bluuebunny/crossref_metadata_2025 huggingface dataset:
Le Goff, History And Memory
Authors: Frey Linda
Published: April 2024

According to the Greeks, the goddess Mnemosyne, the personification of memory, gave birth to the muses after sleeping with Zeus. Jacques Le Goff explores the relationship between the goddess and one of her muse offspring, Clio, in this thought-provoking work on the historian's craft. A leading member of the Annales school, Jacques Le Goff demonstrates the tools of the school that has so revolutionized historical studies. Steven Randall and Elizabeth Claman have selected and translated four of ten articles that appeared a decade ago in Italian translation in the Enciclopedia and later separately as Storia e Memoria. These texts focus on Past/Present, Antique/Modern, Memory, and History.
A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol
Authors: Bullock Laurna , Nicholls Elaine , Cherrington Andrea , Butler-Walley Stephanie , Clark Emma M , Fleming Jane , Leyland Sarah , Bentley Ida , Thomas Simon , Iglesias-Urrutia Cynthia P , Webb David , Smith Jo , Bathers Sarah , Lewis Sarah , Clifford Angela , Siciliano Michele , Protheroe Joanne , Ryan Sarah , Lefroy Janet , Dale Nicky , Hawarden Ashley , Connacher Sarah , Horne Robert , O'Neill Terence W , Mallen Christian D , Jinks Clare , Paskins Zoe
Published: April 2024

Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and values. We developed the improving uptake of Fracture Prevention drug treatments (iFraP) intervention comprising a computerised Decision Support Tool (DST), clinician training package and information resources, for use in UK Fracture Liaison Service consultations. Two primary objectives to determine (1) the effect of the iFraP intervention on patient-reported ease in decision-making about osteoporosis medicines, and (2) cost-effectiveness of iFraP intervention compared to usual NHS care. Secondary objectives are to determine the iFraP intervention effect on patient reported outcome and experience measures, clinical effectiveness (osteoporosis medicine adherence), and to explore intervention acceptability, mechanisms, and processes underlying observed effects, and intervention implementation. Methods The iFraP trial is a pragmatic, parallel-group, individual randomised controlled trial in patients referred to a Fracture Liaison Service, with nested mixed methods process evaluation and health economic analysis. Participants aged ≥50 years (n=380) are randomised (1:1 ratio) to one of two arms: (1) iFraP intervention (iFraP-i) or (2) comparator usual NHS care (iFraP-u) and are followed up at 2-weeks and 3-months. The primary outcome is ease of decision-making assessed 2 weeks after the consultation using the Decisional Conflict Scale (DCS). The primary objectives will be addressed by comparing the mean DCS score in each trial arm (using analysis of covariance) for patients given an osteoporosis medicine recommendation, alongside a within-trial cost-effectiveness and value of information (VoI) analysis. Process evaluation data collection includes consultation recordings, semi-structured interviews, and DST analytics. Discussion The iFraP trial will answer important questions about the effectiveness of the new ‘iFraP’ osteoporosis DST, coupled with clinician training, on SDM and informed initiation of osteoporosis medicines. Trial registration: ISRCTN 10606407, 21/11/2022 https://doi.org/10.1186/ISRCTN10606407
Improved Method for Determining the Feed Influence on the Tangential Cutting Force During Re-drilling, Countersinking and Boring Based on the Small Sample Theory
Authors: Krupa Volodymyr , Kobelnyk Volodymyr , Hahaliuk Andrii , Dzyura Volodymyr , Tymoshenko Nadiia
Published: April 2024

Methods of determining the tangential cutting force are analyzed in the work, including finite-element simulation models, the use of neural networks, analytical methods, and methods of natural experiments. A method for evaluating the influence of feed on the tangential component of the cutting force is proposed, which can be applied to test new tools, tool plates for a certain group of materials. The main advantage of the proposed method is the limited number of experiments and processing of the obtained data according to the theory of a small sample. In this study, the proposed method was used to determine the influence of countersinking feed on tangential cutting force. The basis of the approach is probabilistic and statistical methods and data processing criteria. An assessment of the homogeneity of the results of experimental studies was carried out, the law of distribution of the tangential cutting force, as well as the characteristics of its dispersion, were established. An approach to estimating the maximum value of the tangential component of the cutting force based on the maximum value is presented. This method is universal and can be used for drilling, countersinking, boring and other types of processing.
NAVIGATING LEGAL FRONTIERS: ADDRESSING CHALLENGES IN REGULATING THE DIGITAL ECONOMY
Authors: Dalipi Liridon , Zuzaku Agim
Published: April 2024

