bluuebunny/crossref_metadata_2025 huggingface dataset:
Relevancia del abordaje psicológico en la atención integral de la obesidad.
Authors: Domínguez Aguirre Gloria Ángela
Published: February 2020

La obesidad ha sido llamada “la Epidemia del Siglo 21” dado que está presente en todo el mundo y que vulnera de diferentes formas a quienes la padecen. En México presenta niveles sumamente altos y se considera un problema de salud pública; para su atención se han creado e implementado varias iniciativas, orientadas a atender la nutrición y la ejercitación física. Sin embargo, se requiere incluir a la psicología en ese abordaje, debido a la importancia histórica de la alimentación y por ende, de la comida. El alimento es algo vital, implica la subsistencia humana y la nutrición emocional, representa unión familiar, cuidado, amor y puede disfrazar carencias o dificultades emocionales. Las emociones influyen en la elección de alimentos y en los hábitos alimentarios. No es la emoción por sí sola, sino el modo en es afrontada lo que causa el sobrepeso.La obesidad supone un conjunto de factores genéticos o biológicos, ambientales y psicosociales, que implica una atención multidisciplinaria, en la que el abordaje psicológico puede ser un gran aliado en la promoción de hábitos saludables y en la atención de emociones, pensamientos y comportamientos. Pese al apoyo que puede brindar, la psiconutrición se considera periférica, se requiere socializar más su importancia para ser aceptada por la población vulnerable.Un tratamiento integral para la atención de la obesidad involucra atención médica, nutricional, psicológica, de ejercitación física y en su caso, quirúrgica para lograr cambios en el estilo de vida y deberá ajustarse a los principios científicos y éticos que orientan la práctica médica. El abordaje implica la valoración y el apoyo psicológico para la modificación de hábitos y conductas alimentarias; el tratamiento y el manejo de los problemas psicológicos, familiares y sociales del paciente con sobrepeso u obesidad y la referencia al nutriólogo, médico o psiquiatra, si es pertinente.
Piebaldism in To Balo, South Sulawesi: Brief Report and Literature Review
Authors: Aziz Isna Rasdianah , Muthiadin Cut , Nurfitrah Andi Nabila
Published: February 2020

Piebaldism is an autosomal dominant congenital disorder in pigment as a result of mutations in KIT gene, mapped on the long arm of chromosome 4. To Balo lived as a carrier of piebaldism genes. There are only four individuals of To Balo communities remained on Pujananting district, South Sulawesi. This study was a brief report and literature review about suspects of Piebaldism in To Balo. Data was collected by observation of depigmentation, interview and then depicted in pedigree. Phenotypic observations resulted in piebaldism on three individuals of To Balo, showed the same pattern and location of white patches. It is concluded that normal individuals could appear in third-generation when a woman or man carrier of piebaldism married with a normal individual.
Cacat Prosedur Penetapan Upah Minimum Sektoral Kabupaten/ Kota (UMSK) Gresik Jawatimur 2019
Authors: Afrilia Lidia
Published: February 2020

Permasalahan yang dikaji dalam penelitian ini mengenai perlindungan hukum terhadap pekerja maupun pengusaha terkait Penetapan Upah Minimum Sektoral (UMSK) kabupaten Gresik yang dianalisis melalui kepastian hukum tentang adanya Undang-Undang 13 tahun 2003 tentang ketenagakerjaan,  Peraturan Pemerintah nomor 78 tahun 2015 tentang Pengupahan, Peraturan Gubernur Jawa Timur No 63 tahun 2017 tentang Perubahan atas Peraturan Gubernur Jawa Timur No 52 tahun 2016 tentang Tata Cara Penetapan Upah UMP,UMK,UMSK dan Penangguhan serta Keputusan Gubernur Jatim No.188/666/KPTS/013/2018 Tentang UMSK di Jawa Timur 2019 dan Keputusan Gubernur Jatim No. 188/54/KPTS/013/2019 Tentang Perubahan Kedua atas Keputusan Gubernur Jatim No.188/666/KPTS/013/2018. Metode penelitian adalah yuridis normatif, dengan hasil kajian adalah Tahapan prosedur hukum atas penetapan UMSK telah jelas terakomodir dalam peraturan-peraturan diatas hingga peraturan teknis dan peraturan pelaksananya.
Urogynaecology Training in South East Asia (SEA) and Asia
Authors: Roy Ng Kwok Weng
Published: February 2020

South East Asia (SEA) is made up of 11 countries (Viet-nam, Laos, Cambodia, Thailand, Myanmar, Malaysia, Singapore, Brunei, Philippines, Indonesia and Timor Leste) from Myanmar in the northwest to Timor Leste in the far south east. It is one of the most far flung region in Asia, with a land mass of 4.5 million km2 and theitspopulation of 641 million makes it the third most populous geographical region in the world after South Asia and East Asia. Asia is the world’s largest most populous continent stretching from the Middle East in the west to Japan in the east with a population of 4.567 billion.
Default sequence of Mozart’s compositions during pregnancy gave higher dendritic density in the cerebrum and cerebellum of Rattus norvegicus offsprings compared with reversed sequence and control
Authors: Panjaitan Harry Mangasi Binsar , Joewono Hermanto Tri , Widjiati Widjiati
Published: February 2020

