bluuebunny/crossref_metadata_2025 huggingface dataset:
Are Strategies for Women in Compensation Negotiations More Appealing When It Is Explained How They Are Meant to Impact Negotiation Outcomes?
Authors: Lietz Melanie , Mazei Jens , Mertes Marc , Hüffmeier Joachim
Published: October 2022

Women perceive specific strategies developed to support their performance in compensation negotiations as ineffective and are unlikely to use them—suggesting an implementation gap. We examined whether providing theoretical rationales—explaining how specific strategies are meant to work—attenuates this gap. Furthermore, we explored a novel cause of it: women's expectations regarding the perpetuation of gender roles upon using a strategy. In two studies ( N = 1,254), we observed that regardless of the provision of the rationales, women expected all examined specific strategies to be less economically effective and most of them to perpetuate gender roles more than regular assertiveness. Moreover, especially women's expectations regarding economic outcomes decreased their intentions to use most specific strategies. Women also expected most specific strategies to lead to less favorable social evaluations than yielding, which again led to their lower intentions to use them. Altogether, negotiation trainers and educators should consider that explaining how specific strategies are meant to work is not enough to close the implementation gap and to reduce gender inequality in negotiations. To attenuate the implementation gap, they may need to enable women to more fully experience how using specific strategies can improve their negotiation performance. Online slides for instructors who want to use this article for teaching are available on PWQ's website at http://journals.sagepub.com/doi/suppl/10.1177/03616843221128484 .
Breakfast Skipping and Declines in Cognitive Score Among Community-Dwelling Older Adults: A Longitudinal Study of the HEIJO-KYO Cohort
Authors: Ishizuka Rika , Otaki Naoto , Tai Yoshiaki , Yamagami Yuki , Tanaka Kunihiko , Morikawa Masayuki , Iki Masayuki , Kurumatani Norio , Saeki Keigo , Obayashi Kenji
Published: October 2022

Previous studies outlined the correlation of adverse effects of breakfast skipping with cognitive function. However, the majority of these studies have focused on the short-term effects; to date, the long-term effect of breakfast skipping on cognitive function among older adults remains unclear. In this prospective cohort study of 712 older adults (mean age, 70.8 years), breakfast skipping was defined as skipping breakfast one or more times per week, and declines in cognitive score was defined as decreases in Mini-Mental State Examination (MMSE) score of two or more in the observed period. During follow-up (median, 31 months), 135 of 712 participants developed declines in cognitive score. Poisson regression models revealed that the incidence rate for declines in cognitive score was significantly higher in breakfast skipper (n = 29) than breakfast eaters (n = 683) [incidence rate ratio (IRR), 2.10; 95% CI, 1.28-3.44]. Additional propensity score adjustments related to breakfast skipping from baseline parameters (age, gender, smoking and drinking status, BMI, household income, educated level, depressive symptoms, hypertension, diabetes, sleep medication, physical activity, caloric intake, and baseline cognition) produced consistent results (IRR, 2.21; 95% CI, 1.33-3.68). Sensitivity analysis, when the cut-off value of decreases in MMSE score was changed to three points, suggested a significant and stronger association (IRR, 3.03; 95% CI, 1.72-5.35). Regarding daily intakes of food groups, breakfast skippers consumed a significantly lower amount of vegetables, fruits, and fish than breakfast eaters. In conclusion, our findings suggest that breakfast skipping is longitudinally associated with declines in cognitive score among older adults.
Linking Career Adaptability to Entrepreneurial Burnout: A Moderated Mediation Model
Authors: Zhao Haiyuan , Weng Qingxiong , Li Junyi , Gao Wenyang
Published: October 2022

Based on career construction theory and person-environment fit theory, this study developed a theoretical model linking career adaptability to entrepreneurial burnout. A three-wave data collected from 319 owner-manager entrepreneurs showed that career adaptability was positively associated with person-entrepreneurship fit, which negatively related to subsequent entrepreneurial burnout. Moreover, we found that the indirect effect of career adaptability on entrepreneurial burnout was stronger for entrepreneurs with higher (versus low) entrepreneurial role model exposure. By integrating entrepreneurship and career construction literature, this study shows whether, how, and when career adaptability leads to low subsequent entrepreneurial burnout.
The Role of an Infectious Diseases Faculty Pharmacist and Pharmacy Students on an Antimicrobial Stewardship Team at a Community Non-teaching Hospital
Authors: Cusumano Jaclyn A. , Defrank Anna , Funk Olivia G. , Lerner Polina , Tanprayoon Manisa , Vasa Chirag , Mazo Dana
Published: October 2022

