bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Thermal and Dielectric Loss Features of Lunar Regolith Considering Real‐Time Effect Solar Irradiance
Authors: Chen Shurui , Feng Yongjiu , Tong Xiaohua , Tang Panli , Yang Qiquan , Xiao Changjiang , Xu Xiong , Wang Chao , Jin Yanmin
Published: July 2024

Solar irradiance received at the lunar surface is crucial for interpreting brightness temperatures detected by orbiters and for understanding the thermal, physical, and dielectric properties of the lunar regolith. We developed a real‐time effect solar irradiance (ESI) model that accounts for the influence of surface relief and terrain shading. This model was integrated with a standard thermal model to examine ESI fluctuations and their impacts on the diurnal physical temperature variations. To assess the effects of spatial resolution, we selected four locations with significant ESI disparities for simulation, then compared lunar surface temperatures at various spatial scales, ranging from 20 m to 25 km. Utilizing brightness temperature data obtained from the Chang'E‐2 (CE‐2) microwave radiometer (MRM), we integrated the shallow physical temperature profiles with the radiative transfer equation to simulate brightness temperatures and determine dielectric loss at different frequencies. In the Von Kármán crater, the received ESI exhibits a cyclical pattern of approximately 18 years and areas with rugged topography may exhibit larger ESI variations (∼7%). We found that the spatial resolution of ESI has a minimal effect on the physical and brightness temperatures at resolutions of 10 km or coarser. At the shallow layer, the average dielectric loss values are 0.0128–0.0170, 0.0083–0.0110, 0.0055–0.0073, and 0.0061–0.0081 for the CE‐2 frequencies of 3, 7.8, 19.35, and 37 GHz, respectively. The integration of real‐time ESI modeling, thermal dynamics, radiative transfer equations, and observational data enhances our comprehension of the physical temperature profile and thermal characteristics of shallow regolith.
Reactive Barriers Could Keep Nitrate out of the Atlantic
Authors: Soliman Alix
Published: July 2024

Microbes in mulch scrub nitrate from groundwater before it flows to the sea.
A Machine Learning Method to Retrieve Global Rainfall and Snowfall Rates From the Passive Microwave Observations of FY‐3E
Authors: Zhao Runze , Wang Kaicun , Xu Xiangde
Published: July 2024

Passive microwave radiometers onboard satellites rely on the received upwelling radiation to retrieve precipitation, which is a mixed signal from the surface, atmosphere and precipitation hydrometeors. Liquid precipitation droplets increase the upwelling radiation from the surface at lower frequencies, while ice particles cause a decrease in upwelling radiation at higher frequencies. The task of the retrieval algorithm is to identify the precipitation phase and to isolate the signal of precipitation from that of the surface. This study develops a machine learning method to retrieve rainfall and snowfall rates based on observations from the Microwave Hydrometer Sounder and Microwave Temperature Sounder onboard FY‐3E. Self‐organized mapping (SOM) is selected to classify the precipitation and underlying surface types, and an artificial neural network (ANN) is subsequently used to relate the brightness temperature to the precipitation rate for the clusters derived from the SOM. The half‐hour product of the Integrated Multi‐Satellite Retrieval for Global Precipitation Measurement (IMERG) is used to train the ANN. To address the issue that number of heavy precipitation samples are not enough for training, the simulation of radiative transfer for TOVS is used as a supplement to heavy rain samples. The SOM‐ANN algorithm outperforms the IMERG and Goddard profiling algorithm (GPROF) retrieval products in both rainfall and snowfall retrieval. Compared with the hourly observations at ∼4,400 stations during a 2‐year period, the root mean square errors of SOM‐ANN proposed here are 1.06 and 0.34 mm/hr for the rainfall and snowfall rates, which are better than those of IMERG (1.23 and 0.42 mm/hr) and GPROF (1.22 and 0.44 mm/hr).
On the Gravity Wave‐Seeded Ionospheric Irregularities in the Martian Ionosphere
Authors: Tian Rong , Jiang Chunhua , Sánchez‐Cano Beatriz , Yin Wenjie , Yang Guobin , Liu Tongxin , Hu Yaogai
Published: July 2024

For the past few decades, it has been demonstrated that gravity waves (GWs) and neutral winds can drive ionospheric irregularities on Earth. Still, as far as we know, the formation of ionospheric irregularities on Mars due to GWs has not been well studied. In this study, we use data from the NASA's Mars Atmosphere and Volatile Evolution (MAVEN) mission to show evidence of an irregularity event in the Martian ionosphere, potentially seeded by the GWs break (GWB). Statistical findings indicate that the observed ratio of GWB‐related irregularity events varies from ∼0.25 to ∼0.47 each year, and the average ratio in 2015–2020 is ∼0.37. We perform a numerical simulation to provide further insight into the processes behind irregularity formation, which employs neutral wind shear as a source of perturbation in the context of the GWB. The simulations yield results fundamentally aligned with the observed characteristics of ionospheric irregularities in the 2018 event by considering the wind shear as the disturbance source. This study provides supplementary insights into the perturbation sources involved in shaping irregularities within the Martian ionosphere and presents valuable information about the coupling between the Martian ionosphere and the lower atmosphere.
Broadband and fabrication-tolerant 3-dB couplers with topological valley edge modes
Authors: Tang Guo-Jing , Chen Xiao-Dong , Sun Lu , Guo Chao-Heng , Li Meng-Yu , Tian Zhong-Tao , Chen Hou-Hong , Wang Hong-Wei , Sun Qi-Yao , Pan Ying-Di , He Xin-Tao , Su Yi-Kai , Dong Jian-Wen
Published: July 2024

