bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Dietary Supplementation with Tea Residue on Growth Performance, Digestibility, and Diarrhea in Piglets
Authors: Wang Chunfeng , Zhong Yan , Liu Han , Wang Hanmin , Li Yali , Wang Qiye , Li Jianzhong , Huang Pengfei , Yang Huansheng
Published: February 2024

Thirty-six healthy 21-day-old weaned ternary piglets (Duroc × Landrace × Yorkshire) were randomly divided into two treatments with 18 replicates per treatment and one pig per replicate. The control group was fed with a basal diet and the test group was fed with diets supplemented with 1 kg/t tea residue. The test period was 28 days. The results are as follows: The addition of tea residue in the diet had no significant effect on the growth performance of weaned piglets (p > 0.05), but it could significantly reduce the diarrhea rate of piglets from 1 to 7 days and 1 to 28 days (p < 0.05). Compared with the control group, the dietary supplementation of tea residue had no significant effect on nutrient apparent digestibility, plasma biochemical indexes and plasma immune indexes (p > 0.05) but increased the content of glutathione in plasma (p < 0.05). Tea residue had no significant effect on the morphology of the jejunum and ileum of piglets (p > 0.05), but it could significantly reduce the content of chloride ions in feces (p < 0.05). Compared with the basal diet group, there was no significant difference in the relative expression of TMEM16A and CFTR mRNA in the colon of weaned piglets (p > 0.05). The whole-cell patch clamp recording showed that the TMEM16A and CFTR ion channels could be activated by ionomycin and forskolin, respectively. However, when HT-29 cells transfected with TMEM16A and CFTR channels were treated with tea residue extract, it could significantly inhibit the chloride current of the TMEM16A and CFTR ion channels (p < 0.05).
Antioxidant and Anticancer Activity of Pericarp Water Extracts of Mediterranean Ancient Chestnut Accessions
Authors: Spissu Ylenia , Molinu Maria Giovanna , D’hallewin Guy , Sanna Giulia , Serra Gavina Rita , Muroni Antonella , Barberis Antonio
Published: February 2024

The residue of chestnut processing generates a large amount of waste material, a resource not adequately exploited. The antioxidant and antitumoral properties of cold and hot water extracts from discarded pericarp of four chestnut Sardinian accessions and one marron variety were studied. The antioxidant capacity of the extracts was determined by spectrophotometric and electrochemical tests. The 1,1-diphenyl-2-pic-rylhydrazyl (DPPH) and 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) results were highly correlated with each other; likewise, a good correlation was found between Ferric Reducing Antioxidant Power (FRAP) and cyclic voltammetry (CV) values, both based on the direct transfer of electrons. The antiproliferative effect on normal cells (fibroblasts), and on colon (RKO and SW48) and breast (MCF7) cancer cells was evaluated. Additionally, this paper marks the first application of chestnut extracts to investigate their effects on melanoma (B16F10) cells. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test demonstrated that temperature and different extraction times significantly influenced the growth of cells, both normal and tumor. The fibroblast growth was significantly inhibited by moderate doses of cold extracts, while the GI50 values calculated for hot extracts were high, regardless of the accession or cultivar. An even more marked inhibitory action of the cold extracts was observed both on the growth of RKO and SW48 cells and on B16F10 melanoma cells. Otherwise, an extract concentration, both cold and hot, of no less than 243 µg mL−1 is required to achieve a 50% inhibition of MCF7 cell growth.
Influence of the Slope and Gate Offset on Movement Variability and Performance in Slalom Skiing
Authors: Pérez-Chirinos Buxadé Carla , Moras Feliu Gerard , Tuyà Viñas Sílvia , Trabucchi Michela , Gavaldà Castet Dani , Padullés Riu Josep Maria , Fernández-Valdés Villa Bruno
Published: February 2024

Adaptability to all types of terrain changes, slopes, and course settings is a key aspect related to the coordinative ability that elite skiers possess. In recent years, several studies have analyzed coordinative aspects of different motor actions via the assessment of movement variability (MV), an indicator of the motor control that assesses movement regularity. The aims of this study were (a) to evaluate the influence of different slopes and slalom (SL) gate offsets on MV and performance and (b) to assess the relationship between MV and performance. Four SL courses were set: a flat-turned (FT), a steep-turned (ST), a flat-straighter (FS), and a steep-straighter (SS). Five elite alpine skiers (21.2 ± 3.3 years, 180.2 ± 5.6 cm, 72.8 ± 6.6 kg) completed several runs at maximum speed for each SL course. A total of 77 runs were obtained. The use of an IMU accelerometer attached to the lower back of skiers measured MV through entropy. The skiers’ performance was evaluated with the total time of each run. The one-way repeated measures analysis revealed that the steepness of the slope significantly increases skiers’ MV, concretely between FS and ST courses (p = 0.004). Differences at the 10% level have been found between FS and SS and FT and ST courses (p= 0.055 and p = 0.078, respectively). For a given slope, turned courses (FT and ST) tend to produce a higher MV. In addition, faster times correlate with lower MV (r = 0.587, p = 0.01). It has been observed that both steeper and turned courses produce greater MV and that the best performing skiers have lower MV. Determining MV through entropy can be used to assess skiers’ expertise regarding different types of slopes and gate offsets.
Research on the Application of THz-TDS in Coal–Rock Interface Recognition
Authors: Jiang Zichao , Meng Tianhua , Yang Chunhua , Huang Lei , Liu Hongmei , Hu Weidong
Published: February 2024

