bluuebunny/crossref_metadata_2025 huggingface dataset:
Heparanase 2 Modulation Inhibits HSV-2 Replication by Regulating Heparan Sulfate
Authors: Hopkins James , Volety Ipsita , Qatanani Farreh , Shukla Deepak
Published: November 2024

The host enzyme heparanase (HPSE) facilitates the release of herpes simplex virus type 2 (HSV-2) from target cells by cleaving the viral attachment receptor heparan sulfate (HS) from infected cell surfaces. HPSE 2, an isoform of HPSE, binds to but does not possess the enzymatic activity needed to cleave cell surface HS. Our study demonstrates that HSV-2 infection significantly elevates HPSE 2 protein levels, impacting two distinct stages of viral replication. We show that higher HPSE 2 negatively affects HSV-2 replication which may be through the regulation of cell surface HS. By acting as a competitive inhibitor of HPSE, HPSE 2 may be interfering with HPSE’s interactions with HS. We demonstrate that the enhanced expression of HPSE 2, either via viral infection or plasmid transfection, reduces HPSE’s ability to cleave HS, thereby hindering viral egress. Conversely, low HPSE 2 levels achieved through siRNA transfection allow HPSE to cleave more HS, reducing viral entry. Altogether, we propose a hypothetical model in which the modulation of HPSE 2 impedes HSV-2 replication by regulating HS availability on the cell surface. This dual role of HPSE 2 in viral replication and potential tumor suppression underscores its significance in cellular processes and viral pathogenesis.
Polio Epidemiology: Strategies and Challenges for Polio Eradication Post the COVID-19 Pandemic
Authors: Bricks Lucia F. , Macina Denis , Vargas-Zambrano Juan C.
Published: November 2024

The Global Polio Eradication Initiative (GPEI), launched in 1988, has successfully reduced wild poliovirus (WPV) cases by over 99.9%, with WPV type 2 and WPV3 declared eradicated in 2015 and 2019, respectively. However, as of 2024, WPV1 remains endemic in Afghanistan and Pakistan. Since 2000, outbreaks of circulating virus derived of polio vaccines (cVDPVs) have emerged in multiple regions, primary driven by low vaccine coverage rates (VCRs). The COVID-19 pandemic disrupted routine immunization, resulting in millions of unvaccinated children, and leaving many countries vulnerable to both WPV1 and cVDPVs outbreaks. This paper reviews the epidemiological landscape of poliomyelitis post the COVID-19 pandemic, and the strategies and challenges to achieve the global polio eradication.
العوامل المؤدية لارتكاب العنف المجتمعي في المجتمع الأردني من وجهة نظر المواطنين
Authors: الدراوشة عبدالله
Published: November 2024

هدف الدراسة: هدفت الدراسة إلى تعرّف العوامل المؤدية لارتكاب العنف المجتمعي في المجتمع الأردني من وجهة نظر المواطنين في (قضاء المريغة)- محافظة معان. المنهج: لتحقيق أهداف الدراسة اعتُمد على المنهج الوصفي المسحي، وصممت وطورت استبانة لجمع البيانات، واستخدمت عينة عشوائية بسيطة أسلوباً لتحديد عينة الدراسة، وبلغت العينة (602) مبحوث. النتائج: توصلت الدراسة إلى النتائج الآتية: المستوى العام للعوامل الاجتماعية والاقتصادية والنفسية المؤدية لارتكاب العنف المجتمعي في المجتمع الأردني من وجهة نظر المواطنين في قضاء المريغة بمحافظة معان -كان بمستوى مرتفع؛ إذ بلغ المتوسط الحسابي لمحور العوامل الاجتماعية (3.81)، بانحراف معياري (0.95)، ولمحور العوامل الاقتصادية (3.75)، وانحراف معياري (0.94)، ولمحور العوامل النفسية (3.70)، وانحراف معياري (0.70). النتائج: كما أظهرت النتائج عدم وجود فروق ذات دلالة إحصائية في مستوى إجابات أفراد عينة الدراسة نحو العوامل الاجتماعية والاقتصادية والنفسية المؤدية للعنف المجتمعي باختلاف متغيرات (النوع الاجتماعي، العمر، المؤهل العلمي، الدخل الشهري، عدد أفراد الأسرة). وتوصلت الدراسة إلى مجموعة من التوصيات، أبرزها ضرورة تفعيل العقوبات واتخاذ الإجراءات القانونية بحق مرتكبي العنف المجتمعي.
Борьба за отмену ЕГЭ через призму качества российского образования
Authors: И.А. Бобкова
Published: November 2024

