bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of total flavones of Clematis filamentosa Dunn on the oxLDL-induced injury of vascular smooth muscle cells by regulating miR-455-5p
Authors: Xia Xiaolin , Wang Junlian , Liu Qifang
Published: October 2020

This experiment was conducted to investigate whether total flavones of Clematis filamentosa Dunn affect the inflammatory response and apoptosis of vascular smooth muscle cells induced by oxidized low-density lipoprotein (oxLDL) by regulating microRNA-455-5p (miR-455-5p). 50 mg/mL oxLDL was performed to stimulate the injury of vascular smooth muscle cells, and the total flavones of Clematis filamentosa Dunn were added at concentrations of 75, 150, and 300 Î¼g/mL. The expressions of inflammatory factors IL-1Î² and TNF-Î± were analyzed by ELISA, the apoptosis was evaluated by flow cytometry, the expression of Bcl-2 and Bax was determined by western blot, and the real-time fluorescence quantitative PCR (qRT-PCR) was applied to detect miR-455-5p expression. MiR-455-5p mimic was transfected into vascular smooth muscle cells and then induced injury with oxLDL; miR-455-5p inhibitor was transfected into vascular smooth muscle cells and treated with oxLDL and 300 Î¼g/mL total flavones of Clematis filamentosa Dunn. The above methods were employed to investigate the inflammatory response and apoptosis of cells. The total flavones of Clematis filamentosa Dunn significantly inhibited the expression of IL-1Î², TNF-Î±, apoptosis rate, Bax protein expression of oxLDL induced vascular smooth muscle cells, and remarkably promoted the expression of Bcl-2 protein and miR-455-5p, which all showed concentration dependence (p<0.05). Overexpression of miR-455-5p reduced IL-1Î², TNF-Î± expression, apoptosis rate, Bax protein expression, and greatly increased Bcl-2 protein expression in oxLDL injured vascular smooth muscle cells (p<0.05). After interfering with the expression of miR-455-5p, the inhibitory effect of total flavones of Clematis filamentosa Dunn on the expression of IL-1Î², TNF-Î±, apoptosis, Bax protein expression of oxLDL-induced vascular smooth muscle cells was reversed, and its promotion effect on Bcl-2 protein expression was also reversed. Total flavones of Clematis filamentosa Dunn can reduce oxLDL-induced vascular smooth muscle cell inflammation and inhibit its apoptosis. The mechanism of action is related to the up-regulation of miR-455-5p expression.
The combination therapy with esomeprazole and flupenthixol/melitracen in symptom improvement of erosive gastritis complicated with negative feelings compared with Esomeprazole alone
Authors: Hu Lidan , Shen Liandong , Li Dechuan , Huang Min , Xiao Xingpeng , Chen Shengquan
Published: October 2020

The purpose of this study was to evaluate the co-prescription efficacy of esomeprazole and flupenthixol/melitracen relative to that of solitary esomeprazole on erosive gastritis complicated with negative feelings. 140 erosive gastritis patients complicated with negative feelings enrolled in the present study. Seventy cases in the control group took esomeprazole, and 70 cases in the observation group received esomeprazole plus flupenthixol/Melitracen, both for 4 weeks. We gastroscopically checked the clinical symptoms, mucosal erosion, PGE2 and MDA levels in gastric mucosa, anxiety, depression, and recurrence before and after treatment in the groups. After treatment, the observation group had lower scores of clinical symptoms, mucosal erosions, Hamilton Depression Rating Scale (HAMD), and Hamilton Depression Rating Scale (HAMA) than the control group (p<0.05); as well, the observation group showed higher PGE2 and lower MDA levels than the control group (p<0.05); during six months of follow-up (100% follow-up rate), 16 and 34 recurrent cases occurred, respectively, in the observation and control groups (p<0.05).  Co-prescription of esomeprazole and flupenthixol/melitracen improved the clinical symptoms and mucosal erosions, relieved negative feelings and reduced the recurrence rate. The efficacy of the co-prescription is higher than that of the solitary prescription.
Long noncoding RNA H19 promotes vincristine resistance in multiple myeloma by targeting Akt
Authors: Wang Yigang , Xu Shijuan , Wang Lu , Liu Juanni , Wang Juan , Zhou Jun
Published: October 2020

Multiple myeloma is a malignant proliferation of plasma cells that results from a single clone. Manifestations include bone pain or fractures, kidney failure, susceptibility to infection, anemia, and hypercalcemia. To investigate the relationship between vincristine (VCR) resistance and Long noncoding RNA H19 (Lnc-RNA H19) in multiple myeloma (MM) this experiment was set up. For this aim, RT-PCR was used to detect the expression of lnc-RNA H19 in 60 MM patients from No.215 Hospital of Shaanxi Nuclear Industry and 50 healthy controls, and further detected the expression of related genes in myeloma cell lines and VCR myeloma resistant strains. MTT assay, flow cytometry assay, western-blotting assay and luciferase assay were used to analyze the growth, apoptosis and protein phosphorylation levels of drug-resistant RPMI 8226/VCR and RPMI 8226 cells after VCR treatment and plasmid transprinting. Results showed that the relative expression of lnc-RNA H19 was significantly increased in MM patients and drug-resistant strains RPMI 8226-VCR (****p<0.0001), while apoptosis of various MM cell lines increased after VCR treatment, while apoptosis of RPMI 8226-VCR was significantly decreased (***p<0.001). Lnc-RNA H19 overexpression plasmid pcdna3.1-h19 and Akt overexpression plasmid pcdna3.1-akt decreased apoptosis in RPMI 8226 cell lines without VCR resistance (***p<0.001), while the recombination of siRNA-h19 and siRNA-akt plasmid increased apoptosis in RPMI 8226-VCR (***p<0.001). The lnc-RNA H19/Akt pathway is closely related to the occurrence of VCR resistance in MM cells, and the down-regulation of H19 can significantly improve the sensitivity of VCR in MM.
Validation of an air/liquid interface device for TiO2 nanoparticle toxicity assessment on NR8383 cells: preliminary results
Authors: Leroux Mélanie M , Doumandji Zahra , Chezeau Laetitia , Hocquel Romain , Ferrari Luc , Joubert Olivier , Rihn Phèdre , Rihn Bertrand H
Published: October 2020