The recognition of coal–rock interface is very crucial for research in the intelligent production of coal mines. To this end, the study investigated the application of terahertz time-domain spectroscopy in the recognition of coal–rock interface, including the identification of coal–rock and coal–rock mixtures, as well as the accurate characterization of coal seam thickness. Terahertz detection was used to obtain the optical parameter information of pressed pellets prepared by mixing two different kinds of coal and two kinds of rock. Based on the experiment’s results, a database was established for the identification of coal–rock interfaces for coal mining machines. The terahertz detection was performed on 10 different kinds of sheet anthracite with different thicknesses, and the terahertz spectra of coal seams with different thicknesses were simulated and calculated using simulation software. By comparing the two effective mining thicknesses, parameters can be provided for coal seam mining. The experiment and simulation show that the terahertz time-domain spectroscopy technology has a promising application prospect in the identification of coal–rock interface.
A Secured Intrusion Detection System for Mobile Edge Computing
Authors: Alsubhi Khalid
Published: February 2024

With the proliferation of mobile devices and the increasing demand for low-latency and high-throughput applications, mobile edge computing (MEC) has emerged as a promising paradigm to offload computational tasks to the network edge. However, the dynamic and resource-constrained nature of MEC environments introduces new challenges, particularly in the realm of security. In this context, intrusion detection becomes crucial to safeguard the integrity and confidentiality of sensitive data processed at the edge. This paper presents a novel Secured Edge Computing Intrusion Detection System (SEC-IDS) tailored for MEC environments. The proposed SEC-IDS framework integrates both signature-based and anomaly-based detection mechanisms to enhance the accuracy and adaptability of intrusion detection. Leveraging edge computing resources, the framework distributes detection tasks closer to the data source, thereby reducing latency and improving real-time responsiveness. To validate the effectiveness of the proposed SEC-IDS framework, extensive experiments were conducted in a simulated MEC environment. The results demonstrate superior detection rates compared to traditional centralized approaches, highlighting the efficiency and scalability of the proposed solution. Furthermore, the framework exhibits resilience to resource constraints commonly encountered in edge computing environments.
Assessment and Review of Heavy Metals Pollution in Sediments of the Mediterranean Sea
Authors: Robledo Ardila Pedro Agustín , Álvarez-Alonso Rebeca , Árcega-Cabrera Flor , Durán Valsero Juan José , Morales García Raquel , Lamas-Cosío Elizabeth , Oceguera-Vargas Ismael , DelValls Angel
Published: February 2024

The impact of marine sediment pollution is crucial for the health of the seas, particularly in densely populated coastal areas worldwide. This study assesses the concentration and distribution of heavy metals in the marine sediments of the main regions of the Mediterranean Sea. The results underscore high concentrations of mercury (Hg), nickel (Ni), and copper (Cu), whereas chromium (Cr), zinc (Zn), cadmium (Cd), barium (Ba), and vanadium (V) exhibit moderate values. To assess the heavy metal results, sediment quality guidelines and pollution indices (Igeo and Geochemical Signal Type-GST) were employed, revealing a consistent trend of decreasing concentrations from the coastal zone to the open sea. Principal Component Analysis (PCA) emphasizes the significant roles of Cu, Zn, Ba, and Cr in sediment chemistry. The study suggests that the distribution patterns of heavy metals are linked to wastewater discharges in coastal areas, requiring effective management strategies to ensure the health of the Mediterranean Sea.
Mechanism of Stratum Instability and Dynamic Deformation under Discontinuous Boundary Conditions
Authors: Guo Hanxiao , Yu Weijian , Wu Genshui , Li Ke , Liao Ze
Published: February 2024

A fault disrupts the continuity of the rock strata in a mining area. To study the law governing the fracture of overlying strata in mining areas under discontinuous boundary conditions, the overlying strata were redefined and grouped based on the activity characteristics of each rock layer during the overall movement of the overlying strata. The activity patterns of different layers of the fault were obtained through the movement and failure forms of each group of rock layers. The relationship among the size of the coal pillar at the boundary of the fault, the dip angle of the fault, and the movement angle of the rock strata was considered. A model of the spatial relationship between the overlying rock movement zone of the quarry and the fault surface was established. The limit equilibrium equations of the key layer in the fault zone before breaking were established based on the tensile strength of the rock layer. In addition, the mechanical slip instability criterion and the deflection instability criterion of the discontinuous-boundary rock mass are given herein. Based on a field case, a double criterion was used to determine the initiating activated rock layers of the fault in the cases where the fault dip was smaller than the rock movement angle. Rock movement during excavation was simulated by similar simulation tests, and different levels of rock movement patterns in the boundary fault zone were focused on monitoring and analyzing. The stress and displacement changes in different rock layers in the fault zone were analyzed with numerical simulation results. The results show the following: if the dip angle of the fault is smaller than the movement angle of the rock layer, the delamination space of the fault surface is mainly distributed in the bending and sinking zone of the overlying rock; with an increase in the working-face advancement distance, the vertical pressure of the upper part of the fault gradually decreases, and the stress-concentration area in the middle and lower part of the fault gradually increases; the rock layer of the upper part of the fault, which is mainly composed of the key stratum, is the main area of activation of the fault.
Phantomless Computed Tomography-Based Quantitative Bone Mineral Density Assessment: A Literature Review
Authors: Mallio Carlo A. , Vertulli Daniele , Bernetti Caterina , Stiffi Massimo , Greco Federico , Van Goethem Johan , Parizel Paul M. , Quattrocchi Carlo C. , Beomonte Zobel Bruno
Published: February 2024

