bluuebunny/crossref_metadata_2025 huggingface dataset:
An Ontological Approach to Enhancing Information Sharing in Disaster Response
Authors: Elmhadhbi Linda , Karray Mohamed-Hedi , Archimède Bernard , Otte J. Neil , Smith Barry
Published: October 2021

Managing complex disaster situations is a challenging task because of the large number of actors involved and the critical nature of the events themselves. In particular, the different terminologies and technical vocabularies that are being exchanged among Emergency Responders (ERs) may lead to misunderstandings. Maintaining a shared semantics for exchanged data is a major challenge. To help to overcome these issues, we elaborate a modular suite of ontologies called POLARISCO that formalizes the complex knowledge of the ERs. Such a shared vocabulary resolves inconsistent terminologies and promotes semantic interoperability among ERs. In this work, we discuss developing POLARISCO as an extension of Basic Formal Ontology (BFO) and the Common Core Ontologies (CCO). We conclude by presenting a real use-case to check the efficiency and applicability of the proposed ontology.
Update on Male Infertility
Authors: Bardhi Erlisa , Drakopoulos Panagiotis
Published: October 2021

Infertility, defined as the failure to conceive after one year of regular intercourse without the use of contraception, in women less than 35 years of age remains a unique medical condition, as it involves a couple rather than a single individual [...]
Effect of Dipeptidyl Peptidase-4 Inhibitors on Bone Health in Patients with Type 2 Diabetes Mellitus
Authors: Lee Dong-Hwa , Kim Kyong Young , Yoo Min Young , Moon Hansol , Ku Eu Jeong , Oh Tae Keun , Jeon Hyun Jeong
Published: October 2021

Patients with type 2 diabetes (T2DM) have a higher risk of bone fracture even when bone mineral density (BMD) values are normal. The trabecular bone score (TBS) was recently developed and used for evaluating bone strength in various diseases. We investigated the effect of DPP-4 inhibitors on bone health using TBS in patients with T2DM. This was a single-center, retrospective case-control study of 200 patients with T2DM. Patients were divided into two groups according to whether they were administered a DPP-4 inhibitor (DPP-4 inhibitor group vs. control group). Parameters related to bone health, including BMD, TBS, and serum markers of calcium homeostasis, were assessed at baseline and after one year of treatment. We found TBS values increased in the DPP-4 group and decreased in the control, indicating a significant difference in delta change between them. The BMD increased in both groups, with no significant differences in delta change between the two groups observed. Serum calcium and 25-hydroxy vitamin D3 increased only in the DPP-4 inhibitor group, while other glycemic parameters did not show significant differences between the two groups. Treatment with DPP-4 inhibitors was associated with favorable effects on bone health evaluated by TBS in patients with T2DM.
Is Irritable Bowel Syndrome Considered as Comorbidity in Clinical Trials of Physical Therapy Interventions in Fibromyalgia? A Scoping Review
Authors: Rodríguez-Castillejo Paula Mª , Fernández-de-las-Peñas César , Alburquerque-Sendín Francisco , Rodrigues-de-Souza Daiana P.
Published: October 2021

Evidence supports the presence of comorbid conditions, e.g., irritable bowel syndrome (IBS), in individuals with fibromyalgia (FM). Physical therapy plays an essential role in the treatment of FM; however, it is not currently known whether the IBS comorbidity is considered in the selection criteria for clinical trials evaluating physiotherapy in FM. Thus, the aim of the review was to identify whether the presence of IBS was considered in the selection criteria for study subjects for those clinical trials that have been highly cited or published in the high-impact journals investigating the effects of physical therapy in FM. A literature search in the Web of Science database for clinical trials that were highly cited or published in high-impact journals, i.e., first second quartile (Q1) of any category of the Journal Citation Report (JCR), investigating the effects of physical therapy in FM was conducted. The methodological quality of the selected trials was assessed with the Physiotherapy Evidence Database (PEDro) scale. Authors, affiliations, number of citations, objectives, sex/gender, age, and eligibility criteria of each article were extracted and analyzed independently by two authors. From a total of the 412 identified articles, 20 and 61 clinical trials were included according to the citation criterion or JCR criterion, respectively. The PEDro score ranged from 2 to 8 (mean: 5.9, SD: 0.1). The comorbidity between FM and IBS was not considered within the eligibility criteria of the participants in any of the clinical trials. The improvement of the eligibility criteria is required in clinical trials on physical therapy that include FM patients to avoid selection bias.
Oxidative Stress Induced by Reactive Oxygen Species (ROS) and NADPH Oxidase 4 (NOX4) in the Pathogenesis of the Fibrotic Process in Systemic Sclerosis: A Promising Therapeutic Target
Authors: Piera-Velazquez Sonsoles , Jimenez Sergio A.
Published: October 2021

