bluuebunny/crossref_metadata_2025 huggingface dataset:
Maxillofacial prosthodontics practice profile: A survey of non-United States prosthodontists
Authors: Ariani Nina , Reintsema Harry , Ward Kathleen , Sukotjo Cortino , Wee Alvin G.
Published: April 2017

Background

This study surveyed non-United States maxillofacial prosthodontists (MFP) to determine their practice profile and rationale for pursuing an MFP career.

Methods

Email addresses for the MFP were obtained from the International Society for Maxillofacial Rehabilitation, American Academy of Maxillofacial Prosthetics, and International Academy for Oral Facial Rehabilitation. Emails with a link to the electronic survey program were sent to each participant. Chi-square and Mann–Whitney-U tests were used to investigate the influence of formal MFP training on professional activities and type of treatments provided.

Results

One hundred twelve respondents (response rate 39%) from 33 nationalities returned the survey. The top three reasons for pursuing an MFP career were personal satisfaction, prosthodontics residency exposure, and mentorship. The predominant employment setting was affiliation with a university (77%). There were significant differences between respondents with and without formal MFP training regarding provision of surgical treatments ( P = 0.021) and dental oncology ( P = 0.017). Most treatments were done together with otolaryngology, oral surgery (68%) and head and neck surgery (61%). Practitioners not affiliated with a university spent significantly more time in clinical practice ( P = 0.002), whereas respondents affiliated with universities spent significantly more time in teaching/training ( P = 0.008) and funded research ( P = 0.015).

Conclusions

Personal satisfaction is the most important factor in a decision to choose an MFP career. Most of the MFPs work at a university and within a multidisciplinary setting. There were differences regarding type of treatments provided by respondents with and without formal MFP training.
Streamer depth versus vessel and seismic interference noise
Authors: Dao Toan , Landrø Martin
Published: April 2017

For marine seismic surveying, it is commonly assumed that the noise level decreases with depth. In addition, recent advances in broadband seismic have shown that a greater receiver depth is beneficial in preserving low-frequency data. However, in a heavily trafficked ocean, noise from other ships, including seismic interference, is a counteractive process in which the noise actually varies with depth. Normal modes can be used to explain and predict the ship noise and seismic interference noise level. We find that weather noise is dominant below the first mode’s cutoff frequency (approximately 6 Hz), ship noise is dominant from that frequency to the upper end of the useful seismic frequency band (80 Hz). We have used a data set in which the streamer was towed at 8, 45, and 60 m depths in three passes over the same area in the North Sea. The water depth is 135 m on average. We observe that the noise level at 45 and 60 m depth is approximately 1.6 times stronger than that at 8 m. We find that the air-gun energy is up to 46 dB stronger than the noise from the seismic vessel. However, the total noise from all the ships within several hundred kilometers radius can reduce the data quality.
Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non–Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy
Authors: Shepherd Frances A. , Lacas Benjamin , Le Teuff Gwénaël , Hainaut Pierre , Jänne Pasi A. , Pignon Jean-Pierre , Le Chevalier Thierry , Seymour Lesley , Douillard Jean-Yves , Graziano Stephen , Brambilla Elizabeth , Pirker Robert , Filipits Martin , Kratzke Robert , Soria Jean-Charles , Tsao Ming-Sound ,   on behalf of the LACE-Bio Collaborative Group
Published: April 2017

Purpose

Our previous work evaluated individual prognostic and predictive roles of TP53, KRAS, and EGFR in non–small-cell lung cancer (NSCLC). In this analysis, we explore the prognostic and predictive roles of TP53/KRAS and TP53/EGFR comutations in randomized trials of adjuvant chemotherapy versus observation.

Patients and Methods

Mutation analyses (wild-type [WT] and mutant) for TP53, KRAS, and EGFR were determined in blinded fashion in multiple laboratories. Primary and secondary end points of pooled analysis were overall survival and disease-free survival. We evaluated the role of TP53/KRAS comutation in all patients and in the adenocarcinoma subgroup as well as the TP53/EGFR comutation in adenocarcinoma only through a multivariable Cox proportional hazards model stratified by trial.

Results

Of 3,533 patients with NSCLC, 1,181 (557 deaths) and 404 (170 deaths) were used for TP53/KRAS and TP53/EGFR analyses. For TP53/KRAS mutation status, no prognostic effect was observed ( P = .61), whereas a borderline predictive effect ( P = .04) was observed with a deleterious effect of chemotherapy with TP53/KRAS comutations versus WT/WT (hazard ratio, 2.49 [95% CI, 1.10 to 5.64]; P = .03). TP53/EGFR comutation in adenocarcinoma was neither prognostic ( P = .83), nor significantly predictive ( P = .86). Similar results were observed for both groups for disease-free survival.

Conclusion

We could identify no prognostic effect of the KRAS or EGFR driver and TP53 tumor suppressor comutation. Our observation of a potential negative predictive effect of TP53/KRAS comutation requires validation.
Comparison of Postoperative Respiratory Monitoring by Acoustic and Transthoracic Impedance Technologies in Pediatric Patients at Risk of Respiratory Depression
Authors: Patino Mario , Kalin Megan , Griffin Allison , Minhajuddin Abu , Ding Lili , Williams Timothy , Ishman Stacey , Mahmoud Mohamed , Kurth C. Dean , Szmuk Peter
Published: April 2017

BACKGROUND:

In children, postoperative respiratory rate (RR) monitoring by transthoracic impedance (TI), capnography, and manual counting has limitations. The rainbow acoustic monitor (RAM) measures continuous RR noninvasively by a different methodology. Our primary aim was to compare the degree of agreement and accuracy of RR measurements as determined by RAM and TI to that of manual counting. Secondary aims include tolerance and analysis of alarm events.

