bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic variation in correlated regulatory regions of immunity
Authors: Avalos Diana , Rey Guillaume , Ribeiro Diogo M. , Ramisch Anna , Dermitzakis Emmanouil , Delaneau Olivier
Published: August 2022

Studying the interplay between genetic variation, epigenetic changes and regulation of gene expression in immune cells is important to understand the modification of cellular states in various conditions, including immune diseases. Here, we built cis maps of regulatory regions with coordinated activity – Cis Regulatory Domains (CRDs) – in neutrophils, monocytes and T cells. For this, we leveraged (i) whole-genome sequencing (WGS), (ii) chromatin immunoprecipitation sequencing (ChIP-seq), (iii) DNA methylation (450k arrays), and (iv) transcriptional profiles (RNA-seq) from the BLUEPRINT consortium, for up to 200 individuals.
Our study uncovers 9287, 7666 and 5480 histone CRDs (hCRDs) and 6053, 6112, 5701 methyl CRDs (mCRDs) in monocytes, neutrophils and T-cells, respectively. We discovered 15294 hCRD-gene and 6185 mCRD-gene associations (5% FDR). Only 33% of hCRD-gene associations and 37% of mCRD-gene associations were shared between cell-types, revealing the dynamic nature of regulatory interactions and how similarly located regulatory regions modulate the activity of different genes on different cell types. We mapped Quantitative Trait Loci associated with CRD activity (CRD-QTLs) and found that 89% and 70% of these hCRDs and mCRDs are under genetic control highlighting the importance of genetic variation to study the coordination of cellular regulatory programs. We found CRD-QTLs to be enriched in cell-type-specific transcription factor binding sites, such as SPI1, STAT3, RFX1, SOX4, ATF3 for neutrophils and monocytes and TCF4 and BCL11A for T-cells, in line ​​with the Human protein Atlas.
We integrated PCHi-C data, which showed that most significant associations discovered within gene-CRD associations and co-expressed genes associated with the same CRD, involving large genomic distances, tend to happen between genomic regions in close spatial proximity. Finally, we mapped trans regulatory associations between CRDs, which enabled the discovery of 207 trans-eQTLs across cell types. Overlapping our hits with trans eQTLs from eQTLGen Consortium meta-analysis in whole blood revealed 81 trans-eQTLs shared between the two studies. Overall, we show that mapping functional regulatory units using population genomics data allows discovering important mechanisms in the regulation of gene expression in immune cells and gain a greater understanding of cell-type specific regulatory mechanisms of immunity.
A Multi-Year Tropical Pacific Cooling Response to Recent Australian Wildfires in CESM2
Authors: Fasullo John , Rosenbloom Nan , Buchholz Rebecca
Published: August 2022

The coupled climate response to biomass burning emissions from the 2019/20 Australian wildfire season is estimated from the contrast between two 30-member ensembles using CESM2 initialized in August 2019: one of which incorporates observed wildfire emissions while the other does not. In response to the fires, a widespread increase in biomass aerosol burdens is simulated in the southern hemisphere through late 2019 and early 2020. Accompanying the increase is an enhancement of cloud albedo, particularly in regions of widespread stratocumulus clouds in the southeastern subtropical Pacific Ocean. The increase in albedo acts to cool the surface, dry the boundary layer, and reduce the moist static energy of the advected low-level flow into the deep tropics. It also cools the ocean locally and the currents that flow into the deep tropics. In response, the Intertropical Convergence Zone is found to migrate northward and sea surface temperature in the Niño3.4 region cools. A subsequent multi-year ensemble-mean cooling of the tropical Pacific is simulated through the end of 2021, suggesting an important contribution to the ongoing strong La Niña event.
Anomalous optical response of graphene on hexagonal boron nitride substrates
Authors: Toksumakov Adilet , Ermolaev Georgy , Tatmyshevskiy Mikhail , Klishin Yuri , Slavich Alexander , Begichev Ilya , Stosic Dusen , Yakubovsky Dmitry , Kvashnin Dmitry , Vyshnevyy Andrey , Arsenin Aleksey , Volkov Valentyn , Ghazaryan Davit
Published: August 2022

Graphene/hBN heterostructures can be considered as one of the basic building blocks for the next- generation optoelectronics mostly owing to the record-high electron mobilities. However, currently the studies of optical properties of graphene are limited to the standard substrates (SiO2/Si, glass, quartz) despite the growing interest in graphene/hBN heterostructures. This can be attributed to a challenging task of the determination of hBN’s strongly anisotropic dielectric tensor in the total optical response. In this study, we overcome this issue through imaging spectroscopic ellipsometry utilizing simultaneous analysis of hBN’s optical response with and without graphene monolayers. Our technique allowed us to retrieve the optical constants of graphene from graphene/hBN heterostructure in a broad spectral range of 250 - 950 nm. Our results suggest that graphene’s absorption on hBN may exceed the one of graphene on SiO2/Si by about 60%.
Scheduling and Energy Savings for Small Scale Embedded FreeRTOS-based Real-Time Systems
Authors: Oliveira Gessé , Lima George
Published: August 2022

