bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluasi Sistem Pelaporan Insiden Keselamatan Pasien Dengan Metode HMN Di Rumah Sakit
Authors: Toyo Eleonora Maryeta , Leki Karol Giovani Battista , Indarsari Ferika , Woro Suwito
Published: October 2022

Keselamatan pasien di rumah sakit adalah sistem pelayanan yang memberikan asuhan pasien menjadi lebih aman dalam mengukur risiko, identifikasi dan pengelolahan risiko terhadap analisa insiden, kemampuan untuk belajar dan menidaklanjuti insiden serta menerapkan solusi untuk mengurangi risiko.Tujuan dalam penelitian ini adalah untuk mengevaluasi sistem pelaporan insiden keselamatan pasien dengan menggunakan metode HMN (Health Metrics Network) yang mencakup aspek segi input, segi proses, dan segi output. Penelitian ini merupakan studi deskriptif observasional dengan rancang bangun cross sectional dan data kualitatif. Pengumpulan data dilakukan dengan wawancara, observasi, dan telaah dokumen. Hasil dan kesimpulan penelitian menunjukkan bahwa komponen-komponen evaluasi sistem pelaporan insiden yaitu sumber daya sistem informasi kesehatan, indikator kesehatan, sumber data, manejemen data, produk informasi, dan penggunaan informasi kesehatan sudah sesuai dengan peraturan menteri kesehatan no. 11 tahun 2017 tentang keselamatan pasien dan buku panduan pelaporan insiden keselamatan pasien yang dikeluarkan oleh tim KKP-RS tahun 2015. Kata kunci: Keselamatan Pasien, Pelaporan Insiden, HMN, Rumah Sakit
Canine mitral valve size as measured by computed tomography
Authors: Gordon-Evans Wanda J. , Montin K. Helena , Ober Christopher P. , Coryell Jessi L. , Castilla Andrea E.
Published: October 2022

OBJECTIVE

To measure the mitral annulus in dogs. Our hypothesis was that mitral measurement would be possible and consistent among observers using CT.

SAMPLE

Thoracic CT scans of dogs without known heart disease.

PROCEDURES

Five trained investigators measured 4 aspects of the mitral valve and the fourth thoracic vertebrae (T4) length using multiplanar reformatting tools. Ten randomly chosen animals were measured by all investigators to determine interobserver reliability.

RESULTS

There were 233 CT scans eligible for inclusion. Dogs weighed 2 to 96 kg (mean, 28.1 kg), with a variety of breeds represented. Golden Retrievers (n = 28) and Labrador Retrievers (n = 37) were overrepresented. The intraclass correlations were all greater than 0.9, showing excellent agreement between observers. The means and SDs of each measurement were as follows: trigone-to-trigone distance, 17.2 ± 4.7 mm; the remaining circumference, 79.0 ± 17.5 mm; commissure-to-commissure distance, 30.8 ± 6.5 mm; septal leaflet-to-lateral leaflet distance, 26.3 ± 6.0 mm; T4 length, 16.9 ± 3.1 mm; and the total circumference normalized by T4, 5.7 ± 0.7 mm.

CLINICAL RELEVANCE

This study provides information that may help in the development of future treatment for mitral valve dysfunction and subsequent annular enlargement.
The Calcium Loading Test in Primary Hyperparathyroidism – Does it Provide Useful Information?
Authors: Bakalov D. , Boyanov M.
Published: October 2022

Objective: to describe the results from intravenous calcium loads in patients with suspected PHPT.

Methods: This was a retrospective cross-sectional study with inpatients’ data review. Baseline serum calcium, phosphates, magnesium, creatinine, alkaline phosphatase, beta-crosslinks were recorded. The calcium loading had been performed after an overnight fasting. Calcium gluconate 0.25 mmol/kg body weight (10 mg/kg) dissolved in 0.9% Sodium Chloride was infused intravenously for 3 hours. Blood samples for total serum calcium, phosphates and iPTH were drawn before and up to 60 minutes after the calcium load. The intact parathyroid hormone (iPTH) and 25(OH)-vitamin D were determined by electro-hemi-luminescence (Elecsys, Roche Diagnostics). The PTH inhibition rate in % (PTH-IR), the calcium increment, the ratio R (ΔPTH/ΔCalcium) and the product P (calcium X PTH at test end) were calculated.

Results: 23 patients with PHPT had complete data from calcium loading tests. The PTH suppression was < 30% in 17.4% of the participants, 30% to 50% – in 21.7% and > 50% in the remaining 60.9%. One patient displayed PTH suppression > 75%. The Ratio R was < 4.0 in all but one patient. Product P was above 1100 mg/dl x pg/ml in 9 participants (39.1%). Sixteen patients (69.6%) had positive localization results from US or SPECT-CT. The level of PTH suppression was not related to any parameter except the volume of the suspected lesion.

Conclusion: The calcium loading test was unable to differentiate the forms of PHPT. It did not add great value in the diagnostic work-up of PHPT.
The Prevalence of Asymptomatic Hyperuricemia in Patients with or Without Psoriatic Arthritis is Associated with a Similar Cardiovascular Risk
Authors: Gancheva R. , Kundurzhiev T. , Sheitanov I. , Petranova Tz. , Kolarov Zl. , Yankova P. , Nikolova M. , Kundurdzhiev A.
Published: October 2022

Aim: To investigate the association between cardiovascular burden and monosodium urate (MSU) deposits in the joints of patients with asymptomatic hyperuricemia and no evidence of arthritis and subjects with psoriatic arthritis and hyperuricemia.

