bluuebunny/crossref_metadata_2025 huggingface dataset:
Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study
Authors: Kashima Saori , Inoue Kazuo , Matsumoto Masatoshi
Published: July 2021

ORIC ID: 0000-0002-3401-8191. It is unknown whether the interrelationship between diabetes and muscle loss is affected by ageing. Therefore, the serum creatinine levels, an indicator of muscle mass, were compared between older people with diabetes and those without diabetes, using a cross-sectional dataset from the Yuport Medical Checkup Center Study. We classified 6133 participants without kidney dysfunction into three age-groups: early-elderly (65–69 years), middle-elderly (70–74 years), and late-elderly (≥ 75 years). The association between diabetes and the lowest creatinine level, defined as less than or equal to the 25 percentile of serum creatinine, was evaluated in each age group, by calculating the odds ratio (OR) using logistic regression. Serum creatinine levels increased with ageing in the participants, and these trends were markedly observed in the non-diabetic group. Late-elderly people with diabetes were significantly more likely to have low creatinine levels than those without diabetes, with adjusted ORs 2.50 (95% CI 1.99–4.50) in men and 2.88 (95% CI 1.47–5.64) in women. Ageing modified the effect of their diabetes status towards a lower creatinine level (p for interactions between the diabetic status and age-groups were 0.01 in men and 0.05 in women, respectively). Ageing may thus accelerate the loss of muscle mass in people with diabetes.
Changes in anterior femoral articular cartilage structure in collegiate rugby athletes with and without a history of traumatic knee joint injury following a five-month competitive season
Authors: Hori Miyuki , Terada Masafumi , Suga Tadashi , Isaka Tadao
Published: July 2021

This study aimed to examine anterior femoral cartilage morphology before (pre-season) and after (post-season) a 5-month competitive season in collegiate ruby players with and without a previous history of traumatic injury to ligamentous, meniscus, and/or cartilage structures at the knee joint. Using a prospective cohort design, 42 male collegiate rugby players with a previous history of traumatic intracapsular knee joint injury and 124 players without knee injury history were included in this study. Ultrasonography assessments of anterior femoral cartilage were performed before (pre-season) and following a 5-month athletic season (post-season). Rugby players with a history of traumatic knee joint injury had greater lateral condylar thickness (2.37 ± 0.35 mm, p = 0.03), intercondylar thickness (2.51 ± 0.47 mm, p = 0.03), and partial area (44.67 ± 7.28mm2, p = 0.02) compared to control players (lateral = 2.23 ± 0.35 mm, intercondylar = 2.32 ± 0.47 mm, partial area = 41.60 ± 7.26 mm2), regardless of pre-and post-season assessment time points. Pre-season ultrasonography assessment of lateral condylar thickness (2.34 ± 0.47 mm, p = 0.02), medial condylar thickness (2.05 ± 0.43 mm, p = 0.03), and partial area (44.10 ± 9.23 mm2, p = 0.001) were significantly greater than the post-season ultrasonography assessment time point (lateral = 2.26 ± 0.43 mm, medial = 1.98 ± 0.43 mm, partial area = 42.17 ± 8.82 mm2), regardless of group membership. Rugby players with a history of intracapsular knee joint injury displayed altered anterior femoral cartilage size via ultrasonography assessments. Regardless of a presence of injury history, collegiate rugby players showed a decrease in cartilage thickness and partial area following a 5-month competitive season.
Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients
Authors: Parisse Simona , Ferri Flaminia , Persichetti Marzia , Mischitelli Monica , Abbatecola Aurelio , Di Martino Michele , Lai Quirino , Carnevale Sara , Lucatelli Pierleone , Bezzi Mario , Rossi Massimo , De Santis Adriano , Spagnoli Alessandra , Ginanni Corradini Stefano
Published: July 2021

This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by the presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis of HCC (n = 130) or without subsequent evidence of HCC during surveillance (n = 161). Serum levels of Mg were significantly (P < 0.001) lower in patients with HCC than in those without (median [interquartile range]: 1.80 [1.62–1.90] mg/dl vs. 1.90 [1.72–2.08] mg/dl). On multivariate logistic regression, low serum Mg was associated with the presence of HCC (OR 0.047, 95% CI 0.015–0.164; P < 0.0001), independently from factors that can influence magnesaemia and HCC development. In a subset of 94 patients with HCC, a linear mixed effects model adjusted for confounders showed that serum Mg at diagnosis of HCC was lower than before diagnosis of the tumor (β = 0.117, 95% CI 0.039–0.194, P = 0.0035) and compared to after locoregional treatment of HCC (β = 0.079, 95% CI 0.010–0.149, P = 0.0259), with two thirds of patients experiencing these changes of serum Mg over time. We hypothesize that most HCCs, like other cancers, may be avid for Mg and behave like a Mg trap, disturbing the body’s Mg balance and resulting in lowering of serum Mg levels.
Relational quality and uncertainty in common pool water management: an exploratory lab experiment
Authors: Brugnach Marcela , de Waard Sander , Dubois Dimitri , Farolfi Stefano
Published: July 2021

