bluuebunny/crossref_metadata_2025 huggingface dataset:
La otra cara de la luna
Authors: Bonilla Heraclio
Published: April 2023

En estos días circula la segunda edición de País de Jauja (Peisa, 1996: 548 pgs.), la aclamada novela de Edgardo Rivera Martínez. Las vivencias y las ilusiones del joven Claudia, en la Jauja de la década de los 40, así como la de sus relaciones sus familiares y otros notables del pueblo, constituyen la trama central de una novela en la cual el paisaje, el lirismo, y el testimonio están permanentemente entrelazados
El honor español en las crónicas americanas de los siglos XVI y XVII
Authors: Fazio Fernández Mariano
Published: April 2023

Uno de los elementos más sobresalientes de la visión del hombre que se tiene en España y en particular en Castilla durante los siglos XVI y XVII es, sin duda, el del honor. Estamos en pleno periodo renacentista, en el que se subraya la importancia de la individualidad.
Racismo, discriminación y acciones afirmativas : herramientas conceptuales
Authors: Segato Rita Laura
Published: April 2023

Cuando decimos u oímos hablar de racismo, tenemos una idea del conjunto de actitudes y acciones a los que esta palabra suele estar asociada. Sin embargo, una mirada de mayor aproximación (más analítica) nos llevará ciertamente a percibir que dicho término engloba en sí una variedad de sentidos que vale la pena diferenciar para entender mejor los procesos involucrados y, de esa forma, podernos defender mejor de sus consecuencias. Una definición jurídica que hoy puede ser considerada como marco para la comprensión y la denuncia es la que formula la Convención Internacional para la Eliminación de todas las formas de Discriminación Racial (CERD), de las Naciones Unidas. Esta convención fue adoptada por la Asamblea General de la ONU en 1965 y se encuentra vigente desde 1969. La CERD define la discriminación racial como: cualquier distinción, exclusión, restricción o preferencia basada en raza, color, descendencia u origen nacional o étnica que tenga el propósito o el efecto de anular o perjudicar el reconocimiento, gozo o ejercicio en pie de igualdad de los derechos humanos y de las libertades fundamentales.
La crisis mundial de 1929 y la economía peruana
Authors: Contreras Carlos
Published: April 2023

El propósito de este texto es revisar, sobre la base de la bibliografía y la información estadística disponible, el impacto que las grandes crisis económicas internacionales tuvieron sobre la vida peruana. Nos hemos centrado en la crisis de 1929, pero a modo de antecedente reseñamos también las crisis de 1873 y 1893, que fueron muy importantes en la configuración del Estado en el Perú y su manera de relacionarse con la economía
Crisis internacional e integración regional
Authors: Fairlie Reinoso Alan
Published: April 2023

La crisis internacional encuentra a la Comunidad Andina en un momento de extrema polarización, tanto por factores internos como por las diferentes concepciones de inserción internacional que agudizaron el problema. En el primer capítulo de este trabajo se reflexiona sobre el estado de la integración andina anterior a la crisis internacional y sobre las diferentes implicancias que el TLC con EE.UU. y el acuerdo de asociación con la Unión Europea han tenido sobre la integración regional. También se revisan otros acuerdos comerciales regionales suscritos o en negociación, contrastándolos con los anteriores. La segunda sección del capítulo analiza el comercio intrarregional antes y después de la crisis. En la tercera, se hace un balance de las respuestas de política comercial que han adoptado los socios. No se encuentra un patrón anticíclico, y las políticas de respuesta de los países más afectados están agravando aún más la situación. En el segundo capítulo se reflexiona sobre algunos escenarios probables definidos por la interacción de la crisis internacional con los factores anteriormente mencionados. Se le da un peso importante a las variables y conflictos políticos y se plantea la ruptura de la CAN como un escenario que paulatinamente adquiere mayor probabilidad. Por último, en el tercer capítulo se reflexiona sobre las reacciones andinas ante la crisis internacional y sobre las posibles consecuencias que esta tendría en la CAN.
Informe etnográfico de Collaguas (1974-1975)
Authors: Cuadros Juan José
Published: April 2023

En el presente trabajo queremos ofrecer algunas evidencias sobre una investigación antropológica, en proceso, para el estudio de un nuevo caso de «verticalidad» en los Andes. Su modalidad para el período prehispánico, así como también sus transformaciones posteriores, aún no ha sido totalmente delimitada (Pease, este volumen). En este sentido, nuestra intención es mencionar algunos datos aislados sobre la «verticalidad» actual en esta región.
Buscando entender la evolución de los indicadores laborales en Bolivia, Paraguay y Perú
Authors: Berry Albert
Published: April 2023

La preocupación básica de este volumen es el diseño de un paquete de políticas capaz de producir buenos resultados en los mercados de trabajo (o sea, una buena evolución de las variables laborales salarios, tasas de empleo, etc.) en Bolivia, Paraguay y Perú
Oferta y demanda de trabajo en la pequeña agricultura : una mirada a la situación rural del Perú rural
Authors: Díaz Ramón
Published: April 2023

El capítulo que presentamos a continuación reporta los principales resultados del estudio desarrollado por un equipo del IEP en el marco del proyecto «Empleo e Ingreso en Bolivia, Paraguay y Perú», auspiciado por IDRC. En este proyecto de investigación, el caso peruano fue analizado desde tres entradas complementarias: una macro, orientada a presentar una mirada de los cambios en los mercados laborales y su relación con el programa de ajuste estructural y con el relativamente largo proceso de crecimiento económico.
Tratamiento jurídico del recurso tierra
Authors: Andaluz Carlos
Published: April 2023

