bluuebunny/crossref_metadata_2025 huggingface dataset:
ТРАНСФОРМАЦІЯ СОЦІАЛЬНО-ТРУДОВИХ ВІДНОСИН НА ПІДПРИЄМСТВАХ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ
Authors: Косінцева П.Ю.
Published: December 2024

В статті доведено, що людина є джерелом знань, умінь та новаторських можливостей підприємств залізничного транспорту. Встановлено, що наразі світ та національна економіка відчувають трансформаційні процеси спричинені становленням цифровізації. Цей факт активує цифрові зміни в усіх сферах діяльності підприємств залізничного транспорту. Трансформації торкнулися також кадрових ресурсів. Спостерігається трансформація моделі соціально-трудових відносин на підприємствах залізничного транспорту, що спричиняє зміну: роду та характеру зайнятості, вимог до професійних компетенцій працівників, моделі управління персоналом, системи підготовки та розвитку персоналу. Трансформації кадрового капіталу відбуваються на фоні запровадження воєнного стану в державі, негативних змін на ринку праці України, а також критичного фінансово-економічного положення підприємств залізничного транспорту. Це обумовлює формування нових концепцій, форм та методів управління трудовим капіталом відповідно до умов сьогодення.
ЗМІНЕНИЙ СТАН СВІДОМОСТІ ЯК ДОМІНАНТНА СТРАТЕГІЯ ПОЕТИКИ РОМАНУ Ю. ІЗДРИКА «ВОЦЦЕК»
Authors: Томбулатова Іраїда Ігорівна
Published: December 2024

У дослідженні сфокусовано увагу на ролі та функціях змінених станів свідомості у літературному тексті. Підкреслено, що змінені стани свідомості мають різноманітні впливи на художній світ літературного твору, структуру відносин у системі персонажів та можуть змінювати конструкцію хронотопу. Змінені стани свідомості можуть бути різноманітними за своєю природою та наслідками, ба більше, мають широку палітру (від екстазу до агонії, від сну до адитивних станів, спричинених різного роду субстанціями / речовинами). Протягом усієї історії літератури автори зверталися до змінених станів свідомості або імплементували до сюжету героїв, що переживають або мають досвід переживання зміненого стану свідомості. Сучасна світова література не є винятковою, автори залучають змінені стани свідомості з різних мотивів та показують різні наслідки таких станів, але цікавим питанням є те, чим саме характеризується такий літературний текст, на які його конструкти може вплинути введений у текст змінений стан свідомості як стратегія. Очевидно, що кожен текст є унікальним. Статтю присвячено аналізу твору сучасної української літератури – роману «Воццек» Юрія Іздрика. За основу в статті взято два змінені стани свідомості, що є різними почасти своєї природи: стан сну та алкогольного сп’яніння, останній із яких може бути адитивним та пов’язаний із вживанням конкретної речовини. Варто зазначити, що у статті проаналізовано, як саме кожен із цих змінених станів свідомості суто формально впливає на текст роману, як бере участь у побудові ситуацій, подій, як зміна поведінки або мислення одного з героїв може трансформувати систему персонажів тощо. На конкретних прикладах продемонстровано основні бінарні опозиції, які вибудовуються за рахунок наявності у романі «Воццек» змінених станів свідомості. Отже, увагу сфокусовано не стільки на психологічному, скільки на літературознавчому аналізі тексту.
Marca de agua. Experiencias de escritores en torno a la lectura
Authors:   Universidad de Guadalajara, Rosas Chávez Patricia , Souza Jauffred Jorge Alfredo , Olivares Cortés Godofredo , Yáñez López Ricardo , del Palacio Montiel Celia , de Aguinaga Zuno Luis Vicente , Aguilera Méndez Anja , Zamora Puente María Yolanda , Hernández Muñoz Laura , Trejo Zaragoza Óscar , López Hernández José Daniel , Velasco Gutiérrez Sara , Madrigal Toribio Francisco Javier , Villarreal Macías Rogelio , Zamudio Aguiar Ana Claudia , Velasco Medina Patricia Adriana , Heredia Cubillos Mario Adolfo , Aranda Araiza Carolina , Bátiz Torres Blanca , Camarena Meillón Rossana , Zarazúa Villaseñor Ulises , Quezada Camberos Silvia Magdalena , Ortega Ojeda Alfredo Tomás , Cruz Flores Jesús , Carrillo Collard Patricia , Solórzano Pérez Laura , Martín Quiroz Gabriel Aurelio
Published: December 2024

En Marca de agua. Experiencias de escritores en torno a lectura, se reúnen veinticuatro testimonios, marcas de agua, de escritores que reflejan sus primeros acercamientos a los mundos literarios. Cada uno muestra, desde la intimidad de su biografía, aquella marca única e inimitable que le dejó su acercamiento a la lectura: la forma en que se adentró en aquellos primeros libros que plasmaron la huella imborrable de la que hablamos, en el corazón de su corazón. Este libro es, entonces, un testigo de una parte del panorama literario contemporáneo y de los caminos recorridos por sus autores.
Analisis Bauran Pemasaran dalam Meningkatkan Penjualan Usaha Perabot Risky di Kota Jambi
Authors: Erdani Risky Olivia , Baining Mellya Embun , Anggraini Dessy
Published: December 2024

Dinamika bisnis yang berkembang secara terus-menerus di berbagai sektor industri. Pada era transformasi seperti sekarang ini, banyak sekali pilihan berbagai produk yang beredar di pasaran dan meningkatkan intensitas dalam persaingan bisnis. Konsumen kini memiliki kebebasan untuk memilih produk yang paling sesuai dengan kebutuhan dan preferensi pribadi. Bauran pemasaran terdiri dari produk, harga, tempat, promosi, orang, proses, dan bukti fisik. Penelitian ini bertujuan untuk menganalisis penerapan strategi bauran pemasaran di Usaha Perabot Risky di Kota Jambi. Penelitian ini menggunakan metode kualitatif, data dikumpulkan melalui wawancara, observasi, dan analisis dokumen dari Usaha Perabot Risky. Hasil penelitian menunjukkan bahwa strategi pemasaran yang diterapkan oleh Perabot Risky berfokus menyediakan layanan custom furniture yang sesuai kebutuhan dan selera mereka, menawarkan harga yang kompetitif dengan tetap menjaga kualitas produk dan masih menggunakan metode personal selling untuk promosi. Strategi bauran pemasaran Perabot Risky dari produk yang ditawarkan adalah furniture custom dengan kualitas bahan yang baik, harga yang kompetitif, fleksibilitas desain, lokasinya strategis, promosi masih terbatas, meskipun proses produksi sudah efisien, penekanan kualitas dan manajemen komunikasi dengan konsumen perlu ditingkatkan
O Uso da Metodologia Ativa Jigsaw no Curso de Graduação em Enfermagem
Authors: Costa Giovanna Martins , Silva Patrícia Costa dos Santos da
Published: December 2024