The global surge in aging populations has intensified osteoporosis challenges, necessitating improved diagnostic methods. While dual X-ray absorptiometry (DXA) is the conventional standard in assessing bone mineral density (BMD), the exploration of quantitative computed tomography (QCT) has been proposed, particularly phantomless techniques. Challenges in single-energy CT, emphasizing internal calibration standards like subcutaneous fat, are discussed. Advances in PL-QCT, notably with automatic region of interest (ROI) selection, show improved accuracy. Dual-energy CT (DECT) introduces new dimensions for musculoskeletal analysis. Despite advancements, challenges persist, including interindividual variability and patient-specific factors. Evolving single-energy CT and DECT techniques show promise in refining BMD assessment and osteoporosis diagnosis, enhancing patient care. Continued research and integration into clinical practice are vital for realizing these advancements’ full benefits. In this review, we evaluate and summarize current evidence on the feasibility and different approaches to achieve analysis of BMD with phantomless QCT.
Accessing Near-Field Strong Ground Motions Using a Multi-Scheme Method in the Kalawenguquan Fault, Xinjiang, China
Authors: Li Jiangyi , Zhou Bengang , He Zhongtai , Ji Haomin , Wang Lei , Bao Guodong
Published: February 2024

The middle segment of the Kalawenguquan fault has been active since the Holocene, with a maximum credible earthquake magnitude of MS 7.5. We established two source models based on empirical relationships, as well as geological, geomorphological, and seismic characteristics. Taking into account the uncertainties of simulation parameters, we adopted the stochastic finite-fault method to calculate all combinations of a multi-scheme simulation. The effects of different source models, initial rupture points, and site locations on the prediction of ground motion parameters were analyzed. The results indicate that when a site is located on a smaller asperity and is a certain distance from the largest asperity, the simulation results are higher. For different sites, when the initial rupture point is located near the smaller rather than the larger asperity, the acceleration response spectra are higher. Our results show that the relationships between the initial rupture points, asperities, and sites have a significant impact on the simulation results. Therefore, our study highlights the relevance of determining the initial rupture point and source model to obtain a reasonable evaluation for near-field strong ground motion simulations at major infrastructures.
Administering Nitric Oxide (NO) with High Flow Nasal Cannulas: A Simple Method
Authors: Cousin Vladimir L. , Joye Raphael , Polito Angelo
Published: February 2024

Inhaled nitric oxide (iNO) is a pulmonary vasodilator that plays an important clinical ICU role. The administration of iNO is usually performed through an endotracheal tube, but spontaneously breathing patients might also benefit from iNO administration. The use of the non-invasive administration of iNO through high-flow nasal cannula (HFNC) allows for NO delivery in spontaneously breathing patients who still need supplemental oxygen and positive airway pressure. A simple method to administer NO through HFNC is described here using standard commercially available NO administration and HFNC.
Salt Lake Aerosol Overview: Emissions, Chemical Composition and Health Impacts under the Changing Climate
Authors: Abbas Muhammad Subtain , Yang Yajuan , Zhang Quanxi , Guo Donggang , Godoi Ana Flavia Locateli , Godoi Ricardo Henrique Moreton , Geng Hong
Published: February 2024

Salt Lakes, having a salt concentration higher than that of seawater and hosting unique extremophiles, are predominantly located in drought-prone zones worldwide, accumulating diverse salts and continuously emitting salt dust or aerosols. However, knowledge on emission, chemical composition, and health impacts of Salt Lake aerosols under climate change is scarce. This review delves into the intricate dynamics of Salt Lake aerosols in the context of climate change, pointing out that, as global warming develops and weather patterns shift, Salt Lakes undergo notable changes in water levels, salinity, and overall hydrological balance, leading to a significant alteration of Salt Lake aerosols in generation and emission patterns, physicochemical characteristics, and transportation. Linked to rising temperatures and intensified evaporation, a marked increase will occur in aerosol emissions from breaking waves on the Salt Lake surface and in saline dust emission from dry lakebeds. The hygroscopic nature of these aerosols, coupled with the emission of sulfate aerosols, will impart light-scattering properties and a cooling effect. The rising temperature and wind speed; increase in extreme weather in regard to the number of events; and blooms of aquatic microorganisms, phytoplankton, and artemia salina in and around Salt Lakes, will lead to the release of more organic substances or biogenic compounds, which contribute to the alteration of saline aerosols in regard to their quantitative and chemical composition. Although the inhalation of saline aerosols from Salt Lakes and fine salt particles suspended in the air due to salt dust storms raises potential health concerns, particularly causing respiratory and cardiovascular disease and leading to eye and skin discomfort, rock salt aerosol therapy is proved to be a good treatment and rehabilitation method for the prevention and treatment of pneumoconiosis and chronic obstructive pulmonary disease (COPD). It is implied that the Salt Lake aerosols, at a certain exposure concentration, likely can delay the pathogenesis of silicosis by regulating oxidative stress and reducing interstitial fibrosis of the lungs. It emphasizes the interconnectedness of climate changes, chemical composition, and health aspects, advocating for a comprehensive and practical approach to address the challenges faced by Salt Lake aerosols in an ever-changing global climate.
Robustness Analysis for Sundry Disturbed Open Loop Dynamics Using Robust Right Coprime Factorization
Authors: Xu Yuanhong , Deng Mingcong
Published: February 2024

