bluuebunny/crossref_metadata_2025 huggingface dataset:
SINTESIS KEMOSENSOR ION CN- BERBASIS TURUNAN PIRAZOLIN DENGAN LOGAM Cu
Authors: Syahputri Yulian , Purwati Diah Indah , Sutanto Sutanto , Taufiq Agus
Published: June 2022

One of the toxic anions such as cyanide (CN-) has a negative impact on living things. Pyrazoline derivatives can be complexed with transition metals and used as CN- ion fluorosensor, because pyrazoline derivatives have fluorescence properties. This study aims to synthesize of CN- ion chemosensors based on pyrazoline derivative namely para-di-2-(1-phenyl-3-pyridyl-4,5-dihydro-1H-pyrazole-5-yl)benzene with Cu metal. The resulting complex compounds were characterized using Spectrophotometer Infra Red (FTIR), Spectrophotometer UV-Visible, and Spectrofluorometer. Then, a complex compound chemosensor (fluorosensor) study of Cu2+ was carried out with the addition of CN- ions using a spectrofluorometer. The results showed that the synthesis of complex compound Cu2+ was successfully carried out and a brown precipitate was obtained with a yield of 43% with a melting point of 243.3°C. Based on the results of characterization by FTIR (cm-1) generates 3400 (Amine), 2920.88-2852.42 (C-H pyridine), 2360.38 (C=N), 1594.50-1490.39 (C=C aromatic), 1233.67-1021.17 (C-N),  982.66 (Cu-O), 348.00 (Cu-N), and 320-280 (Cu-Cl). The results of the spectroscopy UV-Visible analysis Cu2+ complex compounds at a concentration of 5x10-5 M obtained two absorption peaks, 242 nm and 306 nm. The result of the spectrofluorometer analysis of Cu2+ complex compound were 1516 a.u at a wavelength of 502 nm. The results of the chemosensor (fluorosensor) studies of the Cu2+ complex compound with the addition of CN- ions can be used as a turn on-off  type fluorosensor.
PENGARUH PENAMBAHAN EKSTRAK KUNYIT (Curcuma domestica Val.) PADA PAKAN TERHADAP PERTUMBUHAN IKAN NILA (Oreo chromis niloticus)
Authors: Prihandini Agnita , Umami Muhimatul
Published: June 2022

In the cultivation of tilapia (Oreochromis niloticus), there are still some obstacles or obstacles that farmers complain about, one of which is the high price of commercial feed, because one of the most important factors in cultivation is quality feed. Fish growth will increase if the feed given can be digested properly by fish so that the energy obtained by fish from feed can be utilized optimally. Therefore, with the background of some of the problems above, it is necessary to add natural feed in tilapia cultivation, with a nutritional composition that is in accordance with the needs of fish, this study was conducted with the aim of knowing the effect of adding natural feed in the form of turmeric extract as an immunostimulant that can trigger the growth of tilapia, as well as to determine the effect of differences in the concentration of turmeric extract added to each tilapia feed on the growth rate (weight and body length) of tilapia. This research was conducted through an experimental method, where the treatment given was in the form of adding turmeric extract with different concentrations to the artificial feed of tilapia. The results of this study proved that the higher the dose of turmeric extract added to the feed, the higher the growth rate of body length and weight of the tilapia. This is due to the balance of protein, and has the main content in the rhizome, namely essential oils and curcumin which can increase appetite, and also acts as an antioxidant.
PERBANDINGAN KADAR FLAVONOID EKSTRAK ETANOL DAUN KELENGKENG (Dimocarpus logan L.) DENGAN VARIASI METODE EKSTRAKSI
Authors: Rusli Zaldy , Yulianita Yulianita , Sitanggang Elfrida Erawati
Published: June 2022

Longan plants (Dimocarpus logan L.) are generally used by the community only for their fruit. Longan leaves contain secondary metabolites such as flavonoids, polyphenols, saponins, and tannins. Flavonoids are polyphenolic compounds and have antioxidant properties that are not heat-resistant, therefore a suitable method is needed for extracting flavonoids, especially methods that do not use heat. Maceration extraction method is an extraction method by immersing simplicia at room temperature, while the Microwave Assisted Extraction (MAE) extraction method is an extraction method using microwave radiation. The study aims to determine the most effective method for flavonoid content of longan leaves using 2 extraction methods, namely maceration and MAE. Determination of flavonoid content was done using Aluminium chloride reagent whose absoption was measured using UV-Vis spectrophotometry. The results showed that the best extraction method to produce the highest flavonoid content in 70% ethanol extract of longan leaves was the Microwace Assisted Extraction method which produced flavonoid levels of 1.32 ± 0,09%.
Addition of Maltodextrin Concentration to Anthocyanin Characteristics and Levels in the Manufacture of Natural Dyes from the Skin of Red Dragon Fruit (Hylocereus polyrhizus)
Authors: Herlina Eka , Widiastuti Diana , Annissa Fatwa Rachmawati
Published: June 2022

Synthetic dyes in food products can cause health problems, making some people reduce such products' consumption. Alternatively, instead of avoiding consumption, people can do better by switching to natural dyes in food processing. One possible solution is to use the red dragon fruit's skin (hylocereus polyrhizus), containing anthocyanin pigments of the cyanidin-3-glucoside type. The purpose of this study is to propose the use of red dragon fruit's skin as a natural dye and to determine the characteristics, anthocyanin levels, and shelf life of red dragon fruit peel dye. The making of red dragon fruit peel dye was done by first extracting it with a maceration technique. After that, maltodextrin was added to the filtrate while the drying temperature was carried out at 28°C and 13°C. The results showed that natural dyes with a concentration of 30% maltodextrin at 13° C were the selected dyes and had the best characteristics. The total yield analysis resulted was 11.30%; pH measurement of 4.24; water content of 1.03%; solubility of 98.08%; color intensity L value of 59.41; a value of 33.44; and the b value of -7.78. The results obtained from the analysis of anthocyanin levels were 15.0290 ppm. The total plate number test obtained is 2.1 x 102 colonies/gram with a storage life of 282 days.
Chicken Bone Based Adsorbent for Adsorption of Pb(II), Cd(II), and Hg(II) Metals Ion Liquid Waste
Authors: Hasanah Uswatun , Iryani Ani , Taufiq Agus , Darma Putra Dimas Apryandi
Published: June 2022

