bluuebunny/crossref_metadata_2025 huggingface dataset:
Smile designing using recurring esthetic dental proportion and aesthetic pre-evaluative temporary technique with porcelain laminate veneers: a case report
Authors: Nipane Ronika , Sundarkar Pravin , Thombare Bhagyashree , Dammani Brajesh , Wankhade Bhushan , Shambharkar Sonali , Ajmire Samiksha
Published: September 2023

Beautiful confident smile has a positive impact on the psychosocial well-being of patients. Spacing present in the anterior region makes a patient feel dissatisfied with their smile. Over the years, a number of innovative techniques have been described in the treatment of patient having spaces between teeth in the anterior region. However, a less invasive and short-time treatment procedure with satisfactory result is preferred by the patient. Laminates have a unique position in today’s dental practice. These conservative restorations are especially important for young permanent dentitions. Porcelain veneers can be considered to be very much in cosmetic dentistry because they deal innumerable advantages over any previous form of veneering systems. This case report described the technique of closure of spaces between teeth in the anterior region by applying recurring esthetic dental (RED) proportion and aesthetic pre-evaluative temporary (APT) technique for smile designing using laminates. The RED proportion has been stated to be an essential tool for achieving esthetics and harmony in smile. The APT technique facilitated diagnosis, communication, and preparation, providing predictability for the restorative treatment. Limiting the preparation depth to the enamel surface significantly increases the performance of porcelain laminate veneers.
Oral manifestations of Alagille-2 syndrome: a rare case report
Authors: Sharma Arun Dev , Parihar Ajay , Reddy Prashanthi , Mandlik Rashi
Published: September 2023

Alagille-2 syndrome (AGLS-2) is a rare autosomal dominant illness that affects the Notch signalling pathway, with few studies reported in the literature related to dental science. It is recognized clinically, with anomalies of the liver, skeleton, kidneys, eyes, and face manifesting. The JAG1 gene accounts for about 97 percent of instances of Alagille syndrome variation, whereas mutations in NOTCH2 account for only 1 percent. When serum bilirubin levels in children are higher than 30 mg/dl, bilirubin builds up in dental tissue and results in varied greenish-brown dyschromia of the teeth. We discussed the dental findings of a patient diagnosed with NOTCH-2 who sought out dental treatment at the government college of dentistry in Indore, MP (India), complaining of pain and a stain in his teeth with typical features of facial dysmorphism.
Post COVID nocardiosis-an opportunistic enemy
Authors: Sesodia Kulwant , Khosla Pooja , Taneja Vinus , Dessai Rishikesh
Published: September 2023

Nocardia is an opportunistic infection seen mostly in immunocompromised individuals. It has become an important pathogen especially in these post covid times in which multiple individuals had to go through high dose corticosteroid therapy as part of their severe COVID-19 treatment. We present a 62 years old male with diabetes mellitus and hypertension who had previously been hospitalized for a month for COVID-19 and received high dose corticosteroids for the same. He presented again one month later with symptoms of fever and breathlessness and was worked up extensively for infections in which all his investigations came negative. For suspicion of opportunistic pathogen his HRCT thorax was done which showed consolidation and cavitation in lung along with other infective changes. In view of HRCT thorax findings bronchoscopy was done and bronchoalveolar lavage was sent for examination which grew Nocardia beijingensis on culture. Cotrimoxazole was started for the patient and 3 days after the initiation of therapy he became afebrile and was weaned off of oxygen support gradually over next one month.
A rare case of normal erections in a patient with recurrent priapism treated with multiple shunt surgeries and anti-platelets
Authors: Chatterjee Sunayana , Deshmukh Hrishikesh , Bassi Sagar
Published: September 2023

This case report discusses a 23-year-old male with recurrent priapism and its management. Priapism, defined as prolonged and painful penile erection, can lead to severe complications including permanent erectile dysfunction (ED) and penile deformities. The patient presented with priapism lasting 34 hours, despite previous spontaneous resolution of similar episodes. Initial treatment involved blood aspiration and irrigation with epinephrine, but the priapism recurred. Various shunting procedures were attempted, yet recurrent priapism persisted. Discussion highlights the challenge of maintaining shunt patency due to thrombosis and the importance of blood flow through the shunt for healing. The report introduces the notion of pre-operative aspirin and post-operative heparin to prevent shunt closure, though guidelines do not currently support this approach. Prior research suggests aspirin's positive impact on erectile function through enhanced nitric oxide production and platelet inhibition. The report concludes by recommending a treatment protocol involving initial aspiration and irrigation, followed by pre-operative aspirin, shunt surgery, and post-operative aspirin for 6 months to prevent shunt closure. This case emphasizes the need for further studies to validate the efficacy of anti-platelet therapy as part of priapism management.
Effect of Bacilli Calmette-Guerin vaccine on severe combined immunodeficiency patient: a narrative review and proposed workup algorithm
Authors: Joshi Helly M. , Oza Yugam R. , Tousif Meirajuddin J. , Mannava Anjali S. , Shah Jash K. , Gondalia Shrinath V.
Published: September 2023

