bluuebunny/crossref_metadata_2025 huggingface dataset:
Importance of the Results of VOYAGER PAD Trial for Clinical Practice
Authors: Хрыщанович В.Я.
Published: March 2022

Пациенты с заболеваниями периферических артерий (ЗПА), перенесшие открытые реконструктивные или эндоваскулярные вмешательства, входят в группу повышенного риска ишемических осложнений. В то время как очевидные преимущества интенсификации антитромботической терапии были продемонстрированы после реваскуляризации коронарных артерий при ишемической болезни сердца, указанный подход до недавнего времени не находил достаточных подтверждений у пациентов с ЗПА. Однако результаты исследований ATLAS ACS-TIMI 51 и COMPASS доказали целесообразность применения новой антитромботической стратегии – добавление «сосудистой» дозы ривароксабана к стандартной антитромбоцитарной терапии, что позволило снизить риск ишемических осложнений у пациентов, перенесших острый коронарный синдром, а также в случаях стабильного течения атеросклеротической болезни, в том числе ЗПА. Вместе с тем неизученным оставался вопрос относительно преимуществ такой терапии в популяции пациентов с ЗПА, которые перенесли открытую или эндоваскулярную реваскуляризацию нижних конечностей. В настоящей статье отражены ключевые положения исследования VOYAGER PAD, касающиеся высокой эффективности и приемлемой безопасности ривароксабана в сочетании с аспирином после периферических артериальных реконструктивных вмешательств.

Patients with peripheral artery disease (PAD), who underwent lower extremity revascularization, are at high risk of ischemic events. While intensification of antithrombotic therapy after revascularization has demonstrated the benefit in coronary disease population, this approach has not been well- studied or proven in PAD. Recent ATLAS ACS-TIMI 51 and COMPASS trials proved that the treatment strategy of rivaroxaban added to the background antiplatelet therapy reduced ischemic risk in patients, who had acute coronary syndromes, as well as in patients with stable atherosclerotic vascular disease, including PAD. Whether these benefits extend to the population of patients with symptomatic lower extremity PAD, who undergo revascularization, was the objective of the VOYAGER PAD trial. The final results of the VOYAGER PAD study revealed the effectiveness and acceptable safety of combined antithrombotic therapy after revascularization of peripheral arteries.
Energy Collapse in COVID-19: Diagnostics and Treatment
Authors: Саливончик Д.П. , Саливончик Е.И.
Published: March 2022

Самостоятельным диагностическим критерием для оценки прогноза у пациентов с COVID-19 является динамика уровня лактата, гиперпродукция которого обусловлена кризисом энергопродуцирующих систем и перегрузкой гликолитического пути образования энергии. Единственным корректором энергетического коллапса, вызванного COVID-19, является использование Тиотриазолина – метаболического препарата с множественными путями использования лактата и стимулирования окислительного фосфорилирования, мощными антиоксидантными свойствами. Такие препараты, как блокаторы метаболизма жирных кислот (триметазидин, мельдоний), в данной ситуации не имеют патогенетического и биохимического обоснования.

An independent diagnostic criterion for assessing the prognosis in patients with COVID-19 is the dynamics of lactate level, the overproduction of which is caused by the crisis of energy-producing systems and the overload of the glycolytic pathway of energy production. The only corrector of the energy collapse caused by COVID-19 is the use of thiotriazoline, a metabolic drug with multiple pathways of lactate use and stimulation of oxidative phosphorylation, with powerful antioxidant properties. Such drugs as blockers of fatty acid metabolism (trimetazidine, meldonium) in this situation have no pathogenetic and biochemical substantiation.
On the Issue of Accounting for Lost Temporary Teeth during Epidemiological Dental Examinations of Children during Mixed Dentition Stage
Authors: Попруженко Т.В. , Борис С.П. , Алексанян А.М.
Published: March 2022

Введение. Исследователи заболеваемости кариесом в период смешанного прикуса сталкиваются с трудностями при регистрации отсутствующих временных зубов из-за недостатка информации о причинах их утраты. Известные подходы предполагают сокращенный учет или вовсе игнорируют данные об удалении разрушенных временных зубов.Цель исследования: изучить возможности оценки преждевременной утраты временных моляров c использованием актуальных данных о хронологии смены зубов.Материалы и методы. Проведен сравнительный анализ хронологии утраты временных моляров и прорезывания премоляров у детей (n=1331) в возрасте от 6 до 13 лет, постоянно проживающих в городе или в сельской местности Беларуси.Результаты. Установлены существенные различия в хронологии утраты временных и прорезывания постоянных зубов-сменщиков, варьирующие в подгруппах, составленных по признаку зуба, возраста, места проживания, что может отражать уровень утраты временных моляров вследствие осложнений кариеса при сопутствующих медико-социальных условиях.Выводы. Метод, основанный на анализе хронологии смены зубов и апробированный в применении к временным молярам, прямо отражает актуальный уровень утраты временных зубов и может быть полезен для сравнительной эпидемиологической оценки заболеваемости детей кариесом в период смешанного прикуса.

