bluuebunny/crossref_metadata_2025 huggingface dataset:
ÓBITOS DE MULHERES EM IDADE FÉRTIL RELACIONADAS A GRAVIDEZ, PARTO E/OU PUERPÉRIO NO ESTADO DO PARANÁ ENTRE 2016 E 2020
Authors: Gaspar Maria Clara Furlan , Rymsza Taciana
Published: October 2023

Apesar dos muitos esforços a nível estadual, municipal e nacional ao longo dos últimos, um consenso nacional sobre a melhor forma de identificar, rever e prevenir as mortes maternas continua a ser um desafio. O objetivo do presente estudo foi fazer um levantamento epidemiológico dos óbitos relacionados a gravidez, parto e puerpério notificados no estado do Paraná. Estudo ecológico, de série temporal, de abordagem quantitativa e de natureza descritiva com base no DATASUS entre 2016 e 2020. Foram coletadas as variáveis: etnia, faixa etária, local do óbito, nível de escolaridade, macrorregião do estado e causa segundo CID (O00 – O99). Entre os anos de 2016 e 2020, foram registradas 378 mortes, sendo 2020 o ano com maior número de casos (84) e 2017 o menor (57), a variação temporal no estado foi de +1,2% com uma taxa de mortalidade de 3,67 óbitos por 100 mil habitantes. A idade das vítimas variou de 10 a 49 anos. Sendo mais prevalente entre 30 e 39 (40,8%) seguido de 20 a 29 (40,4%). Com relação à etnia, 64,8% dos óbitos ocorreu em mulheres brancas, seguido de pardas (22,2%). A doença agravada no parto foi a causa mais prevalente (20,25%) dos óbitos maternos, seguida por mortes após o puerpério (13,5%), em terceiro (8,2%) esteve a hipertensão gestacional com proteinúria significativa.
TIPOS DE ESTRUTURAS PARA FUNDAÇÕES DE PEQUENO E MÉDIO PORTE: REVISÃO DE LITERATURA
Authors: Ortega Weigle Ventura , Pedreiro Marcelo Rodrigues de Matos
Published: October 2023

A engenharia de fundações, trata-se de uma área de conhecimento na engenharia civil, em que interagem, estudos, experiências e precauções, decorrentes de inúmeros problemas que podem apresentar. Essas inúmeras manifestações patológicas, decorrentes de problemas de fundações, costumam ter origem em um ou mais processos que acontecem desde a fase do projeto até o pós-obra. Sempre foram objetos de inúmeros estudos e preocupações decorrentes da complexidade das suas características. Sendo assim, a previsão das cargas admissíveis em um elemento da fundação e de sua profundidade ideal, devem ser devidamente estabelecidas pelo engenheiro civil, com bases nas normas brasileiras, pois, envolve a segurança dos usuários da edificação. Partindo dessa importância, o presente trabalho teve como objetivo, realizar uma revisão de literatura (pesquisa bibliográfica), com base em dados acadêmicos. Após a coleta destes, discorreu-se sobre o conceito e a classificação das fundações, a classificação dos recalques e as possíveis soluções para os recalques em fundações. Com a realização do mesmo, foi possível concluir que são diversas as causas de problemas em fundações, é que para cada obra deve ser realizadas análises individuais com base nos solos e nas cargas que podem causar movimentações, realizando o monitoramento dos recalques durante toda a vida útil da obra, destacando sempre a importância do profissional da área para assegurar que essas patologias sejam devidamente corrigidas.
JOGO EDUCACIONAL SPEED RACER NO ENSINO DE MATEMÁTICA PARA ALUNOS DO ENSINO FUNDAMENTAL I EM LÁBREA-AM: UMA ANÁLISE NO ESTÁGIO SUPERVISIONADO
Authors: Rodrigues Borrosa Matias , Rodrigues Eunício Gomes , Silva Marinilson Ferreira da , Silva Rosenilde Soares da , Libório Filho João da Mata , Trindade Genarde Macedo
Published: October 2023

Neste artigo, abordamos o uso de jogos educacionais no ensino de matemática para alunos do Ensino Fundamental I, mais especificamente do 5º ano. O objetivo é discutir a implementação do jogo Speed Racer como parte de um plano de ação durante o estágio supervisionado para melhorar o aprendizado matemático. Os resultados e discussões evidenciam os benefícios da gamificação na potencialização do ensino de matemática e seu impacto positivo nos alunos. Este trabalho foi realizado durante o estágio supervisionado na Escola Estadual Santo Agostinho.
O USO INDISCRIMINADO DE ANTIBIÓTICOS NA RESISTÊNCIA BACTERIANA INFANTIL
Authors: Colouna Amanda Alves Teodoro , Fernandes Cíntia Nathália Henrique , Lima Vaneza de França , Damascena Hylane Luiz
Published: October 2023

O objetivo desse artigo é discutir a resistência bacteriana em crianças, compreendendo, inicialmente, o que constitui a resistência a antibióticos e os fatores que contribuem para esse fenômeno. O uso indiscriminado de antibióticos, a não adesão ao período de tratamento e a disponibilidade de antibióticos sem prescrição médica são aspectos relevantes a serem considerados. Crianças frequentemente recebem medicamentos para tratar dor, febre ou infecções, tanto em ambientes hospitalares como em casa. Nesse contexto, é fundamental a presença de profissionais qualificados e a conscientização dos pais ou responsáveis quanto à automedicação em crianças.A metodologia utilizada baseou-se em pesquisas realizadas nas seguintes fontes de dados: SciELO, Biblioteca Virtual em Saúde (BVS), PubMed, Organização Mundial da Saúde (OMS), Agência Nacional de Vigilância Sanitária (ANVISA) e livros de referência.
A metodologia utilizada baseou-se em pesquisas realizadas nas seguintes fontes de dados: SciELO, Biblioteca Virtual em Saúde (BVS), PubMed, Organização Mundial da Saúde (OMS), Agência Nacional de Vigilância Sanitária (ANVISA) e livros de referência.
Assessment of pluri-annual and decadal changes in terrestrial water storage predicted by global hydrological models in comparison with the GRACE satellite gravity mission
Authors: Pfeffer Julia , Cazenave Anny , Blazquez Alejandro , Decharme Bertrand , Munier Simon , Barnoud Anne
Published: October 2023

