bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling Facilitates Silvicultural Decision-Making for Improving the Mitigating Effect of Beech (Fagus Sylvatica L.) Dominated Alpine Forest against Rockfall
Authors: Kajdiž Petra , Diaci Jurij , Rebernik Jernej
Published: June 2015

In southeast Europe, silvicultural measures for improving forest protective effects against rockfall are often based on unsystematic observation and experience. We compared formalised expert assessment of forest protective effects and silvicultural decision-making with an approach supported by modelling (Rockyfor3D, Rockfor.NET, shadow angle method). The case study was conducted in Fagus sylvatica dominated Alpine forests above the regional road leading to the Ljubelj pass, in Slovenia. We analysed rock sources, silent witnesses, forest structure and regeneration. Expert assessment indicated acceptable protection effects of the forest and their decline in the future. Modelling revealed several road sections endangered by rockfalls. It also indicated subtle differences between silvicultural alternatives: current forest, current forest with cable crane lines, selection forest and non-forested slope. This outcome may be due to short transition zones, small rock sizes, low rock source heights and low resolution of the digital elevation model. Modelling requires more initial input than formalised expert assessment but gives spatially explicit results that enable comparison of silvicultural alternatives, coordination of silviculture and forest operations, and delineation of protection forests. Modelling also supported prioritising of silvicultural measures, where the necessity of silvicultural measures increases with increasing rockfall susceptibility and decreasing long-term stability of stands.
Regulation of Water Use in the Southernmost European Fir (Abies pinsapo Boiss.): Drought Avoidance Matters
Authors: Sánchez-Salguero Raúl , Ortíz Cristina , Covelo Felisa , Ochoa Victoria , García-Ruíz Roberto , Seco José , Carreira José , Merino José , Linares Juan
Published: June 2015

The current scenario of global warming has resulted in considerable uncertainty regarding the capacity of forest trees to adapt to increasing drought. Detailed ecophysiological knowledge would provide a basis to forecast expected species dynamics in response to climate change. Here, we compare the water balance (stomatal conductance, xylem water potential, needle osmotic adjustment) of Abies pinsapo, a relict drought-sensitive Mediterranean fir, along an altitudinal gradient. We related these variables to soil water and nutrient availability, air temperature, atmospheric water potential, and vapour pressure deficit during two consecutive years. Our results indicate that A. pinsapo closed stomata rapidly over a very narrow range of soil water availability and atmospheric dryness. This isohydric response during water stress suggests that this relict conifer relied on the plant hormone abscisic acid to maintain closed stomata during sustained drought, instead of needle desiccation to passively drive stomatal closure, needle osmotic adjustment or a plastic response of the xylem to different levels of water availability. Both the soil and foliar nutrient contents suggest that the studied populations are not limited by nutrient deficiencies, and drought was stronger in the warmer low-elevation areas.
PHF6 Degrees of Separation: The Multifaceted Roles of a Chromatin Adaptor Protein
Authors: Todd Matthew , Ivanochko Danton , Picketts David
Published: June 2015

The importance of chromatin regulation to human disease is highlighted by the growing number of mutations identified in genes encoding chromatin remodeling proteins. While such mutations were first identified in severe developmental disorders, or in specific cancers, several genes have been implicated in both, including the plant homeodomain finger protein 6 (PHF6) gene. Indeed, germline mutations in PHF6 are the cause of the Börjeson–Forssman–Lehmann X-linked intellectual disability syndrome (BFLS), while somatic PHF6 mutations have been identified in T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML). Studies from different groups over the last few years have made a significant impact towards a functional understanding of PHF6 protein function. In this review, we summarize the current knowledge of PHF6 with particular emphasis on how it interfaces with a distinct set of interacting partners and its functional roles in the nucleoplasm and nucleolus. Overall, PHF6 is emerging as a key chromatin adaptor protein critical to the regulation of neurogenesis and hematopoiesis.
Therapeutic Community Treatment of an Inmate Population with Substance Use Disorders: Post-Release Trends in Re-Arrest, Re-Incarceration, and Drug Misuse Relapse
Authors: Galassi Alexandra , Mpofu Elias , Athanasou James
Published: June 2015

This systematic literature review maps the evidence for the effectiveness of the therapeutic community interventions (TCI) in reducing re-arrest, re-incarceration or drug misuse following release from prison, including the extent to which these effects are retained over time. The databases searched for the review included PsychINFO, Medline and Scopus and reference lists from relevant articles published between 2007 and 2014. Only quantitative studies that examined the effectiveness of TCI for a prisoner population with drug dependence at the time of initial incarceration were considered. Fourteen studies were identified for inclusion in the review. Three-quarters of the studies reported TCI were effective in reducing rates of re-incarceration. About 70% of studies that examined follow-up rates of drug misuse relapse found TCI effective in reducing rates of drug misuse amongst participants. TCI participation reduced re-arrests events in 55% of the studies. Results suggest TCI effective in the short-term rather than longer term for reducing rates of re-incarceration among participants, and to a slightly lesser extent, drug misuse relapse.
Novel Therapeutic GPCRs for Psychiatric Disorders
Authors: Komatsu Hidetoshi
Published: June 2015

