bluuebunny/crossref_metadata_2025 huggingface dataset:
Key genes associated with prognosis and metastasis of clear cell renal cell carcinoma
Authors: Zhong Tingting , Jiang Zeying , Wang Xiangdong , Wang Honglei , Song Meiyi , Chen Wenfang , Yang Shicong
Published: January 2022

Background

Clear cell renal cell carcinoma (ccRCC) is a tumor that frequently shows the hematogenous pathway and tends to be resistant to radiotherapy and chemotherapy. However, the exact mechanism of ccRCC metastasis remains unknown.

Methods

Differentially expressed genes (DEGs) of three gene expression profiles (GSE85258,GSE105288andGSE22541) downloaded from the Gene Expression Omnibus (GEO) database were analyzed by GEO2R analysis, and co-expressed DEGs among the datasets were identified using a Venn drawing tool. The co-expressed DEGs were investigated using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, and hub genes were determined based on the protein-protein interaction network established by STRING. After survival analysis performed on UALCAN website, possible key genes were selected and verified in ccRCC cell lines and ccRCC tissues (n = 44). Statistical analysis was conducted using GraphPad Prism (Version 8.1.1).

Results

A total of 104 co-expressed DEGs were identified in the three datasets. Pathway analysis revealed that these genes were enriched in the extracellular matrix (ECM)–receptor interaction, protein digestion and absorption and focal adhesion. Survival analysis on 17 hub genes revealed that four key genes with a significant impact on survival: procollagen C-endopeptidase enhancer (PCOLCE), prolyl 4-hydroxylase subunit beta (P4HB), collagen type VI alpha 2 (COL6A2) and collagen type VI alpha 3 (COL6A3). Patients with higher expression of these key genes had worse survival than those with lower expression.In vitroexperiments revealed that the mRNA expression levels ofPCOLCE,P4HBandCOL6A2were three times higher and that ofCOL6A3mRNA was 16 times higher in the metastatic ccRCC cell line Caki-1 than the corresponding primary cell line Caki-2. Immunohistochemistry revealed higher expression of the proteins encoded by these four genes in metastatic ccRCC compared with tumors from the corresponding primary sites, with statistical significance.

Conclusion

PCOLCE, P4HB, COL6A2 and COL6A3 are upregulated in metastatic ccRCC and might be related to poor prognosis and distant metastases.
Predicting continuous ground reaction forces from accelerometers during uphill and downhill running: a recurrent neural network solution
Authors: Alcantara Ryan S. , Edwards W. Brent , Millet Guillaume Y. , Grabowski Alena M.
Published: January 2022

Background

Ground reaction forces (GRFs) are important for understanding human movement, but their measurement is generally limited to a laboratory environment. Previous studies have used neural networks to predict GRF waveforms during running from wearable device data, but these predictions are limited to the stance phase of level-ground running. A method of predicting the normal (perpendicular to running surface) GRF waveform using wearable devices across a range of running speeds and slopes could allow researchers and clinicians to predict kinetic and kinematic variables outside the laboratory environment.

Purpose

We sought to develop a recurrent neural network capable of predicting continuous normal (perpendicular to surface) GRFs across a range of running speeds and slopes from accelerometer data.

Methods

Nineteen subjects ran on a force-measuring treadmill at five slopes (0°, ±5°, ±10°) and three speeds (2.5, 3.33, 4.17 m/s) per slope with sacral- and shoe-mounted accelerometers. We then trained a recurrent neural network to predict normal GRF waveforms frame-by-frame. The predicted versus measured GRF waveforms had an average ± SD RMSE of 0.16 ± 0.04 BW and relative RMSE of 6.4 ± 1.5% across all conditions and subjects.

Results

The recurrent neural network predicted continuous normal GRF waveforms across a range of running speeds and slopes with greater accuracy than neural networks implemented in previous studies. This approach may facilitate predictions of biomechanical variables outside the laboratory in near real-time and improves the accuracy of quantifying and monitoring external forces experienced by the body when running.
Ahmed Mustafa al-Maragi as a Commentator and His Work Titled “Tefsîru’l-Merâğî”
Authors: DOĞRU Mehmet Seri
Published: January 2022

