bluuebunny/crossref_metadata_2025 huggingface dataset:
Working Capital Management and Stock Performance: Evidence from an Emerging Market
Authors: Blenman Lloyd , Pham Hung T , Dao Tu V , Le Ben
Published: October 2022

Previous research found a negative relationship between net working capital (NWC) and firm risk without accounting for investor protection. Bangladesh is different. We find a positive relationship between NWC and firm risk in an environment with weak governance and lax protection of property rights. Higher NWC must maintain to balance firm risk. Financial reporting quality (FRQ), liquidity risk, revenue uncertainty and weak capital market access have impact on firm risk. Poor FRQ adversely affects cost of capital and also limited financing choice. Changes in NWC have a significant impact on stock performance in firms with slower sales growth and less access to external capital. Our finding’s reliability is supported by both the fixed-effects panel and GMM regressions. The results have implications for Bangladeshi investors and firm managers as well as for other emerging markets with limited capital market access, high cost of bank debt and weak enforcement of property rights.
关于公路工程施工质量控制与管理问题分析
Authors: 崔 菲 , 张 靖
Published: October 2022

无论怎样的建筑工程均应确保工程建设质量，工程建筑质量与工程整体使用效果、使用寿命、使用安全等方面有着直接的关系，因此在进行工程施工过程中应强化施工质量管理工作。公路工程施工具有一定的复杂性，其施工工期较长，影响质量的因素也相对较多，在施工过程中其中一个施工环节出现问题就会给公路工程整体建设质量带来不利的影响，还会导致安全问题的发生。因此为了确保公路工程建设质量，应强化施工质量管理并掌握施工管理工作要点，从而提升施工质量管理工作效率与水平，提升公路工程整体建设质量，更好的推动公路工程领域发展。
机电安装工程的管理与成本控制分析
Authors: 孔 荷香
Published: October 2022

机电工程作为现代工程项目中必不可少的组成内容，直接影响着工程项目的建设效果。为了进一步提高机电安装水平，同时保证安装项目的经济效益，应当加强成本管理控制。文中在明确机电安装工程管理内容的基础上，细致地分析了机电安装管理要点，探讨了成本控制措施，并且对机电工程未来发展进行了探讨，以期为机电工程相关工作人员提供参考。
论房屋建筑工程施工技术及现场施工管理方法
Authors: 刘 俊
Published: October 2022

随着经济的全面发展，加快了房屋建筑施工技术的革新进程，能够助力房屋建筑工程项目施工作业顺利实施。结合房屋建筑工程的施工现状，突出了施工技术管理作业的重要性，并且需要将现场施工管理作业包含在内，根据阶段性的施工质量进行全面检验，监督施工作业有序进行。在房屋建筑工程建设阶段，其施工技术水平，对后续的质量和安全具有直接影响，应引起管理、监督等部门的高度重视，将优化施工技术应用成效作为基本前提，积极落实现场施工管理工作，提高房屋建筑工程施工技术应用水平。以全方位的管理形式，改善现场施工作业质量，提高房屋建筑工程的安全系数。
浅谈道路桥梁工程存在的质量问题及管理措施
Authors: 杨 伐
Published: October 2022

目前我国道路桥梁工程技术在不断提高，混凝土道路桥梁工程施工仍然存在一些问题，例如开裂、断板等道路桥梁工程质量问题，严重威胁我国交通道路桥梁工程的使用寿命。直接导致我国道路桥梁安全出现严重问题，我国广大人民群众必须引起全面高度重视。因此文中就从水泥混凝土道路桥梁工程的设计、养护、施工、使用等多个方面分析道路桥梁工程存在的质量问题，通过具体的分析找到道路桥梁工程问题产生的原因，给出相应的解决思路、措施和方案。
论在建筑工程项目管理中的施工现场管理与优化措施
Authors: 蔡 振松
Published: October 2022

在工程建筑项目施工现场中，实际的施工仍存在着很多的管理问题；综合现阶段的建筑工程项目管理效果来看，现场管理成效还需要进一步提升，这样才能更好的保证建筑工程项目管理得到实质性的发挥。建筑工程在进行现场施工管理的时候，因为人员流动和各种施工材料的摆放会影响管理工作的质量，因此需要对现场施工管理实行更加全面管理。而在现场管理的工作重点对象就有施工人员、施工材料等；但是又因为建筑工程项目施工中各个施工进度管理要求不同，因此就需要全面性的现场管理优化，才能够保障施工的质量和施工的安全。基于此，文章就以建筑工程项目管理中的施工现场管理进行探析，对所出现的问题进行提出，并结合实际情况提出相应的优化措施，希望借此能够提升建筑工程项目管理的能力。
基于BIM的安全管理问题的研究
Authors: 张 晶
Published: October 2022

社会每个领域都在经历深刻变革，采用有效的安全管理模式是企业进步的关键。文中对BIM技术展开系统性研究，同时充分分析了当下公司中存在的安全管理问题，进而对BIM技术的综合应用进行讨论，希望能够为相关企业和工作人员带来帮助。
建筑项目的造价咨询管理及全过程成本控制策略
Authors: 宫 敏
Published: October 2022

在进行建筑工程管理工作时工程造价咨询工作是主要的管理内容之一，造价咨询管理模式可以使造价工作更加专业、更加准确，在提升工程造价计算结果准确性的基础上实现对成本的有效控制。从第三方管理单位来看，在进行工程造价咨询管理工作时应落实相关管理标准及管理准则，确保提供的服务可以满足施工企业实际要求。通常情况下，在进行施工成本控制过程中施工企业应先了解工程实际情况并对工程造价过程中的风险进行有效控制。同时还应强化施工成本管控，确保投资管理效率，提升建筑企业经济效益，更好的推动建筑企业发展。
危险化学品企业的安全管理探讨
Authors: 王 雅峰 , 李 睿哲
Published: October 2022

化学工业随着社会主义的不断发展迎来了新的发展机遇，但是同时也面临着新的挑战。近些年时长发生危险化学企业安全事故新闻，造成的损失十分惨重，不但对工业的发展产生阻碍，还会对社会稳定、经济发展产生一定的负面影响。为了提高危险化学品企业安全管理水平，文章从危险识别、风险分类、安全管理措施等方面进行探讨，以期为相关工作者提供参考。
水利工程施工安全与质量管理中常见问题及解决措施
Authors: 郭 金锋 , 郭 嘉琪
Published: October 2022

作为一项基础类工程项目，水利工程施工建设十分关键，不但能够达到生产与生活的需要，而且提高了对水资源的利用率，有助于降低灾害的发生几率。由于水利工程所处的地理环境十分复杂，对施工人员的要求不断提升。因为水利工程的施工质量、安全与最终的经济收益密切相关，所以，加大对水利工程施工安全和质量的管控力度可谓十分关键，有助于完成既定的工程施工管控任务。通过分析水利工程施工质量和安全管理过程中出现的相关问题，同时提出了有效的处理策略，并结合具体案例，制定出水利工程施工安全和质量管理的方案，从而增强水利工程施工质量与安全管控的实际成效。
论高校青年教师如何平衡教学和科研的关系
Authors: 陈 一春
Published: October 2022