Background: The integration of digital technologies into various facets of society has given rise to the digital economy, transforming the economic landscape. Western Balkan nations face challenges from this digital transformation, necessitating effective regulatory frameworks. Recognising and addressing regulatory gaps is crucial for fostering a secure and innovative digital environment. This study examines regulatory challenges in the Western Balkans' digital economy, focusing on public-private partnerships (PPPs) in cybersecurity. The research question revolves around identifying gaps in legal frameworks, understanding PPP dynamics in countering cyber threats, and assessing the potential impact of the EU's Digital Market Act and Digital Services Act on the Western Balkan regulatory sphere.
Methods: The research employs a qualitative approach, analysing the legal and policy frameworks of six Western Balkan countries. Data is gathered through an in-depth examination of cybersecurity laws, strategies, and action plans, with a specific emphasis on provisions related to PPPs. Comparative analysis is utilised to discern patterns and variations across the countries while also considering the potential impact of the Digital Market Act and Digital Services Act.
Results and conclusions: The analysis reveals a common challenge – the lack of specific regulations for the digital economy, creating a legal vacuum. Varying PPP integration levels exist across the Western Balkans. Significant findings include ethical considerations, challenges related to data privacy, and the need for robust competition regulations. Examination of the Digital Market Act and Digital Services Act highlights potential harmonisation opportunities and challenges. In conclusion, the research underscores the urgency for comprehensive regulatory reforms in the Western Balkans to address the challenges of the digital economy. The study advocates for developing specific laws governing digital platforms, strengthening PPPs to enhance cybersecurity, and incorporating ethical considerations in legal frameworks. The findings offer valuable insights for policymakers and stakeholders, emphasising the necessity of adaptive and forward-looking regulatory approaches in the ever-evolving digital landscape, considering the potential impact of EU initiatives such as the Digital Market Act and Digital Services Act.
RECOGNITION AND ENFORCEMENT OF FOREIGN COURT DECISIONS IN THE CASE LAW OF THE CONSTITUTIONAL COURT OF REPUBLIC OF KOSOVO
Authors: Shahiqi Din
Published: April 2024

Background: To respect international cooperation, human rights and legal certainty, it is possible to recognise the legal effects of foreign judicial decisions in another state, provided that the procedure for recognising a foreign judicial decision takes place and that such court decision fulfils the requirements set by local legislation. Recognition, as a concept, entails acknowledging the rights and obligations established in the originating jurisdictions and accepting juridical consequences. Enforcement, on the other hand, means fulfilling the obligation, allowing the creditor to realise his/her right and to ensure that the debtor has obligations and obeys the decisions that have already been made. International collaboration should facilitate the codification of Kosovo's legal framework on private international law, allowing for the recognition and enforcement of foreign decisions to be less complicated, more extensive, and more easily applicable. In comparison to prior solutions, the new law makes significant adjustments. Previous norms are being abandoned in favour of open links and jurisdictional criteria. Some prior solutions are preserved and, if necessary, changed and improved.
Methods: The doctrinal approach involves the systematic identification, collection, and application of legal literature within the domain, encompassing statutes, texts, articles, and scholarly research by both local and international authorities. Additionally, the method involves a meticulous analysis of judicial practices, evaluating the practical implementation of legal standards and their judicial interpretations. Through examining legislation, our approach not only identifies legal issues but also furnishes a scholarly interpretation of the laws governing the field of study and its related institutions.
Results and conclusions: Kosovo, as a relatively new state, has established a legislative framework through which it attempts to address problems and the path that must be taken in the implementation of foreign judgments. In general, the goal of having a democratic and well-developed society also means respecting the rights and decisions of foreign citizens, the rights that originate from the judicial decisions of international courts and the internationally accepted conventions. The harmonisation of the legislation and its compliance with ECHR conventions creates real opportunities for Kosovo to be ranked among the countries that respect these decisions. The legal system of Kosovo, as well as decisions made by the Constitutional Court, have produced results that can be used to influence future cases. The codification of private international law in Kosovo means that numerous circumstances will now have a legal basis for implementing foreign decisions.
Pengembangan Paltform Layanan Konsultasi Kecantikan Online Untuk Meningkatkan Industri Ekonomi Digital Kreatif di Indonesia
Authors: Rosita Putri Aulia , Nuryananda Praja Firdaus
Published: April 2024

The platform business model is a simple yet powerful concept that radically alters business, the financial system, and society in general. The platform revolution threatens almost all industries that rely heavily on information. This concept evolved into a view of the interdependence of innovation and technological advancement, which influences both macro and microeconomics. whomever decides how far digital technology can travel. The MBKM initiative exists to strengthen the creative digital economy in Indonesia, and one of the outcomes of this study was the creation of an online beauty consultation service platform.
Inovasi Mahasiswa Kampus Mengajar Dalam Meningkatkan Efektivitas Pembelajaran SDN Cihaur
Authors: Ardi Afriansyah
Published: April 2024

The Covid-19 pandemic has had a significant impact on the education sector, forcing a change from conventional learning to online learning. This situation is a special challenge for elementary school teachers who are used to face-to-face learning. This article discusses the Class 1 Teaching Campus Program as the Indonesian government's response to improving the quality of education in the midst of the pandemic. This program involves students in providing teaching assistance in elementary schools in various regions. The main focus is to develop students' interpersonal and technical skills and make a positive contribution to the learning process in elementary schools. The program implementation method involves preparation, implementation, observation, and design. In the teaching stage, students succeeded in increasing students' motivation and interest in learning, while teachers and schools found it easy to implement online and offline learning. This program has also succeeded in adapting technology to support learning, including the use of laptops and MS Excel applications. The evaluation results show a positive impact on students' abilities and ease of learning management for teachers. The Batch 1 Teaching Campus Program at Cihaur State Elementary School, Sukabumi Regency, West Java, can be considered successful in increasing the effectiveness of learning during the pandemic emergency. Increasing student interest in learning and adapting technology are important points in dealing with sudden changes in the learning system. This program creates positive integration of values ​​in the social and educational system in Cihaur Village. Therefore, it is important to implement this kind of collaborative activity widely to support improving the quality of education in the future.
Peningkatan Pengetahuan Akuntansi Dasar pada Guru-guru SMK Sumatra 40 Bandung
Authors: Bayunitri Bunga Indah , Brata Ignatius Oki Dewa , Laksono Roosaleh , Heru Yogo , Gunanta Remon , Gusnandar Sendi
Published: April 2024

