bluuebunny/crossref_metadata_2025 huggingface dataset:
XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway
Authors: Zhu Xin-Lin , Hu Dong-Ying , Zeng Zhao-Xiang , Jiang Wei-Wei , Chen Tian-Yang , Chen Tian-Cheng , Liao Wan-Qing , Lei Wen-Zhi , Fang Wen-Jie , Pan Wei-Hua
Published: September 2023

Diabetes and associated complications represent major global public health issues which are associated with impaired quality of life and premature death. Although some diabetic complications have decreased in the developed world, the majority are still prevalent, with an increasing trend in the developing world. Currently used therapies are mainly ‘glucocentric’, focusing on the optimization of glycemic control to prevent, delay or manage diabetes-associated complications- other common comorbidities, such as dyslipidemia and hypertension are often underestimated. Although a number of novel therapeutic approaches have been reported recently, some of them have not received comparable attention in relation to either further studies or potential clinical implementation. This editorial briefly discusses some recent therapeutic approaches to the prevention and management of diabetes and its associated complications, as well as potential directions for future research and development in this area.
Impact of Passive Pre-Chamber Nozzle Diameter on Jet Formation
Patterns and Dilution Tolerance in a Constant-Volume Optical
Engine
Authors: Lee Dong Eun , Iyer Claudia , Wooldridge Steven , Qiao Li , Yi Jianwen J.
Published: September 2023

Pre-chamber jet ignition technologies have been garnering significant interest in
the internal combustion engine field, given their potential to deliver shorter
burn durations, increased combustion stability, and improved dilution tolerance.
However, a clear understanding of the relationship between pre-chamber geometry,
operating condition, jet formation, and engine performance in light-duty
gasoline injection engines remains under-explored. Moreover, research
specifically focusing on high dilution levels and passive pre-chambers with
optical accessibility is notably scarce. This study serves to bridge these
knowledge gaps by examining the influence of passive pre-chamber nozzle diameter
and dilution level on jet formation and engine performance. Utilizing a modified
constant-volume gasoline direct injection engine with an optically accessible
piston, we tested three passive pre-chambers with nozzle diameters of 1.2, 1.4,
and 1.6 mm, while nitrogen dilution varied from 0 to 20%. With the help of
high-speed imaging, we captured pre-chamber jet formations and subsequent flame
propagation within the main chamber. Our novel findings reveal that asymmetric
temporal and spatial jet formation patterns arising from pre-chambers
significantly impact engine performance. The larger-nozzle-diameter pre-chambers
exhibited the least variation in jet formation due to their improved scavenging
and main mixture filling processes, but had the slowest jet velocity and lowest
jet penetration depth. At no dilution condition, the 1.2 mm-PC demonstrated
superior performance attributed to higher pressure build-up in the pre-chamber,
resulting in accelerated jet velocity and increased jet penetration depth.
However, at high dilution condition, the 1.6 mm-PC performed better,
highlighting the importance of scavenging and symmetry jet formation. This study
emphasizes the importance of carefully selecting the pre-chamber nozzle
diameter, based on the engine’s operating conditions, to achieve an optimal and
balanced configuration that can improve both jet formation and jet
characteristics, as well as scavenging.
Revisiting actors’ role in circular economy governance: A case of electric vehicle waste batteries in South Korea
Authors: Lee Youhyun , Kim Minjeong , Kim Kyoungmin
Published: September 2023

An increase in the number of electric vehicle (EV) waste batteries has driven the growth of the waste battery market. In the EV battery industry, South Korea has demonstrated excellent output in battery production but poor output in waste battery reuse and recycling. To determine appropriate waste battery use, primary governance actors should establish their role and lead the early stage of the industrial ecosystem. Herein, we elucidated the appropriate role of each circular governance actor in EV waste batteries using the South Korean case. We used the analytic hierarchy process, a semiquantitative method, and included 37 circular economy experts. For the first class, the firm is the most important actor in the circular governance of waste batteries, with a weight of 0.404, followed by the central (0.375) and local (0.221) governments. For the second class, the reuse industry (0.167) requires more attention than the recycling industry (0.133). Because many countries worldwide interested in the waste battery market have yet to begin the implementation stage, analyzing South Korea’s case can offer practical insights for countries aiming to expand their waste battery market with a clear policy orientation towards carbon neutrality or net-zero emissions and strong policy actor leadership.
The Development of Digital Competencies in Pre-Service Teachers
Authors: Marais Elma
Published: September 2023

Even before the Covid-19 pandemic created a historic pivotal moment for teacher training programmes on a global scale, the development of digital competencies has been regarded as a focal point for teachers. Tertiary institutions had just become accustomed to including technology in their curricula when Covid-19 forced a critical re-evaluation of the current practice. In a mere matter of days, the use of technology was not only a point for discussion anymore; it was lived. The ability of teacher educators to teach with technology had a direct impact on student success. Connectivity, access to suitable devices and sustainable training and support were now important considerations for teacher educators. The harsh reality soon became clear: Although some tertiary institutions could support pre-service teachers regarding access, connectivity and suitable devices, many students lacked the digital competencies to use the technology required for academic progress and success. It is evident that, in post-Covid-19 academia, the enhancement of digital competencies will remain a priority for teacher training programmes. The integration of digital competencies with content and pedagogical knowledge is essential for the successful training of future teachers. This article thus reflects on the efforts of a tertiary institution in South Africa to address the inclusion of technology in its curriculum through newly developed content that focuses on the enhancement of digital competency. Recommendations indicate that the effective inclusion of technology and digital competencies does not have to include major curricular changes but should rather become embedded within modules such as teaching practice.
Peran Guru Pendidikan Agama Kristen Dalam Pembentukan Karakter Siswa Menurut H.A.R. Tilaar
Authors: Anderson Ndolu  , Malau Maya , Manik Novida Dwici Yuanri , Iswahyudi Iswahyudi
Published: September 2023