Background: Antimicrobial stewardship program implementation at non-teaching community hospitals differs due to staffing and resource disparities. Objective: Demonstrate that an infectious disease (ID) pharmacist faculty with advanced pharmacy practice experience (APPE) students can expand antimicrobial stewardship services at non-teaching community hospitals. Methods: A single-center, retrospective chart review was conducted comparing prospective audit and feedback antimicrobial stewardship interventions by an ID pharmacist faculty with and without APPE students between January 16, 2020 to January 16, 2021. The primary endpoints were intervention rate and the intervention acceptance rate. Secondary endpoints included: the difference in the time from antimicrobial order to intervention and length of stay, as well as comparison of acceptance rates stratified by intervention type or the antimicrobial intervened upon. Results: A total of 739 antimicrobial stewardship interventions were made with an overall acceptance rate of 55.2%. The ID pharmacist faculty with APPE students had a higher number of interventions and intervention rate per working day compared to without students (428 vs 311 and 4.46 vs 2.99, respectively). Conversely, the intervention acceptance rate was lower for the ID pharmacist faculty with APPE students vs without (48.8% vs 64%, P < .001). Both the median time from antimicrobial order to the intervention and length of stay was lower for the ID pharmacist faculty with students vs without (2.50 days [interquartile range (IQR) 1.24 - 4.01] vs 2.99 days [IQR 1.64 - 4.95], P = .003, and 9.20 days [IQR 5.57 - 14.93] vs 11.69 days [IQR 6.89 - 22.31], P < .001, respectively). The acceptance rates by intervention type and the antimicrobial intervened upon were similar between groups. Conclusion: An ID pharmacist faculty with APPE students at a non-teaching community hospital increased the number of stewardship interventions, and was associated with decreased time from antimicrobial order to intervention and length of stay.
Supporting autistic employees: Understanding and confidence in UK workplaces
Authors: Petty Stephanie , Richardson Hannah , Eccles Niamh , Tunstall Lydia
Published: October 2022

Autistic adults are underemployed. This means that workplaces are not meeting expectations of support for autistic employees and are not benefitting from a diverse workforce. This brief study investigated the current understanding in UK workplaces of adjustments and confidence with regard to supporting autistic employees. An online questionnaire was completed by 98 employees, mostly within the education sector. 15% of the respondents had a diagnosis of autism themselves. Understanding and confidence across all employees were moderate. Attending autism training in the workplace was associated with a better understanding of adjustments that could be made, but having autistic family or friends and having autistic colleagues were both associated with higher confidence in supporting autistic employees and understanding of positive workplace contributions. The findings corroborate the benefits of autism training in increasing understanding of adjustments that can be made in the workplace; however, a minority of employees had completed such training. The research provides a positive focus on personal understandings of autism which aid understanding and confidence when supporting autistic colleagues. The recommendations are to update and increase the accessibility of autism training, and notably to include the perspective of autistic employees and acknowledge workplace strengths in order to improve employment prospects within the autistic community.
Characteristics of high energy-efficient Electro-hydraulic power source driven by servo motor and variable pump
Authors: Yan Zheng
Published: October 2022

An electro-hydraulic power source is a unit that provides power for a hydraulic system, whose energy efficiency determines the whole system’s energy efficiency. The electro-hydraulic variable displacement proportional pump has the disadvantages of bad controllability, slow dynamic response in low-pressure condition, and high energy consumption in its non-working period (due to its electric motor still running at a rated speed). The electro-hydraulic variable displacement pump has some drawbacks regarding bad controllability. Aiming the above problems, a new electro-hydraulic power source based on pressure-controlled variable piston pump driven by a servo motor is developed in this paper. The pump’s output pressure can be continuously controlled without throttle losses through changing a swash-plate angle of the pump, and the output flow can be continuously controlled by changing motor speeds. A simulation model is established based on the mathematical models of pressure-controlled pump and servo motor, and the characteristics of its constant pressure control and constant flow control are discussed. A test bench is built to study its characteristics of pressure control, flow control, and energy efficiency. The results show that: (1) the proposed power source can realize the pressure control of the system, the direct open-loop control performance of the electro-hydraulic pilot valve is better than that of the speed-variable proportional-integral closed-loop control; (2) the leakage caused by load pressure change can be supplemented by speed and the control accuracy error is lower than 0.2%; (3) under the situation of pressure maintaining without flow outputs, pressure unloading and constant pressure control operating, through controlling the motor speed, the energy consumption of the power source can be reduced by almost 30% compared to a traditional power source.
Agricultural Indebtedness and Livelihood Diversification in Uttar Pradesh: A Study of the Eastern and Bundelkhand Regions
Authors: Varkey Shinu
Published: October 2022

The study aims to address the issue of indebtedness among agrarian households and the associated livelihood diversification using the cases of the Eastern and Bundelkhand regions of Uttar Pradesh. It raises the following broad questions: What is the nature and extent of the debt burden experienced by the farmer households of the study areas? How do these households diversify their livelihood strategies? And what explains the livelihood outcomes of these households? It is argued that the skewed distribution of productive resources in the study regions leads to various kinds of interlinked transactions among agrarian classes in the context of production and exchange. Such interlinkages are essentially exploitative, resulting in lower crop productivity and lower returns from cultivation. In the face of lower returns from cultivation, farmers are compelled to take recourse to borrowing. The majority of these borrowings, especially by the poorer classes, are from informal sources, exposing them to usurious extortions at the hands of money lenders, traders and rich peasants/farmers, leading to difficulties in meeting payment obligations and, finally, to indebtedness. The higher debt burden has resulted in an increased livelihood diversification by agrarian households in recent years, mostly to the informal sector. We term it forced livelihood diversification, because such diversification is not the natural outcome of a development process but is forced upon the peasantry because of the non-viability of cultivation.
The Effect of Mindfulness-based Cognitive Therapy on Anxiety and Resilience of the School Going Early Adolescents with Anxiety
Authors: Peter Anoop , Srivastava Rani , Agarwal Alka , Singh Anand Pratap
Published: October 2022

Background:

The increasing mental health problems of Indian adolescents are of great concern but child-health mental service is in a nascent stage. Anxiety is the most common psychological problem found in school-going children. The psychological intervention for this high-risk population at an early stage of adolescence can prevent mental health problems.

