bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTATION EXPERIENCE OF FINE-GRAINED CONCRETE IN THE PRODUCTION OF ROAD SLABS
Authors:   Samara State Technical University, Samara city, Russia Federation, Mizuryaev S.A. , Zhakypova G.М. ,   Samara State Technical University, Samara city, Russia Federatio
Published: May 2022

An example of the implementation of fine-grained concrete in the production of fine-grained concrete products is considered in the given article. The actuality of this work is to obtain high quality material using local raw materials. The advantage of using high-strength fine-grained (sandy) concrete is that it reduces the volume of concrete (up to 50%), which reduces the mass of building structures. The reduction of construction weight reduces the cost of all materials included in the concrete (up to 50%), reinforcing steel by up to 30%. At the same time, the complexity of production, transportation costs and other additional costs will be reduced. The production composition of road slab concrete for permanent roads (class B25 coarse-grained concrete) was replaced by B60 fine-grained concrete. The usage of B60 class sand concrete for the construction of road slabs in accordance with GOST 21924.2-84 leads to an increase in their load-bearing capacit.
LIMITING EFFECT OF NETWORK RESOURCES ON VPN IMPLEMENTATION
Authors:   Kyzylorda University named after Korkyt Ata, Kyzylorda city, Republic of Kazakhstan, Tulegenova E.N. , Adranova A.B. ,   Kyzylorda University named after Korkyt Ata, Kyzylorda city, Republic of Kazakhstan, Abildakhan K.
Published: May 2022

In the modern conditions of developed information systems, the advantages of creating virtual private networks cannot be underestimated. But before mentioning the clearest and most useful ways to create virtual private networks, it is necessary to understand its meaning. Nowadays, the question of how to communicate with the corporate information system is important for users. Here they will need a broadband connection, regardless of whether they use a fixed network or Wi-Fi, as it is not uncommon for users to work on the road. Today, virtual technologies are becoming more popular, they occupy a high place in modern companies. Because they allow you to prevent the voice server from connecting to one workplace. It is not always necessary to keep employees in the office to get information about the services, there is no need to be there, it is enough to use a remote connection. Many institutions have implemented a fixed or mobile solution, which provides effective connection of mobile employees through the terminal. Many networks are now connected via the Internet. Therefore, it is necessary to take certain measures for the security of such a large system, because any computer can gain access to the network of any institution, the risk of breaking the computer is much higher without any physical effort
SYNTACTIC TERM: SUBORDINATIONAND MAIN COMPONENT
Authors:   Pavlodar Pedagogical University, Pavlodar city, Republic of Kazakhstan, Sagyndykuly B. , Boranbay B. ,   Kyzylorda University named after Korkyt Ata, Kyzylorda city, Republic of Kazakhstan
Published: May 2022

Синтаксис мәселесі әлі де болса тыңғылықты зерделеулерді қажет етеді. Мақала авторлары да осы бағытқа көңіл аудартады. Негізгі тақырып – синтаксистік терминдену. Мақалада бағыныңқы-басыңқы сипаттың сөз тіркесі синтаксисіне тән құбылыс екендігі барынша бекітілген. Сонымен қатар авторлар бұл термин сөздерді сөйлем дәрежесінде, оның ішінде құрмаластың сабақтас сөйлем дәрежесінде, көрсетілгенін дамытады. Әсіресе, құрмалас сөйлемнің көп құрамды түрлеріндегі ерекшелік басты назарға алынып, мысалдар арқылы дәлелдеуден өтеді. Авторлар «Бағыныңқы және басыңқы атауымен келетін бірліктердің қатарын санамалап беруге бола ма» деген сұрақ қоя отырып, оның жауабын іздеуде ғалымдар пікірлеріне ден қойған, қажетті жерінде олармен ұштастырып отырған. Ғылыми тұжырымдар авторлар ұсынымдарындағы ой-пікірлерді жинақтауда пайдаланылған. Және олардың дені қазақ ғалымдарының ертерек уақытта айтылған теорияларына негізделген. Мұнымен авторлар қазақы тұжырымдардың әлі де болса көкейтестілігін жоғалтпағандығын көрсеткісі келген. Авторлардың қорытындысында да нақты ұсыныстар бар. Олардың пікірінше, мәтін түзу мәселесі барынша зерделенуге түскенімен, ғылыми талдануға жарарлық тұстары бар. Мәселен, мәтін синтаксисіне тән құрылым бірліктері ішінде бағыныңқы-басыңқы сипатты талдаулар жетіспейді. Сондықтан да жас ізденушілер
A BRIEF HISTORY OF THE DEVELOPMENT OF CHINESE MYTHOLOGY
Authors:   L.N.Gumilyov Eurasian National University, Nur-Sultan city, Republic of Kazakhstan, Akhmetbek G. , Zhusupov R. ,   L.N.Gumilyov Eurasian National University, Nur-Sultan city, Republic of Kazakhstan
Published: May 2022

Chinese mythology is rich in characters invented by the boundless fantasy of the human race, there are more than a thousand of them. Mythological works are directly related to literature, therefore legends and fairy tales, where these characters appear, influenced the literature of China, and sometimes even intersect with its history.At the beginning of our era, interest in China was focused on all the unusual and strange phenomena and things that could arise as a reaction to the "dry" practice of the followers of Confucianism. Remnants of myths, folk legends and beliefs began to appear on paper. Even the titles of books of that time testify to the authors' interest in a strange and incomprehensible phenomenon: "A beautiful and amazing description", "Beautiful fairy tales", "A unique and amazing story." Some of these books were created to imitate the ancient "Book of Mountains and Seas", which is the main source of information for researchers of ancient Chinese mythology. These remarkable collections of historical records have provided researchers with a wealth of material. They also greatly influenced the development of Chinese stories, which received plots and motives from these collections. Many centuries later, in the 16th century, Xu Zhong-Lin wrote the epic novel "Ascension of the Spirits" based on myths, in which he developed the ancient imaginations of the ancients. Zhou Yu, who lived in the 17th century, tried to combine myths into epics, calling them "Legends of the creation of the world".
APPLICATION OF SOME TYPES OF INNOVATIVE TECHNOLOGIES IN GEOGRAPHY CLASSES
Authors:   Kazakh National Women's Pedagogical University, Almaty city, Republic of  Kazakhstan, Karmenova N.N. , Argingazina Sh.B. ,   Kyzylorda University named after Korkyt Ata, Kyzylorda city, Republic of Kazakhstan, Kokteubay Zh.Zh. ,   Kazakh National Women's Pedagogical University, Almaty city, Republic of  Kazakhstan
Published: May 2022

