bluuebunny/crossref_metadata_2025 huggingface dataset:
Дослідження впливу скін-ефекту на втрати потужності в системах тягового електропостачання постійного струму
Authors: Плахтій Олександр Андрійович , Нерубацький Володимир Павлович , Шелест Дмитро Андрійович , Цибульник Владислав Романович
Published: December 2021

Наведено дослідження гармонічного складу тягових струмів у залізничній системі електропостачання постійного струму. В дослідженні враховано вплив вищих гармонік, зумовлених несиметрією живильної напруги, гармонік трифазних випрямлячів тягових підстанцій, роботу пасивного гібридного фільтра тягової підстанції, а також вплив вищих гармонік, зумовлених імпульсним споживанням струмів тягових автономних інверторів напруги електрорухомого складу з асинхронним тяговим електроприводом. На прикладі фільтра тягової підстанції ЕЧ-20 регіональної філії «Південна залізниця»      АТ «Укрзалізниця» показано, що неканонічні гармоніки, зумовлені несиметрією живильної напруги, не придушуються існуючими режекторними ланками фільтра. Вплив вищих гармонік електрорухомого складу досліджено на прикладі роботи асинхронного тягового електропривода з вхідним LC-фільтром та автономним інвертором напруги електричного рухомого складу. Дослідження роботи автономного інвертора напруги електрорухомого складу виконано для режимів синусоїдальної широтно-імпульсної модуляції і просторово-векторної широтно-імпульсної модуляції.

Показано, що застосування просторово-векторної широтно-імпульсної модуляції дає змогу  покращити гармонічний склад тягових струмів і знизити їх коефіцієнт гармонічних спотворень. Визначення гармонічного складу та перехідних процесів виконано шляхом комп’ютерного моделювання в програмі Mаtlаb/Sіmulіnk. На підставі визначеного гармонічного складу в контактній мережі наведено дослідження впливу скін-ефекту на розподіл щільності струму в перерізі контактного проводу системи залізничного електропостачання постійного струму. Дане дослідження було виконано також шляхом комп’ютерного моделювання в програмі Аnsys Maxwell. Як результат, скін-ефект викликає збільшення еквівалентного активного опору провідника, що зумовлює збільшення додаткових втрат потужності в контактному проводі систем залізничного електропостачання, викликаних вищими гармоніками тягових підстанцій та вищими гармоніками електрорухомого складу
User Interfaces
Authors: Unzeta Bruno Bueno , de Boer Jan , Delvaeye Ruben , Dernegowski Nikodem , Deroisy Bertrand , Deroisy Bertrand , Fontoynont Marc , Norman Bruce , Pimenta Daniel Neves
Published: December 2021

This report shows, that the impact of a good User Interfaces (UI) is not only affecting the usability and comfort for the user, but is also a major key to save energy. At least as important for effectiveness to the quality of individual interfaces is consistency in the meaning of individual user interface elements (visual, conceptual, auditory, etc.)
La experiencia del teatro digital durante la pandemia por la COVID-19 en Lima
Authors: Rebata Delgado Sofía Magaly
Published: December 2021

La pandemia por la COVID-19 trastornó la convivencia entre humanos y la alternativa frente al distanciamiento social ha sido mantener los vínculos comunicacionales mediante la tecnología. Con ello, se afectó el convivio —en términos de Jorge Dubatti (2015)—, un rasgo sustancial de la identidad del teatro, y se optó por el tecnovivio a través del teatro digital. La definición de teatro digital y la relación —mediada por la tecnología— entre los artistas escénicos y las audiencias se encuentran en construcción, así como su gestión sostenible. Con el objetivo de analizar la experiencia local, se ha revisado la situación del teatro peruano —antes y durante la pandemia— y se han realizado entrevistas semiestructuradas a tres creadores escénicos, quienes tuvieron temporadas en Lima en medio de la crisis sanitaria. A través de los datos cualitativos recogidos, se identifican las fortalezas, las debilidades y los alcances a futuro de este formato.
Percepciones sobre el tránsito a modalidades de enseñanza no presenciales. Un estudio exploratorio entre docentes de educación pública básica en la ciudad de Guadalajara, México
Authors: Chávez Palencia Talía , González Reyes Rodrigo
Published: December 2021

Este estudio exploratorio tiene como finalidad identificar las principales percepciones de docentes de educación pública básica en la ciudad de Guadalajara, México, en torno al proceso de migración a modalidades no presenciales durante el inicio de la pandemia por la COVID-19. La meta general tras el diseño del trabajo empírico fue crear un corte sincrónico sobre la presencia de estas percepciones para poder comparar, en estudios posteriores y a mediano plazo, las posibles oscilaciones en las percepciones entre los mismos docentes y, probablemente, entre otro tipo de actores.
Movimientos feministas en México y sus transformaciones en el contexto de la pandemia por la COVID-19 a partir de las prácticas comunicativas en las redes sociodigitales
Authors: García González Lidia Ángeles
Published: December 2021

El presente artículo es un estudio de corte cualitativo sobre los movimientos feministas en México y sus transformaciones en el contexto de la pandemia por la COVID-19 a partir de las prácticas comunicativas en las redes sociodigitales. Su propósito es conocer los desafíos, los cambios y las estrategias comunicativas empleadas ante el confinamiento, que limitó el uso del espacio público para la protesta feminista y el acompañamiento a mujeres víctimas de la violencia. Asimismo, presenta una discusión teórica sobre los movimientos sociales y la acción colectiva feminista en el contexto de la pandemia ocasionada por la COVID-19 (Della Porta, 2020b; Pleyers, 2021; Tabbush, 2021). Los resultados evidencian cambios significativos en sus estrategias comunicativas en las redes sociodigitales y un incremento en el agotamiento emocional, dado el confinamiento impuesto por la contingencia sanitaria; sin embargo, el empleo de iniciativas locales muestra una perspectiva esperanzadora de volver a retomar las calles en el futuro.
La educación física en la sombra de la pandemia: realidad del Perú
Authors: Torres Paz Luis Edwin , Granados Barreto Juan Carlos
Published: December 2021

