bluuebunny/crossref_metadata_2025 huggingface dataset:
Maximizing Value of Information of a Horizontal Polymer Pilot Under Uncertainty
Authors: Steineder Dominik , Clemens Torsten , Osivandi Keyvan , Thiele Marco
Published: April 2018

Polymer injection might lead to incremental oil recovery and increase the value of an asset. Several steps have to be taken to mature a polymer injection project. The field needs to be screened for applicability of polymer injection, laboratory experiments have to be performed, and a pilot project might be required prior to field implementation.

The decision to perform a pilot project can be based on a Value of Information (VoI) calculation. The VoI can be derived by performing a workflow capturing the impact of the range of geological scenarios as well as dynamic and polymer parameters on incremental Net Present Value (NPV). The result of the workflow is a Cumulative Distribution Function (CDF) of NPV linked to prior distributions of model parameters and potential observables from the polymer injection pilot.

The impact of various parameters on the CDF of the field-wide NPV can be analyzed and in turn used to decide on what measurements from the pilot have a strong sensitivity on the NPV CDF and are thus informative. In the case shown here, the water cut reduction in the pilot area has a strong impact on the NPV CDF of the polymer injection field implementation. To extract maximum information, the response of the pilot for water cut reduction needs to be optimized under uncertainty.

To calculate the VoI, the Expected Monetary Value (EMV) difference of a decision tree with and without the pilot can be used if the Decision Maker (DM) is risk neutral. However, if the DM requires hurdle values through a Probability of Economic Success (PES), Value Functions (VF) and Decision Weights according to the Prospect Theory should be used. Applying risk hurdles requires a consistent use of VFs and Decision Weights for calculating VoI and the Probability of Maturation (POM) of projects.
Calculation of Relative Permeability Using Well Test Data in Gas-Condensate Reservoirs
Authors: Al Abdulwahab Ibrahim , Jamiolahmady Mahmoud , Whittle Tim
Published: April 2018

Analysing well test data from gas-condensate reservoirs can be challenging, particularly when pressure drops below the dew point and condensate forms near the well. Usually, a single-phase pseudo-pressure approach is used to analyse the corresponding pressure transient well test data in combination with a composite reservoir model, but this approach has its shortcomings. A two-phase pseudo-pressure approach has been shown to give better results, but it requires relative permeability (kr) data which are not readily available.

The paper demonstrates the reliability of calculating a pressure versus radius profile from pressure versus time build up data from tests on wells in gas-condensate reservoirs. The calculation is based on the probe radius concept originally proposed for single-phase systems. It also evaluates the possibility of obtaining, analytically, kr data affected by pressure and velocity in single-rate and multi-rate tests. The calculation is based on Darcy's law using the pressure derivative with respect to distance obtained from the pressure versus radius profile. The theory of these calculations is verified by comparing the results with the output from a numerical simulator based on a single-layer single-well radial reservoir model. A simple binary rich gas condensate fluid was used in the numerical simulation.

The results demonstrate that the pressure versus radius profile using probe radius theory reasonably matches the corresponding pressure versus radius profile output from the numerical simulation. This also shows that the method can reliably predict the condensate bank radius. At first, the analytical approach used to calculate kr, as a function of radius, resulted in oscillations due to the nature of derivative calculation involved. The source of the kr noise was treated following two separate approaches that can be used depending on the level of noise versus ease of use. The calculated kr versus radius data showed good agreement with the corresponding grid block kr versus radius data predicted by the simulator for various rock types and flow rates.

The method described in this paper provides a practical tool to estimate kr data that can be used to calculate two-phase pseudo pressure and hence potentially improve the analysis of gas-condensate test data affected by condensate banking and velocity. The derived kr data may also have other applications.
Prenylated Coumarins of the Genus Citrus: An Overview of the 2006- 2016 Literature Data
Authors: Genovese Salvatore , Taddeo Vito A. , Epifano Francesco , Fiorito Serena
Published: April 2018

O-Prenyl coumarins (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic
derivatives) represent a class of rarely occurring natural products. In the last two
decades, such secondary metabolites have been found to possess promising and effective
pharmacological properties, mainly in terms of anti-cancer and anti-inflammatory properties.
To date, about 160 oxyprenylated coumarins have been extracted from plants, fungi,
and bacteria. The genus Citrus has been demonstrated to be among the richest source of
the title products. The aim of this comprehensive review is to make a survey of the so far
reported literature citations about the main O-prenyl coumarins found in this genus from
phytochemical and pharmacological point of views and for which no surveys of the in so
far reported literature have been made.
Dopaminergic Neuroprotection with Atremorine in Parkinson´s Disease
Authors: Carrera Ivan , Fernandez-Novoa Lucia , Sampedro Carolina , Tarasov Vadim V. , Aliev Gjumrakch , Cacabelos Ramon
Published: April 2018

Patients with Parkinson’s disease (PD) are looking forward to new therapeutic
strategies that may gradually decelerate the rate of neurodegenerative decline, associated with
mobility restrictions and related morbidity. Its continuous neurodegenerative process, exacerbated
by genetic mutations or environmental toxins, involves a progressive reduction in the
dopamine neurotransmission levels, synaptic uptake density, oxidative glucose intake, deficient
striatal lactate accumulation and chronic inflammation. Over the last decade, novel bioproducts
have received considerable interest due to their unique potential of unifying nutritional,
safety and therapeutic natural effects. Some nutraceuticals play a crucial role in the
control of the signaling transduction pathways in neurotransmission and inflammation affected
in PD, and some natural compounds can beneficially interact with each one of these biological
mechanisms to slow down disease progression. Atremorine, a novel plant-derived
nutraceutical, probably with a neuroprotective effect in the dopaminergic neurons of the substantia
nigra (pars compacta), is a prototype of this new category of bioproducts with potential
effects in PD. The major focus of this review will be on the current knowledge and biomedical
investigation strategies through a plant-derived neuroprotective approach to improve life
quality in PD patients, being of paramount importance for health providers, caregivers and the
patients themselves.
Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards
Authors: Oliveira Justine P.R. , Melendez-Ortiz H. Ivan , Bucio Emilio , Alves Patricia Terra , Lima Mayara Ingrid Sousa , Goulart Luiz Ricardo , Mathor Monica B. , Varca Gustavo H.C. , Lugao Ademar B.
Published: April 2018