The article discusses the specifics of some types of innovative methods and the possibilities of their application in geography classes. The new image of the school and the state policy in the field of education are humanistic in nature, guided by the free development of the individual and require the creation of conditions for the implementation of these needs. Currently, among many problems, it is difficult to find ways to teach a person in combination with rapidly changing world conditions. Since humanization trends are becoming the main principles of school education, students should be ready to connect their lives with rapidly changing processes taking place in the country and in the world as a whole throughout the educational process in school. The complexity of this problem is currently at the stage of formation of educational standards in various fields of education, as well as the presence of stereotypes inherent in it in the consciousness and actions of the teacher, who considers the standard traditional. Differential learning can be considered as a tool for differentiating students based on their academic performance and as a method of unambiguous assessment of them in an individual plan. When mastering new standards, especially specific sections such as "economic and social geography of the World", teachers face difficulties, first of all, in understanding and correcting the content and semantic side of the standard. In the pedagogical and methodological literature, the question of the methodology of applying differentiated tasks in the section "economic and social geography of the world" of the school has not yet been sufficiently reflected. In conclusion, we would like to note that the poor coverage of this problem in the pedagogical literature is reflected in the practice of teaching geography in schools and explains the decrease in students ' interest in studying economic and social geography of the world. At the same time, the low level of quality of knowledge and skills is reflected. This is also confirmed by our analysis of the determining stage of an experiment conducted among students of the 10th grade in geography at school.
SELF-MOTIVATION OF PRIMARY SCHOOL STUDENTS WITH DISTANCE LEARNING
Authors:   NaberezhnyeChelny State Pedagogical University, Republic of Tatarstan, NaberezhnyeChelny, Mukhametshin A.G. , Sharafieva L.M. ,   NaberezhnyeChelny State Pedagogical University, Republic of Tatarstan, NaberezhnyeChelny, Gumerova M.M. ,   NaberezhnyeChelny State Pedagogical University, Republic of Tatarstan, NaberezhnyeChelny
Published: May 2022

Представлены результаты эмпирического исследования самоактуализации личности младшего школьника на дистанционной форме обучения. Проблематика исследования заключается в вопросе развития самоактуализации младшего школьника, так как в современной системе цифровой - рыночной экономики прежние формы классно-урочной системы обучения потеряли свою эффективность, что явилось основанием для проведения данного исследования. Цель данной работы это исследование навыков самостоятельной работы младших школьников на дистанционной форме обучения. Гипотеза исследования состоит в том, что дистанционная форма обучения при минимальном контроле со стороны учителя, будет развивать в обучающемся такие качества, как самоактуализация, самомотивация, самооценка и самокорекция. Представлена выборка, общий объём которой составил 240 ± 4 младших школьников города Набережные Челны Муниципального бюджетного образовательного учреждения «Средней общеобразовательной школы №52»: приводится расчёт коэффициента корреляционных показателей, расчёт ведётся с временной амплитудой, где используются тесты САТ самоактуализации Э. Шострома; тест уровня самомотивации С.Н.Панченко; тест проверки самооценки М.Розенберга; тест-опросник навыков самокоррекции А.В.Зверькова Е.В.Эйдмана. В результате исследования выяснилось, что навыки самоактуализирующейся личности на дистанционной форме обучения формируются по средствам самостоятельности, переносом полной ответственности на себя. Дистанционная форма обучения позволила увеличить уровень самооценки, которая приводит к чувству уверенности в себе. Оценка вклада исследования навыков самоактуализирующейся личности с минимальным надзором контролем со стороны учителей, и родителей позволит обществу по – новому взглянуть на существующую классно-урочную систему обучения, так как взгляд с иного ракурса на приобретение компетентностных навыков на дистанционной форме обучения расширит горизонты познания
Notas en torno a la transición energética y digital de la industria automotriz y la posición del sector en España
Authors: Rísquez Ramos Mario
Published: May 2022

La industria del automóvil está experimentando transformaciones profundas relacionadas con la transición hacia el vehículo electrico, conectado, autónomo y compartido. Este proceso de transición revela impactos en la arquitectura de las cadenas globales de producción del sector, en concreto, en el diseño del propio producto, en cómo se organizan los procesos productivos y logísticos y en los actores que participan en las cadenas.
El objetivo de este trabajo es ofrecer unas notas de investigacion acerca de las principales tendencias que se observan en este proceso de transformacion y plantear, aun de manera tentativa, algunas dimensiones de análisis clave para analizar la posición de la industria automotriz española en este contexto de transición.
ALTERNATIVE USE OF THE SENTMANAT EXTENSIONAL RHEOMETER TO INVESTIGATE THE RHEOLOGICAL BEHAVIOR OF INDUSTRIAL RUBBERS AT VERY LARGE DEFORMATIONS
Authors: Parisi Daniele , Coppola Salvatore , Righi Sandra , Gagliardi Giacomo , Grasso Federico Sebastiano , Bacchelli Fabio
Published: May 2022