Community service activities for Teachers at Vocational School Sumatra 40 Bandung aim to optimize teachers who want to update their Basic Accounting Knowledge. It also helps to improve their basic accounting skills by expanding the marketing they gain after understanding basic accounting knowledge. The role of Basic Accounting Knowledge today is not only the ability to calculate, record, and make financial reports but also to provide new understanding and knowledge that students need. It is hoped that students will gain new knowledge that can be applied in the world of work so as to produce more competitive graduates. At the start of updating Basic Accounting knowledge, a solution is needed to resolve a series of problems, namely training in basic Accounting Knowledge, such as understanding the philosophy of assets, liabilities, and equity. From these three materials, it is hoped that you will have a good mastery of assets, liabilities, and equity. This update is also needed to be transferred to students facing accounting problems they will encounter in the world of work. As a result of this activity, the teachers at SMK Sumatra 40 Bandung have implemented financial management in every unit in the school, which becomes an example of implementation for their students.
Evaluasi Pemborosoan Mesin Bending Berbasis Pendekatan Statistical Process Control dan Overall Equipment Effectivenes
Authors: Muzakki Ahmad Syahri , Negoro Yanuar Pandu , Hidayat Hidayat
Published: April 2024

PT. ASM merupakan sebuah perusahaan yang beroperasi di sektor baja. Dalam produksi tentulah penting menjaga produktifitas pada mesin untuk tetap menjaga performa kualitas produksi. Di penelitian ditemukan masalah berupa kerusakan mesin yang mengakibatkan berhentinya produksi. Dalam penelitian ini Metode Statistical Quality Control (SQC) diterapkan sebagai pendekatan manajemen mutu untuk mengontrol proses dan kualitas produk dengan mengintegrasikan Overall Equipment Effectiveness (OEE) dan SQC. Dalam penelitian, terdapat dua jenis data, yaitu data primer dan data sekunder yang digunakan sebagai referensi untuk memudahkan proses penyelesaian masalah. Data primer diperoleh melalui wawancara terkait proses produksi, fungsi mesin, dan penyebab kecacatan dalam produksi, sedangkan data sekunder diperoleh dari rekapan data perusahaan terkait defect dalam produksi. Berdasarkan hasil diagram Pareto, ditemukan bahwa sebesar 55% dari permasalahan adalah tidak presisi, sementara 45% disebabkan oleh besi retak selama proses produksi. Dengan demikian, dapat disimpulkan bahwa cacat produk terutama disebabkan oleh retakan pada besi dan ketidak presisian pada mesin
A Note on the Impact of the Canada-India Diplomatic Standoff on the Performance of Canadian Mutual Funds Investments in India
Authors: Pratima F N U , Nippani Srinivas , Phan Hanh
Published: April 2024

On June 18, 2023, Mr. Hardeep Singh Nijjar, a Canadian citizen of Indian origin, was killed in Canada. On September 18, 2023, the Canadian Prime Minister, Mr. Justin Trudeau, accused the Indian Government of involvement in killing Mr. Nijjar in the Canadian Parliament. This accusation preceded and succeeded by other events, led to a significant diplomatic standoff that is still ongoing. We examine the impact of this event chain on the performance of daily returns of mutual funds based in Canada that are predominantly invested in Indian securities. Our results, controlled for general stock market returns, fund size, expense ratio, and interest rates, indicate that the events negatively impacted fund performance. Our study adds to the existing literature on the benefits of international diversification of mutual funds in disconnected markets. The findings of this paper suggest that political discord between two distinct and unrelated economies may impact profits and negate the advantages of international diversification. Our study is significant to professionals, particularly mutual fund managers, as it demonstrates the role of two countries’ political ties in affecting mutual fund returns.
What Determines Global Flows of Entrepreneurial Finance?
Authors: Hall Thomas
Published: April 2024

Economists examine foreign direct investment, which mostly constitutes flows to established firms (sometimes characterized as “multinational corporations”) that might or might not engage in truly innovative activity in the FDI target country. Conversely, finance scholars have studied the pipeline of entrepreneurial finance from limited partnerships (LPs) to venture capitalists (VCs) or private equity general partners (GPs) to portfolio firms. Few studies examine relationships between general and limited partners, and those that do often examine only the United States, or a limited number of countries in a given region. This paper uses a novel dataset (LP Source) to examine secular trends in cross-national flows from the LP to the GP (in the form of various investment funds) to the portfolio firm. We find evidence for “home bias” and demonstrate that cross-border flows are affected by GDP per capita, export orientation, and country-level measures of the entrepreneurial environment.
Protecting Intellectual Property in International Expansion: Preparing an Innovation-Based SME
Authors: Eghbali-Zarch Majid , Patel Mohamed Zain
Published: April 2024

