bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, Synthesis, In vitro and In vivo Evaluation of New Imidazo[1,2-a]pyridine
Derivatives as Cyclooxygenase-2 Inhibitors
Authors: Ahmadi Nahid , Khoramjouy Mona , Azami Movahed Mahsa , Amidi Salimeh , Faizi Mehrdad , Zarghi Afshin
Published: January 2024

Background:

Cyclooxygenase-2 (COX-2), the key enzyme in the arachidonic acid conversion to prostaglandins,
is one of the enzymes associated with different pathophysiological conditions, such as inflammation,
cancers, Alzheimer's, and Parkinson's disease. Therefore, COX-2 inhibitors have emerged as potential therapeutic
agents in these diseases.

Objectives:

The objective of this study was to design and synthesize novel imidazo[1,2-a]pyridine derivatives
utilizing rational design methods with the specific aim of developing new potent COX-2 inhibitors. Additionally,
we sought to investigate the biological activities of these compounds, focusing on their COX-2 inhibitory effects,
analgesic activity, and antiplatelet potential. We aimed to contribute to the development of selective COX-2 inhibitors
with enhanced therapeutic benefits.

Methods:

Docking investigations were carried out using AutoDock Vina software to analyze the interaction of
designed compounds. A total of 15 synthesized derivatives were obtained through a series of five reaction steps.
The COX-2 inhibitory activities were assessed using the fluorescent Cayman kit, while analgesic effects were
determined through writing tests, and Born's method was employed to evaluate antiplatelet activities.

Results:

The findings indicated that the majority of the tested compounds exhibited significant and specific inhibitory
effects on COX-2, with a selectivity index ranging from 51.3 to 897.1 and IC50 values of 0.13 to 0.05 μM.
Among the studied compounds, derivatives 5e, 5f, and 5j demonstrated the highest potency with IC50 value of
0.05 μM, while compound 5i exhibited the highest selectivity with a selectivity index of 897.19. In vivo analgesic
activity of the most potent COX-2 inhibitors revealed that 3-(4-chlorophenoxy)-2-[4-(methylsulfonyl) phenyl]
imidazo[1,2-a]pyridine (5j) possessed the most notable analgesic activity with ED50 value of 12.38 mg/kg. Moreover,
evaluating the antiplatelet activity showed compound 5a as the most potent for inhibiting arachidonic acidinduced
platelet aggregation. In molecular modeling studies, methylsulfonyl pharmacophore was found to be
inserted in the secondary pocket of the COX-2 active site, where it formed hydrogen bonds with Arg-513 and
His-90.

Conclusion:

The majority of the compounds examined demonstrated selectivity and potency as inhibitors of
COX-2. Furthermore, the analgesic effects observed of potent compounds can be attributed to the inhibition of
the cyclooxygenase enzyme.
Efficacy of Dyslipidemia Control by Combination Therapy with Rosuvastatin 10 Mg and Ezetimibe 10 Mg Compared with Rosuvastatin 20 Mg Monotherapy in Patients with Chronic Coronary Syndromes: A Randomized, Single-blind Controlled Trial
Authors: Tran An Viet , Tran Bao Lam Thai , Bui Nghia Minh , Le Anh To Tan , Nguyen Diem Thi , Tran Son Kim , Ngo Toan Hoang
Published: January 2024

Background:

Studies have shown the combination treatment effectiveness of using
rosuvastatin and ezetimibe in patients with chronic coronary artery disease. Our study aim to evaluate
the effectiveness of dyslipidemia treatment with the combination of rosuvastatin and ezetimibe
10mg in patients with chronic coronary artery disease compared with 20 mg rosuvastatin.

Objectives:

To evaluate the effectiveness of dyslipidemia treatment with the target of LDL-c <
1.4 mmol/L between combination therapy with rosuvastatin 10 mg and ezetimibe 10 mg in patients
with chronic coronary artery disease compared with monotherapy increasing the dose of
rosuvastatin 20 mg in Vietnam.

Methods:

A randomized controlled clinical trial, single-blind, parallel-group with a 1:1 randomized
ratio in 103 outpatients with chronic coronary syndromes treated with rosuvastatin 10mg
daily. Group A received the combination therapy with rosuvastatin 10 mg plus ezetimibe 10 mg
daily, and group B received rosuvastatin 20 mg daily. The primary outcome was to assess the
efficacy of low-density lipoprotein – cholesterol (LDL-c) control between rosuvastatin 10 mg
plus ezetimibe 10 mg versus rosuvastatin 20 mg after 4 weeks and 8 weeks.

Results:

After 8 weeks of intervention, the proportion of archived treatment target patients with
LDL-c < 1.4 mmol/L in groups A and B was 69.2% and 44.2%, respectively (Risk ratio (RR) =
1.57, p < 0.01), 50% LDL reduction was 27.9% and 55.8%, respectively (RR = 2.00, p < 0.01),
and archived both targets were 51.9% and 25.6% (RR = 2.03, p < 0.01).

