bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Comorbidity on the Duration from Symptom Onset to Death in Patients with Coronavirus Disease 2019: A Retrospective Study of 104,753 Cases in Pakistan
Authors: Zhou Haoqi , Wang Jingyuan , Asghar Naseem , Liang Baosheng , Song Qianqian , Zhou Xiaohua
Published: December 2023

(1) Background: The evidence indicates that comorbidities are associated with an increase in the risk of death from coronavirus disease 2019 (COVID-19). It is unclear whether such an association is different for various combinations of chronic disease comorbidities. (2) Methods: From 16 March 2020 to 30 November 2021, 104,753 patients with confirmed COVID-19 from Khyber Pakhtunkhwa Province, Pakistan, were studied to determine the association between comorbidities and the duration from symptom onset to death in patients with COVID-19 by stratifying their comorbidity status. (3) Results: The patients with comorbidities had an 84% (OR, 0.16; 95% CI, 0.14 to 0.17) decrease in the duration from symptom onset to death, as opposed to patients without a comorbidity. Among the patients with only one comorbidity, chronic lung disease (OR, 0.06; 95% CI, 0.03 to 0.09) had a greater impact on the duration from symptom onset to death than hypertension (OR, 0.15; 95% CI, 0.13 to 0.18) or diabetes (OR, 0.15; 95% CI, 0.12 to 0.18). The patients with both hypertension and diabetes had the shortest duration (OR, 0.17; 95% CI, 0.14 to 0.20) among the patients with two comorbidities. (4) Conclusions: Comorbidity yielded significant adverse impacts on the duration from symptom onset to death in COVID-19 patients in Pakistan. The impact varied with different combinations of chronic disease comorbidities in terms of the number and type of comorbidities.
Spatiotemporal Variations of the Frequency–Magnitude Distribution in the 2019 Mw 7.1 Ridgecrest, California, Earthquake Sequence
Authors: Sardeli Eirini , Michas Georgios , Pavlou Kyriaki , Vallianatos Filippos
Published: December 2023

Significant seismic activity has been witnessed in the area of Ridgecrest (Southern California) over the past 40 years, with the largest being the Mw 5.8 event on 20 September 1995. In July 2019, a strong earthquake of Mw 7.1, preceded by a Mw 6.4 foreshock, impacted Ridgecrest. The mainshock triggered thousands of aftershocks that were thoroughly documented along the activated faults. In this study, we analyzed the spatiotemporal variations of the frequency–magnitude distribution in the area of Ridgecrest using the fragment–asperity model derived within the framework of non-extensive statistical physics (NESP), which is well-suited for investigating complex dynamic systems with scale-invariant properties, multi-fractality, and long-range interactions. Analysis was performed for the entire duration, as well as within various time windows during 1981–2022, in order to estimate the qM parameter and to investigate how these variations are related to the dynamic evolution of seismic activity. In addition, we analyzed the spatiotemporal qM value distributions along the activated fault zone during 1981–2019 and during each month after the occurrence of the Mw 7.1 Ridgecrest earthquake. The results indicate a significant increase in the qM parameter when large-magnitude earthquakes occur, suggesting the system’s transition in an out-of-equilibrium phase and its preparation for seismic energy release.
Assessing the Efficacy of Reflective Game Design: A Design-Based Study in Digital Game-Based Learning
Authors: Shaheen Anjuman , Ali Sanam , Fotaris Panagiotis
Published: December 2023

Reflective learning is widely recognised as a highly effective approach to learning. It involves learners in a process wherein they reflect on their past experiences to improve their skills and knowledge. In recent years, there has been growing recognition of the capacity of games to facilitate experiential learning. Therefore, this research aimed to evaluate the effectiveness of integrating reflective design principles into digital game-based learning (GBL). The focus was on assessing the reliability and appropriateness of reflective game design, as well as learner perceptions. This study adopted a participatory design approach, ensuring the active involvement of the target audience across all extensive phases. The research consisted of three main phases. Firstly, reflective learning was integrated into game design to develop the Reflective Game Design (RGD) framework. This development was guided by insights gathered from participants through both a user survey (N = 101) and semi-structured interviews (N = 15). Subsequently, a GBL digital game was developed based on the RGD framework in co-design sessions (N = 6). Finally, a prototype evaluation (N = 56) was conducted to assess the feasibility and practicality of implementing reflective game design within digital GBL contexts. Overall, the RGD approach and the game prototype received positive feedback in terms of engagement, content clarity, the incorporation of reflective game elements, and player immersion. This study contributes to the literature by providing principles and guidelines for RGD, thus offering valuable insights for researchers, educators, and game designers looking to create effective educational games.
BPath-RO: A Performance- and Area-Efficient In Situ Delay Measurement Scheme for Digital IC
Authors: Li Danqing , Liang Huaguo , Zhang Hong , Wang Yue , Yi Maoxiang , Lu Yingchun , Huang Zhengfeng
Published: December 2023

