bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 1 from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: March 2023

Supplementary Figure 1. This figure shows validation of H358 and H441 Brg1 knockdown cell lines.
Data Supplement from IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Authors: Venmar Katherine T. , Carter Kathy J. , Hwang Daniel G. , Dozier E. Ashley , Fingleton Barbara
Published: March 2023

Supplemental Figure 2: Immunohistochemical analysis of survival and proliferation in lung and liver metastases
Supplementary Figure S5 from Selective In Vivo Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe
Authors: Stangl Stefan , Varga Julia , Freysoldt Bianca , Trajkovic-Arsic Marija , Siveke Jens T. , Greten Florian R. , Ntziachristos Vasilis , Multhoff Gabriele
Published: March 2023

Supplemental Figures S5A,B,C. Figure S5A: NIRF imaging of CT26 tumors (s.c.) and tumor to background ratios (TBR). Figure S5B: NIRF imaging of 4T1 tumors (o.t.)and TBR. Figure S5C: NIRF imaging of 4T1-derived metastases and TBR.
Supplementary Figure Legend from Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL
Authors: Richards Kristy L. , Motsinger-Reif Alison A. , Chen Hsiao-Wei , Fedoriw Yuri , Fan Cheng , Nielsen Dahlia M. , Small George W. , Thomas Rachael , Smith Chris , Dave Sandeep S. , Perou Charles M. , Breen Matthew , Borst Luke B. , Suter Steven E.
Published: March 2023

PDF file - 60K
Supplemental Table S2 from Novel Paracrine Modulation of Notch–DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas
Authors: Nandhu Mohan S. , Hu Bin , Cole Susan E. , Erdreich-Epstein Anat , Rodriguez-Gil Diego J. , Viapiano Mariano S.
Published: March 2023

Sequences used for siRNA and semiquantitative RT-PCR primers.
Supplementary Figure S1 from CtBP2 Modulates the Androgen Receptor to Promote Prostate Cancer Progression
Authors: Takayama Ken-ichi , Suzuki Takashi , Fujimura Tetsuya , Urano Tomohiko , Takahashi Satoru , Homma Yukio , Inoue Satoshi
Published: March 2023

Supplementary Figure S1. CtBP2 is induced by androgen treatment.
Supplementary Video #5 from Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform
Authors: Wong Andrew D. , Searson Peter C.
Published: March 2023

A single MDA-MB-231 breast cancer cell invading and intravasating into an HMVEC vessel under shear stress (12-15 dyne cm-2).
Supplementary Figure Legends from Molecular Modulation of Estrogen-Induced Apoptosis by Synthetic Progestins in Hormone Replacement Therapy: An Insight into the Women's Health Initiative Study
Authors: Sweeney Elizabeth E. , Fan Ping , Jordan V. Craig
Published: March 2023

Supplementary Figure Legends. Supplementary Figure Legends
Supplementary Figure 7. Effects of progestin, MPA, and Dex on E2-stimulated growth in MCF-7:WS8 cells. from Molecular Modulation of Estrogen-Induced Apoptosis by Synthetic Progestins in Hormone Replacement Therapy: An Insight into the Women's Health Initiative Study
Authors: Sweeney Elizabeth E. , Fan Ping , Jordan V. Craig
Published: March 2023

Supplementary Figure 6. MCF-8:WS8 cells were transferred to estrogen-free medium for 3 days. The, cells were loaded in 24-well plates. A. MCF-7:WS8 cells were treated with vehicle, 0.01µM R5020, 1nM E2, and 0.01µM R5020+1nM E2. Cells were harvested after 7 days treatment and DNA was quantified. P<0.05, * compared with control. P<0.001, ** compared with control. B. MCF-7:WS8 cells were treated with vehicle, different concentrations of MPA as indicated, 1nM E2, and different concentrations of MPA+1nM E2. Cells were harvested after 7 days treatment and DNA was quantified. P<0.05, * compared with E2-treated group. P<0.001, ** compared with control. C. MCF-7:WS8 cells were treated with vehicle, different concentrations of Dex as indicated, 1nM E2, and different concentrations of Dex+1nM E2. Cells were harvested after 7 days treatment and DNA was quantified. P<0.05, * compared with E2-treated group. P<0.001, ** compared with control.
Supplementary Figure 6 from Molecular Modulation of Estrogen-Induced Apoptosis by Synthetic Progestins in Hormone Replacement Therapy: An Insight into the Women's Health Initiative Study
Authors: Sweeney Elizabeth E. , Fan Ping , Jordan V. Craig
Published: March 2023

