bluuebunny/crossref_metadata_2025 huggingface dataset:
AN INTERVENTION TO ENHANCE OCCUPATIONAL PERFORMANCE OF CHILDREN WITH OBSTETRICAL BRACHIAL PLEXUS PALSY
Authors: ATASAVUN UYSAL Songul , TONGA Eda
Published: September 2021

Purpose: Children with obstetric brachial plexus palsy (OBPP) have problems with activity and participation, even if they are operated. The study aimed to investigate the intervention's effects to increase the occupational performance (OP) of children with OBPP.
Methods: Twenty-nine children with OBPP, aged 4-7 years, participated in this study. The intervention group consisted of six girls and 12 boys, and a control group was composed of eight girls and three boys. The Canadian Occupational Performance Measure (COPM) determined children's OP. The Pediatric Evaluation of Disability Inventory (PEDI) was used to evaluate functional capability. All subjects continued their traditional physiotherapy program of 45 minutes every two days. The intervention group participated in an intervention program, consisting of the children and their families' needs, expectations, and therapists' assessment, about OP 40 minutes per day three days per week for three months.
Results: The PEDI self-care, mobility, social function, and total scores and COPM-performance and COPM-satisfaction scores significantly increased in the intervention group (p<0.05). PEDI mobility, social function, and total scores significantly improved in the control group (p<0.05, Table 1). There was a significant difference in PEDI self-care (p=0.020) and total scores (p=0.009) between the two groups. There was no significant difference in COPM-performance and COPM-satisfaction scores in the control group (p>0.05).
Conclusions: The present study is the first study on OP intervention in children with OBPP. The present study suggests intervening to enhance OP and via assessing using COPM in the children with OBPP.
Recent Trends on the Development of Machine Learning Approaches
for the Prediction of Lysine Acetylation Sites
Authors: Basith Shaherin , Chang Hye Jin , Nithiyanandam Saraswathy , Shin Tae Hwan , Manavalan Balachandran , Lee Gwang
Published: September 2021

:

Acetylation on lysine residues is considered one of the most potent protein
post-translational modifications, owing to its crucial role in cellular metabolism and regulatory
processes. Recent advances in experimental techniques have unraveled several lysine
acetylation substrates and sites. However, owing to its cost-ineffectiveness, cumbersome
process, time-consumption, and labor-intensiveness, several efforts have been
geared towards the development of computational tools. In particular, machine learning
(ML)-based approaches hold great promise in the rapid discovery of lysine acetylation
modification sites, which could be witnessed by the growing number of prediction tools.
Recently, several ML methods have been developed for the prediction of lysine acetylation
sites, owing to their time- and cost-effectiveness. In this review, we present a complete
survey of the state-of-the-art ML predictors for lysine acetylation. We discuss a variety
of key aspects for developing a successful predictor, including operating ML algorithms,
feature selection methods, validation techniques, and software utility. Initially, we
review lysine acetylation site databases, current ML approaches, working principles, and
their performances. Lastly, we discuss the shortcomings and future directions of ML approaches
in the prediction of lysine acetylation sites. This review may act as a useful
guide for the experimentalists in choosing the right ML tool for their research. Moreover,
it may help bioinformaticians in the development of more accurate and advanced MLbased
predictors in protein research.
Recent Updates on Pyrazoline Derivatives as Promising Candidates for Neuropsychiatric and Neurodegenerative Disorders
Authors: Rangarajan T. M. , Mathew Bijo
Published: September 2021

Pyrazolines are five-membered heterocyclic compounds containing two nitrogen atoms
that represent a privileged scaffold for various bioactive compounds with diverse pharmacological
activities. Chalcones and hydrazine derivatives are excellent precursors for pyrazolines, which provide
easy access for fabricating the pyrazoline ring at N1, C3 and C5 positions that give rise to a wide
range of pyrazoline designs. In addition, this method institutes a new asymmetric center at C5 position
and extent of the conjugation between phenyl group at C3 position to N1 that could greatly enhance
the physicochemical and pharmacological properties towards the target enzymes and hence
they are reported to have a wide spectrum of biological activities such as anti-cancer, antiinflammatory,
etc. Most importantly, they have remarkable effects on the central nervous system
(CNS). Several reports show that the pyrazoline derivatives have a significant inhibitory effect towards
the monoamine oxidase enzymes (MAOs), which are known to be responsible for neurodegenerative
disorders. These enzymes have two isoforms, namely MAO-A and MAO-B which are, in
particular, responsible for psychiatric and neurological disorders, respectively. Chalcones are generally
potential and more selective inhibitors towards MAO-B isoform whereas pyrazolines derived from
chalcones mostly turned into selective inhibitors of MAO-A isoform may be due to the presence of
two nitrogen heteroatoms. Therefore, these two derivatives have received much attention from medicinal
chemists as they could solve entire CNS-related issues; however pyrazolines have not been studied
as much as chalcones. Our group already documented the importance of pyrazolines towards
MAO-A inhibition in 2013. With their growing importance, several studies on pyrazolines have constantly
been reported for their MAO inhibitions. Therefore, in this review, we report up-to-date developments
(after 2014) on pyrazolines as potential MAO inhibitors.
Maslinic Acid Inhibits Cervical Intraepithelial Neoplasia by Suppressing Interleukin-
6 and Enhancing Apoptosis in a Mouse Model
Authors: Chen Jiuwei , Wang Lin
Published: September 2021

Background:

Cervical intraepithelial neoplasia (CIN) directly precedes cervical cancer, and elevated proinflammatory
cytokine interleukins (IL)-6 is implicated in CIN.

