bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Methods and References from Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State
Authors: Chien Chian-Shiu , Wang Mong-Lien , Chu Pen-Yuan , Chang Yuh-Lih , Liu Wei-Hsiu , Yu Cheng-Chia , Lan Yuan-Tzu , Huang Pin-I. , Lee Yi-Yen , Chen Yi-Wei , Lo Wen-Liang , Chiou Shih-Hwa
Published: April 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Figure S6 from KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine
Authors: Stewart Michelle L. , Tamayo Pablo , Wilson Andrew J. , Wang Stephanie , Chang Yun Min , Kim Jong W. , Khabele Dineo , Shamji Alykhan F. , Schreiber Stuart L.
Published: April 2023

A, tumor mass of the excised tumor at four weeks of treatment and change in tumor volume as measured by caliper for each tumor normalized to day zero of low dose decitabine (20 mg/kg, SC, 3x per week) or vehicle administered for four weeks in a subcutaneous xenograft model using a KRAS-mutant cell line (OVCAR8) (*, p = 0.03; Mann-Whitney). B, tumor mass of the excised tumor at four weeks of treatment and change in tumor volume for each tumor normalized to day zero of low-dose decitabine (20 mg/kg SC, 3x per week), navitoclax (100 mg/kg IP, 5x per week), or vehicle treatment administered alone or in combination for four weeks in a subcutaneous xenograft model using a KRAS-mutant cell line (OVCAR8) (**, p < 0.001; t-test). Week four treatment omitted one injection of decitabine and two injections of navitoclax.
Supplemental Figure S5 from KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine
Authors: Stewart Michelle L. , Tamayo Pablo , Wilson Andrew J. , Wang Stephanie , Chang Yun Min , Kim Jong W. , Khabele Dineo , Shamji Alykhan F. , Schreiber Stuart L.
Published: April 2023

A, quantification of western blot analysis for phosphorylation of MEK and ERK after treatment with decitabine for six days in a KRAS-mutant (MCAS) and KRAS-wild type (RMGI) ovarian cancer cell line as depicted in the main text. B, phosphorylation of MEK and ERK was probed by western blot after treatment with decitabine for six days in a KRAS-mutant ovarian cancer cell line (OVCAR8). Quantification was performed using Image J. C, KRAS-mutant ovarian cancer cell line, OVCAR8, was co-treated with decitabine and navitoclax for six days (nine replicates, mean). Data were normalized to the ATP levels (CTG) measured for the corresponding DMSO-treated controls (6 days) to illustrate the overall decrease in cell viability for the combination treatment. Data is a representative example of two independent experiments. D, combined bisulfite restriction analysis of the transcriptional start site of BNIP3 in MCAS cell line treated with decitabine (0.5 ÃŽÂ¼M) or DMSO for six days.
Supplementary Table S1 from A Molecular Portrait of High-Grade Ductal Carcinoma In Situ
Authors: Abba Martin C. , Gong Ting , Lu Yue , Lee Jaeho , Zhong Yi , Lacunza Ezequiel , Butti Matias , Takata Yoko , Gaddis Sally , Shen Jianjun , Estecio Marcos R. , Sahin Aysegul A. , Aldaz C. Marcelo
Published: April 2023

Supplementary Table S1: Description of samples employed for Exome-Seq, RNA-Seq and RRBS analysis.
Supplementary Figure S3 from A Molecular Portrait of High-Grade Ductal Carcinoma In Situ
Authors: Abba Martin C. , Gong Ting , Lu Yue , Lee Jaeho , Zhong Yi , Lacunza Ezequiel , Butti Matias , Takata Yoko , Gaddis Sally , Shen Jianjun , Estecio Marcos R. , Sahin Aysegul A. , Aldaz C. Marcelo
Published: April 2023

Supplementary Figure S3: TP53 pathway activity in invasive breast carcinomas from the TCGA-BRCA dataset.
Supplementary Figure S2 from A Molecular Portrait of High-Grade Ductal Carcinoma In Situ
Authors: Abba Martin C. , Gong Ting , Lu Yue , Lee Jaeho , Zhong Yi , Lacunza Ezequiel , Butti Matias , Takata Yoko , Gaddis Sally , Shen Jianjun , Estecio Marcos R. , Sahin Aysegul A. , Aldaz C. Marcelo
Published: April 2023

Supplementary Figure S2: Network analysis of transcripts associated with each DCIS clusters.
Supplemental Figure S8 from CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling
Authors: Moutal Aubin , Honnorat Jérôme , Massoma Patrick , Désormeaux Pauline , Bertrand Caroline , Malleval Céline , Watrin Chantal , Chounlamountri Naura , Mayeur Marie-Eve , Besançon Roger , Naudet Nicolas , Magadoux Léa , Khanna Rajesh , Ducray François , Meyronet David , Thomasset Nicole
Published: April 2023

CRMP5 expression, Notch signaling and Akt activations in GBM-stem cells of GBM_SC1 neurospheres. A) Flow cytometry analyses of double-fluorescence staining for CRMP5-Nestin, CRMP5-IQGAP1, and Nestin-Notch1 positive cells. Cells were gated on forward light scatter (FSC) and side scatter (SSC) to exclude dead cells and debris. The percentage of double labeling cells was represented on dot plot. Axes were determined accordind to the control gate. Analysis was performed with FlowJo software. B) Immunofluorescence analysis of CRMP5 expression of GBM_SC1 cells cultured in neurosphere (left panel) and differentiation medium (right panel). C) Western blot analysis of stem-cell markers expression (CD133, Musashi1, IQGAP1, Nestin, Notch1,2) and CRMP5 in GBM_SC1 cells cultured in neurospheres or differentiation medium. Notch signaling activation was evidenced by Hes and Akt activation by p-Akt expression.
Supplementary Figure S6 from G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation
Authors: Agarwal Saurabh , Lakoma Anna , Chen Zaowen , Hicks John , Metelitsa Leonid S. , Kim Eugene S. , Shohet Jason M.
Published: April 2023