Supplementary Figure 6. A. MCF-7:WS8 cells were transfected with an ERE-luciferase reporter construct for 24 hours, then treated with vehicle, 1µM ICI, 1µM R5020, 1µM RU486, 1nM E2, 1µM MPA, 1µM NETA, or combinations for 24 hours. ERE activity was measured by luciferase assay and normalized to vehicle control. Means represent samples in triplicate. B. MCF-7:WS8 cells were transfected with an ERE-luciferase reporter construct for 24 hours, then treated with vehicle, 1µM 4-OHT, 1µM R5020, 1µM RU486, 1nM E2, 1µM MPA, 1µM NETA, or combinations for 24 hours. ERE activity was measured by luciferase assay and normalized to vehicle control. Means represent samples in triplicate. Error bars too small to visualize.
Supplemental Figure S2 from Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer
Authors: Tran Hung D. , Luitel Krishna , Kim Michael , Zhang Kun , Longmore Gregory D. , Tran David D.
Published: March 2023

Supplemental Figure S2. Related to Figure 2A-E: SNAIL1 expression in primary breast tumors strongly correlates with increased metastasis in MMTV-neuNT mice
Supplemental Figures 1 - 8 from Antitumor Efficacy of a Bispecific Antibody That Targets HER2 and Activates T Cells
Authors: Junttila Teemu T. , Li Ji , Johnston Jennifer , Hristopoulos Maria , Clark Robyn , Ellerman Diego , Wang Bu-Er , Li Yijin , Mathieu Mary , Li Guangmin , Young Judy , Luis Elizabeth , Lewis Phillips Gail , Stefanich Eric , Spiess Christoph , Polson Andrew , Irving Bryan , Scheer Justin M. , Junttila Melissa R. , Dennis Mark S. , Kelley Robert , Totpal Klara , Ebens Allen
Published: March 2023

Supplemental Fig. 1: Characteristics of T cell activation and killing induced by HER2-TDB. Supplemental Fig 2: Activation of T cells by HER2-TDB induces T cell proliferation. Supplemental Figure 3. Activity of HER2-TDB in NOD-SCID mice is dependent on human PBMCs. Supplemental Figure 4. TDB mediated killing by CD3-TG splenic T cells. Supplemental Figure 5. Effect of 4D5 on established mammary tumors in MMTV-huHER2 transgenic mice. CD3-TG T cells express both mouse and human CD3 on approximately 50% level of respective Balb/c mouse or human T cells. Supplemental Figure 6. Anti-tumor activity of HER2-TDB is T cell dependent. Supplemental Figure 7. T cells in CT26-HER2 tumors display CD69 activation marker. Supplemental Figure 8. CT-26-HER2 tumor infiltrating T cells express PD-1. CT-26-HER2 tumor cells express PD-L1.
Supplementary Methods from Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel
Authors: Nieuweboer Annemieke J.M. , Hu Shuiying , Gui Chunshan , Hagenbuch Bruno , Ghobadi Moghaddam-Helmantel Inge M. , Gibson Alice A. , de Bruijn Peter , Mathijssen Ron H.J. , Sparreboom Alex
Published: March 2023

PDF file - 58KB
Supplementary Methods from A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Authors: Fujimura Ken , Wright Tracy , Strnadel Jan , Kaushal Sharmeela , Metildi Cristina , Lowy Andrew M. , Bouvet Michael , Kelber Jonathan A. , Klemke Richard L.
Published: March 2023

Contains detailed description of materials and methods.
Supplementary Figure 5 from A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Authors: Fujimura Ken , Wright Tracy , Strnadel Jan , Kaushal Sharmeela , Metildi Cristina , Lowy Andrew M. , Bouvet Michael , Kelber Jonathan A. , Klemke Richard L.
Published: March 2023

Contains Oncomine data.
Data Supplement from CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models
Authors: Zhu Yu , Knolhoff Brett L. , Meyer Melissa A. , Nywening Timothy M. , West Brian L. , Luo Jingqin , Wang-Gillam Andrea , Goedegebuure S. Peter , Linehan David C. , DeNardo David G.
Published: March 2023

Figure S1. Flow cytometric analysis of leukocyte infiltration in orthotopic PDAC tumors. Figure S2. CSF1 blockade depletes CD206+ Mo-MDSCs and upregulates MHCII expression in Lymphoid DCs. Figure S3. A-B) Mice bearing orthotopic KC. Table S1. Gene lists from array analysis are depicted. Lists were selected by fold change > or < 1.5, pvalue <0.05, and q-value <0.25. n=6 mice/group for a total of 12 arrays.
Supplementary Figure 4 from A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Authors: Fujimura Ken , Wright Tracy , Strnadel Jan , Kaushal Sharmeela , Metildi Cristina , Lowy Andrew M. , Bouvet Michael , Kelber Jonathan A. , Klemke Richard L.
Published: March 2023

Contains additional data on PEAK1 expression and gemcitabine sensitivity.
Supplementary Figure 3 from A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Authors: Fujimura Ken , Wright Tracy , Strnadel Jan , Kaushal Sharmeela , Metildi Cristina , Lowy Andrew M. , Bouvet Michael , Kelber Jonathan A. , Klemke Richard L.
Published: March 2023

