bluuebunny/crossref_metadata_2025 huggingface dataset:
Terapi Swedish Massage menurunkan Tingkat Kecemasan Lansia di Balai Pelayanan Sosial Tresna Wredha (BPSTW) Unit Budi Luhur Yogyakarta
Authors: Sukmawati Anastasia Suci , Pebriani Ega , Setiawan Arif Adi
Published: September 2018

Berbagai macam perubahan akan dialami oleh lansia seperti perubahan fisik, psikologi, maupun psikososial akan menimbulkan masalah baru pada lansia salah satunya adalah kecemasan. Tehnik alternatif yang dapat digunakan untuk menurunkan kecemasan seseorang yaitu seperti yoga, meditasi, aromaterapi, dan relaksasi melalui pijat (massage). Penelitian ini dilakukan untuk mengetahui pengaruh Swedish mas- sage terhadap tingkat kecemasan lansia. Metodologi: Desain penelitian ini adalah quasy experiment dengan one group pretest-post test design. Responden pada penelitian ini adalah lansia yang mengalami kecemasan dengan menggunakan teknik total sampling yaitu sebanyak 15 lansia di Balai Pelayanan Sosial tresna Wredha (BPSTW) Unit Budi Luhur Bantul Yogyakarta. Instrumen penelitian adalah instrument HARS. Responden diukur tingkat kecemasannya sebelum dan setelah dilakukan Swedish massage selama 1 minggu. Hasil penelitian dianalisis dengan uji Wilcoxon. Hasil : Tingkat kecemasan pada lansia di BPSTW Budi Luhur Bantul Yogyakarta sebelum diberikan Swedish massage kategori sedang sebanyak 8 orang (53,3%). Tingkat kecemasan sesudah diberikan Swedish massage kategori ringan sebanyak 8 orang (53,3%). Perubahan tingkat kecemasan sebelum dan sesudah diberikan Swedish massage menunjukkan perbedaan sebesar 2,00. Hasil uji Wilcoxon diperoleh dengan nilai p-value 0,008 < 0,05. Diskusi : Swedish massage berpengaruh terhadap tingkat kecemasan pada lansia di BPSTW Budi Luhur Bantul Yogyakarta.
Hubungan Perilaku Kekerasan Pasien dengan Stres Perawat di Instalasi IPCU RSJ. Dr. Radjiman Wediodiningrat Lawang
Authors: Muhith Abdul , Fardiansyah Arief , Mawaddah Nurul , Mulyatin Mulyatin
Published: September 2018

Perawat psikiatri intensive care unit berada dalam lingkungan yang terbatas yang memungkinkan perawat dekat dengan pasien untuk dapat mengobservasi kondisi klien dan mengevaluasi tindakan perawatan maupun tindakan medis yang dilakukan. Jika perawat tidak siap dengan kondisi tersebut akan dapat menimbulkan ketegangan pada perawat yang berakibat stres. Salah satu tugas perawat jiwa adalah penanganan perilaku kekerasan (agresif), persepsi yang buruk perawat menjadikan stres kerja (Muhith, 2015). Penelitian ini bertujuan menganalisis hubungan antara Perilaku Kekerasan Pasien dengan Stres pada perawat di Intensive Psychiatry Care Unit (IPCU) RS Dr.Radjiman Wediodiningrat Lawang. Desain penelitian cross sectional. Populasi sejumlah 40 orang dengan sampel sebanyak 28 orang. Teknik pengambilan sampel simple random sampling. Variabel bebasnya adalah Perilaku Kekerasan Pasien, sedangkan variabel tergantungnya adalah Stres. Alat ukur menggunakan kuesoner. Waktu penelitian......Analisis data menggunakan uji korelasi Spearman. hasil uji Korelasi Spearman didapatkan hasil r = 0,738 p = 0,000 (p < 0,05), maka dapat diperoleh hasil bahwa ada hubungan yang bermakna antara Perilaku Kekerasan Pasien dengan Stres pada perawat di Intensive Psychiatry Care Unit (IPCU) RS Dr.Radjiman Wediodiningrat Lawang. Berdasarkan hasil penelitian bahwa Perilaku kekerasan pasien di Intensive Psychiatry Care Unit (IPCU) RS Dr.Radjiman Wediodiningrat Lawang sebagian besar dalam kategori tinggi, sedangkan sebagian besar Perawat mengalami stress yang sedang. Dengan demikian diharapkan pihak rumah sakit dapat menciptakan suasana yang nyaman dan aman baik bagi pasien maupun perawat yang bekerja, sehingga kejadian stres bisa diminimalkan dan dikelola dengan baik.
Expresiones analíticas de la erosión de suelo e impacto en su productividad
Authors: Sánchez Cohen Ignacio , Pedroza Sandoval Aurelio , Velásquez Valle Miguel A. , Bueno Hurtado Palmira , Esquivel Arriaga Gerardo
Published: September 2018

Las aproximaciones para la estimación y proyección de pérdida de suelo en cuencas hidrológicas, varían desde las ecuaciones empíricas, hasta el uso de modelos basados en la física ambiental. El presente estudio tuvo como objetivo generar y proponer el uso de una ecuación diferencial logística para la estimación de pérdida de suelo. Mediante el uso de un modelo exponencial bajo condiciones de deterioro del suelo, se estimó la pérdida de rendimiento del cultivo maíz en 3.5 t ha-1 al pasar de 4.5 a 1 t ha-1. El modelo de erosión se parametrizó con información de una cuenca experimental del INIFAP situada en el municipio de San Luis del Cordero, Durango. Los resultados indican que la tasa promedio anual de pérdida de suelo es de 0.44 mm año-1, para lo cual se consideró como tasa crítica de pérdida de suelo 10 mm año-1. Con esa tasa inicial, el agostadero alcanzaría su tasa máxima permisible en 19 años. Este estudio analiza el comportamiento de los parámetros del modelo de donde se ensayaron otros escenarios de pérdida de suelo donde la tasa máxima permisible se alcanza en diferentes tiempos.
Cultivo in vitro de pétalos de cuatro variedades de Begonia elatior
Authors: Velasco Martínez Fernanda , González Rosas Héctor , Castillo González Ana María , Gaytán Acuña Elda Aracely
Published: September 2018