Supplementary Figure S6. Gene-expression analysis in CD114+ subpopulation.
Supplementary Figure S4 from G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation
Authors: Agarwal Saurabh , Lakoma Anna , Chen Zaowen , Hicks John , Metelitsa Leonid S. , Kim Eugene S. , Shohet Jason M.
Published: April 2023

Supplementary Figure S4. Cleaved Caspase-3 staining in tumor xenografts.
Supplementary Figure S3 from G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation
Authors: Agarwal Saurabh , Lakoma Anna , Chen Zaowen , Hicks John , Metelitsa Leonid S. , Kim Eugene S. , Shohet Jason M.
Published: April 2023

Supplementary Figure S3. Estimation of G-CSF levels.
Supplemental Figure S1 from CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling
Authors: Moutal Aubin , Honnorat Jérôme , Massoma Patrick , Désormeaux Pauline , Bertrand Caroline , Malleval Céline , Watrin Chantal , Chounlamountri Naura , Mayeur Marie-Eve , Besançon Roger , Naudet Nicolas , Magadoux Léa , Khanna Rajesh , Ducray François , Meyronet David , Thomasset Nicole
Published: April 2023

Sub-cellular fractionation of (A): GL15 , (B): A172 cell lines and (C): GBM xenograft GBM_SC1. CRMP5 sub-cellular expression was analyzed by western blot, and the fraction purity was assessed using markers of each compartment: Calpain, cytosol; EGFR, membrane; histone H1, nucleus; vimentin, cytoskeleton.
Supplementary Table 4 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

List of up and down regulated genes on expression level with a p-value of 10-4 a FC of 10.
Supplementary Table 3 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Clinical data of chordoma patients. Every sample was positive for brachyury. Asterisks (*) mark the parental chordomas of the established chordoma cell lines.
Supplementary Table 1 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Detailed CGH karyograms of the chordoma cell lines as shown in the ideogram in Supplementary Figure 1 (according to ISCN: International System for Human Cytogentic Nomenclature).
Supplementary Material 2 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade
Authors: Guru Santosh Kumar , Pathania Anup Singh , Kumar Suresh , Ramesh Deshidi , Kumar Manjeet , Rana Satiander , Kumar Ajay , Malik Fayaz , Sharma P.R. , Chandan B.K. , Jaglan Sundeep , Sharma J.P. , Shah Bhahwal Ali , Tasduq Sheikh Abdullah , Lattoo Surrinder K. , Faruk Abdul , Saxena A.K. , Vishwakarma R.A. , Bhushan Shashi
Published: April 2023

Supplementary Material 2. DETAILS OF PRIMERS USED IN THE STUDY
Supplementary Figure 9 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Effect of Abemaciclib (LY2835219) on the growth of chordoma lines U-CH1, U-CH6, CAL51 (negative control), and MCF7 (positive control). Cells were grown in 96-well-plates were incubated for 3 days at 37{degree sign}C with increasing concentrations of Abemaciclib (3, 6, 10, 30, 60, 100, 300, 600, 1000 nM) in the medium or left untreated for control. The amount of viable cells was determined by using the MTS cell viability test (GraphPad Prism software, Version 6).
Supplementary Material 1 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade
Authors: Guru Santosh Kumar , Pathania Anup Singh , Kumar Suresh , Ramesh Deshidi , Kumar Manjeet , Rana Satiander , Kumar Ajay , Malik Fayaz , Sharma P.R. , Chandan B.K. , Jaglan Sundeep , Sharma J.P. , Shah Bhahwal Ali , Tasduq Sheikh Abdullah , Lattoo Surrinder K. , Faruk Abdul , Saxena A.K. , Vishwakarma R.A. , Bhushan Shashi
Published: April 2023

Supplementary Material 1. DETAILS OF ANTIBODIES USED IN THE STUDY
Supplementary Figure 2 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade
Authors: Guru Santosh Kumar , Pathania Anup Singh , Kumar Suresh , Ramesh Deshidi , Kumar Manjeet , Rana Satiander , Kumar Ajay , Malik Fayaz , Sharma P.R. , Chandan B.K. , Jaglan Sundeep , Sharma J.P. , Shah Bhahwal Ali , Tasduq Sheikh Abdullah , Lattoo Surrinder K. , Faruk Abdul , Saxena A.K. , Vishwakarma R.A. , Bhushan Shashi
Published: April 2023

Supplementary Figure 2. Schematic presentation of mechanism of action of SAD.
Supplementary Figure 1 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade
Authors: Guru Santosh Kumar , Pathania Anup Singh , Kumar Suresh , Ramesh Deshidi , Kumar Manjeet , Rana Satiander , Kumar Ajay , Malik Fayaz , Sharma P.R. , Chandan B.K. , Jaglan Sundeep , Sharma J.P. , Shah Bhahwal Ali , Tasduq Sheikh Abdullah , Lattoo Surrinder K. , Faruk Abdul , Saxena A.K. , Vishwakarma R.A. , Bhushan Shashi
Published: April 2023

