bluuebunny/crossref_metadata_2025 huggingface dataset:
IN SILICO, ANTIMICROBIAL AND CYTOTOXIC STUDIES OF CARBOXAMIDE DERIVATIVES AND THEIR GREEN SYNTHESIS
Authors:   Department of Pharmaceutics, School of Pharmaceutical Sciences, Sandip University (SUN), Mahiravani, Nashik - 422 213, Maharashtra, India, Thumula Swathi , Srinivasadesikan Venkatesan , K. Kottalanka Ravi , Samineni Ramu
Published: November 2023

5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino) phenyl) oxazolidin-5-yl) methyl) thiophene-2-carboxamide derivatives were synthesized in a simple and efficient approach using 2-(oxiran-2-ylmethyl) isoindoline-1, 3-dione, 4-(4-aminophenyl) morpholin-3-one, and 5-chlorothiophene-2-carbonyl chloride by stepwise synthesis. Three compounds 3, 4 and 7 were designed, prepared, and screened for anticancer activity against HeLa, MCF- 7, A-549 and K-562 and antibacterial activities against Gram +ve and Gram -ve strains. The carboxamide moieties proved to be capable for the development of new anticancer and anti-bacterial agents. Docking studies carried out on target receptors caspase-3 HeLa cell line and Staphylococcus aureus DNA-Gyrase also supported the anticancer and antimicrobial activity of compounds 3, 4 and 7
Growth Performance of Kuroiler (Rhode Island x White Leghorn) Chickens Fed Aflatoxin Contaminated Maize- Based Diets Treated with Different Amounts of Lemon (Limon citrus) Juice
Authors:   The University of Zambia, Kanyinji Francisco , Musukwa Ketty ,   The University of Zambia, Simbaya Joseph ,   The University of Zambia, Chibinga Oswin C. ,   The University of Zambia, Harrison Sylvia J ,   The University of Zambia, Mufungwe Joyce ,   The University of Zambia
Published: November 2023

Aflatoxin contamination in feed and feed ingredients is prevalent worldwide, and poses serious risks to both livestock and humans. This study was conducted to assess the effects of feeding Aflatoxin (AF) contaminated maize-based diets treated with varying levels of Lemon juice, to Kuroiler chickens on their growth performance. Lemon juice was extracted from fruits purchased from the local market and mixed with isocaloric and Isonitrogenic diets (starter, grower and finisher) containing AF-contaminated maize, at 0, 250, 500 and 750ml Lemon juice/Kg of feed. The diets were left to dry for 24hrs, after which 100g samples were collected from each diet to measure and compare the residual AF levels. Then, 100 day-old Kuroiler chicks were sourced from a local hatchery, and divided into four treatment groups (n = 25). Each group was replicated four times. The treatment groups were randomly assigned to 0, 250, 500, and 750ml Lemon juice/Kg feed –treated diets. These feeds and clean drinking water, were supplied to the birds ad libitum for 49 days. Feed intake was monitored every day, and body weights, weight gains, and feed conversion ratios were assessed every week. It was observed that the amount of residual AF in each diet depended on the amount of lemon juice used to treat it. Untreated diet had the highest AF levels at 36 ppb, followed by that which was treated with 250, 500, 750 ml Lemon juice/Kg feed at 28.1, 21.3, and 7.4 ppb, respectively. Growth performance variables assessed were also influenced by the amounts of residual AF levels in the diet. Birds fed diets with the lowest residual AF levels at 7.4 ppb had the best (p < 0.05) growth performance in all the variables, while the least (p < 0.05) was observed in birds fed untreated diet, followed by those that were fed diets treated with 250 and 500ml Lemon juice/Kg feed. It was concluded that Lemon juice was able to degrade AF in diets that had maize contaminated with AF, but the extent to which it inactivated it, depended on the amount of juiced used. Similarly, growth performance of birds fed diets with AF-contaminated maize treated with lemon juice was also dependent on the levels of residual AF in feeds after treatment, with the best performance observed in chickens fed diets treated with 750ml Lemon juice per Kg feed.
Efeitos da Croton Urucurana em Candida Albicans: será citotóxica?
Authors: Cunha Thalita Lisboa , Negreiros Camila Beraldo , Manzi Paola Souza , Santos Scarleth Reis de Oliveira , Salazar Geovanna Camargo , Negreiros João Victor Beraldo , De Moura Rodrigo Scaliante
Published: November 2023

