bluuebunny/crossref_metadata_2025 huggingface dataset:
Holistic Sensitivity Analysis for Long-Term Energy Demand Prediction of Battery Electric Vehicles
Authors: Schäfers Lukas , Iravanimanesh Sahba , Franke Kai , Savelsberg Rene , Pischinger Stefan
Published: October 2024

Accurate and robust range estimation algorithms for battery electric vehicles have the potential to reduce range anxiety, increase the acceptance of lower-range vehicles, and improve the overall driving experience. However, developing such algorithms faces challenges due to the complexity of the driver-vehicle-environment system and the multitude of factors influencing a vehicle's energy demand. To address these challenges, this paper introduces a sensitivity analysis focused on driver- and environment-related factors, which are notably difficult to predict. Employing a global sensitivity analysis for factor prioritization, this study delineates and assesses the parameters and their value distributions using a validated vehicle simulation model. The co-simulation of a powertrain and an auxiliaries model enables the parameter-specific investigation of parameters related to the thermal system. The results are scenario-individual parameter rankings that show the importance of the considered factors in prediction algorithms and guide the strategy for the development of these algorithms. The acceleration behavior of the driver, often emphasized in literature, is shown to be of secondary importance to energy consumption. Moreover, factors such as air density and wind speed are identified as crucial in highway driving scenarios, whereas outside temperature and the probability of stopping at traffic lights are critical in urban settings. For validation purposes, the resulting rankings of the sensitivity study are validated by means of a convergence analysis.
The uniqueness of unconditional basis of the 2-convexified Tsirelson space, revisited
Authors: Albiac Fernando , Ansorena José L.
Published: October 2024

One of the hallmarks in the study of the classification of Banach spaces with a unique (normalized) unconditional basis was the unexpected result by Bourgain, Casazza, Lindenstrauss, and Tzafriri from their 1985 Memoir that the 2-convexified Tsirelson space $${\mathcal {T}}^{(2)}$$

T

(
2
)

had that property (up to equivalence and permutation). Indeed, on one hand, finding a “pathological” space (i.e., not built out as a direct sum of the only three classical sequence spaces with a unique unconditional basis) shattered the hopeful optimism of attaining a satisfactory description of all Banach spaces which enjoy that important structural feature. On the other hand it encouraged furthering a research topic that had received relatively little attention until then. After forty years, the advances on the subject have shed light onto the underlying patterns shared by those spaces with a unique unconditional bases belonging to the same class, which has led to reproving the original theorems with fewer technicalities. Our motivation in this note is to revisit the aforementioned result on the uniqueness of unconditional basis of $${\mathcal {T}}^{(2)}$$

T

(
2
)

from the current state-of-art of the subject and to fill in some details that we missed from the original proof.
Rapid Geomagnetic Variations During High‐Speed Stream, Sheath and Magnetic Cloud‐Driven Geomagnetic Storms From 1996 to 2023
Authors: Pedersen M. N. , Juusola L. , Vanhamäki H. , Aikio A. T. , Viljanen A.
Published: October 2024

The most detrimental geomagnetically induced currents (GICs) documented to date have all taken place during geomagnetic storms. Yet, the probability of GICs throughout geomagnetic storms driven by different solar wind transients, such as high‐speed streams/stream interaction regions (HSS/SIR) or interplanetary coronal mass ejection (ICME) sheaths and magnetic clouds (MC), is poorly understood. We present an algorithm to detect geomagnetic storms and storm phases, resulting in a catalog of 755 geomagnetic storms from January 1996 to June 2023 with the solar wind drivers. Using these storms and the IMAGE magnetometer network, we study the temporal and spatial evolution of spikes in the time derivative of the horizontal component of the external magnetic field, , greater than 0.5 nT/s during geomagnetic storms driven by HSS/SIR, sheaths and MCs. Spikes occur more often toward the end of the storm main phase for HSS/SIR and MC‐driven storms, while sheaths have spikes throughout the entire main phase. During the main phase most spikes occur in the morning sector around 05 magnetic local time (MLT) and the extent in MLT is narrowest for MCs and widest for sheaths. However, spikes in the pre‐midnight sector during the main and recovery phases are most prominent for HSS/SIR‐driven storms. During the storm sudden commencement (SSC), three MLT hotspots exist, the post‐midnight at 04 MLT, pre‐noon at 09 MLT and afternoon at 15 MLT. The pre‐noon hotspot has the highest probability of spikes and the widest extent in magnetic latitude.
Polyploidy mitigates the impact of DNA damage while simultaneously bearing its burden
Authors: Hayashi Kazuki , Horisaka Kisara , Harada Yoshiyuki , Ogawa Yuta , Yamashita Takako , Kitano Taku , Wakita Masahiro , Fukusumi Takahito , Inohara Hidenori , Hara Eiji , Matsumoto Tomonori
Published: October 2024