Objectives: This study aim to determine sequence of Mozart songs in the analyzing differences in dendritic density of cerebellum and cerebellum of new born Rattus novergicusMaterials and Methods: Experimental study randomized post test only control group design using Rattus norvegicus. Animal subjects were divided into three groups which were control group, and the treatment group that were given exposure to default sequence and reversed sequence of Mozart's music from gestation day 10. We used a comparison test in the analysis expression of BDNF.Results: In the cerebrum there was a significant difference in the Mozart group in reverse rather than with Mozart standard sequence and in standard Mozart group with no exposure group, with p=0.003 and p=0.000. In the cerebellum there was a significant difference in the group in reverse rather than with standard Mozart and in the standard Mozart group with the control group, with p=0.000 and p=0.000. However, there was no significant difference between control group and Mozart group upside down in cerebrum and cerebellum with p=0.109 and p=0.077Conclusion: The density of dendrites in the cerebrum and cerebellum of Rattus norvegicus newborn exposed to Mozart's music during pregnancy with standard Mozart sequence was higher than that in those receiving reverse order and without exposure. There were no significant differences between the density of the cerebrum and cerebellum dendrites between groups exposed to reversed sequence of Mozart composition and those without exposure.
Oral Presentation
Authors: Perkumpulan Obstetri dan Ginekologi Indonesia Pertemuan Ilmiah Tahunan XXIV
Published: February 2020

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Herlyn-Werner-Wunderlich Syndrome in pregnancy
Authors: Ngan Novy , Dahlan Erry Gumilar , Kurniawati Eighty Mardiyan
Published: February 2020

Objectives: To prevent Herlyn-Werner-Wunderlich syndrome’s complication in pregnancyCase Report: Presenting 2 cases pregnant with Herlyn-Werner Wunderlich syndrome, which is both of the case diagnosed at teenage and becoming pregnant then delivered by cesarean due to severe preeclampsia.Conclusion: High suspectious is needed to diagnose Herlyn-Werner-Wunderlich syndrome and early diagnosis is better prognosis. The gold standard diagnostic is MRI. The treatment is resection of the vaginal septum, drainage, and marsupialization. Preconception Counseling is important to prevent or to reduce the pregnancy complications.
Малопараметрическая аппроксимация коэффициента яркости солнечного излучения в полосе газового поглощения
Authors: Николаева Ольга Васильевна , Nikolaeva Ol'ga Vasil'evna
Published: February 2020

Рассматривается задача решения уравнения переноса солнечного излучения в атмосфере в полосе газового поглощения. Исследуется вопрос о характере спектральной зависимости коэффициента яркости излучения, отраженного системой атмосфера--подстилающая поверхность. Построены малопараметрические аппроксимации коэффициента яркости в виде разложения обратного логарифма этой величины
по степеням сечения поглощения. Рассматриваются как целые, так и дробные степени. Построенные аппроксимации являются обобщением закона Бугера-Ламберта-Бэра. Описан явный алгоритм вычисления параметров аппроксимаций по известным значениям коэффициента яркости. Показано, как построенные аппроксимации могут быть использованы для сокращения времени line-by-line расчетов коэффициента яркости.
Численное моделирование электроакустического каротажа с учетом джоулева нагрева
Authors: Плющенков Борис Данилович , Plyushchenkov Boris Danilovich , Никитин Анатолий Алексеевич , Nikitin Anatolii Alekseevich
Published: February 2020

Предложена модификация уравнений Прайда, описывающих взаимосвязанный процесс распространения акустических и электромагнитных волн в насыщенной пористой среде, возникающий в силу электрокинетического эффекта. Эта модификация позволяет принять во внимание джоулев нагрев при распространении акустических колебаний, образующихся от электромагнитного источника, и реализована с помощью добавления «термоупругих членов» в уравнения состояния для порового флюида и формации. Изменение температуры определяется уравнением теплопроводности. Изложен способ построения соответствующей конечно-разностной схемы для аксиально-симметричного случая. Представлены результаты численного моделирования, которые показали, что на низких частотах для оценки проницаемости формации можно использовать волну Стоунли, а на высоких - быструю акустическую волну, когда влиянием джоулева нагрева можно пренебречь. Однако если проводимость порового или особенно скважинного флюида достаточно высока, то из-за джоулева нагрева образуется термоупругая волна, учет вклада которой есть непростая задача из-за нелинейности эффекта.
Разрывный метод Галеркина с энтропийным ограничителем наклонов для уравнений Эйлера
Authors: Брагин Михаил Дмитриевич , Bragin Mikhail Dmitrievich , Криксин Юрий Анатольевич , Kriksin Yury Anatolievich , Тишкин Владимир Федорович , Tishkin Vladimir Fedorovich
Published: February 2020

Обобщен вариационный подход к получению уравнений энтропийно устойчивого разрывного метода Галеркина. Показано, как в данном подходе может быть учтено требование к монотонности численного решения. Применительно к уравнениям Эйлера разработан новый экономичный приближенный метод решения задачи исследуемого вариационного подхода - энтропийный ограничитель наклонов. Он гарантирует монотонность численного решения, неотрицательность давления и производства энтропии в каждом конечном элементе. Этот метод успешно протестирован на некоторых известных модельных газодинамических задачах.
Effect of bismuth substitution on magnetic properties of CoFe2O3 nanoparticles: Study of synthesize using coprecipitation method
Authors: Saputro Didik Eko , Utari Utari , Purnama Budi
Published: February 2020