Safety and biocompatibility assessment of biomaterials are themes of constant concern as
advanced materials enter the market as well as products manufactured by new techniques emerge.
Within this context, this review provides an up-to-date approach on current methods for the characterization
and safety assessment of biomaterials and biomedical devices from a physical-chemical to a
biological perspective, including a description of the alternative methods in accordance with current
and established international standards.
Development and Certification of Formononetin Reference Material for Quality Control of Functional Foods and Botanical Supplements
Authors: Gong Ningbo , Zhang Baoxi , Hu Kun , Gao Zhaolin , Du Guanhua , Lu Yang
Published: April 2018

Background:

Formononetin is a common soy isoflavonoid that can be found abundantly in
many natural plants. Previous studies have shown that formononetin possesses a variety of activities
which can be applied for various medicinal purposes. Certified Reference Materials (CRMs) play a
fundamental role in the food, traditional medicine and dietary supplement fields, and can be used for
method validation, uncertainty estimation, as well as quality control.

Methods:

The purity of formononetin was determined by Differential Scanning Calorimetry (DSC),
Coulometric Titration (CT) and Mass Balance (MB) methods.

Results:

This paper reports the sample preparation methodology, homogeneity and stability studies,
value assignment, and uncertainty estimation of a new certified reference material of formononetin.
DSC, CT and MB methods proved to be sufficiently reliable and accurate for the certification purpose.
The purity of the formononetin CRM was therefore found to be 99.40% ± 0.24 % (k = 2) based on the
combined value assignments and the expanded uncertainty.

Conclusion:

This CRM will be a reliable standard for the validation of the analytical methods and for
quality assurance/quality control of formononetin and formononetin-related traditional herbs, food
products, dietary supplements and pharmaceutical formulations.
30. sympozjum biblistów polskich w Łomży (1992)
Authors: Hałas Stanisław , Skoczylas Henryk
Published: April 2018

—
Przygotowanie Eucharystii niedzielnej (aspekt teologiczno-pastoralny)
Authors: Pisarzak Marian
Published: April 2018

—
Dysertacje o tematyce biblijnej i liturgicznej na Wydziale Teologicznym Uniwersytetu Jagiellońskiego w latach 1945–1954
Authors: Piech Stanisław
Published: April 2018

—
Janowy Kościół a teologia czwartej Ewangelii
Authors: Gryglewicz Feliks
Published: April 2018

—
XVI Kongres Biblistów Polskich
Authors: Matras Tadeusz
Published: April 2018

—
Psałterz w wersji Jana z Czarnolasu
Authors: Peter Michał
Published: April 2018

—
In memoriam dom Bernard Botte († 1980)
Authors: Nadolski Bogusław
Published: April 2018

—
Modlitwa „osiemnastu błogosławieństw”
Authors: Mendecki Norbert
Published: April 2018

-
KS. MARIAN FILIPIAK, Człowiek współczesny a Stary Testament, Lublin 1982
Authors: Chmiel Jerzy
Published: April 2018

-
50 lat Katolickiego Dzieła Biblijnego w RFN
Authors: Tomczyk Dominik
Published: April 2018

—
CAEREMONIALE EPISCOPORUM, ex Decreto Sacrosancti Oecumenici Concilii Vaticani II instauratum, auctoritate Ioannis Pauli PP. II promulgatum, Editio Typica, Typis Polyglottis Vaticanis 1984
Authors: Durak Adam
Published: April 2018

—
DZIEJE PRZYMIERZA. Biblia dla młodzieży. Warszawa 1985
Authors: Grzybek Stanisław
Published: April 2018

—
Aramejska inskrypcja wróżbity Balaama syna Beora
Authors: Lemaire André
Published: April 2018

—
Życie i działalność ks. Jeana Carmignaca (1914-1986)
Authors: Kapera Zdzisław Jan
Published: April 2018

—
Rozwój proroctwa o Emmanuelu jako przykład hermeneutyki w Starym Testamencie
Authors: Strus Andrzej
Published: April 2018

—
The Old Testament in Syriac, according to the Peshitta version, part II, fasc. 1a: Job, Leiden 1982
Authors: Woźniak Jerzy
Published: April 2018

—
Nielewickie kapłaństwo królestwa Izraela
Authors: Brzegowy Tadeusz
Published: April 2018

—
Sprawozdanie prezesa Polskiego Towarzystwa Teologicznego w Krakowie za rok 2001
Authors: Panuś Kazimierz
Published: April 2018

—
Zanim otworzysz Biblię, pod red. ks. Michała Peterai ks. Mariana Wolniewicza, Poznań 1981
Authors: Grzybek Stanisław
Published: April 2018

-
Teksty liturgiczne jako źródło medytacji
Authors: Miazek Jan
Published: April 2018

-
Sprawozdanie z obrad muzyków kościelnych
Authors: Pawlak Ireneusz
Published: April 2018

-
Krajobraz w aspekcie teologicznym
Authors: Zielniok Marian
Published: April 2018

-
Biblijne podstawy pokuty
Authors: Chmiel Jerzy
Published: April 2018

-
CARDINAL A. RENARD, Trois chrétiens adultes, Paris 1980
Authors: Koperek Stefan
Published: April 2018