Christian religious education has a goal, namely, to enable people to live as Christians, namely, to live according to the Christian faith. The role of Christian religious educators is to lead people out of darkness into the Kingdom of God in Jesus. In the scriptures we find a vision of God's own plan for all mankind and creation, greetings to which Jesus the great teacher teaches His good news. It is hoped that Christian religious education teachers can carry out their duties with a sense of responsibility in accordance with educational goals and create a generation that has noble character, is responsible and has the character of Christ. The role of this Christian religious education teacher also raises a big theme in character education written by the nation's educator H.A.R. Tilaar who provides character education to strengthen the character of local culture. The purpose of this study was to determine the extent of the role of Christian religious education teachers in shaping the character of students according to H.A.R. Tilaar. Christian teachers form good characters to live in God. Living in God is not just an outward appearance, but living in God through living characters, works and thoughts that lead to God's words. The implication of a character who loves God is directly related to the character-building role of Christian education.
 
Pendidikan agama Kristen memiliki tujuan yaitu untuk memampukan orang-orang hidup sebagai umat Kristen, yakni hidup sesuai iman Kristen. Peran pendidik agama Kristen adalah untuk menuntun orang-orang keluar dari kegelapan menuju Kerajaan Allah di dalam Yesus. Dalam kitab suci kita mendapatkan visi rencana Allah sendiri bagi seluruh manusia dan ciptaan, salam kesinambungannya Yesus sang guru agung mengajarkan kabar baik-Nya. Diharapkan guru pendidikan agama Kristen mampu melaksanakan tugasnya dengan rasa tanggung jawab sesuai dengan tujuan pendidikan dan menciptakan generasi yang berakhlak mulia, bertanggungjawab dan memiliki karakter Kristus. Peran guru pendidikan agama Kristen ini juga mengangkat tema besar dalam pendidikan karakter yang dituliskan oleh pendidik bangsa H.A.R. Tilaar yang memberikan pendidikan karakter menguatkan karakter budaya lokal. Tujuan penelitian ini adalah untuk mengetahui sejauh mana peran guru pendidikan agama Kristen dalam pembentukan karakter peserta didik menurut H.A.R. Tilaar. Guru Kristen membentuk karakter yang baik untuk hidup dalam Tuhan. Hidup dalam Tuhan bukan hanya sekadar penampakan luar, tetapi hidup dalam Tuhan melalui karakter hidup, karya serta pemikiran yang mengarah pada firman Tuhan. Implikasi dari karakter yang mengasihi Tuhan secara langsung terkait pada peran membangun karakter dari pendidikan Kristen.
Manajemen Pembelajaran Dalam Meningkatkan Perkembangan Kognitif Anak Usia Dini
Authors: Halawa Solingkari , Sni Seoni , Zendato Petrus Damai , Tanasyah Yusak
Published: September 2023

Learning management is an important thing in the process of teaching and learning activities, learning management influences student achievement in academic and non-academic activities. The purpose of this study is based on learning management to improve early childhood cognitive abilities by using the storytelling method and the question-and-answer method. This type of research is the bibliography, the data collected in this study are two types of data, namely primary data, and secondary data. Data obtained from library research (library). The data collection technique used by this researcher is a literature study. The data analysis technique in this study used qualitative analysis techniques in a deductive way. The research results obtained that the storytelling method and the questioning method play an important role in improving the cognitive development of early childhood which can make it easier for children to carry out teaching and learning activities.
  
Manajemen pembelajaran merupakan hal penting dalam proses kegiatan belajar mengajar, manajemen pembelajaran berpengaruh terhadap prestasi peserta didik dalam kegiatan Akademik dan non akademik. Tujuan penelitian ini Berdasarkan manajemen pembelajaran untuk meningkatkan kemampuan kognitif anak usia dini dengan menggunakan metode bercerita dan metode Tanya jawab, Jenis penelitian ini adalah bibliografi, data yang dikumpulkan dalam studi ini adalah dua jenis data yaitu data primer dan data sekunder. Data diperoleh dari riset kepustakaan (library). Teknik pengumpulan data yang digunakan peneliti ini adalah studi kepustakaan. Teknik analisis data pada penelitian ini dengan menggunakan teknik analisa kualitatif dengan cara deduktif. Hasil penelitian yang diperoleh bahwa metode bercerita dan metode bertanya sangat berperan penting dalam meningkatkan perkembangan kognitif anak usia dini dapat memudahkan anak dalam melakukan kegiatan belajar mengajar.
Strategi Pendidikan Agama Kristen Dalam Masyarakat Majemuk Di Sekolah
Authors: Ratu Artika , Tanasyah Yusak , Zusanna Dian Paskarina , Sari Anita Irama
Published: September 2023

