bluuebunny/crossref_metadata_2025 huggingface dataset:
The Arctic Monitoring and Assessment Programme
Authors: Reiersen Lars-Otto , Guardans Ramon , Sydnes Leiv K.
Published: May 2020

After World War II, the Cold War generated significant barriers between the East and the West, and this affected all sorts of cooperation, including research and scientific collaboration. However, as the political situation in the Soviet Union started to change in the 1980s under the leadership of Mikael Gorbachev, the environment for international collaboration in many areas gradually improved.
On the fractional deformation of a linearly elastic bar
Authors: Lazopoulos Konstantinos A. , Lazopoulos Anastasios K.
Published: May 2020

Fractional derivatives have non-local character, although they are not mathematical derivatives, according to differential topology. New fractional derivatives satisfying the requirements of differential topology are proposed, that have non-local character. A new space, the Λ-space corresponding to the initial space is proposed, where the derivatives are local. Transferring the results to the initial space through Riemann-Liouville fractional derivatives, the non-local character of the analysis is shown up. Since fractional derivatives have been established, having the mathematical properties of the derivatives, the linearly elastic fractional deformation of an elastic bar is presented. The fractional axial stress along the distributed body force is discussed. Fractional analysis with horizon is also introduced and the deformation of an elastic bar is also presented.
Classification of poplar trees with object-based ensemble learning algorithms using Sentinel-2A imagery
Authors: Tonbul H. , Colkesen I. , Kavzoglu T.
Published: May 2020

The poplar species in the forest ecosystems are one of the most valuable and beneficial species for the society and environment. Conventional methods require high cost, time and labor need, and the results obtained vary and are insu˚cient in terms of achieved accuracy level. Determination of poplar cultivated fields and mapping of their spatial sites play a vital role for decision-makers and planners to enhance the economic and ecological value of poplar trees. The study aims to map Poplar (P. deltoides) cultivated areas in Akyazi district of Sakarya, Turkey province using various combinations of the Sentinel-2A image bands. For this purpose, object-based classification based on multi-resolution segmentation algorithm was utilized to produce image objects and ensemble learning algorithms, namely, Adaboost (AdaB), Random Forest (RF), Rotation Forest (RotFor) and Canonical correlation forest (CCF) were applied to produce thematic maps. In order to analyze the effects of the spectral bands of the Sentinel-2A image on the object-based classification performance, three datasets consisting of different spectral band combinations (i.e. four 10 m bands, six 20 m bands and ten 10m pan-sharpened bands) were used. The results showed that the RotFor and CCF classifiers produced superior classification performances compared to the AdaB and RF classifiers for the band combinations regarded in this study. Moreover, it was found that determination of poplar tree class level accuracy reached to ~94% in terms of F-score. It was also observed that the inclusion of the six spectral bands at 20 m resolution resulted in a noteworthy increase in classification accuracy (up to 6%) compared to single 10m band combination.
NEAT1 aggravates sepsis-induced acute kidney injury by sponging
miR-22-3p
Authors: Feng Yawei , Liu Jun , Wu Ranliang , Yang Peng , Ye Zhiqiang , Song Furong
Published: May 2020

Background and aim

Acute kidney injury (AKI) is a common complication of sepsis. Long noncoding RNA
nuclear-enriched abundant transcript 1 (NEAT1) plays a vital role in various
diseases, including AKI. This study aimed to investigate the function and
mechanism of NEAT1 in sepsis-induced AKI.

Materials and methods

A septic AKI model was established by treating HK-2 cells with lipopolysaccharide
(LPS). The levels of NEAT1 and miR-22-3p were measured by quantitative real-time
PCR. Cell apoptosis was assessed by flow cytometry. The levels of
apoptosis-related protein and autophagy-related factors were examined by the
western blot assay. An enzyme-linked immunosorbent assay was used to calculate the
contents of inflammatory factors. The interaction between NEAT1 and miR-22-3p was
validated by dual-luciferase reporter assay, RNA immunoprecipitation assay, and
RNA pull-down assay. The levels of nuclear factor (NF)-κB pathway-related
proteins were evaluated by the western blot assay.

Results

NEAT1 was upregulated, while miR-22-3p was downregulated in patients with sepsis
and in LPS-stimulated HK-2 cells. LPS treatment triggered cell apoptosis,
autophagy, and inflammatory response in HK-2 cells. NEAT1 knockdown attenuated
LPS-induced cell injury. NEAT1 modulated LPS-triggered cell injury by targeting
miR-22-3p. Furthermore, NEAT1 regulated the NF-κB pathway by modulating
miR-22-3p.