-
H. LANGKAMMER OFM, Maryja w Nowym Testamencie, Gorzów Wielkopolski 1991,
Authors: Chmiel Jerzy
Published: April 2018

-
Język gestów w Starym Testamencie
Authors: Wojciechowski Michał
Published: April 2018

—
Najnowsze rozwiązania problemu synoptycznego
Authors: Bartnicki Roman
Published: April 2018

—
KS. KAZIMIERZ GRELA, Konkordancja Nowego Testamentu, cz. I: A–Ó, cz. II: P–Ź, Polskie Towarzystwo Teologiczne, Kraków 1987
Authors: Chmiel Jerzy
Published: April 2018

—
„Postępujmy w światłości Jahwe” (Iz 2, 5) – proroctwo o prawdziwym rozbrojeniu „Ambulemus in lumine Yahweh” (Is 2, 5) – prophetia de vera dcsarmatione
Authors: Cholewiński Alfred
Published: April 2018

—
Post w życiu Jezusa Chrystusa
Authors: Dąbek Tomasz Maria
Published: April 2018

—
Prorocka posługa Kościoła w świetle biblijnej koncepcji Słowa Bożego
Authors: Ogrodzki Jan
Published: April 2018

—
FRANZ kard. HENGSBACH, Ich, der Mit.lteste, Essen 1974
Authors: Grzybek Stanisław
Published: April 2018

—
Człowiek obrazem Boga według Jana Chryzostoma
Authors: Włodarczyk Stanisław
Published: April 2018

—
Odznaczenie ks. prof. Feliksa Gryglewicza (w osiemdziesięciolecie urodzin)
Authors: Ordon Hubert
Published: April 2018

—
Śp. ks. Feliks Szreder CR (1914–1989)
Authors: Micewski Bolesław
Published: April 2018

—
J. A. FITZMYER SI, Luke the theologian. Aspects of his teaching, New York 1989
Authors: Pietrusiak Paweł
Published: April 2018

—
X Colloquium biblicum (Wiedeń 1998)
Authors: Chmiel Jerzy
Published: April 2018

—
Tematy rozpraw doktorskich z zakresu biblistyki
Authors: Matras Tadeusz
Published: April 2018

—
Recepcja soborowej konstytucji liturgicznej Sacrosanctum Concilium (Kamień Śląski 1999)
Authors: Nowakowski Przemysław
Published: April 2018

—
Ze świata biblijnego
Authors: Gliński Efrem
Published: April 2018

—
Św. Antoni z Padwy, Doktor Ewangeliczny
Authors: Gustaw Romuald
Published: April 2018

—
Święto Wniebowzięcia Najświętszej Marii Panny a sprawa dogmatu mariologicznego
Authors: Florkowski Eugeniusz
Published: April 2018

—
Udzielanie komunii św. podczas mszy św. i poza mszą św.
Authors: Sitkowski Tadeusz
Published: April 2018

—
Pieśń dziękczynna
Authors: Klawek Aleksy
Published: April 2018

—
Jezusa Chrystusa „kazanie na górze” (Mt 5, 1–7, 29; Łk 6, 20–49). Komentarz i rozważania (dokończenie)
Authors: Zawadzki Józef
Published: April 2018

—
Obchody ku czci ks. Jakuba Wujka
Authors: Grzybek Stanisław
Published: April 2018

—
Niebo i ziemia niechaj Pana chwalą. Psalm 148
Authors: Klawek Aleksy
Published: April 2018

—
Historyczność zmartwychwstania Chrystusa w listach św. Pawła
Authors: Stefaniak Ludwik
Published: April 2018

—
Objaśnienie odnośnie czynności liturgicznych podczas „Świętego Tridum” zgodnie z odnowionym porządkiem Wielkiego Tygodnia
Authors: Kongregacja Obrzędów Święta
Published: April 2018

—
Motu proprio Indulty uzupełniające Konstytucję apostolską „Christus Dominus”
Authors: XII Pius
Published: April 2018

—
Pierwszy międzynarodowy Kongres Duszpasterstwa Liturgicznego w Asyżu
Authors: Małaczyński Franciszek
Published: April 2018

—
Odpowiedzi św. Kongergacji Obrzędów z dnia 16 czerwca 1956 r. na zapytania i wątpliwości związane z interpretacją Dekretu De rubricis ad simpliciorem formam redigendis z dnia 23 marca 1955 roku
Authors: Szwagrzyk Tadeusz
Published: April 2018

—
Poetyckie przekłady pojedynczych psalmów XIX w.
Authors: Waliczek Kazimierz
Published: April 2018

—
Sacra Rituum Congregatio de usu grammophonii et de horis mixtis in ecclesiis
Authors: Szwagrzyk Tadeusz
Published: April 2018

—
Czy Chrystus miał braci?
Authors: Grzybek Stanisław
Published: April 2018

—
Dopuszczenie obcego kapłana do ołtarza
Authors: Szwagrzyk Tadeusz
Published: April 2018

—
Bronię „Bogurodzicy”
Authors: Bajerowa Irena
Published: April 2018

—
O co właściwie chodzi?
Authors: Groblicki Julian
Published: April 2018

—
Zmiany w kodeksie rubryk
Authors: Kongregacja Obrzędów Święta
Published: April 2018

—
Człowiek jako świątynia w nauce Nowego Testamentu
Authors: Pytel Jan
Published: April 2018

—
Ewangelia dziecięctwa p. Jezusa a krytycy
Authors: Rumak Jerzy
Published: April 2018

—
Pierwsze proroctwo (Gen 3, 14–19)
Authors: Klawek Aleksy
Published: April 2018

—
Homilia liturgiczna
Authors: Świerzawski Wacław
Published: April 2018

—
Wspomnienie o ks. Józefie Ricciottim
Authors: Chmiel Jerzy
Published: April 2018