Abstract: The effect of bismuth ion substitution on the magnetic properties of cobalt ferrite nanoparticles was identified in this study. This method used in this study was coprecipitation method using 0.1 bismuth ion concentration. The results on hysteresis loop showed that the saturation magnetization of cobalt ferrite nanoparticles decreased with the substitution of bismuth ions, but the coercive field experienced the opposite. Saturation magnetization decreased from 57.97 to 51.19 emu / g, while coercive fields increased from 0.64 to 0.84 kOe.
Performance of natural chlorophyll Amaranthus and Carica Papaya dye on TiO2 coating in the making of dye sensitized solar cell (DSSC) through the spin coating method
Authors: Pote Fernince Ina , Supriyanto Agus , Nurosyid Fahru , Kurniawan Deni
Published: February 2020

The natural dye extracted from Amaranthus dye and Carica Papaya dye which has been prepared in ethanol solution as a sensitizer on DSSC. The Spin coating method is used so that the deposition on TiO2 gets a homogeneous thin layer on the active area of the FTO substrate. The dye solution was tested for characterization using the Elkahfi I-V Meter and UV-Vis 1601 while the FTO structure substrate that had been prepared as a sandwich was tested using Keithley I-V type 2602A. The result of absorbance of dye is at a wavelength of 400 nm - 800 nm and there is also a shift in wavelength and peak absorption of the dye. The greatest efficiency was obtained from chlorophyll amaranthus which is 0.730% while chlorophyll Carica papaya obtained an efficiency of 0.432%. In the combination of Amaranthus dye and Carica papaya dye, the efficiency was 0.526%. High efficiency on TiO2 electrodes shows good performance on Dye-sensitized solar cells.
APPLYING DEBATE TECHNIQUE WITH REBUTTAL TYPE IN SPEAKING CLASS: PRACTICES AND IMPACTS
Authors: Vandani Intan
Published: February 2020

This study aimed at investigating the roles of debate technique with rebuttal type in a speaking class setting. It was motivated by the fact that EFL students tend to be passive in speaking activities in the classrooms. This present study applied quasi-experimental design by involving two groups of students: the experimental group and control group in which each group consisted of 35 students of a vocational high school in Malang, Indonesia.  The findings suggest that the use of debate technique with rebuttal type empowers the learning activities to be more effective and interesting. It provides the issues in the pubic area and increases the critical thinking of the students. The implications and suggestions were also discussed.

Keywords: debate technique, rebuttal type, speaking skills, critical thinking
Validasi Buku Karakter Anak Berbasis Contextual Teaching and Learning Materi Pendidikan Agama Islam dan Budi Pekerti Kelas II Sekolah Dasar
Authors: Yulianti Yulianti
Published: February 2020

Penelitian ini bertujuan untuk menghasilkan desain dan materi buku karakter anak berbasis Contextual Taching Learning  yang layak dan valid digunakan untuk mendukung pelajaran pendidikan agama Islam dan budi pekerti di Sekolah Dasar kelas II. Buku karakter yang dikembangkan ini belum ditemui di sekolah dasar karena mengintegrasikan antara materi dengan konsep CTL (contextual, teaching and learning) yang sesuai dengan karakter siswa kelas II SD, prosedur pengembangan buku karakter ini yaitu: (1) penelitian/studi pendahuluan dan pengumpulan data, (2) perencanaan, (3) pengembangan draf produk, (4) uji coba lapangan awal atau dalam penelitian ini merupakan uji validasi oleh ahli, (5) merevisi hasil uji coba lapangan awal, (6) uji coba lapangan utama atau dalam penelitian ini adalah uji coba skala kecil, (7) merevisi produk hasil uji lapangan utama, (8) uji pelaksanaan lapangan atau dalam penelitian ini adalah uji coba lapangan/ kelas, dan (9) revisi produk akhir. Instrumen yang digunakan adalah angket. Hasil dari penelitian ini untuk mengetahui kevalidan dari segi materi dan desain. Segi validasi materi diperoleh prosentase 84,5 % dan dari segi desain 86,5 %, dalam kategori sangat valid. Buku karakter ini diperlukan guna mengasah kemampuan anak sesuai usia sekolah dasar, dan untuk guru PAI dan Budi Pekerti supaya menanamkan konsep nilai agama sebagai pondasi karakter baik anak dalam setiap pembelajaran.
Pengaruh penambahan sari jamur tiram putih (Pleurotus ostreatus) terhadap kadar lemak, kadar air, kadar abu, daya mengikat air, dan nilai ph dari yogurt susu sapi
Authors: Sakul Sjaloom Ester , Rosyidi Djalal , Radiati Lilik Eka , Purwadi Purwadi
Published: February 2020

ABSTRAK

                Sari jamur tiram putih (Pleurotus ostreatus) mengandung karbohidrat yang dapat menjadi bahan penstabil alami dari  yogurt susu sapi yang berguna untuk kesehatan karena mengandung probiotik. Tujuan penelitian adalah menganalisis pengaruh penambahan sari jamur tiram putih terhadap kadar lemak, kadar air, kadar abu, daya mengikat air, dan nilai pH dari yogurt susu sapi. Rancangan percobaan menggunakan rancangan acak lengkap (RAL) dengan 4 perlakuan dan 4 ulangan, apabila terdapat pengaruh perlakuan dilanjutkan dengan uji beda nyata terkecil (BNT). Perlakuan yang ditambahkan yaitu penambahan sari jamur tiram putih (Pleurotus ostreatus) sebanyak 0% (P0), 1% (P1), 2% (P2), 3% (P3). Hasil penelitian menunjukkan kadar air, nilai pH dan kadar abu tidak terdapat perbedaan yang nyata antar  rata-rata  perlakuan (P>0.05) sedangkan kadar lemak, daya ikat air terdapat perbedaan yang nyata antar perlakuan (P<0.05). Kesimpulan dari penelitian adalah Yogurt susu sapi dengan penambahan sari jamur tiram putih sebesar 3% memiliki kualitas yang paling baik sebagai produk pangan fungsional.

