bluuebunny/crossref_metadata_2025 huggingface dataset:
Perceptions of the use of mobile applications to assess memory in older adults with subjective and objective cognitive impairment: A focus group approach (Preprint)
Authors: Lam Aaron , Simonetti Simone , D'Rozario Angela , Ireland David , Bradford Dana , Fripp Jurgen , Naismith Sharon L
Published: November 2024

BACKGROUND

Sleep-dependent memory is the phenomenon where newly obtained memory traces are consolidated from short-term memory stores to long-term memory, underpinning memory for daily life. Administering sleep-dependent memory tasks presents considerable challenges, particularly for older adults with memory concerns due to the need for sleep laboratories and research staff present to administer the task. In response, we have developed a prototype mobile application aimed at automating the data collection process.

OBJECTIVE

This study investigates the perspectives of older adults, both with and without cognitive impairment, regarding barriers and facilitators to using a new mobile application for at-home assessment of Sleep-Dependent Memory.

METHODS

Eleven participants aged over 50 were recruited from the Healthy Brain Ageing memory clinic, a specialised research memory clinic that focuses on the assessment and early intervention of cognitive decline. Two focus groups were conducted and thematically analysed using NVivo and the techniques described in Braun and Clarke (2006).

RESULTS

On average, participants were aged 68.5 (4/11 were male), eight participants had subjective cognitive impairment, and three participants had mild cognitive impairment. Two main themes emerged from the focus groups, shedding light on participants' use of mobile phones and the challenges and facilitators associated with transitioning from traditional laboratory-based assessments to home assessments. These challenges include maintaining accurate data, engaging with humans versus robots, and ensuring accessibility and task compliance. Additionally, potential solutions to these challenges were identified.

CONCLUSIONS

Our findings underscore the importance of app flexibility in accommodating diverse user needs and preferences, as well as in overcoming barriers. While some individuals require high-level assistance, others express the ability to navigate the app independently with minimal support. In conclusion, older adults, regardless of cognitive status, express a desire for flexibility in mobile applications used for cognitive assessments.
The Use of Mobile Health Care Among Medical Professionals in the Sichuan-Chongqing Region: Cross-Sectional Survey Study (Preprint)
Authors: Tang Shuhan
Published: November 2024

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/59153
Era of Generalist Conversational Artificial Intelligence to Support Public Health Communications (Preprint)
Authors: Sezgin Emre , Kocaballi Ahmet Baki
Published: November 2024

UNSTRUCTURED

The integration of artificial intelligence (AI) into health communication systems has introduced a transformative approach to public health management, particularly during public health emergencies, capable of reaching billions through familiar digital channels. This paper explores the utility and implications of generalist conversational artificial intelligence (CAI) advanced AI systems trained on extensive datasets to handle a wide range of conversational tasks across various domains with human-like responsiveness. The specific focus is on the application of generalist CAI within messaging services, emphasizing its potential to enhance public health communication. We highlight the evolution and current applications of AI-driven messaging services, including their ability to provide personalized, scalable, and accessible health interventions. Specifically, we discuss the integration of large language models and generative AI in mainstream messaging platforms, which potentially outperform traditional information retrieval systems in public health contexts. We report a critical examination of the advantages of generalist CAI in delivering health information, with a case of its operationalization during the COVID-19 pandemic and propose the strategic deployment of these technologies in collaboration with public health agencies. In addition, we address significant challenges and ethical considerations, such as AI biases, misinformation, privacy concerns, and the required regulatory oversight. We envision a future with leverages generalist CAI in messaging apps, proposing a multiagent approach to enhance the reliability and specificity of health communications. We hope this commentary initiates the necessary conversations and research toward building evaluation approaches, adaptive strategies, and robust legal and technical frameworks to fully realize the benefits of AI-enhanced communications in public health, aiming to ensure equitable and effective health outcomes across diverse populations.
LLM-Assisted Content Analysis (LACA) on Online Reviews for Hospital Quality Improvements Activities (Preprint)
Authors: Sulaiman Muhammad Hafiz , Muda Nora , Abdul Razak Fatimah
Published: November 2024

BACKGROUND

LLM-Assisted Content Analysis (LACA) is a modification of traditional content analysis, leveraging the Large Language Model (LLM) to co-develop codebooks and automatically assign thematic codes to online reviews dataset.

OBJECTIVE

This article is intended to explore and set a recommendation on how LACA can be applied on online reviews to address quality issues in hospitals.

METHODS

Online reviews for 53 private hospitals in Selangor Malaysia were acquired. Fake reviews were filtered out and a sample of 200 reviews was randomly extracted and fed into gpt-4o-mini model API to produce a codebook which was then used to code (label) all reviews in the dataset. Patterns of thematic codes across the whole dataset were presented using python matplotlib. The thematic codes were then summarized into themes using factor analysis to increase interpretability.

RESULTS

14,938 online reviews were acquired in which 1,279 comments were detected to mention quality issues. gpt-4o-mini model subsequently inducted 41 thematic codes together with their definitions. Average Human-GPT inter-rater reliability is perfect (kappa = 0.81). Factor analysis identified six interpretable latent factors: 'Service & Communication Effectiveness’, 'Clinical Care & Patient Experience’, ‘Facilities & Amenities Quality’, ‘Appointment & Patient Flow’, ‘Financial & Insurance Management’ and 'Patient Rights & Accessibility'. The cumulative explained variance for the six factors is 0.74 and cronbach alpha is between 0.88 - 0.97 (good - excellent) for all factors except factor 6 (0.61 - questionable). The factors identified follow a global pattern of issues identified from literature.