Introduction. Researchers of caries incidence during the mixed dentition stage have difficulties with registering missing temporary teeth due to a lack of information about the reasons for their loss. Known approaches involve simple accounting or completely ignore information about extraction of damaged teeth. The aim of the research is to study the possibilities of assessment early loss of temporary molars using actual information about chronology of teeth changes.Materials and methods. A comparative analysis of the chronology of temporary molars loss and eruption of premolars in children (n=1331) aged from 6 till 13 years old, permanently living in the city or in the countryside of Belarus, is carried out.Results. Significant differences were found in the chronology of the loss of temporary and eruption of permanent teeth, varying in subgroups composed by sign of tooth, age, and place of living, which may show the level of temporary molars loss due to complications of caries in accordance to accompanying medical and social conditions.Conclusions. The method based on the analysis of the chronology of teeth changes and tested in temporary molars, directly show dependence the current level of loss of temporary teeth and can be useful for a comparative epidemiological assessment of the incidence of caries in children during a mixed bite dentition stage.
The Contents of Glucose in Erythrocytes of Patients with Anemia of Malignant Neoplasm in Urothelial Cancer of the Urinary Bladder
Authors: Борисенко Д.А. , Выдыборец С.В.
Published: March 2022

Цель исследования. Изучение содержания глюкозы в эритроцитах периферической венозной крови пациентов с анемией злокачественного новообразования при уротелиальном раке мочевого пузыря.Методы. Содержание глюкозы в эритроцитах периферической венозной крови определяли по методу Камышникова В.С. (2004).Результаты. Изучены основные показатели содержания глюкозы в эритроцитах периферической венозной крови пациентов с анемией злокачественного новообразования при уротелиальном раке мочевого пузыря. Описаны клинические и лабораторные изменения, представлены принципы дифференциальной диагностики.Заключение. Показатель содержания глюкозы возможно использовать при проведении дифференциальной диагностики железодефицитной анемии и анемии злокачественного новообразования вследствие уротелиального рака мочевого пузыря, поскольку показатели имеют разнонаправленный характер изменений.

Purpose. To study the content of glucose in erythrocytes of peripheral venous blood in patients with anemia of malignant neoplasm in urothelial cancer of the urinary bladder.Methods. The content of glucose in erythrocytes of peripheral venous blood was determined with the method of Kamyshnikov S.V. (2004).Results. There was studied the content of glucose in erythrocytes of peripheral venous blood of patients with anemia of malignant neoplasm due to urothelial cancer of the urinary bladder. Their clinical and laboratory sings and differential diagnostics were described.Conclusion. There was made the conclusion about the importance of the given parameter for laboratory diagnostics of iron deficiency condition and anemia of malignant neoplasms.
Epidemiological Analysis of the Scabies Situation in the Gomel Region
Authors: Островский А.М. , Бубен А.Д. , Кветинский В.А.
Published: March 2022

В настоящей работе представлены основные итоги эпидемиологического анализа ситуации по чесотке в Гомельской области. За 2015–2019 гг. были проанализированы результаты клинико-лабораторного обследования лиц, обратившихся за медицинской помощью в учреждение «Гомельский областной клинический кожно-венерологический диспансер» с диагнозом «чесотка». Имеющиеся данные позволили провести анализ, в каких половозрастных группах имеется снижение заболеваемости, но и ее рост. В результате проведенного исследования было установлено, что распространенность чесотки среди населения Гомельской области имеет четкую тенденцию к снижению, которая может быть обусловлена совершенствованием системы диагностики и лечения данной патологии.

This paper presents the main results of the epidemiological analysis of the scabies situation in the Gomel region. For 2015–2019 the results of clinical and laboratory examination of persons who applied for medical help to the institution“Gomel Regional Clinical Skin and Venereal Diseases” with a diagnosis of scabies were analyzed. The available data allowed us to analyze in which gender and age groups there is a decrease in the incidence, but also its growth. As a result of the study, it was found that the prevalence of scabies among the population of the Gomel region has a clear tendency to decrease, which may be due to the improvement of the system of diagnostics and treatment of this pathology.
Calciphylaxis: a Case from Practice
Authors: Тихоновская И.В. , Лесничая О.В. , Аннаева Н.А. , Ловчиновская Ю.А.
Published: March 2022

Описан случай кальцифилаксии кожи на фоне гемодиализа у пациентки 64 лет с хронической почечной недостаточностью в результате поликистоза почек. Кальцифилаксия развилась после 9 лет гемодиализа. Предшествующие клинические проявления в виде доброкачественной узловатой кальцификации сочетались с язвой первого пальца правой стопы на фоне атеросклероза. Лабораторные данные: индекс массы тела – 25,7, гликированный гемоглобин – 6,5%, паратгормон – более 1053,0 пг/мл, калий – 4,6 ммоль/л, натрий – 145 ммоль/л, кальций – 2,7 моль/л, фосфор – 2,6 моль/л, креатинин – 675 мкмоль/л, мочевина – 18,6 ммоль/л, мочевая кислота – 400 ммоль/л (11.10.18), ЦИК – 102 ед., МНО – 1,07, фиброген – 4,8, тромбиновое время – 15,6, ПТИ – 0,92%; анти-ДНК антитела (16.11.18) – не обнаружены.Заключение. Кальцифилаксия/кальцификация должна подозреваться у пациентов группы риска независимо от сопутствующей патологии, приводящей к формированию узлов, язв и некрозов.

A case of calcifylaxis of the skin in a 64-year-old hemodialysis patient with chronic renal failure as a result of kidney polycystic disease was described. Calciphylaxis developed after nine years of hemodialysis. Previous clinical manifestations in the form of benign nodular calcification were combined with an ulcer of right foot first finger and atherosclerosis.Laboratory examination: body mass index – 25.7, glycated hemoglobin – 6.5%, parathyroid hormone – more than 1053.0 pg/ml; K – 4.6 mmol/l, Na – 145 mmol/l, Ca – 2.7 mol/l, P– 2.6 mol/l, creatinine – 675 mmol/l, urea – 18.6 mmol/l, uric acid – 400 mmol/l (11.10.18), CIC – 102 units, INR – 1.07, fibrinogen – 4.8, thrombin time – 15.6, PTI – 0.92%; anti-DNA antibodies (16.11.18) – negative. Conclusion. Calcifylaxis/calcification should be suspected in the group risk patients despite present pathology that leads of nodes, ulcers and necrosis.
Modern Possibilities of Correction of Microbiome Disorders in Children. The Role of Bifidobacterium Animalis Subspecies Lactis BB-12® from the Standpoint of Evidence-Based Medicine
Authors: Бекетова Г.В. , Солдатова О.В.
Published: March 2022