Circuit delays are increasingly sensitive to process, voltage, temperature, and aging (PVTA) variations, severely impacting circuit performance. Accurate measurement of circuit delay is essential. However, the additional hardware structures for measuring circuit delay add to the critical path delay. To address this issue, this paper proposes a bypass-based ring oscillator (BPath-RO) that reduces the impact on the critical path delay by moving the added measurement control structures to the bypass. The proposed measurement scheme requires only two transistors inserted into the critical path, which is more conducive to engineering change order (ECO). Measurement simulation experiments were performed on representative critical paths of the ISCAS’89 s298 and ITC’99 b15 benchmark circuits. The experimental results show that, in comparison with the existing architectures, the Bpath-RO delay measurement scheme improves the circuit performance by an average of 13.81% (s298) and 3.47% (b15) and reduces the hardware overhead by up to 70% for each path.
Attribute-Based Proxy Signature Scheme Supporting Flexible Threshold Predicate for UAV Networks
Authors: He Lei , Gan Yong , Zhang Yanhua
Published: December 2023

Unmanned aerial vehicle (UAV) is an attractive application because of its flexibility and economy. It may use a digital signature scheme to protect commands sent to UAVs. Moreover, the digital signature scheme should guarantee the real-time performance of UAVs executing commands and protect the signer’s privacy. Therefore, we proposed an attribute-based proxy signature (ABPS) scheme supporting flexible threshold predicate for UAV networks and proved its security. It has existential unforgeability under selective-predicate and chosen message attacks (EUF-sP-CMA) and can protect the signer’s privacy. We analyzed its computation costs based on experimental data and communication costs. The analysis results indicate that our ABPS scheme has less computation costs than other ABPS schemes and is at the same level as other ABPS schemes on communication costs.
A Simple and Economical System for Automatic Near-Field Scanning for Power Electronics Converters
Authors: Grasso Sebastiano , Bellinvia Salvatore , Salerno Nunzio , Rizzo Santi Agatino
Published: December 2023

Electromagnetic compatibility issues must be considered from the early steps in the design of electronic devices. A specific topic is the near-field emission generated by the device due to the traces on a printed circuit board and the specific routing. The analysis of near-field emission is essential to detect potential electromagnetic interference with nearby devices. This problem is crucial in high power density applications. Therefore, especially in these applications, it is necessary to optimize the circuit and the layout to minimize the generated noise. The design and construction of systems able to scan volumes to determine the spatial distribution of electrical E and/or magnetic B fields in the near-field region of a device under test is a very complex process. The realization of equipment that explores a given surface at a given distance from the device is easier. The main purpose of this paper is to show how it is possible to build a cheap two-dimensional scanner, starting from simple hardware not explicitly designed for near-field scan operations. The presented firmware and software solution can map, with good accuracy, the spatial distribution of fields B and E on a fixed plan close to the board. Finally, the developed system has been used in a GaN-based bi-directional DC/DC Converter.
A Review of the Resourceful Utilization Status for Decommissioned Power Batteries
Authors: Liu Zhihong , Zhou Tuo , Yang Hairui , Huang Zhong , Zhang Yaning , Zhang Man
Published: December 2023

With the rapid development of the new energy vehicle industry, the number of power battery decommissioning is increasing year by year. The recycling of power batteries is of great significance for protecting the ecological environment, improving the efficiency of resource utilization, and ensuring the sustainable and healthy development of the new energy automobile industry. In this study, the chemical compositions of power batteries were introduced, the technical path and development status of the echelon utilization of decommissioned power batteries were discussed, and the specific steps and challenges of regenerative utilization of decommissioned power batteries were described in detail from two aspects of pyrometallurgy and hydrometallurgy. Combined with the relevant research results, the main methods of the direct regeneration of positive electrode materials were analyzed. Finally, the main development direction and related suggestions for the resource utilization of decommissioned power batteries were put forward.
Experimental Study on the Flow Characteristics of Two-Stage Variable Turbines in a Twin-VGT System
Authors: Peng Qikai , Zhang Zhongjie , Zhou Guangmeng , Dong Surong , Zhao Xumin , Zhang Han , Liu Ruilin , Cai Jun
Published: December 2023

The twin variable geometry turbocharger (VGT) System, through efficient use of exhaust energy, maximizes internal combustion engine (ICE) power, reduces exhaust emissions and improves reliability. However, the internal flow characteristics of the twin-VGT system are greatly affected by the environment. To ensure that the two-stage adjustable supercharged internal combustion engine is efficient in all geographical environments and under all operating conditions, it is necessary to conduct in-depth research on the internal flow characteristics of high- and low-pressure turbines. In this paper, an experimental system of the flow characteristics of a double variable-geometry turbocharging (twin-VGT) system is designed and developed. A two-stage variable turbine flow characteristic test was carried out, focusing on the relationship between the initial rotational velocity of high variable-geometry turbocharging (HVGT) and blade opening in low variable-geometry turbocharging (LVGT). The effects of high- and low-pressure variable-geometry turbocharger (VGT) blade opening on available exhaust energy, expansion ratio distribution, blade velocity ratio, compressor power consumption and isentropic efficiency were studied. The results show that when the available energy of exhaust gas is constant, with the increase in HVGT turbine speed, when the LVGT blade opening decreases by 10%, the low-pressure turbine expansion ratio increases by about 0.23.
A Fitting Method to Characterize the Gaseous Venting Behavior of Lithium–Ion Batteries in a Sealed Chamber during Thermal Runaway
Authors: Li Cheng , Wang Hewu , Shi Chao , Wang Yan , Li Yalun , Ouyang Minggao
Published: December 2023

