bluuebunny/crossref_metadata_2025 huggingface dataset:
Probiotics suppress nonalcoholic steatohepatitis and carcinogenesis progression in hepatocyte-specific PTEN knockout mice
Authors: Arai Naoshi , Miura Kouichi , Aizawa Kenichi , Sekiya Mariko , Nagayama Manabu , Sakamoto Hirotsugu , Maeda Hiroshi , Morimoto Naoki , Iwamoto Sadahiko , Yamamoto Hironori
Published: September 2022

Nonalcoholic fatty liver disease (NAFLD), a hepatic characteristic of metabolic syndrome, received significant attention in clinical settings. The multiple-hit theory is one of the proposed mechanisms of NAFLD, and gut dysbiosis is considered a hit. Thus, controlling gut microbiota is a potential target in the management of NAFLD, and probiotics can be used as a treatment agent for NAFLD. The current study aimed to investigate the efficacy of probiotics against nonalcoholic steatohepatitis in a hepatocyte-specific PTEN knockout mouse model that mimics the characteristics of human NAFLD. Probiotics were administered to male knockout mice for 8 or 40 weeks. Next, we assessed hepatic inflammation, fibrosis, carcinogenesis, and oxidative stress. Probiotics were found to reduce serum transaminase levels, NAFLD activity score, and the gene expression of pro-inflammatory cytokines. In addition, they decreased liver fibrosis grade, which was examined via Sirius red staining, gene expression of fibrotic markers, and hydroxyproline. Furthermore, probiotics suppressed the number of liver tumors, particular in HCC. Probiotics reduced oxidative stresses, including glutathione levels, and anti-oxidative stress marker, which may be an underlying mechanism for their beneficial effects. In conclusion, probiotics treatment had beneficial effects against NAFLD and carcinogenesis in hepatocyte-specific PTEN knockout mice.
Application of machine learning in predicting oil rate decline for Bakken shale oil wells
Authors: Bhattacharyya Subhrajyoti , Vyas Aditya
Published: September 2022

Commercial reservoir simulators are required to solve discretized mass-balance equations. When the reservoir becomes heterogeneous and complex, more grid blocks can be used, which requires detailed and accurate reservoir information, for e.g. porosity, permeability, and other parameters that are not always available in the field. Predicting the EUR (Estimated Ultimate Recovery) and rate decline for a single well can therefore take hours or days, making them computationally expensive and time-consuming. In contrast, decline curve models are a simpler and speedier option because they only require a few variables in the equation that can be easily gathered from the wells' current data. The well data for this study was gathered from the Montana Board of Oil and Gas Conservation's publicly accessible databases. The SEDM (Stretched Exponential Decline Model) decline curve equation variables specifically designed for unconventional reservoirs variables were correlated to the predictor parameters in a random oil field well data set. The study examined the relative influences of several well parameters. The study's novelty comes from developing an innovative machine learning (ML) (random forest (RF)) based model for fast rate-decline and EUR prediction in Bakken Shale oil wells. The successful application of this study relies highly on the availability of good quality and quantity of the dataset.
Dual attention network for unsupervised medical image registration based on VoxelMorph
Authors: Li Yong-xin , Tang Hui , Wang Wei , Zhang Xiu-feng , Qu Hang
Published: September 2022

An accurate medical image registration is crucial in a variety of neuroscience and clinical studies. In this paper, we proposed a new unsupervised learning network, DAVoxelMorph to improve the accuracy of 3D deformable medical image registration. Based on the VoxelMorph model, our network presented two modifications, one is adding a dual attention architecture, specifically, we model semantic correlation on spatial and coordinate dimensions respectively, and the location attention module selectively aggregates the features of each location by weighting the features of all locations. The coordinate attention module further puts the location information into the channel attention. The other is introducing the bending penalty as regularization in the loss function to penalize the bending in the deformation field. Experimental results show that DAVoxelMorph achieved better registration performance including average Dice scores (0.714) and percentage of locations with non-positive Jacobian (0.345) compare with VoxelMorph (0.703, 0.355), CycleMorph (0.705, 0.133), ANTs SyN (0.707, 0.137) and NiftyReg (0.694, 0.549). Our model increases both model sensitivity and registration accuracy.
Utilization and compliance with iron supplementation and predictors among pregnant women in Southeast Ethiopia
Authors: Beressa Girma , Lencha Bikila , Bosha Tafese , Egata Gudina
Published: September 2022