Conclusion:

Group A's LDL-c reduction effect and target achievement proportion (Rosuvastatin
10mg + Ezetimibe 10 mg) were significantly higher than Group B's (Rosuvastatin 20 mg). Both
medication therapies were safe in patients, and the increased dose of monotherapy showed more
side effects than the combination therapy.

Clinical Trail Registration Number:

ISRCTN44571.
Green Synthesis of Silver Nanoparticles using Coriandrum sativum and
Murraya koenigii Leaf Extract and its Thrombolytic Activity
Authors: Pram Priyanca , Mishra Nikita , Vaithilingam Mohanasrinivasan , Samuel Merlyn Keziah , Mohanan Maneesha , Kothari Neeti , Chandrasekaran Subathra Devi
Published: January 2024

Background:

Plants have been used for ages in traditional medicine, and it is exciting
to perceive how recent research has recognized the bioactive compounds liable for their beneficial
effects. Green synthesis of metal nanoparticles is a hastily emergent research area in nanotechnology.
This study describes the synthesis of silver nanoparticles (AgNPs) using Coriandrum
sativum and Murraya koenigii leaf extract and its thrombolytic activity.

Objective:

The aim of the study was to determine the clot lysis activity of Coriandrum sativum
and Murraya koenigii synthesized silver nanoparticles.

Methods:

Leaves of Coriandrum sativum and Murraya koenigii were collected. Methanolic extraction
of the plant sample was done through a Soxhlet extractor. The methanolic extract obtained
from both the leaves was subjected to GC-MS analysis. The synthesized NPs from leaf
extracts were monitored for analysis, where the typical X-ray diffraction pattern and its diffraction
peaks were identified. 3D image of the NPs was analysed by Atomic Force Microscopy. The
surface charge of nanoparticles was identified by Zeta potential. The Clot lysis activity of Coriandrum
sativum and Murraya koenigii synthesized silver nanoparticles were analysed by the
modified Holmstorm method.

Results:

The thrombolytic property of the methanolic extract of plants Coriandrum sativum
showed clot lysis activity at 2.5 mg/mL with 45.99% activity, and Murraya koenigii extract with
66.56% activity. The nanoparticles (Nps) from Coriandrum sativum showed clot lysis activity at
2.5 mg/mL with 58.29% activity, and NPs from Murraya koenigii with 54.04% activity. Coriandrum
sativum in GC-MS exhibited 3 peaks, whereas Murraya koenigii extract showed five peaks
with notable bioactive compounds.

Conclusion:

These NPs were further used for biomedical applications after being fixed by an
organic encapsulation agent. The present research reveals the usefulness of Coriandrum sativum
and Murraya koenigii for the environmentally friendly manufacture of silver nanoparticles.
In silico Identification of MHC Displayed Tumor Associated Peptides in
Ovarian Cancer for Multi-Epitope Vaccine Construct
Authors: Dobhal Shivashish , Chauhan Kanchan , Kumar Sachin , Shikha Sristy , Jogi Mukesh K. , Kumar Dinesh , Kumar Anuj , Jaiswal Varun K. , Kumar Pramod
Published: January 2024

Background:

Recognizing the potential of the immune system, immunotherapies
have brought about a revolution in the treatment of cancer. Low tumour mutational burden and
strong immunosuppression in the peritoneal tumor microenvironment (TME) lead to poor outcomes
of immune checkpoint inhibition (ICI) and CART cell therapy in ovarian cancer. Alternative
immunotherapeutic strategies are of utmost importance to achieve sound clinical success.

Introduction:

The development of peptide vaccines based on tumor-associated antigens (TAAs)
for ovarian cancer cells can be a potential target to provoke an anti-tumor immune response and
subsequent clearance of tumour cells. The purpose of this in-silico study was to find potential
epitopes for a multi-epitope vaccine construct using the immunopeptidomics landscape of ovarian
carcinoma.

Methods:

The four TAAs (MUC16, IDO1, FOLR1, and DDX5) were selected for potential
epitopes prediction. The epitopes for B-cells, helper T-lymphocytes (HTL), and Cytotoxic Tlymphocytes
(CTL) were predicted on the basis of antigenic, allergenic, and toxic properties. These
epitopes were combined with suitable linkers and an adjuvant to form a multi-epitope construct.

Results:

Four HTLs, 13 CTLs, and 6 potential B-cell epitopes were selected from the predicted
epitope. The designed multi-epitope construct was potentially immunogenic, non-toxic, and
non-allergenic. Physicochemical properties and higher-order structural analyses of the final construct
revealed a potential vaccine candidate.

Conclusion:

The designed vaccine construct has the potential to trigger both humoral and cellular
immune responses and may be employed as a therapeutic immunization candidate for ovarian
malignancies. However, further in vitro and animal experimentation is required to establish
the efficacy of the vaccine candidate.
On the Improvements of the Performance of Bayes-Net Classification for Diagnosis of Diabetes: A Cross-validation Approach
Authors: Verma Sarvachan , Sharma Anupama , Jain Sachin , Kumar Anuj
Published: January 2024

Introduction:

This study intends to support medical professionals in the early and precise
detection and diagnosis of type1 and type2 Diabetes. Many complexities occur if Diabetes is
unidentified and remains untreated. 9.3% of individuals worldwide have Diabetes as of 2019, according
to data from the World Health Organization. The anticipated increase would be close to
11% of the global population by 2045.