Christian religious education requires a strategy. Christian Education is the education of Christian teachings that emphasize aspects of knowledge, attitudes, values, and even skills based on the Christian faith itself. With the strategy amid Christian Education, Christian Education can achieve the goals that should be implemented, especially among plural communities. A plural society is a society consisting of two or more elements that live independently without any renewal of each other in political unity. To make a Christian Education strategy in a plural society itself, we must know how the life of the plural society is first, after that we realize the Christian Education. Just as we can learn from the Lord Jesus' teaching about preaching the gospel in crowds. While doing the ministry, Jesus encountered various people with different characters. Not a few of them liked the teaching that Jesus preached, there were even some people who rejected the teaching and did not like Jesus, but despite the many challenges that Jesus experienced while doing the ministry, it did not prevent him from continuing to bind the gospel in various places. Finally, this study explains how to teach Christian Education in a pluralistic society by imitating the way Jesus did as mandated in Matthew 28:16-20.
 
Pendidikan Agama Kristen memerlukan yang namanya strategi. Pendidikan Agama Kristen adalah pendidikan ajaran-ajaran kekristenan yang menekankan pada aspek pengetahuan, sikap dan nilai-nilai bahkan keterampilan yang berdasarkan kepada iman Kristen itu sendiri. Dengan adanya strategi ditengah Penddidikan Agama Kristen tersebut membuat Pendidikan Agama Kristen tersebut dapat mencapai tujuan yang seharusnya terlaksanakan, terutama di kalangan masyarakat majemuk. Masyarakat majemuk adalah masyarakat yang terdiri dari dua atau lebih elemen yang hidup sendiri-sendiri tanpa adanya pembaruan satu sama lain dalam kesatuan politik. Untuk membuat strategi Pendidikan Agama Kristen dalam masyarakat majemuk itu sendiri, kita harus mengetahui bagaimana kehidupan masyarakat majemuk tersebut terlebih dahulu, setelah itu barulah kita merealisasikan Pendidikan Agama Kristen. Seperti halnya kita dapat belajar dari pengajaran Tuhan Yesus tentang memberitakan Injil ditengah orang banyak. Ketika melakukan pelayanan Yesus menjumpai berbagai orang dengan karakter yang berbeda-beda. Tidak sedikit dari mereka yang suka akan pengajaran yang Yesus sampaikan, bahkan terdapat sebagian orang juga yang menolak akan ajaran itu, dan tidak suka kepada Yesus, namun meskipun banyak sekali tantangan yang Yesus alami ketika melakukan pelayanan, hal itu tidak menghambatnya untuk terus memberikatan Injil di berbagai tempat. Akhirnya penelitian ini menjelaskan bagaimana melakukan pengajaran Pendidikan Agama Kristen ditengah masyarakat majemuk dengan mencontoh cara yang Yesus lakukan seperti diamanatkan dalam Injil Matius 28:16-20.
Peran Pendidikan Agama Kristen Melawan Diskriminasi Di Masyarakat Majemuk Indonesia
Authors: Barus Rona Ganta , Rahayu Khatrina Rintis Lintang , Tandana Ester , Liantoro Liantoro , Darmadi Darmadi
Published: September 2023

This article examines the role of Christian religious education in combating discrimination within a diverse Indonesian society. It explores the challenges posed by discrimination based on factors such as ethnicity, religion, and socio-economic status, and highlights the potential of Christian religious education to promote tolerance, respect, and inclusivity. The study investigates the principles and teachings of Christianity that emphasize equality, justice, and love for one's neighbor. It analyzes how Christian religious education can contribute to dismantling discriminatory attitudes and behaviors by instilling values of empathy, compassion, and acceptance. The article also discusses the importance of interfaith dialogue and collaboration in fostering understanding and breaking down barriers. Furthermore, it explores strategies for integrating Christian religious education within the Indonesian education system to address discrimination effectively. By nurturing a spirit of inclusivity and fostering respect for diversity, Christian religious education can play a vital role in creating a more harmonious and equitable society in Indonesia.
 
Artikel ini mengkaji peran pendidikan agama Kristen dalam memerangi diskriminasi dalam masyarakat Indonesia yang majemuk. Ini mengeksplorasi tantangan yang ditimbulkan oleh diskriminasi berdasarkan faktor-faktor seperti etnis, agama, dan status sosial-ekonomi, dan menyoroti potensi pendidikan agama Kristen untuk mempromosikan toleransi, rasa hormat, dan inklusivitas. Studi ini menyelidiki prinsip dan ajaran agama Kristen yang menekankan kesetaraan, keadilan, dan cinta sesama. Ini menganalisis bagaimana pendidikan agama Kristen dapat berkontribusi membongkar sikap dan perilaku diskriminatif dengan menanamkan nilai-nilai empati, kasih sayang, dan penerimaan. Artikel ini juga membahas pentingnya dialog dan kolaborasi antar agama dalam menumbuhkan pemahaman dan meruntuhkan sekat-sekat. Selain itu, bab ini mengeksplorasi strategi untuk mengintegrasikan pendidikan agama Kristen ke dalam sistem pendidikan Indonesia untuk mengatasi diskriminasi secara efektif. Dengan memupuk semangat inklusivitas dan menumbuhkan rasa hormat terhadap keberagaman, pendidikan agama Kristen dapat berperan penting dalam mewujudkan masyarakat yang lebih harmonis dan berkeadilan di Indonesia.
Katekismus Heidelberg
Authors: Timotius Timotius , Putrawan Bobby Kurnia
Published: September 2023