Anemia is predicted to affect 38% (32 million) of pregnant women worldwide. However, evidence for utilization and compliance with iron supplementation and predictors during pregnancy in low-income countries, including Ethiopia, is sparse and inconclusive. Therefore, we aimed to assess utilization and compliance with iron supplementation and predictors among pregnant women in Robe Town, Southeast Ethiopia. A community-based cross-sectional study was employed among randomly selected 445 pregnant women attending antenatal care at health facilities from May to July 2015. A systematic random sampling was used to select respondents. Data were collected using a pre-tested, interviewer-administered, structured questionnaire. Bivariable and multivariable logistic regression analyses were conducted to identify predictors of compliance with iron supplementation. An odds ratio, along with a 95% confidence interval (CI), was used to estimate the strength of the association. In this study, 54% [95% CI (49.4, 58.4%)], 45.2% [95% CI (40.9, 49.4%)], 4.3% [95% CI (2.5, 6.3%)], and 2.2% [95% CI (1.1, 3.6%)] of women received iron supplements during their first, second, third, and fourth antenatal care visits, respectively. The level of compliance with iron supplementation was 92.4% [95% CI (89.9, 94.6%)]. Having a formal education (AOR = 4.45, 95% CI 1.41, 13.99), being in the high wealth quintile (AOR = 0.18, 95% CI 0.05, 0.68), medium wealth quintile [(AOR = 0.33, 95% CI (0.11, 0.98)], receiving iron supplements for free (AOR = 3.77, 95% CI 1.33, 10.69), not experiencing discomfort related to iron supplements intake (AOR = 2.94, 95% CI 1.17, 7.39), having comprehensive knowledge about anemia (AOR = 2.62, 95% CI 1.02, 6.70), being knowledgeable about iron supplements (AOR = 3.30, 95% CI 1.12, 9.76), having information about importance of iron supplementation during pregnancy (AOR = 2.86; 95% CI 1.04, 7.87), and ever being visited by urban health extension workers (AOR = 0.31; 95% CI 0.12, 0.83) was significantly associated with compliance with iron supplementation during pregnancy. The utilization of iron supplementation during pregnancy was low, with relatively high compliance with the supplements. Thus, comprehensive nutrition education and free provision of iron supplementation are crucial tools to increase utilization and compliance with iron supplementation during pregnancy. Further research with a strong study design using golden standard methods is warranted.
Spatial distribution and interactions between mosquitoes (Diptera: Culicidae) and climatic factors in the Amazon, with emphasis on the tribe Mansoniini
Authors: de Mello Cecilia Ferreira , Figueiró Ronaldo , Roque Rosemary Aparecida , Maia Daniele Aguiar , da Costa Ferreira Vânia , Guimarães Anthony Érico , Alencar Jeronimo
Published: September 2022

This work aimed to evaluate the spatial distribution of mosquitoes in different seasonal periods and the interaction between climatic factors and the abundance of mosquitoes, especially those belonging to the tribe Mansoniini in the area surrounding the Amazon hydroelectric production region (Jirau-HP) of Rondônia state, Brazil. Mosquito specimens were collected in May, July, October, and December 2018, and April, July, September, and November 2019, over periods of three alternating days during the hours of 6:00 p.m. to 8:00 p.m. Mosquito sampling was performed using automatic CDC and Shannon light traps. Canonical correspondence analysis (CCA), combined with Monte Carlo permutations, was used to evaluate the correlation between climatic variables and species distribution. In addition, non-metric multidimensional scaling (NMDS) was used to verify the similarity among the sampled communities from the different collections. After analyzing the total mosquito fauna at all sampling points, 46,564 specimens were identified, with Mansonia dyari showing the highest relative abundance in 2018 (35.9%). In contrast, Mansonia titillans had the highest relative abundance in 2019 (25.34%), followed by Mansonia iguassuensis (24.26%). The CCA showed that maximum temperature significantly influenced the distribution of mosquito populations in the study area (p = 0.0406). The NMDS showed that sampling carried out in the rainy and dry seasons formed two distinct groups. There was a significant correlation between species richness and cumulative precipitation 15 days before the sampling period (R2 = 58.39%; p = 0.0272). Thus, both temperature and precipitation affected mosquito population dynamics. The effect of rainfall on mosquito communities may be due to variations in habitat availability for immature forms.
Flap structure within receptor binding domain of SARS-CoV-2 spike periodically obstructs hACE2 Binding subdomain bearing similarities to HIV-1 protease flap
Authors: Peters Michael H.
Published: September 2022

The SARS-CoV-2 prefusion spike protein is characterized by a high degree of flexibility and temporal transformations associated with its multifunctional behavior. In this study, we have examined the dynamics of the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein in detail. Its primary, binding subdomain with human Angiotensin Covering Enzyme II includes a highly conspicuous flap or loop that is part of a beta hairpin loop structural motif. Dynamic details of the RBD obtained through RMSF and Order Parameter calculations are consistent with structural details including the stability of “glue” points or dominant interaction energy residues of the RBD in the Up and Down states with its neighboring N-terminal domain (NTD) protomer. The RBD flap in the Up state protomer periodically obstructs the binding site on an approximate 70 ns time interval and is reminiscent of an HIV-1 protease polypeptide flap that opens and closes to modulate that enzymes activity. No claim is made here regarding the possible modulating role of the flap; however, the flap may be a potential site for therapeutic targeting aimed at keeping it in the closed state, as previously demonstrated in the inhibition of the HIV-1 protease polypeptide. The RBD primary binding subdomain is further shown to have not only similar dynamics but, also, an approximate 30% sequence similarity to the HIV-1 protease polypeptide.
Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics
Authors: Hargrove Tatiana Y. , Lamb David C. , Smith Jarrod A. , Wawrzak Zdzislaw , Kelly Steven L. , Lepesheva Galina I.
Published: September 2022

The molecular evolution of cytochromes P450 and associated redox-driven oxidative catalysis remains a mystery in biology. It is widely believed that sterol 14α-demethylase (CYP51), an essential enzyme of sterol biosynthesis, is the ancestor of the whole P450 superfamily given its conservation across species in different biological kingdoms. Herein we have utilized X-ray crystallography, molecular dynamics simulations, phylogenetics and electron transfer measurements to interrogate the nature of P450-redox partner binding using the naturally occurring fusion protein, CYP51-ferredoxin found in the sterol-producing bacterium Methylococcus capsulatus. Our data advocates that the electron transfer mechanics in the M. capsulatus CYP51-ferredoxin fusion protein involves an ensemble of ferredoxin molecules in various orientations and the interactions are transient. Close proximity of ferredoxin, however, is required to complete the substrate-induced large-scale structural switch in the P450 domain that enables proton-coupled electron transfer and subsequent oxygen scission and catalysis. These results have fundamental implications regarding the early evolution of electron transfer proteins and for the redox reactions in the early steps of sterol biosynthesis. They also shed new light on redox protein mechanics and the subsequent diversification of the P450 electron transfer machinery in nature.
Flexible ultrasound transceiver array for non-invasive surface-conformable imaging enabled by geometric phase correction
Authors: Elloian Jeffrey , Jadwiszczak Jakub , Arslan Volkan , Sherman Jeffrey D. , Kessler David O. , Shepard Kenneth L.
Published: September 2022

