bluuebunny/crossref_metadata_2025 huggingface dataset:
Civil Liability and the Challenges of Climate Change: A Functional Analysis
Authors: Hinteregger Monika
Published: November 2017

The most recent efforts under the UN Framework Convention on Climate Change (UNFCCC) to seek redress for loss and damage associated with climate change impacts has triggered the interest in tort law remedies for climate change damage. This article analyses the relevance of tort law for climate change damage from a civil liability perspective. It indicates the positive features of tort law for the protection from climate change (generally available instrument for compensation of losses with considerable preventive effects), but it shows also that civil actions against the emitters of greenhouse gases for the remediation of climate change damage encounter major legal difficulties: choice of jurisdiction, enforcement of claims and some basic shortcomings of substantive tort law (narrow concept of damage, establishment of causation and fault). In order to make tort law an effective instrument for climate protection it must be adjusted to the characteristics of climate change damage. This concerns the attribution of legal standing, especially with respect to pure economic loss, a considerable extension of the right to bring collective action and, in order to solve the problem of the establishment of causation, the comprehensive recognition of proportional liability by national tort laws.The article also shows that tort liability already plays an important role for the remediation of climate change damage. This concerns liability claims against persons or institutions who are legally obliged to protect individuals or objects from harm caused by climate change (public authorities, providers of building services) and against sellers of products or providers of services who do not meet mandatory emission or energy consumption standards. Liability claims against such defendants do not encounter any of the specific problems associated with climate change damage and can serve to prevent climate change related harm.
Estimating Cross-Classified Population Counts of Multidimensional Tables: An Application to Regional Australia to Obtain Pseudo-Census Counts
Authors: Suesse Thomas , Namazi-Rad Mohammad-Reza , Mokhtarian Payam , Barthélemy Johan
Published: November 2017

Estimating population counts for multidimensional tables based on a representative sample subject to known marginal population counts is not only important in survey sampling but is also an integral part of standard methods for simulating area-specific synthetic populations. In this article several estimation methods are reviewed, with particular focus on the iterative proportional fitting procedure and the maximum likelihood method. The performance of these methods is investigated in a simulation study for multidimensional tables, as previous studies are limited to 2 by 2 tables. The data are generated under random sampling but also under misspecification models, for which sample and target populations differ systematically. The empirical results show that simple adjustments can lead to more efficient estimators, but generally, at the expense of increased bias. The adjustments also generally improve coverage of the confidence intervals. The methods discussed in this article along with standard error estimators, are made freely available in the R package mipfp. As an illustration, the methods are applied to the 2011 Australian census data available for the Illawarra Region in order to obtain estimates for the desired three-way table for age by sex by family type with known marginal tables for age by sex and for family type.
Figuring Figures: Exploring Europeans’ Knowledge of Official Economic Statistics
Authors: Vicente Maria R. , López Ana J.
Published: November 2017

Economic issues have been a major concern for Europeans in the last few years. In this context, it is reasonable to suppose that people are aware of the main economic figures regarding Europe. But are they really familiar with them? Do they know what the rates of growth, unemployment and inflation are?

The aim of this article is to explore the level of knowledge of these three economic indicators among Europeans. Several regression models are specified and estimated in order to identify the relationship between an individual’s knowledge and their socioeconomic profile, use of the Internet, perceived importance of economic issues and official statistics and trust in them. Cross-country differences are also assessed.
Crystal structure of Ga0.62(3)Sb0.38(3)Pd3
Authors: Matselko Oksana , Burkhardt Ulrich , Gladyshevskii Roman , Grin Yuri
Published: November 2017

Ga0.62(3)Sb0.38(3)Pd3, tetragonal, P4/mbm (no. 127), a = 5.5036(2) Å, c = 7.9990(3) Å, V = 242.29(3) Å3, Z = 4, Rp
= 0.0168, Rwp
= 0.0291, T = 295 K.
Three Years of Observations on Global Solar Radiation at Mădârjac Weather Station (270 m) - Central Moldavian Plateau
Authors: Sfîcă Lucian , Ichim Pavel , Apostol Liviu , Machidon Ovidiu
Published: November 2017

This study is based on 3 years of hourly observations of global solar radiation (2014-2016), at a new weather station installed in the region of Central Moldavian Plateau, at Mădârjac (47.05°N, 27.25°E, 270 m). The main characteristics of annual, monthly and daily regime of global radiation were emphasized using for comparison similar data from Iașioficial weather station. Smaller annual amount of global solar radiation than those observed in previous studies were observed, reaching 4734 MJ/m2 in Iași and 4454 MJ/m2 in Mădârjac. An altidudinal gradient of global solar radiation close to 140 MJ/m2 was identified for the hilly region of Moldova. Despite the overall higher values in Iași, 30% of days indicates higher values of this parameter at Mădârjac weather station. These results can be used for the evaluation of the photo-voltaic potential in the region, but also to understand the altitudinal differences of solar radiation in the hilly region in Moldavia, since the only long-range actinometric stations from this part of Romania, Iași and Galați, are located at low altitudes.
2006-2012 Land Cover and Use Changes in Romania – An Overall Assessment Based on Corine Data
Authors: Petrişor Alexandru-Ionuţ , Petrişor Liliana Elza
Published: November 2017