Contains additional data on in vitro and in vivo growth of PDAC cells with eIF5A knockdown or overexpression.
Supplementary Figure Legends from EGFR Blockade Enriches for Lung Cancer Stem–like Cells through Notch3-Dependent Signaling
Authors: Arasada Rajeswara Rao , Amann Joseph M. , Rahman Mohammad A. , Huppert Stacey S. , Carbone David P.
Published: March 2023

Supplementary Figure legends
Supplementary Methods, Figure Legends from Targeting of miR34a–NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance
Authors: Park Eun Young , Chang EunSun , Lee Eun Ji , Lee Hyun-Woo , Kang Hyeok-Gu , Chun Kyung-Hee , Woo Yu Mi , Kong Hyun Kyung , Ko Je Yeong , Suzuki Hiromu , Song Erwei , Park Jong Hoon
Published: March 2023

Supplementary Methods, Figure Legends
Supplementary Figure 2 from Targeting of miR34a–NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance
Authors: Park Eun Young , Chang EunSun , Lee Eun Ji , Lee Hyun-Woo , Kang Hyeok-Gu , Chun Kyung-Hee , Woo Yu Mi , Kong Hyun Kyung , Ko Je Yeong , Suzuki Hiromu , Song Erwei , Park Jong Hoon
Published: March 2023

Supplementary Figure 2. Expression levels of Notch family in tumorsphere cells.
Supplementary Video 1 from Deubiquitination of γ-Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells
Authors: Zarrizi Reihaneh , Menard Julien Albert , Belting Mattias , Massoumi Ramin
Published: March 2023

Live cell microscopy of MDA-MB-468 inducibly expressing FLAG-HA-BAP1 and transiently transfected with H2B-GFP.
Supplementary Methods from Deubiquitination of γ-Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells
Authors: Zarrizi Reihaneh , Menard Julien Albert , Belting Mattias , Massoumi Ramin
Published: March 2023

Supplementary materials and methods.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: March 2023

Supplementary Figure S2. Gal-1 expression is positively correlated with histological grade in human glioma.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: March 2023

Supplementary Figure S7. Anti-CD3ÃŽÂµ immunolabeled brain tissue sections from mouse A1 (top image) and mouse N2 (bottom image) shown in Figure 5I.
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Authors: von Roemeling Christina A. , Radisky Derek C. , Marlow Laura A. , Cooper Simon J. , Grebe Stefan K. , Anastasiadis Panagiotis Z. , Tun Han W. , Copland John A.
Published: March 2023

Supplementary Figure 1. (A) QPCR for NPTX2 expression in an array of normal (n=4) and ccRCC (n=7) cell lines. All samples are normalized to a water negative control. Four shRNA lentiviral constructs (sh804, sh855, sh1316, sh1623) against NPTX2 were used to infect A498 cells. (B) Description of ccRCC cell line VHL mutational status. (C) QPCR for NPTX2 mRNA in each of the A498 NT vs. target lentiviral clones. (D) Western blot analysis for NPTX2 protein expression in all four A498 NPTX2 shRNA clones compared to NT control. Protein expression level quantitation is normalized to β-actin. (E) Proliferation (7 day) rescue assay of A498 cells transfected with either a human NPTX2 expression vector (+NPTX2) plasmid or empty vector (EV) control, and infected with NT control, sh1316 or sh1623 NPTX2 targeting lentivirus.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: March 2023

Supplementary Figure S8. Splenic-derived RAG1-/- NK cell purity assessment.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: March 2023

Legend for Supplementary Figures S1-S8.
Supplemental Figure 2. Cerenkov Light Images of excised organs. from In Vivo Localization of 90Y and 177Lu Radioimmunoconjugates Using Cerenkov Luminescence Imaging in a Disseminated Murine Leukemia Model
Authors: Balkin Ethan R. , Kenoyer Aimee , Orozco Johnnie J. , Hernandez Alexandra , Shadman Mazyar , Fisher Darrell R. , Green Damian J. , Hylarides Mark D. , Press Oliver W. , Wilbur D. Scott , Pagel John M.
Published: March 2023

Supplemental Figure 2. Cerenkov Light Images of excised organs. Groups of 5 mice were given 300 µCi on 100 µg of 90Y-DOTA-30F11 (A), 177Lu-DOTA-30F11 (B), 90Y-DOTA-Rat IgG (C), or 177Lu-DOTA-Rat IgG (D). Groups of mice were harvested and images collected at 4, 24, 48, and 72 hours post-injection, immediately prior to gamma counting of the tissues. By 24 hours post-injection, there was little or no detectable signal in non-target organs and tissues.
Supplemental Figures S1-S8 from AEG-1 Promoter–Mediated Imaging of Prostate Cancer
Authors: Bhatnagar Akrita , Wang Yuchuan , Mease Ronnie C. , Gabrielson Matthew , Sysa Polina , Minn Il , Green Gilbert , Simmons Brian , Gabrielson Kathleen , Sarkar Siddik , Fisher Paul B. , Pomper Martin G.
Published: March 2023

