bluuebunny/crossref_metadata_2025 huggingface dataset:
FIRST DESCRIPTION OF ANTIBACTERIAL AND IN VITRO WOUND HEALING PROPERTIES OF COCOS NUCIFERA TOMENTUM
Authors: HARITHA KH  , SUJITHA KUTTINATH  , RAM RAMMOHAN
Published: October 2019

Objective: The objective of the study was to evaluate the antibacterial, antioxidant, and in vitro wound healing property of Cocos nucifera tomentum.
Methods: Ethanolic and methanolic extracts of C. nucifera tomentum were prepared using the Soxhlet extraction method and aqueous extract was prepared by the shaker flask method. These extracts were investigated for the phytochemical profile by gas chromatography and mass spectroscopy (GC-MS) and liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-Q-ToF MS), for antibacterial activity by microdilution method, for the antioxidant property by 2,2-diphenyl-1-picrylhydrazyl assay, and for in vitro wound healing activity on cell lines.
Results: The preliminary phytochemical screening showed the presence of alkaloids, flavonoids, and various bioactive components. GC-MS and LC-Q-ToF MS analysis of extracts revealed the presence of bioactive compounds known to have wound healing properties as well as antioxidant and antimicrobial activities. The methanolic extract had better antibacterial activity against Proteus vulgaris and Escherichia coli, and better antioxidant and wound healing activity, when compared to the ethanolic and aqueous extracts.
Conclusion: The present study suggests that C. nucifera tomentum might be a potential therapeutic source for topical antibacterial and wound healing applications.
DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL OF KAEMPFERIA GALANGA L EXTRACT AS AN ANTI-INFLAMMATION (PROSTAGLANDIN E2 AND TUMOR NECROSIS FACTOR ALPHA) ON OSTEOARTHRITIS
Authors: NURPUDJI A TASLIM  , M NATSIR DJIDE  , YUSNITA RIFAI  , AKMAL NOVRIAN SYAHRUDDIN  , YOSEFA RIA RAMPO  , MURNI MUSTAMIN  , SIGIT ANGRIAWAN
Published: October 2019

Objective: The purpose of this study was to compare the effectiveness of the rhizome extract against inflammatory markers such as tumor necrosis factor (TNF)-alpha and prostaglandin E2 (PGE2) with meloxicam in patients with osteoarthritis at knee.

Materials and Methods: This study designed two phases as follows: The preparation of rhizome extract in a capsule dosage form which was then followed by double-blind clinical trials, randomized controlled, pre- and post-test design (18 cases) using the WOMAC scores for pain, to markers of inflammation using an enzyme-linked immunosorbent assay method.

Results: The results did not reveal any significant differences in pain scores, stiffnesses, and physical function impairment between the intervention (the rhizome extract) and control groups (meloxicam), it either did not reveal any significant differences in the parameters of inflammatory marker TNF alpha and PGE2 among the groups.

Conclusion: The rhizome extract had the same effect on pain, stiffness, physical interference as meloxicam, and on PGE2 as well as on the inflammatory marker TNF-alpha. Therefore, this extract can be used as an alternative herbal medicine for osteoarthritis.
EFFECTS OF ETHANOL CINCAU (CYCLEA BARBATA MIERS) LEAVES EXTRACT ON MACROPHAGE MIGRATION ON BURN WOUND
Authors: DINA DEWI S L I  , WIBI RIAWAN  , IKA SETYO RINI  , TITIN ANDRI WIHASTUTI  , IKA FITRI APRILIANTI  , RETTY RATNAWATI  , HANDONO KALIM  , KARYONO MINTAREOM  , LOEKI ENGGAR FITRI
Published: October 2019

Objective: Macrophages are essential cells in burn wound healing. The primary function of macrophages is phagocytosis of microbes and necrosis tissue. Migration of macrophages into the wound area is affected by interleukin-1 (IL-1). Ethanol extract of Cincau or green grass jelly leaves or Cyclea barbata Miers contains pectin, flavonoids, and alkaloids. These compounds influence the inflammatory process. The purpose of this study was to reveal the effect of ethanol Cincau leaves extract on the expression of IL-1 and the number of macrophages in second degree burn wounds tissue.

Methods: This study used 30 rats divided into six groups based on different treatments: NaCl 0.9% (K), silver sulfadiazine/(SSD) (P1), hydrogels (P2), Cincau extract 40% (P3), Cincau extract 50% (P4), and Cincau extract 60% (P5). Treatment was conducted over 4 days. On the 5th day, burn wounds tissues were taken, then immunohistochemistry staining was applied.

Results: One-way ANOVA test on the expression of IL-1 showed a difference among groups (p<0.05) and on the number of macrophages (p<0.05). Post hoc tests on the expression of IL-1 showed Cincau extracts 40% and 50% treated-groups significantly differ with the NaCl 0.9% group but not with hydrogel treated group. The similar result showed Cincau extracts 40% and 50% treated-groups significantly differ from the control group but not with SSD and hydrogel groups.

Conclusions: It can be concluded that ethanol extract of Cincau leaves can decrease IL-1 expression and increase the number of macrophages which have an important role in inflammation resolution of burn wounds.
EVALUATION OF ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECT OF VERNONIA DIVERGENS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Authors: LAXMIDHAR MAHARANA  , MANOJ KUMAR SETHI  , RUDRA NARAYAN DASH  , SNIGDHA PATTNAIK
Published: October 2019

Objective: The current investigation for antidiabetic activity of the plant Vernonia divergens (DC.) Edgew. has not been reported till date. However, to enlighten the folkloric claim of the plant, the study was carried out on various animal models such as albino mice, albino rabbits, Wistar rats, rabbits, hamsters, dogs, and monkeys.

Methods: The whole plant of V. divergens was studied on various animal models. Screening methods generally have been carried out on rodents and non-rodents, respectively. Various biochemical and hematological parameters such as serum glucose, plasma insulin, lipid profile and activities of liver enzymes, red blood cells, white blood cells, hemoglobin, and differential counts were measured to assess the antihyperglycemic and antihyperlipidemic activities as well as safety profile of the extract.