The venting event of thermal runaway has attracted public attention due to safety issues aroused by frequent fire accidents of new energy vehicles. However, the quantitative description of venting behavior is incomplete for tests in a sealed chamber due to the initial violent injection. In this study, nine types of batteries covering 28 cases in total were employed to investigate the influence of energy density, ambient temperature, pressure, and SOC on the venting behavior, characterized by normalized gas amount; maximum gas releasing rate; and venting durations t50, t90, t95, and t99. Then, a ‘two-point’ fitting method was proposed to modify outcomes concerning real-time gas amounts. The results show that at 100% SOC, the normalized gas amount ranges within 0.075–0.105 mol/Ah for NCM batteries and 0.025–0.035 mol/L for LFP batteries, while the maximum gas releasing rate presents a strongly positive correlation with the capacity of NCM batteries (0.04–0.31 mol/s) and a slight increase for LFP batteries (0.02–0.06 mol/s). Eventually, the three venting patterns were summarized and advanced according to the energy density and SOC of the targeted battery. This research can provide a reference for risk evaluations of the venting process and safety design for structure and pressure relief in battery systems.
Research on Changes in the Phase Shift Angle and Admittance of the Cellulose–Bio-Oil Composite under the Influence of Increasing Moisture during the Long-Term Operation of Power Transformers
Authors: Zukowski Pawel , Kierczynski Konrad , Okal Paweł , Rogalski Przemyslaw , Zenker Marek , Pajak Rafal , Molenda Pawel , Szrot Marek , Koltunowicz Tomasz N.
Published: December 2023

In this study, the temperature–frequency dependencies of the pressboard–bio-oil–water nanoparticle composite’s fundamental parameters—phase shift angle and admittance—were examined using the Frequency Domain Spectroscopy method. Measurements were conducted in a frequency range of 10−4 Hz to 5 × 103 Hz at temperatures ranging from 293.15 K to 343.15 K, with a step of 10 K. The temperature stabilization accuracy was less than ±0.05 K. A total of 15 Arrhenius plots were determined for various phase shift angle values, from which 15 values and the average activation energy of relaxation time were determined. Similarly, the values of the activation energy of admittance relaxation time and the activation energy of admittance were determined. It was established that all three average values are identical within the bounds of uncertainty. Based on 45 values, a generalized activation energy was determined, with a value of ΔW ≈ (1.032 ± 0.0196) eV. Using the generalized activation energy value, the phase shift angle curves determined for all temperatures were recalculated to a temperature of 293.15 K. It was found that after conversion, all curves perfectly overlap. A similar operation was carried out for the frequency dependencies of admittance. In this case, too, the recalculated dependencies perfectly match. This means that the shape of the frequency dependencies of the phase shift angle and admittance depends solely on the moisture content in the pressboard–bio-oil–water nanodrop composite. The position of the curves in doubly logarithmic coordinates depends only on temperature and is determined by the generalized activation energy Using the generalized activation energy determined in this study will allow for the development of accurate methods for estimating moisture content in cellulose insulation of power transformers containing bio-oil. This will contribute to the detection of critical moisture content, which is about 5% by weight, and to the elimination of the risk, associated with such a high moisture content, of catastrophic failure of power transformers.
Impact of Figures of Merit Selection on Hybrid–Electric Regional Aircraft Design and Performance Analysis
Authors: Abu Salem Karim , Palaia Giuseppe , Quarta Alessandro A.
Published: December 2023

The adoption of hybrid–electric propulsion, allowing us to partially replace fuel with batteries and to reduce aircraft in-flight emissions, represents one of the main investigated solutions to mitigate the aviation climate impact. Despite its environmental potential being appealing for a practical application, two main drawbacks limit the actual implementation of this technology: first, the low gravimetric energy density of the batteries restricts hybrid–electric aircraft payload and range capabilities; second, the production of electricity is currently not entirely based on renewable energy sources, hence a non-direct emissions budget may limit the benefit in terms of overall decarbonization. When designing hybrid–electric aircraft, even projecting its actual entry into service in the next decades, it is necessary to take these limitations into account depending on both the more reliable technological forecasts on the development of electric components and on the estimates of electricity production. A proper analysis of the figure of merits related to the operation of such an aircraft, therefore, becomes crucial in assessing the impact related to its introduction into service. In this context, trade-offs between different performance metrics may be needed to efficiently exploit the environmental benefits of such an advanced concept, while limiting the possible drawbacks coming from its utilisation. This paper provides a performance analysis of hybrid–electric aircraft through an assessment of the relevant figures of merit characterizing its operations. In particular, direct and non-direct emissions, climate impact, ground pollution, operating costs, fuel consumption, weight, and a combination of these figures of merit allow us to define a proper development perimeter in which a possible (future) hybrid–electric aircraft can express its maximum potential towards all the aspects of its utilisation. The trade-off analyses provided in this paper allow us to identify more effective paths for the actual development of hybrid–electric aircraft, highlighting the impact of the selected design variables on the performance metrics, and bringing to light also the possible related limitations.
Studies on Air Pollution and Air Quality in Rural and Agricultural Environments: A Systematic Review
Authors: Borghi Francesca , Spinazzè Andrea , De Nardis Nicholas , Straccini Serena , Rovelli Sabrina , Fanti Giacomo , Oxoli Daniele , Cattaneo Andrea , Cavallo Domenico Maria , Brovelli Maria Antonia
Published: December 2023

