bluuebunny/crossref_metadata_2025 huggingface dataset:
Group Recommender Systems for Tourism: How does Personality predicts Preferences for Attractions, Travel Motivations, Preferences and Concerns?
Authors: Alves Patrícia , Martins Helena , Saraiva Pedro , Carneiro João , Novais Paulo , Marreiros Goreti
Published: June 2022

To travel in leisure is an emotional experience, and therefore, the more information about the tourist is known, the more personalized recommendations of places and attractions can be made. But if to provide recommendations to a tourist is complex, to provide them to a group is even more. The emergence of personality computing and personality-aware recommender systems (RS) brought a new solution for the cold-start problem inherent to the conventional RS, and can be the leverage needed to solve conflicting preferences in heterogenous groups and make more precise and personalized recommendations to tourists, as it has been evidenced that personality is strongly related to preferences in many domains, including tourism. Although many studies on psychology of tourism can be found, not many predict the tourists’ preferences based on the Big Five personality dimensions. This work aims to find how personality relates to the choice of a wide range of tourist attractions, travelling motivations, and travel-related preferences and concerns, hoping to provide a solid base for researchers in the tourism RS area to automatically model tourists in the system without the need for tedious configurations, and solve the cold-start problem and conflicting preferences. By performing Exploratory and Confirmatory Factor Analysis on the data gathered from an online questionnaire, sent to Portuguese individuals from different areas of formation and age groups (n = 1035), we found all five personality dimensions can help predict the choice of tourist attractions and travel-related preferences and concerns, and that only Neuroticism and Openness predict travelling motivations.
Case Report the Neoplastic Transformation of Gastric Hyperplastic Polyp in a Context of Autoimmune Gastritis: Improving the Diagnosis
Authors: Xing Yunqi , Han Haixiao , Wang Yuxuan , Sun Zhongmei , Wang Linheng , Peng Dan , Guo Xiaoyuan , Yao Na , Yuan Yali , Zhang Wenji , Mao Tangyou , Liu Yuyue
Published: June 2022

Background: Gastric hyperplastic polyp commonly arises in the abnormal background mucosa, including autoimmune gastritis, also known as type A gastritis. There are no obvious clinical symptoms in the early stages of the disease, which makes it easy to be misdiagnosed and missed, and has a potential risk of malignant transformation over time.Case presentation: In 2020, a 67-year-old woman was admitted for review 6 years after gastric adenoma resection. Upper endoscopy revealed multiple lobulated polyps in the gastric body, which was histologically diagnosed as gastric adenomatous polyp as before. Interestingly, we discovered that the patient had undergone multiple polypectomies at the same part, which was inconsistent with the pathogenesis of adenomatous polyp. Then we did histological examination and revealed that partial epithelial hyperplasia and dysplasia, and the neoplastic areas were interlaced with normal mucosa. We further found that the background diagnosis was autoimmune gastritis. These results supported the diagnosis of neoplastic transformation of gastric hyperplastic polyp, not gastric adenomatous polyp. With the doubt of possible be misdiagnosed, we reviewed the medical history. Retrospective analysis in 2014, 2015 and 2016 confirmed the presence of autoimmune gastritis. Unfortunately, serological tests were not performed and no special treatment was done. Fortunately, the correct diagnosis was eventually confirmed as neoplastic transformation of gastric hyperplastic polyp in a context of autoimmune gastritis in 2020, which enables patients to receive normal treatment and monitoring, and avoids further deterioration of the disease. Conclusions: The purpose of this case report is to increase clinical awareness of neoplastic transformation of gastric hyperplastic polyp in a context of autoimmune gastritis, and hope promise for early diagnosis and treatment.
Circ_0000231 Promotes Paclitaxel Resistance in Ovarian Cancer by Regulating miR-140/RAP1B
Authors: Liu Jiao , Wang Han , Xiao Suqin , Zhang Siyang , Qi Ya , Wang Min
Published: June 2022

Purpose: Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the involvement of circ_0000231 in paclitaxel (PTX) resistant ovarian cancer (OC) remains unclear.Methods: The levels of circ_0000231, microRNA-140 (miR-140) and RAP1B were determined by quantitative real-time PCR (qRT-PCR) or Western blot assay. Cell proliferation, PTX- resistance, apoptosis, migration and invasion were assessed by Cell Counting Kit-8 (CCK-8), flow cytometry and transwell assay. The levels of resistant-related and epithelial–mesenchymal transition (EMT)-related proteins were measured by Western blot assay. Target association between miR-140 and circ_0000231 or RAP1B was demonstrated by dual[1]luciferase reporter assay or RNA Binding Protein Immunoprecipitation (RIP). Biological implications of circ_0000231 in ovarian cancer were implemented in tumor xenograft models.Results: Circ_0000231 and RAP1B levels were increased, while miR-140 level was decreased in PTX-resistant OC tissues and cells. Depletion of circ_0000231 could inhibit resistance, proliferation, invasion, migration and EMT and promoted apoptosis in PTX-resistant OC cells, which was opposited by overexpression of circ_0000231. Circ_0000231 acted as a sponge for miR- 140, and RAP1B was revealed to be target gene of miR-140. Circ_0000231 was a key molecule required for growth, migration, and PTX-resistance and was involved in EMT. Circ_0000231 knockdown increased PTX sensitivity of OC in vivo.Conclusion: Knockdown of circ_000231 suppressed PTX-resistant OC progression via regulating miR-140/RAP1B signaling pathway. Circ_0000231 might play vital roles in the tumorigenesis and chemoresistance of OC.
On the power transform of Gaussian multiplicative chaos
Authors: Wisniewolski Maciej
Published: June 2022