Creemos oportuno, antes de aventurar una definición, establecer la diferencia entre suelo y tierra. En realidad, entre el primero y la segunda existe una relación de género a especie. Así, se considera suelo a toda superficie terrestre, a todo espacio capaz de servir de soporte a los cuerpos que son atraídos por la fuerza gravitacional. El concepto de tierra, por su lado, está referido únicamente a aquel suelo con aptitud para el cultivo y la ganadería; presupone un suelo vivo, es decir, fértil. Se dice que es un suelo vivo porque la fertilidad está dada por la flora y la fauna microbiana; también se le conoce como suelo orgánico.
El Derecho internacional del medio ambiente, el principio precautorio y la sentencia de la Corte Internacional de Justicia sobre los ensayos nucleares en el Pacífico Sur
Authors: Vera Esquivel Germán
Published: April 2023

Para analizar los temas objeto de la reflexión de este artículo, en la primera parte de este documento analizaremos el contenido del principio precautorio como uno de los más novedosos principios a nivel nacional e internacional sobre el medio ambiente. Asimismo, en un segundo momento evaluaremos la validez jurídica de las pruebas nucleares junto con una evaluación inicial del reciente fallo de la Corte Internacional de Justicia sobre el caso de las pruebas nucleares francesas; para finalmente ofrecer algunas conclusiones, en nuestro estilo, siempre preliminares.
Castigos de la naturaleza como actos jurídicos y ecológicos : reflexiones a partir de la experiencia de los Aymaras del Sur andino
Authors: Peña Jumpa Antonio
Published: April 2023

Los Aymaras del Sur Andino del Perú, como ocurre con los quechuas de la misma región y de las poblaciones de los Andes en general, comparten una particular relación con su medio, y, específicamente, la naturaleza que los rodea. Nos interesa reflexionar sobre ese tipo de relación teniendo en cuenta el enfoque de lo Jurídico y lo Ecológico. Los «castigos de la naturaleza como consecuencia de actos humano» constituyen una de las prácticas más controvertidas visto desde la epistemología occidental, al extremo de poder identificarse como «irracional». Sin embargo, dentro de la concepción de los aymaras, tal práctica tiene una gran importancia jurídica y ecológica, en tanto a través de dicha práctica consiguen, principalmente, sancionar los «malos» actos denominados «inmorales» y reforzar la protección de sus recursos.
La deducción por inversiones para la protección del medio ambiente en el Impuesto sobre Sociedades en España
Authors: Bokobo Moiche Susana
Published: April 2023

La sensibilización social generalizada por los temas ambientales, y en concreto, por la consecución del objetivo de protección de nuestro entorno, ha movido a las diferentes Administraciones a adoptar medidas en diversos campos. Estas medidas fueron inicialmente represivas o limitativas de los usos que hacemos los particulares y están fundamentalmente contenidas en la normativa administrativa y penal. En el último lustro la balanza se inclina hacia el establecimiento de medidas estimuladoras que cambien el comportamiento de los productores y /o consumidores. Se comienza ha utilizar otro tipo de instrumentos dentro de los cuales se encuentran los fiscales.
Narrar la ciudad: experiencia y apropiación videolúdica del ciclista urbano en YouTube
Authors: Moreno Reina Daniel , Cubides Serrano Edwin
Published: April 2023

Desde la implementación de las primeras ciclorrutas en Bogotá, Colombia, a inicios de la década del 2000, la bicicleta se convirtió progresivamente en una alternativa de movilidad frente al transporte masivo. Si bien los corredores viales son, a menudo, un escenario de conflicto y de caos, estos también son lugares de expresión que dejan ver las formas de vida en la ciudad allí donde ocurren los desplazamientos. Este artículo de reflexión busca hacer la revisión de algunas expresiones videográficas que narran la ciudad desde los recorridos en bicicleta que se publican en YouTube. Estas creaciones construyen valores y representaciones de ciudad desde la creatividad, el juego y la lúdica; y, a su vez, demuestran apropiaciones narrativas y afectivas del espacio urbano en prácticas de movilidad convencionales e institucionalizadas, o disruptivas y transgresoras del espacio público.
Química bioortogonal: cuando los organismos vivos se convierten en matraces de reacción
Authors: Idiago-López Javier , De la Fuente Jesus M. , Fratila Raluca Maria
Published: April 2023

En este artículo se introducen los conceptos de química “click” y química bioortogonal, que han recibido el Premio Nobel de Química 2022 por sus numerosas ventajas (sencillez, robustez, rendimientos prácticamente cuantitativos, etc.). Se describen en detalle las principales reacciones bioortogonales, las cuales se pueden llevar a cabo en sistemas vivos, como células e incluso animales, que se convierten en exóticos “matraces de reacción”. También se proporciona una visión general de los últimos avances en bionanomedicina, surgidos gracias a la combinación de la química bioortogonal con las propiedades únicas de los nanomateriales. Para ello, se presentan las principales características de los nanomateriales y describen algunos estudios recientes relacionados con el desarrollo de nuevas herramientas de imagen y terapia.
Fixed-ratio Combinations (basal Insulin Plus GLP-1RA) In Type 2 Diabetes. an Analytical Review Of Pivotal Clinical Trials
Authors: Vargas-Uricoechea Hernando , Frias Juan Pablo , Vargas-Sierra Hernando David
Published: April 2023