nvestigations on adverse biological effects of nanoparticles (NP) are performed usually either in vivo on rodents or in vitro under submerged conditions where NP are in suspension into cell culture media. However, sedimentation of NP in vitro is a continuous process and to assess the exact deposited cellular dose remains difficult, as the cellular internal dose is a function of time. Moreover, the cellular responses to NP under submerged culture conditions or by exposing rodents by nose-only to NP aerosols might differ from those observed at physiological settings at the air-liquid interface (ALI). Rat alveolar NR8383 macrophages were exposed to aerosols at the air-liquid interface. We studied TiO2 NM105, a mixture of anatase and rutile. NR8383 cells were exposed to a single dose of 3.0 cm2/cm2 of TiO2 aerosol. Following RNA extraction, transcriptome allowing full coverage of the rat genome was performed, and differentially expressed genes were retrieved. Their products were analyzed for functions and interaction with String DB. Only 126 genes were differentially expressed and 98 were recognized by String DB and give us the gene expression signature of exposed rat alveolar NR8383 macrophages. Among them, 13 display relationships at a high confidence level and the ten most differentially expressed compared to unexposed cells were: Chac1, Ccl4, Zfp668, Fam129b, Nab2, Txnip, Id1, Cdc42ep3, Dusp6 and Myc, ranked from the most overexpressed to the most under-expressed. Some of them were previously described as over or under-expressed in NP exposed cell systems. We validated in our laboratory an easy-to-use device and a physiological relevant paradigm for studying the effects of cell exposure to TiO2. Ccl4 gene expression seems to be a positive marker of exposure evidenced as well as in vivo or in both in vitro conditions.
May You Live in Interesting Times. Science vs. Pseudoscience in the Era of the Internet
Authors: Szynkiewicz Mariusz
Published: October 2020

May you live in interesting times, the famous maxim quotes. Undoubtedly, at least in the historical context, periods of political, social, scientific, or economic riots – or at least commotion, ferment, crisis – have certainly earned such a title. So have the epochs which were subject to radical transformations distorting traditional relationships and institutions, existing patterns and rules. The abovementioned “interestingness” is thus a function of a radical change, challenge and variability, somewhat a derivative of erosion, and of all that we associate it with the notion of revolution or turn, be it political, social, economic, environmental, or scientific. The paper’s core aim is to examine the nowadays constantly revised, questioned, thus, shaking demarcation between science and pseudoscience in the light of new trends such as misinformation, denialism, internetisation and memoisation of scientific discourses.
The Efficacy of Non–Vitamin K Antagonist Oral Anticoagulants in the Prevention of Left Atrial Thrombus in Patients With Atrial Fibrillation Compared With Vitamin K Antagonists: A Meta-Analysis
Authors: Liu Jun , Wu Yiping , Li Shurui , Song Lihong , Hu Chengdong
Published: October 2020

Background: There is still a paucity of data on the efficacy of non–vitamin K antagonist oral anticoagulants (NOACs) in the prevention of left atrial thrombus (LAT) formation before cardioversion or catheter ablation. To assess the efficacy of NOACs in the prevention of LAT in patients with non-valvular atrial fibrillation (NVAF) compared with vitamin K antagonists (VKAs), we conducted a meta-analysis.
Methods: We searched PubMed, Embase, and the Cochrane Library databases. For meta-analysis, dichotomous variables were analyzed by using the odds ratios (OR) computed using the Mantel Haenszel method (random models). All results were reported with 95% confidence intervals (CI).
Results: A total of 13 studies (one randomized controlled investigation and 12 observational studies) were included in the meta-analysis. There was no statistically significant difference between the NOACs and VKAs groups with respect to the odds of LAT/LAAT formations (OR 0.79; 95% CI: 0.52-1.21; P = .29; (I2 = 14%).
Conclusions: NOACs were as effective as VKAs in the prevention of LAT/LAAT formation in patients with NVAF. Though patients on NOACs therapy showed a lower incidence of LAT/LAAT formation compared with VKAs, it was not significant (P = .29).
RELEVANCE AND IMPORTANCE OF THE PEDAGOGUE`S SPORTS ANIMATION COMPETENCE
Authors: Zheleva-Terzieva Donka
Published: October 2020

In modern society, the impact of technologisation on the active physical activity of people is negative. Data on the health consequences of Hypodynamia, including on adolescents, are alarming. The article discusses the issue of Pedagogue's sports and animation competence as an opportunity to address new challenges.
Schizophrenic public administration reform in Hungary. Tension between anti-NPM systemic and pro-NPM organizational reforms
Authors: Rosta Miklós
Published: October 2020

The aim of the paper is to highlight the main characteristics of the recent Hungarian public administration reform, as well as to reveal the inconsistent nature of some of its elements and to describe the connected risks. The starting point of the article is the Magyary Zoltán public administration development programme. The reform steps are compared to the ideal type NPM approach. The Hungarian public administration reform can be characterized by strong centralization and the revitalization of Hungarian anti-liberal traditions at macro level, and by the support of the enhancement of market rules and management at micro level.
The age of symbolic economic policies?
Authors: Galbács Peter
Published: October 2020

This paper offers a few remarks on the so-called heterodoxy commentaries of recent times (e.g. Bod 2013, Csaba 2011). In accordance with the growing popularity of unusual economic policy actions, a set of “tools” is emerging that aims to exert its effects breaking with instrumental actions. Outlining a special framework of the history of mainstream economics, it will be argued that economic policy only gradually has become capable of applying this system. In our view, both the emergence of symbolic economic policies mentioned above and the rise of heterodoxy are on the same level, since certain governments can only operate through giving signals. Although it is not the time to formulate ultimate and eternal generalised statements, it may perhaps be stated that symbolic economic policies can make some room for manoeuvring available as a last resort. In other words, the possibility of a certain kind of economic policy “tools” can be derived from theoretical considerations, and this set has become highlighted recently by some constraining changes in the macroeconomic environment. Our theoretical framework will be filled sporadically with some episodes from the last few years of the economic policy of Hungary.
Teaching economics in Hungary after the crisis
Authors: Gervai Pál , Trautmann László
Published: October 2020

