bluuebunny/crossref_metadata_2025 huggingface dataset:
Morena en las elecciones de 2022: tsunami, diques y olas electorales
Authors: Navarrete Vela Juan Pablo , Rosiles Salas Javier
Published: May 2024

El presente artículo analiza las seis elecciones subnacionales de 2022. Se parte del supuesto de que las victorias de Morena no se pueden considerar como un tsunami electoral, pero sí como olas gobernantes y contraolas opositoras. En cada estado se examina el contexto político y se revisan los datos electorales comparados, es decir, se toma como marco de referencia las elecciones de 2016 versus las de 2022. Para ubicar el rendimiento electoral de todos los partidos en competencia, se examinan los datos de las elecciones federales de 2018, 2021 y 2022, esto para determinar el voto duro de cada partido y los territorios con presencia de los siete partidos con registro nacional. Además, se muestran indicadores como el porcentaje de votos, promedio, margen de victoria y concentración electoral
La accesibilidad a los servicios públicos desde la representación política: revisión de literatura en América Latina
Authors: Lara Escalante Mónica María , Puente Martínez Khemvirg
Published: May 2024

El artículo tiene como objetivo analizar la literatura sobre la accesibilidad a servicios públicos desde un punto de vista de representación territorial. Durante mucho tiempo la representación política se estudiaba desde el punto de vista de la elaboración de políticas públicas. En este estudio se parte de una concepción multidimensional, tomando también en cuenta la distribución de recursos y servicio al distrito. Además, previamente se había estudiado el caso estadounidense, sin embargo, en América Latina existe evidencia de que es un fenómeno importante, por lo que resulta fundamental revisar los estudios para la región. Se identifican condiciones institucionales, partidarias, individuales y características del distrito que influencian la responsividad hacia el distrito electoral
Experimental Study on Workability, Strength & Durability of Geopolymer Concrete with use of Fly ash, Ground Granulated Blast Furnace Slag & Silica Fume
Authors: Vagadiya Jeet
Published: May 2024

Abstract: Geopolymer concrete, crafted from a blend of Fly Ash, GGBS, and Silica Fume activated by sodium silicate and sodium hydroxide, demonstrates excellent workability and strength over time. It proves resilient against acid, chloride, water absorption, and carbonation, making it a sustainable choice for construction projects seeking durability and performance. These qualities position geopolymer concrete as a promising alternative to traditional concrete methods.
Anchorage Zone Stress Mapping using ANSYS
Authors: Dixit Ajinkya Shrikant
Published: May 2024

Abstract: This paper presents a comprehensive analysis of stress development in the anchorage zone of prestressed posttensioned concrete beams using the finite element method with ANSYS. Focusing on both concentric and eccentric loading scenarios, the study varies the loaded area ratio (k) to investigate its effect on stress distribution. The obtained results are meticulously compared with existing literature, enhancing understanding of the behaviour of anchorage blocks within prestressed concrete members. Beyond stress assessment, the study evaluates the performance and structural integrity of the anchorage zone, providing valuable insights for design optimization and construction practices.
Comparative Analysis of Traditional Methods and Building Information Modeling (BIM) in Construction Project Cost Estimation
Authors: Deore Siddharth Prabhakar , Joshi Dr. Deepa A.
Published: May 2024

Abstract: Building Information Modeling (BIM) has revolutionized the construction industry by providing digital images of the physical and functional aspects of the site. This article explores the use of BIM in project management and compares it to traditional methods. The study focused on parameters such as efficiency, cost, accuracy, and coordination. Research shows that BIM increases efficiency, accuracy, and coordination while reducing costs and risks. However, challenges remain, such as developing regulations and reaching consensus on requirements among stakeholders. Despite these challenges, the article concludes that BIM has the potential to transform project management.
Effects of a social norms intervention to reduce alcohol drinking behaviors in Argentinean adolescents
Authors: Pautassi Ricardo Marcos , Michelini Yanina , Pilatti Angelina , Rivarola Montejano Gabriela , Badino Manuel , Gigena-Parker Darío , Caneto Florencia , Bonino Pablo
Published: May 2024

Alcohol-related social norms are internalized beliefs regarding the extension and approval of alcohol consumption by social reference groups. Prevention programs based on social norms and behavioral insights are empirical evidence-based approaches that challenge cognitive biases and promote healthy choices by providing actual information of targeted behaviors. These programs, to our knowledge, have not been applied to reduce alcohol use in Latin-America. Objectives: This study examined the effectiveness of a school-based social norms intervention to reduce alcohol use behaviors in high-school adolescents from Cordoba city (Argentina). Ninety-two students (Mean age = 14.18±0.82 years) participated. A 2 (type of school administration: public, private) x 2 (treatment: experimental, control) factorial design was employed. Data collections provided information on actual alcohol consumption, perceived alcohol consumption of classmates and discrepancies (i.e., biases) between both measures. Results: A brief feedback session, which was complemented with the placement of posters inside the classroom, reduced the prevalence and frequency of several alcohol drinking behaviors. These effects were more noticeable in the public than in the private schools. Conclusions: This is, to our knowledge, the first report of a program that applied a social norms strategy to reduce alcohol consumption in high schoolers from South America.
Amplifying informal science learning: rethinking research, design, and engagement
Authors: Walker Graham J.
Published: May 2024

