bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence Of The Personal And Social Responsibility Teaching Model (TPSR) And The Cooperative Model On Life Proficiency In Physical, Sport And Health Education
Authors: Muharam Haidzar Fauzan , Budiana Dian , Mahendra Agus
Published: October 2023

Life skills as skills needed to overcome the demands and demands of everyday life to see an increase in life skills in research students used two learning models, namely the Teaching Personal and Social Responsibility (TPSR) model and the cooperative model. The purpose of this study was to find out how much influence the Teaching Personal and Social Responsibility (TPSR) model and cooperative model had on life skills in physical education, sports and health. The research method in this study is to use a comparative experimental method, comparative research to find out whether two variables or more than two groups have differences in the aspects or variables studied. The experimental research design used in this study was the Pretest-Posttest Control Group Design. The samples used in this study were 15 students in the TPSR group and 15 students in the cooperative group. With the application of the TPSR learning model which aims to improve aspects of students' life skills, the average pretest score = 150.13 and the posttest average score = 166.40 with a difference in score of 16.27. As for the cooperative learning model which aims to improve aspects of students' life skills, the average pretest score = 112.27 and the posttest average score = 158.33 with a difference in score of 46.07. Thus, the difference in the average value of the TPSR learning model is smaller than the difference in the average value of the cooperative learning model, so that it can be concluded that the cooperative learning model has more influence on students' life skills.
The Influence Of Extracuricular Sports Programs On The Development Of Life Skills During The Covid-19 Pandemi At Ta'mirul Islam Elementary School
Authors: Wijayanti Prima Ayu Sukarsana , Pitriani Pipit , Mahendra Agus
Published: October 2023

The purpose of this research is to explore life skills that are developed through sports at the Ta'mirul Islam Elementary School in Surakarta. More in-depth research is needed to explore the role of developing life skills through sports extracurricular participation. Data was collected through the Life Skills Scale for Sport (LSSS) and supporting questionnaires using survey techniques. The research method used is descriptive-comparative causal (expose facto). The results showed (1) students who took part in sports extracurriculars obtained the highest life skills; (2) there are differences in the value of life skills between groups of students who take part in sports extracurriculars and groups of students who take part in non-sport extracurriculars; (3) there are differences in the values ​​of life skills between groups of students who take part in sports extracurriculars and groups of students who do not take part in any extracurriculars; (4) There are differences in the values ​​of life skills between groups of students who take part in non-sport extracurriculars and groups of students who do not take part in any extracurriculars. Conclusion sports extracurriculars can be used by schools as a means to transfer life skills to students in order to develop all the potential that exists in students to live their daily lives.
The Impact of Sports and Health Physical Education Learning on Body Mass Index and Physical Fitness Before and During the Covid-19 Pandemic at SMP Negeri 1 Losari Cirebon
Authors: Riyadi Ibnu , Rahayu Setya , Sumartiningsih Sri
Published: October 2023

This exercise aims to discover the Impact of Physical Education, Learning Sports, and Health on Body Mass Index and Physical Fitness Before and During the Covid 19 Pandemic at SMP Negeri 1 Losari Cirebon. Comparative research design with a research sample of 120 students. The sample in the study was taken by total sampling. The test instrument for measuring body mass index is measuring body weight with a kilogram scale and height with a meter in cm. Meanwhile, physical fitness is measured by the bleep test. The results of the study showed (1) There was an impact of learning sports and health physical education on body mass index before the covid 19 pandemic at SMP Negeri 1 Losari Cirebon (2) There was an impact of learning physical education sports and health on physical fitness before the covid 19 pandemic at SMP Negeri 1 Losari Cirebon.
Development Of Basic Locomotor Movement Games Based On Local Wisdom For Learning Pjok Class 1 Elementary Schools
Authors: Taroreh Bangkit Seandi , Satria M. Haris
Published: October 2023

The aims of this study were 1) to produce basic locomotor motion games based on local wisdom for Class 1 Elementary School PJOK learning, 2) to find out the effectiveness of their use in learning. This study used research and development (R and D) methods with the ADDIE approach. The research population was 1st grade elementary school students in Palembang City. The sampling technique used a purposive sample totaling 42 students with criteria including 1) being a tri dharma partner school of higher education with a Universitas Bina Darma in MBKM and PPL activities, 2) grade 1 elementary school students, 3) using the 2013 curriculum. The research instrument was a questionnaire. Data analysis techniques using quantitative analysis. The results of the research included: 1) learning media products in the form of basic locomotor games based on local wisdom for PJOK first grade elementary school learning, 2) the resulting learning media products showed the effectiveness of "very suitable for use" with a percentage of 83%
Integration Cluster and Path Analysis Based on Science Data in Revealing Stunting Incidents
Authors: Marchamah Mamlu’atul , Fernandes Adji Achmad Rinaldo , Solimun  , Wardhani Ni Wayan Surya , Putri Henida Ratna Ayu
Published: October 2023

The purpose of this research is to utilize big data to explore the factors that influence the prevalence of stunting in Wajak Regency, model these factors using integrated cluster analysis and` path analysis model, and develop an information system for stunting incidence modeling. This study uses a descriptive and explanative approach, namely using Discourse Network Analysis, cluster analysis, path analysis, and integration of cluster and path analysis. The sample of this research is children under five in Wajak District who were selected using stratified random sampling. The distance measure that has the highest model goodness value in modeling using the integration of cluster analysis with path analysis is the Mahalanobis distance measure. The cluster analysis with Mahalanobis distance produces 3 clusters where cluster one is a toddler who has a low stunting category, cluster two is a group of toddlers who has a moderate stunting category, and cluster three is a group of toddlers who has a high stunting category. The originality of this study is the application of Discourse Network Analysis analysis to obtain new variables followed by a comparison of three distances namely euclidean, manhattan, and mahalanobis in modeling using cluster integration and parametric paths.
Applied Different Pixel Selection in METRIC Model for Estimating Spatial Daily Evapotranspiration of Oil Palm in East Kalimantan Province, Indonesia
Authors: Dhohir Nur Muhammad Abdul , June Tania
Published: October 2023