The notion of power transform of Gaussian multiplicative chaos (GMC) is introduced. Two-side estimates on the power and the Laplace transforms of GMC and its inverse respectively are presented. The power and the Laplace transforms are embedded by the functions of (almost) the same order giving the new insight into distributional characterization of GMC in a general setup. A progress towards the Wong's conjecture about the decomposition of continuous part of covariance function is given in case of threshold parameter q > 2.
Synthesis of sulfonic SBA-15 by co-condensation and Soxhlet extraction: optimization by shortening the preparation time
Authors: Tonutti L. G. , Maquirriain M. A. , Querini C. A. , Costa Bruno O. Dalla
Published: June 2022

Propyl sulfonic SBA-15 catalysts are of great interest in several fields of chemistry and have exhibited high activity towards numerous reactions. Nonetheless, the incorporation of these functional groups on SBA-15 silica poses several challenges. Grafting techniques may conduct to a non-uniform dispersion of the functional groups on the surface. Co-condensation of the functional precursor during the synthesis of the silica overcomes this drawback, but requires longer syntheses and it has the disadvantage that removal of surfactant cannot be done by calcination because of the thermal stability of the functional groups present on the surface. Thus, the detemplation is limited in this case to extraction by standard procedures which generally involve large amounts of solvent per gram of catalyst, long contact time and limited yield of the template removal. The aims of this work were, on the one hand, to study the reduction of the ripening time for catalysts prepared by co-condensation with sulfonic groups and, on the other hand, to develop a standard procedure which allows achieving a high yield of detemplation and optimizes the amount of solvent needed and the time required, as well as employ a commercially available solvent. Different characterization techniques allowed to conclude that the obtained materials exhibited high surface area and a good degree of mesoscopic order, comparable with materials obtained by traditional procedures. Also, a high degree of template removal was achieved and the sulfonic groups were preserved in functionalized materials. These results are relevant for a further scale-up of the catalysts production.
The differential expression of the two key genes involved in fructans biosynthetic pathway in artichoke vs wild cardoon improves inulin-type fructans
Authors: Ferrari Michele , De Sio Clara , Muto Antonella , Pagliani Stefania , Bruni Ilaria , Bruno Leonardo , Labra Massimo , Cozza Radiana
Published: June 2022

The artichoke (Cynara cardunculus L. subsp. scolymus Hegi) is an intriguing source of indigestible sugar polymers such as inulin-type fructans. In this study the amount and the quality of inulin-type fructans have been evaluated in the cultivated artichoke (Cynara cardunculus L. subsp. scolymus Hegi) as well as in the wild cardoon (C. cardunculus var. sylvestris L. Fiori). The expression pattern of the genes codifying for the two key enzymes sucrose:sucrose 1-fructosyltransferase (1‐SST) and fructan 1‐fructosyltransferase (1‐FFT), involved in fructans biosynthesis, have been also evaluated both in capitula (heads) and rhizomes. The results showed that the inulin-type fructans were much higher in the heads of the wild cardoon than artichoke, one together with a higher expression of the two key genes fructans codifying enzymes. A conspicuous level of inulin-type fructans was found also in the rhizome, supporting the significant role of these compounds in the storage and in protection from cold and/or winter stress. The results indicate that wild cardoon could be a good and suitable crop for inulin production as well a sustainable agri-food system in Mediterranean marginal areas.
Nucleophilic covalent ligand discovery for the cysteine redoxome
Authors: Fu Ling , Jung Youngeun , Tian Caiping , Ferreira Renan , He FuChu , Yang Jing , Carroll Kate
Published: June 2022

The convergence of reactive cysteine-targeted electrophilic fragments and chemoproteomics have dramatically accelerated the discovery of ligandable sites in the proteome. Our genome encodes 214,000 cysteine residues, at least 20% of which are estimated to be redox-active. Oxidation blunts sulfur reactivity toward electrophiles but opens the door to a new class of nucleophilic covalent ligands that target cysteinyl sulfenic acids, which are widespread post-translational modifications. Here we report a quantitative analysis of nucleophilic fragments screened against the human sulfenome. Ligands were discovered for >500 sulfenated cysteines in >400 proteins, including sites not targeted by electrophiles with the same scaffold. Among these were compounds that preferentially react with hepatoma-derived growth factor (HDGF)-related proteins (HRPs) one of which was able to block nuclear transport of this oncoprotein. Nucleophilic fragments provide a rich resource for chemical biology and drug discovery, where ligandability in the human proteome extends beyond protein thiols.
Lower Limb Response to Anti-personnel Landmine Blast Explosions: Injury Assessment and Mitigation Strategies
Authors: Singh Baljinder , Basri Mohammad Ahmed
Published: June 2022