S1: Schematic maps of AEG-Prom and PEG-Prom reporter constructs S2: c-MYC protein levels analyzed in prostate cancer cell lines by western blotting using anti-MYC antibody (57-70 kDa) S3: Time course for model maturation with PC3-ML-Luc cells using bioluminescence imaging (BLI) at week 5 after injection of: (A) 5 x 104 cells (intracardiac); (B) 1 x 106 cells (tail vein) S4: Cancer-specific AEG-Prom and PEG-Prom activity shown by bioluminescence imaging (BLI) in an experimental model of human prostate cancer (PC3-ML) S5: Comparison of Luc plasmid delivery to lungs of the PCa group for pAEG-Luc treated and pPEG-Luc treated animals (n = 3, PCa-1-3 in Supplemental Fig. S4), respectively S6: Correlation between AEG-1 promoter-driven Luc expression and metastatic sites by histopathological analysis in a bone metastatic prostate cancer model of prostate cancer metastasis S7: Cancer-Specific AEG-Prom activity shown by bioluminescence imaging (BLI) in experimental models of human prostate cancer (PC3-ML) S8: AEG-Prom-based SPECT/CT imaging detects distant metastasis not identified by NaF- or FDG-PET/CT
Figure S6 from Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Authors: Tao Shasha , Wang Shue , Moghaddam Seyed Javad , Ooi Aikseng , Chapman Eli , Wong Pak K. , Zhang Donna D.
Published: March 2023

Figure S6. Larger images of the IHC analysis shown in Figure 5D, right panel.
Data Supplement from TRIB1 Supports Prostate Tumorigenesis and Tumor-Propagating Cell Survival by Regulation of Endoplasmic Reticulum Chaperone Expression
Authors: Mashima Tetsuo , Soma-Nagae Taeko , Migita Toshiro , Kinoshita Ryoko , Iwamoto Atsushi , Yuasa Takeshi , Yonese Junji , Ishikawa Yuichi , Seimiya Hiroyuki
Published: March 2023

Supplementary Figure 1 shows analysis of TRIB1 expression in clinical prostate cancer specimens using Oncomine and cBioPortal database. Supplementary Figure 2 shows TRIB1 expression in prostate cancer cell lines and the effect of TRIB1 knockdown on the morphology of the prostate cancer cells. Supplementary Figure 3 shows TRIB1 knockdown in prostate cancer cell lines and the effect of TRIB1 overexpression on anchorage-independent cell growth. Supplementary Figure 4 shows that TRIB1 does not affect ERK phosphorylation or the C/EBP proteins. Supplementary Figure 5 shows subcellular localization of TRIB1, role of GRP78 in 2D and 3D cell survival, and regulation of GRP78 expression by TRIB1. Supplementary Figure 6 shows typical staining patterns of TRIB1 and the ER chaperone in human prostate cancer tissues. Supplementary Figure 7 shows analysis of the tumor-propagating cell population in patient-derived prostate cancer primary cultures.
Supplemental Table S1 from Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer
Authors: Geng Chuandong , Rajapakshe Kimal , Shah Shrijal S. , Shou John , Eedunuri Vijay Kumar , Foley Christopher , Fiskus Warren , Rajendran Mahitha , Chew Sue Anne , Zimmermann Martin , Bond Richard , He Bin , Coarfa Cristian , Mitsiades Nicholas
Published: March 2023

Primers used for PCR cloning and qPCR assays.
SuppFigure1 from Changes in Pyruvate Metabolism Detected by Magnetic Resonance Imaging Are Linked to DNA Damage and Serve as a Sensor of Temozolomide Response in Glioblastoma Cells
Authors: Park Ilwoo , Mukherjee Joydeep , Ito Motokazu , Chaumeil Myriam M. , Jalbert Llewellyn E. , Gaensler Karin , Ronen Sabrina M. , Nelson Sarah J. , Pieper Russell O.
Published: March 2023