Determination of evapotranspiration (ET) plays a key role in managing water in oil palm plantations. Several energy balances models have been developed for mapping evapotranspiration regionally. Subsequently, this study aims to estimate daily evapotranspiration in oil palm plantation using the METRIC model, where pixel selection used and corrected by hot and cold pixels. The climate data were collected from ERA-5 Reanalysis and Landsat 8 was used for spatial analysis. The result depicts the means ± standard deviation of ET without pixel selection (with pixel selection), specifically for oil palms age of 4, 6, 7, 8, 9, 11, 12 and 13 years were 3.19 ± 1.62 mm d-1, 3.31 ± 1.14 mm d-1, 4.01 ± 0.96 mm d-1, 4.84 ± 0.87 mm d-1, 6.29 ± 0.43 mm d-1, 5.72 ± 0.44 mm d-1, 6.43 ± 0.23 mm d-1 and 6.21 ± 0.33 mm d-1 (4.22 ± 0.49 mm d-1, 3.99 ± 0.22 mm d-1, 2.96 ± 0.34 mm d-1, 3.14 ± 0.33 mm d-1, 4.22 ± 0.49 mm d-1, 3.99 ± 0.22 mm d-1, 4.26 ± 0.24 mm d-1 and 4.18 ± 0.30 mm d-1), respectively. We have found more accurate ET determination with pixel selection (higher coefficient of determination).
Panel Data Regression Analysis for Economic Growth Rate In Bengkulu Province
Authors: Supianti Filo
Published: October 2023

Panel data is a combination of time series data and cross section data. The analytical method used for panel data is panel data regression. One of the advantages of analysis using panel data regress One of the indicators to measure the development of the production of goods and services in an economic area in a given year against the value of the previous year which is calculated based on GDP/GRDP at constant prices is Economic Growth. The dependent variable in this study is the growth rate of GRDP. The independent variable in this study is IPM, TPAK, TPT. This study uses panel data regression analysis with the Common Effect Model (CEM), Fixed Effect Model (FEM) and Random Effect Model (REM). The data processing in this study uses the R Studio application.
Implementation of Local Wisdom-Based Learning Management in Inclusive Schools
Authors: Famella Shelvie , Marsidin Sufyarma , Hadiyanto  , Gistituati Nurhizrah , Rifma
Published: October 2023

The research aims to identify how the management of inclusive school learning based on local wisdom is implemented in junior high schools. Our research is qualitative with an explanatory approach. The study participants were selected following a sampling technique with specific criteria. Data collection techniques include observations made by researchers without being directly involved in activities. In addition, interviews were conducted through direct communication between the interviewer and the participant. The data analysis technique was interactive, consisting of three activity lines including (1) data reduction, (2) data display, and (3) data verification. Theoretically, the teacher's research results show that implementing local wisdom-based learning management in inclusive schools has not been effective and needs to be improved in every aspect so that children with special needs can learn like other children.
Cultura starter em patê de pintado amazônico (Pseudoplatystoma fasciatum x Leiarius marmoratus): Desenvolvimento e determinação do prazo comercial
Authors: Porfírio Talitha Maria , Arruda Iara Oliveira , Alves Ariane Barbosa , Nascimento Edgar , Lanzarin Marilu , Ritter Daniel Oster
Published: October 2023

O presente estudo teve como objetivo elaborar um patê de pintado amazônico adicionado de cultura starter (Staphylococcus xylosus e Pediococcus pensosaceus), realizar sua caracterização e determinar o prazo comercial e desenvolver um modelo matemático preditivo para verificar a o crescimento da cultura.  O patê foi preparado com pescado cozido e cultura starter. Foram realizadas análises físico-químicas e microbiológicas do patê, que foram armazenados em embalagens de plástico e de vidro, durante 24 dias a 10°C. O patê apresentou conteúdos de umidade, cinzas, proteínas, lipídios e parâmetros de cor (próximo ao branco, vermelho e amarelo), estáveis durante estocagem e avaliação sanitária dentro dos padrões legais. O pH do produto diminuiu ao longo do tempo (de 6,43 para 5,11), enquanto as bases voláteis totais e a oxidação lipídica aumentaram (de 8,81 para 10,36 mgN/100g e de 0,35 para 0,52 MDA/Kg, respectivamente). As bactérias mesófilas aumentaram (de 6,66 para 9,25 log UFC/g), enquanto as bactérias psicrotróficas e Pseudomonas sp mostraram crescimento limitado (4,79 e 0 log UFC/g, respectivamente). As bactérias da cultura starter apresentaram um bom desenvolvimento (de 6,51 e 6,57 log UFC/g para 9,32 e 9,12 log UFC/g) e crescimento exponencial após uma curta fase de adaptação, conforme modelado pelo modelo de Gompertz. Baseando-se nesses resultados, o prazo comercial foi estabelecido em 15 dias, concluindo que desenvolver um patê de pescado adicionado de cultura starter proporcionará ao consumidor características atrativas.
Perfil epidemiológico da insuficiência renal no Brasil de 2012 a 2022
Authors: Duarte Ana Beatriz Araújo , Santos Sayron Natanael Lopes Pereira , Araújo Malanny Santos , Macário Edenia Soares de Figueirêdo , Farias Marco Antonio Galvão Martins de , Lima Maria Marta Prado , Oliveira Daniele Martins de Lima
Published: October 2023

