bluuebunny/crossref_metadata_2025 huggingface dataset:
Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
Authors: Gui Wenfang , Hole Mikal Jacob , Molinaro Antonio , Edlund Karolina , Jørgensen Kristin K. , Su Huan , Begher-Tibbe Brigitte , Gaßler Nikolaus , Schneider Carolin V. , Muthukumarasamy Uthayakumar , Mohs Antje , Liao Lijun , Jaeger Julius , Mertens Christian J. , Bergheim Ina , Strowig Till , Hengstler Jan G. , Hov Johannes R. , Marschall Hanns-Ulrich , Trautwein Christian , Schneider Kai Markus
Published: June 2023

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of the biliary tree. The majority of PSC patients suffer from concomitant inflammatory bowel disease (IBD), which has been suggested to promote disease development and progression. However, the molecular mechanisms by which intestinal inflammation may aggravate cholestatic liver disease remain incompletely understood. Here, we employ an IBD-PSC mouse model to investigate the impact of colitis on bile acid metabolism and cholestatic liver injury. Unexpectedly, intestinal inflammation and barrier impairment improve acute cholestatic liver injury and result in reduced liver fibrosis in a chronic colitis model. This phenotype is independent of colitis-induced alterations of microbial bile acid metabolism but mediated via hepatocellular NF-κB activation by lipopolysaccharide (LPS), which suppresses bile acid metabolism in-vitro and in-vivo. This study identifies a colitis-triggered protective circuit suppressing cholestatic liver disease and encourages multi-organ treatment strategies for PSC.
Copper-catalyzed asymmetric C(sp3)-H cyanoalkylation of glycine derivatives and peptides
Authors: Qi Rupeng , Chen Qiao , Liu Liangyu , Ma Zijian , Pan Da , Wang Hongying , Li Zhixuan , Wang Chao , Xu Zhaoqing
Published: June 2023

Alkylnitriles play important roles in many fields because of their unique electronic properties and structural characteristics. Incorporating cyanoalkyl with characteristic spectroscopy and reactivity properties into amino acids and peptides is of special interest for potential imaging and therapeutic purposes. Here, we report a copper-catalyzed asymmetric cyanoalkylation of C(sp3)-H. In the reactions, glycine derivatives can effectively couple with various cycloalkanone oxime esters with high enantioselectivities, and the reaction can be applied to the late-stage modification of peptides with good yields and excellent stereoselectivities, which is useful for modern peptide synthesis and drug discovery. The mechanistic studies show that the in situ formed copper complex by the coordination of glycine derivatives and chiral phosphine Cu catalyst can not only mediate the single electronic reduction of cycloalkanone oxime ester but also control the stereoselectivity of the cyanoalkylation reaction.
Thermally stable threshold selector based on CuAg alloy for energy-efficient memory and neuromorphic computing applications
Authors: Zhou Xi , Zhao Liang , Yan Chu , Zhen Weili , Lin Yinyue , Li Le , Du Guanlin , Lu Linfeng , Zhang Shan-Ting , Lu Zhichao , Li Dongdong
Published: June 2023

As a promising candidate for high-density data storage and neuromorphic computing, cross-point memory arrays provide a platform to overcome the von Neumann bottleneck and accelerate neural network computation. In order to suppress the sneak-path current problem that limits their scalability and read accuracy, a two-terminal selector can be integrated at each cross-point to form the one-selector-one-memristor (1S1R) stack. In this work, we demonstrate a CuAg alloy-based, thermally stable and electroforming-free selector device with tunable threshold voltage and over 7 orders of magnitude ON/OFF ratio. A vertically stacked 64 × 64 1S1R cross-point array is further implemented by integrating the selector with SiO2-based memristors. The 1S1R devices exhibit extremely low leakage currents and proper switching characteristics, which are suitable for both storage class memory and synaptic weight storage. Finally, a selector-based leaky integrate-and-fire neuron is designed and experimentally implemented, which expands the application prospect of CuAg alloy selectors from synapses to neurons.
GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults
Authors: Palmer Christine D. , Scallan Ciaran D. , Kraemer Tardif Lauren D. , Kachura Melissa A. , Rappaport Amy R. , Koralek Daniel O. , Uriel Alison , Gitlin Leonid , Klein Joshua , Davis Matthew J. , Venkatraman Harshni , Hart Meghan G. , Jaroslavsky Jason R. , Kounlavouth Sonia , Marrali Martina , Nganje Charmaine N. , Bae Kyounghwa , Yan Tiffany , Leodones Katharyn , Egorova Milana , Hong Sue-Jean , Kuan Jenchun , Grappi Silvia , Garbes Pedro , Jooss Karin , Ustianowski Andrew
Published: June 2023

SARS-CoV-2 has resulted in high levels of morbidity and mortality world-wide, and severe complications can occur in older populations. Humoral immunity induced by authorized vaccines wanes within 6 months, and frequent boosts may only offer transient protection. GRT-R910 is an investigational self-amplifying mRNA (samRNA)-based SARS-CoV-2 vaccine delivering full-length Spike and selected conserved non-Spike T cell epitopes. This study reports interim analyses for a phase I open-label dose-escalation trial evaluating GRT-R910 in previously vaccinated healthy older adults (NCT05148962). Primary endpoints of safety and tolerability were assessed. Most solicited local and systemic adverse events (AEs) following GRT-R910 dosing were mild to moderate and transient, and no treatment-related serious AEs were observed. The secondary endpoint of immunogenicity was assessed via IgG binding assays, neutralization assays, interferon-gamma ELISpot, and intracellular cytokine staining. Neutralizing antibody titers against ancestral Spike and variants of concern were boosted or induced by GRT-R910 and, contrasting to authorized vaccines, persisted through at least 6 months after the booster dose. GRT-R910 increased and/or broadened functional Spike-specific T cell responses and primed functional T cell responses to conserved non-Spike epitopes. This study is limited due to small sample size, and additional data from ongoing studies will be required to corroborate these interim findings.
Changes in China’s river water quality since 1980: management implications from sustainable development
Authors: Zhang Hanxiao , Cao Xianghui , Huo Shouliang , Ma Chunzi , Li Wenpan , Liu Yong , Tong Yingdong , Wu Fengchang
Published: June 2023

