bluuebunny/crossref_metadata_2025 huggingface dataset:
PENERAPAN MODEL PROBLEM BASED LEARNING DALAM PEMBELAJARAN PENDIDIKAN AGAMA HINDU DAN BUDI PEKERTI KELAS XI IPA DI SMA DHARMA PRAJA DENPASAR
Authors: Swandari Ni Kadek Ayu Gita , Arini Ni Wayan , Adi Armini Ida Ayu
Published: December 2023

Model pembelajaran problem based learning merupakan salah satu model pembelajaran inovatif yang dapat memberikan kondisi belajar aktif kepada peserta didik. Problem Based Learning adalah suatu model pembelajaran yang melibatkan peserta didik untuk mempelajari pengetahuan yang berhubungan dengan masalah dan sekaligus memiliki keterampilan untuk memecahkan masalah, dari pengalaman memecahkan masalah sendiri tanpa bantuan dari guru mengkibatkan peserta didik tersebut lebih paham maka dapat menciptakan lingkungan belajar sebagai suatu sistem sosial yang memiliki ciri proses demokrasi dan proses ilmiah. Penerapan model pembelajaran problem based learning pada pembelajaran pendididkan agama Hindu dan budi pekerti kelas XI IPA di SMA Dharma Praja Denpasar membawa suasana pembelajaran yang baru karena sangat disenangi oleh peserta didik di kelas tersebut karena pembelajaran terasa menyenangkan dengan adanya pemecahan kasus-kasus dengan dikaitkan dengan kehidupan nyata. Adapun hasil penelitian ini akan menunjukan bagaimana penerapan model pembelajaran problem based learning dalam pendidikan agama Hindu dan budi pekerti kelas XI IPA di SMA Dharma Praja denpasar, dengan melalui pada tahap perencanaan, tahap pelaksanaan, dan tahap evaluasi serta kendala dan upaya yang dilakukan dan implikasi yang terjadi.
PENERAPAN MODEL PEMBELAJARAN KONTEKSTUAL DALAM MATA PELAJARAN PENDIDIKAN AGAMA HINDU DAN BUDI PEKERTI PADA SISWA KELAS XI DI SMA NEGERI 7 DENPASAR
Authors: Riskayanti Ni Luh Putu , Karsana I Nengah , Garbha Putra I Gede
Published: December 2023

Pembelajaran Pendidikan Agama Hindu dan Budi Pekerti yang memiliki kecenderungan hanya mengarah pada upaya menghafal dan tidak didasarkan pada pengalaman, dapat menyebabkan pengetahuan yang diperoleh akan mudah hilang dari ingatan siswa. Sehingga siswa akan pintar secara teoritis tanpa adanya aplikasi dan praktek dalam kehidupan. Tujuan penelitian ini adalah untuk mengidentifikasi bentuk model pembelajaran kontekstual, faktor pendukung dan penghambatnya, serta implikasi bagi siswa dan guru. Teori yang digunakan adalah: (1) Teori Konstruktivisme dari Jean Piaget dan Lev Vygotsky, (2) Teori Humanisme dari Abraham Maslow, dan (3) Teori Stimulus Respons dari Edward Lee Thorndike. Jenis penelitian ini adalah kualitatif dengan pendekatan fenomenologi. Pengumpulan data menggunakan teknik atau metode observasi, wawancara, dokumentasi, dan kepustakaan. Hasil penelitian menunjukkan (1) Terdapat 3 bentuk model kontekstual yaitu, tahap perencanaan, tahap pelaksanaan, tahap evaluatif. (2) Faktor pendukung: antusias siswa dalam belajar, fasilitas yang memadai, guru yang menguasai materi. Faktor penghambat: persiapan guru kurang matang, siswa tidak tertarik mengikuti pelajaran, kurangnya media pembelajaran. (3) Implikasi bagi siswa: menumbuhkan karakter siswa, mampu memahami materi pelajaran dan mampu mengimplementasikannya di kehidupan sehari-hari, meningkatkan kemampuan berpikir kritis dan kreatif. Implikasi bagi Guru Pendidikan Agama Hindu adalah mampu memberikan materi pelajaran yang bermakna karena adanya proses pengaitan materi terhadap kehidupan siswa.
PENERAPAN AJARAN TRI PARARTHA DALAM MENINGKATKAN PENGUATAN PENDIDIKAN KARAKTER SISWA KELAS VII DI SMP NEGERI 1 BANGLI
Authors: Julistyawan I Komang , Karsana I Nengah , Arimbawa I Nengah
Published: December 2023