:

Diabetes mellitus is a chronic, one of the deadliest diseases that causes Body blood glucose levels
to be above average level knowing a blood sugar. Diabetes can be type1 (T1D) and type2(T2D).
An autoimmune condition called Type 1 diabetes is frequently found in young children. Adults
are frequently diagnosed with type 2 diabetes, which is not autoimmune. A branch of artificial
intelligence called machine learning has the potential to be successful in the field of predictions.

Methos:

This research aims to design a machine learning model to predict Diabetes in a patient.
The collective performance of the four algorithms is evaluated on various measures like accuracy,
precision, sensitivity, and specificity. Therefore, four machine learning classification algorithms,
namely Bayes-Net, Naïve-Bayes, J48, and Random Forest, were used to predict Diabetes
in the early stage using 10–fold cross validation.

Results:

For experiments, a standard PIMA Indian diabetes dataset is used. According to the results,
Bayes-Net performs better than other algorithms, with an accuracy rate of 87.72%.

Conclusion:

Diabetes Mellitus may harm kidneys, nerves, eyes, and other organs if it is not diagnosed
in time. Therefore, early diagnosis and treatment could save countless lives. The process
is tedious because patients visit a diagnostic facility and see a doctor, but various machine learning
and deep learning approaches solve this clinical problem earlier.
Optimized Maximum Power Point Tracking using Giza Pyramid Construction Algorithm for Photovoltaic Systems
Authors: Soma Keerthi Sonam , Ramadoss Balamurugan , Natarajan Karuppiah
Published: January 2024

Background:

One of the key challenges in maximizing the performance of PV systems
is the efficient tracking of the maximum power point (MPP) under varying operational conditions,
including changes in solar irradiance and temperature. Accurate MPP tracking is essential for
achieving optimal energy conversion efficiency and maximizing the electricity generation potential
of the PV array, even during partial shading conditions. Traditional maximum power point
tracking (MPPT) algorithms, such as the incremental conductance (INC) method, often struggle to
efficiently handle partial shading conditions. As a result, there is a need for more sophisticated
and robust optimization techniques that can effectively address this challenge. This study presents
a novel and innovative Giza Pyramid Construction (GPC) algorithm to solve the partial shadinginduced
MPP tracking problem.

Objective:

This study aims to apply the Giza Pyramid Construction (GPC) algorithm for optimized
maximum power point tracking in photovoltaic systems under partial shading conditions,
aiming to enhance energy conversion efficiency and overall system performance.

Methods:

The methodology involves implementing the Giza Pyramid Construction (GPC) algorithm
as the core optimization technique for maximum power point tracking (MPPT) in photovoltaic
(PV) systems. The GPC algorithms are utilized to iteratively adjust the duty cycle of the boost converter,
enabling efficient power extraction from the PV array under varying shading conditions. The
performance of the GPC algorithm is evaluated through simulations in MATLAB/SIMULINK and
compared against conventional MPPT methods like INC and DGO techniques.

Results:

The successful application of the Giza Pyramid Construction (GPC) algorithm for optimized
maximum power point tracking in PV systems under partial shading led to significantly
reduced optimization time, faster settling times, and minimized output ripples. With the proposed
GPC MPPT, optimization time is reduced to 41ms, settling time is reduced to 93ms, and ripples
are minimized to 0.092%.

Conclusion:

the Giza Pyramid Construction (GPC) algorithm demonstrates its effectiveness as a
robust and efficient maximum power point tracking method in photovoltaic systems, particularly
under partial shading conditions. The improved optimization speed, reduced settling times, and
minimized output ripples underscore the GPC algorithm's potential to enhance the overall efficiency
and reliability of PV systems, paving the way for its practical implementation in real-world
renewable energy applications.
Disease Modifying Strategies in Multiple Sclerosis: New Rays of Hope to
Combat Disability?
Authors: Bellanca Carlo Maria , Augello Egle , Mariottini Alice , Bonaventura Gabriele , La Cognata Valentina , Di Benedetto Giulia , Cantone Anna Flavia , Attaguile Giuseppe , Di Mauro Rosaria , Cantarella Giuseppina , Massacesi Luca , Bernardini Renato
Published: January 2024

Multiple sclerosis (MS) is the most prevalent chronic autoimmune inflammatory- demyelinating
disorder of the central nervous system (CNS). It usually begins in young adulthood, mainly
between the second and fourth decades of life. Usually, the clinical course is characterized by the involvement
of multiple CNS functional systems and by different, often overlapping phenotypes. In the
last decades, remarkable results have been achieved in the treatment of MS, particularly in the relapsing-
remitting (RRMS) form, thus improving the long-term outcome for many patients. As deeper
knowledge of MS pathogenesis and respective molecular targets keeps growing, nowadays, several
lines of disease-modifying treatments (DMT) are available, an impressive change compared to the relative
poverty of options available in the past. Current MS management by DMTs is aimed at reducing
relapse frequency, ameliorating symptoms, and preventing clinical disability and progression. Notwithstanding
the relevant increase in pharmacological options for the management of RRMS, research
is now increasingly pointing to identify new molecules with high efficacy, particularly in progressive
forms. Hence, future efforts should be concentrated on achieving a more extensive, if not exhaustive,
understanding of the pathogenetic mechanisms underlying this phase of the disease in order to characterize
novel molecules for therapeutic intervention. The purpose of this review is to provide a compact
overview of the numerous currently approved treatments and future innovative approaches, including
neuroprotective treatments as anti-LINGO-1 monoclonal antibody and cell therapies, for effective and
safe management of MS, potentially leading to a cure for this disease.
The role of different types of knowledge in the text comprehension when reading (experience of experimental interpretative observation)
Authors: Popadinets R. V.
Published: January 2024

