bluuebunny/crossref_metadata_2025 huggingface dataset:
Infantile Prognosis of Neonates Conceived by Assisted Reproductive Techniques: A prospective Study
Authors: Khoei Ellieh , Afjeh Seyyed Abolfazl , Tajalli Saleheh , Fallahi Minoo
Published: June 2020

Introduction: Outcomes of neonates of infertile couples that are golden babies and care of them is an issue of importance. But it is not yet clear if the prognosis is different between them and neonates from fertile couples. The purpose of this study was to determine the outcome of neonates conceived by assisted reproductive techniques.Methods: In this cohort study, a total of 165 newborn who were conceived by assisted reproductive techniques (ART) and 165 naturally concieved newborns were enrolled. The study was prospective from April 2017 to October 2019. All newborns were examined by neonatologist after birth and their outcome were followed up to two year. The outcomes were compared with neonates from fertile couple using appropriate statistical tests.Results: The preterm neonates (60% vs. 38%) were higher in ART cases (P<0.001). The mean gravid and parity were lower in ART group (P<0.001) and the nulliparity was higher in them. Multiple pregnancies were higher in ART cases (45% vs. 10%; P<0. 001). Cesarean section rate was higher (91% vs 67%) in ART cases (P<0.001). Pre-eclampsia rate was higher in ART cases (16 % vs. 6%; P=0.004). Female sex was higher in ART group (P=0.035). Birth weight was significantly lower in ART group (P=0.002) and the Apgar was also lower (P=0.002; P=0.012). Intrauterine growth restriction was significantly higher (17% vs. 7%) in ART group (P=0.006). Necrotizing enterocolitis and respiratory distress syndrome were more common in ART group (P<0.001). Hospital stay was longer in ART group (P<0.001). Re-admission, and weight less than 5th percentile were more common after two year in ART group (P=0.021).Conclusion: According to the obtained results, pregnancy after ART has more side effects before and after birth and also in infancy; not only because of multigestation but also due to manipulations in ART.
Is hydroxychloroquine with macrolide a good combination in COVID-19 compared to hydroxychloroquine alone from cardiac perspective? A systematic review and meta-analysis
Authors: Khadka Sitaram , Budhathoki Pravash , Shrestha Dhan Bahadur , Rawal Era
Published: June 2020

Background: The global spread of COVID-19 and the lack of definite treatment has caused an alarming crisis in the world. Hydroxychloroquine (HCQ) and azithromycin (AZT) are considered a possible treatment option. We aimed to evaluate the outcome and potential harmful cardiac effects of AZT+HCQ compared to HCQ alone for COVID-19 treatment.Methods: Pubmed, Medline, Google Scholar, Cochrane Library, and clinicaltrials.gov were searched using appropriate keywords and identified six studies using PRISMA guidelines. The quantitative synthesis was performed using fixed and random effects for the pooling of studies. Result: In this systematic review and meta-analysis, the risk of mortality (RR 1.16; 0.92-1.46) and adverse cardiac events (OR 1.06; 0.82-1.37) demonstrated a small increment though of no significance. There are no increased odds of mechanical ventilation (OR 0.84; 0.33-2.15) and significant QTc prolongation (OR 0.84, 0.59-1.21). Neither the critical QTc threshold (OR 1.92, CI 0.81-4.56) nor absolute ΔQTc ≥60ms (OR 1.95, CI 0.55-6.96) is increased to the level of statistical significance among HCQ+AZT arm compared to HCQ alone; but its slightly increased odds need to be considered in clinical practice. Conclusion: The combination of AZT+HCQ leads to small increased odds of mortality and cardiac events compared to HCQ alone. It is of no statistical significance for the critical QTc threshold and absolute ΔQTc ≥60ms, but increased odds with HCQ+AZT arm need to be considered in clinical relevance. Our result does not guide against the use of combination or HCQ alone based on the present level of evidence.
Recovery of moderate COVID-19 disease in a liver transplant recipient on continued immunosuppression
Authors: Mathiasen Victor Dahl , Karlsen Stine , Ott Peter , Jensen-Fangel Søren , Leth Steffen
Published: June 2020

BackgroundThe global outbreak of severe acute respiratory syndrome coronavirus 2 has had an enormous impact on the world. It remains unclear to what extent liver transplant recipients should be considered at a higher risk of severe disease due to the limited data available.Case presentationWe describe a moderate course of COVID-19 in a patient who underwent a liver transplant two years earlier due to Budd-Chiari syndrome. She presented with malaise, headache, dry cough and fever for four days. Immunosuppressive therapy with tacrolimus and mycophenolate mofetil was continued throughout the course of infection, oxygen therapy was given for a single night and the patient gradually recovered with supportive care only.ConclusionsWith this case report, we demonstrate that liver transplantation and immunosuppression is not necessarily associated with severe COVID-19 disease and emphasize that more information on this matter is urgently required. Withdrawal of immunosuppressive therapy could be associated with a higher mortality.
What to propose to treat post-viral non-conductive smell disorder in COVID-19? - systematic review with meta-analysis
Authors: Costa Klinger Vagner Teixeira da , Carnaúba Aline Tenório Lins , Rocha Katianne Wanderley , Andrade Kelly Cristina Lyra de , Menezes Pedro de L.
Published: June 2020