In type 2 diabetes, therapeutic failure to the oral anti diabetics is frequent, the use of schemes with basal insulin or with multiple doses of insulin (basal insulin and short-acting insulins) are a widely accepted way to intensify therapy. The use of GLP-1 receptor agonists is another
intensification strategy. The fixedratio combinations with molecules such as insulin degludec + liraglutide, and insulin glargine + lixisenatide have proven useful in intensifying treatment of individuals with type 2 diabetes. The purpose of this review was to evaluate and analyze the results
of pivotal studies with both fixed-ratio combinations in individuals with type 2 diabetes, finding that, they are capable of achieving better glycemic control when compared with each of its components separately (with a lower risk of hypoglycemia vs basal insulin and lower risk of gastrointestinal
adverse effects vs GLP-1 receptor agonists) in various clinical scenarios, especially in individuals who do not achieve control with oral antidiabetics or who do not achieve control with basal insulin (associated with oral antidiabetics) or in those under management with GLP-1RA plus oral
antidiabetics.
A Clinical and Biochemical Comparative Study Of Diabetic Ketoacidosis (DKA) in Newly Diagnosed Vs Known Cases of Type 1 Diabetic Children
Authors: Albuali Waleed H. , Yousef Abdullah A. , Al-Qahtani Mohammad H. , AlQurashi Faisal O. , Albuali Hamad W. , Yousef Haneen A. , Aldajani Ala'a A. , Ghamdi Mohammed A.Al , AlBassam Bassam N.
Published: April 2023

Objectives: We aimed to study the characterizing clinical and biochemical profiles of Diabetic Ketoacidosis (DKA) in children with newly diagnosed Type 1 Diabetes Mellitus (Type 1DM) compared to children with established diagnosis of Type 1DM presenting with DKA admitted to the
pediatric intensive care unit of a large university hospital in the eastern region of Saudi Arabia. Methods: We retrospectively reviewed the medical records of 211 patients who were admitted to the pediatric intensive care unit with diabetic ketoacidosis between 2010 and 2019. The diagnosis
of diabetic ketoacidosis was based on symptoms of polydipsia, polyurea, weight loss, vomiting, dehydration, abdominal pain, breathing problems, lethargy or coma, biochemical hyperglycemia (blood glucose level of >200 mg/dL), venous pH of <7.3, serum bicarbonate level of ≤15 mEq/L,
and ketonemia (blood β -hydroxybutyrate concentration of ≥3 mM) or moderate or severe ketonuria (diagnosed as newly acquired type 1 diabetes). Results: The rate of newly diagnosed Type 1 DM with DKA was 41.7%, out of them who got severe and moderate diabetic ketoacidosis were
61.6% and 38.4%, respectively. We observed significantly increased heart and respiratory rates in patients newly diagnosed with diabetic ketoacidosis and in those with severe diabetic ketoacidosis (p<0.001) compared to known cases with Type 1DM presenting with DKA. We also identified significantly
increased biochemical indices including HbA1c, random blood sugar, serum osmolality, blood urea nitrogen, creatinine, chloride, lactate, and anion gap in relation to severe diabetic ketoacidosis and newly diagnosed type 1 diabetes (p ≤ 0.05). Conclusions: We found that the clinical
and biochemical profiles of patients with newly diagnosed Type 1 DM children were significantly affected compared to children who were known Type 1DM presenting with DKA.
Bayes' approach of linear regression to modeling the human development index in Indonesia
Authors: Fazriwanandi Achmad , Nohe Darnah Andi , Wasono Wasono
Published: April 2023

Regression analysis is one of the data analysis techniques that can be used to examine the correlation between two variables, namely dependent variable and independent variable. It’s can be used to determine the parameter estimation of linear regression models are; the method of least squares or ordinary least square (OLS), Maximum likelihood estimation (MLE), and the Bayes method. Bayes' method defines the parameter as a random variable that describes the initial comprehension of the parameter before the observation was initiated and elucidated in an initial distribution refer as the prior distribution. The prior distribution used in this study is the pseudo prior distribution. The Data used in this study is secondary data, namely human development index (HDI) data in 2020, which was obtained from the website of the Central Statistics Agency (BPS). This study aims to estimate the regression model parameters using the Bayes method on the HDI data and the population data which adepts with information and communication technology (ICT) in Indonesia in 2020. The results of the specimen and analysis showed that population variables with ICT adepts have a significant effect on HDI variables. The results of the determination coefficient showed that 78.42% of HDI variables are affected by the population variables with ICT adepts while the remaining 21.58% are affected by other factors that have not been studied.

