bluuebunny/crossref_metadata_2025 huggingface dataset:
Critical review of the common methods to determine the buoyancy-chimney effects in longitudinally-ventilated traffic tunnel fires
Authors: Vukoslavčević Petar V , Šekularac Milan B
Published: May 2022

Determining the buoyancy-chimney effects (hot smoke stack effects) in the case of a fire in a traffic tunnel with a slope is of key importance in the process of sizing the ventilation system and smoke control. Given the complexity of the unsteady turbulent heated flow of air and combustion products mixture and the transient heat transfer by convection, radiation and tunnel wall conduction, various approximate methods, standards, guidelines, and numerical approaches are used, giving different values for the gas temperature distribution and pressure differences. Depending on the fire heat release rate, tunnel slope, and the length of the fire-affected zone, the differences in pressure can even reach values of over 100%, strongly affecting the ventilation sizing. To evaluate the reliability of available methods, a critical review of various methods is given, and a comparison analysis carried out in the case of a typical unidirectional-traffic tunnel equipped with a longitudinal ventilation system. The temperature field, the pressure rise, and the required number of fan units, required to provide the critical velocity for smoke control, are analyzed.
Internal load distribution of single-row tapered roller bearings doubly supporting main shaft of wind turbine
Authors: Li Yunfeng , Gao Yuanan
Published: May 2022

In order to accurately understand the internal loading state of the single-row tapered roller bearings doubly supporting the main shaft of wind turbine, a 5-DOF mechanical model of such bearing combination in wind turbine was established which considered the axial preload, bearing ring tilt, and roller crown. The positions of the points on the bearing raceways were described mathematically in the Cartesian coordinate system, and the mathematical relationship between the roller-raceway contact deformations and the bearing ring displacements was derived. The effect of bearing ring tilt caused by external loads on the contact load distributions along rollers was considered by dividing the rollers into laminae. The contact stress distribution between roller and raceway was obtained by iterative calculation of the finite length line contact model. The RMSE of the roller load distributions of the upwind bearing and the downwind bearing is 2.25 kN and 3.02 kN respectively. The obtained smallest size necessary for the roller laminae is 1.25% of the roller length. The bearing ring tilt will cause uneven contact load distribution along the roller, and modification of the roller profile improves the load and stress distribution. The machining error leads to the unbalanced contact stress distribution along the roller.
Corynebacterium pyruviciproducens-peptidoglycan: A novel bacterial peptidoglycan inhibiting overexpression of MyD88 in macrophages
Authors: Wang Lin , Ma Yuan , Shi Jinfang , Zhang Yang , Tong Jia , Han Qingzhen
Published: May 2022

Objectives:

Bacterial peptidoglycan (PGN) is an essential ligand of TLR2 inducing inflammatory damage by boosting MyD88 overexpression in pathogen invasion, such as Methicillin-resistant Staphylococcus aureus (MRSA) infection. CP-PGN is a novel PGN from an adjuvant bacterium, displaying anti-infection immune regulation. This study aimed to clarify the unique moderation of MyD88 expression by CP-PGN.

Methods:

Compared with other ligands of TLR2, high expression of MyD88 in macrophages was established by MRSA and virus to investigate the immunomodulation of CP-PGN.

Results:

Compared with PGN derived from MRSA (M-PGN) and chemosynthetic Pam3CSK4 of model agonists of TLR2, CP-PGN could inhibit overexpression of MyD88 in a time- and dose-dependent way in infected macrophages by MRSA or Abelson leukemia virus. CP-PGN also promoted more anti-inflammatory IL-10 and less pro-inflammatory TNF-α in immature primary macrophages. Furthermore, IL-10 secretion induced by CP-PGN was reduced most significantly by blocking the dimer formation of MyD88 with ST2825 and lowering down expression by si-MyD88.

Conclusion:

CP-PGN could inhibit MyD88 overexpression by infection to moderate inflammatory cytokines. Therefore, CP-PGN is a novel potential ligand of TLR2 to induce inflammatory balance in the process of host defense against invading pathogens.
Distribution characteristics of ApoE gene polymorphism in the Tibetan population of Qinghai
Authors: Xie Yan-Ling , Li Jian-Xun , Ji Wei-Zhong , Yao Yong-Li
Published: May 2022

Objective:

To understand the distribution characteristics of the relative frequencies of apolipoprotein E (APOE) alleles in Tibetans of Qinghai province, to provide a basis for subsequent research.

Method:

Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the APOE genotypes and analyze the distribution characteristics in 96 indigenous Tibetans randomly selected from the Medical Examination Center of Qinghai Provincial People’s Hospital, and the results of this study were compared with those of other ethnic groups in China.

Results:

The frequencies of E2, E3, and E4 alleles in the 96 subjects were 1.563%, 89.062%, and 9.375%, respectively, and the genotype frequencies were E2/E2 (0%), E2/E3 (3.125%), E2/E4 (0%), E3/E3 (78.125%), E3/E4 (18.750%), and E4/E4 (0%), respectively. The frequency distribution of the ε2 allele in the Tibetan population was lower than that of the Northern Han, Southern Hakka, Hui, Mongolian, and Dai populations of China. The frequency distribution of the ε4 allele in the Tibetan population was of no significant difference compared with that of the Northern Han, Southern Hakka, Hui, and Mongolian populations, but was higher than that of the Dai population. The frequency distribution of the ε3 allele in the Tibetan population was of no significant difference compared with that of the Northern Han, Mongolian, and Dai populations, but higher than that of the Southern Hakka and Mongolian populations.