SuppFigure1. Representative hyperpolarized 13C MRSI data shows T1 post-Gd images,13C spectra, and Lac/Pyr overlay map of tumor-bearing animals (U87 or U87+MGMT) at D0, D1 and D2 following TMZ (100 mg/kg) treatment. Lac/Pyr dropped with TMZ-treatment beginning at D1 in MGMT-deficient treated tumors (U87+TMZ) while all the other groups exhibited increased Lac/Pyr. Yellow boxes, tumor.
Supplemental Methods and References from Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer
Authors: Geng Chuandong , Rajapakshe Kimal , Shah Shrijal S. , Shou John , Eedunuri Vijay Kumar , Foley Christopher , Fiskus Warren , Rajendran Mahitha , Chew Sue Anne , Zimmermann Martin , Bond Richard , He Bin , Coarfa Cristian , Mitsiades Nicholas
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplemental References.
Supplementary Figures 1 - 6, Table 1, Methods from Pro-Oncogenic Role of Alternative p38 Mitogen-Activated Protein Kinases p38γ and p38δ, Linking Inflammation and Cancer in Colitis-Associated Colon Cancer
Authors: del Reino Paloma , Alsina-Beauchamp Dayanira , Escós Alejandra , Cerezo-Guisado Ma Isabel , Risco Ana , Aparicio Noelia , Zur Rafal , Fernandez-Estévez Marian , Collantes Elena , Montans Jose , Cuenda Ana
Published: March 2023

Figure S1. Effect of p38gamma and p38delta deletion in early stages of colitis-associated colon cancer induced by AOM/DSS treatment. Figure S2. p38gamma and p38deltaexpression in AOM/DSS-treated and untreated mouse colon. WT, p38gamma /-, p38delta/- or p38gamma/delta/- mice were AOM/DSS-treated and untreated. At 9 weeks post-AOM injection, colon extracts were prepared for mRNA and protein analysis. Figure S3. p38gamma or p38deltadeletion has no significant effect on body weight and colon length in the course of DSS-induced colitis. WT and p38gamma/delta/- mice were treated with 3% DSS in drinking water for 5 days. Figure S4. p38gamma/delta-/- mice show increased IEC apoptosis after DSS treatment. Figure S5. ERK1/2 phosphorylation, but not IkappaBalpha proteolysis, was reduced in p38gamma/delta-/- colon cells compared to WT. Figure S6. Effect of p38gamma/deltadeletion in the expression of chemokine receptors and in the recruitment of neutrophils, macrophages and Treg cells. Table SI. Primer sequences used for gene expression.
Figure S1 from PELP1 Overexpression in the Mouse Mammary Gland Results in the Development of Hyperplasia and Carcinoma
Authors: Cortez Valerie , Samayoa Cathy , Zamora Andrea , Martinez Lizatte , Tekmal Rajeshwar R. , Vadlamudi Ratna K.
Published: March 2023

Figure S1. Characterization of PELP1 Tg mice
Supplementary Figure Legend from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling
Authors: Gao Shan , Bajrami Ilirjana , Verrill Clare , Kigozi Asha , Ouaret Djamila , Aleksic Tamara , Asher Ruth , Han Cheng , Allen Paul , Bailey Deborah , Feller Stephan , Kashima Takeshi , Athanasou Nicholas , Blay Jean-Yves , Schmitz Sandra , Machiels Jean-Pascal , Upile Nav , Jones Terry M. , Thalmann George , Ashraf Shazad Q. , Wilding Jennifer L. , Bodmer Walter F. , Middleton Mark R. , Ashworth Alan , Lord Christopher J. , Macaulay Valentine M.
Published: March 2023

Supplementary Figure Legend. Legends for Supplementary Figures S1-S6.
Supplementary Table 3 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling
Authors: Schoumacher Marie , Hurov Kristen E. , Lehár Joseph , Yan-Neale Yan , Mishina Yuji , Sonkin Dmitriy , Korn Joshua M. , Flemming Daisy , Jones Michael D. , Antonakos Brandon , Cooke Vesselina G. , Steiger Janine , Ledell Jebediah , Stump Mark D. , Sellers William R. , Danial Nika N. , Shao Wenlin
Published: March 2023

XLSX file - 234KB, This table shows the features of all 138 cancer cell lines tested for the TNKSi/MEKi combination in the unbiased combination screen. Cell line name, lineage, RAS mutation status and synergy score for the TNKSi/MEKi combination are represented. Cell lines are ranked according to their synergy score.
Supplementary Figure Legends from The Notch Pathway Inhibits TGFβ Signaling in Breast Cancer through HEYL-Mediated Crosstalk
Authors: Han Liangfeng , Diehl Adam , Nguyen Nguyen K. , Korangath Preethi , Teo Weiwen , Cho Soonweng , Kominsky Scott , Huso David L. , Feigenbaum Lionel , Rein Alan , Argani Pedram , Landberg Goran , Gessler Manfred , Sukumar Saraswati
Published: March 2023

Supplementary Figure Legends. Legend for Supplementary Figures S1-S10.
Supplementary Information from Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis
Authors: Menard Julien A. , Christianson Helena C. , Kucharzewska Paulina , Bourseau-Guilmain Erika , Svensson Katrin J. , Lindqvist Eva , Chandran Vineesh Indira , Kjellén Lena , Welinder Charlotte , Bengzon Johan , Johansson Maria C. , Belting Mattias
Published: March 2023