Objective:

As maslinic acid exhibits anti-IL-6 property, the present study sought to determine the effect of maslinic
acid on CIN in vitro and in vivo using cell cultures and mouse CIN models, respectively.

Methods:

The dose-effect of maslinic acid on HeLa cells, a human cervical cancer cell line, was first evaluated, including
cytotoxicity, IL-6 secretion, IL-6 receptor (IL-6R) expression, proliferation potential and apoptosis status. A mouse
model of CIN was also established, which was then subjected to increasing doses of maslinic acid treatment, followed
by assessment of serum IL-6 level, cervical expression of IL-6R, and the proliferation potential and apoptosis of cervical
tissues.

Results:

Maslinic acid dose-dependently inhibited cell growth and proliferation potential, reduced IL-6 secretion, cervical
expression of IL-6R and induced apoptosis of HeLa cells in vitro. In the CIN mouse model, serum IL-6 level and
cervical expression of IL-6R were elevated, which could be repressed by maslinic acid administration dosedependently.
Additionally, maslinic acid treatment in the CIN mice could also restore the otherwise increased proliferation
potential and reduced apoptosis in the cervical tissues.

Conclusion:

Maslinic acid exhibits potent anti-IL-6 property in the CIN mouse model, and alleviates the diseaserelated
abnormality in proliferation potential and apoptosis state of the cervical tissue cells, demonstrating its usefulness
as a promising agent in treating CIN.
Targeted Delivery of Montelukast for the Treatment of Alzheimer’s
Disease
Authors: Datusalia Ashok K. , Singh Gurpreet , Yadav Nikita , Gaun Sachin , Manik Moumita , Singh Rakesh K.
Published: September 2021

:

Alzheimer’s Disease (AD) is one of the most common neurodegenerative diseases,
which affects millions of people worldwide. Accumulation of amyloid-β plaques and hyperphosphorylated
neurofibrillary tangles are the key mechanisms involved in the etiopathogenesis of AD,
characterized by memory loss and behavioural changes. Effective therapies targeting AD pathogenesis
are limited, making it the largest unmet clinical need. Unfortunately, the available drugs provide
symptomatic relief and primary care, with no substantial impact on the disease pathology.
However, in recent years researchers are working hard on several potential therapeutic targets to
combat disease pathogenesis, and few drugs have also reached clinical trials. In addition, drugs are
being repurposed both in the preclinical and clinical studies for the treatment of AD. For instance,
montelukast is the most commonly used leukotriene receptor antagonist for treating asthma and seasonal
allergy. Its leukotriene antagonistic action can also be beneficial for the reduction of detrimental
effects of leukotriene against neuro-inflammation, a hallmark feature of AD. The available
marketed formulations of montelukast present challenges such as poor bioavailability and reduced
uptake, reflecting the lack of effectiveness of its desired action in the CNS. While on the other side,
targeted drug delivery is a satisfactory approach to surpass the challenges associated with the therapeutic
agents. This review will discuss the enhancement of montelukast treatment efficacy and its
access to CNS by using new approaches like nano-formulation, nasal gel, solid lipid formulation,
nano-structure lipid carrier (NSLC), highlighting lessons learned to target AD pathologies and hurdles
that persist.
Liquid Chromatographic Analysis of Methotrexate and Minocycline-relevance to the Determination in Plasma/Nanoparticulate Formulations
Authors: Janakiraman Kumar , Krishnaswami Venkateshwaran , Sethuraman Vaidevi , Rajendran Vijaya , Kandasamy Ruckmani
Published: September 2021

Aim:

To develop RP-HPLC method for the simultaneous estimation of methotrexate
(MTX) and minocycline (MNC).

Background:

Different HPLC methods were reported for the estimation of MTX/MNC individually,
but there is no report for the simultaneous estimation of both MTX and MNC in a simple
method.

Objective:

The objective of the developed method is to utilize the method for the estimation of
MTX/MNC in different pharmaceutical formulations and in biological fluids

Methods:

An HPLC method for the estimation of Methotrexate (MTX) and Minocycline (MNC)
relevance to the evaluation of nanoparticulate formulations has been developed and validated. Chromatographic
estimation was achieved using the mobile phase composition of sodium acetate buffer
and acetonitrile (70:30% v/v) at pH 4.0 at a flow rate of 0.2 mL/min at 307 nm.

Results:

The calibration curve for MTX and MNC was found to be linear at nanogram (5 to 25
ng.mL-1) and microgram (5 to 25 μg.mL-1) levels at correlation coefficient range of 0.98 to 0.99
for both MTX/MNC. The lower limit of detection and limit of quantification were found to be
0.026 ng.mL-1 and 0.079 ng.mL-1 for MTX and MNC, respectively. The percentage relative standard
deviation for validation parameters of both drugs was found to be less than 6.5%. The amount
of MTX and MNC present within the nanoparticles was found to be MTX (0.84 mg/mL) and MNC
(0.61 mg/mL). The in vitro release showed an immediate release pattern for MTX (64.95±2.08%)
and MNC (90.90±1.78%) within 12 h.