This systematic review critically investigates the administration of the Bacillus Calmette-Guérin (BCG) vaccine in neonates with severe combined immunodeficiency (SCID). The BCG vaccine, derived from Mycobacterium bovis, is a live attenuated vaccine recognized for its significant role in mitigating the impacts of tuberculosis (TB) in endemic areas. Despite its beneficial effects in controlling TB, safety and efficacy concerns have been raised when the vaccine is administered to SCID patients, who have a severe dysfunction or absence of the immune system. The potential for the vaccine to lead to severe complications due to the immunocompromised state of SCID patients necessitates a comprehensive investigation. To better understand these issues, a thorough literature review was carried out, integrating data from clinical trials and observational studies available on the PubMed database. An extensive review and analysis of 32 relevant articles revealed substantial evidence of complications from BCG vaccination in SCID patients. These findings emphasize the urgency for a more effective pre-vaccination screening process to circumvent potential adverse effects. Given the crucial role of the BCG vaccine in controlling TB, its potential to induce severe complications in SCID patients warrants careful consideration. Therefore, this review proposes an in-depth screening algorithm for newborns before BCG vaccination administration. The goal is to prevent these adverse events, offering critical insights to health policymakers, researchers, and clinicians in the field.
The eyes don't see what the mind doesn't know: discovering monoclonal gammopathy of thrombotic or thrombocytopenic significance
Authors: Mannava Anjali Srikanth , Addanki Raja Narendra Divakar
Published: September 2023

A new scientific advancement in the field of medicine has been made thanks to the collaboration between the university of Michigan health and mayo clinic. A previously undiscovered illness has been named Monoclonal Gammopathy of Thrombotic/Thrombocytopenic Significance (MGTS) as a result of thorough investigation and the convergence of facts. The ramifications of this discovery for medical professionals are considerable, and they may lead to a radical change in how we approach patient care, diagnosis, and treatment.
Political marketing and medical humanities education in political theory
Authors: Chen Jinling , Wang Nan , Yuan Yongfei
Published: September 2023

Policy marketing has a strong theoretical explanatory power and practical governance capabilities, and has become an important policy tool. Applying policy marketing to urban neighbor conflict avoidance has the theoretical necessity and practical possibility. So, in this paper analysis the policy marketing can be applied to issues such as urban neighbor avoidance conflicts. In conclusion we propose that, political marketing faces both opportunities and corresponding challenges.
„Taką mam naturę, że ciągle mi wesoło…” Nazwy osobowe motywowane leksyką z pola znaczeniowego ‘natura ludzka’ jako nośnik znaczeń w przestrzeni literackiej Agnieszki Zimnowodzkiej
Authors: Łuc Izabela
Published: September 2023

W artykule omówiono problem nazw osobowych motywowanych jednostkami leksykalnymi z pola znaczeniowego ‘natura ludzka’ wynotowanych z serii opowiadań dla dzieci Humorki Agnieszki Zimnowodzkiej, których właściwości formalno-kategorialne autorka wyzyskała w przestrzeni literackiej, przypisując im status tekstowych znaczeń. Owe twory rozpatrzono z perspektywy lingwistyki stylistycznej, lingwistyki tekstowej oraz pragmalingwistyki. Analiza nazw omawianego typu odsłoniła sposoby ich wpisywania do przestrzeni literackiej, swoiste dla warsztatu twórczego pisarki tendencje w zakresie nominowania nazw, komponowania ich struktur i zastosowane strategie nazewnicze. Znamienną dla autorki tendencją jest kreacja nazw seryjnych i okolicznościowych, umiejętnie wprowadzanych do (kon)tekstu. Onimy wykreowane przez Zimnowodzką pełnią w serii opowiadań wiele przenikających się funkcji – treściową; aluzyjną, dydaktyczną, ekspresywną, informacyjną, intertekstualną, humorystyczną, kreatywną, metatekstową i wartościującą.
Uniwersytet 4.0 – mit cyfrowej akademii? Refleksja historyczno-komunikologiczna
Authors: Kinal Jarosław , Hess Agnieszka
Published: September 2023

Zmiana społeczna wymuszona rewolucją teleinformatyczną oraz stopniowe skurczenie świata zgodnie z paradygmatem globalnej wioski wywarło wpływ zarówno na postrzeganie, jak i funkcjonowanie uniwersytetu jako instytucji publicznej. Współczesna uczelnia, pomimo wypracowanych w poprzednich dekadach a nawet stuleciach norm i procedur, musi w sposób skokowy dostosować się do wymagań tak społeczeństwa cyfrowego, jak i cyfrowej ekonomii z zachowaniem dotychczasowej tożsamości i unikatowej roli, jaką pełni w strukturze społecznej. Celem niniejszego artykułu jest z jednej strony prezentacja przemian, jakie doświadczyła akademia w perspektywie zmiany społecznej, z drugiej – prezentacja badań własnych dotyczących oceny cyfryzacji procesów zachodzących na uczelniach z perspektywy doświadczenia postcovidowego. W badaniu udział wzięło 433 studentów oraz 133 nauczycieli akademickich zatrudnionych zarówno na etacie, jak i współpracujących z uczelnią na umowy cywilnoprawne.
Lifelong learning a satysfakcja z życia osób po 50. roku życia
Authors: Luty-Michalak Marta
Published: September 2023

W literaturze przedmiotu nie brakuje analiz ukazujących wpływ uczenia się na aktywność zawodową, zarobki, pozycję zawodową itp. Często opisywany jest również wpływ stanu zdrowia czy też aktywności społecznej na odczuwany przez jednostki poziom satysfakcji z życia. O wiele rzadziej spotykamy badania wskazujące na związek uczenia się ze zdrowiem, dobrym samopoczuciem czy satysfakcją z życia. Celem artykułu jest analiza wpływu uczenia się na odczuwaną satysfakcję z życia przez osoby w wieku 50 lat i więcej na podstawie wyników 8 rundy badania SHARE (The Survey of Health, Ageing and Retirement in Europe).
“Le Circostanze per cui dio ci fa passare…” Dalla vita di don Luigi Giussani alla sua concezione dell’educazione
Authors: Fedeli Carlo M.
Published: September 2023

Il contributo intende porre in rilievo, in modo essenziale e sintetico, i principali momenti dell’esistenza di don Luigi Giussani che si sono rivelati particolarmente decisivi per la genesi, il prendere forma e la maturazione della sua concezione dell’educazione. Questi momenti si sono verificati nella vita della sua famiglia, nell’arco di tempo della sua formazione nel Seminario di Venegono, nel periodo dell’insegnamento della religione al Liceo Berchet di Milano e negli anni della maturità e della vecchiaia.