G protein-coupled receptors (GPCRs) are the most common targets of the neuropharmacological drugs in the central nervous system (CNS). GPCRs are activated by manifold neurotransmitters, and their activation in turn evokes slow synaptic transmission. They are deeply involved in multiple neurological and psychiatric disorders such as Parkinson’s disease and schizophrenia. In the brain, the striatum is strongly innervated by the ventral tegmental area (VTA) and plays a central role in manifestation of psychiatric disorders. Recently, anatomical and comprehensive transcriptome analysis of the non-odorant GPCR superfamily revealed that the orphan GPCRs GPR88, GPR6, and GPR52, as well as dopamine D1 and D2 receptors and the adenosine A2a receptor, are the most highly enriched in the rodent striatum. Genetically engineered animal models and molecular biological studies have suggested that these striatally enriched GPCRs have a potential to be therapeutic psychiatric receptors. This review summarizes the current understanding of the therapeutic GPCR candidates for psychiatric disorders.
Improved Identification of Partial Biotinidase Deficiency by Newborn Screening Using Age-Related Enzyme Activity Cutoffs: Reduction of the False-Positive Rate
Authors: VanVleck Nicole , Wolf Barry , Seeterlin Mary , Monaghan Kristin , Stanley Eleanor , Hawkins Harry , Taffe Bonita
Published: June 2015

Background: Biotinidase deficiency is an inherited metabolic disorder that if untreated can result in neurological and cutaneous features. Profound biotinidase deficiency presents in early childhood with severe symptoms, whereas partial biotinidase deficiency can also present with symptoms under times of stress. Symptoms can be prevented by administering biotin. Newborn screening for the disorder is performed using dried blood spots. We examined the relationship between biotinidase activity and age at collection to determine how best to identify infants with partial biotinidase deficiency. Methods: Biotinidase activity in dried blood spots is determined using a quantitative fluorometric assay. Subsequent specimens with biotinidase activity ≤100 U were analyzed by mutation analysis to determine the range of activities expressed in infants with partial biotinidase deficiency. Results: Enzyme activity increased with age, beginning at about three days of age, and rose until plateauing at about 11 days of age. An increase of about 47.6% was observed. A total of 54 specimens had mutation analysis performed identifying 20 affected infants who would not have been identified using the original cutoff activity of 50 U. Conclusion: Biotinidase activity in infants increases with age. Age-related cutoffs assist in selectively identifying infants with partial biotinidase deficiency.
Exploring Water Level Sensitivity for Metropolitan New York during Sandy (2012) Using Ensemble Storm Surge Simulations
Authors: Colle Brian , Bowman Malcolm , Roberts Keith , Bowman M. , Flagg Charles , Kuang Jian , Weng Yonghui , Munsell Erin , Zhang Fuqing
Published: June 2015

This paper describes storm surge simulations made for Sandy (2012) for the Metropolitan New York (NYC) area using the Advanced Circulation (ADCIRC) model forced by the Weather Research and Forecasting (WRF) model. The atmospheric forecast uncertainty was quantified using 11-members from an atmospheric Ensemble Kalman Filter (EnKF) system. A control WRF member re-initialized every 24 h demonstrated the capability of the WRF-ADCIRC models to realistically simulate the 2.83 m surge and 4.40 m storm tide (surge + astronomical tide) above mean lower low water (MLLW) for NYC. Starting about four days before landfall, an ensemble of model runs based on the 11 “best” meteorological predictions illustrate how modest changes in the track (20–100 km) and winds (3–5 m s−1) of Sandy approaching the New Jersey coast and NYC can lead to relatively large (0.50–1.50 m) storm surge variations. The ensemble also illustrates the extreme importance of the timing of landfall relative to local high tide. The observed coastal flooding was not the worst case for this particular event. Had Sandy made landfall at differing times, locations and stages of the tide, peak water levels could have been up to 0.5 m higher than experienced.
Mechanism of Filling and Feeding of Thin-Walled Structures during Gravity Casting
Authors: Li Faguo , Zhang Jiao , Bian Fenggang , Fu Yanan , Xue Yanling , Yin Fucheng , Xie Yu , Xu Yi , Sun Baode
Published: June 2015

The filling and feeding of thin-walled structures in metal castings pose significant difficulties in manufacturing aerospace structural materials. Samples containing 2 mm and 5 mm thin-walled structures were designed to study the kinetics of filling. The microstructural evolution of the solidification of thin-walled structures was studied with synchrotron X-radiation imaging. The formation of dendritic networks and the isotherm profiles of samples of different thickness were examined. The experimental results showed solidification microstructures of 2 mm and 5 mm thin-walled parts containing elongated equiaxed grains and normal equiaxed grains, respectively. The filling and feeding abilities of thin-walled parts were found to depend more on the wall thickness than on the pouring temperature.
Seismic Experimental Study on New-Type Composite Exterior Wallboard with Integrated Structural Function and Insulation
Authors: Ma Shaochun , Jiang Nan
Published: June 2015