The Heidelberg Catechism’s opening question, with its emphasis on “consolation,” represents a profound theological and pastoral exploration of the human condition. It underscores the enduring quest for true comfort, rooted in faith in Jesus Christ, and offers solace and hope amid life’s uncertainties and the inevitability of death. Understanding the historical context, theological depth, and practical implications of this question enhances one’s appreciation for the enduring relevance of the Heidelberg Catechism in the Christian tradition. Further study and reflection on its teachings can enrich the spiritual journey of believers seeking lasting consolation in their faith. This article aims to explain that the first question in the Helderberg Catechism is Theocentric. This is because there are scholars who say that the Heidelberg Catechism is very people-centered because it starts with a question that seems to tend to emphasize human needs. The author uses the literature method in this study. The final result of this study the author will show that the Helderberg Catechism is Theocentric, not People-Centered because the first question in the Helderberg Catechism is based on the awareness that God is the true source of comfort so that Christians only want to seek true comfort from God.
 
Pertanyaan pembuka Katekismus Heidelberg, dengan penekanannya pada "penghiburan", mewakili sebuah eksplorasi teologis dan pastoral yang mendalam tentang kondisi manusia. Katekismus ini menggarisbawahi pencarian abadi akan penghiburan sejati, yang berakar pada iman kepada Yesus Kristus, dan menawarkan penghiburan serta pengharapan di tengah ketidakpastian hidup dan keniscayaan kematian. Memahami konteks historis, kedalaman teologis, dan implikasi praktis dari pertanyaan ini akan meningkatkan apresiasi seseorang terhadap relevansi abadi Katekismus Heidelberg dalam tradisi Kristen. Studi lebih lanjut dan refleksi atas ajaran-ajarannya dapat memperkaya perjalanan spiritual orang-orang percaya yang mencari penghiburan yang kekal dalam iman mereka. Artikel ini bertujuan menjelaskan bahwa pertanyaan pertama dalam Katekismus Helderberg bersifat Theosentris. Hal ini dikarenakan ada sarjana yang mengatakan bahwa Katekismus Heidelberg tersebut sangat people-centered karena memulainya dengan pertanyaan yang terkesan cenderung menekankan kebutuhan manusia. Penulis memakai metode literatur dalam penelitian ini. Hasil akhir dari penelitian ini penulis akan menunjukkan bahwa  Katekismus Helderberg bersifat Theosentris bukan People Centered karena pertanyaan pertama dalam Katekismus Helderberg didasarkan atas kesadaran bahwa Allah adalah sumber penghiburan sejati sehingga orang Kristen hanya mau mencari penghiburan sejati dari Allah.
Automated Assessment of Knowledge and Skills at the National Russian Therapy Olympiad with International Participation in 2023
Authors: Lopatin Z. V. , Timchenko V. V.
Published: September 2023

The development of modern systems and technologies creates new requirements for the education system every day, provides new opportunities for the development of educational methods, consumer coverage and data science. The experience gained as a result of the transfer of the Therapy Olympiad in 2021 to a remote format proved its success and prompted the development of the Olympiad in this direction. On March 21–22, 2023, the III National Russian Therapy Olympiad with international participation in online format was organized. As a result, 2,120 students, residents and schoolchildren from Russia, Uzbekistan, Kazakhstan, Belarus, Kyrgyzstan, Tajikistan, Azerbaijan, and India took part in the Olympiad. This article analyzes the Olympiad in order to study the possibility of conducting an automated assessment of knowledge and skills formed by students of 4–6 courses of specialty and residents of the therapeutic profile and other medical specialties. The following evaluation tools were used: knowledge testing using a distance learning system and assessment of practical skills using a Dimedus computer virtual on-screen patient simulator. The analysis of the results showed that the base of the formed test mini-cases and clinical cases is valid, reliable and can be used for automated assessment of knowledge and skills of students in specialty and residency programs of therapeutic profile. Statistical data and feedback data showed the involvement in the process and the interest of students in the chosen assessment format.
Intermediate Evaluation of the Work of the Simulator Interface Radiumsim Focus Group of Doctors in Practical Preparation for Accreditation in the Section Radiology
Authors: Sadykova K. I. , Sayfullina E. I.
Published: September 2023

The high level of professional training, technical skill and practical skills of the doctor acquired on the simulator of X-ray and magnetic resonance RadiumSim studies increase the quality of medical X-ray diagnostic care. A focus group of radiologists evaluated the uniqueness and effectiveness of the Radius simulator, as well as indicated the wishes and changes in the formation of the interface (including the designer of medical protocols and conclusions of CT studies) on the RadiumSim simulator. The use of the simulator of X-ray and magnetic resonance RadiumSim studies with additions of scenarios of various pathologies is recommended for accreditation of specialists in the field of radiology, as well as for practical training and training in the organization of independent work of students, residents and radiologists.
Medico-Legal Cases: An Overview
Authors: Sarla Gurmeet Singh
Published: September 2023

