bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced CO2 Adsorption Affinity in a NbO‐type MOF Constructed from a Low‐Cost Diisophthalate Ligand with a Piperazine‐Ring Bridge
Authors: Mu Qian , Wang Haiyan , Li Liangjun , Wang Chao , Wang Ying , Zhao Xuebo
Published: July 2015

A metal–organic framework (NPC‐6) with an NbO topology based on a piperazine ring‐bridged diisophthalate ligand was synthesized and characterized. The incorporated piperazine group leads to an enhanced adsorption affinity for CO2 in NPC‐6, in which the CO2 uptake is 4.83 mmol g−1 at 293 K and 1 bar, ranking among the top values of CO2 uptake on MOF materials. At 0.15 bar and 293 K, the NPC‐6 adsorbs 1.07 mmol g−1 of CO2, which is about 55.1 % higher than that of the analogue MOF NOTT‐101 under the same conditions. The enhanced CO2 uptake combined with comparable uptakes for CH4 and N2 leads to much higher selectivities for CO2/CH4 and CO2/N2 gas mixtures on NPC‐6 than on NOTT‐101. Furthermore, an N‐alkylation is used in the synthesis of the PDIA ligand, leading to a much lower cost compared with that in the synthesis of ligands in the NOTT series, as the former does not require a palladium‐based catalyst and borate esters. Thus, we conclude that NPC‐6 is a promising candidate for CO2 capture applications.
Opinion on potential health effects of exposure to electromagnetic fields
Authors:   Scientific Committee on Emerging Newly Identified Health Risks
Published: July 2015

In January 2015, the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) published its final opinion on “Potential health effects of exposure to electromagnetic fields.” The purpose of this document was to update previous SCENIHR opinions in the light of recently available information since then, and to give special consideration to areas that had not been dealt with in the previous opinions or in which important knowledge gaps had been identified. Bioelectromagnetics. 2015;9999:1–5. © 2015 Wiley Periodicals, Inc.
Phenotypic variability in bioprocessing conditions can be tracked on the basis of on‐line flow cytometry and fits to a scaling law
Authors: Baert Jonathan , Kinet Romain , Brognaux Alison , Delepierre Anissa , Telek Samuel , Sørensen Søren J. , Riber Leise , Fickers Patrick , Delvigne Frank
Published: July 2015

Noise in gene and protein expression is a major cause for bioprocess deviation. However, this phenomenon has been only scarcely considered in real bioprocessing conditions. In this work, a scaling‐law derived from genome‐scale studies based on GFP reporter systems has been calibrated to an on‐line flow cytometry device, allowing thus to get an insight at the level of promoter activity and associated noise during a whole microbial culture carried out in bioreactor. We show that most of the GFP reporter systems investigated and thus corresponding genes could be included inside the area covered by the scaling‐law. The experimental results suggest that this scaling‐law could be used to predict the dynamics of promoter activity, as well as the associated noise, in bioprocessing conditions. The knowledge acquired throughout this work could be used for the design of more robust expression systems.
Porous Silica Particles as Oil Absorbents: Comparison of Meso‐, Macro‐, and Meso/Macro‐Structures
Authors: Kim Kwang‐Dae , Cho Youn Kyoung , Han Sang Wook , Park Eun Ji , Kim Dae Han , Jeong Myung‐Geun , Kim Young Dok , Moon Jongwoo , Hong Eunmi , Lim Dong Chan
Published: July 2015

Silica particles with three different pore structures were synthesized, consisting of only‐meso‐, only‐macro‐, and both meso/macro‐pores. The meso‐pores were approximately 3–30 nm in diameter, whereas the macro‐pores were larger than 500 nm. By using chemical vapor deposition of polydimethylsiloxane (PDMS) on porous silica, the surfaces of the silica became completely hydrophobic. The surfaces on which the PDMS‐coated silica particles were distributed showed water contact angles close to 170° and the particles floated perfectly on water. The silica with both meso‐ and macro‐pores showed a much higher oil absorption capacity (2.5–3 times higher capacity) than the other samples with either only meso‐ or macro‐pores. The superior oil absorption capacity of the meso/macro‐porous silica was primarily attributed to the extraordinarily high porosity.
Development of an Automated, High‐throughput Sample Preparation Protocol for Proteomics Analysis
Authors: Arul Albert‐Baskar , Byambadorj Munkhtsolmon , Han Na‐Young , Park Jong Moon , Lee Hookeun
Published: July 2015

Sample preparation for proteomics analysis is one of the most crucial processes that is often time consuming and laborious, which makes parallel handling of high‐throughput samples difficult. In proteomics studies, availability of reproducible and sensitive methods is a prerequisite for qualitative and quantitative analyses of high‐throughput data to identify potential biomarker candidates from biological samples. The greatest strength of any sample preparation protocol is the reproducibility of extraction, solubilization, and digestion of proteins. Therefore, the present study was planned to automate filter‐aided sample preparation (FASP) protocol that is widely used at present in proteomics analysis. We tested the efficiency of an automated sample preparation platform for handling 96 samples in parallel, which reduced the time and cost of analysis. Samples were added to a 96‐well filter plate, and proteins present in the samples were trapped, denatured, reduced, alkylated, and digested with trypsin. The eluted peptides were analyzed using mass spectrometry MS/MS. Buffer exchanges, which were previously performed using centrifugation, were performed by controlling the vacuum pressure. Different concentrations of bovine serum albumin (BSA) were used for optimizing the pressure and time required for the efficient elution and identification of peptides. The optimized conditions were evaluated using tissue samples with manual and automated FASP protocols and the eluted peptides were analyzed using liquid chromatography LC‐MS/MS. Results showed that the automated FASP (a‐FASP) protocol could efficiently handle large sample sets in a reproducible and quantifiable manner. Thus, inclusion of this automated protocol in proteomics analysis could help in handling high‐throughput data in less time and with minimal error.
Electronic Structure of Superconducting Ta4Pd3Te16
Authors: Lee Wang‐Ro , Cho Sung‐Woo , Nam Dae‐Hyun , Jung Dongwoon
Published: July 2015

