bluuebunny/crossref_metadata_2025 huggingface dataset:
Preliminary Study on Yeasts Associated with the Production of “Tostado”—a Traditional Sweet Wine from Galicia (NW Spain)
Authors: Castrillo David , Blanco Pilar
Published: March 2024

Background: Tostado is a traditional sweet wine from the Designations of Origins (DOs) of Ribeiro and Valdeorras in Galicia (NW Spain). The harvested grapes are air-dried and pressed to increase the concentrations of sugars, acids, and flavour compounds. Therefore, knowledge of the yeasts involved in fermentation under these conditions is essential to guarantee the quality and uniqueness of the valuable, distinctive, and expensive Tostado wines. Methods: Saccharomyces and non-Saccharomyces yeasts were identified using Wallerstein Laboratory (WL) Nutrient Agar and lysine plating, followed by polymerase chain reaction (PCR) amplification, enzymatic digestion, and sequencing. Saccharomyces cerevisiae isolates were further characterised at the strain level using mitochondrial DNA (mtDNA) restriction fragment length polymorphism (RFLP). Statistical analyses were also performed, including different diversity indices, Similarity Percentage (SIMPER) analysis, principal component analysis (PCA), neighbor-joining clustering, parsimony–phylogram, and network plot. In addition, the total acidity, volatile acidity, reducing sugars, and alcoholic strength by volume of the Tostado wines were analysed. Results: A wide diversity of autochthonous yeasts was found, which were predominantly species of oenological relevance, such as Lachancea thermotolerans, Starmerella bacillaris, Hanseniaspora uvarum, Debaryomyces hansenii, Torulaspora delbrueckii, Pichia spp., and Saccharomyces cerevisiae from the must and paste stages of Tostado wine. In addition, 19 different S. cerevisiae strains were identified. This high yeast diversity, which changed from the early stages of fermentation, could contribute to the distinctive characteristics observed in Tostado wine. Conclusions: Characteristic and differentiating chemical and microbiological profiles were found as early as the pre-fermentation stages, which adds value to these special wines that have rarely been studied.
Molecular Classification and Pathogenesis of Pancreatic Adenocarcinoma and Targeted Therapies: A Review
Authors: Ruff Samantha M. , Pawlik Timothy M.
Published: March 2024

Pancreatic adenocarcinoma (PDAC) is disease with a 5-year survival of only 12%. Many patients with PDAC present with late-stage disease and even early-stage disease can often be characterized by an aggressive tumor biology. Standard therapy for metastatic PDAC consists mainly of chemotherapy regimens like FOLFIRINOX, FOLFOX, or gemcitabine and nab-paclitaxel. Research has focused on sequencing PDAC tumors to understand better the mutational landscape and transcriptomics of PDAC with the goal to develop targeted therapies. Targeted therapies may potentially minimize the toxic risks of chemotherapy and provide a long-term survival benefit. We herein review the underlying molecular pathogenesis of PDAC, as well as the classification schema created from current sequencing data, and recent updates related to targeted therapy for PDAC.
Application of Three-Dimensional Printing Technology in the Perioperative Management of Cardiac Tumours: A Review and Analysis
Authors: Wang Huan , Liang Jixiang , Zhang Gen , He Dongsheng , Du Baoluo , Ren Zhipeng , Dai Ziqiang , Lee Hsin , Li Dianyuan
Published: March 2024

Background: Multimodal imaging plays a crucial role in evaluating suspected cardiac tumours. In recent years, three-dimensional (3D) printing technology has continued to advance such that image-based 3D-printed models have been incorporated into the auxiliary diagnosis and treatment of cardiac tumour diseases. The purpose of this review is to analyze the existing literature on the application of 3D printing in cardiac tumour surgery to examine the current status of the application of this technology. Methods: By searching PubMed, Cochrane, Scopus and Google Scholar, as well as other resource databases, a completed review of the available literature was performed. Effect sizes from published studies were investigated, and results are presented concerning the use of 3D surgical planning in the management of cardiac tumours. Results: According to the reviewed literature, our study comes to the point that 3D printing is a valuable technique for planning surgery for cardiac tumours. As shown in the review report, Mucinous and sarcomatous tumours are the most commonly used tumours for 3D printing, magnetic resonance imaging (MRI) and computed tomography (CT) are the most commonly used technologies for preparing 3D printing models, the main printing technology is stereolithography, and the most used 3D modeling software is Mimics. The printing time and cost required for 3D printing are affected by factors such as the size of the type, complexity, the printed material and the 3D printing technology used. The reported research shows that 3D printing can understand the anatomy of complex tumour cases, virtual surgical simulation, as well as facilitate doctor-patient communication and clinical teaching. Conclusions: These results show that the development of 3D printing technology has brought more accurate and safe perioperative treatment options for patients with cardiac tumours. Therefore, 3D printing technology is expected to become a routine clinical diagnosis and treatment tool for cardiac tumours.
Arthonia phaeobaea (Arthoniaceae, Ascomycota) new to Asia and Russia from the Sakhalin Region
Authors: Yakovchenko L. S. , Davydov E. A.
Published: March 2024