Pendidikan karakter merupakan aspek yang penting dalam pembentukan pribadi yang baik khususnya pada siswa di SMP Negeri1 Bangli. dengan demikian, salah satu ajaran yang di gunakan dalam meningkatkan penguatan pendidikan karakter pada siswa yaitu ajaran Tri Parartha. Tri Parartha merupakan tiga konsep kebahagian yaitu asih, punia dan bhakti ketiga konsep ini akan membantu siswa dalam menguatkan pendidikan karakter pada siswa.
Rumusan masalah yang di bahas dalam penelitian ini yaitu sebagai berikut: (1) Bagaimanakah penerapan ajaran Tri Parartha dalam meningkatkan penguatan pendidikan karakter siswa kelas VII Di SMP Negeri1 Bangli ? (2) Apa saja kendala dan upaya yang di lakukan dalam menerapkan ajaran Tri Parartha dalam meningkatkan penguatan pendidikan karakter siswa kelas VII Di SMP Negeri1 Bangli ? (3) Bagaimanakah implikasi penerapan ajaran Tri Parartha dalam meningkatkan penguatan pendidikan karakter siswa kelas VII Di SMP Negeri1 Bangli ?.
            Hasil yang di peroleh dalam penelitian ini yaitu : (1) bentuk penerapan ajaran Tri Parartha yaitu bentuk penerapan asih contohnya peduli sesama, dan peduli lingkungan, punia yaitu dengan contohnya saling berbagi, dan bentuk penerapan bhakti contohnya mengucapkan sapa dan salam, dan melakukan persembahyangan bersama. (2) kendala dalam penerapan ajaran Tri Parartha berasal dari dua faktor, yaitu faktor dari dalam (internal) dan faktor dari luar ( eksternal ). Upaya yang di lakukan untuk mengatasi kendala tersebut yaitu dengan meningkatkan peran guru dan meningkatkan peran orang tua. (3) implikasi yang di timbulkan dalam penerapan ajaran Tri Paratha yaitu : implikasi pada karakter religius, karakter nasionalis, karakter gotong royong, karakter intgritas, dan karakter mandiri.
PENERAPAN KURIKULUM MERDEKA BELAJAR DALAM MENGEMBANGKAN MINAT BELAJAR PENDIDIKAN AGAMA HINDU DAN BUDI PEKERTI SISWA KELAS X SMA NEGERI 1 PUPUAN
Authors: Maheswara Rupa , Budiasih Ni Wayan , Muliani Ni Made
Published: December 2023

Tujuan pendidikan nasional salah satunya adalah kurikulum. SMA Negeri 1 Pupuan telah menerapkan kebijakan Kurikulum Merdeka Belajar, perlu dikaji dalam penelitian agar dapat dipahami bagi guru Agama Hindu dan Budi Pekerti di sekolah-sekolah lain. Adapun masalah yang akan dibahas antara lain (1) Bagaimanakah bentuk Kurikulum Merdeka Belajar dalam mengembangkan minat belajar Pendidikan Agama Hindu dan Budi Pekerti siswa kelas X SMA Negeri 1 Pupuan, (2) Apa saja kendala yang dihadapi dalam upaya yang dilakukan untuk mengatsi kendala penerapan Kurikulum Merdeka Belajar dalam mengembangkan minat belajar Pendidikan Agama Hindu dan Budi Pekerti siswa kelas X SMA Negeri 1 Pupuan, dan (3) Apa saja dampak penerapan Kurikulum Merdeka Belajar dalam mengembangkan minat belajar Pendidikan Agama Hindu dan Budi pekerti siswa kelas X SMA Negeri 1 Pupuan. Teori yang digunakan untuk menganalisis masalah adalah: Teori-teori Humanistik, dari Arthur Combs (1912-1999), Teori Konstruktivistik dari Lorsbach dan Tubin (1992). subjek penelitian ini adalah kepala sekolah, guru Agama Hindu dan siswa Agama Hindu kelas X SMA Negeri 1 Pupuan, Metode pengumpulan data adalah observasi non participant ,wawancara semi terstruktur, studi kepustakaan dan dokumentasi. Data yang telah terkumpul dianalisis dengan metode analisis deskriptif kualitatif dengan langkah langkah reduksi, penyajian data, dan penarikan simpulan. Hasil penelitian menunjukkan bahwa penerapan kurikulum merdeka belajar dalam mengembangkan minat belajar Pendidik Agama hindu dan budi pekerti kelas X di SMA Negeri 1 Pupuan dapat meningkatkan minat belajar peserta didik dilihat sudah ada peningkatan dalam keberanian peserta didik dalam mengemukakan ide atau gagasan mengenai materi pembelajaran khususnya Pendidikan Agama Hindu dan Budi Pekerti.
STRATEGI PEMBELAJARAN GURU PENDIDIKAN AGAMA HINDU SEBAGAI UPAYA PEMBENTUKAN PERILAKU GURUBHAKTI PESERTA DIDIK DI KELAS XI IPA DAN IPS SEKOLAH MENENGAH ATAS SARASWATI 1 DENPASAR
Authors: Yanti Ni Made Satya Novita , Nanduq Ferdinandus , Sukma Muniksu I Made
Published: December 2023

Strategi pembelajaran dalam pembelajaran Pendidikan Agama Hindu dan Budi Pekerti sangat penting untuk dapat meminimalisir perilaku menyimpang peserta didik. Sehingga dengan adanya strategi pembelajaran perilaku anak dapat terbentuk melalui ajaran agama Hindu. Menerapkan ajaran agama pada kehidupan sehari-hari akan menumbuhkan perilaku yang baik. Adapun masalah yang akan dibahas antara lain (1) Bagaimanakah realitas penerapan strategi pembelajaran guru pendidikan agama Hindu sebagai upaya pembentukan perilaku gurubhakti peserta didik di kelas XI IPA dan IPS Sekolah Menengah Atas Saraswati 1 Denpasar, (2) Bagaimanakah kelemahan strategi pembelajaran Guru pendidikan agama Hindu sebagai upaya pembentukan perilaku gurubhakti peserta didik di kelas XI IPA dan IPS Sekolah Menengah Atas Saraswati 1 Denpasar, (3) Bagaimanakah upaya mengoptimalkan strategi pembelajaran Guru pendidikan agama Hindu dalam pembentukan perilaku gurubhakti peserta didik di kelas XI IPA dan IPS Sekolah Menengah Atas Saraswati 1 Denpasar. Hasil penelitian menunjukkan Strategi pembelajaran yang digunakan Guru Pendidikan Agama Hindu sebagai upaya membentuk perilaku gurubhakti menggunakan pengembangan ajaran agama Hindu menggunakan strategi Discovery Learning. Strategi ini membuat peserta didik aktif dalam mencari pengetahuan. Guru dalam meningkatkan perilaku Gurubhakti peserta didik mengaitkan materi pembelajaran dengan kehidupan sehari-hari. Kelemahan dan upaya mengoptimalkan Strategi pembelajaran guru endidikan agama Hindu sebagai upaya pembentukan perilaku gurubhakti peserta didik dapat dibagi menjadi beberapa faktor yaitu: strategi pemilihan metode pembelajaran, strategi pemilihan pengembangan materi pembelajaran, strategi pemilihan media pembelajaran, strategi pengembangan pengelolaan kelas, dan strategi pemilihan evaluasi.
Kata kunci : strategi pembelajaran, Agama Hindu, Perilaku Gurubhakti, Peserta Didik, SMA Saraswati 1 Denpasar
The Sixth Interdisciplinary Biogeographic Expedition of the St. Petersburg Association of Scientists & Scholars to the Western Himalaya, Himachal Pradesh, India (October 2022)
Authors:   Zoological Institute, Russian Academy of Sciences, Saint Petersburg, Russian Federation, Borkin Leo J.
Published: December 2023