In the wake of the economic crisis, a question arises increasingly often: what is the role of economic culture in overcoming the crisis? Since the mid-2000s, leaders of developed countries have kept pointing out that fostering political and economic education is a driver of growth and development. Curricula are being overhauled; new modules are appearing in the study programmes of secondary schools, colleges, and university-level undergraduate courses; significant curriculum developments have been launched at the world’s leading universities in the last few years. Hungarian higher education cannot exclude itself from this process.
Investigating the effect of geographical distances and cultural proximity on the Hungarian wine trade
Authors: Balogh Jeremiás Máté
Published: October 2020

Wine is a very special product from an economic, cultural, and sociological point of view. Wine culture and wine trade play an important role in Hungary. The effect of cultural and geographical proximity on international trade has already been proven in the international trade literature. The size of bilateral trade flows between any two countries can be approximated by the gravity theory of trade. The gravity model provides empirical evidence of the relationship between the size of the economies, the distances between them, and their trade. This paper seeks to analyse the effect of cultural and geographical proximity on Hungary’s bilateral wine trade between 2000 and 2012, employing the gravity equation. The analysis is based on data from the World Bank WITS, WDI, as well as CEPII, and WTO databases. I apply OLS, Random Effects, Poisson, Pseudo-Poisson-Maximum-Likelihood and Heckman two stage estimators to calculate the gravity regression. The results show that in the case of Hungary, cultural similarity and trade liberalisation have a positive impact, while geographical distance, landlockedness, and contiguity have a negative impact on Hungarian wine exports.
Evolution of the Hungarian tax structure after 2010
Authors: Csomós Balázs , Kiss Gábor P.
Published: October 2020

The Hungarian tax system has undergone significant changes in recent years. The weight of labour taxes decreased by 3.3 percentage points, while the weight of consumption taxes increased by 3.7 percentage points between 2007 and 2012. This type of tax shift is not a country-specific one, but its rate is one of the largest in Europe. This study gives a brief overview of literature, followed by a presentation of the Hungarian tax structure in an international comparison, and a summary of the main changes of the tax system and relating measures, which entered into force after 2010. Then, in addition to the tax centralization indicators published by the Eurostat, an adjusted tax centralization indicator for the EU states is presented, which eliminates the tax component of public spending and transfers, takes into account the mandatory private pension contribution and compares the adjusted tax burden to the corresponding private tax base.
Maturity in management accounting: Exploratory study in Portuguese SME
Authors: Da Silva Laureano Raul Manuel , Cardoso Vieira Machado Maria João , Da Silva Laureano Luís Miguel
Published: October 2020

The purpose of this paper is to characterize the level of maturity of management accounting in Portuguese industrial SMEs. Specifically, the study classifies firms using Kaplan’s Four-Stage model; and introduces a new model to classify them better. The research design is exploratory. The data were collected through interviews with those responsible for management accounting in 58 Portuguese industrial SMEs. The analysis used descriptive and inferential statistics and a cluster analysis was performed to classify firms according to their management accounting characteristics. The results showed that all the SMEs belong to stage 2 of Kaplan’s model and that it is possible to classify them in one of the four stages of the proposed new model. Moreover, the type of firm and the source of capital have no influence on the level of maturity, although larger firms tend to have greater maturity. The study offers evidence that there is a clear difference between management accounting knowledge and practices, which should motivate top management to focus on the continuous training of firm employees on the latest developments in management accounting methods.
The Results of 2019 Parliamentary Elections in the Perspective of 2018 Local Government Elections
Authors: Gajewski Szymon
Published: October 2020

The analysis of the results of the elections to regional parliaments of 2018 allows to take a closer look at the current political preferences of the electorate one year before the parliamentary elections. The distribution of support for political parties in individual provinces shows that Law and Justice (PiS) enjoys constant, high and stable support, which will most likely allow this party to extend mandate to rule the country for the next 4 years. The largest opposition party, the Civic Platform (PO), sees the chances of victory in uniting further opposition groups around itself. The common start with Nowoczesna under the name of the Citizens’ Coalition (KO) did not meet the expectations. However, the distribution of support in the local government elections showed that the actions consolidating the opposition are currently the only chance to fight a leveled electoral fight with Law and Justice (PiS).
Committing a Crime as a Reason to Limit the Ability to Perform Functions in Local Government Administration
Authors:   Nicolaus Copernicus University in Toruń, Bojarski Janusz , Daśko Natalia
Published: October 2020

2018 local self-government elections in Poland were special ones. Brought to light mismatching of provisions of the Electoral Code and Act on Local Self-Government Employees and attempt to use it to obtain an advantage in fight for political power caused political emotions and legal controversies. The aim of this article is presents limits imposed by criminal law on right to be elected in this type of elections and more general, role of criminal law as a tool in politics. The article presents a problem of conflict of legal regulations regarding the right to be elected and perform a public function in a local self-government unit as a problem of conflict between will of voters and attitude of politicians to creation of law and aim they try to obtain.
Nationalism and Colonialism: Oceans, Civilizations, Races
Authors: Khomyakov Maxim B.
Published: October 2020

The article is devoted to the analysis of the complex interrelations between the imaginaries of nation and colony, and, by the same token, between nationalism and colonialism. The author argues that modern nationalism has always contained colonialism as its integral part and parcel. Colonies are interpreted as “mirrors” for the nation-building; while oceans, civilizations and races are the factors which keep distance between what is considered to be national and what is to be interpreted as colonial. In their turn, movement of the population, education and modernization were important tools for bridging the gaps between nations and their colonies. Russian national, Imperial and colonial experience in this context is rather anomalous, because, according to the author, it constantly blurs the existing boundaries and mix up differences. One of the interesting results of this historical experience is current insensitivity of Russian society to such pressing issues of the today’s European and American politics as the war against symbolic representations of the racist nationalism.
Terrestrial Laser Scanner (TLS) Measurement in A Volcanic Area: Detection of Error Source and Scanned Object Intensity
Authors: Haerani Nia , Abidin Hasanuddin Z. , Surono Surono , Wijaya Dudy D.
Published: October 2020