In this paper, the robustness of a system with sundry disturbed open loop dynamics is investigated by employing robust right coprime factorization (RRCF). These sundry disturbed open loop dynamics are present not only in the feed forward path, but also within the feedback loop. In such a control framework, the nominal plant is firstly right coprime factorized and a feed forward and a feedback controllers are designed based on Bezout identity to ensure the overall stability. Subsequently, considering the sundry disturbed open loop dynamics, a new condition formulated as a disturbed Bezout identity is put forward to achieve the closed loop stability of the system, even in the presence of disturbances existing in sundry open loops, where in the feedback loop a disturbed identity operator is defined. This approach guarantees the system robustness if a specific inequality condition is satisfied. And, it should be noted that the proposed approach is applicable to both linear and nonlinear systems with sundry disturbed open loop dynamics. Simulations demonstrate the effectiveness of our methodology.
Genetic and Epigenetic Aspects of Type 1 Diabetes Mellitus: Modern View on the Problem
Authors: Minniakhmetov Ildar , Yalaev Bulat , Khusainova Rita , Bondarenko Ekaterina , Melnichenko Galina , Dedov Ivan , Mokrysheva Natalia
Published: February 2024

Omics technologies accumulated an enormous amount of data that advanced knowledge about the molecular pathogenesis of type 1 diabetes mellitus and identified a number of fundamental problems focused on the transition to personalized diabetology in the future. Among them, the most significant are the following: (1) clinical and genetic heterogeneity of type 1 diabetes mellitus; (2) the prognostic significance of DNA markers beyond the HLA genes; (3) assessment of the contribution of a large number of DNA markers to the polygenic risk of disease progress; (4) the existence of ethnic population differences in the distribution of frequencies of risk alleles and genotypes; (5) the infancy of epigenetic research into type 1 diabetes mellitus. Disclosure of these issues is one of the priorities of fundamental diabetology and practical healthcare. The purpose of this review is the systemization of the results of modern molecular genetic, transcriptomic, and epigenetic investigations of type 1 diabetes mellitus in general, as well as its individual forms. The paper summarizes data on the role of risk HLA haplotypes and a number of other candidate genes and loci, identified through genome-wide association studies, in the development of this disease and in alterations in T cell signaling. In addition, this review assesses the contribution of differential DNA methylation and the role of microRNAs in the formation of the molecular pathogenesis of type 1 diabetes mellitus, as well as discusses the most currently central trends in the context of early diagnosis of type 1 diabetes mellitus.
Adverse Events of Cabozantinib as a Potential Prognostic Factor in Metastatic Renal Cell Carcinoma Patients: Real-World Experience in a Single-Center Retrospective Study
Authors: Domański Piotr , Piętak Mateusz , Kruczyk Barbara , Jarosińska Jadwiga , Mydlak Anna , Demkow Tomasz , Darewicz Marta , Sikora-Kupis Bożena , Dumnicka Paulina , Kamzol Wojciech , Kucharz Jakub
Published: February 2024

Cabozantinib, an oral inhibitor targeting MET, AXL, and VEGF receptors, has become a key component of a sequential treatment strategy for clear cell renal cell carcinoma (ccRCC). The purpose of this work is to show that effective management of adverse events (AEs) during cabozantinib treatment and achieving a balance between AEs and treatment efficacy is crucial to achieving therapeutic goals. In this retrospective study, involving seventy-one metastatic RCC (mRCC) patients receiving second or subsequent lines of cabozantinib at the Department of Genitourinary Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, we explored the impact of AEs on overall survival (OS) and progression-free survival (PFS). AEs were observed in 92% of patients. Hypothyroidism during treatment was significantly associated with prolonged OS and PFS (HR: 0.31; p < 0.001 and HR: 0.34; p < 0.001, respectively). The occurrence of hand–foot syndrome (HFS) was also linked to improved OS (HR: 0.46; p = 0.021). Patients experiencing multiple AEs demonstrated superior OS and PFS compared to those with one or no AEs (HR: 0.36; p < 0.001 and HR: 0.30; p < 0.001, respectively). Hypothyroidism and HFS serve as valuable predictive factors during cabozantinib treatment in ccRCC patients, indicating a more favorable prognosis.
Exploring the Acquisition of Social Communication Skills in Children with Autism: Preliminary Findings from Applied Behavior Analysis (ABA), Parent Training, and Video Modeling
Authors: Bordini Daniela , Moya Ana Cláudia , Asevedo Graccielle Rodrigues da Cunha , Paula Cristiane Silvestre , Brunoni Décio , Brentani Helena , Caetano Sheila Cavalcante , Mari Jair de Jesus , Bagaiolo Leila
Published: February 2024