The article discusses the problem of studying knowledge, as well as the role of different types of knowledge in the text comprehension. In terms of theory, the purpose of this paper is to review the scientific literature on the problem of knowledge, their classification. On the practical side, the purpose of the article is to analyze the role of different types of knowledge in the process of the comprehension of a particular text when reading by a study population, as well as to identify some strategies and principles that students could be guided by when faced with the problem of adequate perception and comprehension of foreign-language texts.The paper applied the method of experimental interpretative observation using a private psycholinguistic empirical questionnaire method, involving interviewing and conversation with subjects under study, during which actual data were obtained. On the basis of these empirical data, the main theoretical and practical conclusions were builtThe article analyzed a certain amount of scientific literature on the problem of knowledge and its classification.It was found out that the problem of knowledge had been dealt with for a long time and there are quite a lot of controversial and unresolved issues in this area: problems of storing, using and acquiring knowledge. It was also found in the work that there are quite a large number of classifications of knowledge, the bases for these classifications, which often overlap.Based on the results of the practical study, some conclusions were drawn. Those conclusions imply that in the process of semantic perception and comprehension of the text when reading, which is an active process, the study population activate and apply numerous knowledge. In the process of reading the text, they also resort to certain strategies and principles of working with it. This allowed us to develop certain recommendations that students could apply when comprehending foreign-language text information. This problem is highly relevant due to the fact that the problem of adequate perception and comprehension of the text is important as one of the problems that determine the effectiveness of both teaching and learning a foreign language in an educational institution. In addition, knowledge of strategies and principles of understanding textual information could facilitate communication in a foreign language in real speech situations.
Neologisms in Polycode Text of Image Advertising: Some Peculiarities of the USE in the Context of Media Sphere
Authors: Annenkova A. V.
Published: January 2024

The article considers the problem of neologisms functioning in mass media on the material of image advertising texts. The relevance is determined by the importance of advertising communication as an integral part of modern society, as well as the need to study the peculiarities of compositional structure of polycode texts of image advertising, in particular, correlation of verbal and nonverbal parts of an advertising text involved in the process of influencing an individual to manipulate both the collective behavior and consciousness.Development of globalization processes, availability of Internet and mass media could not but affect the advertising language having transformed it by introducing neologisms which are used in everyday language but not quite familiar to the majority. Newly coined words can be both Russian derivatives and borrowings. The purpose of the research is to study some peculiarities of neologisms usage in polycode texts of image advertising as well as to define a system forming factor in the structure of verbal/nonverbal that influences formation of an advertising objects image in an individual lexicon. The objectives of the study are to consider the notion of image, image advertising and its structural and compositional features along with the analysis of cognitive-psychological influence of images formed by neologisms combined with iconic signs on an individual.The need in reasoned influence on the individual when advertising has led to hybridization of the advertising text which became a complex and integrated textual entity with the integration of verbal and non-verbal elements.The analysis of image advertising language material showed that neologisms when correlating with other verbal and visual/graphic elements develop and/or adapt associative connections and internal images behind the image in an individual lexicon
Knowledge-Intensive Market: Geomarketing and Cluster Approach to Functioning and Analysis
Authors: Pryadko S. N. , Kucheryavenko S. A.
Published: January 2024

Relevance. Innovative development is one of the highest priority tasks of the economy at the national and regional level. One of the directions for solving these problems is the formation of local knowledge-intensive markets, within which the interaction of the main participants in the innovation cycle takes place - from conducting fundamental scientific research to introducing a knowledge-intensive product to the market. The object of the study was the local knowledge-intensive market of the Belgorod region. The sources of information for the study were data from the World Intellectual Property Organization (WIPO); research results presented in the eLibrary.Ru search engine; data from statistical reporting of the Territorial Body of the Federal State Statistics Service for the Belgorod Region.The purpose of the study is a cluster grouping of developed advanced production technologies in organizations of the Belgorod region.Objectives: content analysis of theoretical data on the research problem in the eLibrary.Ru search engine; analysis of thematic publications and regulatory documents, data from foreign countries; classification of tools for analyzing indicators of knowledge-intensive markets; grouping of quantitative indicators; testing of research results in the conditions of a regional knowledge-intensive market.Methodology. Retrospective content analysis, static data analysis, cluster analysis and grouping of developed advanced production technologies in organizations of the Belgorod region were used as research methods.Results. The article presents a brief analysis of the effectiveness of implementing these tasks from the perspective of geomarketing and cluster approaches. The main stages of the formation of cluster policy in the Russian Federation are highlighted and the conditions for the formation of this policy at the national level are analyzed. As a result of the research, the main geomarketing tools for analyzing the local knowledge-intensive market were structured; a grouping of quantitative parameters is proposed for conducting geomarketing and cluster analysis of a knowledge-intensive local market.Conclusion. Based on cluster analysis, advanced production technologies used in the region were grouped into four clusters, which can become the basis for further innovative development.
A Dynamic Model of Personal Adaptive Potential in the Conditions of Media Ecosystem
Authors: Grimov O. A.
Published: January 2024

