bluuebunny/crossref_metadata_2025 huggingface dataset:
SÍNDROME DE DUNNIGAN OU LIPODISTROFIA FAMILIAR TIPO 2 (LPF2) RELATO DE DOIS CASOS
Authors: Mazoti Saturi Flávia , Ferrari dos Santos Thalita , Engler Ana Paula , Alonso Frederico , Guidorizzi Nathália
Published: August 2024

A Síndrome de Dunnigan, ou Lipodistrofia Parcial Familiar Tipo 2 (LPF2), é uma doença genética rara que provoca a perda seletiva e progressiva de tecido adiposo subcutâneo, geralmente após a puberdade. O tecido adiposo, um importante órgão endócrino, regula a homeostase energética, o metabolismo lipídico e hormonal, estando associado a várias condições metabólicas como obesidade, diabetes mellitus tipo 2 (DM2) lipodistrofias e doenças cardiovasculares. A lipodistrofia é classificada como congênita e adquirida de acordo com a sua origem, e generalizada e parcial, conforme seu acometimento corporal. (LEÃO et al., 2011). A LPF2 é uma condição rara, com uma prevalência global estimada de 1 em cada 10 milhões de pessoas. A literatura aponta diferentes taxas de prevalência em diversos países. Nos Estados Unidos e na Noruega, a prevalência é de 1 em 10 milhões e 1 em 1 milhão de pessoas, respectivamente. No Brasil, a maior prevalência é observada no estado do Rio Grande do Norte, no Nordeste. Com uma proporção de 1 em 28 mil pessoas. Pesquisas genealógicas sobre as famílias que colonizaram essa região sugerem que a alta prevalência da lipodistrofia congênita está relacionada à origem portuguesa, além da grande quantidade de casamentos consanguíneos na região (BISPO & FREITAS, 2023). Este trabalho, por meio do relato de dois casos clínicos, objetiva compreender os aspectos clínicos, genéticos e psicossociais da LPF2 destacando suas manifestações, diagnóstico e opções terapêuticas.
SÍNDROME DA REALIMENTAÇÃO UMA BREVE REVISÃO DA FISIOPATOLOGIA AO TRATAMENTO NUTRICIONAL
Authors: Silva Nádia , Souza Carolina , Oliveira Antonio , Morais Débora , Silva Agnes , Ferreira Lucas , Neto Vanessa , Santos Jéssica , Santos Natalia , Araújo Maria , Freitas Laura
Published: August 2024

The aim of this study is to address the Refeeding Syndrome, a brief review of pathophysiology to nutritional treatment. The refeeding syndrome can be said in short that changes in metabolism, cardiac, nervous and neurological systems occur. Food reintroduction in patients with risk factors for developing refeeding syndrome should be performed cautiously and gradually. Monitoring of metabolic parameters and electrolyte levels before initiation and during support of nutritional therapy should be performed routinely and based on recommendations. The nutrition team is important to guide and educate other health professionals in order to emphasize the importance of paying attention to patients at risk of developing the syndrome.
VULNERABILITY OF POLICE OFFICERS TO SEXUALLY TRANSMITTED INFECTIONS: PROTOCOL FOR SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: dos Reis Meillyne Alves , Ferreira Laís Bárbara , Biella Ana Flávia de Carvalho Lima , Pereira Ana Claudia Souza , de Matos Marcos André
Published: August 2024

Introduction: Sexually transmitted infections (STIs) are a serious global public health problem, given the impact on the sexual and reproductive health of infected individuals and their partners. Therefore, this systematic review and meta-analysis is aimed to describe the vulnerability of police officers to STIs, as well as the associated factors.
A INFLUÊNCIA DO MÉTODO PILATES SOBRE A MUSCULATURA RESPIRATÓRIA EM PESSOAS IDOSAS: UMA REVISÃO INTEGRATIVA.
Authors: Rosa Yasmim Pereira de Ávila , Marcelino Gustavo Carvalho , Lemes Uitairany do Prado , Toledo Elizeu de Araújo , Rosa Yanna Pereira de Ávila
Published: August 2024

INTRODUÇÃO: Com o envelhecimento podem ser observadas alterações na quantidade e composição dos componentes do tecido pulmonar, o que levam a complacência torácica e pulmonar diminuída, fazendo com que a tensão e o comprimento do diafragma anulam a força muscular e alteração postural. Uma boa opção de atividade física a ser desempenhada pela população idosa, é o método Pilates, que se baseia em seis princípios: concentração, controle, precisão, centro, respiração e fluidez. OBJETIVO: analisar na literatura a influência do método Pilates na musculatura respiratória de pessoas idosas. METODOLOGIA: Trata-se de uma revisão integrativa de literatura, construída a partir das seguintes bases de dados: PubMed, SciELO, Cochrane Library e LILACS, através dos descritores obtidos pelo DeCS/MeSH: Método Pilates; Idosos; Músculos respiratórios, encontrando 10 artigos para discussão. RESULTADOS/DISCUSSÃO: O método Pilates, é uma ferramenta terapêutica que traz benefícios na capacidade pulmonar da pessoa idosa, melhorando aspectos como, força e resistência respiratória, mobilidade toracoabdominal e qualidade de vida. CONCLUSÃO: Baseando-se nos achados dos estudos listados na discussão, nota-se que o método Pilates mostra-se como uma possibilidade terapêutica eficaz em relação aos parâmetros respiratórios da pessoa idosa. Porém, os achados encontrados ainda se mostram limitados, sendo necessário que mais estudos sejam realizados para obter uma maior comprovação e maiores evidências sobre o tema apresentado.
Navigating heterogeneity in meta-analysis: methods for identification and management
Authors: Ilmawan Muhammad
Published: August 2024