Conclusion:

There are ethnic differences in the frequency distribution of the three common alleles of APOE.
Linguistic adaptation and psychometric properties of the health literacy questionnaire in serbian language among people with chronic diseases
Authors: Arsenović Sladjana , Oyewole Olufemi , Trajković Goran , Osborne Richard H , Wiltshire-Fletcher Megan , Gazibara Teodora , Kisić Tepavčević Darija , Pekmezović Tatjana , Gazibara Tatjana
Published: May 2022

Objective

To translate the Health Literacy Questionnaire (HLQ) to Serbian language and examine its psychometric characteristics.

Methods

This cross-sectional study was conducted among 295 people with chronic diseases from the Foča region (Republic of Srpska, Bosnia and Herzegovina). The HLQ was translated according to the translation integrity procedure. Construct validity was tested using confirmatory factor analysis (CFA) using the maximum likelihood estimator and reliability was estimated using the α and ω coefficients.

Results

Minor linguistic differences in 17 items were observed between the original and the initial forward translation and were corrected. The parameters of one-factor CFA on domains 3 and 8 fitted well. The parameters of the CFA for domains 1, 2, 4, 5, 6, 7 and 9 were acceptable after modification using residuals’ correlation. The α and ω coefficients for all domains were good to excellent (>0.80).

Conclusion

Each domain of the HLQ in Serbian has acceptable construct validity and overall good reliability. This study adds to the growing evidence that the HLQ is a useful tool to provide in-depth multidimensional information on health literacy to improve researchers and policymakers understanding of the health literacy strengths, needs and preferences across cultures and languages.
Qualitative Insights from A Novel Staff-Led Oral Health Champions Program Within a Residential Service For People With Intellectual and Developmental Disability
Authors: Wilson Nathan J , Lin Zhen , Pithouse Margery , Morrison Bonnie , Sumar Bashir , George Ajesh
Published: May 2022

The oral health of people with intellectual and developmental disability is poorer than that of the general community. Any solution for people with intellectual and developmental disability living in residential services needs to include disability support workers (DSWs). Previous studies have used either didactic or train-the-trainer approaches to enhance DSW knowledge and skills. Taking a different approach, a novel program used DSWs as embedded oral health champions. This model provided educational opportunities for DSWs to learn about good oral health and then share with peers and provide benefits to people with intellectual and developmental disability that they support. Interviews with a sample of these champions were conducted and analysed using content analysis. Findings suggest that DSWs are capable of affecting change with the right type and depth of training, management and organisational support. A DSW-led champions model has merit, however requires ongoing expert support to help maintain and sustain benefits over time.
Are they really stronger? Comparing effects of semantic variables in speeded deadline and standard picture naming
Authors: Lampe Leonie F , Hameau Solène , Nickels Lyndsey
Published: May 2022

Investigations of effects of semantic variables on picture naming have often been inconclusive, with some studies reporting significant and others non-significant effects. One potential explanation may relate to the specific naming tasks used: While most previous studies have used standard picture naming, others have used speeded naming that requires participants to prioritise naming speed over accuracy. Speeded naming has been suggested to cause enhanced effects of item-inherent word characteristics due to disruptions of cognitive control and resulting modulations of responsiveness to input. Consequently, this study investigated whether effects are stronger in speeded compared to standard picture naming, focusing on six feature-based semantic variables: number of semantic features, intercorrelational density, number of near semantic neighbours, semantic similarity, typicality, and distinctiveness. The results showed few differences in the variables’ effects between the two naming tasks: In the naming latency analysis, the inhibitory effect of distinctiveness was stronger in the speeded naming task, while in the accuracy analysis the effect of number of semantic features was stronger in the standard naming task. These findings cannot, therefore, be exclusively accounted for by increased responsiveness to input in speeded naming and we discuss possible underlying mechanisms. We conclude that, while some differences in effects of semantic variables between previous studies may have been caused by the specific naming task used, differences between studies more likely depend on statistical power and control of other influential variables in the experiment.
The effect of proprioceptive training on technical soccer skills in female soccer
Authors: Souglis Athanasios G. , Travlos Antonios K. , Andronikos Georgios
Published: May 2022

Development of perceptual-cognitive motor skills is a crucial factor influencing soccer training and competition. The aim of the study was to examine the effects of neuromuscular coordination, proprioceptive and balance exercises on physiological attributes and technical skills in female soccer. Female soccer players competing in Greek A Division (N = 48) were assigned to intervention (N1 = 24) and control groups (N2 = 24). The Proprioceptive Training Intervention Program (PTIP) lasted approximately 20 min and was implemented five times per week for 16 weeks. It was hypothesized that the PTIP in addition to a regular training programme would significantly affect female soccer player perceptual-cognitive-motor capability as it was estimated with physiological attributes ([Formula: see text]O2max and agility) and motor performance soccer technical skills (juggling, heading, shooting, passing, and dribbling). All performance variables were measured prior and after the 16-weeks PTIP. Groups by Measures (2 × 2) ANOVAs with repeated measures on the second factor revealed that the intervention group decreased percent body fat and improved [Formula: see text]O2max and all technical skills in comparison to the control group after the PTIP ( p < 0.05). The findings demonstrate the beneficial role of a proprioceptive training programme on both physiological attributes and technical skills in female soccer. Practical implications include the application of the intervention programme for monitoring and developing soccer players while also the use of the assessment tests to evaluate players.
Investigation on fatigue life prediction and reliability design of 304 stainless steel manufactured by laser metal deposition
Authors: Huang Weibo , Zhang Yimin
Published: May 2022