Conclusion

Depletion of NEAT1 alleviated sepsis-induced AKI via regulating the
miR-22-3p/NF-κB pathway.
Agamben’s two missing factors; Understanding state of emergency through colonialism and racial doctrine
Authors: Amarasinghe Punsara , Rajhans Sanjay K.
Published: May 2020

The idea of state of exception and sovereignty presented by Italian political philosopher Giorgio Agamben in the aftermath of post September 11 context generated a new discourse in the realms of public law and political philosophy on how law and its protection becomes invalid under state of exception as Agamben showed how suspension of constitutional liberties within so called state of exception legally erases any status of an individual regardless international legal or constitutional norms. However, this article seeks to examine how Agamben had excluded the nature of state of emergency doctrine in colonial societies under European colonialism, where emergency regulations were frequently adopted by colonial masters in subordinating the colonized and at the same time this article will focus on the racial element appeared behind enacting state of emergency in both colonial era and modern states. The objective of this article lies in underpinning much important, yet neglected two factors in whole state of emergency scenario. The results emerging from this article will demonstrate how Eurocentric academic thinking has abandoned some real pertinent issues in constructing the notion on state of emergency.
Bruno Leoni’s Concept of Law and Representation in The Cyber Age: A Cybernetic Model
Authors: De Benedetti Mario
Published: May 2020

The purpose of this article is to contextualize Bruno Leoni’s political theory within the Digital Information Society, a new dimension of public participation in the political arena and a sign of the democratic transition through new forms of involvement by public opinion. In particular, the evolution of the Information Society will be briefly examined starting from the studies of Fritz Machlup, considered its progenitor, to pass to the examination of the Leonian concept of law and politics in the technological society, with reference to Norbert Wiener and Karl Deutsch’s cybernetic theory. This paper will attempt to describe the evolutive process of political participation in democratic society by reinterpreting the thought of Bruno Leoni concerning Democracy, the State and the homo telematicus in the digital social order.
Dissociable Behavioral and Neural Correlates for Target-Changing and Conforming Behaviors in Interpersonal Aggression
Authors: Takami Kyosuke , Haruno Masahiko
Published: May 2020

Actors in interpersonal aggression such as bullies change their targets frequently, but the underlying behavioral and neural mechanisms are unknown. Here, using the catch-ball task we recently developed to examine human interpersonal aggression, we found target-changing and conforming to other participants’ aggression are major driving forces of increased aggression (i.e., throwing strong balls). We also found that target-changing was correlated with a participant’s extraversion, consistent with a bistrategic view, in which both prosocial and coercive motivations drive interpersonal aggression. In contrast, conforming to others was correlated with social anxiety. In addition, questionnaires about participants’ past experiences of bullying suggested that target-changers and conformers were predominantly bullies and victims in the past. An analysis of resting-state functional magnetic resonance imaging (fMRI) revealed that functional connectivity between the dorsal anterior cingulate cortex (dACC) and insula were correlated with target-changing behavior, while functional connectivity between the amygdala and temporo-parietal junction (TPJ) was correlated with conformity. These results demonstrate that target-changing and conforming behaviors have dissociable behavioral and neural mechanisms and may contribute to real-world interpersonal aggressions differently.
Targeting Morphine-Responsive Neurons: Generation of a Knock-In Mouse Line Expressing Cre Recombinase from the Mu-Opioid Receptor Gene Locus
Authors: Bailly Julie , Del Rossi Natalie , Runtz Léonie , Li Jing-Jing , Park DaWoon , Scherrer Grégory , Tanti Arnaud , Birling Marie-Christine , Darcq Emmanuel , Kieffer Brigitte L.
Published: May 2020

The mu-opioid receptor (MOR) modulates nociceptive pathways and reward processing, and mediates the strong analgesic and addictive properties of both medicinal as well as abused opioid drugs. MOR function has been extensively studied, and tools to manipulate or visualize the receptor protein are available. However, circuit mechanisms underlying MOR-mediated effects are less known, because genetic access to MOR-expressing neurons is lacking. Here we report the generation of a knock-inOprm1-Cre mouse line, which allows targeting and manipulating MOR opioid-responsive neurons. A cDNA encoding a T2A cleavable peptide and Cre recombinase fused to enhanced green fluorescent protein (EGFP/Cre) was inserted downstream of theOprm1gene sequence. The resultingOprm1-Cre line shows intactOprm1gene transcription. MOR and EGFP/Cre proteins are coexpressed in the same neurons, and localized in cytoplasmic and nuclear compartments, respectively. MOR signaling is unaltered, demonstrated by maintained DAMGO-induced G-protein activation, andin vivoMOR function is preserved as indicated by normal morphine-induced analgesia, hyperlocomotion, and sensitization. The Cre recombinase efficiently drives the expression of Cre-dependent reporter genes, shown by local virally mediated expression in the medial habenula and brain-wide fluorescence on breeding with tdTomato reporter mice, the latter showing a distribution patterns typical of MOR expression. Finally, we demonstrate that optogenetic activation of MOR neurons in the ventral tegmental area ofOprm1-Cre mice evokes strong avoidance behavior, as anticipated from the literature. TheOprm1-Cre line is therefore an excellent tool for both mapping and functional studies of MOR-positive neurons, and will be of broad interest for opioid, pain, and addiction research.
Sexual Behaviours for Contracting Sexually Transmitted Infections and HIV at Badung Traditional Market, Bali
Authors: Pradnyawati Luh Gede , Ani Luh Seri , Januraga Pande Putu
Published: May 2020