An intriguing book on informal science learning in all its cultural and geographic diversity, deftly balancing theory, practice and the wondrous space in-between.
Freshwater algae Cladophora glomerata and Vaucheria sp. from Serbia as sources of bioactive compounds: Chemical analysis and biological activities
Authors: Stefanovic Olgica , Rakonjac Aleksandra , Nikodijevic Danijela , Milojevic Sara , Dinic Anica , Simic Snezana
Published: May 2024

We examined potential biological activities of two taxa of freshwater algae, Cladophora glomerata and Vaucheria sp., from Serbia. The total phenolic and pigment contents, antioxidant potential, antimicrobial, antibiofilm activities, and cytotoxicity of the ethanol and acetone extracts were evaluated. The extracts were also subjected to Fourier transform infrared spectroscopy (FTIR) analysis. The levels of total phenolic compounds, chlorophylls a and b, and carotenoids varied based on both the algal taxa and the type of extracts. FTIR analysis showed the presence of lipids, unsaturated fatty acids, protein, carbohydrates, and phenols in the algal extracts. The extracts had moderate DPPH radical scavenging activity and lower reducing power compared with ascorbic acid. The antimicrobial activity expressed as minimum inhibitory concentrations ranged from 0.31 mg/mL to 10 mg/mL. The strains of Staphylococcus aureus and Bacillus cereus isolated from food samples, as well as S. aureus ATCC 25923, were the most sensitive. For the first time, the antibiofilm activity test revealed 98.7% inhibition of S. aureus biofilm formation. The extracts exhibited cytotoxic effects on choriocarcinoma JAR cells but without selectivity on normal fetal lung fibroblast MRC-5 cells. This is the first report on the biological activities of freshwater macroalgae from Serbia.
ANALISIS OVERREACTION HYPOTHESIS PADA HARGA SAHAM
Authors: Radiyanti Eka , Hasnawati Sri
Published: May 2024

The purpose of this research is to see if there is an overreaction hypothesis on stock prices on the Indonesia Stock Exchange. This study's population consists of 229 manufacturing companies registered on the Indonesia Stock Exchange between 2018 and 2022. This study's sample was drawn using a purposive sampling approach, yielding a sample of 127 companies. The study used a significance t test which was processed using SPSS 22 software. The research period is an annual period. Shares are classified into 2 types, namely winner stocks and loser stocks. The results of the study show that winner and loser stocks have experienced several reversals, but these symptoms cannot be proven statistically. As a result, there is no overreaction hypothesis for manufacturing companies registered on the Indonesia Stock Exchange between 2018 and 2022.
Keywords: Overreaction Hypothesis, Winner Stocks, Loser Stocks, Abnormal Return
Design of A Semi-Automatic Banana Chips Slicing Machine to Reduce Musculoskeletal Disorders (MSDS) In Workers
Authors: Aprillova Carmelita Virry Clarissa , Ekoanindyo Firman Ardiansyah
Published: May 2024

This research aims to improve the banana chip-slicing process at Aneka Keripik Clarissa'N UMKM. The slicing is done manually, leading to workers' discomfort and Musculoskeletal Disorders (MSDs). To address this, we are designing a new machine based on the Nordic Body Map (NBM) questionnaire results. This machine, tailored using workers' anthropometric data, aims to be ergonomic, reducing fatigue and enhancing comfort and efficiency in the slicing process. The goal is simplifying and speeding up production while ensuring maximum worker well-being. Keywords: Anthropometrics, MSDS, Nordic Body Map, Tool Design
Optimizing New Product Development in The Hijab Industry: A House of Risk Analysis on Marketing and Design Process
Authors: Wijaya Muhammad Agusta , Handayani Dwi , Basuki Demas Emirbuwono , Mukarim Rifki Nurul
Published: May 2024

XYZ Company, a Micro, Small, and Medium Enterprise (MSME) based in Yogyakarta, specializes in producing hijabs but faces challenges in maintaining customer interest due to a misalignment between product designs and consumer preferences. To address this, the company actively engages in new product development (NPD), focusing on trend analysis and model innovation to cater to customer needs better. An essential part of minimizing risks during the NPD process involves evaluating and identifying potential pitfalls, particularly in marketing and design. This study employs the Hazard and Operability Review (HOR) method to assess risks systematically. Initial findings from HOR phase 1 reveal that inadequate competitor information (A3) leads to significant risks in competitor product identification (E3), contributing approximately 70.34% to the total Aggregate Risk Priority (ARP). Subsequently, in HOR phase 2, XYZ Company prioritizes ten mitigation actions, with conducting a comparative study of competitors' products (PA1) being the most critical, reflected by an ETDk value of 540. Keywords: House of Risk (HOR), Hijab Fashion, Hijab Industry, New Product Development (NPD)
Analysis Of Customer Satisfaction With Packaged Drinking Water Products Using Service Quality (SERVQUAL) And Importance Performance Analysis (IPA) Methods
Authors: Maulana Muhammad Helmi , Nuruddin Moch.
Published: May 2024