Laser metal deposition (LMD) is an advanced technology to manufacture the specimen by layer-by-layer method. In this paper, the fatigue tests of 304 stainless steel (SS304) smooth specimens manufactured by LMD are conducted with the stress ratio of −1 and the frequency of 10 Hz. Considering that the fatigue crack is caused by the material defect on the subsurface, the fatigue life of smooth specimen under the different cyclic stress amplitudes are predicted based on the dislocation model, equivalent initial crack size and empirical formula. Lognormal, two-parameter Weibull and extreme maximum value distributions are applied to describe the fatigue life of the smooth specimens at the different cyclic stress amplitudes. The result shows that two-parameter Weibull distribution has the best ability to describe the fatigue life distribution. Based on two-parameter Weibull distribution, the probabilistic-stress-number ( P- S-N) curves at the four different reliability levels are plotted. Combined with the material strength degradation rule, the design checkpoint method is adopted to analyze the fatigue life reliability of smooth specimens under the different cyclic stress amplitudes. The reliability results are close to those of two-parameter Weibull distribution.
Validity and reliability of 10 Hz GPS sensor for measuring distance and maximal speed in soccer: Possible differences of unit positioning
Authors: Akyildiz Zeki , Alvurdu Sumer , Ceylan Halil Ibrahim , Clemente Filipe Manuel
Published: May 2022

In contemporary research literature, inconsistencies regarding the validity and reliability of different brands of global positioning systems (GPSs) have been reported regarding the positioning of GPS units on athletes. For this reason, the present work investigates the validity and reliability of the measurements of GPS units placed at different locations. Thirty-two amateur soccer players (age: 21.18 ± 3.16 years; height: 175 ± 8.03 cm; body mass: 74.21 ± 4.85 kg) voluntarily participated in the current study. Participants were asked to complete a team sport simulation cycle (TSSC). During the tests, two GPS units were placed between the shoulder blades and on the chest of each athlete. Data from Polar Team Pro GPS units at both locations on the body, previously measured test area distance, and a radar gun (the gold standard) were compared to determine validity. The reliability of GPS units in measuring maximum speed is moderate (CV = 9.77–9.08, ICC = 0.23). The reliability of GPS units in measuring total distance is good (CV = 4.43–9.39, ICC = 0.15). The reliability of GPS units in measuring distance covered is poor (CV = 17.51–35.37). The measurements of total distance covered, and maximum speed recorded by the chest and back GPS units are not valid (Max speed = GPS chest-radar gun; R2 = 0.075, GPS back-radar gun; R2 = 0.106, total distance = GPS chest-1200 m; R2 = 0.003, GPS back-1200 m; R2 = 0.097). Consequently, it can be said that 10-Hz Polar GPS sensors have good reliability for measuring total distance when placed on the chest and moderate reliability for measuring peak speed when placed on the chest and back; however, they have poor reliability at both positions for evaluating distances at different running speeds.
Efficacy of prolonged-release fampridine versus placebo on walking ability, dynamic and static balance, physical impact of multiple sclerosis, and quality of life: an integrated analysis of MOBILE and ENHANCE
Authors: Hupperts Raymond , Gasperini Claudio , Lycke Jan , Ziemssen Tjalf , Feys Peter , Xiao Shan , Acosta Carlos , Koster Thijs , Hobart Jeremy
Published: May 2022

Background:

MOBILE and ENHANCE were similarly designed randomized trials of walking-impaired adults with relapsing-remitting or progressive multiple sclerosis (MS) who received placebo or 10 mg prolonged-release (PR)-fampridine twice daily for 24 weeks. Both studies showed sustained and clinically meaningful improvement in broad measures of walking and balance over 24 weeks of PR-fampridine treatment.

Objective:

To evaluate the functional benefits and safety of PR-fampridine versus placebo using a post hoc integrated efficacy analysis of MOBILE and ENHANCE data.

Methods:

Data from the intention-to-treat (ITT) populations of MOBILE and ENHANCE studies were pooled in a post hoc analysis based on the following outcome measures: 12-item MS Walking Scale (MSWS-12), Timed Up and Go (TUG) speed, Berg Balance Scale (BBS), MS Impact Scale physical impact subscale (MSIS-29 PHYS), EQ-5D utility index score, visual analogue scale (VAS), and adverse events. The primary analysis was the proportion of people with MS (PwMS) with a mean improvement in MSWS-12 score (⩾8 points) from baseline over 24 weeks. A subgroup analysis based on baseline characteristics was performed.