Studies on sexual behaviours are mainly conducted among high risk populations, only limited publications from female general population. This study aims to explore sexual behaviours among women who work at the biggest traditional market in Bali Province. A mix-methods approach was used to study women who work at the Badung Market in Bali. In October 2016, a survey of 100 women was conducted, then followed by a total of 20 in-depth interviews. Quantitative data were analysed using descriptive statistic, while qualitative data were analysed using thematic approach. Our survey found that 60% of respondents were perceived themselves as a low risk group. As many as 22% of respondents admitted that they had sexual intercourse with more than one partner over the last years with 41% of them used condom on their last sexual intercourse. In-depth interviews revealed that the basis of their sexual intercourse was mutual interests and desire. Only one respondent admitted economic reasons for sexual intercourse. Condoms were rarely used because of low risk perception of the sexual intercourse. Prevention programs targeting low risk groups are required to reduce the burden of disease from STIs including HIV.
The Relationship between Previous Tuberculosis Treatment and HIV Status with Multidrug-Resistant Tuberculosis
Authors: Nugrahaeni Dyan Kunthi , Zaqiya Salma
Published: May 2020

Multidrug-resistant tuberculosis (MDR-TB) is becoming major public health issues in the world. Among the causes are history of previous TB treatment and increased co-infection of TB-HIV (Human Immunodeficiency Virus). This study aimed to identify the relationship between history of previous TB treatment and HIV status with MDR-TB. This is a case control study. The sample case was patients with MDR-TB, while sample control was patient who have drug-sensitive TB. Secondary data was obtained from patient medical records and laboratory results at Rotinsulu Pulmonary Hospital Bandung. Data were analyzed using chi-square. Multiple logistic regression was used to identify the dominant factor that influence the occurrence of MDR-TB. This study showed that the history of previous TB treatment was statistically significant with MDR-TB (p value= 0.001; OR= 18.889; 95% CI= 4.093-87.172) and it is the dominant factor that influence MDR-TB (p value= 0.0001; OR= 56.84; 95% CI= 6.9- 468.87). HIV infection at control group (who contracted drug-sensitive TB) was 26.1% (p value= 0.022). This finding suggested that HIV testing should be performed to each TB and MDR-TB patients and increased collaboration TB-HIV program between the other health care facilities should ensue. Drug sensitivity testing should be conducted at the start of TB treatment for patients with previous TB treatment and TB-HIV co-infection.
Challenges of PMTCT and MCHS Integration in Indonesia, Analysis by Integration Analysis Framework and CFIR
Authors: Wiraharja Regina Satya , Trisnantoro Laksono , Mahendradhata Yodi , Praptoharjo Ignatius
Published: May 2020

Integration was strategy of PMTCT (Prevention of Mother to Child HIV Transmission) and MCHS (Mother and Child Health Services) since 2006. This systematic review explored integration level between PMTCT and MCHS. Literature searched from June 2015 to January 2016 through Google, Google Scholar, University Library Website, Portal Garuda, ProQuest, PubMed and 90 institutions in Jakarta. Keywords were PMTCT, HIV Mother, PPIA HIV Evaluation and HIV PMTCT Evaluation. We yielded 157 literatures from 1995-2015. Research should be done at Public Primary Health Care (PHC), discussed PMTCT implementation, and captured perspectives of staffs or decision makers. Thematic analysis was done using Atun’s Integration Analysis Framework and CFIR. We included 7 studies. No study explored overall dimensions of integration, especially planning function. Challenges were resources, execution, needs of patients, networks and communications, policies, leadership, and access to information. Only 4 studies showed PMTCT results. Coverage of first visit counseling was 9-100% and percentage of pregnant women tested was 3.9 -60%. PMTCT integration was partial. Integration was not a sole solution to results. Planning should be done together with regional and local level, involving stakeholders to disseminate PMTCT information, increasing ownership and leadership. We proposed Atun’s Framework and CFIR for further research.
Indonesia Hospital Cost Analysis: a Micro-Costing Approach
Authors: Dianingati Ragil Setia , Riewpaiboon Arthorn , Youngkong Sitaporn
Published: May 2020

Efforts to develop the financing methods is needed to strengthen the Indonesia’s recently implemented universal health coverage system. Hospital cost data is urgently needed to calculate the unit cost of medical services that is important to evaluate the reimbursement rate setting. The most recent approach to calculate unit cost of medical services in hospital is micro-costing approach. This study aimed to perform a unit cost calculation using micro-costing approach in Indonesia’s district hospital in June-Dec 2016 from the provider perspective. The costing study followed the standard costing method and financial data were obtained through the hospital financial reports. Some financial data were directly measured since this study used bottom-up approach. This study showed that the unit cost was not relevant with the reference price set up by the government. It could be caused by different cost items and cost objects that had been employed in the study since the government tariff’s did not have clear and detailed information about the source of cost calculation. Micro-costing approach was useful as a precise method to calculate unit cost, even though rigorous efforts were needed to complete the data.
Physical Fitness of Adolescent Smoker
Authors: Irawan Fajar Awang , Putra Ariawan Achmad , Chuang Long-Ren
Published: May 2020

Adolescent smoking behavior has a bad influence on health and fitness. The purpose of this study was to determine vital capacity and hemoglobin level in smoker and non-smoker adolescent towards physical fitness. The study was quantitative research with surveys and measurement tests. The sample size was 40 adolescents which in the neighborhood of Gunungpati. We used t-test, MANOVA and post hoc test to determine the differences in smoker and non-smoker adolescent. This study showed smoker adolescents had lower vital capacity compared than non-smoker adolescents. The value of hemoglobin levels in smoker adolescents were higher than non-smoker adolescents so that it affect the low levels of physical fitness. For adolescents, it is expected to maintain physical fitness through physical activity and reduce the number of cigarettes consumed and even try to stop smoking for smoker adolescents..
Effectiveness of Early Exercise Against Uterine Involution in Spontaneous Postpartum Patients
Authors: Nurafifah Dian , Kusbiantoro Dadang
Published: May 2020