O Jigsaw é uma metodologia que estimula a autonomia, a criatividade, o trabalho em equipes e o aprimoramento de habilidades e de competências socioemocionais. Nesse sentido, o objetivo deste estudo é relatar a experiência do uso da metodologia do Jigsaw na disciplina Saúde da Família no curso de Graduação em Enfermagem, bem como as potencialidades e as fragilidades em sua utilização. Os resultados mostram como potencialidades a promoção do trabalho em equipe, o incentivo à pesquisa e a interação. Em relação às dificuldades, a organização do tempo e do espaço físico. Conclui-se que o método Jigsaw permitiu a criação de cenários favoráveis à cooperação, à comunicação e ao trabalho em equipe.
Perfil Genotípico do Complexo HLA e Descrição de Fatores Clínicos de Pacientes Internados em Enfermaria por Covid-19 na Região de Foz do Iguaçu
Authors: Grignet Pedro Henrique , Assis Samuel Chagas de , Schneider Carlos Henrique , Terencio Maria Leandra , Zarpelon Luis Fernando Boff , Alves Tatiana Pinheiro Rocha de Souza , Gross Maria Claudia
Published: December 2024

Em cenário complexo da pandemia COVID-19, conhecer o comportamento da doença, seus mecanismos biológicos e fatores que podem influenciar sua expressão mostra-se fundamental para o desenvolvimento de estratégias eficientes. Este estudo teve como objetivo verificar o perfil genotípico do complexo HLA, componente genético crucial do sistema imunológico, de pacientes acometidos pela COVID-19 e internados na enfermaria do Hospital Municipal Padre Germano Lauck, Foz do Iguaçu, através de sequenciamento de DNA e também descrever as características clínicas desses pacientes, incluindo idade, sexo, peso e a presença de comorbidades. Os dados foram coletados em prontuários eletrônicos, preservando a identidade dos pacientes. Foram identificados os grupos alélicos de HLA classe I locus B de 19 pacientes, internados de outubro a novembro de 2020. Os grupos alélicos B*44 e B*15 apresentaram maior frequência nestes pacientes. A média de idade dos internados foi de 67,7 anos, sendo que a média de dias na enfermaria de 8,2 dias e 74% dos desfechos foi de alta.
Religiusitas dan Dukungan Sosial sebagai Penentu Konsep Diri: Studi Kasus pada Perempuan Korban Perselingkuhan
Authors: Yulianty Eva Fitria , Fadillah Siti Sekar Ayu , Zazirah S , Riany Yulina Eva
Published: December 2024

Infidelity is a complex social issue that has profound psychological impacts on its victims. Infidelity does not always involve sexual relationships; it can also manifest as emotional closeness. However, any form of infidelity has the potential to undermine the integrity of a marital bond. While infidelity can occur in both men and women, research identifies men as more likely to engage in such behavior. This study aims to analyze the impact of a husband’s infidelity on a wife’s self-concept. A qualitative phenomenological method was employed. The findings, based on interviews with four participants, reveal that infidelity within a marriage leads to feelings of anger, disappointment, and negative self-perceptions, such as feeling unwanted or unworthy and a loss of motivation to live with enthusiasm. Social support and religiosity were identified as critical factors in rebuilding the self-concept of victims of infidelity. Although religiosity does not instantly eliminate emotional pain, it serves as a significant source of strength, calm, and hope in the process of healing emotional wounds. Recovery from this emotional pain is not an easy process. Social support encompasses assistance in self-acceptance, emotional recovery, and the reconstruction of self-identity. Religiosity fosters self-awareness and reflection, helping individuals shift their focus from worldly concerns to spirituality and ultimate life goals. This facilitates adaptation accompanied by feelings of comfort, tranquility, optimism, and gratitude. Religiosity and social support are perceived as enhancing psychological well-being, providing emotional support, and helping individuals face life’s challenges with greater resilience.
Integrating Evolutionary Algorithms and Mathematical Modeling for Efficient Neural Network Optimization
Authors:   Dougherty Valley High School, United States, Gupta Arnav , Sharma Ananya ,   University of Wisconsin, United States, Li Wei Chen ,   The Harker School, United States, Ravi Mehta ,   The Harker School, United States
Published: December 2024

Optimizing neural network architectures presents significant challenges due to the vast search spaces and computational
costs involved. This study explores the integration of evolutionary algorithms (EAs) and mathematical modeling techniques
to enhance neural network optimization. We propose a novel framework combining EAs with dimensionality reduction,
surrogate modeling, and hybrid optimization strategies to reduce computational complexity and improve performance.
Our results demonstrate that the adapted EAs significantly increase accuracy and F1-scores while reducing the number of
generations required for convergence. The hybrid approach, combining EAs with local search techniques, achieves superior
performance and robustness across various datasets. These findings provide a foundational basis for future research in
advanced optimization methods for neural networks
Data & AI for Industrial Application
Authors:   MBDA Italia SpA, via Carlo Calosi, Bacoli, 80070, Italy, Angelino Antimo
Published: December 2024

The use of Artificial Intelligence in the Industry can lead to recovery of efficiency for industrial processes (such as reduce scrap
and rework rate, increase throughput time), and this can carry competitive advantages. Nevertheless, to correctly deploy artificial
intelligence projects it is needed to have connectivity and quality data. Both are enabling factors for AI projects, and industries
must put in place processes to reach them before to start the AI journey.
SURİYELİ VE UKRAYNALI GÖÇMEN ALGISI ÜZERİNE İNGİLİZ BASININDAN BİR ÖRNEK: THE DAİLY EXPRESS GAZETESİ
Authors: Karakaş A. Vildan , Bayar Rüya , Özdemir Mehmet , Yılmaz Mutlu
Published: December 2024