Introdução: A insuficiência renal é caracterizada como queda da função renal. Essa doença pode ser classificada, de acordo com a evolução em Insuficiência Renal Aguda (IRA), quando há perda súbita, porém, reversível, ou em Insuficiência Renal Crônica (IRC) quando há perda progressiva. É uma importante causa de mortalidade, internações e que gera custos expressivos ao sistema de saúde. O objetivo deste trabalho é analisar as internações e perfil epidemiológico de insuficiência renal no Brasil entre 2012 e 2022. Metodologia: Trata-se de um estudo epidemiológico realizado no período de 2012 a 2022 tendo como embasamento os dados do departamento de informação de saúde do SUS (Sistema Único de Saúde). As variáveis utilizadas foram: internações hospitalares, óbitos, faixa etária, cor/raça, sexo, gastos hospitalares e macrorregião de saúde. Resultados: Obteve-se um total de 1185600 internações, dentre as quais 151053 evoluíram para óbito. As parcelas mais acometidas da população brasileira foram: homens (56,9%); raça branca (35,2%); idades entre 59-69 anos (41,3%). Ademais, foi demonstrado que a região mais acometida, tanto em questão de número de internações e óbitos como nos gastos hospitalares foi o Sudeste. Conclusão: A insuficiência renal é uma doença de grande relevância que causa prejuízos de ordem física, social e emocional. Nesse sentido, é importante a realização de ações preventivas em relação a esse quadro, visto que, suas principais etiologias estão relacionadas às circunstâncias modificáveis.
Prevenção da úlcera do pé diabético: Análise da atuação de profissionais da Atenção Básica em Saúde
Authors: Ferreira Ana Cláudia Barbosa Honório , Alvarenga Eliés Gomes dos Santos
Published: October 2023

O diabetes é uma doença metabólica crônica cujo número de pessoas com a doença vem aumentando consideravelmente nos últimos anos. Dentre as complicações, destaca-se a úlcera do pé diabético. Para a prevenção desta complicação são necessários cuidados diários com a saúde e os pés das pessoas com diabetes, para que a doença não se instale e traga prejuízos físicos e emocionais, como a formação de ulcerações e até amputação. A atuação dos profissionais de saúde, em especial médicos e enfermeiros que atuam na atenção básica em saúde, é fundamental no sentido de educar os pacientes quantos aos hábitos e atitudes corretas, avaliação e exame dos pés periodicamente. Objetivo: analisar quais são as ações realizadas pelos profissionais de saúde da atenção básica, médicos e enfermeiros, para a prevenção da úlcera do pé diabético. Metodologia: Para tanto, foram entrevistados médicos e enfermeiros que atuam na Equipe de Saúde da Família de um município de Minas Gerais. Resultados: observou-se que os profissionais não conhecem os equipamentos necessários ao exame dos pés, além de não adotarem protocolos de atendimento voltados a este público. Conclusão: Apesar de relatarem realizar as orientações necessárias a prevenção da úlcera do pé diabético, é importante repensar as condutas de atendimento voltadas a pessoa com diabetes, e na prevenção de complicações.
Avaliação do impacto das telas de dispositivos eletrônicos na qualidade do sono de crianças em tempos de pandemia pelo novo coronavírus em Aracaju - Sergipe
Authors: Barreto Natália Araújo , Oliveira Larissa Marrocos de , Reis Francisco Prado , Feitosa Juliana Santos , Figueiredo Thainá de Araujo Diniz , Santos Beatriz Villar Meneses , Moraes Ana Victoria Lima Boto
Published: October 2023

Introdução: O final do ano de 2019 e início de 2020 é marcado por um dos maiores desafios aos sistemas de saúde, do século XX. Após a instauração da pandemia pelo novo coronavírus, as crianças foram submetidas ao isolamento social. Sendo assim, no tocante ao estilo de vida de pré-escolares e escolares, um fator que chamou atenção foi a influência da intensificação da exposição de telas e sua possível influência na qualidade de sono. Objetivo: Objetivou-se avaliar o impacto das telas de dispositivos eletrônicos na qualidade sono das crianças em tempos de pandemia do COVID-19 na cidade de Aracaju. Métodos: Aplicados questionários via formulário eletrônico, após a coleta, foi realizado o cruzamento entre as variáveis categóricas de interesse com o tempo de tela das crianças em tempo de pandemia realizado em Aracaju, realizado por meio do teste de Qui-quadrado (c2). Resultados: Os dados encontrados demonstram que a exposição precoce e extensa frente às telas está associada ao sono insatisfatório, em relação à curta duração do sono, bem como na eficiência do mesmo. Conclusão: Com base nas informações obtidas, é possível concluir nesse estudo que a pandemia pela COVID-19 impactou de forma significativa a rotina das crianças, incluindo o abuso de telas de dispositivos eletrônicos na população infantil, que trazem inúmeros malefícios, incluindo a qualidade do sono.
Estresse hídrico na qualidade fisiológica de sementes de soja tratadas com tiametoxam e polímeros
Authors: Ludwig Eduardo José , Nunes Ubirajara Russi , Santos Cassiano Vasconcelos dos , Zini Priscila Barbieri , Kleinpaul Jessica Andiara , De Bastiani Géssica Gaboardi
Published: October 2023