A Sangra d´água, denominada cientificamente como Croton urucurana é uma árvore da espécie da família das euforbiáceas, sendo encontradas no Uruguai, Paraguai, Argentina e Brasil. Estudos relatam que a planta adquiriu inúmeras aplicabilidades na medicina popular, diante de seus prováveis resultados analgésicos, cicatrizador, anti-inflamatório, antidiarreico, em úlceras e gastrites. Além disso, há evidências de que certas espécies do gênero Croton dispõem de uma relevante atividade antifúngica e antimicrobiana aliada a uma apreciável modulação da ação de fármacos já disponíveis. Produtos naturais oriundos de vegetais, animais ou minerais têm sido largamente utilizados para tratamento de inúmeras doenças, já que têm ampla aceitação e confiabilidade popular para sua prescrição e seu uso. Esses derivados têm contribuído para o desenvolvimento de novos fármacos com o advento da engenharia genética e da tecnologia, servindo como matéria-prima e base de pesquisa. Além disso, a utilização dos insetos, especialmente dos gêneros Tenebrio ou Galleria, como alternativa aos modelos experimentais na avaliação de novos fitoterápicos se mostra muito proveitosa. Em decorrência desse fator, estes animais estão sendo selecionados como modelo para estudos relacionados a infecções microbianas. Diante desse contexto, o presente trabalho teve como objetivo identificar o tipo de ação gerada por C. urucurana em C. Albicans, com a utilização de insetos do gênero Tenebrio para tal finalidade. Para isso, foi realizado um estudo de caráter experimental, de abordagem intuitiva, no qual se obteve o extrato hidroalcóolico de C. urucurana, com rendimento no valor de 1,7%. Constatou-se que o extrato inibe o crescimento de células leveduriformes de C. albicans de modo dose-dependente, apresentando efeitos danosos à atividade mitocondrial fúngica e à parede celular, não apresentando efeitos deletérios sobre a membrana celular. Além disso, nas mesmas concentrações testadas, apresenta-se citotóxica às células humanas. Ademais, foi demonstrado um importante efeito citotóxico do extrato sobre as larvas de Tenebrio. Destarte, conclui-se que C. urucurana apresenta atividade antifúngica ao exercer efeitos sobre a parede celular e mitocôndrias fúngicas, no entanto, na mesma concentração, apresenta-se citotóxica às células humanas.
Transformação digital e suas implicações para as lideranças: estudos de casos múltiplos no varejo
Authors: Freitas Junior José Carlos da Silva , Cabral Patrícia Martins Fagundes , Maldaner Luís Felipe
Published: November 2023

A transformação digital (TD) de uma organização vai muito além do pensamento funcional, pois a palavra transformação, por si só, já considera a abrangência das ações nos diversos níveis da organização, em particular nas pessoas. Assim sendo, a presente pesquisa tem o objetivo de compreender implicações da transformação digital para as lideranças de empresas de varejo. Para isso, foram realizados um estudo de caso múltiplo em duas grandes redes de varejo do Brasil, líderes em seus respectivos segmentos, que passaram pelo processo de transformação digital. Os entrevistados foram executivos, com cargos gerenciais, responsáveis pela tomada de decisão na organização e que exercem cargos de liderança. Os resultados foram analisados em três categorias, processo decisório, competências do líder na era digital e pensamento estratégico. No que tange as competências do líder na era digital, foi evidenciado a importância do desenvolvimento de novos atributos como, capacidade de improvisação na resolução de problemas não previstos, agilidade para tomada de decisão, adaptabilidade ao novo, dentre outros. Este artigo contribui no avanço da discussão teórica e apresenta insights para gestores nos pontos de atenção para o desenvolvimento de líderes capazes de conduzir uma TD.
Still a Nation of White Immigrants? Notes on the Present Debate
Authors: Chin Gabriel J.
Published: November 2023

Recent years have generated an unprecedented popular decision about US racial identity. Before this, popular sentiment and legal policy clearly and congruently promoted immigration of white noncitizens, while severely restricting others. Until the Immigration and Nationality Act Amendments of 1965, the US law reflected Justice Grier's statement in Smith v. Turner, 48 U.S. 283, 461 (1849): “It is the cherished policy of the general government to encourage and invite Christian foreigners of our own race to seek an asylum within our borders, and to . . . add to the wealth, population, and power of the nation.” However, the 1965 reform and its successors diversified the immigrant stream and the nation, and current polls indicate that the majority of the US population now supports a generous and non-discriminatory immigration policy.
A Brief Examination of the Northernmost Appalachian Counties: Southern Tier New York
Authors: Jakubowski Casey
Published: November 2023

This note briefly overviews the history of the Appalachian region of New York State, composed of the “Southern Tier” counties from Chautauqua County in the west to Schoharie County in the east. Counties in the area are rural and historically farming-based. New York's policies are urban normative and often ignore the Southern Tier region for the benefit of larger cities. The note examines how the region has significant resources but has faced structural issues due to policy implementation by New York City and Albany-based bureaucrats. This note introduces readers outside of the area to the state's rural areas.
PENERAPAN METODE TSAQIFA DALAM KERAMPILAN MEMBACA AL-QURAN DI DESA SEPAT, MASARAN, SRAGEN, JAWA TENGAH
Authors: Suparman Fatah , Nashir M Jafar
Published: November 2023