En un mundo globalizado, regido por las tecnologías y comunicaciones, la realidad para la educación física es adversa, pues existe una gran brecha de desigualdad que ha dificultado su reinvención equilibrada e inclusiva en el ámbito virtual, a diferencia de lo ocurrido en otras áreas. Asimismo, en algunas instituciones ha desaparecido, en un momento en el que la mejora de los programas de educación física jugaría un papel importante en la prevención de trastornos mentales, el incremento de la salud física y la resiliencia en estudiantes, como lo afirma la Unesco (2019). También, en el Perú, en colegios con Bachillerato Internacional y particulares de elevado costo, las horas de educación física aumentaron, lo que evidencia el reconocimiento de su importancia para menguar el estrés, la ansiedad y el sedentarismo a mediano y largo plazos. Por tanto, se debe evaluar la situación mundial y peruana abordando el aspecto socioeconómico y la enseñanza de la educación física en el contexto de la pandemia y la globalización.
Effects of Direct Additive and Direct Dominance on Litter Traits in Crossbred Sows between Danish Yorkshire and Danish Landrace Pigs in Vietnam
Authors: Tinh Nguyen Huu , Trung Pham Ngoc , Bui Anh Phu Nam
Published: December 2021

Background: The objectives of this study were to estimate the effects of direct additive and dominance on litter traits and to predict the reproduction of un-tested crossbred sows between Danish Yorkshire (Y) and Danish Landrace (L) pigs in Vietnam. Methods: Litter traits data were obtained between 2014 and 2017 in Binh Thang and Khang Minh An breeding farms, with 671 litters of crossbred sows crossed from 1,308 litters of purebred Yorkshire and Landrace sows. Result: In F1 sows, heterosis was manifested in all traits with 6.7-6.4% for TNB; 5.4-6.2% for NBA; 4.4-4.8% for NW and 5.7-6.0% for AWW traits. Additionally, direct dominance was the most positive effect on litter traits in crossbred sows. In rotational crossbred sows of L (YL) and L (LY), while the value of litter traits remarkably decreased in comparison with F1 groups, it was a noticeably higher than that of the purebred sows by 1.4-3.0%. In un-tested crossbred groups of Y (YL) and Y (LY), predicted values for litter traits were equal in tested crossbred groups of L (YL) and L (LY) and lower than F1 crossbred sows.
AL-HAMDULILLAH DALAM AL-QUR’AN (Kajian Terhadap Lafadz Al-Hamdulillah Dalam Fawatih dan Khawatim As-Suwar)
Authors: Quran Jurnal Semiotika , . Ardi
Published: December 2021

Penelitian ini bertujuan untuk mengetahui makna intuitif lafadz hamdalah pada fawatih as-suwar dan khawatim as-suwar serta korelasi di antara ke-duanya. Kemudian metode penelitian yang disajikan dengan jenis penelitian kualitatif menggunakan lokasi datanya (library reasearch), yaitu tela’ah yang dilaksanakan untuk memecahkan suatu masalah yang bertumpu pada penelaahan kritis dan mendalam terhadap bahan-bahan pustaka relevan. Teknik pengumpulan data pada penelitian ini terfokuskan pada penelusuran dan tela’ah dokumen atau sumber data tertulis, baik itu sumber data primer maupun sekunder yang berkaitan dengan pembahasan ini. Kemudian dalam hal ini penulis akan melakukan analisis terhadap ayat-ayat al-Qur’an yang terfokuskan pembahasan penelitian. Adapun hasil dan pembahasannya lafadz hamdalah pada keseluruhan ayat-Nya baik itu pada fawatih maupun khawatim sangat memilki hubungan yang sangat kuat antara iman dan syukur kepada-Nya. Kemudian kesimpulan terkait topik permasalahan mengilustrasikan atau mendeskripsikan serta mempunyai tujuan mentranliterasi bahasa ke-Tuhanan kepada seorang hamba (`abdu) untuk selalu mensyukuri konsep syukur baik dalam ungkapan/ucapan maupun perintah bersyukur Iman diperoleh setelah seorang merenungi dan mentadabburi seluruh ciptaan Allah dan berimplikasi dengan rasa syukur dan pengamalannya pada kehidupan sehari-hari.
EFFICIENCY OF MONITORING AND HEALTH OF CHILD POPULATION IN THE EDUCATIONAL ENVIRONMENT
Authors: Yamanova G. A , Serdyukov V. G , Antonova A. A , Milyuchenkova L. A , Shirinova Z. R
Published: December 2021

The article is devoted to the problems of the health status of students in educational institutions and the early detection of functional deviations among them. The aim of the study was to assess the effectiveness of the introduction of screening techniques for prenosological diagnostics in modern conditions of the educational environment. Comprehensive monitoring of the health status of children of secondary school age was carried out for 4 years with the aim of prenosological diagnosis and subsequent correction of functional deviations. The results allow us to conclude about the effectiveness and availability of monitoring in the conditions of educational organizations.
ANALYSIS OF THE ACCOMMODATION STATE BEFORE AND AFTER FemtoLASIK IN PATIENTS WITH HYPEROPIA
Authors: Kuznetsova O. S , Balalin S. V.
Published: December 2021

The results prospective study of accommodation in 114 patients with hyperopia (114 eyes) before and after FemtoLASIK were analyzed. According to the data of a prospective study after FemtoLASIK, the 114 patients were diagnosed with false myopization syndrome in 42,1 % of cases, which was caused by accommodation disorders pre-op. The following data were revealed pre-op: habitually excessive accommodation stress (HEAS) - 22,8 %, weakness of accommodation - 38,6 %, HEAS in combination with weakness of accommodation - 24,6 %. A significant improvement in accommodation was noted after FemtoLASIK: HEAS was detected only in 4.8% of cases and HEAS in combination with weak accommodation in 9,5% of cases, a decrease in the severity of asthenopia.
СHARACTERISTICS OF THE EXPRESSION OF ENDOTHELIAL NO-SYNTHASE IN THE DENTATE GYRUS OF RATS WHEN MODELING A DEPRESSIVE STATE AND THE POSSIBILITY OF PHARMACOLOGICAL CORRECTION WITH PHENIBUT
Authors: Smirnov A. V , Ekova M. R , Tyurenkov I. N , Volotova E. V
Published: December 2021

