bluuebunny/crossref_metadata_2025 huggingface dataset:
Motor Learning Relies on Integrated Sensory Inputs in ADHD, but Over‐Selectively on Proprioception in Autism Spectrum Conditions
Authors: Izawa Jun , Pekny Sarah E. , Marko Mollie K. , Haswell Courtney C. , Shadmehr Reza , Mostofsky Stewart H.
Published: February 2012

The brain builds an association between action and sensory feedback to predict the sensory consequence of self‐generated motor commands. This internal model of action is central to our ability to adapt movements and may also play a role in our ability to learn from observing others. Recently, we reported that the spatial generalization patterns that accompany adaptation of reaching movements were distinct in children with autism spectrum disorder (ASD) as compared with typically developing (TD) children. To test whether the generalization patterns are specific to ASD, here, we compared the patterns of adaptation with those in children with attention deficit hyperactivity disorder (ADHD). Consistent with our previous observations, we found that in ASD, the motor memory showed greater than normal generalization in proprioceptive coordinates compared with both TD children and children with ADHD; children with ASD also showed slower rates of adaptation compared with both control groups. Children with ADHD did not show this excessive generalization to the proprioceptive target, but they did show excessive variability in the speed of movements with an increase in the exponential distribution of responses (τ) as compared with both TD children and children with ASD. The results suggest that slower rate of adaptation and anomalous bias towards proprioceptive feedback during motor learning are characteristics of autism, whereas increased variability in execution is a characteristic of ADHD. Autism Res 2012,••:••–••. © 2012 International Society for Autism Research, Wiley Periodicals, Inc.
Randomized comparison of self-fixating and sutured mesh in open inguinal hernia repair
Authors: Pierides G , Scheinin T , Remes V , Hermunen K , Vironen J
Published: February 2012

Background

Chronic groin pain after mesh repair of inguinal hernia has been attributed to the presence of sutures.

Methods

This randomized clinical trial compared inguinal hernia repair using a self-fixating composite mesh or a sutured lightweight mesh, with pain at 1 year as primary outcome. Patients completed a self-evaluation questionnaire at 2 weeks and were examined after 1 year.

Results

Some 198 patients received self-fixating mesh and 196 sutured mesh. There were no differences between the groups in mean pain scores measured on a visual analogue scale during 2 weeks of immediate convalescence or at 1 year. Chronic pain and discomfort was experienced by 36·3 per cent of patients in the self-fixating and 34·1 per cent in the sutured mesh group (P = 0·658), affecting the everyday life of 1·1 and 2·8 per cent respectively (P = 0·448).

Conclusion

Open inguinal hernia repair with a composite self-fixating mesh resulted in similar pain in the early postoperative convalescence period and at 1 year as repair with a sutured lightweight mesh. Registration number: NCT01026935 (http://www.clinicaltrials.gov).
Characterization of a Single Gene Cluster Responsible for Methylpendolmycin and Pendolmycin Biosynthesis in the Deep Sea Bacterium Marinactinospora thermotolerans
Authors: Ma Junying , Zuo Dianguang , Song Yongxiang , Wang Bo , Huang Hongbo , Yao Yueliang , Li Wenjun , Zhang Si , Zhang Changsheng , Ju Jianhua
Published: February 2012

The nine‐membered indolactam antibiotics belong to a small group of antibiotics showing broad biological activities. However, the in vivo genetic engineering of compounds of this type has not been performed. Here we report the identification of a single gene cluster responsible for the biosynthesis of methylpendolmycin and pendolmycin, two members of this family of antibiotics, from the deep sea bacterium Marinactinospora thermotolerans SCSIO 00652. Bioinformatics analysis and gene inactivation, coupled with metabolite characterization, reveal that MpnB, a nonribosomal peptide synthetase, MpnC, a cytochrome P450, and MpnD, a prenyltransferase, are sufficient to catalyze the biosynthesis of the two antibiotics from L‐Ile (or L‐Val), L‐Trp, and methionine. MpnD is the first identified enzyme that transfers a C5 prenyl unit in a reverse manner to the C‐7 position of a Trp‐derived natural product.
Mechanism of PtIV Sonochemical Reduction in Formic Acid Media and Pure Water
Authors: Chave Tony , Navarro Nathalie M. , Nitsche Serge , Nikitenko Sergey I.
Published: February 2012

Sonochemical synthesis of platinum nanoparticles (Pt NPs) in formic acid solutions and pure water was investigated using a 20 kHz ultrasonic irradiation. The obtained results gave new insights on the underneath PtIV reduction mechanism in formic acid media under argon and in pure water under Ar/CO atmosphere. It was shown that in pure water sonochemical reduction of platinum ions occurs by hydrogen issued from homolytic water molecule split. PtIV ion reduction appears to be a very slow process under argon atmosphere in pure water due to formation of oxidizing species like OH radicals and H2O2 leading to reoxidation of intermediate PtII ions. Sonochemical reduction is accelerated manifold in the presence of formic acid or Ar/CO gas mixture. Solution and gas‐phase analyses reveal that both CO and HCOOH act as OH. radical scavenger and reducing agent under ultrasonic irradiation. Their ability to reduce platinum ions at room temperature is enhanced due to the local heating in the liquid shell surround the cavitation bubble. An innovative synthesis route for monodispersed Pt NPs in pure water without any templates or capping agents in the presence of Ar/CO gas mixture is then proposed. Obtained Pt NPs within the range of 2–3 nm exhibited a strong stability towards sedimentation in water. Since Ar/CO atmosphere is the only restriction of the process, this procedure can be applied in various media and is also compatible with a large array of experimental conditions.
Photocatalytic Hydrogen Evolution Based on Efficient Energy and Electron Transfers in Donor–Bridge–Acceptor Multibranched‐Porphyrin‐Functionalized Platinum Nanocomposites
Authors: Zhu Mingshan , Dong Yupei , Du Yukou , Mou Zhigang , Liu Jian , Yang Ping , Wang Xiaomei
Published: February 2012

