bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S4 from Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation
Authors: Lin Timothy A. , McCaw Zachary R. , Koong Alex , Lin Christine , Abi Jaoude Joseph , Patel Roshal , Kouzy Ramez , El Alam Molly B. , Sherry Alexander D. , Noticewala Sonal S. , Fuller Clifton D. , Thomas Charles R. , Sun Ryan , Lee J. Jack , Lin Ruitao , Yuan Ying , Shyr Yu , Meirson Tomer , Ludmir Ethan B.
Published: October 2024

Figure S4 Scatter Plot of the negative natural logarithm of the p-values of the restricted mean survival time difference and the trial hazard ratio for all Kaplan-Meier comparisons in this study. Increasing values along the x-axis represent decreasing log-rank p-values, while increasing values along the y-axis represent decreasing RMST difference pvalues. Studies reporting a log-rank p-value or RMST difference p-value as an inequality (e.g., p-value <.001) were considered to have a p-value of 0.001 for the purposes of graphical representation on the graph and are represented by a cluster of points in the top right corner of the graph. The solid blue horizontal and vertical lines represent the x-value and y-values at which p = .05. The dashed black line represents a reference line with the equation y = x crossing through the origin. RMST-D, restricted mean survival time difference.
Supplementary Table S7 from Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial
Authors: Grivas Petros , Garralda Elena , Meric-Bernstam Funda , Mellinghoff Ingo K. , Goyal Lipika , Harding James J. , Dees E. Claire , Bahleda Rastislav , Azad Nilofer S. , Karippot Asha , Kurzrock Razelle , Tabernero Josep , Kononen Juha , Ng Matthew C.H. , Mehta Rutika , Uboha Nataliya V. , Bigot Frédéric , Boni Valentina , Bowyer Samantha E. , Breder Valeriy , Cervantes Andrés , Chan Nancy , Cleary James M. , Dhawan Mallika , Eefsen Rikke L. , Ewing James , Graham Donna M. , Guren Tormod K. , Won Kim Jin , Koynov Krassimir , Oh Do-Youn , Redman Rebecca , Yen Chia-Jui , Spetzler David , Roubaudi-Fraschini Marie-Claude , Nicolas-Metral Valerie , Ait-Sarkouh Rafik , Zanna Claudio , Ennaji Abdallah , Pokorska-Bocci Anna , Flaherty Keith T.
Published: October 2024

Supplementary Table S7. Progression-free survival according to central review (intention-to-treat population).
Supplementary Table S6 from Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial
Authors: Grivas Petros , Garralda Elena , Meric-Bernstam Funda , Mellinghoff Ingo K. , Goyal Lipika , Harding James J. , Dees E. Claire , Bahleda Rastislav , Azad Nilofer S. , Karippot Asha , Kurzrock Razelle , Tabernero Josep , Kononen Juha , Ng Matthew C.H. , Mehta Rutika , Uboha Nataliya V. , Bigot Frédéric , Boni Valentina , Bowyer Samantha E. , Breder Valeriy , Cervantes Andrés , Chan Nancy , Cleary James M. , Dhawan Mallika , Eefsen Rikke L. , Ewing James , Graham Donna M. , Guren Tormod K. , Won Kim Jin , Koynov Krassimir , Oh Do-Youn , Redman Rebecca , Yen Chia-Jui , Spetzler David , Roubaudi-Fraschini Marie-Claude , Nicolas-Metral Valerie , Ait-Sarkouh Rafik , Zanna Claudio , Ennaji Abdallah , Pokorska-Bocci Anna , Flaherty Keith T.
Published: October 2024

Supplementary Table S6. Response according to central review (modified intention-to-treat population).
Supplementary Table S2 from Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial
Authors: Grivas Petros , Garralda Elena , Meric-Bernstam Funda , Mellinghoff Ingo K. , Goyal Lipika , Harding James J. , Dees E. Claire , Bahleda Rastislav , Azad Nilofer S. , Karippot Asha , Kurzrock Razelle , Tabernero Josep , Kononen Juha , Ng Matthew C.H. , Mehta Rutika , Uboha Nataliya V. , Bigot Frédéric , Boni Valentina , Bowyer Samantha E. , Breder Valeriy , Cervantes Andrés , Chan Nancy , Cleary James M. , Dhawan Mallika , Eefsen Rikke L. , Ewing James , Graham Donna M. , Guren Tormod K. , Won Kim Jin , Koynov Krassimir , Oh Do-Youn , Redman Rebecca , Yen Chia-Jui , Spetzler David , Roubaudi-Fraschini Marie-Claude , Nicolas-Metral Valerie , Ait-Sarkouh Rafik , Zanna Claudio , Ennaji Abdallah , Pokorska-Bocci Anna , Flaherty Keith T.
Published: October 2024

Supplementary Table S2. Tissue source for FGFR fusion determination (intention-to-treat population).
Supplementary Data S2 from Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation
Authors: Lin Timothy A. , McCaw Zachary R. , Koong Alex , Lin Christine , Abi Jaoude Joseph , Patel Roshal , Kouzy Ramez , El Alam Molly B. , Sherry Alexander D. , Noticewala Sonal S. , Fuller Clifton D. , Thomas Charles R. , Sun Ryan , Lee J. Jack , Lin Ruitao , Yuan Ying , Shyr Yu , Meirson Tomer , Ludmir Ethan B.
Published: October 2024