Although meta-analysis is a powerful way to synthesize research findings from multiple studies, the problem of heterogeneity usually arises due to variation in study outcomes. Differences between studies regarding heterogeneity in results can arise from populations, interventions, outcome measures, and methodologies both within and between the studies. This article aims to provide an overview of the methods for identifying and dealing with heterogeneity in meta-analyses to ensure accurate and reliable conclusions. The article aims to describe the application of several statistical methods for detecting heterogeneity, namely the Q statistic and the I² statistic. The Q statistic is used to test whether observed variability in effect sizes exceeds chance expectations, while the I² statistic quantifies the proportion of variability due to heterogeneity. Other methods include the DerSimonian-Laird between-studies variance in random-effects models and the T and T² methods, which use both observed and expected information about effect size dispersion. Methods for dealing with heterogeneity are discussed, including choices between using fixed- versus random-effects models, and techniques for assessing and dealing with outliers using methods such as the Hedges technique. Additionally, the article explores methods to investigate sources of heterogeneity through subgroup analysis and meta-regression. Recognizing limitations such as residual heterogeneity, publication bias, and study quality is also important in making meta-analytical findings more robust. In conclusion, these methods enable researchers to more effectively address heterogeneity issues in meta-analyses, thereby providing more reliable and valid conclusions that contribute to evidence-based practice
Exploring a rare oncologic complication: alveolar rhabdomyosarcoma in HIV patient
Authors: Santoso Dimas , Santoso Budi , Kristyana Septian , Candradikusuma Didi , Natasia Septalisa , Evatta Arde
Published: August 2024

BACKGROUND: Alveolar rhabdomyosarcoma is one of the rare oncological complications in Human Immunodeficiency Virus (HIV) patients, but it has a serious impact. Therefore, case report study discussing case of alveolar rhabdomyosarcoma in HIV patient is very important.
CASE: A 22-year-old man complained of pain and a growing lump behind his right knee for 9 months. The lump, initially small, became larger and more painful, affecting his ability to move his leg. The patient was diagnosed with HIV 3 years ago and also had leprosy. Additionally, the patient had a history of weight loss and a low body mass index (BMI). Physical examination revealed a 10x15x10 cm mass behind the right knee. Magnetic Resonance Imaging (MRI) of the right knee showed a complex cystic solid lesion involving several muscles and blood vessels. Fine Needle Aspiration Biopsy (FNAB) suggested a High-Grade Sarcoma. Open biopsy confirmed alveolar rhabdomyosarcoma with aggressive features and high mitotic activity.
CONCLUSION: In conclusion, our study reported the first case of alveolar rhabdomyosarcoma in an HIV patient. Our study emphasizes the importance of thorough diagnosis for suspected malignancies in HIV patients.
PENERAPAN METODE CIRC DALAM PENINGKATAN KEMAMPUAN MENULIS KREATIF SISWA KELAS VIII-G SMP NEGERI 2 NGANJUK SEMESTER GANJIL TAHUN PELAJARAN 2018/2019
Authors: Kurniawati Lustina
Published: August 2024

Kegiatan berbahasa sehari – hari mencakup empat aspek, antara lain keterampilan mendengarkan, keterampilan berbicara, keterampilan membaca, dan keterampilan menulis. Dari keempat keterampilan diatas, penulis kali ini akan meneliti keterampilan menulis yang akan dilaksanakan oleh siswa kelas VIII-G di SMP Negeri 2 Nganjuk pada semester ganjil tahun pelajaran 2018/2019. Dari data penelitian nilai rata – rata keterampilan menulis selalu menunjukkan angka dibawah KKM yang telah ditetapkan. Atas dasar kondisi inilah maka penulis mengadakan penelitian tindakan kelas dengan menerapkan CIRC (Cooperative Integrated Reading and Composition) sebagai metode dalam proses pembelajaran menulis kreatif pada siswa SMP Negeri 2 Nganjuk, khususnya kelas VIII-G, dengan fokus penelitian meningkatkan kemampuan menulis kreatif naskah drama melalui metode CIRC. Berdasarkan hasil penelitian tindakan kelas, dapat disimpulkan bahwa metode CIRC dapat digunakan untuk meningkatkan kemampuan menulis kreatif siswa kelas VIII-G di SMP Negeri 2 Nganjuk pada semster ganjil tahun pelajaran 2018/2019. Hal ini dapat dilihat dari hasil obsevasi kemampuan siswa dalam menulis kreatif yang sebelum penerapan metode CIRC hanya memperoleh kategori kurang, tetapi setelah penerapan metode CIRC memperoleh kategori baik. Disamping itu, dalam pembelajaran dengan menggunakan metode CIRC, sebagian besar siswa merespon sangat positif dalam proses kegiatannya, kinerja gurupun semakin baik. Penerapan metode CIRC pada mata pelajaran Bahasa Indonesia materi menulis kreatif naskah drama telah berhasil memperoleh skor maksimal.
PERAN LITERASI KEUANGAN DAN PENDIDIKAN EKONOMI DALAM KELUARGA TERHADAP PERILAKU KONSUMTIF MAHASISWA
Authors: Ramadhan Fahmi Putra Hanif
Published: August 2024