Polyploidy is frequently enhanced under pathological conditions, such as tissue injury and cancer in humans. Polyploidization is critically involved in cancer evolution, including cancer initiation and the acquisition of drug resistance. However, the effect of polyploidy on cell fate remains unclear. In this study, we explored the effects of polyploidization on cellular responses to DNA damage and cell cycle progression. Through various comparisons based on ploidy stratifications of cultured cells, we found that polyploidization and the accumulation of genomic DNA damage mutually induce each other, resulting in polyploid cells consistently containing more genomic DNA damage than diploid cells under both physiological and stress conditions. Notably, despite substantial DNA damage, polyploid cells demonstrated a higher tolerance to its impact, exhibiting delayed cell cycle arrest and reduced secretion of inflammatory cytokines associated with DNA damage-induced senescence. Consistently, in mice with ploidy tracing, hepatocytes with high ploidy appeared to potentially persist in the damaged liver, while being susceptible to DNA damage. Polyploidy acts as a reservoir of genomic damage by mitigating the impact of DNA damage, while simultaneously enhancing its accumulation.
Too big to purge: persistence of deleterious Mutations in Island populations of the European Barn Owl (Tyto alba)
Authors: Lavanchy Eléonore , Cumer Tristan , Topaloudis Alexandros , Ducrest Anne-Lyse , Simon Céline , Roulin Alexandre , Goudet Jérôme
Published: October 2024

A key aspect of assessing the risk of extinction/extirpation for a particular wild species or population is the status of inbreeding, but the origin of inbreeding and the current mutational load are also two crucial factors to consider when determining survival probability of a population. In this study, we used samples from 502 barn owls from continental and island populations across Europe, with the aim of quantifying and comparing the level of inbreeding between populations with differing demographic histories. In addition to comparing inbreeding status, we determined whether inbreeding is due to non-random mating or high co-ancestry within the population. We show that islands have higher levels of inbreeding than continental populations, and that this is mainly due to small effective population sizes rather than recent consanguineous mating. We assess the probability that a region is autozygous along the genome and show that this probability decreased as the number of genes present in that region increased. Finally, we looked for evidence of reduced selection efficiency and purging in island populations. Among island populations, we found an increase in numbers of both neutral and deleterious minor alleles, possibly as a result of drift and decreased selection efficiency but we found no evidence of purging.
UV photochemistry of the L-cystine disulfide bridge in aqueous solution investigated by femtosecond X-ray absorption spectroscopy
Authors: Ochmann Miguel , Harich Jessica , Ma Rory , Freibert Antonia , Kim Yujin , Gopannagari Madhusudana , Hong Da Hye , Nam Daewoong , Kim Sangsoo , Kim Minseok , Eom Intae , Lee Jae Hyuk , Yorke Briony A. , Kim Tae Kyu , Huse Nils
Published: October 2024

The photolysis of disulfide bonds is implicated in denaturation of proteins exposed to ultraviolet light. Despite this biological relevance in stabilizing the structure of many proteins, the mechanisms of disulfide photolysis are still contested after decades of research. Herein, we report new insight into the photochemistry of L-cystine in aqueous solution by femtosecond X-ray absorption spectroscopy at the sulfur K-edge. We observe homolytic bond cleavage upon ultraviolet irradiation and the formation of thiyl radicals as the single primary photoproduct. Ultrafast thiyl decay due to geminate recombination proceeds at a quantum yield of >80 % within 20 ps. These dynamics coincide with the emergence of a secondary product, attributed to the generation of perthiyl radicals. From these findings, we suggest a mechanism of perthiyl radical generation from a vibrationally excited parent molecule that asymmetrically fragments along a carbon-sulfur bond. Our results point toward a dynamic photostability of the disulfide bridge in condensed-phase.
Unsupervised deep denoising for four-dimensional scanning transmission electron microscopy
Authors: Sadri Alireza , Petersen Timothy C. , Terzoudis-Lumsden Emmanuel W. C. , Esser Bryan D. , Etheridge Joanne , Findlay Scott D.
Published: October 2024

By simultaneously achieving high spatial and angular sampling resolution, four dimensional scanning transmission electron microscopy (4D STEM) is enabling analysis techniques that provide great insight into the atomic structure of materials. Applying these techniques to scientifically and technologically significant beam-sensitive materials remains challenging because the low doses needed to minimise beam damage lead to noisy data. We demonstrate an unsupervised deep learning model that leverages the continuity and coupling between the probe position and the electron scattering distribution to denoise 4D STEM data. By restricting the network complexity it can learn the geometric flow present but not the noise. Through experimental and simulated case studies, we demonstrate that denoising as a preprocessing step enables 4D STEM analysis techniques to succeed at lower doses, broadening the range of materials that can be studied using these powerful structure characterization techniques.
Why scanning tunneling spectroscopy of Sr2RuO4 sometimes doesn’t see the superconducting gap
Authors: Valadkhani Adrian , Profe Jonas B. , Kreisel Andreas , Hirschfeld P. J. , Valentí Roser
Published: October 2024