Uluslararası göçmen haberlerinin Batı medyasına yansıyan aktarımları, uzun süredir kamuoyunda tartışılan bir konudur. Tartışmalar arasında göçmenlerin ayrıştırıldığı ve çifte standartlı bir dil kullanıldığı olguları hâkimdir. Bu çalışma ile yakın tarihli iki zorunlu göç örneği olan Suriyeli ve Ukraynalı göçmenlerin İngiliz medyasında nasıl ve hangi algısal temsillerle aktarıldığı ve bu algıların her iki göçmen grubu arasında ne gibi farklılıklar oluşturduğu ortaya konmaya çalışılmıştır. Popüler jeopolitik olan bu çalışma ile İngiliz medyasından seçilen (göçmen karşıtı bir yazılı basın örneği olarak sunulması nedeniyle) The Daily Express gazetesinin Suriyeli ve Ukraynalı göçmen haberleri eleştirel jeopolitik bakış açısıyla analiz edilmiştir. Elde edilen bulgular, Suriyeli ve Ukraynalı göçmenler tarafından İngiltere’ye gerçekleştirilen göç olayının tanımı, Suriyeli ve Ukraynalı göçmenlerin kimliksel tanımı, Suriyeli ve Ukraynalı göçmenler için İngiltere’nin nasıl konumlandırıldığı ve son olarak Suriyeli ve Ukraynalı göçmenler için yapılması gerekenler şeklinde kategorilere ayrılmıştır. Çalışmada elde edilen bulgular ışığında Ukraynalı kimliğinin İngilizlere daha yakın ve yardıma daha layık kimseler (masum, savunmasız ve gerçek mülteci kavramlarının varlığı nedeniyle) olarak sunulduğu, buna rağmen Orta Doğu kökenli Suriyeli kimliğinin ise Batı değerlerine adapte olamayacağı endişesinin yanında İngiliz kültürüne yönelik bir tehdit oluşturabileceği (saldırgan ve şüpheli kavramlarının kullanılması) olgusunun hâkim olduğu sonucuna varılmıştır.
DİKKAT, BİLİŞSEL KONTROL VE UYUMLULUK ORANI ETKİLERİ
Authors: Bozkurt Özge
Published: December 2024

Çok eski yıllardan beri düşünürlerin ilgisini çeken dikkat kavramı, psikolojinin modern bir bilim alanı olarak ortaya çıkması ile birlikte deneysel yöntemlerle araştırılmaya başlanmıştır. İlk dikkat kuramları dikkatin temel özelliklerinden seçici olma ve sınırlı kapasiteye sahip olma konularına odaklanmıştır. Sonraki yıllarda bilgi teknolojilerinin de gelişimi ile birlikte insan zihninin tıpkı bilgisayarlar gibi bir bilgi işleme mekanizmasına sahip olduğu görüşü benimsemiş ve bu mekanizmada sisteme giren bilgilerin akışını, dolayısıyla dikkati, kontrol eden bir sisteme ihtiyaç duyulmuştur. Bu kontrol sistemi ‘bilişsel kontrol’ olarak adlandırılmış ve bilgi işleme sisteminin en önemli parçalarından biri olarak kabul edilmiştir. Bu derlemenin amacı da kontrol alanında kullanılan davranışsal yöntemleri ve modelleri gözden geçirip bir araya getirerek, alanyazınındaki boşluklara ve kapsayıcı bir kuramın eksikliğine dikkat çekmektir. Bilişsel kontrolü konu alan ilk modeller kontrollü ve otomatik davranışların ayrımına odaklanmış ve bu davranışların kendilerine has özelliklerini ortaya koymuşlardır. Takip eden modellerde ve daha güncel modellerde ise zihinde bulunan denetleyici birimler aracılığı ile kontrolün ne zaman ve nereye uygulanacağı konusuna odaklanılmıştır. Bilişsel kontrolü ölçmek için ise deneysel olarak uygulanan Stroop, flanker vb. çatışma görevleri kullanılmıştır. Bu görevler aracılığı ile bilişsel kontrol mekanizmalarını aydınlatan pek çok etki ortaya çıkarılmıştır. Bu etkilerin en önemlilerinden birisi uyumluluk oranı etkileridir. Uyumluluk oranı etkileri çeşitli şekillerde değişimlenerek yeni deneysel yöntemler geliştirilmiş ve bu yöntemler sayesinde dikkatin proaktif, reaktif ve bağlama bağlı şekilde kontrol edilebildiği ortaya çıkarılmıştır. Bu etkiler ile birlikte kontrol modelleri güncellenmiş ve yeni kavramsal çerçeveler ortaya çıkarılmıştır. Yine de tüm bu etkileri kapsamlı şekilde açıklayabilen bir model henüz ortaya konmamış olup, alanyazınında halen çözülmesi gereken çeşitli problemler bulunmaktadır.
TOPLANMA ALANLARI OLARAK YEŞİL ALANLAR VE PARKLAR: ARAŞTIRMALARA DAYALI BİR BAKIŞ
Authors: Önal Sibel
Published: December 2024

