bluuebunny/crossref_metadata_2025 huggingface dataset:
Thiazolyl-Thiazolidinone Conjugated Pyrazoles as Potential Anticancer and Antibacterial Agents and Molecular Docking Studies
Authors: Honavar Premanand M. , Kalal Bhuvanesh Sukhlal , Raj Ranjith , Anjana P.T. , Deepthi P.V. , Chandra Sharatha , Vijesh A.M. , Ramu Ramith , Pai Vinitha Ramanatha , Kumar Naveen , Kumar Vasantha , Holla B. Shivarama
Published: November 2024

In current study, five new compounds containing thiazolyl-thiazolidinone conjugated substituted pyrazoles were prepared and screened for anticancer and antimicrobial activities. Synthesized compounds were characterized by spectroscopic techniques. Anticancer activity was carried out against human melanoma cancer A375 and human breast cancer MDA-MB-231 cell lines. Also, these were screened for antibacterial activity against two Gram-positive Staphylococcus aureus, Bacillus subtilis strains and three Gram-negative Pseudomonas aeruginosa, Klebsiella pneumonia and Escherichia coli strains. Anticancer studies have identified compound 6e as highly potent compound with IC50 = 13.08 µg/mL against A375 cell line and 14.21 µg/mL against MDA-MB-231 cell line. In addition, compound 6c also showed very good activity against A375 cell line with IC50 = 13.22 µg/mL. Antibacterial activity results revealed compound 6a and 6e as highly promising agents against all the tested bacterial strains which is equipotent to the standard drug. Molecular docking studies on Aurora A kinase also revealed favourable interactions for target compounds through hydrogen bonds.
Microwave Assisted Synthesis of Some New 2-(4-Substituted phenyl)-3-(1H-indol-4-yl)imidazo[4,5-b]indoles of Biological Interest
Authors: Singh Gurvinder Pal , Sarvanan K. , Sharma Gyanendra Kumar
Published: November 2024

A novel series of imidazo-indole hybrid compounds, focusing on their antibacterial, anticancer and anthelmintic efficacy was designed and synthesized. All the compounds, 2-(4-substituted phenyl)-3-(1H-indol-4-yl)imidazo[4,5-b]indoles (1b-10b) were characterized by FT-IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. Conventional heating and microwave irradiation were both used in the synthesis process, although the microwave irradiation provided better efficiency, faster response times and safer environmental conditions. The synthesized compounds were screened for their antibacterial activity against Gram-positive and Gram-negative pathogens, revealing promising efficacy in several compounds, particularly 2b, 5b and 6b. Furthermore, their anticancer potential was evaluated using the EAC cell line approach, with compounds 1b, 2b, 4b and 5b exhibiting excellent activity, with CTC50 values of 31.25 µg/mL, 51.61 µg/mL, 44.21 µg/mL and 31.25 µg/mL, respectively. Additionally, most compounds also displayed moderate to good anthelmintic activity, highlighting their potential as therapeutic agents.
Design, Synthesis, Anticancer, Antimicrobial and Molecular Docking Studies of Substituted 2-[2,4-Bis-(1-phenyl-1H-[1,2,3]triazol-4-ylmethoxy)phenyl]-1H-benzoimidazole Derivatives
Authors: Barothu Raju , Chilakala Nagendra Babu , Etnoori Sharada , Ayodhya Dasari , Kokku Premalatha
Published: November 2024

In this work, a novel series of substituted 2-[2,4-bis-(1-phenyl-1H-[1,2,3]triazol-4-ylmethoxy)-phenyl]-1H-benzoimidazole derivatives (9a-o) has been designed and synthesized. These new compounds were subjected to analyze the cytotoxicity assays against MCF-7 (breast cancer), HeLa (cervical cancer) and PC-3 (prostrate cancer) cancer cell lines. Among them, compound 9m was most prominent against all cancer cell lines and compounds 9b, 9g, 9j, 9k, 9n and 9o displayed effective inhibition of the cancer cell lines. Meanwhile, the synthesized 1,2,3-triazole derivatives (9a-o) were evaluated for in vitro antibacterial and antifungal activity against Gram-positive bacteria and Gram-negative bacteria as well as fungi, among them compound 9m shows efficient activity. Furthermore, molecular docking investigations were conducted on the newly developed derivative compounds (9a-o), in conjunction with the standard drug doxorubicin, targeting the EGFR kinase protein (PDB ID: 3W33). Compounds 9a and 9m demonstrated exceptional binding energies of -12.1 kcal/mol and -12.2 kcal/mol, respectively, unveiling their superior binding affinity compared to doxorubicin.
Examining the relationship between procurement strategies and organizational performance of Ghanaian firms: How does strategic procurement drive organizational success?
Authors: Adda Godfrey
Published: November 2024

