bluuebunny/crossref_metadata_2025 huggingface dataset:
The evaluation of the performance of the heat exchanger of a triple concentric tube configuration with ionic liquid (imidazolium) and MWCNT ionanofluid
Authors: HASAN Huda Majid , ABDULMAJEED Basma Abbas
Published: November 2023

In this study, a triple concentric tube heat exchanger (TCTHE) was designed. It had three copper concentric tubes. Their thicknesses were 0.762 mm, 1.143 mm, and 1.27 mm. The diameters were 9.525 mm, 22.25 mm, and 34.925 mm, respectively. The tube’s length was 670 mm. The cooling medium used was the ionic-liquid (IL) 1-Ethyl-3-methylimidazoliumtetra-flouraborate [EMIM][BF4] and the ionanofluid (INF) prepared of 0.5% Multi walled carbon nanotubes (MWCNT) in [EMIM][BF4], while oil forty stock was the hot fluid, to investigate TCTHE performance. The volumetric flow rate (VFR) of the cooling medium was 20-55 l/hr, with a 25-27 °C temperature (temp). VFR of the hot fluid was constant and equal 20 l/hr. The inlet oil temp was 50, 60, and 70 oC, respectively. The type of flow was countercurrent. The heat transfer was investigated by calculating different parameters for the cooling medium. There was an improvement in the Nusselt number (NU) of INF of 5% compared to the IL. A 75% increase in the friction factor of INF was found compared to that of IL. A 95% increase in the pressure drop was calculated in the inner tube using INF compared with that of IL. The overall heat transfer coefficient (U) was enhanced by 3% using INF in comparison with IL. Fi-nally, U showed some improvement, resulting in increased heat transfer. In conclusion, using the prepared INF lead to improve the heat transfer in the TCTHE.
Paediatric blunt abdominal trauma with organ injury: a comprehensive analysis of cases at a tertiary hospital in Bangladesh
Authors: Hossain M. Zamil , Ali M. Nowshad , Saha Amar Kumar , Shahid S. M. Ahsan , Paul Shantona Rani
Published: November 2023

Background: Pediatric blunt abdominal trauma with organ injuries is a critical issue in Bangladesh, lacking sufficient research. This study focuses on managing such cases in a tertiary hospital. Objectives were to assess clinical characteristics, injury patterns, and outcomes of pediatric patients with blunt abdominal trauma and organ injuries. It aims to identify causes, associated injuries, and hospital stay durations.
Methods: A prospective study of 142 pediatric patients aged 1-12 was conducted at Rajshahi medical college hospital study period January 2020 to December 2021. In addition, this study aimed to identify and grade solid organ injuries according to the American association for the surgery of trauma organ injury scale.
Results: Prevalence of hepatic injuries (76.8%), solid organ injuries (90.1%), road traffic accidents (71.8%), falls from height (25.4%). Most received conservative treatment, had short hospital stays, and a 7% mortality rate. Gender had no significant impact on organ injuries (p>0.001). Among the causes, 84.5% had hepatic injuries, 15.5% had spleen injuries due to road traffic accidents, and 58.3% had injuries from falls from height, with a highly significant cause-organ injury relationship (p<0.001).
Conclusions: pediatric blunt abdominal injuries in Bangladesh affect various organs, primarily in males and school-aged children, primarily due to road accidents. Timely surgical intervention and preventive measures are crucial for improved outcomes.
Association of neonatal hyperbilirubinemia with cord albumin among term appropriate for gestational age neonates
Authors: Shah Shweta K. , Jha Anand K. , Sharma Satish , Gupta Sanjay
Published: November 2023

Background: Neonatal hyperbilirubinemia (NH) is the most common abnormality seen during the neonatal period. It affects nearly 60% of term and 80% of preterm neonates during the first week of life. Early discharge of healthy term and late preterm newborns after normal vaginal delivery is a common practice however there are reports of bilirubin induced brain damage (kernicterus) occurring in these infants. Therefore, to ascertain whether cord albumin can be used as a reliable indicator for predicting neonatal hyperbilirubinemia.
Methods: A tertiary care hospital-based cross-sectional study was conducted in 142 healthy late preterm and term newborns of either gender with icterus appearing only after 24 hour of life with no other illness using a non-probability sampling method. Data analysis was done using statistical package for the social sciences (SPSS) version 16. Chi-square was used to determine the association between cord albumin and hyperbilirubinemia.
Results: There is a significant negative correlation between cord albumin and serum bilirubin at 72-96 hours of life (p=0.001). A total of 142 healthy late preterm and term neonates included. The study group based on Cord serum albumin (CSA) levels ≤2.8 g/dl, 2.9-3.3 g/dl, and ≥3.4 g/dl shows 77.27%, 22.7% and none respectively developed NH requiring phototherapy. According to receiver operating curve (ROC) analysis, the cutoff point of 2.75 g/dl provides the best sensitivity and specificity result.
Conclusions: Cord serum albumin level ≥3.4 g/dl are probably safe for early discharge whereas cord serum albumin level <3.4 g/dl will need a close follow-up to check for the development of jaundice.
Evaluation of haematological scoring system as a screening tool for early detection of neonatal sepsis
Authors: Radhakrishnan Akshay , K. R. Jayaram Sankar
Published: November 2023