Keywords: Bayes method, human development index, information communication and technology, linear regression, pseudo prior.MSC2020: 62F15
Analisis regresi data panel terhadap indeks pembangunan manusia (IPM) kabupaten/kota di Jawa Timur tahun 2017-2021
Authors: Nikmah Ifadhotun
Published: April 2023

The Human Development Index (HDI) is one of the main performance indicators that becomes a benchmark for the success of human development which consists of the dimensions of education, health and per capita expenditure. The government's role is very strategic in determining development priorities to realize an improved human development index. The purpose of this researchwas to determine the effect of the variables of Poverty Level, Economic Growth and GRDP per Capita on the Human Development Index (HDI) in 38 Regencies/Cities in East Java Province in 2017-2021. The technique used in this research is Panel Data Regression analysis. The result indicate that the Fixed Effect Model (FEM) Cross Section Weight was chosen as the best modelcompared to the Common Effect Model (CEM) and Random Effect Model (REM). Simultaneously, the poverty rate, economic growth and GRDP per capita have a significant effect on the HDI. Partially, poverty level and economic growth have a negative and significant impact on HDI in districts/cities in East Java, while income per capita has a positive and significant impact on HDI. Economic growth has a negative effect on HDI due to a contraction in economic growth to minus in 2021 due to the Covid-19 pandemic.The variable that has the most influence on the HDI is the poverty rate

Keywords: HDI, panel data regression, fixed effect model cross section weightMSC2020: 62J05
Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model
Authors: Kim Kibong , Lee Kang Pa , Beak Suji , Park Sunyoung , Kim Jisu , Ahn Sang Hyun
Published: April 2023

[Purpose] Excessive exercise causes various gastric dysfunction. Gastritis is common among athletes who perform high-intensity training. Gastritis is a digestive disease involving mucosal damage caused by inflammatory reactions and oxidative stress. In this study, the effects of a complex natural extract on gastric mucosal damage and the expression of inflammatory factors were evaluated in an animal model of alcohol-induced gastritis.[Methods] A mixed herbal medicine (Ma-al-gan; MAG) was prepared with four natural products (Curcumae longae Rhizoma, Schisandrae chinensis Fructus, Artemisiae scopariae herba, and Gardeniae Fructus) identified by a systemic analysis using the Traditional Chinese Medicine Systems Pharmacology platform. The effects of MAG on alcohol-induced gastric damage were evaluated.[Results] MAG (10–100 μg/mL) significantly reduced the mRNA and protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells. MAG (500 mg/kg/d) effectively prevented alcohol-induced gastric mucosal injury in vivo.[Conclusion] MAG regulates inflammatory signals and oxidative stress and is a potential herbal medicine for gastric disorders.
Reliability and validity of the 21-m shuttle-run test and its application to youth soccer players during the preseason training
Authors: Byun Kyeongho
Published: April 2023

[Purpose] This study has two purposes: first to assess the reliability and validity of the 21-m shuttle-run test (21-m SRT) and, second, to evaluate the practicality of the 21-m SRT for youth soccer players during preseason training.[Methods] Twenty-seven youth soccer players (15.9 ± 0.7 yrs., males) participated in the present study. To assess the reliability of the test, each player performed the 21-m SRT twice, on separate days. Criterion validity of the 21-m SRT was determined by examining the relationship between directly measured V3 O2max and 21-m SRT performance. To test the practicality of the 21-m SRT, three 21-m SRTs and two graded exercise tests on a treadmill were performed by each youth soccer player during preseason training.[Results] Results revealed that the 21-m SRT has high correlation coefficients (r = 0.87) between test and retest and has moderate correlation coefficients (r = 0.465) between V3 O2max and SRT performance. As V3 O2max significantly increased after the training period, SRT performance (distance and heart rate immediately after the 67th shuttle run) also positively changed during the preseason training period.[Conclusion] The 21-m SRT has high reliability with moderate validity, and it is an effective tool for coaches to examine aerobic capacity and the efficacy of a training program for youth soccer players during the preseason training period.
Total energy expenditure of collision team sports players measured using doubly labeled water: a systematic review
Authors: Kim Nahyun , Park Jonghoon
Published: April 2023

[Purpose] Total energy expenditure (TEE) is crucial for energy balance and recovery in athletes who participate in collision team sports with high training volumes. This study aimed to review the existing evidence on TEE measured using the doubly labeled water (DLW) technique in soccer, basketball, and rugby players. Furthermore, this systematic review summarized the training volume, match details during the measurement period, and body composition of the athletes.[Methods] This systematic review used the PubMed, Science Direct, Web of Science, and Embase databases. Only articles presenting objectively measured data on the TEE of adolescent and adult collision team sports players were included, as measured using the DLW method. The measurement period, training, match information, and body composition data were also obtained. The search strategy identified 1497 articles, of which 13 met the selection criteria.[Results] The 13 studies included four rugby players, six soccer players, and three basketball players; six of the 13 studies involved young players. The TEE measured using the DLW method was 3862.3–5783.9 kcal/day for rugby, 2859–3586 kcal/day for soccer, and 4006–4921 kcal/day for basketball players.[Conclusion] The TEE of collision sports players varies depending on the training or match load, body composition, and measurement period. Individual approaches to nutritional prescriptions for collision sports players should also account for different periods, anthropometric profiles, training, and game loads. This review provides evidence for developing nutritional guidelines to optimize the recovery and performance of collision team players.
Low-pressure-driven barocaloric effects at colinear-to-triangular antiferromagnetic transitions in Mn3-xPt1+x
Authors: Zhao Xueting , Zhang Kun , Qi Ji , Liu Peng , Zhang Zhao , Qu Lin , Zhang Zhidong , Li Bing
Published: April 2023

