bluuebunny/crossref_metadata_2025 huggingface dataset:
Fabrication of Co-Based Cladding Layer by Microbeam Plasma and Its Corrosion Mechanism to Molten Salt
Authors: Sun Kaiqi , Zhang Yufeng , Wang Yingfan , Ye Fuxing
Published: August 2024

Corrosion of the molten salts Na2SO4 and NaCl has become one of the major factors in the failure of steel components in boilers and engines. In this study, CoNiCrAlY cobalt-based cladding layers with different NiCr-Cr3C2 ratios were prepared by microbeam plasma cladding technology. The influence of the NiCr-Cr3C2 content on the microstructure, mechanical properties, and molten salt corrosion resistance of CoNiCrAlY was investigated. The CoNiCrAlY with a 25 wt.% NiCr-Cr3C2 (NC25) cladding layer possessed the highest microhardness (348.2 HV0.3) and the smallest coefficient of friction (0.4751), exhibiting great overall mechanical properties. The generation of protective oxides Cr2O3, Al2O3, and spinel phase (Ni,Co)Cr2O4 is promoted by the addition of 25 wt.% NiCr-Cr3C2, which significantly reduces the corrosion of the cladding layer, and this effect is much more obvious at 950 °C than that at 750 °C. Furthermore, its corrosion mechanism was clarified. From the findings emerge a viable solution for the design and development of new high-temperature corrosion-resistant coatings.
Mercury Ion Selective Adsorption from Aqueous Solution Using Amino-Functionalized Magnetic Fe2O3/SiO2 Nanocomposite
Authors: Youssif Mahmoud M. , El-Attar Heba G. , Małecki Stanisław , Włoch Grzegorz , Czapkiewicz Maciej , Kornaus Kamil , Wojnicki Marek
Published: August 2024

This study focuses on the development of new amino-functionalized magnetic Fe2O3/SiO2 nanocomposites with varying silicate shell ratios (1:0.5, 1:1, and 1:2) for the efficient elimination of Hg2+ ions found in solutions. The Fe2O3/SiO2–NH2 adsorbents were characterized for their structural, surface, and magnetic properties using various techniques, including Fourier transform infrared spectrum (FT-IR), powder X-ray diffraction (XRD), scanning electron microscopy (SEM), Braunauer–Emmett–Teller (BET), thermogravimetric analysis (TGA), zeta-potential, and particle size measurement. We investigated the adsorption circumstances, such as pH, dosage of the adsorbent, and duration of adsorption. The pH value that yielded the best results was determined to be 5.0. The Fe2O3/SiO2–NH2 adsorbent with a silicate ratio of (1:2) exhibited the largest amount of adsorption capacity of 152.03 mg g−1. This can be attributed to its significantly large specific surface area of 100.1 m2 g−1, which surpasses that of other adsorbents. The adsorbent with amino functionalization demonstrated a strong affinity for Hg2+ ions due to the chemical interactions between the metal ions and the amino groups on the surface. The analysis of adsorption kinetics demonstrated that the adsorption outcomes adhere to the pseudo-second-order kinetic model. The study of adsorption isotherms revealed that the adsorption followed the Langmuir model, indicating that the adsorption of Hg2+ ions with the adsorbent occurred as a monomolecular layer adsorption process. Furthermore, the thermodynamic analyses revealed that the adsorption of Hg2+ ions using the adsorbent was characterized by a spontaneous and endothermic process. Additionally, the adsorbent has the ability to selectively extract mercury ions from a complex mixture of ions. The Fe2O3/SiO2–NH2 nanocomposite, which is loaded with metal, can be easily recovered from a water solution due to its magnetic properties. Moreover, it can be regenerated effortlessly through acid treatment. This study highlights the potential use of amino-functionalized Fe2O3/SiO2 magnetic nanoparticles as a highly efficient, reusable adsorbent for the removal of mercury ions from contaminated wastewater.
A Comprehensive Review of Stimuli-Responsive Smart Polymer Materials—Recent Advances and Future Perspectives
Authors: Balcerak-Woźniak Alicja , Dzwonkowska-Zarzycka Monika , Kabatc-Borcz Janina
Published: August 2024

Today, smart materials are commonly used in various fields of science and technology, such as medicine, electronics, soft robotics, the chemical industry, the automotive field, and many others. Smart polymeric materials hold good promise for the future due to their endless possibilities. This group of advanced materials can be sensitive to changes or the presence of various chemical, physical, and biological stimuli, e.g., light, temperature, pH, magnetic/electric field, pressure, microorganisms, bacteria, viruses, toxic substances, and many others. This review concerns the newest achievements in the area of smart polymeric materials. The recent advances in the designing of stimuli-responsive polymers are described in this paper.
Energy Absorption Behavior of Carbon-Fiber-Reinforced Plastic Honeycombs under Low-Velocity Impact Considering Their Ply Characteristics
Authors: Liu Zheng , Zou Kai , Zhang Zhendong
Published: August 2024