Kur’an’ın mana ve maksatlarını anlama çabası, Kur’an’la olan irtibatın en önemli göstergelerindendir. Ayetlerini doğru bir şekilde açıklamak, Kur’an’ı doğru anlamaya dayanır. Çünkü Kur’an, her Müslümanın en temel hidayet rehberidir.
Onun ayetlerini anlamaya dönük her türlü çaba, bu ilâhî kitabın bizlere sunmak istediği bilgiyi elde etme yolunda atılmış önemli bir adımdır. Nüzul sürecinde ilk olarak Hz Peygamber (s.a.v.) döneminde, müşkil lafızların açıklanmasını
amaç edinen bu çabalar, tefsir ameliyesini oluşturan önemli adımlar olarak çağdaş döneme kadar muhtelif ekol ve anlayışlar şeklinde varlığını günümüze kadar sürdürmüştür.İslâm tefsir geleneği, toplumsal birçok anlayış ve yaklaşımı
bünyesinde barındırmıştır. Özellikle son yüzyılda Kur’ân mesajının, Müslümanların yaşadığı soysal ve ekonomik problemlere çözüm olacak şekilde yeniden yorumlanmasını öngören İctimâî Tefsir anlayışı bunlardan sadece biridir. Bu
ekol, fikri alt yapısı bakımından Cemâleddin Efgânî’nin oluşturduğu İslâmî yenileşme hareketiyle revaç bulmuş ve günümüze kadar etkinliğini sürdürmüş bir tefsir ekolüdür. Hatta son asırda telif edilen birçok tefsir eserlerinin
ictimâî yaklaşımla kaleme alınması, bu ekolün 20. Yüzyıl tefsir akımı şeklinde isimlendirilmesine de yol açmıştır. Bu makalenin konusu, İctimâî tefsir ekolünün 20. asırdaki önemli temsilcilerinden biri olan Ahmed Mustafa el-Merâğî’nin
hayatı, ilmî kişiliği, eserleri ve “Tefsîru’l-Merâğî” isimli tefsiridir. Makalede Merâğî’nin hayatı genel hatlarıyla ele alınarak ilmî kişiliği anlatılmıştır. Ayrıca müellifin, İctimâî tefsir yaklaşımıyla kaleme alınmış kapsamlı
çalışması olan “Tefsîru’l-Merâğî” isimli eserinin genel özellikleri hakkında bilgi verilmiştir. Eserin, tefsir alanındaki yeri ve konumuna ilişkin değerlendirme yapılmış; özellikle ictimâî tefsirin temel ilkeleri açısından eserin
önemine vurgu yapılmıştır.
Atypical Presentation of Spindle Cell Carcinoma
Authors: Singh Harshika , Khanduri Sachin , Krishnam Anvit , Yadav Poonam , Chawla Harleen
Published: January 2022

Spindle Cell Carcinoma (SCC) of the lung is a rare entity. Computed Tomography (CT) and histopathology forms the basis of diagnosis. Here, authors presented a case of a 30-year-old male patient who reported with complaints of painless abdominal swelling associated with shortness of breath and fever. The patient underwent Contrast Enhanced CT (CECT) of chest, abdomen and pelvis with percutaneous CT guided biopsy. The final diagnosis was SCC of lung with transdiaphragmatic spread to abdomen. This case is clinically significant as it depicts unusual spread of SCC presenting as thoracoabdominal mass.
The Impact of Customer Behavior on E-business during of the COVID-19 Crisis in Jordan
Authors: Muhammad Harith Adnan , Mohammed Ali Ibrahim , Almomani Amer Abdelwali
Published: January 2022

Aims: This study was conducted to study the impact of customer behavior on e-business in Jordan in light of the increasing spread of the virus.

Study Design: A quantitative research.

Place and Duration of Study: Jordan, between January - September 2020.

Methodology: The Statistical Analysis Software (SPSS) software is used by the researcher. The survey questionnaires framed by the researcher are helping the researcher in representing the data appropriately

Results: The results showed that online purchase was acceptable and high during the Corona pandemic period despite the complete paralysis of movement Before the customer so that there is an alternative in emergency and necessary cases such as the Corona pandemic and the need to take into account the terms and behavior of the consumer when advertising, selling or promoting the commodity on electronic sales platforms.

Conclusion: Through the foregoing according to the data analysis carried out above shows the negative impact on e-business in Jordan due to the Coronavirus (COVID-19) the negative impact created affects sales as well as the purchasing behavior of customers. The business environment in Jordan is seen as weak due to COVID-19. The challenges that retailers in the e-commerce business face is declining customer buying behavior. Also, lower buying behavior reduces bids and shipping as per the surveys carried out this will lead to the deterioration of the e-business as well as huge losses that the e-business will incur. Research questions as well as research objectives set by the researcher a greater impact has been made on the current e-business in the Jordanian market. Buy food products from food stock for this reason. And the hypothesis of the research papers he developed lies a change in food contamination. For this reason, human-to-human contact is restricted which leads to the deterioration of e-commerce sales. Thus the presented analysis supports for this reason a greater impact has been created on the existing e-business in the Jordanian market since there is a concern of the buyer that with Delivery of food products through the electronic company.
Relationship among Continuous Probability Distributions and Interpolation
Authors: Enwere Kelachi P. , Ogoke Uchenna P.
Published: January 2022

Aims: The Study seeks to determine the relationship that exists among Continuous Probability Distributions and the use of Interpolation Techniques to estimate unavailable but desired value of a given probability distribution.

Study Design: Statistical Probability tables for Normal, Student t, Chi-squared, F and Gamma distributions were used to compare interpolated values with statistical tabulated values. Charts and Tables were used to represent the relationships among the five probability distributions.

Methodology: Linear Interpolation Technique was employed to interpolate unavailable but desired values so as to obtain approximate values from the statistical tables. The data were analyzed for interpolation of unavailable but desired values at 95% a-level from the five continuous probability distribution.

Results: Interpolated values are as close as possible to the exact values and the difference between the exact value and the interpolated value is not pronounced. The table and chart established showed that relationships do exist among the Normal, Student-t, Chi-squared, F and Gamma distributions.

