bluuebunny/crossref_metadata_2025 huggingface dataset:
CARBON SEQUESTRATION IN THE OCEAN-AN ESCAPE ROUTE
Authors:   Nigerian Institute of Leather and Science Technology, Onyemachi David Ibeabuchi , Eze Wilson Uzochukwu ,   Nigerian Institute of Leather and Science Technology, Musa Mekidani  Aaron ,   Nigerian Institute of Leather and Science Technology, Okolo Virginia Ngozi ,   Nnamdi Azikiwe University, Kalip Amos Dindul ,   National Space Research and Development Agency, Paulleo Pascalina ,   Nigerian Institute of Leather and Science Technology, Igiri Bernard Egwu ,   Nigerian Institute of Leather and Science Technology, John Abba ,   Nigerian Institute of Leather and Science Technology
Published: March 2022

The utilization of fossil fuels is releasing previously carbon stored in the various carbon pools of the earth and increasing the global concentration of Carbon dioxide from an initial 280 parts per million in the 1850s to above 400 parts per million today. This review takes a look at previous works on carbon sequestration; its feasibility, potential and process. Increased carbon emission has disrupted the fragile balance in carbon content between the atmosphere and ocean which took thousands of years to attain. Aftermath of which includes increase global temperatures as well as other environmental problems. It has been projected that from 2025 up-wards; we would have exceeded our carbon budget at our current emission rates. Curtailing fossil fuel utilization alone will not suffice to save the planet unless something more drastic is done. Capturing anthropogenically produced carbon gas and discharging it into the ocean at a depth of 3000m where it sinks into the bottom of the ocean is recommended. Here, the oceans are expected to store about 59 times the carbon gas carrying capacity of the atmosphere. The need to speed up the slow natural process of sequestrating carbon in the ocean depth has never been more expedient. Research is recommended into understanding the oceans as a variegated system of interactions compared to terrestrial ecosystems.
APPLICATION OF FORMALIZED MODELS OF EVENTS FOR EVALUATION OF DANGER AND ACCIDENT ASSESSMENT OF THE COMPRESSOR STATION OF THE MAIN PIPELINE
Authors:   Lviv State University of Life Safety, Babadzhanova Olga , Vasiichuk Viktor ,   Lviv Polytechnic National University, Charlak Michał ,   Lublin University of Technology
Published: March 2022

An effective approach to solving the problem of reducing man-made hazards is the use of specialized systems for forecasting and minimizing risks. The theoretical basis for hazard assessment is probabilistic safety analysis (IAB). The most common method of assessing the danger and accident is the development of formalized models of events is the use of logical-probabilistic models "failure tree" (FTA) and "event tree" (ETA). These methods are widely used in the world to analyze the risk of accidents at facilities with increased levels of danger. They are used both for the preliminary analysis of safety during the development of recommendations for reducing the level of risk and for investigating the causes of accidents at hazardous facilities. In Ukraine, such methods are used in the development of safety declarations for high-risk facilities. Considering a great number of hazards inherent in the operation of main pipelines, it is important to understand which of these risks are most critical. The specifics of their operation is directly related to the risk of cascading accidents. The purpose of the work is to establish criteria and assess the danger of accidents at the compressor station of the main gas pipeline.
CASTLES OF UKRAINE IN THE WORKS OF THE 19TH CENTURY ARTISTS
Authors: Gavryliv Кalyna-Theodora
Published: March 2022

Castles and their ruins are precisely the types of structures that attracted the attention of 19th century artists due to their romantic image. Artists, according to the specifics of their work, pay attention to various artistic and stylistic aspects: panoramic views, silhouette, details. The work orients the viewer to the location of the castle in the architectural and landscape environment, provides a holistic perception of the castle in space, dictates the silhouette of the structure, fixing its view from the corresponding side, reflects the colour of the object. Achromatic images convey the perception of the tonal saturation of the object and the environment, chromatic images - watercolors, oils - indicate the color scheme. It is important that the artists conveyed the emotions that the environment, objects, nature evoked in them. Each artist chose their angle and time of day to admire what he saw, which he wanted to share with others through his works. To a number of artists, who reflected in their works castles located on the territory of Ukraine, we refer Antoni Lange, Emanuel Kratochwille von Kronbach, John Henry Muntz, Karl Auer, Maciej Bogusz Zygmunt Stęczyński, Napoleon Orda. Based on the works of Napoleon Orda, we can conclude that the percentage of preserved existing stone castles is 16%, partially preserved and partially restored castles - 9%, castles that are in disrepair and are subject to complete restoration - 16%, castles in ruins, the condition of which has significantly deteriorated over the past two centuries, and whose fragments can be preserved in a state of long-term ruin - 53%, and irretrievably lost - 6%. Drawings, lithographs, engravings, watercolors and oils - today serve as an iconographic source for scientific reproductions of the type of monuments for the corresponding period of their existence. Artistic works should not be considered as the only correct source for graphic reconstructions or restoration interventions in architectural monuments, but they are an integral part of a number of historical sources from which we draw information about the type of the object and its environment for the corresponding period of time. From them we learn about the state of the structure, its silhouette, details and colours, the composition of the architectural and landscape environment, its landscaping and picturesqueness.
RESEARCH ON THE TRINITY MONASTERY OF THE STANISLAWOW FORTRES
Authors: Serbin Anna
Published: March 2022

