bluuebunny/crossref_metadata_2025 huggingface dataset:
Knocking Down the Pillars of Democracy in Europe: Politicisation of Science and Law in Response During COVID-19
Authors: Simons Gregory John
Published: November 2024

The European Parliament has stressed on numerous occasions in public documents and speeches its non-conditional support for the principles of democracy, the rule of law, good governance, respect for human rights and fundamental freedoms. Yet as the pandemic has developed these principles have not been defended by various member states of the EU, being traded for public health and public good. This presentation seeks to critically analyse the content of key rhetoric and narratives from the outbreak of the pandemic until the present time through public statements that shall be contrasted against the “unconditional principles” above within the theoretical frame of Situational Crisis Communication Theory. Attention shall be paid to key political officials and understand the role of mainstream mass media and social media as gatekeepers of the orthodoxy of knowledge established. Orthodoxy of knowledge is group consensus on defining and constructing ‘realities’ in the physical realm, even when the consensus is coerced. Given the increasing lack of scientific debate, which is a fundamental element of good scientific practice, and the use of heavy handed and largely unsuccessful responses to the virus (such as lockdowns, vax passports and vaccination campaigns), Europe (not only) is in a precarious position in terms of its societal principles and practice. Crisis management is expediently rushed through face of fear and time constraint based upon a lack of consideration for the consequences and long-term effects, some of which are already emerging but being silenced. Hence a creeping crisis of significant psychological and physical impact is in the making.
The Resilient Agility of Brand Voice in Volatile Environments
Authors: Surikova Jūlija
Published: November 2024

In an era marked by rapid change, the role of brand voice within brand communication has become increasingly vital to protecting brand identity, moving beyond traditional marketing approaches. This research introduces the concept of “resilient agility” of brand voice and examines it in a variety of uncertain contexts. Aiming to investigate the potential influence of volatile environments on brand voice within the context of brand communication, the author based her research on the examination of various case studies and as a result introduced two new models of projecting brand identity through brand communication, including one tailored for volatile environments. The author identifies the resilient agility of brand voice in projecting the essence of brand identity, consistency in core messaging, and transparency in addressing issues as key success factors for brand communication. This research enhances the understanding of the projection model of brand identity through brand communication, especially in volatile environments, offering valuable insights for marketers aiming to maintain brand integrity and develop lasting customer relationships amidst uncertainty.
Role of kiwifruit in the inhibition of carcinogenesis: Proof-of-concept from cell culture studies and xenografted mice
Authors: Romero Mirna Azalea , Fayyaz Sundas , Tariq Mahrukh , Attar Rukset , Farooqi Ammad Ahmad
Published: November 2024

Kiwifruit initially gained the limelight because of its remarkable health benefits. Still, its mechanistic involvement in the chemoprevention of carcinogenesis and metastasis has enabled researchers to evaluate anticancer and anti-metastatic effects in cell culture studies and xenografted mice. Interdisciplinary researchers have witnessed groundbreaking discoveries related to the pharmacological targeting of oncogenic proteins by kiwifruit in xenografted mice. Therefore, kiwifruit extracts, bioactive molecules, and nanovesicles have been investigated in different cancers. Although its importance was previously unrecognized, kiwifruit-derived nanovesicles are expected to showcase an increasingly prominent role in the chemoprevention of cancer as strategically preferable delivery vehicles. Accumulating evidence has started unraveling pleiotropic regulation of protein networks and biochemical modifications by kiwifruit in various cancers. Ubiquitination, autophagy, and mitophagy are some of the critical pathways reported to be regulated by kiwifruit extracts and bioactive chemicals. Nevertheless, realistically, this is the beginning of a new era in the context of mechanistic regulation of a myriad of cell signaling cascades in the prevention of carcinogenesis and metastasis.
Cardiotoxicity in Oncology: Prevention and Management Through Cardiovascular Rehabilitation
Authors: Popescu Gabriela , Leon Maria-Magdalena , Maștaleru Alexandra , Oancea Andra , Mitu Florin
Published: November 2024

With advancements in screening, diagnosis, and treatment, cancer-related mortality is declining, and life expectancy for cancer patients is increasing by up to 30%. However, these patients often face increased cardiovascular risks due to hypertension, metabolic syndrome, and type 2 diabetes, as well as the cardiotoxic effects of cancer therapies. Chemotherapy drugs like anthracyclines, trastuzumab, and 5-fluorouracil can hurt the heart through oxidative stress, apoptosis, and mitochondrial dysfunction. This can cause heart failure, coronary heart disease, and arrhythmias, among other problems. Cardiovascular rehabilitation (CR) has emerged as a key strategy to mitigate these effects. Studies involving breast cancer patients and other cancer populations have demonstrated that CR programs, involving high-intensity interval training and moderate-intensity exercises, improve cardiorespiratory fitness and reduce cardiovascular risks in cancer patients. Despite challenges such as patient reluctance due to distance from specialized centers, telerehabilitation has proven to be a viable alternative. CR not only improves peak VO2 but also reduces systemic inflammation and promotes muscle mass gain while lowering mortality and healthcare costs associated with post-cancer therapy complications. Multidisciplinary involvement-integrating cardiologists, oncologists, psychologists, and nutritionists-enhances outcomes, improving both cardiac fitness and quality of life for cancer patients. Further research highlights the need for early intervention and customized CR programs to minimize cardiovascular toxicity and optimize patient recovery post-chemotherapy.
The efficacy and safety of aerosol therapy in rhinology
Authors: Enache Raluca , Sarafoleanu Codrut , Vicheva Dilyana
Published: November 2024