Two donor–bridge–acceptor conjugates (5,10,15,20‐tetrakis[4‐(N,N‐diphenylaminobenzoate)phenyl] porphyrin (TPPZ) and 5,10,15,20‐tetrakis[4‐(N,N‐diphenylaminostyryl)phenyl] porphyrin (TPPX)) were covalently linked to triphenylamine (TPA) at the meso‐position of porphyrin ring. The triphenylamine entities were expected to act as energy donors and the porphyrins to act as an energy acceptor. In this paper, we report on the synthesis of these multibranched‐porphyrin‐functionalized Pt nanocomposites. The conjugates used here not only served as a stabilizer to prevent agglomeration of Pt nanoparticles, but also as a light‐harvesting photosensitizer. The occurrence of photoinduced electron‐transfer processes was confirmed by time‐resolved fluorescence and photoelectrochemical spectral measurements. The different efficiencies for energy and electron transfer in the two multibranched porphyrins and the functionalized Pt nanocomposites were attributed to diverse covalent linkages. Moreover, in the reduction of water to produce H2, the photocatalytic activity of the Pt nanocomposite functionalized by TPPX, in which the triphenylamine and porphyrin moieties are bonded through an ethylene bridge, was much higher than that of the platinum nanocomposite functionalized by TPPZ, in which the two moieties are bonded through an ester. This investigation demonstrates the fundamental advantages of constructing donor–bridge–acceptor conjugates as highly efficient photosensitizers based on efficient energy and electron transfer.
The More Gold—The More Enantioselective: Cyclohydroaminations of γ‐Allenyl Sulfonamides with Mono‐, Bis‐, and Trisphospholane Gold(I) Catalysts
Authors: Rodríguez Lara‐Isabel , Roth Torsten , Lloret Fillol Julio , Wadepohl Hubert , Gade Lutz H.
Published: February 2012

A series of chiral mono‐, di‐, and trinuclear gold(I) complexes have been prepared and used as precatalysts in the asymmetric cyclohydroamination of N‐protected γ‐allenyl sulfonamides. The stereodirecting ligands were mono‐, di‐, and tridentate 2,5‐diphenylphospholanes, which possessed C1, C2, and C3 symmetry, respectively, thereby rendering the catalytic sites in the di‐ and trinuclear complexes symmetry equivalent. The C3‐symmetric trinuclear complex displayed the highest activity and enantioselectivity (up to 95 % ee), whilst its mono‐ and dinuclear counterparts exhibited considerably lower enantioselectivities and activities. A similar trend was observed in a series of mono‐, di‐, and trinuclear 2,5‐dimethylphospholane gold(I) complexes. Aurophilic interactions were established from the solid‐state structures of the trinuclear gold(I) complexes, thereby raising the question as to whether these secondary forces were responsible for the different catalytic behavior observed.
Theoretical and Experimental Exploration of the Energy Landscape of the Quasi‐Binary Cesium Chloride/Lithium Chloride System
Authors: Pentin Ilya V. , Saltykov Vyacheslav , Nuss Jürgen , Schön J. Christian , Jansen Martin
Published: February 2012

As a case study, the energy landscape of the cesium chloride/lithium chloride system was investigated by combining theoretical and experimental methods. Global optimization for many compositions of this quasi‐binary system gave candidates for possible modifications that constitute promising targets for subsequent syntheses based on solid‐state reactions. Owing to the synergetic and complementary nature of the computational and experimental approaches, a substantially better efficiency of exploration was achieved. Several new phases were found in this system, for the compositions CsLiCl2 and CsLi2Cl3, and their thermodynamic ranking with respect to the already‐known phases was clarified. In particular, the new CsLiCl2 modification was shown to be the low‐temperature phase, whilst the already‐known modification for this composition corresponded to a high‐temperature phase. Based on these results, an improved cesium chloride/lithium chloride phase diagram was derived, and this approach points the way to more rational and more efficient solid‐state synthesis.
Miniaturization of Metal–Biomolecule Frameworks Based on Stereoselective Self‐Assembly and Potential Application in Water Treatment and as Antibacterial Agents
Authors: Pu Fang , Liu Xia , Xu Bailu , Ren Jinsong , Qu Xiaogang
Published: February 2012

Miniaturization of metal–biomolecule frameworks (MBioFs) to the nanometer scale represents a novel strategy for fabricating materials with tunable physical and chemical properties. Herein, we demonstrate a simple, low‐cost, and completely organic solvent‐free strategy for constructing a dl‐glutamic acid–copper ion‐based three‐dimensional nanofibrous network structure. The building blocks used are available in large quantities and do not require any laborious synthesis or modification. Importantly, we demonstrate with an intriguing example, that the self‐assembly ability of supramolecular nanofibers could be finely tuned with the ligands’ chirality. This offers opportunities for obtaining one‐dimensional hierarchical nanostructures and expands the investigation scope of stereoselective self‐assembly. Furthermore, the material displays good ability in removing anionic dyes from water and inhibits the growth of both Gram positive and Gram negative bacteria, possibly through the contact‐killing mechanism; this indicates potential applications in environmental issues and antimicrobial nanotherapeutics.
Hydrogen‐Bond‐Mediated Asymmetric Cascade Reaction of Stable Sulfur Ylides with Nitroolefins: Scope, Application and Mechanism
Authors: Lu Liang‐Qiu , Li Fang , An Jing , Cheng Ying , Chen Jia‐Rong , Xiao Wen‐Jing
Published: February 2012

A hydrogen‐bond‐mediated asymmetric [4+1] annulation/rearrangement cascade of stable sulfur ylides and nitroolefins was developed. This reaction provides a facile route to enantioenriched 4,5‐substituted oxazolidinones in moderate to excellent isolated yields (65–96 %) with excellent stereocontrol (up to more than 95:5 d.r. and 97:3 e.r.). This methodology was successfully applied to the concise synthesis of two bioactive molecules. The stereocontrolled modes and mechanism have been proposed to explain the origin of this stereochemistry.
ChemInform Abstract: Sr2GaScO5, Sr10Ga6Sc4O25, and SrGa0.75Sc0.25O2.5: A Play in the Octahedra to Tetrahedra Ratio in Oxygen‐Deficient Perovskites.
Authors: Istomin Sergey Ya. , et al. et al.
Published: February 2012

The title compounds are prepared by the polyacrylamide gel method from aqueous solutions of stoichiometric mixtures of Sc2O3, Ga2O3, and SrCO3 containing in addition citric acid, HNO3, NH3, acrylamide, N,N′‐methylenediacrylamide, and azoisobutyronitrile.
ChemInform Abstract: Excellent Red Phosphors of Double Perovskite Ca2LaMO6:Eu (M: Sb, Nb, Ta) with Distorted Coordination Environment.
Authors: Yin Xin , Wang Yaoming , Huang Fuqiang , Xia Yujuan , Wan Dongyun , Yao Jiyong
Published: February 2012

Ca2LaSbO6 (obtained by solid state reaction at 1400 °C for 24 h) crystallizes in the monoclinic space group P21/n (powder XRD) isostructurally to Ca2LaMO6 (M: Nb, Ta).
ChemInform Abstract: Electrical, Optical, and Thermoelectric Properties of Ga2O3(ZnO)9.
Authors: Michiue Yuichi , Mori Takao , Prytuliak Anastasiia , Matsushita Yoshitaka , Tanaka Masahiko , Kimizuka Noboru
Published: February 2012