Depression is one of the leading causes of declining working capacity in the population and remains one of the most common mental disorders in the world in all age groups. The features of the expression of endothelial NO-synthase in the dentate gyrus in mature rats were assessed when simulating a depressive state, as well as the possibility of pharmacological correction of the revealed changes with phenibut. Evaluation of changes in the level of expression of immunoreactive material in the dentate gyrus was determined in the granular and subgranular layers by assessing the intensity of staining in points from 0 to 3. In rats with an experimental depression, compared with the control group, there was a decrease in the degree of expression of immunoreactive material in the dentate gyrus. The use of phenibut contributed to the correction of the studied signs.
SYNDROME OF «LARGE EOSINOPHILIA» WITH LESIONS OF THE GALLBLADDER IN SUPERINVASIVE OPISTHORCHIASIS
Authors: Uruzbaev R. M. , Zolotukhin V. M. , Khadieva E. D. , Lazarev S. D , Bychkov V. G
Published: December 2021

In the hyperendemic hotbed (Ob-Irtysh river basin), human opisthorchiasis is represented mainly by the superinvasive form, in which there is a syndrome of "large eosinophilia" with damage to many organs and systems. The analysis of 43 observations of hypereosinophilic syndrome with the development of eosinophilic cell granulomatous lesions of the gallbladder wall was carried out. The article presents the observation of eosinophilic cell granulomatous cholecystitis against the background of superinvasive opisthorchiasis. The pathomorphological picture of the liver (marginal biopsy) in the syndrome of "large eosinophilia" is presented.
ASSESSMENT OF HEPATOTOXICITY OF MULTIPLE ANTIVIRAL RIAMILOVIR PREPARATION ADMINISTRATION IN NON-LINEAR GUINEA PIGS MODEL
Authors: Fedulova K. D , Izmozherova H. V , Petrov A. Yu , Gavrilov I. V , Slovesnova N. V
Published: December 2021

The aim of this study was to asses hepatoxicity of riamilovir with repeated administration on the animal model. Materials and methods. Twenty non-linear guinea pigs were randomized into 4 groups: control and three experimental, receiving 64 days of daily riamilovir orally in doses of 48, 96, 144 mg/kg. Biochemical profile: ALT, AST, GGT, total protein, total and direct bilirubins, albumin, cholesterol, triglycerides: on 0, 33 and 65 days from the start of the experiment. Results. A significant decrease of serum albumin and cholesterol levels was found only in group 2 and there were no statistically significant changes of other indicators. Conclusion. The data obtained indicate afunctional liver synthetic function changes without signs of hepatobiliary and hepatocellular damage.
CRITERIA FOR THE SELECTION OF PATIENTS WITH AN ACUTE HEART FAILURE EVENT FOR THE CORRECTION OF STRESS RESISTANCE AND SOCIAL ADAPTATION IN COMPLEX REHABILITATION DURING A PANDEMIC COVID-19
Authors: Arutyunov A. K , Martynenk A. V
Published: December 2021

The article presents the results of a survey according to the "Methodology for determining stress resistance and social adaptation of Holmes and Rage" 28 men and 33 women who underwent inpatient treatment in the cardiology department of (SBIHC RA) Adygea republican clinical hospital with myocardial infarction (MI) and hypertension complicated by the crisis (HCC). Men showed the dynamics of the growth of HCC was revealed after 61 years, while in the subgroup up to 61 years, MI prevailed. Women subgroups' results were opposite. Significant stress load was found both in male subgroups, especially under 61 years, and in female subgroups. The criteria for the selection of patients into high and moderate risk groups for subsequent psychological correction are identified. Recommendations are given on the inclusion of psychological correction in the general rehabilitation program for patients with an acute cardiac event during the period of hospital treatment and dispensary observation at the outpatient-polyclinic level.
NEURO-PSYCHIC STATE OF WEATHER SENSITIVE PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Kildebekova R. N , Vardikyan A. G , Bikkinina G. M , Kaybishev V. T , Fedotov A. L , Sayachov R. F
Published: December 2021

The work studied neuro-psychic state of weather sensitive patients of working age suffering from arterial hypertension. The study shows the effectiveness of Aphobazolum in a complex treatment. The studied weather sensitive people have more pronounced symptoms of anxiety, subdepression and decreased cognitive functions. After the treatment of weather sensitive patients with arterial hypertension with additional administration of Aphobazolum we noticed significant reduction of anxiety level and subdepression, increased cognitive functions and achievement of aim level of arterial blood pressure in more patients.
EFFECT OF CHRONIC STRESS ON PRIMARY AND SECONDARY LYMPHOID O RGANS OF RATS AND ITS REVERSIBILITY DEPENDING ON THE DURATION OF STRESS EXPOSURE
Authors: Muraeva N. A. , Smirnova T. S , Fedorova O. V. , Tkachenko Yu. A , Vondrachek L. V
Published: December 2021

