bluuebunny/crossref_metadata_2025 huggingface dataset:
An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy
Authors: Yang Yi , Denton Harriet , Davies Owen R. , Smith-Jackson Kate , Kerr Heather , Herbert Andrew P. , Barlow Paul N. , Pickering Matthew C. , Marchbank Kevin J.
Published: March 2018

Background C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway of complement activation, and treatment options for C3G remain limited. Complement factor H (FH) is a potent regulator of the alternative pathway and might offer a solution, but the mass and complexity of FH makes generation of full-length FH far from trivial. We previously generated a mini-FH construct, with FH short consensus repeats 1–5 linked to repeats 18–20 (FH1–5^18–20), that was effective in experimental C3G. However, the serum t
1/2 of FH1–5^18–20 was significantly shorter than that of serum-purified FH.

Methods We introduced the oligomerization domain of human FH-related protein 1 (denoted by R1–2) at the carboxy or amino terminus of human FH1–5^18–20 to generate two homodimeric mini-FH constructs (FHR1–2^1–5^18–20 and FH1–5^18–20^R1–2, respectively) in Chinese hamster ovary cells and tested these constructs using binding, fluid-phase, and erythrocyte lysis assays, followed by experiments in FH-deficient Cfh−/− mice.

Results FHR1–2^1–5^18–20 and FH1–5^18–20^R1–2 homodimerized in solution and displayed avid binding profiles on clustered C3b surfaces, particularly FHR1–2^1–5^18–20. Each construct was >10-fold more effective than FH at inhibiting cell surface complement activity in vitro and restricted glomerular basement membrane C3 deposition in vivo significantly better than FH or FH1–5^18–20. FH1–5^18–20^R1–2 had a C3 breakdown fragment binding profile similar to that of FH, a >5-fold increase in serum t
1/2 compared with that of FH1–5^18–20
, and significantly better retention in the kidney than FH or FH1–5^18–20.

Conclusions FH1–5^18–20^R1–2 may have utility as a treatment option for C3G or other complement-mediated diseases.
Efeitos do contrato psicológico na afetividade e satisfação no trabalho de auditores
Authors: Santos Vanderlei dos , Pazetto Celliane Ferraz , Wilvert Nicolle Raitz , Beuren Ilse Maria
Published: March 2018

Para além dos contratos formais entre empregados e empregadores, há os contratos psicológicos, relativos às crenças individuais sobre as obrigações recíprocas. Neste estudo objetiva-se verificar os efeitos do contrato psicológico na satisfação no trabalho, mediado pela percepção de afetividade dos auditores. Uma pesquisa de levantamento foi realizada. Teve como população os auditores das empresas Big Four, em que se levantou uma amostra de 116 respostas válidas. Aos dados da pesquisa foi aplicada a técnica de Modelagem de Equações Estruturais (SEM). Os resultados evidenciam que as percepções de obrigações do empregado para com a empresa não apresentaram relações significativas com nenhuma variável da pesquisa (afetividade positiva, afetividade negativa e satisfação no trabalho), ao passo que o contrato psicológico na perspectiva de obrigações do empregador influencia na afetividade positiva e na satisfação no trabalho. Constatou-se ainda que a afetividade positiva medeia a relação entre contrato psicológico de obrigações do empregador com a satisfação no trabalho. Confirma-se, assim, a crença de que as obrigações na relação contratual podem proporcionar estabilidade e desenvolver o lado profissional dos auditores, provocando sentimentos positivos e satisfação na realização das atividades, o que supostamente se refletirá em melhores resultados individuais e organizacionais. Conclui-se que o contrato psicológico na perspectiva de obrigações do empregador desencadeia afetos positivos no ambiente de trabalho dos auditores, que, por sua vez, se reflete em maiores níveis de satisfação, mas instiga a não significância para as percepções de obrigações do empregado para com a empresa, o que pode ser objeto de futuras investigações.
Introduction: Intelligent Learning Assessment in Serious Games
Authors: Berta Riccardo , Moreno-Ger Pablo
Published: March 2018

There is a consensus that Serious Games (SGs) have a potential as a tool for education, and the conversation is no longer about whether it makes sense to use SGs in education, but how to exploit their potential to become a revolution is to become effective in the evaluation of the learning progress of the player. The aim of this special issue is to presents some recent in the field of assessment of learning.
Quick Protocol for Monarch® PCR & DNA Cleanup Kit (5 ?g) (NEB #T1030) v3
Authors: England Biolabs New
Published: March 2018

This is the "quick" version of Monarch® PCR & DNA Cleanup Kit (5 μg) Protocol (NEB #T1030). For the full protocol, please clickhere.
Ölçek Geliştirme Çalışmalarında Kullanılan Kapsam Geçerliği İçin Bir Yol Haritası
Authors: Yeşilyurt Selami , Çapraz Cüneyt
Published: March 2018

Bu çalışmanın amacı kapsam
geçerlik oranları ve kapsam geçerlik indeksi tanıtılarak kapsam geçerlik
çalışmalarının ne şekilde yapılabileceği ile ilgili çalışmacılara bir yol
haritası sunmaktır. Yol haritası, örnek bir çalışma üzerinden, Lawshe (1975)
tarafında geliştirilen teknik ile Ayre ve Scally (2014) tarafından belirtilen
ölçütler dikkate alınarak verilmiştir. Örnek çalışmaya 26 uzman katılmıştır.
Veri toplama aracı olarak 66 maddenin sorgulandığı “Uzman Formu”
kullanılmıştır.
Dis-Equality: Exploring the Juxtaposition of Disability and Equality
Authors: Byrne Bronagh
Published: March 2018