В статье представлены данные о современном определении микробиома и его роли как важного фактора, определяющего здоровье человека. Акцентировано внимание на свойствах кишечной микробиоты, которая принимает участие в переваривании и всасывании микро- и макронутриентов, иммунных реакциях, препятствует размножению патогенных бактерий, а также влияет на перистальтику кишечника, созревание энтеральной нервной системы и головного мозга. Изменения микробиома признаны одной из причин развития многих заболеваний – антибиотикассоциированной диареи, Clostridium difficile инфекции, синдрома раздраженного кишечника, воспалительных заболеваний кишечника, колоректального рака, атопии, муковисцидоза, бронхиальной астмы. Авторы описывают роль пробиотического микроорганизма Bifidobacterium animalis subspecies lactis BB-12® в лечении и профилактике заболеваний, связанных с нарушением микробиома у детей. Представлены данные о положительных эффектах штамма ВВ-12® в лечении и профилактике диареи (в том числе антибиотикассоциированной), младенческих колик, рекуррентных респираторных заболеваний, атопического дерматита.

The article presents modern views on the role of the microbiome as an important factor in determining human health. A special role belongs to the intestinal microbiome, which takes part in the digestion and absorption of micro- and macronutrients, immune reactions, prevents the reproduction of pathogenic bacteria, and also affects intestinal motility and the maturation of the enteric nervous system and brain. One of the causes of many diseases is a change in the composition of the microbiome (antibiotic-associated diarrhea, Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel disease, colorectal cancer, atopy, cystic fibrosis, bronchial asthma). The authors describe the role of the probiotic Bifidobacterium animalis subspecies lactis BB-12® in the treatment and prevention of diseases associated with disruption of the microbiome in children. The positive effects of BB-12® in the treatment and prevention of diarrhea (including antibiotic- associated one), infant colic, recurrent respiratory diseases, and atopic dermatitis are described.
Magnesium-Containing Medicines: from Clinical Pharmacology to Pharmaceutical Assistance (Part 1)
Authors: Кирилюк А.А.
Published: March 2022

Магний является незаменимым катионом организма человека и содержится преимущественно в костях, мышцах и мягких тканях. Магнийсодержащие лекарственные препараты назначаются с учетом клинических и лабораторно-диагностических показателей. В статье уделено внимание биологической роли магния и связанным с ним фармакодинамическим эффектам лекарственных препаратов. Систематизирована информация по показаниям к применению и противопоказаниям, нежелательным реакциям и лекарственным взаимодействиям с позиции причинно-следственных связей, опирающихся на биохимические, фармакодинамические и фармакокинетические особенности соединений магния. Установлено, что соли магния обладают низкой биодоступностью (и зависят от типа соли), всасываются в тонком кишечнике двумя транспортными путями (параклеточный и трансклеточный), а почки оказывают важную роль в поддержании гомеостаза магния.

Magnesium is an irreplaceable cation of the human body and it is found mainly in bones, muscles and soft tissues. Magnesium-containing medicines are prescribed on the base of clinical and laboratory diagnostic parameters. The article is focused on the biological role of magnesium and the associated pharmacodynamic effects of medicines. Actual and systematic information about medical use and contraindications, adverse reactions and drug interactions was systematized according to pharmacodynamics and pharmacokinetics of magnesium compounds and cause- effect relationships. It is discovered that magnesium salts have low bioavailability (and depend on the type of salt); they are absorbed in the small intestine by two transport pathways (paracellular and transcellular), and kidneys play an important role in maintaining the magnesium homeostasis.
Postcovid Syndrome
Authors: Авдей Г.М.
Published: March 2022

Представлен обзор по коронавирусной инфекции с описанием клинических проявлений и лечения постковидного синдрома. Сделано предположение о возможности применения кавинтона ввиду его широкого спектра фармакологического действия при постковидном синдроме.

An overview of the coronavirus infection is presented. Clinical manifestations of the postcovid syndrome are presented. An assumption was made about the possibility of using cavinton due to its wide spectrum of pharmacological action in postcovid syndrome.
The Role of Endothelial Factors and Interleukins in the Formation of Various Degrees of Severity of the Inflammatory Processin Children with Focal, Segmental and Lobar Pneumonia
Authors: Парфёнова И.В. , Максимович Н.А.
Published: March 2022

Цель. Установить роль интерлейкинов и эндотелиальных факторов в формировании различной степени выраженности воспалительного процесса у детей с острой внегоспитальной пневмонией.Материалы и методы. Обследовано 100 пациентов с острой внегоспитальной пневмонией с (n=70) и без (n=30) дисфункции эндотелия. Проанализированы показатели, характеризующие продукцию IL-1β, TNF-α и состояние эндотелий-зависимой дилатации сосудов у детей с острой пневмонией.Результаты. Установлено, что у детей с острыми внегоспитальными пневмониями с дисфункцией эндотелия уровень цитокинов был значительно выше, чем у детей без дисфункции эндотелия (p<0,001). Клинический анализ показал, что у пациентов без дисфункции эндотелия преобладали очаговые пневмонии, а с дисфункцией эндотелия – сегментарные и долевые пневмонии.Выводы. Полученные данные свидетельствуют о сниженных компенсаторных реакциях системного кровотока в легочной ткани у пациентов со сниженной эндотелий-зависимой вазодилатацией. Установленные в работе закономерности, характеризующие степень повышения уровня цитокинов и снижения эндотелий-зависимой дилатации сосудов, могут быть использованы для прогноза течения острых внегоспитальных пневмоний.