 

ABSTRACT

 White oyster mushroom extract (Pleurotus ostreatus) contains carbohydrates which can be a natural stabilizer of yogurt for cow's milk which is useful for health because it contains probiotics. The purpose of the study was to analyze the effect of the addition of white oyster mushroom juice on fat content, water content, ash content, water binding power, and pH value of cow's milk yogurt. The experimental design uses a completely randomized design (CRD) with 4 treatments and 4 replications, if there is an effect of treatment followed by the smallest real difference test (BNT). The treatment added was the addition of white oyster mushroom extract (Pleurotus ostreatus) by 0% (P0), 1% (P1), 2% (P2), 3% (P3). The results showed that the water content, pH value and ash content were not significantly different between treatment averages (P> 0.05) while fat content, water binding capacity had significant differences between treatments (P <0.05). The conclusion of the study is that cow's milk yogurt with the addition of white oyster mushroom juice by 3% has the best quality as a functional food product.
Penggunaan tepung biji durian dan nangka pada berbagai level terhadap kualitas bakso daging itik petelur afkir
Authors: Rismawati Fernia , Hidayati Permata Ika , Yulianti Dyah Lestari
Published: February 2020

ABSTRAK

Penelitian ini bertujuan untuk mengetahui penggunaan tepung biji durian dan nangka pada berbagi level terhadap kualitas bakso daging itik petelur afkir. Materi yang digunakan dalam penelitian ini daging itik petelur afkir sebagai bahan dasar pembuatan bakso, tepung biji buah durian, dan tepung biji buah nangka. Metode yang digunakan adalah percobaan lapangan dengan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 4 ulangan. Perlakuan yang digunakan adalah kontrol P0 (tanpa penambahan tepung biji durian atau tepung biji nangka), dan penambahan tepung P1 (5%), P2 (10%), P3 (15%),  P4 (20%). Variabel yang diamati meliputi uji organoleptik dan daya susut masak. Hasil penelitian menunjukkan bahwa perlakuan penambahan kadar pati biji durian dan nangka pada tingkat signifikan 1% diperoleh hasil yang sangat signifikan (P<0,01) sehingga hipotesis diterima, yang berarti ada pengaruh penambahan tingkat pati. Penelitian ini menyimpulkan bahwa penggunaan tepung biji durian dan nangka 5% memiliki tingkat kesukaan tertinggi dan 20% memiliki tingkat kesukaan terendah.

Abstract

The research was aimed to test the use of durian and jackfruit seeds at various levels on the quality of duck laying duck meatballs.This research was conducted on 20 November 2016 until 20 December 2016. The method used was field experiment in a Completely Randomized Design (CRD) with 5 treatments and 4 replications. The treatment used is P0 Control (without the addition of durian seed flour or jackfruit seed flour), and addition of flour P1 (5%), P2 (10%), P3 (15%), and P4 (20%).The material used is durian seed flour, jackfruits seed flour, and laying duck laying. The observed variables include the organoleptic test and shrinking power.The results showed that treatment of the addition of seed starch level of durian and jackfruit at significant level of 1% obtained very significant results (P<0,01) so that the hypothesis is accepted, which means there is an influence on the addition of starch level. This research concluded that the use of durian and jackfruit flour 5% level has the highest level of favorite and the level of 20% has a low level of favorite.
Peningkatan Kualitas Produksi Garam Menggunakan Teknologi Geomembran
Authors: Hoiriyah Yuliana Ulfidatul
Published: February 2020

Salt is a very important commodity in daily life, both for food and industrial needs. Therefore, increasing salt production is very necessary to meet domestic salt needs. One of the most salt producing regions is Madura Island, because almost every district, especially Pamekasan, Lembung, Kec. Galis, the majority of the population work as salt farmers. The purpose of this research is to find out about improving the quality of salt production in Lembung, Kec. Pamekasan Regency, Madura, East Java Province. using Geomembrane Technology. This research is a descriptive qualitative research. The sample of this research is a resident who works as a salt farmer in the village of Lembung, Galis Regency, Pamekasan Regency, East Java, this sampling technique uses the Purposive Sampling method, data collection is done through interview session techniques, and documentation. Based on this research, it can be concluded that the increase in the quality of salt production can be done by using geomembrane technology which significantly influences the quality and quantity of production.
Pengaruh Promosi melalui Media Social Twitter pada Online Shop Shopee @SHOPEEID terhadap Keptusan Pembelian (Survei Terhadap Followers Akun Twitter @SHOPEEID)
Authors: Askaria Alda Oktitania
Published: February 2020

Pemasaran modern pada saat ini mendorong sebuah perusahaan untuk mewajibkan berkomunikasi dengan baik kepada para customernya, penyuplai, pengecer, dan pihak-pihak yang mempunyai keperluan dengan perusahaan tersebut dan juga masyarakat. Banyaknya kompetisi secara global dan banyaknya tantangan pasar mewajibkan perusahaan untuk terus berinovasi dan kreatif dalam menyusun strategi dan program-program promosi agar dapat bersaing dengan perusahaan lainnya.Salah satu strategi yang digunakan adalah promosi melalui social media twitter.Shopee adalah platform perdagangan elektronik yang menyediakan kebutuhan sehari-hari.Shopee melalui akun twitternya @ShopeeID membagikan informasi mengenai promosi-promosi yang ada yang ditawarkan kepada followers-nya.  Penelitian ini bertujuan untuk mengetahui besarnya pengaruh promosi terhadap keputusan pembelian belanja di Shopee di kalangan followers Shopee di Twitter.Penelitian ini bersifat kuantitatif yaitu dengan membagikan kuesioner dan menggunakan sampel 100 responden yang diambil dari followers twitter Shopee.  Teknik analisis data yang digunakan adalah analisis deskriptif dan regresi linier sederhana.
Increased electrical conductivity dispersion -hardened copper
Authors: Lovshenko F. G. , Khabibulin A. I.
Published: February 2020

