bluuebunny/crossref_metadata_2025 huggingface dataset:
TNFα priming through its interaction with TNFR2 enhances Endothelial Progenitor Cell immunosuppressive effect: a new hope for their widespread clinical application
Authors: BARKESTANI Mahsa NOURI , SHAMDANI Sara , BAKSHLOO Mazdak AFSHAR , AROUCHE Nassim , BAMBAI Bijan , UZAN Georges , NASERIAN Sina
Published: September 2020

Background
Bone marrow derived endothelial progenitor cells (EPCs) are immature endothelial cells (ECs) involved in neo-angiogenesis and endothelial homeostasis and are considered as a circulating reservoir for endothelial repair. Many studies showed that EPCs from patients with hematological and cardiovascular pathologies are impaired and insufficient; hence, allogenic sources from adult or cord blood are considered as good options for cell therapy applications. However, allogenic condition increases the chance of immune rejection, especially by T cells, before exerting the desired regenerative functions. TNFα is one of the main mediators of EPC activation that recognizes two distinct receptors. TNFR1 has ubiquitous expression and its interaction with TNFα leads to deleterious effects and apoptosis, whereas, TNFR2 is expressed on few cell types and is involved in protective and survival mechanisms. We have recently reported that human EPCs are immunosuppressive and this effect was TNFα-TNFR2 dependent. Here, we aimed to investigate if an adequate TNFα pre-conditioning could increase TNFR2 expression and prime EPCs towards more immunoregulatroy functions.
Methods
EPCs were pre-treated with several doses of TNFα to find the proper dose to up-regulate TNFR2 while keeping TNFR1 stable. Then, co-cultures of human EPCs and T cells were performed to assess if EPC immunoregulatory effect is increased.
Results
Treating EPCs with 1 ng/ml TNFα significantly up-regulated TNFR2 expression without unrestrained increase of TNFR1 and other endothelial injury markers. Moreover, TNFα priming through its interaction with TNFR2 remarkably enhanced EPC immunosuppressive and anti-inflammatory effects. Conversely, TNFα-TNFR1 interaction polarized EPCs towards pro-inflammatory and immunogenic functions.
Conclusions
We report for the first time the crucial role of inflammation, notably, the implication of TNFα-TNFR2 axis to boost EPC immunoregulatory functions. Priming EPCs with proper dose of TNFα prior to administration could provide a more protective immunosuppressive microenvironment and longer lasting cells which eventually lead to their better contribution to hematopoietic and vascular regeneration.
Determinants of low breastfeeding self-efficacy amongst mothers of children aged less than six months old: Results from the BADUTA Study in East Java, Indonesia
Authors: Titaley Christiana R , Dibley Michael , Ariawan Iwan , Mu'asyaroh Anifatun , Alam Ashraful , Damayanti Rita , Tran Do Thanh , Ferguson Elaine , Kyaw Htet , Li Mu , Sutrisna Aang , Fahmida Umi
Published: September 2020

Background Despite the increasing rate of exclusive breastfeeding practice in Indonesia, supportive interventions are still required. Breastfeeding self-efficacy of mothers is a key factor positively associated with optimum breastfeeding practices. Our analysis aims to assess the determinants of low breastfeeding self-efficacy amongst a sample of women with children aged under six months in Malang and Sidoarjo Districts, East Java, Indonesia. Methods We used information from 1210 mothers of children aged <6 months recruited in the BADUTA study conducted in 2015-2016 in Malang and Sidoarjo Districts. The outcome variable in this analysis was mothers' self-efficacy for breastfeeding using the 14 statements in the Breastfeeding Self Efficacy-Short Form. In total, 17 potential predictors of breastfeeding self-efficacy were evaluated, categorised into six sub-groups: (1) context/demographic variables; (2) household characteristics; (3) maternal characteristics; (4) child characteristics; (5) breastfeeding characteristics; and (6) antenatal and delivery care characteristics. Logistic regression analyses were employed to examine factors associated with mothers' self-efficacy with breastfeeding. Results More than half of the women had a low level of self-efficacy. Factors associated with low breastfeeding self-efficacy were low levels of education, i.e. completed primary school or lower (aOR=1.95, 95%CI: 1.20-3.15), completed junior high school aOR=2.30; 95%CI: 1.44-3.69), and completed senior high school (aOR=2.01, 95%CI: 1.34-3.00); working outside the house (aOR=1.72, 95% CI: 1.26-2.35); never received any advice on breastfeeding (aOR=1.37, 95%CI: 1.04-1.81) and low knowledge of breastfeeding (aOR=1.38, 95%CI: 1.04-1.85). Problems encountered with breastfeeding was also emerged as a significant predictor for low breastfeeding self-efficacy, either for mothers receiving solutions (aOR=2.16, 95%CI: 1.58-2.95) or those not receiving any solutions (aOR=2.65, 95% CI: 1.91-3.67). Furthermore, mothers who had cesarean section deliveries were more likely to have low breastfeeding self-efficacy (aOR=1.33, 95%CI: 1.06-1.68); while mothers exposed to three or more breastfeeding interventions were more likely to have a high level of breastfeeding self-efficacy (aOR=1.84, 95%CI: 1.03-3.27). Conclusions Multipronged breastfeeding education programs and support are required to improve women's self-efficacy with breastfeeding. Improved access to breastfeeding counsellors, active support for mothers following cesarean delivery, and increased supporting facilities at workplaces are essential to improve self-efficacy with breastfeeding.
Assessing vulnerability and adopting alternative climate resilient strategies for livelihood security and sustainable management of aquatic biodiversity of Vembanad lake in India
Authors: Paul Thankam Theresa , Panikker Preetha , Sarkar U. K. , Manoharan S. , Kuberan G. , Sreenath K. R. , Zachariah P. U. , Das B. K.
Published: September 2020

