bluuebunny/crossref_metadata_2025 huggingface dataset:
IL-18 and IL-18 binding protein are related to severity of myelodysplastic syndromes
Authors: Wang Ting , Ran NingYuan , Li Nianbin , Zang Mengtong , He Xin , Chen Qiulin , Fu Rong , Shao Zonghong
Published: September 2022

Background Myelodysplastic syndromes (MDS) was defined as a clonal hematopoietic disorder disease. Although current stratified therapy for MDS has greatly improved overall survival, there is still a subset of them who suffered from progression to AML with a poor prognosis. Immune factors play essential roles in the pathogenesis and evolution of MDS. It is known that the level of plasma IL-18 which has anti-tumor and immunomodulatory effects increased in MDS patients. Recent research found that the presence of IL-18 binding protein(IL-18BP) depresses its effect. In this study, we intended to discuss the importance of IL-18 and IL-18BP on the severity of MDS and the potential mechanisms affecting the efficacy and explore new targets for MDS further therapy. Methods 43 MDS patients, 14 AML patients, and 16 healthy volunteers were enrolled in our study. The levels of IL-18, IL-18BP of bone marrow supernatant were tested by ELISA and clinical information was collected. The expression of perforin, granzyme B, and IFN-γ, as well as PD-1 and TIM-3 expression on the surface CD8 + T and NK cells, was tested in MDS patients by flow cytometry, and correlations among all these data were analyzed by SPSS. Results We found that the levels of IL-18, IL-18BP, and free IL-18 (fIL-18) in the bone marrow supernatants of both MDS and AML were higher than those of healthy controls. FIL-18 were negatively correlated with the severity of MDS. CD8 + T cells in MDS were hypofunctional, with a lower secretion of perforin, granzyme B, and IFN-γ than in healthy controls. The level of fIL-18 was positively correlated with perforin and IFN-γ; the expression of IL-18Rα on the surface of CD8 + T cells was low in MDS patients. The expression of IL-18Rα was negatively correlated with perforin, granzyme B, and IFN-γ. In addition, elevated levels of PD-1 and TIM-3 on the surface of CD8 + T cells in MDS seemed no significant correlation with fIL-18 and IL-18BP. Conclusion MDS is in a state of immunosuppression as evidenced by the decreased number and depressed function of CD8 + T cells and NK cells. Increased expression of fIL-18 in MDS patients was shown, compared to healthy controls. Due to the presence of IL-18BP, fIL-18 is relatively insufficient. Thus antagonizing IL-18BP is a promising new target for MDS.
The structure, stability, thermochemistry, and bonding in SO3-(H2O)n (n=1–7) clusters: a computational analysis
Authors: Ambigapathy Suvitha , Sathiyamoorthy Venkataramanan Natarajan , Sahara Royoji
Published: September 2022

The structure, stability, and intermolecular interactions in SO3-(H2O)n(n = 1 -7) clusters were investigated using density functional and wave functional methods. The putative global minimum shows the SO3molecule tends to be on the surface water clusters. The increase in the number of water molecules chalcogen bond distance between water molecules and SO3decreases, while the maximum number of water molecules coordinated to the SO3molecule remains at three. The calculated solvation energy increases with the increase in the number of water molecules and it does not saturate, which indicates that the addition of water molecules can add up to the existing water cluster network. The interaction energy between water molecules and SO3was less than the solvation energy conforming to the cluster forming of water molecules. The Gibbs free energy and entropy values decrease with the increase in cluster size, signifying the amount of water molecule decide the sequential hydration process. Thermochemistry data at various temperatures show that low-temperature regions found in the upper part of the troposphere favor hydration formation. Molecular electrostatic potentials (MESP) show reduced Vs,max value of π-hole on sulfur atom, and increased value on hydrogens of water molecules which results in the addition of water which leads to the sequential addition of water molecules to the water network. The quantum theory of atoms in molecules (QTAIM) shows the presence of S···O, O···H interactions between SO3and water molecules. Between water molecules O···H, H-bonding interactions were observed, and in larger clusters, O···O interaction was also noticed. QTAIM analysis shows the water–water HBs in these clusters are weak H-bond, while the SO3-water interaction can be classified as medium H-bonds which was further supported by the NCI and 2D RDG plots.
Application of β-triketone herbicides improves the purity of two-line hybrid rice seed without compromising yield
Authors: Zhang Xiuli , Wang Qing , Fan Guojian , Lou Jianhang , Li Xiaoxiu , Tang Li , Shao Ye , Mao Bigang , Lv Qiming , Zhao Bingran
Published: September 2022