Studies on air quality in rural environments are fundamental to obtain first-hand data for the determination of base emissions of air pollutants, to assess the impact of rural-specific airborne pollutants, to model pollutant dispersion, and to develop proper pollution mitigation technologies. The literature lacks a systematic review based on the evaluation of the techniques and methods used for the sampling/monitoring (S/M) of atmospheric pollutants in rural and agricultural settings, which highlights the shortcomings in this field and the need for future studies. This work aims to review the study design applied for on-field monitoring campaigns of airborne pollutants in rural environments and discuss the possible needs and future developments in this field. The results of this literature review, based on the revision of 23 scientific papers, allowed us to determine (i) the basic characteristics related to the study design that should always be reported; (ii) the main techniques and analyses used in exposure assessment studies conducted in this type of setting; and (iii) contextual parameters and descriptors of the S/M site that should be considered to best support the results obtained from the different studies. Future studies carried out to monitor the airborne pollution in rural/agriculture areas should (i) include the use of multiparametric monitors for the contextual measurement of different atmospheric pollutants (as well as meteorological parameters) and (ii) consider the most important boundary information, to better characterize the S/M site.
Real-Time Monitoring of Fecal Nitrogen Excretion to the Environment Using Near-Infrared Reflectance Spectroscopy: A Preliminary Study in Rabbits
Authors: Fortatos Efstathios , Hadjigeorgiou Ioannis , Mountzouris Konstantinos C. , Papadomichelakis George
Published: December 2023

The excessive excretion of nitrogen (N) by farm animals can pose severe environmental risks. In this study, near-infrared reflectance (NIR) spectroscopy (NIRS) was used to explore the feasibility of developing a real-time in situ monitoring tool for fecal N excretion in rabbits. A total of 70 feed and 282 fecal samples from an in vivo digestibility experiment were used. Feed and fecal NIR spectra were employed to develop chemometric models using modified partial least squares (MPLS) for feed and feces, and artificial neural networks (ANN) for feces to predict dietary and fecal N content and fecal N digestibility. Very good accuracy was achieved in predicting feed N (R2val = 0.96; standard error of prediction, SEP = 0.15) and fecal N (R2val = 0.88; SEP = 0.44) content, whereas N digestibility models from wet fecal spectra had a relatively low precision (R2val = 0.70; SEP = 0.018) with MPLS methodology. In contrast, ANNs yielded more robust prediction models for fecal (R2val = 0.98; SEP = 0.25) N content and N digestibility (R2val = 0.91; SEP = 0.012) using wet feces. In conclusion, NIRS calibration with ANNs can be a suitable tool for monitoring the environmental load of N with high precision and accuracy.
Fish Recognition in the Underwater Environment Using an Improved ArcFace Loss for Precision Aquaculture
Authors: Liu Liang , Wu Junfeng , Zheng Tao , Zhao Haiyan , Kong Han , Qu Boyu , Yu Hong
Published: December 2023

Accurate fish individual recognition is one of the critical technologies for large-scale fishery farming when trying to achieve accurate, green farming and sustainable development. It is an essential link for aquaculture to move toward automation and intelligence. However, existing fish individual data collection methods cannot cope with the interference of light, blur, and pose in the natural underwater environment, which makes the captured fish individual images of poor quality. These low-quality images can cause significant interference with the training of recognition networks. In order to solve the above problems, this paper proposes an underwater fish individual recognition method (FishFace) that combines data quality assessment and loss weighting. First, we introduce the Gem pooing and quality evaluation module, which is based on EfficientNet. This module is an improved fish recognition network that can evaluate the quality of fish images well, and it does not need additional labels; second, we propose a new loss function, FishFace Loss, which will weigh the loss according to the quality of the image so that the model focuses more on recognizable fish images, and less on images that are difficult to recognize. Finally, we collect a dataset for fish individual recognition (WideFish), which contains and annotates 5000 images of 300 fish. The experimental results show that, compared with the state-of-the-art individual recognition methods, Rank1 accuracy is improved by 2.60% and 3.12% on the public dataset DlouFish and the proposed WideFish dataset, respectively.
Blood Transcriptome Analysis Provides Responsive Changes in Gene Expression between Ex Situ and Captive Yangtze Finless Porpoises (Neophocaena asiaeorientalis asiaeorientalis)
Authors: Cao Zhichen , Yin Denghua , Li Zhanwei , Yan Yan , Zhang Peng , Zhang Sigang , Lin Danqing , Hua Zhong , Zhang Jialu , Ying Congping , Zhang Han , Xu Pao , Dong Guixin , Liu Kai
Published: December 2023

The Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis, YFP) is an endangered species endemic to the Yangtze River in China, and it is the only freshwater whale in the genus Neophocaena. In terms of protection, three effective conservation strategies exist: in situ conservation, ex situ conservation, and artificial breeding, all of which have been implemented by the Chinese government. Of these, ex situ conservation involves the relocation of Yangtze finless porpoises to semi-natural waters with less human interference, and artificial breeding involves the relocation of Yangtze finless porpoises to a controlled environment that is more strictly managed. To compare and analyze the responsive changes in gene expression of the YFPs between the ex situ and controlled environments, we performed the RNA sequencing of blood tissues from these YFPs. A total of 1201 differentially expressed genes (DEGs) were identified, of which 423 were up-regulated in the ex situ population and 778 were up-regulated in the controlled-environment population. Gene enrichment analysis showed that 1201 DEGs between the ex situ and controlled-environment populations were generally enriched for vision-, digestion- and immune-system-related pathways. Further analysis revealed that several key immune system pathways, such as the chemokine signaling pathway and B cell receptor signal pathway, were activated in the ex situ population. In addition, the key pathways related to vision, including phototransduction and the inflammatory mediator regulation of TRP channels, as well as the pathways related to the digestive system, such as protein digestion and absorption and salivary secretion, were activated in the controlled-environment population. These results suggest that the ex situ populations may respond to complex environmental conditions in semi-natural waters by enhancing their immune function through the increased expression of immune-related genes and that the visual function and protein digestion of the YFPs were improved compared to those of the ex situ population based on the conditions of artificial feeding, such as the higher transparency of the water and regular feeding. This study provides clues for evaluating the adaptability of YFPs to different environments and is a useful reference for future ex situ conservation and artificial breeding.
The Extract of Astragalus membranaceus Inhibits Lipid Oxidation in Fish Feed and Enhances Growth Performance and Antioxidant Capacity in Jian Carp (Cyprinus carpio var. Jian)
Authors: Xu Jing , Chen Gangfu , Wu Min , Yang Qihui , Li Huatao
Published: December 2023

In this study, a linoleic and linolenic acid were incubated with petroleum ether extract, ethyl acetate extract, acetone extract (AE) and aqueous extract of Astragalus membranaceus. The phenolic content and total antioxidant capacity (T-AOC) were determined in the extracts of Astragalus membranaceus (EAms) above. Results showed that EAms decreased the levels of malonaldehyde, conjugated diene, and peroxide value levels in material above. Of all of EAms, AE showed the strongest T-AOC and inhibitory effect on the lipid oxidation. Next, fish feeds were incubated with graded levels of AE. The results showed that AE inhibited lipid oxidation in fish feed. The appropriate dosage for reducing lipid oxidation was 6.74 g AE kg−1 feeds. The effect of EAms on the lipid oxidation may be closely associated with their phenolic content. Then, juvenile Jian carp (Cyprinus carpio var. Jian, 10.2 ± 0.3 g) were fed with diets containing graded levels of AE (0.0, 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, and 7.0 g kg−1) for 60 days. Current data displayed that dietary AE increased the growth performance of fish. The optimum dosage for growth promotion was 5.15 g AE kg−1 diet. This result of AE may be ascribed to its enhancing effect on the activity of digestive and absorptive enzymes and antioxidant capacity in digestive organs of fish. Our present study indicated that EAm holds promise as a natural antioxidant for fish and their feed.
Optimizing Processing Techniques of Oolong Tea Balancing between High Retention of Catechins and Sensory Quality
Authors: Lu Xiaofeng , Lin Yanyan , Tuo Yanming , Liu Lijia , Du Xinxin , Zhu Qiufang , Hu Yunfei , Shi Yutao , Wu Liangyu , Lin Jinke
Published: December 2023

Catechins are the major flavor substances in teas, which have a variety of health effects; however, high catechin and high sensory quality are a pair of contradictions that are difficult to coordinate. To explore the processing procedure with high catechins and high sensory quality, a single-factor processing experiment was carried out over the processing production of oolong tea. Combined with orthogonal partial least square discriminant analysis (OPLS-DA), correlation analysis, and principal component analysis (PCA), the optimal production procedure for oolong tea is as follows: red light withering for 8 h, leaf rotating for 10 min with a total standing time for 8 h, drum roasting for 5 min at 290 °C, low-temperature rolling (flattening at 4 °C for 5 min, without pressure for 1 min and under pressure for 5 min), microwave drying (800 W for 7.5 min). This study demonstrates a significant increase in the retention of catechins, which contributes to the mellow and brisk tastes of oolong tea, addressing the challenge of catechin content and sensory quality. Our study provides a novel insight into the relationship between the oolong tea processing and flavor formation.
Circular Bioeconomy: Novel Processes and Materials for Food Preservation
Authors: Torrres-Giner Sergio , Chiralt Amparo , González-Martínez Chelo
Published: December 2023

Food preservation is a set of procedures and resources aimed at blocking the action of external and internal agents that may alter the original characteristics of food [...]
Pharmacokinetic Profiling of Ginsenosides, Rb1, Rd, and Rg3, in Mice with Antibiotic-Induced Gut Microbiota Alterations: Implications for Variability in the Therapeutic Efficacy of Red Ginseng Extracts
Authors: Kim Jeon-Kyung , Choi Min Sun , Park Hee-Seo , Kee Kyung Hwa , Kim Dong-Hyun , Yoo Hye Hyun
Published: December 2023