The (in)equality issues facing disabled people are extensive and long-enduring. The way(s) in which equality is conceptualised has important consequences for understandings of disability. The ambiguity of what I call dis-equality theory is two-fold; the apparent failure of mainstream equality theorising in, firstly, embracing disability concepts at all, and secondly, in fully incorporating the logistics of disability, particularly in relation to the social construction of such. Practices of institutional and more complex forms of discrimination are part of those deeper structures of domination and oppression which maintain disabled people in positions of disadvantage. Everyday practices, in the ‘ordinary order of things’ (Bourdieu, 2000), continue to be misrecognised as natural and taken for granted. This article critically explores the complexity of dis-equality theorising utilising a Bourdieusian lens which explicitly incorporates complex and subtle forms of discrimination, and by examining the UN Convention on the Rights of Persons with Disabilities’ approach to equality. I argue that the way forward for dis-equality theorising in today’s rights based era must be one that considers the nuances of the ‘rules of the game’ (Young, 1990) if it is to be effective in challenging the inequalities to which disabled people have long been subject.
Data Mining Through Data Visualization: A Case Study on Predicting Churners on Telecomunications Data Set
Authors: BASARSLAN Muhammet Sinan , KAYAALP Fatih
Published: March 2018

Data mining is the

process of extracting meaningful information from a large, raw data. These

processes are carried out by various, detailed methods. And, the obtained

results are used to make various interpretations and to draw conclusions.

Deductions can either be made by interpreting the data after various operations

or by plotting the data in various forms of graphs. This type of interpretation

over graphics is called data mining through data visualization. Generating

graphs that can be used to draw various conclusions on a telecommunications

data set with the help of some packages included in the R program is presented

in the paper. It does not require upper-level math skills to interpret these

graphics; and everyone having knowledge about the industry and data set of the

graphs has the ability to plot similar graphs and make analysis and

interpretations regarding the results obtained on the data set at hand. In this

study, R language was preferred as the software infrastructure for data mining

applications, and graphs were plotted for interpretation through data

visualization with data mining.
Noise Adaptive and Similarity Based Switching Median Filter for Salt & Pepper Noise
Authors: KATIRCIOGLU Ferzan
Published: March 2018

Works have been

conducted recently to remove high intensity salt & pepper noise by virtue

of adaptive and switching median filters. One of the cited works is the

Noisy Adaptive Fuzzy Switching Median Filter (NAFSM) by which the noisy pixels

are detected through utilization of image histogram. Noiseless pixels are

left unprocessed while noisy pixels are passed through the noise adaptive

median filter which expands for them. A filter mechanism which performs

decision making in line with local similarity and similarity has been proposed

for NAFSM. Local similarity information in 3x3 mask has been used for

filtering mechanism in the study titled Noise Adaptive and Similar Based

Switching Median Filter (NASBSM). Two thresholds with three regions were

made by virtue of local similarity information. The logic of the approach

was based on more intensive filtering for noisy pixels with high similarity

value with neighboring pixels and less for those with less similarity value

with neighboring pixels. According to the numerical and visual simulation

results of the NASBSM mechanism, it was detected that it eliminates noises with

high density.
Classification of Different Cancer Types by Deep Convolutional Neural Networks
Authors: NOGAY H. Selcuk
Published: March 2018

In this study, ten

different types of cancer were classified with deep convolutional neural

networks (DCNN). A total of 10,000 MRI (Magnetic Resonance Imaging) data were

used for ten cancer patients, including 1000 MRI data for each cancer type.

Although the images were reduced to 28x28 pixels, the DCNN model performed

classification with an accuracy rate of 0.98 after 27 seconds and 15 epochs of

training. The error rate in the last epoch in the study is also very close to

zero. A highly successful classification has been achieved with the proposed

DCNN model.
ISOLATION OF BACTERIOPHAGES, CAPABLE TO LYSE SERRATIA MARCESCENS AND EVALUATION OF THEIR ACTIVITY ON ONION AND GERANIUM
Authors: Kharina A. , Kornienko N. , Stavniychuk A. , Kot T. , Liptuga M.
Published: March 2018

In this study, phages active against S. marcescens, causative agent of onion decay, were isolated from plant material. One virus isolate was shown to accumulate in high titers and was denoted as phage S. This bacteriophage exhibited a hexagonal head and tail and was attributed to Myoviridae family. It was shown the ability of bacteriophage S to suppress the development of bacteriosis on geranium plants. Investigated virus isolate also inhibited rooting of onion scales. This work focused on a biological control approach to use bacteriophages for reducing bacterial pathogen populations and disease severity on plants.
MICROMORPHOLOGICAL FEATURES OF THE NARROW ENDEMIC SILENE SYTNIKII (CARYOPHYLLACEAE) COMPARED WITH CLOSELY RELATED SPECIES
Authors: Martynyuk V. , Karpenko N. , Tsarenko O.
Published: March 2018

Silene sytnikii Krytzka, Novosad et Protopopova is a local endemic species of the Ukrainian flora, which sometimes is considered as a synonym to the S. frivaldszkyana Hampe from the Balkans and is related to the widespread species S. chlorantha (Willd.) Ehrh. The aim of the present study is to investigate micromorphological features of seeds, pollen grains and leaf surface ultrastructure of foregoing species and make a comparison. Both light and scanning electron microscopy were used in the study. S. sytnikii and S. frivaldszkyana are slightly different in the size of exotesta cells and their anticlinal teeth in distal row of seeds, pollen diameter and microechinate number on the pore, size of leaf spinule, epidermal cells and stomata. S. chlorantha significantly differs from them by smaller seeds and exotesta cells, and also longer leaf spinules. Thus, S. sytnikii and S. frivaldszkyana are quite similar in their micromorphology, while S. chlorantha is clearly distinct from them.
MISSING IN MIGRATION: FROM RESEARCH TO PRACTICE1
Authors: Robins Simon
Published: March 2018