Abstract. The GRACE (Gravity Recovery And Climate Experiment) satellite gravity mission enables global monitoring of the mass transport within the Earth's system, leading to unprecedented advances in our understanding of the global water cycle in a changing climate. This study focuses on the quantification of changes in terrestrial water storage with respect to the temporal average based on an ensemble of GRACE solutions and two global hydrological models. Significant changes in terrestrial water storage are detected at pluri-annual and decadal timescales in GRACE satellite gravity data that are generally underestimated by global hydrological models though consistent with precipitation. The largest differences (more than 20 cm in equivalent water height) are observed in South America (Amazon, São Francisco and Paraná River basins) and tropical Africa (Congo, Zambezi and Okavango River basins). Smaller but significant (a few centimetres) differences are observed worldwide. While the origin of such differences is unknown, part of it is likely to be climate-related and at least partially due to inaccurate predictions of hydrological models. Pluri-annual to decadal changes in the terrestrial water cycle may indeed be overlooked in global hydrological models due to inaccurate meteorological forcing (e.g. precipitation), unresolved groundwater processes, anthropogenic influences, changing vegetation cover and limited calibration/validation datasets. Significant differences between GRACE satellite measurements and hydrological model predictions have been identified, quantified and characterised in the present study. Efforts must be made to better understand the gap between methods at both pluri-annual and decadal timescales, which challenges the use of global hydrological models for the prediction of the evolution of water resources in changing climate conditions.
EVALUATION OF MEAT PRODUCTIVITY OF PUREBRED STALLION CAMELS OF THE KAZAKH BACTRIAN BREED (Camelus Bactrianus)
Authors:   Limited Liability Company ", Baimukanov D.A. ,   Scientific and Production Center of Animal Husbandry and Veterinary Medicine",   , Astanacity, Kazakhstan, Bisеmbayev A.T. ,   Limited Liability Company "Scientific and Production Center of Animal Husbandry and Veterinary Medicine", Astanacity, Kazakhstan, Bekenov D.M. ,   Limited Liability Company "Baiserke-Agro Educational Research and Production Center", Almaty region, Kazakhstan, Kargaeva M.T. ,   Limited Liability Company "Baiserke-Agro Educational Research and Production Center", Almaty region, Kazakhstan
Published: October 2023

Цель работы – проведение сравнительной оценки мясной продуктивности 18 месячных верблюдов-самцов (жеребчиков) породы казахский бактриан молочного, молочно-мясного и мясо-шерстного направления продуктивности. В трехдневном возрасте у верблюжат – самцов (жеребчиков) казахского бактриана живая масса составляет 31,8-34,9 кг. До шестимесячного возраста интенсивно развиваются верблюжата от верблюдоматок молочного направления продуктивности (135,9 кг), в сравнении со сверстниками от верблюдоматок мясо – молочного (124,4 кг) и мясо – шерстного (127,6 кг) направления продуктивности. Данна динамика сохраняется до 9 месячного возраста, то есть в молочный период. В 12 месячном возрасте живая масса составляет у жеребчиков от верблюдоматок молочного направления продуктивности 185,7 кг, мясо – молочного 219,1 кг (p <0,01) мясо – шерстного 195,2 кг (p <0,05). В 15 и 18 месячном возрасте живая масса составила соответственно: 220,1-264,6-251,5 кг и 311,5 – 333,6 – 352,8 кг (p <0,01). До шестимесячного возраста коэффициент роста составил у верблюжат от верблюдоматок: молочного направления продуктивности 3,27; мясо – молочного 2,56; мясо – шерстного 2,89. От трехдневного возраста до отъема коэффициент роста составил у верблюжат от верблюдоматок: молочного направления продуктивности 4,00; мясо – молочного 3,23; мясо – шерстного 3,61. От рождения до 18 месячного возраста коэффициент роста живой массы составил соответственно 8,80-8,56-9,76. На естественных пастбищах средний суточный прирост у жеребчиков верблюдов породы казахский бактриан составляет: от рождения до шестимесячного возраста 497,22 – 578,33 г; от рождения до 9 месячного возраста 418,15 – 44,44 г; от рождения до 18 месячного возраста 518,00 – 592,6 г. Убойный выход составляет у 18 месячных жеребчиков от верблюдоматок молочного направления продуктивности 53,30%, мясо -молочного 56,05% и мясо – шерстного 56,28%. В проведенных исследованиях туши 18 месячных жеребчиков казахского бактриана содержат мякоти 75 - 77%, 20,5 – 23,0% кости и хрящи, 2,0-3,1% сухожилия. Коэффициент мясности составляет 3,26 -3,76
Debt Swap Funding Nexus Education Attainment in the Presence of Per Capita Income in Debt Burdened Economies: An Empirical Analysis Using Two Step SYS-GMM
Authors: Ahmad Umar Suffian , Safdar Sadia , Azam Muhammad
Published: October 2023

Debt swap funding is one of the important catalysts for education attainment in debt-burdened economies. It enhances the education status by providing extra fiscal space for the government to invest resources for quality education, increasing capital inflow, and reducing the debt burden in the recipient countries. The main purpose of the study is to investigate the impact of debt swap funding on education attainment in debt-burdened economies for the period 2003-2021. The relationship between debt swap funding and education attainment is analyzed in the presence of per capita income of the respective countries by using the advanced methodology Two Step System GMM. Other variables, which are the main determinants of debt swap funding, like IMF structural adjustment program and debt service, are used as control variables. Education attainment is also dependent on per capita income included in the model, along with growth parameters of new growth theory (technological growth, population growth, and depreciation rate), which are part of the control variables. The results of the study show a positive and statistically significant relation between debt swap funding and education attainment in debt-burdened economies in the presence of per capita income. Policy recommendations are proposed in light of the results obtained regarding the debt swap funding nexus education attainment.
UPAYA PENINGKATAN KUALITAS PENDIDIKAN DENGAN PENERAPAN KEDISIPLINAN GURU DI SD MUHAMMADIYAH 9 “PANGLIMA SUDIRMAN” MALANG
Authors: Agustin Ayu , Ashari Muhammad Hasyim
Published: October 2023

