bluuebunny/crossref_metadata_2025 huggingface dataset:
ECOCIDE
Authors: Kowalska Samanta
Published: June 2023

Over time, ecocide was considered mainly through the praxiology of command. This paper will demonstrate that actions aiming to prevent ecocide are hindered by the existing reference point in the construction of environmental standards. In order to build ecological safety, the illusory and short-term nature of environmental projects should be neutralised. Ecocide is a threat that requires solutions both at the level of national law and a forward-oriented global strategy. The discussion will show that ecocide is a virulent and pejorative phenomenon that currently goes beyond classically understood ecocrime. Preventing ecocide is an urgent necessity of a civilisational nature. The intergeneration component will be highlighted in considerations, which should encourage the updating and implementation of a strategy with a view to ensuring ecological safety on a continuous basis. The formal-dogmatic and comparative method in interpretation legal acts of international law with legal documents in the field of environmental protection has been applied in order to justify the hypothesis. Scientific research are accompanied by an analyze the relationship between the nature and human world.
POTENCIALIDADES DO PROJETO DE SOCIEDADE DOS DIREITOS HUMANOS E DA NATUREZA
Authors: Pinto João Batista Moreira , González Botija Fernando , Rios Mariza
Published: June 2023

Este trabalho busca evidenciar duas construções teórico-políticas e culturais, os direitos humanos e os direitos da natureza, diante dos desafios e contradições da modernidade alicerçada no antropocentrismo e em uma racionalidade econômica instrumental. Considerando-os projetos de sociedade, buscou-se resgatar seus elementos caracterizadores, suas tensões e seu potencial emancipatório ante as contradições sociais, culturais e socioambientais decorrentes do modelo hegemônico de desenvolvimento. A hipótese dos autores é que esses dois projetos possam ser trabalhados de maneira integrada, buscando agregar e articular suas potencialidades emancipatórias, em vista de uma sociedade pautada na inter-relação entre os direitos humanos e os direitos da natureza. A metodologia utilizada foi a pesquisa bibliográfica, vinculada à observação empírica do processo dialético da práxis social em torno dos direitos humanos e dos direitos da natureza. Diante das análises e reflexões desenvolvidas, concluiu-se pela confirmação da hipótese, com a afirmação do projeto dos direitos humanos e da natureza, com sua potencialidade norteadora diante dos desafios contemporâneos de efetivação dos direitos humanos e da natureza.
RESPONSABILIDADE SOCIAL CORPORATIVA
Authors: Gonçalves Ribeiro Luiz Gustavo , Leite Sampaio José Adércio
Published: June 2023

Como expressão rica de sentidos e usos, o trabalho revela os sentidos da Responsabilidade Social Corporativa. O texto apresenta, sob a égide da revisão bibliográfica e do método lógico-indutivo, a sequência histórica do sentido do termo e culmina pela exposição de modelo conceitual de gestão que agrega aspectos econômicos e sociais, com respeito aos direitos humanos, e que possui o ambiente como imperativo de responsabilidade. Expõe-se a eventual emergência no passo de um documento internacional vinculante, de modo a evitar um gravitante rótulo reputacional que pode ser cunhado como blue, green ou outros washings. Apresenta-se, pois, como primeiro resultado da pesquisa, que as empresas, hoje, não cumprem sua função social apenas com geração de lucros, e que, como segundo, é necessário, para tanto, que a gestão corporativa decorra da licença social que lhe é dada para criar riquezas e buscar políticas e práticas econômicas que promovam o desenvolvimento sustentável da sociedade. A título de conclusão, destaca-se que os conceitos atribuídos à Responsabilidade Social Corporativa são incompletos em razão da variação de sentido da expressão ao longo do tempo e porque os seus parâmetros ainda são apenas éticos, porquanto carecedores de outros, jurídicos, a serem cumpridos pelas empresas.
FIM DO DIREITO HUMANO À ALIMENTAÇÃO E NUTRIÇÃO ADEQUADAS
Authors: Bruzaca Ruan Didier , Barros Nogueira Danielle Christine
Published: June 2023

Diante da relevância do tema do direito à alimentação e à nutrição adequadas, busca-se, utilizando pesquisa bibliográfica e documental, compreender sua complexidade e seu enquadramento como direito humano fundamental, conforme uma perspectiva crítica, plural e contra-hegemônica. A relevância do tema reside no estado grave de insegurança alimentar que permeia, em especial, a realidade brasileira, necessitando compreender a complexidade do conceito do direito à alimentação e à nutrição adequadas, suas prescrições normativas e a soberania alimentar. O objetivo geral é compreender crítica e contra-hegemonicamente o direito humano à alimentação e à nutrição adequadas. Os objetivos específicos são investigar: (1) os fundamentos do direito humano à alimentação e à nutrição adequadas; (2) as previsões normativas garantidoras do direito em estudo; e (3) a leitura crítica dos direitos humanos e sua relação com o direito à alimentação e à nutrição adequadas. Quanto à metodologia, utiliza-se pesquisa bibliográfica e documental, partindo do materialismo histórico dialético e da teoria crítica dos direitos humanos. Conclui-se que a efetividade dos direitos humanos à alimentação e à nutrição adequadas passa pela soberania alimentar, no sentido de proporcionar não apenas o alimento, mas a alimentação culturalmente adequada à singularidade da população que se está tratando, conforme uma visão crítica desse direito como direito humano.
МЕТОДИЧНИЙ ПІДХІД ДО ВИЗНАЧЕННЯ СТРАТЕГІЇ РОЗВИТКУ МЕРЕЖЕВИХ ПІДПРИЄМСТВ В УКРАЇНІ
Authors: Пахаренко О. В.
Published: June 2023

