bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFECTIVENESS OF LOCAL TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES IN WOMEN WITH PREGNANCY COMPLICATED BY HESTOSIS
Authors: Чуйкин Сергей , Chuykin Sergey , Акмалова Гузель , Akmalova Guzel' , Егорова Елена , Egorova Elena , Маганова Зарема , Maganova Zarema
Published: October 2019

For a woman’s dental health, pregnancy is a critical period, characterized by an exacerbation of inflammatory periodontal diseases before pregnancy, as well as a significant increase in dental caries. Using a significant group of drugs during pregnancy is not safe for a woman's body. In this regard, in the treatment of periodontal diseases, the inclusion of phytopreparations into the complex of treatment and prophylactic measures that can restore local immunity, reduce inflammation and accelerate the restoration of the mucous membrane, which have minimal side effects on the body as a whole, is of great importance.

The aim of the work was to assess the clinical effectiveness of the local use of a new chewing phytosubstrate containing beeswax and dry aqueous boron extract, consisting of oak bark, alder fruit, birch buds, chamomile flowers and thyme grass in women with gingivitis with gestosis complicated pregnancy.

Methods. A survey was conducted of 127 pregnant women, of which 79 pregnant with gestosis and 48 patients with a physiological course of pregnancy at the age of 18-34 years in the II and III trimesters.

Results. The dental status and physicochemical properties of the oral fluid in women with gestational complications of pregnancy were studied before and after the application of the new phytosubstrate.

Conclusions. The chewing substrate containing beeswax and dry aqueous extract consisting of oak bark, alder fruit, birch buds, chamomile flowers and thyme herbs has been found to be highly effective in the prevention and treatment of gingivitis in women with gestosis complicated pregnancy, which was confirmed by improved biochemical and physico-chemical indicators of oral fluid, as well as clinical indicators of dental status. in women with gestational complications.
Kaymakam Mehmed Hüsnü Bey’in Raporuna Göre 19. Yüzyıl Sonunda Bayburt Kazasının Genel Durumu
Authors: YILDIRIM Yıldıray
Published: October 2019

Osmanlı
Devleti’nde 1864 Vilayet Nizamnamesi, idari yapılanmayı yeniden düzenlemişti.
Bu düzenleme ile kazalara yönetici olarak kaymakamlar atanmaya başlandı.
Kaymakamlar atandıkları yerlerin kalkınması ve merkezde oluşturulan yeni
kurumların buralarda da tesisi için çaba sarf etmekteydi. Bu kişilerden biri de
Bayburt Kaymakamı Mehmed Hüsnü Bey’di. Ocak 1897 tarihinde Bayburt’a atatan
Mehmed Hüsnü Bey, Rumi 1315 yılında Anadolu Vilayetleri Umum Müfettişliğine
Bayburt kazasının 1314 (1898-1899) yılına dair genel durumunu ortaya koyan bir
istatistik hazırladı. İstatistik; mülkiye, maliye, nafıa, maarif, adliye,
muhabere ve belediyeye ait bilgiler içermekteydi. Mehmed Hüsnü Bey’in
hazırlamış olduğu istatistik temelinde oluşturulan bu çalışmada, XIX. yüzyılın
sonunda kazanın idari yapılanması ve kurumları, kaza nüfusu ile bunun niteliği,
maliyeye ait gelir-gider durumu, tarım ve hayvancılık ile mülk satışları, başta
Ziraat Bankası olmak üzere nafıanın mali durumu, kazada mevcut modern eğitim
kurumları ve belediyenin durumu değerlendirilmeye çalışıldı. İstatistikteki
bilgileri desteklemek ve bazı konuları detaylandırmak amacıyla, döneme ait
salnamelerden de önemli ölçüde faydalanıldı. Böylelikle bu çalışma, Bayburt kazasının
XIX yüzyıl sonlarındaki genel durumunu ortaya koymayı amaçlamaktadır.
Globalization and Civil Society or “Global Civil Society”
Authors: AKSAN Gamze
Published: October 2019

The idea of civil society has brought along various
meanings and concepts in the historical process. Civil society, which gained
more importance with the modern era, has gained a complex structure with
globalization, which is a much more visible process in the 21st century. In
particular, cultural diversity, the existence and demands of different social
groups in social life, social movements, transportation and communication
facilities; differentiated globalization and civil society. This, in a way, has
led to a broader reading of political life. In this study, the ties and
relationship between globalization, a historical process and reality, and the
concept of civil society emerged in the 21st century has been tried to be revealed.
For this purpose, the historical development of civil society has been included
in the study. In the following sections, the issue of globalization,
democratization and civil society has been discussed and finally, inferences
regarding the perception of global civil society which constitute the body of
the study have been made.
Türkiye Cumhuriyeti’nin İlk Maliye Bakanı Gümüşhane Milletvekili Hasan Fehmi Ataç’ın Mali Alandaki Faaliyetleri
Authors: ÖZYÜREK Mustafa
Published: October 2019