Ülkemizde meydana gelen deprem ve sellerde hem can hem de mal kaybı gerçekleşmektedir. Bu afetler ardından afetzedelerin barınma, hijyen gibi hayati ihtiyaçlarının karşılanmasında ilk durak toplanma alanlarıdır. Afetler sırasında ​​veya sonrasında açık ve yeşil alanlar ile parklar toplanma alanı olarak kullanılmaktadır. İhtiyaçları karşılaması beklenen toplanma alanlarının planlanması ​​nüfusun ve yapılı alanların yoğunluğuna dayalı olarak yapılmalıdır. Depremlerden sonra binaların yıkılmasıyla ​​hem toplanma alanı olarak belirlenmiş olan alanlar kullanılamaz hale gelmekte hem de ulaşım ağları zarar görebilmektedir. Bu nedenle toplanma alanlarının belirlenmesinde kolay erişilebilirliği, kapasitesi, altyapısı göz önünde bulundurulmalıdır. Mevcut çalışma, temelde toplanma alanlarını konu edinmiş olan araştırmaların bulguları, sonuçları ve önerilerini ele almaktadır. Yapılan araştırmalar, kentlerdeki yeşil alanlar ve parkların afet sonrası toplanma alanı olarak yeterli olup olmadıklarını tartışırken bir yandan da betonlaşma yüzünden açık alanların azalmasına vurgu yapmaktadır. Araştırmaların sonuçları, toplanma alanlarının nüfusa oranla yetersizliğinin yanı sıra kimi kentlerin her mahallesinde mevcut olmadıklarını göstermektedir. Toplanma alanlarının yetersizlikleri ülke genelinde benzerdir. Araştırmaların ortak önerileri, toplanma alanlarının eksiklerin belirlenerek giderilmesi ve nüfusa oranla yetersiz olan alanların tespit edilerek yeni alanların oluşturulmasıdır. ​​Afet ardından akla gelen ilk şey, güvenli hissetmek için açık alanlarda, parklarda bir araya gelmektir. Kentler ve kent sakinleri için destek sistemi olarak hizmet eden bu alanların yetersizlik durumu afete hazır olmamayla eşdeğerdir.
ALL THE THINGS WE NEVER SAID THROUGH THE LENS OF NARRATIVE EMPATHY
Authors: Demir Nalan , Uysal Mehmet Başak
Published: December 2024

The study examines Yasmin Rahman's young adult novel, All The Things We Never Said, from the perspective of narrative empathy. The work centres around the survival challenges faced by three young individuals: Cara, Olivia, and Mahreen. Cara is rendered immobile as a result of her father's death in a tragic incident, and thereafter manifests symptoms indicative of Post-Traumatic Stress Disorder (PTSD). Olivia is compelled to conceal her mother’s lover's act of abuse in order to ensure her own survival, while Mahreen struggles with the challenges posed by anxiety and depression. The story closes with their relationship progressing from an initial endeavour to assist one another in dying to a strong friendship that promotes reciprocal healing. The novel's narrative strategies were examined within the framework of narrative empathy theory to understand how they evoke empathic responses. The analysis focuses on the point of view, embodied narration, and representation of empathy in the novel.
Z dymem pożarów... = Ułłu titinbe...
Authors: Ujejski Kornel , Abrahamowicz Zachariasz
Published: December 2024

Słowa pieśni odnoszące się do rzezi galicyjskiej Ujejski napisał w 1846 r. do muzyki skomponowanej przez Józefa Nikorowicza. Utwór stał się popularny w czasie Wiosny Ludów, pełniąc zwłaszcza w zaborze austriackim rolę polskiego hymnu. Przekład na język karaimski opublikował po raz pierwszy w 1933 r. Aleksander Mardkowicz na łamach „Karaj Awazy”.
Penerapan Metode First In First Out (FIFO) Dalam Mengontrol Persediaan Barang
Authors: Sihombing Aland Polma Naek , Wandana Jeri , Indra Hamdi
Published: December 2024

Kegiatan mengontrol persediaan barang harus dilakukan agar tidak kehabisan stok barang, Mini Market Diakonia masih melihat catatan stok setiap harinya yang tersedia sehingga membutuhkan waktu yang lama dalam membuat laporan stok barang digudang, begitu juga barang yang keluar dari gudang ke toko dicatat secara manual kedalam sebuah kertas atau buku yang mengakibatkan waktu yang lama dalam membuat laporan barang keluar serta kesalahan dalam pencatatan sering terjadi. Hambatan dan kendala lain yaitu barang yang keluar tidak sesuai dengan barang yang masuk dahulu sehingga banyak ditemui barang yang telah lama masih tersimpan digudang, akibatnya barang tersebut kadaluarsa dan tidak dapat dijual lagi. Agar permasalahan tersebut dapat diatasi maka perlu adanya sistem komputerisasi yang dapat mengolah data pada persediaan barang yang ada digudang atau tempat penyimpanan. Sistem dibuat menggunakan Metode First In First Out (FIFO) yang bertujuan agar barang yang lebih dahulu masuk akan lebih dahulu terjual sehingga tidak ada barang yang kadaluarsa.
Penerapan Sistem Anggaran Di Badan Perencanaan Pembangunan Daerah "BAPPEDA" Kantor Walikota Medan Berbasis Web
Authors: Saputra Yogi , Dhany Hanna Willa , Perwitasari Ika Devi
Published: December 2024

Penelitian ini bertujuan untuk menganalisis penerapan sistem anggaran berbasis web di Badan Perencanaan Pembangunan Daerah (BAPPEDA) Kantor Walikota Medan. Sistem ini diharapkan dapat meningkatkan efisiensi, transparansi, dan akuntabilitas dalam pengelolaan anggaran pembangunan daerah. Penelitian menggunakan pendekatan deskriptif kualitatif dengan metode pengumpulan data melalui wawancara mendalam, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa penerapan sistem berbasis web di BAPPEDA Kota Medan memberikan manfaat signifikan, antara lain percepatan proses penyusunan dan pengajuan anggaran, peningkatan transparansi melalui pelacakan data secara real-time, serta dokumentasi digital yang mendukung akuntabilitas. Namun, penelitian juga menemukan kendala, seperti keterbatasan infrastruktur teknologi, resistensi pengguna terhadap perubahan, dan kebutuhan perawatan sistem yang memadai. Meskipun demikian, dengan dukungan pelatihan intensif, penguatan infrastruktur, dan komitmen pimpinan, sistem ini mampu memberikan kontribusi besar terhadap reformasi birokrasi di Kota Medan. Penelitian ini menyimpulkan bahwa sistem anggaran berbasis web dapat menjadi model efektif bagi pengelolaan anggaran di instansi pemerintah daerah lainnya.
Metodologias ativas no ensino de Biologia: O impacto da sequência didática investigativa no ensino sobre serpentes
Authors: Linhares Luciana Fernandes , Apolinário Marisa de Oliveira , Nóbrega Kayo César Araújo da
Published: December 2024