If there is one certainty for the sustainable management of water resources is that facing uncertainty is an unavoidable matter. A concern that, in addition to the best available scientific knowledge and models, requires deep insights about the socio relational processes that underlie decision-making. Our objective here is to better understand if and how the socio relational environment in which decisions are made shapes decision-making under uncertainty in common pool water resource management. Our goal is twofold: methodological and analytical. It consists in designing experiments for carrying out uncertainty analysis to explore the influence that the relationships established among decision actors have in making decision choices under uncertainty in management processes. To this end, we developed one experimental game protocol, representing a typical water management scenario:irrigation, which we use to test two different conjectures about the combined effects of uncertainty and relationships. In doing so, we play close attention to the quality of relationships developed among players (acting as water managers), and how these relationships are structured and organized. Initial tests confirmed the importance that the relationships established among players have for coping with uncertainty in managing water resources.
Gyrotactic micro-organism flow of Maxwell nanofluid between two parallel plates
Authors: Xu Yun-Jie , Bilal Muhammad , Al-Mdallal Qasem , Khan Muhammad Altaf , Muhammad Taseer
Published: July 2021

The present study explores incompressible, steady power law nanoliquid comprising gyrotactic microorganisms flow across parallel plates with energy transfer. In which only one plate is moving concerning another at a time. Nonlinear partial differential equations have been used to model the problem. Using Liao's transformation, the framework of PDEs is simplified to a system of Ordinary Differential Equations (ODEs). The problem is numerically solved using the parametric continuation method (PCM). The obtained results are compared to the boundary value solver (bvp4c) method for validity reasons. It has been observed that both the results are in best settlement with each other. The temperature, velocity, concentration and microorganism profile trend versus several physical constraints are presented graphically and briefly discussed. The velocity profile shows positive response versus the rising values of buoyancy convection parameters. While the velocity reduces with the increasing effect of magnetic field, because magnetic impact generates Lorentz force, which reduces the fluid velocity.
Increasing medicinal and phytochemical compounds of coneflower (Echinacea purpurea L.) as affected by NO3−/NH4+ ratio and perlite particle size in hydroponics
Authors: Ahmadi Fatemeh , Samadi Abbas , Sepehr Ebrahim , Rahimi Amir , Shabala Sergey
Published: July 2021

Medicinal plants are considered as one of the most important sources of chemical compounds, so preparing a suitable culture media for medicinal plant growth is a critical factor. The present study is aimed to improve the caffeic acid derivatives and alkylamides percentages ofEchinacea purpurearoot extract in hydroponic culture media with different perlite particle size and NO3−/NH4+ratios. Perlite particle size in the growing media was varied as very coarse perlite (more than 2 mm), coarse perlite (1.5–2 mm), medium perlite (1–1.5 mm), fine perlite (0.5–1 mm), and very fine perlite (less than 0.5 mm) in different ratios to peat moss (including pure perlite, 50:50 v/v, 30:70 v/v, and pure peat moss). Two NO3−/NH4+ratios (90:10 and 70:30) were tested in each growing media. All phytochemical analyses were performed according to standard methods using high performance liquid chromatography (HPLC). It was found that theE. purpureagrown in the medium containing very fine-grade perlite with 50:50 v/v perlite to peat moss ratio had the maximum caffeic acid derivatives, including chicoric acid (17 mg g−1DW), caftaric acid (6.3 mg g−1DW), chlorogenic acid (0.93 mg g−1DW), cynarin (0.84 mg g−1DW), and echinacoside (0.73 mg g−1DW), as well as, alkylamides (54.21%). The percentages of these phytochemical compounds increased by decreasing perlite particle size and increasing of NO3−/NH4+ratio. The major alkylamide in theE. purpurearoot extract was dodeca-2E, 4E, 8Z-10 (E/Z)-tetraenoic acid isobutylamide in all treatments, ranging from 31.12 to 54.21% of total dry weight. It can be concluded that optimizing hydroponic culture media and nutrient solution has significant effects onE. purpureachemical compounds.
Automated stomata detection in oil palm with convolutional neural network
Authors: Kwong Qi Bin , Wong Yick Ching , Lee Phei Ling , Sahaini Muhammad Syafiq , Kon Yee Thung , Kulaveerasingam Harikrishna , Appleton David Ross
Published: July 2021

