bluuebunny/crossref_metadata_2025 huggingface dataset:
SemConvTree: Semantic Convolutional Quadtrees for Multi-scale Event Detection in Smart City
Authors: Kovalchuk Mikhail Andeevich , Filatova Anastasiia , Korneev Aleksei , Koreneva Mariia , Voskresenskii Aleksandr , Nasonov Denis , Boukhanovsky Alexander
Published: July 2024

The digital world is increasingly invading our reality, which leads to the formation of a significant reflection of the processes and activities taking place in the smart city. Such activities include well-known urban events, celebrations, and those with a very local character. Due to the mass occurrence, events have a comparable influence on the formation of the spirit and the urban atmosphere. This work presents an enhanced semantic version of the ConvTree algorithm - SemConvTree. It allows considering the semantic component of the data obtained by using semi-supervised learning of topic modeling ensemble (consisting of improved models BERTopic, TSB-ARTM, SBert-Zero-Shot). We also present an improved event search algorithm based on both statistical evaluations and semantic analysis of posts. This algorithm allows fine-tuning the mechanism of discovering the required entities with the specified particularity (such as a particular topic). Experimental studies were conducted within the area of New York City. They showed an improvement in the detection of posts devoted to events (about 40% higher f1-score) due to the accurate handling of events of different scales. These results lead in the long term to talk about the potential perspective in creating a semantic platform for the analysis and monitoring of urban events in the future.
A GIS-Based Framework to Analyze the Behavior of Urban Greenery During Heatwaves Using Satellite Raster Data.
Authors: Cardone Barbara , Di Martino Ferdinando , Miraglia Vittorio , Mauriello Crisiano
Published: July 2024

In this work is proposed a new unsupervised method to evaluate the behavior of urban green areas in presence of heatwave scenarios analyzing the NDVI, NDMI and LST satellite data. To evaluate how these three indices characterize urban green areas during periods of heat waves, a reclassification of the data raster of each index is carried out. Rather than using standard classifications of the three indices, an unsupervised classification approach is proposed that uses the Elbow method to determine the optimal number of classes and the Jenks thematic classification method. Each class is assigned a Gaussian fuzzy set with means and standard deviations equal to that of the associated thematic class. The green urban areas are classified using zonal statistics operators and the degree of membership in the corresponding fuzzy set is used to assess the reliability of the classification. Finally, for each type of greenery the frequencies of belonging to the NDVI, NDMI and LST classes are analyzed to evaluate the behavior of the type of urban greenery during heatwaves. The framework was tested in an urban area consisting of the city of Naples (Italy). The results show that some types of greenery, such as deciduous forests and olive groves, are not very vulnerable to heatwave scenarios, unlike uncultivated areas which, instead, show critical behaviors during heatwaves.
Assesses of Chronic Lymphocytic Leukemia Cases with Isoform p53 Protein using Elisa Method
Authors: Gheorghe Ioan-Ovidiu , Udristioiu Aurelian , Banta Andreea-Mihaela Banta Banta
Published: July 2024

Background P53 gene mutation is a very common event in human neoplasia, and genetic mutations in the P53 gene in a single allele are responsible for a hereditary cancer susceptibility syndrome (Li Fraumeni). These variants encode distinct isoforms of the p53 protein, which may disrupt its transcriptional activity. These point mutant proteins are more stable than the normal protein and the mutant product accumulates at a high level that allows obtaining important information about p53 gene expression in malignant cells, especially in Chronic Lymphocytic Leukemia, (CLL). By Enzyme Linked Immune-Absorbent Assay method, (ELISA), was analyzed the frequency of p53 protein expression to 20 eligible patients diagnosed with CLL for to investigate the relationship of this protein in the stages of the disease and the impact on treatment response and survival. In ELISA technique was used the specific antibodies for isoform p53 protein, PAb 240 antibodies. These antibodies bind specifically to denatured p-53 protein. Species reactivity is for human in conformity with the prospect from Manual, Catalog No. LS-F174, Bio-Rad. Results The average concentrations of p53 proteins in 17 of 20 cases were found 16.76 μg / dl, with CV = 0.5% and the probability index p = 0.034. Very high pathological values in the 3 cases of isoform p53 protein were calculated in 2 men, (PM) in the value of 60 µg / dL, respectively at 40 µg / dL and in the case of females, (PW), in 40 µg / dL value, with the transformation into Diffuse Large Lymphoma, (DLL). Conclusion This ELISA method has proven to be a useful prognostic tool for the application of personalized treatment of on-immune therapy, in cases diagnosed with the type B-CLL.
From the “One Molecule – One Target – One Disease” Concept towards Looking for Multi-target Therapeutics for Treating Non-polio Enterovirus (Npev) Infections
Authors: Roux Hugo , Touret Franck , Rathelot Pascal , Vanelle Patrice , Roche Manon
Published: July 2024