As an effort to improve the quality of education is the discipline of teachers. Increasing teacher discipline in the teaching and learning process is expected to improve the quality and quality of education in order to give birth to the next generation who are superior and have good morals. This community service activity was carried out at SD Muhammadiyah 9 "Panglima Sudirman" Malang with the following stages: observing and mapping disciplinary actions, conducting studies on alternative solutions in policy formulation, awareness of the importance of discipline for teachers, and consultation or assistance. The implementation of this activity went well with the result that the teacher carries out his duties and obligations with full sincerity, awareness, patience and a sense of responsibility, because he realizes that discipline in the world of education is important and must start from the teacher as a teacher, to be able to create superior human resources and beneficial to the nation, state and society. The discipline of teachers at SD Muhammadiyah 9 "Panglima Sudirman" Malang is quite good, although there are still some teachers who lack discipline in complying with the rules set by the school. Socialization and coaching continues to be pursued by the school in order to reduce cases of disciplinary violations, with the aim of creating a good educational environment and being a good role model for students at SD Muhammadiyah 9 "Panglima Sudirman" Malang. Keywords: discipline, education, teacher, quality, qualified.
MEMBANGUN PERSONAL BRANDING DAN KEMAMPUAN PUBLIC SPEAKING UNTUK PENGEMBANGAN KARIR MASA DEPAN PEMUDA
Authors: Syaifudin Ahmad Anif , Narto Sutin
Published: October 2023

Indonesia has a demographic bonus in 2045. This opportunity is projected to be a golden period where there are many opportunities, potential, and opportunities for people in their careers. To welcome the demographic bonus, planning training that can develop the community, namely public speaking and personal branding skills is necessary. Personal branding and public speaking are personal competencies that need to be developed in facing the challenges of an increasingly competitive world of work. This activity aims to improve partners' skills in presentation, speech, MC, and communicating effectively. While the skills of building a self-image (personal branding) are a way for partners to market themselves to be recognized by others. The methods used include 1) analysis of partner needs as a benchmark for ability and material limits, 2) training and mentoring of partners which is the core of the program, where partners are provided with material on public speaking and personal branding techniques. The results of this service show that partners are able to plan how to brand themselves with self-promotion. In addition, partners are more confident in speaking in public. This can be seen from the enthusiasm of the partners when practicing as master of ceremony and speakers on stage.
IMPLEMENTASI PEMBELAJARAN HAPPY LEARNING DAN KARTU SETORAN TPQ DI MASJID DESA NGARGOSARI BAGIAN UTARA UTARA
Authors: Argayudha Rois Heldan
Published: October 2023

Research on the implementation of TPQ deposit cards in the northem part of the Ngargosari Village mosque. The application of use of the TPQ deposit card is used to determine the capacity of the ability of TPQ students in terms of reading the Al-Qur’an. This is because researchers found obstacles in TPQ learning activities, where the absence of a TPQ deposit card made it difficult for TPQ teachers to determine their level of understanding and skills in reading the Al-Qur’an. Meanwhile, so that students can easily master material related to Islamic religion, the researcher tries to use the Happy Learning method so that it can create a dynamic learning atmosphere because it was found that the early learning model was less sweet because it only focused on reading the Al-Qur’an. In explaining this research, it was carried outusing a qualitative approach. Meanwhile, the source of the data is taken from the library which tries to get from previous research and books that support and use observation and field practice.
PEMBERDAYAAN EKONOMI MASYARAKAT MELALUI PENGEMBANGAN EKONOMI REMAJA MASJID
Authors: Waluyo Waluyo , Nurohman Yulfan Arif , Qurniawati Rina Sari
Published: October 2023

People's hopes of getting a better life can be done by developing the economy. One way to develop the economy is by developing livestock businesses. Village communities who work as farmers often experience economic difficulties so solutions need to be provided to help the family economy. Mosque youth have the potential to be provided with economic development programs through goat seed waqf. Mosque youth as the next generation have greater opportunities for economic development in the future. The aim of the community service program implemented in Tempuran Village is to improve the economy through goat seed waqf. The community service program is divided into four stages. Starting from deepening the problem, focus group discussions determining material, training; and mentoring. The results of this program provide the benefit of increasing income for the community in Tempuran Village by optimizing the goat seed waqf.
Predicting vapor-liquid equilibria of CO2+HFC binary mixtures by the PR EOS combined with a group contribution model
Authors: Wu Zirui , Shi Lingfeng , Sun Rui , Tian Hua , Wang Xuan , Shu Gequn ,   Department of Thermal Science and Energy Engineering, University of Science and Technology of China, Hefei 230027, China,   State Key Laboratory of Engines, Tianjin University, Tianjin 300072, China
Published: October 2023

CO2+HFC binary mixtures have good performance and environmental friendliness and are considered good alternative working fluids in cooling and power cycle systems. The vapor-liquid phase equilibrium properties are key to the calculation of the enthalpy and entropy of mixtures, which is critical for the analysis of cooling and power cycle systems. To accurately predict the vapor-liquid equilibrium of CO2 and HFC (R23, R32, R41, R125, R134a, R143a, R152a, R161, and R227ea) binary mixtures, a group contribution model based on the excess free energy (GE) mixing rules (PR+MHV1+UNIFAC and PR+LCVM+UNIFAC) is established in this paper. The interaction parameters between groups such as -CO2, -Alkane, -CHF, and -CHF3 are obtained by the vapor-liquid phase equilibrium experiment of CO2 and HFC refrigerants, and these group parameters are critical for predicting their vapor-liquid phase equilibrium properties (the pressures and vapor phase molar fractions). The AARDp value calculated by the PR+LCVM+UNIFAC model is 5.53%, the value of AADy1 is 0.0132, and the AARDp and AADy1 values of the PR+MHV1+UNIFAC model are 7.40% and 0.0229, respectively. However, for the CO2+R32 system, the PR+MHV+UNIFAC prediction model can reproduce the experimental data with lower deviations, and the values of AARDp and AADy1 are 1.53% and 0.0045, respectively. In summary, for CO2+HFC binary mixtures, the PR+LCVM+UNIFAC group contribution model can reproduce the experimental data with lower deviations, but for individual CO2 binary mixtures (such as CO2+R32), the PR+MHV1+UNIFAC model also has unique advantages. According to the prediction results of the group contribution model, the PR+LCVM+UNIFAC model has significantly improved the calculation progress compared with the PR+MHV1+UNIFAC model used in the previous system.
Thermophysical properties of 1D materials: transient characterization down to atomic level
Authors: Karamati Amin , Xu Shen , Lin Huan , Rahbar Mahya , Wang Xinwei ,   Department of Mechanical Engineering, Iowa State University, Ames 50011, USA,   School of Mechanical and Automotive Engineering, Shanghai University of Engineering Science, Shanghai 201620, China,   School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao 266033, China
Published: October 2023