Two-line hybrid rice based on Photoperiod/thermo-sensitive genic male sterile (P/TGMS) lines has been developed and applied widely in agriculture due to the freedom in making hybrid combinations, less difficulty in breeding sterile lines, and simpler procedures for breeding and producing hybrid seed. However, there are certain risks associated with hybrid seed production; if the temperature during the P/TGMS fertility-sensitive period is lower than the critical temperature, seed production will fail due to self-pollination. In a previous study, we found that the issue of insufficient purity of two-line hybrid rice seed could be initially addressed by using the difference in tolerance to β-triketone herbicides (bTHs) between the female parent and the hybrid seeds. In this study, we further investigated the types of applicable herbicides, application methods, application time, and the effects on physiological and biochemical indexes and yield in rice. The results showed that this method could be used for hybrid purification by soaking seeds and spraying plants with the bTH benzobicylon (BBC) at safe concentrations in the range of 37.5-112.5 mg/L, and the seeds could be soaked in BBC at a treatment rate of 75.0 mg/L for 36–55 h without significant negative effects. The safe concentration for spraying in the field is 50.0-400.0 mg/L BBC at the three-leaf stage. The two methods of hybrid seed purification can reach 100% efficiency without compromising the nutritional growth and yield of hybrid rice. Unlike BBC, Mesotrione (MST) can only be sprayed to achieve hybrid purification at concentrations between 10.0 and 70.0 mg/L without affecting yield. bTH stress significantly increases the index of the reactive oxygen species (ROS) hydrogen peroxide (H2O2) in the hybrid LLY942 in the safe concentration range. The peroxidase (POD) enzyme activity showed a significant upward trend with increasing herbicide concentration, which kept the content of the lipid peroxide malondialdehyde (MDA) within a certain range that did not affect the normal growth of the rice hybrids. Our study establishes a foundation for the application of the bTH seed purification strategy and showed that it is the most economical, convenient, and effective way to improve the purity of two-line hybrid rice seeds.
Bronchiectasis in renal transplant patients: A cross-sectional study Authorship
Authors: Mulette Pauline , Perotin Jeanne-Marie , Muggeo Anaëlle , Guillard Thomas , Brisebarre Audrey , Meyer Hélène , Hagenburg Jean , Ancel Julien , Dormoy Valérian , Vuiblet Vincent , Launois Claire , Lebargy François , Deslee Gaëtan , Dury Sandra
Published: September 2022

Background: Bronchiectasis is a chronic airway disease characterized by permanent and irreversible abnormal dilatation of bronchi. Several studies have reported the development of bronchiectasis after renal transplantation (RT), but no prospective study specifically assessed bronchiectasis in this population. This study aimed to compare features of patients with bronchiectasis associated with RT to those with idiopathic bronchiectasis.
Methods: Nineteen patients with bronchiectasis associated with RT (RT-B group) and 23 patients with idiopathic bronchiectasis (IB group) were prospectively included in this monocentric cross-sectional study. All patients underwent clinical, functional, laboratory and CT-scan assessments. Sputum was collected from 25 patients (n = 11 with RT-B and n = 14 with IB) and airway microbiota was analysed using an extended microbiological culture.
Results: Dyspnea (>2 on mMRC scale), number of exacerbations, pulmonary function tests, total bronchiectasis score, severity and prognosis scores (FACED and E-FACED), and quality of life scores (SGRQ and MOS SF-36) were similar in the RT-B and IB groups. By contrast, chronic cough was less frequent in the RT-B group than in the IB group (68% vs96%, p = 0.03). The prevalence and diversity of the airway microbiota in sputum was similar in the two groups.
Conclusion: Clinical, functional, thoracic CT-scan and microbiological characteristics of bronchiectasis are overall similar in patients with IB and RT-B. These results highlight that in RT patients, chronic respiratory symptoms and/or airway infections should lead to consider the diagnosis of bronchiectasis. Further studies are required to better characterize the pathophysiology of RT-B including airway microbiota, its incidence and impact on therapeutic management.
A case of multicystic biliary hamartoma with a marked peribiliary gland component successfully treated by purely laparoscopic anatomical liver resection
Authors: Kai Keita , Ide Takao , Tanaka Tomokazu , Kido Shinichi , Yukimoto Kumpei , Irie Hiroyuki , Noshiro Hirokazu , Aishima Shinichi
Published: September 2022

Background
Multicystic biliary hamartoma (MCBH) is an extremely rare benign liver lesion characterized by a gross well-circumscribed multicystic honeycomb appearance. This report presents a MCBH case with a marked peribiliary gland component which showed unusual histology.
Case presentation:
A 63-year-old Japanese male was admitted to our hospital for a detailed examination of a hepatic cystic lesion, which was originally detected 14 years ago and had slowly enlarged. A preoperative imaging study revealed a well-demarcated multicystic lesion without communication to the biliary tracts. The possible clinical diagnoses were mucinous cystic neoplasm (MCN) or MCBH. The lesion was successfully resected by purely laparoscopic right anterior sectionectomy considering the malignant potential of the lesion and hepatic functional reserve of the patient. The cut surfaces of resected specimens grossly exhibited a well-circumscribed multicystic lesion with a thick septum. Histologically, the cyst wall was covered by cuboidal epithelial cells resembling epithelium of the bile duct while abundant small ducts, which morphologically resembled peribiliary glands, were observed among the fibrous stroma of the thick septum. Although possible pathological diagnosis varied, including intrahepatic cholangiocarcinoma, intraductal papillary neoplasm of the bile duct, biliary adenofibroma, MCN and MCBH, the lesion was finally diagnosed as MCBH with a marked peribiliary gland component.
Conclusions
MCBH can contain abundant peribiliary glands in the fibrous stroma. A pathologist should be careful not to diagnose such peribiliary glands in MCBH as neoplastic glands.
Feature Analysis for Machine Learning-based IoT Intrusion Detection
Authors: Sarhan Mohanad , Layeghy Siamak , Portmann Marius
Published: September 2022