DOI:10.17014/ijog.7.2.179-200The purpose of the study of Terrestrial Laser Scanner (TLS) application in an active volcanic crater is to detect the influence of gas emission and local atmospheric change into the accuracy of measurement.The measurement was conducted at Papandayan Volcano crater, along with the local temperature, humidity, and air pressure (thp). The measured target located near a gas emission hole gives a significant fluctuative range due to possible false return by gas particles. The refraction index was calculated using thp data. Two correction models were applied: velocity-geometry and atmospheric delay correction. The atmospheric delay correction gives a more reliable result, however their refraction index calculation does not accomodate specific volcanic gas yet. An intensity map obtained from TLS can also be used for rock segmentation. An experiment from some types of volcanic rocks shows that the intensity value is influenced by a weathering degree of rock outcrops. Rock segmentation using TLS intensity data for fresh outcrops is relatively easier, while for weathered rocks it still needs a field check for validation. The temperature of volcanic rocks also contributes to the intensity value. It is found that the intensity increases along with the temperature of rock.
The Determination of Volcanic Characteristics Based on Deuterium and Oxygen-18 Isotope Compositions: A Case Study at Dieng Plateau, Central Java
Authors: Priatna Priatna , Sulaksana Nana , Hutabarat Johanes , Haryanto Iyan
Published: October 2020

DOI:10.17014/ijog.7.2.201-213To find out volcanic characteristics, a geochemical approach can be used, one of which is through the measurement of deuterium and oxygen-18 isotopes from condensate and crater water samples. In this study, Dieng Plateau in Central Java was chosen, because it has a wide spread of fumarole fields and crater water. In addition, research in the Dieng Plateau is very useful in the management of geological-based tourism and geopark development in the future. Results of isotope analysis in Candradimuka Crater show the average number of isotope deuterium is δD – 500/00 and isotope oxygen-18 is δ18O –30/00 which produce the value of the mixing fraction of f 18O = 47.11%. This figure is the highest isotope number compared to other craters on the Dieng Plateau. The high value of the isotope-18 mixing fraction is supported by a strong plume from three vents in Candradimuka. Meanwhile, the results of crater water isotope tests obtained the highest results in Sikidang Crater with the value of the deuterium isotope is δD = – 10.300/00 and the isotope oxygen-18 is δ18O = 6.570/00 which are in the metamorphic water area from the mixing of magmatic processes with surface meteoric water. Based on the deuterium isotope approach with oxygen-18 crater water and fumarole condensate supported by subsurface temperature data, most of the Dieng Plateau has magmatic-hydrothermal characteristics, except Candradimuka Crater which belongs to the magmatic group.
Abdominal Aort Anevrizmalarında Endovasküler Stent Greft (EVAR) Deneyimlerimiz – Tek Merkez Verisi
Authors: REYHANOĞLU Hasan , ÖZCAN Kaan
Published: October 2020

ÖZET

AMAÇ

Bu çalışmada abdominal aort anevrizması tanısı ile endovasküler aort anevrizması tamiri (EVAR) uyguladığınız 32 hastanın erken ve orta dönem sonuçları değerlendirildi.

GEREÇ VE YÖNTEMLER

Ocak 2011-Eylül 2019 tarihleri arasında endovasküler aort anevrizması onarım prosedürü uygulanan toplam 32 hasta çalışmaya dahil edildi. Hastaların demografik özellikleri, perioperatif ve postoperatif sonuçları araştırıldı.

BULGULAR:

Hastalarda ortalama yaş 71.4±8.4; 28’i hasta erkek, 4 hasta kadın idi. 8 hastada (%25) postoperatif erken dönemde komplikasyon gelişti. İki hastada Tip I endoleak, 1 hastada greft trombozu gelişti. Bir hastada femoral arter trombozu gelişti ve femoral embolektomi yapıldı. İki hastada nedeni bilinmeyen ateş gelişti. Bir hasta erken dönemde solunum sıkıntısı nedeni ile entübe edildi ve iki gün yoğun bakımda izlendi. Bir hastada işlemden 4 gün sonra gastrointestinal kanama gelişti. Bir hastada işlemden 49 ay sonra akut rüptür gelişti ve açık greft interpozisyonu yapıldı. Takip süresi boyunca mortalite gözlenmedi.

SONUÇ:

Abdominal aort anevrizmalarında endovasküler aort anevrizması tamiri açık cerrahiye kıyasla düşük bir risk profiline sahip olması nedeni ile tercih edilmesi gereken bir tedavi yöntemidir. Bu hastalarda, ameliyat sonrası komplikasyonları tespit etmek ve sekonder müdahale gereksinimini belirlemek için sıkı radyolojik takip önemlidir.
Quality of life of mothers who have children with developmental disabilities
Authors: Mahmutović Jasmina , Veladžić Najda , Mačak Hadžiomerović Amra , Branković Suada , Konjo Hadžan , Omerović Đemil
Published: October 2020