The thermophysical properties of 1D micro/nanoscale materials could differ significantly from those of their bulk counterparts due to intensive energy carrier scattering by structures. This work provides an in-depth review of cutting-edge techniques employed for transient characterization of thermophysical properties at the micro/nanoscale scale. In terms of transient excitation, step Joule heating, step laser heating, pulsed laser heating, and frequency domain amplitude-modulated laser heating are covered. For thermal probing, electrical and Raman scattering-based physical principles are used. These techniques enable the measurement of thermal conductivity, thermal diffusivity, and specific heat from the sub-mm level down to the atomic level (single-atom thickness). This review emphasizes the advantages of these techniques over steady state techniques and their physics, challenges, and potential applications, highlighting their significance in unraveling the intricate thermal transport phenomena to the atomic level of 1D materials.
The Resolution of Environmental Disputes among Traditional Fishermen in Gampong Sungai Lueng, Langsa, Aceh, Indonesia
Authors: Emia Tarigan Vita Cita , Asnawi Iqbal , Mulyadi Mahmud
Published: October 2023

Gampong Sungai Lueng (referred to in Acehnese) in Langsa is an area rich in mangrove ecosystems, which play a crucial role in maintaining environmental sustainability and supporting the livelihoods of local traditional fishermen. However, in recent years, this area has faced several environmental problems, including uncontrolled mangrove tree cutting, which poses a threat to marine ecosystems and the well-being of local fishermen. This research aims to address environmental disputes among traditional fishermen in Gampong Sungai Lueng, Langsa. The research method employed is a normative juridical approach. The research specifications are descriptive and analytical in nature. The sources and types of data encompass primary and secondary data. Data analysis is conducted qualitatively, given that the collected data are of a descriptive-analytical nature. The research findings regarding the resolution of environmental disputes among traditional fishermen in Gampong Sungai Lueng, Langsa, represent complex and significant challenges in endeavors to preserve marine ecosystem sustainability and environmental protection. The results of the initial pre-test indicate that there are participants with inadequate knowledge concerning environmental regulations, including the prohibition of coastal tree cutting or mangroves, as well as related criminal issues. However, the majority of participants possess a solid understanding of essential aspects, such as these prohibitions, dispute resolution through either mediation or litigation, and the legal consequences of engaging in vigilantism.

Keywords: dispute resolution, mangroves, and traditional fishermen
Fuzzy Dot Completely Closed BH-Ideal of BH-Algebra
Authors: Abdulhussein Mohsin Shaalan , Mohammed Maryam Abbas , Kareem Noor Riyadh
Published: October 2023

This article introduces the ideas of fuzzy dots in BH-algebras and fuzzy dots ideals in BH-algebras and discusses some of the research's findings.

Keywords: Fuzzy dots, BH-algebras, BCK-algebras
A Review on the Scope of Homoeopathic Medicines in Managing Adjustment Disorder
Authors: Chandrasekaran Lavanya , U.K. Girish Navada , Ravikumar Diana
Published: October 2023

The ability to adjust is an important feature of every human to lead a happy and peaceful life. Though adjustment disorder is a very common phenomenon, its diagnosis is quite difficult. Thus, making it a rare clinical picture. Since it is difficult to diagnose, it warrants more study on the matter and in-depth research into the different effective and innovative treatment modalities available. Homoeopathy is a system of medicine which deals with understanding the patient as a whole and aims to treat the cause of the disease. Likewise, in adjustment disorder, Homoeopathic medicine focuses on treating the cause of disease, depending on the case.

Keywords: Homoeopathy, Adjustment disorder, Psychiatry, Paediatrics, Psychology, Depression, Anxiety
DATA-DRIVEN IDENTIFICATION OF HYPERELASTIC MODELS BY MEASURING THE STRAIN ENERGY DENSITY FIELD
Authors: Costecalde Léna , Leygue Adrien , Coret Michel , Verron Erwan
Published: October 2023

A novel method for accurately identifying the large strain elastic response of elastomeric materials is presented. The method combines the data-driven identification (DDI) algorithm with a unique heterogeneous experiment, deviating from the conventional approach of conducting multiple simple experiments. The primary objective of the method is to decouple the experimental process from the fitting technique, relying instead on a single comprehensive experiment to generate an extensive collection of stress and strain energy fields. This collection is then used in conjunction with a standard fitting technique to determine the parameters of hyperelastic models. Notably, the approach places significant emphasis on the strain energy density field as a critical factor in model identification, as it encompasses the full material response within a single scalar quantity. To demonstrate the effectiveness of the proposed approach, a proof of concept is provided using synthetic data. The results highlight the efficiency of the method and emphasize the importance of incorporating the strain energy density field for precise model identification, surpassing the reliance on stress data alone. In addition, several graphical tools are introduced to evaluate and analyze the quality of both the generated mechanical fields and the identification results. The proposed approach offers a more comprehensive representation of the material behavior and enhances the reliability and prediction capabilities of hyperelastic material models. It holds significant potential for advancing the field of solid mechanics, particularly in accurately characterizing the mechanical responses of elastomeric materials.
Application of Simplex Lattice Mixture design and desirability function in the development and Optimization of SEDDS for protein kinase inhibitor-Pazopanib Hydrochloride
Authors: Gupta Amit , Dahima Rashmi
Published: October 2023

