bluuebunny/crossref_metadata_2025 huggingface dataset:
Dampak Devaluasi Yuan Pada 11 Agustus 2015 Terhadap Abnormal Return Dan Abnormal Trading Volume Activity Saham Yang Tercatat Di Jakarta Islamic Index JII)
Authors: Saputri Windiya , Herlambang Leo
Published: October 2020

Government-related announcement is one of the determinants that potentially affect capital market. This research aims to see the reaction of stock market to Yuan Devaluation on August, 11 2015. The market reaction in this study is indicated by the presence of abnormal retun and abnormal trading volume activty. The approach taken in this research is the quantitative approach with event study method by using one sample t-test and paired sample t-test analysist. The variables in this research are Yuan Devaluation, AAR, and AATVA. The issuers observed in this research are stock listed on JII during the period of study. Results showed that stock listed on JII reacted to Yuan Devaluation, that is showed by significant results both in the AAR and AATVA, which means Yuan Devaluation bears valuable information for investor.
Faktor – Faktor Yang Mempengaruhi Pertumbuhan Aset Bank Syariah Di Indonesia Tahun 2006-2015
Authors: Aisy Diamantin Rohadatul , Mawardi Imron
Published: October 2020

This research aimed to determine the external and internal factors affect to the assets growth of Islamic banking in Indonesia, in time year 2006 until year 2015. The approach is a quantitative approach using PLS (Partial Least Square) analytical techniques with three latent variables, that is external factors as an exogenous variable wich which used to reflect external factors in this research are inflation, GDP Growth, BI rate, and money supply (M2); internal factors as an endogenous variable which are reflected by profit sharing rate, promotion, education and training cost, NPF ratio, ROA ratio, FDR ratio, Third-Party Funds, quantity of office bank, and office channeling; and assets growth of Islamic banking as an endogenous variable. The result of this research showed that external factors has a significant effect to internal factors. However, both external factors and internal factors have no significant effect to the growth of Islamic banking asset.
Komparasi Efisiensi Penghimpunan Dana Pihak Ketiga Bank Umum Syariah Dan Bank Umum Konvensional Di Indonesia Dengan Metode Data Envelopment Analysis
Authors: Yuliati Yuliati , Suprayogi Noven
Published: October 2020

This study aims to determine and comparing the level of third-party funds accumulation efficiency of Islamic Banks and Conventional Banks in Indonesia. This study uses a quantitative non-parametric approach with Data Envelopment Analysis (DEA) CRS and VRS assumption, and statistical tool namely Mann Whitney U-Test. The samples are 10 Islamic Banks and 13 Conventional Banks those comply with the specified sample criteria. During 2010 to 2014, Islamic Banks has efficiency level of third-party funds accumulation relatively higher than Conventional Banks based on CRS and VRS assumption. Source of inefficiency in Islamic Banks is the scale of third-party funds accumulation. While the hypothesis test showed there was no significant difference in the level of third-party funds accumulation efficiency between Islamic Banks and Conventional Banks in Indonesia with the assumption of CRS, VRS, and Scale efficiency.
Penerapan Teknik Analytical Hierarchi Process (AHP) Dalam Pengambilan Keputusan Pembiayaan Produktif (Studi Kasus Pada Bank JATIM Syariah Cabang Darmo)
Authors: Nuzula Firdausi , Septiarini Dina Fitrisia
Published: October 2020

The purpose of this study was to determine the main criteria of decision-making for productive financing based on the level of interest by using AHP technique. Results of this study is the capital criteria become a major criterion in the decision-making productive financing. Most important sub-criteria of Character is payment commitments. Most important sub-criteria of Capacity is obtained from customer turnover per month. Most important subcriteria of Capital is trackrecord of prospective customer payments. Most important subcriteria of Collateral is the ownership of the collateral and the authenticity of the documents. Most important sub-criteria of Condition of Economy is the business both in the side of the law and the government. The results of all the weighting of criteria and sub-criteria through the process of harmonic average from seventh informant’s answers.
Penerapan Tata Kelola Syariah Lembaga Keuangan Islam (Studi Kasus Pada PT. BPRS Jabal Nur Surabaya)
Authors: ‘Aabid Fachruddin , Suprayogi Noven
Published: October 2020

This research aims to analyze the implementation process of good sharia governance (GSG) in order to ensure sharia compliance. Sharia governance is a qualitative disclosure that includes arrangements, systems, and control to ensure sharia compliance. The method using descriptive qualitative approach with case study strategy at PT. Bank Pembiayaan Rakyat Syariah (BPRS) Jabal Nur Surabaya. Data collected by in depth interview and documentation. Validation techniques using source and technic triangulation. Analysis techniques using Miles and Huberman’s.Result of this research is based on seven patterns from the sharia governance process which represents the instrumental function of the sharia supervisory board as part of the internal governance structure of corporate governance in Islamic Financial Institutions. Based on the analysis that has been conducted by researchers, PT. Bank Pembiayaan Rakyat Syariah Jabal Nur has been quite obedient in fulfillment guarantee of sharia compliance based on the implementation process of good sharia governance.
Pengakuan, Pengukuran, Penyajian, Dan Pengungkapan Aset Kelolaan Pada Lembaga Amil Zakat
Authors: Ghufraanaka Ghufraanaka , Septiarini Dina Fitrisia
Published: October 2020