Injuries in lower extremities due to anti-personnel (AP) landmine blasts have been a major cause of amputation in soldiers. Therefore, it is crucial to understand the mechanism of these injuries for designing advanced personnel protective equipment and superior medical interventions. Various attempts have been made to correlate lower limb cadaveric mine blast test data using surrogate models, but till date, no study has been reported to validate it using numerical methods. In this work, a finite element computational framework was developed for landmine blasts using a biofidelic human body lower limb model for validating in situ tibia forces and injury patterns with PMHS (Post Mortem Human Subjects) test data. Based on the reliability of the validated numerical analysis model, efforts were made to elucidate landmine blast physics, blast wave intensity for various mine threats, pathophysiology of lower extremity trauma, and effectiveness of various blast mitigation strategies. Numerical simulations were performed to assess the level of protection offered by a standard army combat boot to the lower limb for an M-14 mine blast. Furthermore, for attenuating the load transmission to the lower limb, aluminium foam sandwich panel has been proposed as a potential shoe insert material due to its high energy absorption capabilities. Compared to the bare foot scenario, aluminum foam shoe insert in double core configuration was effective in minimizing severity of M-14 mine blast injuries by reducing the peak tibia force by 34% with a significant delay in time of arrival of the peak. Additionally, the proposed mine protective shoe concept offers 25.2% more reduction in peak tibia force compared to the standard military combat boot for a charge triggered by victim’s heel.
On the admissibility and input-output representation for a class of Volterra integro-differential systems
Authors: Bounit Hamid , Tismane Mounir
Published: June 2022

This article studies a class of controlled-observed Volterra integro-differential problems in the case that the operator of the associated Cauchy problem generate a semigroup on a Banach space and the integral part being given by a convolution of integrable functions with Lp-admissible observation operators kernel. Sufficient and/or necessary conditions for Lp-admissibility of control and observation operators are given in term of the kernels. In particular, results on the equivalence between the finite-time (or infinite-time) Lp-admissibility and the uniform Lp-admissibility are given for both control and observation operators, extending a generalization of results known to hold for the standard Cauchy problems. Particular attention is paid to the problem of obtaining the input-output representation of such systems, providing a theory which is analogue to that of Salamon-Weiss for linear systems. We mention that our approach is mainly based on the theory of infinitedimensional Lp-regular linear systems in the Salamon-Weiss sense. These results are illustrated by an example involving heat conduction with memory given by some space fractional Laplacian kernel.
Ultra-light photosensor collars to monitor Arctic lemming activity
Authors: Bolduc David , Fauteux Dominique , Bharucha Éric , Trudeau Jean-Marie , Legagneux Pierre
Published: June 2022

Background
Studying the anti-predatory behavior of mammals represents an important challenge, especially for fossorial small mammals that hide in burrows. In the Arctic, such behaviors are critical to the survival of lemmings considering that predation risks are high every summer. Because detailed information about how lemmings use burrows as hideouts is still lacking, we developed a 1.59 g photosensitive collar to record any event of a small mammal moving between a dark area (e.g. burrow) and a bright area (e.g. outside the burrow). Tests of how collars affected lemming behavior were conducted in captivity in Cambridge Bay, Nunavut, Canada in November 2019 and field tests were conducted on Bylot Island, Nunavut, Canada in August 2021.
Results
The device was made of two chemical batteries and a printed circuit board (PCB) equipped with a photosensor and a real-time clock that recorded amplitude transient thresholds of light (lux) continuously. In accordance with ethical use of such devices, we verified that no abnormal loss of body mass was observed in captive or free-ranging lemmings, and no difference in recapture rates were observed between those with and without a collar. Measurements of light intensities revealed consistent patterns with high lux levels at mid-day and lowest during the night. Lemmings showed clearly defined behavioral patterns alternating between periods outside and inside burrows. Despite 24h daylight in the middle of the summer, August nighttime (i.e. 2300 to 0400) lux levels were insufficient for amplitude transient thresholds to be reached.
Conclusion
By taking advantage of the long periods of daylight in the Arctic, such technology is very promising as it sets new bases for passive recording of behavioral parameters and builds on the prospect of further miniaturization of batteries and PCBs.
Acoustic and Thermoacoustic Jet Propulsion
Authors: Schoenmaker Jeroen , Machado Danilo Almeida , Frandini Heriques , Junior Annibal Hetem , Mota Fábio
Published: June 2022

This manuscript bridges the fields of jet propulsion, synthetic jets and thermoacoustic engines. We put forward the case that acoustic air jets can be considered as a consistent approach for propulsion systems. Hitherto, studies on synthetic jet propulsion have been scattered and rather subsidiary. Furthermore, investigating with the perspective of propulsion can give new insights to the field of synthetic jets, and the physics of propulsion. We developed and characterized the propulsion properties with regard to several relevant parameters such as geometric factors, frequency and intensity of acoustic jets produced electromechanically and thermally. We demonstrated 10.4 mN and 2.7 mN thrust in the acoustic and thermoacoustic modes respectively, using compact tabletop assemblies. The physical mechanism of the jets has been modelled, simulated, verified with Schlieren imaging and laid in the perspective of adherent literature. Similarities and differences with regard to traditional jet propulsion systems are discussed. As an essentially unexplored avenue, several improvement directions are indicated.
PPDMIT: A Lightweight Architecture for Privacy-Preserving Data Aggregation in the Internet of Things
Authors: gheisari mehdi
Published: June 2022