Numerous clinical and research investigations conducted during the last two decades have implicated excessive oxidative stress caused by high levels of reactive oxygen species (ROS) in the development of the severe and frequently progressive fibrotic process in Systemic Sclerosis (SSc). The role of excessive oxidative stress in SSc pathogenesis has been supported by the demonstration of increased levels of numerous biomarkers, indicative of cellular and molecular oxidative damage in serum, plasma, and other biological fluids from SSc patients, and by the demonstration of elevated production of ROS by various cell types involved in the SSc fibrotic process. However, the precise mechanisms mediating oxidative stress development in SSc and its pathogenetic effects have not been fully elucidated. The participation of the NADPH oxidase NOX4, has been suggested and experimentally supported by the demonstration that SSc dermal fibroblasts display constitutively increased NOX4 expression and that reduction or abrogation of NOX4 effects decreased ROS production and the expression of genes encoding fibrotic proteins. Furthermore, NOX4-stimulated ROS production may be involved in the development of certain endothelial and vascular abnormalities and may even participate in the generation of SSc-specific autoantibodies. Collectively, these observations suggest NOX4 as a novel therapeutic target for SSc.
Recurrence of Gestational Diabetes Mellitus: To Assess Glucose Metabolism and Clinical Risk Factors at the Beginning of a Subsequent Pregnancy
Authors: Kotzaeridi Grammata , Blätter Julia , Eppel Daniel , Rosicky Ingo , Falcone Veronica , Adamczyk Gabriela , Linder Tina , Yerlikaya-Schatten Gülen , Weisshaupt Karen , Henrich Wolfgang , Tura Andrea , Göbl Christian S.
Published: October 2021

Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing hyperglycemia in a subsequent pregnancy. This study aimed to assess parameters of glucose metabolism at the beginning of a subsequent pregnancy in women with a history of GDM. This prospective cohort study included 706 women who had at least one previous pregnancy (120 with prior GDM and 586 without GDM history). All study participants received a broad risk evaluation and laboratory testing at the beginning of a subsequent pregnancy and were followed up until delivery to assess GDM status, risk factors for GDM recurrence, and pregnancy outcomes. Women with a history of GDM exhibited lower insulin sensitivity and subtle impairments in β-cell function associated with subclinical hyperglycemia already at the beginning of a subsequent pregnancy compared to women without GDM history. This was associated with a markedly increased risk for the later development of GDM (OR: 6.59, 95% CI 4.34 to 10.09, p < 0.001). Early gestational fasting glucose and HbA1c were identified as the most important predictors. Mothers with a history of GDM showed marked alterations in glucose metabolism at the beginning of a subsequent pregnancy, which explains the high prevalence of GDM recurrence in these women.
Update on Pulmonary Ossifications in the Differential Diagnosis of Solitary Pulmonary Nodules
Authors: Gielis Jan F. , Berzenji Lawek , Siozopoulou Vasiliki , Luijks Marloes , Van Schil Paul E. Y.
Published: October 2021

Pulmonary ossifications have often been regarded as rare, post-mortem findings without any clinical significance. We have investigated the occurrence of pulmonary ossifications in patients undergoing thoracic procedures, and how this may affect the differential diagnosis of solitary pulmonary nodules. In addition, we have performed a literature search on the occurrence and possible pathogenesis of these ossifications. From January 2008 until August 2019, we identified pulmonary ossifications in 34 patients who underwent elective pulmonary surgery. Pre-operative imaging was unable to differentiate these ossifications from solid tumors. A definitive diagnosis was made by an experienced pathologist (VS, ML). The PubMed database was researched in December 2019 with the search terms “pulmonary ossifications”; “heterotopic ossifications”; and “solitary pulmonary nodule”. In total, 27 patients were male, with a mean age of 63 ± 12 years (age 41 to 82 on diagnosis). All lesions were identified on thoracic CT and marked for resection by a multidisciplinary team. A total of 17 patients were diagnosed with malignancy concurrent with ossifications. There was a clear predilection for the right lower lobe (12 cases, 35.3%) and most ossifications had a nodular form (70.6%). We could not identify a clear association with any other pathology, either cancerous or non-cancerous in origin. Oncologic or pulmonary comorbidities did not influence patient survival. Pulmonary ossifications are not as seldom as thought and are not just a curiosity finding by pathologists. These formations may be mistaken for a malignant space-occupying lesion, both pre-and perioperatively, as they are indistinguishable in imaging. We propose these ossifications as an underestimated addition to the differential diagnosis of a solitary pulmonary nodule.
Infection of Human Cells by SARS-CoV-2 and Molecular Overview of Gastrointestinal, Neurological, and Hepatic Problems in COVID-19 Patients
Authors: Rahban Mahdie , Stanek Agata , Hooshmand Amirreza , Khamineh Yasaman , Ahi Salma , Kazim Syed Naqui , Ahmad Faizan , Muronetz Vladimir , Samy Abousenna Mohamed , Zolghadri Samaneh , Saboury Ali A.
Published: October 2021

The gastrointestinal tract is the body’s largest interface between the host and the external environment. People infected with SARS-CoV-2 are at higher risk of microbiome alterations and severe diseases. Recent evidence has suggested that the pathophysiological and molecular mechanisms associated with gastrointestinal complicity in SARS-CoV-2 infection could be explained by the role of angiotensin-converting enzyme-2 (ACE2) cell receptors. These receptors are overexpressed in the gut lining, leading to a high intestinal permeability to foreign pathogens. It is believed that SARS-CoV-2 has a lesser likelihood of causing liver infection because of the diminished expression of ACE2 in liver cells. Interestingly, an interconnection between the lungs, brain, and gastrointestinal tract during severe COVID-19 has been mentioned. We hope that this review on the molecular mechanisms related to the gastrointestinal disorders as well as neurological and hepatic manifestations experienced by COVID-19 patients will help scientists to find a convenient solution for this and other pandemic events.
The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
Authors: Lee Chung Un , Choi Joongwon , Sung Si Hyun , Chung Jae Hoon , Song Wan , Kang Minyong , Sung Hyun Hwan , Jeong Byong Chang , Seo Seong Il , Jeon Seong Soo , Lee Hyun Moo , Jeon Hwang Gyun
Published: October 2021