Evaluating the effectiveness of system scheduling and energy savings in embedded real-time systems with low computing resources is the problem addressed in this paper. In such systems, the characteristics of the implemented scheduling policy play a relevant role in both schedulability and energy consumption. Ideally, the scheduling policy should provide higher schedulability bounds and low runtime overheads, allowing for better usage of available slack in the schedule for energy saving purposes.
Due its low overhead and simple implementation, the usual scheduling policy employed in real-time embedded systems is based on fixed priority (FPS). Under this scheme, as the priority of all system tasks are assigned at design time, a simple priority vector suffices to indicate the current ready task to run. System schedulability, however, is usually lower than that provided by dynamic priority schedulers (DPS) according to which task priorities are assigned at runtime. Managing dynamic priority queues incurs higher overheads, though. Deciding whether DPS is a possible choice for such embedded requires careful evaluation.
We evaluate two implementations of Earliest-Deadline First (EDF), a classical DPS, implemented in FreeRTOS running on an ARM-M4 architecture. EDF is compared against an optimal FPS, namely Rate-Monotonic scheduling (RMS). Further, two mechanisms for energy savings are described. They differ by the manner they compute the slack available in an EDF schedule, statically (SS-EDF) or dynamically (DS-EDF). These two approaches are experimentally evaluated. Results indicate that EDF can be effectively used for energy savings.
Model Misspecification of Log-Normal and Birnbaum-Saunders Distributions
Authors: Basu Suparna , Kundu Debasis
Published: August 2022

Model misspecification can be a serious issue in any lifetime data analysis. Assumption of the correct model is very important particularly in prediction for future observations and for estimating the tail probabilities of any lifetime distribution. In this paper we have considered the model misspecification of the log-normal and Birnbaum-Saunders distributions. These two distributions have striking similarities both in terms of the probability density functions and hazard functions, in certain range of parameter values, which makes it extremely difficult to detect the correct model. Hence, to identify the correct model, first the conventional method of ratio of maximized likelihood approach has been tried. The necessary theoretical results have been derived. Based on extensive simulations it has been observed that for certain range of parameter values the model misspecification can be quite high even for very large sample sizes. Some of the other methods like the ratio of maximized product of spacings and minimized Kolmogorov-Smirnov distance, have also been explored. But none of the method performs uniformly better than the other over the entire range of the parameter space. Some counter intuitive results have also been obtained. Hence, we finally conclude that it is extremely difficult to choose the correct model in case of log-normal and Birnbaum-Saunders distribution for certain range of parameter values. Finally, we have suggested a modified ratio of maximized likelihood approach, and the performances are quite satisfactory.AMS Subject Classifications: 62F10, 62F03, 62H12.
Reduced order model-inspired system identification of geometrically nonlinear structures
Authors: Ahmadi M. Wasi , Hill Thomas L. , Jiang Jason Zheng , Neild Simon A.
Published: August 2022

In the field of structural dynamics, system identification usually refers to building mathematical models from an experimentally-obtained data set. To build reliable models using the measurement data, the mathematical model must be representative of the structure. In this work, attention is given to robust identification of nonlinear structures. We draw inspiration from reduced order modelling to determine a suitable model for the system identification. There are large similarities between reduced order modelling and system identification fields, i.e. both are used to replicate the dynamics of a system using a mathematical model with low complexity. Reduced Order Models (ROMs) can accurately capture the physics of a system with a low number of degrees of freedom; thus, in system identification, a model based on the form of a ROM is potentially more robust. Nonlinear system identification of a structure is presented, where inspiration is taken from a novel ROM to form the model. A finite-element model of the structure is built to simulate an experiment and the identification is performed. It is shown how the ROM-inspired model in the system identification improves the accuracy of the predicted response, in comparison to a standard nonlinear model. As the data is gathered from simulations, system identification is first demonstrated on the high fidelity data, then the fidelity of data is reduced to represent a more realistic experiment. A good response agreement is achieved when using the ROM-inspired model, which accounts for the kinetic energy of unmodelled modes. The estimated parameters of this model are also demonstrated to be more robust and rely on the underlying physics of the system.
Impact of Human Resource Management Reform in Public Hospital on Work Performance and Work-home Conflicts of Physicians in China
Authors: Han Liping , Wang Xiaoyu , Zhu Yimei , Wang Fang , Liang Jing , Ye Beizhu , Zhu Xi , Wang Zixin , Liang Yuan
Published: August 2022

Background Although China's hospital human resource reform started more than ten years ago, studies on its impact on physicians’ work and life are relatively few. This study used data from a national survey of physicians in China to explore the impact of two aspects of human resource reform measures (namely MOES and EPEW) with work performance and work-family conflicts among physicians. Methods We conducted a national cross-sectional survey in 77 public hospitals across seven provinces in China between July 2014 and April 2015, and 2785 physicians involved in this study. Work performance included work engagement, career attrition and patient-centered care. Work-family conflicts were composed of affecting care for family, feeling guilty towards family and receiving complaints from family.RESULTS Participants with MOES only account for 20.25%, those with EPEW only account for 10.36% and those with MOES & EPEW account for 4.35%. After adjusted for potential confounders, compared with those who had no experience of human resource reform measures, participants who had experiences of MOES & EPEW were more likely to report positive work performance (pride in work: aOR = 4.35, 95% CI :2.60–7.28; enjoyment of work: aOR = 4.46, 95% CI :2.71–7.35; turnover intention: aOR = 0.40, 95% CI :0.25–0.65; early retirement: aOR = 0.35, 95% CI: 0.21–0.58; exhaustion: aOR = 0.50, 95% CI :0.31–0.81) and negative work-family conflicts (feeling guilty towards family: aOR = 0.45, 95% CI :0.2810.73; receiving complaints from family: aOR = 0.52, 95% CI :0.32–0.85). Analysis stratified by age ≥35y and <35y showed that the human resource reform measures would have a higher effect on participants age ≥35y compared with those age <35y. CONCLUSIONS The differences stratified by age would reveal that salary system reform may need to be accelerated further and employment system reform may need to be appropriately slowed down, and accordingly, perfecting spiritual incentives measures would be needed to overcome the decline of their effect over time in the future.
Solvent-free and long-cycling garnet-based lithium-metal batteries
Authors: Yu Jiameng , Zhang Chang , Wu Cong , Wei Ran , Chen Shaojie , He Yingjie , Hu Qilin , Liu Wei
Published: August 2022