Data Supplement S2: Reconstructed Kaplan-Meier graphs for trials exhibiting discordance between the trial result and RMST or MaxCombo-based analyses with proportional hazards violations (Section A) or without evidence of proportional hazards violations (Section B)
Supplementary Table S13 from Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial
Authors: Grivas Petros , Garralda Elena , Meric-Bernstam Funda , Mellinghoff Ingo K. , Goyal Lipika , Harding James J. , Dees E. Claire , Bahleda Rastislav , Azad Nilofer S. , Karippot Asha , Kurzrock Razelle , Tabernero Josep , Kononen Juha , Ng Matthew C.H. , Mehta Rutika , Uboha Nataliya V. , Bigot Frédéric , Boni Valentina , Bowyer Samantha E. , Breder Valeriy , Cervantes Andrés , Chan Nancy , Cleary James M. , Dhawan Mallika , Eefsen Rikke L. , Ewing James , Graham Donna M. , Guren Tormod K. , Won Kim Jin , Koynov Krassimir , Oh Do-Youn , Redman Rebecca , Yen Chia-Jui , Spetzler David , Roubaudi-Fraschini Marie-Claude , Nicolas-Metral Valerie , Ait-Sarkouh Rafik , Zanna Claudio , Ennaji Abdallah , Pokorska-Bocci Anna , Flaherty Keith T.
Published: October 2024

Supplementary Table S13. Serious adverse events occurring in ≥2 patients (safety population).
Supplementary Table S2 from Clinical and Molecular Risk Factors in Extracranial Malignant Rhabdoid Tumors: Toward an Integrated Model of High-Risk Tumors
Authors: Fincke Victoria E. , Steinbügl Mona , Chun Hye-Jung E. , Nemes Karolina , Mucha Marlena , Loßner Maurice , Dorn Felix , Gastberger Katharina , Bühner Sebastian , Sill Martin , Kröncke Thomas , Siebert Reiner , Melchior Patrick , Furtwängler Rhoikos , Schlesner Matthias , Vokuhl Christian , Röcken Christoph , Johann Pascal D. , Frühwald Michael C.
Published: October 2024

Results of differential gene expression analysis
Supplementary Methods S1 from Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial
Authors: Grivas Petros , Garralda Elena , Meric-Bernstam Funda , Mellinghoff Ingo K. , Goyal Lipika , Harding James J. , Dees E. Claire , Bahleda Rastislav , Azad Nilofer S. , Karippot Asha , Kurzrock Razelle , Tabernero Josep , Kononen Juha , Ng Matthew C.H. , Mehta Rutika , Uboha Nataliya V. , Bigot Frédéric , Boni Valentina , Bowyer Samantha E. , Breder Valeriy , Cervantes Andrés , Chan Nancy , Cleary James M. , Dhawan Mallika , Eefsen Rikke L. , Ewing James , Graham Donna M. , Guren Tormod K. , Won Kim Jin , Koynov Krassimir , Oh Do-Youn , Redman Rebecca , Yen Chia-Jui , Spetzler David , Roubaudi-Fraschini Marie-Claude , Nicolas-Metral Valerie , Ait-Sarkouh Rafik , Zanna Claudio , Ennaji Abdallah , Pokorska-Bocci Anna , Flaherty Keith T.
Published: October 2024

Supplementary methods
Supplementary Figure S2 from Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial
Authors: Grivas Petros , Garralda Elena , Meric-Bernstam Funda , Mellinghoff Ingo K. , Goyal Lipika , Harding James J. , Dees E. Claire , Bahleda Rastislav , Azad Nilofer S. , Karippot Asha , Kurzrock Razelle , Tabernero Josep , Kononen Juha , Ng Matthew C.H. , Mehta Rutika , Uboha Nataliya V. , Bigot Frédéric , Boni Valentina , Bowyer Samantha E. , Breder Valeriy , Cervantes Andrés , Chan Nancy , Cleary James M. , Dhawan Mallika , Eefsen Rikke L. , Ewing James , Graham Donna M. , Guren Tormod K. , Won Kim Jin , Koynov Krassimir , Oh Do-Youn , Redman Rebecca , Yen Chia-Jui , Spetzler David , Roubaudi-Fraschini Marie-Claude , Nicolas-Metral Valerie , Ait-Sarkouh Rafik , Zanna Claudio , Ennaji Abdallah , Pokorska-Bocci Anna , Flaherty Keith T.
Published: October 2024

Supplementary Figure S2. Progression-free survival.
Supplementary Figure S1 from Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial
Authors: Grivas Petros , Garralda Elena , Meric-Bernstam Funda , Mellinghoff Ingo K. , Goyal Lipika , Harding James J. , Dees E. Claire , Bahleda Rastislav , Azad Nilofer S. , Karippot Asha , Kurzrock Razelle , Tabernero Josep , Kononen Juha , Ng Matthew C.H. , Mehta Rutika , Uboha Nataliya V. , Bigot Frédéric , Boni Valentina , Bowyer Samantha E. , Breder Valeriy , Cervantes Andrés , Chan Nancy , Cleary James M. , Dhawan Mallika , Eefsen Rikke L. , Ewing James , Graham Donna M. , Guren Tormod K. , Won Kim Jin , Koynov Krassimir , Oh Do-Youn , Redman Rebecca , Yen Chia-Jui , Spetzler David , Roubaudi-Fraschini Marie-Claude , Nicolas-Metral Valerie , Ait-Sarkouh Rafik , Zanna Claudio , Ennaji Abdallah , Pokorska-Bocci Anna , Flaherty Keith T.
Published: October 2024

Supplementary Figure S1. Study CONSORT diagram.
Supplementary Figure S4 from Clinical and Molecular Risk Factors in Extracranial Malignant Rhabdoid Tumors: Toward an Integrated Model of High-Risk Tumors
Authors: Fincke Victoria E. , Steinbügl Mona , Chun Hye-Jung E. , Nemes Karolina , Mucha Marlena , Loßner Maurice , Dorn Felix , Gastberger Katharina , Bühner Sebastian , Sill Martin , Kröncke Thomas , Siebert Reiner , Melchior Patrick , Furtwängler Rhoikos , Schlesner Matthias , Vokuhl Christian , Röcken Christoph , Johann Pascal D. , Frühwald Michael C.
Published: October 2024