METHODS:

Sixty-two children (2–16 years old) were admitted after tonsillectomy or receiving postoperative patient/parental-controlled analgesia. RR was measured at regular intervals by RAM, TI, and manual count. Each TI or RAM alarm resulted in a clinical evaluation to categorize as a true or false alarm. To assess accuracy and degree of agreement of RR measured by RAM or TI compared with manual counting, a Bland–Altman analysis was utilized showing the average difference and the limits of agreement. Sensitivity and specificity of RR alarms by TI and RAM are presented.

RESULTS:

Fifty-eight posttonsillectomy children and 4 patient/parental-controlled analgesia users aged 6.5 ± 3.4 years and weighting 35.3 ± 22.7 kg (body mass index percentile 76.6 ± 30.8) were included. The average monitoring time per patient was 15.9 ± 4.8 hours. RAM was tolerated 87% of the total monitoring time. The manual RR count was significantly different from TI (P= .007) with an average difference ± SD of 1.39 ± 10.6 but were not significantly different from RAM (P= .81) with an average difference ± SD of 0.17 ± 6.8. The proportion of time when RR measurements differed by ≥4 breaths was 22% by TI and was 11% by RAM. Overall, 276 alarms were detected (mean alarms/patient = 4.5). The mean number of alarms per patient were 1.58 ± 2.49 and 2.87 ± 4.32 for RAM and TI, respectively. The mean number of false alarms was 0.18 ± 0.71 for RAM and 1.00 ± 2.78 for TI. The RAM was found to have 46.6% sensitivity (95% confidence interval [CI], 0.29–0.64), 95.9% specificity (95% CI, 0.90–1.00), 88.9% positive predictive value (95% CI, 0.73–1.00), and 72.1% negative predictive value (95% CI, 0.61–0.84), whereas the TI monitor had 68.5% sensitivity (95% CI, 0.53–0.84), 72.0% specificity (95% CI, 0.60–0.84), 59.0% positive (95% CI, 0.44–0.74), and 79.5% negative predictive value (95% CI, 0.69–0.90).

CONCLUSIONS:

In children at risk of postoperative respiratory depression, RR assessment by RAM was not different to manual counting. RAM was well tolerated, had a lower incidence of false alarms, and had better specificity and positive predictive value than TI. Rigorous evaluation of the negative predictive value is essential to determine the role of postoperative respiratory monitoring with RAM.
Dictatorial Rule and Sexual Politics in Argentina: The Case of the Frente de Liberación Homosexual, 1967–1976
Authors: Ben Pablo , Insausti Santiago Joaquin
Published: April 2017

The Frente de Liberación Homosexual (FLH, 1967–1976) was the first political movement of homosexual men in Argentina. Despite its short life span, this organization set the ground for future developments. The FLH emerged in the context of increasing authoritarianism rather than being the result of a transition to democracy. The relationship with homophobic Peronists and left-wing traditions was, paradoxically, crucial for the emergence of the FLH. Most homosexual activists came from the Left, and they understood homosexual liberation as one aspect of the struggle against capitalism. These activists were highly critical of anticapitalist politics as it existed in Argentina at the time, but they also actively sought to become allies of the expanding New Left during the period. Eventually, however, the 1976–1983 military dictatorship made all forms of dissidence impossible, and the FLH had to dissolve.
Obituary: Tokindo S. Okada (1927-2017)
Authors: Kondoh Hisato , Nakamura Harukazu
Published: April 2017

Hisato Kondoh and Harukazu Nakamura look back at the life and career of their mentor Tokindo S. Okada, a pioneer of Japanese developmental biology.
Paneth cell disruption-induced necrotizing enterocolitis requires live bacteria and occurs independent of TLR4 signaling
Authors: White Jessica R. , Gong Huiyu , Pope Brock , Schlievert Patrick , McElroy Steven J.
Published: April 2017

Objective

Necrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality in premature infants. Both human surgical specimens and animal models suggest a potential involvement of Paneth cells in NEC pathogenesis. Paneth cells play critical roles in epithelial homeostasis, innate immunity, and host-microbial interactions. Yet, the complex interplay between Paneth cell disruption, epithelial barrier dysfunction, and microbial-driven inflammation remains unclear in the immature intestine.

Design

Mucosal intestinal injury consistent with human NEC was induced in P14-16 mice by disrupting Paneth cells, followed by gavage of Klebsiella pneumonia. Mucosal injury was determined by histology, serum cytokine levels, and epithelial barrier dysfunction. TLR4 activation was examined using protein expression, gene expression, and TLR4−/- mice. Finally, the role of bacteria was evaluated using heat-killed bacteria, conditioned media, Bacillus cereus, and cecal slurries.

Results

Live bacteria were required to induce injury, however TLR4 activation was not required. Paneth cell disruption-induced NEC induces altered localization of tight junction proteins and subsequent loss of barrier function.