A biogeographic expedition to the state of Himachal Pradesh (India) in October 2022 is briefl y described. It was organized by the Center for Himalayan Research of the St. Petersburg Association of Scientists & Scholars (SPASS) and also took place under the auspices of the Russian Association of Researchers of the Himalaya and Tibet. In a row, this was the 6th interdisciplinary SPASS expedition to the Western Himalaya and the 4th SPASS expedition to Himachal Pradesh. Participants explored the central and eastern parts of this state. Particular interest was shown in the transition zone from the Indus basin (Sutlej River and tributaries) to the Ganges basin (Tons River and tributaries). Observations were made in the fi eld of botany, zoology (herpetology, ornithology, entomology) and veterinary science. Attention was paid to the distribution of Oriental and Palearctic species of plants and animals, plant communities of various types. The vertical zonation from subtropical forest to the cold high-mountain desert near Tibet was studied.
Novas tecnologias da informação e comunicação: um desafio para o processo ensino-aprendizagem
Authors: Baptista Suelen Suzy Gomes , Vale Rafaela Larissa Tavares do , Silva Felipe Pereira da , Barros Ediléia de Jesus Sousa , Mesquita Maria Julia Moreno , Shapiama Cindy Zayda Batista , Viana Fabiane de Souza Tapajos , Auzier Evilly Queiroz , Garcia Áurea Amazonas Monteiro , Passos Alexsanderson de Souza
Published: December 2023

Objetivo: Apontar as vantagens de utilizar as Novas Tecnologias da Informação e Comunicação (NTIC) no processo ensino-aprendizagem a distância, bem como na educação presencial. Revisão bibliográfica: A inserção das TIC no processo de ensino e aprendizagem vem melhorando significativamente, pois com elas pôde-se perceber que para aprender não é necessário estar em um lugar e horário específico, mas sim um guia de aprendizado que desperte interesse e motivação, sendo assim, o professor é um mediador, mentor e facilitador, que não apenas ensina conteúdo, mas sim o profissional que busca intermediar o acesso do aluno ao conhecimento, por meio do constante aprimoramento de sua metodologia de ensinar, criando com ajuda das TIC alternativas inovadoras, sem a necessidade de um processo formal e deliberado de ensino. Considerações finais: Com as aulas remotas, o processo de avaliação realizado pelo professor também passa por mudanças necessárias, mas que trazem progresso positivo, pois apesar de a prova já não ser o principal método para avaliar o aprendizado, a avaliação dinâmica e ativa coloca o aluno como principal responsável pelo seu aprendizado, e lhe proporciona conhecimento, garantindo o real sentido do processo de avaliar.
Chitosan/PEG-mediated spinal cord fusion after complete dorsal transection in rabbits – functional results at 30 days
Authors: Lebenstein-Gumovski Michael , Rasueva Tanzila , Zharchenko Alexander , Bashahanov Robert , Kovalev Dmitry A. , Zhirov Andrey , Shatokhin Anton , Grin Andrey
Published: December 2023

Background:

The aim was to study functional recovery in experimental animals (rabbits) with transected spinal cords treated with a combination of photo-cross-linked chitosan in a homogeneous mixture with polyethylene glycol (PEG-chitosan).

Methods:

20 rabbits (n = 10 experimental and n = 10 controls) were submitted to complete spinal cord transection at T9. The experimental group received an intraoperative injection of PEG-chitosan. Neurological recovery was assessed using the modified Basso, Beattie, and Bresnahan scale.

Results:

In the experimental group, partial recovery of movements, sensory function, and sphincter control were all observed by postoperative day 30. Paraplegia and anesthesia persisted in the control group; 4 controls died versus none in the test group.

Conclusion:

PEG-chitosan is a candidate for neurological restoration after spinal paralysis.
Scleral lenses application for the correction of postkeratoplastic ametropia
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation, Sinitsyn M.V. , Pozdeeva N.A. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation, Bodrova S.G. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation, Shlenskaya O.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation, Tikhonova O.I. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation, Terenteva A.E. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary Branch, Cheboksary, Russian Federation
Published: December 2023