Results: Among all experimental extracts of V. divergens, it was found that the aqueous and methanolic extracts had maximum control of blood glucose in diabetic Wistar rats. While comparing with normoglycemic animals, it was observed that reduction of blood sugar level and increase in plasma insulin level are maximum with test extract. Among the study, the effects of the methanolic extract of V. divergens (MEVD) and aqueous extract of V. divergens (AEVD) were done through oral route in both the models, i.e., normoglycemic and hyperglycemic animal models. The safety profile was evaluated by toxicological evaluation and observed that, even at a higher dose level of 3000 mg/kg body weight, the MEVD and AEVD were safe and retain normal physiological and behavioral effect. The whole protein, whole cholesterol, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase enzyme activity of streptozotocin-administered rats showed significantly higher than normal rats, and the test extract-treated rats significantly reduced the elevated levels.

Conclusion: It is concluded that the MEVD and AEVD (DC.) Edgew. might be beneficial in effectively reducing the blood glucose concentration and managing the various complications of diabetes. However, in comparison between both the extracts, the methanol extract was found to be significantly more potent than that of the A.E. in all aspects.
ANTI-INFLAMMATORY ACTIVITY OF METHANOL EXTRACT OF NIEBUHRIA APETALA (ROTH) DUNN – IN VITRO MODELS
Authors: RAJESH A  , DOSS A  , TRESINA PS  , MOHAN VR
Published: October 2019

Objective: The objective of this study was to determine the anti-inflammatory activity of methanol extract of Niebuhria apetala and its possible mechanism of action.

Methods: Methanol extract of Niebuhria apetala leaf (NAL) was assessed for its anti-inflammatory activity by in vitro methods. Using albumin denaturation assay, proteinase inhibitory activity, membrane stabilization, and antilipoxygenase activity at different concentrations, in vitro anti-inflammatory activity was estimated. The standard drug used for this purpose was aspirin.

Results: Methanol extract NAL at a concentration range of 100–500 μg/ml significant (p<0.01) protects the heat-induced protein denaturation. At the concentration of 500 mg/ml, NAL showed significant (p<0.01) inhibition of protease inhibitory action. Heat-induced hemolysis of erythrocyte, hypotonicity-induced hemolysis, and lipooxygenase activity were significant (p<0.01) inhibited at the concentration of 500 μg/ml.

Conclusion: Finally, the present study indicates that methanol extract of Niebuhria apetala can be a potential source of anti-inflammatory agent.
IN VITRO-IN VIVO CORRELATIONSHIP APPROACH OF THE PREPARED MAGNETIC MICROSPHERES OF CYTARABINE
Authors: SATINDER KAKAR  , ANUREKHA JAIN
Published: October 2019

Objective: The objective of this study was to study the in vitro-in vivo correlationship between the magnetic microspheres prepared by continuous solvent evaporation (CSE) method by 32 factorial designs.

Methods: CSE technique was used in the preparation of magnetic microspheres. Drug used was cytarabine and mice were the animal model used to check the correlationship.

Results: The profiles are nearly identical and reveal that drug absorption is rapid. The in vivo drug absorbed was found to be in concordance with the in vitro release as seen in the superimposable curves.

Conclusion: Cytarabine effectively reduces the amount of drug released and consequently absorbed in vivo in the initial phase.
A PRELIMINARY OBSERVATION ON AN EXPLICIT ANTIMICROBIAL ACTION OF MANGROVE PLANTS ON PSEUDOMONAS AERUGINOSA
Authors: TAMANNA SULTANA  , ARUP KUMAR MITRA  , SATADAL DAS
Published: October 2019

Objectives: Due to emerging drug-resistant microorganisms throughout the world, newer antimicrobial agents should be looked for. Plants are enriched with different bioactive chemicals. In this study, we searched antibacterial activities of some mangrove plant extracts against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli.

Methods: In the present study, the antimicrobial activity of the leaves of Bruguiera gymnorhiza, Excoecaria agallocha, Avicennia alba, and Aegialitis rotundifolia was evaluated against a few reference pathogenic bacterial strains, namely, P. aeruginosa ATCC 27853, E. coli ATCC 25922, S. aureus ATCC 29213, and multidrug-resistant bacterial strains E. coli extended-spectrum beta-lactamases strain. Aqueous, ethanolic, methanolic, and dimethyl sulfoxide (DMSO) extracts were studied. The antimicrobial activities of the organic solvent extracts on the various test microorganisms were investigated using agar well diffusion technique followed by determination of minimum inhibitory concentration values by serial dilution in a microtiter plate.

Results: Ethanol and DMSO extracts of B. gymnorhiza exhibited promising antimicrobial activity followed by extracts of A. alba and E. agallocha. Among all microorganisms studied, P. aeruginosa ATCC 27853 showed significant growth inhibition with ethanol and DMSO extracts.

Conclusion: Extracts of some mangrove plants, particularly, B. gymnorhiza showed very good antimicrobial activities against common microbial agents causing human infections and in general mangrove plants appear to act better on P. aeruginosa.
AN EXPERIMENTAL STUDY EVALUATING THE INFLUENCE OF QUERCETIN ON MONOSODIUM GLUTAMATE-INDUCED DEPRESSION IN SWISS ALBINO MALE MICE
Authors: SRIRAM BS  , RAVICHANDRA V
Published: October 2019

Objective: The objective of the study was to evaluate the antidepressant activity of quercetin in monosodium glutamate (MSG) model of depressed male mice.

Methods: MSG was administered (500 mg/kg) to different groups of albino male mice daily for 21 days to induce depression. The interventions (Quercetin and imipramine) were started on day 9th and continued till 21st day. On 23rd day, mice are sacrificed, hippocampus and amygdala supernatant are subjected for analysis. p<0.05 was considered as statistically significant.