Esta investigación se llevó a cabo con el objetivo de establecer el protocolo para conocer la totipotencia del pétalo para la generación de plántula masivamente mediante la adición, al medio de cultivo, de una auxina y una citocinina e inducir la clonación de cuatro variedades de Begonia elatior. Se emplearon pétalos completos que fueron cultivados en medio de cultivo Murashige y Skoog en un diseño experimental completamente al azar consistente en cinco niveles combinados de ANA y BA (0, 1, 0.5, 2 y 3 mg L-1). La mayor regeneración de callo registró, en promedio, de 57.2%, en pétalos de la cv ‘Heidi’ y de 46.4% en la variedad ‘Gloriosa’. Estos resultados se dieron a los 65 días de cultivo medio MS suplementado con 1 mg L-1 de ANA y 1 mg L-1 de BA. La mejor formación de brotes y crecimiento se obtuvo el medio MS adicionado con 1 mg L-1 de ANA y 1 mg L-1 de BA con 13.2% en la variedad ‘Heidi’ y ‘Gloriosa’. Ocasionalmente se presentaron yemas florales en el tratamiento 1 mg L-1 de ANA+ 1 mg L-1 de BA en la cv ‘Heidi’. La formación de raíz se obtuvo, únicamente, en la variedad ‘Heidi’ y se indujo en el tratamiento 1 mg L-1 de ANA+ 1 mg L-1 de BA. Es posible obtener plántulas a partir de pétalos de Begonia elatior.
Producción de híbridos de maíz con urea estabilizada y nutrición foliar
Authors: Zamudio González Benjamin , Félix Reyes Amelia , Martinez Gutierrez Aaron , Cardoso Galvão João Carlos , Espinosa Calderon Alejandro , Tadeo Robledo Margarita
Published: September 2018

Se evaluaron seis híbridos de maíz en Ixtlahuaca, Villa Victoria y Temascalcingo, Estado de México, en arreglo de factorial, con urea convencional, Urea NitroXtend con Agrotain y Urea NitroXtend con Agrotain + S a razón de 250 kg ha-1 de N y cuatro tratamientos de fertilización foliar (Testigo, Quimcasa, Disagro y Bios). La combinación de los factores 3*6*3*4 con 4 repeticiones. Los tratamientos foliares se aplicaron en etapa V4-6 y V9-10. Se utilizó un diseño de parcelas sub-subdivididas; con la parcela mayor para híbridos, parcela media para tipos de urea, y parcela menor para tratamientos de fertilización foliar. Se empleó la prueba de Tukey al 5% para la comparación de medias. Para rendimiento de grano, las medias fueron Ixtlahuaca 13.6, Temascalcingo con 11.7 y Villa Victoria 10.8 t ha-1; por híbridos fue para el BG1304 de 14.24, BG1384  con 13.79, Syn1806 con 12.28, Albatros con 11.60, H-51AE con 10.25  y H-57AE con 10.24 t ha-1; no se encontró respuesta  a los tipos de  urea, en tanto que para fertilización foliar el testigo (11.13 t ha-1) fue superado por el tratamientos Quimcasa (12.36 t ha-1), Disagro (12.49 t ha-1) y Bios (12.30 t ha-1). Se encontraron interacciones positivas de híbridos (H) por tipos de ureas (U) y de híbridos x fertilización foliar (F). Los altos rendimientos obtenidos se debe a la utilización de nuevos híbridos y la adopción de las mejores prácticas agrícolas (MPA,s) entre las cuales se destaca la fertilización al suelo y la nutrición foliar.
FREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY
Authors: Andrievskaya I. A. , Ishutina N. A. , Kutepova O. L.
Published: September 2018

The aim of the study was to assess free radical processes and their effect on oxygenation of hemoglobin in the blood of 18-21 weeks  pregnant women with exacerbation of cytomegalovirus infection. We  examined 40 pregnant women with exacerbation of cytomegalovirus  infection and various levels of specific antibodies (IgM) at 18-21  weeks and 30 pregnant women without cytomegalovirus. The  spectrophotometric method was used to determine the content of oxyhemoglobin, methemoglobin, thiobarbituric acid (TBA)-active  products, superoxide dismutase in blood erythrocytes; thin layer  chromatography – phosphotidylcholine, lysophosphatidylcholine;  gas-liquid chromatography – arachidonic acid. Exacerbation of  cytomegalovirus infection changes the activity of free radical  oxidation processes, the severity of which is determined by the level  of IgM antibodies and is manifested by a decrease in superoxide  dismutase (p = 0.000) and phosphatidylcholine (p = 0.000), an  increase in phospholipase A2 (p = 0.000), lysophosphatidylcholine (p  = 0.000), arachidonic acid (p = 0.000) and TBA-active products  (p = 0.000). Accumulation of superoxide anion radical and products of lipoperoxidation in erythrocytes decreases  oxyhemoglobin (p = 0.000) and increases methemoglobin (p =  0.000). Exacerbation of cytomegalovirus infection at 18-21 weeks is  associated with the enhancement of free radical lipid oxidation and a  deficiency in the antioxidant activity of superoxide dismutase. It  decreases oxygen transport properties and increases phagocytosis  by red blood monocytes; and pregnant women develop further  hemic hypoxia.
LECTINS IN ANTI-CANCER STRATEGIES
Authors: Lakhtin M. V. , Lakhtin V. M. , Aleshkin V. A. , Afanasiev M. S. , Afanasiev S. S.
Published: September 2018