Ultrasound imaging provides the means for non-invasive real-time diagnostics of the internal structure of soft tissue in living organisms. However, the majority of commercially available ultrasonic transducers have rigid interfaces which cannot conform to highly-curved surfaces. These geometric limitations can introduce a signal-quenching air gap for certain topographies, rendering accurate imaging difficult or impractical. Here, we demonstrate a 256-element flexible two-dimensional (2D) ultrasound piezoelectric transducer array with geometric phase correction. We show surface-conformable real-time B-mode imaging, down to an extreme radius of curvature of 1.5 cm, while maintaining desirable performance metrics such as high signal-to-noise ratio (SNR) and minimal elemental cross-talk at all stages of bending. We benchmark the array capabilities by resolving reflectors buried at known locations in a medical-grade tissue phantom, and demonstrate how phase correction can improve image reconstruction on curved surfaces. With the current array design, we achieve an axial resolution of ≈ 2 mm at clinically-relevant depths in tissue, while operating the array at 1.4 MHz with a bandwidth of ≈ 41%. We use our prototype to image the surface of the human humerus at different positions along the arm, demonstrating proof-of-concept applicability for real-time diagnostics using phase-corrected flexible ultrasound probes.
Predicting fertility from sperm motility landscapes
Authors: Fernández-López Pol , Garriga Joan , Casas Isabel , Yeste Marc , Bartumeus Frederic
Published: September 2022

Understanding the organisational principles of sperm motility has both evolutionary and applied impact. The emergence of computer aided systems in this field came with the promise of automated quantification and classification, potentially improving our understanding of the determinants of reproductive success. Yet, nowadays the relationship between sperm variability and fertility remains unclear. Here, we characterize pig sperm motility using t-SNE, an embedding method adequate to study behavioural variability. T-SNE reveals a hierarchical organization of sperm motility across ejaculates and individuals, enabling accurate fertility predictions by means of Bayesian logistic regression. Our results show that sperm motility features, like high-speed and straight-lined motion, correlate positively with fertility and are more relevant than other sources of variability. We propose the combined use of embedding methods with Bayesian inference frameworks in order to achieve a better understanding of the relationship between fertility and sperm motility in animals, including humans.
Label-free fibre optic Raman spectroscopy with bounded simplex-structured matrix factorization for the serial study of serum in amyotrophic lateral sclerosis
Authors: Alix James J. P. , Verber Nick S. , Schooling Chlöe N. , Kadirkamanathan Visakan , Turner Martin R. , Malaspina Andrea , Day John C. C. , Shaw Pamela J.
Published: September 2022

We demonstrate the use of a fibre optic fluid cell to undertake spontaneous Raman spectroscopy. Advanced advanced matrix factorisation is then applied to identify key spectral patterns with potential improvements to clinical trial design.
Correction: UPLC-MS/MS determination and pharmacokinetic study of 26-OH-panaxadiol in rat plasma
Authors: Lin Meiyu , Gao Hongmei , Liu Jinping , Han Liu , Zhang Qinghe , Li Pingya
Published: September 2022

Correction for ‘UPLC-MS/MS determination and pharmacokinetic study of 26-OH-panaxadiol in rat plasma’ by Meiyu Lin et al., Anal. Methods, 2013, 5, 6656–6662, https://doi.org/10.1039/C3AY41320A.
In situ excitation of BODIPY fluorophores by 89Zr-generated Cerenkov luminescence
Authors: Gristwood Katie , Luli Saimir , Rankin Kenneth S. , Knight James C.
Published: September 2022

Secondary Cerenkov-induced fluorescence imaging (SCIFI) is an emerging optical imaging modality that affords high signal-to-noise images. This report examines the utility of BODIPY fluorophores in SCIFI applications using 89Zr-generated Cerenkov luminescence.
Crystalline phosphino(silyl)carbenes that readily form transition metal complexes
Authors: Löwe Pawel , Dielmann Fabian
Published: September 2022

We describe the synthesis of phosphino(silyl)carbenes bearing N-heterocyclic imine groups and show that these isolable, crystalline carbenes readily form stable copper(i) and gold(i) complexes.
Movable triple points and Dirac points in centrosymmetric AB2 (A = Cr, Mo; B = Si, Ge) compounds
Authors: Zhang Yu , Dai Xuefang , He Tingli , Liu Wei , Wang Lirong , Yu Weiwang , Xu Long , Liu Ying , Zhang Xiaoming , Liu Guodong
Published: September 2022

Centrosymmetric AB2 (A = Cr, Mo; B = Si, Ge) compounds host movable triple degenerate points without SOC and Dirac points with SOC.
Buoyancy and Brownian motion of plastics in aqueous media: predictions and implications for density separation and aerosol internal mixing state
Authors: Bain Alison
Published: September 2022

Nano- and microplastics exist in the environment and atmosphere in mixed-phase aqueous systems. The density and size of plastics as well as the density of the liquid phase determines if these plastics will float or diffuse through the liquid.
Transformation of zinc oxide nanoparticles in freshwater sediments under oxic and anoxic conditions
Authors: Stetten Lucie , Hofmann Thilo , Proux Olivier , Landrot Gautier , Kaegi Ralf , von der Kammer Frank
Published: September 2022