Land cover and use changes are an important component of the global changes, and in relationship with their transitional dynamics reflect the impact of socio-economic transition. This study is aimed at exploring the land cover and use changes occurred during 2006-2012 in Romania with respect to their spatial distribution over the regions of development and main transitional dynamics. The results suggest that the main drivers of change are deforestation and urbanization, accounting for 3/4 of all changes, and that the most affected regions are the northwest, southwest, center and northeast ones. Overall, the findings suggest a continuation of the trends from the previous periods, characteristic to transition economies.
Dynamics and Branch Structure of Water Consumptions in the Republic of Moldova
Authors: Petru Bacal , Daniela Burduja
Published: November 2017

The purpose of this research consists in the elucidation of spatial and branch aspects of the water use in the river basins of Republic of Moldova. The main topics presented in this paper are: 1) the dynamics of water use; 2) spatial and branch profile of water use and its dynamics: 3) existing problems in the evaluation and monitoring of water use. To achieve these objectives were used traditional methods of geographical and economic research. Also, the content of the present study is focused on the methodology to elaborate the management plans of hydrographical basins and their chapters on economic analysis of water use in the river basin. of Republic of Moldova.
Tornadoes in the Moldavian Plateau – Between Myth and Reality
Authors: Paraschiv Viorel , Machidon Ovidiu-Miron
Published: November 2017

All those who spent our holidays in the countryside to our gradparents or relatives, we heard about the elders’ stories about storms that rained frogs and fish. I also remember such a story that occured in the villages of Covasna river basin in 1970. The elders were speaking about such a heavy rain accompanied by fish that would have occurred due to an overheating of the active surface in July or August 1946 as well as in 1968 (!). Then, out of the blue, out of the forest, from ESE, black clouds accompanied by thunder and lightning occured, while frogs and fish fell among heavy drops of dirty rain.
Psychological consequences of multiple sclerosis and assistance possibilities
Authors: Neustein Jolanta , Rymaszewska Joanna
Published: November 2017

Multiple sclerosis (MS) is an inflammatory and demyelinating disorder of the central nervous system. It is a chronic, unpredictable and pleomorphic disease, with a variety of symptoms and diverse course, which changes the life of the patient, their family and relatives. Therefore, the analysis of the nature and individuality of psychological issues in MS has become an important aspect for health professionals. Psychological consequences may occur before, during, or after the diagnosis. The adaptation process, mental changes observed in patients and how they live their lives with a chronic disease are very individual in character. The disease and its sequelae are so stressful that they cause dramatic changes which are contrary to the previous development, to the image of self. The quality of life in MS patients is conditioned not only in physical but also in psychological terms; thus there is a necessity to seek treatment, support, and specialist rehabilitation of patients in relation to psychological help. The full rehabilitation program should represent a holistic approach to the patient and include physical, cognitive, emotional, personal, and social aspects.
Shell and Tube Heat Exchanger – the Heat Transfer Area Design Process
Authors: Gužela Štefan , Dzianik František , Juriga Martin , Kabát Juraj
Published: November 2017

Nowadays, the operating nuclear reactors are able to utilise only 1 % of mined out uranium. An effective exploitation of uranium, even 60 %, is possible to achieve in so-called fast reactors. These reactors commercial operation is expected after the year 2035. Several design configurations of these reactors exist. Fast reactors rank among the so-called Generation IV reactors. Helium-cooled reactor, as a gas-cooled fast reactor, is one of them. Exchangers used to a heat transfer from a reactor active zone (i.e. heat exchangers) are an important part of fast reactors. This paper deals with the design calculation of U-tube heat exchanger (precisely 1-2 shell and tube heat exchanger with U-tubes): water – helium.
The Effects of Piezoelectricity Matrix Constants on the Charge of a Thin Membrane
Authors: Kováč Tomáš , Horvát František , Hučko Branislav , Jančo Roland , Musil Miloš
Published: November 2017

This article is devoted to the comparison of the influence of the piezoelectric matrix properties on the magnitude of the resulting charge when a thin piezoelectric membrane of circular cross section, made from aluminium gallium nitride (Al-GaN), is loaded. The size of change of the electric charge was determined by the numerical analysis and the by the change of the properties of the piezoelectric matrix. The matrix constants were obtained from various sources introduced in world databases.
The Analysis of the Usefulness of Welded Meshes to Embankment Reinforcement
Authors: Ćwirko Marcin , Jastrzębska Małgorzata , Kwiecień Sławomir
Published: November 2017

The aim of this paper was to find an answer to the question about the possibility of using steel welded mesh in building the retaining walls of gabion baskets. In light of the currently used gabion structure solutions, among which double-woven mesh is much more popular, the focus was put on the possibility of using welded mesh. A numerical analysis was conducted to examine the behavior of welded and woven mesh subjected to various loads and the results obtained for both types of mesh were directly compared. The maximal displacement in mesh nodes was admitted as the measurement of the system behavior (in the case of both undamaged and damaged mesh).
Non-Isothermal Constitutive Relations and Heat Transfer Equations of a Two-Phase Medium
Authors: Uciechowska-Grakowicz Anna , Strzelecki Tomasz
Published: November 2017

