bluuebunny/crossref_metadata_2025 huggingface dataset:
Dental Prosthetic Rehabilitation Interventions in Elderly Patients Hospitalized in the Nursing Homes of the Lombardy Region: A Retrospective Study
Authors: Ceraulo Saverio , Caccianiga Paolo , Casto Carmelo , Ceraulo Ignazio , Caccianiga Gianluigi
Published: November 2022

Background: The difficulty of frail, non-self-sufficient or non-ambulatory collaborating elderly residents in nursing homes to eat due to a lack of teeth or the absence of a dental prosthesis leads to an increasingly evident increase in the patients’ systemic pathological state, particularly in older patients who take a lot of medications. Total or partial edentulousness that is not filled with dental prostheses or that is filled with inadequate prostheses, associated with socioeconomic factors, depression, impaired motor functions, heart disease and a large number of chronic diseases including excessive use of drugs, often affects elderlies’ feeding. Aim: In this study, prosthetic rehabilitation was performed on some frail elderly residents in 10 nursing homes in the Lombardy district, and, subsequently, meal behavior and social activity were examined in two information questionnaires through compilation. Methods: The research was conducted on only 67 patients, 26 men and 41 women, aged between 75 and 99, who were guests in 10 health facilities (nursing homes) in the Lombard district; only 8 residents did not undergo prosthetic rehabilitation, as they did not cooperate. All the patients who were visited underwent oral prosthetic rehabilitation, and, subsequently, some aspects such as nutrition and socialization were assessed with other residents through the aid of two information dossiers. Results: the results showed that all the residents, despite difficulties in chewing with the new prosthesis, were fed and did not refuse more consistent foods; in addition, there was an improvement in social activity among the residents. Only 19.3% of men and 22% of women continued to eat little; there was an improvement in the participation in social activities among the residents, with a percentage of 73% of men and 88% of women; in particular, during meals 35 residents conversed with the other residents. Discussion: The dental problems of elderly people residing in social welfare homes are increasingly evident when other systemic pathologies are present. It would be desirable to introduce telemedicine in residences for the elderly for the monitoring of dental problems. Conclusions: From the information obtained and from the evaluation of the change in the elderly, it can be concluded that it would be desirable to include specific dental protocols to create a network, including a telematic one, to monitor and perform more dental checks in nursing homes.
Microanalytical Determinations to Distinguish Maiolica and Mezza Majolica Ceramics from Faenza (Emilia-Romagna Region, Italy)
Authors: Marrocchino Elena , Paletta Maria Grazia , Telloli Chiara
Published: November 2022

Post-Renaissance ceramics (XVI–XIX) obtained in the Emilia Romagna region (north of Italy) demonstrate the difficulty in correctly identifying two different main types of artifacts: (i) enamel terracotta (or majolica) and (ii) glazed engobed terracotta (or mezza-majolica). This problem arises from the fact that the two different artifacts have the same shape, mixture, and even the same decoration in terms of color and style. Based only on macroscopic observation, the distinction between majolica and mezza-majolica could be problematic. This study aims to propose an immediate identification of the finds by diagnostic investigations to achieve identification of the type of coating applied. Different kinds of archeological finds were collected during a restoration of an important building in the city center of Faenza, Italy, and were analyzed by optical transmitted light polarized microscopy on thin sections, scanning electron microscope (SEM-EDS), and colorimetry analysis. The results identified two types of clayey material; one was Fe enriched carbonate clay and the other had Fe enriched non carbonate clay used in the production of the ceramic artifact. The analysis also distinguishes the different techniques by which the artifacts were produced, either by single firing or by double firing.
Gibberellic Acid Concentrations and Storage of Caryocar brasiliense (Caryocaraceae) Seeds Propagated in Tubes
Authors: Lacerda Vander Rocha , Pagehú Levi Fraga , Gonçalves Armando Pego , Vieites Rogério Lopes , Lopes Paulo Sérgio Nascimento
Published: November 2022

The immersion of seeds in gibberellic acid solutions can promote dormancy breaking. Storage can be dynamic in seed longevity. The objective of this work was to evaluate different concentrations of gibberellic acid applied to seeds isolated from two storage times on the emergence of C. brasiliense tree seedlings grown in tubes. There were two experiments with different planting and storage times. The seeds were extracted from the endocarp. In both, a randomized block design was used with the following seven treatments: 0, 50, 100, 500, 1000 and 2000 mg L−1 of GA3 and dry seeds without pre-soaking, with five replications of 20 seeds. The seeds were treated with fungicide and sown in tubes containing substrate. After 60 days, evaluations and transplantation were carried out. In the experiment with older pyrenes (seeds stored for seven months), there was high seed mortality (96.54%) and a small emergence rate (3.45%). On the other hand, when new pyrenes were used, the percentage of dead seeds was 32.71% and emergence was 62.28%. GA3 did not stimulate germination or the diameter of C. brasiliense tree seedlings, except for stem length. The 2000 concentration provided a greater stem length and greater leaf area compared to dry seeds.
Formation and Detection of Hydrogen by Oxygen Discharge Using Oxygen Pump-Sensor
Authors: Fukumoto Michihisa , Nakajima Kano
Published: November 2022