Riflettendo sull’esperienza vissuta ogni volta in tali circostanze, Giussani ha progressivamente delineato una concezione dell’educazione che ha per proprie fondamenta la realtà, l’esperienza, la ragione, la bellezza, la libertà, e che si presenta oggi come valida non più solo per gli adolescenti e per i giovani, ma anche per ogni persona in tutte le età della vita.
Metoda wychowawcza stosowana przez ks. Luigiego Giussaniego
Authors: Skreczko Adam
Published: September 2023

Artykuł przybliża metodę wychowawczą, owoc duszpasterskiego i pedagogicznego doświadczenia ks. Luigiego Giussaniego, kapłana diecezji mediolańskiej i założyciela ruchu Komunia i Wyzwolenie. Dla przejrzystości analizy, wybrano 3 słowa kluczowe, które oddają istotę tejże metody: tradycja, autorytet i weryfikacja. Ujęcie to poprzedzone zostało zwróceniem uwagi na podstawy omawianej metody. Metoda wychowania zaproponowana przez ks. Giussaniego nie przestała być aktualna również dzisiaj.
Echa literatury włoskiej w Zmyśle religijnym ks. Luigiego Giussaniego
Authors: Libertini Rosangela , Chanasová Zuzanna , Wójcik-Cifoletti Monika
Published: September 2023

* Artykuł oryginalny w języku włoskim pt. „Echi della letteratura italiana nell’ opera «Ill senso religioso» di don Luigi Giussani” został opublikowany w Rocznikach Pedagogicznych 15(51) 2023, nr 1, s. 155-168

Niniejszy artykuł analizuje mniej zbadany aspekt twórczości księdza Luigiego Giussaniego, jego styl pisarski, a także metodę analizy tekstów, które autor zna i wspomina w swoich pracach. Ksiądz Giussani nie może być uważany za krytyka literackiego, ale jego głęboka kultura skłania go do poszukiwania tych wszystkich aspektów dzieła literackiego, które są bliskie jego własnemu doświadczeniu i najlepiej odpowiadają na pragnienia i lęki każdego człowieka. Dlatego w tekście mowa jest o spotkaniu z wymienionymi autorami. Tekst odnosi się przede wszystkim do Zmysłu religijnego, natomiast jeśli chodzi o przywołanych poetów nawiązuje się zwłaszcza do pisarzy włoskich. Naszym zamiarem było dokonanie porównania między niektórymi osądami wyrażanymi na temat autorów cytowanych przez nowoczesną i współczesną krytykę z tym, co ksiądz Giussani stwierdza o tych autorach. W tekście sięgnięto do oryginalnych tekstów tam, gdzie było to możliwe.
Basi antropologiche della pedagogia di don Luigi Giussani
Authors: Tempesta Marcello
Published: September 2023

Nel percorso culturale di Luigi Giussani la dimensione pedagogica e la dimensione antropologica appaiono intimamente connesse: l’interrogativo sui principi e sulle forme dell’educazione umana è strettamente correlato a quello sulle dimensioni costitutive e strutturali della persona.

L’esperienza umana appare a Giussani caratterizzata dalla percezione di una originaria dipendenza e dalla presenza di un inesauribile bisogno di significato: da questa consapevolezza deve partire l’opera educativa, come offerta di un rapporto capace di introdurre il soggetto alla scoperta del proprio io e delle dimensioni fondamentali del mondo.

Sulla base di questa impostazione, Giussani formula un pensiero educativo che affronta le principali questioni pedagogiche dell’epoca contemporanea, ripensandole in maniera originale: crescita della persona, relazione tra autorità e libertà, esperienza, conoscenza, complessità, nichilismo.
Przekaz wiary w zsekularyzowanym społeczeństwie na podstawie głównych publikacji ks. Luigiego Giussaniego
Authors: Campagnaro Matteo , Wójcik-Cifoletti Monika
Published: September 2023

* Artykuł oryginalny w języku włoskim pt. „La trasmissione della fede in una società secolarizzata sulla base delle principali pubblicazioni di don Giussani” został opublikowany w Rocznikach Pedagogicznych 15(51) 2023, nr 1, s. 109-126

 

Artykuł przybliża myśl teologiczno-duszpasterską księdza Luigiego Giussaniego, kapłana diecezji mediolańskiej i założyciela ruchu Comunione e Liberazione (Komunia i Wyzwolenie). W szczególności została przeanalizowana zaproponowana przez Giussaniego metoda przekazywania wiary chrześcijańskiej w pluralistycznym i zsekularyzowanym społeczeństwie. Myśl teologiczno-duszpasterska Giussaniego charakteryzuje się jego zamiłowaniem do racjonalności, parezją w pragnieniu przekazania młodym chrześcijaństwa nie moralistycznego, sprowadzonego do nakazu etycznego, ale jako „Faktu”, który się wydarzył, którego można doświadczyć dzisiaj w rzeczywistości wspólnoty kościelnej. Według księdza Giussaniego, aby przekazać wiarę współczesnemu człowiekowi, konieczne jest zaoferowanie duszpasterstwa proponującego wiarę w Chrystusa jako spotkanie estetyczne, które odpowiedziałoby na najgłębsze wymogi człowieka dotyczące piękna, prawdy oraz dobra, i do którego rozumną rzeczą jest przylgnąć. W obliczu antropologicznego problemu nowoczesności adekwatną odpowiedzią, według księdza Giussaniego, może być wiara pociągająca człowieka swoim pięknem, czyli racjonalną poprawnością.
Zmiana przestrzeni edukacyjnej przedszkola do spotkania dziecka z książką
Authors: Andrzejewska Jolanta
Published: September 2023

Celem artykułu jest pokazanie zadań nauczyciela jako osoby odpowiedzialnej za aranżację przestrzeni edukacyjnej w przedszkolu do uczenia się i wprowadzającej przemyślane zmiany w edukacji w zakresie budzenia zainteresowań dzieci książką i literaturą oraz przygotowaniem czytelniczym wychowanków.