CONCLUSIONS

A data collection & processing pipeline made of python selenium, gpt-4o-mini model API, and factor analyzer module can run valid and reliable thematic analysis. Despite online reviews being subject to collection and information bias, insights from online analysis is real-time and can assist hospital managers to develop hypotheses and react to trending quality issues quickly once data collection & processing pipeline is established
R v Lufiau, R v Varennes, and The Gamble of Litigating a “Right” to Jury Trials Outside of Section 11(f)
Authors: Ampleman-Tremblay Sandrine
Published: November 2024

In light of recent events, changes to criminal law, and the advancement of social science, a renewed conversation on the right to select one’s mode of trial (or a right to a non-jury trial) under section 11(f) of the Charter is much needed. This paper aims to restart this conversation. To this end, the paper will briefly review the Lufiau and Varennes cases before discussing the risks of framing arguments on the “right” to a jury trial outside of section 11(f), like the parties did in these two cases. The last section of the paper will then expand on the drawbacks of the approach taken by the Supreme Court in R v Turpin, contrasting its argument with new social scientific studies and legal scholarship that challenge the impartiality and competence of juries.
Desempeño térmico de prototipo de techo verde bajo condiciones de calor extremo
Authors: Cuevas Acuña Génesis Anahí , Ayala Moreno Juan Pedro , Esquer Peralta Javier , Munguia Vega Nora Elba , Alvarado Ibarra Juana
Published: November 2024

Propósito: evaluar el desempeño térmico de un techo verde en un prototipo a escala en condiciones de calor extremo en clima cálido seco.
Diseño metodológico: el estudio es de carácter experimental y se desarrolló en cinco fases: revisión del estado del arte para elegir criterios de diseño de prototipos, diseño del prototipo base y del techo verde, construcción de los prototipos, medición de variables y análisis estadístico de los resultados.
Resultados: los resultados mostraron que el techo verde reduce significativamente la temperatura de bulbo seco promedio diaria interior, 4.03°C en promedio, estando dentro de la zona de confort térmico un 42.71 % del tiempo medido, mientras que el módulo base solo tuvo un 18.75 %. Se obtuvo un factor de decremento de 0.55 en el techo verde y 1.30 en el módulo base, así como un tiempo de retardo en alcanzar la temperatura máxima en la superficie interior de la losa de 4.86 horas para el techo verde y 1.16 para el módulo base.
Limitaciones de la investigación: los resultados obtenidos describen el comportamiento del prototipo bajo el calor extremo del verano, en futuros trabajos se deberá medir el comportamiento durante las cuatro estaciones.
Hallazgos: durante el tiempo de medición el prototipo verde mantuvo temperaturas más estables y menores comparadas con el módulo base, demostrando su eficacia para reducir la transferencia de calor y mejorar el confort térmico bajo condiciones de calor extremo en clima cálido seco.
Impact of Custodial Violence among Kal Oddar Women and Children in Mottamalai, Tamil Nadu
Authors: Arpudha G. , Shree T. Subhaa
Published: November 2024

Abstract: Kal Oddars have been identified and stigmatized as criminals. The stigmatization has an intricate effect in their daily life. Their fundamental and basic rights are constantly violated by the Government. Education, employment etc has been in the back of beyond for Kal Oddar community. The men are incessantly arrested by the police and are subjected to custodial violence which affects the women and children’s well-being. The study, “Impact of Custodial Violence on Kal Oddar Women and Children in Mottamalai, Tamil Nadu '' aims to bring out the effect of Custodial Violence on Women and children of the community. 10 case studies were discussed in this study. The respondents were selected based on Purposive Sampling technique to address the impact effectively. Analysis of the Case Study indicated that their everyday life is at stake. Women play the roles of both themselves and the men and are exhausted physically, emotionally and financially. Children drop out from schools and become involved in delinquent behaviour resulting in doubtful future. The prejudice held against them does not allow them to grow. The undefined social status of Kal Oddars should be redefined by the Government.
Development of SSIBL e-modules on ecology and biodiversity materials to improve critical thinking and motivation
Authors: Kusumasari Anggi , Suryawati Evi , Anwar Lenny
Published: November 2024

The development of SSIBL-based E-modules is motivated by the importance of critical thinking skills and learning motivation in science learning that must be possessed by students. It was found that the limited teaching materials used as well as critical thinking skills and student learning motivation were still in the low category in science learning. This study aims to test the effectiveness and feasibility of SSIBL-based E-modules on ecology and biodiversity material for Indonesian junior high school students, especially at SMPN 23 Pekanbaru. The type of research used is development research with the ADDIE method. The results of the validation of the SSIBL-based E-module assessment by material experts obtained an average score of 3.72 with a very feasible category. The results of the assessment validation by pedagogical experts amounted to 3.97 with a very feasible category. The results of the assessment validation by media experts amounted to 3.95 with a very feasible category. The effectiveness of the E-module with the MANOVA test obtained a sig value of 0.000. This means that there are differences in critical thinking skills and learning motivation between the experimental class using the SSIBL-based E-module and the control class that does not use the SSIBL-based E-module. Based on the results of this SSIBL-based E-module research, it is recommended that it can be used to improve students' critical thinking skills and learning motivation.
Development and Validation of UV Spectroscopic Method for the Quantification of Lamotrigine in Bulk and Marketed Formulations
Authors: Chagi Madhusri , Srinivasulu Neeladri , Anand Kumar Yegnoor , Polkal Pooja , Shetty Keerthana
Published: November 2024