High productivity of chicken meat for supplying society also make some impact in high productivity of chicken bone and because it’s unraveling properties makes this become waste. Pharmaceutical’s Waste comes from production process, adstertion of production tools, laboratory activities and rejected product. Laboratory’s routine analysis also producing residual waste analysis, one of the source is come from heavy metals analysis of Pb, Cd, dan Hg. General process for waste treatment producing high quantity of sludge, mean while using third party service have impact in high costing of transportation and treatment process. An alternatif way for this case is using sorption treatment. Initial research starts from preparation of chicken bone-based adsorbent and its characterization using SEM and FTIR, followed by quality analysis of fresh waste (which is waste A and waste B) observed at pH, COD, TDS, TSS also Pb, Cd, dan Hg metals. Adsorption process was observed from adsorbent’s graying temperature, adsorbent’s particle size, contact time, pH of waste, and adsorbent’s weight. Best result from adsorption process were applicated at fresh waste and simulation waste of Pb, Cd, and Hg metals also re-testing quality analysis of fresh waste and simulation waste for before-after result comparing purpose. The purpose of this research is for characterizing chicken bone-based adsorbent, observing adsorption process of  Characterization of chicken bone ash based adsorbent has been carried out in adsorbing Pb, Cd, and Hg metals in pharmaceutical laboratory waste. Functional group analysis with Fourier Transform Infrared Spectrophotometer (FTIR) showed that the chicken bone ash adsorbent contained the mineral compound apatite carbonate. Surface morphology with a Scanning Electron Microscope (SEM) shows that the adsorbent surface is porous and appears to be adsorbing metals. From the adsorption observations, it was found that the best adsorption conditions were at an ashing temperature of 800 oC, particle size of 80 mesh, contact time of 30 minutes, waste conditions at pH 6 and an adsorbent weight of 600 mg. Application chicken bone-based adsorbent against pharmaceutical waste shows its existence improve the quality of waste but still do not meet the quality standard requirements for Hg metal.
Synthesis of Ligand para-di-2-(1-phenyl-3-pyridyl-4,5-dihydro-1H-pyrazol-5-yl) benzene by Aldol Condensation Method
Authors: Syahputri Yulian , Sutanto Sutanto , Kusumawardani Linda Jati
Published: June 2022

Synthesis of pyrazoline derivative ligand para-di-2-(1-phenyl-3-pyridyl-4,5-dihydro-1H-pyrazol-5-yl)benzene has been successfully carried out by aldol condensation method using 2-acetyl pyridine and terephthalaldehyde in ethanol solution. The synthesis results are then reacted with excess phenyl hydrazine. The yield of ligand obtainedwas 63.10% of ayellow solid. The ligand was characterized using 1H-NMR spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, fourier transform infra-red (FTIR) spectroscopy and spectrofluorometer. The characterization with UV-Vis spectrophotometer results shows ligand has a large value of molar absorptivity (ε) at wavelength 236 nm and concentration 5x10-5 M.The results indicates that the ligand has a strong fluorescence intensity. It proved by peak emission at 467.5 nm (I = 4055 a.u).
Optimization of The Addition Of Polivinil Alcohol (PVA) as A Plasticizer In Biofilm with Tapioca-Chitosan Flour Material
Authors: Aminingsih Tri , Heliawati Leny , Fathurrahman Muhammad
Published: June 2022

The addition of a plasticizer, namely polyvinyl alcohol (PVA) as a plasticizer, will increase flexibility and prevent the polymer from cracking. The purpose of this study was to compare the mechanical properties of biofilms from tapioca-chitosan flour with or without the addition of polyvinyl alcohol (PVA) and determine the mass of polyvinyl alcohol (PVA) which can provide optimum mechanical properties of biofilms, test the biodegradability of biofilms and polypropylene plastics and to analyze biofilms using FT-IR. The making of biofilm from 4% tapioca flour and 2% chitosan was carried out by adding variations of polyvinyl alcohol as much as 0, 1, 2, 3, 4 and 5 grams to each tapioca-chitosan flour solution. The effect of adding polyvinyl alcohol (PVA) can be seen from the results of the tensile strength test, the breaking length test, the water resistance test and the biodegradability test. The resulting biofilm functional group analysis was performed by FT-IR. The results showed that the addition of PVA could increase the tensile strength and breaking length, but decreased the water resistance of the biofilm. The optimum mechanical properties of tapioca-chitosan flour biofilm resulted from the addition of 3 grams of PVA with a tensile strength of 2.163 kgf / cm2, the breaking length of 13.64% and 12.46% of absorbed water. Biofilms can be degraded by the fungus Aspergilus niger. The results of biofilm analysis using FTIR indicate the presence of functional groups (CH, NH2, NH, OH, CO and CN) which are the functional groups of the biofilm constituent materials. The optimum mechanical properties of tapioca-chitosan flour biofilm resulted from the addition of 3 grams of PVA with a tensile strength of 2.163 kgf / cm2, the breaking length of 13.64% and 12.46% of absorbed water. Biofilms can be degraded by the fungus Aspergilus niger. The results of biofilm analysis using FT-IR indicate the presence of functional groups (CH, NH2, NH, OH, CO and CN) which are the functional groups of the biofilm constituent materials.
COFFEE GROUND ACTIVATED CHARCOAL AND ITS POTENTIAL AS AN ADSORBENT OF Ca2+ AND Mg2+ IONS IN REDUCING WATER HARDNESS
Authors: Mustaqim Achmad Khaerul , Sutanto Sutanto , Syahputri Yulian
Published: June 2022