Patients and methods: A single-center, cross-sectional study including 52 individuals: 39 with asymptomatic hyperuricemia and 13 with psoriatic arthritis and hyperuricemia. All patients underwent ultrasound of the joints by which the presence or absence of MSU crystal deposits was assessed. Subjects underwent transthoracic echocardiography by which left ventricular mass index (LVMI) was estimated. Intima-media thickness (IMT) of the common carotid arteries was measured and the presence of atherosclerotic plaques was registered.

Results: We found no difference in the distribution of cardiovascular risk factors between the two groups. Further, no difference in their distribution was found between those who were not treated and those who were treated with urate-lowering medications. The frequency of articular MSU deposits was similar between non-allopurinol-treated and allopurinol-treated individuals (p = 0.554). There was no difference in the frequency of articular deposits between benzbromarone recipients and non-recipients (p = 0.396). We observed no connection between articular MSU deposits and LVMI (p = 0.625), IMT (p = 0.117) and atherosclerotic plaques (p = 0.102). Among untreated and treated with urate-lowering drugs there was no difference in LVMI (p = 0.063), IMT (p = 0.975) and plaque distribution (p = 1.000).

Conclusion: We can assume that in patients with asymptomatic hyperuricemia and no evidence of arthritis and in subjects with psoriatic arthritis and asymptomatic hyperuricemia, only the prescription of urate-lowering medications for reduction of urate load and cardiovascular risk is not sufficient.
Anatomical Variations of the Maxillary Sinus – A Cone Beam Computed Tomography Study
Authors: Asan M. F. , Castelino R. L. , Babu S. G. , Darwin D.
Published: October 2022

Objectives: The knowledge of the normal morphology of the maxillary sinuses and their variations is important for maxillofacial radiologists to achieve a better evaluation and delineation of pathologies and for pre-implant evaluation of the maxilla.

The aim of our study was to evaluate anatomical variations of maxillary sinuses using Cone Beam Computed Tomography (CBCT).

Materials and methods: 150 CBCT images where bilateral maxillary sinuses were scanned were included in the study following the inclusion and exclusion criteria. 75 CBCT scans each of males and females were studied using the Planmeca Romexis software (Version 4.6.2). Multiplanar images were searched for the presence of anatomical variations such as septae, haller cells and ethmomaxillary sinus. The data were subjected to Chi square test using SPSS software to compare and relate gender and site based differences in the occurrence of the anatomical variations.

Results: Sinus septa was the predominant variation in both males and females with significantly higher prevalence in females and on the right side. An ethmomaxillary sinus was seen significantly more often in males, while Haller cells did not show any gender based differences in their occurrence. Ethmomaxillary sinus and Haller cells showed no difference in occurrence on the right and left side.

Conclusions: Anatomic variations of the maxillary sinuses are a common finding. It necessary for the clinicians to be familiar with these variations to avoid clinical complications especially in cases of implant placements.
Acute Kidney Injury and Acute Renal Failure in Coronaviral Infection
Authors: Nikolova M. , Angelova I. , Kotseva V. , Kostadinova A. , Genov D. , Vutova C. , Koleva N. , Todorov J. , Chupetlovska K. , Penkov M. , Ananiev J. , Milenova V. , Kundurdzhiev A.
Published: October 2022

In December 2019 a newly described single-stranded coronavirus, later named SARS-CoV-2, started its expansion around the world and subsequently caused a global pandemic, affecting the lives of millions of people worldwide. SARS-CoV-2 can bind multiple receptors on different cells and thus invade many target organs, including the respiratory and gastrointestinal mucous membranes, lungs, central nervous system, heart, etc. This virus can affect the kidney tissue both directly and as a consequence of other organ involvement or of the treatment administered, causing acute kidney injury and leaving long term squeals that worsen the prognosis. We describe three patients with acute kidney injury and subsequent acute renal failure at the background of coronaviral infection.
Surgical Treatment of Infective Endocarditis, Complicated with Splenic Abscesses
Authors: Keltchev A. , Kazakov S. , Alexieva M. , Mekov E. , Yankov G.
Published: October 2022

Infectious endocarditis (IE) represents an inflammation of the heart endothelium usually as a result of bacterial colonization after trauma. Splenic abscess is a rare and dangerous extracardiac manifestation of IE. An expert multidisciplinary collaboration is necessary for the diagnosis and treatment strategy of this high-risk and challenging disease. Valvuloplasty and splenectomy are the mainstay of radical treatment and offer excellent long-term results. We present two cases with infectious endocarditis, complicated with splenic abscesses, which were successfully operated in the Department of Cardiac Surgery.
Pathophysiology and Management Possibilities of Thyroid-Associated Depression
Authors: Ivanov S. , Bakalov D. , Bocheva G.
Published: October 2022

Thyroid hormones and the hypothalamic-pituitary-thyroid (HPA) axis are responsible for multiple metabolic processes and psychological well-being. Hypothyroidism can induce mood changes, depressive symptoms and even major depressive disorder. This review is focused on the pathophysiology and mechanisms through which the low level of thyroid hormones may affect the brain function, causing the characteristic symptoms of depression. Key pathways of hypothyroid-associated depressive states include: morphological changes in some brain areas (mainly in the hippocampus – a reduction in its volume); a significant reduction of the cerebral blood flow (incl. hippocampus), and lowered levels of neurotrophic factors (e. g. BDNF – brain-derived neurotrophic factor), which are regulated by the thyroid hormones. An adequate and timely thyroid hormone replacement and treatment with conventional antidepressants often can reverse the psychological symptoms.
Estimation of Electricity Losses in Distributed Electricity Network Using an Improved Three Mode Method
Authors: Alibašić Emir , Baus Zoran , Muftić-Dedović Maja
Published: October 2022