Purpose. To reveal the role of interleukins and endothelial factors in the formation of various degrees of severity of the inflammatory process in children with acute pneumonia.Materials and methods. 100 patients with acute pneumonia with (n=70) and without (n=30) endothelial dysfunction were examined. We analyzed the indicators that characterize the production of IL-1β, TNF-α and the state of endothelium-dependent vascular dilation in children with acute pneumonia.Results. It was found that children with acute pneumonia with endothelial dysfunction had significantly higher cytokine levels than children without endothelial dysfunction (p<0.001). Clinical analysis showed that focal pneumonia prevailed in patients without endothelial dysfunction, and segmental and lobar pneumonia prevailed in patients with endothelial dysfunction.Conclusions. The obtained data indicate the reduced compensatory reactions of systemic blood flow in the lung tissue in patients with reduced endothelium-dependent vasodilation. The regularities revealed in the work that characterize the degree of cytokine level increase and decrease of endothelium-dependent vascular dilatation can be used to predict the course of acute pneumonia.
Analisis Kemampuan Literasi Matematis Siswa SMP Pada Materi Bangun Datar
Authors: Lestari Risna Dwi , Effendi Kiki Nia Sania
Published: March 2022

Penelitian ini bertujuan untuk mendeskripsikan kemampuan literasi matematis siswa ditingkat SMP dalam menyelesaikan soal pada materi bangun datar yaitu Segitiga dan Segiempat. Penelitian ini dilakukan pada siswa kelas VIII di MTS Al-Hikmah Johar Karawang dengan subjek penelitian sebanyak 15 siswa. Pendekatan yang digunakan pada penelitian ini adalah pendekatan kualitatif dengan metode deskriptif. Teknik pengumpulan data menggunakan tes literasi matematis yang berupa soal uraian dengan materi segitiga dan segiempat. Terdapat indikator kemampuan literasi matematis yang digunakan dalam penelitian ini, yaitu: 1) Memformulasikan situasi nyata secara matematis, 2) Menerapkan konsep matematika, serta 3) Mengevaluasi hasil matematika. Hasil penelitian menunjukkan dari 4 soal literasi matematis yang diberikan, diperoleh bahwa pada soal nomor satu terdapat 1 siswa yang mampu memenuhi indikator literasi matematis, serta pada soal nomor 2, 3 dan 4 tidak ada siswa yang mampu memenuhi indikator literasi matematis. Hal ini disebabkan karena siswa kesulitan dalam mengkomunikasikan jawabannya secara tertulis. Selain itu, siswa tidak mengevaluasi jawabannya terlebih dahulu, hal ini dikarenakan siswa ingin cepat selesai dalam mengerjakan soal.
Peningkatan kepadatan Alona sp. pada jerami padi yang difermentasi
Authors: Utami Tiara , Pangkey Henneke , Lantu Sartje , Lumenta Cyska , Salindeho Indra R. N. , Kemer Kurniati
Published: March 2022

The objective of this study was to determine the difference in density of Alona sp in fermented rice straw and unfermented rice straw media. This research was conducted at the Aquaculture Technology Laboratory and the Fish Health, Environment and Toxicology Laboratory, Faculty of Fisheries and Marine Sciences, Sam Ratulangi University, Manado, from March to June 2021.The experiment was based on four treatments, namely fermented rice straw media with Effective Microorganisms-4 (EM-4) solution, unfermented rice straw media, horse manure media and water media. The experimental design used was a completely randomized design (CRD) with 4 treatments, each treatment was repeated 3 times, so there were 12 experimental units. The results obtained are the density of Alona sp. cultured on fermented rice straw media were not significantly different from those cultured on unfermented rice straw media but significantly different from horse manure and water media. There was no significant difference between fermented straw media and unfermented straw media on the increase in density of Alona sp., apparently caused by the fermentation time of EM-4 solution of rice straw which was not long enough.
Uji efektivitas senyawa antibakteri penyebab ice-ice dari daun ketapang Terminalia catappa L. dengan metode ekstraksi berbeda
Authors: Sinaga Chintya R. , Kreckhoff Reni L. , Salindeho Indra R. N. , Ngangi Edwin L. A. , Mudeng Joppy D. , Rompas Rizald M.
Published: March 2022

This study aimed to find out the right extraction method to produce ketapang leaf extract with best phytochemical content and best inhibition ability against ice-ice causing bacteria. The experiment was conducted at the Laboratory of Fish Health, Environmental and Toxicology, from April to June, 2021. The experiment was designed according to a Completely Randomized Design (CRD) with 5 treatments and 3 replications. The three main treatments were, treatment A: extraction of ketapang leaves Terminalia catappa L. with 95% ethanol (extract A), treatment B: extraction of ketapang leaves T. catappa L. with 40°C water (extract B), and treatment C, extraction of ketapang leaves T. catappa L. with distilled water (extract C).  In the inhibition ability test, each extract obtained from the three main treatments was compared with two controls namely treatment D: positive control (Kanamicyn) and treatment E: negative control (aquadest). The phytochemical content data was analyzed descriptively, while the bacterial inhibition zone diameter data was statistically analyzed with Anova and LSD. The phytochemical analysis result showed that, the extract A contains alkaloids, flavonoids, triterpenoids and tannins,  while extract B and extract C contain alkaloid, saponin and tannin. The inhibition ability test showed that extract A gave the strongest inhibition (14.87 mm) against the ice-ice causing bacteria, and was significantly different from that of extract B (5.23 mm) and C (2.47 mm).  The inhibition ability of extract B was significantly different from that of extract C. The inhibition ability of the three ketapang leaf extracts (A, B and C) against the ice-ice causing bacteria was much weaker and significantly different from that of Kanamicyn (positive control).
Studi fisika kimia perairan untuk budidaya ikan nila (Oreochromis niloticus) yang dipelihara pada keramba jaring apung di Desa Pematang Limau
Authors: Lastari Linda , Handayani Leni
Published: March 2022

