bluuebunny/crossref_metadata_2025 huggingface dataset:
A prospective study on the long-term storage of sputum and the recovery of nontuberculous mycobacteria
Authors: Kwon Byoung Soo , Park Jeong Su , Shin Jung-A , Kim Eun Sun , Lim Sung Yoon , Song Myung Jin , Kim Yeon-Wook , Kim Hyung-Jun , Lee Yeon Joo , Park Jong Sun , Cho Young-Jae , Yoon Ho Il , Lee Choon-Taek , Lee Jae Ho
Published: April 2023

Background:

There is little information on the optimal storage conditions for recovery of nontuberculous Mycobacterium spp. (NTM) from refrigerated sputum.

Objectives:

We investigated the storage duration that could increase the culture-positive rate of NTM isolates.

Design:

In this prospective study, we collected NTM isolates and clinical data from patients with repeated culture-positive NTM pulmonary disease (NTM-PD).

Methods:

From June 2020 to July 2021, the participants were instructed to randomly collect six sputum samples and immediately store them in a refrigerator at 4°C until the date of their clinic visit. At the outpatient visits, expectorated spot sputum samples were collected.

Results:

A total of 226 sputum samples were collected from 35 patients. The median duration of refrigeration was 6 days (maximum duration: 36 days). The overall culture-positive rate was 81.6%. While there was a trend for a higher culture positivity rate when stored for ⩽3 weeks, this was not significant compared with those stored for >3 weeks ( p = 0.610). According to sputum microscopy, smear-positive sputum was 100% isolated, but smear-negative samples had a culture-positive rate of 77.5%. Similarly, there was no significant association between sputum storage duration and culture positivity ( p = 0.511). In addition, the recovery rate of the refrigerated sputum was comparable with the collected spot expectorated sputum (82.6% versus 80.6%, p = 0.795), which is suggestive of the long-term viability of NTM in refrigerated sputum.

Conclusion:

Our data demonstrated the long-term viability of refrigerated NTM, and the culture positivity rate of these samples was comparable with the spot expectorated sputum. These results suggest that implementing sputum refrigeration would enhance convenience in diagnosing and following patients with NTM-PD.

Plain language summary

Easy way to diagnose NTM lung diseases Under usual circumstances, most patients with suspected NTM submit spontaneously expectorated sputum rather than induced sputum for the purpose of testing the causative organism. By collecting and storing sputum specimens for a longer period than before, it is expected that more sufficient and adequate collection of sputum specimens will be possible.
Gastrointestinal injury induced by immunomodulators: A review article
Authors: Zhang Pingxin , Mao Ren , Zhang Chuhan , Qiu Yun , Chen Minhu
Published: April 2023

An increasing number of immunomodulators, either anti-inflammatory or immunity-enhancing, have brought about a revolutionary effect in the management of a variety of autoimmune disorders and malignancies. However, their ability to cause gastrointestinal (GI) injury and induce GI symptoms has been increasingly and unexpectedly recognized. GI injury associated with immunomodulators may demonstrate various histologic and endoscopic patterns. Optimal diagnosis and treatment require a multidisciplinary approach. This review aims to provide an overview of the literature on its pathogenesis, the clinical, endoscopic, and histologic features, and suggested approaches to manage these newly recognized immunomodulator-induced GI adverse effects (AEs). We also reviewed current biomarkers predictive of GI toxicity and potential risk factors to identify susceptible patients. In addition, these immune-mediated AEs were compared with inflammatory bowel disease, a well-documented form of inflammation-driven GI injury. We hope this review will raise awareness and vigilance among clinicians of these entities to increase early diagnosis and rapid referral to specialist care.
Early predictive value of scoring systems and routine laboratory tests in severity and prognosis of acute pancreatitis in pregnancy
Authors: Wang Yu , Qu Guangbo , Wu Zhangbi , Tian Dongmei , Yang Wenbei , Li Hongye , Lu Yu , Meng GuangJun , Zhang Hong
Published: April 2023

Background:

Currently, no guidelines specifically recommend scoring systems and biomarkers for early evaluation of the severity and prognosis of acute pancreatitis in pregnancy (APIP).

Objectives:

This study aimed to explore the early predictive value of scoring systems and routine laboratory tests on APIP severity and maternofetal prognosis.

Design:

This study retrospectively analyzed 62 APIP cases in a 6-year period.

Methods:

The predictive value of scoring systems and routine laboratory tests that were collected 24 h and 48 h after admission, for APIP severity and fetal loss, were analyzed.

Results:

To detect severe acute pancreatitis (SAP), a 24-h Bedside Index for severity in acute pancreatitis (BISAP) achieved a higher area under the curve (AUC) value of 0.910 than the Acute Physiology and Chronic Health Evaluation II (AUC = 0.898) and Ranson score (AUC = 0.880). The combination of BISAP, glucose, neutrophil-to-lymphocyte ratio (NLR), hematocrit (Hct), and serum creatinine (Scr) provided an AUC value of 0.984, which had greater predictive power than BISAP ( p = 0.015). 24-h BISAP and Hct were independent risk factors for predicting SAP of APIP. The cutoff values of Hct and blood urea nitrogen (BUN) to predict SAP were 35.60% and 3.75 mmol/l in the APIP. Furthermore, 24-h BISAP had the highest predictive power (AUC = 0.958) for fetal loss.

