bluuebunny/crossref_metadata_2025 huggingface dataset:
Класифікація методів друку та матеріалів друкованої електроніки
Authors: Киричок Тетяна Юріївна , Бардовський Богдан Олександрович
Published: May 2024

У статті подано ґрунтовну класифікацію основ, чорнил і методів друку в контексті друкованої електроніки. У статті систематично класифіковано різні типи основ, включаючи органічні, неорганічні та синтетичні матеріали, серед яких папір, пластик ((поліетилентерефталат (ПЕТ) і поліімід)), текстиль та інші, оцінюючи їхню придатність для друку електроніки. Дослідження також вивчає різні рецептури чорнил, зосереджуючись на їхніх електричних властивостях і сумісності з основами, розглядаються такі матеріали як наночастинки срібла, вуглецеві нанотрубки, графен та інші. Крім того, досліджуються методи друку, які розбиті в класифікації як такі, що потребуютиь використання форми, безформні методи, та недрукарські методи. Серед методів зазначаються струминний, трафаретний, флексографічний друк та інші, аналізуючи їхню застосовність у виробництві електроніки, підкреслюється їхня сумісність з різними матеріалами. У статті визначено найпоширеніші методи друку в друкованій електроніці, відзначено трафаретний друк як найпоширеніший, струминний — за його точність, флексографічний — за швидкість, а глибокий — за високу роздільну здатність. Паперові основи, особливо після обробки, стають стійкими, економічно ефективними варіантами (завдяки своїй низькій вартості порівняно з іншими варіантами), що відповідають екологічним і практичним потребам у різних сферах застосування. Вибір сумісних чорнил — наприклад, срібла для струминного друку на папері або міді для флексографічного друку на пластику — має вирішальне значення для продуктивності пристрою. Складність вибору зумовлює необхідність подальших досліджень методів нанесення елементів для друкованої електроніки. Це дослідження є ключовим для розуміння взаємодії між основами, чорнилами/фарбами та методами друку, керуючи процесом вибору у виробництві друкованої електроніки.
2D сумісна оцінка інформаційних символів і частотної характеристики каналів у системах зв’язку з OFDM технологією
Authors: Мирончук Олександр Юрійович , Шпилька Олександр Олександрович
Published: May 2024

Запропоновано метод двомірної сумісної оцінки інформаційних символів і частотної характеристики каналу в OFDM системах зв’язку на основі фільтра Калмана. Метод складається з двох етапів. На першому етапі виконується ітеративний розрахунок оцінок в прямому і зворотному напрямку по відношенню до масиву оброблюваних даних в частотному напрямку, а також на кожній із підносійних в часовому напрямку. На другому етапі виконується об’єднання отриманих результатів. Кореляційні властивості каналу при цьому вважаються відомими. Виконано аналіз запропонованого методу шляхом статистичного моделювання на модельному прикладі. Результати оцінки параметрів каналу запропонованим методом порівняно з результатами, які дають відомі методи. Проведено розрахунок обчислювальної складності розробленого методу.
Inovasi Media Presentasi Interaktif melalui Pelatihan Pemanfaatan Aplikasi Prezi
Authors: Amalia Dina , Nasyirin Bagus Khairun , Hana Shofiyatul
Published: May 2024

Innovation in development of interactive presentation media through training in the use of Prezi application offers new potential in designing and delivering Pengabdian kepada Masyarakat (PkM) initiatives an interesting and effective way. This PkM aims to provide knowledge and creative presentation skills for MA Miftahul Huda Bulungan Jepara students through a practical and interactive approach using modern technology use Prezi application. The method for this service activity starts from introduction, implementation, and evaluation through pre-test and post-test questionnaires. Expected output will provide participants with the skills to produce more dynamic and interesting presentations, as well as a deeper understanding of the potential of Prezi's interactive features. PkM Gap Analysis in a holistic approach to developing presentation skills, combining technical aspects of using the Prezi application with increasing participant creativity. This innovation brings a training concept that does not only focus on technical skills, but also seeks a transformation in the way participants organize and present presentation materials through the Prezi application. Results of service obtained a pre-test score of 10% and a post-test score of 60%, an increase in scores showing that the training was successful in increasing effectiveness of presentations and enriching participants' experience through use of Prezi features.
 
Abstrak
Inovasi dalam pengembangan media presentasi interaktif melalui pelatihan pemanfaatan aplikasi Prezi menawarkan potensi baru dalam merancang dan menyampaikan inisiatif Pengabdian kepada Masyarakat (PkM) dengan cara yang menarik dan efektif. PkM ini bertujuan untuk memberikan pengetahuan dan ketrampilan presentasi yang kreatif bagi para siswa dan siswi MA Miftahul Huda Bulungan Jepara melalui pendekatan praktis dan interaktif menggunakan teknologi modern berupa aplikasi Prezi. Metode pada kegiatan pengabdian ini dimulai dari pendahuluan, pelaksanaan, dan evaluasi melalui angket pre test dan post test. Luaran yang diharapkan dapat memberikan peserta ketrampilan untuk menghasilkan presentasi yang lebih dinamis dan menarik, serta pemahaman lebih mendalam tentang potensi fitur-fitur interaktif yang dimiliki oleh Prezi. Analisis Gap PkM yaitu terletak pada pendekatan holistik terhadap pengembangan keterampilan presentasi, menggabungkan aspek teknis penggunaan aplikasi Prezi dengan peningkatan kreativitas peserta. Inovasi ini membawa konsep pelatihan yang tidak hanya memfokuskan pada keahlian teknis semata, tetapi juga mengupayakan transformasi dalam cara peserta menyusun dan menyajikan bahan presentasi melalui aplikasi Prezi. Hasil pengabdian diperoleh nilai pre test 10% dan nilai post test 60% kenaikan nilai menunjukkan pelatihan berhasil meningkatkan efektivitas presentasi dan memperkaya pengalaman peserta melalui penggunaan fitur-fitur Prezi.
State COVID-19 Policies and Drug Overdose Mortality Among Working-Age Adults in the United States, 2020
Authors: Wolf Douglas A. , Monnat Shannon M. , Wiemers Emily E. , Sun Yue , Zhang Xue , Grossman Elyse R. , Montez Jennifer Karas
Published: May 2024

Objectives. To identify relationships between US states’ COVID-19 in-person activity limitation and economic support policies and drug overdose deaths among working-age adults in 2020.