During the study of the lichen biota of Sakhalin Island, Arthonia phaeobaea was identified basing of morphological and anatomical data. This is the first record of this rare saxicolous coastal lichen in Asia and Russia; the species was previously recorded only in Central and Northern Europe (including Arctic) and North America. The species is characterized by its thin, smooth, brown-gray continuous thallus without lichen compounds, usually with numerous black pycnidia and small, black, rounded to elongated, weakly convex apothecia, dark brown epithecium K–, pale hypothecium, colorless, (2)3–4 cross-septate ascospores constricted centrally and usually with unequal cells, hyaline conidia, narrowly ellipsoid or oblong. The maritime distribution of the species has been noted. The differences from other coastal saxicolous Arthonia species in a global scale, as well as saxicolous Arthonia, known in Russia, are discussed.
The Role of Integrin Subunit Alpha 2 (ITGA2) in Pancreatic Cancer Progression
Authors: Alfardan R. K. , Alismaeel W. N.
Published: March 2024

Background: Pancreatic cancer is a relatively uncommon type of cancer, although it is often very aggressive and highly metastases to other parts of the body. Investigating a potential gene marker or gene targeted therapy can improve the patient’s early prognosis and/or treatment. Objectives: In this study, we identify Integrin Subunit Alpha 2 (ITGA2) as a potential target in inhibiting pancreatic cancer progression. Materials and Methods: Cell cycle analysis, gene expression level, and cell proliferation assay are implanted in this study as investigational methods. Two-tailed student's t test is used to compare between the studied groups. Results: Cell cycle analysis for the transformed cell lines revealed increasing in G0/G1 phase and entering the cells the cell cycle arrest (quiescence) after knocking down ITGA2 expression. On the other hand, knocking down the ITGA2 effect, the mesenchymal to epithelial transition and the migration possibility of the cell lines by inhibiting the expression of metastatic marker vimentin. Furthermore, ITGA2 can manipulate the tumor microenvironment by downregulating extracellular matrix proteins (ECM-proteins) LAMB3, and LAMC2. Conclusion: ITGA2 downregulation reduces the cell proliferation, induces the cell cycle arrest, and reduce the possibility of metastasis in pancreatic cancer.
Does Cognitive-Behavioral Treatment Affect Putative Mechanisms of Change among Individuals with Problem Gambling? A Systematic Review and Exploratory Meta-Analysis
Authors: Free Bre'Anna , Smith E. Halle , Ginley Meredith K. , Whelan James P. , Pfund Rory A
Published: March 2024

Objective: The current study meta-analyzed results from 11 randomized controlled trials (RCTs) examining the effect of cognitive behavioral treatment (CBT) for gambling-related harm on three proposed change mechanisms: 1) self-efficacy, 2) cognitions, and 3) coping. Method: Articles were systematically reviewed across seven databases and two clinical trial registries. Only RCTs that included pre-post data on outcomes of interest were included in the meta-analysis; 11 studies, representing 876 participants, were eligible for analysis. Between-group Hedge’s g effect sizes were calculated to examine the effects of CBT relative to minimal or no treatment control on gambling cognitions, coping, and self-efficacy. Results: Compared to control conditions, CBT significantly decreased inaccurate gambling-related cognitions (g = -0.50), significantly increased coping behaviors (g = 0.27), and significantly increased self-efficacy (g = 1.27) at posttreatment. Conclusions: Results of the current meta-analysis provide support for the effectiveness of CBT on theoretically driven mechanisms of behavior change among individuals experiencing gambling-related harms and further the treatment literature regarding how treatment works to promote behavior change, mitigate harm, and improve quality of life. Results are discussed in light of limitations, methodological considerations, and future directions for better understanding change processes.
Executive Summary: The Anthropocene Epoch and Crawfordian Age: proposals by the Anthropocene Working Group
Authors: Waters Colin , Turner Simon , An Zhisheng , Barnosky Anthony , Cearreta Alejandro , Cundy Andrew , Fairchild Ian , Fiałkiewicz-Kozieł Barbara , Gałuszka Agnieszka , Grinevald Jacques , Hajdas Irka , Han Yongming , Head Martin , Ivar do Sul Juliana , Jeandel Catherine , Leinfelder Reinhold , McCarthy Francine , McNeill John , Odada Eric , Oreskes Naomi , Poirier Clément , Richter Daniel , Rose Neil , Saito Yoshiki , Shotyk William , Summerhayes Colin , Syvitski Jaia , Vidas Davor , Wagreich Michael , Williams Mark , Wing Scott , Zalasiewicz Jan , Zinke Jens
Published: March 2024