Pazopanib Hydrochloride is a tyrosine protein kinase inhibitor molecule approved by USFDA and European agencies for the treatment of renal cell carcinoma (RCC) patients and other renal malignancies, but it has very poor aqueous solubility. Therefore, it is essential need to improve the solubility and in vitro dispersion or release characteristics. The purpose of this study was to investigate the Pazopanib hydrochloride drug solubility in various vehicles and screening of suitable solubilizers for the preparation of self-emulsifying lipid-based drug delivery systems (SE-LBDDS) of a poorly water-soluble drug (BCS class II), Pazopanib HCl by using simplex lattice mixture design. Ternaryplots wereconstructed by using oil (Labrafac WL 1349l), surfactant (Labrasol), and co-surfactant (Transcutol-P), and the concentration ranges were determined by using a simplex lattice design. The composition of pazopanib HCl SEEDS was optimized through various dependent variables (responses)such as solubility (Y1), precipitation after 15 min (Y2), and, particle size (Y3).Solubility study of pazopanib HCl in different oils, surfactants, and co-surfactants was carried out by shake flask method at 37°C. Three formulation components were chosen based on the maximum solubility results inthe oil, surfactant, and co-surfactant category and included in the experimental design. The results were analyzed by model fitting using the standard least-squares method. Pazopanib HCl were shown maximum solubility i.e. 25.64±0.24mg/g, 57.84 ±2.91mg/g and, 44.61±1.51mg/g in Labrafac WL 1349 (oil), Labrasol (surfactant) and Transcutol-P (co-surfactant) respectively. Hence these chosen formulation component's concentrations were further optimized by using a simplex lattice design (SLD). Derived mathematical polynomial equations and models were exercised to evaluate the impact of formulation input variables on the output variables (responses) using JMP software. The model p-value for both the responses i.e. solubility and particle size were found less than 0.05 hence models were significant. The results of the mathematical analysis demonstrated that the formulation components have a significant impact on the studied responses. Hence simplex lattice mixture design can be used as a powerful quality design to predict the optimized SEDDS formulation.The applicability of simplex lattice design with desirability function helped optimize a SEEDS formulation of pazopanib HCl and the selected model has made it possible to identify the impact of the critical factors to optimize the required responses.
Behavioral, Biochemical and Histopathological Evaluation of Sinapic acid for Antidepressant activity in Normal Mice and Stressed Mice
Authors: Bansal Sudha , Dhingra Dinesh
Published: October 2023

In this study, sinapic acid was evaluated for its effect on depressive behavior of normal mice and stressed mice. Swiss albino male mice were given unpredictable mild stressors for twenty-one consecutive days to produce depressive behavior. Sinapic acid (5, 10, 20 mg/kg) and fluoxetine (20 mg/kg) were given orally to mice for twenty-one days in succession. Depressive behavior was detected by tail suspension test and sucrose preference test. After behavioral testing, biochemical estimations were performed in plasma (nitrite, corticosterone) and brain (MAO-A, malondialdehyde, reduced glutathione, catalase, TNF-α). Histopathological studies on the brain were also performed. The immobility time of mice in the tail suspension test was remarkably decreased by sinapic acid (5 and 10 mg/kg). Sinapic acid restored the decreased sucrose preference in mice exposed to the stress paradigm. It also remarkably lowered concentration of plasma nitrite and corticosterone; brain malondialdehyde, monoamine oxidase- A and TNF-α; and increased the concentration of brain catalase and GSH in normal mice and also stressed mice. Histopathological studies indicated protective effect of sinapic acid against hyperchromatic nuclei in the brain. Thus, sinapic acid produced remarkable antidepressant effect in normal mice and also stressed mice. The possible mechanisms for the observed antidepressant effect of sinapic acid might be through inhibition of brain MAO-A, amelioration of neuroinflammation and oxidative stress; decrease of plasma corticosterone and protection against hyperchromatic nuclei in the brain.
In Vitro Analysis of Anticancer Potential of Green Okra (Abelmoschus esculentus L.) Polysaccharide Extracts in HeLa Cervical Cancer Cell Line
Authors: Musthoza Fina Syifa’una , Kuncoroningrat Susilo Raden Joko , Hayaza Suhailah , A’ yun Qurrotu , Fikriyah Nur’aini , Islamatasya Ufairanisa , Winarni Dwi , Astuti Wahyuningsih Sri Puji , Doong Ruey-an , Karsari Deya , Dinar Yanti Aristika , Umi Rohmatika Aulia , Darmanto Win
Published: October 2023

Polysaccharide extract has potential as an anticancer agent. Abelmoschus esculentus is one of the plants that is rich in polysaccharide content, but its anticancer activity is still need explore. This study aimed to explore the anticancer activity of Abelmoschus esculentus crude extract polysaccharide by measure the effect on levels of pro-inflammatory cytokines IL-2, IL-12, TNF-α, IFN-γ in HeLa cell line. This study used HeLa cells as a research model with four groups, including KN (media and DMSO), K+ (doxorobicin µg/mL), P1 (Abelmoschus esculentus L. extract 200µg/mL) and P2 (Abelmoschus esculentus L. extract 400µg/mL). The Abelmoschus esculentus L. was extracted using boiled distilled water. Cytokine levels were analyzed using the ELISA test. The results of cytokine levels showed decreasing in the levels of cytokines IL-2, IL-12, TNF-α, IFN-γ, (P < 0.005). In conclusion, the polysaccharide extract of Abelmoschus esculentus L. has the potential as an anticancer and therapeutic agent for cancer. Research on green okra polysaccharide crude extract as an immunosuppressant is expected to be a potential bio-pharmaceutical source.
Analytical correlation of Laboratory tests with clinical findings in cases of Paraproteinemia
Authors: Zacharias Emilin , A Manjrekar Poornima , K Sowndarya , Sindhu Sindhu
Published: October 2023