Supplementary Materials & Methods.
Data Supplement from The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Authors: Corbet Cyril , Draoui Nihed , Polet Florence , Pinto Adan , Drozak Xavier , Riant Olivier , Feron Olivier
Published: March 2023

Supplementary Figure S1. Chronic acidosis causes a metabolic switch from glucose to glutamine utilization in FaDu and HCT-116 tumor cells.
Data Supplement from RB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes
Authors: Vormer Tinke L. , Wojciechowicz Kamila , Dekker Marleen , de Vries Sandra , van der Wal Anja , Delzenne-Goette Elly , Naik Sjalin H. , Song Ji-Ying , Dannenberg Jan-Hermen , Hansen Jacob B. , te Riele Hein
Published: March 2023

Supplementary Table S3. FACS analysis of bone marrow of Rb/p130 mutant mice.
Supplementary Table 1 from Activated d16HER2 Homodimers and SRC Kinase Mediate Optimal Efficacy for Trastuzumab
Authors: Castagnoli Lorenzo , Iezzi Manuela , Ghedini Gaia C. , Ciravolo Valentina , Marzano Giulia , Lamolinara Alessia , Zappasodi Roberta , Gasparini Patrizia , Campiglio Manuela , Amici Augusto , Chiodoni Claudia , Palladini Arianna , Lollini Pier Luigi , Triulzi Tiziana , Menard Sylvie , Nanni Patrizia , Tagliabue Elda , Pupa Serenella M.
Published: March 2023

HER2-positive BC patient pathobiological and clinical characteristics.
Supplemental Table 2 from Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate
Authors: Rubashkin Matthew G. , Cassereau Luke , Bainer Russell , DuFort Christopher C. , Yui Yoshihiro , Ou Guanqing , Paszek Matthew J. , Davidson Michael W. , Chen Yunn-Yi , Weaver Valerie M.
Published: March 2023

List of Cancer Tissue with Unbiased Matched Normal Tissue used in Bioinformatics Analysis.
Data Supplement from Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors
Authors: Nishio Nobuhiro , Diaconu Iulia , Liu Hao , Cerullo Vincenzo , Caruana Ignazio , Hoyos Valentina , Bouchier-Hayes Lisa , Savoldo Barbara , Dotti Gianpietro
Published: March 2023

Supplementary Table S1. Chemokine production of NB cells
Data Supplement from Molecular Imaging with Bioluminescence and PET Reveals Viral Oncolysis Kinetics and Tumor Viability
Authors: Kuruppu Darshini , Brownell Anna-Liisa , Shah Khalid , Mahmood Umar , Tanabe Kenneth K.
Published: March 2023

Supplemental Figure 2: Tumor growth and viral replication kinetics imaged with dual bioluminescence S2A: MC26-Rluc flank tumor growth imaged with Rluc bioluminescence. S2B: The fate of MC26-Rluc tumors undergoing viral oncolysis imaged with Rluc bioluminescence. S2C: Rluc bioluminescence signal intensities (expressed as mean net intensity/area +/- SD) in the control and treated groups. S2D: Volumetric measurements in the control and virus treated groups obtained with caliper readings. Tumor volume is expressed as the mean +/- SD. S2E: Virus replication imaged with Fluc bioluminescence. S2F: Virus replication quantified with Fluc signal intensities (expressed as mean net intensity/area +/- SD) showed several peaks (arrows) in the curve as the signal intensity decreased over time.
Supplementary Figure S3 from Phosphoinositide Protein Kinase PDPK1 Is a Crucial Cell Signaling Mediator in Multiple Myeloma
Authors: Chinen Yoshiaki , Kuroda Junya , Shimura Yuji , Nagoshi Hisao , Kiyota Miki , Yamamoto-Sugitani Mio , Mizutani Shinsuke , Sakamoto Natsumi , Ri Masaki , Kawata Eri , Kobayashi Tsutomu , Matsumoto Yosuke , Horiike Shigeo , Iida Shinsuke , Taniwaki Masafumi
Published: March 2023

Supplementary Figure S3. AMO-1 cells and NCI-H929 cells were co-cultured with HS-5 cells for 48 hours, and then were treated by BX-912 at its IC50s for 3 hours. The activities of PDPK1Ser241, RSK2Ser227 and AKTThr308 were examined by Western blotting. Ctl. indicates cells cultured without the co-culture.
Supplementary Figure S2 from Phosphoinositide Protein Kinase PDPK1 Is a Crucial Cell Signaling Mediator in Multiple Myeloma
Authors: Chinen Yoshiaki , Kuroda Junya , Shimura Yuji , Nagoshi Hisao , Kiyota Miki , Yamamoto-Sugitani Mio , Mizutani Shinsuke , Sakamoto Natsumi , Ri Masaki , Kawata Eri , Kobayashi Tsutomu , Matsumoto Yosuke , Horiike Shigeo , Iida Shinsuke , Taniwaki Masafumi
Published: March 2023