Aim:

The study aimed to assess the applicability and effectiveness of mindfulness-based cognitive therapy (MBCT) on resilience and anxiety of early school-going adolescents with anxiety.

Method:

This study used pre, post, and follow-up with a randomized control group design. Out of 200 samples screened by Preliminary Identification Performa and Clinical Interview Schedule (PI&CI), General Health Questionnaire-12 (GHQ-12), Spence Children’s Anxiety Scale (SCAS), and Brief Psychiatry Rating Scale (BPRS-C), 72 samples aged between 10 to 14 were included in the final study and grouped into two equal groups through a simple randomized method. Psychological intervention based on mindfulness (PIBM) group with N = 36 received 12 sessions of mindfulness-based intervention (MBCT-C) but only 33 completed up to follow-up. Only N = 32 in Treatment Waiting List (TWL) group completed three assessments who received parental counseling about anxiety. The outcome measures were Child and Adolescent Mindfulness Measure (CAMM), SCAS, Bharathiar University Resilience Scale (BURS).

Result:

The findings suggested that the PIBM group significantly improved in mindfulness and resilience, and anxiety symptoms were reduced. The effect size observed is strong and the post hoc t-test showed significant change in variables in every assessment duration. The TWL group did not have significant change. Thus MBCT-C is an applicable and effective intervention for a early school-going adolescent with anxiety.
If We Treat Them, They May Live: A Single Center’s Experience with Treating Neonates Born at 22 Weeks of Gestation
Authors: Akpan Uduak Stella , Tumin Dmitry , Moore Ryan
Published: October 2022

Objective

To describe a single center’s experience with the management of neonates born at 22 weeks of gestation.

Study Design

Retrospective review of 18 neonates born alive at 22 weeks GA to 16 mothers (cohort included 2 sets of twins) from January 2017 to December 2020, and admitted to a level IV Neonatal Intensive Care Unit. Data on antenatal management was collected from maternal charts.

Results

Nine mothers delivered due to preterm labor, 5 due to preterm pre-labor rupture of membranes with intra-amniotic infection, and 2 after antepartum hemorrhage. Fourteen mothers received antenatal counseling, 75% received antenatal steroids (25% received a full course), and 31% delivered via caesarean section in honor of parental wishes. All the neonates were actively resuscitated, with 5 surviving to discharge (28%). All survivors had at least 1 morbidity at discharge. None of the infants who underwent extensive resuscitation including chest compressions, epinephrine administration, or volume expansion survived to discharge.

Conclusions

Adequate antenatal counseling with personalized decision-making consistent with parental desires is the preferred approach at the limits of viability. Although not evident in this study, antenatal interventions such as corticosteroids may improve outcomes and should be considered for families who desire neonatal resuscitation at 22 weeks.
Open latarjet procedure versus all-arthroscopic autologous tricortical iliac crest bone grafting for anterior-inferior glenohumeral instability with glenoid bone loss
Authors: Razaeian Sam , Tegtmeier Katja , Zhang Dafang , Bartsch Stefan , Kalbe Peter , Krettek Christian , Hawi Nael
Published: October 2022

Purpose

The purpose of this study is to compare the open Latarjet procedure versus the all-arthroscopic autologous tricortical iliac crest bone grafting (AICBG) technique for recurrent anterior-inferior glenohumeral instability with glenoid bone loss.

Methods

All open Latarjet and AICBG procedures for recurrent anterior-inferior shoulder instability with glenoid bone loss performed at two institutions between September 2015 and April 2019 were retrospectively analyzed. Inclusion criteria were a traumatic etiology, a glenoid surface deficiency >13.5%, and a minimum follow-up (FU) of 18 months. Primary outcomes included the subjective shoulder value, the Western Ontario Shoulder Instability (WOSI), Rowe scores including subdomains, and the four subdomains of the Constant score (pain, activities of daily living, internal rotation, external rotation). Secondary outcomes were subjective shoulder instability, EQ-5D-3 L, pain level on the VAS, level of overall satisfaction, operative time, return-to-work rate, and return-to-sports rate.

Results

Forty-three patients were available for final analysis (Latarjet: n = 21; AICBG: n = 22) at an average FU of 34.9 months (range, 22–66 months). Both techniques provided good outcomes and improved stability. The Rowe score, Rowe-range of motion, and CS-internal rotation ( p = 0.008, p<0.001, p = 0.001) were slightly better in the AICBG group. Furthermore, the WOSI physical symptoms subdomain was significantly better ( p = 0.04) in the AICBG group, while its total score did not reach statistical significance ( p = 0.07). There was no statistically significant difference in the secondary outcomes besides operative time, which was significantly shorter in the Latarjet procedure group ( p = 0.04). Overall complication rate was similar in both groups (Latarjet: 9.5% ( n = 2), AICBG: 9.1% ( n = 2)).