ObjectiveTo conduct a systematic review with meta-analysis on the treatments for post-viral non-conductive olfactory disorder (NCSD) to be proposed for olfactory disorder in COVID-19.Study designSystematic review and meta-analysis with searches between June 10th and 13th, 2020 in the databases: Medline via PubMed, Cochrane Clinical Trials, ScienceDirect, Lilacs, Scopus, Google Schoolar and Web of Science and gray literature. Inclusion criteria: (1) clinical trials with NCSD; (2) olfactory assessment before and after the intervention using a validated method; exclusion criteria: (1) NCSD from neurological causes; (2) studies unrelated to NCSD treatment; (3) duplicate publications. The quality of the studies was assessed by two independent researchers according to the Cochrane Collaboration recommendations.ResultsA total of thirteen clinical trials met the criteria: nine on drug treatments and four on olfactory training with four odors. In drug treatments, caroverine, vitamin A, insulin, pentoxifylline, alpha-lipoic acid and sodium citrate were evaluated. The meta-analysis (336 patients) identified, through the random effect analysis, a statistically significant improvement between the TDI score before and after the olfactory training was observed (SMD = 5.18; 95% confidence interval (CI) [4.12, 6.23], p<0.00001).ConclusionSodium citrate and olfactory training are therapeutic approaches to recover olfactory function in post-viral NCSD and can be considered considered for NCSD due to COVID-19; however, further clinical trials are needed to confirm the results evaluated and establish treatment protocols.
PERFIL BIOQUÍMICO E NUTRICIONAL DE VEGETARIANOS E ONÍVOROS DE UM MUNICÍPIO DE SANTA CATARINA, BRASIL
Authors: Damázio Louyse Sulzbach , Grassi Raquel Genuino Teixeira , Mattos Tuany Cardoso , Celso Danielle , De Souza Emanuel , Schultze Eduarda , Bongiolo Ângela Martinha
Published: June 2020

O objetivo foi avaliar marcadores bioquímicos e nutricionais e a associação com a composição corporal de vegetarianos e onívoros do município de Criciúma - SC. Foram avaliados: parâmetros plasmáticos, níveis séricos de vitamina B12 (nos vegetarianos), índice de massa corporal, circunferência da cintura, composição corporal, motivos para a dieta vegetariana e tempo de vegetarianismo e questionário socioeconômico. Participaram da amostra 34 indivíduos adultos, sendo 11 ovolactovegetarianos, 11 veganos e 12 onívoros, com idade média de 25,24 anos e predominância do gênero feminino. Na classificação do estado nutricional, 97% dos avaliados apresentou IMC eutrófico. A circunferência da cintura esteve adequada nos ovolactovegetarianos (90,9%), veganos (81,8%) e com risco moderado nos onívoros (33,3%). Verificou-se que entre os ovolactovegetarianos (27,3%) e veganos (18,2%) houve excesso de gordura corporal e percentil de massa magra (AMB) muito baixo (36,4%). O colesterol total estava normal em 100% dos ovolactovegetarianos, 81,8% dos veganos e nos onívoros apresentou-se alto em 58,3%. Na glicemia, 50% dos onívoros estavam com risco aumentado para diabetes, enquanto 100% dos ovolactovegetarianos e 81,8% veganos apresentaram normoglicemia. Ocorreu maior predominância de indivíduos onívoros (41,66%) com hemoglobina abaixo do ideal e indicativo de anemia, contra 27,3% nos vegetarianos. Já os níveis séricos de vitamina B12 nos vegetarianos apresentaram-se dentro dos valores ideais, com uma média em 362,86pg/ml. Concluímos que os vegetarianos apresentam melhor perfil lipídico e glicêmico, quando comparados aos onívoros.
PRÁTICAS E ESTÁGIOS DE ODONTOLOGIA COMO ESTRATÉGIAS DE MUDANÇAS PARA FORMAÇÃO NO SUS
Authors: Moraes Bibiana Arantes , Cassiano Cenise Cristina Zago , Costa Nilce Maria da Silva Campos
Published: June 2020

Este estudo buscou analisar as atividades desenvolvidas nos estágios e práticas do curso de graduação em Odontologia de uma instituição pública federal de ensino superior, inserido nos programas Pró- Saúde (Programa Nacional da Formação em Saúde) e PET-Saúde (Programa de Educação pelo Trabalho para a Saúde). Foram analisados o Estágio de Odontologia Coletiva II e o Estágio não curricular do PET-Saúde/Rede de Atenção à Saúde, por meio da descrição das atividades de formação profissional, vivenciadas no Sistema Único de Saúde (SUS), sob a perspectiva do preceptor. Realizou-se um estudo de abordagem qualitativa e triangulação de dados, por meio, da análise documental do projeto político pedagógico do curso e do guia do estágio, a observação participante no campo de estágio e análise de conteúdo das entrevistas semiestruturadas com preceptores dos estágios. Os resultados demonstraram o predomínio da formação orientada pelas Diretrizes Curriculares Nacionais (DCN) e a contribuição dos programas citados na integração ensino-serviço-comunidade, favorecendo a implementação das DCN nos cenários de prática. A interprofissionalidade, entretanto, encontra-se incipiente, sendo observada a falta de clareza e de disposição dos atores envolvidos para desenvolvê-la. A pesquisa indicou que a realização dos estágios trouxe aos estudantes, oportunidades de aprendizagem, reflexão e compreensão do SUS.
RECURSOS TERAPÊUTICOS PARA A FIBROMIALGIA: UMA REVISÃO SISTEMÁTICA
Authors: Melo Géssika Araújo de , Araújo Gilvane De Lima , Vasconcelos Aline Miranda de , Torro Nelson
Published: June 2020

A Fibromialgia (FM) é caracterizada como uma síndrome altamente prevalente e incapacitante, que afeta principalmente mulheres com faixa etária entre 20 e 55 anos. Atualmente não há cura para FM, portanto seu tratamento visa reduzir os sintomas, principalmente de dor, e melhorar a qualidade de vida e funcionalidade do indivíduo. Os tratamentos farmacológicos não têm sido eficazes nessa população, portanto, emerge a necessidade de terapêuticas complementares na FM. Assim, o presente estudo objetivou analisar o estado da arte acerca dos recursos terapêuticos não farmacológicos utilizados para o quadro clínico da FM. Trata-se de uma revisão sistemática da literatura, na qual se utilizaram as bases de dados da PubMed, Psycinfo, ScienceDirect, LILACS e SciELO. Após aplicação dos critérios de elegibilidade, permaneceram 18 artigos. O interesse em estudos acerca dos recursos terapêuticos utilizados na FM tem sido crescente, concentrando-se nos dois últimos anos. As possibilidades terapêuticas mais estudadas nos últimos cinco anos foram os exercícios resistidos e aeróbicos, a hidroterapia, a cinesioterapia e a neuromodulação. Ressalta-se que as características individuais devem ser levadas em consideração para escolha do tratamento, devido à heterogeneidade dos sintomas que podem estar presentes em cada paciente. Por fim, sugere-se que o acompanhamento destes indivíduos seja multiprofissional devido ao quadro clínico da FM ser multifatorial.
CONTRIBUIÇÃO DA FISIOTERAPIA SEGUNDO MÉDICOS E ENFERMEIROS DAS UNIDADES BÁSICAS DE SAÚDE DA FAMÍLIA
Authors: Zarili Thais Fernanda Tortorelli , Dias Maria Dionísia do Amaral
Published: June 2020