The present study was carried out at the Thycattussery area in Vembanad lake and assessed the ichthyo-diversity, variability in climatic variables, the exploited status of predominant small-scale sector fisheries (SSFs) and impact of climatic variables upon an existing SSF. Fish, as well as clam specimens collected from the study area, were identified. Diversity indices and dominance curves helped to identify monsoon (June–September) as the diverse season in the wetland. SIMPER (similarity percentage) analysis indicated that Villorita cyprinoides (clam) was the predominant species in the wetland with a mean relative abundance of 16.1%. Canonical correspondence analysis (CCA) of variables with clam production identified calcium hardness and rainfall with axis loadings of –0.56 and 0.50 respectively as the variables predominantly contributing to clam production. Stepwise regression indicated that temperature and rainfall were the determinants of clam production. A decrease in rainfall and an increase in temperature at an annual rate of 0.02 and 0.8%, respectively, decreased the clam production by 5.37%/year in the study area. Further, the generalized linear model (GLM) indicated stagnancy in clam production until 2035 below 400,000 kg per year. The study introduced diversification of livelihood systems using clam culture in climate resilient pen structures (CRPS) as an adaptation strategy.
Spatiotemporal variation of actual evapotranspiration and its response to changes of major meteorological factors over China using multi-source data
Authors: Yang Jiahui , Wang Wen , Hua Tiantian , Peng Min
Published: September 2020

Evapotranspiration (ET) is an important component of the water and energy cycle. To obtain more accurate actual ET estimation, three commonly used actual ET products (i.e., GLEAM, GLDAS, and SSEBop) are merged by the simple Taylor skill score fusion method. Validation results show that the merged actual ET data exhibits better correlation with eddy-covariance ET observation than single-source ET data. Based on the merged ET, the spatiotemporal variations of ET over China and their links to changes of three meteorological factors, i.e., precipitation, air temperature (Ta), and shortwave radiation (Rs), are analyzed. During 2003–2016, there is a general upward trend in ET with an increase rate of 1.6 mm/year over China. ET increases very significantly in northeastern China, the southern coastal region, and the northwestern corner of China, whereas it decreases significantly in Huang-Huai-Hai Plain. There is a clear spatial pattern of the relationship between ET and its driving factors, i.e., the variation of ET in the humid southeast is dominated by Ta and Rs; in the semi-humid and semi-arid zone, the variation of ET is controlled mainly by precipitation, followed by Ta; and in arid northwestern China, the variation of ET is controlled mainly by precipitation.
Decoding the Inter-Relationship between Sleep Disorders and Alzheimer’s Disease Pathogenesis
Authors: Mueed Zeba , Rai Pankaj Kumar , Kamal Mohammad Amjad , Poddar Nitesh Kumar
Published: September 2020

Alzheimer’s Disease (AD), characterized by abnormally phosphorylated tau, Paired Helical
Filaments (PHFs), Neurofibrillary Tangles (NFTs), deregulated mammalian Target Of Rapamycin
(mTOR), and Aβ deposits, is a multifactorial disease with sleep disorders being one of the causative
agents. Therefore, we have reviewed the literature and have tried to decode the existence of positive
feedback, reciprocal and a bidirectional relationship allying between sleep disturbances and AD. Much
light has been thrown on the role of tau pathology and amyloid pathology in sleep pathology and its
association with AD pathology. We have also discussed the role of melatonin in regulating sleep disorders
and AD. The neuroprotective effect of melatonin via inhibiting tau hyperphosphorylation and
Aβ deposition has also been discussed. Moreover, astrocytes involvement in aggravating AD has also
been highlighted in this review. Several therapeutic approaches aimed at improving both sleep disorders
and AD have been duly discussed such as administration of antidepressants and antihistamines,
immunotherapy, metal chelators, melatonin supplementation, light therapy and physical activity. Despite
consistent efforts, the complete etiology concerning sleep disorder and AD is still unclear. Therefore,
further research is needed to unravel the mechanism involved and also to develop strategies that
may help in obstructing AD in its preclinical stage.
Venoms and Poisonings during the Centuries: A Narrative Review
Authors: Charitos Ioannis Alexandros , Gagliano-Candela Roberto , Santacroce Luigi , Bottalico Lucrezia
Published: September 2020

:

The first traces of man’s of poison use date back to ten thousand years ago since the last period of the Paleolithic era. Man used poison for hunting and defense. Indeed, in the second half of the 19th century, arrows made from the bones of animals characterized by particular grooves were found in some caves. In ancient Greece, the term pharmakon (φάρμακον) had a double meaning: remedy for therapy and venom. This is the period in which humans became aware of the fact that poison cannot be defined simply as a substance capable of changing the properties of things. Poison is very frequently mentioned in the history of the Roman Empire, and its use continued through the Renaissance and even during the modern era. Poison was the protagonist in multiple political in-trigues of power and is one of the most used lethal weapons over the years. Thought of as the opti-mal solution for a perfect murder, the poison has a long history. Its success is due to the invisible, untraceable, and often unpunished death it causes.
Disasters as Catalysts for Energy Transition
Authors: D’Alessandro Kelly , Dargusch Paul
Published: September 2020