The Trinitarian monastery and church was an important part of the original planning structure of the Stanislawow fortress city (now Ivano-Frankivsk), an architectural complex of ground and underground buildings with a religious, residential and warehouse purpose. The research identifies the original form and composition, historical building periods, further development and current state of the monastic complex of the Trinitarians. Dozens of historians, architects, local history explorers have left their essays or articles about this complex. However, the church itself was not examined, as it was destroyed in the 19th century. Using the method of analogies, the architect Zenoviy Sokolovsky has recently made a graphic reconstruction of the facade of the Trinitarian church and monastery. The author took as a basis the facades of Trinitarian monastery in Kamianets-Podilskyi and Lutsk. Due to the usage of the analogies method, this work should be treated with caution, as it is not confirmed by any real iconographic source. This thesis is confirmed by the source we found. The study was conducted to determine the original appearance of the Trinitarian church and monastery in Stanislawow, its construction periods, planning structure and state of preservation.
PARADIGMA PEMBELAJARAN EFEKTIF BAHASA DAN SASTRA INDONESIA
Authors: Wahyuni Febri , Herlinda Herlinda
Published: March 2022

Paradigma pembelajaran bahasa dan sastra Indonesia merupakan literasi budaya. Pembelajaran bahasa dan sastra Indonesia secara formal dimulai ketika memasuki sekolah dasar hingga sekolah menengah atas. Secara keseluruhan formal masing-masing anak mendapatkan pembelajaran bahasa dan sastra Indonesia selama 12 tahun. Tujuan pembelajaran bahasa dan sastra Indonesia agar peserta didik memiliki kemampuan menggunakan bahasa Indonesia yang baik dan benar untuk meningkatkan kemampuan intelektual, dan dapat menghargai serta membanggakan bahasa Indonesia sebagai bahasa persatuan dan bahasa negara. Pembelajaran bahasa dan sastra Indonesia dapat efektif apabila mencapai tujuan pembelajaran yang diinginkan sesuai dengan indikator pencapaian. Guru sebagai pembimbing diharapkan mampu menciptakan kondisi dan suasana yang strategi yang dapat membuat peserta didik nyaman dalam mengikuti pembelajaran. Untuk meningkatkan cara belajar bahasa dan sastra Indonesia yang efektif diperlukan strategi yang tepat agar pembelajaran dapat berjalan dengan optimal dan efektif.
PENINGKATAN MENULIS KARYA ILMIAH MELALUI MODEL PEMBELAJARAN DIRECT LEARNING
Authors: Sardila Vera , Murny Murny , Rahayu Ariyanti
Published: March 2022

Bahasa merupakan suatu keterampilan yang meliputi aspek membaca, menulis, berbicara, dan menyimak. Keempat aspek ini saling berkaitan satu sama lain dan perlu dikembangkan guna menyampaikan gagasan yang terkandung dalam pikiran. Dengan demikian dapat diartikan bahwa menulis juga sekaligus keterampilan yang perlu dikembangkan mengingat sangat pentingnya aktivitas ini dalam kehidupan kita yang tidak hanya sebagai kewajiban namun juga merupakan kebutuhan. Dengan demikian diperoleh hasil penelitian bahwa menulis karya ilmiah dengan menggunakan model pembelajaran Direct Learning yaitu pembelajaran secara langsung dapat meningkatkan kemampuan menulis karya ilmiah mahasiswa, hal ini tergambar dari tingkat persentase mengalami kenaikan yakni dari data awal hasil kemampuan menulis karya ilmiah mahasiswa Pendidikan Bahasa Indonesia tergolong pada kategori kurang (38%) hingga akhirnya mengalami kenaikan dengan menggunakan model pembelajaran Direct Learning mencakap pada kategori Baik (33 %). Dengan demikian dapat disimpulkan bahwa kemampuan menulis karya ilmiah mahasiswa Pendidikan Bahasa Indonesia dapat ditingkatkan dengan menggunakan model pembelajaran Direct Learnig.
DEIKSIS PERSONA DALAM ACARA MATA NAJWA EPISODE “VAKSIN SIAPA TAKUT?”
Authors: Defrilyana Maya , Sinaga Mangatur , Septyanti Elvrin
Published: March 2022

Tujuan penelitian ini adalah (1) Mendeskripsikan jenis deiksis persona dalam acara Mata Najwa episode “Vaksin Siapa Takut?” (2) Memapaparkan referensi deiksis persona dalam acara Mata Najwa episode “Vaksin Siapa Takut?”. Jenis Penelitian ini adalah penelitian kualitatif. Metode yang digunakan adalah metode deskriptif. Jenis deiksis persona yang ditemukan ada lima jenis yaitu; deiksis persona pertama tunggal, deiksis persona pertama jamak, deiksis persona kedua tunggal, deiksis persona ketiga tunggal, dan deiksis persona ketiga jamak. Referensi deiksis persona yang ditemukan yaitu; deiksis persona eksofora, dan deiksis persona endofora.
Electric Power Distribution System Overvoltage Protection Devices
Authors:   FSUE ", SHVETS Nikolay N. ,   RFNC-VNIITF named after Academ. E.I. Zababakhin", LEPEKHIN Nikolay M. ,   FSUE "RFNC-VNIITF named after Academ. E.I. Zababakhin", MIROSHNICHENKO Valery P. ,   FSUE "RFNC-VNIITF named after Academ. E.I. Zababakhin", ORLOV Alexander I. ,   FSUE "RFNC-VNIITF named after Academ. E.I. Zababakhin", SYSOEV Vladimir S. ,   FSUE "RFNC-VNIITF named after Academ. E.I. Zababakhin", DUBOV Igor V. ,   FSUE "RFNC-VNIITF named after Academ. E.I. Zababakhin", BASOV Evgeniy V. ,   All-Russian Electrotechnical Institute – Branch of FSUE "RFNC-VNIITF named after Academ. E.I. Zababakhin"
Published: March 2022

