bluuebunny/crossref_metadata_2025 huggingface dataset:
Researching the force absorption system for the front of the passenger car to secure the driver
Authors: Vu Hoang Phuong  , Tung Pham Son  , Duong Hoang Ngoc  , Nguyen Nguyen Khoi
Published: April 2024

Protecting the safety of drivers in the bus is very important and necessary in front collisions. This research on the system shock absorber and absorption of force bus head in front collisions. This design will protect bus heads not violations in safe spaces and protect drivers in front collisions. The finite element model and safety analysis simulation of the system shock absorber and absorption of force by LS – DYNA and MADYMO software. The study’s results show shock absorber structure ensures durability. The head part index is down 35%. The neck part index is down 28%. Drivers are protected more safely. Injury values of driver satisfy safety ECE R94 standard in bus front collision.
Keywords: ECE R94 standard, MADYMO software, LS - DYNA software, collision, injury.
ANALYSIS OF LANDSLIDE SUSCEPTIBILITY IN KLATEN REGENCY
Authors: Febriana Oryza , Saputra Aditya
Published: April 2024

Landslide disasters are frequently occurring events in Indonesia. The northern part of Klaten Regency, situated on the slopes of Mount Merapi, and the southern part, which directly borders limestone hills, are vulnerable to landslides due to their elevated terrain. This research aims to investigate the role of Geographic Information Systems (GIS) in analyzing, mapping, and identifying areas prone to landslide disasters. Mapping landslide susceptibility as a GIS application aims to be a disaster mitigation effort, thereby minimizing the resulting impacts and losses. The mapping is conducted based on the Puslattinak method, using several parameters such as rainfall, slope, rock types, land use, and soil types. This mapping employs a weighted multi-level analysis method, where each parameter has a different weight depending on its influence on landslide disasters. The results of this research include the Landslide Susceptibility Map of Klaten Regency in 2022. According to the research findings, Klaten Regency is divided into three susceptibility classes: low (17,868.23 hectares), medium (41,494.22 hectares), and high (10,533.96 hectares), with rainfall intensity being the most influential parameter
A referrals audit and qualitative analysis of staff experience of referrals in a specialist community learning disability service
Authors: McMahon Natalie , Warner Katie , Scott Jacqui
Published: April 2024

PHOTO CREDIT: Aaron Burden

Specialist community teams are set up to support people living with Learning Disability (LD) who are unable to access mainstream mental health (MH) teams with reasonable adjustments. National guidance is available to guide best practice in making reasonable adjustments, to support increased access to mainstream services. This audit of referrals into a specialist Community LD team, aimed to establish referral acceptance rates and reasons for referral rejection. Total referrals and referrals made specifically from mainstream MH teams were investigated. A focus group explored LD clinicians’ experiences of the referral process and criteria in the context of working alongside mainstream MH teams. A lower acceptance rate of referrals from mainstream MH teams than overall acceptance rate was found, and differences in the reasons for rejection were highlighted. No LD diagnosis in the referral was the most common rejection reason for mainstream MH team referrals. Thematic analysis highlighted four themes of clinician’s experiences which focused on: referral point struggles; service limitations; lack of diagnostic clarity; and attempts to bridge a gap between services. Recommendations include review of the referral process, joint working protocols, clarification of remit and dissemination of shared learning.
Equality or equity? Sex differences in attitudes toward females’ sports opportunity and Title IX
Authors: Mikulyuk Ashley B. , Milner Adrienne N. , Braddock Jomills H.
Published: April 2024

Title IX of the 1972 Education Amendments to the Civil Rights Act of 1964 was introduced to equalise educational opportunities between males and females in the United States, including access to schoolbased activities, such as sport. Despite resistance, Title IX has contributed to a tremendous increase in female athletic participation in the US. Research on the contested nature of Title IX has focused mainly on either legal or policy debates, with little attention to equally important disagreements in the court of public opinion. This study examines public perceptions of the significance of gender equality in sport and public support of Title IX as an equity policy. Specifically, we examine two mechanisms to explain feminist opinions surrounding gender and sport: interest-based and exposure-based attitudes. Results show that a majority of the American public currently favors both gender equality in sport and Title IX; however, a significant sex gap remains in public support. Interestingly, male athletes are more likely to support gender equality and Title IX than non-athlete males. These results show potential evidence of feminist attitudes in sport reflecting an interest-based explanation for women and an exposure-based explanation for men.
Mechanical Characterization and Dynamic Mechanical Analysis of Recycled Low Density Polyethylene Filled Unsaturated Polyester Composite
Authors: Adegboro Narcillina Nkechi , Isa Muhammed Tijjani , Bello Tajudeen Kolawole
Published: April 2024

Unsaturated polyester resin (UPR) is widely used as matrix in composite development; however, it has poor toughness property. To solve this problem, many researchers have used different tougheners to modify the resin, but the use of recycled low-density polyethylene (RLDPE) has not been explored. This work is aimed at modifying unsaturated polyester resin (UPR) with recycled low-density polyethylene (RLDPE) as a toughener and establishing the effects on the mechanical and dynamic mechanical performance of the RLDPE-filled polyester composite. Unsaturated polyester resin was modified with 1.18 mm RLDPE at different proportions of 1-4 wt%. Casting method was used for the production and the mechanical and dynamic mechanical analyses of the produced composite materials were carried out using ASTM standards. UPR modified with 1.5 wt% RLDPE exhibited the best impact than the un-modified UPR.  The control (un-modified) sample had the highest flexural and tensile strength of 18 MPa and 14.02 MPa respectively which was about 26% and 25% higher than UPR modified with 1 wt% RLDPE. The Dynamic Mechanical Analysis (DMA) result showed that the composite does not depend strongly on the modifier loading as no regular pattern was observed for storage modulus, loss modulus and damping factor respectively.
Double star permanent magnet synchronous machine: modified direct torque control
Authors: Bachir Naas , M’hamdi Benalia , Abderrahmane Amari , Badreddine Naas
Published: April 2024