Scanning tunneling spectroscopy (STS) and scanning tunneling microscopy (STM) are perhaps the most promising ways to detect the superconducting gap size and structure in the canonical unconventional superconductor Sr2RuO4 directly. However, in many cases, researchers have reported being unable to detect the gap at all in STM conductance measurements. Recently, an investigation of this issue on various local topographic structures on a Sr-terminated surface found that superconducting spectra appeared only in the region of small nanoscale canyons, corresponding to the removal of one RuO surface layer. Here, we analyze the electronic structure of various possible surface structures using first principles methods, and argue that bulk conditions favorable for superconductivity can be achieved when removal of the RuO layer suppresses the RuO4 octahedral rotation locally. We further propose alternative terminations to the most frequently reported Sr termination where superconductivity surfaces should be observed.
Aerosol immunization with influenza matrix, nucleoprotein, or both prevents lung disease in pig
Authors: Vatzia Eleni , Paudyal Basudev , Dema Barbara , Carr Brigid Veronica , Sedaghat-Rostami Ehsan , Gubbins Simon , Sharma Bhawna , Moorhouse Elliot , Morris Susan , Ulaszewska Marta , MacLoughlin Ronan , Salguero Francisco J. , Gilbert Sarah C. , Tchilian Elma
Published: October 2024

Current influenza vaccines are strain-specific and require frequent updates to combat new strains, making a broadly protective influenza vaccine (BPIV) highly desirable. A promising strategy is to induce T-cell responses against internal proteins conserved across influenza strains. In this study, pH1N1 pre-exposed pigs were immunized by aerosol using viral vectored vaccines (ChAdOx2 and MVA) expressing matrix (M1) and nucleoprotein (NP). Following H3N2 challenge, all immunizations (M1, NP or NPM1) reduced lung pathology, but M1 alone offered the greatest protection. NP or NPM1 immunization induced both T-cell and antibody responses. M1 immunization generated no detectable antibodies but elicited M1-specific T-cell responses, suggesting T cell-mediated protection. Additionally, a single aerosol immunization with the ChAdOx vaccine encoding M1, NP and neuraminidase reduced lung pathology. These findings provide insights into BPIV development using a relevant large natural host, the pig.
Sustainable detergent-disinfectant agent based on whey mineralizate and silver nanoparticles for cleaner production in dairy industry
Authors: Blinov Andrey , Blinova Anastasiya , Nagdalian Andrey , Siddiqui Shahida Anusha , Gvozdenko Alexey , Golik Alexey , Rekhman Zafar , Filippov Dionis , Shariati Mohammad Ali , AL-Farga Ammar , Al-maaqar Saleh M.
Published: October 2024

Detergents and disinfectants for dairy industry must meet a variety of characteristics, including low toxicity, high antibacterial activity, and excellent rinsing of pollutants from working surfaces. This work presents an innovative detergent-disinfectant agent based on whey mineralizate and silver nanoparticles (Ag NPs), which allows reducing production costs and ensuring high cleanliness of treated surfaces compared to analogues. For this purpose, a method for obtaining sols of Ag NPs stabilized with didecyldimethylammonium bromide (Ag NPs-DDAB) was developed and optimized using neural network algorithms. Characterization of Ag NPs-DDAB showed particles with a radius of 4.5 nm and 20 nm, stable in the pH range from 2 to 11. An acute toxicity study of Ag NPs in mice showed LD50 = 4230 μg/kg. Based on the degree of accumulation and inhalation toxicity, Ag NPs-DDAB are classified as low-hazard chemicals. The developed detergent-disinfectant had a washability of about 90%, high antimicrobial activity (0.005 mg/mL) against Penicillium roqueforti and a sanitary and hygienic effect on coliforms, general contamination and pathogenic microorganisms, a low-corrosive effect and low toxicity (315 mg/mL) to Danio rerio. It was concluded that the use of detergent-disinfectant agent will completely eliminate the consumption of water for the equipment cleaning process and can be used to clean an electrodialysis unit’s circuits, enabling the utilization of secondary waste from membrane milk processing and promoting resource efficiency and cleaner production in the dairy industry.
Identifying risk factors for recurrent multidrug resistant tuberculosis based on patient’s record data from 2016 to 2021: retrospective study
Authors: Wotale Teramaj Wongel , Lelisho Mesfin Esayas , Negasa Bikiltu Wakuma , Tareke Seid Ali , Gobena Woldemariam Erkalo , Amesa Ebsa Gelan
Published: October 2024

Globally, the prevalence of multidrug-resistant tuberculosis (MDR-TB) has been increasing recently. This is a major public health concern, as MDR-TB is more difficult to treat and has poorer outcomes compared to drug-sensitive tuberculosis. The main objective of the study was to identify risk factors for recurrent multidrug-resistant tuberculosis, at Alert Specialized Hospital, Addis Ababa, by using different parametric shared frailty models. From January 2016 to December 2021, a retrospective study was conducted on MDR-TB patients at Alert Specialized Hospital in Addis Ababa. The data for the study were collected from the medical records of MDR-TB patients at the hospital during this time period. Gamma and inverse-Gaussian shared frailty models were used to analyze the dataset, with the exponential, Weibull, and lognormal distributions included as baseline hazard functions. The data were analyzed using R statistical software. The median recurrence time of the patients was 12 months, and 149 (34.3%) had recurrences. The clustering effect was statistically significant for multiple drug-resistant tuberculosis patients’ recurrence. According to the Weibull-Inverse-Gaussian model, factors that reduced time to MDR-TB recurrence included lower weight (ɸ = 0.944), smoking (ɸ = 0.045), alcohol use (ɸ = 0.631), hemoptysis (ɸ = 0.041), pneumonia (ɸ = 0.564), previous anti-TB treatment (ɸ = 0.106), rural residence (ɸ = 0.163), and chronic diseases like diabetes (ɸ = 0.442) were associated with faster recurrence. While, higher education (ɸ = 3.525) and age (ɸ = 1.021) extended time to recurrence. For weight increment, smokers and alcohol users, clinical complications of hemoptysis and pneumonia, patients with pulmonary disease who had a history of previous anti-TB treatment, and being rural residents are prognostic factors. There was a significant clustering effect at the Alert Specialized Hospital in Addis Ababa, Ethiopia. The Weibull-Inverse Gaussian Shared Frailty Model was chosen as the best model for predicting the time to recurrence of MDR-TB.
Effect of three different root canal sealants on human dental pulp stem cells
Authors: Alfahlawy Ahmad , Selim Manar A. A. , Hassan Hayam Y.
Published: October 2024