The concept of disaster as a positive force for change seems intuitive, but is covered only
occasionally in the energy transition literature. We review disaster risk and recovery literature to assess
how these types of transformations may be different, and provide a change pathway within the
popular Multi-Level Perspective framework. While incumbent systems are, by definition, stable
(making change difficult), disaster can override these challenges by providing simultaneous disruption
at all structure levels. By exceeding the capacity of the regime and its established processes and
practices, disaster provides an opportunity to reformat social structures through reconstruction and
recovery processes. Importantly, significant disruption has the ability to plasticize the landscape for a
short timeframe, with potential change within a finite deviation from existing trends. During this disruptive
period, the regime and landscape become co-dependent, with any meso-level void filled by a
combination of new and reconstructed fragments, working to restore the stability of the foundation.
The new regime must then satisfy the resultant set of socially dictated conditions set by the revised
landscape to maintain the new structure. The challenge then is not to be restrained by the swift recovery
of the previous regime, and to form a new set of conditions to deliver improved outcomes that
better balance the needs of natural and anthropogenic systems.
Democratization in Africa: The development condition revisited
Authors: Branco Manuel Couret
Published: September 2020

In the middle of the twentieth century S.M. Lipset sustained that various indicators of economic development were higher in democratic countries than in authoritarian ones, suggesting that development was a condition to democracy. More recently, though, several authors have shown that there is no strong empirical evidence confirming development as a condition to democracy, suggesting in turn that the economic is not as important in democratization as it seemed in the 1950s. Despite this fact, there are some clues that indicate that economic factors do play an important role in democratization, but in a way different than that proposed by Lipset. In this article a revision of literature on some economic obstacles to democratization in Africa is carried out, its main conclusion being that underdevelopment decisively contributes to the difficulties many African countries experience in democratizing and consolidating democracy. One should not mistake underdevelopment with un-development though, the latter being the mere absence or delay in development and the former a specific supporting role given to developing countries within the global development process. The article’s general conclusion, therefore, is that democratic development is not a question of getting richer, i.e. intensifying the development model, as much as of reforming this same model.
Resumo

Nos meados do século XX, S.M. Lipset afirma que vários indicadores de desenvolvimento económico são mais altos em países democráticos do que em países autoritários, sugerindo que o desenvolvimento é uma condição para a democracia. Mais recentemente, vários autores sustentam que não existem evidências empíricas que confirmem o desenvolvimento como condição para a democracia, sugerindo, por sua vez, que a economia não é tão importante na democratização como aparentava ser durante a década de 50. Apesar disso, existem algumas evidências que indicam que os fatores económicos desempenham um papel importante na democratização, mas de forma diferente da proposta por Lipset. Neste artigo é feita uma revisão da literatura sobre alguns obstáculos económicos à democratização na África, e a sua principal conclusão é que o subdesenvolvimento contribui decisivamente para as dificuldades que muitos países africanos enfrentam na democratização e consolidação da democracia. Não se deve confundir subdesenvolvimento com des-desenvolvimento, sendo este último a mera ausência ou atraso no desenvolvimento e o primeiro um papel de apoio específico dado aos países em vias desenvolvimento no processo de desenvolvimento global. A conclusão geral do artigo, portanto, é que o desenvolvimento democrático não é uma questão de enriquecimento, ou seja, de intensificar o modelo de desenvolvimento, mas de reformar esse mesmo modelo.
Danos colaterais: a Organização Mundial do Comércio e a «guerra comercial» EUA-China
Authors: Fernandes José Pedro Teixeira
Published: September 2020

Resumo

Uma ‘guerra comercial’ entre as duas maiores potencias comerciais estaduais (os EUA e a China) eclodiu nos últimos anos, provocando efeitos negativos no comércio internacional. Face a este contexto, o principal objectivo deste artigo é procurar compreender a forma como o conflito comercial EUA-China se projecta nesta. Para responder a este objectivo foi usada uma metodologia de tipo qualitativo assente numa pesquisa documental e complementarmente num recurso à literatura científica relevante para esta temática. Foram ainda usados estudos empíricos para obtenção de dados quantitativos sobre litígios comerciais internacionais. Quanto à análise, foi estruturada da seguinte forma. Um primeiro ponto aborda a formação do sistema comercial global contemporâneo. Em seguida é analisada a transformação do optimismo inicial sobre a OMC num crescente cepticismo. É ainda discutido o impacto que a adesão da China à OMC teve na perda de atracção euro-americanapela organização. Nos pontos subsequentes são analisadas as repercussões da «guerra comercial» EUA-China no Órgão de Resolução de Litígios e o uso da excepção de segurança. A análise termina com uma breve reflexão sobre a forma como os problemas e as tendências identificados se projectam no futuro da OMC e do comércio global.
PENGARUH MOTIVASI BELAJAR EKONOMI DAN LINGKUNGAN TEMAN SEBAYA TERHADAP HASIL BELAJAR MATA PELAJARAN EKONOMI SISWA KELAS X
Authors: Karimah Neni Afriul , Sunanik Sunanik
Published: September 2020

Abstrak: Tujuan dari penelitian ini adalah : (1) mengetahui pengaruh motivasi belajar ekonomi terhadap hasil belajar mata pelajaran ekonomi siswa kelas X SMAN 1 Kampak tahun pelajaran 2017/2018, (2) mengetahui pengaruh lingkungan teman sebaya  terhadap hasil belajar mata pelajaran ekonomi siswa kelas X SMAN 1 Kampak tahun pelajaran 2017/2018, (3) mengetahui pengaruh motivasi belajar ekonomi dan lingkungan teman sebaya terhadap hasil belajar mata pelajaran ekonomi siswa kelas X SMAN 1 Kampak tahun ajaran 2017/2018. Populasi penelitian ini adalah siswa kelas X SMA Negeri 1 Kampak yang berjumlah 185 siswa. Sampel diambil 40% dari populasi yaitu sebanyak 74 siswa. Teknik pengambilan sampling dilakukan dengan Proporsional random sampling. Dengan demikian penelitian ini disimpulkan “ada pengaruh signifikan antara motivasi belajar ekonomi dan lingkungan teman sebaya terhadap hasil belajar mata pelajaran ekonomi”. Hasil penelitian ini dapat digunakan untuk masukan dalam meningkatkan hasil belajar mata pelajaran ekonomi.Abstract: This research aims to (1) identify whether or not the influence of Economic learning motivation toward learning results in Economic subject in grade X students in SMAN 1 Kampak 2017/2018 exists, (2) identify whether or not the influence of peer environment toward learning results in Economic subject in grade X students in SMAN 1 Kampak 2017/2018 exists, (3) identify whether or not Economic learning motivation and peer environment toward learning results in Economic subject in grade X students in SMAN 1 Kampak 2017/2018 exist. The population of this research is all grade X students in SMAN 1 Kampak. 185 students become the population of this research. The sample of this research is 40% of the population. 74 students become the sample of this research. Proportional random sampling is used as a sampling technique for this research. Therefore, it can be concluded that there is a significant influence between Economic learning motivation and peer environment toward students’ learning results. The results of this research can then be used as a consideration to advance the students’ learning results in Economic subject.
PENERAPAN MODEL PEMBELAJARAN EXAMPLES NON EXAMPLES PADA MATERI KELOMPOK SOSIAL DALAM UPAYA PENINGKATAN PARTISIPASI DAN HASIL BELAJAR PESERTA DIDIK DI SMAN 2 BANJAR
Authors: Hadi Saeful
Published: September 2020