The material, obtained in reactor, is a composition, consisting of a copper matrix of microcrystalline type with the borders of grains, stabilized by disperse particles of strengthening phases in the size of less than 20 nanometers. It is established, that the application of oxide nitrogen N2O as the technological environment at mix material processing in reactor activates the oxidationreduction transformations, which take place in mechanically alloyed compositions on the basis of system Cu–Al–CuO–MoO3, that leads to decrease in concentration of aluminium in a copper-based solid solution and, as a consequence, increases electrical conductivity of the material by 14 %, reaching values of 80 % from electrical conductivity of copper. It is shown, that the developed material is characterized by high stability against long thermal influence at the temperatures, reaching 0, 85 of temperatures of a basis fusion, which is explained by its structure.
Selection of the optimal version of the rolling rings of stand no. 7 of mill 150 of OJSC “BSW Management Company of Holding “BMC” from various types of high-speed steel, providing the best indicator of operational durability
Authors: Guzova I. A. , Kovaleva I. A. , Babkov P. A.
Published: February 2020

Rolling rings as an important element of the rolling mill belong to the category of replaceable equipment, the quality of performance of which affects a number of operational characteristics, as well as the quality of rolled products. The material from which the rolling ring of the stand No. 7 is made must have the appropriate properties capable of perceiving high thermal loads for a long period of time without destruction, chipping and significant development of calibers. In this regard, there is a need to select the optimal option for the manufacture of rolling rings that can withstand such loads for a sufficiently long period of time. The study of the causes of destruction of the rolling ring 450×242×100 mm of high-speed steel, used at OJSC «BSW – Management Company of the Holding «BMC» in the cage number 7 mill 150 rolling shop. The results of metallographic studies of the microstructure and chemical composition of fragments of the destroyed rolling ring are presented. A detailed study and comparative analysis of the chemical composition and microstructure of samples of similar rings made of high-speed steel from two different suppliers, which showed high results in durability during operation, was carried out.
Kinetics of extraction from water solutions of Fe3+, Cu2+ and Pb2+ + ions by filter loading, obtained by blinding plasters
Authors: Teran A. I.
Published: February 2020

In this study, we investigated the kinetics of extraction from aqueous solutions of Fe3+, Cu2+ and Pb2+ by filter loadings, derived from the steelmaking slags. A formal kinetic approach based on the relationship between the relative deposition rate (α) and time (τ) was used to estimate the mechanism and kinetic parameters of the deposition process). From the set of equations are selected those that in a given region of the degree of completion of the process gave the minimum value of the variance, that is, described the process in the system at this stage with the maximum probability. Three models that best correspond to real processes are selected. It was found that the deposition process at the initial stage limits the chemical stage of nucleation (formation of crystalline precipitate), then – the reaction at the interface (formation of a continuous layer of reaction products on the surface of the nuclei), and at the final stage – the growth of a continuous layer of reaction products.
Ways to improve the efficiency of Foundries of The Republic of Belarus
Authors: Vityaz P. A. , Tolstoy A. V. , Sadоkha M. A.
Published: February 2020

The ways to improve the efficiency of foundries of the Republic of Belarus are presented. The list of the basic enterprises which activity is focused on increase of knowledge intensity of a gross product, reception of a final product with high added value is resulted. Plans of loading of production capacities of the basic organizations for the period till 2030, investment projects and actions for new construction and modernization of their foundries are considered. The main provisions of the development program of foundries of the Republic of Belarus for 2017-2030, its goals and objectives are presented.
Robust Design of Suspension System with Polynomial Chaos Expansion and Machine Learning
Authors: Gao H. , Jézéque L. , Cabrol E. , Vitry B.
Published: February 2020

During the early development of a new vehicle project, the uncertainty of parameters should be taken into consideration because the design may be perturbed due to real components’ complexity and manufacturing tolerances. Thus, the numerical validation of critical suspension specifications, such as durability and ride comfort should be carried out with random factors. In this article a multi-objective optimization methodology is proposed which involves the specification’s robustness as one of the optimization objectives. To predict the output variation from a given set of uncertain-but-bounded parameters proposed by optimization iterations, an adaptive chaos polynomial expansion (PCE) is applied to combine a local design of experiments with global response surfaces. Furthermore, in order to reduce the additional tests required for PCE construction, a machine learning algorithm based on inter-design correlation matrix firstly classifies the current design points through data mining and clustering. Then it learns how to predict the robustness of future optimized solutions with no extra simulations. At the end of the optimization, a Pareto front between specifications and their robustness can be obtained which represents the best compromises among objectives. The optimum set on the front is classified and can serve as a reference for future design. An example of a quarter car model has been tested for which the target is to optimize the global durability based on real road excitations. The statistical distribution of the parameters such as the trajectories and speeds is also taken into account. The result shows the natural incompatibility between the durability of the chassis and the robustness of this durability. Here the term robustness does not mean “strength”, but means that the performance is less sensitive to perturbations. In addition, a stochastic sampling verifies the good robustness prediction of PCE method and machine learning, based on a greatly reduced number of tests. This example demonstrates the effectiveness of the approach, in particular its ability to save computational costs for full vehicle simulation.
How to Make the Charging Simple, Convenient and Efficient
Authors: Cheng W. , Wang Y.
Published: February 2020

