bluuebunny/crossref_metadata_2025 huggingface dataset:
PD-1, PD-L1 and PD-L2 Expression in Mantle Cell Lymphoma and Healthy Population
Authors: Karolova J. , Radek M. , Helman K. , Spacek M. , Trneny M. , Klener Pavel
Published: August 2023

Cell surface expression of PD-1, PD-L1 and PD-L2 immune checkpoints on B and T cells obtained from patients with mantle cell lymphoma shows ambiguous results across many studies and creates obstacles for the implementation of immune checkpoint inhibitors into the therapy of mantle cell lymphoma. Using multiparameter flow cytometry we analysed surface expression of PD-1, PD-L1 and PD-L2 molecules on B and T cells of 31 newly diagnosed mantle cell lymphomas and compared it with the results of 26 newly diagnosed chronic lymphocytic leukaemias and 20 healthy volunteers. To gain insight into the age-dependent changes of surface expression of these immune checkpoints, flow cytometric subanalysis of 30 healthy volunteers of 25–93 years of age was conducted. Overall, we demonstrated weak surface expression of PD-1, PD-L1 and PD-L2 on B and T cells of mantle cell lymphoma patients (< 10 % when compared to healthy individuals). A significant age-dependent increase in the expression of PD-1 and its ligand PD-L2 was observed in healthy volunteers. Our results suggest that neither PD-1 nor its ligands represent relevant druggable targets for the therapy of mantle cell lymphoma. The observed age-dependent changes in healthy population could impact efficiency of immune checkpoint inhibitors and could be at least partly connected with increased incidence of cancer with age.
Phenotype Variability in Czech Patients Carrying PAX6 Disease-Causing Variants
Authors: Moravikova J. , Kozmik Z. , Hlavata L. , Putzova M. , Skalicka P. , Michaelides M. , Malinka F. , Dudakova Lubica , Liskova P.
Published: August 2023

The aim of this study was to report PAX6 disease-causing variants in six Czech families, to describe the associated phenotypes, and to perform functional assessment of the splice site variants. Detailed ophthalmic examination was performed. The PAX6 coding region was directly sequenced in three probands. Two probands were analysed by exome sequencing and one by genome sequencing. The effect of two variants on pre-mRNA splicing was evaluated using an exon trapping assay. Six different heterozygous PAX6 variants were identified, with c.111_120del and c.1183+1G>T being novel. Both c.1183+1G>T and c.1032+1G>A were proved to cause aberrant splicing with exon skipping and subsequent frameshift. The phenotypic features were variable between and within families. One individual, aged 31 years, presented with mild unilateral ptosis accompanied by aniridia in the right eye, partial aniridia in the left eye, and bilateral congenital cataracts, without marked foveal hypoplasia. Bilateral microcornea, partial aniridia, congenital cataracts, and a large posterior segment coloboma were found in another proband, aged 32 years. One child, aged 8 years, had bilateral high myopia, optic nerve colobomas, anterior polar cataracts, but no iris defects. Another individual, aged 46 years, had bilateral congenital ptosis, iris hypoplasia, keratopathy with marked fibrovascular pannus, anterior polar cataract, and foveal hypoplasia combined with impaired glucose tolerance. However, his daughter, aged 11 years, showed classical features of aniridia. Our study extends the genetic spectrum of PAX6 disease-causing variants and confirms that the associated phenotypic features may be very broad and different to the ‘classical’ aniridia.
Genistein Induces Bcl-2 Expression in Human Dermal Microvascular Endothelial Cells: a Short Report
Authors: Lachová V. , Mitrengová P. , Melegová N. , Smetana K. , Gál Peter
Published: August 2023

It has been shown previously that oestradiol protects the vascular network, leading to increased skin flap viability associated with Bcl-2, VEGF and FGF-2 up-regulation. We have shown that genistein, a natural selective oestrogen receptor modulator, also increases skin flap viability in rats and induces Bcl-2 expression in human umbilical vein endothelial cells. In the present study we aimed to answer the question whether genistein increases expression of Bcl-2, a potent anti-apoptotic protein, in human dermal microvascular endothelial cells (HMVEC-d) as well. Our results showed that administration of genistein induces Bcl-2 expression in a concentration-dependent manner. Cell co-treatment with genistein and anti-ER compounds (MPP, PHTPP, ICI, G-15) diminished the observed positive effect of genistein on Bcl-2 expression. The decrease in Bcl-2 expression in HMVEC-d was most prominent after co-treatment with ICI (nuclear ER antagonist/ GPR30 agonist) and PHTPP (selective ER-β antagonist). In conclusion, genistein increases Bcl-2 expression in HMVEC-d, contributing to its protective effect on the skin flap viability. However, the question whether the mechanism is ER-specific (via ER-β) has to be answered in further studies using a model of gene silencing or genetically modified cells.
Genetic Markers at ANRIL, FTO and 2q36.3 Locus in Czech Patients Undergoing Coronary Artery Bypass Graft Surgery
Authors: Kačer Petr , Pirk J. , Lánská V. , Hubáček J. A. , Adámek V. , Červinková T. , Bělohoubek J. , Auzký O. , Adámková V.
Published: August 2023