Este estudo teve como objetivo avaliar o impacto da aplicação de Sequências Didáticas Investigativas e Metodologias Ativas na aprendizagem sobre serpentes, em uma turma da 2ª série do Ensino Médio em uma escola pública de Curral de Cima, Paraíba. Foram desenvolvidas três sequências didáticas investigativas, aplicadas a 31 estudantes da segunda série do ensino médio em uma escola pública na Paraíba. As estratégias desenvolvidas incluíram pesquisas em grupo, discussões, criação de materiais educativos e uso de ferramentas digitais, o que proporcionou aos alunos uma participação ativa no processo de aprendizagem. Os resultados mostraram que essas atividades não só aumentaram a compreensão dos alunos sobre os ofídios, mas também despertaram o interesse pelo tema e uma maior responsabilidade pelo próprio aprendizado, além de fortalecer sua conscientização sobre a importância da conservação das serpentes. Em conclusão, o estudo evidenciou que as metodologias ativas, ao incentivarem uma abordagem investigativa e participativa, não apenas ampliaram o entendimento sobre o tema, mas também cultivaram o pensamento crítico e a curiosidade científica, contribuindo para a formação de uma consciência ambiental mais profunda e conectada ao cotidiano dos estudantes.
Saúde mental do estudante de Medicina: Diálogos entre contextos e determinantes sociais na ótica da Medicina de Família
Authors: Morcerf Cely Carolyne Pontes , Marques João Mazzoncini de Azevedo
Published: December 2024

O processo de formação do estudante de medicina dentro das escolas médicas é repleto por marcantes fases de transição, aumentando o nível de ansiedade e de necessidades constantes de readaptações do aluno, buscando uma sensação de pertencimento em um meio ambiente, dentro de grupos sociais e principalmente pela busca intrínseca em concluir etapas e adquirir competências e habilidades necessárias para o objetivo de ser bem sucedido em um meio acadêmico marcado pela idealização de sucesso da gloriosa figura imaginária do médico formado. O presente trabalho objetiva realizar uma análise crítica de conceitos inerentes à temática da saúde mental do estudante de medicina sob a perspectiva de discussão com um relato de experiência de uma residente de medicina de família e comunidade auxiliando na contribuição com atividades de ensino com alunos de medicina dos ciclos básico e clínico de uma escola médica no interior de São Paulo. O relato é associado a uma revisão narrativa reflexiva sobre o tema. Verifica-se que é essencial ter uma maior ampliação do trabalho da medicina de família e comunidade na criação de formas de apoio e acompanhamento ao estudante de graduação, em uma perspectiva de abordagem centrada na pessoa e integral, capaz de identificar e tratar problemas em saúde mental ocasionados pelo alto impacto de determinantes sociais presentes no curso de medicina sobre a saúde física e mental do estudante, em uma visão integrativa.
Edema Tardio Intermitente Persistente (ETIP) após o uso de ácido hialurônico - desafios e abordagens clínica: Um relato de caso
Authors: Fermín Ureña Jose Rafael , Sousa Dennis Dinelly de , Farias Italo de Lima , Castro Núñez Eladio Antonio , Chihara Leticia Liana , Sotomayor Zela Ximena Virgina , Sant´Ana Eduardo
Published: December 2024

O Ácido Hialurônico (AH) é muito utilizado no mundo da harmonização facial, seu uso requer alto conhecimento da anatomia e da técnica a ser utilizada no momento de sua aplicação, embora seja um material seguro, pode gerar complicações. Neste contexto, o objetivo do presente artigo é apresentar um relato de caso clínico de uma paciente de 29 anos de idade que desenvolveu Edema Persistente Intermitente Tardio (ETIP), que apresentou esse quadro um ano após realizar preenchimento labial com AH, desencadeado durante um episódio de gripe. O tratamento proposto foi sessões de dexametasona um glicocorticoide sintético com potente ação anti-inflamatória e fotobiomodulação, técnica que utiliza luz de baixa intensidade para estimular a regeneração tecidual. O tratamento mostrou-se eficaz, com resolução completa em sete dias e sem recidiva após um ano de acompanhamento. O artigo destaca a importância do diagnóstico preciso e manejo adequado de complicações tardias do AH, propondo estratégias terapêuticas eficazes que visam garantindo maior segurança e eficácia nos procedimentos estéticos.
GİNSBURG'UN SİGORTA TEORİSİ IŞIĞINDA ETİYOPYA'NIN SİYASİ DENETİM SİSTEMİ: SİHİR SİHİRBAZA DÖNÜŞTÜĞÜNDE
Authors: Yimam Habib Yesuf
Published: December 2024

Bu makale, Etiyopya'nın siyasi denetim sistemini ve Etiyopya Halkının Devrimci Demokratik Cephesi (EPRDF) altındaki evrimini Tom Ginsburg'un sigorta teorisi merceğinden incelemektedir. Bir zamanlar Etiyopya'daki baskın siyasi güç olan Tigray Halk Kurtuluş Cephesi (TPLF), ülkenin siyasi ve anayasal çerçevesinin oluşturulmasında çok önemli bir rol oynamıştır. Ancak, siyasi dinamikler değiştikçe, TPLF liderliğindeki EPRDF tarafından tasarlanan anayasal denetim sistemi onlara karşı bir silah haline dönüştürmüştür. Bu çalışma, TPLF'nin etkili ve bağımsız bir yargısal denetim mekanizması oluşturamamasının onu, İktidar Refah Partisi’ne (PP) geçtiğinde, nasıl siyasi olarak savunmasız hale getirdiğini ve bunun klasik bir “sihrin sihirbaza dönüşmesi” durumuyla sonuçlandığını Ginsburg'un “sigorta teorisi” çerçevesinde incelemektedir. Bu vaka, siyasi elitlerin uzun vadeli kurumsal sigorta yerine kısa vadeli hakimiyete öncelik vermesinin risklerini altını vurgulamaktadır. Ayrıca, bu makale TPLF liderliğindeki EPRDF'nin anayasal otoriterlik rejimi altında meşruiyetini nasıl koruduğunu ve otoriter kontrolü pekiştirmek için zayıf anayasal denetim biçimi de dahil olmak üzere anayasal hükümleri ve yapıları nasıl manipüle ettiğini incelemektedir.
Engraftment of self-renewing endometrial epithelial organoids promotes endometrial regeneration by differentiating into functional glands in rats
Authors: Ma Yana , Qian Jingjing , Xu Xin , Wei Cheng , Wang Minyuan , Zhang Peipei , Chen Sijia , Zhang Lingyan , Zhang Yanling , Wang Yanpeng , Xu Wenzhi , Liu Mengying , Lin Xiaona
Published: December 2024