Extensional deformations represent an effective stimulus to explore the rich rheological response of branched polymers and elastomers, enabling the design of polymers with specific molecular structure. However, probing the polymer behavior at large deformations is often limited by the experimental devices. We here present an alternative use of the Sentmanat Extensional Rheometer (SER) that allows Hencky strain units much larger than the maximum value achievable, ∼3.6. The proposed procedure consists of an oblique positioning of the sample in the measuring area. If a small inclination of the sample is used, the departure from the ideal uniaxial flow is negligible at Hencky strains <1, and nearly zero for larger values. Experimental results in the linear viscoelastic regime are compared with the double reptation model in order to discern polydispersity and branching effects, whereas the extensional rheology data are contrasted with the molecular stress function theory (MSF), revealing important information about the polymer structure, especially on the long-chain branching (LCB). Finally, the analysis of sample failure upon elongation allowed us to correlate the polymer structure to the rheological behavior during mixing processes.
Blood loss and transfusion rates following total hip arthroplasty: a multivariate analysis
Authors: Patil Amogh , Sephton Benjamin Michael , Ashdown Thomas , Bakhshayesh Peyman
Published: May 2022

This study aimed to identify factors that inde- pendently predict increased rates of transfusion following total hip arthroplasty (THA) surgery. A retrospective analysis of all patients undergoing THA surgery over 12 months was performed. Electronic operative records were analysed to determine the following patient factors: American Society of Anesthesiologists (ASA) grade, body mass index (BMI), co-morbidities, indication for surgery, surgical technique, type of implant used, haematological markers, hospital length of stay (LOS) and complications. A total of 244 patients were included. There were 141 females (58%) and 103 males (42%). The median age was 65±12. The median pre-operative blood volume was 4500mls (IQR; 4000-5200). The median blood loss was 1069mls (IQR; 775-1390). The total number of patients requiring transfusion was 28 (11%), with a median of two units being transfused. Pre-operative haemoglobin (p<0.001) level, haematocrit (p<0.001) level and weight (p=0.016) were found to be predictive of transfusion requirement as well as ASA grade (p=0.005). Application of an intra-operative surgical drain was associated with higher rates of transfusion (p<0.001). Our study strengthens the evidence that pre-operative haemoglobin and haematocrit levels are valuable predictors of patients requiring transfusion. Additionally, ASA grade may be viewed as a helpful factor in predicting risk of transfusion. A strategy incorporating pre-operative optimisation of modifiable factors may reduce rates of transfusion requirement.
Adverse local tissue reaction after ceramic-on-ceramic total hip arthroplasty
Authors: Valcarenghi Jérôme , Poinot Nicolas , Verstraeten Pierre-Bernard , Chahidi Esfandiar , Caufriez Benoit , Costenoble Vincent , Collard Xavier
Published: May 2022

We report a rare case of symptomatic adverse local tissue reaction in a patient with a ceramic-on-ceramic total hip bearing surface and review the literature. Probably, ceramic wear debris is not entirely inert and may lead to adverse local tissue reactions.
Comparative studies of physico-chemical parameters and Total Hydrocarbon Content (THC) of Choba and Iwofe axis of the New Calabar River in the Niger Delta, Nigeria.
Authors: Beauty Happiness Wosu  , Miebaka Moslen  , Calista Adamma Miebaka
Published: May 2022

Monitoring physicochemical parameters is important in water quality management. This study examined some physicochemical parameters of the Choba and Iwofe axis of the New Calabar River in the Niger Delta relative to anthropogenic activities in the area. Both in situ and laboratory analysis of the water samples were done. Data analysis was also done using the SPSS version 25 and results compared with regulatory standards. Temperature was highest at Iwofe (stn. 4), 28.24 oC; Choba (stn. 1) was more acidic, pH 5.57; stations at Iwofe had highest electrical conductivity with a value of 613.68 µS/cm; nitrate was above permissible limits across the study area, with an average value of 15.83 mg/l; sulphate was below permissible limits across stations, with an average value of 19.24 mg/l; Iwofe (stn. 3) was the most turbid, with a value of 62.7 NTU; chloride was below permissible limits, with an average value of 47.88 mg/l; phosphate exceeded permissible limits, with an average value of 2.35 mg/l; while THC values at three stations had an average of 0.9 mg/l. The result showed a statistically significant difference in temperature, Conductivity, turbidity, nitrate and sulphate across the study area (p<0.05) while values of pH, chloride and phosphate did not differ significantly (p>0.05) between the stations examined. The study concluded that there was an imbalance in the levels of physicochemical parameters of the water bodies studied when compared with regulatory limits of WHO. These inconsistences were attributed to the introduction of extraneous materials into the water bodies due to human activities, emphasizing the need for proper waste management practices in these areas.
正念融入青少年三級輔導模式之探討
Authors: 廖偉舟 廖偉舟
Published: May 2022

本文探討如何將正念的實證效益結合學校的三級輔導模式以提供青少年心理方面的協助。正念發展至今已有二三十年，應用在醫學、教育、生活等各層面已相當廣泛，亦無年齡層的差別，服務的對象從嚴重的精神疾患到輕微的心理障礙都有顯著的效果，甚至也提供一般人心理保健之道，也因服務對象需求之不同而發展出各種不同的療癒方案或教育課程。筆者認為正念的發展正好與學校三級輔導模式的分層分工相互呼應，不僅同樣關注心理層面的健康，也強調滿足各級學生的不同需求。青少年正值身心劇烈變化的時期，對自我產生很多的好奇與疑惑、擔心與不安，開始面對各種人際困擾，需要環境給予較多的關懷與協助，正念恰可提供青少年相當多的助益；也由於青少年正值國民教育階段，藉由學校正念環境的建構將可協助所有的青少年。儘管目前正念已逐漸在學校發展起來，但是尚沒有清楚的架構依循可以視人適需提供合宜的正念處置方式，因此筆者擬以三級輔導為架構探討如何將正念有效地應用在青少年對象上，冀望能夠協助他們度過風暴的青春期。