PT. XYZ is a bottled mineral water manufacturer in Gresik, striving to deliver customer satisfaction and stay competitive. This study aims to quantify consumer satisfaction with PT. XYZ's product quality. We collected data through a questionnaire and analyzed it using the Servqual method and Importance Performance Analysis (IPA). The questionnaire included nine quality attributes, categorized into five dimensions. IPA was utilized to prioritize service quality attributes. The Servqual method revealed a negative gap, indicating suboptimal service. The Cartesian IPA diagram highlighted two critical areas for improvement: enhancing staff interaction during service and improving personnel demeanor, specifically their politeness, and friendliness. These improvements are vital as they align with consumer expectations and are essential for enhancing overall service quality at PT. XYZ. Keywords: Service Quality, Importance Performance Analysis (IPA), SERVQUAL
Quality Control Analysis of Painting Results in Steel Construction Projects Using Statistical Quality Control Methods and Failure Mode Effect Analysis at PT. BSB
Authors: Romadhoni Abrori , Dahdah Said Salim
Published: May 2024

PT BSB is a company engaged in construction specialising in steel fabrication. There are various projects carried out at the company, namely bridges, steel structures, buildings, towers, and others. The research was conducted to analyse the quality of results in the painting process at PT BSB using statistical quality control (SQC) and failure mode effect analysis (FMEA) methods. Data collection is done by collecting primary and secondary data used in this study. The four types of painting defects obtained from the research results are Sagging/Runs, Orange Peel, Pin Hole and Seeds/Dirt. Based on the FMEA method, the level of defects can be determined based on the cumulative percentage value produced, where the highest defect value is 1750 Sagging/Runs defects. One of the factors causing the defect is the uneven spraying of paint, causing a layer of paint that is too thick, resulting in excessive accumulation of paint in certain parts that flow vertically and unevenly. From this research, it can be concluded that the company must use the SQC method to determine the causes of defects in the painting process and analyse improvements that must be prioritised. Keywords: Failure Mode Effect Analysis (FMEA), Painting Process Analysis, Statistical Quality Control (SQC)
Analysis Risk K3 Using JSA and HIRARC Methods Phosphoric Acid Factory on PT. Petrokimia Gresik
Authors: Rozikin Muhammad Khoiru , Hidayat Hidayat , Rizqi Akhmad Wasiur
Published: May 2024

PT. Petrokimia Gresik is one of the industries that produce fertilisers, non-fertilizers, and other chemicals. PT. Petrokimia Gresik is divided into several departments, including the phosphoric acid factory. This research aims to identify and reduce potential hazards during the production process. This research uses (JSA) method to identify the hazard stage and (HIRARC) method to conduct risk analysis. Based on the risk hazard identification results, each job will be assessed based on severity and likelihood to establish the risk level. The research found that all extreme-risk jobs had 4 risks, high risks had 15 risks, medium risks had 2 risks, and no jobs with low-risk levels were found. The control plan carried out in this study is to control by elimination, engineering, administration, and personal protective equipment (PPE). Keywords: Occupational Health Safety, JSA, HIRARC.
Increasing Customer Satisfaction with Quality Function Deployment Methodology Based on Service Quality Analysis
Authors: Vazry Johan , Hidayat Hidayat , Negoro Pandu Yanuar
Published: May 2024

One way to be superior to competing companies in the service field, especially customer satisfaction, is by analyzing service quality. Satisfied customers can increase their loyalty and have more trust in a company, so they can continue using its services. PT. XYZ is a company that offers logistics accommodation services; this research took the period from January 2023 to February 2024. It is known that the number of fluctuating customers tends to decrease. Apart from that, there were also several complaints submitted by customers, including products arriving late, inability to fulfill customer requests, delays in the delivery process, and top payments not being evenly distributed. This research used the Servqual and Quality Function Deployment (QFD) methodology. The Servqual method was carried out by distributing questionnaires to 95 respondents to identify the biggest gaps based on the dimensions of tangibles, reliability, assurance, empathy, and responsiveness, which was then carried out with a QFD analysis to determine the priority of corrective action. based on technical response. The research results show that the reliability dimension has the largest gap value, 0.21. A QFD analysis is carried out objectively to determine quality improvement based on technical responses obtained from customers' voices. In the QFD analysis, it is known that the priority corrective actions that must be taken are carrying out correct transaction recording, faster employee processes, increasing employee skills, increasing security, optimizing the system, and increasing availability. Keywords: Customer Expectations, Customers Satisfaction, House of Risk, Service Quality, Quality Function Deployment
IMPROVING THE QUALITY OF ORTHOPEDIC DENTISTRY TEACHING USING INNOVATIVE TECHNOLOGIES
Authors: Havaleshko Vasyl , Roshchuk Oleksandra
Published: May 2024