This study investigates the impact of procurement strategies – Strategic Procurement (STRP), Supplier Relationship Management (SRM), Risk Management Practices (RMP), and Sustainable Procurement (SUSP) – on organizational performance among industrial firms in Ghana’s Greater Accra region. A structured questionnaire was administered to 500 participants from industrial companies, resulting in 437 valid responses (an 87.4% response rate). Data were analyzed using partial least squares structural equation modeling (SEM-PLS). We used non-probability and purposive sampling methods to select firms from a list provided by the Association of Ghana Industries. The results show that Strategic Procurement significantly enhances organizational performance. SRM positively influences Strategic Procurement but does not directly impact performance. RMP positively affects both strategic procurement and organizational performance, whereas sustainable procurement positively influences both. The mediation analysis reveals that Strategic Procurement partially mediates the effects of Sustainable Procurement and RMP on organizational performance. However, Strategic Procurement does not mediate the relationship between SRM and organizational performance, suggesting that other mechanisms may drive this relationship. This study highlights the central role of Strategic Procurement in linking sustainable procurement and RMP to improve performance. This emphasizes the need for a holistic approach to procurement strategy, integrating sustainable and risk management practices for optimal outcomes in Ghana’s industrial sector. Organizations should align procurement strategies with strategic goals, foster strong supplier relationships, embed risk management in procurement processes, and integrate sustainability for regulatory compliance and reputational benefits. In addition, organizations should implement performance metrics for continuous improvement.
Sustainable Development Goals (SDGs): SDG 8: Decent Work and Economic Growth; SDG 9: Industry, Innovation and Infrastructure; SDG 12: Responsible Consumption and Production; SDG 17: Partnerships for the Goals
Sustainable personnel management in the hospitality industry: Enhancing organizational performance through employee engagement and commitment
Authors: Vovk Iryna , Vovk Yuriy
Published: November 2024

Purpose: This study investigates the relationships between sustainable personnel management practices, employee engagement, organizational commitment, and organizational performance in the hospitality industry, focusing on hotels and restaurants.
Methodology: A mixed-methods approach was employed, combining quantitative surveys of 500 hospitality employees with qualitative interviews of 20 HR managers and sustainability officers. Structural equation modeling was used to analyze the quantitative data, while thematic analysis was applied to the qualitative data.
Results: The study identifies key drivers of sustainability in personnel management, including employee training and involvement in green initiatives. Implementing sustainable personnel management practices is associated with improved employee engagement, organizational commitment, and organizational performance. The research also highlights challenges and opportunities in implementing sustainable practices in the hospitality industry.
Theoretical contribution: This study extends the existing literature by demonstrating the mediating roles of employee engagement and organizational commitment in the relationship between sustainable personnel management and organizational performance in the hospitality context.
Practical implications: The research provides a step-by-step implementation guide and timeline for hospitality managers to integrate sustainable practices into their personnel management systems. It also highlights the importance of technology in supporting sustainable HR practices and overcoming implementation challenges such as resource constraints and lack of awareness.
Sustainable Development Goals (SDGs): SDG 8: Decent Work and Economic Growth; SDG 11: Sustainable Cities and Communities; SDG 12: Responsible Consumption and Production
The Practice of Islamic Philanthropy in Indonesian History a Book Review of (Filantropi Islam: Sejarah dan Kontestasi Masyarakat Sipil dan Negara di Indonesia)
Authors: Abdillah Faisal Nuja
Published: November 2024

Philanthropic activities have a major contribution to the development of social welfare in Indonesia. The practice of philanthropy has a positive impact on people's lives both in the social and economic spheres. As the majority religious group in Indonesia, Muslims have contributed significantly to improving the welfare of society through Islamic philanthropy movements such as waqf, sadaqah, zakat and infaq. The Islamic philanthropy movement in Indonesia has been massively practiced since the Dutch colonial period until today. The movement has gone through various changes and dynamics in its implementation. The development and dynamics of the practice of Islamic philanthropy in Indonesia could be seen from generation to generation, starting from the Dutch colonial period to the post-reform period. This is a book review of the book Islamic Philanthropy: History and Contestation of Civil Society and the State in Indonesia by Amelia Fauzia. This book review recommends that this book should be widely read by those who seek to deepen knowledge about the practice of Islamic philanthropy in Indonesia from the Dutch colonial period to the reformation era.
Kegiatan filantropi memiliki andil besar dalam pengembangan kesejahteraan masyarakat di Indonesia. Praktik filantropi memberikan dampak positif bagi kehidupan masyarakat baik pada bidang sosial maupun ekonomi. Sebagai kelompok agama mayoritas di Indonesia, umat Islam telah memberikan kontribusi besar dalam upaya meningkatkan kesejahteraan masyarakat melalui gerakan filantropi Islam seperti wakaf, sedekah, zakat, dan infaq. Gerakan filantropi Islam di Indonesia secara masif dilakukan sejak masa penjajahan Belanda hingga sampai saat ini. Gerakan tersebut telah melewati berbagai dinamika dalam pelaksanaannya. Perkembangan dan dinamika praktik filantropi Islam di Indonesia dapat di lihat dari masa ke masa, mulai pada saat masa penjajahan belanda hingga masa pasca reformasi. Artikel ini merupakan book review atas buku Filantropi Islam: Sejarah dan Kontestasi Masyarakat Sipil dan Negara di Indonesia karya Amelia Fauzia. Book review ini merekomendasikan buku ini untuk dibaca oleh kalangan yang ingin memperdalam pengetahuan mengenai praktik filantropi Islam di Indonesia dari masa pemerintahan Belanda, hingga masa era reformasi.
A Model for Developing Political Training Curriculum for Political Parties in Indonesia
Authors: Azhar Khairil , Yuliandri Putrawan , Hartanto H , Indrawan Jerry
Published: November 2024