Two Simple and precise UV spectroscopic methods were developed for the estimation of lamotrigine in bulk and marketed tablets. The methods developed by using two solvent systems viz., Methanol: Distilled water (1:1) and Acetonitrile: 0.1N HCl (1:1) were validated as per ICH guidelines. The two proposed solvent systems validated for linearity, accuracy, precision, robustness, ruggedness and solution stability. The percent recovery in the marketed tablet formulationswere found to be good agreement with the label claim. The methods validated statistically and the results suggest these methods can employed for the routine analysis of lamotrigine in bulk and marketed tablet formulations.
Development of Simple, Precise UV Spectroscopic Method for the Estimation of Escitalopram Oxalate in Bulk and Marketed Tablets
Authors: Polkal Pooja , Srinivasulu Neeladri , Anand Kumar Yegnoor , Shetty Keerthana , Madusri Chagi
Published: November 2024

Two new simple and accurate solvent mediums have been presented for the quantification of Escitalopram Oxalate (ESC) in tablet dosage form. A linear relationship found in the concentration range of 1-24 µg/ml for two proposed mediums viz., phosphate buffer pH 7.4 (Medium 1) and methanol: phosphate buffer pH 7.4 [1:1](Medium 2).The goodness of fit study suggests good correlation coefficient (R2 - 0.9998 and 0.9998 for proposed mediums) shows the validity of Beer’s law with intercept response < 2% calculated by the least square method indicating functional linearity between the concentration of analyte and the absorbance. Based on standard deviation of the response and slope, the LOD values for ESC for the proposed mediums found to be 0.348±0.00238 μg/ml, 0.273±0.0014 μg/ml and LOQ values found to be 1.046±0.002458 μg/ml, 0.823±0.00065 μg/ml with % RSD values less than 2.The proposed methods were successfully applied to the determination of commercially available tablets with a high percentage of recovery, good accuracy and precision.
Pharmacognostic standardization and quality control of stem bark of Cinnamomum cassia (L.) J.Presl
Authors: Devi Usha , Ahmed Anees , Ansari Shoeb Ahmed , Sattar Khan Asma , Meena Rampratap
Published: November 2024

Cinnamomum cassia (L.) J.Preslstem bark is one of the most popular spice used for cooking as well as in traditional and modern medicines. C.cassiais a tree of tropical region of Lauraceae family, commonly known as Chinese cinnamon. Bark has been used as anti-inflammatory, analgesic, antioxidant, antimicrobial, anti-obesity, mosquito larvicidal, anti-diabetic, antitumour, anti-tyrosinase activity and cardiovascular protective.Traditionally, it is used to cure dental problems, oral microbiota, and bad breath.In Indian traditional medicine, especially in Unani and Ayurveda, the bark is used medicinally to treat a various of illnesses, including diarrhoea, kidney pain, cough & cold, cobra bite, headaches, acne, dysuria, burning micturition, indigestion, weakness of liver, amenorrhea, fungal infection, weakness of liver and for the management of sexual dysfunction. Pharmacognostic studies help to validate crude drugs and set standardization parameters that can assist in the prevention of adulteration. The present study will help to set the specific macro-microscopicand physico-chemical parameters to identity C. cassia stem bark which certainly assurance the quality of crude drug and will definitely help in standardization of various traditional herbal formulations containing C.cassia stem bark as ingredient.
Revitalize Your Skin: A Comprehensive Review of Chemical peel
Authors: Patole Shravani Prakash , Naikawadi Nishigandha D. , Redasani Dr. V.K.
Published: November 2024

Recent years have seen tremendous progress in the realm of cosmetic science, with chemical peels becoming a well-liked method for improving and rejuvenating skin. In the field of cosmetic science, a chemical peel entails applying chemical solutions to the skin in order to induce controlled skin peeling and exfoliation. The goals of this operation are to minimize small lines, improve the texture of the skin, and treat conditions like hyperpigmentation or acne. The degree of skin penetration and the ensuing consequences are determined by the peel's depth. Chemical peels can be classified as superficial, medium, or deep, with each type providing unique advantages and things to think about. All things considered, they are essential for skin rejuvenation since they encourage the removal of damaged skin layers, exposing skin that is smoother and looks younger.
1,3,4- Thiadiazole and Its Derivatives- A Review on Syntheic Account and Recent Progress on its Phermoacological Activities
Authors: Mahadev Jadhav Kiran , Nandkumar Chitnis Akshata , Vishveswar Khandare Aishwarya , P.L Salve , V.J Pise
Published: November 2024

Many compounds containing a five-membered heterocyclic ring display exceptional chemical properties and versatile biological activities. The 1,3,4-thiadiazole nucleus is one of the most important and well-known heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. Thiadiazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti-inflammatory, analgesic, antifungal, antiepileptic, antiviral, antineoplastic, and antitubercular agents. The broad and potent activity of thiadiazole and their derivatives has established them as pharmacologically significant scaffolds. The current review focused on the various biological performances exhibited by 1,3,4-thiadiazoles.
Bioanalytical Method Development and Validation of Antihelmintic Drug in Human Plasma
Authors: Sapna Pandey A. , Jadhao Monika P.
Published: November 2024