The electronic structure of Ta4Pd3Te16 was analyzed by tight‐binding band calculations based on the given structure. The compound electronically showed quasi‐one‐dimensional behavior even though it comprised a two‐dimensional layered structure. A strong orbital interaction was found only along the crystallographic b‐direction of the compound. Fermi surface nesting disappeared in Ta4Pd3Te16 because of the weak interaction between Ta–Te and Pd–Te polyhedra. It was found, therefore, that this compound could be a superconductor through suppression of the charge‐density wave state via disappearance of Fermi surface nesting.
Spectrophotometric Determination of Affinities of α‐Factors for Their G Protein‐Coupled Receptors in Saccharomyces cerevisiae
Authors: Ahn Hee Jun , Kim Hyung Jin , Jin Dong Hoon , Hong Nam Joo
Published: July 2015

A new and relatively simple spectrophotometric technique has been developed for the accurate determination of α‐factor pheromone affinities for Ste2p whole cell receptor in yeast a‐cells. We designed and tested nine detector peptides containing mono‐ (ε412 = 14 500) or tri‐cysteine residues (ε412 = 43 660). The free unbound detector was detected using Ellman's reagent at 412 nm. Saturation binding studies using Saccharomyces cerevisiae Y 7925 (
MATa
) at a concentration of 2.5 × 1011 cells/mL with the highest affinity detector 1, [Orn6]α‐factor‐[Cys]3, resulted in a dissociation constant (
K
D
) of 1.67 × 10−7 and total binding sites per cell (B
cell = 29 500 sites/cell) comparable with those obtained using radiolabeled binding assays. Competitive binding assay using five nonchromogenic α‐factor analogs allowed for the determination of each
K
D
value. [Orn6,d‐Ala9]α‐factor showed the highest receptor affinity (
K
D
 = 1.03 × 10−7 M), which was threefold higher than that of native α‐factor. This assay provides rapid and convenient results for determining the relative affinities of nonchromogenic α‐factors and eliminates the need for radioactive waste disposal.
An efficient in vitro and in vivo HPLC method for hydnocarpin in nanomicelles formulation
Authors: Feng Yingshu , Sun Congyong , Omari‐Siaw Emmanuel , Zhu Yuan , Tong Shanshan , Wan Jinyi , Yu Jiangnan , Xu Ximing
Published: July 2015

For quantitative and other related bioactive studies of hydnocarpin, there is a need to establish an efficient, specific and sensitive analytical method (in vitro and in vivo). In this paper, an efficient HPLC method has been established and validated to analyze hydnocarpin in a nanomicelle formulation for the first time. Various chromatographic conditions for in vitro and in vivo determinations were investigated, with the application examined by pharmacokinetics and tissue distribution studies. The analysis was carried out using an HPLC system with a Waters symmetry C18 column (4.6 × 150 mm, 5 µm) at 25°C with a detecting wavelength of 342 nm. Eluting at a rate of 1.0 mL/min, a 65% methanol and 35% acetic acid solution (0.1%) served as the mobile phase for the in vitro determinations while a 62% methanol and 38% acetic acid solution (0.1%) was used for in vivo analysis with isoliquiritigenin as internal standard. The established in vitro linearity range for hydnocarpin was 0.2–20 µg/mL (R2 = 0.9996), with the biological (in vivo) samples following the same trend. The accuracy of the method was >99% (in vitro) and 92.4–105.3% (in vivo). Also, the precision met the acceptance criterion. These results indicate that the established method exhibited high specificity, accuracy, linearity and precision. Additionally, this efficient HPLC method was applied to pharmacokinetics and tissue distribution studies. Copyright © 2015 John Wiley & Sons, Ltd.
Essential Oils and Chemical Diversity of Southeast European Populations of Salvia officinalis L.
Authors: Cvetkovikj Ivana , Stefkov Gjoshe , Karapandzova Marija , Kulevanova Svetlana , Satović Zlatko
Published: July 2015

The essential oils of 25 populations of Dalmatian sage (Salvia officinalis L.) from nine Balkan countries, including 17 indigenous populations (representing almost the entire native distribution area) and eight non‐indigenous (cultivated or naturalized) populations were analyzed. Their essential‐oil yield ranged from 0.25 to 3.48%. Within the total of 80 detected compounds, ten (β‐pinene, 1,8‐cineole, cis‐thujone, trans‐thujone, camphor, borneol, trans‐caryophyllene, α‐humulene, viridiflorol, and manool) represented 42.60 to 85.70% of the components in the analyzed essential oils. Strong positive correlations were observed between the contents of trans‐caryophyllene and α‐humulene, α‐humulene and viridiflorol, and viridiflorol and manool. Principal component analysis (PCA) on the basis of the contents of the ten main compounds showed that four principal components had an eigenvalue greater than 1 and explained 79.87% of the total variation. Performing cluster analysis (CA), the sage populations could be grouped into four distinct chemotypes (A–D). The essential oils of 14 out of the 25 populations of Dalmatian sage belonged to Chemotype A and were rich in cis‐thujone and camphor, with low contents of trans‐thujone. The correlation between the essential‐oil composition and geographic variables of the indigenous populations was not significant; hence, the similarities in the essential‐oil profile among populations could not be explained by the physical proximity of the populations. Additionally, the southeastern populations tended to have higher EO yields than the northwestern ones.
Expanding the Genetic Code for a Dinitrophenyl Hapten
Authors: Ren Wei , Ji Ao , Wang Michael X. , Ai Hui‐wang
Published: July 2015

Haptens, such as dinitrophenyl (DNP) are small molecules that induce strong immune responses when attached to proteins or peptides and, as such, have been exploited for diverse applications. We engineered a Methanosarcina barkeri pyrrolysyl‐tRNA synthetase (mbPylRS) to genetically encode a DNP‐containing unnatural amino acid, N6‐(2‐(2,4‐dinitrophenyl)acetyl)lysine (DnpK). Although this moiety was unstable in Escherichia coli, we found that its stability was enhanced in mammalian HEK 293T cells and was able to induce selective interactions with anti‐DNP antibodies. The capability of genetically introducing DNP into proteins is expected to find broad applications in biosensing, immunology, and therapeutics.
Hydrogenation of Nitrobenzene over a Pd/Al2O3 Catalyst – Mechanism and Effect of the Main Operating Conditions
Authors: Couto Clara Sá , Madeira Luis M. , Nunes Clemente Pedro , Araújo Paulo
Published: July 2015