The published during last few years data concerning communicative role of lectins (proteins and their complexes which recognize  carbohydrates, glycoconjugates and their patterns) in on-duty  supporting and increasing anticancer status of human immunity are  analyzed. Examples of lectin-(glycoconjugate pattern) strategies,  approaches and tactic variants in study and development of  anticancer treatments, principle variants of therapy, possible  vaccines in 35 cases of blood connected tumors (leukemia,  lymphomas, others), solid tumors (carcinomas, sarcoma, cancers of vaginal biotopes, prostate, bladder, colon, other intestinal  compartments, pancreas, liver, kidneys, others) and cancer cell lines  are described and systemized. The list of mostly used communicative lectins (pattern recognition receptors, their soluble forms, other  soluble lectins possessing specificities of importance) involving in key intercellular cascades and pathway co-functioning is presented. The  regulation of resulting expression of distinct active lectins (available and hetero/di/oligomeric forms) and their interaction to  adequate glycoconjugate patterns as well as influence distribution of  co-functioning lectins and antigens CD between populations and  subpopulations of antigen-presented cells (dendritic cells cDC, mDC,  moDC, pDC; macrophages M2 and M1), mucosal M-cells, NK-cells  play key role for choice and development of anticancer complex  procedures increasing innate and innate-coupled immune responses.  Prospects of (receptor lectin)-dependent intercellular  communications and targeting glycoconjugate constructions into  innate immunity cells for therapy of cancer and development of anticancer vaccines are evaluated and discussed.
BORON PREPARATIONS IN PSYCHIATRY AND NEUROLOGY: THEIR RISE, FALL AND RENEWED INTEREST
Authors: Bekker R. A. , Bykov Yu. V.
Published: September 2018

The use of boron preparations (borax and boric acid) in medicine began long before their isolation in pure form. The mineral water of  boron-containing sources has been historically used to treat skin  diseases, to wash eyes, to disinfect wounds, etc. Also, what is of  interest in the context of this article, boron-containing waters were  used as calming, anti- anxiety, anticonvulsant and sleep-promoting  remedy. In 1777, boric acid was first isolated from the mineral water of a healing spring source in Florence. Historically, first name  of this compound was sal sedativum (“soothing salt”). However, the  discovery of boron toxicity led to the cessation of its internal use. In  recent decades, it has been found that boron is a microelement  necessary for many metabolic processes in the body. It affects  memory, cognitive functions, anxiety level, sleep, mood, regulates  calcium and magnesium exchange, metabolism of vitamin D and sex  steroids. It has been shown that some cases of treatment  resistance to standard therapy, for example in epilepsy, anxiety and depression, are related to boron deficiency. In this regard,  interest in the use of boron preparations in psychiatry and neurology, but in much smaller doses and on new scientific grounds, flared up again.
ASSESSMENT OF INDICES OF NONSPECIFIC RESISTANCE OF THE ORGANISM IN CONDITIONS OF NARROWING OF THE LUMEN OF THE TRACHEA IN AN EXPERIMENT
Authors: Kurganskiy I. S. , Lepekhova S. A. , Zaritskaya L. V. , Batunova E. V. , Makhutov V. N. , Inozemtsev E. O. , Apartsin K. A. , Grigoryev E. G.
Published: September 2018

The narrowing of the lumen of the trachea due to cicatricial stenoses of the trachea is one of the urgent problems of the modern surgery.  The processes taking place in the trachea and lungs lead to a change in the state of the immune system. Assessment of the dynamics of  indices of nonspecific resistance is one of the methods for assessing  the severity of the course of the disease. We studied the indices of  nonspecific resistance of the organism in narrowing the lumen of the  trachea in an experiment in the early postoperative period.  The study was carried out on the basis of the scientific department  of experimental surgery with the vivarium of Irkutsk Scientific  Centre of Surgery and Traumatology, on 24 white male Wistar rats  with a body weight of 300–350 g. We simulated narrowing the lumen of the trachea by placing a silicone tube in the lumen of the trachea  for 14 days. The parameters of phagocytosis, the state of phagocytic activity of blood neutrophils, spontaneous NBT-test, induced NBT- test were studied. The animals were withdrawn from the experiment  on the 3rd, 7th and 14th day. We revealed that as a result of  narrowing of the lumen of the trachea with the original procedure,  the nonspecific resistance of the organism was violated with  inhibition of the phagocytic activity of leukocytes. There was  inhibition of phagocytic activity of leukocytes and depletion of the  functional reserve of leukocytes.
ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY
Authors: Muruev B. A. , Mondodoev A. G. , Matkhanov I. E. , Toropova A. A. , Shantanova L. N. , Dimitrov O. G. , Yundunova O. V. , Butukhanova I. S.
Published: September 2018

Background. Intensive physical exertion is one of the stress-factors leading to the decrease of non-specific resistance of the body,  significant increase in oxygen consumption followed by activation of  the lipid peroxidation and decrease of endogenic antioxidant system efficacy.

The aim of the present study was to evaluate the influence of the complex plant remedy on exercise tolerance of laboratory animals and to reveal mechanisms increasing physical endurance.

Materials and methods. The experiments were carried out on white Wistar rats weighing 190-220 g. The physical endurance of the animals was estimated by recording time of weighted swimming to  complete exhaustion in the pool. The weighting was 7 % of the body  mass. The water solution of the dry extract derived from five  medicinal plants was introduced intragastrically to the animals of the experimental group at the dose of 100 mg/kg in the volume of 10  ml/kg for 7 days (once a day), an hour before testing. The content of ATP, lactic acid and pyruvic acid were determined in the skeletal  muscle homogenate; glycogen was determined in the liver  homogenate; in the blood serum there was estimated concentration  of malonic dialdehyde, the activity of catalase; the concentration of  reduced glutathione was determined in the whole blood and the  activity of superoxide dismutase was estimated in erythrocytes.

