bluuebunny/crossref_metadata_2025 huggingface dataset:
Anopheles species associated with malaria transmission in gold-mining areas of northwest Colombia
Authors: Rojas Marco Andres , Velasco María Camila , Ahumada Martha , Chaparro Pablo , Yasnot Maria Fernanda , Orjuela Lorena Isabel
Published: October 2023

Background
In Colombia, mining is one of the main economic activities in four ecoepidemiological areas that contribute approximately 80% of malaria cases per year. Mining activity generates changes in the environment and opens new available breeding sites to be colonized by malaria vector mosquitoes in the area, increasing the malaria transmission risk.
Objective
To identify the presence of Anopheles species and their role in malaria transmission in five malaria-endemic localities with gold mining extraction in El Bagre, Antioquia, Colombia.
Methods
A cross-sectional study was conducted in five localities of El Bagre, Antioquia. Adult mosquitoes were collected indoors and outdoors. The taxonomic status of Anopheles species was confirmed by COI sequencing. All mosquitoes were tested by ELISA to establish infection with Plasmodium spp., and infections were confirmed using nested PCR. Immature mosquitoes were captured from the larval habitats. The association between the presence of Anopheles species and the physical parameters of larval habitat was estimated through multiple correspondence analysis and principal component analysis.
Findings:
Eleven Anopheles species were identified. Six specimens were positive for PCR Plasmodium test: An. darling infected with P. falciparum, An. nuneztovari s.s., and An. punctimacula infected with P. vivax. A total of 106 larval habitats were characterized. Using a multiple correspondence analysis, it was possible to associate the presence of An. triannulatus s.l., An. nuneztovari s.s., An. rangeli, An. oswaldoi B., An. albitarsis I, An. strodei, An. pseudopunctipennis and An. darlingi with larval habitats generated by mining activity.
Main conclusions:
An. darlingi, An. nuneztovari s.s. and An. punctimacula showed anthropophilic behavior. These species were detected infected with P. falciparum and P. vivax vk 210, confirming their role in malaria transmission in mining areas. The presence of immature stages of these species in gold mining excavations confirms these habitats as potential breeding sites for malaria vectors in El Bagre.
Development and Validation of a Protective Behavioral Strategies Scale for Individuals who use Opioids: Preliminary Findings and Future Directions
Authors: Luba Rachel , Gopaldas Manesh , Martinez Suky , Comer Sandra D.
Published: October 2023

Background: Protective Behavioral Strategies (PBS) are individually implemented harm reduction (HR) strategies to reduce the frequency or severity of risks associated with drug use. Existing scales measuring PBS for alcohol and cannabis suggest PBS are associated with reductions in associated problems. Despite many HR strategies related to opioid use, no PBS scale has been developed in the context of opioid use. To address this gap, this study aimed to test and validate a PBS scale for individuals using opioids (PBSO).
Methods: An online survey utilized a 32-item PBS scale for individuals endorsing recent opioid use, and measured opioid use frequency, HR service use, and experience of opioid overdose. PBSO items were rated on a Likert scale ranging from “never” (0) to “always” (6), and an exploratory factor analysis (EFA) examined factor structure.
Results: In the current sample (n=499; 32% female), EFA suggested a 3-factor structure among the 28 items retained, accounting for 51% of total variance. Factor 1 reflected health-service seeking, Factor 2 reflected individually-implemented and dose-reduction strategies, Factor 3 reflected social strategies, and Factor 4 reflected strategies related to injection drug use. Endorsement of PBSO items were slightly above “occasional” (3). PBSO use appeared positively related to past-month HR service utilization and negatively related to opioid use frequency.
Conclusions: Findings provide preliminary support for the PBSO scale as a valid and reliable measure. Further work is needed to test this scale in larger samples, and future work should explore the association between PBSO and relevant health outcomes, and whether factor scores differentially impact these outcomes.
Three-dimensional shear wave velocity models for the Atlantic upper mantle
Authors: James Esther K. , Komaravalli Davina S.
Published: October 2023

We investigate the three-dimensional shear-velocity structure of the upper mantle beneath the Atlantic Ocean using two approaches. One, we invert travel time measurements that were first presented in James et al., (2014) for approximately 10,000 fundamental-mode Rayleigh waves traversing the Atlantic basin, in the period range 30–125 seconds, to derive a layered 3-D model. Two, we explore continuous depth-dependent variations in vertically-polarized shear velocity, VSV, with a splined model by inverting phase velocities from the 2-D maps in James et al. (2014). For the layered model, we assume that VSV is constant in a given layer, which allows us to capture and compare the velocity structure in shallow and deep layers. Varying the boundary depth between the shallow and deep layers shows that age dependence is strongly observed in the shallow layers but has a very weak or no signal in the deep layers. This is the case even when the layer-separation boundary depth is as shallow as 100 km. For the splined models, we allow VSV to vary continuously with depth to observe gradual VSV changes with depth. Shear-velocity depth-profile comparisons reveal a significant reduction in age-dependence around 200-km depth. The splined-model approach also allows us to make quantitative shear velocity comparisons across several seafloor age regions and with results from previous studies of the Pacific basin (e.g., Nishimura and Forsyth 1989; Gaherty et al. 1996). We find that in some cases, shear velocities are higher in the Atlantic basin when compared to shear velocities in the Pacific basin for the same seafloor ages.
Gd-EOB-DTPA enhanced MRI is superior in selecting surgical candidates for patients with early-stage hepatocellular carcinoma: An analysis in terms of oncological outcomes
Authors: Ye Zhiwei , Zhao Jing , Hu Dandan , Yang Zhoutian , Chen Jinbin , Xu Li , Zhou Zhongguo , Chen Minshan , Zhang Yaojun
Published: October 2023