The catalytic hydrogenation of nitrobenzene (NB) was studied in a three‐phase basket reactor with a commercial Pd/Al2O3 sample as catalyst. The kinetic experiments allowed a better understanding of the mechanism behind the formation of aniline (ANL) and by‐products, a topic not yet well comprehended. The effect of some operating conditions was studied and the existence of more by‐products than mentioned in the literature was stated; specifically, benzene formation was verified. Both the reaction kinetics and selectivity were found to be strongly dependent on the temperature, while the effect of total pressure is not that pronounced. Moreover, the high selectivity of the catalyst used in the present work was proved, and as such the deep hydrogenation of ANL to form by‐products only occurs in considerable extension when the NB concentration in the reaction mixture becomes negligible.
ChemInform Abstract: Crystal Structure of Ba5In4Sb6.
Authors: Pan Ming‐Yan , Xia Sheng‐Qing , Tao Xu‐Tang
Published: July 2015

Single crystals of Ba5In4Sb6 are grown from a reactive indium flux using a molar mixture of Ba:In:Sb of 3:30:5 (alumina crucible, 1173 K, 20 h; cooling to 773 K at a rate of 2 k/h).
ChemInform Abstract: Preparation of p‐Type AgCrO2 Nanocrystals Through Low‐Temperature Hydrothermal Method and the Potential Application in p‐Type Dye‐Sensitized Solar Cell.
Authors: Xiong Dehua , Wang Huan , Zhang Wenjun , Zeng Xianwei , Chang Haimei , Zhao Xiujian , Chen Wei , Cheng Yi‐Bing
Published: July 2015

Phase‐pure AgCrO2 nanocrystals 10‐20 nm in size are hydrothermally grown from aqueous solutions of AgNO3, Cr(NO3)3, and NaOH as mineralizer (autoclave, 190‐230 °C, 60 h).
ChemInform Abstract: Honeycomb‐Like Macro‐Germanium as High‐Capacity Anodes for Lithium‐Ion Batteries with Good Cycling and Rate Performance.
Authors: Liang Jianwen , Li Xiaona , Hou Zhiguo , Zhang Tianwen , Zhu Yongchun , Yan Xuedong , Qian Yitai
Published: July 2015

Macroporous Ge powder is prepared by reduction of commercial GeO2 with Mg under hydrothermal conditions (autoclave, 200 °C, 5 h).
ChemInform Abstract: Synthesis, Crystal, and Electronic Structure of Ba3Sb2Q7 (Q: S, Se).
Authors: Wang Jian , Lee Kathleen , Kovnir Kirill
Published: July 2015

The new title compounds are synthesized by solid state reactions of stoichiometric mixtures of the elements (773 K for 24 h, 1173 K for 168 h, and 923 K for 96 h) and characterized by single crystal XRD, UV/VIS diffuse reflectance spectroscopy, and quantum chemical TB‐LMTO‐ASA computations.
ChemInform Abstract: Cobalt‐Catalyzed Asymmetric Hydroboration of Aryl Ketones with Pinacolborane.
Authors: Guo Jun , Chen Jianhui , Lu Zhan
Published: July 2015

A highly enantioselective hydroboration of aryl ketones with pinacolborane under mild reaction conditions is developed.
ChemInform Abstract: Ruthenium‐Catalyzed Synthesis of 2,3‐Cyclo[3]dendralenes and Complex Polycycles from Propargyl Alcohols.
Authors: Thies Nora , Haak Edgar
Published: July 2015

Multicomponent cascade transformations of unsaturated alcohols, catalyzed by cyclopentadienone ruthenium complexes, yield complex polycyclic products with up to nine stereogenic centers.
ChemInform Abstract: Conformationally Constrained Penta(hetero)cyclic Molecular Architectures by Photoassisted Diversity‐Oriented Synthesis.
Authors: Umstead Weston J. , Mukhina Olga A. , Kutateladze Andrei G.
Published: July 2015

Fused hydantoins [(V) and (VI)], oxazolidinones [(X), (XIV), and (XV)], and imidazolines [(XIX) and (XX)] are synthesized through photoinduced intramolecular cycloadditions of appropriate precursors containing acylurea (IV), urethane [(IX) or (XIII), resp.], or urea (XVIII) linkers, respectively.
ChemInform Abstract: Catalytic Aerobic Oxidation of Alcohols Using Recoverable IAPNO α‐Hydrogen Nitroxyl Radicals.
Authors: Bar Sukanta , Kumar Jayprakash N. , Amar Michal , Toledo Hila , Batrice Rami J. , Szpilman Alex M.
Published: July 2015

Conditions for the oxidation of primary aliphatic, benzylic, allylic, and propargylic alcohols and secondary benzylic alcohols including benzoin in the presence of newly developed stable α‐hydrogen nitroxyl radicals as the catalyst are elaborated.
ChemInform Abstract: Temperature‐Controlled Bidirectional Enantioselectivity in a Dynamic Catalyst for Asymmetric Hydrogenation.
Authors: Storch Golo , Trapp Oliver
Published: July 2015

A stereochemically flexible diastereomeric catalyst (I) is prepared and used in the asymmetric hydrogenation of aminocarboxylic acids (II)/(IV) and diester (VI).
ChemInform Abstract: Efficient Asymmetric Transfer Hydrogenation of Ketones in Ethanol with Chiral Iridium Complexes of spiroPAP Ligands as Catalysts.
Authors: Liu Wei‐Peng , Yuan Ming‐Lei , Yang Xiao‐Hui , Li Ke , Xie Jian‐Hua , Zhou Qi‐Lin
Published: July 2015

Chiral alcohols [(II) and (IV)] are simply and efficiently synthesized with up to 98% e.e.
ChemInform Abstract: Visible‐Light‐Induced Chemoselective Reductive Decarboxylative Alkynylation under Biomolecule‐Compatible Conditions.
Authors: Yang Jie , Zhang Jing , Qi Li , Hu Chenchen , Chen Yiyun
Published: July 2015