Background: To identify the role of combination biopsy, which consists of both targeted and additional systematic cores, in the diagnosis of clinically significant prostate cancer (csPCa). Methods: We retrospectively reviewed patients with PSA levels 2.5–15 ng/mL who have a suspicious prostate lesion (with the Prostate Imaging Reporting and Data System (PI-RADS) ≥ 3) on multiparametric MRI (mpMRI) between January 2016 and December 2018. We analyzed biopsy results by PI-RADS score and biopsy methods (systematic, targeted, and combination biopsy). Results: Of the 711 total patients, an average of 4.0 ± 1.8 targeted and 8.6 ± 3.1 additional systematic biopsies were performed. The additional systematic biopsies were sampled outside the targeted biopsy area. The combination biopsies detected more csPCa (201 patients, 28.3%) than did the targeted (175 patients, 24.6%) or systematic (124 patients, 17.4%) biopsies alone (p < 0.001). In the initial biopsy samples, there was a 7% increase in the detection of csPCa than in targeted biopsy (62% to 69%). It increased by 11% in repeat biopsy (46% to 57%). There was no statistical significance in both groups (p = 0.3174). Conclusions: Combination biopsy has the benefit of detecting csPCa in both initial and repeat biopsy when there is a suspicious lesion on mpMRI.
Pipeline Pressure Loss in Deep-Sea Hydraulic Systems Considering Pressure-Dependent Viscosity Change of Hydraulic Oil
Authors: Wu Jia-Bin , Li Li
Published: October 2021

The high ambient pressure in deep-sea conditions greatly increases the viscosity of hydraulic oil and then the pipeline pressure loss in deep-sea hydraulic systems. Large pipeline pressure loss can lead to a further change of viscosity on the basis of the viscosity increase caused by the ambient pressure when the hydraulic oil flows through the pipeline. Therefore, the classic Poiseuille’s law can no longer accurately calculate the pipeline pressure loss in deep-sea conditions since it treats the viscosity as a constant. In this paper, based on laminar flow theory and the viscosity-pressure characteristics of hydraulic oil, a novel equation for pipeline pressure loss is proposed, in which the viscosity change when flowing through the pipeline is taken into account. A CFD (Computational Fluid Dynamics) model of a pipeline in the deep-sea hydraulic system has been established, and CFD simulations have been conducted to verify the correctness of the proposed equation for pipeline pressure loss. Theoretical analysis shows that the proposed novel equation for pipeline pressure loss is equivalent to the classic Poiseuille’s law when the pipeline pressure loss or the viscosity change is low. The research results in this paper can provide theoretical support for work efficiency optimization, load capacity improvement, and precise control of deep-sea operation equipment or deep-sea hydraulic systems.
Collision Risk Assessment Support System for MASS RO and VTSO Support in Multi-Ship Environment of Vessel Traffic Service Area
Authors: Yoo Yunja , Lee Jin-Suk
Published: October 2021

The discussions by the International Maritime Organization for the introduction of a maritime autonomous surface ship (MASS) began in earnest. At the 27th ENAV meeting, the International Association of Marine Aids to Navigation and Lighthouse Authorities proposed the “sharing of a common operating picture for situational awareness of the waterway within vessel traffic service (VTS) environment” when developing a system to support MASS operation. Marine accidents caused by collisions on waterways still account for a high percentage of ship accidents that occur at sea, and many studies have investigated the risk of collision between ships. Collision risk assessment was primarily conducted in ship domain-based safety areas. This study evaluates the collision risk using the ship domain derived by the VTS operator (VTSO) and proposes a real-time collision risk assessment support system to improve the situational awareness of VTSOs and MASS remote operators (MASS ROs) regarding near-collision situations occurring in local waters. To evaluate the validity of the proposed system, a risk analysis was performed on near-collision scenarios at Busan Port. The results show that the distance to the closest point of approach (CPA), time to the CPA, and inter-ship distance converged within 0.5 nautical miles, 10 min, and 3 nautical miles, respectively.
Suppressed Thermocline Mixing in the Center of Anticyclonic Eddy in the North South China Sea
Authors: Qi Yongfeng , Mao Huabin , Wang Xia , Yu Linhui , Lian Shumin , Li Xianpeng , Shang Xiaodong
Published: October 2021