Human activities and climate change threaten water quality in China’s rivers. We simulated the monthly concentrations of riverine total nitrogen (TN), ammonia-nitrogen (NH3-N), total phosphorus (TP), and chemical oxygen demand (CODMn) in 613 sub-watersheds of the nation’s 10 major river basins during the 1980–2050 period based on a 16-year (2003–2018) monitoring dataset using the stacking machine-learning models. The results showed that water quality improved markedly, except for the TN concentration, which was probably due to the lack of a TN control target and assessment system. Quantitative analysis indicated that anthropogenic factors were the primary controls compared with climatic drivers and geographical drivers for TN, TP, and NH3-N concentrations. On the basis of all 17 sustainable development goals (SDGs) relevant to water quality in China, the water resources, water environment, aquatic ecology and water security should be considered collectively to achieve improvements in the ecological status of China’s rivers.
Circadian desynchronization disrupts physiological rhythms of prefrontal cortex pyramidal neurons in mice
Authors: Roberts Brandon L. , Karatsoreos Ilia N.
Published: June 2023

Disruption of circadian rhythms, such as shift work and jet lag, are associated with negative physiological and behavioral outcomes, including changes in affective state, learning and memory, and cognitive function. The prefrontal cortex (PFC) is heavily involved in all of these processes. Many PFC-associated behaviors are time-of-day dependent, and disruption of daily rhythms negatively impacts these behavioral outputs. Yet how disruption of daily rhythms impacts the fundamental function of PFC neurons, and the mechanism(s) by which this occurs, remains unknown. Using a mouse model, we demonstrate that the activity and action potential dynamics of prelimbic PFC neurons are regulated by time-of-day in a sex specific manner. Further, we show that postsynaptic K+ channels play a central role in physiological rhythms, suggesting an intrinsic gating mechanism mediating physiological activity. Finally, we demonstrate that environmental circadian desynchronization alters the intrinsic functioning of these neurons independent of time-of-day. These key discoveries demonstrate that daily rhythms contribute to the mechanisms underlying the essential physiology of PFC circuits and provide potential mechanisms by which circadian disruption may impact the fundamental properties of neurons.
Neem leaf powder (Azadirachta indica) mitigates oxidative stress and pathological alterations triggered by lead toxicity in Nile tilapia (Oreochromis niloticus)
Authors: Abu-Elala Nermeen M. , Khattab Marwa S. , AbuBakr Huda O. , Helmy Samah , Hesham Ahmed , Younis Nehal A. , Dawood Mahmoud A. O. , El Basuini Mohammed F.
Published: June 2023

This study investigated the clinical and pathological symptoms of waterborne lead toxicity in wild Nile tilapia collected from a lead-contaminated area (the Mariotteya Canal: Pb = 0.6 ± 0.21 mg L−1) and a farmed fish after 2 weeks of experimental exposure to lead acetate (5–10 mg L−1) in addition to evaluating the efficacy of neem leaf powder (NLP) treatment in mitigating symptoms of lead toxicity. A total of 150 fish (20 ± 2 g) were alienated into five groups (30 fish/group with three replicates). G1 was assigned as a negative control without any treatments. Groups (2–5) were exposed to lead acetate for 2 weeks at a concentration of 5 mg L−1 (G2 and G3) or 10 mg L−1 (G4 and G5). During the lead exposure period, all groups were reared under the same conditions, while G3 and G5 were treated with 1 g L−1 NLP. Lead toxicity induced DNA fragmentation and lipid peroxidation and decreased the level of glutathione and expression of heme synthesis enzyme delta aminolaevulinic acid dehydratase (ALA-D) in wild tilapia, G2, and G4. NLP could alleviate the oxidative stress stimulated by lead in G3 and showed an insignificant effect in G5. The pathological findings, including epithelial hyperplasia in the gills, edema in the gills and muscles, degeneration and necrosis in the liver and muscle, and leukocytic infiltration in all organs, were directly correlated with lead concentration. Thus, the aqueous application of NLP at 1 g L−1 reduced oxidative stress and lowered the pathological alterations induced by lead toxicity.
Mechanical properties of additively manufactured zirconia with alumina air abrasion surface treatment
Authors: Yoo Lee-Gang , Pang Nan-Sim , Kim So-Hyun , Jung Bock-Young
Published: June 2023

This study aimed to evaluate the mechanical properties of zirconia fabricated using additive manufacturing technology and compare them to those of zirconia fabricated using subtractive manufacturing technology. Sixty disc-shaped specimens were fabricated for the additive (n = 30) and subtractive manufacturing groups (n = 30), and each group was divided into two subgroups according to their air-abrasion surface treatment: control (n = 15) and air-abrasion groups (n = 15). Mechanical properties including the flexural strength (FS), Vickers hardness, and surface roughness were determined, and the values were analyzed by one-way ANOVA and Tukey’s post hoc test (α = 0.05). X-ray diffraction and scanning electron microscopy were used for phase analysis and surface topography evaluation, respectively. The SMA group exhibited the highest FS (1144.97 ± 168.1 MPa), followed by the SMC (944.58 ± 141.38 MPa), AMA (905.02 ± 111.38 MPa), and AMC groups (763.55 ± 68.69 MPa). The Weibull distribution showed the highest scale value (1213.55 MPa) in the SMA group, with the highest shape value in the AMA group (11.69). A monoclinic peak was not detected in both the AMC and SMC groups, but after air abrasion, the monoclinic phase content ($${\mathrm{X}}_{\mathrm{m}}$$