Methods. We used county-level data on 140 435 drug overdoses among adults aged 25 to 64 years during January 2019 to December 2020 from the National Vital Statistics System and data on states’ COVID-19 policies from the Oxford COVID-19 Government Response Tracker to assess US trends in overdose deaths by sex in 3138 counties.

Results. Policies limiting in-person activities significantly increased, whereas economic support policies significantly decreased, overdose rates. A 1-unit increase in policies restricting activities predicted a 15% average monthly increase in overdose rates for men (incident rate ratio [IRR] = 1.15; 95% confidence interval [CI] = 1.09, 1.20) and a 14% increase for women (IRR = 1.14; 95% CI = 1.09, 1.20). A 1-unit increase in economic support policies predicted a 3% average monthly decrease for men (IRR = 0.97; 95% CI = 0.95, 1.00) and a 4% decrease for women (IRR = 0.96; 95% CI = 0.93, 0.99). All states’ policy combinations are predicted to have increased drug-poisoning mortality.

Conclusions. The economic supports that states enacted were insufficient to fully mitigate the adverse relationship between activity limitations and drug overdoses. ( Am J Public Health. 2024;114(7):714–722. https://doi.org/10.2105/AJPH.2024.307621 )
Analisis Media Richness Theory Dalam Pemanfaatan Instagram Sebagai Media Komunikasi Laziswaf Unida Gontor Untuk Meningkatkan Filantropi Islam
Authors: Setyaningsih Rila , Hakim Abdul , Romli Syamsur
Published: May 2024

Perkembangan media digital saat ini sangat pesat, sehingga memudahkan hampir semua pekerjaan manusia, salah satunya dalam aksi kemanusiaan atau yang dikenal dengan filantropi. Filantropi adalah bentuk kepedulian seseorang atau kelompok terhadap orang lain. UNIDA Gontor memiliki LAZISWAF sebagai lembaga untuk berbagi dan memperkuat filantropi Islam, khususnya di lingkungan perguruan tinggi pesantren. Tujuan penilitian ini adalah untuk mengetahui bagaimana Analisis Pemanfaatan Instagram Sebagai Media Komunikasi Laziswaf UNIDA Gontor Untuk Meningkatkan Filantropi Islam Dalam Tinjauan Media Richness Theory. Penelitian ini menggunakan metode deskriptif kualitatif. Pengumpulan data dilakukan melalui observasi, wawancara, dan dokumentasi. Analisis data penelitian menggunakan teknik analisis data lapangan Milles dan Huberman yang terdiri dari reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa: Pertama, publikasi konten kurang produktif. Kedua, konten yag diunggah bervariasi. Ketiga, keragaman bahasa. Keempat, tersedianya kontak admin. Kelima, perekaman eksternal belum dilakukan. Keenam, interaksi dengan khalayak telah dilakukan. Penelitian ini diharapkan mampu memberikan kontribusi dalam pengelolaan instagram khususnya di lingkungan perguruan tinggi pesantren.
Strategi Komunikasi Pengurus Rayon dalam Menanamkan Nilai Panca Jiwa terhadap Santri Baru
Authors: Hibatullah Fatkhi , Utomo Bambang Setyo
Published: May 2024

Peran komunikasi sangatlah penting dalam suatu proses kegiatan di dunia ini. Salah satunya dalam lembaga pendidikan, lembaga pendidikan merupakan hal yang sangat penting dalam mencapai keberhasilan proses pendidikan karena lembaga berfungsi sebagai mediator dalam mengatur jalannya pendidikan. Oleh karena itu, peran suatu komunikasi sangatlah penting, karena berperan besar dalam menjalankan proses sosialisasi peserta didik dengan lingkungan masyarakat, untuk tercapainya nilai-nilai pendidikan yang tertanam dalam diri peserta didik. Sebagai salah satu lembaga pendidikan yang berbasis pesantren, Pondok Modern Darussalam Gontor Kampus 2 memiliki sistem dan nilai-nilai pendidikan yang sangat berbeda dari lembaga pendidikan yang lainnya, nilai-nilai tersebut terbentuk pada panca jiwa yang menjadi asas kehidupan bagi setiap orang yang berada di PMDG. Jenis penelitian yang peneliti gunakan adalah penelitian kualitatif dengan metode studi kasus, dengan menggunakan tiga teknik pengumpulan data, yaitu wawancara, observasi, dan dokumentasi. Hasil dari penelitian yang dilakukan, ialah: Pertama,  dari observasi  terdapat 3 masalah yang dihadapi satri baru: pertama adalah pengaruh santri lama, kedua adalah masih adanya kebiasaan dari rumah, dan ketiga adalah gagalnya adaptasi santri baru dengan aktivitas di PMDG Kampus 2. Kedua, pengurus rayon merencanakan suatu strategi komunikasi untuk menanamkan nilai panca jiwa, dengan menggerakan setiap komponen yang bertanggung jawab atas santri baru. Ketiga, pelaksanaan dari setiap strategi komunikasi yang telah direncanakan. Keempat, melakukan evaluasi atas setiap kegiatan yang dilaksanakan dalam menanamkan nilai panca jiwa. Kelima, melaporkan setiap kegiatan yang telah dilaksanakan kepada staf pengasuhan santri dan pembimbing rayon, untuk melihat kekurangan, dan menjadikan setiap kegiatan yang baik sebagai gambaran untuk kegiatan-kegiatan setelahnya.
nERdy: network analysis of endoplasmic reticulum dynamics
Authors: Hamarneh Ghassan , Samudre Ashwin , Gao Guang , Cardoen Ben , Nabi Ivan Robert
Published: May 2024