It is estimated that 50% of puerperal mortality occur within the first 24 hours. At thistime the involution process occured. Involutionary disorders cause complications whichis the leading cause of maternal mortality. Most of postpartum women do not obtainexercise guidance after giving birth. They are only advised to do simple mobilizationwithout planned guidance. The purpose of this study was to determine the effectivenessof early exercise against uterine involution (fundus and lochea). The research methodused Quasi Experimental (pre-post test non equivalent control group design). It wasconducted from May to August 2017. The samples were 40 respondents spontaneousprimiparous postpartum mother. The study was started by 1) divided the samples intocontrol group and treatment group, 2) measured the fundus and lochea, 3) providedearly exercise on treatment group, 4) re-measured fundus and lochea in both groups, 5)analyzed the effectiveness of early exercise to fundus and lochea expenditure decrease.The data analysis used Mann Whitney with α = 0.05. The results showed p value is 0.000(fundus) and p value are 0.001 (lochea). It means that early exercise is effective againstuterine involution (fundus and lochea). The results can provide positive contribution inpreventing maternal mortality caused by puerperal complications.
The Potential of Stigma and Gender related Local Wisdom to Conduct Region based HIV and AIDS Prevention
Authors: Sistiarani Colti
Published: May 2020

Prevention of HIV and AIDS Transmission requires a program approach to solve the problem. The red zones of HIV and AIDS in Banyumas Regency are Cilongok and Purwokerto Selatan. The data from Banyumas Regency Health Office showed that until September 2015 there were 301 cases of HIV, while in 2016, there were 279 cases of HIV and AIDS cases, hence, there was a cumulative increase of cases every year. This study was conducted in August to October 2017. This study used qualitative approach with phenomenology design which was done to understand the potential of local wisdom regarding prevention of HIV and AIDS in relation with stigma and gender based on region. The data were collected through in-depth interviews on household targets in Cilongok and Purwokerto Selatan districts, represented 7 male informants and 16 female informants. The data were analysed using content analysis with narrative form. This study found that the informant did not know about the stigma, but they knew about the risk factors of HIV transmission. The informant knew about gender equality and the division of roles between husband and wife. Potential local wisdom that could be developed to prevent HIV and AIDS in the community were mutual respect, communication, mutual assistance in the division of roles in the household.
Unified Theory of Acceptance and Usage of Technology (UTAUT) Model to Predict Health Information System Adoption
Authors: Nurhayati Siti , Anandari Dian , Ekowati Wahyu
Published: May 2020

In order to improve the quality and performance of health services, health information systems are one of the most important technologies in health management. This study aims to determine the factors that influence the adoption of nutrition information system by nutrition officers of primary health care by using Unified Theory of Acceptance and Usage of Technology (UTAUT) Model. This research is quantitative research with survey approach, located in 39 primary health care of Banyumas district. Sampling technique using purposive sampling. Respondents are 50 people. The research instrument used questionnaire. Based on regression test results known that factors related to use behaviour is behavioral intention. While the facilitating condition is not related to use behavior. Factors associated with behavioral intention is the performance expectancy, effort expectancy and social influence.
Predisposing, Enabling and Reinforcing Factors of Premarital Sex Behavior in School Adolescents
Authors: Ayu Suci Musvita , Sofiana Liena , Wibowo Marsiana , Gustiana Erni , Setiawan Arie
Published: May 2020

Nowadays, 60% adolescents in Indonesia admitted that had practiced premarital sexbehavior and 50% of people living with HIV and AIDS are adolescent age group. Thenegative consequences of sex behavior which causes an Indonesian adolescent disruptedopportunities continue study at school, enter the work force, starting become a familyand become a member of society as well. Premarital intercourse makes unintendedpregnancy rates still high. Based on data obtained from the Pekanbaru City HIV-AIDSManagement Commission (KPA) in April 2017, it was found that HIV-AIDS caseshave always increased from year to year. The purpose of this study was to determinethe correlation between predisposing, enabling, and reinforcing factors with premaritalsex behavior in adolescents. The design was cross sectional study. This study was conductedAugust 2017 with multistage random cluster sampling and with 481 adolescentrespondents in 18 SMA in Yogyakarta City, which were analyzed using Chi Square test.There were a relationship of knowledge (p = 0.000, RP = 3.893), attitude (p = 0.000, RP= 7.240), self-esteem (p = 0.000, RP = 3.502), source of information (p = 0.003) and peerroles (p = 0.000, RP = 11.660) with premarital sex behavior. Meanwhile, there were norelation of family role (p = 0.436, RP = 0.823) and teacher role (p = 0.053 RP = 1.596)with premarital sex behavior. Knowledge, attitudes, self-esteem, information source andthe role of peers are related to premarital sex behavior. The role of the family and the roleof the teacher are not related to premarital sex in adolescents.
Social Determinants of Health of Child Marriage (Analysis of IFLS 2000, 2007, 2014)
Authors: Wahyudi Tri , Hasanbasri Mubasysyir , Kusnanto Hari , Hakimi Mohammad
Published: May 2020