X
m

) reached 9% in the AMA group, exceeding that in the SMA group (7%). The AM groups exhibited statistically lower FS values than those of the SM groups under the same surface treatment (p < 0.05). Air-abrasion surface treatment increased the monoclinic phase content and FS (p < 0.05) in both the additive and subtractive groups, while it increased the surface roughness (p < 0.05) only in the additive group and did not affect the Vickers hardness in either group. For zirconia manufactured using additive technology, the mechanical properties are comparable to those of zirconia manufactured using subtractive technology.
Comparative mitogenome analyses of twelve non-biting flies and provide insights into the phylogeny of Chironomidae (Diptera: Culicomorpha)
Authors: Fang Xiangliang , Wang Xinhua , Mao Bin , Xiao Yunli , Shen Mi , Fu Yue
Published: June 2023

The family Chironomidae is represented by seven subfamilies in China, among which Chironominae and Orthocladiinae are the most diverse. To gain a better understanding of the architecture and evolution of the mitogenomes of Chironomidae, we sequenced mitogenomes of twelve species (including two published species) of the two subfamilies Chironominae and Orthocladiinae, and comparative mitogenomic analyses were performed. Thus, we identified highly conserved genome organization of twelve species with regard to genome content, nucleotide and amino acid composition, codon usage, and gene characteristics. TheKa/Ksvalues of most protein-coding genes were far smaller than 1, indicating that these genes were evolving under purifying selection. Phylogenetic relationships between the family Chironomidae were reconstructed using 23 species representing six subfamilies, based on protein-coding genes and rRNAs using Bayesian Inference and Maximum Likelihood. Our results suggested the following relationship within the Chironomidae: (Podonominae + Tanypodinae) + (Diamesinae + (Prodiamesinae + (Orthocladiinae + Chironominae))). This study contributes to the mitogenomic database of Chironomidae, which will be significant for studing the mitogenome evolution of Chironomidae.
Kimberlite eruptions driven by slab flux and subduction angle
Authors: Mather Ben R. , Müller R. Dietmar , Alfonso Christopher P. , Seton Maria , Wright Nicky M.
Published: June 2023

Kimberlites are sourced from thermochemical upwellings which can transport diamonds to the surface of the crust. The majority of kimberlites preserved at the Earth’s surface erupted between 250 and 50 million years ago, and have been attributed to changes in plate velocity or mantle plumes. However, these mechanisms fail to explain the presence of strong subduction signatures observed in some Cretaceous kimberlites. This raises the question whether there is a subduction process that unifies our understanding of the timing of kimberlite eruptions. We develop a novel formulation for calculating subduction angle based on trench migration, convergence rate, slab thickness and density to connect the influx of slab material into the mantle with the timing of kimberlite eruptions. We find that subduction angles combined with peaks in slab flux predict pulses of kimberlite eruptions. High rates of subducting slab material trigger mantle return flow that stimulates fertile reservoirs in the mantle. These convective instabilities transport slab-influenced melt to the surface at a distance inbound from the trench corresponding to the subduction angle. Our deep-time slab dip formulation has numerous potential applications including modelling the deep carbon and water cycles, and an improved understanding of subduction-related mineral deposits.
Computational simulation for MHD peristaltic transport of Jeffrey fluid with density-dependent parameters
Authors: Ibrahim M. G. , Abou-zeid M. Y.
Published: June 2023

This study aimed to give a new theoretical recommendation for non-dimensional parameters depending on the fluid temperature and concentration. This suggestion came from the fact of fluid density may change with the fluid temperature ($$\theta $$
θ
) and concentration ($$\varphi $$
φ
). So, a newly released mathematical form of Jeffrey fluid with peristalsis through the inclined channel is constructed. The problem model defines a mathematical fluid model which converts using non-dimensional values. A sequentially used technique called the Adaptive shooting method for finding the problem solutions. Axial velocity behavior has become a novel concern to Reynolds number. In contradiction to different values of parameters, the temperature and concentration profiles are designated/sketched. The results show that the high value of the Reynolds number acts as a fluid temperature damper, while it boosts the concentration of the fluid particle. The non-constant fluid density recommendation makes the Darcy number controls with a fluid velocity which is virtually significant in drug carries applications or blood circulation systems. To verify the obtained results, a numerical comparison for obtained results has been made with a trustful algorithm with aid of AST using wolfram Mathematica version 13.1.1.
Relationships of the arcuate fasciculus and nigrostriatal tract with language ability in intracerebral hemorrhage using a diffusion tensor imaging
Authors: Jang Sung Ho , Yeo Sang Seok , Cho Min Jye
Published: June 2023