An oxygen pump sensor was constructed using yttria-stabilized zirconia, which is an oxide ion conductor, and oxygen was discharged from steam to generate hydrogen. The oxygen pump sensor consisted of a pump that discharges oxygen and a sensor that controls the oxygen partial pressure by having electrodes in two places. Oxygen was discharged by applying a current to the pump by controlling the potential of the sensor. Hydrogen was then generated from water vapor. Furthermore, an oxygen pump sensor was installed in the second stage, oxygen was supplied by the pump, and the amount of generated hydrogen was measured in situ. This measurement showed that the oxygen partial pressure of the atmosphere decreased as hydrogen was generated. Specifically, the partial pressure of the water vapor generated more hydrogen at 30.8 vol.% than at 12.2 vol.%. Moreover, the amounts of oxygen discharged and hydrogen generated inversely correlated with the potential.
Gender-Specific Effects of 8-Week Multi-Modal Strength and Flexibility Training on Hamstring Flexibility and Strength
Authors: Li Shangxiao , Wang Liduan , Xiong Jinfeng , Xiao Dandan
Published: November 2022

The purpose of this study was to investigate the effects of multi-modal strength training or flexibility training on hamstring flexibility and strength in young males and females. A total of 20 male and 20 female college students (aged 18–24 years) participated in this study and were randomly assigned to either a multi-modal flexibility intervention group or strength intervention group. Passive straight leg raise and isokinetic strength test were performed before and after the intervention to determine flexibility and strength of the participants. Multivariate repeated-measure ANOVA was used to determine the effect of training group and gender on hamstring strength and flexibility. Both male and female participants in the strength intervention group significantly increased peak torque, relative peak torque, and flexibility (all p ≤ 0.029). Both male and female participants in the flexibility intervention group significantly increased flexibility (both p ≤ 0.001). Female participants in the flexibility intervention group significantly increased peak torque and relative peak torque (both p ≤ 0.023). However, no change was seen in peak torque and relative peak torque of male participants in the flexibility intervention group (p ≥ 0.676). An 8-week strength training program involving various training components can increase flexibility in both males and females, although the flexibility of male participants only increased slightly. While hamstring flexibility training protocol consisted of different types of stretching improved both flexibility and strength in female participants, male participants increased only flexibility but not strength, indicating such effects were gender-specific. For subjects with relatively low strength (e.g., older adults, sedentary women, postoperative rehabilitation population, etc.), strength training alone or flexibility training alone may increase both strength and flexibility.
The Role of a Restorative Resource in the Academic Context in Improving Intrinsic and Extrinsic Motivation and Flow within the Job Demands–Resources Model
Authors: Bellini Diego , Barbieri Barbara , Barattucci Massimiliano , Mascia Maria Lidia , Ramaci Tiziana
Published: November 2022

The perceived quality of the learning environment may influence both motivation and concentration. Little is known about how perceived characteristics of the learning environment, and specifically sub-dimensions of Perceived Restorativeness (being away, fascination, compatibility, and extent), can promote these positive effects in an academic context. We addressed, through a correlational study, the possibility that the characteristics of learning environments may promote concentration and involvement in activity (i.e., flow) via intrinsic and extrinsic motivation for academic study within the job demands–resources model. A total of 165 Italian university psychology classes in a 3-year degree course from two different universities context completed an online questionnaire made up of the construct considered in this study. Results in the hierarchical multivariate regression analyses confirm that the restorative quality of learning environments (i.e., being away, compatibility, extent) is positively correlated with flow. However, there is a non-significant relationship between extent and flow. Regression analyses show a significant indirect effect of compatibility, both through intrinsic and extrinsic student motivation. Furthermore, the results confirm a significant indirect effect of extent through intrinsic motivation and being away, and fascination through Extrinsic motivation. Furthermore, intrinsic motivation is a full mediator between the extent and flow relationship. The results underline the importance of considering the restorative quality of the environment for improving place design, concentration, and student learning motivation.
Assessing the Underestimation of HIV Risk Infection among Young Men Who Have Sex with Men in Argentina
Authors: Feijoo-Cid Maria , Fernández-Cano María Isabel , Zalazar Virginia , Moriña-Soler David , García-Sierra Rosa , Arreciado Marañón Antonia , Sued Omar
Published: November 2022

The aim of this study is to describe the discordance between the self-perceived risk and actual risk of HIV among young men who have sex with men (YMSM) and its associated factors. An online, cross-sectional study was conducted with 405 men recruited from an Argentinian NGO in 2017. Risk discordance (RD) was defined as the expression of the underestimation of risk, that is, as a lower self-perception of HIV risk, as measured with the Perceived Risk of HIV Scale, than the current risk of HIV infection, as measured by the HIV Incidence Risk Index. Multivariate logistic regression models were used to analyze the associations between the RD and the explanatory variables. High HIV risk was detected in 251 (62%), while 106 (26.2%) showed high self-perceived risk. RD was found in 230 (56.8%) YMSM. The predictors that increased RD were consistent condom use with casual partners (aOR = 3.8 [CI 95:1.5–11.0]), the use of Growler to meet partners (aOR = 10.38 [CI 95:161–121.94]), frequenting gay bars (aOR = 1.9 [95% CI:1.1–3.5]) and using LSD (aOR = 5.44 [CI 95:1.32–30.29]). Underestimation of HIV risk in YMSM is associated with standard HIV risk behavior and modulated by psychosocial aspects. Thus, prevention campaigns aimed at YMSM should include these factors, even though clinical practice does not. Health professionals should reconsider adapting their instruments to measure the risk of HIV in YMSM. It is unknown what score should be used for targeting high-risk YMSM, so more research is needed to fill this gap. Further research is needed to assess what score should be used for targeting high-risk in YMSM.
Mediating Effects of Rehabilitation Motivation between Social Support and Health-Related Quality of Life among Patients with Stroke
Authors: Lee Yaeram , Won Mihwa
Published: November 2022