Findings:

In the ITT population ( N = 765; PR-fampridine, n = 383; placebo, n = 382), a greater proportion of PR-fampridine–treated PwMS than placebo-treated PwMS achieved a clinically meaningful improvement in the MSWS-12 scale over 24 weeks (44.3% versus 33.0%; p < 0.001). PR-fampridine MSWS-12 responders demonstrated greater improvements from baseline in TUG speed, BBS score, MSIS-29 PHYS score, and EQ-5D utility index and VAS scores versus PR-fampridine MSWS-12 nonresponders and placebo. Subgroup analyses based on baseline characteristics showed consistency in the effects of PR-fampridine.

Conclusion:

The pooled analysis of MOBILE and ENHANCE confirms previous evidence that treatment with PR-fampridine results in clinically meaningful improvements in walking, mobility and balance, self-reported physical impact of MS, and quality of life and is effective across a broad range of PwMS.
Exploring the impact of COVID-19 movement control orders on eating habits and physical activity in low-resource urban settings in Malaysia
Authors: Lim Shiang Cheng , Kataria Ishu , Ngongo Carrie , Usek Venessa Sambai , Kudtarkar Shashank Rajkumar , Chandran Arunah , Mustapha Feisul Idzwan
Published: May 2022

Background:

The COVID-19 pandemic led Malaysia to introduce movement control orders (MCOs). While MCOs were intended to slow the spread of COVID-19, the effects of such measures on the noncommunicable disease (NCD) risk factors have not been fully explored. This exploratory study aimed to understand the effect of the MCO on the eating habits and physical activity levels of the urban poor in Malaysia as well as potential health promotion interventions during the COVID-19 pandemic.

Methods:

This rapid assessment used a mixed-method approach in three low-cost public flats in Kuala Lumpur targeting the B40, which is the bottom 40% of the economic spectrum. A total of 95 community members participated in a quantitative phone survey, while 21 respondents participated in a qualitative phone survey, including 12 community members and nine community health volunteers (CHVs).

Results:

The movement restriction imposed during the MCO significantly reduced the frequency and duration of respondents’ physical activity. At the same time, respondents reported significantly increased consumption of home-cooked meals. More than half of respondents reduced their consumption of packaged snack foods (53.7%), street desserts (54.7%), fast food (50.5%), soft drinks (50.5%), and 3-in-1 or instant drinks (50.5%) due to limited access during the MCO. B40 communities were receptive to potential interventions to encourage healthier eating and physical activity leveraging digital approaches under the ‘new normal’. Reported concerns included internet accessibility and affordability, functionality, and digital literacy.

Conclusion:

The COVID-19 pandemic requires innovation to address diseases and risk factors at the community level. While movement restrictions reduced physical activity, they created opportunities for low-income individuals to have greater control over their diet, enabling them to adopt healthier eating habits. Lifestyle changes experienced by vulnerable populations provide an opportunity for creative and technology-enabled interventions to promote healthy eating and exercise.
Provisioning behavior of male and female Loggerhead Shrikes
Authors: Ritchison Gary , Lewis Lauren , Heist C. Adam
Published: May 2022

The unique predatory, caching, and impaling behaviors of shrikes (Laniidae) may provide these unusual passerines with alternative provisioning strategies compared to other songbirds, but few studies have determined the impact these unique behaviors have on provisioning rates. Our objectives were to compare the provisioning behavior of male and female Loggerhead Shrikes ( Lanius ludovicianus), and determine how their provisioning behavior was influenced by nestling age. The provisioning behavior of six pairs of Loggerhead Shrikes was videotaped from 15 April to 15 August 2004–2007 in Garrard and Madison counties, Kentucky, USA. For each nest visit by a shrike, the sex of the visiting adult, number of prey items delivered, size of prey, type of prey, and the duration of the nest visit were recorded. Adults made 2169 visits to nests, with males (49%) and females (51%) making similar numbers of visits. Males and females differed in time spent at nests, with males spending less time at nests per visit (mean = 12.0 s, N = 1062) than females (77.0 s, N = 1107). Feeding rates did not differ between the sexes, but feeding rates did increase with nestling age. The size of prey delivered to nestlings also tended to increase with nestling age. Invertebrates comprised 65% of the identified prey items, and cached items made up the remaining 35%. Although many passerine species increase provisioning rates as nestling demand increases, the caching behavior of shrikes may allow adults to reliably increase both feeding rates and prey size as nestling age and demand increase as well as act as buffers when prey availability declines. The caching behavior of shrikes provides them with parental provisioning strategies not available to non-caching songbirds.
Ultrasound-detected inflammation is more common in clinically manifest hand osteoarthritis than in painless bony enlarged finger joints: subanalysis of the population-based Bruneck study
Authors: Gasperi Nina , Schreiber Nikolaus , Bosch Philipp , Adinolfi Antonella , Kleyer Arnd , Hagen Melanie , Gasperi Christiane , Weger Martin , Kiechl Stefan , Willeit Johann , Schett Georg , Iagnocco Annamaria , Gasperi Arno , Mayr Agnes , Dejaco Christian
Published: May 2022

Purpose:

The aim of this article is to examine the extent of structural and inflammatory lesions by ultrasound in elderly subjects with hand osteoarthritis (HOA) fulfilling the ACR classification criteria (Group A), in subjects with painless enlarged finger joints (Group B), and in individuals without clinical abnormalities at hands (Group C).