高校青年教师面对教学和科研压力，如何平衡两者之间的关系，关乎着青年教师个人成长与职业发展，也影响着学校的学科建设和人才培养。对青年教师在教学和科研工作中面临的问题进行了分析和探讨，并提出了改进措施，以帮助青年教师平衡教学和科研的关系，更好地完成教学和科研任务，助力青年教师成长，促进高校师资队伍健康发展。
军校学员教与学体验问卷开发初探
Authors: 赵 文 , 郑 应生 , 何 滔
Published: October 2022

本研究在借鉴国内外课程体验问卷的基础上，对303名大学生进行问卷调查，形成了《军校学员教与学体验问卷》。通过探索性因子分析确定正式问卷共48个项目，结构包括6个因子：学习支持与资源、优质教学、学习与训练量、一般能力、激发智能、考核合理化。试测表明问卷具有良好的信度和效度。
传统武术与中医融合对传统武术发展的启示
Authors: 杨 海燕 , 庞 微微 , 王 祥
Published: October 2022

运用文献资料法、逻辑分析法等对武医融合的历史溯源进行文献综述，总结武医融合的当代价值：注重以人为本，治未病，提高身体健康水平；更好地促进传统武术与中医的发展；为全民健身贡献力量；提升文化自信；铸牢中华民族共同体意识。就武医融合视角下传统武术发展提出以下路径：渗透武术思政教育；武术传承注重哲理并重，打练结合；重武医复合型人才的培养；充分发挥传统武术在全民健身的作用。
倒立训练对海军飞行员身心素质的影响研究
Authors: 吴 海平 , 姚 泽龙 , 徐 阳阳
Published: October 2022

倒立作为传统的健身项目，受到大众广泛关注，但是在《军事体育训练大纲》训练中并没有对倒立训练提出要求，因此本研究通过理论分析倒立动作结构，发力特点，以及训练过程中产生的良好作用。建议手倒立训练可以补充到军事体育训练大纲，作为飞行学员必训必考课目。
短跑运动员核心力量训练作用与训练方法研究
Authors: 钟 桂清
Published: October 2022

本研究采用文献研究法、逻辑分析法等研究方法，对短跑运动员进行核心力量训练的作用和训练方法进行研究，研究发现短跑运动员的竞技成绩由多因素构成，其中核心力量训练是提升短跑运动员运动成绩的重要因素。因此将文章主要分成三个部分，第一部分阐述了核心区与核心力量训练的概念；第二部分结合短跑专项技术特点，深入分析短跑运动员核心力量训练的作用；第三部分从核心稳定性训练和核心专门性训练两方面分析提出短跑运动员核心力量训练可采用的方法与手段。
军校军事体育士官教员在岗培养对策研究
Authors: 王 雷 , 梁 世杰 , 杨 勇
Published: October 2022

为提高军校军事体育士官教员的岗位任职能力，保证军校军事体育教学训练质量，通过文献资料、问卷调查、逻辑分析等方法，对军校军事体育士官教员的来源与岗位任职能力进行分析，提出了相应的培养对策，为军事体育士官教员在岗培养提供了参考。
电力自动化变压器检修系统处理技术的探讨
Authors: 陈 志辉
Published: October 2022

文章主要分析电力自动化变压器检修系统处理技术的概念及使用要求，具体解读电力自动化变压器检修系统处理技术的概念，电力自动化变压器检修系统处理技术的使用要求。探讨电力自动化变压器检修系统处理技术的重要意义，论述OLAP系统的建立，需关注数据准备、数据模型、建立系统模型、分析系统数据、设备状态预警等多个环节。最后分析了关于电力自动化变压器检修系统处理技术的应用可行性，致力于掌握更多关于此系统的应用技巧，合理应用于电力系统的运行过程中，为我国电力行业的可持续发展提供无尽的动力。
特高压交流输电线路关键技术应用
Authors: 胡 洪炜 , 李 明
Published: October 2022

近些年伴随着特高压交流线路输电技术的不断完善，在现阶段也占据在显著的优势，还能够调整国内能源的分配以及电负荷的不均衡。由此可以看出，特高压交流电技术在一定程度上能够维持线路输电的安全性以及稳定性，因此，想要让优势得到保障，就需要针对特高压输电技术开展相关的研究与分析，并加强对该技术的控制，从而使特高压输电技术得到高效的利用。
智能机器人巡检系统在煤矿井下应用分析
Authors: 周 俊鹏
Published: October 2022

为保证井下带式输送机稳定、连续运行，促进矿井生产作业安全开展，文中依据煤矿井下作业实际需求设计出一套智能机器人巡检系统。并融合智能化技术，打造托辊磨损监测、电动机故障报警、机器人沿线巡检三个基础子系统，实现对带式输送机运行状态参数的全过程采集。与此同时，又对机器人本体功能进行优化，在各系统、智能化生产设备、机器人本体的协同作业下，获得理想中的巡检系统运行效果。
精细化管理在现代水利工程管理上的应用分析
Authors: 谭 子俊
Published: October 2022

随着我国社会经济的不断发展，我国对于能源利用加强了重视程度，并加强了水利工程建设力度。水利工程的有效建设不仅可以减少洪水灾害，同时还能够对水资源合理运用。在水利工程建设中，应当做好水利工程管理工作，确保水利工程建设质量达到标准要求，发挥出水利工程建设的价值以及功能，提高水利工程的运行质量以及安全。为此，项目单位务必要对水利工程管理工作提高重视程度，采取精细化管理手段，加大工程人员培训管理力度，优化管理模式以及管理体系，尽可能融入现代化信息技术，促使水利工程管理工作得到全面落实，以此确保水利工程建设质量得到全面提升，为社会稳定和谐发展提供良好帮助。
工程机械中先进液压控制技术应用研究
Authors: 秦 建宁 , 张 亚军
Published: October 2022

21世纪，人民对生活品质的要求越来越高。因此，在城市建设过程中，需要构建更加完整、安全的水力控制体系。由于工程液压系统在实际应用中的应用，不但在生产上有了长足的发展，更是体现了高效、环保的理念。目前，在中国的工业生产中，工程液压系统已经占据了绝对的主导地位。但是，随着我国工业化进程的加快，在工程机械的工作中，液压系统难免会遇到一些问题和故障。
三峡水库某公路边坡稳定性分析
Authors: 乔 素云 , 王 少华 , 尹 金涛 , 李 泉龙 , 李 顺涛
Published: October 2022