Supplementary Figure 4: Mean methylation of the primary and relapsed or refractory tumors for five patients.
Supplementary Table S5 from Transcriptomic Heterogeneity of EGFR-Mutant Non–Small Cell Lung Cancer Evolution Toward Small-Cell Lung Cancer
Authors: Oh Songji , Koh Jaemoon , Kim Tae Min , Kim Soyeon , Youk Jeonghwan , Kim Miso , Keam Bhumsuk , Jeon Yoon Kyung , Ku Ja-Lok , Kim Dong-Wan , Chung Doo Hyun , Heo Dae Seog
Published: October 2024

Supplementary Table S5. Reactome pathway analysis of DEGs in EGFR-mutant LADC and SCLC. Negative values of the normalized enrichment score indicate pathway enrichment in t-SCLC.
Supplementary Table S3 from Transcriptomic Heterogeneity of EGFR-Mutant Non–Small Cell Lung Cancer Evolution Toward Small-Cell Lung Cancer
Authors: Oh Songji , Koh Jaemoon , Kim Tae Min , Kim Soyeon , Youk Jeonghwan , Kim Miso , Keam Bhumsuk , Jeon Yoon Kyung , Ku Ja-Lok , Kim Dong-Wan , Chung Doo Hyun , Heo Dae Seog
Published: October 2024

Supplementary Table S3. Summarization of the dominant SCLC subtypes.
Supplementary Table S2 from Transcriptomic Heterogeneity of EGFR-Mutant Non–Small Cell Lung Cancer Evolution Toward Small-Cell Lung Cancer
Authors: Oh Songji , Koh Jaemoon , Kim Tae Min , Kim Soyeon , Youk Jeonghwan , Kim Miso , Keam Bhumsuk , Jeon Yoon Kyung , Ku Ja-Lok , Kim Dong-Wan , Chung Doo Hyun , Heo Dae Seog
Published: October 2024

Supplementary Table S2. Annotation template file.
Supplementary Table S1 from Transcriptomic Heterogeneity of EGFR-Mutant Non–Small Cell Lung Cancer Evolution Toward Small-Cell Lung Cancer
Authors: Oh Songji , Koh Jaemoon , Kim Tae Min , Kim Soyeon , Youk Jeonghwan , Kim Miso , Keam Bhumsuk , Jeon Yoon Kyung , Ku Ja-Lok , Kim Dong-Wan , Chung Doo Hyun , Heo Dae Seog
Published: October 2024

Supplementary Table S1. Clinicopathologic characteristics of 11 patients transformed from lung adenocarcinoma to small cell lung cancer.
Supplementary Figure S3 from Transcriptomic Heterogeneity of EGFR-Mutant Non–Small Cell Lung Cancer Evolution Toward Small-Cell Lung Cancer
Authors: Oh Songji , Koh Jaemoon , Kim Tae Min , Kim Soyeon , Youk Jeonghwan , Kim Miso , Keam Bhumsuk , Jeon Yoon Kyung , Ku Ja-Lok , Kim Dong-Wan , Chung Doo Hyun , Heo Dae Seog
Published: October 2024

Supplementary Figure S3. Genes altered during the transition to t-SCLC.
Supplementary Figure S2 from Transcriptomic Heterogeneity of EGFR-Mutant Non–Small Cell Lung Cancer Evolution Toward Small-Cell Lung Cancer
Authors: Oh Songji , Koh Jaemoon , Kim Tae Min , Kim Soyeon , Youk Jeonghwan , Kim Miso , Keam Bhumsuk , Jeon Yoon Kyung , Ku Ja-Lok , Kim Dong-Wan , Chung Doo Hyun , Heo Dae Seog
Published: October 2024

Supplementary Figure S2. Clinical history of LC3 to LC11.
Supplementary Figures 1 from HER2 Antibody–Drug Conjugates Are Active against Desmoplastic Small Round Cell Tumor
Authors: Zhang Tom , Febres-Aldana Christopher A. , Liu Zebing , Dix Jenna-Marie , Cheng Ryan , Dematteo Raymond G. , Lui Allan J.W. , Khodos Inna , Gili Leo , Mattar Marissa S. , Lisanti Jeanine , Kwong Charlene , Linkov Irina , Tipping Murray J. , de Stanchina Elisa , Odintsov Igor , Ladanyi Marc , Somwar Romel
Published: October 2024

Figures S1-S11
Supplementary Figure S9 from Tumor-Secreted Extracellular Vesicles Counteract Therapy Response by Triggering Inflammatory Mesenchymal Stem Cell Development
Authors: Massaro Crescenzo , Sensoy Hilal N. , Mulders Manon , De Schrijver Celine , Gómez-Martín Cristina , Simon Nieto Juan , Lagerweij Tonny , Atmopawiro Alisha , Pérez-Boza Jennifer , Bebelman Maarten , Bosch Leontien , Foderaro Simone , Neves Ferreira Mafalda , van Eijndhoven Monique A.J. , van Weering Jan R.T. , Dell’Aversana Carmela , Altucci Lucia , Savci-Heijink Cemile Dilara , van de Donk Niels W.C.J. , Giorgio Cristina , Brandolini Laura , Allegretti Marcello , Pegtel Dirk Michiel , Baglio Serena Rubina
Published: October 2024

Suppl. Figure 9. a) BLI images of tumor-bearing mice receiving Ladarixin and injected or not with human EV-induced iMSCs. b-c) Tumor growth measured by caliper (b) and lung nodules count (c) in tumor-bearing mice receiving ladarixin in combination with EW-7197 (TGFBR1 inhibitor) and injected or not with human EV-induced iMSCs.
Data from A Phase Ib/II Randomized Clinical Trial of Oleclumab with or without Durvalumab plus Chemotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma
Authors: Coveler Andrew L. , Reilley Matthew J. , Zalupski Mark , Macarulla Teresa , Fountzilas Christos , Ponz-Sarvisé Mariano , Nagrial Adnan , Uboha Nataliya V. , Frentzas Sophia , Overman Michael , Noonan Anne , Messersmith Wells A. , Pavlakis Nick , Mettu Niharika B. , Bisha Ina , Wang Ying , Smith Paul , Murtomaki Elina , Bielska Agata A. , Bragulat Veronique , Cooper Zachary A. , Kumar Rakesh , Spigel David R.
Published: October 2024