Social communication skills, especially eye contact and joint attention, are frequently impaired in autism spectrum disorder (ASD) and predict functional outcomes. Applied behavior analysis is one of the most common evidence-based treatments for ASD, but it is not accessible to most families in low- and middle-income countries (LMICs) as it is an expensive and intensive treatment and needs to be delivered by highly specialized professionals. Parental training has emerged as an effective alternative. This is an exploratory study to assess a parental intervention group via video modeling to acquire eye contact and joint attention. Four graded measures of eye contact and joint attention (full physical prompt, partial physical prompt, gestural prompt, and independent) were assessed in 34 children with ASD and intellectual disability (ID). There was a progressive reduction in the level of prompting required over time to acquire eye contact and joint attention, as well as a positive correlation between the time of exposure to the intervention and the acquisition of abilities. This kind of parent training using video modeling to teach eye contact and joint attention skills to children with ASD and ID is a low-cost intervention that can be applied in low-resource settings.
The Difficulties in Interpersonal Regulation of Emotions Scale (DIRE): Factor Structure and Measurement Invariance across Gender and Two Chinese Youth Samples
Authors: Zhao Yanhua H. , Wang Lili , Zhang Yuan , Niu Jiahui , Liao Min , Zhang Lei
Published: February 2024

Effective interpersonal emotion regulation (IER) strategies have been found to be meaningful predictors for positive psychological functioning. The Difficulties in Interpersonal Regulation of Emotions Scale (DIRE) is a measure developed to assess maladaptive IER strategies. This study aimed to examine the psychometric properties of the Chinese version of DIRE using two college student samples (Sample 1: n = 296; Sample 2: n = 419). The two-factor structure of DIRE (venting and excessive reassurance-seeking) was confirmed through an exploratory structure equation modeling approach. Our results demonstrated that the Chinese version of DIRE exhibits a similar factor structure (in both samples) as the original DIRE. Measurement invariance across gender and samples was also achieved. Latent mean analyses demonstrated that females more frequently reported excessive reassurance-seeking (in both samples) and venting (in Sample 1) than males. Furthermore, venting and excessive reassurance-seeking were significantly related to intrapersonal emotion regulation and well-being indicators. Although in Chinese culture DIRE performs somewhat differently from the original DIRE, the current findings suggest that DIRE is a reliable and valid scale with which to measure the IER strategies in Chinese culture and the use of this measure in clinical practice may allow for an accurate assessment of emotion regulation deficits in clients from other diverse cultures.
Minimizing Cost Overrun in Rail Projects through 5D-BIM: A Conceptual Governance Framework
Authors: Hussain Osama A. I. , Moehler Robert C. , Walsh Stuart D. C. , Ahiaga-Dagbui Dominic D.
Published: February 2024

Integration of 5D Building Information Modeling (BIM) into large rail projects has the potential to significantly enhance cost management and control. Nevertheless, 5D-BIM implementation has encountered difficulties stemming from technical, functional, and governance-related factors. This paper builds a conceptual framework to support financial decision making, enhances project management, and promotes efficient project delivery. The framework encompasses a set of interrelated elements that include project governance, BIM policies and standards, digital platforms, BIM LOD, cost-estimation classification, and continuous improvement. The proposed framework acknowledges the significance of project governance in guiding and organizing the implementation of 5D-BIM. Additionally, BIM policies and standards ensure the adherence to quality standards for the produced BIM models. Digital platforms serve as the basis for multiple users to generate, access, share, and exchange project information. BIM LOD promotes collaboration and coordination among all project stakeholders. Cost-estimation classification aligns the estimation process with the development of project scope and financial decision making. Continuous improvement plays a vital role in optimizing processes, enhancing efficiency, and achieving higher-quality outcomes. Moreover, it fosters stakeholder satisfaction, improves project performance, and nurtures a conducive environment for innovation and learning. The study analyzes the framework utilization in Victorian rail projects and identifies key implementation challenges. The main technical hurdles encountered were the lack of current horizontal infrastructure standards for data exchange and the lack of compatibility with current cost-management standards. Increased project complexity and the absence of clear project governance strategies and processes also posed organizational challenges. A further validation of the framework in real-world rail projects was recommended to achieve the implementation goals.
Design and Hysteretic Performance Analysis of a Novel Multi-Layer Self-Centering Damper with Shape Memory Alloy
Authors: Zhang Hua , Zhao Lu , Li Anbang , Xu Shanhua
Published: February 2024

This paper presented the development process of a novel multi-layer self-centering damper utilizing a NiTi shape memory alloy (SMA) with remarkable superelastic properties. The construction and operating principles of the novel damping device were introduced. A model for calculating the restoring force–displacement hysteretic curve of the novel damper was established, and based on this theoretical model, a parameter analysis of the damper’s hysteresis performance was conducted. The effect of SMA pre-strain, SMA diameter, number of layers in the damper, and number of SMA wires per layer on the damper’s stiffness, the unit cycle energy dissipation, and the equivalent viscous damping ratio were investigated, respectively. The results showed that the restoring force–displacement hysteretic curve of the novel SMA damper exhibits a full spindle shape, demonstrating the damper’s excellent energy dissipation capacity, self-centering capability, significant stroke, and unique variable stiffness characteristics (i.e., appropriate initial stiffness, minimal isolation stiffness, and significant limit stiffness). The results also indicated that the SMA pre-strain has a minor impact on the damper’s stiffness but a significant influence on unit cyclic energy dissipation and equivalent damping ratio. As the SMA pre-strain increased from 0.03 to 0.04, 0.05, and 0.06, the maximum stroke of the damper continuously decreases, while the unit cyclic energy dissipation initially increases and then decreases, with the optimal energy dissipation achieved at a pre-strain of 0.04. Increasing the SMA diameter results in a higher damper stiffness and energy dissipation capacity, with no significant change in maximum stroke and equivalent damping ratio. Increasing the number of damper layers leads to an increase in maximum stroke and unit-cycle energy dissipation, accompanied by a decrease in stiffness and almost constant equivalent damping ratio. As the number of SMA wires per layer increased from 8 to 16 and 32, the maximum stroke and equivalent damping ratio presented little variation, but the damper’s stiffness and unit cyclic energy dissipation continuously increased.
Induced Partial Saturation Using Pseudomonas stutzeri Biogas for Mitigate Structure Settlement
Authors: Lv Meitong , Zhang Dingwen , Peng Erxing , Guo Yinhe
Published: February 2024