The influence of chronic stress on the lymphoid organs and its reversibility depending on the duration of exposure was studied. Male rats were subjected to stress - restricted movement and forced swimming daily for 2, 4 and 8 weeks. After each exposure period, the rats were allowed to recover for 6 weeks. Stress exposure led to a decrease in the mass of the thymus and axillary lymph nodes, the number of spleen lymphocytes, thymus and axillary lymph nodes, and an increase in the apoptotic index of splenocytes, thymocytes and lymphocytes of axillary lymph nodes, depending on its duration. The thymus was the most stress-sensitive lymphoid organ. After 2 and 4 weeks of stress exposure, the spleen parameters and most of the parameters of the thymus and axillary lymph nodes in rats returned to the control level after recovery, but not in the group with 8 weeks of stress exposure. The severity of stress on the lymphoid organs increases with the duration of exposure, and with a shorter period of exposure, recovery occurs faster.
EVALUATION OF PARAMETERS FOR THE HEART RATE VARIABILITY AND POSTURAL DISORDERS IN PATIENTS WITH DISTAL AND PHYSIOLOGICAL OCCLUSION
Authors: Zangieva A. S , Sorokina N. D , Pertsov S. S , Gioeva Yu. A , Demyanenko M. V. , Selitsky G. V.
Published: December 2021

Our study revealed the correlations between parameters that reflect changes in the systemic regulation of physiological functions during abnormal occlusion accompanied by disturbances in postural control. Estimating the heart rate variability, studying the posture (by means of computer optical topography), and performing the tests for activity of the autonomic nervous system showed that a normal functional state is characterized by coordinated activity of the postural control apparatus, occlusion of dentition, and other physiological systems. By contrast, the predominance of sympathetic autonomic regulation and anomaly of occlusion in the form of distal occlusion are is accompanied by the certain postural disorders (scoliosis of the 1st - 2nd degree in the frontal plane). Orthodontic treatment was followed by a decrease in activity of the sympathetic nervous system for heart rate regulation, which illustrates an increase in the adaptability of cardiovascular functions. These data are promising for an improvement of instrumental procedures for functional diagnostics in physiology and dentistry.
COMPARISON OF THE NEURO PSYCHOTROPIC PROPERTIES OF THE (R)-ISOMER AND THE RACEMIC FORM OF THE TOLIBUT
Authors: Kovalev N. S , Bakulin D. A , Kurkin D. V. , Pustynnikov V. E , Reznikov A. N , Klimochkin Yu. N
Published: December 2021

The use of biologically active enantiomers instead of racemic forms is currently a promising approach to improving the properties of known drugs. In such derivatives of GABA as phenibut and baclofen, the pharmacological activity is determined by the (R)-isomer. The potential for the possible clinical use of tolibut is limited by a narrow spectrum of therapeutic action. One of the ways to expand it may be the approach of isolating and studying the active enantiomer. The sedative, anxiolytic, nootropic, antihypoxic effects, as well as the toxicity of the (R)-isomer and racemate of tolibut were evaluated. The performed study showed that the (R)-isomer of tolibut has a more pronounced muscle relaxant, antihypoxic effect, exhibits less pronounced anxiolytic activity and less toxicity compared to racemate.
INFLUENCE OF ADAMANTANE 2-PYRROLIDONE DERIVATIVE ON PHYSICAL PERFORMANCE, PSYCHOEMOTIONAL AND COGNITIVE FUNCTIONS OF LABORATORY ANIMALS IN COMPARISON WITH BROMANTHANE
Authors: Kovalev N. S , Bakulin D. A , Abrosimova E. E , Kurkin D. V , Pustynnikov V. E , Klimochkin Yu. N , Tkachenko I. M , Tyurenkov I. N
Published: December 2021

The effect of a new adamantane derivative of 2-pyrrolidone on the physical performance of rats when swimming with a load (for 5 days) was studied. It has been shown that a course, 5-day administration of IE-1 at a dose of 23 mg/kg 60 min before the first swim, significantly increases the swimming duration, comparable to that of bromantane. In addition, after a 5-day swim, animals treated with IE-1 showed higher motor and exploratory activity in the Open Field test, a lower level of anxiety in the Light/Dark Box test, and better indicators of cognitive function in the novel object recognition test.
RESULTS OF SURGICAL TREATMENT OF EXTENSIVE HEMORRHAGIC RETINAL DETACHMENTS BY MEANS OFWIDE RETINOTOMY IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Authors: Arkhipov E. V , Yakimov A. P , Kuzmin S. V , Zaika V. A , Ryazantsev N. S
Published: December 2021

The article presents an analysis of the surgical treatment efficacy of hemorrhagic retinal detachment in 2 patients (2 eyes) with neovascular age-related macular degeneration (AMD) using a wide retinotomy to remove subretinal hemorrhage. The results were evaluated 3 months after the operation. In both cases, a complete retinal fitting was achieved, the early and long-term postoperative periodswere without complications, no recurrence of detachment was observed.
Analisis Pemahaman Pemenuhan Kebutuhan Dasar Anak Usia Dini selama Masa Pandemi COVID-19 berdasarkan Karakteristik Ibu
Authors: Putri Amelia , Widyani Karina Novia , Mazida Zulfa , Husna Ahsanu Bil , Sari Yunita Permata , Putri Mauril Yunita , Wahyuni Yulia Tri
Published: December 2021