O objetivo do trabalho consiste em identificar os principais obstáculos no processo de trabalho das equipes de Atenção Primária à Saúde (APS) e a contribuição das ações e serviços de Fisioterapia para o cuidado integral dos usuários, segundo a percepção de médicos e enfermeiros da Estratégia de Saúde da Família de Botucatu (SP). Estudo descritivo, com abordagem qualitativa utilizou questionário semiestruturado. As respostas dicotômicas foram analisadas segundo a frequência e as respostas abertas segundo análise temática. Participaram da pesquisa 28 profissionais, na maioria do sexo feminino. Os resultados demonstram a sobrecarga de trabalho pelo excesso de demanda e dificuldades com relação ao próprio serviço, à  equipe e à gestão municipal, evidenciou que tais profissionais possuem conhecimento quanto à atuação da Fisioterapia e que há diversas demandas que necessitam do apoio matricial do fisioterapeuta ou de encaminhamentos aos serviços especializados de Fisioterapia, assim como compreendem a contribuição para a resolutividade dos casos atendidos no serviço e a melhoria da qualidade de vida do paciente. A inserção do fisioterapeuta corrobora com a clínica ampliada enquanto ferramenta para o cuidado e o fortalecimento das suas ações deve estar em consonância com as necessidades do território e articuladas com a equipe do serviço.
ADHERENCE, ADVERSE DRUG REACTION AND EFFECTIVENESS OF THE HEPATITIS C CHRONIC TREATMENT
Authors: Schwambach Karin , Blatt Carine Raquel
Published: June 2020

Objective: To assess adherence, adverse drug reaction and Sustained Virological Response (SVR) in the therapy for hepatitis C. This follow-up retrospective observational study was conducted in a specialized center for hepatitis treatment in Southern Brazil. Methods: This research included 257 patients under hepatitis C treatment with all‐oral direct‐acting antivirals  in a clinical setting from March to August 2016. The data was obtained from medical records. Adherence was measured by medicines refill and Medication Possession Ratio. Results: Of the 253 patients evaluated, 8,7% had some problem with adherence to the treatment. No cases of treatment discontinuation due to adverse drug reaction was observed.  However, 1433 adverse drug reactions were identified and classified as mild, with an average of 5,6 per patient. The most frequent reactions were headache (55,7%), asthenia (47,3%), altered appetite (41,9%), dry skin (37,2%), and nausea/vomiting (35,9%). The overall SVR rate was 90,9%. Other outcomes were no response to treatment (2,0%), relapsed (2,0%), dead (0,4%), dropout (0,4%) and lost to follow-up (4,3%). In the multivariate analysis, hepatitis C virus and  human immunodeficiency virus co-infection and longer treatment time were associated with higher SVR (p = 0,028 and p = 0,020, respectively). Conclusion: The treatments evaluated have high response rate and were well tolerated by the patients. Adherence to treatment proved to be adequate and contributed to the results. The care offered in a specialized center provides the appropriate management of the patients’ needs, contributing thus to a successful therapy.
AVALIAÇÃO DA QUALIDADE DE COMPRIMIDOS DISPENSADOS EM UMA FARMÁCIA PÚBLICA DO NOROESTE DO RIO GRANDE DO SUL
Authors: Krauser Débora Cristina , Horn Roberta Cattaneo , Bonfanti-Azzolin Gabriela , Norbert Deuschle Regis Augusto , Kessler Nunes Deuschle Viviane Cecilia
Published: June 2020

O controle de qualidade é um processo importante após o preparo de medicamentos e deve abranger todas as etapas da produção. Desvios na qualidade de um medicamento podem causar diversos danos à saúde do paciente. O Sistema Único de Saúde (SUS) conta com distribuição gratuita de medicamentos para a população e a aquisição desses medicamentos é feita através de licitações. Nesse sentido, o objetivo deste trabalho foi realizar testes físico-químicos de controle de qualidade de comprimidos dispensados em uma Farmácia Pública de um município do noroeste do Rio Grande do Sul. Foram fornecidos pela Farmácia Pública, os seguintes medicamentos: furosemida 40 mg, enalapril de 10 mg e propranolol 40 mg. Os testes realizados foram: análise do aspecto físico, peso médio, friabilidade, tempo de desintegração e doseamento. A furosemida foi reprovada no teste do peso médio e aprovada nos demais testes. Já o propranolol foi reprovado no ensaio de doseamento, encontrando-se abaixo das especificações. O enalapril apresentou conformidade em todos os testes realizados. Esses resultados demonstram que os medicamentos podem comprometer a saúde do usuário do Sistema público e que esses requisitos podem ser utilizados para qualificar os fornecedores que participam dos processos licitatórios.
THE WAY THE LOCAL GOVERNMENT WORKS TO FIGHT AGAINST CORRUPTION IN KUPANG CITY IN THE PERSPECTIVES OF GENERATIONS X AND Y
Authors: Thoomaszen Friandry Windisany , Tameon Sance Mariana
Published: June 2020