Results: There was a statistically significant reduction in interleukin (IL)-6 levels in animals treated with quercetin and imipramine compared to control group (p<0.001). There was also a statistically significant increase in brain-derived neurotrophic factor (BDNF) levels in quercetin with MSG groups (p<0.05) and imipramine with MSG groups (p<0.01). There was no statistically significant difference in IL-6 and BDNF levels between the groups of animals treated with quercetin (100 mg/kg) and imipramine (10 mg/kg) alone.

Conclusion: Quercetin appeared to have an antidepressant activity. More extensive research is required to substantiate and elucidate the role of quercetin in behavioral disorders such as depression.
DEVELOPMENT, EVALUATION AND TARGETING OF STAVUDINE LOADED SERUM ALBUMIN POLYMER BASED NANOCARRIERS TO HIV RESERVOIRS
Authors: JENITA J JOSEPHINE LENO
Published: October 2019

Objective: Stavudine is an antiretroviral drug that is part of the nucleoside reverse transcriptase inhibitor (NRTIs) family, which is used to delay the progression of HIV infection. The present investigation involves the development and evaluates stavudine loaded nanocarriers using natural polymer bovine serum albumin (BSA).

Methods: The desolvation technique was used to prepare nanoparticles and coated with 1% v/v polysorbate 80 to improve the targeting of drugs to the organs (HIV reservoirs). Biodistribution studies were also investigated for the best formulation to determine the targeting efficiency of nanocarriers loaded stavudine and compared with pure compound.

Results: The formulated nanocarriers have shown mean particle size below 300 nm, zeta potential in the range of -16.5 Mv, encapsulation efficiency in the range of 50.10 to 73.7%, drug loading in the range of 14.73 to73.84%. Cumulative % drug release was in the range of 24.72 to 71.20% and release kinetics studies showed that the mechanism of drug release was controlled simultaneously by diffusion and erosion of the matrix type formulations. The stability studies over a period of three months confirmed the stability of BSA nanoparticles. Biodistribution studies demonstrated that nanoparticles coated with 1% v/v polysorbate 80 were able to reach the HIV reservoirs in an amount higher than that of uncoated stavudine nanoparticles or pure drug itself.

Conclusion: The method adopted is simple and the biodistribution studies demonstrated that nanoparticles coated with 1% polysorbate 80 were able to reach the selected organs in an amount higher than that of uncoated stavudine nanoparticles or pure drug itself.
GENETIC SUSCEPTIBILITY OF TRANSCRIPTION FACTOR 7-LIKE 2 GENE VARIANT AND RISK OF TYPE 2 DIABETES IN ASIAN INDIANS
Authors: NAVNEET KAUR  , GURJIT KAUR BHATTI  , SANJAY KUMAR BHADADA  , SAMER SINGH  , JASVINDER SINGH BHATTI
Published: October 2019

Background: The variants of transcription factor 7-like 2 (TCF7L2) gene have been shown to be associated with type 2 diabetes mellitus (T2DM) and its related complications.

Objectives: We aimed to explore the possible association of rs7903146 (C/T) variant in TCF7L2 with the risk of T2DM in the North Indian population.

Methods: The present case–control study included a total of 638 human subjects (318 T2DM subjects and 320 healthy controls). Various anthropometric, biochemical, and genetic parameters were studies in all the subjects. Genotyping of TCF7L2 gene was carried out using allele-specific polymerase chain reaction method.

Results: The results of this study indicate significantly higher values of body mass index, waist circumference, waist-to-hip ratio, and body fat (%) in T2DM subjects than controls (p≤0.001). Dyslipidemia represented by higher levels of triglycerides and reduced values of high-density lipoprotein was more predominant in diabetic subjects compared to healthy subjects. The frequency of risk genotype (TT) frequency was significantly higher in T2DM subjects (16.4%) compared to controls (11.6%). The “T” allele was more dominant in diabetic subjects than controls. Logistic regression analysis of the data revealed a significant association of TT genotype with 2-fold (odds ratio with 95% of confidence interval; 2.09 [1.29–3.42] p=0.003) and CT genotype with 1.7-fold (1.73 [1.23–2.44] p=0.002) increased risk of developing T2DM.

Conclusions: The present study demonstrated a significant association of rs7903146 (C/T) variant in TCF7L2 with the augmented risk of T2DM in North Indian population.
Médicos científicos y medicos ilícitos en la ciudad de México durante el porfiriato
Authors: AGOSTONI CLAUDIA
Published: October 2019

DURING LATE NINETEENTH CENTURY MEXICO CITY, UNIVERSITY TRAINED PHYSICIANS ATTEMPTED TO DOMINATE THE PRACTICE OF MEDICINE AND TO DIFERENTIATE THEMSELVES FROM WHAT THEY CONSIDERED TO BE OLLEGAL COMMUNITY AND THE SHARED VALUES OF THEIR SCIENTIFIC EDUCATION AND SOCIAL DISTINCTION THEY WANTED TO SEE IN PLACE BETWEEN THEMSELVES AND THE ´ OTHER´ WAS DIFFICULT TO DEFINE, AND EVEN MORE SO TO ENFORCE. THIS ARTICLE SEEKS TO SHED LIGHT ON THE EMPHASIS OF THE MEDICAL COMMUNITY TO DISTINGUISH BETWEEN SCIENTIFIC AND POPULAR MEDICINE DURING PORFIRIAN MEXICO.
La prensa opositora al maderismo, trinchera de la reacción. El caso del periódico El mañana
Authors: MÉNDEZ REYES JESÚS
Published: October 2019