1879’da
Gümüşhane’de doğan Hasan Fehmi Bey, başladığı ilk ve orta öğrenimini
İstanbul’da tamamlamıştır.  Çeşitli
görevlerde bulunduktan sonra Osmanlı Mebusan Meclisinde 18 Nisan 1912-5 Ağustos
1912 ile 15 Şubat 1913-21 Aralık 1918 tarihleri arasında iki dönem Gümüşhane
mebusluğu yapmıştır. Daha sonra Ankara’ya geçerek Mustafa Kemal Paşa’nın
yanında Millî Mücadeleye katılmıştır. Türk siyasi hayatında çok önemli bir yere
sahip olan Hasan Fehmi Ataç’ın en önemli hizmeti kuşkusuz Millî Mücadele
Dönemi’nde 19 Mayıs 1921-9 Temmuz 1922 tarihleri arasında yaptığı maliye
vekilliğidir. Çünkü devletin kısıtlı gelirlerine rağmen Türk ordusunun hemen
hemen bütün ihtiyaçlarını karşılamayı başarmıştır. Doğu ve Batı orduları için
iki ayrı defterdarlık kurarak subay maaşlarının düzenli olarak ödenmesini
sağlamış, ayrıca Büyük Taarruz’un finans kaynaklarını temin ve organize
etmiştir. Hasan Fehmi Bey, Türkiye Büyük Millet Meclisinin açılmasından
itibaren ilk sekiz dönem boyunca Gümüşhane milletvekilliği yapmıştır.  1 Kasım 1923-2 Ocak 1924 tarihleri arasında
cumhuriyet tarihinin ilk maliye vekilliği görevinde bulunmuş, daha sonra
1924-1925 yıllarında ise ziraat vekilliği yapmıştır. Sonraki yıllarda anayasa,
bütçe ve maliye komisyonlarında görev almış ve 1961’de vefat etmiştir.
On a dilation of a some class of completely positive maps
Authors: ELSAEV Yakub V.
Published: October 2019

In this article we investigate sesquilinear forms defined on the Cartesian product of Hilbert C^*-module M over C^*-algebra B and taking values in B. The set of all such defined sesquilinear forms is denoted by S_B (M). We consider completely positive maps from locally C^*-algebra A to S_B (M). Moreover we assume that these completely positive maps are covariant with respect to actions of a group symmetry. This allow us to view these maps as generalizations covariant quantum instruments which are very important for the modern quantum mechanic and the quantum field theory. We analyze the dilation problem for these class of maps. In order to solve this problem we construct the minimal Stinespring representation and prove that every two minimal representations are unitarily equivalent.
Besides and Beyond Flowering: Other Roles of euAP2 Genes in Plant Development
Authors: Solomon Charles U. , Drea Sinead
Published: October 2019

EuAP2 genes are famous for their role in flower development. A legacy of the founding member of this subfamily of transcription factor, whose mutants lacked petals in Arabidopsis. However, studies of other euAP2 genes in several species have accumulated evidence highlighting the diverse roles of euAP2 genes in other aspects of plant development. Here, we emphasize other developmental roles of euAP2 genes in various species and suggest a shift from regarding euAP2 genes as just flowering genes to consider the global role they may be playing in plant development. We hypothesize that their almost universal expression profile and pleiotropic effects of their mutation suggest their involvement in fundamental plant development processes.
Application of Local Gauge Theories to Fluid Mechanics
Authors: Merz Thomas
Published: October 2019

The problem of fluid dynamics can be greatly simplified if, for every point in space, the strain-rate tensor is diagonalized. This tensor is introduced into the Navier-Stokes equations via material law and divergence of the stress tensor. This article shows that local SO(3)xU(1) gauge fields can be used to locally diagonalize the diffusion components of the strain-rate tensor. The gauge fields resulting from the connection can be interpreted as convection components of the flow, they show properties of quasiparticles and can be interpreted as elementary vortices. Thus, the proposed approach not only offers new insights for the solution and situative simplification of the Navier-Stokes equations, it also uncovers hidden symmetries within the flow convection, allowing - depending on boundary conditions - further interpretation.
A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer
Authors: Vankova Pavla , Salido Eduardo , Timson David J. , Man Petr , Pey Angel L.
Published: October 2019

Human NAD(P)H:quinone oxidoreductase 1 (NQO1) is a multi-functional protein whose alteration is associated with cancer, Parkinson´s and Alzheimer´s diseases. NQO1 displays a remarkable functional chemistry, capable of binding different functional ligands that modulate its activity, stability and interaction with proteins and nucleic acids. Our understanding on this functional chemistry is limited by the difficulty of obtaining structural and dynamic information on many of these states. Herein, we have used hydrogen/deuterium exchange monitored by mass-spectrometry (HDXMS) to investigate the structural dynamics of NQO1 in three ligation states: without ligands (NQO1apo), with FAD (NQO1holo) and with FAD and the inhibitor dicoumarol (NQO1dic). We show that NQO1apo has a minimally stable folded core holding the protein dimer and with FAD and dicoumarol ligand binding sites populating binding non-competent conformations. Binding of FAD significantly decreases protein dynamics and stabilizes the FAD and dicoumarol binding sites as well as the monomer:monomer interface. Dicoumarol binding further stabilizes all three functional sites, a result not previously anticipated by available crystallographic models. Our work provides an experimental perspective into the communication of stability effects through the NQO1 dimer, valuable to understand at the molecular level the effects of disease-associated variants, post-translation modifications and ligand binding cooperativity in NQO1.
Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge
Authors: Reis Nayara Araújo dos , Rodrigues Rosalina Aparecida Partezani , Tavares Darlene Mara dos Santos , Fhon Jack Roberto Silva , Virtuoso Júnior Jair Sindra
Published: October 2019