This paper presents a model for developing a political training curriculum within the context of a political party in Indonesia. It underscores the importance of incorporating institutional values, system enhancement, autonomy in decision-making, and public interaction within the party. As stipulated in Indonesia’s constitution, there are two possible focuses depending on the subjects of such training either the party's administrators and cadres or the general public or community. The paper highlights the need for different teaching strategies and content, depending on the target audience, and emphasizes the necessity for both formative and summative evaluations to ensure the curriculum's ongoing relevance and effectiveness. Ultimately, it provides a blueprint for political parties to create effective, relevant political education programs, tailored to their unique objectives and the needs of their constituents.
Women’s Representation in Banyumas Local Politics in the Perspective of David Easton’s Theory of Systems
Authors: Maula Bani Syarif , Ariyanti Vivi
Published: November 2024

The issue of women in politics becomes important as Indonesia begins to reform political institutions or political processes due of democracy. The purpose of this study is to find out women’s representation in Banyumas Regency, Central Java, in relation to cultural and Islamic values. Islam and Penginyongan cultural values promote traditional gender roles, which may limit women’s participation in politics. However, these values also promote social harmony, community participation, and religious morality, which may encourage women’s participation. Meanwhile, Indonesia’s political system includes a quota system for women’s political representation to increase the number of women in parliament. Data in this research comes from the number of women represented in political positions and their role in representing women’s interests, the meaning of Islamic values and Banyumas’ Penginyongan cultural values. Methods of data collection use interviews, observation, and documents. Using sociological approach, this study concludes that according to David Easton’s theory of systems, the influence of Islam and Penginyongan cultural values on women’s political representation in Banyumas is complex and shaped by a range of factors that interact with each other. Understanding these dynamics is crucial for developing strategies to promote gender equality and women’s political empowerment in the region.
Nutrient efficiency unlocked: Water-soluble fertilizers in horticultural crop production
Authors: Lekhavarshinee J , Sudhalakshmi C , Surendran U , Latha P , Kaleeswari RK , Indurani C
Published: November 2024

Horticultural crops are invaluable to the lands of small and marginal farmers across the nation, making a substantial contribution to the national economy. The significant productivity gap in horticulture is mostly attributable to the inefficient utilization of water and fertilizer resources. Soil fertility has been declining, driven by nutrient depletion and excessive fertilizer application with low nutrient-use efficiency, which hampers productivity despite the steady increase in cultivated area. Numerous research has investigated the application of water-soluble fertilizers to enhance the yield of horticulture crops, achieving greater profitability while minimizing environmental effects.  Water-soluble fertilizers are closely linked to improvements in growth, yield attributes, and soil fertility in various horticultural crops. These fertilizers offer numerous advantages, such as controlling weed growth, reducing the need for herbicides, and enhancing the quality of vegetables and fruits, leading to widespread adoption. Additionally, drip irrigation systems in horticulture have conserved nearly half of the fertilizers and water resources used. Achieving self-sufficiency and sustainability in food production further supports precision farming through water-soluble fertilizers. Consequently, higher nutrient use efficiency (NUE) can be attained, making water-soluble fertilizers an essential component of precision agriculture and site-specific nutrient management.
Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis
Authors: Drieghe Benny , van Loon Gunther , Stuyvaert Sabrina , De Buyzere Marc L. , Bové Thierry , De Backer Tine
Published: November 2024

Because renal artery stenosis (RAS) often presents bilateral, we sought to investigate the renal pressure‐flow relationship and its relation to renin release, in the presence of a contralateral significant stenosis. A porcine model of graded unilateral RAS in the presence of a significant contralateral stenosis was created. The severity of the stenosis was expressed as the ratio between distal renal pressure (Pd) and aortic pressure (Pa). Pd and renal flow velocity were continuously measured using a combined pressure‐flow wire (Combowire®). Hemodynamic measurements and blood sampling for renin, angiotensin, and aldosterone were performed in baseline conditions and during progressive balloon inflation in the renal artery leading to stepwise 5% Pd decrements. Resistive index (RI) was computed as (1‐(End Diastolic V/Maximum Peak Systolic V))*100. A decrease of average peak flow velocity (APV) was observed when distal renal perfusion pressure decreased by 25% and was associated with activation of renin secretion. The RI decreased already for minimal changes in Pd/Pa ratio. In an animal model of unilateral graded RAS in the presence of a significant contralateral stenosis, a 25% decrease in perfusion pressure results in a significant decrease in distal renal flow, causing a more pronounced upregulation of renin secretion when compared to a model of graded unilateral RAS without contralateral significant RAS.
N‐butylphthalide (NBP) ameliorated ischemia/reperfusion‐induced skeletal muscle injury in male mice via activating Sirt1/Nrf2 signaling pathway
Authors: Lu Peng , Li Wei‐Peng , Zhou Ben‐Jun , Tian Wen‐Ze , Lu Xiang , Gao Wei
Published: November 2024