3-dB couplers, which are commonly used in photonic integrated circuits for on-chip information processing, precision measurement, and quantum computing, face challenges in achieving robust performance due to their limited 3-dB bandwidths and sensitivity to fabrication errors. To address this, we introduce topological physics to nanophotonics, developing a framework for topological 3-dB couplers. These couplers exhibit broad working wavelength range and robustness against fabrication dimensional errors. By leveraging valley-Hall topology and mirror symmetry, the photonic-crystal-slab couplers achieve ideal 3-dB splitting characterized by a wavelength-insensitive scattering matrix. Tolerance analysis confirms the superiority on broad bandwidth of 48 nm and robust splitting against dimensional errors of 20 nm. We further propose a topological interferometer for on-chip distance measurement, which also exhibits robustness against dimensional errors. This extension of topological principles to the fields of interferometers, may open up new possibilities for constructing robust wavelength division multiplexing, temperature-drift-insensitive sensing, and optical coherence tomography applications.
Association between oral hygiene knowledge and practices among older dental patients attending private dental clinics in Addis Ababa, Ethiopia
Authors: Mulatu Yemisrach , Mehdi Mohammed , Abaynew Yeshewas
Published: July 2024

Background

Ensuring optimal oral hygiene is crucial for preserving the well-being of hard and soft tissues within the oral system. A lack of proper oral hygiene can have a detrimental impact on an individual’s health, leading to conditions such as caries and periodontitis. Therefore, this study investigated the association between the knowledge and practices of older patients in oral hygiene in Addis Ababa, Ethiopia.

Methods

A facility-based cross-sectional study was carried out on 111 older patients who presented at purposively selected dental clinics in Addis Ababa. A convenience sampling method was used to recruit study participants. The data were collected using a pretested structured questionnaire. The questionnaire included information related to the patient’s knowledge and practices related to oral hygiene. The data were analyzed using SPSS version 23. Descriptive statistics were used to analyze the data. Multivariate logistic regression was performed to investigate the associations between independent and dependent variables. Adjusted odds ratios with 95% confidence intervals (95% CIs) were estimated, and variables with a p value < 0.05 in the multivariate analysis were considered significant.

Results

The median age of the study participants was 70.31 years (65–100). Inadequate oral hygiene knowledge was found in 53.15% of the participants, while more than three-quarters (83.78%) of the older participants practiced poor oral hygiene. Older patients with good oral hygiene knowledge were 7.6 times more likely to practice good oral hygiene practices (AOR, 7.6; 95% CI (2.05–27.9)).

Conclusions

Poor oral health is significantly associated with various health problems, particularly in older people. This study examined the relationship between oral health knowledge and practices in older dental patients and revealed insufficient knowledge and practices among participants. The results showed a notable link between oral health knowledge and practices in this demographic group, highlighting the need for support to improve oral health status. Organizations should increase awareness among older patients to improve their oral health status.
Myeloid-derived suppressor cells-induced exhaustion of CD8 + T-cell participates in rejection after liver transplantation
Authors: Zhou Liu-Xin , Jiang Yi-Zhou , Li Xin-Qiang , Zhang Jin-Ming , Li Shi-Peng , Wei Lin , Zhang Hai-Ming , Zhou Guang-Peng , Chen Xiao-Jie , Sun Li-Ying , Zhu Zhi-Jun
Published: July 2024

Liver transplantation (LT) rejection remains the most pervasive problem associated with this procedure, while the mechanism involved is still complicated and undefined. One promising solution may involve the use of myeloid-derived suppressor cells (MDSC). However, the immunological mechanisms underlying the effects of MDSC after LT remain unclear. This study is meant to clarify the role MDSCs play after liver transplantation. In this study, we collected liver tissue and peripheral blood mononuclear cells (PBMC) from LT patients showing varying degrees of rejection, as well as liver and spleen tissue samples from mice LT models. These samples were then analyzed using flow cytometry, immunohistochemistry and multiple immunofluorescence. M-MDSCs and CD8 + T-cells extracted from C57/BL6 mice were enriched and cocultured for in vitro experiments. Results, as obtained in both LT patients and LT mice model, revealed that the proportion and frequency of M-MDSC and PD-1 + T-cells increased significantly under conditions associated with a high degree of LT rejection. Within the LT rejection group, our immunofluorescence results showed that a close spatial contiguity was present between PD-1 + T-cells and M-MDSCs in these liver tissue samples and the proportion of CD84/PD-L1 double-positive M-MDSC was greater than that of G-MDSC. There was a positive correlation between the activity of CD84 and immunosuppressive function of M-MDSCs including PD-L1 expression and reactive oxygen species (ROS) production, as demonstrated in our in vitro model. M-MDSCs treated with CD84 protein were able to induce co-cultured CD8 + T-cells to express high levels of exhaustion markers. We found that CD84 regulated M-MDSC function via expression of PD-L1 through activation of the Akt/Stat3 pathway. These results suggest that the capacity for CD84 to regulate M-MDSC induction of CD8 + T-cell exhaustion may play a key role in LT rejection. Such findings provide important, new insights into the mechanisms of tolerance induction in LT.
Neoadjuvant and adjuvant pembrolizumab in advanced high-grade serous carcinoma: the randomized phase II NeoPembrOV clinical trial
Authors: Ray-Coquard Isabelle L. , Savoye Aude-Marie , Schiffler Camille , Mouret-Reynier Marie-Ange , Derbel Olfa , Kalbacher Elsa , LeHeurteur Marianne , Martinez Alejandra , Cornila Corina , Martinez Mathilde , Bengrine Lefevre Leila , Priou Frank , Cloarec Nicolas , Venat Laurence , Selle Frédéric , Berton Dominique , Collard Olivier , Coquan Elodie , Le Saux Olivia , Treilleux Isabelle , Gouerant Sophie , Angelergues Antoine , Joly Florence , Tredan Olivier
Published: July 2024