Usia dini merupakan masa emas tumbuh kembang optimal anak. Pemenuhan kebutuhan dasar anak sangat diperlukan anak-anak untuk dapat bertumbuh dan berkembang dengan optimal. Pada kondisi pandemi, tidak semua anak berada pada kondisi yang baik untuk mendapatkan kebutuhan dasarnya dari orangtua. Penelitian ini bertujuan untuk menganalisis karakteristik ibu dalam pemahaman terkait pemenuhan kebutuhan dasar anak usia dini yang terdiri dari usia, pendidikan, pendapatan dan pekerjaan ibu. Penelitian ini menggunaan desain analitik cross sectional. Populasi dalam penelitian ini adalah orangtua anak usia dini (3-6) tahun khususnya ibu dari murid TK Al Amien Jember. Penentuan sampel dilakukan dengan simple random sampling dan diperoleh sampel sebesar 75 ibu. Analisis data dilakukan menggunakan SPSS versi 21 melalui uji chi-square dan spearman test. Hasil penelitian menunjukkan bahwa ibu yang memiliki pemahaman tinggi tentang pemenuhan kebutuhan dasar anak adalah ibu yang berusia antara 31 – 35 tahun, pendidikan terakhir D4/S1, bekerja penuh waktu dan memiliki pendapatan keluarga sebesar 4 – 5 juta per bulan. Berdasarkan analisis korelasi didapatkan bahwa tidak ada hubungan antara karakteristik ibu dengan pemahaman ibu tentang pemenuhan kebutuhan dasar anak selama masa pandemik. Hal ini membuktikan bahwa di masa pandemi ini, sebagian besar ibu memiliki tanggungjawab besar dalam pemenuhan kebutuhan dasar anak tanpa terpengaruh oleh berbagai karakteristiknya. Bagaimanapun status pekerjaannya, peran ibu dalam pemenuhan kebutuhan dasar anak tidak bisa digantikan dan tidak menjadikan seorang ibu pekerja tidak memenuhi kebutuhan dasar anak yang terdiri dari asah, asih dan asuh.
Profil Kemampuan Spasial dalam Menyelesaikan Soal Materi Balok dan Kubus Berdasarkan Jenis Kelamin Siswa Kelas VIII SMPN 1 Genteng
Authors: Lestari Silvia Vera , Sunardi Sunardi , Sugiarti Titik , Silaturohman Silaturohman
Published: December 2021

Mathematics is one part of the science in education that we learn. In studying mathematics, especially geometry, spatial abilities play an important role in it. The purpose of this study was to describe the spatial ability profile of class VIII SMPN 1 Genteng  in solving cuboid and cube theory problems for male and female students. Indicators of spatial ability are developed based on elements of spatial ability, namely spatial perception, mental rotation, and spatial visualization. The results of this study are male students with high spatial ability can master all elements of spatial ability, male students with moderate spatial ability are able to fulfill several elements of spatial ability. Female students with high spatial ability can fulfill all elements of spatial ability, female students with moderate spatial ability are able to fulfill several elements of spatial ability, female students with low spatial ability have difficulty fulfilling elements of spatial ability.
Efektivitas Penerapan E-Modul dalam Meningkatkan Pemahaman Siswa Kelas VIII pada Materi Pola Bilangan Masa Pandemi
Authors: Puspitasari Sayekti Nur , Suyono Suyono , Astutiningtyas Erika Laras
Published: December 2021

Pelaksanaan pembelajaran online menjadi tantangan bagi para guru matematika dalam memberikan materi pola bilangan kepada siswa. E-Modul merupakan salah satu media yang dapat digunakan untuk mendukung pembelajaran secara online. Penelitian ini bertujuan untuk mengetahui langkah-langkah pembuatan E-Modul dan efektivitas penerapan E-Modul dalam meningkatkan pemahaman siswa. Penelitian ini merupakan penelitian kualitatif. Teknik pengumpulan data yang digunakan yaitu metode angket dan wawancara. subjek penelitian siswa kelas VIII SMP N 2 Tawangsari. Hasil dari penelitian menunjukan bahwa persentase rata–rata tiap aspek respon siswa terhadap penerapan E-Modul dalam meningkatkan pemahaman siswa kelas VIII pada materi pola bilangan termasuk dalam kategori baik, yang artinya para siswa setuju dengan adanya penerapan E-Modul dalam meningkatkan pemahaman pada materi pola bilangan.
A corpus study of English “nautical” idioms
Authors: Shchagina Olga V.
Published: December 2021

We attempt to study nautical history influence on the phraseology of contemporary English. Britain’s geographical location and consequently its dependence on the surrounding seas greatly affected the language of all English-speaking countries. On the basis of criteria defined by J. Swales and ideas of W. Teubert, we identify the English-speaking discourse community of sea-farers. The assessment of historical and social conditions made it possible to determine the causes and the impact of the highly specialized language of this discourse community on the entire Eng-lish language. Following the study of two main approaches when working with language corpora (corpus-based and corpus-driven), we conducts corpus-driven research relying totally on the data obtained from the corpus. Using the material from the English language corpus NOW (News on the Web), we study the context and extent of distribution of seven phraseological units with com-ponents with the semantics of navigation in two main variants of the English language: British and American. The data obtained showed partial grammatical and syntactic discrepancies, as well as acceptable variations in the lexical structure of some units. The study of original nautical meanings allows us to understand the metaphorical mapping underlying the sense of the idioms.
Once again about the prophetic mission of the Russian writer (based on material of Y.V. Bondarev’s novel “The Shore”)
Authors: Khvorova Liudmila E.
Published: December 2021

We conduct continuous poetical and philosophical research on the work of Y.V. Bondarev (1924–2020), the greatest Russian Soviet prose writer and a participant in the Great Patriotic War. Based on the study of the novel “The Shore” (1975) and the writer’s journalistic statements of the mid-1970s of the 20th century, within the framework of cultural-axiological paradigm, we attempt to comprehend one of the central dialogues between representatives of the creative intellectuals of Russia and West. The conversation between Russian Soviet writer Nikitin, a former front-line soldier who visited the German city of Hamburg 26 years after the war, and the German journalist and publisher Dietzman is read as a kind of philosophical quintessence of both this novel and, possibly, the writer’s work as a whole. The conflict between Russia and West is seen by Y.V. Bondarev in the most complex metaphysical paradigm of the struggle of largely opposite cultural foundations, despite the common Christian basis. We state the complexity, multidimensionality, polyphonism of the Bondarev type of artistic expression, its ascent to the traditions of Russian literary classics and, above all, in this case to the work of F.M. Dostoevsky. We note the key, culminating significance of this dialogue-reflection undertaken in the chapter of the second chapter of the third part “Nostalgia” by Dietzman and Nikitin, which has some obvious similarities with the author both for the further development of latter’s character in the poetical and philosophical space of novel, and for its artistic “completion” in work finale. We comprehend the relevance of Bondarev’s metaphysical constants in the first quarter of the 21st century, prophetically written out about half a century ago.
Evaluasi Koleksi Perpustakaan Fakultas Ilmu Budaya Universitas Lancang Kuning berdasarkan RPS
Authors: Safitri Melgia , Sudiar Nining , Hakim Triono Dul
Published: December 2021