Solid-state batteries using ceramic solid electrolytes promise to deliver enhanced energy density and intrinsic safety. However, the challenge of integrating solid electrolytes with electrode materials limits the electrochemical performances. Herein, we report a solvent-free ceramic-based lithium-metal battery with excellent performances at a wide temperature range of 45 to 100°C, enabled by inorganic ternary salt of extreme-low eutectic point. By using garnet electrolyte with molten salts at the electrolyte|cathode interface, the Li||LiFePO4 cells perform a long cycling stably with capacity retention of 81.4% after 1000 cycles at 1 C. High-voltage LiFe0.4Mn0.6PO4 cathodes also deliver good electrochemical performance. Specifically, commercial electrode pieces with high area capacities can be adopted directly in the quasi-solid-state lithium-metal batteries. These superior performances are ascribable to the low melting point, high ionic conductivity and good thermal/electrochemical stability of the ternary salt system. Our findings provide an effective method on fabrication of solid-state batteries towards practical applications.
Preoperative Intrathecal Morphine is Associated with Reduced Postoperative Pain, Agitation, and Delirium in Living Donor Kidney Transplantation Recipients
Authors: Lee Ja Eun , Lee Kyo Won , Gil Eunmi , Park Jae Berm , Kim Byung Jun , Kim Gaab-Soo
Published: August 2022

Postoperative delirium after organ transplantation can lead to increased length of hospital stay and mortality. However, prevention of postoperative delirium is challenging for transplant recipients due to their frailty and metabolic derangements associated with end-stage organ failure. Postoperative pain is an important risk factor for postoperative delirium, and pain management with intrathecal morphine (ITM) may mitigate postoperative delirium development. We evaluated if ITM reduces postoperative delirium incidence in living donor kidney transplant (LDKT) recipients. In this retrospective study, 296 patients who received LDKT between 2014 and 2018 at our university hospital were analyzed. Recipients who received preoperative ITM (ITM group) were compared to those who did not (control group). The primary outcome was postoperative delirium incidence based on Confusion Assessment Method for Intensive Care Unit results during the first four postoperative days. Delirium occurred in 2.6% (4/154) and 7.0% (10/142) of ITM and control groups, respectively. Multivariable analysis showed age (OR: 1.07, 95% CI: 1.01–1.14; P = 0.031), recent smoking (OR: 7.87, 95% CI: 1.43–43.31; P = 0.018), preoperative psychotropics (OR: 23.01, 95% CI: 3.22-164.66; P = 0.002) were risk factors of postoperative delirium while ITM was a protective factor (OR: 0.23, 95% CI: 0.06–0.89; P = 0.033). Preoperative ITM was independently associated with reduced post-LDKT delirium. This analgesic technique may be part of postoperative delirium prevention strategy in LDKT recipients.
A nomogram for predicting sclerotherapy response for treatment of lymphatic malformations in children
Authors: Wu Zhiping , Zou Yun , Fu Ronghua , Jing PingLiang , Yuan Hua
Published: August 2022

Purpose In this manuscript, we purposed to identify the prognostic factors for treatment of lymphatic malformations in children using polidocanol foam combined with pingyangmycin and to construct nomogram for predicting sclerotherapy response.Methods A retrospective analysis of 77 children having LMs underwent sclerotherapy using polidocanol foam combined with pingyangmycin under ultrasound display from January 2017 to April 2020 was done. The clinical response was graded as excellent (≥90%), good (≥50%, <90%), and poor (<50%). More than 50% was considered as acceptable response. Prognostic factors were identified by Pearson’s chi-square or Fisher’s exact test and multivariable logistic regression model was used to construct a nomogram to predict sclerotherapy response. The discrimination and calibration of nomogram were verified through the receiver operating characteristic cure and calibration plots.Results The mean number of treatment sessions was 3.1 (range, 1-6). Among 77 patients, 58 patients (75.3%) had excellent response to treatment (≥90%) and 68 patients (88.3%) had an acceptable response (≥50%, <90%). Clinical disfigurement (P = 0.014), skin discoloration (P = 0.040), morphological subtype (P < 0.001) and extent of the lesion (P < 0.001) correlated with clinical response to sclerotherapy in LMs. Sclerotherapy response was predicted through nomogram constructed in this study, which shows good calibration and discrimination. Also, focal lesion and macrocystic or mixed morphological subtype lesion were seen more often in lower number of treatment sessions among the patients with excellent response.Conclusions Acceptable response to sclerotherapy using polidocanol foam combined with pingyangmycin was achieved in majority of LMs in children with extremely low complication rates. Nomogram basing on the prognostic factors of sclerotherapy response for LMs in children was showed to possess an excellent performance to predicate the probability of LMs sclerotherapy response.
Welding Penetration and Mechanical Properties of Welded Joints of V-shaped Surface Grooves
Authors: Feng Meiyan , Weng Huajing , Yao Mingpu , Jiang Jibin , Chen Changrong , Lian Guofu
Published: August 2022