O objetivo do presente trabalho foi avaliar as respostas fisiológicas em sementes de soja com distintos níveis de vigor tratadas com polímeros e tiametoxam submetidas a déficit hídrico simulado. Foram utilizados dois lotes de sementes de soja da cultivar Nidera NA5909, em que a diferenciação ocorreu pelo seu nível de vigor. Para realização do tratamento de sementes foi utilizado o produto comercial Cruizer 350FS, devido ao seu ingrediente ativo tiametoxam possuir a propriedade bioativadora e foram utilizados os polímeros Laborsan e Likoseed. A condição de estresse hídrico simulado foi realizada de duas formas, em rolos de papel germitest, a qual foi realizada utilizando soluções de polietileno glicol (PEG 6000) e em bandejas de PVC, contendo areia e diferentes níveis de saturação hídrica. A avaliação da qualidade fisiológica foi realizada por meio dos testes de germinação, primeira contagem de germinação, comprimento e massa seca de plântulas. Concluiu-se que para ambos os lotes tanto o estresse hídrico simulado em rolos de papel como em areia, houve redução do desempenho fisiológico das sementes e que a molécula tiametoxam associada ou não a polímeros proporcionou melhor desenvolvimento em plântulas de soja de baixo vigor quando submetidas a estresse hídrico.
Análise do perfil dos recém-nascidos com anóxia perinatal na Unidade de Terapia Intensiva Neonatal de uma maternidade privada em Sergipe
Authors: Matos Ana Caroline Gusmão de , Almeida Renata Carvalho , Andrade Thiago Vaz de , Pavione Marcos Alves
Published: October 2023

Objetivo: Avaliar o perfil dos neonatos com idade gestacional ≥ 35 semanas com anóxia perinatal na Unidade de Terapia Intensiva Neonatal (UTIN) de uma maternidade privada de Aracaju, Sergipe. Metodologia: Trata-se de um estudo clínico observacional, de caráter descritivo e transversal. Utilizou-se amostra de conveniência, composta por todos os recém-nascidos com  idade gestacional ≥ 35 semanas internados na UTIN de 01 janeiro de 2019 até 31 de dezembro de 2020. Foram excluídos os neonatos fora da idade gestacional do estudo e prontuários incompletos. O escore de Apgar menor que 7 no 5º minuto foi utilizado para definir anóxia neonatal (AN). A análise utilizou os testes Qui-Quadrado de Pearson, exato de Fisher, Shapiro-Wilk, Mann-Whitney e Kruskal-Wallis, além de dados descritivos. Aplicou-se nível de significância de 5%. Resultados: A amostra final foi de 127 crianças, majoritariamente do sexo masculino (63,7%), com peso normal ao nascer (75,2%) e peso adequado para idade gestacional (79,6%). O peso médio e idade gestacional média foram 2.982,7 gramas (± 649,5) e 37,5 semanas (± 1,6), respectivamente. Os grupos com e sem AN não apresentaram diferenças epidemiológicas significativas. Foi encontrado maior risco de anoxia em nascidos por via vaginal (p=0,001) e naqueles com eventos perinatais agudos (p=0,003). Tamanho pequeno para idade gestacional foi fator de risco para o desfecho óbito. Conclusão: Eventos perinatais agudos e parto vaginal são fatores de risco para AN. Recém-nascidos pequenos para idade gestacional apresentam piores desfechos. Futuros estudos discriminando os tipos de parto para análise de associação com AN podem ser úteis.
Türk Kalkışı
Authors: Orhan Özlem , Çetin Ebru , Yarım İmdat
Published: October 2023

Bu çalışmanın amacı, literatüre Türk Kalkışı (TK) olarak giren, kuvvet, mobilizasyon, stabilizasyon ve denge parametrelerini içeren fonksiyonel bir hareket olan TK’nin incelenmesidir. İlk olarak hareketin tekniği ve yapılış aşamaları ele alınmıştır. Sonrasında tarihi süreç içerisinde kullanım amaçları açıklanmıştır. Bunlarla birlikte günümüze kadar farklı alanlarda kullanılan TK’nin literatür ve araştırmalardaki yeri ve önemi değerlendirilmiştir. Araştırmada tarama yöntemi kullanılmıştır. Yapılan araştırma sonucunda yerli ve yabancı bilimsel veri tabanları taranmış; TK ile ilgili 9 uluslararası makale, 3 adet ulusal tez (lisans üstü) ve 1 adet kitap bölümüne ulaşılabilmiştir. Çalışmalar detaylı olarak incelenmiş; başlığı, yılı, yöntemi ve kapsamı sınıflandırılarak verilmiştir. Elde edilen sonuçlar farklı alanlarda kullanıma yönelik olarak değerlendirilerek açıklanmıştır.
Penguatan Edukasi Hukum Dampak Informasi Informasi Hoax di Media Sosial Era Masyarakat Industri 4.0
Authors: HIDAYATI PERMATA IKA
Published: October 2023

The rapid development of information and communication technology is directly proportional to the development of technology, especially the internet. These developments have more or less led to positive things, but of course there are negative impacts that come with it. The existence of the internet, coupled with the culture that has developed in the new public space, makes it difficult for people to differentiate between factual information and hoax information. The phenomenon of hoax information in Indonesia has caused divisions among the nation's children, both in the name of religion, ethnicity and class. Hoax information can literally be interpreted as a hoax, joke, deceptive plan, telling a false story, misleading publicity, or business fraud via print or electronic media. Based on this phenomenon, we feel the need to educate the public about the impact of spreading hoax information. Considering that the role of the Government is not strong enough to work alone, the community and various parties must participate in helping fight HOAX INFORMATION. The method that will be used in this community service is through outreach activities to strengthen legal education by discussing and providing exposure regarding the risks from the spread of hoax information which will be held at Pengajian Azzahra RW 7, Karang Besuki Village.
PENYULUHAN TENTANG KEBERSIHAN LINGKUNGAN WARGA MASYARAKAT TERHADAP MAHASISWA PPL IKIP BUDI UTOMO MALANG DALAM GOTONG ROYONG PEMBERSIHAN LINGKUNGAN DI AREA KANTOR DESA ANA GOKA.
Authors: Novariyanto Rizki Agung , Kondo Martina
Published: October 2023