A key concern among innovation-based SMEs is to protect their intellectual property (IP) as they grow internationally. To explore the challenges such resource-constrained firms face, we conducted action research at a technology-based SME that aspired to expand internationally. Through collaborative and periodic interventions, we sought to help managers of the organization work around the issues that surfaced while preparing to internationalize further. Our collaboration led us to examine isolating mechanisms, such as rapid international expansion, that the SME could deploy to pre-empt competitive imitation of their innovative products and processes, especially as their IP is not protected legally (e.g., by patents). Results point to inevitable identified tensions and paradoxes, leading us to approaches and practices the firm can adopt.
Bioética e a eutanásia por conveniência de cães e gatos
Authors: Bastos Paula Andrea de Santis , Cohen Cláudio
Published: April 2024

O objetivo foi discutir as justificativas para a realização da eutanásia por conveniência, de cães e gatos domésticos, segundo as abordagens normativa e bioética. Eutanásia por conveniência é aquela realizada sem o animal apresentar uma condição clínica que respalde tal procedimento. Aquela que ocorre por questões financeiras, mudanças nas circunstâncias pessoais, tempo escasso para os cuidados do animal, sensação de incapacidade ou falta de vontade de cuidar do animal. O aumento de procedimentos que vem sendo disponibilizados na medicina veterinária levam ao impasse de custos muito elevados de tratamento. No Brasil, deve-se considerar que por existir, na área humana, tratamentos dispendiosos financeiramente amparados pelo Sistema Único de Saúde (SUS), ou pela Saúde Suplementar, a população fica sem referência dos valores dos procedimentos de saúde. A realização da eutanásia é contribuinte determinante para o risco de suicídio e sofrimento psicológico em veterinários. Destaca-se que a cultura e a religião podem influenciar significativamente as atitudes em relação à eutanásia e à morte. Portanto, seja do ponto de vista do valor (ética) ou do ponto de vista religioso, médicos veterinários e tutores podem não concordar com a prática da eutanásia e isso tem que ser respeitado. A eutanásia por conveniência de cães e gatos é um tema para a bioética se debruçar, pois envolve interesses inerentes ao animal, ao tutor e ao médico veterinário. No Brasil, a eutanásia por conveniência não está normativamente amparada e, bioeticamente, ela é pouco discutida.
PENERAPAN METODE DESIGN THINKING PADA PERANCANGAN STOK FOTO PROGRAM STUDI DESAIN KOMUNIKASI VISUAL UNIVERSITAS DIAN NUSWANTORO KEDIRI
Authors: Setyanto Daniar Wikan , Yanuarsari Dzuha Hening , Gardianto Gilang Rizky
Published: April 2024

AbstrakUniversitas Dian Nuswantoro (Udinus) merupakan perguruan tinggi terakreditasi Unggul yang berdomisili pada beberapa kota yakni Semarang, Kediri dan Lombok. Udinus memiliki kampus utama di Semarang terdiri dari 6 Fakultas dan 23 Program Studi. Udinus juga memiliki Program Studi Di Luar Kampus Utama (PSDKU) yang salah satunya sudah beroperasi yakni di Kediri. Kendala yang dihadapi pada kampus PSDKU Udinus Kediri tersebut adalah belum memiliki stok foto yang bisa digunakan untuk publikasi dan promosi bagi program studi Desain Komunikasi Visual (DKV). Media publikasi dan promosi merupakan sesuatu yang vital untuk Udinus sebagai sebuah Perguruan Tinggi Swasta.  Beberapa platform aplikasi yang digunakan Udinus dalam publikasi dan promosi saat ini yakni ada pada instagram dan brosur. Mempertimbangkan dari cakupan promosi yang dilakukan Udinus ke depan akan semakin luas maka diperlukan adanya perancangan stok foto yang dapat dimanfaatkan untuk kebutuhan publikasi dan promosi. Tujuan penelitian ini yakni merancang stok foto untuk Udinus Kediri dengan menggunakan penerapan metode Design Thinking dari Bryan Lawson dan Nigel Cross. Penelitian ini menghasilkan stok foto yang original sesuai dengan kebutuhan publikasi dan promosi program studi Desain Komunikasi Visual Udinus Kediri. Kata Kunci: design thinking, promosi, publikasi, stok foto, Udinus AbstractDian Nuswantoro University (Udinus) is an accredited superior university which is domiciled in several cities, namely Semarang, Kediri and Lombok. Udinus main campus in Semarang consists of 6 faculties and 23 study programs. Udinus also has a Study Program Outside the Main Campus or called PSDKU which is now operating in Kediri. The obstacle faced at the PSDKU Udinus Kediri campus is that it does not yet have stock photos that can be used for publication and promotion for the Visual Communication Design (DKV) study program. Publication and promotional media are vital for Udinus as a private university. Some of the application platforms that Udinus currently uses in publications and promotions are Instagram and brochures. Considering that the scope of promotions carried out by Udinus in the future will become wider, it is necessary to design stock photos that can be used for publication and promotional needs. The aim of this research is to design stock photos for Udinus Kediri using the Design Thinking method of Bryan Lawson and Nigel Cross. This research produces original stock photos in accordance with the publication and promotion needs of the Udinus Kediri Visual Communication Design study program. Keywords: design thinking, promotion, publication, stock photos, Udinus
REPRESENTATION OF CUSTOMER LOYALTY IN AQUA’s ADVERTISEMENT “SAMBUT KEBAIKAN RAMADHAN BERSAMA AQUA”
Authors: Karim Iklilul , Utari Prahastiwi , Hasjarjo Sri
Published: April 2024