Honeycomb structures made of carbon-fiber-reinforced plastic (CFRP) are increasingly used in the aerospace field due to their excellent energy absorption capability. Attention has been paid to CFRP structures in order to accurately simulate their progressive failure behavior and discuss their ply designability. In this study, the preparation process of a CFRP corrugated sheet (half of the honeycomb structure) and a CFRP honeycomb structure was illustrated. The developed finite element method was verified by a quasi-static test, which was then used to predict the low-velocity impact (LVI) behavior of the CFRP honeycomb, and ultimately, the influence of the ply angle and number on energy absorption was discussed. The results show that the developed finite element method (including the user-defined material subroutine VUMAT) can reproduce the progressive failure behavior of the CFRP corrugated sheet under quasi-static compression and also estimate the LVI behavior. The angle and number of plies of the honeycomb structure have an obvious influence on their energy absorption under LVI. Among them, energy absorption increases with the ply number, but the specific energy absorption is basically constant. The velocity drop ratios for the five different ply angles are 79.12%, 68.49%, 66.88%, 66.86%, and 60.02%, respectively. Therefore, the honeycomb structure with [0/90]s ply angle had the best energy absorption effect. The model proposed in this paper has the potential to significantly reduce experimental expenses, while the research findings can provide valuable technical support for design optimization in aerospace vehicle structures.
Analysis of Rheological Properties and Regeneration Mechanism of Recycled Styrene–Butadiene–Styrene Block Copolymer (SBS) Modified Asphalt Binder Using Different Rejuvenators
Authors: Ma Hongmei , Guo Fucheng , Han Jihong , Zhi Pengfei
Published: August 2024

The regeneration performance of an aged styrene–butadiene–styrene block copolymer (SBS) will be significantly influenced by different rejuvenators. The objective of this study was to comparatively investigate the regeneration effect of different SBS-modified asphalt regenerators on aged SBS-modified asphalt. Four types of different regenerant formulations were selected. The optimal rejuvenator content was determined firstly using conventional performance tests. The rheological properties of the aged SBS-modified asphalt binder were evaluated by multiple stress creep recovery (MSCR) experiments. Subsequently, the regeneration mechanism of the SBS-modified asphalt binder was investigated using thin-layer chromatography–flame ionization detection (TLC-FID) and Fourier transform infrared spectroscopy (FTIR). The results showed that the rejuvenator had a certain recovery effect on the penetration, softening point, and ductility of the SBS-modified asphalt binder after aging. The SBS-modified rejuvenating agent was the most favorable among the four types of rejuvenators, where a rejuvenator dosage of 12% showed the optimal rejuvenation effect. The addition of regenerators could appropriately improve the elastic deformation capacity of the aged asphalt binder. The epoxy soybean oil in the regenerant reacted with the aging SBS-modified asphalt binder, supplementing the lost oil in the aged SBS-modified asphalt binder, dispersing the excessive accumulation of asphaltene, and making the residual SBS swell again. The viscoelastic properties of the aging asphalt binder were improved by adjusting the content of components and functional groups to achieve the purpose of regeneration.
PCDA/ZnO Organic–Inorganic Hybrid Photoanode for Efficient Photoelectrochemical Solar Water Splitting
Authors: Akhmetzhanov Nursalim , Zhang Mao , Lee Dongyun , Hwang Yoon-Hwae
Published: August 2024

In this study, we developed well-aligned ZnO nanoflowers coated with poly-10,12-pentacosadiyonic acid (p-PCDA@ZnO) and modified with Pt nanoparticle (Pt/p-PCDA@ZnO) hybrid photoanodes for highly efficient photoelectrochemical (PEC) water splitting. The scanning electron microscope (SEM) image shows that thin films of the p-PCDA layer were well coated on the ZnO nanoflowers and that Pt nanoparticles were on it. The photoelectrochemical characterizations were made under simulated solar irradiation AM 1.5. The current density of the p-PCDA@ZnO and the Pt/p- PCDA@ZnO was 0.227 mA/cm2 and 0.305 mA/cm2, respectively, and these values were three times and four times higher compared to the 0.071 mA/cm2 of the bare ZnO nanoflowers. The UV–visible spectrum showed that the absorbance of coated p-PCDA films was extended in visible light region, which agrees with the enhanced PEC data for p-PCDA@ZnO. Also, adding Pt nanoparticles on top of the films as co-catalysts enhanced the PEC performance of Pt/p-PCDA@ZnO further. This indicates that Pt/p- PCDA@ZnO has a great potential to be implemented in solar water splitting.
Microstructure, Mechanical, and Tribological Properties of Nb-Doped TiAl Alloys Fabricated via Laser Metal Deposition
Authors: Huang Kai , Xu Feng , Liu Xinyan , Liu Shiqiu , Wang Qingge , Baker Ian , Song Min , Wu Hong
Published: August 2024

TiAl alloys possess excellent properties, such as low density, high specific strength, high elastic modulus, and high-temperature creep resistance, which allows their use to replace Ni-based superalloys in some high-temperature applications. In this work, the traditional TiAl alloy Ti-48Al-2Nb-2Cr (Ti4822) was alloyed with additional Nb and fabricated using laser metal deposition (LMD), and the impacts of this additional Nb on the microstructure and mechanical and tribological properties of the as-fabricated alloys were investigated. The resulting alloys mainly consisted of the γ phase, trace β0 and α2 phases. Nb was well distributed throughout the alloys, while Cr segregation resulted in the residual β0 phase. Increasing the amount of Nb content increased the amount of the γ phase and reduced the amount of the β0 phase. The alloy Ti4822-2Nb exhibited a room-temperature (RT) fracture strength under a tensile of 568 ± 7.8 MPa, which was nearly 100 MPa higher than that of the Ti4822-1Nb alloy. A further increase in Nb to an additional 4 at.% Nb had little effect on the fracture strength. Both the friction coefficient and the wear rate increased with the increasing Nb content. The wear mechanisms for all samples were abrasive wear with local plastic deformation and oxidative wear, resulting in the formation of metal oxide particles.
Investigation on Cement-Stabilized Base with Recycled Aggregate and Desert Sand
Authors: Liu Fengchao , Qin Yongjun , Yang Yiheng
Published: August 2024