Persons who die or go missing in migration leave behind families with similar needs to the families of those missing in conflict and political violence. Indeed, much of what has been learned in terms of psychosocial support and forensic work in transitional contexts may be useful in such situations. However, both the political and logistical constraints of identifying the bodies of dead migrants, for example those found in the Mediterranean Sea, are extreme, with families dispersed globally and European states refusing to acknowledge that they have any obligations. Here, experience of a research project investigating the treatment of migrant bodies at the European Union's southern frontier and the needs and perceptions of families of missing migrants is discussed, with an emphasis on work with both families and practitioners.
ÍNDICE SPAD EM PLANTAS DE TOMATEIRO CULTIVADO EM FIBRA DE COCO E SUBMETIDO A PULSOS DE FERTIRRIGAÇÃO
Authors: Nogueira B. B. , Iglesias L. , Mesquita J. V. , Nakatani M. C. , Putti F. F.
Published: March 2018

O tomate é uma das principais hortaliças produzidas no Brasil, adaptando-se a praticamente todos os climas, porém está susceptível a diversas doenças que acarretam na redução da produtividade e da qualidade. Um dos segmentos mais importantes no mercado brasileiro é o tomate de mesa, entra nessa categoria o híbrido ‘BRS Imigrante’, que é tolerante a doenças que causam prejuízos na produção. A clorofila está presente em todos os vegetais e é um dos fatores relacionados à eficiência fotossintética de plantas e como consequência ao seu crescimento, desenvolvimento e adaptação a diversos ambientes. O experimento foi conduzido em casa de vegetação na área experimental da empresa Proteto. Adotou-se o sistema de bloco ao acaso, com 10 avaliações ao longo do ciclo da cultura, com 3 repetições. A irrigação adotada foi em pulso, sendo que aproximadamente a cada 20 minutos ocorria o acionamento do sistema. Sendo avaliado. Visto a importância da clorofila, o objetivo desse trabalho foi analisar a clorofila A, B e Total por meio de dos índices SPAD A, B e total e investigar o seu comportamento ao longo do desenvolvimento da cultivar. Os índices SPAD analisados apresentaram correlações positivas e significativas entre eles.
ESTUDO COMPARATIVO DO MÉTODO PADRÃO DA ESTUFA E DO MÉTODO SPEEDY NA DETERMINAÇÃO DO TEOR DE ÁGUA NO SOLO
Authors: Ribeiro K. M. , Castro M. H. de C. , Ribeiro K. D. , Lima P. L. T. , Abreu L. H. P. , Barros K. L. C.
Published: March 2018

A umidade do solo determina a quantidade de água retida nos espaços porosos do solo. O conhecimento desta propriedade é de suma importância, pois a água pode alterar o comportamento do solo. Dentre os métodos utilizados na avaliação dessa propriedade para avaliar essa propriedade destaca-se o método do speedy e o método da estufa. O objetivo desse trabalho foi comparar os resultados de umidade do solo obtidos através do método gravimétrico padrão de secamento em estufa e do método speedy. Foram coletadas amostras em triplicata de quatro classes de solo (Latossolo Vermelho, Latossolo Vermelho-Amarelo, Cambissolo e Argissolo), oriundas da cidade de Lavras – MG, provenientes da Universidade Federal de Lavras – UFLA, e analisadas em laboratório quanto a sua granulometria e umidade. Para determinar a umidade das amostras foram seguidos os procedimentos referentes as normas NBR 6457 para o método da estufa e as normas do Departamento Nacional de Estradas de Rodagem (DNER-ME 052/94) para o método do speedy. Foi possível verificar que o método do speedy forneceu valores de umidade abaixo daqueles determinados pelo método da estufa, possivelmente em virtude da dificuldade de desagregação total das partículas no interior do aparelho, de modo que, quanto maior a umidade do solo, mais os valores obtidos pelo método do speedy se afastaram daqueles obtidos pelo método da estufa. Observando-se as divergências encontradas, análises de regressão linear foram realizadas para obter uma equação de calibração do método do speedy para se atingir um valor mais aproximado do método da estufa. O modelo que melhor se ajustou foi hSC= 46,292254 – 333,088487 / hSD, apresentando um R² = 0,8843.
Study on umbilical cord arterial blood gas analysis and cord blood lactate levels as predictors for adverse neonatal outcome: an observational study
Authors: Patil Suman Shivanagouda , . Sukanya , Rath Suman , George Carolin Elizabeth
Published: March 2018

Background: Perinatal asphyxia is a major cause of neonatal and childhood morbidity and mortality. Electronic foetal monitoring is used routinely to know the condition of the baby during Intrapartum period. Normal trace correlates highly with absence of acidemia at birth. Abnormal trace needs further evaluation. In order to better define the metabolic status of the new born, umbilical lactate levels have been measured. Objectives of this study were to determine the validity of umbilical cord blood lactate levels in predicting the adverse early neonatal outcome in babies with intrapartum foetal distress and to compare the validity of umbilical cord blood lactate and umbilical artery pH in predicting adverse neonatal outcome in babies with intrapartum foetal distress.Methods: 295 pregnant women with abnormal CTG in active labour were subjected for estimation of cord blood lactate and umbilical artery pH immediately after delivery and were compared in predicting adverse neonatal outcome.Results: In the present study specificity of serum lactate (97.7%) and umbilical artery pH (95.97%) was almost similar in babies with Apgar <7 at 1 minute and 5 minutes, but sensitivity of serum lactate (23.14%) and cord ph (31.4%) was less in babies with Apgar score ≤7 at 1 minute. Area under ROC showed serum lactate is more accurate in predicting adverse neonatal outcome compared to umbilical artery pH.Conclusions: Umbilical cord blood lactate is more specific than umbilical artery pH in predicting adverse neonatal outcome. Area under ROC (at 95th percentile) shown serum lactate is more accurate in predicting adverse neonatal outcome compared to umbilical artery pH at birth.
Awareness and practice of contraceptive methods among women in Kerala, India
Authors: Alukal Anila Tresa , George Lissiamma , Raveendran Resmy C.
Published: March 2018