Purpose. Analysis of clinical and functional results of correction of postkeratoplastic ametropia with rigid gas-permeable scleral lenses. Material and methods. Clinical and functional results of the correction of postkeratoplastic ametropia (PA) with rigid gas-permeable scleral lenses (RGSL) were analyzed based on a comprehensive examination of 25 eyes (25 patients). Of these, there were 16 men and 9 women. The mean age of the patients was 40±9 years. Uncorrected visual acuity (UCVA) was 0.14±0.16, best corrected visual acuity (BCVA) with glasses was 0.44±0.25, the spherical refractive component was 1.37±2.58 D, the cylindrical refractive component was –4,75±1.68 D. The follow-up period was about 5 years. Results. After application of RGSL, all patients noted a significant improvement in visual acuity due to the correction of PA and an increase in the regularity of the corneal graft. There was a statistically significant increase in BCVA in RGSL up to 0.66±0.13 (p=0.0022), which remained stable throughout the entire observation period. BCVA in RGSL 0.5 and above was noted in 93% of the eyes. In all patients, after the selection of RGSL, a significant decrease in total corneal aberrations, including higher order ones, was noted. When calculating the cell density of the epithelium of the corneal graft on HRT III Cornea after 5 years of wearing RGSL, a decrease in the cell density of all layers of the epithelium was noted. The absence of endothelial cell density loss, clinically significant corneal graft edema, and reduction in the biomechanical properties of the corneal graft indicate the safety of long-term use of RGSL in patients after keratoplasty. Conclusion. Clinical and functional analysis of the correction of postkeratoplastic ametropia with rigid gas-permeable scleral lenses during 5 years of observation showed: higher rates of best corrected visual acuity compared to spectacle correction by an average of 0.22±0.05, a significant decrease in corneal aberrations, a decrease in the density of cells of all corneal graft epithelium layers, high optical efficiency, and safety of their use during the entire observation period. Key words: postkeratoplastic ametropia, rigid gas-permeable scleral lens, corneal graft
Selective laser trabeculoplasty (SLT) after glaucoma surgery in moderate and advanced primary open-angle glaucoma
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Brunch, St. Petersburg, Russian Federation, Suetov A.A. ,   State Scientific Research Test Institute of Military Medicine, St. Petersburg, Russian Federation, Doktorova T.A. ,   S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Brunch, St. Petersburg, Russian Federation,   I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation, Molodkina N.A. ,   S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Brunch, St. Petersburg, Russian Federation
Published: December 2023

Purpose. To study the hypotensive effect of selective laser trabeculoplasty (SLT) treatment in cases of insufficient effectiveness or reduced hypotensive effect of glaucoma surgery in patients with moderate and advanced primary open-angle glaucoma (POAG). Material and methods. A retrospective study was conducted of 32 patients (32 eyes) with POAG after previous glaucoma surgery and uncompensated intraocular pressure (IOP), who underwent SLT due to the impossibility of reoperation. Changes in IOP were studied 1 day, 1, 3, 6 and 12 months after SLT. Results. After SLT, the IOP level decreased from 24.5±4.4 to 19.3±3.8 mm Hg after 1 day (p<0.001), the hypotensive effect was 5.2±5.1 mm Hg (21.2% of the baseline IOP) and did not change significantly within 3 months after laser treatment. After 6 and 12 months, a decrease in the hypotensive effect was revealed compared with the primary response 1 day after SLT (3.0±2.9 and 1.9±5.4 mm Hg, p=0.02). 12 months after SLT, the IOP level remained below the baseline IOP only in 46.9% of cases. There were no significant differences in the results of SLT at different stages of POAG, different types of glaucoma surgery, different medication regimens (p>0.05), and there was no dependence on the timing after previous glaucoma surgery. Conclusion. SLT can be used after previous glaucoma surgery when IOP reduction is insufficient in patients with moderate and advanced POAG. However, the hypotensive effect of SLT in such cases is unstable, so this method of treatment should be considered only as an auxiliary one and if repeated surgery is not possible, as well as providing more frequent control of IOP in patients. Key words: glaucoma, selective laser trabeculoplasty, intraocular pressure, glaucoma surgery, ophthalmic surgery
Proton therapy for uveal melanoma (preliminary results)
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Branch, St. Petersburg, Russian Federation, Panova I.E. , Vorobiov N.A. ,   Medical and Diagnostic Center of S. Berezin International Institute of Biological Systems, St. Petersburg, Russian Federation,   Saint Petersburg State University, St. Petersburg, Russian Federation, Samkovich E.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Branch, St. Petersburg, Russian Federation, Bykhovskii A.A. ,   S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Branch, St. Petersburg, Russian Federation, Martynova N.I. ,   Medical and Diagnostic Center of S. Berezin International Institute of Biological Systems, St. Petersburg, Russian Federation, Svistunova E.M. ,   I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation
Published: December 2023

Purpose. To present preliminary results of treatment of uveal melanoma with proton therapy using the scanning pencil beam technique. Material and methods. In this study we included 7 patients (female) with uveal melanoma aged 23 to 51 years. The tumor was localized in the choroid (4), ciliochoroidal (2) and iridociliary (1) zones. All patients received proton therapy in the hypofractionation mode at a total dose of 49 Gy in 7 fractions (BED0,6=620 Gy; EQD2=143 Gy). The follow-up period for patients ranged from 6 to 33 months. Results. In the early post-radiation period, a radiation reaction was observed in the form of skin erythema (2 patients), exudative retinal detachment (3 patients). Late complications were observed as neovascular glaucoma, which developed 6–11 months after the start of treatment in 4 patients, maculopathy (1 patient), dry eye syndrome with madarosis (3 patients). All treated patients had a slow rate of tumor regression, as a rule, the tumor began to regress after 6–8 months from the start of treatment. Complete regression was observed in 2 patients with T3aN0M0 stages of the process for a period of 24 months, the rest showed partial regression of the tumor. Conclusion. The obtained preliminary results of proton therapy using the scanning pencil beam technique are very encouraging in the treatment of large uveal melanomas and open a new perspective in their successful treatment. The use of photodynamic therapy with chlorin drugs should probably be considered as an adjuvant therapy, the effect of which will accelerate the rate of regression and reduce the incidence of complications. Key words: choroidal melanoma, proton therapy, brachytherapy, uveal melanoma, ophthalmo-oncology, choroidal melanoma treatment
Attracting investments in the Arctic: in which regions are Arctic residents the most significant, effective and sustainable?
Authors:   Institute of Economics of the Karelian Research Centre of the Russian Academy of Sciences, Karginova-Gubinova V.V. , Vasilieva A.V. ,   Institute of Economics of the Karelian Research Centre of the Russian Academy of Sciences, Moroshkina M.V. ,   Institute of Economics of the Karelian Research Centre of the Russian Academy of Sciences, Potasheva O.V. ,   Institute of Economics of the Karelian Research Centre of the Russian Academy of Sciences
Published: December 2023