Conclusion: Interpolation techniques can be applied to obtain unavailable but desired information in a data set. Thus, uncertainty found in a data set can be discovered, then analyzed and interpreted to produce desired results. However, understanding of how these probability distributions are related to each other can inform how best these distributions can be used interchangeably by Statisticians and other Researchers who apply statistical methods employed in practical applications.
Efficacy of Herbal Medicine Administration using Neem (Azadirchta indica L) Leaves as Case Study
Authors: Oladejo Duduyemi , Regina Patinvoh , Aisha Adelowo , Akinbomi J. G.
Published: January 2022

Plants used for treatment of diverse ailments primitively are concocted and used indiscriminately. The efficacy of "Herbal medicine" which is an ancient tradition, used in some parts of Nigeria was investigated to establish herbal applications of Neem (Azadirachta indica) leaves.  Neem leaves (Azadirachta indica) was popularly recognised for the treatment of malaria fever. The leaves were plucked at appropriate peak period of the day when oil and moisture contents were recorded maximum. The peak period of contents was found to occurred between 8am-10am on a very sunny days, 10am to 12 on cool days, and 3:00pm to 5:00pm on cloudy days. Aqueous extract from macerated Neem leaves was subjected to qualitative and quantitative analysis. Available phytochemicals evaluated include; saponin (34.89mg/g), tannin (31.715mg/g), flavonoid (31.835mg/g), phenol (43.59mg/g), terpernoid (14.585mg/g), cardiac glycosides (39.335mg/g), steroid (16.185mg/g) and alkaloid (28.76mg/g). These values differ significantly to recommended oral dosage formulation for human consumption: Saponin (1.433ml), Tannin (1.418ml), Flavonoid (13.91ml), Phenol (2.29ml), Terpernoid (8.23ml), Cardiac Glycosides (0.003177ml), Steroid (0.62mg/g). Consequently, local consumption of herbal resources should be regulated to avoid abuse and long or short-term effects of drug contents as proven in the neem leaves as local herbs.
Evaluation on the Effect of Silica (DE) for Growth and Quality of Mango Kesar
Authors: Vidya A. , Hanumantharayya B. G. , Kumari R. Vasantha
Published: January 2022

An experiment was conducted during 2012-2014 at Kittur Rani Channamma College of Horticulture, Arabhavi, Gokak (Karnataka), India to study the effect of silicon on  yield and quality of mango cv. Kesar. The experiment was laid out in a randomized complete block design with nine treatments replicated five times. The results revealed that, the highest yield per tree (140.93 kg/tree) was recorded in the treatment supplemented in (T5) Half of RDF + DE 600 kg/ha which significantly more than the compared to control during 2012-2013, 2013-2014 and pooled data. It was noticed that the (T7) RDF + DE 300 kg per hectareas RDF + DE 300 kg/ha was best on the basis of physical characteristics like increased in length, diameter and volume of the fruit, and the treatment was significantly higher than the untreated control mango fruits. The treatment also helped in better chemical characteristics like increased TSS, total sugars, and reducing sugars and optimum physiological loss in weight, resulting in improved keeping quality at ambient conditions (25-350C, 50-60% RH). The T7 treatment was judged as the most effective soil application for the mango cv. Kesar that helped in increasing the quality of the mango fruits during storage even after 18 days of storage. The same treatment was also found to be more effective and significantly more than the compared to control during 2012-2013, 2013-2014 and pooled data with respect to organoleptic parameters for the mango cv. Kesar.
Exploration of Genetic Parameters of Pea Genotypes Using Different Environmental Conditions
Authors: Jaiswal R. P. , Pandey B. R. , Kumar V. , Pandey S. K.
Published: January 2022

The estimate of genetic variability was observed for fifteen traits on fifty two genotypes. The ANOVA indicated that the mean sum of squares due to genotypes were highly significant for all the traits, respectively in all the environmental conditions. High magnitude of phenotypic coefficient of variation was observed than the genotypic coefficient of variation for all the characters under study. High genotypic and phenotypic coefficient of variations were exhibited for number of secondary branches/plant, Pod bearing length, number of primary branches/plant, number of pods/plants, number of seeds/plant, seed yield/plant (gm), biological yield/plant (gm), First flowering node and harvest index (%) in all six and pooled over environments. The above finding revealed the presence of substantial amount of genetic variability for the traits, which exhibited high magnitudes as well as less influence of environment on the expression of concerned traits. Day to first flowering node, number of seed/pods , hundred seed weight (gm), harvest index and days to flower initiation exhibited moderate genotypic and phenotypic coefficient variation in all the environments. Low genotypic and phenotypic coefficient of variation was observed for pod bearing length in all the environments, this reveled high influence of environment.
Optimization of Boron and Zinc on the Growth and Yield Parameters of Tomato (Solanum lycopersicum L.) in Nalanda District
Authors: Umesh U. N. , Rani Kumari Vibha , Sinha Jyoti
Published: January 2022