This study improves the understanding of ZnO NP transformation and Zn behavior in redox-dynamic slightly alkaline freshwater sediments.
Base-selective access to highly functionalized heterocycles from multicomponent Ugi adducts
Authors: González-Saiz Beatriz , Pertejo Pablo , Peña-Calleja Pablo , Mielczarek Marcin , Hermosilla Tomás , Carreira-Barral Israel , de Miguel Olivia , Rodríguez-Vidal Francisco , Quesada Roberto , García-Valverde María
Published: September 2022

Selection of the appropriate base in Ugi/post-condensation sequences allows the selective syntheses of different ring-size functionalized lactams.
Synthesis of dihydroindazolo[2,3-f]phenanthridin-5(6H)-onesviaRh(iii)-catalyzed C–H activation of 2-aryl indazoles and annulation with iodonium ylides
Authors: Liang Jiazhi , Huang Jian , Yang Qin , Fu Yang , Ding Qiuping , Peng Yiyuan
Published: September 2022

The Rh(iii)-catalyzed annulation of 3-arylindazoles with iodonium ylides gave indazole fused dihydrophenanthridinones in excellent yields under mild conditions. The reaction only requires simple work-up procedures, and the catalyst can be recycled.
Manganese-catalysed dehydrogenative oxidation of glycerol to lactic acid
Authors: Deng Chen-Qiang , Deng Jin , Fu Yao
Published: September 2022

An efficient and robust pincer manganese complex for the dehydrogenative oxidation of glycerol to lactic acid with dihydrogen liberation is presented.
Applications of novel composite UiO-66-NH2/Melamine with phosphorous acid tags as a porous and efficient catalyst for the preparation of novel spiro-oxindoles
Authors: Tavakoli Elham , Sepehrmansourie Hassan , Zarei Mahmoud , Zolfigol Mohammad Ali , Khazaei Ardeshir , Hosseinifard Mojtaba
Published: September 2022

A new approach for the incorporation of phosphorous acid tags into a metal organic framework based on UiO-66-NH2/Melamine was introduced. This new catalyst was applied to the preparation of novel spiro-oxindoles under mild and green conditions.
Synthesis of alpha-pyrones and chromen-2-ones by transition-metal catalyzed annulations of sulfoxonium and iodonium ylides withcis-stilbene acids
Authors: John Stephy Elza , Bora Darshana , Dastari Sowmya , Valapil Durgesh Gurukkala , Shankaraiah Nagula
Published: September 2022

The protocol represents the efficiency of a C–H activation strategy in the construction of pharmacophoric and chromophoric structures employingcis-stilbene acids as directing groups.
Organic composite photocatalysts from g-C3N4 and a soluble dibenzothiophene-S,S′-dioxide-containing polymer for hydrogen evolution
Authors: Mao Na , Jiang Jia-Xing
Published: September 2022

The inbuilt electric field of PHJ is advantageous for enhancing the photocatalytic activity of g-C3N4/PFSO composites.
Visible light-driven copper(ii) catalyzed aerobic oxidative cleavage of carbon–carbon bonds: a combined experimental and theoretical study
Authors: Li Sanliang , Tian Dong , Zhao Xiaowei , Yin Yanli , Lee Richmond , Jiang Zhiyong
Published: September 2022

By switching on visible blue light, aerobic oxidation of various substrates, such as α-substituted, β-substituted and α-halo styrenes, was first realized with a copper(ii) catalyst.
Facile fabrication of composite cellulose fibrous materials for efficient and consecutive dyeing wastewater treatment
Authors: Xie Dandan , Fu Qiuxia , Wang Yue , Ge Jianlong , Wang Hailou , Zhang Yu , Zhang Wei , Shan Haoru
Published: September 2022

Composite materials of polydopamine decorated cellulose fibrous nonwovens were fabricated for efficient and consecutive dyeing wastewater treatment.
Electrophoretic deposition of hydroxyapatite/chitosan nanocomposites: the effect of dispersing agents on the coating properties
Authors: Gaafar M. S. , Yakout S. M. , Barakat Y. F. , Sharmoukh W.
Published: September 2022

Electrophoretic deposition was used for coating of titanium substrate with a composite of hydroxyapatite (HA)-chitosan (CS) in the presence of polyvinyl butyral (PVB), polyethylene glycol (PEG), and triethanolamine (TEA).
Understanding chemistry: from “heuristic (soft) explanations and reasoning by analogy” to “quantum chemistry”
Authors: Seeman Jeffrey I. , Tantillo Dean J.
Published: September 2022

“Soft theories” largely drove chemical understanding for 150 years or more. In the past 50 years, quantum chemistry has provided (a) the underlying “hard evidence” for many soft theories and (b) the explanations for chemical phenomena that are unavailable by soft theories.
Design of densified nickel-rich layered composite cathode via the dry-film process for sulfide-based solid-state batteries
Authors: Shin DongJin , Nam Jae Seok , Linh Nguyen Chi Thi , Jo Younghoon , Lee Kyusik , Hwang Soo Min , Kim Young-Jun
Published: September 2022

Densified composite cathodes through dry-film process comprising different content of LiNi0.8Co0.15Al0.05O2 and Li6PS5Cl particles and their charge transport kinetics in solid-state batteries are studied by AC impedance and DC polarization analyses.
Defect engineering of Ni3S2 nanosheets with highly active (110) facets toward efficient electrochemical biomass valorization
Authors: Zheng Lingxia , Lv Zhuoqing , Xu Penghui , Xu Hanshuai , Zhu Mengkai , Zhao Yujuan , Shi Xiaowei , Wang Hong-En , Zheng Huajun
Published: September 2022

