bluuebunny/crossref_metadata_2025 huggingface dataset:
Ecofloristic characterization of medicinal flora of Kisantu and Mbanza-Ngungu territories, in Kongo-Central Province, DR Congo
Authors: Kembelo Pathy Kibungu , Bakwaye Flavien Nzuki , Katula Honoré Belesi , Tsimba Francois , Vanhove Wouter , Damme Patrick Van
Published: April 2023

We accessed the composition and dynamics of the vegetation in the Kisantu and Mbanza-Ngungu territories, as well as the distribution and availability of medicinal plants in their harvesting areas, using stigmatist and eco-floristic approaches. The flora was composed of 709 botanical species (113 families and 446 genera). The most abundant taxa were from Fabaceae family (14.8%), and used for medicinal purposes. Herbs (47.4%), pantropical (28.9%), phanerophytes (50.8%), species with sarcochorous diaspores (39.2%), with mesophilic leaves (49.08%) and species belonged to the Musango-Terminalietea (27.9%) group were the most dominant. The most abundant taxa were from dryland forests (45.4 ± 11.9.9) and anthropized formations (43.08 ± 11.4.4). Most species (62.04%) had a very restricted ecological niche, whereas 2.24%, had a very wide distribution. The highest similarity indices were observed, in descending order, between (1) dryland and swamp forests (KS: 70.7; JC: 26.1), (2) savannahs and dryland forests (KS: 55. 01; JC: 21.6), (3) anthropized formations and dryland forests (KS: 46.7; JC: 18.9), and (4) anthropized formations and savannahs (KS: 41.9; JC: 17.3). The Highest dissimilarity index was observed in anthropized formations (35%) and swamp forests (33%). Plant formations have a natural succession defined by vegetation dynamics from the pioneer stage to the climax stage. Field observations indicated that most habitats are degraded and that the availability of medicinal plants is decreasing. Adequate conservation measures, including in-situ and ex-situ methods are essential to promote and ensure the sustainable supply of medicinal plants to the communities that depend on these resources.
Using visual scores and categorical data for genomic prediction of complex traits in breeding programs
Authors: Azevedo Camila Ferreira , Ferrão Luis Felipe Ventorim , Benevenuto Juliana , de Resende Marcos Deon Vilela , Nascimento Moyses , Nascimento Ana Carolina Campana , Munoz Patricio R
Published: April 2023

Most genomic prediction methods are based on assumptions of normality due to their simplicity and ease of implementation. However, in plant and animal breeding, traits are often collected as categorical data, thus violating the normality assumption, which could affect the prediction of breeding values and the estimation of genetic parameters. In this study, we examined the main challenges of categorical phenotypes in genomic prediction and genetic parameter estimation using mixed models, Bayesian and machine learning methods. We evaluated these approaches using simulated and real breeding data sets. Our contribution in this study is a five-fold demonstration: (i) collecting data using an intermediate number of categories (1 to 3 and 1 to 5) is the best strategy, even considering errors associated with visual scores; (ii) Linear Mixed Models and Bayesian Linear Regression are robust to the normality violation, but marginal gains can be achieved when using Bayesian Ordinal Regression Models (BORM) and Random Forest Classification; (iii) genetic parameters are better estimated using BORM; (iv) our conclusions using simulated data are also applicable to real data in autotetraploid blueberry; and (v) a comparison of continuous and categorical phenotypes found that investing in the evaluation of 600–1000 categorical data points with low error, when it is not feasible to collect continuous phenotypes, is a strategy for improving predictive abilities. Our findings suggest the best approaches for effectively using categorical traits to explore genetic information in breeding programs and highlight the importance of investing in the training of evaluator teams and in high-quality phenotyping.
The interrelationship of childbirth-related pelvic floor injury in primiparas after vaginal delivery
Authors: Zhang Cheng , Zhao Yujiao , You Cong , Li Xiaotian , Wu Yanhong , Zhang Xiaodong , Shen Wen
Published: April 2023

Objective
This study aimed to explore the underlying relationship between the pubic bone injury and levator ani muscle injury.
Methods
150 primiparas after vaginal delivery were prospectively enrolled and divided into the pubic bone injury group and the non-pubic bone injury group according to imaging appearance on postpartum magnetic resonance imaging. The levator ani muscle morphology and function were evaluated, including injury score, H line, M line, levator plate angle, iliococcygeal angle, and levator hiatus area. The levator ani muscle morphology and function were compared between the two groups using univariate analysis. The association between the severity of the pubic bone injury and the levator ani muscle injury was calculated using the Spearman or Kendall's tau-b correlation coefficient.
Results
Compared to the non-pubic bone injury group, the pubic bone injury group more frequently complained of pelvic pain and stress incontinence (28% vs. 9.3%, P = 0.003; 29.3% vs. 13.3%, P = 0.017, respectively). The levator ani muscle morphological injury score, the H line at straining, the M line, and the levator hiatus area at rest and straining were different between the two groups (all P < 0.05). There was a positive correlation between the severity of the pubic bone injury and levator ani muscle injury score (r = 0.332), M line (r = 0.139, 0.150), and levator hiatus area (r = 0.181, 0.164) at rest and straining, respectively (all P < 0.05).
Conclusions
The pubic bone injury was a reliable reminder of morphological injury and decreased function in levator ani muscle.
A Low Layered Deep Network Model for the Classification of Skin Dermoscopy Images
Authors: AMBIKA M , RAO P. TRINATHA
Published: April 2023