Surge protection devices of limiting and combined types used in 0.4 kV electric power distribution networks are described, and results of their experimental studies are presented. The devices have been developed in four earthquake-resistant designs with the use of new-generation nonlinear resistors (varistors) and controlled vacuum arresters. The developed protective devices are intended to limit transient overvoltages, which occur under the influence of man-made, natural and switching electromagnetic pulses, to a safe level, which for the developed design versions of protective devices lies in the range from 1.5 kV to 4.0 kV, and to remove pulses of high-energy currents (up to 500 kJ in a pulse). The article presents the results from studies of the switching characteristics of the developed protective devices in their nominal (multiple) and maximum (single) operation modes, with the measurement of limit voltages at their terminals. The practical effectiveness of using the combined type protective devices is estimated, and the performance characteristics of protection devices from different manufacturers are given.
A Brushless Adjustable Excitation Generator
Authors:   Northern (Arctic) Federal University named after M.V. Lomonosov, KOPTYAEV Evgeniy N. , IVLEV Mark L. ,   Northern (Arctic) Federal University named after M.V. Lomonosov
Published: March 2022

Wind turbines are further developed toward improving their reliability and efficiency, and reducing maintenance costs during long-term operation. For this purpose, synchronous generators with excitation from permanent magnets are used, the parameters of which determine in many respects the efficiency and dimensions of the power plant as a whole. The article proposes a new design of a brushless synchronous generator with excitation longitudinal with respect to the rotor rotation axis. The generator features a simple design of its rotor poles and double frequency of the secondary winding voltage. The possibility of manufacturing the stator housing from cheap plastic or similar non-magnetic materials is noted, due to which a reduction in the generator mass and cost can be achieved; such generator can find use mainly in small and medium capacity power plants. To close the rotor excitation magnetic flux, longitudinal magnetic cores with coils on them are installed in the slots of the non-magnetic stator housing. This makes it possible to improve heat removal from the secondary winding and simplify the assembly. Smooth adjustment of the output voltage in a wide range of rotation speeds is possible. The results of modeling the magnetic field in the air gap between the stator and rotor and the output voltage waveform for the basic magnetic system configuration are presented.
Perbandingan Transfer Panas Pada Software Psi-Therm, HTflux Dan Ansys
Authors: Paulus Dimitri Ryumiliano , Purwanto LMF
Published: March 2022

Dalam mendesain suatu bangunan tentunya harus memperhatikan kondisi iklim setempat untuk mencapai kenyamanan pengguna dalam melakukan aktivitas. Pada iklim tropis yang memiliki suhu lingkungan yang cukup tinggi tentunya akan mempengaruhi kondisi interior ruangan. Proses perambatan panas ini diminimalisir dengan menggunakan AC, pemilihan material dinding dan perencanaan dinding melalui software. Namun penggunaan AC yang berlebihan di dalam ruangan akan membuat konsumsi listrik menjadi tinggi dan berdampak pada penambahan panas pada bangunan. Pada penelitian ini digunakan software Psi-therm, HTflux dan Ansys untuk mensimulasikan perpindahan panas matahari ke dalam gedung. Tujuan utama penggunaan perangkat lunak adalah untuk menentukan aliran perpindahan panas ke struktur bangunan dan meminimalkan perpindahan panas melalui penggunaan bahan peredam pada dinding. Selain itu untuk mengetahui perbedaan hasil analisis dari ketiga software tersebut. Metode penelitian ini adalah deskriptif kuantitatif dengan mengumpulkan data di lapangan yang berhubungan dengan suhu di luar dan di dalam bangunan serta material penutup dinding. Data yang terkumpul akan dimasukkan ke dalam software Psi-Therm, HTflux, dan Ansys untuk menganalisis distribusi panas matahari pada struktur bangunan. Dengan menggunakan gambar sebaran panas yang telah dianalisa oleh perangkat lunak maka dilakukan upaya untuk meminimalisir panas tersebut dengan menggunakan bahan peredam pada dinding bangunan.
MODERN APPROACH OF ARTISTIC AND PERSUASIVE MARKETING COMMUNICATION
Authors: ROȘCA Mihai-Ioan , MADAN Angela
Published: March 2022

Persuasion sparks interest among the general public and marketers. Persuasive strategies activate discourses on responsible and sustainable business. This is an interesting phenomenon that needs to be studied, explained, and understood in order to destroy the myth among consumers. The purpose of this paper is to explore influence techniques used in marketing communication in order to test and develop a theoretical approach of art implication as a persuasive tool. This article, based on a secondary source case study, is reviewing the influence of art on consumer behavior. Related results from persuasive literature and survey results, based on 689 respondents, mainly from Romania, indicate that persuasive power has an impact according to the style of communication. Some advertisements try to increase persuasiveness, as a company’s marketing communication needs to appeal to ethics and morality. Art represents “one of the world’s most sacred cultural resources”. Different categories of artwork are mentioned, as well as their degree of cultural recognition. Art and persuasion are also the main principles for luxury retailers. After a conceptual framework, we developed a study that embraced art and science. Studying art as an influence technique represents interest among marketers, as a notoriety topic, not enough studied. The implications and findings of this research suggest that persuasive techniques based on art require continued research. This paper helps to place this subject in a proper perspective and clarifies much of its confusion. The results advance specialty theory and provide insights for marketers.
JEL Classification: M31, M37, M39
THE INFLUENCE OF ORGANIZATIONAL CULTURE IN STRATEGIC TRANSFORMATION THROUGH MERGERS AND ACQUISITIONS CASE STUDY: FOOD INDUSTRY IN ROMANIA
Authors: PIPER Cristina Ioana
Published: March 2022