In the area of high power drives, double star synchronous machines are an interesting choice compared to conventional synchronous machines, due to the relatively low torque ripple created. In this paper, direct torque control (DTC) of double star permanent magnet synchronous machine (DS-PMSM) using artificial neural networks (ANN) is proposed. MATLAB/Simulink results show the comparison between direct torque control (DTC) and direct torque control using artificial neural networks (ANN). The analysis of the results shows good performance for speed, small torque and flow ripple when using the artificial neural network (ANN) strategy.
Uso de ácido hialurônico em cirurgias ortopédicas: uma análise de literatura
Authors: Souza Arthur Vinicios Araújo de , Almeida Filho Jhenifer de , Silva Pablo Augusto Araujo , Vidal Luisa Moura , Souza Natalia Quaresma de , Jesus Carlos Henrique Silva de , Silva Amanda Macêdo da , Teixeira Mariana Dias , Holanda Nicole Costa de , Silva Alexia Beatria da , Domingos Lucas Tavares , Silva Laryssa Engrácia da , Rodovalho João Gabriel Marion , Silveira Victoria Hemilly de Moraes , Leão Rafaela Costa , Holanda Lorena Costa de , Gomes Lucca Alves , Menezes Mariana Mello , Menezes Filho Douglas Araujo
Published: April 2024

A artroplastia é um procedimento cirúrgico destinado a aliviar a dor e restaurar a mobilidade, alinhando ou reconstruindo uma articulação. Este processo pode causar um trauma significativo nos tecidos, resultando em dor intensa pós-operatória, o que torna a analgesia crucial para a estabilidade do paciente durante o período de recuperação. Com isso é feito analgesia geralmente alcançada com injeções em bolus de anestésicos locais de ação rápida ou com o uso de analgésicos orais, como os opióides, que têm potencial para efeitos colaterais sistêmicos. Com o advento das terapias, a fim de suplementar de forma a diminuir efeitos adversos, foi visto que desde sua descoberta em 1934, o AH tem sido aplicado em uma variedade de áreas médicas. Sua versatilidade e eficácia o tornaram particularmente um muito popular na prática, onde é amplamente utilizado como preenchimento adjuvante a cirurgias ortopédicas, sendo a escolha preferida de muitos cirurgiões devido à sua capacidade de fazer o papel que um opioide estaria fazendo, proporcionando um aspecto com menos efeitos adversos e com uma melhor suplementação da área condral. Além disso, o AH oferece a possibilidade de uma terapia baseada na viscossuplementação. Realizou-se uma revisão sistemática de literatura por meio da plataforma pubmed, com seleção e análise criteriosa dos artigos, a fim de elucidar os aspectos do ácido hialurônico em cirurgias ortopédicas como modalidade terapêutica adjuvante a analgesia e melhora de prognóstico pós cirúrgico. Nesta revisão foi identificada uma relação positiva no seu mecanismo de ação, onde o AH atua bioquimicamente, diminuindo a expressão gênica de citocinas e enzimas associadas à osteoartrites, diminuindo a produção de prostaglandinas e a concentração intra-articular de metaloproteinases. Sua presença tem efeito analgésico, reduzindo os impulsos nervosos e a sensibilidade nas terminações nervosas nociceptivas, estabilizando a matriz cartilaginosa, estimulando a proliferação de condrócitos, aumentando a produção de colágeno tipo 2 e agregados de condrócitos e diminuindo a degradação do colágeno tipo 2. A análise busca contribuir para um entendimento mais aprofundado dos benefícios, da sua eficácia, segurança e prognóstico visto que altera o contexto da função articular no contexto cirúrgico.
3,5-Dimethyladamantan-1-amine Restores Short-term Synaptic Plasticity by Changing Function of Excitatory Amino Acid Transporters in Mouse Model of Spinocerebellar Ataxia Type 1
Authors: Belozor Olga S. , Vasilev Alex A. , Mileiko Alexandra G. , Mosina Liudmila D. , Mikhailov Ilya G. , Shuvaev Andrey N. , Shuvaev Anton N.
Published: April 2024