One of the deadliest forms of skin cancer is Melanoma. This is increasing gradually, especially in males and can be treated if diagnosed at early stages. Manual inspection involves critical inspection by dermatologists and the decision requires a lot of expertise and consumes lot of time, hence there is a need to develop automated lesion detection and classification system with image processing and deep learning methods. There are several image processing methods were proposed in the research however there is a scope to automate the entire with deep learning methods. This paper proposes low layered, high performance deep network architecture for the classification of skin lesion images and evaluates the performance of the network with standard datasets. The work also focuses on comparing the performance evaluation metrics against state of art networks and highlights the need for new customized networks.
Acculturating to Multiculturalism: A New Dimension of Dietary Acculturation among Asian American, Native Hawaiian, and Pacific Islander Women in the San Francisco Bay Area, USA
Authors: Tan Judy , Guan Alice , Albers Autumn E. , Canchola Alison J. , Allen Laura , Shariff-Marco Salma , Gomez Scarlett Lin
Published: April 2023

Dietary acculturation is the process by which diet and dietary practises prevalent in a new environment are adopted and/or those from the environment of origin are retained or changed. Knowledge gaps exist on chracterising dietary acculturation among Asian American, Native Hawaiian, and Pacific Islander communities (AANHPI), despite rapid population growth the USA. This study characterise dietary patterns in a sample representative of AANHPI on key demographic characteristics. Data were from a 2013–2014 population-based case-control study in the San Francisco Bay Area, U.S. Survey items were adapted from dietary acculturation scales developed for Chinese, Filipinx, Vietnamese, Japanese, Korean, and Asian Indian and Pakistani populations. Validated measures assessed social networks, social standing, discrimination and immigration experiences. A principle components factor analysis characterise dietary patterns of acculturation. Three dietary patterns were identified: “Asian,” “Western,” and a distinct “Multicultural” factor. Respondents reporting a high-Asian diet tended to also report smaller social networks, higher levels of stress, and, among those born outside of the U.S., an educational standing that was better before immigration. Respondents who ate a high-Western diet tended to also report the highest level of discrimination. Those reporting a high-Multicultural diet tended to report higher neighbourhood collective efficacy. The finding of a distinct “Multicultural” factor beyond the typical “Asian” and “Western” factors may reflect the multidirectional nature of dietary acculturation, in which origin and destination cultures interact in complex ways and where foods from multiple ethnicities intermix.
Dual Double Point Cloud Transformer
Authors: Zhong Qi , Han Xian-Feng , Fang Cheng-Yu , Yang Lu
Published: April 2023

Long-range context relationship plays an important role in understanding point clouds. Inspired by the permutation invariance of the recent Transformer models, in this paper, we propose an end-to-end Dual Double Transformer (DDTFormer) architecture for 3D point cloud processing. Specifically, two core components, termed point-wise double transformer and channel-wise double transformer blocks, are well designed for explicitly modeling interdependencies among points and channels. And both blocks consist of two key operations: aggregation attention mapping the point-wise/channel-wise feature maps into a global space, and propagation attention diffusing the aggregated features back to the input points or channels. We illustrate the effectiveness and competitiveness via extensive quantitative and qualitative experiments on 3D shape classification and segmentation benchmark datasets.
Navitoclax mediates Interleukin-3 induced human umbilical vein endothelial cells survival and angiogenesis
Authors: Hisam Nur Syahidah Nor , Ugusman Azizah , Rajab Nor Fadilah , Gregoli Karina Di , Ahmad Mohd Faizal , Anuar Nur Najmi Mohamad
Published: April 2023

Navitoclax is an effective pro-apoptotic agent against cancer cells. Uncontrolled cell survival is a hallmark of pathological angiogenesis in cancer and could promote plaque instability that contributes to atherosclerosis progression owing to intraplaque neovascularization. Cancer cell inhibition by navitoclax can restrain metastasis; therefore, it is possible to reduce endothelial cells survival and is expected to confer a novel therapeutic strategy for advanced atherosclerosis in regards to plaque instability. However, regulation of endothelial cell activity by navitoclax is yet to be examined. This study will analyze navitoclax efficacy in modulating human umbilical vein endothelial cells (HUVEC) viability, proliferation, migration and angiogenesis. Navitoclax concentrations ranging from 0.2 to 3.0µM at four-time points; 18-, 24-, 48- and 72-hours were used for MTT assay. The IC50 value for 18-hours post-treatment was undefined due to low efficacy at a limited time. While for 24-, 48- and 72-hours, the IC50 values were 0.91µM, 0.72µM, and 0.12µM, respectively. Navitoclax potency to inhibit HUVEC viability increased as the treatment time elevated. 0.9µM navitoclax for 24 hours treatment was selected for subsequent experiments. Next, 25 ng/ml IL-3 was used to induce the in-vitro angiogenesis model within 6 hours. Expectedly, navitoclax reduced the tube formation and migration of HUVEC induced by IL-3 in consistent with CXCL-8 released and MMP-3 expression in the cell. However, HUVEC proliferative activity was not affected by navitoclax treatment, as well as the BCL-2 gene expression. Therefore, an anti-angiogenic effect of navitoclax on HUVEC by preventing the cell motility through CXCL-8 and MMP-3 mechanism is determined.
Exact travelling wave solutions of time-fractional Clannish Random Walker's Parabolic equation and sensitive analysis
Authors: Asjad Muhammad Imran , Ashaq Hira , Faridi Waqas Ali , Majid Sheikh Zain
Published: April 2023