Conclusion:

The developed analytical method for the simultaneous estimation of MTX and MNC
was found to be simple, affordable, dynamic, low cost, rapid and easy to perform with good repeatability.
This method is also time consuming, since the peaks were obtained within a moderate
analysis time.
Асимптотически запрещенные по спину квазимолекулярные радиационные переходы
Authors: Девдариани А.З.
Published: September 2021

В обзоре обсуждены теоретические работы по радиационным переходам, которые инициируются тепловыми столкновениями атомов групп 2А, 12 Таблицы Менделеева с атомами инертных газов, а также несимметричными столкновениями атомов инертных газов и приводят либо к распаду, либо к заселению нижнего метастабильного состояния 3P2. Обсуждение проводится в рамках аналитических подходов, основанных на использовании псевдопотенциала Ферми и полуэмпирического метода. Представлены результаты вычислений констант скоростей, коэффициентов поглощения, времен жизни колебательных состояний, формы спектров. Ключевые слова: оптическая спектроскопия столкновения, взаимодействие квазимолекулярных состояний, псевдопотенциал Ферми, полуэмпирическая процедура восстановления термов.
Оптические и электрохромные свойства тонких пленок амбиполяных полиимидов с пендантными группами на основе производных тоиксантенона
Authors: Кручинин В.Н. , Одинцов Д.С. , Шундрин Л.А. , Шундрина И.К. , Рыхлицкий С.В. , Спесивцев Е.В. , Гриценко В.А.
Published: September 2021

Методами спектральной эллипсометрии, спектрофотометрии и спектроэлектрохимии исследованы оптические и электрохромные свойства тонких пленок, полученных методом центрифугирования из растворов, содержащих амбиполярные полиимиды с пендантными группами на основе 9H-тиоксантен-9-она и его S-диоксидного производного. Показано, что спектральные зависимости показателя преломления и коэффициента поглощения, а также электрохромные свойства тонких пленок полиимидов в условиях электрохимического восстановления и окисления сильно зависят от типа пендантной группы. На основании оценок ширины запрещенной зоны сделан вывод о возможном перспективном использовании тонких пленок полиимидов в качестве рабочих слоев в мемристорах нового типа. Ключевые слова: мемристоры, диэлектрические пленки, амбиполярные полиимиды, эллипсометрия, электрохромизм.
Высокоэффективная генерация сжатых состояний света на основе мод Лагерра-Гаусса в резонаторе
Authors: Башмакова Е.Н. , Вашукевич Е.А. , Голубева Т.Ю. , Голубев Ю.М.
Published: September 2021

Эффективная генерация сжатых состояний света представляется важной практической проблемой для различных квантово-оптических и информационных приложений. В данной работе исследована возможность повышения эффективности генерации состояний на основе мод Лагерра-Гаусса в процессе параметрического преобразования света за счет оптимального выбора резонаторной конфигурации. Пользуясь аппаратом уравнений Гейзенберга-Ланжевена для собственных мод системы, мы проанализировали влияние геометрических параметров пучка накачки, а также холостого и сигнального пучков на генерацию сжатых состояний. Расчет для конечного числа мод показал, что наибольший теоретически возможный уровень сжатия в рассматриваемой системе составляет 15.85 dB. Ключевые слова:
Изменение оптических свойств оксида титана при кристаллизации
Authors: Булярский С.В. , Коива Д.А. , Гусаров Г.Г. , Светухин В.В.
Published: September 2021

Crystallization of amorphous titanium oxide films synthesized by magnetron sputtering was carried out at temperatures of 700, 800, and 900 oC in an oxygen atmosphere. The refractive index of the films increases during crystallization with a time constant that depends on temperature, which made it possible to determine the activation energy of the crystallization process on the order of 0.6 eV. The growth kinetics model for the titanium oxide nanocrystals, which is used in this work, showed that the indicated activation energy corresponds to the diffusion energy of oxygen vacancies. This process is decisive for the growth of titanium oxide nanocrystals upon annealing in an oxygen atmosphere. The study of photoluminescence has shown that crystallization leads to a change in the ratio of intensities of different emission bands. The bands that are associated with the oxygen vacancy are extinguished. A decrease in the concentration of these vacancies in films leads to an increase in their resistance and stabilization of the films in time.
Health Impacts and Characteristics of Deprescribing Interventions in Older Adults: Protocol for a Systematic Review and Meta-analysis
Authors: Tremblay Zoë , Mumbere David , Laurin Danielle , Sirois Caroline , Furrer Daniela , Poisblaud Lise , Carmichael Pierre-Hugues , Farrell Barbara , Tourigny André , Giguere Anik , Vedel Isabelle , Morais José , Kröger Edeltraut
Published: September 2021

Background

Deprescribing, a relatively recent concept, has been proposed as a promising solution to the growing issues of polypharmacy and use of medications of questionable benefit among older adults. However, little is known about the health outcomes of deprescribing interventions.

Objective

This paper presents the protocol of a study that aims to contribute to the knowledge on deprescribing by addressing two specific objectives: (1) describe the impact of deprescribing in adults ≥60 years on health outcomes or quality of life; and (2) determine the characteristics of effective interventions in deprescribing.