Conclusion

Open Latarjet and AICBG procedures provide comparable clinical outcomes except for significantly better Rowe score, Rowe-range of motion, WOSI physical symptoms subdomain, and internal rotation capacity in the AICBG group. However, these results should be carefully interpreted in the context of known minimal clinically important differences of these scores.
Noninvasive Soft Tissue Expansion Strips and Wound Complications After Total Ankle Arthroplasty
Authors: Wallace Stephen Blake , Hamati Mary , Lendrum James Alexander , Schultz Lindsey , Metzl Joshua , Moon Daniel K. , Hunt Kenneth J.
Published: October 2022

Background:

Total ankle arthroplasty through the anterior approach (TAR-AA) is an increasingly popular treatment for ankle arthritis, but it carries a known risk for wound complications. Several products have been investigated to mitigate this risk; however, most are either costly or invasive. Noninvasive skin expansion strips (NSESs) were designed to transfer tension away from the incision and induce new skin growth at the edges of the strips. We hypothesize that postoperative application of NSESs will decrease unplanned clinic visits and wound complications after TAR-AA.

Methods:

This is a prospective cohort study of 41 patients at a single institution (3 surgeons) treated with NSESs after undergoing TAR-AA. An additional 41 consecutive historical patients treated without NSESs were retrospectively included as a control group. Patients received application of NSESs in the operating room after routine wound closure and again 2 weeks postoperatively. No other changes were made to the surgeons’ wound closure technique, immobilization, follow-up timing, or rehabilitation protocols. Primary outcomes included (1) additional clinic visit required for wound assessment or suture removal, (2) superficial wound complication, and (3) deep infection.

Results:

Baseline demographics did not differ significantly from our 41 consecutively treated historical controls. Additional clinic visits for suture removal or wound evaluation were significantly lower for patients treated with NSESs (15%, 6 of 41) compared to the control group (49%, 20 of 41) ( P = .001). There was also a significant difference in the superficial wound complication rate in the treatment group vs control group, 2% and 12%, respectively ( P = .04). There were no deep infections in either group.

Conclusion:

Noninvasive skin expansion strips placed after TAR-AA with an anterior approach have the potential to decrease wound complications and unplanned clinic visits. Further high-volume or randomized studies are needed to clarify their cost effectiveness and effect on long-term outcomes.

Level of Evidence:

Level II, prospective cohort study.
Colorectal Cancer Survival Trends in the United States From 1992 to 2018 Differ Among Persons From Five Racial and Ethnic Groups According to Stage at Diagnosis: A SEER-Based Study
Authors: Pankratz Vernon S. , Kanda Deborah , Edwardson Nicholas , English Kevin , Adsul Prajakta , Li Yiting , Parasher Gulshan , Mishra Shiraz I.
Published: October 2022

Introduction

Survival following colorectal cancer (CRC) has improved in the US since 1975, but there is limited information on stage-specific survival trends among racial and ethnic subgroups.

Objectives

The purpose of this study was to estimate and compare trends in 1- and 5-year CRC cause-specific survival in the United States by both stage and race/ethnicity.

Methods

We performed a retrospective cohort study of individuals diagnosed with CRC using the 1992-2018 Surveillance, Epidemiology and End Results (SEER) database. We estimated and compared time trends in 1- and 5-year survival for CRC stage by race/ethnicity.

Results

Data from 399 220 individuals diagnosed with CRC were available. There were significant differences in stage-specific 1-year survival trends by race and ethnicity. Differences were most notable for distant stage CRC: survival probabilities increased most consistently for non-Hispanic American Indian/Alaska Native (AIAN) and Black (NHB) persons, but their trend lines were lower than those of Hispanic, and non-Hispanic Asian/Pacific Islander (API) and White (NHW) persons, whose initially greater gains appear to be slowing. Although the data do not support significant racial/ethnic differences in 5-year CRC survival trends by stage, AIAN and NHB persons have the lowest average survival probabilities for multiple CRC stages, and no racial/ethnic group has 5-year survival probabilities above 20% for distant-stage CRC.

Conclusion

Although there has been an overall improvement in adjusted CRC-specific survival probabilities since 1992, AIAN and NHB persons continue to experience worse prognosis than those of other races/ethnicities. This highlights the importance of reinvigorating efforts to understand the causes of mortality in CRC, including those which may differ according to an individual’s race or ethnicity.
Concordance of Genomic Profiles in Matched Tissue and Plasma Samples From Chinese Patients With Lung Cancer
Authors: He Yueming , Guo Weifeng , Xu Meng , Huang Junling , Zhang Xiange , Su Huanzhang , Hong Dongxia , Liu Qun
Published: October 2022

Background:

Next-generation sequencing (NGS) has been widely used to identify targetable variants for patients with solid tumors, especially lung cancer. Circulating tumor DNA (ctDNA) has emerged as an alternative approach for tumor biopsy. However, the feasibility of ctDNA in detecting molecular variants remains debatable.