This paper mainly explores the feasibility of using desert sand (DS) and recycled aggregate in cement-stabilized bases. Recycled coarse aggregate (RCA) and DS serve as the substitutes of natural coarse and fine aggregates, respectively, in cement-stabilized bases. A four-factor and four-level orthogonal test is designed to analyze the unconfined compressive strength, splitting tensile strength, and compressive resilient modulus. Furthermore, this paper investigates the effects of cement content, fly ash (FA) replacement rate, RCA replacement rate, and DS replacement rate on the road performance of cement-stabilized bases composed of RCA and DS. The test results reveal that the performance of cement-stabilized bases with partial RCA instead of natural coarse aggregate (NCA) and partial DS instead of natural fine aggregate satisfies the road use. The correlation and microscopic analyses of the test results imply the feasibility of applying DS and recycled aggregate to cement-stabilized bases. This paper calculates and evaluates the life cycle of carbon emissions of desert sand and recycled coarse aggregate cement-stabilized macadam (DRCSM) and finds that both DS and RCA can reduce the carbon emissions of CSM, which has a positive effect on improving the environment and solving the climate crisis. It is hoped that this paper can offer a solid theoretical foundation for promoting the application of DS and recycled aggregate in road engineering.
Detecting Anomalies in Hydraulically Adjusted Servomotors Based on a Multi-Scale One-Dimensional Residual Neural Network and GA-SVDD
Authors: Yang Xukang , Jiang Anqi , Jiang Wanlu , Zhao Yonghui , Tang Enyu , Qi Zhiqian
Published: August 2024

A high-pressure hydraulically adjusted servomotor is an electromechanical–hydraulic integrated system centered on a servo valve that plays a crucial role in ensuring the safe and stable operation of steam turbines. To address the issues of difficult fault diagnoses and the low maintenance efficiency of adjusted hydraulic servomotors, this study proposes a model for detecting abnormalities of hydraulically adjusted servomotors. This model uses a multi-scale one-dimensional residual neural network (M1D_ResNet) for feature extraction and a genetic algorithm (GA)-optimized support vector data description (SVDD). Firstly, the multi-scale features of the vibration signals of the hydraulically adjusted servomotor were extracted and fused using one-dimensional convolutional blocks with three different scales to construct a multi-scale one-dimensional residual neural network binary classification model capable of recognizing normal and abnormal states. Then, this model was used as a feature extractor to create a feature set of normal data. Finally, an abnormal detection model for the hydraulically adjusted servomotor was constructed by optimizing the support vector data domain based on this feature set using a genetic algorithm. The proposed method was experimentally validated on a hydraulically adjusted servomotor dataset. The results showed that, compared with the traditional single-scale one-dimensional residual neural network, the multi-scale feature vectors fused by the multi-scale one-dimensional convolutional neural network contained richer state-sensitive information, effectively improving the performance of detecting abnormalities in the hydraulically adjusted servomotor.
Optimizing Two-Dimensional Irregular Pattern Packing with Advanced Overlap Optimization Techniques
Authors: Meng Longhui , Ding Liang , Khan Aqib Mashood , Mushtaq Ray Tahir , Alkahtani Mohammed
Published: August 2024

This research introduces the Iterative Overlap Optimization Placement (IOOP) method, a novel approach designed to enhance the efficiency of irregular pattern packing by dynamically optimizing overlap ratios and pattern placements. Utilizing a modified genetic algorithm, IOOP addresses the complexities of arranging irregular patterns in a given space, focusing on improving spatial and material efficiency. This study demonstrates the method’s superiority over the traditional Size-First Non-Iterative Overlap Optimization Placement technique through comparative analysis, highlighting significant improvements in spatial utilization, flexibility, and material conservation. The effectiveness of IOOP is further validated by its robustness in handling diverse pattern groups and its adaptability in adjusting pattern placements iteratively. This research not only showcases the potential of IOOP in manufacturing and design processes requiring precise spatial planning but also opens avenues for its application across various industries, underscoring the need for further exploration into advanced technological integrations for tackling complex spatial optimization challenges.
Existence of Solutions for a Viscoelastic Plate Equation with Variable Exponents and a General Source Term
Authors: Bouizem Youcef , Alharbi Asma , Boulaaras Salah
Published: August 2024

The subject of this study is a nonlinear viscoelastic plate equation with variable exponents and a general source term. Through the application of the Faedo–Galerkin approximation method and a fixed point theorem under appropriate assumptions, we proved the existence of weak solutions.
Multi-Objective Optimized GPSR Intelligent Routing Protocol for UAV Clusters
Authors: Chen Hao , Luo Fan , Zhou Jianguo , Dong Yanming
Published: August 2024