Background: Early diagnosis of neonatal septicemia is a vexing problem because of its nonspecific clinical picture. Hence the timely diagnosis of sepsis in neonates is critical as the illness can be rapidly progressive and, in some instances, fatal. The current study was undertaken to assess the significance of the hematological scoring system (HSS) for early detection of neonatal sepsis. Objectives were to assess the effectiveness of HSS in early detection of neonatal sepsis by comparing it with blood culture result, in neonates who were clinically suspected to have bacterial infection
Methods: This is a descriptive study done in TDMCH, Vandanam for a period of 1 year. All babies who were at risk of developing sepsis were studied after applying inclusion and exclusion criteria. Blood samples were collected and subjected to sepsis work up. HSS scoring was done. Sensitivity, specificity, positive predictive value (PPV), Negative predictive value (NPV) of HSS and each of its components were calculated.
Results: Among the 85 neonates studied, 39 (45.9%) were blood culture positive, 42 (49.4%) had HSS score of 5 or more. HSS score had sensitivity of 92.31%, specificity of 86.96%, PPV of 85.71% and NPV of 93.02%.
Conclusions: HSS score of ≥5 had high NPV and would play a major role in ruling out neonatal sepsis.
Pulmonary tuberculoma: does persistent imaging lesion equals treatment failure?
Authors: Lopes Vilma , Pinho Joana , Rangel Maria Adriana , Guimarães Tânia , Carvalho Isabel
Published: November 2023

Pulmonary tuberculoma is a rare but challenging entity for paediatricians, regarding diagnosis and management. Treatment course is still up for discussion since tuberculomas may persist after treatment. The authors report two paediatric cases, both recently treated for latent tuberculosis infection, admitted for investigation of a solid pulmonary nodule. In both cases the thoracic CT scan showed a nodular subpleural lesion and the biopsy revealed epithelioid cells with areas of necrosis and calcification. The diagnosis of pulmonary tuberculosis was confirmed in one case by detection of acid-fast bacilli in the smear and in the other by nucleic acid amplification test for M. tuberculosis. The patients presented good response to treatment with antituberculosis drugs, without need for surgical resection. These reports highlight the diagnostic and treatment challenges of this rare entity.
Effects of radiotherapy for tumors of the larynx and hypopharynx in hearing levels
Authors: Aguiar Cristina , Carvalho Ana F. , Nobre Ana R. , Branquinho Francisco
Published: November 2023

The head and neck oncological patients are susceptible, either because of tumor location or the treatments performed, to changes of their ear structures. Due to close proximity of radiation field to the ear, radiotherapy induces short and long-term toxicities to the external, middle and internal ear. The aim of this study was to evaluate the impact of radiotherapy on the inner ear. We conducted a cross-sectional retrospective study of patients with cancer of the larynx and hypopharynx undergoing radiotherapy alone or adjuvant to surgery. The follow-up period was 1 year. Relevant clinical and audiological variables were analyzed. We included 15 patients, mostly males, with a median age of 66 years. Average hearing threshold (AHT) deterioration was found in 13 ears, with a median of 8.1dB. Mean bone conduction threshold at 4000 Hz, air conduction threshold at 8000 Hz at 12 months and the median of the final air conduction threshold at 10,000 Hz was significantly higher than the pre-treatment. A correlation was observed between final AHT and dosage of radiation per fraction. Thus, for each increase of 1 Gy per fraction there was an increase of 22.13 dB in the final AHT. About half of the patients had deterioration of the final AHT, proving, on the one hand, the sensorineural hearing loss associated with radiotherapy, while emphasizing the need to perform long-term follow-up protocols for early auditory rehabilitation of these patients.
Unusual presentations of branchial cyst
Authors: Hajare Priti S. , Metgudmath Vinita V. , Mehadi Izhak , K. Neema , Babu Elsa , Nayak Dhanush
Published: November 2023

Branchial cyst is a developmental cyst commonly presenting as a solitary, painless neck mass, typically located over lateral aspect of the neck. Most commonly located along the anterior border and the upper third of the sternocleidomastoid muscle in the anterior triangle of the neck, it is very rare for a branchial cyst to manifest in other locations. Branchial cysts are believed to be derived from the branchial apparatus, mostly from the second branchial arch, although many theories have been proposed to explain the aetiology of branchial cysts. Congenital branchial cysts of the nasopharynx originate from the lateral nasopharynx with an inferior and medial extension. This rare and unusual occurrence of the cyst is characterised by its avid mucus secretion and unilateral presentation. Here we present four different presentations of branchial cyst - as a midline swelling, an unusually large presentation, nasopharyngeal presentation. Histopathology report showed cyst lined by stratified squamous epithelium and pseudo stratified ciliated columnar epithelium at places along with subepithelial lymphocytes suggesting branchial cyst. Hence, Branchial cyst should also be taken as one of the differential diagnoses in cystic lesions of the neck and lateral cystic lesions of nasopharynx.
Middle ear neuroendocrine tumour-case report of a rare tumour of the temporal bone
Authors: Bhat Manali , Vijayendra H. , Vijayendra Vinay Kumar , Mahajan Nilesh
Published: November 2023

Several conditions are known to present as masses in the middle ear medial to an intact tympanic membrane. Reddish masses that blanch on seigelization are usually paragangliomas. Sometimes, a high rising jugular bulb or an aberrant carotid artery can also be seen. Whitish masses are usually congenital cholesteatomas, tympanosclerosis, cartilage grafts that have been surgically placed, and rarely middle ear adenomas (MEA).  An elderly male presented with decreased hearing, which was revealed to be secondary to a pale mass in the middle ear, displacing the intact tympanic membrane laterally. He underwent biopsy followed by complete excision of the mass, with preservation of the intact ossicular chain. There no evidence of recurrence on follow-up. Histopathology revealed the mass to be a MEA, also known as middle ear neuroendocrine tumour (MeNET). Middle ear neuroendocrine tumours are rare tumours. We describe the clinical presentation and management of this tumour.
Itraconazole versus steroids in post operative cases of allergic fungal rhinosinusitis: a randomized controlled trial
Authors: Aggarwal Ankit , Goel Khushboo , Bhagat Sanjeev , Sahni Dimple , Sharma Dinesh Kumar , Yadav Vishav
Published: November 2023