Stomatal density is an important trait for breeding selection of drought tolerant oil palms; however, its measurement is extremely tedious. To accelerate this process, we developed an automated system. Leaf samples from 128 palms ranging from nursery (1 years old), juvenile (2–3 years old) and mature (> 10 years old) were collected to build an oil palm specific stomata detection model. Micrographs were split into tiles, then used to train a stomata object detection convolutional neural network model through transfer learning. The detection model was then tested on leaf samples acquired from three independent oil palm populations of young seedlings (A), juveniles (B) and productive adults (C). The detection accuracy, measured in precision and recall, was 98.00% and 99.50% for set A, 99.70% and 97.65% for set B, and 99.55% and 99.62% for set C, respectively. The detection model was cross-applied to another set of adult palms using stomata images taken with a different microscope and under different conditions (D), resulting in precision and recall accuracy of 99.72% and 96.88%, respectively. This indicates that the model built generalized well, in addition has high transferability. With the completion of this detection model, stomatal density measurement can be accelerated. This in turn will accelerate the breeding selection for drought tolerance.
Targeting the RNA demethylase FTO for cancer therapy
Authors: Zhou Lin-Lin , Xu Hongjiao , Huang Yue , Yang Cai-Guang
Published: July 2021

Chemical modulation of the RNA m6A demethylase FTO for cancer therapy.
Synthesis, characterization, magnetism and theoretical analysis of hetero-metallic [Ni2Ln2] partial di-cubane assemblies
Authors: Bhanja Avik , Herchel Radovan , Moreno-Pineda Eufemio , Khara Anjan , Wernsdorfer Wolfgang , Ray Debashis
Published: July 2021

Four isostructural Ni2Ln2 complexes have been synthesized; the susceptibility study confirms the ferromagnetic interaction and CASSCF calculations were performed to validate experimental magnetometry.
Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding
Authors: Ho Thao N. T. , Lee Han Siean , Swaminathan Shilpa , Goodwin Lewis , Rai Nishant , Ushay Brianna , Lewis Richard J. , Rosengren K. Johan , Conibear Anne C.
Published: July 2021

Cone snail venoms are richly decorated with posttranslational modifications. We show that tyrosine sulfation and C-terminal amidation increase the structural stability and binding of α-conotoxins.
Designing a mechanically driven spin-crossover molecular switch via organic embedding
Authors: Bhandary Sumanta , Tomczak Jan M. , Valli Angelo
Published: July 2021

A strain-induced spin-crossover in iron porphyrin is made exploitable through robust organic embedding via graphene nano-ribbons.
Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort
Authors: Guo Yi , Huang Fang , Sun Weiguang , Zhou Yuan , Chen Chunmei , Qi Changxing , Yang Jing , Li Xiao-Nian , Luo Zengwei , Zhu Hucheng , Wang Xiaochuan , Zhang Yonghui
Published: July 2021

Ten PPAPs with unusual skeletons were isolated from H. perforatum. 6 represents the first multitargeted natural product that could activate PP2A and simultaneously inhibit BACE1, which highlights 6 as a promising lead compound in AD drug development.
Solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes: access to cyclopentenones and dihydropyranols
Authors: Zhu Haiqian , Zheng Hanliang , Zhang Junhua , Feng Jian , Kong Lichun , Zhang Fang , Xue Xiao-Song , Zhu Gangguo
Published: July 2021

A solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes is developed, providing a facile access to sulfonylated cyclopentenones and dihydropyranols under mild conditions.
Iridium coated Co nanoparticles embedded into highly porous N-doped carbon nanocubes grafted with carbon nanotubes as a catalytic cathode for high-performance Li–O2 batteries
Authors: Yin Huixiang , Li Dongdong , Chi Zhenzhen , Zhang Qian , Liu Xiaoqiang , Ding Ling , Li Shaoxiang , Liu Jie , Guo Ziyang , Wang Lei
Published: July 2021

Ir–Co/HP-NC/CNT was prepared by a seed-mediated growth and Ir-coating process, and further used as a catalytic cathode for Li–O2 batteries. This cell exhibits high discharge capacity, low overpotential and superior cycling life.
Use of electroconductive biomaterials for engineering tissues by 3D printing and 3D bioprinting
Authors: Alizadeh Parvin , Soltani Mohammad , Tutar Rumeysa , Hoque Apu Ehsanul , Maduka Chima V. , Unluturk Bige Deniz , Contag Christopher H. , Ashammakhi Nureddin
Published: July 2021

Existing methods of engineering alternatives to restore or replace damaged or lost tissues are not satisfactory due to the lack of suitable constructs that can fit precisely, function properly and integrate into host tissues. Recently, three-dimensional (3D) bioprinting approaches have been developed to enable the fabrication of pre-programmed synthetic tissue constructs that have precise geometries and controlled cellular composition and spatial distribution. New bioinks with electroconductive properties have the potential to influence cellular fates and function for directed healing of different tissue types including bone, heart and nervous tissue with the possibility of improved outcomes. In the present paper, we review the use of electroconductive biomaterials for the engineering of tissues via 3D printing and 3D bioprinting. Despite significant advances, there remain challenges to effective tissue replacement and we address these challenges and describe new approaches to advanced tissue engineering.
A photovoltaic solar system applied to rural household in Peru
Authors: Milón Guzmán Juan José , Braga Sergio Leal , Ramos Mendoza Vivianyeli Garlet , Ponce Valdivia Brian Gilmar
Published: July 2021