Data is generated over time by each device in the Internet of Things (IoT) ecosphere. Recent years have seen a resurgence in interest in the IoT due to its positive impact on society. However, due to the automatic management of IoT devices, the possibility of disclosing sensitive information without user consent is high. A situation in which information should not be unintentionally disclosed to outside parties we do not trust, i.e., privacy-preserving. Additionally, IoT devices should share their data with others to perform data aggregation and provide high-level services. There is a trade-off between the amount of data utility and the amount of disclosure of data. This trade-off has been caused a big challenge in this field. To improve this trafe-off efficiency rather than current studies, in this study, we propose a Privacy-Preserving Data Aggregation architecture, PPDMIT, that leverages homomorphic paillier encryption, K-means, a one-way hash chain, and the Chinese Remainder Theorem. We have found that the proposed privacy-preserving architecture achieves a more efficient data aggregation than current studies and improves privacy preservation by utilizing extensive simulations. Moreover, we found that our proposed architecture is highly applicable to IoT environments while preventing unauthorized data disclosure. Specifically, our solution depicted 8.096% improvement over LPDA and 6.508% over PPIOT.
Anatomical basis for the trigeminal autonomic cephalalgia-like response produced by 2 formalin injection into the facial cheek in rats
Authors: Wang Ming R. , Tseng Ching J. , Kuo Jon S.
Published: June 2022

Trigeminal autonomic cephalalgias (TACs) comprise cluster headaches and are characterized 19 by unilateral neuralgiform headache attacks associated with autonomic responses and somatic 2 20 responses. An animal model for evaluating the anatomical basis of the TAC-like response is 21 not currently available. Twenty-five rats weighing 550-650 g were anaesthetized with 22 urethane. The TAC-like response was produced either by subcutaneous injection of formalin 23 into the unilateral facial cheek or by electrical stimulation of the unilateral intact trigeminal 24 nerve. The induced TAC-like response, which included ipsilateral common carotid arterial 25 flow (iCCAF) and other autonomic responses, was studied in intact nerves or after cutting 26 either the ipsilateral trigeminal nerve or the ipsilateral facial nerve. The formalin injections 27 produced concentration-dependent iCCAF increases accompanied by ipsilateral autonomic 28 responses of rhinitis-like nasal congestion, nasal mucus, meiosis, lacrimation, red eye, and 29 eyelid oedema. The formalin (5% or 10%, 0.5 cc)-induced responses were nearly abolished 30 by sectioning of either the facial or trigeminal nerve. The electrical stimulation (15 V, 60 Hz, 31 and 0.4 ms) of the intact trigeminal nerve or its ophthalmo-maxillary branch also produced 32 stimulation strength-dependent iCCAF increases as well as autonomic responses; however, 33 the electrical stimulation-induced iCCAF increases and other autonomic responses could still 34 be induced by electrical stimulation of the central but not the peripheral end of the 35 ophthalmo-maxillary branch (n = 8) or the trigeminal nerve (n = 2). Thus, an animal model 36 for inducing the TAC-like response by subcutaneous formalin injection into the rat facial 37 cheek was established. The TAC-like response could be sequentially mediated via the 38 afferent trigeminal nerve, trigeminal nucleus, dorsal facial nucleus, and efferent facial nerve.
Decreased psychiatric symptomatology after the onset of COVID-19 pandemic: A longitudinal college mental health study from Turkey
Authors: ercandogan asli
Published: June 2022

Objective
COVID-19 pandemic brought significant challenges for college students. This study aimed to investigate changes in psychiatric symptomatology among them compared to the pre-pandemic period alongside their determinants.
Methods
Data were collected before and three months after the onset of the pandemic from 168 students who had applied to a college mental health center. Psychiatric symptomatology was assessed by Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS). Possible vulnerability factors were screened by a survey on COVID-19-related health and social isolation status, Fear of COVID-19 Scale, Social Media Use Disorder Scale (SMDS), Distress Thermometer, Scoff Eating Questionnaire, and International Physical Activity Questionnaire Short-Form (IPAQ).
Results
PHQ-9, GAD-7 and ASRS scores significantly declined in the follow up. Even though the screen time increased, SMDS scores significantly declined. SMDS had a direct effect on PHQ-9 and ASRS levels, in addition to an indirect effect through Stress Thermometer. Higher SMDS scores predicted higher anxious and depressive symptomatology in repeated assessments. Fear of COVID-19 scores had a direct effect on GAD-7 scores only.
Conclusion
This study suggested that stress level and psychiatric symptomatology of the students decreased significantly in the early phases of the pandemic. Level of social media use disorder should be taken into account while following college students with mental health symptoms.
Single-nucleus RNA sequencing of the midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes
Authors: Puvogel Sofía , Alsema Astrid , Kracht Laura , Webster Maree , Weickert Cynthia , Sommer Iris , Eggen Bart
Published: June 2022