Abstract. Relize or not, advertising is very close to human life. Mass media can display tens or even hundreds of advertisements every day. Therefore, effective and attractive advertisements are needed to attract customers. In general, advertising uses the hard selling method, but now it has turned into soft selling, which does not introduce or sell products directly. Therefore, this research will discuss the representation of customer loyalty in AQUA's advertisement "Sambut Kebaikan Ramadan Bersama AQUA". The method used is qualitative with Roland Barthes semiotic analysis. The results of this study show that AQUA's advertisement "Sambut Kebaikan Ramadan Bersama AQUA'' successfully portrays customer loyalty through the usage of strong signs and hidden meanings. At the denotative level, this AQUA advertisement presents an image of loyal AQUA customers who consume AQUA products joyfully during Ramadan. At the connotative level, this advertisement connects the usage of AQUA products with the values of kindness, spirituality, and brotherhood associated with Ramadan. At the mythological level, this AQUA advertisement builds a narrative that describes AQUA’s customers as part of a solid and loving community. In this context, customer loyalty is represented as a form of adherence to the values embraced by the community, which is signified by the consumption of AQUA’s products.Keywords: Advertisement, Representation, Loyalty, Semiotic
From private dialect to public language: Transforming Moroccan Arabic through the voices of sub-Saharan African immigrants
Authors: Hickman Kristin Gee
Published: April 2024

Over the past few decades, Morocco has witnessed a surge of activity related to colloquial Moroccan Arabic, or Darija ( dārija), a vernacular variety of Arabic that is unstandardized and officially unrecognized. Darija has become increasingly present in domains that were previously reserved for standard Arabic ( fuṣḥā), and there has been a tangible shift in how Moroccans think about their “mother tongue.” Largely unremarked, though, is the fact that this linguistic shift has coincided with another major transition: the transformation of Morocco from a “sender” country to a “receiver” country, i.e., from a mere transit point for irregular Mediterranean migration to a sought-after destination for cosmopolitan African immigration. This article investigates the intersection of these two shifts by looking at the use of Darija by sub-Saharan African immigrants in Morocco. Based on fieldwork in two urban centers, Casablanca and Tetouan, it argues that Darija has become a key site for sub-Saharan African immigrants to negotiate their place in Moroccan society. It also argues that their growing audibility in the Moroccan soundscape is challenging commonplace assumptions about the limited and provincial nature of Darija. Ultimately, I contend that Darija is transitioning toward what Woolard (2016) has called a public language, and that this shift is due not only to Moroccan language activists but also to sub-Saharan African immigrants.
Enhancing the Efficacy of CAR-T Cell Therapy: A Comprehensive Exploration of Cellular Strategies and Molecular Dynamics
Authors: Baysal Mehmet A. , Chakraborty Abhijit , Tsimberidou Apostolia M.
Published: April 2024

The emergence of chimeric antigen receptor T cell (CAR-T cell) therapy has revolutionized cancer treatment, particularly for hematologic malignancies. This commentary discusses developments in CAR-T cell therapy, focusing on the molecular mechanisms governing T cell fate and differentiation. Transcriptional and epigenetic factors play a pivotal role in determining the specificity, effectiveness, and durability of CAR-T cell therapy. Understanding these mechanisms is crucial to improve the efficacy and decrease the adverse events associated with CAR-T cell therapies, unlocking the full potential of these approaches. T cell differentiation in CAR-T cell product manufacturing plays an important role in clinical outcomes. A positive correlation exists between the clinical efficacy of CAR-T cell therapy and signatures of memory, whereas a negative correlation has been observed with signatures of effector function or exhaustion. The effectiveness of CAR-T cell products is likely influenced by T-cell frequency and by their ability to proliferate, which is closely linked to early T cell differentiation. The differentiation process involving distinct T memory cell subsets is initiated upon antigen elimination, indicating infection resolution. In chronic infections or cancer, T cells may undergo exhaustion, marked by continuous inhibitory receptor expression, decreased cytokine production, and diminished proliferative capacity. Other cell subsets, such as CD4+ T cells, innate-like T lymphocytes, NKT cells, and cord blood-derived hematopoietic stem cells, offer unique advantages in developing the next-generation CAR-T cell-based therapies. Future research should focus on optimizing T-cell-enhancing approaches and developing strategies to potentially cure patients with hematological diseases and solid tumors.
Impact Of Academic Supervision on Improving Performance of Early Childhood Education Teachers in Early Age Learning
Authors: Sum Theresia Alviani , Bora Ignatius Febriyanto R
Published: April 2024