Non-polio enteroviruses (NPEVs), namely coxsackieviruses (CV), echoviruses (E), enteroviruses (EV), and rhinoviruses (RV), are responsible for a wide variety of illnesses. Some infections can progress to life-threatening complications in children or immunocompromised patients. To date, no treatments have been approved. Several molecules have been evaluated through clinical trials without success. To overcome these failures, the multi-target directed ligand (MTDL) strategy can be applied to tackle enterovirus infections. This work analyzes clinical trials to highlight the best candidates and develops filters to apply to a selection for MTDL synthesis. We explicitly stated the methods used to answer the question: Which solution can fight NPEVs effectively? We note the originality and relevance of this proposal in relation to the state of the art in the enterovirus-inhibitors field. Several combinations are possible to broaden the antiviral spectrum and potency. We discuss data related to the virus and data related to each LEAD compound identified. Overall, this study proposes a perspective on different strategies to overcome issues identified in clinical trials and evaluate the “MTDL” potential to improve the efficiency of drugs synergistically, broaden the targeted, and reduce the adverse effects and drug design cost as well as limit the opportunity of drug-resistant viruses.
Regulation of LaeA and Velvet Proteins on the Production of Mycotoxins and Other Fungal Secondary Metabolites
Authors: Hou Xuwen , Liu Liyao , Xu Dan , Lai Daowan , Zhou Ligang
Published: July 2024

Fungi are rich sources of secondary metabolites of agrochemical, pharmaceutical and food importances, such as mycotoxins, antibiotics and antitumor agents. Secondary metabolites play vital roles in fungal pathogenesis, growth and development, oxidative status modulation, and adaptation/resistance to various environmental stresses. LaeA contains an S-adenosylmethionine binding site and displays methyltransferase activity. The members of velvet proteins include VeA, VelB, VelC, VelD and VosA, for each member with a velvet domain. LaeA and velvet proteins can form multimeric complexes such as VosA-VelB and VelB-VeA-LaeA. They belong to global regulators and are mainly impacted by light. One of their most important functions is to regulate gene expression that are responsible for secondary metabolite biosynthesis. The aim of this mini-review is to represent the newest cognition on the biosynthetic regulation of mycotoxins and other fungal secondary metabolites by LaeA and velvet proteins. In most cases, LaeA and velvet proteins positively regulated production of fungal secondary metabolites. The regulated fungal species mainly belong to the toxigenic fungi from the genera of Alternaria, Aspergillus, Botrytis, Fusarium, Magnaporthe, Monascus, and Penicillium for the production of mycotoxins. We can control secondary metabolite production to inhibit the production of harmful mycotoxins while promoting the production of useful metabolites by global regulation of LaeA and velvet proteins in fungi. Furthermore, the regulation by LaeA and velvet proteins should be a practical strategy in activating silent biosynthetic gene clusters (BGCs) in fungi to obtain previously undiscovered metabolites.
DiADEM - Dance Against Dementia Effect of a Six-Month Dance Intervention on Physical Fitness in Older Adults with Mild Cognitive Impairment: A Randomized, Controlled Trial
Authors: Thiel Ulrich , Stiebler Marvin , Labott Berit K. , Bappert Johanna , Langhans Corinna , Halfpaap Nicole , Grässler Bernhard , Herold Fabian , Schreiber Stefanie , Braun-Dullaeus Rüdiger , Müller Patrick , Müller Notger , Hökelmann Anita
Published: July 2024

Background: Preserving health and physical fitness is critical to ensure independent living across the lifespan. Lower levels of physical fitness are associated with age-related cognitive decline and a higher prevalence of mild cognitive impairment (MCI). Thus, this study investigates the influence of a six-month dance intervention on selected measures of physical fitness in older adults with MCI. Methods: In this randomized controlled trial 55 patients with MCI were randomized into a sportive dance training (IG; n=26; Age: 70.7 +/- 5.6 years; 62% female) or an inactive control group (CG; n=24; Age: 69.1 +/- 6.8 years; 46% female).The dance group received two 90-minute dance training sessions per week over a duration of six-months, which focused on learning dance movement patterns. During the training sessions, heartrate was measured to control exercise intensity. Physical fitness was assessed using cardiopulmonary exercise testing (CPET), lower limb functional fitness via sit-to-stand test, handgrip strength and heart rate variability (HRV). Results: We observed that the dance intervention preserved the cardiorespiratory fitness as measured by maximal oxygen uptake (VO2max) during CPET, which decreased in the CG. Furthermore, participants in the IG demonstrated increases in leg and handgrip strength although not statistically significant. HRV displayed a nonsignificant decrease following the intervention. Conclusion: The results of this randomized controlled trial suggest that sportive dance training can preserve physical fitness in older adults with MCI. Although improvements in the other parameters were statistically non-significant, likely due to the small sample size, stabilizing muscular fitness and preventing age-related decline in older adults with MCI is important for maintaining functional independence.
The Effect of Sundarbans Honey vs Energy Drinks on Exercise, Fatigue, and Antioxidant Defense via NRF2/HO-1 Pathway – An Experiment in Mice
Authors: Azim Al , Hossain Jakir , Ceylan Halil İbrahim , de Assis Gilmara Gomes , Almeida-Neto Paulo Francisco , Hanif Khalid Hasan , Biswas Kamal Krishna , Mauwa Jannatul , Khatun Mahafuja , Mithon Mehedi Hasan , Bragazzi Nicola Luigi
Published: July 2024