The business environment is a living organism that is continuously moving and evolving. To perform in this dynamic environment, companies need to increase existing resources, including through mergers and acquisitions. Mergers and acquisitions in Romania have had significant growth in recent years, and among the most dynamic sectors of the economy is the food industry. During the pandemic, according to Global Data, M&A in the Food Sector dropped 38%, however, it is expected that the trend will increase in the next few years. The experience proves that, despite their popularity, many mergers and acquisitions are not successful because they anticipate synergies that are not fulfilled. In addition to strategic fit, there is a strong relationship between the success of an organizational transformation and the organizational culture. The present study tries to identify the mechanism that ensures the success of the transformation process through mergers and acquisitions. The research aims to identify the models and mechanisms that ensure the success of the transformation process, from an organizational culture perspective. Finally, summarizing the results of this research, we could suggest helpful interventions in the organization going through mergers and acquisitions. In this way, businesses can limit the negative effect of the transformation processed and improve their chances of performance.
JEL Classification: G34, L2
Sindicalismo y género: un balance posible
Authors: Andújar Andrea
Published: March 2022

Este dosier reúne cuatro estudios interesados en la historia reciente de las trabajadoras en la Argentina. El texto introductorio enmarca tales trabajos tomando como punto de partida la ampliación notoria de este campo historiográfico en los últimos años. A tal fin, ofrece un conjunto de argumentos sobre ese crecimiento a la luz de la masividad ganada por el movimiento feminista, la difusión e influencia creciente experimentada por la historia social de la clase trabajadora en perspectiva de género en el mundo académico y la presencia cada vez mayor del activismo feminista dentro de los sindicatos.
“Nosotras queríamos justicia, pero también tener clases y seguir viendo a nuestras amigas…”. Resistencias de feministas universitarias en Chiapas, México
Authors: Ruiz Coutiño María Guadalupe
Published: March 2022

Esta es una conversación con la Red de Colectivas Feministas Universitarias de Chiapas (RECOFUCH) y dialoga sobre la organización política de mujeres jóvenes universitarias que la integran. El rango de edad de las entrevistadas es entre 16 y 22 años. La red es conformada por colectivas formadas en facultades de la Universidad Autónoma de Chiapas (UNACH) y otras universidades en el estado de Chiapas al sureste mexicano.
Paula Alcaide (2019). Cómo superar un bollodrama. Navarra: Egales, 285 págs.
Authors: Andriola Karina Alejandra
Published: March 2022

Revisión del libro Cómo superar un bollodrama por P. Alcaide
Lecturas insumisas. Algunos aportes a partir de Javier Gasparri (2017). Néstor Perlongher: por una política sexual. Rosario: FHUMYAR Ediciones.
Authors: Cocciarini Natalia
Published: March 2022

Revisión del libro Néstor Perlongher: por una política sexual por J. Gasparri
Escenas de teatro en road-movies de ambientación medieval
Authors: García-Manso Angélica
Published: March 2022

La inserción de escenas teatrales en tramas fílmicas posee en líneas generales un carácter programático, más evidente si cabe en el género de las road-movies. Se analiza la escena teatral que aparece en la película Paseo por el amor y la muerte (1969), de John Huston, cuyo sentido cinematográfico viene reforzado por el hecho de que no aparece en la novela que inspira el filme. Se estudian los recursos de tramoya y la caracterización de personajes, como escenografía e indumentarias singulares a pesar de la excepcionalidad de la escena. A partir del análisis se comprueba cómo la representación escénica incumple en buena medida las pautas del teatro medieval incluso en sus momentos avanzados, al potenciar la simbología laica sobre la religiosa, al basarse irónicamente en un relato basado en cuentos infantiles en lugar de un imaginario alegórico y, finalmente, al proceder a la hibridación de temas medievales con iconos de la Revolución Francesa y temas de la literatura norteamericana posteriores. Dicha antítesis refuerza, por contraste, la comprensión del teatro de Edad Media avanzada.
EL lazareto de Oza (A coruña)
Authors: Teijeiro Mosquera Daniel Lucas
Published: March 2022

El lazareto de Oza fue un complejo hospitalario marítimo erigido en el antiguo castillo de Oza, situado en una situación privilegiada de resguardo en la bahía de A Coruña (Galicia, España). Estando activo entre 1889 y 1903, su función se destinó a la observación y tratamiento de las personas y mercancías que llegaban al puerto herculino en los buques siendo sospechosas o estando infectadas principalmente por cólera morbo asiático, fiebre amarilla o peste levantina. No obstante, su construcción estuvo condicionada por el impacto de las transformaciones sociales, políticas y económicas que vivió la población coruñesa a causa de las epidemias interoceánicas.