Direct microstructure observations and fine-scale measurements of an anticyclonic mesoscale eddy were conducted in the northern South China Sea in July 2020. An important finding was that suppressed turbulent mixing in the thermocline existed at the center of the eddy, with an averaged diapycnal diffusivity at least threefold smaller than the peripheral diffusivity. Despite the strong background shear and significant wave–mean flow interactions, the results indicated that the lack of internal wave energy in the corresponding neap tide period during measurement of the eddy’s center was the main reason for the suppressed turbulent mixing in the thermocline. The applicability of the fine-scale parameterization method in the presence of significant wave–mean flow interactions in a mesoscale eddy was evaluated. Overprediction via fine-scale parameterization occurred in the center of the eddy, where the internal waves were inactive; however, the parameterization results were consistent with microstructure observations along the eddy’s periphery, where active internal waves existed. This indicates that the strong background shear and wave–mean flow interactions affected by the mesoscale eddy were not the main contributing factors that affected the applicability of fine-scale parameterization in the northern South China Sea. Instead, our results showed that the activity of internal waves is the most important consideration.
International Multicentre Study of Candida auris Infections
Authors: Pandya Nirav , Cag Yasemin , Pandak Nenad , Pekok Abdullah Umut , Poojary Aruna , Ayoade Folusakin , Fasciana Teresa , Giammanco Anna , Caskurlu Hulya , Rajani Dhanji P. , Gupta Yogesh Kumar , Balkan Ilker Inanc , Khan Ejaz Ahmed , Erdem Hakan
Published: October 2021

Background:Candida auris has emerged globally as a multi-drug resistant yeast and is commonly associated with nosocomial outbreaks in ICUs. Methods: We conducted a retrospective observational multicentre study to determine the epidemiology of C. auris infections, its management strategies, patient outcomes, and infection prevention and control practices across 10 centres from five countries. Results: Significant risk factors for C. auris infection include the age group of 61–70 years (39%), recent history of ICU admission (63%), diabetes (63%), renal failure (52%), presence of CVC (91%) and previous history of antibiotic treatment (96%). C. auris was commonly isolated from blood (76%). Echinocandins were the most sensitive drugs. Most common antifungals used for treatment were caspofungin (40%), anidulafungin (28%) and micafungin (15%). The median duration of treatment was 20 days. Source removal was conductedin 74% patients. All-cause crude mortality rate after 30 days was 37%. Antifungal therapy was associated with a reduction in mortality (OR:0.27) and so was source removal (OR:0.74). Contact isolation precautions were followed in 87% patients. Conclusions:C. auris infection carries a high risk for associated mortality. The organism is mainly resistant to most azoles and even amphotericin-B. Targeted antifungal therapy, mainly an echinocandin, and source control are the prominent therapeutic approaches.
Identification of Fungal Pathogens to Control Postharvest Passion Fruit (Passiflora edulis) Decays and Multi-Omics Comparative Pathway Analysis Reveals Purple Is More Resistant to Pathogens than a Yellow Cultivar
Authors: Rizwan Hafiz Muhammad , Zhimin Lin , Harsonowati Wiwiek , Waheed Abdul , Qiang Yang , Yousef Ahmed Fathy , Munir Nigarish , Wei Xiaoxia , Scholz Sandra S. , Reichelt Michael , Oelmüller Ralf , Chen Faxing
Published: October 2021

Production of passion fruit (Passiflora edulis) is restricted by postharvest decay, which limits the storage period. We isolated, identified, and characterized fungal pathogens causing decay in two passion fruit cultivars during two fruit seasons in China. Morphological characteristics and nucleotide sequences of ITS-rDNA regions identified eighteen isolates, which were pathogenic on yellow and purple fruit. Fusarium kyushuense, Fusarium concentricum, Colletotrichum truncatum, and Alternaria alternata were the most aggressive species. Visible inspections and comparative analysis of the disease incidences demonstrated that wounded and non-wounded yellow fruit were more susceptible to the pathogens than the purple fruit. Purple cultivar showed higher expression levels of defense-related genes through expression and metabolic profiling, as well as significantly higher levels of their biosynthesis pathways. We also found fungi with potential beneficial features for the quality of fruits. Our transcriptomic and metabolomics data provide a basis to identify potential targets to improve the pathogen resistance of the susceptible yellow cultivar. The identified fungi and affected features of the fruit of both cultivars provide important information for the control of pathogens in passion fruit industry and postharvest storage.
Arabidopsis Toxicos en Levadura 12 (ATL12): A Gene Involved in Chitin-Induced, Hormone-Related and NADPH Oxidase-Mediated Defense Responses
Authors: Kong Feng , Guo Tingwei , Ramonell Katrina M.
Published: October 2021

Plants, as sessile organisms, have evolved complex systems to respond to changes in environmental conditions. Chitin is a Pathogen-Associated-Molecular Pattern (PAMP) that exists in the fungal cell walls, and can be recognized by plants and induce plant pattern-triggered immunity (PTI). Our previous studies showed that Arabidopsis Toxicos en Levadura 12 (ATL12) is highly induced in response to fungal infection and chitin treatment. We used the model organism Arabidopsis thaliana to characterize ATL12 and explore its role in fungal defense. Histochemical staining showed that pATL12-GUS was continually expressed in roots, leaves, stems, and flowers. Subcellular co-localization of the ATL12-GFP fusion protein with the plasma membrane-mcherry marker showed that ATL12 localizes to the plasma membrane. Mutants of atl12 are more susceptible to Golovinomyces cichoracearum infection, while overexpression of ATL12 increased plant resistance to the fungus. ATL12 is highly induced by chitin after two hours of treatment and ATL12 may act downstream of MAPK cascades. Additionally, 3,3′-diaminobenzidine (DAB) staining indicated that atl12 mutants generate less reactive oxygen species compared to wild-type Col-0 plants and RT-PCR indicated that ATL12-regulated ROS production may be linked to the expression of respiratory burst oxidase homolog protein D/F (AtRBOHD/F). Furthermore, we present evidence that ATL12 expression is upregulated after treatment with both salicylic acid and jasmonic acid. Taken together, these results suggest a role for ATL12 in crosstalk between hormonal, chitin-induced, and NADPH oxidase-mediated defense responses in Arabidopsis.
Perturbations in the Heme and Siroheme Biosynthesis Pathways Causing Accumulation of Fluorescent Free Base Porphyrins and Auxotrophy in Ogataea Yeasts
Authors: Karginov Azamat V. , Alexandrov Alexander I. , Kushnirov Vitaly V. , Agaphonov Michael O.
Published: October 2021