Triclabendazole is an anthelmintic or anti-worm medication. Asimple and sensitive bio-analytical HPLC method with UV detection was developed and validated   triclabendazole in human plasma. The analytes were extracted from human plasma samples by liquid-liquid extraction technique. Triclabendazole showed maximum absorbance i.e.; λmax at 305 nm. The developed analytical method was validated as per ICH guidelines. The chromatographic separation was achieved with Hypersil BDS C18 (250 mm x 4.6 mm, Particle size: 5 µm), software Autochrom 3000 using a mobile phase composition of acetonitrile and  buffer (60:40 V/V) at a flow rate of 1.2 mL/min with a run time of 7 min.
The method showed good linearity in correlation coefficient (r) of >0.9998.  The LOD and LOQ were found to be 1.00 µg mL-1 and 3.02 mg mL-1, respectively. Accuracy and precision data were found to be less than 2%, indicating the suitability of method. The developed HPLC method in human plasma using protein precipitation extraction for sample preparation was found to be very simple, reliable, precise, accurate, sensitive and selective analytical method for the estimation of Tricalbendazole. The method is suitable for routine quantitative analysis in pharmaceutical dosage forms. The method developed can be used in therapeutic drug monitoring units, bioequivalence and bioavailability studies, pharmacokinetic and toxicology studies of Tricalbendazole.
Skin Aging and Herbal Anti-Aging Serums: A Comprehensive Review
Authors: Dileep Shintre Aniruddha , Dayanand Naikawadi Nishigandha , Redasani Dr. V.K.
Published: November 2024

This review explores the intricate anatomy of the skin, giving a brief synopsis of its structure and role. It describes the various aspects of skin aging and the roles that both intrinsic and extrinsic factors play in this process of aging. Focusing on the topic of herbal medicines, the article investigates the scientifically proven anti-aging properties of a variety of herbs. It also provides information about the composition and varieties of serums, emphasizing important components such hyaluronic acid, vitamin C, vitamin B3, and herbal extracts that are effective in preventing facial ageing. The aim of this review is to provide readers with a comprehensive understanding of skin aging and the wide range of anti-aging techniques accessible, especially in the context of herbal based face serum
Review on Antimicrobial Polyherbal Cream
Authors: Sonwalkar Viraj S. , Naikwadi Nishiganda D. , Redasani V.K.Redasani , Redasani V.K.
Published: November 2024

This review article explores the effectiveness of antimicrobial creams in addressing microbial infections and supporting skin health. It examines the mechanisms underlying microbial growth on the skin and the diverse range of antimicrobial agents utilized in cream formulations. Special emphasis is placed on the antimicrobial properties of various plants. Through comprehensive analysis, the article underscores the potential of antimicrobial creams as natural alternatives for managing skin infections and enhancing dermatological well-being.
A Systemic Review on Techniques of Solubility Enhancement for Poor Water-Soluble Drugs
Authors: Deshmukh Dr. Prasad , Nimkar Sangam , Phuse Amruta , Ruikar Dipti , Bonde Dipti
Published: November 2024

Background Investigating novel methods to improve solubility in order to increase drug absorption along with improving pharmaceutical formulations.
Main body of the abstractThe limited water solubility of active pharmaceutical ingredients constrains their pharmacological efficacy. However, the solubility parameter must not be compromised, necessitating the use of various strategies to improve their bioavailability. The solubility of drugs significantly impacts their pharmacokinetics, pharmacodynamics, as well as other characteristics like drug distribution, protein binding, and absorption. This review article aims to provide a concise overview of both traditional and innovative techniques employed to enhance the solubility of medications that have low solubility. These methods encompass several physical and chemical techniques, such as reducing particle size, creating solid dispersions, micronization using supercritical fluid technology, using cryogenic technology, utilizing complexation, employing hydrotrophy, employing crystal engineering, and developing solid self-emulsifying drug delivery systems. These various methods have contributed to improve the bioavailability of medications that are taken orally by enhancing the solubility of pharmaceuticals that have low water solubility.
Short conclusion Thereview offers comprehensive insights into tactics for enhancing solubility, along with the significance of solubility and the most recent strategies for augmenting it.
A Review of the Synthetic Account of 3-Methyl Pyrazolone as Anti-Inflammatory Agent
Authors: Nandkumar Chitnis Akshata , Mahadev Jadhav Kiran , Vishweshvar Khandare Aishwarya , Salve P. L. , Pise V. J.
Published: November 2024

Pyrazolone is a five-membered lactam ring containing two nitrogens and one ketonic group in its structure. Numerous pyrazolone derivatives were exhibited with diverse biological, pharmacological, and chemical applications. The chemistry of pyrazolone has gained increasing attention due to its diverse pharmacological properties such as anticancer, analgesic, anti-inflammatory, antimicrobial, antioxidant, antifungal, antiviral, antidiabetic, and several other biological activities. Thus, because of their importance, synthetic strategies for existing as well as novel pyrazolone derivatives have been developed and explored their biochemical utility. Medicinal chemistry researchers have synthesized drug-like pyrazolone candidates with several medicinal features. This review paper intends to collect the references and comprehensively summarize the biological activity and the synthetic account of 3-methyl pyrazolone as an anti-inflammatory agent.
Pharmacological evaluation of cellular and molecular mechanism of Anti-Inflammatory and Immunomodulatory effects of traditional herbal drug extract of Hedychium spicatum in Experimental Models of Bronchial Asthma
Authors: Gulati Kavita , Sharma Hemlata , Thokchom Suresh , Verma Pankaj , Ray Arunabha
Published: November 2024