Kegiatan Pmbp ini berfokus pada peran mahasiswa PPL dalam melaksanakan kegiatan gotong royong. Peran mahasiswa PPL ini dalam melaksanakan kegiatan gotong royong sangat memungkinkan dan mengingat apa yang menjadi kewenangannya, tentunya dapat membangun kesadaran masyarakat desa. Oleh karena itu perlu suatu strategi maupun kebijakan agar dalam pelaksanaanya dapat berjalan dengan baik. Kegiatan PMBP ini bertujuan untuk mendeskripsikan serta peran masyarakat dalam melaksanakan kegiatan gotong royong  di Desa Anagouka. Informan penelitian ini adalah kepala desa, Aparat desa, dan warga masyarakat di Desa Anagouka. Teknik pengumpulan data pada penelitian ini adalah observasi, gotong royong, dan dokumentasi. Hasil yang di dapatkan dalam penelitian ini menunjukkan beberapa hal pertama, melalui kegiatan gotong royong bersama aparat desa  dan masyarakat desa mali iha, kepedulian masyarakat terhadap mahasiswa ppl dalam membantu melaksanakan kegiatan pmbp, aparatur desa sebagai motivator  telah bekerjasama dalam hal ini bersama-sama meningkatkan pembangunan desa dengan pelaksanaan gotong royong, peran aparatur desa sebagai fasilitator cukup membantu masyarakat desa Ana goka, yang menyatakan bahwa kepala desa sangat membantu dalam memecahkan masalah pembangunan desa.
Treatment optimisation in chronic urticaria and angioedema
Authors:   , Alizadeh Aghdam Mehran
Published: October 2023

This thesis offers new insights into the pathogenesis and management of chronic urticaria (CU), including angioedema, and suggests possibilities for a more personalized treatment approach. Using drug-survival analysis, we found that omalizumab treatment in adults and children was mainly discontinued due to well-controlled disease. Ineffectiveness or side effects are rare reasons for discontinuation, demonstrating the high effectiveness and safety of omalizumab in the treatment of CU in daily practice. In patients with a good or complete response, omalizumab treatment intervals can be extended from the standard of 4 weeks to 7 weeks (median) or longer. In patients with an insufficient treatment response to omalizumab with the standard dose of 300 mg, an increase in the dose up to 600 mg led to a significant improvement in 61% of patients.
The exact pathomechanism of CU and the exact mechanism of action of omalizumab remain unknown. We found that FcεRI expression on basophils decreased significantly after omalizumab administration, while anti-IgE-induced degranulation increased significantly. Additionally, we demonstrated complement component C4d deposition in affected skin and elevated blood levels of C5a in CU patients. None of the findings regarding the complement system or FcεRI expression, however, could be related to omalizumab treatment response.
Angioedema might occur, with or without wheals, and is highly manageable in the majority of patients without prophylactic therapy or with antihistamine monotherapy. Fourteen percent required add-on treatment with omalizumab or other drugs. In patients with angioedema without wheals, recombinant human C1 esterase inhibitor treatment might be a treatment option when omalizumab has failed.
We are all on the same team
Authors:   , Langedijk Annefleur Christel
Published: October 2023

The harmonious dance between academia and industry

This is an exciting time for RSV research. With the recent approval of the first-ever RSV vaccines and monoclonal antibody (mAb) for all infants, we are on the cusp of major advances in the prevention of RSV disease. Of these RSV vaccines, many are a result of joint research between academia and industry. The rationale is that these PPPs overcome challenges in financing, implementation and delivery of infrastructure and public services, based on the assumption that the private sector brings additional finance and competence and that private companies are inherently more efficient than the public sector in delivering high-quality public services. While the concept of PPPs appears straightforward, the implementation may face multiple challenges. PPPs are complex as the value for money is often ethically questioned and the procurement processes can be lenghty because of legal and regulatory barriers. Lack of transparency and accountability may be the top barrier of PPPs, however, legal barriers including approval and permits and law and regulation changes may also slow down the process. With RSV prevention within reach and the potential risk of PPPs creating complex challenges, we have explored how PPPs co-create value in RSV research.

Is industry-funded RSV research on balance beneficial? Clearly it is. Ultimately, the positives of PPPs in RSV research heavily outweigh the negatives. The question is not whether there may be conflicts of interest for – there are. Rather, the goal is to work around those and achieve a fair, transparent, unbiased, and scientifically valid result that benefits all. We cannot pretend that the public sector owns public health: promoting clarity and transparency in clinical research is an intrinsic public health good and a shared responsibility of both academia and industry. While pure academic research is an important adjuvant to industry-supported development, it cannot replace the focus or scope of industry funding.