Conclusion:

BISAP is a convenient and reliable indicator for the early prediction of SAP and fetal loss in APIP. The combination of BISAP, glucose, NLR, Hct and Scr proved to be the optimal early markers for the prediction of SAP in APIP within 24 h after admission. In addition, Hct > 35.60% and BUN > 3.75 mmol/l may be suitable thresholds for predicting SAP in APIP.
Development and validation of prognostic nomograms for large hepatocellular carcinoma after HAIC
Authors: Yao Wang , Wei Ran , Jia Jia , Li Wang , Zuo Mengxuan , Zhuo Shuqing , Shi Ge , Wu Peihong , An Chao
Published: April 2023

Background and aims:

Hepatic arterial infusion chemotherapy (HAIC) using the FOLFOX regimen (oxaliplatin plus fluorouracil and leucovorin) is a promising option for large hepatocellular carcinoma (HCC). However, post-HAIC prognosis can vary in different patients due to tumor heterogeneity. Herein, we established two nomogram models to assess the survival prognosis of patients after HAIC combination therapy.

Methods:

A total of 1082 HCC patients who underwent initial HAIC were enrolled between February 2014 and December 2021. We built two nomogram models for survival prediction: the preoperative nomogram (pre-HAICN) using preoperative clinical data and the postoperative nomogram (post-HAICN) based on pre-HAICN and combination therapy. The two nomogram models were internally validated in one hospital and externally validated in four hospitals. A multivariate Cox proportional hazards model was used to identify risk factors for overall survival (OS). The performance outcomes of all models were compared by area under the receiver operating characteristic curve (AUC) analysis with the DeLong test.

Results:

Multivariable analysis identified larger tumor size, vascular invasion, metastasis, high albumin–bilirubin grade, and high alpha-fetoprotein as indicators for poor prognosis. With these variables, the pre-HAICN provided three risk strata for OS in the training cohort: low risk (5-year OS, 44.9%), middle risk (5-year OS, 20.6%), and high risk (5-year OS, 4.9%). The discrimination of the three strata was improved significantly in the post-HAICN, which included the above-mentioned factors and number of sessions, combination with immune checkpoint inhibitors, tyrosine kinase inhibitors, and local therapy (AUC, 0.802 versus 0.811, p < 0.001).

Conclusions:

The nomogram models are essential to identify patients with large HCC suitable for treatment with HAIC combination therapy and may potentially benefit personalized decision-making.

Lay summary

Hepatic arterial infusion chemotherapy (HAIC) provides sustained higher concentrations of chemotherapy agents in large hepatocellular carcinoma (HCC) by hepatic intra-arterial, result in better objective response outperformed the intravenous administration. HAIC is significantly correlated with favorable survival outcome and obtains extensive support in the effective and safe treatment of intermediate advanced-stage HCC. In view of the high heterogeneity of HCC, there is no consensus regarding the optimal tool for risk stratification before HAIC alone or HAIC combined with tyrosine kinase inhibitors or immune checkpoint inhibitors treatment in HCC. In this large collaboration, we established two nomogram models to estimate the prognosis and evaluate the survival benefits with different HAIC combination therapy. It could help physicians in decision-making before HAIC and comprehensive treatment for large HCC patients in clinical practice and future trials.
Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review
Authors: Lauricella Eleonora , Manicone Anna , Cavallo Federica , Dagrada Gian Paolo , Centonze Giovanni , Bertulli Rossella , Quattrone Pasquale , Porta Camillo , Cives Mauro
Published: April 2023

Adamantinoma-like Ewing sarcoma (ALES) of the salivary glands is an exceedingly rare malignancy defined by the t(11,22) EWSR1::FLI1 fusion, with complex epithelial differentiation. To identify features that can allow for better recognition of this disease entity, we reviewed all published reports of molecularly confirmed ALES of the salivary glands and explored epidemiological, clinical, radiological, pathological, and therapeutic characteristics of a population of 21 patients including a single newly reported patient from our group. We searched the English-language literature indexed in PubMed, Medline, Scopus, and Web of Science using the keyword ‘Adamantinoma-like Ewing sarcoma’ published up to June 2022. The median age at diagnosis was 46 years, and a slight female sex predilection was observed. Most tumors originated in the parotid gland (86%) and presented as a painless palpable mass with a median diameter of 3.6 cm. Metastatic dissemination was reported only in one patient (5%), and after a median follow-up of 13 months the 1-year overall survival rate was 92%. Salivary gland ALES were frequently misdiagnosed at presentation (62% of cases) and were pathologically characterized by the presence of highly monomorphic small round blue cells with infiltrative pattern and positive immunostaining for CD99 and high- and low-molecular weight cytokeratins. Epidemiological and clinical features of salivary gland ALES raise questions on the incorporation of this malignancy in the Ewing sarcoma family tumor group.
Growth mindset of meaning in Life: Viewing meaning in life as malleable matters
Authors: Huang Zhen , Wu Yiwen , Zhao Yukun , Peng Kaiping
Published: April 2023