The cytotoxic effects of three root canal sealers with different bases on human dental pulp stem cells were assessed in this study using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test. The cytotoxic effects of three root canal sealers with different bases on human dental pulp stem cells (DPSCs) were assessed in this study using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test. The cytotoxicity of the sealers was tested after one, 4, and 7 d. Human dental pulp stem cell proliferation was concluded using an MTT assay. Cells not treated with sealer extract were used as controls. The absorption levels were measured using an Eliza spectrophotometer. P was set at 0.05 when the percentage of cell proliferation was matched between groups and observation times using one-way analysis of variance (ANOVA).During the second passage (P2), human dental pulp stem cells displayed a single morphological and phenotypic trait, with fibroblast morphology being the most common. There were no appreciable variations between the four groups after a day. There was a notable variation in the average percentage of cell proliferation between the groups after 4 and 7 days. The control group had the highest percentage, followed by the GuttaFlow Bioseal group, the Well Root St group, and the AH-Plus group, which had the lowest percentage. For every sealing group, after one day, the highest mean percentage of cell proliferation was recorded, followed by day four, and after day seven, the lowest mean percentage. The observation periods showed minimal cytotoxic effects of GuttaFlow Bioseal, whereas AH-Plus was the most cytotoxic to human dental pulp stem cells. The highest mean percentage of cell proliferation for all sealers was recorded on day one.
Novel eco-friendly HPTLC method using dual-wavelength detection for simultaneous quantification of duloxetine and tadalafil with greenness evaluation and application in human plasma
Authors: Derayea Sayed M. , Zaafan Al Amir S. , Nagy Dalia M. , Oraby Mohamed , Amir Al , Zaafan S.
Published: October 2024

A novel, environmentally friendly, and sensitive HPTLC method has been developed and validated for simultaneous quantification of duloxetine (DLX) and tadalafil (TDL) in their pure state, laboratory-prepared mixtures, and spiked human plasma. This method is particularly important for patients dealing with depression and sexual issues, as it allows for the measurement of these co-administered antidepressant and sexual stimulant drugs in biological fluids. The separation process employed a stationary phase of pre-coated silica gel 60 F254 and a mobile phase consisting of ethyl acetate, acetonitrile, and 33% ammonia (8:1:1, v/v). The optimized mobile phase resulted in well-defined bands for DLX and TDL, with Rf values of 0.3 and 0.8, respectively with dual-wavelength detection at 232 nm for DLX and 222 nm for TDL. Polynomial regression analysis revealed exceptional linearity for both drugs, with correlation coefficients of 0.9999 over concentration ranges of 10–900 ng/band for DLX and 10-1200 ng/band for TDL. The quantitation limits were 8.2 ng/band for DLX and 8.6 ng/band for TDL, while the detection limits (LOD) were 2.7 ng/band for DLX and 2.8 ng/band for TDL. The validation of this method followed the guidelines set by the International Council for Harmonization (ICH). Additionally, the suggested method’s greenness was assessed by means of four up-to-date ecological tools, namely the Eco-Scale, the National Environmental Method Index (NEMI), the Green Analytical Procedure Index (GAPI), and the Analytical Greenness metric approach (AGREE). The proposed method was also assessed using the Blue Applicability Grade Index (BAGI), a recently developed metric for assessing the practicality (blueness) of procedures.
Differential regulation of expression of the protein kinases DYRK1A and DYRK1B in cancer cells
Authors: Vorwerk Vincent Andreas , Wilms Gerrit , Babendreyer Aaron , Becker Walter
Published: October 2024