Internet of Things (IoT) networks have become an increasingly attractive target of cyberat-tacks. Powerful Machine Learning (ML) models have recently been adopted in the implementation of network intrusion detection systems to protect IoT networks. For the successful training of such ML models, selecting the right data features is crucial, maximising the detection accuracy and computational efficiency. This paper comprehensively analyses the importance and predictive power of feature sets for the detection of network attacks. Three feature selection algorithms: chi-square, information gain and correlation, have been utilised to identify and rank data features. The attributes are fed into two ML classifiers: deep feed-forward and random forest, to measure their attack detection performance. The experimental evaluation considered three datasets: UNSW-NB15, CSE-CIC-IDS2018, and ToN-IoT in their proprietary flow format. In addition, the respective variants in NetFlow format were also considered, i.e., NF-UNSW-NB15, NF-CSE-CIC-IDS2018, and NF-ToN-IoT. The experimental evaluation explored the marginal benefit of adding individual features. Our results show that the accuracy initially increases rapidly with adding features but converges quickly to the maximum. This demonstrates a significant potential to reduce the computational and storage cost of intrusion detection systems while maintaining near-optimal detection accuracy. This has particular relevance in IoT systems, with typically limited computational and storage resources.
Discrete late Jurassic Sn mineralizing events in the Xianghualing Ore District, South China: Constraints from cassiterite and garnet U-Pb geochronology
Authors: Wang Kexin , Zhai Degao , Williams-Jones Anthony E. , Li Dengfeng , Liu Jiajun
Published: September 2022

Numerous skarn-type Sn deposits have been identified in the Nanling Range (South China), of which the Shizhuyuan W-Sn-Bi-Mo, Xianghualing Sn, Jinchuantang Sn-Bi, and Hehuaping Sn deposits are the largest. The Xianghualing deposit, which is the focus of this study, hosts a resource of 0.17 Mt Sn grading 0.93–1.39 wt% SnO2. Whether the distal skarn-type mineralization and the cassiteritesulfide vein-type orebody in the Xianghualing district are genetically related to the Laiziling granitic pluton, which produced the proximal skarn-type Sn mineralization, however, is still unknown. The Xianghualing Sn mineralization occurs exclusively as cassiterite and has been subdivided into four ore-types: (1) lenticular proximal skarn ore (Cst I) containing the mineral assemblage cassiteritepyrrhotite-chalcopyrite-actinolite-wollastonite; (2) layered distal skarn ore (Cst II) containing the mineral assemblage cassiterite-pyrrhotite-chalcopyrite-actinolite; (3) vein cassiterite-sulfide ore (Cst III) distal from the skarn and associated granite containing the mineral assemblage cassiterite-arsenopyrite-pyrrhotite-muscovite-fluorite; and (4) veinlet Sn-Pb-Zn ore (Cst IV) distal from the skarn and associated granite containing the mineral assemblage cassiterite-galena-sphalerite-topaz-quartz. Here, we report the results of in situ laser ablation inductively coupled plasma mass spectrometric (LA-ICPMS) U-Pb age determinations for garnet from the Xianghualing skarn and the above four types of cassiterite. Our age determinations indicate that there were two independent magmatic-hydrothermal events at ~160 and 156~150 Ma, both of which led to Sn mineralization. The first Sn mineralization event at ~160 Ma (Cst IV U-Pb ages of 159.6 ± 1.4 to 158.5 ± 0.8 Ma) is interpreted to have been associated with a speculative unexposed granitic pluton, which is coeval with the nearby Jianfengling granite intrusion. The second Sn mineralization event at 156~150 Ma (Cst I to Cst III U-Pb ages of 155.9 ± 0.7 to 152.3 ± 1.1 Ma and garnet U-Pb ages of 153.6 ± 7.6 to 151.5 ± 3.5 Ma) is genetically related to the adjacent Laiziling granitic intrusion (152.8 ± 1.2 Ma, zircon U-Pb age). This event was responsible for the bulk of the Sn resource (>95%). Our age determinations provide convincing evidence for superimposed Jurassic Sn mineralizing systems at Xianghualing. They also show the value of combining garnet and cassiterite U-Pb age determinations to constrain the timing of skarn and Sn mineralization and distinguish discrete Sn mineralizing events in a protracted metallogenic history.
Ryabchikovite, CuMg(Si2O6), a new pyroxene group mineral, and some genetic features of natural anhydrous copper silicates
Authors: Shchipalkina Nadezhda V. , Vereshchagin Oleg S. , Pekov Igor V. , Belakovskiy Dmitry I. , Koshlyakova Natalia N. , Shilovskikh Vladimir V. , Pankin Dmitriy V. , Britvin Sergey N. , Sandalov Fedor D. , Sidorov Evgeny G.
Published: September 2022

Ryabchikovite, ideally CuMg(Si2O6), a new pyroxene-group mineral (IMA No. 2021-011) was discovered in exhalations of the active Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. The associated minerals are diopside, hematite, cuprospinel, fluorophlogopite, anhydrite, johillerite, tilasite, and aphthitalite-group sulfates. Ryabchikovite forms thin (up to 25 μm), light brown to reddish-brown epitactic crusts on short-prismatic brownish-gray crystals of diopside (up to 0.5 mm). The new mineral is optically biaxial (+), α = 1.685(5), β = 1.690(5), γ = 1.703(4), and 2V (meas) = 60(15)°. The average chemical composition (wt%, electron microprobe data) is: MgO 18.05, CaO 0.77, CuO 26.46, ZnO 2.23, Al2O3 0.93, Fe2O3 1.89, SiO2 50.10, total 100.43. The empirical formula calculated based on 6 O atoms per formulas unit is (Mg1.05Cu0.78Zn0.06Fe0.063+Ca0.03)(Si1.96Al0.04O6). Electron backscattered diffraction and powder X-ray diffraction show that ryabchikovite is a Cu,Mg-ordered analog of clinoenstatite. Ryabchikovite adopts the space group P21/с and has the following unit-cell parameters: a = 9.731(9), b = 8.929(8), c = 5.221(4) Å, β = 110.00(6)°, V = 426.3(7) Å3, and Z = 4. Ryabchikovite is named in honor of the outstanding Russian geochemist and petrologist Igor Dmitrievich Ryabchikov (1937–2017). Our studies reveal that copper analogs of rock-forming minerals could be found in fumarolic systems. Their crystallization does not require high temperatures or/and pressures (below 500 °C/Pa).
Self-stabilized Bose polarons
Authors: Schmidt Richard , Enss Tilman
Published: September 2022