Excessive oxidative stress and exercise-induced fatigue reduce physical performance and can lead to dysfunction in antioxidant systems within muscular and hepatic tissues. Integrating natural substances with exercise may mitigate fatigue via anti-oxidant effects. This study aims to compare and evaluate the effects of exercise and supplementation with Sundarbans honey vs energy drinks on the strength, anxiety physiological profiles, and hepatic antioxidant capacity in mice undergoing extraneous exercise and fatigue. Forty-eight four-week-old Swiss albino mice were randomly assigned to one of eight groups: (1) Control, (2) Speed™ (Sp), (3) Royal Tiger™ (RT), (4) Sundarbans Honey (SH), (5) Exercise (Ex), (6) Exercise + Sundarbans Honey (Ex+SH), (7) Exercise + Speed™ (Ex+Sp), and (8) Exercise + Royal Tiger™ (Ex+RT). Supplements were administered via oral gavage: Sp (2.5 ml/kg BW), RT (2.5 ml/kg BW), and SH (1 g/kg BW), four times a week for 60 days. Mice in the Ex, Ex+SH, Ex+Sp, and Ex+RT groups underwent daily swimming and running. The strength, fatigue, anxiety levels, lipid profiles, and antioxidant biomarkers were evaluated post-treatment. The SH, Ex, and Ex+SH groups exhibited significantly enhanced physical performance (p
Is pericarditis a complication or manifestation of meningococcal infection caused by Neisseria meningitidis serogroup W in a child?
Authors: Markova K.V. ,   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg, Russian Federation, Skripchenko E.Yu. , Skripchenko N.V. , Vilnits A.A. , Chuprova S.N. , Rudneva E.P. , Gornov S.V. ,   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg, Russian Federation,   Saint-Petersburg Pediatric Medical University, Saint Petersburg, Russian Federation,   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg, Russian Federation,   Saint-Petersburg Pediatric Medical University, Saint Petersburg, Russian Federation,   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg, Russian Federation,   Saint-Petersburg Pediatric Medical University, Saint Petersburg, Russian Federation,   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg, Russian Federation,   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg, Russian Federation,   Medical Institute of Continuing Education, Moscow State University of Food Production, Moscow, Russian Federation
Published: July 2024

Meningococcal infection is one of the most insidious and dangerous infections (due to the risk of lethal outcome up to 80% when septic shock develops). The article presents a clinical observation of patient A. 4 years old, who had a generalized form of meningococcal infection (GFMI) caused by meningococcus of serogroup W. Despite targeted adequate etiopathogenetic therapy, heart damage developed, which was diagnosed late in the course of the disease (day 26 of the disease). The world literature describes cases of development of complications of GFMI in children caused by N. meningitidis serogroup W at late stages of the disease in the presence of targeted therapy and with CSF sanitation. All of the above necessitates a complex clinical and neurophysiological examination in the periods of early and late recuperation and an individual program of medical rehabilitation. It should be emphasized that if there is a suspicion of complications in the late recovery period, the prescription of complex pathogenetic therapy, including the use of non-steroidal anti-inflammatory drugs and drugs with antioxidant, antihypoxic and cytoprotective effect, such as cytoflavin, is shown to improve the outcome of the disease. Key words: meningococcal infection, children, N. meningitidis serogroup W, meningitis, pericarditis, cytoflavin, medical rehabilitation
Contemporary Bergsonism and Philosophy of Cosmology
Authors: Auman Anastasia ,   National Research University Higher School of Economics, School of Philosophy and Cultural Studies
Published: July 2024

The article examines the figure of Henri Bergson as a philosopher of science and the relevance of his ideas for modern philosophy of cosmology. In the first part, Bergson’s philosophy is analyzed based on the classification of philosophical ap­proaches to science presented by G. Gutting. It is problematic to classify Berg­son’s philosophy of science in this system due to the fact that he combines fea­tures of empirical and ontological approaches. It is concluded that it is difficult to uncover a systematic philosophy of science in Bergson’s works because they are structured around the notion of duration, rather than around scientific enquiry. The second part describes and analyzes the cosmological motifs in Bergson’s works, the questions of human interaction with the world, preservation of the past in memories, the ontology of duration. In conclusion, three promising areas of Bergsonian research in contemporary philosophy of cosmology are high­lighted: cosmology as a physical discipline, the study of the Universe in the past and in its evolution, and the philosophical problems of many-world models in cosmology.
Losev Alexei Fedorovich
Authors: Popov Yuri ,   RAS Institute of Philosophy
Published: July 2024

Alexei Losev (10[22].09.1893, Novocherkassk – 24.05.1988, Moscow), Russian philosopher, philologist and writer, is the creator of a unique religious-philosophical system, which combines the reinterpreted tradition of ancient and medieval thought (Plato and Neoplatonism, Christian apophatic theology of Dionysius the Areopagite, Gregory Palamas, Nicholas of Cusa), the methodology of New European philosophy (German classical idealism, neo-Kantianism, phenomenology of E.Husserl) and the problems of New European philosophy (German classical ideal-ism, neo-Kantianism, phenomenology of E.Husserl) and the problems of Russian religious philosophy of the late 19th and early 20th centuries, from V.S. Solovyov (the idea of universalism) to P.A. Florensky. In the constructive design of Losev’s system the central place is occupied by dialectics, in the multidimensional construction of which each category and all of them together are worked out in the light of each other. Losev’s personalistic ontology is the basis of his philosophy of language (naming as an interpretative - communicative self-discovery of personality), philosophy of myth as a distinctive form of personal worldview (myth as directly experienced and created reality, symboli-cally expressed), and aesthetics (artistic form is “personality as symbol and symbol aspersonality”). Losev was the founder of the philosophy of music in Russia. His multi-volume history of ancient aesthetics represents the history of the entire ancient culture revealed in its symbolic-expressive aspects. The works of Losev, are presentative of the last generation of the Silver Age of Russian culture, became a kind of completion of Ortho-dox religious philosophy in Russia in the 19th and early 20th centuries.
Psychoanalysis and christianity. The oretical dynamics
Authors: Osipova Tatyana
Published: July 2024