The protein kinases DYRK1A and DYRK1B are pivotal regulators of cell cycle progression by promoting cell cycle exit into quiescence. DYRK1B appears to play a more important role in cancer cell quiescence than DYRK1A, as evidenced by its overexpression or copy number variations in human tumour samples. Nonetheless, the stimuli driving DYRK1B upregulation and the potential divergence in expression patterns between DYRK1A and DYRK1B remain largely elusive. In the present study, we scrutinized the regulatory pathways modulating DYRK1B expression relative to DYRK1A in PANC-1 and A549 cancer cell lines across varying conditions. Serum deprivation, pharmacological mTOR inhibition and increased cell density resulted in the differential upregulation of DYRK1B compared to DYRK1A. We then aimed to assess the role of protein kinases MST1 and MST2, which are key transmitters of cell density dependent effects. Unexpectedly, exposure to the MST1/2 inhibitor XMU-MP-1 resulted in increased DYRK1B levels in A549 cells. Further investigation into the off-target effects of XMU-MP-1 unveiled the inhibition of Aurora kinases (AURKA and AURKB) as a potential causative factor. Consistently, AURK inhibitors VX-680 (tozasertib), MLN8237 (alisertib), AZD1152-HQPA (barasertib) resulted in the upregulation of DYRK1B expression in A549 cells. In summary, our findings indicate that the expression of DYRK1A and DYRK1B is differentially regulated in cancer cells and reveal that the kinase inhibitor XMU-MP-1 increases DYRK1B expression likely through off target inhibition of Aurora kinases.
Sub-THz and THz Cherenkov radiation source with two-dimensional periodic surface lattice and multistage depressed collector
Authors: MacLachlan Amy J. , Zhang Liang , Konoplev Ivan V. , Phelps Alan D. R. , Robertson Craig W. , MacInnes Philip , Whyte Colin G. , Ronald Kevin , Cross Adrian W. , Henderson Mark A.
Published: October 2024

We present the theory, concept and design of an efficient, megawatt coherent Cherenkov radiation source based on a two-dimensional periodic surface lattice (2D-PSL) cavity combined with a novel energy recovery system for the generation of highly efficient (> 50%) single-frequency radiation. We demonstrate the scalability of the transverse dimension of the 2D-PSL cavity of the Cherenkov source and thus the potential for efficient, continuous-wave, high-power (> 1 MW) operation; fundamental to the eventual realization of clean, fusion energy. These new sources, with the capacity to operate in the 0.1-10THz range, hold strong promise to address the long-standing “Terahertz gap”. By combining a Cherenkov oscillator driven by a non-gyrating beam with an innovative four-stage depressed collector energy recovery system, the overall device efficiency can be increased to be competitive with gyrotrons in the requirements for heating and current drive in fusion plasma. In these Cherenkov devices, the frequency independence of the magnetic guide field enables advantageous frequency scaling without deployment constraints, making them especially attractive for high-impact applications in fusion science, turbulence diagnostics, non-destructive testing and biochemical spectroscopy. The novel energy recovery techniques presented in this paper have broad applicability to many electron-beam driven devices, bringing revolutionary potential to future THz source technologies.
Latin American adults who regularly use macrodoses of psychedelics: a cross-sectional study
Authors: Véliz-García Oscar , Domic-Siede Marcos
Published: October 2024

Psychedelics have a complex history marked by traditional use among indigenous cultures, early scientific interest, and subsequent prohibition. Despite their classification as controlled substances, recent decades have witnessed a resurgence of research into their therapeutic potential for various mental health conditions. However, most studies have focused on controlled clinical settings, leaving a significant gap in understanding how these substances are used in naturalistic contexts, particularly in Latin America. This study investigates the regular use of macrodoses of psychedelics among Latin American adults. We aimed to characterize the sociodemographic profiles, consumption practices, and subjective effects experienced by individuals who use psychedelics regularly. Data were collected via an online survey from 4,270 participants across several Latin American countries. Results indicated a diverse user base with varied motivations, predominantly psychological and spiritual well-being. The most frequently used substance was psilocybin mushrooms, with significant associations found between demographic variables and specific psychedelics used. The study provides new insights into the naturalistic use of psychedelics in Latin America, highlighting the need for informed, safe, and legal use frameworks.
Assessment of a LPG hybrid solar dryer assisted with smart air circulation system for drying basil leaves
Authors: Khater El-Sayed Gomaa , Bahnasawy Adel Hamed , Oraiath Awad Ali Tayoush , Alhag Sadeq K. , Al-Shuraym Laila A. , Moustapha Moustapha Eid , Elwakeel Abdallah Elshawadfy , Elbeltagi Ahmed , Salem Ali , Metwally Khaled A. , Abdalla Mohamed A. I. , Hussein Mahmoud M. , Abdeen Mohamed Anwer
Published: October 2024

