bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Material Supplier Selection in Laminated Bamboo Shipyards Using the Analytical Hierarchy Process Method
Authors: Safarudin Abdul Rachman , Supomo Heri , Supomo Wikaranosa Scotiandharu
Published: May 2023

The material supply chain is an essential part of the shipbuilding industry. For this reason, it is necessary to select suppliers who can support the material needs of ship production. Qualitative and quantitative factors are multi-criteria problems in supplier selection. The Analytical Hierarchy Process (AHP) method effectively determines an integrative approach to supplier selection. This research is applied to a laminated bamboo shipyard to evaluate several companies that can be used as material suppliers. The analysis was carried out using expert choice software by calculating the weight of each criterion and sub-criteria. The analysis results obtained the priority of the primary material supplier with the Kediri area (S1) as the supplier of bamboo material for ship construction with a global weighting value of 0.363. PT. An (S5) located in the Surabaya area is the next top priority as a supplier of adhesive and finishing 1st material components with global weighting values of 0.434 and 0.427, respectively. PT. E (S9) is located in the Semarang area as a priority supplier of finishing 2nd material components with a global weighting value of 0.490. UD. G (S11) is located in the Surabaya area as a priority supplier of ship mold components with a global weighting value of 0.456. In addition, UD. J (S14), located in the Surabaya area, is a priority supplier of material components for clamps, sanding, and cutting blades with a global weighting value of 0.496 and 0.351.
Children of the Enemy or the Future of Socialism? Being a Child of an American Soldier in Socialist Czechoslovakia
Authors: Korhel Michal
Published: May 2023

After the US Army liberated Czechoslovakia and consequently left the country at the end of 1945, local women started to give birth to children fathered by American soldiers. As a result of their multifaceted origin these children had to face various challenges in post-war Czechoslovakia. Not only did the perception of their fathers change from liberators to enemies of socialism. Being illegitimate, children of US soldiers also challenged traditional social values. In the case of mixed-race children, their different physical characteristics (e. g. skin color) could make them targets to manifestations of racism in Czechoslovak society. Based on an analysis of available archival sources, this study asks whether there was a specific state policy towards children of American soldiers. Furthermore, with the help of oral history interviews the study also examines the impact the various aspects of these children’s origin had on their everyday life.
Politika identit v čínských enklávách amerických měst: muzejní narace
Authors: Topinka Daniel , Havlíček Jakub
Published: May 2023

This text deals with ethnopolitical identities as presented to visitors to Chinese enclaves by their inhabitants themselves in museums of Chinese enclaves in the United States. We focus on three locations: San Francisco, New York, and Chicago. The text briefly introduces the history of Chinese immigration and the establishment of the Chinese as a minority within the American nation. It focuses on the content of the permanent exhibitions, it describes and analyzes the forms of representing Chinese identities in these museums. At a theoretical level, we draw on the concept of identity politics. We apply a syntagmatic approach, using a method of narrative analysis of the exhibitions, comparing the sequential development of the museum narrative in the order it is intended to be presented to museum visitors. We identify the various elements of the design of the exhibitions and the themes presented. Our research was conducted during field trips of the authors between 2013–2019. The exhibitions come with a so-called canonical narrative that is linearly conceived and introduces the “harmony” of Chinese and American identities. The canonical narrative is coherently and logically conceived, the presented themes support the whole narrative. The canonical narrative illuminates the presence of Chinese immigrants as a journey from exclusion to full emancipation and recognition of their equality, with reference to cultural specifics of Chinese sociocultural identities.
Optimal assist strategy exploration for a direct assist device under stress‒strain dynamics
Authors: Zijian Li , Fangqun Wang , Fenglian Zhu , Yu Gao , Shaojun Wang
Published: May 2023

Objectives

The aim of this paper is to introduce a new assist strategy for a direct assist device that can enhance the heart’s pumping efficiency and decrease the chances of myocardial injury in contrast to the conventional assist strategy.

Methods

We established a finite element model of a biventricular heart, divided the ventricles into several regions, and applied pressure to each region separately in order to identify the primary and secondary assist areas. Then combined and tested these areas to obtain the optimal assist strategy.

Results

The results indicate that our method exhibits an assist efficiency approximately ten times higher than that of the traditional assist method. Additionally, the stress distribution in the ventricles is more uniform after assistance.

Conclusions

In summary, this approach can result in a more homogenous stress distribution within the heart while also minimizing the contact area with it, which can reduce the incidence of allergic reactions and the likelihood of myocardial injury.
A Flexible Surface Description for Arbitrarily Shaped Dielectric Lens Antennas
Authors: Jaschke Thomas , Rohrdantz Benjamin , Jacob Arne F.
Published: May 2023

A method to efficiently describe arbitrarily shaped dielectric lens antennas based on spherical harmonics is proposed. It makes use of a Fourier-Laplace series and requires a low number of expansion coefficients, only. Symmetries can be included to impose special geometries or to further reduce the number of coefficients. The efficiency of the approach enables a fast optimization of the surface. This is particularly useful for electrically small lenses. Three exemplary lens designs based on different specifications are obtained through optimization. The manufacturing is discussed and the radiation characteristics are explored and validated through measurements.
Membrane-anchored substrate binding proteins are deployed in secondary TAXI transporters
Authors: Roden Anja , Engelin Melanie K. , Pos Klaas M. , Geertsma Eric R.
Published: May 2023