Supplementary Figure 1. Molecular structure and cytotoxic profile of secalonic acid D (SAD). Colony morphology, Neighbor-joining rooted tree and sequencing of fungal endophyte (EF-VR2).
Supplementary Figure 5 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Unsupervised cluster analysis of mRNA expression data of all chordoma cell lines. The T-gene (i.e., brachyury) is overexpressed (red). Cluster Analysis of chordoma cell lines with chondrocyte, liposarcoma and sarcoma expression data from GEO and own data from a cell line with cartilaginous differentiation and from tissue of a vertebral disc.
Supplementary Materials and Methods, Figure Legends and Table S1 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Authors: Priolo Carmen , Pyne Saumyadipta , Rose Joshua , Regan Erzsébet Ravasz , Zadra Giorgia , Photopoulos Cornelia , Cacciatore Stefano , Schultz Denise , Scaglia Natalia , McDunn Jonathan , De Marzo Angelo M. , Loda Massimo
Published: April 2023

Table S1. List of gene expression assays (Applied Biosystems).
Supplementary Figure S4 from Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin
Authors: Marchiq Ibtissam , Le Floch Renaud , Roux Danièle , Simon Marie-Pierre , Pouyssegur Jacques
Published: April 2023

Figure S4: Glutamine-dependent and -independent rates of oxygen consumption are increased by BSG/MCTs disruption.
supplemental limitations of the study from NUP160–SLC43A3 Is a Novel Recurrent Fusion Oncogene in Angiosarcoma
Authors: Shimozono Naoki , Jinnin Masatoshi , Masuzawa Mamiko , Masuzawa Mikio , Wang Zhongzhi , Hirano Ayaka , Tomizawa Yukiko , Etoh-Kira Tomomi , Kajihara Ikko , Harada Miho , Fukushima Satoshi , Ihn Hironobu
Published: April 2023

supplemental limitations of the study
Supplementary Materials and Methods from NUP160–SLC43A3 Is a Novel Recurrent Fusion Oncogene in Angiosarcoma
Authors: Shimozono Naoki , Jinnin Masatoshi , Masuzawa Mamiko , Masuzawa Mikio , Wang Zhongzhi , Hirano Ayaka , Tomizawa Yukiko , Etoh-Kira Tomomi , Kajihara Ikko , Harada Miho , Fukushima Satoshi , Ihn Hironobu
Published: April 2023

Supplementary materials and methods
Supplementary Figure S2 from Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin
Authors: Marchiq Ibtissam , Le Floch Renaud , Roux Danièle , Simon Marie-Pierre , Pouyssegur Jacques
Published: April 2023

Figure S2: Disruption of BSG, by zinc finger nucleases, reduces lactic acid transport, inhibits glycolysis and sensitizes U87 cells to the MCT1 inhibitor and phenformin.
Supplementary Figure S2 from IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden
Authors: van der Zee Marten , Sacchetti Andrea , Cansoy Medine , Joosten Rosalie , Teeuwssen Miriam , Heijmans-Antonissen Claudia , Ewing-Graham Patricia C. , Burger Curt W. , Blok Leen J. , Fodde Riccardo
Published: April 2023

Supplementary Figure S2. CD133 FACS analysis.
Supplementary Figure Legends from IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden
Authors: van der Zee Marten , Sacchetti Andrea , Cansoy Medine , Joosten Rosalie , Teeuwssen Miriam , Heijmans-Antonissen Claudia , Ewing-Graham Patricia C. , Burger Curt W. , Blok Leen J. , Fodde Riccardo
Published: April 2023

Legends to Supplementary Figures
Supplemental Figure S5 from Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas
Authors: He Feng , Melamed Jonathan , Tang Moon-shong , Huang Chuanshu , Wu Xue-Ru
Published: April 2023

Supplemental Figure S5. Divergent expression of basal and luminal urothelial markers in muscle-invasive urothelial carcinoma of the bladder.
Supplementary Methods, Figures 1 - 4 from STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious
Authors: Maycotte Paola , Gearheart Christy M. , Barnard Rebecca , Aryal Suraj , Mulcahy Levy Jean M. , Fosmire Susan P. , Hansen Ryan J. , Morgan Michael J. , Porter Christopher C. , Gustafson Daniel L. , Thorburn Andrew
Published: April 2023

PDF file - 1806K, Supplementary Figure S1. Hierarchical clustering of breast cancer cell lines transduced with an autophagy-focused shRNA library produced two main clusters. Supplementary Figure S2. ATG5, ATG7 and BECN1 shRNAs decreased protein levels in all cell lines tested. Supplementary Figure S3. Autophagy inhibition induces cell death in some cell lines but not others. MCF7, MDAMB231 and MDAMB468 cells were transduced with a lentivirus expressing shRNAs against ATG7 or BECN1, plated and evaluated for cell death with propidium iodide (red) staining after 48 h. Supplementary Figure S4. Triple negative cell lines have constitutively activated JAK/STAT pathway and autophagy regulates their STAT3 phosphorylation status.
Supplementary Figure S2 from Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
Authors: Sadok Amine , McCarthy Afshan , Caldwell John , Collins Ian , Garrett Michelle D. , Yeo Maggie , Hooper Steven , Sahai Erik , Kuemper Sandra , Mardakheh Faraz K. , Marshall Christopher J.
Published: April 2023

Supplementary Figure S2. Immunoblotted of tumours lysates from CCT54 - or AT48-treated animals.
Movie S3 AT48 1microM from Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
Authors: Sadok Amine , McCarthy Afshan , Caldwell John , Collins Ian , Garrett Michelle D. , Yeo Maggie , Hooper Steven , Sahai Erik , Kuemper Sandra , Mardakheh Faraz K. , Marshall Christopher J.
Published: April 2023