The endoplasmic reticulum (ER) comprises smooth tubules, ribosome-studded sheets, and peripheral sheets that can present as tubular matrices. ER shaping proteins determine ER morphology, however, their role in tubular matrix formation requires reconstructing the dynamic, convoluted ER network. Existing reconstruction methods are sensitive to parameters or require extensive annotation and training for deep learning. We introduce nERdy, an image processing based approach, and nERdy+, a D4-equivariant neural network, for accurate extraction and representation of ER networks and junction dynamics, outperforming previous methods. Comparison of stable and dynamic representations of the extracted ER structure reports on tripartite junction movement and distinguishes tubular matrices from peripheral ER networks. Analysis of live cell confocal and STED time series data shows that Atlastin and Reticulon 4 promote dynamic tubular matrix formation and enhance junction dynamics, identifying novel roles for these ER shaping proteins in regulating ER structure and dynamics.
A Mathematical Explanation for Why Ratio-Based Isotopic Analyses are Commonly Misleading: Dealing with Confounded Isotopic Ratios
Authors: Moots Kate , Nguyen Christina P. , Nguyen Catherine , Camacho Frank , Lindstrom Dan , Righetti Timothy L.
Published: May 2024

Dozens of preliminary data reevaluations were conducted to verify the ratio-related mathematical theory. Differences in total elements among treatments, times and/or conditions frequently confound interpretation because total element values affect isotopic ratios. Eventually, twelve (six 87Sr:86Sr, three 15N:14N, two 13C:12C and one 34S:32S) well-performed studies were selected as examples. Sr studies: Source evaluations better describe migration patterns for ancient humans and animals, better align speleothem isotopic data with known climate changes, better define the dynamics of isotopic data within a watershed, and better describe sources of soil Sr. N studies: Source evaluations change interpretations for isotopic fractionation in sediments; N tracer treatments on potted plants; and trophic level assignments for different species in a marsh. C studies: Total C confounds 13C:12C data for isotopic fractionation experiments in forest soils and complicates an evaluation of whether past life existed in Martian sediments collected by the Curiosity rover. S studies: Total S also confounds 34S:32S evaluations of the same Martian sediments. We intend to emphasize that source analyses provide better isotopic interpretations than observed ratios in agricultural, biological and environmental studies. Observed isotopic ratio changes do not necessarily reflect source changes. Source analyses improved the Sr, N, C and S isotope evaluations.
Valorization of Diamond Polishing Industry Waste: A Cost-Effective Reservoir for Nanodiamonds and Synthesis of Advanced Epoxy-Diamond Composites
Authors: Bhatt Sandip , Ukani Jash L , Gurjar Kamlesh K
Published: May 2024

Valorizing Diamond Industry Waste: Harnessing Diamond-Enriched (> 80%) Solid Residues for Micro and Nanodiamonds. This study focuses on transforming diamond industry waste into an Epoxy-Diamond Composite, establishing covalent interactions for improving physical strength and achieving uniform nanodiamond distribution. Comprehensive characterization through FTIR, XRD, and SEM, coupled with analyses of heat transfer, tensile strength, and thermal stability, highlights significant advancements in the composite (1 wt% diamond) compared to pure epoxy. Results showcase enhanced physical strength (44%), augmented thermal stability (27%), and increased heat transfer rate (76%). Our approach offers a practical avenue for the effective utilization of industrial waste in real-world applications.
CASE REPORT: Papillary cystic variant of acinic cell carcinoma in the minor salivary gland of the Right cheek
Authors: Sathiah Prasath , Toi Pampa Chi
Published: May 2024

Introduction:
Acinic cell carcinoma is an uncommon neoplasm, with the papillary cystic variant having a fatal outcome. Our knowledge about this variant is limited.
Case Presentation:
Here, we present a case report of a 59-year-old female who presented with right cheek swelling. The biopsy showed tumor cells arranged in a papillary cystic pattern and lined by a cell with an amphophilic cytoplasm and vesicular nuclei. Cells with a focal hobnail appearance were also seen. Tumour cells showed PAS-positive cytoplasmic granules and were positive for alpha-1 antitrypsin and S100. A final diagnosis of a papillarycystic variant of acinic cell carcinoma was made by correlating the morphology with special stain and immunohistochemistry.
Conclusions:
It is essential to recognize this rare variant of Acinic cell carcinomaand look for the factors associated with it for the better management of the patient.
Trial Registration Details and Number- Not applicable
Strain-dependent induction of primary bile acid 7-dehydroxylation by cholic acid
Authors: Vico-Oton Eduard , Volet Colin , Jacquemin Nicolas , Dong Yuan , Hapfelmeier Siegfried , Meibom Karin Lederballe , Bernier-Latmani Rizlan
Published: May 2024