N‐butylphthalide (NBP) has been reported to have potential protective effects in ischemic stroke via its antioxidative properties. The present study was aimed to investigate the protective effects of NBP on ischemia/reperfusion (I/R)‐induced skeletal muscle injury. Mouse model of I/R‐induced skeletal muscle injury and hypoxia/reoxygenation (H/R)‐induced C2C12 myotube injury model were constructed to test the protective effects of NBP both in vivo and in vitro. Our results showed that I/R resulted in skeletal muscle injury, as evidenced by elevated levels of LDH, CK, ROS, 3‐NT, MDA, and 4‐HNE as well as decreased activities of SOD, GSH‐Px, and decreased expression of Myog and MyoD in gastrocnemius muscle, which was ameliorated by NBP treatment. Mechanistically, NBP treatment increased the expression of Sirt1 and Nrf2 in the injured skeletal muscle. Notably, the protective effects of NBP on I/R‐induced skeletal muscle injury was diminished by the treatment of Sirt1 inhibitor. Further studies in H/R‐induced C2C12 myotubes injury model also showed that NBP activated the Sirt1/Nrf2 pathway. NBP treatment upregulated the expression of myog and MyoD in H/R‐stimulated C2C12 myotubes, which was eliminated by silencing of Sirt1. Taken together, our results suggest that NBP may alleviated I/R‐induced skeletal muscle injury by activating Sirt1/Nrf2 signaling pathway.
Viability of Extremely Premature neonates: clinical approaches and outcomes
Authors: Koc Esin , Unal Sezin
Published: November 2024

Viability refers to an infant’s ability to survive outside the womb, which is influenced by both developmental maturity and the quality of medical care received. The concept of periviability, which has evolved alongside medical advancements, describes the stage between viability and nonviability, typically spanning from 200/7 to 25 6/7 weeks of gestation. While the chances of survival are extremely low at the earlier end of this range, the possibility of surviving without significant long-term complications improves towards the later end. The effectiveness of various antenatal and postnatal care practices, particularly those considered to be part of an active approach, plays a crucial role in influencing survival rates and mitigating morbidities. However, the decision to provide such active care is heavily influenced by national guidelines as well as international standards. The variability in guideline recommendations from one country to another, coupled with differences based on gestational age or accompanying risk factors, prevents the establishment of a standardized global approach. This variability results in differing practices depending on the country or institution where the birth occurs. Consequently, healthcare providers must navigate these discrepancies, which often leads to complex ethical dilemmas regarding the balance between potential survival and the associated risks. This review article explores the evolution of the definition of viability, the vulnerabilities faced by periviable infants, and the advancements in medical care that have improved survival rates. Additionally, it examines the viability and periviability definitions, the care and outcomes of periviable infants and recommendations in guidelines.
Advances and challenges in platelet counting: evolving from traditional microscopy to modern flow cytometry
Authors: Chen Yong , Hu Yonggang , Hu Hai
Published: November 2024

Platelet counting is a fundamental clinical test for diagnosing haemorrhagic diseases, coagulation abnormalities, and certain autoimmune disorders, and it also serves as a critical basis for decisions regarding platelet transfusion. Common automated methods for platelet counting include the international harmonization protocol (IHP) based on flow cytometry, CD61 immunoplatelet count (CD61-imm), impedance platelet count (PLT-I), hybrid platelet count (PLT-H), optical platelet count (PLT-O), and fluorescence platelet count (PLT-F). The IHP, based on flow cytometry, is recommended as the reference measurement procedure (RMP) by the Ministry of Health of the People’s Republic of China, the International Council for Standardization in Hematology (ICSH), and the International Society of Laboratory Hematology (ISLH) due to its superior precision and accuracy. Despite the significant improvements in efficiency and standardization brought about by automation, traditional blood smear microscopic examination (PLT-M) remains indispensable in specific scenarios, such as low platelet counts or abnormal platelet morphology, to ensure the accuracy and reliability of platelet counting results from automated methods.
Geographic tokenism on editorial boards: a content analysis of highly ranked communication journals
Authors: Asuman Manfred , Ibrahim Abubakar , Cohen Meghan Sobel , Ekdale Brian
Published: November 2024

Purpose

Research posits that the overrepresentation of certain countries from the Global North contributes to the geographical disparity in knowledge production within communication, media and journalism. Our study sets out to understand geographic tokenism in academia by analyzing the editorial boards of 30 highly ranked journals in communication, media, and journalism studies. We sought to explore if certain institutions and academics from underrepresented regions were overrepresented on journal editorial boards.

Methodology

We content analyzed the members of the editorial boards of 30 highly ranked communication, media and journalism studies journals. From our coded data we were able to identify the individual’s name, role on the editorial board, institutional affiliation, and country of institutional affiliation. Chi square, Pearson’s correlation, and Hierarchical linear modeling were used in analyzing our data.