边坡稳定性分析是岩土工程中的重要研究内容，边坡稳定性分析的观点的变化是随着人类理论方面的突破和实践经验的积累不断变化的。文中以三峡库区某库岸公路边坡为研究对象，通过现场实际勘测和室内资料的分析，结合边坡变形破坏特征，确定其变形破坏模式。通过运用Geo-Studio软件建立稳定分析计算模型，运用极限平衡法，找出危险滑面，计算其安全系数，计算工况包括天然、暴雨、地震、库水位升降工况下的边坡稳定性。结果表明：该段边坡结构欠稳，易发生变形破坏。结合实际，进一步提出了一些边坡维护建议。
电力营销服务新管理体系的研究与研究
Authors: 李 景 , 崔 佳
Published: October 2022

为进一步贯彻落实国网公司“五个不动摇”、“四个统筹好”等决策部署，认真落实 “三首理念”和高质量争先发展工作方案，结合国网公司提出的“阳光业扩”服务工作要求，以“高质量发展”为核心，以“精益化管理”为抓手，以优化客户体验为努力方向，以提升服务质效为重点任务，依托公司智能电网建设成果，电力企业率先提出了“一核三辅一延伸”阳光服务管理体系的构建。从变革服务模式、创新服务技术、优化服务流程、完善服务手段等多个方面入手，在实践中探索出一条以客户需求为导向，适应市场环境的高质量发展的服务管理之路，使电力营销服务更加优质便捷、精益高效。“一核三辅一延伸”阳光服务管理体系在提升服务质量，公司形象，客户感知等方面取得了一定的成绩，是深入贯彻国家相关工作要求的创新之举。
浅谈病险水闸安全评价
Authors: 徐 剑锋
Published: October 2022

水闸是控制流量和调节水位的低水头水工建筑物，是水利设施中最重要组成部分。通过对水闸的综合调度，关闭闸门可以拦洪、挡潮或抬高上游水位，以满足灌溉、发电、航运、水产、工业和生活用水等需要；开启闸门，可以泄洪、排涝、排污，也可对下游河道或渠道供水。为工农业生产提供必不可少的基础保障。为了充分发挥水闸的综合效益与作用，保障水闸的运行安全，管理单位就必须全面掌握所管辖范围内水闸运行当中存在的安全隐患，做好水闸安全鉴定评价工作。
水利水电施工导流及围堰技术分析
Authors: 高 斌
Published: October 2022

我国各项民生基础工程的不断的建设和发展，促使我国水利水电工程也在发展和完善，相关的施工工作者对于有关专业技术的学习和实践之后，对以后的工程建设提供了很强大的基础性条件。对于目前我国水利水电工程建设施工的特点，在对围堰的工程技术进行创新以后，对传统型中技术的问题进行了改善，通过目前的创新措施对围堰工艺有效的创新，促进建设施工的导流形成，保证时间成本的降低，并且对其工程的品质进行了提升，促使人们的使用效果提升。
小型农田水利工程建设问题的探究
Authors: 瓦里托夫 艾买提汗 •
Published: October 2022

在农业发展过程中，水利工程使其至关重要的组成部分，直接影响着农业的健康发展。因此必须要对农田水利工程施工质量予以高度的重视。在农田水利施工过程中，要从施工条件、技术以及管理等多个角度来对进行创新，对施工中出现的问题进行有效的解决，提高施工质量管理的水平。同时还要与群众的生产和生活进行有效的解决，确保水利工程施工能够更好的满足农业发展的需要。因此在文章中我们主要通过对小型农田水利工程建设的意义进行了简单的分析，然后对其建设过程中存在的问题以及解决措施进行了详细的叙述，以期为小型农田水利工程的科学建设提供一定的参考。
基于财务共享的管理会计信息化建设研究
Authors: 张 倩
Published: October 2022

在财务共享模式下，企业管理会计建设成为重要的工作内容。随着办公信息化的不断普及，管理会计信息化成为企业财务部门重点发展的工作内容。企业在不断强化自身业务范围之外，还进行不断的财务转型。管理会计信息化是财务转型环节中重要的内容，进行管理会计信息化发展不仅对于企业是非常有利的，对于整个财务领域的变革发展都是意义深远的。文章基于此，论述了财务共享模式下管理会计信息化发展的主要路径，仅供参考。
管理会计在企业风险管理中的应用
Authors: 靳 中将
Published: October 2022

企业管理工作水平从很大程度上有赖于财务管理效果，通过高效地开展财务管理工作可以将企业管理风险大大降低。管理会计作为财务部门管理工作重点主要负责企业资金运作的分析，从而为管理者提供数据支持，让管理者根据企业真实运营情况采取针对性的风险控制办法。为了进一步发挥管理会计在企业风险管理中的作用，文章首先明确了管理会计对于现代企业风险管理的重要作用，说明了常用的管理会计方法，然后分析了管理会计工作中常见的一些不足，进而提出优化改进建议。通过本文分析，有助于提升企业风险控制水平。
吐哈油田温五区块采油作业成本统计分析及控制研究
Authors: 白 瑜 , 张 苗
Published: October 2022

随着石油石化行业持续重组改革的深层次推进，国际油价震荡、市场竞争日趋激烈，我国油气开采企业的生产经营环境发生了深刻变化。一方面。中石油股份公司相继引入、推进“低成本开发战略”、 “科学发展、和谐发展”“精细化管理”等新思路和新要求，各采油管理区需要加快改变经营理念，大幅降低操作成本，提高核心竞争能力。同时油田的一般规律是经过长期的勘探开发，油田已处于高采出、高综合含水率和低单井产量阶段，主力区块步入中后期开采阶段，新的储量不能及时接替，稳产上产的难度越来越大；伴随着开发时间的增长，生产设施装备陈旧老化问题突出，要求逐年投入很多措施作业费、维护修理费等成本支出来弥补自然递减，以维持现有产量。因此研究成本管理和控制对于吐哈油田缓解成本压力和可持续发展具有非常重要的意义。基于以上认识，历经一年多的方向选择、现场调研、数据采集和分析处理以及考核评价等工作，本篇文章主要采用了实证研究方法，定性与定量相结合、理论与实证分析相结合，和油气田企业的生产实践紧密结合，运用成本控制理论，通过成本预算、成本核算、成本分析和成本控制四个部分的实际验证，对有温米特色的成本精细化管理模式进行了分析和评价。
建筑施工企业财务风险控制与防范
Authors: 徐 新苗
Published: October 2022

近年来，由于施工项目的日益增加，给建筑施工企业的发展壮大提供了优越的环境条件，但却增强了施工企业之间的竞争，同时也提高了施工企业的财务风险。因此，建筑施工企业在发展壮大的过程中将会面临着更多的风险与挑战，为保证企业的健康发展，必须注意做好财务管理风险管理，以增强对施工企业的财务风险防范意识与控制能力，这对于建筑施工企业在激烈的市场竞争环境下保证自我的生存与发展具有十分重要的意义。文章分析了建筑施工企业财务风险的成因，并就其控制与防范措施进行探究，仅供大家参考。
资本运作在企业经营管理中的应用探讨
Authors: 柳 杰
Published: October 2022