Podstawowymi kategoriami analizowanymi w artykule są: zamiana edukacyjna, elastyczna i dynamiczna przestrzeń edukacyjna przedszkola, zainteresowania dziecka książką i literaturą i uczenie się dzieci w przedszkolu.

Wnioski przedstawione w artykule opierają się głównie na przeglądzie literatury przedmiotu i analizie dokumentów, stron internetowych przedszkoli ze zdjęciami kącików książki i opisami działań.

Prezentowane w publikacji rozwiązania edukacyjne pozwalają lepiej zrozumieć zmiany przestrzeni edukacyjnej i konieczne modyfikacje aktywności dzieci w zakresie spotkania z książką w miejscach o wzbogaconym potencjale.
Wspomaganie rozwoju motoryki małej dzieci w wieku przedszkolnym w aspekcie przygotowania do nauki pisania – przykłady dobrych praktyk
Authors: Gandzel Agnieszka
Published: September 2023

W wieku przedszkolnym następuje szybki rozwój dużej i małej motoryki, która odgrywa znaczącą rolę w nabywaniu umiejętności związanych z samoobsługą, a także rysowaniem czy pisaniem. Rozwój motoryki małej to nie tylko kreślenie znaków, ale też dbałość o prawidłową postawę ciała, odpowiednie napięcie mięśniowe, czy czucie ciała. To między innymi o te elementy należy zadbać przygotowując dzieci do czytania i pisania.

Aby nauczyć się pisać, dziecko powinno posiadać określony poziom rozwoju ruchowego, szczególnie w zakresie ruchów rąk i właśnie na tym skupia się niniejszy artykuł. Celem teoretycznym pracy jest poznanie mechanizmów, strategii i technik gwarantujących dobre przygotowanie dziecka czytania i pisania w aspekcie motoryki małej, celem empirycznym – analiza sposobów przygotowywania badanego dziecka do czytania i pisania poprzez wspomaganie, usprawnianie motoryki małej, natomiast celem praktycznym – zastosowanie przygotowanych zabaw, gier i ćwiczeń w edukacji przedszkolaków, jak również dzieci starszych z trudnościami w pisaniu i czytaniu.
Determination of the contrast boundaries of the low velocity zone by analyzing the features of the dispersion curves of the Rayleigh wave velocities based on empirical dependencies
Authors: Efremov R. A. , Serdyukov A. S. , Yablokov A. V.
Published: September 2023

An important application of the multichannel surface wave (MASW) method is seismic safety assessment. The key parameters in the calculation of increments in the input of seismic microzoning are the thickness and average velocity of the soil mass lying on the base of more rigid rocks. To determine these parameters, we propose a new method for constructing horizontally layered models of the upper part of the geological section using the features (positions of extrema of the second derivative) of the dispersion curves of phase velocities of the Rayleigh surface wave, which, as shown by numerical experiments, are associated with the position of contrasting boundaries in the medium under study. (e.g., the boundary between soils and rocks). This approach is much simpler than the problem of recovering a horizontally layered model traditionally solved in the MASW method from a set of phase velocities for a sequence of frequencies and does not require an initial approximation and/or any restrictions on the possible values of the model parameters. In the case of two-layer and three-layer media, our approach is reduced to a simple and fast application of explicit formulas.
Pharmacological Activities of Gongura (Roselle) Leaf: Recent Advances
Authors: Patil Sharanabasappa B. , Rao Neha
Published: September 2023

Gongura (Hibiscus sabdariffa) is an annual herbaceous plant widely used in folklore practice for its leafy vegetable, belonging to the family Malvaceae. Over the past decade, various pharmaceutical and phytochemical studies of this plant has shown significant outcome, which are currently accepted and used in therapeutics. The presence of organic acids in higher quantity enhances the medicinal value of this plant. Activities observed in the deferent parts of the plant, such as diuretic, antihypertensive, antibacterial, antifungal, antiparasitic, antipyretic, anti-inflammatory, antioxidant, anticancer, antiobesity, antidiabetic, antihypertensive, antianemic, and anti-pyreticactivity. Based on the mentioned medicinal significance of H. sabdariffa plant, we planned to review the recent studies of all parts of the plant, their nutritional value, and phytoconstituents.
The Health-Promoting Properties of Seaweeds: Clinical Evidence based on Wakame and Kombu
Authors: Chan Eric Wei Chiang , Kezuka Mio , Chan Hung Tuck , Wong Siu Kuin
Published: September 2023