Findings

Our study found that institutions and academics affiliated to institutions in the Global South are woefully underrepresented on journal editorial boards. On the other hand, we report an overrepresentation of a small number of institutions and scholars from the Global South across the sampled journals in instances where there is representation from the underrepresented regions on journal editorial boards.

Practical implications

Our results show that a journal with more diversity on editorial boards and editorial roles is associated with higher journal ranking.

Social implications

The social implications of our findings rests in the fact that tokenism can impede the diversity of thought that is necessary to move beyond the thorny idea of Western-centered scholarship being considered normative.

Originality

Whereas previous studies have analyzed editorial boards, our study is unique because it includes institutional and individual level analyses of journal editorial board members in our analysis of geographical disparities in knowledge production.
Gas assisted fused deposition modeling: effects of assist gas parameters on print quality and properties
Authors: Zhang Xiaojie , Hong Xiaoyu , Xiao Jianhua , Wang Mengyu , Kim Jinkuk , Cao Lan
Published: November 2024

Fused deposition modeling (FDM) is the most widespread type of additive manufacturing technology. However, the extrusion based process limits the interfacial bonding strength and dimensional accuracy of the printed parts. This paper presents a gas assisted nozzle to localized heating around filament through hot air flow, to maintain the temperature of the filament stays and improve the quality of the bonding. The impact of assist gas temperature (55 °C–295 °C), flow rate (1 L/min–3 L/min) and pressure (0.2 MPa–0.5 MPa) on filament extrudation, layer consolidation, and the printed parts thermal properties, as well as the mechanical properties were investigated. It is shown that the swell ratio of extruded filament and dimensional difference of layer thickness can be controlled by varying the assist gas parameters. The assist gas raises the temperature of the exudate and the existing layer near the nozzle, leading to 73.6 % increase in crystallinity, 19.4 % increase in tensile strength and 48.4 % impact strength. The gas assisted pre-heating approach represents an effective way to increase interlayer strength can be employed as an additional control parameter to improve the thermal and mechanical properties of the FDM printed parts.
Effect of vitamin D and omega-3 on the expression of endoplasmic reticulum-associated protein degradation and autophagic proteins in rat brain
Authors: Alimogullari Ebru , Kartal Bahar , Bozkurt Mehmet Fatih , Demir Hazal , Sacik Uygar , Bhaya Muhammed Nasir
Published: November 2024

Objectives

Valosin-containing protein (p97/VCP) and its cofactor, small p97/VCP-interacting protein (SVIP), are involved in the endoplasmic reticulum-associated degradation pathway (ERAD). We investigated the cellular localization of vitamin D receptor (VDR), ERAD, and autophagic proteins (LC3B and p62) in rat brain tissue.

Methods

There were four groups consisting of 24 Wistar albino rats: control and treatment groups for vitamin D, omega-3, and both vitamin D and omega-3. Brain tissues were stained with hematoxylin-eosin, azan trichrome, and toluidine blue for histopathological evaluation. The immunohistochemistry assay was performed for VDR, p97/VCP, SVIP, LC3B, and p62 in rat brain sections.

Results

The immunoexpression of VDR and p97/VCP was significantly increased in hippocampus and cortex of brain tissue from the vitamin D-supplemented group. Furthermore, the protein expression level of SVIP reached the highest level in vitamin D-treated group. LC3B and p62 revealed reduced expressions in vitamin D-treated group in rat brain and hippocampus, in contrast to p97/VCP, SVIP, and VDR.

Conclusions

Vitamin D and omega-3 supplementations had no negative effects at a cellular level on hippocampus and cortex of the brain tissue. Vitamin D increased the expression of the proteins that are related to the ERAD pathway, whereas it reduced the expression of the proteins in the autophagy pathway. Also, in this study, SVIP expressions were shown in rat hippocampus and cortex of the brain tissue.
Assessing medical biochemistry professionals’ knowledge, attitudes, and behaviors regarding green and sustainable medical laboratory practices in Türkiye
Authors: Yurt Emine Feyza , Alpdemir Medine , Şeneş Mehmet
Published: November 2024

Objectives

This study aims to evaluate the knowledge, attitudes, and behaviors of medical biochemistry professionals in Türkiye regarding green and sustainable medical laboratory (GSML) practices. It also seeks to identify the most common and challenging barriers to adopting GSML practices.

Methods

A cross-sectional survey was conducted among 130 medical biochemistry professionals, including academicians, specialists, and residents, across various hospital types in Türkiye. The survey, distributed via Google Forms, consisted of 29 questions divided into five sections covering participant characteristics, knowledge about GSML, individual attitudes, laboratory practices, and awareness of EFLM guidelines. Data were analyzed using Excel and SPSS.

Results

The survey revealed that only 10.8 % of participants received education on sustainability during their specialty training. Despite this, 76.2 % had heard of the concept of sustainability, although 74.6 % were unaware of green chemistry principles. Individual environmental practices were generally positive, with 96 % of participants turning off lights and equipment when not in use. However, significant gaps were found in laboratory GSML practices, particularly in energy (only 44 % of laboratories regularly defrost refrigerators and freezers) and water management (only 40.8 % perform regular maintenance). The most common barriers to GSML implementation were identified as education and awareness (46.2 %), sustainability (24.6 %), cost (15.4 %), motivation (8.5 %), and communication (2.3 %).