Aerosol drug administration has a long history as an important part of the treatment for different respiratory disorders in both adult and paediatric patients. The nebulization process permits the drug delivery directly to the upper and lower airways tracts, allowing increased local effectiveness, and avoids systemic side effects. The aerosol therapy is mainly used in pneumology for lower respiratory tract disorders, a series of drugs having a proven efficacy. Few publications present the efficacy and safety of ENT nebulization, despite its worldwide utilization.

Topical drug delivery to the nasal cavities and paranasal sinuses via aerosols appears to be an interesting, but also a challenging alternative. The transport and deposition of drugs and aerosol particles into the sinuses is debatable due to several factors: sinuses are poorly perfused and virtually non-ventilated cavities; they are protected by the efficient particle filtration function of the nasal cavities. The review evaluates the efficacy and safety of aerosol therapy in rhinologic pathology.
Dysphonia in children
Authors: Milea Andreea , Milea Alex , Sarafoleanu Codrut
Published: November 2024

Dysphonia is a frequent symptom in paediatric patients and it has a prevalence between 6 - 24%. In young patients, dysphonia has a direct importance because it impairs their communicative behaviour, their psychological status and also their social life.

The most diagnosed voice pathologies in children are vocal nodules followed by vocal cord cysts, infectious and inflammatory causes, sulcus vocalis, laryngeal membranes, iatrogenic vocal cord paralysis, neurological causes, psychogenic factors, traumatic or irritative factors or, less commonly, laryngeal neoplasms.

A correct diagnosis of dysphonia in paediatric patients is important for learning, voice training and their psychological development. Children with dysphonia have to be assessed with adequate equipment. It is recommended to use tools that are appropriate to the tolerance and cooperation of the patients and allow to have a good visualization of the vocal folds. Suitable preventive methods, early diagnosis, appropriate treatment of voice disorders should be taken into consideration in these cases.

In this article, some of the most frequent causes of dysphonia in paediatric patients and their treatment options in order to achieve a proper voice are reviewed.
Comparison of histopathological diagnoses of ENT diseases in the COVID-19 pandemic with other periods
Authors: Kandemir Suheyla , Pamuk Ahmet Erim , Yigit Tuba
Published: November 2024

OBJECTIVE. It is aimed to reveal the frequency of histopathological diagnosis in ENT diseases during the COVID-19 period and whether it is different from diagnoses in other periods.

MATERIAL AND METHODS. The files of 1442 patients diagnosed with pathological material in the ENT clinic between 2017 and 2022 were retrospectively scanned. Two groups were created: the 1st group of patients between 2017-2019 (non-COVID-19 period) (Group 1) and the 2nd group of patients between 2020-2022 (COVID-19 period) (Group 2).

RESULTS. Pathological samples were sent from 1163 patients in Group 1 and from 279 patients in Group 2. Of 1442 patients, 815 were male and 627 were female, and the mean age was 25 (3-94 years). There was a statistically significant difference between the groups in terms of age (p=0.001). There was no significant difference in terms of gender (p=0.756). The most common histopathological diagnoses in both periods were chronic tonsillitis lymphoid hyperplasia (bilateral tonsillectomy + adenoidectomy) (19.5%), chronic inflammation lymphoid hyperplasia (adenoidectomy) (19.3%) and nasal polyp (19.2%). The incidence of malignant tumors was found to be 1.4% in Group 1 and 2.8% in Group 2. The incidence of benign tumors was found to be 7.6% in Group 1 and 12.8% in Group 2. In terms of frequency, the ratio of malignant and benign tumors was higher in Group 2.

CONCLUSION. The number of patients with histopathological diagnoses decreased due to the decrease in hospitalizations during the COVID-19 period. Delayed diagnosis in malignant pathologies significantly worsens the prognosis. All these results show that new cancer diagnostic strategies are needed for epidemic diseases such as COVID-19.
The acute effects of the PAP treatment on nasal mucosa in patients with OSAS
Authors: Oguz Oguzhan , Iriz Ayse
Published: November 2024

BACKGROUND. Obstructive sleep apnea syndrome (OSAS) is a common disease in developed countries. PAP (Positive Airway Pressure) therapy is the most commonly used treatment modality, particularly in moderate to severe OSAS patients. However, several side effects make PAP treatment challenging to tolerate. This study examined the acute effects of PAP treatment on nasal functions.

MATERIAL AND METHODS. This study included 32 patients who were diagnosed with severe OSAS following a PSG test and started PAP treatment. Symptom analysis was carried out with the SNOT-20 questionnaire; nasal physiological analysis was carried out with rhinomanometry and acoustic rhinometry tests performed before and after PAP treatment for one night and for one month. A saccharin test was carried out to assess the nasal mucociliary clearance before and after the treatment.