Conclusion. The course introduction of the complex plant remedy to rats results in resilience to intensive physical exertion due to  optimization of energy metabolism, inhibition of free-radical  biomacromolecule oxidation processes and increase in endogenic antioxidant system activity.
GENETIC DRIFT AND GENE FLOW IN POPULATIONS OF THE GREAT GERBILS
Authors: Sutyagin V. V.
Published: September 2018

The article describes the additional evolutionary factors, apart from natural selection, which can influence the genetic structure of the  populations of the main carriers of the plague microbe – the great  gerbil. The influence of genetic drift on random fluctuation of alleles  is considered. With the help of a stochastic matrix, on the example  of the family group of gerbils consisting of four individuals, the  probabilities of the transition of allele frequencies from parents to  offspring are calculated. Based on the previously calculated size of  the neighborhood in gerbils, it is concluded that any large population  of great gerbils can be considered as small in terms of deviation of gene frequencies. In such small groups – parcels –  the drift of genes will be of great importance. In addition, the effect  of the gene flow on the genetic structure of the gerbil population on  the example of the simplest population model “continent-island” is  considered. The dynamics of changes in allelic frequencies for 100  generations has been calculated. It is shown that the allele  frequency during the 20-30 generations changes at the maximum  rate, and then slows as the equilibrium is approached. It is  concluded that different populations of gerbils should be considered  as separate historically formed structures, with different sequence of influence of external environmental factors on them.
THE DYNAMICS OF ORTHOHANTAVIRUS HANTAAN STRAINS REPLICATION ON THE MODEL OF MOUSE PERITONEAL MACROPHAGES
Authors: Pott A. B. , Iunikhina O. V. , Lyapun I. N. , Kompanets G. G.
Published: September 2018

Orthohantaviruses (Orthohantavirus genus, Hantaviridae family) are the causative agents of a widespread natural focal infection in the  Russian Federation, hemorrhagic fever with renal syndrome (HFRS).  An important role in the persistence of orthohantavirus in reservoir  hosts among other immunological responses, as well as in the  spread of the virus in the infected organism, is played by infected  macrophages, which, along with the vascular endothelium, are the main targets for orthohantaviruses.

The aim of our study was to investigate the characteristics of replication of orthohantavirus Hantaan strains isolated from  Apodemus mice and detect the influence of different values of  multiplicity of infection (MOI) on replication dynamics of orthohantaviruses on cell culture.

Materials and methods. We used 4 strains of Hantaan virus, isolated from A. agrarius (n = 2) and A. peninsulae (n = 2), captured in the different areas of Primorsky Krai of Russia. The  modeling of infection was performed on the primary cell culture of  mouse peritoneal macrophages with different MOI (from 10 to 0.1).  The assessing of infection was conducted via indirect fluorescent  antibody assay, and results were expressed as rate of antigen- positive cells per all cells in the field of vision. 

Results. Common dynamics of orthohantavirus infection on this in vitro model was characterized by periodically increased rates of  infected cells after 2, 4, 6 и 8 hours post infection (p.i.). Replication  of A. agrarius-borne strains was more intensive compare with  viruses, isolated from A. peninsulae, in the time point 4 hour p.i. on  the background the same MOI the statistically significant difference  of rate of antigen-positive cell 24.9 ± 2.38 % vs 15.2 ± 1.87 % (t =  3.20; p = 0.001414) was observed. Additionally, the decrease of MOI was followed by determined decrease of replication effectivity.

Conclusion. The results of our study showed the significant phenotyping heterogeneity of orthohantavirus Hantaan strains,  isolated from Apodemus mice, resulting in different rates of  replication in the culture of mouse peritoneal macrophages.
Penerapan Jaringan Saraf Tiruan Dalam Memprediksi Indikator Utama Ekonomi Dunia
Authors: Damanik Alan Boy Sandy , Bimantoro Agung
Published: September 2018

Economics is one of the most important aspects in the world. Economics greatly determines the progress and development of a country. However, there are still many countries with low economic levels. Therefore the aim of this study is to predict and determine the level of the main indicators of the world economy as one of the anticipatory steps to further increase the level of the country's economy. World Economic Indicator Data to be used is sourced from Bloomberg and Bank Indonesia. To find out further developments, it is necessary to research the existing data. The algorithm used is Backpropagatian Neural Network. Data analysis was carried out using artificial neural network method using Matlab R2011b software. The study uses 5 architectural models. The best network architecture produced is 3-43-1 with an accuracy rate of 86% and the Mean Squared Error (MSE) value is 1.336593.
Grafik Penentuan Komposisi Campuran Agregat Material Pengaspalan Jalan Memanfaatkan Metode Digital Differential Analyzer (DDA)
Authors: Anisya Anisya
Published: September 2018

The more advanced technology can make it easier for someone to do their work. Included in it in terms of making graphics that can be done using computer assistance. Where computers can represent human work functions. This study aims to create an application graph for the determination of the composition of the aggregate mixture and provide the results of the calculation of the percentage of each aggregate and provide recommendations whether the composition of the aggregate mixture is feasible or not to be used. The results of this study are a graphical application for determining the value of the composition of the aggregate mixture. This application has been tested using DOSBox and TURBO C ++. Based on the results of these trials it can be concluded that the application of graphs to determine the value of aggregate mixture composition can be used as a tool for making graphs of aggregate mixtures and determining the value of aggregate composition and providing recommendations in the form of recommendations.
Dikkat Eksikliği ve Hiperaktivite Bozukluğu Olan Çocuklarda Grup Aktivitesinin Benlik Algısı Üzerine Etkisi
Authors: BAFRALI Cemre , ALTUNTAŞ Onur
Published: September 2018