This is the Executive Summary of a report produced by the membership of the Anthropocene Working Group as part of a submission to the Subcommission on Quaternary Stratigraphy to seek formalisation of the Anthropocene as an epoch of geological time. It summarises the content of two reports and their associated appendices which provide a background to: the history of usage of the term Anthropocene, when the proposed epoch started, the characterisation of the Anthropocene geological deposits and their stratigraphic value, the recognition of the Anthropocene in different sedimentary environments, the rank and duration of the Anthropocene, the proposed Global boundary Stratigraphic Section and Point and supporting Standard Auxiliary Boundary Sections.
Computational fluid dynamics comparison of two-equation turbulence models by studying hydrodynamic parameters in the distillation trays
Authors: Abbasnia Sadegh , Alireza Abbasnia Alireza
Published: March 2024

A comparison was performed between three various (laminar, standard k-e, and standard k-w) for the calculation of hydrodynamic parameters of a Nye tray. Air and water were selected as the gas and liquid phases. The liquid phase was only supposed as a complete turbulent phase and the standard k-e model was chosen for that in three simulations. On the other hand, the gas phase was simulated with the mentioned three models (laminar, standard k-e, and standard k-w). The simulations were carried out in the froth regime and the framework of Eulerian–Eulerian. Entrainment and a couple of other hydrodynamic parameters were calculated for the industrial scale Nye tray. Ultimately, the results illustrated that the selection of standard k-w for the gas phase leads to more exact results for the hydrodynamic parameters. The obtained results from the standard k-w model were closer to experimental data than the two other models.
A framework for joint music making: behavioral findings, neural processes, and computational models
Authors: Abalde Sara F. , Rigby Ali , Keller Peter E. , Novembre Giacomo
Published: March 2024

Across different epochs and societies, humans occasionally gather to jointly make music. This universal form of collective behavior is as fascinating as it is poorly understood. As the interest in joint music making (JMM) rapidly grows, we review the state-of-the-art of this emerging science, blending behavioral, neural, and computational contributions. We present a theoretical framework synthesizing cross-field research on JMM within four components. The framework is centered upon interpersonal coordination, a crucial requirement for JMM. The other components imply the influence of individuals’ (past) experience, (current) social traits, and (future) goals on real-time coordination. Our work aims to promote the development of JMM research by organizing existing work, inspiring new questions, and fostering comparability with other research communities.
The Many Reliabilities of Psychological Dynamics: An Overview of Statistical Approaches to Estimate the Internal Consistency Reliability of Intensive Longitudinal Data
Authors: Castro-Alvarez Sebastian , Bringmann Laura Francina , Back Jason , Liu Siwei
Published: March 2024

Reliability is a key concept in psychology that has been broadly studied since the introduction of Cronbach's alpha, which is a measure of the internal consistency of a test. Despite its importance, this is a topic that is relatively understudied when dealing with intensive longitudinal data. In particular, when studying the psychological dynamics of affective states, there is no warranty that intensive longitudinal measurements are reliable. Given this, empirical researchers need tools to study and report the reliability of the scales used in intensive longitudinal research. In recent years, different approaches to estimate the reliability of the scales and the items used when studying psychological dynamics have been proposed. However, the advantages and disadvantages of each of these methods are unclear, making it difficult to determine when a certain approach would be preferred over the others. Specifically, these approaches estimate reliability indices based on different statistical models, such as linear multilevel analysis, vector autoregressive models, and dynamic factor models. Furthermore, while some methods involve estimating one reliability index for the scale that applies to the whole sample, others estimate person-specific reliability indices. This wide variety of approaches can provoke some confusion for empirical researchers. In this paper, we aim to highlight the advantages and disadvantages of different methods used to estimate the reliability of intensive longitudinal data. We also showcase their application with empirical data.
Dilemma in Designing a Mathematics Curriculum: Descriptive Versus Prescriptive Approach
Authors: Joshi Ghan Shyam
Published: March 2024

Developing Nepal's mathematics curriculum is a challenging task, requiring a crucial decision between prescriptive and descriptive curriculum approaches. This study examines prescriptive and descriptive curriculum approaches, their features, and their importance in developing school-level mathematics curriculum. Conversely, the Nepalese school mathematics curriculum predominantly exhibits a perspective and vertical structure. This study conducts a comprehensive comparative analysis of prescriptive and descriptive curriculum approaches, evaluating their objectives, limitations, and applicability. Based on the available literature, the study suggests that the collaborative curriculum model may be a suitable approach. This model involves the central government in curriculum benchmark design, with state governments defining specific educational goals and actively incorporating local input, ensuring a holistic approach to shaping the school math curriculum. The collaborative model shows promise in effectively addressing contemporary challenges in math teaching and learning issues in school mathematics, ensuring inclusivity and relevance for math learners, and paving the way for a brighter future. Additionally, this study highlights the importance of prioritizing learner identity, fostering ownership of learning, and addressing the unique needs of local communities, states, and the nation. This contributes to greater equity in society and globally.
Journeying Towards Transformative Mathematics Teacher through Critical Self-Reflection
Authors: Dhungana Hem Lal
Published: March 2024