Background: India is the second most populous country in the world, sustaining 17.01% of world population on 2.4% of world’s surface area. Indian women have more children than desired and often too close together. Family Planning can have a positive impact on population growth, maternal mortality, and infant and new-born outcomes. In spite of availability of wide range of contraceptives, the unmet need for family planning is estimated to be 12.8%. The purpose of this study is to assess awareness of the effective use of contraceptive methods among pregnant women, which will provide useful information for future intervention strategies and the reduction of unwanted pregnancies.Methods: The study was conducted at the Government Medical College Thrissur, Kerala and study period was 1year (2014-2015). The awareness and contraceptive practices of 514 pregnant women who were admitted for delivery were assessed by using questionnaire. The data was entered in MS excel sheet and analysed using SPSS software.Results: the awareness regarding barrier method of contraception was maximum. (96.7%), followed by permanent methods (96.8%), IUCD (94.9%) and natural methods (92.6%). Around 71.6% of the study population has used some form of contraception. The most commonly contraceptive method was natural methods (69.6%) followed by barrier method (59.9%). IUCD was the method which was least practiced (2.9%) followed by OC pills (19.1%).Conclusions: Even though women are well aware of most of the contraceptive methods, the percentage of women using it is very low. This shows that there is good knowledge regarding contraceptive methods, but a change is needed in the attitude and practice.
Study of congenital fetal malformations among antenatal women in a tertiary care centre
Authors: More Vibha Subhash , Vaidya Annal Abhay , Parelkar S. V. , Prasad Madhva
Published: March 2018

Background: Congenital malformations are morphological or functional anomalies that occur in the prenatal period as a result of genetic mutation, chromosomal abnormalities and adverse intrauterine environment. Early recognition is important. If congenital malformations are detected beyond the period of legal limit for medical termination of pregnancy, it carries immense burden on the pregnant woman.Methods: A descriptive observational study was conducted as a retrospective analysis of patient-records, over a span of 9 consecutive months in the Department of Obstetrics and Paediatric Surgery, at a tertiary care centre, Mumbai. The project was carried out to study demographic profiles, risk factors and system-wise distribution of pregnant women carrying malformed fetus.Results: The average annual incidence rate was 29 per 1000 deliveries. Of 151 patients, renal malformations were the commonest accounted for 40% of all congenital malformations. This was followed by central nervous system 32%, cardiovascular 14%, gastrointestinal 8% and musculoskeletal 3%. Congenital malformations were more common in multigravida than primigravida. 92% of congenital malformations were detected beyond 20 weeks of gestation. Previous abortions, hypothyroidism and raised sugars were associated high risk factors.Conclusions: The diagnosis of congenital malformation using ultrasonography occurs at a later gestational age than 20 weeks. For these patients a combined approach of the obstetrician/neonatologist/paediatric surgeon allows better counselling of parents and to permit preparation of the team to optimize neonatal outcomes.
Analysis of caesarean section in a tertiary care hospital, Assam, India
Authors: Banerjee Alaka , Bhadra Banasree , Dey Kiriti R.
Published: March 2018

Background: One of the commonest surgery performed worldwide is caesarean Section (CS). The World Health Organization (WHO) has identified an ideal caesarean section (CS) rate for a nation of around 10-15%. In recent times the proportion of delivery conducted by caesarean section has increased.Methods: This is a retrospective study of all the caesarean deliveries performed between 1st January 2010 to 31st December 2018 in the Department of Obstetrics and Gynaecology in Silchar Medical College. The caesarean rate was calculated as: (total number of caesarean deliveries/ total number of deliveries) × 100. The indications for CS included foetal distress, malpresentation, previous caesarean section, multiple gestation, failed induction, failed progression, cephalopelvic disproportion, maternal indications, obstetric indication and foetal indications.Results: During the study period a total of 75685 patients delivered. 25805 patients had undergone CS with the CS rate being around 34.1%. Majority of the CS (75.6%) were performed as emergency procedure. Maximum number of patients were between 21-30 years (73.24%) and 54.47% were primipara. Majority of the patients (68.37%) belonged to the rural areas. Foetal distress (32.8%) was the commonest indication followed by post caesarean pregnancy (26.76%).Conclusions: The rate of caesarean section is increasing with time. As primary caesarean section usually determines the lady’s future obstetric course, it is of prime importance to give effort for safe reduction of caesarean. Individualization of the indication and careful evaluation, following standardized guidelines and practice of evidenced-based obstetrics followed by audits in the institution, can help us limit the caesarean rates.
Spontaneous isolated bladder rupture following normal delivery
Authors: Diana Valsa , K. Bhargavi
Published: March 2018

Spontaneous bladder rupture in a primipara after normal delivery within the first week of puerperium is a rare surgical emergency. The importance of suspecting and recognizing the voiding dysfunction in the postpartum period and early catheterisation to prevent such catastrophe is highlighted in this case report. We report a case of spontaneous intraperitoneal bladder rupture in a 26 year old primipara 3 days after normal delivery of a 3kg baby with episiotomy
An observational study of 100 cases of 25μg oral misoprostol for induction of labour in term pregnancy
Authors: Gupta Nidhi S. , Prajapati Shetal S.
Published: March 2018