Supplementary Figure S2. A, DNA content was examined by propidium iodide (PI)-staining of formalin-fixed cells using flow cytometric analysis. The X-axis represents DNA content, and the Y-axis represents the relative cell numbers. AR-12 (AR) treatment reduced G1 population (light green fraction) and increased the subG1 fraction, a hallmark of apoptosis induction (indicated by arrow), in the myeloma AMO-1 and NCI-H929 cell lines. AMO-1 and NCI-H929 cells were treated with AR at their IC80 concentrations for 12 and 24 hours. B, AMO-1 and NCI-H929 cells were treated with AR at their IC80 concentrations for 6 to 12 hours, and were subjected to double staining for Annexin-V (X-axis) and PI (Y-axis). AR treatment caused the increase of cells undergoing early apoptosis (Annexin-V-positive/PI-negative fraction) first, and, then, resulted in the increase of cells undergoing late apoptosis (double positive for Annexin-V and PI) in both AMO-1 cells and NCI-H929 cells.
Supplemental Movie 1 from AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
Authors: Wilson Catherine , Ye Xiaofen , Pham Thinh , Lin Eva , Chan Sara , McNamara Erin , Neve Richard M. , Belmont Lisa , Koeppen Hartmut , Yauch Robert L. , Ashkenazi Avi , Settleman Jeff
Published: March 2023

Timelapse movie of HeLa cells treated with DMSO.
Supplemental Text from ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
Authors: Goetz Eva M. , Ghandi Mahmoud , Treacy Daniel J. , Wagle Nikhil , Garraway Levi A.
Published: March 2023

Supplemental Text. Supplemental Materials and Methods, primer sequences, Supplemental Figure Legends, and references.
Data Supplement from Ubiquitin-like Protein FAT10 Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Modifying β-Catenin Degradation
Authors: Yuan Rongfa , Wang Kai , Hu Junwen , Yan Chen , Li Ming , Yu Xin , Liu Xiuxia , Lei Jun , Guo Wuhua , Wu Linquan , Hong Kui , Shao Jianghua
Published: March 2023

Supplementary Figure S2. An shRNA-resistant FAT10 plasmid rescues the expression of HOXB9 and recovers the cell migration and invasion phenotype in shFAT10 HCC cells.
Supplementary Figure 3 from The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors
Authors: Izumchenko Evgeny , Chang Xiaofei , Michailidi Christina , Kagohara Luciane , Ravi Rajani , Paz Keren , Brait Mariana , Hoque Mohammad O. , Ling Shizhang , Bedi Atul , Sidransky David
Published: March 2023

PDF file - 127KB, Levels of Mig6 protein in the panel of 25 human cancer cell lines with known erlotinib resistance was identified by immunoblot analysis followed by densitometric quantification. The expression level of Mig6 was plotted against IC50 of corresponding cell line.
Supplementary Figure S5 from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
Authors: Kharma Budiman , Baba Tsukasa , Matsumura Noriomi , Kang Hyun Sook , Hamanishi Junzo , Murakami Ryusuke , McConechy Melissa M. , Leung Samuel , Yamaguchi Ken , Hosoe Yuko , Yoshioka Yumiko , Murphy Susan K. , Mandai Masaki , Hunstman David G. , Konishi Ikuo
Published: March 2023

Supplementary Figure S5. Significance of STAT1-MYC activity in tumorigenesis.
Supplemental Materials and Methods from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis
Authors: Wu Pei-Chun , Lu Jeng-Wei , Yang Jer-Yen , Lin I-Hsuan , Ou Da-Liang , Lin Yu-Hsiang , Chou Kuan-Hsien , Huang Wen-Feng , Wang Wan-Ping , Huang Yih-Leh , Hsu Chiun , Lin Liang-In , Lin Yueh-Min , Shen C.-K. James , Tzeng Tsai-Yu
Published: March 2023

revised supporting materials and methods
Supplementary Figures S1-S15 from Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem–like Cells in Head and Neck Squamous Carcinomas
Authors: Sun Shuyang , Liu Suling , Duan Sheng Zhong , Zhang Lei , Zhou Henghua , Hu Yongjie , Zhou Xianghui , Shi Chaoji , Zhou Rong , Zhang Zhiyuan
Published: March 2023