Introduction: The primary source of strength and support is the child’s family. A special role in caring for a child with developmental disabilities is played by his mother. The objective of this research is to find out the assessment of the quality of life (QOL) of disabled children mothers as well as to research the relation of sociodemographic variables of the respondents, as specified in this study and estimate the quality of their life and health.Methods: The cross-sectional study was performed by the use of the descriptive-analytical method. In a targeted association of families which have children and persons with difficulties was conducted this research on a sample of 100 registered mothers. The research instrument was the standardized questionnaire for QOL, the World Health Organization QOL-BREF and the users’ records of the mothers in the association.Results: The average age of the respondents was M = 48. 01 ± 11. 68. About 62% of the respondents are married, 54% have a high school diploma, 67% are not employed, 68% of the respondents did not declare to have health problems, and among those who declared to have health problems, the most common disease was diabetes mellitus. The average number of household members was M = 3. 44 members. The number of the household members was significantly and positively related to the domain of social interaction (rs = 0. 219; p < 0. 05), the domain of the environment (rs = 0. 220; p < 0. 05) and to the general QOL (rs = 0. 227; p < 0. 05). The age of the respondents was significantly and positivelyrelated only to the environmental domain (rs = 0. 205; p < 0. 05). The respondents who drive a car showed a significantly higher level of QOL in the field of mental health (p = 0. 042) and the environment (p = 0. 005). Concerning mothers with higher incomes rate, their QOL was better in the following domains: Physical health (p = 0. 030), mental health (p = 0. 002), environment (p = 0. 000001), and general QOL (p = 0. 0002).Conclusion: The respondents with a larger number of household members, those who have the support of family members, who were without health problems, and who independently use own car for transportation, consider their QOL as being better. Therefore, a promotional – preventive program for improving the life quality of mothers of children and persons with disabilities should include accessible life in the community and the ability to recognize the unique needs of the entire family of children and persons with disabilities.
KORKU ENDEKSİ(VIX), BİTCOİN FİYATLARI VE BİST100 ENDEKSİ ARASINDAKİ NEDENSELLİK İLİŞKİSİ ÜZERİNE AMPİRİK BİR UYGULAMA
Authors: Tunçel Mert Baran , Gürsoy Samet
Published: October 2020

21. yüzyıl toplumsal alanda birçok yeniliği beraberinde getirirken hiç şüphesiz küresel piyasalar açısından da değişim kaçınılmaz olmuştur. Bu değişikliklerden biri de piyasalardaki risk algısı olmuştur. Riskin yönetilmesi her geçen gün daha da önemli hale gelmektedir. Günümüzde uluslararası piyasalarda oluşan finansal risklerin ölçülmesine olanak tanıyan birçok risk endeksi olmakla birlikte en çok takip edilenlerden birinin de VIX korku endeksidir. Uluslararası yatırım kararı alınırken bu endeks yol gösterici olmakta ve özellikle finansal piyasalardaki fonların yönetilmesinde önemli rol oynamaktadır.
Finansal piyasalarda ortaya çıkan başka bir yenilik ise kripto para piyasaları olurken, uluslararası yatırımcının ilgisi her geçen gün daha da artmakta ve hatta bu paralarla alışveriş yapılmasını özendiren kurumların sayısı da artış göstermektedir. Bu bağlamda Bitcoine olan bu ilgi bu çalışmanın da ortaya çıkmasında motivasyon kaynaklarından biri olmuştur. Bu çalışmada 06.08.2010 ile 06.01.2020 dönemleri arasında günlük Bitcoin fiyatları ile BİST100 ve VIX korku endeksi arasındaki nedensellik ilişkisi test edilmiştir. Öncelikli olarak yapısal kırılmayı dikkate alan Zivot-Andrews testi ile durağanlık sınanmış ve daha sonra Toda Yamamoto nedensellik analizi gerçekleştirilmiştir. Çalışmanın sonucunda Bitcoin fiyatlarının her iki değişken üzerinde anlamlı bir ilişki içinde olmadığı görülürken, VIX endeksinden BİST100 endeksine doğru tek yönlü bir nedensellik etkisi gerçekleştirdiği tespit edilmiştir.
SİNEMA FİLMLERİNİN TANITIMINDA BİR HALKLA İLİŞKİLER ARACI OLARAK INSTAGRAM’IN KULLANILMASI: MÜSLÜM FİLMİ ÖRNEĞİ
Authors: ALTAR YAVUZ Oya
Published: October 2020

Gelişen teknoloji ile zaman ve mekân sınırlaması olmadan internete erişim kolaylığı sosyal medyayı en fazla tercih edilen halkla ilişkiler araçlarından biri haline getirmiştir. Diğer pek çok sektörde olduğu gibi sosyal medya, sinema sektörü için de vazgeçilmez bir tanıtım süreci unsuru haline gelmiştir. Dijital dünyanın her geçen gün farklılaşan olanakları, içerik üretimindeki farklı görsel kullanımları, hedef kitleyi zaman ve mekân sınırı olmadan yakalayabilmesi sinema filmlerinin tanıtımı açısından önemli avantajlar sağlamaktadır. Görsel paylaşıma dayalı bir sosyal medya platformu olması nedeni ile Instagram paylaşımlarını incelendiği bu çalışmada, bir halkla ilişkiler aracı olarak Instagram’ın sinema filmi tanıtımında kullanım pratikleri ortaya konmaya çalışılmıştır. Bu amaçla, 2018 yılında Türkiye’de en fazla izlenen sinema filmi olan Müslüm’ün resmi Instagram hesabı üzerinden ilk paylaşımın yapıldığı 3 Ocak 2018 tarihinden 3 Mart 2019 tarihine kadar yapılan 101 paylaşım betimsel analize tabi tutulmuştur. Araştırma sonunda Türkiye’de en fazla kullanılan sosyal medya platformlarından biri olan Instagram’ın sinema filmi tanıtımında diyalogsal halkla ilişkiler aracı olarak kullanımının sunduğu olanaklar ortaya konulmaktadır.
PAZARLAMA VE POPÜLER KÜLTÜR: YÜZÜKLERİN EFENDİSİ’NİN PAZARLAMA STRATEJİLERİYLE YENİDEN ÜRETİMİ
Authors: DOĞAN Şeyhmus
Published: October 2020