Amaç: Dikkat eksikliği
ve hiperaktivite bozukluğu tanılı çocuklarda grup aktivitesinin benlik algısı
üzerine etkisini incelemek idi. Gereç ve
Yöntem: Çalışmamıza ilköğretim 3. ve 4. sınıfta okuyan Dikkat Eksikliği ve
Hİperaktivite Bozukluğu tanısı olan ve ilaç kullanan 6 birey dâhil edildi.
Benlik algısı Piers-Harris Öz Kavram Ölçeği ile değerlendirildi. Grup
aktivitelerinin çocukların ilgi alanlarına göre oluşturulması için çocuklar ve
aileleri ile bireysel görüşme yapıldı. 6 hafta boyunca 6 çocuk ile haftada 1
saat grup aktivitesi yapıldı. Piers- Harris Öz Kavram Ölçeği müdahale
sonrasında tekrar uygulandı. Sonuçlar istatiksel olarak karşılaştırıldı. Sonuçlar: Çalışmamıza katılan 6 birey de
erkekti. Yaş ortalamaları 9,33 ± 0,51 idi. İlk ve son değerlendirmelerde
Piers-Harris Öz Kavram Ölçeğinin mutluluk, kaygı, popülarite, davranış ve uyma,
fiziksel görünüm, zihinsel ve okul durumu alanlarında istatistiksel olarak
anlamlı bir farklılık bulunmamıştır (p>0,05). Tartışma: Bu çalışmamızda ilk ve son değerlendirme sonuçlarında
benlik algısında önemli gelişmeler olmasına rağmen bu fark sonuçlara
yansımamıştır. Dikkat Eksikliği ve Hiperaktivite Bozukluğu olan çocuklara
uygulanan grup aktivitelerinin ailelere verilen benlik algısı eğitimleri ile
desteklendiği uzun dönem takipler ile incelenen çalışmalara ihtiyaç olduğunu
düşünmekteyiz.
REYE-LIKE SYNDROME IN THREE-YEAR-OLD CHILD
Authors: Postnikov S. S. , Mikhailova S. V. , Bryusov G. P. , Kostyleva M. N. , Gratsianskaya A. N. , Ermilin A. E.
Published: September 2018

The article reviews the literature on classical and atypical Reye’s syndrome, explores the circumstances that contribute to its  occurrence, provides criteria for diagnosing with an illustration in the form of an authentic case of Reye-like disease in a child of 3 years  old. Reye’s syndrome is a disease manifested by acute  encephalopathy in combination with fatty degeneration of the  internal organs, mainly the liver. This condition was first described in  1963 by an Australian pathologist who identified 21 cases of the  disease in children with influenza A who were taking acetylsalicylic  acid, 17 children died. In the future, the circle of infections that  preceded the development of Reye’s syndrome-acute respiratory  infections, chickenpox, entero- and rotavirus infections, in rare  cases, hepatitis A and HIV, bacterial infections: mycoplasma,  chlamydia, whooping cough, shigella, salmonella. Drugs that can cause the development of this syndrome: tetracycline,  zidovudine, diclofenac sodium, mefenamic acid, paracetamol,  amiodarone, warfarin, phenothiazine derivatives, histaminolytics  (dimedrol), valproic acid. Along with drugs, insecticides, herbicides,  hepatotoxic fungi can be used as triggers of the syndrome. There is  an age dependence of the development of this syndrome. The  pathogenesis of classic Reye’s syndrome is associated with  generalized damage to the mitochondria primarily in the brain, as well as in the liver, kidneys, muscles, myocardium and pancreas,  with the disturbance of oxidation of fatty acids in them and the  formation of fat degeneration of varying degrees. In addition to the  classic Reye’s syndrome, atypical Reye’s syndrome or Reye-like  disease is isolated, occurs in children under 5 with congenital  disturbance of oxidation of fatty acids. We observed in our clinic the  case of Reye-like disease in a girl of three years with infection and  taking antipyretics. In the discussion section, the features of the  given case are noted, the question of the appropriateness (in view of the generality of the clinic and the mechanisms of development) of  dividing the syndrome into classical and atypical is discussed. A new  name for both conditions is proposed — Reye’s disease in honor of  the discoverer, highlighting its two forms with an early and late  onset. Given the morphological changes in this syndrome —  steatosis of internal organs — authors seem to be appropriate  measures aimed at treating secondary mitochondrial insufficiency  and fatty dystrophy.
MYOPATHY CAUSED BY THE INTERACTION OF COLCHICINE AND STATINS
Authors: Kazakov A. S. , Darmostukova M. A. , Bukatina T. M. , Snegireva I. I. , Lepakhin V. K. , Zatolochina K. E.
Published: September 2018

Myopathy is a life-threatening disease that can be caused, among other things, by the intake of various medications. Despite the fact  that many drug-induced myopathies are well known, however, many  health professionals are not alert to myopathies caused by drug  interactions. Myopathy is a wellknown adverse reaction of statins,  and muscle damage can range from minor muscle pain and  weakness to life-threatening rhabdomyolysis. Colchicine can also  cause myopathy, including rhabdomyolysis. The combination of  colchicine and statins can significantly increase the risk of myopathy  compared with their intake separately. In cases of development of  myopathy in patients receiving colchicine and statins simultaneously, the most common manifestation of drug interaction was muscle  weakness, occurring in almost every case, and in some cases,  muscle weakness was so severe that the patient lost the ability to  move. In a third of cases, the development of muscle weakness was  accompanied by muscular pain, and darkening of urine to tea shade.  One study showed that 40 % of patients received concurrent combinations of drugs that increased the risk of muscle  damage. It is concluded that the simultaneous administration of  colchicine and statins requires an assessment of the “benefit-risk”  ratio, as well as the administration of drugs in minimally effective doses.
POST-MARKETING DRUG SAFETY RESEARCH: ANALYSIS OF RECOMMENDATIONS OF FOREIGN REGULATORS
Authors: Shubnikova E. V. , Bukatina T. M. , Kaperko D. A. , Velts N. Yu. , Darmostukova M. A. , Kazakov A. S. , Snegireva I. I. , Zhuravleva E. O. , Kutekhova G. V.
Published: September 2018