The purpose of this research is to assess the implementation of accounting aspects such as recognition, measurement, presentation and revelation of zakat transactions within LAZISMU in regards to PSAK 109 concerning zakat accounting. This research employs a qualitative descriptive approach with case study methodology. The technique of analysis used within this research is the domain analysis technique. The research determines two domains in relation to zakat accounting, which are acquisition, management and distribution of zakat, infaq and shadaqah. Results suggest that in the aspect of recognition and measurement, LAZISMU demonstrated compliance to the PSAK 109 during the acquisition of zakat, infaq and shadaqah, however LAZISMU failed to show compliance in regard to the aspects of revelation and presentation during the acquisition process. In conclusion, LAZISMU are not compliant to the general guide of zakat accounting, mostly due to lack of able personnel in LAZISMU.
Pengelolaan Keuangan Keluarga Secara Islam Pada Keluarga Muslim Etnis Padang Dan Makassar Di Surabaya
Authors: Endrianti Rosalia Debby , Laila Nisful
Published: October 2020

The goal of this research is understanding how does management financial implementation work into Muslim Family, especially at Padang and Makassar ethnics in Surabaya.This research used descriptive qualitative approach. Data collection was resulted by interview, observation, and documentation. Domain and taxonomy technique was used to perform data analytic. This technique to find the general description of financial management family work into Muslim then elaborated more detail to know the internal structure of Islamic view of wealth, the provision, determine the priority scale, and make budget household.The results based on interviews with two informants from the Padang and Makassar is both informants in research has implemented most components financial management to reach sakinah finance in the life daily. The financial management component are Islamic view of wealth, the provision, determine the priority scale, and make budget household.
Analisis Kriteria Penetapan Nilai Bagi Hasil Pendanaan Dengan Menggunakan Teknik ANP (Studi Kasus Pada Bank JATIM Syariah)
Authors: Nanda Devita Lolla Rizky , Septiarini Dina Fitrisia
Published: October 2020

The purpose of this study was to find out what is the main criteria in determining revenue sharing value of funding based on interdependence level of internal and external factors by using ANP techniques at Bank Jatim Syariah. The research method used is descriptive qualitative approach with study case method. Data collected by interviews, questionnaires, documentation and other literature. Analysis technique used is the technique of Analytic Network Process (ANP) with weighting questionnaires given to the informant. Weighting is done through comparison between the criteria, sub-criteria and sub-criteria traffic. Results from this study are the criteria of internal factors with sub criteria bank revenue of 0.17416 become a major criterion in the decision-making on determination of revenue sharing value of Funding in Bank Jatim Syariah. Results of the weighting of criteria and sub - criteria through the geometricmean of three informants of Bank Jatim Syariah.
Dampak Faktor Pemicu Terjadinya Displaced Commercial Risk Terhadap Keputusan Nasabah Untuk Tetap Menjadi Nasabah Bank Syariah Di Surabaya
Authors: Rohmatur A. Yonindya , Septiarini Dina Fitrisia
Published: October 2020

The purpose of this research is to know if the three factor triggers of Displaced Commercial Risk (DCR) have affect partially to the decision of costumer to remain as the costumer of sharia bank. The method used is quantitative methods through questionnaire using likert scale by multiple linear regression analysis with reliability test and validity, classic assumption test, and hypothesis test.. The sample used is 100 sharia bank’s costumer who comply the criteria sample assigned. simultaneously rate of return, bank’s operational, and profit sharing expectation significantly affect to the decision of costumer, and partially the rate of returnand bank’s operational significantly affect to the decision of costume r, but partially the expectation of profit sharing not significantly affects to the decision of costumer.
Pengaruh Kinerja Manajer Investasi Terhadap Return Reksadana Saham Syariah di Indonesia (Periode 2011-2015)
Authors: Rafika Siti Zulva , Laila Nisful
Published: October 2020

This research aims to find out the influence of stock selection and market timing toward the return of Islamic mutual funds of stock in Indonesia. This study used seven samples of Islamic mutual funds of stock in Indonesia were obtained using purposive sampling. The stock selection and market timing were counted using Treynor Mazuy Model. The approach used in this study is quantitative approach using double regressions. In analyzing the data, the technique used is panel data regression analysis by using Eviews 8 software. The result of this study shows that in the partially test, the stock selection is proven to have significant influence toward the return of Islamic Mutual Funds of Stock in Indonesia, and the market timing also has significant influence toward the return of Islamic Mutual Funds of Stock. The simultaneously test shows that stock selection and market timing significantly influence the return of Islamic Mutual Funds of Stock.
Etika Bisnis Islam Dalam Pengelolaan Bisnis di Pesantren Mukmin Mandiri
Authors: Karishma W Yogiswara , Widiastuti Tika
Published: October 2020

This research is aimed to determine the Islamic Business Ethics in business management at Pesantren Mukmin Mandiri Sidoarjo. Pesantren Mukmin Mandiri is one of pesantren based on agrobusiness and agro-industry which graduates entrepreneurs every year. This research used the qualitative research method and case study as the strategy. Data collection was done by interviewing and observing the research object directly. The qualitative explanatory was used as the technique of analysis by explaining the results of the interviews and of the direct observations.The results of The analysis showed that the business ethics of Islam are in some way and going well in business management in schools independent believer, it can be seen from the implementation of restrictions on the business that is concerned with the students.
The Colors of the Sunrise Academic Edition
Authors: Skarvelakis Anthony
Published: October 2020

An amazing exploration of the mind is now possible for everyone. With the Colors of The Sunrise, the first volume of the series The Psychotherapy of Whole: Aesthetics, Philosophy, Humanism, and Cognitive Science the reader has the opportunity to engage with a book that utilizes the methods and structure of self-help, popular science, and expressive therapies books.