Penelitian ini bertujuan untuk mengetahui tingkat ketersediaan koleksi Perpustakaan Fakultas Ilmu Budaya Universitas Lancang Kuning Berdasarkan RPS. Metode penelitian ini adalah deskriptif kuantitatif. Sampel pada penelitian ini adalah seluruh RPS yang tersedia pada kurikulum. Hasil penelitian ini menunjukkan bahwa Ketersediaan koleksi Perpustakaan Fakultas Ilmu Budaya berdasarkan RPS untuk mata kuliah wajib jurusan Sastra Melayu yaitu tersedia 56 judul dengan persentase 21% atau hampir setengahnya dan koleksi yang tidak tersedia sebanyak 206 judul dengan persentase 79% atau lebih dari setengahnya. Kemudian jurusan Sastra Indonesia tersedia sebanyak 22 judul dengan persentase 19% atau sebagian kecil dan koleksi yang tidak tersedia sebanyak 93 judul dengan persentase 81% atau sebagian besar. Kemudian jurusan Sastra Inggris koleksi yang tersedia yaitu 22 judul dengan persentase 8% atau sebagian kecil dan koleksi yang tidak tersedia sebanyak 258 judul dengan persentase 92% atau sebagian besar. Selanjutnya jurusan Ilmu Perpustakaan koleksi yang tersedia sebanyak 46 judul dengan persentase 32% atau hampir setengahnya dan koleksi yang tidak tersedia sebanyak 99 judul dengan persentase 68% atau lebih dari setengahnya. Sedangkan ketersediaan koleksi Perpustakaan Fakultas Ilmu Budaya berdasarkan RPS untuk mata kuliah pilihan jurusan Sastra Melayu yaitu tersedia sebanyak 7 judul dengan persentase 19% atau sebagian kecil dan koleksi yang tidak tersedia sebanyak 30 judul dengan persentase 81% atau sebagian besar. Kemudian jurusan Sastra Indonesia koleksi yang tersedia yaitu 1 judul dengan persentase 33% atau hampir setengah dan koleksi yang tidak tersedia yaitu 2 judul dengan persentase 67% atau lebih dari setengahnya.  Kemudian Jurusan Sastra Inggris tersedia 1 judul dengan persentase 10% atau sebagian kecil dan koleksi yang tidak tersedia yaitu 9 judul dengan persentase 90% atau sebagian besar. Selanjutnya jurusan Ilmu Perpustakaan yaitu tersedia 4 judul dengan persentase 80% atau lebih dari setengahnya dan koleksi yang tidak tersedia sebanyak 1 judul dengan persentase 20% atau sebagian kecil.
Analisis Perilaku Informasi Mahasiswa Universitas Lampung: Suatu Kajian pada Proses Penelusuran Koleksi Karya Ilmiah dan Koleksi Sirkulasi
Authors: Erni Fitriani Sugiyanta -
Published: December 2021

Information and communication technology in its development has an effect on human life covering social, economic, cultural aspects, including libraries.Libraries are required to provide up to date information and in diverse forms. There are differences in information behavior of University Students of Lampung on searching collections of scientific paper and circulation collections. The aims of this research are  to find out the information behavior of students of Lampung University in the process of tracing collections of scientific works and circulation collections, and mention the similarities and regulations of information behavior in the search of collections of scientific works and searches of circulation collections. This research methode uses qualitative descriptive with data collection techniques through observation, documentation data and literature study. The results obtained  are :  information behavior University Student of Lampung on searching collections of scientific papers are: most students of Lampung University on searching collection of scientific papers using a laptop to access on the link: digilib.unila.ac.id., log in, search the faculty, study programs, published years and titles of scientific paper, do the citation, and save cited to file work. Information behavior University Students of Lampung on searching   circulation collections are: most University Student of Lampung on searching circulation collections using the computer library provided, access on the link: opac.unila.ac.id (online catalog), write down the name of the author or the title of book, record the call number of the circulation collections of interest, to the circulation collection shelves, take circulation collections to read or borrow to take home. But there are also similarities in the behavior of information in the process of disseminating the collection of scientific works and tracing the circulation collection, namely both the search process is done online and search for information by writing the title of the work both books and scientific works.Keywords: information behavior, University Student of Lampung, scientific paper                   collections, circulation collections, University Library of Lampung
DAĞLIK KARABAĞ MESELESİNDE DEĞİŞEN GİDİŞAT VE TÜRKİYE'NİN ROLÜ
Authors: ÖZDEMİR Levent
Published: December 2021

19. yüzyılda Çarlık Rusya tarafından işgal edilen Azerbaycan toprakları, Karabağ Hanlığı’nın Rus egemenliğine girmesiyle demografik olarak sistematik bir dönüşüm yaşamıştır. 1826’da İran’ı mağlup eden Rusya, 1828 Türkmençay Anlaşması ile Azerbaycan topraklarının kuzeyini alırken, güneyini İran’a bırakmıştır. Dağlık Karabağ bölgesi için kırılma noktası olan bu anlaşmayla Ruslar, Dağlık Karabağ’a Ermenileri göç ettirerek, yapay bir bölge inşa etmiştir. Zamanla çoğunluk haline gelen Ermeniler, Karabağ bölgesinden hak iddia eder duruma gelmiştir. Gerek Sovyetler döneminde gerekse Sovyetlerin çöküşü ile Karabağ bölgesindeki taleplerinden vazgeçmeyen Ermeniler, 1992-1994 yıllarında Dağlık Karabağ’ı ve civarındaki illeri işgal ederek, birçok masum Azerbaycanlıyı katletmiştir. Bu süreçte uluslararası kuruluşlar soruna çözüm bulamamış, Azerbaycan toprakları yaklaşık otuz yıl boyunca Ermenistan işgali altında kalmıştır. Temmuz 2020’de Ermenistan’ın Azerbaycan’a karşı saldırıya geçmesiyle çatışmalar tekrar başlamıştır. Ancak bu kez gidişat Ermenistan’ın aleyhine dönmüştür. Türkiye’nin bölgede izlediği etkili politikalar ve Azerbaycan’a verdiği askeri ve siyasi destek, Azerbaycan’ın askeri üstünlüğü ile birleşince akabinde Karabağ zaferini getirmiştir.
BAĞIMSIZ DENETİMİN KALİTESİNDE KANITLARIN ROLÜ
Authors: İKVAN Abdulrezzak , DEMİRKOL Ömer Faruk
Published: December 2021