The subject of this research is the psychoanalytic theory of religion and the evolution of its interpretation of Christianity. The dynamics of theoretical development is represented by three main epochs of development. First, it is worth considering the prerequisites from which psychoanalysis and the psychoanalytic theory of religion originated. In Western Christian culture, the intellectual thought of the XIX–XX centuries is fueled by the Enlightenment era, the philosophy of the “death of God” and scientific progress. But psychoanalysis is initially in a twofold position: it exposes primitive ideas about religion, and at the same time there is a lot of evidence that the symbolism and revelations of intuition embedded in the Judeo-Christian religion are included in its structure. The next milestone is the reign of existentialism and the development of postmodern thought. The understanding of the spiritual aspects of the human subject is significantly deepened. Psychoanalytic thinking about religion perceives existential intuitions and turns out to be an ally of Christianity. Finally, the third stage, when by the beginning of the XXI century there is a characteristic request of the New Time for the transformation of previous knowledge about religion and religiosity, from the side of psychoanalysis there are a number of important discoveries about the subject. The dialogue of religions and psychoanalysis is becoming extremely relevant and, as this study shows, modern psychoanalysis has worthy answers to the problem of Christianity in the post-Christian (secular) world. The research is based on the theory of religion, in addition to the theory of Freud, by such authors as G. Bataille, J.Lacan, Y.Kristeva, as well as modern psychoanalytic developments in the field of studying the reality of a religious subject, presented on the intellectual scene over the past decades. In conclusion, conclusions are given regarding the general discourse of psychoanalysis and Christianity.
Processo dialógico de ensino e aprendizagem intergeracional
Authors: Araujo Moura Cleiton , Nicolas Silva Alves André , Rodrigues dos Santos Eunice , Celestin Roberd , Graziele Brandt Andressa
Published: July 2024

Este artigo relata a experiência acerca do curso de extensão denominado Inicialização tecnológica para pessoas idosas, que foi possibilitado e disponibilizado pelo Edital nº 17/2022 - GAB/CAMB, com vagas para diversos cursos voltados para pessoas idosas e o único curso relacionado à informática ofertado pelos bolsistas do Programa de Educação Tutoria (PET) Conexão de Saberes: Educação, Trabalho, Meio Ambiente e Responsabilidade Social, no IFC - Campus Camboriú. O objetivo do curso foi incluir a pessoa idosa no mundo da tecnologia da informação. A abordagem metodológica é qualitativa e se caracteriza como relato de experiência da realização, do planejamento das aulas e das ações do curso desenvolvidas pelos PETianos com as pessoas idosas. Como resultados, destacamos que o curso teve relevância social, pois foi concluído com satisfação pelos participantes, proporcionando atividades de inclusão da pessoa idosa com o uso de tecnologias e computadores, oferecendo novas oportunidades de aprendizagem, desenvolvimento pessoal, educação acessível às pessoas idosas. Aos bolsistas do PET, foi uma oportunidade de troca de experiências, de conhecimentos entre eles e os cursistas em um processo dialógico de ensino e de aprendizagem intergeracional.
Structure in prime gaps
Authors: KAUNDA KAJANI
Published: July 2024

We define a Cayley Table T from the structure (J,+) based on a subset J of Z containing prime numbers and their additive inverses, which we then use as a model of gaps between primes of the form pα − 3. Using definitions of the relationships between primes and their gaps derived from T, we prove the existence of infinitely many pairs of primes, (pn, pn+m), such that (pn+m − pn) = (pα − 3) where n, α ≥ 3 and m ≥ 1 and pn is the nth prime. Finally, we use this result to show the existence of infinitely many pairs of prime numbers with a gap of 2.

MSC Classification: 11N05, 11B05
Multimodal Imaging of Dark Without Pressure Lesions in Pediatric Retinal Vasculitis
Authors: Nguyen Quan Dong , Yasar Cigdem , Ghoraba Hashem , Hassan Muhammad , Or Chris , Akhavanrezayat Amir , Regenold Jonathan , Park Sung Who , Khojasteh Hassan , Halim Muhammad , Karaca Irmak , Pham Brandon , Uludag Gunay , Matsumiya Wataru
Published: July 2024

Purpose: A unique form of retinopathy-plausibly dark without pressure (DWP) was identified during the management of pediatric patients with retinal vasculitis (RV) and described in the index case series.
Methods:Forty-three consecutive pediatric uveitis patients presented to tertiary care-unit were evaluated. We assessed DWP-like lesions in pediatric patients with RV. Wide angle fundus photographs (WAFP), fundus autofluorescence (FAF), and optical coherence tomography (OCT) images were analyzed to identify potential retinopathy. Incidence of DWP in pediatric RV patients was also analyzed. WAFP were evaluated using image-J software to measure retinopathy area (RA).
Results:Twenty-six of 43 patients were diagnosed with RV and were treated. Retinopathy was detected in 20 patients (30 eyes/76.9%) during treatment. Mean age was 12.8±3.36 years; 40% were female. On WAFP, the lesions appeared as dark areas that were diffuse, mid-peripheral or peripheral. All 20 patients (30 eyes) showed hypo-autofluorescence on FAF at the same locations as the WAFP. Twelve patients (17 eyes) who had OCT images of the RA demonstrated ellipsoid zone disruption. Progression of the retinopathy overtime was analyzed in 28 eyes; all eyes showed improvement of RV with therapy. Mean RA significantly decreased from 394.67 mm2 (time of retinopathy detection) to 365.88 mm2 (last follow-up) (p=0.03).
Conclusions:Pediatric RV may be associated with a retinopathy pattern described as DWP previously. Improvement in the RA may be related to improvement of disease activity, but further studies are needed to understand the underlying pathophysiology. Such findings might serve as a marker of previous/ongoing RV in pediatric patients.
Is Sexual Activity an Effective Way to Expel Distal and Intramural Ureteral Stones? An Updated Systematic Review and Meta-analysis
Authors: Neto Edgar Paulo da Silva , Morriello Rafael , Victor David Romeiro , Reis Camila Mariana de Paiva , Lech Gabriele Eckerdt , Silva Raquel Oliveira de Souza , Viana Patrícia , Melao Barbara Vieira Lima Aguiar
Published: July 2024