In the case of a two-phase medium – such as the soil, which consists of an elastic skeleton and is filled with pore fluids – stress and strain within the medium are dependent on both phases. Similarly, in the case of heat transfer, heat is conducted through the two phases at different rates, with an additional heat transfer between the phases. In the classical approach to modelling a porous medium, it is assumed that the fluid filling the pore space is water, which is incompressible. In the case of gas, the volume of which is strongly dependent on temperature and pressure, one should take this behavior into account in the constitutive relations for the medium. This work defines the physical relations of a two-phase medium and provides heat transfer equations, constructed for a porous, elastic skeleton with fluid-filled pores, which may be: liquid, gas, or mixture of liquid and a gas in non-isothermal conditions. The paper will present constitutive relations derived from the laws of irreversible thermodynamics, assuming that pores are filled with either a liquid or a gas. These relations, in the opinion of the authors, may be used as the basis for the construction of a model of the medium filled partly with a liquid and partly with a gas. It includes the possibility of independent heat transfer through any given two-phase medium phase, with the transfer of heat between the phases.
Comparison of Some Families of Real Functions in Algebraic Terms
Authors: Filipczak Małgorzata , Ivanova Gertruda
Published: November 2017

We compare families of functions related to the Darboux property (functions having the 𝒜-Darboux property) with family of strong Świątkowski functions using the notions of strong c-algebrability. We also compare families of functions associated with density topologies.
On the Coefficients of Multiple Series with Respect to Vilenkin System
Authors: Skvortsov Valentin A. , Tulone Francesco
Published: November 2017

We give a sufficient condition for coefficients of double series Σ Σ
n,m

an,m
χ
n,m
with respect to Vilenkin system to be convergent to zero when n + m → ∞. This result can be applied to the problem of recovering coefficients of a Vilenkin series from its sum.
Application of Change of Direction Deficit to Evaluate Cutting Ability
Authors: Cuthbert Matthew , Thomas Christopher , Dos'Santos Thomas , Jones Paul A.
Published: November 2017

Cuthbert, M, Thomas, C, Dos'Santos, T, and Jones, PA. Application of change of direction deficit to evaluate cutting ability. J Strength Cond Res 33(8): 2138–2144, 2019—The purpose of this study was to examine the application of the change of direction deficit (CODD) to a 90° cut test to examine whether CODD provides a unique evaluation of an individual's cutting ability. Thirty-six male collegiate team–sport (23 Rugby/13 Soccer) athletes (age: 20 ± 1.4 years; height: 1.80 ± 0.08 m; mass: 83 ± 13.2 kg) participated in the study. Each athlete performed 3 trials of a 20-m sprint (with 5 and 10 m splits) and 2 change of direction (COD) tests (90° cut and 505 tests) cutting/turning from both legs. Completion times for all sprint and COD tests were measured using timing cells. For both COD tests, CODD was determined (COD completion time—10 m sprint time). Pearson correlation was used to explore the relationships between sprint times and CODD and completion times. Significant (p < 0.001) moderate-to-large (r ≥ 0.467) correlations between sprint times and 90° cut completion times for left and right cuts were observed. Nonsignificant (p > 0.05) trivial-to-small correlations (r ≤ 0.199) were found between sprint variables and 90° cut CODD. Significant (p < 0.001) large to very large correlations (r ≥ 0.531) were revealed between the left and right 90° cut and 90° cut CODD. The results suggest that the CODD could be applied to isolate and assess the cutting ability in COD speed tests that involve a single cutting maneuver. Failure to inspect CODD could lead to incorrect evaluation of an athletes cutting or COD ability.
Practical Fitness Profiling Using Field Test Data for Female Elite-Level Collegiate Soccer Players: A Case Analysis of a Division I Team
Authors: Lockie Robert G. , Risso Fabrice G. , Giuliano Dominic V. , Orjalo Ashley J. , Jalilvand Farzad
Published: November 2017

THIS ARTICLE WILL PROVIDE PRACTICAL EXAMPLES OF HOW FIELD TESTING DATA CAN BE PRESENTED TO HIGHLIGHT THE CHARACTERISTICS OF INDIVIDUAL SOCCER PLAYERS. AN EXAMPLE TESTING BATTERY WILL BE DESCRIBED, AS WILL THE PROCESS FOR CONVERTING TEST DATA INTO STANDARDIZED SCORES. DATA WILL BE PRESENTED TO SHOW THE STRENGTHS AND WEAKNESSES OF CERTAIN PLAYERS, AND HOW THIS INFORMATION CAN BE USED TO INFORM INDIVIDUALIZED TRAINING PROGRAMS. EXAMPLES OF DATA COMPARISONS TO NORMATIVE VALUES FOR ELITE PLAYERS WILL ALSO BE PRESENTED, IN CONJUNCTION WITH DISCUSSION AS TO HOW THIS INFORMATION CAN CONTRIBUTE TO THE PRACTICES OF THE STRENGTH AND CONDITIONING COACH.
Cross-Laboratory Analysis of Brain Cell Type Transcriptomes with Applications to Interpretation of Bulk Tissue Data
Authors: Mancarci B. Ogan , Toker Lilah , Tripathy Shreejoy J. , Li Brenna , Rocco Brad , Sibille Etienne , Pavlidis Paul
Published: November 2017

Establishing the molecular diversity of cell types is crucial for the study of the nervous system. We compiled a cross-laboratory database of mouse brain cell type-specific transcriptomes from 36 major cell types from across the mammalian brain using rigorously curated published data from pooled cell type microarray and single-cell RNA-sequencing (RNA-seq) studies. We used these data to identify cell type-specific marker genes, discovering a substantial number of novel markers, many of which we validated using computational and experimental approaches. We further demonstrate that summarized expression of marker gene sets (MGSs) in bulk tissue data can be used to estimate the relative cell type abundance across samples. To facilitate use of this expanding resource, we provide a user-friendly web interface atwww.neuroexpresso.org.
Orofacial Manifestation of Adverse Drug Reactions: A Review Study
Authors: Bakhtiari Sedigheh , Sehatpour Marziye , Mortazavi Hamed , Bakhshi Mahin
Published: November 2017