RESULTS. A statistically significant difference between nasal symptom scores (p=0.003) and sleep quality (p=0.006) was observed in SNOT-20 questionnaire results. Total nasal resistance was significantly increased after one night’s sleep with PAP and after a one-month treatment with PAP. It was found that there was a statistically significant relation between the total nasal resistance value and PAP pressure.

CONCLUSION. This study shows that PAP treatment increases nasal congestion after one night of treatment and after one month of treatment with a cumulative effect. PAP therapy positively affects sleeping quality and life quality, while negatively affecting nasal functions in the acute period.
Human Capital Development, Income Inequality and Public Sector Investment in Nigeria
Authors: Ogbeide-Osaretin Evelyn Nwamaka , Shedrack Ifeanyi , Aliu Timothy
Published: November 2024

Human capital development of any country is believed to be the bedrock for sustainable economic development which seems to be linked to the level of income inequality. But there seems not to be an implied acceptance of flow of the linkage as evident from the high level of income inequality and low level of human capital development. Suspected among the causes of this is the role of the public sector. Thus, the objective of this study is to determine if there exists a dynamic feedback impact between human capital development and income inequality given public sector investment in Nigeria. The study employed the ARDL and NLARDL estimation method using data on human capital development index, income inequality, government expenditure in health and educational sector, among other variables for the period 1991-2022. Human capital development and income inequality were found to have feedback impacts. Public sector investment was found to be crucial while the existence of Kuznet’s hypothesis was established. Hence, the study strongly advocates for policy measures of pro-poor growth, reduction of unemployment, population growth and the degree of trade openness for the effective reduction in the country’s inequality gap and the development of human capital.
Effects of Financial Inclusion and Out of Pockets Cost on Human Health (1990 - 2020)
Authors: Akintunde Temitope Sade , Oladimeji Ifeade Adetutu , Aribatise Adekunle
Published: November 2024

This study examined the dynamic relationship amongst financial inclusion, out of pocket expenditure and health outcome proxied by life expectancy. This was with the view to investigate the effects of financial inclusion and out-of-pocket medical expenses on health outcomes as well as the causal connections between various variables in Nigeria. Time series data from 1990 through 2020 were analysed using Autoregressive Distributed Lag (ARDL) and pairwise granger causality as the estimation technique. The study found a positive relationship between financial inclusion and health outcomes and there was a bidirectional causal relationship between financial inclusion and life expectancy and a unidirectional causal relationship running from out-ofpocket expenditure to life expectancy at 5% significance level and vice versa. The study also revealed that financial inclusion had a positive and significant effect on life expectancy in Nigeria. Also, out of pocket expenditure had revealed not to be statistically significant on life expectancy in the long-run.
Women in Accounting in Communist and Post-Communist Romania: Academia Case Study
Authors: Deaconu Adela , Puşcaş Georgiana , Nistor Cristina Silvia , Filip Crina Ioana
Published: November 2024

We investigated whether there are differences in women’s progress in Romanian accounting academia between the communist and post-communist periods, and compared to the international context; and whether the legal framework in Romania influenced women’s accounting careers in academia. For the communist period, we found that for our topic training for the exercise of the profession, the evolution of women’s academics, although it did not exceed that of men, outperformed that of women in other contexts, especially in Anglo-Saxon countries. Then, our findings were similar to the international context for teaching and leadership in academia. For the post-communist period, we observed Romanian academics’ similitude in teaching and bachelor studies and superiority in scientific publications and doctoral studies compared to their international counterparts. Also, the complexity of provisions assuring general or women’s rights, as well as the pace of their issuance aligned with women’s experiences in accounting academia.
Dynamic Stochastic Panel Analysis of FDI Inflows, Employment Generation and Poverty Reduction in Some Selected ECOWAS Countries
Authors: Omitogun Olawunmi , Omoyele Olufemi Samuel , Awomailo Lanke B. , Olanipekun Wahid Damilola , Aderemi Timothy Ayomitunde
Published: November 2024

Background and aim: Foreign direct investment (FDI) has historically played a vital contribution in promoting the economic growth and development in many undeveloped countries by creating jobs opportunities and facilitating technology transfer. However, over the past decade, the ECOWAS region has experienced a steady decline in FDI inflows, resulting in a shortfall in investment needed for initiatives aimed at enhancing employment. In light of this, the study explores the dynamic stochastic interactions between reduction in poverty, employment provision and foreign direct investment inflows among ECOWAS subregion. The study draws on data from 1990-2021. The research employs the impulse response analysis and variance decomposition techniques. The study revealed that there is a strong relationship and interaction between FDI, employment, and poverty reduction, highlighting the significant impact of FDI on job creation and poverty alleviation in the ECOWAS region. Policy makers need to consider the inherent time lags in these processes to ensure that policies are appropriately timed when the goals are to generate employment and reduce poverty.
A Comparison of the Intangible Asset Related Standards, IAS38, IVS210 and ISA620 Using Similarity Analysis
Authors: Georgiou Andreas
Published: November 2024