Substrate-binding proteins (SBPs) are part of solute transport systems and serve to increase substrate affinity and uptake rates. In contrast to primary transport systems, the mechanism of SBP-dependent secondary transport is not well understood. Functional studies have thus far focused on Na+-coupled Tripartite ATP-independent periplasmic (TRAP) transporters for sialic acid. Herein, we report the in vitro functional characterization of TAXIPm-PQM from the human pathogen Proteus mirabilis. TAXIPm-PQM belongs to a TRAP-subfamily using a different type of SBP, designated TRAP-associated extracytoplasmic immunogenic (TAXI) protein. TAXIPm-PQM catalyzes proton-dependent α-ketoglutarate symport and its SBP is an essential component of the transport mechanism. Importantly, TAXIPm-PQM represents the first functionally characterized SBP-dependent secondary transporter that does not rely on a soluble SBP, but uses a membrane-anchored SBP instead.
The many faces of ribosome translocation along the mRNA: reading frame maintenance, ribosome frameshifting and translational bypassing
Authors: Poulis Panagiotis , Peske Frank , Rodnina Marina V.
Published: May 2023

In each round of translation elongation, the ribosome translocates along the mRNA by precisely one codon. Translocation is promoted by elongation factor G (EF-G) in bacteria (eEF2 in eukaryotes) and entails a number of precisely-timed large-scale structural rearrangements. As a rule, the movements of the ribosome, tRNAs, mRNA and EF-G are orchestrated to maintain the exact codon-wise step size. However, signals in the mRNA, as well as environmental cues, can change the timing and dynamics of the key rearrangements leading to recoding of the mRNA into production of trans-frame peptides from the same mRNA. In this review, we discuss recent advances on the mechanics of translocation and reading frame maintenance. Furthermore, we describe the mechanisms and biological relevance of non-canonical translocation pathways, such as hungry and programmed frameshifting and translational bypassing, and their link to disease and infection.
The Sibylline Books in the Early Roman Empire
Authors: Satterfield Susan
Published: May 2023

Many scholars have suggested that Augustus and Tiberius were afraid of prodigies and the Sibylline Books. Not only, they claim, did these emperors suppress prodigy reports, they also destroyed parts of the official Sibylline collection. This paper argues that the early emperors were not afraid of state divination. Rather than being a threat to their power, prodigies, expiations, and the Sibylline Books were used to confirm their position and to counter the authority of competing forms of divination.
Why we need a gradient approach to word order
Authors: Levshina Natalia , Namboodiripad Savithry , Allassonnière-Tang Marc , Kramer Mathew , Talamo Luigi , Verkerk Annemarie , Wilmoth Sasha , Rodriguez Gabriela Garrido , Gupton Timothy Michael , Kidd Evan , Liu Zoey , Naccarato Chiara , Nordlinger Rachel , Panova Anastasia , Stoynova Natalia
Published: May 2023

This article argues for a gradient approach to word order, which treats word order preferences, both within and across languages, as a continuous variable. Word order variability should be regarded as a basic assumption, rather than as something exceptional. Although this approach follows naturally from the emergentist usage-based view of language, we argue that it can be beneficial for all frameworks and linguistic domains, including language acquisition, processing, typology, language contact, language evolution and change, and formal approaches. Gradient approaches have been very fruitful in some domains, such as language processing, but their potential is not fully realized yet. This may be due to practical reasons. We discuss the most pressing methodological challenges in corpus-based and experimental research of word order and propose some practical solutions.
Beyond “Psychic Income”: An Exploration of Interventions to Address Work-Life Imbalances, Burnout, and Precarity in Contemporary Nonprofit Work
Authors: Robichau Robbie Waters , Sandberg Billie , Russo Andrew
Published: May 2023

Nonprofit scholars and practitioners alike adhere to a long-held assumption that nonprofit work is, and will remain, inherently meaningful work. The long-term marketization of the nonprofit sector coupled with the influence of the COVID-19 pandemic has undercut this narrative. Our research on meaningful nonprofit work indicates that while many nonprofit workers do find their work meaningful, pay, flexibility, and work/life balance are increasingly important to them. This commentary suggests that nonprofit leaders can no longer presume that workers motivated by prosocial values will seek out and stay with nonprofit work, satisfied with the “psychic income” that comes from doing good work. Nonprofits must be managed and led differently such that they center workers’ contemporary needs and desires. Organizational and public policy initiatives around pay equity and flexible work can support such a transition for the nonprofit sector.
Early diagnosis and prognosis of hepatocellular carcinoma based on a ceRNA array
Authors: Wang Li-xin , Kong Ao-ran , Dong Hui
Published: May 2023

Objectives

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths, due to high morbidity, a low early diagnosis rate, and poor prognosis. It is essential to explore competitive endogenous RNA (ceRNA) arrays for early diagnosis and prognosis of HCC.