Si bien existen algunas publicaciones que se centraron en la historia sanitaria, corporativa y administrativa de este lazareto ya desaparecido, con este artículo se presta atención por primera vez en la memoria de su arquitectura desaparecida, sirviendo así como caso de estudio paradigmático para la historia de la arquitectura hospitalaria. La necesidad de esta línea de investigación se debe al desconocimiento de la fisionomía y organización arquitectónica que poseía, por lo que se muestran como documentos inéditos algunos de sus planos conservados junto con otra documentación gráfica.
El rostro ajeno
Authors: Santos Antonio
Published: March 2022

El rostro ajeno (Tanin no kao), película de Hiroshi Teshigahara (1966) con guión de Kôbô Abe a partir de su novela (1964), propone una rigurosa especulación sociológica y filosófica sobre lo anómalo, lo monstruoso y sobre la pérdida de identidad.  El presente trabajo se centrará en el comentario específico de tres breves escenas en las que se confrontan las perspectivas del deformado protagonista y su esposa entre  dos referentes artísticos muy distantes: la Minotauromaquia de Pablo Picasso, y la ancestral cerámica Jômon, que se sitúa en los orígenes mismos de la historia y la cultura japonesas. Aquel emblemático aguafuerte, obra fundamental del artista malagueño (1935), se reconoce en los episodios que definen la crisis del matrimonio dentro del entorno doméstico. Su presencia, además de ilustrar el desencuentro emocional, genera un sofisticado recurso metalingüístico, al dar forma a una subtrama ajena al argumento principal, al que complementa y confiere un nuevo sentido. El hogar de los Okuyama se reconoce, a partir del contraste entre obras artísticas muy diferenciadas, como un espacio de muerte, de impostura y de extravío: una tumba doméstica y un laberinto existencial. Pero aún es posible reconocer otras cuestiones de calado; en el curso de la escena, el arte moderno se confronta y dialoga con el arte primitivo. La minotauromaquia y la cerámica prehistórica establecen un vínculo cerrado entre el principio y el fin del arte, ilustrando el retorno a los orígenes como vía de renovación artística. Del mismo modo que Picasso acude a los mitos primordiales y a las culturas ancestrales para dar nuevo impulso a su arte, Teshigahara reivindica las raíces culturales e históricas del pueblo japonés como fuente original.
Los catálogos del patrimonio inmueble en Málaga
Authors: Santana Guzmán Antonio Jesús
Published: March 2022

El patrimonio inmueble de Málaga ha sido una de las líneas de investigación del profesor Francisco García Gómez. A través de las publicaciones que dedicó a este campo, se presenta aquí una revisión personal sobre algunos ejemplos de actuaciones positivas y negativas bajo su criterio, a la par que se expone la situación actual en la que se encuentra la legislación encargada de salvaguardar la arquitectura y el urbanismo local, así como de los diferentes catálogos que los recoge. Se recuerda además la necesidad de su actualización debido al peligro que supone su estatismo para este tipo de bienes culturales.
Eosinophil-derived neurotoxin: An asthma exacerbation biomarker in children
Authors: Kim Hwan Soo , Yang Hyeon-Jong , Song Dae Jin , Lee Yong Ju , Suh Dong In , Shim Jung Yeon , Yoo Young , Kim Chang Keun , Ahn Young Min , Kim Jin Tack
Published: March 2022

Background: Asthma is a heterogeneous disease, characterized by chronic airway inflammation. Asthma exacerbations (AE) are episodes characterized by a progressive increase in symptoms of shortness of breath, cough, wheezing, or chest tightness with a decrease in lung function.
There have been previous studies that examined the role of eosinophil-derived neurotoxin (EDN) in asthma, but there have been no studies of the role of EDN in children experiencing AE. Objective: In this study, we aimed to examine the association of EDN with lung function
and prognosis in children admitted for severe AE. Methods: We enrolled 82 children who were admitted for severe AE at two different university hospitals in South Korea between January 2018 and December 2019. Blood tests, including white blood cell count, myeloperoxidase
(MPO), total eosinophil count, EDN, C-reactive protein (CRP) level, and interleukin (IL) 4, IL-5, IL-10 values, and lung function were measured on admission and at discharge in each patient. Results: We observed significant decreases in the levels of MPO, EDN, CRP, and
IL-4, with significant improvement in lung function after treatment. We then classified the subjects into two groups of different clinical phenotypes: eosinophilic asthma exacerbation (EAE) group and non-EAE group. EDN levels were higher and lung functions were lower in the EAE group. Also,
we found that the EDN level was a significant biomarker useful for predicting the number of days for hospital stay. Conclusion: We found that EDN can act as a biomarker that reflects lung function, and that EDN could act as a prognostic biomarker, which demonstrated the
complex role of EDN in children experiencing AE.
TANGGUNG JAWAB PENGELOLA JALAN TOL ATAS KECELAKAAN DI JALAN TOL JAKARTA-CIKAMPEK
Authors: Ariswari Khosyi Putra , Nurbaiti Siti
Published: March 2022