In this article, the new extended direct algebraic method is used to build the exact travellingwave solutions for the non-linear time-fractional Clannish Random Walker’s Parabolic equation.This study establishes the framework in which periodic, singular, dark, bright and kink-typewave solitons are obtained with exact solutions offered by the mixed hyperbolic and trigonom-etry solutions, mixed periodic and periodic solutions, plane solutions, shock solutions, mixedtrigonometric solutions, mixed singular solutions, mixed shock single solutions, complex solitarysingular solutions, shock solutions and shock wave solutions. The exact soliton solutions of thetime-fractional clannish random walker’s parabolic equation model is graphically presented atdifferent values of involved parameters by Wolfram Mathematica software. The propagating behaviours display in 3-D, contour and 2-D surfaces of the obtained results to visualise the im-pact of the involved parameters. The sensitivity analysis is demonstrated for the wave profilesof the designed dynamical framed structure, where the soliton wave number parameter regulatesthe water wave singularity. This analysis illustrates that the utilized method is efficient andreliable and can be useful to find appropriate solutions in closed-form solitary soliton to a wide range of non-linear evolution equations. These techniques can also be utilised to find new exact travelling wave solutions for any class of integer or fractional differential equations thatarise in mathematical physics.
A Case of Nocardiosis in a Patient with Ulcerative Colitis on Chronic Corticosteroids and Treated with Upadacitinib
Authors: Moy Benjamin M. , Shenoy Abhishek , Aldrich Leslie B.
Published: April 2023

The immunosuppressive effects of treatment for ulcerative colitis, including chronic corticosteroids, anti-TNF agents, and JAK inhibitors, can impact the spread of latent or obscure infections. Clinicians should have low thresholds for aggressive diagnostic and therapeutic intervention if patients show signs of clinical deterioration while on upadacitinib. Our unique case highlights an immunosuppressed patient with ulcerative colitis who developed Nocardiosis after initiation of upadacitinib while hospitalized for concurrent UC flare and C. difficile infection.
The Role of Political Stability in the Context of ESG Models at World Level
Authors: Costantiello Alberto , Leogrande Angelo
Published: April 2023

In this article, we estimate the role of Political Stability and Absence of Violence and Terrorism-PS in the context of Environmental, Social and Governance-ESG data at world level. We analyse data from 193 countries in the period 2011-2020. We apply Panel Data with Fixed Effects, Panel Data with Random Effects and Pooled Ordinary Least Square-OLS. We found that PS is positively associated, among others, to Population Density and Government Effectiveness, and negatively associated, among others, to Research and Development Expenditure and Maximum 5-day Rainfall. Furthermore, we apply the k-Means algorithm optimized with the application of the Elbow Method and we find the presence of four clusters. Finally, we propose a confrontation among eight different machine-learning algorithms for the prediction of PS and we find that the Polynomial Regression shows the higher performance. The Polynomial Regression predicts an increase in the level of PS of 0.25% on average for the analysed countries.
JEL Codes: D7, D70, D72, D73, D78.
A Pan-cancer Analysis of Ferroptosis-related Gene Arachidonic Acid 15-Lipoxygenase-1 (ALOX15): Its Prognostic and Immunotherapeutic Values
Authors: Yang Hua
Published: April 2023

The recent researches identify ferroptosis is an entirely new form of programmed cell death. Arachidonic acid 15-lipoxygenase-1 (ALOX15) is a key gene that mediates this process. However, the role of ALOX15 in human tumors is not clear. We conducted a pan-cancer analysis to explore the role and significance of ALOX15 in pan-cancer using multiple databases, we found the transcription and protein expression of ALOX15 were significantly reduced in HNSC, LUAD, LUSC, SKCM, KICH and THCA, were significantly up-regulated in ESCA, LIHC, PRAD and UCEC, Expression of ALOX15 had prognostic value for certain cancers such as LUAD, LUSC, LIHC, KIRC, HNSC, THCA and LGG. ALOX15 expression was also markedly correlated with the clinical characteristics, immune cell infiltration, ICKs, genomic instability and antitumor drug sensitivity of different tumors. Gene mutation of ALOX15 and prognostic value of mutation was found in pan-cancers. Moreover, GO/KEGG analysis and single-cell transcriptome sequencing showed that ALOX15 was significantly associated with cancer-related pathways. The results suggested ALOX15 might serve as a prognostic and immunotherapeutic marker for pan-cancer, might provide new direction and evidence for cancer therapy.
Ricci soliton on a class of Riemannian manifolds under D-isometric deformation.
Authors: AdelDelloum  , Beldjilali Gherici
Published: April 2023

In this article, we investigate the behavior of Ricci solitons under D-isometric deformations on a class of Riemannian manifolds. A D-isometry is a diffeomorphism that preserves the distance function induced by a Riemannian metric up to a constant factor. We consider a family of Riemannian metrics g on a manifold M that are related by D-isometric deformations, and we study the Ricci soliton equation on each metric g. We show that under certain conditions on the deformation function, the solutions to the Ricci-Soliton equation on each metric g are invariant. In particular, we obtain a family of Ricci-Solitons that are related by a scaling factor under D-isometric deformations. We also provide explicit examples of D-isometric deformations and compute the corresponding Ricci-Solitons.
2000 Mathematics Subject Classification. 53C15, 53C25, 53D10.
Predictive modeling of ischemic stroke, identification of relevant subgroups, and drug prediction based on multiple programmed cell death patterns
Authors: Yang Huifeng , Shen Jing , Lu Minyan , Feng Yu
Published: April 2023