Coronary artery bypass graft (CABG) surgery is one of the most commonly performed operations worldwide. We compared genotype frequencies of three major cardiovascular disease (CVD)-associated genetic markers (ANRIL,FTOand2q36.3locus) between 753 patients who underwent CABG at the Institute for Clinical and Experimental Medicine (Prague, Czech Republic) and 2,559 controls from the Czech post-MONICA study. Subjects with at least one major A allele in the rs10757274 polymorphism (ANRIL) were more prevalent in patients after CABG than in the controls (81.7 % vs 72.7 %; OR [95 % CI] 1.67 [1.35-2.05]; P < 0.0001). In contrast, variants within theFTOgene (OR 0.87; 95% CI, 0.70-1. 09 in a TT vs. GG comparison, P = 0.24) and2q36.3locus (OR 1.16; 95% CI, 0.98-1.37 in a +A vs. CC comparison, P = 0.08) were not significantly associated with CVD in our study. Variants were not associated with anthropometric, biochemical, or clinical characteristics within the patient group. Our study suggests that patients with CABG are more commonly carriers of some but not all CVD-associated alleles.
Interdiffusion between 316L Stainless Steel and Copper in Coatings Processed by High Velocity Oxyfuel
Authors: Cruz Juliane Ribeiro da , Colombes Andressa , d’Oliveira Ana Sofia C. M.
Published: August 2023

Joining of stainless steel and copper is of interest to a variety of applications that range from heat exchanger to nuclear waste container. Nevertheless, welding of these dissimilar metals is challenging because of the risk of hot cracks and lack of fusion associated with their differences in melting temperatures and thermal conductivities. In this work, joining of 316L stainless steel and copper by high velocity oxyfuel is investigated using two systems of materials, the first consisting of copper coatings on AISI 316 substrates, and the second of 316L coatings on copper substrates. To promote metallurgical bonding, the systems were exposed to 500°C, 700°C, 900°C, and 950°C for 10 h under flowing argon atmosphere. Microstructure was characterized by optical and scanning electron microscopy and energy-dispersive x-ray spectroscopy. Bending tests were carried out to qualitatively investigate the coatings adhesion and cohesion strength. It was found that 316L coatings have a much superior adhesion to copper substrates than copper coatings had to AISI 316 substrates, associated with the ease of 316L incoming particles to embed in the softer copper matrix and with the higher susceptibility of 316L coatings to diffuse into copper substrates. In contrast, in copper coatings, copper oxides formed during deposition decomposed during heat treatment, releasing oxygen that caused porosity and oxidation on the interface with the stainless-steel substrate, preventing the formation of a clean metallurgical bond. Diffusion of iron-rich oxide inward the copper coating was also observed near the interface, indicating that diffusion of steel into copper is more likely than diffusion of copper into steel. Nevertheless, heat exposure was found to increase damage tolerance of copper coatings, associated with a higher coating ductility and compliance.
Automated Segmentation of the Mouse Body Language to Study Stimulus-Evoked Emotional Behaviors
Authors: Chelini Gabriele , Trombetta Enrico Maria , Fortunato-Asquini Tommaso , Ollari Ottavia , Pecchia Tommaso , Bozzi Yuri
Published: August 2023

Understanding the neural basis of emotions is a critical step to uncover the biological substrates of neuropsychiatric disorders. To study this aspect in freely behaving mice, neuroscientists have relied on the observation of ethologically relevant bodily cues to infer the affective content of the subject, both in neutral conditions or in response to a stimulus. The best example of that is the widespread assessment of freezing in experiments testing both conditioned and unconditioned fear responses. While robust and powerful, these approaches come at a cost: they are usually confined within selected time windows, accounting for only a limited portion of the complexity of emotional fluctuation. Moreover, they often rely on visual inspection and subjective judgment, resulting in inconsistency across experiments and questionable result interpretations. To overcome these limitations, novel tools are arising, fostering a new avenue in the study of the mouse naturalistic behavior. In this work we developed a computational tool [stimulus-evoked behavioral tracking in 3D for rodents (SEB3R)] to automate and standardize an ethologically driven observation of freely moving mice. Using a combination of machine learning-based behavioral tracking and unsupervised cluster analysis, we identified statistically meaningful postures that could be used for empirical inference on a subsecond scale. We validated the efficacy of this tool in a stimulus-driven test, the whisker nuisance (WN) task, where mice are challenged with a prolonged and invasive whisker stimulation, showing that identified postures can be reliably used as a proxy for stimulus-driven fearful and explorative behaviors.
Cholinergic Reinforcement Signaling Is Impaired by Amyloidosis Prior to Its Synaptic Loss
Authors: Allard Simon , Hussain Shuler Marshall G.
Published: August 2023