This research aims to understand and describe the implementation of academic supervision by school principals; assess the performance of Early Childhood Education (PAUD) teachers; determine the influence of academic supervision on PAUD teacher performance; and identify the impact of academic supervision implementation on PAUD teacher performance. This study employed an ex-post facto correlational research design. The population consisted of 594 respondents from various PAUD institutions, with a sample size of 44 respondents selected using Stratified Random Sampling based on the accreditation status of the PAUD institutions. Data were collected through non-test methods, including questionnaires validated using Likert scales and Cronbach's Alpha reliability test, interviews, observations, and documentation. Instrument content validity was 0.89 < 0.75, and reliability was 0.815 < 0.6. Data analysis involved parametric statistical analysis and Spearman correlation tests.

The findings revealed: 1) Academic supervision by school principals in Manggarai Raya was implemented with a percentage of 40% for accreditation A, indicating excellent performance. However, when viewed comprehensively, it was considered low or unsatisfactory due to being below 50%; 2) PAUD teacher performance in Manggarai Raya, assessed using all indicators, fell into the very good category with a percentage of 20%. Yet, when viewed holistically, it was deemed inadequate/poor as it was below 50%; 3) There was a positive influence of academic supervision by school principals on PAUD teacher performance in Manggarai Raya, with a Cohen's value of 0.99, indicating that 99% of the variance in teacher performance was influenced by academic supervision by school principals; 4) The contribution of academic supervision to PAUD teacher performance in Manggarai Raya, assessed using an R2 coefficient, was 0.27% or 27%; and 5) There was an impact of academic supervision on PAUD teacher performance.

Keywords: academic supervision, PAUD teacher performance
Effectiveness Of Digital Text in Interactive Library for English Starters (Digi-Tiles in Enhancing The Reading Comprehension Of Grade 3 Learners)
Authors: Laroza Jujie
Published: April 2024

This quasi-experimental study was conducted to measure the effectiveness of Digital Text in Interactive Library for English Starters (Digi-TILES), which is a digital learning tool, in improving the reading comprehension level of Grade 3 pupils of Sampiruhan Elementary School. The intervention tool was designed to develop reading comprehension of learners and results were measured through comparing pretest and post-test scores.Two (2) paired groups of learners participated in the study composed of 30 members for each group. Each groupÃ¢â‚¬â„¢s reading comprehension level was determined through standardized Phil-IRI materials. The digital tool intervention developed by the researcher was utilized by the experimental group while the comparison group utilized plain printed Pivot Self Learning Modules distributed by Department of Education. Paired and Independent Samples T-tests were used to answer the inferential questions of the study.The experimental group, after utilizing the intervention tool scored higher in their post-test than the comparison group. Comparing also the pretest and post-test of the experimental group, it is notable that the scores in the latter are significantly higher. This implies that the Digi-TILES learning tool has impacted the learnersÃ¢â‚¬â„¢ reading comprehension positively.The hypotheses stating that there is no significant difference between the post-test of the two groups were rejected. The findings therefore reflect that the experimental group scored higher those in the comparison group. The Digi-TILES therefore helped in enhancing the reading comprehension of Grade 3 learners. It is therefore suggested that the school may consider utilizing this tool to improve the quality of learners when it comes to reading comprehension.
The materiality key: how work on empirical data can improve analytical models and theoretical frameworks for multimodal discourse analysis
Authors: Maiorani Arianna
Published: April 2024

This article is a critical reflection on the way the notion of materiality informed the project and the development of The Kinesemiotic Body project carried out by a UK and German research teams and of the model of analysis it adopted, the Functional Grammar of Dance. It starts with an excursus of some of the most interesting developments in other discipline that turned to the investigation of materiality as an epistemological perspective, and it shows how the same type of focus has impacted on multimodal discourse analysis focusing on movement-based communication. The overarching theme that characterises this multidisciplinary attention to materiality is its anchoring function to the temporal and spatial coordinates in which social phenomena are contextualised, which is taken as the fundamental condition for shaping our perception and understanding of the world in all areas of experience and knowledge. A more specific example of how the notion of materiality impacted on the development of movement-based discourse analysis will be provided by an example of analysis of rich movement data captured live from professional dancers from the English National Ballet.
Differential impact of fentanyl and morphine doses on ticagrelor-induced platelet inhibition in ST-segment elevation myocardial infarction: a subgroup analysis from the PERSEUS randomized trial
Authors: Garin Dorian , Degrauwe Sophie , Carbone Federico , Musayeb Yazan , Lauriers Nathalie , Valgimigli Marco , Iglesias Juan F.
Published: April 2024

Introduction

Among patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI), intravenous fentanyl does not enhance ticagrelor-induced platelet inhibition within 2 h compared to morphine. The impact of the total dose of fentanyl and morphine received on ticagrelor pharmacodynamic and pharmacokinetic responses in patients with STEMI remains however undetermined.