В работе рассмотрены некоторые аспекты борьбы противников ЕГЭ как государственной итоговой аттестации за его отмену. Внесены предложения по совершенствованию аттестации в школе.

The paper considers some aspects of the struggle of opponents of the Unified State Exam as a state final certification for its abolition. Suggestions have been made to improve the school's certification.
Место дельта-роботов в промышленности
Authors: В.В. Дубинина
Published: November 2024

В статье проведен анализ рынка дельта-роботов и их технико-экономических показателей. Рассмотрены компании-производители данного типа роботов, приведены примеры использования дельта-роботов в различных отраслях промышленности. Рассчитан технический индекс, построена его динамика и зависимость цены от него, а также взаимосвязь абсолютных показателей (радиус, масса, грузоподъемность).

The article analyzes the market for delta robots and their technical and economic indicators. Manufacturers of this type of robot are reviewed and examples of the use of delta robots in various industries are given. The technical index was calculated, its dynamics and price dependence on it were constructed, as well as the relationship of absolute indicators (reach, weight, payload).
Using Geodetic Methods in Road Construction Planning: To What Extent Will It Be Effective?
Authors: Nadzir Zulfikar Adlan , Mhd Irfansyah
Published: November 2024

Sustainable development is a well-known concept that is widely applied nowadays. One of the applications of this concept is through an effective planning process, such as road construction planning. Cut and fill volume measurement is an integral part of such a process, which utilizes several geodetic methods. The most commonly used instruments are waterpass and electronic theodolite (total station), but there are significant differences in their concepts. Different observation methods of these two tools can affect their effectiveness. Therefore, in this study, the accuracy and efficiency of waterpass and electronic theodolites were measured and analyzed using the cross-section method to gauge the effectiveness of the ABC road construction project in Sumatra. The results show that although the accuracy of the electronic theodolite is lower than that of waterpass, it might be the preferred method because it saves time and reduces the cost of volume measurement, making it both practical and highly efficient.
Ejecución presupuestaria de la Administración Pública Nacional (1995-2022): herramienta para su análisis y algunos hallazgos
Authors: Carbel Andrés
Published: November 2024

El artículo explora el accionar estatal a través de una lectura de las partidas de ejecución presupuestaria de la Administración Pública Nacional. Argumenta que estos registros ofrecen información detallada y exhaustiva sobre el gasto público, lo que permite examinar tanto elementos materiales de las políticas públicas como de organismos a su cargo. En la primera sección se presentan los supuestos teóricos que fundamentan la incorporación de datos digitales a la construcción de objetos sociales y el estudio del accionar estatal a partir de la ejecución presupuestaria. En la segunda sección se desglosa el proceso de construcción de la base de datos, para lo cual se repone las decisiones metodológicas realizadas. En la tercera parte se presentan algunos hallazgos, resultado de aplicar la herramienta en tres escalas distintas. En primer lugar, se delinean características generales del gasto nacional, con especial atención a la entrada en crisis del patrón de gasto de los últimos años; en segundo lugar, se muestra el carácter fragmentario de la inversión dentro del complejo científico-tecnológico nacional; y, en tercer lugar, se aborda un actor singular, el Ministerio Nacional de Ciencia, Tecnología e Innovación.
« Échos d’un coin du Chili » : l’Amérique latine à portée de main
Authors: Douska Ellie
Published: November 2024