Background: Ischemic stroke is the second leading cause of mortality and disability globally. Along with many immune and disease conditions, Programmed cell death (PCD) also has a critical role in ischemic stroke and may serve as a diagnostic indicator of ischemic stroke.
Methods: From the Gene Expression Omnibus database (GEO), two ischemic stroke datasets were chosen, one for training and the other for the validation group. From the KEGG and other databases, 12 patterns of PCD-related genes were selected. Differentially expressed genes (DEG) were found using Limma analysis; functional enrichment analysis;machine learning least absolute shrinkage and selection operator (LASSO) regression; candidate immune-related central genes were identified using Random Forest along with the construction of a protein-protein interaction network (PPI) and an artificial neural network (ANN) for validation. In order to diagnose an ischemic stroke, the Receiver operating characteristic (ROC) curve was plotted, the diagnostic model was validated by qRT-PCR, immune cell infiltration was investigated to observe immune cell dysregulation in ischemic stroke, and the expression of candidate models under different isoforms was analyzed by consensus clustering (CC). Finally, drugs associated with candidate genes were collected through the Networkanalyst online platform.
Results: A total of 71 genes were shown to be the crossover of DEG and PCD-related genes in ischemic stroke, and six candidate genes were finally identified by machine learning to establish a diagnostic prediction model. After using an artificial neural network (ANN) for validation, ROC curve plotting, and qRT-PCR validation for diagnostic value assessment. The outcomes demonstrated that the prediction model had a high diagnostic value. In the immune infiltration analysis, significant variability of NKT was found in ischemic stroke patients. Seven drugs associated with candidate genes were collected from the Networkanalyst online platform.
Conclusion: A diagnostic prediction model with a good effect in the training group and validation group (AUC 0.94, CI 1.00-0.88 and AUC 0.91, CI 0.97-0.86, respectively), along with a good phenotype in qRT-PCR validation by comprehensive analysis was obtained. Additionally, the drugs (C646 substance, Cyclosporine, Decitabine, Dexamethasone, Resveratrol, Silicon Dioxide, and Tretinoin) that might be useful in the treatment of ischemic stroke were obtained.
The resistance of quantum entanglement to temperature in the Kugel-Khomskii model
Authors: Valiulin Valerii E. , Mikheyenkov Andrey V. , Chtchelkatchev Nikolai M. , Kugel Kliment I.
Published: April 2023

The Kugel–Khomskii model with entangled spin and orbital degrees of freedom is a good testing ground for many important features in quantum information processing, such as robust gaps in the entanglement spectra. Here, we demonstrate that the entanglement can be also robust under effect of temperature within a wide range of parameters. It is shown, in particular, that the temperature dependence of entanglement often exhibits a nonmonotonic behavior. Namely, there turn out to be ranges of the model parameters, where entanglement is absent at zero temperature, but then, with an increase in temperature, it appears, passes through a maximum, and again vanishes.
Mechanical behavior of a highway tunnel under the influence of lining crack disease
Authors: Zhao Dongkui , Quan Xiaojuan , Zhou Huan , Sun Wenchang , Huang Yiwen , Jiang Nan
Published: April 2023

Highway tunnels built in China in the early years of operation have different forms of diseases, which have a great impact and threat to the normal operation and safety of the tunnel. To ensure the safety and stability of the lining structure, this paper analyzes the mechanical behavior of the lining structure under the influence of the disease and reveals the evolution law of the lining crack disease for typical tunnel lining cracks. The results of the study show that only the circumferential and longitudinal stresses at the vault increase when cracks exist in the inner wall of the lining vault. The longitudinal cracks in the inner wall of the lining have the greatest influence on the lining stress state.
Research and design of program complexity measurement technology based on OINK framework
Authors: Qiao Liping , Zou Xuejun , Duan Rui , Jia Xueting
Published: April 2023

With the expansion of software system scale, the study of software complexity has become a hot topic in software engineering. However, the domestic research on software complexity analysis technology is not mature, especially the measurement and evaluation methods of software complexity are not perfect. In order to solve the problem of prediction and evaluation of program structure complexity in software engineering more effectively, this paper proposed a program complexity measurement technique based on OINK framework. The technology uses the data sharing interface design to analysis target program by extracting the complex relationship between OINK components. On this basis, the technology adopts the layered software architecture to realize the automatic design of the function of the measurement data acquisition module, the complexity measurement module and the data management module of measurement results, thus, the structure complexity of the target program can be analyzed more clearly and accurately. At the same time, this technique applies multiple measurement methods to quantify the complexity of program structure, such as McCabe, HalStead, and Line Count. Experimental results show that this method can effectively measure the complexity of program structure. The solution on software complexity based on the open source ONIK framework will be open up worldwide, and will be continuously supported and improved by global communities and teams under the constraints of common driving forces.
Effects of triticale flour on the quality of honey cookies
Authors: Kandrokov Roman
Published: April 2023

Flour confectionery products are highly popular in Russia, especially honey cookies (pryanik). In order to increase their nutritional value, wheat flour can be replaced by triticale flour rich in essential amino acids and minerals. This study aimed to determine the effects of triticale flour on the quality of honey cookies.