Methods:

Herein, we performed NGS on matched tissue and plasma samples from 146 Chinese patients with lung cancer. The concordance of variants between tissue and plasma samples was explored at patient and variant levels.

Results:

More than 80% of patients harbored at least one concordant variant in tissue and plasma samples. A total of 506 variants were shared between tissue and plasma samples, and 432 variants were identified in tissue only and 92 variants were identified in plasma only. The sensitivity and positive predictive value (PPV) of all variants detected in plasma were 53.9% and 84.6%, respectively. High concordance was observed in several driver genes. In details, epidermal growth factor receptor exon 19 deletion ( EGFR 19del), EGFR p.S768I, anaplastic lymphoma kinase ( ALK) fusion, rearranged during transfection ( RET) fusion, and kirsten rat sarcoma viral oncogene homolog ( KRAS) p.G12C achieved a sensitivity of 90%, 100%, 85.7%, 100%, and 85.7%, respectively. Four EGFR-altered lung adenocarcinoma patients who underwent ctDNA-based NGS at initial diagnosis benefited from first-line gefitinib/icotinib with a median progression-free survival of 379.5 days.

Conclusions:

Our work provided the clinical evidence of feasibility of ctDNA-based NGS in guiding decision-making in treatment. ctDNA-based NGA could be a reliable alternative approach for tissue biopsy in patients with lung cancer.
Infrastructuring Religion: Materiality and Meaning in Ordinary Urbanism
Authors: Burchardt Marian
Published: October 2022

This article draws on the infrastructural turn in urban studies to explore the profane materialities that enable particular forms of urban religion. Assuming that cities are configurations of spaces, actors and materialities characterized by dominant modes of belonging, hegemonic definitions of public space, and hierarchical orderings of spatial uses, infrastructures are a central element of cities’ material bases. Based on ethnographic research in Cape Town, I develop the notion of “infrastructuring religion” as a new modality of the spatialization of religion. Practices of infrastructuring draw religious life into the profane realm of ordinary urbanism in which religious meanings run up against machines of bureaucratization, divergent investments in scarce space, and criminal economies. I argue that infrastructuring is an important addition to architecture and place-making as the hitherto dominant concepts for the analysis of urban religion.
Machine learning based survival prediction in Glioma using large-scale registry data
Authors: Zhao Rachel , Zhuge Ying , Camphausen Kevin , Krauze Andra V.
Published: October 2022

Gliomas are the most common central nervous system tumors exhibiting poor clinical outcomes. The ability to estimate prognosis is crucial for both patients and providers in order to select the most appropriate treatment. Machine learning (ML) allows for sophisticated approaches to survival prediction using real world clinical parameters needed to achieve superior predictive accuracy. We employed Cox Proportional hazards (CPH) model, Support Vector Machine (SVM) model, Random Forest (RF) model in a large glioma dataset (3462 patients, diagnosed 2000–2018) to explore the most optimal approach to survival prediction. Features employed were age, sex, surgical resection status, tumor histology and tumor site, administration of radiation therapy (RT) and chemotherapy status. Concordance index (c-index) was employed to assess the accuracy of survival time prediction. All three models performed well with prediction accuracy (CI 0.767, 0.771, 0.57 for CPH, SVM, RF models respectively) with the best performance achieved when incorporating RT and chemotherapy administration status which emerged as key predictive features. Within the subset of glioblastoma patients, similar prediction accuracy was achieved. These findings should prompt stricter clinician oversight over registry data accuracy through quality assurance as we move towards meaningful predictive ability using ML approaches in glioma.
Youth Perspectives on Menthol Sales Restrictions in Minneapolis and Duluth, Minnesota
Authors: Moze Joanne M. , O’Gara Erin K. , Fritz Fogel Katie , D’Silva Joanne , Matter Chris M. , Nichols Eugene M.
Published: October 2022

Although menthol cigarettes are a starter product for youth, menthol was exempted from the 2009 Tobacco Control Act, which banned all other characterizing flavors. Minneapolis and Duluth, Minnesota, implemented menthol tobacco sales restrictions in 2018 to advance health equity for youth, African American, lesbian, gay, bisexual, trans, and queer (LGBTQ), and other communities adversely affected by menthol. This evaluation assesses the policy impact on youth access to menthol tobacco, exposure to menthol advertising, and tobacco use. A core group of youth aged 14 to 17 years (n = 30) was recruited from Minneapolis and Duluth to gather data through photo voice and peer interviews 2 months before and after policy implementation. This evaluation shares the results of focus groups with these core youth where they reflected on what they observed in the community and heard from peers. The core youth identified and categorized emergent themes using the evaluation questions. Following the focus groups, the evaluation staff used these preliminary themes and coded remaining transcripts. The core youth had mixed reactions to the impact of policies on access and use because many tobacco users in their age group obtain tobacco informally through peers, family members, and online. They observed decreases in retail advertising of menthol cigarettes, although many felt e-cigarettes and online advertising were more significant issues for their age group. Findings show a need for increased education and more comprehensive policy approaches, including addressing use of flavored e-cigarettes, online tobacco sales, and informal access, making youth access to tobacco more difficult.
Brain arteriovenous malformation flow after stereotactic radiosurgery: Role of quantitative MRA
Authors: Brunozzi Denise , McGuire Laura Stone , Turchan William Tyler , Hossa Jessica , Charbel Fady , Koshy Matthew , Alaraj Ali
Published: October 2022

Background

Stereotactic radiosurgery (SRS) is a current therapeutic option for treatment of arteriovenous malformations (AVMs) located in deep or eloquent brain regions. Obliteration usually occurs in a delayed fashion, with an expected latency of 3–5 years. Here, we assess how AVM flow correlates with volume before and after SRS treatment.