A large driving pressure is required for barocaloric effects (BCEs) in intermetallics, usually above 100 MPa. Here, we report barocaloric effects in Mn3-xPt1+xalloys saturated at about 60 MPa, the lowest pressure reported in intermetallics to date. A first-order phase transition occurs from the colinear antiferromagnetic phase to the triangular antiferromagnetic phase as temperature decreases. The transition temperature strongly depends on the composition x, ranging from 331 K for x = 0.18 to 384 K for x = 0.04, and is sensitive to pressure, with dTt/dP up to 139 K/GPa. However, the maximum pressure-induced entropy changes are as small as 13.79 J kg-1 K-1, attributed to the mutual cancellation of lattice and magnetic entropy changes. The small driving pressure and total entropy changes are due to the special magnetic geometric frustration.
The Pecking Order Theory Perspective in the Study of Company Capital Structure (Study On Manufacturing Companies On The Indonesia Stock Exchange)
Authors: Oktaviyanti Ika , Sumartik Sumartik
Published: April 2023

A balanced combination of own capital and debt is the main key to optimal capital structure in a corporation. At any given time, the management team in the company will show you a targeted capital structure, which may be optimal, althought that target may change from time to time. Several factors influence the company’s capital structure decisions such as Profitability, Liquidity and Company Size. This study was used to measure the impact of profitability, liquidity and firm size on the capital structure of manufacturing companies on the Indonesian stock exchange for the period 2018-2021 using the pecking order theory method. The population used in this study is manufacturing companies listed on the Indonesia Stock Exchange. Sampling method used targeted sampling method and obtained his 40 samples from Indonesian Stock Exchange-listed manufacturing companies in the period 2018-2021. Analysis of the data used is multiple linear regression analysis using the SPSS application. Simultaneously the results obtained from this study are the variables of Profitability, Liquidity and Company Size have a significant effect on Capital Structure.
Bureaucratic Culture, Ethical Leadership, and Communication in LLDIKTI Region VII, Indonesia
Authors: Tistasari Rachma
Published: April 2023

This study investigates the impact of bureaucratic culture, ethical leadership, and communication climate on the performance of LLDIKTI Region VII civil servants, a key institution under the Indonesian Ministry of Education and Culture responsible for managing private universities in a specific region. A total of 80 civil servants participated as respondents. Data were collected using questionnaires and analyzed through Structural Equation Modeling-Partial Least Squares (SEM-PLS). The findings reveal that bureaucratic culture and ethical leadership significantly and positively influence the performance of LLDIKTI Region VII civil servants. Furthermore, communication climate moderates the relationships between both bureaucratic culture and ethical leadership, and civil servant performance. The results highlight the importance of fostering positive bureaucratic culture, promoting ethical leadership, and nurturing a healthy communication climate to enhance performance in private university management. These findings have implications not only for the Indonesian context but also for similar organizations globally, emphasizing the need to explore the generalizability of these results and investigate additional moderating factors that may influence organizational culture, leadership, and performance.
Plan de negocio para la comercialización online de comida de perros a base de cascarilla de arroz en Lima Moderna 2022
Authors:   , Abanto Leiva José Miguel , Antay Anca Mirian Fiorela , Esaine Estremadoyro María del Carmen , Fernandez Palomino Flor de Liz
Published: April 2023

NUTRIPET FOOD es un ecommerce, un emprendimiento que se origina en base a un estudio realizado por un equipo de trabajo, se va centrar en cubrir una exigencia actual que hay en el segmento de las operaciones de compra y venta online, esta iniciativa tiene que ver con comerciar comestible para perros de raza pequeña. Nuestros clientes son personas que tienen el hábito de demandar productos que tengan una alta calidad para otorgarles buenos alimentos a sus perritos ya que los consideran integrantes de su hogar, para esto se han usado herramientas que sirven para hacer medidas (entrevistas y encuestas) y esto nos va a ayudar a armonizar las posibilidades de nuestra idea y confirmar las hipótesis que se han planteado. Con el fin de decretar la viabilidad de nuestro plan estratégico, se realizó una validación en el mercado, para conocer el perfil del comprador con el objetivo de determinar quiénes serían los principales clientes de nuestra propuesta comercial. La presente labor se dirige a cubrir aquellas exigencias particulares en un segmento del mercado, ya que, en muchos aspectos, ubican únicamente productos básicos que no son del gusto de sus perritos o sus necesidades. Nuestra propuesta es una opción más que busca cobertura una demanda no cubierta en el emporio.
Corredor verde para la interpretación, agricultura urbana e investigación en las Lomas de Paraíso. Servicios ecosistémicos afectados por el fenómeno de dispersión urbana en las Lomas de Paraíso
Authors:   , Tocto Chavez Yessica Edith , Rodríguez Criollo Miguel Esteban
Published: April 2023

Siendo las lomas costeras, ecosistemas frágiles pertenecientes a la estructura ecológica de Lima, constituyen un componente clave en el aporte ambiental, cultural y el potencial turístico, recreativo y educativo que pueden ofrecer a la ciudad y a sus habitantes. Esta investigación presenta los resultados de un estudio enfocado en las Lomas de Paraíso en el distrito de Villa María del Triunfo, un ecosistema frágil amenazado por la actividad antropogénica no regulada e informal; analizando cómo afecta el fenómeno de dispersión urbana a los servicios ecosistémicos entre los años 2000 – 2020 y cómo estos se han visto deteriorados y disminuidos a lo largo de este periodo. La recolección de información se realizó mediante encuestas, entrevistas e imágenes satelitales. Los resultados demuestran la disminución de la superficie de lomas a causa de la dispersión urbana, afectando así a los servicios ecosistémicos de provisión, regulación y culturales. Se concluye que, es necesario establecer un límite permeable para evitar la dispersión urbana en las lomas y que además, sea capaz de generar nuevas dinámicas urbanas a su alrededor, priorizando la valoración y conservación de los servicios ecosistémicos para los habitantes y para la ciudad, concretando así la propuesta de un corredor verde para la interpretación, agricultura urbana e investigación; que mejora la calidad de vida de la población y la protección de las lomas.
Fitorremediación de pasivos mineros con Polylepis sp. en sinergia con Arthrobacter luteolus, Pseudomonas extremaustralis y Stenotrophomonas rhizophila en la unidad minera Sumaq Rumi (Junín - Perú)
Authors:   , Flores Piscoya Gabriela Victoria
Published: April 2023