Meaning in life contributes to psychological well-being. However, few studies have adopted an implicit theory approach to studying people's beliefs about the malleability of meaning in life. We propose the growth mindset of meaning in life (GMML) as the belief that meaning in life can be developed. In Study 1, we construct the Mindset of Meaning in Life Scale (MMLS) to measure GMML and demonstrate that GMML is distinct from growth mindset of intelligence and meaning in life. As predicted, GMML is positively associated with psychological well-being indicators, including life satisfaction and positive coping styles, and negatively correlated with ill-being measures such as depression and anxiety. In Study 2, tolerance of uncertainty was found to partially mediate the relationships between GMML and depression, anxiety, purpose in life, the presence of and search for meaning in life. Taken together, our findings suggest that GMML is a distinct construct relevant to individuals’ well-being and meaning in life.
Does evaluating oneself cause evaluations of others while observing a social interaction? An experimental investigation of the cognitive and emotional consequences following a false-feedback task
Authors: Ferguson Ryan J , Ouimet Allison J
Published: April 2023

Introduction

Despite decades of research on how people with social anxiety evaluate themselves and others, it remains unclear whether people who evaluate themselves negatively also evaluate others negatively. Findings from other-evaluation research are equivocal, perhaps attributable to methodology differences and inconsistent operationalization. Social-cognitive and cognitive-behavioural models suggest that negative self-evaluations may cause participants to subsequently evaluate a visibly anxious person negatively. We tested this hypothesis experimentally, using a video-recorded social interaction and novel false-feedback manipulation.

Methods: 169 unselected participants completed baseline questionnaires and a 10-min impromptu conversation task with a confederate. We randomly assigned participants to receive positive, ambiguous, or negative false-feedback about their performance. Next, they evaluated their own performance and watched a recorded conversation between an anxious and confident speaker. Finally, they evaluated the anxious person’s performance.

Results: Our manipulation was effective; participants in the negative-feedback condition rated themselves more negatively. However, no differences emerged between conditions on most cognitive and emotional outcomes.

Discussion: Evaluating oneself negatively, on its own, may not lead people to evaluate a visibly anxious person in a recorded social interaction negatively in a single-session experiment within an unselected sample. Future studies should examine this relationship with a clinical sample across time and contexts.
PrEP policy implementation gaps and opportunities in Latin America and the Caribbean: a scoping review
Authors: Murphy Luke , Bowra Andrea , Adams Ellithia , Cabello Robinson , Clark Jesse L. , Konda Kelika , Perez-Brumer Amaya
Published: April 2023

Background:

Pre-exposure prophylaxis (PrEP) is an important tool for HIV prevention in Latin America and the Caribbean (LAC). Yet, little is known about the PrEP policies landscape in the region. Addressing this gap, this scoping review assessed current PrEP policies throughout LAC to better understand existing PrEP implementation gaps and identify opportunities to improve access.

Methods:

We conducted a scoping review, using a modified PRISMA extension, through 28 July 2022, to identify country-level PrEP policies. Data were collected in English, Spanish, French, and Portuguese utilizing online platforms for screening and data extraction (Google Forms, Zotero, and Excel). Extracted data were divided by data source, including country-level government policies, gray literature, and peer-reviewed literature, with at least one full-text reviewer and data extractor per publication. An iterative summative content analysis was performed to compare and interpret themes across phases and data sources.

Results:

Of the 33 countries in LAC, 22 (67%) had policies approving daily oral PrEP for HIV prevention, which outlined specific key populations, including men who have sex with men, transgender women, sex workers, and serodiscordant couples. Generic tenofovir disoproxil fumarate/emtricitabine has been approved in 15 of the 33 countries, and 13 of the 33 countries have incorporated PrEP into their public health system. No countries were found to have approved cabotegravir. Costing data were reported by only one country, Ecuador, in its national health ministry guidelines. Findings also document a lag between the media/gray-literature announcement of PrEP and implementation of policies.

Conclusion:

Findings underscore significant advances in PrEP policies in the region and signal opportunities for greater PrEP implementation. Since 2017, an increasing number of countries have begun to provide PrEP to communities at heightened need, although significant gaps remain. Policy approval is a key step to further increasing access to PrEP in LAC, necessary to reduce the burden of HIV in LAC, specifically among marginalized populations.
Skin Staining Following Intravenous Iron Extravasation in a Patient With Chronic Kidney Disease: A Case Report
Authors: Shi Ruolin , Marin Judith G. , Beaulieu Monica
Published: April 2023

Rationale:

Intravenous iron is commonly use in anemia related to chronic kidney disease. Skin staining due to iron extravasation is a rare adverse reaction that can leave a long-term staining of the skin.

Presenting Concerns of the Patients:

During iron derisomaltose infusion, patient reported iron extravasation. Five months after the incident, the skin stain related to the extravasation was still present.

Diagnosis:

A case of skin staining due to iron derisomaltose extravasation was diagnosed.

Interventions/Outcomes:

She was reviewed by dermatology and laser therapy was offered.