Conclusions

There is a critical need for enhanced education and awareness of GSML practices. While individual environmental behaviors are positive, systemic changes in laboratory practices are necessary. Addressing the identified barriers, particularly through targeted educational initiatives, is essential for promoting sustainable practices in medical laboratories.
Unravelling Possible Worlds in Atwood’s The Handmaid’s Tale: Examining Rhetorical Devices
Authors: Hatamzadeh Esfahani Somayeh , Rostami Masoud
Published: November 2024

Recently, considerable literature has grown up around the theme of possible worlds as a new way of understanding literary texts. The main thrust of Possible Worlds Theory lies within the world-creating power of the reader’s imagination. Despite a considerable amount of literature on Possible Worlds Theory, investigating the consistent correlation between this theory and rhetorical devices such as intertextuality and metaphor still seems a productive endeavour. What remains unclear is how intertextual references and metaphors trigger alternative possible worlds, which may or may not be consistent with an actual world. In this regard, employing Ryan’s Possible Worlds Theory (1991), this paper seeks to unravel the underlying possible worlds of Margaret Atwood’s The Handmaid’s Tale (1985) by tracing its rhetorical devices, which develop the main idea of the novel. Additionally, a significant feature of postmodernist writing, i.e. ‘fiction within fiction,’ is examined to assess characterization. This research provides an exciting opportunity to advance our knowledge of possible worlds within the poetics of postmodernist fiction.
‘Nostalgia is the English Disease’ – Or is it? Jonathan Coe’s Middle England (2018)
Authors: Mengel Ewald
Published: November 2024

In common understanding, nostalgia is a past-oriented attitude that makes people turn their backs on the present and glorify former times. It leads to a self-indulgent ‘ossification’ of one’s thoughts and results in escapism and the break with contemporary reality. Jonathan Coe’s Middle England, one of the first English Brexit novels, is deeply steeped in the past and in certain forms of nostalgia that greatly contribute to the novel’s overall atmosphere. One of these forms, the hankering after England’s glorious past and the lost Empire, may easily be related to Brexit. This type of nostalgia, however, which contributed to England’s leaving of the European Union, is only one form of nostalgia which Coe makes use of. What I want to show is that there is another type of nostalgia in the novel that is future-oriented and filled with positive social and psychological energies. It is this type of nostalgia that characterizes most of Coe’s protagonists and that is responsible for the structure of his novel.
Of Whales and Mushrooms: Anna Tsing’s and John Ironmonger’s Polyphonic Storytelling
Authors: Marik Eva
Published: November 2024

Growing discontent with the ideological formations of Hobbesian self-interest and capitalist progress narratives are countered in Anna Tsing’s The Mushroom at the End of the World (2015) and John Ironmonger’s The Whale at the End of the World ([2015] 2021) through the use of Bakhtinian polyphony which textually manifests collaborative survival. The converging narrative strategies of these books reshape the fiction/non-fiction boundary from opposite ends of the literature/science writing spectrum.
About «post-politics» in the era of «post-science». New trends in electoral processes in the countries of South-Eastern Europe
Authors:   Institute of Europe of Russian Academy Sciences, Kandel Pavel , Lunkin Roman ,   Institute of Europe of Russian Academy Sciences, Drozhzhina Elena ,   Institute of Europe of Russian Academy Sciences
Published: November 2024

The monograph examines fundamentally new phenomena and patterns in electoral processes in the countries of South-Eastern Europe at the turning point of two eras. A series of essays on presidential, parliamentary and local elections and the specifics of power formation in the states of the region ends with a section aimed at comprehension of the new phenomena. The very nature of their emergence, according to the author, indicates the dysfunction of the existing political system and its transition to a different qualitative state. The work can be helpful both for experts on the region and for anyone who studies the modern political systems and electoral practices.
Mixed convection nonaxisymmetric Homann stagnation-point flow under the influence of magnetic field
Authors: Mardi Chhatu Manuel , Mahapatra Tapas Ray
Published: November 2024

In the present study, we have investigated the steady mixed convection nonaxisymmetric Homann stagnation-point flow in the presence of a magnetic field over a vertical flat wall immersed in a viscous and incompressible fluid. The magnetic field is applied in the normal direction to the plate. The governing equations are reduced to a system of nonlinear ordinary differential equations with suitable boundary conditions by applying similarity transformations to the equations and the boundary conditions. Using an efficient shooting method, the transformed equations are numerically solved. The solution involves the dimensionless governing parameters: γ representing the shear-to-strain-rate ratio, a mixed convection parameter λ, a magnetic field parameter M, and Prandtl number Pr. An important observation is that dual solutions exist for a certain range of mixed convection parameter λ. It is noticed that critical values λc of λ are found in opposing flow, which produce two solution branches by making saddle-node bifurcation at λ = λc. Numerical results are obtained for representative values of γ, λ, and M and are explored in depth. Through the use of graphs, the properties of the flow and temperature profiles for various values of the governing parameters γ, λ, and M are examined. Also, we examined how the solution varied with λ for representative values of M (magnetic field parameter). A parametric analysis is conducted to investigate how different governing parameters affect the characteristics of fluid flow and temperature. Also, we derive asymptotic results for large λ.
Results on integral inequalities for a generalized fractional integral operator unifying two existing fractional integral operators
Authors: Paul Supriya Kumar , Mishra Lakshmi Narayan , Mishra Vishnu Narayan
Published: November 2024