In this review, the botany, uses, bioactive metabolites, and health-promoting benefits of Undaria pinnatifida (wakame) and Saccharina japonica (kombu) are highlighted. Their clinical evidence is focused on clinical studies conducted in Japan and in other countries. These two species are brown seaweeds (Phaeophyta). In Japan, wakame and kombu seaweeds are popular food items consumed almost daily. Laboratory evidence shows that carotenoids (fucoxanthin and fucoxanthinol), polysaccharides (fucoidan) and sterols (fucosterol) are bioactive metabolites in wakame and kombu. Wakame displays antioxidant, anti-inflammatory, anticancer, antihypertensive, antidiabetic, antiviral, anticoagulant, antiosteoporotic, hepatoprotective, and antiobesity properties. Kombu possesses anticoagulant, antithrombotic, anticancer, hypolipidemic, hypoglycemic, antiobesity, antithrombotic, antiatherosclerosis, renal protective, vascular protective, antioxidant, antimicrobial, anti-inflammatory, immunomodulatory, gut biota regulatory, hypoglycemic, hypolipidemic, and neuroprotective activities. Clinical evidence on the effects of wakame intake was based on eight studies in Japan and eight studies in other countries. Clinical evidence on the effects of kombu intake was based on five studies in Japan. One case study on kombu dealt with severe alopecia areata. Some areas for future research on wakame and kombu are suggested. Information and data used in this review were from databases such as Google, Google Scholar, PubMed, PubMed Central, Science Direct, J-Stage, PubChem, China Academic Journals, and ClinicalTrials.gov.
Application of Quality Risk Assessment and Design of Experiment in Optimizing Chromatographic Method for Estimation of Total Sarsasapogenin from the Roots of Asparagus racemosus Wild
Authors: Shah Hardi , Patel Priyanka , Patel Samir , Raval Manan
Published: September 2023

The roots of the plant Asparagus racemosus (Wild) (family: Liliaceae) are used alone as a lactogenic and general tonic or incorporated as a major ingredient in many herbal and Ayurveda formulations. Shatavarin glycosides containing sarsasapogenin as aglycone were found bioactive, and present in predominantly higher amount. The experiments were planned to develop an analytical method for estimation of total sarsasapogenin from the extract using HPTLC, through a systematic approach after identifying the potential failure modes, termed as critical process parameters to achieve the analytical target profile. The associated risks were mitigated by studying the combined effect of the critical process parameters on area, Rf, and tailing factor corresponding to the sarsasapogenin peak, assigned as critical method attributes. The optimization studies were carried out through Design of Experiment approach and process parameters were finalized to achieve analytical target profile. The developed method could resolve the peak of sarsasapogenin from the hydrolyzed methanolic extract prepared from the root powder using silica gel-backed pre-coated aluminum plates. The optimized mobile phase was Hexane:Ethyl acetate:Formic acid (7.0:1.9:0.35, v/v/v); the plates were subjected to post-chromatographic derivatization using 5% v/v hydrochloric acid solution, and heating of the plats for 3 min at 110˚C. The chromatogram was recorded by scanning the plates in TLC scanner using fluorescence mode at 366 nm. The developed analytical method was found to yield linear response in the range of 40-280 ng/spot. The limit of quantification was determined to be 35.88 ng/spot. The method was found selective, accurate, and robust. The amount of sarsasapogenin was found to be determined using the developed method and found to be 2.31% w/w on dried weight basis from the dried root powder. This is the first report of a systematic approach in estimating sarsasapogenin from Asparagus sp.
The Potential of Herbal Plants and Bioactive β Sitosterol in Circumventing Alzheimer’s Disease – A Review
Authors: Mishra Apoorva , Das Saumya , Kumari Soni , Kanda Anmol , Prabhakar Vishnu
Published: September 2023

Alzheimer’s Disease (AD), a neurological ailment, mostly affects the older population all around the world. Rational therapies show limited efficacy, adverse effects, and poor patient compliance therefore herbal drugs are considered as a suitable supplementation to the drug therapy for the treatment of AD. According to research, herbal drugs reduce symptoms of AD and also improve brain functioning by the inhibition of β amyloid, γ-secretase, and acetylcholine along with the regulation of antioxidants and the activation of α-secretase. Various herbal plants like Salvia officinalis, Bertholletia excelsa, Withania somnifera and Urtica dioica help in slowing down the progression of AD by scavenging the free radicals, inhibiting of lipid peroxidation, β amyloid, and tau phosphorylation. β sitosterol, a phytosterol found abundantly in plants has the ability to cross the Blood Brain Barrier and thus acts as a bioactive constituent in circumventing various neurological disorders. Numerous in vitro and in vivo investigations indicate that β sitosterol shows immunomodulatory, lipid-lowering as well as antioxidant properties. The plant sterol, β sitosterol has the capacity to decrease β amyloid platelet synthesis, indicating that it might be helpful in the treatment of prevention of AD. Treatment with β sitosterol can lessen plaque burden and also enhance spatial learning and recognition ability in patients suffering from AD.
Identification and Quantification of Kaempferol From Ethyl Acetate Fraction of Pluchea wallichiana DC Leaves
Authors: Bera Kinjal , Patel Madhavi
Published: September 2023

P. wallichiana DC, commonly known as camphor weed, is practically used in treatment of inflammatory disorders. Identification of kaempferol was done using High-Resolution Liquid Chromatography-Mass Spectrometry (HRLC-MS). High-Performance Thin-Layer Chromatography (HPTLC) method was performed and validated for the quantification of kaempferol. With a correlation coefficient of 0.997, the linearity range for kaempferol was 200 to 700 ng/spot. The suggested method had a recovery rate between 99.60 and 99.85 %. Limit of detection and Limit of quantification were determined to be 25 and 76.47 ng per spot, respectively. The amount of kaempferol was found to be 7.2% in ethyl acetate fraction of leaves. This is the first report of identification and quantification of kaempferol from P. wallichiana DC through HRLC-MS and HPTLC methods.
Formulation Development and Evaluation of a Polyherbal Suspension Containing Curcuma longa, Ocimum sanctum and Azadirachta indica with Improved Antimicrobial Activity
Authors: R. S. Shivarkar  , S. B. Bhise  , Gupta V. Rama Mohan , N. S. Kulkarni  , M. C. Upadhye
Published: September 2023