EL ARTÍCULO ANALIZA LA OPOSICIÓN POLÍTICA AL RÉGIMEN DE FRANCISCO I. MADERO (1911-1913) A TRAVÉS DE LA PRENSA DE LA ÉPOCA, ESPECÍFICAMENTE EL PERIÓDICO EL MAÑANA, CUYO DIRECTOR JESÚS M. RABAGO PERTENECIÓ A LA ALTA ARISTOCRACIA QUE AÑORABA LA VUELTA DE PORFIRIO DÍAZ Y AL ASCENSO DE VICTORIANO HUERTA FUNGIÓ COMO SU SECRETARIO PARTICULAR. SE MUESTRA EL MANEJO DE ALGÚN SECTOR DE LA OPINIÓN PUBLICA A TRAVÉS DE LA DIATRIBA Y EL CONSTANTE ATAQUE A LA ADMINISTRACIÓN MADERISTA FRENTE A SUS DESACIERTOS Y DEBILIDADES. HAY UN CUADRO, RESUMEN DE ALGUNAS PUBLICACIONES DE ESTOS AÑOS, QUE REFLEJA EL GRADO DE POLITIZACIÓN DE LOS LECTORES DE DIARIOS Y REVISTAS EN LA CIUDAD DE MÉXICO Y LA INSERCIÓN DE ALGUNOS TEXTOS QUE EJEMPLIFICAN LA SÁTIRA Y EL DESPRECIO CON QUE SE REFIRIÓ LA REACCIÓN MEXICANA A LA PRIMERA ADMINISTRACIÓN DEMOGRÁFICA DEL PAÍS.
El Iris. Periódico crítico y literario
Authors: CLAPS ARENAS MARÍA EUGENIA
Published: October 2019

ESTE ARTÍCULO PRESENTA UNA SÍNTESIS DE LAS CARACTERÍSTICAS GENERALES Y LA TRASCENDENCIA DE EL IRIS, LA PRIMERA REVISTA LITERARIA DE MÉXICO INDEPENDIENTE, QUE APARECIÓ ENTRE FEBRERO Y AGOSTO DE 1826. EN EL TRABAJO SE DA LA IMPORTANCIA QUE ESTA PUBLICACIÓN MERECE DENTRO DE LA CULTURA DECIMONÓNICA DE NUESTRO PAÍS. SU CONTENIDO MUESTRA NO SOLO LA GRAN INFLUENCIA DE EUROPA QUE PRIVABA EN AQUELLA ÉPOCA EN EL ÁMBITO CULTURAL SINO TAMBIÉN, Y DE MANERA MUY PATENTE, LAS INQUIETUDES POLÍTICAS Y LOS INTERESES QUE SE MOVÍAN EN MÉXICO DE AQUELLOS AÑOS. POR TODO ESTO, EL IRIS RESEÑA UNA ÉPOCA Y CONSTITUYE UN MATERIAL HISTÓRICO FUNDAMENTAL PARA ACERCARSE A LAS CARACTERÍSTICAS DE LA PRIMERA REPUBLICA FEDERAL EN MÉXICO.
Experimental study of the operation of the bolt joint of a bearerwith a column in precast-monolithic ceiling
Authors: Koyankin Aleksandr Aleksandrovich , Mitasov Valeriy Mikhaylovich
Published: October 2019

Precast-monolithic construction is becoming an increasingly popular form of housing. The wide distribution of this type of construction is explained by the possibility to successfully combine the advantages of precast and monolithic construction, at the same time reducing their disadvantages. Though there is a significant lack of data, including experimental data, for objective assessment of the stress-strain state of precast-monolithic floor structures. In order to investigate the structural reliability of the bolt joint of a bearer with a column in a precast-monolithic building a series of experimental investigations were carried out in the laboratory of testing the building structures of the Siberian Federal University.One of the main conclusions is that the bolt joint of a bearer with a column is characterized by sufficient rigidity, crack resistance and bearing capacity. The results of the given work have proved the data obtained in previously conducted investigations on a fragment of a precast-monolithic ceiling.
Elements of accounting in the context of the balanced scorecard construction enterprise
Authors: Patrina Tat’yana Konstantinovna , Chekunova Aleksandra Sergeevna
Published: October 2019

No doubt that the accounting information in financial and economic life of society is very significant. The actions of economic agents depend on the quality and completeness of the accounting information. An accounting policy of an enterprise is a certain system of ways of accounting, which is approved by the enterprise to help all concerned to get full and correct accounting information. Making solutions on the basis of key performance indicators gives opportunity to analyze the minimal number of quantitative indexes essential for an enterprise, which reflect the degree of achieving the stated goals. The key indicators are the indicators of performance efficiency of both the departments and the enterprise as a whole. A balanced system of indicators helps classifying the key efficiency indicators and establishing interrelation between strategic and operational performance level. The article describes the elements of accounting, in particular methods of assignment to production use of inventory, from the point of their impact on key economic indicators and, consequently, on the overall strategy of the construction enterprise.
NANOTECHNOLOGIES IN MATERIALS AND COMPONENTS SCIENCE
Authors: Korolev Evgeniy Valer’evich
Published: October 2019

The article presents the analysis of modern approach to realization of fundamentals of nanotechnology in materials and components science. The critical analysis of scope for nanotechnology was given. The paper gives definition of the term ‘nanotechnology’ considering the achieved outcomes. Relationship for assessment of technical-and-economic efficiency of new technological concepts was proposed including those achieved with the use of nanotechnology approach. Assessment of the impact of main factors effecting heterogeneous nucleation was researched, thus it was shown that indicated factors form three mechanisms of impact of original nanomaterials on structure formation of material. The presented data could be used not only for development of technological concepts, in particular based on application of original nanomaterials and providing improvement of quality of material, but also for analysis of empirical dependence, finding new effects and knowledge, and conformities for advancing traditional and innovative technologies.
MODEL AND MECHANISM OF CARBON NANOTUBE STABILIZATION WITH PLASTICIZER BASED ON POLYCARBOXYLATE
Authors: Samchenko Svetlana Vasilevna , Zemskova Olga Viktorovna , Kozlova Irina Vasilevna
Published: October 2019