The mobile impurity in a Bose-Einstein condensate (BEC) is a
paradigmatic many-body problem. For weak interaction between the
impurity and the BEC, the impurity deforms the BEC only slightly and
it is well described within the Fröhlich model and the Bogoliubov
approximation. For strong local attraction this standard approach,
however, fails to balance the local attraction with the weak
repulsion between the BEC particles and predicts an instability
where an infinite number of bosons is attracted toward the impurity.
Here we present a solution of the Bose polaron problem beyond the
Bogoliubov approximation which includes the local repulsion
between bosons and thereby stabilizes the Bose polaron even near and
beyond the scattering resonance. We show that the Bose polaron
energy remains bounded from below across the resonance and the size
of the polaron dressing cloud stays finite. Our results demonstrate
how the dressing cloud replaces the attractive impurity potential
with an effective many-body potential that excludes binding. We
find that at resonance, including the effects of boson repulsion,
the polaron energy depends universally on the effective
range. Moreover, while the impurity contact is strongly peaked at
positive scattering length, it remains always finite. Our solution
highlights how Bose polarons are self-stabilized by repulsion,
providing a mechanism to understand quench dynamics and
nonequilibrium time evolution at strong coupling.
Carroll Expansion of General Relativity
Authors: Hansen Dennis , Obers Niels , Oling Gerben , Søgaard Benjamin T.
Published: September 2022

We study the small speed of light expansion of general relativity, utilizing the modern perspective on non-Lorentzian geometry.
This is an expansion around the ultra-local Carroll limit, in which light cones close up.
To this end, we first rewrite the Einstein--Hilbert action in pre-ultra-local variables, which is closely related to the 3+1 decomposition of general relativity.
At leading order in the expansion, these pre-ultra-local variables yield Carroll geometry and the resulting action describes the electric Carroll limit of general relativity.
We also obtain the next-to-leading order action in terms of Carroll geometry and next-to-leading order geometric fields.
The leading order theory yields constraint and evolution equations, and we can solve the evolution analytically.
We furthermore construct a Carroll version of Bowen--York initial data, which has associated conserved boundary linear and angular momentum charges.
The notion of mass is not present at leading order and only enters at next-to-leading order.
This is illustrated by considering a particular truncation of the next-to-leading order action, corresponding to the magnetic Carroll limit, where we find a solution that describes the Carroll limit of a Schwarzschild black hole.
Finally, we comment on how a cosmological constant can be incorporated in our analysis.
Justicia social: concepto y acercamiento a pasajes de los profetas del siglo VIII a.C.
Authors: Molano Cortés Héctor Hernán
Published: September 2022

La justicia social es un tema vigente, sobre todo en los países latinoamericanos en donde las injusticias hacen parte de la cotidianeidad. Para el cristianismo, el texto bíblico habla a todas las esferas de la vida y para la Justicia Social tiene bastante que decir. En este artículo se estudia el concepto de Justicia Social desde los profetas del siglo VIII a.C., teniendo en cuenta las palabras hebreas de base, así como una exploración a textos escogidos de aquellos profetas. La conclusión anima a que el cristianismo esté cada vez más comprometido con esta temática.
Effect of board characteristics and risk management practices on the financial performance of listed non-financial firms in Nigeria
Authors: Mustapha Abu Martins , Abbas Ibrahim Umar , Adewale Muritala Taiwo
Published: September 2022

Faulty board configurations associated with risk management practices are alleged to be the primary sources of most corporate failures. Therefore, experts have suggested that firms should adopt holistic risk management practices. This study investigates the interactive effect of board characteristics with risk management activities on the performance of listed Nigerian non-financial firms. The study is anchored on the agency theory perspective. It is designed as ex post facto inquiry with a population of 113 companies, from which a sample of 96 firms was drawn from firms with a complete set of data. Secondary data were extracted from the NSE Factbook and Thomson Reuter’s DataStream for 2010–2019. The static panel regression technique was utilized to analyze and estimate the interaction between the variables. The findings show that all the independent variables positively impacted ROA of the listed firms. Nevertheless, concerning market evaluation (Tobin-Q), except for board financial experts and audit committee meetings, risk management committee meetings and the presence of chief risk officer showed an insignificant impact. The combined implication is that although firms have complied with the provision of the CG codes on risk governance structure, the improvements associated with risk management aimed at enhancing market evaluation are nonetheless not deeply embedded in these firms. Firms are suggested to implement effective risk management practices to achieve competitive advantages and substantiality. More studies are advocated to extend the literature by expanding the scope.
Assessment of limited downstream nitrate dosing for sulphide control in pressure sewers: case study in Germany
Authors: Despot Daneish , Reinhold Luisa , Barjenbruch Matthias
Published: September 2022