This study was aimed to compare the effect of oral steroids and itraconazole in reducing the recurrence in allergic fungal rhinosinusitis (AFRS) patients undergoing ESS. In this randomized controlled trial, 50 patients of both sexes aged between 15-60 years with AFRS were subjected to functional endoscopic sinus surgery (ESS). In the post-operative period, patients were randomly divided into 2 groups containing 25 patients each. Group A received systemic steroid followed by topical steroid. Group B received oral itraconazole. Patients were followed at the end of 6, 10 and 14 weeks after surgery. Sinonasal outcome test 22 (SNOT-22) Lund Kennedy endoscopic score (LKES), AEC and serum total IgE were repeated at each post-operative visit and compared with the preoperative values. Repeat NCCT nose and PNS was done at 14th week to look for recurrence. Statistically significant difference was seen between the two groups in AEC, LKES and SNOT-22 with group A showing more significant improvement than group B, but not in serum IgE and Lund Mackay computed tomography (LMCT) score. The group A had 24% (n=6) recurrence rate, while group B had 44% (n=11) recurrence rate. The difference in the two groups in recurrence was not statistically significant. We evaluated multiple parameters including radiological and endoscopic scores to find the difference between the two drugs and found steroid to be superior than itraconazole.
Dinámicas espacio-temporales de la deforestación en los municipios de Riosucio y Río Quito, Chocó, Colombia
Authors: Restrepo Jhon , Hoyos Natalia , Restrepo Juan
Published: November 2023

La deforestación tiene efectos globales y locales que incluyen las emisiones de gases de efecto invernadero, la erosión de los suelos, los cambios en el ciclo hidrológico y la pérdida de biodiversidad. Este estudio tuvo como objetivo analizar los patrones espaciales y temporales de la deforestación en los municipios de Riosucio y Río Quito en la región del Pacífico colombiano en el periodo de 2015 a 2020 y modelar un escenario de la tendencia de la deforestación para el periodo 2020-2025. El análisis de la deforestación histórica (2015-2020) se hizo a partir de la base de datos de Global Forest Change, en tanto que el escenario futuro (2020-2025) se modeló a partir de la plataforma Dinamica EGO que también se usó para evaluar los efectos de múltiples variables en la deforestación. Los resultados indicaron que las distancias reducidas con respecto a áreas previamente deforestadas, a zonas de explotación de oro de aluvión, a cuerpos de agua y a ríos, así como las pendientes bajas, favorecen la deforestación en ambos municipios. La proximidad a cuerpos de agua fue la variable que más influyó en la deforestación en Riosucio, mientras que la proximidad a áreas de explotación de oro de aluvión fue la más relevante en Río Quito. La simulación de la deforestación para el año 2025 arrojó un aumento de 3,1 % en Riosucio y de 7,3 % en Río Quito comparada con la del periodo 2015-2020. Nuestros resultados difieren parcialmente de lo encontrado en otros estudios nacionales y regionales, lo que se explica por la diferencia en la definición y resolución espacial de ciertas variables. Por ello se requieren estudios locales que sirvan de insumo para las estrategias de control y reducción de la deforestación.
HISTORICAL ASPECTS AND OVERVIEW OF LEGAL UNDERSTANDING OF AIRSPACE SOVEREIGNTY CONCEPT
Authors: Vodolaskova Kateryna , Holovko Svitlana
Published: November 2023

Goal: define different ideas of the concept of "sovereignty in aviation space" and consider the stages of development of the concept of airspace sovereignty in the context of the airspace bordering the territory of the state. Research methods: documentary analysis and synthesis, comparative analysis, cognitive and analytical, as well as methods of systematization and generalizations. Results: the analysis of legal acts of international significance in the field of aviation law, which determined the modern understanding of the concept of sovereignty in airspace, was carried out. Discussion: deep analysis made it possible to determine that the official recognition of airspace sovereignty under international law gave all states the right to establish rules and exercise sovereign control of any power over their sovereign airspace.
ЗМІНА ПРОФІЛЬНОГО ЗАКОНУ ПРО ВІРТУАЛЬНІ АКТИВИ: ІМПЛЕМЕНТАЦІЯ ЄВРОПЕЙСЬКОГО РЕГЛАМЕНТУ MiCA
Authors: Грицай Сергій
Published: November 2023

Мета: Верховна Рада України прийняла 17.02.2022 р. Закон України «Про віртуальні активи» № 2074-IX. Повноцінний запуск українського ринку віртуальних активів планувався законодавцями з 01.10.2022 р. одночасно з прийняттям Законопроекту № 7150, який так досі і не був прийнятий (на момент проведення дослідження). Що саме стало причиною і які наслідки це може мати, ми і спробуємо встановити, провівши дослідження у даній роботі. Методологічна основа дослідження включає в себе сукупність філософських, загальнонаукових і спеціальних правових методів наукового пізнання. При проведенні дослідження використовувалася система методів наукового пізнання. Результати: перша редакція Закону України «Про віртуальні активи», прийнята 15.03.2022 р., стала індикатором того, що у перспективі українські компанії та міжнародні інвестори зможуть легально працювати в Україні. Але на сьогоднішньому етапі Закон України «Про віртуальні активи» носить більш декларативний характер. І розкриє свій потенціал тільки після приведення його до норм регламенту MiCA, створення та затвердження підзаконних актів. Обговорення: за період із 17.02.2022 р., а саме з моменту ухвалення Парламентом України Закону № 2074 та до початку 2023 року, відбулися значні події. Серед таких впливових подій можна відзначити той факт, що 23.06.2022 р. Україна набула статусу кандидата на членство в Європейський Союз. Одночасно з цим, Європейський Союз суттєво оновив Регламент регулювання ринку криптоактивів (MіCA). Тому вітчизняне законодавство, що регулює віртуальні активи, необхідно переглянути, через імплементацію Регламенту регулювання ринку криптоактивів.
ОСОБЛИВОСТІ УКЛАДАННЯ ПРАВОЧИНІВ У МEРEЖI IНТEРНEТ
Authors: Мостова Галина
Published: November 2023