Teaching Points:

Patients and clinicians need to be aware of this complication, and protocol needs to be put in place to minimize extravasation and its complication.
Amyloidoses in Onco-Nephrology Practice: A Multidisciplinary Case-Based Conference Report
Authors: Kitchlu Abhijat , Chan Christopher T. , Jhaveri Kenar D. , Delgado Diego , Tam Paul
Published: April 2023

Introduction and Objective:

Amyloidoses are a heterogeneous group of disorders resulting from deposition of amyloid fibrils into extracellular tissues. While the kidneys are one of the most frequent sites of amyloid deposition, amyloid deposits can also affect a wide range of organ systems, including the heart, liver, gastrointestinal tract, and peripheral nerves. The prognosis of amyloidosis, especially with cardiac involvement, remains poor; however, a collaborative approach applying new tools for diagnosis and management may improve outcomes. In September 2021, the Canadian Onco-Nephrology Interest Group hosted a symposium to discuss diagnostic challenges and recent advances in the management of amyloidosis from the perspectives of the nephrologist, cardiologist, and onco-hematologist.

Methods and Sources of Information:

Through structured presentations, the group discussed a series of cases highlighting the varied clinical presentations of amyloidoses affecting the kidney and heart. Expert opinions, clinical trial findings, and publication summaries were used to illustrate patient-related and treatment-related considerations in the diagnosis and management of amyloidoses.

Key findings:

(1) Overview of the clinical presentation of amyloidoses and the role of specialists in performing timely and accurate diagnostic workup; (2) review of best practices for multidisciplinary management of amyloidosis, including prognostic variables and determinants of treatment response; and (3) update on new and emerging treatments in the management of light chain and amyloid transthyretin amyloidoses.

Limitations:

This conference featured multidisciplinary discussion of cases, and learning points reflect the assessments by the involved experts/authors.

Implications:

Identification and management of amyloidoses can be facilitated with a multidisciplinary approach and higher index of suspicion from cardiologists, nephrologists, and hemato-oncologists. Increased awareness of clinical presentations and diagnostic algorithms for amyloidosis subtyping will lead to more timely interventions and improved clinical outcomes.
An integrated targeted metabolomics and network pharmacology approach to exploring the mechanism of ellagic acid against sleep deprivation-induced memory impairment and anxiety
Authors: Wang Wenjun , Liu Tianlong , Zhang Yi
Published: April 2023

Background

As a neuroprotective agent, ellagic acid (EA) is extremely beneficial. Our previous study found that EA can alleviate sleep deprivation (SD)-induced abnormal behaviors, although the mechanisms underlying this protective effect have not yet been fully elucidated.

Objective

An integrated network pharmacology and targeted metabolomics approach was utilized in this study to investigate the mechanism of EA against SD-induced memory impairment and anxiety.

Methods

Behavioral tests were conducted on mice after 72 h of SD. Hematoxylin and eosin staining and nissl staining were then carried out. Integration of network pharmacology and targeted metabolomics was performed. Eventually, the putative targets were further verified using molecular docking analyses and immunoblotting assays.

Results

The present study findings confirmed that EA ameliorated the behavioral abnormalities induced by SD and prevented histopathological and morphological damage to hippocampal neurons. Through multivariate analysis, clear clustering was obtained among different groups, and potential biomarkers were identified. Four key targets, catechol- O-methyltransferase (COMT), cytochrome P450 1B1 (CYP1B1), glutathione S-transferase A2 (GSTA2), and glutathione S-transferase P1 (GSTP1), as well as the related potential metabolites and metabolic pathways, were determined by further integrated analysis. Meanwhile, in-silico studies revealed that EA is well located inside the binding site of CYP1B1 and COMT. The experimental results further demonstrated that EA significantly reduced the increased expression of CYP1B1 and COMT caused by SD.

Conclusion

The findings of this study extended our understanding of the underlying mechanisms by which EA treats SD-induced memory impairment and anxiety, and suggested a novel approach to address the increased health risks associated with sleep loss.
Severity and worsening of fatigue among individuals with multiple sclerosis
Authors: Salter Amber , Keenan Alexander , Le Hoa H , Gandhi Kavita , Ait-Tihyaty Maria , Lancia Samantha , Cutter Gary R , Fox Robert J , Marrie Ruth Ann
Published: April 2023

Background

Fatigue is associated with reduced quality of life and social participation, and poor employment outcomes. However, most studies examining fatigue are limited by small sample sizes or short follow-up periods.

Objective

To characterize the natural history of fatigue.

Methods

The North American Research Committee on Multiple Sclerosis Registry participants with ≥7 years of longitudinal data between 2004 and 2019 and a relapsing disease course were included. A subset of participants enrolled within 5 years of diagnosis was identified. The Fatigue Performance Scale assessed fatigue and ≥1-point increase in Fatigue Performance Scale sustained at the next survey defined fatigue worsening.

Results

Of 3057 participants with longitudinal data, 944 were within 5 years of multiple sclerosis diagnosis. Most participants (52%) reported fatigue worsening during follow-up. Median time to fatigue worsening ranged from 3.5 to 5 years at lower levels of index fatigue. Fatigue worsening was associated with lower annual income, increasing disability, lower initial fatigue level, taking injectable disease-modifying therapies and increasing depression levels in the relapsing multiple sclerosis participants.