Methods

Patients with supratentorial AVM treated with SRS at our institution between 2012–2022 were retrospectively reviewed. Patients were included if Quantitative Magnetic Resonance Angiography (QMRA) study was performed at baseline and at least at the first follow-up. Correlation between AVM flow and volume before and after treatment was evaluated. AVM flow and volume were additionally assessed for obliteration using the non-parametric receiver operating characteristic (ROC) curve.

Results

Twelve patients with radiologic follow-up imaging were included. Eight patients presented AVM rupture, one of which occurred after radiosurgical treatment. Three patients underwent embolization prior SRS. Mean AVM initial volume was 3.8 cc (0.1–12.4 cc), mean initial flow 174 ml/min (11–604 ml/min), both variables showed progressive reduction at follow-up (range 3–57 months); and flow decreased with volume reduction ( p < 0.001). Area under the ROC was 0.914 for both AVM flow and volume with obliteration ( p = 0.019).

Conclusions

AVM flow significantly decreased after SRS treatment, reflecting volume reduction. Baseline AVM flow and volume both predicted obliteration. QMRA provides additional non-invasive information to monitor patients after radiosurgical treatment.
Blowing-up solutions for time-fractional equations on a bounded domain
Authors: Boutiara Abdellatif , Kaabar Mohammed KA , Benbachir Maamar , Samei Mohammad Esmael , Yue Xiao-Guang
Published: October 2022

This paper proposes initial-boundary value problems for time-fractional analogs of Kuramoto-Sivashinsky, Korpusov-Pletner-Sveshnikov, Cahn-Allen, and Hoff equations due to a bounded domain. Adequate conditions for the blowing-up of solutions in limited time of previously mentioned conditions are displayed. The Pohozhaev nonlinear capacity strategy is considered. Illustrative examples are given for each of the investigated equations.

(2010) Mathematics Subject Classifications: 34A08; 34B25; 34B15.
Disseminated tuberculosis in a lung transplant recipient presenting as tenosynovitis, subcutaneous nodules, and liver abscesses
Authors: Vargas Barahona Lilian , Henao-Cordero José , Smith Joshua , Gray Alice , Marshall Carrie B. , Scherger Sias , Bajrovic Valida , Koullias Yiannis
Published: October 2022

Tuberculosis is of particular concern in lung transplant recipients. We present the case of a patient who received a double lung transplant from a deceased donor from Mexico and developed disseminated tuberculosis 60 days post-transplant manifested as tenosynovitis, liver abscesses, and subcutaneous nodules with no definitive lung allograft involvement. The recipient did not have evidence of tuberculosis on explanted lungs, had a negative interferon gamma release assay pre-transplant, and did not have risk factors for this infection. Mycobacterium tuberculosis should remain in the differential diagnosis of early post-transplant infections with atypical presentations, evidence of dissemination, or lack of improvement with appropriate antimicrobial coverage, even in the absence of typical lung findings.
The role of mobile health technologies in promoting COVID-19 prevention: A narrative review of intervention effectiveness and adoption
Authors: Katusiime Jane , Tumuhimbise Wilson , Rwambuka Mugyenyi Godfrey , Kobutungi Phionah , Mugaba Aaron , Zender Raphael , Pinkwart Niels , Musiimenta Angella
Published: October 2022

Background

Researchers have found innovative ways of using mobile health (mHealth) technologies to prevent the spread of coronavirus disease 2019 (COVID-19). However, fewer studies have been done to determine their adoption and effectiveness.

Objective

This review summarises the published evidence on the effect of mHealth technologies on the adoption of COVID-19 preventive measures, prevention knowledge acquisition and risk perception as well as technology adoption features for COVID-19 prevention.

Methods

PubMed, IEEE and Google Scholar databases were searched for peer-reviewed literature from 1 January 2020 to 31 March 2022 for studies that evaluated the effect of mHealth technologies on COVID-19 preventive measures adoption, prevention knowledge acquisition and risk perception. Thirteen studies met the inclusion criteria and were included in this review. All the included studies were checked for quality using the mHealth evidence reporting and assessment (mERA) checklist.

Results

The review found out that the utilisation of mHealth interventions such as alert text messages, tracing apps and social media platforms was associated with adherence behaviour such as wearing masks, washing hands and using sanitisers, maintaining social distance and avoiding crowded places. The use of contact tracing was linked to low-risk perception as users considered themselves well informed about their status and less likely to pose transmission risks compared to non-users. Privacy and security issues, message personalisation and frequency, technical issues and trust concerns were identified as technology adoption features that influence the use of mHealth technologies for promoting COVID-19 prevention.