Relevance. The modern stage of information and communication technology development is attracting more and more researchers’ attention to the problem of risk causing factors that arise during the process of digitalization and mediatization. The category of adaptive potential that is used in various fields of socio-humanitarian knowledge appears to be an adequate conceptual instrument for media ecosystem risk problematization. However, in the framework of humanitarian and scientific digitalization discourse this concept is underdeveloped, and this fact determines the relevance of the theoretical construction(model) of personal adaptive potential in the conditions of media ecosystem, as well as the promising directions of its application.The purpose of the article is theoretical substantiation and construction of a dynamic model of an individual's adaptive potential to the risks of the media ecosystem.Objectives: to reveal the theoretical and methodological foundations of personal adaptive potential conceptualization in the conditions of media ecosystem; to specify the contents of adaptive potential levels; to describe adaptive potential dynamic interrelations with the corresponding parameters of the media ecosystem.Methodology. In the article sociological theories that focus on the socio-constructionist nature of modern technologies (actor-network theory, social construction of technology theory) are applied; as well as a number of basic general scientific methods (inductive and deductive methods, structural and functional approach). Special attention is paid to the methods of analogy and modeling, which made it possible to create a dynamic model of the adaptive potential of the individual in the media ecosystem and to lay the foundations for further operationalization of this category.Results. Basing on the results of the theoretical sources study, the author has constructed a dynamic model of personal adaptive potential. The article describes the value, dispositional and practical levels of adaptive potential, as well as their relationship with the corresponding parameters of the media ecosystem (institutional norms and habituses, patterns, affordances).Conclusions. The dynamic model constructed can be used as a methodological basis for theoretical and applied research. A promising direction is further operationalization and empirical verification of the model presented, as well as explication of adaptive potential structural elements.
Career Expectations of Russian and Chinese Students in Conditions of Social Risks
Authors: Kilimova L. V. , Cherkashin M. D. , Li I.
Published: January 2024

Relevance. For modern Russia, the problem of a career for young people is especially acute due to the unpredictability and unpredictability of external circumstances in which career processes are carried out. The formation of a personality is impossible without an established positive attitude towards work, readiness to acquire a particular profession. The profession sets a certain social background for people's lives. And therefore, many young people, when choosing a career, link their future profession and their possible material well-being.The purpose of the work is to identify the characteristics of the influence of career expectations on the professional choice of Russian and Chinese students in conditions of social risks.Objectives: to identify the specifics of career expectations of students in Russia and China; carry out a comparative analysis of the features of the influence of career expectations on the professional choice of Russian and Chinese students.Methodology. The methodological basis of the article is: a systematic method that allows us to identify the main elements of the external environment that determine the specifics of professional orientations of modern students; a comparative method reflecting the characteristics of the career expectations of Russian and Chinese students.Results. The paper reveals behavioral patterns that determine the dynamics of career expectations of Russian and Chinese students, accompanied by both positive and negative effects in professional self-realization; The results of the study made it possible to see the different orientations of the student youth of the two countries when making a professional choice, which are not only representatives of the new generation, but also representatives of two different civilizations: Eastern and Western.Conclusions. For Chinese university students overall, the results show that the top six career expectations include: equality of opportunity and fair competition; high income; provision of health care, pension and housing funds; good perks; satisfaction of hobbies and interests; opportunity to use their talents. For Russian students, the choice of a stable place of work prevails, and they also show a high interest in leadership activities, the ability to organize the work of other people, and have a high social status.
Theoretical Foundations of the Modern Multi-Level Model Management of the Process of Innovative Development in the Russian Federation
Authors: Zhakhov N. V. , Markov D. A.
Published: January 2024