Conclusion

Most multiple sclerosis participants early in their disease suffer from fatigue and at least half reported fatigue worsening over time. Understanding factors associated with fatigue may help to identify populations most at risk of fatigue worsening will be informative for the overall management of patients with multiple sclerosis.
Local–Digital Activism: Place, Social Media, Body, and Violence in Changing Urban Politics
Authors: Zur Hadas , Hatuka Tali
Published: April 2023

Recent studies demonstrate how violence, social media, and protest intertwine. This article complements this body of knowledge and indicates how social media enables new modes of small-scale protest events and how it is being used by right-wing and middle-class groups to influence urban politics. The article conceptualizes local-digital activism as a particular form of protest that is based on a hybrid framework of action that entangles physical actions in public space with virtual acts of dissent, creating embodied digital activism in specific locales. The key arguments are threefold: (1) local–digital activism initiates a particular framework of action that is embedded in digital culture and can be used by different ideological groups. (2) The approach to place in this type of dissent is central and manifold, with physical and virtual spaces codefining one another. (3) Triggering violent encounters and using violent representations in place is strategic and intentional, a means to expand visibility on digital platforms. Empirically the article analyses two groups in South Tel Aviv, presenting their protest strategies and tactical use of place, digitization, violence, and the body in creating the iconography of the “other in the place.” The study is based on geographic and ethnographic work, in-depth interviews ( N = 24) with various actors, and social media content analysis (videos = 72, posts = 210). The final discussion addresses the characteristics of local-digital activism and its role in urban political struggles and offers paths for future research.
Surveillance infrastructure in China: Key concepts and mechanisms enhancing the Party-state’s governance ambitions
Authors: Trevaskes Susan , Bernot Ausma
Published: April 2023

Surveillance infrastructure in China monitors and enables authorities to react to potential risky, miscreant or criminal behaviour. What type of behaviours are perceived to be so, is determined in large part by ideology. Therefore, surveillance infrastructure relies on the machinery of ideology to define the boundaries of its use. In this paper, we outline six key ideological concepts relating to governance in Xi Jinping’s China that have helped to expand the boundaries of surveillance. We identify terms embedded in promotional material of Hikvision and other surveillance technology firms as a springboard for conceptual discussion. The aim is to survey the ideological lexicon of concepts that position surveillance within the Party-state’s broad capacity-building ambitions for governance in Xi’s China. This positioning amplifies the political responsibility of state, social and market actors to work together to broaden surveillance activities for ‘society-building’ purposes, and ultimately for the realisation of Xi Jinping’s goal of National Rejuvenation.
Helicopter Parenting Among Socio-Economically and Ethnically/Racially Diverse Emerging Adults: Associations with Weight-Related Behaviors
Authors: Arlinghaus Katherine R. , Hahn Samantha L. , Larson Nicole , Eisenberg Marla E. , Berge Jerica M. , Neumark-Sztainer Dianne
Published: April 2023

Helicopter parenting, a parenting style defined by over-involvement, may lead to poor health outcomes. However, research has primarily focused on children and adolescents from White, high socio-economic families, with little research examining weight-related health or with emerging adult children. The current study examined associations with emerging adult diet, physical activity, and body mass index (BMI) among a diverse population-based sample of parent and emerging adult dyads ( n = 919). Helicopter parenting was highest among lower socioeconomic households and those identifying as Black, Indigenous, or people of color. Helicopter parenting was associated with both healthy and less healthy dietary behaviors across ethnic/racial groups, but was not associated with physical activity or BMI. Greater consideration of the cultural context related to helicopter parenting is needed before making conclusions about its benefits or harms.
Response to Letter Regarding “Predictive Value of Preoperative Serum Albumin in Patients With Metastatic Spine Diseases: A Statistical Comment”
Authors: Cruz-Garza Jesus G. , Hirase Takashi , Bhenderu Lokeshwar S. , Taghlabi Khaled M. , Faraji Amir H. , Marco Rex A. W. , Saifi Comron
Published: April 2023

We thank the authors for their interest in and commentary on “Preoperative Serum Albumin Level Predicts Length of Stay and Perioperative Adverse Events Following Vertebral Corpectomy and Posterior Stabilization for Metastatic Spine Disease.” We appreciate the opportunity to respond to their comments herein.
Stock Market Reaction to COVID-19: A Cross-Sectional Industry Analysis in Frontier Market
Authors: Adnan ATM , Johani Sameer Al
Published: April 2023

The effect of COVID-19 on the efficiency of frontier stock markets at the industrial level has received little attention. This study aimed to analyze the Dhaka stock exchange’s immediate market response to the initial COVID-19 announcement at the industry level. An event study approach was used to cross-sectional daily returns of 311 enterprises grouped into seventeen industry groups to determine anomalous returns for a total of 21 trading days divided into seven separate event periods. According to the findings, the average abnormal return and cumulative average abnormal return for the total market return for the event and the subsequent days were both negative and statistically significant. A cross- sectional industrial analysis found that, except for the paper and printing industries, all other sectors produced a considerably abnormal and uniform negative abnormal return. The most substantial negative cumulative average abnormal returns were seen in event windows (0, 0), (0, +1) and (0, +5), which might be attributed to post-announcement drift and inefficient market activity. Furthermore, when comparing the results of the Manufacturing and Non-Manufacturing sectors, the Manufacturing sector had more gloomy outcomes. The COVID-19 epidemic was proven to have negative effects on several industry groups, including those in the pharmaceutical, information technology and telecommunications sectors, which were expected to benefit from the outbreak. This is one of the few empirical studies that investigate the impact of the epidemic on the cross-sectional industry stock return in frontier markets. The results of this research will aid both international and domestic investors in their pursuit of the best possible portfolio composition.
The Divergence Effects of Knowledge Transfer in the Family Business: Evidence from Nanchang
Authors: Huang Fei-Ming , Cvetkoska Violeta , Kassi Diby Francois , Gnahe Franck Edouard
Published: April 2023