Background
Bile acids (BAs) are steroid-derived molecules with important roles in digestion, the maintenance of host metabolism, and immunomodulation. Primary BAs are synthesized by the host, while secondary BAs are produced by the gut microbiome through transformation of the former. Nevertheless, regulation of microbial production of secondary BAs is not well understood, particularly the production of 7-dehydroxylated BAs, which are the most potent agonists for host BA receptors. The 7-dehydroxylation of cholic acid (CA) is well established and is linked to the expression of a bile acid-inducible (bai) operon responsible for this process. However, little to no 7-dehydroxylation has been reported for other host-derived BAs (e.g., chenodeoxycholic acid, CDCA or ursodeoxycholic acid, UDCA).
Results
Here, we demonstrate that the 7-dehydroxylation of CDCA and UDCA by human-isolated Clostridium scindens strains is induced by CA suggesting that CA-dependent transcriptional regulation of 7-dehydroxylation is generalisable to CDCA and UDCA. In contrast, in the murine isolate Extibacter muris, bai gene expression did not respond to CA or other primary BAs exposure in vitro. E. muris was found to 7-dehydroxylate in vivo.
Conclusions
The distinct expression responses amongst strains indicate that bai genes are regulated differently. CA promoted the 7-dehydroxylating activity in C. scindens strains. Conversely, the in vitro activity of E. muriswas promoted only after the addition of cecal content. The accessory gene baiJ was only upregulated in the C. scindens ATCC 35704 strain, implying mechanistic differences amongst isolates. Interestingly, the human-derived C. scindens strains were also capable of 7-dehydroxylating murine bile acids (muricholic acids) to a limited extent. This study shows novel 7-dehydroxylation activity in vitro resulting from the presence of CA and suggests distinct baigene expression across bacterial species.
Experimental Study of Static Liquefaction Potential Considering the Uncertainty of the Critical State Line (CSL)
Authors: Huang Wenhao , Shamas Youssef , Hoàn Trần Khải , Imanzadeh Saber , Taibi Said , Cursi Eduardo Souza
Published: May 2024

This study aims to explore the undrained shear behavior and static liquefaction potential of sand in both overconsolidated and normally consolidated states. Based on the uncertainty associated with the Critical State Line (CSL) and the state parameter (\(\psi\)) of the samples defined as the current void ratio (es) and the critical void ratio (ec) at the same mean effective stress (p'), the samples were classified into four states: heavily overconsolidation state (HO), intermediate overconsolidation state (IO), lightly overconsolidation state (LO), and normally consolidation state (NC). The latter corresponds to a very loose sand with initial relative density (Dr) of about − 20%. The study findings revealed significant differences in the undrained shear behavior among samples in different consolidation states. Samples in heavily (HO) and intermediate (IO) overconsolidation states exhibited a tendency of initial contraction followed by dilation, with the main difference lying in the presence of a distinct peak strength (qpeak). In contrast, samples lightly overconsolidated (LO) and normally consolidated (NC) only showed a contraction tendency, with the main difference being in residual strength (qresidual). Finally, exploration was conducted into the potential for static liquefaction under different consolidation states. The study found that for overconsolidated samples, their liquefaction potential is mainly controlled by the state parameter (\(\psi\)). As the state parameter increases, the sample's liquefaction potential also increases. Conversely, for normally consolidated samples, their liquefaction potential is determined by the initial mean effective stress (p'0), with the potential decreasing as the initial mean effective stress (p'0) increases.
Synergistic nanocoating: Layer-by-Layer functionalised PCL membranes enhanced with manuka honey and essential oils for advanced wound healing
Authors: Gallo Camilla , Girón-Hernández Joel , Honey Daisy A. , Fox Edward M. , Cassa Maria Antonia , Tonda-Turo Chiara , Camagnola Irene , Gentile Piergiorgio
Published: May 2024

Chronic wounds represent a significant global health concern, statistically impacting 1–2% of the population in developed countries throughout their lifetimes. These wounds cause considerable discomfort for patients and necessitate substantial expenditures of time and resources for treatment. Among the emerging therapeutic approaches, medicated dressings incorporating bioactive molecules, including natural compounds, are particularly promising. Hence, the objective of this study was to develop novel antimicrobial dressings for wound treatment. Specifically, polycaprolactone membranes were manufactured using the electrospinning technique and subsequently coated with natural polyelectrolytes (chitosan as a polycation and a mixture of manuka honey with essential oils nanoemulsions as a polyanion) employing the Layer-by-Layer assembly technique. Physico-chemical and morphological characterisation was conducted through QCM-D, FTIR-ATR, XPS, and SEM analyses. The results from SEM and QCM-D demonstrated successful layer deposition and coating formation. Furthermore, FTIR-ATR and XPS analyses distinguished among different coating compositions. The coated membranes were tested in the presence of fibroblast cells, demonstrating biocompatibility and expression of genes coding for VEGF, COL1, and TGF-β1, which are associated with the healing process (assessed through RT-qPCR analysis). Finally, the membranes exhibited excellent antibacterial activity against both Staphylococcus aureus and Pseudomonas aeruginosa, with higher bacterial strain inhibition observed when cinnamon essential oil nanoemulsion was incorporated. Taken together, these results demonstrate the potential application of nanocoated membranes for biomedical applications, such as wound healing.
A Systematic Review Focused On Understanding the Effects of Modifiable Factors in Patients who Suffer from Chemotherapy Induced Cognitive Impairments or “Chemobrain”
Authors: Sharafkhaneh Saba , Meshkati Negin , Khan Azeem , Shepherd Hannah
Published: May 2024