Alzheimer's disease (AD) is associated with amyloidosis and dysfunction of the cholinergic system, which is crucial for learning and memory. However, the nature of acetylcholine signaling within regions of cholinergic-dependent plasticity and how it changes with experience is poorly understood, much less the impact of amyloidosis on this signaling. Therefore, we optically measure the release profile of acetylcholine to unexpected, predicted, and predictive events in visual cortex (VC)—a site of known cholinergic-dependent plasticity—in a preclinical mouse model of AD that develops amyloidosis. We find that acetylcholine exhibits reinforcement signaling qualities, reporting behaviorally relevant outcomes and displaying release profiles to predictive and predicted events that change as a consequence of experience. We identify three stages of amyloidosis occurring before the degeneration of cholinergic synapses within VC and observe that cholinergic responses in amyloid-bearing mice become impaired over these stages, diverging progressively from age- and sex-matched littermate controls. In particular, amyloidosis degrades the signaling of unexpected rewards and punishments, and attenuates the experience-dependent (1) increase of cholinergic responses to outcome predictive visual cues, and (2) decrease of cholinergic responses to predicted outcomes. Hyperactive spontaneous acetylcholine release occurring transiently at the onset of impaired cholinergic signaling is also observed, further implicating disrupted cholinergic activity as an early functional biomarker in AD. Our findings suggest that acetylcholine acts as a reinforcement signal that is impaired by amyloidosis before pathologic degeneration of the cholinergic system, providing a deeper understanding of the effects of amyloidosis on acetylcholine signaling and informing future interventions for AD.

SIGNIFICANCE STATEMENTThe cholinergic system is especially vulnerable to the neurotoxic effects of amyloidosis, a hallmark of Alzheimer's disease (AD). Though amyloid-induced cholinergic synaptic loss is thought in part to account for learning and memory impairments in AD, little is known regarding how amyloid impacts signaling of the cholinergic system before its anatomic degeneration. Optical measurement of acetylcholine (ACh) release in a mouse model of AD that develops amyloidosis reveals that ACh signals reinforcement and outcome prediction that is disrupted by amyloidosis before cholinergic degeneration. These observations have important scientific and clinical implications: they implicate ACh signaling as an early functional biomarker, provide a deeper understanding of the action of acetylcholine, and inform on when and how intervention may best ameliorate cognitive decline in AD.
Mobile Hollywood: Labor and the Geography of Production
Authors: Sanson Kevin
Published: August 2023

Contemporary film and television production is extraordinarily mobile. Filming large-scale studio productions in Atlanta, Budapest, London, Prague, or Australia’s Gold Coast makes Hollywood jobs available to people and places far removed from Southern California—but it also requires individuals to uproot their lives as they travel around the world in pursuit of work. Drawing on interviews with a global contingent of film and television workers, Kevin Sanson weaves an analysis of the sheer scale and complexity of mobile production into a compelling account of the impact that mobility has had on job functions, working conditions, and personal lives. Mobile Hollywood captures how an expanded geography of production not only intensifies the often-invisible pressures that production workers now face but also stretches the parameters of screen-media labor far beyond craftwork and creativity.
Directions for improving the organization of the process of strategizing the development of industrial enterprises in Ukraine in the context of decentralization
Authors:   Odessa Polytechnic State University, Niekrasova Liubov , Butkovska Valentyna ,   Odessa Polytechnic State University
Published: August 2023

The article substantiates a conceptual approach to the strategizing of industrial enterprises in the context of decentralization, which consolidates the resources of industrial enterprises and a united territorial society on the basis of common interests and goals of sustainable development, which contributes to the formation of social partnership relations between society, local authorities and business. A cascade coordination of the actions of a production enterprise and local governments in the field of development strategy is proposed, which consists in cascading sustainable development goals and building interconnected strategic maps of the "united territorial community - production enterprise" system, which increases the consistency of key sustainable development priorities, goals of industrial enterprises and social tasks -economic development of the united territorial society, determines the procedure for the formation and implementation of strategies, indicators of their effectiveness and efficiency.
CRM-system as the basis of formation of consumer loyalty
Authors:   Vinnytsia Institute of Trade and Economics of KNUTE, Polishchuk Iryna
Published: August 2023

The article is devoted to the topic of application of customer relationship management system as one of the main elements of increasing consumer loyalty. The article discusses in detail the algorithms and key points of implementation of CRM-system, its advantages and disadvantages. Possibilities of automation of business processes by means of this system are defined. The reasons that require the introduction and use of CRM are considered
Cost optimization as an element of the mechanism for ensuring the financial stability of the enterprise
Authors:   Odessa Polytechnic State University, Yanovskyi Danylo
Published: August 2023

Financial stability is a reflection of a stable excess of income over expenses, ensures the availability of funds at the enterprise. Through effective use - contributes to the smooth process of production and sales of products. This article discusses and analyzes the current methods of classification and cost optimization. The main types of costs are described. The place of expenses in the system of indicators has been identified, consistently forming the break-even and financial stability of the enterprise.
Modern Information Technologies of Business Planning Enterprises Innovative Activities
Authors:   Odessa Polytechnic State University, Kovtunenko Yurii , Tkachenko Marina ,   Odessa State Agrarian University, Fedosyuk Veronika ,   Odessa Polytechnic State University
Published: August 2023