The high geopolitical and strategic importance of the regions of the Arctic zone of the Russian Federation, on the one hand, and the presence of climatic, socioeconomic and infrastructural limitations on their development on the other, determine the need to use special economic institutions for the Arctic territories. And one of them is the institution of Arctic residents, which involves the creation of preferential treatment and attraction of new investors to the Arctic. The purpose of the article is to assess the effectiveness of the Arctic residents’ institution as a tool for the development of the Arctic territories and the reduction of their polarization. The study assesses the investment attractiveness of the regions of the Arctic zone of the Russian Federation using econometric methods and cluster analysis, taking into account statistical indicators and expert assessments in five areas for 2010—2021. Also, using similar methods and according to financial statements the authors analyze the economic efficiency and sustainability of 295 economic entities that received the status of Arctic resident in 2020—2021. The level of investment attractiveness of the regions they compare with the efficiency and sustainability of the residents functioning on its territory. They have revealed that the institution of Arctic residents, although contributing to the development of the Arctic regions, leads to further polarization of their indicators. The theoretical significance of the work lies in the formation of the authors’ methodology for ranking the Arctic regions and residents. The recommendations elaborated within the framework of the work are of practical importance for the further development of the Arctic.
Probability analysis of metamorphization of the ionic composition of ultra-fresh waters of the Arctic rivers of Russia
Authors:   Hydrochemical Institute, Reshetnyak O.S.
Published: December 2023

For the first time, the classification of the ionic composition of ultra-fresh waters of the Arctic rivers in Russia has been carried out in a long-term aspect and in view of seasonality. The features of the ionic composition of ultra-fresh waters of the Arctic rivers have been considered, the class, group and type of river waters have been established according to the classification of O. A. Alekin. The chemical composition of the ultra-fresh rivers of the Russian Arctic zone is characterized by great diversity. These rivers vary from the most simple bicarbonate-calcium waters of the second type to sulfate or hydrocarbon-sulfate waters of a complex cationic composition. For the estuarine sections of the Virma, Kolos-Yoki, Teriberka and Ura Rivers variability manifests itself in a simplification of the chemical composition. For the Pravaya Khetta, Sede-Yakha and Nadym Rivers, changes in the ratios between cations and anions have been revealed. For the Indigirka, Yana Rivers and its tributaries, changes have been noted only in the anionic composition. It is shown that it is for these rivers that the metamorphization of river waters is possible. Most of the river sections with a high probability of metamorphization of the ionic composition of water are confined to the West Siberian part of the Russian Arctic zone. This is due to a higher anthropogenic load and a high degree of development of this area. For these sections of the rivers, the revealed metamorphization is of a technogenic nature. The metamorphization process of ultra-fresh river waters in the direction of changing the hydrocarbonate class to the sulfate or chloride class can cause the appearance of hydrochemical anomalies in the content of the main ions.
Environmental aspects of industrial development of oil and gas fields in the Arctic territories of the Komi Republic
Authors:   Yushkin Institute of Geology, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences, Timonina N.N. , Kuznetsov D.S. ,   Yushkin Institute of Geology, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences, Kuznetsov S.K. ,   Yushkin Institute of Geology, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences
Published: December 2023

The paper considers the ecological aspects of the development of oil and gas fields in the Arctic zone of the Komi Republic. The authors inform about the state of the resource base, the dynamics of oil production, drilling of wells, and the increase in reserves. Oil and gas production dominates in the region’s economy, while at the same time impacts negatively on the environment. Field development, geological exploration, drilling of exploration and production wells, laying of pipelines, transportation of oil and other types of work are inevitably accompanied by harmful emissions into the atmosphere, pollution of water bodies and the earth surface. There is a thermal, mechanical and chemical impact on the environment. The situation is getting worse due to the increase in the share of hard-to-recover dense and high-viscosity oil in recoverable oil reserves. The development of hard-to-recover oil deposits is carried out via technologies that cause additional environmental damage. A large amount of oil enters the environment not during its extraction, but due to accidents at oil pipelines, especially inter-field and intra-field ones. The Arctic regions are ecologically very vulnerable due to the spread of permafrost. The technogenic thermal impact activates various negative processes, such as subsidence, swelling, erosion, landslides, flooding, waterlogging. Among the most polluted Arctic regions where oil production is carried out, is the Usinsky region with a number of large oil fields being developed, and extensive network of oil pipelines laid. The authors suggest a number of measures to minimize the negative impact on the environment during the construction and operation of oil production facilities. They outline the need to comply with the equipment technological operating modes, carry out preventive measures, including control of the technical condition of the basic equipment, to analyze the transported products (physical and chemical properties of the working environment), as well as to implement measures for the protection of surface and ground waters. It is expedient to upgrade the pipeline infrastructure in a timely manner with the use of the latest achievements in the field of pipe surface protection, and the elimination of decommissioned boreholes.
Features of the spatial distribution of 137Cs, 40K, 226Ra, 232Th in the soils of the city of Kirovsk (Murmansk region)
Authors:   N. Laverov Federal Center for Integrated Arctic Research, Iglovsky S.A. , Bazhenov A.V. ,   N. Laverov Federal Center for Integrated Arctic Research, Kriauciunas V.V. ,   N. Laverov Federal Center for Integrated Arctic Research, Yakovlev E.Y. ,   N. Laverov Federal Center for Integrated Arctic Research
Published: December 2023