İşletme finansal bilgilerin doğruluğu veya gerçekliği bağımsız denetçilerin yeterli ve uygun kanıtlarla ilgili iddiaları denetlemesiyle mümkündür. Bu durum, kanıtları denetim kalitesinde önemli bir unsur haline getirmektedir. Kanıtların yeterliliği ve uygunluğu, denetim kalitesinin düzeyiyle doğru orantılıdır. Başka bir açıdan değerlendirildiğinde kanıtlar bir yandan yönetim iddialarının doğruluğunu ve gerçekliğini ispatlamaya yönelik delil niteliği taşırken diğer yandan yargısal süreçlerde denetçilere savunma unsuru olabilmektedir. Bu durum denetim kanıtların, taraflarda güven unsuru olarak görülmekte ve denetim faaliyetine güven ve kalite sağlamaktadır.

Çalışmada bağımsız denetimin kalitesinde denetim kanıtlarının rolü ve önemi teorik olarak incelenmiş ve kanıtlara genel bir çerçeve çizilmiştir. Aynı zamanda çalışmada denetim kalitesinin sağlanması için kanıtların özellikleri belirlenmeye çalışılmıştır. İlgili konular içerik değerlendirilmesi şeklinde araştırılmış ve yapılan değerlendirilmeler sonucunda denetim kalitesinin sağlanmasında kanıtların yeterlilik ve uygunluk özellikleri literatür çalışmalarında da belirtildiği gibi önemli olduğu şeklinde değerlendirilmiştir. Bununla birlikte yapılan değerlendirmelerde kanıtların bağımsız ve tarafsız bakış açısıyla elde edilmesi; fiziki, onaylı, dış kaynak ve teknolojiye dayalı kanıtların sağlanması denetim kalitesine etki ettiği beirlenmiştir.
JOHN LOCKE’UN SİYASET FELSEFESİ
Authors: AKKURT Mehmet
Published: December 2021

İnsan hakları, demokrasi, özgürlük, eşitlik, mülkiyet, yönetim ve siyasi iktidar gibi problemler bugün hala siyaset felsefesinde tartışma konusu olan problemlerdir. On yedinci yüzyılda yaşamış olmasına rağmen Locke’un bugün hala önem arz etmesinin nedeni, söz konusu olan bu problemlerin onun düşüncesinde yer bulmasıdır. Locke’a göre insana dair problemleri anlamak ve çözmek, insan doğasını anlamayı gerektirir. İnsan doğası doğru bir şekilde anlaşılmazsa veya görmezden gelinirse, mevcut problemleri çözmek ve mevcut durumu iyileştirmek mümkün değildir. Doğa yasasının temeli olan şey, insanın kendini koruma arzusudur ve bu arzu insan doğasındaki en kuvvetli tek güçtür. İnsan doğasındaki bu en kuvvetli güç, hem doğa durumunda hem de sivil durumda insanların davranışlarını belirleyen şeydir. İnsanların doğa durumun eksikliklerini ve bu bağlamda ortaya çıkan kötülükleri engellemek için sivil duruma geçmeleri; yasa yapacak ve ihtilafları hükme bağlayacak bir iktidar, kararları uygulayacak ve suçluları cezalandıracak bir iktidar sağlayarak mülkiyeti (yaşam, özgürlük ve servet) güvence altına almaya çalışmaları, kendilerini koruma arzularından kaynaklanır. İnsanlar bu gücü anlayamazlarsa ve görmezden gelirlerse, kendi durumlarını ve şartlarını iyileştirmek için yapmış oldukları bütün çabalar, kendi şartlarını iyileştirmek yerine daha da kötüleştirecektir. Bundan dolayı Locke’a göre, insan doğasına aykırı hiçbir düzenleme varlığını devam ettiremez. Bu makalenin amacı, Locke’un siyaset felsefesinin temellerini ve bu bağlamda onun demokrasi, özgürlük, eşitlik, mülkiyet, yönetim ve siyasi iktidara ilişkin görüşlerini; siyasi iktidarın hakiki kaynağını, amacını ve meşruiyetini ortaya koymaktır. Bunlar, bugün hala önemli problemlerdir ve Locke’un görüşleri bize hala rehberlik edebilecek niteliktedir. Bundan dolayı asıl meselesi özgürlük ve insanı özgür kılmak olan Locke’un siyasi öğretisi bu çalışmada net bir şekilde ortaya konmaya çalışıldı.
IDENTIFYING DEVELOPMENT PRIORITIES OF UNDERGROUND INFRASTRUCTURE IN METROPOLISES USING SYSTEM METHODOLOGY
Authors: Haiko Hennadiy , Savchenko Іllia , Pankratova Nataliya
Published: December 2021

Purpose: Determining construction priorities of underground transport infrastructure objects by evaluating morphological models of car tunnels considering the impact on the ecological and technogenic safety of urbanized territories.

Methodology: modified morphological analysis of geological environment, urbanized territories and transport infrastructure of sites in a metropolis, expert estimation method.

Findings: a morphological model was tested as a tool set for determining construction priorities of underground transport infrastructure objects; inter-related morphological tables for geological environment and structural-functional factors of urbanized territories in a tunnel area were constructed; an estimation of models regarding development of underground infrastructure was conducted using the planned car tunnels in Kyiv as an example; the impact of tunnels on reducing the ecological and technogenic risks of urbanized space was justified, and the priority construction object was chosen according to these criteria.