The field experiment was carried out to overcome the poor growth and yield of tomato due to imbalance use of fertilizer and micronutrient deficiency. The objective to conduct this experiment was soil application of micronutrients alongwith nitrogen, phosphorus and potash for growth and yield enhancement. The maximum 90.39 cm plant height,the heighest 14.38 number of branches,the maximum 29.50 number of fruits per plant, heighest fruir weight per plant 2.46 kg per plant with yield of 518.25 quintal per heactare in case of technology option three application of 120.80.80 kg N:P:K ha-1 alongwith 10kg zinc and 1 kg boron per hectare as basal dose in comparision to other treatments. The lowest 80.45 cm plant height, least number of branches per plant 8.13,lesser number of fruit per plant 24.13, least fruit weight 2.18 kgper plant with minimum yield of 450.50 quintal per hectare was recorded in control.
Awareness about Human Brucellosis in Healthcare Professional in India
Authors: Patel Jinal , Singh Suman
Published: January 2022

Introduction: Human brucellosis is a widespread zoonosis of serious public health consequences. The infection is transmitted from animal to human through direct contact with infected animals or consumption of infected, unpasteurized animal milk. Being a disease with wide and non-specific clinical manifestations, a case of brucellosis can be detected only if the treating health care professional is aware of the disease and keeps a high rate of suspicion when dealing with suspected cases. We surveyed to find the extent of awareness about Human brucellosis in healthcare professionals in Gujarat, India.

Methodology: A cross-sectional study was conducted among healthcare professionals from December 2020 to May 2021 using a self-administrated questionnaire. This study included healthcare professionals including AYUSH practicing in Gujarat. A validated questionnaire consisting of 23 items was administered to assess the knowledge of professionals toward suspecting, diagnosing, preventing, and managing a case of brucellosis. Both physical and Google forms were used to collect data. Data were analyzed using Statistical Package for the Social Sciences (SPSS) program, IBM version 22.

Results: Sixty-nine healthcare professionals responded to the questionnaire. The findings of the study showed overall good awareness about brucellosis with a higher rate of knowledge in allopathic healthcare professionals and nurses in comparison to AYUSH doctors. Nearly 50% of respondents did not know the treatment as well as the preventive potential of human brucellosis.

Conclusion: The current study suggests a need for creating more awareness in the healthcare professional, particularly AYUSH practitioners about brucellosis for better management and prevention.
GIS and Remote Sensing Analysis of the Impact of Land use Land Cover Change on Forest Degradation: Evidence from the Central Part of Taraba State, Nigeria
Authors: Abba Umar Jauro , Taiye Adewuyi , Bakoji Yusuf Mohammed , Mohammed Bashir Babanyaya , Umar Adamu Auwal , Abdullahi Ibrahim , Isa Mohammed Saleem , Isah Abubakar , Ishaku Ayesukwe Rimamsikwe
Published: January 2022

Forest is a fundamental, significant, and valuable component of a sustainable environment. Ecosystem services, biodiversity development, and economic growth in any nation depend on the proficient use of forests and their resources. However, deforestation has remained the single most important environmental phenomenon threatening the existence of the forest environment in Nigeria. This study was carried out to assess the exploitation of forestland in the central zone of Taraba state using GIS and remote sensing techniques. The satellite imageries used are Lands at imageries of 2006, 2012, and 2018. Ground Control points (GCPs) were obtained from Google earth to validate the coordinates of the classified imageries. The result obtained from 2006 classification showed that thick forest occupied the total of 1685448.99 ha equivalent to 80.38% and was the highest land cover suffering a decline in the area amounting to 694696 ha which equals to 33.13% in 2018. The pattern of land cover changes at the early stage was restricted to dissection and perforation in 2006. A remarkable expansion of bare land patches accompanied by total attrition of thick forest was identified due North in Bali local government area as compared to Gashaka and Kurmi local governments that have fragmented and little shrinking pattern of changes from 6.87% in 2006 to 37.65% in 2018. This shows that; as bare land increases, thick forests keep on decreasing within thirteen (13) years. It was recommended that increased reforestation efforts, sensitization and periodical campaigns against deforestation, and redesign of the existing forestry laws by the state government to curtail incessant incidents of deforestation in the study area be undertaken.
Evaluation of Anti-depressant, Anti-anxiety and Muscle Relaxant Activity of Hydroalcoholic Extract of Aerva javanica Roots
Authors: Waqas Mohammed , Sharma Peeyush Kumar , Kumar Yadav Sandeep , Asif Mohammad
Published: January 2022

Aims: To evaluate anti-depressant, anti-anxiety and muscle relaxant activity of hydroalcoholic extract of Aerva javanica roots in various experimental animal models.

Study Design: Animal study.

Place and Duration of Study: The study was conducted in Bilwal Medchem and Research Laboratory, Jaipur from July 2021-August 2021.

Methodology: The root powder of Aerva javanica was extracted with hydroalcoholic solvent (70% ethanol). The hydroalcoholic extract at three doses 100 mg/kg, 200 mg/kg, and 400 mg/kg was checked for anti-depressant and skeletal muscle relaxant activity in the experimental animal models. To determine the anti-depressant activity tail suspension test, locomotor activity, open field test, and MAO inhibitor assay were done; to determine the anti-anxiety activity hole board test was used; and to determine the skeletal muscle relaxant activity rotarod test, grip strength test, and chimney test were done.