The article presents the results of a study of soils in the city of Kirovsk. The purpose of the work is to establish the main regularities of the spatial distribution of natural and technogenic radionuclides in the urban soils of Kirovsk. To achieve this goal, soil samples were taken in all parts of the city. The following methods were used in the course of expeditionary work and laboratory research: soil, radiological, mathematical and statistical. The values of specific activity in samples of urban soils were: for technogenic 137Cs (from 3 to 48.3 Bq/kg), for natural radionuclides: 226Ra (from 11.8 to 44.2 Bq/kg), 232Th (from 9.8 to 34.8 Bq/kg), 40K (from 232.2 to 2086 Bq/kg). The values of the effective specific activity of natural radionuclides in urban soil samples ranged from 47 to 277 Bq/kg and 137Cs from 3.2 to 48.3 Bq/kg.
МИКРО-РНК КАК ПОТЕНЦИАЛЬНЫЕ НЕИНВАЗИВНЫЕ МАРКЕРЫ ПАТОЛОГИЧЕСКИХ СОСТОЯНИЙ ПЕЧЕНИ
Authors:   Grodno State Medical University, Grodno, Belarus, Andreev V. P. , Tsyrkunov V. M. ,   Grodno State Medical University, Grodno, Belarus
Published: December 2023

The state of the cell (and the organism as a whole) is determined not only by the genotype, but by the ratio of turned on and off genes as well. Epigenetic regulation of gene expression plays a key role in the control of many cellular processes. Being important molecules of such regulation microRNAs are involved in post-transcriptional turning about half of human genes off. Abnormal expression of microRNAs, leading to changes in their concentration, can contribute to the development of many pathophysiological processes, diseases as well as cancer, and therefore microRNAs can be regarded as biomarkers for identifying various types of diseases. This mini-review presents the biogenesis, subcellular and exosomal localization of microRNAs and the mechanisms by which they regulate transcription and cellular homeostasis.
СПОСОБЫ ЗАКРЫТИЯ ПЕРФОРАТИВНОГО ОТВЕРСТИЯ ЯЗВ ЖЕЛУДКА И ДВЕНАДЦАТИПЕРСТНОЙ КИШКИ
Authors:   City Clinical Emergency Hospital of Grodno, Grodno, Belarus, Makarevich E. I. , Kudlo V. V. ,   Grodno State Medical University, Grodno, Belarus, Zhuk I. G. ,   Grodno State Medical University, Grodno, Belarus
Published: December 2023

This literature-based review analyzes different methods of closure of perforated gastric and duodenal ulcers. In addition, there have been determined the indications for the use of each method, the technique of performing, the advantages and disadvantages, as well as the prospects for use and their feasibility at the current level of abdominal surgery development.
Semiotika Umberto Eco Dalam Representasi Perempuan Film Animasi Disney Raya and the Last Dragon
Authors: Fadhilla Annisa Nurul , Ismandianto ismandianto
Published: December 2023

Film merupakan salah satu bentuk komunikasi massa yang paling cukup berkembang dan dinamis, dengan menggunakan berbagai perangkat teknologi canggih yang mampu menciptakan film animasi. film tidak hanya digunakan sebagai media hiburan dan kesenangan semata, namun juga dapat digunakan untuk menggambarkan realitas yang terjadi di dunia nyata, termasuk dalam cara menggambarkan perempuan. Film Animasi Disney Raya and the Last Dragon menggambarkan perempuan sebagai sosok yang mandiri, tangguh, dan mampu berjuang tanpa didampingi laki-laki, dan berbeda dengan penggambaran perempuan pada umumnya. Penelitian ini bertujuan untuk mengetahui bagaimana representasi perempuan yang terdapat dalam Film Animasi Disney Raya and the Last Dragon. Penelitian ini merupakan penelitian kualitatif dengan menggunakan analisis semiotika umberto eco, dan kategori feminim dan maskulin menurut BSRI. Hasil penelitian menunjukkan bahwa reperesentasi perempuan dalam film ini terdapat pada penampilan, ekspresi, dialog, gerak tubuh, dan sikap, yang menunjukkan karakter Raya dan Namaari yang tangguh, cerdas, dan mampu memimpin serta membuat keputusan. Dan Berdasarkan kategori feminin dan maskulin menurut BSRI, berbagai karakter yang ditemukan dalam film ini yaitu karakter maskulin seperti mampu memimpin, suka bersaing, mandiri,  dan berani mengambil risiko, sedangkan karakter feminim ditunjukkan pada karakter yang penyayang, simpati, dan penurut.
The impact of the nutrient ratio in a diet on the rabbit hematology of the “Rodnik” cross
Authors: Квартникова Е.Г. , Петрова И.В. , Косовский Г.Ю. , Кровина Е.В.
Published: December 2023

Исследования проведены в отделе звероводства и кролиководства и виварии ФГБНУ «Научно-исследовательский институт пушного звероводства и кролиководства им. В. А. Афанасьева» (Московская обл., Раменский р-н, г.п. Родники) в 2023 году. В серии физиологических опытов были изучены и проанализированы морфологические и биохимические показатели кроликов кросса «Родник» в 45- и 77-суточном возрасте (убой на мясо). Цель работы — определить влияние соотношения питательных веществ в полнорационном гранулированном комбикорме на морфологические и биохимические показатели крови молодняка кроликов кросса «Родник». Из 12 кроликов по принципу аналогов по происхождению, возрасту, живой массе было сформировано три группы — одна контрольная и две опытные. Содержали кроликов по одной голове в специально оборудованных клетках. Кролики каждой группы получали свой комбикорм, отличающийся от комбикорма других групп по составу, соотношению питательных веществ и энергии. Забор крови производили из ушной вены, исследования крови проводили на современных автоматических анализаторах. Установлены морфологические и биохимические показатели сыворотки крови кроликов кросса «Родник». Содержание в крови кроликов билирубина (общего — меньше 2,0 ммоль/л и прямого — меньше 1,0 ммоль/л) свидетельствует об адекватном содержании клетчатки в рационе. Уровень общего белка в сыворотке крови кроликов кросса «Родник» не зависел от его содержания в полнорационном комбикорме, но был ниже, чем у помесных кроликов, на 22,9%, а уровень глюкозы, отражающий интенсивность углеводного обмена, был выше в среднем на 1,5 ммоль/л. У клинически здоровых кроликов кросса «Родник» коэффициент де Ритиса больше 1.