Because it affects the next generation, knowledge transfer is a crucial resource for succession in a family-owned business. This paper examines how knowledge transfer impacts family businesses in Nanchang, Jiangxi Province, China. Data collection is done via semi-structured interviews, and data manipulation is done using data categorization and contextualization techniques. The findings show that: (i) the effect of knowledge transfers through the founder and beyond the family business results in a large amount of tacit knowledge in family businesses, whereas explicit knowledge is less significant, (ii) the most common means of knowledge transfer is that the successor uses the founder’s knowledge to innovate within the family business and (iii) the working atmosphere allows for ideas and knowledge to be shared, which is linked to the culture of family businesses. The paper also showed that family members prioritize their well-being and the well-being of their employees more than profit maximization in family businesses. Instead of seeking a one-sided knowledge transfer fit, the next generation should create novel insights and knowledge that are pertinent to the already-existing knowledge-based business.
Short-term Weight Trajectory of Severely Obese Individuals With and Without Pathogenic Satiety-Regulation Melanocortin 3/4 Receptor (MC3/4R) Mutations From a Multi-ethnic Asian Large Bariatric Surgery Program
Authors: Lim Joel Guanyi , Moh Angela , Pandian Bhuvaneswari , Ubeynarayana Chalani Udhyami , Lim Nathaniel Guanning , Tan Bo Chuan , Ng Deborah , Subramaniam Tavintharan , Cheng Anton , Lim Su Chi
Published: April 2023

The melanocortin (3 or 4) receptor (MC3/4R) is involved in regulating satiety and body weight. Therefore, pathogenic mutation in MC3/4R is associated with severe obesity, for which bariatric surgery is one of the treatment options. However, there is limited data on whether individuals with MC3/4R mutation will have differential weight response to surgery, especially among the Asian populations—the epi-center of the evolving global obesity epidemic. From our large prospective Obesity—Metabolism & Intervention Cohort Study (OMICS; N = 654, recruited between 2007 and 2022), 5 individuals with pathogenic MC3/4R mutations (“case”) were identified using candidate-genes panel next-generation sequencing (Illumina iSeq). These subjects were carefully propensity score–matched (baseline body mass index [BMI], age, sex, ethnicity, proportion with diabetes, type of bariatric surgery) in a 1:4 ratio to other controls. We performed linear mixed model analysis (for repeated measurements) to compare their longitudinal weight trajectories (percentage total weight loss, %TWL) over 12 months. The 5 cases with MC3/4R mutations were 48 ± 11 years, BMI 40.8 ± 11.2 kg/m2, 60% with diabetes, and all males. Their weight at baseline (pre-op), and 6 months and 12 months after surgery were 120 ± 38, 100 ± 31, and 101 ± 30 kg, respectively. Compared with propensity score–matched controls (N = 20), linear mixed model analysis suggested no difference in surgically induced %TWL (β coefficient = −5.8 ± 3.7, P = .13) over 12 months between the groups. Therefore, we conclude that rare pathogenic MC3/4R mutations do not significantly modify weight change (%TWL) in response to bariatric surgery.
Concurrent Displacements: Return, Waiting for Asylum, and Internal Displacement in Northern Mexico
Authors: Gil-Everaert Isabel , Masferrer Claudia , Chávez Oscar Rodríguez
Published: April 2023

This paper explores the ways in which contemporary mobility dynamics in Mexico have changed over the last decade, leading to protracted displacement. It focuses on three populations: (1) the internally displaced due to violence; (2) Mexican nationals returning from the United States, both voluntarily and due to deportation; and (3) populations seeking asylum in Mexico and the United States. These three populations are not usually analyzed together and do not squarely fall under the traditional legal definitions. The paper outlines ways that situations of protracted displacement and insecurity present challenges in four interconnected arenas of life: housing, legal status, employment, and emotional well-being. For governments and local communities, protracted displacement requires immediate humanitarian responses and the development and implementation of public policies focused on integration. The paper concludes with a set of policy recommendations based on its findings.
The Tampa, Afghan Refugees and New Zealand: A Commentary on the Duty to Protect and Refugee Integration
Authors: Pio ONZM Edwina , Ewazi Sakina
Published: April 2023

New Zealand has a long history of receiving persons in search of safety and security. These populations span Danes fleeing suppression during the German occupation in the 1870s, Jews escaping persecution from Tsarist Russia in the 1880s, Polish orphans during World War II, Asians expelled from Uganda in 1972–73, Vietnamese boat people between 1997 and 1993, and refugees from Afghanistan starting in 2001. New Zealand’s formal refugee resettlement program dates from 1944 with the arrival of the Polish orphans and their caregivers. This commentary discusses a case that builds on this history — New Zealand’s reception of Afghan refugees who were rescued by the MV Tampa, a Norwegian container ship. The authors — a researcher and a refugee saved by MV Tampa — explore New Zealand’s reception of refugees in light of the “Kew Garden” ethical principles on the responsibility to assist imperiled persons.
The Responses of Pakistan and Turkey to Refugee Influxes: A Comparative Analysis of Durable Solutions to Protracted Displacements
Authors: Siddikoglu Hidayet , Sagiroglu Ali Zafer
Published: April 2023