C-reactive protein (CRP) and leukocytes are blood biomarkers involved in "Inflamm-Aging", which is a risk factor for the onset and progression of age-related diseases. Studies show that higher serum concentrations of these biomarkers are associated with functional disability, increased risk of low muscle strength, decreased muscle mass and mortality in the elderly. The objective was to estimate the predictive power and discriminating criteria of C-reactive protein and leukocyte concentrations for the risk of adverse health factors in the elderly within 30 days after hospital discharge (HD). Prospective cohort study using exploratory methods and blood biomarkers with 135 older adults admitted to medical and surgical clinics at a government hospital. The elderly were monitored at home after 30 days of HD for adverse health factors (rehospitalization, falls, amount of medication consumed, disability in basic and instrumental activities of daily living and mortality). CRP> 2.4; ≥ 0.7 and> 24.7 mg / dL and leukocytes ≥ 6.410; ≥ 8.690 and> 8.310 mm³ were discriminant for rehospitalization, falls and mortality within 30 days after HD, respectively. The cut-off points described may be used as a reference in the screening of hospitalized elderly vulnerable to adverse health events after hospital discharge.
Analysis of Raindrop Shapes, Fall Velocities, and Scattering Calculations during Tropical Storm Nate
Authors: Thurai Merhala , Steger Sophie , Teschl Franz , Schoenhuber Michael
Published: October 2019

Tropical storm Nate, which was a powerful hurricane prior to landfall along the Alabama coast, traversed north towards our instrumented site in Hunstville, AL. The rain bands lasted 18 h and the 2D-video disdrometer (2DVD) captured the event which was shallow and indicative of pure warm rain processes. Measurements of raindrop size, shape and velocity distributions are quite rare in pure warm rain and are expected to differ from cold rain processes. In particular, asymmetric shapes due to drop oscillations and their impact on polarimetric radar signatures in warm rain have not been studied so far. Recently, the 2DVD data has been used for 3D reconstruction of asymmetric raindrop shapes but their fraction (relative to the more common oblate shapes) in warm rain has yet to be ascertained. Here we compute the scattering matrix drop-by-drop using Computer Simulation Technology integral equation solver for drop sizes>2.5 mm. From the scattering matrix elements, the polarimetric radar observables are simulated by integrating over 1 minute consecutive segments of the event. These simulated values are compared with dual-polarized C-band radar data located at 15 km range from the 2DVD site to evaluate the contribution of the asymmetric drop shapes.
Study on the Removal of Fluorescent Whitening Agent for Paper-mill Wastewater Reuse using the Submerged Membrane Bioreactor (SMBR) with Ozone Oxidation Process
Authors: Choi Jang-Seung , Shin Dong-Hoon , Ryu Seung-Han , Ryu Jae-Young , Shin Won-Sik , Park Min-Soo , Kim Jin-Ho , Heo Jae-Eun
Published: October 2019

In this study, effluent water was produced through Submerged Membrane Bio-Reactor (SMBR) process, which is a simple system and decomposes organic matter contained in wastewater with biological treatment process and performs solid-liquid separation, Especially, ozone oxidation treatment process is applied to effluent water containing fluorescent whitening agent, which is a trace pollutant which is not removed by biological treatment, and influences the quality of reused water. The concentration of COD in the SMBR was 449.3 mg/ℓ-COD, and the concentration of permeate water was 100.3 mg/ℓ-COD. The removal efficiency was about 70.1%. The amount of ozone re- quired for the removal of the fluorescent whitening agent in the permeated water in SMBR was 6.67 g-O3/min, and the amount of ozone required to remove COD relative to the permeate water was calculated to remove 0.997 mg-COD for 1 mg of O3.
MEMBENTUK KARAKTER BANGSA SEJAK USIA DINI
Authors: Istati Dwi
Published: October 2019

Early childhood period is a golden age, where at this time aspects of child development very rapidly, including in order to shape their character. Character education is complex education because it involves aspects of cognitive, feeling, and action. Character education is based on basic human character, which comes from universal moral values (absolute) derived from religion which is also referred to as the golden rule. Character education can be taught systematically in a holistic education model using the method of knowing the good, feeling the good, and acting the good. Character will be formed as a result of understanding 3 relationships that must be experienced by every human being (triangle relationship), namely the relationship with oneself (intrapersonal), with the environment (social and natural relationships), and relationships with God (spiritual).

Abstrak

Masa usia dini adalah masa emas, dimana pada masa ini aspek-aspek perkembangan anak berkembang sangat pesat, termasuk di dalamnya adalah masa emas dalam rangka membentuk karakternya. Pendidikan karakter adalah pendidikan budi pekerti plus, yaitu yang melibatkan aspek pengetahuan (cognitive), perasaan (feeling), dan tindakan (action). Pendidikan karakter berpijak dari  karakter dasar manusia, yang bersumber dari nilai moral universal (bersifat absolut) yang bersumber dari agama yang juga disebut sebagai the golden rule. Dan dapat diajarkan secara sistematis dalam model pendidikan holistik menggunakan metode knowing the good, feeling the good, dan acting the good. Karakter akan terbentuk sebagai hasil pemahaman 3 hubungan yang pasti dialami setiap manusia (triangle relationship), yaitu hubungan dengan diri sendiri (intrapersonal), dengan lingkungan (hubungan sosial dan alam sekitar), dan hubungan dengan Tuhan YME (spiritual).
PEMBUATAN PROGRAM PENYULUHAN PERAWATAN KEBERSIHAN DIRI (PERSONAL HYGIENE) BERBASIS LIFE SKILL UNTUK ANAK PRASEKOLAH DI PANTI SOSIAL ASUHAN ANAK
Authors: Jubaedah Yoyoh , Neni Rohaeni  , Afifah Azzahra
Published: October 2019

This main reason of this reseaserch is the absence of treatment programs particularlly personal hygiene and cleanliness  based on the life skill for preschooler in social childcare institutions or orphanage.The elucidation care of personal hygiene and cleanliness  is aims to help extension to the provision concerning the treatment personal hygiene and cleanliness for them. The purpose of this research is to produce a counseling program of personal hygiene and cleanliness care based on the life skill for children in social institution of preschooler in the form of a guidebook. This study use of research and development with the research PPE approach covering planning, production, and evaluation. The explicitness directness on the socialization program to care cleanliness (personal hygiene) based on the life skill for preschooler is in very reasonable criteria, such as program consists of identity, the purpose, matter, method, scenario, activities, and evaluation. Recommendations for the next researchers and care instution management is to implement and use the book of cleanliness and personal hygiene program for preschooler with feasibility be able to be as a guide to theses treatment programs based on the life skill for them in social institutions.