Methods:

This study was nested within the population-based, prospective Bruneck study; 293 subjects of ⩾65 years of age were assessed. Clinical and ultrasound assessment was conducted at wrists and finger joints. Gray scale synovitis (GSS), Power Doppler (PD), osteophytes, and erosions were scored semiquantitatively (0–3). The Short Form Score for the Assessment and Quantification of Chronic Rheumatic Affections of the Hands (SF-SACRAH), the Health Assessment Questionnaire (HAQ), and the Functional Index for Hand Osteoarthritis (FIHOA) were retrieved.

Results:

Most subjects had ⩾1 ultrasound abnormality, of which osteophytes were the most prevalent finding in all groups (Group A: 100%, Group B: 99.4%, and Group C: 93.9%). GSS and PD-signals were more common in Group A than in Group B (94% versus 67% and 33% versus 13%, respectively). In Group C, GSS was observed in 39.4% of subjects. In subjects with HOA, the SF-SACRAH correlated with osteophyte scores (corrcoeff = 0.48), and the FIHOA correlated with the osteophyte (corrcoeff = 0.42) and PD scores (corrcoeff = 0.33).

Conclusion:

GSS and PD were more frequent in patients with symptomatic HOA than in cases with painless bony enlargements and subjects without clinical joint abnormalities. Functional restriction in HOA is associated with structural and inflammatory ultrasound changes.
Sustainability of water and sanitation state-owned companies in Brazil
Authors: Gonçalves Edson , Werneck Capodeferro Morganna , Jerônimo Smiderle Juliana , Engel Guimarães Pedro H.
Published: May 2022

This paper assesses the sustainability of Brazilian’s water and sanitation state-owned companies’ services. The assessment was conducted based on the selection of six indicators reflecting three of the sustainability dimensions: social, economic, and environmental. We built a global sustainability index by adopting the MACBETH multicriteria analysis methodology, which aggregates the dimensions of sustainability with their respective indicators. As main result we found that two companies were considered sustainable in each of the three assessed dimensions of sustainability, and that three companies were globally sustainable according to the methodology applied in this study. Setting sustainability targets and increasing regulatory enforcement leads to improved services performance. Further, sustainable sanitation services bring us closer to achieving the national targets for universal access and Sustainable Development Goal 6 established by the United Nations.
Electronic health records post-implementation challenges in selected hospitals: A qualitative study in the Central Region of southern Ghana
Authors: Mensah Nathan K , Boadu Richard O , Adzakpah Godwin , Lasim Obed U , Amuakwa Ruth D , Taylor-Abdulai Hannah B , Chatio Samuel T
Published: May 2022

Background

Electronic health records (EHRs) are useful tools in healthcare settings but implementation in low and middle-income countries (LMIC) face challenges.

Objective

To explore post-implementation challenges affecting the deployment of EHRs and their use in selected health facilities in Ghana.

Method

Using a qualitative research approach, 21 in-depth interviews were conducted with health workers in two hospitals in the study area in Ghana, in February and June 2020. Purposive sampling was used to select participants. All interviews were audio recorded, transcribed, and coded into themes using QSR Nvivo12 software to aid thematic analyses.

Results

Post-implementation challenges were grouped into lack of technological, logistical and managerial support, and inadequate training. Inadequate equipment was the most reported post-implementation challenge that affected EHR use. Unreliable Internet and network connectivity was a source of frustration, which caused staff to develop negative attitudes towards use of the system. Lack of funding stalled implementation of the system and limited its use to critical care units only. It was also the reason replacement of equipment delayed.

Conclusion

While EHR post-implementation challenges facing health facilities are surmountable, managerial support, backed with the requisite logistical and technical support is needed. It is not enough to rely on funding; health institutions should prioritise emerging EHR post-implementation challenges in their operating budgets.

Implications

A national framework is needed to guide effective and sustainable EHR implementation across the country.
India-Kazakhstan energy relations: Looking back and looking ahead
Authors: Pradhan Ramakrushna
Published: May 2022

India and Kazakhstan share deep-rooted historical relations since millennia. The spread of Buddhism to Central Asia from India and Islam to India through Babur – the founder of the Mughal dynasty – vividly reflects at least 2500 years old cultural and civilizational ties with both the regions, yet India has been perceived in Kazakhstan as a latecomer and disinterested power. While many attribute New Delhi’s lack of political willpower and economic muscle as reasons for its consistent failure in the energy sector of Kazakhstan since 1990s, this article after thorough examination holds New Delhi’s diffident policy accountable for this. Although, at the beginning of the 21st century, the UPA government led by Dr. Manmohan Singh had tried to come out of that slumber through the initiation of ‘Connect Central Asia Policy’ yet a lack of concerted effort has derailed the renewed process. However, with Modi in New Delhi as the Prime Minister of India has shown keen interests and passionate desire to tie up with the region through commercial and strategic opportunities especially with Kazakhstan in energy sector yet both the countries need a massive overhaul in their relationship to transform the short-sighted association into a broad-based strategic engagement focussing on energy cooperation. This article uncovers the irritants, misplaced imaginations and wrong assumptions that deny India a foothold in the energy hub of Kazakhstan. It therefore argues for a paradigm shift in India’s Central Asia policy which New Delhi so far has been ignoring and strongly urges India to take Russia on board while dealing with Kazakhstan.
Natural Products Containing the Nitrile Functional Group and Their Biological Activities
Authors: Scotti Camille , Barlow James W.
Published: May 2022