—
Epoka proroka Aggeusza
Authors: Peter Michał
Published: April 2018

—
Znaczenie pielgrzymki Pawła VI
Authors: Grzybek Stanisław
Published: April 2018

—
Tworzywo pojęciowe i literackie doktryny św. Pawła Apostoła
Authors: Stefaniak Ludwik
Published: April 2018

—
60-lecie kapłaństwa o. Wincentego Rejmera OFM Ref.
Authors: Klawek Aleksy
Published: April 2018

—
Mojżesz – jego wielkość
Authors: Łach Stanisław
Published: April 2018

—
Esjon-Geber (nowe umiejscowienie portu króla Salomona na Morzu Czerwonym)
Authors: Ziółkowski Zenon
Published: April 2018

—
Święto NMP Wspomożenia Wiernych w 150-lecie
Authors: Kuźmak Krystyna
Published: April 2018

—
Godzina biblijna. Osiem błogosławieństw
Authors: Klawek Aleksy
Published: April 2018

—
Skuteczność „ex opere operato” mszy świętej i sakramentów i jej stosunek do „opus operantis”
Authors: Bieda Ignacy
Published: April 2018

—
Wokół projektu ekumenicznego tłumaczenia Biblii
Authors: Chmiel Jerzy
Published: April 2018

—
Doktrynalne i teologiczne podstawy katolickiej sakramentologii
Authors: Wawrzyniak Franciszek
Published: April 2018

—
Śpiew i muzyka w obrzędach chrztu dzieci
Authors: Pawlak Ireneusz
Published: April 2018

—
Ekumeniczny przekład Listu do Rzymian
Authors: Szymanek Edward
Published: April 2018

—
Którzy jesteśmy słowem Bożym
Authors: Maliński Mieczysław
Published: April 2018

—
Materiały biblijne do homilii adwentowych
Authors: Chmiel Jerzy
Published: April 2018

—
Bibliografia prac księdza Aleksego Klawka (1890–1969), profesora U. J. K. i U. J.
Authors: Kapera Zdzisław J.
Published: April 2018

—
La confirmation. Que dire? Que faire? Recherches actuelles, Lyon 1972
Authors: Krakowiak Czesław
Published: April 2018

—
Biblia w oczach dziecka. Refleksje na temat plastycznej ekspresji dziecka i jej związków z przyswajaniem treści wiary
Authors: Rodziński Stanisław
Published: April 2018

—
WALTER ZIMMERLI, Grundriss der alttestamentlichen Theologie, Stuttgart 1975
Authors: Grzybek Stanisław
Published: April 2018

—
KS. FELIKS GRYGLEWICZ, Ewangelia według św. Łukasza. Wstęp – przekład z oryginału – komentarz, Poznań–Warszawa 1974
Authors: Grzybek Stanisław
Published: April 2018

—
Orkiestra króla Nabuchodonozora II czy zespół Antiocha IV Epifanesa? Kilka uwag muzykologa
Authors: Kubies Grzegorz
Published: April 2018

The article is an attempt to answer two questions set at the beginning of the article about the instruments and the origin of the band described in the book of Daniel 3: 5, 7, 10 and 15. After short historical remarks, the current knowledge about the instruments mentioned in the book of Daniel is presented. To all of the seven terms (for comparative purposes) Greek and Latin equivalents were added, as well as the etymology. In case of the disputable terms the most important hypothesis were put forward, forming (more than once erroneously) mainly through the translational practice an image of the musical scene.In the next part, first the Hellenic (2nd century B. C.) and then – supported by the author – Mesopotamian (6th century B. C.) hypothesis about the origin of the band are discussed. The subject of the article is set in the context of the reflections on the musical cultures of ancient Greece and Mesopotamia. The musicological discourse is based in the first place on the preserved iconographical evidence and, to a lesser degree, on the stationery one. Five modern Polish translations of Daniel 3: 5, 7, 10 and 15 and a comment on them form the final part of the article.
Przekaz wiary a włożenie rąk w obrzędach katechumenatu
Authors: Fedorowicz Szymon
Published: April 2018

—
JAN KANTY PYTEL, Słowo Boże nie jest związane. Uroczystości, Święta. Dni okolicznościowe, Pallottinum, Poznań 1998
Authors: Dąbek Tomasz Maria
Published: April 2018

—
XIII Międzynarodowe Spotkanie „Society of Biblical Literature” (Budapeszt 1995)
Authors: Brzegowy Tadeusz
Published: April 2018

—
Sympozjum liturgiczne w Bambergu (1995)
Authors: Boguniowski Józef Wacław
Published: April 2018

–
IX Colloquium biblicum (Wiedeń 1996)
Authors: Pisarek Stanisław
Published: April 2018

—
Problemy posoborowej dyskusji nad urzędem w Kościele
Authors: Rusecki Marian
Published: April 2018

—
Drugie sprawozdanie z prac zespołu redakcyjnego dla opracowania ogólnopolskiego śpiewnika kościelnego
Authors: Mrowiec Karol
Published: April 2018

—
Historia zbawienia według św. Mateusza
Authors: Hergesel Tomasz
Published: April 2018

—
What the Health? Information Sources and Maternal Lifestyle Behaviors (Preprint)
Authors: Dalhaug Emilie Mass , Haakstad Lene Annette Hagen
Published: April 2018

BACKGROUND

Regular physical activity (PA), adequate gestational weight gain (GWG), and healthy eating are important for the long-term health of both mother and baby. Hence, it is important that women receive current and updated advice on these topics and are encouraged to adopt a healthy lifestyle during pregnancy.

OBJECTIVE

The aim of this study was to investigate the main information sources among pregnant women regarding PA, GWG, and nutrition as well as to evaluate how these information sources may affect their health behaviors.