The monitoring of information on the safety of various drugs is becoming more relevant day by day, as the number of drugs on the  pharmaceutical market increases, generic drugs, bio-analogous drugs appear. Long-term post-marketing use of a  medicinal product allows to accumulate a sufficient evidence base  and experience of application in various population groups, to study  the features of the use of this drug. Information on the safe use of  new drugs can be obtained in selected scientific publications. In  addition to publications in the specialized scientific literature,  regulators of different countries on the basis of new information give opinions on the need to make changes in instructions for medical  use. When analyzing the recommendations of Russian and foreign  regulatory authorities on restricting the circulation of medicines and  / or the need to amend the instructions for their medical use in  connection with the change in the assessment of the safety profile,  we identified 16 administrative decisions of foreign regulatory bodies containing information about the following drugs registered in  Russia. We consider all recommendations to be important  information on the safety of medicines, which is addressed to  specialists in the field of medicine, in particular to persons  authorized by pharmacovigilance in pharmaceutical companies. In  addition, this information may be of interest to physicians of various  specialties who in their practice use buprenorphine, venlafaxine,  gadolinium contrast drugs hydroxyethyl starch, daclizumab,  duloxetine, denosumab, cladribine, clomifene citrate, milnacipran, methotrexate, pemetrexet, radium dichloride, rifampicin,  phoebusostat, flupirtine.
Yapma Borçlarının İcrası ve Bazı Temel Sorunlar
Authors: ERDOĞAN Ersin
Published: September 2018

Bu çalışmada, borçlunun bedenî veya fikrî emeğini ortaya koymak suretiyle

gerçekleştirdiği hareket tarzını ifade eden yapma borçlarının cebri icrası, Türk ve

Alman hukukları karşılaştırılarak incelenmiştir. Ayrıca Türk Borçlar Kanunu’nun

113’üncü maddesinde düzenlenen ve uygulama ve öğretide de nama ifa olarak

adlandırılan hüküm ile yapma borçlarının icrasını düzenleyen İcra ve İflâs

Kanunu’nun 30’uncu maddesinin birlikte nasıl uygulanabileceği tartışılmıştır.
Uluslararası Su Yollarının Kullanılmasından Doğan Uyuşmazlıkların Çözümü
Authors: EKMEN Selahaddin Eyyüp , FIRAT Muhammed Sabır
Published: September 2018

Uluslararası su yollarının kullanımından doğan uyuşmazlıklarda uluslararası

alanda kapsayıcı, kabul görmüş, uygulanan hukuk henüz oluşturulmamıştır.

Genellikle tarafların ikili ya da çok taraflı antlaşmalarıyla çözüm yoluna

gidilmektedir. Bu minvalde uygulana gelen çok taraflı antlaşmalardan birkaçı

1992 Helsinki, 1997 BM Uluslararası Su Yollarının Ulaşım Dışı Maksatlarla

Kullanımına İlişkin Sözleşme ve Avrupa Birliği Su Çerçeve Direktifidir. Gerek

bahsedilen çok taraflı sözleşmelerde olsun gerekse de devletlerin kendi aralarındaki

uyuşmazlığa ilişkin sözleşmelerde olsun çözüm noktasında kabul

görmüş belli doktrinler mevcuttur. Uyuşmazlıkların antlaşmalar dâhilinde

çözüme ulaştırılmaması halinde ise usulün elverdiği ölçüde uluslararası hukuk

normları çözüm noktasında etkili olmaktadır. Bu çalışmada Uluslararası Su

Yollarının Kullanılmasından Doğan Uyuşmazlıkların Çözümü noktasında

inceleme yapılmıştır.
Roma’da Devlete Karşı İşlenen Bazı Suçlar ve Cezaları
Authors: GÜRTEN Kadir
Published: September 2018

Bu makalede, Roma’da laik hukuk açısından devlete karşı işlenen bazı suçlar ve
bu suçu işleyenlere verilen cezalar incelenmiştir. Roma’da devlete karşı suçlar
denildiğinde akla ilk önce ağır suçlar olarak kabul edilen; vatana ihanet, vis olarak
tanımlanan isyana teşvik, makam sahiplerinin ya da bir makama gelebilmek
isteyen kişiler tarafından işlenebilecek olan haraç kesme, zimmet, seçimlere
hile karıştırma, sahte para basma suçları gelir. Bu fiillerin bir kısmı Roma’nın
ilk dönemlerinden itibaren suç olarak nitelendirilmiş, bir kısmı ise Roma’nın
ilerleyen dönemlerinde suç olarak kabul edilmiştir. Ayrıca suç olarak nitelenen
bu fiiller için düzenlenen cezalar, Roma’nın siyasi dönemlerinin koşullarına
göre ağırlaştırılmış ya da hafifletilmiştir.
Uluslararası Hukuk Komisyonunun ‘Silahlı Çatışmaların Andlaşmalara Etkisi Hakkındaki Taslak Maddeler’i Üzerine Betimsel Bir İnceleme
Authors: UZUN Elif
Published: September 2018

Silahlı çatışmaların andlaşmalara etkisi konusunda hukuki bir boşluk bulunmaktadır.