The title compound is prepared by reaction of Ga2O3 and ZnO in the molar ratio of 1:9 (1723 K, 8 d) and characterized by powder XRD, UV/VIS spectroscopy, electrical conductivity, and thermoelectric measurements.
ChemInform Abstract: Crystal Growth and Structure of the New Ferrimagnetic Oxyphosphate PbFe3O(PO4)3.
Authors: El Hafid Hassan , Velazquez Matias , Perez Olivier , El Jazouli Abdelaziz , Pautrat Alain , Decourt Rodolphe , Veber Philippe , Viraphong Oudomsack , Delmas Claude
Published: February 2012

Polycrystalline PbFe3O(PO4)3 is prepared by coprecipitation from an aqueous solution of Pb(NO3)2, Fe(NO3)3, and (NH4)2HPO4 followed by sintering at 880 °C for 72 h.
ChemInform Abstract: Photoreduction of 99Tc Pertechnetate by Nanometer‐Sized Metal Oxides: New Strategies for Formation and Sequestration of Low‐Valent Technetium.
Authors: Burton‐Pye Benjamin P. , Radivojevic Ivana , McGregor Donna , Mbomekalle Israel M. , Lukens Wayne W. Jr. , Francesconi Lynn C.
Published: February 2012

K10 (α2‐P2W17O61) is photoactivated in the presence of iPrOH to reduce 99TcO4‐ (or ReO4‐) and incorporate the reduced 99TcV (or ReV) covalently into the α2‐framework to form the 99TcVO (α2‐P2W17O61)7‐ (or ReVO (α2‐P2W17O61) 7‐) species.
ChemInform Abstract: Structural Proof for a Higher Polybromide Monoanion: Investigation of [N(C3H7)4][Br9].
Authors: Haller Heike , Ellwanger Mathias , Higelin Alexander , Riedel Sebastian
Published: February 2012

[Pr4N][Br9] is synthesized by the reaction of [Pr4N]Br and excess bromine (20 °C, several days) and characterized by single crystal XRD, IR and Raman spectroscopy, conductivity measurements, and quantum chemical calculations at various levels of DFT and at ab initio HF, MP2, SCS‐MP2, SOS‐MP2, CCSD, and CCSD(T) level.
ChemInform Abstract: Crystalline Open‐Framework Selenidostannates Synthesized in Ionic Liquids.
Authors: Li Jian‐Rong , Xie Zai‐Lai , He Xiao‐Wu , Li Long‐Hua , Huang Xiao‐Ying
Published: February 2012

Crystalline chalcogenides are prepared in ionic liquids containing N2H4·H2O leading to a well‐controlled crystallization process.
ChemInform Abstract: Synthesis, Crystal Structure and Physico‐Chemical Properties of the New Quaternary Oxide Sr5BiNi2O9.6.
Authors: Strobel Pierre , et al. et al.
Published: February 2012

The new title compound is synthesized by solid state reaction of Sr(NO3)2, Bi(NO3)3, and Ni(NO3)2 (air or O2, 1200 °C, 24 h).
ChemInform Abstract: Palladium‐Catalyzed Regio‐ and Enantioselective Fluorination of Acyclic Allylic Halides.
Authors: Katcher Matthew H. , Sha Allen , Doyle Abigail G.
Published: February 2012

Linear allylic chlorides or bromides are fluorinated with high selectivity for the branched products in the presence of chiral bisphosphine‐ligated palladium catalysts.
ChemInform Abstract: (1R,2R)‐Bis[(S)‐prolinamido]cyclohexane Modified with Ionic Groups: The First C2‐Symmetric Immobilized Organocatalyst for Asymmetric Aldol Reactions in Aqueous Media.
Authors: Kochetkov Sergei V. , Kucherenko Alexandr S. , Zlotin Sergei G.
Published: February 2012

Catalyst (I) can be recovered and reused at least 10 times without any decrease in the reaction rate or selectivity.
ChemInform Abstract: Catalytic Asymmetric Thiofunctionalization of Unactivated Alkenes.
Authors: Denmark Scott E. , Kornfilt David J. P. , Vogler Thomas
Published: February 2012

A chiral selenophosphoramide catalyst is used for the asymmetric sulfenylation of simple alkenes and styrenes to afford sulfenylated tetrahydrofurans and tetrahydropyrans.
ChemInform Abstract: Selective Cross‐Coupling of Amines by Alumina‐Supported Palladium Nanocluster Catalysts.
Authors: Shimizu Ken‐ichi , Shimura Katsuya , Ohshima Keiichiro , Tamura Masazumi , Satsuma Atsushi
Published: February 2012

Alumina‐supported Pd nanoclusters are prepared and applied as a reusable heterogeneous catalyst for amine cross‐coupling reactions.
ChemInform Abstract: New Electrophilic Addition of α‐Diazoesters with Ketones for Enantioselective C—N Bond Formation.
Authors: Li Wei , Liu Xiaohua , Hao Xiaoyu , Hu Xiaolei , Chu Yangyang , Cao Weidi , Qin Song , Hu Changwei , Lin Lili , Feng Xiaoming
Published: February 2012

The reaction occurs in the presence of an N,N′‐dioxide—scandium complex generated in situ under mild conditions.
ChemInform Abstract: Copper‐Catalyzed Trifluoromethylation of Terminal Alkenes Through Allylic C—H Bond Activation.
Authors: Xu Jun , Fu Yao , Luo Dong‐Fen , Jiang Yuan‐Ye , Xiao Bin , Liu Zhao‐Jing , Gong Tian‐Jun , Liu Lei
Published: February 2012

The present new type of Cu‐catalyzed trifluoromethylation reaction of terminal alkenes occurs with high regioselectivity tolerating various functional groups including epoxides, nitro, ester, amine and hydroxyl groups.
ChemInform Abstract: Highly Enantioselective Intermolecular Alkylation of Aldehydes with Alcohols by Cooperative Catalysis of Diarylprolinol Silyl Ether with Broensted Acid.
Authors: Xiao Jian , Zhao Kai , Loh Teck‐Peng
Published: February 2012

Using cyclic alcohol (I) and acyclic alcohol (IV), alkylation reactions are performed in the presence of 2,3,4‐trihydroxybenzoic acid.
ChemInform Abstract: Polymer‐Supported Macrocyclic Schiff Base Palladium Complex as an Efficient Catalyst for the Heck Reaction.
Authors: He Ying , Cai Chun
Published: February 2012

A variety of aryl iodides and bromides is successfully coupled towards acrylate (I) or styrene (IV) in the presence of a novel polystyrene‐bound macrocyclic Pd(II) catalyst.
ChemInform Abstract: Metal—Ligand Cooperation in the Catalytic Dehydrogenative Coupling (DHC) of Polyalcohols to Carboxylic Acid Derivatives.
Authors: Trincado Monica , Kuehlein Klaus , Gruetzmacher Hansjoerg
Published: February 2012

A dehydrogenative coupling process of various polyols, catalyzed by a rhodium diolefin amido complex or its salt, allows the preparation of the carboxylic amides and acids.
ChemInform Abstract: Stereoselective Synthesis of Trisubstituted Olefins by a Directed Allylic Substitution Strategy.
Authors: Schmidt Yvonne , Breit Bernhard
Published: February 2012