Background: Labour induction is a clinical intervention that has the potential to confer major benefits to the mother and new born when continuation of pregnancy poses a risk/danger to the outcome of pregnancy. Misoprostol is an ideal agent for induction of labour, particularly in settings where the use of prostaglandin E2 is not possible owing to lack of availability, facilities for storage, or financial constraints. It is stable at room temperature, relatively inexpensive and can be given via several routes (oral, vaginal, sublingual, and buccal).Methods: It is an observational study of 100 cases conducted in the labour room of a Tertiary Care Government Hospital, Rajkot over a span from January 2016 to March 2017. After patient selection as per inclusion criteria and written informed consent after evaluating patients were enrolled in the study. Tablet misoprostol 25 microgram given orally every 4 hourly with maximum of 5 doses till the patient was in active stage of labour.Results: Maximum patients delivered by a single dose of Tab. Misoprostol (35%), the mean induction delivery interval was 11.44 hours. Most of the women delivered by vaginal route (88%) without any maternal complications like PPH, cervical/vaginal tear and uterine rupture. Only 4 cases out of 100 of failed induction for which LSCS was taken. Eight babies were admitted in NICU for MSL and had good prognosis. The most common side effect of the drug was nausea (15%) followed by fever and vomiting. 69% patients did not have any adverse drug reaction.Conclusions: Thus, induction of labour with oral misoprostol reduces the LSCS rates, lesser induction delivery interval and has good fetal outcome. The drug is well tolerated by the patients orally and has very few side effects.
Pregnancy with thalassemia: challenges and outcomes
Authors: Berwal Vidhika , Kyal Amit , Dessa Dorothy , Bhowmik Joyita , Mondal Payel , Mukhopadhyay Partha
Published: March 2018

Background: Thalassemia syndromes are autosomal recessive disorders and the most commonly inherited haemoglobinopathies in the world. HbE β is the most common type of thalassemia in eastern India. The objectives of the study include maternal outcome and complications like anemia, hypertensive disorders, gestational diabetes mellitus and also to study the neonatal outcome in terms of low birth weight, prematurity and other complications.Methods: A prospective longitudinal study carried out over a period of one year from July 2016 to June 2017 in Medical College, Kolkata. Fifty antenatal thalassemic mothers over 20 weeks of gestation during study period were enrolled in after institutional ethical clearance and consent from study subjects. All necessary investigations (complete haemogram, reticulocyte counts, Ultrasounds etc.) were done followed by statistical analysis.Results: Out of total 50 diagnosed thalassemic patients, maximum were HbE Beta Thal i.e. 54.0%. The mean level of iron in these women varied from 95.70±17.16µg/dl to 99.46±18.19µg/dl at the time of delivery and ferritin varied from 185.40±49.26µg/L vs 194.13±48.80µg/L. The mean blood transfusion done was 6.84 Units. Incidence of maternal complications were variable, PIH was found to be 26% whereas it was just 8% for GDM. The mean gestational age at delivery (Mean±SD) was 36.30±2.08 weeks. NICU admission was high (50%).Conclusions: Pregnancy with thalassemia is considered high risk, continuous pre-conceptional, antenatal and postpartum assessment should be done for favorable outcomes.
Cyclical hematuria-ureteral endometriosis: a case report
Authors: Ravula Sindura Ganga , Shetty Harish , Rajesh Aparna
Published: March 2018

Little attention has been paid for the renal involvement in endometriosis, a rare and silent disorder which ultimately lead to renal failure. Involvement most commonly may be limited to single ureter (left one) and it is usually involvement extrinsically. Although cases have been reported in the literature, true incidence of ureteral involvement is still not known. The diagnosis is difficult as the disease has non-specific symptoms. Only high index of suspicion with radiological support would be helpful in early diagnosis. Early cases may be benefited with progestin or Anti-aromatase therapy, most cases need surgery, either laparoscopically or laparotomy.
A rare presentation of ovarian fibrothecoma: a diagnosing dilemma
Authors: Logesh Kalaivani , Prasanna Latha
Published: March 2018

Ovarian Fibrothecoma are uncommon tumors of gonadal stromal cell origin accounting for 3-4% of all ovarian tumours. Ovarian fibrothecoma are composed of an admixture of fibrous and the comatous elements. The stromal cell tumors are probably the most inaccurately diagnosed tumor of the female gonad, clinically and histologically. Rarely benign tumours can present with elevated CA125. Here we discuss a rare presentation of Ovarian Fibrothecoma in a 52 years postmenopausal woman with large pelvic mass with ascites and elevated CA125 which we mistook for malignancy. Hence accurate diagnosis is more important before extensive surgical intervention.
Live second trimester intrauterine pregnancy with invasive mole: a rare case report
Authors: Chhabra Muskaan , Daver Rekha
Published: March 2018