The biosynthesis of cyclic tetrapyrrol chromophores such as heme, siroheme, and chlorophyll involves the formation of fluorescent porphyrin precursors or compounds, which become fluorescent after oxidation. To identify Ogataea polymorpha mutations affecting the final steps of heme or siroheme biosynthesis, we performed a search for clones with fluorescence characteristic of free base porphyrins. One of the obtained mutants was defective in the gene encoding a homologue of Saccharomyces cerevisiae Met8 responsible for the last two steps of siroheme synthesis. Same as the originally obtained mutation, the targeted inactivation of this gene in O. polymorpha and O. parapolymorpha led to increased porphyrin fluorescence and methionine auxotrophy. These features allow the easy isolation of Met8-defective mutants and can potentially be used to construct auxotrophic strains in various yeast species. Besides MET8, this approach also identified the HEM3 gene encoding porphobilinogen deaminase, whose increased dosage led to free base porphyrin accumulation.
Multi-Resolution Image Segmentation Based on a Cascaded U-ADenseNet for the Liver and Tumors
Authors: Zhu Yan , Yu Aihong , Rong Huan , Wang Dongqing , Song Yuqing , Liu Zhe , Sheng Victor S.
Published: October 2021

The liver is an irreplaceable organ in the human body, maintaining life activities and metabolism. Malignant tumors of the liver have a high mortality rate at present. Computer-aided segmentation of the liver and tumors has significant effects on clinical diagnosis and treatment. There are still many challenges in the segmentation of the liver and liver tumors simultaneously, such as, on the one hand, that convolutional kernels with fixed geometric structures do not match complex, irregularly shaped targets; on the other, pooling during convolution results in a loss of spatial contextual information of images. In this work, we designed a cascaded U-ADenseNet with coarse-to-fine processing for addressing the above issues of fully automatic segmentation. This work contributes multi-resolution input images and multi-layered channel attention combined with atrous spatial pyramid pooling densely connected in the fine segmentation. The proposed model was evaluated by a public dataset of the Liver Tumor Segmentation Challenge (LiTS). Our approach attained competitive liver and tumor segmentation scores that exceeded other methods across a wide range of metrics.
Hydroxyurea Induces Bone Marrow Mesenchymal Stromal Cells Senescence and Modifies Cell Functionality In Vitro
Authors: Kapor Sunčica , Vukotić Milica , Subotički Tijana , Đikić Dragoslava , Mitrović Ajtić Olivera , Radojković Milica , Čokić Vladan P. , Santibanez Juan F.
Published: October 2021

Hydroxyurea (HU) is an antineoplastic agent that functions as an antimetabolite compound by inhibiting the ribonucleotide reductase. HU acts mainly as a cytostatic drug that through DNA replication stress may trigger a premature senescence-like cell phenotype, though its influence on bone marrow-derived mesenchymal stem/stromal cell (BMMSC) functions has not elucidated yet. Our results indicate that HU inhibits the growth of human BMMSC alongside senescence-like changes in both morphology and replicative potential, provokes cell cycle arrest at the S phase without affecting cellular viability and induces the expression of senescence-associated β-galactosidase and p16INK4. Moreover, HU-induced senescent BMMSC, although they did not change MSC markers expression, exhibited reduced capacity osteogenic and adipogenic differentiation. Conversely, HU treatment increased immunoregulatory functions of BMMSC compared with untreated cells and determined by T-cell proliferation. Interestingly, HU did not influence the capacity of BMMSC to induce monocytic myeloid-derived suppressor cells. Thus, these results suggest that HU improves the BMMSC functions on the T-cell inhibition and preserves their interaction with myeloid cell compartment. Mechanistically, BMMSC under HU treatment displayed a downregulation of mTOR and p38 MAPK signaling that may explain the reduced cell differentiation and increased immunomodulation activities. Together, the results obtained in this investigation suggest that HU by inducing senescence-like phenotype of BMMSC influences their cellular differentiation and immunoregulatory functions.
Questioning the Assumptions, Sustainability and Ethics of Endless Economic Growth
Authors: Washington Haydn
Published: October 2021