Learning to read the Qur'an is actually not difficult, boring, or time-consuming. There are only three important stages that need to be mastered, which are mastering the Arabic letters (Hijaiyyah) and their variations, mastering the diacritical marks (harakat), and actively practicing them. Moreover, the Qur'an itself possesses miraculous and supra-rational energy. In the process of learning, we do not need to worry about difficulties, because Allah has guaranteed ease in learning the Qur'an, as stated in the Qur'an: "And We have certainly made the Qur'an easy for remembrance, so is there any who will remember?" (Surah al-Qamar: 17). The truth of Allah's promise can be proven by ourselves, as the Qur'an is indeed easy to learn for anyone who is willing to take it as a lesson. Research will be conducted on the implementation of the Tsaqifa Method, an alternative method for learning to read the Qur'an for adults who are not yet able to read, with only 5 meetings. This method was developed by Ustadz Umar Taqwim, S.Ag. and published by the Adz Dzikr Islamic Foundation, Center for Qur'anic Reading and Writing Learning (PPBTA) Tsaqifa Method in Magelang. This method is suitable for those who are busy and have limited time to learn the Qur'an. The aim of this research is to improve the skills of reading the Qur'an in Dukuh Wonorejo, Sepat Masaran Village, Sragen through the implementation of the Tsaqifa Method. Therefore, the title of this research is "The Implementation of the Tsaqifa Method in Improving Qur'anic Reading Skills in Sepat Masaran Village, Sragen." From the results of the assessment of the score range of Qur'anic reading training using the Tsaqifa method, it can be seen that the score range of 90-100 (fluent) was achieved by 4 participants, the score range of 80-90 (standard) was achieved by 4 participants, and the score range of 70-80 (satisfactory) was achieved by 18 participants. From this analysis, it can be concluded that the Tsaqifa method has an effect that is spread across a wide age range, from children to the elderly. Although there is variation in the participants' ability to read the Qur'an, comments from the trainer indicate that the majority of participants have shown progress and need further practice at home to improve their Qur'anic reading skills. Overall, the Tsaqifa method can be considered effective in helping participants understand and read the Qur'an, regardless of age and initial skill level of the participants. The improvements achieved by participants who have undergone this training can be seen from the comments of the trainer, which show that most participants have shown progress in their ability to read the Qur'an.
Toleransi Antar Umat Beragama Perspektif Al-Quran
Authors: Yanti Desy Hendri , Adde Exsan , Solihin Muhammad , Armadila A
Published: November 2023

The ability to hold oneself as an expression of this attitude of tolerance brings understanding and tolerance for differences of opinion. Dissent is normal and cannot be prohibited or suppressed. Only if all parties understand that this argument must be managed wisely in accordance with the noble values ​​of their religious beliefs, culture and traditions. The development and renewal of pluralistic theology in society is an important part of the world order which is shaped by ethnic, cultural and religious pluralism. Basically we are all brothers. Islam prohibits tolerance through the Qur'an and its hadiths. Indonesia is already known as a country that has a variety of diversity. The Qur'an's call for tolerance requires complexity and a willingness to accept all kinds of differences, including ethnicity, skin color, language, customs, culture, and religion. The Qur'an also states that the creation of the heavens and the earth, day and night, male and female is the decree of the Creator as a decree. Tolerance in Islam must always be maintained in accordance with Islamic law. Non-compliance with Sharia values ​​while maintaining tolerance has led to a shift in values ​​from tolerance that is justified within the boundaries of Islam to syncretization of religions with the principle of "all religions". All religions are the same.” This principle denies the absoluteness of religious teachings that truth only exists in Islam.
Exploration of working conditions in affecting population health and resulting in health disparities
Authors: Tang YiRui
Published: November 2023

With the development of the times, the high intensity of work and pressure in the workplace has led to more and more people in the workplace experiencing major and minor health problems. Although work is important, but not at the expense of health. Only with a healthy body and good mental state, people can do better outstanding work. This paper focuses on the impact of different working conditions on the health of the population, focusing on the impact of overwork, lack of daily exercise, high-pressure working environment, irregular work patterns and other working conditions on the population. It finds that all of the above will lead to the emergence of various types of physiological or psychological illnesses, which affect the daily life of the population as well as the expected life expectancy, and at the same time, these undesirable factors will lead to burnout and even affect the social development of the population. At the same time, these adverse factors also lead to burnout and even affect the social development of the population. In response to these problems, this paper has looked for programs and interventions that may be able to address this situation. It is hoped that more people will pay attention to the health problems caused by poor working conditions.
Research and prospect of inclusion complexes of dexibuprofen -cyclodextrin
Authors: Li Zhenglin
Published: November 2023