This study aimed to determine the water quality in the floating net cage area in the cultivation of tilapia (Oreochromis nilocitus) and to find out how the condition of the waters in Pematang Limau could support the cultivation activities.  This research was conducted using 3 (three) stations. Water quality data collection was carried out 3 times. The data used included primary and secondary data. Parameters observed in situ included temperature, brightness, current velocity and pH. Ammonia, DO and BOD were analyzed at the Calibration and Health Laboratory of Central Kalimantan in Palangka Raya. Research resulted showed that the overall water quality in the floating net cage area can still be used to maintain tilapia culture. The water quality at each station showed a value that can still be used for cultivation activities except for BOD value that was high.
Penggunaan ekstrak Ciplukan (Physalis angulata) untuk memacu pertumbuhan ikan Nila (Oreochromis niloticus)
Authors: Maweikere Fabiola C. , Tumbol Reiny A. , Monijung Revol D. , Manoppo Henky , Kreckhoff Reni L. , Darwisito Suria
Published: March 2022

This study aimed to examine the effect of adding ciplukan (Physalis angulata) to feed on the growth of tilapia and to find a dose of ciplukan that was able to increase the growth of tilapia (Oreochromis niloticus). The test fish used were tilapia with an average size of 5-8 cm as many as 300 fish from the Center for Freshwater Aquaculture (BPBAT), Talelu. This research was conducted at the Aquaculture Technology Laboratory, Faculty of Fisheries and Marine Sciences, Sam Ratulangi University. This study used a completely randomized design (CRD) with 4 treatments, where each treatment had 3 replications so there were 15 experimental units, the treatment used was ciplukan flour with different concentrations consisting of: A: 0 g flour/kg feed, B : 10 g flour/ kg feed, C : 15 g flour/ kg feed, D : 20 g flour/ kg feed. The data collected consisted of fish weight to measure the fish growth. The results showed that the addition of ciplukan leaf extract in feed with different concentrations gave significantly different effects on the growth of tilapia with treatment B (10 g) showing the highest fish growth reaching 5.24 g, followed by treatment C (15 g) with the highest growth. reached 4.35 g. While the fish treated with D (20 g) only reached 3.16 g in weight where this value was not much different from the growth of fish in control A. Duncan's further test results showed that treatments B, C, D were not significantly different from each other, but these three treatments were very significantly different compared to fish that were not given ciplukan leaf extract. The study showed that ciplukan leaf extract added to feed gave significantly different effects on fish growth, with the best dose of 10 g extract/kg feed. Thus it can be concluded that ciplukan leaf extract can increase growth of Nile tilapia.
Tingkat kelangsungan hidup Trepang Benang (Bohadschia marmorta) dengan metode transverse-fission di perairan alam dan pada wadah terkontrol
Authors: Rondonuwu Yonatan Y. , Sambali Hariyani , Sinjal Hengky J. , Kusen Diane J. , Kalesaran Ockstan Y. , Pratasik Silvester B.
Published: March 2022

This research was conducted to examine the survival and regeneration success rate of the Brown Sandfish (Bohadchia marmorata) using the Transverse-fission method in containers placed in nature and controlled. This research was conducted  from June to July 2021, in Bahoi Village, West Likupang, North Minahasa. This research used the Transverse-fission method, in which B. marmorata was tied using a rubber band until cleavage occurred. The container used is a basket covered with a net as many as 6 units, each of which is insulated in the middle so that it becomes 12 parts. Individuals who have been tied, then observed for changes shortly after the binding is done until the individual is separated (every 1 - 2 hours), followed by observing the survival and regeneration of separate body parts (every 6 hours). The results of the study were then analyzed using SPSS 22 version with T-test.  Based on the results of the research, the survival and regeneration success rate of B. marmorata using the Transverse-fission method placed in containers in natural waters was significantly different from that of B. marmorata placed in controlled containers, where the total survival rate of B. marmorata placed in in controlled containers reached 100% while the total survival rate of B. marmorata placed in natural waters only reached 3.33%.
Kelayakan lokasi budidaya ikan Kuwe (Caranx sp.) ditinjau dari parameter fisika kimia kualitas air pada karamba jaring apung di Desa Tuntung Timur Kabupaten Bolaang Mongondow Utara
Authors: Datunsolang Frayogi , Kusen Diane , Kalesaran Ockstan J. , Undap Suzanne L. , Sambali Hariyani , Wantasen Adnan S. , Salindeho Indra
Published: March 2022

This study aimed: (1) to analyze the physical and chemical parameters of water quality of the giant travelly fish (Caranx sp) culture area in floating net cages (KJA) in Tuntung Timur Village, Bolaang Mongondow Utara Regency, and (2) to analyze the feasibility of water quality of the giant travelly fish (Caranx sp) in east Tuntung Village, North Bolaang Mongondow Regency. The  physical and chemical parameters of water at the cultivation site of Caranx sp in floating net cages were measured in situ, including temperature, salinity, brightness, dissolved oxygen and pH. Chemical physics parameters in floating net cages, namely: temperature ranges from 28.6 oC - 33.3 oC, salinity 30 - 33 0/oo, pH 7.6 - 7.9, oxygen content 3, 9 - 4.3 mg / l and water transparency of 7.4 m - 9.9 m. The giant travelly fish aquaculture in KJA in east Tuntung village is an enlargement activity, the seeds were stocked from bagan and the surrounding waters, the size of the seeds ranged from 8-12 cm, and the stocking density was 500-600 fish. Maintenance was carried out for 5-6 months and harvested at sizes 300-4000 gr/individu. The water quality surrounding KJA was ideal for fish farming activities.
Kultur pakan alami Alona sp. dalam media daun eceng gondok yang difermentasi dengan larutan Effective Microorganisme-4
Authors: Sumah Maria , Solang Jhonly , Pangkey Henneke , Mokolensang Jeffrie F. , Lumenta Cyska , Sinjal Hengky Sinjal , Rumampuk Natalie D. C.
Published: March 2022