Abstrak

Penelitian ini dilatarbelakangi belum adanya program perawatan kebersihan diri (personal hygiene) berbasis life skill untuk anak prasekolah di Panti Sosial Asuhan Anak (PSAA). Penyuluhan perawatan kebersihan diri (personal hygiene) untuk anak prasekolah ini bertujuan untuk membantu penyuluh dalam memberikan pembekalan mengenai perawatan kebersihan diri (personal hygiene) untuk anak prasekolah (usia 3-6 tahun). Tujuan dari penelitian ini adalah untuk menghasilkan program penyuluhan perawatan kebersihan diri (personal hygiene) berbasis life skill untuk anak prasekolah di Panti Sosial Asuhan Anak dalam bentuk Buku Panduan. Penelitian ini menggunakan metode Research and Development (R&D) dengan model penelitian PPE yang meliputi Planning, Production, dan Evaluation. Hasil expert judgment mengenai program penyuluhan perawatan kebersihan diri (personal hygiene) berbasis life skill untuk anakprasekolah berada pada kriteria sangat layak terdiri atas: identitas program, tujuan, materi, metode, skenario kegiatan, dan evaluasi program. Rekomendasi untuk pengelola PSAA dan peneliti selanjutnya, hendaknya program penyuluhan perawatan kebersihan diri (personal hygiene) untuk anak prasekolah yang telah memiliki kelayakandapat diimplementasikan serta dijadikan panduan pelaksanaan program perawatan kebersihan diri (personal hygiene) berbasis life skill untuk anak prasekolah di Panti Sosial Asuhan Anak (PSAA).
TREATMENT FOR STUDENTS WITH LEARNING DISABILITY THAT CAN BE DONE BY BOTH TEACHERS AND PARENTS: A LITERATURE REVIEW
Authors: Rusmono Danny
Published: October 2019

Inclusion education program has been implemented in Indonesia, which means schools are obliged to accept students with special needs. Students of said category perieved as a particular burden by their teachers. Teachers said that it was because they are lacking in experience to handle said students and they did not graduate from special education program in college. Aside from teachers, there are parents who are still lacking in information about the condition of their children. The present reserarch aims to find treatments suitable for teachers and parents to do to children with learning disabilities. The search of e-literatures was conducted to identify journals published from 2009 to 2019 concerning treatments that are suitable for teachers and parents to do. Electronic databases used were ScienceDirect, Proquest, Springer and SAGE. There were 6 studies used in this research after excluding studies that did not match to criteria used in this review. Treatments that can be done by both teachers and parents to students with learning disabilities are Group Intervention, Teacher-made Instruction Material, Homeschooling, Phonology and Orthography. The outcome of using those treatments is that students show improved skills to do what they have been struggling with and catching up with their peers.

 

Abstrak

Pendidikan inklusi sudah diberlakukan di Indonesia. Artinya semua sekolah wajib menerima siswa berkebutuhan khusus. Guru mendapati siswa berkebutuhan khusus membawa beban dalam pengajarannya. Hal tersebut dikarenakan guru yang kurang berpengalaman atau guru tidak berasal dari pendidikan luar biasa. Selain guru yang kurang dapat menangani siswa berkebutuhan khusus, orang tua juga masih ada yang kurang memahami kondisi anaknya. Penelitian ini bertujuan untuk menemukan penanganan apa yang bisa dilakukan oleh orang tua dan guru. Pencarian literatur elektronik yang diterbitkan dalam 10 tahun terakhir mengenai penanganan yang dapat dilakukan oleh orang tua dan guru. Database elektronik yang digunakan adalah ScienceDirect, Proquest, Springer, Sage. Ada 6 studi yang digunakan setelah adanya seleksi menurut kriteria yang sudah ditetapkan. Ada beberapa penanganan yang dapat dilakukan bagi siswa dengan learning disability seperti group intervention, teacher-made instruction material, homeschooling, phonology dan ortography. Dari penanganan yang telah disebutkan, hasilnya adalah siswa dengan learning disability menunjukkan kemampuan belajar yang membaik, dan mampu mengejar ketertinggalan mereka dengan teman sebayanya.
A MODEL FOR CONSUMER TRUST IN E-COMMERCE
Authors: Mohammad Falahat  , Yan-Yin Lee  , Yi-Cheng Foo  , Chee-En Chia
Published: October 2019

E-commerce has grown rapidly over the past decade and has become a significant trend. One of the major concerns for the successful proliferation of e-commerce is the issue of consumers’ trust in Internet vendors. This study examines the antecedents of trust in e-commerce among Malaysian online consumers. Data was collected from 300 respondents who had recently made online purchases. Structural equation modelling-partial least squares (SEM-PLS) was used to analyse the data, and our findings reveal that brand recognition, service quality, security, and word-of-mouth (WOM) lead to higher levels of consumer trust, whereas customer satisfaction has an insignificant relation to consumer trust. This study enables online vendors or e-commerce business owners to understand consumer demand and satisfy their needs. Strategies need to be set right too to attract more consumers in purchasing online.
Kitosan-Vişne Çekirdeği Kabuğu Pirolitik Çarı Kompozit Boncuklarının Sentezi ve Karakterizasyonu: Cr(VI) Gideriminde Kullanılması
Authors: ALTUN Türkan , ECEVİT Hüseyin
Published: October 2019