In the graceful choreography uniting academia and industry, the orchestrated symphony of PPPs unveils not just scientific advancements, but also weaves a melodic tapestry of collaborative determination that forges a future fortified against RSV.
RODA DE CONVERSA COMO ESTRATÉGIA PARA APRENDER E FLORESCER COM A PESSOA IDOSA: ESTUDO DE CASO
Authors: Ratiguieri Gisele Maria , de Oliveira da Silva Souza Eliane , Ramos Costa Maria Antonia , Gomes Labegalini Célia Maria
Published: October 2023

O estudo objetiva descrever uma estratégia de promoção da interação social de pessoas idosas participantes do Serviço de Convivência e Fortalecimento de Vínculos. Trata-se de um estudo de caso descritivo e exploratório desenvolvido com usuários idosos do Serviço de Convivência e Fortalecimento de Vínculos de um Centro de Referência da Assistência Social, localizado na cidade de Paranavaí, região noroeste do estado do Paraná. A promoção da interação social, cooperação e trabalho em equipe ocorreu por meio de atividades lúdicas que incentiva a igualdade, o pertencimento e a colaboração as quais, resultam em melhor qualidade de vida e fortalecimento das relações sociais. Para alcançar o desenvolvimento sustentável neste projeto, é necessário que a política pública adote abordagens inovadoras, investindo em recursos, sejam eles humanos ou  equipamentos, a fim de promover a inclusão social e criar um mundo mais justo, onde as necessidades das pessoas sejam atendidas. Neste caso a necessidade de fortalecer vínculos comunitários e ampliar a rede de apoio se dá por meio do resgate à cultura de visitas aos domicílios de pessoas idosas, com vista a minimizar o isolamento social.
HISTÓRICO E A IMPORTÂNCIA DA EXTENSÃO UNIVERSITÁRIA PARA A COMUNIDADE: O CASO DA UNIVERSIDADE ABERTA À TERCEIRA IDADE DA UNIOESTE DE FOZ DO IGUAÇU
Authors: Baill Anelize , Leão Oderich Cecília , Dos Santos Rivas Sara Tais , Serafim Júnior Valdir
Published: October 2023

As instituições de ensino superior formam a base da produção de conhecimentos científicos e tecnológicos que impulsionam o desenvolvimento das comunidades em que estão inseridas. O estudo tem como objetivo analisar, sob a ótica do desenvolvimento e da construção dos programas extensionistas no decorrer dos anos, o caso do programa de extensão da Universidade Aberta à Terceira Idade (UNATI) da Unioeste de Foz do Iguaçu, que tem como público-alvo cidadãos com idade a partir de 55 anos, apontando as principais iniciativas e atividades desenvolvidas ao longo dos anos, e que propiciaram maior qualidade de vida e melhoria das perspectivas e percepções quanto ao envelhecimento e amadurecimento. Para tanto, foi realizada pesquisa qualitativa com objetivo descritivo, fazendo uso de pesquisa bibliográfica e documental. A partir da construção da pesquisa, tornou-se evidente o grau de importância dos programas de extensão para o ambiente acadêmico e sociedade em geral, visto que se trata de método propulsor do desenvolvimento local e, no caso específico do programa de extensão UNATI, de Foz do Iguaçu, notou-se resultados positivos que propiciaram melhoras nas dimensões física e emocional dos participantes, principalmente no que tange à reinserção social, bem-estar, saúde, compreensão sobre o processo de envelhecimento, integração social, qualidade de vida e melhoria da perspectiva quanto à fase de vida em que se encontram.
RANCANG BANGUN SISTEM INFORMASI MANAJEMEN INVENTARIS BERBASIS WEBSITE MENGGUNAKAN METODE SDLC
Authors: Nadhia Annisya Nadhia , Suwarno Suwarno
Published: October 2023

Pemanfaatan sistem informasi telah memberikan dukungan bagi kegiatan operasional dalam menjalankan proses bisnis perusahaan secara cepat dan praktis.  Sistem manajemen inventaris menjadi salah satu contoh penerapan sistem informasi  dalam menyediakan kontribusi kepada perusahaan. PT.XYZ sebagai perusahaan sering menghadapi tantangan dalam manajemen inventaris. Pada penelitian ini, merancang suatu sistem manajemen inventaris yang dapat mengatasi kesulitan pengelolaan inventaris perusahaan. Sistem ini bertujuan untuk mengatasi permasalahan manajemen inventaris dengan pemantauan stok barang, pengecekan kerusakan dan perbaikan secara rinci, pelacakan penyimpanan dengan akurat, dan lainnya. Metode penelitian ini menggunakan metode System Development Life Cycle (SDLC) dengan model; prototype. Penelitian ini menghasilkan suatu sistem manajemen inventaris yang dapat mendata seluruh arus pengelolaan barang-barang inventaris menjadi lebih akurat, praktis, serta optimal.
RANCANGAN SISTEM PAKAR DIAGNOSA PENYAKIT PADA UDANG MENGGUNAKAN METODE FORWARD CHAINING BERBASIS WEB
Authors: Cawa Yohanes Valendry , Handoko Koko
Published: October 2023

The cultivation of vannamei shrimp has become the primary choice for shrimp farmers and breeders today. The superiority of this shrimp species lies in its resilience to stress and extreme weather conditions. However, the occurrence of diseases in cultivated shrimps remains a significant concern as it can lead to substantial losses if not properly addressed. This research aims to develop a web-based expert system to assist shrimp farmers and breeders in identifying the types of diseases affecting vannamei shrimp. The expert system employs the Forward Chaining method, allowing the system to infer and reach accurate disease diagnoses based on observed symptoms in the shrimp. The web-based nature of the system enables easy access for farmers and breeders through internet-connected devices. Utilizing PHP as the programming language and appserver as the database, the system gathers data provided by users about observed symptoms in the shrimp, subsequently performing inference to deliver precise diagnoses of potential diseases in vannamei shrimp. Leveraging the knowledge and expertise of fisheries experts, the system aims to provide more effective guidance in disease prevention and identification in vannamei shrimp. The expected outcome of this research is to contribute significantly to improving the management of vannamei shrimp cultivation, particularly in preventing and addressing diseases that may affect the shrimp. The expert system aims to empower farmers and breeders to swiftly recognize various diseases and take appropriate measures to maintain the health and productivity of vannamei shrimp cultivation.
PERANCANGAN SISTEM APLIKASI PENJUALAN SPAREPART MOTOR BERBASIS ANDROID
Authors: Febriana Vina , Putri Anggia Dasa
Published: October 2023