Artikel ini bertujuan untuk mengetahui peran literasi keuangan dan pendidikan ekonomi dalam lingkungan keluarga yang didapatkan oleh individu terhadap perilaku konsumtif mahasiswa ditengah pesatnya perkembangan era digitalisasi yang membuat transaksi ekonomi semakin mudah dan praktis untuk dilakukan. Metode yang digunakan dalam pembuatan artikel ini adalah literature review yang mana uraian tentang teori dan temuan dari penelitian yang telah ada digunakan sebagai bahan acuan dalam menyusun artikel ini. Hasil dari penelitian ini menunjukkan pendidikan ekonomi dalam keluarga mempunyai peran yang sangat penting terhadap perilaku konsumtif mahasiswa, semakin tinggi intensitas peran orang tua dalam memberikan pendidikan ekonomi di keluarga maka semakin baik pula pola pikir mahasiswa dalam mengontrol perilaku konsumtif di dalam kehidupannya, selain itu literasi keuangan yang bagus juga bisa berperan untuk mengontrol perilaku konsumtif dengan baik. Pentingnya literasi keuangan akan meminimalisir perilaku konsumtif mahasiswa dalam berkonsumsi jika mahasiswa menerapkan teori-teri ekonomi dalam kehidupan sehari-hari.
Clinical assessment of glycated hemoglobin in diabetic hypothyroid patients: A comparison with Euthyroid non diabetic subjects
Authors: Hasan Ali Mohammad
Published: August 2024

Background: Thyroid disease and diabetes mellitus (DM) are the two most common heterogeneous endocrine disorders in the general population. Both hypothyroidism and type 2 DM are closely involved in cellular metabolism and affect the malfunction of various organ systems. HbA1c was studied for its correlation with thyroid hormones and used for screening, diagnosis, and control of glycemic status.
Objective: To evaluate the validity of HbA1c as a screening and useful test to diagnose hypothyroid patients with pre-diabetes and diabetes.
Methods: The current study was conducted in the Specialized Center for Endocrinology and Diabetes/Baghdad, Iraq from October 2021 to May 2022. The present study was carried out on 115 hypothyroidism patients (92 females and 23 males), and one hundred individuals with normal thyroid function were chosen as a control group. Each patient and individual was investigated for thyroid profile using Vitek immunodiagnostic assay system (VIDAS), while HbA1c was assessed on whole blood by automated chemistry analysis (Analyticom).
 Results: The results showed that most hypothyroid patients were within the age group (24-70) years, which represented 20% ≤(30), 32.2% ≤(40), and 28.7% ≤(50) years. Most hypothyroidism patients were females constituting 80% compared with 20% for males. Most hypothyroidism patients were obese BMI≥30Kg/m² represented 42.7% and overweight     ≥ 25Kg/m² represented 40% compared with 15.7 who were normal weight. The prevalence of diabetes mellitus represented more than two times among the hypothyroidism individuals compared with the control sample, which indicated a highly significant relationship at  Pvalue<0.01. The results also showed that meaningful significant differences were revealed between the two independent groups with highly significant differences at Pvalue<0.01 within the following parameters (HbA1c, Glucose, Thyroid stimulating hormones (TSH), Thyroxine (TT4), Triiodothyronine (TT3).
Conclusion: The present study conclude that the frequency of diabetic patients was significantly increased in hypothyroid population when compared with general population. The use of HbA1c for screening and supported diagnosis assay is necessary to detect and control diabetic patients.
Analisis Ayat Al-Qur’an Dan Hadist Tentang Kurikulum Manajemen Pendidikan Islam
Authors: Wasti Purna Wirawan , Siti Nur Afifah  , Nur Laili Komairatul Fitria  , Mahrus  , Agus Sudrajat
Published: August 2024

Kurikulum pendidikan islam menempati posisi utama dalam kemajuan sumber daya manusia, sehingga manajemen kurikulum Pendidikan islam menjadi hal penting dalam memajuakan Pendidikan islam secara keseluruhan. Penelitian ini menggunakan jenis penelitian library research atau kajian pustaka. Adapun tujuan yang ingin dicapai dari penelitian ini yaitu: Untuk Mendeskripsikan Kurikulum Manajemen Pendidikan Islam, Untuk Mendeskripsikan Fungsi dan Tujuan Kurikulum, Untuk Menganalisis Ayat Al-qur’an dan hadits tentang Kurikulum Manajemen Pendidikan Islam. Kurikulum adalah seperangkat rencana yang menggambarkan kumpulan mata pelajaran, tujuan, isi, yang harus ditempuh oleh peserta didik sebagai pedoman dalam kegiatan mengajar untuk mencapai Pendidikan tertentu. Fungsi kurikulum adalah Fungsi Penyesuaian, Fungsi Integrasi, Fungsi Diferensiasi, Fungsi Persiapan, Fungsi Pemilihan, Fungsi Diagnostik. Tujuan memberikan pegangan mengenai apa yang harus dilakukan, bagaimana cara melakukannya, dan merupakan patokan untuk mengetahui sampai dimana tujuan itu telah dicapai. Memegang peranan sangat penting, akan mewarnai komponen-komponen lainnya dan akan mengarahkan semua kegiatan mengajar. Kurikulum yang dirumuskan menggambarkan pula pandangan para pengembang kurikulum mengenai pengetahuan, kemampuan, serta sikap yang ingin dikembangkan. Dalam Al qur’an dan hadits ditemukan kerangka dasar yang dapat di jadikan sebagai pedoman operasional dalam penyusunan dan pengembangan kurikulum pendidikan Islam, kerangka dasar tersebut adalah, Tauhid, dan Perintah membaca.
Pengembangan Metode Pembelajaran PAI dengan Pendekatan ‎Teori Pemrosesan Imformasi dan Teori Neuroscience
Authors: Reti Suryani  , Zuhriyah Indah Aminatuz
Published: August 2024