Odour release from sewer systems is an established environmental issue affecting many cities worldwide. A key indicator for the severity of the odour problem in sewer systems is linked to the amount of sulphide produced and released as hydrogen sulphide (H2S) into the urban environment. For this reason, an in-depth understanding of the biochemical processes of sulphurous compounds in sewer systems is an underlying base point for designing and implementing odour control strategies for sewer systems. This contribution focuses on a field study on the monitoring and assessing chemical dosing on a 9.0 km pressure sewer in Ueckermünde, Germany. Online H2S measurements indicated a daily reoccurrence of sulphide spikes between 4:00 and 8:00 am during the monitoring period. During this period, the wastewater slugs exiting the sewer section remained in the dosed section of the pipe the longest, and regeneration of sulphide production began after 3 hours, causing the hydrogen sulphide spikes. The proposed dosing strategy provides a cost-effective and efficient solution for sulphide build-up in long pressure sewers that connect rural areas to centralised wastewater collection and treatment systems.
Isotonic proportional hazard model for breast cancer patients
Authors: PASİN Ozge , ANKARALI Handan
Published: September 2022

Aim: There are many survival analysis methods in oncological studies. Each model is used in different data structures. The isotonic proportional hazard model is a survival model among these methods. The use of isotonic models is proposed to evaluate the relationship between time to event outcome and monotonically increasing covariate in survival analysis. The aim of this study is to explain the theoretical properties and usage of isotonic models and demonstrate their application on an appropriate dataset.Methods: Data on breast cancer patients treated at Seoul National University Hospital was used to make the application of isotonic models. In the modeling of recurrence risk, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and proliferation marker (Ki-67) variables were considered as independent risk factors. The tumor size was included in the model as covariate. The isotonic proportional hazard model was used in modeling. Estimation of model coefficients was made by partial likelihood method. Results: The tumor size had monotone increasing effect on recurrence events. It was determined that the risk of recurrence increased 1.008 times as the value of Ki-67 increased. It has been observed that ER and PR negativity increase the risk, while HER2 positivity increases the risk.Conclusion: As a result, in cases where the covariate variable has a monotone increasing effect on the disease process, the isotonic regression model can be used by considering the relationships between the covariate and the event. Thus, the function that takes into account the monotone relationship between the covariate and the event will be included in the survival analysis.
Conventional Methods for Removal of Emerging Water Pollutants
Authors: Tripathi Manoj , Verma Akanksha
Published: September 2022

Water is essential for life and no creature can survive without clean and
usable water. Most water is unusable as it contains salts and many other organic and
inorganic impurities. Without taking these impurities out, the water available to us
cannot be used. Different techniques can be adapted to purify the water and make it
usable. The selection of the water purification technique can be made depending upon
the water contamination, its loading, and other parameters. Based on the contamination
and other parameters, chemical or physical techniques for water purification can be
applied. Disinfection, desalination, coagulation, and chemical precipitation are
common chemical methods used for water purification. For adsorption, membrane
filtration is used to filter the pollutant out physically. Various char-based materials are
synthesized and used for water purification using the adsorption route. Highly porous
char materials can contain the contaminants into their pores and allow the clean water
to pass through. The overflow of the adsorbent with the pollutant can be solved by
using magnetic biochar as the contaminants can be taken out of the magnetic char based adsorbent and reused. Thus, the process becomes more effective and efficient.
The chapter talks about these processes and their limitations, and advantages over the
others. It also describes different types of materials used for the water purification
processes.
Are traditional head size and shape measurements useful in modern medical design? A literature review
Authors: Rex Binder Jonathan , Unver Ertu , Ivan Cardoso Huerta Omar
Published: September 2022

Scalp cooling is a clinically proven treatment for addressing chemotherapy-induced alopecia (CIA). Previous studies show that the efficacy of this treatment relies on accurate cranial data so that designers can produce close-fitting scalp cooling caps. The cephalic index is often used, but are that data still accurate? In this literature review, we identified and explored previous studies concerning head size and shape with the goal of identifying shortcomings for design purposes. The literature review indicates that a more suitable method is needed to collect data to enable mass customisation of scalp cooling caps. Head data are more complex for design.
Caffeine. A critical review of contemporary scientific literature
Authors: Portillo Ostilio R. , Arévalo Ana C.
Published: September 2022

Caffeine is a secondary metabolite extensively studied for its stimulatory properties and presumed association with specific pathologies. This alkaloid is typically consumed through coffee, tea, and other plant products but is also an additive in many medications and confectionaries. Nonetheless, despite its worldwide consumption and acceptance, there is controversial evidence as to whether its effects on the central nervous system should be interpreted as stimulatory or as an addiction in which typical withdrawal effects are canceled out with its daily consumption. The following discussion is the product of an extensive review of current scientific literature, which aims to describe the most salient topics associated with caffeine's purpose in nature, biosynthesis, metabolism, physiological effects, toxicity, extraction, industrial use and current plant breeding approaches for the development of new caffeine deficient varieties as a more economical option to the industrially decaffeinated coffees currently available to caffeine intolerant consumers.

Keywords: biosynthesis, decaffeination, extraction, metabolism, physiological effects, plant breeding.
Empleo de Hidróxidos Dobles Laminares como material adsorbente en el tratamiento de aguas contaminadas por ácido pícrico, experiencia realizada en la UNAH año 2018
Authors: Rodríguez Fredy , Rodríguez Heydi
Published: September 2022

La contaminación de fuentes de agua por la industria química es uno de los graves problemas medioambientales y, por ende, de salud que atraviesa la humanidad. El objetivo del siguiente trabajo fue determinar la capacidad descontaminante de un conjunto de nanopartículas conocidas comúnmente como hidróxidos dobles laminares (HDL) o compuesto de tipo hidrotalcita (HT). Se realizó la síntesis de los mismos y la posterior caracterización por espectroscopía infrarroja con el fin de analizar su capacidad como material adsorbente en tratamiento de aguas contaminadas por ácido pícrico en la Facultad de Química y Farmacia de la Universidad Nacional Autónoma de Honduras (UNAH) en los meses comprendidos de marzo a julio del 2018. Para el estudio se utilizó la técnica de análisis de colorimetría para la determinación de las cantidades adsorbidas por los HDL y el descenso de concentraciones iniciales de las soluciones. La información obtenida se procesó y los resultados fueron expresados en términos numéricos y porcentuales, así como en gráficos. Los resultados mostraron que el mayor descenso de la concentración de la solución de ácido pícrico y, por consiguiente, la mayor cantidad del mismo retenido en la superficie del material adsorbente sintetizado, se alcanzó a las 2 horas de contacto con agitación constante, demostrando su capacidad descontaminante como un material adsorbente de fácil y económica preparación.