Background
As the prevalence of cancer survivors increases, there have been increased reports of chemotherapy-induced cognitive impairment (CICI). Around 75% of cancer patients experience CICI during or after treatment. From the reported group, up to 35% will have persistent CICI for months to years following their treatments. In this review, the authors focused on modifiable factors (MFs) as variables that can be manipulated to change the impact of CICI on the patient's life. The MFs focused upon psychological factors, sleep, physical activity, and intervention programs. The authors aimed to establish that when certain interventions that address these MFs are added to treatment plans, it may help to decrease the impact of CICI.
Search Methods:
The authors used the PubMed database to identify articles to be potentially included in the review. A scoping review was conducted to narrow down the topics in relation to CICI. From here, the authors identified a set of factors deemed MFs. Using the inclusion and exclusion criteria, the authors started with 17,242 papers and narrowed down the review to 46 papers. The RoB2 tool from Cochrane Methods Bias was used to conduct risk basis assessment.
Results
The systematic review established that psychological factors, physical activity, and sleep quality/quantity affect the presence and severity of CICI. Furthermore, interventional programs and exercise can help decrease the effects of CICI. Meta-analysis was not conducted due to varying factors (cancer type, treatment type, and assessments conducted) across included studies.
Discussion
Cancer patients and survivors reported more severe CICI when depression, anxiety, fatigue, PTSD, decreased sleep quality and quantity were present. The severity of CICI significantly diminished with the use of physical activity programs, psychological programs, and cognitive training programs; however, the use of herbs, supplements, prescribed medication, Tibetan sound meditation, and EGG feedback showed little to no improvement in CICI. The findings suggest that when CICI is diagnosed at earlier stages, and supplementary interventions (medications, exercise programs cognitive behavioral therapy) are incorporated into treatment plans, the impact and severity of CICI can be decreased. This study urges more focus be placed on this aspect of chemotherapy treatment due to the increased prevalence of cancer survivors in the population.
Funding: There was no funding provided for this systematic review.
Registration: The study protocol was registered on PROSPERO on Aug 18,2022 (CRD42022349831).
Energy-adjusted dietary inflammatory index is associated with chronic kidney disease-associated pruritus in hemodialysis patients: A cross-sectional study
Authors: Rostami Hossein , Delkhosh Marjan
Published: May 2024

Background
Chronic kidney disease-associated pruritus (CKD-aP) is a common and bothersome symptom among hemodialysis patients. This study aimed to determine the association of energy-adjusted dietary inflammatory (E-DII) index with the risk and severity of CKD-aP in hemodialysis patients.
Methods
This cross-sectional study was conducted on 200 hemodialysis patients. A valid 168-item semi-quantitative Food Frequency Questionnaire (FFQ) was used to assess the usual food intake and calculated E-DII. Yosipovitch Itch Questionnaire was used to assess CKD-aP. Based on the E- DII score, odds ratios, and 95% confidence intervals were calculated for the risk of CKD-aP. Linear regression analysis was used to determine the association between E-DII scores and biochemical parameters, CKD-aP score, and pruritus VAS score.
Results
The continuous E-DII score was significantly associated with the risk of CKD-aP in all three models. (model 1; OR = 1.19 (1.02–1.40), model 2; OR = 1.29 (1.00-1.65), and model 3 OR = 1.41 (1.00-1.98)). in all three models, the linear regression analysis showed a significant relationship between the E-DII score and CKD-aP score, as well as the VAS score (P ≤ .05). However, there was no significant association between E-DII and biochemical parameters (P ≥ .05).
Conclusions
This study provides evidence that higher consumption of a pro-inflammatory diet is associated with an increased risk of CKD-aP in hemodialysis patients. Future studies with prospective and interventional designs are required to clarify the association between this dietary index and CKD-aP in hemodialysis patients.
Survey of mosquito species in intesive pig farms in Hunan province, China
Authors: Zhuo Yu , Li Le-Yan , Zhang Yu , Zhang Xue-Ling , Liu Jin-Hui , Deng Yuan-Ping , Liu Guo-Hua
Published: May 2024

Abstract
Mosquitoes (Diptera: Culicidae) are one of the most studied groups of arthropods worldwide due to their high transmission capacity for pathogens, including viruses and parasites. During June to October 2022, the prevalence of mosquito species in 12 intensive pig farms from 12 representative administrative regions in Hunan province of China was investigated using traps with ultraviolet light. All collected mosquitoes were counted and identified to species according to morphological and molecular methods. A total of 4,443 mosquito specimens were collected in the pig farms, and they represented one family, four genera and nine species. Culex pipiens pipiens (24%) was the most common mosquito species, followed by Armigeres subalbatus (23.4%) and Culex tritaeniorhynchus (20.6%). Phylogenetic analyses based on mitochondrial cox1 sequences revealed all mosquito species from present study grouping into distinct monophyletic groups corresponding to nine known mosquito species with strongly supported. The results of the present investigation have implications for the ongoing control of mosquito infestation in pig farms in Hunan province, China. This is the first report of mosquito populations in intensive pig farms in Hunan province, China.
Impact of migrant remittances on child health in Burkina Faso
Authors: MILLOGO Kalé Julienne , N'GUESSAN Coffie Francis José , ZAHONOGO Pam
Published: May 2024

The increase in migrant remittances in recent years in Burkina Faso may contribute to alleviating household liquidity constraints while improving hygiene and health conditions. Therefore, this article aims to analyze the impact of migrant remittances on child health in Burkina Faso. Data from the 2021 EHCVM-2 were used using the linear regression model with an endogenous treatment effect. The results show that migrant remittances lead to a reduction of 2.598 percentage points in the proportion of children aged 0–5 hospitalized for diarrhea, typhoid, stomach problems and malaria, and a reduction of 2.831 percentage points for children aged 6–18. However, the effect appears to be more pronounced among children aged 6 to 18. It is therefore essential that health reforms take into account the magnitude of remittances, while emphasizing improvements in household living and hygiene conditions. In addition, specific health policies for children aged 6 to 18 would be relevant.
JEL Classifications: F24, I12, P36
Association of Thyroid Hormones with Insulin Resistance in Female Hypertensives with or Without Type II Diabetes
Authors: Olatunji Victoria A. , Olarinoye John K. , Arinde Olufemi W. , Ogunmodede James A. , Ologe Mary O. , Njan Anoka A. , Okwute Patrick G. , Abidoye Adebayo O. , Olatunji Lawrence A. , Olorundare Olufunke E.
Published: May 2024