This study aims to examine students' thinking and describe students' way of thinking in receiving information and storing information and processing information in Islamic Religious Education subjects with Islamic Religious Education learning development methods. This research uses a qualitative approach. This research aims to assist educators in providing learning in the classroom to make it easier for educators to solve complex problems in PAI learning.
Strategi Pembelajaran Bahasa Arab untuk Meningkatkan Keterampilan Membaca di Era Digital
Authors: Isnaini Maulidya , Umar Mohammad
Published: August 2024

Penelitian ini dilatarbelakangi oleh banyaknya siswa yang kesulitan dalam menyerap dan memahami bacaan yang dibacanya dalam pembelajaran bahasa Arab. Maka diperlukan strategi pembelajaran yang baik dan tepat agar dapat menghasilkan pembelajaran yang maksimal dalam meningkatkan kualitas pembelajaran bahasa Arab, salah satunya adalah keterampilan membaca. Tujuan dari penelitian ini adalah untuk mengetahui apa saja strategi pembelajaran berbasis keterampilan membaca bahasa Arab dan apa saja strategi membaca yang efektif. Metode penelitian yang digunakan dalam penelitian ini adalah pendekatan deskriptif kualitatif, jenis penelitian pustaka. Hasil penelitian menunjukkan bahwa terdapat beberapa strategi pembelajaran berbasis keterampilan membaca bahasa Arab, yaitu: 1) Qira'ah muwajahah mempelajari teks dengan bagan atau skema. 2) Mudzakarat al-Talamidz untuk meningkatkan keaktifan dan keberanian siswa. 3) Qira'ah jahriyyah untuk membantu siswa menyajikan pemahaman. 4) Akhziyat al-Nash untuk mendorong siswa aktif belajar. 5) Talkhis Jama'i berbicara untuk membantu siswa berinteraksi satu sama lain dalam mengungkapkan gagasannya. 6) Tartib al-Nash untuk mengetahui kemampuan membaca siswa. Terdapat beberapa strategi membaca yang efektif, yaitu: 1) Garis Besar Kosong untuk melatih kemampuan siswa dalam mengungkapkan isi bacaannya ke dalam bentuk tabel. 2) Analisis untuk melatih siswa memahami isi bacaan dengan menemukan gagasan pokok dan gagasan pendukung. 3) Snow Bolling untuk mendapat banyak masukan dari teman. 4) Broken Square/Teks untuk menyusun kembali bacaan yang telah dipotong sebelumnya. 5) Index Card Match untuk mengajarkan kata atau kalimat bersama pasangan.
Rights of Women: National and International Perspective
Authors: Pandey Shivangi R , Satyam Sourabh
Published: August 2024

The paper explores India's complex relationship with women's rights, highlighting the significant role women play in society and the various contributions they make. Despite being half of the world's population, women still face discrimination, violence, and gender prejudice. The article discusses the development of women's rights over time, focusing on issues like healthcare, equality, employment, and political engagement. It highlights the legal and constitutional framework, as well as global accords, that support gender equality and defend women's rights. The article also discusses the Indian Constitution's clauses and laws regarding harassment at work, maternity benefits, and discrimination. The article concludes by acknowledging the improvements in women's rights but also emphasizes the ongoing challenges they face, particularly in terms of safety and security. Lastly, this article provides a thorough examination of women's rights in India, including both the legal system and the difficulties women face in everyday life.
Learning of Renewable Energy Sources in Elementary School Based on Digital
Authors: Rohman Abdul , Nandiyanto Asep Bayu Dani
Published: August 2024

The purpose of this study was to analyze the understanding and knowledge of energy sources from the definition, types and benefits of using digital-based learning methods. This research was conducted on grade elementary school students in the city of Pandeglang, Indonesia using 20 question questionnaires as the object of assessment, the questionnaire was distributed at the first meeting and continued with material at the next meeting then at the final meeting the students would fill out the questionnaire again. The same as the evaluation material. The question questionnaire was distributed through social media such as whatsapp and manually using writing paper. These results indicate that the scores obtained by the students showed an increase. This proves that the students already know the basic material that has been given and understand the material that has been taught at the previous meeting. The material taught about renewable energy sources is the meaning of renewable energy, types of renewable energy, the use of renewable energy and how to save energy. The main reason for the success in this research is that the material is given to students using powerpoint media which is packaged in an attractive way so that students are enthusiastic about learning, besides that, each meeting will be filled with discussion sessions and activities to watch learning videos obtained through YouTube media which aims to to increase students’ knowledge about renewable energy sources. With this learning method, students are more enthusiastic in doing learning as evidenced by students who are actively answering the questions that have been asked.
Effect of Heat Moisture Treatment (HMT) Duration and Lactic Acid Concentration on the Characteristics of Purple Sweet Potato Flour (Ipomoea batatas L. Poiret)
Authors: Nurminabari Ina Siti , Gozali Thomas , Ikrawan Yusep , Hariadi Hari , Eriningtyas Fanisa
Published: August 2024

This study aims to determine the effect of heat moisture treatment (HMT) duration and lactic acid concentration on the characteristics of purple sweet potato flour (Ipomoea batatas L. Poiret). The method consisted of two stages, namely preliminary stage to produce control (unmodified) flour and main stage to produce modified flour. The method used was a randomized group design with a factorial pattern of 3 x 3 and 3 replications. The variables used were HMT duration (3, 5, and 7 hours) and lactic acid concentration (200, 400, and 600 ppm). The parameters observed in the main stage were water content, anthocyanin level, swelling power, color, solubility, and flour gelatinization profile or Rapid Visco Analysis (RVA). The results show that HMT duration affected the water content and solubility of the modified purple sweet potato flour. HMT duration of 7 hours and lactic acid concentration of 600 ppm resulted in flour anthocyanin level of 24.046 mg/kg. The gelatinization profile shows that the modified purple sweet potato flour experienced the initial temperature of gelatinization (pasting temperature) at 92.30ºC, peak viscosity at 1,343 cP, hot paste viscosity (hold viscosity) at 362 cP, cold paste viscosity (final viscosity) at 931 cP, breakdown (viscosity stability during heating) at 381 cP, and seatback (changes in viscosity during cooling) at -31 CP.
Urban Violence and Criminality: a Socio-Ethnographic Study
Authors: BELGHIT Mohammed Tayeb
Published: August 2024