Purpose
To determine the value of preoperative Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging (MRI) vs the controls (extracellular contrast agent MRI and CT) in selecting surgical candidates for patients with hepatocellular carcinoma in terms of oncological outcomes after hepatectomy.
Methods
This retrospective study included 542 consecutive patients who underwent radical hepatectomy for HCC. One group underwent preoperative Gd-EOB-DTPA-Enhanced MRI and the other group underwent contrast enhanced CT or extracellular contrast agents MRI. We compared oncologic outcomes including recurrence free survival and overall survival between the three groups. Subgroup analyses were also performed to provide more specific candidates or beneficiaries for preoperative EOB-MRI.
Results
Totally 244 patients had tumor recurrence, with 55 in the EOB-MRI Group and 106 in the Routine-MRI Group and 83 in the CT Group (P = 0.010), as for early recurrence (< 2 years), 40 (27.03%) ,78(35.78%) and 62(35.22%) patients in each group (P = 0.018). The 1, 2, 3 years RFS were 82.4%, 73.0%, and 68.2% in EOB-MRI Group, 70.2%, 64.3%, and 56.9% in Routine-MRI Group, 76.8%, 64.83%, and 58.9% in CT Group(P = 0.010). The 1, 2, 3 years OS were 89.19%, 83.11%, and 80.41% in EOB-MRI Group, 79.82%, 73.86%, and 67.44% in Routine-MRI Group, and 86.55%, 76.14%, and 69.32% in CT Group (P = 0.016). Subgroup analysis showed that significant difference in RFS was observed in patients with solitary tumor < 3cm.
Conclusions
Preoperative EOB-MRI is superior to contrast-enhanced CT or extracellular contrast agents MRI in selecting surgical candidates at low risk of recurrence following hepatic resection for HCC.
Trust Development in Online Competitive Game Environments: A Network Analysis Approach
Authors: Fehlhaber Anna Lena , EL-Awad Usama
Published: October 2023

Trust seems to become established even in scenarios where the prerequisites for trust are complicated by conditions that evoke scepticism. Nonetheless, trust emerges, a phenomenon that is to be comprehended and examined in the present experimental inquiry. In order to comprehensively capture the process, a competitive online game environment was used to document the development of trust networks, directionality, and strength using network analysis. Despite the conditions conducive to distrust in this game setting, acts of trust were exhibited. Robust trust bonds persisting over the course of gameplay appear to manifest mostly dyadic or triadic, with participant embeddedness within the network and homophily in terms of general trustfulness towards strangers being conducive factors for trust bonding and game survivability. This study hence contributes to the overall understanding of online trust development and offers several further research opportunities in a mostly unexplored field.
Qualifying and Modeling Three Dimensions of Knowledge “mise en scène” in a College Space Tweeting Environment
Authors: Robert Abiodun Charles
Published: October 2023

The work evaluated evolving economy as heavily characterized by the knowledge of the untapped college students and their activities that is external to four walls of classical learning. Such knowledge was deemed social knowledge that is qualifiable and exchangeable. Characteristically, such social knowledge was seen from three factors of personalization, environment, and social interactions. It was given a digital dimension that can be expressed as JSON object. Scenario of usage was attempted at the end of the discussion. The overall objective was to prepare the ground for evaluating knowledge of college students outside the conventional factors presently in use. This was conceived particularly possible when applied to technology of social media.
The demographic, laboratory and genetic factors associated with Long Covid-19 Syndrome: a case-control study
Authors: Torki Ensiye , Hoseininasab Fahimeh , Moradi Marjan , Sami Ramin , Sullman Mark J. M. , Fouladseresht Hamed
Published: October 2023

Objective
Long Covid-19 syndrome (LCS) manifests with a wide range of clinical symptoms, yet the factors associated with LCS remain poorly understood. The current study aimed to investigate the relationships that demographic characteristics, clinical history, laboratory indicators, and the frequency of HLA-I alleles have with the likelihood of developing LCS.
Methods
We extracted the demographic characteristics and clinical histories from the medical records of 88 LCS cases (LCS+ group) and 96 age/sex-matched individuals without LCS (LCS− group). Furthermore, we evaluated the clinical symptoms, serum levels of interleukin (IL)-6 and tumor necrosis factor-α, laboratory parameters, and the frequencies of HLA-I alleles. Following this we used multiple logistic regression to investigate the association these variables had with LCS.
Results
Subjects in the LCS+ group were more likely to have experienced severe Covid-19 symptoms and had higher body mass index (BMI), white blood cell, lymphocyte counts, C-reactive protein (CRP), and IL-6 levels than those in the LCS− group (for all: P˂0.05). Moreover, the frequencies of the HLA-A*11, -B*14, -B*38, -B*50, and -C*07 alleles were higher in the LCS+ group (for all: P˂0.05). After adjusting for the most important variables, the likelihood of suffering from LCS was significantly associated with BMI, CRP, IL-6, the HLA-A*11, and -C*07 alleles, as well as a positive history of severe Covid-19 (for all: P˂0.05).
Conclusion
Our study showed that a history of severe Covid-19 during the acute phase of the disease, the HLA-A*11, and -C*07 alleles, higher BMI, as well as elevated serum CRP and IL-6 levels, were all associated with an increased likelihood of LCS.
Microneedles loaded with cerium-manganese oxide nanoparticles for targeting macrophages in the treatment of rheumatoid arthritis
Authors: Xia Tian , Zhu Yuting , Li Kaiqiang , Hao Ke , Chai Yingqian , Jiang Hongyi , Lou Chao , Yu Jiachen , Yang Wei , Wang Jilong , Deng Junjie , Wang Zhen
Published: October 2023