In this article the planning urgency in modern conditions of enterprises innovative activities development is investigated and generalized and the world and domestic methods and standards of drawing up of a business plan are analyzed.The advantages, positive consequences and disadvantages of implementing the automation are highlighted and analyzed. Substantiation and coverage of issues related to the automation of management systems and software for planning marketing and advertising. A comparative description of special software products functionality that allow to visually interpret the data, make up the financial part of the project, contain tools for analytical analysis, allow you to combine several projects.
Improving emotional and psychosexual well-being screening in women living with polycystic ovary syndrome: experiences from the United Kingdom and India
Authors: Hebbar Meghnaa , Khalil Halimah , Zia Nawal , Sheikh Jameela , Melson Eka , Davitadze Meri , Gleeson Helena , Lathia Tejal , Selvan Chitra , Kempegowda Punith , _ _
Published: August 2023

With increasing evidence of emotional well-being disorders associated with polycystic ovary syndrome (PCOS), effective screening processes are of utmost importance. We studied the impact of using questionnaires to screen for emotional and psychosexual well-being across different models of care for PCOS. We analysed the data from the surveys to assess the difference in the prevalence of emotional and psychosexual ill-being across ethnicity and region. In this prospective cohort study, we invited all women attending consultations for PCOS in Birmingham, UK, and Bengaluru and Navi Mumbai, India. Those who consented to participate in the study were invited to complete a pre-clinic survey about socio-demographic data, Hospital Anxiety and Depression Scale (HADS), Body Image Concern Inventory (BICI), Beliefs about Obese Person scale (BAOP), and Female Sexual Function Index score (FSFI) and a post-clinic survey on clinic experience, lifestyle advice, and specialist referral. A total of 115 women were included in this study. The rate of questionnaire completion was 98.3% (113/115), 97.4% (112/115), 93.04% (107/115), and 84.3% (97/115) for HADS, BICI, BAOP, and FSFI, respectively. In the post-clinic survey, 28.8% reported they were screened for anxiety, 27.1% for depression, and 45.8% for body image concerns. The prevalence of anxiety, depression, and body dysmorphic disorder through pre-clinic survey was 56.5% (50.0% UK vs 59.5% India, P = 0.483), 16.5% (13.9% UK vs 17.7% India, P = 0.529), and 29.6% (36.1% UK vs 26.6% India, P = 0.208), respectively. Surveys with validated questionnaires can improve screening for emotional and psychosexual well-being associated with PCOS which may be missed by ad hoc screening during consultations.
Peptides disrupting TM4SF3 interaction with AR or AR-V7 block prostate cancer cell proliferation
Authors: Khatiwada Prabesh , Rimal Ujjwal , Malla Mamata , Han Zhengyang , Shemshedini Lirim
Published: August 2023

Androgen receptor (AR) plays a vital role in the development and progression of prostate cancer from the primary stage to the usually lethal stage known as castration-resistant prostate cancer (CRPC). Constitutively active AR splice variants (AR-Vs) lacking the ligand-binding domain are partially responsible for the abnormal activation of AR and may be involved in resistance to AR-targeting drugs occurring in CRPC. There is increasing consensus on the potential of drugs targeting protein–protein interactions. Our lab has recently identified transmembrane 4 superfamily 3 (TM4SF3) as a critical interacting partner for AR and AR-V7 and mapped the minimal interaction regions. Thus, we hypothesized that these interaction domains can be used to design peptides that can disrupt the AR/TM4SF3 interaction and kill prostate cancer cells. Peptides TA1 and AT1 were designed based on the TM3SF3 or AR interaction domain, respectively. TA1 or AT1 was able to decrease AR/TM4SF3 protein interaction and protein stability. Peptide TA1 reduced the recruitment of AR and TM4SF3 to promoters of androgen-regulated genes and subsequent activation of these AR target genes. Peptides TA1 and AT1 were strongly cytotoxic to prostate cancer cells that express AR and/or AR-V7. Peptide TA1 inhibited the growth and induced apoptosis of both enzalutamide-sensitive and importantly enzalutamide-resistant prostate cancer cells. TA1 also blocked the migration and malignant transformation of prostate cancer cells. Our data clearly demonstrate that using peptides to target the important interaction AR has with TM4SF3 provides a novel method to kill enzalutamide-resistant prostate cancer cells that can potentially lead to new more effective therapy for CRPC.
The Current State and Characteristics of Parental Educational Anxiety and Contributing Factors
Authors: Ding Yadong , Xue Haiping
Published: August 2023

The study focused on the parents of compulsory education students in Shanghai city. Through a large-scale survey and subsequent data analysis, it aimed to the status quo and characteristics of educational anxiety among parents of compulsory education students; analyze the factors in parental educational anxiety from the standpoints of educational policies, schools, families, and students; and propose recommendations on improving the education policy system from the perspective of policy design.
Effect of Sesbania and Triticale rotation on plant characteristics and soil quality in coastal saline-alkaline land: A two-year field experiment
Authors: Yu Chunxiao , Wang Guangmei , Liu Xiaoling , Zhang Haibo , Ma Qian , Liu Hanwen , Zhang Yi , Li Hongxiu
Published: August 2023