Movie S3 AT48 1microM. 690 melanoma cells seeded on thick Col-I gel and treated with 1micM AT48 for 24h.
Supplementary Figure S2 from ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway
Authors: Li Xiao-Qing , Du Xin , Li Dong-Mei , Kong Peng-Zhou , Sun Yan , Liu Pei-Fang , Wang Qing-Shan , Feng Yu-Mei
Published: April 2023

Figure S2. ITGBL1 promotes the formation of osteomimetic breast cancers and increases the expression of bone metastasis-related genes.
supplementary Table 7 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

Correlation between the clinicopathologic features and expression of PAFR in colon cancer
supplementary Table 6 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

Correlation between the clinicopathologic features and expression of PAFR in breast cancer
Supplementary Methods-Figures-Tables from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Authors: Sun Yuting , Bell Jessica L. , Carter Daniel , Gherardi Samuele , Poulos Rebecca C. , Milazzo Giorgio , Wong Jason W.H. , Al-Awar Rima , Tee Andrew E. , Liu Pei Y. , Liu Bing , Atmadibrata Bernard , Wong Matthew , Trahair Toby , Zhao Quan , Shohet Jason M. , Haupt Ygal , Schulte Johannes H. , Brown Peter J. , Arrowsmith Cheryl H. , Vedadi Masoud , MacKenzie Karen L. , Hüttelmaier Stefan , Perini Giovanni , Marshall Glenn M. , Braithwaite Antony , Liu Tao
Published: April 2023

Supplementary Methods-Figures-Tables
Supplementary Dataset 3 from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Authors: Sun Yuting , Bell Jessica L. , Carter Daniel , Gherardi Samuele , Poulos Rebecca C. , Milazzo Giorgio , Wong Jason W.H. , Al-Awar Rima , Tee Andrew E. , Liu Pei Y. , Liu Bing , Atmadibrata Bernard , Wong Matthew , Trahair Toby , Zhao Quan , Shohet Jason M. , Haupt Ygal , Schulte Johannes H. , Brown Peter J. , Arrowsmith Cheryl H. , Vedadi Masoud , MacKenzie Karen L. , Hüttelmaier Stefan , Perini Giovanni , Marshall Glenn M. , Braithwaite Antony , Liu Tao
Published: April 2023

List of N-Myc non-binding gene promoters at which H3K4me3 was reduced by WDR5 siRNA.
Fig. S9 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

Evaluating the effects of Stat3 shRNA, or it in the presence of 100 nM PAF on the invasion of A549 and H460 cells using transwell invasion assay.
Fig. S2 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

PAFR expression was positively correlated with metastasis of human cancers.
Fig. S15 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

Schematic diagram of the mechanism underlying PAFR-activated Stat3 in the EMT and metastasis of NSCLC.
Supplementary Methods, Tables 1 - 6, Figures 1 - 13 from Loss of RACK1 Promotes Metastasis of Gastric Cancer by Inducing a miR-302c/IL8 Signaling Loop
Authors: Chen Ling , Min Lingqiang , Wang Xuefei , Zhao Junjie , Chen Hua , Qin Jing , Chen Weidong , Shen Zhenbin , Tang Zhaoqing , Gan Qiangjun , Ruan Yuanyuan , Sun Yihong , Qin Xinyu , Gu Jianxin
Published: April 2023

Supplementary Materials and Methods Supplementary Table 1. Correlation between RACK1 expression in gastric carcinoma and clinicopathologic factors Supplementary Table 2. Univariate and multivariate analysis of predictive factors for overall survival in gastric cancer Supplementary Table 3. Antibodies used in this study Supplementary Table 4. Calculation of the IHC/ISH composite expression score Supplementary Table 5. Human gastric cancer cell lines used in present study Supplementary Table 6. Real-time PCR primers Supplementary Figure 1. RACK1 was silenced in human gastric cancer cell lines Supplementary Figure 2. Fold change of secretion of soluble factors by human gastric cancer cells upon RACK1 silencing Supplementary Figure 3. Expression pattern of IL-8 receptors CXCR1/2 in different gastric cancer cell lines Supplementary Figure 4. RACK1 modulates the invasion of gastric cancer in IL-8 autocrine-dependent manner Supplementary Figure 5. The effect of Wnt/β-catenin inhibitor XAV-939 on RACK1 depletion-induced IL-8 expression in gastric cancer cells Supplementary Figure 6. The effect of RACK1 depletion on the expression of miR-302 cluster Supplementary Figure 7. MiR-302c modulated the expression of IL-8 in gastric cancer cells Supplementary Figure 8. Relative expression of miR-302 cluster in gastric cancer cell lines Supplementary Figure 9. The effect of RACK1 depletion on the expression of microRNAs targeting IL-8 Supplementary Figure 10. RACK1 negatively regulates IL-8 expression and tumor invasion via miR-302c in gastric cancer HGC-27 cells Supplementary Figure 11. Receiver operating characteristic (ROC) curve analysis of RACK1, IL-8 and miRNA-302c expression Supplementary Figure 12. Correlation of miRNA-302c expression with tumor invasion, lymph node metastasis, distant metastasis and TNM stage in clinical gastric cancer cases Supplementary Figure 13. Correlation of RACK1 expression with overall 5-year survival in T1 and T2-4 subgroups of gastric cancer patients by Kaplan-Meier method
Supplementary Table. S7 from Development of Lung Adenocarcinomas with Exclusive Dependence on Oncogene Fusions
Authors: Saito Motonobu , Shimada Yoko , Shiraishi Kouya , Sakamoto Hiromi , Tsuta Koji , Totsuka Hirohiko , Chiku Suenori , Ichikawa Hitoshi , Kato Mamoru , Watanabe Shun-ichi , Yoshida Teruhiko , Yokota Jun , Kohno Takashi
Published: April 2023