The study assessed the effects of standardized extracts of Hedychium spicatum on airway inflammation and immunomodulatory parameters in experimental model of bronchial asthma in rats. Wistar rats were immunized with ovalbumin (OVA) adsorbed on to aluminium hydroxide (i.p.) and challenged with aerosolized ovalbumin from day 15 to 22.  Standardized extracts of Hedychium spicatum were administered orally for 22 days in different treatment groups. After 24h of last challenge, rats were anesthetized and blood and bronchoalveolar lavage fluid (BALF) were collected, centrifuged and analyzed for proinflammatory cytokines TNF-α, NF-κB, Th2 type cytokines IL-4 and cell count.The results showed that eosinophil cells levels were elevated in the immunized rats which were reduced in the treatment group Hedychium spicatum extract as compared to control. These results were comparable with the effects of the standard drug prednisolone. The results showed that extract of Hedychium spicatum has anti-inflammatory and immunomodulatory effects. Thus, the results suggest that the beneficial effects of Hedychium spicatum in bronchial asthma could be due to balancing influence on prooxidant-antioxidant status and reducing the airway inflammation.
Formulation and Evaluation Immediate Release Mucoadhesive Buccal Tablet of Midodrine HCL
Authors: Tikait Aditi Vijay , Wankhade Vikrant P. , Mhaske Yukta , Atram Sandeep C. , Bobade Nishan N. , S. D. Pande
Published: November 2024

This study aimed to develop and optimize immediate-release mucoadhesive buccal tablets of Midodrine Hydrochloride, intended for rapid onset of action in treating hypotensive states. The tablets were prepared using a direct compression method, with various formulations optimized through a 32 randomized full factorial design, focusing on Crospovidone and Carbopol 934P as independent variables affecting diffusion time and mucoadhesive strength. The optimized batch F3 demonstrated superior performance, with a disintegration time of 20 seconds and an in vitro release of 98.25% within 5 minutes, meeting the criteria for immediate release. Additionally, F3 exhibited strong mucoadhesive strength, ensuring prolonged retention in the buccal cavity, and an appropriate surface pH of 6.8, compatible with the buccal environment. Stability studies conducted according to ICH guidelines confirmed that the optimized formulation maintained its integrity and efficacy under accelerated conditions. The findings suggest that the optimized F3 formulation is highly effective for buccal delivery of Midodrine Hydrochloride, offering a promising therapeutic option for patients requiring rapid antihypotensive action. The tablets exhibited efficient mucoadhesive strength, appropriate surface pH, and rapid drug release, making them promising for effective buccal drug delivery of Midodrine Hydrochloride.
Unlocking Ancient Remedies: Berberis Aristata Extract as a Lead Candidate, Exploring the Potential of Indian Sarsaparilla for Combating Drug-Resistant Bacteria
Authors: Sakpal Prerana , Bansode Ankita S. , Mhatre Sanjivani , Hamza Ameer , Chormale Abhijeet , Pandey Satyam
Published: November 2024

The emergence of drug-resistant bacteria poses a significant threat to global health. This study investigated the potential of plant extracts as a source of novel antibacterial agents. The antibacterial activity of various plant extracts was evaluated against common pathogenic bacteria, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Among the tested extracts, Berberis aristata (sample 3) and Indian sarsaparilla (sample 4) displayed notable broad-spectrum antibacterial activity.
Minimum Inhibitory Concentration (MIC) determination using the Resazurin Microtiter Assay (REMA) revealed the superior potency of Berberis aristata compared to Indian sarsaparilla. This finding suggests that Berberis aristata extract exhibits antibacterial activity at lower concentrations, highlighting its potential for further development as a therapeutic agent.
These results highlight Berberis aristata as a promising natural source for the development of novel broad-spectrum antibacterial agents to combat drug-resistant bacteria. Further research is warranted to elucidate the mechanisms of action of Berberis aristata and to assess its efficacy and safety in vivo models. Additionally, establishing standardized extraction protocols and quality control measures is necessary for consistent results and future therapeutic applications.
Solubility Enhancement by Solid Dispersion Method: An Overview
Authors: Vaishnavi Jadhav  , Pooja Kashid  , Kishor Otari  , Mohini Yadav
Published: November 2024

To improve dissolution of poorly water-soluble drugs and thus enhancing their bioavailability, the dispersion of one or moreactive pharmaceutical ingredient in a carrier at solid state is used. This process is known as solid dispersion. It has engrossed significant interest as an efficient means of improving the dissolution rate. It happens due to dispersions of poorly water-soluble drugs with water-soluble carriers. The one of the most challenging aspects in formulation development is solubility behaviour of drugs. The number of poor water-soluble compounds has radically increased. Compared to conventional formulations such as tablets or capsules, solid dispersions prepared by various methods can be used which have many benefits over the above conventional dosage form. For the preparation of solid dispersions, few of the aspects are to be considered such as; selection of carrier and methods of physicochemical characterization. In this review, an emphasis is put on solubility, various types of solid dispersions, BCS classification, carriers, solid dispersion techniques, mechanism to enhance dissolution in solid dispersion, characterization, advantages, disadvantages and the application of the solid dispersions.
An overview of floating tablet
Authors: Borude Shubham Sakharam , Mandhare Trushali A. , Pooja S.Kashid  , Otari Kishor
Published: November 2024