The control cookie sample was made from premium wheat flour, while the test samples were made from mixtures of wheat and triticale flours in various ratios (10–90%), as well as from 100% triticale flour of grade T-80. Standard methods were applied to determine the cookies’ sensory and physicochemical characteristics, as well as their nutritional value and contents of minerals, vitamins, and amino acids.

All the samples with triticale flour showed good sensory characteristics. Adding up to 30% of triticale flour did not change the taste and aroma of honey cookies, whereas larger amounts of triticale flour made them sweeter and more aromatic. The test samples from 100% of triticale flour had higher contents of essential amino acids (arginine, valine, histidine, isoleucine, leucine, lysine, methionine, and threonine) than the control sample from premium wheat flour. The contents of micro- and macroelements also increased with larger amounts of triticale flour in the formulation. While adding triticale flour increased the protein content in the test honey cookies, it had no significant effect on their fat and carbohydrate contents, or the calorie content. The tests showed that 60:40% was the optimal ratio of wheat and triticale flours.

Replacing wheat flour with 40% of triticale flour provided the finished product with good sensory properties and high contents of proteins, vitamins, essential amino acids, as well as micro- and macroelements. Thus, triticale flour proved to be a good replacement for wheat flour in the production of honey cookies.
Improving the Local Self-Government’s Image Based on the Analysis of Internet Marketing Communication Tools on the Example of the Kemerovo Municipality
Authors: Shadrin Vladislav , Kotova Olga , Zavyalova Ekaterina
Published: April 2023

Different communication channels used by the state have their own weaknesses and strengths. In order to identify specific problems in communication with citizens and to improve the image of local self-government, it is necessary to study the opinion of citizens in detail. The subject of the article is the image of local self-government bodies. The purpose is to analyze the image of the Kemerovo City local government, identify relevant problems, and develop measures to improve it. The study analyzes the official websites and social networks of the heads and administrative bodies of the Kemerovo City as well as citizens’ perception of their image. The authors use the survey method to assess the image of the city and study the tonality of its mentions in media and comments in unofficial communities of the region. The problems that negatively impact the effort to improve the image of municipal administrations were identified. In general, the perception of the municipality administration is neutral, but when a particular topic is relevant to a user, they might become more demanding and information-negative towards the administration. It was revealed that residents lack information campaigns and feedback on a number of issues.
Teaching of Biology Supported by Mathematical Models
Authors: Uchmański Janusz , Maciejewska Joanna
Published: April 2023

In the life sciences, the use of mathematical modelling and computer simulation methods has brought many benefits. This is the case, for example, in physics. Biology makes very little use of these methods. One of the reasons for this may be that the biology teaching process is conducted in such a way that it discourages young people with an interest in mathematics and computer science. We propose to support the process of teaching biology by introducing simple elements of mathematical modelling of ecological processes. In this work, we showed what benefits would be the application of the NetLogo program in teaching biology in secondary schools. NetLogo is a multi-agent programming language designed to simulate complex phenomena. It is intended for both research and education and is used in a wide variety of scientific disciplines. We used the NetLogo program to create a model of searching for food by ants. We have shown that teaching biology by building a computer model forces a deeper understanding of the problem we are working on and uses and develops the creative abilities of young people.
CAR Selectively Enhances the Pulmonary Vasodilatory Effect of Fasudil in a Microsphere Model of Pulmonary Hypertension
Authors: Rothman Abraham , Restrepo Humberto , Evans William N. , Sarukhanov Valeri , Mann David
Published: April 2023

Background:

Despite the approval of several medications for pulmonary hypertension, morbidity and mortality are unacceptably high. Systemic hypotension may limit the use of pulmonary hypertension medications.

Objectives:

This study aimed to assess whether the homing peptide CAR (CARSKNKDC) improves the vasodilatory selectivity of fasudil in the pulmonary circulation or systemic circulation in a porcine pulmonary hypertension model.

Materials and Methods:

Pulmonary hypertension (to approximately 2/3-3/4 systemic pressure levels) was induced by chronic and acute administration of microspheres in 3 micro Yucatan pigs (mean weight 19.9 kg, mean age 4.3 months). Fasudil (0.3 mg/kg) was administered without and with CAR (1.5 mg/kg), and the effect on aortic (Ao) and right ventricular (RV) pressure was recorded with indwelling catheters.

Results:

Immediately after fasudil administration, there was a decrease in Ao pressure followed by prompt recovery to baseline. The RV pressure decrease was progressive and sustained. Fasudil alone resulted in a 12% decrease in RV pressure, whereas co-administration of CAR with fasudil resulted in a 22% decrease in RV pressure (p < 0.0001). Fasudil alone caused an average decrease of 34% in the RV/Ao pressure ratio, and fasudil + CAR caused an average decrease of 40% in the RV/Ao pressure ratio (p < 0.0001).