Currently the ongoing sales process in Bengkel Top 1 Motor requires the buyer to come and meet in person to purchase the required spareparts. This thus affects the sales process where buyers who come to look for spareparts equipment only reach buyers who are around the workshop, and conventional purchases require in-depth knowledge of employees about prices. System design is the best solution for solving problems and with a computerized system an activity can be achieved that effectively and efficiently supports workshop activities (Abdurrahman & Maspirah, 2017). The Agile development method has the stages used, namely the process of making a design based on mutual agreement in the form of interviews and observation (planning), coding and design (implementation), testing (testing), documentation, disseminating information (deployment), maintenance (Handayani et al., 2023) Apart from being used as an Android communication tool, Android can also be used as a platform to be accessed and developed easily because it supports several devices in making applications, one of which is Android games (Agis et al, 2021).From the problems experienced by the Bengkel Top 1 Motor, it is considered necessary to design a sales application so that the sales process is faster and more efficient.
PENDEKATAN DATA MINING UNTUK MEMILIH PRODUK TERLARIS MENGGUNAKAN ALGORITMA NAIVE BAYES
Authors: Rajagukguk Hidup Perjuangan , Fauzi Rahmat
Published: October 2023

Technological advances today can be exploited to process data into more useful information. In data collection, information collection is especially useful to maximize profits and develop marketing strategies. One way to increase profits is by using data mining techniques to help business actors in making decisions about stocks, increased profits and more. The Matahari Department Store is the largest retail platform in Indonesia, one of the retail stores located in Batam is the Matahari Department store Nagoya Hill Batam. The transaction data on the store that is still processed does not use a method that causes the processing of product sales data to be less effective and less efficient. Seeing from the number of transactions, a system is needed to predict the sale of the best-selling product as long as it can determine the correct stock for the products sold and can increase the profit, sale and purchase of the product. This research was conducted with the aim of applying data mining methods using the Naive Bayes Classifier algorithm to select the best-selling products in the outlet of the Matahari Nagoya Hill Batam Department Store. By using the collected sales data, the system is expected to increase profits steadily and avoid shortages of product stocks. Through analysis using the Naive Bayes Classifier method, the study achieved an accuracy of 67% and obtained a bag sales result to be the best-selling sale during January 2023 through March 2023 with a sales percentage of 20%.
PENGENDALIAN PERSEDIAAN SUKU CADANG FORKLIFT PADA UMKM ABDI JASA INDUSTRI
Authors: Rafiqi Galih , Tarigan Elsya Paskaria Loyda
Published: October 2023

UMKM ABDI JASA INDUSTRI merupakan perusahaan yang bergerak di bidang alat berat industri yaitu forklift dan generator set (genset). permasalahan khusus pada UMKM ABDI JAYSA INDUSTRI diantaranya: seringnya terdapat masalah dari jumlah suku cadang, ketidakpastian permintaan persediaan, baik jumlah suku cadang yang dipesan maupun jumlah suku cadang yang disimpan, belum adanya spesifikasi suku cadang dalam penentuan jumlah pemesanan suku cadang forklift, sehingga menyebabkan tempat penyimpanan suku cadang tidak cukup. Penelitian ini bertujuan untuk mengklasifikasikan suku cadang tersebut sehingga mendapatkan jumlah pemesanan yang optimal meliputi ukuran lot per tiap kali pesan, titik reorder point yang jelas, dan adanya safety stock sebagai antisipasi jika terjadi hal yang tidak diinginkan serta perusahaan dapat memperoleh total biaya persediaan yang lebih hemat, yang menjadi permasalahan adalah Persediaan yang tidak terkendali sehingga mengakibatkan tempat penyimpanan suku cadang tidak mencukupi. Tujuan dari penelitian ini adalah untuk mengetahui jumlah persediaan dan pengendalian suku cadang dengan menggunakan metode continuous review system. Berdasarkan dari hasil analisa, pengolahan data, hasil & implementasi dan juga pembahasan, dari data yang di ambil dari penelitian dalam hal membuat pengendalian persediaan suku cadang forklift didapatkan hasil forecasting yang memiliki eror terkecil (MAD) untuk masing-masing suku cadang. MAD pada suku cadang seal plunger adalah 1.25, Battery 0.6, Ban 1.325, King Pin Kit 2.925, Filter Solar 6.25, dan kampas rem 0.925, Dan juga didapatkan hasil forescasting untuk 1 bulan kedepan (agustus) untuk tiap suku cadang adalah: cadang seal plunger 24.4, Battery 3, Ban 7, King Pin Kit 13.3, Filter Solar 24, dan kampas rem 13. Dan didapatkan Hasil penghematan persediaan sebesar Biaya Total Rp25.595.310,00 atau sebesar 6.75%.
RANCANG BANGUN SISTEM INFORMASI MANAJEMEN KARYAWAN
Authors: Purba Leo Jhon Sinar , Amrizal Amrizal
Published: October 2023

The employee management information system at Nazra Swim School (NSS) was created with the aim of improving the performance and service of employees at Nazra Swim School (NSS). Nazra Swim School has a lot of data, one of which is employee data that needs to be stored and processed. Employee data processing is currently still done manually. To facilitate the processing of employee data, an information system is needed to process employee data so that the resulting information is more accurate, efficient and precise. This employee management information system is done using the waterfall method. This information system design includes document flowcharts, system flowcharts, data flow diagrams, context diagrams, database design, conceptual data model (CDM), physical data model (PDM) and user interface design. The employee management information system is designed using the programming language PHP, Notepad++ and MySQL database. implementation of a web-based employee management information system can help administration and employees in managing employee data automatically.
Advances in dendritic cell targeting nano-delivery systems for induction of immune tolerance
Authors: Lin Guojiao , Wang Jialiang , Yang Yong-Guang , Zhang Yuning , Sun Tianmeng
Published: October 2023