Soil salinization and nutrient deficiency limit agricultural production in the Yellow River Delta region. This study investigates the green manure-forage grass rotation on soil quality and productivity. A two-year field experiment was conducted to investigate the effects of different varieties of Sesbania cannabina and ᵡTriticosecale Wittm rotations on soil properties, biological characteristics, and adaptability in coastal saline-alkali land. Four cropping rotation systems were set: Gaoyuan 2 – Lujing 2 (G2L2), Gaoyuan 2 – Lujing 5 (G2L5), Gaoyuan 1640 – Lujing 2 (G1640L2), and Gaoyuan 1640 – Lujing 5 (G1640L5). The G2L5 rotation demonstrated superior enhancement of soil quality. The soil organic matter increased by 35.8%, and the soil electric conductivity (CEC) increased by 20.2%. Compared with T. Wittm, S. cannabina had a significant positive effect on soil physical and chemical properties. S. cannabina L5 showed improved performance in mass density, fresh weight of stem, leaf and aboveground part, etc. After S. cannabina returned to the field, T. Wittm G2 had greater plant height, thousand-grain weight, and stem weight, and the yield reached 322 kg per 667 m2. In conclusion, G2L5 is the recommended planting model in saline-alkali soil. This research offers valuable insight for the efficient planting and sustainable development of coastal saline-alkali land.
Does Higher Oil Prices Influence Renewable Energy Consumption? A Cross-sectional Approach
Authors: Farouq Ibrahim , Sulong Zunaidah
Published: August 2023

One of the most effective strategies to mitigate global warming is to reduce the use of fossil fuels in the generation of energy. Thus, transitioning to renewable energy is critical to long-term sustainable growth. One of the Sustainable Development Goals of United Nations is to transition towards renewable energy. But many resource-rich economies are faced with numerous barriers towards the transformation process. In this regard, we examine the effect of increased oil prices, income, information communication technology, and financial development on renewable energy consumption in some OPEC member nations from 1980 to 2020. The findings shows that oil price has a negative effect on renewable energy consumption. While information communication technology moderates the relationship between financial development and renewable energy consumption. Therefore, A green finance system helps a country to build an ecologically sound renewable energy system, which greatly stimulates the usage of renewable energy. Green financial institutions should be formed in all sample nations to encourage financial activity and support environmentally beneficial projects.
The Art of Nanoimmunoherbogenomics 5.0
Authors: Anurogo Dito
Published: August 2023

Nanoimmunoherbogenomics 5.0 symbolizes an innovative convergence of nanotechnology, immunology, genomics, and herbal medicine, enabling precision-guided immunomodulation, targeted drug delivery, and personalized therapeutic approaches. It leverages nanotechnology's accuracy, the immune system's versatility, the profundity of genomic data, and herbal medicine's therapeutic properties to combat complex diseases like cancer and autoimmune disorders more effectively, while also minimizing side effects. By integrating herbogenomics, treatments can be customized to accommodate each individual's unique genetic and physiological profiles, paving the way for a revolution in personalized medicine. However, the rise of this groundbreaking field calls for corresponding advancements in policy and regulation, emphasizing safety, efficacy, ethics, and transparency. An interdisciplinary advisory panel could guide the formulation of these regulations, ensuring a responsible application of the science. This emerging discipline, therefore, holds the potential for a significant paradigm shift towards a more holistic, individualized, and precise approach to healthcare.
ЗЕРНОВИЙ ЕКСПОРТ УКРАЇНИ В УМОВАХ ВІЙНИ
Authors: ОСТАШКО Тамара
Published: August 2023

Досліджено шляхи і проблеми зернового експорту України в умовах війни. Основними шляхами відновлення експорту зерна є «смуги солідарності» Україна – ЄС і Чорноморська зернова ініціатива. Проте ці заходи лише частково вирішили проблему експорту зерна з України у 2022 – на початку 2023 р. У 2022 р. відбулося зменшення обсягів експорту українського зерна на 32,6 % порівняно з обсягами попереднього року. Повномасштабна воєнна агресія РФ проти України спричинила різке зростання світових цін на пшеницю, а започаткування «смуг солідарності» й морського зернового коридору посприяли їх суттєвому зниженню, зокрема на зерно. Проте вітчизняні виробники зерна і експортери не змогли скористатися зростанням світових цін на зерно у 2022 р. через збільшення транспортних видатків при перевезенні до портів, зростання маржі посередників з урахуванням ризиків воєнного часу, підвищення вартості фрахту суден тощо. Відповідні втрати в ціні зерна при експорті з України перекладаються по зерновому ціновому ланцюгу переважно на нижню його ланку – виробника зерна. Частка виробника (на умовах EXW) у експортній ціні пшениці 2-го класу зменшилася з 80 % на початку дії морського зернового коридору до 67 % при експорті морським зерновим коридором у лютому 2023 р.
Серйозні ризики для повоєнного відновлення українського експорту зерна становлять процеси релокації торговельних потоків на традиційних ринках експорту зернових з Чорноморського регіону, пов’язані, насамперед, із заміщенням українського зерна російським. Розвитку українського зернового експорту сприяло б максимальне дистанціювання від РФ у торговельній політиці щодо експорту продукції у межах Чорноморського регіону за рахунок залучення до торговельних потоків Середземноморського регіону з використанням конвенції щодо правил походження Пан-Євро-Мед.
THE DETERMINATION OF THE PARAMETERS OF THE MAIN ELEMENTS OF THE WIRELESS CHARGER FOR CHARGING AN ELECTRIC CAR BATTERY
Authors:   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine, Zharkin A.F. , Podoltsev O.D. ,   Institute of electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukrain, Pavlov V.B. ,   Institute of electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukrain
Published: August 2023