Creating S vacancies in Ni3S2 can effectively modulate the electronic structure and surface properties, which adjusts the adsorption behaviors during benzyl alcohol electro-oxidation thereby dramatically boost the catalytic activity.
Inhibiting the decomposition of methylammonium using cations with low deprotonation energy
Authors: Zhou Tingwei , Chen Jiangzhao , Kuang Anlong
Published: September 2022

CH3NH2 can be converted into the MA+ ion using cations with low deprotonation energy, suggesting that the decomposition of MA+ can be inhibited. Moreover, the MAPbI3 perovskites with H5O2 show excellent electronic structures and high efficiency.
Molecular insights into capacitive deionization mechanisms inside hydrophobic and hydrophilic carbon nanotube channel electrodes
Authors: Saffarimiandoab Farzin , Sabetvand Roozbeh , Zhang Xihui
Published: September 2022

Constant-potential molecular dynamics simulations were performed to evaluate the influence of wettability and pore diameter of carbon-nanotube electrodes on deionization mechanisms.
Construction of symbiotic one-dimensional ionic channels in a cobalt-based covalent organic framework for high-performance oxygen reduction electrocatalysis
Authors: Ren Rong , Yang Liting , Lin Zhang , Li Xiaoyu , Zhang Shuomeng , Zheng Tianlong , Wu Duojie , Wang Jian , Wei Zidong , Ding Wei , Huang Ning , Gu Meng , He Qinggang
Published: September 2022

Symbiotic ion channels were constructed in covalent framework catalysts to improve ionic mass transfer in the AEMFC cathodic catalyst layer.
Versatile Fe2GeS4 for Li/Na–Fe2GeS4 battery cathodes and Li/Na-ion battery anodes
Authors: Ganesan Vinoth , Nam Ki-Hun , Kim Jae-Hun , Park Cheol-Min
Published: September 2022

A ternary Fe2GeS4 compound was synthesized using a simple solid-state method and applied as versatile electrodes for rechargeable Li/Na–Fe2GeS4 battery cathodes and Li/Na-ion battery anodes.
Fast charge transfer between iodide ions and a delocalized electron system on the graphite surface for boosting hydrogen production
Authors: Peng Shih-Mao , Patil Shivaraj B. , Chang Chun-Chih , Chang Shu-Ting , Chen Yi-Chia , Wu Kuan-Chang , Su Wei-Nien , Hwang Bing Joe , Wang Di-Yan
Published: September 2022

The graphite-based materials with a delocalized π electron system exhibited fast charge transfer with physically adsorbed iodide ions, thus revealing desirable IOR catalytic activity.
Advances in applications of piezoelectronic electrons in cell regulation and tissue regeneration
Authors: Zhou Lijun , Yuan Tao , Jin Fei , Li Tong , Qian Lili , Wei Zhidong , Zheng Weiying , Ma Xiying , Wang Fuyi , Feng Zhang-Qi
Published: September 2022

We summarized the mechanisms of cellular response to piezoelectronic electrons and the applications of piezoelectronic electrons in cell regulation and tissue regeneration according to the types of cells and tissues.
An all-inorganic Li-doped Cs3Cu2I5 single crystal for dual gamma ray and neutron detection applications
Authors: Xiang Peng , Wei Qinhua , Wang Chenger , Cai Peiqing , Tong Yufeng , Tang Gao , Sun Xilei , Yang Fan , Shi Hongsheng , Liu Zugang , Qin Laishun
Published: September 2022

Study on the growth and scintillation mechanism of Li+-doped Cs3Cu2I5 crystal with an excellent FOM value for dual gamma-ray and neutron detection applications.
A hydrogel electrolyte based on the inhibitory activity of water forin situsupercapacitors
Authors: Zhang Rongda , Chen Zhimin , Gao Guanghui
Published: September 2022

Herein, a hydrogel supercapacitor with high structural stability was prepared byin situpolymerization. Meanwhile, inhibitory activity of water in the hydrogel was successfully achieved by introducing quaternary ammonium groups on the main chain.
Half-metallic double perovskite oxides: recent developments and future perspectives
Authors: Tang Qingkai , Zhu Xinhua
Published: September 2022

This review summarizes the recent progress of half-metallic double perovskite oxides from theoretical and experimental aspects as well as their versatile applications.
Copper-based metal oxides for chemiresistive gas sensors
Authors: Ding Yanqiao , Guo Xuezheng , Zhou Yong , He Yong , Zang Zhigang
Published: September 2022

This review provides a comprehensive summary of the current progress in copper-based metal oxide chemiresistive gas sensors from the aspects of synthesis strategies, morphological influence, functional strategies, and excitation strategies.
A fast layered path planning algorithm for job shop scheduling problem
Authors: Huang Lin , Zhao Shikui , Han Qing
Published: September 2022

Job shop scheduling problem (JSP) is a classical system resource optimisation problem and also an NP hard problem. The search algorithm based on Akers obstacle graph model is an effective algorithm to solve JSP, which first removes part of jobs from the original schedule, then constructs obstacle graph and finds the shortest path from the graph, and finally reinserts the jobs according to the shortest path decoding method to get the new schedule. Although the new scheduling can achieve good results, it is time‐consuming to find the shortest path. Therefore, it is necessary to further study how to quickly plan the shortest path. This study presents a fast layered path search algorithm for solving the obstacle graph of job shop scheduling. The algorithm designs a node expansion method and a delay distance formula. The obstacles generated by different machines in the obstacle graph are layered. When the nodes expand, the extended nodes are compared with the parent layer nodes to quickly avoid closely arranged obstacles, and multiple child nodes are generated at one time through node expansion to improve the node expansion ability. At the same time, node expansion method and delay distance formula can be well integrated with A* algorithm. Finally, the test verifies that the algorithm can spend less time to find the shortest path.
Thermal ageing of soft and hard epoxy resins
Authors: Ohki Yoshimichi , Hirai Naoshi
Published: September 2022