This open-label, non-comparative, 2:1 randomized, phase II trial (NCT03275506) in women with stage IIIC/IV high-grade serous carcinoma (HGSC) for whom upfront complete resection was unachievable assessed whether adding pembrolizumab (200 mg every 3 weeks) to standard-of-care carboplatin plus paclitaxel yielded a complete resection rate (CRR) of at least 50%. Postoperatively patients continued assigned treatment for a maximum of 2 years. Postoperative bevacizumab was optional. The primary endpoint was independently assessed CRR at interval debulking surgery. Secondary endpoints were Completeness of Cytoreduction Index (CCI) and peritoneal cancer index (PCI) scores, objective and best response rates, progression-free survival, overall survival, safety, postoperative morbidity, and pathological complete response. The CRR in 61 pembrolizumab-treated patients was 74% (one-sided 95% CI = 63%), exceeding the prespecified ≥50% threshold and meeting the primary objective. The CRR without pembrolizumab was 70% (one-sided 95% CI = 54%). In the remaining patients CCI scores were ≥3 in 27% of the standard-of-care group and 18% of the investigational group and CC1 in 3% of the investigational group. PCI score decreased by a mean of 9.6 in the standard-of-care group and 10.2 in the investigational group. Objective response rates were 60% and 72%, respectively, and best overall response rates were 83% and 90%, respectively. Progression-free survival was similar with the two regimens (median 20.8 versus 19.4 months in the standard-of-care versus investigational arms, respectively) but overall survival favored pembrolizumab-containing therapy (median 35.3 versus 49.8 months, respectively). The most common grade ≥3 adverse events with pembrolizumab-containing therapy were anemia during neoadjuvant therapy and infection/fever postoperatively. Pembrolizumab was discontinued prematurely because of adverse events in 23% of pembrolizumab-treated patients. Combining pembrolizumab with neoadjuvant chemotherapy is feasible for HGSC considered not completely resectable; observed activity in some subgroups justifies further evaluation to improve understanding of the role of immunotherapy in HGSC.
Immunomic longitudinal profiling of the NeoPembrOv trial identifies drivers of immunoresistance in high-grade ovarian carcinoma
Authors: Le Saux Olivia , Ardin Maude , Berthet Justine , Barrin Sarah , Bourhis Morgane , Cinier Justine , Lounici Yasmine , Treilleux Isabelle , Just Pierre-Alexandre , Bataillon Guillaume , Savoye Aude-Marie , Mouret-Reynier Marie-Ange , Coquan Elodie , Derbel Olfa , Jeay Louis , Bouizaguen Suliman , Labidi-Galy Intidhar , Tabone-Eglinger Séverine , Ferrari Anthony , Thomas Emilie , Ménétrier-Caux Christine , Tartour Eric , Galy-Fauroux Isabelle , Stern Marc-Henri , Terme Magali , Caux Christophe , Dubois Bertrand , Ray-Coquard Isabelle
Published: July 2024

PD-1/PD-L1 blockade has so far shown limited survival benefit for high-grade ovarian carcinomas. By using paired samples from the NeoPembrOv randomized phase II trial (NCT03275506), for which primary outcomes are published, and by combining RNA-seq and multiplexed immunofluorescence staining, we explore the impact of NeoAdjuvant ChemoTherapy (NACT) ± Pembrolizumab (P) on the tumor environment, and identify parameters that correlated with response to immunotherapy as a pre-planned exploratory analysis. Indeed, i) combination therapy results in a significant increase in intraepithelial CD8+PD-1+ T cells, ii) combining endothelial and monocyte gene signatures with the CD8B/FOXP3 expression ratio is predictive of response to NACT + P with an area under the curve of 0.93 (95% CI 0.85-1.00) and iii) high CD8B/FOXP3 and high CD8B/ENTPD1 ratios are significantly associated with positive response to NACT + P, while KDR and VEGFR2 expression are associated with resistance. These results indicate that targeting regulatory T cells and endothelial cells, especially VEGFR2+ endothelial cells, could overcome immune resistance of ovarian cancers.
Laser nanofabrication inside silicon with spatial beam modulation and anisotropic seeding
Authors: Asgari Sabet Rana , Ishraq Aqiq , Saltik Alperen , Bütün Mehmet , Tokel Onur
Published: July 2024