Flash nanoprecipitation (FNP) is a widely used technique for preparing particulate carriers based on various polymers that has been shown to be a promising technology for the industrial production of drug-loaded nanoparticles. The use of amphiphilic block copolymers as a stabilizer to protect the nanoparticles from aggregation makes flash nanoprecipitation (FNP) an ideal method for rapidly preparing nanosized drug particles with high drug-loading efficiency. Flash nanoprecipitation (FNP) is a controlled antisolvent precipitation process that has been shown to be effective for producing drug nanoparticles with a defined mean particle size and narrow particle size distribution. However, the physical instability of the generated nanoparticles remains a significant barrier to the use of this technology in pharmaceutical formulation. This review discusses the use of FNP to create poorly water-soluble drug nanoparticles using controllable mixing devices such as confined impinging jets mixers (CIJM), multi-inlet vortex mixers (MIVM), and a variety of other microfluidic mixer systems. The mechanisms and processes of drug nanoparticle formation by FNP are described in detail. Then, during the FNP process, the supersaturation level and mixing rate are controlled to tailor the ultrafine drug nanoparticles, as well as the influence of drugs, solvent, anti-solvent, and stabilizers. The control of supersaturation level and mixing rate during the FNP process to tailor ultrafine drug nanoparticles is discussed, as well as the influence of drugs, solvent, anti-solvent, stabilizers, and temperature on fabrication.
EXAME DE PAPANICOLAU E DIAGNÓSTICO PRECOCE: Um estudo populacional em uma UBS de Carmo do Paranaíba - MG
Authors: Oliveira Ana Flávia Sabino de , Bernardino Istella Cristina
Published: November 2024

This course completion work certified the importance of the Pap smear, the relevance of an early diagnosis, the number of women who underwent it during the period from 2022 to September 2024, age group and its results in the city of Carmo do Paranaíba, Minas Gerais, Brazil. The data were taken from the local Health Department, authorized by the head nurse of the Basic Health Units. It was noted that the performance of the Pap smear showed variations over the years. In 2022, there was a considerable increase, followed by a decrease in 2023, while in 2024 the number of women taking the exam continues to grow. According to my investigation, the age range of the women who most underwent the exam varies between 30 and 59 years old. It is interesting to note that, of the 678 tests carried out, 617 showed changes, while only 61 were within normal limits. These data demonstrate that conditions such as candidiasis, inflammation and cervical cancer are more common than we imagine. Therefore, it is essential to monitor your health and perform a Pap smear every 1x a year, as this increases the likelihood of an early and effective diagnosis.
Tras la devastación que ha traído las inundaciones pluviales, más sociología
Authors: García Calavia Miguel Angel
Published: November 2024

La terrible devastación que ha asolado la Comunidad Valenciana es una oportunidad para seguir examinando de manera pormenorizada los efectos de las inundaciones pluviales, también para seguir reflexionando sobre cómo conseguir sociedades más seguras y sostenibles; menos desiguales y más democráticas. Sociólogas y sociólogos la están aprovechando, continuando así el análisis y la reflexión iniciado hace décadas.
BAIÃO DOS SABERES:
Authors: Sousa Gerson Carlos Matias de
Published: November 2024

O artigo discorre sobre as experiências de ensino/aprendizagem e composição de danças cênicas desenvolvidas pela Cia Balé Baião (Itapipoca-CE), que ao longo de vinte cinco anos vem atuando na região do Litoral Oeste/Vale do Curu, enfocando seu ativismo, atravessamentos estéticos, técnicos e éticos em confluência com a Educação Biocêntrica, e as bases que fundamentam as metodologias adotadas pela Escola Livre.
Embedding rehabilitation into cancer care continuum: an implementation study
Authors: Khan Fary , Amatya Bhasker , Elmalik Alaeldin , Song Krystal , Diaz Demi , Dickinson Michael
Published: November 2024

Objectives: To implement and evaluate a rehabilitation-inclusive service delivery model at a tertiary cancer hospital.
Methods: The “Rehab-Toolkit”, a structured assessment tool comprising validated functional measures, was introduced in an inpatient cancer service. Consecutive inpatients were enrolled, and a Reach, Effectiveness, Adoption, Implementation, and Maintenance framework guided the analysis of barriers and facilitators for subacute care at clinic and system levels.
Results: The implementation of the Rehab-Toolkit was incorporated into routine inpatient care. Major pre-implementation barriers included: absence of routine standardized functional assessment tools, limited coordination amongst acute and subacute care providers, low awareness of rehabilitation medicine amongst patients and professionals, and insufficient engagement of subacute care with interdisciplinary stakeholders in clinical decision-making. Following the intervention, there was a notable increase in awareness and the contributory role of subacute rehabilitation services, rehabilitation “needs” assessment, and referral pathways. Recommendations for process change included: development of clinical pathways, establishment of subacute referral systems and discharge coordinator roles, inclusion of subacute rehabilitation services in acute interdisciplinary team meetings, enhanced staff education and knowledge.
Conclusion: Integration of rehabilitation services into cancer care can proactively manage functional morbidity. While the implementation process proved feasible and effective, robust process evalu-ation and longer term follow-up are necessary for sustained success.
Из опыта применения математического моделирования в процессе обучения студентов вузов математическим дисциплинам прикладного характера
Authors: С.А. Парыгина
Published: November 2024

В статье рассмотрен пример применения реального математического моделирования в ходе обучения студентов разных направлений подготовки прикладным математическим дисциплинам, а именно: построение регрессионной математической модели, позволяющей регулировать влияние входных переменных на выходную переменную, с целью уменьшения такого распространенного дефекта как коррозия металла. В ходе моделирования выделено 10 значимых производственных факторов, выбрано уравнение множественной линейной регрессии этих факторов на выходную переменную Y, определяющую процент брака по причине коррозии. Значение коэффициента детерминации, равное 0,96, говорит о достаточно высокой точности моделирования. Детальное проникновение в суть построения математической модели позволяет студентам лучше понять алгоритм и нюансы реального математического моделирования.