Los pasivos mineros en el Perú generan desechos y emisiones, muchas veces son concesiones de diferentes empresas mineras que no siguen un adecuado plan de remediación de sus pasivos mineros, y esta tarea pasa a un segundo plano. Es por lo que, ante las normativas ambientales vigentes, es importante contemplar un plan de remediación y cierre de pasivos ambientales mineros que sea efectivo, económico y lo menos invasivo con el medio ambiente. La fitorremediación podría ser una estrategia que cumple con las tres necesidades mencionadas anteriormente. Esta investigación se desarrolló in situ en la minera “Sumaq Rumi” (Junín) con el objetivo de evaluar la eficiencia de la simbiosis planta-microorganismo para optimizar la fitorremediación de Polylepis rodolfo-vasquezii. Se instalaron la parcela control con tierra de la zona y la parcela tratamiento con pasivo minero donde se sembró la especie Polylepis rodolfo-vasquezii, y se inocularon microorganismos nativos aislados de la zona identificados molecularmente (ADN) como Arthrobacter luteolus, Pseudomonas extremaustralis y Stenotrophomonas rhizophila, para evaluar la eficiencia de la simbiosis planta-microorganismo que optimizaría la fitorremediación, se analizó la bioabsorción de As, Ag, Mn, Pb, Zn, Fe, Cu, y otros en la planta y, la acumulación de los mismos en el suelo por técnicas de espectometría. Finalmente se concluyó que Polylepis rodolfo-vasquezii en estado juvenil es potencialmente hiperacumuladora, de bajo costo de crecimiento, fácil adaptación al medio ambiente andino y de gran sinergia junto con la bacteria Stenotrophomonas rhizophila, con la que evidenció mayor absorción de metales en la planta siendo candidata para futuras biorremediaciones de suelos contaminados con pasivos mineros.
New Insights into Hybrid Low-Salinity Polymer Flooding through a Coupled Geochemical-Based Modeling Approach
Authors: Hassan Anas M. , Al-Shalabi Emad W. , Alameri Waleed , Kamal Muhammad Shahzad , Patil Shirish , Hussain Syed Muhammad Shakil
Published: April 2023

Low-salinity polymer (LSP) flooding is a synergic emergent enhanced oil recovery (EOR) technique. Previous laboratory experiments showed noticeable improvements in displacement efficiency, polymer rheology, injectivity, and viscoelasticity. Nevertheless, when it comes to modeling LSP flooding, it is still challenging to develop a mechanistic predictive model that captures polymer-brine-rock (PBR) interactions. Therefore, this study uses a coupled MATLAB reservoir simulation toolbox (MRST)-IPhreeqc simulator to investigate the effect of water chemistry on PBR interactions during LSP flooding through varying overall salinity and the concentrations of divalent and monovalent ions. For describing the related geochemistry, the presence of polymer in the aqueous phase was considered by introducing novel solution species (Poly) to the Phreeqc database. The developed model’s parameters were validated and history matched with experimental data reported in the literature. Moreover, different injection schemes were analyzed, including low-salinity (LS) water, LSP injection (1 × LSP), and 5-times spiked LSP injection (5 × LSP) with their related effects on polymer viscosity.

Results showed that polymer viscosity during LSP flooding is affected directly by Ca2+ and Mg2+ and indirectly by SO42− owing to PBR interactions on a dolomite rock-forming mineral. Monovalent ions (viz. Na+ and K+) have minor effects on polymer viscosity. Ca2+ and Mg2+ ions discharged from dolomite dissolution create polymer complexes (acrylic acid, C3H4O2) to reduce polymer viscosity significantly. The increased SO42− concentration in the injected LSP solution affects the interactions between the polymer and positively charged aqueous species, leading to minimized polymer viscosity loss. For LSP flood derisking measures, the cation’s effect was related to the charge ratio (CR). Thus, it is key to obtain an optimal CR where viscosity loss is minimal. This paper is among the few to detail the mechanistic geochemical modeling of the LSP flooding technique. The validated MRST-IPhreeqc simulator evaluates the previously overlooked effects of water chemistry on polymer viscosity during the LSP process. Using this coupled simulator, several other geochemical reactions and parameters can be assessed, including rock and injected-water compositions, injection schemes, and other polymer characteristics.
Nine golden codes: Improving the accuracy of Helicopter Emergency Medical Services (HEMS) dispatch - a retrospective, multi-organisational study in the East of England
Authors: Edmunds Christopher , Lachowycz Kate , McLachlan Sarah , Downes Andrew , Smith Andrew , Major Rob , Barnard Edward
Published: April 2023