Стаття присвячена розробці методичного підходу до визначення ефективної стратегії розвитку мережевих підприємств на основі врахування стадії життєвого циклу підприємства, рівня економічної ефективності та ефективності управління мережевою взаємодією, впливу факторів зовнішнього середовища. Запропонований підхід дозволяє здійснювати моніторинг ефективності функціонування підприємств – учасників квазіінтеграційних об’єднань та є основою для розробки перспективних планів розвитку.
ВПЛИВ ІНДУСТРІЇ 4.0 НА РІВЕНЬ КОНКУРЕНТОСПРОМОЖНОСТІ КРАЇН СВІТУ
Authors: Косич М. В. , Александрова О. Ю.
Published: June 2023

Для України нагальною необхідністю є посилення процесів пошуку чинників підвищення національної конкурентоспроможності. Сьогодні у світі ми спостерігаємо процеси переходу до четвертої промислової революції, яка пропонує не тільки  поєднання інформаційно-комунікаційних технологій з промисловим виробництвом, а використання кіберфізичних систем, штучного інтелекту, 3D-друк і т.д.Найбільшою перепоною у  впровадженні досягнень Індустрії 4.0 в Україні є недостатнє фінансування наукових досліджень та розробок, скорочення кількості дослідницьких організацій та самих дослідників. В Україні на розвиток Індустрії 4.0 має вплив державна політика у галузі інновацій й науково-технологічного розвитку, поточний рівень розвитку освіти, науки та технологій.
Spina Bifida Sacralis Occulta from Ancient Greek Sicily (Pozzanghera Necropolis, Leontinoi, 6th–4th Century BC): Anatomical, Anthropological and Ethnomedical Considerations on the Insular Presentation of this Congenital Anomaly
Authors: Melintenda Sebastiano , Varotto Elena , Pappalardo Eleonora , Guzzardi Lorenzo , Papa Veronica , Palermo Dario , Galassi Francesco M.
Published: June 2023

In this article a case of spina bifida sacralis occulta (SBSO) from the Pozzanghera necropolis of the ancient Greek colony of Leontinoi (Sicily) and archaeologically dated to the 6th–4th century BC is morphologically analysed and discussed. An ethnomedical excursus on the knowledge and impact of this condition in Sicilian history is offered. Although SBO is one of the most frequent congenital anomalies in the global palaeopathological record, a comprehensive literature search did not yield results for the history of Sicily before Christ, hence this case enriches existing knowledge on the historical presentation of this vertebral congenital anomaly in this region.
Tooth size discrepancies in Kosovar adolescents with different malocclusion classes
Authors: Zylfiu-Latifi Blertë , Kamberi Blerim , Meštrović Senka
Published: June 2023

The goal of this study was to evaluate tooth size discrepancies in Kosovar adolescents according to the Bolton’s analysis, and to determine the differences between gender and malocclusion classes.
A sample of 400 Kosovar adolescents, aged 13–19 years with various malocclusion categories (class I, II, III) according to the Angle’s classification, was randomly selected. The anterior tooth size ratio, overall tooth size ratio, posterior tooth size ratio, as well as distribution of tooth size discrepancies were assessed. The normality of distribution was assessed by the Kolmogorov-Smirnov test, the differences between genders by the Independent Sample T-test, the Mann-Whitney U-test, and differences among malocclusion groups by ANOVA, the Kruskal-Wallis, and the Dunn’s post-hoc tests.
The tooth size ratios of men and women did not differ significantly. The results also demonstrated significant differences among the malocclusion classes only for the anterior tooth size ratio (p<0.05). The overall and posterior ratios did not differ significantly within malocclusion classes. The percentages of Kosovar subjects with a deviation of more than 2SD from the Bolton average for the anterior and overall ratios were 41.37 and 23.79, respectively.
The genders did not differ significantly regarding tooth size ratios. Among the malocclusion classes, the anterior ratio differed significantly. In Kosovar subjects, tooth size discrepancies tend to be higher compared to Bolton’s averages.
Educación STEM a través del modelado e implementación de impresión 3D dentro de las áreas biomédica e industrial
Authors: Araya-Portuguez Keyner , Torres-Ulate Daniel
Published: June 2023

El modelado e impresión 3D es una tecnología ampliamente utilizada. Puede ser utilizado en diferentes áreas de la industria como para imprimir dispositivos electrónicos como sensores y placas electrónicas, implementaciones dentro del área biomédica para fabricar prótesis y partes del cuerpo humano para preparación quirúrgica, o incluso dentro de industrias por ejemplo aeronáutica y automotriz. Todas estas aplicaciones y su importancia dentro de nuestra sociedad nos hacen requerir un mayor énfasis en las áreas de educación de tallos que involucran estas tecnologías. Por ello es que se considera que es de vital importancia enseñar esta relevante tecnología a personas jóvenes y creativas, que aún no están seguras de que camino tomar en su vida universitaria, un taller sobre estas tecnologías puede darle ese impulso que les falta para poder tomar una decisión y motivarse a innovar mediante la creación de diseños en modelado 3D por software y luego prototipar tanto en software como en impresión 3D.
Comunidad de indagación, una experiencia para fortalecer el pensamiento crítico, cuidadoso y creativo
Authors: Mesa Doris
Published: June 2023