Increasing the energy efficiency of electricity distribution networks is the commitment of all national and private electricity distribution companies. One of the basic goals is to reduce losses in electricity distribution networks. It is known that losses in the distribution network can be defined as the differences between taken and delivered electricity. Determining losses has several basic tasks. The first task is to determine the difference between the calculated losses and the actual losses, and to determine the reason for this difference and to determine the necessary guidelines for taking measures to reduce losses. The second task is to estimate the loss index for planning and formulating different plans. This paper presents a new approach to reduce the error between calculated and actual losses using a new method based on the Three Mode method. The main purpose of the study was to investigate the power losses in distribution area. The method proposed in this paper significantly reduces the error compared to the classical Three modes method, which is the original contribution of this paper.
Application of Modal and Wavelet Transformation in Detection and Localization of High Impedance Faults
Authors: Ferhatbegović Šeila Gruhonjić , Bajramović Zijad
Published: October 2022

High-resistance fault occurs when the phase comes into contact with ground or grounded parts over objects or surfaces with high resistance values. This results in small values of currents and voltages that may be insufficient for adequate operation of existing protections. As a result, the malfunction continues and can cause electric shocks, further damage to the equipment, and can be a cause of fire. Various approaches to solving this problem can be found in the literature, such as, for example, monitoring the harmonic content of currents and voltages, the application of artificial intelligence and neural networks and the application of wavelet transformation. This paper presents the results of detection and localization of high impedance fault in the distribution 10 kV network based on the application of modal and wavelet transformation of currents at the beginning of the distribution feeder.
Changing Religious Affiliations: Factors Affecting Denominational Changes In Nyambene Synod, Kenya
Authors: Mwila Bishop Alice
Published: October 2022

This paper explores the interaction between the Methodist Church in Kenya (MCK) and the neo-Pentecostal churches in the Nyambene Synod, Kenya, together with the influence of this interaction on the religious landscape. It examines changes in denominational affiliations affecting the Methodist Church, where a substantial number of (particularly young) members have moved to Pentecostal churches and movements in the region. This identifies factors affecting religious affiliation in the Nyambene Synod and the impact that changing affiliation has on the Methodist Church. Through qualitative empirical research, the study identifies three main factors that increasingly influence movements of Christians between churches: the contemporary consumer culture that emphasises personal choice, the understanding of ecclesial identity, and the relevance of the church to contemporary (Kenyan) society. The research challenges the MCK to reassess its offer within the contemporary religious marketplace, not by imitating Pentecostal churches, but by rediscovering its Wesleyan social holiness heritage.
Parallel Lives
Authors: Pritchard John
Published: October 2022

A comparative study of William Wadé Harris, 1865–1929, and Apolo Kivebulaya, 1865–1932. The Liberian Harris’s short evangelistic tour of the Ivory Coast and western Gold Coast, 1913–1915, laid the foundations of contemporary Methodism, Catholicism, and the independent Harrist Church in Côte d’Ivoire and Church of the Twelve Apostles and others in Ghana. The Ugandan Anglican priest Kivebulaya ministered in the kingdom of Toro in western Uganda, 1895–1915, and in northeast Congo, 1915–1933, and is acclaimed as the founder of the Anglican Church in the Congo.
The changing face of British Methodism between 1997 and 2008: A study in empirical theology
Authors: Haley John M. , Francis Leslie J.
Published: October 2022

This study compares the findings of two population surveys of Methodist ministers (presbyters) serving in Great Britain in 1997 and 2008. The findings identified nine areas of change: the quality of Methodist worship is improving; Methodist worship is becoming less traditional and less distinctively Wesleyan; communion is becoming less prioritised; ministers are learning to implement a better work-life balance; the work-related psychological wellbeing of minsters is improving; there is an increase in conservative religious beliefs; expectations on the practices and values of members is being relaxed; homosexual practice is becoming more acceptable; and welcome for Methodist-Anglican unity is receding.
Advances in diagnostics and management of gestational trophoblastic disease
Authors: Lukinovic Nusa , Malovrh Eva Pavla , Takac Iztok , Sobocan Monika , Knez Jure
Published: October 2022

Background

Gestational trophoblastic disease (GTD) is a heterogeneous group of rare tumours characterised by abnormal proliferation of trophoblastic tissue. It consists of benign or premalignant conditions, such as complete and partial molar pregnancy and variants of malignant diseases. The malignant tumours specifically are commonly referred to as gestational trophoblastic neoplasia (GTN). They consist of invasive mole, choriocarcinoma, placental-site trophoblastic tumour (PSTT) and epithelioid trophoblastic tumour (ETT).

Conclusions

Patients with GTD are often asymptomatic, although vaginal bleeding is a common presenting symptom. With the advances in ultrasound imaging in early pregnancy, the diagnosis of molar pregnancy is most commonly made in the first trimester of pregnancy. Sometimes, additional imaging such as chest X-ray, CT or MRI can help detect metastatic disease. Most women can be cured, and their reproductive function can be preserved. In this review, we focus on the advances in management strategies for gestational trophoblastic disease as well as possible future research directions.
Development of Mobile Learning Based Electronic Student Worksheets to Measure Learning Motivation on Sensing Systems Materials
Authors: Lafifa* Fitria , Rosana Dadan , Jumadi Jumadi , Adelia Mirsya
Published: October 2022