Post-stroke health-related quality of life (HRQoL) is poor, which is related to low social support levels and lack of rehabilitation motivation. However, there are limited studies that have systematically analyzed the mechanisms underlying this relationship in stroke patients. This study aimed to identify the mediating effects of rehabilitation motivation on the relationship between social support and HRQoL among stroke patients. A cross-sectional descriptive study was conducted on 176 Koreans aged ≥19 years who were admitted for rehabilitation treatment after stroke at three general hospitals in Jeonbuk. Data collection was conducted from September to December 2020 through face-to-face interviews using structured questionnaires and review of medical records. The significance of the mediation model was tested using SPSS 25.0 and the PROCESS macro for SPSS v3.5. Significant associations were identified between social support and HRQoL. Our findings revealed an indirect effect, suggesting that the effects of social support on HRQoL are mediated by rehabilitation motivation (B = 0.004, 95% bias-corrected bootstrap confidence interval = 0.002, 0.006). Social support for stroke patients had a positive effect on HRQoL, and rehabilitation motivation was found to have a partial mediating effect on this relationship. This study suggests that social support from healthcare professionals and families for post-stroke can improve patients’ HRQoL by inducing positive rehabilitation motivation. Therefore, developing intervention strategies to motivate rehabilitation could improve the HRQoL of patients with stroke.
Analyzing Construction Workers’ Unsafe Behaviors in Hoisting Operations of Prefabricated Buildings Using HAZOP
Authors: Zhu Lianbo , Ma Hongxin , Huang Yilei , Liu Xun , Xu Xiaojin , Shi Zhenqun
Published: November 2022

Along with the increasing number of prefabricated buildings being constructed in China each year, the incident rate of hoisting operations has been continuously rising. In order to improve construction safety in hoisting operations of prefabricated buildings, this paper analyzes the construction workers’ unsafe behaviors using the Hazard and Operability (HAZOP) method. A questionnaire survey and a literature review were first performed to gather information on safety risks and influencing factors during each stage of hoisting operations, and the survey results were statistically analyzed using the SPSS software. Next, HAZOP was applied to identify the deviation and change of the unsafe behaviors as well as their causes, consequences, and countermeasures. Finally, a case study was presented to verify the effectiveness of the countermeasures through a comparison and evaluation method from experimental economics. This paper demonstrates the use of HAZOP to analyze construction workers’ unsafe behaviors in hoisting operations of prefabricated buildings, and effective countermeasures in each stage of hoisting operations are proposed to mitigate unsafe behaviors. This paper therefore provides an innovative method and a theoretical foundation for reducing unsafe behaviors in hoisting operations of prefabricated buildings and serves as a reference for decision-making for hoisting safety policies in prefabricated construction projects.
PREVIDE: A Qualitative Study to Develop a Decision-Making Framework (PREVention decIDE) for Noncommunicable Disease Prevention in Healthcare Organisations
Authors: Canfell Oliver J. , Davidson Kamila , Sullivan Clair , Eakin Elizabeth E. , Burton-Jones Andrew
Published: November 2022

Noncommunicable diseases (NCDs), including obesity, remain a significant global public health challenge. Prevention and public health innovation are needed to effectively address NCDs; however, understanding of how healthcare organisations make prevention decisions is immature. This study aimed to (1) explore how healthcare organisations make decisions for NCD prevention in Queensland, Australia (2) develop a contemporary decision-making framework to guide NCD prevention in healthcare organisations. Cross-sectional and qualitative design, comprising individual semi-structured interviews. Participants (n = 14) were recruited from two organisations: the state public health care system (CareQ) and health promotion/disease prevention agency (PrevQ). Participants held executive, director/manager or project/clinical lead roles. Data were analysed in two phases (1) automated content analysis using machine learning (Leximancer v4.5) (2) researcher-led interpretation of the text analytics. Final themes were consolidated into a proposed decision-making framework (PREVIDE, PREvention decIDE) for NCD prevention in healthcare organisations. Decision-making was driven by four themes: Data, Evidence, Ethics and Health, i.e., data, its quality and the story it tells; traditional and non-traditional sources of evidence; ethical grounding in fairness and equity; and long-term value generated across multiple determinants of health. The strength of evidence was directly proportional to confidence in the ethics of a decision. PREVIDE can be adapted by public health practitioners and policymakers to guide real-world policy, practice and investment decisions for obesity prevention and with further validation, other NCDs and priority settings (e.g., healthcare).
Word2vec Word Embedding-Based Artificial Intelligence Model in the Triage of Patients with Suspected Diagnosis of Major Ischemic Stroke: A Feasibility Study
Authors: Desai Antonio , Zumbo Aurora , Giordano Mauro , Morandini Pierandrea , Laino Maria Elena , Azzolini Elena , Fabbri Andrea , Marcheselli Simona , Giotta Lucifero Alice , Luzzi Sabino , Voza Antonio
Published: November 2022