The main aim of this article is to design a novel framework to study a generalized fractional integral operator that unifies two existing fractional integral operators. To ensure the suitable selection of the operator and with the discussion of special cases, it is shown that our considered fractional integral generalizes the well-known Atangana–Baleanu fractional integral (AB-fractional integral) and the ABK-fractional integral. Conditions are stated for the generalized AB-fractional integral operator (GAB-fractional integral operator) to be bounded in the space Xcp (γ1,γ2). We also provide a fractional product-integration formula for this operator. Furthermore, we generalize the reverse Minkowski’s inequality and the reverse Hölder-type inequality by utilizing the GAB-fractional integral operator. Additionally, some other types of integral inequalities are established, and several special cases are noted. The concepts in this article may influence further research in fractional calculus.
Impact of multiple time delays on bifurcation of a class of fractional nearest-neighbor coupled neural networks
Authors: Li Weinan , Liao Maoxin , Huang Haoming , Xu Changjin , Li Bingbing
Published: November 2024

In this paper, the impacts of multiple time delays on bifurcation of a class of fractional nearest-neighbor coupled neural networks are considered. Firstly, the sum of time delays is selected as a parameter, and the fractional nearest-neighbor coupled neural network model is linearized to obtain the corresponding characteristic equation. Then, utilizing stability and bifurcation theory of fractional-order delay differential equations, we investigate the effect of time delays on the system’s stability and bifurcations. The results show that when the time lag exceeds the critical value, the system will lose stability and generate Hopf bifurcation. Finally, the correctness of the conclusions in this paper is verified through numerical simulation.
Rehabilitating Psychological Well-being in the Postpartum Phase: The Impact of Yoga Therapy and Overcoming Challenges
Authors:   Pondicherry University, W Vinu , Kabeer Dilshith A. ,   Pondicherry University
Published: November 2024

Purpose. The study aimed to promote, foster, and cultivate psychological well-being among women during their postpartum phase and devise yoga-based interventions that enhance the psychological well-being of postpartum women.

Material and Method. A 'mood and self-esteem measure' was employed to evaluate 50 participants who had recently given birth at Annamalai University Hospitals in Chidambaram, Tamil Nadu, India. In the yoga sessions, these individuals were randomly assigned to either a yoga group (N = 25) or a control group (N = 25) comprising 16 instructional units conducted over eight weeks. Those who completed the postpartum therapy and participated in the study received continuous supervision. The yoga sessions took place in a public setting, and the duration gradually increased from 25 minutes, including setup and conclusion, in the initial four weeks to 35 minutes from the fifth week to the eighth week.

Result. The group participating in yoga demonstrated significantly more pronounced improvements in depression, anger, and tension compared to the control group, indicating moderate to substantial benefits. Yoga therapy groups and control of anger (t=44.10 and.338) and the depression (t =74.789 and 1.653). Tension (t =24.608 and .428). The yoga therapy groups exhibited significant alterations.

Conclusion. The results endorse yoga as a potential complementary therapy for women in the postpartum phase.
Effect of Postural Stability Exercises on Gait Parameters in Children with Spastic Diplegia Cerebral Palsy: An Experimental Trial
Authors:   College of Medical Sciences (Allied Health Sciences) IIMT University, Gulyani Latika , Vadivelan Kanniapan ,   SRM College of Physiotherapy, SRM Institute of Science and Technology, Singh Anshika ,   School of Allied Health Science, Galgotias University, Agarwal Shagun ,   School of Allied Health Science, Galgotias University, Raghav Sumit ,   School of Allied Health Science, Galgotias University
Published: November 2024

Postural stability helps maintain the position of the body within the support area to maintain control, but this postural stability is affected in children with cerebral palsy during static or dynamic activities. However, the practical application of postural stability exercises combined with muscle strengthening has not been studied in spastic diplegia cerebral palsy children with gait difficulties.

Purpose: To study the effect of postural stability exercises on the gait and posture of children with spastic diplegia cerebral palsy.

Materials & Methods. 23 subjects with spastic diplegia cerebral palsy within the age group of 8 to 15 years, both male and female were randomly allocated into two groups Group A (Experimental) n=12 and Group B (Control) n=11, voluntarily participated and EVGS and DGI were used to assess the posture, gait, and functional capacity as outcome measures. Pre-test and post-test values were used for the interpretation of data.

Results: The mean difference of 3.25 with a t-value of 8.74 at a significance of 0.000 (p<0.005) was calculated which shows a statistically significant difference between the pre and post-values of Group A and the mean difference of 1.63 with a t-value of 8.05 at a significance of 0.000 was calculated, which is statistically significant.