Мeтoю стaттi є аналіз законодавства України, яке регулює укладення правочинів у мережі Інтернет, вітчизняних наукових праць із цього питання, а також досвіду зарубіжних країн задля знаходження шляхів вдосконалення національного законодавства, яке регулює вказаний інститут права. Методологічною основою виступають зaгaльнонауковi тa спeцiaльнi мeтoди нaукoвoгo пiзнaння. Викoристaння цих мeтoдiв дaлo мoжливiсть виявити тa oписaти особливості укладання правочинів у мережі Інтернет. Результати: у чинному законодавстві України відсутнє однозначне визначення електронного договору щодо віднесення його до письмових правочинів чи окремого виду правочинів. Тому вбачається за доцільне віднести електронні договори до письмових видів правочинів, як це визначено в Цивільному кодексі України та привести у відповідність із цивільним законодавством інші нормативно-правові акти, які регулюють інститут електронних договорів. При цьому слід законодавчо закріпити чіткі вимоги щодо електронних договорів, опираючись на міжнародний досвід. Обговорення: у Типовому законі про електронну торгівлю 1996 року, а також у Кoнвeнцiї ООН прo викoристaння eлeктрoнних пoвiдoмлeнь у мiжнaрoдних дoгoвoрaх 2005 рoку визнaченi: умoви, зa яких eлeктрoнний дoкумeнт мoже прирiвнювaтися зa юридичнoю силoю дo письмoвoгo дoкумeнтa; умoви, зa яких eлeктрoнний дoкумeнт мoжe ввaжaтися пiдписaним; умoви, зa яких eлeктрoнний дoкумент прирiвнюється дo oригiнaлу дoкумeнтa. Aнaлогiчнi вимоги слiд зaстосувати i щодо електронних договорiв тa внести до чинного Цивiльнoгo кoдeксу Укрaїни, a вiдпoвiднo й дo iнших нoрмaтивнo-прaвoвих aктiв, щo рeгулюють iнститут електронних договорiв. Тaкож розглянутi рiзнi форми оферти тa aкцепту. Наголошено, що чіткі та однозначні вимоги щодо форми оферти та акцепту мають вирішальне значення для дійсності електронного правочину.
КРИМІНАЛЬНА ВІДПОВІДАЛЬНІСТЬ ЗА СТ. 110-2 КК УКРАЇНИ «ФІНАНСУВАННЯ ДІЙ, ВЧИНЕНИХ З МЕТОЮ НАСИЛЬНИЦЬКОЇ ЗМІНИ ЧИ ПОВАЛЕННЯ КОНСТИТУЦІЙНОГО ЛАДУ АБО ЗАХОПЛЕННЯ ДЕРЖАВНОЇ ВЛАДИ, ЗМІНИ МЕЖ ТЕРИТОРІЇ АБО ДЕРЖАВНОГО КОРДОНУ УКРАЇНИ»
Authors: Лисько Тетяна , Макознак Софія
Published: November 2023

Мета: визначення характеру й природи кримінальної відповідальності за злочин, передбачений ст. 110-2 КК України «Фінансування дій, вчинених з метою насильницької зміни чи повалення конституційного ладу або захоплення державної влади, зміни меж території або державного кордону України». Методи дослідження: загальнонаукові методи пізнання, за допомогою яких автори досліджують та розв’язують проблему встановлення кримінально-правового змісту конститутивних ознак злочину, передбаченого ст. 110-2 КК України. Результати: автори визначають суттєві ознаки, які притаманні даному злочину, вказують на проблеми їх кримінально-правового визначення. Обговорення: констатовано, що даний злочин потребує більш пильної уваги зі сторони науковців та правозастосовців в умовах воєнного стану, оскільки містить окремі термінологічні проблеми та колізійні аспекти.
АДМІНІСТРАТИВНЕ ПРАВОПОРУШЕННЯ (ПРОСТУПОК) – ЙОГО ПРИЧИНИ ТА ПРОФІЛАКТИКА
Authors: Бутенко Артем
Published: November 2023

Метою статті є дослідження понятійного апарату у визначених предметом дослідження питаннях, обговорення проблем, пов’язаних з адміністративною деліктологією, профілактики протиправних дій, які підпадають під визначення як адміністративні правопорушення (проступки). Методологічну основу роботи складає комплексний підхід щодо дослідження понятійного апарату в адміністративній деліктології, профілактики адміністративних правопорушень (проступків). Її основою є діалектичний, аналітичний та порівняльний методи дослідження, які забезпечують виявлення внутрішньої сутності явищ через характеристику їх розвитку та проявів на практиці. Результати: необхідність дослідження проблематики щодо адміністративних правопорушень (проступків) пов’язана з важливістю розуміння їх змісту, причин скоєння та профілактики, а також із вдосконаленням чинного законодавства у даній галузі відповідно до сучасних напрямків розвитку законодавства в Україні. Обговорення: крім доктринального призначення та застосування у навчальному процесі матеріалів даної статті, важливо звернути увгу на її актуальність щодо законотворчого і законодавчого процесу.
ПИТАННЯ НЕЙТРАЛІЗАЦІЇ ВРАЗЛИВОСТЕЙ ІНФОРМАЦІЙНО-КОМУНІКАЦІЙНИХ СИСТЕМ ЦИВІЛЬНОЇ АВІАЦІЇ: ПРАВОВИЙ АСПЕКТ
Authors: Криволап Євгеній , Юринець Юлія , Бєлкін Леонід
Published: November 2023