En este artículo se exponen los resultados acerca de la experiencia de conformación de una comunidad de indagación interesada en desarrollar las dimensiones del pensamiento crítico, cuidadoso y creativo en la Línea de Profundización Pensamiento y Literatura integrada por estudiantes de 6° de bachillerato (Tribu) a 11° (Samadhi) de la Fundación Pedagógica Rayuela Tunja en el 2021. La experiencia responde a reflexionar sobre la práctica pedagógica al impulsar, resignificar la voz y el estilo de escritores creativos para fortalecer su capacidad de pensamiento y expresión enfocada en 18 estudiantes. La investigación es de carácter cualitativo; los instrumentos de recolección de información contienen: audios, videos, documentos, así como evidencias de planes de discusión, y producciones de los estudiantes. En los resultados se describen ejercicios de: escritura, lectura y planes de discusión, que permiten analizar los procesos desarrollados a partir de la categoría de pensamiento multidimensional planteada por Matthew Lipman. Se concluye que es necesario hacer del aula o los escenarios virtuales una indagación permanente, que permita un acontecimiento de experiencias de lectura, escritura y diálogo, que permitan reclamar el derecho a pensar y proponer desde la diferencia.
Strategy for Action to Save Men and Support Responsible Fatherhood
Authors: Rostovskaya Tamara
Published: June 2023

The current demographic agenda ofthe Russian Federation includes the promotion of traditional family values, where a special role is assigned to the formation and development of the institution of a prosperous (large) family with chldren, and support for responsible fatherhood. As part of these tasks, in March 2023, the members of the Scientific Council "Demographic and Migration Problems of Russia" under the Department of Social Sciences of the Russian Academy of Sciences, on their own initiative, developed the "Strategy for Action to Save Men and Support Responsible Fatherhood".
Russia’s Science Policy in 2018–2022: Controversial Signals
Authors: Dezhina Irina
Published: June 2023

The article analyzes the Russian science policy that has been implemented during last five years, after setting new goals in 2018. Science policy measures are examined in the projection of three actors. The first actor is the government that sets goals, systems of management and coordination, and allocates the funds. The second actor is the Russian Academy of Sciences, which performs an expert function. The third actor is university science, which has become the main beneficiary of state support in recent years. The aim of the article is to identify the key directions of the country’s science policy in projections of the readiness of the science system to the radically changed geopolitical conditions that have emerged in 2022.
During the last five years, the system of science management has evolved towards increased centralization of power. Such system allows concentrating resources on key tasks. However, such tasks that would need centralized effort were not set. The main objectives of the science policy focused on the diversification and integration of the Russian science into the international scientific community (through the improvement of positions in the international ratings, growth of publications indexed in international databases, encouraging academic mobility). The result of the contradicting government policy was unpreparedness of the science sector to sanctions. The state was able to undertake only actions of immediate reaction; the time was lost to develop measures aimed at existence in isolation from key world scientific powers.
Book clubs as strategy for increasing nutrition knowledge among general population
Authors: López-Díaz María Teresa , Romero Irene , Martín María Ángeles , Sánchez-Ballesta María Teresa , Gómez-Estaca Joaquín , Álvarez-Cilleros David , Ramos Sonia , Mesias Garcia Marta , Peñas Elena , Pérez-Jiménez Jara
Published: June 2023

Introduction: The spread of false news related to nutrition shows the need to provide general public validated information on food and health, inducing them to follow healthy dietary habits. Objective: To assess whether attendance to book clubs devoted to scientific disseminations books is a useful strategy for improving nutritional knowledge among the population. Methodology: 65 adults participated in a reading club, attending a research center once a month for 4 months to talk about informative scientific books on food/nutrition. The knowledge of the participants was monitored through a survey performed in all the sessions of the club. Results: Participants were mostly female with university studies. Attendance to the book clubs caused a significant increase (P < 0.05) in the number of correct answers on a questionnaire about common misbeliefs on the topics covered in the discussed books. Participants showed a high degree of satisfaction with the activity and willingness to read more scientific dissemination books, even when most of them were not previously usual readers. Conclusions: Book clubs based on popular science books and led by scientists with expertise in the field could increase nutritional knowledge among general population, which should be further explored in different socioeconomic contexts.
Os silêncios na arte contemporânea sul-africana a partir de Willie Bester
Authors:   Universidade de São Paulo, Tornich Carolina de Campos
Published: June 2023

Willie Bester é um artista sul-africano que tem sua história marcada pelo silêncio. Nascido em Montagu, próximo à Cidade do Cabo em 1956, é filho de mãe xhosa e pai classificado como “coloured” pela classificação elaborada pelo regime do apartheid. Sua origem demonstra uma fuga ao comum, já que na época não esperava-se que houvesse união entre "diferentes". Bester, fruto de tal união, foi classificado como "other coloure" e viveu segregado em uma township durante toda a sua infância.
Vicissitudes dos espaços Afro-brasileiros: as Igrejas de Nossa Senhora do Rosário dos Pretos da Cidade de São Paulo e de suas freguesias
Authors:   Universidade de São Paulo, Santos Fabricio Forganes
Published: June 2023