随着我国经济的不断发展，越来越多的企业都开始注重资本运作以及经营管理，而资本企业也会在当今的经营管理工作中占据着很重要的地位。社会上很多的人们也会对企业的资本运作进行探讨和关注，也希望更多的企业能够在社会当中不断地发展与进步。现如今，我国的经济水平也在不断地上升，而资本运作也会在企业的发展过程中凸显自己的地位，由此可见，资本运作已经是企业发展过程中必不可少的一员了。因此，文章基于资本运作在企业经营管理中的应用进行了探讨，仅供参考。
新形势下工程招投标与合同管理途径解析
Authors: 温 大海
Published: October 2022

随着社会经济的不断发展，科技水平进一步提高虽然在这一期间，工程的招标和合同管理取得了良好成果，但招标中的违规行为、评标中的问题以及合同管理中的违规行为是阻碍和阻碍该部门长期发展的主要因素为此，建筑项目管理人员必须高度重视建筑工程的招标和合同管理，考虑到两者之间的内在关系，采取有效措施确保建筑项目的顺利进行，并提高建筑项目的总体质量。在此基础上，文中将阐述新形势下建设项目招投标和合同管理的具体方法和途径，希望从中汲取经验教训。
内控导向人力资源管理实践与组织绩效研究
Authors: 戚 丽敏
Published: October 2022

人力资源管控作为中国企业工作和管理中非常重要的内容和领域，对企业竞争力和管理水平的提升和提升有着深远的影响。堪称新时代企业竞争的本质。但是，受企业和社会性质的影响，人力资源管理还存在一些问题。新时期人力资源管理的缺陷和不足越来越明显。资源管理理念，用人力资源管理为企业经济效益的提升做出贡献。在当今市场经济建设中，信息化的应用已成为时代的主流。鉴于信息化管理的重要性，在事业单位改革过程中，也积极推进信息化建设，从而构建完善的人力资源管理信息系统，并依托信息化系统的优势，提高水平为机构改革发展培养更多优秀人才，实现机构服务功能，促进机构发展。文章对内控导向人力资源管理实践与组织绩效进行了研究分析，以供参考。
管理会计在建筑企业财务管理中的应用分析
Authors: 王 建国
Published: October 2022

随着市场经济不断发展，企业内部组织也发生着改变，要想实现企业经营最优化，需要对企业管理模式进行创新。管理会计能够为企业经营管理提供有价值的财务信息、帮助企业管理者进行财务评价及决策，有利于企业提升财务管理水平，促进企业创造更多的经济效益，文章从管理会计的基本理论出发，对其应用的具体问题及有效措施进行了探索，以供借鉴。
建筑安装工程投标报价探析
Authors: 焦 红
Published: October 2022

建筑安装工程公司在开展工作的过程中，投标是其最重要的工作之一。在竞争日益激烈的环境中，企业通常处于合理的价格范围内，可以采取相应的措施来获得最大利润。建筑工程中的价格通常受如设备和工程的数量、材料的市场价格以及企业控制风险的能力等因素的影响。同时，投标人在计算和综合分析工程量时，要注意工程量的准确性和清单报价的准确性，这也是投标人必备的技能。
The Case of Joseph’s Coat: Giving Gifts to Children in the Hebrew Bible
Authors: Henriksen Garroway Kristine
Published: October 2022

Joseph’s coat is one of the most recognizable garments in the Hebrew Bible. In The Gift, Marcel Mauss theorizes that a gift contains part of the giver’s social persona, thus requiring a counter-gift to be given. Drawing on Mauss’s work as a heuristic category, this study investigates the economy of gifts and counter-gifts in the Hebrew Bible using Joseph’s coat as a case study. Joseph’s age at the time he receives the gift and the seeming lack of a counter-gift form the two main questions that this study investigates. To answer these questions requires determining who made the coat, a question best answered through an archaeological analysis of how textiles were created in ancient Israel. The paper concludes that an ancient audience would have understood both Jacob and Rachel to be makers of the gift, and therefore the (expected) recipients of a counter-gift. The end of the Joseph Novella suggests that this expectation was met after a period of delay, during which time Joseph grew into adulthood and rose to a position where he could properly return a gift on par with the special coat.
Eosinopenia As a Marker of Sepsis in Intensive Care Unit Patients
Authors: Begum Suraiya , Ferdousi Sheuly , Das Reba
Published: October 2022

Background: Sepsis is one of the most common causes of mortality and morbidity in the intensive care unit (ICU).
Objective: This study was done to evaluate eosinopenia as a marker of sepsis in intensive care unit patients.
Materials and Methods: This cross sectional study was carried out in the Department of Clinical Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka . AEC was done by automated cell counter and rechecked manually microscopically.
Observations and Results: In this study 74 suspected case of sepsis were enrolled from intensive care unit, BSMMU, Dhaka. To evaluate the usefulness of AEC for predicting significant sepsis the area under the ROC curve was analyzed. The area under ROC curve was 0.765 in current study. At the cut off valve of AEC < 40 cell/cu mm, the sensitivity and specificity of AEC for diagnosis of sepsis was 72.5% and 61.8% respectively.
Conclusion: This present data revealed that decreased absolute eosinophil count was significantly associated with sepsis. So eosinopenia may be a reliable marker for early diagnosis of sepsis.
Sir Salimullah Med Coll J 2022; 30: 175-179
Avascular Necrosis of Femoral Head: A Retrospective Study of MRI Scan in A Orthopedic Hospital
Authors: Sarker Snigdha , Yesmin Lovely , Pervin Rasheda , Farzana Most Nahid , Huda Noushin , Yasmin Mst Sabina , Islam Iftadul
Published: October 2022

Background : Avascular necrosis (AVN), also known as osteonecrosis of femoral head is a pathology in which many etiologies play role and cause decreased vascular supply to subchondral bone of femoral head which results in osteocyte death. MRI is the most sensitive modality for detection of AVN and is helpful for screening and detecting at early stage. Purpose: The aim of the study was to determine the prevalence pattern and stages of presentation of Avascular Necrosis (AVN) of the femoral head.
Materials and Methods: This was a retrospective study carried out at the department of Radiology & Imaging, National Institute of Traumatology & Orthopedic Rehabilitation (NITOR), Dhaka where MRI of the hip joint was performed during our study period, only those patients which showed positive signs for avascular necrosis of femoral head were included and were analysed over a period of five years. The age, sex, laterally distribution, causative factors, staging according to Ficat and Arlet classification was done.
Results: It was found that most commonly males of productive age group (21 to 40 years) were affected. Though most of them had unilateral involvement however number of bilateral cases were also significant. Mostly, patient presented with stage-IV disease accounting for 104 out of 152 patients (68.42%).
Conclusion: Considering that the young males were commonly affected and presented with advanced stage disease at the time of diagnosis, it was recommended that screening MRI should be done in all patients presenting with hip complaints.
Sir Salimullah Med Coll J 2022; 30: 180-185
O OLHAR DA PESQUISADORA SOBRE SUA TRAJETÓRIA INTELECTUAL
Authors: Zembruski Soeli Staub , Machado dos Santos Adelcio
Published: October 2022