The need to implement innovative technologies and create a student- oriented environment in a higher medical school is determined by the challenges of time to create a motivated, active student – a future competitive specialist.The purpose of our study was to analyze the features of innovative methods used in teaching orthopedic dentistry and to choose directions for further optimization of the educational process. A number of research methods were used to fulﬁ ll the set goal: the bibliosemantic method with the processing of literature sources and electronic resources, methods of analysis, synthesis, generalization, comparison and systematization. Also a number of cases regarding the application of innovative technologies for teaching the discipline «Orthopedic Stomatology» at the Department of Prosthetic Dentistry of Bukovinian State Medical University were highlighted.Modern students perceive the interactive technologies, visualization of educational material with an individually diﬀ erentiated approach much better. Of the interactive methods when studying orthopedic stomatology, we use the PRES method, brainstorming, discussion, working in small groups, situational modeling, and the case method most often. Adherence to the algorithm when performing practical skills and simulation technologies allow students to acquire eﬀ ectively the competencies provided by the program, as well as successfully pass the OSCE.Therefore, improving the organization of the educational process in the discipline «Orthopedic dentistry» using innovative teaching methods allows providing high-quality education to dental students. The introduction of a student- centered educational environment, on the one hand, helps to form competent, creative, proactive personalities of future dentists, but, on the other hand, requires teachers to continuously improve their own methods of teaching the discipline, acquire new skills based on the principles of facilitation, and create new simulation scenarios and their thorough training with students on a powerful material and technical base.
IMPLEMENTASI PENGUATAN PERILAKU WIRAUSAHA SISWA MELALUI PROGRAM MARKET DAY DI SD NEGERI 3 ADIPASIR, BANJARNEGARA
Authors: Citra Mukti Restiana , Andriani Ana
Published: May 2024

Education  is an important place for the formation of student behavior and character.  Market day  is present as a form of implementation of entrepreneurial learning that supports aspects of student competence that are instilled through entrepreneurial values. This research was conducted at SD Negeri 3 Adipasir Rakit, Banjarnegara using a qualitative approach method aimed at describing the implementation of strengthening students' entrepreneurial behavior. The research results show that the  market day  program is a strong foundation for strengthening entrepreneurial behavior. The planning stage is the main foundation, where students are invited to formulate ideas, produce goods, set goals, and develop implementation strategies.  Market day  forms various entrepreneurial attitudes. Students demonstrate independence, creativity, leadership, honesty, curiosity, discipline, cooperation and innovation during activities.  Market day  is not only an ordinary school event, but also a forum for strengthening students' character and entrepreneurial skills.
El cuidado de sí: palabra y cuerpo en la formación de profesora/es de Educación Física
Authors: Pich Santiago , Mezzaroba Cristiano , Turelli Fabiana Cristina , Maciel Alceu Junior , Moraes Letícia Baldasso , Jacó Paulo César de Carvalho
Published: May 2024

El ensayo problematiza la idea moderna de formación de profesores de educación física referenciada en la noción de cuidado de sí a partir de la elaboración de Michel Foucault. Ese movimiento nos lleva a pensar la relación entre cuerpo y verdad que es constitutiva del modo hegemónico de formación de profesores construida con base en el par pedagogía-profesor(a) y a cuestionar la imposibilidad de la formación del sujeto ético en ese registro en el contexto de una política democrática. Por otro lado, con base en el concepto de cuidado de sí y en el par psicagogía-parresiasta elaboramos algunos principios que nos permiten construir otro modo de formación docente en el campo de la educación física, que tienen como clivaje la constitución del sujeto ético para la vida en común.
El sujeto consciente de sí en la relación del deporte y la educación, con la seguridad y la pobreza. Traza de una lógica conservadora
Authors: Cardozo Giles Liber Ismael
Published: May 2024

Objetivo: El artículo examina la intersección entre políticas de seguridad y políticas educativas para el caso uruguayo, en ocasión de ciertas prácticas de gobierno que toman al deporte como herramienta. Para tal cometido estudiamos un programa llevado adelante por el Ministerio del Interior, denominado Pelota al medio a la esperanza. Tal análisis se procura centrar en la categoría de sujeto consciente de sí, y su estrecho vínculo con la propiedad privada como bien sagrado de la sociedad capitalista. Método: Examinaremos un conjunto de entrevistas realizadas a informantes claves del Programa, Coordinadores/as, Profesores/as de Educación Física, Psicólogas/os, que han diseñado y puesto en marcha las actividades del mismo. A su vez, analizamos un conjunto de versiones taquigráficas del Parlamento uruguayo en las que se discutieron asuntos relacionados a la Seguridad Ciudadana. Resultados: Adelantamos que hay ciertos elementos discursivos que se pueden observar en las prácticas de gobierno asociadas a la educación y la seguridad, que son comunes al universo político uruguayo. Conclusiones: Pudimos concluir que la noción de sujeto consciente de sí y su vínculo con la propiedad privada, es un común denominador que subyace los discursos políticos y educativos, haciendo lazo en la relación entre seguridad y educación.
signos e as coisas
Authors: Cunha e Silva Luiz Felipe
Published: May 2024

A partir da formulação do teórico da arquitetura Kenneth Frampton, de que o ato de construir é mais ontológico do que representacional, e de que a forma construída é antes uma presença do que uma representação e, também de sua afirmação de que, na terminologia de Martin Heidegger, um dos expoentes da fenomenologia alemã, poderíamos pensar a forma construída mais como coisa do que como signo, coloca-se alguns textos da obra deste filósofo sob escrutínio, buscando encontrar neles a face tectônica do linguístico e a face linguística do tectônico. Ao fundo dessas discussões, faz-se presente a tensão entre o poético e o instrumental, nas obras de arquitetura. Para a apresentação do objeto da discussão e definição de seus contornos foi adotado o método dialógico, ou a maiêutica socrática. Para a condução da dessa discussão, a análise conceitual comparada.
Experiências-limite em estruturas arquitetônicas e artísticas contemporâneas
Authors: Araujo Mariany Silva Gomes , Arantes Pedro Fiori
Published: May 2024