In this autoethnographic study, I have critically explored my past experiences as a student, teacher, and educational researcher. This study shows my transformation from a traditional practitioner to a critical and culturally responsive mathematics teacher. The main purpose of this study is to portray the episode of critical self-reflection on my experiences of engaging mathematical activities, aiming at improving my practices as a teacher, practitioner-researcher and an educator by exploring students' mathematical ideas constructed through de/contextual teaching. Through this autoethnographic research, I have critically reflected upon my experience and I explored the possible ways of using cultural heritage that is contextualized in mathematics class. To analyze critically the narratives, I employed three theories: living education theory, sociocultural theory and, transformative theory. I positioned myself as a ontology, is multiple subjective realities. I am guided three paradigms such as interpretivism, criticalism and postmodern research paradigms. During this study, I came to realize that culturally decontextualized mathematics education is not able to encourage teachers to implement empowering mathematics pedagogy in meaningful learning of mathematics. In addition, transformative learning plays a vital role in learning mathematics by through contextual teaching and learning in which constructivist and precarious viewpoints empower both teachers and students to observe their views and values to build knowledge through critical self-reflection.
Comparative study of Euler's method and Runge-Kutta method to solve an ordinary differential equation through a computational approach
Authors: Paudel Dharma Raj , Bhatta Mohan Raj
Published: March 2024

Euler’s and Runge-Kutta's methods are used to solve ordinary differential equations. Euler’s methods become appropriate method for solving the equations. When the steps are small, they give reasonably accurate results. However, if the steps are not so small, the Runge-Kutta method is preferred to solve the problem. This paper uses the Python program to show the results of both methods. This computational approach shows that the Runge-Kutta method is better for small steps at solving differential equations than Euler’s method.
Impact of Foreign Direct Investment on Economic Growth
Authors: Dhungel Bashu Dev , Lamichhane Pitamber
Published: March 2024

Foreign direct investment (FDI) is a force of economic growth. FDI fills the gap between demand for capital and supply of capital that rise the productive investment and economic growth within the country. This paper aims to investigate the impact of FDI on economic growth of the country. Engel-Granger cointegration test is used by employing the time series data of 1995/96—2021/22 and error correction model. Neo-classical growth model is the main basis single equation model whereas real FDI is explanatory variable and GDP is the proxy for economic growth. Cointegration results confirms FDI makes the positive impact on economic growth in short-run as well as in long-run. The error correction term (0.67) indicates the disequilibria of GDP move towards the equilibrium at the speed of 65% in successive year. Therefore, this paper concludes to raise the FDI flows within the country. The Government should make the favorable environment — control money supply, direct remittance towards productive sector—for foreign investors which leads to rise economic growth within the country.
The Link between Water Scarcity and Forced Migration: An In-depth Analysis of Chaubise Rural Municipality Ward No 3 and 4, Dhankuta District
Authors: Limbu Lila Prasad
Published: March 2024

Using inductive and deductive methodologies, this study uses a mixed-method research design to examine migration patterns in Chaubise Rural Municipality Wards No. 3 and 4, Dhankuta District. A thorough study was built using quantitative data that was gathered using structured questionnaires and qualitative information. The study reveals a noteworthy occurrence of permanent migration, primarily driven by economic development, increased work opportunities, restricted access to clean water, and conflicts between people and wildlife. Economic expansion and better job chances stand out among these elements as the main inducers of migration. Access to drinking water is still a critical issue, although it is a secondary element due to communities' historical rejection of piped drinking water services and related levies.
Public Sector Corruption in Nepal: Causes and Consequences
Authors: Ranamagar Udaya
Published: March 2024

The research paper discusses corruption in Nepal's public sector, a significant challenge in the development agenda. The main objective of this study is to find the causes and consequences of corruption in the public sector. This study used primary and secondary data to determine the causes and consequences of corruption in Nepal. The results found that the political, court, and administration sectors are the most corruption-prone zones, losing the government's credibility. The leading causes of corruption are non-compliance with existing rules and regulations, lack of political commitment, transparency, accountability, consistency, and institutional weaknesses. Corruption reduces competitiveness and increases the cost of living, becoming a significant obstacle to economic growth, social development, and political stability. The government has taken various measures to combat corruption, including establishing anti-corruption bodies and laws. However, these measures have yet to be effective in curbing corruption, and there is a need for more significant reforms. The political leader, bureaucrats, civil society, and media should take responsibility for controlling corruption in the public sector of Nepal.
Relationship between Capital and Recurrent Expenditure with GDP Growth in Nepal: An Autoregressive Distributed Lag (ARDL) Approach
Authors: Rimal Umesh Raj
Published: March 2024