Pazarlama iletişiminde marka stratejilerinin belirlenmesinde popüler kültür referanslarından faydalanılmaktadır. Bazı markalar, pazarlama amaçları doğrultusunda, hedef müşteri gruplarını bir popüler kültür referansına bağlayarak popüler kültürden yararlanmada son derece başarılı olmaktadır. Bir marka doğru fırsatı doğru zamanda belirleyebiliyorsa, popüler kültür eğilimli pazarlama çabalarının sonuçları çok büyük olabilmektedir. Ürünlere eğlenceli, özendirici ve cezbedici bir bağlam sağlamak için filmler, diziler, müzikler ya da bir ünlü, bir sanatçı, bir TV eğlence/şov programı, bir spor ödül töreni vd. pazarlama programlarına ayrıntılı bir şekilde entegre edilebilmektedir. Bu durum, sosyal medya kanallarında ya da TV’de popüler olan bir şeye bağlanmanın ötesinde, popüler kültür referanslarının en iyi uygulamalarının inşa edilmesini ve pazarlama iletişimi adına markanın ürün veya hizmetleriyle bağlantı kurmanın yaratıcı yollarını sunabilmektedir. Popüler kültür unsurları, yeniden üretime girdiklerinde de pazarlama iletişimi açısından artı değer sağlama özelliğine sahiptirler. Söz konusu üretim, popüler kültür ürünün sıfırdan üretilmesi değil, farklı metalaşma ve hatta markalaşma süreçlerine girerek yeniden pazarlanması ve tüketilmesi ile gerçekleşmektedir. Dolayısıyla söz konusu ürün farklı mecralarda yeniden pazarlanabilmektedir. Makalenin amacı popüler kültür ürünlerinin neden ve nasıl yaygın bir pazarlama başarısı elde ettiklerini ve satış performanslarının ardındaki nedenleri açıklamaktır. Bu bağlamda çalışmada; bir popüler kültür ürünü olan Yüzüklerin Efendisi roman serisinin farklı mecralarda yeniden dolaşıma sokulmasıyla nasıl bir pazarlama başarısı haline geldiğinin analizi yapılmaya çalışılmıştır. Yüzüklerin Efendisi temalı ürünlerin farklı pazarlarda nasıl yeniden üretildiğinin pazarlama stratejileri açısından değerlendirilmesi amacına yönelik; toplanan verinin özgün formuna sadık kalınarak Yüzüklerin Efendisi romanı ve filmi üzerinden betimsel ve karşılaştırmalı analiz; devamında ise bazı nedensel ve açıklayıcı sonuçlara varmayı sağlayan sistematik analiz yapılmıştır.
HEALTH COMMUNICATION ON SOCIAL MEDIA: AN ANALYSIS ON THE TWITTER USE OF THE MINISTRY OF HEALTH IN TERMS OF PUBLIC RELATIONS MODELS
Authors: BATU Mikail , ACAR ŞENTÜRK Zülfiye , TOS Onur
Published: October 2020

Considering public institutions in Turkey, it is seen that "Ministry of Health" uses communication activities effectively and organizedly via Twitter. In addition to its announcements, the Ministry of Health also creates contents about health communication in their messages. In this context, within the scope of this study, the tweets published by the Ministry of Health from the official twitter account between September 1 and October 1 in 2019 are analyzed in historical order. Qualitative data-based quantitative coding is made on tweets published by the official account of the Ministry of Health. The aim of the study is to examine how the Ministry of Health uses social media as a public institution in the terms of public relations models and to determine their communication perspective with the principles that they reflect. Within the scope of the study, how the Ministry of Health uses the twitter account in terms of public relations models, how it benefits from twitter account from the perspective of health communication, and which information it provides people with the contents including health communication are sought to be answered. As a result of the analyzes conducted in the focus of health communication based on public relations models of Grunig and Hunt, it was found that the Ministry of Health generally shared its messages unilaterally, did not interact with its followers other than a tweet, and mostly used the public information model.
HASTANE TEMALI DİZİLERDE KİŞİLERARASI İLETİŞİMİN SORUNSALLAŞTIRILMASI: HEKİMOĞLU VE MUCİZE DOKTOR ÖRNEĞİ
Authors: DÖNMEZ İbrahim Hakan , ERDEMİR GÖZE Filiz
Published: October 2020

Sağlıklı bir kişilerarası iletişim, tıbbi tedavi sürecinin en önemli unsurlarından birisidir. Bu nedenle sağlık iletişimi başlığı altında sağlık kurumları ile halk, doktor ile hasta, doktor ile hasta yakını ya da doktor ile diğer sağlık çalışanları arasındaki iletişimin öneminden yola çıkılarak gittikçe artan sayıda bilimsel çalışma yapılmaktadır. Bu çalışma hekim, hasta, hasta yakını ve meslektaşlarıyla iletişimindeki sorunları Türkiye’nin kültürel yapısı dikkate alınarak uyarlanmış iki popüler hastane dizisi üzerinden tartışmayı amaçlamaktadır. Hekimoğlu ve Mucize Doktor adıyla yayınlanan iki dizinin ortak yönü, teknik tıbbi problemleri aşacak yetenekteki anti kahramanların sosyofobik kişiler olarak sorunsallaştırılmış olmasıdır. Sağlık probleminin iletişim sorunlarıyla iç içe geçtiği bu dizilerin, sağlık iletişimini yeniden değerlendirme olanağı sağlaması açısından önemli birer malzeme olduğu değerlendirilmektedir. Bunlar dikkate alınarak, hastane temalı dizilerin, toplumdaki sağlık iletişimi bağlamında değerlendirilebilecek algıların kristalize olmuş yönlerini bünyesinde taşıyacağı varsayılmıştır. Bu kabulle her iki dizideki karakterler iletişim sürecindeki tavırları dikkate alınarak analiz edilmiş, doktor hasta ve meslektaş iletişimindeki sorunlar, belli başlıklar altında tasnif edilip nitel olarak değerlendirilmiştir
ISPARTA YEREL BASINININ YAPISAL ÖZELLİKLERİ VE SORUNLARI
Authors: KILIÇ Seyfi , AYGÜN Ali Serkan
Published: October 2020