Introduction. Memantine is an agent that used for treatment of Alzheimer's type dementia. Memantine considerably reduces the effects of neurodegeneration, may potentially slow down the neurodegenerative changes in the cerebellum and may act as treatment of choice for spinocerebellar ataxia type 1 (SCA 1).
Our objective was to study molecular mechanisms of the short-term synaptic plasticity improvement associated with long-term memantine use in SCA 1 transgenic mice.
Materials and methods. The experiments were performed on 12-week-old CD1 mice. We created a mouse model of cerebellar astrogliosis after expression of mutant ataxin-1 (ATXN1[Q85]) in the Bergmann glia (BG). To model the astrocyte-mediated neurodegeneration in the cerebellum, the mice were injected with LVV GFAP-Flag-ATXN1[Q85] lentiviral vector (LVV) constructs intracortically. Some of the mice received 0.35 mg/kg memantine dissolved in drink water once daily for 9 weeks. The control animals were administered LVV GFAP-ATXN1[Q2]-Flag. Changes of the excitatory postsynaptic currents amplitudes from Purkinje cells (PC) were recorded by patch clamp. Expression of anti-EAAT1 in the cerebellar cortex was assessed using immunohistochemistry.
Results. The reactive glia of the cerebellar cortex in SCA1 mice is characterized by a decrease in the immunoreactivity of anti-EAAT1, while chronic memantine use restores this capacity. The decay time of the excitatory postsynaptic current amplitude in the parallel fiber-Purkinje cell (PF-PC) synapses of the SCA1 mice is considerably longer, which indicates the slowing of glutamate reuptake and EAAT1 dysfunction. The prolonged presence of increased neurotransmitter levels in the synaptic cleft facilitates activation of the mGluR1 signaling and restoration of mGluR1-dependent synaptic plasticity in Purkinje cells of the SCA1 mice.
Conclusions. The slowing of neurotransmitter reuptake associated with long-term memantine treatment improves mGluR1-dependent short-term synaptic plasticity of the Purkinje cells in the SCA1 mice. Restoration of synaptic plasticity in these animals may underlie partial reduction of ataxic syndrome.
Neuroplasticity, music, and human brain
Authors: Bogolepova Irina N. , Krotenkova Marina V. , Konovalov Rodion N. , Agapov Pavel A. , Malofeeva Irina G. , Bikmeev Alexander T.
Published: April 2024

Introduction. Studying the influence of music on the human brain is one of the key topics in neuroscience as it allows extending our understanding of brain neuroplasticity.
This study aimed to investigate structural brain organization in professional musicians.
Materials and methods. We investigated 27 brains (i.e. 54 hemispheres) of male musicians, female musicians, male non-musicians, and female non-musicians by magnetic resonance imaging. All study participants were aged 20 to 30 years and did not have any mental or neurological disorders. Gray matter volume and cortex thickness in different cortical structures of the right and left hemispheres were measured.
Results. We found major changes in the brain structure in professional musicians (both male and female) vs. non-musicians. We found differences in the macroscopic structure of the triangular region in the Broca’s motor speech area in musicians’ brain. Increases in gray matter volume in the brain of musicians and its individual cortical structures were shown in the superior temporal region, Broca’s motor speech area, hippocampus, superior parietal lobule, and other structures. We found increased thickness of cortical structures in musicians vs. non-musicians.
Conclusions. Practicing music regularly was shown to change structural brain organization; we found significant increases in gray matter volume and cortex thickness in various cortical structures in the right and left brain hemispheres of musicians vs. non-musicians.
Budaya Sekolah Dalam Mendorong Pembinaan Guru
Authors: Sabariah Sabariah , Hartono Hartono , Zairunah Zairunah , Lian Lisda
Published: April 2024

School culture is one of the factors influencing school management systems in efforts to improve teacher performance. The research aims to determine and explain school culture in fostering teacher development. This study uses a qualitative phenomenological approach. Data collection techniques were conducted through observation, interviews, and document studies. Data validity was ensured through triangulation of sources, techniques, and prolonged observation. The results of the study indicate: (1) school culture: motivating teachers to work, disciplining teachers through the socialization of school rules and checking teacher attendance, conducting regular meetings among teachers, and building positive communication between the school principal and teachers and among teachers. (2) impacts: improved teacher performance and smooth management of learning activities. Conclusion: school culture has been implemented effectively and systematically. Research implications: serving as input and learning materials for other schools in teacher development.
Hubungan Bimbingan Orang Tua dengan Prestasi Belajar Siswa
Authors: Kaitotak Hasni , Sere Idrus , Saidah Ummu
Published: April 2024

This study aims to determine the relationship between parental guidance and student achievement in PAI subjects in grade VII of SMP Muhammadiyah Ambon. The type of research used is quantitative descriptive, which is research that aims to determine the relationship between parental guidance and student learning achievement in PAI subjects in grade VII of SMP Muhammadiyah Ambon. The sample used in this study was taken randomly amounting to 26 people. The instruments used are tests and questionnaires. Tests are used to determine student achievement and questionnaires are used to determine parental guidance. The data analysis technique used is Product Moment Correlation. The results of the data analysis found that there is a strong relationship between parental guidance and student achievement in Islamic Religious Education subjects in grade VIII of SMP Muhammadiyah Ambon. This is based on the results of the hypothesis test using the product moment correlation test obtained, namely the calculated value obtained of 0.7376. While the conversion results based on the rtabel value distribution table are obtained ttable value which is 0.388.
Physiological impact of a single cup of coffee on systemic blood pressure and heart rate – A randomized controlled trial
Authors: Syed Imran , G Jhasya , S Bhuvan , P Aarya , L Sanjana , N Habeeba , K Esitha , S Sriya
Published: April 2024

Background: Coffee is a prevalent beverage that is consumed on a global scale. This study was done to depict the immediate effects of caffeine on systemic blood pressure (BP) and heart rate (HR) in young healthy, normotensive individuals who consume coffee on an infrequent basis, using validated non-invasive techniques. The acute properties of caffeine have been the subject of numerous studies, and we’ll be exploring the latest findings on this topic. Thus, we think that it is more useful to ascertain if a typical cup of coffee can produce a significant rise in BP and HR.

Aims and Objectives: This research aimed to examine the effect of a single cup of coffee on the HR and BP of young healthy adults.