Residents of Ciaruteun Udik Village experienced complaints about the well water they use, namely the presence of scale on cooking utensils, soap is difficult to foam, and indigestion due to consuming hard water. One way to reduce water hardness is by adsorption. Coffee grounds can be used as activated charcoal and function as an adsorbent for calcium and magnesium metal ions. The purpose of this study was to determine the optimum contact time, pH, and weight of coffee grounds in the maximum adsorption of hardness in water. This study begins with the preparation of samples in hard water and coffee grounds, namely by activation with HCl, then the FTIR test of coffee grounds before and after activation. Activated coffee grounds charcoal was tested for adsorption capacity against hardness in water with variations in contact time, pH, and weight of the adsorbent. The results showed that coffee grounds activated charcoal can be used as an adsorbent in reducing water hardness. The optimum pH and contact time of coffee grounds activated charcoal in adsorption of hardness in water was at a contact time of 75 minutes and pH 7 with a hardness level in water of 565.17 mg CaCO3/L decreasing to 56 mg CaCO3/L. The optimum weight of coffee grounds activated charcoal in adsorption of hardness in water was 10 grams with hardness levels in water from 565.17 mg CaCO3/L decreasing to 12 mg CaCO3/L.
IDENTIFICATION OF ANTIBACTERIAL COMPOUNDS FROM ENDOPHYTIC BACTERIAL EXTRACT OF GREEN GRASS CINCAU PLANT (PREMNA OBLONGIFOLIA MERR)
Authors: Soliha Anna Muthia , Heliawati Leny , Warnasih Siti
Published: June 2022

Green grass jelly (Premna oblongifolia Merr) is a plant that belongs to the Verbenaceae family with the Premna genus. The genus Premna has about 200 species in the Verbenaceae family which are spread in tropical to subtropical areas such as Asia, Africa, and Australia. This plant has potential as antibacterial, antipyretic, anti-inflammatory, and antioxidant. This research was conducted to make an extract of endophytic bacteria obtained from green grass jelly plants by maceration method. The extract obtained was tested for its antibacterial activity by disc diffusion method. Extracts with the highest antibacterial activity were identified by FTIR and GCMS. The results showed that the methanol extract of endophytic bacteria of green grass jelly plants had broad spectrum antibacterial activity because it was able to inhibit the growth of Gram-positive bacteria (Bacillus subtilis) and Gram-negative bacteria (Pseudomonas aeruginosa). The results of FTIR and GCMS showed that the active compounds contained in the endophytic bacteria of green grass jelly plants were thought to be Nerolidol compounds or 3,7,11-trimethyl-1,6,10-dokatrien-3-ol which are secondary metabolites of the sesquiterpene alcohol group and play a role in as an antibacterial.
UREA CORE COATING WITH CROSSLINKED HYDROPHILIC POLIMERS FOR CONTROLLED RELEASE FERTILIZER APPLICATION
Authors: Sujono Sujono , Mas’ud Zainal A.
Published: June 2022

Controlled release fertilizer (CRF) can be made by coating the fertilizer core with a polymer layer. The simultaneous coating reaction of the polymerization needs to be controlled in the reactor. A controlled reactor system was developed for the polymerization of granular fertilizer coating using integrated electronic control of the 8-bit ATTiny 2313 AVR microcontroller chip. Urea granule fertilizer is coated with hydrophilic polymer polyacrylamide and crosslinked polyacrylate with N,N'-methylene-bis acrylamide (MBA). The reaction was initiated by benzoyl peroxide (BPO) at 61 oC. The coating was successfully formed in 45 minutes reaction. The coating process in the control reactor was more effective than without control, thereby reducing the deposition of polymer deposits that did not coat the fertilizer. The characterization of the fertilizer coating layer based on infrared spectroscopy (FTIR) showed that polymerization synthesis had occurred based on the presence of C=C bonds. The IR spectrum showed a reduced absorption of the C=C stretching vibration medium in the acrylamide monomer compared with the polymer (crosslinked polyacrylamide), namely the wavenumbers of 1614 cm-1 in acrylamide and 1601 cm-1 in polyacrylamide spectrum. Similarly, the loss of C=C absorption in the crosslinked polyacrylate spectrum but appeared in the acrylic monomer spectrum at 1636 cm-1 wave. This group is reduced or lost after polymerization due to an addition reaction.
STUDY OF REACTION KINETICS AND IDENTIFICATION OF CLOTRIMAZOLE DEGRADATION COMPOUNDS IN ANTI-FUNGAL CREAM PREPARATIONS
Authors: Batubara Cellia Christiana , Iryani Ani , Kusumawardani Linda Jati
Published: June 2022

Fungal infections of the skin can be treated with antifungal compounds, one of which is clotrimazole. Under certain conditions, clotrimazole can be degraded to imidazole and (o-chlorophenyl) diphenyl methanol which can cause skin irritation. This is because the storage conditions of the drug product during or after use if it is not suitable, can interfere with the stability of the drug product. Therefore, this study was conducted to obtain information regarding changes in clotrimazole levels, reaction order, reaction constant value, half-life, activation energy, and the possibility of compounds formed after the clotrimazole degradation process to determine the good storage conditions of the product. Clotrimazole levels were tested in the open and closed state of the packaging every day at different storage temperatures for three months. Changes in clotrimazole levels were measured using HPLC every week. In addition, the identification of compounds resulting from degradation was also tested using HPLC every month and continued using LC-MS/MS in the last week. The results of the analysis of clotrimazole levels, there was a decrease in levels but still in accordance with the specifications required by the Indonesian Pharmacopoeia. The greatest decrease in levels occurred in samples stored at a temperature of 40±2oC which reached 9133%. The decrease in clotrimazole levels followed a first-order reaction with the shortest half-life of 90 weeks and activation energy of 18.9 kJ/mol. Identification of the degraded compounds using HPLC and LC-MS/MS found imidazole compounds and (o-chlorophenyl) diphenyl methanol in samples stored at 25±2oC and 40±2oC. These compounds can cause skin irritation, but these compounds may not have a serious impact because they have a fairly large body threshold value of 220 mg/kg. This shows that clotrimazole cream stored at various temperatures, both at 5±2oC, 25±2oC, and 40±2oC can still be used for three months after the packaging is opened according to the in-use shelf life.
PENGARUH JUMLAH UANG BEREDAR DAN TINGKAT SUKU BUNGA TERHADAP KURS RUPIAH MENGGUNAKAN VECTOR ERROR CORRECTION MODEL
Authors: Edris Wilda Irvana , Virgantari Fitria , Andriyati Ani
Published: June 2022