In order to evaluate the seismic performance of new-type composite exterior wallboard, a total of six exterior and interior wallboards were incorporated in the experiment of seismic performance. Seismic performance such as the stress process, damage mode, hysteresis and skeleton curve, load-carrying and ductility coefficient, damping and energy dissipation, stiffness degradation as well as material strain of the exterior wallboards were analyzed with emphasis and compared with interior wallboards. Results of the experiment and analysis showed that both interior and exterior wallboards exhibited outstanding seismic performance. Due to the existence of insulation layer and externally bonded single gypsum board, the capacity of elastoplastic deformation and seismic energy dissipation of the exterior wallboards was improved and each seismic performance indicator of the exterior wallboards outperformed the interior wallboards.
Induction of Apoptosis and Antitumor Activity of Eel Skin Mucus, Containing Lactose-Binding Molecules, on Human Leukemic K562 Cells
Authors: Kwak Choong-Hwan , Lee Sook-Hyun , Lee Sung-Kyun , Ha Sun-Hyung , Suh Seok-Jong , Kwon Kyung-Min , Chung Tae-Wook , Ha Ki-Tae , Chang Young-Chae , Lee Young-Choon , Kim Dong-Soo , Chang Hyeun-Wook , Kim Cheorl-Ho
Published: June 2015

For innate immune defense, lower animals such as fish and amphibian are covered with skin mucus, which acts as both a mechanical and biochemical barrier. Although several mucus sources have been isolated and studied for their biochemical and immunological functions, the precise mechanism(s) of action remains unknown. In the present study, we additionally found the eel skin mucus (ESM) to be a promising candidate for use in anti-tumor therapy. Our results showed that the viability of K562 cells was decreased in a dose-dependent manner by treatment with the isolated ESM. The cleaved forms of caspase-9, caspase-3 and poly adenosine diphosphate-ribose polymerase were increased by ESM. The levels of Bax expression and released cytochrome C were also increased after treatment with ESM. Furthermore, during the ESM mediated-apoptosis, phosphorylation levels of ERK1/2 and p38 but not JNK were increased and cell viabilities of the co-treated cells with ESM and inhibitors of ERK 1/2 or p38 were also increased. In addition, treatment with lactose rescued the ESM-mediated decrease in cell viability, indicating lactose-containing glycans in the leukemia cells acted as a counterpart of the ESM for interaction. Taken together, these results suggest that ESM could induce mitochondria-mediated apoptosis through membrane interaction of the K562 human leukemia cells. To the best of our knowledge, this is the first observation that ESM has anti-tumor activity in human cells.
Dynamics of Electrowetting Droplet Motion in Digital Microfluidics Systems: From Dynamic Saturation to Device Physics
Authors: Cui Weiwei , Zhang Menglun , Duan Xuexin , Pang Wei , Zhang Daihua , Zhang Hao
Published: June 2015

A quantitative description of the dynamics of droplet motion has been a long-standing concern in electrowetting research. Although many static and dynamic models focusing on droplet motion induced by electrowetting-on-dielectric (EWOD) already exist, some dynamic features do not fit these models well, especially the dynamic saturation phenomenon. In this paper, a dynamic saturation model of droplet motion on the single-plate EWOD device is presented. The phenomenon that droplet velocity is limited by a dynamic saturation effect is precisely predicted. Based on this model, the relationship between droplet motion and device physics is extensively discussed. The static saturation phenomenon is treated with a double-layer capacitance electric model, and it is demonstrated as one critical factor determining the dynamics of droplet motion. This work presents the relationship between dynamics of electrowetting induced droplet motion and device physics including device structure, surface material and interface electronics, which helps to better understand electrowetting induced droplet motions and physics of digital microfluidics systems.
Triel Bonds, π-Hole-π-Electrons Interactions in Complexes of Boron and Aluminium Trihalides and Trihydrides with Acetylene and Ethylene
Authors: Grabowski Sławomir
Published: June 2015

MP2/aug-cc-pVTZ calculations were performed on complexes of aluminium and boron trihydrides and trihalides with acetylene and ethylene. These complexes are linked through triel bonds where the triel center (B or Al) is characterized by the Lewis acid properties through its π-hole region while π-electrons of C2H2 or C2H4 molecule play the role of the Lewis base. Some of these interactions possess characteristics of covalent bonds, i.e., the Al-π-electrons links as well as the interaction in the BH3-C2H2 complex. The triel-π-electrons interactions are classified sometimes as the 3c-2e bonds. In the case of boron trihydrides, these interactions are often the preliminary stages of the hydroboration reaction. The Quantum Theory of “Atoms in Molecules” as well as the Natural Bond Orbitals approach are applied here to characterize the π-hole-π-electrons interactions.
Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers
Authors: Holland Ashling , Henry Michael , Meleady Paula , Winkler Claudia , Krautwald Mirjam , Brinkmeier Heinrich , Ohlendieck Kay
Published: June 2015

The primary deficiency in the membrane cytoskeletal protein dystrophin results in complex changes in dystrophic muscles. In order to compare the degree of secondary alterations in differently affected subtypes of skeletal muscles, we have conducted a global analysis of proteome-wide changes in various dystrophin-deficient muscles. In contrast to the highly degenerative mdx diaphragm muscle, which showed considerable alterations in 35 distinct proteins, the spectrum of mildly to moderately dystrophic skeletal muscles, including interosseus, flexor digitorum brevis, soleus, and extensor digitorum longus muscle, exhibited a smaller number of changed proteins. Compensatory mechanisms and/or cellular variances may be responsible for differing secondary changes in individual mdx muscles. Label-free mass spectrometry established altered expression levels for diaphragm proteins associated with contraction, energy metabolism, the cytoskeleton, the extracellular matrix and the cellular stress response. Comparative immunoblotting verified the differences in the degree of secondary changes in dystrophin-deficient muscles and showed that the up-regulation of molecular chaperones, the compensatory increase in proteins of the intermediate filaments, the fibrosis-related increase in collagen levels and the pathophysiological decrease in calcium binding proteins is more pronounced in mdx diaphragm as compared to the less severely affected mdx leg muscles. Annexin, lamin, and vimentin were identified as universal dystrophic markers.
Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®
Authors: Liu Jinwen , Zou Meijuan , Piao Hongyu , Liu Yi , Tang Bo , Gao Ying , Ma Ning , Cheng Gang
Published: June 2015

Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The aim of this study was to improve the physicochemical properties and bioavailability of a poorly water-soluble aprepitant by preparation of solid dispersions. The solid dispersions were characterized by dissolution, FTIR, XRPD, DSC, SEM and pharmacokinetic studies in rats. The dissolution rate of the aprepitant was significantly increased by solid dispersions, and XRD, DSC, and SEM analysis indicated that the aprepitant existed in an amorphous form within the solid dispersions. The result of dissolution study showed that the dissolution rate of SDs was nearly five-fold faster than aprepitant. FTIR spectrometry suggested the presence of intermolecular hydrogen bonds between the aprepitant and polymer. Pharmacokinetic studies in rats indicated that the degree drug absorption was comparable with that of Emend®. Aprepitant exists in an amorphous state in solid dispersions and the solid dispersions can markedly improve the dissolution and oral bioavailability of the aprepitant. The AUC0–t of the SDs was 2.4-fold that of the aprepitant. In addition, the method and its associated techniques are very easy to carry out.
Covalently Cross-Linked Arabinoxylans Films for Debaryomyces hansenii Entrapment
Authors: González-Estrada Ramsés , Calderón-Santoyo Montserrat , Carvajal-Millan Elizabeth , Valle Felipe , Ragazzo-Sánchez Juan , Brown-Bojorquez Francisco , Rascón-Chu Agustín
Published: June 2015

In the present study, wheat water extractable arabinoxylans (WEAX) were isolated and characterized, and their capability to form covalently cross-linked films in presence of Debaryomyces hansenii was evaluated. WEAX presented an arabinose to xylose ratio of 0.60, a ferulic acid and diferulic acid content of 2.1 and 0.04 µg∙mg−1 WEAX, respectively and a Fourier Transform Infra-Red (FT-IR) spectrum typical of WEAX. The intrinsic viscosity and viscosimetric molecular weight values for WEAX were 3.6 dL∙g−1 and 440 kDa, respectively. The gelation of WEAX (1% w/v) with and without D. hansenii (1 × 107 CFU∙cm−2) was rheologically investigated by small amplitude oscillatory shear. The entrapment of D. hansenii decreased gel elasticity from 1.4 to 0.3 Pa, probably by affecting the physical interactions between WEAX chains. Covalently cross-linked WEAX films containing D. hansenii were prepared by casting. Scanning electron microscopy images show that WEAX films containing D. hansenii were porous and consisted of granular-like and fibre microstructures. Average tensile strength, elongation at break and Young’s modulus values dropped when D. hansenii was present in the film. Covalently cross-lined WEAX containing D. hansenii could be a suitable as a functional entrapping film.
Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells
Authors: Xia Zhengxiang , Zhang Hong , Xu Danqing , Lao Yuanzhi , Fu Wenwei , Tan Hongsheng , Cao Peng , Yang Ling , Xu Hongxi
Published: June 2015

Two new xanthones, cowaxanthones G (1) and H (2), and 23 known analogues were isolated from an acetone extract of the leaves of Garcinia cowa. The isolated compounds were evaluated for cytotoxicity against three cancer cell lines and immortalized HL7702 normal liver cells, whereby compounds 1, 5, 8, and 15–17 exhibited significant cytotoxicity. Cell cycle analysis using flow cytometry showed that 5 induced cell cycle arrest at the S phase in a dose-dependent manner, 1 and 16 at the G2/M phase, and 17 at the G1 phase, while 16 and 17 induced apoptosis. Moreover, autophagy analysis by GFP-LC3 puncta formation and western blotting suggested that 17 induced autophagy. Taken together, our results suggest that these xanthones possess anticancer activities targeting cell cycle, apoptosis, and autophagy signaling pathways.
Mechanistic Effects of Calcitriol in Cancer Biology
Authors: Díaz Lorenza , Díaz-Muñoz Mauricio , García-Gaytán Ana , Méndez Isabel
Published: June 2015

Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways. In the context of cancer, calcitriol regulates the cell cycle, induces apoptosis, promotes cell differentiation and acts as anti-inflammatory factor within the tumor microenvironment. In this review, we address the different mechanisms of action involved in the antineoplastic effects of calcitriol.
Early Identification of Land Degradation Hotspots in Complex Bio-Geographic Regions
Authors: Lanfredi Maria , Coppola Rosa , Simoniello Tiziana , Coluzzi Rosa , D'Emilio Mariagrazia , Imbrenda Vito , Macchiato Maria
Published: June 2015