Conclusions

Prior research has shown a requirement of TLR4 activation to induce NEC-like damage. However, many infants develop NEC in the absence of Gram negative rod bacteremia raising the question of alternate pathways to intestinal injury. In this data, we show a novel mechanism for development of intestinal injury equivalent to that seen in human NEC and is not dependent on TLR4 pathways. These data are congruent with the new hypothesis that NEC may be the consequence of several disease processes ending in a final common inflammatory pathway.
Honeybees use the skyline in orientation
Authors: Towne William F. , Ritrovato Antoinette E. , Esposto Antonina , Brown Duncan F.
Published: April 2017

In view-based navigation, animals acquire views of the landscape from various locations and then compare the learned views with current views in order to orient in certain directions or move toward certain destinations. One landscape feature of great potential usefulness in view-based navigation is the skyline, the silhouette of terrestrial objects against the sky, as it is distant, relatively stable, and easy to detect. The skyline has been shown to be important in the view-based navigation of ants, but no flying insect has yet been shown definitively to use the skyline in this way. Here we show that honeybees do indeed orient using the skyline. A feeder was surrounded with an artificial replica of the natural skyline there, and the bees' departures toward the nest were recorded from above with a video camera under overcast skies (to eliminate celestial cues). When the artificial skyline was rotated, the bees' departures were rotated correspondingly, showing that the bees oriented by the artificial skyline alone. We discuss these findings in the context of the likely importance of the skyline in long-range homing in bees, the likely importance of altitude in using the skyline, the likely role of ultraviolet light in detecting the skyline, and what we know about the bees' abilities to resolve skyline features.
Less Is More: Harnessing Product Substitution Information to Rationalize SKUs at Intcomex
Authors: Bernales Patxi J. , Guan Yongtao , Natarajan Harihara Prasad , Gimenez Patricia Souza , Tajes Mario Xavier Alvarez
Published: April 2017

Intcomex, a large global distributor of information technology products, was experiencing severe stress in its supply chain from a rapidly expanding set of products in its catalog. The company proactively partnered with an academic team to develop a data-driven approach to address this issue. Rather than adopt potentially suboptimal rules of thumb for product selection (and exclusion), the project team developed a composite method for rationalizing stock-keeping units (SKUs). This approach allows the company to statistically estimate product demand and product substitution using profit-based optimization of the product selection decision. Intuitively, the approach seeks to leverage the company’s ability to substitute products by eliminating low-profit SKUs for which substitutes are available. It accounts for all costs incurred over a product’s life cycle, incorporates other important contextual considerations, and delivers tailored recommendations for each product category and geographical market. We implemented the composite method as two software modules—one for statistical estimation and one for assortment optimization. Using the software tools of the composite method on a product category in the company’s Uruguay operations, we generated an 18 percent increase in profits from rationalizing the company’s product catalog. Despite the streamlined catalog, more than 97.5 percent of the product demand was served; in addition, revenues increased because of the better match between supply and demand.
Do Stock Returns Really Decrease with Default Risk? New International Evidence
Authors: Aretz Kevin , Florackis Chris , Kostakis Alexandros
Published: April 2017

This study constructs a novel data set of bankruptcy filings for a large sample of non-U.S. firms in 14 developed markets and sheds new light on the cross-sectional relation between default risk and stock returns. Using the reduced-form approach of Campbell et al. (2008) to estimate default probabilities, we offer conclusive evidence supporting the existence of a significant positive default risk premium in international markets. This finding is robust to different portfolio weighting schemes, data filters, risk-adjusting approaches, and holding period definitions. Decomposing the default risk measure into its systematic and idiosyncratic components, we find that the former drives this positive relation. We also show that the default risk premium is more pronounced in countries where creditor protection is stronger and shareholder bargaining power is lower.

The online appendix is available at https://doi.org/10.1287/mnsc.2016.2712 .

This paper was accepted by Amit Seru, finance.
Self-Regulation of an Unobservable Queue
Authors: Haviv Moshe , Oz Binyamin
Published: April 2017

We consider an unobservable M/M/1 queue where customers are homogeneous with respect to service valuation and cost per unit time of waiting. It is well known that left to themselves, in equilibrium, customers join the queue at a rate higher than is socially optimal. Hence, regulation schemes, under which the resulting equilibrium joining rate coincides with the socially optimal one, should be considered. We suggest a classification of regulation schemes based on a few desired properties and use it to classify schemes from the existing literature. To the best of our knowledge, none of the existing schemes possesses all of the properties, and in this paper we suggest such a scheme. Its novelty is in assigning random priorities to customers, prior to their decision whether to join or balk. We also introduce variations of this regulation scheme as well as others that are also based on randomization.

The e-companion is available at https://doi.org/10.1287/mnsc.2017.2728 .

This paper was accepted by Gad Allon, operations management.
Optimal Dynamic Auctions for Display Advertising
Authors: Chen Ying-Ju
Published: April 2017

In this paper, we investigate the optimal dynamic auction design for the display advertising industry. Currently, display advertising is sold through two markets side by side. In the traditional guaranteed market, the publisher commits to deliver a prespecified number of impressions within a fixed time frame through a guaranteed contract. In the spot market, the publisher runs an auction to allocate the impressions every period, and the supply of heterogeneous impressions is highly uncertain and nonstorable. Thus, the publisher must solve a dynamic capacity allocation problem of heterogeneous impressions across different contracts and markets, taking into account the uncertainties from both the demand and supply sides.