This article attempts to describe the standards dealing with intangible asset treatment by multiple regulatory bodies and subsequently compare them using content and similarity analysis. The specific standards debated are IAS 38 from an accounting perspective, IVS 210 from a valuation perspective, and ISA 620 from an auditing perspective. The similarity analysis is conducted using two tools. First, Voyant tools are used to perform a text similarity analysis of the standards’ text bodies in portable document format. The technique employed is principal component analysis. The second tool is SPSS version 25, which employs various similarity and dissimilarity measures such as simple matching, Jaccard, and Euclidean coefficient, indicating that the similarity of the standards is rather mediocre in relative terms.
Factors shaping situated willingness to communicate: A multidimensional perspective in the Indonesian EFL context
Authors: Amalia Suci Nugrah , Widiati Utami , Rachmajanti Sri , Anugerahwati Mirjam , Waluyo Budi
Published: November 2024

The willingness to communicate (WTC) of English-as-a-foreign-language (EFL) students requires a complicated process, including motivational, contextual, metacognitive, and communicative factors. Neglecting the intricate interplay of these factors may impede the attainment of desired levels of student WTC, thus underscoring the need for comprehensive investigation. The purpose of this exploratory factor analysis (EFA) is to investigate the complex interplay of motivational, contextual, metacognitive, and communicative factors as predictors of situated WTC in the Indonesian EFL context, which includes variables such as motivation, learner agency, growth language mindset, classroom environment, metacognition, communication confidence, and L2 self-perceived communicative competence (SPCC). We used Partial Least Squares-Structural Equation Modeling (PLS-SEM) model analysis in a quantitative study design. An online questionnaire with 50 items adapted from prior studies was distributed to 310 EFL students from multiple universities in Indonesia who had taken English classes. The data revealed that motivation, learner agency, growth language mindset, classroom environment, metacognition, communication confidence, and SPCC are major determinants of students’ WTC. These findings suggest that EFL educators can create language learning programs that encourage active involvement in communication tasks and enhance students’ WTC by recognizing and utilizing the factors that support it. This could lead to more effective and engaging language learning experiences, resulting in increased WTC in the target language. Further discussion focuses on educational consequences and future research recommendations.
Academic vocabulary for L2 argumentative writing: Perspectives from Chinese university EFL learners
Authors: Min Changyong , Sukying Apisak
Published: November 2024

Academic vocabulary plays a critical role in L2 argumentative writing. Recent studies have specifically examined the importance of academic vocabulary and academic word lists for EAP and ESP learning and research. However, it is unclear how English as a Foreign Language (EFL) learners perceive academic vocabulary and the challenges they face using this vocabulary in university argumentative essays. The present study adopted a case study approach to investigate Chinese university EFL learners’ perceptions of, and problems with, academic vocabulary in an argumentative writing task. Five fourth-year advanced EFL learners were assigned to write an IELTS essay before participating in a one-on-one interview. The results indicated that while participants had a heightened awareness of the importance of academic vocabulary, they lacked a comprehensive understanding of this construct. More specifically, they knew little about the academic register, and their academic vocabulary size was small. Consequently, various problems arose in relation to the use of academic words in their argumentative writing, including word choice and the over-reliance on Chinese word meaning and word spelling knowledge. The EFL learners also reported that the biggest challenge to their academic writing was the lack of academic collocation knowledge. These findings have pedagogical implications for understanding the academic lexical problems facing Chinese EFL learners in their academic writing.
Is the throne still for the people? A sociocultural linguistic analysis of Menanam adalah Melawan
Authors: Safrina Raden , Novianti Nita , Rahayu Lina Meilinawati
Published: November 2024

Tahta untuk Rakyat ‘Throne for the People’, which is the principle that the highly respected Hamengkubuwono IX lived by as a democratic and nationalist King of Kesultanan Ngayogyakarta Hadiningrat, embodies the concept of the people, by the people, for the people. Under his rule, Kesultanan Ngayogyakarta Hadiningrat (Yogyakarta Sultanate in Indonesia) was committed to placing the people first. Nevertheless, the book Menanam adalah Melawan, or ‘Planting is Resisting’, challenges the very principle and questions the commitment of the present-day sultanate. The article explores the activist book, which contains the notes of an activist farmer who reflected on and wrote about his journeys and experiences as a farmer-turned-activist after the village where he farmed was claimed by the authorities, including the sultanate, and was planned to be made into a mining site. Fairclough’s sociocultural linguistics frames the analysis, and more specifically through Critical Discourse Analysis (CDA). The results indicate that at the micro level, Widodo’s writing uses emotive and technical language to construct a collective identity of marginalized farmers, opposing powerful entities like the sultanate and corporations. At the meso-level, the text challenges dominant power structures and neoliberal policies, advocating for social justice and a responsive monarchy, while emphasizing the need for transparency and genuine community partnership. The article indicates that the concern about the marginalized should take into account non-mainstream texts such as those produced by the marginalized so that social injustice can be minimized.
Designing the Internal Organization for Circular Economy Innovation: A Knowledge Governance and Microfoundations Approach
Authors: Pascucci Stefano , Ooi Yat Ming , Husted Kenneth
Published: November 2024