Abstrak: Penelitian ini bertujuan untuk mengetahui penerapan model pembelajaran Examples Non Examples ditinjau dari partisipasi dan hasil belajar peserta didik di SMAN 2 Banjar. Penelitian ini merupakan penelitian tindakan kelas dengan menggunakan 2 siklus. Pada setiap siklus terdiri dari perencanaan, pelaksanaan, observasi dan refleksi. Subjek pada penelitian ini adalah peserta didik kelas XI. IPS4 SMA Negeri 2 Banjar pada materi Kelompok Sosial pada mata pelajaran Sosiologi. Berdasarkan hasil penelitian menunjukkan peningkatan hasil yang dicapai peserta didik dalam menguasai materi kelompok sosial. Peningkatan partisipasi belajar hasil pengamatan dari pengamatan awal sampai siklus 2 mengalami peningkatan yaitu 57,69% (siklus 1) menjadi 81,73% (siklus 2), nilai rerata tes ada peningkatan dari siklus 1 yaitu dengan rata-rata nilai 70,45 ke siklus 2 yaitu dengan rerata nilai 78,29 serta jumlah peserta didik yang tuntas dan persentase ketuntasan belajar pun meningkat dari 17 orang atau 54,84 % menjadi 24 orang atau 77,42%  pada siklus 2.Abstract: This study aims to determine the application of learning models Examples Non Examples in terms of participation and learning outcomes of students at SMAN 2 Banjar. This research is a classroom action research using two cycles. In each cycle consists of planning, implementation, observation and reflection. The subjects in this study were students of class XI. IPS4 SMA 2 Banjar on Social Group material on Sociology subjects. Based on the results of the study showed an increase in the results achieved by students in mastering social group material. Increased learning participation observations from the initial observation until the second cycle experienced an increase of 57.69% (cycle 1) to 81.73% (cycle 2), the average score of the test was an increase from cycle one which is an average of 70.45 to cycle 2 is the average value of 78.29 and the number of students who complete and the percentage of mastery learning increases from 17 people or 54.84% to 24 people or 77.42% in cycle 2.
PENGARUH TINGKAT PENGETAHUAN, KUALITAS LAYANAN, DAN TINGKAT LITERASI KEUANGAN SYARIAH TERHADAP PENGAMBILAN KEPUTUSAN MASYARAKAT MUSLIM MENGGUNAKAN PRODUK PERBANKAN SYARIAH DI DAERAH ISTIMEWA YOGYAKARTA
Authors: Handida Rahmawati Deylla , Sholeh Maimun
Published: September 2020

Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh Tingkat Pengetahuan, Kualitas Layanan, dan Tingkat Literasi Keuangan Syariah baik secara parsial maupun simultan terhadap Pengambilan Keputusan Masyarakat Muslim Menggunakan Produk Perbankan Syariah di Daerah Istimewa Yogyakarta. Penelitian ini merupakan jenis penelitian kuantitatif dengan pendekatan asosiatif kausal. Populasi dalam penelitian ini adalah masyarakat muslim yang menggunakan produk perbankan syariah di DIY. Sampel penelitian berjumlah 100 masyarakat muslim dengan menggunakan metode purposive sampling. Teknik pengumpulan data yang digunakan adalah kuesioner. Teknik analisis data yang digunakan yaitu analisis regresi linear ganda. Hasil penelitian menunjukkan bahwa tingkat pengetahuan, kualitas layanan, dan tingkat literasi keuangan syariah berpengaruh positif dan signifikan terhadap keputusan masyarakat muslim menggunakan produk perbankan syariah di DIY baik secara parsial maupun simultan.Abstract: This research aims to know the impact of knowledge level, service quality, and Islamic financial literacy level partially and simultaneously toward taking decision Muslim community to use Syariah banking product in Daerah Istimewa Yogyakarta (DIY). This study was classified into quantitative research with a causal associative approach. The research population comprised Muslim community who used Syariah banking product in DIY. The sample of this study was a hundred Muslim community, was selected by using a purposive sampling technique. The data were collected by using a questionnaire. The data were analyzed using multiple linear regression analysis. The result of the study shows that the knowledge level, the service quality, and the Islamic financial literacy have significant effects towards taking decision Muslim community to use Syariah banking product in DIY partially and simultaneously.
Classification of Depression Through Resting-State Electroencephalogram as a Novel Practice in Psychiatry: Review
Authors: Čukić Milena , López Victoria , Pavón Juan
Published: September 2020

Background

Machine learning applications in health care have increased considerably in the recent past, and this review focuses on an important application in psychiatry related to the detection of depression. Since the advent of computational psychiatry, research based on functional magnetic resonance imaging has yielded remarkable results, but these tools tend to be too expensive for everyday clinical use.