Results: In the tail suspension test, the extract at 200 mg/kg and 400 mg/kg significantly reduced the duration of immobility compared to normal control (p<0.0001). The extract at dose 400 mg/kg significantly reduced MAO-A and MAO-B activity compared to the normal control group (p<0.01 and p<0.05, respectively). The extract at 200 mg/kg and 400 mg/kg were able to decrease locomotor activity in actophotomoter and increased time spent in centre square in open field test revealing the sedative effect of the extract. In hole board test, the extract at dose 400 mg/kg and 200 mg/kg significantly increased number of head dip count (p<0.0001 and p<0.001) respectively. In the rotarod test, the extract at dose 200 and 400 mg/kg decreased the time spent on the rotating rod (p<0.0001), compared to normal control. Similarly, in the grip strength test the extract at dose 200 and 400 mg/kg decreased the time spend on suspended wire revealing the skeletal muscle relaxant property of the test extract.

Conclusion: Based on the result, it can be concluded that the extract exert anti-depressant, anti-anxiety and skeletal muscle relaxant like activity in the experimental rat which was hypothesized to be attributed to the flavonoids present in the hydroalcoholic root extract of Aerva javanica.
Protocol on Effect of Planned Teaching on Knowledge Regarding Menstrual Blood Banking among Nursing Students
Authors: Ngente Elizabeth Remsangzuali , Chaudhari Vaibhav , Fodekar Nita , Gathe Pranali , Ghume Samiksha , Jambhulkar Shruti , Gomase Kavita
Published: January 2022

Background: The student’s changing habits varies depending on their intellectual level. Transition concerns are also present among college students. You have issues with your parents and siblings due to shyness and aggression. They are having academic adjustment issues as a result of the new academic pattern, atmosphere, and faculties. Academic transition includes finding inspiration, taking actions to satisfy academic obligations, and dealing with academic frustration.

Aim: To evaluate the effectiveness of planned teaching on knowledge regarding Menstrual Blood Banking among nursing students.

Methods: The data gathering process began from 5th April 2021. The investigators visited selected nursing school in Sawangi (M) Wardha City and got the mandatory authorization from the concerned authorities. To ensure better coordination during data collection, the researchers introduced themselves and told them about the purpose of the study. The researchers contacted the final year nursing students of selected area and clarified the purposes of the study and described how it will be helpful for them. They investigated their will to take part in the study and attain permission from them. They will assess their knowledge regarding Menstrual Blood Banking among Nursing Students by using structured questionnaire and after that, they will give them planned teaching regarding Menstrual Blood Banking. Then, after the seventh day of planned teaching, they will assess their post-test knowledge score regarding Menstrual Blood Banking. The investigators acknowledged all the study samples as well as the authorities for their support. The conclusion will be drawn from the results and will be published in peer reviewed journal.

Materials and Methods: The information was gathered from nursing students at nursing colleges in Wardha district. The research method was quantitative, and the study design was pre-experimental, one group pre-test post-test. The research was conducted at Wardha district's selected nursing colleges. Students make up the population, and samples were taken from 64 nursing students. The data was collected using a self-administered questionnaire and a targeted sample strategy. The tools for data collection used was -socio demographic data (age, education, religion, course, year of study and residence of the students),self-administered questionnaire on Menstrual Blood Banking and lesson plan on Menstrual Blood Banking.

Expected Results: This study is planned to assess knowledge regarding Menstrual Blood Banking among nursing students. Hence, it is expected to identify the effectiveness of planned teaching regarding Menstrual Blood Banking. The conclusion will be drawn from the results and will be published in per review journal.
Mucormycosis in Post COVID-19 Patients: A Case Study
Authors: Shembekar Amitendra , Nagrale Ninad , Bankar Nandkishor
Published: January 2022

Introduction: Acute respiratory distress syndrome (ARDS) is a common complication of severe pneumonia virus, such as the flu and COVID-19, which requires critical treatment, including asthma support, corticosteroids, and other treatments to prevent acute respiratory tract inflammation. Although steroid treatment is limited to the treatment of viral pneumonia, it is usually a double-edged sword, leading to increased morbidity and mortality. Mucormycosis is a fungal emergency with a high tendency for contaguous spread and a poor prognosis if not detected and treated promptly. Mucormycosis is believed to be caused by uncontrolled diabetes mellitus (DM) and other immunosuppressive disorders, such as corticosteroid therapy.

Aim: To discuss causality factor of mucormycosis in COVID-19 infection.

Conclusion: COVID-19 is correlated with a high rate of secondary infections, both bacterial and fungal, most likely as a result of immune dysregulation. Furthermore, the widespread use of steroids and broad-spectrum antibiotics as part of the COVID-19 remedy can result in the production or exacerbation of pre-existing fungal diseases. Physicians should be mindful of the likelihood of invasive secondary fungal infections in patients with COVID-19 infection, especially in those that have pre-existing risk factors, and should be able to detect and treat these infections early in order to reducing mortality and morbidity.
Estimation of Blood Pressure, Pulse Rate, Waist Circumference, BMI and BMR among PCOS Individuals
Authors: Rasveya S. , Devi R. Gayatri , Priya A. Jothi
Published: January 2022

Introduction: Polycystic ovarian syndrome (PCOS) is an endocrine disorder which will affect the female’s reproductive health, there are many risk factors found in the PCOS individuals such as irregular menstrual cycle, infertility, obesity, excess hair growth, hyperandrogenemia. The aim of the study is to estimate the blood pressure and pulse rate among PCOS individuals and to compare it with the normal subjects.