Methods

The original gene expression profiles of differentially expressed lncRNA, miRNA and mRNA in HCC were downloaded from TCGA database. Differentially expressed lncRNA-miRNA and miRNA-mRNA interaction pairs were extracted from miRcode and starBase, a ceRNA network was constructed, and GO annotation and KEGG pathway analyses were performed. Cox regression and Kaplan-Meier survival analysis screening identified core genes in the network associated with HCC survival, centering on miRNA, which were screened using ceRNA arrays. qRT-PCR was used to detect the expression level of key genes in clinical samples. Dual luciferase reporter gene assays were used to verify the target binding relationship among lncRNA, mRNA, and miRNA. ROC curves were used to analyze the diagnostic efficacy of the ceRNA array.

Results

A total of 8 lncRNAs, 5 miRNAs, and 21 mRNAs were used to construct a ceRNA network. Functional enrichment analysis showed that mRNAs in the ceRNA network were mainly enriched in 14 signaling pathways, especially microRNAs in cancer. Survival analysis showed that lncRNA FOXD2-AS1 and miRNA miR-9-5p were related to the prognosis of HCC, and the targeted binding relationships between mRNAs. STMN1, COL15A1, and CCNE2 and miR-9-5p from the TargetScan, starBase, miRDB, and PicTar databases were reliable. qRT-PCR showed that expression levels of FOXD2-AS1, miR-9-5p, STMN1, COL15A1, and CCNE2 were upregulated in HCC tissues. Dual luciferase reporter assays showed that FOXD2-AS1 and STMN1 had a targeted binding relationship with miR-9-5p, but not with COL15A1 or CCNE2. The area under the curve of the candidate ceRNA array (FOXD2-AS1/miR-9-5p/STMN1/COL15A1/CCNE2) was higher than that of each member and ceRNA combination (FOXD2-AS1/miR-9-5p/STMN1).

Conclusions

The candidate ceRNA array formed by FOXD2-AS1/miR-9-5p/STMN1/COL15A1/CCNE2 could be a biomarker for early diagnosis and prognosis of HCC.
Screening and biomarker assessment of ferroptosis genes FLT3 and ALOX5 in lung adenocarcinoma
Authors: Zheng Yuansi , Su Ying , Ruan Lei , He Qingfeng , Gong Linna , Li Jieyi
Published: May 2023

Objectives

Ferroptosis is a unique process of cell death that specifically requires iron. We investigated ferroptosis genes and their function in lung adenocarcinoma (LUAD) patients.

Methods

Data on the expression levels of genes associated with ferroptosis were collected from the FerrDb and the Cancer Genome Atlas database. Kaplan-Meier Plotter was employed to generate the survival curves of LUAD patients with high vs low expression of ferroptosis genes. The relationship between immune cell infiltration and ferroptosis genes was analyzed via TIMMER. Immunohistochemical staining was employed to quantitatively evaluate gene expression in 43 LUAD patients.

Results

A total of 89 ferroptosis genes were found to have significant differential expression between LUAD and normal tissues (p<0.05), 23 of which were selected and consistent prognostic trends were observed based on analysis of RNA-Seq and RNA microarray data (p<0.05). These 23 ferroptosis genes were assigned to 10 high-abundance pathways and 18 functional categories. Besides, the expression of ALOX5 and FTL3 demonstrated a positive correlation with sets of immune markers. The expression of ALOX5 exhibited a positive correlation with the levels of infiltration of dendritic cells, macrophages, neutrophils, and CD4+ T cells, while FLT3 expression correlated with the infiltration of B cells, CD4+ T cells, neutrophils, and dendritic cells. Furthermore, ALOX5 was confirmed to be downregulated in lung tumor tissues (p<0.01).

Conclusions

Our findings show that the ferroptosis genes FLT3 and ALOX5 play prominent roles in immune cell infiltration during LUAD progression and may serve as prognostic biomarkers for LUAD.
Socioeconomic, Technological, and Cultural Adaptation of the Mesolithic Population in Central-Eastern Cantabria (Spain) in the Early and Middle Holocene
Authors: Mercedes Pérez-Bartolomé
Published: May 2023

This article presents the research on the palaeoenvironmental changes that took place at the end of the Tardiglacial, in the early and middle Holocene, observed in sites of anthropic origin in central-eastern Cantabria. Through the comparative analysis of the economy, the settlement pattern, and the industries of the Azilian and Mesolithic settlements, we try to infer the repercussions they could have had on the last hunter-gatherers, in order to adapt to the modification of the territory, the change in the available resources, and the socio-economic consequences they could have had on the settlement. The radiocarbon record of central-eastern Cantabria and the Cantabrian region (Northern Spain) between 9.5 and 7.9 ka cal BP is analysed in order to assess the impact of the cold events that occurred in 9.3 and 8.2 ka cal BP, identified in the palaeoenvironment.
Multinuclear solid state nuclear magnetic resonance for studying CsPbBr3 nanocubes
Authors: Scarperi Andrea , Landi Noemi , Gabbani Alessio , Jarmouni Nabila , Borsacchi Silvia , Calucci Lucia , Pucci Andrea , Carignani Elisa , Pineider Francesco , Geppi Marco
Published: May 2023