Objective

This review focuses on an affordable data-driven approach based on electroencephalographic recordings. Web-based applications via public or private cloud-based platforms would be a logical next step. We aim to compare several different approaches to the detection of depression from electroencephalographic recordings using various features and machine learning models.

Methods

To detect depression, we reviewed published detection studies based on resting-state electroencephalogram with final machine learning, and to predict therapy outcomes, we reviewed a set of interventional studies using some form of stimulation in their methodology.

Results

We reviewed 14 detection studies and 12 interventional studies published between 2008 and 2019. As direct comparison was not possible due to the large diversity of theoretical approaches and methods used, we compared them based on the steps in analysis and accuracies yielded. In addition, we compared possible drawbacks in terms of sample size, feature extraction, feature selection, classification, internal and external validation, and possible unwarranted optimism and reproducibility. In addition, we suggested desirable practices to avoid misinterpretation of results and optimism.

Conclusions

This review shows the need for larger data sets and more systematic procedures to improve the use of the solution for clinical diagnostics. Therefore, regulation of the pipeline and standard requirements for methodology used should become mandatory to increase the reliability and accuracy of the complete methodology for it to be translated to modern psychiatry.
Using the primary site as a prognostic tool for nodal mantle cell lymphoma: a SEER-based study
Authors: Kamel Mohamed Gomaa , El-Qushayri Amr Ehab , Sayed Ahmed Kamal , Huy Nguyen Tien
Published: September 2020

Background:Nodal mantle cell lymphoma (NMCL) has a worse survival than extra-nodal mantle cell lymphoma.Materials & methods:A cohort study was conducted to evaluate the primary site role as a mortality predictor using data from 1983 to 2011 from the Surveillance, Epidemiology, and End Results (SEER) database.Results:Most patients had NMCL in multiple regions (71.9%). There was a significantly increased incidence of NMCL cases over years with 83.2% of them occurred between 1998 and 2011. The mean survival was 52.9 months with overall survival/cancer-specific survival rate of 29.2/42.9%, respectively. Lymph nodes of intrathoracic and multiple regions had a worse overall survival while the head, face and neck, intra-abdominal, pelvic, inguinal region and leg as well as multiple regions had worse cancer-specific survival.Conclusion:NMCL primary site can serve as a prognostic factor. We encourage adding it to MCL International Prognostic Index.
IN MEMORIAM – VESELIN ĐURETIĆ
Authors: Zutic Nikola
Published: September 2020

Prognanik iz srpske istorijske nauke

Poslije duge i teške bolesti, koju je stoički i optimistički podnosio, preminuo je veliki srpski istoričar dr Veselin Đuretić. Rođen je u Mojanovićima, u srpskoj Zeti, 17. maja 1933. a preminuo u Beogradu 18. februara 2020. godine. Bio je dugogodišnji naučni savjetnik Balkanološkog instituta SANU i jedno kraće vreme Instituta za savremenu istoriju. U ratnim godinama postao je i član Senata Republike Srpske. U vreme rata za odbranu zapadnog srpstva (1991-95), u više navrata je boravio u najzapadnijoj srpskoj zemlji – Republici Srpskoj Krajini, sokoleći narod i trezneći ga od jugokomunističkih zabluda.
O ruskoj/sovjetskoj teoriji etnosa u nauci i društvu
Authors: Miljkovic Matic Jelena
Published: September 2020

Prikaz knjige:

David G. Anderson, Dmitry V. Arzyutov and Sergei Alymov (ed.), 2019, Life Histories of Etnos Theory in Russia and Beyond, Cambridge, UK: Open Book Publishers, pp. 450 https://www.openbookpublishers.com/product/823
ZAPADNI BALKAN KAO PUER AETHERNUS: PRILOG ČITANJU JEDNOG MITA
Authors: Lazarevic Radak Sanja
Published: September 2020

Povratak na modernističke teorije, obogaćene postmodernim iskustvom i metodologijom, omogućio je Darenu Kelsiju (Darren Kelsey), sintezu kritičke analize diskursa, teorija reprezentacije i teorije o afektivnom kvalitetu mitologije. Iz ove sinteze proizašli su inovativni zaključci u vezi sa načinima na koje u sferi političkog funkcionišu mitske matrice. Na osnovama pretpostavke o međuzavisnosti jezika, reprezentacije, afekta i političkog mita, u radu se analiziraju upotrebe reprezentacija o mladosti od 19. veka do danas, na (Zapadnom) Balkanu. Cilj rada je izdvajanje elemenata diskursa koji, uključeni u sferu ideološkog, postaju konstanta u okvirima istorije sećanja, legitimizacija prošlosti i konstruisanja/imaginiranja budućnosti. Reč je o afektivnoj mitologiji puer/puella aethernus koja se s obzirom na svoju sadržajnost prilagođava, kako istorijskom tako političkom kontekstu.
POLITIKA PROŠIRENJA EVROPSKE UNIJE U POTRAZI ZA REFORMOM
Authors: Kovacevic Maja
Published: September 2020