Jalan Tol merupakan jalan bebas hambatan, akan tetapi masih banyak pengguna jalan yang merasa tidak aman, seperti kasus pecahnya ban mobil pada KM 39+500 di Jalan Tol Jakarta-Cikampek. Bagaimana Tanggung Jawab Pengelola Jalan Tol Jakarta-Cikampek pada kecelakaan yang terjadi di KM 39 Tol Cikampek menurut Undang- Undang No. 38 Tahun 2004 Tentang Jalan dan bagaimana pemberian ganti rugi oleh Pengelola Jalan Tol Jakarta-Cikampek terhadap korban kecelakaan di KM 39 Jalan Tol Jakarta-Cikampek, merupakan pokok permasalahan yang dibahas. Metode penelitian yang dipergunakan merupakan penelitan normatif, bersifat deskriptif, dengan bersumber pada data sekunder dan data primer sebagai data pendukung. Analisis dilakukan secara kualitatif dengan penarikan kesimpulan secara deduktif. Hasil penelitian menggambarkan bahwa pengelola jalan tol Jakarta-cikampek tidak bertanggung jawab sesuai dengan ketentuan Pasal 42 UU 38 Tahun 2004 Tentang Jalan, dan pemberian ganti rugi yang diberikan oleh pengelola jalan tol Jakarta-cikampek terhadap korban hanya sebatas kerugian materil saja, tidak mencakup kerugian immateril. PT (Persero) Jasa Marga Dianggap Lalai Karena Terbukti Masih Ada Ruas Jalan Yang Tidak Memenuhi Standar Pelayanan Minimal Jalan Tol.
A Training Game for Students Considering Family Medicine: an Educational Project Report
Authors: Van Rossem Inès ,   Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel, Brussels, Belgium, Devroey Dirk ,   Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel, Brussels, Belgium,   Dirk Devroey, Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium, Phone: +32 2 477.43.11, Fax: +32 2 477.43.01, E-mail: dirk.devroey@vub.be, De Paepe Kristien ,   Department of Pharmaceutical Sciences, Vrije Universiteit Brussel, Brussels, Belgium, Puttemans Francis ,   Department of Pharmaceutical Sciences, Vrije Universiteit Brussel, Brussels, Belgium, Petit Pascale ,   Study Guidance Centre, Vrije Universiteit Brussel, Brussels, Belgium,, Schol Sandrina ,   Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel, Brussels, Belgium, Deridder Sander ,   Department of Chemical Engineering, Vrije Universiteit Brussel, Brussels, Belgium, Vandevoorde Jan ,   Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel, Brussels, Belgium
Published: March 2022

The Groningen Institute Model for Management in Care Services aims to prepare medical students for their complex tasks as family physicians, based on the CanMEDS framework. Although initially developed for pharmacy students, the present paper reports on the eight-year experience with GIMMICS for family physician students at the Vrije Universiteit Brussel.

The Groningen Institute Model for Management in Care Services is a training game that simulates real-life situations in a structured and supervised setting. It offers students the possibility to practice clinical, practical, and communicational skills. Students install and manage their group practices, hold consultations with simulated patients, participate in several assignments and collaborate with pharmacy students. Feedback sessions showed that the training game is well-received by the students. A self-assessment questionnaire comprised of 23 questions on significant aspects of the seven CanMEDS roles showed significantly higher scores at the end of the game for 17 questions (p<0.05, Wilcoxon signed-rank test ).

GIMMICS is a valuable linking pin between the different learning methods in medical education and clinical practice, helping students to improve themselves in the CanMEDS roles. However, simulation-based medical education requires significant time and resource investment.
Russian Germans as an Ethno-Linguistic Community: Historical Development and Current State of the Youth Group in Moscow
Authors: Riazantseva D. S. , Bergelson M. B.
Published: March 2022

From the end of September 2020 to November 2021, the Year of Germany was held in the Russian Federation. At present, while summing up its results, it seems only relevant to do some work on the study of the multifaceted ethnolinguistic community of Russian Germans, especially its Moscow diaspora. In this article, two key points are considered: the history of representatives of the community to the present day and the empirical part of the study that analyzes indepth interviews of respondents from among young Russian Germans under the age of 35, living in Moscow. The main purpose of the work was to find out what state this ethno-linguistic community is in today: to consider the problem of self-identification of its members, to trace their native language level and interest in studying and preserving the cultural heritage of their ancestors. The study of various sources has shown that throughout the history of the life of Germans in our country, the attitude towards them has repeatedly changed: from positive to hostile, to more neutral; from praising this community as that of competent specialists and innovators in many fields to persecution and repression during the first half of the twentieth century, and, eventually, refusal to be recognized as a full-fledged community. As a result of these actions on the part of the Soviet government, the community of Russian Germans found themselves in a state of identity crisis facing the problem of the gradual disappearance of their linguistic and cultural landscape. Interestingly, the interviews compiled on the basis of a form created within the framework of the “Languages of Moscow” project helped to find out that in Moscow, historically one of the most important centers of initial settlement of Germans in Russia, their community is not visible any more due to the low level of presence of native Moscow Germans. At the same time, there is a chance for its growth since many respondents consider it to be important to pass on their rich cultural and linguistic heritage to their descendants and continue to develop it on the territory of Russia. So, we believe that the current work has a potential for further and deeper research of the ethno-linguistic community, in particular with the focus on the diaspora of Russian Germans who emigrated to Germany (namely rusacks).
The Problem of Overextension: Analyzing America’s Black Sea Policies through Jentleson’s 4 Ps Framework
Authors: Ülgül Murat , Köse İsmail
Published: March 2022

Historically, the U.S. strategy in the Black Sea region has been stable, limited, and not ambitious as American administrations prioritized certain foreign policy objectives over other interests. This careful strategy was transformed during the Clinton Administration in the mid-1990s as the U.S. started following an extensive foreign policy framework, which included all American national interests, formulated by Bruce Jentleson in his 4Ps framework: power, peace, prosperity, and principles. The article argues that this transformation was problematic because of two obstacles –the illusion of the unipolar moment and the growing polarization in American domestic politics– which prevented the U.S. from following an effective policy in the Black Sea region.
The New German Coalition and Its Impact on EU-Turkey Relations
Authors: Meşe Zafer
Published: March 2022