Materials and Methods: A group of 20 PCOS individuals and 20 normal individuals have been chosen from Saveetha dental college with age of 18-25 years whose blood pressure, pulse rate, waist circumference, BMI, BMR are measured, the blood pressure and pulse rate were measured with a automatic blood pressure monitoring machine and the waist circumference was measured with a inch tape from last rib and the iliac crest at its small parameter. The simple random sampling method is used to minimize the sampling bias. Data was collected and analyzed by an independent sample‘t’ test.

Results: When comparing with control healthy individuals, the systolic blood pressure (SBP) of PCOS individuals seem to be higher than the control subjects. The diastolic blood pressure (DBP) is also slightly higher for PCOS individuals. The pulse rate of normal individuals is higher than the PCOS individuals. The diastolic blood pressure had a significant value of about 0.002 which is less than 0.05 so it is significant

Conclusion: From this study it is evident that when PCOS is seen in women it not only affects the gynecological sphere it also affects the cardiovascular activity which may even have fatal outcomes. So it is mandatory for the PCOS subjects to have a proper diet, proper sleep, physical activity, and very importantly to have a stress free life.
Outcome of COVID-19: Diabetes and Obesity
Authors: Gunta Rithika
Published: January 2022

Today the world is facing one of the biggest crisis, due to a new beta-corona virus emerged from Wuhan in China, on December 2019. WHO declared ‘acute respiratory syndrome COVID-19 (SARS Co-2)’as a pandemic on March 12, 2020. Corona viruses are enveloped positive single stranded RNA viruses, causing severe acute respiratory syndrome in the infected individuals. The risk of getting infected by covid-19 is similar in all the individuals across the nation. But the outcome of the infection varies from one individual to another, depending on the comorbidities present in them. The most vulnerable group of patients in respect to severity of outcome of the infection are the once with unbalanced heath conditions like age (>65 years), immune-compromised, hypertension, type 2 diabetes, increased insulin resistance, cardiovascular diseases, chronic kidney disease, chronic liver disease, vasculitis(vascular inflammation)and obesity. It is now a public knowledge that diabetes and obesity are a risk factor for any individual as these conditions can exacerbate the manifestations of COVID-19 infections thus increasing the severity of the condition, that may require hospitalization of the patient, later may even require intensive care unit or/and mechanical ventilation, with increased risk of mortality rates. In diabetic patients it is mainly due to failure in controlling the glucose levels and the risk of ketoacidosis. In patients with obesity lipid peroxidase creates reactive lipid aldehydes leading to poor prognosis.
Knowledge, Attitude and Practice of Ischemic Heart Disease Patients towards Their Medication
Authors: Akshay T. V. , Shruthilaya C. K. , Rafiyath V. V. , Rajesh K. S. , Subrahmanyam K. , Kumar Raman Rajesh
Published: January 2022

Objective: Ischemic heart disease is mostly seen among all Cardiovascular diseases and is responsible for more than 80% of cardiovascular disease deaths. This study has been developed to design and to validate a Knowledge, attitude and practice (KAP) Questionnaire in order to assess the knowledge, attitude and practice of ischemic heart disease patients towards their medications.

Study Design: Prospective observational study

Methods: The study was conducted for duration of six months among 336 patients. The study subjects taken were above 18 years of age, who was diagnosed with Coronary Artery Disease by a Consultant Cardiologist in Cardiology Department. Practice questionnaires and all the details were explained by the investigator before filling the KAP forms. The data was tabulated and statistically analysed by SPSS software.

Results: 336 patients including both males and females were enrolled in the study. Majority of the patient were having good knowledge about the disease conditions that is 50% of the patients were aware about the ischemic heart disease. 326 (97%) of the 336 research participants were aware of the signs and symptoms of ischemic heart disease. Majority of the patient have an attitude towards the adverse conditions related to the disease i.e. 91.4% were aware of consulting a physician when they came across a side effect. 85.45% of the study subjects think that non-compliance to medication can lead to worsening of their condition. 98.2% of the study subjects are willing to take the treatment recommended by their doctor. Considering the practice, 81.5% the study subjects were ready to follow all the instructions given by the doctor.

Conclusion: Findings from this study provide a better understanding of “knowledge, attitude and practice” in Ischemic heart disease patients towards their medications. Estimating the knowledge, attitude and practices of the community has sufficiently provided crucial baseline information for the implementation of primary and secondary preventive programs.
Evaluation of Nootropic Activity of Leaf Extract of Anacardium occidentale L.
Authors: Salian Meghna , Khandige Prasanna Shama
Published: January 2022