The present research study aims to improve the efficiency of photovoltaic systems applied to homes in isolated areas. This experimental study was carried using a prototype of a rural house, located at the Technological University of Peru - Arequipa, Peru. The photovoltaic solar system, connected to the prototype house, supplied its electric loads (TV, Blu-ray, radio, refrigerator, blender, heater, washing machine, fan, iron), which were programmed to be turned on and off using digital timers during a period of 3 months (March, April and May 2020). The measured parameters were the solar power, the consumed electrical power and the electrical power of what would be an auxiliary source of energy (electric generator, for example) in case the solar resource is unavailable. The results indicate that the photovoltaic solar system could store the unused solar energy to supply the nighttime electrical loads, ensuring, in this way, the autonomy of the energy system.
A Review – Renewable energy based micro-cogeneration and hybrid energy systems
Authors: Kallio Sonja , Siroux Monica
Published: July 2021

To reduce carbon and greenhouse gas emissions, the more efficient and environmentally friendly energy production in the building sector is required. The deployment of renewable energy based microcogeneration units in the decentralized hybrid energy systems is a part of the solution. The micro combined heat and power (micro-CHP), or co-generation, units produce simultaneously heat and electricity from a single fuel source at high efficiency and close to the consumption point. These units offer significant benefits: reduced primary energy consumption, reduced CO2 emissions, and avoidance of distribution losses due to central plant and network construction. The objective of this paper is to present a review of available renewable energy based micro-CHP systems and to focus on the biomass and solar based conversion devices. Finally, a novel hybrid renewable energy system is presented by coupling renewable energy sources, such as solar and biomass for micro-CHP.
Application of a solar photovoltaic system to artisanal fishing products freezing in Peru
Authors: Guzmán Juan José Milón , Braga Sergio Leal , del Carpio Beltrán Herbert Jesús , Díaz Coa Mario Enrique
Published: July 2021

An experimental study has been carried out to reduce the costs of freezing products from artisanal fishing in Peru using a photovoltaic solar system. The refrigeration chamber and the photovoltaic system have been equipped with electrical sensors to determine the cooling efficiency and thus calculate the savings. The results indicate that it is possible to reduce costs up to 45% using photovoltaic solar energy. The target users of this technology are artisanal fishermen in Peru. Using photovoltaic energy for freezing would allow them to add value to their products and improve their selling price. In this way, fish commercialization can be performed in better sanitary conditions and at fair prices.
Energy and exergy analysis of combined cooling and power system using variable mode adsorption chiller
Authors: Alsarayreh Ahmad A. , Al-Maaitah Ayman , Attarakih Menwer , Bart Hans-Jörg
Published: July 2021

Adsorption cooling is a promising technology to recover low-temperature waste heat from a diesel genset. In this paper, an advanced adsorption chiller working in variable mode is proposed for the combined cooling and power cycle (CCP) to recover waste heat from the water jacket in the diesel genset. The chiller works on three modes based on the ambient temperature for better heat utilization. In this study, three modes were investigated: single-stage cycle mode, short-duration, and medium-duration mass recovery modes. The results show that the energy and exergy efficiency for a single-stage cycle mode is higher at an ambient temperature lower than 35 °C . In comparison, the mass recovery mode has a higher energy and exergy efficiency at an ambient temperature higher than 35 °C. The annual energy and exergy efficiency for the CCP was investigated when the chiller works with variable modes based on the ambient temperature under DUBAI weather conditions as a case study. The results show an improvement of 14.7% and 14% of the energy and exergy efficiency, respectively, for CCP with a variable mode adsorption chiller compared to diesel genset alone. The results also show the CCP with variable mode adsorption chiller has a slight improvement on both energy and exergy efficiency compared to CCP with a single-stage adsorption chiller at the same ambient conditions.
A evaluation and selection model of dredger considering marine ecological environment and dredger performance
Authors: Qi Qiang , Qiao Feifei , Wang Wenyuan , Guo Zijian , Jiang Ying
Published: July 2021

There will be total suspended solids in port dredging, which will affect aquatic organisms and water quality. Therefore, with the Green Port becoming the core concept of port development, it is necessary to consider the impact of dredging on marine ecological environment when selecting dredgers. In this paper, the calculation method of biomass loss caused by dredging is proposed, and the biomass loss is taken as the evaluation index to establish a dredger selection model considering marine ecological environment and dredger performance. The dredger selection model uses the fuzzy synthetic evaluation method based on norm grey relational grade to evaluate and select dredgers quantitatively, avoiding the influence of subjective factors on dredger selection. Finally, the feasibility of dredger selection model is verified by a practical dredging engineering and the results indicate that the dredger selection model can serve as a scientific basis for the construction of ecological port and the protection of marine environment.
Wax inhibitor performance comparison for waxy crude oil from Fang oilfield
Authors: Maneeintr Kreangkrai , Ruengnam Tanapol , Taweeaphiradeemanee Thodsaporn , Tuntitanakij Treetasase
Published: July 2021