Various aryl‐, alkyl‐, and silyl‐substituted alkynes are chemoselectively obtained with excellent functional group compatibility.
ChemInform Abstract: De novo Synthesis of Functionalized 1,3‐Enynes and Extended Conjugated Molecular Systems.
Authors: Rao Maddali L. N. , Dasgupta Priyabrata , Murty Venneti N.
Published: July 2015

A new palladium catalyzed reaction of 1,3‐dienyldibromides with triarylbismuths to give a wide range of 1,3‐enynes is demonstrated.
ChemInform Abstract: Copper‐Catalyzed Asymmetric Allylation of Chiral N‐tert‐Butanesulfinyl Imines: Dual Stereocontrol with Nearly Perfect Diastereoselectivity.
Authors: Zhao Yi‐Shuang , Liu Qiang , Tian Ping , Tao Jing‐Chao , Lin Guo‐Qiang
Published: July 2015

A BINOL‐derived phosphoramidite ligand is successfully applied in the copper‐catalyzed asymmetric allylation of chiral N‐tert‐butanesulfinyl aldimines (I) and ketimines (IV) leading to homoallylic amines with high diastereoselectivity.
ChemInform Abstract: Diaryliodonium Salts as Efficient Lewis Acid Catalysts for Direct Three Component Mannich Reactions.
Authors: Zhang Yanxia , Han Jianwei , Liu Zhen‐Jiang
Published: July 2015

The reaction is performed under solvent free conditions and the catalyst can be recycled without significant loss of activity.
ChemInform Abstract: Condensed‐Phase, Halogen‐Bonded CF3I and C2F5I Adducts for Perfluoroalkylation Reactions.
Authors: Sladojevich Filippo , McNeill Eric , Boergel Jonas , Zheng Shao‐Liang , Ritter Tobias
Published: July 2015

Tetramethylguanidine and DMSO can be used to prepare the required adducts of type (I), (IX), and (XIV).
ChemInform Abstract: Enantioselective Redox‐Neutral Rh‐Catalyzed Coupling of Terminal Alkynes with Carboxylic Acids Toward Branched Allylic Esters.
Authors: Koschker Philipp , Kaehny Matthias , Breit Bernhard
Published: July 2015

The scalable, highly enantioselective reaction procedure delivers allylic esters with high regioselectivity in favor of the branched vs.
ChemInform Abstract: A Novel Rhodium‐Catalyzed Domino‐Hydroformylation‐Reaction for the Synthesis of Sulphonamides.
Authors: Dong Kaiwu , Fang Xianjie , Jackstell Ralf , Beller Matthias
Published: July 2015

An efficient and highly selective method for the synthesis of sulfonamides by a new domino hydroformylation‐reductive sulfonamidation reaction is presented.
ChemInform Abstract: Metal‐Free Oxidative Decarbonylative Coupling of Aromatic Aldehydes with Arenes: Direct Access to Biaryls.
Authors: Tang Ren‐Jin , He Qing , Yang Luo
Published: July 2015

The reaction proceeds through a non‐chain radical hemolytic aromatic substitution (HAS).
ChemInform Abstract: Microwave‐Assisted Oxidation of Indan‐1‐ones into Ninhydrins.
Authors: Marminon Christelle , Nacereddine Abdelhamid , Bouaziz Zouhair , Nebois Pascal , Jose Joachim , Le Borgne Marc
Published: July 2015

The convenient oxidation using SeO2 as the oxidant tolerates a wide variety of substituents on the aromatic ring.
ChemInform Abstract: Synthesis of Functionalized γ‐Lactone via Sakurai exo‐Cyclization/Rearrangement of 3,3‐Bis(silyl) Enol Ester with a Tethered Acetal.
Authors: Yin Zhiping , Liu Zengjin , Huang Zhenggang , Chu Yang , Chu Zhiwen , Hu Jia , Gao Lu , Song Zhenlei
Published: July 2015

An efficient synthesis of functionalized γ‐lactones is developed.
ChemInform Abstract: Copper‐Mediated Tandem Reaction of β‐Ketoesters/Ketones with Tertiary Amines for the Synthesis of 2,3‐Dihydrofurans.
Authors: Guo Shengmei , Lu Lin , Gong Jiuhan , Zhu Zheng , Xu Feng , Wei Zhenhong , Cai Hu
Published: July 2015

A series of β‐keto esters and β‐diketones is examined giving the desired products in moderate to excellent yields.
ChemInform Abstract: Formal anti‐Carbopalladation Reactions of Non‐Activated Alkynes: Requirements, Mechanistic Insights, and Applications.
Authors: Pawliczek Martin , Schneider Tobias F. , Maass Christian , Stalke Dietmar , Werz Daniel B.
Published: July 2015

Alkyne systems are designed which are able to undergo a distinct, formal anti‐carbopalladation.
ChemInform Abstract: Broensted Acid‐Catalyzed Enantioselective Synthesis of Isatin‐ Derived N,S‐Acetals.
Authors: Beceno Christian , Chauhan Pankaj , Rembiak Andreas , Wang Ai , Enders Dieter
Published: July 2015

The isatin‐derived N,S‐acetals are synthesized in high yields and high enantioselectivities from nucleophilic addition of thiols to isatin‐derived ketimines using BINOL‐derived phosphoric acid as catalyst.
ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Enantioselective Decarboxylative Alkylation of β‐Keto Acids with 3‐Hydroxy‐3‐indolyloxindoles.
Authors: Tang Xiao‐Dong , Li Shen , Guo Ran , Nie Jing , Ma Jun‐An
Published: July 2015

The method tolerates a variety of aryl, hetaryl, and alkyl β‐keto acids and furnishes the desired 3‐functionalized 3‐indolyloxindoles with an all‐quaternary stereocenter in high yields and enantioselectivities.
ChemInform Abstract: Access to Polysubstituted Indoles or Benzothiophenes via Palladium‐Catalyzed Cross‐Coupling of Furfural Tosylhydrazones with 2‐Iodoanilines or 2‐Iodothiophenols.
Authors: Yin Biaolin , Zhang Xiaoyu , Zhang Xiaoting , Peng Hui , Zhou Wen , Liu Bo , Jiang Huanfeng
Published: July 2015