Turkish-German relations not only have a long tradition of close cooperation but are also based on mutual dependence. A structure that has become increasingly complex and intertwined over time shapes the dynamics of Turkish-German relations through numerous historical, economic, cultural, and social factors. As a result, the scale of the bilateral relationship has occasionally caused frustration and disappointment due to various political differences on both sides. The growing European dimension of bilateral relations has further complicated relations and is increasingly dominating the agenda. Since the turn of the millennium, Turkish-German relations can be described as a roller coaster ride. There have been many ups and downs, conflicts, and collaborations. In the past, the formation of a new government in Germany with a new Federal Chancellor (Gerhard Schröder, Angela Merkel) had a decisive influence on the course of the roller coaster ride. It is therefore necessary to analyze the possible effects of the new federal government under Chancellor Olaf Scholz on bilateral relations with a concentrated focus on European politics.
Acinic Cell Carcinoma of Buccal Mucosa Masquerading as Infratemporal Fossa Tumour: A Rare Case Report
Authors: Dwivedi Gunjan , Gujrathi Sagar , Sood Amit
Published: March 2022

Acinic cell carcinoma (ACC) is a malignant epithelial salivary gland tumour. ACC commonly affects the parotid gland in 90% of cases. ACC rarely affects the minor salivary glands, but once affected it shows a less aggressive course. The purpose of this report is to present a rare case of ACC on minor salivary gland with an unusual presentation in an Indian male patient who was treated in our hospital.
The Path to Actinorhodin: Regio- and Stereoselective Ketone Reduction by a Type II Polyketide Ketoreductase Revealed in Atomistic Detail
Authors: Serapian Stefano Artin , Crosby John , Crump Matthew P. , van der Kamp Marc W.
Published: March 2022

In type II polyketide synthases (PKSs), which typically biosynthesize several antibiotic and antitumor compounds, the substrate is a growing polyketide chain, shuttled between individual PKS enzymes whilst covalently tethered to an acyl carrier protein (ACP): this requires the ACP interacting with a series of different enzymes in succession. During biosynthesis of the antibiotic actinorhodin, produced by Streptomyces coelicolor, one such key binding event is between an ACP carrying a 16-carbon octaketide chain (actACP) and a ketoreductase (actKR). Once the octaketide is bound inside actKR, it is likely cyclized between C7 and C12 and regioselective reduction of the ketone at C9 occurs: how these elegant chemical and conformational changes are controlled is not yet known. Here, we perform protein-protein docking, protein NMR, and extensive molecular dynamics simulations to reveal a probable mode of association between actACP and actKR; we obtain and analyze a detailed model of the C7-C12-cyclized octaketide within the actKR active site; and confirm this model through multiscale (QM/MM) reaction simulations of the key ketoreduction step. Molecular dynamics simulations show that the most thermodynamically stable cyclized octaketide isomer (7R,12R) also gives rise to the most reaction competent conformations for ketoreduction. Subsequent reaction simulations show that ketoreduction is stereoselective as well as regioselective, resulting in an S-alcohol. Our simulations further indicate several conserved residues that may be involved in selectivity of C7-12 cyclization and C9 ketoreduction. Detailed insights obtained on ACP-based substrate presentation in type II PKSs can help design ACP-ketoreductase systems with altered regio- or stereoselectivity.
Towards High Temperature Light-Induced Spin State Trapping in Spin Crossover materials: the Interplay of Collective and Molecular Effects
Authors: Nadeem Muhammad , Cruddas Jace , Ruzzi Gian , Powell Ben
Published: March 2022

Spin crossover (SCO) materials display many fascinating behaviors including collective phase transitions and spin-state switching controlled by external stimuli, e.g., light and electrical currents. As single molecule switches, they have been feted for numerous practical applications, but these remain largely unrealized – partly because of the difficulty of switching these materials at high temperatures. Here we introduce a semi-empirical microscopic model of SCO materials combining crystal field theory with elastic intermolecular interactions. We show that, for realistic parameters, this model reproduces the key experimental results including thermally induced phase transitions, light-induced spin-state trapping (LIESST), and reverse-LIESST. Notably, our model reproduces and explains the experimentally observed relationship between the critical temperature of the thermal transition, T1/2 , and the highest temperature for which the trapped state is stable, TLIESST. We propose strategies to design SCO materials with higher TLIESST: increasing the stiffness of the coordination sphere, optimizing the spin-orbit coupling via heavier atoms (particularly in the inner coordination sphere), and minimizing the enthalpy difference between the high-spin (HS) and low-spin (LS) states can all increase TLIESST. However, the most dramatic increases arise from increasing the cooperativity of the spin-state transition by increasing the rigidity of the crystal. Increased crystal rigidity can also stabilize the HS state to low temperatures on thermal cycling, yet leave the LS state stable at high temperatures following, for example, reverse-LIESST. We show that such highly cooperative systems offer a realistic route to robust room temperature switching, demonstrate this in silico, and discuss material design rationale to realize this experimentally.
Co-design of zinc titantium nitride semiconductor towards durable photoelectrochemical applications
Authors: Greenaway Ann L. , Ke Sijia , Culman Theodore , Talley Kevin R. , Mangum John S. , Heinselman Karen N. , Kingsbury Ryan S. , Smaha Rebecca W. , Miller Elisa M. , Persson Kristin A. , Gregoire John M. , Bauers Sage R. , Neaton Jeffrey B. , Tamboli Adele C. , Zakutayev Andriy
Published: March 2022