Dexibuprofen is an over-the-counter drug often used to relieve pain and reduce fever. However, dexibuprofen is less soluble in the gastrointestinal tract, resulting in a slower rate of absorption. In order to enhance the bioavailability, researchers have devised inclusion complexes including dexibuprofen and cyclodextrin. -cyclodextrin is a cyclic molecule characterized by its annular configuration and possesses a distinctive void structure that enables the entrapment of other molecules via an enveloping mechanism, ultimately leading to the formation of a robust inclusion complex. The incorporation of dexibuprofen into an inclusion complex resulted in enhanced stability, higher aqueous solubility, and improved oral bioavailability. Furthermore, the incorporation of the inclusion complex can potentially mitigate the gastric mucosa irritation caused by dexibuprofen and minimize the gastrointestinal tract's unfavorable effects via the inclusion combination. The inclusion complex of dexibuprofen and -cyclodextrin is a form of drug with improved solubility and bioavailability that has broad application prospects to provide more effective pain relief and fever treatment. This study focuses on the investigation of the preparation and identification of dexibuprofen clathrate through a comprehensive analysis of existing literature. The primary objective is to determine the most effective inclusion technique for dexibuprofen based on considerations of yield and clathrate rate. Additionally, the research article examined the methodology for the formulation of clathrate into dispersible tablets, along with an initial investigation into the pharmacokinetics of these tablets in rat models.
Effect of PM2.5 air pollution on the incidence of respiratory diseases: A Python-based data analysis
Authors: Yan Weiping
Published: November 2023

Air pollution is a global problem and a serious threat to public health. According to the World Health Organization, 99 percent of the world's population lives in places where air quality guideline standards are exceeded, resulting in 4.2 million premature deaths each year. Air pollution not only leads to respiratory diseases such as respiratory infections, asthma, and chronic obstructive pulmonary disease (COPD), but is also associated with chronic non-communicable diseases such as lung cancer, cardiovascular disease, and diabetes. This study analysed the relationship between the air quality index (AQI) and the incidence of respiratory diseases and found a positive correlation, i.e., the worse the air quality, the more respiratory diseases. This result is consistent with other studies and with the mechanism of the adverse effects of air pollution on the respiratory system. Therefore, this study is important for raising public awareness of the hazards of air pollution and promoting air quality improvement and respiratory health protection. This study also provides valuable information for environmental policy makers to help them consider the impacts of air quality on public health more comprehensively. This study used randomly generated data, so the results may not fully reflect what happens in the real world. Future studies need to use real environmental and health data to validate and extend our findings and provide a more sophisticated model for scenario simulation and analysis.
Comprehensive research progress in stem cell therapy
Authors: Ning Yuan
Published: November 2023

Stem cell therapy is increasingly recognized as an innovative and transformative approach in the field of medicine, with the potential to address tissue damage and manage intricate medical conditions. The utilization of induced pluripotent stem cells (iPSCs) presents a potential avenue for cardiac regeneration in the context of cardiovascular ailments, such as myocardial infarctions. Liver regeneration techniques utilizing mesenchymal stem cells (MSCs) are being offered as potential solutions for end-stage liver failure. Furthermore, stem cell therapy is regarded as a promising intervention for neurodegenerative disorders and ocular conditions, with disease-specific induced pluripotent stem cells (iPSCs) emerging as a frontrunner in prospective therapeutic approaches. The objective of this study is to investigate the advancements made in stem cell therapy research for the diseases mentioned above. It will involve a comprehensive analysis of the mechanisms and principles underlying stem cell treatment in these areas, as well as an examination of the factors that impede the progress of stem cell therapy. Additionally, this paper will offer insights into potential future directions for development in this field.
Analysis of rehabilitation therapies for sports injuries
Authors: Wang Xinying
Published: November 2023

Sports injuries are a problem that often occurs in the sports environment, and its rehabilitation research is mostly theoretical or empirical research on a certain therapy, and lacks systematic research. In this study, the literature method and logical analysis method are used to search relevant literature in various databases, and summarize the rehabilitation therapies for sports injuries, the principles, contents and treatment sequence of rehabilitation plans, in order to conduct a systematic analysis of rehabilitation research on sports injuries. It finds that the rehabilitation for sports injuries took physical and mental rehabilitation, including physical rehabilitation and psychological rehabilitation. Rehabilitation programs should be based on principles of avoidance of injury deterioration, timing of treatment, adherence, individualization, specificity assessment, intensity of recovery plans, and overall health; cover muscle strength and endurance, range of motion and flexibility of joints, proprioceptive and neurological function, cardiorespiratory endurance rehabilitation content; follow the sequence of diagnosis, identify treatment goals, primary care, intermediate care, functional rehabilitation, and circulation assessment and maintenance therapy.
Research on the influence of different factors on the incidence of cleft lip in children Taking Xinjiang as an Example
Authors: Zhong Haotong
Published: November 2023

Cleft lip and palate have always been the focus of children's medical research. This paper focuses on various environmental factors, such as the frequency of pregnant women taking prescription medicine, family medical history, and the financial status of the families. To conduct the study, this study will collect a sample of several hundred children with cleft lips and palates, utilizing existing research papers as a data source. The paper focuses on the effect of environmental factors on the incidence rate of children with cleft lips and palates in Xinjiang through literature reading. As the results show, there is statistical significance between environmental factors and the incidence rate of children with cleft lips and palates in Xinjiang. Specifically, consanguineous marriage, medicine consumption during pregnancy, disadvantageous climatic and geographic factors, and a lack of educational background all contribute to increasing the prevalence of children with CL/P among the Uyghur people.
Cognitive deficits in depressive disorder
Authors: Geng Ruhui
Published: November 2023