Urban violence refers to any form of violence occurring in cities and suburbs. It may involve delinquent acts such as theft, physical assault, harassment, vandalism, etc. This article aims to provide a scientific explanation for the violent behavior and practices of young people. The observations and analyses conducted in this case study will seek, through an ethnographic approach, to go beyond the collected data in order to identify this new reality currently experienced in cities, especially in overcrowded neighborhoods, and to determine the factors contributing to the spread of this urban violence phenomenon in our towns and villages. Urban violence is a complex phenomenon that can have serious and lasting consequences on the affected individuals, families, and communities, in addition to being influenced by a variety of factors, including social inequalities, economic factors, and peer group dynamics.
EFEITOS DO TREINAMENTO FÍSICO PARA IDOSOS COM DIABETES MELLITUS TIPO 2
Authors: Almeida Souza Matheus , De Castro Daher Isabella , Campos Costa Letícia , Mota Sales Milena , De Almeida Santos Nathalia , Gomes Neves Luis Henrique , Duarte Toledo Martins Anaile
Published: August 2024

A Diabetes Mellitus tipo 2 é uma doença crônica que ocorre devido ao aumento dos níveis de glicose no sangue, caracterizado pela hiperglicemia perpetuada. Objetivou-se realizar o levantamento dos efeitos e benefícios dos exercícios físicos em idosos com diabetes mellitus tipo 2. Trata-se de uma revisão bibliográfica, com busca de estudos nas seguintes plataformas: PubMed, Scielo e Lilacs, pesquisados a partir de descritores em saúde e conectados por operadores booleanos. Foram incluídos estudos publicados a partir de 2012. Os resultados demonstraram que o exercício físico, seja ele exercício resistido, exercício aeróbico ou a combinação dos mesmos pode trazer benefícios e podem ser aplicados como tratamento para esta doença, como controle glicêmico, efeito hipotensor, ganho de força e melhoria da tolerância ao exercício físico.
USO DE PROBIÓTICOS ASSOCIADOS À COSMÉTICOS NO TRATAMENTO DA DERMATITE ATÓPICA
Authors: Cremasco Medeiros Aléxia , Alves Oliveira Ketely Priscila , De Melo Oliveira Lívia Cristina , Souza Maria Eduarda , Souza de Sá Godinho Alexandra , Pereira Lima Godinho Karine , Da Silva Altera Daniele , Gonçalves Soyer Tauane
Published: August 2024

Atualmente, há um interesse crescente na composição do microbioma da pele, tanto em indivíduos saudáveis quanto em pessoas com doenças cutâneas, como a Dermatite Atópica. O objetivo deste estudo é descrever a eficácia do uso  de probióticos associados à cosmetologia no tratamento de doenças dermatológicas, como a Dermatite Atópica.Realizou-se uma revisão narrativa utilizando as bases de dados Google Scholar e PubMed, abrangendo artigos científicos completos publicados entre 2013 e 2023, em português ou inglês. Os descritores utilizados na busca foram: Cosméticos, Probióticos, Inovações, Dermatite, e Microbioma, em ambos os idiomas. Após a seleção dos artigos, em momentos distintos e conforme critérios de elegibilidade previamente definidos, foram utilizados 32 artigos para a redação desta revisão narrativa. A Dermatite Atópica é uma condição inflamatória crônica da pele, tratada com hidratação, controle da inflamação e corticoides tópicos. A utilização de microrganismos probióticos em cosméticos representa uma área de pesquisa em expansão, oferecendo diversas oportunidades comerciais. Este estudo destacou que os probióticos são empregados para tratar diversas condições dermatológicas. Os resultados positivos observados, como a melhoria na hidratação da pele e a redução da colonização por bactérias prejudiciais, sugerem que essa abordagem pode ser uma adição valiosa aos cuidados com a pele. Embora os achados sejam promissores, ainda não podemos afirmar definitivamente sobre a eficácia dos probióticos em cosméticos para Dermatite Atópica.
Alergia à proteína do leite de vaca em crianças: Aspectos clínicos e manejo atual
Authors: Germino Lucas Leal , Sumida Gerson Hisao , Salani Gabriella Ferreiro , Faria Natalia de Matos , Silva Flávia Brito da , Chiavini Mariê Scortegagna , Costa Ana Clara Carmo , Moussa Ahmad Ben , Salani Gabriella Ferreiro
Published: August 2024