Ginsenoside Rg3 is reported to contribute to the traditionally known diverse effects of red ginseng extracts. Significant individual variations in the therapeutic efficacy of red ginseng extracts have been reported. This study aimed to investigate the effect of amoxicillin on the pharmacokinetics of ginsenosides Rb1, Rd, and Rg3 in mice following the oral administration of red ginseng extracts. We examined the α-diversity and β-diversity of gut microbiota and conducted pharmacokinetic studies to measure systemic exposure to ginsenoside Rg3. We also analyzed the microbiome abundance and microbial metabolic activity involved in the biotransformation of ginsenoside Rb1. Amoxicillin treatment reduced both the α-diversity and β-diversity of the gut microbiota and decreased systemic exposure to ginsenoside Rg3 in mice. The area under the curve (AUC) values for Rg3 in control and amoxicillin-treated groups were 247.7 ± 96.6 ng·h/mL and 139.2 ± 32.9 ng·h/mL, respectively. The microbiome abundance and microbial metabolic activity involved in the biotransformation of ginsenoside Rb1 were also altered by amoxicillin treatment. The metabolizing activity was reduced from 0.13 to 0.05 pmol/min/mg on average. Our findings indicate that amoxicillin treatment potentially reduces the gut-microbiota-mediated metabolism of ginsenoside Rg3 in mice given red ginseng extracts, altering its pharmacokinetics. Gut microbiome variations may thus influence individual ginsenoside pharmacokinetics, impacting red ginseng extract’s efficacy. Our results suggest that modulating the microbiome could enhance the efficacy of red ginseng.
Nutritional and Technological Properties of Albino Peach Palm (Bactris gasipaes) from the Amazon: Influence of Cooking and Drying
Authors: Soares Stephanie Dias , dos Santos Orquídea Vasconcelos , da Conceição Leyvison Rafael Vieira , Costi Hilton Túlio , Silva Júnior José Otávio Carrera , Nascimento Francisco das Chagas Alves do , Pena Rosinelson da Silva
Published: December 2023

This study aimed to subject the albino peach palm to cooking and drying processes and characterize the raw pulp (RP), cooked pulp (CP), raw pulp flour (RPF), and cooked pulp flour (CPF). The product’s chemical composition, bioactive compounds, and physicochemical, color, thermal, morphological, and functional–technological properties were evaluated. The proximate composition showed that carbohydrates were the main constituents of all the products (69.59–72.08 g/100 g). The cooking process decreased the lipids (10.21 to 8.63 g/100 g), dietary fiber (13.64 to 12.81 g/100 g), and total sugar content (59.18 to 49.10 g/100 g) of the CP. The colorimetric parameters indicated a significant browning of the CP and CPF, which can be attributed to the Maillard reaction and lipid oxidation. After cooking, the total phenolic compound and ascorbic acid content decreased in the pulp. The RPF and CPF displayed different thermogravimetric behaviors. The spectral patterns in the infrared region showed the characteristic bands of organic compounds that are present in the structure of starches. The scanning electron microscopy showed amyloplast and fiber bundles with starches in the RP and gelatinized starch granules in the CP and CPF. The RPF presented small and heterogeneous starch granules with isolated amyloplast. The RPF and CPF showed different granulometric patterns and technological indices. The results suggest that the pulp and flour from the pulp of albino peach palms can be exploited by the food, pharmaceutical, and biotechnological industries.
Fractional-Order Extremum Seeking Method for Maximum Torque per Ampere Control of Permanent Magnet Synchronous Motor
Authors: Song Haiying , Duan Dejie , Yan Yiying , Li Xinyao , Xie Min
Published: December 2023

Maximum torque per ampere (MTPA) control of internal permanent magnet synchronous motors (IPMSM) has become integral to high-efficiency motor drives. To minimize the influence of the traditional model-based analytical solution method on the MTPA control strategy due to the parameter variations during the motor operation, an online search MTPA method without model-based fractional-order extremum seeking control (FO-ESC) is proposed. Compared with the traditional integer-order ESC method, the Oustaloup approximation-based fractional-order calculus provides additional factors and possibilities for optimizing controller parameters to improve control performance. At the same time, the proposed approach does not require machine parameters and is thus not influenced by machine and drive nonlinearities. Simulation results show that the proposed method can ensure robust MTPA control under different loading conditions in real-time and improve the system’s dynamic response speed and steady-state accuracy.
Pricing European Options under a Fuzzy Mixed Weighted Fractional Brownian Motion Model with Jumps
Authors: Xu Feng , Yang Xiao-Jun
Published: December 2023

This study investigates the pricing formula for European options when the underlying asset follows a fuzzy mixed weighted fractional Brownian motion within a jump environment. We construct a pricing model for European options driven by fuzzy mixed weighted fractional Brownian motion with jumps. By converting the partial differential equation (PDE) into a Cauchy problem, we derive explicit solutions for both European call options and European put options. The figures and tables demonstrating the effectiveness of the results highlight the suitability of the fuzzy mixed weighted fractional Brownian motion with jump model for option pricing.
Generalized Hyperbolic Discounting in Security Games of Timing
Authors: Merlevede Jonathan , Johnson Benjamin , Grossklags Jens , Holvoet Tom
Published: December 2023