Early marriage is defined as a marriage of women aged <18 years old. The current world prevalence is declining, but when compared with the growth in population, the total number of married children tends to increase. Today, early marriage reaches 41.000 every day, especially in Sub-Saharan Africa and South Asia. This research aims to identify the social determinants of health that encourage early marriage. This research used a quantitative observational analytic study with cross-sectional design. The number of <18 year-old married women were 1.96% (IFLS5), <18 year-old married men were 0.15% (IFLS5). The average age at first birth was 22.96 years old. The economic status of early marriage was mostly in Quintile 1, and the majority of residences were in rural area. The ratio of married women and men aged <18 years old was 11-14: 1. Employment, education, residence and poverty were associated with early marriage and were statistically significant.
Ecological Study on Factors Related to the Mortality of Rabies in North Sulawesi Province at the Year of 2015 to 2017
Authors: Tiarma Noer Syafiiah , Machmud Putri Bungsu
Published: May 2020

Indonesia, which is part of the region, contributes 25 provinces including areas that have not been free from the endemic of rabies. One of the provinces that ranked top in the cases of rabies was North Sulawesi. Therefore, this study aims to find correlations between factors related to the prevalence of rabies deaths in North Sulawesi Province in 2015 - 2017. This study used a mixed ecological study design by applying the principle of total sampling to 15 districts/citiesin North Sulawesi. The results of the study found that there was a negative and weak strength correlation on the anti rabiesvaccine coverage factor (r = 0.279), moderate strength correlation on the ratio of health care workers (r = 0.345), and the ratio of health care facilities (r = 0.320) to the mortality of rabies. While the sex ratio factor is positive and has moderate strength (r = 0.365) against the mortality of rabies. The new findings of health care facility and health care workers that have a moderate strength correlation need to be included in the prevention of rabies approach because it can help to facilitate washing wounds treatment.
Risk Factors and Early Symptoms Related to Respiratory Disease in Pedicab Drivers in Surabaya
Authors: Lorensia Amelia , Suryadinata Rivan Virlando , Diputra I Nyoman Yoga
Published: May 2020

Various factors which cause respiratory diseases such as smoking, air pollution, and disease history are found in pedicab. The purpose of this study was to understand the risk factors and early symptoms that related to respiratory disease in pedicab drivers. This study used observational cross-sectional design with purposive sampling. Variables that were recorded in this study were lung function risk factors and early symptoms of respiratory disorders. The number of samples was 148 respondents (135 with respiratory disorder and 13 without respiratory disorder). The results of this study found the most common risk factor was air pollution exposure. In 145 respondents (97.97%), the average lung function was 52.56%. The most frequent early symptom was dyspnea with percentage of 7.43% and average lung function value of 26.20%. Air pollution was the most common risk factor and dyspnea was the most common early symptom in pedicab drivers with respiratory disorders in Surabaya.
Factors Affecting Pregnant Women in Preparation of Early Breastfeeding Initiation (IMD) at Grobogan Regencys
Authors: Yuliana Aniestia , Rahfiludin M. Zen , Nugraheni Sri Achadi
Published: May 2020

Exclusive breastfeeding will be realized if mother start implementing Early Breastfeeding Initiation (IMD) program. The purpose of this study is to investigate factors influencing pregnant women in preparation for early breastfeeding initiation (IMD) in Grobogan regency. Study method is quantitative with cross-sectional design. Total population is 716 pregnant women with minimal of 85 sample after calculations. To anticipate drop out, 100 samples will be collected. Independent variable is the factors influencing preparation of IMD in pregnant women and dependent variable is preparation of Early Breastfeeding Initiation (IMD). Data was analyzed using multiple logistic regression. The analysis showed no significant relation between factors such as education, knowledge, attitudes, breastfeeding experience, husband/family support, participation in classes of pregnant women, the role of health workers with preparation for IMD. In contrast, the variable trust had a significance value of 0.001 <0.05. We conclude that IMD preparation of pregnant women is most influenced by trust.
Knowledge, Behavior, and Role of Health Cadres in The Early Detection of New Tuberculosis Case in Wonogiri
Authors: Ratnasari Nita Yunianti , Marni Marni , Husna Putri Halimu
Published: May 2020

Tuberculosis (TB) is an infectious disease that remain a serious health problem. Seventy five percent of TB cases in developing countries are found in people of productive age. Delay in case finding and handling will lead to disability and death and hamper TB control program. The objective of this study was to evaluate how far the role of health cadres in detecting new case of TB in Tirtomoyo, Wonogiri. The study design was a cross-sectional and data was collected from February to April 2019. The population of the study was all health cadres in Tirtomoyo numbering 465 cadres from 9 villages. Sample of the study was the cadres in Tirtomoyo who met inclusion criteria set by the researchers with total number of 202 cadres. The sampling technique was purposive sampling, and the inclusion criteria included: active person, in a healthy state, not currently receiving inpatient care in hospital, and agree to participate in the study. Subjects completed the questionnaire consisting of sociodemographic data, knowledge, behavior, and the role of cadre. The data was analyzed using SPSS version 22. The behavior of the health cadres was found to significantly correlate to the role of cadres in early detection of new TB cases with p value of 0.039 (OR 0.121– 0.946). The health cadres play an essential role, and active screening for TB detection was more effective than passive screening. Early diagnosis would affect the success of the TB treatment program.
Factors Associated with Depression among Prisoners in Women’s Class II-A Prison Jakarta
Authors: Juliane Zhara , Machmud Putri Bungsu
Published: May 2020