Background
Helicopter Emergency Medical Services (HEMS) are a limited and expensive resource, and should be intelligently tasked. HEMS dispatch was identified as a key research priority in 2011and 2022, with a call to identify a ‘general set of criteria with the highest discriminating potential’. However, there have been no published data analyses in the subsequent decade that specifically address this priority, and this priority has been reaffirmed in 2022. The objective of this study was to define the dispatch criteria available at the time of the initial emergency call with the greatest HEMS utility using a large, regional, multi-organizational dataset in the UK.
Methods
This retrospective observational study utilized dispatch data from a regional emergency medical service (EMS) and three HEMS organisations in the East of England, 2016-2019. In a logistic regression model, Advanced Medical Priority Dispatch System (AMPDS) codes with ≥50 HEMS dispatches in the study period were compared with the remainder to identify codes with high-levels of HEMS patient contact and HEMS-level intervention/drug/diagnostic (HLIDD). The primary outcome was to identify AMPDS codes with a >10% HEMS dispatch rate of all EMS taskings that would result in 10-20 high-utility HEMS dispatches per 24-hour period in the East of England. Data were analysed in R, and are reported as number (percentage); significance was p<0.05.
Results
There were n=25,491 HEMS dispatches (6.4k per year), of which n=23,030 (90.3%) had an associated AMPDS code. n=13,778 (59.8%) of HEMS dispatches resulted in patient contact, and n=8437 (36.6%) had an HLIDD.
43 AMPDS codes had significantly greater rates of patient contact and/or HLIDD compared to the reference group. In an exploratory analysis, a cut-off of ≥70% patient contact rate and/or ≥70% HLIDD (with a >10% HEMS dispatch of all EMS taskings) resulted in 17 taskings per 24-hour period. This definition derived nine AMPDS codes with high HEMS utility.
Conclusion
We have identified nine ‘golden’ AMPDS codes, available at the time of initial emergency call, that are associated with high-levels of whole-system and HEMS utility in the East of England. We propose that UK EMS should consider immediate HEMS dispatch to these codes.
Efficacy of an Aloe Vera, Chamomile, and Thyme Cosmetic Cream for the Prophylaxis and Treatment of Mild Dermatitis Induced by Radiation Therapy in Breast Cancer Patients: a Controlled Clinical Trial Study (Alantel Trials)
Authors: Jimenez-Garcia Celia , De Torres Luis Angel Pérula , Villegas-Becerril Enrique , Muñoz-Gavilan Juan Jose , Espinosa-Calvo Maria , Montes-Redondo Gertrudis , Romero-Rodriguez Esperanza
Published: April 2023

Background: Dermatitis is a skin condition caused by multiple causes, including radiotherapy treatment. Pharmacological treatments can become chronic and are not exempt from side effects. The latest recommendations of the American Academy of Dermatology establish the use of natural, nourishing, and moisturizing cosmetic products as prevention and the first therapeutic step for dermatitis. Alantel® is a cream developed to reduce redness and irritation and promote the local immune system, combat immunosenescence, as well as promote the healing of epidermal lesions. The objective was to evaluate the effect of a cream (Alantel) based on natural products at high concentrations for the preventive and curative treatment (early stages) of radiation-induced dermatitis in patients with breast cancer.
Methods: Our protocol is a experimental, prospective, double-blind, multicenter, controlled clinical trial with two parallel arms. The experimental group will be treated with Alantel while the control group will receive a placebo. Radiotherapy oncology professionals will recruit a total of 88 patients (44 per comparison group) with breast cancer who will receive radiotherapy oncology treatment for 15 days, and they will be randomly assigned to the experimental or control group. Selected patients will be followed for four visits by Primary Care physicians for up to one week after completion of radiotherapy. The main study variable will be the incidence rate of mild post-radiation dermatitis. An intention-to-treat analysis will be performed, applying a comparison test for independent means and proportions. A bivariate and multivariate analysis will also be developed to check the treatment effect, adjusting for predictive sociodemographic and clinical variables.
Discussion: The purpose of this clinical trial is to evaluate the effect of a cream already marketed (Alantel) based on natural products at high concentrations for the preventive and curative treatment (early stages) of radiation-induced dermatitis in patients with breast cancer. The COVID19 pandemic has influenced by delaying the start of the study. One of the main limitations of this study will be the time required to recruit the patients from the planned sample, given that the selection criteria are restrictive and, although the study is multicenter, recruitment is carried out through a single service on radiotheraphy oncology.
Trial registration: The clinical trial has been registered in Clinicaltrials.gov (ref. NCT04116151). Registered on October 4, 2019. https://clinicaltrials.gov/ct2/show/ NCT04116151
Personalized exposure and ESM feedback versus exposure as usual for OCD: a study protocol for a randomized controlled trial
Authors: Hoogerwerf Elena , Greeven Anja , Goekoop Rutger , Spinhoven Philip
Published: April 2023