We investigated the relationships of the arcuate fasciculus (AF) and the nigrostriatal tract (NST) with the language ability in patients with putaminal hemorrhage (PH) in the dominant hemisphere, using diffusion tensor tractography (DTT). Twenty-seven consecutive right-handed patients with PH and 27 age- and sex-matched normal control subjects were recruited. The aphasia quotient (AQ) score was used to evaluate the language ability at the early stage (within six weeks after onset). The fractional anisotropy (FA) value and tract volume (TV) of the ipsilesional AF and the ipsilesional NST were measured. The FA values and TVs of the ipsilesional AF and the ipsilesional NST of the patient group were lower than those of the control group (p < 0.05). The AQ score showed no significant correlation with the FA values of the ipsilesional AF and the ipsilesional NST (p > 0.05). By contrast, the AQ score showed a strong positive correlation with the TV of the ipsilesional AF (r = 0.868,p < 0.05). In addition, the AQ score revealed a moderate positive correlation with the TV of the ipsilesional NST (r = 0.577,p < 0.05). The states of the ipsilesional AF and the ipsilesional NST were closely related to the language ability at the early stages in patients with PH in the dominant hemisphere. Furthermore, the ipsilesional AF was more closely related to the language ability than the ipsilesional NST.
A deep learning predictive model for public health concerns and hesitancy toward the COVID-19 vaccines
Authors: Farghaly Heba Mamdouh , Gomaa Mamdouh M. , Elgeldawi Enas , Askr Heba , Elshaier Yaseen A. M. M. , Ella Hassan Aboul , Darwish Ashraf , Hassanien Aboul Ella
Published: June 2023

Throughout the pandemic era, COVID-19 was one of the remarkable unexpected situations over the past few years, but with the decentralization and globalization of efforts and knowledge, a successful vaccine-based control strategy was efficiently designed and applied worldwide. On the other hand, excused confusion and hesitation have widely impacted public health. This paper aims to reduce COVID-19 vaccine hesitancy taking into consideration the patient’s medical history. The dataset used in this study is the Vaccine Adverse Event Reporting System (VAERS) dataset which was created as a corporation between the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) to gather reported side effects that may be caused by PFIEZER, JANSSEN, and MODERNA vaccines. In this paper, a Deep Learning (DL) model has been developed to identify the relationship between a certain type of COVID-19 vaccine (i.e. PFIEZER, JANSSEN, and MODERNA) and the adverse reactions that may occur in vaccinated patients. The adverse reactions under study are the recovery condition, possibility to be hospitalized, and death status. In the first phase of the proposed model, the dataset has been pre-proceesed, while in the second phase, the Pigeon swarm optimization algorithm is used to optimally select the most promising features that affect the performance of the proposed model. The patient’s status after vaccination dataset is grouped into three target classes (Death, Hospitalized, and Recovered). In the third phase, Recurrent Neural Network (RNN) is implemented for both each vaccine type and each target class. The results show that the proposed model gives the highest accuracy scores which are 96.031% for the Death target class in the case of PFIEZER vaccination. While in JANSSEN vaccination, the Hospitalized target class has shown the highest performance with an accuracy of 94.7%. Finally, the model has the best performance for the Recovered target class in MODERNA vaccination with an accuracy of 97.794%. Based on the accuracy and the Wilcoxon Signed Rank test, we can conclude that the proposed model is promising for identifying the relationship between the side effects of COVID-19 vaccines and the patient’s status after vaccination. The study displayed that certain side effects were increased in patients according to the type of COVID-19 vaccines. Side effects related to CNS and hemopoietic systems demonstrated high values in all studied COVID-19 vaccines. In the frame of precision medicine, these findings can support the medical staff to select the best COVID-19 vaccine based on the medical history of the patient.
New findings on choroidal features in healthy people by ultra-widefield swept-source optical coherence tomography angiography
Authors: Liu Xinyue , Chen Sizhu , Leng Hongmei , Wang Yiya , Liu Yi , Shen Yadan , Liu Sanmei , Yi Hangjin , Li Jie , Zhong Jie
Published: June 2023

To evaluate the distribution of choroidal thickness (CT) and its trend with age in healthy people using 120° ultra-wide field swept-source optical coherence tomography angiography (UWF SS-OCTA). In this cross-sectional observational study, healthy volunteers underwent single imaging of the fundus with UWF SS-OCTA at a field of view (FOV) of 120° (24 mm × 20 mm) centered on the macula. The characteristics of CT distribution in different regions and its changes with age were analyzed. A total of 128 volunteers with a mean age of 34.9 ± 20.1 years and 210 eyes were enrolled in the study. The thickest mean choroid thickness (MCT) was located at the macular region and supratemporal region, followed by the nasal side of the optic disc, and thinnest below the optic disc. The maximum MCT was: 213.40 ± 36.65 μm for the group aged 20–29, and the minimum MCT was: 162.11 ± 31.96 μm for the group aged ≥ 60. After the age of 50, MCT was significantly and negatively correlated decreased with age (r = − 0.358, p = 0.002), and the MCT in the macular region decreased more remarkably compared to other regions. The 120° UWF SS-OCTA can observe the distribution of choroidal thickness in the range of 24 mm × 20 mm and its variation with age. It was revealed that MCT decreased more rapidly in the macular region relative to other regions after 50 years old.
Multiscale (microscopic to remote sensing) preliminary exploration of auriferous-uraniferous marbles: A case study from the Egyptian Nubian Shield
Authors: Shebl Ali , Hamdy Mohamed
Published: June 2023