Conclusion:

The homing peptide CAR selectively enhanced the acute vasodilatory effects of fasudil on the pulmonary vascular bed in a porcine experimental model of pulmonary hypertension.
Educação e o sistema prisional: Percepção das mulheres privadas de liberdade
Authors: Tiellet Maria do Horto Salles , Araújo da Silva Ana Luiza de
Published: April 2023

O objetivo deste artigo é dar destaque à percepção das mulheres da Unidade Prisional Feminina de Cáceres-MT/BR sobre a educação, e a questão a ser respondida é: qual a percepção que as mulheres privadas de liberdade na cadeia feminina de Cáceres têm sobre a educação, especialmente a prisional? O estudo é descritivo, do tipo Estudo de Caso e de abordagem qualitativa. O local da investigação foi a Unidade Prisional de Cáceres-MT/BR. As informações foram coletadas em entrevista com cinco mulheres selecionadas através dos seguintes critérios: condenadas; residentes em Cáceres; mães com filhos em idade escolar e envolvidas nas atividades escolares na Unidade Prisional. Utilizou-se a técnica de Análise de Conteúdo de Laurence Bardin (1977), aplicada à sistematização dos dados da entrevista, organizados segundo os eixos temáticos: Delito, Sistema Prisional, Família dos quais foram extraídos fragmentos relacionados à unidade de registro:   educação. Um dos resultados do estudo mostra que as mulheres privadas de liberdade manifestam esperança e interesse pela educação (escolarização e/ou cursos profissionalizantes), não somente voltada à remição, mas como instrumento para a melhoria das suas condições de vida ao retornarem à sociedade.
Разложение CO-=SUB=-2-=/SUB=- в барьерном разряде в присутствии церийоксидных катализаторов
Authors: Лебедев Ю.А. , Голубев О.В. , Батукаев Т.С. , Максимов А.Л.
Published: April 2023

A number of catalysts based on cerium oxide have been synthesized to study the process of plasma-catalytic decomposition of CO2 in a barrier discharge. For the first time, an oxide catalyst MgCe–Al has been compared with samples containing only cerium oxide or magnesium oxide in the composition. It has been established that in the presence of the MgCe–Al sample, the highest degree of CO2 decomposition and energy efficiency are achieved.
Электротермооптические характеристики и предельные энергетические возможности мощных AlGaN-светодиодов глубокого ультрафиолетового диапазона (λ~ 270 nm)
Authors: Закгейм А.Л. , Иванов А.Е. , Черняков А.Е.
Published: April 2023

The current and temperature dependences of the electrical, power and spectral characteristics of high-power deep UV LEDs (λ≈ 270 nm) have been studied. The main parameters of LED (internal quantum efficiency and light extraction efficiency) which determine output power capacity of the UV LED are calculated using the ABC-model. The influence of current distribution, electrical losses and thermal resistance as factors limiting the energy possibilities were estimated.
Упругое рассеяние атома рутения на атомах Si и O в диапазоне относительных кинетических энергий 2-200 eV
Authors: Палов А.П.
Published: April 2023

Interconnector technologies of a new generation involve use of ruthenium. The high cost of experimental study of sputtering and etching of trenches in Ru leads to the need to optimize it by modeling, requiring knowledge of the cross sections of elementary processes of interaction of plasma particles with Ru. In this work, the binary interatomic potentials of Ru-Ru and Ru-Si pairs, tested by molecular dynamics method, and the Ru-O one calculated using the multi reference configurational interaction MRCI/AV5Z were used to calculate the elastic scattering cross sections of the atomic pairs in the energy range typical for plasma etching chambers.
Нарушение соответствия тока индукции и тока эмиссии при пироэлектрическом эффекте в монокристалле танталата лития в условиях вакуума
Authors: Олейник А.Н. , Гильц М.Э. , Каратаев П.В. , Кленин А.А. , Кубанкин А.С. , Шаповалов П.Г.
Published: April 2023

A comparison of the induction current and the emission current during the pyroelectric effect in vacuum conditions with periodic variation in the temperature of a single crystal of lithium tantalate is presented. An increase in the variation frequency leads to suppression of the emission current, which does not allow one to observe the effect of the optimal frequency with the maximum amplitude, as for the induction current. The conformity of both current forms is shown, except for the region of 2 mHz or less, where an additional current wave is observed. It is established that this additional wave is initiated above a certain threshold of potential difference and leads to its stabilization.
Радиационно-стойкие градиентные многомодовые волоконные световоды на основе фторсиликатного стекла
Authors: Поспелова Е.А. , Кашайкин П.Ф. , Мальцев И.А. , Вохмянина О.Л. , Шаронова Ю.О. , Азанова И.С. , Томашук А.Л.
Published: April 2023

Using MCVD-technology, radiation-resistant multimode optical fibers based on fluorosilicate glass with a gradient refractive index profile were developed. Radiation-induced attenuation of light (RIA) in the fibers was compared with the literature data on analoguous fibers manufactured by the PCVD-technoogy. It was found out that RIA in the MCVD-fibers at the wavelength λ=1310 nm under γ-irradiation at doses of up to 10 kGy is 1-2 dB/km (19%-29%) lower than RIA in Super RadHard fiber produced by the PCVD-technology and previously supposed to have record-high radiation resistance.
Clinical сase of disorder of sex development with karyotype 47XYY
Authors: Shaydullina M. R. , Akramov N. R. , Valeeva F. V. , Alimetova Z. R. , Kolbasina E. V.
Published: April 2023