The use of the ortho‐diphenylphosphanyl benzoate as a directing group is crucial.
ChemInform Abstract: Synthesis of Novel β‐Aminocyclobutanecarboxylic Acid Derivatives by a Solvent‐Free Aza—Michael Addition and Subsequent Ring Closure.
Authors: Meiresonne Tamara , Mangelinckx Sven , De Kimpe Norbert
Published: February 2012

Halopropylidenemalonates like (I) are used as substrates for the synthesis of title derivatives (IV) via an aza‐Michael‐induced ring closure reaction.
ChemInform Abstract: Stereoselective and Diversity‐Oriented Synthesis of Trisubstituted Allylic Alcohols and Amines.
Authors: Schmidt Yvonne , Breit Bernhard
Published: February 2012

The use of the ortho‐diphenylphosphanyl benzoate as a directing group is crucial.
ChemInform Abstract: Microwave‐Assisted NBS Bromination of p‐Iminotoluenes: Preparation of New Alcohol, Mercapto, and Amino Protection Groups.
Authors: Upadhyay Sunil K. , Jursic Branko S.
Published: February 2012

Microwave‐assisted NBS mono‐ and dibromination of protected p‐aminotoluenes of type (I) in benzene gives higher yields with considerably shorter reaction times compared to performing the bromination under conventional heating.
ChemInform Abstract: Stereoselective Organocatalytic One‐Pot α,α‐Bifunctionalization of Acetaldehyde by a Tandem Mannich Reaction/Electrophilic Amination.
Authors: Coeffard Vincent , Desmarchelier Alaric , Morel Benedicte , Moreau Xavier , Greck Christine
Published: February 2012

One‐pot organocatalytic reaction of acetaldehyde (III) with N‐Bz imines (I) and azodicarboxylate (II) followed by reduction leads to syn‐2,3‐diamino alcohols with excellent enantioselectivities regardless of the substitution on the aromatic ring [cf.
ChemInform Abstract: Rhodium‐Catalyzed Intermolecular [2 + 2 + 2] Cross‐Trimerization of Aryl Ethynyl Ethers and Carbonyl Compounds to Produce Dienyl Esters.
Authors: Miyauchi Yuta , Kobayashi Masayuki , Tanaka Ken
Published: February 2012

A highly selective process is developed.
ChemInform Abstract: Expedient Synthesis of Chiral Homoallylamines via N,O‐Acetal TMS Ethers and Its Application.
Authors: Suh Young‐Ger , Jang Jaebong , Yun Hwayoung , Han Sae Mi , Shin Dongyun , Jung Jae‐Kyung , Jung Jong‐Wha
Published: February 2012

The method applies naphthylethylamine as chiral auxiliary and amine source.
ChemInform Abstract: Simple, Efficient, and Green Procedure for the Knoevenagel Condensation Catalyzed by Ethylenediammonium Diacetate under Solvent‐Free Conditions.
Authors: Zhou Zhongqiang , Sun Yong
Published: February 2012

The Knoevenagel condensation can be catalyzed by ethylenediammonium diacetate.
ChemInform Abstract: Copper(I)‐Catalyzed Regioselective Asymmetric Alkoxyamination of Aryl Enamide Derivatives.
Authors: Nakanishi Masafumi , Minard Corinne , Retailleau Pascal , Cariou Kevin , Dodd Robert H.
Published: February 2012

Both racemic and optically enriched α‐amino aminals are prepared from enamides, iminoiodane and alcohols with complete diastereoselectivities.
ChemInform Abstract: Nucleophilic ortho Allylation of Aryl and Heteroaryl Sulfoxides.
Authors: Eberhart Andrew J. , Imbriglio Jason E. , Procter David J.
Published: February 2012

Aromatic and heteroaromatic sulfoxides are allylated upon treatment with Tf2O under microwave‐assisted conditions.
ChemInform Abstract: Carbon—Sulfur Bond Formation of Challenging Substrates at Low Temperature by Using Pd‐PEPPSI‐IPent.
Authors: Sayah Mahmound , Organ Michael G.
Published: February 2012

A variety of aromatic and heteroaromatic bromides, including highly sterically congested ones, reacts with thiols to afford the corresponding thioethers with yields up to 99%.
ChemInform Abstract: N‐Bromosuccinimide Promoted One‐Pot Synthesis of Guanidine: Scope and Mechanism.
Authors: Zhou Ling , Chen Jie , Zhou Jing , Yeung Ying‐Yeung
Published: February 2012

A one‐pot procedure for the preparation of guanidine derivatives from an olefin, cyanamide, amine and NBS is developed.
ChemInform Abstract: Hiyama Cross‐Coupling of Arenediazonium Salts under Mild Reaction Conditions.
Authors: Cheng Kai , Wang Chen , Ding Yiyuan , Song Qingbao , Qi Chenze , Zhang Xian‐Man
Published: February 2012

It allows a simple and efficient access to a wide range of biaryls.
ChemInform Abstract: A Green and Highly Efficient Protocol for Catalyst‐Free Knoevenagel Condensation and Michael Addition of Aromatic Aldehydes with 1,3‐Cyclic Diketones in PEG‐400.
Authors: Firouzeh Nemati , Hossein Kiani
Published: February 2012

The reaction is conducted under environmentally benign conditions.
ChemInform Abstract: Enviro‐Economic Synthesis of Some Phthalimide Derivatives (VII) Using Microwave Irradiation.
Authors: Ameta Chetna , Ameta Rakshit , Tiwari Urvashi , Punjabi P. B. , Ameta Suresh C.
Published: February 2012

Compounds (VIIa), (VIIb) and (VIIf) exhibit moderate to strong antibacterial and antifungal activities.
ChemInform Abstract: Hypervalent Iodine‐Mediated Regioselective Cyclization of Acetylenic Malonates: Facile Synthesis of 1‐Diiodomethylene Indane and Cyclopentane Derivatives.
Authors: Zheng Chen , Fan Renhua
Published: February 2012

An intramolecular electrophilic cyclization of acetylenic malonates (I) and (III) with the combination of iodosobenzene and Bu4NI in trifluoroethanol is developed.
ChemInform Abstract: Synthesis of Novel Methanofullerenes Spiro‐Coupled with the Indolinone Fragment and Prospects of Their Use in Light‐Absorbing Layers of Plastic Solar Cells.
Authors: Romanova I. P. , et al. et al.
Published: February 2012

[The developed approach for the synthesis of methanofullerenes includes the possibility of wide variation of the substituents at the N‐atom.
ChemInform Abstract: Phase Transfer Catalyzed Asymmetric Alkylation with Epoxy Triflates as Alkylating Agents: Highly Stereoselective Synthesis of γ,δ‐Epoxy‐α‐amino Acids.
Authors: Arimitsu Satoru , Kato Daisuke , Maruoka Keiji
Published: February 2012