Materials and Methods: The study was conducted on 68 participants from 1st-year MBBS students enrolled in the study of those 4 were excluded as two males showed systemic BP of >140/80 and we have excluded two females to maintain an equal male and female ratio. In a randomized double-blind, placebo-controlled study, 64 healthy subjects were first divided into caffeine and placebo groups. One cup of coffee and a placebo drink were administered orally to 64 healthy, normotensive adults, and BP (systolic BP [SBP], diastolic BP [DBP]) and HR were observed.

Results: Administration of caffeine shows increased systolic and DBP from 0 to 30 min after coffee intake was significantly higher in the caffeine group than in the placebo group. The mean SBP, DBP at 90 min in the caffeine group was compared to the mean SBP, DBP at 90 min in the placebo group. The mean difference in both was statistically significant with a P < 0.001.

Conclusion: The present study concludes that the ingestion of a single cup of caffeinated coffee may elicit a significant increase in both systolic and DBP, as well as in HR, among young, healthy, and sporadic coffee consumers. Notably, such a rise in physiological parameters may interfere with the accuracy of BP measurements taken in the few hours following coffee intake, especially in individuals who consume coffee on an occasional basis.
A cross-sectional comparative assessment of diabetic autonomic neuropathy using heart rate variability and galvanic skin response – Effect of disease progression
Authors: Kaur Prabhpreet , Jain Aditya , Jhamb Shikha , Kumar Avnish , Singh Kamal , Goyal Sanjay
Published: April 2024

Background: Type 2 diabetes mellitus (T2DM) poses a significant health-care challenge and is a primary contributor to both mortality and morbidity. Diabetic autonomic neuropathy (DAN) is a frequently occurring complication associated with diabetes mellitus. Autonomic nerve damage leading to cardiac autonomic dysfunction and peripheral sympathetic neuropathy can lead to changes in heart rate variability (HRV) and galvanic skin resistance (GSR), respectively.

Aims and Objectives: The study was designed and done to evaluate the impact of T2DM on HRV and GSR for assessing DAN.

Materials and Methods: A total of 100 individuals diagnosed with T2DM (cases) and 100 healthy individuals (controls) participated in this study. Physio Pac (PC-2004) was used to record the necessary data. Statistical analysis was performed using the non-parametric Mann–Whitney test to see the comparison of the cases and controls. In addition, to measure the statistical relationship between the duration of the disease and the HRV and GSR parameters, Spearman’s rank correlation coefficient was utilized. The study received approval from the Ethical and Research Committee at the Government Medical College, Patiala.

Results: Significant statistical differences were observed between the cases and controls in all time domain measures, as well as GSR and the majority of frequency domain measures of HRV. The correlation analysis revealed a strong association between the duration of T2DM and a decrease in HRV as well as an increase in GSR.

Conclusion: The findings from the present study provide evidence that T2DM has an impact on HRV, which suggests the presence of cardiac autonomic neuropathy among diabetic patients, leading to an increased risk of cardiovascular morbidity. In addition, the study indicates that reduced sudomotor function, as assessed by Galvanic Skin Resistance (GSR), serves as a predictive measure for autonomic neuropathy. Therefore, these tests can serve as valuable tools in facilitating the assessment of DAN.
A Morphometric Analysis of Suid Remains of the genus Conohyus from the Siwalik Beds of District Jhelum, Punjab, Pakistan
Authors: Amir Nadeem
Published: April 2024

The current fresh Suid dental material was gathered from Pakistan's Siwalik hills, which are located in Punjab and stretch into Northern Pakistan. There have been reports of fossils being found at sites belonging to this genus in the Hasnot hamlet, which is situated in the Punjab province of Pakistan in the district Jhelum region. These particular examples are representatives of a small suid genus called Conohyus, which is commonly found in the Siwalik Mountains. The material that has been analyzed has provided a significant amount of insight into the underlying dentition that is typical of this genus. The teeth of the genus Conohyus are a little more advanced than the condition found in the genus Palaeochoerus.
Evaluation of Antibacterial Activity of Fruit Juices on Clinical and non-Clinical Enterotoxigenic, biofilm-producing Methicillin Resistance Staphylococcus aureus
Authors: Saba Riaz  , Hafiza Iqra Abdul Rasheed  , Asad Ali  , Muhammad Hassan Saeed  , Noor Aqsa  , Sikander Sultan
Published: April 2024

The drug-resistance behavior of Methicillin-resistant Staphylococcus aureus (MRSA) has made it difficult to treat. This study aimed to discover some fruit juice's anti-MRSA potential and the presence of enterotoxin genesin MRSA.MRSA strains were confirmed phenotypically by the disc diffusion method. The well-diffusion method and Minimum inhibitory concentration (MIC)were used to determine the antibacterial effects of fruit juices. Congo red test and ring tests were performed to analyze the biofilm-forming ability. PCR detected staphylococcal enterotoxin genes Sea and Seg. A total of 90strains, of which 26 nonclinical and 64 clinical samples were processed. Ciprofloxacin (CIP) was highly resistant to MRSA in both groups. In clinical isolates, Citrus reticulate has shown the maximum antibacterial activity against 67.1% MRSA, whereas, Punicagranatum was most effective for 46.1% strains isolated from non-clinical sources. Punicagranatum and Citrus reticulate were inhibiting the growth of MRSA at the concentration of >64μl/ml in both groups. Both Congo red and ring tests determined the biofilm-forming ability in 57.60% and 65.30% of non-clinical strains, respectively. Enterotoxin-producing gene Sea was detected in 8% of MRSA in the non-clinical group and only 2% in the clinical group. Seg and the co-existence of both genes were found in the same ratio in both groups. This study showed that fruit juices, especially pomelo, orange, and pomegranate, have high antibacterial activity. Enterotoxin genes play a role in the spread of infections caused by MRSA.
A Review on Advancement of Cancer Therapy with Metal Based Nanoparticle
Authors: Muhammad Irfan  , Affifa Tajammal  , Ansa Gulnaz  , Mehtab Shareef
Published: April 2024