Background. Adverse reaction to medication is common and may have a variety of clinical manifestations in the oral cavity. The present review paper aimed to describe adverse drug reactions (ADRs) which might be encountered by dental practitioners in every discipline.Methods. In this narrative review article, the specialized databases such as PubMed, PubMed Central, MEDLINE, EBSCO, Science Direct, Scopus, and reference books from the years 2000-2016 were used to find relevant documents by using MeSH terms: Adverse Drug Reaction, Drug induced, Medication Related, Mouth, Oral Manifestation, Tooth, Hard Tissue, Soft Tissue.Results. The data were categorized in 4 groups as follows: saliva and salivary glands involvement, soft tissue (mucosal) involvement, hard tissue involvement, and non specific conditions (taste disorders, halitosis, neuropathies, movement disturbances, and infection). Most articles were about the adverse effect of drugs on the function of salivary glands, which often cause a decrease in saliva secretion. Other reactions were less common; meanwhile, the side effect of bisphosphonate was increasing in the alveolar bone, because of its unlimited prescription.Conclusion. Oral health care providers should be familiar with such events, as they will be confronted with them in their practice.
PSYCHOLOGICAL STRESS AND BREAST CANCER INCIDENCE: A SYSTEMATIC REVIEW
Authors: Chiriac Valentina-Fineta , Baban Adriana , Dumitrascu Dan L.
Published: November 2017

Objective. Breast cancer is the world's leading cause of cancer mortality in women. Stress is an imminent risk factor with a documented negative impact on neuro-endocrine and immune system.  Numerous epidemiological studies have investigated the link between stress and cancer, reporting contradictory results from no association to a close causal link. The impact of the topic and the lack of conclusion compelled this systematic review.Methods. A systematic review was carried out, including all literature studies from 1966 to 2016, investigating the relationship between stress and the occurrence of breast cancer. Of the 1813 articles identified in the PubMed/Medline database, 52 were eligible and included in the analysis.Results. A number of 17 retrospective, 20 limited prospective and 15 prospective studies were analyzed. The number of patients exceeded 29,000, for a total number of more than 700.000 women recruited from hospital, screening cohorts or population registers. We identified 26 positive articles linking personal traits, stressful events and breast cancer, 18 negative articles that did not confirm their hypothesis and 8 articles that could not be classified. Facing heterogeneity, all possible misguiding factors such as: study design, information gathering, stress type, moment of exposure, individual susceptibility and personality, were discussed independently.Conclusions. Qualitative analysis of articles has revealed a possible association between stress and cancer, especially regarding stressful life events. In the absence of a meta-analysis and taking into account the methodological heterogeneity of the studies, the results are difficult to interpret and the role of chance is difficult to exclude.
Evaluation of the HEDUQUAL Scale Intended for Assessment of Students’ Perceptions of Service Quality in Higher Education Institution in Vojvodina/Evaluacija HEDUQUAL skale namijenjene procjeni studentske percepcije kvaliteta usluga visokoškolskih ustanova
Authors: Nešić Milan , Ahmetović Zlatko , Srdić Velibor , Badrić Marko
Published: November 2017

AbstractThis research was carried out in order to evaluate metric characteristics of the HEDUQUAL scale, whose purpose is to assess quality of service in higher education institutions. The same scale can be used for further research among student population. The research sample consisted of 257 students (of both sexes) from three higher education institutions from Autonomous Province (AP) Vojvodina. Metrics of the HEDUQUAL scale was tested via three procedures: 1) evaluation of the scale’s internal consistency (Scale Reliability Analysis which is based on Cronbach’s alpha coefficient); 2) evaluation of validity based on internal correlation coefficient of the scale (Spearman’s rank correlation – rho); and 3) factor analysis (analysis of the main components – Principal Components Analysis) using the method of Direct Oblimin rotation. All statistical conclusions were made at the level of significance of 0.05 (Sig.  .05). The results indicate that the tested instrument is valid, reliable and that it should be used as a multi-item and one-factor scale in further research on student population. Key words: HEDUQUAL scale; multi-item one-factor scale; reliability; students; validity. ---SažetakIstraživanje je provedeno s ciljem provjere metrijskih karakteristika HEDUQUAL skale, koja je namijenjena procjeni kvaliteta usluga visokoškolskih ustanova. Ista skala posije bi se koristila za daljnja istraživanja među studentskom populacijom. Uzorak ispitanika činilo je ukupno 257 studenata (oba spola) s tri visokoškolske ustanove iz AP Vojvodina. Metrijske karakteristike HEDUQUAL skale testirane su primjenom tri postupka: (1) provjerom njezine unutarnje konzistencije (Scale Reliability Analysis koja je utemeljena na Cronbachovu alfa koeficijentu); (2) provjerom valjanosti utemeljenom na koeficijentu unutarnje korelacije skale (Spearmanov koeficijent korelacije – rho); i (3) faktorskom analizom (analiza glavnih komponenti – Principal Components Analysis) s metodom kose rotacije (Direct Oblimin). Sva statistička zaključivanja provedena su na razini  značajnosti od 0,05 (Sig.  ,05). Dobiveni rezultati pokazuju da je testirani instrument valjan i pouzdan te da se treba koristiti u daljnjim istraživanjima na studentskoj populaciji  kao jednofaktorska skala s više čestica.Ključne riječi: HEDUSQUAL skala; jednofaktorska skala višestrukih čestica; pouzdanost; studenti; valjanost.
Acid rain intrusion effects on the compressibility behaviour of residual soils
Authors: Bakhshipour Zeinab , Asadi Afshin , Sridharan Asuri , Huat Bujang B K
Published: November 2017