Polysubstituted indoles [(III), (VI), and (IX)] or benzothiophenes (XI) are efficiently synthesized by cross‐coupling of readily available furfural tosylhydrazones [(II), (V), or (VIII), resp.] with 2‐iodoanilines or 2‐iodothiophenol, respectively.
ChemInform Abstract: Asymmetric Dearomatization of Indoles Through a Michael/Friedel—Crafts‐Type Cascade to Construct Polycyclic Spiroindolines.
Authors: Zhao Xiaohu , Liu Xiaohua , Mei Hongjiang , Guo Jing , Lin Lili , Feng Xiaoming
Published: July 2015

Asymmetric dearomatization of indoles is achieved by a cascade reaction between isocyanoethylindole and alkylidene malonates catalyzed by a chiral N,N‐dioxide/Mg catalyst.
ChemInform Abstract: Synthesis of Pyrazoles from 1,3‐Diols via Hydrogen Transfer Catalysis.
Authors: Schmitt Daniel C. , Taylor Alexandria P. , Flick Andrew C. , Kyne Robert E. Jr.
Published: July 2015

Starting from 2‐alkyl or 2‐aryl substituted 1,3‐diols and alkyl or aryl hydrazines a scalable protocol for the preparation of otherwise hardly accessible 4‐substituted pyrazoles is elaborated.
ChemInform Abstract: Catalytic Cyclization Reactions of Huisgen Zwitterion with α‐Ketoesters by in situ Chemoselective Phosphine Oxide Reduction.
Authors: Fourmy Kevin , Voituriez Arnaud
Published: July 2015

The first examples of catalytic cyclization reactions of the Huisgen zwitterion with α‐ketoesters are described.
ChemInform Abstract: Radical‐Based Route to 2‐(Trifluoromethyl)‐1,3,4‐oxadiazoles and Trifluoromethyl‐Substituted Polycyclic 1,2,4‐Triazoles and Dihydrofurans.
Authors: Qin Ling , Zard Samir Z.
Published: July 2015

Various trifluoromethyl‐substituted structures can be obtained by exploitation of the 2‐(trifluoromethyl)‐1,3,4‐oxadiazolyl‐5‐methyl radical.
ChemInform Abstract: Oxidative Povarov Reaction via sp3 C—H Oxidation of N‐Benzylanilines Induced by Catalytic Radical Cation Salt: Synthesis of 2,4‐Diarylquinoline Derivatives.
Authors: Liu Jing , Liu Fang , Zhu Yingzu , Ma Xingge , Jia Xiaodong
Published: July 2015

The reaction tolerates differently substituted N‐benzylic aniline derivatives and styrene derivatives, but is not applicable to α‐methylstyrene.
ChemInform Abstract: Base‐Promoted Cross‐Dehydrogenative Coupling of Quinoline N‐Oxides with 1,3‐Azoles.
Authors: Chen Xiaopei , Cui Xiuling , Yang Fangfang , Wu Yangjie
Published: July 2015

A simple protocol for the preparation of biheteroaryls is developed based on the coupling of substituted quinoline N‐oxides and 1,3‐benzoxazoles.
ChemInform Abstract: Novel One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones and 3,4,7,8‐ Tetrahydroquinazoline‐2,5‐diones Using Pyridinium p‐Toluenesulfonate as Catalyst.
Authors: Khodja Imene Amine , Boulcina Raouf , Debache Abdelmadjid
Published: July 2015

Simple and efficient procedure for the synthesis of the title heterocycles (IV) and (VI), resp., using multicomponent reactions are described.
ChemInform Abstract: Direct Introduction of a Naphthalene‐1,8‐diamino Boryl [B(dan)] Group by a Pd‐Catalyzed Selective Boryl Transfer Reaction.
Authors: Xu Liang , Li Pengfei
Published: July 2015

The non‐symmetrical diboron compound, B(pin)—B(dan) (I), is employed as borylating reagent in the Pd‐catalyzed Miyaura‐type reaction.
ChemInform Abstract: Transition‐Metal‐Free Direct anti‐Carboboration of Alkynes with Boronic Acids to Produce Alkenylheteroarenes.
Authors: Roscales Silvia , Csaky Aurelio G.
Published: July 2015

A new protocol for the intermolecular direct anti‐carboboration by using tartaric acid as promoter and boronic acids as reactants is presented.
ChemInform Abstract: New and Efficient Methodology for the Synthesis of Chiral Mono‐ and Ditellurides.
Authors: Scianowski Jacek , Pacula Agata J. , Wojtczak Andrzej
Published: July 2015

The preparation of sodium mono‐ and sodiumditelluride is elaborated.
ChemInform Abstract: Borylstannylation of Alkynes with Inverse Regioselectivity: Copper‐Catalyzed Three‐Component Coupling Using a Masked Diboron.
Authors: Yoshida H. , Takemoto Y. , Takaki K.
Published: July 2015

The three‐component borylstannylation reaction of terminal alkynes proceeds with inverse regioselectivity in the presence of a copper catalyst using a masked diboron compound giving diverse cis‐boryl(stannyl)alkenes.
ChemInform Abstract: Nine New Diterpenes from the Leaves of Plantation‐Grown Cunninghamia lanceolata.
Authors: Zhao Shuangshuang , Ling Junhong , Li Zhanlin , Wang Silong , Hu Jiangchun , Wang Nan
Published: July 2015

9 New diterpenes are isolated from the leaves of plantation‐grown Cunninghamia lanceolata along with 12 known compounds.
ChemInform Abstract: Synthesis of D‐ and L‐Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process.
Authors: Parmeggiani Fabio , Lovelock Sarah L. , Weise Nicholas J. , Ahmed Syed T. , Turner Nicholas J.
Published: July 2015