METHODS

A cross-sectional study design, comprising an electronic questionnaire, was distributed to 2 antenatal clinics, as well as pregnancy-related online chat forums and social media. The inclusion criteria were ≥18 years, ≥20 weeks gestation, and able to read and write Norwegian. In total, 150 pregnant women answered the questionnaire, which was a mix of 11-point Likert scales, close-ended questions, and semi–close-ended questions with the option to elaborate. The relationship between information sources and selected variables, including health behaviors and descriptive variables, were assessed by logistic regression, linear regression, or chi-square as appropriate (P<.05).

RESULTS

Mean age (years), gestation week, and prepregnancy body mass index (kg/m2) were 31.1 (SD 4.3), 30.6 (SD 5.9), and 24.2 (SD 4.2), respectively. More than eight out of 10 had received or retrieved information about nutrition (88.7%, 133/150) and PA (80.7%, 121/150), whereas 54.0% (81/150) reported information on GWG. When combining all 3 lifestyle factors, 38.5% had retrieved information from blogs and online forums and 26.6%, from their midwife or family physician. Women who reported
the internet and media as their primary source of information on weight gain had increased odds of gaining weight below the Institute of Medicine (IOM) guidelines compared with gaining within the guidelines (odds ratio [OR] 15.5, 95% CI 1.4-167.4; P=.02). Higher compliance with nutritional guidelines was seen among those who cited the internet and media as their main source of information on nutrition (beta=.7, 95% CI 0.07-1.3; P=.03). On the other side, receiving advice from friends and family on weight gain was significantly associated with gaining weight above the IOM guidelines compared with gaining within the guidelines (OR 12.0, 95% CI 1.3-111.7; P=.03). No other associations were found between information sources and health behaviors.

CONCLUSIONS

The small number of health professionals giving information and the extensive use of internet- and media-based sources emphasize the need to address the quality of internet advice and guide women toward trustworthy sources of information during pregnancy. The association between information sources and PA, GWG, and nutrition requires further research.
Individualized Web-based Exercise for the Treatment of Depression � a Feasibility Study (Preprint)
Authors: Haller Nils , Lorenz Sonja , Pfirrmann Daniel , Koch Cora , Lieb Klaus , Dettweiler Ulrich , Simon Perikles , Jung Patrick
Published: April 2018

BACKGROUND

Due to the high prevalence of depressive disorders, it is mandatory to develop therapeutic strategies that provide universal access and require limited financial and human resources. Web-based therapeutic approaches fulfill these claims.

OBJECTIVE

The purpose of this study was to assess if a supervised, individualized 8-week web-based exercise program in patients with moderate to severe depressive episodes was feasible, accepted and promising to relieve symptoms.

METHODS

Twenty patients with unipolar depression were recruited and randomly assigned into two groups (1: intervention, exercise program, n=14; 2: control, treatment-as-usual, n=6). At baseline, depressive symptoms were rated via the Quick Inventory of Depressive Symptomatology (QIDS) by the patient him- or herself (QIDS-SR) and a blinded psychiatrist (QIDS-C) and performance diagnostics (lactate analysis, spiroergometry during a treadmill walking test) were conducted. Participants of the intervention group received exercise schedules once weekly with endurance and strength training instructions. Rating of depressive symptoms was repeated after 6-12 days and 8 weeks; performance diagnostics were repeated after 8 weeks, only.

RESULTS

Severity of depression subsided significantly in the intervention group after 8 weeks (median change of QIDS-SR: -5, IQR: -2 to -10), already evident within the first 6-12 days (median change of QIDS-SR: -6, IQR: -2 to -8). During the intervention, participants conducted on average 75 minutes of endurance training (IQR: 63-98) per week or 16 (IQR: 15-21) of 19 recommended endurance units in total. In addition, 9 (IQR: 4-12) of 10 recommended strength training exercise units were conducted during the 8 weeks. Performance diagnostics revealed a significant increase of maximum output in Watt for the intervention group after 8 weeks.

CONCLUSIONS

Our individualized web-based exercise intervention in moderate to severe depression was highly accepted and led to a significant and clinically relevant improvement of depressive symptoms.

CLINICALTRIAL

ClinicalTrials.gov Identifier: NCT02874833
Jordan Field Epidemiology Training Program: Critical Role in National and Regional Capacity Building (Preprint)
Authors: Al Nsour Mohannad , Iblan Ibrahim , Tarawneh Mohammed Rasoul
Published: April 2018

UNSTRUCTURED

Field Epidemiology Training Programs (FETPs) are 2-year training programs in applied epidemiology, established with the purpose of increasing a country’s capacity within the public health workforce to detect and respond to health threats and develop internal expertise in field epidemiology. The Jordan Ministry of Health, in partnership with the US Centers for Disease Control and Prevention, started the Jordan FETP (J-FETP) in 1998. Since then, it has achieved a high standard of success and has been established as a model for FETPs in the Eastern Mediterranean Region. Here we describe the J-FETP, its role in building the epidemiologic capacity of Jordan’s public health workforce, and its activities and achievements, which have grown the program to be self-sustaining within the Jordan Ministry of Health. Since its inception, the program’s residents and graduates have assisted the country to improve its surveillance systems, including revising the mortality surveillance policy, implementing the use of electronic data reporting, investigating outbreaks at national and regional levels, contributing to noncommunicable disease research and surveillance, and responding to regional emergencies and disasters. J-FETP’s structure and systems of support from the Jordan Ministry of Health and local, regional, and international partners have contributed to the success and sustainability of the J-FETP. The J-FETP has contributed significantly to improvements in surveillance systems, control of infectious diseases, outbreak investigations, and availability of reliable morbidity and mortality data in Jordan. Moreover, the program has supported public health and epidemiology in the Eastern Mediterranean Region. Best practices of the J-FETP can be applied to FETPs throughout the world.
STRUCTURE-BASED DOCKING STUDIES TOWARD EXPLORING THE POTENTIAL ANTICANCER ACTIVITY OF MORIN AGAINST NON-MELANOMA SKIN CANCER THERAPEUTIC DRUG TARGETS
Authors: C Anjugam , M Sridevi , Ts Gnanendra
Published: April 2018