The use of racemic epoxide triflates gives low diastereoselectivity and enantioselectivity.
ChemInform Abstract: One‐Pot Synthesis of Chiral Aziridines by a Domino Reaction by Using Desulfonylative Formation on the N‐Tosyl Imine of Chloroacetaldehyde with an Asymmetric Mannich Reactions as a Key Step.
Authors: Hayashi Yujiro , Urushima Tatsuya , Sakamoto Daisuke , Torii Kou , Ishikawa Hayato
Published: February 2012

The reaction of (I) with aldehydes (II) leads to a dia‐ and enantioselective formation of adducts (III).
ChemInform Abstract: A Stereoselective Synthesis of Sugar‐Derived Chiral β‐Lactams.
Authors: Khangarot Rama Kanwar , Kaliappan Krishna P.
Published: February 2012

With a view to obtain potential antibiotics, the Kinugasa reaction between a variety of cyclic nitrones derived from sugars or a tartrate ester, and terminal alkynes derived from sugars provides the desired lactams (20 examples).
ChemInform Abstract: Catalytic Enantioselective Oxaziridination.
Authors: Lykke Lennart , Rodriguez‐Escrich Carles , Joergensen Karl Anker
Published: February 2012

Optically active 3‐aryl‐ or 3‐alkyl‐N‐tosyloxaziridines with exclusive trans configuration are obtained from the corresponding aldimines by oxidation with MCPBA in the presence of a cinchona alkaloid‐derived catalyst.
ChemInform Abstract: New Synthesis of Spirocycles by Utilizing in situ Forming Hypervalent Iodine Species.
Authors: Dohi Toshifumi , Nakae Tomofumi , Ishikado Yohei , Kato Daishi , Kita Yasuyuki
Published: February 2012

The high‐yielding syntheses of cyclohexadienone‐type spirocyclic compounds with varied functionalities are achieved by a new and reliable one‐pot procedure.
ChemInform Abstract: Direct Synthesis of Highly Substituted Furans from Acyloins and Active Methylene Compounds Catalyzed by Bismuth Triflate.
Authors: Komeyama Kimihiro , Ohama Yuuki , Takaki Ken
Published: February 2012

A mild and direct tandem condensation/cyclization reaction from simple and readily available starting materials using an effective catalyst is presented.
ChemInform Abstract: A New Insight into Palladium‐Catalyzed Reaction of 2‐Alkynylphenol with Carbon Monoxide.
Authors: Luo Yong , Wu Jie
Published: February 2012

A carbonylative reaction of 2‐alkynylphenols proceeds via a double insertion of triple bond and leads to the 3‐(benzofuran3‐methylene)benzofuran‐2(3H)‐ones [cf.
ChemInform Abstract: Synthesis of Functionalized Thiophenes by Four‐Component Reactions of 1,3‐Thiazolidinedione, Aromatic Aldehydes, Cyanoacetamide and Cyclic Secondary Amines.
Authors: Yao Rong , Xia Eryan , Sun Jing , Yan Chaoguo
Published: February 2012

All products are purified by recrystallization from MeCN and DMF.
ChemInform Abstract: Unusual Ligand‐Dependent Chemoselective Suzuki—Miyaura Cross‐Coupling Reactions of 3‐Bromo‐4‐trifloyl‐thiophenes.
Authors: Wang Jizhou , Seefeld Mark A. , Luengo Juan
Published: February 2012

The appropriate choice of Pd‐catalyst allows the selective reaction of the bromo‐ or the trifloyloxy substituent.
ChemInform Abstract: An Efficient Synthesis of 2‐Aminopyrroles from Enaminone—Amidine Adduct and Phenacyl/Benzyl/Heteroalkyl‐Halides.
Authors: Jalani Hitesh B. , Pandya Amit N. , Baraiya Arshi B. , Kaila Jitendra C. , Pandya Dhaivat H. , Sharma Jayesh A. , Sudarsanam V. , Vasu Kamala K.
Published: February 2012

The methodology is suitable for the generation of libraries with pyrrole scaffolds whose diverse substitution pattern allows biological screenings.
ChemInform Abstract: Artificial Metalloenzymes for Olefin Metathesis Based on the Biotin‐(strept)avidin Technology.
Authors: Lo Cheikh , Ringenberg Mark R. , Gnandt David , Wilson Yvonne , Ward Thomas R.
Published: February 2012

Incorporation of a biotinylated Hoveyda—Grubbs catalyst within (strept)avidin affords artificial metalloenzymes for the ring‐closing metathesis of diallylamine (I) in aqueous solution.
ChemInform Abstract: First Acid Catalyzed Entry to O‐Alkylated Hydroximides from Benzylic Alcohols.
Authors: Reddy Chada Raji , Radhika Laghuvarapu , Kumar Togapur Pavan , Chandrasekhar Srivari
Published: February 2012

N‐Hydroxyphthalimide and N‐hydroxysuccinimide are etherificated in the presence of a catalytic amount of TosOH to give the title products within 1h in <70% yield.
ChemInform Abstract: N‐Alkenyl Indoles as Useful Intermediates for Alkaloid Synthesis.
Authors: Li Hao , Boonnak Nawong , Padwa Albert
Published: February 2012

Cu‐catalyzed reaction of indoles with alkenyl bromides provides an effective approach to N‐alkenyl derivatives.
ChemInform Abstract: Nickel‐Catalyzed Heteroannulation of o‐Haloanilines with Alkynes.
Authors: Yoshida Yuji , Kurahashi Takuya , Matsubara Seijiro
Published: February 2012

The present reaction is sensitive towards the employed base.
ChemInform Abstract: Diastereoselective Intramolecular Friedel—Crafts Cyclizations of Substituted Methyl 2‐(1H‐Indole‐1‐carbonyl)acrylates: Efficient Access to Functionalized 1H‐Pyrrolo[1,2‐a]indoles.
Authors: Patil Dadasaheb V. , Cavitt Marchello A. , France Stafan
Published: February 2012

The reaction is applied to a wide range of indole‐derived acrylates tolerating aromatic, heteroaromatic and aliphatic substituents at the double bond.
ChemInform Abstract: One‐Pot Synthesis of Asymmetric Annulated Bis(pyrrole)s.
Authors: Smithen Deborah A. , Cameron T. Stanley , Thompson Alison
Published: February 2012

A variety of functionalized pyrrole derivatives undergoes ring annulation with acetone to afford bis‐pyrrole products [cf.
ChemInform Abstract: Electrosynthesis of Cyclic Carbonates from Epoxides and Atmospheric Pressure Carbon Dioxide.
Authors: Buckley Benjamin R. , Patel Anish P. , Wijayantha K. G. Upul
Published: February 2012