Generations Y and Z are the next generations of the Indonesian nation, including in the process of preventing and eradicating corruption. These two generations tend to have the same weaknesses, that is, the tendency to be apathetic towards the government and politics. This apathy can be an obstacle to eradicating corruption cases in the future when these generations occupy strategic positions. The aim of the study is to find out the views of generations Y and Z on the way the local government works to eradicate corruption cases in Kupang City. The researchers use a quantitative approach, with descriptive survey research methods. The research subjects are 78 Christians from the generation Y and Z who live in Kupang City. The sampling technique used is stratified random sampling which is spread using the google forms (online) format. The results of the study show that generation Y and Z are sensitive to cases of corruption that are taking place in their domicile, Kupang City. Out of 78 subjects of generation Y and Z, the majority or  42 subjects answer that the level of corruption in Kupang City is at a severe level. Generation Z also looks more familiar with Nine anti-corruption values than generation Y. There are various solutions offered by generations Y and Z for regional leaders to overcome corruption in Kupang City. However, the solution to the campaign is still considered to be less effective in dealing with corruption for generation Y and Z. It is recommended that local governments see and use the opinions of generation Y and Z to improve themselves and the anti-corruption system and involve generation Y and Z to prevent, fight, and eradicate corruption cases actively both in real actions and in cyberspace (social media). Anti-corruption behavior conveyed to generations Y and Z must be more attractive, modern, and in accordance with the characteristics of these two generations who have a dependency on cyberspace.
Analisis Textbooks-for-High-School-Student- Studying-the Sciences-Chemistry materi Pokok Hidrokarbon dalam Perspektif Kurikulum 2013
Authors: Rizqiana Fika Atina , Siddiq Mahfudz , Rahmawati Atik
Published: June 2020

Penelitian ini bertujuan untuk mengetahui sajian materi hidrokarbon (kelengkapan materi, akurasi, pemecahan masalah, komunikasi, koneksi, dan penyampaian) pada bahan ajar Textbooks For High School Students Studying The Sciences Chemistry yang diterbitkan oleh FHSST Author Afrika Selatan serta relevansinya dengan kurikulum 2013 untuk SMA Kelas X. Penelitian dilakukan dengan menggunakan metode analisis dokumen (documentary analysis) atau analisis isi (content analysis). Teknik pengumpulan data yang digunakan yaitu dokumentasi dan wawancara. Hasil penelitian menunjukkan bahwa aspek kelengkapan materi 62,5% (cukup); akurasi 58,3% (kurang); pemecahan masalah sebesar 75% (baik); komunikasi 62,5% (cukup); koneksi (keterkaitan) 50% (kurang); penyampaian (represent) 62,5% (cukup). Adapun relevansi materi hidrokarbon pada Textbooks For High School Students Studying The Sciences Chemistry dengan kurikulum 2013 adalah sebesar 31,2 % (sangat kurang). Berdasarkan hasil penelitian, dapat diketahui bahwa materi pokok hidrokarbon pada Textbooks For High School Students Studying The Sciences Chemistry terbitan FHSST Authors dari Afrika Selatan tidak memenuhi dari segi isi materi, relevansi dengan kurikulum, dan pembahasannya belum lengkap untuk pembelajaran di SMA kelas X. 
Efektivitas Penggunaan Multimedia Pembelajaran berbasis Multi Level Representasi (MLR) untuk meningkatkan Hasil Belajar Peserta Didik pada Materi Sistem Koloid Kelas XI MAN Kendal
Authors: Dwi Astuti Indah , Mulyatun Mulyatun
Published: June 2020

Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan pembelajaran multimedia berbasis MLR pada materi sistem koloid. Penelitian yang dilakukan adalah penelitian eksperimen dengan bentuk Pretest-posstest Control Group Design dengan pengambilan sampel dalam kelompok cluster random sampling. Nilai rata-rata hasil belajar yang diperoleh dari kelas eksperimen dan kelas kontrol berturut-turut adalah 74,85 dengan persentase ketuntasan 71% dan 65,97 dengan persentase ketuntasan 33%. Berdasarkan hasil uji t-test pada = 5% dan dk = 56 diperoleh thitung> ttabel = 4,475> 2,003, sehingga dapat disimpulkan bahwa terdapat perbedaan rata-rata hasil belajar antara kelas eksperimen dan kontrol. Selanjutnya dari hasil analisis sisi kanan, diperoleh thitung> ttabel = 4,475> 1,672 dengan dk = 57 dan pada = 5%. Hasil penelitian ini dapat disimpulkan bahwa pembelajaran kimia menggunakan multimedia berbasis pembelajaran MLR pada materi koloid efektif diterapkan pada pembelajaran kimia, dan dapat meningkatkan hasil belajar siswa kelas XI MIPA di MAN Kendal.
Pengembangan Modul Kimia Socio-Scientific Issues (SSI) Materi Reaksi Reduksi Oksidasi
Authors: Sofiana Sofiana , Wibowo Teguh
Published: June 2020

Penelitian pengembangan ini dilatarbelakangi oleh kesulitan belajar pada materi reaksi reduksi oksidasi yang dialami peserta didik akibat terbatasnya jumlah bahan ajar yang dapat digunakan secara mandiri, kurangnya variasi bahan ajar yang digunakan guru, dan rendahnya motivasi belajar peserta didik karena menganggap mata pelajaran kimia adalah mata pelajaran yang sulit, dan  tidak berkaitan langsung dengan kehidupan, khususnya materi reaksi reduksi oksidasi. Hal ini ditunjukkan oleh adanya 58,9% peserta didik yang menyatakan materi reaksi reduksi oksidasi adalah materi yang sulit. Bahan ajar yang memberikan kesempatan bagi peserta didik untuk belajar menurut kecepatan masing-masing adalah modul. Tujuan penelitian ini adalah untuk menghasilkan modul yang memuat pembelajaran kontekstual dengan pendekatan socio-scientific issues (SSI). Model pengembangan yang digunakan dalam penelitian ini adalah model pengembangan ADDIE (Analyze, Design, Develop, Implement, Evaluate). Subjek penelitian pengembangan ini adalah 9 peserta didik kelas X MIA 2 MA Al-Irsyad Gajah. Hasil penilaian kualitas modul yang dilakukan oleh validator ahli materi diperoleh sebesar 84,60% dengan kategori sangat valid. Penilaian validator ahli media sebesar 91,00% dengan kategori sangat valid, dan respon peserta didik sebesar 80,69%. Sedangkan rata-rata skor untuk uji keterbacaan modul sebesar 68,88% dengan kategori keterbacaan tinggi. Hasil tersebut menunjukkan bahwa modul yang dikembangkan layak digunakan dan diimplementasikan pada kelas besar.
Peningkatan Hasil Belajar dan Keaktifan Belajar Kimia melalui Model Pembelajaran Disco Winshop
Authors: Lestari Sri
Published: June 2020