Background
Rheumatoid arthritis (RA) is a prevalent inflammatory autoimmune disease characterised by persistent inflammation and joint damage with elevated levels of reactive oxygen species (ROS). Current treatment modalities for RA have significant limitations, including poor bioavailability, severe side effects, and inadequate targeting of inflamed joints. Herein, we synthesised cerium/manganese oxide nanoparticles (NPs) as efficient drug carriers with antioxidant and catalytic-like functions that can eliminate ROS to facilitate the polarization of macrophages phenotype from M1 to M2 and alleviate inflammation. Methotrexate (MTX), a first-line RA medication, was loaded into the NPs, which were further modified with bovine serum albumin (BSA) and integrated into dissolving hyaluronic acid-based microneedles (MNs) for transdermal delivery.
Result
This innovative approach significantly enhanced drug delivery efficiency, reduced RA inflammation, and successfully modulated macrophage polarization toward an anti-inflammatory phenotype.
Conclusion
This research not only presents a promising drug delivery strategy for RA but also contributes broadly to the field of immune disease treatment by offering an advanced approach for macrophage phenotypic reprogramming.
TAWC: Text Augmentation with Word Contributions for Imbalance Aspect-based Sentiment Classification
Authors: Santoso Noviyanti , Mendonça Israel , Aritsugi Masayoshi
Published: October 2023

Text augmentation plays an important role in enhancing the generalization performance of language models. However, traditional methods often overlook the unique roles that individual words play in conveying meaning in text and imbalance class distribution, thereby risking suboptimal performance and compromising the model's generalization ability. This limitation motivated us to create a novel technique, Text Augmentation with Word Contributions (TAWC). Our approach tackles this problem in two core steps: Firstly, it employs analytical correlation and semantic similarity metrics to discern the relationships between words and their associated aspect polarities; and secondly, it tailors distinct augmentation strategies to individual words, based on their identified functional contributions within the text. Extensive experiments on two aspect-based sentiment analysis datasets reveal that TAWC significantly improves the classification performance of popular language models, achieving gains of up to 4%, thereby setting a new standard in the field of text augmentation.
Expression and function assessment of a novel fibrinogen immuno-lectin from Hyalomma rufipes (Acari: Ixodidae)
Authors: Gao Zhihua , Zhao Yinan , Xu Xiaofeng , Zhang Songbo , Dong Kexin , Wang Yikui , Lv Wenxia , Yang Xiaolong
Published: October 2023

Lectin is a sugar-binding protein crucial for the innate immunity of ticks and acts as an important antibacterial peptide. When ticks are damaged externally, lectin can initiate a rapid defence mechanism. In this research, a novel immune lectin gene, Hr-lectin, was identified from Hyalomma rufipes. The gene has a size of 852 bp and a molecular weight of 31.509 KDa, encoding 283 amino acids. It is a C-type lectin with a signal peptide and has a theoretical isoelectric point of 6.23. The lectin gene Hr-lectin was analyzed by qPCR. The findings indicate that the expression of lectin was significantly greater in eggs compared to other stages. Similarly, the expression in the ovary was higher than that in other tissues, which was significantly different from other tissues. Additionally, rHr-lectin exhibited a degree of inhibition on Gram-positive bacteria, Gram-negative bacteria, and fungi. During the erythrocyte agglutination experiment, it was observed that rHr-lectin displayed varying agglutination effects on red blood cells. The outcomes of RNAi targeting Hr-lectin exhibited a significant rise in tick mortality rates and a decrease in the average weights of engorged adults and eggs. Regarding morphological characteristics, ticks displayed diminished body size and gray coloration following RNA interference. However, this treatment did not exert any significant influence on the form of the tick eggs.
Estimation of radiation heat loss from hydrogen-air jet diffusion flame
Authors: Parvatikar Shreesh , Kumar Pradeep
Published: October 2023

In the present work, the numerical study is performed to estimate the contribution of radiation in H2-air jet diffusion combustion by a non-gray radiation property model, i.e., full spectrum k-distribution method and a comparative study is performed with a very simplistic model of radiation property i.e.Plank mean method.
For the accurate radiation property modelling, the HITEMP-2010 database has been used to calculate the spectral absorption coefficients of H2O vapor for different thermodynamic states. Further, the random variation of spectral absorption coefficients has been reordered in smooth monotonically increasing function using the full spectrum k-distribution method (FSK). A look-up table is developed for different mole fractions and temperatures of H2O vapor. The calculation of absorption coefficients at thermodynamic states other than the look-up table has been performed using the four dimension interpolation technique. The results reveal that the FSK method further more reduces 90-100 K peak temperature compared to Planck mean method and show better agreement with the experimental results. There is significant loss of energy in the combustion flame by radiation mode of heat transfer. This reduction of energy (reduction in temperature) is distributed on the computational boundaries by mostly radiation mode of heat transfer. The maximum heat flux on the cylindrical and circular surface by the FSK method is found to be 2000 and 900 W/m2, respectively.
Prevalence of Low Birth Weight and Associated Factors among Neonates in Public Hospitals of Addis Ababa, Ethiopia in 2022.
Authors: Getaneh Chala , lambebo Abera , Mezemir Yordanos
Published: October 2023