Depression is a globally prevalent mental disorder, often accompanied by various cognitive impairments. Cognitive impairment in depression is related to brain dysfunction, resulting from focal brain damage affecting cognitive functions. Its primary manifestations include memory loss, visual disturbances, hallucinations, executive function deficits, and difficulties in sustaining attention. Cognitive functions encompass perception, cognition, and interaction with the external environment, constituting complex brain processes. Presently, our understanding of cognitive impairment in depression remains somewhat limited, underscoring the importance of further in-depth research. Damage to specific brain regions such as the amygdala, hippocampus, and medial temporal lobe can result in cognitive deficits in severe depression patients. Interventions tailored to these lesions, such as computerized cognitive tasks and brain stimulation techniques, contribute to cognitive improvement in depression patients. Cognitive-behavioral therapy and relaxation techniques, including breath control, assist patients in reducing stress and negative emotions. Cognitive bias modification and creative art therapy promote both mental and physical well-being. Moreover, exposure to pleasant music and engaging in aerobic exercise facilitate the recovery of depression patients with cognitive impairments. Regarding pharmacological treatments, duloxetine, vortioxetine, liraglutide, intranasal insulin, and intracerebral insulin can be employed for intervention in cognitive impairment associated with depression.
Exploration of high-density lipoprotein cholesterol level and serum testosterone concentrations in adult males from NHANES, 2011----2016
Authors: Liu Donglin
Published: November 2023

Past explores have shown the expected linkage between high-thickness lipoprotein cholesterol (HDL-C) and testosterone fixations, yet the relationship is as yet hazy and questionable among the more extensive male populace in the U.S. The target of this review is to survey the relationship between HDL-C focuses and serum testosterone in U.S. grown-up guys. Information for this populace based study were from the Public Wellbeing and Sustenance Assessment Overview (NHANES) traversing 2011-2016. In the wake of barring grown-up guys matured under 18 years of age and without serum testosterone or HDL-C information, the example enveloped 7,804 male subjects. Contrasted and grown-ups introducing standard HDL-C levels, people with lessened HDL-C fixations displayed diminished testosterone levels (P<0.01). In the fundamental univariable direct relapse examination, factors including age, BMI, HDL, hemoglobin, creatinine and uric corrosive were seen to have an opposite relationship with serum testosterone levels. In the multivariate straight relapse examination, lessening serum testosterone related with decreased HDL-C focuses (assessed testosterone rate difference: 0.36% per mg/dL, P<0.01). In responsiveness examinations that prohibited anomaly or outrageous worth, HDL-C level was emphatically related with testosterone focuses. All in all, this cross-sectional review demonstrated a positive linkage between HDL-C levels and serum testosterone focuses in grown-up guys, and further largescale planned examinations are fundamental for approval of the causality between HDL-C and testosterone.
Cellular cytokine therapy and CAR-T cell therapy: Advancements in cancer treatment
Authors: Zhou Zihan
Published: November 2023

This paper presents a comprehensive examination of the current landscape surrounding cellular cytokine therapy and CAR-T cell therapy. The analysis encompasses their existing applications, potential side effects, and the strategic approaches devised to address these adverse reactions. Moreover, the study elucidates the promising prospects associated with these innovative treatment modalities. By delving deep into these critical aspects, the paper offers a nuanced understanding of the significance and challenges that these emerging therapeutic techniques entail. In recent years, the field of cancer treatment has witnessed significant advancements due to breakthroughs like cellular cytokine therapy and CAR-T cell therapy. These therapies hold immense potential in revolutionizing the way we combat cancer. However, along with the promise of these treatments comes the need to address potential side effects. The paper sheds light on the complexities of treatment-induced immune reactions, allergic responses, and non-specific effects that could impact patient well-being. In conclusion, this paper's exploration of cellular cytokine therapy and CAR-T cell therapy provides a robust foundation for comprehending their current applications, potential side effects, and future prospects. The findings outlined in this paper serve as valuable guidance for researchers, clinicians, and policymakers alike, fostering informed decision-making and pioneering advancements in the field of medical science.
Investigating the relationship between obesity and cancer
Authors: You Xinyu,
Published: November 2023

Cancer has been a leading cause of death worldwide, and the role of obesity in cancer has become an alarming issue in recent years. Although the direct mechanism between obesity and cancer remains incompletely understood, the correlation between the carcinogenic disorders caused by obesity and the substantial number of obese patients shows the connection between the two. The chemicals produced from cells during inflammation, known as reactive oxygen species, can damage the DNA of normal cells, potentially causing cancer. Diseases associated with obesity such as Type II diabetes can also lead to inflammation from insulin resistance based on the presence of inflammation markers. This paper reviews connections between obesity and cancer by analyzing peer-reviewed literature over the past 20 years investigating with a focus on the mechanism of the carcinogenic disorders caused by obesity.
The effects of media use on substance abuse among U.S. adolescents
Authors: Wang Hanning
Published: November 2023