Science, psychotherapy, philosophy, music, art and digital reality for the first time come together in a book phenomenon and a series designed during 16 years to provide the first A.I Psychotherapy model internationally, focused on a profound study that has been evaluated by leading names from many of the areas analyzed around the world.

The book has been based on the background of advanced academic research, lending from the recent and updated investigations in an extraordinary number of areas. These include but are not limited to the disciplines of social sciences, psychiatry, philosophy, expressive art therapies, exact sciences, history, politics, artificial intelligence, and humanities that are presented from a global perspective.

Linguistics, neuroscience, anthropology, robotics, physics, and mathematics reconsidered as positive parts of the universal structures. It is explained the manner of uniting the cognition staying in perfect harmony with the today’s knowledge acquired by cognitive science, and the knowledge that traditionally contributes to the flourishing of the human mind through the philosophical approaches.

This manner discovered through the cutting-edge clinical and scientific study of the author. As a Licensed Social Worker and Cognitive Scientist, Anthony N. Skarvelakis devoted many years of professional investigation to reach a cognitive metaprogram as a model that expands human thought, giving the solution searched for years regarding the design of the first complete model of A.I Psychotherapy.
Ensino remoto emergencial e o estágio supervisionado nos cursos de licenciatura no cenário da Pandemia COVID 19
Authors: Souza Ester Maria de Figueiredo , Ferreira Lúcia Gracia
Published: October 2020

Este artigo aborda o estágio supervisionado nas licenciaturas no contexto da COVID-19. A esse componente dos projetos pedagógicos dos cursos são atribuídas carga horária obrigatória e concepção de profissionalização. As funções sociais do professor em formação inicial moldam seu exercício profissional futuro, sendo essas realizadas no conjunto de práticas de ensino, de pesquisa e de extensão. O estágio curricular obrigatório, na ênfase do ensino, configura-se no exercício da docência na Educação Básica. Assim, propõem-se reflexões sobre sua realização como ensino remoto. Trata-se de um artigo decorrente de reflexões enquanto professoras de licenciatura e análise de proposta de reorganização curricular de 2002 até a atual adoção do ensino remoto tanto na Educação Básica quanto Superior. Como resultados, apresenta-se a etnografia virtual como uma das composições curriculares que preservam o estágio supervisionado como componente da docência.
The effect of job satisfaction on turnover intentions in Star Hotel Semarang
Authors: Pangarso Astadi
Published: October 2020

This paper investigates the effect of job satisfaction on a turnover intention at the Star Hotel Semarang. We use 113 respondents using a non-probability sampling method at the Star Hotel Semarang. Using linear regression, we found the negative relationship between job satisfaction and turnover, suggesting a problematic association between job satisfaction and turnover intention. Therefore, our result suggests that other factors could be the obstacles to job satisfaction, such as the nature of the employee's work that was not under the job description, too strict supervision by the superiors, and a very long time to obtain the job promotion.
Do parents receive their educational investment results? Indonesian case
Authors: Purwanto Edy
Published: October 2020

Aside from identifying the determinants of transfers from children to parents in developing countries like Indonesia, this paper's primary purpose is to examine the effect of education level attainment on the amount of transfer from children to parents. We use the Indonesia Family Life Survey (IFLS-5) data, which covers approximately 34,000 adult individual respondents. Out of all respondents, 16,016 observations met the sample criteria of aged 15 years and older who have parents living outside the household. The result shows that 75% of children provided assistance to parents in the form of money, goods, or labor/time within a year preceding the survey. The average money transfer per year is IDR 1,030,000 (approximately 70 USD), goods transfer worth IDR 303,000 (approximately 20 USD, and 16 days of labor. The result from logistic regression analysis identifies that the determinants of transfers from children to parents are some of the children's characteristics such as education, age, marital status, work, income, and living in urban regions. In addition, from the parent's perspective, parents' characteristics that affect the transfer amount are age, health condition, and widow status.
Working capital management, company performance, and funding barriers on Indonesian Firms
Authors: Handoko Liza , Violeta Chessia
Published: October 2020

The purpose of this study is to examine the relationship between investment in working capital measured by trade credit and corporate performance in 463 companies in Indonesia between 2007 and 2017. This research confirms the non-linearity inverted U shape of the link between working capital and corporate performance. It suggests that there is an optimal point of investment that is beneficial for the company. This research also examines the impact of financial constraint and investment level on working capital. Our finding shows that companies that experience financial constraints have lower investment levels than those without financial constraints. 
Keeping rural children’s hope to stay in the Senior High School through conditional cash transfer: An Indonesian case
Authors: Susilo Hendrawan , Wahyudi Setyo Tri
Published: October 2020