The work focused on the forming quality of surface-groove backing welds of gas metal arc welding (GMAW). The Box-Behnken design in response surface methodology (RSM) was used to explore the effects of welding voltages, welding currents, welding speeds, and surface radians on the properties of welded joints. The mathematical model was established among process parameters and response indices of welded joints. Experimental results showed that the unmelted gap decreased with the increased welding voltage, welding current, welding speed, and surface radian. Tensile strength increased with the increased welding voltage and welding speed and decreased after increasing with the increased surface radian. Elongation first increased and then decreased with the increased welding voltage, welding speed, and surface radian. Optimal process parameters were obtained by minimizing the unmelted gap and maximizing the tensile strength and elongation: welding voltage = 32 V; welding current = 224 A; welding speed = 32 cm/min; surface radian = 14/36π rad. The errors of the unmelted gap, tensile strength, and elongation were 1.71%, 5.69%, and 1.27%, respectively, by comparing the predicted and actual values. Research results have essential theoretic guidance for improving the penetration and mechanical properties of complex surface grooves welded joints.
Functional diagnosability of possibly uncertain systems through functional linear independence
Authors: Jauberthie Carine , Verdière Nathalie , Travé-Massuyès Louise
Published: August 2022

This paper resumes functional diagnosability of nonlinear dynamical systems as introduced in [1] and its extension to the set-membership framework named Set-Membership Functional Diagnosability [2]. This latter concept assumes that the magnitudes of the faults are unknown but belong to bounded sets. The two properties are based on the notion of functional signature formed of a functional residual vector. Contrary to conventional analyses of diagnosability, functional diagnosability analyses the behavior of the residuals in time for different faults are acting on the system. In [1], it was shown that identifiability of the model with respect to the faults is a sufficient condition for diagnosability. The same is true in the set-membership framework [2]. In this paper, we provide a much simpler sufficient condition that relies on functional linear independence [3] of the functional signatures. This result is illustrated with two examples through numerical simulations.
Learning curve of robot-assisted total knee arthroplasty and its effects on implant position in Asian patients: A prospective study
Authors: Jung Ho Jung , Kang Min Wook , Lee Jong Hwa , Kim Joong Il
Published: August 2022

Background
Robot-assisted total knee arthroplasty (r-TKA) can reportedly achieve a more accurate implant position than conventional total knee arthroplasty (c-TKA), although its learning curve is controversial. Moreover, there are few studies on Asians with different anatomical characteristics. This study aimed to determine the learning curve for r-TKA and compare implant positions between r-TKA and c-TKA according to the learning curve in Asian patients.
Methods
This prospective study included 50 consecutive c-TKAs (C group), followed by 50 consecutive r-TKAs using the MAKO robotic system (Stryker, USA). Cumulative summation analyses were performed to assess the learning curve for operative time in r-TKAs. Accordingly, the r-TKA cases were divided into initial cases (I group) and proficiency cases (P group). Femoral and tibial component positions in the coronal, sagittal, and axial planes and lower limb alignment were compared among all groups.
Results
r-TKA was associated with a learning curve for operative time in 18 cases. Operative time was significantly shorter in the C and P groups than in the I group, with no significant difference between the C and P groups. The I and P groups demonstrated fewer outliers regarding lower limb alignment, femoral component coronal position, axial position, and tibial component sagittal position than the C group, with no significant difference between C and P groups.
Conclusion
Operative time was not significantly different between r-TKA and c-TKA after the learning curve. Surgeons could expect more accurate and reproducible lower limb alignment and implant position with r-TKA in Asian patients regardless of the learning curve.
Preparation of Protoplasts from Populus (Populus × xiaohei T. S. Hwang et Liang) and Establishment of Transient Expression System
Authors: Yang Chengjun , Wang Kai , Li Jinbo , Liu Guanjun , Xu Zhiru
Published: August 2022

Poplar, as a typical woody plant, is an ideal raw material for the production of lignocellulose biofuel. However, the longer life cycle is not conducive to the rapid identification of poplar genes. At present, many model plants have used protoplasts for gene function identification and high-throughput analysis. In this paper, a simplified and efficient protoplast isolation and transient expression system of Populus (Populus × xiaohei T. S. Hwang et Liang) is described. Firstly, we proposed an efficient enzyme hydrolysis method for isolating protoplasts from leaves of Populus × xiaohei. Secondly, we further optimized the conditions of protoplast transformation mediated by PEG, and established an efficient transient expression system of protoplasts of Populus × xiaohei. Finally, the subcellular localization of three identified Dof transcription factors (PnDof19,PnDof20 and PnDof30) was also observed in the nucleus by using this scheme, which proved that the method was feasible. In general, this efficient method of protoplast isolation and transformation can be used for the study of protein subcellular localization and can be applied to other fields of molecular biology, such as protein interaction, gene activation and so on.
A risk model including eight tumor microenvironment-related genes for prediction of lung cancer prognosis
Authors: Wei Ming , Li Mengyun , Li Chenwei , Zhang Xu , Ma Hengde , Du Xiaohui , Wang Qi , Zhao Hui
Published: August 2022