A lack of global political will to mobilise resource to fight tuberculosis is major challenge in ending tuberculosis. The polyherbal formulations are best alternative, as they are economic, environmentally friendly and easily available than modern drugs. In present study, a polyherbal suspension with extracts of C. longa, A. indica and O. sanctum was developed and characterized. The developed suspension was found satisfactory with respect to odour, colour, taste, pourability, pH, viscosity, zero microbial count, particle size, percentage ease of disposability, aesthetic characteristic, sedimentation, zeta potential and does not show the crystal growth, polyherbal formulation exhibited significantly inhibited the growth of H37Rv and MIC is also comparable to those of standard agents.
Influence of Nutrients in Microalgae Cultivation by SEM and EDX Evaluation
Authors: Pandya Khevna , Upadhye Vijay Jagdish , Shrivastav Anupama
Published: September 2023

Microalgae have recently attracted a lot of attention on a global level because of their numerous application possibilities in the renewable energy, biopharmaceutical, and nutraceutical industries. Microalgae can be exploited to make biofuels, bioactive medicines and food additives at a low cost and with no environmental harmful impact. The media’s nutritional content affects the development of microalgae. The role that macro- and micro-nutrients play in the cultivation of microalgae is also significant. For microalgae cultivation, a sample of river water was collected, BG11 and Bold Basal Media (BBM) synthetic media were prepared. Observations of microalgae growth were made after 15 days. On samples of raw water and microalgae grown in a lab, Scanning Electron Microscopy (SEM) and Energy-Dispersive X-ray spectroscopy (EDX) were conducted. Raw water and microalgae sample structures were detailed by SEM results, and both samples’ chemical compositions were shown by EDX results. The cultivation of microalgae depends heavily on macro and micro nutrients. The growth of microalgae was accelerated in the presence of nutrients.
Majelis Taklim An-Najah as An Enhancer of the Basic Values of Religion and Spirituality
Authors: Wildan T. , Arrauf Nasution Ismail Fahmi
Published: September 2023

His study aims to find out about the recitation of the an-Najah majelis taklim in Improving understanding of the basics of religion and spirituality located in Sukarejo Village, East Langsa District, Langsa City. The methodology used is a qualitative approach with a descriptive analysis method, while the data collection tools include in-deep interviews, observations, and documentation. Respondents in this study were members of the an-Najah majelis taklim, selected and interviewed to obtain the required data, and analyzed to get research results. The findings of this study that the an-Najah majelis taklim in improving the understanding of the basics of religion can improving the spirituality value of the recitation congregation in the dimensions of belief such as closeness to God, peace of mind, peace of mind, and dimensions of behavior, more obedient in worship, consistent in prayer, ukhuwah and friendship, practice all sunnah practices, have good morals, eliminate all forms of heart disease, always prioritize etiquette to teachers, parents, and the community.
Design and construction of artificial microbial consortia to enhance lignocellulosic biomass degradation
Authors: Vu Vi N.H. , Kohári-Farkas Csilla , Filep Róbert , Laszlovszky Gábor , Ban My Thi , Bujna Erika , Gupta Vijai Kumar , Nguyen Quang D.
Published: September 2023

Cellulose-rich agricultural residues are promising renewable sources for producing various value-added products such as 2nd generation biofuels. However, the efficiency of the bioconversion process is not always satisfactory due to the slow and incomplete degradation of lignocellulosic biomass. An interesting approach would be using microbial communities with high lignocellulose-degrading ability for environmentally friendly pretreatment. This study focused on characterizing the degradation performance of bacteria, fungal, and yeast strains and designing and constructing different microbial consortia for solid-state treatment of wheat bran and wheat straw. The microbial consortia, namely BFY4 and BFY5, contained different bacteria, fungal, and yeast led to high ratios of sugar accumulation ranging from 3.21 to 3.5 with degradation rates over 33%, owing to more favorable hydrolytic enzyme activities and improved reducing sugar yield during the process. After 72 h, the highest FPase (0.213 IU/gds) and xylanase (7.588 IU/gds) activities were also detected in the wheat straw pretreated by BFY4 and BFY5, respectively, while CMCase activity peaked (0.928 IU/gds) when wheat bran was used as substrate. The amount of released glucose increased during the treatment process when the two substrates were used in the same ratio. Our results indicated that substrate composition also plays an important role in the degradation capacity of mixed cultures. These findings can be instrumental in advancing the primary knowledge required to apply such bioprocesses at the pilot scale.
ANÁLISE DAS ATIVIDADES TURÍSTICAS NOS MUNICÍPIOS SERGIPANOS: 2010-2019
Authors: De Moura Júnior José Severino , De Santana Ribeiro Luiz Carlos , Rodrigues dos Santos Fernanda
Published: September 2023

Este artigo analisa as atividades turísticas nos municípios do estado de Sergipe no período 2010-2019. Para tanto, realizou-se uma análise descritiva das atividades turísticas formais considerando o número de empregos, estabelecimentos e renda média, obtidos por meio da Relação Anual de Informações Sociais (RAIS) do Ministério do Trabalho e Emprego, e o grau de especialização das atividades turísticas a nível municipal (Quociente Locacional - QL), com a finalidade de identificar o nível de importância dessas atividades nas economias locais. Os principais resultados mostram que a oferta turística (formal) em Sergipe é incipiente e concentrada nos municípios litorâneos, que integram o Polo Turístico Costa dos Coqueirais. Esta região é considerada estratégica para o desenvolvimento da atividade turística no estado, consequentemente, é o Polo mais beneficiado por políticas públicas voltadas para o turismo. Portanto, para a desconcentração do turismo em Sergipe, é importante que se criem políticas públicas que consolidem e estimulem o desenvolvimento dos polos turísticos localizados no interior do estado.
Análisis de los mecanismos jurídicos para garantizar el acceso a los medicamentos esenciales protegidos por patentes farmacéuticas
Authors: Gómez-García Carlos A. , Díaz Viera Carlos Felipe , Giraldo Ruiz Jhon Edison
Published: September 2023