Induced partial saturation (IPS) is a new foundation treatment method for mitigating soil liquefaction using biogas. A series of laboratory tests were performed to demonstrate the influencing factors of IPS using Pseudomonas stutzeri biogas. On the basis of the optimal biogas production conditions, the intervention effect of Pseudomonas stutzeri biogas on the foundation deformation under buildings was investigated based on shaking table tests. The test results showed that the best carbon source in the denitrification process of Pseudomonas stutzeri biogas is sodium citrate. The most effective initial value of optical density-based concentration was 0.1. The carbon–nitrogen ratio (C/N) of the bacterium suspension was used as the index to control the saturation. The degree of saturation reduction showed a good linear correlation with the C/N. The optimum temperature of this method was between 20 °C and 30 °C. The most suitable pH value was between 7 and 9. The environmental factors had minimal influence on the degree of saturation reduction but had a significant effect on the average rate of gas generation and the period of initial stagnation. After Pseudomonas stutzeri biogas desaturation, the settlement of the building was greatly reduced. The settlement of saturation of 92.5% sand foundation reached 17.1 mm, and the 85% saturation was only 10.6 mm. These results provide a good foundation for the feasibility of utilizing Pseudomonas stutzeri biogas mitigation of the liquefaction hazard of sand.
Statistical Analysis of Lean Construction Barriers to Optimize Its Implementation Using PLS-SEM and PCA
Authors: Romo Rubén , Alejo-Reyes Avelina , Orozco Francisco
Published: February 2024

The construction industry performs many tasks scheduled and related to other activities. Companies must optimize their operations, increase efficiency, eliminate waste, and deliver better products to their customers. As a result, this study aims to identify the main challenges associated with the implementation of the Lean Construction model in small and medium-sized construction companies and optimize the implementation of this process using statistically-focused mathematical models. This study was conducted using the partial least squares (PLS-SEM) method and also carried out the principal component analysis to optimize Lean barriers so that they can be properly implemented in the construction industry. The most important obstacles are displayed, as well as the relationships with other factors. Significant relationships have been discovered between the barriers to Lean construction adoption, especially with regard to corporate culture, communication, training, leadership, and the influence of mentality on business and employee adaptability. Construction executives and managers can make well-informed policy and strategic decisions by having a thorough understanding of the main barriers to Lean implementation. This information enables them to focus on the implementation of Lean technologies in projects, to increase market competitiveness, reduce waste and enhance overall work efficiency.
Identification of Safety Risk Factors in Metro Shield Construction
Authors: Tang Chao , Shen Chuxiong , Zhang Jiaji , Guo Zeng
Published: February 2024

Among the construction methods for subway projects, shield method construction technology has become a more widely used construction method for urban subway construction due to the advantages of a high degree of construction mechanization, low impact of the construction process on the environment, and strong adaptability of the shield machine to the stratum, etc. However, because of the complexity of the surrounding buildings (structures) in the subway construction, coupled with the diversity of the subway shield method construction activities and the uncertainties in the construction environment, to a certain extent, it is determined that the subway construction process is very complicated. The purpose of this study is based on the text mining method, where text is mined and utilized to realize the identification, extraction, and display of safety risk factors. Thus, it guides the safety management on site and provides a basis for knowledge reuse in other metro shield construction projects. Firstly, we analyze the shortcomings of safety risk management in domestic and international metro shield construction via a literature review, especially the utilization of safety risk text data. Secondly, we collect the risk reports submitted by all parties via the “Metro Project Safety Risk Early Warning System”, and manually screen the hidden danger statements with risk characterization to establish a corpus. Thirdly, we use the Jieba word separation package to extract and display the safety risk factors, so as to guide the on-site safety management. Subsequently, with the help of the Jieba word segmentation package for Chinese word segmentation, we develop a professional thesaurus to improve the effect of word segmentation; then, we use the TF-IDF parameter assignment to achieve the structural transformation of the text to extract high-frequency vocabulary; finally, from the high-frequency vocabulary to screen words containing the semantics of the risk to establish the risk of an initial set of words, we use the existing standards and norms to form the collection of safety risk factors of subway shield construction and generate the cloud diagram for visual display.
Pristine and Coated Carbon Nanotube Sheets—Characterization and Potential Applications
Authors: Giri Prakash , Gill Irwin , Swensgard Morgan , Kaiser Alexandra , Rust Audrey , Stuparyk Brian , Fisher Andrew , Williams Justice , Renoit Katie , Kreeb Eleanor , Lavenan Corentin , Schulz Mark J.
Published: February 2024