Cesium lead bromide perovskite (CsPbBr3) nanocrystals have raised impressive interest as efficient and stable optoelectronic materials. Size and morphology play important roles in the final performances of these materials and advanced characterization studies are needed to elucidate structural and surface properties. In this work, CsPbBr3 cubic nanocrystals were obtained by colloidal synthesis and characterized by multinuclear Solid State NMR (SSNMR), complemented by X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM) and optical spectroscopy. The multinuclear NMR approach allowed the different components of the nanocubes to be separately observed. In particular, the surface ligands and their interactions with the nanocubes surface were investigated by 1H and 13C NMR experiments, while the structural investigation of the perovskite nanocubes was addressed by exploiting 207Pb and 133Cs spectral properties in comparison with bulk CsPbBr3. Static 207Pb NMR spectra indicated a possible contribution of chemical shift anisotropy from the 207Pb nuclei of the outer layer. The 133Cs NMR spectra showed signals with different chemical shifts for cesium atoms in at least three regions of the nanocubes, from the inner core to the surface, which were interpreted in terms of cubic layers with different distances from the surface using a simple geometrical model. This interpretation was also supported by 133Cs longitudinal relaxation time measurements.
A Peircean framework for analyzing subjectivity in film: a nine-field ocularization matrix
Authors: Bekaert Marc , Coëgnarts Maarten
Published: May 2023

The goal of this article is to offer a new model for the study of ocularization in film grounded in the semiotic pragmatism of Charles Sanders Peirce. We first present a literature overview addressing the state of research regarding the theorization of ocularization in film studies. Second, we discuss Peirce’s three universal categories (Firstness, Secondness, and Thirdness) on which our model will be based. Third, we argue how the theme of ocularization in film, as outlined in the first part, can be theorized anew through these categories. This will result in the introduction of a nine-field matrix that will allow us to systemize all kinds of instances of subjectivity in cinema. Lastly, we will demonstrate the empirical usefulness of this model by illustrating each of the matrix’ nine categories through a discussion of Steven Soderbergh’s film Kimi (2022).
Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study
Authors: Sözen Mustafa Mert , Kartalcı Şükrü
Published: May 2023

Objectives

Schizophrenia (SZ) is a severe multifactorial disease. NRG1 is a gene acting in the development of SZ. A number of NRG1 single nucleotide polymorphisms (SNPs) and their haplotypes are associated with SZ. In the present study, we investigated the association of a NRG1 haplotype (G-C in rs6988339-rs3757930 frame) which was reported to be associated with SZ, and two other SNPs in the same gene (rs74942016, rs80127039) whose rare missense alleles were found in SZ patients. Also, we analyzed disease associations of potential new haplotypes constructed by the variants of these SNPs.

Methods

We genotyped 4 SNPs in a sample consisting of 302 SZ patients and 333 controls from a local Turkish population. We tested the disease associations of these variants at single SNP, haplotype and diplotype levels in case-control design.

Results

At single SNP level, the CC genotype of rs3757930 was associated with SZ (p=0.038). The previously reported association of G-C haplotype in rs6988339-rs3757930 frame was absent (p=0.416), but we found another haplotype (C-G in rs3757930-rs74942016, p=0.018) and three diplotypes (A-C/G-C diplotype of rs6988339-rs3757930 frame, C-G/C-G diplotype of rs3757930-rs74942016 frame, and A-C-G/G-C-G diplotype of rs6988339-rs3757930-rs74942016 frame) associated with schizophrenia in our sample.

Conclusions

Our study indicated the associations of a SNP, a haplotype, and a diplotype of NRG1 with schizophrenia and supported the involvement of NRG1 gene in the development of the disease. Since our sample was collected from a limited geographic area, the associations we have reported need to be supported by further studies in different populations.
Ambiente hospitalario, funcionamiento familiar y afrontamiento activo como predictores de la adherencia al tratamiento farmacológico en pacientes con diabetes mellitus tipo 2
Authors: Torres Soto Nissa Yaing , Medina Fernández Josué Arturo , Rojas Armadillo María de Lourdes , Medina Fernández Isaí Arturo , Panting Villalobos Hugo Alejandro , Badillo Perry Saul David , Suárez Lara Gabriela Alejandrina
Published: May 2023

La diabetes mellitus tipo 2 (DMT2) representa un problema de salud pública en México por los altos índices de morbilidad y mortalidad debido a la falta de adherencia al tratamiento farmacológico. El objetivo fue analizar la adherencia al tratamiento farmacológico mediante un modelo de ecuaciones estructurales. A través de un estudio cuantitativo, no experimental, descriptivo, transversal y correlacional-explicativo, se trabajó con una muestra por conveniencia de 261 personas con DMT2 (64% mujeres y 36% hombres), con una media de 52.93 años y diagnóstico de DMT2 en Chetumal, Quintana Roo, México. El modelo estructural demostró que el ambiente hospitalario y el funcionamiento familiar tuvieron un efecto positivo y significativo en la adherencia al tratamiento farmacológico; a su vez, estos dos factores de segundo orden mediaron la adherencia al tratamiento farmacológico a través de las estrategias de afrontamiento activo.
ODETTE ERNEST DIAS: A PEDAGOGIA DA AUSÊNCIA DE SISTEMA
Authors: Costa d'Avila Raul
Published: May 2023