Bu çalışmada, vişne çekirdeği kabuğu pirolitik çarı (VÇKÇ) elde edilmiş ve bu pirolitik çarın kitosanla karıştırılarak boncukların oluşturulması yoluyla kitosan/pirolitik çar kompozit boncukları (K-VÇKÇ) sentezlenmiştir. Sonrasında VÇKÇ ve K-VÇKÇ boncuklarının sulu çözeltilerden Cr(VI) adsorpsiyonları karşılaştırmalı olarak incelenmiştir. Kesikli adsorpsiyon deneyleri sonucunda; Cr(VI) giderimi için optimum adsorban miktarı VÇKÇ için 5 g/L, K-VÇKÇ için ise 1,5 g/L; optimum pH VÇKÇ için 1,56, K-VÇKÇ için 2, optimum temas süresi 120 dk olarak belirlenmiştir. VÇKÇ ve K-VÇKÇ adsorbanları için adsorpsiyona, Langmuir İzoterm modelinin en uygun model olduğu görülmüştür. Bu izotermden, maksimum adsorpsiyon kapasiteleri VÇKÇ için 14,455 mg/g ve K-VÇKÇ için 86,298 mg/g olarak hesaplanmıştır. Termodinamik hesaplamalar, adsorpsiyonun endotermik ve istemli olduğunu göstermiştir. Adsorpsiyon kinetiği üzerine yapılan hesaplamalar sonucunda adsorpsiyonun yalancı ikinci mertebeden kinetik model ile uyumlu olduğu görülmüştür. Sentezlenen adsorbanların karakterizasyonu SEM/EDX, BET, FTIR ve elementel analiz ile gerçekleştirilmiştir. SEM/EDX ve FTIR analizleri ile Cr(VI)’nın adsorplandığı kanıtlanmıştır. Bu çalışma, VÇKÇ ve K-VÇKÇ’nin sulu çözeltilerden Cr(VI) gideriminde düşük maliyetli ve etkili bir adsorban olabileceğini göstermiştir. 
The impact of climatic changes on total horticultural production and food security in agro-ecological zones of Iran
Authors: Barani Nader , Karami Ayatollah , Borazjani Mahmoud Ahmadpour
Published: October 2019

Arid and semi-arid climates, including that of Iran, are more susceptible to environmental changes due to their special ecological structure than other climates. Therefore, climate change in these areas appears to have significant effects on agricultural and food production systems. The present study explores the effect of climatic changes on total horticultural production and food security in agro-ecological zones of Iran. The study was conducted in two steps. In the first step, the effects of climatic parameters on total horticultural production were investigated using time series data (1985–2017) and a regression model. In the second step, due to the important role of horticultural products in per capita food consumption in Iran, the effect of climate parameters on food security was also examined. Results revealed that total horticultural production was influenced by temperature, evapotranspiration, and wind speed at the 0.05 level. With the increase in temperature (at a rate of one unit), total horticultural production is reduced to 0.01 million tons. Evapotranspiration and wind speed have had a negative effect on total horticultural production, and with increasing evapotranspiration and wind speed, total horticultural production was 0.029 and 0.008 million, respectively, tons decreased. Also, food security was influenced by temperature, precipitation, and wind speed.
New and Promising Chemotherapeutics for Emerging Infections Involving Drug-resistant Non-albicans Candida Species
Authors: Silva Laura Nunes , de Mello Thaís Pereira , de Souza Ramos Lívia , Branquinha Marta Helena , dos Santos André Luis Souza
Published: October 2019

Fungal infections are a veritable public health problem worldwide. The increasing number of patient populations at risk (e.g. transplanted individuals, cancer patients, and HIV-infected people), as well as the use of antifungal agents for prophylaxis in medicine, have favored the emergence of previously rare or newly identified fungal species. Indeed, novel antifungal resistance patterns have been observed, including environmental sources and the emergence of simultaneous resistance to different antifungal classes, especially in Candida spp., which are known for the multidrug-resistance (MDR) profile. In order to circumvent this alarming scenario, the international researchers’ community is engaged in discovering new, potent, and promising compounds to be used in a near future to treat resistant fungal infections in hospital settings on a global scale. In this context, many compounds with antifungal action from both natural and synthetic sources are currently under clinical development, including those that target either ergosterol or β(1,3)-D-glucan, presenting clear evidence of pharmacologic/pharmacokinetic advantages over currently available drugs against these two well-known fungal target structures. Among these are the tetrazoles VT-1129, VT-1161, and VT-1598, the echinocandin CD101, and the glucan synthase inhibitor SCY-078. In this review, we compiled the most recent antifungal compounds that are currently in clinical trials of development and described the potential outcomes against emerging and rare Candida species, with a focus on C. auris, C. dubliniensis, C. glabrata, C. guilliermondii, C. haemulonii, and C. rugosa. In addition to possibly overcoming the limitations of currently available antifungals, new investigational chemical agents that can enhance the classic antifungal activity, thereby reversing previously resistant phenotypes, were also highlighted. While novel and increasingly MDR non-albicans Candida species continue to emerge worldwide, novel strategies for rapid identification and treatment are needed to combat these life-threatening opportunistic fungal infections.
A Importância do Inglês na Medicina e no Desenvolvimento Profissional/ The Importance of English in Medicine and in the Professional Development
Authors: Posegger Karin Romano
Published: October 2019