Supplementary Table. S7. Amplification of nine representative oncogenes in the study cohort
Figure S1 from Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer
Authors: Qu Zhaoxia , Sun Fan , Zhou Jingjiao , Li Liwen , Shapiro Steven D. , Xiao Gutian
Published: April 2023

No difference in the expression of many cytokines and chemokines in lungs of IL-6 deficient mice after induction of oncogenic K-Ras mutant expression in lungs.
Supplementary Figure 1 from HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival
Authors: Mitobe Yuichi , Yasunaga Jun-ichirou , Furuta Rie , Matsuoka Masao
Published: April 2023

The expression of HBZ protein in WT and mutant HBZ-transfected cells
Supplementary Figure S6 from Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer
Authors: Oshima Hiroko , Nakayama Mizuho , Han Tae-Su , Naoi Kuniko , Ju Xiaoli , Maeda Yusuke , Robine Sylvie , Tsuchiya Kiichiro , Sato Toshiro , Sato Hiroshi , Taketo Makoto Mark , Oshima Masanobu
Published: April 2023

Supplementary Figure S6. Gene expression of inflammatory factors in normal and IBD tissue samples.
Supplementary Figure S1 from miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
Authors: Zhang Jing , Jiao Jingjing , Cermelli Silvia , Muir Kyle , Jung Kwang Hwa , Zou Ruhai , Rashid Asif , Gagea Mihai , Zabludoff Sonya , Kalluri Raghu , Beretta Laura
Published: April 2023

Supplementary Figure S1. Hepatic phenotype in Pten null mice.
Supplementary Figure S4 from Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer
Authors: Oshima Hiroko , Nakayama Mizuho , Han Tae-Su , Naoi Kuniko , Ju Xiaoli , Maeda Yusuke , Robine Sylvie , Tsuchiya Kiichiro , Sato Toshiro , Sato Hiroshi , Taketo Makoto Mark , Oshima Masanobu
Published: April 2023

Supplementary Figure S4. Histological changes of X-ray-irradiated wild-type and Tgfbr2ÃŽ?IEC mouse intestines.
Supplementary Figure S3 from Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer
Authors: Oshima Hiroko , Nakayama Mizuho , Han Tae-Su , Naoi Kuniko , Ju Xiaoli , Maeda Yusuke , Robine Sylvie , Tsuchiya Kiichiro , Sato Toshiro , Sato Hiroshi , Taketo Makoto Mark , Oshima Masanobu
Published: April 2023

Supplementary Figure S3. Histology of intestines of Tgfbr2ÃŽ?IEC mice.
Supplementary Movie from Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition
Authors: Xiao Lin , Kim Dae Joong , Davis Clayton L. , McCann James V. , Dunleavey James M. , Vanderlinden Alissa K. , Xu Nuo , Pattenden Samantha G. , Frye Stephen V. , Xu Xia , Onaitis Mark , Monaghan-Benson Elizabeth , Burridge Keith , Dudley Andrew C.
Published: April 2023

Supplementary Movie. Three-dimensional projection of confocal z-stack immunofluorescent images of SMA+/ZsGreen+ cells in ZsGreenCdh5-Cre mouse mammary tumors. Orthotopic E0771 tumors from the ZsGreenCdh5-Cre mice with vessels endogenously labeled with ZsGreen (green) were immunostained with SMA (red).
Supplemental Figure S5 from Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition
Authors: Xiao Lin , Kim Dae Joong , Davis Clayton L. , McCann James V. , Dunleavey James M. , Vanderlinden Alissa K. , Xu Nuo , Pattenden Samantha G. , Frye Stephen V. , Xu Xia , Onaitis Mark , Monaghan-Benson Elizabeth , Burridge Keith , Dudley Andrew C.
Published: April 2023

Supplemental Figure S5. bFGF suppresses TGFβ2-induced SMA expression in multiple EC clones.
Table S2 from A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway
Authors: Jiang Yan , Pan Yong , Rhea Patrea R. , Tan Lin , Gagea Mihai , Cohen Lorenzo , Fischer Susan M. , Yang Peiying
Published: April 2023

Other HETEs were quantified in the mouse tumor models.
Supplemental methods from A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway
Authors: Jiang Yan , Pan Yong , Rhea Patrea R. , Tan Lin , Gagea Mihai , Cohen Lorenzo , Fischer Susan M. , Yang Peiying
Published: April 2023

Experimental methods are described in detail.
Supplemental Figure Legends from Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition
Authors: Xiao Lin , Kim Dae Joong , Davis Clayton L. , McCann James V. , Dunleavey James M. , Vanderlinden Alissa K. , Xu Nuo , Pattenden Samantha G. , Frye Stephen V. , Xu Xia , Onaitis Mark , Monaghan-Benson Elizabeth , Burridge Keith , Dudley Andrew C.
Published: April 2023

Legends for Supplemental Figures S1-S7.
Supplementary Table 2 from MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells
Authors: Koch Adam T. , Love-Homan Laurie , Espinosa-Cotton Madelyn , Stanam Aditya , Simons Andrean L.
Published: April 2023