AbstractPurpose:
Pancreatic ductal adenocarcinoma upregulates CD73, potentially contributing to immune surveillance evasion. Combining oleclumab (CD73 inhibitor) and durvalumab with chemotherapy may identify an effective treatment option.
Patients and Methods:
We describe a multicenter phase Ib/II randomized clinical trial in patients with metastatic pancreatic ductal adenocarcinoma, untreated (cohort A) or previously received gemcitabine-based chemotherapy (cohort B; NCT03611556). During escalation, patients received oleclumab 1,500 or 3,000 mg, durvalumab 1,500 mg, and gemcitabine plus nab-paclitaxel (GnP; cohort A; n = 14) or modified FOLFOX (cohort B; n = 11). During expansion, cohort A patients (n = 170) were randomized to GnP (arm A1), oleclumab [recommended phase II dose (RP2D)] with GnP (arm A2), or oleclumab (RP2D) with durvalumab plus GnP (arm A3). Primary objectives were safety (escalation) and objective response rate (expansion). Secondary objectives included progression-free survival (PFS) and overall survival (OS).
Results:
During escalation, 1/11 patients from cohort B (oleclumab 3,000 mg) experienced two dose-limiting toxicities. Oleclumab’s RP2D was 3,000 mg. During expansion, grade ≥3 treatment-related adverse events occurred in 67.7% (42/62) of patients in A1, 73.7% (28/38) in A2, and 77.1% (54/70) in A3. The objective response rate was 29.0%, 21.1%, and 32.9% in A1, A2, and A3, respectively (A1 vs. A3; P = 0.650). PFS [HR = 0.72; 95% confidence interval (CI), 0.47, 1.11] and OS (HR = 0.75; 95% CI, 0.50–1.13) were similar for A3 versus A1. Patients with high CD73 expression had improved PFS and OS in A3 versus A1, although this should be interpreted with caution.
Conclusions:
Although the safety profile was acceptable, this study did not meet its primary efficacy endpoint.
Data from Metabolomic Prediction of Breast Cancer Treatment–Induced Neurologic and Metabolic Toxicities
Authors: Piffoux Max , Jacquemin Jérémie , Pétéra Mélanie , Durand Stéphanie , Abila Angélique , Centeno Delphine , Joly Charlotte , Lyan Bernard , Martin Anne-Laure , Everhard Sibille , Boyault Sandrine , Pistilli Barbara , Fournier Marion , Rouanet Philippe , Havas Julie , Sauterey Baptiste , Campone Mario , Tarpin Carole , Mouret-Reynier Marie-Ange , Rigal Olivier , Petit Thierry , Lasset Christine , Bertaut Aurélie , Cottu Paul , André Fabrice , Vaz-Luis Ines , Pujos-Guillot Estelle , Drouet Youenn , Trédan Olivier
Published: October 2024

AbstractPurpose:
Long-term treatment-related toxicities, such as neurologic and metabolic toxicities, are major issues in breast cancer. We investigated the interest of metabolomic profiling to predict toxicities.
Experimental Design:
Untargeted high-resolution metabolomic profiles of 992 patients with estrogen receptor (ER)+/HER2− breast cancer from the prospective CANTO cohort were acquired (n = 1935 metabolites). A residual-based modeling strategy with discovery and validation cohorts was used to benchmark machine learning algorithms, taking into account confounding variables.
Results:
Adaptive Least Absolute Shrinkage and Selection (adaptive LASSO) has a good predictive performance, has limited optimism bias, and allows the selection of metabolites of interest for future translational research. The addition of low-frequency metabolites and nonannotated metabolites increases the predictive power. Metabolomics adds extra performance to clinical variables to predict various neurologic and metabolic toxicity profiles.
Conclusions:
Untargeted high-resolution metabolomics allows better toxicity prediction by considering environmental exposure, metabolites linked to microbiota, and low-frequency metabolites.
Data from Clinical and Molecular Risk Factors in Extracranial Malignant Rhabdoid Tumors: Toward an Integrated Model of High-Risk Tumors
Authors: Fincke Victoria E. , Steinbügl Mona , Chun Hye-Jung E. , Nemes Karolina , Mucha Marlena , Loßner Maurice , Dorn Felix , Gastberger Katharina , Bühner Sebastian , Sill Martin , Kröncke Thomas , Siebert Reiner , Melchior Patrick , Furtwängler Rhoikos , Schlesner Matthias , Vokuhl Christian , Röcken Christoph , Johann Pascal D. , Frühwald Michael C.
Published: October 2024