This study examines the relationship between Capital and Recurrent Expenditure with GDP Growth in Nepal. Employing a multivariate autoregressive distributed lag (ARDL) approach to the data from 1974 to 2020, the empirical findings reveal a strong long-run relationship between recurrent and capital expenditure with the nominal GDP. Interestingly, the impact of recurrent expenditure is higher than that of capital expenditure on GDP in the long run. However, the analysis highlights no clear short-run relationship. The weak short-term relationship observed may be due to the leakage of multipliers and the concentration of a major portion of expenses towards the end of the year. Consequently, the study calls for reforms in the implementation of the government budget, ensuring the even distribution of expenses throughout the fiscal year. Also, the government can increase the efficacy of its spending in the short run by pursuing policies that plug in the leakages of the spending multiplier. The outcomes of this research contribute to the broader discourse on the optimal allocation and implementation process of government resources and provide valuable insights for policymakers in Nepal seeking to bolster economic growth and development.
Study on the equilibrium and kinetics of nickel (II) adsorption on cellulose from peanut shell modified with chitosan
Authors:   Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Street, Dich Vong Hau Ward, Cau Giay District, Hanoi, Vietnam, Phung Thi Lan , Nguyen Thi Kim Giang ,   Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Street, Dich Vong Hau Ward, Cau Giay District, Hanoi, Vietnam, Ho Phuong Hien ,   Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Street, Dich Vong Hau Ward, Cau Giay District, Hanoi, Vietnam, Pham Thanh Nga ,   Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Street, Dich Vong Hau Ward, Cau Giay District, Hanoi, Vietnam
Published: March 2024

In this study, cellulose was produced by activating peanut shells with 5% NaOH as an alkaline agent and bleaching with 5 wt.% H2O2. Before being modified with chitosan, the cellulose was slightly oxidized with ammonium persulfate to introduce carboxyl groups. The equilibrium and kinetics of nickel adsorption on the as-prepared material were investigated. Langmuir, Freundlich, and Temkin isotherm models were used to describe the equilibrium isotherms. The Langmuir and Temkin adsorption isotherms were better fits to the equilibrium data than the Freundlich equation. The Langmuir monolayer adsorption capacity of nickel ions on cellulose from peanut shells modified with chitosan was found to be 25.70 mg/g. The Temkin adsorption constant was calculated as 0.45 kJ/mol. Therefore, the interaction between nickel ions and the surface of the as-prepared material are assumed to be weak. Kinetic data were evaluated by pseudo-first-order and pseudo-second-order models, and rate constants were determined. Simulations demonstrated that the pseudo-second-order equation could adequately describe the adsorption of nickel ions.
Nursery rearing freshwater prawn, Macrobrachium rosenbergii, in biofloc system integrated with red seaweed, Gracilaria tenuistipitata, at different stocking densities under zero water exchange
Authors:   College of Agriculture, Bac Lieu University, 178 Vo Thi Sau Street, Ward 8, Bac Lieu City, Bac Lieu Province, Vietnam, Ly Tien Hai , Vu Le Hoang ,   College of Agriculture, Bac Lieu University, 178 Vo Thi Sau Street, Ward 8, Bac Lieu City, Bac Lieu Province, Vietnam, Khanh Ly Van ,   College of Aquaculture and Fisheries, Can Tho University, Campus II, 3/2 Street, Xuan Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam, Anh Nguyen Thi Ngoc ,   College of Aquaculture and Fisheries, Can Tho University, Campus II, 3/2 Street, Xuan Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam
Published: March 2024

This study was conducted to assess the effects of stocking densities on the water quality, survival and growth of the freshwater prawn Macrobrachium rosenbergii postlarvae (PL) cultured in a biofloc system integrated with red seaweed (Gracilaria tenuistipitata). Postlarvae prawns weighing 0.012±0.001 g were stocked at densities of 1,000, 1,500, 2,000, and 2,500 PL/m3, noted as D1, D1.5, D2, and D2.5, respectively. Each density treatment was replicated three times and randomly assigned to 12 plastic tanks of 150 l at a salinity of 10 ppt. Red seaweed was added at a rate of 1.5 kg/m3, and molasses was used as a carbon source to maintain a C:N ratio of 15:1. No water exchange occurred during the 30-day rearing period. Results indicated that water quality parameters, including TAN and NO2-, biofloc volume, total heterotrophic bacteria, and Vibrio spp. counts, increased at higher prawn densities but remained within the appropriate range for prawn performance. Growth rate in weight and survival of prawns decreased as stocking density increased, with D1 and D1.5 showing comparable and significantly higher results compared to D2 and D2.5. Prawn production increased with rising stocking density, with a significant difference among treatments (p<0.05). Furthermore, prawns in D1 and D1.5 exhibited significantly higher feed efficiency than those in D2 and D2.5. These findings suggest that nursery rearing of prawn PL at a density of 1,500 ind/m3 in a biofloc system integrated with red seaweed offers optimal growth and feed efficiency, while maintaining good water quality and conserving water resources.
Efektivitas Pengelolaan Dana Desa dalam Upaya Peningkatan Pembangunan di Desa Sifaoroasi Kecamatan Huruna Kabupaten Nias Selatan
Authors: Rezeki Yosua Kevin , Angelia Nina , Kurniaty Evi Yunita
Published: March 2024