Conclusion

Utilisation of mHealth may be a feasible and effective way to prevent the spread of COVID-19. However, the small study samples and short study periods prevent generalisation of the findings and calls for larger, longitudinal studies that encompass diverse study settings.
Central diabetes insipidus and burn trauma
Authors: Kopel Jonathan , Moreno Tanir , Singh Simran , Van-Spronsen Nicole , Sorensen Grant , Griswold John
Published: October 2022

Diabetes insipidus (DI) is characterized by polyuria and polydipsia. In most cases, the condition results from either an inadequate release or resistance to the activity of antidiuretic hormone in the renal collecting tubules. The underlying pathophysiology may be related to destruction the destruction or degeneration of neurons from inflammatory, autoimmune diseases, vascular diseases, Langerhans cell histiocytosis, sarcoidosis, or trauma. However, a large majority of diabetes insipidus cases (50%) are considered idiopathic. An exceedingly rare cause of idiopathic central DI occurs in burn injuries, which has only been reported in eight cases. We present an extremely rare case of idiopathic DI in a 15-year-old male with 76% total body surface area (TBSA) burns with the development of idiopathic central DI. An extensive literature review was accomplished to compare this case with the small number of previously reported case reports of idiopathic DI in burn patients.

Lay Summary

Diabetes insipidus (DI) is a rare complication of burn injuries that results from the destruction of neurons involved in the secretion of antidiuretic hormone from the pituitary gland. Only eight cases of DI have been reported in the literature in association to burn injuries. The patient in this case report received immediate fluid resuscitation, burn treatment, and intensive observation after the initial burn injury. The rapid response was likely the main reason for the absence of neurological damage as reported in the CT image. Therefore, the treatment of burn injuries remains an important step for reducing neurological damage and hormonal dysregulation leading to diabetes insipidus.
Scaffolding Junior Middle School Students’ Engagement in Online Project-based Learning During the COVID-19 Pandemic: A Case Study from East China
Authors: Zhong Cheng , Lyu Keyi
Published: October 2022

During the COVID-19 pandemic, online learning has experienced increasing utilization and poses new challenges for schoolteachers to engage students. Project-based Learning (PBL) is widely acknowledged as an effective pedagogy for motivating and involving students. However, few studies have examined scaffolds that facilitate student engagement in the context of distance PBL. This mixed-method study was conducted with grade 7 teachers and students in a junior middle school in East China from March 2020 to April 2020. Qualitative analysis was employed in interviews with 2 teachers and 21 students. Quantitative analysis was used to visualize the self-reflection reports of 39 students. The findings suggest that the scaffolds of teacher direction, technology support, peer collaboration, and parental assistance play a significant role. In addition, specific scaffolding within the above categories was revealed. The results highlight the problem-oriented, methodological, and synthesized application of various scaffold(ing)s in engaging students and emphasize that scaffolding students emotionally is the core issue to support engagement for remote learning.
Predicting attitudes towards screening for neurodegenerative diseases using OCT and artificial intelligence: Findings from a literature review
Authors: Nichol Beth AB , Hurlbert Anya C , Read Jenny CA
Published: October 2022

Recent developments in artificial intelligence (AI) and machine learning raise the possibility of screening and early diagnosis for neurodegenerative diseases, using 3D scans of the retina. The eventual value of such screening will depend not only on scientific metrics such as specificity and sensitivity but, critically, also on public attitudes and uptake. Differential screening rates for various screening programmes in England indicate that multiple factors influence uptake. In this narrative literature review, some of these potential factors are explored in relation to predicting uptake of an early screening tool for neurodegenerative diseases using AI. These include: awareness of the disease, perceived risk, social influence, the use of AI, previous screening experience, socioeconomic status, health literacy, uncontrollable mortality risk, and demographic factors. The review finds the strongest and most consistent predictors to be ethnicity, social influence, the use of AI, and previous screening experience. Furthermore, it is likely that factors also interact to predict the uptake of such a tool. However, further experimental work is needed both to validate these predictions and explore interactions between the significant predictors.
New-onset nephrotic syndrome and acute kidney injury after cabozantinib
Authors: Katz-Agranov Nurit , Sawtell Rani , Heher Yael , Trivin-Avillach Claire , Gao Xin , Sise Meghan E
Published: October 2022

Introduction:

Renal adverse events related to receptor tyrosine kinase inhibitors (RTKIs) have been reported, including elevated creatinine levels, electrolyte abnormalities, elevated blood pressure, and proteinuria. Cabozantinib is a RTKI approved for patients with renal cell carcinoma (RCC), who have failed other lines of treatment. Here we report a case of nephrotic syndrome with biopsy-proven podocytopathy shortly after starting cabozantinib.

Case description:

An 80-year-old white man with stage IV metastatic papillary RCC was started on cabozantinib for progressive RCC. At baseline he had chronic kidney disease with an estimated glomerular filtration rate of 40 mL/min/1.73 m2 (serum creatinine 1.3 mg/dL) and a urine microalbumin to creatinine ratio of 5.4 mg/g creatinine. Approximately 3 weeks after starting cabozantinib the patient presented to the hospital with nausea, vomiting, fevers, and failure to thrive and was found to have acute kidney injury (creatinine peaked at 6.0 mg/dL) and nephrotic-range proteinuria, for which a kidney biopsy was performed. Biopsy demonstrated acute tubular necrosis and podocytopathy with 90% foot process effacement.