Palabras clave: contaminación de agua, remediación ambiental, adsorbentes, tratamiento de agua, adsorción
Sarcoidosis extrapulmonar en tatuaje como forma de presentación sistémica; reporte de un caso
Authors: Letona-García Nimzy J.Z. , Vasquez-Bonilla Walter O. , Monroy Alexis , Velasquez Rosario , Medina Pe-bbles , Muñoz-Lara Fausto
Published: September 2022

La sarcoidosis es una enfermedad inflamatoria multisistémica granulomatosa, no necrotizante de etiología desconocida, su diagnóstico es clínico-patológico. Su incidencia se estima entre 2.3 y 11 por 100.000 habitantes/año y prevalencia varía de 2.17 a 160 por 100.000 personas, comienza en adultos menores de 50 años, pero se ha visto que alrededor del 70% de los casos ocurren entre los 25 y los 40 años en el momento de la presentación, con un segundo pico de incidencia en mujeres mayores de 50 años. Se presenta paciente masculino de 41 años, afroamericano, procedente de la región Nor-Oriental de Guatemala y residente en la ciudad de Guatemala, sin comorbilidades, con dermatosis caracterizada por: múltiples neoformaciones papuliformes, firmes de 3 a 4 mm de diámetro, de color negruzco, asociadas a prurito constante sin predominio de horario sobre tatuaje en miembro superior izquierdo, de dos años de evolución, sin fiebre, diaforesis nocturna, ni pérdida de peso, no recibió atención medica previamente. Exámenes de laboratorio sin alteraciones, to-mografía axial computarizada de pulmones sin afectación del parénquima pulmonar, análisis microbiológicos para tuberculosis fueron negativos, serología para: VIH, hepatitis A, B y C fueron negativas, VDRL no reactivo. Se le realiza biopsia incisional en sacabocados de 4 mm de piel del área del tatuaje, la histopatología reporto piel con inflamación crónica granulomatosa con for-mación de granulomas pequeños uniformes, con presencia de células gigantes de tipo cuerpo ex-traño, dentro de las cuales se observan cuerpos asteroides pequeños, tinción de Ácido periódico de Schiff (PAS) y Kinyoun fueron negativas para microrganismos, se llegó al diagnóstico de sarcoi-dosis extrapulmonar en piel. El diagnóstico de sarcoidosis se requiere un cuadro clínico sugestivo, la comprobación histopatológica de granulomas no caseificantes en los órganos afectos y la exclu-sión de otras enfermedades capaces de producir hallazgos histopatológicos, o clínicos similares.

Palabras claves: Granulomas, Manifestaciones cutáneas, Sarcoidosis.
Los Recuerdos del claustro, por fray Luis Malo: una crónica franciscana olvidada del siglo XIX
Authors: Ramírez López Javier Eduardo
Published: September 2022

La obra Recuerdos del claustro fue escrita por el franciscano fray Luis Malo y ha permanecido inédita; dicho texto es una crónica sobre el proceso de nacionalización de los conventos franciscanos en la Provincia del Santo Evangelio de México en la década de 1860. Luis Malo fue testigo ocular de lo que vivieron los religiosos al aplicarse la Ley de Nacionalización de Bienes Eclesiásticos, además de haber visitado distintos conventos antes de que fueran propiedad del Estado; también pudo intercambiar información sobre el tema con otros frailes cuando fungió como secretario de la Provincia del Santo Evangelio de México.
“El texto mixto: periódico-libro y maneras de construir el sentido”. La Gazeta de literatura de México (1788-1795) como periódico-libro. Estudio bibliográfico
Authors: Ortega Pinelo Aura Estefanía
Published: September 2022

Reseña de:La Gazeta de literatura de México (1788-1795) como periódico-libro. Estudio bibliográfico. Dalia Valdez Garza. México: Universidad Nacional Autónoma de México / Instituto Tecnológico y de Estudios Superiores de Monterrey / Historiadores de las Ciencias y las Humanidades, 2020, 260 pp. ISBN: 978-607-30-2848-6.
Entre lo regional y lo nacional: dos apropiaciones modernas de la Historia de Tlaxcala, de Diego Muñoz Camargo
Authors: Amaral-Rodríguez Jannette
Published: September 2022

Estudio comparativo de los marcos político-ideológicos que influyeron en la producción de dos ediciones modernas de Historia de Tlaxcala, texto fundamental del canon colonial de la literatura e historia mexicanas. Estas ediciones (Tlaxcala, 1870; México, 1892) tuvieron destinos desiguales: la de 1870 permaneció casi desconocida, en tanto que la de 1892 –editada por Alfredo Chavero– fue la más consultada por expertos durante más de un siglo, tanto en México como internacionalmente, a pesar de estar incompleta. Este artículo hace una serie de propuestas: 1) Es fundamental conocer el contexto histórico de producción de ambas ediciones para entender su recepción y valor para las disciplinas que estudian el periodo colonial mexicano; 2) Su producción en el siglo XIX está conectada por tensiones entre intereses políticos regionales y federales que usaron la herencia tlaxcalteca como ficha patriótica o nacionalista en discursos modernizadores; 3) Estos intereses determinaron cómo fue tratado el texto de la Historia de Tlaxcala.
"Escribir sobre la escritura de arte. Desafíos para la crítica y la creación". Escritores de imágenes y pintores de discursos. Literatura y crítica de arte en la prensa cultural de México (1900-1930)
Authors: Giovine Yáñez María Andrea
Published: September 2022