Nanofabrication in silicon, arguably the most important material for modern technology, has been limited exclusively to its surface. Existing lithography methods cannot penetrate the wafer surface without altering it, whereas emerging laser-based subsurface or in-chip fabrication remains at greater than 1 μm resolution. In addition, available methods do not allow positioning or modulation with sub-micron precision deep inside the wafer. The fundamental difficulty of breaking these dimensional barriers is two-fold, i.e., complex nonlinear effects inside the wafer and the inherent diffraction limit for laser light. Here, we overcome these challenges by exploiting spatially-modulated laser beams and anisotropic feedback from preformed subsurface structures, to establish controlled nanofabrication capability inside silicon. We demonstrate buried nanostructures of feature sizes down to 100 ± 20 nm, with subwavelength and multi-dimensional control; thereby improving the state-of-the-art by an order-of-magnitude. In order to showcase the emerging capabilities, we fabricate nanophotonics elements deep inside Si, exemplified by nanogratings with record diffraction efficiency and spectral control. The reported advance is an important step towards 3D nanophotonics systems, micro/nanofluidics, and 3D electronic-photonic integrated systems.
Rational correction of pathogenic conformational defects in HTRA1
Authors: Beaufort Nathalie , Ingendahl Linda , Merdanovic Melisa , Schmidt Andree , Podlesainski David , Richter Tim , Neumann Thorben , Kuszner Michael , Vetter Ingrid R. , Stege Patricia , Burston Steven G. , Filipovic Anto , Ruiz-Blanco Yasser B. , Bravo-Rodriguez Kenny , Mieres-Perez Joel , Beuck Christine , Uebel Stephan , Zobawa Monika , Schillinger Jasmin , Malik Rainer , Todorov-Völgyi Katalin , Rey Juliana , Roberti Annabell , Hagemeier Birte , Wefers Benedikt , Müller Stephan A. , Wurst Wolfgang , Sanchez-Garcia Elsa , Zimmermann Alexander , Hu Xiao-Yu , Clausen Tim , Huber Robert , Lichtenthaler Stefan F. , Schmuck Carsten , Giese Michael , Kaiser Markus , Ehrmann Michael , Dichgans Martin
Published: July 2024

Loss-of-function mutations in the homotrimeric serine protease HTRA1 cause cerebral vasculopathy. Here, we establish independent approaches to achieve the functional correction of trimer assembly defects. Focusing on the prototypical R274Q mutation, we identify an HTRA1 variant that promotes trimer formation thus restoring enzymatic activity in vitro. Genetic experiments in Htra1R274Q mice further demonstrate that expression of this protein-based corrector in trans is sufficient to stabilize HtrA1-R274Q and restore the proteomic signature of the brain vasculature. An alternative approach employs supramolecular chemical ligands that shift the monomer-trimer equilibrium towards proteolytically active trimers. Moreover, we identify a peptidic ligand that activates HTRA1 monomers. Our findings open perspectives for tailored protein repair strategies.
Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice
Authors: Liu Ze-Long , Li Yan , Lin Yi-Jun , Shi Mao-Mao , Fu Meng-Xia , Li Zhi-Qing , Ning Da-Sheng , Zeng Xiang-Ming , Liu Xiang , Cui Qing-Hua , Peng Yue-Ming , Zhou Xin-Min , Hu Ye-Rong , Liu Jia-Sheng , Liu Yu-Jia , Wang Mian , Zhang Chun-Xiang , Kong Wei , Ou Zhi-Jun , Ou Jing-Song
Published: July 2024

The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 participants were recruited for the screening of differentially expressed plasma microRNAs (miRNAs). We found that miR-1204 is significantly increased in both the plasma and aorta of elder patients with AAD and is positively correlated with age. Cell senescence induces the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induces vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. Furthermore, miR-1204 aggravates angiotensin II-induced AAD formation, and inhibition of miR-1204 attenuates β-aminopropionitrile monofumarate-induced AAD development in mice. Mechanistically, miR-1204 directly targets myosin light chain kinase (MYLK), leading to the acquisition of a senescence-associated secretory phenotype (SASP) by VSMCs and loss of their contractile phenotype. MYLK overexpression reverses miR-1204-induced VSMC senescence, SASP and contractile phenotypic changes, and the decrease of transforming growth factor-β signaling pathway. Our findings suggest that aging aggravates AAD via the miR-1204-MYLK signaling axis.
Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture
Authors: Braga Alice , Chiacchiaretta Martina , Pellerin Luc , Kong Dong , Haydon Philip G.
Published: July 2024

Neuronal activity undergoes significant changes during vigilance states, accompanied by an accommodation of energy demands. While the astrocyte-neuron lactate shuttle has shown that lactate is the primary energy substrate for sustaining neuronal activity in multiple brain regions, its role in regulating sleep/wake architecture is not fully understood. Here we investigated the involvement of astrocytic lactate supply in maintaining consolidated wakefulness by downregulating, in a cell-specific manner, the expression of monocarboxylate transporters (MCTs) in the lateral hypothalamus of transgenic mice. Our results demonstrate that reduced expression of MCT4 in astrocytes disrupts lactate supply to wake-promoting orexin neurons, impairing wakefulness stability. Additionally, we show that MCT2-mediated lactate uptake is necessary for maintaining tonic firing of orexin neurons and stabilizing wakefulness. Our findings provide both in vivo and in vitro evidence supporting the role of astrocyte-to-orexinergic neuron lactate shuttle in regulating proper sleep/wake stability.
Rapid meiotic prophase chromosome movements in Arabidopsis thaliana are linked to essential reorganization at the nuclear envelope
Authors: Cromer Laurence , Tiscareno-Andrade Mariana , Lefranc Sandrine , Chambon Aurélie , Hurel Aurélie , Brogniez Manon , Guérin Julie , Le Masson Ivan , Adam Gabriele , Charif Delphine , Andrey Philippe , Grelon Mathilde
Published: July 2024