The fluctuation of solar radiation throughout the day presents a significant obstacle to the widespread adoption of solar dryers for the dehydration of agricultural products, particularly those that are sensitive to high temperatures, such as basil leaf drying during the winter season. Consequently, this recent study sought to address the limitations of solar-powered dryers by implementing a hybrid drying system that harnesses both solar energy and liquid petroleum gas (LPG). Furthermore, an innovative automatic electronic unit was integrated to facilitate the circulation of air between the drying chamber and the ambient environment. Considering the solar radiation status in Egypt, an LPG hybrid solar dryer has been developed to be suitable for both sunny and cloudy weather conditions. This hybrid solar dryer (HSD) uses indirect forced convection and a controlled auxiliary heating system (LPG) to regulate both temperature and relative humidity, resulting in increased drying rates, reduced energy consumption, and the production of high-quality dried products. The HSD was tested and evaluated for drying basil leaves at three different temperatures of50, 55, and 60 °C and three air changing rates of 70, 80, and 90%, during both summer and winter sessions. The obtained results showed that drying basil at a temperature of 60 °C and an air changing rate of 90% led to a decrease in the drying time by about 35.71% and 35.56% in summer and winter, respectively, where summer drying took 135–210 min and winter drying took 145–225 min to reach equilibrium moisture content (MC). Additionally, the effective moisture diffusivity ranged from 5.25 to 9.06 × 10− 9 m2/s, where higher values of effective moisture diffusivity (EMD) were increased with increasing both drying temperatures and air change rates. Furthermore, the activation energy decreased from 16.557 to 25.182 kJ/mol to 1.945–15.366 kJ/mol for the winter and summer sessions, respectively. On the other hand, the analysis of thin-layer kinetic showed that the Modified Midilli II model has a higher coefficient of determination R2, the lowest χ2, and the lowest root mean square error (RMSE) compared to the other models of both winter and summer sessions. Finally, the LPG hybrid solar dryer can be used for drying a wide range of agricultural products, and it is more efficient for drying medicinal plants. This innovative dryer utilizes a combination of LPG and solar energy, making it efficient and environmentally friendly.
Validation and comparison of virtual reality and 3D mobile games for cognitive assessment against ACE-III in 82 young participants
Authors: Bhargava Yesoda , Kottapalli Ashwani , Baths Veeky
Published: October 2024

Current medical and clinical ecosystem for dementia detection is inadequate for its early detection. Traditional cognitive assessments are introduced after cognitive impairment has begun to disrupt the real-world functioning of the person. Moreover, these tools are paper-pen based and fail to replicate the real-world situations wherein the person ultimately lives, acts and grows. The lack of tools for early detection of dementia, combined with absence of reliable pharmacological cure compound the problems associated with dementia diagnosis and care. Advancement of technology has facilitated early prediction of disease like cancer, diabetes, heart disease, but hardly any such translation has been observed for dementia or cognitive impairment. Given this background, we examine the potential of Virtual Reality (VR) and 3D Mobile-based goal-oriented games for cognitive assessment. We evaluate three games (2 in VR, one in mobile) among 82 young participants (aged 18–28 years) and compare and contrast the game-based results with their Addenbrooke Cognitive Examination (ACE-III) scores. Three main analysis methods are used: Correlative, Z-score and Regression analysis. Positive correlation was observed for ACE-III and game-based scores. Z-scores analysis revealed no difference between the two scores, and stronger statistical significance was found between game scores and cognitive health factors like age, smoking compared to ACE-III. Specific game performances also revealed about real-world traits of participants, like hand-use confusion and direction confusion. Results establish the plausibility of using goal-oriented games for more granular, time-based, and functional cognitive assessment.
Metabolomic changes in preterminal serum samples of rhesus macaques exposed to two different lethal doses of total-body gamma-radiation
Authors: Carpenter Alana D. , Empfield Keirstyn M. , Petrus Sarah A. , Fatanmi Oluseyi O. , Wise Stephen Y. , Tyburski John B. , Cheema Amrita K. , Singh Vijay K.
Published: October 2024

Exposure to ionizing radiation induces cellular and molecular damage leading to a cascade of events resulting in tissue and organ injury. Our study strives to characterize and validate metabolomic changes in preterminal stage (immediately prior to death) samples collected from rhesus macaques lethally irradiated with one of two different doses of radiation. Peripheral blood samples were collected pre-exposure, post-exposure, and at the preterminal stage of nonhuman primates (NHPs that did not survive exposure with 7.2 Gy or 7.6 Gy total-body radiation (LD60-80/60)). We analyzed global metabolomic alterations using ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight mass spectrometry (QTOF-MS) in serum samples collected at various timepoints in relation to radiation exposure. The goal of this study was to validate the metabolic shifts present in samples collected just prior to death, which were reported earlier in a preliminary study with a limited number of samples and a single dose of radiation. Here, we demonstrate that radiation exposure induced significant time-dependent metabolic alterations compared with pre-exposure samples. We observed significant metabolite dysregulation in animals exposed to 7.6 Gy compared to 7.2 Gy. Greater metabolic disruption was observed in the preterminal groups than all of the other post-irradiation timepoints in both cohorts. Metabolomic shifts in these preterminal groups also revealed consistent disturbances in sphingolipid metabolism, steroid hormone biosynthesis, and glycerophospholipid metabolism pathways. Overall, the sphingolipid metabolism pathway appears to be representative of the preterminal phenotype, confirming the results of our preliminary study. These results offer important and novel insights for identification and validation of biomarkers for lethality, and such observations would be valuable for triage during a radiological/nuclear mass casualty scenario.
Validity of GPS data in driving cycles
Authors: Smith Harry , Akhtar Suhail , Caulfield Brian , O'Mahony Margaret
Published: October 2024