Background: The possible benefits of using semantic language models in the early diagnosis of major ischemic stroke (MIS) based on artificial intelligence (AI) are still underestimated. The present study strives to assay the feasibility of the word2vec word embedding-based model in decreasing the risk of false negatives during the triage of patients with suspected MIS in the emergency department (ED). Methods: The main ICD-9 codes related to MIS were used for the 7-year retrospective data collection of patients managed at the ED with a suspected diagnosis of stroke. The data underwent “tokenization” and “lemmatization”. The word2vec word-embedding algorithm was used for text data vectorization. Results: Out of 648 MIS, the word2vec algorithm successfully identified 83.9% of them, with an area under the curve of 93.1%. Conclusions: Natural language processing (NLP)-based models in triage have the potential to improve the early detection of MIS and to actively support the clinical staff.
A Comprehensive Evaluation System for the Stabilization Effect of Heavy Metal-Contaminated Soil Based on Analytic Hierarchy Process
Authors: Zhang Suxin , Hu Cheng , Cheng Jiemin
Published: November 2022

Stabilization technology is widely used in the remediation of heavy metal-contaminated farmland soil. However, the evaluation method for the remediation effect is not satisfactory. To scientifically evaluate the remediation effect, this study constructed a comprehensive evaluation system by bibliometric analysis and an analytic hierarchy process (AHP). Ultimately, 16 indicators were selected from three aspects of the soil, crops, and amendment. The 16 indicators are divided into three groups, namely indicators I that can be evaluated according to the national standards of China, indicators II that can be evaluated according to the classification management of farmland and Indicators III that are the dynamic change indicators without an evaluation criterion. Comprehensive scores for 16 indicators were calculated using three response models, respectively. According to the difference between the scores before and after the remediation, the remediation effect is divided into five levels, which are excellent, good, qualified, poor, and very poor. This study provides a theoretical basis and insightful information for a farmland pollution remediation and a sustainable utilization.
A Novel Index in the Prediction of Pneumonia Following Acute Ischemic Stroke
Authors: Szylińska Aleksandra , Bott-Olejnik Marta , Wańkowicz Paweł , Karoń Dariusz , Rotter Iwona , Kotfis Katarzyna
Published: November 2022

Background: The aim of our study was to search for predictive factors and to develop a model (index) for the risk of pneumonia following acute ischemic stroke. Material and methods: This study is an analysis of prospectively collected data from the neurology department of a district general hospital in Poland, comprising 1001 patients suffering from an acute ischemic stroke. Based on the medical data, the formula for the prediction of pneumonia was calculated. Results: Multivariate assessment for pneumonia occurrence was performed using the new PNEUMOINDEX. The study showed a significant increase in pneumonia risk with an increasing PNEUMOINDEX (OR non-adjusted = 2.738, p < 0.001). After accounting for age and comorbidities as confounders, the effect of the Index on pneumonia changed marginally (OR = 2.636, p < 0.001). Conclusions: This study presents factors that show a significant association with the occurrence of pneumonia in patients with acute ischemic stroke. The calculated PNEUMOINDEX consists of data obtained at admission, namely NYHA III and IV heart failure, COPD, generalized atherosclerosis, NIHHS score on admission, and CRP/Hgb ratio, and shows high prediction accuracy in predicting hospital-acquired pneumonia in ischemic stroke patients.
Perceived Consequences of Post-COVID-19 and Factors Associated with Low Life Satisfaction
Authors: Ekstrand Elisabeth , Brogårdh Christina , Axen Iben , Fänge Agneta Malmgren , Stigmar Kjerstin , Hansson Eva Ekvall
Published: November 2022

A significant number of individuals experience post-COVID-19 symptoms, but knowledge of perceived consequences and life satisfaction is lacking. Here, we investigate perceived consequences regarding everyday life, health, physical activity and work post-COVID-19 and factors associated with low life satisfaction. A total of 766 people (mean age 48; 672 women) experiencing post-COVID-19 symptoms at least two months after infection (mean 13 months) responded to an online survey. A majority (≥77%) perceived physical fatigue, mental fatigue, dizziness, reduced work ability, low life satisfaction and a reduced level of aerobic capacity. In the final logistic regression model (Nagelkerke R Square 0.296, p < 0.001), poor work ability was the most important factor for perceiving low satisfaction with life (Odds ratio 3.369, 95% CI 2.040–5.565, p < 0.001, Nagelkerke R Square 0.177). Reduced aerobic capacity, fatigue and living in a city also increased the odds of low life satisfaction. As people with post-COVID-19 report several long-term consequences, this suggests that there is a need for targeted care for this group. The results of this study can serve as guidance for healthcare authorities regarding important long-term consequences that should be considered in rehabilitation programs directed toward post-COVID-19.
Study Protocol of “Sustainably Healthy—From Science 2 Highschool & University”—Prevalence of Mixed, Vegetarian, and Vegan Diets Linked to Sports & Exercise among Austrian Tertiary Students and Lecturers/Academic Staff
Authors: Wirnitzer Katharina C. , Motevalli Mohamad , Tanous Derrick R. , Wirnitzer Gerold , Wagner Karl-Heinz , Cocca Armando , Schätzer Manuel , Kirschner Werner , Drenowatz Clemens , Ruedl Gerhard
Published: November 2022