Метою статті є дослідження сучасних підходів до правового регулювання у сфері виявлення, нейтралізації та управління вразливостями інформаційно-комунікаційних систем, у тому числі – цивільної авіації. Методи дослідження: документальний аналіз, узагальнення правової інформації, інформації із сфери кіберзахисту інформаційно-комунікаційних систем, а також практики кіберзахисту інформації від різноманітних кібератак. Результати: встановлено, що у найбільш концентрованому вигляді під вразливістю системи слід розуміти нездатність системи протистояти реалізації певної загрози або сукупності загроз, що особливо небезпечно на авіаційному транспорті. У зв’язку із цим питання протидії кіберзагрозам стає предметом спеціальної уваги в авіаційній сфері, у тому Міжнародної організації цивільної авіації (ІКАО), а також інших міжнародних організацій у сфері авіаційного транспорту (Міжнародна асоціація повітряного транспорту (ІАТА), Міжнародна координаційна рада асоціацій космічної промисловості (ІККАІА) тощо). В Україні законом затверджена Державна Програма авіаційної безпеки цивільної авіації. Разом із тим, підсилення кібербезпеки на авіаційному транспорті здійснюється в контексті запровадження загальних методів та принципів кібербезпеки. Важливим кроком запровадження в Україні системи нейтралізації вразливостей слід вважати законодавче врегулювання процедур Bug bounty – тестування електронних сервісів із залученням зовнішніх фахівців, яке дає можливість виявити вразливі місця і недоліки в програмних продуктах. Регулювання здійснюється Порядком пошуку та виявлення потенційної вразливості інформаційних (автоматизованих), електронних комунікаційних, інформаційно-комунікаційних систем, електронних комунікаційних мереж, затвердженим постановою Кабінету Міністрів України від 16.05.2023 р. № 497. Обговорення: удосконалення правового регулювання у сфері виявлення, нейтралізації та управління вразливостями інформаційно-комунікаційних систем, у тому числі цивільної авіації, сприятиме підвищенню безпеки цивільної авіації.
ICAO: HISTORICAL BACKGROUND, INSTITUTIONAL FRAMEWORK AND COMPETENCE
Authors: Vodolaskova Kateryna , Holovko Svitlana
Published: November 2023

The purpose of the study is a historical and law analysis of the historical background of the formation and development of the ICAO as well as a legal framework of its institutional framework and competence stipulated in the Chicago Convention. Research methods: the methodological background of this study includes methods of historicism, analytics, formal-dogmatic and systemic. Results: this year, the National Aviation University is celebrating its 90th anniversary since its official foundation, when the Kyiv Aviation Institute was founded on the basis of the Aviation Faculty of KMI by Decree of the Council of People’s Commissars of the USSR No. 1815 of 08/25/1933. However, in fact, the prerequisites for this official recognition and establishment were certain conditions based on enthusiasm, technical progress, the development of international civil aviation, and the need for a clear distinction between military and civil aviation. These and other conditions also became a condition for the creation of the ICAO – a specialized UN agency that organizes and coordinates international cooperation of states in all aspects of civil aviation. Discussion: this work is dedicated to research of the historical background, institutional framework, and competence of ICAO. These studies will also take contribution to the understanding of the conditions and background of formation and development of NAU in a more comprehensive way.
Decrease of prothrombin level during thrombolysis in acute myocardium infarction
Authors: Korolova Daria  S. , Parkhomenko Alexander  M. , Chernyshenko Volodymyr , Chernyshenko Tamara  M. , Druzhyna Nadiya  M. , Hornytska Olha  V. , Platonova Tetyana  M.
Published: November 2023

Previously, the direct interactions of Bβ26-42 fibrin residues with prothrombin were demonstrated. It was also shown that forming prothrombin complexes with E- or DDE-fragments causes non-enzymatic prothrombin activation. The direct measuring of the prothrombin level in the blood plasma of patients with acute myocardial infarction (AMI) allowed us to find a situation where such an activation can occur in vivo. Blood coagulation parameters in the blood plasma of patients with AMI were measured at 2 hours, three days, and seven days after the thrombolysis by streptokinase accompanied with intravenous administration of anticoagulants: unfractionated high molecular weight heparin (HMWH) and low-molecular-weight heparin (LMWH). The prothrombin level in the blood plasma of patients with AMI was normal before thrombolytic therapy and substantially decreased after streptokinase administration. This effect was prominent in the case of concomitant anticoagulant therapy with LMWH and was not observed when HMWH was applied. It can be explained by the fact that LMWH preferentially inhibits factor Xa, while the HMWH is an effective inhibitor of both factor Xa and thrombin. This observation suggested that the prothrombin level decrease was caused by the thrombin-like activity and possible autolysis of prothrombin by thrombin. Also, thrombolytic therapy with streptokinase caused the accumulation of fibrin degradation products (FDPs), some of which were able to bind prothrombin. The dramatic decrease of prothrombin level in the blood plasma of patients with AMI during thrombolysis allowed us to conclude the non-enzymatic prothrombin activation with the following autolysis of prothrombin that contributes to the pathology.
The Effect of Ultraviolet Radiation on Mechanical Properties of Fused Deposition Modeling 3D Printed Materials
Authors: Pandžić Adi , Kadrić Edin , Kadrić Džana , Hodžić Damir
Published: November 2023