Background:-The great majority of low-birth-weight births occur in low- and middle-income countries. Especially in the most vulnerable populations in sub-Saharan Africa including Ethiopia.
Objective:- study was aimed to assess low birth weight and factorsassociated with low birth weight among neonates in public hospitalsin Adiss Abeba.
Method:- Institution-based cross-sectional study design was conducted to assess the prevalence and associated factors of low birth weight among newborn babies in public hospitals in Addis Ababa, Ethiopia. The data was collected using an interviewer-administered structured questionnaire. The collected data was cleared and entered into EPI info version 7and .0 and then exported to spss version 20. bi variate and multivariate logistic regression analyses were employed to identify associated factors with low birth weight. After bivariate regression analysis, variables with a P value less than 0.2 were included in multivariable logistic regression. An unadjustedd ratio with 95% CI was calculated to see the association of vvavariablesth low birth weight at the sinsignificant value of P<0.05.
RESULT:-the study was conducted among 369 mothers who had a new born baby.And in this study, the prevalence of low birth weight was 15.2% at 95%CI=(11.7-18.7).And residing in rural area AOR=2.50(95%CI=(1.078-5.148),Birth interval <24 month AOR=2.531 95%CI=( 1.422-.4.507),Pregnancy complication AOR=13.53095 % CI =(6.080-30.105),ANC follow up (AOR = 5.14(95 % CI=(1.260-21.017)).gestational age AOR 7.446(95%+CI=(3.104-17.862),sex of the new born AOR=3.24(95%CI=(1.354-7.7561) were significantly associated factors.
CONCLUSION:- The prevalence of low birth weight in this study was 15.2%, and it is lower than the national prevalence, And residential are, Birth interval, pregnancy complications, ANC followup,gestational age and sex of neonates were significantly associated with low birth weight.
Identification of Risk Factors of Tumor Recurrence and Model Establishing for Patients with Intermediate and Higher Risk NMIBC Followed by Intravesical BCG Instillation After TmLRBT or TURBT
Authors: Sun Jian-Xuan , Zeng Na , Liu Chen-Qian , Xu Jin-Zhou , An Ye , Xu Meng-Yao , Zhang Si-Han , Zhong Xing-Yu , Ma Si-Yang , He Hao-Dong , Liu Zheng , Xia Qi Dong , Wang Shao-Gang
Published: October 2023

Purpose
The disease recurrence and progression bring great burden to patients with intermediate and higher risk non-muscle invasive bladder cancer (NMIBC). Intravesical bacille Calmette-Guérin (BCG) instillation is recommended as a preventive treatment of disease recurrence and progression for NMIBC patients after conventional transurethral resection of bladder tumors (TURBT) or thulium laser resection of bladder tumors (TmLRBT). In this study, we constructed a novel nomogram to predict postoperative tumor recurrence and progression for BCG-treated patients with intermediate and higher risk NMIBC after TURBT or TmLRBT.
Methods
Patients with intermediate, high and very high risk NMIBC that undergone TURBT or TmLRBT followed by BCG instillation were retrospectively collected from August, 2018 to December, 2019. Independent prognostic factors were determined by univariate logistic regression, multivariable logistic regression, the least absolute shrinkage and selection operator (LASSO) regression and multivariable cox regression. A nomogram was established to calculate the recurrence and progression probability of targeted patients. The predictive efficacy of this nomogram model was also evaluated.
Results
76 patients were included, among which 22 experienced tumor recurrence. The multivariable cox regression showed that previous bladder tumor history (HR = 4.07, 95% CI: 1.56 ~ 10.60, P = 0.004) and number of BCG immunotherapy (HR = 0.87, 95%CI: 0.82 ~ 0.93, P < 0.001) were two independent prognostic factors of bladder tumor recurrence. A nomogram model was established and proofed to have good predictive capacity.
Conclusion
Patients without previous bladder tumor history and having more intravesical BCG instillations are likely to have better RFS. The nomogram and the risk index which were constructed to predict the RFS and PFS of patients may help urologists choose appropriate disease management for patients.
A Study on Teachers' Perception and Implementation of English Class Using EduTech: Focused on the Focus Group Interview.
Authors:   British And American Language And Literature Association Of Korea, Lee Heejung
Published: October 2023