We characterize the precise trade-offs between extracting the revenue from the spot markets, materializing the instantaneous benefit shared with the guaranteed advertisers, and releasing the pressure of paying the penalty related to guaranteed contracts. Furthermore, we identify the dual role of the publisher as a system designer and as a bidder on behalf of the guaranteed advertisers. With heterogeneous due dates of guaranteed contracts, we demonstrate the inherent scheduling issue embedded in this dynamic revenue management problem, and completely solve the joint scheduling and capacity allocation problem for some special cases.

The online appendix is available at https://doi.org/10.1287/opre.2017.1592 .
Ecological Studies of Barwala Link Canal in Narwana Region, Haryana
Authors: Tyor Anil , Devi Parmila
Published: April 2017

The present paper deals with the monthly variations in physico-chemical characteristics and planktonic diversity of Barwala Link Canal which link the Bhakra Main Canal with Sirsa Branch of Western Yamuna Canal in Narwana Region, Haryana. Surface water samples were collected on monthly basis and analyzed for physico-chemical parameters (water temperature, total dissolved solids, electrical conductivity, turbidity, pH, dissolved oxygen, free CO2, alkalinity, hardness, chlorides, biochemical oxygen demand, o-phosphate, nitrate and ammonia). An attempt was also made to assess the biological parameters including population density, their abundance and species diversity index of plankton life which were used as a measure of water quality. Phytoplankton was abundant as compared to Zooplankton. A total of 14 taxa of phytoplankton were recorded of which 9 taxa of Chlorophyceae and 5 taxa of Bacillariophyceae. 8 taxa of zooplankton were recorded of which 4 taxa of protozoa, 3 taxa of rotifera and one taxa of insecta. Shannon diversity index of phytoplankton ranges from 2.47 to 3.29 and Zooplankton ranges from 2.60 to 2.99. It is revealed that the quality of canal water is good throughout study period as estimated by the weighted arithmetic index method.
Views from the front line: is the NHS workforce at crisis point?
Authors: Glasper Alan
Published: April 2017

Emeritus Professor Alan Glasper, from the University of Southampton, discusses a report revealing that hospital doctors are concerned about their ability to deliver safe patient care over the next 12 months
Indemnity – how much protection do I need?
Authors: Collier Andrew
Published: April 2017

Dental nurses may feel increasingly worried about their potential liability regarding complaints, claims or General Dental Council (GDC) action against them. Andrew Collier considers potential risks and how to protect your professional status
The impact of
Authors: Sharma Priya
Published: April 2017

Priya Sharma considers a very real concern in children's dental health
Taking the lead
Authors: Bridges Glenys
Published: April 2017

Glenys Bridges considers the steps towards developing the role of lead dental nurse
The changing landscape of orthodontics
Authors: Pretty Lorraine
Published: April 2017

Lorraine Pretty considers what a shift in patient base means for oral health
Retraction
Authors: Haddad F. S.
Published: April 2017

Su EP Post-operative neuropathy after total hip arthroplasty. Bone Joint J 2017;99-B:(1 Supple A):46-49.
Errata
Authors: Haddad F. S.
Published: April 2017

van der Vegt AE, Grond R, Grüschke JS, Boomsma MF, Emmelot CH, Dijkstra PU, van der Sluis CK. The effect of two different orthoses on pain, hand function, patient satisfaction and preference in patients with thumb carpometacarpal osteoarthritis. Bone Joint J;2017;99-B:237-244.
Synovial calprotectin
Authors: Wouthuyzen-Bakker M. , Ploegmakers J. J. W. , Kampinga G. A. , Wagenmakers-Huizenga L. , Jutte P. C. , Muller Kobold A. C.
Published: April 2017

Aims

Recently, several synovial biomarkers have been introduced into the algorithm for the diagnosis of a prosthetic joint infection (PJI). Alpha defensin is a promising biomarker, with a high sensitivity and specificity, but it is expensive. Calprotectin is a protein that is present in the cytoplasm of neutrophils, is released upon neutrophil activation and exhibits anti-microbial activity. Our aim, in this study, was to determine the diagnostic potential of synovial calprotectin in the diagnosis of a PJI.

Patients and Methods

In this pilot study, we prospectively collected synovial fluid from the hip, knee, shoulder and elbow of 19 patients with a proven PJI and from a control group of 42 patients who underwent revision surgery without a PJI. PJI was diagnosed according to the current diagnostic criteria of the Musculoskeletal Infection Society. Synovial fluid was centrifuged and the supernatant was used to measure the level of calprotectin after applying a lateral flow immunoassay.

Results

The median synovial calprotectin level was 991 mg/L (interquartile range (IQR) 154 to 1787) in those with a PJI and 11 mg/L (IQR 3 to 29) in the control group (p < 0.0001). Using a cut-off value of 50 mg/L, this level showed an excellent diagnostic accuracy, with an area under the curve of 0.94. The overall sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) was 89%, 90%, 81% and 95% respectively. The NPV was 97% in the nine patients with a chronic PJI.