This study investigates the influence of ultraviolet (UV) radiation on the mechanical properties of Fused Deposition Modeling (FDM) 3D printed materials, specifically polycarbonate (PC) and polylactic acid (PLA) specimens. The research involves conducting experiments on five test specimens of each material exposed to UV radiation and comparing their mechanical properties to those of five control specimens that remain unexposed. The results reveal a significant mean difference between the mechanical properties of the control and UV-exposed materials. UV radiation caused a decrease in tensile strength for the PC material, while the PLA material exhibited an increase in tensile strength. The impact of UV radiation on PLA was more substantial compared to PC. Flexural strength testing showed an enhancement in strength for the UV-treated materials, with UV treatment having a greater influence on the flexural strength of PLA compared to PC. The mechanical properties of PLA were more significantly impacted by UV radiation than those of PC. The study findings suggest that PC and PLA materials exhibit different responses to UV exposure, which may have implications for their practical applications. Further research is needed to fully understand the underlying mechanisms governing these divergent responses and to optimize the performance of each material under UV radiation.
Interdisciplinary Contributions in the Design of Assistive Products With 3D Printing Technology
Authors: González-Maldonado Caridad , Maldonado-Garcés Verónica , Calenda Andreina
Published: November 2023

This work shows an interdisciplinary approach between product design, psychology, and electronic engineering disciplines. The contributions, knowledge, and results for the creation of assistance products from this research process are focused on the principle of inclusion of people with disabilities. The review of the scientific literature on the topic addressed is related to human-centered design from a comprehensive vision that recognizes needs while respecting the principle of individuality. The hypothesis suggests that products designed for individuals with disabilities gain significance when developed through an interdisciplinary approach within the context of collective knowledge-building. This process was carried out using additive 3D printing technology. We worked through a case study and functional prototyping of an upper torso exoskeleton and arm exoprosthesis for people with the total absence of both upper limbs. This project's main objective is to offer accessible resources that improve the quality of life of people with physical disabilities. The main results are an iterative synergy between the actors, a functional and personalized product, and a valorization of assistive technologies and materials for a practical design.
Hybrid Ethno-Project Based Learning Integrated With Virtual Assistive Technology to Enhance Students' Critical Thinking in Fundamental Physics Course
Authors: Wahyudi Wahyudi , Putu Verawati Ni Nyoman Sri , Islahudin Islahudin , Agustina Syafira
Published: November 2023

The study explores the implementation of a novel pedagogical approach, hybrid ethnoscience-project based learning (E-PjBL) integrated with virtual assistive technology (VAT), to cultivate CT skills among students in a basic physics course. The E-PjBL framework integrates relevant cultural contexts and real-world projects into the physics curriculum. The presence of VAT provides a visual learning experience regarding ethnoscience contexts while also serving as a means to explain physics concepts at a high level of abstraction. The findings of our experiments reveal that students exposed to this hybrid approach show significant improvement in their CT skills, such as analysis, inference, evaluation, and decision-making. This research contributes to the growing knowledge of effective pedagogies that support the development of CT skills in the context of physics.
Sentiment Analysis Model Development on E-Money Service Complaints
Authors: Tahyudin Imam , Rafi Hananto Andhika , Anggun Rahayu Silvia , Anjani Rayinda Maya , Nurhopipah Ade
Published: November 2023

Technology provides various conveniences for users in many aspects, such as in the commercial business world with the development of financial technology or fintech. In Indonesia, there are fintech services with the most users, namely OVO and DANA. Various kinds of criticisms and suggestions related to deficiencies and weaknesses in OVO and DANA services were submitted by users via social media Twitter. This study aims to analyze and develop a sentiment identification model for user complaints against OVO and DANA services on Twitter. This study uses the four classification algorithm methods: Random Forest, K-NN, Decision Tree, and Naïve Bayes Classifier. The data from social media Twitter is taken from user tweets regarding criticism and complaints on OVO and DANA services. The data obtained was 5,000 instances consisting of 20% positive and 80% negative reviews. Accuracy values represent the study results with 87% for Naive Bayes, 86% for Decision Tree, 91% for K-NN, and 87% for Random Forest. Based on these results, it can be concluded that testing of sentiment analysis on user complaints on OVO and DANA services using the K-NN algorithm is superior to the other algorithms. This research results in a system that combines the four prediction models. The evaluation shows that the developed model can accurately classify user sentiment.
Role of Insertion/Deletion Polymorphism for Angiotensin Converting Enzyme Gene in Hypertension
Authors: Alić Anesa , Avdić Aldijana , Hercegovac Amela , Alić Adin , Pođanin Maja , Šehić Melisa , Mešanović Semir , Dautbašić Aldijana , Brzović Senad , Kurtćehajić Admir
Published: November 2023

Insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene is a key component of the Renin-Angiotensin-Aldosterone System (RAAS). It has been proposed as an independent factor for hypertension and other cardiovascular diseases. Consequently, it has been extensively studied in various populations. The aim of this study is to investigate I/D polymorphism of ACE gene and its connection to hypertension in population of Tuzla Canton (Bosnia & Herzegovina). The study included 60 hypertensive subjects and 60 healthy control subjects with no risk factors for hypertension. I/D polymorphism was genotyped by polymerase chain reaction followed by gel electrophoresis and data obtained were statistically analysed using Chi square test. Odd’s ratios were calculated with a 95% confidence interval. P-value < 0.05 was considered significant. Odd’s ratios were calculated with a 95% confidence interval. P-value <0.05 was considered significant. Higher frequency of genotype D/D and allele D was determined in subjects with hypertension compared to control subjects but there is no statistical significance (p>0.05). However, statistically significant association was found in compared groups of subjects with genotypes DD + ID, in regards to genotype I/I (p<0.05). The results indicate the conclusion that ACE I/D polymorphism cannot be considered the main risk factor for development of hypertension, but its influence should be investigated together with other genetic and acquired risk factors that are associated with hypertension. This research contributes to the on-going exploration of molecular-genetic associations with hypertension.
Strategy for the development of adaptive student sports of NRU “MEI”
Authors:   National Research University “Moscow Power Engineering Institute”, Brilenok Naila B. , Cherepanova Irina O. ,   National Research University “Moscow Power Engineering Institute”
Published: November 2023