Les années 1960-70 sont celles d’un véritable « moment Amérique latine » en Europe. Les images, les nouvelles et toutes les productions culturelles qui sont véhiculées à travers l’Atlantique permettent au public européen de découvrir un continent un peu oublié, de s’éprendre de ses cultures, de suivre avec intérêt les évènements qui ébranlent ses sociétés. C’est que dans un contexte marqué par la guerre froide, le sous-continent américain devient le théâtre des tensions géopolitiques et idéologiques internationales. Alors que la crainte du communisme devient une véritable obsession, les voisins du Nord ne sont pas les seuls à se mobiliser. Le Vatican se soucie également du devenir d’un continent par excellence catholique. L’actualisation de la mission traditionnelle dans une logique d’endiguement du marxisme athée se solde, en 1957, par un appel pontifical à la mobilisation des épiscopats européens en faveur des diocèses pauvres du tiers-monde. Nombreux sont les prêtres français qui y répondront et qui partiront se mettre au service des Églises d’Amérique latine. Au-delà de la mission religieuse qui leur a été confiée, leur histoire est celle d’une rencontre avec un monde et de ses défis qu’ils voudront faire découvrir au public français. L’objectif de cet article est de présenter un document inédit qui découle de cette expérience originale, un témoignage qui se veut aussi un récit édifiant et un appel à la solidarité fraternelle avec un monde victime d’injustice. Indirectement, il offre également un regard documenté du Chili des années 1960 et permet au chercheur d’aborder une période complexe sous plusieurs angles.
Perlindungan Hukum Bagi Pelaku Usaha Dalam Fitur Cash On Delivery Cek Dulu di Aplikasi Shopee
Authors: Fath Al , Brian Maulana Muhammad Syaihuputra  , Zainab Cahya Rosuli
Published: November 2024

Berkembangnya e-commerce di Indonesia mengakibatkan munculnya banyak variasi dalam pembayaran e-commerce di Indonesia. Sistem Shopee COD Cek Dulu merupakan salah satu opsi pembayaran e-commerce yang baru saja diluncurkan. Sistem pembayaran ini merupakan pembaruan dari sistem pembayaran COD yang umumnya dipakai serta menjadi salah satu opsi pembayaran di e-commerce terkemuka yaitu Shopee. Sistem COD Cek Dulu ini menimbulkan banyak persoalan yang mengakibatkan kerugian bagi para pelaku usaha. Untuk itu Indonesia sebagai negara yang menempatkan hukum sebagai landasan mengatur tiap-tiap warganya diharuskan memiliki perlindungan hukum terhadap penjual sebagai pelaku yang sering dirugikan. Tulisan ini akan membahas Perlindungan Hukum bagi Pelaku Usaha dalam Fitur Cash On Delivery Cek Dulu di Aplikasi Shopee. Adapun metode yang digunakan pendekatan Yuridis Normatif, yaitu suatu metode hukum yang dilakukan dengan meneliti bahan pustaka atau data sekunder yang berhubungan dengan perlindungan hukum terhadap penjual pada e-commerce dalam sistem pembayaran Shopee COD Cek Dulu. Dengan menggunakan landasan pada peraturan setingkat Undang-Undang yang bertujuan mewujudkan keadilan dan kemanfaatan bagi pelaku usaha di e-commerce menggunakan sistem pembayaran Shopee COD Cek Dulu.
Problematika Yuridis Praktik Pro Bono oleh Advokat: Tantangan Mewujudkan Perluasan Akses terhadap Keadilan di Indonesia
Authors: Prawira M. Rizki Yudha
Published: November 2024