Meiotic rapid prophase chromosome movements (RPMs) require connections between the chromosomes and the cytoskeleton, involving SUN (Sad1/UNC-84)-domain-containing proteins at the inner nuclear envelope (NE). RPMs remain significantly understudied in plants, with respect to their importance in the regulation of meiosis. Here, we demonstrate that Arabidopsis thaliana meiotic centromeres undergo rapid (up to 500 nm/s) and uncoordinated movements during the zygotene and pachytene stages. These centromere movements are not affected by altered chromosome organization and recombination but are abolished in the double mutant sun1 sun2. We also document the changes in chromosome dynamics and nucleus organization during the transition from leptotene to zygotene, including telomere attachment to SUN-enriched NE domains, bouquet formation, and nucleolus displacement, all of which were defective in sun1 sun2. These results establish A. thaliana as a model species for studying the functional implications of meiotic RPMs and demonstrate the mechanistic conservation of telomere-led RPMs in plants.
Antibody Fc-receptor FcεR1γ stabilizes cell surface receptors in group 3 innate lymphoid cells and promotes anti-infection immunity
Authors: Huang Chao , Zhu Wenting , Li Qing , Lei Yuchen , Chen Xi , Liu Shaorui , Chen Dianyu , Zhong Lijian , Gao Feng , Fu Shujie , He Danyang , Li Jinsong , Xu Heping
Published: July 2024

Group 3 innate lymphoid cells (ILC3) are crucial for maintaining mucosal homeostasis and regulating inflammatory diseases, but the molecular mechanisms governing their phenotype and function are not fully understood. Here, we show that ILC3s highly express Fcer1g gene, which encodes the antibody Fc-receptor common gamma chain, FcεR1γ. Genetic perturbation of FcεR1γ leads to the absence of critical cell membrane receptors NKp46 and CD16 in ILC3s. Alanine scanning mutagenesis identifies two residues in FcεR1γ that stabilize its binding partners. FcεR1γ expression in ILC3s is essential for effective protective immunity against bacterial and fungal infections. Mechanistically, FcεR1γ influences the transcriptional state and proinflammatory cytokine production of ILC3s, relying on the CD16-FcεR1γ signaling pathway. In summary, our findings highlight the significance of FcεR1γ as an adapter protein that stabilizes cell membrane partners in ILC3s and promotes anti-infection immunity.
Simultaneous control of carrier transport and film polarization of emission layers aimed at high-performance OLEDs
Authors: Tanaka Masaki , Chan Chin-Yiu , Nakanotani Hajime , Adachi Chihaya
Published: July 2024

The orientation of a permanent dipole moment during vacuum deposition results in the occurrence of spontaneous orientation polarization (SOP). Previous studies reported that the presence of SOP in organic light-emitting diodes (OLEDs) lowers electroluminescence efficiency because electrically generated excitons are seriously quenched by SOP-induced accumulated charges. Thus, the SOP in a host:guest-based emission layer (EML) should be finely controlled. In this study, we demonstrate the positive effect of dipole-dipole interactions between polar host and polar emitter molecules on the OLED performance. We found that a small-sized polar host molecule that possesses both high molecular diffusivities and moderate permanent dipole moment, well cancels out the polarization formed by the SOP of the emitter molecules in the EML without a disturbance of the emitter molecules’ intrinsic orientation, leading to high-performance of OLEDs. Our molecular design strategy will allow emitter molecules to pull out the full potential of the EMLs in OLEDs.
Spin occupancy regulation of the Pt d-orbital for a robust low-Pt catalyst towards oxygen reduction
Authors: Xue Dongping , Yuan Yifang , Yu Yue , Xu Siran , Wei Yifan , Zhang Jiaqi , Guo Haizhong , Shao Minhua , Zhang Jia-Nan
Published: July 2024

Disentangling the limitations of O-O bond activation and OH* site-blocking effects on Pt sites is key to improving the intrinsic activity and stability of low-Pt catalysts for the oxygen reduction reaction (ORR). Herein, we integrate of PtFe alloy nanocrystals on a single-atom Fe-N-C substrate (PtFe@FeSAs-N-C) and further construct a ferromagnetic platform to investigate the regulation behavior of the spin occupancy state of the Pt d-orbital in the ORR. PtFe@FeSAs-N-C delivers a mass activity of 0.75 A mgPt−1 at 0.9 V and a peak power density of 1240 mW cm−2 in the fuel-cell, outperforming the commercial Pt/C catalyst, and a mass activity retention of 97%, with no noticeable current drop at 0.6 V for more than 220 h, is attained. Operando spectroelectrochemistry decodes the orbital interaction mechanism between the active center and reaction intermediates. The Pt dz2 orbital occupation state is regulated to t2g6eg3 by spin-charge injection, suppressing the OH* site-blocking effect and effectively inhibiting H2O2 production. This work provides valuable insights into designing high-performance and low-Pt catalysts via spintronics-level engineering.
A cryogenic on-chip microwave pulse generator for large-scale superconducting quantum computing
Authors: Bao Zenghui , Li Yan , Wang Zhiling , Wang Jiahui , Yang Jize , Xiong Haonan , Song Yipu , Wu Yukai , Zhang Hongyi , Duan Luming
Published: July 2024

For superconducting quantum processors, microwave signals are delivered to each qubit from room-temperature electronics to the cryogenic environment through coaxial cables. Limited by the heat load of cabling and the massive cost of electronics, such an architecture is not viable for millions of qubits required for fault-tolerant quantum computing. Monolithic integration of the control electronics and the qubits provides a promising solution, which, however, requires a coherent cryogenic microwave pulse generator that is compatible with superconducting quantum circuits. Here, we report such a signal source driven by digital-like signals, generating pulsed microwave emission with well-controlled phase, intensity, and frequency directly at millikelvin temperatures. We showcase high-fidelity readout of superconducting qubits with the microwave pulse generator. The device demonstrated here has a small footprint, negligible heat load, great flexibility to operate, and is fully compatible with today’s superconducting quantum circuits, thus providing an enabling technology for large-scale superconducting quantum computers.
Phosphoribosylpyrophosphate synthetase as a metabolic valve advances Methylobacterium/Methylorubrum phyllosphere colonization and plant growth
Authors: Zhang Cong , Zhou Di-Fei , Wang Meng-Ying , Song Ya-Zhen , Zhang Chong , Zhang Ming-Ming , Sun Jing , Yao Lu , Mo Xu-Hua , Ma Zeng-Xin , Yuan Xiao-Jie , Shao Yi , Wang Hao-Ran , Dong Si-Han , Bao Kai , Lu Shu-Huan , Sadilek Martin , Kalyuzhnaya Marina G. , Xing Xin-Hui , Yang Song
Published: July 2024