The method for adding into the cement matrix composition the carbon nanotubes (CNTs) in the form of stabilized suspensions for their even allocation in its volume is observed in this article. The aim of the article is to study the aggregative and sedimentary stability of the CNTs suspensions in the presence of the plasticizer based on polycarboxylate under the ultrasonic effect, to determine the kinetic addictions of coagulation, to describe the suspension stabilization models and mechanisms according to the modern theory and to determine the possibility of using CNTs as suspensions for portland cement modification. The object of research is Portland cement, CNts and polycarboxylate-based plasticizer. Mechanism of stabilization of the CNT water suspension with polycarboxylate based plasticizer due to fixing plasticizer functional groups on the nanoparticle surface is proposed. The non-polar part of the plasticizer provides the formation of high-viscosity streak between the CNTs particles and the dispersion medium, and the polar part provides the formation of the double electrical layer (DEL), which supports the formation of the CNT micelle. The Model of the CNT micelle is described. It is established that the ultrasonic dispersion provides the stability of the CNTs suspensions for seven days and more. It is shown that when the stabilized polycarboxylate-based plasticizers of the CNT are introduced in the form of suspensions into the cement paste composition, they are evenly distributed in the volume of the cement system. This causes the production of cement stone with enhanced exploitative properties.
INTERRELATION OF SOCIAL TYPES OF ACTIVITY AND PERFORMANCE IN SPACE-PLANNING STRUCTURES OF URBAN AREAS (as exemplified in town of Irkutsk)
Authors: Anufriev Alexey Alexandrovich
Published: October 2019

In the present paper the authors researched interrelation of nine major socially critical components of activity/performance of town population which form so-called activity frames in the structure of urban areas. The methodology of layering mapping, social activity/performance of population, received by use of software applications Dubl GIS Irkutsk 2016 and Google Earth, was applied. The research is based on author’s methodology of forming human activity/performance frames. Frames are presented essentially as formations consisting of nine socially critical components of human vital activity, namely: healthcare, education, culture, sport, child welfare institutions, leisure, commerce, beauty and wellness, residential housing. On the base of implemented research the authors have found interrelation of nine socially critical types of activity which characterized by parametric properties, such as consolidation, complexity, sparseness, ‘diffusiveness’ in space-planning urban environment. The received results allow to give more qualitative assessment in the process of design, construction and renovation of urban areas, districts, neighborhood units and clusters and also to keep track of dynamics of change in human activity in urban structures.
SHOTCRETE IN MINE CONSTRUCTION
Authors: Alekseev Vyacheslav Aleksandrovich , Kharchenko Aleksey Igorevich , Solovyev Vadim Gennad’evich , Nikonorov Roman Nikolaevich
Published: October 2019

This article deals with concerns of construction of subsurface structures with the use of shotcrete as a support, the samples of mine construction with application of shotcrete have been shown, in particular projected mine with vertical well bore. The calculation method for construction of well bore with the use of shotcrete support has been stated, the major analytical relationships have been set out, a graph showing the growth of strength in a support has been generated for several sites according to the results of actual geotechnical survey. The research of properties of concrete with fast development of strength has been implemented for mine engineering and construction of transportation infrastructure. The results of experimental analysis of shotcrete with organo-mineral and chemical additives have been listed. Performance improvement of physical and mechanical properties of shotcrete has been proven when the complex active nano agent added into composition of the binder. Improved kinetics of development of strength related to accelerated admixture helps in proportioning concrete compositions for practically any firm and medium-firm grounds during construction of support of subsurface structures.
Aportaciones de la Psicología a la comunicación en el ámbito sanitario
Authors: Paz Quevedo Aguado María , Benavente Cuesta María
Published: October 2019

Este trabajo tiene como objetivo central, analizar el contexto de la comunicación interpersonal en la relación profesional sanitario-enfermo desde el ámbito de la Intervención Psicológica. Parece imprescindible incorporar a las áreas clínicas-asistenciales la formación necesaria en Técnicas y Protocolos sobre cómo informar y comunicarse con los pacientes en situaciones clínicas cotidianas, y en particular en la transmisión de malas noticias en temas generales de salud, y, específicamente en Servicios hospitalarios como los de Urgencias y Oncología. La formación en técnicas de Counselinges vital para estos profesionales que deberán paliar y potenciar las reacciones psicológicas e interpersonales que se suceden en la relación sanitario-enfermo, de ahí que se haga imprescindible la formación en los contextos universitarios para que los futuros profesionales tenga la capacidad de potenciar habilidades comunicativas que produzcan mayor bienestar personal y social, incrementando el grado de eficacia y eficiencia del Sistema Sanitario.
Trastorno por estrés postraumático en niños españoles maltratados
Authors: Castro Sáez Maravillas , Martínez Pérez Antonia , López-Soler Concepción , López-García Juan José , Alcántara-López Mavi
Published: October 2019

Objetivo: Estimar la prevalencia de Trastorno por Estrés Postraumático (TEPT) acorde a los criterios DSM-IV-TR en niños españoles expuestos a abuso crónico, y establecer las diferencias en TEPT entre niños tutelados y expuestos a violencia de pareja contra la mujer. Método: 211 menores (8-17 años) (Grupo abusado; EG=102, Grupo control; CG=109). Resultados: La prevalencia de TEPT fue 1.8% en grupo control y 16.7% en niños abusados. La prevalencia de TEPT es significativamente más alta en EG que en CG. Entre los niños no hubo diferencias significativas entre EG y CG, y en las niñas fue significativamente más alta en EG que en CG. Conclusión: los niños expuestos a violencia de pareja tienen la misma prevalencia de TEPT que los niños víctimas directas de abuso y es mucho mayor que la encontrada en población general. Es necesaria una mayor coordinación entre los servicios judicial, social y sanitario para proteger la infancia.
Libros de Texto de la historia de Brasil: Entre sujetos, prácticas y métodos (Rio de Janeiro, 1870-1920)
Authors: Lima da Silva Alexandra
Published: October 2019