Originality: for the first time the reduction of ecological and technogenic risks of urbanized space was chosen as a goal function in morphological models for the development of underground transport infrastructure in metropolises; the systemic characteristics of urban territories were obtained that describe the favorability of the geological environment and structural-functional factors for car tunnel construction in center metropolis areas; an impact ratio was proposed for synthesizing morphological analysis results and determining the priorities of underground transport infrastructure objects by influence on the ecological and technogenic risks.

Practical implications: the created methodology and tool set for determining priorities of underground object construction at the pre-project stage, the opportunity to consider the ecological and technogenic risks of urban space development by consecutive construction of underground transport infrastructure objects and identifying an order for this sequence.
Chromatic Number and Neutrosophic Chromatic Number
Authors: Garrett Henry
Published: December 2021

New setting is introduced to study chromatic number. Neutrosophic chromatic number and chromatic number are proposed in this way, some results are obtained. Classes of neutrosophic graphs are used to obtains these numbers and the representatives of the colors. Using colors to assigns to the vertices of neutrosophic graphs is applied. Some questions and problems are posed concerning ways to do further studies on this topic. Using strong edge to define the relation amid vertices which implies having different colors amid them and as consequences, choosing one vertex as a representative of each color to use them in a set of representatives and finally, using neutrosophic cardinality of this set to compute neutrosophic chromatic number. This specific relation amid edges is necessary to compute both chromatic number concerning the number of representative in the set of representatives and neutrosophic chromatic number concerning neutrosophic cardinality of set of representatives. If two vertices have no strong edge, then they can be assigned to same color even they’ve common edge. Basic familiarities with neutrosophic graph theory and graph theory are proposed for this article.
Antidepressant Sertraline is a Broad-Spectrum Inhibitor of Enteroviruses Targeting Viral Entry Through Neutralization of Endolysosomal Acidification
Authors: Tseng Kuan-Chi , Hsu Bang-Yan , Ling Pin , Lu Wen-Wen , Lin Cheng-Wen , Kung Szu-Hao
Published: December 2021

Enterovirus 71 (EV71) is an etiological agent of hand foot and mouth disease and can also cause neurological complications in young children. However, there are no approved drugs to treat EV71 infections. In this study, we conducted an antiviral drug screening by using a Food and Drug Administration (FDA)-approved drug library. We identified five drugs that showed dose-dependent inhibition of viral replication. Sertraline was further characterized because it exhibited the most potent antiviral activity with the highest selectivity index among the five hits. The antiviral activity of sertraline was noted for other EV serotypes. The drug’s antiviral effect is not likely associated with its approved indications as an antidepressant and its mode-of-action as a selective serotonin reuptake inhibitor. The time-of-addition assay revealed that sertraline inhibited an EV71 infection at the entry stage. We also showed that sertraline partitioned into acidic compartments, such as endolysosomes, to neutralize the low pH levels. In agreement with the findings, the antiviral effect of sertraline could be relieved greatly by exposing virus-infected cells to extracellular low-pH culture media. Together, we have identified an FDA-approved antidepressant with the new indication for the broad-spectrum EV inhibition by blocking viral entry through the alkalization of the endolysosomal route.
Protein and mRNA Quantification in Small Samples of Human Induced Pluripotent Stem-cell-derived Cardiomyocytes in 96-well Microplates
Authors: Li Weizhen , Han Julie , Entcheva Emilia
Published: December 2021

We describe a method for protein quantification and for mRNA quantification in small sample quantities of human induced pluripotent stem-cell-derived-cardiomyocytes (hiPSC-CMs). Demonstrated here is how the capillary-based protein detection system WesTM by ProteinSimple and the Power SYBRTM Green Cells-to-CTTM Kit by Invitrogen can be applied to individual samples in a 96-well microplate format and thus made compatible with high-throughput (HT) cardiomyocyte assays. As an example of the usage, we illustrate that Cx43 protein and GJA1 mRNA levels in hiPSC-CMs are enhanced when the optogenetic actuator, channelrodopsin-2 (ChR2), is genetically expressed in them. Instructions are presented for cell culture and lysate preparations from hiPSC-CMs, along with optimized parameter settings and experimental protocol steps. Strategies to optimize primary antibody concentrations as well as ways for signal normalization are discussed, i.e. antibody multiplexing and total protein assay. The sensitivity of both the Wes and Cells-to-CT kit enables protein and mRNA quantification in a HT format, which is important when dealing with precious small samples. In addition to being able to handle small cardiomyocyte samples, these streamlined and semi-automated processes enable quick mechanistic analysis.
Acetyltransferases GCN5 and PCAF are Required for B Cell Maturation in Mice
Authors: Oksenych Valentyn
Published: December 2021

B lymphocyte development includes two DNA recombination processes, the V(D)J recombination of immunoglobulin (Igh) gene variable region and class switching when the Igh constant regions are changed from IgM to IgG, IgA, or IgE. The V(D)J recombination is required for successful maturation of B cells from pro-B to pre-B to immature-B and then to mature B cells in the bone marrow. The CSR occurs outside the bone marrow when mature B cells migrate to peripheral lymphoid organs, such as spleen and lymph nodes. Both V(D)J recombination and CSR depend on an “open chromatin” state that makes DNA accessible to specific enzymes, recombination activating gene (RAG), and activation-induced cytidine deaminase (AID). Acetyltransferases GCN5 and PCAF possess redundant functions acetylating histone H3 lysine 9 (H3K9). Here, we generated by complex breeding a mouse model with B cells lacking both GCN5 and PCAF. We found that double-deficient mice possess low levels of mature B cells in the bone marrow and peripheral organs, accumulation of pro-B cells in bone marrow, and reduced CSR levels. We concluded that both GCN5 and PCAF are required for B cell development in vivo.