Purpose
Thyroid function alteration is linked to insulin resistance (IR). Limited and conflicting data exist on the thyroid-IR link in African women with hypertension, in the presence or absence of type 2 diabetes (T2DM). This investigation looks into the connection between free thyronine (FT3), free thyroxine (FT4), T3/T4 ratio, and IR in female hypertensive patients with or without T2DM.
Methods
A cross-sectional study on 122 female participants (≥ 18 years), categorized into three groups: 42 healthy controls, 40 hypertensive (HT), and 40 diabetic hypertensive (HT + DM) patients were recruited. Assessments and comparisons between the groups were made using baseline clinical and biochemical indicators.
Results
Mean waist circumference, systolic, and diastolic blood pressures were significantly higher in HT (p < 0.001) and HT + DM groups (p < 0.0001) compared to controls. Plasma FT3 levels were higher in HT (p = 0.042) and HT + DM (p = 0.012) compared to controls. HT group exhibited a higher T3/T4 ratio than HT + DM (p = 0.016). Mean HOMA-IR values were significantly elevated in HT (p = 0.044) and HT + DM (p = 0.047) compared to controls, with HT + DM having a higher HOMA-IR than HT.
Conclusion
These findings demonstrate that FT3 may be a better predictor of insulin resistance compared to FT4 or T3/T4 ratio in hypertensive females with or without type 2 DM.
Traffic Jams: Music and Traffic Noise Interact to Influence the Vividness, Sentiment, and Spatiotemporal Properties of Directed Mental Imagery
Authors: Prince Jon B. , Delalande Joanna , Ayyildiz Ceren , Herff Steffen A.
Published: May 2024

Music and traffic noise are nearly ubiquitous components of our modern auditory landscape. However, much remains unknown on how they interact in influencing higher-order cognitive processes such as mental imagery. Understanding this influence is important because music is a candidate to support mental imagery-based therapies, and traffic noise is often unavoidable in urban environments. Here, 107 participants performed a directed mental imagery task of imagining the continuation of a journey towards a landmark. Each trial had either silence, traffic noise, music, or combined music and noise. Bayesian Mixed Effects models reveal that compared to silence, participants reported enhanced imagery vividness for music in all conditions. Only music increased positive emotional sentiment of the imagined content, and adding noise to music diminished the effect. The auditory landscape further shaped the physical properties of the imagined content; both music and traffic affected the imagined distances travelled, but only music affected the imagined time travelled. Furthermore, elevated traffic-related themes occurred in both conditions involving traffic noise. Overall, both music and noise can modulate aspects of mental imagery and interact in complex ways to reveal dissociations between imagery components. We discuss practical implications for applied contexts, such as imagery-based therapies.
Opportunities for targeted therapies: trametinib as a therapeutic approach to canine oral squamous cell carcinomas
Authors: Peralta Santiago , Katt William , Balkman Cheryl , Butler Scott , Carney Patrick , Todd-Donato Amy , Drozd Matthew , Duhamel Gerald , Fiani Nadine , Ford Jordan , GRENIER JENNIFER , Hayward Jessica , Heikinheimo Kristiina , Hume Kelly , Moore Elizabeth , Puri Rishi , Sylvester Skylar , Warshaw Sydney , Webb Suzin , White Andrew , Wright Alexandra , Cerione Richard
Published: May 2024

Oral tumors are relatively common in dogs, and canine oral squamous cell carcinoma (COSCC) is the most prevalent oral malignancy of epithelial origin. COSCC is locally aggressive with up to 20% of patients showing regional or distant metastasis at the time of diagnosis. The treatment of choice most typically involves wide surgical excision. Although long-term remission is possible, treatments are associated with significant morbidity and can negatively impact functionality and quality of life. OSCCs have significant upregulation of the RAS-RAF-MEK-MAPK signaling axis, and we had previously hypothesized that small-molecule inhibitors that target RAS signaling might effectively inhibit tumor growth and progression. Here, we demonstrate that the MEK inhibitor trametinib, an FDA-approved drug for human cancers, significantly blocks the growth of several COSCC cell lines established from current patient tumor samples. We further show clinical evidence that the drug is able to cause significant tumor regression in some patients with spontaneously occurring COSCC. Given the limited treatment options available and the high rate of owner rejection of these offered options, these findings provide new hope that more acceptable treatment options may soon enter the veterinary clinic.
Effect of Different Iron-Folic Acid (IFA) Formulations, Doses, and Frequencies on Pregnancy and Neonatal Outcomes compared to Multiple Micronutrients (MMN) among Pregnant Women: A Systematic Review and Meta-analysis
Authors: Srivast Manyata , Gulia Annu , Upadhyay Ashish Datt , Patel Kamalesh Kumar , Sankar Mari Jeeva , Sinha Anju , Kumar Pradeep
Published: May 2024