Reseña de:Escritores de imágenes y pintores de discursos. Literatura y crítica de arte en la prensa cultural de México (1900-1930). Fernando Ibarra Chávez. Heúresis. México: Universidad Nacional Autónoma de México, Facultad de Filosofía y Letras, Dirección General de Asuntos del Personal Académico, 2020, 297 pp. PDF. ISBN: 978-607-30-3590-3.
Un excepcional pliego suelto de la Hispanic Society: la Invectiva contra el heresiarcha Luthero, de Cristóbal Mansilla (RM 335.5)
Authors: Gamba Corradine Jimena
Published: September 2022

En la Hispanic Society of America se conserva el único ejemplar de un pliego suelto bastante excepcional, publicado en Burgos (1552) en la prensa de Juan de Junta: se trata de la única invectiva conocida del siglo XVI, y escrita en vernáculo, contra Martín Lutero. El presente artículo estudia y edita este texto. En primer lugar, se aborda la historia del impreso, cuyo paradero fue identificado por Antonio Pérez y Gómez hacia 1960, y se contextualiza en el marco de la producción de pliegos sueltos similares de la época. En segundo lugar, se realiza un análisis literario de esta invectiva que expone los vínculos que tiene con el Ibis ovidiano –y, de este modo, con la tradición de la invectiva clásica–, así como con la tradición bíblica, importantísima en el texto para ejemplificar los numerosos tipos de muerte que el autor le desea al reformador.
“Hay una vida mística enlazada” al siglo XIX mexicano: las “Stanzas to Jessy” de Lord Byron en dos traducciones al español
Authors: Mora Triay María Fernanda
Published: September 2022

Desde 1985 se discute la injerencia de los elementos ortotipográficos, los procesos de transmisión, producción y recepción de los textos para la bibliografía, la historia de la lectura y la crítica textual, con objeto de atenderlos como formas históricamente registradas. De esta suerte, el estudio de objetos lingüísticos no librarios, difundidos principalmente en la prensa periódica, ha cobrado especial relevancia. Sin embargo, las repercusiones y formas de transmisión de traducciones e imitaciones literarias durante el siglo XIX mexicano no han sido lo suficientemente exploradas. Este artículo se propone la recuperación de un poema, “Stanzas to Jessy” de George Gordon Byron, para comprender sus canales de distribución, apropiación e inserción dentro de la literatura mexicana decimonónica.
Advertencia editorial
Authors: Godinas Laurette , Mercado Noyola Francisco Rodolfo
Published: September 2022

Presentación de la portada, banner y contenido del número actual de Bibliographica.
Dynamic Simulation and Process Design Analysis of Syngas Purification and The Utilization of Gas Permeation
Authors: Fidelis Wopara Onuoha , Johnson Nnadikwe , Dozie Ewelike Asterius , Chidubem Udechukwu Mathew
Published: September 2022

Abstract: Syngas generation from alternative energy sources, notable methanation, is currently gaining popularity. The technique saves energy by converting it into a chemical product. It is not suited for use directly in distribution grids, where a greater purity of methane is necessary for maximum power density. Various syngas purification levels should be supplied for various methane grades (for heat, power, and automotive fuels uses). Water damages the mechanical components of an engine, thus it must be removed before it can be utilized as a fuel. CO2 removal should also be performed to increase methane heat quality and minimize pollution. This research evaluated the performance of a syngas purification system using a flash separator and hollow fiber membranes. A flash separator model condensed the water from the wet feed. The CO2 removal from methane was then investigated using hollow fiber membranes. As a consequence, Aspen Plus® V8.6 includes a FORTRAN user model for unit operations. The greatest result was filtering methane up to 98 percent vol. using a two stage pervaporation system with recycling streams. The model scheme may help in the implementation and quality evaluation of a complex methanation plant system
Data Analytics on the Interagency Task Force Health Protocol Violators: Tracing the Trends and Determining Future Violations using Time Series and ARIMA (1, 0, 1) model
Authors: Jr Zenon A. Matos , Ybanez Elsie S. , Orong Markdy Y.
Published: September 2022

Abstract: The Interagency Task Force (IATF) is the agency that is responsible for ensuring the safety of every individual amidst COVID-19 pandemic. The agency has in placed the minimum health protocols for the community to adhere with as a way of ensuring safety among individual. This study determined the trends of violations committed against the minimum health standards and provides predicted data of its violations. The time series analysis and quantile regression are used for trend analysis and forecasting. The study will provide inputs to the authority as benchmark of their intervention plans in mitigating the violations against health protocol imposed by the national and local government.
PRÁCTICAS EVALUATIVAS EN LA FORMACIÓN INICIAL DE DOCENTES: UN ESTUDIO SELF STUDY COLABORATIVO
Authors: Villagra Bravo Carolina , Mellado Hernández María Elena , Leiva Guerrero María Veronica , Sepúlveda Silva Segundo
Published: September 2022