Zasedanje Evropskog saveta u oktobru 2019. godine na kojem nije postignuta saglasnost zemalja članica o otvaranju pristupnih pregovora sa Albanijom i Severnom Makedonijom je vratilo politiku proširenja Evropske unije (EU) u žižu medijske i političke pažnje i ogolilo razmere krize politike proširenja EU na Zapadni Balkan. Na insistiranje pojedinih zemalja članica, predvođenih Francuskom, Evropska komisija je u februaru 2020. godine predložila izmene metodologije pristupanja. Cilj ovog rada je da kritički razmotri kako politiku proširenja EU na Zapadni Balkan, tako i novu metodologiju. U istraživanju je korišćen model spoljnih podsticaja Frank Šimelfeniga (Frank Schimmelfennig) i Ulrih Sedelmajera (Ulrich Sedelmeier), koji je razvijen kako bi se analizirala evropeizacija zemalja Centralne i Istočne Evrope putem uslovljavanja koje je EU vršila u procesu pristupanja. Primena ovog modela na politiku proširenja na Zapadnom Balkanu pokazuje da najveći problem aktuelne politike nije u metodologiji pristupanja, već u nekredibilnom uslovljavanju koje je EU u poslednjih dvadeset godina primenjivala u odnosu na potencijalne članice iz ovog regiona. U radu se dokazuje teza da su zemlje članice EU i do sada imale na raspolaganju mehanizme kojima su mogle da odlučnije primenjuju uslovljavanje u odnosu na zemlje Zapadnog Balkana, ali to nisu činile. Stoga uzroke problema politike proširenja treba tražiti u odsustvu strateškog pristupa prema Zapadnom Balkanu zbog krize u samoj EU i zamora od proširenja, te se može zaključiti da reforma ima za cilj da utre put budućem diferenciranom članstvu u EU.
El mambe frente al dinero entre los yucuna del Amazonas
Authors: Fontaine Laurent
Published: September 2020

Este texto muestra el papel fundamental que desempeña el mambe entre los yukuna, similar al de la moneda moderna en las sociedades mercantiles, por cuanto tiene el privilegio sobre cualquier otro “bien” tradicional dentro de los intercambios indígenas. Además, bien sea en el plano del parentesco, del chamanismo o de la maloca, la coca es la expresión más alta de la autoridad de sus instituciones. Al hacer la comparación con la moneda oficial colombiana, el artículo explica las situaciones en que las reglas específicas de sus usos respectivos entran en confrontación, y de qué manera los indígenas son llevados a transformar su organización social a partir de reconfiguraciones que permiten articularlas una a la otra.
El Análisis cultural del derecho. Una reconstrucción de los estudios jurídicos, de Paul W. Kahn
Authors: Vera L. Juan Pablo
Published: September 2020

Reseña escrita por Juan Pablo Vera
Pendampingan Teknik Penambahan Suplemen Pada Ransum Indukan Ayam Bukan Ras Di Wilayah Plantungan Kabupaten Kendal
Authors: Krismiyanto Lilik , Mulyono Mulyono , Suthama Nyoman
Published: September 2020

Peningkatan produksi ayam bukan ras dapat dilakukan dengan perbaikan ransum yang selama ini masih diberikan pakan apa adanya. Penyediaan bahan pakan sesuai dengan kebutuhan nutrien dapat meningkatkan produktivitas. Selain itu juga harus didukung dengan manajemen pakan, pemeliharaan, dan kesehatan. Pembinaan terhadap peternak perlu didampingi terus, terutama pada majanemen pakan.  Ransum indukan ayam bukan ras biasanya menggunakan bahan pakan apa adanya, sehingga perlu adanya penambahan suplemen untuk meningkatkan produksi telur. Tujuan dalam pendampingan peternak adalah untuk memberikan informasi penambahan suplemen dalam ransum indukan ayam bukan ras. Manfaatnya adalah peternak mengetahui pentingnya suplemen dan mempraktekan cara formulasi ransum dengan penambahan suplemen. Pendampingan peternak indukan ayam bukan ras dilaksanakan di Kelompok Tani Ternak Kembangwono, Desa Plantungan, Kecamatan Sukorejo, Kabupaten Kendal, Jawa Tengah. Para peternak dibekali infomasi mengenai cara formulasi ransum, memilih bahan pakan yang murah dan tidak mengandung toksik, penambahan suplemen seperti premix, mineral mix, probiotik dan prebiotik. Pendampingan secara berkelanjutan dapat meningkatkan pengetahuan dan kemampuan peternak, sehingga output yang dihasilkan dapat memberikan calon-calon ayam yang berkualitas.
Patients With Type 2 Diabetes Have an Increased Demand for Pacemaker Treatment: A Comparison With Age- and Sex-Matched Control Subjects From the General Population
Authors: Rautio Elina , Gadler Fredrik , Gudbjörnsdottir Soffia , Franzén Stefan , Rydén Lars , Svensson Ann-Marie , Mellbin Linda G.
Published: September 2020

OBJECTIVE

Patients with type 2 diabetes have an increased risk for cardiovascular disease, including arrhythmias. The prevalence of bradyarrhythmia and the subsequent need for treatment with pacemakers (PMs) is less well explored in a contemporary patient population. The current study explores 1) whether patients with type 2 diabetes have an increased demand for PM implantation compared with an age- and sex-matched control population without diabetes and 2) patient characteristics associated with an increased demand for receiving a PM.

RESEARCH DESIGN AND METHODS

In this population-matched registry study, a total of 416,247 patients with type 2 diabetes from the Swedish National Diabetes Registry and 2,081,235 age- and sex-matched control subjects selected from the general population were included between 1 January 1998 and 31 December 2012 and followed until 31 December 2013. Mean follow-up time was 7 years. Cox proportional hazards regression analyses were performed to estimate the demand of PM treatment and the factors identifying patients with such demand.

RESULTS

Type 2 diabetes was associated with an increased need of PM treatment (hazard ratio 1.65 [95% CI 1.60–1.69]; P < 0.0001), which remained (1.56 [1.51–1.60]; P < 0.0001) after adjustments for age, sex, educational level, marital status, country of birth, and coronary heart disease. Risk factors for receiving a PM included increasing age, HbA1c, BMI, diabetes duration, and lipid- and blood pressure–lowering medication.