Background: Iron-Folic Acid (IFA) supplementation during pregnancy is widely recommended to prevent maternal anemia and improve birth outcomes. However, the optimal formulation, dose, and frequency of IFA supplementation remain uncertain. This systematic review and meta-analysis aimed to evaluate the effect of different IFA formulations, doses, and frequencies on pregnancy and neonatal outcomes compared to Multiple Micronutrients (MMN) among pregnant women.Methods: A comprehensive literature search was conducted across PubMed, Google Scholar, Cochrane Library, Scopus, and TRIP databases to identify pertinent studies published up to December 31st, 2023. Outcome measures includes preterm birth (PTB), stillbirths, low birth weight (LBW), small for gestational age (SGA), miscarriage rate (MR), neonatal mortality, and perinatal mortality. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated, and the quality of evidence was assessed using GRADEpro.Results: Among 20 studies comparing IFA to MMN, our analysis showed elevated risk of stillbirth (RR: 1.08, 95% CI: 1.00 to 1.17), SGA (RR: 1.03, 95% CI: 1.00 to 1.05) and LBW (RR: 1.06, 95% CI: 1.00 to 1.12) associated with IFA. However, non-significant risk of PTB (RR: 1.07, 95% CI: 0.98 to 1.16) and MR (RR: 0.98, 95% CI: 0.88 to 1.09) was observed with IFA as compared to MMN. Neonatal mortality and perinatal mortality also did not significantly differ between the two groups. Certain formulations and doses showed trend of risk, particularly in relation to PTB and stillbirth.Conclusions: Our findings emphasize the importance of carefully considering the potential risks and benefits of IFA supplementation in pregnancy, and suggest the need for further research to elucidate the underlying mechanisms driving these associations and to optimize supplementation strategies for maternal and neonatal health.
Combination of intravoxel incoherent motion histogram parameters and clinical characteristics for predicting response to neoadjuvant chemoradiation in Rectal Cancer
Authors: Yang Ao , Lin Li-Bo , Xu Hao , Chen Xiao-Li , Zhou Peng
Published: May 2024

Objective To explore the value of histogram parameters derived from intravoxel incoherent motion (IVIM) for predicting response to neoadjuvant chemoradiation (nCRT) in patients with rectal cancer. Methods 112 patients diagnosed with rectal cancer who underwent IVIM-DWI before nCRT were enrolled in this study, and true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and microvascular volume fraction (f) calculated from IVIM, together with the histogram parameters were recorded. The patients were divided into the pathological complete response (pCR) group and the non-pCR group according to the tumor regression grade (TRG) system. We also divided the patients into low T stage (yp T0-2) and high T stage (ypT3-4) according to the pathologic T stage (ypT stage). Univariate logistic regression analysis was implemented to select independent risk factors, including clinical characteristics and IVIM histogram parameters, and the models for Clinical, Histogram, and Combined Clinical and Histogram were generated respectively by using multivariable binary logistic regression analysis for predicting pCR. The area under the Receiver operating characteristic (ROC) curve (AUCs) were used to compare the diagnostic performance among the three models. Results The values of D_ kurtosis, f_mean, and f_ median were significantly higher in the pCR group (n = 24) compared with the non-pCR group. The value of D*_ entropy was significantly lower in the pCR group compared with the non-pCR group. The values of D_ kurtosis, f_mean, and f_ median were significantly higher in the low T stage group (n=37) compared with the high T stage group. The value of D*_ entropy was significantly lower in the low T stage group compared with the high T stage group (allp < 0.05). ROC curves demonstrated that the Combined Clinical and Histogram model had the best diagnostic performance in predicting the pCR patients with optimal AUCs, sensitivity, specificity, and accuracy (0.916, 83.33%, 85.23%, and 84.82%, respectively). Conclusions IVIM histogram parameters which combined with clinical characteristics showed promising prospects in predicting the pCR patients before surgery.
Comparison of Case-Based and Lecture-Based Learning in Dental Fluorosis Education with Visual Analog Scale Assessment
Authors: Wang Man , Liang Shanshan , Jiang Tao
Published: May 2024

Objective: This study aimed to compare the impact of case-based learning (CBL) versus lecture-based learning (LBL) on dental students' clinical decision-making regarding DF severity using Visual Analog Scale (VAS) scoring
Methods:
Eighty first-year graduate dental students were randomly assigned to either the CBL (n=38) or LBL (n=42) groups. Both groups received instruction on DF diagnosis, with CBL involving small group sessions analyzing real cases and LBL involving traditional lectures. Effectiveness was assessed by presenting 32 dental fluorosis cases with Thylstrup-Fejerskov Index (TSIF) scores ranging from 0 to 7 through slide presentations to both groups for VAS assessment. Five evaluators of each group randomly selected were asked to repeat the rating 2 weeks later. Statistical analysis included two-way ANOVA for group and gender differences, intra-class correlation coefficient (ICC) for reliability, and Spearman correlation coefficients for validity.
Results:
Variations in VAS scores were observed between CBL and LBL groups, with no significant gender impact. Excellent inter- and intra-evaluator agreement was found for VAS scoring in both groups, indicating its reliability. Validation against established indices (such as DI and TSIF) demonstrated strong correlations, with CBL students exhibiting higher correlations.
Conclusions:
CBL enhances students' clinical decision-making and proficiency in DF diagnosis, as evidenced by more consistent and accurate VAS scoring compared to LBL. These findings highlight the importance of innovative educational strategies in dental curricula, with implications for improving training quality and clinical outcomes.
The alleviating effect on the growth, chlorophyll synthesis, and biochemical defense system in sunflower seedlings under cadmium stress achieved through foliar application of humic acid
Authors: Wang Xi , Zhang Jinghui , Shen Jie , Zhang Linran , Wei Peipei , Liu Ake , Song Huifang
Published: May 2024