Relevance. The article is devoted to the research and development of a multi-level model of innovative development of the regions of the Russian Federation. The relevance of the transition to an innovative path of development of the Russian economy in the context of exogenous, global changes, geopolitical instability was especially noted.The purpose is to develop a multi-level model of innovative development, with the allocation of the most promising levels of managerial decision-making.Objectives: analysis of the main levels of the existing multi-level model of innovative development of the territory; identification of key institutional constraints and problems of practical implementation of the current model of innovative development of Russian regions; development of a structural-logical scheme for the formation of a multilevel model of innovative development; highlighting the main elements of the local level of development of innovations at specific enterprises, industries.Methodology. In the course of the work, a wide range of research methods, theoretical concepts in the field of spatial and innovative development of territories were used. The dialectical, systematic and integrated approach became the main ones, which made it possible to consider economic relations in interconnection and development, to comprehensively assess the research problem under consideration.Results. The transition of regional economic systems to an innovative path of development is an important priority for the socio-economic development of the country, while the complexity of implementing innovation policy at different levels (federal, regional, and local) is revealed, and many factors affecting efficiency are identified. and the effectiveness of these processes. In contrast to the prevailing approach, where regions are considered as the main level of innovation, this study proposes to single out the level of agglomerations of municipalities as the most promising and relevant for the transition to an innovative path of development of regional economic systems.Conclusions. The main purpose of introducing the presented model into the practice of managing socioeconomic development is to activate internal reserves by means of using the potential of the designated agglomerations of municipalities. The results of the study indicate that countries with a high level of development of production successfully use a multi-level regulatory system aimed at the transition to an innovative path of development of regional economic systems.
O sujeito alienado em 3D
Authors: Penteado Claudio Luis de Camargo , De Miranda Pinto Rafael Akio
Published: January 2024

Este texto trata da produção de um novo sujeito alienado através da reconfiguração do capitalismo contemporâneo. Pelo exame do impacto das Tecnologias de Informação e Comunicação da atualidade, nas lógicas de exercício do poder pelo capital, é apresentado como a cooptação material e ideológica da internet cria um sistema de dominação tridimensional (econômica política e cultural). Por fim, sugere como grandes empresas de tecnologia, motivadas pelo lucro, comodificam a sociabilidade dos indivíduos através de mídias sociais, fazendo com que todo o produto social nesses ambientes seja alienado do indivíduo, ao ser espoliado, processado e convertido em valor.
papel político do jornalismo
Authors: Tavares Camilla Quesada
Published: January 2024

O trabalho tem como objetivo discutir o papel das convicções da Gazeta do Povo na rotina de produção jornalística do referido veículo. Com o anúncio do fim do impresso veio também a apresentação pública das convicções sobre determinados temas, como o papel do estado na sociedade, a constituição familiar e o aborto. O novo projeto do veículo é a primeira iniciativa do tipo na América Latina, e é baseado no modelo de negócios voltado para as assinaturas digitais e não para a publicidade, tendo como foco a audiência nacional. Para atingir os objetivos propostos, a pesquisa adota a metodologia qualitativa, a partir da análise das entrevistas em profundidade realizadas com 15 profissionais entre outubro de 2017 e agosto de 2018. Os resultados indicam que as convicções incidem de formas distintas nas editorias, e que há um núcleo constituído de editorias chaves que têm por objetivo “vender” as convicções a partir da produção jornalística. Isso demonstra o papel político desempenhado pelo jornalismo praticado dentro da Gazeta do Povo.
Biografias de atores políticos brasileiros como estratégia editorial em cenários eleitorais
Authors: Adam Felipe , Gadini Sérgio Luiz
Published: January 2024

O artigo verifica como os jornalistas brasileiros recontam a trajetória dos atores políticos em obras biográficas, em momentos de disputa eleitoral. A perspectiva metodológica da jornada do herói, elaborada por Joseph Campbell, em diálogo com a proposição de Edvaldo Pereira Lima, orienta a reflexão. As narrativas que ilustram o texto são os livros “A história de Lula, o filho do Brasil, de Denise Paraná, “A vida quer é coragem: A trajetória de Dilma Rousseff, a primeira presidenta do Brasil”, assinado por Ricardo Batista Amaral, e “Bolsonaro: O homem que peitou o exército e desafia a democracia”, de Clóvis Saint-Clair. Como resultado, constata-se que as biografias funcionam como um instrumento de divulgação para quem deseja ser lembrado pelos eleitores, às vezes, semelhante à idolatria. Ademais, os biografados são tratados como predestinados, que não têm problemas ou contradições na trajetória política descrita.
Fake news e mundos de pós-verdade
Authors: Santos Nina
Published: January 2024

Fake news e pós-verdade viraram termos correntes do debate contemporâneo como símbolos de ameaças às democracias. O que Johan Farkas e Jannick Schou fazem no livro “Post-truth, fake news and democracy. Mapping the politics of falsehood” é questionar a ideia de democracia que subjaz a esses discursos e propor um deslocamento do debate. Os autores adotam uma abordagem pós-fundacionalista da teoria do discurso para analisar mais de 500 textos sobre fake news e pós-verdade publicados entre 2015 e 2018. Eles defendem que as críticas a esses processos estão majoritariamente fundadas em uma visão racional da democracia, que tende a despolitizar esses processos. Ao defender que a base dos regimes democráticos não é a verdade e sim a soberania popular, eles argumentam que centrar o debate apenas na retomada de uma certa racionalidade pode ser um caminho perigoso para as democracias
benefícios de olhar além das fronteiras
Authors: Hauber Gabriella
Published: January 2024

Entrevista com o professor Hartmut Wessler.
“Mesmo solto, Lula nunca será livre”:
Authors: Dibai Priscilla Cabral
Published: January 2024