CONCLUSIONS

The need for PM treatment is higher in patients with type 2 diabetes than in matched population-based control subjects. Age, diabetes duration, and HbA1c seem to be risk factors for PM treatment.
Profibrotic circulating proteins and risk of early progressive renal decline in Type 2 Diabetes patients with and without albuminuria
Authors: Ihara Katsuhito , Skupien Jan , Kobayashi Hiroki , Dom Zaipul I. Md , Wilson Jonathan M. , O’Neil Kristina , Badger Hannah S. , Bowsman Lenden M. , Satake Eiichiro , Breyer Matthew D. , Duffin Kevin L. , Krolewski Andrzej S.
Published: September 2020

OBJECTIVE: The role of
fibrosis in early progressive renal decline in type 2 diabetes is unknown. Circulating
WFDC2 (WAP four-disulfide core domain protein 2) and MMP-7 (Matrilysin) are
postulated to be biomarkers of renal fibrosis. This study examined an
association of circulating levels of these proteins with early progressive
renal decline.

RESEARCH DESIGN AND METHODS: Individuals with
type 2 diabetes enrolled in the Joslin Kidney Study with eGFR ≥60 ml/min/1.73m2
were followed for 6-12 years to ascertain fast early progressive renal decline
defined as eGFR loss ≥5 ml/min/1.73m2/year.

RESULTS: A total of 1,181 individuals were
studied: 681 without and 500 with albuminuria. Median eGFR and ACR at baseline
were 97 ml/min/1.73m2 and 24 mg/g, respectively. During follow-up,
152 individuals experienced fast early progressive renal decline: 6.9% in those
with normoalbuminuria and 21% with albuminuria. In both subgroups risk of renal
decline increased with increasing baseline levels of WFDC2 (p <0.0001) and MMP-7
(p <0.0001). After adjustment for relevant clinical characteristics and known
biomarkers, an increase by one quartile in the Fibrosis Index (combination of
levels of WFDC2 and MMP-7) was associated with higher risk of renal decline (OR
1.63; 95% CI 1.30-2.04). The association was similar and statistically
significant among patients with and without albuminuria.

CONCLUSIONS: Elevation of
circulating profibrotic proteins is associated with the development of early
progressive renal decline in type 2 diabetes. This association is independent
from albuminuria status and points to the importance of the fibrotic process in
development of early renal decline.
The Role of Fetal Kidney Length and Fetal Transverse Diameter of Heart in Prediction of Gestational Age
Authors: Subrat Panda , Sankar Rudrapal Gouri , Ananya Das , Surajit Ray Baruah , Nalini Sharma
Published: September 2020

Objective: Currently there is no single ultrasonological parameter for accurate estimation of gestational age in third trimester. The present study is undertaken to validate the fetal kidney length and fetal transverse diameter of heart measurement as a measurement of fetal growth with less variability. Materials & Methods: It is a cohort study conducted in Department of Obstetrics and Gynaecology, NEIGRIHMS from 2015 to 2016. 224 women with singleton pregnancies and sure of LMP were enrolled. Each woman underwent minimum three ultrasonographic measurements- at first trimester for gestational age by CRL, at second trimester with fetal conventional biometry, at third trimester with Fetal kidney length, transverse diameter of heart and fetal conventional biometric parameters and analysed with SPSS Version22. Results: The gestational age with CRL was within three days of the menstrual age. In second trimester, conventional parameter (BPD,HC,AC,FL) were better parameters. Conventional parameter did not correspond to gestational age calculated from LMP. (BPD, R2= 0.4819, HC R2- 0.507, AC R2- 0.5175, FL R2-0.5243, Combined Conventional parameter R2- 0.5888). Fetal kidney length (R2-0.8356) and transverse diameter of heart (R2-0.8795) better correlated with gestational age. Conclusion: Kidney length and transverse diameter of heart are better predictors of gestational age in third trimester.
47, XYY Syndrome and its Association with Male Infertility: Case Report
Authors: Kumar Dr. Soni Ashish , N Dr. Reddy Sanjeeva
Published: September 2020

47, XYY syndrome is one of the most common sex chromosomal anomaly found in humans after Klinfelter syndrome (47, XXY). It is frequently associated with infertility in males. This syndrome has an extra Y chromosome (XYY) due to non-disjunction of the Y chromosome in paternal meiotic II. The presence of an extra Y chromosome causes hormonal disbalance in the gonads that responsible for abnormal function of human chorionic gonadotropin. In our case of infertile men with severe oligozoospermia that also confirm by conventional cytogenetic analysis of the peripheral blood lymphocytes revealed the constitutional karyotype of 47, XYY. This report is likely to be helpful for counselling and early management of such infertile males.
Comparison of the Effectiveness of Intraarticular Ozone Therapy and Platelet Rich Plasma Treatment in Patients with Knee Osteoarthritis
Authors: Yalçın Ümit
Published: September 2020

Background: Platelet rich plasma (PRP) has been applied for a long time in osteoarthritis (OA). Although there are studies about PRP that examining the effectiveness with agents such as hyaluronic acid and corticosteroid, there are few published literature comparing with ozone therapy (OT). The aim of this study is to compare the pain severity and functional status of OA patients undergoing intraarticular ozone and PRP injections. Methods: In a study which is made as prospective, randomized controlled study (RCS), 49 patients were included the study. In the first group (n = 24) OT, in the second group (n = 25) PRP injections were administered intraarticularly 3 times in total with one week intervals. Visual pain scale (VAS) and severity of pain were compared with Western Ontario McMaster Osteoarthritis Index (WOMAC). Results: In the PRP group, WOMAC pain, physical function and WOMAC total score were significantly lower than the OT group (p ˂ 0.05). Although VAS score decreased significantly (p ˂ 0.05) after treatment in both groups compared to pretreatment, the VAS score in the PRP group was significantly (p ˂ 0.05) lower than the OT group after treatment. Conclusion: Our study contributes to the literature in terms of limited publication about OT. However, this study shows that the results of PRP treatment are superior to OT in the treatment of knee OA.
Effect of Oral Contraceptive Pill Pretreatment on Pregnancy Rates in Patients Stimulated with GnRH Antagonists and rFSH for ICSI
Authors: Kumar Dr. Soni Ashish , N Dr. Reddy Sanjeeva
Published: September 2020