Penelitian Tindakan Kelas (PTK) ini bertujuan untuk mengetahui pengaruh penerapan model pembelajaran Disco Winshop terhadap peningkatan hasil belajar dan keaktifan peserta didik kelas X MIPA 2 pada materi Ikatan Kimia di SMA Negeri 1 Pamotan. Penelitian ini dilakukan pada 2 siklus, tiap siklus terdiri atas empat tahapan, yaitu perencanaan, tindakan, observasi dan refleksi. Subjek Penelitian adalah peserta didik kelas X MIPA 2 SMA Negeri 1 Pamotan yang berjumlah 35 orang yang terdiri dari 12 peserta didik laki-laki dan 23 peserta didik perempuan. Analisis data menggunakan Teknik deskriptif kuantitatif. Hasil penelitian menunjukkan adanya peningkatan hasil belajar dan keaktifan peserta didik pada materi ikatan kimia. Pada siklus I diperoleh skor rata-rata hasil belajar 64, ketuntasan klasikal 57%, dan aktivitas peserta didik 81,71%. Pada siklus II diperoleh skor rata-rata hasil belajar 85, ketuntasan klasikal 74%, dan aktivitas peserta didik 91,33%.
PENTINGNYA PERAN TUTOR DALAM PEMBELAJARAN DI DUMPIT
Authors: Purba Friska Juliana
Published: June 2020

Melihat kondisi anak-anak di wilayah Pos Dumpit dimana ada anak yang tidak dapat bersekolah, dan ditemukan juga kondisi anak-anak yang seharusnya sudah berada di level yang tinggi akan tetapi secara kemampuan masih berada di level yang rendah. Hal ini disebabkan karena keterbatasan perekonomian keluarga dimana mata pencaharian keluarga itu sebagian besar buruh serabutan, kuli cuci piring, dan pemulung. Hal inilah yang menyebabkan kondisi pendidikan mereka kurang layak dibandingkan dengan anak-anak yang memperoleh pendidikan di tempat lain. Untuk itu bimbingan belajar Pos Dumpit hadir dan bertujuan untuk (1) Meningkatkan kemampuan membaca, menulis, dan menghitung pada anak-anak dengan cara memberikan pembelajaran yang menarik dan menyenangkan pada anak TK dan SD, (2) Membantu anak-anak dalam memahami pelajaran yang sulit di sekolah, (3) Membantu anak-anak dalam menanamkan sikap berjuang melalui belajar yang giat, (4) Membantu anak-anak dalam meningkatkan kemampuan berpikir dan perubahan tingkah laku pada anak-anak menuju ke arah yang lebih baik. Bimbingan belajar ini menghadirkan tutor-tutor yang sudah diperlengkapi secara pedagogy maupun ilmu pengetahuan. Strategi pembelajaran yang dipergunakan tutor bervariasi, disesuaikan dengan kebutuhan dari tutee dan tingkatan. Dengan melihat kebutuhan tutee, maka tutor dapat meningkatkan motivasi dan keinginan belajar mereka. Harapannya bimbingan belajar ini tetap dapat bermanfaat bagi anak-anak, masyarakat, dan menjadi pembelajaran juga untuk tutor.

 

Kata kunci: Dumpit, bimbingan belajar, tutor
Investigation of influence of forced ventilation through 3D textile on heat exchange properties of the textile layer
Authors: Gadeikytė Aušra , Barauskas Rimantas
Published: June 2020

The intention of this study was to create a computational model in micro-scale that allows to imitate heat and mass transfer through three-dimensional textile layer with and without forced ventilation. The four ventilation rates were used 0, 0.2, 0.4 and 0.8 dm3min-1. Approximation of a unit cell geometry and heat transfer process were considered. The time-dependent and steady-state simulations are based on Navier-Stokes/Brinkman partial differential equations, and energy equation. A finite element modelling package Comsol Multiphysics was used for numerical simulations. The Laminar flow (.spf) and Heat transfer in fluids (.ht) modes were coupled with non-isothermal flow (.nitf) multi-physics. The post-processing analysis was done using Matlab software. The outcomes of simulation are temperature distributions, surface average temperature and relative humidity through the thickness of the representative volume. The results enable to create a macro-scale models for efficient simulation of heat exchange in textile packages.
Cancer Pro-oxidant Therapy Through Copper Redox Cycling: Repurposing Disulfiram and Tetrathiomolybdate
Authors: Rieber Manuel
Published: June 2020

Background:

Copper (Cu) is a transition metal active in Fenton redox cycling from reduced Cu+ and
H2O2, to oxidized Cu2+ and the hydroxyl radical (·OH) highly reactive oxygen species (ROS). At homeostatic Cu
levels, ROS promote cell proliferation, migration, angiogenesis, and wound repair. To limit ROS toxicity, cells
use Cu-dependent chaperone proteins, Cu-binding ceruloplasmin, and Cu-modulated enzymes like superoxide
dismutases (SOD) like SOD1 and SOD3 to scavenge excess superoxide anions which favour Cu+ reduction, and
mitochondrial cytochrome c oxidase, important in aerobic energy production. Because Cu helps drive tumor cell
proliferation by promoting growth factor-independent receptor tyrosine kinase signaling, and Cu-dependent
MEK1 involved in oncogenic BRAF-V600E signaling, further augmenting bioavailable Cu may promote ROS overproduction,
cancer progression and eventually tumor cell death. For these reasons, the following clinically approved
copper chelators are being repurposed as anti-cancer agents: a) ammonium tetrathiomolybdate (TTM)
used to treat Wilson’s disease (copper overload) and Menkes disease (copper deficiency); b) Disulfiram (DSF),
used against alcoholism, since it inhibits Aldehyde Dehydrogenase (ALDH1) enzyme, important in ethanol detoxification,
and a key target against cancer stem cells. Moreover, TTM and DSF are also relevant in cancer clinical
trials, because they increase the uptake of both Cu and Platinum (Pt)-containing anti-cancer drugs, since Pt
and Cu share the same CTR1 copper transporter.