Two kinds of epoxy resin, a soft one with rubber‐based additives and an ordinary hard one, are used as electrical insulators and airtight sealants in electrical penetrations in nuclear power plants (NPPs). Knowing how they behave under adverse environments is important for the safe operation of NPPs. In this regard, we gave artificial thermal ageing treatment to the two resins by heating them in air at various temperatures. The resins were then subjected to mechanical, thermal, and dielectric tests. As a result, it has become clear that the soft epoxy resin becomes hard, while its permittivity and loss factor decrease as the heating becomes longer. The glass transition tends to occur at a high temperature in the soft epoxy resin when it was heated. With these changes, the soft resin tends to exhibit similar behaviour in various properties to that of the unaged hard one. On the other hand, the hard one is hardly affected by the simulated thermal ageing. Therefore, both resins can be useable in NPPs.
The method of intelligent wireless sensor to improve the water permeability of permeable asphalt concrete pavement
Authors: Zhang Xingmei , Xu Cong , Lei Qi
Published: September 2022

This research aims to study the intelligent wireless sensor to improve the water permeability of permeable asphalt concrete pavement. The water permeability of pavement is extremely important for the traffic environment. This study first briefly introduces the background and significance analysis, and then exemplifies the deployment algorithm and model of wireless sensors on asphalt pavement. For example, the wireless sensor deployment strategy along the asphalt pavement based on linear dual sink nodes can be divided into linear wireless sensor node deployment, wireless sensor energy consumption model, and wireless sensor zone coverage principle. Another example is the wireless sensor network (WSN) deployment model along the asphalt road and the wireless sensor structure model, which are divided into WSN structure, sensor node structure, gateway interconnection of WSNs and other types of networks. Then this study conducts experiments and results analysis based on wireless sensors for improving the permeability of asphalt pavement and asphalt content. In this study, the factors affecting the water permeability of asphalt pavement are tested, and the application of sensors in testing its performance, and the optimal asphalt ratio is selected in the experiment to make its water permeability better. Finally, the study discusses and summarises the experiments, and it is concluded that the optimum asphalt content in the mixture is 5.48%–6.22%. Influencing factors include temperature and humidity, void ratio, cross slope gradient and so on. This experiment has a good reference prospect.
Second quantised information distance
Authors: Dai Songsong
Published: September 2022

The Kolmogorov complexity of a string is the minimum length of a programme that can produce that string. Information distance between two strings based on Kolmogorov complexity is defined as the minimum length of a programme that can transform either string into the other one, both ways. The second quantised Kolmogorov complexity of a quantum state is the minimum average length of a quantum programme that can reproduce that state. In this paper, a second quantised information distance is defined based on the second quantised Kolmogorov complexity. It is described as the minimum average length of a transformation quantum programme between two quantum states. This distance's basic properties are discussed. A practical analogue of quantum information distance is also developed based on quantum data compression.
Galaxy–galaxy lensing in the VOICE deep survey
Authors: Luo Ruibiao , Fu Liping , Luo Wentao , Napolitano Nicola R. , Xie Linghua , Radovich Mario , Liu Jing , Li Rui , Amaro Valeria , Chen Zhu , Liu Dezi , Fan Zuhui , Covone Giovanni , Vaccari Mattia
Published: September 2022

The multi-band photometry of the VOICE imaging data, overlapping with 4.9 deg2of theChandraDeep Field South (CDFS) area, enables both shape measurement and photometric redshift estimation to be the two essential quantities for weak lensing analysis. The depth of magABis up to 26.1 (5σlimiting) inr-band. We estimate the excess surface density (ESD; ΔΣ) based on galaxy–galaxy measurements around galaxies at lower redshift (0.10 < zl < 0.35) while we select the background sources as those at higher redshift ranging from 0.3 to 1.5. The foreground galaxies are divided into two major categories according to their colour (blue and red), each of which has been further divided into high- and low-stellar-mass bins. The halo masses of the samples are then estimated by modelling the signals, and the posterior of the parameters are sampled using a Monte Carlo Markov chain process. We compare our results with the existing stellar-to-halo mass relation (SHMR) and find that the blue low-stellar-mass bin (medianM* = 108.31 M⊙) deviates from the SHMR relation whereas the other three samples agree well with empirical curves. We interpret this discrepancy as the effect of the low star-formation efficiency of the low-mass blue dwarf galaxy population dominated in the VOICE-CDFS area.
The KOBE experiment: K-dwarfs Orbited By habitable Exoplanets
Authors: Lillo-Box J. , Santos N. C. , Santerne A. , Silva A. M. , Barrado D. , Faria J. , Castro-González A. , Balsalobre-Ruza O. , Morales-Calderón M. , Saavedra A. , Marfil E. , Sousa S. G. , Adibekyan V. , Berihuete A. , Barros S. C. C. , Delgado-Mena E. , Huélamo N. , Deleuil M. , Demangeon O. D. S. , Figueira P. , Grouffal S. , Aceituno J. , Azzaro M. , Bergond G. , Fernández-Martín A. , Galadí D. , Gallego E. , Gardini A. , Góngora S. , Guijarro A. , Hermelo I. , Martín P. , Mínguez P. , Montoya L. M. , Pedraz S. , Vico Linares J. I.
Published: September 2022