Background: After the recent introduction of GnRH antagonists in ovarian stimulation, OCP has been used for cycle scheduling purposes. Cycle programming has become more difficult with the use of GnRH antagonists, as stimulation initiation is dependent on the occurrence of menstruation. To overcome this limitation in the GnRH antagonist protocol, patients can be offered the use of pretreatment with oral contraceptive pills (OCP). Objective: To evaluate the effect of oral contraceptive pills (OCP) pretreatment on pregnancy rate in GnRH antagonist cycles. Design: Observational cohort study. Setting: Observational study performed at Sri Ramachandra institute of higher education & research Chennai. Patients: Total 115 patients included in the study from January 2019 to December 2019. All patients divided into two groups, oral contraceptives pretreated group (n-64) and oral contraceptives non treated group (n-51). Results: All oral contraceptives pretreated patients required significantly higher dose of gonadotropins (4745±1476 versus 3659±1230;P <0.0005) and significantly longer days of stimulations (12.2±1.2 versus 10.5±0.8;P <0.0005) in comparison to non-oral contraceptives treated group. There were no difference in total oocytes retrieved and fertilization rate. There were no other differences in cycle characteristics between groups. Implantation and pregnancy rates were not affected by OCP pretreatment. Conclusions: OCP pretreatment use for synchronization of follicles and cycle scheduling in GnRH-antagonist protocol, though it may be associated with longer stimulation and higher gonadotropin consumption but similar pregnancy rates.
Desafios e encaminhamentos da educação infantil em Sorocaba/SP
Authors: Silva Petula Ramanauskas Santorum e , Lima Paulo Gomes
Published: September 2020

O presente estudo é um recorte da dissertação “A judicialização na Educação Infantil entre ênfases, encaminhamentos e solicitações no município de Sorocaba/SP”. Mediante abordagem qualitativa, empregou-se a análise de conteúdo para tratamento dos dados. Para coleta dos dados os instrumentos utilizados foram: a) Roteiro de caracterização dos participantes, objetivando destacar as suas características e imersões quanto ao âmbito da educação infantil de 0 a 3 anos de idade nas creches municipais de tempo integral de Sorocaba/SP e b) Roteiro de entrevista com diretores de creches de Sorocaba/SP sobre a judicialização na educação infantil. Foram entrevistados 10 diretores de creche de tempo integral, considerando o seu aceite à participação na pesquisa, a partir do universo dos 20 convidados. O presente artigo objetiva identificou os desafios frente ao processo de judicialização nas creches sorocabanas e os caminhos apontados pelos respondentes necessários para resolução das questões.
Otredad, alteridad y corporeidad
Authors: Pincheira Muñoz Luis Enrique , Monsalve Labrador Clargina , Navarrete Ávila Marco Antonio
Published: September 2020

Este artículo se propone desarrollar una reflexión en torno a la Alteridad y Otredad, enmarcada en la teoría de Levinas y aportaciones de Frances Torralba a través de algunas reflexiones en torno a los conceptos de acogida y hospitalidad.  Partiendo de las implicaciones de la alteridad desde estas miradas, se analiza la posibilidad de su realización de cara al colonialismo hegemónico impuesto desde la epistemología occidental, lo que desde una lectura de Boaventura de Sousa puede denominarse como Epistemología Hegemónica del Norte Globalizado, y desde la que se plantean zonas del ser-otro humano y zonas del no ser- otro no humano, lugares que problematizan esta relación de alteridad entre el yo-otro de Levinas, puesto que esta nueva dialéctica negativa en donde el otro no se reconoce y se invisibiliza genera dinámicas de marginación y exclusión en donde la manifestación de la singularidad y la construcción de la identidad se dificulta.
Torsión del cordón espermático en un semental porcino
Authors: Reyes-Bossa Bernardo José , Henriquez-Crespo Ricardo José , Cardona-Álvarez José Alberto
Published: September 2020

Se reporta un caso de un semental porcino de la raza landrace, de 6 años y un peso de 250 Kg, el cual fue atendido por el servicio clínico ambulatorio del área de Clínica Médico-Quirúrgica de Grandes Animales de la Facultad de Medicina Veterinaria y Zootecnia de la Universidad de Córdoba. La anamnesis indica que el reproductor presentó un enrojecimiento de la región escrotal izquierda, así como una marcada asimetría entre ambos testículos con predominio del izquierdo, dolor e incomodidad en días anteriores, por lo que se le realizaron punciones con retirada de líquidos, pero con reincidencia posterior. Teniendo en cuenta la notable gravedad del evento y la disminución de la función reproductiva, así como el deterioro en la salud y el bienestar del animal, se decidió realizar una orquiectomía bilateral con resección escrotal. Durante el procedimiento quirúrgico bajo anestesia general, se evidenció al incidir la túnica albugínea y exponer por completo el testículo izquierdo, fue evidente una torsión en 720° del cordón espermático, así como aumento de tamaño y color negruzco, siendo indicativo de isquemia y necrosis. Se concluye la importancia de conocer que en casos de aumento de tamaño de testículos se debe considerar la torsión como una opción diagnóstica, así como la coloración negruzca del órgano como indicativo de una isquemia completa, lo que confirma una torsión testicular de más de 6 Hs, tiempo mínimo que reporta la literatura para causar daños irreversibles en el testículo.