Conclusion

Synovial calprotectin may be a valuable biomarker in the diagnosis of a PJI, especially in the exclusion of an infection. With a lateral flow immunoassay, a relatively rapid quantitative diagnosis can be made. The measurement is cheap and is easy to use. Cite this article: Bone Joint J 2017;99-B:660–5.
Mass Spectrometry but Not Fluorimetry Distinguishes Affected and Pseudodeficiency Patients in Newborn Screening for Pompe Disease
Authors: Liao Hsuan-Chieh , Chan Min-Ju , Yang Chia-Feng , Chiang Chuan-Chi , Niu Dau-Ming , Huang Chun-Kai , Gelb Michael H
Published: April 2017

BACKGROUND

Deficiency of the lysosomal enzyme acid α-glucosidase (GAA) causes Pompe disease. Newborn screening for Pompe disease is ongoing, and improved methods for distinguishing affected patients from those with pseudodeficiency, especially in the Asian population, would substantially reduce the number of patient referrals for clinical follow-up.

METHODS

We measured the enzymatic activity of GAA in dried blood spots on newborn screening cards (DBS) using a tandem mass spectrometry (MS/MS) assay. The assay displayed a relatively large analytical range compared to the fluorimetric assay with 4-methylumbelliferyl-α-glucoside. DBS from newborns confirmed to have infantile-onset Pompe disease (IOPD, n = 11) or late-onset Pompe disease (LOPD) (n = 12) and those from patients bearing pseudodeficiency alleles with or without Pompe mutations, or Pompe disease carriers (n = 230) were studied.

RESULTS

With use of the MS/MS GAA assay in DBS, 96% of the pseudodeficiency newborns and all of the Pompe disease carriers were well separated from the IOPD and LOPD newborns. The fluorimetric assay separated <10% of the pseudodeficiencies from the IOPD/LOPD group.

CONCLUSIONS

The relatively large analytical range MS/MS GAA assay but not the fluorimetric assay in DBS provides a robust approach to reduce the number of referrals and should dramatically facilitate newborn screening of Pompe disease.
Samurai masculinity, Japan’s self defence force and the uncanny space–time of Sengoku Jieitai
Authors: McKissack Fraser
Published: April 2017

The image of contemporary Japanese men fighting alongside samurai warriors is impossible, but not simply because time-travel does not exist. As I argue in this article, Japan is tethered to an historical narrative of samurai virtue that can no longer exist. This is a paradox that threatens to destabilize Japan’s contemporary military spaces and its contested history of militarism. I explore this paradox through the concept of Japan’s military space–time, which draws attention to the spatial and temporal dimensions of Japan’s demilitarization and the tensions that arise when a demilitarized space coexists with a militant history and the legacy of Japan’s epitomic masculine figure, the samurai. In order for contemporary Japanese SDF personnel to identify with the samurai they inevitably encounter the spectre of Japan’s twentieth–century militarism, and thus the samurai returns to the present as an uncanny embodiment of a repressed masculine self. Through the close analysis of two Japanese time-travel films, Sengoku Jieitai (Saitō, 1979) and Sengoku Jieitai: 1549 (Tezuka, 2005), I demonstrate how the attempt to reconcile Japan’s contemporary pacifist identity with its feudal past threatens to rupture the narrative of a cohesive national selfhood.
Total Anomalous Pulmonary Venous Connection in Children: Preoperative Evaluation with Low-Dose Multidetector Computed Tomographic Angiography
Authors: Turkvatan Aysel , Tola Hasan Tahsin , Ayyildiz Pelin , Ozturk Erkut , Ergul Yakup , Guzeltas Alper
Published: April 2017

We report the results of our retrospective evaluation, from February 2011 through August 2014, of the anatomic features of total anomalous pulmonary venous connection (TAPVC) and its associated cardiovascular anomalies in a pediatric population. In all 43 patients under study (23 female; average age, 9 mo [range, 4 d–7.1 yr]), these examinations had been performed with a dual-source 256-detector scanner.

The type of TAPVC, the presence of obstruction, and the association with other cardiovascular anomalies were investigated and recorded. In accordance with the absence or presence of these accompanying anomalies, patients were subdivided into 2 groups: isolated and complex.

In the 43 patients, 22 (51%) TAPVCs were supracardiac, 10 (23%) were cardiac, 6 (14%) were infracardiac, and 5 (12%) were mixed. Obstruction was detected in 7 patients. Seventeen patients were in the isolated group and 26 in the complex group. The diagnostic agreements between multidetector computed tomographic angiographic and surgical results were 100% in both the isolated and complex groups. The overall average effective radiation dose was 0.66 mSv (range, 0.15–1.11 mSv); and it was 0.52 mSv (range, 0.12–0.72 mSv) in patients younger than 1 year of age.

We conclude that computed tomographic angiography with a dual-source 256-slice multidetector scanner is a reliable imaging method that enables, despite lower radiation doses, the detailed and comprehensive anatomic imaging of TAPVC in neonates and children.
Surgical Treatment of Constrictive Pericarditis
Authors: Depboylu Burak Can , Mootoosamy Parmeseeven , Vistarini Nicola , Testuz Ariane , El-Hamamsy Ismail , Cikirikcioglu Mustafa
Published: April 2017

Constrictive pericarditis is the final stage of a chronic inflammatory process characterized by fibrous thickening and calcification of the pericardium that impairs diastolic filling, reduces cardiac output, and ultimately leads to heart failure.

Transthoracic echocardiography, computed tomography, and cardiac magnetic resonance imaging each can reveal severe diastolic dysfunction and increased pericardial thickness. Cardiac catheterization can help to confirm a diagnosis of diastolic dysfunction secondary to pericardial constriction, and to exclude restrictive cardiomyopathy.

Early pericardiectomy with complete decortication (if technically feasible) provides good symptomatic relief and is the treatment of choice for constrictive pericarditis, before severe constriction and myocardial atrophy occur.