Methods

Primary studies targeting three concepts (older adults, deprescribing, and health or quality of life outcomes) will be included in the review. The search will be performed using key international databases (MEDLINE, EMBASE, CINAHL, Ageline, PsycInfo), and a special effort will be made to identify gray literature. Two reviewers will independently screen the articles, extract the information, and evaluate the quality of the selected studies. If methodologically feasible, meta-analyses will be performed for groups of intervention studies reporting on deprescribing interventions for similar medications, used for similar or identical indications, and reporting on similar outcomes (eg, benzodiazepines used against insomnia and studies reporting on quality of sleep or quality of life). Alternatively, the results will be presented in bottom-line statements (objective 1) and a matrix outlining effective interventions (objective 2).

Results

The knowledge synthesis may be limited by the availability of high-quality clinical trials on deprescribing and their outcomes in older adults. Additionally, analyses will likely be affected by studies on the deprescribing of different types of molecules within the same indication (eg, different pharmacological classes and medications to treat hypertension) and different measures of health and quality of life outcomes for the same indication. Nevertheless, we expect the review to identify which deprescribing interventions lead to improved health outcomes among seniors and which of their characteristics contribute to these outcomes.

Conclusions

This systematic review will contribute to a better understanding of the health outcomes of deprescribing interventions among seniors.

Trial Registration

PROSPERO International Prospective Register of Systematic Reviews CRD42015020866; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42015020866

International Registered Report Identifier (IRRID)

PRR1-10.2196/25200
Detecting Tonic-Clonic Seizures in Multimodal Biosignal Data From Wearables: Methodology Design and Validation
Authors: Böttcher Sebastian , Bruno Elisa , Manyakov Nikolay V , Epitashvili Nino , Claes Kasper , Glasstetter Martin , Thorpe Sarah , Lees Simon , Dümpelmann Matthias , Van Laerhoven Kristof , Richardson Mark P , Schulze-Bonhage Andreas ,   The RADAR-CNS Consortium
Published: September 2021

Background

Video electroencephalography recordings, routinely used in epilepsy monitoring units, are the gold standard for monitoring epileptic seizures. However, monitoring is also needed in the day-to-day lives of people with epilepsy, where video electroencephalography is not feasible. Wearables could fill this gap by providing patients with an accurate log of their seizures.

Objective

Although there are already systems available that provide promising results for the detection of tonic-clonic seizures (TCSs), research in this area is often limited to detection from 1 biosignal modality or only during the night when the patient is in bed. The aim of this study is to provide evidence that supervised machine learning can detect TCSs from multimodal data in a new data set during daytime and nighttime.

Methods

An extensive data set of biosignals from a multimodal watch worn by people with epilepsy was recorded during their stay in the epilepsy monitoring unit at 2 European clinical sites. From a larger data set of 243 enrolled participants, those who had data recorded during TCSs were selected, amounting to 10 participants with 21 TCSs. Accelerometry and electrodermal activity recorded by the wearable device were used for analysis, and seizure manifestation was annotated in detail by clinical experts. Ten accelerometry and 3 electrodermal activity features were calculated for sliding windows of variable size across the data. A gradient tree boosting algorithm was used for seizure detection, and the optimal parameter combination was determined in a leave-one-participant-out cross-validation on a training set of 10 seizures from 8 participants. The model was then evaluated on an out-of-sample test set of 11 seizures from the remaining 2 participants. To assess specificity, we additionally analyzed data from up to 29 participants without TCSs during the model evaluation.

Results

In the leave-one-participant-out cross-validation, the model optimized for sensitivity could detect all 10 seizures with a false alarm rate of 0.46 per day in 17.3 days of data. In a test set of 11 out-of-sample TCSs, amounting to 8.3 days of data, the model could detect 10 seizures and produced no false positives. Increasing the test set to include data from 28 more participants without additional TCSs resulted in a false alarm rate of 0.19 per day in 78 days of wearable data.

Conclusions

We show that a gradient tree boosting machine can robustly detect TCSs from multimodal wearable data in an original data set and that even with very limited training data, supervised machine learning can achieve a high sensitivity and low false-positive rate. This methodology may offer a promising way to approach wearable-based nonconvulsive seizure detection.
Optimizing Coaching During Web-Based Relationship Education for Low-Income Couples: Protocol for Precision Medicine Research
Authors: Hatch S Gabe , Lobaina Diana , Doss Brian D
Published: September 2021

Background

In-person relationship education classes funded by the federal government tend to experience relatively high attrition rates and have only a limited effect on relationships. In contrast, low-income couples tend to report meaningful gains from web-based relationship education when provided with individualized coach contact. However, little is known about the method and intensity of practitioner contact that a couple requires to complete the web-based program and receive the intended benefit.

Objective

The aim of this study is to use within-group models to create an algorithm to assign future couples to different programs and levels of coach contact, identify the most powerful predictors of treatment adherence and gains in relationship satisfaction within 3 different levels of coaching, and examine the most powerful predictors of treatment adherence and gains in relationship satisfaction among the 3 levels of coach contact.

Methods

To accomplish these goals, this project intends to use data from a web-based Sequential Multiple Assignment Randomized Trial of the OurRelationship and web-based Prevention and Relationship Enhancement programs, in which the method and type of coach contact were randomly varied across 1248 couples (2496 individuals), with the hope of advancing theory in this area and generating accurate predictions. This study was funded by the US Department of Health and Human Services, Administration for Children and Families (grant number 90PD0309).