This study aims to determine the influence on the estimated short-term and long-term relationships of the VECM (Vector Error Corrction Model), the casuality relationship of the three variables, and the length of response effect time when achieving stability. The data used is monthly data for the period 2007 - 2017. The estimated result obtained by the model is VECM at lag 2 with the results of the short-term estimate KURSt = - 0.257 KURSt-1 - 0.289 KURSt-2 - 0.029 TSBt-1, JUBt = 0.015 - 0.369 KURSt-2 - 0.208 JUBt-1- 0.202 JUBt-2, TSBt = 0.275 TSBt-1 + 0.353 TSBt-2 where t time period and long-term estimated results that the amount of money in circulation and the interest rate negatively affect the rupiah exchange rate. In granger casuality test, there is only a direct relationship between the rupiah exchange rate and the amount of money in circulation and the interest rate with the rupiah exchange rate. Based on the analysis of impulse response function, when given the shock of interest rate and rupiah exchange rate itself, the effect of rupiah exchange rate response is stable in the 22nd period and the 15th period, when given the shock of rupiah exchange rate and the amount of money in circulation itself, the effect of the response of the amount of money in circulation is stable in the 10th period and when given the shock of the interest rate itself, the effect of the response of the interest rate is stable in the 18th period.Keywords: impulse response function. interest rate, money supply, rupiah exchange rate, VECM model
SISTEM PENDUKUNG KEPUTUSAN PEMENANG TENDER DALAM PROSES PELELANGAN BARANG DAN JASA DENGAN MENGGUNAKAN METODE PROMETHEE
Authors: Putri Fernanda Caesari , Widyastiti Maya , Sumarsa Amar
Published: June 2022

Supporting factors for carrying out a production process is the existence of the auction selection process in the supply of goods that will go into the logistics plan. In the auction at the UPT Balai Yasa Manggarai PT. Indonesian Railways still have many human errors, so the qualification evaluation process is carried out by asking and checking all bid documents. Determine the winner of the participant auction so that it can assist the logistics plan in the selection bidders using Promethee. The alternatives used are 10 tenders and 5 criteria as valuation namely company registration criteria (C1), financial statement criteria (C2), trade mark permit criteria (C3), taxable criteria (C4), domicile criteria (C5). The method used in the study is the Promethe method. This developed system shows that the best auction participant at UPT BY MRI is PT BHINEKA KARTA PUTRA MANDIRI with a net flow value of 0.28889. Therefore, this study aims to develop a Decision Support System (DSS) to determine the winner of bidders in the objective auction of goods and services. This research is expected to help in determining tenders by minimizing human error.Keywords: Decision Support System, Promethee Method, Winning Bidder.
PEMODELAN VEISV DENGAN PENANGGULANGAN KARANTINA DAN VAKSINASI PADA PENYEBARAN VIRUS KOMPUTER
Authors: Gunawan Ridwan , Wijayanti Hagni
Published: June 2022

At this time computers and the Internet has become our daily needs, If the computer or the Internet network is disrupted, then it will interfere with our daily productivity. Usually computers and Internet will be disrupted if attacked by a virus, it can anticipate the computer's interference so as not to happen mass destruction on the computer or barriers to our daily productivity, we need to know the pattern of the spread of the Internet virus. Mathematical modelling can be one method to know the pattern of the spread of computer virus, so that if there is increasing the spread can be minimized. The models used in this study are VEISV models with Quarantine and Vaccination Enhancement. From the model get a reproduction number. Based on stability analysis of fixed point with criterion of Routh-Hurtwitz obtained first fixed point and second fixed point, then done arrangement of syntax to know rate of spread of computer virus. From the analysis results obtained the pattern of the spread of computer virus on virus free condition and virus infected.Keywords: Computer Virus, Quarantine and Vaccination, VEISV.
MODEL WAKTU TUNGGU KENDARAAN DI PERSIMPANGAN LALU LINTAS MENGGUNAKAN DISTRIBUSI COMPOUND POISSON ARRIVALS
Authors: . Nani , Wijayanti Hagni , Virgantari Fitria
Published: June 2022

This study aims to apply mathematical models of traffic conditions at crossroads and determine the length of waiting times for vehicles with compound poissson distribution arrival patterns as well as determine the length of the green light phase and red light phase so that reduce traffic congestion at intersections. The data used is data from the Bogor Highway Transport Traffic Agency (DLLAJR) in 2017.  The initial stage of analysis is to divide the waiting time of the vehicle into 2 phases, namely the red light phase and the green light phase. After that apply the Compound Poissson distribution model for the red light phase and the green light phase, then determine the vehicle's waiting time. The next step is the application and simulation of one-cycle vehicle waiting time on Simpang Yasmin road. Based on the results of the analysis, it can be concluded that the waiting time for vehicles in Simpang Yasmin is 80 seconds for each cycle. Simulation produced on the road section in Simpang Yasmin namely Jl. K. H. Sholeh Iskandar (west) for 28 seconds green light time, Jl. K. H Sholeh Iskandar (east) for 16 seconds green light time, and Jl. K. H. Abdullah bin Nuh for 27 seconds green light time.Keywords: green light time, one-cycle vehicle waiting time, Poisson compound distribution, yasmin intersection.
OPTIMASI BIAYA DISTRIBUSI AIR MINUM DALAM KEMASAN MENGGUNAKAN ALGORITMA ANT COLONY SYSTEM (Studi Kasus : PT. Tirta Investama Cibinong)
Authors: Samsudin Mulyana , Wijayanti Hagni , Setyaningsih Sri
Published: June 2022

Aqua is a brand of bottled drinking water produced by PT Aqua Golden Mississippi Tbk. The products produced by PT Aqua Golden Mississippi Tbk are distributed by PT Tirta Investama Cibinong. PT Tirta Investama Cibinong distributed the 15 stores spread across several areas, the distribution of the 15 existing stores could be done by various routes. In its distribution activities, the company does not yet have an optimal route, so the most optimal route is needed so that the costs incurred are minimum. Ant Colony System Algorithm is a method that aims to find the best path in a distribution problem, based on the behavior of ants. The purpose of this study is to obtain the minimum cost in delivering bottled drinking water to several areas using the Ant Colony System Algorithm so as to meet the demand for mineral water in the area. The data used is shipping costs between stores in 2018. It is certain that the Ant Colony System Algorithm obtains the optimal path from Cibinong Depot, Indomaret Cibedug, Alfamidi Gadog, PT Sumber Alfaria Trijaya TBK, Pujasari, PT Sumber Alfaria Trijaya, Lion Superindo Town Square, TipTop Depok, Indomaret Happiness Raya, Lion Superindo Depok, Lion Superindo Cibubur, DC Starmart, Pajajaran gas station, Circle K Sudirman Bogor, Wholesale Lotte Bogor and finally back to Depo Cibinong with shipping costs of Rp. 244,420. Keywords: Ants, Ant Colony System, Traveling Salesman Problem
METODE TAGUCHI DALAM ANALISIS PENGENDALIAN KUALITAS PRODUK FURNITURE
Authors: Octariani Irna , Virgantari Fitria , Wijayanti Hagni
Published: June 2022