 

This article explored how to combine the empirical benefits of mindfulness with the school’s three-level counseling model to provide psychological assistance for adolescents. Mindfulness has been developed for 20 to 30 years, and it has been widely used in medicine, education, and life. There is no difference in age groups. Moreover, mindfulness can be beneficial to people of all ages. Mindfulness has a significant effect on its target groups, ranging from severe mental illness to mild psychological disorders, and it’s even provided with the public general with mental health care. Various treatments have been developed due to the different needs of target groups, including healing programs and educational courses. The author believes that the development of mindfulness synergistically interacts with the hierarchical division of labor in the school’s three-level guidance model. It not only pays attention to psychological health but also emphasizes meeting the different needs of students at all levels. Teenagers are in a period of drastic physical and mental changes. They have a lot of curiosity, doubts, worry and anxiety about themselves, and they also begin to face various interpersonal problems. They need more care and assistance from the environment. Mindfulness can provide a lot of help for adolescents. What’s more, since adolescents are at the stage of national education, all adolescents can be assisted by the construction of a mindfulness environment in schools. Although mindfulness has gradually developed in schools, there is still no clear framework to follow to provide appropriate mindfulness treatment methods according to people’s needs. Therefore, the author intends to use a three-level counseling framework to explore how to effectively apply mindfulness to young people and help them weather the ups and downs of their adolescent period.

 
دراسة تأثير كوفيد-19 على الصحة النفسية في سوريا مقارنة بعينة من البلاد العربية: دراسة متغيرات مستوى القلق قبل اندلاع جائحة كوفيد-19 وفي ظل وجودها
Authors: صوفان باسل عبدالهادي , بيرقدار باسل عمر , صوفان ، اياد عبدالهادي
Published: May 2022

الملخص

الخلفية: لم تكتفِ جائحة كوفيد-19 بحصد أرواح بعض المرضى بل أدت أيضًا إلى عزلة وحجر أفراد المجتمع وتوقف العديد من الأعمال والأنشطة الترفيهية والدينية التي تعد من المغذيات الروحية للصحة النفسية واضعةً بصمتها وملحقةً الأذى بها. الهدف: هدفت الدراسة لمقارنة مستويات القلق قبل وبعد وجود الجائحة في سوريا، ومقارنتها مع بعض البلدان العربية الأخرى، إضافةً لدراسة انعكاس الصحة النفسية على الصحة الجسدية بعد انتشار المرض بدراسة ثلاثة متغيرات: النوع، العمر، المهنة. الأدوات: استخدم الباحثون في الدراسة استبيان الكتروني قسمه الأساسي مقياس هاميلتون لتقييم القلق، وتضمن أيضًا بعض المعلومات الديموغرافية للمشاركين، وحُللت البيانات باستخدام لغة بايثون البرمجية. النتائج: تضمنت العينة 559 مستجيبًا من عدد من البلاد العربيّة (53.31% مقيمون في سوريا، 62.79% إناث، 53.31% أعمارهم 21-30 عام). أظهرت الدراسة بأن مستويات القلق ارتفعت عمومًا في ظل وجود الجائحة، إذ ارتفع متوسط الدرجة الكلية لمقياس هاميلتون بمقدار 5.50 نقطة في سوريا وبمقدار 4.60 في بعض البلدان العربية الأخرى مع عدم وجود فرق إحصائي هام P>0.05))، وتعد الإناث الأصغر من 31 عامًا الفئة الأكثر تضررًا. الاستنتاج: تقترح الدراسة زيادة توارد المرضى إلى العيادات النفسية والهضمية وتأثُّر العملية التعليمية والمهنية سلبًا بسبب ازدياد معدل القلق والأرق خاصة لدى الشبّان والإناث. وتوصي بتنظيم جلسات نفسية داعمة في المدارس والجامعات وأماكن العمل، وتقديم الدعم النفسي للأفراد عامة وللفئات المذكورة خاصة.
Analysis of stress, coping strategies and happiness of urban and rural students during COVID-19 pandemic
Authors: Kumar Sanjeev , Mazumdar Indu , Choudhary Swati , Dhull Sandeep
Published: May 2022

The present study aimed to analyze the Stress, Coping Strategies and Happiness of Urban and Rural Students During Covid-19 Pandemic. A sample of one hundred thirty postgraduate students was the subject for the study. Subjects were randomly selected from science departments Central University of Punjab, Bathinda, India. The Brief-COPE (Carver, 1997) 28 item self-report questionnaire assessed effective and ineffective ways to cope with a stressful life event. The DASS-21 developed by (Lovibond and Lovibond, 1995) evaluated recent experiences of stress, anxiety and depression. The Oxford Happiness Questionnaire (Michael Argyle and Peter Hills, 2002) assessed happiness. The data were analysed using the SPSS -21 versions. The 2 X 2 Factorial MANOVA was applied for analyzing the scores of coping strategies and Stressful life and the multivariate effect of between subject factor (gender) is insignificant irrespective of age groups, Wilk’s λ=0.98, F (4,123) = 0.58, p>=0.05, multivariate η2= 02. Multivariate effect of within -subject factor (Location) is significant irrespective of gender groups, Wilk’s λ=0.90, F (4,123) = 3.47, p<=0.05, multivariate η2= 10. There is no significant multivariate effect across the interaction between the gender and location, Wilk’s λ=0.95, F (4,123) = 1.67, p>=0.05, multivariate η2= 05.
Assessment of impact of orthognathic surgery on quality of life in patients with dentofacial defects
Authors: Sinha Abhishek , Choudhary Shivendra , Shankar Daya , Taruna Taruna , Priya Leena
Published: May 2022