An electrochemical cell containing a copper cathode and a magnesium anode effectively converts epoxides (I) and CO2 (II) to cyclic carbonates (III) under mild conditions.
ChemInform Abstract: Gold(I)‐Catalyzed Formation of 3‐Pyrazolines Through Cycloaddition of Diaziridine to Alkynes.
Authors: Capretto David A. , Brouwer Chad , Poor Catherine B. , He Chuan
Published: February 2012

The reaction tolerates aromatic, heteroaromatic and aliphatic substituents at terminal alkynes and cannot be applied to internal alkynes.
ChemInform Abstract: Synthesis and Antimycobacterial Evaluation of 3a,4‐Dihydro‐3H‐indeno[1,2‐c]pyrazole‐2‐carboxamide Analogues.
Authors: Ahsan Mohamed Jawed , Samy Jeyabalan Govinda , Khalilullah Habibullah , Bakht Mohamed Afroz , Hassan Mohd. Zaheen
Published: February 2012

All new pyrazole‐2‐carboxamide analogues (III) show low to good antimycobacterial effects.
ChemInform Abstract: Copper(I)‐Catalyzed Three Component Reaction of Sulfonyl Azide, Alkyne, and Nitrone Cycloaddition/Rearrangement Cascades: A Novel One‐Step Synthesis of Imidazolidin‐4‐ones.
Authors: Namitharan Kayambu , Pitchumani Kasi
Published: February 2012

The reaction is catalyzed by copper(I) zeolite and allows the preparation of imidazolidin‐4‐ones with moderate diastereoselectivity.
ChemInform Abstract: Synthesis and Biological Activities of Triazole Derivatives as Inhibitors of InhA and Antituberculosis Agents.
Authors: Menendez Christophe , Gau Sylvain , Lherbet Christian , Rodriguez Frederic , Inard Cyril , Pasca Maria Rosalia , Baltas Michel
Published: February 2012

α‐Ketotriazoles (V) are obtained in a one‐pot cycloaddition reaction between ethynyl ketones (III) and azides (IV) mediated by Cu(II) without prior deprotection.
ChemInform Abstract: Unexpected C—C Bond Cleavage: Synthesis of 1,2,4‐Oxadiazol‐5‐ones from Amidoximes with Pentafluorophenyl or Trifluoromethyl Anion Acting as Leaving Group.
Authors: Gerfaud Thibaud , Wei Hai‐Long , Neuville Luc , Zhu Jieping
Published: February 2012

A novel method for the synthesis of 1,2,4‐oxadiazol‐5‐ones (III) and (VI) is elaborated using an acylation reaction of amidoximes (I) and (IV) with TFAA or pentafluorobenzoyl chloride followed by a spontaneous C—C bond breaking with the release of fluoroform or pentafluorobenzene, respectively.
ChemInform Abstract: Diels—Alder Reactions of 3‐(1H‐Tetrazol‐5‐yl)‐nitrosoalkenes: Synthesis of Functionalized 5‐(Substituted)‐1H‐tetrazoles.
Authors: Lopes Susana M. M. , Palacios Francisco , Lemos Americo , Pinho e Melo Teresa M. V. D.
Published: February 2012

Cycloaddition of in situ generated nitrosoalkene [from oxime (I)] with cyclic enol ethers, cyclopentadiene, phenoxyallene as well as electron‐rich heterocycles provides access towards oxazine (IX), (XI), (XIII), (XV), (XVII) or their regioisomeric oxime structures, e.g. (III), bearing an N‐protected tetrazole ring.
ChemInform Abstract: Highly Efficient Synthesis of 5‐Substituted 1H‐Tetrazoles Catalyzed by Cu—Zn Alloy Nanopowder, Conversion into 1,5‐ and 2,5‐Disubstituted Tetrazoles, and Synthesis and NMR Studies of New Tetrazolium Ionic Liquids.
Authors: Aridoss Gopalakrishnan , Laali Kenneth K.
Published: February 2012

Cycloaddition of a wide variety of aromatic and aliphatic nitriles with sodium azide proceeds smoothly in the presence of Cu—Zn alloy nanopowder to give 5‐substituted tetrazoles (II) and (VII) in good yields.
ChemInform Abstract: Development of a Formal Catalytic Asymmetric [4 + 2] Addition of Ethyl‐2,3‐butadienoate with Acyclic Enones.
Authors: Ashtekar Kumar Dilip , Staples Richard J. , Borhan Babak
Published: February 2012

Both enantiomers of the dihydropyrans are obtained applying alkaloid‐derived catalysts (I) or (II), respectively.
ChemInform Abstract: Tetrapropylammonium Perruthenate Catalyzed Glycol Cleavage to Carboxylic (Di)Acids.
Authors: Schmidt Andrea‐Katharina C. , Stark Christian B. W.
Published: February 2012

The reaction uses NMO as a sole oxidant and is applied to a wide range of diols leading to the carboxylic acids, bisacids and esters.
ChemInform Abstract: Bi(OTf)3‐, TfOH‐, and TMSOTf‐Mediated, One‐Pot Epoxide Rearrangement, Addition, and Intramolecular Silyl‐Modified Sakurai (ISMS) Cascade Toward Dihydropyrans: Comparison of Catalysts and Role of Bi(OTf)3.
Authors: Lambert R. Frederick , Hinkle Robert J. , Ammann Stephen E. , Lian Yajing , Liu Jia , Lewis Shane E. , Pike Robert D.
Published: February 2012

Bi(OTf)3 efficiently promotes the reaction to produce a number of cis‐substituted dihydropyrans.
ChemInform Abstract: Axial‐Selectivity in Prins Cyclization Reaction: Synthesis of 4‐Iodotetrahydropyrans.
Authors: Saikia Anil K. , Bondalapati Somasekhar , Indukuri Kiran , Gogoi Paramartha
Published: February 2012

A highly diastereoselective synthesis of the title compounds (III) and (VI) is presented.
ChemInform Abstract: Synthesis of Isochromene and Related Derivatives by Rhodium‐Catalyzed Oxidative Coupling of Benzyl and Allyl Alcohols with Alkynes.
Authors: Morimoto Keisuke , Hirano Koji , Satoh Tetsuya , Miura Masahiro
Published: February 2012

It provides a straightforward method to prepare isochromenes and related compounds.
ChemInform Abstract: Solution Phase Photocyclization Reaction of 2‐Hydroxychalcones to 4‐Flavanones.
Authors: Kamboj Ramesh C. , Berar Surinder , Berar Urmila , Gupta Satish C.
Published: February 2012

The introduced synthesis of flavanones (IV) and (VIII) is an eco‐friendly route with comparative yields to those of thermal methods.
ChemInform Abstract: Enantioselective Michael Addition of Malonates to 2‐Enoylpyridine N‐Oxides Catalyzed by Chiral Bisoxazoline—Zn(II) Complex.
Authors: Ray Sumit K. , Singh Pradeep K. , Singh Vinod K.
Published: February 2012