A Medico-Legal Case can be defined as a case of injury or ailment in which investigations by the law-enforcing agencies are essential to fix the responsibility regarding the causation of the injury or ailment. Once the attending doctor decides to treat the case as Medico Legal Case, immediately he is required to inform the jurisdictional police as provided under Section 39 of Criminal Procedure Code, failure to do so, may result in a prosecution under Sections 176 or 202 of Indian Penal Code. Based on the report, police visits the patient to verify details mentioned in Medico-Legal Case. If there is subsequent death of patient or if the relatives wish to take a legal action against the offender, then based on the Medico-Legal Report, a First Information Report is registered under the relevant Indian Penal Code section. Medical practitioners share the responsibility of action against crime by supporting the justice system. The best way for a medical practitioner to achieve this is by proper examination of victims and/or perpetrators, and completing the legal documents meticulously. Medico-legal documentation is more than the compilation of a medico-legal report. Inappropriate completion of medico-legal documentation may necessitate the practitioner having to explain the documentation to make it understandable to the court.
Optimization of medium and media components for maximum biomass of Halobacterium salinarum NRC-1 using Response Surface Methodology
Authors: Patil Divya , Vinod Bhoomika , RV Kavitha
Published: September 2023

Often, biotechnological advances are hindered by low growth rate of microorganisms utilized in the process, making optimal design of culture media a crucial aspect to consider in the biotechnology field. Materials and Method: Optimization of media components for growth and biomass production of Halobacterium salinarum NRC-1, our organism of interest, was carried out using response surface methodology, a statistical approach to optimize and improve the performance of a process by analyzing the relationships between input variables and output responses. A linear model was estimated and media components were determined based on the linear regression equation generated by the model. The variables chosen were casein enzyme hydrolysate, yeast extract, arginine, and peptone. Results & Discussion: An optimum result for the four variables was predicted based on the experimental response, which is 7.5 g/L of casein enzyme hydrolysate and yeast extract each, and 5.0 g/L each of peptone and arginine. The optimized medium reduced the time required for the cell culture to attain stationary phase, and showed a significant increase in the amount of biomass obtained as compared with that in standard media.
Revisiting SARS-CoV-2: Evolution, polymorphism and compatibility with human tRNA pool in a lineage over a month
Authors: Victor Manish Prakash , Das Rohit , Ghos Tapash Chandra
Published: September 2023

Introduction: The present study presents a comparative analysis of SARS-CoV-2‟s survival capacity in its human host in an area within a month. Materials and Methods: Codon usage bias study has been carried using Emboss package and evolutionary study has been carried using pn/ps packages in python and R for statistical analysis. Results: The virus has overlapping genes exhibiting a high codon usage bias and optimization with human Lung housekeeping genes. Viral ORFs have near values of minimum folding energies and codon adaptation index with mRNAs of the human Lung housekeeping genes. Then too, viruses showed a greater expression capacity. Polymorphism is in the virus for ORF1ab, surface glycoprotein and nucleocapsid phosphoprotein ORFs. Non-synonymous mutations have shown non-polar substitutions. Out of the twelve mutations nine are for a higher t-RNA copy number. Synonymous mutation simulation mimicking evolution revealed fitter newer strains. Conclusion: Through this study we have explained the inherent codon adaptation of SARS-CoV-2 with human tRNA pool and how the virus shows polymorphism in-order to keep up with its infectious capacity. Hence, giving an insight into viral rapid adaptability.
Postoperative pediatric cerebellar mutism syndrome: A literature review
Authors: Ballestero Matheus , Pongeluppi Rodrigo Inácio , Santos de Oliveira Ricardo
Published: September 2023

Introduction: Postoperative pediatric cerebellar mutism syndrome (POPCMS) is a significant complication observed after posterior fossa surgery for tumors, particularly in pediatric neurosurgery. This paper presents a literature review on the physiopathology, diagnosis, treatment, and long-term outcomes of POPCMS.

Methods: A systematic review following PRISMA guidelines, searching for articles published in PubMed, Web of Science, and Lilacs in the last ten years. Inclusion criteria involved studies on human subjects under 18 years of age, focusing on the pathophysiology, diagnosis, treatment, and outcome of POPCMS.

Results: The review identified 34 studies on POPCMS for final inclusion. Preoperative risk factors commonly associated with cerebellar mutism included midline tumor location, diagnosis of medulloblastoma, younger age at diagnosis, preoperative language impairment, brainstem infiltration, and tumor histology. The SHH subgroup was found to reduce the risk of CMS. Diagnostic criteria for POPCMS included language impairment, emotional lability, hypotonia, oropharyngeal dysfunction, dysphagia, cerebellar motor syndrome, cerebellar cognitive affective syndrome, and brainstem dysfunction. Treatment approaches varied, with medications showing potential benefits. Rehabilitation options for speech and language deficits were limited. Cognitive remediation programs showed promise in improving academic achievement and attention. A significant proportion of patients experienced clinical improvement. 