We describe our surgical approach to constrictive pericarditis, summarize our results in 93 patients, and provide a brief overview of the literature.
A Rare Case of Vascular Ring and Coarctation of the Aorta in Association with CHARGE Syndrome
Authors: Wagner Jonathan B. , Knowlton Joshua Q. , Pastuszko Peter , Shah Sanket S.
Published: April 2017

A male neonate presented with CHARGE syndrome, a multiorgan genetic disorder involving the Coloboma of the eyes, congenital Heart defects, nasal choanal Atresia, growth and development Retardation, Genitourinary disorders, and Ear anomalies and deafness. Moreover, he had a rare case of vascular ring—consisting of a right aortic arch with retroesophageal brachiocephalic artery—combined with coarctation of the mid-aortic arch. He underwent both vascular ring and aortic arch repair at our institution.

To our knowledge, this is the 4th documented case of this exceedingly rare type of aortic arch anomaly combined with aortic arch obstruction. Moreover, it is the first confirmed case of these combined disorders occurring in CHARGE syndrome.

This report describes a truly rare case and reveals the limitations of echocardiography in detecting complex aortic arch anomalies while illustrating the benefits of advanced imaging prior to surgical intervention.
Nonidentical Continuous-Flow Devices For Biventricular Support
Authors: Baldwin Andrew C.W. , Sandoval Elena , Cohn William E. , Mallidi Hari R. , Morgan Jeffrey A. , Frazier O.H.
Published: April 2017

Although biventricular heart failure has been successfully managed with dual continuous-flow ventricular assist devices, the long-term use of 2 mechanically dissimilar pumps has traditionally been discouraged. We present the case of a 52-year-old man whose treatment with a HeartMate II left ventricular assist device was complicated by right ventricular failure, necessitating the implantation of a long-term right ventricular assist device. A HeartWare left ventricular assist device was placed along the right ventricular base to avoid interference with the HeartMate II housing. The patient was discharged from the hospital after routine postoperative care and dual-device training. This case shows that, despite logistical complexities, nonidentical continuous-flow device pairings can successfully provide long-term biventricular support.
Percutaneous Closure of 2 Paravalvular Leaks and a Gerbode Defect after Mitral Valve Replacement for Infective Endocarditis
Authors: Peñalver Jorge , Shatila Wassim , Silva Guilherme V.
Published: April 2017

Surgical valve replacement after infective endocarditis can result in local destructive paravalvular lesions.

A 30-year-old woman with infective endocarditis underwent mitral valve replacement that was complicated postoperatively by 2 paravalvular leaks. During percutaneous closure of the leaks, a Gerbode defect was also found and closed. We discuss our patient's case and its relation to others in the relevant medical literature. To our knowledge, we are the first to describe the use of a percutaneous approach to close concomitant paravalvular leaks and a Gerbode defect.
Nina Braunwald: A Female Pioneer in Cardiac Surgery
Authors: Sabharwal Nikhil , Dev Harmanjit , Smail Hassiba , McGiffin David C. , Saxena Pankaj
Published: April 2017

Nina Starr Braunwald, the first female cardiac surgeon, made headlines during a time when almost all specialty surgeons were men.

Women have typically been deterred from entering surgical specialties, in part because of their traditional dual burden of managing their households and careers. Instead, female medical students and junior doctors have tended to be more attracted to medical specialties. This was the reality during Dr. Braunwald's venture into medicine in 1949. However, she never allowed negative ideas to keep her from joining a surgical training program.

Under the mentorship of the prominent cardiac surgeons Charles Hufnagel and Andrew Morrow, Dr. Braunwald progressed in her career by conducting research that led to her development and implantation of the first prosthetic mitral valve. She was also a great teacher.

Dr. Braunwald balanced her personal and professional activities admirably, and her example still inspires female doctors to consider careers in cardiothoracic surgery. In this report, we provide details of her impact on cardiac surgery and insights into her successes.
CO2-Abscheidung und -Lagerung im Überblick – Technik, Potenziale, Risiken, Kosten und RegulierungA Review of Carbon Dioxide Capture and Storage – Technology, Potentials, Risks, Costs, and Regulation
Authors: Grünwald Reinhard
Published: April 2017

Ist CCS - die Abscheidung und Lagerung von CO2 - die Lösung des Klima - problems oder nur ein Nebenton im Konzert der Klimaschutzoptionen? Steht die Techno logie kurz vor dem Durchbruch oder ist sie Zukunftsmusik? Gibt es eine Regulierung, die alle Optionen offenhält
und zugleich alle Risiken ausschließt?Recently there has been animated discussion about the contribution of carbon dioxide capture and storage (CCS) to achieve climate protection goals. This overview of the current state of knowledge and discussion about potentials, risks, environmental
impacts, costs, as well as questions on the integration of CCS into the energy system shows: There is still a considerable need for research and development until CCS is ready for deployment. Currently, while the EU and national levels invest significant energy to create a legal regulatory
framework for CCS, they are confronted with the challenge of adequately dealing with a subject characterized by a large number of "known unknowns" and "unknown unknowns".
CO2-Abscheidung und -Lagerung im Rahmen des Clean Development Mechanism: Chancen und RisikenCarbon Dioxide Capture and Storage under the Clean Development Mechanism: Opportunities and Risks
Authors: Bode Sven
Published: April 2017