The article considers using real mathematical modeling in the course of teaching students of different fields of study in applied mathematical disciplines, namely, building a regression mathematical model that allows regulating the influence of input variables on the output variable in order to reduce such a common defect as metal corrosion. During the process of modeling, 10 significant production factors were identified, an equation for multiple linear regression of these factors on the output variable Y was selected, which determines the percentage of defects due to corrosion. The value of the determination coefficient, equal to 0.96, indicates a fairly high accuracy of modeling. Detailed insight into the essence of constructing a mathematical model improves the students comprehension of the algorithm and real mathematical modeling nuances.
Selection and Evaluation of Thermo-tolerant Yeast Isolates for Sugar Tolerance
Authors: Jayamma P. , Shirnalli G. Geeta , Nagalakshmi S. , Aruna R.
Published: November 2024

The experiment was carried out during October, 2020 to January, 2022 in the Department of Agricultural Microbiology, College of Agriculture, University of Agricultural Sciences, Dharwad, Karnataka, India to evaluate the ability of thermotolerant yeast strains isolated from various fruit wastes to produce ethanol. Yeast strains should be able to grow in media with a high level of sugar concentration in order to produce high levels of ethanol. An improved yeast strain that can withstand high sugar concentrations will be able to use more carbohydrates and yield more ethanol. The ability of thermotolerant yeast strains isolated from various fruit wastes to produce ethanol was studied. A total of 100 and 10 yeasts isolates were obtained from several fruit wastes and tested for thermotolerance by growing in Yeast extract dextrose peptone broth at varied temperatures, namely 35, 40, and 45°C. Among these, 20 yeast isolates were successfully grown at 35, 40, and 45°C and were identified using morphological and biochemical methods. Further all the 20 thermotolerant isolates were screened for sugar tolerance. The broth medium was supplemented with different glucose concentrations ranging from 10 to 25% (w/v) and incubated at temperature (35, 40 and 45°C), time (24, 48, 72, and 96 h) and growth was measured by OD at 600 nm. Among 20 isolates, four (YP11, YM17, YPA48 and YPA64) were tolerant to glucose at 25.0% (w/v). The objective of this research was to isolate and characterize thermotolerant and sugar tolerant yeast to optimize maximal ethanol production from fruit waste.
Studies on the Impact of Various Cultivation Practices on Phytochemical Parameters of Broccoli
Authors: Meena Pooran Mal , Aggarwal R. K. , Thakur Abhimanyu
Published: November 2024

The experiment on studies on the impact of various cultivation practices on phytochemical parameters of Broccoli (Brassica oleracea var. italica L.) was conducted during the rabi season of 2021–2022 with 3 transplanting dates (8th October, 28th October and 18th November 2021) followed by 3 subsequent harvesting dates (29th January, 8th March and 19th February, 2022) at the Research Farm, Department of Environmental Science, College of Forestry, Dr Yashwant Singh Parmar University of Horticulture and Forestry, Nauni, Solan, Himachal Pradesh, India. After harvesting the crop different phytochemical parameters were analysed for studying the effects of different treatments. The highest content of various phytochemical compounds like Total Soluble Solids (TSS), carotenoids, total phenols, glucosinolates, ascorbic acid, protein, total sugar, total chlorophyll, antioxidants, titratable acidity, anthocyanin, total lipids, etc. was reported in crop sown in the mid-season during the first week of October and followed by transplanting at the end of the same month. The mulching and irrigation practices also led to have increased concentration of these biochemical components in the Broccoli. In the case of mid-season transplanted, mulched and irrigated broccoli, the various biochemical compounds like carotenoids, total phenols, glucosinolates, ascorbic acid, protein, chlorophyll, anthocyanins and total antioxidants were reported 26.32, 20.13,10.27, 58.42, 16.56, 27.03, 28.70 and 16.76% respectively higher than the control samples and these cultivation practices were further recommended for the quality production of broccoli.
Características associadas à percepção de familiares quanto à importância do Selo Ruído do Inmetro para brinquedos infantis
Authors: Felix Michelle Vieira , Hillesheim Danúbia , Zucki Fernanda
Published: November 2024