Multiple myeloma is a malignant plasma cell disorder identified with M spikeon serum protein electrophoresis (SPE) during routine laboratory work up. This study aimed to analyze the utility of laboratory tests suchas SPE, immunofixation electrophoresis (IFE), CBC, RFT, LFT, calcium, phosphorus, beta 2 microglobulins, LDH, serum-free light chain assay (SFLC), Bence Jones Proteinuria (BJP), BM biopsy, BM smear and radiological evidence for lytic lesionsin cases of paraproteinemia. Data for the above parameters from 2017 January to 2021 March were obtained from the data management system of the central lab. Biochemical parameters were correlated with M spike value using Karl Pearson’s correlation coefficient (P-value <0.05 will be significant).7.7% SPE reports had M spike with a mean age of 64 years in males and 63 years in females (male/female ratio, 1: 0.76). M spike showed a significant positive association with total protein, globulin, uric acid and negative association with albumin. IgG kappa type (51%) predominant in IFE reports. The common presentation from hematological data was normocytic normochromic anemia with occasional rouleaux formation. Osteolytic lesion was present in 86% of reported cases. Associated biochemical, hematological, and radiological correlates of the positive cases could be documented in only less than 20% of the positive cases. Ours is a tertiary care hospital and the associated lab is also a reference lab where samples from in and around the city are tested. After the preliminary SPE, it could be possible that the patients were further evaluated and continued treatment at some other facility.
Spectrophotometric method development and validation for determination of pazopanib in the bulk and the formulation
Authors: Mishra Ramendu , Devi Anjana
Published: October 2023

The present work is performed on analytical method development with its latter validation study of a simple and accurate UV-Visible spectrophotometric method for the content determination of the Pazopanib HCl (PAZ). The optimum conditions and solvent selection for the analysis of the drug were established. Absorption maxima (λmax) taken for the analysis was 267nm in the purposed medium. Calibration curve was obtained and plotted against the observed values. Validation of the method was performed as per the current ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The method is simple, accurate, sensitive, precise and reproducible. The method can be used in IPQC and QC testing on a commercial stage as well as in small scale labs, as the method is economical and cheap. The analysis is done on UV-Visible spectrophotometer which is easily available in every institute or in small labs as well.
Knowledge towards COVID-19 preventive measures, and beliefs on use of herbal products as protective measure against COVID-19 infection
Authors: Binti Mazlan Nurliyana Najihah , Ahsan Aftab Raja , Hadi Nor Afendi Nor Safwan , A/L S. Rajendram Santhanathan , Patro Sisinthy Sreenivas
Published: October 2023

To assess the knowledge towards COVID-19 preventive measures and symptoms, and belief on herbal supplement as protective measure against COVID-19 infection among general public in Malaysia. A cross sectional survey questionnaire was conducted among 423 respondents that comprised of three (3) different sections consisting as Section A (demographics characteristics of the respondents). Section B (evaluation of respondent’s knowledge towardsCOVID-19 preventive measures and symptoms) and Section C (evaluation of respondent’s belief about use of herbal products during COVID-19 pandemic).Overall, a good knowledge towards COVID-19 preventive measures and symptoms, and moderate belief on herbal supplement as protective measure against COVID-19 infection was observed. Mean knowledge score was found to be 10.38±1.56 whereas mean belief scores were 36.6±6.52. Also, a significant association was observed between respondent’s occupation (p = 0.029) with knowledge towards COVID-19 preventive measures and symptoms. Furthermore, the relationship between respondent’s knowledge towards COVID-19 preventive measure and symptoms, and respondent’s belief on herbal supplement as protective measure against COVID-19 infection was insignificant (p = 0.053). A good knowledge towards COVID-19 preventive measures and symptoms, and moderate belief on herbal supplement as protective measure against COVID-19 infection.
ГЕНЕТИЧЕСКИЕ ОСОБЕННОСТИ ТЕЛОСЛОЖЕНИЯ БАРАНЧИКОВ РОМАНОВСКОЙ ПОРОДЫ И ЕЕ ПОМЕСЕЙ С ЭДИЛЬБАЯМИ
Authors: Комарова Нина , Рахимжанова Ильмира , Миронова Ирина , Губайдуллин Наиль , Гадиев Ринат , Газеев Игорь
Published: October 2023

Приводятся показатели возрастной динамики основных промеров тела чистопородных баранчиков романовской породы и ее помесей с эдильбаями первого поколения (½ эдильбай × ½ романовская) и второго поколения (¾ эдильбай × ¼ романовская). Установлено, что помесный молодняк во все возрастные периоды превосходил чистопородных баранчиков по уровню всех промеров тела, что обусловлено проявлением эффекта скрещивания. При этом в конце выращивания в 10- месячном возрасте чистопородные баранчики романовской породы уступали помесным сверстникам по высоте в холке на 2,30 см (3,83 %) и 4,32 см (7,19 %), высоте в крестце – на 1,03 см (1,66 %) и 4,89 см (7,92 %), косой длине туловища (палкой) – на 4,11 см (6,51 %) и 7,13 см (11,30 %), глубине груди – на 2,44 см (10,43 %) и 4,66 см (19,91 %), ширине груди – на 3,06 см (18,84 %) и 5,17 см (31,48 %), обхвату груди за лопатками – на 4,02 см (4,90 %, Р<0,01) и 8,00 см (9,76 %), обхвату пясти – на 0,17 см (2,18 %) и 1,21 см (15,49 %). Лидирующее положение по величине всех промеров тела занимали помесные баранчики второго поколения. Установлено, что минимальной величиной коэффициента увеличения с возрастом отличались промеры обхват пясти (1,60-1,61), высота в холке (1,86-1,88) и высота в крестце (1,82-1,85), а максимальным его уровнем обхват груди за лопатками (3,05-3,08), ширина груди (2,98-3,05) и косая длина туловища (палкой) (2,83-2,86).
МОРФОЛОГИЧЕСКИЕ ПОКАЗАТЕЛИ ВЫМЕНИ КОРОВ ТАДЖИКСКОЙ ЧЕРНО-ПЕСТРОЙ ПОРОДЫ В УСЛОВИЯХ ХОЗЯЙСТВ «БАРАКАТИ ЧОРВОДОР» ГОРОДА ГИССАРА
Authors: Риоева Н. , Рузиев Х. , Икромов Ф. , Абдурасулов А.
Published: October 2023