In petroleum chemistry, waxy oil from paraffins can cause operating problems for oil production. The chemical method is used to remove by using chemicals or additives to prevent the wax problem. In this study, the performance of wax inhibitor are evaluated by the measurement of pour-point reduction and wax deposition of crude oil from Mae Soon area, Fang oilfield. Wax deposition is determined by cold finger technique. Wax inhibitors, hexane, Poly(maleic anhydride-alt-1-octadecene) (PMAO) and monoethanolamine (MEA) are mixed in oil sample at various concentrations. From the experiment, it is presented that hexane is used to reduce pour-point temperature up to 19.55 % and to reduce wax deposit up to 92.56 %. Moreover, MEA and PMAO have less effect on pour-point reduction. However, they have high efficiency to prevent wax deposition. PMAO provide the better wax deposition performance than MEA. The amount of wax deposit is lower at the same conditions. The percentage of wax deposit is from 39.19 % to 83.02 % for MEA and from 58.54 % to 88.51 % for PMAO. Furthermore, from the results, the preferred concentration of hexane can be at 10 % and PMAO can be 7500 ppm at low temperature or 5000 ppm for higher temperature. The results of this research can be applied to the practical way for wax deposition prevention operation in Mae Soon area in Fang oilfield to reduce the wax problem in the future.
Marketing mechanisms in the activity of the regional innovation ecosystem
Authors: Lanskaya Darya , Ermolenko Vladimir , Mironova Irina , Todika Marina , Yakovlenko Anastasia
Published: July 2021

The paper examines marketing problems in the activity of the innovative ecosystem of the region, the main directions of world trends in the field of innovation. The study is aimed at adapting traditional marketing methods to the specifics of the innovation market in the context of conflicting global competition in order to achieve a stable position of innovative subjects in the market of innovations. The factors that determine the life cycle of innovative ecosystems and the reasons for the very modest results of their activities are identified. The evolution of the content of the marketing mix is considered and the future of innovation is associated with marketing transformations towards customer satisfaction and retention in the innovation market. Marketing in environmental systems has a multi-circuit and multi-layer configuration structure, focused on all the special actors of the innovation ecosystem.
Trends in the rational use of municipal solid waste
Authors: Tyaglov Sergey , Rodionova Natalia , Bugayan Susanna
Published: July 2021

Is not yet possible to create a full-fledged municipal solid waste management industry in Russia, as private investors currently do not consider this area promising for investment, even if there is a positive domestic experience. Since the механизмыfree market mechanisms in this industry have not worked, it is the state that has the main task of forming all the infrastructure necessary for MSW management, so the purpose of this article is to consider the main directions of MSW use in accordance with global trends and the possibility of using the experience of other countries that have achieved high results in this area. Today, Russia generates about 70 million tons of municipal solid waste (MSW) per year. According to the figures laid down in the national project “Ecology”, by 2024, 60% of garbage should be processed, that is, sorted, and then sent for recycling, 36% of the total volume of waste should be recycled. To do this, it is necessary to additionally build capacities capable of sorting 37.1 million tons of MSW. At the same time, enterprises operating in this segment, have a shortage of financial resources - half of the approximately two hundred operators in the country have cash gaps, accounts payable and receivables are growing, and operations are becoming unprofitable. In these circumstances, it is very important to consider the mechanisms that can increase the attractiveness of the industry for business and ensure its profitability.
Analysis of Methodical Approaches to the Innovation Efficiency Assessment
Authors: Slobodnyak Ilya , Sosedova Elena
Published: July 2021

The article analyzes and evaluates the known methods for assessing the efficiency of innovation. Analysis methods are considered in three groups: methods based on an economic approach; methods based on a technocratic approach; complex method. The pros and cons of these methods are considered. Methodological approaches in a single enterprise may consist of one or more methods for assessing innovation. The method selection depends on the goals for the analysis. Methods for calculating the efficiency of innovations are presented, which are divided into 4 groups: simple; traditional, based on indicators of cash flow; methods based on the indicator of net profit and comparative analytical methods. Formulas for calculations are given. The presented methods of analyzing innovations may be applied at a specific enterprise in aggregate, depending on the tasks set by stakeholders, to select the most profitable innovations.
On the Issue of a Conceptual Model of Legal Regulation of Agricultural Activities in the Arctic zone of the Russian Federation
Authors: Voronina Natalia , Shnorr Zhanna
Published: July 2021