Dendritic cells (DCs) are the major specialized antigen-presenting cells (APCs), play a key role in initiating the body’s immune response, maintain the balance of immunity. DCs can also induce immune tolerance by rendering effector T cells absent and anergy, and promoting the expansion of regulatory T cells. Induction of tolerogenic DCs has been proved to be a promising strategy for the treatment of autoimmune diseases, organ transplantation, and allergic diseases by various laboratory researches and clinical trials. The development of nano-delivery systems has led to advances in situ modulation of the tolerance phenotype of DCs. By changing the material composition, particle size, zeta-potential, and surface modification of nanoparticles, nanoparticles can be used for the therapeutic payloads targeted delivery to DCs, endowing them with great potential in the induction of immune tolerance. This paper reviews how nano-delivery systems can be modulated for targeted delivery to DCs and induce immune tolerance and reviews their potential in the treatment of autoimmune diseases, organ transplantation, and allergic diseases.
Plasticity in the cell division processes of obligate intracellular bacteria
Authors: Harpring McKenna , Cox John V.
Published: October 2023

Most bacteria divide through a highly conserved process called binary fission, in which there is symmetric growth of daughter cells and the synthesis of peptidoglycan at the mid-cell to enable cytokinesis. During this process, the parental cell replicates its chromosomal DNA and segregates replicated chromosomes into the daughter cells. The mechanisms that regulate binary fission have been extensively studied in several model organisms, including Eschericia coli, Bacillus subtilis, and Caulobacter crescentus. These analyses have revealed that a multi-protein complex called the divisome forms at the mid-cell to enable peptidoglycan synthesis and septation during division. In addition, rod-shaped bacteria form a multi-protein complex called the elongasome that drives sidewall peptidoglycan synthesis necessary for the maintenance of rod shape and the lengthening of the cell prior to division. In adapting to their intracellular niche, the obligate intracellular bacteria discussed here have eliminated one to several of the divisome gene products essential for binary fission in E. coli. In addition, genes that encode components of the elongasome, which were mostly lost as rod-shaped bacteria evolved into coccoid organisms, have been retained during the reductive evolutionary process that some coccoid obligate intracellular bacteria have undergone. Although the precise molecular mechanisms that regulate the division of obligate intracellular bacteria remain undefined, the studies summarized here indicate that obligate intracellular bacteria exhibit remarkable plasticity in their cell division processes.
Mid-T heat treatments on BCP’ed coaxial cavities at TRIUMF
Authors: Kolb P. , Yao Z. , Blackburn A. , Gregory R. , Hedji D. , McMullin M. , Junginger T. , Laxdal R. E.
Published: October 2023

Mid-T heat treatments in the range from 250°C to 400°C on superconducting radio-frequency (SRF) cavities have been shown to provide high quality factors that rise with applied rf field strength in high frequency, electro-polished (EP), elliptical cavities operating at 2 K, similar to nitrogen doped cavities. The rise in quality factor is attributed to a decrease in the temperature dependent part of the surface resistance RBCS. Until now, no results have been reported for these new treatments on quarter-wave resonators (QWR) and half-wave resonators (HWR). The TRIUMF multi-mode coaxial cavities are dedicated test cavities that allow frequency and temperature resolved performance characterization of treatments without changing environments, therefore providing an excellent test vehicle to test these new treatments with rf frequencies ranging from 200 to 1,200 MHz. In this paper, performance measurements from both QWR and HWR cavities are reported and their performance compared with four different treatments: baseline, a conventional 120°C low temperature bake for 48 h, and two mid-T bakes at 300°C and 400°C for 3 h. In addition, sample analysis using SEM, EDX and SIMS of witness samples is also shown. It is found that the mid-T bakes are not directly transferable to low frequency cavities. In the fundamental modes of the two test cavities, no performance gain over the baseline treatment nor a decreasing temperature dependent component with rising rf amplitude was observed. At frequencies above 1 GHz and low temperatures, the mid-T bakes show a reduced field dependence of RBCS compared to both the baseline and 120°C treatments.
SIRT6’s function in controlling the metabolism of lipids and glucose in diabetic nephropathy
Authors: Wang Ying , Liu Tongtong , Cai Yuzi , Liu Weijing , Guo Jing
Published: October 2023

Diabetic nephropathy (DN) is a complication of diabetes mellitus (DM) and the main cause of excess mortality in patients with type 2 DM. The pathogenesis and progression of DN are closely associated with disorders of glucose and lipid metabolism. As a member of the sirtuin family, SIRT6 has deacetylation, defatty-acylation, and adenosine diphosphate-ribosylation enzyme activities as well as anti-aging and anticancer activities. SIRT6 plays an important role in glucose and lipid metabolism and signaling, especially in DN. SIRT6 improves glucose and lipid metabolism by controlling glycolysis and gluconeogenesis, affecting insulin secretion and transmission and regulating lipid decomposition, transport, and synthesis. Targeting SIRT6 may provide a new therapeutic strategy for DN by improving glucose and lipid metabolism. This review elaborates on the important role of SIRT6 in glucose and lipid metabolism, discusses the potential of SIRT6 as a therapeutic target to improve glucose and lipid metabolism and alleviate DN occurrence and progression of DN, and describes the prospects for future research.