One of the identification problems in managing village funds in the village of Sifaoroasi, Huruna district, South Nias district, which still cannot be said to be fully effective, especially in the development of the village.  This study uses qualitative methods as data analysis.  The data sources in this study were the head of the Sifaoroasi village, the head of planning affairs, village officials, the head of the hamlet and the community of the Sifaoroasi village.  Data were collected based on data collection techniques, namely observation, interviews, documentation and data triangulation.  The results show that the management of village funds in an effort to increase development in the village of Sifaoroasi, Huruna sub-district, South Nias district is still not effective, this can be seen from the perspective of village development that has not been fully realized effectively in 2020. Thus it can be seen from the theory.  used in this research is the clarity of the objectives to be achieved, the clarity of strategic achievement of objectives, the process of analysis and problem formulation, sound policies, proper planning, proper programming, the availability of facilities and infrastructure for monitoring and control systems are still not effective and are not effective.  according to what the community wants in the village.  The factors that influence the management of village funds in Sifaoroasi village, Huruna district, South Nias district are human resources, facilities and infrastructure as well as transportation tools that support the development of the village.
Peran Dinas Pendidikan Povinsi Sumatra Utara Dalam Upaya Pengembangan Sekolah Luar Biasa (Slb) Negeri Autis
Authors: Manurung Rani R Br , Nasution Irwan , Musthafa Walid
Published: March 2024

This research is motivated by the search for the number of children with special needs, so that the number of Special Schools (SLB) has also increased and has been established in almost every district / city. From the above statement, it does not make the role of the North Sumatra Province education office complete, because the problem of education in special schools (SLB) is not only related to quantity but also quality. This means that the Education Office should also have a role in the development of Special Schools both in State Special Schools (SLB) and private Special Schools (SLB), as efforts to improve SLB can also have good quality. This study aims to see the role of the North Sumatra Provincial Education Office in the Development of Autism Special Schools. The research method used in this research is a qualitative research method with a descriptive approach that describes the actual situation. The data research method in this research is using observation, documentation and interview methods and then the data is collected. From the results of this study, it can be seen that the role of the North Sumatra Provincial Education Office in the Development Effort for the Autistic State Special School (SLB) is to coordinate, supervise and strive for better service management, monitor and report the performance of school principals and teacher performance, policies, operational policies for the level of education of children with special needs and equal distribution of educatio n for children with special needs, socializing with parents or the community that children with special needs are very important to get education.
Strategi Pelayanan dalam Rangka Meningkatkan Kunjungan Wisata ke Pantai Busung (Studi Kasus Pada Kantor Dinas Pariwisata dan Kebudayaan kabupaten Simeulue)
Authors: Nauli Anggi Funga , Muda Indra , Matondang Armansyah
Published: March 2024

attraction is able to increase the community’s economy and create jobs. The Problem in this reseach is how to the service in order to increase the tourist visits of Busung Beach and the obstacles that influence it. Method used was descriptive with a qualitative approach, namely describing data from the field and then explaining it the words. The data collection technique is triangulation in three ways, namely observation, interviews, documentation. This study involvet 7 informant, namely 2 key informants, 2 main informants, 3 additional informants. There are four factors that become the basis for analyzing the Busung Beach tourism servicy strategy, namely strangth, weaknesses, opportunities and threats. From this analysis, there are obstacles that affect tourist visit, namely the lack of community participation, the number of other tours that are competitors, the lack of creativity from the community, the lack of connecktivity, the limited skilled workforce. Based on the results of the study, it can be concluded that the strategy carried out by Busung Beach tourism objecks is to involve the community to maintain the beauty of the beach so that it looks well- geoomed and does  not  affect the natural exoticism of  the beach, provide adequate supporting faciities (prayer rooms, toilets, tourist huts, beachside cafes, boats), showing the hospotality of thr coast guart to tourist visitors, providing a fairly large play area, easy accessability to the beach, which is guaranteed enough security to increase Busung Beach tourism visitors.
Analisis Kinerja Pegawai dalam Pelayanan Administrasi Pajak Kendaraan Roda Dua di Samsat Medan Utara
Authors: Taufiq Muhammad , Adam Adam , Kurniaty Evi Yunita
Published: March 2024

The purpose of studiy was to determine employee performance in improwing the quality of two-wheeled motor vehicle tax administration services at the North Medan Samsat office and to determine the inhibiting factor/constraints on employee performance in improwing the quality of two-wheeled motor vehicle tax administration services at the nort medaan samsat office. This study uses a qualitative descriptive method using analysis of performance theory according to Agus Dwiyanto (2006) namaely productivity, service quality, responsiveness, responsibility, accountability. The results of this studiy can be conclouded that the performance of employees in improwingthe quality of taq administration services specifically for two- wheeled motor vehicles at the north medan samsat office has not gone well due to various problems and obstacles faced. Inhibiting factors or obstacles faced are service ti the community is still not optimal, employee discipline is still lacking, human resources are still;ow, internet network. The outhours suggestion in this study is that the Norts Medan Samsat employees carry out health services to the maximum without discriminating between people who take care of taxes and speed up service hours.
Implementasi Program Kartu Indonesia Sehat Di Desa Lubuk Saban Kecamatan Pantai Cermin Kabupaten Serdang Bedagai
Authors: Wati Hairida , Muda Indra , Nasution Irwan
Published: March 2024