Background
The tumor microenvironment (TME) plays a crucial role in lung cancer development and outcome. In this study, we constructed a novel risk model using TME-related genes to predict the prognosis of lung adenocarcinoma (LUAD).
Methods
TME-related genes were collected from the literature, and the LUAD transcriptome profile and clinical characteristics from patients were retrieved from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) as the training and validation cohorts, respectively. In the training cohort, K-mean Cluster and Kaplan–Meier curve analyses were performed to examine the association of the TME-related genes with LUAD, while univariate Cox regression and LASSO Cox regression analyses assessed the key genes to construct a predictive risk model for LUAD prognosis. This risk model was then confirmed in the validation cohort using Kaplan–Meier and receiver-operating characteristic (ROC) curve analyses and then compared with other models and LUAD TNM stage. The interaction of this predictive risk model of genes with immune-related genes was also assessed using CIBERSORT, TIMER, and GEPIA.
Results
After screening 760 TME-related genes, we established a risk model containing ANGPTL4, FUT4, CDC25C, FLNC, KRT6A, NEIL3, HS3ST2, and DAAM2 that independently predicted LUAD prognosis in TCGA data. ROC curve and C-index confirmed the usefulness of this risk model, and a nomogram that integrated this predictive risk model with age and TNM stages was more effective in predicting LUAD prognosis. The risk model was further confirmed using GEO data. Furthermore, the risk model of genes interacted with 11 types of immune cells and three immune checkpoint molecules (LAG3, PDL1 and TDO2) in LUAD.
Conclusion
We constructed a predictive risk model and a nomogram that integrated the predictive risk model with age and TNM stage to predict LUAD prognosis. This predictive risk model of genes could interact with immune checkpoint genes. Future studies are required to validate these data.
Intestinal malrotation in adult : a unique case combining parduodenal hernia and complete common mesentery
Authors: Barka Malek , Jarrar Mohamed Salah , Haouala Sirine , Hamila Fehmi , Youssef Sabri
Published: August 2022

Background :Intestinal malrotation is a rare congenital abnormality occurring in 0.2–1% of the population.Cases diagnosed in adulthood are even rarer, thus constituting a diagnostic challenge. Case presentation : we report a case of 43 year-old patient presenting with an exceptional combination of left paraduodenal hernia and complete common mesentery whose management was performed laparoscopically. Conclusion :This case documented a rare anatomic variant, combining two abnormalities of intestinal rotation diagnosed in adulthood.
Quantitative semiclassical analysis of ultracold weakly interacting bose gas trapped in optical boxes
Authors: Hassan Ahmed , Elbadry Azza , Mohammedein Adel M.
Published: August 2022

In this paper, the condensate fraction and the critical atom number and its corresponding critical temperature of condensate ultracold boson atoms trapped in optical box traps, are investigated. The semiclassical approximation is employed in this study. The boxes traps are modeled by a general power-law potential. The deviation of the boxes traps from an ideal boxes traps are discussed.The out come results furnish useful quantitative theoretical results for thefuture BEC experiments in such traps.
Non-Boolean hidden variable model reproduces Quantum Mechanics’ predictions for Bell’s experiment.
Authors: Hnilo Alejandro
Published: August 2022

The experimentally verified violation of Bell’s inequalities apparently implies that at least one of two beliefs, which are accepted as true in almost all scientific practice, must be false. These beliefs are: that effects propagating at infinite velocity do not exist, and that natural phenomena occur independently of being observed. Giving up any one of these two beliefs (usually known together as Local Realism) is controversial. For many years, many theories have been proposed to reconcile the violation of Bell’s inequalities with Local Realism, but none has been fully successful. In this paper, it is recalled that Bell’s inequalities are equivalent to the conditions to decide the completeness of a theory according to Boolean logic. Therefore, any theory aimed to violate Bell’s inequalities must start by giving up Boolean logic. Two problems are therefore defined: the “soft” one is to explain the violation of Bell’s inequalities without violating (non-Boolean) Local Realism; the “hard” one is to predict the time values when single particles are detected, in such a way that the resulting number of coincidences violates Bell’s inequalities. A simple hidden variables model is introduced, which solves the “soft” problem even in an ideal setup. This is possible thanks to the use of vectors in real space as the hidden variables and the corresponding operation (projection), which do not hold to Boolean logic. This model reconciles the violation of Bell’s inequalities with Local Realism and should end a controversy that has lasted for decades. Regarding the “hard” problem, the introduced model is as incomplete as Quantum Mechanics is. It is claimed that solving the “hard” problem requires devising a new kind of quantum computer, which should be able to accept (non-Boolean) hidden variable values as input data and to replace the statistical Born’s rule of Quantum Mechanics with a deterministic threshold condition.
Transcriptome Analysis of Human Peri-implant and Periodontal Gingiva: A Paired Design Study
Authors: Chen Danying , Li Zhixin , Li Zhipeng , Sun Yue , Liu Qifan , Yang Jieting , Song Jiaying , Cai Huaxiong , Chen Zhuofan , Huang Baoxin
Published: August 2022

