INTERACTION BETWEEN INFLAMMATION MARKERS AND ANXIETY-DEPRESSIVE DISORDERS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Authors:   Bashkir State Pedagogical University, SHAYAKHMETOVA ELVIRA SH. , MUTALOVA ELVIRA G ,   Bashkir State Medical University, GALYAUTDINOVA VELENA R. ,   Bashkir State Medical University, FRID SVETLANA A. ,   Bashkir State Medical University, MINGAZETDINOVA LIRA N. ,   Bashkir State Medical University, KAMALTDINOVA GULNARA J. ,   Bashkir State Medical University, ASADULLINA GULNARA V. ,   Bashkir State Medical University, RUSTYAMOVA ZULFIYA YA. ,   Bashkir State Medical University, NIGMATULLINA ALBINA E. ,   Bashkir State Medical University, SAMIGULLINA LIANA I. ,   Bashkir State Medical University, SADIKOVA REGINA I. ,   Bashkir State Medical University, MUSINA FLARISA S. ,   Bashkir State Medical University
Published: June 2024

Abstract. Introduction. In recent years, the influence of anxiety and depressive disorders on the course of cardiovascular diseases has been increasingly discussed. The main psychosocial risk factors for the development of acute myocardial infarction include depression and anxiety (various anxiety syndromes and disorders). Currently, inflammation is considered as one of the leading links in myocardial infarction pathogenesis, course, and prognosis. Recent studies have linked the development of anxiety and depressive disorders with changes in the proinflammatory cytokine levels. Severity of immunoinflammatory reactions in patients with unstable forms of coronary heart disease is greater than in patients with a stable course of the disease. The aim of our investigation was to study the proinflammatory cytokine levels in patients with myocardial infarction depending on the presence of anxiety and depressive disorders. Materials and Methods. The study included 160 patients, averagely aged 56.2±1.4 years, who were admitted to the hospital with the ST-segment elevation myocardial infarction. The diagnosis of the said disease was set according to the generally accepted diagnostic criteria. In addition to the traditional clinical and instrumental studies, the patients of the groups under study underwent an assessment of the concentrations of inflammatory biomarkers in plasma and psychological tests using anxiety and depression rating scales, such as Zung Depression Scale and Spielberger-Khanin Anxiety Scale. Results and Discussion. Signs of depression were identified in 82 (51.25%) patients with acute myocardial infarction. Symptoms of mild depression were identified in 44 (53.7%) patients, moderate depression in 30 (36.6%) patients, and severe depression in 8 (9.7%) patients. It has been proven that the average depression score increases with the increase in the disease severity. The average score was 49.72+1.68 for personal anxiety in the group and 41.9±1.6 for reactive anxiety. As the class of infarction severity increased, a significant increase in anxiety levels was observed. An increase in the serum concentrations of CRP, IL-1β, IL-6, IL-8, and TNF-α was detected during the development of myocardial infarction, which was statistically significantly associated with the presence of anxiety-depressive disorders and some indicators of myocardial contractile function. Conclusions. Subclinical inflammation is one of the mechanisms of the negative impact of anxiety and depressive disorders on the prognosis for this category of patients. The presence of anxiety and depression symptoms is associated with higher levels of pro-inflammatory markers, i. e., CRP, IL-1β, IL-6, IL-8, and TNF-a. The degree of activation of proinflammatory markers depends on the severity of the myocardial damage signs and on the nature of complications.