This article questions the assumptions, sustainability and ethics of endless economic growth on the basis of environmental science, ecological economics and ecological ethics. It considers the impossibility and unsustainability of endless physical growth on a finite planet. It considers the indicators of environmental degradation (all increasing) and argues that society’s addiction to endless growth is irresponsible. It discusses the key problem of denial, and how this blocks us from finding workable solutions. It discusses how in theory GDP could continue to grow modestly in the future if we adopted a steady-state economy where growth was not caused by an expanding population or resource use. However, this model is currently unpopular, with many advocating the green and circular economies that are partial solutions, and which justify ongoing growth through a fantasy of absolute decoupling. I discuss the need for society to change its anthropocentric worldview to one of ecocentrism. I then question whether the UN Sustainable Development Goals are actually ecologically sustainable. I discuss how, when we ignore the problems of an endlessly growing economy, we create significant risk to society. Rather than a focus only on ‘sustainable economic growth’, I suggest it is time to focus centrally on an ecologically sustainable economy and future.
Assessing Institutional Dynamics of Governance Compliance in Emerging Markets: The GCC Real Estate Sector
Authors: Pillai Rekha , Al-Malkawi Husam-Aldin N. , Bhatti M. Ishaq
Published: October 2021

The real estate sector has emerged as the bedrock of the Gulf Cooperation Council (GCC) economies, and it has remained resilient despite the various unprecedented micro- and macro-economic shocks devouring the world’s economies. However, wavering investor attitudes and minimal exposure to real estate investment vehicles, coupled with weak regulatory frameworks, have led to dramatic downturns in the sector. Transparency about what is happening in real estate is imperative if the success of high-profile initiatives is to continue and much depends on good corporate governance (CG) in the sector. Using the most recent data from 2019, the current study applies the CG Index (CGI) and CG Deviation Index (CGDI) constructs to the real estate (RE) sector in the GCC in an effort to develop vital indicators for future RE investment decisions in the GCC region. The results indicate that the highest CG adherence levels are being achieved in Dubai, followed by Abu Dhabi and Saudi Arabia. The authors attribute these countries’ success in CG adherence to the entrepreneurial identity of them RE firms as well as to their governance capacity, their socio-cognitive capability, and the level of regulatory enforcement within the context of their dominant governance logic. It should be noted that there are variations in adherence levels throughout each region. The results also agree with prior literature that a higher CGS leads to a lower CGD score, and vice versa. At this point, encouraging more real estate investment trust (REIT) formations in the GCC could ensure value propositions, such as liquidity, to both investors and RE companies as well as solid governance fundamentals. This is strongly recommended for increasing the RE presence and its contribution to the GDP of each country.
Diagnostic Efficacy of Voxel-Mirrored Homotopic Connectivity in Vascular Dementia as Compared to Alzheimer’s Related Neurodegenerative Diseases—A Resting State fMRI Study
Authors: Cheung Eva Y. W. , Shea Y. F. , Chiu Patrick K. C. , Kwan Joseph S. K. , Mak Henry K. F.
Published: October 2021

Previous studies have demonstrated that functional connectivity (FC) of different brain regions in resting state function MRI were abnormal in patients suffering from mild cognitive impairment (MCI) and Alzheimer’s disease (AD) when comparing to healthy controls (HC) using seed based, independent component analysis (ICA) or small world network techniques. A new technique called voxel-mirrored homotopic connectivity (VMHC) was used in the current study to evaluate the value of interhemispheric functional connectivity (IFC) as a diagnostic tool to differentiate vascular dementia (VD) from other Alzheimer’s related neurodegenerative diseases. Eighty-three participants were recruited from the university hospital memory clinic. A multidisciplinary panel formed by a neuroradiologist and two geriatricians classified the participants into VD (13), AD (16), MCI (29), and HC (25) based on clinical history, Montreal Cognitive Assessment Hong Kong version (HK‑MoCA) neuropsychological score, structural MRI, MR perfusion, and 18-F Flutametamol (amyloid) PET-CT findings of individual subjects. We adopted the calculation method used by Kelly et al. (2011) and Zuo et al. (2010) in obtaining VMHC maps. Specific patterns of VMHC maps were obtained for VD, AD, and MCI to HC comparison. VD showed significant reduction in VMHC in frontal orbital gyrus and gyrus rectus. Increased VMHC was observed in default mode network (DMN), executive control network (ECN), and the remaining salient network (SN) regions. AD showed a reduction of IFC in all DMN, ECN, and SN regions; whereas MCI showed VMHC reduction in vSN, and increased VMHC in DMN and ECN. When combining VMHC values of relevant brain regions, the accuracy was improved to 87%, 92%, and 83% for VD, AD, and MCI from HC, respectively, in receiver operating characteristic (ROC) analysis. Through studying the VMHC maps and using VMHC values in relevant brain regions, VMHC can be considered as a reliable diagnostic tool for VD, AD, and MCI from HC.
Psoriasis Therapy and Skin Cancer: A Review
Authors: Butrón-Bris Beatriz , Daudén Esteban , Rodríguez-Jiménez Pedro
Published: October 2021

Introduction: psoriasis is a chronic immune-mediated disease that is associated with several comorbidities, including an increased risk of malignancies, particularly skin cancer. A large number of studies have investigated whether psoriasis itself, psoriasis-associated comorbidities, or psoriasis treatment could lead to an increased risk of neoplasms. Methods: we reviewed the literature using the most important databases (PubMed, MEDLINE, ETHERIA). All articles pertaining to skin cancer associated with psoriasis disease and psoriasis therapy were included. In this review, we also discuss some of the potential underlying mechanisms for these associations, particularly regarding the multiple psoriasis therapies currently available, and their possible implications in higher incidences of skin cancer in these patients. Conclusion: evidence suggests that these patients might have a higher risk of cutaneous malignancies, especially for NMSC, compared with psoriasis-free patients. The reasons for this increased risk remain to be determined. However, high dose PUVA therapy, the immunosuppressive treatments used, and the comorbidities and habits frequently described in these patients seem to play a role in the pathogenesis of these tumors. Because of these facts, periodic screening for skin cancer is recommended in this population.
Clinical Characteristics of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes
Authors: Fan Hueng-Chuen , Lee Hsiu-Fen , Yue Chen-Tang , Chi Ching-Shiang
Published: October 2021