SQ20B Network list.
Supplementary Table 1 from MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells
Authors: Koch Adam T. , Love-Homan Laurie , Espinosa-Cotton Madelyn , Stanam Aditya , Simons Andrean L.
Published: April 2023

PCR primer description table.
Supplementary Figure Legends from MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells
Authors: Koch Adam T. , Love-Homan Laurie , Espinosa-Cotton Madelyn , Stanam Aditya , Simons Andrean L.
Published: April 2023

This is the figure legends for the supplementary figures.
Supplementary Figure 4 from MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells
Authors: Koch Adam T. , Love-Homan Laurie , Espinosa-Cotton Madelyn , Stanam Aditya , Simons Andrean L.
Published: April 2023

ZVAD protects HNSCC cells from erlotinib-induced cell death.
Supplemental figure legends from Fas Ligand Deficiency Impairs Tumor Immunity by Promoting an Accumulation of Monocytic Myeloid-Derived Suppressor Cells
Authors: Peyvandi Sanam , Buart Stéphanie , Samah Boubekeur , Vétizou Marie , Zhang Yanyan , Durrieu Ludovic , Polrot Mélanie , Chouaib Salem , Benihoud Karim , Louache Fawzia , Karray Saoussen
Published: April 2023

Supplemental figure legends
Supplementary Table S4 from Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival
Authors: Schliekelman Mark J. , Taguchi Ayumu , Zhu Jun , Dai Xudong , Rodriguez Jaime , Celiktas Muge , Zhang Qing , Chin Alice , Wong Chee-Hong , Wang Hong , McFerrin Lisa , Selamat Suhaida A. , Yang Chenchen , Kroh Evan M. , Garg Kavita S. , Behrens Carmen , Gazdar Adi F. , Laird-Offringa Ite A. , Tewari Muneesh , Wistuba Ignacio I. , Thiery Jean P. , Hanash Samir M.
Published: April 2023

Supplementary Table S4. Aggressive hybrid protein signature and gene ontology.
Supplementary Table S3 from Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer
Authors: Ylipää Antti , Kivinummi Kati , Kohvakka Annika , Annala Matti , Latonen Leena , Scaravilli Mauro , Kartasalo Kimmo , Leppänen Simo-Pekka , Karakurt Serdar , Seppälä Janne , Yli-Harja Olli , Tammela Teuvo L.J. , Zhang Wei , Visakorpi Tapio , Nykter Matti
Published: April 2023

Comparisons of different tumor types.
Supplementary Methods and References from Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer
Authors: Ylipää Antti , Kivinummi Kati , Kohvakka Annika , Annala Matti , Latonen Leena , Scaravilli Mauro , Kartasalo Kimmo , Leppänen Simo-Pekka , Karakurt Serdar , Seppälä Janne , Yli-Harja Olli , Tammela Teuvo L.J. , Zhang Wei , Visakorpi Tapio , Nykter Matti
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Figure S4 from Induction of Vasculogenic Mimicry Overrides VEGF-A Silencing and Enriches Stem-like Cancer Cells in Melanoma
Authors: Schnegg Caroline I. , Yang Moon Hee , Ghosh Subrata K. , Hsu Mei-Yu
Published: April 2023

Supplemental Figure S4. VEGF-A KD modulates VM formation in WM1617 melanoma xenografts.
Supplemental Figure S2 from Induction of Vasculogenic Mimicry Overrides VEGF-A Silencing and Enriches Stem-like Cancer Cells in Melanoma
Authors: Schnegg Caroline I. , Yang Moon Hee , Ghosh Subrata K. , Hsu Mei-Yu
Published: April 2023

Supplemental Figure S2. VEGF-A KD retards tumorigenicity in WM1617 but not A2058 melanoma xenografts.
Supplemental Figure S1 from Induction of Vasculogenic Mimicry Overrides VEGF-A Silencing and Enriches Stem-like Cancer Cells in Melanoma
Authors: Schnegg Caroline I. , Yang Moon Hee , Ghosh Subrata K. , Hsu Mei-Yu
Published: April 2023

Supplemental Figure S1. VEGF-A silencing in WM1617, C8161 and A2058 melanoma cells by plasmid-based shRNA (sh2).
Supplementary Figure S2 from Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival
Authors: Langenkamp Elise , Zhang Lei , Lugano Roberta , Huang Hua , Elhassan Tamador Elsir Abu , Georganaki Maria , Bazzar Wesam , Lööf Johan , Trendelenburg George , Essand Magnus , Pontén Fredrik , Smits Anja , Dimberg Anna
Published: April 2023

CD93 does not affect HDMEC proliferation or apoptosis but alters the endothelial cytoskeleton through interaction with moesin.
Supplementary Text from Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Authors: Kothari Anisha , Hittelman Walter N. , Chambers Timothy C.
Published: April 2023

Portions of Materials and Methods and Supplementary Figure Legends
Figure S9 from Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Authors: Kothari Anisha , Hittelman Walter N. , Chambers Timothy C.
Published: April 2023

Supplementary Figure 9
Suppl. Movie 1 from LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers
Authors: Prunier Chloé , Josserand Véronique , Vollaire Julien , Beerling Evelyne , Petropoulos Christos , Destaing Olivier , Montemagno Christopher , Hurbin Amandine , Prudent Renaud , de Koning Leanne , Kapur Reuben , Cohen Pascale A. , Albiges-Rizo Corinne , Coll Jean-Luc , van Rheenen Jacco , Billaud Marc , Lafanechère Laurence
Published: April 2023