A carbon nanotube (CNT) sheet is a nonwoven fabric that is being evaluated for use in different textile applications. Several properties of pristine CNT sheets and CNT sheets coated with a polysilazane sealant and coating were measured and compared in the paper. The polysilazane coating is used to reduce the shedding of CNT fibers from the sheet when the sheet is in contact with surfaces. Most fabrics show some shedding of fibers during the washing or abrasion of the fabric. This study showed that the coating reduces the shedding of fibers from CNT fabric. The coating also increased the flame resistance of the fabric. The pristine and coated sheets both have low strength but high strain to failure. The pristine and coated CNT sheet densities are 0.48 g/cc and 0.65 g/cc, respectively. The pristine CNT sheet is approximately 27 μ thick. The coated sheet is approximately 24 μ thick. The coating may have densified the sheet, making it thinner. The thickness of the compliant sheets was difficult to measure and is a source of error in the properties. Characterization results are given in this paper. The results are for comparison purposes and not to establish material properties data. Possible applications for CNT sheets are briefly discussed.
Transcriptomic Profiling for Prognostic Biomarkers in Early-Stage Squamous Cell Lung Cancer (SqCLC)
Authors: Šutić Maja , Dmitrović Branko , Jakovčević Antonia , Džubur Feđa , Oršolić Nada , Debeljak Željko , Försti Asta , Seiwerth Sven , Brčić Luka , Madzarac Goran , Samaržija Miroslav , Jakopović Marko , Knežević Jelena
Published: February 2024

Squamous cell lung carcinoma (SqCLC) is associated with high mortality and limited treatment options. Identification of therapeutic targets and prognostic biomarkers is still lacking. This research aims to analyze the transcriptomic profile of SqCLC samples and identify the key genes associated with tumorigenesis, overall survival (OS), and a profile of the tumor-infiltrating immune cells. Differential gene expression analysis, pathway enrichment analysis, and Gene Ontology analysis on RNA-seq data obtained from FFPE tumor samples (N = 23) and healthy tissues (N = 3) were performed (experimental cohort). Validation of the results was conducted on publicly available gene expression data using TCGA LUSC (N = 225) and GTEx healthy donors’ cohorts (N = 288). We identified 1133 upregulated and 644 downregulated genes, common for both cohorts. The most prominent upregulated genes were involved in cell cycle and proliferation regulation pathways (MAGEA9B, MAGED4, KRT, MMT11/13), while downregulated genes predominately belonged to immune-related pathways (DEFA1B, DEFA1, DEFA3). Results of the survival analysis, conducted on the validation cohort and commonly deregulated genes, indicated that overexpression of HOXC4 (p < 0.001), LLGL1 (p = 0.0015), and SLC4A3 (p = 0.0034) is associated with worse OS in early-stage SqCLC patients. In contrast, overexpression of GSTZ1 (p = 0.0029) and LILRA5 (p = 0.0086) was protective, i.e., associated with better OS. By applying a single-sample gene-set enrichment analysis (ssGSEA), we identified four distinct immune subtypes. Immune cell distribution suggests that the memory T cells (central and effector) and follicular helper T cells could serve as important stratification parameters.
A Potential Prognostic Gene Signature Associated with p53-Dependent NTRK1 Activation and Increased Survival of Neuroblastoma Patients
Authors: Currie David , Wong Nicole , Zane Isabelle , Rix Tom , Vardakastanis Marios , Claxton Amelia , Ong Karine K. V. , Macmorland William , Poivet Arthur , Brooks Anthony , Niola Paola , Huntley Derek , Montano Ximena
Published: February 2024

Neuroblastoma is the most common extracranial solid tumour in children, comprising close to 10% of childhood cancer-related deaths. We have demonstrated that activation of NTRK1 by TP53 repression of PTPN6 expression is significantly associated with favourable survival in neuroblastoma. The molecular mechanisms by which this activation elicits cell molecular changes need to be determined. This is critical to identify dependable biomarkers for the early detection and prognosis of tumours, and for the development of personalised treatment. In this investigation we have identified and validated a gene signature for the prognosis of neuroblastoma using genes differentially expressed upon activation of the NTRK1-PTPN6-TP53 module. A random survival forest model was used to construct a gene signature, which was then assessed across validation datasets using Kaplan–Meier analysis and ROC curves. The analysis demonstrated that high BASP1, CD9, DLG2, FNBP1, FRMD3, IL11RA, ISGF10, IQCE, KCNQ3, and TOX2, and low BSG/CD147, CCDC125, GABRB3, GNB2L1/RACK1 HAPLN4, HEBP2, and HSD17B12 expression was significantly associated with favourable patient event-free survival (EFS). The gene signature was associated with favourable tumour histology and NTRK1-PTPN6-TP53 module activation. Importantly, all genes were significantly associated with favourable EFS in an independent manner. Six of the signature genes, BSG/CD147, GNB2L1/RACK1, TXNDC5, FNPB1, B3GAT1, and IGSF10, play a role in cell differentiation. Our findings strongly suggest that the identified gene signature is a potential prognostic biomarker and therapeutic target for neuroblastoma patients and that it is associated with neuroblastoma cell differentiation through the activation of the NTRK1-PTPN6-TP53 module.
Endoscopic Ultrasound-Guided Gastroenterostomy versus Enteral Stenting for Malignant Gastric Outlet Obstruction: A Retrospective Propensity Score-Matched Study
Authors: Conti Bellocchi Maria Cristina , Gasparini Enrico , Stigliano Serena , Ramai Daryl , Bernardoni Laura , Di Matteo Francesco Maria , Facciorusso Antonio , Frulloni Luca , Crinò Stefano Francesco
Published: February 2024