Pursuant to the UN Millennium Goals, approved in 2000, hunger should be eradicated in the 21st century, while addressing environmental problems that have accumulated over the past hundred years. One of the global environmental problems is climate change. Areas with the most vulnerable ecological system, in particular, the Arctic, are under a special blow. The Arctic zone of the Russian Federation (hereinafter - the RF AZ) is the territory of the national interests of our country. These are geopolitical, military, environmental, demographic and other interests. One of the current economic problems of the RF AZ is low food self-sufficiency. Therefore, one of the tasks is the growth of agricultural production. The situation is complicated by the fact that climatic changes negatively affect the food base of reindeer, there is a decrease in the volume of aquatic biological resources, and land resources are being depleted. The experience of foreign subarctic states shows that it is possible to use genetic technologies in agricultural activities. But at the same time, agricultural technologies should be safe for the environment. Therefore, the current task is the legislative definition of legal requirements, including environmental ones, for agricultural activities in the RF AZ. The purpose of the article is to define a conceptual model of legal regulation of agricultural activities in the RF AZ. By means of the methods of comparative analysis, legal hermeneutics and legal modeling, the content and form of the conceptual model of legal regulation of agricultural activities in the RF AZ have been formulated.
Smart City Technology: Ecological Sustainability
Authors: Nazarov Anton , Tovmasyan Natalya , Kovtun Denis
Published: July 2021

The Smart City concept includes a fairly wide range of characteristics of this new phenomenon for modern society. The main goal of creating smart cities is the comfortable living in them of people with a high level of well-being. The quality of living conditions for people in smart cities directly depends on how clean their natural environment is. The article examines the features of the development of the ecological vector of creating cities with maximum amenities for residents. Possible risks associated with negligence towards objects of animate and inanimate nature are listed, ways of high-quality environmental protection of cities of the future are outlined.
Introduction of “Green” Technologies in a Modern City
Authors: Назаров Антон , Ковтун Денис , Talu Stefan
Published: July 2021

The rate of improvement in the comfort of the modern urban environment significantly reduces the negative factors, arising from violations of the ecological balance of the environment: pollution of air, soil, water, depletion of the ozone layer. One of the most important problems of the modern world is the ecology of the urban environment. The article considers the factors, that negatively affect living and non-living natural objects of cities. Green innovative technologies are analyzed, through which people strive to restore the environment - air, water, soil. Measures are proposed to improve the efficiency of the application of green technologies.
Trends of the German biotech market
Authors: Reshetnikova Marina , Pugacheva Irina , Lukina Yulia
Published: July 2021

Over the past few years, biotechnology has become one of the most promising sectors of the economy. The biotech industry has been a vital instrument in developing and supplying COVID-19 vaccines in record time. The article discusses global trends in technology development in this area. The major players in the global biotechnology market have been identified, and the positions of Germany have been determined. The authors defined a crucial role of the biotech sector in German innovation and discuss the main trends in the growth of the German biotechnology market with a volume forecast of biotechnology output in Germany for 2020–2023.
Cruise tourism as a factor of sustainable development of the territories of the Russian Federation
Authors: Agaeva Nadezhda , Shchetilina Irina , Kovaleva Elena
Published: July 2021

At the present stage, the Russian Federation is at a fundamentally new stage of socio-economic development, a clear manifestation of which is expressed in the growth of economic recovery indicators, an increase in investment potential, a reorientation to domestic producers and domestic products. In this connection, the tourism sector can act as a serious tool for the socio-economic development of the Russian Federation. Tourism has a significant impact on ensuring sustainable socioeconomic development. Tourism, developing at a rapid pace, contributes to the development of related industries. The development of the tourism sector should proceed along the path of sustainable development of the constituent entities of the Russian Federation, and is aimed at removing infrastructural restrictions for the full use of the potential of the territories of Russia. In order to identify internal unused natural reserves, preserving the uniqueness and ensuring the environmental safety of the territories of advanced development. In this connection, it is advisable to use the cluster approach to clearly define the strategic territories for the development of the tourism sector. A “tourist cluster” is a collection of enterprises assembled into a single, logically structured system. They provide development, production, promotion of a tourist product. At the same time, one of the main guidelines for the development of the tourism sector is the provision of world quality standards.
Attraction of investments as the main factor in the development of the macroregion siberia
Authors: Repinskiy Oleg , Gubanischeva Maria , Romaneskul Natalya
Published: July 2021

The macroregion Siberia possess large reserves of natural resources, which makes it possible to create a modern high-tech infrastructure for their extraction and processing. The production of final products in this region can become a driving force for the development of the Russian economy in the medium and long term. Unlocking the potential of Siberia and the Far East requires significant investments comparable to the money spent by the USSR for the development of Western Siberia, the North, the Arctic and the construction of the BAM (the Baikal-Amur Mainline). The volume of public investment is insufficient for the dynamic development of the region, so to obtain additional investment funds stimulation of the private sector of the economy is required. Potential investors have the sufficient financial resources, but it is necessary to improve an investment climate in Russia. It will allow the country to attract the maximum amount of money. To improve the investment climate one should make significant changes in the management, legal, banking and other aspects of business activity in Russia.
Dynamics of the Variability of Heat and Moisture Supply Indicators and Irrigation Norms in the Сonditions of the Astrakhan Region
Authors: Olgarenko Gennadii , Kapustina Tatiana
Published: July 2021