The proficiency of phyllosphere microbiomes in efficiently utilizing plant-provided nutrients is pivotal for their successful colonization of plants. The methylotrophic capabilities of Methylobacterium/Methylorubrum play a crucial role in this process. However, the precise mechanisms facilitating efficient colonization remain elusive. In the present study, we investigate the significance of methanol assimilation in shaping the success of mutualistic relationships between methylotrophs and plants. A set of strains originating from Methylorubrum extorquens AM1 are subjected to evolutionary pressures to thrive under low methanol conditions. A mutation in the phosphoribosylpyrophosphate synthetase gene is identified, which converts it into a metabolic valve. This valve redirects limited C1-carbon resources towards the synthesis of biomass by up-regulating a non-essential phosphoketolase pathway. These newly acquired bacterial traits demonstrate superior colonization capabilities, even at low abundance, leading to increased growth of inoculated plants. This function is prevalent in Methylobacterium/Methylorubrum strains. In summary, our findings offer insights that could guide the selection of Methylobacterium/Methylorubrum strains for advantageous agricultural applications.
Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3
Authors: Chen Jingying , Ding Jing , Li Yongyu , Feng Fujuan , Xu Yuhang , Wang Tao , He Jianbo , Cang Jing , Luo Lingfei
Published: July 2024

In zebrafish, brain lymphatic endothelial cells (BLECs) are essential for meningeal angiogenesis and cerebrovascular regeneration. Although epidermal growth factor-like domain 7 (Egfl7) has been reported to act as a pro-angiogenic factor, its roles in lymphangiogenesis remain unclear. Here, we show that Egfl7 is expressed in both blood and lymphatic endothelial cells. We generate an egfl7cq180 mutant with a 13-bp-deletion in exon 3 leading to reduced expression of Egfl7. The egfl7cq180 mutant zebrafish exhibit defective formation of BLEC bilateral loop-like structures, although trunk and facial lymphatic development remains unaffected. Moreover, while the egfl7cq180 mutant displays normal BLEC lineage specification, the migration and proliferation of these cells are impaired. Additionally, we identify integrin αvβ3 as the receptor for Egfl7. αvβ3 is expressed in the CVP and sprouting BLECs, and blocking this integrin inhibits the formation of BLEC bilateral loop-like structures. Thus, this study identifies a role for Egfl7 in BLEC development that is mediated through the integrin αvβ3.
Divergent evolution of male-determining loci on proto-Y chromosomes of the housefly
Authors: Li Xuan , Visser Sander , Son Jae Hak , Geuverink Elzemiek , Kıvanç Ece Naz , Wu Yanli , Schmeing Stephan , Pippel Martin , Anvar Seyed Yahya , Schenkel Martijn A. , Marec František , Robinson Mark D. , Meisel Richard P. , Wimmer Ernst A. , van de Zande Louis , Bopp Daniel , Beukeboom Leo W.
Published: July 2024

Houseflies provide a good experimental model to study the initial evolutionary stages of a primary sex-determining locus because they possess different recently evolved proto-Y chromosomes that contain male-determining loci (M) with the same male-determining gene, Mdmd. We investigate M-loci genomically and cytogenetically revealing distinct molecular architectures among M-loci. M on chromosome V (MV) has two intact Mdmd copies in a palindrome. M on chromosome III (MIII) has tandem duplications containing 88 Mdmd copies (only one intact) and various repeats, including repeats that are XY-prevalent. M on chromosome II (MII) and the Y (MY) share MIII-like architecture, but with fewer repeats. MY additionally shares MV-specific sequence arrangements. Based on these data and karyograms using two probes, one derives from MIII and one Mdmd-specific, we infer evolutionary histories of polymorphic M-loci, which have arisen from unique translocations of Mdmd, embedded in larger DNA fragments, and diverged independently into regions of varying complexity.
RNF213 promotes Treg cell differentiation by facilitating K63-linked ubiquitination and nuclear translocation of FOXO1
Authors: Yang Xiaofan , Zhu Xiaotong , Sheng Junli , Fu Yuling , Nie Dingnai , You Xiaolong , Chen Yitian , Yang Xiaodan , Ling Qiao , Zhang Huili , Li Xiaomin , Hu Shengfeng
Published: July 2024

Autoreactive CD4+ T helper cells are critical players that orchestrate the immune response both in multiple sclerosis (MS) and in other neuroinflammatory autoimmune diseases. Ubiquitination is a posttranslational protein modification involved in regulating a variety of cellular processes, including CD4+ T cell differentiation and function. However, only a limited number of E3 ubiquitin ligases have been characterized in terms of their biological functions, particularly in CD4+ T cell differentiation and function. In this study, we found that the RING finger protein 213 (RNF213) specifically promoted regulatory T (Treg) cell differentiation in CD4+ T cells and attenuated autoimmune disease development in an FOXO1-dependent manner. Mechanistically, RNF213 interacts with Forkhead Box Protein O1 (FOXO1) and promotes nuclear translocation of FOXO1 by K63-linked ubiquitination. Notably, RNF213 expression in CD4+ T cells was induced by IFN-β and exerts a crucial role in the therapeutic efficacy of IFN-β for MS. Together, our study findings collectively emphasize the pivotal role of RNF213 in modulating adaptive immune responses. RNF213 holds potential as a promising therapeutic target for addressing disorders associated with Treg cells.
Transient behavior of oxide fuels with controlled microstructure and Cr2O3 additive
Authors: Zhao Dong , Ban Heng , Yang Kun , Broussard Andre , Li Mingxin , Lahoda Edward J. , Lian Jie
Published: July 2024