Firms implementing circular economy principles in their innovation processes necessitates the redesign of well-established processes and practices. This redesign leverages the various knowledge and practice domains within the firm, at different levels and scales. Despite the importance of knowledge to innovation management, there is a lack of research in innovation studies examining how firms could manage different knowledge flows within the circular economy context. In most research in this area, studies tend to assume that existence of governance mechanisms to manage these knowledge flows. However, given the need for redesigning or introducing entirely new business models to incorporate circularity principles, there is also a need to understand the internal organization that facilitates such changes. In this paper, we conceptualize how organizational mechanisms governing knowledge processes influence firms' adoption of circular-oriented innovation processes. We conclude that firms go through various stages and levels in the adoption process. These levels are linked through situational, action-formation, and transformational mechanisms that govern supportive knowledge processes. We contribute the innovation management literature by linking circular innovation process adoption to knowledge governance and the underlying knowledge processes. Specifically, we highlight the microfoundations nuances of circular-oriented innovation processes adoption that are pertinent to organizing innovation activities within the firm.
Development of a Geoportal for the Integrated Management of Cartographic Information in the Llanganates-Sangay Connectivity Corridor
Authors: Aneloa Wilson Eduardo Chipantashi , Lara Juan Gabriel Mollocana , Mendoza César Iván Álvarez , Herrera Andrea Cecilia Mancheno , Jacho Andy Ronny Lema
Published: November 2024

Objective: The objective of this research was to develop a GeoPortal using the ArcGIS Online platform for the Llanganates-Sangay Connectivity Corridor (CELS) to enhance its management and conservation.   Theoretical Framework: The CELS in Ecuador is a key area for ecological connectivity between two protected areas. Due to its extension across different provinces, the geographic information of the area is dispersed, highlighting the need for a tool that unifies and centralizes these data.   Method: This research adopts a mixed-method approach, integrating qualitative and quantitative data from a Geodatabase with geographic information. Meetings were held with the involved stakeholders to agree on the standards and base layers of the GeoPortal. The created platform was evaluated through surveys conducted with the CELS Research Network and entrepreneurs.   Results and Discussion: The results revealed that the created platform received an approval rating of 4.33 out of 5, indicating a need for better dissemination of the platform's usage and benefits.   Research Implications: The research addresses the efficiency and importance of creating a GeoPortal for managing an ecologically significant area.   Originality/Value: This study contributes to the literature by addressing a problem in an ecologically rich area and providing a solution through the creation of an appropriate tool. The relevance and value of this research are demonstrated in the creation of the GeoPortal and its positive reception.
The status of erythrocyte glutathione in clinical medicine: reality and possibilities
Authors: Alexandrova L. A.
Published: November 2024

The review examines the current state of free radical oxidation processes in clinical medicine. Based on many years of our research and analysis of the literature, we consider the most promising assessment of the activity of glutathione reductase and the level of glutathione reduced in erythrocytes, as a characteristic of the thiol-disulfide redox system of glutathione, not only to indicate oxidative stress, but also a possible prognostic marker of “free radical diseases”.
Jerusalem: Gesichter einer Stadt
Authors: Landmann Lukas
Published: November 2024

Das Erscheinungsbild einer Stadt ist geprägt von den Gebäuden und anderen Spuren, die die jeweilige herrschende Elite im Laufe der Jahrhunderte hinterlassen hat. Zum gemeinsamen Erbe Jerusalems haben Judentum, Christentum und Islam beigetragen. Für alle drei Glaubensrichtungen ist die Stadt ein Ort der Spiritualität; ihr Kampf um die Vorherrschaft ist seit Jahrhunderten eine Konstante, und jede Epoche in der turbulenten Geschichte der Stadt hat eine Facette zu ihrem heutigen Gesicht beigetragen. Die Vielfalt der Zivilisationen und das Mosaik der Traditionen, das erst in seiner Gesamtheit ein umfassendes Bild ergibt, machen das Besondere dieser Stadt aus. Dieses Buch liefert die deutsche Übersetzung zum Bildband Jerusalem: Faces of a City (erschienen auf Englisch, Arabisch und Hebräisch), der das kulturelle Erbe Jerusalems in Bildern und kurzen Texten präsentiert und es in einen historischen Kontext stellt.
Salivary gland duct obstruction after radioiodine therapy: a case report
Authors: Gillani Farkhanda , Imran Muhammad Babar , Naeem Muhammad
Published: November 2024

Background:

Radioiodine therapy has long been used in the treatment of hyperthyroid patients. Salivary complications secondary to radioactive iodine (RAI) treatment are well documented, there is little in the literature addressing salivary gland duct obstruction. We present a rare case of salivary gland duct obstruction developed 2 months after RAI treatment.

Case Presentation:

We describe a 50-year-old male, treated with RAI for hyperthyroidism. He developed pain and swelling in the left submandibular region, 2 months after receiving RAI treatment (25 mCi). His salivary gland scintigraphy was done after injecting 370 MBq (15 mCi) of Tc99m pertechnetate in supine position. It revealed retention of radiotracer in the left submandibular gland with no drainage through the duct system, even on giving lemon stimulus, favoring submandibular gland duct obstruction.

Conclusion:

We report this rare complication of submandibular gland duct injury occurring after RAI therapy. The occurrence of this complication even after low dose of radioiodine administration may be listed in gamut. All necessary measures must be taken to reduce such potential complications.
Genotype–phenotype variability of DARS mutation—case reports of a trio of siblings
Authors: Ong Min Tsui , Willoughby Josh , Connolly Daniel J. A. , Mordekar Santosh , Study DDD , Johnson Diana
Published: November 2024

Background:

We describe a family with hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL), a rare genetic condition causing motor impairment.