Healthy lifestyle is the major indicator of individual and public health especially in target populations (e.g., during emerging adulthood). Evidence indicates that unhealthy lifestyle behaviors are strongly associated with the increasing prevalence of chronic diseases. The dual approach of sustainable health (i.e., physical exercise tied to a healthy diet) is an effective lifestyle strategy to control and manage health-related disorders, including overweight/obesity. Based on the evidence on plant-based diets regarding health and considering the growing prevalence of vegans and vegetarians worldwide, limited data exist on the health-related behaviors of those who follow plant-based vs. mixed diets in young adulthood. This multidisciplinary study is the first to examine the association between diet type (mixed, vegetarian, and vegan diets) and various health-related behaviors (primarily physical activity, sport, & exercise) among college/university students and lecturers/academic staff in Austria nationwide. Following a cross-sectional study design and using online questionnaires, 4510 tertiary students and 1043 lecturers/academic staff provided data on sociodemographic characteristics, dietary patterns, physical exercise habits, and other lifestyle behaviors (sleep, alcohol intake, smoking, etc.) along with information on health status and quality of life. While the data will be analyzed based on differentiated sociodemographic and health-related categories, the influence of the COVID-19 pandemic on lifestyle behaviors will also be evaluated. As a study protocol, this article represents comprehensive details of the design, purposes, and associated analytical measures of the present study within the tertiary educational context.
Development of the Korean Medicine Core Outcome Set for Primary Dysmenorrhea (COS-PD-KM) for Herbal Medicine Treatment of Primary Dysmenorrhea in Primary Clinics
Authors: Kim Pyung-Wha , Kim Sungha , Kim Dong-Il , Cha Jiyun , Lee He-Sol , Ko Mi Mi , Jang Soobin , Yang Changsop , Lee Myeong Soo
Published: November 2022

The aim of this study was to develop a Korean medicine (KM) core outcome set (COS) for primary dysmenorrhea to evaluate the effectiveness of herbal medicine (HM) in treating primary dysmenorrhea in patients visiting KM primary clinics. Previously reported outcomes were identified through a literature review to define outcomes and effect modifiers (EMs) for the questionnaire. Experts were invited to conduct modified Delphi consensus exercises, and primary care clinicians were invited to conduct Delphi consensus exercises to evaluate suitability and feasibility. Finally, an additional round of a modified Delphi exercise was conducted with experts to obtain a final agreement on the COS. Seventeen outcomes and 15 EMs were included from a literature review, and one effect modifier was suggested by the experts (Phase 1). In Phase 2, after the modified Delphi consensus exercises by experts, 10 outcomes and 11 EMs were included in the COS. The clinicians all agreed on the feasibility of COS (Phase 3). Finally, 10 outcomes and 6 EMs were included in the COS-PD-KM after the final modified Delphi consensus exercise (Phase 4). The effectiveness of HM used in primary clinics could be evaluated with this COS in patients with primary dysmenorrhea. Further studies that involve more relevant stakeholder groups, such as patient representatives and gynecological experts, are needed.
Remote Working and Work Effectiveness: A Leader Perspective
Authors: Kowalski Grzegorz , Ślebarska Katarzyna
Published: November 2022

Currently, job duties are massively transferred from in-person to remote working. Existing knowledge on remote working is mainly based on employees’ assessment. However, the manager’s perspective is crucial in organizations that turned into remote work for the first time facing sudden circumstances, i.e., SARS-CoV-2 pandemic. The main aim of our study was to analyze remote work effectiveness perceived by managers (N = 141) referring to three crucial aspects, i.e., manager, team, and external cooperation. We assumed the perceived benefits, limitations, and online working frequency as predictors of remote work effectiveness. Further, we analyzed the possible differences in remote work perception referring to different management levels (i.e., middle-level and lower-level). Our findings revealed a significant relationship between the benefits and effectiveness of managers and external cooperation, specifically among lower-level managers. Limitations, particularly technical and communication issues, predicted team and external cooperation effectiveness. The results showed remote work assessment as being socially diverse at the management level.
Development of Predictive Models for Survival among Women with Breast Cancer in Malaysia
Authors: Nik Ab Kadir Mohd Nasrullah , Yaacob Najib Majdi , Yusof Siti Norbayah , Ab Hadi Imi Sairi , Musa Kamarul Imran , Mohd Isa Seoparjoo Azmel , Bahtiar Balqis , Adam Farzaana , Yahya Maya Mazuwin , Hairon Suhaily Mohd
Published: November 2022

Prediction of survival probabilities based on models developed by other countries has shown inconsistent findings among Malaysian patients. This study aimed to develop predictive models for survival among women with breast cancer in Malaysia. A retrospective cohort study was conducted involving patients who were diagnosed between 2012 and 2016 in seven breast cancer centres, where their survival status was followed until 31 December 2021. A total of 13 predictors were selected to model five-year survival probabilities by applying Cox proportional hazards (PH), artificial neural networks (ANN), and decision tree (DT) classification analysis. The random-split dataset strategy was used to develop and measure the models’ performance. Among 1006 patients, the majority were Malay, with ductal carcinoma, hormone-sensitive, HER2-negative, at T2-, N1-stage, without metastasis, received surgery and chemotherapy. The estimated five-year survival rate was 60.5% (95% CI: 57.6, 63.6). For Cox PH, the c-index was 0.82 for model derivation and 0.81 for validation. The model was well-calibrated. The Cox PH model outperformed the DT and ANN models in most performance indices, with the Cox PH model having the highest accuracy of 0.841. The accuracies of the DT and ANN models were 0.811 and 0.821, respectively. The Cox PH model is more useful for survival prediction in this study’s setting.
Coping and Protective Factors of Mental Health: An Examination of African American and US Caribbean Black Women Exposed to IPV from a Nationally Representative Sample
Authors: Parnell Regina N. , Lacey Krim K. , Wood Maxine
Published: November 2022