Results

Data collection from the Sequential Multiple Assignment Randomized Trial of the OurRelationship and web-based Prevention and Relationship Enhancement Program was completed in October of 2020.

Conclusions

Some of the direct benefits of this study include benefits to social services program administrators, tailoring of more effective relationship education, and effective delivery of evidence- and web-based relationship health interventions.

International Registered Report Identifier (IRRID)

DERR1-10.2196/33047
An Advanced Nursing Directive for Children With Suspected Appendicitis: Protocol for a Quality Improvement Feasibility Study
Authors: Chaudhari Hanu , Schneeweiss Michelle , Rebinsky Reid , Rullo Enrico , Eltorki Mohamed
Published: September 2021

Background

Pediatric appendicitis accounts for an estimated 7% to 10% of abdominal pain cases in the emergency department (ED). The diagnosis is time-consuming, and the investigative process depends on physician assessment, resulting in delays in diagnosis and therapeutic management. The utility of an advanced nursing directive (AND) to expedite this process is unclear and needs further exploration.

Objective

This study aims to describe key components of ED flow in patients with suspected appendicitis seen at a pediatric ED and pilot a directive that allows ED nurses to perform an order set that includes blood work, urine tests, analgesics, fluids, and an abdominal-pelvis ultrasound prior to physician assessment.

Methods

This study involves conducting a retrospective chart review alongside a quality improvement initiative to compare key ED flow metrics before and after AND implementation. Primary outcome measures include median time from ED triage assessment to ultrasound completion, analgesia administration, blood work results, and time to disposition (consult or discharge), alongside other key ED flow metrics for suspected appendicitis. Secondary outcomes will involve patient and caretaker satisfaction surveys. Descriptive statistics will be used to summarize the data. For differences in proportions, a chi-square test will be used. The Student t test will be used for continuous variables. A variable-controlled run chart will be performed to assess impact on ED flow metrics. Patient and family satisfaction surveys are administered immediately after the directive encounter and 7 days afterward.

Results

There are currently 3900 patients who have been screened, 344 patients who have been enrolled, and 90 patients who have received the medical directive since implementation in June 2020. Interim results on reduction of time to diagnostic and therapeutic ED flow parameters and satisfaction surveys are expected to be published in February 2022. The final study endpoint will be in June 2022.

Conclusions

This study proposes a novel protocol for improving the diagnosis and treatment of suspected pediatric appendicitis through implementation of an evidence-based AND. This model may provide a standardized, international pathway for management of common pediatric and adult emergencies.

International Registered Report Identifier (IRRID)

RR1-10.2196/33158
Проблематика корректной проверки пригодности и оценки экономической эффективности ВЭЖХ-методик
Authors: Сычев К.С. , Окунская Е.А.
Published: September 2021

В статье формулируется набор характеристик ВЭЖХ-методики, необходимых для полного описания ее пользовательских свой­ств. Показано, что стандартная общепринятая процедура валидации затрагивает только три из десяти основных характеристик качества ВЭЖХ-методики. Обсуждаются характеристики качества ВЭЖХ-методики, не входящие в стандартный набор для валидации. Приведена классификация характеристик качества ВЭЖХ-методики, предложено разделить их на три группы согласно влиянию на пригодность и экономическую эффективность.
Effectiveness of the quadriceps strengthening exercise on pain and functional ability of the women with Osteoarthritis (OA)
Authors:   Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia. E-mail: aqureshi@kku.edu.sa, Mobile: +966- 534539759. ORCID ID: 0000-0002-0577-6700, Ahmed Qureshi Absar , Alshahrani Shadia Hamoud ,   College of Nursing, Mahalah Branch for Girls, King Khalid University, Asir Province, Saudi Arabia. E-mail: shalshrani@kku.edu.sa, Mobile. +966 500658205. ORCID ID: 0000-0002-1428-787X, Paulsamy Premalatha ,   College of Nursing, Mahalah Branch for Girls, King Khalid University, Asir Province, Saudi Arabia Email: pponnuthai@kku.edu.sa. Mobile: +966-563595142. ORCID ID: 0000-0001-5117-480X, Venkatesan Krishnaraju ,   Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Asir Province, Saudi Arabia. Email: kvenkatesan@kku.edu.sa. Mobile: 6+966-504839653. ORCID ID: 0000-0003-2853-5907, Sethuraj Pranave ,   Software Engineer, Vee Care College of Nursing Chennai, E-mail: spranave98@gmail.com., Mobile: +91 7598354736, ORCID ID: 0000-0002-7609-3990
Published: September 2021

A Quasi experimental design was adopted for this study to find out the effectiveness of quadriceps strengthening exercise program on pain and functional ability of women with knee osteoarthritis (OA). Fifty women with OA were selected in which first 25 women were enrolled in the control group and second 25 women were allotted in the exercise group. Assessments were performed at baseline and at 8 weeks. The functional ability was assessed using the Timed Up and Go (TUG) test and Numerical Rating Scale (NRS) was used to assess the pain level .For the exercise group, quadriceps strengthening exercises were taught and asked the patients to follow the exercise schedule for 8 weeks. The study results show that the pain and functional abilty scores were improved in the exercise group and the difference was statistically significant (p<0.001). The study concluded that a simple quadriceps strengthening exercise programme can significantly improve self reported knee pain and functional ability among women with Knee osteoarthritis. Keywords: Osteoarthritis, Pain, Functional Ability, Exercise, Quadriceps strengthening, Timed Up and Go (TUG) test, Numerical Rating Scale (NRS)
El Portal Educativo META de Paraguay Educa: su desarrollo y propuesta de valor
Authors: Rosenberger Sascha
Published: September 2021