Purpose: Ureterolithiasis is a prevalent condition with a high morbidity, typically causing incapacitating pain and, if not treated correctly, can lead to renal failure. This research has sought to investigate the link between sexual activity, including masturbation, and a higher rate of spontaneous expulsion of ureteral stones.
Material and Methods: We searched PubMed, Embase, and Cochrane for randomized clinical trials (RCT) assessing the effectiveness of sexual activity or masturbation in the elimination of distal or intramural ureteral stones. Heterogeneity was assessed with I². Values of p < 0.05 were considered statistically significant. Statistical analysis was performed using Review Manager 5.4.1 (Cochrane Center, The Cochrane Collaboration).
Results: We included 8 RCTs, totaling 755 patients, of which 383 (50.7%) engaged in sexual activity or masturbation 3-4 times per week for an average duration of 4 weeks. The expulsion rate at 2 weeks (OR: 3.48; [95% CI: 2.37 to 5.11]; p < 0.00001) and at 4 weeks (OR: 3.28; [95% CI: 2.23 to 4.83]; p < 0.00001) was higher in the sexual activity or masturbation group. The average time for stone expulsion (MD: -3.27; [95% CI: -5.38 to -1.17]; p < 0.002) was shorter in the experimental group, as well as the average number of analgesic injections (MD: -0.6; [95% CI: -0.91 to -0.29]; p < 0.0001).
Conclusion: Our findings suggest that sexual activity or masturbation appears to be effective as an expulsive medical therapy for patients with distal or intramural ureteral stones.
Robust self-testing of Bell inequalities tilted for maximal loophole-free nonlocality
Authors: Chaturvedi Anubhav , Gigena Nicolas , Panwar Ekta , Scala Giovanni , Araujo Mateus , Farkas Mate
Published: July 2024

The degree of experimentally attainable nonlocality, as gauged by the amount of loophole-free violation of Bell inequalities, remains severely limited due to inefficient detectors. We address an experimentally motivated question: Which quantum strategies attain the maximal loophole-free nonlocality in the presence of inefficient detectors? For any Bell inequality and any specification of detection efficiencies, the optimal strategies are those that maximally violate a tilted version of the Bell inequality in ideal conditions. In the simplest scenario, we demonstrate that the quantum strategies that maximally violate the tilted versions of Clauser-Horne-Shimony-Holt inequality are unique up to local isometries. However, self-testing via the standard sum of squares decomposition method turns out to be analytically intractable since even high levels of the Navascués--Pironio--Acín hierarchy are insufficient to saturate the maximum quantum violation of these inequalities. Instead, we utilize a novel Jordan's lemma-based proof technique to obtain robust analytical self-testing
statements for the entire family of tilted-Bell inequalities. These results allow us to unveil intriguing aspects of the effect of inefficient detectors and the complexity of characterizing the set of quantum correlations, in the simplest Bell scenario.
Increasing access to psychological therapy on acute mental health wards: Staff and patient experiences of a stepped psychological intervention
Authors: Johnston Isobel , Edge Dawn , Wilson Paul , Beinaraviciute Adele , Bucci Sandra , Drake Richard , Gilworth Gill , Haddock Gillian , Handerer Fritz , Kaur Sonalia , Lovell Karina , Morley Helen , Price Owen , Samji Mica , Berry Katherine
Published: July 2024

Background
Psychological therapies are recommended for people with serious mental health problems. However, access is limited, particularly in inpatient mental health settings. The Talk, Understand and Listen in InPatient Settings (TULIPS) study is a large multi-centre cluster-randomised controlled trial which aimed to evaluate a stepped psychological intervention model to increase access to therapies for inpatients. This paper presents findings from the embedded process evaluation focusing on the contextual factors influencing intervention delivery.
Methods
Thirty-two staff and 31 patients from wards receiving the intervention participated in semi-structured interviews. Data was analysed using reflexive thematic analysis. Staff and patient data were analysed separately but perspectives were compared and interwoven resulting in five themes.
Results
Patients reported sessions with psychologists facilitated greater self-understanding and coping. Staff and patients reflected that formulations improved staff understanding of patient presentations. This understanding was associated with improved staff-patient relationships, more person focused practice and reduced conflict and burnout. Psychologists’ frequent physical presence on the wards and support of nursing teams enabled staff buy-in. However, significant barriers in resource, skill and confidence inhibited the delivery of nurse-led interventions within the stepped care model, as did perceptions that intervention delivery was outside the remit of nursing staff’s role.
Conclusions
This study provides evidence that a stepped psychological intervention on acute mental health wards could improve patient coping and ward experience for patients and staff. Future studies should target nursing staff confidence and skill in the delivery of psychological interventions.
Trial registration:
ClinicalTrials.gov Identifier: NCT03950388. Registered 15th May 2019. https://clinicaltrials.gov/ct2/show/NCT03950388
WITHDRAWN: The effects of community built environment and physical activity of varying intensity and purpose on depressive trajectories among middle-aged and elderly: a national longitudinal study based on latent growth curve modeling
Authors: Zhang Kaili , Huang Bowen , Divigalpitiya Prasanna
Published: July 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Investigating the prevalence and influential factors of ankle pain following total knee arthroplasty in patients with varus and valgus knee deformities
Authors: Huang Zishuai , Wang Jian
Published: July 2024