Com o rápido avanço da tecnologia fomos cercados por uma infinidade de aplicativos, vídeos tutoriais, e acesso a diversas fontes de informações e pesquisa, como o acesso a artigos científicos, notícias, documentários, cursos e outros. Nunca foi tão fácil estarmos conectados com o mundo. Com tudo isso, é impossível não percebermos que o idioma inglês se tornou a principal ferramenta neste processo de evolução, ou seja, o idioma “oficial” que nos conecta às oportunidades e aprendizado, pois não há como nos limitarmos ao conteúdo nacional. Mas, será que estamos preparados para falarmos em inglês?O domínio desse idioma tornou-se necessário em quase todos os setores, sendo indispensável na Medicina, trazendo para a superfície a importância do investimento no aprendizado e fluência.O profissional médico destaca-se no mercado de trabalho quando consegue estar atualizado através da leitura de artigos científicos, participação em congressos, workshops, seminários e cursos, produzidos em sua maioria em inglês. Mas, maior destaque pode ser alcançado quando o profissional tem a possibilidade de participar de shadowings,observerships, fellowshipse pós-graduação no exterior.
Exploring the Views of Osteogenesis Imperfecta Caregivers on Internet-Based Technologies: Qualitative Descriptive Study
Authors: Castro Aimee R , Chougui Khadidja , Bilodeau Claudette , Tsimicalis Argerie
Published: October 2019

Background

Osteogenesis imperfecta (OI) is a rare genetic condition that can lead to frequent debilitating bone fractures. Family caregivers of children with OI face unique challenges in providing care, which may include limited access to information about the condition, feelings of distress, and experiences of social isolation. Internet-based technologies (IBTs) have been useful for supporting other types of caregivers. However, the views of OI caregivers on IBTs have not been explored.

Objective

This study aimed to explore the views of OI caregivers on the uses of IBTs to support them in caring for their children with OI.

Methods

A qualitative descriptive study was conducted. Caregivers of children with OI were recruited at a pediatric hospital in Montreal, Canada. Interviews were used to explore each caregiver’s views on the applicability of IBTs in supporting their caregiving needs. The interviews were transcribed verbatim and thematically analyzed.

Results

A total of 18 caregivers participated. The caregivers shared that IBTs were useful for facilitating the following activities: daily activities of caregiving (such as providing physical care, supporting relationships, supporting self-care and hope, and managing the logistics of caregiving), OI medical information seeking, and OI social networking. However, they also revealed concerns about the health consequences of IBT use and the quality of IBT content. Concerns regarding IBTs varied somewhat with caregivers’ geographies. Caregivers offered suggestions and strategies for how IBTs can be optimized for caregiving.

Conclusions

Family caregivers of children with OI face unique challenges in providing care, which may include lacking access to information about the rare condition and feeling socially isolated. OI caregivers use IBTs to overcome some of these challenges and to support their specific caregiving needs. These findings contribute to the paucity of knowledge by offering varied IBT strategies to support caregiving activities, which may be beneficial for other caregivers. Participants’ suggestions for IBT services can inform the development of new resources for OI caregivers and potentially for other caregivers of children living with rare conditions.
Reaching People With Disabilities in Underserved Areas Through Digital Interventions: Systematic Review (Preprint)
Authors: Zhou Leming , Parmanto Bambang
Published: October 2019

BACKGROUND

People with disabilities need rehabilitation interventions to improve their physical functioning, mental status, and quality of life. Many rehabilitation interventions can be delivered electronically ("digitally") via telehealth systems. For people with disabilities in underserved areas, electronically delivered rehabilitation interventions may be the only feasible service available for them.

OBJECTIVE

The objective of this study was to evaluate the current status of digital interventions for people with disabilities in remote and underserved areas.

METHODS

A systematic review was conducted on this topic. Keyword searches in multiple databases (PubMed, CINAHL, and Inspec) were performed to collect articles published in this field. The obtained articles were selected based on our selection criteria. Of the 198 identified articles, 16 duplicates were removed. After a review of the titles and abstracts of the remaining articles, 165 were determined to be irrelevant to this study and were therefore removed. The full texts of the remaining 17 articles were reviewed, and 6 of these articles were removed as being irrelevant to this study. The 11 articles remaining were discussed and summarized by 2 reviewers.

RESULTS

These 11 studies cover a few types of disabilities, such as developmental disabilities and mobility impairments as well as several types of disability-causing disorders such as stroke, multiple sclerosis, traumatic brain injury, and facio-scapulo-humeral muscular dystrophy. Most of these studies were small-scale case studies and relatively larger-scale cohort studies; the project evaluation methods were mainly pre-post comparison, questionnaires, and interviews. A few studies also performed objective assessment of functional improvement. The intervention technology was mainly videoconferencing. Moreover, 10 of these studies were for people with disabilities in rural areas and 1 was for people in urban communities.

CONCLUSIONS

A small number of small-scale studies have been conducted on digital interventions for people with disabilities in underserved areas. Although the results reported in these studies were mostly positive, they are not sufficient to prove the effectiveness of telehealth-based digital intervention in improving the situation among people with disabilities because of the small sample sizes and lack of randomized controlled trials.
Ambulatory Phonation Monitoring With Wireless Microphones Based on the Speech Energy Envelope: Algorithm Development and Validation (Preprint)
Authors: Wang Chi-Te , Han Ji-Yan , Fang Shih-Hau , Lai Ying-Hui
Published: October 2019

BACKGROUND

Voice disorders mainly result from chronic overuse or abuse, particularly in occupational voice users such as teachers. Previous studies proposed a contact microphone attached to the anterior neck for ambulatory voice monitoring; however, the inconvenience associated with taping and wiring, along with the lack of real-time processing, has limited its clinical application.