The purpose of this study is to find out teachers' perceptions and implementation of English class using edutech. An Online survey and a focus group interview were conducted. The results of the study are as follows. First, teachers mentioned that the purpose of using edutech is to improve students' activity and induce interest. Second, regarding the experience of using edutech, they used Classcard and Chatterfix the most, and stated that students' speaking ability and concentration have improved. Third, as a result of examining teachers' perceptions of edutech, the most common response was that more classes using edutech should be increased for future education. Fourth, they responded that the advantage of English class using edutech was to induce interest and achievement. On the other hand, they pointed to environmental restrictions and difficulties of use as disadvantages. Based on these research results, this paper presents several suggestions.
Remarks on the Solution of Fractional Ordinary Differential Equations Using Laplace Transform Method
Authors: Mamman John Ojima , Oguche Gloria Ojima-Ojo , Akwu Usman
Published: October 2023

In this work we used the Laplace transform method to solve linear fractional-order differential equation, fractional ordinary differential equations with constant and variable coefficients. The solutions were expressed in terms of Mittag-Leffler functions, and then written in a compact simplified form. As a special case for simplicity, the order of the derivative determined the order of the solution that was obtained. This paper presented several case studies involving the implementation of Fractional Order calculus-based models, whose results demonstrate the importance of Fractional Order Calculus.
DISTRIBUTION OF ELECTRICAL CURRENT DENSITY INTO PLANAR MAGNETIC COMPONENTS ACCORDING TO FREQUENCY
Authors:   Departement of Electrical Engeneering, National Institut of Sciences and Technologies of Abeche, Chad., Boukhari M.I. ,   Hubert Curien Laboratory (LabHC), Jean Monnet University of Saint-Etienne, France., Oumar D.A ,   Departement of Electrical Engeneering, National Institut of Sciences and Technologies of Abeche, Chad.,   Hubert Curien Laboratory (LabHC), Jean Monnet University of Saint-Etienne, France., A.A Mahamat ,   Departement of Electrical Engeneering, National Institut of Sciences and Technologies of Abeche, Chad., Bechir M.H. ,   Departement of Electrical Engeneering, National Institut of Sciences and Technologies of Abeche, Chad., Dari Y.D ,   Departement of Electrical Engeneering, National Institut of Sciences and Technologies of Abeche, Chad.,   Hubert Curien Laboratory (LabHC), Jean Monnet University of Saint-Etienne, France., Capraro S. ,   Hubert Curien Laboratory (LabHC), Jean Monnet University of Saint-Etienne, France., Rousseau J.J. ,   Hubert Curien Laboratory (LabHC), Jean Monnet University of Saint-Etienne, France.
Published: October 2023

This article presents a study on influence of frequency and magnetic material on electrical current density distribution and its intensity in a planar inductor.Studied structures are planar inductors without and with a magnetic material. These studies are performed in simulation using HFSS simulator and in experimental measurement using impedance-meter.
COMPLICATIONS OF ENTEROCYSTOPLASTYCASE SERIES
Authors:   Department of Urology A, Ibn Sina Hospital University of Rabat, Morocco., Lakssir Jihad , El Bote Hicham ,   Faculty of Medicine and Pharmacy of Beni Mellal, Morocco., Bellouki Omar ,   Department of Urology A, Ibn Sina Hospital University of Rabat, Morocco., Boughaleb Abdelmounim ,   Department of Urology A, Ibn Sina Hospital University of Rabat, Morocco., Ibrahimi Ahmed ,   Department of Urology A, Ibn Sina Hospital University of Rabat, Morocco., El-Sayegh Hachem ,   Department of Urology A, Ibn Sina Hospital University of Rabat, Morocco., Nouini Yassine ,   Department of Urology A, Ibn Sina Hospital University of Rabat, Morocco.
Published: October 2023

Radical cystectomy is the reference treatment for infiltrating bladder tumors or those that escape local treatment. A urinary diversion is then necessary, enterocystoplasty has become, when possible, the preferred choice of urologists because of its advantage of respecting the body schema of the patients and offering them a natural micturition. We present a series of 50 patients who underwent enterocystoplasty as a urinary diversion over a period of 20 years, performed by the Department of Urology A at Ibn Sina hospital university, while specifying early and late complications related to this procedure as well as it functional results.
A COMPARATIVE STUDY OF E-WASTE MANAGEMENT POLICIES IN INDIA AND THE EUROPEAN UNION
Authors: Mani Krithika
Published: October 2023

A grave consequence of the digital revolution and technologys mass proliferation into society is the e-waste left in its wake, as effective management of the same has manifested as a dire problem. This comparative analysis of the e-waste management processes in two seemingly distinct parts of the world: India and the European Union is based on research into Indias E-Waste Management Rules (2022) and European Unions RoHS Directive (2011) and WEEE Directive (2012). It explores the scope of these policies, their implementation frameworks, the stakeholders involved, and their respective responsibilities, while illustrating the need to enhance global e-waste management processes. The paper is centred around various interpretations drawn from this initial research. The first is a comparison between India and the EUs policies therefore providing insight into the role of regional and contextual elements in influencing policy implementation in e-waste management. This paper further provides radical suggestions to enhance the e-waste management processes in both EU and India - thus addressing both overarching frameworks and grassroot level concerns while keeping in mind demographic differences between the two. This papers conclusive findings hope to spearhead new, effective approaches to e-waste management thus outlining the need for global interaction in e-waste management and urging collective efforts to establish unified practices to safeguard our environment in the present and preserve it for the future.
DECUBITUS COMPLICATIONS IN BURN PATIENTS
Authors:   Department of Reconstructive, Plastic and Burn Surgery., Fifatin E. , Atiqui O.E ,   Department of Reconstructive, Plastic and Burn Surgery., Sylla S. ,   Department of Reconstructive, Plastic and Burn Surgery., Sahir M. ,   Department of Reconstructive, Plastic and Burn Surgery., Marzak M. ,   Department of Reconstructive, Plastic and Burn Surgery., Benlaaguid K. ,   Department of Reconstructive, Plastic and Burn Surgery., Amrani MD ,   Department of Reconstructive, Plastic and Burn Surgery., Benchamkha Y. ,   Department of Reconstructive, Plastic and Burn Surgery.
Published: October 2023