The development of low-cost and relatively simple tools to identify emerging land degradation across complex regions is fundamental to plan monitoring and intervention strategies. We propose a procedure that integrates multi-spectral satellite observations and air temperature data to detect areas where the current status of local vegetation and climate shows evident departures from the mean conditions of the investigated region. Our procedure was tested in Basilicata (Italy), which is a typical bio-geographic example of vulnerable Mediterranean landscape. We grouped Landsat TM/ETM+ NDVI and air temperature (T) data by vegetation cover type to estimate the statistical distributions of the departures of NDVI and T from the respective land cover class means. The pixels characterized by contextual left tail NDVI values and right tail T values that persisted in time (2002–2006) were classified as critical to land degradation. According to our results, most of the critical areas (88.6%) corresponded to forests affected by erosion and to riparian buffers that are shaped by fragmentation, as confirmed by aerial and in-situ surveys. Our procedure enables cost-effective screenings of complex areas able to identify raising hotspots that require urgent and deeper investigations.
Observing Land Subsidence and Revealing the Factors That Influence It Using a Multi-Sensor Approach in Yunlin County, Taiwan
Authors: Hsu Wei-Chen , Chang Hung-Cheng , Chang Kuan-Tsung , Lin En-Kai , Liu Jin-King , Liou Yuei-An
Published: June 2015

Land subsidence is a worldwide problem that is typically caused by human activities, primarily the removal of groundwater. In Western Taiwan, groundwater has been pumped for industrial, residential, agricultural, and aquacultural uses for over 40 years. In this study, a multisensor monitoring system comprising GPS stations, leveling surveys, monitoring wells, and Persistent Scatterer Interferometric Synthetic Aperture Radar (PS-InSAR) was employed to monitor land subsidence in Western Taiwan. The results indicate that land subsidence in Yunlin County was mainly affected by the compaction of subsurface soils and over-pumping of groundwater from deep soils. The study area comprised western foothills, characterized by sediments containing predominantly gravel, and coastal areas, where clay was predominant. The subsidence in coastal areas was more severe than that in the western foothills, as a result of groundwater removal. An additional factor affecting subsidence was the compaction of deep layers caused by deep groundwater removal and the deep-layer compaction was difficult to recover. Based on multisensor monitoring results, severe subsidence is mainly affected by compaction of subsurface soils, over-pumping of groundwater from deep soils, and deep soil compaction.
On-Board Event-Based State Estimation for Trajectory Approaching and Tracking of a Vehicle
Authors: Martínez-Rey Miguel , Espinosa Felipe , Gardel Alfredo , Santos Carlos
Published: June 2015

For the problem of pose estimation of an autonomous vehicle using networked external sensors, the processing capacity and battery consumption of these sensors, as well as the communication channel load should be optimized. Here, we report an event-based state estimator (EBSE) consisting of an unscented Kalman filter that uses a triggering mechanism based on the estimation error covariance matrix to request measurements from the external sensors. This EBSE generates the events of the estimator module on-board the vehicle and, thus, allows the sensors to remain in stand-by mode until an event is generated. The proposed algorithm requests a measurement every time the estimation distance root mean squared error (DRMS) value, obtained from the estimator’s covariance matrix, exceeds a threshold value. This triggering threshold can be adapted to the vehicle’s working conditions rendering the estimator even more efficient. An example of the use of the proposed EBSE is given, where the autonomous vehicle must approach and follow a reference trajectory. By making the threshold a function of the distance to the reference location, the estimator can halve the use of the sensors with a negligible deterioration in the performance of the approaching maneuver.
Loop Closing Detection in RGB-D SLAM Combining Appearance and Geometric Constraints
Authors: Zhang Heng , Liu Yanli , Tan Jindong
Published: June 2015

A kind of multi feature points matching algorithm fusing local geometric constraints is proposed for the purpose of quickly loop closing detection in RGB-D Simultaneous Localization and Mapping (SLAM). The visual feature is encoded with BRAND (binary robust appearance and normals descriptor), which efficiently combines appearance and geometric shape information from RGB-D images. Furthermore, the feature descriptors are stored using the Locality-Sensitive-Hashing (LSH) technique and hierarchical clustering trees are used to search for these binary features. Finally, the algorithm for matching of multi feature points using local geometric constraints is provided, which can effectively reject the possible false closure hypotheses. We demonstrate the efficiency of our algorithms by real-time RGB-D SLAM with loop closing detection in indoor image sequences taken with a handheld Kinect camera and comparative experiments using other algorithms in RTAB-Map dealing with a benchmark dataset.
An Inquiry into the Life Cycle of Systems of Inner Walls: Comparison of Masonry and Drywall
Authors: Condeixa Karina , Qualharini Eduardo , Boer Dieter , Haddad Assed
Published: June 2015