Este estudio intenta comprender qué cambió y qué se mantuvo igual en la producción de libros de texto de historia brasileña durante el crecimiento de la cultura alfabetizada y el público alfabetizado en la ciudad de Río de Janeiro, de 1870 a 1920, a través de libros de texto de historia brasileña. Intenta seguir las acciones de los involucrados en este proceso (autores, libreros, editores y maestros) en busca de sus motivaciones y de los diversos significados involucrados en las experiencias de vulgarización del conocimiento histórico a través de manuales de enseñanza. La expansión de la enseñanza debe entenderse como parte de las discusiones sobre las ideas de ciudadanía y deber cívico en Brasil, particularmente en la relación entre educación y formación ciudadana, defendida por muchos, donde los sujetos lucharon a través de varias estrategias.
“La Educación Ambiental”, un desafio en la construcción del currículo pertinente para los territorios en Posacuerdo
Authors: Castro Juan Jose , Gómez Hernández Mercy Yomaira
Published: October 2019

Los habitantes de los territorios afectados por la violencia en Colombia, han vivido el drama de la desaparición de familiares, la pérdida de vecinos, el maltrato, las violaciones, la perdida de sus tierras, deterioro del medio ambiente y el desplazamiento. Factores que desestabilizaron y marcaron la vida de quienes la padecieron y que luego del proceso de paz logran vivir con un poco de más tranquilidad, requiriendo de una educación pertinente que contribuya a dar repuesta a sus necesidades.

Dentro de la investigación denominada “Pertinencia de la Educación Ambiental en el Posacuerdo”,   adelantada por los autores,  arroja como resultados la poca pertinencia  de los procesos curriculares en los establecimientos educativos, siendo  escasa   la generación de alternativas apropiadas  para la articulación de  la Educación Ambiental, requiriendo la vinculación de la comunidad educativa en la construcción del Proyecto Ambiental Escolar, empleando como ejes del aprendizaje y de  práctica pedagógica  la mitigación de los impactos ambientales provocados por el conflicto armado.
MULTIPARAMETRIC MRI IN PATIENTS WITH LOCALIZED PROSTATE CANCER AFTER RADICAL EXTERNAL RADIOTHERAPY
Authors: Krupina M. V. , Trofimova T. N. , Valkov M. Y.
Published: October 2019

Prostate cancer (PC) is the one of the most common and socially significant malignancies in men. Radiotherapy is currently one of the leading conservative special treatments for a localized and locally advanced PC. The frequency of biochemical recurrence after external beam radiotherapy (EBRT) is high. One of the main problems is a differentiation between local and systemic relapse of PC. Nevertheless, a local recurrence of PC after radiotherapy can occur without increasing PSA. Magnetic resonance imaging (MRI) is a highly informative imaging method, however, currently it is used mostly for the primary diagnosis and is not included into the recommendations for detecting recurrent prostate cancer after treatment. MR-pattern of the local progression after radical EBRT can be similar to that of primary PC. It is also difficult to diagnose local relapse of prostate cancer in some cases. Multiparametric MRI (mpMRI) has the greatest prospects in the diagnosis of local tumor recurrence in prostate cancer patients after radical external beam radiotherapy. The article provides an overview of domestic and foreign literature, in which we attempted to systematize current knowledge about the possibilities of the mpMRI in diagnosing local recurrence after radical EBRT and, based on the results of published studies, identify directions for further application of this approach.
MODERN APPROACHES TO EARLY RADIOLOGICAL DIAGNOSIS OF BONE AND CEREBRAL METASTASES OF PERIPHERAL NON-SMALL CELL LUNG CANCER
Authors: Laryukov A. V. , Laryukova E. K. , Mikhailov M. K.
Published: October 2019

Objective:сonstructive principles development of early diagnosis of bone and cerebral metastases of peripheral non-small cell lung cancer (PNSCLC), is based on the targeted preventive and personalized application of radiological and nuclear diagnostic methods.

Materials and methods.There was performed the retrospective analysis of medical cards of 1473 patients with peripheral non-small cell lung cancer for the evaluation of the characteristics and frequency of bones and brain metastases. The frequency and features of bone and brain metastases depending on clinical and morphological features of the primary lung tumor were studied. 118 patients with PNSCLC with bone and brain metastases, regardless of clinical symptoms, were examined using a wide range of modern radiological and nuclear methods.

Conclusion:the original algorithm has been developed on the study of the diagnostic significance of medical imaging methods. The application of this algorithm will significantly improve the early diagnosis of bone and cerebral metastases and improve the staging of PNSCLC.
ASPECTS OF EMPIRICAL UNDERSTANDING OF APHORISM
Authors: Ivanov Eugeney E.
Published: October 2019

Nowadays, modern linguistics pays much attention to the study of aphorism as a phrase text and a fixed phrase. In this regard, the analysis of the properties of aphorism, which characterize it in various types of discourse and spheres of communication, is particularly relevant. The article attempts to differentiate and describe various empirical understandings of aphorism. The purpose of the study is to establish and describe aspects and distinctive features of the empirical understanding of aphorism as a verbal means of expressing general judgments and universal generalization of reality in the form of phrase (phrase text). Research methods - heuristic, descriptive, taxonomic, generalization, analysis and synthesis. The material for the study are more than 100,000 aphoristic units taken from more than 300 handwritten and printed sources in Russian, Latin, English, German, French, Spanish and other languages. As a result, the notion of empirical qualification of aphorism is defined, it is a verbal means within this type of discourse or sphere of communication used in a particular social or cultural practice, the branch of knowledge (including scientific). Each particular empirical understanding of aphorism can be considered as one of the aspects of its general empirical understanding. Aspects of an empirical understanding of aphorism were formed at different times, emerged and developed in various national (or international) traditions, under the influence of various cultural trends and social processes, within the paradigms of scientific knowledge and linguocultures. It was established that there are only nine of the most significant empirical understandings of aphorism (scientific-philosophical, literary-philosophical, religious-literary, literary-fictional, literary-publicistic, literary-legal, folk-poetic, poetic-rhetorical, colloquial-linguistic understandings). Each of them forms a separate aspect of the empirical understanding of an aphorism based on a set of properties and functions (distinctive features), specific to the implementation of aphorism as a verbal means within a given social or cultural practice, the branch of knowledge. Introduction to the science the concept of “empirical understanding of aphorism” and the differentiation of aspects of such understanding is based on the use of aphorism in various types of discourse and spheres of speech communication, will allow to systematize aphoristic units as speech genres (scientific aphorisms, philosophical, literary, journalistic, legal, folklore, etc.), and also to distinguish the scientific directions of studying aphorism.
FOSSILIZATION, COMMUNICATIVE RATIONALITY AND COMMUNICATION STRATEGIES IN SECOND LANGUAGE LEARNING
Authors: Vavilova Zhanna Evgenievna , Broadbent John Taylor
Published: October 2019