One of the plants that have been used for enthno medicinal purposes in traditional civilization is Anacardium occidentale L. of the family Anacardiaceae is native to Brazil also found in tropical countries such as Malaysia and India commonly known as cashew. The purpose of this study is to determine the in-vitro and in-vivo cognitive effects of an ethanolic leaf extract of the herb Anacardium occidentale on albino rats. Orally the ethanolic extract was administered in two doses (100 mg/kg and 400 mg/kg). The Elevated Plus maze and Y-maze showed statistically significant improvement in the memory process. The estimation of acetylcholinesterase enzyme in rats brain also shows improvement in the memory process by reducing acetylcholinesterase activity. Disorders related to cognition are one of the major health problems and increasing day by day especially affecting the elder individual. There is no proper medication for the impairment of memory. The study reveals that the ethanolic extract of the leaf of Anacardium occidentale has dose-dependent memory-enhancing performance. Synthetic drugs have a lot of side effects, whereas drugs belongs to natural substances have least side effect compared to synthetic one, which has gained a lots of importance. These studies need to be documented effectively. Research findings were contributed to meet the future needs in general healthcare, research, and conservation of endangered species and may give a lead to the discovery of newer drugs.
Telehealth for COVID-19 Pandemic
Authors: Agrawal Pratik
Published: January 2022

The COVID-19 epidemic has caused huge strain on health infrastructure. In this pandemic, burden on healthcare workforce is rising, as there was need to give treatment, observing, and subsequent follow-ups during the epidemic. Consequently, the Covid-19 pandemic has profoundly affected healthcare. Clinical focuses are presently reacting to CORONA VIRUS 19 through fast appropriation of advanced devices and advances, for example, Tele health and effective consideration which allude to the conveyance of medical care directing computerized or a ways off utilizing Information and Communications Technology (ICT) for therapy of One still living. Tele health was required to convey opportune consideration while limiting openness to secure clinical professionals and One still living. In like manner, a quick writing audit was led, and 35 examination contemplates distributed from 2019 to May 2020 were utilized to give hypothetical and functional proof on the hugeness of utilizing Tele health and effective consideration for far off treatment of One still living during the CORONA VIRUS 19epidemic. This article gives down to earth manage dependent on the best way to utilize Tele health and effective consideration during the CORONA VIRUS 19 epidemic. This investigation gives suggestion on the possibilities of combining effective consideration arrangements soon towards adding to incorporate advanced innovations into medical services.

Materials and Methods: The material required for the review was taken from the databases of PubMed, Web of science,the from the website of World Health Organization and the patients data of SMHRC and DMMC Wanadongari Nagpur.
Telemedicine during COVID-19 Pandemic in Saudi Arabia: Oral and Maxillofacial Surgeons’ Knowledge and Implementation
Authors: Eltahir Manal Abdalla , Alshommemri Amjad Ebrahim , Alyahya Rayan Suliman
Published: January 2022

Telemedicine can significantly improve health care delivery for patients with limited access to medical services. Innovative uses of this kind of technology in the provision of healthcare is increasing with the emergence of the virus causing the disease COVID-19, there is an urgency to expand the use of technology to help people who need routine care. This study aimed to assess oral and maxillofacial surgeons' knowledge of telemedicine and its applications, and incorporation of telemedicine into their clinical practice during the COVID-19 pandemic.

Methodology: This is a cross section, Questionnaire based study conducted among oral and maxillofacial surgeons in Saudi Arabia from November 2020 to January 2021. The study sample included 200 oral and maxillofacial surgeons from different regions in Saudi Arabia which has been calculated depend on reality of the Saudi health workforce during the next ten years 2018-2027 book and the total number of OMS and oral surgeons who was registered was approximately 300. The self-administered questionnaire (which was constructed after extensive reviewing of the literature in the same context) was distributed among the selected surgeons using online platform; the components of that questionnaire were: socio demographic characteristics, knowledge of telemedicine technology, using of telemedicine before and during COVID-19 and security of telemedicine technology. A Scoring Criteria used to indicate the knowledge of OMS and oral surgeons towards the use of telemedicine technology. All statistical analyses were performed using SPSS version 21.

Results: A total of 69 OM surgeons were responded, of which 52.2% were females. The knowledge of the surgeons regarding telemedicine was moderate among 43.5% (mean: 11.6; SD: 4.12, out of 20 points). Surgeons who were working in the private clinic (F=2.982; p=0.027), those who had heard of telemedicine (t=4.987; p<0.001) and those who implemented telemedicine at a current workplace before COVID-19 (t=3.873; p<0.001) had significantly better knowledge score than the rest.

Conclusion: Although there was an increased implementation of telemedicine use during the covid-19 pandemic, the oral and maxillofacial surgeon’s knowledge about it seems to be low.
Study on Work Safety for Employees in Radiology Department
Authors: Dabhekar Praful R. , Naik Rupali
Published: January 2022

Background: Working staff in the radiology department are exposed to harmful factors such as Radiation exposure, injuries; needle pricks while performing an investigation, leads to exposure to body fluids, muscle stress due to wearing heavy lead aprons, and while moving portable equipment for examinations. Strategies to prevent and reduce such harmful factors are guaranteed by taking regular inspections by radiation safety officers.  Safety supervision in radiology is important in shielding the patients, radiologists and healthcare staff. Observational safety audits and regular inspections in the radiology department for staff safety are the main and important parts of this study.

Objective: To assess and evaluate the current safety measures in Radiology Department and Scope of innovations and interventions in current working safety condition awareness. 