O presente texto é resultado de pesquisa e reflexão sobre a identidade linguística da pesquisadora. Formada a partir de uma trajetória peculiar, a mesma é apresentada por meio de comparação de dados com pesquisas anteriores, desenvolvidas por outros pesquisadores da região, acerca dos falares regionais do oeste de Santa Catarina. E, se propõe a descrever o contexto multilinguístico vivenciado durante o período da primeira infância e adolescência. Ao refletir sobre sua trajetória, a professora identifica influências e confluências que compõem sua identidade linguística e as observa no contexto da docência identificando a presença, ainda que ocasional, de características linguísticas do período de aquisição da fala e escrita. O estudo é a primeira etapa de um projeto de observação das características e peculiaridades das manifestações orais no espaço acadêmico. Nesse sentido, introduz a discussão que será ampliada por um segundo texto, a ser publicado em breve, e que traz uma pesquisa e observação das manifestações de comunicação oral em turma de mestrado na qual a professora atuou no contexto pandêmico com a transição das presenciais para as síncronas. O estudo não se pretende conclusivo, e sim, mais um passo no sentido de maior compreensão do processo de comunicação humana.
Palavras chave: Linguagem. Pesquisa. Introspecção.
 
ABSTRACT
This text is the result of a research and a reflection about the researcher's linguistic identity. Built up from a peculiar pathway, it is presented in comparison with data provided by other previous researchers from the same region (Santa Catarina’s Westside). The purpose of this study is to describe the multilingual context that was experienced by the professor in her early years and adolescence. Thinking about her trajectory, she identifies influences and confluences that are part of her linguistic identity and observe them in the teaching process identifying the presence, event eventual, of característics observed in childhood and teenage years. The study is the first part of a project that observes characterics of oral communication in academic spaces. This way, it initiates the discussion that will be continued in a second text, that will be published soon, bringing a research on oral communication in a mastership program class in which the professor worked during the pandemic times and the transition from presencial classes into synchronous classes. This study does not intend to be conclusive, but another step to better comprehension about human communication.
Keywords: Language. Research. Insight.
La empresa unipersonal de responsabilidad limitada en el derecho societario del Ecuador
Authors: Vasconez-Fuentes Jose
Published: October 2022

El derecho societario se centra fundamentalmente en la necesidad de replantear la extensión del privilegio de la responsabilidad limitada en el contexto de la modernización de esta rama del derecho. Por tal razón, el objetivo se centró en especificar los factores de reforma que las empresas unipersonales necesitan para que consten en la Superintendencia de Compañías del Ecuador. El método aplicado tuvo un enfoque crítico propositivo, de carácter cualitativo, se revisó información contenida en normas y cuerpos legales, según el diseño de teoría fundamentada, que permite comparar y sustentar la normativa sobre la empresa unipersonal de responsabilidad limitada en el derecho societario del Ecuador. Se concluyó que, existen varias debilidades respecto del modelo empresarial, pues, la perspectiva de los expertos concuerda en que se debería difundir los beneficios que trae consigo la constitución de empresa unipersonal de responsabilidad limitada ya que, a causa del desconocimiento las personas que laboran en sectores informales de la producción no se interesan por constituir este tipo de modelo empresarial que brinda un blindaje jurídico a los trabajadores.
Climate induced Coastline Changes: A case study in Togo (West Africa)
Authors: Attiq Zubair , Baqi Abdul , Abbas Ali
Published: October 2022

Changing climate is a global distress these days. Global warming is one of the men driven outcome of climate change which causes the glaciers to melt, shoreline regression and raises the level of sea. The regression of shoreline in Togo resulted in vandalization of human habitat and infrastructure. This research aims to monitor the coastal erosion utilizing the geospatial techniques in Togo from 1988 to 2020. The process of extraction and existence of change in shoreline is analyzed. Scientific problems regarding the precision of classification algorithms methods utilized for shoreline extraction using various satellite images are also considered. Thus, NDWI index derived from multisource satellite images were used in this research paper. The performance of Iso Cluster Unsupervised Classification, Otsu threshold segmentation and Sup- port Vector Machine (SVM) Supervised Classification techniques are monitored for the shoreline extraction. This study also takes into account the topographic morphology including non linear and linear coastal surfaces. The rate of change of shoreline was estimated through the statistical linear regression method (LRR). The results demonstrated that the SVM Supervised Classification method worked accurately for topographic morphology than other methods.
Bioaccumulation Efficacy of Heavy Metals In Body Organs of Rainbow (Oncorhynchus Mykiss) and Brown (Salmo Trutta Fairo) Trouts of Gilgit-Baltistan
Authors: Ali Shaukat , Hussain Javid , Ali Salar , Aslam Sarwat , Khan Nilma , Din Saif Ud
Published: October 2022

Heavy metals are chemical elements that are poisonous and toxic comprising of both necessary and unnecessary trace metals. All aquatic organisms require very low amount of these metals yet in case where these values exceed to certain range, threshold harmful effects are levied upon the ecosystem. The aim of this study was to estimate the bioaccumulation of heavy and trace metals (Cr, Mn, Ni, Fe, Pb, Cu, Cd, Zn) in fish using Atomic Absorption Spectrophotometer (AAS). Samples of fish were procured from Ghizer and Astore districts of Gilgit-Baltistan region of Pakistan. The concentration of Cr, Pb, Cu and Cd were almost same and depicted low tendency of bioaccumulation as per WHO guidelines. The fish from Ghizer was having high concentration of Zn and Fe in intestine. While the concentration of Fe in muscles and intestine from the Astore species was slightly high. The highest concentration of Ni (10.09 ppm) was found in liver tissues of rainbow trout, while the lowest concentration (6.74 ppm) was in the fins of fish from Astore. In case of Cr, the highest concentration (3.8 ppm) was found in liver from both sampling sites, but the lowest concentration (0.24 ppm) was in the muscles of Ghizer Rainbow trout. The highest concentration of cu (6.09 ppm) was in the muscles of fish from Astore, but the lowest concentration (2.32 ppm) was found in many organs of fish from both study sites. Although the concentration of Zn, Mn and Fe were within the limits, however, the highest concentration of Pb (0.79 ppm) was in the muscles and the highest concentration of Cd (0.38 ppm) was in the skin of Ghizer rainbow trout. Concentration of Lead exceeded the limits of FAO/WHO in every organ of fish in both study areas, while all the other metals were in the maximum limits.
Riverbank Erosion & Consequent Land Settlement Issues: A Case of River Chenab, District Hafizabad
Authors: Aslam Rana Muhammad Sohail , Mayo Shaker Mahmood , Ahmad Ijaz , Ahmad Nisar , Arif Hania
Published: October 2022