The complications related to immobilization, include pressure sores and thromboembolic complications.The risk of these complications is increased in burn patients in general, and more precisely in severe burn patients, but it remains underestimated by practitioners.Through our study, we will try to highlight these different complications and their incidence in relation to all hospitalized burned patients.It is a retrospective study spread over a period of 3 years, from January 2020 to December 2022, with the aim of drawing up an epidemiological profile. Conclusion: Pressure sores are the most feared complications, despite the wide range of preventive measures implemented to avoid them (change of position, anti-sore mattress, heparin therapy, etc.). This could correlate to the background pain found in almost all burn patients, which would constitute an obstacle to position changes in these patients.
Bayesian Accelerated Failure Time Model for Risk Pregnancy Detection
Authors: Alexander Dennis , Abdullah Sarini , Nurzaman Adam Fahsyah
Published: October 2023

Preeclampsia (PE) also known as a hypertension during third trisemester of pregnancy. PE, is one of the most feared complications of pregnancy because it can potentially become serious complications in the future, including mother and fetus’s death. The goal of this study is other than to have a bettter undestanding about risk factor in pregnancy by modelling the relationship between several factors and the time until deliveries under the PE condition. Data on 924 patients at obstetric and gynecology department in Jakarta were used in the analysis. Accelerated Failure Time (AFT) model was proposed to indentify some risk factors that influenced the condition. Model parameters were estimated using Bayesian method. Due to imbalance data, undersampling method will be used as a pre-procesing stage. Ratio between PE and non-PE data will be 60:40. Flat prior and posterior sample will be used using MCMC simulation with 12,000 iterations (including 2,000 iterations as a burnin stage) to get a convergen result. The iteration was repeated for 100 times so that the chosen data from undersampling was not error and biased. A consistent result for credible interval of the mean result was considered as the factors that affect PE condition consistently. From this study, there are two factors that have consistent Credible Interval result, Body Mass Index (BMI) and Mean Arterial Pressure (MAP).
Analysis and Design of Ticketing Application System (Case Study: Bebek Kaleyo)
Authors: Ngarianto Heri , Mulaputra Ahmad Fikri , Septiany Fanny , Delima Tiara
Published: October 2023

Bebek Kaleyo is a restaurant chain with several outlets in the food business. Information technology (IT) equipment is used extensively in Bebek Kaleyo's operating processes, and any problems with the IT hardware are escalated to the IT department for solutions. However, each restaurant branch's reporting of interruptions is still done by hand. Based on these issues and the analysis, it is necessary to speed up the complaint procedure to guarantee quick repairs of IT equipment and successful execution of tasks. The research was conducted by examining the company's daily activities, and the results were used to develop a ticketing system for monitoring process improvements and reporting interruptions. A ticketing system that facilitates effective reporting of IT issues and monitors process improvements was designed and developed as part of this research using the prototype methodology. The installed ticketing system helps users at each branch report problems, keep track of repairs, and improves the efficiency and quality of service provided by the IT department in support of the supply and use of system and technology-related facilities. By using this ticketing system, Bebek Kaleyo hopes to improve overall process efficiency while streamlining the process of reporting IT concerns. This solution gives branch users the ability to discuss IT issues with the IT department in an efficient manner, which improves the organization's operational performance.
Features of management of patients with cardiometabolic polymorbidity phenotype: focus on the efficacy and safety of bisoprolol
Authors: Polyakova O. A. , Ostroumova O. D.
Published: October 2023

The presence of coexisting chronic non-infectious diseases is associated with reduced quality of life and increased risk of early disability and mortality. The coexistence of two or more diseases in a patient is defined by the term polymorbidity. Currently, there is an increase in polymorbid pathology not only among elderly patients, but also among young and middle-aged people, which entails significant health care costs and has a negative impact on the economy of the country as a whole. Therefore, the problem of polymorbidity and the management of such patients in real clinical practice is urgent and key in the field of public health. According to major foreign and domestic studies, the most common polymorbidity phenotype is the cardiometabolic phenotype. Taking into account the fact that in our country almost every second patient with arterial hypertension has metabolic disorders and, therefore, polymorbid pathology, approaches to the management of such patients should be personalized already from the beginning of drug therapy. In this regard, this review reviews some key pathophysiological mechanisms of the relationship between arterial hypertension and metabolic disturbances occurring in patients with the cardiometabolic phenotype of polymorbidity, presents features of antihypertensive therapy in such patients, in particular, describes in more detail the class of beta-blockers with pathogenetic validity of use in this case. Also, a review of the available clinical trial data concerning the effects of the highly selective beta-adrenoblocker bisoprolol in patients with arterial hypertension is presented, emphasizing its effect on metabolic status and its importance for comprehensive clinical management.
Evaluation of the efficacy and safety of various non-steroidal anti-inflammatory drugs in postmenopausal women with an inflammatory phenotype of osteoarthritis
Authors: Shafieva I. A. , Bulgakova S. V. , Shafieva A. V. , Kurmayev D. P.
Published: October 2023

Introduction. Non-steroidal anti-inflammatory drugs (NSAIDs) are currently the mainstay of the management for relieving pain syndrome in osteoarthritis (OA). NSAIDs are characterized by an individual reaction to medication, as well as a quite high frequency of gastrointestinal side effects. The issue of the disadvantages and advantages of a particular group of NSAIDs is still open.