Günümüzde iletişim teknolojilerinde yaşanan gelişmeler birçok alanı etkilediği gibi gazetecilik alanını da büyük ölçüde etkilemiştir. Özellikle habercilik pratikleri bağlamında haber üretim süreci, sosyal medya, internet gazeteciliği ve yurttaş ihbar kanalları sayesinde büyük dönüşüm yaşamıştır. Buradan hareketle bu çalışmada Isparta yerel basınının yapısal özellikleri ve sorunlarının ortaya çıkarılması amaçlanmıştır. Bu amaç doğrultusunda Isparta’da yayın yapan gazeteler, genel durum, sorunları ve haber üretim süreci bağlamında incelenmiştir. Bu çalışmada ekonomi politik yaklaşım ve bu yaklaşımın medyayı ele alış biçimi üzerinde durulmuştur. Derinlemesine görüşme ve katılımlı gözlem yöntemlerinin uygulandığı bu çalışmanın sonunda ekonomi politik yaklaşım açısından gazetelerin, kapitalist bir endüstri olarak faaliyet gösterdikleri, haber üretiminde ağırlıklı olarak sosyal medya, internet gazeteciliği ve yurttaş ihbar kanallarından yararlandıkları, bu nedenle de daha az kişi çalıştırdıkları, bunun sonucunda da kârlılıklarını artırdıkları tespit edilmiştir.
PERAKENDECİLİKTE KİŞİSEL SATIŞIN TÜKETİCİ ALGISINA ETKİSİ: KIRTASİYE SEKTÖRÜNDE BİR ARAŞTIRMA
Authors: ULUDAĞ Numan , TOSYALI Hikmet
Published: October 2020

Günlük yaşamda ihtiyaç duyulan ürün ve hizmetlerin artarak çeşitlenmesi ve bu ihtiyaçları giderme çabalarının ortaya çıkması ile birlikte varlığından söz edilen pazarlama kavramı zamanla değişen dünya ve gelişen teknolojinin etkisiyle değişime uğramıştır. Ürün odaklı yaklaşımların yerine tüketici odaklı pazarlama yaklaşımlarının benimsenmesiyle birlikte perakendecilikte ilişkisel satış, tüketici memnuniyeti ve kişisel satış gibi kavramlar ön plana çıkmaya başlamıştır. Bu doğrultuda çalışmanın amacı genellikle aracı olmadan satış yapmayı sağlayan perakendecilikte kullanılan kişisel satış tekniklerinin ve satış temsilcisinin tüketici algısı üzerindeki etkilerini ortaya koymaktır. Çalışmanın ilk bölümünde perakendecilik, perakende stratejileri ve kişisel satışa ilişkin literatür taraması yapılarak konu ile ilgili kuramsal açıklamalara yer verilmiştir. Araştırma bölümünde ise kişisel satışın ve satış temsilcisinin tüketici algısı üzerindeki etkileri incelenmiştir. Veriler kırtasiye sektöründeki perakende mağazalarından alışveriş yapan 270 tüketiciden yüz yüze anket yöntemi ile toplanmıştır. Satış temsilcisinin iletişim ve kişisel özelliklerini de içeren sosyal beceri, tüketicinin işletme ve satış temsilcisine duyduğu güven ve tavsiye faktörlerinin hem tüketici algısı ile hem de birbirleri ile pozitif yönlü zayıf ilişkilerinin olduğu sonucuna ulaşılmıştır.
RAYMOND WILLIAMS’IN MEDYA VE KÜLTÜR TEORİSİ ÜZERİNE BİR İNCELEME
Authors: ORUÇ Mehmet Sebih
Published: October 2020

İngiliz Kültürel Çalışmalar Okulu’nun temsilcilerinden Raymond Williams, özellikle kültür, edebiyat, ve teknoloji gibi konularda önemli eserler vermiştir. Williams, bir taraftan kendisinin de beslendiği Marksizm’i eleştirerek geliştirmeye çalışırken diğer taraftan teknolojik determinizm ve kültürel seçkincilik dışında alternatif, demokratik bir teknoloji ve kültür kuramı geliştirmiştir. Williams, kültürel seçkinciliğin ve kültürel popülizmin dışında alternatif bir kültür sosyolojisinin imkanlarını ararken, teknoloji konusunda McLuhan’ın formalist determinizmine ve liberal kuramcıların naif iyimserliğine karşı teknolojinin toplumsal ve tarihsel olduğunu ortaya koymaya çalışır. Bu makalede Williams’ın iletişim ve kültürel çalışmalara yaptığı katkılar incelenmekte, bu konuları nasıl değerlendirdiği dönemindeki önemli kuramcılarla diyaloğu da dahil edilerek ele alınmaktadır. Makalede, Williams’ın kültür ve teknoloji hakkındaki kuramsal yaklaşımının, işçi sınıfı yanlısı demokratik siyasal idealleriyle uyum içerisinde olup soldaki kötümserliğe karşı bir umut arayışının ürünü olduğu ve tam da bu yüzden günümüzde yeniden tartışılması gerektiği iddia edilmektedir. Makalenin amacı Williams’ın medya ve kültür kuramını ortaya koyarak Türkiye’deki medya ve kültür çalışmalarına katkı sağlamaktır.
ETİK İLE POLİTİKANIN KESİŞİMİNDE “İHTİMAM”
Authors: ÇEKEM Karun
Published: October 2020

İhtimam etiği 1980’lerde ortaya çıkışının ardından pek çok eleştiriye tabi tutulmuş ve bu eleştiriler ışığında sürekli revize edilmiştir. Bu yazıda temel olarak bu eleştirilerden iki tanesine odaklanacağım: İhtimam etiğinin otonomi kavramını dışarıda bıraktığı ölçüde tarafların istismarına zemin hazırladığına yönelik eleştiri ve cemaatçilik eleştirisi. Bu eleştirilere tatminkar bir yanıt vermenin yollarını ise şu şekilde sıralayacağım: Otonomiyi bir bireyin özelliği olarak anlamaktansa onun ilişkisel ve bağlamsal olduğunu kabul etmek, adalet temelli yaklaşım ile ihtimam temelli yaklaşımı bütünleştirmek ve ihtimamı bir duygu olarak değil, fakat bir pratik olarak kavramak. İhtimamı bu şekilde anlamak, onu yalnızca özel alana dair etik bir kavram olmaktan çıkarıp kamusal alana da genişletilebilecek politik bir kavram haline getirmenin de yolunu açacaktır.
Primera centuria de la presencia de Hideyo Noguchi en el Perú.
Authors: Cruzado Lizardo
Published: October 2020