Background: With the progress of industrialization and urbanization, cadmium (Cd) pollution in farmland is increasingly severe, greatly impacting both the ecological environment and human health. Consequently, sunflowers possess high resistance to Cd stress and great potential for phytoremediation of Cd-contaminated soil. Previous studies have shown that humic acid (HA) effectively mitigates plant damage induced by Cd; however, its alleviating effects on sunflower seedlings under Cd stress remain largely unknown.
Results: In this study, we used four different concentrations of HA (50, 100, 200, and 300 mg/L) to investigate the effects of Cd stress on sunflower seedlings' growth, chlorophyll synthesis, and biochemical defense system through foliar spraying. The results revealed that Cd stress not only reduced plant height, stem diameter, fresh and dry weight, and chlorophyll content in sunflower seedlings but also altered their chlorophyll fluorescence characteristics compared to the control group. After Cd stress, the photosynthetic structure was damaged and the number of PSII reactive centers per unit changed. Application of 200 mg/L HA promotes sunflower seedling growth and increases chlorophyll content. HA significantly enhances antioxidant enzyme activities (SOD, POD, CAT, and APX) and reduces ROS content (O2-, H2O2 and - OH).
Conclusion: The foliar spraying of 200 mg/L HA was found to be the most effective in alleviating Cd stress in sunflower seedlings, improving light energy utilization and antioxidant enzyme activities, while reducing ROS contents. These results may provide a theoretical basis for using HA to alleviate Cd stress in sunflowers.
Altered Expression of microRNAs Implicated in Hematopoietic Dysfunction in the Extracellular Vesicles of Bone Marrow-Mesenchymal Stromal Cells in Aplastic Anemia
Authors: Srivast Jyotika , Kundal Kavita , Rai Bhuvnesh , Saxena Pragati , Tripathy Naresh , Gupta Ruchi , Yadav Sanjeev , Kumar Rahul , Nityanand Soniya , Chaturvedi Chandra Prakash
Published: May 2024

Recently, we have reported that extracellular vesicles (EVs) from the bone marrow mesenchymal stromal cells (BM-MSC) of aplastic anemia (AA) patients inhibit hematopoietic stem and progenitor cell (HSPC) proliferative and colony-forming ability and promote apoptosis. One mechanism by which AA BM-MSC EVs might contribute to these altered HSPC functions is through microRNAs (miRNAs) encapsulated in EVs. However, little is known about the role of BM-MSC EVs derived miRNAs in regulating HSPC functions in AA. Therefore, we performed miRNA profiling of EVs from BM-MSC of AA (n = 6) and normal controls (NC) (n = 6), to identify differentially expressed miRNAs carried in AA BM-MSC EVs. DEseq2 analysis identified 34 significantly altered mature miRNAs in AA BM-MSC EVs. Analysis of transcriptome dataset of AA HSPC genes identified that 235 differentially expressed HSPC genes were targeted by these 34 EV miRNAs. The pathway enrichment analysis of 235 HSPC genes revealed their involvement in pathways associated with cell cycle, proliferation, apoptosis, and hematopoiesis regulation, thus highlighting that AA BM-MSC EV miRNAs could potentially contribute to impaired HSPC functions in AA.
Is inferior border osteotomy beneficial in bilateral sagittal split osteotomy? A retrospective clinical study
Authors: Topan Cihan , Bilge Suheyb , Demirbas Ahmet Emin
Published: May 2024

Background
To investigate the effect of lower border osteotomy on the lingual split pattern and inferior alveolar nerve (IAN) in bilateral sagittal split osteotomy (BSSO).
Materials and Methods
The study comprised 32 patients (64 operated sides) who underwent BSSO due to dentofacial abnormalities. In the mandible, 32 sides (the conventional group) received standard BSSO surgery, while 32 sides (the modified group) additionally received lower border osteotomy. The split difficulty of the mandible, the lingual split pattern, and the recovery status of the IAN were evaluated.
Results
Mandibular split difficulty showed a statistically significant difference favoring the modified group (p = 0.032). The mean numbness level of the modified group following surgery was lower than that of the conventional group (p = 0.019). Although there was no statistically significant difference between the two groups regarding lingual fracture pattern, the rate of type 1 fracture was higher in the modified group (p = 0.089).
Conclusion
The additional lower border osteotomy makes the split procedure easier. The modification resulted in an increased incidence of type 1 lingual fracture pattern. The neurosensory recovery capacity of the IAN in the postoperative period is higher in modified group.
Influence mechanism of grinding surface quality of 20CrMnTi steel on contact failure
Authors: Wang Long , Yang Lijun , Wang Liuying , Tang Xiujian , Liu Gu
Published: May 2024

To reveal the influence mechanism of the grinding surface quality of 20CrMnTi steel components on the tribological characteristics and contact fatigue performance, accelerated tests for sliding friction wear and fatigue damage were carried out, and the damage morphology characteristics were analyzed. Tribological characteristics and contact fatigue performance get worse with increasing surface roughness while getting better with increasing surface microhardness. The surface roughness affects the contact conditions of micromorphology and hydrodynamic lubrication, while the microhardness enhances the plastic deformation resistance. Residual compressive stress is conducive to inhibiting the initiation and propagation of cracks and promoting contact fatigue performance. Additionally, a competing failure mechanism is formed under the synergistic effect of frictional wear and contact fatigue failure, in which various phenomena (mechanical friction, abrasive wear, adhesive wear, and fatigue damage) co-exist. Mechanical friction leads to deformation folding and local stress concentrations, resulting in the generation of microcracks, which propagate along the direction parallel to the contact surface to form pitting. The stress concentration at the edge of micro-pitting pits would further induce the number and propagation length of micro-cracks to increase rapidly, prompting the occurrence of a large area of spalling in the shallow layer. This study is more beneficial to promote the 20CrMnTi steel transmission parts manufacturing products for high precision, low damage, and long life.