The work has developed a methodology for calculating voltage values on the main elements of the wireless battery charging system, which allows at the design stage of such systems to choose the necessary parameters of coils and an additional high-frequency transformer, while harmonizing the voltage value on the battery with the voltage at the output of the high-frequency inverter. A comparison of the calculation results using the developed methodology with the corresponding results obtained using the developed Simulink-model of the system showed that their maximum discrepancy does not exceed 15%. It is noted that in practice, when developing such systems to match the voltage of the rechargeable battery with the high-frequency inverter, it is possible to either use an additional high-frequency transformer, or choose the necessary ratio of turns of the transmitting and receiving coils. In the latter case, the possibility of high voltage resonance voltage on the coils and capacitive elements should be taken into account, which requires the use of reinforced insulation and the fulfillment of all requirements for the operation of devices at the corresponding high voltage. References 6, figures 3, table 1.
RESONANCE SYSTEM OF WIRELESS ENERGY TRANSMISSION WITH USING OF THE ELECTRIC FIELD
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Beresteiskyi Ave., 37, Kyiv, 03056, Ukraine, Vdovychenko A.V.
Published: August 2023

The paper reviews the existing types of wireless technologies for power transmission using electromagnetic interaction. According to the type of interaction, systems using magnetic, electric and electromagnetic components are distinguished. Short-range, medium-range and long-range systems are distinguished by range. As promising for implementation in future unmanned systems, the work considers a modified system of wireless transmission of electrical energy using an electric field. The scheme is presented and the principle of operation of such a system is considered. The characteristics of resonant circuits used as emitters and receivers in such a system were studied. The results of measuring the parameters of the spatial distribution of the electric field of the resonators are presented. The interaction of the spectral components of the input signal and the resonant characteristics of the radiating circuits was investigated. The paper presents the method of determining the efficiency of electric energy transmission at high frequencies and the results of measurement of transmission efficiency for the studied type of systems. It was concluded that there is an active factor in the form of an alternating electric field, the feature of which propagation allows creating a device suitable for powering unmanned mobile systems of low and medium power. References 11, figures 4, tables 2.
IMPROVED MATHEMATICAL MODEL OF THREE-WINDING ASYNCHRONOUS MACHINE
Authors:   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine, Mazurenko L.I. , Vasyliv K.M. ,   Lviv Polytechnic National university, 12, Bandera str., Lviv, 79013, Ukraine, Dzhura O.V. ,   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine
Published: August 2023

In phase coordinates, a mathematical model of a three-winding asynchronous machine with two windings on the stator as a structural element of electric drives and asynchronous generators with inverter and inverter-capacitor excitation for autonomous electric power plants, oriented to explicit methods of numerical integration of the system of differential equations, has been developed. The model takes into account the displacement angle between two stator windings in the range of 360º and other important factors affecting the course of electromagnetic processes occurring in the machine. On the basis of the mathematical model, a program code was developed as a means of computer verification of machine operation modes. The results of computer study performed with the help of the code confirm the suitability of the mathematical model of a three-winding asynchronous machine to take into account the influence of the displacement angle between the stator windings and their simultaneous and single power supply during the operation of the machine in motor mode. References 11, figures 10.
THREE-DEGREE-OF-FREEDOM ELECTRIC MACHINE WITH INTERNAL AND EXTERNAL ROTOR: COMPARATIVE ANALYSIS OF CONTROL PERFORMANCE
Authors:   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine, Petukhov I.S. , Kireyev V.G. ,   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine, Akinin K.P. ,   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine, Lavrynenko V.A. ,   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine
Published: August 2023

Two structures of electric machines with three degrees of freedom of the rotational movement of the rotor are considered - with an external and an internal rotor held on an internal cardan suspension. A three-plane symmetric magnetic system was chosen for the comparative analysis and such a choice was justified. Limitations are formulated that allow considering the rotor as a conservative mechanical system, as well as considering the magnetic field in the electric machine as magnetostatic. Mathematical models of the rotational motion of a body with a fixed center of mass, as well as the force interaction of the magnetic field of a permanent magnet located on the rotor and the control winding located on the stator, are given. The peculiarities of the distribution of electromagnetic forces in both structures are analyzed and the greater efficiency of the formation of these forces in the structure with an internal rotor is shown. Expressions for the components of the electromagnetic moment for use in the "COMSOL Multiphysics" interface are obtained. Forced precession movement for both structures was analyzed in the case of equal radii of the control windings and in the case of the same dimensions of the magnetic systems. It was determined that the structure with an external magnetic circuit is able to provide an order of magnitude smaller angular velocity of precessional movement and, at the same time, an equally smaller range of nutation. References 14, figures 10.
EFFICIENCY OF OPTICAL CALIBRATION IN HIGH PRECISION LASER RANGEFINDERS
Authors:   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine, Brahynets I.O. , Masjurenko Yu.O. ,   Institute of electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukrain
Published: August 2023