Since their recent first record within the Egyptian Nubian Shield, auriferous and uraniferous marbles (Au = 0.98–2.76 g/t; U = 133–640 g/t) have rarely been addressed, despite not only their probable economic importance but also the fact that it is a new genetic style of gold and uranium mineralization in the Nubian Shield rocks. This is mainly attributed to the inadequate localization of these marbles within harsh terrains, as well as the cost and time spent with conventional fieldwork for their identification compared to the main lithological components of the Nubian Shield. On the contrary, remote sensing and machine learning techniques save time and effort while introducing reliable feature identification with reasonable accuracy. Consequently, the current research is an attempt to apply the well-known machine learning algorithm (Support vector Machine—SVM) over Sentinel 2 remote sensing data (with a spatial resolution of up to 10 m) to delineate the distribution of auriferous-uraniferous marbles in the Barramiya-Daghbagh district (Eastern Desert of Egypt), as a case study from the Nubian Shield. Towards better results, marbles were accurately distinguished utilizing ALOS PRISM (2.5 m) pan-sharpened Sentinel 2 data and well-known exposures during fieldwork. With an overall accuracy of more than 90%, a thematic map for auriferous-uraniferous marbles and the major rock units in the Barramiya-Daghbagh district was produced. Marbles are spatially related to ophiolitic serpentinite rocks, as consistent with their genesis within the Neoproterozoic oceanic lithosphere. Field and petrographic investigations have confirmed the newly detected Au and U-bearing zones (impure calcitic to impure dolomitic marbles in Wadi Al Barramiya and Wadi Daghbagh areas and impure calcitic marble in Gebel El-Rukham area). Additionally, X-ray diffraction (XRD), back-scattered electron images (BSEIs), and Energy Dispersive X-ray spectroscopy (EDX) results were integrated to verify our remote sensing results and petrographic investigations. Different times of mineralization are indicated, ranging from syn-metamorphism (gold in Wadi Al Barramiya and Gebel El-Rukham) to post-metamorphism (gold in Wadi Daghbagh and uranium in all locations). Based on the application of geological, mineralogical, machine learning and remote sensing results for the construction of a preliminary exploration model of the auriferous-uraniferous marble in the Egyptian Nubian Shield, we recommend a detailed exploration of Au and U-bearing zones in Barramiya-Dghbagh district and applying the adopted approach to other districts of similar geological environments.
Genetic least square estimation approach to wind power curve modelling and wind power prediction
Authors: Wang Zhiming , Wang Xuan , Liu Weimin
Published: June 2023

Wind power curve (WPC) is an important index of wind turbines, and it plays an important role in wind power prediction and condition monitoring of wind turbines. Motivated by model parameter estimation of logistic function in WPC modelling, aimed at the problem of selecting initial value of model parameter estimation and local optimum result, based on the combination of genetic algorithm and least square estimation method, a genetic least square estimation (GLSE) method of parameter estimation is proposed, and the global optimum estimation result can be obtained. Six evaluation indices including the root mean square error, the coefficient of determinationR2, the mean absolute error, the mean absolute percentage error, the improved Akaike information criterion and the Bayesian information criterion are used to select the optimal power curve model in the different candidate models, and avoid the model’s over-fitting. Finally, to predict the annual energy production and output power of wind turbines, a two-component Weibull mixture distribution wind speed model and five-parameter logistic function power curve model are applied in a wind farm of Jiangsu Province, China. The results show that the GLSE approach proposed in this paper is feasible and effective in WPC modelling and wind power prediction, which can improve the accuracy of model parameter estimation, and five-parameter logistic function can be preferred compared with high-order polynomial and four-parameter logistic function when the fitting accuracy is close.
Effects of a 4-week plyometric training on activity patterns during different phases of one-leg drop jump with focus on jump height
Authors: Ahmadabadi Somayeh , Rjabi Hamid , Gharakhanlou Reza , Talebian Saeed , Basereh Aref
Published: June 2023

Athletic women have shown a higher risk of ACL injury during jump landing compared to men. Plyometric training can be an alternative way to minimize the risk of knee injuries via the changed muscle activity patterns. Hence, the aim of this study was to determine the effects of a 4-week plyometric training program on the muscle activity pattern in different phases of one-leg drop jump in active girls. Active girls were randomly allocated into 2 groups (Plyometric training = 10, Control group = 10) where the plyometric training group (PTG) performed 60 min exercises, 2 sessions/1 week for 4 weeks while the control group (CG) had their daily activity. In the pre to post test, the sEMG was recorded from the Rectus Femoris (RF), Biceps Femoris (BF), Medial Gastrocnemius (GaM), and Tibialis Anterior (TA) muscles of the dominant leg during the Preparatory phase (PP), Contact Phase (CP), Flight Phase (FP) of one-leg drop jump. Electromyography variables (Signal amplitude, Maximum activity, Time to peak (TTP), Onset and activity time and Order muscle activity) and Ergo jump variables (Time of preparatory phase (TPP), Time of contact phase (TCP), Time of flight (jump height) phase (TFP), and Explosive power were analyzed. The Univariate ANCOVA test showed a significant difference between the two groups in Activity Time, whilst adjusting for pre-test as a Covariate, only in TA muscle (F(1,17) = 5.09, p = 0.038, η2 = 0.230). In PTG. TA (− 15%), GaM (− 19%), and BF muscles (− 9%) started their activity earlier while there was no significant difference between the two groups at the Onset time. TTP of RF was significantly different between the 2 groups only in the PR phase (0.216 ± 0.07 vs 0.153 ± 0.09 s) (p = 0.049, 95% CI = 0.001, 0.127). Results of the present study suggest that a 4-week plyometric training can improve the stability of leg joints via earlier recruitment of muscles and change activity patterns in lower limb muscles. It also recommends that the preparatory phase before landing be considered an important stage in preventing sports injuries in a training program.
Achieving outstanding mechanical/bonding performances by epoxy nanocomposite as concrete–steel rebar adhesive using silane modification of nano SiO2
Authors: Ghamarpoor Reza , Jamshidi Masoud , Mohammadpour Majid
Published: June 2023