Although the government has allocated cash transfer programs to reduce poverty and improve the education sector, the participation of senior high schools in rural areas in Indonesia is still meager.  This research investigates the relationship between conditional cash transfers in Indonesia (Program Indonesia Pintar–PIP and Program Keluarga Harapan–PKH) with high school participation in children in Rural Indonesia. Using the 2018 socioeconomic survey data released by BPS, we found that children benefited from PIP children had a greater opportunity to participate in high school compared to those who did not. On the other hand, children from PKH beneficiary have a lower chance of attending high school, compared to those who come from families who do not receive PKH. Although conditional cash transfers generally have a positive effect on children's school participation, the success of conditional cash transfers relies on the knowledge of the people about the importance of children's education investments, simple program schemes, secure payment schemes, and efficient and effective technology-based controls.
The effect of work experience and rigidity on the escalation of commitments in investment decisions
Authors: Susilojati Ign. Advent , Hidayat Widi , Wihadanto Ake
Published: October 2020

Escalation of commitment is a form of cognitive bias that has characteristics where decision-makers tend to increase their commitment to an unfavorable investment. This study aims to prove the demographic factors of decision-makers such as work experience and rigid thinking as determinants of escalation of commitment. This research applies a 2 x 2 factorial experimental research design with a case study as an instrument of investment decision making. The participants of this experiment were regular undergraduate students as a proxy for inexperienced decision-makers and non-regular undergraduate students (executive class) as experienced proxy for decision-makers. Participants were selected using a purposive sampling technique with the adequacy criteria for General Point Average (GPA) above 3.00 and have attended and passed the Financial Management course and Theory of Decision Making course. This research uses two-ways ANOVA with a significance level of 5%. Using total 64 respondents, the results showed that work experience and rigid thinking have a significant effect on the escalation of commitment. This study also proves that the interaction between work experience and the rigidity of the decision-making mindset does not affect the level escalation of commitment.
Overtime risk preference and its determinants: Evidence from Indonesia
Authors: Indra Purnama Muhammad Yusuf , Ikhsan Nugroho Linggar
Published: October 2020

This research aims at examining the potential determinants of overtime risk preference in Indonesia–one of the most diverse countries in the world. We used household and individual data as well, taken from the fourth and fifth wave of the Indonesia Family Life Survey (IFLS). The risk aversion of the individual was observed and elicited using hypothetical gambling questions. From the result of Ordinary Least Square (OLS) estimation, we find preliminary evidence that there is a decrease in risk-aversion among individuals over time. However, there is little evidence that catastrophe will alter risk choice as a proxy for a significant life event. Furthermore, our empirical finding also revealed that risk tolerance is motivated not only by demographic factors but also by the education level and individual’s time preference.

 

 

 

 

 

 
Aprendizagem baseada em projetos para a língua inglesa
Authors: Belém Breno , Dos Santos Érica
Published: October 2020

O objetivo principal deste trabalho é abordar o ensino-aprendizagem da língua inglesa através da proposta de ensino denominada aprendizagem baseada em projetos. Será visível que tal proposta possui potência para transformar a maneira de ensinar uma determinada língua, proporcionando assim, práticas pedagógicas significativas no ambiente escolar. Ademais, neste trabalho será proposto um projeto pedagógico com foco no teatro que poderá servir como fator motivacional na aprendizagem da língua inglesa, pois muitos alunos perdem o interesse por se depararem com aulas monótonas, tradicionais e desmotivadoras. Neste sentido, ao propor um projeto que envolva os alunos, bem como promova a interação e socialização dos mesmos, o professor poderá criar condições de uma aprendizagem mais significativa. Sendo assim, é possível que, através de propostas de projetos que abordem assuntos de interesse dos alunos, o professor poderá tornar suas aulas mais significativas. Espera-se, assim, que a aprendizagem da língua inglesa, a partir da integração de professor e alunos, possa criar condições para que emerja a motivação necessária para que os alunos possam aprender a língua inglesa.
A study on depression of the elderly with different sleep quality in pension institutions in Northeastern China
Authors: Zhang Jun , Zhang Yingying , Luan Zhenggang , Zhang Xiujie , Jiang Haoran , Wang Aiping
Published: October 2020

Background: China owns he largest aged population in the world, and the elderly adults who live in pension institutions are more likely to suffer from mental disorders than other elderly adults. The purpose of this study is to discover the risky factors of depression among nursing home residents with various sleeping quality.Methods: We conducted a cross-sectional study in Northeastern China from May to September in 2017 using multistage sampling method and 507 elderly people without cognitive impairment in six pension institutions were interviewed. The Pittsburgh Sleep Quality Index (PSQI) and Geriatric Depression Scale (GDS) were adopted to collect the information of sleep quality and depression. We used logistic regression to analyze the factors influencing depression among the elderly adults with poor or good sleep quality.Results: The overall depression rate among elderly adults was 21.7%. The logistic regression analysis revealed that marital status, chronic disease, regular exercise, physical ache, filial piety and chewing ability had significant effects on the depression of the elderly with good sleep quality. Loneliness, self-caring ability, chewing ability and chronic diseases had significant effects on depression of the elderly with poor sleep quality. Conclusion: The prevalence of depressive symptoms in the elderly is not high. However, sleeping quality distinguishes root causes on elderly adults depression. Therefore, the risk factors of depression among elderly adults should be analyzed separately.
SARFIMA model prediction for infectious diseases: application to hemorrhagic fever with renal syndrome and comparing with SARIMA
Authors: Qi Chang , Zhang Dandan , Zhu Yuchen , Liu Lili , Li Chunyu , Wang Zhiqiang , Li Xiujun
Published: October 2020