Background: Dentofacial deformities have a major negative social impact because of its association with esthetic and functional limitations. The present study was conducted to assess the impact of orthognathic surgery on quality of life in patients with dentofacial defects. Materials & Methods: 52 patients undergoing dental surgery to correct dentofacial deformities of both genders were included. Group I comprised of cases and group II control subjects.  Deformities were grouped for analysis into DEF. 0, DEF. 1, DEF. 2, DEF. 3 and DEF. 4 (Other Deformities). OHIP-14 was completed in three stages: 1 week before surgery (T0), 1 month following surgery (T1), and 3 months following surgery (T2). The response recorded was never (0), rarely (1), sometimes (2), often (3), and always (4). Results: Out of 52 patients, males were 32 and females were 20. OHIP- 14 score 19 at T0, 22 at T1, 7 at T2, 3 at T1-T0, -12 at T2-T0 and -15 at T2-T1. The difference was significant (P< 0.05).
Lomitapide en hipercolesterolemia familiar heterocigota: reporte de caso
Authors: Bedoya Loaiza Juan Esteban , Flórez Romero Andrés , Hurtado Amézquita Yesid Camilo
Published: May 2022

El hipercolesterolemia familiar (HF) es una enfermedad autosómica dominante causada por mutaciones del gen que codifica para el receptor de colesterol de baja densidad (LDLR) o en moléculas asociadas al funcionamiento de éste (1). La forma heterocigota (HFHe) se presenta con una prevalencia de 1 por cada 200 a 300 personas (2), con elevaciones de colesterol de baja densidad (cLDL) entre 160 a 580 mg/dL y aumento del riesgo de enfermedad cardiovascular temprana (5). Para el diagnóstico se precisa de la realización de escalas de puntuación como la del Simon Broome o Dutch Lipid Clinic Network y la confirmación a través de pruebas de diagnóstico genético (5). La modificación al estilo de vida y las estatinas son la terapia de primera línea (7), sin embargo, es frecuente que no se alcance la meta de reducción de cLDL o se presente intolerancia farmacológica, en estos casos se recomienda el uso de inhibidores de la proproteína convertasa subtilisina-kexina tipo 9 (PCSK9) (13,14). Presentamos el caso de una mujer de 68 años de edad con HFHe que presentó intolerancia a estatinas y no respondió a inhibidores de la PCSK9, por lo que se inició lomitapide, con reducción del 50% del cLDL y adecuada tolerancia. Este medicamento está aprobado para el tratamiento de la hipercolesterolemia familiar homocigota (HFHo) (15).
Enfoque del adulto con Disgenesia gonadal mixta: a propósito de un caso
Authors: Agudelo Zapata Yessica
Published: May 2022

Este artículo presenta el caso de un paciente de 32 años con ambigüedad sexual desde el nacimiento. Durante la infancia no fue intervenido quirúrgicamente y no tuvo ningún tipo de seguimiento en el tiempo. El paciente ya adulto se identifica con género masculino, tiene hipogonadismo hipergonadotrófo y un cariotipo 45,X/46,XY que hace diagnóstico de disgenesia gonadal mixta. En este artículo se discute su enfoque, seguimiento y manejo multidisciplinario apropiado para evitar complicaciones. También se resalta la importancia de la autonomía del paciente y la individualización del tratamiento.
Perancangan Prototype Sistem Informasi Repository Skripsi Berbasis Web Di UNA’IM Yapis Wamena Papua
Authors: Syarifah  , Chairullah Naury  , Wahyuni Nurindah Sulistiyowati
Published: May 2022

In Indonesia, there are many institutions that use information systems in the field of education, one of which is the Repository information system. Repository is a digital-based library term where this information system can be used to access student thesis, both the academic community and academics outside the campus as reference material for writing scientific papers. Even so, not all colleges use it. One of them is Amal Ilmiah Yapis Wamena University. As a university located in conflict and mountainous areas, data loss often occurs. Likewise with the use of information systems that have not been maximized. This study aims to design a prototype of a web-based thesis repository information system at the Amal Ilmiah Yapis Wamena University. The method used is simulated prototyping. The results of this study show the prototype/prototype design in the form of a web-based thesis repository information system mockup as many as 7 (seven) mockup pages, including the login page, lecturer list, Lecturer data entry form, student list, student data entry form, repository list, and form. repository data entry.
Komparasi Kinerja Integrated Development Environment (IDE) Dalam Mengeksekusi Perintah Python
Authors: Ismail Setiawan
Published: May 2022

An IDE is basically a software package consisting of tools used to develop and test software. IDEs help automate developer tasks by reducing manual effort and combining all tools in a common framework. If the IDE does not exist, then the developer will have to do the selection, integration, and deployment process manually. This study tries to compare the performance of ideas in recognizing writing errors or the simplest syntax in the python language, namely indentation. The test results of the 6 IDEs used found 1 IDE that managed to detect syntax writing errors, namely w3schools. The choice lies with the developer. Generally, the idea is used for programs such as compiled languages such as C, C++, Java, .NET. While the code editor is used for scripts and interpreted, such as PHP, JavaScript, Python, Ruby. In terms of features, of course, using an IDE is more complete than a text editor. If the developer uses VS code, the environment can be adjusted like a code editor but still carries the reliability of an IDE.
A produção intelectual sobre fotografia na área da Ciência da Informação: perspectivas bibliométricas com a Web of Science
Authors: Cirillo Aparecido José , Nascimento Lucileide Andrade de Lima do , Miguel Marcelo Calderari , Costa Rosa da Penha Ferreira da
Published: May 2022