With the large-scale application of electric vehicles (EV) in the world and also in China, the contradiction between the EV and charging stations has become more and more prominent. People always cannot easily find the charging stations or when they find them finally found they do not work. To connect the vehicle, charging station/pile and end-users for making the charging simple, convenient, efficient and visible is becoming very important. People need a platform to tell them where, when and how to charge for their EV. Matrix Mobility is focusing on realizing this comprehensive charging solution together with OEM, charging point operator (CPO), electric power company and parking lots by using big data analysis. Matrix Mobility installs the charging solution into the car unit before cars go off production line and meanwhile integrates the same function into OEM’s own APP with opening API to help end-users increase their charging experience.
Imitating a Safe Human Driver Behaviour in Roundabouts Through Deep Learning
Authors: Cervera A. S. J. , Alonso F. J. , García F. S. , Alvarez A. D.
Published: February 2020

Roundabouts provide safe and fast circulation as well as many environmental advantages, but drivers adopting unsafe behaviours while circulating through them may cause safety issues, provoking accidents. In this paper we propose a way of training an autonomous vehicle in order to behave in a human and safe way when entering a roundabout. By placing a number of cameras in our vehicle and processing their video feeds through a series of algorithms, including Machine Learning, we can build a representation of the state of the surrounding environment. Then, we use another set of Deep Learning algorithms to analyze the data and determine the safest way of circulating through a roundabout given the current state of the environment, including nearby vehicles with their estimated positions, speeds and accelerations. By watching multiple attempts of a human entering a roundabout with both safe and unsafe behaviours, our second set of algorithms can learn to mimic the human’s good attempts and act in the same way as him, which is key to a safe implementation of autonomous vehicles. This work details the series of steps that we took, from building the representation of our environment to acting according to it in order to attain safe entry into single lane roundabouts.
Natural Bridge, Virginia: Complementary Geotechnical Investigation and Analysis Methods for Mobility Planning
Authors: Bruckno Brian S. , Watts Chester F. , Stephenson George , Mau Christopher
Published: February 2020

Natural Bridge, in Rockbridge County, Virginia, is a geological arch carrying U.S. Route 11 over Cedar Creek. The area has significant historical and cultural importance; it is listed on the National Register of Historic Places and is a Virginia Historic Landmark. Until 2015, the arch and area below were privately owned and operated, with only the pavement structure of U.S. Route 11 held by the Virginia Department of Transportation. Since then, the arch and area below have been leased to the Virginia Department of Conservation and Recreation, potentially transferring liability to the Commonwealth. As part of the Commonwealth's due diligence and to help ensure that the arch is preserved for future generations, the Department of Transportation, in partnership with Radford University, completed a comprehensive, non-invasive geological and geotechnical investigation in 2017 and 2018. A complementary variety of geophysical, laser, optical, seismic, and traditional geological methods of study were used to allow for integrated data analysis. The investigation revealed potential risks to the integrity of the arch, which may eventually reduce its suitability for use as a transportation corridor. The investigation methodology allowed planning for protection of the environment, cultural resources, and local economies while avoiding any potential damage to the arch. As of the date of this article, plans are under way to relocate U.S. Route 11 onto an alternate alignment entirely, thereby helping to preserve this valuable cultural, historical, and geological asset.
Increased expression of SLC35F2 in non-small cell lung cancer predicts poor prognosis
Authors: Wei Peng , Huang Zhenjie , Liu Guangnan
Published: February 2020

Background: Although previous studies have documented the expression of Homo sapiens solute carrier family 35 member F2 (SLC35F2) in NSCLC, its prognostic value for NSCLC has not been reported.Methods: We performed Wilcoxon signed-rank test and logistic regression to investigate the correlations between SLC35F2 expression and clinical parameters. A Cox regression was used to investigate the association between clinical features and overall survival (OS). Gene Set Enrichment Analysis (GSEA) was performed to further understand the pathways involved in NSCLC pathogenesis related SLC35F2.Results: In LUAD, increased expression of SLC35F2 was associated with stage (OR = 1.53 for stage III-IV vs. Stage I-II), N stage (OR = 1.62 for N1-3 vs. N0), and residual tumor (OR = 5.00 for with tumor vs. Tumor free) (p <0.05). The Kaplan-Meier curve showed that the prognosis of SLC35F2-high NSCLC was worse than that of SLC35F2-low. For LUAD, the univariate analysis showed that increased expression of SLC35F2 was associated with a poor overall survival (HR 1.04; 95% CI 1.00-1.08; p = 0.04). Multivariate analysis showed that SLC35F2 can be used as an independent prognostic factor for LUAD. GSEA show that P53 signal pathway and apoptosis are signiﬁcantly enriched in SLC35F2-high in NSCLC.Conclusions: Increased expression of SLC35F2 in non-small cell lung cancer predicts poor prognosis. Moreover, SLC35F2 can be used as an independent prognostic factor for LUAD.
Current Evidence of Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders: A Systematic Review, Meta-analysis, and Meta-regression of Prospective Clinical Studies
Authors: Cho Woo Sup , Chung Sun Gun , Kim Won , Jo Chris H. , Lee Shi-Uk , LEE SANG-YOON
Published: February 2020