Objectives: Limited information is available about the biological characterization of peri-implant soft tissue at the transcriptional level. The aim of this study was to investigate the effect of dental implant on the gingival tissue in vivo by using paired samples and compare the differences between peri-implant and periodontal gingiva at the transcriptional level.Methods: Paired peri-implant soft tissue and periodontal gingiva tissue from 6 patients were obtained, and the pooled RNAs were analyzed by deep sequencing. Venn diagram was used to further screen out differentially expressed genes in every pair of samples. Annotation and enrichment analysis was performed. Further verification was done by quantitative real-time PCR.Results: A total of 3549 genes including were found differently expressed between peri-implant and periodontal groups. The Venn diagram further identified 185 genes differentially expressed genes (DEGs) in every pair of samples, of which the enrichment analysis identified significant enrichment for cellular component was associated with external side of plasma membrane, for molecular function was protein binding, for biological process was immune system process, and for KEGG pathway was cytokine-cytokine receptor interaction. Among the DEGs, CST1, SPP1, AQP9 and SFRP2 were verified to be upregulated in peri-implant soft tissue.Conclusions: Peri-implant gingiva showed altered expressions of several genes related to the cell-ECM interaction.Clinical Relevance: At the transcriptional level, healthy periodontal is alternative to the healthy peri-implant soft tissue as the control of peri-implantitis to a large extent, except in the research related to cell-ECM interactions.
Evaluating the Virucidal Efficacy of Hydrogen Peroxide against SARS-CoV-2 on Different Types of Fabrics
Authors: Hassandarvish Pouya , Tiong Vunjia , Bakar Sazaly Abu , Sulaiman Wan Shahida Wan , Mohamed Nurul Azmawati , Rani Mohd Dzulkhairi Mohd , Aris Muhammad Shamsir Mohd
Published: August 2022

SARS-CoV-2 has been shown to remain infectious on surfaces from hours to days depending on the surface type and environmental factors. The presence of virus on the cloth surface may pose a risk of disease transmission during use and handling. This study aimed to investigate the virucidal effect of hydrogen peroxide against SARS-CoV-2 virus on several types of fabrics. The SARS- CoV-2 virus at a concentration similar to viral load from a throat swab of a positive COVID patient was used to test the virucidal effect of hydrogen peroxide at different concentrations and different time points on different types of fabrics using VERO E6 cell culture. This study showed that the SARS-Cov2 soaked on different types of fabrics was killed within 30 s of exposure to hydrogen peroxide. Hydrogen peroxide showed a potent virucidal effect on SARS CoV-2 on different types of fabrics.
Prognostic capability of portal vein thrombosis for rebleeding in cirrhotic patients after esophagogastric devascularization and splenectomy
Authors: Han Jianbo , Shu Qinghua , Yi Yongxiang , Sun Beicheng
Published: August 2022

Background
Esophagogastric devascularization and splenectomy (EGDS) is widely used to treat patients with portal hypertension in China. This study aimed to determine the risk factors of rebleeding after EGDS and evaluate the effect of portal vein thrombosis (PVT) on rebleeding during the postoperative period after EGDS.
Methods
Cirrhotic patients with portal hypertension who had undergone EGDS were included. The patients were assigned to either the rebleeding or the non-rebleeding group with follow-up time.
Results
A total of 138 consecutive patients who underwent EGDS and met the criteria were included in this study. The 3-year and 5-year rebleeding rates of all patients were 18.12% (25/138) and 27.54% (38/138), respectively. The total bilirubin (TBIL) (HR: 2.392, 95% CI 1.032–5.545, p = 0.042) and PVT (HR: 3.345, 95% CI 1.477–7.573, p = 0.004) were identified as the predictors of 3-year rebleeding in univariate analysis. Multivariate analysis revealed that the PVT (HR: 3.967, 95% CI 1.742–9.035, p = 0.001) was an independent factor. Hemoglobin > 87.5 g/L (HR: 3.104, 95% CI 1.283–7.510, p = 0.012) and PVT (HR: 2.349, 95% CI 1.231–4.483, p = 0.010) were the predictors of 5-year rebleeding in multivariate analysis. Albumin > 37.5 g/L was the only independent predictor of 3-year and 5-year rebleeding in patients with PVT.
Conclusions
The PVT is associated with 3-year and 5-year rebleeding in patients after EGDS but not 10-year rebleeding. Hemoglobin > 87.5 g/L is another predictor of 5-year rebleeding. High albumin levels may serve as a predictor of 3-year and 5-year rebleeding risk in patients with PVT.
A New Centrality Measure and Visualization Technique Using Multiple-Parent Nodes of Earthquakes Based on Correlation-Metric
Authors: Yamagishi Yuki , Saito Kazumi , Hirahara Kazuro , Ueda Naonori
Published: August 2022