A pesquisa situa alguns indicadores sobre a produção acadêmica, periódicos e pesquisadores mais envolvidos com o tema fotografia na categoria tecnologia via preceitos bibliométricos. Realiza diagnóstico na coleção principal da Web of Science e recupera fontes documentais na área tecnologia, indexadas de 2001 a 2020. Demostra nos resultados o notório crescimento do tema fotografia – ao que parece devido ao aumento e qualificação dos programas de pós-graduação e das dinâmicas e reflexos, simbólicas e imagéticas, da influência das redes sociovirtuais na infoera.
Imaginário e fotojornalismo em Gaúchazh: como a relação dos indivíduos com os espaços se modifica no contexto pandêmico
Authors: Negrini Michele , Dias Bibiana de Moraes
Published: May 2022

A pandemia do novo coronavírus, o COVID-19, é um tema que tem pautado, de forma intensa, os meios de comunicação na atualidade. Desta forma, o objetivo deste artigo é analisar a fotorreportagem “O impacto do coronavírus na rotina do RS”, publicada no GaúchaZH, a fim de entender, através da imprensa brasileira, como se dá a relação simbólica entre os indivíduos e os espaços em tempos de pandemia e isolamento social. Realizamos uma pesquisa exploratória, com método observacional (GIL, 2008). Para fins de análise, inicialmente dispensamos olhares para perspectivas históricas do portal e, posteriormente, foi feita uma observação do avançar do isolamento através de cinco fotografias selecionadas da publicação em questão. Tomamos como base para reflexões a teoria do imaginário.
Survival of Patients With Primary Osseous Malignancies of the Mobile Spine Is Associated With Access to “Standard Treatment” Protocols
Authors: Stroud Sarah G. , Geiger Erik J. , Lichtensztajn Daphne Y. , Goldsby Robert E. , Cheng Iona , Wustrack Rosanna , Theologis Alekos A.
Published: May 2022

Introduction:

Malignancies of the mobile spine carry high morbidity and mortality. This study sought to examine factors associated with receipt of “standard” treatment and survival for patients with primary mobile spine tumors in the California Cancer Registry (CCR).

Methods:

The CCR (1988 to 2016) data were obtained for patients with primary tumors of the mobile spine and at least 1-year follow-up. Sacrum/pelvis tumors were excluded. Age at diagnosis, sex, race, neighborhood socioeconomic status, insurance, Charlson Comorbidity Index, histologic diagnosis, stage at diagnosis, and treatment at a National Cancer Institute-designated Cancer Center (NCICC) were collected. Multivariate analyses were done to identify factors associated with all-cause mortality and receipt of “standard” treatment.

Results:

Four hundred eighty-four patients (64% White, 56% low neighborhood socioeconomic status, and 36% privately insured) were included. Chordoma (37%) was the most common diagnosis. Only 16% had metastatic disease at presentation. Only 29% received treatment at an NCICC. Lower age, Charlson Comorbidity Index, less extensive stage of disease, and private insurance were associated with lower all-cause mortality (all P < 0.05). Medicaid/public insurance (hazard ratio [HR], 1.65; 95% confidence interval [CI], 1.13 to 2.41) and Medicare (HR, 1.80; 95% CI, 1.25 to 2.59) were associated with higher mortality compared with private insurance. Patients who received no known treatment (HR, 2.41; CI, 1.51 to 3.84) or treatment other than the “standard” (HR, 1.45; CI, 1.11 to 1.91) had higher mortality compared with those who received the standard protocols. A critical predictor of receiving the standard treatment protocol was being treated at an NCICC. If patients did not receive care at such institutions, they received optimal treatment only 40% of the time (HR, 0.5; P = 0.004).

Conclusions:

Receipt of defined “standard treatment” protocols was associated with care received at an NCICC and lower all-cause mortality in patients with primary osseous malignancies of the mobile spine. Patients with public insurance are vulnerable to worse outcomes, regardless of age, disease burden, or receipt of standard treatment.

Level of evidence:

III
Expansion and spread of the Jalalist movement in Azerbaijanat the end of the XVI century
Authors:   Western Caspian University, Karbalayeva Amana
Published: May 2022

At the end of the 16th century the protracted wars of the Ottoman Empire with European states and the Safavids worsened the situation of the people, led to an economic crisis, an increase in market prices, higher taxes, arbitrariness of officials. As most of these events took place in Eastern Anatolia, both sides (the Ottoman court and the Safavid government) intended to use Jalali's help in their struggle. However, the analysis of these events shows that since the historical lands of Eastern Anatolia are Azerbaijani lands, these events provide ample reason to assess Azerbaijan as the main centre of the Jalali movement.The socio-economic situation in the society created conditions for the expansion of the Jalali movement. In such a situation not only representatives of the working masses but also disgruntled landowners, sipai, and sometimes even provincial leaders joined the Jalala movement. Therefore, while the "Jalali movement" was a movement against the crisis and arbitrariness in the palace, government circles and among the people, on the other hand it was joined by forces engaged in plundering and arbitrariness. The renewed warfare of Shah Abbas I against the Ottomans at the beginning of the 17th century helped the movement to spread in Azerbaijan. During the war against the Ottomans some Jalali groups took part in the liberation of Azerbaijani lands from the Ottoman occupation, as Shah Abbas I officially incorporated the leaders of various groups involved in the Jalali movement into the Safavid army of Gizilbash.
Konflik Muslim Madura Vs Dayak Di Sampit Serta Diskursus Kaharingan Sebagai Klaim Agama
Authors: Sholeh Muhyiddin
Published: May 2022