Disorder of sex development (DSD) is a term used to refer to congenital disorders that led to atypical structure of the genitals. The cause of DSD is a disorder of the embryonic development of the reproductive system due to chromosomal, genetic pathology or other adverse effects on pregnancy. DSD entails difficulties with social adaptation of the family, leads to severe psychological disorders in the child and his relatives. Sex of a child with DSD should be established only after a full examination and consultation of specialists in this field. A clinical case is presented to illustrate the complexity of differential diagnosis and choice of passport sex in a child with one of the rare forms of DSD.
Regional Growth, Debt Thresholds and Subnational Sustainability
Authors: Mendoza-Velázquez Alfonso , J. Smith Heidi , Mendoza-Martínez Diego
Published: April 2023

Aim: To examine the nexus between subnational debt sustainability and regional economic growth. Method: The study employs dynamic panels by Arellano-Bond and the kink model to estimate debt thresholds by Seo and Shin. Results: The study finds a positive association between subnational debt and regional GDP growth, which differs by type of debt. The fiscal intergovernmental architecture of federal system in Mexico results in lower debt thresholds compared to national thresholds. Recommendations: Fiscal, regulatory and normative rules on bank debt should aim to provide the right incentives to encourage regional growth. Limitations: Results from a small sample are a first approximation to the regional debt-growth nexus in Mexico. The lack of updated and consistent data for longer horizons on subnational public finance limits the generalization of the findings. Originality: The study helps to understand the effect of increasing debt on regional GDP growth in centralized fiscal systems and the differential effect by type of financing. Conclusions: Highly centrally regulated fiscal models with limited revenue autonomy could engender soft budget problems and create financial management inefficiencies.
Estrategias de crecimiento económico en México y Corea del Sur, un análisis comparativo
Authors: Lara Maldonado Marisol , Vásquez Galán Belem , Calderón Villarreal Cuauhtémoc
Published: April 2023

El objetivo del artículo es medir y comparar como la formación bruta de capital fijo, la educación terciaria y el comercio internacional han determinado el crecimiento económico de México y Corea del Sur. Mediante la estimación de un modelo VEC se identificaron las relaciones de largo y corto plazo entre las variables (periodo 1994 a 2018). Los resultados indican que el crecimiento de Corea del Sur estuvo determinado por la formación bruta de capital y la educación terciaria como lo afirma la teoría del crecimiento endógeno; mientras que la economía mexicana mantuvo un lento crecimiento, consecuencia de los problemas que tuvo el proceso de formación de capital. Una limitante es la dificultad para medir la participación del Estado en el proceso de crecimiento. La originalidad del estudio radica en identificar efectos de corto y largo plazo, asi como la inclusión de variables de orden interno y externo. Se concluye que la respuesta del crecimiento económico es positiva y sostenida en países con mayor acumulación de capital y calidad de la mano de obra, donde la participación del estado es clave.
Techno-Economic Analysis of Waste-to-Suburban Cooking Energy Critical Infrastructure Development in Southwestern Nigeria
Authors: OGUNDARI Ibikunle Olalekan
Published: April 2023

This study examined the techno-economic specifications for a Waste-to-Suburban Cooking Energy critical infrastructure project in Southwestern Nigeria. Technological and project economic data for the W2E project were obtained from strategic sources and energy project foresight/analysis framework used. The results showed residential upgraded biogas-for-cooking demand of approximately 10,243 m3/month, and municipal solid waste (MSW) input of approximately 80 tonnes/month. The planned biogas plant had estimated costs of US $120,000, a throughput of almost 15,364 m3/month and required 5 acres of land for construction. Project economic viability indicator estimates were: Initial Investment – US $256,500, annual profits – US $40,000, Net Present Value (NPV) – US $142,000, maximum payback period – 7 years, and annual Return-on-Investment (ROI) – 16%. Socio-economic benefits per month included the constant supply of cheap cooking fuel, comparative cooking energy cost savings (biogas-to-LPG usage) of US $3,810, and the elimination of almost 80 tonnes of MSW from the environment. The study concluded that the Waste-2-Biogas critical infrastructure project was technically, environmentally, and socio-economically viable, and was suitable for deployment across suburban Southwestern Nigeria.
Heifers and multiparous cows are affected by Dystocia and its implications on the viability of the pregnancy
Authors: Yousif Mahmood Mohammad , Yaseen Khudhair Nooruldeen , Mahmood Rasheed Yaseen
Published: April 2023

Dystocia considers one of the most common obstetrical problems in cattle, especially in heifers; the current study achieved to demonstrate Dystocia's impact on the viability of the fetus in heifers and cows. The study involved 15 multiparous cows aged 3-7 years and 10 heifers; these animals suffered abnormality calving. The study showed Dystocia higher significantly (P≤0.01) in 15 (60%) multiparous cows than 10 (40%) heifers; also, the rate of difficult male birth was greater 7 (70%) than in difficult female birth were 3 (30%) in heifer animals. Heifer had difficult male birth with the anterior presentation of the fetus was 5 (71.42%), higher than with posterior presentation fetus 2 (28.58%). One heifer cow (20%) had difficult male birth with flexion of the elbow joint in the anterior presentation alive fetus, whilst the heifer cows had difficult male birth with flexion of the elbow joint dead fetus were 2 (40%) with significant difference towards dead fetus at(P≤0.01). The number of heifers that had a problematic female birth with anterior presentation and flexion of the shoulder joint of an alive fetus was 1 (33.34%).