In this paper, we address the problem of earthquake declus-tering, and propose a k-nearest neighbors approach based on the selection of multiple-parent nodes with respect to each of the given earthquakes , which can be regarded as a natural extension of the conventional correlation-metric method based on the selection of a single-parent node. Based on this approach, we develop a new centrality measure that exploits link weight assigned by a logarithmic-distance scheme and a new technique of individually visualizing each set of child nodes with respect to given target earthquakes. For experimental evaluation, we used an earthquake catalog covering Japan and selected 24 earthquakes that caused considerable damage or casualties. We first show that our proposed centrality measure using a logarithmic-distance scheme can rank these 24 major earthquakes higher than four link-weighting schemes (i.e., uniform, magnitude, inverse-distance, and normalized-inverse-distance weighting) and conventional single-parent selection. We then show that unlike the conventional approach to simultaneously visualizing all the events in the catalog, our proposed technique can produce a naturally interpretable classification result for these 24 major earthquakes, by individually visualizing each set of the first to k-th child nodes with different colored markers plotted in the directly interpretable spatio and temporal metrics. As a consequence, we confirm that our approach based on multiple-parent selection is vital and promising.
LSITA: An Integrated Framework for Leveraging Security of Internet of Things Application with Remote Patient Monitoring System
Authors: Ahmed Mohammed Imtyaz , Kannan G. , Polamuri Subba Rao
Published: August 2022

Internet of Things (IoT) applications are growing in popularity and utility leading towards more comforts and conveniences with diversified use cases. However, there are security concerns as IoT technology is made up of heterogeneous devices, protocols and standards. Therefore, the environment might have inherent security issues due to lack of an integrated security framework. Security of internet of things applications is thus crucial for the growth of such applications in the real world. Towards this end, we have proposed a series of security schemes in our prior work. In this paper, we proposed an integrated framework for Leveraging Security of Internet of Things Application (LSITA) with Remote Patient Monitoring System (RPMS) use case. The framework is named as Integrated IoT Security Framework which is realized with different schemes to have privacy and end to end security. The framework enables cloud assisted authentication, secure communications among parties involved in IoT application and an improved key sharing model for multi-user data analytics environment. Different security schemes work together with seamless integration. Remote Patient Monitoring System is the case study built to evaluate the proposed framework. Empirical results revealed that the proposed framework has holistic approach to security of IoT applications. It has potential to trigger further research in the area of IoT security.
A long-runout landslide triggered by extreme rainfall in Gokseong, South Korea on 7 August 2020
Authors: Nam Kounghoon , Wang Fawu , Dai Zili , Kim Jongtae , Choo Chang Oh , Jeong Gyo-Cheol
Published: August 2022

On 7 August 2020, a large-scale catastrophic landslide was triggered by extreme rainfall at Osan village, Gokseong County, South Jeolla Province, South Korea. The initiation mechanism of the Gokseong landslide was different from those typical landslides that occurred in South Korea. Despite the relatively low elevation and slope degree, the landslide had a long runout distance of about 640 m over a total vertical distance of 90 m. A detailed field investigation and chemical analysis were conducted to understand the possible mechanisms for the high-speed and long-runout behavior of the landslide. The terrain controlled the motion behavior of the landslide and the seepage was observed at the whole landslide body. The clay-rich soils covered on granite bedrock of the landslide deposition area from the rice paddy field to the landslide crown. The results of this study may provide basic data for further research on the mechanisms for landslide initiation and propagation.
Percutaneous fractionated radiotherapy of the groin to eliminate lymphatic fistulas after vascular surgery
Authors: Jazmati Danny , Tamaskovics Bálint , Hoff Norman , Homey Bernhard , Bölke Edwin , Boyomo Belebenie , Garabet Waseem , Haussmann Jan , Budach Wilfried , Neuwahl Judith , Schelzig Hubert , Corradini Stephanie , Griensven Martijn van , Fischer Johannes , Knoefel Wolfram Trudo , Pegani John , Pedoto Alessia , Antoch Gerald , Kirchner Julian , Lüdde Tom , Kirchner Julian , Freise Noemi , Feldt Torsten , Jensen Björn-Erik Ole , Keitel Verena , Matuschek Christian
Published: August 2022

Background: Vascular surgery of the inguinal area can be complicated by persistent lymphatic fistulas. Rapid and effective treatment is essential to prevent infection, sepsis, bleeding, and possible leg amputation. Current data on irradiation of lymphatic fistulas lacks recommendation on the appropriate individual and total dose, the time of irradiation, and the target volume. Presumably, a dose of 0.3-0.5 to 1-12 Gy should be sufficient for the purpose. Currently, radiotherapy is a “can” recommendation, with a level 4 low evidence and a grade C recommendation, according to the DEGRO S2 guidelines. As part of a pilot study, we analyzed the impact and limitations of low-dose radiation therapy in the treatment of inguinal lymphatic fistulas.Patients and Methods: As part of an internal quality control project, patients with lymphatic fistulas irradiated in the groin area after vascular surgery for arterial occlusive disease (AOD) III-IV, repair of pseudo aneurysm or lymph node dissection due to melanoma were selected, and an exploratory analysis on retrospectively collected data performed.Results: Twelve patients (10 males and 2 females) aged 62.83 + 12.14 years underwent open vascular reconstruction for stage II (n= 2), III (n=1), and IV (n=7) arterial occlusive disease (AOD), lymph node dissection for melanoma (n=1) or repair of a pseudoaneurysm (n=1). Surgical vascular access was obtained through the groin and was associated with a persistent lymphatic fistula, secreting more than 50 ml/day. Patients were irradiated five times a week up to a maximum of 10 fractions for the duration of the radiation period. Fraction of 0.4 Gy were applied in the first 7 cases, while 5 patients were treated with a de-escalating dose of 0.3 Gy. There was a resolution of the lymphatic fistula in every patient without higher grade complications.Conclusion: Low-dose irradiation of the groin is a treatment option for persistent lymphatic fistula after inguinal vascular surgery.
Geocenter motions derived from BDS observations: Effects of the solar radiation pressure model and constellation configuration
Authors: Li Xingxing , Huang Shi , Yuan Yongqiang , Zhang Keke , Lou Jiaqing
Published: August 2022