Tulisan ini bertujuan menjelaskan dinamika konflik muslim Madura dengan orang Dayak di Sampit serta menjelaskan klaim Kaharingan sebagai agama. Orang Madura yang mayoritas beragama Islam serta orang Dayak yang menganut system kepercayaan Kaharingan menjadi poros perhatian dalam tulisan ini. Dalam perjalanannya, Kaharingan sebagai system kepercayaan orang Dayak telah mendarah daging kemudian muncul tuntutan penglegalan Kaharingan sebagai agama resmi yang di akui Negara. Metode yang digunakan dalam penelitian ini adalah deskriptif analitik dengan pendekatan kajian literatur. Hasil kajian menunjukkan bahwa, Pertama: konflik Muslim Madura vs Dayak disebabkan banyak faktor. Diantara nya adalah faktor ekonomi, etnis, sosial, dan agama. Kedua, Pengaruh signifikan konflik Sampit terhadap tuntutan penglegalan Kaharingan sebagai agama.
Konseling Abangan Perspektif Psikoterapi Islam
Authors: Istiqomah Fiqoini , Subahri Bambang
Published: May 2022

Clifford Geertz dikenal dengan teori trikotominya, yakni abangan, santri, dan priyayi dalam masyarakat Jawa. Salah satu budaya Jawa dalam buku Agama Jawa karya Geertz adalah praktik pengobatan, praktik ini dilakukan oleh praktisi khusus yang dikenal sebagai dukun, yang identik dengan masyarakat Jawa varian abangan. Dalam praktiknya, dukun menerapkan asas-asas dan fungsi bimbingan dan konseling, praktik ini kemudian disebut sebagai konseling abangan. Pengobatan ini tidak hanya mengobati penyakit fisik yang nampak saja, melainkan juga mengobati penyakit psikis yang tidak nampak. Praktik ini perlu ditinjau menggunakan kacamata psikoterapi Islam. Ada pun teori yang digunakan dalam penelitian ini adalah psikoterapi Islam milik Abu Zaid al-Balkhi tentang kesehatan jiwa Islam. Berbeda dengan teori psikoterapi Islam milik ilmuwan lain seperti ar-Razi, al-Ghazali, dan Ibnu Sina yang lebih fokus kepada penggolongan jiwa manusia dan tingkatannya, konsentrasi bahasan al-Balkhi adalah kontruksi manusia yang terdiri dari jasmani dan rohani. Dimana hal ini sangat relevan dengan praktik konseling abangan. Penelitian ini berfokus pada bagaimana praktik konseling abangan dalam buku Agama Jawa, serta bagaimana pandangan psikoterapi Islam terhadapnya. Penelitian ini menggunakan pendekatan kualitatif, karena menekankan pada penafsiran data yang ditunjukkan dalam bentuk deskripsi. Sementara jenis penelitan ini termasuk kepada studi pustaka, karena data yang dianalisis berupa sumber tertulis, yakni buku Agama Jawa karya Clifford Geertz.
Intriguing Images/Cases: Alphabet Opacity (Sutural Cataract)
Authors:   Deptt. of Ophthalmology, Shri Lal Bahadur Shastri Government Medical College and Hospital, Nerchowk, Distt. Mandi, Himachal Pradesh, India, Chauhan Anubhav , Sharma Deepak Kumar ,   Deptt. of Ophthalmology, Shri Lal Bahadur Shastri Government Medical College and Hospital, Nerchowk, Distt. Mandi, Himachal Pradesh, India
Published: May 2022

We report an accidental finding of a classic Y shaped sutural(congenital) cataract in a 15-year-old female who came for routine ocular checkup.
The Evaluation After the Zones of Laboratorial Diagnosis
Authors:   Health Human International Environment Foundation, Budapest, Hungary, Vincze Janos , Vincze-Tiszay Gabriella
Published: May 2022

During our ontogenetic development, the reference system of temporalisation is given by the synchronisation of the biophysical, biochemical and physiological needs and of the body movements. This is ruined by the requirement of minute and second accuracy of social adaptation, to which the inner biological clock of the human being is unable to synchronise. The functional scheme of the block-scheme is made of functional blocks which represent system elements or devices, which fulfil certain functions. In the schemes, the functional blocks are denoted with rectangles, bearing their names according to the functions fulfilled. In case of living systems the negative feedback regulation known from cybernetics is available only in the optimal range, as the other ranges are asymmetrical and due to this fact a modified negative feedback is created in which the regulation of major and minor ranges is not uniform. For the all laboratorial parameters exists five zones: optimum (1), admissible (2a., 2b), dangerous (3a., 3b), inactivity (4a., 4b) and inviability (5a., 5b). As a conclusion, the present medical science reserves the word perinormal for naming biophysical, biochemical and physiological responses in a wide range that warn us referring to the existence of mainly quantitative or reversible qualitative changes and the possibility of irreversibly pathological qualitative alterations. The role of the biophysics consists of the study of the vital processes which take place in the living organisms, their correlations in the discovery of the causal relationships betOuren the phenomena, establishing the underlying connections and the quality differences of the processes which take place in the living organism.
Inter-Rater Reliability of ST-Segment Measurement at a University Hospital in Argentina
Authors:   Department of Medicine, Hospital de Clínicas “José de San Martín”, Buenos Aires, Argentina, Martín Santarelli Ignacio , Costa Diego , Swieszkowski Sandra , Perez de La Hoz Ricardo
Published: May 2022