This paper presents the results of experiments designed to investigate the effect of acid rain on the compressibility behaviour of residual soils. Sedimentary residual soil (SRS) and igneous residual soil (IRS) with different mineral compositions were collected from two locations in Malaysia. The specimens were infiltrated by artificial acid rain (AAR) at varying pH values of 2, 3, 4, 5 and 5·6 and at different fluxes of 1, 5 and 20 years. At the end of each AAR flux interval, compressibility, zeta potential, atomic adsorption spectroscopy, X-ray diffraction and scanning electron microscope analyses were performed to study the behaviour of the soil in an acidic environment. It was found that AAR has a strong effect on soil structure; consequently, the compressibility of both SRS and IRS increased as the pH value decreased and/or as the flux of AAR increased. Microstructural analyses confirmed that this process destroyed the bonds between clay particles/aggregates and induced significant changes in mineral structure due to the dissolution of alumina and silica from SRS and IRS, resulting in the formation of ‘loose’ structures with larger voids.
Capillary barriers incorporating non-woven geotextiles
Authors: Lima Marlon J , Azevedo Marcelo M , Zornberg Jorge G , Palmeira Ennio M
Published: November 2017

Capillary barriers can be an effective solution to minimise or delay infiltration of liquids in soils. These alternative barriers may be particularly appropriate and cost-effective in cover systems of waste disposal systems in arid and semi-arid regions. The mechanism of flow control in a capillary barrier involves the impedance of flow moving from a porous medium of small voids to another porous medium of larger voids, due to differences in the water storage between the two materials for the same suction at their interface. Granular soils have been used to induce a capillary barrier. However, the use of geotextiles as barriers can offer not only the relevant difference in water storage but also the repeatability and consistency of properties offered by manufactured materials, besides other advantages. The objective of this paper is to investigate the behaviour of capillary barriers using non-woven geotextiles under controlled laboratory conditions. Accordingly, fine-grained soil and geotextiles with different properties were used in the testing programme. Granular materials (sand and gravel) were also utilised to form granular capillary barriers for comparison purposes. Overall, the experimental results show that geotextiles can develop capillary barriers with similar storage capability as those provided by natural granular materials.
Taxonomy of Global Risk, Uncertainty, and Volatility Measures
Authors: Datta Deepa , Londono Juan M. , Sun Bo , Beltran Daniel , Ferreira Thiago , Iacoviello Matteo , Jahan-Parvar Mohammad R. , Li Canlin , Rodriguez Marius , Rogers John
Published: November 2017

A large number of measures for monitoring risk and uncertainty surrounding macroeconomic and financial outcomes have been proposed in the literature, and these measures are frequently used by market participants, policy makers, and researchers in their analyses. However, risk and uncertainty measures differ across multiple dimensions, including the method of calculation, the underlying outcome (that is, the asset price or macroeconomic variable), and the horizon at which they are calculated. Therefore, in this paper, we review the literature on global risk, uncertainty, and volatility measures drawing on internal and external academic research as well as ongoing monitoring conducted by the Federal Reserve Board’s economics divisions to catalog measures by method of data collection, computation, and subject. We first explore a set of non asset-marketbased measures of risk and uncertainty, including news-based and survey-based uncertainty measures of monetary policy and macroeconomic outcomes. We then turn to asset-market-based measures of risk uncertainty for equity prices, interest rates, currencies, oil prices, and inflation.
Analysis of CYP2C9*2, CYP2C19*2, and CYP2D6*4 polymorphisms in patients with type 2 diabetes mellitus
Authors: Semiz Sabina , Dujic Tanja , Ostanek Barbara , Prnjavorac Besim , Bego Tamer , Malenica Maja , Marc Janja , Causevic Adlija
Published: November 2017

This is the first study performed in population from Bosnia & Herzegovina (BH), in which we analysed a significance of genetic variations in drug-metabolising enzyme, cytochrome P450 (CYP), in pathogenesis of Type 2 diabetes. We have determined allele frequencies for CYP2C9*2, CYP2C19*2, and CYP2D6*4 in diabetic patients and nondiabetic controls. Genomic DNA was extracted from blood samples collected from 37 diabetic and 44 nondiabetic subjects. A real-time polymerase chain reaction was used for the detection of specific CYP polymorphisms, with the application of the specific TaqMan’ SNP genotyping tests (AppliedBiosystems). Interestingly, results from this study have demonstrated that frequencies of CYP2C19*2 and CYP2D6*4 variants were in line, while frequency of CYP2C9*2 polymorphism seemed to be lower in this sample of BH population as compared to the Caucasians genotype data. Furthermore, no significant difference in allele frequencies for CYP2C9*2, CYP2C19*2, and CYP2D6*4 was demonstrated between diabetic and nondiabetic subjects. Thus, results form this study seem to indicate no relationship between CYP2C9, CYP2C19, and CYP2D6 genotype and diabetes susceptibility in Bosnian population. This in part may reflect a limited study population included in our study and would require larger cohorts to reveal potential relationships between analysed CYP genetic variants and diabetes risk. In addition, it would be pertinent to further explore possible effects of CYP genetic variations on therapeutic and adverse outcomes of oral antidiabetics, which might be the key in optimising therapy for individual patient with Type 2 diabetes.
Assays for studying Listeria-Containing Vacuoles v2
Authors: Bierne Hélène , Kortebi Mounia , Milohanic Eliane
Published: November 2017