El Portal Educativo META de Paraguay Educa se desarrolla para proveer a Paraguay de un Portal Educativo de alcance nacional, en apoyo a los planes nacionales de desarrollo, pero con base en estándares internacionales. Se resaltan dos puntos clave que hacen innovador al Portal: el énfasis en su cocreación y el empleo de recursos educativos y elementos tecnológicos libres que garantizan la oportunidad de cocreación. En cuanto a su accesibilidad, el Portal es completamente gratuito, y se ha negociado con empresas de telecomunicación el tráfico sin costo al Portal para facilitar el acceso de toda la población.
Reseña del libro Metodi digitale per l’insegnamento classico e umanistico
Authors: Priani Saisó Ernesto
Published: September 2021

El libro de Paolo Monella Metodi digitale per l’insegnamento classico e umanistico es una reflexión crítica de carácter metodológico sobre instrumentos y técnicas digitales para la enseñanza en el nivel de bachillerato y universitario, con énfasis en la didáctica de la lengua, la literatura y la cultura clásica.
Para leer más y mejor CommonLit es una opción
Authors: Jara Arancibia Gema
Published: September 2021

La pandemia ha sido un parteaguas en el uso de herramientas digitales para el aprendizaje. Por este motivo, CommonLit se ha convertido en una gran ayuda para practicar la lectura como mecanismo de comunicación que permite la apropiación de conceptos de diversas materias y la práctica recurrente de habilidades lectoras a través de la lectura, la escritura, la argumentación -a través del diálogo- y la escucha activa. En este artículo aprenderás sobre CommonLit como plataforma de comprensión lectora en español e inglés, reconocida mundialmente como una herramienta didáctica para practicar habilidades de lectura, utilizada por más de 20 millones de profesores, bibliotecarios, estudiantes y padres.
El diseño de contenido, una visión desde la perspectiva de los expertos en contenido
Authors: Panales Guerrero Carlos Arturo , Ramírez Juárez Oliverio , Ramírez Torres Fátima
Published: September 2021

La educación virtual se potenció por la pandemia que vivimos en México y el mundo. Hoy en día las instituciones educativas presenciales de todos los niveles educativos utilizan diversos recursos y herramientas tecnológicas, típicas de la educación a distancia para continuar con sus procesos de enseñanza-aprendizaje. Sin embargo, en educación a distancia, además de utilizar herramientas y plataformas, existe todo un proceso sistematizado para que el estudiantado de esta modalidad lleve a cabo su proceso de aprendizaje. La esencia de este proceso es el diseño de contenidos académicos realizado por un experto en contenidos. En entrevista, expertos de las Instituciones que conforman la RED de Bachilleratos Universitarios Públicos a Distancia comparten los aspectos que debe considerar un diseñador de contenido para incidir en el aprendizaje del estudiantado, las competencias con las que debe contar, el trabajo colaborativo y multidisciplinario con otros expertos y finalmente qué consideraciones deben existir para evaluar la calidad de un curso virtual.
Evaluación de recursos didácticos digitales del nivel medio superior en el Instituto Politécnico Nacional (IPN)
Authors: Arjona Gordillo Martha , Blando Chávez Macarena , Carreto Arellano Chadwick
Published: September 2021

El desarrollo de recursos didácticos digitales en el nivel medio superior del Instituto Politécnico Nacional (IPN) es una actividad que los docentes realizan con regularidad, así como su implementación en los programas presenciales y a distancia. El IPN, a través del proceso de evaluación de esos recursos, busca motivar e incentivar los esfuerzos de esos docentes entusiastas y también sumar a otros docentes que aún no realizan estas actividades. La Dirección de Educación Virtual, como área encargada de estos procesos, canaliza esfuerzos para brindar a dichos docentes un proceso de evaluación con criterios claros. Está precedido de un acompañamiento cercano con miras a la mejora: se trata de un proceso de evaluación no punitivo, sino constructivo para hacer conciencia de que los recursos didácticos digitales no deben tener como principal razón de ser ganar puntos para promoción, sino subsanar necesidades apremiantes en los procesos de enseñanza-aprendizaje de cada materia.
Experimental Investigation of Using Recycled Plastic Aggregates in Concrete with OPC 53 Grade
Authors: Krishnaveni Chevvu
Published: September 2021

Abstract: Plastic pollution is one of the greatest causes of global warming. Disposal of large quantity of plastic waste products causes environmental & health issues .This report will discuss a solution to plastic pollution by conducting to recycle the plastic and reuse in concrete, so the waste plastic is recycled into plastic aggregates. This paper aims to enhance the concrete mechanical properties by replacement of natural coarse aggregate with recycled plastic aggregates and by adding polypropylene fibers in combination with high performance cement as a partial replacement of cement. This both combinations in concrete gave excellent values of compressive strength and tensile strength. Replacement of coarse aggregate weight by 5%, 10%, 15%, 20%, 25% of recycled plastics and for each replacement percentages polypropylene fibres of 0.5%, 1.0%, 1.5%, 2.0% with partial replacement of cement were conducted. In literature reported that the addition of recycled plastic causes the reduction of strength due to poor bonding between concrete and plastics, to overcome this problem the addition of polypropylene fibres which has a good bonding property will improve the concrete strength were added. Result shows that 15% replacement of natural aggregates with plastic aggregate achieves the maximum strength of concrete. Keywords: Re-cycled plastic aggregates, polypropylene fibres, high performance cement, compressive strength, split tensile strength.
Gold price prediction using Convolutional Neural Network-Long Short-Term Memory (CNN-LSTM)
Authors: Krisna Gita Santika I Wayan , Sa'adah Siti , Yunanto Prasti Eko
Published: September 2021