Unmanned aerial vehicle (UAV) clusters offer significant potential in civil, military, and commercial fields due to their flexibility and cooperative capabilities. However, characteristics such as dynamic topology and limited energy storage bring challenges to the design of routing protocols for UAV networks. This study leverages the Deep Double Q-Learning Network (DDQN) algorithm to optimize the traditional Greedy Perimeter Stateless Routing (GPSR) protocol, resulting in a multi-objective optimized GPSR routing protocol (DDQN-MTGPSR). By constructing a multi-objective routing optimization model through cross-layer data fusion, the proposed approach aims to enhance UAV network communication performance comprehensively. In addition, this study develops the above DDQN-MTGPSR intelligent routing algorithm based on the NS-3 platform and uses an artificial intelligence framework. In order to verify the effectiveness of the DDQN-MTGPSR algorithm, it is simulated and compared with the traditional ad hoc routing protocols, and the experimental results show that compared with the GPSR protocol, the DDQN-MTGPSR has achieved significant optimization in the key metrics such as the average end-to-end delay, packet delivery rate, node average residual energy variance and percentage of node average residual energy. In high dynamic scenarios, the above indicators were optimized by 20.05%, 12.72%, 0.47%, and 50.15%, respectively, while optimizing 36.31%, 26.26%, 8.709%, and 69.3% in large-scale scenarios, respectively.
Quantum Attacks on MIBS Block Cipher Based on Bernstein–Vazirani Algorithm
Authors: Xie Huiqin , Zhao Zhangmei , Wang Ke , Li Yanjun , Xin Hongcai
Published: August 2024

Because of the substantial progress in quantum computing technology, the safety of traditional cryptologic schemes is facing serious challenges. In this study, we explore the quantum safety of the lightweight cipher MIBS and propose quantum key-recovery attacks on the MIBS cipher by utilizing Grover’s algorithm and Bernstein–Vazirani algorithm. We first construct linear-structure functions based on the 5-round MIBS cipher according to the characteristics of the linear transformations, and then we obtain a quantum distinguisher of the 5-round MIBS cipher by applying Bernstein–Vazirani algorithm to the constructed functions. Finally, utilizing this distinguisher and Grover’s algorithm, we realize a 7-round key-recovery attack on the MIBS cipher, and then we expand the attack to more rounds of MIBS based on a similar idea. The quantum attack on the 7-round MIBS requires 156 qubits and has a time complexity of 210.5. An 8-round attack requires 179 qubits and has a time complexity of 222. Compared with existing quantum attacks, our attacks have better time complexity when attacking the same number of rounds.
On Spatial Systems of Bars Spherically Jointed at Their Ends and Having One Common End
Authors: Răcășan Valentin , Stănescu Nicolae-Doru
Published: August 2024

In this paper we consider a system of linear bars, spherically jointed at their ends. For each bar one end is linked to the origin. We discuss the equations from which one obtains the deviation of the origin, and some possible optimizations concerning the minimum displacement of the origin and the minimum force in one bar, which are the main goals of the paper. The optimization is performed considering that for two bars one end is unknown; that is, the angles between the bars and the axes are unknown. It is proved that it is difficult to obtain an analytical solution in the general case, and the problem can be discussed only by numerical methods. A numerical case is also studied and some comments concerning the results are given.
Dynamics of Activation and Regulation of the Immune Response to Attack by Viral Pathogens Using Mathematical Modeling
Authors: Cuesta-Herrera Ledyz , Pastenes Luis , Arencibia Ariel D. , Córdova-Lepe Fernando , Montoya Cristhian
Published: August 2024

In this paper, a mathematical model is developed to simulate the activation of regulatory T lymphocytes dynamics. The model considers the adaptive immune response and consists of epithelial cells, infected cells, free virus particles, helper and cytotoxic T lymphocytes, B lymphocytes, and regulatory T lymphocytes. A mathematical analysis was carried out to discuss the conditions of existence and stability of equilibrium solutions in terms of the basic reproductive number. In addition, the definitions and properties necessary to preserve the positivity and stability of the model are shown. The precision of these mathematical models can be affected by numerous sources of uncertainty, partly due to the balance between the complexity of the model and its predictive capacity to depict the biological process accurately. Nevertheless, these models can provide remarkably perspectives on the dynamics of infection and assist in identification specific immunological traits that improve our comprehension of immune mechanisms. The theoretical results are validated by numerical simulations using data reported in the literature. The construction, analysis, and simulation of the developed models demonstrate that the increased induced regulatory T lymphocytes effectively suppress the inflammatory response in contrast to similar cells at lower contents, playing a key role in maintaining self-tolerance and immune homeostasis.
Marine Bacteriocins: An Evolutionary Gold Mine to Payoff Antibiotic Resistance
Authors: Baindara Piyush , Dinata Roy , Mandal Santi M.
Published: August 2024

The rapid evolution of drug resistance is one of the greatest health issues of the 21st century. There is an alarming situation to find new therapeutic strategies or candidate drugs to tackle ongoing multi-drug resistance development. The marine environment is one of the prime natural ecosystems on Earth, the majority of which is still unexplored, especially when it comes to the microbes. A wide variety of bioactive compounds have been obtained from a varied range of marine organisms; however, marine bacteria-produced bacteriocins are still undermined. Owing to the distinct environmental stresses that marine bacterial communities encounter, their bioactive compounds frequently undergo distinct adaptations that confer on them a variety of shapes and functions, setting them apart from their terrestrial counterparts. Bacterially produced ribosomally synthesized and posttranslationally modified peptides (RiPPs), known as bacteriocins, are one of the special interests to be considered as an alternative to conventional antibiotics because of their variety in structure and diverse potential biological activities. Additionally, the gut microbiome of marine creatures are a largely unexplored source of new bacteriocins with promising activities. There is a huge possibility of novel bacteriocins from marine bacterial communities that might come out as efficient candidates to fight against antibiotic resistance, especially in light of the growing pressure from antibiotic-resistant diseases and industrial desire for innovative treatments. The present review summarizes known and fully characterized marine bacteriocins, their evolutionary aspects, challenges, and the huge possibilities of unexplored novel bacteriocins from marine bacterial communities present in diverse marine ecosystems.
Sulfated Aeruginosins from Lake Kinneret: Microcystis Bloom, Isolation, Structure Elucidation, and Biological Activity
Authors: Weisthal Algor Shira , Sukenik Assaf , Carmeli Shmuel
Published: August 2024