When calamity strikes, it causes damage but it also provides opportunities for newer learnings opportunities and better preparedness to combat menace. Pakistan is agrarian economy and comprises fertile plains. According to Pakistan Bureau of Statistics, agriculture contributes to 24 percent of national Gross Domestic Product. Agriculture is dependent on water needs, met through water channels fed by rivers originating mostly from glacial sources existing in northern part of the country. The country hosts five major rivers, namely Indus Jhelum, Chenab, Ravi, and Sutlej. The dendritic river patterns follow gravity flow causing frequent morphological changes and riverbank erosion is the most significant phenomenon which acts as hazard for farming communities in terms of loss of shelter, livelihood, and landholdings. An in-time identification of the issue is the real concern nowadays. Presently, different tools are available for instant interpretation of riverbank erosion like Remote Sensing (RS) and Geographical Information System (GIS), which are not only good for instant identification but also helpful for precise estimation of historical losses. Landsat images for years 2009, 2013, and 2017 have used to make an initial assessment of erosion hotspots. High-resolution satellite imagery from Google Earth is also used for meticulous analysis. The analysis shows that beyond other factors, average riverbank displacement rate due to erosion directly depends on rise in water levels. The study provides systematic bases to estimate the losses precisely. The study is useful for damages assessment of land and livelihood to device relief packages for the affected communities. The study also builds the capacity in resolving land settlement issues consequent to the riverbank erosion phenomenon.
Analysis of Pesticides Residues in Breast Milk of primiparous and multiparous women in Gilgit
Authors: Urooj Syyeda , Nafees Maisoor Ahmed , Din Saif Ud , Ali Shaukat
Published: October 2022

Milk contains all the essential nutrients like fats, proteins, and minerals. The utilization of contaminated food can induce a proportion of pesticides in the body. The main purpose of the study was to determine the pesticide residues and current status of breast milk in primiparous and multiparous mothers. In a current study, a total of 50 samples were collected from different areas of District Gilgit and Astore. The pesticides cypermethrin, deltamethrin, and chlorpyrifos were analyzed using gas chromatography. The presence of cypermethrin in 10 samples was in a range 0.00 – 0.012 mg/kg, while the detection of Deltamethrin in 07 with variation from 0.000.12mg/kg. Whereas chlorpyrifos was found in 05 samples with the ranges of 0.00-0.0062 mg/kg. Residue level was quite higher in urban areas than rural areas. The multiparous women had prominent residues level than primiparas and the concentration of Deltamethrin was higher than other pesticides. All the pesticides residues levels in the breast milk of primiparous and multiparous mothers were within the permissible limits of WHO. Yet the women of these areas are not vulnerable but prolong exposure may pose a serious threat to neonatal and maternal health and other relevant reproductive issues. To manage the risk of milk contamination in the future, the demand for public awareness campaigns and the adoption of alternative clean approaches to control pests and other disease-spreading vectors in the best interests of public health seems reasonable.
Asphalt Pavement Potholes Localization and Segmentation using Deep RetinaNet and Conditional Random Fields
Authors: Rana Ghazanfar Ali , Adnan Syed Muhammad , Nida Nudrat , Ahmad Wakeel , Bilal Farooq
Published: October 2022

The main aspect of maintaining the roads and highways' durability and long life is to detect potholes and restore them. A huge number of accidents occur on the roads and highways due to the pothole. It also causes financial loss to vehicle owners by damaging the wheel and flat tire. For the strategies of the road management system and ITS (Intelligent Transportation System) service, it is one of the major tasks to quickly and precisely detect the potholes. To solve this problem, we have proposed a deep learning methodology to automatically detect and segment the pothole region within the asphalt pavement images. The detection of the pothole is a challenging task because of the arbitrary shape and complex structure of the pothole. In our proposed methodology, to accurately detect the pothole region, we used RetinaNet that creates the bounding box around the multiple regions. For the segmentation we used Conditional Random Field that segments the detected pothole regions obtained from RetinaNet. There are three steps in our methodology, image preprocessing, Pothole region localization, and Pothole segmentation. Our proposed methodology results show that potholes in the images were correctly localized with the best accuracy of 93.04%. Conditional Random Fields (CRF) also show good results.
Experimental Study of Turbine Blade Tip Heat Transfer with High-Speed Relative Casing Motion
Authors:   University of Michigan- Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Xie Wenbo , Peng Xu ,   University of Michigan- Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Jiang Hongmei ,   University of Michigan- Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Lu Shaopeng ,   School of Aeronautics and Astronautics, Shanghai Jiao Tong Unversity, Gu Yongmin ,   University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Chen Chien-Pin ,   University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Zhang Qiang ,   University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University
Published: October 2022

The relative casing motion can significantly influence the HP turbine blade tip aerothermal performance. The existing experimental facilities either can not achieve high rotating speeds, or have difficulties to gain full optical access to the tip region. In this study, spatially resolved squealer tip heat transfer data were obtained from Infrared thermal measurement by using a novel high-speed disk rotor rig which can mimic the high-speed casing relative motion close to actual operating turbines. The Mach number and Reynolds number were also engine realistic. Distributions of tip heat transfer coefficient at a relative casing speed of 140m/s were compared with results at stationary condition. Distinctly different thermal performance with the effect of casing motion were observed both experimentally and numerically. With closely coupled RANS CFD analysis, the flow physics behind are further discussed. The key finding in the present study highlights the importance of relative casing motion for tip aerothermal management.
NUMERICAL MODEL OF THE AXIAL TURBINE BLADE COOLING PROCESS
Authors:   Samara National Research University, Popov G. М. , Volkov A. A. ,   Samara National Research University, Baturin O. V. ,   Samara National Research University, Matveev V. N. ,   Samara National Research University, Kudryashov I. А. ,   Samara National Research University, Suleimanov A. R. ,   Samara National Research University
Published: October 2022

The article describes influence of finite-element mesh flow parameters in the blade passage of cooled turbine stator blades on results of film cooling efficiency factor calculation. Recommendations for value selection of these parameters to build simplified numerical models of flow in stator blade rows in Numeca Fine Turbo software package with simulation of coolant blowing out from cells on blade surfaces are offered.
Design Optimization of the Convergent Passage Profile of a High-Load Turbine Vane Endwall
Authors:   Xi’an Thermal Power Research Institute Co., Ltd., Liu Zhansheng , Xiao Junfeng ,   Xi’an Thermal Power Research Institute Co., Ltd., Gao Song ,   Xi’an Thermal Power Research Institute Co., Ltd., Li Yuanyuan ,   Xi’an Thermal Power Research Institute Co., Ltd., Yu Feilong ,   Xi’an Thermal Power Research Institute Co., Ltd., Duan Jingyao ,   Xi’an Thermal Power Research Institute Co., Ltd., Feng* Zhenping ,   Xi’an Jiaotong University.
Published: October 2022