Esta apresentação ao VI SIGAM é uma adequação do capítulo III (Odette: discurso e percurso) de minha tese “ODETTE ERNEST DIAS: discursos sobre uma perspectiva pedagógica da flauta”, apresentada ao Programa de Pós-Graduação em Música da Escola de Música da Universidade Federal da Bahia, com apoio da CAPES através de uma bolsa do Programa Demanda Social. Defendida em abril de 2009, a tese teve como orientador o Prof. Dr. Lucas Robatto e coorientador o Prof. Dr. Joel Barbosa. Ela se propõe a proporcionar o leitor uma panorâmica do percurso de vida da flautista, na tentativa de desvelar, através de seu discurso repleto de questionamentos, filosofar como ela chegou ao ensino, se tornou professora, promovendo um sistema de ensino que é, “se é que existe”, como ela mesma disse, “justamente a ausência de sistema”. Constatei uma perspectiva pedagógica composta por respeito, flexibilidade, expressão própria e incentivo ao questionamento, que exerceu uma influência expressiva sobre o comportamento de seus alunos, tornando-os profissionais caracterizados pela diversidade, enquanto flautistas, e pela comunhão de sentimentos, linha de pensamento e atuação, enquanto professores.Palavras-chave: Odette Ernest Dias; Ensino de flauta; Pedagogia musical. ODETTE ERNEST DIAS: THE PEDAGOGY OF SYSTEM ABSENCE Abstract: This presentation to VI SIGAM is an adaptation of chapter III (Odette: dis­course and path) of my thesis “ODETTE ERNEST DIAS: discourses on a pedagogical perspective of the flute”, presented to the Graduate Program of Music of the School of Music from the Federal University of Bahia, supported by a CAPES Scholarship grant from the Social Demand Program. Defended in April 2009, the thesis was advised by Prof. Dr. Lucas Robatto and cosupervisor Dr. Joel Barbosa. It proposes to provide the reader with an overview of the flutist's life journey, in an attempt to un­veil, through Odette’s questioned-filled discourse, and philosophizing on how she came to teaching and became a teacher, promoting a teaching system, that is, “if there is", as she has said, "precisely the absence of a system". I found a pedagogical perspective composed of respect, flexibility, self expression and incentive to questioning, which exerted great influence on the behavior of her students, making them pro­fessionals characterized by diversity, as flutists, and by sharing feelings, a line of thought and action, as  teachers.Keywords: Odette Ernest Dias; Teaching the flute; Musical pedagogy.
PARTE DE UN PROCESO: GRABADO VERDE, UNA TÉCNICA QUE ME INVITA A LA CREACIÓN
Authors: Mirauda Peralta Maria Angelica
Published: May 2023

Resumem: En este ensayo visual, María Angélica Mirauda Peralta comparte elproceso creativo de su técnica de Grabado Verde. Palabras clave: Proceso creativo; Grabado Verde; Grabado no tóxico.PARTE DE UM PROCESSO: GRAVURA VERDE, UMA TÉCNICA QUE ME CONVIDA À CRIAÇÃOResumo: Neste ensaio visual, Maria Angelica Mirauda Peralta compartilha oprocesso criativo de sua técnica Gravura Verde. Palavras-chave: Processo criativo; Gravura Verde; Gravura não tóxica.PART OF A PROCESS: GREEN PRINTMAKING, A TECHNIQUE THAT INVITES ME TO CREATION Abstract: In this visual essay, Maria Angelica Mirauda Peralta shares the creative process of her Green Printmaking technique.Keywords: Creative process; Green Printmaking; Nontoxic printmaking.
Deleuze e a arte: uma leitura da obra de Anne Sauvagnargues
Authors: Raniere da Silva Édio
Published: May 2023

O presente trabalho oferece uma leitura sobre o tratamento dado porAnne Sauvagnargues aos processos de criação em Deleuze et l’art. Ao tomar oconceito de bloqueio e a noção de subtração como formuladores de tais processoso ensaio é levado à crítica que a filosofia da diferença realiza ao primado do sujeito.Na tentativa de compreender a relação entre esta crítica e os processos de criaçãoprepara uma composição de três imagens: desejo, individuação, linha de fuga. Porfim, a partir de uma conhecida análise de Franz Kafka busca aproximar tais imagensdo agenciamento inicialmente proposto entre bloqueio, subtração e criação.Palavras-chave: Deleuze; Arte; Anne Sauvagnargues; Processos de Criação.  Résumé: Le présent ouvrage propose une lecture sur le traitement donné par Anne Sauvagnargues aux processus de création dans Deleuze et l'art. En prenant le concept de blocage et la notion de soustraction comme formulateurs de tels processus, l'essai est porté à la critique que la philosophie de la différence fait a le primat du sujet. En vue de comprendre la relation entre cette critique et les processus de création, il prépare une composition de trois images: le désir, l'individuation, la ligne de fuite. Enfin, à partir d'une analyse bien connue de Franz Kafka, il cherche à rapprocher ces images de l'agencement initialement proposée entre blocage, soustraction et création. Mots-clés: Deleuze; Art; Anne Sauvagnargues; Processus de création
Deleuze e a música: modos de criar no curso de Bacharelado em Música Popular da UFPel
Authors: Barros de Borba Marcelo
Published: May 2023