Introduction

Extensive trauma frequently disrupts endometrial regeneration by diminishing endometrial stem cells/progenitor cells, affecting female fertility. While bone marrow mesenchymal stem cell (BMSC) transplantation has been suggested as an approach to address endometrial injury, it comes with certain limitations. Recent advancements in endometrial epithelial organoids (EEOs) have displayed encouraging potential for endometrial regeneration. Therefore, this study aims to explore whether EEOs surpass BMSCs in their ability to repair injured endometrium and to examine whether the restoration process involves the integration of EEOs into the endometrial tissue of the recipient.

Methods

We developed rat EEOs (rEEOs) mimicking the features of the rat endometrium. Subsequently, we created a rat model of endometrial injury to compare the effects of rEEOs and rat BMSCs (rBMSCs) on endometrial regeneration and reproductive recovery. Bulk RNA-sequencing analysis was conducted to further investigate the capacity of rEEOs for endometrial regeneration and to identify discrepancies between rEEOs and rBMSCs. Additionally, to track the fate of the transplanted cells in vivo, we transplanted green fluorescent protein (GFP) -labelled rEEOs or red fluorescent protein (RFP) -labelled rBMSCs.

Results

In a rat model of endometrial injury, we observed that fertility recovery in rats transplanted with rEEOs was more comparable to that of normal rats than in those treated with rBMSC. rEEOs possess a high concentration of endometrial epithelial stem/progenitor cells and secrete vascular endothelial growth factor (VEGF)-A to promote endometrial neovascularization. Significantly, we observed that cells from GFP-labelled rEEOs could integrate and differentiate into functional glands within the injured endometrium of recipient rats.

Discussion

EEOs offer a transformative approach to address the challenges of endometrial trauma. Their remarkable regenerative potential holds promise for the restoration of damaged endometrium. As we venture into the future, the concept of utilizing patient-specific EEOs for transplantation emerges as a tantalizing prospect. However, the EEOs in our experiments were mainly cultured in Matrigel, which has barriers to clinical translation as a biomaterial, a new biomaterial to be explored. Secondly, our experiments have been successful only in rat models, and more efforts need to be made before clinical translation.
Influence of acupuncture intensity on analgesic effects in AA rat models
Authors: Wang Yi-Xuan , Liu Yu-Hang , Zhang Zi-Liang , Qiao Xuan , Li Ying-Chen , Ren Liu-Jie , Ding Guang-Hong , Yao Wei , Yu Yi
Published: December 2024

Objective

To investigate the influence of acupuncture lifting-thrusting frequency and amplitude on the analgesic effects, and its correlation with mast cell degranulation.

Methods

Acute adjuvant arthritis (AA) rat models were employed. Robot-arm aided lifting-thrusting acupuncture therapy was conducted with various frequencies (ranging from 0.5 to 4 Hz) and amplitudes (ranging from 0.5 to 2.0 mm). The rats’ pain thresholds were measured multiple times before and after the therapy, and the analgesic effects were evaluated using the pain threshold recovery rate (PTRR), a normalized index. The mast cell degranulation rate (MCdR) at the acupoint was calculated, and a correlation analysis between PTRR and MCdR was performed.

Results

Acupuncture therapy partially restored the pain threshold affected by arthritis. The analgesic effects were influenced by stimulus frequency and amplitude, with best outcomes occurring at an intermediate optimal frequency of 1.0 Hz and amplitude of 1.0–1.5 mm. Similarly, the MCdR peaked at the optimal frequency and amplitude.

Conclusion

Our animal experiment suggests that optimal analgesic effects can be achieved with stimulation at an optimal intensity. This intensity-effect correlation appears to originate from mast cell activation rates under different mechanical stimulus.
The role of sphingolipid rheostat in the adult-type diffuse glioma pathogenesis
Authors: Karmelić Ivana , Jurilj Sajko Mia , Sajko Tomislav , Rotim Krešimir , Fabris Dragana
Published: December 2024

Gliomas are highly aggressive primary brain tumors, with glioblastoma multiforme being the most severe and the most common one. Aberrations in sphingolipid metabolism are a hallmark of glioma cells. The sphingolipid rheostat represents the balance between the pro-apoptotic ceramide and pro-survival sphingosine-1-phosphate (S1P), and in gliomas it is shifted toward cell survival and proliferation, promoting gliomas’ aggressiveness, cellular migration, metastasis, and invasiveness. The sphingolipid rheostat can be altered by targeting enzymes that directly or indirectly affect the ratio of ceramide to S1P, leading to increased ceramide or decreased S1P levels. Targeting the sphingolipid rheostat offers a potential therapeutic pathway for glioma treatment which can be considered through reducing S1P levels or modulating S1P receptors to reduce cell proliferation, as well as through increasing ceramide levels to induce apoptosis in glioma cells. Although the practical translation into clinical therapy is still missing, sphingolipid rheostat targeting in gliomas has been of great research interest in recent years with several interesting achievements in the glioma therapy approach, offering hope for patients suffering from these vicious malignancies.
Electronic structure of metal oxide dications with ammonia ligands and their reactivity towards the selective conversion of methane to methanol
Authors: Claveau Emily E. , Miliordos Evangelos
Published: December 2024