The effectiveness of the use of optical calibration in high-precision phase laser rangefinders has been evaluated. In order to ensure the specified accuracy of distance determination in order to establish the optimal frequency of distance measurement modes and optical calibration, an appropriate formula is recommended for estimating the switching frequency of signals at the input of the range finder measuring channel. It has been established that even when using optical calibration, the accuracy of distance measurement is affected by the error of the phase detector, which is part of the rangefinder. To minimize the influence of this error, a new method for the direct measurement of the phase shift in a range finder is proposed, as well as the use of a compensation method for measuring the phase shift. The corresponding block diagrams of rangefinders are considered, in which the proposed methods for measuring phase landslides are implemented, and analytical modeling of the processes that transform them is carried out. References 7, figures 2.
Physical Activity Among Adolescent Cancer Survivors: The PACCS Study
Authors: Grydeland May , Bratteteig Mari , Rueegg Corina S. , Lie Hanne C. , Thorsen Lene , Larsen Elna H. , Brügmann-Pieper Sabine , Torsvik Ingrid K. , Götte Miriam , Lähteenmäki Päivi M. , Kriemler Susi , Fridh Martin K. , Anderssen Sigmund A. , Ruud Ellen
Published: August 2023

OBJECTIVES

Physical activity (PA) may modify risks of late effects after cancer. We aimed to examine levels of PA and sedentary time (ST) in a large, international sample of adolescent childhood cancer survivors in relation to sociodemographic and cancer-related factors and compare levels of PA and ST to reference cohorts.

METHODS

Survivors from any cancer diagnosis who had completed cancer treatment ≥1 year ago, aged 9 to 16 years, were eligible for the multicenter Physical Activity in Childhood Cancer Survivors study. PA and ST were measured by ActiGraph GT3X+ accelerometers. We performed linear regression analyses to assess factors associated with moderate-to-vigorous PA (MVPA) and ST, and compared marginal means of total PA, MVPA, and ST in 432 survivors to sex- and age-stratified references (2-year intervals) using immediate t-tests for aggregated data.

RESULTS

Among survivors, 34% fulfilled the World Health Organization’s PA recommendation of ≥60 min of daily MVPA on average and their ST was 8.7 hours per day. Being female, older, overweight, a survivor of central nervous system tumor, or having experienced relapse were associated with lower MVPA and/or higher ST. Generally, male survivors spent less time in MVPA compared with references, whereas female survivors had similar levels. Both male and female survivors had higher ST than references in nearly all age groups.

CONCLUSIONS

The low PA and high ST in this large sample of adolescent childhood cancer survivors is worrisome. Combined, our results call for targeted interventions addressing both PA and ST in follow-up care after childhood cancer.
IDENTIFYING STUDENTS’ INFORMATION NEEDS IN THE ERA OF INFORMATION AND COMMUNICATION TECHNOLOGIES: IS SERBIA ON THE THRESHOLD OF CHANGE?
Authors: Peric Ana
Published: August 2023

The paper  presents the use of information and communication technologies (ICTs) in teaching and for research purposes at the Faculty of Architecture, University of Belgrade. The aim is to consider opportunities and representation of ICT use for the promotion of architectural education, and ways to overcome current barriers when using ICT as well. After giving a short review of the history of ICT, the current status and the level of ICT implementation at the Faculty of Architecture are briefly shown. Also, a survey was conducted to determine the extent to which students use ICT for research and learning. Respondents expressed their preferences regarding learning using electronic materials and services. The survey results highlighted solutions to help students in this era of information overload and rapid development of technology.      Key words: e-services; Faculty of Architecture, University of Belgrade; information and communication technologies; professional architectural education. --------------------------     U radu su prikazani načini uporabe informacijsko-komunikacijskih tehnologija (IKT) u nastavi i u istraživačke svrhe na Arhitektonskom fakultetu Sveučilišta u Beogradu. Cilj rada je provjera mogućnosti uporabe IKT za promociju arhitektonskog obrazovanja te načina za prevladavanje trenutnih prepreka prilikom upotrebe IKT-a. Nakon kratkog povijesnog pregleda IKT-a, prikazano je trenutno stanje i razina primjene IKT-a na Arhitektonskom fakultetu. Također, istraživanje je provedeno s ciljem da se utvrdi koliko studenti upotrebljavaju IKT prilikom istraživanja i učenja. Ispitanici su izrazili čemu daju prednost u vezi s primjenom elektroničkih materijala i usluga u svrhu učenja. Rezultati ankete prikazuju načine za pomoć studentima u eri preopterećenosti informacijama i brzog razvoja tehnologija.       Ključne riječi: Arhitektonski fakultet Sveučilišta u Beogradu, elektronički servisi, informacijsko-komunikacijske tehnologije, profesionalno obrazovanje arhitekata.
ANIMATIONS MADE IN MATLAB AND THEIR APPLICATION FOR DIDACTIC PURPOSES
Authors: Takaci Djurdjica , Dimovski Igor Nikola
Published: August 2023