Life Cycle Assessment is a methodology that investigates impacts linked to a product or service during its entire life cycle. Life Cycle Assessment studies investigate processes and sub-processes in a fragmented way to ascertain their inputs, outputs and emissions and get an overview of the generating sources of their environmental loads. The lifecycle concept involves all direct and indirect processes of the studied object. This article aims to model the material flows in the masonry and drywall systems and internal walls in a Brazilian scenario, and calculate the climate change impacts generated by the transport of the component materials of the systems. Internal walls of a residential dwelling in Rio de Janeiro are analyzed from a qualitative inventory of all life cycles with an analysis of material flows, based on technical and academic literature. All Life Cycle Impact Assessment of the systems is carried out with international data from the database, and using the IPCC2013 method for climate change impacts. This study disregards the refurbishment and possible extensions within the use phase. Thus, the inventory identifies weaknesses of the systems while the impact assessment validates the results. This study allows us a complete understanding about the inner walls systems in the Brazilian scenario, evidencing its main weaknesses and subsidizes decision-making for the industry and for planning of the new buildings.
Optimum Fisheries Management under Climate Variability: Evidence from Artisanal Marine Fishing in Ghana
Authors: Akpalu Wisdom , Dasmani Isaac , Normanyo Ametefee
Published: June 2015

In most developing coastal countries, the artisanal fisheries sector is managed as a common pool resource. As a result, such fisheries are overcapitalized and overfished. In Ghana, in addition to anthropogenic factors, there is evidence of rising coastal temperature and its variance, which could impact the environmental carrying capacity of the fish stock. This study investigates the effect of climate variation on biophysical parameters and yields. Our results indicate that the rising temperature is decreasing the carrying capacity. As a result, an optimum tax on harvest must reflect climate variability, as well as the congestion externality.
Neurotoxic Effects of Platinum Compounds: Studies in vivo on Intracellular Calcium Homeostasis in the Immature Central Nervous System
Authors: Bernocchi Graziella , Fanizzi Francesco , De Pascali Sandra , Piccolini Valeria , Gasperini Caterina , Insolia Violetta , Bottone Maria
Published: June 2015

Platinum compounds cause significant clinical neurotoxicity. Several studies highlight neurological complications especially in paediatric oncology patients with Central Nervous System (CNS) and non-CNS malignancies. To understand the toxicity mechanisms of platinum drugs at cellular and molecular levels in the immature brain, which appears more vulnerable to injury than in the adult one, we compared the effects in vivo of the most used platinum compounds, i.e., cisdichlorodiammineplatinum (cisplatin, cisPt), and the new [Pt(O,O′-acac)(γ-acac)(DMS)] (PtAcacDMS). As models of developing brain areas, we have chosen the cerebellum and hippocampus dentate gyrus. Both areas show the neurogenesis events, from proliferation to differentiation and synaptogenesis, and therefore allow comparing the action of platinum compounds with DNA and non-DNA targets. Here, we focused on the changes in the intracellular calcium homeostasis within CNS architecture, using two immunohistochemical markers, the calcium buffer protein Calbindin and Plasma Membrane Calcium ATPase. From the comparison of the cisPt and PtAcacDMS effects, it emerges how essential the equilibrium and synergy between CB and PMCA1 is or how important the presence of at least one of them is to warrant the morphology and function of nervous tissue and limit neuroarchitecture damages, depending on the peculiar and intrinsic properties of the developing CNS areas.
Characterization of Equine Infectious Anemia Virus Integration in the Horse Genome
Authors: Liu Qiang , Wang Xue-Feng , Ma Jian , He Xi-Jun , Wang Xiao-Jun , Zhou Jian-Hua
Published: June 2015

Human immunodeficiency virus (HIV)-1 has a unique integration profile in the human genome relative to murine and avian retroviruses. Equine infectious anemia virus (EIAV) is another well-studied lentivirus that can also be used as a promising retro-transfection vector, but its integration into its native host has not been characterized. In this study, we mapped 477 integration sites of the EIAV strain EIAVFDDV13 in fetal equine dermal (FED) cells during in vitro infection. Published integration sites of EIAV and HIV-1 in the human genome were also analyzed as references. Our results demonstrated that EIAVFDDV13 tended to integrate into genes and AT-rich regions, and it avoided integrating into transcription start sites (TSS), which is consistent with EIAV and HIV-1 integration in the human genome. Notably, the integration of EIAVFDDV13 favored long interspersed elements (LINEs) and DNA transposons in the horse genome, whereas the integration of HIV-1 favored short interspersed elements (SINEs) in the human genome. The chromosomal environment near LINEs or DNA transposons potentially influences viral transcription and may be related to the unique EIAV latency states in equids. The data on EIAV integration in its natural host will facilitate studies on lentiviral infection and lentivirus-based therapeutic vectors.
Investigating Willingness to Pay to Improve Water Supply Services: Application of Contingent Valuation Method
Authors: Tussupova Kamshat , Berndtsson Ronny , Bramryd Torleif , Beisenova Raikhan
Published: June 2015

Safe water supply is one of the important Millennium Goals. For development of market water supply services, the willingness of consumers to pay is essential. The consumers’ willingness to pay (WTP) for piped water supply using the contingent valuation (CV) method with different starting point bids was investigated for the Pavlodar Region, Kazakhstan. The results showed that households with access to groundwater (well or borehole water users) perceived this as of good quality. Consumers without access to groundwater used open-source, standpipe or delivered water for which they had to travel and spend time or to pay. Open source water and standpipe water quality was perceived as bad or satisfactory. More than 90% of the consumers were willing to pay for better water quality and regular water supply. The mean WTP was estimated to be about 1120 in bids and about 1590 KZT per household per month in open-ended question format (150 KZT is ~1 USD as of January 2012). The results can be used to better identify the proper technological choice and the level of service to be provided making rural water projects both sustainable and replicable at a larger scale.
Effects of Land Use and Climate Change on Groundwater and Ecosystems at the Middle Reaches of the Tarim River Using the MIKE SHE Integrated Hydrological Model
Authors: Keilholz Patrick , Disse Markus , Halik Ümüt
Published: June 2015