Existing research continues to highlight the harm that intimate partner violence (IPV) can pose to health and well-being. However, little is done to understand the effectiveness of coping and protective mechanisms in helping women manage under adverse circumstances. The current study addresses the mental health of US Black women and the role of coping and protective moderators. An analysis of data from the National Survey of American Life (2001–2003), the most comprehensive survey on the health of US Blacks, was conducted. The association between severe physical intimate partner violence and mental health outcomes were confirmed. Resilience moderated the relationship between severe intimate partner violence and mood disorder among US Black women, but this differed between African American and Caribbean Blacks. Resilience, emotional family support, and spirituality reduced the likelihood of having a mental health condition for some African American and Caribbean Black women, while the opposite was found for religiosity. Demographic factors were also associated with mental health conditions and behaviors. The study draws our attention to potential coping and protective mechanisms that could be incorporated into counseling and intervention practices while recognizing factors that may be harmful to the mental health of individuals.
Rehabilitation of Post-COVID-19 Musculoskeletal Sequelae in Geriatric Patients: A Case Series Study
Authors: Cevei Mariana , Onofrei Roxana Ramona , Gherle Anamaria , Gug Cristina , Stoicanescu Dorina
Published: November 2022

The musculoskeletal system is affected in over 40% of patients with Coronavirus disease 2019 (COVID-19). There is an increased need for post-acute rehabilitation after COVID-19, especially in elderly people with underlying health problems. The aim of this study was to evaluate the benefits of an early and goal-orientated rehabilitation program using combined approaches, robotic medical devices together with other rehabilitation techniques and therapies, in elderly people after acute COVID-19. Ninety-one patients (62.64 ± 14.21 years) previously diagnosed with severe SARS-CoV-2 infection were admitted to the Medical Rehabilitation Clinical Hospital Baile Felix, Romania, for medical rehabilitation, but only six patients (85.33 ± 3.07 years) met the inclusion criteria and participated in the study. The rehabilitation treatment was complex, performed over 4 weeks, and included combined approaches: exercise therapy, robotic gait training, occupational therapy, and massages. Activity and participation evaluation were performed using the Barthel Index and Functional Independence Measure for activities of daily living (ADLs). Assessments were performed at admission and discharge from the rehabilitation clinic. Lokomat patients’ reports revealed that the patients had improved motor control (with one exception). The measurement of functional ability revealed an improvement in most cases. This study presents some of the first data on outcomes of COVID-19 patients’ musculoskeletal rehabilitation in our country. Early complex medical rehabilitation improved functional independence and autonomy in ADLs in very old patients, post-COVID-19.
Willingness of Tea Farmers to Adopt Ecological Agriculture Techniques Based on the UTAUT Extended Model
Authors: Xie Kexiao , Zhu Yuerui , Ma Yongqiang , Chen Youcheng , Chen Shuiji , Chen Zhidan
Published: November 2022

Ecological agricultural technology is the key method for making the transition from traditional agriculture to ecological agriculture, and is also the basic measure for promoting the transformation and upgrading of the tea industry and sustainable development. This study explores the influencing factors and mechanisms of tea farmers’ adoption of ecological agricultural technology by using the extended model of the unified theory of technology adoption and use (UTAUT) based on perceived value. The analysis results, using the partial least squares structural equation model (PLS-SEM), show that: the positive impact of perceived value on willingness to use not only makes the explanatory power of the extended model greater than that of the original model but also expands the UTAUT model into a full mediating model, in which performance expectation has the greatest impact on behavioral intention through the implemented value. Effect expectation, social influence and factoring factors following, then the four intermediary paths have significant positive effects on behavioral intention. This study improves on the limitations of the UTAUT theoretical model through the theory of perceived value, and provides a reference for research on the same topic. At the same time, the government should provide tea farmers with enhanced subsidies, skills training and communication platforms.
Clinical Use of Lansoprazole and the Risk of Osteoporosis: A Nationwide Cohort Study
Authors: Chung Ming-Hsuan , Chen Yong-Chen , Wu Wen-Tung , Lin Ming-Hsun , Yang Yun-Ju , Hueng Dueng-Yuan , Lin Tsung-Kun , Chou Yu-Ching , Sun Chien-An
Published: November 2022