Conclusion:  POPCMS remains a challenging complication following posterior fossa surgery. Further research is needed to develop standardized diagnostic criteria, effective treatments, and rehabilitation strategies to improve long-term outcomes for patients with POPCMS.
Cerebellar Mutism after posterior fossa tumor surgery: is it predictable, preventable, treatable?
Authors: Jucá Carlos Eduardo Barros , Benevides Lima Gabrielle , Munhoz Pâmella Christine de Souza , De Andrade Patrícia Pereira , Ribeiro Francisco Gleison Albuquerque , Lopes Júlia Praciano
Published: September 2023

Introduction: Posterior fossa tumors pose challenges in pediatric neurosurgery and can lead to complications such as cerebellar mutism, affecting speech and motor abilities. This study aims to describe the evolution of cerebellar mutism and identify relevant factors in its pathophysiology and prognosis.
Methods: A review was conducted on three cases of children who underwent surgery for posterior fossa tumors by the same surgical team and developed postoperative cerebellar mutism. The study analyzed preoperative clinical presentation, mutism manifestation, and recovery. Additionally, a literature review was performed on the emergence, evolution, and prognosis.
Results: Case 1 involved a 3-year-old girl with medulloblastoma who experienced mutism, behavioral changes, and self-mutilation after surgery. Symptoms resolved after one month but recurred with a subsequent operation, resolving again after a month. Case 2 featured a 15-year-old girl who developed severe posterior fossa syndrome, including mutism, dysarthria, aphasia, and motor impairments. With support care, she gradually improved over a year. Case 3 involved a 4-year-old boy with cerebral palsy and a posterior fossa tumor. He experienced akinetic mutism, resolved over time with rehabilitation therapies.
Discussion: Cerebellar mutism following posterior fossa surgery has implications for patient recovery. It primarily involves impairment of cerebellar outflow pathways rather than direct brainstem or cortical lesions. Identifying at-risk patients remains challenging, though younger age and specific tumor characteristics may increase the likelihood of mutism. Rehabilitation, including physical and speech therapies, plays a crucial role in promoting recovery. Effective communication and support for patients and their families are essential during the recovery process.
El discurso estudiantil en el día de la reapertura de la Universidad del Zulia
Authors: Rincón Finol Imelda , Ortega Sheila , López Gustavo
Published: September 2023

Este trabajo de investigación sirve de presentación del Número 41 de la Revista de la Universidad del Zulia, publicación científica que forma parte del patrimonio histórico de esta institución universitaria, por lo que está adscrita a la Cátedra Libre Historia de la Universidad del Zulia. El objetivo del artículo consiste en identificar la visión política del discurso pronunciado por el Bachiller José Antonio Borjas, durante la reapertura de la Universidad del Zulia, el 01 de Octubre de 1946. La reapertura de esta universidad implicó todo un proceso histórico, cuyos antecedentes involucra la época de la colonización hispánica, extendiéndose hasta la fundación del Colegio Nacional de Maracaibo, instalado el 19 de abril de 1837, siendo el antecedente más inmediato para la creación e instalación de la Universidad del Zulia, el 11 de Septiembre de 1891. Entre las conclusiones destaca la coincidencia presente en el discurso estudiantil pronunciado por el bachiller José Antonio Borjas en el acto de la Reapertura de la Universidad del Zulia, con el discurso del Rector Jesús Enrique Lossada, donde ambos valoraron la reinstalación de la universidad como un logro de la Revolución del 18 de Octubre de 1945 en Venezuela.
The Impact of Digitalization of Education on the Development of Key Teacher Competencies
Authors: Dyka Natalia , Tretiak Olha , Horobets Svitlana , Yakunin Yaroslav , Shopina Maryna , Tsybulska Svitlana
Published: September 2023

The aim of the study is to identify the relationship between the digital competence of a higher school teacher and creativity, critical thinking, communicative, subject methodical, and communicative competence. The main research methods included testing to identify the level of digital competence, creativity, and critical thinking, as well as the interview to determine the level of subject methodological competence. The results of the study indicate that the medium level of the teacher competencies dominates. The level of teachers’ digital, subject methodological, communicative competencies, creativity, and critical thinking decrease in persons with 16-25 years of work experience. Digitalization of education most significantly affects the development of communicative and subject methodological competence. The relationship between digitalization and professional competencies is more significant among teachers with 1-15 years of work experience. The obtained results can be used to improve existing educational programmes for teacher training. The prospects for further research include the creation and verification of programmes of formative experiments aimed at clarifying the causal relationship between the digitalization of education and the development of the professional competence of higher school teachers
Intención emprendedora en estudiantes de Educación Superior
Authors: Reyes-Aceves Fanny Yumayra , Luna-Andrade Andrés Antonio , Ramos-López Leonardo
Published: September 2023