During the scientific researches, scientific and methodological recommendations have been developed for determining the irrigation norms of crops for years with different water balance deficit availability, including a method for assessing and zoning a territory according to the coefficient of natural heat and moisture supply (moisture index) Mi, calculation models for rationing irrigation taking into account territorial and temporal variability, irrigation requirements for main crops, differentiated by natural and climatic zones within the Astrakhan Region. Based on statistical research and mathematical analysis of the main climatic indicators - air temperature and precipitation, trends and the degree of change in these indicators were investigated and identified according to observation data, as well as rational ecologically balanced regimes of irrigation of crops in the Astrakhan Region were calculated. According to the research results, based on the developed methodology, net irrigation requirements (mm) were calculated for the main forage and vegetable crops in years of different humidity (supply), taking into account the climatic zones identified by the moisture index (Mi) in the Astrakhan Region.
Analysis of the State and Development Prospects of the Irrigation Equipment Fleet in the Russian Federation
Authors: Olgarenko Gennadii , Turapin Sergei
Published: July 2021

The article presents the results of monitoring the availability and state of production of irrigation machinery and equipment in Russia. Based on the information and analytical studies carried out, data on the structure of the irrigation equipment fleet are presented, taking into account the availability and supplies of Russian and imported equipment. A complex of engineering, technical, organizational, and managerial measures has been developed, aimed at providing agricultural producers with domestic irrigation machinery, corresponding to the modern scientific and technical level of technology development in the world. A relevant issue is not only the conduct of experimental design and technological work on the development of a new generation of sprinkling equipment, which has the author’s priority of the Russian Federation but also a comprehensive State policy is needed, which creates opportunities for Russian machine-building enterprises to organize and develop serial production, will reduce the dependence of the melioration industry on imported equipment, which is consistent with the goals of the Food Security Doctrine and the Import Substitution Strategy in the Russian Federation. AIC.
Methodology for constructing an environmental barometer based on artificial intelligence technologies
Authors: Glinskiy Vladimir , Serga Lyudmila , Alekseev Mikhail
Published: July 2021

The presented article is aimed at solving the problem of implementing effective quality management of the regional ecosystem and preventing environmental threats. Trends in the reduction of species biological diversity and climate change are observed. Forecast and prevention of large-scale emergencies of various nature should become the basis for a new environmental and economic policy, at the center of which should be an updated system of environmental regulation. The problem arises of standardizing the quality of the environment, which requires the development of a methodology for its assessment based on a certain tool that determines the permissible or unacceptable anthropogenic load and thereby warns of the emergence of a threat. The scientific novelty of the research consists in the development of a methodology for constructing an environmental monitoring system (IAS “Environmental Barometer”), aimed at measuring negative pressure on the territorial ecosystem and based on a digital information and analytical system used by federal and regional authorities for effective management of environmental quality and sustainable development of the territory on the basis of formed strategies. The scientific novelty of the research consists in the development of a methodology for the implementation of environmental monitoring.
National and State Classical University in a Globalizing Modernity
Authors: Maltsev Konstantin , Alaverdyan Artem , Maltseva Anni
Published: July 2021

The classical “university of reason”, the idea of which is defined in German classical philosophy and German romanticism as “preparation for knowledge”, and “mission” - as “the formation of goodwill”, i.e. the education of a citizen, has lost its foundation in modernity: the essential unity of culture, the nation, the state, and the university is removed and the named “elements” of this unity in modern reality, presented in the liberal version of the economic paradigm, mean something else: the article indicates their new meaning, and as such are no longer connected. The thing that has replaced the “university of reason” in modernity has other tasks: to guarantee globalization by producing technical, i.e. directly useful and standardized knowledge, and to participate in the formation of human capital. The products produced by the university are offered on the global market as a competitively priced commodity; the name “university” is still kept as a “technical term” to denote a “bureaucratically and commercially oriented corporation”. (B. Ridings). At the same time, a unified educational space as one of the areas of the global order needs the formation of a cosmopolitan worldview - the structure, the content of educational programs, the form of organization of the modern university-corporation (as now - “multicultural reality”) are aimed at fulfilling such a definite task. The concept of “sustainable development” and its stated agenda, by defining educational goals, represents a way of ’politicizing’ (W. Beck), which aims to limit total market logic and balance necessary inequalities to ensure the unity of the global order; the article asks what this means for a university that has lost its essential identity and is embedded in a global network.
Integrating sustainability issues into English language courses at university
Authors: Gunina Nataliya , Mordovina Tatiana , Shelenkova Irina
Published: July 2021