The Tarim basin is a unique ecosystem. The water from the Tarim River supports both wildlife and humans. To analyze the effects of both land use and climate changes on groundwater, a research site was established at Yingibazar, which is a river oasis along the middle section of the Tarim River. A hydrological survey was performed to assess the general water cycle in this area with special emphasis on groundwater replenishment as well as the impact of agricultural irrigation on the riparian natural vegetation with respect to salt transport and depth of groundwater. Although high-resolution input data is scarce for this region, simulation of water cycle processes was performed using the hydrological model MIKE SHE (DHI). The results of the calibrated model show that natural flooding is the major contributor to groundwater recharge. There is also a close interaction between irrigated agricultural areas and the adjacent natural vegetation for groundwater levels and salinity up to 300 m away from the fields. Furthermore, the source of water used for irrigation (i.e., river and/or groundwater) has a high impact on groundwater levels and salt transportation efficiency. The ongoing expansion of agricultural areas is rapidly destroying natural vegetation, floodplains, and their natural flow paths. Our results show that more unstable annual Tarim floods will occur in the future under the background of climate change. Therefore, integrated hydrological simulations were also performed for 2050 and 2100 using MIKE SHE. The results confirm that after the glaciers melt in the Tian Shan Mountains, serious aquifer depletion and environmental degradation will occur in the area, causing great difficulties for the local people.
Spatial Downscaling of TRMM Precipitation Product Using a Combined Multifractal and Regression Approach: Demonstration for South China
Authors: Xu Guanghua , Xu Xianli , Liu Meixian , Sun Alexander , Wang Kelin
Published: June 2015

The lack of high spatial resolution precipitation data, which are crucial for the modeling and managing of hydrological systems, has triggered many attempts at spatial downscaling. The essence of downscaling lies in extracting extra information from a dataset through some scale-invariant characteristics related to the process of interest. While most studies utilize only one source of information, here we propose an approach that integrates two independent information sources, which are characterized by self-similar and relationship with other geo-referenced factors, respectively. This approach is applied to 16 years (1998–2013) of TRMM 3B43 monthly precipitation data in an orographic and monsoon influenced region in South China. Elevation, latitude, and longitude are used as predictive variables in the regression model, while self-similarity is characterized by multifractals and modeled by a log-normal multiplicative random cascade. The original 0.25° precipitation field was downscaled to the 0.01° scale. The result was validated with rain gauge data. Good consistency was achieved on coefficient of determination, bias, and root mean square error. This study contributes to the current precipitation downscaling methodology and is helpful for hydrology and water resources management, especially in areas with insufficient ground gauges.
Controls on Suspended Sediment Concentrations and Turbidity within a Reforested, Southern Appalachian Headwater Basin
Authors: Miller Jerry , Sinclair Jacob , Walsh Danvey
Published: June 2015

Water quality data collected between 2007 and 2014 within the Allen Creek Watershed were used to: (1) determine the factors controlling the temporal variations in turbidity and suspended sediment concentration (SSC) within a representative, high-gradient headwater basin in the Southern Appalachians; and (2) assess the recovery of water quality following extensive logging operations during the early to mid-1900s. Regression analysis suggests that suspended sediment is primarily derived from upland areas and variations in concentration reflect rainfall intensity and total event precipitation. Overall, SSC and turbidity were low in stream waters in comparison to both reference values for stable streams and more developed basins in the region. Some floods were characterized by high SSC values, but limited turbidity and vice versa. Differences in measured SSC and turbidity between storms reflect different controls on the two parameters, and the apparent influence of natural organic matter on turbidity during rainfall events that are incapable of transporting sediment to the channel via overland flow. Low SSC and turbidity values are presumably related to the reforestation of hillslopes and riparian buffers following the cessation of logging operations. They also are due to a historical reduction in the sedimentological connectivity of hillslopes and tributaries with the axial channel that occurred during logging operations.
Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis
Authors: An Taixue , Qin Sihua , Xu Yong , Tang Yueting , Huang Yiyao , Situ Bo , Inal Jameel M. , Zheng Lei
Published: June 2015

Exosomes, membrane vesicles of 40–100 nm in diameter, are derived from endosomes in various cells. The bioactive molecules specifically packed into exosomes can be horizontally transferred into recipient cells changing their biological properties, by which tumour cells continuously modify their surrounding microenvironment and distant target cells favouring cancer metastasis. It has been suspected for a long time that exosomes participate in the whole process of tumour metastasis. Although there is much unknown and many controversies in the role of cancer exosome, the major contribution of tumour‐associated exosomes to different steps of cancer metastasis are demonstrated in this review. Mainly because these exosomes are easily accessible and capable of representing their parental cells, exosomes draw much attention as a promising biomarker for tumour screening, diagnosis and prognosis. Currently, researchers have found numerous biomarkers in exosomes with great potential to be utilized in personalized medicine. In this article, we summarize the roles of biomarkers, which are validated by clinical samples. Even though many conundrums remain, such as exosome extraction, large multicentre validation of biomarkers and data interpretation, exosomes are certain to be used in clinical practice in the near future as the field rapidly expands.
Alternative types of molecule-decorated atomic chains in Au–CO–Au single-molecule junctions
Authors: Balogh Zoltán , Makk Péter , Halbritter András
Published: June 2015