The material of the sensory system is important because in the sensory system there are several kinds of senses and the nervous system which is still abstract and the problem that occurs is a misconception about the material. Motivation is one of the factors that support success in learning, but students learning motivation is still low. This study aims to produce valid and feasible mobile learning-based electronic student worksheets and to measure students learning motivation on sensing system materials. The research subjects were students of class VIII MTsN 8 Banyuwangi. This study uses Research and Development methods and 4D models with 4 stages, namely define, design, develop, and dissemination. The instrument used was a material validation questionnaire, medial, readability, and students' learning motivation. The validation results show the average percentage of the material test is 94% and the media is 94% with very feasible criteria. The percentage of the students' readability test has an average value of 71% with a good category and the students' learning motivation is very strong with a percentage of 82%. Thus, electronic student worksheets can measure students' learning motivation. For future researchers, it is recommended to use the product in classroom learning
Kelayakan Media Booklet Sawi Dayak (Elephantopus mollis Kunth) pada Pembelajaran Biologi Mahasiswa
Authors: Panjaitan* Ruqiah Ganda Putri , Tenriawaru Andi Besse
Published: October 2022

Learning media can be arranged based on the results of literature studies from research on an object. This study aims to determine the feasibility of learning media booklet sawi dayak (Elephantopus mollis Kunth). The stages in this research include the stage of collecting information through a literature study on the efficacy of the mustard mustard plant, the booklet preparation stage, the booklet validation stage, and the booklet revision stage in accordance with the suggestions from the validators. Aspects that are assessed in the feasibility test are aspects of format, content, and language. The results of the validation were then analyzed using Gregory's calculations. The results of data analysis show that the aspects of format, content, and language each get a value of 1.00 and the average of these three aspects is 1.00 with a very high validity category. It is concluded that this booklet media can be used as a learning medium
Development of LKPD with a Contextual Approach Based on Flipbook to Increase Science Learning Motivation
Authors: Setianingrum* Dwi Agnes , Ula El Minahussaniyyatul , Pratiwi Septania , Jumadi Jumadi
Published: October 2022

The science learning process at SMP N 1 Pejagoan is still teacher-centered. This causes students to be less active because the control of learning is centered on the teacher, as a result, students' learning motivation decreases. To overcome this, research was carried out through the development of study guides in the form of LKPD with a contextual approach based on flipbook. This study aims to determine the feasibility level of LKPD, determine student responses, and find out whether LKPD can increase students' motivation to learn science. This study uses the Thiagarajan 4D (Four-D Model) development model, consisting of four stages, namely the definition stage, the design stage, and the development stage. The dissemination stage was not carried out, this research was only limited to product feasibility tests and limited trials. This study uses a descriptive qualitative approach. The sample in this study is class VIII A totaling 10 people. The collection technique used is a questionnaire and documentation. The results showed that: (1) LKPD with a contextual approach based on flipbook was feasible, judging from the percentage of LKPD eligibility 95.57% (very feasible), (2) student responses to LKPD were in the very good category, seen from the percentage of interest in LKPD 87.50% (very interested), and students' motivation to learn science using LKPD with a contextual approach based on flipbook was included in the high category, with a percentage of 82.81% (high motivation)
Keefektifan Model Pembelajaran Conceptual Chang Text dalam Mencegah Miskonsepsi Siswa pada Materi Larutan Penyangga
Authors: Fauzannur* Fauzannur , Hasan Muhammad , Sulastri Sulastri
Published: October 2022

The low interest in learning chemistry is because there are still some students who have different conceptions, resulting in misconceptions. This study aims to determine the level of students' misconceptions about the buffer solution material in the experimental class and control class and the effectiveness of the conceptual change text (CCT) learning model in preventing students' misconceptions about the buffer solution material at SMAN 1 Seulimeum. The method used in this study is a quasi-experimental designed with a posttest only control group design. The sample selection technique was determined with certain considerations because there were only two classes in class XI IPA, so the two classes were used as samples in this study. So the research sample taken was class XI IPA1 and XI IPA2, totaling 30 and 34 students. The instrument used is in the form of multiple-choice diagnostic test questions. The data analysis technique used four tier. The results showed that the level of students' misconceptions on the buffer solution material in the experimental class and control class before applying the learning treatment obtained an average percentage of 31.18 and 31.33. The effectiveness of the CCT learning model can prevent students' misconceptions about the buffer solution material. The results of data analysis prove that after applying the CCT model students' misconceptions decreased with the misconception score only reaching 2.65. The results of the study can be concluded that the CCT model can prevent misconceptions better than the conventional learning model through the direct instruction model
PENINGKATAN KETERAMPILAN PRESERVASI HIJAUAN PETERNAK SAPI MELALUI PENERAPAN TEKNOLOGI FERMENTASI ANAEROB
Authors: Nurmeiliasari Nurmeiliasari , Sutriyono Sutriyono , Akbarillah Tris
Published: October 2022