Objective: The purpose of this study is to explore the anticancer activity of morin compound against human cyclooxygenase-2 (COX-2) and peroxisome-proliferator-activated receptors (PPARs) isotypes (PPARα and PPARγ) through in silico molecular docking studies.Methods: The 3D structures of human COX-2 complexed with ibuprofen (PDB ID: 4PH9), PPARα complexed with a synthetic agonist (2S)-2-(4- methoxy-3-{[(pyren-1-yl carbonyl) amino] methyl} benzyl) butanoic acid (PDB ID: 3VI8) and PPARγ complexed indomethacin (PDB ID: 3ADX) were retrieved from protein databank. The cocrystallized sites were considered as binding sites, and the docking with morin compound was performed along with their respective cocrystals for each target and compared their interactions and binding affinities.Results: It is observed that the morin compound exhibited better binding energy of -32.9528 kJ/mol against PPARα followed by COX-2 (binding energy: −18.4311 kJ/mol) and PPARγ (binding energy: −17.4228 kJ/mol) when compared to their cocrystallized ligands.Conclusion: The present study suggests that morin compound might serve as potential alternatives in the prevention of skin cancers by showing better activity against PPARα.
ASSESSMENT OF MEDICATION ADHERENCE AMONG PATIENTS WITH HYPERTENSION AND DIABETES MELLITUS IN URBAN FIELD PRACTICE
Authors: R Manikandan , Sri Sai Sudha Nandamuri , M Logaraj
Published: April 2018

Objective: The present study was conducted to assess the medication adherence among patients with hypertension (HTN) and diabetes mellitus in the urban area of Tamil Nadu and to assess the reasons for non-adherence.Methods: A cross-sectional study was conducted in an urban area of Tamil Nadu. A total of 100 subjects were enrolled in the study. The patients are diagnosed with HTN and diabetes was included in the study. Morisky medication adherence scale was used to measure adherence among the selected subjects and each patient’s details were regarding non-adherence was noted. The results were tabulated.Results: In our study, the medication adherence of the patients was 84% and the non-adherence patients were 16%. Medication adherence was found to be more in male (58%) when compared with females (42%). In our study, the reasons for non-adherence include high drug cost was more when comparing other factors. In our study, the patients receiving drugs from the medical shop were more comparing with government and private hospitals.Conclusion: A four-fifth of the subjects is adherence to the prescribed medications. The patients having poor medication adherence due to the high cost of the drug and forgot to take use their medication.
EVALUATION OF IN VITRO ANTHELMINTIC PROPERTIES OF AVICENNIA MARINA LEAVES
Authors: Kondepudi Gana Manjusha
Published: April 2018

Objectives: The purpose of the present study was to determine the anthelmintic properties of chloroform, methanol and aqueous extracts of Avicennia marina leaves on Indian earthworm- Pheretima posthuma. Methods: Three concentrations of each extract (25 mg/ml, 50 mg/ml, and 75 mg/ml) were studied in this activity to determine the time of paralysis (vermifuge) and the time of the death of the worms (vermicidal). Piperazine citrate in the same concentrations was taken a reference standard and normal water was taken as control. The time taken for paralysis and death of the worms was recorded.Results: All the extracts showed dose-dependent and a significant activity was shown at higher concentration (75 mg/ml). Methanolic extract showed peak activity at a concentration of 75 mg/ml.Conclusion: Based on the results it was found that the leaves of A. marina possess vermifuge and vermicidal activities and can be used as an effective anthelmintic.
ASSESSMENT OF PHYSICOCHEMICAL PROPERTIES AND PHYTOCHEMICAL CONSTITUENTS ALONG WITH ANTIBACTERIAL POTENTIAL OF TARENNA POLYCARPA LEAF FRACTIONS
Authors: Barus Bunga Rimta , Sitorus Panal , Masfria Masfria
Published: April 2018

Objective: The aim was to investigate the physicochemical analysis, preliminary phytochemical screening and further evaluation of its antibacterial activity from morbesi-besi (Tarenna polycarpa) leaf ethyl acetate and hexane fractions (HF).Methods: The physicochemical parameters were carried out as per the World Health Organization (WHO) guideline from its ethanolic extract. The phytochemical screening was performed as per Indonesia Pharmacopoeia and conventional method on its ethyl acetate and HF. Ethyl acetate and HF at different concentration were evaluated using agar well diffusion assay.Result: The plant was found to be free from contaminations. Morbesi-besi leaf fractions are composed of flavonoids, glycosides, saponins, tannins, steroids, and triterpenoids. The phytochemical screening showed only ethyl acetate of lotus leaf extract contains the flavonoids. The antibacterials assay showed that ethyl acetate fraction was better than HF from the inhibition zone.Conclusion: From the outcomes of this study, morbesi-besi leaf (T. polycarpa) possess potential antibacterial activity.
IN SILICO ANALYSIS RELATED TO TIGR4 STRAIN IN STREPTOCOCCUS PNEUMONIAE
Authors: Karavadi Balasankar , Suresh Pooja
Published: April 2018