Being the first hybrid-constellation global navigation system, China’s BeiDou navigation satellite system (BDS) has been entirely constructed since July 2020 and provides open services for worldwide users. Due to the natural sensitivity of satellite tracking techniques to geocenter motion, BDS has the capability to determine the geocenter coordinates independently. This study aims to improve the precision of geocenter coordinates derived from BDS. To that end, 3-year sets of daily geocenter coordinates have been determined with BDS observations. Different solar radiation pressure models, including the empirical CODE orbit model (ECOM), the extended ECOM model (ECOM2), and the adjustable box-wing (ABW) model, have been applied for the BDS geocenter estimation. We show that the ABW model appears to mitigate the draconitic signal of BDS and reduces the amplitude of the annual signal by factors of 5.4 and 2.1 w.r.t. ECOM and ECOM2 cases. Furthermore, we studied the impact of BDS constellation configuration on the geocenter estimation. The results indicate that the inclusion of IGSO satellites significantly mitigates the spurious signals in the spectra of the geocenter coordinates, with amplitudes of the annual signal and 3-cpy signal reduced by (28%, 14%), (33%, 61%), and (65%, 45%) for ECOM, ECOM2, and ABW cases, respectively. Meanwhile, the amplitude of the 7-day signal related to the revolution period of MEO satellites is also reduced by 43–60% after the inclusion of IGSO satellites. Thus, the MEO + IGSO hybrid configuration and ABW model are recommended for BDS to determine the geocenter. The annual amplitudes of the derived geocenter coordinates are 1.3, 3.6, and 5.5 mm, compared to 3.7, 3.2, and 5.0 mm for the ILRS solution in the X, Y, and Z components, respectively. Particularly, in the Z component, the BDS constellation characteristics lead to a difference of 15 mm in the amplitude of the 3-cpy signal compared to the ILRS solution.
Algebra with ternary cyclic relations, representations and quark model
Authors: Abramov Viktor , Groote Stefan , Lätt Priit
Published: August 2022

We propose a unital associative algebra, which is motivated by a generalization of the Pauli exclusion principle proposed within the framework of the quark model. The generators of this algebra satisfy the following relations: The sum of squares of all generators is equal to zero (binary relation) and the sum of cyclic permutations of factors in any triple product of generators is equal to zero (ternary relations). We study the structure of this algebra and calculate the dimensions of spaces spanned by homogeneous monomials. It is shown how the algebra we propose is related to irreducible representations of the rotation group. Particularly we show that the 10-dimensional space spanned by triple monomials is the space of a double irreducible unitary representation of the rotation group. We use ternary q- and q- -commutators, where q,q- are primitive 3rd order roots of unity, to split the 10-dimensional space spanned by triple monomials into a direct sum of two 5-dimensional subspaces. We endow these subspaces with a Hermitian scalar product by means of an orthonormal basis of triple monomials. In each subspace there is an irreducible unitary representation so(3) -> su(5). We calculate the matrix of this representation and the structure of matrix indicates a possible connection between our algebra and the Georgi-Glashow model.
Assess ing the Influence of Geotechnical and Geomorphological Characteristics on the Erosional Processes of Two Geologic Units in Udi and Aguata, SE Nigeria
Authors: Unigwe Chinanu O. , Igwe Ogbonnaya , Onwuka Obialo S. , Egbueri Johnbosco C.
Published: August 2022

In southeastern Nigeria, gullies occurrence has seriously threatened humans and the environment. In this study, through a detailed field survey, geotechnical and geomorphological investigation, the erodibility extent of two erosion-prone geologic units in southeastern Nigeria was assessed. According to field observations, the investigated gullies were primarily composed of loose lateritic unconsolidated soils from the Ajali and Nanka geological formations. Based on the grain size study, it was discovered that the soil components for the Ajali and Nanka formations, respectively, contained gravel (0 − 3% and 5 − 22.5%), sand (7.75 − 95.0% and 66.5 − 89%), and fines (4.42 − 17.7% and 4.7 − 22.2%). The soil permeability coefficients ranged from 1.13 x 10− 5 to 2.45 x 10− 4 m/s and 6.18 x 10− 5 to 5.25 x 10− 4 m/s for the Ajali and Nanka formations, respectively. The MDD ranged from 1.69 to 1.90g/cm3 and 1.72 to 2.10g/cm3, whereas OMC ranged from 11.0 to 14.30% and 12.12 to 18.10% in the compaction test. The NMC results and the Atterberg limit indicate that the soils are non-plastic to low-plastic. The values for soil cohesion range from 0 − 6 kPa to 1 − 7 kPa. The friction angle ranges from 23 − 28o and 32 − 38o. The geomorphological characteristics revealed that the region is characterized by uneven topography and severe gully slope gradients, with the gullies within the Ajali Formation being more frequently linked with landslides. Both formations are vulnerable to erosion, according to the research. In order to combat this awful disaster, some type of mitigation strategy must be employed.