This paper mainly explores the current situation and the effects of substance abuse among U.S. adolescents, with a focus on the effects of media use on substance abuse in the youth, which has drawn material attention in recent years considering the healthy development of adolescents. The United States' high substance consumption rates and increasing overdose deaths among these young individuals in their early life stages highlight the urgency of addressing this question. By synthesizing a list of related reviews published in recent years, this paper clarifies the acute condition of substance use among U.S. adolescents and gives a brief introduction of its impacts as well as the medical treatments or interventions in practice. Furthermore, this paper finds both positive and negative roles of media in the act of abusing in this certain age group by reviewing previous studies. This paper can provide a comprehensive and neutral perspective on this issue to all.
Exploring drug discovery and development strategies in the context of monkeypox: A comprehensive investigation
Authors: Han Yuxin
Published: November 2023

Monkeypox is a rare but potentially serious viral infection that has re-emerged as a major public health problem due to recent outbreaks and the increased likelihood of zoonotic transmission. This review delves into the dynamic landscape of monkeypox drug discovery and drug development, revealing the multifaceted challenges and remarkable progress in the fight against this evolving infectious disease. This summary provides a comprehensive overview of ongoing efforts to identify effective antivirals, explore the potential for repurposing medicines, and pioneer innovative therapeutic strategies. As the search for effective treatments gains momentum, the abstract highlights the critical role of collaborative research efforts, the integration of cutting-edge technologies, and the need to adopt a multidisciplinary approach to address monkeypox complexity. In addition, the abstract highlights the critical importance of assessing the current status and future prospects of monkeypox drug development. By analysing the many factors shaping the field, including viral pathogenesis, host immune responses, and viral genetic diversity, this review contributes to a comprehensive understanding of the challenges inherent in addressing monkeypox.
Application of chloroplast genome analysis in plant taxonomy
Authors: Luo Yanan
Published: November 2023

Chloroplasts are important components of plants and photosynthetic organs, which have played an important role in the long history of biological evolution. Because of this, chloroplast genome research has gradually become the focus of plant research. With the further development of biotechnology, it has been found that the information of chloroplast genome structure and sequence is of great value in revealing the origin of species, evolutionary evolution and the relationship between different species. At the same time, chloroplast transformation technology, which has obvious advantages over nuclear transformation, has shown great potential in genetic improvement and the production of biological agents. Chloroplast genome structure and sequence analysis is the foundation of chloroplast transformation. Based on these important roles of chloroplasts, the application of chloroplast genome in plant classification, variation and distribution analysis was discussed in this paper. At the same time, the current analysis and research methods were summarized and briefly introduced according to different objectives. According to this study, ISSR marker analysis, DNA barcoding technology and high-throughput sequencing technology are still the main biogenic analysis methods for chloroplast gene analysis, and chloroplast transformation is the focus of future research.
Research of effects of video games on sleep health and cognitive ability
Authors: Judge Ella
Published: November 2023

As a new wave of innovative entertainment and media, video games are particularly well-liked among teenagers and young adults, and recent trends show a sharp rise in the amount of time spent playing them. In the modern digital era, video games' pervasive reach has prompted a growing interest in understanding their significant impacts when used continuously. The present paper further delves into the intricate effects of video games on sleep performance, cognitive abilities, and physical well-being, offering a comprehensive exploration of the multifaceted and complex relationship between video games and human health. Specifically, it explores video games' consequences on bodily health, sleeping, and cognitive function through explorations of different research papers and studies conducted. Its found that video games can result in decreased time spent in REM sleep and changes in circadian rhythm. Along with this, prolonged exposure can result in sleep deprivation which can lead to long-term physiological effects on the human body. Video games can both harm and benefit the human physique, as use can aid in increasing fitness in children but chronic use may result in muscle injury and correlate with higher body fat. Many studies found that video game emotional intelligence, behavior, and executive functions in active users.
Explore the potential triggers to binge eating episode
Authors: Zhang Wenxuan
Published: November 2023

Apart from the manifestation within the eating disorder framework, binge eating is also considered as a maladaptive eating behaviour that can occur to individuals without a formal diagnosis of eating disorder. By reviewing recent empirical literatures, negative emotions, body-image, perfectionism, and dieting seem to emerge as primary triggers to binge eating episode. Specially, negative emotions have been extensively discussed and believed to play a pivotal role in triggering the onset of binge eating. Body image and the trait perfectionism tend to be interrelated and mutually reinforced, increasing the risk for binge eating. Lastly, the effect of dieting seems to be relatively ambiguous, as it has been shown to be confounded by multiple factors, indicative of an indirect effect on binge eating. Although limitations were acknowledged, the findings of the present study still provided a comprehensive insight into the potential triggers to binge eating among the subgroup of people without eating disorders.
Analysis of the effects of the ketogenic diet on diabetes
Authors: Yan Haojun
Published: November 2023