Listeria monocytogenes is a bacterial pathogen that enters and proliferates in the cytosol of mammalian cells. Following entry, bacteria disrupt the invasion vacuole and reach the cytoplasm, where they replicate and use the actin cytoskeleton to propel themselves from cell to cell [1, 2]. To achieve this cytosolic lifestyle, Listeria deploys virulence effectors that hijack diverse cellular processes [3, 4]. Human epithelial cells grown in vitro can be used to study the L.monocytogenes infectious process. However, rapid multiplication and dissemination of bacteria may induce cell death and detachment, thereby forming lytic plaques. Thus, in vitro infections with L.monocytogenes have been restricted to short time courses (usually from a few minutes to one day). In order to study L.monocytogenes long-term infections, we have set up a protocol, with several modifications to the gentamicin protection assay previously used for short-term infections with this pathogen [5]. In a subset of human cells, such as hepatocytes or trophoblast cells, this protocol enables to observe and study the entrapment of L.monocytogenes within vacuoles, termed “Listeria-Containing Vacuoles” (LisCVs), after the intercellular dissemination phase of Listeria. Here, this protocol describes the assays used to study LisCVs in a JEG3 trophoblast cell monolayer.
Role of Mentoring System in Professional Development of Entry-Level Teachers
Authors: Arzhanykh E.V.
Published: November 2017

The system of mentoring permits to eliminate the "gap" between the theoretical knowledge received by novice teachers during their university studies and the required qualification characteristics (described in the Russian Professional Standard for Teachers).This article presents the research data on the role of the system of mentoring in the professional development of young general education teachers.The data was obtained through a survey of entry-level and experienced teachers (490 participants) conducted in 6 regions of the Russian Federation in May-June 2016.According to the survey, most of the young professionals admit that more experienced colleagues can teach them a lot, but more than half of novice teachers believe that they "are often not up to date with current trends in pedagogy", and individual mentor assistance is not considered by novice teachers as a preferred form of professional development.The results of the survey showed that at present the institute of mentoring in the professional development has more importance for experienced teachers than for their young colleagues.
Conceptual Framework of Crisis Negotiation Competency Development in Managers of Internal Affairs Bodies
Authors: Vakhnina V.V. , Maidykov A.F. , Ulyanina O.A.
Published: November 2017

In this article the authors examine the psychological features of the development of an integral psychological concept of crisis negotiation activities from the perspective of system-situational and reflexive approaches.This research forms the basis of a new scientific direction in legal psychology, the psychology of crisis negotiation activities of employees of internal affairs bodies, as a system of coping with and preventing crisis in negotiations.The data was collected and analysed in several stages from 1995 to 2014 and included a survey of managers of internal affairs bodies as well as a systematic analysis of the data pool of 1705 crisis situations.Basing on the analysis the authors propose a matrix of negotiations which identifies priority strategies and possible crisis zones at various stages of the negotiation process depending on the characteristics of the situation, thus helping to carry out crisis negotiations effectively.
Váro-centric Diabetes Management
Authors: Kalra Sanjay ,   Department of Endocrinology, Bharti Hospital, Karnal, India
Published: November 2017

While efficacy and safety are proven for all modern glucose-lowering drugs, their tolerability may vary. This is especially true in terms of weight gain. This communication proposes a váro-centric model of diabetes care. This approach helps choose appropriate glucose-lowering therapy, based upon weight (body mass index). The váro-centric model suggests a weight-centric approach to selection of drugs. While respecting the tenets of patient-centred care and good clinical sense, it serves as a clinical and teaching tool for rational prescription in diabetes.
MC4R Mutation in Early-onset Severe Childhood Obesity—Genotype–phenotype Correlation
Authors: Birla Shweta ,   Laboratory of Cytomolecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India, Khandelwal Deepak ,   Department of Diabetes and Endocrinology, Maharaja Agrasen Hospital, Punjabi Bagh, New Delhi, India, Sharma Arundhati ,   Laboratory of Cytomolecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India, Khadgawat Rajesh ,   Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India
Published: November 2017

Melanocortin-4 receptor (MC4R; OMIM#155541) encodes a 332-amino acids protein possessing typical G-protein-coupled receptors’ (GPCRs) structural design having three intact and functional domains, mutations which lead to the most recurrent type of monogenic obesity. Methods: We report here a case of a 5-year-old boy from Iraq who presented to the clinic for evaluation of progressive weight gain since he was 6 months of age. There were no symptoms of hypothalamic dysfunction except increase in appetite. His height was 120 cm (97th centile of the Centers for Disease Control and Prevention [CDC] growth chart, mid parental height was 50th centile), weight was 57 kg (>97th centile on CDC chart) and body mass index was 39.6 kg/m2 (>97th centile on CDC chart). A monogenic cause of obesity was strongly suspected in view of early onset severe childhood obesity. Results: Mutation screening of MC4R revealed a homozygous isoleucine by arginie at codon 69 (I69R) mutation in the patient, while his father was heterozygous for this mutation. Conclusion: We describe a monogenic form of obesity with characteristic presentation due to I69R MC4R mutation inherited as an autosomal recessive condition. The finding is different from previous reports which have documented this mutation to be inherited in a dominant manner. The findings of the present study reiterate the complex nature of obesity with possible involvement of modifier genes and/or genetic heterogeneity in its causation.
El sepulcro de Jean Bonaventure Thiéry du Mont, conde de Gages, obra del escultor académico Roberto Michel, a través de la mirada de eruditos y viajeros
Authors: Tarifa Castilla María Josefa
Published: November 2017