Background: The early warning model of infectious diseases plays a key role in prevention and control. Our study aims to using seasonal autoregressive fractionally integrated moving average (SARFIMA) model to predict the incidence of hemorrhagic fever with renal syndrome (HFRS) and comparing with seasonal autoregressive integrated moving average (SARIMA) model to evaluate its prediction effect. Methods: Data on notified HFRS cases in Weifang city, Shandong Province were collected from the Disease Reporting Information System of the Shandong Center for Disease Control and Prevention between January 1, 2005 and December 31, 2018. The SARFIMA model considering both the short memory and long memory was performed to fit and predict the HFRS series. Besides, we compared accuracy of fit and prediction between SARFIMA and SARIMA which was used widely in infectious diseases.Results: Model assessments indicated that the SARFIMA model has better goodness of fit (SARFIMA(1, 0.11, 2)(1, 0, 1)12: Akaike information criterion (AIC):-631.31; SARIMA(1, 0, 2)(1, 1, 1)12: AIC: -227.32) and better predictive ability than the SARIMA model (SARFIMA: root mean square error (RMSE):0.058; SARIMA: RMSE: 0.090).Conclusions: The SARFIMA model produces superior forecast performance than the SARIMA model for HFRS. Hence, the SARFIMA model may help to improve the forecast of monthly HFRS incidence based on a long-range dataset.
Treatment response lowers tumor symptom burden in recurrent and/or metastatic head and neck cancer
Authors: Hecht Markus , Hahn Dennis , Wolber Philipp , Hautmann Matthias G. , Reichert Dietmar , Weniger Steffi , Belka Claus , Bergmann Tobias , Göhler Thomas , Welslau Manfred , Große-Thie Christina , Guntinas-Lichius Orlando , Gruen Jens von der , Balermpas Panagiotis , Orlowski Katrin , Messinger Diethelm , Stenzel Karsten G. , Fietkau Rainer
Published: October 2020

Background: Head and neck squamous cell cancer (HNSCC) frequently causes severe symptoms that may be reduced, when the tumor is successfully treated. The SOCCER trial studied the association of treatment response with patient reported tumor symptom burden in first line treatment of recurrent and/or metastatic HNSCC.Methods: In this prospective, multi-center, non-interventional trial patients were treated either with platinum-based chemotherapy and cetuximab or radiotherapy and cetuximab. Tumor symptom burden was assessed every four weeks with a questionnaire containing ten visual analogue scales (VAS, range 0-100), which were summarized to the overall VAS score. Results: 470 patients were registered in 97 German centers. A total of 315 patients with at least the baseline and one subsequent questionnaire were available for analysis. Changes in the VAS score were rated as absolute differences from baseline. Negative values indicate improvement of symptoms. The overall VAS score improved significantly at the first post-baseline assessment in responders (-2.13 vs. non-responders +1.15, p=0.048), and even more for the best post-baseline assessment (-7.82 vs. non-responders -1.97, p=0.0005). The VAS for pain (-16.37 vs. non-responders -8.89, p=0.001) and swallowing of solid food (-16.67 vs. non-responders -5.06, p=0.002) improved significantly more in responders (best post-baseline assessment). In the multivariable Cox regression analysis, worse overall VAS scores were associated with worse overall survival (hazard ratio for death 1.12 per 10 points increment on the overall VAS scale, 95% CI 1.05-1.20, p=0.0009)Conclusion: In unselected patients beyond randomized controlled trials, treatment response lowers tumor symptom burden in recurrent and/or metastatic HNSCC. Trial registration: ClinicalTrials.gov, NCT00122460. Registered 22 Juli 2005, https://clinicaltrials.gov/ct2/show/NCT00122460
Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats
Authors: Ilbay Gul , Balikci Aymen , Kokturk Sibel , Yilmaz Melda Yardimoglu , Ates Nurbay
Published: October 2020

Background

In previous studies, it has been shown that in early developmental period, the high level of tactile stimulations prevent absence epilepsy development and comorbid depression in Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rats with absence epilepsy. The aim of our study is to examine the effects of neonatal tactile stimulatons on the brain structures that previously defined as the focus of epilepsy in the rat brain with genetic absence epilepsy.
Results

In the present research, morphology and density of dendritic spines were analyzed in the somatosensory cortex (SoCx) in WAG/Rij rats with absence epilepsy, sensory experienced WAG/Rij rats (tactile-stimulated and maternal separated) and healthy Wistar (non-epileptic) rats. To achieve this, a Golgi-Cox method was used. Dendritic spine number in layer V of the SoCx has been detected significantly higher in adult WAG/Rij rats at post natal day 150 in comparison to non-epileptic adult control Wistar rats (p < 0,001). Moreover, quantitative analyses of dendrite structure in adult WAG/Rij rats showed a decrease in dendrite spine density of pyramidal neurons of SoCx which occurred in early neonatal exposure to maternal separation (MS) and tactile stimulation (TS) (p < 0,001).
Conclusions