Viyana Andlaşmalar Hukuk Sözleşmesi meseleyi açıkça kapsamı dışında

bırakır. Uluslararası örf ve adet hukukunda ise kesin bir kural bulmak mümkün

değildir ve doktrindeki görüşler de farklılık gösterir. Bu makale Uluslararası

Hukuk Komisyonu’nun 2011’de tamamladığı ‘Silahlı Çatışmaların Andlaşmalara

Etkisi Hakkında Taslak Maddeler’ine dair betimsel bir inceleme sunmayı

amaçlamaktadır. Taslak Maddeler Devletlere bu sorun hakkında yönelmiş bir

öneri olarak görülebilir ve şimdiden uluslararası hukuk literatüründe bir atıf

kaynağı haline gelmiştir.
READINESS OF TEACHING AND LEARNING ENGLISH AT ELEMENTARY SCHOOLS IN MATARAM CITY
Authors: Suhirman Lalu
Published: September 2018

This research is aimed at describing the readiness of teaching-learning English at elementary school (ES) in Kodya Mataram, accentuating on perception of respondents; English teacher’s qualifications; the availability of English techer and teaching facility; students’ interest of study English; and constrains in English instruction. This survey assigns its subjects to 14 principals without EP, 49 parens of children’s schools with EP, and 55 parents of children’s schools without EP. The instruments used to collect data are questionnaire, interview guide, and observation form. The study reveals that (1) most respondents in each group are ready to teach English at ES; (2) English teachers’ qualification meet the criteria; (3) Of 30 ES without EP, 7 (23.33%) are ready, English text books for ES with are categorized mostly ready; and (4) Students at ES with are mostly ready. In addition, 9 (30%) of students at 30 non-ESP schools are totally not ready.
Obra del tiempo
Authors: Sánchez Negrette Ángela
Published: September 2018

Roberto Fernández (2007) Obra del tiempo. Introducción a la Teoría y la Práctica de la Gestión Integral del Patrimonio UrbanoArquitectónico. Ed. UNIGRAF (294 pp.). ISBN: 987224413- 8, Buenos Aires. Breve reseña del autor Roberto Fernández (1946) posee una sobrada formación académica —Doctor en Arquitectura, UBA— que a su trayectoria de docente en varias universidades agrega, hace varios años, la docencia en postgrados. Es docente y director de la Carrera de Maestría y Gestión Ambiental Urbana y la Carrera de Doctorado, ambas de la Facultad de Arquitectura de la Universidad Nacional de Mar del Plata. Ostenta una producción importante de libros y artículos sobre Historia, Crítica y lo Proyectual, siempre relacionados con su americanismo.
Brote de dermatofilosis en bovinos del altiplano de Jujuy, Argentina
Authors: Marin R. E. , Saez J. , Saez V.
Published: September 2018

Se describe un brote de dermatofilosis (Dermatophilus congolensis) en bovinos de la puna de Jujuy. El cuadro se presentó en un rodeo bovino criollo nativo, durante la estación lluviosa en el verano climático de la región. Los animales afectados presentaron dermatitis exudativa proliferativa no pruriginosa con formación de costras, afectando el espacio interdigital de los cuatro miembros, y en forma severa y localmente extensiva en los miembros posteriores y el interior de las fosas nasales. El diagnóstico se realizó en base a la presentación clínica, la identificación del agente causal en frotis obtenido del material dérmico, y las características epidemiológicas, considerando que los factores climáticos y las condiciones de manejo favorecieron la presentación de la enfermedad
Opinião de cirurgiões dentistas sobre atividades de preceptoria na formação de estudantes de Odontologia de uma universidade brasileira
Authors: Lopes Pablo Erik da Silva , Carvalho Elaine Judite de Amorim , Souza Fábio Barbosa de , Jamelli Sílvia Regina , Melo Márcia Maria Dantas Cabral de
Published: September 2018

O objetivo deste estudo foi conhecer a opinião de cirurgiões-dentistas sobre a atividade de preceptoria desempenhada por eles nos estágios curriculares 1, 2 e 3 do curso de Odontologia da Universidade Federal de Pernambuco, realizados em unidades da Atenção Básica à Saúde no município de Recife. Realizou-se estudo descritivo e de abordagem quantitativa. De um universo de 36 cirurgiões-dentistas foram incluídos aqueles com no mínimo um ano de experiência como preceptor. Para a coleta de dados utilizou-se formulário de entrevista semiestruturada, submetido à validação de face e aplicado face a face. Todos os 26 preceptores que atenderam ao critério de inclusão foram entrevistados, sendo 80,8% mulheres; 92,3% com vínculo de trabalho efetivo; 96,2% pós-graduados, sendo 80,2% deles especialistas em Saúde da Família. Apenas 15,4% recebiam incentivos para preceptoria, mas não estavam satisfeitos; 11,2% receberam formação em preceptoria; 92,3% demandaram capacitação para exercê-la; 69,2% atuaram nos três tipos de estágios. Prevaleceu (76,3%) a preferência por atuar no estágio 3 (clínico) do que nos dois outros (extra-clínicos). Para 65,3% deles a estrutura física e organizacional para exercer a preceptoria é ruim, 69,2% avaliaram como insatisfatório o apoio institucional do serviço e 57,7% o da universidade, apesar dos esforços da instituição formadora em promover educação permanente e presencial nos serviços. Os pontos positivos mais citados foram a troca de saberes com os estudantes e docentes e a importância de integrar o estudante ao Sistema Único de Saúde. Conclui-se que embora valorizem a preceptoria, prevaleceram insatisfações de ordem trabalhista, de condições de trabalho e de formação que precisam ser enfrentadas.
Cost, outcomes, use, and perceptions of Open Educational Resources in psychology: A narrative review of the literature
Authors: Clinton-Lisell Virginia
Published: September 2018