To mitigate the dangerous impacts of climate change, anthropogenic CO2 emissions must be reduced drastically. In this context, carbon dioxide capture and storage (CCS) has been increasingly considered as an option. As a part of the energy and climate change package, the EU
has for the first time provided a comprehensive legal framework for the regulation of CCS at the national level. CCS can also be implemented under the Clean Development Mechanism (CDM) of the Kyoto Protocol, which allows industrial countries to fulfil part of their emission reduction targets
in developing countries. This paper explores this option, illustrating how elements of the legal framework proposed for CDM projects in the EU could be utilised, assuming CCS is approved for the CDM. Demonstration of large-scale feasibility and long-term security of storage is still lacking,
however. The German Advisory Council on Environment therefore calls for a new law addressing research instead of comprehensive regulation of commercial use under the CCS directive of the EU. To nonetheless provide developing countries with access to CCS technology, promotion as part of technology
transfer agreements is a possible alternative.
Complexity classification of the edge coloring problem for a family of graph classes
Authors: Malyshev Dmitriy S.
Published: April 2017

A class of graphs is called monotone if it is closed under deletion of vertices and edges. Any such class may be defined in terms of forbidden subgraphs. The chromatic index of a graph is the smallest number of colors required for its edge-coloring such that any two adjacent edges have different colors. We obtain a complete classification of the complexity of the chromatic index problem for all monotone classes defined in terms of forbidden subgraphs having at most 6 edges or at most 7 vertices.
On the asymptotic normality of some sums of dependent random variables
Authors: Tikhomirova Margarita I. , Chistjakov Vladimir P.
Published: April 2017

A theorem on the asymptotic normality of the sum of dependent random variables is stated and proved. Conditions of the theorem are formulated in terms of a dependency graph which characterizes the relationships between random variables. This theorem is used to prove the asymptotic normality of the sum of functions defined on subsets of elements of the stationary sequence satisfying the strong mixing condition. As an illustration of possible applications of these theorems we give a theorem on the asymptotic normality of the number of empty cells if the random sequence of cells occupied by particles is a stationary sequence satisfying the uniform strong mixing condition.
Regulation of IRE1α by the small molecule inhibitor 4μ8c in hepatoma cells
Authors: Stewart Claire , Estrada Andrea , Kim Paul , Wang Dong , Wei Yuren , Gentile Chris , Pagliassotti Michael
Published: April 2017

The unfolded protein response (UPR) is activated in response to impairments of the folding environment in the endoplasmic reticulum (ER). The most conserved arm of the UPR, inositol-requiring ER-to-nucleus signaling protein (IRE1α), has been linked to the regulation of a diverse array of cellular processes including ER-associated degradation, inflammatory signaling, cell proliferation and membrane biogenesis. Recent studies have utilized the selective, small molecule inhibitor, 4μ8c, to examine the role of IRE1α endoribonuclease (RNase) activity in various cell types including multiple myeloma, mouse embryonic fibroblasts and pancreatic beta cells [1-5]. In the present study we utilized this inhibitor to examine the role of IRE1α RNase activity in hepatoma cells (H4IIE), specifically concentrating on cell proliferation and the identification of potential off target effects under both unstressed and stressed conditions. Experiments were performed in H4IIE hepatoma cells in the absence (control conditions (LG)) or presence (LG + Thapsigargin (Thap)) of ER stress. The presence of 4μ8c decreased IRE1α RNase activity, based on reduced splicing of X-box binding protein-1 (XBP1s) and regulated IRE1α-dependent decay of mRNA in both treatments and at concentrations ranging from 10-90 μM. Cell proliferation was significantly reduced at higher concentrations (> 60 μM 4μ8c) in unstressed cells and displayed a dose-response relationship with 4μ8c in both treatments. The presence of 4μ8c did not promote cytoxicity in either of the treatment conditions but higher concentrations of the inhibitor (60 μM) were associated with apparent off-target or compensatory responses that were not observed at 10 μM. Overall, the small-molecule inhibitor, 4μ8c is an effective inhibitor of IRE1α RNase activity in H4IIE cells. Potential off-target effects associated with this inhibitor require the use of multiple inhibitor concentrations in all experiments.
Median Analysis of Repeated Measures Associated with Recurrent Events in Presence of Terminal Event
Authors: Sundaram Rajeshwari , Ma Ling , Ghoshal Subhashis
Published: April 2017

Recurrent events are often encountered in medical follow up studies. In addition, such recurrences have other quantities associated with them that are of considerable interest, for instance medical costs of the repeated hospitalizations and tumor size in cancer recurrences. These processes can be viewed as point processes, i.e. processes with arbitrary positive jump at each recurrence. An analysis of the mean function for such point processes have been proposed in the literature. However, such point processes are often skewed, leading to median as a more appropriate measure than the mean. Furthermore, the analysis of recurrent event data is often complicated by the presence of death. We propose a semiparametric model for assessing the effect of covariates on the quantiles of the point processes. We investigate both the finite sample as well as the large sample properties of the proposed estimators. We conclude with a real data analysis of the medical cost associated with the treatment of ovarian cancer.
Syntactically–driven algorithmic processing of PP-attachment ambiguity in a second language
Authors: Fukuta Junya , Aki Goto , Yusaku Kawaguchi , Akari Kurita , Daisuke Murota
Published: April 2017