The purpose of this study was to examine the density of life feed Alona sp. on the media of water hyacinth leaf fermented with effective microorganism-4 (EM-4) solution. The method used was an experimental, using one-way ANOVA, with four treatments, namely fermented water hyacinth leaf media, unfermented water hyacinth leaf media, horse manure media, and water, each with three replications. The parameter observed was the density of Alona sp. The result showed that the density of Alona sp. cultured using fermented water hyacinth leaf media was significantly different from those cultured on unfermented water hyacinth leaf media.  It had also been found that the density of Alona sp. high in horse manure media. However, it is recommended to use fermented water hyacinth leaf media, because it is more hygienic. In addition, the availability of horse manure is increasingly rare
Concepções e práticas de professores do município de Moju/Pará a respeito do ensino de geometria e construções geométricas
Authors: Silva José Augusto Lopes da
Published: March 2022

O ensino da geometria é marcado pela influência direta de um contexto histórico de desvalorização da área, que atinge ainda hoje os conjuntos de práticas metodológicas e consequentemente os processos de ensino e aprendizagem. Diante desta realidade, tal pesquisa procura compreender as concepções e práticas de professores de matemática relacionadas à geometria e ao trabalho com metodologias de ensino atreladas ao contexto das construções geométricas. Para tanto foi realizada uma pesquisa bibliográfica, apoiada em estudos como os de Perez (1991), Pavanello (1993), Lorenzato (1995), Gazire (2000) e Fonseca et al. (2001), por exemplo, e uma pesquisa de campo, com a participação voluntária de seis professores de matemática dos anos finais do Ensino Fundamental, atuantes no município de Moju/Pará. Os dados foram coletados ao longo do segundo semestre de 2019, com a realização de entrevistas e aplicação de questionários semiabertos, envolvendo questões relacionadas ao ensino da geometria, à adoção de metodologias de ensino e a utilização das construções geométricas. Verifica-se que as construções geométricas não são completamente exploradas no ensino da geometria, embora haja um planejamento inicial que indique a construção de formas geométricas básicas, elas são por vezes omitidas em função do tempo ou do ensino prioritário de outros conteúdos como da aritmética, por exemplo, considerados mais importantes por parte dos professores pesquisados, no contexto do currículo que deve ser efetivamente cumprido em sala de aula.
Penentuan Pemberian Bantuan Smart Fishing Kepada Nelayan Menggunakan Metode SMART
Authors: Nuris Nisa Dienwati
Published: March 2022

Abstract- Fisheries development as part of national economic development has the aim, among others, to improve the standard of living and welfare of the fishing community. The effort to realize the Champion fisherman and Fish Warehouse program to encourage fish production in the West Java provincial government of West Jawa through the Department of Marine Affairs and Fisheries seeks to develop fishery potential through the SMART FISHING assistance program. So that the aid program is properly, an application is made to determine the fisherman who are entitled to receive assistance. The purpose of this study is producing a SAFIA application using the SIMPLE MULTI ATTRIBUTE RATING TECHNIQUE method based on a web framework that can facilitate the Department of Marine Affairs and Fisheries of West Java to determine the best group of fisherman according to the criteria for receiving assistance. The Result of making this research is how the SAFIA application works with accuracy
Sistem Rekomendasi Pemilihan Buku Menggunakan Algoritma Collaborative Filtering pada Perpustakaan Universitas Muhammadiyah Sukabumi
Authors: Putri Ergina Kamilia
Published: March 2022

Abstract- The book is a reference because it has a function, it is available in the library so that it can be used by everyone. Almost every book is in the library, it's just that some people are still confused in choosing what books to read. Therefore, a book recommendation system was created, especially now that almost every library system runs online. With the recommendation system, library users can read books according to the recommendations that have been given. The purpose of this study was to create a book recommendation system at the Muhammadiyah University of Sukabumi library and to see the value of accuracy in making a recommendation system. The method used in this research is using the Collaborative Filtering method, with various calculations from finding the similarity, predictive value to the accuracy value of the recommendations obtained. Based on the results of the research that has been done, it shows that Collaborative Filtering produces an accuracy value of 93%, which means that the recommendation system with this method has very good accuracy results. Abstrak- Buku merupakan sebuah referensi karena memiliki fungsi, tersedia di dalam perpustakaan sehingga dapat dipakai oleh semua orang. Hampir setiap buku ada di dalam perpustakaan hanya saja beberapa orang masih kebingungan dalam pemilihan buku apa yang harus dibaca. Maka dari itu dibuat sebuah sistem rekomendasi buku terutama saat ini hampir setiap sistem perpustakaan berjalan secara online. Dengan adanya sistem rekomendasi, para pengguna perpustakaan dapat membaca buku sesuai dengan hasil rekomendasi yang telah diberikan. Tujuan dari penelitian ini untuk membuat sistem rekomendasi buku pada perpustakaan Universitas Muhammadiyah Sukabumi dan melihat nilai akurasi dalam pembuatan sistem rekomendasi. Metode yang digunakan pada penelitian ini yaitu menggunakan metode Collaborative Filtering, dengan adanya berbagai perhitungan dari pencarian nilai kemiripan ataupun similarity, nilai prediksi hingga ke nilai akurasi dari hasil rekomendasi yang didapatkan. Berdasarkan hasil penelitian yang telah dilakukan, menunjukkan bahwa Collaborative Filtering menghasilkan nilai akurasi 93% yang artinya sistem rekomendasi dengan metode ini sangat baik hasil akurasinya.
Perancangan Sistem Informasi Integrated Payment (iPayment) Menggunakan Metode Scrum
Authors: Riana Eri
Published: March 2022