The primary cause of numerous diseases that frequently affect the human body is a compromised immune system. For instance, it can increase the body's susceptibility to infection, which also increases the body's resistance to medicines, by triggering pro-inflammatory reactions and even the loss of good cells and tissues. Metal nanoparticles have the potential to overcome the challenges caused by conventional chemotherapies. Metal nanoparticles play an essential role in the treatment of cancer by targeting, gene suppression, and drug delivery to thetargeted area. The best suitable metal nanoparticles better work with targeted ligands to control the energy deposition within the tumors. Other than therapeutic advantages, metal nanoparticles are also helpful as a diagnostic tool for the imaging of cancerous cells. Moreover, metal nanoparticles provide beneficial options in controlled targeted drug delivery, instant diagnosis, and therapeutic methods. Nanoparticles are useful as therapies and diagnostics because cancer cells are heterogeneous. Breast cancer anti-cancer therapy is difficult due to the disease's aggressive spread to the body. Noble metal nanoparticles are used in the treatment of cancer because of their distinctive features, great biocompatibility, surface effects, and tiny size effects. Numerous cancer treatments have been developed thanks to advances in science and technology, but the global mortality rate for cancer patients is still astronomically high, necessitating conventional treatment approaches in order to preserve lives. Scientists are trying to find a cancer cure, working day and night. Due to their effectiveness and promising outcomes, nanoparticles for the treatment of cancer have acquired relevance.
A POSSIBILIDADE DE APLICAÇÃO DA PRESCRIÇÃO INTERCORRENTE NO PROCESSO ADMINISTRATIVO FISCAL
Authors: Braga Júnior Afonso Celso
Published: April 2024

O presente artigo tem como escopo o enfrentamento do instituto da prescrição intercorrente, bem como de sua aplicabilidade na seara dos processos administrativos fiscais. Em um primeiro momento, discorreremos sobre o conceito do instituto, sua disposição legal e construção doutrinária. Ato contínuo, o presente trabalho pretende explicitar a possibilidade de aplicação ou não do instituto da prescrição intercorrente no âmbito do processo administrativo fiscal, perpassando pela legislação aplicável ao caso e princípios constitucionais deflagrados e intimamente correlacionados.
Perlindungan Konsumen Dalam E-Commerce Terkait Kerugian
Authors: Maulana Muhammad Johansyah
Published: April 2024

Transaksi jual beli mengalami perkembangan seiring berjalannya waktu seiring dengan kemajuan teknologi. Transaksi jual beli yang dulunya dilakukan secara tradisional kini dilakukan secara online. Namun transaksi jual beli online sering kali melibatkan tindak pidana, termasuk tindak pidana penipuan. Sering kali, setelah pembayaran dilakukan oleh konsumen, perusahaan tidak mengirimkan produk yang dipesan atau mengirimkan produk yang tidak bersesuaian dengan informasi yang dijanjikan oleh pelaku komersial. Dengan demikian, dibutuhkan upaya hukum guna memberi efek jera kepada penipu pembelian dan penjualan internet. Riset ini ditujukan guna mengidentifikasi perlindungan hukum yang diberikan kepada pelanggan dalam transaksi jual beli online dan mengetahui langkah hukum yang bisa dilakukan pelanggan manakala terdapat kerugian dalam transaksi jual beli online. Metode penelitian yang diterapkan ialah pendekatan hukum normatif dan studi literatur data sekunder melalui inventarisasi dokumen hukum sekunder, dokumen hukum sekunder telah digunakan dalam bentuk makalah akademis, jurnal, artikel dan literatur terkait proteksi hukum dalam transaksi jual beli online. Temuan riset ini di antaranya ialah proteksi hukum kepada pelanggan dalam bertransaksi jual beli online melalui penegakan hak-hak pelanggan sesuai dengan UU Perlindungan Konsumen No. 8 Tahun 1999, dan pelaksanaan perlindungan konsumen juga dilakukan melalui keterlibatan berbagai pihak seperti pemerintah, otoritas negara, lembaga dan lembaga yang bertanggung jawab di bidang perlindungan konsumen. Swadaya sosial di bidang perlindungan konsumen.
Perlindungan Hukum Terhadap Hak-Hak Buruh Pasca Kecelakaan Kerja Dengan Pendekatan Analisis Yuridis Di Lingkungan Perusahaan
Authors: Hakim Rusydi
Published: April 2024