AbstractPurpose:
Extracranial malignant rhabdoid tumors (eMRT) are a challenging entity. Despite the use of multimodal treatment approaches, therapy failure occurs in 55% to 67% of these. Molecular markers for identification of patients at increased risk for relapse or refractory (R/R) disease are not available. Clinical characteristics may only insufficiently predict the individual course of disease.
Experimental Design:
Using the EU-RHAB database, we analyzed a cohort of 121 patients with eMRT clinically. For 81 patients, molecular and clinical data were available, which were further complemented with publicly available DNA molecular data from 92 eMRTs. We aimed to delineate molecular risk factors by dissecting the DNA methylome of these tumors. Moreover, we establish clinical characteristics and treatment details of R/R disease in a subcohort of 80 patients.
Results:
Using consensus hierarchical clustering, we identified three distinct subgroups, one of which (eMRT standard risk) was associated with significantly improved survival, irrespective of germline status and/or localization. At the transcriptome level, this subgroup was characterized by an overexpression of genes involved in muscle development. A relevant proportion of patients developed distant relapses or progressions; the median time to the event was 4 months, underlining the need for early identification and risk stratification of R/R disease. The overall survival was significantly decreased in patients with progressive disease when compared with relapse cases, and reaching complete remission during salvage therapy provided a survival benefit.
Conclusions:
Our analysis of eMRT in this comprehensive cohort provides novel insights into the patterns of relapse and integrates molecular and clinical risk factors to guide clinical decision-making.
Figure S6 from Oncogenic Mutant p53 Sensitizes Non–Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress–Dependent Induction of Mitochondrial Apoptosis
Authors: Chougoni Kranthi Kumar , Neely Victoria , Ding Boxiao , Oduah Eziafa , Lam Vianna T. , Hu Bin , Koblinski Jennifer E. , Windle Bradford E. , Palit Deb Swati , Deb Sumitra , Nieva Jorge J. , Radhakrishnan Senthil K. , Harada Hisashi , Grossman Steven R.
Published: October 2024

Figure S6
Figure 4 from Oncogenic Mutant p53 Sensitizes Non–Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress–Dependent Induction of Mitochondrial Apoptosis
Authors: Chougoni Kranthi Kumar , Neely Victoria , Ding Boxiao , Oduah Eziafa , Lam Vianna T. , Hu Bin , Koblinski Jennifer E. , Windle Bradford E. , Palit Deb Swati , Deb Sumitra , Nieva Jorge J. , Radhakrishnan Senthil K. , Harada Hisashi , Grossman Steven R.
Published: October 2024

The Onc-p53–NRF2–ATF3–NOXA pathway contributes to BTZ-induced apoptosis in Onc-p53 NSCLC cells. A, H1975 cells were treated with vehicle or BTZ (10 nmol/L) ± NAC (1 mmol/L) for 24 hours, and confocal immunofluorescence microscopy was performed using NRF2 antibody (red) and DAPI to highlight nuclei (blue). Representative individual and merged images (40× magnification) of NRF2 and DAPI stains are shown. B, H1975 cells were treated with vehicle, BTZ, or BTZ + NAC, followed by NRF2 and DAPI staining as in A and fluorescence microscopy. The percentage of cells with NRF2 localization exclusive to the nucleus was determined from 10 random fields (>10 cells/field counted) at 20× magnification. A pairwise comparison was made using the Student t test between the two groups. C, H1975 cells were treated with vehicle, NAC (1 mmol/L), BTZ (5 nmol/L), or BTZ + NAC for 48 hours, and cell lysates were immunoblotted with NRF2 and GAPDH antibodies. D, H1975 cells stably expressing control shRNA (shC) or NRF2 shRNA (shNRF2) were treated with vehicle or BTZ (5 nmol/L) for 48 hours, and cell lysates were immunoblotted with indicated antibodies. E, H1975 shC and shNRF2 cells were treated with vehicle or the indicated concentrations of BTZ for 72 hours, and cell viability was determined by WST-1 assay. F, H1975-Control or H1975-p53KO cells were treated with vehicle (−) or BTZ (5 nmol/L) for 48 hours, followed by immunoblotting of cell lysates with indicated antibodies. **, P < 0.01; ***, P < 0.001. Error bars indicate ± 1.0 SD.
Type 1 Diabetes: Associations Between Lifestyle Factors and Overweight and Obesity in Under 19-Year-Olds
Authors: Hill Alyson
Published: October 2024

This review aims to identify and report epidemiological associations between modifiable lifestyle risk factors for overweight or obesity in children and adolescents with type 1 diabetes (T1D). A systematic literature search of medical databases from 1990 to 2023 was undertaken. Inclusion criteria were observational studies reporting on associations between dietary factors, disordered eating, physical activity, sedentary and sleep behaviours and measures of adiposity in children and adolescents (<18 years) with T1D. Thirty-seven studies met inclusion criteria. Studies were mostly cross-sectional (89 %), and 13 studies included adolescents up to 19 years which were included in this analysis. In adolescents with T1D, higher adiposity was positively associated with disordered eating behaviours (DEB) and a higher than recommended total fat and lower carbohydrate intake. A small amount of evidence suggested a positive association with skipping meals, and negative associations with diet quality and sleep stage. There were no published associations between overweight and physical activity, sedentary behaviours and eating disorders. Overall, the findings infer relationships between DEB, fat and carbohydrate intake and adiposity outcomes in people with T1D. Prospective studies are needed to determine causal relationships and to investigate sleep stages. High quality studies objectively measuring physical activity and include body composition outcomes are needed.
The Dietitian’s Role in the Management in Neuroblastoma in Children
Authors: McCullough Fiona
Published: October 2024

The ketogenic diet (KD) was initially used in 1920 for drug-resistant epileptic patients. From this point onward, ketogenic diets became a pivotal part of nutritional therapy research. To date, KD has shown therapeutic potential in many pathologies such as Alzheimer's disease, Parkinson's disease, autism, brain cancers, and multiple sclerosis. Although KD is now an adjuvant therapy for certain diseases, its effectiveness as an antitumor nutritional therapy is still an ongoing debate, especially in Neuroblastoma. Neuroblastoma is the most common extra-cranial solid tumour in children and is metastatic at initial presentation in more than half of the cases. Although Neuroblastoma can be managed by surgery, chemotherapy, immunotherapy, and radiotherapy, its 5-year survival rate in children remains below 40%. Earlier studies have proposed the ketogenic diet as a possible adjuvant therapy for patients undergoing treatment for Neuroblastoma. In this study, we seek to review the possible roles of KD in the treatment of Neuroblastoma.
Effective Management of Short Bowel Syndrome with a Restricted Oral Diet and Parenteral Nutrition: A Case Report
Authors: Karayiannis Dimitrios
Published: October 2024