In recent years, there has been a notable rise in the occurrence and prevalence of both type 1 and type 2 diabetes worldwide. This increase can be attributed to the social and economic progress experienced by countries, leading to improved living standards for residents. Consequently, diabetes has emerged as a significant societal concern, posing a threat to global population health. As a result, governments and relevant authorities have directed their attention towards addressing this issue. Diabetes is a prevalent and often occurring condition that is typically managed with pharmacological interventions. However, prolonged drug treatment can lead to adverse effects on the body. In conjunction with adequate exercise and dietary modifications, these lifestyle interventions can offer significant assistance in the management of diabetes. This paper employs a comprehensive evaluation of existing literature to present a summary of the utilization of the ketogenic diet as an adjunctive therapy for diabetes. The objective is to examine the effects of the ketogenic diet on diabetes and offer a point of reference for future research endeavors.
Direct-acting antiviral agents (DAA) in the management of hepatitis C in a clinical setting: Effectiveness and limitations
Authors: Wang Yixuan
Published: November 2023

Hepatitis C virus (HCV) significantly burdens public healthcare resources and has infected over 73 million people as of 2023. Past treatments for hepatitis C virus relied on ribavirin pegylated interferon. However, this treatment has adverse side effects, such as depression, anemia, etc. At the same time, this method has a low cure rate and poor patient compliance. DAA can not only treat CHC and even cirrhosis, but also play a crucial role in mediating the recovery of immune damage and regulating glucose metabolism in infected patients. In the contemporary approach of HCV, Direct-acting antiviral agents (DAA) resulted in up to 90% cure rates. At the same time, clinical trials showed DAA also provides many benefits to patients during treatment. Still, with the widespread use of DAA, some DAA limitations have also been identified during its use. This article summarizes the benefits and limitations that DAA has demonstrated in the current treatment of HCV.
The effect of creatine on human body
Authors: Ai Jingpeng
Published: November 2023

The impact of creatine on the human body used as supplementation is explored in this research paper, delving into the analysis of the effects of supplementing with creatine on the human body. A naturally occurring amino acid, creatine can be obtained from our diet and is primarily stored in muscle tissues, acting as an essential source of energy metabolism. For ages, athletes have used creatine as a dietary supplement to enhance muscle strength and size, sporting performance, and cognitive functionality, given its critical role in human body. The focal point of this article is the effect that creatine supplementation has on muscle development, cognitive abilities, aging musculoskeletal health, type 2 diabetes, and oxidative stress, as well as the potential negative outcomes. Based on the data, adding creatine to a routine can have advantageous impact on muscle growth, mental function, oxidant pressure, type 2 diabetes, and the effects of aging on bone and joint health. Although creatine supplementation is commonly deemed as safe, it is crucial to exercise caution when consuming large quantities or using it for an extended period, particularly in individuals with pre-existing health conditions. The study concludes that incorporating creatine supplementation into one's routine may prove beneficial for those seeking to enhance their athletic abilities, muscle mass, strength, and overall well-being. Nevertheless, to fully understand, research is required the potential advantages and risks related to creatine supplementation. Furthermore, it is imperative to ascertain the ideal dosages and protocols that would be suitable for diverse populations and varying conditions.
Composing group action to permutation representation
Authors: Liu Ziming
Published: November 2023

A mapping that satisfies two specific axioms provides a common notion of group action. A homomorphism translating from a group to a symmetric group of a certain set can also be used to describe group action. Therefore, any example of the group actions can be stated based on the second equivalent definition, such as the regular action, natural matrix action, coset action, and Z^2 acting on R^2, etc. It is necessary to examine the concepts of the orbit and stabilizer of a group in order to reveal the orbit-stabilizer theorem. After the preparatory work, the orbit-stabilizer theorem can be proved by defining a mapping from the orbit to the stabilizer and then checking that the mapping is well-defined and bijective. To derive Burnsides lemma, it needs to introduce the set of fixed points which is related to the concept of the stabilizer. Through the orbit-stabilizer theorem along with the fact that a set is a disjoint union of orbits, Burnside's lemma can be confirmed. Moreover, it is natural to compose a group action with a linear representation, and then a representation would be obtained, which is permutation representation. Further, one must calculate the character of the permutation representation, the dimension of the fixed subspace, and the dimension of CX^G. Then it can show Burnsides lemma in another way by permutation representation.
Research and application of Chinese remainder theorem
Authors: Luo Qinnan
Published: November 2023