Background: Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) using lumen apposing metal stent has emerged as a minimally invasive treatment for the management of malignant gastric outlet obstruction (mGOO). We aimed to compare EUS-GE with enteral stenting (ES) for the treatment of mGOO. Methods: Patients who underwent EUS-GE or ES for mGOO between June 2017 and June 2023 at two Italian centers were retrospectively identified. The primary outcome was stent dysfunction. Secondary outcomes included technical success, clinical failure, safety, and hospital length of stay. A propensity score-matching analysis was performed using multiple covariates. Results: Overall, 198 patients were included (66 EUS-GE and 132 ES). The stent dysfunction rate was 3.1% and 16.9% following EUS-GE and ES, respectively (p = 0.004). Using propensity score-matching, 45 patients were allocated to each group. The technical success rate was 100% for both groups. Stent dysfunction was higher in the ES group compared with the EUS-GE group (20% versus 4.4%, respectively; p = 0.022) without differences in clinical efficacy (p = 0.266) and safety (p = 0.085). A significantly shorter hospital stay was associated with EUS-GE compared with ES (7.5 ± 4.9 days vs. 12.5 ± 13.0 days, respectively; p = 0.018). Kaplan–Meier analyses confirmed a higher stent dysfunction-free survival rate after EUS-GE compared with ES (log-rank test; p = 0.05). Conclusion: EUS-GE offers lower rates of stent dysfunction, longer stent patency, and shorter hospital stay compared with ES.
Reply to Allaire, M.; Thabut, D. Comment on “Wu et al. Baveno VII Criteria Is an Accurate Risk Stratification Tool to Predict High-Risk Varices Requiring Intervention and Hepatic Events in Patients with Advanced Hepatocellular Carcinoma. Cancers 2023, 15, 2480”
Authors: Wu Claudia Wing-Kwan , Yip Terry Cheuk-Fung , Wong Vincent Wai-Sun , Wong Grace Lai-Hung , Liu Ken , Lui Rashid Nok-Shun
Published: February 2024

We thank Allaire et al [...]
Alternations of Blood Pressure Following Surgical or Drug Therapy for Prolactinomas
Authors: Cheng Yijun , Wang Dapeng , Tang Hao , Tong Debing , Zhao Weiguo , Lin Shaojian , Yao Hong , Lv Wenwen , Zhang Xun , Xue Li , Shang Hanbing , Wu Zhe Bao
Published: February 2024

Several subtypes of pituitary neuroendocrine tumors (PitNETs), such as acromegaly and Cushing’s disease, can result in hypertension. However, whether prolactinoma is associated with this complication remains unknown. Moreover, the effect of treatment with surgery or drugs on blood pressure (BP) is unknown. Herein, a retrospective study reviewed 162 patients with prolactinoma who underwent transsphenoidal surgery between January 2005 and December 2022. BP measurements were performed 1 day before and 5 days after surgery. Accordingly, patients’ medical characteristics were recorded. In addition, in situ rat and xenograft nude-mice prolactinoma models have been used to mimic prolactinoma. In vivo BP and serum prolactin (PRL) levels were measured after cabergoline (CAB) administration in both rats and mice. Our data suggest that surgery can effectively decrease BP in prolactinoma patients with or without hypertension. The BP-lowering effect was significantly associated with several variables, including age, sex, disease duration, tumor size, invasion, dopamine agonists (DAs)-resistance, recurrence, and preoperative PRL levels. Moreover, in situ and xenograft prolactinomas induced BP elevation, which was alleviated by CAB treatment without and with a statistical difference in rats and mice, respectively. Thus, surgery or CAB can decrease BP in prolactinoma, indicating that pre- and postoperative BP management becomes essential.
A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis
Authors: Ng Ethan , Tay John Rong Hao , Mattheos Nikos , Bostanci Nagihan , Belibasakis Georgios N. , Seneviratne Chaminda Jayampath
Published: February 2024

This mapping review highlights the need for a new paradigm in the understanding of peri-implantitis pathogenesis. The biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis is proposed, focusing on the relationship between biofilm, inflammation, and bone biology. The close interactions between immune and bone cells are discussed, with multiple stable states likely existing between clinically observable definitions of peri-implant health and peri-implantitis. The framework presented aims to explain the transition from health to disease as a staged and incremental process, where multiple factors contribute to distinct steps towards a tipping point where disease is manifested clinically. These steps might be reached in different ways in different patients and may constitute highly individualised paths. Notably, factors affecting the underlying biology are identified in the pathogenesis of peri-implantitis, highlighting that disruptions to the host–microbe homeostasis at the implant–mucosa interface may not be the sole factor. An improved understanding of disease pathogenesis will allow for intervention on multiple levels and a personalised treatment approach. Further research areas are identified, such as the use of novel biomarkers to detect changes in macrophage polarisation and activation status, and bone turnover.