A partir de obras que conjugam arte e arquitetura, este ensaio procura discutir meios pelos quais a percepção contemporânea pode ser turvada e ofuscada quando lida com estruturas históricas de amplos efeitos subjetivos, sociais e políticos. Duas obras, produzidas no início do século XXI e promotoras de experiências próprias a uma era de indeterminação, trabalham tais efeitos alegoricamente: as imersivas Blur Building, de Elizabeth Diller e Ricardo Scofidio, e Weather Project, de Olafur Eliasson. Frente à instabilidade desenfreada do contemporâneo, procura-se, assim, pensar suas possíveis manifestações por meio de obras que, carregadas de ambiguidades, conformam alegorias que podem ajudar a decifrar um sistema vigente e expansivo em um contexto global.
Analisis aflatoksin pada pakan ayam buras dengan metode Enzyme-Linked Immunosorbent Assay (ELISA)
Authors: Zainuddin Dhea Nanda , Hafsan Hafsan , Rukmana Rusmadi , Wirawan Hadi Purnama
Published: May 2024

Aflatoksin, senyawa toksin yang umumnya dihasilkan oleh jamur Aspergillus, dapat membahayakan kesehatan hewan dan manusia melalui produk-produk hewani terkontaminasi. Penelitian ini mengevaluasi tingkat kontaminasi aflatoksin pada pakan ayam buras menggunakan metode Enzyme-Linked Immunosorbent Assay (ELISA). Mini riset dilaksanakan di Laboratorium Patologi Balai Besar Veteriner Maros, Sulawesi Selatan. Pendekatan analitik kuantitatif dengan metode deskriptif digunakan untuk menyelidiki konsentrasi aflatoksin dalam sampel. Hasilnya menunjukkan nilai absorbansi sampel dan konsentrasi aflatoksin ketiga sampel pakan ayam buras menunjukkan kandungan aflatoksin berbeda, namun semuanya berada di bawah batas maksimum 20 ppb sesuai Standar Nasional Indonesia (SNI) 3144:2015. Metode ELISA terbukti efektif dan dapat diandalkan dalam mendeteksi aflatoksin dengan tingkat sensitivitas tinggi. Kesimpulan penelitian ini menegaskan bahwa ELISA adalah alat yang efektif untuk memantau kontaminasi aflatoksin dalam pakan ayam buras. Meskipun hasil saat ini memenuhi standar keamanan, pendekatan preventif dan pemantauan terus-menerus tetap penting untuk menjaga kesehatan ternak dan keamanan hasil ternak. Pengembangan metode analisis yang lebih inovatif di masa depan akan memperkuat upaya deteksi dini dan pencegahan optimal dalam penyediaan pakan yang aman dan berkualitas tinggi.
Simulation and experimental study of the thermal characteristics of a high-speed motorized spindle
Authors: Zhang Wei , Jiang Huaqiao
Published: May 2024

Based on the finite element simulation software ANSYS Workbench, this study reports the thermal characteristics of a high-speed motorized spindle. The temperature field distribution and axial thermal deformation of the motorized spindle are then detected on an experimental platform. A comparison between the experimental and simulation results revealed the temperature rise of the motorized spindle during the working process. Under steady-state conditions of the working mo-torized spindle, the temperatures of the front bearing, rear bearing and stator were determined as 20°C, approximately 30°C and 25°C, respectively. The axial thermal elongation of the motorized spindle is approximately 10 μm.
Experimental investigation and performance prediction of SAH using different arc rib roughness geometries – A comparative study
Authors: Singha Jitendra , Lanjewara Atul
Published: May 2024

This study aims to investigate and compare the thermal performance of a solar air heater using a passive technique to enhance heat transfer between the absorber plate and the flowing fluid. The technique involves generating turbulence near the heat transferring surface through the use of artificial rib roughness. The study focuses on two different novel roughness geome-tries: full symmetrical arc rib roughness and half symmetrical arc rib roughness. By introducing additional gaps and varying the number of gaps in the roughness geometries, the study examines their effects on the solar air heaters thermal performance. The artificially roughened surface creates different turbulent zones, which are essential to the development of different types of turbulence in the vicinity of the heat transferring surface. The study finds that an optimal escalation in Nusselt number and friction factor by 2.36 and 3.45 times, respectively, occurs at certain gap numbers as 6 and ng as 5 for full symmetrical arc rib roughness. The maximum thermal-hydraulic performance parameter of 1.66 is attained at a Reynolds number of 6 000. The study also conducts correlation, mathematical modeling, and performance prediction under different operating circumstances.
Validation of a bupropion, dextromethorphan, and omeprazole cocktail for simultaneous phenotyping of cytochrome P450 2B11, 2D15, and 3A12 activities in dogs
Authors: Martinez Stephanie E. , Jimenez Tania E. Perez , Court Michael H.
Published: May 2024

OBJECTIVE

Develop a cytochrome P450 (CYP) phenotyping cocktail for dogs using specific substrates for hepatic P450 enzymes CYP2B11, CYP2D15, and CYP3A12 and determine whether alternative sampling methods (saliva and urine) or single time point samples could be used instead of multiple blood sampling.