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, a maternally inherited mitochondrial disorder, is characterized by its genetic, biochemical and clinical complexity. The most common mutation associated with MELAS syndrome is the mtDNA A3243G mutation in the MT-TL1 gene encoding the mitochondrial tRNA-leu(UUR), which results in impaired mitochondrial translation and protein synthesis involving the mitochondrial electron transport chain complex subunits, leading to impaired mitochondrial energy production. Angiopathy, either alone or in combination with nitric oxide (NO) deficiency, further contributes to multi-organ involvement in MELAS syndrome. Management for MELAS syndrome is amostly symptomatic multidisciplinary approach. In this article, we review the clinical presentations, pathogenic mechanisms and options for management of MELAS syndrome.
Thermogravimetric Experiment of Urea at Constant Temperatures
Authors: Zhu Neng , Qian Feng , Xu Xiaowei , Wang Mingda , Teng Qi
Published: October 2021

There are still many unsolved mysteries in the thermal decomposition process of urea. This paper studied the thermal decomposition process of urea at constant temperatures by the thermal gravimetric–mass spectrometry analysis method. The results show that there are three obvious stages of mass loss during the thermal decomposition process of urea, which is closely related to the temperature. When the temperature was below 160 °C, urea decomposition almost did not occur, and molten urea evaporated slowly. When the temperature was between 180 and 200 °C, the content of biuret, one of the by-products in the thermal decomposition of urea, reached a maximum. When the temperature was higher than 200 °C, the first stage of mass loss was completed quickly, and urea and biuret rapidly broke down. When the temperature was about 240 °C, there were rarely urea and biuret in residual substance; however, the content of cyanuric acid was still rising. When the temperature was higher than 280°C, there was a second stage of mass loss. In the second stage of mass loss, when the temperature was higher than 330 °C, mass decreased rapidly, which was mainly due to the decomposition of cyanuric acid. When the temperature was higher than 380 °C, the third stage of mass loss occurred. However, when the temperature was higher than 400 °C, and after continuous heating was applied for a sufficiently long time, the residual mass was reduced to almost zero eventually.
Mechanical Properties and Constitutive Model Applied to the High-Speed Impact of Aluminum Foam That Considers Its Meso-Structural Parameters
Authors: Guo Qian , Li Wenbin , Yao Wenjin , Wang Xiaoming , Huang Changqiang
Published: October 2021

In this work, quasistatic mechanical compression experiments were used to study the stress–strain relationship of aluminum foam, and the mechanism of the compressive deformation of aluminum foam under quasistatic compression conditions is discussed based on the experimental observations. Since the interactions among cells of the aluminum foam and differences in compressive strength among cells substantially impacted the mechanical properties of the material, the cellular structural parameters, namely the cell size and cell wall thickness, were defined. Along with the mechanism of deformation of a single cell, the influence of structural parameters on the micro failure mechanism and the stress–strain relationship of the aluminum foam material was analyzed. In combination with the factors influencing the mechanical properties of the aluminum foam, a mechanical constitutive model of aluminum foam suitable for multi-density and multi-impact environments that considers cellular structure density was established to predict the complete stress–strain relationship of aluminum foam under a high strain rate. The coupling function of strain rate and temperature in the original model was verified and the parameters were determined by the compression experiments under different strain rates and different temperatures.
Synchronization of a Network Composed of Stochastic Hindmarsh–Rose Neurons
Authors: Rehák Branislav , Lynnyk Volodymyr
Published: October 2021

An algorithm for synchronization of a network composed of interconnected Hindmarsh–Rose neurons is presented. Delays are present in the interconnections of the neurons. Noise is added to the controlled input of the neurons. The synchronization algorithm is designed using convex optimization and is formulated by means of linear matrix inequalities via the stochastic version of the Razumikhin functional. The recovery and the adaptation variables are also synchronized; this is demonstrated with the help of the minimum-phase property of the Hindmarsh–Rose neuron. The results are illustrated by an example.
Dynamic Influence Ranking Algorithm Based on Musicians’ Social and Personal Information Network
Authors: Liu Yiming , Wang Longxin , Jia Yunsong , Li Ziwen , Gao Hongju
Published: October 2021

Social influence analysis is a very popular research direction. This article analyzes the social network of musicians and the many influencing factors when musicians create music to rank the influence of musicians. In order to achieve the practical purpose of the model making accurate predictions in the broad music market, the algorithm adopts a macromodel and considers the social network topology network. The article adds the time decay function and the weight of genre influence to the traditional PageRank algorithm, and thus, the MRGT (Musician Ranking based on Genre and Time) algorithm appears. Considering the timeliness of social networks and the continuous development of music, we realized the importance of evolving MRGT into a dynamic social network. Therefore, we adopted audio data analysis technology and used Gaussian distance to classify and study the evolution of music properties at different times and different genres and finally formed the dynamic influence ranking algorithm based on musicians’ social and personal information networks. As a macromodel heuristic algorithm, our model is explanatory, can handle batch data and can avoid unfavorable factors, so as to provide fast speed and improved accuracy. The network can obtain an era indicator DMI (Dynamic Music Influence) that measures the degree of music revolution. DMI is the indicator we provide for music companies to invest in musicians.
On Graded S-Primary Ideals
Authors: Alshehry Azzh Saad
Published: October 2021