The Chinese remainder theorem (denoted it as " the theorem" in this article) was originally an important theorem in number theory. It played a vital role in the integer solution of the congruence equation in ancient times. With the continuous development of the algebraic system, the theorem naturally has different forms. This paper will show some research and applications based on the theorem. For example, the theorem in polynomial form, the theorem in the form of group theory, the theorem on unitary rings, the theorem on polynomial ring modules, etc. It is not difficult to know that integers and polynomials are special rings, so this the two forms of the theorem are the theorems that can be covered on the unitary ring. In fact, the theorem in the form of group theory is also covered. This paper will elaborate the first three forms of the theorem and give their specific applications.
Inclined photogrammetry data lightweighting techniques
Authors: Hou Wenchao
Published: November 2023

Since contemporary information-retrieval systems rely heavily on the content of titles and abstracts to identify relevant articles in literature searches, great care should be taken in constructing both. Inclined photogrammetry is an emerging surveying and mapping technology with the advantages of real 3D and multi-view angle, but the huge amount of inclined photogrammetry data makes the application scenarios limited, which leads to the high cost of acquiring inclined photogrammetry data. To address this problem, the lightweighting technology of inclined photogrammetric data is studied. Firstly, the characteristics of inclined photogrammetric data are analysed, the key technology of lightweighting inclined photogrammetric data is studied, and the compression algorithm based on the improved triangular mesh model and the compression algorithm based on the regional chunking model are proposed, which solves the problem of the large volume of inclined photogrammetric data and the inconvenience of using it. The experimental results in small-scale mapping show that the lightweighting of inclined photogrammetric data can be effectively achieved based on the improved triangular mesh model compression algorithm and the regional chunking model compression algorithm, and the optimised combination of the improved triangular mesh model compression algorithm and the regional chunking model compression algorithm can effectively achieve the lightweighting of inclined photogrammetric data.
Group theory behind Rubiks Cube
Authors: Qiu Shengqi
Published: November 2023

The Rubiks Cube is a widely recognized puzzle. The mathematics behind the Rubiks Cube is group theory. Group theory studies algebraic structures in mathematics such as groups, rings, and fields. The operation of the Rubiks Cube is rotation, which can be considered an operation of a group. The combination of two rotations of the Rubiks Cube can be considered the association of two operations of a group. The rotations and the combination operation of two rotations form a group called the Rubiks Cube group, and this paper presents the order of this group which is also the quantity of possible valid configurations of the Rubiks Cube. The valid configurations are the configurations that can be reached by a series of rotations from the starting configuration. This paper presents a method to illustrate the configurations of the Rubiks Cube, the requirements for making the configurations valid, and calculate the quantity of possible valid configurations.
Group action and its application on classification of low order groups
Authors: Liang Shuang
Published: November 2023

The classification of finite groups is an important topic in mathematics throughout history of mathematics. The topic of this paper is to use group action as a tool, to classify some special finite groups and some low order groups. First this paper introduces some concepts of group action. Then this paper states and proves some important theorems related to group action. For example, the Sylows theorem, which is very important in this paper. Research has found that, groups of specific order, such as groups whose order are 2p,p^2, pq(p, q are distinct prime numbers), p3(p is prime) can be classified using group action and the technique of semi-direct product, and groups whose order are no more than 15 are classified which can be seen as the special situations of the above ones. But in general, to make classification of a larger range of finite groups, more tools should be introduced.
Research on the group theory based on the perspective of the Rubiks Cube
Authors: Deng Yuhan , Zhuo Yishing
Published: November 2023

With the development of mathematics, more and more fields of study have been created and progressed, it is worth to implement the knowledge into the real life. There is a well-known puzzle called the Rubiks Cube, has many connections to a branch of abstract algebra group theory. Therefore, this paper will discuss how the Rubiks Cube showing the properties from group theory, by introducing basic knowledges of group theory, followed by examples in terms of this intelligent toy. This paper will first introduce the properties of the Rubiks Cube, then move to the construction of its group. Subsequently, the four axioms that form a group are explained. After that, the reasons why the operations of the Rubiks Cube are able to form a group are explained as the examples of those four axioms. It is followed by the concepts in group theory, and provisions of the exemplifications in terms of the Rubiks Cube, such as closure, cyclicity, Cayleys graph. Explaining the group theory from the perspective of the Rubiks Cube provides a tangible channel to learn the intangible knowledges effectively. Learners are able to study these hard knowledges easily by rotating a simple toy and observing the conclusions.
Algorithmic applications and principles of superconducting quantum computers
Authors: Hui Siyu
Published: November 2023

Nowadays, with the continuous progress of science and technology, the role of quantum computers has received more attention and gradually become a part of national strategies. Many countries, such as the United States, China, and Japan, have invested a lot of resources in research and development, striving to make breakthroughs and take the lead in this field, in order to meet the coming of the future computing era. Superconducting quantum computers are the most widely used computers at the moment. Based on the introduction of Josephson junction, the physical principle of superconducting quantum computers, this paper analyses the advantages and disadvantages of multiple quantum bits as well as the algorithms of various quantum gates in superconducting quantum computers. Moreover, the author also looks forward to the development of the related technologies of superconducting quantum computers. Finally, corresponding suggestions are put forward for some current problems.