El presente artículo estudia el sepulcro de Jean Bonaventure Thiéry du Mont (1682-1753), conde de Gages, destacado militar belga y político al servicio del monarca español Felipe V, labrado por el escultor académico Roberto Michel (1767). La consulta de fuentes literarias y archivos locales y nacionales desvela la génesis del proyecto funerario con propuestas de distintos diseños, y la visión que tuvieron del mausoleo los eruditos y viajeros que lo contemplaron en los diferentes emplazamientos en los que estuvo, el originario en la iglesia de capuchinos de Pamplona y su posterior traslado a la catedral y claustro de dicha seo.
El palacio de los Páez de Castillejo. El ascenso social de un linaje
Authors: Jordano Barbudo María Ángeles
Published: November 2017

A través de la documentación conservada y del análisis de los espacios, elementos arquitectónicos y ornamentales, es posible seguir la transformación de unas primeras casas, en las que aún pervive la tradición doméstica andalusí, en un palacio renacentista, bajo la dirección de uno de los arquitectos más interesantes y activos de Andalucía en ese momento, Hernán Ruiz II, quien culminará la nueva apariencia de la mansión con una portada que sella en Córdoba una evolución tipológica y al mismo tiempo consagra al linaje de los Páez de Castillejo gracias a un programa iconográfico que pivota en torno a la exaltación de las virtudes del guerrero como paradigma del ideal humanista.
Desenvolvimento Regional: as Instituições de Ensino Superior (IES) e a Interação com o Distrito Agroindustrial de Anápolis (DAIA)
Authors: De Lima Karla Kellem , De Lima Tereza Cristina Medeiros Pinheiro , Pasqualetto Antônio
Published: November 2017

Resumo: no mundo globalizado as organizações são desafiadas à competitividade, necessitando ampliar o conhecimento em ambiente tecnológico propício à inovação. Objetivou-se conhecer; discutir e analisar a expansão das Instituições de Ensino Superior (IES) de Anápolis e a relação de cooperação e interação com o Distrito Agroindustrial de Anápolis (DAIA). Realizou-se pesquisa qualitativa, tendo como instrumento a aplicação de questionário ao responsável pelo setor de Recursos Humanos do DAIA e nas IES foram realizadas entrevistas com os diretores de unidades de ensino buscando identificar quais os serviços e ações, vantagens e desvantagens dessa interação. Os resultados demonstraram que para as organizações, as relações de cooperação são restritas à oferta de estágio e abertura do espaço para realização de visitas técnicas. Por outro lado, as IES visualizam que de forma positiva e sistematizada oferecem mão-de-obra regional capacitada às empresas do DAIA, que na maioria são oriundas de outros Estados contribuindo para o desenvolvimento regional.Palavras-chave: DAIA. Desenvolvimento Regional. Instituições de Ensino Superior.
Área de Ocupação da Cana-de-Açúcar no Estado de Goiás e o Efeito Substituição em Relação a outras Culturas de Abastecimento Alimentar (2003-2012)
Authors: Da Silva Leandro Ilidio , Leão Carlos , Pasqualetto Antônio
Published: November 2017

Resumo: este trabalho teve como o objetivo verificar o crescimento da área de ocupação da cana-de-açúcar no Estado de Goiás e o efeito substituição em relação a outras culturas de abastecimento alimentar entre o período de 2003 a 2012. Utilizou-se método de análise shif-share para explicar o Efeito Substituição (ES) ocorrido na composição das culturas em Goiás. Defende-se que as culturas com forte penetração, principalmente nos segmentos agroindustriais, apresentam maiores efeitos de substituição, em relação às demais. Os dados fora fornecidos pela Secretaria Estadual de Gestão e Planejamento (SEGPLAN), Companhia Nacional de Abastecimento (CONAB), Sindicato da Indústria de Fabricação de Álcool do Estado de Goiás (SIFAEG), União da Indústria de Cana-de-açúcar (?NICA) e Instituto Brasileiro de Geografia e Estatística (BGE). Os resultados demonstraram que a área de ocupação da agricultura goiana apresentou, no período, um efeito de substituição (ES) positivo forte, sobretudo nas culturas de cana-de-açúcar, milho e soja, apresentando o efeito substituição (ES) negativo nas culturas de arroz, sorgo e feijão.Palavras-chave: Agricultura goiana. Cana-de-açúcar. Modelo shift-share. Efeito Substituição.
Patentes en alimentación del prematuro inscritas en Estados Unidos entre 2013 y 2015
Authors: Martínez G. Ruby Ester , Boscán R. Neida Coromoto
Published: November 2017