Case Presentation:

Whole exome sequencing (DDD study) was performed on the proband who presented with motor symptoms. Sanger sequencing was done on the proband and two affected siblings to validate the result and confirm segregation of the variant with the phenotype. The phenotype and magnetic resonance imaging pattern of the siblings were compared. The index case and her two affected siblings were found to have the same compound heterozygous mutations in the DARS gene. The siblings had milder presentation than previously reported cases, continuing to walk unsupported and have not developed overt spasticity, but have mild upper motor neuron and cerebellar signs. Clinical severity and imaging findings were variable in this family.

Conclusion:

We demonstrated intra-familial variability and very mild symptoms in our family with DARS-associated HBSL, widening the phenotypic spectrum of the condition. It is likely that other factors, genetic and environmental, play a role in this variability.
Renal colic in the emergency department, clinical features, and diagnosis
Authors: Mazi Mazi , Almutairi Atheer , Aldawsari Abdulmajeed , Mubaraki Gehan , Bakr Muneer , Khoofy Ibrahim , Alkharashi Khalid , Alanazi Meshal , Aljohani Mohannad , Almutairi Abdulaziz
Published: November 2024

A study was conducted by reviewing the literature regarding renal colic (RC) in the emergency department (ED) to determine the diagnostic value of the physical examination, patient history, imaging results, and laboratory test, either alone or in conjunction with one another. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was followed in the course of this systematic review investigation. A comprehensive search was performed from 2018 to 2023 using MEDLINE, Google Scholar, and EMBASE to find published English-language studies assessing the diagnostic value of clinical symptoms and signs, clinical examination, imaging, and laboratory investigations for RC diagnosis. The study was limited to adult patients suspected of having RC and presenting with severe pain of unknown cause. It was found that Acupuncture is safe, quick, and significantly less painful than sham acupuncture for patients with RC when combined with an intramuscular injection of diclofenac. A diagnostic approach that excludes ureteric calculi solely based on the lack of hydronephrosis, hematuria, or both might miss a very small number of stones. By using the straightforward and helpful STONE score at the emergency room, patients with RC can avoid needless CT scans in addition to saving money and ionizing radiation exposure. It was concluded that the CHOKAI score performs better in terms of diagnostic performance than the STONE score.
Yerel Hizmet Sunumunda Blok Zinciri Teknolojisi: Şehir Yönetiminde Yenilikçi Yaklaşımlar
Authors: Kurt Zehra
Published: November 2024

Blok zinciri (Blockchain) teknolojisi, ekonomik ve toplumsal yaşamda yakın gelecekte beklenen köklü değişimlerin itici gücü olarak görülmektedir. Bu teknoloji, sadece finans sektöründe değil, aynı zamanda belediyeler gibi kamu kurumlarında da önemli kullanım potansiyeline sahiptir. Belediyelerde blok zinciri kullanımı, şeffaflığı artırarak yolsuzluk riskini azaltabilir, işlemlerin doğrulanmasını hızlandırabilir ve veri güvenliğini artırabilir. Özellikle mülkiyet kayıtları, oy verme sistemleri ve kamu hizmetlerinin yönetimi gibi alanlarda blok zinciri teknolojisi büyük avantajlar sunmaktadır. Yerel hizmetlerin sunumunu yeniden düzenleyip dönüştürebilme kapasitesi nedeniyle de, blok zinciri teknolojisinin belediyelerdeki potansiyel yararları, maliyetleri ve risklerinin değerlendirilmesi önemlidir. Bu çalışmada, kısaca blok zinciri teknolojisinin temel özellikleri ve katkıları anlatılmıştır. Çalışmanın amacı, blok zinciri teknolojisinin belediyelerde uygulanabilirliğini ve potansiyel faydalarını ortaya koymaktır.
Features of foreign investment in business companies that occupy a dominant position in the commodity market
Authors: Milchakova Olesya Vladimirovna
Published: November 2024

The object of the study is certain issues of the procedure for foreign investments in strategic sectors of the economy. The subject of the study is devoted to the procedure for making foreign investments in business entities that occupy a dominant position in the commodity market. The dominant economic entity has market power, which provides an opportunity to shape the economic environment by determining the number of market participants, the behavior of suppliers of goods (works, services) and their consumers. The author examines the issues of necessary regulatory approvals of transactions of foreign investors for the acquisition of assets of dominant entities, as well as general antitrust and special rules for determining the existence of a dominant position in business entities operating in various sectors of the economy. The methodological basis of the study was based on systematic and formal legal methods, as well as the method of technical and legal analysis. The conclusions of the study are based on the constitutionally significant goals of ensuring national defense and state security, Russian legislation provides for the need to obtain additional regulatory approvals for foreign participation in business entities that occupy a dominant position on the market. At the same time, the book value of assets and the amount of revenue of a foreign investor does not matter, a group of persons to which he belongs, as well as a business entity whose assets are planned to be acquired by a foreign investor (a group of persons to which a foreign investor belongs), unlike transactions subject to approval within the framework of antimonopoly control. In some cases, the control of foreign investments applies special rules for determining the fact of market dominance for some business entities, which differ from the rules of antimonopoly legislation.
Association Between Reactive Strength Index During Single-Limb Vertical Continuous Jumps and Isokinetic Knee Extensor Strength Following Anterior Cruciate Ligament Reconstruction
Authors: Hirohata Kenji , Aizawa Junya , Ohmi Takehiro , Ohji Shunsuke , Mitomo Sho , Kawasaki Tomoko , Koga Hideyuki , Yagishita Kazuyoshi
Published: November 2024