Background This study aims to compare personalized exposure with response prevention (ERP) using experience sampling methodology-based feedback to ERP as usual in patients with obsessive-compulsive disorder (OCD). Personalized exposure will be provided screen-to-screen in an ecologically valid (real time and real place) context by means of a smartphone application. This app will also be used to collect both objective and subjective data by means of experience sampling methodology (ESM). This ESM-data will be used to identify triggers and protective factors for symptom severity, provide personalized feedback and optimize the effect of ERP. The primary goal of this RCT is to compare the effectiveness of personalized ERP to ERP as usual in the traditional context of a therapist’s room in patients with OCD in OCD symptom severity. Since both self-efficacy and experiential avoidance are known to influence symptom-severity in OCS, a secondary goal is to examine if a possible treatment effect is mediated by self-efficacy or experiential avoidance.
Methods This study involves a randomized controlled trial with 20 weekly sessions by 2 groups (ERP as usual versus personalized ERP), repeated measurements at baseline (T0), 5 weeks of treatment (T1), 10 weeks of treatment (T2), 15 weeks of treatment (T3), posttest at 20 weeks (T4), 6 weeks follow-up (T5), 3 months follow-up (T6), 6 months follow-up (T7) and a year follow-up (T8). A hundred and sixty patients with an OCD diagnosis according to DSM-5 criteria will participate. Half of the group will receive exposure with response prevention as usual, the other half will receive personalized exposure with response prevention with a smartphone application and personalized feedback sessions based on experience sampling data.
Discussion This randomized controlled trial is the first to assess the influence of delivering ERP through video calling and the use of an ESM intervention on the symptom severity of OCD. Since the global pandemic COVID-19, the use of video calling to deliver psychological treatments has become more common, increasing the relevance of this study.
Trial registration: ICTRP Trial NL8254 registered on 2019-12-24 url: https://trialsearch.who.int/Trial2.aspx?TrialID=NL8254
Does energy-environmental efficiency benefit from advanced policy zones? Evidence from national new zones of China
Authors: wu tielong
Published: April 2023

As global climate change aggravates, reducing energy consumption and environmental pollution is essential to sustainable economic development. This paper measures the energy-environmental efficiency of 284 prefecture-level cities in China using a non-radial directional distance function (NDDF) and data envelopment analysis (DEA), and evaluates the impact of the establishment of national new zones on energy-environmental efficiency using the multi-period difference-in-difference model (DID). We find that establishing national new zones improves the energy-environmental efficiency of the prefecture-level cities in which they are located by 13%-25% by enhancing the cities' green technical efficiency and scale efficiency. In addition, national new zones have both negative and positive spatial spillover effects, inhibiting the energy-environmental efficiency of cities within 50 km, and promoting the energy-environmental efficiency of cities around 300 km by a smaller value. In terms of heterogeneity, on the one hand, the impact of establishing national new zones on energy-environmental efficiency increases with larger quantile of the latter; on the other hand, National new zones with the one-city layout have significant stimulating impacts on energy-environmental efficiency, but those with the two-city layout have no significant impact, which means there is no significant green synergistic development impact among cities.
Expression pattern of potential heat stress genes under warm and cold episodes in scleractinian coral ‘Dipsastraea matthaii’ in the hottest sea, ‘the Persian Gulf’
Authors: Shokri Mohammad Reza , Tohidfar Masoud , Moghaddam Sanaz
Published: April 2023

Shallow water reefs are widely threatened by anthropogenic ocean warming which sometimes exceeds their thermal tolerance limit. However, certain hard coral species are thermally resilient and can quickly adapt to anomalous thermal stress events by altering the expression of their heat stress-related genes. A comparative analysis of microarray data was undertaken to identify candidate genes involved in temperature stress. Finally, to validate the results of the analysis, four genes, including [i.e., Cell Division Cycle 16 (CDC16), Ubiquitin C (UBC), Heat Shock Protein 90 Beta Family Member 1 (HSP90B1), Histone acetyltransferase p300 (EP300)] as genes responding to temperature stress in the scleractinian coral “Dipsastera matthaii” collected from the Persian Gulf were selected for real-time PCR during warm and cold periods. Expression changes of them highly confirmed the results of the meta-analysis. So that a significant increase in expression was observed for UBC, HSP90B1, and EP300 in response to heat stress. The EP300 enhancement was triggered by transcription activation through binding to transcription factors. An important feature of this response was the expression of molecular chaperones such as HSP90B1 as a result of activation of the Heat Shock Factor 1 (HSF1). In addition, HSF1 activates UBC, which removes critically digested proteins along the path of the ubiquitin proteolysis system. The outcome of this study could help introduce candidate genes that may be beneficial as biomarkers for selection.
Synthesis of pure and high-quality biodiesel from waste frying oil using CaO prepared from waste coralline sand
Authors: Singh Reena , Pradhan Gitanjali , Pradhan Subhalaxmi , Madhu Devarapaga
Published: April 2023

Biodiesel is projected to replace the conventional diesel which is naturally occurring from a non-renewable resource called petroleum. Biodiesel generally prepared from bioresources and improves rural economy. The present research focuses on synthesis of biodiesel from waste cooking oil using catalyst generated from waste material. Waste coralline sand degraded from parent coral reef rock was used to make high purity and low cost CaO, and used in the production of biodiesel as an effective heterogeneous solid base catalyst. The calcination temperature was held at 800 °C for 3.5 hours, yielding a high purity CaO catalyst. Well-known tools namely XRD, FT-IR, and TGA were employed to characterize the catalyst that was obtained. Elemental analysis and surface morphology were observed with SEM-EDX, respectively. To produce biodiesel, each batch went through a succession of transesterification reactions. Each experiment examined how the co-solvent changed the yield of biodiesel. Biodiesel of high grade and purity was produced and analysed using 1H NMR and FI-IR spectra. There are some variables which adversely affected biodiesel yield, like reaction time, temperature, molar ratio, and concentration of the catalyst. The density, kinematic viscosity, cloud point, and other properties of synthesised biodiesel were investigated using ASTM guidelines. It was established that the developed CaO catalyst was reused up to 5 times without substantially degrading its catalytic activity.