Perkembangan ilmu pengetahuan dan teknologi telah membawa kita pada suatu lembaran baru jaman. Komunikasi dan informasi merupakan salah satu bidang yang terkena imbas manfaat dari perkembangan tersebut. Pergerakan arus informasi dewasa ini berlangsung secara cepat, setiap khalayak kini  mampu  mengakses  informasi  kapan  pun  dan  dimana  pun.  Hal  tersebut menuntut kita bekerja lebih keras dalam mendaya-gunakan segala manfaat dari perkembangan teknologi informasi untuk mencapai kinerja efisien, efektif, dan optimal. Untuk mendukung hal tersebut, salah satu tahapan yang harus dimiliki oleh suatu perusahaan adalah kemampuan pengelolaan sistem informasi data secara aktual dan berkesinambungan yang pada saat ini masih kurang optimal. Tujuan dalam penulisan jurnal ini adalah untuk membuat suatu sistem payment yang terintegrasi satu sama lainnya dengan menggunakan Agile software development yaitu metode Scrum. Proses pengembangan sistem ini menggunakan tahapan pengembangan User Stories, Product Backlog, Sprint Backlog, Sprint, Review Demo Product, Delivery Product. Dari hasil pengembangan sistem iPayment ini diharapkan mencapai hasil optimal selama kegiatan operasional.
Penerapan Augmented Reality berbasis Android sebagai Media Promosi di Toko Furniture Jery Meubel
Authors: Arifin Rita Wahyuni , Anwariya Shilka Dina
Published: March 2022

Perkembangan teknologi pada seluruh bidang sangat pesat, bahkan saat ini kita dihadapkan pada fenomena Revolusi Industri 4.0, yaitu pemanfaatan teknologi informasi yang . Dampak dari fenomena Revolusi Industri 4.0 dirasakan oleh berbagai sektor bidang tanpa terkecuali Toko Meubel Jerry Bogor. Kendala yang dialami oleh Toko Meubel adalah kegiatan promosi produk furniture dengan cara memberikan katalog, brosur dan majalah yang menampilkan gambar produk dalam bentuk dua dimensi dengan alasan ekonomis, mengakibatkan konsumen menjadi tidak puas dan tidak bisa melihat kondisi produk secara keseluruhan serta mengharuskan konsumen datang ke toko jika ingin membeli produk. Untuk dapat beradaptasi dan bertahan dalam menghadapi fenomena Revolusi Industri 4.0 maka Toko Meubel Jerry mencoba untuk menerapkan teknologi Augmented Reality (AR) sebagai sarana pemasaran yang lebih interaktif, inovatif dan komunikatif, hal ini sebagai solusi dari permasalahan yang dihadapi oleh Toko Meubel Jery. Metode pengembangan yang digunakan adalah Metode Multimedia Development Life Cycle model Luther, tahapan dalam model ini terdiri dari concept, design, material collecting, assembly, testing dan distribution. Dalam penelitian ini penulis membuat aplikasi media promosi dengan teknologi Augmented Reality dan buku marker untuk menampilkan produk secara tiga dimensi sehingga konsumen puas karena dapat melihat produk secara keseluruhan.
Peningkatan Keamanan Aplikasi Web Menggunakan Web Application Firewall (WAF) Pada Sistem Informasi Manajemen Kampus Terintegrasi
Authors: Rizal Randi , Sumaryana Yusuf
Published: March 2022

Increasing the security of web applications on the integrated campus management information system needs to be done because the application is accessed by public networks so that there are many attacks and attempts to prevent threats from attackers. This study applies a Web Application Firewall (WAF)-based application security using ModeSecurity and Core Rules Set from Owasp which aims to improve the security system of the web application by using a firewall. This study uses an experimental method by implementing a Web Application Firewall (WAF) as a web-based protection system, then the process of analysis and testing to obtain accurate advice on firewall implementation. The results of this study indicate that the firewall used with Web Application Firewall (WAF)-based ModeSecurity has succeeded in stopping attacks from attackers using Cross Site Scripting (XSS) and SQL Injection methods.
PATTERNS OF USING GARLIC AS A TRADITIONAL MEDICINE IN HELPING TREAT THE FLU IN SUMUR VILLAGE
Authors: Indriana Meutia , Salman Salman
Published: March 2022

The purpose of this study was to determine the pattern of use of garlic in the Sumur Village community and know the effectiveness of garlic as a traditional medicine in helping treat flu: non-experimental/observational research. Data analysis used a descriptive cross-sectional design by measuring LL The use of garlic in treating flu. The study was carried out from July 25 to September 12. This study indicates that the people in Sumur Village are still inseparable from their traditions, including very traditional methods of treating flu. Garlic contains sulfur which gives it a distinctive smell and taste that can increase and speed up the activity of the mucous membranes in the respiratory tract. Garlic is better and safer if before. In consumption, garlic is burned or heated first because the nutritious sulfur content has been released and the ester and protein bonds are in this situation, it will be more practical, and garlic which can disrupt the stomach atmosphere, will be safer for garlic users who have a history of ulcers. Garlic contains essential sulfur compounds and 17 amino acids, including eight amino acids and minerals such as calcium, iron, potassium, germanium, selenium, and zinc. One of these sulfur compounds is Alliin. Alliin is easy to turn into Allicin when fresh garlic is chopped, chopped, or chewed directly. The conversion of Alliin to Allicin is assisted by a particular enzyme called allinase. Allicin has the potential as an anti-bacterial; the workings of Allicin are similar to penicillin antibiotics and their derivatives, for example, Amoxicillin: The way it works is by inhibiting the formation of proteins in the bacterial cell wall so that later it can cause defects in the bacterial cell wall which eventually makes the bacteria die because its metabolic system is disrupted. However, one thing to note is that sprouted garlic is not suitable for consumption because the shoots contain the poison HCN (cyanide).
DETERMINATION OF PARACETAMOL LEVELS IN TABLETS AND ORAL SOLUTIONS BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)
Authors: Salman Salman , Indriana Meutia
Published: March 2022