Photoelectrochemical fuel generation is a promising route to sustainable liquid fuels produced from water and captured carbon dioxide with sunlight as the energy input. Development of such technologies requires photoelectrode materials that are both photocatalytically active and operationally stable in harsh oxidative and/or reductive electrochemical environments. Such photocatalysts can be discovered based on co-design principles, wherein design for stability is based on the propensity for the photocatalyst to self-passivate under operating conditions and design for photoactivity is based on the ability to integrate the photocatalyst with established semiconductor substrates. Here we report on synthesis and characterization of zinc titanium nitride (ZnTiN2) that follows these design rules by having a wurtzite-derived crystal structure and showing self-passivating surface oxides created by electrochemical polarization. The sputtered ZnTiN2 thin films have optical absorption onsets below 2 eV and n-type electrical conduction of 0.1 S/cm. The band gap of this material is reduced from the 3.5 eV theoretical value by cation site disorder, and the impact of cation antisites on the band structure of ZnTiN2 is explored using density functional theory. Under electrochemical polarization, the ZnTiN2 surfaces have TiO2- or ZnO-like character, consistent with Materials Project Pourbaix calculations predicting the formation of stable solid phases under near-neutral pH. These results show that ZnTiN2 is a promising candidate for photoelectrochemical liquid fuel generation and demonstrate a new materials design approach to other photoelectrodes with self-passivating native operational surface chemistry.
Synthesis and styrene copolymerization of novel ring-substituted isobutyl phenylcyanoacrylates
Authors: Abuelroos Samer A. , Czech Katherine A. , Francis Divya V. , Fricano Adriana M. , Gaona Mariana , Huene Jason T. , Nagani Jawairia A. , Pecoraro Cristina M. , Rivero Dayessi L. , Stone Sydney A. , Udine Marissa R. , Rocus Sara M. , Schjerven William S. , Kharas Gregory B.
Published: March 2022

Novel ring-substituted isobutyl phenylcyanoacrylates, RPhCH=C(CN)CO2CH2CH(CH3)2 , where R is 2-ethyl, 4-(4-bromophenoxy), 2-(4-chlorophenoxy), 2-(4-fluorophenoxy), 4-(4-methoxyphenoxy), 3-(4-methylphenyl), 4-(4-methylphenyl), 4-acetoxy, 2,5-dimethyl were synthesized by the piperidine catalyzed Knoevenagel condensation of ring-substituted benzaldehydes and isobutyl cyanoacetate and characterized by CHN analysis, IR, 1H and 13C NMR. The acrylates were copolymerized with styrene in solution with radical initiation (ABCN) at 70C. The compositions of the copolymers were calculated from nitrogen analysis.
Determination on Antioxidant Activity of Sansevieria cylindrica Bojer ex Hook. Leaf Extract
Authors: Hanna Jeeja Alexander  , Bojaxa A. Rosy  , Ani Besant S  , Jancy Rani G  , Catherine Sheeja V  , Blessy R
Published: March 2022

Antioxidant compounds work by preventing or detecting oxidative chain reactions caused by free radicals, stabilizing generated radicals and thus reducing the risk of oxidative damage in the body. They are sometimes called as free radical scavengers. Plants are naturally rich in antioxidants which contains bioactive compounds with high antioxidant activity. The work was carried out to verify whether different types of method shows the same sensitivity and/or capacity to determine the antioxidant activity of two different extract of Sansevieria cylindrica Bojer ex Hook. Their extracts were analyzed using 4 four different methods (i) DPPH (ii) Hydrogen peroxide (iii) Superoxide (iv) Nitric Oxide scavenging activities. These four methods could quantify the antioxidant capacity. Antioxidant evaluation methods must be fast, reproducible, require small amounts of the chemical compounds being analyzed, and not be affected by the physical characteristics of the compounds. The highest antioxidant activity was observed in both the extracts 13.6% (Ethanolic extract) and 13.9% (Chloroform extract) in 20µg/ml concentration of DPPH activity and the lowest antioxidant activity was also observed in ethanolic extract of Nitric oxide radical scavenging activity 68.7% in 100µg/ml concentration. Finally the application of DPPH free radicals are higher than the results of other three methods of free radical activity.
Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly
Authors: Matsumori Haruka , Watanabe Kenji , Tachiwana Hiroaki , Fujita Tomoko , Ito Yuma , Tokunaga Makio , Sakata-Sogawa Kumiko , Osakada Hiroko , Haraguchi Tokuko , Awazu Akinori , Ochiai Hiroshi , Sakata Yuka , Ochiai Koji , Toki Tsutomu , Ito Etsuro , Goldberg Ilya G , Tokunaga Kazuaki , Nakao Mitsuyoshi , Saitoh Noriko
Published: March 2022

The nucleolus is the site of ribosome assembly and formed through liquid–liquid phase separation. Multiple ribosomal DNA (rDNA) arrays are bundled in the nucleolus, but the underlying mechanism and significance are unknown. In the present study, we performed high-content screening followed by image profiling with the wndchrm machine learning algorithm. We revealed that cells lacking a specific 60S ribosomal protein set exhibited common nucleolar disintegration. The depletion of RPL5 (also known as uL18), the liquid–liquid phase separation facilitator, was most effective, and resulted in an enlarged and un-separated sub-nucleolar compartment. Single-molecule tracking analysis revealed less-constrained mobility of its components. rDNA arrays were also unbundled. These results were recapitulated by a coarse-grained molecular dynamics model. Transcription and processing of ribosomal RNA were repressed in these aberrant nucleoli. Consistently, the nucleoli were disordered in peripheral blood cells from a Diamond–Blackfan anemia patient harboring a heterozygous, large deletion in RPL5. Our combinatorial analyses newly define the role of RPL5 in rDNA array bundling and the biophysical properties of the nucleolus, which may contribute to the etiology of ribosomopathy.