Background: The postoperative time-dependent changes in knee alignment and the subsequent adaptive changes in the ankle and the mechanism of postoperative foot pain after total knee arthroplasty have not been well established. The aim of this study was to assess the imaging alterations in the ankle, subtalar, and knee joints following total knee arthroplasty (TKA)for correcting varus and valgus deformities, as well as to observe the incidence of post-TKA ankle pain and analyze its influencing factors.
Method: This retrospective cohort study included 67 patients with varus and valgus knee osteoarthritis who underwent total knee arthroplasty . The patients were categorized into two groups based on the alignment of their knee joint, namely the varus group and the valgus group. Subsequently, they were further divided into a foot and ankle pain group or a foot and ankle non-pain group depending on the presence or absence of postoperative foot pain. Radiological assessments of the lower limbs, ankle joints, and hindfoot were conducted before surgery as well as at 3 months post-surgery, along with clinical evaluations of the ankle joint. Each data was compared between patients with and without foot pain.
Result: When the lower limb was aligned to the neutral position by TKA, the distal tibia and talus exhibited a more horizontally oriented alignment relative to the ground compared to the preoperative alignment. Patients with knee varus demonstrated an evaginate transition towards varus, which was accompanied by an increase in ankle ectropion. In contrast, patients with genu valgus maintained their hind foot's varus position while experiencing an increased ankle varus. Due to the limited range of motion in the ankle and subtalar joints, acute correction of the knee following total knee arthroplasty cannot be compensated for by these joints. In comparison to the painless group, individuals experiencing foot discomfort maintained a preoperative force line in the ankle and subtalar joint while also undergoing a greater degree of correction in the contrapuntal line of the knee joint.
Conclusion: About one fifth of total knee arthroplasty (TKA) patients experience postoperative foot pain. Despite obtaining an appropriate coronal alignment of the knee joint after surgery, these patients may still experience uneven foot force due to inadequate compensation of the ankle and subtalar joints. Surgeons should consider potential ankle and hindfoot compensation disorders and postoperative ankle pain when planning and performing TKA.
Hyperwide band electromagnetic wave absorbing Al2O3 coating boosted with in-situ generated nano TiO1.81
Authors: Yu wenbo , Ma Chaosheng , Ma Yihu , Ma Guozheng , Haidou Wang
Published: July 2024

No choice but to choose the dielectric loss type materials for realizing the high temperature electromagnetic (EM) wave dissipation is well acknowledged, as the magnetic EM wave absorbing materials generally have functional failure above 600°C 1. However, the electromagnetic wave absorption bandwidth (EAB) of current dielectric loss type materials is too narrow. Here, we invented one TiO1.81/Al2O3 coating characterized with the twice of the widest EAB reported among all the current dielectric loss type materials. The simple fabrication process is composed of the supersonic atmospheric plasma spraying (SAPS) of Ti2AlC/Al2O3 powders and following oxidation at 950°C for 2 h in air. The occurred in-situ double decomposition mechanism transformed Ti2AlC (45 µm) into O-vacancy-defected TiO1.81 (30 nm). The interfacial polarization contribution was suddenly boosted due to the appearance of a huge amount of nano hetero-interfaces. The continuous outwards diffusion of Ti and Al elements further endows our coating self-protective capacity through the formation of covered TiO1.81 and Al2O3. As MAX phase contains more than 90 categories, our work supports one open window for fabricating superior EM wave absorbing coatings used in high temperatures.
Explainable machine learning framework for dynamic monitoring of disease prognostic risk
Authors: Ishikawa Tetsuo , Shinoda Masahiro , Oya Megumi , Ashizaki Koichi , Ota Shinichiro , Kamachi Kenichi , Sakurada Kazuhiro , Kawakami Eiryo , Shinkai Masaharu
Published: July 2024