Gold has an important role in worldwide economics. Gold is not only used in jewelry but also can be a good deal for investment however several factors can affect the fluctuation in gold which can make the risk of investing in gold is bigger for many people. Therefore, is very important to predict the gold price for people who invest in gold in order to help reduce the investment risk. This study will implement a hybrid method from Convolutional Neural Network (CNN) and Long Short-Term Memory (LSTM). CNN can extract useful knowledge and learn the internal representation of time-series data, and LSTM networks will identify short-term and long-term dependencies effectively. This research will use daily time frame data and weekly time frame data. This research also tried some experiments to find the best hyperparameters of batch size and epochs in ratio data 60:40 and 80:20. The best result obtained in the daily time of ratio data 60:40 with RMSE 13.67953 and MAE 9,40998, while in ratio data 80:20 has RMSE 15,53199 and MAE 12,78120. In weekly time has obtained the RMSE 38,01949 and MAE 28,32035 for ratio data 60:40 while in ratio data 80:20 the result was RMSE 32,61283 and MAE 22,74638. Those results shows that CNN-LSTM model can predict the trend of daily time frame gold price.
Development of Digital Ventilator with Internet of Things for Preparation of the Next Outbreak in Indonesia
Authors: Adiputra Dimas , Hafidz Isa , Montolalu Billy , Rasyid Fauzan
Published: September 2021

The emergency of the healthcare device unit, such as a ventilator, has been experienced during the COVID-19 pandemic in 2020. Therefore, ventilator usage is not hard suggested anymore for COVID-19 patients compared to the outbreak beginning. Despite that, it is still essential to have the ventilator ready, if possible, in each house, for the upcoming respiratory syndrome outbreak. Therefore, in this paper, a digital ventilator development is presented. The digital ventilator is comprised of three main parts, such as respiration mechanism (I), controller Internet of Things (IoT) module (II), and website application (III). The developed digital ventilator has been tested by comparing the measurement of respiratory data between the developed digital ventilator and gas flow analyzer. Results show that the respiratory data, such as Pressure Peak (PPeak), Positive End Respiratory Pressure (PEEP), Inspiratory Expiratory Ratio (IE Ratio), Breath per Minute (BPM), and Tidal Volume can be monitored and controlled both directly and online via website application consistently (standard deviation around 10%) with PPeak absolute error of 1.35 mbar, the PEEP absolute error of 0.16 mbar. Furthermore, the average time response of the digital ventilator to the input command from the website application is 0.23 s. Therefore, it is safe to assume that the doctor can use the website application to control the digital ventilator remotely.
Co-Infección por Cryptococcus neoformans en paciente trasplantado renal con COVID-19. Reporte de caso.
Authors: Torrez Serrano Rodolfo Eduardo , Rosselli San Martin Carlos , Olivares  Algarin Orlando , Agudelo Gonzalez Stefany , Carrillo Ayerbe María Paula , Coral Zuñiga Victoria Elena
Published: September 2021

La infección por el síndrome respiratorio agudo severo por coronavirus 2 (SARS-CoV-2), causante de la enfermedad COVID-19, representa una de las emergencias sanitarias más deletéreas de las últimas dos décadas; de la que aún existen innumerables incógnitas acerca del curso y manejo de presentaciones atípicas. Por lo anterior, resulta importante publicar casos clínicos de interés en población especial como lo son los pacientes receptores de trasplante renal quienes pueden tener un mayor riesgo de contraer la enfermedad por el estado de inmunosupresión y por el contacto frecuente con el sistema de atención médica. 

La coinfección con otros virus respiratorios no es infrecuente en población trasplantada con COVID-19, y la asociación con gérmenes oportunistas como Micobacterias, Citomegalovirus, Pneumocystis jirovecii y hongos, tal como el Cryptococcus neoformans es desconocida, pero es posible que dicha asociación podría empeorar la severidad del compromiso sistémico y pulmonar.

Se presenta el caso de un hombre de 45 años que ingresó al servicio de urgencias del Hospital de San José, con antecedente de trasplante renal de donante cadavérico, el presentó SINDROME DE DIFICULTAD RSEPIRATORIA AGUDA (SDRA) y falla ventilatoria por infección por SARS-CoV-2, además se confirmó infección sistémica por Cryptococcus neoformans sin compromiso del sistema nervioso central.  Se inició manejo con ventilación mecánica invasiva, glucocorticoide, anfotericina B liposomal y fallece a los 12 días de su ingreso.
System and activity approach to learning artificial intelligence in basic school
Authors: Levchenko Irina V. , Sadykova Albina R.
Published: September 2021