Gestational trophoblastic disease or gestational trophoblastic neoplasia is a collective term used to describe hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumours. Since any molar pregnancy has the potential to develop into invasive mole these patients should be carefully monitored for development of malignant disease. Here we are reporting a case of invasive molar pregnancy with a single live fetus of 17 weeks gestational age. A 24 years old woman, G3P2L2 with a history of amenorrhea since approximately 5 months presented with profuse per vaginal bleeding. Ultrasound showed presence of live fetus of approximate gestational age of 17 weeks. Along with the fetus there was also presence of cystic areas with no vascularity s/o Hydatiform mole. In view of continued bleeding and severe anemia pregnancy was terminated and fetus along with vesicular tissue was expelled. On follow up Beta hcg titers showed increasing trend over the next week. Repeat USG showed extension of molar tissue into the myometrium. In view of this she was given 3 cycles of chemotherapy and eventually was discharged. She was followed up regularly with no e/o recurrence. Presence of viable fetus along with hydatiform mole is a rare occurrence in obstetric practice. After termination of pregnancy these patients should undergo follow up ultrasound and serial beta HCG titers to detect the malignant transformation. Rising beta HCG titers and invasion of myometrium on ultrasound are the ominous features suggesting malignant transformation and should be treated accordingly.
Pancreatic ductal adenocarcinoma in a Moroccan population: analysis of six years experience
Authors: Bazine Aziz , Fetohi Mohamed , Tores Mehdi , Tanz Rachid , Tahiri Moulay El Hassan , Choho Abdelkrim , Ichou Mohamed
Published: March 2018

Background: Few studies have been done to investigate pancreatic cancer in Morocco. Therefore, the aim of our study was to describe the epidemiological, clinical and therapeutic features of pancreatic ductal adenocarcinoma in Moroccan population.Methods: Author retrospectively reviewed the medical data of pancreatic ductal adenocarcinoma patients presented to the Medical Oncology Department of the Military Hospital Moulay Ismail in Meknes, Morocco, from January 2011 to December 2016.Results: The study included 67 cases of pancreatic ductal adenocarcinoma. The mean age of patients was 61.24±10.35 years. Male/female ratio was 3.2/1. 20.9% of patients were cigarette smokers, 10.5% alcoholics. 23.9% diabetics, 3.0% with a positive family history of pancreatic cancer and 25.4% with a family history of diabetes mellitus. The main symptoms for consultation were weight loss (68.6%), abdominal pain (64.2%), jaundice (53.7%) and vomiting (25.4%). The tumour was located to the pancreatic head in 71.6% of cases. Stage IV disease was the most common stage representing 47.8% of patients. Biliary and duodenal stent placements were respectively performed in 10.4% and 3.0% of patients. 23.9% of patients underwent curative surgery, 7.5% had palliative surgery and 86.6% received chemotherapy. The median overall survival for the entire cohort was 9.3 months (95% CI 7.2-12.1 months) with a median follow-up of 9.7 months (2-63 months).Conclusions: The data on pancreatic ductal adenocarcinoma in Moroccan population are similar to the epidemiologic literature data. With multimodality treatments, the results in terms of survival benefit seem to be similar to those in Asian and Caucasian populations.
Comparative study of incidence, risk factors, etiological agents and outcome of early and late ventilator associated pneumonia in paediatric intensive care unit at a tertiary care centre
Authors: Malhotra Preeti , Kumar Naresh , Thapar Karuna , Bagga Amanjeet Kaur
Published: March 2018

Background: Ventilator Associated Pneumonia (VAP), the nosocomial pneumonia developing in mechanically ventilated patients after 48 hours of mechanical ventilation, is the second most common nosocomial infection in the paediatric intensive care unit (PICU). VAP occurring within 96 hours of initiation of mechanical ventilation is termed as early VAP and later than that is known as late VAP. The aim of this study was to determine the incidence rate, risk factors and bacteriological profile and outcome of early and late ventilator associated pneumonia in PICU.Methods: The study was conducted from December 2015 to November 2017 in which 89 children beyond 1 year of age were ventilated for more than 48 hours of which those who developed VAP as per CDC criteria were enrolled in the study. The endotracheal secretions were collected, processed and recorded as per standard microbiological methods. Statistical associations were further evaluated between various parameters of VAP and time of development of VAP.Results: Of all the mechanically ventilated patients, 33.7% developed VAP. Incidence of Early VAP was 23.3% and that of Late VAP was 76.67%. Duration of mechanical ventilation and re-intubation were significantly associated with the time of development of VAP. Micro-organisms identified by culture, involved in the aetiology of VAP were: gram-negative bacteria in 74.9% and gram-positive bacteria in 25.1%. The overall mortality rate was 43.33%.Conclusions: Re-intubation and duration of mechanical ventilation are a significant risk factor for development of late VAP. Overall the most common Gram-negative bacteria associated with VAP was Acinetobacter baumanii. The most common isolate in early VAP was Acinetobacter baumanii whereas infections by Pseudomonas and E. coli are common in late VAP. population.
Doctor becomes a patient: a qualitative study of health care work place violence related perception among junior doctors working in a teaching hospital in India
Authors: Joshi Sudhir Chandra , Joshi Rita
Published: March 2018

Background: Health care work place violence (HCWPV) is four times higher compared to violence against other professions. The problem remains under-reported and under-researched. Qualitative perception studies among junior doctors have not been paid due attention hitherto.Methods: Six individual face-to-face-indepth-interviews and six focus-group-discussions were conducted during December 2017 and January 2018 among 41 young doctors (interns, resident doctors i.e. post graduate students and young clinical faculty members). Thematic (content) analysis method was used for analysis of the data (texts).Results: Relevance, causes as well as consequences of HCWPV and measures for its prevention and control were brought up and discussed. Four themes emerged in thematic analysis. Almost all of the participants believed that it is an extremely important topic. Causation is multifactorial whereby all stakeholders are responsible. Consequences are affecting the whole society not merely the victims. Measures suggested were related to - in view of the causes - medical profession; patients and society; behavior and process; system and administration.Conclusions: Increasing materialism and eclipse of humanitarian values, media-created-violence, negative image of medical profession, patient-physician-distrust, zero-protection for doctors, apathetic governments and deficiencies in the process of justice are among the main causes of HCWPV. Junior doctors were not much optimistic of any improvement in near future in their safety and security as this would require more probity and unity among doctors and a clientele, a Health Care Delivery System, the Governments and a Judiciary much different from what it is today.
Prevalence and causes of visual impairment and blindness among school children in Muzaffarabad, Pakistan
Authors: Awan Abdul Rauf , Jamshed Junaid , Khan Muhammad Mushtaq , Latif Zahid
Published: March 2018