Patients’ conditions continue to change after the diagnosis, with each patient showing a different time course. Here, we propose a dynamic prognostic risk assessment framework based on longitudinal data during hospitalization, using coronavirus disease (COVID-19) as an example. We extracted electronic medical records of 382 COVID-19 cases treated at Tokyo Shinagawa Hospital between 27 January and 30 September 2020. Gradient boosting decision trees were used to predict the maximum clinical deterioration, including deaths, from the data at initial diagnosis. Random survival forests were then used to calculate a 7-day cumulative hazard function to dynamically assess the risk of mortality of patients on each day during hospitalization. SurvSHAP(t) was applied to provide a time-dependent explanation of the contribution of each variable to the prediction. The prediction at initial diagnosis agreed well with the actual severity (area under the receiver operating characteristic curves = 0.717–0.970), but some cases showed discrepancies between actual and predicted prognosis. The dynamic mortality risk assessment during hospitalization could discriminate between deceased and surviving patients 1–2 weeks before the outcome. Early in hospitalization, C-reactive protein (CRP) was an important risk factor for mortality, while in the middle period peripheral oxygen saturation (SpO2) increased its importance and platelets and β-D-glucan were the main risk factors immediately before death. Dynamic risk assessment considering heterogeneous risk factors and time-to-event is useful for the early detection of patients who deteriorate rapidly after hospitalization. This framework provides healthcare professionals with the explainable real-time guidance for clinical decision-making during hospitalization.
Exploring family health, Support, Self-efficacy and Quality of Life during the cancer trajectory: A protocol for a longitudinal mixed methods multi-center cohort study
Authors: Tolstrup Laerke K. , Hyldig Nana , Möller Sören , Stie Mette , Kjerholt Mette , Jarden Mary , Piil Karin , Coyne Elizabeth , Garcia-Vivar Cristina , Voltelen Barbara , Munk-Olsen Trine , Dieperink Karin B.
Published: July 2024

Introduction
A cancer diagnosis not only profoundly impacts individuals but also the very core of their families, reshaping their lives in many ways. However, there is a lack of focus on the well-being and health of the entire family across adult cancer research. This is concerning given that one-third of the Danish population will get a cancer diagnosis before the age of 75, suggesting that many Danes will become caregivers during their lifetime. In addition, identifying vulnerable families is challenging and the determinant factors for their vulnerability are unknown.
Aims
The principal aim of this study is to investigate family health during cancer treatment. This will be done by gathering information on various parameters such as perceived support, quality of life, and self-efficacy in patients with cancer and families across the cancer trajectory. Additionally, the study seeks to pinpoint particularly vulnerable families and investigate contributing factors to their vulnerability.
Methods
This mixed-methods study follows a sequential explanatory design, combining patient-reported outcomes in a longitudinal, prospective multicenter survey with interviews conducted with a nested sampling of the participants from the survey. A total of 240 patients diagnosed with prostate-, breast-, gastrointestinal-, and lymphoma cancer, and designated adult family caregivers will be recruited from six different sites for the survey. Variables such as family health, needs and perceived support, quality of life, self-efficacy, depression, stress, and resilience will be explored. Survey data will be collected at baseline, 3, 6, 12, and 18 months. The interviews (n = 12-15) will be conducted twice with patients and caregivers jointly; once during the treatment phase (3 months) and once after completion of treatment (12 months).
Discussion
This study will provide new insights into the unique needs and challenges of families navigating the complexities of cancer. Tracking their experiences longitudinally will deepen our understanding of the families' health and investigate determinant factors for vulnerability during the cancer journey. These insights can inform the development of targeted interventions and support services, ultimately improving the quality of care to vulnerable families facing cancer-related challenges.
Trial Registration:
ClinicalTrials.gov: NCT06433349
Protocol version 2.0
MRI–radiomics–clinical–based nomogram for prediction postpartum hemorrhage in patients with suspected placenta accrete spectrum before cesarean section
Authors: Hu Yumin , Huang Yechao , Chen Bo , Shen Di , Li Xia , Wang Zufei , Zhou Zhangwei , Wang Haiyong , Yan Zhihan , Lu Chenying
Published: July 2024

Purpose
To develop and validate the nomogram by combining MRI-derived radiomics and clinical features for predicting postpartum hemorrhage in high-risk placenta accreta spectrum (PAS) patients before cesarean section.
Methods
The T2WI sagittal MR images and clinical data of 70 postpartum hemorrhage (+) pregnant women and 104 postpartum hemorrhage (-) pregnant women were retrospectively collected from two centers. These pregnancies were divided into a training (n = 105), an independent validation (n = 28), and an external validation (n = 41) cohort. Radiomic features were extracted, and radiomics signature were constructed. Clinical features were analyzed retrospectively. The clinical model, the radiomic model, and the clinicoradiomic model were compared. The nomogram of the optimal model was constructed to predict the risk of postpartum hemorrhage.The diagnostic performance was assessed using the area under the receiver operating characteristic curve (AUC) and the DeLong test. Decision curve analysis (DCA) was performed to determine the performance of the best predictive model.
Results
Eighteen radiomic features showed a strong correlation with PPH. Four MRI features were selected as clinical features.The clinicoradiomic model resulted in the best discrimination ability for risk prediction of PPH, with an AUC of 0.956 (95% CI, 0.9101.000), 0.781(95% CI, 0.606 0.955), and 0.702 (95% CI, 0.541 0.864) in the training, independent validation and external validation cohorts respectively. The clinicoradiomic nomogram, incorporating radiomics signature and four MRI features, was developed. The calibration was good and DCA confirmed the clinical utility of the nomogram.
Conclusion
Obstetricians can use the nomogram to noninvasively predict PPH and guide them in creating reasonable preoperative treatment plans.
Valproic Acid inhibits proliferation and promotes apoptosis of peripheral T cell lymphoma cells via the miRNA-3196/KCNK3 signaling axis
Authors: Peng Zhiqiang , Dong Hanzhi , Xiong Jianping
Published: July 2024