Aeruginosins are common metabolites of cyanobacteria. In the course of re-isolation of the known aeruginosins KT608A and KT608B for bioassay studies, we isolated three new sulfated aeruginosins, named aeruginosins KT688 (1), KT718 (2), and KT575 (3), from the extract of a Microcystis cell mass collected during the 2016 spring bloom event in Lake Kinneret, Israel. The structures of the new compounds were established on the basis of analyses of the 1D and 2D NMR, as well as HRESIMS data. Marfey’s method, coupled with HR ESI LCMS and chiral HPLC, was used to establish the absolute configuration of the amino acid and hydroxyphenyl lactic acid residues, respectively. Compounds 1–3 were tested for inhibition of the serine protease trypsin, and compounds 1 and 2 were found to exhibit IC50 values of 2.38 and 1.43 µM, respectively.
Disease Activity, Inflammation Markers, and Quality of Life Are Associated with Muscle Strength in Croatian Rheumatoid Arthritis Patients—A National-Based Study
Authors: Radić Mislav , Vlak Ivan , Vučković Marijana , Rendulić Slivar Senka , Kadojić Mira , Stamenković Doris , Bobek Dubravka , Radić Josipa , Gelemanović Andrea , Belančić Andrej , Bešić Erim , Vlak Tonko
Published: August 2024

Background and Objectives: Rheumatoid arthritis (RA) patients experience sarcopenia and decreased muscle mass and handgrip strength, leading to decreased quality of life and disability. The prevalence of RA varies across regions. This study aimed to evaluate the factors associated with RA in Croatian regional centres and explore correlations between clinical parameters and muscle strength. Materials and Methods: Included in this study were 267 stable RA patients from four Croatian clinical centres. The patients’ mean age was 60.4 ± 12.0 years, with 12.7% of them being male. For each study participant, information was gathered on their anthropometric characteristics, clinical and laboratory indicators, quality of life, disease activity, and sociodemographics. Results: The main results showed that in the female RA participants, the significant positive predictors are weight, height, exercise, VAS, and haemoglobin level. The negative predictors are the use of conventional synthetic disease-modifying anti-rheumatic drugs, the use of biological disease-modifying anti-rheumatic drugs, the number of tender joints, the number of swollen joints, the estimated sedimentation rate, the C-reactive protein, the disease activity score, the parameters of the EQ5D, and being prescribed with three or more medications. In the male RA participants, significant predictors of muscle strength are only weight, height, and anxiety/depression difficulties, according to the EQ5D. Conclusions: This study showed correlations between muscle strength and the parameters of disease activity, inflammation parameters, health-related quality of life, therapy, and exercise in the female RA participants in Croatia.
Anatomical Variations of the Jugular Bulb: A Critical and Comprehensive Review
Authors: Tudose Răzvan Costin , Rusu Mugurel Constantin , Triantafyllou George , Piagkou Maria , Toader Corneliu , Rădoi Petrinel Mugurel
Published: August 2024

Background and Objectives: The jugular bulb (JB) is the uppermost part of the internal jugular vein receiving the sigmoid sinus. The aim of the present research is to aid the comprehension of the JB, its abnormalities, and surrounding structures for improving both academic and surgical awareness. Materials and Methods: Various studies on this topic were critically reviewed. Cone-beam CT scans and CT and MR angiograms were used to demonstrate each type of the discussed variations. Results: Variations in the JB anatomy were thoroughly documented: high JB, dehiscent JB, hypoplasia and hyperplasia, and diverticula of the JB, as they have significant clinical implications, particularly in the context of otological and neuro-otological surgery, skull base pathology, and diagnostic imaging. Definitions and critical arguments were also specified to clarify existing literature. Additionally, we present a case report illustrating a high and dehiscent JB, an anatomical variation of clinical interest due to its potential for misdiagnosis as a glomus tumor. Another case describes a dehiscent JB with a hypotympanic air cell protruding into it, further highlighting the variability of this condition. Conclusions: It is necessary to proceed with caution when observing abnormal morphological characteristics of the JB. Preoperative assessment of each case is essential for optimal outcomes.
Neurological Side Effects of TNF-α Inhibitors Revisited: A Review of Case Reports
Authors: Gogulescu Armand , Blidisel Alexandru , Soica Codruta , Mioc Alexandra , Voicu Adrian , Jojic Alina , Voicu Mirela , Banciu Christian
Published: August 2024