Objective: Numerous current investigations are done on the efficiency of natural components to combat the invasion by Streptococcus pneumoniae – strain TIGR4; the main objective is to propose the most favorable ligand compound that could be effective to target the protein.Methods: The normal segments from the Melissa officinalis are docked against serine/threonine protein kinase (STPK) receptor. The tools and programming utilized are modeler v 9.10 for displaying the protein structure, PubChem compound database to recover the synthetic structure of the ligands. ADMET was used to know the toxicity of the ligands and data warrior and the docking analysis was done by PyRx.Result: The results show that 5-cedranone compounds satisfy the ADMET properties and are more favorable to bind with STPK receptor. The drug score of 5-cedranone is 0.4572 and the m binding energy is −7.9.Conclusions: The amino acid residue for the least binding energy for STPK is Ser 175 and Thr 167. Based on the ADMET analysis, 5-cedranone shows moderate cLogP and cLogS values and we predict 5-cedranone may not produce any side effects.
ROLE OF GUT MICROBIOTA IN LIPID METABOLISM
Authors: Kvit Khrystyna , Kharchenko Viacheslav
Published: April 2018

Researchers have studied the connection between cholesterol and microbiota for a long time. The results of widely published data demonstrate that the relationship between the lipid balance of the blood and the composition of the intestinal microbiota is apparent. The oblective of this study was, we tried to find the path through which this connection is carried out. Furthermore, the aim was to analyze the studies, which demonstrate the decrease of blood lipids as the result of different prebiotics and probiotics prescribtion. Also, the screening of different data from previous years was done for comparing the changes in the pathogenesis.
CHARACTERIZATION OF VARIOUS VIRULENCE PROPERTIES OF DRUG-RESISTANT KLEBSIELLA ISOLATES: AN IN VITRO STUDY AMONG “SUPERBUGS”
Authors: Devrari Jitendra Chandra , Pai Vidya
Published: April 2018

Objective: The objective of this study was to evaluate the various virulence factors among all extended-spectrum beta-lactamase (ESBL)-producing Klebsiella isolates.Methods: Klebsiella species (n=201) isolated from various non-repeated clinical samples from October 2016 to May 2017 were collected and identified by biochemical method and confirmed by BD Phoenix. Antibiotic susceptibility test was performed by Kirby-Bauer disc diffusion method, and ESBL detection was done by combined disc diffusion method. Capsule detection was done by nigrosin dye staining, hypermucoviscosity was done by string test, biofilm was performed by microtiter plate assay, and hemagglutination was performed with human erythrocytes treated with tannic acid.Results: Among 201 ESBL-producing Klebsiella isolates, 63.2 % were multidrug resistance and 24.4% were extensively drug-resistant. Among these isolates, Klebsiella infection is more in older patients. All isolates were (100%) positive for capsule and siderophores production. Of all 201 isolates, 14 (7%) were strong, 61 (30.3%) were moderate, and 104 (51.8%) were weak biofilm producers. Among these isolates, 36 (17.9%) were type 1 fimbriae, 140 (69.7%) were type 3 fimbriae, and only 17 (8.5%) were positive for hypermucoviscosity.Conclusion: Several virulence factors were studied, in which biofilm with fimbriae is the main cause for the resistance of antibiotics. Bacterial resistance profile found to be high with ESBL production and multiple drug resistance in the majority of the Klebsiella isolates, which is a result of improper antibiogram schedule and their virulence property.
ANTIMUTAGENIC ACTIVITY OF BINARA HERBS (ARTEMISIA VULGARIS L.) ETHANOL EXTRACT IN MALE MICE INDUCED BY CYCLOPHOSPHAMIDE
Authors: Meliala Linta , Harahap Urip , Harahap Urip , Dalimunthe Aminah , Dalimunthe Aminah
Published: April 2018

Objectives: This study aims to evaluate the antimutagenic activity of binara herbs (Artemisia vulgaris L.) ethanol extract on male mice.Methods: Binara herbs powder was extracted is used ethanol 96% by maceration, then made into a suspension preparation used 0.5% carboxymethylcellulose with 3 dose variations (100, 200, and 300 mg/kg). Further, the extract was administrated orally in mice for 7 consecutive days. 4 h after the last orally, cyclophosphamide 50 mg/kg IP was injected. 30 h after cyclophosphamide injection, the animals were killed, and the samples of bone marrow were prepared and stained with gems. For each sample, 200 cells of polychromatic erythrocytes (PCE) and the same number of normochromatic erythrocytes (NCE) and the cells containing their micronucleus (MN) were counted using the MN test method in vivo.Results: Cyclophosphamide increased the frequency of MnPCE and decreased cell proliferation (PCE/PCE+NCE). All doses of extracts significantly reduced the frequency of MnPCE (p<0.05). The cell proliferation ratio (PCE/PCE+NCE) was also increased. The most effective dose is 300 mg/kg because it has the greatest ability to decrease the frequency of MnPCE and increase the cell proliferation ratio.Conclusion: Results of this study indicated that binara herbs (A. vulgaris L.) ethanol extract has potent antimutagenic activity.
IDENTIFYING OF HUMAN METAPNEUMOVIRUS AND ITS PHENOTYPE AS A CAUSATIVE AGENTS OF PNEUMONIA IN CHILDREN
Authors: Hussein Al-shebani Abbas Mohammed , Aubaid Adnan Hamad
Published: April 2018

Objectives: The present investigational study was aimed to detect and identify the genotypes of Human metapneumovirus (hMPV) and its phylogeny with respiratory syncytial viruses (RSV) that cause pulmonary inflammation.Material and Methods: A total of 250 samples of patients who were clinically diagnosed respiratory tract illness were collected from Maternity and Children Hospital in Al Diwaniyah city, Iraq. The clinical samples were nasopharyngeal, nasal and throat swabs. The current study screened the presence of hMPV and RSV (A and B) genotypes from nasopharyngeal specimens of children aged from several days to 10 years old.Results: The results revealed that 6% were infected with hMPV, 8% of respiratory syncytial viruses type A (RSV-A) and 14% of respiratory syncytial virus’s type B (RSV-B) from children who are suffering from respiratory illness. Phylogenetic tree analysis of hMPV based on the partial sequences of the fusion protein (F) gene was used for genotyping and detection. The phylogenetic tree was constructed using maximum likelihood tree method in MEGA 6.0 version. The local hMPV isolates (S1) were closely related to NCBI-Blast hMPV genotype A1 (KM408076.1), the local hMPV isolates (S2, S3, and S5) were closely related to NCBI-Blast hMPV genotype B1 (KJ196323.1), and the local hMPV isolates (S4) were closely related to NCBI-Blast hMPV genotype B2 (JQ041689.1).Conclusions: The prevalence rate of hMPV is less than RSV, and both subtypes of hMPV, A and B may exist and circulate in one season, and the predominant sublineage of hMPV shifts in progressive season.
5th International Postgraduate Conference on Pharmaceutical Sciences 2017 (iPoPS 2017)
Authors: Uitm Selangor May Faculty Of Pharmacy
Published: April 2018