Background: Proton pump inhibitor (PPI) lansoprazole acts as a liver X receptor agonist, which plays a crucial role in the crosstalk of osteoblasts and osteoclasts in vitro and during bone turnover in vivo. However, epidemiological studies on the association between the use of lansoprazole and osteoporosis risk are limited. We aimed to determine the risk of developing osteoporosis in patients with lansoprazole use. Methods: A retrospective cohort study was conducted using the National Health Insurance Research Database of Taiwan dated from 2000 to 2013. The study includes 655 patients with lansoprazole use (the exposed cohort) and 2620 patients with other PPI use (the comparison cohort). The main outcome was the primary diagnosis of osteoporosis. The hazard ratios (HRs) and 95% confidence intervals (CIs) were used to assess the association between the use of lansoprazole and risk of osteoporosis. Results: Patients receiving lansoprazole treatment had a reduced risk of osteoporosis as compared with those undergoing other PPI therapy (adjusted HR, 0.56; 95% CI, 0.46–0.68). Moreover, this inverse association is evident in both sexes and in various age groups. Conclusions: This population-based cohort study demonstrated that lansoprazole use was associated with a reduced risk of osteoporosis. The clinical implications of the present study need further investigations.
Oral Contraceptive Use and Assessment of Breast Cancer Risk among Premenopausal Women via Molecular Characteristics: Systematic Review with Meta-Analysis
Authors: Barańska Agnieszka
Published: November 2022

Breast cancer is divided into four molecular subtypes. Each one has distinct clinical features. The aim of this study was to assess individual breast cancer subtype risk in premenopausal women taking oral contraceptives (OCs). Databases (MEDLINE; PubMed, EMBASE, and the Cochrane Library) were searched to January 2022 to identify case-control studies meeting the inclusion criteria. The influence of OCs intake on the risk of ER-positive breast cancer (ER+BC) was revealed to be non-significant with regard to reduction: OR = 0.9134, 95% CI: 0.8128 to 1.0265, p = 0.128. Assessment of ER-negative subtype breast cancer (ER−BC) risk indicated that OCs use significantly increased the risk: OR = 1.3079, 95% CI: 1.0003 to 1.7100, p = 0.050. Analysis for HER2-positive breast cancer (HER2+BC) risk showed that OCs use statistically non-significantly lowered the risk: OR = 0.8810, 95% CI: 0.5977 to 1.2984, p = 0.522. Meta-analysis with regard to Triplet-negative breast cancer (TNBC) risk showed non-statistically significant increased risk: OR = 1.553, 95% CI: 0.99 to 2.43, p = 0.055. The findings of the meta-analysis suggest that breast cancer risk in premenopausal women may vary with respect to molecular subtypes. Extensive scientific work is still necessary in order to understand the impact of OCs use on breast cancer risk in young women.
Structure, Function, and Applications of Soybean Calcium Transporters
Authors: Jia Bowei , Li Yuan , Sun Xiaoli , Sun Mingzhe
Published: November 2022

Glycine max is a calcium-loving crop. The external application of calcium fertilizer is beneficial to the increase of soybean yield. Indeed, calcium is a vital nutrient in plant growth and development. As a core metal ion in signaling transduction, calcium content is maintained in dynamic balance under normal circumstances. Now, eight transporters were found to control the uptake and efflux of calcium. Though these calcium transporters have been identified through genome-wide analysis, only a few of them were functionally verified. Therefore, in this study, we summarized the current knowledge of soybean calcium transporters in structural features, expression characteristics, roles in stress response, and prospects. The above results will be helpful in understanding the function of cellular calcium transport and provide a theoretical basis for elevating soybean yield.
Triggers of Guillain–Barré Syndrome: Campylobacter jejuni Predominates
Authors: Finsterer Josef
Published: November 2022

Guillain–Barré syndrome (GBS) is a rare immune-mediated acute polyradiculo-neuropathy that typically develops after a previous gastrointestinal or respiratory infection. This narrative overview aims to summarise and discuss current knowledge and previous evidence regarding triggers and pathophysiology of GBS. A systematic search of the literature was carried out using suitable search terms. The most common subtypes of GBS are acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). The most common triggers of GBS, in three quarters of cases, are previous infections. The most common infectious agents that cause GBS include Campylobacter jejuni (C. jejuni), Mycoplasma pneumoniae, and cytomegalovirus. C. jejuni is responsible for about a third of GBS cases. GBS due to C. jejuni is usually more severe than that due to other causes. Clinical presentation of GBS is highly dependent on the structure of pathogenic lipo-oligosaccharides (LOS) that trigger the innate immune system via Toll-like-receptor (TLR)-4 signalling. AIDP is due to demyelination, whereas in AMAN, structures of the axolemma are affected in the nodal or inter-nodal space. In conclusion, GBS is a neuro-immunological disorder caused by autoantibodies against components of the myelin sheath or axolemma. Molecular mimicry between surface structures of pathogens and components of myelin or the axon is one scenario that may explain the pathophysiology of GBS.
Consequences of the Reproductive Effort of Dioecious Taxus baccata L. Females in a Generative Bud Removal Experiment—Important Role of Nitrogen in Female Reproduction
Authors: Rabska Mariola , Giertych Marian J. , Nowak Kinga , Pers-Kamczyc Emilia , Iszkuło Grzegorz
Published: November 2022