El tema de emprendimiento se ha considerado una alternativa para identificar el desarrollo y crecimiento económico de una región. Por lo tanto, resulta importante conocer la Intención Emprendedora (IE) de los estudiantes universitarios, con el fin de identificar la perspectiva de emprendimiento de los alumnos, y en este sentido gestionar recursos necesarios para que los profesionistas cumplan con las competencias básicas que el mercado laboralmente demanda. Por ello, el objetivo de la presente investigación es realizar un diagnóstico sobre la IE de estudiantes de educación superior, buscando aportar información desde la visión de los estudiantes. Se realizó un estudio cuantitativo, no experimental, transaccional y una investigación correlacional-causal. Se utilizó la Teoría del Conocimiento Planificado (TCP), a las variables que integran esta teoría se añadió la variable Educación Emprendedora (EE). Se encontró que las variables deseabilidad percibida, factibilidad percibida y normas sociales, aportan al desarrollo de la IE, por el momento la EE no arroja resultados significativos, por lo que se propone tomar medidas respecto a la capacitación docente, los planes de estudio que promuevan el emprendimiento y la realización de actividades extracurriculares que den fuerza al tema.
Challenges of Workplace Mobbing Prevention in General Education Schools
Authors: Vveinhardt Jolita , Jakucionyte Ieva
Published: September 2023

Mobbing in general education schools goes beyond the organization, and not only the internal environment of schools but also a wider social context must be evaluated in creating prevention programs. Therefore, this study aims to review and highlight the specific challenges of mobbing prevention in general education institutions. The research was conducted using a semi-systematic review approach. First, a list of relevant terms, which were used to select thematically related articles in scientific databases, was formed. This was followed by reading abstracts and selectingarticles for further analysis, which enabled to distinguish relevant categories of prevention challenges. The study has shown that the main challenges arise due to the used management models, inadequate responses of the school administration, the lack of information about mobbing and procedures for solving this problem as well as personal characteristics of the victim and the specific social context. A systematic approach is needed to create prevention programs and conduct research in general education institutions, which would allow not only to evaluate individual and organizational aspects but also to predict the threats arising in the school’s social environment and the ways to minimize them.
The Human Rights and Freedoms in Constitution of Romania of 1866
Authors: Kozar Yurii , Popenko Yaroslav , Sergiіenko Tetiana , Venger Olga , Yeremieieva Irina , Holovii Liudmyla
Published: September 2023

The purpose of the article is the analysis of the provisions of the first Constitution of Romania of 1866 in terms of guaranteeing of Human Rights and freedoms by the state. The article points out that the adoption of the Constitution of 1866 became a fateful state legal act for the entire Romanian people, since it meant a radical change in the ratio of external and internal factors in the state-building process of the Romanian state. To achieve this goal, general scientific and special-scientific methods of cognition were used, in particular, dialectical-legal-comparative, legal-formal. It has been determined that the accepted Constitution in 1866 in terms of guaranteeing Human Rights and freedoms has had a truly liberal character and has become the progressive state-legal act for the state-building process of Romania; the need to follow the norms of the Basic Law gradually have made constitutionalism as the form of thinking, which has contributed to the further expansion of democratic rights and freedoms and the development of the democratic views in the country.
La universidad ecuatoriana y el desarrollo de habilidades comunicativas en inglés
Authors: Andrade Mendoza José Luis , Vallejo Barreno Carina Fernanda , Lechón De La Cruz Marjory Estefanía
Published: September 2023

Cuando se trata de la obtención de habilidades comunicativas en inglés, su importancia no puede discutirse. Quienes realizan estudios de educación superior requieren tener las potencialidades para mantenerse actualizado, los alumnos para aprender y, los docentes para enseñar. Así, este artículo se plantea como objetivo, una lectura crítico-hermenéutica de las circunstancias actuales en las que se desarrolla el proceso enseñanza aprendizaje del idioma inglés en el contexto universitario de Ecuador. Parte de un diseño documental que recaba información de las estrategias pedagógicas en la enseñanza del inglés, considerando la importancia que tiene esta lengua en el proceso de prosecución intelectual y laboral de los estudiantes universitarios. Es sabido que, a raíz de algunos cambios curriculares ocurridos en la segunda década del siglo XXI, el sistema de educación ecuatoriano incluye la enseñanza del inglés en la Educación General Básica y en Bachillerato, algo que impulsa su valoración en niveles superiores. En el ámbito universitario, el análisis de la literatura sobre el tema y la lectura crítica hermenéutica deja ver que el aburrimiento de los estudiantes y su desmotivación, tiene entre otras causas, la poca innovación de los docentes, quienes tienden a trabajar en función de la lectura de libros- textos con pocos incentivos para un aprendizaje significativo y colaborativo. En tanto, se hace urgente que los profesores introduzcan nuevos métodos y estrategias a nivel de la formación universitaria que apunte al desarrollo de competencias comunicativas para potenciar el progreso intelectual y socioproductivo de los estudiantes y egresados de las universidades ecuatorianas.
Estudiante de medicina: sus ideas y escritura
Authors: Estrada José Ramón Olivo , Torres Carmelina Montaño , Nava Bernabé Ríos
Published: September 2023