In recent years, several high-profile incidents have spurred research into games of timing. A framework emanating from the FlipIt model features two covert agents competing to control a single contested resource. In its basic form, the resource exists forever while generating value at a constant rate. As this research area evolves, attempts to introduce more economically realistic models have led to the application of various forms of economic discounting to the contested resource. This paper investigates the application of a two-parameter economic discounting method, called generalized hyperbolic discounting, and characterizes the game’s Nash equilibrium conditions. We prove that for agents discounting such that accumulated value generated by the resource diverges, equilibrium conditions are identical to those of non-discounting agents. The methodology presented in this paper generalizes the findings of several other studies and may be of independent interest when applying economic discounting to other models.
Colorectal Cancer: 35 Cases in Asbestos-Exposed Workers
Authors: Porzio Antonietta , Feola Alessandro , Parisi Giuseppe , Lauro Angelo , Campobasso Carlo Pietro
Published: December 2023

Background: Asbestos is considered one of the major global work-related carcinogens. Some studies suggest a potential causal relationship between asbestos exposure and colorectal cancer (CRC). However, the role of asbestos in CRC carcinogenesis is still controversial. Methods: 35 claims of occupational CRC among asbestos-exposed workers were reviewed. All claims were rejected by the Italian National Institute for Insurance against Accidents (INAIL) due to the “lack of scientific evidence in the causality” between asbestos exposure and CRC; causality was finally assessed in civil trials. All cases were categorized by age, gender, industry type, task, exposure and latency periods, anatomical location, and histopathological characteristics of CRC and concomitant respiratory diseases. Results: Most workers were males aged 60 years or more and employed in occupational activities with extensive use of asbestos for over 20 years. In 31 out of 35 cases, CRC was diagnosed over 39 years after employment. Right-sided colic adenocarcinoma was diagnosed in nine cases; rectum was involved in eight cases. Respiratory comorbidities were observed in 22 workers. Conclusions: Our study provides some interesting points in the assessment of the causal relationship between asbestos exposure and CRC.
Podiatric Skin and Nail Involvement and Biomechanical Pathology in Renal Transplant Recipients: Assessment of the Foot as a Contributing Factor to Their Health
Authors: González-Martín Cristina , Balboa-Barreiro Vanesa , Garcia-Rodriguez Mª Teresa , Veiga-Seijo Raquel , Seoane-Pillado Teresa , Couceiro-Sanchez Estefanía
Published: December 2023

Although several studies show the prevalence of podiatric conditions in people with end-stage renal disease or renal replacement therapy with hemodialysis, there is little scientific literature on this when subjects are undergoing kidney transplantation. The aim of this study is to determine the prevalence of podiatric skin and nail pathology in renal transplant recipients. A descriptive, observational, prevalence study was conducted at the Nephrology Department of the University Hospital of A Coruña. A total of 371 subjects were studied. The variables studied were sociodemographic (age, sex), anthropometric (Body Mass Index), comorbidity (Charlson Comorbidity Index), and podological (skin and nail alterations). A high presence of skin (83.1%) and nail pathology (85.4%) was observed, with hyperkeratosis (68.8%), onychogryphosis (39.4%), and onychocryptosis (36.9%) being the most predominant alterations. Although it was not significant, patients with a higher risk of presenting podiatric pathology were of female sex and had a high BMI, and both age and the Charlson comorbidity index were significantly associated with this risk. There was an increased risk of both skin and nail pathology at older age and in the presence of diabetes mellitus.
Surviving the Storm: The Impact of COVID-19 on Cervical Cancer Screening in Low- and Middle-Income Countries
Authors: Vahabi Mandana , Shahil-Feroz Anam , Lofters Aisha , Wong Josephine Pui-Hing , Prakash Vijayshree , Pimple Sharmila , Anand Kavita , Mishra Gauravi
Published: December 2023

According to the Center for Disease Control and Prevention’s National Breast and Cervical Cancer Early Detection Program, the cervical cancer screening rate dropped by 84% soon after the declaration of the COVID-19 pandemic. The challenges facing cervical cancer screening were largely attributed to the required in-person nature of the screening process and the measures implemented to control the spread of the virus. While the impact of the COVID-19 pandemic on cancer screening is well-documented in high-income countries, less is known about the low- and middle-income countries that bear 90% of the global burden of cervical cancer deaths. In this paper, we aim to offer a comprehensive view of the impact of COVID-19 on cervical cancer screening in LMICs. Using our study, “Prevention of Cervical Cancer in India through Self-Sampling” (PCCIS), as a case example, we present the challenges COVID-19 has exerted on patients, healthcare practitioners, and health systems, as well as potential opportunities to mitigate these challenges.
Beyond Hypoglossal Hype: Social Media Perspectives on the Inspire Upper Airway Stimulation System
Authors: Rossi Nicholas A. , Vories Bridget A. , Razmi Samuel E. , Momin Nishat A. , Burgess Zachary S. , Pine Harold S. , Shabani Sepehr , Sultana Rizwana , McKinnon Brian J.
Published: December 2023