Dioecious species differ in the pattern and intensity of male and female reproductive investments. We aimed to determine whether female shoots deprived of generative buds show biochemical features, indicating their less-pronounced reproductive effort. For this purpose, the same branches of mature Taxus baccata females were deprived of generative organs. In the second and third years of the experiment, measurements were made in every season from the control and bud-removed shoots of females and control males. Bud removal caused an increase in nitrogen concentration almost to the level detected in the needles of male specimens, but only in current-year needles. Moreover, differences between male and control female shoots were present in the C:N ratio and increment biomass, but they disappeared when bud removal was applied to females. Additionally, between-sex differences were observed for content of phenolic compounds, carbon and starch, and SLA, independent of the female shoot reproductive effort. The study revealed that nitrogen uptake in seeds and arils may explain the lower nitrogen level and consequently the lower growth rate of females compared to males. At the same time, reproduction did not disturb carbon level in adjacent tissues, and two hypotheses explaining this phenomenon have been put forward.
Insights into the Biocompatibility and Biological Potential of a Chitosan Nanoencapsulated Textile Dye
Authors: Costa Eduardo M. , Silva Sara , Tavaria Freni K. , Pintado Manuela
Published: November 2022

Traditionally synthetic textile dyes are hazardous and toxic compounds devoid of any biological activity. As nanoencapsulation of yellow everzol textile dye with chitosan has been shown to produce biocompatible nanoparticles which were still capable of dyeing textiles, this work aims to further characterize the biocompatibility of yellow everzol nanoparticles (NPs) and to ascertain if the produced nanoencapsulated dyes possess any biological activity against various skin pathogens in vitro assays and in a cell infection model. The results showed that the NPs had no deleterious effects on the HaCat cells’ metabolism and cell wall, contrary to the high toxicity of the dye. The biological activity evaluation showed that NPs had a significant antimicrobial activity, with low MICs (0.5–2 mg/mL) and MBCs (1–3 mg/mL) being registered. Additionally, NPs inhibited biofilm formation of all tested microorganisms (inhibitions between 30 and 87%) and biofilm quorum sensing. Lastly, the dye NPs were effective in managing MRSA infection of HaCat cells as they significantly reduced intracellular and extracellular bacterial counts.
In Vitro Study of the Therapeutic Potential of Brown Crude Fucoidans in Osteoarthritis Treatment
Authors: Vaamonde-García Carlos , Capelo-Mera Emma , Flórez-Fernández Noelia , Torres María Dolores , Rivas-Murias Beatriz , Mejide-Faílde Rosa , Blanco Francisco J. , Domínguez Herminia
Published: November 2022

Osteoarthritis, one of the most common joint degenerative pathologies, still has no cure, and current treatments, such as nonsteroidal anti-inflammatory drugs, can cause serious adverse effects when taken for a long time. Brown seaweed crude fucoidans are used for the clinical treatment of several pathologies. In this study, the therapeutical potential of these biocompounds was analyzed in primary chondrocytes and the 260TT human chondrocyte cell line. Crude fucoidan from Undaria pinnatifida (Up) and Sargassum muticum (Sm) was obtained by different extraction techniques (microwave-assisted extraction, pressurized hot-water extraction, ultrasound-assisted extraction) and chemically and structurally characterized by Fourier transform infrared spectroscopy, high-performance size-exclusion chromatography, proton nuclear magnetic resonance, and scanning electron microscopy. Once cell viability was confirmed in chondrocytes treated with crude fucoidans, we evaluated their anti-inflammatory effects, observing a significant reduction in IL-6 production stimulated by IL-1β. Findings were confirmed by analysis of IL-6 and IL-8 gene expression, although only fucoidans from Up achieved a statistically significant reduction. Besides this, the antioxidant capacity of crude fucoidans was observed through the upregulation of Nrf-2 levels and the expression of its transcriptional target genes HO-1 and SOD-2, with compounds from Up again showing a more consistent effect. However, no evidence was found that crude fucoidans modulate senescence, as they failed to reduced β-galactosidase activity, cell proliferation, or IL-6 production in chondrocytes stimulated with etoposide. Thus, the findings of this research seem to indicate that the tested crude fucoidans are capable of partially alleviating OA-associated inflammation and oxidative stress, but fail to attenuate chondrocyte senescence.
Elevated Serum Amyloid A Levels Contribute to Increased Platelet Adhesion in COVID-19 Patients
Authors: Siman-Tov Ronen , Shalabi Rulla , Shlomai Amir , Goldberg Elad , Essa Wesam , Shusterman Eden , Ablin Jacob N. , Caspi Michal , Rosin-Arbesfeld Rina , Sklan Ella H.
Published: November 2022

Coronavirus disease-19 (COVID-19) patients are prone to thrombotic complications that may increase morbidity and mortality. These complications are thought to be driven by endothelial activation and tissue damage promoted by the systemic hyperinflammation associated with COVID-19. However, the exact mechanisms contributing to these complications are still unknown. To identify additional mechanisms contributing to the aberrant clotting observed in COVID-19 patients, we analyzed platelets from COVID-19 patients compared to those from controls using mass spectrometry. We identified increased serum amyloid A (SAA) levels, an acute-phase protein, on COVID-19 patients’ platelets. In addition, using an in vitro adhesion assay, we showed that healthy platelets adhered more strongly to wells coated with COVID-19 patient serum than to wells coated with control serum. Furthermore, inhibitors of integrin aIIbβ3 receptors, a mediator of platelet–SAA binding, reduced platelet adhesion to recombinant SAA and to wells coated with COVID-19 patient serum. Our results suggest that SAA may contribute to the increased platelet adhesion observed in serum from COVID-19 patients. Thus, reducing SAA levels by decreasing inflammation or inhibiting SAA platelet-binding activity might be a valid approach to abrogate COVID-19-associated thrombotic complications.