There is continuous research into driving cycles (DCs) as researchers across the globe seek to define driving characteristics, energy consumption, and emissions in a local context. For decades, data collection for the development of DCs has been conducted in three ways: chase car, instrumented vehicle, or a combination of both. Many studies have moved on to cheap and easily available global positioning system (GPS) technology, while others record vehicle data directly through the on‐board diagnostics (OBD) port. However, there are major limitations to GPS data collection such as frequent inaccuracies and loss of coverage in urban environments. For this reason, both OBD and GPS vehicle speed data have been collected. Then, the recorded data has been analysed to capture any differences in sampling rates and dropping data. Finally, basic DCs were created from smoothed GPS and OBD data and compared. DCs were developed with a microtrip‐based method, and a relative error term was used to compare candidate DCs to the collected data. DCs were compared based on kinematic characteristic parameters that are most used in the field. The results of this study could be used to assess the validity of GPS‐based DCs compared to OBD cycles using low‐cost devices.
Green synthesis of cerium oxide nanoparticles via Linum usitatissimum seeds extract and assessment of its biological effects
Authors: Foroutan Zahra , Sabouri Zahra , Afshari Amir Reza , Mostafapour Asma , Far Bahareh Farasati , Jalili‐Nik Mohammad , Darroudi Majid
Published: October 2024

In the current work, CeO2‐NPs were produced via a green chemistry process via Linum usitatissimum seeds extract as the stabilizing agent. The CeO2‐NPs were characterized by the results of analytical techniques such as TGA/DTA, FTIR, UV–vis, XPS, XRD, and FESEM/PSA/EDX. The outcomes of the XRD pattern affirmed the crystalline structure of this product with the suggested size of about 20 nm, while the FESEM/PSA pictures presented spherical morphology. Additionally, the XPS analysis of CeO2‐NPs affirmed the presence of a Ce+3 oxidation state in the sample, as well as Ce+4 as the major valence of cerium oxide. The results of the MTT test on Huh‐7 cancer cells and HFF normal cells displayed the lack of any significant cytotoxicity even at concentrations up to 1000 µg/mL. Therefore, the obtained synthesized CeO2‐NPs through this green method could be suggested as a prospective agent for medical applications due to its non‐toxic effects.
A non‐isolated single‐input dual‐output DC–DC boost converter with high‐voltage gain
Authors: Abbasi Saeed , Nahavandi Ali
Published: October 2024

This paper presents a new structure of a high step‐up DC–DC converter. The proposed converter has one input and two outputs with different voltage levels, suitable for applications that require multiple voltage levels such as photovoltaic systems, electric vehicles and DC microgrids. The proposed converter is expandable to more outputs and has a higher voltage conversion ratio compared to similar converters. The operational modes of the proposed converter are investigated and the conversion ratio of the converter is obtained. Additionally, small‐signal equations of the converter are derived, and using state‐space matrices, transfer functions of the converter are obtained and the controller is designed. Also, the proposed converter is compared with similar converters and power losses equations of the converter are derived. To investigate the converter's performance, simulations are done using MATLAB/Simulink software. Moreover, to validate the theoretical analysis, a laboratory prototype is implemented. The obtained results confirm the operation of the proposed converter.
Active protection scheme based on high‐frequency current for distribution networks with inverter‐interfaced distributed generators
Authors: Li Haifeng , Liang Huamin , Wang Zhidong , Zhang Zhenggang , Liang Yuansheng
Published: October 2024

With the high penetration and flexible access of inverter‐interfaced distributed generators (IIDGs), it is gradually becoming difficult for traditional protection schemes to meet the requirements for the safe operation of distribution networks (DNs). Active protection schemes based on power electronic equipment provide a new approach. On the basis of the controllability of voltage source converters, a method for active high‐frequency signal injection and a selection principle for the corresponding control parameters are proposed. Considering the impact of T‐connected load branches on the protected line, the high‐frequency current characteristics at the three terminals during internal and external faults are analysed. On this basis, an active protection scheme based on high‐frequency current is proposed for DNs with IIDGs. The performance of the proposed scheme is verified via PSCAD/EMTDC simulation software. The test results show that the proposed scheme can reliably trip during internal faults and identify faulty phases, which has better endurance to fault resistance.
Power allocation optimization strategy for multiple virtual power plants with diversified distributed flexibility resources
Authors: Qiu Zejian , Zhang Xin , Han Zhanyuan , Chen Fengchao , Luo Yuxin , Zhang Kuan
Published: October 2024

The virtual power plant integrating the flexible resources in the distribution network can provide additional adjustment capacity for the auxiliary services of distribution network. However, the actual internal situation of distribution network including insufficient adjustable capacity of energy storage, unreasonable power allocation, and voltage overrun leads to the difficulties in optimization scheduling. Therefore, this paper proposes a power allocation optimization strategy of distributed electricity‐H2 virtual power plants (EHVPPs) with aggregated flexible resources. Specifically, a distributed EHVPP division method based on the granular K‐medoids clustering algorithm is proposed to realize the independent autonomy and coordinated interaction between EHVPPs, and in order to quantify the operation and regulation capacity of distributed EHVPPs, an aggregation approach of regulating feasible domains of flexibility resources based on the improved zonotope approximations is developed. Moreover, a power allocation strategy based on the flexibility weight factor is proposed to handle the calculated minimum deviation between the total active output of PV and the dispatching power command, realizing the self‐consistency of distributed EHVPPs. Comparative studies have demonstrated the superior performance of the proposed methodology in economic merits and self‐consistency efficiency.
Severe and unclassifiable tremor
Authors: Serrano-Dueñas Marcos
Published: October 2024

Background Patients often exhibit very severe or disabling forms of tremor that cannot be clearly characterized.