A alergia à proteína do leite de vaca (APLV) é uma das alergias alimentares mais comuns em crianças, com manifestações variáveis que podem incluir sintomas gastrointestinais, cutâneos e respiratórios, e em casos graves, anafilaxia. A prevalência de APLV, que afeta cerca de 2% a 3% das crianças menores de três anos, tem mostrado aumento, possivelmente devido a mudanças ambientais e dietéticas. O manejo da APLV envolve a eliminação do leite de vaca da dieta, o que pode ser desafiador devido à presença ampla desse alimento em produtos consumidos diariamente. A reintrodução gradual do leite é realizada por meio de desafios alimentares, monitorados rigorosamente para avaliar a tolerância. Este estudo, uma revisão integrativa da literatura, visa analisar os aspectos clínicos e o manejo atual da APLV em crianças. Utilizou-se a estratégia PICO para formular a questão de pesquisa e foram realizadas buscas em bases de dados como PubMed, Scielo e Lilacs, com foco em artigos dos últimos cinco anos. A revisão incluiu 10 estudos relevantes, que abordam desde o diagnóstico e as manifestações clínicas da APLV até as estratégias terapêuticas e as inovações recentes. Os resultados indicam que, apesar das estratégias atuais de manejo, como a eliminação rigorosa do leite e o uso de fórmulas alternativas, a APLV continua a impactar significativamente a qualidade de vida das crianças e suas famílias. A pesquisa destaca a importância da educação contínua das famílias e a necessidade de abordagens inovadoras e integradas para otimizar o tratamento e melhorar os resultados clínicos.
The Alchemy of Truly Remarkable Leadership: Ordinary, Everyday Actions that Produce Extraordinary Results
Authors: Westover Jonathan
Published: August 2024

Consider how the nature of work has shifted over the past 50 years. With increased globalization, rapid technological advancement, and a shift in economic composition, the average jobs of today look very little like the average jobs 50 years ago. What will the jobs and organizations of tomorrow look like? Moreover, what does this all mean for organizational leaders? What are the core competencies and capabilities of organizations and their leadership that are prepared for continued disruption and geo-political and socio-economic shifts? Increasingly leaders need to be socially-minded, data-driven, decisive, champions of talent, and disruptors of the traditional notions of leadership, teams, organizations, and work. The Alchemy of Truly Remarkable Leadership will help you to explore your own leadership competencies and capabilities and consider ways to apply and implement them into your workplace and personal life.
The Future Leader: Creating & Transforming Next Gen Organizations
Authors: Westover Jonathan
Published: August 2024

Stemming from two decades of professional experience and over 600 in-depth interviews with executives, thought leaders, and scholars from across the globe, The Future Leader will help you explore the ordinary, everyday actions that will help you to prepare to lead in the future of work, to respond to an uncertain future, and to produce extraordinary results for individuals, teams, and organizations.
Developing Leadership for Disruption: Bridging Talent Gaps in Times of Change
Authors: Westover Jonathan
Published: August 2024

This article examines the key challenges facing organizational leadership in developing talent to navigate ongoing business transformation driven by globalization, technological disruption and societal change. Drawing from research on risks perceived by executives and practitioners, such as talent shortages inhibiting growth and untapped value from diverse perspectives, the article explores strategic approaches leaders are taking to bridge divides between their strategic vision and workforce realities. Case studies of organizations implementing leadership competency frameworks, experiential learning opportunities, a culture of continuous learning, and diversity, equity and inclusion programs at the highest levels illustrate how aligning holistic leadership development with changing business needs can foster engaged, diverse talent pipelines capable of addressing complex problems through innovation.
Relationship Between Knowlwdge and Motivation of Diabetic Patients in Compliance with Diabetes Melitus Diet at UPTD Puskesmas Aceh
Authors: Butarbutar Maria Haryanti , Siregar Riani Baiduri , Saputra Heri , Purwana Rudi
Published: August 2024

Diabetes Mellitus is a state of hyperglycemia which is characterized by chronic insulin absolute conditions which can affect carbohydrate metabolism. In 2015 there were 415 million adults with diabetes. The purpose of this study was to analyze the relationship between knowledge and motivation of diabetic patients in adherence to the diabetes mellitus diet at the Aceh Public Health Center. The population in this study were all diabetes mellitus patients who were controlled at the UPTD Puskesmas DTP Lampahan as many as 40 respondents. The sampling technique used is the total population of 40 respondents. The results showed that based on the chi-square test between knowledge of compliance with diabetes mellitus diet obtained p-value = 0.008, motivation with diabetes mellitus obtained p-value = 0.019, motivation with compliance running a diabetes mellitus diet obtained p-value = 0.020, the role of health workers with diabetes mellitus obtained p-value = 0.027. Conclusion Based on the results of the chi-square test, it can be concluded that there is a significant relationship between knowledge, self-motivation and adherence to dieting in people with diabetes mellitus at the UPTD Puskesmas DTP Lampahan.
The Effect of Health Education Programs on Adolescents’ Knowledge and Attitudes regarding Reproductive Health
Authors: Yuniarti Siswari , Yustanta Brivian Florentis , Kowaas Intan Novita , Nurrachmawati Annisa , Rahmawati Sylvina
Published: August 2024

Adolescent reproductive health is an important issue in the field of public health, because adolescents are vulnerable to the risk of reproductive health problems if their knowledge and attitudes towards reproductive health are inadequate. Health education programs have the potential to improve adolescents’ knowledge and attitudes about reproductive health, but there has not been much research that thoroughly explores the impact of these programs. This study aims to evaluate the effect of health education programs on adolescents’ knowledge and attitudes about reproductive health. This research uses a quantitative research method with a pre-test post-test control experimental research design. Data on adolescent knowledge and attitudes about reproductive health were collected using questionnaires before and after the intervention. The results of this study show that after participating in a health education program, adolescents’ knowledge about reproductive health increased compared to not participating in the education program. In addition, there was an increase in teenagers’ positive attitudes towards reproductive health after participating in the educational program. This research also shows that health education programs are effective in increasing teenagers’ knowledge and attitudes about reproductive health. This emphasizes the importance of integrating reproductive health education programs in educational curricula for adolescents to increase their awareness of reproductive health issues and encourage healthy behavior. The conclusion of this research is that health education programs have a positive influence on teenagers’ knowledge and attitudes about reproductive health. This emphasizes the importance of integrating reproductive health education programs in the education curriculum to increase teenagers’ understanding and attitudes towards reproductive health issues. Collaborative efforts between educational institutions, public health and communities are needed to create an environment that supports overall adolescent reproductive health.
Utilization of VN Application as a Learning Media for Social Education at Elementary School Level
Authors: Rohmawaty Evy Nur , Wahyuni Sri , Ginarti Ginarti
Published: August 2024