Perlindungan hukum terhadap hak-hak buruh pasca kecelakaan kerja merupakan aspek kritis dalam lingkungan perusahaan yang menuntut perhatian khusus. Studi ini bertujuan untuk menganalisis aspek-aspek yuridis yang terkait dengan perlindungan hukum terhadap hak-hak buruh setelah mengalami kecelakaan kerja di lingkungan perusahaan. Pendekatan analisis yuridis digunakan untuk menggali informasi dari studi pustaka yang relevan. Studi pustaka mengungkapkan bahwa sistem perlindungan hukum terhadap buruh pasca kecelakaan kerja memiliki landasan normatif yang kuat dalam undang-undang ketenagakerjaan. Namun, implementasinya di lingkungan perusahaan sering kali menghadapi tantangan, seperti keterbatasan sumber daya dan pemahaman yang rendah terhadap hak-hak buruh. Selain itu, ketidakpastian hukum dan prosedur administratif yang kompleks juga memengaruhi efektivitas perlindungan hukum ini.
The rate and Extent of absorption of oral Meptazinol 200 mg on healthy volunteer
Authors: Alaa- Eldin Ahmed adel , Mohamed Fahmy Mohamed Ibrahim , A.Eliwa Hesham.
Published: April 2024

Meptazinol is a centrally acting analgesic belonging to the hexahydro-azepine series, which has demonstrated mixed agonist and antagonist activity at opioid receptors.Receptor binding studies have shown that although meptazinol displays only a low affinity for μ and k opioid receptor sites, it has a some what higher affinity for the subpopulation of μ sites. These binding sites also displays a high affinity for the endogenous opioid peptides, and are thought to be responsible for, among other things, analgesia, but not for the mediation of respiratory depression. A component of its analgesic action is also attributable, in mice at least, to an effect on central cholinergic transmission. In this respect it differs from all conventional analgesic drugs which have been examined (1).Based on this information this drug requires no blocking of opioid receptor during the bioequivalence study. But to achieve the highest degree of safety, close monitoring will be performed to detect the occurrence of any side effect, As well as Anarchole 50mg tablets (Naltrexone, the opioid blocker) will be available at the emergency drugs store to treat any opioid side effect
Interesting and Uninteresting Unknowns
Authors: Giovannetti-Singh Gianamar
Published: April 2024

This article explores the stark visual and epistemic contrasts between early modern representations of uncertain southern African spaces produced in the metropolitan Dutch Republic and the Cape Colony, respectively. It emphasizes the importance of metropolitan and colonial mapmakers’ different material interests in shaping their disparate visual cultures. Southern Africa was a heterotopia, viewed differently through metropolitan and settler eyes, and its visualization was interest-driven. Thus, the article argues, early modern representations of uncertain southern African topographies should be analyzed neither just as verisimilar descriptions nor as emptied or exoticized fantasies. Rather, the article proposes studying the epistemic and visual cultures of mapping with the perspective-dependent categories of interesting and uninteresting unknowns. Interesting unknowns tended to be illustrated in a straightforward, ostensibly representationalist manner, whereas uninteresting unknowns became sites for mapmakers to project delocalizing fantasies. Based on their dissimilar geopolitical perspectives and material interests, metropolitan Dutch and colonial creolized Cape mapmakers viewed different geographical unknowns as interesting or uninteresting. Thus, this article contends, scholars ought to pay more attention to the unique contexts that shaped their disparate depictions of the unknown.
THE EFFECT OF FIXED ASSETS VALUE, REGIONAL ORIGINAL INCOME AND CAPITAL EXPENDITURES ON MAINTENANCE EXPENDITURES IN THE DISTRICT/CITY OF SOUTH SUMATRA PROVINCE
Authors: Andini Melda Novri , Arifin Kiagus Zainal , Nurhasanah Nurhasanah
Published: April 2024

The government gives freedom to each region to regulate its own government affairs, including the distribution of development funds with the aim of maintaining the continuity of government and improving the quality of public services. The allocation of capital expenditures related to adequate maintenance expenditures is very important to maintain the state of government assets so that they can function properly. Every year, various government work units have budgeted the allocation. However, the allocated budget is sometimes too large, resulting in excess funds and cannot be maximized for other priority expenditures. The purpose of this study is to determine the effect of Fixed Assets partially on Maintenance Expenditure. The research method is basically a scientific way to obtain data with certain purposes and uses.” The type of research used in this research is quantitative method. Quantitative research methods can be defined as research methods based on the philosophy of positivism, used to examine certain populations or samples, data collection using research instruments, statistical quantitative data analysis, with the aim of testing hypotheses that have been determined. In accordance with the provisions of the Decree of the Minister of Finance of the Republic of Indonesia Number 01/KM.12/2001 concerning Guidelines for Capitalization of State Owned Assets in the Government Accounting System as regulated again through Minister of Finance Regulation Number 181/PMK.06/2016 concerning Administration of State Owned Goods, the condition of fixed assets is grouped into good, lightly damaged and heavily damaged. Conclusion: Partially Fixed Asset Value (X1) has no effect and is not significant on Maintenance Expenditure (Y) in the Regency/City of South Sumatra Province. Regional Original Income (X2) has no effect and is not significant on Maintenance Expenditures in the Regency/City of South Sumatra Province.
COMPENSATION AND WORK ENVIRONMENT ON THE PERFORMANCE OF NON-MEDICAL EMPLOYEES WITH WORK DISCIPLINE AS INTERVENING VARIABLES IN HOSPITAL X BANDUNG CITY
Authors: Kartina Apriani , Mutiara Rina , Wekadigunawan CRI Sajjna Prajna
Published: April 2024