The article highlights the innovative way of development of adaptive student sports at the NRU “MEI” in general, and motor rehabilitation of students of a special medical group, in particular. The proposed strategy is a unique realisable project being implemented, integrally combining a technological scientifically grounded approach to the problem under study, and the practical effective implementation of a multi-component motor rehabilitation model operating in its basic basis with an instrumental component of student sports.
The effects of “soft fitness” classes on the psychophysical state of the first-year students
Authors:   National Research University “Moscow Power Engineering Institute”, Maskaeva Tatiana Yu.
Published: November 2023

The purpose of this study was to examine the effects of “soft fitness” on the psychophysical state of the firstyear female students. It was assumed that the integrated use of the elements of yoga, Pilates, autogenic training in physical education classes at a university would help reduce the stress levels among the female students, increase emotional stability, develop the control skills in regulating their own psycho-emotional states and, as a result, improve mental and physical well-being. The study was conducted on the basis of the Russian University of Transport with the first-year students aged 17–19 years old, from whom 2 groups were formed, i.e. experimental (EG) (n = 23) and control (CG) (n = 21). In the EG, the classes were conducted using soft fitness means. In the CG, according to the traditional program, general physical training means were used. Research methods included: psychodiagnostic tests such as “Situational and Personal Anxiety Scale” by Spielberger – Khanin, “Assessment of mental activation, interest, emotional tone, tension and comfort” by L. A. Kurgansky – T. A. Nemchina; physical fitness tests (strength endurance, flexibility, vestibular stability); functional tests such as Shtang, Genchi, Serkin, Ruffier index. During the experiment, a significant advantage of the author’s method was established compared to the traditional approach, which was reflected in a significant improvement in indicators of flexibility, static and strength endurance of the core muscles, vestibular stability (balance function), in results of the functional tests (Stange, Genchi, Serkin, Ruffier index) and some indicators of the mental state of the female students from the EG compared to the CG.
Features of teaching sambo wrestling in universities
Authors:   National Research University “Moscow Power Engineering Institute”, Kuznetsov Pavel A.
Published: November 2023

The article deals with the issues of teaching sambo wrestling at the non-sporting educational organizations of higher education in view of the specifics of teaching physical culture in these institutions, which consist in a lower number of hours for teaching this sports discipline compared to sports schools, as well as in the fact that it is not a major subject for a non-sporting university.
Annexin-A5 Overexpression Increases Sensitivity of MCF-7 and MCF-7/ADR Cells to Epirubicin
Authors: Ghasemi Mahshad , Reiazi Niloofar , Behzad-Behbahani Abbas , Takhshid Mohammad Ali
Published: November 2023

Background: Multi-drug resistance is an important challenge in the chemotherapy of cancer. The role of annexin A5 (ANXA5) in the biology of cancer has been the focus of many studies. Breast Cancer (BC) is frequent cancer in women with high morbidity and mortality rate. The present study aimed to investigate the effects of ANXA5 overexpression on the anti-tumor activity of Epirubicin (EPI) in MCF-7 and MCF-7/ADR cells.
Methods: MCF-7 and MCF-7/ADR cells were transfected with the pAdenoVator-CMV-ANXA5-IRES-GFP plasmid or mock plasmid. The overexpression of ANXA5 was evaluated using qPCR. The effects of ANXA5 overexpression and EPI on the cell viability of MCF-7 and MCF-7/ADR cells were measured using an MTT assay. Cell apoptosis was measured by annexin V/7-AAD flow cytometry assay.
Results: Following the overexpression of ANXA5, the viability of MCF-7 and MCF-7/ADR was significantly decreased. Furthermore, the overexpression of ANXA5 in MCF-7 cells increased the cytotoxic effects of EPI in all doses and reduced the IC50 of EPI from 17.69 µM to 4.07 µM. Similarly, the overexpression of ANXA5 in MCF7-ADR cells reduced the IC50 of EPI from 27.3 µM to 6.69 µM. ANXA5 overexpression alone or combined with EPI treatment increased the apoptosis of MCF7 and MCF7-ADR cells. 
Conclusion: The results of the present study demonstrate that ANXA5 overexpression increases the sensitivity of MCF-7 and MCF-7/ADR to EPI, suggesting a possible beneficial role of ANXA5 in the therapy of BC.
Building the taxonomic profile of the Riniaie Marwah hot spring of Kishtwar in Jammu and Kashmir: the first high-throughput sequencing-based metagenome study
Authors: Wani Atif Khurshid , Ahmad Suhail , Américo-Pinheiro Juliana Heloisa Pinê , Tizro Nazli , Singh Reena
Published: November 2023