Microstructure and Cr2O3 doping profoundly impact the thermal-mechanical properties and fracture of oxides fuels. It is a challenge to study the transient behavior of nuclear fuels under loss-of-coolant-event (LOCA). In this study, the crack behavior of UO2 pellets with controlled grain structure and Cr2O3 doping was tested with rapid power ramping (300−900 °C per min) mimicking a prototypical LOCA heating profile. Dense micron-sized UO2 pellets display well-maintained integrity without cracking with the ramping up to 1500 °C at a heating rate of 8 °C per second. Fracture occurs in both pure and Cr2O3-doped dense nano-sized UO2 pellets. The Cr2O3 doped oxide fuel pellet with a larger grain size (~ 22.2 μm) displays the best performance under LOCA testing due to its highest thermal conductivity under high temperature. FEA calculations suggest a temperature gradient across the fuel pellet during transient testing, resulting in residual stress and cracking, which can be correlated with their thermal-mechanical properties.
High-resolution computed tomographic (HRCT) image series from 413 canid and 18 felid skulls
Authors: Czeibert Kalman , Nagy Gergely , Csörgő Tibor , Donkó Tamás , Petneházy Örs , Csóka Ádám , Garamszegi László Zsolt , Kolm Niclas , Kubinyi Eniko
Published: July 2024

Computed tomography (CT) is a non-invasive, three-dimensional imaging tool used in medical imaging, forensic science, industry and engineering, anthropology, and archaeology. The current study used high-resolution medical CT scanning of 431 animal skulls, including 399 dog skulls from 152 breeds, 14 cat skulls from 9 breeds, 14 skulls from 8 wild canid species (gray wolf, golden jackal, coyote, maned wolf, bush dog, red fox, Fennec fox, bat-eared fox), and 4 skulls from 4 wild felid species (wildcat, leopard, serval, caracal). This comprehensive and unique collection of CT image series of skulls can provide a solid foundation not only for comparative anatomical and evolutionary studies but also for the advancement of veterinary education, virtual surgery planning, and the facilitation of training in sophisticated machine learning methodologies.
On simulations of 3D fractional WBBM model through mathematical and graphical analysis with the assists of fractionality and unrestricted parameters
Authors: Shahen Nur Hasan Mahmud , Foyjonnesa  , Al Amin Md. , Rahman M. M.
Published: July 2024

This study retrieves some novel exact solutions to the family of 3D space–time fractional Wazwaz–Benjamin–Bona–Mahony (WBBM) equations in the context of diverse nonlinear physical phenomena resulting from water wave mechanics. The family of WBBM equations is transformed for this purpose using a space and time fractional transformation into an ordinary differential equation (ODE). The ODE then uses a strong method, namely the Unified Method. Consequently, lump solutions, dark-bright soliton, singular and multiple soliton solutions, and periodic solutions are investigated. The disparities between the current study's conclusions and previously acquired solutions via other approaches are examined. All wave solutions produced are determined to be novel in terms of fractionality, unrestricted parameters, and implemented technique sense. The impact of unrestricted parameters and fractionality on the obtained solutions are visually presented, along with physical explanations. It is observed that the wave portents are varied with the increase of unrestricted parameters as well as fractionality. We dynamically showed that the appropriate transformation and the applied Unified approach more proficient in the study of water wave dynamics and might be used in future researches to clarify the many physical phenomena. The novelty of this work validate that the proposed method seem simple and useful tools for obtaining the solutions in PDEs and it is expected to use in mathematical physics and optical engineering.
Continuous blood pressure prediction system using Conv-LSTM network on hybrid latent features of photoplethysmogram (PPG) and electrocardiogram (ECG) signals
Authors: Kamanditya Bharindra , Fuadah Yunendah Nur , Mahardika T. Nurul Qashri , Lim Ki Moo
Published: July 2024

Continuous blood pressure (BP) monitoring is essential for managing cardiovascular disease. However, existing devices often require expert handling, highlighting the need for alternative methods to simplify the process. Researchers have developed various methods using physiological signals to address this issue. Yet, many of these methods either fall short in accuracy according to the BHS, AAMI, and IEEE standards for BP measurement devices or suffer from low computational efficiency due to the complexity of their models. To solve this problem, we developed a BP prediction system that merges extracted features of PPG and ECG from two pulses of both signals using convolutional and LSTM layers, followed by incorporating the R-to-R interval durations as additional features for predicting systolic (SBP) and diastolic (DBP) blood pressure. Our findings indicate that the prediction accuracies for SBP and DBP were 5.306 ± 7.248 mmHg with a 0.877 correlation coefficient and 3.296 ± 4.764 mmHg with a 0.918 correlation coefficient, respectively. We found that our proposed model achieved a robust performance on the MIMIC III dataset with a minimum architectural design and high-level accuracy compared to existing methods. Thus, our method not only meets the passing category for BHS, AAMI, and IEEE guidelines but also stands out as the most rapidly accurate deep-learning-based BP measurement device currently available.
Mapping reservoir water quality from Sentinel-2 satellite data based on a new approach of weighted averaging: Application of Bayesian maximum entropy
Authors: Nikoo Mohammad Reza , Zamani Mohammad G. , Zadeh Mahshid Mohammad , Al-Rawas Ghazi , Al-Wardy Malik , Gandomi Amir H.
Published: July 2024