Open educational resources (OER) have been developed to free students from the expense and instructors from the restrictions of commercial materials. There has been a wealth of empirical examination on numerous aspects of OER. The purpose of this narrative review is to synthesize and integrate the findings on OER in psychology to assist instructors in making informed decisions about course materials. Topics in this review were organized according to the COUP framework of cost, outcomes, use, and perceptions. Results indicated that OER adoption yielded cost savings while generally having similar or better outcomes in terms of grades. Students typically reported similar use and perceptions of OER compared to commercial course materials. Resources for instructors interested in OERs are described. Criticisms of OER, such as concerns about quality, are addressed as well as limitations of reviewed research and future directions for research and development of OER.
Cohort Profile: Children in Need Census (CIN) records of children referred for social care support in England (Pre-Print)
Authors: Emmott Emily H , Jay Matthew , Woodman Jenny
Published: September 2018

Purpose: CIN is a case-based administrative dataset on children referred to social care services in England. CIN includes information on the ‘needs’ of children, and whether they received social care support. Local and national government bodies in England currently use CIN for evaluation purposes. Data is accessible to researchers under certain conditions, allowing researchers to investigate health implications of adverse childhood experiences. However, CIN suffers from lack of metadata, meaning it can be challenging for researchers to process and interpret data, particularly if researchers are unfamiliar with the English children’s social care system. To address this issue, we provide the background to CIN and describe the available data from 2008 to 2016.Participants: CIN is derived from case records held by English Local Authorities on all children referred to children’s social care for a ‘needs assessment,’ regardless of whether they are eventually assessed as ‘in need of social care support.’ Local Authorities submit these case records to the UK Department for Education for collation. CIN holds information on an estimated 2.76 million children from October 2008 to March 2016. Since 2013/14, just under 900,000 children have been recorded in the CIN annually, equivalent to around 8% of children in England (annual prevalence). Approximately 650,000 children enter or renter the dataset each year, equivalent to 5% of children in England (annual incidence). Data summary: Of the estimated 2.76 million children in the data, 50% are male and 47% female. 45% are referred to children’s social care services due to abuse or neglect. 10.7% of children in CIN went onto a child protection plan, meaning they were judged to be (at risk of) suffering significant harm.Future Plans: CIN data collection is annual and ongoing. Data from the most recent census period typically becomes available for researchers in the following Spring.
A nationwide regional flood frequency analysis at ungauged sites using ROI/GLS with copulas and super regions
Authors: Durocher Martin , Burn Donald , Zadeh Shabnam
Published: September 2018

Region of influence is a common approach to estimate runoff information at ungauged locations. To estimate flood quantiles from annual maximum discharges, the Generalized Least Squares (GLS) framework has been recommended to account for unequal sampling variance and intersite correlation, which requires a proper evaluation of the sampling covariance structure. Since some jurisdictions do not have clear guidelines to perform this evaluation, a general procedure using copulas and a nonparametric intersite correlation model is investigated to estimate sampling covariance structure in situations where no common at-site distribution is imposed or when some paired sites do not have common periods of record. The investigated methodology is applied on 771 sites in Canada. The Normal copula is verified to be an adequate model that better fit paired observations than other types of extreme copulas. A sensitivity analysis is carried out to evaluate the impact of either ignoring, or considering a simpler form of, intersite correlation. Additionally, super regions are defined based on drainage area and mean annual precipitation to improve the calibration of pooling groups across large territories and a wide range of climate conditions. Performance criteria based on cross-validation revealed that using super regions and a combination of geographic distance and similarity between catchment descriptors improves the calibration of the pooling groups by providing more accurate estimates.
Mechanisms of prediction updating - preprint
Authors: Szewczyk Jakub M. , Wodniecka Zofia
Published: September 2018

One of the most compelling pieces of evidence for the presence of predictions in language comprehension comes from event-related potential (ERP) studies which show that encountering an adjective whose gender marking is inconsistent with that of a highly expectable noun leads to an effect at the adjective. Until now the mechanism underlying this effect has been unknown. The present study tests a novel hypothesis whereby the effect at adjectives reflects prediction updating, which in turn impacts the N400 generated by the upcoming noun. In two experiments, native speakers of Polish read short stories that made several nouns likely at the position of a direct object in the story’s final sentence. The noun was preceded by a gender-marked adjective which was shown in either of the two grammatical forms: a) informative about the following noun (adjectival gender marking constrained which nouns can follow), or b) less informative (the grammatical marking did not disambiguate the gender of the following noun). Importantly, the same stories and critical words were used in both conditions, which was possible thanks to exploiting syncretisms in Polish adjectival inflection. The results provide support for one or more mechanisms of prediction updating at the adjective that impact the amplitude of the N400 elicited by the following noun. Together, these results show that when only morphosyntactic cues are available, they are instantly used to update predictions about upcoming words.
When Do Motivational Factors Lead to Negative User Experience on Social Networking Applications?
Authors: Huang Shin-Yi , Yang Miles M. , Chen Chien-Hsiung
Published: September 2018

We investigate why some innovative user interface (UI) designs (e.g., Facebook Home), although initially expected to encourage users to accept or adopt social networking applications (apps), actually discouraged users from using those applications over time. Using two experimental studies, we explore the relationship between new design factors and user behavioural intentions. In Study 1, we adopted two-factor theory to discover motivational factors related to using a social networking app. We then designed and created a virtual social networking app (called Unicorn) using these identified motivational factors. In Study 2, we investigated how motivational factors de-motivate user behavioural intentions. We unpacked this relationship using the Technology Acceptance Model (TAM). Further, we explored how involvement level may alleviate this negative relationship. Our results show that users with a high involvement level exhibit a relatively high level of perceived usefulness and perceived playfulness. Therefore, involvement level can alleviate the negative relationship that exists between motivational factors and behavioural intentions. This study provides both theoretical implications to the literature and practical insights for UI designers.