This research aims to study how Turkey and Pakistan (the world’s largest refugee hosting countries) have reacted to and managed protracted refugee challenges. In the context of Pakistan, the study explores the Afghan refugee influx since the late 1970, while for Turkey the focus is on the Syrian refugee inflow since 2011. While cognizant of contextual differences (time and space) between these two countries, we aim to comparatively explore policies, best practices, and short and long-term solutions developed to protracted displacement issues in each country. To do this we intend to comparatively explore the role of institutional environments and the international refugee regime in resolving protracted refugee issues in a chronological sequence. First, we investigate how each state’s “open-door policies” toward the first influx of refugees evolved into ad-hoc solutions in the course of protracted displacement.

Second, we comparatively assess multilevel integration approaches and solution strategies at the macro (states and their cooperation with countries of origin and inter-governmental organizations such as the UN High Commissioner for Refugees (UNHCR) and International Organization for Migration (IOM)), meso (interventions/implementations), and micro levels (civil society and refugee-led initiatives). Third, we examine how refugee policies in each country are negotiated with national and international humanitarian and refugee agencies, including regional organizations and countries of origin. Theoretically, this article is grounded on a macro structural approach (state’s international humanitarian obligations and responsibilities), refugee diplomacy (state’s use of diplomatic tools, process administering refugees), and management theories.
Working Conditions Among Chinese Nurses Employed in Japan: A Cross-Sectional Survey-Based Study
Authors: Yang Yuchun , Hatanaka Kaori , Takahashi Kei , Shimizu Yasuko
Published: April 2023

Introduction

Although the number of Chinese nurses employed in Japan is increasing, the situation regarding their work conditions has not been clarified. It is necessary to understand such conditions to consider support for Chinese nurses in Japan.

Objective

This study examined the professional nursing practice environment, occupational career, and work engagement of Chinese nurses in Japan.

Methods

Using a cross-sectional study design, 640 paper questionnaires were mailed to 58 Japanese hospitals that employed Chinese nurses and included a QR code for online responses. A survey request form and URL were sent to the Wechat app, where Chinese nurses in Japan communicate. The contents include attribute-related questions, the Practice Environment Scale of the Nursing Work Index (PES-NWI), Occupational Career Scale, and Utrecht Work Engagement Scale. Either Wilcoxon's rank-sum or the Kruskal–Wallis test was performed to compare scores of the study variables between subgroups.

Results

A total of 199 valid responses were obtained, of which 92.5% were female, and 69.3% had a university degree or higher. The PES-NWI score was 2.74, and the work engagement score was 3.10. The group with a university degree or higher had significantly lower scores on PES-NWI and work engagement than those with diplomas. Regarding the subscale of occupational career, scores of forming and coordinating interpersonal relationships, self-development, and accumulating a variety of experience were 3.80, 2.58, and 2.71, respectively. The scores were significantly higher with more than 6 years of nursing experience in Japan than those with 0–3 years or 3–6 years.

Conclusion

Most participants had university degrees or higher, and their scores of PES-NWI and work engagement tended to be lower than those with diploma degrees. Participants showed low self-ratings in self-development and lacked a variety of experience. Understanding Chinese nurses’ work conditions in Japan enables hospital administrators to develop measures for continuing education and support.
Factors Associated With Poor Patient-Reported Outcomes in Isolated Gastrocnemius Recession for Heel Pain
Authors: Sanchez Thomas , Sankey Turner , Donley Connor , Schick Sam , Underwood Meghan , Brannigan Matthew , Singh Swapnil , Shah Ashish
Published: April 2023

Background:

Gastrocnemius recession is commonly performed for a variety of pathologies of the foot and ankle, yet studies characterizing risk factors associated with patient-reported outcomes are limited. In this cohort study, patient outcomes were compared against the general population for PROMIS scores with correlation analysis comparing demographics and comorbidities. Our primary goal in this study is to identify risk factors associated with poor patient-reported outcomes following isolated gastrocnemius recession for patients with plantar fasciitis or insertional Achilles tendinopathy.

Methods:

A total of 189 patients met inclusion criteria. The open Strayer method was preferred. However, if the myotendinous junction could not be adequately visualized without expanding the excision, then a Baumann procedure was performed. The decision between the two did not depend on preoperative contracture. Patient demographics and visual analog scale (VAS) scores were obtained via the electronic medical record. Telephone interviews were completed to collect postoperative Patient-Reported Outcomes Measurement Information System (PROMIS) and Foot Function Index (FFI) scores. The data were analyzed using the type 3 SS analysis of variance test to identify individual patient factors associated with reduced PROMIS, FFI, and VAS scores.