WELCOME MESSAGE FROM THE VICE CHANCELLOR OF UNIVERSITI TEKNOLOGI MARA (UiTM)Assalamualaikum wbt I would like to congratulate the Postgraduate Society of Faculty of Pharmacy, UiTM Puncak Alam for organising the 5th International Postgraduate Conference on Pharmaceutical Sciences 2017 (iPoPS 2017).This conference has been successfully organised since 2012 by the postgraduate students together with the Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan without fail. This symbolises the strong collaboration between UiTM and TUS towards academic excellence, which enhances our academic visibility. UiTM has been ranked top 200 in the QS World University Ranking by subject 2017 for Pharmacy & Pharmacology. This is a big achievement for a young faculty of 14 years.On that note, contributions from the postgraduates play an important role in the development of human capital headed for a personified nation with humanistic values, forward thinking with an edge in entrepreneurship. Postgraduate students nowadays not only face challenges in completing their studies but also competing with the fast pace of ever changing technology. Therefore, we need to allow their full integration into the global knowledge society together with international collaboration to advance the quality of higher education worldwide.Participation in event with different cultures and background like iPoPS 2017 helps develop articulate  thinking  and  inspire  healthy  competition  of  ideas  among  the  young,  budding research generation in Malaysia. Hopefully, by continuing to invite eminent speakers from all over  the  world,  the  Conference  will  gain  its  recognition  in  the  international  research community and make UiTM soar upwards.       We trust this Conference will be a success and carry on for years to come. Congratulations!EMERITUS PROFESSOR DATO’ DR. HASSAN SAIDVice-Chancellor Universiti Teknologi MARA (UiTM)
Increasing Persistence of Collage Students in Science Technology Engineering and Mathematic (STEM)
Authors: Zamista Adelia Alfama
Published: April 2018

Penulisan makalah ini didasarkan pada hasil studi literatur, jurnal dan temuan penelitian tentang persistensi dan pendidikan science, technology, engineering, dan mathematic (STEM). Dari hasil kajian teori diketahui bahwa pendidikan STEM merupakan bentuk pendidikan yang paling sesuai untuk mempersipkan generasi yang literasi terhadap STEM demi menjawab tuntutan zaman dan perkembangan teknologi. Namun masih sedikit peserta didik di Indonesia bahkan mahasiswa yang mengambil jurusan teknik yang menyadari pentingnya STEM. Umumnya hal ini disebabkan karena rendahnya persistensi mahasiswa terhadap STEM. Persistensi merupakan kegiatan yang dilakukan secara sukarela untuk mencapai tujuan meski menghadapi berbagai kendala. Persistensi yang tinggi dan positif akan suatu hal sebanding dengan motivasi dan kepercayaan diri seseorang untuk mencapai tujuannya. Berdasarkan kajian teori persistensi yang tinggi dan positif terhadap STEM dan pendidikan STEM akan meningkatkan kualitas proses pembelajaran yang kemudian akan meningkatkan mutu lulusan.
Prevalencia de prescripción inapropiada de terapia supresora de ácido en adultos hospitalizados en un hospital general en Bogotá
Authors: Posada Bustos Sebastian , De León Fernández Nathalia , González Morales Rossmary , Tihanyi Feldman Jonathan , Vera Chamorro José Fernando
Published: April 2018

Objetivo: Determinar la prevalencia de prescripción de terapia supresora de ácido (TSA) conformada por los inhibidores de la bomba de protones (IBP) y los antagonistas de los receptores H2 (AR-H2) en pacientes adultos hospitalizados en el Hospital Universitario Fundación Santa Fe de Bogotá (HU-FSFB) que no corresponda a las indicaciones de las guías de práctica clínica (GPC).Métodos: Estudio observacional descriptivo de corte transversal que incluyó pacientes adultos hospitalizados en el HU-FSFB con prescripción de TSA de novo, determinando las indicaciones de TSA y comparándolas con las indicaciones validadas. Se excluyeron: pacientes con prescripción o consumo previo de TSA durante dos semanas, y pacientes internados en unidad de cuidados intensivos o con hospitalización menor a un día.Resultados: Entre enero y julio de 2015, se incluyeron 306 pacientes con un promedio de edad de 56,6 ( años, con una prevalencia de prescripción de TSA sin indicación basada en la evidencia del 59,5%. Las indicaciones no basadas en la evidencia más comunes fueron: profilaxis sangrado por ulcera gastrointestinal en pacientes de bajo riesgo: 64,9% y causa no establecida en un 13,7%. Se encontró asociación estadísticamente significativa entre tiempo de hospitalización menor a siete días (OR: 2,39 IC 95% 1,4-3,9) y edad menor a 60 años (OR: 1,9 IC 95% 1,2-3,03) con prescripción inapropiada de TSA.Conclusión: Existe una alta prevalencia (59,5%) de prescripción inapropiada de TSA en pacientes adultos hospitalizados con asociación positiva en menores de 60 años y corta hospitalización en el HU-FSFB.