Objetivo: revisar las patentes inscritas en la Oficina de Patentes y Marcas Registradas de Estados Unidos (United States Patent and Trade Mark Office) relacionadas con la alimentación de recién nacidos prematuros.
Metodología: se realizó una búsqueda transversal y bibliométrica de carácter documental y descriptivo; la población estuvo conformada por 15 patentes publicadas entre 2013 y 2015. Para la recolección de datos se utilizó una matriz. El procesamiento de la información se realizó con el software SPSS versión 10.
Resultados: la mayor actividad de inscripciones de patentes se concentró en el año 2015; los productos de mayor desarrollo fueron los relacionados con fórmulas nutricionales enriquecidas, principalmente con grasas y proteínas. Las empresas asociadas fueron Abbott Laboratories, Prolacta Bioscience Inc. y Nutricia.
Niveles de radiación ultravioleta, fenotipos e infraestructura de protección solar en instituciones educativas de Piura, Perú
Authors: Dedios M. Ninell J.
Published: November 2017

Objetivo: analizar el comportamiento del nivel de radiación ultravioleta incidente en Piura y cómo influye en las personas en edad escolar según su fototipo.
Metodología: el registro de datos ultravioleta se basó en la información procedente del sensor meteorológico IUV Biometer modelo 501-A (Solar Light), SN 10734 (respuesta espectral 250/380 nm) durante el periodo 20082011. Se seleccionaron al azar 25 instituciones educativas donde se evaluó la existencia de algún tipo de techado sobre las áreas recreativas y se determinó el fototipo de los estudiantes.
Resultados: en Piura los niveles de radiación ultravioleta UVB están en el rango de 8 a 15 UVB, que corresponde a niveles de riesgo Moderado a Extremo y presentan dependencia con la estacionalidad. Las horas de mayor impacto sobre la piel ocurren entre 11:00 a.m. a 14:30 p.m., siendo las 12:00 la hora en que la población debe tener un mayor cuidado por la sobreexposición solar. El fototipo III (piel morena clara) se identificó como el más frecuente y sensible comparado con los fototipos IV (piel morena oscura) y V (piel oscura). El 31,91 % de los alumnos (6.046) realizan  sus actividades diarias de deporte o recreativas en áreas cubiertas y el 9,03  % (1.711) con techado parcial, mientras que el 59,07  % (11.193) se exponen diariamente a la radiación solar debido a que en su institución educativa no tiene un mecanismo externo de protección solar.
Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials
Authors: Savitskaya I. , Kistaubayeva A. , Digel I. , Shokatayeva D.
Published: November 2017

New bacterial cellulose/chitosan (BC/Ch) nanocomposite films were obtained using a simple procedure by immersing BC synthesized by Komagataeibacter xylinus in 1% acetic acid solutions of Ch with the degree of deacetylation 75‒85% of medium molecular weight. The BC and BC/Ch composites chemical composition was examined by FTIR, the mechanical properties by a tensile tester, surface morphology by scanning electron microscopy, and antibacterial activity against S. aureus, E. coli and P. aeruginosa by diffusion and joint incubation methods. The FTIR spectra indicated the intermolecular interaction between BC and Ch. Due to addition of 0.6% (w/v) Ch, the films of BC/Ch become more homogeneous with a significantly denser fibril structure, smaller pore diameter and higher surface area in comparison to those of pure BC films. Micro- (15‒35 nm) and macrofibrils (50‒150 nm) in both BC and BC/Ch films are joined in ribbon-like fibers, providing a high degree of mechanical strength (Young’s modulus: 33‒36 MPa, tensile strength and elongation et break: 17, 22 MPa). The obtained hybrid material is transparent, flexible and displays good water absorption capacity and water vapor permeability. The films have reasonable thermal stability to be in contact with body or during steam sterilization, since maximum degradation temperature (Td) of both biocomposites is around 400‒600 °C. The disc diffusion method confirmed that the BC/Ch films have predominantly non-diffusible antibacterial properties. Antibacterial assessment by the joint incubation method proved that addition of Ch to BC films resulted in significant growth inhibition against target bacteria. The BC/Ch biocomposites’ notable properties make them suitable for wound healing applications.
Cu-Expanded Graphite Composite Material Preparation and Thermal Properties
Authors: Karzov I. , Shornikova O. , Filimonov S. , Malakho A. , Avdeev V.
Published: November 2017

A composite material based on expanded graphite (EG) and copper compounds was obtained by natural graphite oxidation with 95% nitric acid, copper (II) nitrate and granular carbamide addition with further rapid heat treatment at three different exfoliation temperatures: 800, 1000 and 1200 °С. It was found that the composition of copper containing graphite material depends on the temperature and the atmosphere of thermal expansion. The formation of copper oxides can be eliminated if rapid heat treatment is conducted in nitrogen at 1200 °С. Thermal conductive properties: thermal diffusivity and specific heat capacity of obtained Cu-expanded graphite samples were measured. It was revealed that the dependence of thermal conductivity (TC) of Cu-graphite material has non-linear character in the studied range of copper content. The incorporation of 3% copper into expanded graphite allows to increase its thermal conductivity by 20% while the further Cu content growth leads to the TC decrease from 6 to 4.5
W/(m∙K). The specific heat capacity is constant at ω(Cu)<3% and reduces in the range (3‒8)% Cu. The advantage of proposed technique of Cu-expanded graphite materials preparation is exclusion graphite intercalation compounds hydrolysis step with further drying because of carbamide addition.