Aim. To evaluate the safety and efficacy of Meloxicam at a dose of 15 mg/day as compared with Nimesulide and placebo in postmenopausal women with an inflammatory phenotype of OA.

Results and discussion. The frequency of all adverse events was comparable among the group of patients receiving meloxicam (40.0%), and lower than in the nimesulide group (48.0%), but higher than in the placebo group. A decrease in pain syndrome was observed as early as at 2 weeks of treatment in the group of patients receiving meloxicam. A significant decrease in WOMAC scores (overall result, pain syndrome, stiffness, function) was observed in the group of patients receiving meloxicam, and in the group of patients receiving nimesulide, after 3 weeks of treatment. meloxicam and nimesulide demonstrated high efficacy at 3 weeks compared with the initial VAS scores. The placebo group showed no efficacy.

Conclusion. The frequency of all adverse events was lower while taking meloxicam as compared to nimesulide. Our results substantiate the concept to prescribe meloxicam at a dose 15 mg once daily for the treatment of pain and stiffness in post-menopausal women with OA.
Naturally occurring compounds in relieving symptoms and reducing perimenopausal risks
Authors: Shikh E. V. , Makhova A. A.
Published: October 2023

Metabolic disorders that are progressive in nature most significantly influence the health of postmenopausal women. Osteoporosis and cardiovascular diseases are the most important long-term consequences and seriously affect the menopausal women’s quality of life. Hot flashes, a sudden feeling of heat or burning that begins in the face, neck, upper chest or back regions, is a common reason to see a doctor. Sometimes, hot flashes are accompanied by redness of the skin, red blotches, or rapid heartbeat. In some cases, rises in local skin temperature are observed. The above symptoms are the result of impaired functioning of thermosensitive neurons in the hypothalamic region. Menopausal hormone therapy is the gold standard for pharmacotherapy of various menopausal symptoms. However, it has different absolute and relative contraindications, as well as patients’ refusal of treatment mainly due to hormone phobia, that have resulted in a situation where 30% of menopausal women take hormone replacement therapy and only 15% continue to take it for a long period. Patients often insist on a natural approach to symptom relief and need evidence-based information about different hormonal and non-hormonal treatment options. Concerns about potential side effects of the hormone replacement therapy resulted in increased interest rates for phytoestrogens to manage menopausal symptoms. A rational fixed dose combination of phytoestrogens and micronutrients is a well-tolerated alternative preparation to support the health of perimenopausal women, which can be used with virtually no restrictions.
Deep machine learning applied to support clinical decision-making in the treatment of infertility using assisted reproductive technologies
Authors: Drapkina Ju. S. , Makarova N. Р. , Tataurova P. D. , Kalinina E. A.
Published: October 2023

Introduction. Machine learning (ML) applied to data analysis allows to more accurately and targetedly determine the most significant correctable and non-correctable predictors of onset of pregnancy in assisted reproductive technology (ART) programs in patients of different age groups. Analysis of data using various techniques and comparison of results obtained via two models will determine the most significant factors for onset of pregnancy in the ART program.

Aim. To determine the most significant clinical and embryological predictors of onset of pregnancy using standard regression analysis and a decision tree algorithm to predict pregnancy in the ART program.

Materials and methods. A total of 1,021 married couples were included in the retrospective study. The study analysed clinical and laboratory test findings and stimulated cycle parameters depending on the effectiveness of the ART program. A regression analysis was carried out and a decision tree algorithm was built using the Gini criterion to determine the most significant factors.

Results. We identified “general” signs that require further validation on other models, including ML: the presence/absence of a history of pregnancies, stimulated cycle parameters (oocyte cumulus complex, number of metaphase II (MII) oocytes, number of zygotes), spermogram indicators on the day of puncture, number of high and good quality embryos, as well as the embryo grading.

Conclusion. rFSH (follitropin-alpha, Gonal-f) gives a significant result in two of the five available age groups, follitropin-beta, corifollitropin alfa – in one of the five groups only. Building a model that includes not only the couple’s medical history data, but also molecular markers using machine learning methods will not only allow us to most accurately determine the most promising groups of patients for in vitro fertilization (IVF) programs, but also increase the efficiency of ART programs by selecting the highest quality embryo to be transferred.
Analysis High Order Level Thinking Skills of High School Students in Chemistry Learning
Authors: Marlina Marlina , Hadi Samsul , Rahim Abdul
Published: October 2023