Presentamos nuestra vivencia pedagógica en la unidad de aprendizaje de Socioantropología de la Salud (SaS) con los estudiantes de los grupos A y B de primer ingreso a la carrera de Médico Cirujano (ciclo escolar 2016-2017) en la Unidad Académica de Medicina (UAM) de la Universidad Autónoma de Nayarit (UAN) en su incursión a los laberintos de la lectura y escritura académicas. De nuestra intervención resaltamos el trabajo realizado durante la implementación del taller y la elaboración de la autobiografía. Nuestro propósito fue colaborar mutuamente para la comprensión y puesta en práctica de diversas habilidades, destrezas y conocimientos en la lectura y producción de textos académico-científicos.
FLEXIBILITY IN ASSEMBLY PLANNING THROUGH PRODUCT DESIGN IN INDUSTRIES
Authors:   Mechanical and Aerospace Engineering Department,University of Uyo, Nigeria, Akpan W.A. , Beshel S.I. ,   Mechanical and Aerospace Engineering Department,University of Uyo, Nigeria, Usungurua E. O. ,   Mechanical and Aerospace Engineering Department,University of Uyo, Nigeria
Published: September 2023

Manufacturing processes and equipment that can handle preconceived and emergency changes with low penalty in time, effort, cost and performance are required in the industries to accelerate introduction of new product, handle breakdown of systems and modification of already existing products. Though there are several attempts on this research, especially in development of equipment capable of handling industrial changes but the results are still not satisfactory. Contributing to achieving a Flexible assembly system. Compensative flexibility Model/Approach was carried out in this research to handle Flexible Assembly system through product design. The model developed performed: generation of assembly sequence, schedule and balancing for assembly planning at the product design stage, extracted product assembles requirements for product design at the conceptual stage to guide the designer; synchronized assembly system and product design and; modularized assembly system and product design. Transportation system of an Assembly system of an engine was simulated using ProModel Simulator and the result was remarkable. Also the design of IC engine using two variance; inline and V IC engines showed remarkable improvement in parts interchangeability and commonality with modularized design; 76% of the parts used in inline engine were also used in the V engine variance. Results from simulation runs with 8 automatic guided vehicle (AGV) in the system were observed, with the average time spent by parts in the system and the average time blocked were significant dropped as number of buffers and AGV were increased; the effect was more pronounced with 8 AGVs and 8 storage buffers in the system. The average (AVG) time blocked with 8 AGV and 1 storage buffer was 56.7 minutes and reduced to 0 minutes when the number of storage buffer increased to 8 with 8 AVGs, the percent reduction was 100 percent while AVG time in the system with one storage buffer was 59.34 minutes and reduced to 4.37 minutes with 8 storage buffers which is 96.9 percent reduction. The variation of number of vehicles and buffers reduced or increased the time component spent in the system. Thus, if correct workstation or assembly system resources are determined and designs are modularised, more articles will be introduced to the market, time to market will reduce, many variances will be produced and there will be reduction in the cost of production. The application of this technique is recommended for processing industry.
Psychoanalytic Reading of Decadence and Crisis in Ted Hughes’ “Relic” and T.S. Eliot’s “The Hollow Men”
Authors:   Department of English Language and Literature, North Western University, Khulna-9000, Bangladesh, Hasan Md Mehedi
Published: September 2023

This research employs psychoanalytic methods to explore themes of decadence and crisis in Ted Hughes’ “Relic” and T.S. Eliot’s “The Hollow Men”. Drawing from Freudian and Jungian theories, it delves into the psychological aspects to reveal expressions of the despair of modernity. The paper illustrates underlying psychological decay within the poems, examining subconscious motives, suppressed desires, and conflicts. Through this exploration, intricate psychological states contributing to perceptions of crisis come to light. Highlighting these literary pieces as reflections of contemporary turmoil, the poems expose the erosion of both individual and collective identities. By using the lens of psychoanalysis, a deeper understanding of the interplay between the human psyche and society emerges, offering insights into the profound implications of modern decadence and crisis. Ultimately, the application of psychoanalysis enriches comprehension of the connections between psychological intricacies and societal disintegration, shedding light on the significance of the poets’ selected works
Analysis of the Influence of Service Quality and Perceived Risk Based on Type of Consumer on Consumer Satisfaction and its Impact on Repurchase Intentions of Kebomas NPK Fertilizer After Centralization at PT Petrokimia Gresik
Authors:   Master of Management, Faculty of Economics and Business, Airlangga University, Chandra Budiman Muhammad , Kurniawati Masmira ,   Master of Management, Faculty of Economics and Business, Airlangga University
Published: September 2023

Optimization of all resources owned into an integrated whole, is the goal for cost efficiency in the company's operational processes. Centralization is an integration effort initiated to produce optimal shipping costs, one-stop integrated services, and better service speed than before. However, in a transformation it is necessary to measure and evaluate the progress of the transformation itself in order to make improvements that support centralization. This study aims to analyze the effect of Service Quality (X1) and Perceived Risk (X2) based on Consumer Type (Z) on Consumer Satisfaction (M) and their impact on Repurchase Intention (Y) of NPK Kebomas fertilizer after centralization at PT Petrokimia Gresik. This study used a survey method with 95 respondents randomly selected from NPK Kebomas fertilizer users. The results of the study show that Service Quality has a positive influence on Consumer Satisfaction in Repurchasing Intentions. Perceived Risk which is moderated by Consumer Type has a negative influence on Consumer Satisfaction in Repurchasing Intentions. Consumer Type have an influence on Perceived Risk. Distributors have a higher Perceived Risk than End Users. Based on the research results, it can be concluded that centralization has a good impact on the company, it's just that some suggestions for improvement are needed to accommodate the gap that originates from withdrawing responses from consumers in this study.