Let R be a commutative graded ring with unity, S be a multiplicative subset of homogeneous elements of R and P be a graded ideal of R such that P⋂S=∅. In this article, we introduce the concept of graded S-primary ideals which is a generalization of graded primary ideals. We say that P is a graded S-primary ideal of R if there exists s∈S such that for all x,y∈h(R), if xy∈P, then sx∈P or sy∈Grad(P) (the graded radical of P). We investigate some basic properties of graded S-primary ideals.
Radiological and Physiological Predictors of IPF Mortality
Authors: Kishaba Tomoo , Maeda Akiko , Yamazato Shoshin , Nabeya Daijiro , Yamashiro Shin , Nagano Hiroaki
Published: October 2021

Background and Objectives: Idiopathic pulmonary fibrosis (IPF) has a variable clinical course, which ranges from being asymptomatic to progressive respiratory failure. The purpose of this study was to evaluate the novel clinical parameters of IPF patients who receive an anti-fibrotic agent. Materials and Methods: From January 2011 to January 2021, we identified 39 IPF patients at Okinawa Chubu Hospital. Clinical information was obtained, such as laboratory data, pulmonary function test (PFT) results, and chest images, including of soft tissue thickness and the high-resolution computed tomography (HRCT) pattern at diagnosis. Results: The mean age was 72.9 ± 7.0 (53–85); 27 patients were men and 12 were women. The mean body mass index was 25.1 ± 3.9 (17.3–35). Twenty-four were active smokers and the median number of packs per year was 20. Regarding laboratory findings, mean white blood cell (WBC), lactate dehydrogenase (LDH), and Krebs Von den Lungen-6 (KL-6) values were 7816 ± 1859, 248 ± 47, and 1615 ± 1503, respectively. In PFT, the mean percent predicted FVC, percent predicted total lung capacity, percent predicted functional residual capacity (FRC), and percent predicted diffusion capacity of the lung for carbon monoxide (DLco) were 66.8 ± 14.9%, 71.8 ± 13.7%, 65 ± 39.6%, and 64.6 ± 27.9%, respectively. In chest radiological findings, soft tissue thickness at the right 9th rib was 26.4 ± 8.8 mm. Regarding chest HRCT patterns, 15 showed the definite usual interstitial pneumonia (UIP) pattern, 16 showed the probable UIP pattern, and eight showed the indeterminate for UIP pattern. In the treatment, 24 patients received pirfenidone and 15 patients took nintedanib. The mean observation period was 38.6 ± 30.6 months and 24 patients died. The median survival time was 32.4 months (0.9–142.5). Multivariate analysis adjusted for age showed that both soft tissue thickness [Hazard ratio (HR): 0.912, 95% confidence interval (CI): 0.859–0.979, p-value: 0.009] and percent FRC [HR: 0.980, 95% CI: 0.967–0.992, p-value: 0.002] were robust predictors of IPF mortality. Conclusions: In IPF patients treated with anti-fibrotic agents, both soft tissue thickness at the right 9th rib shown on the chest radiograph and %FRC can be novel predictors of IPF mortality.
Comparison of Perioperative Outcomes Using the da Vinci S, Si, X, and Xi Robotic Platforms for BABA Robotic Thyroidectomy
Authors: Shin Hye Rim , Lee Keunchul , Yu Hyeong Won , Kim Su-jin , Chai Young Jun , Choi June Young , Lee Kyu Eun
Published: October 2021

Background and Objectives: Robotic thyroidectomy via the bilateral axillo-breast approach (BABA), first introduced in Korea in 2008, has become a standard method of thyroid removal worldwide. The introduction of robotic surgical systems has enabled more patients to benefit from BABA robotic thyroidectomy, with good postoperative and excellent cosmetic results. To date, no studies have compared the benefits of the four currently available da Vinci robotic systems (S, Si, X, and Xi) for BABA robotic thyroidectomy. To determine the da Vinci model most suitable for BABA robotic thyroidectomy, the present study compared the perioperative outcomes in patients who underwent BABA robotic thyroidectomy using the four da Vinci models. Materials and Methods: This retrospective study evaluated outcomes in patients (n = 750) who underwent BABA robotic thyroidectomy using the four da Vinci systems from 2013 to 2019. The clinicopathologic data, including operation time, were compared. Substudy A compared the da Vinci models S and Si from 2013 to 2017, and substudy B compared models Si, X, and Xi from 2018 to 2019. Results: Substudy A, comparing the da Vinci S and Si systems, found no statistically significant differences between the two groups, whereas substudy B found that operation time was shorter in patients who underwent BABA robotic thyroidectomy with the da Vinci Xi system than with the Si and X systems. Conclusions: The da Vinci model Xi system can benefit patients undergoing BABA robotic thyroidectomy by shortening the operation time.