O presente trabalho problematiza os modos de pensar a criação no curso de bacharelado em música popular da Universidade Federal de Pelotas-RS. Operando a partir da perspectiva da filosofia da diferença (DELEUZE, 2010; 1999; 2009), a música e a filosofia deleuziana ocupam um lugar de pensamento e ativação artística. São propostas alianças com filósofos e compositores como Tom Zé para abordar a prática de conjunto e a constituição de bandas.Palavras-chave: Filosofia da diferença; Criação musical; Bacharelado em música popular.Deleuze and music: ways to create at the Bachelor’s course in Popular Music at UFPelAbstract: The present investigation discusses ways of thinking about creation in the Bachelor's course in Popular Music at the Federal University of Pelotas-RS, Brazil. Operating from the perspective of the philosophy of difference (DELEUZE, 2010; 1999; 2009), music and Deleuzian philosophy occupy a place of reflection and artistic activation. Alliances are proposed with philosophers and composers like Tom Zé to address ensemble practice and the constitution of bands.Keywords: Philosophy of difference; Music creation; Bachelor's degree in popular music.
Global Infectious Diseases in April 2023: Monthly Analysis
Authors: Wu Yufan , Zou Jiazhen , Sun Yinfu , Xiang Qi , He Minjing , Zhang Shuqiong , Liu Dongliang , Li Guodan , Li Taihan , Luo Yi , Su Qun , He Shiping , Yu Wenjin , Gu Dayong
Published: May 2023

Thousands of years have passed since infectious diseases first endangered human health as the most potentially lethal and debilitating diseases worldwide. The global incidence of infectious diseases has increased significantly over the past decades, such as COVID-19, cholera, dengue, and influenza. Key elements in combating and controlling diseases include monitoring and reporting infectious disease timelines and geographic distribution. We obtained surveillance data from Shusi Tech’s Global Epidemic Information Monitoring System and comprehensively analyzed the timing and location of outbreaks in infected populations from 24 March 2023 to 23 April 2023. Recent worldwide outbreaks of infectious diseases highlight the need to implement effective monitoring strategies and warning systems.
Rab11a Is Essential for the Development and Integrity of the Stereocilia and Kinocilia in the Mammalian Organ of Corti
Authors: Knapp Lindsey , Sun Haojie , Wang Yan-Mei , Chen Bin-Jun , Lin Xi , Gao Nan , Chen Ping , Ren Dongdong
Published: May 2023

The cochlea hair cells transform mechanic sounds to neural signals with a remarkable sensitivity and resolution. This is achieved via the precisely sculpted mechanotransduction apparatus of the hair cells and the supporting structure of the cochlea. The shaping of the mechanotransduction apparatus, the staircased stereocilia bundles on the apical surface of the hair cells, requires an intricate regulatory network including planar cell polarity (PCP) and primary cilia genes in orienting stereocilia bundles and building molecular machinery of the apical protrusions. The mechanism linking these regulatory components is unknown. Here, we show that a small GTPase known for its role in protein trafficking, Rab11a, is required for ciliogenesis in hair cells during development in mice. In addition, in the absence of Rab11a, stereocilia bundles lost their cohesion and integrity, and mice are deaf. These data indicate an essential role of protein trafficking in the formation of hair cell mechanotransduction apparatus, implicating a role of Rab11a or protein trafficking in linking the cilia and polarity regulatory components with the molecular machinery in building the cohesive and precisely shaped stereocilia bundles.
Oh Deer … Practicing Scientific Inquiry and Data Literacy through an Authentic Gazelle Data Set
Authors: Bar Carmel , Yarden Anat
Published: May 2023

Large data sets invite students to engage in scientific practices such as question asking, identifying correlations, using visualizations, and practicing data literacy in an authentic context. However, authentic data sets are rarely introduced in the biology classroom. We prepared an online inquiry activity based on authentic gross characteristics of a gazelle data set. These included gazelle’s weight, location (longitude and latitude), collection date, and measured lengths of body parts. In constructing the activity, we considered the following design principles: use of high-quality authentic data, choice of a wide data set to allow multiple research questions, and exposure of the participants to basic data science tools. The activity starts with an introduction to data sets and guided data analysis, and it ends with independent research of a large gazelle data set. The activity was experienced by 121 teachers and was found to promote higher-order research questions. Before the activity, most of the teachers’ questions focused on gazelle properties—first-order questions, according to Dillon’s (1984) classification of research questions. Following the activity, most questions belonged to the comparison and contingencies categories (second- and third-order questions, respectively). Thus, this activity might serve to expand the biology teacher’s toolbox in teaching inquiry and data literacy.
Development of an RGB Color Sensor & Its Application to Determine Urease Activity with Students at School
Authors: Derman Mustafa
Published: May 2023

New laboratory activities have been developed to improve students’ scientific process skills. With the development of technology, teachers and students have the opportunity to use the new activities in their lessons. In this research, an Arduino-based activity was developed and then tested with different experiments. Students had the opportunity to practice some types of scientific process skills with regard to scientific facts (determining effects of variables; collecting data; measuring, reporting, and interpreting findings; and discussing possible reasons).
Legal Counseling Making Waste a Resource at the Mustika Jaya Garbage Bank
Authors: Siombo Marhaeni Ria
Published: May 2023