Conclusion: Combined effect of postural stability exercises along with muscle strengthening exercises have a significant effect on the gait functions in children with spastic diplegia CP of GMFCS level II and III.
Should we cure or care people living with type 1 diabetes? a survey
Authors: Strollo Felice , Guarino Giuseppina , Satta Ersilia , Chiarello Maria , Caccavale Giuseppe , Gentile Sandro
Published: November 2024

At the moment of type 1 diabetes mellitus (T1DM) diagnosis communication, adult patients experience disorientation, fear and uncertainty in front of permanent, adverse changes in their habits before considering insulin as a powerful tool to control disease, improve quality of life, and prevent severe complications. Indeed, an adequate series of services is required to grant not only medical but also humanistic assistance aimed to interpret persons’ needs and whish. This survey had 146 people with T1DM consecutively referring to the outpatient wards of a Diabetes Consortium in Italy complete a a self-administered questionnaire to examine some crucial moments experienced by at the time of diagnosis, during the educational process, and when feeling the voice tone of the professionals revolving around the treatment process while sending out their messages. A merciless picture emerged from the questionnaires, being most participants unsatisfied with the healthcare team approach, which they judged too technical and less prone to effective education. A missing point was especially helpful training on practical aspects of diabetes treatment, especially regarding appropriate insulin injections technique and the severe long term disease consequences complications deriving from poor compliance to them. Much remains to be done to improve the daily clinical, social, and personal conditions of persons with T1DM as pursuing the goal of euglycemia when treating diabetes involves a whole, complex process, including a series of actions aimed at supporting PwD in improving their interpersonal relationships, understanding their individual needs, and breaking down the barriers raised by old-fashioned, outdated professional attitudes.
The importance of assisted body building training in Lumbociatalgia
Authors: De-Oliveira Bianca Gabriella , Aires Marques Melissa Alves , de Queiroz Letícia Magalhães , Borges Peres Lucas Dias , Picchi Martins Jessica Santos , Ribeiros Matheus Dias , Ribeiros Matheus Dias , Rezende Renan Rodrigues , Bataglia Gustavo da Silva , Padula Silva Fernando Cesar
Published: November 2024

Low back pain is one of the most common causes of morbidity, and functional and economic incapacity. It is currently the fifth leading cause of medical consultation, and according to epidemiological studies, between 65 and 90% of adults may suffer from lumbosciatalgia. Physical activity improves quality of life and reduces the symptoms of chronic pain. Assisted weight training consists of performing the sport under the guidance and supervision of a trained professional. This study aims to discuss the importance of assisted weight training in lumbosciatalgia. This is a literature review study, using the following databases: PubMed, Lilacs, and ScienceDirect, selecting 15 articles that best met the study criteria, published from 2014 to 2021. It is estimated that around 60% of the Brazilian population does not practice any physical activity. The best way to prevent future low back pain is to avoid resting, exercise within the proper limits, and be assisted by a professional. It can be concluded that exercise is important for lumbosciatalgia and low back pain, as it reduces inflammatory markers, causes analgesia, and is an excellent therapy for preventing future low back pain and improving the individual's quality of life.
DESIGN OF THE OPTIMUM GEOMETRY OF THE INDUCTOR WINDING FOR HEATING THE INNER RINGS OF AXLE BEARINGS IN WHEEL PAIRS OF CARRIERS IN THE METRO
Authors:   Institute of Electrodynamics of the National Academy of Sciences of Ukraine,  Beresteiskyi ave., 56, Kyiv, 03057, Ukraine, Zharkin A.F. , Pazieiev A.H. ,   Institute of Electrodynamics of the National Academy of Sciences of Ukraine,  Beresteiskyi ave., 56, Kyiv, 03057, Ukraine, Bondar O.I. ,   Institute of Electrodynamics of the National Academy of Sciences of Ukraine,  Beresteiskyi ave., 56, Kyiv, 03057, Ukraine
Published: November 2024

The process of high-frequency induction heating of the inner rings of bushing bearings before disassembly, which is carried out during the repair work of wheel pairs of subway cars, has been investigated. Physical modeling of the heating process was carried out at a frequency of 10 kHz and using an inductor with a three-row winding of 17 turns, the length of which was equal to the length of the ring. It is shown that when varying the heating time and the power transmitted to the part, it is not possible to ensure the selection of an acceptable heating mode for normal disassembly from the point of view of ensuring repeatability of results and preventing local overheating of the part. Calculations were carried out in the COMSOL environment on the finite element model of the process of heating the ring of a bushing bearing with a constant number of turns for different variants of the geometry of the inductor winding, that is, the number of winding rows, the number of turns in a row and their location relative to the inner rings of the bearings. It is shown that the geometric shape of the inductor winding has a significant effect on the distribution of specific heat emissions along the surface of the parts. The optimized geometry of the winding was determined, which ensures the necessary heating dynamics and the absence of local overheating zones of the bearing rings, which allows to reduce the proportion of rejected parts. Ref. 5, fig. 6, table.