Methods: All employees working in radiology department satisfying the inclusion criteria are evaluated for the study. A survey carried out related to general working and routine procedures carried out in radiology department. Regular audits and inspection studies are covered in the study. The study consists of closed-ended questions regarding the profession and the knowledge of the basic safety measures in diagnostic and special scans in radiology department.                                   

Results: Employees in the radiology department are highly aware about work safety measures. There are regular safety audits and inspection studies are carried out by RSO and concerning departments. There is also scope for radiation workers to have introductory seminars on radiation safety before they start working with radiation.

Conclusion: Working in the radiology department has several types of safety risks, which can be barred or compact if manage suitably. Informally with these types of risks and their penalty, agreement with policy and strategy on work ecological safety, and expansion of a traditions that supports supervision, treatment, and on time conduct will go far toward civilizing overall employee security for all employees in the radiology department.
Identification, Prevention and Treatment of Drug Toxicity in the Primary Care Settings
Authors: Al Yamani Abrar Abdulfattah , Alhoshan Faisal Musaad , Alhamidah Ali Salem , Albalawi Ghada Saleh , Almalki Saeed Abdullah , Alanazi Asrar Abdalh , Alassiri Abdullah Mohammed , Alasmari Abdulaziz Saud , Albaharna Aqeelh Mohammed , Aloufi Anwaar Saud , Hussain Arwa Abdulmajid
Published: January 2022

Studies from global countries indicate that poisoning is a common etiology for morbidities and associated mortality. Most of the cases did not require medical intervention as they were treated at home. However, around one-fourth required management at a healthcare facility. In addition to the healthcare burdens, evidence indicates that these events also have significant economic burdens on the affected patients and healthcare facilities. The present literature review provided evidence regarding the proper ways to identify patients presenting with suspected medication poisoning and the recommended management approaches. Obtaining a complete history from the patient should be the first step that can lead to diagnostic clues. Then, a thorough examination should be provided, followed by relevant imaging and laboratory studies to confirm the diagnosis. Management might be supportive in many cases, and an antidote can enhance the treatment process. Approaches should also be conducted to achieve decontamination and enhance the elimination of the affected patients.
Pharmacognostical Profile of Gymnema sylvestre and its Anti-Hyperglycemic Activity
Authors: Sehajpal Sorabh , Saraswat Rohit , Verma Neetu
Published: January 2022

In this paper explored the pharmacognostical profile of gymnema sylvestre and its anti-hyperglycemic activity has been documented well with references. The importance of the species in Ayurveda has been highlighted. The bioactive components like gymnema sylvestre has a variety of secondary metabolites, including oleanane, gymnemic acid, gymnemasides (A-F), gymnemic acid (IXVIII) homologue, gymnemic acid A1 and its derivatives, triterpenoidsaponin, al has been clearly includedin the review kaloid (Conduritol-A), polypeptide (Gurmarin), and gymnemasaponins. This study has provided the groundwork for developing a pharmacognostical profile of medicinal plant growers and collectors. The goal of this review study is to provide a regional profile of the indigenous knowledge system for medicinal plant usage and cultural behaviors related to healing. This study aids in the identification of novel ethnomedicinal plant species in the study region, which may lead to the development of new medicines. The plant toxicity test results indicated that it may be used as an alternative to diabetes therapy with no or little adverse effects. This study confirms the conventional use of indigenous plant-derived natural medicine for treating diabetes mellitus. The study also highlighted the efficacy of "Ayurveda" which is an ancient tradition, used in some parts of India. This ancient concept should be carefully evaluated in the light of modern medical science and can be utilized partially if found suitable. I hope that this kind of research will be useful to future researchers as per their needs.
A Case Report: Post-Operative Physiotherapy Rehabilitation Program for a Patient with Tibial Osteosarcoma
Authors: Dhote Sapna , Bawiskar Dushyant , Phansopkar Pratik
Published: January 2022

Tumour or bone tumour can occur in any bone and called it as a Osteosarcoma. It is more prone in the long bones of the body especially at metaphyseal growth plate of the bone. Femur, Tibia and Humours are the most common bone for the osteosarcoma and in some research pelvis bone and skull or jaw bone also involved. There are many factors which cause the sarcoma might be due lack of physical activity. The Chondroblastoma as Giant Cell Tumour of the Humours of Epiphysial Chondromatous in nature. Proximal humerus and Knee are the most common and most affected bone by the Chondroblastomas at the level of epiphyses of the longer bone. 62% cases show the thinning of the Subchondral structure and 33% cases shows the collapse and chondral breach Mostly (90%) it is found in the age group of 5 to 25 years of age with the male and female ratio is of 2:1. Psychological and physical improvement is seen in the patient of sarcoma and enhances participation in the exercise with great enthusiasm and help in the reduction the impact of symptoms of diseases. Physical therapy exercise protocol starts from low to moderate intensity which involved resistance exercise, aerobic exercise and combination of both exercises.

Conclusion: Physiotherapy has been demonstrated to be useful in post-operative osteosarcoma patients in our case study. Physiotherapy assists the patient in de-stressing from both mental and physical stress. The goal of improving function through health-care management and goal-setting was met on schedule. Taking excellent care of yourself after surgery can help you avoid issues.