In contrast, one heifer (33.33%) with a transverse presentation of a female dead fetus and one heifer (33.33%) had difficult female birth with posterior presentation and incomplete extension of hind limbs alive fetuses with a significant difference towards dead fetuses at (P≤0.05). The number of multiparous cows that had difficult male births was 8 (53.34%), and those that had difficult female births were (7) (46.66%). The multiparous cows have difficult male births with anterior and flexion of elbow joints, with a down deviation of head alive fetuses and back head, live fetuses were (37.5%), (12.5%) and (12.5%) respectively, with significant differences among these categories towards alive fetuses at (P≤0.01). The number of multiparous cows had difficult female birth with anterior presentation alive fetus, and uterine inertia was 1 (14.28%), whereas the multiparous cows had difficult female birth with anterior presentation and down deviation of fetus's head was 4 (57.14%) (3 alive fetus+1dead fetuses). With a significant difference among these categories towards live fetuses at (P≤0.01). The study concluded that Dystocia is a severe joint event in cows; the flexion of the elbow joint and head-down deviation in the anterior presentation of the fetus are common types of Dystocia, whilst the more common types of Dystocia are an incomplete extension of hind limbs in the birth canal in the posterior presentation, with variable effects of these types of Dystocia on fetal viability.

Keywords: Calving abnormality, Dystocia, Fetal viability, Dairy cows
Analisis terhadap Kinerja Instalasi Pengolahan Air Limbah (IPAL) pada Industri Gudeg Kaleng di PT XYZ, Yogyakarta
Authors: Apriliyani Ima , Ainuri Makhmudun , Suyantohadi Atris
Published: April 2023

Industri Pengalengan Guded di PT. RD, Yogyakarta memproduksi Produk Gudeg Kaleng untuk dipasarkan baik didalam negeri dan keluar negeri.  Pada unit Pengolahan air limbah (IPAL) PT RD setelah dilakukan pengujian nilai pH, BOD5, COD, TSS, dan suhu efluen IPAL menunjukkan ketidak sesuaian nilai berdasarkan Peraturan Daerah Istimewa Yogyakarta Nomor 7 Tahun 2016.  Penelitian ini bertujuan untuk melakukan analisis kinerja pada unit IPAL PT RD terhadap parameter pH, BOD, dan COD dan usulan perbaikan terhadap Kinerja IPALnya agar  dapat beroperasi menghasilkan efluen yang sesuai dengan baku mutu yang dipersyaratkan pemerintah. Metoda penelitian dalam analisa kinerja IPAL dilakukan menggunakan Analisis Dimensi berdasarkan data-data perhitungan secara kuantitatif dan deskriptif. Dari analisa kinerja IPAL didapatkan factor penyebab ketidaksesuainya kinerja IPAL disebabkan 1) ukuran saringan yang kurang sesuai yaitu 39 cm×100 cm, 2) kondisi scum yang kotor tidak dibersihkan. 3) bak pengolahan anaerob yang digunakan hanya dapat mengolah beban COD 6,32 kg COD/m3.hari dan beban BOD5 1,51 kg BOD5/m3.hari sedangkan beban COD yang harus diolah melebihi kapasitas yang besarnya 6,74 kg COD/m3.hari dan beban BOD 1,71 kg BOD5/m3.hari, 4) penggunaan bakteri yang tidak sesuai dengan jenis pengolahan dan 5) tidak adanya  proses netralisasi. Usulan perbaikan berdasarkan analisa kinerja IPAL yang diteliti;  1) penggantian saringan dengan ukuran yang sesuai yaitu 39 cm×110 cm; 2) pembersihan scum dan penambahan koagulan; 3) penggunaan teknologi biofilter anaerob dengan waktu tinggal 32,71 jam, organic loading rate 7,85 kg COD/m3.hari, hydraulic loading rate 0,0036 m3/m2.jam, pemasangan bioball dari material PVC, berbentuk bola, diameter 3 cm, luas kontak spesifik 200-240 m2/m3, porositas rongga 0,92, berwarna hitam dan volume 0,94 m3, pemasangan pipa dengan panjang 50-60 cm; 4) penggunaan Bakteri Nutrabact Anaerob dengan dosis pemakaian pertama 90-230 ml dan pemakaian harian 47 ml yang dibagi rata ke tujuh kolom biofilter; 5) netralisasi dengan membuka kedua bak kontrol dan penambahan kapur, serta pengontrolan efluen.
Review on Ethnomedicinal and Potential Effect of Antibacterial Plants against Halitosis
Authors: Kintoko Kintoko , Desmayanti Astri
Published: April 2023

Halitosis is an oral malodor condition in the oral cavity that comes from the breakdown of protein by anaerobic gram-negative and gram-positive bacteria. Some bacteria that are often found in cases of halitosis are Solobacterium moorei, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia, Treponema denticola, dan Streptococcus mutans. Medicinal plants to treat various diseases have shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. As many as 7,000 species of medicinal plants in Indonesia have been studied to address health problems. Among the medicinal plants that have been studied are Green Betel (Piper betle L.), Cinnamon (Cinnamomum zeylanicum), Star Anise (Illicium verum), Mint (Mentha piperita) dan Oregano (Origanum vulgare) which have been shown to cure various diseases. This review article describes the potential of plants as an antibacterial against halitosis. The purpose of this review is to provide an overview of ethnomedicine and the potential effects of antibacterial medicinal plants that can be used in cases of halitosis.