THE USE OF ANAEROBIC FERMENTATION TECHNOLOGY TO IMPROVE THE FORAGE PRESERVATION OF BEEF CATTLE FARMERSNurmeiliasari1*, Sutriyono 1, Tris Akbarilah 1, Nurjamiah Rangkuti2, Andre Setiawan1, Deni Hermawan1 1Jurusan Peternakan, Fakultas Pertanian, Universitas Bengkulu2 Program Studi Pengelolaan Sumber Daya Alam, Fakultas Pertanian, Universitas Bengkulu*Penulis korespondensi: sari_nurmeiliasari@unib.ac.id  (Diterima 00-00-0000; Direvisi 00-00-0000; Disetujui 00-00-0000)    Ketersediaan dan kualitas hijauan yang diberikan kepada ternak sapi yang dipelihara peternak fluktuatif dan berdampak pada produktivitas ternak. Program Pengabdian kepada Masyarakat ini bertujuan untuk mengedukasi masyarakat peternak dan memberi muatan keterampilan pembuatan silase yaitu teknologi fermentasi anaerob sederhana yang dapat diaplikasikan dengan dukungan alat sederhana untuk mengawetkan pakan. Kegiatan ini dilakukan secara luring dengan mematuhi protocol kesehatan melibatkan peternak di Kelurahan Bentiring Kota Bengkulu. Tahap pertama adalah pengenalan sumber bahan pakan hijauan, mengenai fermentasi anaerob dan praktek pembuatan silase komplit. Pembuatan silase komplit adalah dengan mencampurkan semua bahan lalu ditutup rapat di dalam plastik hitam besar dan disimpan di dalam ember dalam keadaan kedap udara. Peternak berpartisipasi aktif dalam pembuatan silase. Pemanenan dilakukan di hari ke-14 dan silase yang dihasilkan cukup baik dengan sedikit jamur yang tumbuh, warnanya hijau kekuningan dan memiliki aroma sedikit asam khas silase dan kadar air rendah. Hasil evaluasi menunjukkan bahwa peternak termotivasi untuk memanfaatkan sumber pakan dari hasil samping pertanian dan hasil praktek silase. Praktek pembuatan silase dengan bahan daun dari pelepah sawit telah dilaksanakan masyarakat dan menjadi solusi saat rumput lapang tidak tersedia. Kegiatan pengabdian masyarakat ini juga telah menghasilkan peternak yang terampil membuat silase pakan komplit dengan bahan dasar daun pelepah sawit.Kata kunci : peternak, sapi, hijauan, pelepah sawit, silase komplit
ОСОБЛИВОСТІ ОРГАНІЗАЦІЇ ДИСТАНЦІЙНОГО НАВЧАННЯ У ВОКАЛЬНО-ХОРОВІЙ ПІДГОТОВЦІ МАЙБУТНІХ УЧИТЕЛІВ МУЗИЧНОГО МИСТЕЦТВА
Authors: Пухальський Тарас , Кузів Марія
Published: October 2022

У статті розглянуто проблему організації дистанційного навчання майбутніх учителів музичного мистецтва у циклі вокально-хорових дисциплін, проаналізовано її з позиції освітніх підходів та нормативних документів. Виокремлено причини низької продуктивності дистанційних занять вокально-хорових дисциплін, які пов’язані із особливостями інформаційно-комунікаційних технологій. Запропоновано авторський підхід до розв’язання означеної проблеми, який полягає у застосуванні змішаних та комбінованих форм освітнього процесу.
ОСОБЛИВОСТІ ФОРМУВАННЯ МОРФЕМНО-СЛОВОТВІРНИХ КОМПЕТЕНЦІЙ ЗДОБУВАЧІВ ПОЧАТКОВОЇ ОСВІТИ (на прикладі ігрових технологій і технологій розвитку критичного мислення)
Authors: Чемоніна Лада
Published: October 2022

Статтю присвячено проблемі формування морфемно-словотвірних компетенцій молодших школярів. Здійснено аналіз наукових досліджень з означеної проблеми.

Висвітлено доцільність ознайомлення дітей на пропедевтичному рівні із засобами словотворення у процесі вивчення морфемної будови слова і морфології, а також особливості формування морфемно-словотвірних компетенцій через ігрові технології навчання і технології розвитку критичного мислення, подано завдання на основі різноманітних стратегій.

Стаття стане у нагоді викладачам ЗВО, учителям початкової школи та студентам.
ОРГАННА МУЗИКА У ТВОРЧОСТІ ВОЛОДИМИРА ГУБИ
Authors: Німилович Олександра
Published: October 2022

Стаття присвячена висвітленню творчості відомого українського композитора Володимира Губи (1938–2020) стосовно розкриття його багатожанрової органної спадщини. На основі музично-естетичного аналізу органного циклу “Профілі часу” осмислюється роль музики для органу у творчості митця, а також значення спадщини композитора у розвитку органного мистецтва в Україні. Сім хоральних композицій цього меморіального органного циклу В. Губи демонструють широту трактування композитором органних світових традицій у поєднанні з національним музичним матеріалом.
Visitors’ Evaluation of Destination Attributes of Penglipuran Village
Authors: Suasapha Anom Hery
Published: October 2022

Destinations attributes are important aspects of a tourist destination that will determine visitors' satisfaction. They are also essential for the DMO to understand the strengths and weaknesses of the destination, thus providing the DMO with important information to further develop the destination. Visitors' evaluation of the destination attributes of Penglipuran Village is still unknown. Therefore, his article aims to discuss the visitors’ evaluation of destination attributes of Penglipuran Village to understand attributes the visitors perceived as important and how they are performing. The research implemented a quantitative approach, using the survey as the main method to collect primary data concerning the perception of respondents toward the importance and performance of those destination’s attributes. The sample was determined purposively and chosen from a population of tourism students of Bali Tourism Polytechnic. Importance-Performance Analysis (IPA) was used to analyze the data collected from 157 respondents. The result shows that there are six attributes considered very important, with three out of those six performings impressively, while the other three are of poor performance. The result also indicates that eight attributes are considered not important, even though three of those are performing impressively, while the other five are performing poorly. Based on the result, this article recommended for the tourism management organization of Penglipuran Village to focus their attention and effort on attributes plotted on the fourth quadrant of the IPA, while providing suggestions to improve the performance of those important attributes deemed as having poor performance.