Background: Vision loss in childhood has serious implications in all stages of child’s growth and development. It poses social, educational and occupational challenges, with affected children being at greater risk of developing behavioral, psychological and emotional problems, lower self-esteem and poorer social integration. The aim of this study was to assess the prevalence and identify the causes of visual impairment and blindness in school children of UC Gojra, Muzaffarabad, Pakistan so that prevention strategies could be implemented.

Methods: This was a school-based descriptive cross-sectional study conducted among public and private schools. A multi-stage stratified random sampling technique was used for selecting study participants aged 5-20 years from 24 schools in Muzaffarabad. The vision of school children was examined for visual acuity using standard Snellen chart. Those participants who had visual acuity of <6/18 in either eye underwent a more detailed ophthalmic examination to diagnose the causes of VI. An exploration of demographic variables was conducted using Chi-square test.  

Results: The mean age of participants was 10±2.83. The prevalence of visual impairment was 19.6% and 2.3% for severe visual impairment. The age group most affected by VI was 11-15 years (74.2%). There were increased chances of developing VI with advancing age of the participants. Males contributed 88.7% of the cases of VI while females contributed only 11.3%. The class category 5-6 had higher percentage of VI cases (32.7%). Public schools contributed 52.8% of the cases of VI while for private schools the corresponding percentage was 47.2%. The leading cause of VI was refractive error (89.3%) followed by amblyopia (5.0%). Other causes of VI included cataract (1.2%), corneal disease (1.8%), strabismus (1.8%) and nystagmus (0.6%).

Conclusions: There is a need to implement school health policy on visual screening prior to admissions in schools and annual eye screening program for early detection and prompt treatment of eye problems among school children in Muzaffarabad.
Good Corporate Governance dan Manajemen Keuangan dalam Ekonomi Syariah
Authors: Manunggal Syafrudin Arif marah
Published: March 2018

The Good Corporate Governance (GCG) facing challenges to Islamic banks nowadays not only in Indonesia but also in the entire world. GCG is necessary to the Islamic banks due to significance of the stakeholders trust towards Islamic banks its self. But in practice, the GCG could serve as an obligatory and formal instrument for delivering transparant public financial reports of the Islamic banks. In avoiding its shortage of application, Islamic finance management gives guide for encountering the formalistic condition of the GCG of the Islamic banks. For the GCG and the Islamic financial management both are very important, this paper discusses a likely convergence between both principle. Finally, the GCG has to be applied by guiding the Islamic financial management. The Islamic financial management is something to do with weather the religious normative assumptions and social economic ones.
Posisi Ushul Fikih dalam Metodologi Ekonomi Islam
Authors: Wahid Wawan Gunawan Abdul
Published: March 2018

Islamic Economics is an entity of thought and practice that currently writhingin Muslim communities. Each entity has certain ideas of its own methodology.So it is with Islamic economics. Since the product of intentional since thebeginning of Islamic economics is different from the conventional economywas certainly one of the distinguishing framework called ushul fiqh. Thispaper presents the position of ushul fiqh methodology of Islamic economics.To confirm the significance of the position shown several such productswhere the Islamic economic jurisprudence fiqh perspective when used as awhole shows a different product than the product of conventional economics.
Komparasi Kinerja Perbankan Syariah dengan Bank Konvensional: Suatu Studi Literatur
Authors: Indriyani Fany
Published: March 2018

This article looks at how the development of Islamic banking performancein recent years when compared with the performance of conventional banks.This article compares the results of several studies that have been conductedon the two types of banking. The previous study using financial ratios to look at the financial performance of banks. Based on some previous research, there are several measuring tool used to view the performance of both Islamic and conventional banking, is to approach CAMELS (Capital, Assets, Management, Earnings, Liquidity and Market Risk Sensitivity). The ratio used in CAMEL ratios include profitability ratios, liquidity risk and credit risk. In general the results obtained from these studies are not found significant differences in the performance of Islamic and conventional banking. As for some of the differences that exist more on smaller credit risk in Islamic banks and the greater liquidity in Islamic banks. This is a good signal for the development of Islamic banking both nationally and internationally.Artikel ini melihat bagaimana perkembangan kinerja perbankan syariah beberapa tahun belakangan ini jika dibandingkan dengan kinerja bank konvensional. Artikel ini membandingkan hasil beberapa penelitian yangtelah dilakukan terhadap kedua jenis perbankan tersebut. Penelitian terdahulumenggunakan beberapa rasio keuangan untuk melihat kinerja keuanganperbankan. Berdasarkan beberapa penelitian terdahulu terdapat beberapaalat ukur yang digunakan untuk melihat kinerja baik perbankan syariah maupun konvensional, yaitu dengan pendekatan CAMELS. Adapun rasio yang digunakan dalam rasio CAMEL meliputi rasio profitability, liquidity risk, dan credit risk. Secara umum hasil yang diperoleh dari beberapa penelitian tersebut adalah tidak ditemukan adanya perbedaan yang signifikan dalam kinerja perbankan syariah maupun konvensional. Adapun beberapa perbedaan yang ada lebih pada risiko kredit yang lebih kecil pada bank syariah dan likuiditas yang lebih besar pada bank syariah. Hal ini merupakan sinyal yang baik bagi perkembangan perbankan syariah baik secara nasional maupun internasional.
Pengaruh Kepemimpinan, Motivasi dan Religiusitas Terhadap Kepuasan Kerja Karyawan pada PT. Unza Vitalis Salatiga
Authors: Baihaqi Ahmad
Published: March 2018