Hospital X, namely, some employees are still in and out of work, this can be seen from the turnover in the last 3 (three) years and attendance data contained in the HRD section of RS.X.data Turn over for the last 3 (three) years, namely: in 2017 there were 36 employees, in 2018 there were 24 people, and in 2019 there were 30 people. The turnover is very high every year because the average per year is 30% (thirty percent) In this case the researcher wants to highlight three factors that affect employee performance, namely compensation factors, work environment, and work discipline. This selection is based on the fact that these two factors most often appear in theories that discuss the factors that influence employee performance. The purpose of this study was to analyze the effect of compensation and work environment on work quality with performance as an intervening on non-medical employees of RS.X in Bandung. Methods This research uses the type and design of quantitative research, which was conducted on 80 employees. The results of the study that compensation has an influence on work discipline in Non-Medical Employees of Hospital X in Bandung City, the work environment has an influence on work discipline on Non-Medical Employees of Hospital X in Bandung City, compensation has an influence on employee performance on Non-Medical Employees of Hospital X in Bandung. Bandung City, the work environment has an influence on employee performance at Non Medical Employees Hospital X in Bandung City, work discipline has an influence on employee performance at Non Medical Employees Hospital X in Bandung City, compensation has an influence on employee performance with work discipline as a mediating variable (intervening) on ??Non-Medical Employees of Hospital X in Bandung City, and the work environment has an influence on employee performance with work discipline as a mediating variable (intervening) on ??Non-Medical Employees of Hospital X in Bandung City.
THE EFFECT OF STRATEGIC ORIENTATION, TRANSFORMATIVE INTERACTION CAPABILITY, TECHNOLOGY INFORMATION AND TASK IMPLEMENTATION QUALITY ON TEAMWORK PERFORMANCE
Authors: Rohmah Tanzilal Azizi , Qamari Ika Nurul , RDA Meika Kurnia Puji
Published: April 2024

This study aims to examine empirical evidence about the relationship between strategic orientation, transformative interaction capability, information technology and task implementation quality on teamwork performance in high school in Pringsewu district, Lampung. This study uses a quantitative research approach to investigate the relationship between strategic orientation, transformative interaction capability, information technology and task implementation quality on teamwork performance. To achieve the research objectives, data were collected from stakeholders from several high schools in Pringsewu district, Lampung, Indonesia. Using structural equation modeling, and after a series of exploration and confirmation factors were analyzed, the authors tested an integrated model of the relationship between strategic orientation, transformative interaction capability, technology information and task implementation quality on teamwork performance. The results of this study indicate that strategic orientation has a positive and significant effect on teamwork performance. transformative interaction capability has a positive and significant effect on teamwork performance. task implementation quality has no significant effect on teamwork performance. and information technology have a positive and significant effect on teamwork performance
MGA KWENTONG PAMBATANG RADIKAL (RADICAL CHILDREN’S STORIES): EXPLORING SOCIAL THEMES IN CONTEMPORARY CHILDREN’S LITERATURE
Authors: Angoluan Krisha Camille , Guerrero Jarroh Kleigh
Published: April 2024

For thousands of generations, children’s literature has been one of the most powerful tools in providing moral values to children. It employs a subtle technique commonly used to entertain children and at the same time, educate them about rights and wrongs. This kind of literature used human and animal characters usually with a touch of magic which was designed to give entertainment and feed lore to the kids. This study aimed to explore Children’s Literature to examine the issues of its content. The researcher also determined the reasons of the two authors in writing such stories and the perceptions of the parents regarding these kinds of children’s stories. Therewith, the selected five (5) children’s books were first summarized and analyzed. Meanwhile, in both interviews done with the authors and parents, the researcher used a Key Informant and Personal Interview. Ten (10) parents were selected through identifying the age of their child (aged seven (7) and below). The researcher identified the social issues embedded in the children’s stories such as drug, liquor, cigarette, and gambling addiction and illness. Social issues such as this are atypical in children’s literature and this research wanted to determine whether it could help in teaching children’s literature.
Hurwitz moduli varieties parameterizing Galois covers of an algebraic curve
Authors: Kanev Vassil
Published: April 2024

Given a smooth, projective curve \(Y\), a finite group \(G\) and a positive integer $n$ we study smooth, proper families \(X\to Y\times S\to S\) of Galois covers of \(Y\) with Galois group isomorphic to $G$ branched in \(n\) points, parameterized by algebraic varieties \(S\). When \(G\) is with trivial center we prove that the Hurwitz space \(H^G_n(Y)\) is a fine moduli variety for this moduli problem and construct explicitly the universal family. For arbitrary \(G\) we prove that \(H^G_n(Y)\) is a coarse moduli variety. For families of pointed Galois covers of \((Y,y_0)\) we prove that the Hurwitz space \(H^G_n(Y,y_0)\) is a fine moduli variety, and construct explicitly the universal family, for arbitrary group \(G\). We use classical tools of algebraic topology and of complex algebraic geometry.
Revolucionando o ensino fundamental II com metodologias ativas
Authors: De Almeida Amanda Barbosa , Rabelo Carlos Eduardo , Azevedo Celine Maria de Sousa , Vilalva Ester Aparecida de Mei Mello , Pereira Filomena Alves , Kussler Leonora Patricia , Lisboa Maria Iraelma Santana , Sousa Roseline Martins Sabião
Published: April 2024