Background. The downside of distance learning activities is that students lack enthusiasm, which results in disappointment in learning outcomes. The problem is due to the lack of tools and opportunities that are not maximized by educators during learning activities.
Purpose: The purpose of this study is to optimize the performance of VN applications to motivate and improve student comprehension skills in learning natural science at the elementary school level.
Method. The method used in this research includes direct field research which is a research method with a qualitative descriptive approach. Descriptive which describes the condition of students in classroom learning activities and makes the VN application and students as the object of research.  This approach provides a real explanation of how much influence the utilization of the VN application to describe the learning material obtained in accordance with the learning design of the teacher.
Results: Based on the results of my research, the utilization of video-based learning media using the VN editor application has a positive impact on the learning process at the elementary school level.
Conclusion. based on the discussion in this study, it can be concluded that the use of the VN application is very useful in the learning process of students at the elementary school level. Especially in this study on social science subjects.
Increasing English Vocabulary Skills Through The Singing Method At Elemantary Publich School Baruh 3 Sampang
Authors: Salim Halimah
Published: August 2024

Background. Learning English is something that must be done at the time this modern. The learning process also plays an important role in acquisition of the language. Schools need additional language lessons English because of the lack of teaching hours from local teachers.
Purpose. Children's needs in the school is something that must be completed because of learning English must be introduced from the elementary school level.
Method. Learning English through songs can be an effective means qualified in improving the memory and ability of students in learning English, this can be proven by the ease with which songs are followed and remembered by the students..
Results. Presence of the English teachers at schools will greatly assist the early learning process from a foreign language, especially if the teacher can teach English in various ways.
Conclusion. At the elementary level, such as elementary school, the emphasis on language learning should be emphasized English is at the most basic and most necessary language elements, namely: vocabulary, pronunciation, simple grammar, and simple conversation. Beside elements of the language, one thing that should always be remembered by English teachers is the importance of creating a comfortable and arousing situation and motivation to learn English.
Deep Neural Network on Detection of Road Distress Using Mixture of Predicted And Observed Data
Authors: Xiao Nathan , Cheng Wei
Published: August 2024

Roadway distress detection is essential for ensuring a safe and comfortable driving environment. However, given the irregular shape, small area size, and occasionally very large number, of the road distress objects, it is often laborious to label the distress instances during the training process under the fully supervised algorithm. To address this issue, the study strives to apply semi-supervised learning for distress detection that claims to reduce the cost associated with the labeling process, while maintaining or even improving the learning accuracy in some situations. The research features three distinct backbones of Mask R-CNN models, Unmanned Aerial System imagery of two resolutions, three levels of pseudo-labeled data, eleven threshold values and two types of assessment (that is, in-resolution and out-of-resolution). The results demonstrate that semi-supervised Mask R-CNN models are effective in detecting road distress. Nonetheless, the sensitive analysis is recommended in the future research to identify the optimal pseudo ratio that could generate the highest prediction accuracy.
Dampak Pelatihan Kepemimpinan Terhadap Perilaku dan Kinerja Inovasi Aparatur Pemerintah
Authors: Nihayati Badi Zulfa , Fardila Ucik Ana
Published: August 2024

Perilaku kerja inovasi perlu dimiliki setiap Aparatur Sipil Negara sebagai upaya pemenuhan kebutuhan pelayanan publik dengan optimal dan memiliki daya saing memadai di era dinamis. Program Inovasi Birokrasi pemerintah mendorong berbagai pelatihan agar para Aparatur Sipil Negara memiliki budaya inovasi hingga tercapai kinerja inovasi. Penelitian ini berupaya mencari hubungan antara pelatihan kepemimpinan pengawas dengan pembentukan budaya inovasi dan kinerja inovasi. Penelitian bersifat kuantitatif dengan variabel diturunkan dari dimensi Innovative Behavior Inventory/ IBI oleh Martin Lukes dan Ute Stephan; terdiri dari 4 aspek, kemudian diturunkan menjadi 7 variabel, dan selanjutnya disusun menjadi 24 indikator. Responden terdiri dari peserta Pelatihan Kepemimpinan Pengawas (PKP) di Badan Pengembangan Sumber Daya Manusia Provinsi Kalimantan Timur. Penelitian menunjukkan adanya hubungan positif antara pelatihan kepemimpinan terhadap pembagunan budaya inovasi dan kinerja inovasi, baik dari pihak individu maupun penerapan pada lembaga. Hasil penelitian kemudian dikaji secara teoritis sesuai teori dasar variabel penelitian, dan dikaji secara manajerial. Kedua kajian tersebut memiliki hasil bahwa pelatihan merupakan faktor penting bagi inovasi birokrasi di Indonesia dan perlu adanya dorongan dimensi kedua dari teori Martin Lukes dan Ute Stephan, yaitu Innovation Support Inventory/ ISI (dukungan stakeholder dan lembaga).
TERRITÓRIO, PLATAFORMAS DIGITAIS E LUTA DE CLASSES: dos conglomerados digitais às organizações contra-hegemônicas no ciberespaço PLATAFORMAS DIGITAIS E LUTA DE CLASSES:
Authors: Silveira dos Santos Jean , Rodrigues Mendonça Marcelo
Published: August 2024