OBJECTIVE: To analyze the association between asymmetry in the reactive strength index (RSI) during single-limb vertical continuous jumps (SVCJs) and isokinetic knee extensor strength in athletes who have undergone anterior cruciate ligament reconstruction (ACLR).

DESIGN: Cross-sectional study.

METHODS: This study included 75 athletes (40 female athletes) aged 23.7 ± 8.6 years who had undergone ACLR (mean time from ACLR to measurement: 8.8 ± 4.1 months). The ground contact time and flight time during SVCJs were measured using a force plate, and jump height was calculated from the flight time. The RSI during SVCJs was calculated as follows: RSI = jump height (cm)/contact time (s). The knee extensor strength was measured using an isokinetic dynamometer at 60°/s. The limb symmetry index (LSI) of RSI during SVCJs and knee extensor strength were calculated by dividing the values of the involved and uninvolved limbs. Age, sex, modified Tegner activity scale, and subjective knee function were also recorded. Univariable and multiple regression models were used to assess the association between these and the knee extensor strength.

RESULTS: The involved limb showed significantly lower isokinetic knee extensor strength ( P<0.001, effect size = 0.55) and RSI during SVCJs ( P<0.001, effect size = 0.70) than did the uninvolved limb. In the multiple regression model, only LSI of RSI during SVCJs remained significant (B = 0.440, SE = 0.068, β = 0.604) and accounted for 36.4% of the variance in knee extensor strength recovery ( P<0.001, r2 = 0.364).

CONCLUSION: RSI asymmetry during SVCJs was strongly associated with isokinetic knee extensor strength asymmetry. JOSPT Open 2025;3(2):1-8. Epub 5 November 2024. doi:10.2519/josptopen.2024.0052
Scratching the surface: Unveiling the complex interplay of itch and psoriasis through contemporary research
Authors: Agarwal Netra Chetna
Published: November 2024

The long-lasting presence of itch is an unbearable symptom for people with psoriatic disease, having a profound effect on their quality of life. The itch experience in psoriasis is complex and multifaceted. It is underpinned by neuroimmune interactions, skin barrier dysfunction, and central sensitization pathways. While it has recently been realized that there are neuroimmune interactions in the pathophysiology of itch, tackling chronic itch still proves to be a challenge. The aim of this Perspective Article is two-fold: to assess the novel optimal management strategies for psoriasis-associated itch, while considering the mechanisms of itch in psoriasis and future directions for research.
The prevalence of synovitis during hip arthroscopy for labral tears – An observational study
Authors: Saad Ahmed , Mayne Alistair IW , Iyengar Karthikeyan P. , Wall Peter , Politis Angelos , Bache C. E. , McBryde Callum , Botchu Rajesh
Published: November 2024

Objectives:

Hip pain, secondary to labral tears (LT), can significantly impact the quality of life in the young adult population. LTs can be an incidental finding or can arise from underlying pathology, most commonly from femoroacetabular impingement (FAI). The cause of hip pain in young adults can represent a diagnostic challenge to clinicians. Magnetic resonance imaging (MRI)/magnetic resonance arthrography may be inconclusive in some cases. Therefore, diagnostic hip arthroscopy may be performed to provide a definitive diagnosis and to address intra-articular pathology. During hip arthroscopy, synovitis is often an initial finding. Synovitis can have multiple causes or can also be idiopathic. The aim of this study was to determine the incidence of synovitis detected during hip arthroscopy in patients with an MRI-confirmed LT.

Materials and Methods:

We conducted a prospective review of 50 consecutive patients undergoing hip arthroscopy who had a confirmed LT on MRI. We recorded the presence or absence of synovitis during the initial insertion of the arthroscope. In addition, we recorded demographic data and the grade of LT identified.

Results:

During hip arthroscopy, 31 patients had synovitis present, while 19 did not have synovitis. No significant difference was identified when comparing Visual Analog Score and EQ5D scores between both cohorts.

Conclusion:

Our study found that synovitis is a common finding during hip arthroscopy for FAI syndrome, with 62% of patients with an MRI diagnosis of LT associated with FAI having global hip synovitis present at the time of surgery.
Appraisal of six sigma in pre-analytical phase of clinical biochemistry laboratory
Authors: Parkavi G. , Senghor K. A. Arul , Vinodhini V. M.
Published: November 2024

Objectives:

The aim of the study is to measure the performance of pre-analytical phase of a clinical biochemistry laboratory using sigma metrics and the six sigma scale.