Our findings provide the first evidence that tactile stimulations during the early postnatal period have a long-term impact on dendrite structure in WAG/Rij rat’s brain and suggest a reduction in dendrite spine density is linked to absence seizure reduction.
Real-world Treatment Patterns of Lung Cancer- experience of Resource Restricted Country
Authors: Kiladze Ivane , Mariamidze Elene , Jeremic Branislav
Published: October 2020

Background:Lung cancer (LC) continues to be a significant worldwide public health issue. In recent years there have been several publications addressing specifics of LC worldwide, but none concerning Georgia- country with high number of smoking population and LC cases. We conducted the first study in Georgian population, that aims current LC practice.Methods: The aim of the study was to provide an overview of treatment of LC, with discussion situation in this field and indicating the future strategies for improved cancer care in the country. Medical, radiation and surgical oncologists providing treatment of LC in main hospitals (n=13) over the country, filled questionnaire that addressed specific information regarding the treatment aspects of LC reflecting current surgical aspects, systemic treatment and radiotherapy (RT). ResultsThere is no national screening program, while radiologic imaging is readily available. The vast majority of patients in the country present with advanced stages at diagnosis and they are treated with systemic therapy and/or RT. The surgical treatment is largely underutilized with the differences being observed among surgeons on the optimal timing and the extent of surgery, as well as role of surgery in specific clinical situations.Improved health care system, well equipped hospitals, availability of many anticancer drugs and existence of modern RT technology, are coupled with slow appearance of country-adapted guidelines and protocols as well as enforcing MDT meetings.There is limited access to expensive novel agents, psychological support and high quality palliative care. ConclusionsThere is still much work to be done, with all above steps considered mandatory to improve effectiveness and quality of care of LC patients.
Biogas Potential From Slaughterhouse Wastes at Ambient Temperatures in Lira Municipality of Northern Uganda
Authors: Kavuma Chrish , Ekwar Isaac , Nabaterega Resty , Lwanyaga Joseph Ddumba , Sserumaga Paul
Published: October 2020

The generation of biodegradable solid waste and wastewaters is characteristic of all slaughterhouses including the Lira Municipality slaughterhouse (LMS) in northern Uganda. However, the LMS is not properly designed to handle and manage the ever-increasing biodegradable solid waste and wastewater. The wastes discharged from LMS, contain reasonable amounts of paunch, fat, grease, undigested food, diluted blood, suspended material, urine, loose meat and soluble protein. The lack of a properly designed slaughterhouse in Lira Municipality, needed to manage and handle the waste has resulted in the discharge of the waste into the environment, leading to pollution of water sources, outbreaks of diseases, and production of unfavorable odors. The objective of this study was to investigate the biogas potential of the LMS biodegradable solid waste and wastewaters at ambient temperatures. The waste was quantified based on Measurement at the point of generation method. Representative samples were characterized for biogas potential. Five treatments of the waste replicated three times were anaerobically digested in 1500mL batch digesters with a working volume of 750mL. Treatment A contained only the inoculum and inoculum in the other treatments B, C, D, and E was approximately 20% of the volume of the substrate. Substrate: water ratio of 1:1, maintained pH of 6.0- 7.0 and retention time of 30 days were used for the study under ambient conditions. On average, 2,597 L, 40 kg and 502 kg of wastewater, cow dung and punch manure respectively were produced from LMS. The quantity and methane content of the biogas ranged from 1029.6 to 3512.7 ml/gVS and 40.6 to 50.4% respectively. Therefore, slaughterhouse wastes are potential sources of biogas production at ambient temperatures.
Integrating Data from Multidisciplinary Management of Malignant Pleural Mesothelioma: A Cohort Study
Authors: Saracino Laura , Bortolotto Chandra , Tomaselli Stefano , Fraolini Elia , Bosio Matteo , Agustoni Francesco , Pozzi Emma , Eleftheriou Dimitrios , Morbini Patrizia , Rinaldi Pietro , Primiceri Cristiano , Filippi Andrea Riccardo , Stella Giulia
Published: October 2020

Background. Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy that most commonly affects the pleural lining of the lungs. MPM has a strong association with asbestos being at least 80% of cases caused by exposure to its biopersistent fibers. Individuals with a chronic exposure to asbestos might refer a 20-40-year latency with no or few symptoms. Such has been the case of Piedmont and Lombardy regions of Italy where industrial production of materials laden with asbestos, mainly cements, has created a large epidemic. Since 2018 in Pavia San Matteo hospital, a multidisciplinary team has been collecting data on over 100 patients with MPM. The main goal of this project is to define and describe an integrated profile for each MPM case at diagnosis by using data mining and partition analysis. Methods. Here we bring together exhaustive epidemiologic, histologic, radiologic data of 88 MPM patients that came to our observation to draw correlations with predictive and prognostic significance. Results. Overall, the median survival (OS) was of 15.6 months. Most patients presented with pleural effusion, irrespective of disease stage. Quite unexpectedly, no statistically significant association had been demonstrated between OS and TNM disease stage at diagnosis. Although average OS is similar in male and female patients, partition analysis of data underlined a significant differential hierarchy of predictor categories based on patient gender. In never smoker female patients, full chemotherapeutic regimens are associated to better outcomes. Moreover, within respect to second line treatments, vinorelbine emerged as the most advantageous choice but only in females, whereas in the male subgroup no statistically significant differences resulted between gemcitabine and vinorelbine. Conclusions. Multidisciplinary approach to MPM is thus mandatory to define better therapeutic approaches, personalize the management and improve patient outcomes.
mRNAsi Index-based Integrative Analysis for the Identification of New Prognostic Models for Ovarian Cancer
Authors: Pan Xue , Ma Xiaoxin
Published: October 2020