A religião e a escravidão foram dois instrumentos imprescindíveis para a concretização dos propósitos da Coroa Portuguesa nos seus processos de colonização na América. O objetivo final era a extração das riquezas e a consequente geração de lucros para o Rei, contudo o acordo estabelecido com a Ordem de Christo, principal instituição a financiar as navegações, teria como uma das premissas a implantação da fé católica nas colônias através da evangelização dos novos povos.
O bosque enquanto masmorra: alegorias da ambiência selvática na pintura de Eduardo Berliner
Authors:   Universidade Estadual de Campinas, Medeiros Gabriel Morais
Published: June 2023

Este trabalho propõe, em termos gerais, uma interpretação da categoria de ambiência do bosque/floresta/parque na recente produção pictórica de Eduardo Berliner (RJ, 1978). Chamamo-la categoria de ambiência por considerarmos os ícones que compõem esse tipo de cenário um motivo alegórico, com claves sêmicas constantes, que surgirão em determinadas obras do artista, compondo um sistema iconográfico coerente.
O nu feminino em Suzanne Valadon
Authors:   Universidade Estadual de Campinas, Siqueira Marina Silva e
Published: June 2023

O presente artigo pretende apresentar algumas questões que surgiram no curso de minha pesquisa de mestrado, "O nu feminino em Suzanne Valadon: Nus (1919) no acervo do MASP", iniciada em 2017. Abordarei aqui as principais características da obra de Suzanne Valadon, conforme apontadas pela crítica do início do século XX bem como pela literatura posterior sobre a artista, aplicadas ao nu feminino. O objetivo é demonstrar, por meio de algumas obras selecionadas, o desenvolvimento e as transformações na forma de trabalhar o nu ao longo da obra da artista.
Fotomontagem no Brasil, primeira metade do século XX
Authors:   Universidade Estadual de Campinas, Sacchettin Priscila
Published: June 2023

A comunicação tem como proposta apresentar alguns exemplos de trabalhos envolvendo a fotomontagem ocorridos no Brasil, durante a primeira metade do século XX. As informações aqui fornecidas inserem-se no âmbito de minha pesquisa de doutorado, na qual investigo as fotomontagens publicadas por Jorge de Lima em 1943, no álbum A pintura em pânico, frequentemente considerado pioneiro nessa técnica. O intuito desta fala é relativizar tal afirmação, mostrando que havia já uma produção local de fotomontagens, ainda que não em âmbito artístico.
Oswald de Andrade entre a Negra e Jack Johnson: o discurso racial e o modernismo paulista
Authors:   Universidade de São Paulo, Virava Thiago Gil de Oliveira
Published: June 2023

Em alguns dos principais textos em que Oswald de Andrade discute as artes visuais na década de 1920, especialmente durante o período de formulação do "futurismo paulista" que produziu a Semana de Arte Moderna, em 1922, encontram-se posicionamentos sobre a questão racial no Brasil. O que este texto apresenta é uma primeira tentativa de aproximação dessa discussão, centrada em três textos publicados por Oswald de Andrade, entre 1914 e 1923, relativamente pouco conhecidos se comparados a seus manifestos,
Cemitério também tem arte: considerações sobre o estudo da arte tumular no Brasil
Authors:   Centro Universitário Assunção, Bortulucce Vanessa Beatriz
Published: June 2023

Nossa proposta neste breve ensaio é realizar uma reflexão acerca dos estudos sobre a arte tumular no Brasil, apontando algumas questões ligadas a este campo específico de produção visual. As pesquisas sobre arte cemiterial são extremamente esparsas e irregulares em nosso país; são praticamente ausentes nas teses e artigos acadêmicos, nos livros e nos debates entre os historiadores da arte.
O Surrealismo e as mulheres: uma análise através da moda
Authors:   Universidade Estadual de Campinas, Prudente Aline Barbosa da Cruz
Published: June 2023

O surrealismo, inicialmente um movimento literário, nasce com a publicação do primeiro manifesto surrealista em 1924 escrito por André Breton (1896 – 1966). Nesta obra, o autor propõe uma busca pela o automatismo psíquico puro para exprimir o funcionamento real do pensamento, seja pela forma escrita, ou de qualquer outra maneira, incentivando o uso desinteressado do pensamento e dos sonhos.
Fragmentation of Dakwah Media: Exploring Exclusive Islam in Indonesia Post-Reform Popular Islamic Novels
Authors: Kustiawan Muhamad Taufik , Rasidin Mhd. , Witro Doli , Jalaluddin Mufti Labib
Published: June 2023