Problem and goal. The problem of insufficient substantive and methodological support for the training of basic school pupils in the field of artificial intelligence (AI) is considered. The aim is to identify the features of the application of the system-activity approach to teaching basic school pupils in the field of artificial intelligence, to describe the principles of teaching school pupils the basics of artificial intelligence and the conditions for their implementation, to highlight the types of school pupils activities in the context of the system-activity approach. Methodology. A set of methods was used: analysis of regulatory documents that determine the priority tasks of our country; analysis of research and scientific and methodological publications in the field of teaching AI for basic school pupils in the domestic and foreign education system; reflection of the content of the knowledge gained; identification of methodological approaches; search for principles, conditions and opportunities for teaching elements of AI to basic school pupils; local pedagogical experiment. Results. A comparative analysis of the methodological experience of predecessor teachers made it possible to identify the possibility and effectiveness of the application of the system-activity approach to teaching basic school pupils in the field of AI. The revealed approach made it possible to determine the fundamental principles of teaching the elements of artificial intelligence, the conditions for their implementation, as well as the most appropriate types of activities for basic school pupils. Conclusion. Today AI technologies are actively developing information technologies and possession of them has a positive effect on the level of information culture of a school pupils, which, in accordance with the requirements of the information society, must be formed, at least, in basic school. The results of the study made it possible to substantiate the possibility and expediency of applying the system-activity approach to teaching the elements of artificial intelligence to basic school pupils, starting from grade 5.
O riso como agente do thaumaston no teatro antigo
Authors: De Sena André
Published: September 2021

O maravilhoso (thaumaston) foi discutido por Aristóteles em Poética, e nessa obra ele está associado ao gênero épico e à tragédia, com características específicas em cada um deles, mas não se fala nessa categoria em relação à comédia. Mas neste artigo intentamos revelar alguns exemplos que contradizem isso, artísticos e teóricos, mostrando que a metalinguagem e o metateatro irônicos, fundamentais para uma ulterior noção do que constituiria o jogo ficcional – incluindo aí a presença do maravilhoso –, já são operados pelo riso nos palcos cômicos da Antiguidade. Através de referências a obras do teatro antigo que ainda podem ser lidas, ou das temáticas de outras que não chegaram aos nossos dias, bem como da análise de algumas passagens dos escritos filosóficos e estéticos de Platão e Aristóteles, buscamos compreender essa possível presença do maravilhoso possibilitado pelo riso e o cômico, talvez podendo indicar futuros caminhos de análise. Neste aspecto, também nos é importante a referência a uma obra teórica específica, na verdade, o resumo de uma possível aula ou escrito anterior, hoje perdido, intitulado hodiernamente Tractatus coislinianus, que oferece – ou, ao menos, sugere – uma possibilidade teórica dessa possível plasmação do maravilhoso na comédia, já que o riso e o cômico podem proporcionar uma nova perspectiva ou prisma que incrementa a própria percepção do thaumaston.
A morte fala sério mesmo quando faz rir: o riso desconcertante de José Saramago
Authors: De Aquino Gomes Carolina
Published: September 2021

Conhecido por romances que tratam de temas sérios e edificantes, José Saramago, em sua última fase de produção romanesca, nos apresenta uma face humorística, que compreende os três últimos romances publicados em vida. Neste artigo, buscamos fazer uma leitura do primeiro dessa tríade, As intermitências da morte (2005), em que nos é apresentado um universo insólito a partir da greve de uma morte-personagem a reivindicar seus direitos de ser notada. Assunto sério por excelência, é trabalhado através do humor, e ocasiona um riso desconcertante no leitor, impelindo-o a refletir sobre sua própria condição de ser humano. Com base nos estudos de Hutcheon (1985), Duarte (2006), Propp (1992), D’Angelli e Paduano (2007), Alberti (1999), Minois (2003) e Roas (2014), é possível observar como a narrativa transcende a realidade, subvertendo-a pelo riso, pela paródia e pela ironia, assim como pelo recurso ao fantástico. Esses elementos são responsáveis por motivar uma nova reflexão sobre o tema da morte. O riso desconcertante nesse romance atua como um indício de que é preciso revermos nossa forma de enxergar a morte e nos transformarmos a partir dessa reflexão. É possível inferir que, por meio do fantástico, Saramago estimula o desenvolvimento intelectual e ético do sujeito e nos exige ousadia para transcender o velho e encontrar um novo significado para a morte.
Experimental investigation of a one-level eight-channel cyclone-separator incorporating quarter-rings
Authors: Chlebnikovas Aleksandras
Published: September 2021

The main aim of this investigation was an experimental analysis of the air
cleaning efficiency in a mock-up next-generation air cleaning device -
one-level 8-channel industrial cyclone-separator with quarter-rings - while
changing parameters of the inner structure and the assessment of the effects
of dispersion of particulate matter. Therefore, the research was carried out
in two stages: the first stage covered the analysis of the efficiency of the
multi-channel cyclone with particulate matter of <20 and <50 ?m. During the
second stage, a cascade impactor was used to measure the particle collection
efficiency in the multi-channel cyclone by fractions: PM1, PM2.5 and PM10.
Results of the tests with using the cascade impactor were compared to show
changes in the PM composition before and after the multi-channel
cyclone-separator. According to the obtained experimental data, the
one-level 8-channel cyclone-separator collects 70 to 80 % of PM up to 10 ?m
in size, 45 to 60 % of PM up to 2.5 ?m in size and 21 to 25 % of PM up to 1
?m in size.