Penelitian ini mencoba untuk membedah problematika yuridis pelaksanaan pemberian layanan hukum secara pro bono oleh Advokat di Indonesia. Sebagaimana telah diketahui bahwa eksistensi pro bono oleh Advokat diakui dan diatur pada Undang – Undang No. 18 Tahun 2003 Tentang Advokat, lalu pelaksanaan teknisnya diatur pada Peraturan Pemerintah No. 83 Tahun 2008 Tentang Persyaratan dan Tata Cara Pemberian Bantuan Secara Cuma – Cuma. Selain itu juga ketentuan tersebut diatur lebih spesifik melalui Peraturan Perhimpunan Advokat Indonesia Nomor 1 Tahun 2010 Tentang Petunjuk Pelaksanaan Pemberian Bantuan Hukum Secara Cuma – Cuma. Kendati demikian terdapat permasalahan pada regulasi mengenai pelaksanaan mekanisme pemberian layanan hukum secara pro bono. Pertama, praktik pro bono pada ketentuan tersebut hanya membatasi bahwa batasan pencari keadilan terbebas dari pembayaran honorarium adalah “hanya sebatas” pemberian layanan hukum saja sehingga terbuka potensi adanya biaya di luar hal tersebut seperti uang transportasi atau uang untuk makan. Kedua, mengenai cakupannya yang belum menyentuh pelaksanaan advokasi kebijakan seperti melakukan judicial review di MK. Ketiga, penerapan sanksi bagi Advokat yang melakukan pelanggaran terkait praktik pro bono. Keempat, terkait implementasi pemberian sanksi bagi Advokat yang tidak melakukan pelaporan.
Aprendizaje por Servicio y carreras STEM en educación superior: un examen bibliométrico
Authors: Verelst Nando
Published: November 2024

This article analyzes the academic production on SL in STEM formation, through a bibliometric approach, using a non-experimental and cross-sectional design, considering the last decade (2013-2022). A total of 41 articles were collected from the Scopus data base, which were analyzed using the R programming language, mainly the bibliometrix package. A significant growth in the publication of articles (11.3% in the last year), a large dispersion of authors and a high number of journals (1.3 articles per journal) were detected. Using Callon's (1991) strategic diagram, basic, motor, niche, and growing or declining themes were detected. The basic studies document SL success cases in higher education institutions, while the motor studies address the challenges of SL curricular integration, as well as its relevance for teaching sustainable development. On the other hand, there is a growing interest in integrating SL with Project-Based Learning (PBL), but there is a need to increase the number of articles that address the integration of different Active Learning Methodologies in STEM training, and their effect (individual and joint) for the achievement of formative objectives. Recommendations are provided for policymakers and researchers.
Key words: Bibliometrics, Service Learning, STEM, Higher Education.
Impulsando el Aprendizaje STEAM en las Escuelas Rurales de Chiloé. Propuesta de actividades para el desarrollo de competencias STEAM
Authors: Ferrada Ferrada Cristian Andrés , Kroff Trujillo Francisco José
Published: November 2024

The objective of this proposal is to implement the STEAM (Science, Technology, Engineering, Art and Mathematics) methodology in rural schools in the province of Chiloé. This methodology is considered an innovative and effective strategy to promote learning and the development of key competences in students. The proposal is based on the positive results of motivation and commitment that the implementation of the STEAM methodology has produced in rural educational environments. Through practical and interdisciplinary activities, it seeks to prepare students to face the challenges of the 21st century, fostering skills such as creativity, critical thinking and collaboration. The implementation of this methodology requires the support and active participation of teachers, as well as inter-institutional collaboration between different educational actors. In this way, it is expected to lay the foundations for meaningful and lasting learning, contributing to technological development and educational equity in the region. This proposal represents a valuable opportunity to enhance the integral development of students in rural schools in Chiloé, reducing educational gaps and strengthening the necessary competencies to face the challenges of the contemporary world.
Talleres de Titulación de Arquitectura Universidad de Santiago de Chile: Experiencias de Aprendizaje + Servicio
Authors: Muñoz Parra Carlos , Correa Baeriswyl María Victoria , Jiménez Cavieres Rodolfo , Saavedra Gallardo Catalina , Atria Lannefranque Jorge , Poo San Martín Luis
Published: November 2024