Law No.18/2008 concerning Waste Management is already thirteen years old, which has taken a long time to serve as a legal basis for resolving various waste cases, which are still a social problem, including in Bekasi City. In this law, the aim of waste management is to turn waste into a resource, which until now has not been fully implemented properly. In terms of the intent of the legislators is to minimize the accumulation of waste that interferes with aesthetics and public health. This article is related to community service activities carried out at one of the waste banks in the city of Bekasi. The purpose of community service in the form of legal counseling to the Wijaya Mustika Garbage Bank, Mustikajaya Village, Bekasi City is to provide education about the aims and objectives of the Garbage Bank program. A waste bank is an effective form of community participation in managing waste as a 'resource'. The problem is educating the public about turning waste into a resource, not accompanied by an understanding that the true purpose of waste management is to improve and maintain the quality of the environment in order to achieve a better quality of human life. Using waste as a resource as a 'means' to increase public awareness is not the ultimate goal of environmental management. Environmental education or environmental counseling needs to be carried out continuously, so that awareness arises and eventually it becomes a habit or 'culture' or trend of healthy living, without waste.
Legal Aspect on Packaging and Marketing Strategy for Traditional Salt Products in Les Village, Tejakula District, Buleleng Regency
Authors: Mangku Dewa Gede Sudika , Yuliartini Ni Putu Rai , Suarmanayasa I Nengah , Nur Irwan , Jodi Setianto Muhamad
Published: May 2023

The objectives of this community service activity are: 1) Making a trademark and being registered with HKI as self-identity in marketing salt products. 2) Train skills in traditional salt packaging. 3) Train skills in product marketing through market place and social media. The target audience in this service is the Tasik Segara 1 Group, Les Village. The implementing team chose the mentoring method as the method in carrying out this community service activity. The stages in the implementation of this assistance are adjusted to the issues raised and the needs of partners. The result of this activity is that partners have knowledge of trademarks and the Intellectual Property Rights registration process, and partners have trademarks related to the Les Village traditional salt processed product, namely "Uyah Les", partners have their own packaging designs and partners have skills in packaging traditional Village salt products Les, and partners are able to implement marketing management through market place and social media, and partners have market place and social media management.
Socialization Regarding Community Rights to Company Obligations in Lempuyang Bandar Village, Central Lampung
Authors: Natamiharja Rudi , Fakih Muhammad , Patra Elman Eddy , Saputra Muhammad Febriyan
Published: May 2023

Perusahaan memiliki tanggung jawab sosial (CSR) kepada masyarakat. Akan tetapi, masyarakat tidak sepenuhnya mengetahui dan memahami prosedur untuk mengakses CSR tersebut. Maka dari itu, dalam mewujudkan masyarakat desa yang berwawasan akan haknya, peneliti menganggap pelaksanaan sosialisasi mengenai peningkatan pemahaman masyarakat sangatlah penting demi keberlangsungan dan kenyamanan hidup  warga  setempat. Metode pelaksanaan yang digunakan dalam pengabdian kepada masyarakat ini adalah melalui Sosialisasi   dan   diskusi, pendampingan kegiatan-kegiatan dalam memperjuangkan hak masyarakat kepada pihak perusahaan, serta penjelasan dan edukasi kepada masyarakat terkait tata cara apabila hak dan kewajibannya tidak diperoleh oleh perusahaan. Kegiatan pengabdian ini telah memberikan dampak kepada masyarakat khususnya di Desa Lempuyang Bandar, Lampung Tengah. Masyarakat menjadi paham akan pentingnya hak mereka, khususnya dalam menerima tanggungjawab sosial perusahaan (CSR).
Revisiting tradition in Ahmad Fuadi’s Anak Rantau
Authors: Wardani Elisa Dwi , Adi Ida Rochani , Pujiharto Pujiharto
Published: May 2023

Paradoxical as it may be, Anak Rantau both problematizes the practice of outmigration tradition in Minangkabau culture, yet campaigns for the perpetuation of Minangkabau tradition at the same time. By highlighting the darker side of the impact of outmigration, the novel advises returning to the religion-based tradition which works through the revitalization of the surau, as a learning center, and less-materially oriented outmigration for remedy. Although it is apparent that the meaning of outmigration is being rearticulated in the novel, it is also inevitable to notice that the novel perceives the ecological destruction, the waning tradition, and the spiritually corrupt village as a failure of modernity, creating a learning loss among the Minangkabau’s youngsters. This paper uses Bhabha’s perspective of modernity and his theory of the Third Space of enunciation to reveal how the meaning of outmigration has been rearticulated in the novel and how it intersects with the powerful discourse of modernity. This paper tries to show that, first of all, in the attempts to rearticulate the long institutionalized outmigration tradition of Minangkabau people by questioning the virtue of its materialistic orientation, and problematizing the concept of ‘home’ and ‘rantau’, the novel actually tries to closely adhere to the Minangkabau tradition. Secondly, it also tries to show that the problem of learning loss is pronounced well in the anxieties over the undermining of Minangkabau traditional values.
Lexical verbs of hedging in English research articles by native and non-native speakers
Authors: Budiarti Dian , Hardjanto Tofan Dwi , Faris Ihsan Nur Iman
Published: May 2023