Materials and methods

We performed a post-hoc subanalysis of the prospective, open-label, single-center, randomized PERSEUS trial (NCT02531165) that compared treatment with intravenous fentanyl vs. morphine among symptomatic patients with STEMI treated with primary PCI after ticagrelor pretreatment. Patients from the same population as PERSEUS were further stratified according to the total dose of intravenous opioids received. The primary outcome was platelet reactivity using P2Y12 reaction units (PRU) at 2 h following administration of a loading dose (LD) of ticagrelor. Secondary outcomes were platelet reactivity and peak plasma levels of ticagrelor and AR-C124910XX, its active metabolite, at up to 12 h after ticagrelor LD administration. Generalized linear models for repeated measures were built to determine the relationship between raw and weight-weighted doses of fentanyl and morphine.

Results

38 patients with STEMI were included between December 18, 2015, and June 22, 2017. Baseline clinical and procedural characteristics were similar between low- and high-dose opioid subgroups. At 2 h, there was a significant correlation between PRU and both raw [regression coefficient (B), 0.51; 95% confidence interval (CI), 0.02–0.99; p = 0.043] and weight-weighted (B, 0.54; 95% CI, 0.49–0.59; p < 0.001) doses of fentanyl, but not morphine. Median PRU at 2 h was significantly lower in patients receiving low, as compared to high, doses of fentanyl [147; interquartile range (IQR), 63–202; vs. 255; IQR, 183–274; p = 0.028], whereas no significant difference was found in those receiving morphine (217; IQR, 165–266; vs. 237; IQR, 165–269; p = 0.09). At 2 h, weight-weighted doses of fentanyl and morphine were significantly correlated to plasma levels of ticagrelor and AR-C124910XX.

Conclusion

In symptomatic patients with STEMI who underwent primary PCI after ticagrelor pretreatment and who received intravenous opioids, we found a dose-dependent relationship between the administration of intravenous fentanyl, but not morphine, and ticagrelor-induced platelet inhibition.
On the relation between oral contraceptive use and self-control
Authors: Smith Alyssa C. , Smilek Daniel
Published: April 2024

In two studies we examined the relation between oral contraceptive (OC) use and self-reported levels of self-control in undergraduate women using OCs (Study 1: OC group N = 399, Study 2: OC group N = 288) and naturally cycling women not using any form of hormonal contraceptives (Study 1: Non-OC group N = 964, Study 2: Non-OC group N = 997). We assessed the self-overriding aspect of self-control using the Brief Self-Control Scale (BSCS) and strategies for self-regulation using the Regulatory Mode Scale (RMS), which separately measures the tendency to assess one’s progress towards a goal (assessment), and the tendency to engage in activities that move one towards an end goal (locomotion). In Study 1, we found no significant differences between OC and non-OC groups in their levels of self-overriding or self-regulatory assessment. However, we found that those in the OC group reported significantly greater levels of self-regulatory locomotion compared to those in the non-OC group, even after controlling for depression symptoms and the semester of data collection. The findings from Study 2 replicated the findings from Study 1 in a different sample of participants, with the exception that OC use was also related to higher levels of assessment in Study 2. These results indicate that OC use is related to increases in self-regulatory actions in service of goal pursuit and perhaps the tendency to evaluate progress towards goals.
Gestational weight gain and pregnancy outcomes in Chinese women with type 2 diabetes mellitus: evidence from a tertiary hospital in Beijing
Authors: Yan Xin , Jia Jianrui , Zheng Wei , Yuan Xianxian , Wang Jia , Zhang Lirui , Li Guanghui
Published: April 2024

Objective

To examine the effects of gestational weight gain on pregnancy outcomes and determine the optimal range of weight gain during pregnancy for Chinese women with type 2 diabetes mellitus.

Methods

This retrospective cohort study included 691 Chinese women with type 2 diabetes mellitus from 2012 to 2020. The study utilized a statistical-based approach to determine the optimal range of gestational weight gain. Additionally, multivariate logistic regression analysis was conducted to assess the impact of gestational weight gain on pregnancy outcomes.

Results

(1) In the obese subgroup, gestational weight gain below the recommendations was associated with decreased risks of large for gestational age (adjusted odds ratio [aOR] 0.19; 95% confidence interval [CI] 0.06-0.60) and macrosomia (aOR 0.18; 95% CI 0.05-0.69). In the normal weight subgroup, gestational weight gain below the recommendations of the Institute of Medicine was associated with decreased risks of preeclampsia (aOR 0.18; 95% CI 0.04-0.82) and neonatal hypoglycemia (aOR 0.38; 95% CI 0.15-0.97). (2) In the normal weight subgroup, gestational weight gain above the recommendations of the Institute of Medicine was associated with an increased risk of large for gestational age (aOR 4.56; 95% CI 1.54-13.46). In the obese subgroup, gestational weight gain above the recommendations was associated with an increased risk of preeclampsia (aOR 2.74; 95% CI 1.02, 7.38). (3) The optimal ranges of gestational weight gain, based on our study, were 9-16 kg for underweight women, 9.5-14 kg for normal weight women, 6.5-12 kg for overweight women, and 3-10 kg for obese women. (4) Using the optimal range of gestational weight gain identified in our study seemed to provide better prediction of adverse pregnancy outcomes.