Anchoring steel rebar in concrete structures is a common method in the building and construction industry. This research focuses on improving the mechanical/bonding properties of the prepared epoxy nanocomposite adhesive using surface treatment of SiO2 nano fillers by glycidoxypropyltrimethoxysilane (GPTMS). For this purpose, the nano silica particles were silanized via a facile sol–gel method at silane concentrations of 1, 5, 10 and 20X (i.e. X is stoichiometric silane concentration). The nanoparticles were characterized carefully by FTIR, TGA, XRD and XPS techniques. It was found that the highest GPTMS grafting ratio was obtained at silane concentration of 10X. The pure and silanized nanoparticles were added to a two-pack epoxy resin and were compared for tensile and compressive properties. It was found that surface modification of nano silica caused improvement in the strength, modulus, compressive strength and compressive modulus by 56, 81, 200 and 66% compared to the pristine epoxy adhesive and also 70, 20, 17 and 21% compared to the pure nano silica containing adhesive. It also caused 40 and 25% improvement in the pullout strength, 33 and 18% enhancement in the pullout displacement and 130 and 50% in adhesion energy compared to the pristine and raw silica-containing adhesives, respectively.
Characteristics of urban park recreation and health during early COVID-19 by on-site survey in Beijing
Authors: Cao Lei , Sun Yan , Beckmann-Wübbelt Angela , Saha Somidh
Published: June 2023

The positive health effects of green space have received increasing attention, however, on-site surveys and city-level research to reveal the relationship between urban park recreation and urbanite health in metropolitan areas during a post-pandemic period are lacking. We conducted an on-site survey using a questionnaire with 225 respondents from 22 urban parks distributed across the metropolitan area of Beijing during the early COVID-19 eased period with another 1346 respondents in 2021 to make verification. We identified factors that could influence public perceptions of park quality and human health (i.e., physical, mental, and social health) and revealed gender differences in perceptions of park characteristics. The correspondence pattern of perceived urban park quality with social health is distinct from that of physical and mental health. Due to the strict social distancing policy in early COVID-19 period, urban parks in different levels of urbanization environment could exert varied health effects.
Fine scale sampling reveals early differentiation of rhizosphere microbiome from bulk soil in young Brachypodium plant roots
Authors: Acharya Shwetha M , Yee Mon Oo , Diamond Spencer , Andeer Peter F , Baig Nameera F , Aladesanmi Omolara T , Northen Trent R , Banfield Jillian F , Chakraborty Romy
Published: June 2023

For a deeper and comprehensive understanding of the composition and function of rhizosphere microbiomes, we need to focus at the scale of individual roots in standardized growth containers. Root exudation patterns are known to vary along distinct parts of the root even in juvenile plants giving rise to spatially distinct microbial niches. To address this, we analyzed the microbial community from two spatially distinct zones of the developing primary root (tip and base) in young Brachypodium distachyon grown in natural soil using standardized fabricated ecosystems known as EcoFABs as well as in more conventional pot and tubes. 16S rRNA based community analysis showed a strong rhizosphere effect resulting in significant enrichment of several OTUs belonging to Actinobacteria, Bacteroidetes, Firmicutes and Proteobacteria. However, microbial community composition did not differ between root tips and root base or across different growth containers. Functional analysis of bulk metagenomics revealed significant differences between root tips and bulk soil. The genes associated with different metabolic pathways and root colonization were enriched in root tips. On the other hand, genes associated with nutrient-limitation and environmental stress were prominent in the bulk soil compared to root tips, implying the absence of easily available, labile carbon and nutrients in bulk soil relative to roots. Such insights into the relationships between developing root and microbial communities are critical for judicious understanding of plant-microbe interactions in early developmental stages of plants.
A multicenter explanatory survey of patients’ and clinicians’ perceptions of motivational factors in rehabilitation
Authors: Oyake Kazuaki , Yamauchi Katsuya , Inoue Seigo , Sue Keita , Ota Hironobu , Ikuta Junichi , Ema Toshiki , Ochiai Tomohiko , Hasui Makoto , Hirata Yuya , Hida Ayaka , Yamamoto Kenta , Kawai Yoshihiro , Shiba Kiyoto , Atsumi Akihito , Nagafusa Tetsuyuki , Tanaka Satoshi
Published: June 2023

Background

Patient motivation is an important determinant of rehabilitation outcomes. Differences in patients’ and clinicians’ perceptions of motivational factors can potentially hinder patient-centered care. Therefore, we aimed to compare patients’ and clinicians’ perceptions of the most important factors in motivating patients for rehabilitation.

Methods

This multicenter explanatory survey research was conducted from January to March 2022. In 13 hospitals with an intensive inpatient rehabilitation ward, 479 patients with neurological or orthopedic disorders undergoing inpatient rehabilitation and 401 clinicians, including physicians, physical therapists, occupational therapists, and speech-language-hearing therapists, were purposively selected using inclusion criteria. The participants were asked to choose the most important factor motivating patients for rehabilitation from a list of potential motivational factors.

Results

Here we show that realization of recovery, goal setting, and practice related to the patient’s experience and lifestyle are the three factors most frequently selected as most important by patients and clinicians. Only five factors are rated as most important by 5% of clinicians, whereas nine factors are selected by 5% of patients. Of these nine motivational factors, medical information (p < 0.001; phi = −0.14; 95% confidence interval = −0.20 to −0.07) and control of task difficulty (p = 0.011; phi = −0.09; 95% confidence interval = −0.16 to −0.02) are selected by a significantly higher proportion of patients than clinicians.