Depression is a common mental disorder, characterized by persistent sadness and a loss of interest in activities that you normally enjoy, accompanied by an inability to carry out daily activities, for at least two weeks. Female prisoners represent groups at risk of depression where depression in prisoners is more vulnerable to female prisoners than men. This study aims to determine the factors associated with depression among prisoners in Women’s Class II-A Prison Jakarta. The study design used was cross-sectional with multivariate analysis, multiple logistic regression. The number of research samples is 200 prisoners taken using random sampling techniques. The results showed that the prevalence of depression among prisoners in Women’s Class II-A Prison Jakarta is 56,5%. Based on the results of the multivariate analysis, it can be seen that factors related significantly to depression are age (p-value = 0.012; POR = 2.144; 95% CI = 1.185 - 3.879) and recidivism status (p-value = 0.043; POR = 3.926; 95% CI = 1,047 –14,729) which the most influential factor on the incidence of depression is recidivism status. Government attention needs to be given to the mental health of prisoners by conducting various mental health programs and services such as regular screening and rehabilitation programs.
Utilization of Antenatal Care (ANC) Services by Pregnant Women in Binjai City and Factors Affecting
Authors: Wau Herbert , Razella Nidya
Published: May 2020

Antenatal care services have an influence on fetal growth or during pregnancy, one effort to reduce maternal mortality due to complications is through the use of antenatal care. Based on data from the Health Profile of Kebun Lada Public Health Center, it is known that the scope of ANC services (K1 and K4) in 2017 is K1 96% AND K4 84%. In 2018 that is K1 82.7% and K4 81%. Where there is a difference in the percentage of coverage of K1 and K4 visits. The research was an analytical survey using Cross Sectional with a sample of 76 people. This research uses chi-square data analysis method with accidental sampling technique to find out the significant influence between, Knowledge, Attitude, ANC Service Facilities, Husband / Family Support and Health Staff Support. This research shows there is influence of Knowledge (p = 0,000), Attitude (p = 0,000), Service Facilities (p = 0,000), Husband / family Support (p = 0,000), Officer Support with (p = 0,001) with Utilization of Antenatal Care Services where p-value <0.05. This study, showed that all factors affect the Antenatal Care service. Health workers, especially midwives, are expected to maintain health education and promotion and motivation on a regular basis about the importance of regular antenatal care.
Identification of Causes and The Existence of Mercury and Chromium in Sediment and Sea Water in Kendari Bay
Authors: Damayanty Sri , Kamal Muhammad , Pawennari Muhammad Arief
Published: May 2020

Kendari Bay is currently experiencing considerable physical pressure and pollution due to heavy metals. This study aims to determine the content of heavy metals mercury and chromium in sediment and seawater in Kendari Bay. This study uses an observational design with a descriptive approach. The study was conducted in April 2019 in five Port areas with three sampling points in each region. Samples taken are sediment and seawater. Samples taken were analyzed by the Atomic Absorption Spectrophotometry (AAS) method. The results show that all sampling points at five Ports have been contaminated with mercury and chromium in sediment and seawater. The levels of mercury and chromium have exceeded the quality standards stipulated by Minister of Environment Decree No. 51 of 2004. The highest levels of mercury and chromium in seawater and sediment are highest in the Dermaga Tempat Pendaratan Ikan (TPI). This is due to the dense traffic activity of fishing vessels, residential waste, Hospital waste, hospitality waste, tourist waste, paints on ships, oil spills, rust from shipwrecks, and heavy equipment activities from the construction of the Bahteramas Bridge or the Kendari Bay Bridge. Technology needs to control heavy metal contamination as well as policies and law enforcement regarding activities at sea that have the potential to pollute waters.
The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF
Authors: Cabry Rosalie , Merviel Philippe , Madkour Aicha , Lefranc Elodie , Scheffler Florence , Desailloud Rachel , Bach Véronique , Benkhalifa Moncef
Published: May 2020

The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (1) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects and poor IVF outcomes, and (2) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates, and elevated risk of miscarriage associated with exposure to high doses of pesticides.
Surgical Treatment of Coronary Pseudoaneurysm: A Case Report and Literature Review
Authors: Xiang Haiyan , Gao Rifeng , Yan Juesheng , Li Juxiang , Li Jin , Lu Fei , Tang Yanhua
Published: May 2020

A coronary pseudoaneurysm is a rare complication of chest trauma. In this report, we describe the case of a 65-year-old man with a mediastinal lesion. On admission, he complained of chest tightness and dry cough, and a pseudoaneurysm was confirmed in the left anterior descending branch of the coronary artery on chest computerized tomography, angiography, and coronary angiography. The patient had experienced chest trauma 5 years previously. With the help of extracorporeal bypass surgery, the pseudoaneurysm was resected under direct observation. The patient recovered well after surgery. Traumatic coronary artery pseudoaneurysms usually are asymptomatic and often misdiagnosed. Preoperative coronary angiography is a crucial diagnostic used for deciding appropriate surgical management.
ОБҐРУНТУВАННЯ СТРАТЕГІЧНИХ НАПРЯМІВ УДОСКОНАЛЕННЯ ОРГАНІЗАЦІЇ ЗБУТОВОЇ ДІЯЛЬНОСТІ ВУГІЛЬНИХ ПІДПРИЄМСТВ УКРАЇНИ
Authors: ЗАЛОЗНОВА Юлія , ТРУШКІНА Наталія
Published: May 2020