The importance of nitriles as a key class of chemicals with applications across the sciences is widely appreciated. The natural world is an underappreciated source of chemically diverse nitriles. With this in mind, this review describes novel nitrile-containing molecules isolated from natural sources from 1998 to 2021, as well as a discussion of the biological activity of these compounds. This study gathers 192 molecules from varied origins across the plant, animal, and microbial worlds. Their biological activity is extremely diverse, with many potential medicinal applications.
The Reorganization of a Psychiatric Unit During COVID-19: A Reflection for Psychiatric Hospital Design
Authors: Sturge Jodi , Starrenburg Ferdi
Published: May 2022

Objective:

The COVID-19 pandemic has impacted healthcare systems worldwide. Although this disease has primarily impacted general medicine intensive care units, other areas of healthcare including psychiatry were modified in response to corona measures to decrease the transmission of the disease. Reflecting on the modifications to the environment provides an opportunity to design psychiatric environments for future pandemics or other demands for healthcare.

Background:

The therapeutic environment of psychiatric wards was modified in Friesland, the Netherlands, in response to COVID-19. During this time, an interdisciplinary team met consistently to contribute to the preliminary design of a new psychiatric hospital.

Methods:

During the first 18 months of the pandemic, clinical reflections were made to describe the impact of COVID-19 on the psychiatric care environment. Architects have created a preliminary design of a new psychiatric hospital based on these reflections, monthly collaborative design discussions based on virtual mock-ups and evidence-based design based on theoretical concepts and research.

Results and conclusions:

This theoretical and reflective study describes how an inpatient psychiatric environment was restructured to manage infection during COVID-19. The therapeutic environment of the psychiatric ward and patient care changed drastically during COVID-19. The number of patients accessing care decreased, patient autonomy was restricted, and the function of designated behavioral support spaces changed to manage the risk of infection. However, these challenging times have provided an opportunity to reflect on theories and consider the design of new hospital environments that can be adapted in response to future pandemics or be restructured for different care functions.
Risk Factors for Failure of Conservative Management of Insertional Achilles Tendinosis
Authors: Kunkle Bryce F. , Baxter Nicholas A. , Caughman Alexander M. , Barcel John A. , Scott Daniel J. , Gross Christopher E.
Published: May 2022

Introduction:

While many patients benefit from nonoperative treatment of insertional Achilles tendinopathy (IAT), some elect for surgical debridement and reconstruction. The purpose of this study is to determine the relationship of patient demographic characteristics, comorbidity profiles, and radiological parameters with failure of conservative management of IAT.

Methods:

A retrospective chart review was performed to identify patients who received either surgical or nonsurgical treatment of IAT at an academic institution from September 2015 to June 2019 (N = 226). Demographic and comorbidity data, and the presence and magnitude of relevant radiological parameters were collected and compared between the surgically (n = 48) and nonsurgically (n = 178) treated groups.

Results:

No significant differences could be detected between groups regarding demographic factors or previous procedures. The surgery group was significantly more likely to have evidence of Haglund’s deformity on clinical exam (83% vs 69%, P = .005), lower SF-12 physical scores (25.5 vs 35.5, P < .001), higher VAS pain scores (6.3 vs 5.3, P = .033), any mental illness (33% vs 20%, P = .044), and depression (27% vs 12%, P = .012).

Discussion:

Patients who received surgery for IAT were significantly more likely to have evidence of Haglund’s deformity on clinical exam, depression, higher VAS pain scores, and lower SF-12 physical scores. Both patients and surgeons should be aware of the higher rates of failure of conservative treatment in these patients.

Level of Evidence:

Level III
Impasses of Affective Inquiry in Pandemic Times
Authors: Smithers Laura E. , Fischer Heidi , Watrous Faith
Published: May 2022

This paper puzzles through the doubled impasses of our affective inquiry into learning communities in a college setting. In so doing, we take on the incommensurabilities of our field site and post qualitative inquiry, providing an example of critical qualitative inquiry where theory and practice are made to work together at their limits, both compromising with each other, neither subordinated to the other. Affective inquiry, an instantiation of concept as method inquiry, itself was a search for the impasses of learning community life. When our observations were moved to Zoom as a result of the COVID-19 pandemic, we were faced with another impasse: how to attune to affect in this new and thoroughly datafied space? We open by theorizing affective inquiry and our doubled impasse, and we then explore three locations of these impasses in our fieldwork. We close with a reaffirmation of relentless experimentation.
Exploring Value-driven Leadership: Perspectives From School Leaders
Authors: Thien Lei Mee , Adams Donnie , Kho Siaw Hui , Yap Phooi Ling
Published: May 2022

The applicability of leadership theories on leaders’ personal values in a non-Western context remains unclear. This study attempts to explore school leaders’ value-driven leadership practices in Malaysian primary schools. This study employed a qualitative approach using interviews with five school leaders from Malaysian national primary schools. Qualitative data analysis rendered a contextualization of servant-, authentic-, and ethical leadership attributes such as advocates positive discipline, tolerance to conflicts, humility and gentleness, building trust, empowerment, fairness and responsibility, joint decision-making, and rational problem solving. This study informs a better understanding of value-driven leadership practices to deal with challenging situations in schools.
Scenarios From Artificial Narrow Intelligence to Artificial General Intelligence—Reviewing the Results of the International Work/Technology 2050 Study
Authors: Kuusi Osmo , Heinonen Sirkka
Published: May 2022