Conclusions

These results suggest that when determining motivational strategies, rehabilitation clinicians should consider individual patient preferences in addition to using the core motivational factors supported by both parties.
Long term 5G network traffic forecasting via modeling non-stationarity with deep learning
Authors: Yang Yuguang , Geng Shupeng , Zhang Baochang , Zhang Juan , Wang Zheng , Zhang Yong , Doermann David
Published: June 2023

5G cellular networks have recently fostered a wide range of emerging applications, but their popularity has led to traffic growth that far outpaces network expansion. This mismatch may decrease network quality and cause severe performance problems. To reduce the risk, operators need long term traffic prediction to perform network expansion schemes months ahead. However, long term prediction horizon exposes the non-stationarity of series data, which deteriorates the performance of existing approaches. We deal with this problem by developing a deep learning model, Diviner, that incorporates stationary processes into a well-designed hierarchical structure and models non-stationary time series with multi-scale stable features. We demonstrate substantial performance improvement of Diviner over the current state of the art in 5G network traffic forecasting with detailed months-level forecasting for massive ports with complex flow patterns. Extensive experiments further present its applicability to various predictive scenarios without any modification, showing potential to address broader engineering problems.
Production of mixed element actinide reference particulates to support nuclear safeguards using THESEUS, an aerosol-based particulate synthetic methodology
Authors: Naes Benjamin E. , Scott Spencer , Waldron Abigail , Lawson Seth , Bronikowski Michael G. , Gleaton Laken I. , Smith Ross J. , Wurth Kimberly N. , Tenner Travis J. , Wellons Matthew
Published: June 2023

The THermally Evaporated Spray for Engineered Uniform particulateS (THESEUS) production platform was developed to generate highly uniform mixed actinide oxide particles.
Synthesis of Mn2+:CsPb (Br1−xClx)3perovskite quantum dots in an ambient atmosphere: stability analysis and self-powered photodetector applications
Authors: A Malavika. , Suresh Swapnika , Subramaniam Mohan Raj , Batabyal Sudip K.
Published: June 2023

Mn2+:CsPb(Br1−xClx)3 QDs under UV irradiation over the analysis period and its simulated crystal structure.
Substituent effects on paratropicity and diatropicity in π-extended hexapyrrolohexaazacoronene
Authors: Takase Masayoshi , Takata Toranosuke , Oki Kosuke , Mori Shigeki , Uno Hidemitsu
Published: June 2023

Substituent effects in antiaromatic homoHPHAC+ and aromatic homoHPHAC3+ were investigated by NMR, crystal structure, redox, absorption, and DFT calculation analyses.
Molecularly imprinted polymer coating-assisted CsPbBr3 perovskite quantum dots/TiO2 inverse opal heterojunctions for the photoelectrochemical detection of cholesterol
Authors: Wang Xuan , Lin Fankai , Zhou Xiaoyu , Miao Yunfei , Feng Dongwei , Huang Peng , Ren Mingxing , Geng Lina , Luo Aiqin , Deng Yulin
Published: June 2023

CsPbBr3 based photoelectrochemical sensor constructed here exhibited outstanding sensitivity, selectivity and water stability.
Specific multiplexed detection of mRNA splice variants based on size-coding DNA probes and universal PCR amplification
Authors: Jia Yuting , Wang Honghong , Wang Hui , Wang Fangfang , Gao Kejian , Li Zhengping
Published: June 2023

A specific multiplexed quantification strategy is developed for the detection of mRNA splice variants based on size-coding DNA probes and universal PCR amplification.
From droplets to ions: a comprehensive and consecutive ion formation modelling in atmosphere pressure interface of electrospray ionization mass spectrometry
Authors: Xingliang He , Xing Guo , Mengfan Wu , Fulong Deng , Pengyu Zeng , Zhongjun Zhao , Yixiang Duan
Published: June 2023

In this study, we propose a novel ion formation simulation method for electrospray ionization (ESI) and atmosphere pressure interface (API).
Molecular regulation of electrolytes for enhancing anode interfacial stability in lithium–sulfur batteries
Authors: Zhou Tianhong , Zhao Yan , Fritz Patrick W. , Ashirov Timur , Baster Dominika , El Kazzi Mario , Coskun Ali
Published: June 2023

We addressed the poor interfacial stability of the Li metal anode in Li–S batteries through molecular regulation of electrolytes using arylthiol additives with various numbers of anchoring sites.
A molecular aluminium fulleride
Authors: Lawrence Samuel Ray , Rüffer Tobias , Stasch Andreas , Kretschmer Robert
Published: June 2023

Go-Al! low valent aluminium scores a Hat-trick by converting C60 to a tri-substituted molecular aluminium fulleride.
Asymmetric total synthesis of (+)-propolisbenzofuran B
Authors: Sen Biswajit , Bera Mainak , Singh Maya Shankar , Hajra Saumen
Published: June 2023

The first asymmetric total synthesis of (+)-propolisbenzofuran B is accomplished in 11 steps with an overall yield of 11.9% from three easily accessible substrates.
Erbium oxide nanoplates as a sonosensitizer devoid of photosensitivity
Authors: Dai Yingfan , Yang Ruihao , Marfavi Zeinab , Lv Quanjie , Han Yijun , Sun Kang , Wu Danhong , Tao Ke
Published: June 2023

Er2O3 nanoplates could be a sensitizer for sonodynamic therapy without phototoxicity.
Directly revealing the geometric phase effect of dissociative D2+by two-color strong field photodissociation
Authors: Zhaopeng Sun , Yunquan Liu
Published: June 2023

Momentum distribution of the photodissociation fragments for the linearly polarized two-color (266 nm + 800 nm) synthesized laser field.
The protein environment restricts the intramolecular charge transfer character of the luciferine/luciferase complex
Authors: Mateo-delaFuente Henar , Avagliano Davide , Garavelli Marco , Nogueira Juan J.
Published: June 2023