FRAP analysis of actin dynamics in invadopodia treated with vehicle or Pyr1
Supplemental Table S7 A. from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Authors: Harms Paul William , Vats Pankaj , Verhaegen Monique Elise , Robinson Dan R. , Wu Yi-Mi , Dhanasekaran Saravana Mohan , Palanisamy Nallasivam , Siddiqui Javed , Cao Xuhong , Su Fengyun , Wang Rui , Xiao Hong , Kunju Lakshmi P. , Mehra Rohit , Tomlins Scott A. , Fullen Douglas Randall , Bichakjian Christopher Keram , Johnson Timothy M. , Dlugosz Andrzej Antoni , Chinnaiyan Arul M.
Published: April 2023

Supplemental Table S7 A. Selected somatic mutation calls and Sanger validation results
Supplementary Fig. S7 from Combining miR-10b–Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer
Authors: Yoo Byunghee , Kavishwar Amol , Ross Alana , Wang Ping , Tabassum Doris P. , Polyak Kornelia , Barteneva Natalia , Petkova Victoria , Pantazopoulos Pamela , Tena Aseda , Moore Anna , Medarova Zdravka
Published: April 2023

Supplementary Fig. S7. Long-term cancer-free survival.
Supplementary Fig. S2 from Combining miR-10b–Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer
Authors: Yoo Byunghee , Kavishwar Amol , Ross Alana , Wang Ping , Tabassum Doris P. , Polyak Kornelia , Barteneva Natalia , Petkova Victoria , Pantazopoulos Pamela , Tena Aseda , Moore Anna , Medarova Zdravka
Published: April 2023

Supplementary Fig. S2. Nuclear and cytoskeletal reorganization by the treatment in metastatic breast cancer cells.
Supplemental Figure S3 from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Authors: Harms Paul William , Vats Pankaj , Verhaegen Monique Elise , Robinson Dan R. , Wu Yi-Mi , Dhanasekaran Saravana Mohan , Palanisamy Nallasivam , Siddiqui Javed , Cao Xuhong , Su Fengyun , Wang Rui , Xiao Hong , Kunju Lakshmi P. , Mehra Rohit , Tomlins Scott A. , Fullen Douglas Randall , Bichakjian Christopher Keram , Johnson Timothy M. , Dlugosz Andrzej Antoni , Chinnaiyan Arul M.
Published: April 2023

Supplemental Figure S3. Supplemental Figure S3 HRAS and PRUNE2 mutations in MCC
Supplemental Figure Legends from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Authors: Harms Paul William , Vats Pankaj , Verhaegen Monique Elise , Robinson Dan R. , Wu Yi-Mi , Dhanasekaran Saravana Mohan , Palanisamy Nallasivam , Siddiqui Javed , Cao Xuhong , Su Fengyun , Wang Rui , Xiao Hong , Kunju Lakshmi P. , Mehra Rohit , Tomlins Scott A. , Fullen Douglas Randall , Bichakjian Christopher Keram , Johnson Timothy M. , Dlugosz Andrzej Antoni , Chinnaiyan Arul M.
Published: April 2023

Supplemental Figure Legends
Supplementary Figures 1 - 6, Table 1 from Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem–like Cell Traits in Breast Cancer
Authors: Liang Yajun , Hu Jing , Li Jiatao , Liu Yingjie , Yu Jingyi , Zhuang Xueqian , Mu Lili , Kong Xiangyin , Hong Dengli , Yang Qifeng , Hu Guohong
Published: April 2023

Fig. S1. CSC abundance, expression of ABC transporters and cancer cell chemoresistance after MTDH knockdown or overexpression. Fig. S2. Expression of EMT marker proteins after MTDH knockdown or overexpression. Fig. S3. CSC abundance and in vivo tumorigencity of DU145 cells after MTDH knockdown. Fig. S4. TWIST1 expression was regulated by histone acetylation. Fig. S5. The CBP homolog p300 was not involved in MTDH regulation of TWIST1. Fig. S6. TWIST1+ cells are co-localized with MTDH+ cells at invasive tumor front (ITF). Table S1: The sequences of primers and shRNA constructs used in the study.
Supplementary Figure S6 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: April 2023

Inhibitory effect of BYL719 on the growth of orthotopic lung tumors of defined Kras or Pik3ca genotype.
Supplementary Table 1, Supplementary Methods, and Supplementary Figure Legends from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Authors: Caetano Mauricio S. , Zhang Huiyuan , Cumpian Amber M. , Gong Lei , Unver Nese , Ostrin Edwin J. , Daliri Soudabeh , Chang Seon Hee , Ochoa Cesar E. , Hanash Samir , Behrens Carmen , Wistuba Ignacio I. , Sternberg Cinthya , Kadara Humam , Ferreira Carlos Gil , Watowich Stephanie S. , Moghaddam Seyed Javad
Published: April 2023

Table 1. List of Q-RT-PCR primers. Supplementary methods and supplementary figure legends.
Supplementary Figure S1 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: April 2023

Comparison of ERK1/2 and AKT activation in KRASG12D- versus KRASG12D/PIK3CAH1047R-driven lung tumors.
Supplementary Figure 2 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Authors: Caetano Mauricio S. , Zhang Huiyuan , Cumpian Amber M. , Gong Lei , Unver Nese , Ostrin Edwin J. , Daliri Soudabeh , Chang Seon Hee , Ochoa Cesar E. , Hanash Samir , Behrens Carmen , Wistuba Ignacio I. , Sternberg Cinthya , Kadara Humam , Ferreira Carlos Gil , Watowich Stephanie S. , Moghaddam Seyed Javad
Published: April 2023