High-level quantum chemical calculations are performed for the (NH3)MO2+ and (NH3)5MO2+ species (M = Ti-Cu), extending our previous work on the bare MO2+ ions. The potential energy curves along the M-O distance are constructed for the ground and multiple excited electronic states of (NH3)MO2+ and are compared to those of MO2+. We see that ammonia stabilizes the oxo states (M4+O2−) over the oxyl (M3+O⋅−) ones. This trend is intensified in the (NH3)5MO2+ species. We then examined the reaction of the latter species with both methane and methanol. We find that the oxyl states activate a C-H bond easily with barriers smaller than 10 kcal/mol across all first-row transition metals, while the barriers for the oxo states start from about 50 kcal/mol for M = Ti and decrease linearly to 10 kcal/mol going toward M = Ni. This is attributed to the increasing spin density on the oxygen atom observed for the oxo states. The most important finding is that the formation of hydrogen bonds between the OH group of methanol and the N-H bonds of the ammonia ligands increases the activation barriers for methanol considerably, making them comparable to and slightly higher than those of methane. This finding suggests a new strategy to slow the oxidation of methanol, leading to the long-desired higher methane-to-methanol selectivity.
Enhancing insectivorous bat activity through sound manipulation and assessing the contribution of small gaps in windbreaks in the hyper-arid Arava desert
Authors: Einav Adi , Giladi Itamar , Schäckermann Jessica , Korine Carmi
Published: December 2024

Insectivorous bats are an important group of natural enemies that use echolocation for communication, navigation, and foraging. While foraging, bats often eavesdrop on calls from other foraging individuals and are attracted to them as these indicate prey abundance. In addition, they use hedgerows such as tree lines in agroecosystems for commuting and foraging. In the present study, we employed two approaches to enhance the activity of desert-dwelling bats in fields of melon, pumpkin and onion in the hyper-arid Arava desert, Israel. We predicted that both approaches will enhance the activity of the bats in these agricultural fields. We broadcasted playbacks of echolocation calls of two common desert bats, Hypsugo ariel and Eptesicus bottae over the crop fields as a direct means and used gaps in windbreak lines made of planted trees Tamarix spp. as indirect means. Playback manipulation had differing results between the two species. The activity of H. ariel was initially higher in the control plot, but as broadcasting continued, the manipulated plot exhibited significantly higher activity over onion fields. In contrast, the activity of E. bottae declined over Cucurbit fields in the manipulated plots. These differences may reflect differences between the species in the level of sociality while foraging. The testing of the indirect approach showed that total bat activity and feeding buzzes ratio were significantly higher in small windbreak gaps compared to plots with continues tree line. Our results indicate the potential and the limitations of enhancing bat activity by broadcasting echolocation calls in open crop fields and the importance of landscape features which increase the heterogeneity of the crop fields to attract natural enemies in Conservation Biological Control.
Post-fire negative relationship between a native tree and an invasive pine at the Coastal Maulino Forest in Central Chile
Authors: Escobedo Víctor M. , Gómez Persy , Molina-Montenegro Marco A. , Acuña-Rodríguez Ian S.
Published: December 2024

Coastal Maulino Forest, a biodiversity hotspot, is increasingly threatened by frequent and higher-severity wildfires. Endangered tree species, including Nothofagus spp., inhabit small, isolated native forest fragments surrounded by extensive Pinus radiata plantations, a non-native species that often colonises fire-affected areas. However, the seedling density of the native Chilean wineberry, Aristotelia chilensis, negatively correlates with the abundance of P. radiata seedlings in post-fire areas. This pattern emerged across areas burned at varying fire severities, sampled 8 and 24 months following the 2017 “Las Máquinas” megafire in Chile. The high proportion of plots lacking P. radiata seedlings, coupled with this negative relationship, suggests that A. chilensis may play a role in limiting P. radiata invasion. The negative relationship was most pronounced in areas with moderate fire severity, likely reflecting differences in shade tolerance between the species. While A. chilensis, a light-demanding species with some shade tolerance, can persist in partially shaded environments, P. radiata, a strictly light-demanding species, struggles under significant shade. In low-severity areas, no significant relationship was observed since the substantial native canopy remaining likely limits P. radiata establishment by shading. Conversely, in high-severity fire areas, the absence of a significant relationship might result from the detrimental effects on both species, including potential microbiome dependence for A. chilensis. Given the successful establishment of A. chilensis at low fire severity, enhancing its post-fire recruitment, particularly in moderately burned areas, could be a valuable strategy for mitigating P. radiata invasion and restoring fire-affected Mediterranean ecosystems.
Ring finger protein 5 mediates STING degradation through ubiquitinating K135 and K155 in a teleost fish
Authors: Qin Xiaowei , Li Chuanrui , Liang Mincong , Qian Zhen , You Yanlin , Weng Shaoping , He Jianguo , Guo Changjun
Published: December 2024

Stimulator of interferon genes (STING) is a key connector protein in interferon (IFN) signaling, crucial for IFN induction during the activation of antiviral innate immunity. In mammals, ring finger protein 5 (RNF5) functions as an E3 ubiquitin ligase, mediating STING regulation through K150 ubiquitylation to prevent excessive IFN production. However, the mechanisms underlying RNF5’s regulation of STING in teleost fish remain unknown. This study investigated the regulatory role of the mandarin fish (Siniperca chuatsi) RNF5 (scRNF5) in the STING-mediated antiviral immune response and identified the specific regulatory sites on scSTING. Furthermore, an examination of scRNF5 expression patterns in virus-infected cells revealed its responsiveness to mandarin fish ranavirus (MRV) infection. The ectopic expression of scRNF5 suppressed scSTING-mediated IFN signaling and facilitated MRV replication. Co-immunoprecipitation experiments indicated an interaction between scRNF5 and scSTING. The further experiments demonstrated that scRNF5 exerted its inhibitory effect by promoting the degradation of scSTING, which was observed to be blocked by MG132 treatment. Ubiquitination assays with various scSTING mutants showed that scRNF5 catalyzed the ubiquitination of scSTING at K135 and K155 residues. Furthermore, we provided evidence that scRNF5 significantly attenuated scSTING-dependent antiviral immunity by targeting negative regulators within the scSTING signaling cascade. This study underscored that RNF5 negatively regulated the STING-mediated IFN signaling pathway in mandarin fish, attenuated STING’s antiviral activity, and facilitated STING degradation via the ubiquitin-proteasome pathway at two novel lysine sites (K135 and K155). Our work offered valuable insights into the regulatory mechanisms of STING-mediated signaling in teleost fish, paving the way for further research.
A few-shot oil spill segmentation network guided by multi-scale feature similarity modeling
Authors: Shi Lingfei , Wei Xianhu , Yang Kun , Chen Gong
Published: December 2024