The reaction is general for various N‐oxides tolerating aromatic, aliphatic and alkenic substituents and affords the products with enantioselectivities up to 96% e.e.
ChemInform Abstract: Negishi Cross‐Coupling Reactions Catalyzed by an Aminophosphine‐Based Nickel System: A Reliable and General Applicable Reaction Protocol for the High‐Yielding Synthesis of Biaryls.
Authors: Gerber Roman , Frech Christian M.
Published: February 2012

A wide range of aromatic and heteroaromatic bromides reacts with biaryl zinc derivatives to provide the corresponding biaryl products.
ChemInform Abstract: Rhodium‐Catalyzed C—H Activation and Conjugate Addition under Mild Conditions.
Authors: Yang Luo , Correia Camille A. , Li Chao‐Jun
Published: February 2012

Phenylpyridine analogues (I), (IV), and (VI) smoothly react with cyclohexenone (II) to produce the corresponding conjugate addition product, regardless of the electronic nature of the substituents.
ChemInform Abstract: Synthesis and Cytotoxity of Novel Benzopyran Derivatives.
Authors: Tripathi Anil K. , Mukherjee Debaraj , Koul Surrinder , Taneja Subhash C. , Agrawal Satyam K. , Sharma Parduman R. , Saxena Ajit K.
Published: February 2012

The synthesis of hitherto unknown pyridyl‐substituted benzopyran derivatives is achieved in moderate to high yields involving the introduction of a pyridyl moiety in the benzopyran system as the key step.
ChemInform Abstract: L‐Proline Anchored Multicomponent Synthesis of Novel Pyrido[2,3‐a]carbazoles; Investigation of in vitro Antimicrobial, Antioxidant, Cytotoxicity and Structure—Activity Relationship Studies.
Authors: Indumathi T. , Ahamed V. S. Jamal , Moon Surk‐Sik , Fronczek Frank R. , Prasad K. J. Rajendra
Published: February 2012

The compounds (IV) and (VI) are tested in vitro for their antimicrobial activities against four bacteria and two fungi.
ChemInform Abstract: One‐Pot, Three‐Component Synthesis of 1,4‐Dihydropyridines in PEG‐400.
Authors: Wang Xicun , Gong Haipeng , Quan Zhengjun , Li Lei , Ye Helin
Published: February 2012

Polyethylene glycol 400 is shown to be a suitable solvent for the one‐pot condensation of aldehydes, β‐dicarbonyl compounds and ammonium acetate to give Hantzsch 1,4‐dihydropyridines of type (III).
ChemInform Abstract: A Facile Synthesis of Substituted 2‐Alkylquinolines Through [3 + 3] Annulation Between 3‐Ethoxycyclobutanones and Aromatic Amines at Room Temperature.
Authors: Shan Gang , Sun Xiuyun , Xia Qian , Rao Yu
Published: February 2012

A one‐pot method is developed for the synthesis of functionalized quinolines from easily accessible starting materials at ambient temperature.
ChemInform Abstract: Palladium(II)‐Catalyzed Dehydrogenative Alkenylation of Cyclic Enaminones via the Fujiwara—Moritani Reaction.
Authors: Yu Yi‐Yun , Niphakis Micah J. , Georg Gunda I.
Published: February 2012

A variety of nonaromatic mono‐ and bicyclic enaminones is coupled with alkenes to afford 1,3‐dienes.
ChemInform Abstract: Nickel‐Catalyzed Chelation‐Assisted Transformations Involving ortho C—H Bond Activation: Regioselective Oxidative Cycloaddition of Aromatic Amides to Alkynes.
Authors: Shiota Hirotaka , Ano Yusuke , Aihara Yoshinori , Fukumoto Yoshiya , Chatani Naoto
Published: February 2012

The new catalytic system takes advantage of the chelation assistance by the 2‐pyrididylmethylamine moiety.
ChemInform Abstract: Nickel‐Catalyzed Cycloaddition of Aromatic (O‐Benzyl)ketoximes with Alkynes to Produce Isoquinoline and Isoquinoline N‐Oxide Derivatives.
Authors: Yoshida Yuji , Kurahashi Takuya , Matsubara Seijiro
Published: February 2012

An imidamide bearing a NMe2‐group instead one of the aryls does not give the desired product.
ChemInform Abstract: Intramolecular Povarov Reactions Involving 3‐Aminocoumarins.
Authors: Kudale Amit A. , Miller David O. , Dawe Louise N. , Bodwell Graham J.
Published: February 2012

An intramolecular version of the Povarov reaction using aminocoumarins (I) and benzaldehydes bearing a pendant dienophile, is conducted under mild conditions and with high endo/exo selectivity to afford new heterocycles with a common pentacyclic core.
ChemInform Abstract: Rearrangement of Aryl‐ and Benzylthiopyridinium Imides with Participation of a Methyl Substituent.
Authors: Palko Roberta , Egyed Orsolya , Riedl Zsuzsanna , Rokob Tibor Andras , Hajos Gyoergy
Published: February 2012

Treatment of pyridinium imides of type (I) with an excess of isocyanates allows a new access to biologically important imidazopyridinones.
ChemInform Abstract: Synthesis of 1,2‐Dihydroxyindolizidines from 1‐(2‐Pyridyl)‐2‐propen‐1‐ol.
Authors: Giomi Donatella , Alfini Renzo , Micoli Alessandra , Calamai Elisa , Faggi Cristina , Brandi Alberto
Published: February 2012

Treatment of the propenol (I) with bromine followed by reduction and hydroxylation allows a facile access to 1,2‐dihydroxyindolizidines.
ChemInform Abstract: A Convenient and Efficient Protocol for the Synthesis of 4(1H)‐Cinnolones, 1,4‐Dihydrocinnolines, and Cinnolines in Aqueous Medium: Application for Detection of Nitrite Ions.
Authors: Dey Raju , Ranu Brindaban C.
Published: February 2012

Richter cyclization of o‐alkynylaniline derivatives with sodium nitrite in diluted hydrochloric acid provides an efficient access towards 4(1H)‐cinnolones (II) and (VI).
ChemInform Abstract: 1,3‐Dihydro‐2H‐indol‐2‐ones Derivatives: Design, Synthesis, in vitro Antibacterial, Antifungal and Antitubercular Study.
Authors: Akhaja Tarunkumar Nanjibhai , Raval Jignesh Priyakant
Published: February 2012

A variety of new pyrimidinylthiadiazolyliminoindolone derivatives (IX) (12 examples) is synthesized and evaluated for antimicrobial effects.
ChemInform Abstract: Green Synthesis and Antimicrobial Evaluation of Some New Trifluoromethyl‐Substituted Hexahydropyrimidine by Grinding.
Authors: Zohdi Hussein F. , Rateb Nora M. , Elnagdy Sherif M.
Published: February 2012