Fossilization was first defined in 1972 as a failure, or an ultimate attainment in adult second language acquisition that falls short of native-speaker competence. It represents a final stage in the interlanguage development of the individual learner and characterizes all but a very few adult second language learners. Over the 40 years or so since the term appeared, fossilization in adult second language acquisition has come to be widely accepted by scholars as a genuinely existing phenomenon. Fossilization is now viewed as permanent and resistant to correction either through instruction or acculturation. However, no universally accepted definition or explanation of fossilization has achieved universal acceptance. This paper attempts to add an extralinguistic perspective on fossilization and its possible outcome in the communicative practice of adult L2 speakers by building a bridge between linguistics and teaching languages, on the one hand, and philosophy of communication, on the other. Habermasian concept of communicative rationality is applied to demonstrate that oratory and writing skills ensure a more significant role in a dialogue, which seems to be sufficient grounds for fighting fossilization. In terms of the theory of speech acts, the paper attempts to trace the mechanism of fossilizing in a transition from the inner space of an individual consciousness and intent (illocution) to the outer space of the perlocutionary consequence when a locutionary distortion of the speech itself does not affect the speaker’s intent and he / she receives no feedback of the error made. Several factors inhibiting the effectiveness of such corrective feedback are touched upon, as well as certain strategies adopted by second language learners in their communicative efforts.
Teknik Serangga Mandul Nyamuk Culex quinquefasciatus sebagai Upaya Pengendalian Vektor Filariasis di Kota Pekalongan
Authors: Sunaryo Sunaryo , Lestari Eva , Ramadhani Tri
Published: October 2019

Filariasis is a disease caused by infection filarial worms and transmitted by the bite of female mosquitoes. Controls of filariasis are still limited to the treatment of patients and prevent secondary infection, whereas the control of mosquitoes is not optimal yet. Sterile insect technique is a vector control method that environmentally friendly, effective, and potential. The study design is quasi-experimental design with pre-posttest control group design. The location of the research is in the Village of Padukuhan Kraton, District of North Pekalongan, Pekalongan City. Sterile insect technique can be made by irradiation of the male mosquitoes in the laboratory (BATAN) with dose (0 Gy, 60 Gy, 65 Gy, 70 Gy, 75 Gy and 80 Gy). The male mosquitoes exposed to irradiation testing sterility, survival, matting competitiveness and flight distance test. The male mosquitoes of Culex quinquefasciatus are derived from laboratory of Balai Litbang P2B2 Banjarnegara. Post-irradiation dose of 60 Gy, 65 Gy, 70 Gy, 75 Gy and 80 Gy obtained high sterility figures between 95.35%-98.53%, which means a chance to breed only 1.5-4.5%. The age of mosquitoes’ post-irradiation without matting about 35 days, the matting competitiveness with laboratory scale is almost close to normal (0.7-0.8), the matting competitiveness with field spring scale is lower than normal mosquito (0.04-0.2), mosquito flight range was only caught in the radius 100 m. The utilization of gamma irradiation to sterilizing Culex quinquefasciatus is effective at dose 70 Gy and can be done to intervention control of Culex quinquefasciatus in limited scope
Efectividad de las vitaminas C y E como tratamiento adyuvante a la terapia triple estándar para Helicobacter pylori en una cohorte de la Amazonía Peruana
Authors: Cubas Llalle Wildor Samir , Reyes Cahuila Rómulo , Arévalo Ramírez Heriberto , Quispe Antonio M
Published: October 2019

Introducción y objetivos: la terapia con vitaminas C y E ha sido propuesta como adyuvante a la terapia triple estándar (TTE) con el fin de incrementar la tasa de erradicación del Helicobacter pylori (H. pylori). En este estudio probamos esta hipótesis en una cohorte de pacientes de la Amazonía peruana.

Materiales y métodos: retrospectivamente, evaluamos una cohorte de 50 pacientes infectados con H. pylori del Hospital de Tarapoto en el período comprendido entre julio-diciembre de 2016; de estos, 25 fueron tratados con TTE (amoxicilina 1 g, claritromicina 500 mg y omeprazol 20 mg, dos veces al día por 14 días) en adyuvancia con las vitaminas C y E, y 25 fueron tomados al azar (1:1), quienes solo recibieron TTE. Se estimó y comparó la efectividad de ambos tratamientos utilizando un modelo regresión general lineal con familia Poisson y link log, teniendo como desenlace de interés la erradicación del H. pylori confirmada por histopatología.

Resultados: al comparar la cohorte de expuestos y con los no expuestos, no se encontraron diferencias significativas en sus características basales, incluyendo edad (38 ± 11 frente a 36 ± 10 años), género masculino (65 % frente a 63 %), síntomas y diagnóstico histopatológico. Al comparar la efectividad de ambos tratamientos, se encontró un incrementó no significativo en las tasas de erradicación del 9,5 % (91 % frente a 82 %, razón de tasas de incidencia = 1,11; intervalo de confianza [IC] 95 %: 0,92 a 1,36).