Background and Objectives: Rinaie Marwah hot spring Kishtwar (RMHSK) is one of the geothermal springs located at 33°51′51′′N 75°32′07′′E with an elevation of 2134 meters above sea level in Jammu and Kashmir, India. We aimed to study the microbial diversity of this geothermal spring using metagenomics.
Materials and Methods: In the present study, physiochemical parameters including temperature (65-75oC), pH (6. 9-8. 8), hardness (250 ppm), and mineral content was measured along with the microbial diversity using Illumina MiSeq metage- nome-based 16s amplicon sequencing (V3-V4). The sequence reads were classified taxonomically into 31 phyla, 71 classes, 152 orders, 256 families, 410 genus, and 665 species. QIIME 2 (Quantitative Insights into Microbial Ecology), an extensible, powerful, and decentralized analytical tool, was used for taxonomic analysis.
Results: Bacteroidota (32. 57%) was the dominant phylum, Bacteroidia (32. 51%) the dominant class, Bacteroidales (16. 6%) the dominant order, and Lentimicrobiaceae (14. 23%) was the dominant family per the abundance analysis. Shannon (2. 28) and Chao 1 (87. 0) diversity indices support the existence of higher microbial diversity in RMHSK (50717 OTUs).
Conclusion: The microbial diversity of RMHSK is reported for the first time through a metagenomic study. Identification of microorganisms with characteristics that are relevant to industries.
Evaluation of the physicochemical properties and bacterial loads of selected rivers in Ondo State, Nigeria
Authors: Bello Olorunjuwon O , Akinpeloye Bridget O , Bello Temitope K , Oluwafemi Yinka D , Osungbemiro Bamikole W.
Published: November 2023

Background and Objectives: Water is crucial to human existence but may be contaminated with microorganisms, thus making it unfit for consumption. This study aimed to evaluate the physicochemical properties and bacterial loads of selected river waters in Ondo State, Nigeria.
Materials and Methods: Ten major rivers were sampled between April and August, 2021. The pH, temperature, total al- kalinity, colour, turbidity, electrical conductivity, dissolved oxygen, ammonium, aluminium, organic matters, nitrate levels including the microbial loads were determined according to standard procedures. Confirmation of identified isolates was achieved by API 20E and API 20NE.
Results: The turbidity, colour, conductivity, ammonium, and aluminium ranged from 4.3 to 15.2 NTU, 4 to 20 NTU, 123.5 to 580.2 mgL-1, 0 to 3.5 mgL-1, and 0.05 to 1.7, respectively. Most physicochemical parameters showed no significant differences from the WHO permissible limits for drinking water (p > 0.05). The total viable bacterial count in the rivers ranged from 1.5 × 105 to 6.3 × 105 CFUmL-1, while the total coliform count ranged from 1.3 × 103 to 4.8 × 103 CFUmL-1. The predominant bacteria were Escherichia coli and Pseudomonas aeruginosa.
Conclusion: This study revealed that the physiochemical properties of the waters were majorly within the WHO permissible standards but with significantly higher bacterial loads.
Cost-Effectiveness Analysis of Antihypertensive Therapy in Outpatient Hypertension Patients at Hospital X in Wajo Regency
Authors: Rahmah Safitri Alya , Ibrahim Ismail , Adhayanti Ida
Published: November 2023

Background: Hypertension is a chronic disease that cannot be cured and can only be controlled but requires long-term treatment, even for life. The variety of antihypertensive treatments makes it necessary to adjust the choice of treatment not only in terms of effectiveness, but also in terms of cost. Therefore, a pharmacoeconomic approach is needed, namely Cost Effectiveness Analysis (CEA) to compare the effectiveness of therapy and costs of several alternative therapies used.
Materials and Methods: This research is observational using a descriptive research design through a pharmacoeconomic analysis approach, namely Cost-Effectiveness Analysis. The data collection technique was retrospective by accessing data from medical records of outpatient hypertension patients who met the inclusion criteria. Data taken for cost-effectiveness analysis are data on antihypertensive effectiveness and direct medical costs.
Results: The combination of two antihypertensive drugs Calcium Channel Blocker (CCB) and Angiotensin II Receptor Blocker (ARB) with an ACER value of IDR 2,996 is the most cost-effective compared to the other combination groups.
Conclusion: The combination of two antihypertensive drugs Calcium Channel Blocker (CCB) and Angiotensin II Receptor Blocker (ARB) with an ACER value of IDR 2,996 is the most cost-effective compared to the other combination groups.
Prehod mladostnikov in mladih odraslih iz pediatričnega v zdravstveno varstvo odraslih na primarni ravni: pregled stanja po svetu in v Sloveniji
Authors: Štucin Gantar Irena , Orehek Kirbiš Marta , Ivankovič Kacjan Mojca , Vogrin Bernarda , Pekarović Džakulin Vesna
Published: November 2023

Število otrok s kronično boleznijo ali razvojno motnjo tako v Sloveniji kot po svetu raste. Ocenjuje se, da delež dosega že od 15 do 30 %. V Sloveniji večina otrok in mladostnikov s kronično boleznijo živi doma, le manjši delež je institucionaliziranih. Ko adolescenti in mladi odrasli (AMO) dosežejo določeno starost, preidejo iz zdravstvenega varstva otrok v zdravstveno varstvo odraslih. Voden prehod je še posebej pomemben za AMO s posebnimi potrebami. Način in hitrost prehoda od pediatra do družinskega zdravnika je še v večini zdravstvenih sistemov siva cona. Tudi v Sloveniji še nimamo oblikovanih smernic za načrtovanje in izvedbo prehoda na nivoju primarnega zdravstva. V prispevku smo pripravili pregled smernic, ki že delujejo v zdravstvenih sistemih po svetu. Na podlagi izkušenj iz tujine in z upoštevanjem organizacije zdravstvenega varstva pri nas smo si začeli prizadevati za oblikovanje slovenskih smernic prehoda za AMO.