Conclusion

For Chinese women with type 2 diabetes, inappropriate gestational weight gain is associated with adverse pregnancy outcomes, and the optimal range of gestational weight gain may differ from the Institute of Medicine recommendations.
Delay and cost-balanced communication resource management for IoT-empowered distribution grid energy dispatch
Authors: Shi Zhan
Published: April 2024

The combination of internet of things (IoT), 5G, and power line communication (PLC) provides real-time and low-cost data transmission services to meet the quality of service (QoS) requirements for distribution grid energy dispatch. However, the IoT-empowered communication resource management system faces challenges in optimizing delay and traffic cost for distribution grid energy dispatch. There is a contradiction between the long-term performance guarantee and short-term optimization objectives, compounded by competition for communication resources. In this paper, we construct the minimization problem of the weighted sum of data transmission delay and traffic cost. Utilizing Lyapunov optimization, we aim to decouple the long-term constraint of average queuing delay with the short-term optimization objective. Then, a delay and cost-balanced communication resource management algorithm based on two-layer iterative matching is proposed. It optimizes the communication mode selection by I-to-2 bidding matching in a large timescale and subchannel allocation by many-to-many deferred acceptance matching in a small timescale. The simulation data present that the proposed algorithm excels in reducing data transmission delay, minimizing traffic cost, and decreasing queuing delay.
A study of operational decisions of city gas operators under the energy metering and pricing model
Authors: Wan Qin , Sun Yang , Wen Li , Qi Can , Yu Cuiting
Published: April 2024

This study examines the quantitative conditions under which an energy metering pricing model is proposed to increase both gas merchant profits and gas customer consumer surplus compared to a volumetric pricing model. The quantitative condition is found to be related to factors such as the standard unit calorific value of natural gas prescribed by the National Development and Reform Commission (NDRC) and other relevant government departments under the energy metering pricing model. This paper establishes a mathematical model based on optimization theory to explore the operational decisions of city gas suppliers in the volumetric and energy metering and pricing modes, respectively, under the condition of relatively stable natural gas sales price. The results of the study show that DAC and other authorities can regulate the standard unit calorific value of natural gas under the energy metering and pricing model by regulating the standard unit calorific value of natural gas. This affects the incentives of gas dealers to produce and operate, guides the preference of gas users for natural gas energy metering and pricing, and results in the derivation of formulas for a reasonable range of standard unit calorific values for natural gas. The findings of this paper provide theoretical support to promote the reform of natural gas energy measurement and pricing, and contribute to the development of the natural gas industry.
Localizing the sustainable development goals in smart and sustainable cities: how can citizen-generated data support the local monitoring of SDGs? A case study of the Brussels Capital Region
Authors: Borghys Koen , Vandercruysse Laurens , Veeckman Carina , Temmerman Laura , Heyman Rob
Published: April 2024

Introduction: The Sustainable Development Goals (SDGs) serve as the global reference framework for sustainable development endeavors. However, traditional data sources, including official statistics, fall short in effectively measuring SDG performance, due to substantial gaps in the availability of reliable, timely, actionable, disaggregated, and accessible information for policy formulation. This research explores the SDG monitoring potential of citizen-generated data to enhance local environmental in the Brussels Capital Region.

Methods: Employing a qualitative approach, the study first defines and maps essential characteristics of citizen-generated data for inclusion in environmental SDG monitoring. Subsequently, expert interviews refine these characteristics and explore design requirements tailored to the Brussels Capital Region.

Results: The research culminates in a framework linking essential citizen-generated data characteristics to design requirements, ensuring data suitability for local environmental SDG monitoring.

Discussion: This framework advances the existing literature by specifically addressing local environmental SDG monitoring through citizen-generated data. It offers practical insights for local stakeholders, particularly policymakers, aiming to overcome barriers to the uptake of citizen-generated data and ultimately enhances environmental SDG monitoring in the Brussels Capital Region. The framework’s applicability in other regions or for non-environmental SDG indicators remains a potential avenue for future research.
Multiple functions of the nonstructural protein 3D in picornavirus infection
Authors: Xu Chenxia , Wang Mingshu , Cheng Anchun , Yang Qiao , Huang Juan , Ou Xumin , Sun Di , He Yu , Wu Zhen , Wu Ying , Zhang Shaqiu , Tian Bin , Zhao Xinxin , Liu Mafeng , Zhu Dekang , Jia Renyong , Chen Shun
Published: April 2024

3D polymerase, also known as RNA-dependent RNA polymerase, is encoded by all known picornaviruses, and their structures are highly conserved. In the process of picornavirus replication, 3D polymerase facilitates the assembly of replication complexes and directly catalyzes the synthesis of viral RNA. The nuclear localization signal carried by picornavirus 3D polymerase, combined with its ability to interact with other viral proteins, viral RNA and cellular proteins, indicate that its noncatalytic role is equally important in viral infections. Recent studies have shown that 3D polymerase has multiple effects on host cell biological functions, including inducing cell cycle arrest, regulating host cell translation, inducing autophagy, evading immune responses, and triggering inflammasome formation. Thus, 3D polymerase would be a very valuable target for the development of antiviral therapies. This review summarizes current studies on the structure of 3D polymerase and its regulation of host cell responses, thereby improving the understanding of picornavirus-mediated pathogenesis caused by 3D polymerase.