Purpose:

The majority of reports on Cu chelators dealt separately with either TTM, DSF or others. Here, we
compare in parallel, the anti-cancer efficacy of low doses of TTM and DSF, asking whether they can be synergistic
or antagonistic. The relevance of their unequal ROS inducing abilities and their different behavior as ionophores
is also addressed.

Significance:

The potential of Cu chelators as repurposed anti-cancer drugs, should be greater in patients with
higher endogenous Cu levels. Since platinum and Cu share uptake receptors, the synergism by drugs containing
these metals should not be under-estimated. The potential of disulfiram or its metabolically active Cu-containing
form, to inhibit ALDH1-positive tumor cells is therapeutically very important.
Chemical Composition and Antibacterial Activities of Sumac Fruit (Rhus coriaria) Essential Oil on Dental Caries Pathogens
Authors: Moghadam Parisa , Dadelahi Shahram , Hajizadeh Yasamin S. , Matin Milad G. , Amini Milad , Hajazimian Saba
Published: June 2020

Introduction:

Dental caries is an infectious disease, and various microorganisms are involved in its progression. The common antibacterial agents against oral pathogens have many side effects and their excessive use cause drug resistance. Therefore, the identification of natural compounds and medicinal plants with antibacterial activity has been considered by the researchers. The Sumac (Rhus coriaria) is one of the native plants of Iran, which used as a food flavoring.

Aims & Objectives:

The aim of this study was to evaluate the antimicrobial activity of Sumac essential oil on oral pathogens, including Streptococcus mutans, Lactobacillus rhamnosus, and Actinomyces viscosus.

Materials & Methods:

In this study, the Sumac essential oil was prepared and its antibacterial activity was evaluated by disk diffusion, Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC) methods on established terminology strains of S. mutans, L. rhamnosus, and A. viscosus.

Results:

The obtained results showed that the Sumac essential oil has high inhibitory effects against S. mutans, followed by L. rhamnosus and A. viscosus. The predominant compound in the Sumac essential oil was related to Beta-caryophyllene.

Conclusion:

In conclusion, Sumac essential oil has an appropriate antibacterial activity and can be used in the pharmaceutical industry to produce antibacterial agents and mouthwash, against oral infectious diseases and dental caries.
Multi-collaborative Regression Convolutional Neural Network for Vehicle Angle Detection
Authors: Chen Guoqiang , Liu Mengchao , Zhou Hongpeng , Bai Bingxin
Published: June 2020

Background:

The vehicle pose detection plays an important role in monitoring vehicle
behavior and the parking situation. The real-time detection of vehicle pose with high accuracy is of
great importance.

Objective:

The goal of the work is to construct a new network to detect the vehicle angle based on
the regression Convolutional Neural Network (CNN). The main contribution is that several traditional
regression CNNs are combined as the Multi-Collaborative Regression CNN (MCR-CNN), which
greatly enhances the vehicle angle detection precision and eliminates the abnormal detection error.

Methods:

Two challenges with respect to the traditional regression CNN have been revealed in detecting
the vehicle pose angle. The first challenge is the detection failure resulting from the conversion
of the periodic angle to the linear angle, while the second is the big detection error if the training
sample value is very small. An MCR-CNN is proposed to solve the first challenge. And a 2-
stage method is proposed to solve the second challenge. The architecture of the MCR-CNN is designed
in detail. After the training and testing data sets are constructed, the MCR-CNN is trained
and tested for vehicle angle detection.

Results:

The experimental results show that the testing samples with the error below 4° account for
95% of the total testing samples based on the proposed MCR-CNN. The MCR-CNN has significant
advantages over the traditional vehicle pose detection method.

Conclusion:

The proposed MCR-CNN cannot only detect the vehicle angle in real-time, but also
has a very high detection accuracy and robustness. The proposed approach can be used for autonomous
vehicles and monitoring of the parking lot.
Lump in the Throat – an Algorithm for the Actions of a Physician
Authors: Orishchak Diana , Vasyliuk Nataliia , Orishchak Ostap
Published: June 2020

Diagnosis and treatment of patients with complaints of the “lump in the throat” remain a complex multidisciplinary problem. This is due to the polyetiology of factors causing similar symptoms and an empirical approach to the treatment. “Lump in the throat” is one of the clinical manifestations of upper respiratory tract paresthesia. According to the literature data, there is the reason for referral to an otolaryngologist in 4.1 to 5.0% of cases.

The objective of the research was to optimize and improve the diagnosis and pathogenetic approach to the “lump in the throat” treatment.

Materials and Methods. To achieve the specified objective, a comprehensive examination of 38 patients who sought an otolaryngologist’s medical advice, complaining of a “lump in the throat” at the age of 18-45 years (26 women and 12 men), was performed. For the purpose of optimal diagnostics, general clinical examination, examination of ENT organs, endoscopic examination of the nasal cavity and nasopharynx, microlaryngoscopy were performed; the condition of patients’ psycho-emotional status was assessed (consultation of psychologist and psychiatrist).