The aim of this paper is to show how dynamic multimedia tool in Matlab (animation) can be made and how the animations and movies can be used for didactic purposes, or to be more precise, how they can be integrated into the teaching process. This paper is a part of a more complex research whose aim is to investigate the impact of the information technology on the quality of mathematical knowledge related to functions.     Analysis of the results of a research conducted on a sample of 30 students before and after performing the innovated teaching with the application of the information technology showed a significant impact of the IT application on the quality of knowledge related to functions. The t-test showed that, with the probability of 99%, it can be concluded that the results of the students after carrying out such type of innovated teaching were significantly better than their results on analogue contents taught through classical teaching.     Key words: animations created in Matlab, dynamic multimedia tools, integration of the educational ICT materials in teaching, movie (.avi file), verbal and visual learning -------------     Cilj ovog rada je pokazati kako se može načiniti dinamički multimedijski alat u Matlabu (animacija) i kako se animacije i filmovi mogu koristiti za didaktičke svrhe, ili, da budemo precizniji, kako mogu biti integrirani u nastavni proces. Ovaj rad je dio složenijeg istraživanja čiji je cilj istražiti utjecaj informacijske tehnologije na kvalitetu matematičkih znanja vezanih uz funkcije.     Analiza rezultata istraživanja, provedenog na uzorku od 30 studenata prije i nakon izvođenja inovativne nastave uz primjenu informacijskih tehnologija, pokazala je značajan utjecaj primjene informacijskih tehnologija na kvalitetu znanja vezanih uz funkcije. T-test je pokazao da se, uz vjerojatnost od 99%, može zaključiti da su rezultati studenata nakon izvođenja ovog oblika inovativne nastave bili znatno bolji od rezultata iste skupine studenata na analognim sadržajima tijekom klasične nastave.     Ključne riječi: animacije stvorene u Matlabu, dinamički multimedijski alati, integracija ICT obrazovnih materijala u nastavi, film (.avi datoteka.), verbalno i vizualno učenje
DIFFERENCES IN MOTOR ABILITIES OF MALE AND FEMALE FIFTH AND SIXTH GRADE PUPILS / RAZLIKE U MOTORIČKIM SPOSOBNOSTIMA IZMEĐU UČENIKA I UČENICA 5. I 6. RAZREDA
Authors: Badrić Marko
Published: August 2023

SUMMARY  The aim of this study is to determine whether there is a statistically significant difference in motor abilities of boys and girls in the fifth and sixth grade. Discriminant analysis results showed a statistically significant difference between boys and girls in the fifth and sixth grade in motor abilities (p=0,00). The most signifiicant differences are observable in coordination and explosive strength in favor of boys (p=0.00) and flexibility in favor of girls (p=0.00). Based on the obtained results, it can be concluded that boys and girls differ in motor abilities at the age of 11. Boys are more dominant in the abilities that develop under the influence of physical exercise, while girls show much better results in flexibility. It can therefore be concluded that irregular exercise results in poorer development of motor abilities in girls than in boys. Key words: anthropological characteristics, gender differences, school   ----   SAŽETAK  Cilj rada je utvrditi postoji li statistički značajna razlika u motoričkim sposobnostima između učenika i učenica 5. i 6. razreda osnovne škole. Rezultati diskriminacijske analize pokazuju postojanje statistički značajne razlike između dječaka i djevojčica 5. i 6. razreda u motoričkim sposobnostima (p=0,00) i ta se značajnost povećava porastom dobi. Najveće razlike očituju se u prostoru koordinacije i eksplozivne snage u korist dječaka (p=0,00) i fleksibilnosti u korist djevojčica (p=0,00). Na osnovi dobivenih rezultata može se zaključiti da se dječaci i djevojčice razlikuju u motoričkim sposobnostima već  od 11. godine. Dječaci su dominantniji u sposobnostima koje se razvijaju pod utjecajem tjelesnog vježbanja, dok djevojčice pokazuju puno bolje rezultate u fleksibilnosti. Zasigurno se može zaključiti da neredovito tjelesno vježbanje rezultira slabijim razvojem motoričkih sposobnosti kod djevojčica u odnosu na dječake.              Ključne riječi: škola, antropološka obilježja, spolne razlike
NEWS AND EVENTS / NOVOSTI I DOGAĐANJA
Authors: Zalar Diana , Jurčević Lozančić Anka
Published: August 2023

NOVI SVEUČILIŠNI PROGRAMI ODGOJITELJSKIH STUDIJAUČITELJSKOG FAKULTETA SVEUČILIŠTA U ZAGREBU•Preddiplomski sveučilišni studij ranog i predškolskog odgoja i obrazovanja•Diplomski sveučilišni studij ranog i predškolskog odgoja i obrazovanja