The midbrain is an important brain region for the study of schizophrenia in view of its reported dopamine pathophysiology and observed neuroimmune changes associated with schizophrenia. Besides the dopaminergic system, the midbrain contains other cell types that may be involved in schizophrenia pathophysiology. The neurovascular hypothesis of schizophrenia postulates that both the neurovasculature structure and the functioning of the blood-brain barrier (BBB) are compromised in schizophrenia. In the present study, potential alteration in the BBB of patients with schizophrenia was investigated by single-nucleus RNA sequencing of post-mortem midbrain tissue (14 schizophrenia cases and 15 matched controls). We did not identify changes in the relative abundance of the major BBB cell types, nor in the sub-populations, associated with schizophrenia. However, we identified 14 differentially expressed genes in the cells of the BBB in schizophrenia as compared to controls, including genes that have previously been related to schizophrenia, such as FOXP2 and PDE4D. These transcriptional changes associated with schizophrenia were limited to the ependymal cells and pericytes. This schizophrenia cohort was previously stratified into “high inflammation” and “low inflammation” cases, based on cortical inflammation-related transcripts. We detected a sub-population of protoplasmic astrocytes enriched in the high inflammation schizophrenia subgroup. Genes more abundantly expressed in these schizophrenia-related protoplasmic astrocytes were associated with glutamatergic synaptic function rather than with inflammation. In summary, transcriptional changes in the cells of the BBB in schizophrenia are limited and specific. In addition, inflammation may be affecting the function of astrocytes in a subgroup of schizophrenia patients, and thereby contribute to schizophrenia pathophysiology.
Teledentistry in the Malaysian Context: Are We There Yet?
Authors:   Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia, Mohamed Nazari Nor Shafina , Wafa Sharifah Wade’ah Wafa Syed Saadun Tarek ,   Department of Paediatric Dentistry & Orthodontics, Faculty of Dentistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia, Baharuddin Nor Adinar ,   Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia
Published: June 2022

Teledentistry has been proven to have the potential in addressing the gap in accessing oral health care worldwide. Nevertheless, more information is needed to support evidence-based teledentistry practice in Malaysia. The article aims to review teledentistry in view of implementing it to be a common practice in Malaysia. The authors describe teledentistry application worldwide, as well as its uses in the field of service and education. The article summarises the needs of teledentistry in South East Asia, as well as the ethical perspectives and legal practices. In addition, the article also reviews the opportunities arising from practicing teledentistry, including during the unprecedented COVID-19 pandemic. Following review, teledentistry seems to be a promising path as it could offer solutions to shortages in the workforce, high demand for treatment needs and unequal service distribution due to lack of accessibility in rural areas in Malaysia. Furthermore, teledentistry can extend care to underserved patients and provide opportunities to supplement teaching in dental education. The authors provide recommendations to overcome challenges to ensure a sustainable teledentistry. Incorporating teledentistry into practice in Malaysia is achievable but proper guidelines are required.
Elucidating the Cognitive Mechanisms Underpinning Behavioural Activation
Authors: Myles Liam , Merlo Emanuele
Published: June 2022

Depression represents a pervasive and devastating psychological difficulty. It affects over 21% of the population at some point in their lives and can have an unimaginable impact on both individuals and society. Behavioural activation represents a popular intervention for depression and is commonly used by psychologists internationally. Despite its popularity, the cognitive mechanisms underpinning the efficacy of behavioural activation remain elusive. This paper will review the literature on this intervention and propose an account of the cognitive mechanisms underlying its therapeutic efficacy. Specifically, it is argued that behavioural activation is effective because it increases both the density of outcomes in ones environment and the density of highly salient action-outcome contingencies, which may otherwise be absent due to reduced motivation. The clinical implications are subsequently discussed, with reference to future research.
Social Stigma: A Systematic Review of Cognitive Insights from Behavioral Economics (1940–2019)
Authors: Vecchio Camargo Carolina Mercedes , Rodríguez Acosta Sandra Milena , Aristizabal Diaz-Granados Edith Teresa
Published: June 2022

There are minority and stigmatized groups who face particular challenges to their full participation in society. This study’s objective was to conduct a systematic review to determine theoretical and methodological underpinnings in behavioral economics that explain how stigmatization emerges within the relationship processes and social structures of individuals. Data from 1940 to 2019 were sourced from 12 relevant electronic databases such as Scopus and Web of Science. Following PRISMA guidelines for systematic reviews, 26 studies out of 3459 met the inclusion criteria. Most of the studies applied experimental economics and were published between 2002 and 2018. Overall, the articles focus their research on the experiences of discrimination based on stereotypes and test their hypotheses through economic games. The data synthesis seems to reveal weak conceptual clarity, circular reasoning, and a hint of the problem of infinite regress. Thus, these issues open new and exciting avenues for future research to explore via an array of experimental applications.
Lipid Profile of Human Milk in Different Lactation Stages Submitted to Pasteurization, Lyophilization and Spray-Drying Processes
Authors: Neia Vanessa , Santos Patrícia , Tavares Christyna , Paula Meliana , Costa Silvio , Zacarias Joana , Alencar Josiane , Silveira Roberta , Santos Oscar , Visentainer Jeane , Visentainer Jesuí
Published: June 2022