The study examined the influence of leadership, motivation and religiosity on job satisfaction at. Unza Vitalis Salatiga. Regression model of this quantitative research is: Y = -44.504 + 0.290 K + M + 0,270 R 1,070. The research concluded that leadership, motivation, and religiosity positive and significant impact on job satisfaction of employees of PT. Unza Vitalis Salatiga. Leadership, motivation and religiosity simultaneously affect job satisfaction with the positive and significant at PT. Unza Vitalis Salatiga. The most dominant variable in influencing job satisfaction is work motivation.Studi ini meneliti pengaruh kepemimpinan, motivasi kerja dan religiusitasterhadap kepuasan kerja pada PT. Unza Vitalis Salatiga. Model persamaanregresi dari penelitian kuantitatif ini adalah: Y= -44,504 + 0,290 K + 1,070M + 0,270 R. Berdasarkan penelitian disimpulkan bahwa kepemimpinan, motivasi kerja, dan religiusitas berpengaruh positif dan signifikan terhadap kepuasan kerja karyawan PT. Unza Vitalis Salatiga. Kepemimpinan, motivasi kerja dan religiusitas secara simultan mempengaruhi kepuasan kerja dengan positif dan signifikan pada PT. Unza Vitalis Salatiga. Variabel paling dominan dalam mempengaruhi kepuasan kerja adalah motivasi kerja.
Academic degree recognition in a global era: The case of the doctorate of education (EdD) in Israel
Authors: Bamberger Annette
Published: March 2018

The current discussion around recognition of the doctorate of education (EdD) typically focuses on a national context, usually in relation to the PhD; however, relatively little is known about recognition of the EdD degree in countries that do not offer the qualification. As international
cohorts and online delivery of doctoral education grows, it is valuable to understand the recognition of the EdD, particularly in countries that do not currently offer it, and in which policy and legislation may impede its recognition. Using Israel as a case, this study explores EdD recognition
in a country that does not offer the degree and that has a particularly rigid recognition system, likely as a result of a neoliberal experiment with the deregulation of the higher education arena in the 1990s. My investigations indicate three spheres of recognition for the degree: the public,
private and academic spheres. This article outlines these spheres and explores the implications of such a system.
The landscape of professional doctorate provision in English higher education institutions: Inconsistencies, tensions and unsustainability
Authors: Robinson Carol
Published: March 2018

This article reports findings from a recent research project, commissioned by the Higher Education Funding Council for England (HEFCE), which explored the current landscape of professional doctorate (PD) provision in English higher education institutions (HEIs) (Mellors-Bourne et
al., 2016). Given the absence of a clear definition by the Quality Assurance Agency for England of the characteristics that distinguish PDs from practice-based doctorates and the doctor of philosophy, this paper makes a timely contribution through considering the inherent characteristics
of PD programmes. The paper presents an overview of the state of play of PD programmes currently available in HEIs in England, highlighting how the proliferation of PD titles and programmes, and inconsistencies between the various programmes, has resulted in confusion about what PDs are, the
contribution they make, and the value they add to professional practice. Consideration is given to the tensions created through the expansion in the number and types of PDs available, and the implications of these tensions with regard to the future sustainability of PD programmes in general
and in relation to the professional doctorate in education (EdD) in particular.
试论房建施工技术及施工问题
Authors: 陈 瑞
Published: March 2018

本文介绍了房建工程施工中就施工规范、施工技术、施工管理等方面经常出现的问题，提出了解决这些问题的经 验和方法，以保证房屋建筑的质量。
影响建筑工程施工质量的因素与策略研究
Authors: 黄 俊翔
Published: March 2018

建筑工程施工质量直接关系到国家的发展建设以及人们的生命财产安全。本文围绕建筑工程施工进行讨论，介 绍影响建筑工程施工质量的因素，探讨相应的解决对策，希望可以进一步的加强建筑工程的施工质量，推动建筑行业的可 持续发展。
建筑施工中的地基施工技术分析
Authors: 高 旭
Published: March 2018

地基是整个建筑工程施工的重要部分，建筑地基的好坏对建筑实体起着决定性的作用，会影响着整个工程的整 体质量。本文介绍了建筑地基的技术要求、施工特点和施工技术，并详细介绍了CFG 桩、人工成孔灌注桩、振动沉管灌注 桩、旋挖钻孔灌注桩等技术和方法在建筑地基施工中的应用。
计算机系统安全与计算机网络安全
Authors: 季 江
Published: March 2018

本文针对计算机系统安全和计算机网络问题，展开具体剖析，分析了目前信息技术所面临的安全问题和解决安 全漏洞的措施，希望对大家有所裨益。
高职院校工程造价专业BIM技术人才培养探讨
Authors: 梅 燕飞 , 肖 昊
Published: March 2018

BIM 技术人才培养是高职院校工程造价专业教学的发展趋势，其不仅可以提升工程建设项目的控制效果，而且 还能建立体直观的模型展现工程项目的各个阶段。在教学中融合BIM 技术教学可以促使学生提升自身的专业技能及素养， 并且借助BIM 技术可以更好的实施工程造价控制。本文概述了BIM 技术，对高职院校工程造价专业应用BIM 技术教学以 及加强高职院校工程造价专业BIM 技术人才培养的策略进行了探讨分析。