This article aims to highlight Islamic exclusivism in the form of popular Islamic novelS for children’s reading books in Indonesia after the reform of 1998. Building on the media theory of Gill Branston and Roy Stafford, this study explains Islamic pop novels as Islamic educational materials from a semiotic approach, structuralism, and critical discourse analysis. In particular, this study uses qualitative research methods by descriptively analyzing the reading of Islamic pop novels spreading in the Qur’anic Education Centre in Central Java. The results showed that since the Reformation, the movement used books, newsletters, magazines, and children’s readings of Islamic pop novels to shape the religious thoughts of urban Muslim children and youth in Indonesia. There is hardly a story related to diversity, the value of tolerance, and mutual respect between religious people in those materials. The awareness of religious comprehension in children's reading seems exclusive. It must be realized by various parties that the media utilizing Islamic literature is very influential on the growth and development of children's religious thinking in the educational space in the metropolis.
IMPLEMENTATION OF TECHNOLOGY FOR IMPROVING THE QUALITY OF SEGMENTATION OF MEDICAL IMAGES BY SOFTWARE ADJUSTMENT OF CONVOLUTIONAL NEURAL NETWORK HYPERPARAMETERS
Authors: Prochukhan Dmytro
Published: June 2023

Background. The scientists have built effective convolutional neural networks in their research, but the issue of optimal setting of the hyperparameters of these neural networks remains insufficiently researched. Hyperparameters affect model selection. They have the greatest impact on the number and size of hidden layers. Effective selection of hyperparameters improves the speed and quality of the learning algorithm. It is also necessary to pay attention to the fact that the hyperparameters of the convolutional neural network are interconnected. That is why it is very difficult to manually select the effective values of hyperparameters, which will ensure the maximum efficiency of the convolutional neural network. It is necessary to automate the process of selecting hyperparameters, to implement a software mechanism for setting hyperparameters of a convolutional neural network. The author has successfully implemented the specified task.

Objective. The purpose of the paper is to develop a technology for selecting hyperparameters of a convolutional neural network to improve the quality of segmentation of medical images..

Methods. Selection of a convolutional neural network model that will enable effective segmentation of medical images, modification of the Keras Tuner library by developing an additional function, use of convolutional neural network optimization methods and hyperparameters, compilation of the constructed model and its settings, selection of the model with the best hyperparameters.

Results. A comparative analysis of U-Net and FCN-32 convolutional neural networks was carried out. U-Net was selected as the tuning network due to its higher quality and accuracy of image segmentation. Modified the Keras Tuner library by developing an additional function for tuning hyperparameters. To optimize hyperparameters, the use of the Hyperband method is justified. The optimal number of epochs was selected - 20. In the process of setting hyperparameters, the best model with an accuracy index of 0.9665 was selected. The hyperparameter start_neurons is set to 80, the hyperparameter net_depth is 5, the activation function is Mish, the hyperparameter dropout is set to False, and the hyperparameter bn_after_act is set to True.

Conclusions. The convolutional neural network U-Net, which is configured with the specified parameters, has a significant potential in solving the problems of segmentation of medical images. The prospect of further research is the use of a modified network for the diagnosis of symptoms of the coronavirus disease COVID-19, pneumonia, cancer and other complex medical diseases.
Algorithms of statistical anomalies clearing for data science applications
Authors: Pysarchuk Oleksii , Baran Danylo , Mironov Yurii , Pysarchuk Illya
Published: June 2023

The paper considers the nature of input data used by Data Science algorithms of modern-day application domains. It then proposes three algorithms designed to remove statistical anomalies from datasets as a part of the Data Science pipeline. The main advantages of given algorithms are their relative simplicity and a small number of configurable parameters. Parameters are determined by machine learning with respect to the properties of input data. These algorithms are flexible and have no strict dependency on the nature and origin of data. The efficiency of the proposed approaches is verified with a modeling experiment conducted using algorithms implemented in Python. The results are illustrated with plots built using raw and processed datasets. The algorithms application is analyzed, and results are compared.
Exploring Preservice Teachers’ Classroom Management Skills during Teaching Practice: Perspectives of University Supervisors
Authors: Dube Celimpilo Mbusiseni , Mncube Dumsani , Uleanya Chinaza
Published: June 2023

South African universities have been under tremendous pressure to improve preservice teachers’ quality and implement the Minimum Requirement for Teacher Education (MRTEC) as a direct response to the outcry of poor training of teachers. Preservice teachers face classroom management challenges during their teaching practice. Therefore, this study aims to identify the gap in the training programme and propose alternative pathways that might improve classroom practice to enable preservice teachers to bridge the gap between theory and practice. This study draws on classroom observation by university supervisors during teaching practice. Six university supervisors were purposively and conveniently sampled to participate in this study. Online narrative reflections, Zoom group meetings, and WhatsApp one-on-one semi-structured interviews were used to generate data as part of qualitative inquiry. Findings identify weak coordination between fundamental modules and co-modules as the hindrance to effective classroom management. Yet, university supervisors are critical of the poor implementation of classroom management skills as though they are immune from the training process. Therefore, this study recommends that the Teaching Practice Unit introduce a compulsory practical demonstration centre that will use nearby schools before practice teaching officially commences.
Adopting a Soft Transdisciplinary Approach via Inquiry/Project Based Learning: A Focus on Legal Education
Authors: Greenfield Steve , Niemczyk Ewelina
Published: June 2023