Este artigo discute a repercussão em torno da soltura da prisão do ex-presidente Lula, em comunidade on-line de partidários de Jair Bolsonaro, no Telegram. Além dos sentidos e inimigos construídos, foi observado ainda certos padrões comunicativos e o potencial para a radicalidade existente no grupo. Por meio da análise de conteúdo, foi detectada uma contundente narrativa de indignação e inconformismo envolvendo o STF e Lula, que têm suas imagens atacadas e desacreditadas. Os partidários do grupo tendem a usar o recurso da desinformação intencional, bem como linguagem ofensiva para se referir e modalizar os adversários, além de superestimar o próprio poder e o líder, construindo distintas saídas para a derrota: de reanimação da militância a pedidos de intervenção militar.
Prefeitura de Florianópolis no Facebook
Authors: Comel Naiza , Brodbeck Pedro , Quadros Claudia
Published: January 2024

Como fonte de informação para grande parte de seus usuários, o Facebook passa a ter importância também nas estratégias de comunicação de prefeituras. Neste artigo, resgatamos alguns estudos sobre o tema para pesquisar a página da Prefeitura de Florianópolis, identificando conteúdos, formatos e refletindo sobre a interação e a transparência. Capital de Santa Catarina, o município possui 477 mil habitantes, com uma fanpage que tem quase 234 mil seguidores. Com base no conceito de Comunicação Pública e em debates sobre o uso de redes sociais por órgãos públicos, utiliza-se como procedimento metodológico a observação sistemática e a Análise de Conteúdo. Observamos que a rede social é usada como uma espécie de ferramenta de transparência, pois há um esforço para a divulgação das ações governamentais. No entanto, há um número reduzido de posts com links para dar mais detalhes ao cidadão.
defesa de quê?
Authors: Santos Jonatha Vasconcelos
Published: January 2024

O presente artigo analisa o uso das diversas narrativas produzidas em torno da Covid-19 como forma de pressão sob a gestão da crise da pandemia. Para isso, investigamos as cartas públicas, relatórios de pesquisa e planos de ação elaboradas por grupos sociais como i) os “ativistas pela vida”, ii) os pesquisadores, iii) os empresários e iv) o governo de Sergipe. Paralelamente a isso, e como forma de identificar como essas narrativas afetam a gestão estatal da pandemia, analisamos o processo de construção dos grupos mencionados e a participação desses atores sociais em espaços deliberativos como os comitês de crise. Os resultados sinalizam para a forma como os diversos enquadramentos interpretativos foram utilizados, de forma pública, como dispositivo de intervir nas ações governamentais em torno do enfrentamento à pandemia.
Jornalismo de dados e a qualidade dos Dados Abertos governamentais no Brasil
Authors: Silva Sivaldo Pereira da , Santos Ébida , Dominguez Maria , Lima Patrícia
Published: January 2024

Este artigo tem como objetivo caracterizar a experiência de jornalistas no reúso de dados abertos governamentais para a produção de conteúdos. O trabalho traz uma pesquisa qualificada com 51 profissionais com dados coletados a partir da aplicação de survey e entrevista estruturada, com análise exploratória do tipo quantiqualitativa. Os resultados demonstram que “arquivos desatualizados”, “falta de inteligibilidade” e “informação incompleta” são as disfunções mais recorrentes e destacadas como um grande problema para mais de 60% dos entrevistados. Cerca de 94% dos entrevistados afirmaram que já desistiram de uma pauta devido a problemas na qualidade dos datasets. O estudo conclui haver obstáculos reais no nível prático que afeta a qualidade das informações publicadas e seu efetivo reúso.
política do anti
Authors: Schiaffarino Júlia , Guazina Liziane
Published: January 2024

Este artigo identifica conteúdos Antipolítica e Antistablishment em vídeos postados por João Doria no Facebook durante a campanha de 2016 à prefeitura de S. Paulo. Construirmos um mapa teórico com características de tais conceitos e por análise de conteúdo observamos a presença delas em um conjunto de 81 vídeos. Verificamos como Doria adotou o modus operandi de uma “política do anti”, na qual o conteúdo antiestablishment foi usado para validá-lo eleitoralmente e o antipolítico para o alcance de engajamento nas redes.
mandatos da antipolítica
Authors: Silva Joscimar
Published: January 2024

Na última década (2010-2020) novas lideranças políticas se candidataram a cargos públicos convertendo a visibilidade nas mídias sociais digitais para a representação política. Este artigo analisa a interação entre lideranças políticas digitais e seus seguidores durante os mandatos. A partir de mineração de dados, foram estudados os casos de Kim Kataguiri e Joyce Hasselmann (Brasil) e Samuel Garcia (México). Os resultados apontam que essas lideranças mantêm o discurso antissistema e forte personalismo político nos espaços de representação política e discute esse novo tipo de representante político no conturbado contexto de acirramento da crise de representação e de aumento da população conectada às mídias sociais digitais.
The Urgent Need for an Evidence-Based Digital Mental Health Practice Model of Care for Youth
Authors: Ridout Brad , Forsyth Rowena , Amon Krestina L , Navarro Pablo , Campbell Andrew J
Published: January 2024