This investigation was conducted at the Research Institute of Fur Farming and Cuniculture n. a. V. A. Afanasev in 2023. The experiment tested the morphology and blood biochemistry of 45- and 77-day-old rabbits of the “Rodnik” cross (for meet production). The aim of this research was to indentify the impact of the nutrient ratio in a complete granulated feed (CGF) on the morphology and blood biochemistry of young rabbits of the “Rodnik” cross. Two test-groups and one control group were formed from 12 rabbits according to their origin, age, and weight. Each rabbit was kept in a specifically equipped cage. Each group obtained feeds with different nutrient composition, ratio and energy content. Blood was taken from the ear vein and tested using modern automatic analyzers. The content of blood bilirubin (total — under 2.0 mmol/l and the direct one — under 1.0 mmol/l) indicated an adequate fiber content in the diet. The protein content in the diet affected the protein in the blood serum of the “Rodnik” cross insignificantly. But the crossbred rabbits exceeded the “Rodnik” cross in the serum protein by 22.9%. However, the “Rodnik” cross showed higher glucose level (by 1.5 mmol/l), reflecting the intensity of carbohydrate metabolism. Healthy rabbits of the “Rodnik” cross had the AST/ALT ratio of over 1.
Overview of the Bearing Capacity Finned Concrete Slabs Based on Slope of the Fins Using Numerical Method
Authors: Mandagi Nashril Ananta , Yusuf Muhammad , Bachtiar Vivi
Published: December 2023

Indonesia is a country that has a land area of approximately 1.905 million km². Facilities and infrastructure are needed to support community mobility to balance the land area. One of the infrastructures needed to carry out this mobilization is roads. In building roads, it is necessary to pay attention to safety and comfort aspects so the community can optimally use these facilities. Experts have contributed much of their thoughts to create a road construction used today. Concrete Structure is a common structure used by experts for road construction in Indonesia. Concrete construction was chosen because it is easy to form and stiff so it is easy to adapt to regions in Indonesia. However, road damage still occurs frequently, so a more effective construction system is needed to reduce road damage. In the previous study (Sirait et al., 2022; Syenna et al., 2022), experimental research was carried out in the form of finned concrete slab construction which functions to increase the bearing capacity of the concrete slab. Variations on the tilt of the fins are used, namely 0°, 10°, 20°, 30°, and 40°. This study found that concrete slabs with a fin slope of 30° produced the greatest carrying capacity of the other sample models. This research is still reviewing the same aspect, namely finding the optimal fin slope on concrete slab samples with variations of fin slope of 0°, 10°, 20°, 30°, and 40°. However, the method used is a numerical method by making approximations to the original conditions of the samples. Simulating loading tests on cohesive soils and non-cohesive soils carried out samples. By this numerical method, it was found that concrete slabs with a fin slope of 10° had the highest bearing capacity of the other samples.
Investigation of the Electrocatalytic Reduction of Peroxydisulfate Using Scanning Electrochemical Microscopy
Authors: Hosseini Seyyedamirhossein , Solymosi Gergely , White Henry
Published: December 2023

The elementary steps of the electrocatalytic reduction of S2O82– using the Ru(NH3)63+/2+ redox couple were investigated using scanning electrochemical microscopy (SECM) and steady-state voltammetry (SSV). SECM investigations were carried out in a 0.1 M KCl solution using a 3.5-µm radius carbon ultramicroelectrode (UME) as the SECM tip and a 25-µm radius platinum UME as the substrate electrode. Approach curves were recorded in the positive feedback mode of SECM by reducing Ru(NH3)63+ at the tip electrode and oxidizing Ru(NH3)62+ at the substrate electrode, as a function of the tip-substrate separation and S2O82– concentration. The one-electron reaction between electrogenerated Ru(NH3)62+ and S2O82– yields the unstable S2O83•-, which rapidly dissociates to produce highly oxidizing SO4•–. Because SO4•– is such a strongly oxidizing species, it can be further reduced at both the tip or the substrate, or it can react with Ru(NH3)62+ to regenerate Ru(NH3)63+. SECM approach curves display a complex dependence on the tip-substrate distance, d, due to redox mediation reactions at both the tip and the substrate. Finite element method (FEM) simulations of both SECM approach curves and SSV confirm a previously proposed mechanism for the mediated reduction of S2O82– using Ru(NH3)63+/2+ redox couple. Our results provide a lower limit for dissociation rate constant of S2O83•– (~ 1 × 106 s–1), as well as the rate constants for electron transfer between SO4•– and Ru(NH3)62+ (~ 1 × 109 M–1s–1) and between S2O82– and Ru(NH3)62+ (~7 × 105 M–1s–1).
Tuning Potential Functions to Host–Guest Binding Data
Authors: Setiadi Jeffry , Boothroyd Simon , Slochower David , Dotson David , Thompson Matthew , Wagner Jeffrey , Wang Lee-Ping , Gilson Michael K.
Published: December 2023