Starting from inexpensive cinnamic acids, a novel chemoenzymatic cascade one‐pot approach to D‐phenylalanine derivatives is developed.
ChemInform Abstract: Oximoaspergillimide, a Fungal Derivative from a Marine Isolate of Aspergillus sp.
Authors: Cardoso‐Martinez Faviola , de la Rosa Jose M. , Diaz‐Marrero Ana R. , Darias Jose , D'Croz Luis , Cerella Claudia , Diederich Marc , Cueto Mercedes
Published: July 2015

isolation and structure elucidation of oximoaspergillimide (I)
ChemInform Abstract: Pd—Imidate Complexes as Recyclable Catalysts for the Synthesis of C5‐Alkenylated Pyrimidine Nucleosides via Heck Cross‐Coupling Reaction.
Authors: Ardhapure Ajaykumar V. , Sanghvi Yogesh S. , Kapdi Anant R. , Garcia Joaquin , Sanchez Gregorio , Lozano Pedro , Serrano J. Luis
Published: July 2015

The new approach is used for the highly efficient scale‐up synthesis of the HSV‐1 inhibitor Brivudine (BVDU) (IV).
ChemInform Abstract: Layer‐by‐Layer Assembly for Graphene‐Based Multilayer Nanocomposites: Synthesis and Applications
Authors: Lee Taemin , Min Sa Hoon , Gu Minsu , Jung Yun Kyung , Lee Wonoh , Lee Jea Uk , Seong Dong Gi , Kim Byeong‐Su
Published: July 2015

Review: 101 refs.
ChemInform Abstract: Rational Design of Metal Nanoframes for Catalysis and Plasmonics
Authors: Fang Zhicheng , Wang Youcheng , Liu Chenxuan , Chen Sheng , Sang Wei , Wang Chao , Zeng Jie
Published: July 2015

Review: 92 refs.
ChemInform Abstract: Application of Nucleophilic Substitution of Hydrogen in Nitroarenes to the Chemistry of Indoles
Authors: Makosza Mieczyslaw , Wojciechowski Krzysztof
Published: July 2015

Review: 108 refs.
ChemInform Abstract: Selective Incorporation of Fluorine in Pyrazoles
Authors: Sloop Joseph C. , Holder Cory , Henary Maged
Published: July 2015

Review: [103 refs.
ChemInform Abstract: Asymmetric C—H Functionalization Involving Organocatalysis
Authors: Zhao Yong‐Long , Wang Yao , Luo Yong‐Chun , Fu Xiao‐Zhong , Xu Peng‐Fei
Published: July 2015

Review: [46 refs.
ChemInform Abstract: Rhodium(II)‐Catalyzed Intramolecular C—H Insertion α‐ to Oxygen: Reactivity, Selectivity and Applications to Natural Product Synthesis
Authors: Lombard Fanny J. , Coster Mark J.
Published: July 2015

Review: 68 refs.
ChemInform Abstract: Nickel Catalysts/N,N′‐Bidentate Directing Groups: An Excellent Partnership in Directed C—H Activation Reactions
Authors: Castro Luis C. Misal , Chatani Naoto
Published: July 2015

Review: [39 refs.
ChemInform Abstract: Sulfonated Polyethylene Glycol (PEG‐OSO3H) as a Polymer Supported Biodegradable and Recyclable Catalyst in Green Organic Synthesis: Recent Advances
Authors: Vekariya Rajesh H. , Patel Hitesh D.
Published: July 2015

Review: 195 refs.
ChemInform Abstract: Potential Effect of Ultrasound on Carbohydrates
Authors: Bera Smritilekha , Mondal Dhananjoy , Martin Jacob T. , Singh Man
Published: July 2015

Review: 154 refs.
ChemInform Abstract: Influence of Sulfur for Oxygen Substitution in the Solvolytic Reactions of Chloroformate Esters and Related Compounds
Authors: D'Souza Malcolm J. , Kevill Dennis N.
Published: July 2015

Review: 88 refs.
ChemInform Abstract: Biomass‐Derived Porous Carbon Materials: Synthesis and Catalytic Applications
Authors: De Sudipta , Balu Alina Mariana , van der Waal Jan C. , Luque Rafael
Published: July 2015

Review: [111 refs.
ChemInform Abstract: The Role of Antioxidants in the Chemistry of Oxidative Stress: A Review
Authors: Pisoschi Aurelia Magdalena , Pop Aneta
Published: July 2015

Review: 303 refs.
ChemInform Abstract: Quinine Conjugates and Quinine Analogues as Potential Antimalarial Agents
Authors: Jones Rachel A. , Panda Siva S. , Hall C. Dennis
Published: July 2015

Review: [89 refs.
ChemInform Abstract: Applications of Graphene and Its Derivatives as an Adsorbent for Heavy Metal and Dye Removal: A Systematic and Comprehensive Overview
Authors: Yusuf Mohammed , Elfghi F. M. , Zaidi Shabi Abbas , Abdullah E. C. , Khan Moonis Ali
Published: July 2015

Review: 168 refs.
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
Authors: Royo Santiago , Rodríguez Santiago , Schirmeister Tanja , Kesselring Jochen , Kaiser Marcel , González Florenci V.
Published: July 2015

Dipeptidyl enoates were prepared through a high‐yielding two‐step synthetic route. They have a dipeptidic structure with a 4‐oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)‐ethyl 5‐((S)‐2‐{[(benzyloxy)carbonyl]amino}‐3‐phenylpropanamido)‐7‐methyl‐4‐oxooct‐2‐enoate (6) was the most potent, with an IC50 value of 16.4 nM and kinact/Ki=1.6×106 M−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition kinetics data, supported by docking studies, suggest a dual mode of action via attack of cysteine thiolate at two reactive positions.
Diffusion on a molecular scale as observed using PGSE NMR
Authors: Phillies George D.J.
Published: July 2015

For half a century, pulsed‐gradient Spin‐Echo NMR based on the Stejskal–Tanner equation has been used to infer Fick's‐Law diffusion coefficients of solutes in simple liquids and complex fluids. The decades since the original papers have seen vast advances in instrument technology and pulse sequence design, all leading to improved measurements of diffusion coefficients. However, just as the last half‐century has brought major advances in instrument technology, so also it has also brought major advances in scientific understanding of diffusion on molecular distance and time scales. This article discusses implications of these advances in molecular hydrodynamics for the interpretation of PGSE NMR attenuation curves. The results here are particularly significant for studies on complex fluid systems that have relaxations on the time and distance scales that are observed in PGSE NMR experiments. © 2015 Wiley Periodicals, Inc. Concepts Magn Reson Part A 43A: 1–15, 2015.
Connectivity and neurochemistry of the commissura anterior of the pigeon (Columba livia)
Authors: Letzner Sara , Simon Annika , Güntürkün Onur
Published: July 2015