This research was conducted to analyze the quality control of furniture products in PT. Hadinata Brothers, to find the cause of product quality that did not match specifications, the causative factors of significant defective products, to find an optimal combination of settings and minimized defective products in order to maintain good quality using the Taguchi Method. The data used in this study is data on defective products in PT. Hadinata Brothers. Furthermore, the data is processed using several methods including pareto diagram, causal diagram (fishbone), Taguchi Method, Analysis of Variance (ANOVA). From the results of the analysis, the control of defective products 36.4% was outside the lower limit of control and 85.7% was outside the upper limit of control with the limits of control CL = 0.0572, UCL = 0.0818, LCL = 0. The highest percentage of defects is handling, which is 59.5%, the second order is assembly, which is 23.3%, and the third is finishing, which is 17.2%. Factors that significantly affect the quality of products based on the results of ANOVA calculations are factor A (handling raw materials) and factor B (type of wood) because Fcalc F-table which are 6.2178 2, 37 and 2.3895 2.37. Keywords: quality control, Taguchi Method, defective products, causative factors defect, pareto diagram, fishbone, ANOVA
PENGELOMPOKAN WILAYAH BERDASARKAN FAKTOR PENDUKUNG PENDIDIKAN DENGAN JUMLAH SEKOLAH DAN JUMLAH GURU MENGGUNAKAN ALGORITMA K-MEANS
Authors: Dewi Elgi Yani Tri Putri , Kamila Isti
Published: June 2022

Education is one field that has a role in creating human resources and national development. The national education system states that the government can ensure equal distribution of education, quality improvement, the relevance and efficiency of education management. The implementation of education in regions of Indonesia has obstacles, including in remote areas have not been evenly distributed in accessing education services. The provision of schools and teaching staff is a supporting factors for teaching and learning activities. All regions, including sub-districts in Cianjur Regency. One of the efforts for equity is to use the k-means method to classifysub-districts in Cianjur Regency in the provision of schools and teachers by the Government. The data used number of schools and teachers at the elementary school, junior high school, high school and vocation high school level in every sub-district in Cianjur Regerency in 2020. The results that have been researched show two clusters.Cluster 1 or an area that has several schools and the number of teachers lacked in Cianjur Regency consisting of 21 sub-districts and cluster 2 or an area had a better number of schools and the number of teachers than cluster 1 in Cianjur Regency consisting of 11 sub-districts.
METODE DOUBLE EXPONENTIAL SMOOTHING DALAM PERAMALAN JUMLAH PEMOHON PASPOR (Studi Kasus : Kantor Imigrasi Kelas II Non-TPI Depok)
Authors: Seno Natalia Medya Lifa Ir , Kamila Isti
Published: June 2022

The Immigration Office of Class II Non-TPI Depok City is an institution that provides services engaged in the field of immigration, one of which is providing passport processing services. This increase in the number of passport applicants will have an impact on the availability of facilities, infrastructure, and passport management services which often reach 2000 – 3000 passports per month in 2018. From the problems above, the author offers a solution, namely by predicting the number of passport applicants. There are several methods used to solve this problem, including the double exponential smoothing method as the method that will be tested in this study This method uses parameter values obtained from trial and error calculations to produce accurate values because the data is fluctuating so it requires smoothing parameters. If the data used a lot in the calculation of forecasting then MAPE (Mean Absolute Percentage Error) forecasting will be smaller and vice versa . The results of the forecasting of passport creation applications produced by the Double Exponential Smoothing Method with a parameter of α = 0.4 (selection of the best alpha between 0 to 1) obtained a MAPE value of 14.28%. MAPE criteria that are worth 14.28% belong to the category of GOOD in forecasting the application for passport creation in the period to be obtained.
FORMULASI, KARAKTERISASI DAN EVALUASI SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) EKSTRAK ETANOL KULIT BUAH NANAS SEBAGAI ANTIBAKTERI STREPTOCOCCUS MUTANS
Authors: Indratmoko Septiana , . Suratmi , Issusilaningtyas Elisa
Published: June 2022

Kulit buah nanas mengandung bromelain, flavonoid, tannin, dan saponin yang dapat dimanfaatkan sebagai antibakteri. Perkembangan teknologi formulasi diperlukan untuk meningkatkan aktivitas antibakteri. Ekstrak kulit buah nanas memiliki sifat kurang larut dalam air sehingga efek farmakologinya terbatas. Formulasi SNEDDS diharapkan mampu meningkatkan aktivitas antibakteri agar dapat bekerja secara maksimal. Penelitian ini bertujuan untuk mengetahui formula optimum SNEDDS ekstrak kulit buah nanas, karakterisasi nanoemulsi dan aktivitas antibakteri. Pengujian terhadap 14 formula dari Simplex Lattice Design menghasilkan formula optimal SNEDDS ekstrak kulit buah nanas dengan komposisi 1 (VCO) : 5 (surfaktan) : 1 (kosurfaktan) dengan desirability 0,995 dan uji drug loading 100 mg/5 mL. Uji karakterisasi  berupa pengukuran droplet size dengan rata-rata 15,06 nm, potensial zeta -14,3 mV, transmitan 98,6%, emulsification time 24:93 detik, uji stabilitas fisik stabil. Uji antibakteri dilakukan dengan metode sumuran. Daya antibakteri SNEDDS ekstrak kulit buah nanas terhadap bakteri Streptococcus mutans tergolong kuat dengan ukuran zona bening 11,19 mm.
REVIEW: KAJIAN SINTESIS MOLECULAR IMPRINTED POLYMER (MIP) UNTUK PENENTUAN ANABOLIK ANDROGENIK STEROID
Authors: Komalasari Nensa , Suryana Shendi , Soni Dang
Published: June 2022