Ovarian cancer (OC) has the highest mortality rate among all female reproductive system malignant tumors worldwide. In this study, we aimed to investigate OC from several perspectives by using machine learning. Our results showed that the mRNA expression-stemness index (mRNAsi) is closely related to clinical characteristics of OC patients, as OC patients with venous or lymphatic invasion had higher mRNAsi score compared to patients with no invasion. Furhter grade 3/4 patient group had higher mRNAsi scores compared to the grade1/2 group. We also found that mRNAsi is closely related to immune infiltration in OC. We also built a competing endogenous RNA network, which contained 4 miRNAs, 5 lncRNAs, and 1 mRNA, by using Cytoscape based on the differentially expressed genes of the high- and low-mRNAsi groups. Through Lassio regression, we also established a model including 7 lncRNAs and 2miRNAs, which could effectively categorize OC patients into two groups based on the median risk score. We then developed a nomogram model which could effectively forecast the overall survival rate of OC for 1-, 3-, and 5-year period. The models assessed in this study showed potential for clinical application in treatment decisions for OC.
Use of Over-The-Counter Analgesics for Pain and Psychological Distress Among Adolescents: A Mixed Effects Approach in Cross-Sectional Survey Data From Norway
Authors: Jonassen Rune , Hilland Eva , Harmer Catherine J. , Abebe Dawit S. , Bergem Anne Kristine , Skarstein Siv
Published: October 2020

Background: Over-the-counter analgesics (OTCA) such as Paracetamol and Ibuprofen are frequently used by adolescents, and the route of administration and access at home allows unsupervised use. Psychological distress and pain occur simultaneously and are more common among females than among males. There is a dynamic interplay between on-label pain indications and psychological distress, and frequent OTCA use or misuse can exacerbate symptoms. No studies have to date provided an overview of frequent OTCA use in a larger population-based study. The current study used survey data to explore associations between and the relative predictive value of on-label pain indication and measures of psychological distress, together with sex differences for weekly OTCA use.Methods: This study included 349,528 adolescents aged 13-19. The data was collected annually between January 2014 and December 2018 as part of the Norwegian Young Data survey. Performance analysis was conducted to explore the relative roles and associations between on-label pain indication and psychological distress in weekly OTCA use. A mixed-effects logistic regression model was used to explore the unique contributions from four domains of on-label pain indication and psychological distress as measured by a combined measure of anxiety and depression (HSCL-10) and peer-bullying involvement as victims or bullies.Results: Thirty percent of females and thirteen percent of males use OTCA weekly. Headache is the strongest on-label pain predictor of weekly OTCA use, followed by abdominal pain. Depression and anxiety are the strongest psychological predictor of weekly OTCA use, and higher symptom levels and being female increase the strength of this association. Anxiety and depression also predict weekly OTCA use after controlling for physiological pain.Conclusions: Sex, pain and anxiety and depression are inter-correlated and strong predictors of frequent OTCA use. Frequent OTCA use in the context of psychological distress may be a form of self-medication that can exacerbate symptoms and decrease psychosocial function. Longitudinal studies that explore causal trajectories between frequent on-label OTCA use and psychological distress are required. OTCA use among adolescents, and particularly among females, with anxiety and depression should be administered with caution and closely monitored.
Closed-loop optogenetic control of normal and pathological network dynamics
Authors: Zaaimi Boubker , Turnbull Mark , Hazra Anupam , Wang Yujiang , de Souza Carolina Gandara , Escobedo-Cousin Enrique , Idil Ahmad , Bailey Richard , Tardio Sabrina , Patel Aaliyah , Ponon Nikhil , Hutchings Frances , Kaiser Marcus , Cunningham Mark , Clowry Gavin , LeBeau Fiona , Constandinou Timothy , Baker Stuart , Donaldson Nick , Degenaar Patrick , O’Neill Anthony , Trevelyan Andrew , Jackson Andrew
Published: October 2020

Electrical neurostimulation is effective in treating neurological disorders, but associated recording artefacts generally limit applications to ‘open-loop’ stimuli. Since light does not prevent concurrent electrical recordings, optogenetics enables real-time, continuous ‘closed-loop’ control of brain activity. Here we show that closed-loop optogenetic stimulation with excitatory opsins (CLOSe) affords precise manipulation of neural dynamics, both in vitro, in brain slices from transgenic mice, and in vivo, with anesthetised monkeys. We demonstrate the generation of oscillations in quiescent tissue, enhancement or suppression of endogenous patterns in active tissue, and modulation of seizure-like bursts elicited by 4-aminopyridine. New network properties, emergent under CLOSe, depended on the phase-shift imposed between neural activity and optical stimulation, and could be modelled with a nonlinear dynamical system. In particular, CLOSe could stabilise or destabilise limit cycles associated with seizure oscillations, evident from systematic changes in the variability and entropy of seizure trajectories that correlated with their altered duration and intensity. Furthermore, CLOSe was achieved using intracortical optrodes incorporating light-emitting diodes, paving the way for translation of closed-loop optogenetics towards therapeutic applications in humans.
Apatinib in Treating Clinical and Biochemical Recurrent Ovarian Cancer
Authors: Wang Zhongyu , Huang Yake , Long Ling , Zhou Li , Huang Yan , Gan Lei , Pu Aimin , Li Sufen , Xie Rongkai
Published: October 2020