We investigate the formation and evolution of Au–CO single-molecule break junctions. The conductance histogram exhibits two distinct molecular configurations, which are further investigated by a combined statistical analysis. According to conditional histogram and correlation analysis these molecular configurations show strong anticorrelations with each other and with pure Au monoatomic junctions and atomic chains. We identify molecular precursor configurations with somewhat higher conductance, which are formed prior to single-molecule junctions. According to detailed length analysis two distinct types of molecule-affected chain-formation processes are observed, and we compare these results to former theoretical calculations considering bridge- and atop-type molecular configurations where the latter has reduced conductance due to destructive Fano interference.
Donor–acceptor type co-crystals of arylthio-substituted tetrathiafulvalenes and fullerenes
Authors: Lu Xiaofeng , Sun Jibin , Zhang Shangxi , Ma Longfei , Liu Lei , Qi Hui , Shao Yongliang , Shao Xiangfeng
Published: June 2015

A series of donor–acceptor type co-crystals of fullerene (as the acceptor) and arylthio-substituted tetrathiafulvalene derivatives (Ar-S-TTF, as the donor) were prepared and their structural features were thoroughly investigated. The formation of co-crystals relies on the flexibility of Ar-S-TTF and the size matches between Ar-S-TTF and fullerene. Regarding their compositions, the studied co-crystals can be divided into two types, where types I and II have donor:acceptor ratios of 1:1 and 1:2, respectively. Multiple intermolecular interactions are observed between the donor and acceptor, which act to stabilize the structures of the resulting co-crystals. In the type I co-crystals, the fullerene molecule is surrounded by four Ar-S-TTF molecules, that is, two Ar-S-TTF molecules form a sandwich structure with one fullerene molecule and the other two Ar-S-TTF molecules interact with the fullerene molecule along their lateral axes. In the type II co-crystals, one fullerene molecule has the donor–acceptor mode similar to that in type I, whereas the other fullerene molecule is substantially surrounded by the aryl groups on Ar-S-TTF molecules and the solvent molecules.
CRITICAL INFRASTRUCTURE RISK IN NHS ENGLAND: PREDICTING THE IMPACT OF BUILDING PORTFOLIO AGE
Authors: MILLS Grant R. W. , DEKA Lipika , PRICE Andrew D. F. , RICH-MAHADKAR Sameedha , PANTZARTZIS Efthimia , SELLARS Peter
Published: June 2015

NHS Trusts in England must adopt appropriate levels of continued investment in routine and backlog maintenance if they are to ensure critical backlog does not accumulate. This paper presents the current state of critical backlog maintenance within the National Health Service (NHS) in England through the statistical analyses of 115 Acute NHS Trusts. It aims to find empirical support for a causal relationship between building portfolio age and year-on-year increases in critical backlog. It makes recommendations for the use of building portfolio age in strategic asset management. The current trend across this sample of NHS Trusts may be typical of the whole NHS built asset portfolio and suggests that most Trusts need to invest between 0.5 and 1.5 per cent of income (depending upon current critical backlog levels and Trust age profile) to simply maintain critical backlog levels. More robust analytics for building age, condition and risk-adjusted backlog maintenance are required.
RAPPORT AND ITS MANAGERIAL IMPLICATIONS IN FM SERVICE OUTSOURCING RELATIONSHIPS
Authors: HOU Huiying , HO Daniel Chi Wing
Published: June 2015

In Hong Kong, client companies tend not to renew contracts with relationship partners and may change facilities management (FM) service providers on a frequent basis. This phenomenon is common in the FM industry. Inspired by the phenomenon of changing service providers, this study sheds light on a social relations perspective in outsourcing relationships and aims to investigate the factors that affect FM service outsourcing relationships. Open interviews with 20 FM managers were conducted, and the interview results were analysed with content analysis and coding methods. The empirical findings were interpreted on two levels. First, FM managers believe that rapport is an influential factor that affects FM service outsourcing relationships. Second, the courses in which the interviewees explain the manifestation of rapport and its significance reveal that common goals, shared values, trust, openness, and coordination are the factors that not only nurture the formation of rapport, but also have significant influences on social relations in the process of outsourcing. A framework has been developed to describe the conceptual relationships found in the empirical findings from the interviews. Eight guidelines have been outlined to indicate the managerial implications of this study.
New records of Ichneumonidae (Hymenoptera) for the Italian fauna
Authors: Di Giovanni Filippo , Reshchikov Alexey , Riedel Matthias , Diller Erich , Schwarz Martin
Published: June 2015

New distributional records on 55 ichneumonids (Hymenoptera, Ichneumonidae) from Italy are provided. Of these, 47 species are new for Italy, including representatives of the subfamily Diacritinae and of the tribes Zimmeriini (Ichneumoninae) and Pseudorhyssini (Poemeniinae); six species are new for Sardinia, one for Sicily and one for the Italian mainland. The hitherto unknown female of Baranisobas hibericus Heinrich, 1972 (Ichneumoninae) is described.