Molecular Imprinted Polymer (MIP) merupakan teknik pembuatan polimer berongga yang berfungsi sebagai sorben dengan selektivitas dan afinitas yang tinggi. Keberhasilan teknik MIP dalam pengaplikasiannya dilihat dari seberapa tingginya nilai imprinting factor (IF) dan kapasitas adsorpsi (KA) dalam mengadsorpsi suatu analit target. Tingginya kedua parameter tersebut dapat dipengaruhi oleh penggunaan monomer dan crosslinkers pada saat sintesis polimerisasi MIP. Tujuan dilakukan studi ini untuk memberikan informasi berupa nilai parameter IF dan KA dari penerapan MIP pada senyawa obat anabolik androgenik steroid (AAS). Review Jurnal ini dilakukan dengan menelusuri dan mengkaji jurnal ilmiah nasional maupun internasional tentang MIP dan AAS yang diperoleh dari situs google.com, google scholar, NCBI, dan Science Direct. Berdasarkan hasil review untuk memperoleh nilai IF dan KA yang tinggi bagi analit testosteron jika monomer yang digunakan adalah trifluoromethacrylic acid (TFMAA) yang dikombinasikan dengan crosslinker divinylbenzene (DVB) dan androsterone dimethacrylate (AnDMA), untuk analit estrogen seperti β-estradiol memperoleh nilai IF dan KA yang tinggi jika monomer yang digunakan adalah methacrylic acid (MAA) yang dikombinasikan dengan crosslinker ethylene glycol dimethacrylate (EGDMA).
UJI AKTIVITAS EKSTRAK ETANOL 96% DAN FRAKSI DAUN KIRINYUH (Chromolaena odorata L.) TERHADAP PROPIONIBACTERIUM ACNES
Authors: Komala Oom , . Yulianita , Rahmawati Rita
Published: June 2022

Chromolaena odorata L. leaves can be used as an antibacterial because of contain flavonoid compounds. The secondary metabolite content of Chromolaena odorata L leaves include flavonoids, tannins, saponins, and steroids which have antibacterial activity. The aim of this study was determine the antibacterial activity of  ethanolic 96% and fraction of Chromolaena odorata L leaves and determine the concentration of  Chromolaena odorata L fraction and ethanol 96% extract which was most effective as an antibacterial against Propionibacterium acnes. The method was used to determine the MIC was a solid dilusion method, while the determination of inhibitory zone by the paper disk diffusion method at concentrations of 10%, 15% and 20% in each sample. The MIC showed hexane fraction is 15%, ethylacetate fraction is 15% and water fraction is 10%. The best antibacterial activity in the ethylacetate fraction and ethanol 96% extract  at a concentration of 20% with the width of the zone of inhibition values of 4.375 mm and 4 mm.
PENETAPAN ALPHA HYDROXY ACID SARI BUAH CEREMAI (Phyllanthus acidus L.) DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI
Authors: Indriatmoko Dimas Danang , Suryani Nani , Rudiana Tarso , Kurniah Mila
Published: June 2022

Alpha Hydroxy Acid (AHA) adalah asam organik yang terdiri dari 2 (dua) rantai karbon atau lebih yang semakin panjang rantai karbonnya akan semakin besar berat molekulnya. AHA adalah kelas senyawa kimia yang sering digunakan dalam kosmetik dan dermatologi. Beberapa buah dilaporkan mengandung senyawa AHA yaitu, asam sitrat dalam buah jeruk dan nanas, asam glikolat dalam tebu, asam laktat dalam tomat, asam malat dalam apel dan anggur, dan asam tartrat dalam anggur. Penelitian ini dilakukan untuk menetapkan kadar AHA yang terkandung dalam buah ceremai (Phyllanthus acidus L.) dengan menggunakan metode Kromatografi Cair Kinerja Tinggi (KCKT). Sari buah P.acidus dikeringkan dengan metode pengeringan beku. Kemudian senyawa AHA dalam ekstrak kering P.acidus yaitu asam glikolat dan asam sitrat dianalisis menggunakan KCKT dengan jenis kolom Capcell PAK C18 UG120S-5mm(4,6 X 250 mm); detektor UV Vis 210 nm; kecepatan alir 0,5 ml/menit; fase gerak asam fosfat dan asetonitril. Hasil penetapan kadar menunjukkan bahwa kadar asam glikolat dan asam sitrat masing-masing adalah 27,8 % dan 39,8 %.
FORMULASI DAN AKTIVITAS ANTIOKSIDAN SERBUK MINUMAN INSTAN SARI BUAH TOMAT (Solanum lycopersicum)
Authors: Zaddana Cantika , . Almasyhuri , Meida Ulfa
Published: June 2022

Tomat merupakan buah yang mengandung beberapa senyawa antioksidan diantaranya licopen, fenolik, flavonoid, vitamin C dan vitamin E. Sari buah tomat dibuat sediaan serbuk minuman instan yang praktis dalam penyajian. Penelitian ini bertujuan untuk untuk menentukan formula serbuk instan sari buah tomat yang disukai panelis sesuai dengan persyaratan mutu dan menentukan aktivitas antioksidan dari formula terbaik. Metode penelitian ini meliputi pembuatan serbuk tomat dengan metode freeze dry, formulasi serbuk instan, evaluasi sediaan mutu, uji hedonik, penetapan kadar vitamin C, penetapan β- karoten dan uji aktivitas antioksidan. Formula yang dibuat dengan perbedaan konsentrasi serbuk sari buah tomat yaitu F1 (2.5%), F2 (10%) dan F3 (20%). Hasil penelitian menunjukan bahwa F2 merupakan formula yang paling disukai panelis. Hasil penetapan kadar vitamin C serbuk sari buah tomat dan serbuk instan buah tomat masing – masing didapat nilai sebesar 9.62% dan 1.98%. Penetapan kadar β-karoten masing-masing untuk serbuk sari buah tomat dan serbuk instan sari buah tomat didapat 0.20 mg/kg dan 0.10 mg/kg dan untuk uji aktivitas antioksidan didapat nilai IC50 dari serbuk sari tomat 60.86 ppm (aktif) dan serbuk instan sari tomat 90.30 ppm (aktif).
STUDI PERBANDINGAN EFEK DIURETIK DAN ANTIINFLAMASI GABUNGAN EKSTRAK SIDAGURI, TEMPUYUNG DAN SELEDRI PADA TIKUS
Authors: Rahminiwati Min , Jannah Raudhatul , Mohamad Kusdiantoro
Published: June 2022