Over the past two decades, the use of tumor necrosis factor alpha (TNF-α) inhibitors has significantly improved the treatment of patients with immune-mediated inflammatory diseases. Firstly, introduced for rheumatoid arthritis, these inhibitors are currently approved and used for a variety of conditions, including ankylosing spondylitis, Crohn’s disease, juvenile idiopathic arthritis, psoriasis, psoriatic arthritis, ulcerative colitis, and chronic uveitis. Despite their immense therapeutic efficacy, TNF-α inhibitors have been associated with neurological adverse effects that bring new clinical challenges. The present review collects data from multiple studies to evaluate the incidence and the relationship between TNF-α inhibitors and neurological side effects and to explore the potential underlying mechanisms of this association. Moreover, it highlights the importance of patient selection, particularly in the case of individuals with a history of demyelinating diseases, raises awareness for clinicians, and calls for ongoing research that will improve TNF-α targeting strategies and offer safer and more effective therapeutic options.
An Overview of Pre-Analytical Factors Impacting Metabolomics Analyses of Blood Samples
Authors: Thachil Amy , Wang Li , Mandal Rupasri , Wishart David , Blydt-Hansen Tom
Published: August 2024

Discrepant sample processing remains a significant challenge within blood metabolomics research, introducing non-biological variation into the measured metabolome and biasing downstream results. Inconsistency during the pre-analytical phase can influence experimental processes, producing metabolome measurements that are non-representative of in vivo composition. To minimize variation, there is a need to create and adhere to standardized pre-analytical protocols for blood samples intended for use in metabolomics analyses. This will allow for reliable and reproducible findings within blood metabolomics research. In this review article, we provide an overview of the existing literature pertaining to pre-analytical factors that influence blood metabolite measurements. Pre-analytical factors including blood tube selection, pre- and post-processing time and temperature conditions, centrifugation conditions, freeze–thaw cycles, and long-term storage conditions are specifically discussed, with recommendations provided for best practices at each stage.
Peripheral Lipid Signatures, Metabolic Dysfunction, and Pathophysiology in Schizophrenia Spectrum Disorders
Authors: Wu Sally , Panganiban Kristoffer J. , Lee Jiwon , Li Dan , Smith Emily C.C. , Maksyutynska Kateryna , Humber Bailey , Ahmed Tariq , Agarwal Sri Mahavir , Ward Kristen , Hahn Margaret
Published: August 2024

Metabolic dysfunction is commonly observed in schizophrenia spectrum disorders (SSDs). The causes of metabolic comorbidity in SSDs are complex and include intrinsic or biological factors linked to the disorder, which are compounded by antipsychotic (AP) medications. The exact mechanisms underlying SSD pathophysiology and AP-induced metabolic dysfunction are unknown, but dysregulated lipid metabolism may play a role. Lipidomics, which detects lipid metabolites in a biological sample, represents an analytical tool to examine lipid metabolism. This systematic review aims to determine peripheral lipid signatures that are dysregulated among individuals with SSDs (1) with minimal exposure to APs and (2) during AP treatment. To accomplish this goal, we searched MEDLINE, Embase, and PsychINFO databases in February 2024 to identify all full-text articles written in English where the authors conducted lipidomics in SSDs. Lipid signatures reported to significantly differ in SSDs compared to controls or in relation to AP treatment and the direction of dysregulation were extracted as outcomes. We identified 46 studies that met our inclusion criteria. Most of the lipid metabolites that significantly differed in minimally AP-treated patients vs. controls comprised glycerophospholipids, which were mostly downregulated. In the AP-treated group vs. controls, the significantly different metabolites were primarily fatty acyls, which were dysregulated in conflicting directions between studies. In the pre-to-post AP-treated patients, the most impacted metabolites were glycerophospholipids and fatty acyls, which were found to be primarily upregulated and conflicting, respectively. These lipid metabolites may contribute to SSD pathophysiology and metabolic dysfunction through various mechanisms, including the modulation of inflammation, cellular membrane permeability, and metabolic signaling pathways.
The Impact of Varying Pasture Levels on the Metabolomic Profile of Bovine Ruminal Fluid
Authors: Connolly Claire , Timlin Mark , Hogan Sean A. , O’Callaghan Tom F. , Brodkorb André , O’Donovan Michael , Hennessy Deirdre , Fitzpatrick Ellen , McCarthy Kieran , Murphy John P. , Brennan Lorraine
Published: August 2024

A pasture or concentrate-based dietary regime impacts a variety of factors including both ruminal health and function, and consequently milk production and quality. The objective of this study was to examine the effect of feeding differing pasture levels on the metabolite composition of bovine ruminal fluid. Ruminal fluid was obtained from rumen-cannulated spring-calving cows (N = 9, Holstein-Friesian breed, average lactation number = 5) fed one of three diets across a full lactation season. Group 1 (pasture) consumed perennial ryegrass supplemented with 5% concentrates; group 2 received a total mixed ration (TMR) diet; and group 3 received a partial mixed ration (PMR) diet which included pasture and a TMR. Samples were taken at two timepoints: morning and evening. Metabolomic analysis was performed using nuclear magnetic resonance (1H-NMR) spectroscopy. Statistical analysis revealed significant changes across the dietary regimes in both morning and evening samples, with distinct alterations in the metabolite composition of ruminal fluid from pasture-fed cows (FDR-adjusted p-value < 0.05). Acetate and butyrate were significantly higher in samples derived from a pasture-based diet whereas sugar-related metabolites were higher in concentrate-based samples. Furthermore, a distinct diurnal impact on the metabolite profile was evident. This work lays the foundation for understanding the complex interaction between dietary regime and ruminal health.
Branch Waveguide Couplers with a frequency of 510 GHz for Terahertz Transmit/Receive Isolation Applications
Authors: Li Hao , Zhang Dehai , Meng Jin , Wang Li
Published: August 2024