The accurate determination of the electrocardiographic ST-segment elevation in a patient with clinical suspicion of acute coronary syndrome is essential for treatment with urgent myocardial reperfusion. The aim of this study was to determine the inter-rater reliability of ischemic and non-ischemic ST-segment elevation measurement among physicians with different specialties and experience. We performed an observational, cross-sectional study, with a comparative correlation and paired sampling. 56 physicians from a university hospital in Buenos Aires city were included: Cardiologists from the Coronary Care Unit (CCU) and Cardiology Division, Internal Medicine physicians from the hospitalization, ambulatory care and Emergency divisions, and third- and fourth-year Internal Medicine residents. Each participant analyzed 6 electrocardiograms and was asked to determine the magnitude of the ST-segment elevation at the J-point, and the corresponding diagnosis. The inter-rater coefficient was lower than 0.2, and the global kappa coefficient was 0.06 (p < 0.001). The global correct interpretations were: inferior wall myocardial infarction (MI): 89.3%; anterior wall MI: 51.8%; lateral wall MI: 75%; left bundle branch block: 91.1%; left ventricle hypertrophy: 44.6%; acute pericarditis: 25%. We believe that the low correlation was probably due to the difficulty in determining the J-point. These findings could suggest the need to strengthen the electrocardiographic concepts of ischemia, and the differentiation between ischemic and non-ischemic ST-segment elevations.
Frequency and Risk Factors Association of Fall Among the Idiopathic Parkinson’s Patients in Jashore, Bangladesh
Authors: Kumar Acherjya Goutam , Ali Mohammad , Kamal Mostofa , Chakkraborty Rajashish , Shahadat Md Anwar , Srinivashan AV
Published: May 2022

Parkinson’s disease is the second most common neuro degenerative disease worldwide. Fall is common scenario in our day to day clinical practice among the older people but it is more common among the Parkinson’s people. The study was conducted to assess the frequency of fall and to ascertain the risk association among the idiopathic Parkinson’s patients. This observational study was conducted from July to December, 2018 in the district of Jashore, Bangladesh. Both the male and female clinically diagnosed as idiopathic Parkinson’s disease without taking antiparkinsonian medication were recruited in the study. Those having Parkinson’s disease due to stroke or secondary causes, orthostatic hypotension, taking anti parkinsonian drugs and the drugs may mimicking Parkinson’s disease were excluded from the study. A total 111 patients were analyzed of which 69.4% (N=77) male and 30.6% (N=34) female with the mean age of our participants was 66±10 years. The event of fall among the idiopathic Parkinson’s patients was 36.9% in the last one year where single, two and three or more episodes of fall were 20.7%, 3.6% and 12.6% respectively. No significant difference observed between faller and non-fallers among different demographic characteristics including age (p: 0.091) sex (p: 0.058) educational level (p: 0.235), occupational status (p: 0.220) and residency (p: 0.547). Experience of fall found more in high BMI (p: 0.037), hypertensive (p: 0.018), diabetic (p: 0.009) and in patients receiving multiple medications (p: 0.011). But duration of Parkinsonism (p: 0.835) does not increase fall. Based on this study, we have found that there is high frequency of fall among the idiopathic Parkinson’s patients. So, earlier identification and potential strategies to remove the risk factors may prevent falls and falls related events, thus finally reducing the morbidity and mortality in the Parkinson’s patients.
Oropharyngeal Dysphagia with Aspiration as a Provoking Factor for COPD Exacerbation
Authors:   Faculty of Medicine, University of Jordan, Amman, Jordan, Sameh Darwich Noor , Chowdhry Pracha Shamsuddin , Ann Miller Natalie
Published: May 2022

The most common provoking factors for chronic Obstructive Pulmonary Disease (COPD) exacerbation include viral and bacterial tracheobronchitis, pneumonia, and exposure to environmental irritants and air pollution. In many patients with COPD exacerbation, the underlying cause cannot be identified. In general, patients with COPD exacerbation get admitted to the hospital and treated with antibiotics, glucocorticoids and inhaled bronchodilators. Oropharyngeal dysphagia is an under-recognized provoking factor for COPD exacerbation. Patients with advanced COPD often have impaired coordination of respiration and deglutition which can lead to aspiration of liquids, food particles, and saliva into the airways. Aspiration events can lead to exacerbation of symptoms and cause further decline in lung function. We described a 69-year-old male with a history of COPD who presented with progressive dyspnea, productive cough and hypoxia which required intubation and mechanical ventilation. The patient underwent a bronchoscopy for airway inspection which showed pieces of meat in the right main bronchus which were removed. Reportedly, the patient was having difficulty swallowing solid food prior to admission to the hospital.
Overexpression of the ubiquitin-editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system
Authors:   Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy, Bertolotto Antonio ,   Neurobiology Unit, Neurology – CReSM (Regional Referring Center of Multiple Sclerosis), San Luigi Gonzaga University Hospital, Orbassano, Italy., Magliozzi Roberta , Bertolo Jessica , Bono Gabriele , Bonaldo Brigitta , Martire Serena , Montarolo Francesca , Perga Simona
Published: May 2022

Multiple Sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) in which inflammation plays a key pathological role. Recent evidences showed that systemic inflammation induces increasing cell infiltration within meninges and perivascular spaces in the brain parenchyma, triggering resident microglial and astrocytic activation. The anti-inflammatory enzyme A20, also named TNF associated protein 3 (TNFAIP3), is considered a central gatekeeper in inflammation and peripheral immune system regulation through the inhibition of NF-kB. The TNFAIP3 locus is genetically associated to MS and its transcripts is downregulated in blood cells in treatment-naïve MS patients. Recently, several evidences in mouse models have led to hypothesize a function of A20 also in the CNS. Thus, here we aimed to unveil a possible contribution of A20 to the CNS human MS pathology. By immunohistochemistry/immunofluorescence and biomolecular techniques on post-mortem brain tissue blocks obtained from control cases (CC) and progressive MS cases, we demonstrated that A20 is present in CC brain tissues in both white matter (WM) regions, mainly in few parenchymal astrocytes, and in grey matter (GM) areas, in some neuronal populations. Conversely, in MS brain tissues, we observed increased expression of A20 by perivascular infiltrating macrophages, resident-activated astrocytes, and microglia in all the active and chronic active WM lesions. A20 was highly expressed also in the majority of active cortical lesions compared to the neighboring areas of normal-appearing grey matter (NAGM) and control GM, par-ticularly by activated astrocytes. We demonstrated increased A20 expression in the active MS plaques, particularly in macrophages and resident astrocytes, suggesting a key role of this molecule in chronic inflammation.