The objective of this study was to evaluate the effect of pasteurization, lyophilization and spray-drying on the lipid profile of donated human milk (DHM) at different lactation stages. Nine frozen samples of colostrum, transitional and raw mature human milk (HM) were collected from the Human Milk Bank (HMB) of the Hospital Universitário de Maringá (HUM). Samples were thawed and pooled according to lactation stage. Thereafter, it was submitted to pasteurization, lyophilization and spray-drying processes and later the fatty acid (FA) composition and the lipid profile analyses were performed. Gas chromatograph (GC) with flame ionization detector (FID) and electrospray ionization (ESI) mass spectrometer (MS) were used, respectively. In the FA composition analysis, it was observed that the same classes of saturated FA (SFA), monounsaturated FA (MUFA) and polyunsaturated FA (PUFA) were preserved throughout the process and in all lactation stages. The lipid profiles were also preserved after processing. Therefore, the lyophilization and spray-drying processes are promising techniques to preserve the DHM in the HMB, once the components evaluated were preserved, and both techniques facilitate the transport and storage, as the techniques reduce the sample volume.
Digital inventory of agricultural land plots in the Kemerovo Region
Authors: Rada Artem , Kuznetsov Aleksandr
Published: June 2022

Cadastral and geodetic land works are expensive, which makes aerial photography extremely valuable for land traceability and inventory. The present research objective was to develop a new digital survey technology for registration of agricultural lands. We assessed the accuracy of the new method and evaluated its decision support options. The study featured the case of the Kemerovo Region (Kuzbass), Russia.

The aerial survey took place in 2021 and involved 17 municipalities of the Kemerovo Region. The software and hardware complex included an unmanned aerial vehicle (UAV) and a module for aerial photography. Photogrammetric, cartometric, and satellite methods were used to define the coordinates of feature points. We developed new software (Sovhoz.avi) to perform the land inventory.

The photogrammetric and cartographic methods proved efficient in determining the feature points and boundaries of land plots. They also appeared accurate enough for land inventory and decision support. The study updated the available land inventory data. About 30% of all land plots were recorded incorrectly; some plots marked as agricultural appeared to belong to the local forest reserves or urban territories. Incorrect data (1.64%) were excluded from the official inventory. The survey covered a total area of 41 000 ha and revealed 1700 illegally used land plots. The updated inventory of unused lands included 3825 new plots (163 400 ha), which can attract prospective investors.

The results can be used by the local authorities to make land management decisions and identify illegal land use.
A hybrid artificial intelligence and semi-distributed model for runoff prediction
Authors: Narayana Reddy Beeram Satya , Pramada S. K.
Published: June 2022

Hydrological simulations perform a vital role in river discharge forecasts, which is very essential in water resources engineering. The present study has been carried out using a semi-distributed model developed using HEC-HMS, an artificial neural network (ANN), and a hybrid model (HEC-HMS-ANN) for simulation of daily discharge in the Kallada River basin, Kerala, India. The HEC-HMS model did not perform well with the available dataset. So for simulating daily runoff, a hybrid model is developed by coupling HEC–HMS output with ANN. The model prediction accuracy is assessed using statistical metrics. Precipitation, lagged precipitation, and lagged discharge were used as input variables for the ANN model. The optimal number of lags was determined using partial autocorrelation. The hybrid model integrating the output from HEC-HMS into ANN shows better performance than the other models in simulating daily discharge and estimating the accuracy of yearly peak discharge. The accuracy evaluation of yearly peak discharge values demonstrates that simulation error is reduced by 66% and 26.5% in the hybrid model compared to the HEC-HMS and ANN models, respectively.
LA FUNCIÓN INTERMEDIARIA DEL CONATUS EN DE ANTIQUISSIMA DE G. VICO
Authors:   Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile, Molina Johannes Javier
Published: June 2022

En el presente artículo exponemos la función del concepto de conatus a partir del De Antiquissima. En primer lugar, revisamos la relación que tiene con el movimiento y, a su vez, con los puntos metafísicos. Luego, exhibimos la posibilidad de pensar la conexión entre Dios y los humanos a través del ánimo y la mente. Por último, se esclarece el papel del Sumo Hacedor con la correspondiente Fortuna en la red conceptual de G. Vico para proponer una lectura de la obra a partir de la intermediación que realiza el conatus, produciendo el vínculo entre lo divino y lo humano en el De Antiquissima.
Prognostic Significance of Risk Factors and Biomarkers in Patients
Hospitalized for Cardiorenal Syndromes: A Pilot Study
Authors: Theofilis Panagiotis , Vordoni Aikaterini , Nakas Nikos , Kotsakis Athanasios , Kranidis Athanasios , Makryniotou Ioanna , Kalaitzidis Rigas G.
Published: June 2022

Background:

Cardiorenal syndromes (CRS), involving the heart-kidney cross-talk and the activation of neurohumoral and inflammatory pathways, is an entity characterized by high morbidity and mortality.

Objective:

To evaluate the prognostic role of risk factors and biomarkers in patients hospitalized for CRS.

Methods:

In this observational cohort study, 100 consecutive patients hospitalized for CRS were enrolled. Socio-demographic characteristics, personal medical history, and prior medication use were recorded upon admission, and echocardiography was performed. Moreover, an array of blood markers were measured. The endpoint of interest was a composite of death or dialysis dependence at discharge.