Introdução: A exposição a níveis de pressão sonora elevados é um problema da sociedade moderna, especialmente na população infantil. Objetivo: Analisar as características associadas à percepção de familiares quanto à importância do Selo Ruído do Inmetro para brinquedos infantis. Métodos: Estudo descritivo de delineamento transversal, com amostragem não probabilística, por conveniência. Os dados foram coletados por meio de questionário respondido por pais e/ou responsáveis de crianças entre zero e cinco anos. Resultados: A maior prevalência de indivíduos que conheciam a importância do Selo Ruído do Inmetro foi entre os responsáveis (66,7%), pessoas do gênero masculino (36,4%), entre 18 a 29 anos de idade (37,5%), de cor/raça preta (60,0%) e com até um filho (29,2%). A característica considerada ao comprar um brinquedo, que foi mais referida pelos participantes, foi a habilidade que o brinquedo estimula (92,3%). Houve maior conhecimento da importância do Selo Ruído entre aqueles que: consideravam a saúde auditiva da criança na compra do brinquedo (46,2%), consideravam a certificação do Inmetro na compra do brinquedo (41,7%), sabiam o que era perda auditiva (29,2%), os filhos brincavam com brinquedos sonoros de três a quatro dias por semana (40%) e que não compram brinquedos sem o selo (31,8%). O volume referido dos brinquedos obteve mediana de cinco pontos, variando de um a 10. Conclusão: Os familiares que conheciam a importância do Selo Ruído do Inmetro levaram em consideração a saúde auditiva da criança e a certificação do Inmetro na compra de um brinquedo quando comparado aos demais.
Gestão do acompanhamento audiológico de adultos e pessoas idosas usuários de aparelho de amplificação sonora individual
Authors: Sault Taiane Cristina Leite da Silva , Novaes Beatriz Cavalcanti de Albuquerque Caiuby , Mota Marcia Ferreira , Mendes Beatriz de Castro Andrade
Published: November 2024

Objetivo: O objetivo deste estudo é analisar os motivos pelos quais os usuários de AASI solicitam atendimento no serviço de referência, levando em consideração as necessidades e características audiológicas dos usuários, bem como a equipe e os procedimentos realizados. Sendo assim, um dos objetivos desta pesquisa é encontrar e classificar a demanda de retorno dos usuários para encontrar soluções para a crescente demanda. Método: Este é um estudo prospectivo e transversal. Participaram do estudo adultos (maiores de 18 anos) usuários de AASI que solicitaram retorno durante o mês de agosto de 2020. A amostra deste estudo foi composta por 177 participantes. Resultados: A maioria das pessoas, com a média de idade de 62,84 anos, possui grau leve a moderado de perda auditiva neurossensorial. O mau funcionamento dos aparelhos auditivos e a necessidade de modificações encabeçavam a lista de preocupações dos cuidados diários. A maioria dos participantes necessitou de uma equipe de cuidados integrais, enquanto os demais necessitaram apenas de uma equipe de cuidados básicos. Os sujeitos necessitaram de acompanhamento audiológico, troca de AASI, ajustes do AASI e, em alguns casos, questionamentos sobre moldes auriculares ou laudos médicos relacionados à conduta profissional realizada. Conclusão: Concluímos que a idade do AASI e a data da última audiometria ajudaram a formar a equipe e o tipo de consulta.
NILAI-NILAI PENDIDIKAN DALAM UMPASA PADA ADAT PERKAWINAN BATAK TOBA
Authors: Simanjuntak Aknes , Januarsyah Daulay Mhd. Anggie
Published: November 2024

AbstrakPenelitian ini bertujuan untuk mengetahui Nilai-nilai Pendidikan Dalam Umpasa Pada Adat Perkawinan Batak Toba dengan kajian Sosiologi Sastra. Jenis penelitian yang dipakai adalah penelitian kualitatif dengan metode penelitian deskriptif yang menggambarkan atau melukiskan gejala dan fakta secara sistematis. Teknik pengumpulan data yang digunakan untuk memperoleh data yaitu dengan menyimak rekaman video dan wawancara. Dari hasil penelitian diperoleh Nilai-nilai pendidikan yang terdapat dalam umpasa pada Adat Perkawinan Batak Toba yaitu nilai religius terdiri dari 12 buah umpasa, nilai moral terdiri dari 4 buah umpasa, nilai sosial terdiri dari 6 buah umpasa dan nilai budaya terdiri dari 3 buah umpasa. Dari data tersebut, maka dapat diketahui bahwa nilai pendidikan yang paling dominan yaitu nilai religius sebanyak 12 buah umpasa. Penulis berharap ada penelitian lanjutan yang lebih mendalam terhadap Nilai-nilai Pendidikan Dalam Umpasa Pada Adat Perkawinan Batak Toba dengan kajian yang berbeda untuk mendapatkan hasil kajian yang lebih sempurna.Kata kunci: Nilai Pendidikan, Perkawinan Batak Toba, Umpasa
ANALISIS SOSIOLINGUISTIK DALAM FILM TENGGELAMNYA KAPAL VAN DER WIJCK
Authors: Saimuary Dana Indah , Simbolon Imelda Meilani , Hutabarat Rindu L.W.
Published: November 2024

Abstrak Penelitian ini bertujuan untuk mendeskripsikan keterkaitan sosiolinguistik serta penerapannya terhadap film Tenggelamnya Kapal Van der Wijck. Data yang digunakan dalam penelitian ini adalah seluruh aspek kajian perspektif karya yang meliputi tema, diksi, gaya bahasa, imaji, dan amanat dalam film Tenggelamnya Kapal van der Wijk yang menggambarkan pengaruh adanya aspek sosiologi dan linguistik terhadap film Tenggelamnya Kapal Van der Wijck. Penelitian ini menggunakan metode dekriptif dengan pendekatan kualitatif. Teknik pengumpulan data pada penelitian ini adalah Teknik menonton, menyimak dan mencatat. Teknik dilakukan dengan menonton film, menyimak, kemudian dicatat untuk dianalisis berdasarkan kajian perspektifnya. Hasil penelitian yang diperoleh membuktikan sosiolinguistik sangat berpengaruh terhadap unsur pembangun film Tenggelamnya Kapal Van der Wijck.       Kata Kunci: Sosiolinguistik, Film, Kajian Perspektif.