A restricted oral diet can play a pivotal role in the nutritional management of patients with short bowel syndrome (SBS), particularly those with high-output stomas. These patients, especially if they have less than 100 cm of residual small bowel, are at increased risk of dehydration, electrolyte imbalances, and malnutrition due to excessive loss of fluids and nutrients. In this report, we describe the case of a 56-year-old male patient with 90 cm of remaining small bowel, no colon in continuity, and a high-output stoma. Despite significant challenges, the patient was successfully managed through a restricted oral diet in conjunction with parenteral nutrition (PN), medications, and high compliance to the therapeutic regimen. Over several months, stoma output decreased, and the patient’s nutritional status improved, leading to weight stabilization and enhanced physical strength. Upon discharge, the patient was able to maintain an oral diet supplemented with parenteral saline and experienced a significant improvement in quality of life. This case demonstrates that the combined approach of restricted oral intake, PN, pharmacological treatment, and patient adherence can effectively manage SBS patients with high-output stomas and less than 100 cm of bowel.
Save the Future: Climate Change is a Threat to Child Health and Nutrition
Authors: Dikmen Derya
Published: October 2024

Background: Children are more vulnerable than adults to climate-related health threats, but reviews examining how climate change affects human health have been mainly descriptive and lack an assessment of the magnitude of health effects children face. This is the first systematic review and meta-analysis that identifies which climate health relationships pose the greatest threats to children. Objectives: We reviewed epidemiologic studies to analyse various child health outcomes due to climate change and identify the relationships with the largest effect size. We identify population-specific risks and provide recommendations for future research. Methods: We searched four large online databases for observational studies published up to 5 January 2023 following PRISMA (systematic review) guidelines. We evaluated each included study individually and aggregated relevant quantitative data. We used quantitative data in our meta-analysis, where we standardised effect sizes and compared them among different groupings of climate variables and health outcomes.
Recent advancements in the field of Relative Energy Deficiency in Sport (REDs)
Authors: Janiszewska Katarzyna
Published: October 2024

Relative Energy Deficiency in Sport (REDs) was first introduced in 2014 by the International Olympic Committee’s expert writing panel, identifying a syndrome of deleterious health and performance outcomes experienced by female and male athletes exposed to low energy availability (LEA; inadequate energy intake in relation to exercise energy expenditure). Since the 2018 REDs consensus, there have been >170 original research publications advancing the field of REDs science, including emerging data demonstrating the growing role of low carbohydrate availability, further evidence of the interplay between mental health and REDs and more data elucidating the impact of LEA in males. Our knowledge of REDs signs and symptoms has resulted in updated Health and Performance Conceptual Models and the development of a novel Physiological Model. This Physiological Model is designed to demonstrate the complexity of either problematic or adaptable LEA exposure, coupled with individual moderating factors, leading to changes in health and performance outcomes. Guidelines for safe and effective body composition assessment to help prevent REDs are also outlined. A new REDs Clinical Assessment Tool-Version 2 is introduced to facilitate the detection and clinical diagnosis of REDs based on accumulated severity and risk stratification, with associated training and competition recommendations. Prevention and treatment principles of REDs are presented to encourage best practices for sports organisations and clinicians.Finally, methodological best practices for REDs research are outlined to stimulate future high-quality research to address important knowledge gaps. Reproduced from 2023 International Olympic Committee’s (IOC) consensus statement on Relative Energy Deficiency in Sport (REDs).
Experiences of Pregnant Women Undergoing Prenatal Gentle Yoga at Griya Kamini Gianyar
Authors: Dharma I Dewa Gede Candra , Citrawati Ni Ketut
Published: October 2024

During pregnancy, most women experience psychological and emotional changes, and it is not uncommon for a mother to feel worried about potential problems. Concerns may include the possibility of losing her beauty or the baby being abnormal. Prenatal gentle yoga, a modification of prenatal yoga with a gentle birth approach, is offered at Griya Kamini Gianyar. This practice involves deep yoga therapy to support a healthy and fit pregnancy and labor. This study aimed to understand the experiences of pregnant mothers undergoing Prenatal Gentle Yoga at Griya Kamini Gianyar.
The research design used in this study employs a qualitative interpretative method to understand the real experiences of pregnant women undergoing Prenatal Gentle Yoga Therapy at Griya Kamini Gianyar. The research results identified seven major themes: Positive Anticipation, Stress Management, Hope for Socializing, Connecting with Babies, Fitness and Flexibility, Professional Instructor Attitudes, and Managing Pain and Discomfort.
The overarching theme identified is Stress Management, indicating that Prenatal Gentle Yoga is practiced by pregnant mothers to manage their emotions and ensure a smooth birth. Overall, yoga can be a valuable tool for pregnant mothers to manage pain and discomfort. With a careful and thoughtful approach, yoga can help pregnant mothers experience a more comfortable pregnancy, both physically and mentally.
Causers, Causes, and Doers
Authors: Bianchi Robin T.
Published: October 2024

The view that to act is to cause change and that to be an agent is to be the causer of an action’s result has gained traction in the past twenty years or so. This view seems to have two significant corollaries. First, there is no distinction between doing an action and causing its result. Second, any two actions that have the same result will turn out to be identical. Ruben (2018) has recently used the first corollary to challenge the view, and the second corollary raises further problems for the view. This article aims to refine this view and defend it against the challenges that arise out of its two corollaries. It is argued that being the cause of an action’s result is not the same as being its causer and that doing an action is not just causing its result but causing it in a specific way.
Determinants of human-elephant conflict in tropical forest of South India
Authors: Ashokkumar Moharangan , Sakthivel Chinnaiyan , Sudhakar Kaliyaperumal
Published: October 2024