The detection of habitable worlds is one of humanity’s greatest endeavors. Thus far, astrobiological studies have shown that one of the most critical components for allowing life to develop is liquid water. Its chemical properties and its capacity to dissolve and, hence, transport other substances makes this constituent a key piece in this regard. As a consequence, looking for life as we know it is directly related to the search for liquid water. For a remote detection of life in distant planetary systems, this essentially means looking for planets in the so-called habitable zone. In this sense, K-dwarf stars are the perfect hosts to search for planets in this range of distances. Contrary to G-dwarfs, the habitable zone is closer, thus making planet detection easier using transit or radial velocity techniques. Contrary to M-dwarfs, stellar activity is on a much smaller scale, hence, it has a smaller impact in terms of both the detectability and the true habitability of the planet. Also, K-dwarfs are the quietest in terms of oscillations, and granulation noise. In spite of this, there is a dearth of planets in the habitable zone of K-dwarfs due to a lack of observing programs devoted to this parameter space. In response to a call for legacy programs of the Calar Alto observatory, we have initiated the first dedicated and systematic search for habitable planets around these stars: K-dwarfs Orbited By habitable Exoplanets (KOBE). This survey is monitoring the radial velocity of 50 carefully pre-selected K-dwarfs with the CARMENES instrument over five semesters, with an average of 90 data points per target. Based on planet occurrence rates convolved with our detectability limits, we expect to find 1.68 ± 0.25 planets per star in the KOBE sample. Furthermore, in half of the sample, we expect to find one of those planets within the habitable zone. Here, we describe the motivations, goals, and target selection for the project as well as the preliminary stellar characterization.
Guttiferone E Displays Antineoplastic Activity Against Melanoma Cells
Authors: Ribeiro Arthur Barcelos , Nicolella Heloiza Diniz , da Silva Lucas Henrique Domingos , Mejía Jennyfer Andrea Aldana , Tanimoto Matheus Hikaru , Ambrósio Sérgio Ricardo , Bastos Jairo Kenupp , Orenha Renato Pereira , Parreira Renato Luis Tame , Tavares Denise Crispim
Published: September 2022

Guttiferone E (GE) is a benzophenone found in Brazilian red propolis. In the present study, the effect of GE on human (A-375) and murine (B16-F10) melanoma cells was investigated. GE
significantly reduced the cellular viability of melanoma cells in a time-dependent manner. In addition, GE demonstrated antiproliferative effect, with IC50 values equivalent to
9.0 and 6.6 µM for A-375 and B16-F10 cells, respectively. The treatment of A-375 cells with GE significantly increased cell populations in G0/G1 phase and decreased those in G2/M phase.
Conversely, on B16-F10 cells, GE led to a significant decrease in the populations of cells in G0/G1 phase and concomitantly an increase in the population of cells in phase S. A significantly
higher percentage of apoptotic cells was observed in A-375 (43.5%) and B16-F10 (49.9%) cultures after treatment with GE. Treatments with GE caused morphological changes and significant
decrease to the melanoma cellsʼ density. GE (10 µM) inhibited the migration of melanoma cells, with a higher rate of inhibition in B16-F10 cells (73.4%) observed. In addition, GE
significantly reduced the adhesion of A375 cells, but showed no effect on B16-F10. Treatment with GE did not induce changes in P53 levels in A375 cultures. Molecular docking calculations
showed that GE is stable in the active sites of the tubulin dimer with a similar energy to taxol chemotherapy. Taken together, the data suggest that GE has promising antineoplastic potential
against melanoma.
Steroidal Saponins from the Rhizomes of Smilax china and Their Inhibitory Effects on Lipopolysaccharide-Induced Proinflammatory Cytokines Expression
Authors: Li Yu-Ting , Feng Xiao , Feng Yunjiang , Cheng Yuanyuan , Tian Li-Wen
Published: September 2022

Four new furostanol saponins (1 – 4) and a new pregane-type saponin (5) along with six known steroidal saponins (6 – 11) were isolated from the rhizomes
of Smilax china. The structures of 1 – 5 were elucidated by extensive analysis of NMR and HR-ESI-MS data in addition to enzymatic hydrolysis and other chemical methods.
Compounds 1, 4, and 11 showed inhibitory activity against the expression of proinflammatory mediators, inducible nitric oxide synthase, interleukin-1β, interleukin-6,
and tumor necrosis factor-α in lipopolysaccharide-induced RAW264.7 cells. Compound 1, at a concentration of 20 µM, decreased the production of inducible nitric oxide synthase,
interleukin-1β, interleukin-6, and tumor necrosis factor-α by 36, 62, 72, and 67%, respectively, which is comparable to that of the positive control dexamethasone.
Entwicklungen, Herausforderung und Perspektiven des Handheld-Ultraschalls (HHUS)
Authors: Dietrich Christoph F. , Bulla Peter , Dudwiesus Heiko , Lo Hendra , Hocke Michael , Hoffmann Beatrice , Horn Rudolf , Lehmann Beat , Morf Susanne , Nuernberg Dieter , Prosch Helmut , Serra Andreas , Spengler Jörg , Blaskova Andrea , Jenssen Christian
Published: September 2022

Es wird der Einsatz von Handheld-Ultraschallgeräten unter technischen und datenschutzrechtlichen Gesichtspunkten, Geräteeigenschaften, Funktionalität, Dokumentation, Indikationen, Delegation der Leistung, Anwendungen durch Ärzte, Studierende und nichtärztliches Personal beleuchtet und diskutiert.
Artificial Intelligence in Oncological Hybrid Imaging
Authors: Feuerecker Benedikt , Heimer Maurice M. , Geyer Thomas , Fabritius Matthias P , Gu Sijing , Schachtner Balthasar , Beyer Leonie , Ricke Jens , Gatidis Sergios , Ingrisch Michael , Cyran Clemens C
Published: September 2022

Background Artificial intelligence (AI) applications have become increasingly relevant across a broad spectrum of settings in medical imaging. Due to the large amount of imaging data that is generated in oncological hybrid imaging, AI applications are desirable for lesion detection and characterization in primary staging, therapy monitoring, and recurrence detection. Given the rapid developments in machine learning (ML) and deep learning (DL) methods, the role of AI will have significant impact on the imaging workflow and will eventually improve clinical decision making and outcomes.