Results:

No demographic variables were found to be significantly associated with postoperative complications. Patients who reported tobacco use at the time of surgery had significantly decreased postoperative PROMIS physical function ( P = .01), PROMIS pain interference ( P < .05), total FFI scores ( P < .0001), and each individual FFI component score. Patients undergoing their first foot and ankle surgeries reported numerous significant postoperative outcomes, including decreased PROMIS pain interference ( P = .03), higher PROMIS depression ( P = .04), and lower FFI pain scores ( P = .04). Hypertension was significantly associated with an increased FFI disability score ( P = .03) and, along with body mass index (BMI) >30 ( P < .05) and peripheral neuropathy ( P = .03), significantly higher FFI activity limitation scores ( P = .01). Pre- and postoperative VAS scores demonstrated improvement in patient-reported pain from a mean of 5.53 to 2.11, respectively ( P < .001).

Conclusion:

We found in this cohort that numerous patient factors were independently associated with differences in patient-reported outcomes following a Strayer gastrocnemius recession performed for plantar fasciitis or insertional Achilles tendinopathy. These factors include, but are not limited to, tobacco use, prior foot and ankle surgeries, and BMI. This study strengthens previous reports demonstrating the efficacy of isolated gastrocnemius recession and elucidates variables that may affect patient-reported outcomes.

Level of Evidence:

Level III, retrospective cohort study.
Deviant accumulation at farmed animal sanctuaries
Authors: Rosenfeld Heather
Published: April 2023

In much of Western society, animals such as chickens are considered commodities. As such, they are bred and raised to produce eggs, meat, and entertainment. Farmed animal sanctuaries challenge this status quo by rescuing, rehabilitating, and caring for these animals. In so doing, sanctuaries implicitly and often explicitly challenge chickens’ and other farmed animals’ status as commodities. What does decommodification entail? How do we get from capitalist lively commodities to other interactions with living beings? Drawing on mixed methods ethnographic fieldwork, this paper theorizes the decommodification process, elaborating the more-than-capitalist political economy of chicken rescue and sanctuary. I make the case that the political economic work of sanctuaries begins, though occasionally tragically ends, with processes akin to hoarding. In turn, I suggest that we think of hoarding less stigmatically and more in terms of political economy, as deviant accumulation. Building on Marx's understanding of hoarding as a process of accumulating without exchanging, deviant accumulation is accumulation that challenges capitalocentric norms. As such, by taking animals out of a system of exchange value, all sanctuaries practice deviant accumulation. Deviant accumulation thus becomes a practice that is potentially radically anti-capitalist: a practice from which different and non-anthropocentric values can emerge. I explicate the concept of deviant accumulation, how sanctuaries practice it, and to what ends.
Procedural Estoppel in International Commercial Arbitration Proceedings
Authors: Bantekas Ilias
Published: April 2023

This article argues that arbitral practice has effectively given rise to a general principle whereby the parties to arbitral proceedings are deemed to have waived rights arising from a procedural rule where they have failed to timely raise an objection against a procedural irregularity. Tribunals do not refer to such a process as abuse of right, or procedural estoppel, but as a tacit waiver of procedural rights. Even so, the effects are the same. This rule is well enshrined in article 4 of the UNCITRAL Model Law on International Commercial Arbitration. There is a line of domestic case law suggesting that the presumption in favour of the waiver does not apply where the party in question had no knowledge of the facts giving rise to the breach; where failure to apply it was not predicated on bad faith and/or; where the delay in exercising the right was not significant.
Poverty and Relapse Risk in Children with Acute Lymphoblastic Leukemia: Children's Oncology Group Study AALL03N1 Report
Authors: Wadhwa Aman , Chen Yanjun , Hageman Lindsey , Hoppmann Anna , Angiolillo Anne , Dickens David , Neglia Joseph P , Ravindranath Yaddanapudi , Ritchey Kim , Termuhlen Amanda , Wong F. Lennie , Landier Wendy , Bhatia Smita
Published: April 2023

The association between individual-level poverty and relapse in children receiving maintenance treatment for acute lymphoblastic leukemia (ALL) remains unclear. In a secondary analysis of COG-AALL03N1, we used data from US Census Bureau to categorize patients living below year-specific federal poverty thresholds, calculated using self-reported annual household income and size of household. Participants living 120% below federal poverty thresholds were categorized as living in extreme poverty. Hazard of relapse was estimated using multivariable proportional subdistributional hazards regression for patients living in extreme poverty while receiving ALL maintenance therapy after adjusting for relevant predictors. Among 592 patients in this analysis, 12.3% of the patients were living in extreme poverty. After a median follow-up of 7.9y, the cumulative incidence of relapse at 3y from study enrollment among those living in extreme poverty was significantly higher (14.3%, 95% confidence interval [CI]= 7.3-23.6) compared to those not living in extreme poverty (7.6%, 95%CI=5.5-10.1, P=0.04). Multivariable analysis demonstrated that children living in extreme poverty had a 1.95-fold greater hazard of relapse (95%CI=1.03-3.72, P=0.04) compared to those not living in extreme poverty; this association was mitigated after inclusion of race/ethnicity in the model (hazard ratio=1.68, 95%CI=0.86-3.28, P=0.1), likely due to collinearity between race/ethnicity and poverty. A greater proportion of children living in extreme poverty were non-adherent to mercaptopurine (57.1% vs 40.9%, P=0.04); however, poor adherence did not completely explain the association between poverty and relapse risk. Future studies need to understand the mechanisms underlying the association between extreme poverty and relapse risk. Clinical Trial number: NCT00268528.