This study explored whether Japanese EFL learners can utilize syntactically–driven algorithmic processing. For this purpose, the study attempted to inhibit other forms of processing (i.e., semantically–driven heuristic processing and processing with explicit knowledge) by using a self–paced reading task with priming of PP–attachment ambiguity. In the experiment, 20 highly proficient Japanese learners and 18 native speakers of English engaged in a phrase–by–phrase self–paced reading task after reading prime sentences. Although the results of non–native speakers (NNSs) showed a similar tendency to the NSs, there were slight differences between NSs and NNSs in terms of the size of the priming effects. This indicated that highly proficient Japanese EFL learners can utilize syntactically–driven algorithmic processing, but the process may be relatively “fragile” compared to that of NSs.
Equivalence of Lease and Tenancy Terminology in English and Lithuanian
Authors: Rackevičienė Sigita , Oleškevičienė Giedrė Valūnaitė , Galkutė Gabrielė
Published: April 2017

Prompted by globalization and the importance of international communication in the legal sphere, legal language acquires an increasing importance. Contract law draws special attention in the EU and worldwide, and raises a demand for harmonization of the legal terminology of different languages and legal systems. Contracts in Anglo- Saxon and Lithuanian law have similar basic elements; however, they also contain significant differences which are determined by the regulations of the legal systems in which contracts are formed. The terminology used in the contracts also presents important peculiarities. The article focuses on the terminology of lease and tenancy agreements and provides results of the contrastive semantic analysis, the aim of which is to establish the degree of equivalence of the collected English terms and their Lithuanian counterparts. All investigated English terms have synonyms, which makes the task even more complex, as most of such synonyms have certain semantic differences and may be used interchangeably only in certain contexts. The findings of the research are believed to be valuable to legal translators, as well as compilers of legal dictionaries and databases.
Capacities and Limitations of Wind Tunnel Physical Experiments on Motion and Dispersion of Different Density Gas Pollutants
Authors: Zavila Ondřej , Blejchař Tomáš
Published: April 2017

The article focuses on the analysis of the possibilities to model motion and dispersion of plumes of different density gas pollutants in lowspeed wind tunnels based on the application of physical similarity criteria, in this case the Froude number. The analysis of the physical nature of the modeled process by the Froude number is focused on the influence of air flow velocity, gas pollutant density and model scale. This gives an idea of limitations for this type of physical experiments in relation to the modeled real phenomena. The resulting statements and logical links are exemplified by a CFD numerical simulation of a given task calculated in ANSYS Fluent software.
A Design of Finite Memory Residual Generation Filter for Sensor Fault Detection
Authors: Kim Pyung Soo
Published: April 2017

In the current paper, a residual generation filter with finite memory structure is proposed for sensor fault detection. The proposed finite memory residual generation filter provides the residual by real-time filtering of fault vector using only the most recent finite measurements and inputs on the window. It is shown that the residual given by the proposed residual generation filter provides the exact fault for noisefree systems. The proposed residual generation filter is specified to the digital filter structure for the amenability to hardware implementation. Finally, to illustrate the capability of the proposed residual generation filter, extensive simulations are performed for the discretized DC motor system with two types of sensor faults, incipient soft bias-type fault and abrupt bias-type fault. In particular, according to diverse noise levels and windows lengths, meaningful simulation results are given for the abrupt bias-type fault.
The Parametrisation of Legal Terminology Concerning Child Maintenance Support in the Swedish and Polish Legal Systems
Authors: Hadryan Milena
Published: April 2017

This paper deals with translating legal terminology concerning child maintenance from Polish to Swedish. The analysis covers selected terms regulated in the Polish civil law and their possible Swedish equivalents. The method used is based on the parameterisation of legal terms, which allows the specification of terms by selected parameters, which are understood as mutually exclusive properties. The parameterised equivalents are analysed in the context of various types of recipients. This provides the basis for the choice of appropriate translation strategies. The author also discusses pragmatic equivalents featured in Rikstermbanken, the Swedish national terminological database, and those used in practice.
Three Decades of Religious Vote in Europe
Authors: Cordero Guillermo
Published: April 2017

The social sciences have often claimed the end of religiosity as one explanation for electoral behaviour in Europe. Nevertheless, left and right parties still incorporate religious and moral issues on the agenda in order to distance themselves from their opponents. This article undertakes a comparative study of 34 European democracies and examines the extent to which religious voting has diminished since the eighties. Results point to a sharp decline in the levels of religious vote until the nineties, followed by a revitalization since that time in a third of the countries included in the sample. The analysis also highlights the important role played by the political elite in activating the religious vote.
Fused thia-heterocycles via isothiocyanates. Part I. Facile synthesis of some new 1-benzothiopyran- 4-one derivatives
Authors: Barhoumi Lina M. , El-Abadelah Mustafa M. , Sabri Salim S. , Voelter Wolfgang
Published: April 2017

A selected set of new 4H-benzothiopyran-4-one derivatives 6a–h has been prepared by a one-pot reaction involving deprotonated methyl 3-oxo-3(2′,4′,5′-trichlorophenyl)propanoate 5 and the appropriate aryl or alkyl isothiocyanate. 2,4,5-Trichloroacetophenone 4, required for the synthesis of 5, is successfully prepared by Friedel–Craft’s acetylation of 1,2,4-trichlorobenzene in 82% yield. The structures of the new compounds 5 and 6a–h are based on microanalytical and spectral (NMR, MS(EI), and HRMS) data.