This study aims to describe the high-order thinking skills of high school students. The research method used is a descriptive method with a quantitative approach. The sampling technique used was the random sampling technique. The research subjects were 488 high school students. The data collection technique is a two-tier multiple choice test consisting of twenty questions covering analyzing, evaluating, and creating. Based on the research results and discussion, high-order thinking skills of high school students showed an average in the very high category with a percentage of 1.8% with a frequency of 9 students. The ability of students in the high category has a percentage of 19.9%, with a frequency of 97 students and the ability of students in the medium category is 49%, with a frequency of 239 students. Meanwhile, the average in the low category is 21.9%, with a frequency of 107 students and the ability of students in the very low category has a percentage of 7.4% with a frequency of 36 students. Overall, high-order thinking skills in high school in Tegal are in the medium category.
Sobre a dúplice tecnológica como instrumento de manutenção e legitimação da memória institucional
Authors: Alex Medeiros Kornalewski
Published: October 2023

O presente trabalho disserta sobre a tecnologia em sua dúplice: a primária, que denota o saber-fazer, a construção de conhecimento inerente ao sujeito; a secundária, sendo esta verificada nos múltiplos suportes, tais como aparelhos físicos e virtuais do campo da informática. A metodologia aplicada é o estudo de caso comparado, somado com o viés empírico, sobre: as tipologias documentais disponíveis na biblioteca especializada da Escola de Cinema Darcy Ribeiro (ECDR) e o acervo majoritariamente eletrônico disponível no Observatório sobre as Estratégias da Indústria do Tabaco, do Centro de Estudos sobre Tabaco e Saúde (Cetab) da Escola Nacional de Saúde Pública, na Fundação Oswaldo Cruz. O processo de automação da biblioteca com o software BNWeb (correspondente à ECDR) e o instrumento Google Analytics (correspondente ao observatório) foram considerados na presente análise. A experiência, vista como suporte mnésico, para prover uma reflexão entre as duas nuanças tecnológicas, demonstra o quanto as tecnologias, em seu sentido lato, promovem transformações no tocante à memória institucional, sendo o efeito dessas tecnologias verificado pelos softwares supracitados. Em suma, o entrelaçamento da tecnologia primária com a secundária se mostra como pilar principal à permanência e à promoção das respectivas instituições.
Gestão de traumatismo dentário segundo a International Association of Dental Traumatology (IADT): atualizações recentes
Authors: Luis Henrique Gabardo  , Liliane Roskamp  , Natanael Henrique Mattos  , Flares Baratto-Filho  , Maria Carolina Botelho Pires de Campos  , Camila Paiva Perin
Published: October 2023

O trauma dentário é considerado um problema de saúde pública em todo o mundo, por conta de sua alta taxa de prevalência, do impacto psicossocial e, na maioria dos casos, do alto custo de tratamento. Sua maior incidência é em crianças e adolescentes, porém adultos também se envolvem em situações que podem levar a injúria. Objetivo: Dentre as injúrias estudadas neste estudo comparativo entre os dois últimos protocolos desenvolvidos pela International Association of Dental Traumatology (IADT), em 2012 e 2020, estão: fraturas corono-radiculares, fratura radicular, concussão e subluxação, extrusão, luxação lateral e intrusão. Assim, o objetivo do presente estudo é proporcionar conhecimento sobre esses tipos de trauma dentário e a sua conduta atual e adequada, assim como indicar suas possíveis sequelas. Material e métodos: Foram pesquisadas as diretrizes da IADT publicadas nos anos 2012 e 2020 e selecionaram-se artigos relacionados a traumatismos alveolodentários utilizando as palavras: guidelines and dental trauma, tooth concussion, tooth luxation, dental fracture, root fracture, tooth extrusion and tooth intrusion. Casos de avulsão dentária não foram incluídos, em virtude dos protocolos individuais que recebem pela IADT. Os dados foram organizados em tabelas, no Microsoft Excel, para uma melhor visualização e entendimento. Resultados: As mudanças mais importantes apresentadas nos protocolos de 2020 estão relacionadas aos casos de intrusão dentária. Conclusão: Os protocolos de tratamento do dente traumatizado indicado pela IADT 2020 devem ser de conhecimento do cirurgião-dentista para que o melhor método seja encontrado e instituído em cada caso de traumatismo alveolodentário, principalmente em casos de luxação intrusiva.
A cirurgia ortognática influencia na qualidade de vida?
Authors: Bruna Luiza Piovesan Santana  , Rita Tonocchi  , Camila de Castro Corrêa  , Cristiano Miranda de Araujo  , Bianca Lopes Cavalcante Leão
Published: October 2023

Avaliar o impacto da cirurgia ortognática na qualidade de vida em deformidade dentofacial, comparando com o momento cirúrgico e tipo de maloclusão. Material e métodos: 249 participantes preencheram, de agosto a setembro de 2020, o protocolo de qualidade de vida (WHOQOL-bref) composto por 26 itens divididos em quatro domínios (físico, psicológico, relações sociais e meio ambiente), além do escore global. A análise foi realizada pelo teste de Anova a dois critérios, considerando o nível de significância de 5%. Resultados: A queixa mais reportada foi relacionada à estética (54,3%). Houve aumento da qualidade de vida após a cirurgia ortognática para todos os domínios. Considerando o tipo de maloclusão, os participantes com classe III demonstraram maior impacto na qualidade de vida. Conclusão: Verificou-se aumento na qualidade de vida no momento pós-cirúrgico, principalmente nos aspectos físicos. Considerando o tipo de maloclusão, os sujeitos classe III evidenciaram maior ganho na qualidade de vida.