Results:

Patients were classified into two groups; Group 1 (N=52): discharged being dialysis-independent, Group 2 (N=48): death/dialysis dependence at discharge. No significant differences were detected in baseline characteristics between the two groups. Group 2 patients used renin-angiotensin-aldosterone system blockers (RAASb) less often and more frequently presented with oliguria/anuria. Group 2 patients had significantly lower hemoglobin, serum albumin, and 25-hydroxy-vitamin D [25(OH)D]. At the same time, serum phosphate, potassium, and parathyroid hormone (PTH) were significantly higher in Group 2 patients. In a multivariate regression analysis, lack of prior RAASb and lower 25(OH)D levels were independently associated with an increased risk of death or dialysis dependence at discharge. 25(OH)D/PTH ratio was the most accurate predictor of the composite endpoint (Sensitivity: 79.4%, Specificity: 70.4%).

Conclusion:

Lack of prior RAASb use, high PTH, low 25(OH)D levels, and low 25(OH)D/PTH ratio are associated with a poor prognosis in patients hospitalized for CRS.
Attacking the SARS-CoV-2 Replication Machinery with the Pathogen
Box’s Molecules
Authors: Osorio-Mogollón Cleidy , Olivos-Ramírez Gustavo E. , Otazu Kewin , Chenet-Zuta Manuel E. , Ropón-Palacios Georcki , das Dores Aguiar Cinthia , Camps Ihosvany , Jimenez-Avalos Gabriel M. , Apari-Cossio Eduardo , Torres Moreira Natalia E. , Cárdenas-Cárdenas Reyna G.
Published: June 2022

Introduction:

The world is currently facing a pandemic caused by the new coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus. Viral transcription and replication are within the fundamental processes of any virus. They allow the synthesis of genetic material and the consequent multiplication of the virus to infect other cells or organisms.

Methods:

The most important protein in SARS-CoV-2 is the RNA polymerase (RdRp or nsp12), responsible for both processes. The structure of this protein (PDB ID: 6M71) was used as a target in the application of computational strategies for drug search, like virtual screening and molecular docking. Here, Pathogen Box database of chemical compounds was used together with Remdesivir, Beclabuvir, and Sofosbuvir drugs as potential inhibitors of nsp12.

Results:

The results showed a Top10 potential target inhibitor, with binding energy (∆G) higher than those of the positive controls, of which TCMDC-134153 and TCMDC-135052, both with ∆G = −7.53 kcal/mol, present interactions with three important residues of the nsp12 catalytic site.

Conclusion:

These proposed ligands would be used for subsequent validation by molecular dynamics, where they can be considered as drugs for the development of effective treatments against this new pandemic.
Retinal Tissue Engineering: Regenerative and Drug Delivery Approaches
Authors: Aghmiuni Azadeh Izadyari , Keshel Saeed Heidari , Rahmani Ali , Nadri Samad , Sefat Farshid , Lashay Alireza
Published: June 2022

Absatract:

In recent decades, the improvement of photoreceptor/ cell transplantation has been used as an effective therapeutic approach to treat retinal degenerative diseases. In this reviwe, the effect of different factors on the differentiation process and stem cells toward photoreceptors along with cell viability, morphology, migration, adhesion, proliferation, and differentiation efficiency was discussed. It is no wonder that scientists are researching to better recognize the reasons for retinal degeneration, as well as discovering novel therapeutic methods to restore lost vision. In this field, several procedures and treatments in the implantation of stem cells-derived retinal cells have explored with some example of clinical trials. Although these clinical trials are too small to draw stable decisions about whether stem-cell therapies can offer a cure for retinal diseases. However, the future research directions have started for patients affected by retinal degeneration and promising findings have been obtained.
Impact of Nanoclays on Polyvinylidene Fluoride Mixed Matrix Membranes
for the Efficient Treatment of Oily Wastewater
Authors: Yogarathinam Lukka Thuyavan , Ismail Ahmad Fauzi , Arthanareeswaran G. , Azali Mohd Ariff Bin , Ramli Mohd Khairul Naim Bin , Rushdan Ashraf
Published: June 2022

Background:

Membrane technology demonstrated a sustainable methodology for water reclamation from oily-wastewater, but it is prone to fouling during longer filtration runs. In this study, fouling resistant polyvinylidene fluoride (PVDF) mixed matrix membranes (MMMs) containing nanoclays such as halloysite (HT) and montmorillonite (MMT) were fabricated for the effective treatment of oily wastewater.

Methods:

Phase inversion technique was followed for the fabrication of HT-PVDF and MMT-PVDF MMMs. Physiochemical characterization and filtration experiments were studied to evaluate the influence of nanoclays on PVDF membrane performance.

Results:

Fourier transform infrared spectroscopy (FTIR) and morphology analyses indicated that both nanoclays are layered structured with abundant hydrophilic functional groups. The dispersions of HT and MMT were confirmed by surface morphology and topography analysis of PVDF MMMs. The hydrophilicity property was improved in HT-PVDF and MMT-PVDF MMMs, which was evident in the contact angle analysis. Among the membranes, MMT-PVDF MMMs held the higher water permeability of 2.59 x10-8 m/s.kPa. For oil-water filtration, HT-PVDF and MMT-PVDF MMMs displayed higher normalized flux with maximum rejection of more than 95%.