Sidaguri (Sida rhombifiola L.), tempuyung (Sonchus arvensis L.), dan seledri (Apium graveolens L.) dilaporkan mengandung flavonoid yang berperan penting dalam mekanisme terjadinya efek diuretik dan antinflamasi beragam herbal. Namun potensi flavonoid dalam menimbulkan kedua efek tersebut berbeda pada setiap tanaman baik tunggal maupun ramuan. Penelitian ini ditujukan untuk mempelajari kekuatan efek diuretik dan antiinflamasi dari gabungan ketiga tanaman tersebut pada tikus. Lima ekor tikus dari masing masing kelompok uji diuretik dan 4 ekor tikus dari kelompok antiinflamasi diberi aquadest sebagai grup kontrol, ekstrak tempuyung 28 mg/200 g BB, dan kombinasi ketiga tanaman dosis 28 mg/200 g BB, 56 mg/200 g BB, dan 280 mg/200 g BB secara oral selama 8 hari berturut turut. Total volume urin kelompok tikus diuretik diukur pada hari ke 8 sampai dengan hari ke 10 sedangkan volume udem kaki tikus yang diinduksi karagenan kelompok tikus antiinflamasi diukur 30 menit sebelum dan sesudah induksi dan setiap jam selama 6 jam. Data yang diperoleh menunjukkan bahwa sediaan dosis 56 mg/kg BB mempunyai total volume urin dan percent diuretic index lebih besar dari kontrol dan pada dosis 28 mg/kg BB mempunyai nilai AUC terendah serta % DAI tertinggi. Dengan demikian sediaan. mempunyai efek antiinflamasi lebih kuat dibandingkan dengan efek diuretik.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN SALEP EKSTRAK ETANOL DAUN HARENDONG BULU (Clidemia hirta L.) TERHADAP BAKTERI Staphylococcus epidermidis
Authors: Ambarwati Rini
Published: June 2022

Bakteri Staphylococcus epidermidisdapat memperparah luka dengan menyebabkan infeksi. Infeksi yang disebabkan oleh bakteri dapat memperlama proses penyembuhan, bahkan hingga amputasi. Daun Harendong bulu (Clidemia hirta L.) mengandung senyawa metabolit sekunder yang berpotensi sebagai zat antibakteri sehingga dapat diformulasikan menjadi suatu sediaan obat seperti salep untuk dapat digunakan dalam pengobatan infeksi eksternal. Penelitian ini bertujuan untuk mendapatkan sediaan salep dari ekstrak etanol daun Harendong bulu yang memiliki mutu yang baik dan memiliki aktivitas antibakteri. Sediaan salep dibuat dalam 4 formula dengan perbedaan konsentrasi ekstrak yaitu formula 1 (9%), formula 2 (10%), formula 3 (11%), dan formula 4 (12%) kemudian dilakukan uji antibakteri terhadap bakteri Staphylococcus epidermidis menggunakan metode sumuran. Hasil penelitian yang didapatkan menunjukan bahwa salep dari masing-masing formula memiliki mutu yang baik dan aktivitas antibakteri terhadap bakteri Staphylococcus epidermidis. Formula 3 (11%) dan formula 4 (12%) memiliki aktivitas antibakteri tertinggi secara berurutan masing-masing dengan lebar daya hambat yaitu 6,287 mm dan 7,687 mm dibandingkan dengan formula 1, 2 dan kontrol positif (gentamisin sulfat 0,1%) dalam menghambat bakteri Staphylococcus epidermidis.FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN SALEP EKSTRAK ETANOL DAUN HARENDONG BULU (Clidemia hirta L.) TERHADAP BAKTERI Staphylococcus epidermidis
PENGARUH GASTROPROTEKTOR KOMBINASI TEPUNG GARUT (Marantha arundinaceae) DAN KUNYIT (Curcuma domestica Val.) PADA TIKUS MODEL TUKAK LAMBUNG
Authors: Bachri Moch. Saiful , Sofia Vivi , Khairunnisa Cipta
Published: June 2022

Tukak lambung atau lebih populer dengan penyakit maag, banyak terdapat pada masyarakat baik di Indonesia maupun di dunia. Kecenderungan masyarakat Indonesia memilih pengobatan tradisional (jamu) sejak dahulu untuk swamedikasi karena biayanya terjangkau dan efektif. Salah satunya untuk mengobati tukak lambung dinilai lebih aman dibanding dengan obat sintesis. Tukak lambung terjadi karena adanya kelebihan asam dan pepsin yang dapat disebabkan oleh stress-related mucosal damage. Tepung garut dan kunyit baik secara empiris dan ilmiah masing-masing dikatakan mampu mengurangi tukak lambung. Penelitian ini bertujuan untuk mengidentifikasi pengaruh gastroprotektor kombinasi tepung garut dan kunyit terhadap nilai indeks tukak lambung dan gambaran histopatologinya pada tikus putih galur Wistar model tukak lambung. Tikus dibagi ke dalam kelompok normal, kontrol tukak diberi etanol 96% dosis 1 ml/ 200 g/BB,kontrol positif sukralfat dosis 200 mg/kgBB, perlakuan I; II; III diberi tepung garut 200 mg/kgBB, kunyit 250 mg/kgBB,kombinasi tepung garut dan kunyit 200 mg/kgBB. Perlakuan diberikan secara oral. Pengamatan dilakukan selama tujuh hari dan diikuti dengan puasa selama 24 jam pada hari ke delapan selain kelompok normal, semua kelompok diinduksi etanol 96% dengan dosis 1 ml/200gBB. Setelah satu jam, tikus dikorbankan dan lambungnya diambil. Pengujian antiulcer dihitung dengan indeks tukak lambung dan secara deskriptif dianalisis histopatologinya. Hasil penelitian menunjukkanbahwa pemberian dosis tunggal dan kombinasi menghasilkan indeks tukak berturut-turut 1,80; 1,47; 1,33 secara nyata lebih rendah dibandingkan kontrol negatif (4,42) dan rasio proteksi (%) pemberian kombinasi tepung garut dan kunyit 200 mg/kgBB lebih tinggi dibandingkan kontrol positif. Gambaran histopatologi menunjukkan adanya perbaikan jaringan pada pemberian kunyit 250 mg/kgBB dan kombinasi tepung garut dan kunyit 200 mg/kgBB.
ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECT OF Morinda citrifolia: A META-ANALYSIS AND SYSTEMATIC REVIEW
Authors: Vashti Ervina , Fernando Oen Bernard Christoper , Yonatan Eric Ricardo , Sabatina Venna Bella , Sean Sherlyn , Rukmini Elisabeth
Published: June 2022