ANIMALS

12 healthy client-owned dogs (8 females and 4 males) from February 2019 to May 2019.

METHODS

In a randomized crossover study, dogs received oral administration of the probe drug bupropion (75 mg), dextromethorphan (30 mg), or omeprazole (40 mg) alone or as a 3-drug combination (Program in Individualized Medicine [PrIMe] cocktail) to evaluate simultaneous phenotyping of CYP2B11, CYP2D15, and CYP3A12. Pharmacokinetic profiles for the probe drugs and metabolites were determined using plasma, saliva, and urine. Dogs received probe drugs alone or combined. Pharmacokinetic profiles up to 6 hours postdose for the probe drugs and metabolites were determined using plasma, saliva, and urine.

RESULTS

The PrIMe cocktail was well tolerated. There was no statistically significant interaction between the probe drugs when administered together. Single time point plasma metabolic ratios at 4 hours postdose for all probe drugs strongly correlated with the corresponding area under the plasma concentration-versus-time curve (AUC) ratios. Saliva AUC metabolic ratios for CYP3A12 and CYP2D15 and 6-hour urine for CYP2B11 and CYP2D15 were correlated with plasma AUC ratios.

CONCLUSIONS

The PrIMe cocktail can be used for simultaneous CYP phenotyping using plasma 4-hour single time point sample metabolic ratios. Saliva and urine sampling are suitable for specific CYPs.

CLINICAL RELEVANCE

The PrIMe cocktail has potential as a useful tool in dogs to detect clinically important CYP-mediated drug-drug interactions, identify novel pharmacogenes, determine the drug-metabolizing phenotype of individual dogs, aid in individualized dose selection, and evaluate the effects of various physiological states on drug metabolism.
Penetrating wood foreign bodies (stob) of the coronary band in horses: 15 cases
Authors: Trostle Steven S. , Santos Marcos Antonio Poddis dos , Stephens Paul R.
Published: May 2024

OBJECTIVE

To retrospectively report the historical and clinical findings, diagnostics, treatment, and outcome of horses with penetrating wood foreign bodies (PWFBs) of the coronary band.

ANIMALS

15 client-owned horses.

CLINICAL PRESENTATION

Horses had varying degrees of lameness and soft tissue swelling of the coronary band and pastern region. A defect in the coronary band was identified, but the actual wood foreign body was not always readily visualized.

RESULTS

Medical records of horses diagnosed with PWFBs of the coronary band between 2004 and 2023 were reviewed. Information retrieved from the medical records included history, signalment, diagnostics, treatment, and outcome. Thirteen of 15 horses that sustained a PWFB to the coronary band were participating in foxhunting. Penetrating wood foreign bodies occurred more frequently near the central axis or toe region (11/15) and more commonly in the forelimbs (11/15). Removal of PWFBs can be performed with the horse standing and sedated with regional anesthesia. Complete removal of the PWFB required partial removal of the adjacent hoof wall.

CLINICAL RELEVANCE

Penetrating wood foreign bodies occurred in the coronary band and lodged distally in the hoof wall of horses. Foxhunting may be a risk factor for this type of injury. Penetrating wood foreign bodies occurred most commonly in the front feet, near the central axis of the coronary band. Complete removal of the PWFB required removing a section of the adjacent hoof wall. The prognosis for return to the previous level of activity following treatment was favorable.
Successful surgical management of a Salter-Harris type I fracture of the accessory carpal bone in a dog
Authors: Vardanega Mark , Ralphs S. Christopher
Published: May 2024

OBJECTIVE

To describe the successful surgical management of a previously unreported Salter-Harris type I fracture of the accessory carpal bone in a dog.

ANIMAL

An 11-week-old intact female Golden Retriever–Poodle cross presented with a history of a marked left forelimb lameness following a suspected fall from a height.

CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES

On physical examination, the patient demonstrated a severe left forelimb lameness and pain on palpation and range of motion of the left carpus. Orthogonal radiographs of the distal left forelimb demonstrated a type I Salter-Harris fracture of the accessory carpal bone with proximal displacement of the palmar fragment.

TREATMENT AND OUTCOME

The patient underwent open reduction and internal fixation wherein the fracture was reduced and stabilized with two 1.1-mm Kirschner wires. Postoperatively, the patient was initially managed with a carpal flexion bandage for 2 weeks and then a soft padded bandage was maintained until 4 weeks postoperatively. The patient recovered well and was walking and weight-bearing comfortably following removal of the carpal flexion bandage. Repeat radiographs performed 4 and 8 weeks postoperatively demonstrated adequate fracture healing but showed mild proximocaudal implant displacement. Implant removal was not performed, as the patient was doing well at home and the implant migration appeared static and was not causing clinical morbidity.