Globally, the COVID-19 pandemic brought to the fore fundamental changes and challenges in education. This is also clear within legal education in BRICS countries and beyond, where issues emerged but created space for effective ways forward. In alignment with the special issue theme, this paper provides a vision for post-pandemic education – in this case, in one discipline, namely legal education. Based on an international literature review, it is argued that to deliver appropriate skills and create well-rounded graduates effectively, there is a need to rework the vision of law as a single discipline. Thus, considering the contemporary challenges to legal education described in this paper, a different approach to the curriculum is required in which support for the development of vital skills such as creativity, critical thinking and complex problem-solving is maximised. Furthermore, attention needs to be devoted to adopting a transdisciplinary perspective delivered through inquiry-based learning. This requires thinking about problem-solving from multiple viewpoints and seeking out tools, practices and pieces of knowledge from multiple fields to arrive at better questions and solutions.
Space Theory
Authors: Chen S.
Published: June 2023

The author introduces a novel theoretical framework that suggests matter and energy are both converted from curved space. In Space Theory, gravitation is generated by the flow of space, instead of being transmitted by the graviton as in String Theory. This theory also suggests that Newton's gravitational constant, denoted as G, may not be truly constant but could vary over time. The equivalent equation of space is S=Ec2=mc4, and the gravitation of hollow sphere space is Sμν=4πGm=(4/3)π((r+a)3-r3).
Primordial Planets with an Admixture of Dark Matter Particles and Baryonic Matter
Authors: Kiren OV , Kenath Arun , Sivaram Chandra
Published: June 2023

It has been suggested that primordial planets could have formed in the early Universe and the missing baryons in the Universe could be explained by primordial free-floating planets of solid hydrogen. Many such planets were recently discovered around the old and metal poor stars and such planets could have formed at early epochs. Another possibility for missing baryons in the Universe could be that these baryons are admixed with DM particles inside the primordial planets. Here we discuss the possibility of admixture of baryons to the DM primordial planets discussed earlier. We consider gravitationally bound DM objects with the DM particles constituting them varying in mass from 20 to100GeV. Different fractions of DM particles mixed with baryonic matter in forming the primordial planets are discussed. For the different mass range of DM particles forming DM planets, we have estimated the radius and density of these planets with different fractions of DM and baryonic particles. It is found that for heavier mass DM particles with the admixture of certain fractions of baryonic particles, the mass of the planet increases and can reach or even substantially exceed Jupiter-mass. The energy released during the process of merger of such primordial planets is discussed. Also the energy required for the tidal breakup of such an object in the vicinity of a black hole is also discussed.
Cross-species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances (PFAS)
Authors: Beccacece Livia , Costa Filippo , Pascali Jennifer Paola , Giorgi Federico Manuel
Published: June 2023

In the recent decades, per- and polyfluoroalkyl substances (PFAS) have garnered widespread public attention due to their persistence in the environment and detrimental effects on the health of living organisms, spurring the generation of several transcriptome-centered investigations to understand the biological basis of their mechanism. In this study, we collected 2144 publicly available samples from 7 distinct animal species to examine the molecular responses to PFAS exposure and to determine if there are conserved responses. Our comparative transcriptional analysis revealed that exposure to PFAS is conserved across different tissues, molecules and species. We identified and reported several genes exhibiting consistent and evolutionarily conserved transcriptional response to PFAS, such as ESR1, HADHA and ID1, as well as several pathways including lipid metabolism, immune response and hormone pathways. This study provides the first evidence that distinct PFAS molecules induce comparable transcriptional changes and affect the same metabolic processes across inter-species borders. Our findings have significant implications for understanding the impact of PFAS exposure on living organisms and the environment. We believe that this study offers a novel perspective on the molecular responses to PFAS exposure and provides a foundation for future research into developing strategies for mitigating the detrimental effects of these substances in the ecosystem.
Molecular Characterization of a Male-specific SoxE Gene in the Swimming Crab, Portunus trituberculatus, and Transcriptional Interaction with Insulin-like Androgenic Gland Hormone
Authors: Jiang Qinghua , Xu Dongjie , Wang Mengen , Xie Xi , Zhu Dongfa
Published: June 2023

The Sry-related HMG-box (Sox) family is a group of transcriptional regulators that play a critical role in many important developmental processes in both vertebrates and invertebrates. In aquatic animals, the function of Sox genes on sexual development has been gained particular attentions. The present study reported the molecular characterization of a Sox member (PtSoxE) in the swimming crab, Portunus trituberculatus, and tissue distribution analysis showed it was male-specific. Since the most highly expression of PtSoxE was found in the androgenic gland (AG), its relation to the insulin-like androgenic gland hormone (IAG) was further investigated. The PtSoxE siRNA caused a significant decrease in IAG expression in both AG and testis, whereas PtSoxE expression could be induced by treating with AG homogenate and rIAG. The result suggested a transcriptional interaction between PtSoxE and IAG. In addition, PtSoxE expression showed a closely positive correlation with several reported spermatogenesis-related genes, suggesting its involvement in testicular development of P. trituberculatus.
An Investigation of Anisotropic Fatigue Properties of Laser Additively Manufactured Ti-6Al-4V under Vibration Loading
Authors: He Yan , Huang Wei , Guo Weiguo , Li Yanping , Zhao Sihan , Lin Dong
Published: June 2023