Las políticas actuales en Chile sobre formación docente exigen transformaciones a nivel estructural en las prácticas evaluativas. El objetivo del artículo es describir el proceso de resignificación y transformación de la propia práctica evaluativa del formador mediante la re- flexión y colaboración entre amigos críticos. La metodología utilizada fue Self Study, participan de este estudio 4 docentes formadores de profesores de tres universidades chilenas, quienes conformaron una comunidad de aprendizaje entre amigos críticos que reflexionan sobre sus prácticas de evaluación formativa a nivel individual y colectivo. Los diálogos pedagógicos entre formadores llevaron a dilucidar nudos críticos entre el discurso y la práctica evaluativa, dicha tensión develó la concepción de aprendizaje y evaluación formativa que subyace a la práctica docente. Dichos resultados permiten concluir que el análisis sistemático de la práctica evalua- tiva aporta a la transformación de la cultura de aprendizaje en la formación del profesorado
Topological Conjugacy of Gradient-Like Flows on Surfaces and Efficient Algorithms for Its Distinguition
Authors: Kruglov V. E. , Pochinka O. V.
Published: September 2022

Gradient-like flows on surfaces have simple dynamics, which inspired many mathematicians to search for invariants of their topological equivalence. Under assumptions of different generality on the class of gradient-like flows under consideration, such classical invariants as the Leontovich- Mayer scheme, the Peixoto graph, the equipped Peixoto graph, the two-color Wang graph, the threecolor Oshemkov-Sharko graph, the Fleitas circular scheme, etc. were obtained. Thus, the problem of classifying gradient-like flows on surfaces from the point of view of topological equivalence has been solved in an exhaustive way. In recent works by Kruglov, Malyshev, and Pochinka, it was proved that for gradient-like flows the topological equivalence classes coincide with the topological conjugacy classes. The obtained result allows us to use any invariants of their equivalence for topological conjugacy of gradient-like flows. The present study is a review of the results on topological conjugacy of gradient-like flows on surfaces and efficient algorithms for its distinguishing, that is, algorithms whose running time is limited by some polynomial on the length of the input information.
Off-eutectic growth model for solidifying alloy from undercooled state
Authors: Xu Junfeng , Galenko Peter
Published: September 2022

The classical eutectic growth models are based on the use of eutectic
composition. These models neglect the effect of the primary phase
formation and their direct using in the rapid solidification process of
off-eutectic (hypoeutectic and hypereutectic) alloys is absent. Combing
the effect of the primary phase in the eutectic transformation and an
off-eutectic composition, the solidification growth model is derived in
the present work. The effect of the model and materials parameters on
solidification kinetics is discussed in comparison with experimental
data. Computational results on the off-eutectic growth model show that
the model agrees well with experimental data on solidification kinetics
of Ni-B and Ti-Si alloys.
Gearing Towards Pediatric Healthcare in Africa: Focus on the Outbreak of Acute Hepatitis of Unknown etiology
Authors: Paul Innocent , Nchasi Goodluck , Mallya : Margareth , Basinda Matilda , Sospeter Sospeter , Ruaichi Juvenali , Udohchukwu Okereke
Published: September 2022

The Outbreak of Acute hepatitis of unknown etiology has affected
children drawing the attention of authorities to investigate the cause.
Africa hasn’t reported any case yet but isn’t guaranteed safety unless
there’re efforts employed. This work focused on the efforts which would
be adapted in Africa prior the outbreak occurs.
Adenosine stress myocardial contrast stress echocardiograph in patient with Acute Non-ST-segment myocardial infarction : a case report with long-term follow-up and guide treatment
Authors: Li Jia , Duan Xiaoxu , Yu Jiahui
Published: September 2022

MCSE have been gradually applied in clinical practice. However, how to
flexibly apply it to the diagnosis and treatment of CAD still needs
clinical practice. Herein, we encountered a case of NSTEMI patient, who
perform MCSE three times to assist in finding the pathogenesis and
guiding medication
A complete genome of Bathymodiolus thermophilus thioautotrophic symbiont reveals a unique hydrogenase operon among hydrothermal vent mussel symbionts
Authors: Patra Ajit Kumar , PEREZ Maeva , Jang Sook-Jin , Won Yong-Jin
Published: September 2022

The mytilid mussel Bathymodiolus thermophilus lives in the deep-sea
hydrothermal vent regions due to its symbiotic relationship with
chemosynthetic Gammaproteobacteria species which reside inside
specialized gill cells. The symbionts in the gill bacteriocytes oxidize
the reduced sulfur amply available in the vent environment. Here we
sequenced and assembled the complete genome of a gill symbiont sampled
from an individual mussel from the East Pacific Rise (EPR9N), using
PacBio sequencing technology. The final symbiont assembly consists of a
single contig size of 2.83 Mb, with a GC content of 38.6% and encodes
for 2,133 protein-coding genes. CRISPR diversity analysis confirmed this
genome originated from a single symbiont strain. Comparative analysis
revealed 2,554 core gene clusters were shared with other B. thermophilus
thiotrophic gill symbiont genomes, whereas 125 were unique to this EPR9N
strain. In addition, we found that EPR9N strain has a unique hydrogenase
operon among Bathymodiolus mussels consisting of additional H2-sensing
hydrogenase subunits and a histidine kinase gene. Also, we found
methylated regions sparsely distributed throughout the EPR9N genome,
mainly in the transposases regions and densely present in the rRNA gene
regions. Variation in genome size, gene content and genome
re-arrangements across individual hosts suggest multiple symbiont
strains can associate with B. thermophilus. This complete mussel
symbiont genome will be invaluable for further comparative genomic
analyses studying structural genome evolution, symbiont population
diversity, and symbiont ecology in deep-sea chemosynthetic environments.