OBJECTIVE

This study aims to (1) propose an automatic speech detection system using wireless microphones for real-time ambulatory voice monitoring, (2) examine the detection accuracy under controlled environment and noisy conditions, and (3) report the results of the phonation ratio in practical scenarios.

METHODS

We designed an adaptive threshold function to detect the presence of speech based on the energy envelope. We invited 10 teachers to participate in this study and tested the performance of the proposed automatic speech detection system regarding detection accuracy and phonation ratio. Moreover, we investigated whether the unsupervised noise reduction algorithm (ie, log minimum mean square error) can overcome the influence of environmental noise in the proposed system.

RESULTS

The proposed system exhibited an average accuracy of speech detection of 89.9%, ranging from 81.0% (67,357/83,157 frames) to 95.0% (199,201/209,685 frames). Subsequent analyses revealed a phonation ratio between 44.0% (33,019/75,044 frames) and 78.0% (68,785/88,186 frames) during teaching sessions of 40-60 minutes; the durations of most of the phonation segments were less than 10 seconds. The presence of background noise reduced the accuracy of the automatic speech detection system, and an adjuvant noise reduction function could effectively improve the accuracy, especially under stable noise conditions.

CONCLUSIONS

This study demonstrated an average detection accuracy of 89.9% in the proposed automatic speech detection system with wireless microphones. The preliminary results for the phonation ratio were comparable to those of previous studies. Although the wireless microphones are susceptible to background noise, an additional noise reduction function can alleviate this limitation. These results indicate that the proposed system can be applied for ambulatory voice monitoring in occupational voice users.
How to put the burden from pollen allergy into numbers: Evaluation of ten years´ electronic generated symptom data from the PHD (Patient´s Hayfever Diary) in Austria and Germany (Preprint)
Authors: Bastl Katharina , Bastl Maximilian , Bergmann Karl-Christian , Berger Markus , Berger Uwe
Published: October 2019

BACKGROUND

Pollen allergies concern a significant proportion of the population globally. Today, online tools such as pollen diaries and mobile applications allow an easy and fast documentation of allergic symptoms via the internet.

OBJECTIVE

This study aimed to characterize the users of the Patient´s Hayfever Diary, to apply different symptom score calculations for comparison and to evaluate the contribution of organs and medication to the total score for the first time.

METHODS

Users of the Patient´s Hayfever Diary were filtered concerning their location (Austria/Germany), significant positive correlation to the respective pollen type (birch/grass) and at least 15 entries in the respective season. Four different symptom score calculation methods were applied to the datasets from 2009 until 2018, among them two raw symptom scores and two symptom load indices (normalized) calculations. Pearson correlation coefficients were calculated pairwise for four symptom score calculations.

RESULTS

Users are mostly male and in the age group of 21 to 40 years or in the group above 40 years. User numbers increased in the last years, especially when mobile applications were made available. The Pearson correlation coefficients show a significant linear relationship above 0.9 between the four symptom score datasets. The nose contributes the most to the symptom score and determines about 40% of the score.

CONCLUSIONS

The exact method of calculation of the symptom score is not critical. All computation methods show the same behavior (increase/decrease). The symptom load index is therefore a useful computation method in all fields exploring pollen allergy and online diaries are a globally applicable tool to monitor the effect of pollen on human health via electronic generated symptom data. However, studies should always consider the variation between different pollen seasons, years and biogeographical regions.
Inovasi Pendayagunaan Arsip Melalui Film Dokumenter sebagai Media Edukasi
Authors: Santosa Heri
Published: October 2019

Arsip merupakan sumber informasi yang dapat digunakan sebagai media pendidikan. Salah satu metode penyajian informasi arsip agar menjadi lebih menarik yaitu dengan cara dikemas menjadi sebuah film dokumenter. Menyajikan informasi arsip menjadi informasi yang lebih menarik merupakan tantangan bagi arsiparis. Penelitian ini memberikan gambaran bagaimana proses mengemas ulang informasi arsip menjadi sebuah film dokumenter. Metode yang digunakan dalam penelitian ini adalah studi kasus. Tujuan inovasi ini adalah menyajikan informasi arsip agar lebih menarik, lebih hidup, bisa digunakan untuk mendukung kebijakan-kebijakan yang diambil UGM, menyampaikan contoh serpihan sejarah tentang nilai-nilai ke UGM-an, sebagai pendidikan karakter bagi mahasiswa dan civitas akademika UGM, sebagai materi pembelajaran/media edukasi bagi mahasiswa UGM, mendokumentasikan dan menyelamatkan informasi arsip yang tersimpan di Arsip UGM maupun yang masih tersimpan di memori ingatan para tokoh-tokoh penting UGM sebagai pelaku sejarah yang masih hidup dengan cara diwawancarai sebagai narasumber sehingga semua informasi tersebut bisa bermanfaat bagi sivitas akademika UGM dan masyarakat pada umumnya. Kegiatan inovasi kemas ulang informasi arsip menjadi sebuah fim dokumenter merupakan cara yang efektif untuk sosialisasi dan penyebaran informasi kepada masyarakat luas.
Sensitivity and Specificity of Pathologic Findings to Diagnose Lupus Nephritis
Authors: Kudose Satoru , Santoriello Dominick , Bomback Andrew S. , Stokes M. Barry , D’Agati Vivette D. , Markowitz Glen S.
Published: October 2019

Background and objectives

In 2012, the Systemic Lupus International Collaborating Clinics proposed that lupus nephritis, in the presence of positive ANA or anti-dsDNA antibody, is sufficient to diagnose SLE. However, this “stand-alone” kidney biopsy criterion is problematic because the ISN/RPS classification does not specifically define lupus nephritis. We investigated the combination of pathologic features with optimal sensitivity and specificity for the diagnosis of lupus nephritis.