Debido a las regulaciones sobre las patentes que recaen en fármacos de carácter esencial y básico, se propone un análisis conceptual del Acuerdo de la OMC sobre los Aspectos de los Derechos de Propiedad Intelectual relacionados con el Comercio (Acuerdo sobre los ADPIC), del derecho a la salud y el acceso a los medicamentos esenciales. Además, se aborda el conflicto existente en la ponderación de los intereses privados y públicos reflejados en el ADPIC y el acceso a los medicamentos esenciales como prestación derivada del derecho a la salud, que causa la desprotección a poblaciones de escasos recursos económicos por el monopolio legal habilitado por dicho acuerdo. Mediante una metodología cuantitativa basada en una revisión bibliográfica, en este artículo se plantea un acercamiento a la problemática principal consistente en la eficacia que poseen los mecanismos jurídicos colombianos habilitados a las poblaciones de escasos recursos para garantizar el acceso a los medicamentos, tales como la acción de tutela, las licencias obligatorias, regulación de precios y políticas públicas en salud. Además, como dicho conflicto concurre en otros países en vía de desarrollo conforme al contexto legal y socioeconómico análogo entre ellos, se comparan las propuestas y alternativas realizadas por estos Estados. El desarrollo jurisprudencial sobre el Derecho a la salud y la protección de los ADPIC ha generado un conflicto que afecta el acceso a los medicamentos esenciales para las poblaciones de escasos recursos. Aunque los mecanismos alternativos como las licencias voluntarias y obligatorias, y la regulación de precios, han incrementado el acceso, la acción de tutela sigue siendo la principal alternativa para garantizar el acceso a los medicamentos debido a sus limitaciones y carencias.
Marco conceptual de los derechos colectivos: de la llamada tercera generación de derechos como derechos fundamentales
Authors: Sánchez Cubides Pedro Alfonso , Higuera Jiménez Diego Mauricio , Saavedra Bautista Claudia Esperanza
Published: September 2023

Los derechos colectivos forman parte de los derechos fundamentales al estar consignados en la Constitución Política de Colombia. En tal sentido, el presente artículo tiene como objetivo realizar una aproximación conceptual a la idea de derechos colectivos, sus características y su concreción en calidad de derechos fundamentales, al igual que estudiar los principales mecanismos con que cuentan los jueces para amparar dichos derechos, entre los que se encuentran el procedimiento contencioso administrativo y las acciones popular, de grupo y de tutela. La metodología utilizada es de carácter descriptiva y se soporta en el método cualitativo. No obstante, la positivización de los derechos colectivos, se concluye que en la práctica existe una relevante brecha entre lo declarativo y lo efectivo en materia de los referidos derechos, razón por la cual los ciudadanos deben hacer uso de recurrente de las señaladas acciones constitucionales para obtener la protección y garantía de tales facultades.
La naturaleza titular de derechos como mecanismo de protección integral
Authors: Zapata Galvis Juliana , Rivera Herrera Karol Vanessa , Medina Medina Yanine Alejandra , Rojas Bravo Brandon Steven , Melo Quintero Brandon Stiven
Published: September 2023

Desde 2016, con el histórico fallo de la Corte Constitucional que reconoció al río Atrato como sujeto de derechos, en Colombia se han reproducido fallos de tutela en los que, invocando este precedente jurisprudencial, se han reconocido con personalidad jurídica a otros sujetos de la naturaleza. En este artículo se analizan este y otros fallos que reconocen dichos derechos: a los Ríos Magdalena y Cauca, al Páramo de Pisba y al Parque Nacional Natural Los Nevados. Recurriendo al método hermenéutico, se interpreta y argumenta a favor de la pertinencia de la personalidad jurídica como mecanismo de garantía de las normas ambientales que se vienen infringiendo de forma reiterada en Colombia en perjuicio de los derechos fundamentales y de la naturaleza, causando daños, muchas veces irreversibles, que alteran los ecosistemas y ponen en riesgo la supervivencia de la especie humana y de muchas otras especies en la Tierra. También se reflexiona sobre los criterios que hacen viable la tutela como mecanismo de protección de derechos ambientales; y sobre las órdenes de implementación y seguimiento establecidas en las sentencias para lograr el reconocimiento de la personalidad como mecanismo de protección integral, indagando sobre el grado de implementación que se ha logrado.
The effect of achieving guideline-based target low-density lipoprotein cholesterol levels on mortality in transcatheter aortic valve implantation patients with coronary artery disease
Authors: DEMİR Ömer Furkan , LEVENT Fatih
Published: September 2023

Objectives: The aim of this retrospective study was to evaluate the effects of bringing low-density lipoprotein cholesterol (LDL-C) values to levels in line with guideline recommendations on long-term mortality in patients with a known history of coronary artery disease (CAD), undergoing transcatheter aortic valve implantation (TAVI), and long-term pre-treatment with statins.
Methods: This is a retrospective and observational study of patients undergoing TAVI at a tertiary heart center with a history of CAD and long-term statin therapy. Ninety-nine patients were included in the study. The relationship between LDL-C levels in accordance with the guidelines and 5-year mortality was determined by regression analysis.
Results: When the study population was divided into 2 groups with and without 5-year mortality, LDL-C values were found to be significantly higher in the mortality group (120 mg/dL vs. 93.9 mg/dL, p < 0.001). Parameters associated with the development of 5-year mortality were evaluated with univariate and multivariate logistic regression analysis. LDL-C ≥ 100 mg/dL (OR: 6.59, 95% CI: 2.17-20.01) and LDL-C ≥ 70 mg/dL (OR:3.88, 95% CI: 1.16-12.93) parameters were determined as independent predictors of mortality independent of other parameters.
Conclusions: The most important result obtained in this study is that achieving the LDL-C level targets specified in the guidelines significantly reduces the in-hospital and 5-year mortality rates in patients with a previous history of CAD and statin use and undergoing TAVI. Although all patients included in the study used statins, the mortality rate was significantly higher in patients who did not reach the target LDL-C value.
Assessment of the global and national market for lipid modifying agents: retrospective and innovation
Authors: Lokhmacheva A. V. , Fominykh S. G. , Trubina L. V. , Sikhvardt I. E.
Published: September 2023