Due to the application of low-NOx combustion technology, the protection of blade endwall from the hot gas has been essential for the advanced gas turbines. The reasonable design of endwall profile can not only improve the thermal efficiency of the cascade, but also reduce the heat load on the endwall. In this paper, a high-load vane endwall is taken as the research object, and the convergent passage profile of the endwall is optimized. The optimization design variables are locations of control points of the endwall shape. And the optimization objective functions are the total pressure loss coefficient of the cascade passage and the heat load on the endwall. The multi-objective genetic algorithm coupled with surrogate model is adopted. After the optimization, heat load of the endwall and total pressure loss of the cascade are reduced relative to the original design.
Predicting the data structure prior to extreme events from passive observables using echo state network
Authors: Banerjee Abhirup , Mishra Arindam , Dana Syamal K. , Hens Chittaranjan , Kapitaniak Tomasz , Kurths Jürgen , Marwan Norbert
Published: October 2022

Extreme events are defined as events that largely deviate from the nominal state of the system as observed in a time series. Due to the rarity and uncertainty of their occurrence, predicting extreme events has been challenging. In real life, some variables (passive variables) often encode significant information about the occurrence of extreme events manifested in another variable (active variable). For example, observables such as temperature, pressure, etc., act as passive variables in case of extreme precipitation events. These passive variables do not show any large excursion from the nominal condition yet carry the fingerprint of the extreme events. In this study, we propose a reservoir computation-based framework that can predict the preceding structure or pattern in the time evolution of the active variable that leads to an extreme event using information from the passive variable. An appropriate threshold height of events is a prerequisite for detecting extreme events and improving the skill of their prediction. We demonstrate that the magnitude of extreme events and the appearance of a coherent pattern before the arrival of the extreme event in a time series affect the prediction skill. Quantitatively, we confirm this using a metric describing the mean phase difference between the input time signals, which decreases when the magnitude of the extreme event is relatively higher, thereby increasing the predictability skill.
Structural behavior of cemented bahareque for social housing: A case study in Guayaquil City, Ecuador
Authors: Mite-Anastacio Fernando , Tello-Ayala Ken , García-Troncoso Natividad , Silva Christian E. , Malaga-Chuquitaype Christian , Arévalo Kleiner , Villao David
Published: October 2022

The need for social housing creates challenges for engineering. One of the most economical and ecological structural systems for certain areas is the cemented bahareque, which uses Guadua cane, a type of Bamboo with favorable properties for construction. Despite being an ancient technique for the construction of houses, there is not an extensive bibliography that allows making justified decisions regarding their design in most cases. One of the objectives of this article is to present a prototypical design of a housing case with appropriate characteristics to allow a decent occupant’s life with this construction system. For the selected house, the structural behavior is evaluated under gravitational and seismic loads. The constructive criteria that will provide good performance under seismic events are recommended. The most important criteria to follow for the design of wall systems are regularity, continuity, symmetry, bolted connections, rigid diaphragms for mezzanines and continuous maintenance of the Guadua cane elements that make up the framework of the walls. Finally, it is concluded that following the basic criteria of earthquake-resistant design for this type of housing, adequate structural performance can be obtained.
Participation of OCRL1, and APPL1, in the expression, proteolysis, phosphorylation and endosomal trafficking of megalin: Implications for Lowe Syndrome
Authors: Sandoval Lisette , Fuentealba Luz M. , Marzolo María-Paz
Published: October 2022

Megalin/LRP2 is the primary multiligand receptor for the re-absorption of low molecular weight proteins in the proximal renal tubule. Its function is significantly dependent on its endosomal trafficking. Megalin recycling from endosomal compartments is altered in an X-linked disease called Lowe Syndrome (LS), caused by mutations in the gene encoding for the phosphatidylinositol 5-phosphatase OCRL1. LS patients show increased low-molecular-weight proteins with reduced levels of megalin ectodomain in the urine and accumulation of the receptor in endosomal compartments of the proximal tubule cells. To gain insight into the deregulation of megalin in the LS condition, we silenced OCRL1 in different cell lines to evaluate megalin expression finding that it is post-transcriptionally regulated. As an indication of megalin proteolysis, we detect the ectodomain of the receptor in the culture media. Remarkably, in OCRL1 silenced cells, megalin ectodomain secretion appeared significantly reduced, according to the observation in the urine of LS patients. Besides, the silencing of APPL1, a Rab5 effector associated with OCRL1 in endocytic vesicles, also reduced the presence of megalin’s ectodomain in the culture media. In both silencing conditions, megalin cell surface levels were significantly decreased. Considering that GSK3ß-mediated megalin phosphorylation reduces receptor recycling, we determined that the endosomal distribution of megalin depends on its phosphorylation status and OCRL1 function. As a physiologic regulator of GSK3ß, we focused on insulin signaling that reduces kinase activity. Accordingly, megalin phosphorylation was significantly reduced by insulin in wild-type cells. Moreover, even though in cells with low activity of OCRL1 the insulin response was reduced, the phosphorylation of megalin was significantly decreased and the receptor at the cell surface increased, suggesting a protective role of insulin in a LS cellular model.
3D genome organization links non-coding disease-associated variants to genes
Authors: Orozco Gisela , Schoenfelder Stefan , Walker Nicolas , Eyre Stephan , Fraser Peter
Published: October 2022

Genome sequencing has revealed over 300 million genetic variations in human populations. Over 90% of variants are single nucleotide polymorphisms (SNPs), the remainder include short deletions or insertions, and small numbers of structural variants. Hundreds of thousands of these variants have been associated with specific phenotypic traits and diseases through genome wide association studies which link significant differences in variant frequencies with specific phenotypes among large groups of individuals. Only 5% of disease-associated SNPs are located in gene coding sequences, with the potential to disrupt gene expression or alter of the function of encoded proteins. The remaining 95% of disease-associated SNPs are located in non-coding DNA sequences which make up 98% of the genome. The role of non-coding, disease-associated SNPs, many of which are located at considerable distances from any gene, was at first a mystery until the discovery that gene promoters regularly interact with distal regulatory elements to control gene expression. Disease-associated SNPs are enriched at the millions of gene regulatory elements that are dispersed throughout the non-coding sequences of the genome, suggesting they function as gene regulation variants. Assigning specific regulatory elements to the genes they control is not straightforward since they can be millions of base pairs apart. In this review we describe how understanding 3D genome organization can identify specific interactions between gene promoters and distal regulatory elements and how 3D genomics can link disease-associated SNPs to their target genes. Understanding which gene or genes contribute to a specific disease is the first step in designing rational therapeutic interventions.
Improving three-dimensional human pluripotent cell culture efficiency via surface molecule coating
Authors: Li Qiang , Pan Ying , Han Li , Yang Yakun , Wu Xinran , Lei Yuguo
Published: October 2022