Laser additively manufactured (LAM) Ti–6Al–4V alloy has huge application potential in aerospace structural parts such as turbine blades. However, there are few studies on the fatigue properties of such LAM parts under vibration loading, particularly with regard to anisotropy. In this paper, vibration fatigue properties of LAM Ti-6Al-4V by laser melted deposition process were investigated along the transversely deposited (TD) direction and parallelly deposited (PD) direction. Through the first-order bending vibration experiments, LAM Ti-6Al-4V alloy exhibits obvious anisotropic fatigue properties and significant dispersion in fracture position. The fracture morphology analysis reveals that the vibration fatigue failure was mainly dominated by the LAM process-induced defects and the microstructure. For the LAM samples without defects at crack initiation sites, the fatigue behavior is controlled by the prior β columnar grains with preferential orientation, which leads to enhanced fatigue crack propagation resistance for the PD samples. For the LAM samples with defects at initiation sites, having lower fatigue lives, the fatigue anisotropy strongly depends on the projection area of the lack-of-fusion defects relative to the loading direction, resulting in better fatigue performance for the TD samples.
Dielectric Resonator Metasurface-based THz Biosensor for Rapid Viruses Detection
Authors: Rmili Hatem , Yahyaoui Ali , Yousaf Jawad , Al-Hashmi Anas , Sobahi Nebras , Hakim Bandar
Published: June 2023

This study reports the design of a dielectric resonator (DR) metasurface-based terahertz biosensor for rapid and accurate detection of different kinds of viruses (H1N1, SARA-COV-2, etc.). The characterization of the sensor is done by analyzing its absorbance properties with and without the presence of the H1N1 virus layer of different concentrations and electrical properties in the frequency range of 2.4 THz to 3 THz. A full-wave EM model of the sensor is designed using CST MWS software. The geometrical parameters of the proposed biosensor, as well as its dielectric constant of the virus swab, are varied to achieve good performance with an absorption level close to 1 (100%). A significant change in the resonating pick-up frequency owing to the variation in the effective refractive index of the realized sensor ensures the detection and classification of the different concentrations of the same or different viruses. The presented design could be used for the rapid detection of viruses with the added advantages of contactless, label-free, and accurate identification of different concentrations of viruses.
Co-Variational Inequality Problem involving Two Generalized Yosida Approximation Operators
Authors: Ahmad Rais , Wang Yuanheng , Ishtyak Mohd , Rizvi Haider Abbas , Rajpoot Arvind Kumar
Published: June 2023

In this paper, we study a co-variational inequality problem involving Yosida approximation operators in real uniformly smooth Banach space and define an iterative method to obtain its solution. We prove some properties of Yosida approximation operator for our purpose, that is strongly accretivity and Lipschitz continuity. An existence as well as convergence result is proved for co-variational inequality problem involving Yosida approximation operators using the concept of nonexpansive sunny retraction.
Asymmetric Kernel Density Estimation for Biased Data
Authors: Kakizawa Yoshihide
Published: June 2023

Nonparametric density estimation for nonnegative data is considered in a situation where a random sample is not directly available but the data are instead observed from the length-biased sampling. Due to the boundary bias problem of the location-scale kernel, the approach in this paper is an application of asymmetric kernel. Two nonparametric density estimators are proposed. The mean integrated squared error, strong consistency, and asymptotic normality of the estimators are investigated. Some simulations illustrate the finite sample performance of the estimators.
Study on the Mechanism of High-Efficiency Rock Breaking by Hydraulic Jet Based on Explicit Dynamics
Authors: Bi Gang , Wang Xin , Han Fei , Wu Jiemin , Yuan Peijie , Fu Shuaishuai , Ma Ying
Published: June 2023

High-efficiency rock breaking by hydraulic jetting is the key to radial horizontal drilling technology. In order to improve the drilling efficiency of hydraulic jet rock breaking in radial horizontal wells, based on LS-Dyna display dynamics, a numerical simulation model of single nozzle jet rock breaking is established to analyze the influence of different nozzle parameters on rock breaking effect. Then, the numerical simulation model of the spin multi-nozzle jet bit is established, and the influence of different rotation speeds on the rock breaking effect of the jet bit is analyzed. Finally, the rock breaking drilling characteristics of the spin multi-nozzle jet bit and the conventional multi-nozzle jet bit are compared and analyzed. The results show that when the jet impacts the rock surface, the larger the inclination angle is, the larger the rock breaking width formed by the jet is. The smaller the dip angle, the greater the rock breaking depth. When the inclination angle is greater than 60 °, it is difficult to meet the needs of reaming. The width and depth of the nozzle gradually increase with the increase of the diameter. When the nozzle diameter is greater than 1.3mm, the growth rate of rock breaking depth begins to decrease. The optimum nozzle diameter is 1.3 mm. When v = 50m / s, the damage caused by the jet to the rock surface is very small, because the condition of rock fracture is not reached at this time. This shows that there is a critical value of the water jet impact velocity, and only when the velocity is reached, the rock will break. When the velocity is v = 150m / s, v = 200m / s, v = 250m / s, v = 300m / s, the rock breaks. At the same time, the higher the speed, the higher the degree of rock fracture, the greater the fracture depth, the greater the fracture area, the better the fracture effect. The tangential and radial velocity of the jet increases the shear and tensile failure rate of the sample, and improves the rock breaking efficiency of the jet, which has certain guiding significance for improving the rock breaking drilling efficiency of radial horizontal well drilling.
Quaternion Quantum Mechanics II: Unraveling the Mysteries of Gravity and Dirac Equation within the Planck-Kleinert Crystal
Authors: Danielewski Marek , Sapa Lucjan , Roth Chantal
Published: June 2023