Objective
The aim of this study was to clarify the treatment effect and potential mechanism of Alproic acid (VPA) on peripheral T cell lymphomas (PTCLs).
Methods
CCK-8 and EdU were used to detect cell proliferation. The mRNA expression of miR-3196 and KCNK3 was detected by qRT-PCR. Biochemical experiments were used to detect changes in the content of ATP, lactate level, and glucose content. Flow cytometry was applied to determine the apoptotic rate and ROS levels. Western blot was used to detect the protein expression of apoptotic proteins, PI3K/AKT pathway and KCNK3. GEO database and miRTarBase and starbase2.0 software were used to identify the target genes of miR-3196.
Results
VPA greatly inhibited PTCLs cells proliferation and promoted the expression of miR-3196 in a dose-dependent manner. Compared with the control group, VPA and miR-3196 mimics significantly increased the apoptosis rate, Bax and cleaved-caspase-3 expression, lactate level, ROS expression, and glucose content (P < 0.01), and significantly decreased the cell proliferation, ATP production, and the expression of Bcl-2, p-PI3K and p-AKT (P < 0.01) in the PTCLs cells. However, the miR-3196 inhibitor had the opposite effect to VPA and mimics. Moreover, the combination of VPA and miR-3196 mimics has the most obvious effect. Moreover, KCNK3 was found to be a potential target gene of miR-3196. VPA and miR-3196 mimics significantly inhibited the expression of KCNK3(P < 0.01), and miR-3196 inhibitor the expression of KCNK3(P < 0.01). Furthermore, si-KCNK3 promoted apoptosis and inhibited proliferation and activation of PI3K/Akt signaling pathways of PTCLs cells(P < 0.01). VPA could significantly enhance the effect of si-KCNK3 in PTCLs cells(P < 0.01).
Conclusion
VPA could inhibit the expression of KCNK3 by promoting the expression of miR-3196, and then inhibit the activation of PI3K/Akt pathway, ultimately promoting apoptosis and inhibiting proliferation of PTCLs cells.
Dynamic Neuron-specific Enolase Level to Glasgow Coma Scale Score Ratio Changes: A Reliable Indicator for Long-Term Neurological Function in Diffuse Axonal Injury
Authors: Chen Weiliang , Wu Jiayi , Li Shengwen , Yao Chunyu , Su Wen , Xu Lisheng , Wang Guanjun
Published: July 2024

Background: Patients with diffuse axonal injury (DAI) are often plagued by sequelae, and the current indicators for predicting long-term neurological function are not accurate enough. Our previous studies have found that serum Neuron-specific enolase (NSE) level to Glasgow Coma Scale (GCS) score ratio(NGR) at admission could be used as an independent predictor of DAI, the purpose of this study was to explore the accuracy of dynamic changes of NGR in predicting long-term neurological function in patients with DAI.
Methods: Patients with DAI were included based on clinical MRI as the diagnostic standard, and divided into two groups according to the 6-month Extended Glasgow Outcome Scale (GOSE) as the prognosis indicator. The differences in clinical parameters between the two groups of patients were compared by Pearson correlation analysis. The trend of dynamic changes in NSE, GCS, and NGR at 1st, 3rd, 5th, 7th and 14th days after injury were shown by line graphs. The predictive efficacy of various parameters for long-term neurological function were further analyzed by receiver operator characteristic (ROC) curves.
Results: Among the 102 DAI patients, 75 (73.5%) were classified to favorable outcome group (GOSE5-8) and 27 (26.5%) to unfavorable outcome (GOSE1-4). The NSE, NGR and Marshall CT grade at the first day after injury in the favorable outcome group were significantly lower than those in the unfavorable outcome group (p = 0.005, p < 0.001, p = 0.002), but the GCS score was significantly higher than that of the latter (p = 0.006). There was a negative correlation between NGR at 1st, 3rd, 5th, 7th, and 14th days post-TBI (r1=-0.557, r3=-0.746, r5=-0.761, r7=-0.727, r14=-0.694), and the 6-month GOSE. DAI patients with a favorable outcome exhibited a gradual decline in NGR. The area under the ROC curves (AUC) of NGR at 1st, 3rd and 5th days post-TBI were 0.751, 0.913, 0.934, which were the largest among the three parameters.
Conclusions: The dynamic changes of NGR may be an accurate predictor of long-term neurological function in patients with DAI.
Trial registration: ISRCTN, ChiCTR2100044352. Registered 17 March 2021, https://www.chictr.org.cn/
Heterostructural Z-scheme cobalt molybdate/AgBr composite toward for supercapacitors
Authors: Shayeh Javad Shabani , Salari Hadi
Published: July 2024

Truncated diamond CoMoO4 for the first time was fabricated by facile template free method. Hydrothermal method was applied for support synthesis and AgBr nanoparticles was loaded by precipitation. All samples were fully characterized by physic-electro-chemical methods include XPS, XRD, EDX, HRTEM, SAED, N2 adsorption-desorption isotherms, DRS, SEM, CV and EIS. Direct Z-scheme heterojunction composite was fabricated and supercapacitive performance of composite was studied for capability to use in charge storage devices. The results show that the composite has good electrochemical conductivity and suitable charge storage capability with high stability during continues charge – discharge cycles. The results demonstrated that the increased performance might be due to the Z-scheme charge transfer mechanism inside the heterojunction, which can moderate the direction of charge migration, boost charge transfer, and maintain the high redox capacity. The Electrochemical studies show that presence of AgBr, increase the electrical conductivity of CoMoO4 electrode. Enhancing the specific capacitance of electrode from 114 for CoMoO4 to 304 F.g− 1 for electrode and increasing the mechanical stability of composite one are some benefits of using AgBr in CoMoO4 system.