Conclusion:

Overall, MMT would be cost-effective nanofiller for the development of antifouling PVDF MMMs against oil-water filtration.
Novel Herbal Nanocarriers for Treatment of Dermatological Disorders
Authors: Shree Dipthi , Patra Chinam Niranjan , Sahoo Biswa Mohan
Published: June 2022

Background and Objective:

In the present scenario, the use of novel nanocarriers to provide
a better therapy regimen is noteworthy. Nanotechnology with the advanced system enables the
herbs for encapsulation within the smart carrier and boosts the nanotherapeutic. These emerging innovations
of herbal nanocarriers have paved the way for dermal targeting by eliciting the desired response
for particular diseases.

Method:

In this current manuscript, an extensive search is conducted for the original research papers
using databases, viz., Google Scholar, PubMed, Science Direct, etc. Furthermore, painstaking efforts
are made to compile and update the novel herbal nanocarriers, such as liposomes, ethosomes, transferosomes,
niosomes, nanoemulsions, nanogels, nanostructured lipid carriers, solid lipid carriers, etc.,
which are mostly used for the treatment of several skin maladies, viz., eczema, psoriasis, acne, etc.
This article highlights the recent findings that the innovators are exclusively working on herbal drug
delivery systems for dermal targeting, and these are enumerated in the form of tables.

Conclusion:

Herbal formulations employing a suitable nanocarrier could be a promising approach for
the treatment of several pathological conditions, including skin ailments. Therefore, scientific research
is still being carried out in this specific area for a better perspective in herbal drug delivery and targeting.
Post-Coronavirus Disease Mucormycosis: Predisposing Factors and
Possible Treatment: A Narrative Review
Authors: Garg Vandana , Sinhmar Sonali , Malhotra Hitesh , Dutt Rohit
Published: June 2022

Absract:

Mucormycosis, commonly known as black fungus, is a life-threatening fungal infection belonging to the order Mucorales. It affects individuals having an impaired immune response or immune disorders such as diabetes mellitus, induced immunosuppression, hematological cancers, acquired immune deficiency syndrome, or who have gone through organ transplantation. Black fungus had symptoms like difficulty in breathing, blurred vision, coughing out blood, chest pain, blackening over the area of the nose. Tissue necrosis is the main symptom of this infection. It was increasing day by day and seen in vulnerable patients, including patients which were suffering from COVID 19 (coronavirus) and who were recovered. As we had seen that black fungus cases were rising in recovered COVID patients, various cases of white and yellow fungus were also reported.The treatment approach includes the use of antifungal agents, triazoles, surgery, combination therapy, etc. This review describes the clinical manifestation, predisposing factors, and treatment strategy of mucormycosis.
Fredrika Runeberg: A Pioneer Editor and a Cultural Transmitter in Mid-Nineteenth Century Finland: A Pioneer Editor and a Cultural Transmitter in Mid-Nineteenth Century Finland
Authors: Capkova Viola , Launis Kati
Published: June 2022

Fredrika Runeberg: A Pioneer Editor and a Cultural Transmitter in Mid-Nineteenth Century Finland
“London Horrors” (1861): John Hollingshead’s Investigative Journalism and the Multi-Genre Evolution of Social Research
Authors: Schwab Christiane
Published: June 2022

This article analyzes how the series ‘London Horrors’ documented the living conditions of the underprivileged sections of the urban population for the Morning Post (1772-1937). Its writer, John Hollingshead (1827-1904), did not only aim to provide a testimonial on the effects of nineteenth-century social transformations but also to stimulate societal reflection among a growing reading public. Looking at ‘London Horrors’ as an early example of social research, this article examines the series’ narrative schemes, Hollingshead’s methodological reflections, and the strategies he employs to raise political awareness among his audience. The expanding and commercializing market of journals and magazines of the nineteenth century, the article argues, constituted an important context for the multi-genre evolution of social thought.
the Press coverage of the 2008 presidential election campaign in Cyprus
Authors: Themistokleous Antigoni
Published: June 2022

This article examines the tension created by the existence of differentiated interpretations of the freedom of the press as an institutional right and considers the regulatory potential or the constraint of self-regulation to address the implications of this tension. Qualitative content analysis of press reporting of the 2008 presidential election campaign in Cyprus and document analysis of the Cyprus Journalists’ Code of Practice and of a Guidance Note issued by the self-regulatory agency are used to analyse the data. This article demonstrates that the most fundamental challenge the press self-regulation should address is the complexity in evaluating among different but equally important liberal rights, whose conjunction creates conflict. The findings demonstrate that defining the boundaries of press freedom in order to safeguard balanced and non-discriminatory reporting is a complex process. Emphasising the public’s right to information may jeopardize the journalistic autonomy and the editorial independence as there is no straightforward way to make judgments about incommensurable values such as free speech. This article exemplifies that political reporting is a challenging context as far as the regulability of press freedom is concerned.
The position of Flanders within the context of internationalisation in post-war Belgium: The case of L’Art libre (1919-1922).
Authors: Mus Francis
Published: June 2022

see article