The correspondence between classical and quaternion quantum equations, permits considering the universe (vacuum) as an ideal elastic solid. Elementary particles would have to be standing or soliton-like waves. Tension induced by the compression and twisting of the elastic medium would increase the energy density, consequently generate a gravity forcing and affect the wave speed. Consequently the gravity could be described by an index of refraction.
Theory was created by combining the Cauchy model of the elastic continuum with the Planck-Kleinert crystal hypothesis. The quaternion-imaginary Lagrange’an, the quaternion motion equation and the quaternionic oscillator allowed deriving:
- The Schrödinger equation from the functional integral, which identifies the quaternion-imaginary quantum Hamiltonian.
- The 2nd order wave equation system describing both the bosons and the gravity in terms of quaternionic Poisson equation.
- The first order quaternionic wave equation system.
- The family of the second order wave equation systems describing both the particles and the generated quaternionic force-fields (four-potentials).
- The fundamental Planck and gravity constants.
- The quaternionic continuity equation in an ideal elastic solid.
Exploring Silybin B as a FOXM1 Inhibitor in Glioblastoma Stem Cells: Molecular Docking, ADMET, and Molecular Dynamics Approaches
Authors: Swati Kumari , Quazi Sameer , Srivastava Rashi , Panda Siva Prasad , Agrawal Kirti , Parkash Anand , Kumar Dhruv
Published: June 2023

Glioblastoma multiforme (GBM) is a highly heterogeneous brain tumor with limited treatment options and a poor prognosis. Cancer stem cells (CSCs) have emerged as a critical factor in GBM resistance and management, contributing to tumor growth, heterogeneity, and immunosuppression. The transcription factor FOXM1 has been identified as a key player in the progression, spread, and therapy resistance of various cancers, including GBM. In this study, researchers conducted structure-based in silico screening to identify natural compounds that could target the DNA-binding domain (DBD) of the FOXM1 protein. Through molecular docking analyses, identified Silybin B as a potential inhibitor of FOXM1, exhibiting strong interaction with the protein. MD simulations were performed to validate the binding stability of the FOXM1-Silybin B complex. The study provides valuable insights into the potential of Silybin B as a FOXM1 inhibitor and its ability to induce senescence in GBM stem cells. These findings contribute to the development of structure-based design strategies for FOXM1 inhibitors and innovative therapeutic approaches for the treatment of Glioblastoma.
Postoperative Seizure Prophylaxis in Meningioma Resection: A Systematic Review and Meta-Analysis
Authors: Batista Sávio , Bertani Raphael , Palavani Lucca B , Oliveira Leonardo de Barros , Borges Pedro , Koester Stefan W , Paiva Wellingson Silva
Published: June 2023

Background: Seizures in the early postoperative period may impair patient recovery and increase risk of complication. The aim of this study is to determine whether there is any advantage in postoperative seizure prophylaxis following meningioma resection. Methods: This systematic review was conducted in accordance with PRISMA guidelines. PUBMED, Web of Science, Embase, Science Direct, and Cochrane were searched for papers until April 2023. Results: Among 9 studies, a total of 3,249 were evaluated patients, of which 984 patients received antiepileptic drugs (AEDs). A comparison between patients who received AEDs and those who did not showed a non-significant differences between both groups (RR 1.22, 95% CI 0.66 to 2.40; I² = 57%). Postoperative seizures occurred in 5% (95% CI: 1% to 9%) within the early time period (<7 days), and 9% (95% CI: 1% to 17%) in the late time period (>7 days), with significant heterogeneity (I² = 91% and 97% respectively). In seizure-naive patients, the rate of postoperative seizures was 2% (95% CI: 0% to 6%) in the early period and increased to 6% (95% CI: 0% to 15%) in the late period. High heterogeneity led to the use of random-effects models in all analyses. Conclusion: The current evidence does not provide sufficient support for the effectiveness of prophylactic AED medications in preventing postoperative seizures in patients undergoing meningioma resection. This underscores the importance of considering diagnostic criteria and conducting individual patient analysis to guide clinical decision-making in this context.
Electrochemical Biosensing Methods for Detecting Epigenetic Modifications
Authors: Huang Ziyue , Dou Yanzhi , Su Jing , Li Tie , Song Shiping
Published: June 2023

Epigenetic modifications are closely related to diseases and physiological health, mainly including DNA methylation, RNA methylation, histone acetylation, and non-coding RNA. Recently, a large amount of research has been conducted on the detection of epigenetic modifications. Electrochemical biosensors, with their low cost, high sensitivity, high compatibility, and simple operation, have been widely used in the detection of epigenetic biomarkers. This review discusses the detection of epigenetic biomarkers using different electrochemical sensing methods. Here we discuss various aspects, including free labels, signal labeling, signal amplification, nano-based electrodes, and the combined use of other methods. By summarizing the existing electrochemical detection methods for epigenetic modifications, this review also proposes the future development trends and challenges for electrochemical biosensors in this field.