Supplementary Figure 2. (A) Heatmap representing IL-6/STAT3 pathway genes expression status. (B-C) Mass spectrometric quantification of IL-6 and STAT3 in lung cancer cell lines. (D) Siltuximab and Tocilizumab decreased STAT3 activation in NSCLC cell lines.
Supplementary Figure 1 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Authors: Caetano Mauricio S. , Zhang Huiyuan , Cumpian Amber M. , Gong Lei , Unver Nese , Ostrin Edwin J. , Daliri Soudabeh , Chang Seon Hee , Ochoa Cesar E. , Hanash Samir , Behrens Carmen , Wistuba Ignacio I. , Sternberg Cinthya , Kadara Humam , Ferreira Carlos Gil , Watowich Stephanie S. , Moghaddam Seyed Javad
Published: April 2023

Supplementary Figure 1. Gating method for FACS analysis and sorting.
Supplementary Figure Legends from Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
Authors: Emir Uzay E. , Larkin Sarah J. , de Pennington Nick , Voets Natalie , Plaha Puneet , Stacey Richard , Al-Qahtani Khalid , Mccullagh James , Schofield Christopher J. , Clare Stuart , Jezzard Peter , Cadoux-Hudson Tom , Ansorge Olaf
Published: April 2023

Legends for Supplementary Figures S1-S5.
Supplemental Figure S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Authors: Zhu Jieqing , Xiong Gaofeng , Fu Hanjiang , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: April 2023

Supplemental Figure S1. Hsp47 expression is upregulated in various cancers, but the upregulation is not sufficient to induce transformation.
Supplemetary Video S8 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: April 2023

Video S8. Ela-Myc cells on 3D-ECM generated by TGFÃŽÂ²-treated KO MEFs.
Supplemetary Video S7 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: April 2023

Video S7. Ela-Myc cells on 3D-ECM generated by KO MEFs.
Supplemetary Video S6 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: April 2023

Video S6. Ela-Myc cells on 3D-ECM generated by TGFÃŽÂ²-treated Control MEFs.
Supplemetary Video S5 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: April 2023

Video S5. Ela-Myc cells on 3D-ECM generated by Control MEFs.
Supplemental Table 1 from A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Authors: Heilmann Silja , Ratnakumar Kajan , Langdon Erin M. , Kansler Emily R. , Kim Isabella S. , Campbell Nathaniel R. , Perry Elizabeth B. , McMahon Amy J. , Kaufman Charles K. , van Rooijen Ellen , Lee William , Iacobuzio-Donahue Christine A. , Hynes Richard O. , Zon Leonard I. , Xavier Joao B. , White Richard M.
Published: April 2023

Supplemental Table 1. This is data on the number of attempted zebrafish cell lines and our success rates in terms of long term propagation and weaning off fibronectin.
Supplemental Figures 1-20 from A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Authors: Heilmann Silja , Ratnakumar Kajan , Langdon Erin M. , Kansler Emily R. , Kim Isabella S. , Campbell Nathaniel R. , Perry Elizabeth B. , McMahon Amy J. , Kaufman Charles K. , van Rooijen Ellen , Lee William , Iacobuzio-Donahue Christine A. , Hynes Richard O. , Zon Leonard I. , Xavier Joao B. , White Richard M.
Published: April 2023

Supplemental Figures 1-20. Supplemental Figure 1: Metastatic behavior of primary melanoma transplants. Supplemental Figure 2: Demonstration of cDNA overexpression in the ZMEL1 line. Supplemental Figure 3: Demonstration of CRISPR/Cas9-mediated mutation in the ZMEL1 line. Supplemental Figure 4: SURVEYOR assay to assess mutation rates in ZMEL1 cells nucleofected with CRISPR/Cas9 constructs. Supplemental Figure 5: Gene Set Enrichment Analysis (GSEA) for the ZMEL1 transcriptional signature compared to the NCI60 human cancer cell lines (dataset NCI60GSE5846). Supplemental Figure 6: Heatmap plot of the ZMEL1 transcriptional signature compared to the NCI60 human cancer cell lines (dataset NCI60GSE5846). Supplemental Figure 7: Gene Set Enrichment Analysis (GSEA) for the ZMEL1 compared to transgenic mitf-BRAF;p53 tumors. Supplemental Figure 8: Heatmap plot of the ZMEL1 transcriptional signature compared to transgenic mitf-BRAF;p53 tumors. Supplemental Figure 9: Ingenuity Pathway Analysis of the ZMEL1 expression signature showing canonical pathways. Supplemental Figure 10: Ingenuity Pathway Analysis of the ZMEL1 expression signature showing core enriched networks. Supplemental Figure 11: Heatmap of metastatic spread over 14 days when cells are transplanted dorsally. Supplemental Figure 12: Histologic assessment of fish transplanted with ZMEL1-GFP cells Supplemental Figure 13: Histology of the kidney marrow from a stable transgenic mitfa-BRAFV600E;p53-/- melanoma bearing fish. Supplemental Figure 14: Derivation of the µ score for quantifying metastatic burden Supplemental Figure 15: Calculation of the metastasis initiating cell (MIC) frequency Supplemental Figure 16: Schematic overview of bright field image processing. Supplemental Figure 17: Determining pixel intensities in the transformed images. Supplemental Figure 18: Methods for segmentation of GFP images. Supplemental Figure 19: Methods for clustering of close objects. Supplemental Figure 20: Methods for separating merged tumors/metastases.