In the landscape of sleep surgery, the Inspire® Upper Airway Stimulation (UAS) device has gained prominence as an increasingly popular treatment option for obstructive sleep apnea, prompting significant discourse across social media platforms. This study explores the social media narrative of the UAS device, particularly the nature of multimedia content, author demographics, and audience engagement on Instagram, Facebook, and TikTok. Our analysis encompassed 423 public posts, revealing images (67.4%) and videos (28.1%) as the dominant content types, with over a third of posts authored by physicians. A notable 40% of posts were advertisements, whereas patient experiences comprised 34.5%. TikTok, although presenting a smaller sample size, showed a substantially higher engagement rate, with posts averaging 152.9 likes, compared with Instagram and Facebook at 32.7 and 41.2 likes, respectively. The findings underscore the need for otolaryngologists and healthcare professionals to provide clear, evidence-based information on digital platforms. Given social media’s expanding role in healthcare, medical professionals must foster digital literacy and safeguard the accuracy of health information online. In this study, we concluded that maintaining an evidence-based, transparent digital dialogue for medical innovations such as the UAS device necessitates collaborative efforts among physicians, health institutions, and technology companies.
The Effectiveness of Pilates Training Interventions on Older Adults’ Balance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Sampaio Tatiana , Encarnação Samuel , Santos Olga , Narciso Diogo , Oliveira João P. , Teixeira José E. , Forte Pedro , Morais Jorge E. , Vasques Catarina , Monteiro António Miguel
Published: December 2023

Background and Objectives: Pilates training intervention programs have gained attention as a potential approach to enhancing balance in older adults, thereby reducing the risk of falls. In light of these considerations, this systematic review and meta-analysis aimed to critically evaluate the existing evidence and determine the effect of Pilates training intervention programs on older adults’ balance. Materials and Methods: The literature was searched through the PubMed, Web of Science, and Scopus databases from inception until July 2023. The primary keywords used for the literature search included “elderly” or “older adults” and “pilates training” and “balance”. Results: The systematic review through qualitative analysis showed robust evidence about the efficacy of Pilates intervention programs in improving older adults’ balance. The pooled meta-analysis of static and dynamic balance showed that eight (53%) out of a total fifteen analyzed interventions presented a significant effect of Pilates in improving the participants’ balance, without between-study heterogeneity. In addition, the meta-analysis regarding dynamic balance showed that six (67%) out of nine analyzed interventions presented a significant effect of Pilates in improving the participants’ balance, without heterogeneity between studies. Similarly, the meta-analysis regarding static balance showed that four (50%) out of eight analyzed studies presented significant effects on the older adults’ balance, where moderate between-study heterogeneity was found. Sensitivity analysis showed that three studies reduced the between-study heterogeneity (19, 17.6, and 17%), regressing from moderate to low heterogeneity, p < 0.05. Conclusions: This systematic review and meta-analysis underscores the potential of Pilates training as a valuable intervention to enhance balance in the elderly population.
Evaluation of Radon Action Plans: Searching for a Systematic and Standardised Method
Authors: Martell Meritxell , Perko Tanja , Navrátilová Rovenská Kateřina , Fojtíková Ivana , Geysmans Robbe
Published: December 2023

Radon, a carcinogenic radioactive gas, is a leading cause of lung cancer according to the World Health Organization. European Member States are required to develop and implement National Radon Action Plans (RAPs) to address its dangerous health effects. However, assessing the effectiveness of these RAPs presents challenges for authorities. This study aims to explore the possibility of a systematic and standardised assessment method to evaluate the effectiveness of RAP strategies and its implementation. The method involved analysing the strategies of 27 EU Member States and the UK, conducting legal document analysis and group interviews with responsible authorities. Additionally, four regional workshops and one final European workshop were held. The research took place from March 2021 to May 2023. Findings indicate that evaluating RAP effectiveness is challenging due to limited existing common criteria or indicators. To address this, the study proposes guiding questions for each element required by the EU Directive, as well as additional questions related to education and training. This contribution benefits RAP owners and European regulatory authorities, supporting the development of effectiveness indicators for RAPs. By improving assessment methods, we can enhance the effectiveness of strategies in mitigating the risks associated with radon exposure.
Study of the Relationship between Sensory Processing Sensitivity and Burnout Syndrome among Speech and Language Therapists
Authors: Bordarie Jimmy , Mourtialon Caroline
Published: December 2023

Background: Burnout syndrome can arise due to either situational factors such as working conditions, or dispositional factors such as certain temperaments, like a high sensory processing sensitivity. We aim to address the relative absence of studies on speech-language therapists and seek to determine the role of high sensitivity for these healthcare workers in relation to burnout syndrome. Method: The sample consisted of 602 female speech-language pathologists who anonymously completed a questionnaire measuring burnout (ProQOL 5th edition) and sensory processing sensitivity (HSPS-FR). Results: The results revealed that 77.41% of the participants reported moderate or high burnout scores. Furthermore, the analyses revealed that highly sensitive participants are more vulnerable to burnout than others. Conclusion: This study highlights the negative impact of high sensory processing sensitivity on burnout. However, according to the kind of sensitivity, we discuss the way in which highly sensitive caregivers can master this sensitivity in order to use it as a strength in their professions and to spare themselves from suffering deleterious effects, such as compassion fatigue and/or burnout.