This article introduces the Work/Technology 2050 study of the global Millennium Project and its main results. The article highlights how (invited) experts from different countries see the development of work and technology until 2050 and how they assess the three featured scenarios based on these views. In terms of technology, the study focused on the potential effects of artificial intelligence, while the role of basic income was given special consideration in the development prospects of work. In connection with the scenarios, the study produced hundreds of proposals for action under five different themes. Besides presenting and evaluating these scenarios and proposals for action, the Finnish authors of the article provide their own reflections and some critical remarks.
Extracellular Vesicles from Hypoxic Pretreated Urine-Derived Stem Cells Enhance the Proliferation and Migration of Chondrocytes by Delivering miR-26a-5p
Authors: Wan Sha , Bao Dingsu , Li Jia , Lin Kefu , Huang Qi , Li Qiang , Li Lang
Published: May 2022

Objective

Stem-cell therapy is a promising treatment for cartilage defects. The newly identified urine-derived stem cells (USCs), which have multipotency and sufficient proliferative ability, are promising candidates for several tissue engineering therapies. In this study, we investigated the role of USC extracellular vehicles (EVs) in promoting the proliferation and migration of chondrocytes.

Design

USCs were characterized by measuring induced multipotent differentiation and flow cytometry analysis of surface marker expression. The EVs were isolated from USCs under normoxic conditions (nor-EVs) and hypoxic conditions (hypo-EVs). Transmission electron microscopy and western blot analysis characterized the EVs. The chondrocytes were cultured in the USC-EVs. CCK-8 assay and EdU staining detected the proliferation of chondrocytes, and transwell assay detected their migration. miR-26a-5p expression in EVs was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The target relationship of miR-26a-5p and phosphatase and tensin homolog (PTEN) was predicted and confirmed. The roles of EVs-miR-26a-5p and PTEN on the proliferation and migration of chondrocytes were also investigated.

Results

Hypo-EVs showed a superior effect in promoting the proliferation and migration of chondrocytes than nor-EVs. Mechanistically, USC-EVs delivered miR-26a-5p into chondrocytes to overexpress miR-26a-5p. PTEN was identified as an miR-26a-5p target in chondrocytes. The effects of EVs-miR-26a-5p on promoting the proliferation and migration of chondrocytes were mediated by its regulation of PTEN.

Conclusion

Our study suggested that hypoxic USC-EVs may represent a promising strategy for osteoarthritis by promoting the proliferation and migration of chondrocytes via miR-26a-5p transfer.
The Current Status of Clinical Trials on Biologics for Cartilage Repair and Osteoarthritis Treatment: An Analysis of ClinicalTrials.gov Data
Authors: Zhang Zijun , Schon Lew
Published: May 2022

Objective

Biologics are increasingly used for cartilage repair and osteoarthritis (OA) treatment. This study aimed to provide an overview of the clinical trials conducted on this subject.

Design

Two-word combinations of two sets of key words “cartilage”; “joint”; “osteoarthritis” and “biologics”; “stem cells”; “cell implantation” were used to search the database of ClinicalTrials.gov and supplemented with searches of PubMed and EMbase. The registered trials were analyzed for clinical conditions, completion status, phases, and investigated biologics. Recently completed trials with posted/published results were summarized.

Results

From 2000 to 2022, a total of 365 clinical trials were registered at ClinicalTrials.gov to use biologics for cartilage repair and OA treatment. Since 2006, the number of registered trials accelerated at an annual rate of 16.4%. Of the 265 trials designated with a phase, 72% were early Phase 1, Phase 1, and Phase 2. Chondrocytes and platelet-rich plasma (PRP) were studied in nearly equal number of early- and late-stage trials. Mesenchymal stem/stromal cells (MSCs) were the most commonly investigated biologics (38%) and mostly derived from bone marrow and adipose tissue (70%). In last 5 years, 32 of the 72 completed trials posted/published results, among which seven Phase 3 trials investigated chondrocytes, PRP, bone marrow aspirate concentrate, hyaluronic acid, collagen membrane, and albumin.

Conclusions

There was a rapid increase in the number of registered clinical trials in recent years, using a variety of biologics for cartilage repair and OA treatment. Majority of the biologics still require late-stage trials to validate their clinical effectiveness.
The Role of Interleukin-4 and Interleukin-10 in Osteoarthritic Joint Disease: A Systematic Narrative Review
Authors: van Helvoort E.M. , van der Heijden E. , van Roon J.A.G. , Eijkelkamp N. , Mastbergen S.C.
Published: May 2022

Objective

A fusion protein of interleukin-4 and interleukin-10 (IL4-10 FP) was developed as a disease-modifying osteoarthritis drug (DMOAD), and chondroprotection, anti-inflammation, and analgesia have been suggested. To better understand the mechanisms behind its potential as DMOAD, this systematic narrative review aims to assess the potential of IL-4, IL-10 and the combination of IL-4 and IL-10 for the treatment of osteoarthritis. It describes the chondroprotective, anti-inflammatory, and analgesic effects of IL-4, IL-10, and IL4-10 FP.