В статье приводится материалы по оценке морфологические показатели вымени коров таджикской черно-пестрой породы. Результаты проведенных опытов показали, что наиболее емкостное вымя имели коровы I-ой группы (15,0 кг), что составляет 59,5 % от суточного удоя. Коровы I-ой группы превосходят емкость молочной железы коров с чашеобразным выменем на 3,3 % (Р˃0,99) и на 9,0 % (Р˃0,999) коров с округлым выменем. При изучении формы сосков у подопытных животных наблюдалось 4 типа сосков: цилиндрическая, коническая, карандашевидная и грушевидная. Из них 44,4 % коров первотелок имели цилиндрическую, 40,0 % коническую и 15,6% имели нежелательные формы: 11,1% карандашевидную и 4,5% грушевидную. У первотелок I-ой группы 46,7 %; животных имели цилиндрическую форму сосков, II-ая группа показала аналогичный результат, коровы первотелки III-ей группы уступали на 6,7 % (Р˃0,999). У40,0 % опытных коров I-ой группы была коническая форма сосков, 46,7 % животных II-ой группы и 33,3 % коров III-ей группы.
ЭФФЕКТИВНОСТЬ ИСПОЛЬЗОВАНИЯ ГОЛШТИНСКИХ ПРОИЗВОДИТЕЛЕЙ ПРИ ВЫВЕДЕНИИ ТАДЖИКСКОЙ ЧЕРНО-ПЕСТРОЙ ПОРОДЫ
Authors: Рузиев Хуршед , Рузиев Туйчи , Мастов Абдуджабор
Published: October 2023

В статье приводится материалы по эффективному использованию быков голштинской породы при выведении таджикской черно-пестрой породы в условиях республики Таджикистана. Как в хозяйствах Северной части, так и в хозяйствах Центральной части при скрещивании с голштинскими быками, генетический тренд по удою и количеству молочного жира был соответственно высоким. У потомков таджикского типа черно-пестрой породы по хозяйствам Северной части среднегодовое генетическое улучшение удоя составило +49,6 кг молока, а по хозяйствам Центральной части оно было +68,6 кг молока.  Молочный жир соответственно составило 142, 1 и 181,5 кг. Влияние быков-производителей на дочерей по хозяйствам Центральной части по сравнению с хозяйствами Северной части составляет 1006 кг. Это подтверждает того, что высокопродуктивные племенные заводы находятся в территории хозяйств Центральной части республики.
НИКОТИНДИ АЛУУ ҮЧҮН КУЛЬТИВАЦИЯЛООДО ТАМЕКИ ЗАВОДУНУН МОРФОЛОГИЯЛЫК, ФЕНОЛОГИЯЛЫК ЖАНА БИОМЕТРИЯЛЫК КӨРСӨТКҮЧТӨРҮ
Authors: Смаилов Элтар , Абдуллаева Рахат
Published: October 2023

Шарттуу сугарылуучу боз топуракта өстүрүлгөн тамеки өсүмдүгү (сорт Талгар 28, скелет сорту чоң жалбырактуу, кыртыштын нымдуулугу 40%) жөнүндө маалымат берилген. Талгар 28 ири жалбырактуу тамекисинин морфологиялык, фенологиялык жана биометрикалык көрсөткүчтөрү кадимки сиэроземдерде, THC 40% топурактын нымдуулугунда N120, P120K120 жер семирткичтерин никотин алуу үчүн колдонууда жана жер семирткичсиз өстүрүүдө аныкталган. Жер семирткичтер чачылганбы же чачылганбы, карабастан, тамеки өсүмдүктөрүнүн гүлдөшүнүн бүт өсүмдүктүн, анын аба бөлүгүнүн жана тамыр системасынын өсүшүнүн интенсивдүүлүгүнө жана салмак кошуусуна тийгизген таасири жана байланышы аныкталган.
МОНИТОРИНГ ЭПИЗООТИЧЕСКОГО СИТУАЦИИ ПО ПАРАЗИТОЗАМ У ЖВАЧНЫХ ЖИВОТНЫХ В УСЛОВИЯХ ВЫСОКОГОРЬЯ
Authors: Абдурасулов А. , Исаев М. , Карипов К. , Муратова Р. , Халмурзаев А. , Абдымомунов И. , Маматкалыков П. , Кочконбаева Н. , Джумагулов Ж. , Абдурасулов И.
Published: October 2023

По исследовании ряд ученых паразитарные болезни животных в индивидуальных частных хозяйствах, в сравнении с сельскохозяйственными, кооперативными предприятиями, имеют более широкое распространение. Это связано, что скот в личных подворьях практически не исследуют на наличие паразитов, и редко подвергают противопаразитарным обработкам. Работа выполнена на кафедре ветеринарной медицины и биотехнологии Ошского государственного университета, а также в фермерских и индивидуальных хозяйствах высокогорных районах Алайского, Чон-Алайского и Кара-Кульжинского районов Ошской области по инвазионным болезням животных. Исследования проводили в осенне-зимний период, всего исследовано пробы фекалий от 206 голов жвачных животных, в том числе от 86 голов крупного рогатого скота и 122 голов овец и коз. Гельминто-копрологическими исследованиями обнаружены следующие ассоциации паразитов: эймерии в 49,2%, дикроцелии 37,7%, стронгиляты 20,5%, нематодиры 19,7%, трихоцефалы 16,4%, фациолы 3,3% случаев. Из обследованных 86 голов крупного рогатого скота эймерии выделено в 46,5% случаев, стронгиляты в 20,9%, дикроцелии в 20,9%,  нематодиры в 16,2%, трихоцефалы в 15,1%, а фациолы  в 2,3% случаев.
ЭФФЕКТИВНОСТЬ ИСПОЛЬЗОВАНИЯ ОРГАНИЗМОМ ТЕЛЯТ ИМУНОГЛОБУЛИНОВ МОЛОЗИВА ПРИ РАЗЛИЧНОЙ ИНТЕНСИВНОСТИ ЕГО ПОТРЕБЛЕНИЯ
Authors: Карамаева Анна , Карамаев Сергей , Валитов Хайдар
Published: October 2023