Conclusiones: la terapia adyuvante con vitaminas C y E podría ayudar a incrementar la efectividad de la TTE para H. pylori en pacientes de la Amazonía peruana, aunque se requiere confirmar esta hipótesis en un ensayo clínico.
Eğitim Sosyolojisi Açısından İlhan Başgözün Kuramsal Yaklaşımı
Authors: Devrim Topses Mehmet
Published: October 2019

Eğitim kurumu toplumsal yapının bir parçasıdır. Bu nedenle onun ekonomi ve siyaset kurumlarıyla birlikte incelenmesi gerekir. İlhan Başgöz’ün Türkiye’de Cumhuriyet dönemi eğitim uygulamalarına yönelik incelemeleri, eğitim sosyolojisi açısından özellikle iki noktadan önem taşımaktadır. Birinci olarak Başgöz, Cumhuriyet dönemi eğitim sistemini ekonomik ve siyasal temelleriyle etkileşim içinde ele almıştır. Üstelik çok derin olmasa bile, Köy Enstitülerine karşı çıkan toplumsal kesimlerin sınıfsal tabanına yönelik bazı değerlendirmelerde bulunduğu bile görülebilir. İkinci olarak ise Başgöz, tek parti dönemi eğitim uygulamalarına yakından tanıklık etmiş, bu dönemi yaşamış bir bilim insanıdır. Çocukluğu ve ilk gençliği bu dönemlere denk gelmektedir. Günümüzde eğitim kurumunun tarihsel geçmişine yönelik araştırmalarda en büyük sorun veri toplamak, sıklıkla başvurulan yöntem ise literatür ve arşivlere başvurmaktır. Bu yöntem geçerli ve kabul edilebilir olsa da veriye ulaşma yolunda bazı sınırlılıklar barındırmaktadır. İlgili tarihsel sürecin, bu dönemin içinden gelen bir bilim insanınca ele alınmış olması ise eğitim sosyolojisi için eşsiz bir veri kaynağı olarak kabul edilmelidir.

Bu makalede Başgöz’ün Cumhuriyet dönemi eğitim uygulamalarına dönük gözlemlerinden yola çıkarak ulaştığı iki temel kuramsal yaklaşıma yer verilecektir. Bu kuramsal yaklaşımlar Başgöz tarafından oluşturulup tasniflenmiş değildir. Araştırmacı tarafından makalenin konusu olarak seçilip, kuramsal dayanaklarıyla birlikte ortaya konulmuştur. Söz konusu başlıklar şöyle belirtilebilir: Birinci olarak Başgöz, toplumsal sorunların çözümünde eğitimin tek başına belirleyici bir gücü olabileceği yaklaşımını kabul etmemiştir. Eğitimin siyaset ve ekonomik koşulların etkisi altında biçimlenip yeni işlevler kazanacağı yaklaşımının altını çizmiştir. Örneğin egemen toplumsal sınıfların çıkarlarına ters düşen ya da onların desteklemediği bir eğitim uygulaması, toplumsal yapıyı ilerici yönde değiştiremeyecektir. İkinci olarak ise Başgöz, eğitim kurumunun toplumsal gerçeklere uygun ve toplumsal ihtiyaçları karşılayacak biçimde örgütlenmiş olmasının önemini belirtmiştir. Örneğin köyün ve alt toplumsal sınıfların benimseyebileceği tek eğitim uygulaması, onların ihtiyaçlarıyla bütünleşmiş bir eğitim düzenidir. Bu görüşleriyle 1930’lu yıllarda Amerika’da ortaya çıkan eğitimde yeniden yapılandırmacı görüşlerden ayrılarak Marksist kuramcılara yaklaşır. Makalede söz konusu kuramsal yaklaşımların daha ayrıntılı bir tasnifine ve açıklamasına yer verilmiştir. Tümüyle literatür taramasına dayalı betimsel bir yöntem kullanılmıştır.
Sözlü Türk Kültürünün Yaşaması ve Aktarımında Hataylı Ozanların Rolü
Authors: Yakıcı Ali
Published: October 2019

Ünlü Türk romancısı Cengiz Dağcı, bir yazısında “anayurt dediğin dildir aslında…” biçiminde bir ifadede bulunur. Ünlü yazarın belirttiği gibi coğrafyaların vatan haline dönüşmesinde dilin etkisinin önemli olduğu görülmektedir. Dilin canlı olarak yaşadığı/ yaşatıldığı kurumlardan bir de halk ozanlığı/ âşıklık geleneğidir. Yüzlerce yıl bulunduğu coğrafyada yaşayan insanların dili, gönlü ve yükselen sesi olan ozanlar Türkçeyle doğumdan ölüme kadarki süre içinde bulunduğu insanının yaşadıklarını şiirleştirmiş, böylece tarihe tanıklık ederken sözlü kültürle birlikte eserlerini oluşturduğu Türkçenin de yaşamasına ve gelecek kuşaklara aktarılmasına büyük ölçüde yardımcı olmuştur. Bu bakımdan bu bildiriyle Hataylı ozanların yaşadıkları dönemde bulundukları bölgeye tanıklık edecek eserler oluştururken bunlarla Türk kültürel kimliğinin yaşatılması ve geleceğe aktarılmasında oynadıkları rolün fark edilmesi amaçlanmaktadır.
Bu çalışmayla, Hatay’da Türk kültür varlığının yaşaması ve Hatay’ın ebedi bir Türk vatanı olarak devamında etkili olan ve gün ışına çıkmamış sözlü kültür ürünleri ela alınıp işlenecektir. Bunlar içinde başta Kırıkhan ilçesi ve özellikle Ceylanlı Köyü ozanları olmak üzere Sefil Molla, Sefil Hasan, Sefil Ahmet gibi kimileri Halep’te ikamet etmiş oradan Hatay’a gelmiş olan âşıkların yazmalarda yer alan şiirlerinin Hatay’da bir kültür hazinesinin oluşumundaki rolü ve tesiri tartışılacaktır.