Design, setting, participants, & measurements

Three hundred consecutive biopsies with lupus nephritis and 560 contemporaneous biopsies with nonlupus glomerulopathies were compared. Lupus nephritis was diagnosed if there was a clinical diagnosis of SLE and kidney biopsy revealed findings compatible with lupus nephritis. The control group consisted of consecutives biopsies showing diverse glomerulopathies from patients without SLE, including IgA nephropathy, membranous glomerulopathy, pauci-immune glomerulonephritis, membranoproliferative glomerulonephritis (excluding C3 GN), and infection-related glomerulonephritis. Sensitivity and specificity of individual pathologic features and combinations of features were computed.

Results

Five characteristic features of lupus nephritis were identified: “full-house” staining by immunofluorescence, intense C1q staining, extraglomerular deposits, combined subendothelial and subepithelial deposits, and endothelial tubuloreticular inclusions, each with sensitivity ranging from 0.68 to 0.80 and specificity from 0.8 to 0.96. The presence of at least two, three, or four of the five criteria had a sensitivity of 0.92, 0.8, and 0.66 for the diagnosis of lupus nephritis, and a specificity of 0.89, 0.95, and 0.98.

Conclusions

In conclusion, combinations of pathologic features can distinguish lupus nephritis from nonlupus glomerulopathies with high specificity and varying sensitivity. Even with stringent criteria, however, rare examples of nonlupus glomerulopathies may exhibit characteristic features of lupus nephritis.
ANÁLISE ETNOBOTÂNICA DA ESTRUTURA DE QUINTAIS NA FRONTEIRA BRASIL/PARAGUAI
Authors: MAIA SEBASTIÃO GABRIEL CHAVES , SOBRINHO SEDERLI BOMBARDA
Published: October 2019

O presente estudo foi realizado no núcleo urbano do município de Ponta Porã-MS,” tendo como foco a estrutura do quintal, constituindo uma importante fonte de informações etnobotânicas, bem como as características socioculturais que constituem a população fronteiriça. As informações etnobotânicas foram obtidas por meio de observação participante e entrevista semiestruturada realizadas em 30 unidades domésticas devidamente acompanhadas de seus mantenedores. Os resultados obtidos foram constituídos com base nas informações qualiquantitativas, levando em consideração a forma de organização dos espaços, as espécies vegetais cultivadas nos quintais e as formas de usos, segundo a percepção dos moradores. No estudo foram identificadas 200 etnoespécies pertencentes a 65 famílias botânicas agrupadas em quatro estratos distintos: herbáceas, subarbustos, arbustos e arbóreas. Com tudo, observou-se que esses espaços além de serem considerados por muitos como extensão da residência são utilizados para finalidades distintas como: cultivos de diferentes categorias de plantas ornamentais, medicinais, alimentícias, criação de pequenos animais, lazer e de uso místico. Vale ressaltar ainda, a função social que os quintais desempenham promovendo a interação desses atores sociais, contribuindo na manutenção das relações socioculturais estabelecidas entre essa população, na conservação e, principalmente na transmissão desses conhecimentos ao longo das gerações.
Hacia una jurisprudencia de la vulnerabilidad: cuando los jubilados no pagan impuesto a las ganancias (En el centenario de la Constitución de Weimar de 1919)
Authors: Carnota Walter
Published: October 2019

Los grupos vulnerables que aparecen identificados en el plexo constitucional argentino a partir del artículo 75 inciso 23 de la Constitución Nacional han dado pie a una fértil elaboración jurisprudencial en materia de Seguridad Social, fundamentalmente en materia de reajustes de haberes previsionales y de impuesto a las ganancias, a través de sendos pronunciamientos liminares de la Corte Suprema de Justicia de la Nación.
Palabras Clave: Grupos vulnerable – Corte Suprema de Justicia de la Nación – Impuesto a las Ganancias – Exenciones
Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics
Authors: Todorovic Lidija , Mandusic Vesna , Vucetic-Tadic Biljana , Zivaljevic Vladan , Paunovic Ivan , Stanojevic Boban
Published: October 2019

A growing number of studies suggest a tumor suppressive role and potential prognostic significance of miR- 30a-3p in different types of cancer. However, relatively few studies have focused on this microRNA in neoplastic thyroid lesions, including papillary thyroid cancer (PTC). The aim of our study was to shed more light on the potential involvement and clinical relevance of miR-30a-3p in this type of cancer. We examined the expression levels of this microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using quantitative RT-PCR. We analyzed their association with clinical and histopathological parameters. The results revealed that miR-30a-3p was significantly downregulated in the majority of PTC tissues compared to corresponding non-tumor tissues. Moreover, decreased expression of miR-30a-3p was associated with advanced clinical stage, presence of multiple tumor foci and capsular invasion, suggesting a role in aggressive disease. Although the role of this microRNA and its prognostic utility remain to be elucidated, the presented data suggest that downregulated expression of miR-30a-3p indicates poorer prognosis in PTC patients, warranting further investigations.