Изучено влияние скорости потребления молозива на интенсивность усвоения иммуноглобулинов в организме новорожденных телят с учетом их концентрации в сыворотке крови через 6 ч после первой выпойки. Объектом исследований служили новорожденные телята основных молочных пород крупно рогатого скота, разводимых в природно-климатической зоне Среднего Поволжья и Южного Урала. Исследования показали, что чем меньше относительная масса телят при рождении, тем легче проходит отёл, телята отличаются большей энергичностью и жизнеспособностью, у них быстрее проявляются биологически обусловленные физиологические функции организма. Установлено, что практически при одинаковой относительной массе потребленного при первом выпаивании молозива – 4,8-5,2% от живой массы телёнка, самая низкая скорость потребления молозива (70,2 глотка/мин) была у бестужевской породы. При этом телята делали за время подсоса 548,2 глотка, что больше, чем у чёрно-пёстрой породы на 7,6%, голштинской – на 1,7%, айрширской – на 4,3%, но величина глотка составила 2,7 г и была меньше, чем у сверстников соответственно на 15,6; 34,1; 22,9%. Биохимический анализ крови показал, что самая высокая концентрация иммуноглобулинов была при скорости потребления молозива 61-70 глотков/мин. В результате отмечена тенденция, что с увеличением скорости потребления молозива, уменьшается содержание в крови телят иммуноглобулинов, через 6 ч после выпойки, на 5,9-12,3%; 4,5-11,1%; 4,4-13,9%; 3,8-14,5%.
АНАТОМО-ТОПОГРАФИЧЕСКИЕ ОСОБЕННОСТИ ЗАДНЕБЕДРЕННОЙ ГРУППЫ МЫШЦ РАЗГИБАТЕЛЕЙ ТАЗОБЕДРЕННОГО СУСТАВА У ЕВРОПЕЙСКОЙ КОСУЛИ
Authors: Слесаренко Наталья , Оганов Эльдияр , Широкова Елена
Published: October 2023

В статье представлены анатомические особенности заднебедренной группы разгибателей тазобедренного сустава у Европейской косули, отсутствующие в доступной литературе. Исследования выполнены на кафедре анатомии и гистологии животных им. профессора А.Ф. Климова ФГБОУ ВО «Московская государственная академия ветеринарной медицины и биотехнологии – МВА имени К.И. Скрябина». Материалом для исследований служил секционный материал- тазовые конечности (n=6), отобранные от взрослых Европейских косуль, без внешних признаков патологий опорно-двигательного аппарата. Установлены топические особенности анатомических образований седалищного бугра у Европейской косули – дорсальный, латеральный и вентральный выросты. Вентральный вырост у косули находится ниже и несколько медиальнее дорсального выроста, в связи с чем, его можно называть вентральным выступом.  На седалищной кости также «площадка и линия квадратной мышцы». На дистальной трети бедренной кости, на медиальной ей поверхности – «площадка» и «линия полуперепончатой мышцы, а в проксимальной части кости – «площадка сухожилия квадратной кости».
КАЧЕСТВО МЯСНОЙ ПРОДУКЦИИ БЫЧКОВ ПРИ СКАРМЛИВАНИИ ФЕЛУЦЕН
Authors: Курохтина Дарья , Никонова Елена , Рахимжанова Ильмира , Бабичева Ирина
Published: October 2023

Объектом  исследований являлись бычки казахской белоголовой породы 18 –месячного возраста, у которых был изучен сортовой состав мясной продукции, а также промеры длиннейшей мышцы спины при скармливании им в рационе сбалансированного углеводного кормового комплекса Фелуцен. В результате исследований установлено, что максимальной величиной  показателей, бычки опытной , бычки и опытных уступали III группы абсолютной мяса сорта 6,9 % и 3,5 %, – на 0,3 % 0,2%, массе I соответственно 6,1 % и 2,9 %, 0,4% 0,2 %. При анализе морфометрических показателей длиннейшей мышцы спины установлено превосходство бычков III группы над сверстниками и опытных по длиннейшей спины на 5,9% 2,9%, ширине – 4,0% и 2,4%. «мышечного » - на 8,56 (10,2%, Р<0,01) 4,68 дм2 (5,3%, <0,01).
О СРОКАХ ХОЗЯЙСТВЕННОГО ИСПОЛЬЗОВАНИЯ КОРОВ ЧЁРНО-ПЁСТРОЙ ПОРОДЫ В УСЛОВИЯХ ТАДЖИКИСТАНА
Authors: Рузиев Хуршед , Рузиев Туйчи , Абдурасулов Абдугани
Published: October 2023

В статье приводится материалы по продуктивному долголетию коров таджикского типа черно-пестрой породы в условиях интенсивной технологии производства молока. Установлено, что в зависимости от того, что племенные заводы расположены в центральной и северной части республики продуктивное долголетие у коров разные. В хозяйстве им. Л.Муродов коров используют до 7,12 лактации, а у хозяйств им. А.Юсупова и «Баракат»- 6,54 и 6,80 лактации. Коровы хозяйство им. Л.Муродов превосходили коров хозяйство им. А.Юсупова и «Баракат» по пожизненному удою на 17,4 % и 6,1%, по общему количество молочного жира на 17,1 и 6,1%. Продолжительность использования коров в хозяйствах в последующих лактациях показатели снижаются. В хозяйствах Северной части также использование коров по-разному. В хозяйстве «Навгилем» Исфаринского района их используют до 6,64 лактации. Пожизненный удой у них составила 22534 кг, что больше по сравнению с другими хозяйств на 1186 кг (5,5%) и 3526кг (18,5%) (Р   0,999). По выходу молочного жира, также они превосходили на 42,9 кг (5,2 %) и 133,9 кг (18,5%).