Morinda citrifolia (noni) is a tropical plant from the Rubiaceae family, which contains various active components that have several functions in medical fields that can act as an antioxidant and anti-inflammatory. To assess both effects, we conducted a systematic review and meta-analysis, with the PRISMA statement guidelines, to discuss the efficacy of Morinda citrifolia as an antioxidant and anti-inflammatory. The literature search was performed by searching through 12 databases: Sage Journals, ScienceDirect, Garuda, ProQuest, PubMed, Google Scholar, Web of Science, Taylor and Francis, Wiley Online Library, Cochrane Library, EBSCO, and SINTA from 2000 to 2020. From 4.605 identified record journals, we found six journals which were included in our study analysis. Our analysis showed that Morinda citrifolia has a moderate positive effect as antioxidant and anti-inflammatory agents, with an overall effect size of correlation 0.46 (CI 95% was 0.37-0.54). This study proves the potential of Morinda citrifolia as an alternative herbal medicine. Future research and studies are expected on Morinda citrifolia to investigate its further potential.
EFEKTIVITAS ANTIFUNGI MINYAK ATSIRI KENANGA (Cananga odorata) TERHADAP Aspergillus flavus
Authors: . Triastinurmiatiningsih , Haryani Tri Saptari , Wahid Ghina Athyah
Published: June 2022

Aspergillus flavus merupakan kapang penghasil utama aflatoksin yang banyak mengkontaminasi komoditi kacang-kacangan, biji-bijian, dan serealia. Bahan alami yang dapat digunakan untuk mengatasi permasalahan tersebut dengan penggunaan minyak atsiri kenanga (Cananga odorata).  Tujuan penelitian  ini adalah untuk mengetahui senyawa fitokimia dan menguji  aktivitas  antifungi dari  minyak atsiri kenanga (C. odorata) terhadap A. flavus. Penentuan Konsentrasi Hambat  Minimum  (KHM) menggunakan  metode  dilusi  padat  dengan konsentrasi  10%, 20%, 30%, dan 40%, dan  penentuan Diameter Daerah  Hambat (DDH) dengan metode  difusi  agar sumuran menggunakan lima macam perlakuan yaitu tiga konsentrasi 40%, 50%, dan 60%, kontrol positif (Ketokonazol 50 mg/L), dan kontrol negatif (Tween 80) sebanyak 50 µl. Data hasil tes DDH kemudian dianalisis menggunakan ANOVA dengan tingkat kepercayaan 95% dan α = 0,05 dilanjutkan uji Duncan. Senyawa kimia yang terkandung dalam minyak atsiri kenanga adalah flavonoid, alkaloid, saponin dan triterpenoid. Hasil konsentrasi hambat minimum didapat pada konsentrasi 40%, sedangkan pada uji DDH, konsentrasi 60% merupakan konsentrasi yang paling optimum menghambat pertumbuhan kapang A. flavus dengan rerata daerah  hambat 12,34 mm
VALIDASI DAN PENETAPAN KADAR SENYAWA RUTIN PADA EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DENGAN METODE KCKT
Authors: Handoyo Theodorus Rexa , Purnomo Go Andrew , Maryanto Chelsia Devina , Gani Michael Raharja
Published: June 2022

Binahong (Anredera cordifolia (Ten.) Steenis) merupakan salah satu tanaman herbal yang sering digunakan untuk pengobatan. Penelitian ini bertujuan untuk menetapkan kadar rutin pada ekstrak etanol daun binahong menggunakan kromatografi cair kinerja tinggi sebagai proses standardisasi ekstrak bahan alam dengan senyawa rutin sebagai penanda. Pada penelitian ini rutin digunakan sebagai senyawa penanda. Simplisia daun binahong diekstrak menggunakan metode digesti dengan etanol 96% sebagai pelarut. Ekstraksi dilakukan pada suhu 50˚C dengan kecepatan pengadukan 200 rpm, dan ekstrak dipekatkan hingga tersisa 25% volume. Ekstrak kemudian diekstraksi cair cair menggunakan pelarut n-heksan dan diambil bagian etanolnya. Analisis dilakukan menggunakan Kromatografi Cair Kinerja Tinggi (KCKT). Optimasi dilakukan menggunakan fase gerak metanol, asetonitril, air serta beberapa variasi laju alir. Dilakukan validasi menggunakan parameter selektivitas, linearitas, Limit of Detection (LOD), Limit of Quantification (LOQ), akurasi dan presisi. Komposisi fase gerak terdiri dari metanol : asetonitril : akuabides pada perbandingan 30 : 10 : 60 dengan laju alir 0,7 mL/ menit. Deteksi dilakukan pada panjang gelombang 272 nm. Hasil penelitian memenuhi parameter validasi yaitu selektivitas dengan nilai resolusi 1,676, persamaan kurva baku y = 14672x - 2408 dengan nilai r sebesar 0,9975, nilai LOD dan LOQ adalah 0,104 dan 0,316 ppm. Nilai persen perolehan kembali pada akurasi didapatkan pada rentang 90,77 – 104,47% dan presisi kurang dari 6% untuk pengujian dalam 1 hari dan hari yang berbeda. Kadar rutin yang diperoleh sebesar 0,014 ± 0,000704 mg/g ekstrak dan nilai koefisien variasi sebesar 5,17%.