Human-elephant conflict (HEC) is a global conservation issue that undermines the conservation of an endangered species. HEC and the factors influencing crop-raiding behaviour were studied in the tropical forests of south India from Nov 2006 to Mar 2008. Crop depredation, protection methods, and land use changes were studied at Mudumalai Tiger Reserve (TR). A total of 297 incidents of crop damage were recorded, with peaks in the raiding during the monsoon season. Spatial analysis of HEC showed peripheral farms are more vulnerable (1.51%) than village centers (0.18%). Temporally, cropping patterns have changed from food crops to commercial crops. The elephant-damaged area was positively correlated with the effective perimeter (pe-rimeter with crops), total cultivated area, and area of degradation around the village. Logistic regression of crop raiding incidence with independent predictors showed that the incidence of raiding was 95% greater in moist deciduous forests than in thorny forests. Palatable crops were likely to be raided more frequently (391 times). Crops with protection methods were 22 times less likely to be targets of raids. In the areas adjacent to the Mudumalai TR, crop species, improvements in protection, and land use change reduced the HEC. Relocating villages from the core reserve and existing corridors in the eastern region is essential for conserving elephants in the Nilgiris, Western Ghats landscape.
Variation in Seedling Quality Attributes of Lentil (Lens culinaris Medik.) After Harvested Under Different Sowing Dates
Authors: Anteneh Melkam , Fikre Asnake , Feyissa Tileye
Published: October 2024

Planting dates are the most important components for Lentil seedling growth and development. Seeds planted in diverse environmental situations lead to changes in various seedling development and the final output of the yield. The present study, aimed to assess the effect of different planting (sowing) dates harvested seeds on the physiological properties of nineteen (19) lentil genotypes. Lentil was growing during two consecutive planting days on average the normal (main) 17/08/2021 and lately 16/09/2021, then harvested seed extract after five months of storage, planted CRD with two factorial designs and three replications under laboratory condition within a white plastic container filled with autoclaved 3.0kg sand applying 100ml distilled water. The lentil was grown per standard, and the lentil's postharvest physiological quality parameters were evaluated. Results indicated that the lowest speed of germination index was obtained during late planting time or stress situations on the genotype Adda (8.78) and ILL-1760 (8.94). Seedling length is the seedling vigor criterion and is statistically significantly different between planting dates at 1%. The effect of planting day on seedling fresh weight was significantly different (p < 0.01) on genotype Beredu (0.0022) on the main planting day. The seed viability on vigor index (II) as shown in was affected by planting date (p < 0.01) and genotypes (p < 0.01). The heritability value of shoot length, root length, and seedling fresh weight equal zero was the variation due to environmental it had no genetic effect after five months of storage both main and late planting. The seedling vigor index, fresh and dry weight traits maximum on the main planting day on the genotype Beredu indicates 0.0445, 0.00218, and 0.00045 respectively. Seeds from the main planting day had the best seedling traits performance and recorded minimal germination time compared to late planting seeds. Lentil seeds planted lately finally recorded lower seedling fresh and dry weight, vigor, and speed of germination index as compared to those harvested lentil seeds in main planting dates. As a result, when there is adequate rainfall necessary for lentil growth, development, and final output.
Factors Influencing the Adoption of Urban Agriculture and Its Effects on Household Food Security in Southwestern Nigeria
Authors: Oyebanji Akinsola
Published: October 2024

Given Nigeria's growing population and the rapid rural-to-urban migration, it is crucial to examine various initiatives that can consistently support and improve food security in urban areas. This study examined one of these initiatives, which has proven to be an effective strategy in some areas of the world. Factors influencing the adoption of urban agriculture and its effect on the food security of households were examined in this study. A multi-stage sampling technique was used for data collection among 325 respondents. The analysis was conducted using descriptive statistics, probit, and ordered probit regression models. The descriptive statistics revealed that about 59% of respondents are engaged in urban agriculture. Among the determinants of urban agriculture adoption, age, land ownership, land size, and association membership were observed to positively determine the adoption of urban agriculture, while years of education, access to credit, and income negatively influence its adoption. The ordered probit regression model was used to assess the factors that influence the food security of farming households. Covariates including age and household sizes were found to negatively influence food security. Conversely, gender, education, land ownership rights, land size, credit access, association membership, and urban agriculture positively influence household food security. It was therefore concluded that urban agriculture is an effective means to improve household food security in Southwestern Nigeria. However, increasing awareness and education about the benefits of urban agriculture is crucial, as people often abandon this practice when they have increased access to credit and income. Furthermore, policies toward promoting land ownership and equality in access to resources should be implemented, as this will promote easy participation in urban agriculture.
Analysis of Demographic Characteristics and Drinking Habits at a Southern College Provide Critical Information for Developing an Effective Prevention Program
Authors: Toland Rebecca M. , Rowan Tiera , Caballero Ivanna , Truong Dawn
Published: October 2024

Importance

To examine the associations of basic demographics (age, race, and gender identity) on alcohol consumption among college students at a mid-sized university.

Objective

To evaluate the drinking habits of students using the survey tool that will measure basic demographics to collect data.

Design

A cross-sectional study that included college students ages 17-21 at Columbus State University in the fall of 2021.

Setting

Columbus, Georgia.

Participants

University students (n = 260, mean age 20.5 ± 3.8).

Analysis

One-way ANOVA and independent t-tests were used to test differences in age on alcohol consumption and binge drinking. Chi-Square tests and Fisher’s Exact were used to estimate differences in proportions of binge drinking for race and gender.

Results

Underage students (57.7%) reported having consumed alcohol in the past. Frequency of alcohol consumption increased with age ( P = 0.004). Caucasian students reported drinking most frequently, with 14.8% (n = 12) drinking at least once a week, compared to 0 African American students reporting they drank at least once per week ( P < 0.001). There were no significant findings when examining differences in binge drinking for demographics assessed in this sample ( P > 0.05).