Education for Sustainable Development is a relatively new methodology that promotes principles of sustainable living and is aimed at integrating sustainability issues into the curriculum at all cycles of formal education. This paper discusses how sustainability development concepts can be taught through English language courses at university. The range of topics that cover sustainable development issues within the framework of key dimensions, such as economy, society, environment and culture is selected in line with the guiding principles of Education for Sustainable Development. The approaches to designing a course in English for undergraduate non-linguistic students through the prism of sustainable development principles are highlighted. It is proposed to develop a syllabus with a focus on the areas that are embedded in the concept of Education for Sustainable Development. These include such topics as gender equality and human rights, sustainable lifestyles, promotion of a culture of peace and non-violence, global citizenship, and appreciation of cultural diversity. The paper summarizes the findings of the research conducted at universities in Russia and Turkey to develop a strategy for designing English language courses that incorporate sustainability issues.
Development of a Mechanism for the Management of University Research Activities Based on the Principles of Sustainable Development
Authors: Ketoeva Natalia , Kiseleva Maria , Dranitsyna Victoria
Published: July 2021

The article is devoted to the topical issues of performance evaluation and management of university research groups for its sustainable development. Scientific groups are one of the effective levers for increasing and activation of research activities in the university, as they cover all areas of its activities: performance of research and development work, building a portfolio of orders, preparation of applications for intellectual property objects, preparation of articles and reports, training of highly qualified personnel and implementation of expert activities. To develop a methodology for assessing the effectiveness of research teams, the existing methods for analyzing the management of research activities of universities in Russian and world practice were considered, where their advantages and disadvantages were identified. The university’s organizational and economic mechanism of research activities management was developed based on the above and the principles of sustainable development of higher education institutions.
Relevance factors of mathematical education for sustainable development
Authors: Melnikov Yury , Ivukina Yelena
Published: July 2021

Education system is viewed as an important constituent of sustainable development of a society. The spread of information technology reduces the need for mastering the computing apparatus of mathematics. On the other hand, firstly, the role of mathematics is not limited at least to its computing apparatus, the other components of the mathematical apparatus (for example, conceptual, methodological, etc.) and other aspects of mathematics (historical, activity, education of “intellectual honesty”, the formation of specific types of thinking, for example, geometric, ampect, linked with modelling, etc.) are also significant issues; secondly, the use of a computing apparatus is actually the final stage of other types of mathematical and “near-mathematical” activities. The article identifies three factors that ensure the relevance of mathematical education for the sustainable development: 1) the system of teaching mathematics should form the ability to use the mathematical apparatus for solving problems of business, management, engineering, social development, etc. (five components of this factor are highlighted); 2) focus on working with educational material at the level of typical strategies and methodology, not limited to typical algorithms; 3) presentation of mathematics as a multidimensional cultural phenomenon, in which scientific, technical, aesthetic, historical and economic as well as historical and social aspects are distinguished (this in many cases requires the processing of the teaching methods constituents, in particular, curricula alongside with the educational and methodological support).
Designing an Education System for Sustainable Development
Authors: Matekina Tatiana , Soroka Marina , Stolyarova Valentina
Published: July 2021

This article is aimed at theoretical comprehension of foreign and domestic experience in designing and implementing education for sustainable development and creating a technological model of advanced education in a technical university in the interests of sustainable development. Constructing a technological model that includes an integrated system of pedagogical technologies aimed at the formation of personal achievements and opportunities. Each student constructs and reconstructs their own capabilities based on reflection, which can act as a universal goal of using the models of anticipatory learning technologies, being also the result of anticipatory education. The analysis shows that the transition to sustainable development starts with forming a strategy implemented in education for sustainable development. The study considers the basics of the modern vision of sustainable development: the environmental component and education model. Moreover, the education model is considered from the perspective of the future as a forwardlooking education. The paper uses methods of analysis of philosophical, psychological, and pedagogical research and synthesis of theoretical ideas on the problem of conceptualization, design, and modeling, which allowed highlighting the main trends of scientific search in the world and domestic theory and practice of advanced education in terms of its sustainable development. The concept of sustainable development is considered from different positions of domestic and foreign researchers. Experience of education for sustainable development implementation both in Russia and other countries of the world shows that so far, sustainable development in education is represented in the environmental sense; therefore modeling of system concept of education for sustainable development and optimal ways of its implementation is actualized.
Airway Management of Critically Ill Pediatric Patients with Suspected or Proven Coronavirus Disease 2019 Infection: An Intensivist Point of View
Authors: Díaz Franco , Cruces Pablo
Published: July 2021

Advanced airway management of critically ill children is crucial for novel coronavirus disease 2019 (COVID-19) management in the pediatric intensive care unit, whether due to shock and hemodynamic collapse or acute respiratory failure. In this article, intubation is challenging due to the particularities of children's physiology and the underlying disease's pathophysiology, especially when an airborne pathogen, like COVID-19, is present. Unfortunately, published recommendations and guidelines for COVID-19 in pediatrics do not address in-depth endotracheal intubation in acutely ill children. We discussed the caveats and pitfalls of intubation in critically ill children.