Software to more rapidly and accurately predict protein--ligand binding affinities is of high interest for early-stage drug discovery, and physics-based methods are among the most widely used technologies for this purpose. The accuracy of these methods depends critically on the accuracy of the potential functions they use. Potential functions are typically trained against a combination of quantum chemical and experimental data. However, although binding affinities are among the most important quantities to predict, experimental binding affinities have not to date been integrated into the experimental dataset used to train potential functions. In recent years, the use of host--guest complexes as simple and tractable models of binding thermodynamics has gained popularity due to their small size and simplicity, relative to protein--ligand systems. Host--guest complexes can also avoid ambiguities that arise in protein--ligand systems, such as uncertain protonation states. Thus, experimental host--guest binding data are an appealing additional data type to integrate into the experimental dataset used to optimize potential functions. Here, we report the extension of the Open Force Field Evaluator framework to enable the systematic calculation of host--guest binding free energies and their gradients with respect to force field parameters, coupled with the curation of 126 host--guest complexes with available experimental binding free energies. As an initial application of this novel infrastructure, we optimized generalized Born (GB) cavity radii for the OBC2 GB implicit solvent model against experimental data for 36 host--guest systems. This refitting led to a dramatic improvement in accuracy for both the training set and a separate test set with 90 additional host--guest systems. The optimized radii also showed encouraging transferability from host--guest systems to 59 protein-ligand systems. However, the new radii are significantly smaller than the baseline radii and lead to excessively favorable hydration free energies (HFE). Thus, users of the OBC2 GB model currently may choose between GB cavity radii that yield more accurate binding affinities or GB cavity radii that yield more accurate HFEs. We suspect that achieving good accuracy on both will require more far-reaching adjustments to the GB model. We note that binding free energy calculations using the OBC2 model in OpenMM gain about a 10x speedup relative to corresponding explicit solvent calculations, suggesting a future role for implicit solvent absolute binding free energy (ABFE) calculations in virtual compound screening. This study proves the principle of using host--guest systems to train potential functions that are transferrable to protein--ligand systems, and provides an infrastructure that enables a range of applications.
Carboxylate catalyzed silylation of alkynes
Authors: Bannykh Anton , Pihko Petri
Published: December 2023

A carboxylate-catalyzed, metal-free C-silylation protocol for terminal alkynes is reported using a quaternary ammonium pivalate as the catalyst and commercially available N,O-bis(silyl)acetamides as silylating agents. The reaction proceeds under mild conditions, tolerates a range of functionalities, and enables concomitant O- or N-silylation of acidic OH or NH groups. A Hammett ρ value of +1.4±0.1 obtained for p-substituted 2-arylalkynes is consistent with the proposed catalytic cycle involving turnover-determining deprotonation step.
Catalyst-Free Late-Stage Functionalization to Assemble α-acyloxyenamide Electrophiles for Selectively Profiling Conserved Lysine Residues
Authors: Zhao Yuanyuan , Duan Kang , Fan Youlong , Li Shengrong , Huang Liyan , Tu Zhengchao , Yang Jing , Sun Pinghua , Tan Yi , Ding Ke , Li Zhengqiu
Published: December 2023

Covalent probes coupled with chemical proteomics represent a powerful method for investigating small molecule and protein interactions. However, the creation of a reactive warhead within various ligands to form covalent probes has been a major obstacle. Herein, we report a convenient and robust process to assemble a unique electrophile, an α-acyloxyenamide, through a one-step late-stage coupling reaction. This procedure demonstrates remarkable tolerance towards other functional groups and facilitates ligand-directed labeling in proteins of interest. The reactive group has been successfully incorporated into a clinical drug targeting the EGFR L858R mutant, erlotinib, and a pan-kinase inhibitor. The resulting probes have been shown to be able to covalently engage a lysine residue proximal to the ATP-binding pocket of the EGFR L858R mutant. A series of active sites, and Mg2+, ATP-binding sites of kinases, such as K33 of CDK1, CDK2, CDK5; K278 of PAK2 and K270 of KPYM were detected. This is the first report of engaging these conserved catalytic lysine residues in kinases with covalent inhibition. Further application of this methodology to natural products has demonstrated its success in profiling ligandable conserved lysine residues in whole proteome. These findings offer insights for the development of new targeted covalent inhibitors (TCIs) and pave the way for future advancements in drug discovery and chemical proteomics.
Closed-Loop Supply Chain Integration: Assessing Marketing Impacts and Customer Perceptions of Sustainable Brand Value in the Saudi Photovoltaic Industry
Authors: Soliman Karim , Bahareth Aseel
Published: December 2023

Purpose:  This investigation addresses the influence of closed-loop supply chain integration (CLSCI) on consumer perception of sustainable brand value, examining its effect on purchasing decisions, brand loyalty, and image.
 
Theoretical framework:  The study operates within a framework that posits CLSCI as a potential enhancer of sustainable brand value, mediated by demographic variables and consumer consciousness of sustainability practices.
 
Design/methodology/approach:  A cross-sectional analysis was performed with 240 Saudi participants using Multivariate Analysis of Variance (MANOVA) to assess the hypotheses derived from the theoretical framework.
 
Findings:  Results indicate a direct correlation between CLSCI and brand image, strengthened by consumer awareness. Moreover, age and awareness significantly mediate the relationship between CLSCI and perceived brand value and purchasing decisions.
 
Research, Practical & Social implications:  Findings underscore the necessity for Saudi photovoltaic (PV) firms to elevate CLSCI awareness and its linkage to brand image. The study also prompts further examination of age-related influences and sustainable waste management practices.
 
Originality/value:  his study contributes to the limited research on CLSCI's role within the Saudi PV sector, providing empirical evidence and a conceptual model for CLSCI implementation, offering insights for enhanced consumer engagement and sustainable brand development.