A simple and efficient one‐pot three‐component synthesis of the title compounds (IV) is presented.
ChemInform Abstract: Synthesis and Antiviral Activity of 2‐Aryl‐3‐(substituted‐benzalamino)‐4(3H)‐quinazolinones.
Authors: Pandey Shradha , Singh Pravin K. , Siddiqui I. R. , Singh Jagdamba
Published: February 2012

New quinazolinones (VIa) and (VIIIa) show good antiviral activities comparable to the reference drug ningnanmycin.
ChemInform Abstract: Chelation‐Assisted Palladium‐Catalyzed High Regioselective Heck Diarylation Reaction of 9‐Allyl‐9H‐purine: Synthesis of 9‐(3,3‐Diaryl‐allyl)‐9H‐purines.
Authors: Guo Hai‐Ming , Rao Wei‐Hao , Niu Hong‐Ying , Jiang Li‐Li , Liang Lei , Zhang Yang , Qu Gui‐Rong
Published: February 2012

Regioselective diarylation of 9‐allyl‐9H‐purine (I) proceeds via chelation‐assisted Heck reaction.
ChemInform Abstract: Microwave‐Assisted Pd/Cu‐Catalyzed C‐8 Direct Alkenylation of Purines and Related Azoles: An Alternative Access to 6,8,9‐Trisubstituted Purines.
Authors: Vabre Roxane , Chevot Franciane , Legraverend Michel , Piguel Sandrine
Published: February 2012

It allows an efficient access to various C‐8 alkenylated purines and related compounds.
ChemInform Abstract: Novel Procedure for the Coupling of Sterically Hindered Electron‐Deficient Anilines to the 6‐Position of the Purine Core.
Authors: Leenders Ruben , Heeres Jan , Vandenput Dirk , Guillemont Jerome , Lewi Paul
Published: February 2012

Sterically hindered, electron‐deficient anilines couple to the 6‐position of the purine core only if activated as their corresponding TFA‐amides [cf.
ChemInform Abstract: Organocatalytic Sequential Hetero‐Diels—Alder and Friedel—Crafts Reaction: Constructions of Fused Heterocycles with Scaffold Diversity.
Authors: Zhou Si‐Li , Li Jun‐Long , Dong Lin , Chen Ying‐Chun
Published: February 2012

A wide range of aliphatic aldehydes tethered to an arene motif reacts with N‐tosyl‐1‐azadiene (I) to afford three‐ to four‐cyclic products with high yields and excellent enantioselectivities and complete diastereoselectivities.
ChemInform Abstract: Copper‐Catalyzed Iminoiodane‐Mediated Aminolactonization of Olefins: Application to the Synthesis of 5,5‐Disubstituted Butyrolactones.
Authors: Karila Delphine , Leman Loic , Dodd Robert H.
Published: February 2012

Five‐ and six‐membered heterocycles such as tetrahydrofurans, tetrahydropyrans, cyclic carbamates are obtained with good yields from the starting styrene‐derived 1‐propanoates or butanoates.
ChemInform Abstract: An Efficient Synthesis of 3,3′,4,4′‐Tetrahydro‐4,4′‐bibenzo[e][1,3]oxazine‐2,2′‐dione Derivatives with the Aid of Low‐Valent Titanium.
Authors: Dou Guolan , Sun Fang , Zhao Xuan , Shi Daqing
Published: February 2012

The method features a successful reductive coupling of salicylidenephenylhydrazones and triphosgene.
ChemInform Abstract: One‐Pot, Three‐Component Synthesis of Novel δ‐Sultam Scaffolds via N‐Sulfonylation—Intramolecular Michael Sequences.
Authors: Ghandi Mehdi , Nazari Seyed Hadi , Bozcheloei Abolfazl Hasani , Sadeghazadeh Masoud , Kia Reza
Published: February 2012

One‐pot three‐component reaction of 1,3‐dicarbonyl compounds, styrenesulfonyl chlorides and amines is supposed to proceed via N‐sulfonylation—intramolecular Michael addition sequence to yield novel δ‐sultam derivatives.
ChemInform Abstract: Selective Stille Coupling Reactions of 3‐Chloro‐5‐halo(pseudohalo)‐4H‐1,2,6‐thiadiazin‐4‐ones.
Authors: Ioannidou Heraklidia A. , Kizas Christos , Koutentis Panayiotis A.
Published: February 2012

3‐Chloro‐thiadiazine triflate reacts with tributyltin arenes chemoselectively to give only the 5‐aryl‐3‐chloro‐4H‐1,2,6‐thiadiazin‐4‐ones.
ChemInform Abstract: Synthesis and Anticonvulsant Activity of Some New Thiazolo[3,2‐a][1,3]diazepine, Benzo[d]thiazolo[5,2‐a][12,6]diazepine and Benzo[d]oxazolo[5,2‐a][12,6]diazepine Analogues.
Authors: El‐Subbagh Hussein I. , Hassan Ghada S. , El‐Azab Adel S. , Abdel‐Aziz Alaa A.‐M. , Kadi Adnan A. , Al‐Obaid Abdulrahman M. , Al‐Shabanah Othman A. , Sayed‐Ahmed Mohamed M.
Published: February 2012

The compounds (IV), (V), (VII), and (IX) are screened for their anticonvulsant activity.
ChemInform Abstract: Palladium‐Catalyzed 1,4‐Addition of Diarylphosphines to α,β‐Unsaturated Aldehydes.
Authors: Chen Yun‐Rong , Duan Wei‐Liang
Published: February 2012

Pincer‐Pd catalyst (Ia) is effective in the 1,4‐addition reaction of diaryl phosphines to α,β‐unsaturated aldehydes to afford the enantioenriched phosphines with high yields and enantioselectivities [cf.
ChemInform Abstract: Azulen‐1‐yl Diazenes Substituted at C‐3 with Phenyl‐Chalcogene Moieties: Dye Synthesis, Product Characterization and Properties.
Authors: Razus Alexandru C. , Birzan Liviu , Cristea Mihaela , Dragu Eugenia Andreea , Hanganu Anamaria
Published: February 2012

A series of azulen‐1‐yl diazenes substituted at C‐3 with phenyl‐chalcogene moieties is prepared by 2 synthetic strategies.
ChemInform Abstract: Total Syntheses of Drimane‐Type Sesquiterpenoids Enabled by a Gold‐Catalyzed Tandem Reaction.
Authors: Shi Hang , Fang Lichao , Tan Ceheng , Shi Lili , Zhang Weibin , Li Chuang‐chuang , Luo Tuoping , Yang Zhen
Published: February 2012

1,7‐Diynes undergo with both internal and external nucleophiles a novel cascade transformation which involves the construction of five chemical bonds, two rings, and two stereogenic centers in a single step.