Досліджено особливості функціонування підприємств вугільної промисловості з точки зору організації процесів збутової діяльності, що дозволило уточнити суть і зміст термінів «збутова діяльність вугільного підприємства», «маркетинг взаємовідносин», «клієнтоорієнтованість», «обслуговування споживачів вугільної продукції», «збутова мережа». На основі аналітичної оцінки основних показників збутової діяльності визначено тенденції її розвитку в ряді вугільних країн світу. Виявлено чинники, які впливають на організацію збутової діяльності вугільних підприємств в Україні, які умовно систематизовано у дві групи: екзогенні (політичні, інституційні, фінансові, ринкові, економічні, інформаційні, екологічні) та ендогенні (маркетингові, технологічні, фінансово-економічні, транспортні, інформаційні).Удосконалено клієнтоорієнтований підхід до обслуговування споживачів вугільної продукції на основі їх диференціації (виокремлення трьох категорій споживачів), який базується на врахуванні обсягів щорічного попиту різних груп споживачів та їх специфічних особливостях. Сформовано науково-методичні засади поєднання в межах реалізації концепції маркетингу взаємовідносин системного, процесного і функціонального підходів з метою вдосконалення обслуговування споживачів вугільної продукції.Обґрунтовано доцільність застосування мережевого підходу до організаціїзбутової діяльності вугледобувних підприємств, суть якого полягає в розробленні трьох моделей збутових мереж як дієвих форм партнерства учасників ринку вугілля. Удосконалено механізм реалізації державно-приватного партнерства при управлінні збутовою діяльністю вугледобувних підприємств на основі організаційно-правової форми синдикату.Запропоновано методичний підхід до вибору оптимального каналу збуту вугільної продукції, який дозволяє з використанням методу аналізу ієрархій визначити найвагоміші критерії та систематизувати їх у групи (економічні, організаційні, ринкові та інформаційні), розрахувати обсяг партії поставки вугілля великооптовим споживачам з урахуванням багатьох чинників.Сформовано систему контрактних взаємовідносин вугледобувного підприємства та споживачів вугільної продукції з метою організації безперервного процесу укладання та виконання умов контрактів на поставку вугілля.
Lipid vesicles: applications, principal components and methods used in their formulations: A review
Authors: Camilo Cicera Janaine Janaine , Leite Débora Odilia Duarte , Silva Angelo Roncalli Alves , Menezes Irwin Rose Alencar , Coutinho Henrique Douglas Melo , Costa José Galberto M
Published: May 2020

Liposomes and niosomes are currently the most studied lipid vesicles in the nanomedicine field. The system formed by a phospholipid bilayer in aqueous medium allows these vesicles to carry both hydrophilic and lipophilic compounds, providing an increase in solubility of drugs lready used in conventional therapy. The focus on the development of these vesicles should be directed to determining the ideal composition, with low toxicity, biocompatibility and which remains stable for long periods. These characteristics are related to the components used for formulation and the substances that will be encapsulated. Another important point relates to the methods used during formulation, which are important in determining the type of vesicle formed, whether these be large or small, unilamellar or multilamellar. Because of the deliberate actions applied in the development of these vesicles, this review sought to gather updated information regarding the different methods used, including their main components while considering the behavior of each of them when used in different formulations. Also, data showing the importance of formulations in the medical field evidencing studies performed with liposome and niosome vesicles as promising in this area, and others, were included. The approach allows a better understanding of the participation of components in formulations such as cholesterol and non-ionic surfactants, as well as the basis for choosing the ideal components and methods for future research in the development of these vesicles.
ACTIVIDAD BIOCONTROLADORA IN VITRO DE MACROHONGOS CONTRA DIFERENTES HONGOS FITOPATÓGENOS
Authors: Patiño Moscoso Manuel Alfonso , Nieto Ramírez Ivonne Jeannette , Chegwin Angarita Carolina , Torres Rojas Esperanza
Published: May 2020

Las enfermedades causadas por hongos en las plantas son una gran preocupación en la producción agrícola. Los macromicetos son una fuente potencial de compuestos antifúngicos que podrían usarse para controlar estas enfermedades. El objetivo de este estudio fue evaluar la actividad biocontroladora in vitro de cuatro macromicetos de los géneros Xylaria, Agrocybe, Psilocybe y Stereum sobre diferentes hongos fitopatógenos. Para ello, se determinó la curva de crecimiento de los macrohongos en dos medios: papa dextrosa (PDA) y salvado de trigo (ST) y se caracterizaron las interacciones y la inhibición in vitro de hongos fitopatógenos. Se realizó la extracción y caracterización de metabolitos secundarios de la biomasa, el medio extracelular y del homogeneizado del micelio y caldo en los hongos con mayor porcentaje de inhibición. Finalmente, se evaluó la actividad antifúngica in vitro de estos extractos. Las curvas de crecimiento cambiaron con la fuente de carbono, tres de cuatro macrohongos mostraron una mayor acumulación de biomasa en PDA que en ST. Las interacciones de Xylaria se clasificaron principalmente como reemplazo, obteniendo el mayor nivel de antagonismo en PDADos de los tres extractos evaluados mostraron actividad antifúngica contra los tres patógenos aislados en concentraciones de 18 μg/ml para extractos metanólicos de biomasa y 2,5 % para el filtrado de homogeneizado con inhibiciones de 10 % a 80 %.  La caracterización de los metabolitos de Xylaria mostró como posibles compuestos responsables de la actividad a los ácidos grasos. Este trabajo mostró el potencial de estos hongos para el control de enfermedades fúngicas.
Systematic considerations on two species of nectarivorous bats (Anoura caudifer and A. geoffroyi) based on barcoding sequences
Authors: Vargas Arboleda Andrés Felipe , Cuadrado-Rios Sebastían , Mantilla-Meluk Hugo
Published: May 2020