Conclusion

and Relevance: In this cross-sectional research study, the prevalence of underage drinking among college-aged students, there is a need for targeted prevention methods to reduce adverse health outcomes among this vulnerable population.
Assessing the stability of daptomycin in icodextrin-based peritoneal dialysis solution
Authors: Suzuki Hiroyuki , Kudo Kasumi , Uno Takashi , Konno Taisuke , Okada Kouji , Agatsuma Yasuyuki , Nakamura Hitoshi , Murai Yuriko
Published: October 2024

Background

The stability of antimicrobials in peritonitis during peritoneal dialysis (PD) solutions is a critical factor influencing treatment success. This study investigated the stability of daptomycin (DAP) when combined with icodextrin-based PD solution, by measuring DAP concentrations and observing any structural changes.

Methods

A dose of DAP (350 mg) was dissolved in 7 mL of saline in a clean bench. The solution was then injected into the large compartment (1,260 mL) of NICOPELIQ® Peritoneal Dialysis Solution and thoroughly mixed. Samples were collected at intervals ranging from 0 to 336 h (7 points in total). The concentration of DAP was quantified using high-performance liquid chromatography (HPLC). The structure of any unidentified peaks was determined using HPLC coupled with electrospray ionization tandem mass spectrometry.

Results

DAP maintained 90% of the initial concentration in NICOPELIC® for 72 h at room temperature and 12 h at 37 °C. Unidentified peaks, distinct from DAP, were detected during analysis. Further investigation indicated that these peaks corresponded to anhydrated DAP.

Conclusions

The findings from this stability study are expected to enhance the effectiveness of outpatient management and preparation for treating peritonitis using DAP.
A high-precision data-driven radar modeling method for autonomous driving simulations testing
Authors: Huang Kaibo , Deng Weiwen , Zhao Rui , Wang Ying , Ding Juan , Yang Yanzhao
Published: October 2024

Autonomous driving represents the future of transportation, and simulation testing is a critical technology for ensuring the safety and reliability of autonomous driving. In simulation systems, a real-time and accurate radar model is crucial for enhancing the confidence of autonomous driving simulation systems. Existing radar models are typically simplistic and cannot accurately reflect the detection results of real radars. This paper introduces a data-driven radar modeling method that analyzes radar detection mechanisms to identify the model’s input parameters. Furthermore, this method decouples the model’s output parameters based on the differing mechanisms of radar output parameters and tailors model structures to align with the mechanistic characteristics of each parameter. Subsequently, considering the varied influences among input parameters, a segmented model structure is proposed that reduces input dimensionality while retaining critical information. Lastly, the model outputs are optimized using Kalman filtering. This study collects radar data from real vehicles to train the radar model. Testing has demonstrated that the radar model developed by this paper’s method yields outputs very close to actual radar predictions, with a significant improvement in prediction accuracy compared to traditional radar models. The model operates in approximately 0.8 ms, markedly faster than the real radar’s 72-millisecond detection cycle. This demonstrates that the radar model developed using this modeling method can predict radar detection results accurately and in real-time.
Sovereign CDS Spread and Term Structure Forecasting Based on Neural Network
Authors: Abid Amira , Suissi Nada
Published: October 2024

The article aims to forecast credit risk for BRICS countries using daily credit default swaps (CDS) spreads obtained from Datastream data base from 2018 to 2023. Our approach consists, first, of forecasting the CDS spread in order to estimate the forecasted CDS term structure. The general regression neural network (GRNN) is used to predict the CDS spread. By checking the accuracy of the prediction, the results show that the GRNN model can be recommended as an effective forecasting tool for CDS spread. Second, the predicted spreads are used to estimate the forecasted CDS term structure using the Nelson–Siegel model. The results show that for Russia, overall, the CDS spreads in the long term are less than those in the short term, which implies that the future outlook is more optimistic, given the events that occurred during the study period, but it still retains the highest level of credit risk compared to other countries. Unlike Brazil, India and South Africa, the future outlook is more pessimistic. For China, the term structure is unstable; in the short term, there is a tendency to reduce the risk, but for longer horizons, the risk will increase. Thus, BRICS countries have different risk profiles depending on investment horizons. The study’s findings help policymakers in developing tailored risk management strategies for BRICS countries and guide investors in making informed credit investment decisions. The use of advanced forecasting tools like GRNN and Nelson–Siegel models emphasizes the importance of sophisticated techniques in enhancing financial market resilience.
Sociodemographic Influence on the Management of Orofacial Cleft in Urban and Rural Indonesia
Authors: Hasanuddin H. , Al-Jamaei Aisha AH. , Ruslin M. , Steijlen Fridus , Tajrin A. , Helder M. N. , Forouzanfar T.
Published: October 2024

Objective

To explore the social experiences of orofacial cleft patients and contextualize sociodemographic influence on management disparities in rural and urban areas of Indonesia.

Design

This study explores patients’ lives in two demographical settings in South Sulawesi Province, Makassar and Selayar Islands Regency. It employs ethnography, including open-ended interviews and observations of patients, their neighborhoods, schools, and workplaces. Secondary data from the two regencies and South Sulawesi province are employed to demonstrate demographic disparities in patient care between urban and rural areas. Thematic content analysis was performed according to socio-demographical differences and networks involved in the management.

Participants

This study engaged a diverse group of participants, including patients, family caregivers, medical team members, and patient peers (n = 40), primarily from middle to low-income families.

Results

Parents in both regions had limited knowledge about treatment modalities, which resulted in concerns regarding the safety of surgical procedures and the postponement of mandatory surgeries. In rural areas, patients faced significant financial burdens when referred to Makassar. In contrast to parents in Selayar, parents in Makassar prioritized more social interaction to ensure that their children attended school, college, and work. Patients in both settings reported facing various obstacles at different stages of their lives.

Conclusions

Sociodemographic conditions contribute to disparities in treatment, social positioning, and self-perception. Promoting education about the safety of medical and rural surgical procedures is vital. Involving patients in public activities and providing support from family caregivers is paramount to nurturing patients’ optimistic outlooks.