This study aims to compare verb variation and the functions of hedges used in English scientific research articles written by English native speakers (NS) and non-native speakers from Indonesia (NNS). The data were collected from a corpus of 30 international journal articles. The analysis was conducted quantitatively using a normalization system and statistical tests to determine the frequency and distribution of lexical verbs and qualitatively using Palmer’s (2001) and Hyland’s (1996) hedging model to identify the forms and specific functions of the hedges. The findings demonstrate that both NS and NNS used speculative, deductive, quotative, and sensorial verbs as hedges. However, NS used speculative and sensorial verbs more frequently, while NNS used deductive and quotative verbs more frequently. Statistically, the frequency and distribution of hedges in the two categories of writers were not significantly different. Both NS and NNS tend to use lexical verbs to protect themselves as writers by limiting personal commitments and to protect their readers by anticipating rejection based on subjectivity. These findings contribute to the understanding of hedging use in academic writing by NNS from Indonesia and provide implications for English language teaching and learning.
MicroRNAs as regulators of tumor metabolism
Authors: Ruggieri Francesca , Jonas Katharina , Ferracin Manuela , Dengler Michael , Jӓger Vanessa , Pichler Martin
Published: May 2023

Cancer cells reprogram their metabolism to support their growth. Since the discovery of the Warburg effect, several other metabolic alterations and metabolites have been described in cancer cells, including lactate, glutamine, and lipid metabolism reprogramming. Together these alterations provide rapidly dividing tumor cells with metabolic intermediates needed for nucleotide, protein, and fatty acid biosynthesis. MicroRNAs are a class of small non-coding RNAs involved in the regulation of virtually all biological pathways. Altered microRNA expression patterns are associated with the onset and development of several diseases, including cancer. Tumor suppressor microRNAs targeting molecules involved in tumor metabolism are frequently downregulated in cancers. Therefore, microRNAs can serve as potential tumor biomarkers and also represent interesting therapeutic targets. This review summarizes recent findings about microRNAs involved in the regulation of tumor metabolism.
On the peculiarities of using sparse matrices in problems of mathematical modeling
Authors:   Glushkov Institute of Cybernetics NAS of Ukraine, Khimich O.M. , Popov A.V. ,   Glushkov Institute of Cybernetics NAS of Ukraine, Chystiakov О.V. ,   Glushkov Institute of Cybernetics NAS of Ukraine
Published: May 2023

Mathematical modeling and the related computer experiment are now one of the main means of studying objects, processes and phenomena of various nature: in science, engineering, economics, society, etc. A significant improvement in the quality of mathematical modeling in many areas of science and engineering is possible only with the use of fundamentally new three-dimensional models, the transition from computer simulation of individual components and assemblies to the calculation and optimization of the product as a whole. It is obvious that the consideration of problems in such a formulation leads to discrete mathematical models of super-large sizes. Existing supercomputers of different parallel architectures make it possible to efficiently solve such problems. However, the time for solving problems on parallel computers consists of the time of the actual solution and the time of performing additional operations, that are necessary for the exchange of information between computing devices, that is overhead costs. This is especially true for problems of linear algebra with different structures of sparse matrices of large volumes, that arise in the mathematical modeling of processes. Sparse matrix compaction schemes, decomposition of data arrays between processors are one of the main factors for the effective solution of these problems on parallel computers. The paper considers efficient methods for processing sparse matrices of arbitrary structure for the purpose of effective mathematical modeling of structural strength problems on parallel computers. Various methods of regularization and decomposition of sparse matrices of arbitrary structure, efficient data storage schemes, technology for studying the conditionality of a matrix with approximate data on a computer are proposed. This way of using sparse matrices in mathematical modeling ensures more efficient use of computing resources and reliability of computer results. Problems of mathematical modeling are presented, where the considered methods of processing sparse matrices were effectively applied.
The concept and evaluating of big data quality in the semantic environment
Authors:   Institute of Software Systems NAS of Ukraine, Novitsky A.V.
Published: May 2023

Big data refers to large volumes, complex data sets with various autonomous sources, characterized by continuous growth. Data storage and data collection capabilities are now rapidly expanding in all fields of science and technology due to the rapid development of networks. Evaluating the quality of data is a difficult task in the context of big data, because the speed of semantic data reasoning directly depends on its quality. The appropriate strategies are necessary to evaluate and assess data quality according to the huge amount of data and its rapid generation. Managing a large volume of heterogeneous and distributed data requires defining and continuously updating metadata describing various aspects of data semantics and its quality, such as conformance to metadata schema, provenance, reliability, accuracy and other properties. The article examines the problem of evaluating the quality of big data in the semantic environment. The definition of big data and its semantics is given below and there is a short excursion on a theory of quality assessment. The model and its components which allow to form and specify metrics for quality have already been developed. This model includes such components as: quality characteristics; quality metric; quality system; quality policy. A quality model for big data that defines the main components and requirements for data evaluation has already been proposed. In particular, such evaluation components as: accessibility, relevance, popularity, compliance with the standard, consistency, etc. are highlighted. The problem of inference complexity is demonstrated in the article. Approaches to improving fast semantic inference through materialization and division of the knowledge base into two components, which are expressed by different dialects of descriptive logic, are also considered below. The materialization of big data makes it possible to significantly speed up the processing of requests for information extraction. It is demonstrated how the quality of metadata affects materialization. The proposed model of the knowledge base allows increasing the qualitative indicators of the reasoning speed.