Materials and Methods:

The study included documented data of blood sample rejection from March 2023 to February 2024 and follow-up data from March 2024 to August 2024. International Federation of Clinical Chemistry and Laboratory Medicine developed Quality Indicators (QIs) used are QI-9 Wrong tubes; QI-10 Hemolyzed samples; QI-11 Clotted samples; QI-12 Insufficient samples; QI-14 Damaged samples in transport; and QI-15 Mislabeled samples. Based on “Six Sigma Quality Design and Control” established by Dr. Westgard, the sigma metric was calculated for the above-mentioned QIs.

Statistical analysis:

Obtained data were entered and analyzed using Microsoft Excel 2021.

Results:

Out of 162,380 received samples, 547 samples were rejected as not satisfied with the sample acceptance criteria. The most common pre-analytical error in the observed QIs is hemolyzed samples (458), followed by insufficient sample volume (55). The Sigma score of QI-10 was determined to be 4.81, whereas QI-9, QI-11, QI-12, and QI-15 were well maintained and graded excellent. Following training sessions, the follow-up month revealed a sigma score of 4.98 for QI-10.

Conclusions:

Six sigma metrics are a competent means to measure the performance of pre-analytical QIs in a clinical biochemistry laboratory. The observed QIs were effectively managed (>4 σ).
Neglected perilunate injuries: Management strategies and long-term consequences: A narrative review
Authors: Jerome J. Terrence Jose
Published: November 2024

Neglected perilunate injuries are a challenging and often overlooked condition that can result in significant long-term consequences if not properly managed. These injuries, typically resulting from high-energy trauma, involve dislocations and fractures around the lunate bone, with delayed diagnosis leading to complex management scenarios. This narrative review examines the management strategies for neglected perilunate injuries and the associated long-term outcomes. The review explores the efficacy of different surgical approaches, including open reduction and internal fixation, proximal row carpectomy, wrist fusion, and bone retinacular bone graft scapholunate reconstruction. By evaluating the existing literature, this article highlights the critical need for early diagnosis and appropriate intervention to minimize the risk of post-traumatic arthritis and other degenerative changes.
Genetic diagnosis in XY disorders of sex development
Authors: Priyadarshini Sukanya , Sharma Rajni , Jain Vandana
Published: November 2024

XY disorders of sex development (XY DSD) comprise a class of heterogeneous genetic entities that result in discrepancies between chromosomal, gonadal, and phenotypic sex due to a reduction in androgen synthesis or action. The chief categories of disorders include gonadal dysgenesis, disorders with reduced androgen production (biosynthetic defect – either alone or in conjunction with impaired glucocorticoid and/or mineralocorticoid synthesis), and insensitivity to androgen action. While conventional diagnostic modalities, encompassing karyotyping, biochemistry, radiology, and, in a few cases, diagnostic laparoscopy, help in formulating a provisional diagnosis, molecular genetic testing is key to arriving at a precise etiology. Besides ending the diagnostic uncertainty, a molecular diagnosis helps to predict the natural course in terms of pubertal development and potential for fertility, thus contributing to decisions on the gender of rearing; and guides on surveillance for extragenital features and the risk of recurrence in subsequent pregnancies. This paper broadly discusses the genetic basis of XY DSD, different modalities of genetic testing, and their utility and limitations.
Manajemen Program Pengenalan Makanan Khas Daerah Sebagai Media Internalisasi Nilai Pancasila Dalam Kurikulum Merdeka di TK Kelurahan Sokanegra
Authors: Wijayanti Catur Menik , Ardy Wiyani Novan
Published: November 2024

Pengenalan budaya kepada anak memberikan edukasi tentang keberagaman budaya yang harus saling dihargai sehingga norma dan nilai budaya bangsa akan dapat terwariskan pada generasi selanjutnya .Projek Penguatan Profil Pelajar Pancasila hadir untuk menuangkan visi pemerintah terhadap hasil pendidikan, menunjukkan karakter dan kompetensi yang diharapkan dimiliki murid sepanjang dan setelah selesai pembelajaran di satuan pendidikan. Penelitian ini merupakan jenis penelitian deskriptif menggunakan pendekatan penelitian kualitatif.Teknik pengumpulan data pada penelitian ini adalah dengan wawancara,observasi dan dokumentasi.Untuk mendapatkan data yang valid, peneliti melakukan triangulasi data . Program pengenalan makanan khas daerah sebagai media internalisasi nilai Pancasila bertujuan untuk menghargai kebhinekaan.Makanan daerah tradisional memiliki peran penting dalam budaya Indonesia. Dalam nilai Pancasila terkandung bahwa Pancasila mengajarkan kita untuk menghargai perbedaan, termasuk dalam hal ini salah satunya makanan khas daerah. Materi dalam program ini diawali dengan melihat vidio pembutan gethuk untuk memvisualisasikan cara membuat gethuk. Setelahnya siswa akan dikenalkan dengan bahan dasar membuat gethuk yaitu singkong. Manejemen program pengenalan makanan khas daerah dapat dijadiakn sebagai media internalisasi nilai- nilai Pancasila dalam kurikulum merdeka yang cukup efektif. Karena dalam pengenalan makanan khas daerah bisa dijadikan sarana untuk mengenalkan keragaman budaya dan nilai- nilai yang terkandung dalam masyarakat setempat.
 
Kata Kunci: manajemen, makanan, Pancasila