Results. A comprehensive clinical study of 38 patients with complaints of the “lump in the throat” at the age of 18-45 years was performed. Psychosomatic disorders were detected in 26 patients; ENT organ diseases were present in 12 patients. All patients received treatment depending on the diagnosed somatic, otorhinolaryngological and psychosomatic pathology.
Clinical evolution of Spitz nevi
Authors: Voloshynovych Marian , Rosendahl Cliff , Girnyk Galyna , Tsidylo Ivanna , Blaha Iryna
Published: June 2020

Nevus Spitz is a benign melanocytic proliferation, first described in 1948 by Sophie Spitz as a childhood melanoma. Initially, it was described as an erythematous papule or node, but further studies of the Spitz nevus proved that in 71-92% cases it is a pigmented formation. This pigmentation is often quite intense due to the rapid growth of the formation, which leads to the need for differential diagnosis with skin melanoma. After all, dermatoscopy can be used for this purpose and, when applying this research method, typically a pattern of an exploding star formed by streaks of linear pigmentation and symmetrically located pigment globules placed in the peripheral zone can be revealed. In case of non-pigmented Spitz nevus, spot vessels and reticular depigmentation are visualized. Both pigmented and non-pigmented forms of Spitz nevus in the process of evolution can regress partially or completely. Several clinical cases of different types of spitzoids, both typical and atypical, based on the non-clinical, dermatoscopic and histological diversity of the Spitz nevi, have been demonstrated in the article. Their macroscopic and dermatoscopic features as well as probable signs of dynamic changes are indicated in order to facilitate their recognition by other specialists.
Characteristics of Puberty Period in Adolescent Girls and Major Risk Factors of Menstrual Function Disorders Against the Background of Endemic Goiter
Authors: Hafiichuk Svitlana
Published: June 2020

Disorders of menstrual function are often the result of thyroid dysfunction and disorders of the neuroendocrine regulation, initiated by iodine deficiency, and are the most destructive in puberty period.

The objective of the study was to clarify the peculiarities of establishment of menstrual function and the degree of interaction between the hypothalamic-pituitary-ovarian system and thyroid gland against the background of iodine deficiency in adolescence.

Materials and methods of research. Analytical analysis of medical records and sociomedical audit were carried out by interviewing 490 girls of puberty age, the purpose of which was to estimate the prevalence of thyroid dysfunction and possible factors of development of menstrual disorders.

Results of the study and their discussion. The proportion of thyroid dysfunction in adolescent girls is quite significant; hypofunction was diagnosed 3.4 times more frequent than its increased activity. Less than half of the studied had regular menstrual cycle, while girls with thyroid dysfunction suffered much more often from menstrual dysfunction in the form of hypomenstrual syndrome (1.5-fold, p<0.05), algodismenorrhea (1.6-fold, p<0.05) and amenorrhea (1.4-fold, p<0.05), premenstrual syndrome and anovulatory conditions associated with polycystic ovary syndrome. Such somatic diseases as neuro-vegetative dysfunction, diseases of the gastrointestinal tract, chronic tonsillitis, frequent lacunar angina and acute respiratory viral diseases are common. Clinical manifestations included symptoms of thyroid hypofunction, androgen-associated dermopathy, hirsutism syndrome, and concomitant endocrine-associated pathology of the mammary glands (mastalgia, mastopathy, and galactorrhea).

Conclusions. The burden of perinatal history, the presence of thyroid pathology and other manifestations of metabolic and endocrine disorders in first-degree relatives are unfavourable prognostic factors of disorders of the menstrual cycle against the background of thyroid dysfunction. The findings obtained allow us to determine the leading risk factors for problematic menstruation establishment and menstrual disorders, especially when combined with thyroid dysfunction. Hypomenstrual syndrome and algodysmenorrhea, as well as manifestations of premenstrual syndrome and anovulatory cycles, belong to major disorders of the menstrual cycle in case of thyroid gland dysfunction.
Distância diacrónica automática entre variantes diatópicas do português e do espanhol
Authors: Pichel José Ramom , Gamallo Pablo , Neves Marco , Alegria Iñaki
Published: June 2020

O objetivo deste trabalho é aplicar uma metodologia baseada na perplexidade, para calcular automaticamente a distância interlinguística entre diferentes períodos históricos de variantes diatópicas de idiomas. Esta metodologia aplica-se a um corpus construído adhoc em ortografia original, numa base equilibrada de ficção e não-ficção, que mede a distância histórica entre o português europeu e do Brasil, por um lado, e o espanhol europeu e o da Argentina, por outro. Os resultados mostram distâncias muito próximas em ortografia original e transcrita automaticamente, entre as variedades diatópicas do português e do espanhol, com ligeiras convergências/divergências desde meados do século XX até hoje. É de salientar que o método não é supervisionado e pode ser aplicado a outras variedades diatópicas de línguas.
A pintura artística em espaços urbanos tombados no Brasil: limites e possibilidades
Authors: Dantas Fabiana Santos
Published: June 2020

As cidades nascem para possibilitar a convivência das pessoas e o compartilhamento

de sua vida cotidiana. Como habitat, são palcos para manifestações as mais variadas, inclusive

artísticas, reveladas por suas formas arquitetônicas, pelos estilos de vida, e pela percepção e

atitudes ambientais daqueles que nelas habitam. Algumas cidades tornam-se monumentos e

frações do seu espaço, passam a ser regidas por normas especiais e diferenciadas, mais restritivas.

O tombamento estabelece um regime diferenciado de exercício do direito de propriedade,

com obrigações para proprietários e vizinhos, que o tornam um espaço de exceção. Neste artigo

discute-se como compatibilizar as manifestações artísticas, em especial a pintura em imóveis

tombados, com o objetivo de pontuar as principais questões e estabelecer delineamento legal

das normas de preservação sobre a matéria. O resultado esperado é contribuir para uma melhor

compreensão do tema através de um panorama e da contextualização da discussão, bem como

de documentos legislativos e bibliografia pertinente, com foco na compreensão dos limites para

a atuação da fiscalização pela Administração Pública brasileira na compatibilização entre a preservação

de bens culturais e a efetivação da democracia e exercício de direitos culturais. A metodologia

de pesquisa consistiu em pesquisa bibliográfica, realizada através da análise de livros,

artigos científicos, de revista e pesquisa documental quanto à legislação específica.
Aplicações móveis para o turismo cultural: Caminhos de Santiago
Authors: Mazeda Miguel , Teixeira Luís
Published: June 2020