Este estudo abordou o problema da necessidade de inovação no Ensino Fundamental II, com o objetivo de investigar como a implementação de metodologias ativas pode transformar o processo educacional. A metodologia adotada foi a revisão de literatura, focando em trabalhos que discutem a aplicação de metodologias ativas, como aprendizagem baseada em projetos, ensino híbrido, e sala de aula invertida, e seus impactos na educação. Os resultados indicaram que essas abordagens pedagógicas aumentam significativamente o engajamento e a motivação dos alunos, além de promover o desenvolvimento de habilidades críticas, colaborativas e de pensamento criativo. No entanto, a implementação dessas metodologias enfrenta desafios como a necessidade de formação docente e resistência cultural à mudança. As considerações finais destacam a importância de superar esses desafios para aproveitar os benefícios das metodologias ativas no desenvolvimento acadêmico e pessoal dos alunos.
Avaliação antibacteriana e da toxicidade de ácidos graxos ciclopropenóidicos de extratos das sementes de Pachira aquatica Aublet
Authors: Oliveira Dalglish Gomes de , Santos Lorivaldo Silva , Bezerra Felipe Augusto da Silva , Viana Jessica de Souza
Published: April 2024

Pachira aquatica Aublet da Família Bombacaceae (Malvaceae) é uma espécie conhecida na Amazônia brasileira como Mamorana. As sementes de mamorana, também conhecidas como nozes, são ricas em ácidos graxos, óleos, proteínas, carboidratos e lipídios. O trabalho teve como objetivo quantificar as substâncias presentes nos extratos das sementes de P. aquatica, bem como avaliar a ação antimicrobiana e a toxicidade frente à Artemia salina dos extratos das sementes. As sementes foram submetidas extrações à quente e à frio com acetona: extrato bruto acetônico à quente (EBA – Q) e extrato bruto acetônico à frio (EBA – F). No EBA – F foi identificado em quantidades significativas por ressonância magnética nuclear (RMN) e cromatografia gasosa acoplada a espectrômetro de massa (CG – EM) a presença do ácido graxo estercúlico. Enquanto no EBA – Q não foram identificadas a presença de ácidos graxos ciclopropenóides. O bioensaio com Artemia salina apresentou toxidade no EBA – F com concentração letal (CL50) de 107,15 µg/mL, sendo promissor para futuros estudos de bioatividade e atividades farmacológicas. Já no EBA – Q a CL50 foi de 2712,27 µg/mL, sendo considerado atóxico. Os extratos EBA – Q e EBA – F foram submetidos a ensaio antimicrobiano, porém não apresentaram nenhuma atividade nas bactérias testadas.
Tecnologias educacionais para mulheres com diabetes gestacional na atenção primária: uma revisão de escopo
Authors: Medeiros Vitor Araújo de , Alves Valdecyr Herdy , Vieira Bianca Dargam Gomes , Calandrini Tatiana do Socorro dos Santos
Published: April 2024

Introdução: as tecnologias educacionais constituem recursos essenciais para potencializar as intervenções no contexto do diabetes gestacional na atenção básica, permitindo que as gestantes assumam um papel mais ativo e autônomo na gestão de sua saúde. Objetivo: mapear as tecnologias educacionais ofertadas para mulheres com diabetes gestacional na Atenção Primária à Saúde (APS). Método: revisão de escopo, atendendo à metodologia do JBI Manual for Evidence Synthesis e checklist do Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (Prisma-ScR), com a seguinte pergunta: quais são as tecnologias educacionais ofertadas para mulheres com diabetes gestacional na Atenção Primária à Saúde? A busca foi realizada nas bases de dados Biblioteca Virtual em Saúde, Web of Science e Scopus. Os estudos serão agrupados no software Rayyan e as duplicatas, removidas. As citações selecionadas foram avaliadas, seguindo os critérios de inclusão, por dois revisores independentes. Resultados: a busca resultou em oito estudos elegíveis para compor a revisão, evidenciando a ausência de produções brasileiras e latino-americanas e do uso de ferramentas digitais. Demonstrou-se a importância dessas ferramentas para o monitoramento da doença e uma preocupação subjacente relacionada à proteção dos dados e à alfabetização digital dos usuários. Conclusão: nota-se que as tecnologias educacionais para o tratamento do diabetes gestacional ainda são pouco exploradas, sendo necessárias futuras intervenções, visando aprimorar práticas clínicas e estratégias de educação e suporte para esse grupo específico de pacientes.
Avaliação da qualidade de cápsulas de valeriana produzidas em farmácias magistrais do município de Maringá (PR)
Authors: Freire Laura Souza , Gancedo Naiara Cássia , Mello João Carlos Palazzo de , Dutra Rita de Cássia , Isolani Raquel , Teston Ana Paula Margioto , Chierrito Danielly , Araújo Daniela Cristina de Medeiros
Published: April 2024

Este estudo visou avaliar a qualidade de cápsulas de valeriana 120 mg produzidas e comercializadas em cinco farmácias magistrais em Maringá, Brasil, por meio de testes abrangentes de controle de qualidade. As cápsulas foram submetidas a uma série de testes, incluindo peso médio, desintegração, solubilidade, análise das características organolépticas, determinação do pH e identificação de compostos fenólicos e alcaloides. Resultados: As cinco amostras demonstraram homogeneidade no conteúdo distribuído e se desintegraram dentro dos limites aceitáveis. As amostras 1, 2, 4 e 5 apresentaram solubilidade parcial, enquanto a amostra 3 foi levemente solúvel. As cápsulas exibiram características organolépticas consistentes, como cor que varia de castanho claro a escuro, textura de pó fino e odor característico. O pH das amostras variou de 5,1 a 6,1. Todas as amostras apresentaram resultados positivos para compostos fenólicos e alcaloides, exceto a amostra 3, que foi negativa para compostos fenólicos. Os testes conduzidos corroboraram a importância do controle de qualidade das cápsulas de valeriana 120 mg. Além disso, destacaram a praticidade e acessibilidade desses testes para as farmácias magistrais.