Lipid-lowering therapy is one of the most important aspects in the treatment of patients with cardiovascular disease, which is still the leading cause of death in the adult population. Over the past 10 years, fundamentally new lipid-lowering drugs have appeared such as alipogene tiparvovec, mipomersen, lomitapide, evolocumab, alirocumab, bempedoic acid, inclisiran, evinacumab, volanesorsen. In order to update information on the effectiveness and safety of the use of lipidlowering drugs, their consumption in the pharmaceutical market in retrospect and at the present time, a systematic search was carried out in the scientific databases eLIBRARY.RU, PubMed, Embase, ClinicalTrials.gov, the Cochrane Library, Russian State Register of Medicines from 1980 to 2023. Statins remain the main drugs of choice for regular use in violation of lipid metabolism. Fibrates are the drugs of choice in patients with rare forms of hyperlipidemia associated with high triglyceride level. A group of other lipid-lowering drugs has been characterized from the point of view of the mechanisms of action, indications for use, and the availability of registration certificates in the Russian Federation and in the world. The growing interest in ezetimibe in the Russian pharmaceutical market is confirmed by the high growth in the share of local companies in its production as part of the import substitution strategy. It has been established that the drug causes undesirable effects with a small degree of probability as part of combination therapy. Inhibitors of proprotein convertase subtilisin-kexin type 9 (PCSK9) open up new possibilities for the treatment of patients at very high risk of cardiovascular disease. Lomitapide is not registered in the Russian Federation, but since December 2021 it has been included in the list of medicines purchased by the Krug Dobra Foundation to help children with homozygous familial hypercholesterolemia. Since 2022, inclisiran, a drug inhibiting synthesis of PCSK9 with RNA interference, has been approved for use in Russia and is safe in patients with hyperlipidemia and statin intolerance. Thus, in the 21st century, fundamentally new positions have appeared in the group of lipid-lowering drugs, which are examples of biotechnological and gene therapy drugs.
Possibilities of the ultrasound method in the diagnosis of pathology of the septal region. Literature review and clinical cases
Authors: Cherdantseva S. Yu. , Olkhova E. B. , Cherdantseva Yu. E. , Kanailova O. P. , Gorbacheva N. V.
Published: September 2023

Disorder of the formation of the cavum septum pellucidum (CSP) occurs in a wide range of pathologies of the brain. Its identification from 18 to 37 weeks is a necessary rule of prenatal screening, which must also be performed in postnatal studies of premature infants. Unimaged CSP should be considered as a potential indicator of cerebral dysfunction and such severe malformations as agenesis (dysgenesis) of the corpus callosum, holoprosencephaly (HPE), schizencephaly, Aicardi syndrome, hydrocephalus and septo-optic dysplasia (SOD). A special place in the differential diagnosis of unimaged CSP is represented by SOD, lobar HPE, and its mild subtype - septopreoptic HPE. The literature describes the isolated absence of SP, without finding other signs related to HPE or SOD, as a variant of development. However, the neurological outcome in these children varies from normal to delayed development of the nervous system by different degrees, so this statement remains controversial. The article discusses in detail the anatomy, physiology, pathology of the septal region, the role of echographic studies in the antenatal and postnatal periods, and the correlation of the detected changes with the clinical picture.
Morphometric analysis of the structures of the skull according to computed tomography data in children in norm and in dolichocephaly
Authors: Gaibov S. S. , Zakharchyk E. V. , Vorobjov D. P.
Published: September 2023

There is an increased interest in the problem of helping children with skull deformities that occur due to premature closure of cranial sutures and the development of craniosynostosis. Assessment of cranial dysmorphism in skull deformities is often subjective and remains a challenge. Morphometric studies are a significant section that is poorly covered in modern scientific, practical and reference medical literature.Material and methods. The analysis of the data of craniometric measurements, of cephalic index (CI) according to the results of computed tomography in 24 children with dolichocephaly (14 boys, 10 girls) at the age of 7.4 ± 3.2 months (2–12 months) and in the control group of 25 children (15 boys, 9 girls) at the age of 7.2 ± 4.8 months (2–12 months).Results. The data showed significant differences in children in norm and in dolichocephaly. CI shows the ratio of the linear dimensions of the skull in normal and dolichocephaly. The most significant differences were revealed when assessing the distances G-Op, CG-TS, CG-MAI, MAI-MAI, Zg-Zg, Ec-Ec, Br-Ba. CG-TS, CG-MAI, MAI-MAI, Br-Ba reflect deformation of the skull base, and Zg-Zg, Ec-Ec – deformation of the facial skeleton in dolichocephaly.Conclusions. A comprehensive morphometric analysis of the skull structures based on precise anatomical landmarks demonstrated objective differences in the morphology of the skull in children with normal conditions and with dolichocephaly. The data indicate the importance of a comprehensive assessment of changes in the skull for all forms of the skull. Carrying out such an analysis is important for understanding all morphological changes in the skull in health and disease.