In regions like Oman, which are characterized by aridity, enhancing the water quality discharged from reservoirs poses considerable challenges. This predicament is notably pronounced at Wadi Dayqah Dam (WDD), where meeting the demand for ample, superior water downstream proves to be a formidable task. Thus, accurately estimating and mapping water quality indicators (WQIs) is paramount for sustainable planning of inland in the study area. Since traditional procedures to collect water quality data are time-consuming, labor-intensive, and costly, water resources management has shifted from gathering field measurement data to utilizing remote sensing (RS) data. WDD has been threatened by various driving forces in recent years, such as contamination from different sources, sedimentation, nutrient runoff, salinity intrusion, temperature fluctuations, and microbial contamination. Therefore, this study aimed to retrieve and map WQIs, namely dissolved oxygen (DO) and chlorophyll-a (Chl-a) of the Wadi Dayqah Dam (WDD) reservoir from Sentinel-2 (S2) satellite data using a new procedure of weighted averaging, namely Bayesian Maximum Entropy-based Fusion (BMEF). To do so, the outputs of four Machine Learning (ML) algorithms, namely Multilayer Regression (MLR), Random Forest Regression (RFR), Support Vector Regression (SVRs), and XGBoost, were combined using this approach together, considering uncertainty. Water samples from 254 systematic plots were obtained for temperature (T), electrical conductivity (EC), chlorophyll-a (Chl-a), pH, oxidation–reduction potential (ORP), and dissolved oxygen (DO) in WDD. The findings indicated that, throughout both the training and testing phases, the BMEF model outperformed individual machine learning models. Considering Chl-a, as WQI, and R-squared, as evaluation indices, BMEF outperformed MLR, SVR, RFR, and XGBoost by 6%, 9%, 2%, and 7%, respectively. Furthermore, the results were significantly enhanced when the best combination of various spectral bands was considered to estimate specific WQIs instead of using all S2 bands as input variables of the ML algorithms.
Durability analysis of metakaolin recycled concrete under sulphate dry and wet cycle
Authors: Zhong Chuheng , Wang Dongping , Zhang Lijuan , Mao Weiqi , Xing Sijia , Chen Jinhui , Xiao Yuan
Published: July 2024

This study aims to enhance the durability, cost-effectiveness, and sustainability of recycled fine aggregate concrete (RFAC) subjected to the combined effects of wet-dry cycles and sulfate erosion. Dry–wet cycle tests were conducted in RFAC with different admixtures of biotite metakaolin (MK) and 15% fly ash (FA) mix (M) under 5% sulfate erosion environment. The effect of 0%, 30%, 60% and 90% recycled fine aggregate (RFA) replacement of natural fine aggregate on mass loss, cubic compressive strength, relative dynamic modulus test of RFAC, damage modeling and prediction of damage life of concrete were investigated. The results showed that the concrete cubic compressive strength and relative dynamic modulus were optimal for recycled concrete at 15% MK biotite dosing and 60% RFA substitution, and its maximum service life was accurately predicted to be about 578 cycles under 5% sulfate dry–wet cycling using Weibull function model. This study is pioneering in addressing the durability of RFAC under sulfate attack combined with wet-dry cycling, employing a novel approach of incorporating MK and FA into RFAC. The findings highlight the practical application potential for using MK and FA in RFAC to produce durable and sustainable construction materials, particularly in sulfate-exposed environments. This research addresses a critical challenge in the construction industry, providing valuable insights for developing more durable and eco-friendly construction materials and contributing to long-term sustainability goals.
Quantum rectangular MinRank attack on multi-layer UOV signature schemes
Authors: Cho Seong-Min , Seo Seung-Hyun
Published: July 2024

Recent rank-based attacks have reduced the security of Rainbow, which is one of the multi-layer UOV signatures, below the NIST security requirements by speeding up iterative kernel-finding operations using classical mathematics techniques. If quantum algorithms are applied to perform these iterative operations, the rank-based attacks may be more threatening to multi-layer UOV, including Rainbow. In this paper, we propose a quantum rectangular MinRank attack called the Q-rMinRank attack, the first quantum approach to key recovery attacks on multi-layer UOV signatures. Our attack is a general model applicable to multi-layer UOV signature schemes, and in this paper, we provide examples of its application to Rainbow and the Korean TTA standard, HiMQ. We design two quantum oracle circuits to find the kernel in consideration of the depth-width trade-off of quantum circuits. One is to reduce the width of the quantum circuits using qubits as a minimum, and the other is to reduce the depth using parallelization instead of using a lot of qubits. By designing quantum circuits to find kernels with fewer quantum resources and complexity by adding mathematical techniques, we achieve quadratic speedup for the MinRank attack to recover the private keys of multi-layer UOV signatures. We also estimate quantum resources for the designed quantum circuits and analyze quantum complexity based on them. The width-optimized circuit recovers the private keys of Rainbow parameter set V with only 1089 logical qubits. The depth-optimized circuit recovers the private keys of Rainbow parameter set V with a quantum complexity of $$2^{174}$$

2
174

, which is lower than the complexity of $$2^{221}$$

2
221

recovering the secret key of AES-192, which provides the same security level as parameter set III.