Background: Biochemical recurrence is defined according to the combined results of serum carbohydrate antigen and image; noteworthily, it generally precedes the onset of clinical evidence. Now treatment strategies of biochemical recurrence ovarian cancer (OC) remain controversial. Apatinib as monotherapy or in combination with other chemotherapeutic agents has shown its effect in the treatment of some advanced malignancies. In our study, we focused on the efficacy of apatinib in recurrent OC, especially its clinical activity in biochemical-only recurrent OC patients. Methods: We retrospectively analyzed clinical material of 41 recurrent patients who had received apatinib monotherapy or apatinib plus chemotherapy between June 2016 and August 2018. Apatinib was administered at a 500 mg daily dose. Response was determined according to measurable disease or serum carbohydrate antigen (CA)-125 levels. Progression-free survival (PFS) was estimated by Kaplan-Meier method.Results: All patients were evaluable, 19 (46.34%) had biochemical relapse and 22 (53.66%) had clinical relapse. The objective response rate (ORR) and disease control rate (DCR) in the overall population were 31.71% and 78.05%, respectively. The median PFS was 7 months (95% confidence interval 5.43-8.57). And in patients with biochemical-only relapse, the median PFS was 6 months, with ORR of 26.32% and DCR of 89.47%. Conclusions: Apatinib is a well-tolerated and effective agent to delay clinical progression of patients with biochemical-only recurrent OC. More important, our study shows the promising prospect for treating OC patients with asymptomatic biochemical relapse.
Bioinformatics Analysis and Insights for The Role of COMMD7 in Hepatocellular Carcinoma
Authors: Peng Xuehui , He Yonggang , Huang Xiaobing , You Nan , Gu Huiying , Dong Rui , Yang Xiaomin , Zheng Lu , Li Jing
Published: October 2020

Background: The tumorigenesis and development of hepatocellular carcinoma (HCC) is a process involving multiple factors. The COMMDs family proteins were reported to play important roles in various disease and cancers including HCC. We previously found COMMD7 acted as a HCC-promotion factor; however, further understanding on COMMD7 was needed. We conducted these bioinformatics analysis for the purpose of comprehensive understanding of the functional role of COMMD7 in HCC.Methods: The bioinformatics analysis of COMMD7 were launched by online platforms including KEGG, GEPIA, cBioportal, Gene Ontology and The Kaplan-Meier plotter. Data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) were downloaded, and the data analysis and processing were conducted by RStudio (version 1.3.959) software.Results: The expression profile results of COMMD7 in TCGA and GTEx database suggested that COMMD7 expressed highly in liver tumor tissues and positively related with poorer prognosis (p<0.01); COMMD7 also contributed to the early development of HCC as its higher expression resulted in progression from stage I to stage III (p<0.01). Based on our previous studies, COMMD7 may target NF-κB signaling and CXCL10 to enhance the proliferation of hepatoma cells so that promoting the development of HCC. Conclusions：This study updates the current studies about the newly recognized roles of COMMD7 in the progression of HCC, summarizing the research progress and prospects of COMMD7 comprehensively, offering an outlook for the future investigation and targeted therapy of HCC.
Within-host Evolution of Acinetobacter Baumannii in Clinical Bacteremia Patients
Authors: Li Henan , Zhang Jiangang , Wang Zhiren , Yin Yuyao , Gao Hua , Wang Ruobing , Jin Longyang , Wang Qi , Zhao Chunjiang , Wang Zhanwei , Wang H.
Published: October 2020

Background: Acinetobacter baumannii colonizing the respiratory tract has been established as an independent risk factor for bacteremia. However, within-host evolution of A. baumannii in bacteremia has not been extensively investigated. Here we performed whole genome sequencing to discover the evolutionary characteristics that accompany the transition from respiratory tract carriage to bloodstream infection in three A. baumannii bacteremia patients.Results: Within-host genetic diversity was identified. A total of twenty-one SNVs were detected. Genic and intergenic evolution occurred particularly in secretion system, DNA recombination and cell motility genes. Intergenic SNVs occurred more frequently than synonymous and non-synonymous SNVs, which indicated potential transcription or translation regulation. Non-synonymous mutations mostly occurred during the transition from the respiratory tract carriage to the bloodstream infection. Isolates of clonal complex 208 (CC208) had lower substitution rate with approximately 10-6 nucleotide substitutions per site year-1, compared with non CC208 isolates (approximately 10-5). We found evidence for the occurrence of recombination in one patient. Gene content showed patient specificity, and isolates within a single host had constrained gene content diversity.Conclusions: Our results indicated that high within-host diversity was driven by rapid mutation rates and limited effect of recombination in A. baumannii from respiratory tract carriage to bacteremia.