Australian providers of mental health services and support for young people include private and public allied health providers, government initiatives (eg, headspace), nongovernment organizations (eg, Kids Helpline), general practitioners (GPs), and the hospital system. Over 20 years of research has established that many young people prefer to seek mental health support online; however, clear client pathways within and between online and offline mental health services are currently lacking. The authors propose a Digital Mental Health Practice model of care for youth to assist with digital mental health service mapping. The proposed model offers accessible pathways for a client to engage with digital mental health services, provides clear navigation to access support for individual needs, and facilitates a seamless connection with offline mental health services using a transferable electronic health records system. This future-looking model also includes emerging technologies, such as artificial intelligence and the metaverse, which must be accounted for as potential tools to be leveraged for digital therapies and support systems. The urgent need for a user-centered Digital Mental Health Practice model of care for youth in Australia is discussed, highlighting the shortcomings of traditional and existing online triage models evident during the COVID-19 pandemic, and the complex challenges that must be overcome, such as the integration of diverse mental health care providers and establishment of a robust electronic health records system. Potential benefits of such a model include reduced pressure on emergency rooms, improved identification of immediate needs, enhanced referral practices, and the establishment of a cost-efficient national digital mental health care model with global applicability. The authors conclude by stressing the consequences of inaction, warning that delays may lead to more complex challenges as new technologies emerge and exacerbate the long-term negative consequences of poor mental health management on the economic and biopsychosocial well-being of young Australians.
BrighterSide: A randomised controlled trial of a self-guided app for suicidal ideation (Preprint)
Authors: Josifovski Natasha , Torok Michelle , Batterham Philip , Wong Quincy , Beames Joanne , Theobald Adam , Holland Sarah , Huckvale Kit , Riley Jo , Cockayne Nicole , Christensen Helen , Larsen Mark
Published: January 2024

BACKGROUND

Self-guided digital interventions can reduce the severity of suicidal ideation, although there remain relatively few, rigorously evaluated, smartphone apps targeting suicidality.

OBJECTIVE

This trial evaluated whether the BrighterSide® smartphone app intervention was superior to a waitlist control group at reducing the severity of suicidal ideation.

METHODS

550 adults aged 18-65 with recent suicidal ideation were recruited from the Australian community. In this randomized controlled trial, participants were randomly assigned to receive either the BrighterSide® intervention app, or to a waitlist control group which involved treatment as usual. The app was self-guided, and participants could use the app at their own pace for the duration of the study period. Self-report measures were collected at baseline, 6-weeks, and 12-weeks. The primary outcome was severity and frequency of suicidal ideation, and secondary outcomes included psychological distress and functioning and recovery. Additional data were collected on app engagement and participant feedback.

RESULTS

Suicidal ideation reduced over time for all participants, but there was no significant interaction between group and time. Similar improvements were observed for self-harm, functioning and recovery, days out of role, and coping. Psychological distress was significantly lower in the intervention group at the 6-week follow-up, but this was not maintained at 12 weeks.

CONCLUSIONS

The BrighterSide® app did not lead to a significant improvement in suicidal ideation, relative to a waitlist control group. Possible reasons for this null finding are discussed.

CLINICALTRIAL

Australian New Zealand Clinical Trials Registry (ACTRN12621000712808).
Pengaruh edukasi gizi terhadap pengetahuan gizi atlet remaja di Indonesia
Authors: Penggalih Mirza Hapsari Sakti Titis , Sofro Zaenal Mutaqqien , Trisnantoro Laksono , Susila Edi Nurinda , Ernawaty Ernawaty , Rahadian Bayu , Margono Margono , Sujadi Dadi , Isnanta Raden , Bactiar Nia , Anugraheni Ayudiva Rizky , Budiarjo Theresa
Published: January 2024

The impact of providing nutrition education on the nutritional knowledge of young athletes in IndonesiaBackground: A lack of nutritional knowledge can lead to poor eating habits and nutritional deficiencies in young athletes. One of the issues leading to athletes' need for more knowledge is the absence of professional assistance in educating them about nutrition. Objective: This research was analyzed to investigate the impact of nutrition education through counseling and group-based nutrition education on the nutritional knowledge of young athletes in Indonesia. Methods: This study is a pre-and post-experimental study without control. One hundred eighty-five young athletes who trained in PPLP and SKO received nutrition intervention for two months, including three nutrition education sessions using sports nutrition module media, nutritional counseling, and eating assistance based on eating etiquette. A modified Abridged Nutrition for Sport Knowledge Questionnaire (ANSKQ) questionnaire assessed athletes' nutritional knowledge before and after the intervention. Data was examined by comparing scores before and after the intervention. The Kolmogorov-Smirnov test was used in the normality test, and a paired t-test was used to compare nutritional knowledge before and after the intervention. Results: Before the intervention, 88.65% had a low level of knowledge about nutrition. The scores for sports nutrition and overall nutritional knowledge increased significantly (p<0.05). The scores of general nutrition knowledge increased but were not significant (p>0.05). Conclusions: There was a significant increase in sports nutrition knowledge but not general nutrition knowledge. The provision of nutritional education assisted by nutritionists impacts athletes' nutritional knowledge.