Objective To present a series of 37 cases of tremor considered unclassifiable. Patients diagnosed with essential tremor according to criteria of the International Parkinson Disease and Movement Disorder Society (IPDMDS), who had been previously studied, were included as controls. All patients underwent a battery of tests between 2019 and 2022, which enabled us to compare them.

Methods Relevant demographic and clinical information were collected. The following tools were applied: the Mini-Mental State Examination (MMSE); the Hospital Anxiety and Depression Scale (HADS); the Fahn-Tolosa-Marín Tremor Rating Scale (TRS); and the Quality of Life in Essential Tremor (QUEST). A simple brain magnetic resonance imaging (MRI) scan was performed for all patients. The categorical variables were compared using the Chi-squared test and the t-test with Fisher correction if appropriate, and the quantitative variables were compared through the two-tailed Student t-test. Values of p ≤ 0.01 were considered statistically significant.

Results The cases presented higher scores on the anxiety and depression subscales of the HADS than the controls (p ≤ 0.006 and 0.000 respectively). In all domains of the TRS, the cases scored significantly higher, as well as in the QUEST. History of enolism was higher among the controls, and history of orthostasis and rest tremor was higher among the cases (p ≤ 0.000). Cerebellar atrophy was present in every patient in the case group, and in 24 subjects in the control group. Dystonia was observed in 7 subjects in the case group, and in none of the patients in the control group.

Conclusion There are patients with unclassifiable and extremely disabling tremors who respond poorly to the pharmacological therapy options.
Why should a 5q spinal muscular atrophy neonatal screening program be started?
Authors: Becker Michele Michelin , Nardes Flávia , Dangouloff Tamara , Servais Laurent , Araujo Alexandra Prufer de Queiroz Campos , Gurgel-Giannetti Juliana
Published: October 2024

Spinal muscular atrophy (SMA) is a genetic neuromuscular progressive disorder that is currently treatable. The sooner the disease-modifying therapies are started, the better the prognosis. Newborn screening for SMA, which is already performed in many countries, has been scheduled to begin in the near future. The development of a well-organized program is paramount to achieve favorable outcomes for the child who is born with the disease and for the costs involved in health care. We herein present a review paper hoping to point out that SMA neonatal screening is urgent and will not increase the cost of its care.
Leading innovation in transdisciplinary care
Authors: Chadwick Martin , Hemler Jennifer R. , Crabtree Benjamin F.
Published: October 2024

Background Benefits of effective team-based working in healthcare settings are well established, with the ultimate form being transdisciplinary teams. Achieving transdisciplinary teams at the large organisation or system level has not been extensively studied. Purpose To examine and describe exemplar organisations where transdisciplinary working was enabled and that can be reproduced in other organisations. Methods An expert panel reached consensus on three healthcare organisations in the USA that exemplified transdisciplinary working. Available public information about each organisation was reviewed and site visits with direct observation and interviews were conducted with two of the three exemplar sites (the third completed remotely due to the onset of COVID-19). The process of immersion-crystallisation was used to review the collated material and to identify key themes that were then repeatedly checked with the expert panel. Results Consistent themes were identified across all three organisations, although they each arrived at these commonalities via distinctly different routes. All had a clear and shared creation story as to how they came about as an entity, which was supported by consistent longitudinal leadership. This enabled an environment whereby each organisation created its own language that reflected their culture as an organisation, thus continually reinforcing the uniqueness of their organisation. Conclusions Large healthcare organisations can achieve the concepts of transdisciplinary practice. While no single achievement pathway was identified, common themes noted were a clear creation story, consistent leadership, and building a language that reflected the organisation.
The Living Well, Living Longer program: an integrated care strategy to improve the health of people living with severe mental illness
Authors: Simpson Andrew , Parcsi Lisa , McDonald Andrew
Published: October 2024

Living Well, Living Longer (The Program) is an integrated care strategy to improve the physical health of people living with severe mental illness within a public mental health service. The significant life expectancy gap experienced by this cohort is largely attributed to higher rates of cardiovascular disease and modifiable risk factors. The Program addresses this by guiding people through the four stages of screening, detection, treatment initiation, and ongoing management of coexisting chronic health conditions. The Program adopted an integrated care approach to ensure the provision of appropriate and coordinated care across hospital and primary care services. Key care pathways include a cardiometabolic health assessment clinic, shared care with general practitioners, oral health services partnership and employment of peer support workers, dietitians, exercise physiologists, and smoking cessation to provide targeted community support and interventions. There has been strong engagement with the care pathways introduced since The Program’s inception in 2013 and evaluation is currently underway to consider the impact on cardiometabolic health outcomes for participants. Critical to The Program’s effectiveness has been engagement with lived experience expertise, multidisciplinary collaboration, and strong executive support. However, significant challenges persist amid an Australian public health crisis characterised by reducing rates of free primary healthcare access for people living with severe mental illness and enduring communication challenges between primary and secondary health services. With the implementation of MyMedicare and the imminent Single Digital Patient Record across NSW Health, we stand at a critical juncture. It is imperative to establish robust systems to enhance care for this vulnerable population.