Este artigo apresenta o resultado do estudo sobre as aplicações móveis na área do Turismo
Cultural para os Caminhos de Santiago. Este estudo foi desenvolvido no âmbito da atividade
B2 “Gestão de conteúdos pertencentes ao património cultural nacional baseado em sistemas
abertos de preservação e interação” do projeto CHIC – “Cooperative Holistic View on Internet
and Content” (POCI-01-0247-FEDER-024498). A atividade B2 tem como objetivo conceber e implementar
uma plataforma para o desenvolvimento de aplicações móveis, que suporte conteúdos
de média avançados como realidade aumentada, vídeo 360º e dados georreferenciados,
tendo sido selecionada como prova de conceito o desenvolvimento de uma aplicação para os
Caminhos de Santiago. Neste artigo são apresentadas e analisadas as principais caraterísticas
das aplicações móveis existentes para os Caminhos de Santiago.
A arte pública entre património e ideário. O itinerário artístico de Siah Armajani
Authors: Abreu José
Published: June 2020

Siah Armajani (1939-) é um escultor de origem iraniana que ainda muito jovem emigrou

para os EUA, onde empreendeu uma carreira artística, sediada em Minneapolis, no Minnesota.

Para além de autor de uma vasta e reconhecida obra escultórica, Armajani é também um ensaísta,

sendo autor do texto “Manifesto public sculpture in the context of american democracy”

(Armajani, 1995), que acompanhou a exposição “Espaços de Leitura” que apresentou, em 1995,

no Museu d’Art Contemporani de Barcelona (MACBA). O interesse da obra de Armajani decorre

da mesma resultar de um inequívoco engagement a um ideário sócio-utópico-artístico que

problematiza o estatuto do regime autoral, e que rejeita a autorreferencialidade da obra, circunstância

rara no contexto da produção artística contemporânea. Esteticamente contemporânea, a

obra de Armajani logra resolver um dos dilemas mais amargos da arte moderna e contemporânea,

formulado por Arnold Schoenberg: “se é arte, não é para todos, e se é para todos não é arte”

(Schoenberg, 1950, p. 124). Curiosamente, o ideário veiculado por Armajani não é em absoluto

inédito. Em múltiplos aspetos o mesmo coincide com o do movimento em prol da arte pública

que se formou na Bélgica, nos finais do século XIX, e que deu origem à organização de quatro

congressos internacionais de arte pública, dois deles com participação portuguesa documentada,

aspeto por onde se inicia o presente estudo.
Para uma metodologia visual em ação na investigação-criação: o exemplo de SORODAS
Authors: Brandon Carole , Veyrat Marc
Published: June 2020

Este texto apresenta uma metodologia em funcionamento no Departamento de Comunicação

Hipermédia da Universidade Savoie Mont Blanc, França, que se baseia, há vários anos,

numa estreita colaboração entre as Ciências da Informação/Comunicação e as Ciências da Arte,

a fim de permitir a produção de dispositivos inovadores na investigação-criação de artes digitais,

nomeadamente dispositivos construídos em hipermédia. Um testemunho desta estratégia

é a obra SORODAS de Carole Brandon, planeada para o Atelier-Laboratoire IDÉFI-CréaTIC[S]

Langue[S] & Patrimoine[S], que seria deslocalizado para as ilhas de Mayotte no Oceano Índico,

em 2018. Mesmo que a viagem da equipa deste projeto tenha sido finalmente cancelada dois dias

antes da partida, devido a eventos e manifestações ocorridos na ilha, este dispositivo hipermédia

e artístico foi acompanhado por um longo trabalho preliminar interdisciplinar, de pesquisa em

antropologia visual e metodologia de projeto, conduzida em conjunto pela equipa de Ghislaine

Chabert e Carole Brandon. Contando com a colaboração dos alunos do Mestrado Digital Creation,

este território de Mayotte, difícil de circunscrever devido ao seu afastamento geográfico e

ao seu passado tumultuoso, não poderia decentemente ser abordado sem diversas precauções

entretanto tomadas. O presente texto inclui uma amostra dos resultados obtidos, apresentados

parcialmente num estilo de escrita inspirado na linguagem das redes sociais e experimentado no

projeto. Por exemplo, os autores escrevem “®ver” em vez de “rever”, para sublinhar a dualidade

do processo de “(re)visão” no tempo. Ou por vezes substituem os parêntesis simples ( ) por

(-! !-), ou seja, usam a notação emojis, formada por ideogramas e smylies, muito frequente no

ciberespaço e nas redes sociais digitais.
Huebener, P., O’Brien, S., Porter, T., Stockdale, L. & Zhou, Y. (Eds.) (2017). Time, globalization and human experience. Londres: Routledge.
Authors: Araújo Emília
Published: June 2020

Esta recensão versa sobre o livro Time, globalization and human experience, publicado
em 2017. Na obra participam autores, cujas trajetórias académicas estão ligadas aos
Estudos Culturais, Estudos Sociais da Ciência e da Tecnologia e Estudos dos Média. É
um livro de grande atualidade e que contribui para o exercício da política na contemporaneidade.
A sua leitura oferece uma análise da globalização, suas implicações e efeitos, a
partir do conceito de tempo. Os diversos capítulos revisitam autores como David Harvey
e escavam alguns detalhes do tempo no espaço mundial.
Stalder, F. (2018). The digital condition. Cambridge: Polity Press.
Authors: Barranha Helena
Published: June 2020

Ao longo das últimas décadas, a palavra “digital” tornou-se recorrente nos mais

diversos discursos e meios de comunicação. Usada tanto como substantivo como para

qualificar diferentes ações, produtos e experiências, passou a fazer parte do léxico quotidiano

surgindo, ao mesmo tempo, como palavra-chave em inúmeros projetos e artigos

científicos. Em conjunto, estas distintas abordagens contribuíram para um consenso generalizado

em torno da ideia de que as tecnologias digitais condicionam todas as esferas

da vida contemporânea. Mas o que caracteriza, exatamente, a “condição digital” em que

vivemos? Se a questão era já pertinente em 2016, quando a primeira edição do livro de

Felix Stalder foi lançada, a sua relevância é hoje ainda mais evidente...