Purpose: Although several studies with animals have reported the effects of mesenchymal stem cells (MSCs) for tendon regeneration, little is known about the efficacy and safety of MSCs in human tendon disorders. We performed this meta-analysis to evaluate the efficacy and safety of MSC therapy in patients with tendon disorders enrolled in prospective clinical studies.Methods: We systematically searched prospective clinical studies investigating the effects of MSCs administration on human tendon disorders with at least a 6-month follow-up period on PubMed-Medline, Embase, and Cochrane Library databases. The primary outcome of interest was the change in pain on motion related to tendon disorders. We performed a pairwise meta-analysis using the fixed-effects model to assess treatment response, which was calculated by the standardized mean difference. Meta-regression analyses were performed to assess the relationship between MSCs dose and pooled effect sizes in each cell dose.Results: Four prospective clinical trials investigating the effect of MSCs on tendon disorders were retrieved. MSCs showed significant pooled effect size (overall Hedge’s g pooled standardized mean difference (SMD) = 1.868; 95% confidence interval [CI], 1.274–2.462; P < 0.001). The treatment with MSCs improved all the aspects analyzed, i.e. pain, functional scores, radiologic parameters (magnetic resonance image or ultrasonography), and arthroscopic findings. In the meta-regression analysis, there was a significant cell dose-dependent response in pain relief (Q = 9.06, P = 0.029). While three studies reported mild adverse events after MSCs injection, these were not severe and relieved spontaneously.Conclusions: Our meta-analysis revealed that MSC therapy may improve pain, function, radiologic, and arthroscopic parameters in patients with tendon disorders. Due to the small number of studies in this meta-analysis and considering the increasing MSCs applications, there is a strong need for large-scale randomized controlled trials to confirm the long-term functional improvement as well as the adverse effects of MSC therapies in tendon disorders.
Differential expression and bioinformatics analysis of circRNA in PDGF-BB-induced vascular smooth muscle cells
Authors: Tian Jiangtian , Fu Yahong , Li Qi , Xu Ying , Xi Xiangwen , Zheng Yuqi , Yu Li , Wang Zhuozhong , Yu Bo , Tian Jinwei
Published: February 2020

Background: Atherosclerosis is mediated by various factors and plays an important pathological foundation for cardiovascular and cerebrovascular diseases. Abnormal VSMC proliferation and migration have an essential role in atherosclerotic lesion formation. Circular RNAs have been widely detected in different species and are closely related to various diseases. However, the expression profiles and molecular regulatory mechanisms of circRNAs in VSMCs are still unknown. Methods: We used high-throughput RNA-seq as well as bioinformatics tools to systematically analyze circRNA expression profiles in samples from different VSMC phenotypes. PCR, Sanger sequencing, and qRT-PCR were performed for circRNA validation. Results: A total of 22191 circRNAs corresponding to 6273 genes (host genes) in the PS, NC or both groups, were detected, and 112 differentially expressed circRNAs were identified between the PS and NC groups, of which 59 were upregulated and 53 were downregulated. We selected 9 circRNAs for evaluation of specific head-to-tail splicing, and 10 differentially expressed circRNAs between the two groups for qRT-PCR validation. Gene Ontology and KEGG pathway enrichment analyses revealed that the parental genes of the circRNAs mainly participated in cardiac myofibril assembly and positive regulation of DNA-templated transcription, indicating that they might be involved in cardiovascular diseases. Finally, we constructed a circRNA-miRNA network based on the dysregulated circRNAs and VSMC-related miRNAs. Conclusion: The current study is the first to show the differential expression of circRNAs in PDGF-BB-induced vascular smooth muscle cells and may provide new ideas and targets for the prevention and therapy of vascular diseases.
Total laparoscopic transabdominal-transdiaphragmatic approach for treating Siewert II tumors
Authors: Pang Wei , Liu Gang , Zhang Yan , Huang Yun , Yuan Xinpu , Zhang Chaojun , Zhao Zhanwei
Published: February 2020

Background: Although the morbidity of gastric cancer has decreased, the incidence of adenocarcinoma of the esophagogastric junction (AEG) is increasing. Furthermore, no consensus exists on which surgical approach should be applied for Siewert type II AEG. The purpose of our study was to evaluate the technical safety and feasibility of a new surgical approach. Methods: Sixty patients with Siewert type II AEG underwent laparoscopic total gastrectomy with the total laparoscopic transabdominal-transdiaphragmatic (TLTT) approach, which needs an incision in the diaphragm. Results: The median operative time, reconstruction time and estimated blood loss were 214.8±41.60 mins, 29.40±7.09 mins and 209.00±110.27 ml, respectively. All of the patients had negative surgical margins. Conclusion: There were no intraoperative complications or conversions to open surgery. Our surgical procedure provides a unique option for the safe application of laparoscopic lower mediastinal lymph node dissection and gastrointestinal reconstruction. Trial Registration: Chinese Clinical Trial Registry, ChiCTR1800014336. Registered 31 December 2017- Prospectively registered, http://www.chictr.org.cn/edit.aspx?pid=23111&htm=4.
ACTH4-10 protects the ADR-injuried podocytes by stimulating B lymphocytes to secrete IL-10
Authors: Wang Kun , Du Huaping , Chen Zhen , Xue Dong
Published: February 2020