Discussion:

Cabozantinib is a recently approved RTKI, which has previously been demonstrated to cause thrombotic micro-angiopathy (TMA). Podocytopathies have been demonstrated by biopsy in cases of other RTKI induced proteinuria, but to our knowledge this is the first case which demonstrates isolated podocytopathy temporally associated with the initiation of cabozantinib.
Obstructive sleep apnoea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation
Authors: Cubillos-Zapata Carolina , Martínez-García Miguel Ángel , Díaz-García Elena , García-Tovar Sara , Campos-Rodríguez Francisco , Sánchez-de-la-Torre Manuel , Nagore Eduardo , Martorell-Calatayud Antonio , Blasco Luis Hernández , Pastor Esther , Abad-Capa Jorge , Montserrat Josep María , Cabriada-Nuño Valentín , Cano-Pumarega Irene , Corral-Peñafiel Jaime , Arias Eva , Mediano Olga , Somoza-González María , Dalmau-Arias Joan , Almendros Isaac , Farré Ramón , Gozal David , García-Río Francisco
Published: October 2022

Background

In patients with obstructive sleep apnoea (OSA), intermittent hypoxia induces overexpression of paraspeckle component (PSPC)1, a master modulator of transforming growth factor (TGF)-β signalling, which promotes cell cancer progression through epithelial–mesenchymal transition (EMT) and acquisition of cancer stem cell (CSC)-like features. However, the persistence of intermittent hypoxia-induced effects on PSPC1, and their consequences in cancer patients are not known. To this effect, circulating PSPC1 levels were compared in patients with cutaneous melanoma with or without OSA, and their relationship with tumour aggressiveness along with thein vitroeffects of soluble PSPC1 and intermittent hypoxia on melanoma cell aggressiveness mechanisms were assessed.

Methods

In 292 cutaneous melanoma patients, sleep studies and serum levels of PSPC1 and TGF-β were evaluated. The effect of PSPC1 on expression of EMT and CSC transcription factors was assessed using melanoma cell lines with patient sera under both normoxia and intermittent hypoxia conditions.

Results

PSPC1 levels were higher in patients with moderate–severe OSA compared with mild OSA or non-OSA patients. Serum levels of PSPC1 were associated with several cutaneous melanoma clinical aggressiveness indicators. Both intermittent hypoxia exposures and serum from OSA patients upregulated TGF-β expression and amplified the expression of transcription factors associated with EMT activation and acquisition of CSC characteristics.

Conclusion

In cutaneous melanoma patients, OSA severity is associated with higher PSPC1 serum levels, which jointly with intermittent hypoxia would enhance the self-reprogramming capabilities of EMT and CSC feature acquisition of melanoma cells, promoting their intrinsic aggressiveness.
Performance of BioFire Blood Culture Identification 2 Panel (BCID2) for the detection of bloodstream pathogens and their associated resistance markers: a systematic review and meta-analysis of diagnostic test accuracy studies
Authors: Peri Anna Maria , Ling Weiping , Furuya-Kanamori Luis , Harris Patrick N. A. , Paterson David L.
Published: October 2022

Background

Early identification of bloodstream pathogens and their associated antimicrobial resistance may shorten time to optimal therapy in patients with sepsis. The BioFire Blood Culture Identification 2 Panel (BCID2) is a novel multiplex PCR detecting 43 targets directly from positive blood cultures, reducing turnaround times.

Methods

We have performed a systematic review and meta-analysis of diagnostic test accuracy studies to assess the BCID2 performance for pathogen identification and resistance markers detection compared to gold standard culture-based methods (including phenotypic and/or genotypic characterization).

Results

Nine studies were identified reporting data to build 2 × 2 tables for each BCID2 target, including 2005 blood cultures. The pooled specificity of the assay was excellent (> 97%) across most subgroups of targets investigated, with a slightly broader confidence interval for S. epidermidis (98.1%, 95% CI 93.1 to 99.5). Pooled sensitivity was also high for the major determinants of bloodstream infection, including Enterobacterales (98.2%, 95% CI 96.3 to 99.1), S. aureus (96.0%, 95% CI 90.4 to 98.4), Streptococcus spp. (96.7%, 95% CI 92.8 to 98.5), P. aeruginosa (92.7%, 95% CI 83.1 to 97.0), E. faecalis (92.3%, 95% CI 83.5 to 96.6), as well as blaCTX-M (94.9, 95% CI 85.7 to 98.3), carbapenemases (94.9%, 95% CI 83.4 to 98.6) and mecA/C & MREJ (93.9%, 95% CI 83.0 to 98.0). Sensitivity for less common targets was slightly lower, possibly due to their under-representation in the included studies.

Conclusions

BCID2 showed good performance for detecting major determinants of bloodstream infection and could support early antimicrobial treatment, especially for ESBL or carbapenemase-producing Gram-negative bacilli and methicillin-resistant S. aureus.