CLINICAL RELEVANCE

To the authors’ knowledge, this was the only reported case of a Salter-Harris fracture of the accessory carpal bone in a dog and the only described case of successful surgical stabilization.
Experimental investigation of stereolithography and digital light processing additive manufactured pallets
Authors: Bairapudi Anil , Sastry C. Chandrasekhara , Krishnaiah J. , Sundeep Dola , Eswaramoorthy KV
Published: May 2024

Pallets are a tertiary form of packaging used for stacking, storing, protecting, or transporting goods in supply chains. They are utilized as a base for the unitization of goods for logistics and warehousing. Moreover, pallets can be manufactured using wood, plastic, metal, and corrugated paper, which can be used as material-handling equipment. With several products being transported worldwide and with year-on-year growth, it would be beneficial to make lightweight pallets. Such pallets are recyclable, easy to clean, cheap, and durable to maintain and store. Though most of the pallets are widely available for basic purposes, applications involving high-end bio-packings and transportation of special chemicals require specialized pallets to be manufactured like polymers to ensure a negligible chemical reaction, light in weight, and attenuation in freight capacity, thereby widespread reduction in wastage. With advancements, job to job and immediate requirements, additive manufacturing has the potential to close the gap for jobs with short lead times. If the design process of new pallets has limits the creation of specific codes, the transitions will be smoother in rapid prototyping. This work describes the development of polymer pallets by taking advantage of stereolithography (SLA) and digital light processing (DLP) technology for 3D printing pallets in correlation to injection moulding. After the pallets are designed and manufactured, AM technologies can be applied to specified standards, and the pallets then undergo tensile strength, elongation, and hardness tests. The analysis was carried out for configurable geometries adapting to fork lifting, conveyor, racking, and stacking conditions. Analytical and numerical solutions were carried out to understand the stress and deflections for each geometry and its wide range of applications for pallets.
Comparative analysis of microstructure and selected properties of WC-Co-Cr coatings sprayed by high-velocity oxy fuel on S235 and AZ31 substrates
Authors: Jonda Ewa , Myalska-Głowacka Hanna , Łatka Leszek , Szymański Krzysztof , Dziekońska Magłorzata
Published: May 2024

The purpose of this work was to carry out comparative studies of WC-Co-Cr coatings deposited using the high velocity oxy fuel (HVOF) method onto two types of substrate material: structural steel S235 and magnesium alloy AZ31. The influence of the substrate material type on the microstructure, phase composition, crystallite size, porosity, Vickers microhardness, instrumental hardness (HIT), Young’s modulus (EIT), and fracture toughness was investigated. For both substrates, the deposited coatings deposited were characterized with fine-grained and compact microstructure. The X-ray diffraction (XRD) revealed presence of following phases: WC, W2C, Co0.9W0.1, and Co3W9C4. The WC phase was the most desirable and stable one with crystallites were below 100 nm. On the other hand, the size of the W2C crystallites was below 30 nm. The coatings obtained showed porosity values equal to 2.3 ± 0.4 vol% and 2.8 ± 0.7 vol% for AZ31 and S235, respectively. The average Vickers microhardness for both types of sample was appproximately 1200 HV0.3. The average HIT values for carbide particles and metallic matrix were around 29 GPa and 6.5 GPa, respectively. In the case of EIT, it was around 620 GPa and 190 GPa for WC and Co-Cr, respectively. The differences between coatings were negligible. The EIT value for both coatings was equal to 344 ± 11 GPa. The fracture toughness was around 4.5 MPa · m1/2 in both cases. The investigations revealed that it is possible to replace steel substrate material with a much lighter equivalent, in this case AZ31 alloy, without deterioration of the coating properties.
Effects of infill density on mechanical properties of additively manufactured chopped carbon fiber reinforced PLA composites
Authors: Mayandi K. , Rigesh K. , Nagarajan Rajini , Ismail Sikiru O. , Krishnan Kumar , Mohammad Faruq , Al-Lohedan Hamad A.
Published: May 2024

In this present study, the fused deposition modeling (FDM) method was used to fabricate the composites. Before three-dimensional (3D) printing, samples were designed according to the ASTM D256, D790 and D3039 standards for impact, flexural and tensile tests, respectively, using Onshape software before conversion to an STL file format. Afterward, the digital file was sliced with infill densities of 60%, 80%, and 100%. The composite samples contained chopped carbon fiber (cCF) and poly lactic acid (PLA), as reinforcement and matrix, respectively. The cCF/PLA (simply called cCFP) filaments were printed into various cCFP composite (cCFPC) samples, using a Viper Share bot 3D machine with different infill densities before the aforementioned mechanical testing. The tensile strength of cCFP were obtained as 25.9MPa, 26.9MPa and 34.75MPa for 60%, 80% and 100% infill density cCFP samples, respectively. Similarly, the flexural strength of cCFP were obtained as 11.8MPa, 12.55MPa and 18.4MPa and impact strength was 47.48kJ/m2, 48.45kJ/m2 and 48.96kJ/m2 for 60%, 80% and 100% infill density cCFP samples, respectively. The fractured/tested samples were examined and analyzed under a scanning electron microscope (SEM) to investigate the presence of fiber and void in the tensile sample. Based on the experimental results, it was evident that a high infill density of 100% with the highest reinforcement exhibited maximum impact strength, tensile and flexural strengths and moduli when compared with other lower carbon content of cCFPC samples. Therefore, the optimal 3D-printed cCFPC sample could be used for engineering application to benefit from properties of the polymer matrix composite materials and possibilities through additive manufacturing (AM).
Enhanced catalytic activity of zeolitic imidazolate frameworks (ZIF-8) polyelectrolyte complex composites membranes by laser etching
Authors: Yu Ting , Kitiyanan Boonyarach , Dubas Stephan Thierry
Published: May 2024