The The healthy Indonesian card is a card that has a function to provide health insurance to the underprivileged with the aim of getting free health services in order to make it easier for the underprivileged in treatment. The purpose of this study was to determine the implementation of the Healthy Indonesia Card program in Lubuk Saban Village, Pantai Cermin District, Serdang Bedagai Regency and its inhibiting factors.The theory used is communication, resources, disposition and bureaucratic structure. The research method used is descriptive qualitative method by means of observation, interviews and documentation. The results showed that the implementation of the Healthy Indonesia Card Program in Lubuk Saban Village, Pantai Cermin District, Serdang Bedagai Regency has not been effective and has not been on target. The obstacle faced in the Healthy Indonesia Card program was the incomplete data on medicines in the health centers for recipients of the Healthy Indonesia Card. This is not optimal for village officials to communicate with the community when explaining the existence of the KIS program because at the time of gathering the community to socialize only twice a month. And with these inhibiting factors still unable to utilize the potential of natural resources, this study can be concluded that the economy of the underprivileged is helped because they do not think about the costs for medical expenses because they have been registered in the KIS program which has been socialized by the village.
Gaya Kepemimpinan Kepala Desa Dalam Pelaksanaan Pemerintahan Desa Parsingguran II Kecamatan Pollung Kabupaten Humbang Hasundutan
Authors: Gaol Novita Lumban , Batubara Beby Masitho , Kurniaty Evi Yunita
Published: March 2024

Leadership Style of the Village Head in the implementation of Village Government in Parsingguran II. Especially in leadership, the village head is still lacking in socializing, communicating and often making his own decisions so that the community does not participate in the village.study aims to determine the leadership style of village heads in village government. graduate ll. This study uses a descriptive qualitative method that provides a clear description of the problems studied by using the Kartono theory of leadership style six indicators of leadership style, namely the ability to make decisions, the ability to motivate, the ability to communicate, the ability to manage emotions, be responsible, the ability to control subordinates. Data collection techniques used are observation, interviews and documentation. The results of this study indicate that the leadership style of the village head in village government is an authoritarian leadership style, this is because it focuses all decisions and policies taken from oneself. All division of duties and responsibilities is held by the authoritarian leader. While his subordinates only carry out the tasks that have been given. In an authoritarian leadership style, the leader controls all aspects of the activity. The leader gives what goals he wants to achieve, both major goals and minor goals.
Peranan Camat dalam Pencegahan dan Pengendalian Corona Virus Disease (Covid-19) di Kecamatan Gido, Kabupaten Nias
Authors: Harefa Beby Beriman Jaya , Lubis Yurial Arief , Matondang Armansyah
Published: March 2024

Corona Virus Disease (Covid-19) is an epidemic that has an infectious nature. Covid - 19 first appeared in the city of Wuhan, Hubei Province, China and has spread to 190 countries in the world including Indonesia. Officially, WHO as the world health agency named this virus as Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS_CoV-2) or Corona Virus Disease 2019 (Covid-19). The Covid-19 virus outbreak is known to have clinical symptoms in human respiration, even to the point of severity causing death. On March 14, 2020 the Indonesian government declared the Covid-19 outbreak a national disaster. As a result of the Covid-19 outbreak, the Indonesian government took strategic steps to prevent wider cases by issuing PSBB and PPKM policies. This policy aims to break the transmission rate of Covid-19. As an issue and problem, Covid-19 has also not escaped the attention of the Gido District government, so this study aims to find out the role of the sub-district head in preventing and controlling Corona Virus Disease (Covid-19) in Gido District, Nias Regency and to find out the obstacles experienced by the Head of Gido subdistrict in the prevention and control of Corona Virus Disease (Covid-19) in Gido District, Nias Regency. This researcher uses a qualitative method that is descriptive in nature, namely to provide a clear picture of the problem under study. Data collection techniques used are observation, interviews and documentation. The results showed that the role of the sub-district head in prevention and control was effective. This is marked by the activeness of the camat in providing advice and outreach and collaborating between various parties such as the Koramil and puskesmas as well as village government officials to jointly prevent the transmission of Covid-19 and provide health facilities for the community such as masks and hand sanitizers. The sub-district head also took firm action against immigrants to self-isolate. The sub-district head also plays a role in monitoring the process of recusing village funds to be diverted to communities affected by Covid-19 so that people can receive social assistance evenly. The inhibiting factor experienced by the sub-district head is that there are still many people who do not understand the dangers of Covid - 19 and the solution for this is that the sub-district head cooperates with the puskesmas to participate in explaining about Covid-19 and how it is transmitted as well as ways to prevent and overcome it.
Implementasi Kebijakan Pengembangan Potensi Wisata Sungai Bukit Lawang Pada Dinas Pariwisata Kabupaten Langkat
Authors: Astuti Nadya Sri , Wulandari Novita , Lubis Khairunnisa
Published: March 2024