To address the requirement of functioning as a transmit/receive isolation device in terahertz transceiver systems, in this paper, we present two high−isolation multi−branch waveguide directional couplers operating at a center frequency of 510 GHz. One is a high−performance five−branch directional coupler, and the other is a new type of three−branch waveguide coupler with lower processing difficulty. Both couplers were fabricated using low−cost CNC milling technologies. The performance of these couplers was verified through measurement results, demonstrating high isolation at the center frequency.
Ultra-Broadband Mode (De)Multiplexer on Thin-Film Lithium Niobate Platform Adopting Phase Control Theory
Authors: Yin Kun , Jiao Wenting , Wang Lin , Zhu Shiqiang
Published: August 2024

Mode (de)multiplexers (MDMs) serve as critical foundational elements within systems for facilitating high-capacity communication, relying on mode conversions achieved through directional coupler (DC) structures. However, DC structures are challenged by dispersion issues for broadband mode coupling, particularly for high-order modes. In this work, based on the principles of phase control theory, we have devised an approach to mitigate the dispersion challenges, focusing on a thin-film lithium niobate-on-onsulator (LNOI) platform. This solution involves integrating a customized inverse-dispersion section into the device architecture, offsetting minor phase shifts encountered during the mode coupling process. By employing this approach, we have achieved broadband mode conversion from TE0 to TE1 and TE0 to TE2 within a 300 nm wavelength range, and the maximum deviations were maintained below −0.68 dB and −0.78 dB, respectively. Furthermore, the device exhibited remarkably low crosstalk, reaching down to −26 dB.
Off-Stoichiometry Thiol-Ene (OSTE) Micro Mushroom Forest: A Superhydrophobic Substrate
Authors: Li Haonan , Zhang Muyang , Liu Yeqian , Yu Shangneng , Li Xionghui , Chen Zejingqiu , Feng Zitao , Zhou Jie , He Qinghao , Chen Xinyi , Zhang Huiru , Zhang Jiaen , Zhang Xingwei , Guo Weijin
Published: August 2024

Superhydrophobic surfaces have been used in various fields of engineering due to their resistance to corrosion and fouling and their ability to control fluid movement. Traditionally, superhydrophobic surfaces are fabricated via chemical methods of changing the surface energy or mechanical methods of controlling the surface topology. Many of the conventional mechanical methods use a top-to-bottom scheme to control the surface topolopy. Here, we develop a novel fabrication method of superhydrophobic substrates using a bottom-to-top scheme via polymer OSTE, which is a prototyping polymer material developed for the fabrication of microchips due to its superior photocuring ability, mechanical properties, and surface modification ability. We fabricate a superhydrophobic substrate by OSTE–OSTE micro mushroom forest via a two-step lithography process. At first, we fabricate an OSTE pillar forest as the mushroom stems; then, we fabricate the mushroom heads via backside lithography with diffused UV light. Such topology and surface properties of OSTE render these structures superhydrophobic, with water droplets reaching a contact angle of 152.9 ± 0.2°, a sliding angle of 4.1°, and a contact angle hysteresis of less than 0.5°. These characteristics indicate the promising potential of this substrate for superhydrophobic applications.
Response of Escherichia coli to Acid Stress: Mechanisms and Applications—A Narrative Review
Authors: Li Zepeng , Huang Zhaosong , Gu Pengfei
Published: August 2024

Change in pH in growth conditions is the primary stress for most neutralophilic bacteria, including model microorganism Escherichia coli. However, different survival capacities under acid stress in different bacteria are ubiquitous. Research on different acid-tolerance mechanisms in microorganisms is important for the field of combating harmful gut bacteria and promoting fermentation performance of industrial strains. Therefore, this study aimed to carry out a narrative review of acid-stress response mechanism of E. coli discovered so far, including six AR systems, cell membrane protection, and macromolecular repair. In addition, the application of acid-tolerant E. coli in industry was illustrated, such as production of industrial organic acid and developing bioprocessing for industrial wastes. Identifying these aspects will open the opportunity for discussing development aspects for subsequent research of acid-tolerant mechanisms and application in E. coli.
Molecular Screening and Genetic Identification of Anaplasma platys in Brown Dog Tick (Rhipicephalus sanguineus s. l.) Infested on Stray Dogs in Taiwan
Authors: Chao Li-Lian , Ko Pei-Yin , Shih Chien-Ming
Published: August 2024

Anaplasma platys is a tick-borne zoonotic pathogen of canines. In this study, the presence of A. platys was screened for in brown dog ticks (Rhipicephalus sanguineus s. l.) infesting stray dogs in Taiwan to determine overall prevalence. This study represents the first instance of genetic identification of A. platys in brown dog ticks in Taiwan. In total, we examined 324 brown dog ticks for A. platys infection by nested polymerase chain reaction assay targeting the 16S ribosomal RNA gene. The general prevalence of A. platys infection was 3.1%, with 3.6%, 4.0%, and 2.1% in nymph, female, and male ticks, respectively. Monthly prevalence of infection was observed from May to September. Genetic relatedness was determined by comparing the sequences of the 16S rRNA gene obtained from six Taiwan strains and seventeen other strains, representing six genospecies of Anaplasma spp. and three outgroups (Ehrlichia canis, Rickettsia rickettsia, and Escherichia coli). All Taiwan specimens were shown to genetically belong to the A. platys group, and could be clearly discriminated from other Anaplasma spp. Genetic similarities revealed a 100% identity match with various A. platys documented in GenBank. This study highlights the epidemiological importance of geographical transmission of A. platys among dogs and the possible risk for human infections in Taiwan.
Plants with Antimicrobial Activity against Escherichia coli, a Meta-Analysis for Green Veterinary Pharmacology Applications
Authors: De Fazio Rosario , Oppedisano Francesca , Caioni Giulia , Tilocca Bruno , Piras Cristian , Britti Domenico
Published: August 2024