As a product of recent revisions of the nectivore bat genus Anoura (Glossophaginae: Anourina), new species have been described, and several taxa have been elevated to the specific level in the so-called Anoura caudifer and A. geoffroyi species complexes in the last four decades. The genus has a wide distribution across regions of high ecological complexity, including geographic features, such as the Andes and the Isthmus of Panamá, previously identified as natural barriers that restrict gene flow in other phyllostomid bat genera. Up to date, no analyses have been conducted to investigate the contribution of biogeographic factors on the genetic divergence of the genus. In this work, we analyze barcoding DNA sequences (cytochrome oxidase subunit I, COI) to test for geographic structure among Central and South American populations of the A. caudifer and A. geoffroyi complexes. Our analyses show geographic structure for populations previously identified as the A. geoffroyi lasiopyga, suggesting an independent evolutionary fate for Central American representatives of the genus. We also highlight the presence of unrecognized diversity within the A. caudifer complex from the Pacific coast of northern Ecuador.
Crecimiento, reproducción y hábitos alimentarios de Stellifer melanocheir (Sciaenidae) en el Golfo de Tortugas, Pacífico colombiano
Authors: Muriel Hoyos Felipe , Carmona Guerra Andrés Felipe
Published: May 2020

Stellifer melanocheir (Eigenmann, 1918) es una especie de pez abundante en la fauna acompañante de la pesca artesanal de camarón de aguas someras. Con el objetivo de estudiar el crecimiento la reproducción y hábitos alimentarios de la especie, se recolectaron 751 individuos (540 hembras, 187 machos y 24 indeterminados) entre septiembre de 2011 y abril de 2012 de la pesca artesanal de camarón de aguas someras del Golfo de Tortugas, Colombia. Los parámetros de crecimiento representados por la ecuación de Von Bertalanffy Lt = 17,8(1-e[−0,62(t+0,34)]) mostraron que la especie presentó un crecimiento alométricamente positivo, más rápido que algunas especies congéneres. Las hembras alcanzan la talla media de madurez (L50) a los 11,7 cm y los machos a 10,9 cm. Se reproduce continuamente con un pico entre septiembre y noviembre, y otro menor en marzo, probablemente aprovechando periodos con aumento de precipitación. La dieta de la especie es similar durante su etapa juvenil y adulta, con un espectro trófico estrecho, carcinófago, con hábitos bentopelágicos. Su principal presa son los copépodos con capturas ocasionales de camarones, las cuales aumentan en los individuos de mayor tamaño.
Identificación de polimorfismos en el gen RXAM1 de yuca y su asociación con la resistencia a la bacteriosis vascular
Authors: Barrera Andrea del Pilar , Soto-Sedano Johana , López Carrascal Camilo Ernesto
Published: May 2020

La yuca (Manihot esculenta Crantz) es un cultivo importante en regiones del trópico que proporciona alimento para cerca de 1000 millones de personas en todo el mundo. La enfermedad bacteriana más importante es la bacteriosis vascular causada por Xanthomonas axonopodis pv. manihotis (Xam). Recientemente se logró identificar un gen de resistencia denominado RXAM1, el cual codifica para una proteína que posee un dominio LRR (Leucine-Rich Repeat) extracelular y un dominio STK (Serine Threonine Kinase) citoplasmático. RXAM1 colocaliza con un QTL que explica el 13 % de la resistencia a la cepa CIO136 de Xam. En este trabajo se evaluó la respuesta a la infección con la cepa XamCIO136 en diez diferentes variedades de yuca lo cual permitió identificar que las variedades TMS60444, SG10735, MCOL1522, MCOL1505 y MCOL2215 fueron susceptibles, mientras que CM6438-14, CM523-7 y MBRA902 se comportaron como resistentes. Así mismo se identificaron polimorfismos tipo SNPs (Single Nucleotide Polymorphism) en el gen RXAM1 en el mismo grupo de variedades. Las variedades SG10735, CM6438-14, TMS6044 y MBRA685 presentaron el mayor nivel de polimorfismos, mientras que las variedades CM523-7, CM2177-2 y MCOL1522 fueron menos polimórficas para este gen. Los análisis estadísticos no permitieron identificar una asociación significativa entre el fenotipo y los polimorfismos identificados. Este estudio representa un primer esfuerzo con miras a asociar variantes alélicas con el fenotipo de respuesta a la bacteriosis vascular.