Human pluripotent stem cells (hPSCs) are ideal “raw materials” for making various human cell types for regenerative medicine and are needed in large numbers. 3D suspension culturing (e.g., stirred-tank bioreactor or STR), which suspends and cultures cells in an agitated medium, has been extensively studied to scale up hPSC production. However, a significant problem with 3D suspension is the uncontrolled spheroid agglomeration. It leads to cell growth arrest, cell apoptosis, and inhomogeneity in cell purity and quality. We propose that i) inhibiting the spheroid adhesion can prevent spheroid agglomeration and ii) the inhibition can be achieved via coating spheroids with biocompatible anti-adhesion molecules. We used PEG-lipids as model anti-adhesion molecules to successfully demonstrate the concept. PEG-lipids anchor to the spheroid surface through the interactions between their lipid chains and the cell membrane lipids. The flexible and hydrophilic PEG chains act as a dynamic barrier to prevent spheroid adhesion. We showed that the coating eliminated spheroid agglomeration, leading to homogenous spheroid size distribution and significant improvements in cell growth rate and volumetric yield. This novel approach is expected to impact large-scale hPSC production significantly. Furthermore, the approach can be generalized for culturing other human cell types.
Facile synthesis of lithium argyrodite Li5.5PS4.5Br1.5 with high ionic conductivity for all-solid-state batteries
Authors: Wang Shuo , Wu Xinbin , Liang Yuhan , Xu Yushuai , Guan Shundong , Wen Kaihua , Miao Xiang , Liang Ying , He Hongcai , Lin Yuanhua , Shen Yang , Nan Ce-Wen
Published: October 2022

Bromine-rich lithium argyrodite electrolytes with high ionic conductivity and low cost are promising for the replacement of flammable liquid electrolytes and separators in lithium-ion batteries. However, the synthesis process of argyrodite electrolytes is usually complex and time-consuming. We use a facile solid-state reaction method to obtain a highly Li-ion conductive Li5.5PS4.5Br1.5 (LPSB). The influence of annealing temperature on the phase and ionic conductivity of the LPSB was investigated for the first time. High ionic conductivity of 5.21 × 10−3 S cm−1 at room temperature for the LPSB with minor LiBr impurity was achieved by direct annealing at 430°C for 8 h. The In/InLi | LPSB | LiCoO2@ LiNb0.5Ta0.5O3 (LCO(coated))-LPSB cell with 8.53 mg cm−2 LCO loading shows a discharge capacity of 102 mAh g−1 with high-capacity retention of 93% after 70 cycles at 0.5 mA cm−2 at 30°C.
Features of cytomegalovirus infection and evaluation of cytomegalovirus-specific T cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: A retrospective single-center study
Authors: Ruan Yongsheng , Luo Tingting , Liu Qiujun , Liu Xuan , Chen Libai , Wen Jianyun , Xiao Yuhua , Xie Danfeng , He Yuelin , Wu Xuedong , Feng Xiaoqin
Published: October 2022

Cytomegalovirus (CMV) infection remains a critical cause of mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT), despite improvement by pre-emptive antivirus treatment. CMV-specific cytotoxic T lymphocytes (CMV-CTL) are universally used and proven well-tolerance after allo-HSCT in adult clinical trials. However, it is not comprehensively evaluated in children’s patients. Herein, we conducted a retrospective study to determine the risk factors of CMV infection and evaluation of CMV-CTL in children patients who underwent allo-HSCT. As result, a significantly poor 5-year overall survival was found in the CMV infection group (87.3 vs. 94.6%, p=0.01). Haploidentical HSCT (haplo-HSCT) was identified as an independent risk factor for CMV infection through both univariate and multivariate analyses (p<0.001, p=0.027, respectively). Furthermore, the cumulative incidence of CMV infection was statistically higher in the haplo-HSCT group compared to the HLA-matched donor group (44.2% vs. 21.6%, p<0.001). Finally, the overall response rate of CMV-CTL was 89.7% (26/29 patients) in CMV infection after allo-HSCT. We concluded that CMV infection following allo-HSCT correlated with increased mortality in children’s patients, and haplo-HSCT was an independent risk factor for CMV infection. Adoptive CMV-CTL cell therapy was safe and effective in pediatric patients with CMV infection.
Diagnostic accuracy of metagenomic next-generation sequencing for cryptococcosis in immunocompetent and immunocompromised patients
Authors: Su Yi , Miao Qing , Li Na , Hu Bi-jie , Pan Jue
Published: October 2022

Objective

To compare the diagnostic accuracy of metagenomic next-generation sequencing (mNGS) for cryptococcosis in patients with different immune statuses with that of conventional detection.

Methods

A total of 1442 specimens including 71 specimens from patients with cryptococcosis were analyzed in the study. The chi square test was used to screen the sensitivity and specificity of different detection methods for different specimen types. One-way ANOVA was used to compare the mNGS results with age, CD4, lymphocytes, IFN, IL-6, IL-2 and serum antigen assay.

Results

The sensitivity of mNGS was 44.29% in Cryptococcus infection cases. The positive rate of mNGS results for bronchoalveolar lavage fluid (BALF, 87.50%) from immunocompromised patients was higher than that of BALF from immunocompetent patients (40.00%, p=0.04). The sensitivity of the serum Cryptococcus capsular antigen assay was 80.00% in immunocompetent patients and 96.42% in immunocompromised patients (p = 0.049). A positive rate of detection of Cryptococcus from mNGS was higher when cryptococcal antigen ≥1:160 (p=0.022) in immunocompromised patients. A positive rate of detection of Cryptococcus from mNGS was higher when lymphocyte counts were lower in both immunocompetent patients(p=0.017) and in immunocompromised patients(p=0.029).

Conclusions

The sensitivity of mNGS is lower than that of serum cryptococcal antigen assay and histopathology in immunocompetent patients. However, BALF detection is recommend for immunocompromised patients compared with tissue and CSF. The positive mNGS result was correlated with lower lymphocyte counts, higher IL-2 and higher serum antigen assay in immunocompromised patients.
Reduction or de-escalation of dual antiplatelet therapy intensity or duration in patients with acute coronary syndromes undergoing percutaneous coronary intervention: A mini-review
Authors: Farag Mohamed , Jeyalan Visvesh , Ferreiro Jose Luis , Jeong Young-Hoon , Geisler Tobias , Gorog Diana A.
Published: October 2022

Current guidelines for patients with acute coronary syndrome (ACS) recommend dual antiplatelet therapy (DAPT) for 12 months. Since bleeding is the main Achilles' heel of DAPT, in recent years several randomized controlled trials have evaluated the safety and efficacy of de-escalation of DAPT with respect to ischaemic and bleeding endpoints. These trials can be broadly divided into studies evaluating a shorter duration of DAPT, and those studies in which DAPT that includes a potent P2Y12 inhibitor, such as prasugrel or ticagrelor, is compared to less intense DAPT, mainly clopidogrel or reduced-dose prasugrel. We sought to evaluate the studies assessing de-escalation of DAPT in patients with ACS undergoing PCI. We review the studies evaluating the strategies of de-escalation of DAPT intensity and those evaluating a strategy of de-escalation of DAPT duration in ACS patients undergoing PCI. We summarize the limitations of studies to date, gaps in evidence and make recommendations for future studies.