The effect of the intramolecular and intermolecular degrees of freedom on the electronically excited state properties of the oxyluciferin/luciferase complex is computationally investigated.
Structural isomerism induces pH dependent AIE-coupled ESIPT: an in-depth spectroscopic exploration with application in amine vapor sensing
Authors: Bhattacharyya Arghyadeep , Bhakta Viki , Guchhait Nikhil
Published: June 2023

ESIPT-coupled-AIE phenomenon in 3-(benzo[d]thiazol-2-yl)-4-hydroxy-5-methoxybenzaldehyde (3BTHMB) and its rapid sensing behaviour towards amine vapor in solid state and ratiometric detection of acidic or basic nature of water sample.
Determination of hyper-parameters in the atomic descriptors for efficient and robust molecular dynamics simulations with machine learning forces
Authors: Lin Jianbo , Tamura Ryo , Futamura Yasunori , Sakurai Tetsuya , Miyazaki Tsuyoshi
Published: June 2023

A simple yet reliable scheme for reducing the dimensionality of atomic descriptors is proposed to construct the machine-learning forces for stable and accurate MD simulations.
Imaging rotational energy transfer: comparative stereodynamics in CO + N2 and CO + CO inelastic scattering
Authors: Sun Zhong-Fa , Scheidsbach Roy J. A. , van Hemert Marc C. , van der Avoird Ad , Suits Arthur G. , Parker David H.
Published: June 2023

State-to-state rotational energy transfer of 13CO + N2 inelastic scattering has been studied using the crossed molecular beam method under kinematically equivalent conditions used for 13CO + CO scattering described previously (Science, 369, 307–309).
Correction: Benchmark and performance of long-range corrected time-dependent density functional tight binding (LC-TD-DFTB) on rhodopsins and light-harvesting complexes
Authors: Bold Beatrix M. , Sokolov Monja , Maity Sayan , Wanko Marius , Dohmen Philipp M. , Kranz Julian J. , Kleinekathöfer Ulrich , Höfener Sebastian , Elstner Marcus
Published: June 2023

Correction for ‘Benchmark and performance of long-range corrected time-dependent density functional tight binding (LC-TD-DFTB) on rhodopsins and light-harvesting complexes’ by Beatrix M. Bold et al., Phys. Chem. Chem. Phys., 2020, 22, 10500–10518, https://doi.org/10.1039/C9CP05753F.
Correction: Helium nanodroplets as an efficient tool to investigate hydrogen attachment to alkali cations
Authors: Kollotzek Siegfried , Campos-Martínez José , Bartolomei Massimiliano , Pirani Fernando , Tiefenthaler Lukas , Hernández Marta I. , Lázaro Teresa , Zunzunegui-Bru Eva , González-Lezana Tomás , Bretón José , Hernández-Rojas Javier , Echt Olof , Scheier Paul
Published: June 2023

Correction for ‘Helium nanodroplets as an efficient tool to investigate hydrogen attachment to alkali cations’ by Siegfried Kollotzek et al., Phys. Chem. Chem. Phys., 2023, 25, 462–470, https://doi.org/10.1039/D2CP03841B.
Metallaphotoredox catalysis for sp3C–H functionalizations through hydrogen atom transfer (HAT)
Authors: Zhang Jingchang , Rueping Magnus
Published: June 2023

sp3C–H functionalizations under the combination of photocatalytic HAT and transition metal catalysis.
Harmonizing the growing fluorogenic RNA aptamer toolbox for RNA detection and imaging
Authors: Lu Xiaocen , Kong Kristen Y. S. , Unrau Peter J.
Published: June 2023

The field of fluorogenic RNA aptamers is a burgeoning research area that aims to address the lack of naturally fluorescent RNA molecules for RNA detection and imaging.
Zeolite-based catalysts for oxidative upgrading of methane: design and control of active sites
Authors: Yabushita Mizuho , Osuga Ryota , Yokoi Toshiyuki , Muramatsu Atsushi
Published: June 2023

Various reported active sites in zeolite-based catalysts categorized into three groups in terms of their origin have been overviewed from the viewpoints of their performance, structure, and catalysis.
Stabilization of transition metal heterojunctions inside porous materials for high-performance catalysis
Authors: Zhang Chi , Wang Lei , Wu Chuan-De
Published: June 2023

The developed strategies for stabilizing heterojunctions in different porous materials with improved synergistic effect, catalytic properties and stability are summarized and discussed.
Correction: A submersible probe with in-line calibration and a symmetrical reference element for continuous direct nitrate concentration measurements
Authors: Forrest Tara , Cherubini Thomas , Jeanneret Stéphane , Zdrachek Elena , Damala Polyxeni , Bakker Eric
Published: June 2023

Correction for ‘A submersible probe with in-line calibration and a symmetrical reference element for continuous direct nitrate concentration measurements' by Tara Forrest et al., Environ. Sci.: Processes Impacts, 2023, 25, 519–530, https://doi.org/10.1039/D2EM00341D.
Acid-tolerant Lactiplantibacillus plantarum ZDY2013 shows a colonization niche preference and interacts with enterotoxigenic Bacillus cereus in specific-pathogen-free mice
Authors: Zhang Na , Li Jinmei , Zhan Ying , Wang Kaiming , Zhan Zhongxu , Wei Hua , Zhang Zhihong
Published: June 2023

Lactiplantibacillus plantarum ZDY2013 shows a colonization niche preference and interacts with the food-borne pathogen Bacillus cereus in the complex gut environment.
Overview of CO2 capture and electrolysis technology in molten salts: operational parameters and their effects
Authors: Zhu Qiuji , Zeng Yimin , Zheng Ying
Published: June 2023

Molten salt electrochemical system towards carbon deposition.