Methods and Results The first part of this narrative review discusses current research with an introduction to artificial intelligence in oncological hybrid imaging and key concepts in data science. The second part reviews relevant examples with a focus on applications in oncology as well as discussion of challenges and current limitations.

Conclusion AI applications have the potential to leverage the diagnostic data stream with high efficiency and depth to facilitate automated lesion detection, characterization, and therapy monitoring to ultimately improve quality and efficiency throughout the medical imaging workflow. The goal is to generate reproducible, structured, quantitative diagnostic data for evidence-based therapy guidance in oncology. However, significant challenges remain regarding application development, benchmarking, and clinical implementation.

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Citation Format
Ärztliche Führung im Krankenhaus der
Zukunft
Authors: Balling Stephan , Bohnet-Joschko Sabine
Published: September 2022

Zielsetzung Wir untersuchen, welche Kompetenzen für
ärztliche Führungskräfte im Krankenhaus der Zukunft
relevant sind.

Methodik Einschätzungen von Akteuren und Stakeholdern aus dem
Gesundheitswesen wurden in einem qualitativen Design durch Experteninterviews
erhoben.

Ergebnisse Medizinische Fachlichkeit dominiert bei der Besetzung
ärztlicher Führungspositionen. Analytisches und strategisches
Denken, Organisationstalent und Entscheidungsfreude,
Kommunikationsfähigkeit, Verständnis für
betriebswirtschaftliche Zusammenhänge, Wissen zu Versorgungssystemen und
Ethik sowie Veränderungs- und Digitalkompetenz gewinnen an
Bedeutung.

Schlussfolgerung Gute ärztliche Führungskräfte
sind kommunikativ stark, Visionäre und Leitbildgeber und bringen die
Fähigkeit zur Veränderung mit. Besondere technische
Fähigkeiten wie Programmiersprachen sind hingegen nicht bedeutend.
Do First-Trimester Subchorionic Hematomas Affect Pregnancy
Outcomes?
Authors: Elmas Burak , Özgü Burçin Salman , Zorlu Uğurcan , Koç Bergen Laleli , Ozdemir Eda Ureyen , Akkaya Selver Kübra , Akay Arife , Öztürk Neslihan , Erkaya Salim
Published: September 2022

Objective The aim of this study is to investigate the relationship between
first trimester subchorionic hematomas and pregnancy outcomes in women with
singleton pregnancies.

Material and methods Between January 2018 and January 2019, patients who
had a single pregnancy between the 6th and 14th weeks of their pregnancy and
were hospitalized with the diagnosis of abortus imminens in the early pregnancy
service were included in the study. According to the ultrasonographic
examination, those with subchorionic hematoma and those with no hematoma were
compared in terms of demographic data, pregnancy outcomes and pregnancy
complications.

Results 400 abortus immines cases with subchorionic hematoma and 400
abortus imminens cases without subchorionic hematoma were compared. Preterm
delivery percentages were similar in both groups, however abortus percentage was
significantly higher in the hematoma group (34.2 vs. 24.7%;
p=0.007). In addition, it was revealed that the presence of subchorionic
hematoma before the 20th gestational week increased the risk of miscarriage 1.58
times. However, no data could be found in the study that could correlate the
size of the hematoma with pregnancy loss.

Conclusion The presence of subchorionic hematoma increases abortion rates
in abortus imminens cases. And the presence of subchorionic hematoma in cases
with ongoing pregnancy does not increase the complications of delivery.
Neonatal Outcomes since the Implementation of No Routine Endotracheal Suctioning of Meconium-Stained Nonvigorous Neonates
Authors: Sheikh Mehwish , Nanda Vishakha , Kumar Rajeev , Khilfeh Manhal
Published: September 2022

Objective This study aimed to evaluate the effect of the 2015 Neonatal Resuscitation Program recommendations of no routine endotracheal suctioning for nonvigorous neonates on the incidence of meconium aspiration syndrome (MAS) and death. We hypothesized that the revised guidelines have not changed the outcome of MAS/death.

Study Design This was a single-center retrospective cohort study. We recorded data on nonvigorous neonates born at gestational age > 37 weeks, who were divided into period 1, n = 95 (before the new guidelines, January 1, 2013–December 31, 2015) and prospective period 2, n = 91 (after the implementation of new guidelines, January 1, 2017–December 31, 2020). Primary outcomes included MAS and death. Secondary outcomes included respiratory neonatal intensive care unit (NICU) admission, length of NICU stay, and feeding difficulties.

Results No significant differences in the occurrence of MAS (11 vs. 17%) (odds ratio [OR] of 1.46 [95% confidence interval [CI]: 0.59–3.55]) or death (1 vs. 3%) (OR of 2.00 [95% CI: 0.18–21.57]) among the two periods were observed. In period 2, there was an increased NICU respiratory admission (37 vs. 61%), with an OR of 2.31 (95% CI: 1.10–4.84). More neonates in period 2 required subsequent intubation for respiratory failure in the delivery room (12 vs. 28%) with an OR of 2.03 (95% CI: 1.02–4.51); p-value of 0.05.

Conclusion Our study did not observe a significant difference in the incidence of MAS or death between the two periods since the 2015 guidelines. However, the incidence of NICU respiratory admission increased.

Key Points