According to RI Law no. 36 of 2009, determining the level of efficacious substances from a drug preparation is one of the requirements that must be carried out to ensure the quality of the drug preparation. Drug preparations of good quality will provide the expected effect and one of the parameters is the level of the active substance of the drug must meet the level requirements listed in the Indonesian Pharmacopeia or other standard books. The purpose of this study was to determine the levels of Paracetamol in tablet preparations and oral solution by high-performance liquid chromatography. The determination of the concentration was carried out by the HPLC method using a 2.5 mm x 25 cm VP-ODS shim pack column with water-methanol as a mobile phase (3:1), a flow rate of approximately 1.5 ml/minute, and the detection was carried out at a wavelength of 243 nm. The advantage of the HPLC method is the separation system with high speed and efficiency because it is supported by advances in column technology, high-pressure pump systems, and highly sensitive and diverse detectors so that they are able to analyze various samples qualitatively and quantitatively, back in single or mixed components. The results showed that all the specified samples met the content requirements according to the Indonesian Pharmacopeia IV edition 1995, namely not less than 90.0% and not more than 110.0% of the amount stated on the label. The results of the Validation test method carried out obtained a recovery percent of 99.96% with an RSD (Relative Standard Deviation) of 1.81% so that it can be concluded that this method has good sensitivity and accuracy, with a LOD (limit of detection) 0.76 g/ml and LOQ (limit of quantitation) 2.56 g/ml.
UTILIZATION OF NEMBA STEM AS AN ANTITUBERCULOSIS COMPARED WITH RIFAMPICIN AND ETAMBUTOL
Authors: Indriana Meutia , Salman Salman
Published: March 2022

Indonesia ranks third in the number of tuberculosis, after India and China. Treatment of tuberculosis takes a long time, and the lack of discipline in taking medication has caused the Mycobacterium tuberculosis to be resistant to many synthetic drugs that have been used so far. In contrast, the discovery of new synthetic drugs is very slow. Traditionally, neem bark (Azadirachta indica JUSS.) has been used to treat coughing up blood and phlegm, and the results of previous studies show that ethanol extract of neem bark in vitro can inhibit the growth of Mycobacterium tuberculosis. This study was conducted to determine the toxicity of neem bark extract, formulation of neem bark ethanol extract into tablet preparations, and the potential of this tablet preparation as anti-tuberculosis in vivo in animals. Neem bark extract was made by percolation using an ethanol extractor. Toxicity test was carried out in the form of an acute toxicity test on mice to calculate the LD50 value and histopathological observations of the liver, lungs, and intestines. The tablets were made by wet granulation. The potential test of tablet preparations as anti-tuberculosis was performed in vivo on animals infected with Mycobacterium tuberculosis H37Rv using a nebulizer. The results showed LD 50 = 11.85 ± 0.571, including mild toxic. The ethanolic extract of neem bark can be formulated into tablets using a 6% gelatin binder, Manihot starch and primojel as a binder, and a mixture of starch and lactose as a filler. Neem bark extract tablets can cure tuberculosis of experimental animals that have been infected with Mycobacterium tuberculosis H37RV, which is given a dose of 3 times a day two tablets (50 mg/tablet) for six weeks seen tuberculosis bacteria from +3 to negative, and a dose of 3 times a day once a day. Tablet looks from +3 to +1.
A AUTONOMIA DA OFICINA TERAPÊUTICA COMO POTENCIALIZADOR NO GRUPO DE SAÚDE MENTAL: RELATO DE EXPERIÊNCIA
Authors: Queiroz Renan Teixeira , Freitas Adrielle Cristina Silva de , Leal Isabelle Tavares , Leitão Leonardo Abreu Carmona , Paiva Matheus de Almeida , Tavares Caroline de Souza , Gomes Bárbara Guerreiro Américo , Dias Biatriz Araújo Cardoso
Published: March 2022

Introdução: A eclosão da Reforma Psiquiátrica Brasileira, em meados dos anos 70, trouxe à tona demandas de saúde no mínimo preocupantes em relação aos pacientes mentais, sobretudo à abordagem pelo Sistema Único de Saúde (SUS), a qual inexistia ou era extremamente insuficiente. Apenas com a institucionalização da Lei nº10.216, as bases comunitárias, como Unidades Básicas de Saúde, puderam ser utilizadas para prover tratamentos que se tornam aliados imprescindíveis à terapêutica medicamentosa e ao cotidiano conturbado desses indivíduos. Objetivo: relatar experiência vivenciada em uma oficina terapêutica como potencializador no grupo de saúde mental. Métodos: A análise de conteúdo ocorreu em bases de dados como Biblioteca Virtual da Saúde (BVS), PubMed e Scielo, com publicações do período de 2016-2021, e a execução da dinâmica ocorreu com 10 participantes. Resultados: Foi evidenciado a relevância do desempenho das atividades grupais, e a expressão social como forma de reinserção dos pacientes mentais ao convívio em sociedade. Conclusão: A realização de práticas integrativas em saúde primária, como as oficinas, mostra-se como elementos de humanização, peça chave na reabilitação psicossocial e de convívio social dos usuários pertencentes aos programas em saúde mental.