TIỂU 10 THÔNG SỐ CỦA SINH VIÊN NĂM NHẤT KHOA Y – DƯỢC, TRƯỜNG ĐẠI HỌC TRÀ VINH
Authors: Trang Thi Hong Nhung , Ngo Anh Duy , Huynh Ngoc Tram
Published: July 2024

Mục tiêu của nghiên cứu là xác định kết quả tổng phân tích nước tiểu 10 thông số của sinh viên năm nhất Khoa Y – Dược, Trường Đại học Trà Vinh. Phương pháp nghiên cứu mô tả hồi cứu trên 573 sinh viên được chọn. Kết quả cho thấy tỉ lệ tổng phân tích nước tiểu 10 thông số bất thường là 37,2%. Trong đó, tỉ lệ bất thường từng thông số là hồng cầu: 17,8%, tỉ trọng: 9,4%, bạch cầu: 8,4%, protein: 5,8%, pH: 3,3%, nitrit: 2,8%, urobilinogen: 2,1%, bilirubin: 1,8%, ketone: 0,9%. Sự khác nhau về giới có ý nghĩa thống kê với xét nghiệm tổng phân tích nước tiểu. Kết quả nghiên cứu góp phần cung cấp dữ liệu về sức khỏe của sinh viên Trường Đại học Trà Vinh, qua đó giúp Nhà trường có kế hoạch nâng cao sức khỏe cho sinh viên, đồng thời tạo cơ sở dữ liệu cho các cuộc khảo sát với quy mô lớn hơn ở các địa phương.
Guru Penggerak and Continuous Professional Development: A Case Study of English Teachers in Palembang
Authors: Retnowati Lusiana Dian , Petrus Ismail , Inderawati Rita
Published: July 2024

The study aimed to determine the significance of Guru Penggerak (GP) in developing the Continuous Professional Development (CPD) of English teachers. This was done by investigating the need for GP among English teachers to enhance their CPD and identifying the components or parts of Guru Penggerak that support their continuous professional development. A qualitative research method was used to investigate the phenomena, with two English teachers who joined Guru Penggerak Batch 1 in Palembang, South Sumatra, Indonesia as participants. Triangulation and member checks were conducted to ensure the dependability of the data obtained from interviews and documentation. The data were described and interpreted using codification, checklists, and thematic analysis. The findings of the study show that it is necessary for teachers of English to join Guru Penggerak to enhance their continuous professional development. After joining the program, English teachers were able to improve three components of their professional development: Self-Development, Scientific Publication, and Innovative Works. It was also found that GP mostly encouraged teachers of English in their pedagogical competencies, but less so in their proficiencies. However, GP provided English teachers with the eagerness to improve their English proficiency individually. Additionally, the study proved that Guru Penggerak (GP) helped advance English teachers’ careers, with some appointed as school principals and assessors of GP in subsequent Batches.
Enhancing Pencak Silat Education through Application-Based Learning Media: A Comparative Study on Teaching Effectiveness and Student Outcomes
Authors: Saputra Iwan , Riza Ade Ros , Faridah Eva , Raswin Raswin , Sunarno Agung
Published: July 2024

This examination is advancement research that expects to configuration learning media that contains appraisals in hand to hand fighting contests, particularly combative techniques and particularly aiding the field of sports science, particularly in the field of refereeing and sports accomplishments in North Sumatra. An application that contains assessments in both legal and illegal pencak silat competitions is the form of the developed media. These assessments are presented in the form of videos and match scoring. Additionally, the application includes a useful assessment of fundamental martial arts and martial arts techniques for use in classes. This thought emerged when specialists wanted to expect to discover that was more viable and proficient, as well as valuable for selecting contender for combative techniques and hand to hand fighting officials. The distribution of training materials for martial arts referees can also benefit from this application, particularly in the field of refereeing. The information displayed in this study is a correlation of the viability of the learning model for every mark of the evaluation of the new learning model (in the wake of utilizing the application) more successful than the old learning model (prior to utilizing the application). The new learning model has an efficiency of 85.71 percent, while the old learning model has an efficiency of 60 percent. The old learning model's average effectiveness of implementation indicators was 50%, while the new model's average effectiveness was 70%. Therefore, it can be concluded that the new learning model is superior to the old learning model (previous to using a drill machine) after using a drill machine.
Investigating the Influence of Hybrid and Independent Learning on Student Learning Outcomes in European History Courses
Authors: Harahap Hanif , Anis Madhan , Ramazan Ramazan , Sahudra Tengku Muhammad
Published: July 2024

The importance of implementing a hybrid learning model that combines face-to-face teaching with online computer-assisted teaching to create an integrated learning approach and student learning independence. The purpose of this study was to analyze the effect of hybrid and independent learning on student learning outcomes in European History courses. This study adopts a quantitative method and a quasi-experimental design. In collecting data the researchers used multiple-choice test techniques and questionnaires to examine students’ learning independence. The data analysis technique used is the Two-way ANOVA statistical test. The results of the study showed that there was an increase in student history learning outcomes for European history courses with "moderate" criteria with a score of 0.54 (0.3 N-Gain ≤0.7) after the implementation of hybrid learning. Hybrid learning has an effect on student learning outcomes in history education with a sig model value of 0.002, where the value is less than 0.05 (0.002 0.05). Independent learning has an impact on student learning outcomes with a sig questionnaire value of 0.042 where the value is less than 0.05 (0.042 0.05). In conclusion, in European history courses offered the learning model and learning independence has an impact on students' learning outcomes.