Key words: evaluation; destination attribute; importance; performance; Penglipuran.
Social Media (YouTube) Content Analysis to 5 Indonesian’s Super Priority Destination
Authors: Primastahta Candraning Koes , Widyaninggar Cakry Lientang , Mani La
Published: October 2022

The COVID-19 pandemic directly provided a huge answer to leaders. Therefore, all countries and their respective countries must have various competent policies or strategies to overcome the impact of the COVID-19 pandemic, and of course these policies or strategies are implemented and adapted to developing conditions, one of which is Virtual Tourism innovation. A tourist activity that can be enjoyed anywhere and anytime, because it only requires an internet network, social media platforms and gadgets. With the emergence of this innovation, it is hoped that it can maintain tourism and reduce the impact of the COVID-19 pandemic because it can be enjoyed at home. The purpose of the study was to determine the implementation of Government Policies in 5 Super Priority Destinations (Lake Toba, Labuan Bajo, Borobudur, Mandalika and Likupang) through social media (YouTube) with a comparative case study of promotions conducted at Wishnutama and Sandiaga's tenure. Quantitative descriptive research method using YouTube videos collected since January 1st. 2020 to February 4, 2022. The number of samples used is 65 videos that meet the requirements of 5 Super Priority Destinations. The testing tool used is Nvivo 12 Pro with several stages of Node creation to a total comparison of the subject and object of research. The result of this study is that Sandiaga is more communicative in promoting 5 Super Priority Destinations with various new programs such as video content created and consistent upload schedules. Both Wishnutama and Sandiaga have the same significant focus on the Lake Toba destination. The messages included in the uploaded YouTube videos are dominated by Communication Policy messages as well as informative messages from each destination. In addition, to support the two messages also use Advertising, Persuasive and Educational messages.

Keywords: content analysis; communication policy; 5 super priority destinations; tourism promotion; youtube.
The Strategy for Handling the Impact of Covid-19 Pandemic by Sanur Tourism Actors
Authors: Putra I Putu Angga Suta Pramana , Wiranatha Agung Suryawan , Suryawardani I Gusti Ayu Oka
Published: October 2022

The COVID-19 pandemic has given a negative impact on Sanur tourism, therefore a strategy for handling the impact of COVID-19 pandemic is needed for the restoration of Sanur tourism. This study aims to determine the strategies of tourism actors in handling the impact of COVID-19. This research uses a qualitative approach with a case study research strategy. The method used is observation, interviews, questionnaires and documentation. The theory used is perception theory to identify visitor perceptions and sustainable tourism theory to analyze the effectiveness of implementing strategies for Sanur tourism actors. The results show that the visitor's perception of the image of the Sanur destination is very good, it can be seen from the information received by visitors from Sanur tourism actors is clear, and the end understands the risks and threats when visiting so that visitors do not want to change their travel plans to Sanur. The strategies carried out by Sanur tourism actors are Reduction, Readiness, Response and Recovery. The effectiveness of implementing the strategy is seen from the environmental aspect, namely improving and rejuvenating the environment, the economic aspect of increasing tourist visits and the social aspect of growing awareness (awareness) of tourism actors and the community in the Sanur destination of the risks caused by disasters. The government and tourism actors need synergy in dealing with the impact of disasters on tourism so that they can help and speed up the handling process and minimize the negative impacts that arise.

Keywords: tourism actors strategy; covid-19; tourism crisis.
Three Afghani siblings with a novel homozygous variant and further delineation of the clinical features of METTL5 related intellectual disability syndrome
Authors: Torun Deniz , Arslan Mutluay , Çavdarlı Büşranur , Akar Hatice , Cram David Stephen
Published: October 2022

Background. METTL5 gene is one of the members of methyltransferase superfamily and biallelic variants cause intellectual disability syndrome (ID) with microcephaly. This article reports three new cases with METTL5 related ID syndrome in a consanguineous family.
Case. Afghanistan descent family was affected by a novel homozygous c.362A > G (p.Asp121Gly) METTL5 gene variant. This variant is predicted to be `pathogenic` by multiple in-silico tools. Patients had dysmorphic and neurodevelopmental features including intellectual disability, microcephaly, poor/absent speech, delayed walking, aggressive behavior, large/posteriorly rotated ears, broad nasal base and short stature, which seem to be the cardinal findings of the designated syndrome.
Conclusions. While the data reported in these individuals indicate characteristic clinical features of METTL5 related ID syndrome, further investigations and study of additional cases are needed to improve the understanding of disease pathogenesis, and management.
Hyperprolactinemia in children and adolescents and longterm follow-up results of prolactinoma cases: a single-centre experience
Authors: Kontbay Tuğba , Şıklar Zeynep , Özsu Elif , Uyanık Rukiye , Bilici Esra , Ceran Ayşegül , Berberoğlu Merih
Published: October 2022

Background. Hyperprolactinaemia refers to increased circulating prolactin and is divided into functional and pathological hyperprolactinaemia. Prolactinoma is the most common cause of severe hyperprolactinaemia. Prolactinomas are rare in children. Treatment outcomes and long-term follow-up data in children are insufficient. Dopamine agonists are the first step in the treatment of prolactinomas. There are no recommendations supported by a high level of evidence regarding the dose and duration of cabergoline treatment.
Methods. Patients with hyperprolactinaemia were evaluated for etiological, clinical, and follow-up characteristics. The case files of patients with high prolactin levels who were followed up in our clinic between 2001 and 2019 were reviewed retrospectively.
Results. 27 cases (20 female, 7 male) with hyperprolactinemia were detected. The median age of the cases was 15 years (0.3-17.4). Prolactinoma was detected in 40.7% of the cases (n=11). Among these cases, six were macroadenomas. The median prolactin level was 118 ng/mL (34-4340) in those with prolactinoma and 60 ng/mL (22-200) in the hyperprolactinaemia group (p=0.007). In the prolactinoma group, the median age at presentation in macroadenoma cases (13.8 years) was lower than in microadenoma cases (17 years) (p=0.06). There was a negative correlation between prolactin level and height SDS (r=-0.770, p=0.06). In all cases, the median initial cabergoline dose was 0.5 mg/week, and prolactin levels returned to normal within an average of 2.6±2.4 months. Cabergoline treatment achieved a 50% reduction in adenoma size in the first year of treatment without high doses.
Conclusions. Prolactinoma consists of an important group among hyperplolactinemia in children. In our study, prolactinoma was detected in 40.7% of children with hyperplolactinemia, and children with prolonged use (over 4 years) tolerated cabergoline well and prolactin levels normalized without high doses. Follow-up is required for relapse after discontinuing the treatment.
Clinical course of primary empty sella in children: a singlecenter experience
Authors: Besci Özge , Yaşar Elif , Erbaş İbrahim Mert , Acınıklı Kübra Yüksek , Demir Korcan , Böber Ece , Abacı Ayhan
Published: October 2022