Antimicrobial resistance (AMR) poses a critical global health threat, necessitating innovative strategies to combat infectious diseases. Plants and their extracts offer alternatives/support to traditional antibiotics, and their diverse phytocomplexes with antimicrobial properties can be exploited. The Mediterranean hosts a high number of biodiverse plant species known for their bioactive compounds. This study focuses on identifying plant species and phytochemical constituents with antimicrobial activity against Escherichia coli (E. coli). Utilizing a systematic literature review and meta-analysis approach, we screened 3037 entries, yielding 70 studies suitable for MIC (minimum inhibitory concentration) annotation. The results highlighted Lavandula spp., Plectranthus spp. and Lupinus jaimehintoniana as the most effective plants with average MICs of, respectively, 0.144 mg/mL, 0.260 mg/mL, and 0.140 mg/mL. These results might help to fight AMR via the discovery of complementary natural antimicrobial agents to support the development of green veterinary pharmacology. Further exploration of these resources promises valuable insights for future support to antimicrobial strategies.
Utilizing Magnesium Carbonate Induced by CO2 to Modify the Performance of Plastic Clay
Authors: Mohamadzadeh Romiani Hadi , Keykha Hamed Abdeh , Chegini Saeed , Asadi Afshin , Kawasaki Satoru
Published: August 2024

Highly plastic clays pose significant challenges in engineering projects. Various techniques have been employed to enhance their properties, though many face difficulties related to implementation and environmental impact. This study examines the effect of CO2-induced magnesium carbonate on improving the geotechnical behavior of plastic clay. CO2-induced magnesium carbonate was produced via mineral carbonation and used to improve the behavior of highly plastic natural clay. CO2 gas was injected into a sodium hydroxide solution to produce carbonate ions (CO32−). Magnesium carbonate was precipitated on a laboratory scale by adding magnesium sulfate solution to the carbonate ion solution. Clayey soil samples were obtained from test pits in the Meyghan Plain near Arak, Iran. The clay samples were treated with different percentages of the produced magnesium carbonate. Various parameters of the treated and untreated samples, including index properties, unconfined compressive strength, consolidation behavior, and swelling potential, were studied. It was found that the liquid limit and plasticity index of the treated clay decreased as the magnesium carbonate content increased. The soil classification changed from high plastic clay (CH) to low plastic silt (ML) with the addition of 15% magnesium carbonate to the highly plastic clay. The unconfined compressive strength of the treated clay increased. Additionally, the consolidation behavior and swelling index of the treated clay improved as the magnesium carbonate content increased. This study confirms that CO2-induced magnesium carbonate is a promising material for improving the behavior of highly plastic clays, offering a sustainable approach to environmental management.
Abiotic and Biotic Processes Controlling Deposition of Calcite and Hydrotalcite Calcretes on Niue Island, Southwest Pacific
Authors: Aharon Paul , Whitehead Neil E.
Published: August 2024

Calcretes are indurated terrestrial carbonates that are widespread in arid and semi-arid settings and serve as important archives of present and past environments. Here, we use geochemical tools to explore the nature and origin of calcretes documented from tropical Niue Island in the Southwest Pacific. The study recognizes two types of calcretes that differ in their mineral assemblage, microfabrics, elemental chemistry, and carbon and oxygen isotopes. The calcretes common in the paleo-lagoon soils consist of 90% low-Mg calcite and ~10% highly weathered Mg-Al silicates. These pedogenic calcretes formed in the soil profiles within the vadose zone bear the following distinctions: (i) Fe/Al ratio of 0.75, identical to the ratio in soils (Fe/Al = 0.76 ± 0.5), substantiating the link between the calcretes and soils; (ii) presence of rhizoliths, root voids, micritic nodules, and clasts, which are consistent with a pedogenic calcrete fabric; and (iii) 13C and 18O depletions of −10.6‰ and −5.3‰, respectively, which are compatible with carbon sources from microbial and root respiration, as well as formation in oxygen isotope equilibrium with vadose waters. Unlike the pedogenic calcrete, a rare calcrete from the coastal terrace contains an exceptionally rare hydrotalcite [Mg6Al2(CO3)(OH)16(H2O)4] mineral (65%) coated by microbial films. We contend that the hydrotalcite-rich calcrete was deposited through interaction of dolomite with seawater, similar to the method of producing hydrotalcite in the laboratory. 13C and 18O enrichments of 0.8 to 1.7‰ and −1.0 to −1.6‰, respectively, are in agreement with (i) mixed carbon sources consisting of microbial CO2 degassing, seawater HCO3, and dolomite dissolution, and (ii) oxygen isotope equilibration with seawater-derived fluid.