Background: In the present study, we aimed to assess whether adrenocorticotropic hormone (ACTH) could protect the podocytes from adriamycin (ADR)-induced injury by stimulating B lymphocytes to secrete the associated cytokines.Methods: The supernatant of B lymphocytes was respectively collected after B lymphocytes were intervened by phorbol myristate acetate (PMA) or ACTH4-10 (1 µg/L, 10 µg/L and 100 µg/L). Podocytes were randomly divided into the groups as follows: normal control group, adriamycin (ADR) group, the supernatant (1 µg/L, 10 µg/L, or 100 µg/L ACTH4-10)+ADR groups, ACTH4-10 (10 µg/L)+ADR group, and the supernatant (10 µg/L ACTH4-10)+anti-IL-10R+ADR group. Proliferation assay was used to assess the proliferation and activity of podocytes. Enzyme-linked immunosorbent assay was used to examine the secretion of IL-10 and IL-4. TUNEL apoptosis detection kit was used to detect podocyte apoptosis.Real-time PCR and western blotting were used to examine the mRNA and protein expression of nephrin and podocin.Results: Compared with the normal control group, the podocyte proliferation of ADR group was significantly inhibited. However, compared with the ADR group, the podocyte proliferation of the supernatant (1 µg/L, 10 µg/L or 100 µg/L ACTH4-10)+ADR groups was generally increased, and the proliferation effect of the supernatant containing 10 µg/L ACTH4-10 was the highest. Moreover, we found that after B lymphocytes were intervened by 10 µg/L ACTH4-10, the IL-10 level in the cell supernatant was significantly elevated (p <0.05). When anti-IL-10R was added, the podocyte proliferation of the supernatant (10 µg/L ACTH4-10)+ADR group was significantly inhibited. Furthermore, the supernatant of B cells stimulated with 10 µg/L ACTH4-10 could better decrease the apotosis rate of injuried podocytes and increase the mRNA and protein expression of nephrin and podocin by elevating the secretion of IL-10.Conclusions: Compared with ACTH4-10, the supernatant of B cells stimulated with ACTH4-10 could better protect the podocytes from ADR-induced injury by elevating the secretion of IL-10.
The Long-term Clinical Outcomes of Magerl's Technique Combined with Single Laminar Clamp Internal Fixation in Treatment of Reducible Atlantoaxial Dislocation
Authors: Wang Xiaoshuai , Wang Hua , Chen Guoliang , Cui Shangbin , Yu Lanzhe , Hong Dongchun , Wang Le , Pan Ximin , Sun Haixing , Liu Shaoyu , Wei Fuxin
Published: February 2020

Background. To evaluate the long⁃term clinical outcomes of Magerl's technique combined with single laminar clamp internal fixation in treatment of reducible atlantoaxial dislocation.
Methods. Data of 21 patients diagnosed with reducible atlantoaxial dislocation underwent Magerl’s technique(C1-2 posterior transarticular screw fixation) combined with single laminar clamp internal fixation and fusion were retrospectively reviewed from January 2004 to September 2015.The clinical and radiological outcomes were investigated according to the Symonand Lavender clinical standard, the score of Japanese Orthopaedic Association (JOA), and the imaging index space available for the cord (SAC), the atlas⁃dens interval (ADI), respectively. The perioperative complications, operative data, and status of bony fusion were also collected and analyzed.
Results. All the patients were followed up successfully. All the patients achieved substantially bone fusion according to the X-ray and CT scan. There were no intra-operative complications observed. The ADI was corrected significantly with the mean preoperative 6.13±1.84 mm, initial postoperative 1.62±0.77 mm, and the final follow-up 2.02±1.01 mm respectively(P<0.05).The SAC was also improved significantly with the mean preoperative 10.42±2.53 mm, initial postoperative 17.83±2.41 mm, and the final follow-up 16.91±2.02 mm respectively (P<0.05).The clinical recovery rate according to the Symonand Lavender clinical standard and the JOA recovery rate was 90.5% and 81.2% respectively, which showed significantly improved following surgery (P<0.05).
Conclusions. This study demonstrates that Magerl’s technique combined with single laminar clamp internal fixation is effective and reliable in management of reducible atlantoaxial dislocation, which can simplify the operative manipulation and decrease the risk of iatrogenic spinal cord injury.
Effects of low glycemic index and fat restriction diet on weight control and cardiovascular factors: a cohort study based on populations in Southwest China
Authors: Liu Yuping , Sun Ping , Shuai Ping , Qiao Qichuan , Li Tingxin
Published: February 2020

Background: Evidence from trials about benefits and risks of low glycemic index diets to loss weight and modify cardiovascular risk factors is preliminary. It is unclear to health benefits of choosing a suitable food source and limiting fat. The aim of this study was to prospectively assess the effect of low glycemic index and fat restriction diet on weight control and cardiovascular risk factors of overweight/obesity individuals in Southwest China.Methods: Overweight/obese men (n=101) and women (n =153) were received low glycemic index with fat restriction diet intervention, dietary advice consistent with dietary portfolio principles between February and July in 2019. Specific dietary intervention lasted 3 months. Changes in weight, body composition, and blood chemistry profile were obtained.Results: After adjusting for potential confounders, the physical indicators were significantly different at baseline and after 3-momth intervention. All detected indexes were not significantly different between the male and female individuals. Compared with baseline before intervention, participants showed varying degrees of improvement in body mass index, BMI, waist circumference, percentage of body fat, visceral fat, cholesterol and triglycerides.Conclusions: For overweight/obesity individuals in Southwest China, regardless of the gender, low glycemic index and fat restriction diet might be helpful to control weight and cardiovascular risk.Trial registration: CHiCTR, ChiCTR1900020934, Registered 22 January 2019, http://www.chictr.org.cn/edit.aspx?pid=35414&htm=4.