Background. Various studies, mainly conducted in adults, have examined the hormonal axis in primary empty sella (PES), and reported various forms of pituitary deficiencies. We report our experience with PES in pediatric patients in terms of pituitary function, associated impairments, and responses to treatment.
Methods. We reviewed 10,560 cranial and 325 pituitary magnetic resonance imagings (MRIs) performed at our university hospital between January 2010 and December 2020 and identified patients with PES. Patients with additional abnormal MRI findings, a history of cranial surgery or radiotherapy, autoimmunity, long-term use of chemotherapeutic or immunosuppressive agents or incomplete diagnostic evaluation were excluded. Clinical, radiological and laboratory evaluations were recorded.
Results. The study included 17 patients [9 girls, 8 boys; median age 12.4 years (7.25, 4.3 - 17)]. The median size of the pituitary was 2 mm (0.7, 1.2 - 3). Based on age-dependent pituitary height measurements, fifteen (88%) patients had pituitary gland hypoplasia. Five patients presented with short stature, two had both pubertal delay and short stature, and one had pubertal delay. Nine patients presented with neurological symptoms such as headaches, tinnitus, tics, and dizziness. Five short patients had growth hormone deficiency. None of the patients had hyper- or hypoprolactinemia, adrenal insufficiency, hypothyroidism, or diabetes insipidus. There was statistically no significant association between the size of the pituitary gland and the severity of hypopituitarism (p = 0.42).
Conclusions. The high incidence of pituitary dysfunctions ascertain that this entity should not be considered a normal variant but, should instead be carefully evaluated with appropriate basal and dynamic hormonal testing.
A unique case of a newborn with a hemangioma on the omphalocele sac
Authors: Erten Elif Emel , Azılı Müjdem Nur , Güney Doğuş , Demir Sabri , Ertürk Ahmet , Öcal Medine Ezgi , Demir Tuğba Örnek , Bostancı Süleyman Arif , Öztorun Can İhsan , Şenel Emrah
Published: October 2022

Background. Mass lesions of the umbilical cord are rare anomalies. There have been rare reports of hemangiomas of the umbilical cord, but the co-occurrence of omphalocele and hemangioma of the umbilical cord has not been previously reported. Nonetheless, the condition is clinically significant as it may cause the disturbance of intrauterine fetal circulation, retardation of fetal growth and development, non-immune hydrops fetalis, morbidity and mortality.
Case. Here we aim to report a case that was prenatally diagnosed with an omphalocele and that presented after birth with a hemangioma on the omphalocele sac.
Conclusions. When dealing with umbilical mass lesions in the prenatal and postnatal periods, a hemangioma on the omphalocele sac should be considered in the differential diagnosis of patients when an omphalocele is suspected.
Decreased antioxidant capacity with serum native thiol and total thiol levels in children with hemophilia A: a prospective case-control study
Authors: Taşar Serçin , Güven Ayşe Gül , Olgaç Asburçe , Neşelioğlu Salim , Erel Özcan , Alioğlu Bülent
Published: October 2022

Background. Experimental studies have addressed the role of oxidant stress in the pathogenesis of Hemophilia A. This study aimed to determine whether dynamic thiol-disulfide exchange, a recently recognized cellular defense system against oxidative stress, is disturbed in children with hemophilia A.
Methods. This prospective case control study included male children with hemophilia A (n=62) and randomly selected healthy age and sex-matched controls (n=62). Serum native thiol, total thiol and disulfide levels were analyzed with a novel spectrophotometric method. Ratios of disulfide/total thiol, disulfide/native thiol, and native/total thiol were calculated. Statistical comparisons were made using the independent samples t-test or the Mann-Whitney U test, according to whether the data were normally distributed or not.
Results. Serum native thiol (385.0 ± 35.9 versus 418.0 ± 44.3, respectively; p < 0.001) and total thiol (424.2 ± 38.7 versus 458.0 ± 46.3, respectively; p > 0.001) levels were significantly lower in children with Hemophilia A compared to controls. Children with hemophilia A had significantly lower serum native thiol to total thiol ratio than controls (p=0.024). Serum disulfide levels of children with hemophilia A were close to controls (19.2 [17.6- 22.1] versus 19.8 [17.8- 21.2]), respectively; p=0.879) whereas disulfide to native thiol ratio (p=0.024) and disulfide to total thiol ratio (p=0.024) were significantly higher.
Conclusions. Decreased antioxidant capacity with levels of serum native thiol and total thiol in children with hemophilia A might be regarded as evidence for the disturbance of thiol/disulfide balance. Antioxidant treatment can be a future target of therapy in children with hemophilia A.
A Review on Chemical and Physical Methods of Controlling Microbial Growth
Authors:   Bonga University, Choramo Alemayehu
Published: October 2022