The anterior commissure (AC) and the much smaller hippocampal commissure constitute the only interhemispheric pathways at the telencephalic level in birds. Since the degeneration study from Zeier and Karten (), no detailed description of the topographic organization of the AC has been performed. This information is not only necessary for a better understanding of interhemispheric transfer in birds, but also for a comparative analysis of the evolution of commissural systems in the vertebrate classes. We therefore examined the fiber connections of the AC by using choleratoxin subunit B (CTB) and biotinylated dextran amine (BDA). Injections into subareas of the arcopallium and posterior amygdala (PoA) demonstrated contralateral projection fields within the anterior arcopallium (AA), intermediate arcopallium (AI), PoA, lateral, caudolateral and central nidopallium, dorsal and ventral mesopallium, and medial striatum (MSt). Interestingly, only arcopallial and amygdaloid projections were reciprocally organized, and all AC projections originated within a rather small area of the arcopallium and the PoA. The commissural neurons were not GABA‐positive, and thus possibly not of an inhibitory nature. In sum, our neuroanatomical study demonstrates that a small group of arcopallial and amygdaloid neurons constitute a wide range of contralateral projections to sensorimotor and limbic structures. Different from mammals, in birds the neurons that project via the AC constitute mostly heterotopically organized and unidirectional connections. In addition, the great majority of pallial areas do not participate by themselves in interhemispheric exchange in birds. Instead, commissural exchange rests on a rather small arcopallial and amygdaloid cluster of neurons. J. Comp. Neurol. 524:343–361, 2016. © 2015 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
Aspiration cytology of primary thyroid paraganglioma
Authors: Zhang Wei , Policarpio‐Nicolas Maria Luisa C.
Published: July 2015

Thyroid paragangliomas are extremely rare tumors arising from the inferior laryngeal paraganglia. Most patients are female and present as asymptomatic thyroid nodule. Diagnosing thyroid paraganglioma can be difficult on fine‐needle aspiration (FNA) since it could be misdiagnosed as medullary thyroid carcinoma, calcitonin‐negative neuroendocrine tumor of the thyroid gland (CNNETT), metastatic neuroendocrine tumor, and intrathyroid parathyroid proliferation. We describe the cytologic features and immunohistochemical staining pattern of thyroid paraganglioma from a 60‐year‐old woman with a gradually enlarging neck mass for several months. An ultrasound guided fine‐needle aspiration was performed which revealed epithelioid, plasmacytoid to occasionally spindle‐shaped cells with ovoid to elongated nuclei, fine chromatin pattern and inconspicuous nucleoli. The cells were arranged singly, in sheets, and focally in acinar pattern. Occasional nuclear overlapping, crush artifact, and binucleated cells were identified. Neither colloid nor amyloid was seen. Immunohistochemical stains performed on the cell block showed the tumor cells were positive for neuroendocrine markers and negative for cytokeratin (AE1/AE3), calcitonin, CEA, thyroglobulin, and TTF‐1. There were rare S‐100 positive cells. Given the difference in management of paragangliomas compared to its cytology mimics and association with familial cancer syndromes in some cases, awareness of this rare tumor, and use of immunohistochemical stains are critical in arriving at the diagnosis. Diagn. Cytopathol. 2015;43:838–843. © 2015 Wiley Periodicals, Inc.
Review lessons learned from OCR complaint, resolution
Authors: Hope Joan
Published: July 2015

For years, disability services providers at the University of Montana worked to raise awareness of the needs of students with disabilities. An Office for Civil Rights complaint and its resolution agreement made accessibility a topic everyone on campus is aware of and changed the way officials across campus think about accessibility.
Consider your campus housing policy on emotional support animals in light of legal claims
Authors: Masinter Michael R.
Published: July 2015

In 2011, the Justice Department sued the University of Nebraska at Kearney and several of its officials under the Fair Housing Act. DOJ alleged two basic claims — the defendants unlawfully denied requests by two students to permit emotional support animals in campus housing as accommodations for depression, anxiety and post‐traumatic stress disorder, and the institution had a pattern and practice of disability discrimination against students seeking to live with emotional support animals as accommodations for psychiatric disabilities.
Experimental Compensation for Difference between Small‐Particle Aggregates and Substitute Large Particles in Ultrasonic Spectroscopy
Authors: ARIMA MASAHIRO , SATO TAKAYUKI , WATANABE YASUAKI
Published: July 2015

The measurement of blood viscosity in the human body is very important for preventing diabetes mellitus. The blood viscosity is strongly correlated with aggregation of red blood cells. Some noninvasive methods for estimating the blood viscosity based on ultrasonic spectroscopy have been proposed. In these studies, substitution experiments using particles with a large diameter have been performed in general because control of the aggregation size is very difficult. This study is aimed at assessing the validity of the substitution experiments and proposing a compensation technique for use in the substitution experiments.
Extraction of Character Sequences from Signboards by Using Background Color Information
Authors: NOMURA MATSUNOBU , SUZUKI TAKUMA , KAGEYAMA YOICHI , ISHIZAWA CHIKAKO , NISHIDA MAKOTO
Published: July 2015

Smart phones, tablets, and mobile phones with built‐in cameras are very popular today because they are easy to use. It is important for image processors to be able to identify a signboard in an image and extract the character sequence. Techniques for extracting a character sequence from a signboard can be combined with various other systems to realize a diverse range of services. When utilization of such a system is assumed, it is necessary to take into consideration improvements in the accuracy of extraction of character sequence regions and improvements in processing speed. Therefore, this paper proposes an algorithm for extracting a character sequence from a signboard on the basis of scene image features. In order to improve the processing speed and accuracy, information about the background color of the signboard obtained in cooperation with a car navigation system or any other source was also utilized. In an experiment conducted on 319 color signboards, the proposed method detected 313 signboards (98.12%). Among 569 black and white signboards, the proposed method detected 513 signboards (90.16%). The average processing time in the proposed method was about 0.47 s for a color signboard and about 0.95 s for a black and white signboard. The experimental results revealed that the proposed method could accurately extract various types of character strings from signboards.
A risk-based approach to managing active pharmaceutical ingredients in manufacturing effluent
Authors: Caldwell Daniel J. , Mertens Birgit , Kappler Kelly , Senac Thomas , Journel Romain , Wilson Peter , Meyerhoff Roger D. , Parke Neil J. , Mastrocco Frank , Mattson Bengt , Murray-Smith Richard , Dolan David G. , Straub Jürg Oliver , Wiedemann Michael , Hartmann Andreas , Finan Douglas S.
Published: July 2015