As transformações espaciais impostas pelo paradigma tecnológico e pela reestruturação produtiva do capital têm atravessado as esferas do trabalho e da produção, impactando, decisivamente, o comportamento humano. Com efeito, o imperativo das Tecnologias de Informação e Comunicação elevou as contradições de classe a um novo nível, impondo formas recentes de geração do valor e, consequentemente, produzindo por dentro da contradição, organizações contra-hegemônicas. O objetivo deste artigo é compreender o ciberespaço enquanto uma nova dinâmica territorial que reforça a dominação econômica, política, cultural, ideológica tomando como exemplo alguns dos maiores conglomerados econômicos globais, ao mesmo tempo em que, possibilita mecanimos atualizados de organização da classe trabalhadora por meio das plataformas digitais.
O ENSINO DA GEOGRAFIA NOS ANOS INICIAIS: uma análise a partir do Referencial Curricular do município de Campo Grande/MS
Authors: Cruz Klémerson Soares Rodrigues da , Conte Cláudia Heloiza
Published: August 2024

O presente trabalho busca compreender como se efetiva o ensino de Geografia nos Anos Iniciais do Ensino Fundamental de Campo Grande/MS. Para isso, seu objetivo é analisar, por meio do Referencial Curricular do município, a abordagem dos conteúdos de Geografia. Os procedimentos adotados foram revisão bibliográfica e pesquisa documental, com ênfase no currículo da Rede Municipal de Ensino de Campo Grande - REME e na Base Nacional Curricular Nacional - BNCC. Verificou-se a importância da Geografia desde os primeiros anos do Ensino Fundamental, especialmente na perspectiva de leitura do mundo e formação da cidadania. A análise do Referencial Curricular, por sua vez, possibilitou entender que o ensino de Geografia no município se dá com base na BNCC e que, de forma geral, apresenta elementos importantes para a compreensão dos conteúdos geográficos. Apesar disso, algumas problemáticas ficaram evidentes, a exemplo da manutenção da Geografia Tradicional.
Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy
Authors: Nitta Yohei , Osaka Jiro , Maki Ryuto , Hakeda-Suzuki Satoko , Suzuki Emiko , Ueki Satoshi , Suzuki Takashi , Sugie Atsushi
Published: August 2024

Autosomal dominant optic atrophy (DOA) is a progressive form of blindness caused by degeneration of retinal ganglion cells and their axons, mainly caused by mutations in the OPA1 mitochondrial dynamin like GTPase (OPA1) gene. OPA1 encodes a dynamin-like GTPase present in the mitochondrial inner membrane. When associated with OPA1 mutations, DOA can present not only ocular symptoms but also multi-organ symptoms (DOA plus). DOA plus often results from point mutations in the GTPase domain, which are assumed to have dominant-negative effects. However, the presence of mutations in the GTPase domain does not always result in DOA plus. Therefore, an experimental system to distinguish between DOA and DOA plus is needed. In this study, we found that loss-of-function mutations of the dOPA1 gene in Drosophila can imitate the pathology of optic nerve degeneration observed in DOA. We successfully rescued this degeneration by expressing the human OPA1 (hOPA1) gene, indicating that hOPA1 is functionally interchangeable with dOPA1 in the fly system. However, mutations previously identified did not ameliorate the dOPA1 deficiency phenotype. By expressing both WT and DOA plus mutant hOPA1 forms in the optic nerve of dOPA1 mutants, we observed that DOA plus mutations suppressed the rescue, facilitating the distinction between loss-of-function and dominant-negative mutations in hOPA1. This fly model aids in distinguishing DOA from DOA plus and guides initial hOPA1 mutation treatment strategies.
The role of heterochronic gene expression and regulatory architecture in early developmental divergence
Authors: Harry Nathan D , Zakas Christina
Published: August 2024

New developmental programs can evolve through adaptive changes to gene expression. The annelid Streblospio benedicti has a developmental dimorphism, which provides a unique intraspecific framework for understanding the earliest genetic changes that take place during developmental divergence. Using comparative RNAseq through ontogeny, we find that only a small proportion of genes are differentially expressed at any time, despite major differences in larval development and life history. These genes shift expression profiles across morphs by either turning off any expression in one morph or changing the timing or amount of gene expression. We directly connect the contributions of these mechanisms to differences in developmental processes. We examine F1 offspring – using reciprocal crosses – to determine maternal mRNA inheritance and the regulatory architecture of gene expression. These results highlight the importance of both novel gene expression and heterochronic shifts in developmental evolution, as well as the trans-acting regulatory factors in initiating divergence.
Pre-touch reaction is preferred over post-touch reaction in interaction with displayed agent
Authors: Shiomi Masahiro
Published: August 2024

A pre-touch reaction, which is a response before a physical contact, is an essential factor for natural human-agent interaction. Although numerous studies have investigated the effectiveness of pre-touch reaction design for virtual agents in virtual reality (VR) environments and robots in physical environments, one area remains underexplored: displayed agents, i.e., on-screen computer graphics agents. To design an appropriate pre-touch reaction for such a displayed agent, this article focused on the display’s physical boundary as a criterion for the pre-touch reaction of the agent. This article developed a displayed agent system that can detect both the touch events on the screen and the pre-touch behaviors of the interacting people around the display. This study examined the effectiveness of the pre-touch reactions of the displayed agent by the developed system in experiments with human participants. The findings revealed that people significantly preferred pre-touch reactions over post-touch reactions in the context of perceived feelings.