Design

PubMed and Embase were searched for publications that were published from 1990 until May 21, 2021 (moment of search). Key search terms were: Osteoarthritis, Interleukin-4, and Interleukin-10. This yielded 2,479 hits, of which 43 were included in this review.

Results

IL-4 and IL-10 showed mainly protective effects on osteoarthritic cartilage in vitro and in vivo, as did IL4-10 FP. Both cytokines showed anti-inflammatory effects, but also proinflammatory effects. Only in vitro IL4-10 FP showed purely anti-inflammatory effects, indicating that proinflammatory effects of one cytokine can be counteracted by the other when given as a combination. Only a few studies investigated the analgesic effects of IL-4, IL-10 or IL4-10 FP. In vitro, IL-4 and IL4-10 FP were able to decrease pain mediators. In vivo, IL-4, IL-10, and IL4-10 FP were able to reduce pain.

Conclusions

In conclusion, this review describes overlapping, but also different modes of action for the DMOAD effects of IL-4 and IL-10, giving an explanation for the synergistic effects found when applied as combination, as is the case for IL4-10 FP.
Global Variation in Studies of Articular Cartilage Procedures of the Knee: A Systematic Review
Authors: Steinmetz R. Garrett , Guth J. Jared , Matava Matthew J. , Smith Matthew V. , Brophy Robert H.
Published: May 2022

Objective

The objective of this study was to determine whether there are significant differences in terms of indications, techniques, patient variables, and objective and subjective outcome scores as a function of the geographic locale of published studies of knee articular cartilage surgery.

Methods

An electronic database search was performed of clinical studies evaluating knee articular cartilage procedures from 2000 to 2021. Studies were separated into global regions (Europe, Asia, North America, and South America) based on the study country. All cartilage-based treatments in each region were recorded. Patient age and sex, mechanism of injury, cartilage lesion size and location, follow-up time, failure rate, and knee outcome scores utilized were summarized and compared by region.

Results

A total of 2,923 studies were analyzed. Eighty level 1 and 2 studies met the inclusion criteria. The majority were from Europe ( n = 60), followed by Asia ( n = 11), North America ( n = 7), and South America ( n = 2). The majority of procedures in European and North American studies were cell-based and marrow-stimulation procedures. In Asian studies, the most common procedures were marrow-stimulation, experimental, and biologic procedures as defined by the authors. Asian countries had a higher proportion of females ( P < 0.001) and an overall older patient population ( P < 0.001). Regional variation was also seen in terms of lesion location, mechanism of injury, and failure rate.

Conclusion

Most high-level evidence for articular cartilage-based procedures of the knee comes from European countries. These studies vary by patient age and sex, anatomic location, and mechanism of injury. Global variation should be taken into consideration when interpreting and applying studies of knee articular cartilage surgery.
Predicting Academic Performance with an Assessment of Students’ Knowledge of the Benefits of High-Level and Low-Level Construal
Authors: Nguyen Tina , Scholer Abigail A. , Miele David B. , Edwards Michael C. , Fujita Kentaro
Published: May 2022

Metamotivation research suggests that people understand the benefits of engaging in high-level versus low-level construal (i.e., orienting toward the abstract, essential versus concrete, idiosyncratic features of events) in goal-directed behavior. The current research examines the psychometric properties of one assessment of this knowledge and tests whether it predicts consequential outcomes (academic performance). Exploratory and confirmatory factor analyses revealed a two-factor structure, whereby knowledge of the benefits of high-level construal (i.e., high-level knowledge) and low-level construal (i.e., low-level knowledge) were distinct constructs. Participants on average evidenced beliefs about the normative benefits of high-level and low-level knowledge that accord with published research. Critically, individual differences in high-level and low-level knowledge independently predicted grades, controlling for traditional correlates of grades. These findings suggest metamotivational knowledge may be a key antecedent to goal success and lead to novel diagnostic assessments and interventions.
Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis complicated with macrophage activation syndrome
Authors: Ding Yukang , Ge Yongpeng
Published: May 2022

Background:

Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive dermatomyositis (DM) has low survival rate, whereas macrophage activation syndrome (MAS) is a severe and life-threatening syndrome associated with autoimmune diseases. Their coexistence is very rare. This study aimed to describe the prevalence, clinical characteristics, and outcomes of anti-MDA5 antibodies-positive DM patients complicated with MAS.

Methods:

In this retrospective study, we enrolled DM patients with anti-MDA5 antibodies, who were hospitalized between 2016 and 2020 and included patients diagnosed with MAS.

Results:

We identified four (2%) DM patients with anti-MDA5 antibodies. They were females with interstitial lung disease (ILD). The level of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and ferritin were significantly higher in the MAS group than those without MAS ( p < 0.05). Patients with MAS were significantly more likely to develop a dysphagia ( p = 0.012). Literature review revealed eight similar cases. Together with the present study, we identified 12 patients complicated with ILD. The median age of disease onset was 52 years with a male to female ratio of 1:6. The median duration between DM onset and MAS diagnosis was 3 months. The mortality of MAS in anti-MDA5 antibody-positive DM was 50%. Patients who died were older than those who survived (56.7 years versus 35.5 years; p = 0.015).

Conclusions:

MAS was rare in anti-MDA5 antibody-positive DM. The higher the level of AST, LDH, and ferritin, the greater the risk of MAS. They were associated with high mortality rates, particularly in older patients.