The present study describes guidance intended to assist pharmaceutical manufacturers in assessing, mitigating, and managing the potential environmental impacts of active pharmaceutical ingredients (APIs) in wastewater from manufacturing operations, including those from external suppliers. The tools are not a substitute for compliance with local regulatory requirements but rather are intended to help manufacturers achieve the general standard of “no discharge of APIs in toxic amounts.” The approaches detailed in the present study identify practices for assessing potential environmental risks from APIs in manufacturing effluent and outline measures that can be used to reduce the risk, including selective application of available treatment technologies. These measures either are commonly employed within the industry or have been implemented to a more limited extent based on local circumstances. Much of the material is based on company experience and case studies discussed at an industry workshop held on this topic. Environ Toxicol Chem 2016;35:813–822. © 2015 The Authors. Environmental Toxicology and Chemistry Published by Wiley Periodicals, Inc. on behalf of SETAC.
A Halophila baillonis Ascherson bed on the semiarid coast of Brazil
Authors: Barros Kcrishna , Costa Francimeire , Rocha‐Barreira Cristina
Published: July 2015

The present study records Halophila baillonis and describes the specimens of the Environmental Protection Area of the Parnaíba River Delta, Piauí, semiarid coast of Brazil. In August 2014, we mapped and characterized the seagrass meadow, and georeferenced the extent of H. baillonis patches within the area. Ten ramets were collected manually for biometric measurements, and five samples were collected using a PVC corer of 10 cm in diameter, inserted at 15 cm depth, to obtain averages of shoot density and belowground/aboveground biomass ratios. Apart from H. baillonis, we recorded Halodule wrightii, Halodule sp. and Halophila decipiens, characterizing the seagrass meadow of Cajueiro da Praia as the most diverse on the Brazilian coast. Average density was between 96 and 1401 shoots m–2; total biomass ranged from 14.3 g dw m–2 to 27.1 g dw m–2; and leaf size 7.8 to 23.8 mm. In general, density, biometric and biomass values of the plants were greater than or at the upper range described in other areas, co‐occurring with other seagrass species and on a variety of sediments, indicating a well‐established bed. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
What Natural Gas and Electric Industry Must Know About OSHA
Authors: Snare Jonathan L. , Ladeau Rachel
Published: July 2015

In a recent memorandum to regional administrators, Occupational Safety and Health Administration (OSHA) Director of Enforcement Programs Thomas Galassi noted that worker fatality rates at upstream drilling and well servicing operations range from five to eight times greater than the national average for all US industries.
Should Colorado Methane Regulations Serve as Model for Federal Rules?
Authors: Rosen Julie A.
Published: July 2015

In February 2014, the Colorado Air Quality Control Commission adopted rules to directly regulate methane and volatile organic compounds (VOCs) emissions from oil and gas sources.
Co‐option of developmentally regulated plant SWEET transporters for pathogen nutrition and abiotic stress tolerance
Authors: Chandran Divya
Published: July 2015

Plant sugar will eventually be exported transporter (SWEET) sugar transporters have been implicated in various developmental processes where sugar efflux is essential, including sucrose loading of phloem for long‐distance sugar transport, nectar secretion, embryo and pollen nutrition, and maintenance of sugar homeostasis in plant organs. Notably, these transporters are selectively targeted by pathogens to gain access to host sugars. In most cases, when SWEET function is blocked, the growth and virulence of the pathogen is also reduced. There is growing evidence to suggest that the lifestyle of the pathogen may dictate which SWEET or set of SWEET genes are recruited for pathogen growth and proliferation. Furthermore, SWEET transporters may also play a role in abiotic stress tolerance by enabling plant growth under unfavorable environmental conditions. This review provides an overview of the diverse functions of SWEET proteins in plant development, pathogen nutrition, and abiotic stress tolerance. In addition, utility of the model legume Medicago truncatula as a tool to elucidate SWEET function in diverse host–microbe interactions is discussed. © 2015 IUBMB Life, 67(7):461–471, 2015
Defensive and adverse energy‐related molecular responses precede tris (1, 3‐dichloro‐2‐propyl) phosphate cytotoxicity
Authors: Zhang Jinkang , Williams Timothy D. , Chipman James K. , Viant Mark R.
Published: July 2015

To understand the potentially adverse effects of human exposure to tris (1, 3‐dichloro‐2‐propyl) phosphate (TDCIPP) and explore the underlying molecular mechanisms, combined transcriptomic and metabolomic approaches were employed to investigate the molecular responses of two human cell lines exposed to different concentrations of TDCIPP. Comparative analyses of transcriptional and metabolic profiles of HepG2/C3A and A549 cells were performed after exposure to 1, 10 and 100 μM TDCIPP for 24 and 72 h. Stress responses (e.g. xenobiotic metabolism and ABC transporter pathways) were observed at the transcriptional level after 24‐h exposure to a sub‐cytotoxic concentration (10 μM). Transcription of an energy metabolism‐related pathway (oxidative phosphorylation) was down‐regulated more severely at 100 μM TDCIPP exposure, accompanied by the suppression of pathways relevant to cell proliferation (e.g. cell cycle and DNA replication), while no significant cytotoxic effects were observed. Functional metabolic changes were observed after 72 h in HepG2/C3A cells exposed to 100 μM TDCIPP that corresponded to changes detected at the transcriptional level after 24 h. Taken together, defensive responses to chemical exposure and energy‐related changes both precede the cytotoxic effects of TDCIPP in HepG2/C3A cells. Copyright © 2015 John Wiley & Sons, Ltd.