En este año 2020 se conmemora un siglo de la presencia física de Hideyo Noguchi en el Perú. Noguchi arribó en el marco de sus investigaciones científicas acerca de la fiebre amarilla que asolaba el norte de nuestra patria. Aquella época de epidemia e incuria, de penuria y descalabro de diversos órdenes en el tejido social, fue similar a la circunstancia que ahora nos toca vivir, y por ende hoy es necesario recordar la imagen inspiradora de este médico y prohombre, no exento de complejidades ni de errores en su naturaleza humana, pero dotado de profunda convicción, espíritu de sacrificio y entrega a la humanidad doliente a través de la ciencia. La centuria de la presencia física de Hideyo Noguchi en el Perú motiva el boceto de este perfil biográfico.
Pramuka Sebagai Wadah Meningkatkan Nilai Karakter Peduli Sosial
Authors: Rahmawati Laili Ni'matul , Yunus Siti Maryam
Published: October 2020

ABSTRACTThis study aims to determine whether there is an effect of scouting education activities on increasing the value of the social care character of students at MTs Plus Al-Hadi. In this study, researchers used a regression quantitative approach. The population in this study amounted to 71 students. The data analysis technique used statistical formulas, namely simple linear regression and multiple regression. The sampling technique in this study using saturated sampling technique. The data collection technique uses a questionnaire. From the results of this study, the following conclusions can be drawn: 1) based on the results of the tcount of 2.782 and ttable of 1.66724, (tcount> ttable) the coaching pattern variable has an influence on increasing the value of social care character in MTs Plus Al-Hadi; 2) Based on the results of tcount of 5.386 and ttable of 1.66724, (tcount> ttable) the activeness of participating in scouts has an effect on increasing the value of social care character in MTs Plus Al-Hadi; 3) Fcount: 16.535 and Ftable 3.13; means Fcount> Ftable at a 5% error rate, the significance level is 0.000 <0.05 (= 5%), then scouting activities have an influence on increasing the value of social care characters in MTs Plus Al-Hadi.ABSTRAKPenelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh kegiatan pendidikan kepramukaan terhadap peningkatan nilai karakter peduli sosial siswa MTs Plus Al-Hadi. Dalam penelitian ini peneliti menggunakan pendekatan kuantitatif regresi. Populasi dalam penelitian ini berjumlah 71 siswa. Teknik analisis data menggunakan rumus statistik yaitu regresi linier sederhana dan regresi berganda. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik sampling jenuh. Teknik pengumpulan data menggunakan kuesioner. Dari hasil penelitian ini dapat ditarik kesimpulan sebagai berikut: 1) Berdasarkan hasil thitung 2,782 dan ttabel 1,66724, (thitung> ttabel) variabel pola pembinaan berpengaruh terhadap peningkatan nilai karakter peduli sosial. di MTs Plus Al-Hadi; 2) Berdasarkan hasil thitung sebesar 5,386 dan t tabel sebesar 1,66724 (thitung> ttabel) keaktifan mengikuti pramuka berpengaruh terhadap peningkatan nilai karakter peduli sosial di MTs Plus Al-Hadi; 3) Fhitung: 16.535 dan Ftabel 3.13; Berarti Fhitung> Ftabel pada taraf kesalahan 5%, taraf signifikansi 0,000 <0,05 (= 5%), maka kegiatan pramuka berpengaruh terhadap peningkatan nilai karakter peduli sosial di MTs Plus Al-Hadi.
Pengaruh Penggunaan Media Pembelajaran Berbasis Film Terhadap Hasil Belajar IPS Siswa SMP Materi Potensi dan Pemanfaatan Sumber Daya Alam
Authors: Siti Nahdiroh , Arisona Risma Dwi
Published: October 2020

ABSTRAKMedia merupakan alat bantu yang membantu dalam proses pembelajaran. Alat bantu yang mampu mewakili sesuatu yang tidak dapat disampaikan pendidik atau guru melalui kata-kata atau kalimat. Peneliti menggunakan pendekatan kauntitatif dengan metode quasi experiment, desain yang digunakan nonequeivalent control group design.. Artinya penelitian yang menguji hubungan antara variabel penggunaan media berbasis film (variabel X ) dan hasil belajar ips dalam materi potensi dan pemanfaatan sumber daya alam (variabel Y). Populasi penelitian ini adalah seluruh kelas VII SMPN 5 Ponorogo, sampel yang digunakan pada penelitian ini hanya kelas VII A sebagai kelas kontrol  dan VII B sebagai kelas eksperimen. Pengumpulan data dengan menggunakan tes dan dokumentasi, Instrumen tes berupa soal yang berjumlah 30 soal. Jenis tes yang digunakan adalah tes pre- tes dan post-test. Untuk uji hipotesis data, digunakan hasil perhitungan pada kolom t-test. Berdasarkan tabel t-test, diketahui nilai Sig. (2-tailed) yaitu 0,020. Dengan menggunakan taraf kepercayaan 95%, maka nilai Sig. 0,020 kurang dari 0,05 (0,020 < 0,05). Maka dapat disimpulkan bahwa ada pengaruh yang signifikan penggunaan media pembelajaran berbasis filem terhadap hasil belajar IPS materi potensi dan pemanfaatan sumber daya alam. ABSTRACT               Media is a tool that helps in the learning process. Assistive devices that areable to represent something that an educator or teacher cannot convey through words or sentences. Researchers used a quantitative approach with a quasi-experimental method, the design used was nonequeivalent control group design. This means that research that examines the relationship between the variable use of film-based media (variable X) and ips learning outcomes in material potential and utilization of natural resources (variable Y). The population of this research was all class VII SMPN 5 Ponorogo, the sample used in this study was only class VII A as the control class and VII B as the experimental class. Data collection using tests and documentation, test instruments in the form of questions totaling 30 questions. The types of tests used are pre-test and post-test. To test the data hypothesis, the calculation results are used in the t-test column. Based on the t-test table, it is known that the Sig. (2-tailed) is 0.020. By using a 95% confidence level, the Sig. 0.020 is less than 0.05 (0.020 <0.05). So it can be concluded that there is a significant effect of using film-based learning media on social studies learning outcomes on the potential and utilization of natural resources.