This research is motivated by the not yet optimal implementation of policies regarding development of the Sungai Bukit Lawang Tourism Destination by the Langkat Regency Tourism Office. This is due to the lack of facilities and infrastructure to support tourism development. This study aims to describe and determine the implementation of policies at the Langkat Regency Tourism Office. As well as to find out the supporting and inhibiting factors of policy implementation at the Langkat Regency Tourism Office. This study analyzes first by analysis (Edwards III, 1980: 1). The research method used is descriptive qualitative method. The informants of this study were 7 informants. Data collection techniques using field studies (observations, interviews, and documentation).This can be seen based on the opinion of the informant who stated that there is still a lack of facilities and infrastructure provided directly by the agency. There are perceived obstacles such as budget constraints, difficulty applying tasks according to SOP to the community.
Gaya Kepemimpinan Kepala Desa Madani Kecamatan Sorkam Barat Dalam Meningkatkan Produktivitas Kinerja Aparatur Pemerintah Desa
Authors: Silaban Edo Joshep Putra , Mustafa Walid , Kurniaty Evi Yunita
Published: March 2024

Madani Village is located in West Sorkam Barat District, Tapanuli Tengah Regency. This research started from the researcher's interest in seeing the importance of a leader's leadership style as a determining factor in the success or failure of an organization, both governmental and non-governmental, especially in Madani Village, Sorkam Barat District, Tapanuli Tengah Regency. aims to see Most of the people how the leadership style of the village head in increasing the productivity of village apparatus performance and what factors increase the productivity of village government apparatus performance in Madani Village, Sorkam Barat District, Tapanuli Tengah Regency. The results of the study indicate that the Madani village head applies a mixed, democratic and supervisory leadership style, with this leadership style strengthening the relationship between leaders and subordinates such as involving subordinates in decision making. Then it is strengthened by the existence of several factors driving the productivity of the performance of village government apparatus such as ability or skill factors, cultural and environmental factors and leadership style factors, and the most dominant of these three factors is the leadership style factor because with a leader there is someone who gives encouragement, input. and guidance to subordinates or apparatus at work.
Peran Pemerintah Dalam Pengelolaan Pariwisata Di Desa Sippan Tiga Raja Pamatang Silimahuta Kabupaten Simalungun
Authors: Br Siregar Novita Ratna Sari , Hartono Budi , Wulandari Novita
Published: March 2024

Anugerah Indah Sippan Tourism is a natural destination that offers the charm of a hill in the Saribu Dolok area.. Even though it has just opened, Anugerah Indah Sippan Tourism is a favorite vacation location on weekends. This is because many distinctive charms can be found such as stunning views of the surrounding natural orchestra, a garden on a hill and cool fresh air. However, there are several problems such as accessibility and infrastructure facilities for the Sippan Village tourist attraction, which are still lacking in attention from the government. In this case, the Simalungun Regency Tourism and Culture Office as the manager of the Sippan Village tourist attraction has an important role in managing village tourism objects. The theory used in this study is the role theory by Pitana and Gayatri (2005:95), this research uses a qualitative type methodology that uses interview techniques, observation, and also documentation. As reinforcement, this study also consisted of key informants, main informants and additional informants using data analysis techniques by Miles and Hubermen namely data collection, data reduction, data presentation and conclusions. The purpose of this study was to determine the role and constraints of the Simalungun Regency Tourism and Culture Office in tourism management
EFFECT OF QUERCETIN ON PERIRENAL ADIPOSE TISSUE ADIPONECTIN AND RESISTIN LEVELS IN RATS FED A HIGH FRUCTOSE-DIET
Authors: KILIÇ TOPRAK Emine , TUNÇ-ATA Melek
Published: March 2024

Obesity is defined as the accumulation of adipose tissue to excess and to an extent that impairs both physical and psychosocial health and well-being. The increase in adipose tissue observed in obesity causes proinflammatory and anti-inflammatory cytokine imbalance. Accumulating evidence on quercetin, one of the antioxidants frequently used in obesity treatment, suggests that quercetin has significant anti-obesity and lipid-lowering effects simultaneously. We hypothesized that quercetin supplementation could improve obesity parameters and restore adipokine balance in obese mice. Sprague Dawley rats, 8-10 weeks of age, were divided into 4 groups, including a control group (C), high fructose (HF) group, quercetine (Q) group, and high fructose+quercetin (HF+Q) group. Fructose was administered to HF groups as a 20% solution in drinking water for 6 weeks. The rats in the Q groups were given 50 mg quercetin per kg BW by gavage for the next 4 weeks. The body weight, lee index, TG, HDL, fasting insülin, fasting glucose, and HOMA-IR were determined in rats. ADP and resistin levels were determined by ELISA assay from perirenal adipose tissue homogenates. We showed that quercetin acts to improve TG, fasting glucose and insulin resistance in high fructose-fed rats. In this study, we found no effect of quercetin on perirenal adipose tissue ADP and resistin levels. These results showed that high fructose could induce obesity in rats, while quercetin could favorably affect these parameters.