The development of the pedagogical methodology of Learning and Service (A+S) since the earthquake of February 27, 2010 at the USACH School of Architecture, allowed the development of experience that was transferred to the degree process of the students; it has a development of more than twelve years. In this period, it has been possible to implement relevant learning in the current career professionals in various lines of work, whether community projects, heritage interests, residence, emergencies and disasters, and health issues. This has allowed us to interact with agents from various territories of the country and thus be able to meet their requirements for projects that address their needs, expectations and hopes. These projects allowed students to visualize a work committed to a social perspective and focused on responding to specific situations in the community in the scope of their professional work.
Técnica quirúrgica se dermolipectomía post cirugía bariatrica
Authors: Meneses Rojo Pablo Andrés , Castro Araneda Iñaki , Valenzuela Silva Diego , Erazo Cortés Cristián , Benítez Seguel Susana , Albornoz Garrido Claudia
Published: November 2024

A pesar de los múltiples beneficios de la pérdida masiva de peso en pacientes obesos tras cirugía bariátrica, los pacientes suelen cursar con excedentes dermograsos significativos, generando consecuencias anatómicas, funcionales, estéticas y psicológicas que alteran su calidad de vida. En este artículo se describe una novedosa técnica quirúrgica de paniculectomía con el fin de disminuir las pérdidas hemáticas, mejorar la exposición del campo operatorio y finalmente disminuir el tiempo quirúrgico, todo con el objetivo final de evitar complicaciones postoperatorias y resguardar el bienestar del paciente. Para un adecuado abordaje se realizó la suspensión del colgajo dermograso desde en un arco rígido, facilitando la disección y se utilizó un vendaje compresivo a modo de isquemia. Enfatizamos la importancia del manejo multidisciplinario ya que las secuelas cardiovasculares y respiratorias de la obesidad deben ser evaluadas y debidamente consideradas para una evolución favorable. Presentamos esta técnica como una alternativa válida para el manejo de la flacidez cutánea y el exceso de colgajos dermograsos secundarios a la pérdida masiva de peso en pacientes postbariátricos que aún no se encuentran en condiciones de realizarse una abdominoplastía formal, permitiendo ofrecer a los pacientes un procedimiento que maneje las consecuencias postbariátricas físicas y psicológicas, manteniendo un nivel de seguridad óptimo.
Automatic segmentation of demyelination lesions in multiple sclerosis
Authors: Zakharov Alexander V. , Shirolapov Igor V. , Khivintseva Elena V. , Sergeeva Mariya S. , Romanchuk Natalya P. , Dedyk Dmitry A. , Melnikova Darya D. , Andreev Arseniy M. , Mavletova Alexandra I. , Shchepetov Anton O. , Hemanth Jude
Published: November 2024

Aim – to evaluate the effectiveness of the YOLOv8 algorithm for automatic segmentation of demyelination lesions in various locations in patients with multiple sclerosis.
Material and methods. The study included 120 patients with a clinically confirmed diagnosis of multiple sclerosis who underwent contrast-enhanced MRI. The MRI data from patients with different types of disease progression were analyzed. T1-weighted, T2-weighted, and FLAIR sequences were used for the analysis. The YOLOv8 algorithm was adapted for medical imaging and trained on manually annotated MRI scans. Model performance was evaluated using precision, recall, and F1-Score metrics.
Results. The YOLOv8 model demonstrated high segmentation performance with a precision of 0.79, recall of 00.73, and F1-Score of 0.65. The model effectively identified demyelination lesions in various locations typical for multiple sclerosis. However, there remains a need to improve recall to minimize the missed lesions. Testing on independent data confirmed the stability of the results of the model.
Conclusion. The YOLOv8 algorithm shows significant potential for automatic segmentation of demyelination lesions in multiple sclerosis patients. This method could be successfully implemented in clinical practice, enabling faster diagnosis and improved monitoring of disease progression. Further optimization of the model, through data augmentation techniques and hybrid architectures, may enhance both segmentation accuracy and recall.