Segmentation of oil spills with few-shot samples using UAV optical and SAR images is crucial for enhancing the efficiency of oil spill monitoring. Current oil spill semantic segmentation predominantly relies on SAR images, rendering it relatively data-dependent. We propose a flexible and scalable few-shot oil spill segmentation network that transitions from UAV optical images to SAR images based on the image similarity of oil spill regions in both types of images. Specifically, we introduce an Adaptive Feature Enhancement Module (AFEM) between the support set branch and the query set branch. This module leverages the precise oil spill information from the UAV optical image support set to derive initial oil spill templates and subsequently refines and updates the query oil spill templates through training to guide the segmentation of SAR oil spills with limited samples. Additionally, to fully exploit information from both low and high-level features, we design a Feature Fusion Module (FFM) to merge these features. Finally, the experimental results demonstrate the effectiveness of our network in enhancing the performance of UAV optical-to-SAR oil spill segmentation with few samples. Notably, the SAR oil spill detection accuracy reaches 75.88% in 5-shot experiments, representing an average improvement of 5.3% over the optimal baseline model accuracy.
Efficacy and safety of acupuncture in the treatment of Meniere’s disease: a systematic review and meta-analysis
Authors: Tang Mingjie , Li Yinghong , Lu Man , Zhang Tianchen , Ge Yanhao , Han Jie , Tang Jiqin , Chen Zhaoming
Published: December 2024

Background

Meniere’s disease (MD) is an idiopathic chronic inner ear disease that seriously impacts patients’ physical and mental health. Medications may be effective for a proportion of patients, and additional effective treatments are still needed. This review aimed to evaluate the efficacy of acupuncture treatment for MD.

Methods

Eight databases were systematically searched from their inception to June 1, 2024, to identify randomized clinical trials on acupuncture treatment for MD. The Cochrane Risk of Bias 2.0 tool was used to assess the risk of bias in included studies, and meta-analysis was conducted by RevMan 5.4 and Stata 16.0 software.

Results

Six studies were included in this review. The treatment group received acupuncture or acupuncture combined with Western medicine, while the control group was treated with Western medicine. The treatment group was superior to the control group in terms of efficacy rate (RR: 1.20; 95% CI: 1.11–1.29; p < 0.0001). The treatment group reduced dizziness handicap inventory (DHI) (MD: 6.94; 95% CI: 1.58–12.30; p = 0.01), tinnitus handicap inventory (THI) (MD: 6.52; 95% CI: 0.77–12.27; p = 0.03), stuffy ear visual analog scale (VAS) (MD: 0.87; 95% CI: 0.54–1.20; p < 0.0001) and pure tone audiometry score (MD: 6.57; 95% CI: 5.62–7.51; p < 0.0001) to a greater degree than those of the control group. There were some methodological shortcomings in the included studies, including failure to implement blinding, inappropriate outcome measures, and heterogeneity of clinical interventions, such as selected acupoints, acupuncture sessions, and therapist techniques.

Conclusion

Acupuncture may improve the symptoms of vertigo, tinnitus, ear fullness and hearing loss in patients with MD. However, due to the lack of literature included in this study and methodological weaknesses like randomization, blinding, and clinical heterogeneity, more well-designed long-term follow-up RCTs are needed to evaluate the efficacy and safety of acupuncture.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/(CRD42024549261).
Genomic analysis of Salmonella isolated from surface water and animal sources in Chile reveals new T6SS effector protein candidates
Authors: Amaya Fernando A. , Blondel Carlos J. , Reyes-Méndez Felipe , Rivera Dácil , Moreno-Switt Andrea , Toro Magaly , Badilla Consuelo , Santiviago Carlos A. , Pezoa David
Published: December 2024

Type VI Secretion Systems (T6SS), widely distributed in Gram-negative bacteria, contribute to interbacterial competition and pathogenesis through the translocation of effector proteins to target cells. Salmonella harbor 5 pathogenicity islands encoding T6SS (SPI-6, SPI-19, SPI-20, SPI-21 and SPI-22), in which a limited number of effector proteins have been identified. Previous analyses by our group focused on the identification of candidate T6SS effectors and cognate immunity proteins in Salmonella genomes deposited in public databases. In this study, the analysis was centered on Salmonella isolates obtained from environmental sources in Chile. To this end, bioinformatics and comparative genomics analyses were performed using 695 genomes of Salmonella isolates representing 44 serotypes obtained from surface water and animal sources in Chile to identify new T6SS effector proteins. First, T6SS gene clusters were identified using the SecreT6 server. This analysis revealed that most isolates carry the SPI-6 T6SS gene cluster, whereas the SPI-19 and SPI-21 T6SS gene clusters were detected in isolates from a limited number of serotypes. In contrast, the SPI-20 and SPI-22 T6SS gene clusters were not detected. Subsequently, each ORF in the T6SS gene clusters identified was analyzed using bioinformatics tools for effector prediction, identification of immunity proteins and functional biochemical prediction. This analysis detected 20 of the 37 T6SS effector proteins previously reported in Salmonella. In addition, 4 new effector proteins with potential antibacterial activity were identified in SPI-6: 2 Rhs effectors with potential DNase activity (PAAR-RhsA-NucA_B and PAAR-RhsA-GH-E) and 2 effectors with potential RNase activity (PAAR-RhsA-CdiA and RhsA-CdiA). Interestingly, the repertoire of SPI-6 T6SS effectors varies among isolates of the same serotype. In SPI-19, no new effector protein was detected. Of note, some Rhs effectors of SPI-19 and SPI-6 present C-terminal ends with unknown function. The presence of cognate immunity proteins carrying domains present in bona fide immunity proteins suggests that these effectors have antibacterial activity. Finally, two new effectors were identified in SPI-21: one with potential peptidoglycan hydrolase activity and another with potential membrane pore-forming activity. Altogether, our work broadens the repertoire of Salmonella T6SS effector proteins and provides evidence that SPI-6, SPI-19 and SPI-21 T6SS gene clusters harbor a vast array of antibacterial effectors.