Microorganisms are ubiquitous and many microbes are associated with harmful consequences, like food spoilage and disease
Evaluation of the use of a manual to support a large-scale implementation of the “Estratégia amamenta e alimenta Brazil”
Authors:   Secretaria De Estado De Saude De Mato Grosso, Barbosa Relvas Glaubia Rocha
Published: October 2022

To evaluate the implementation of the Tutor Support Manual of Estratégia Amamenta e Alimenta Brasil (EAAB) – the "Manual", developed to support Continuing Education Activities (CEA) in primary health care
Chemical and Consumer Acceptance of Soymilk Enriched Rice Based Masa
Authors:   Federal University Gashua, AF Ogori
Published: October 2022

Chemical and Consumer Acceptance of Soymilk enriched rice-based masa was investigated. The source rice for this was cleaned
Residual Allergenicity Assessment of Cow’s Milk Hydrolysates
Authors:   Danone Nutricia Research, Knipping Karen
Published: October 2022

Hypoallergenic extensively hydrolyzed cow’s milk formulas can be used as an alternative diet for infants who have mild to moderate cow’s milk allergy in case breast-feeding is not possible
Ensino híbrido na educação de surdos durante a pandemia: desafios da formação
Authors: Pinheiro Andrea Pestana , Sena Lílian de Sousa , Serra Ilka Márcia Ribeiro de Souza
Published: October 2022

O ano de 2020 foi muito importante para (re)pensar a educação no Brasil, por ser aquele em que a comunidade educacional precisou se ressignificar perante os novos desafios impostos pela pandemia da Covid-19, necessitando de formações para a capacitação dos docentes na chamada “nova” modalidade de ensino. Nesse sentido, este trabalhotem por objetivo fazer um recorte sobre o que aconteceu e vem acontecendo no meio acadêmico após ser decretada a pandemia. A pesquisa em comento investiga, sob o viés da análise qualitativa, utilizando-se de questionários, as principais dificuldades encontradas pelos docentes de salas inclusivas do ensino médio e profissionais de salasde recursos multifuncionais, no processo da aprendizagem de estudantes surdos, com o uso das tecnologias, e a real necessidade de formação desses docentes frente ao ensino híbrido. Tem como bases teóricas norteando este constructo textual: Giroto (2012), Moran (2015), Moreira (2020) e Quadros (2003). Os resultados apontam esforços no contexto do ensino de estudantes surdos, visto que as mudanças de paradigmas educacionais ressignificaram e estão ressignificando os agentes, os modos/meios, os instrumentos e as finalidades educacionais, além de apontarem necessidades de inovações das práticas educativas.
PENGARUH KEPEMILIKAN MAYORITAS, PROFITABILITAS, UKURAN PERUSAHAAN, DAN UMUR PERUSAHAAN TERHADAP PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY (PERUSAHAAN YANG MEMENANGKAN CORPORATE SOCIAL RESPONSIBILITY AWARDS (ICSRA) 2021)
Authors: La Viola Caroline , Mayangsari Sekar
Published: October 2022

This study aims to determine majority ownership, profitability, company size, and company age on the disclosure of Corporate Social Responsibility in publicly listed companies on the Stock Exchange for the 2018-2021 period and win the 2021 Corporate Social Responsibility Awards (ICSRA). This study used a sample of 20 company premises purposive sampling techniques. The data analysis technique used is the Classical Assumption Test, namely the Error Normality Test, Autocorrelation Test, Multicollinearity Test, and Heteroscedasticity Test, and continued with the Theory Test, namely the Coefficient of Determination Test, F Statistics Test, and T Statistical Test. The results of this study partially show that Majority Ownership and Profitability have a significant effect on the disclosure of Corporate Social Responsibility disclosures, besides Company Size has no significant effect on Corporate Social Responsibility Disclosure and Company Size does not have a significant negative effect on Corporate Social Responsibility disclosure. In addition, the results of this study simultaneously majority ownership, profitability, company size, and company age have a significant effect on the disclosure of Corporate Social Responsibility.
PERNGARUH PENERAPAN EXTENSIBLE BUSINESS REPORTING LANGUAGE (XBRL) TERHADAP ASIMETRI INFORMASI PADA PERUSAHAAN YANG TERDAFTAR DI INDEKS IDX30 PADA BURSA EFEK INDONESIA PERIODE 2013-2018
Authors: Naomi Celine , Aryati Titik
Published: October 2022

Asimetri informasi merupakan ketidakseimbangan informasiyang didapat oleh agen dan investor. Adanya transparansiinformasi sangat dibutuhkan di pasar modal. Extensible Business Reporting Language (XBRL) merupakan format standarpelaporan keuangan baru yang telah di terapkan berbagaiNegara dengan tujuan untuk meningkatkan kualitas laporankeuangan emiten di pasar modal agar informasi dapat lebihtransparan dan efisien. Penelitian ini bertujuan untukmengetahui pengaruh penerapan sistem pelaporan keuanganberbasis Extensible Business Reporting Language (XBRL) terhadap asimetri informasi. Penelitian ini menggunakan metodekuantitatif. Populasi dari penelitian ini merupakan perusahaanyang telah terdaftar di indeks IDX30 pada Bursa Efek Indonesia selama periode 2013-2018. Pemilihan sampel dilakukan denganmenggunakan metode purposive sampling. Jumlah sampel yang diolah sebanyak 60 sampel yang terdiri dari 15 perusahaantercatat. Teknik pengumpulan data dilakukan dengan metodedokumentasi yang diambil di situs Bursa Efek Indonesia. Data diolah dengan menggunakan paired samples test denganmenggunakan program SPSS25. Hasil penelitian menunjukkanpenggunaan XBRL dapat memperkecil terjadinya asimetriinformasi.