The effect of laser etching on the surface properties of composite polyelectrolyte complex (PEC) based membranes as mixed matrix membranes was studied. The PECs were prepared by the stoichiometric mixing of cationic PDDA (poly(diallyl dimethyl ammonium chloride)) and anionic PSS (poly(sodium 4-styrene sulfonate)) as polyelectrolytes with various contents of ZIF-8 as filler. Composite membranes usually display improved bulk properties depending on the nature of the filler, but the surface properties are often dictated by the matrix covering the surface. The PEC composite membranes were then subjected to laser etching, resulting in the enhanced exposure of embedded ZIF-8 particles within the PEC structure in an attempt to improve the surface properties of the composite membrane. The crystal structure, morphology, and distribution of zinc at the PECs surface, before and after laser etching, were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and energy-dispersive X-ray spectroscopy (EDS), respectively. In order to evaluate the improvement of the surface properties of the laser-etched membranes, a model experiment involving a catalytic reaction was chosen. The pristine and laser treated surfaces were tested for their catalytic activity for the transesterification of triglycerides present in soybean oil with methanol at a temperature of 150°C. Interestingly, the laser-etched PECs displayed substantially enhanced activity compared to the original composite PEC membranes as a result of surface erosion. These results could be interesting for the future development of composite membranes with improved surface properties where the filler needs to expose the surface of the membranes.
Everyday Outdoor Music Life in Galician Cracow
Authors: Woźna-Stankiewicz Małgorzata
Published: May 2024

The paper characterises music-involving cultural practices in Cracow’s urban parks, squares, streets, and ice rinks in the period of the so-called Galician Autonomy (1866–1918). Typologies of the spaces where music was performed and of open-air events involving music have been proposed. Music repertoires and performers have been discussed. The main sources for this text are press materials, memoirs, regulations, sheet music, and iconography.
Entrepreneurial Coaching: Contributing to The Performance and Curbing the Obstacles to Innovation of Small and Medium Enterprises in Africa
Authors: Imane Mouhtat , Fatima Touhami , Salma Ibenchekroun , Hamza Melliani
Published: May 2024

Introduction: Innovation is a catalyst for business development, particularly for small businesses. However, the majority of African SMEs fail to adopt an innovation strategy.
 
Aim: The aim of this work is to analyze the obstacles to innovation in an African context, with an analysis of the importance of the entrepreneurial support variable.
 
Method: The method used in this work is a quantitative analysis by questionnaire. Our sample consists of 120 African small and medium-sized enterprises. Data analysis will be carried out using multiple linear regressions.
 
Contributions: The contribution of this article is the analysis of the entrepreneurial support variable for innovation adoption.
 
Results: The results of our paper, using multiple linear regressions, show the importance of the potential customer variable for investment in innovation. Entrepreneurial support, and specifically network integration, provides financial capacity, access to markets and administrative facilities, variables that are positively correlated with the adoption of an innovation strategy.
Symmetric and Asymmetric Association Between Foreign Direct Investments and Macroeconomic Variables: An Ardl Approach
Authors: Jaiswal Krishna Kumar , Kumar Nand
Published: May 2024

Objectives: The main objective of the study is to investigating the dynamic relationship between FDI and different Macro Economic Variables (MEVs) using the ARDL procedure, providing a more comprehensive understanding of the association between FDI and MEVs and to evaluate their relative importance for FDI.
 
Methods: This study utilizes annual data from 1991 to 2021 from the World Bank (2021) and the Reserve Bank of India (2021). Data on GDP, Export, Inflation and interest rate, and FDI are collected from the World Bank. Autoregressive Distributive lag Model procedure has been used for the study in order to establish relationship between Macro economic variables and FDI.
 
Results: Our methodological approach using ARDL model and finds: (a) a positive correlation between exports and FDI, (b) a negative impact of inflation and exchange rates on FDI in the long run. Non-linear ARDL analysis reveals the asymmetric impact of inflation and interest rate on FDI, which includes the effect of positive and negative shock of interest rate and inflation on FDI. d) 1% increase in inflation reduces FDI by 0.4% and if Inflation is reduced by 1%, FDI is increased by 0.2%. At the same time, the non-linear estimation of interest rates concludes that there is an asymmetric and significant association between interest rates and FDI. e) If Interest rate has increased by 1% FDI is decreased by 0.9% and if interest rate has reduced by 1% FDI has deceased by 1.63%. f) The causality analysis reveals that exports, GDP, and exchange rates are the significant economic variables that affect FDI.
 
Conclusion: The study's findings have practical implications for policymakers and investors looking to attract more FDI in India. The results indicate that exports play a critical role in attracting FDI and that the government should focus on improving export performance to increase FDI inflows. Additionally, the study highlights the importance of controlling inflation and exchange rates to attract more foreign investment. The finding that interest rates have an asymmetric relationship with FDI suggests that policymakers should be cautious when implementing monetary policies that may impact interest rates. Overall, the study provides valuable insights for policymakers and investors looking to attract more FDI in India and highlights the importance of considering the country's macroeconomic conditions when making investment decisions.