Supplementary Figures S1-S15. Identification and enrichment of CSCs directly from clinical SCCHN samples ; qRT-PCR measurement of the c-Met mRNA level and western blot measurement of c-Met protein in HN-CSC#1 spheres, HN-CSC#2 spheres, and HN-CSC#3 spheres infected with lentiviral nonspecific shRNA (scramble) or c-Met-specific shRNAs ; Knockdown of c-Met inhibited the properties of HN-CSCs ; Dose-dependent effect of conventional chemotherapeutic agents (cisplatin, 5-Fu, and docetaxel) on the viability of tumor cells derived from patient HN-0-22, HN-0-29, or HN-0-46 ; Treatment with c-Met inhibitor PF-2341066 inhibited the formation of HN-CSC#2 spheres and HN-CSC#3 spheres in a dose-dependent manner ; Treatment with c-Met inhibitor SU11274 inhibited the formation of HN-CSC#1 spheres and HN-CSC#2 spheres in a dose-dependent manner ; The combination of c-Met inhibition and docetaxel treatment eliminates CSCs in patient-derived tumor xenografts ; Pharmacologic inhibition of c-Met enhances the therapeutic efficacy of conventional anti-cancer agent 5-Fu ; Western blot analysis shows that no anaplastic lymphoma kinase (ALK) expression was detected in seven SCCHN PDXs including HN-0-22, HN-0-29, and HN-0-46-derived xenografts ; Histologic confirmation of metastasis by H&E staining ; RT2 Profiler PCR Array and further qPCR validation ; Downregulation of FZD8-mediated Wnt/β-catenin signaling is a crucial step for the elimination of HN-CSCs caused by c-Met inhibition ; Quantification of the normalized photon flux, measured at weekly intervals following cells inoculation ; Western blot analyses ; C-Met functionally regulates FZD8 through an ERK/c-Fos cascade in HN-CSCs .
Supplementary Figure 4 from GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
Authors: De Francesco Ernestina Marianna , Pellegrino Michele , Santolla Maria Francesca , Lappano Rosamaria , Ricchio Emilia , Abonante Sergio , Maggiolini Marcello
Published: March 2023

PDF file - 51KB, Supplementary Figure S4: VEGF expression induced by E2 and G-1 in CAFs occurs through HIF-1alpha.
Supplemental Figure 4 from Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
Authors: Cekic Caglar , Linden Joel
Published: March 2023

Supplementary Figure 4. Effects of T cell-selective A2AR deletion on expression of CD69 expression on tumor and spleen lymphocytes.
Supplementary Materials and Methods, Supplementary Figure Legends, and Supplementary Table from Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia
Authors: Schubbert Suzanne , Cardenas Anjelica , Chen Harrison , Garcia Consuelo , Guo Wei , Bradner James , Wu Hong
Published: March 2023

Supplementary Materials and Methods, Supplementary Figure Legends, and Characteristics of primary human pediatric T-ALL samples (Supplementary Table S1).
Figure S4 from Synergy between the NAMPT Inhibitor GMX1777(8) and Pemetrexed in Non–Small Cell Lung Cancer Cells Is Mediated by PARP Activation and Enhanced NAD Consumption
Authors: Chan Manuel , Gravel Michel , Bramoullé Alexandre , Bridon Gaëlle , Avizonis Daina , Shore Gordon C. , Roulston Anne
Published: March 2023

Figure S4. The role of PARP in the synergy between PTX and GMX.
Figure S1 and Figure S2 from Synergy between the NAMPT Inhibitor GMX1777(8) and Pemetrexed in Non–Small Cell Lung Cancer Cells Is Mediated by PARP Activation and Enhanced NAD Consumption
Authors: Chan Manuel , Gravel Michel , Bramoullé Alexandre , Bridon Gaëlle , Avizonis Daina , Shore Gordon C. , Roulston Anne
Published: March 2023

Figure S1 and Figure S2. S1: DUT knockdown sensitizes A549 cells to GMX treatment. S2: NAMPT knockdown sensitizes A549 cells to PTX treatment.
Supplemental Fig. 1 from Pancreatic Cancer–Specific Cell Death Induced In Vivo by Cytoplasmic-Delivered Polyinosine–Polycytidylic Acid
Authors: Bhoopathi Praveen , Quinn Bridget A. , Gui Qin , Shen Xue-Ning , Grossman Steven R. , Das Swadesh K. , Sarkar Devanand , Fisher Paul B. , Emdad Luni
Published: March 2023

Supplemental Fig. 1. [pIC]PEI treatment increases the Sub G1 population in pancreatic cancer cells
Supplementary Figure S4 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: March 2023

Supplementary Figure S4. Archazolid induces 6PF2K3 and aldolase C mRNA levels.
Supplementary Figure S3 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: March 2023

Supplementary Figure S3. Archazolid has no influence on HIF1α mRNA levels in MDA-MB-231 cells.
Supplementary Methods, Figure Legends, Tables 1 - 2 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: March 2023

Supplementary Table 1: Proteins that were identified to be differentially expressed in the cytoplasmic fraction of H460 ÃŽÂ²III-tubulin shRNA expressing NSCLC cells. Supplementary Table 2: Proteins that were identified to be differentially expressed in the nuclear fraction of H460 ÃŽÂ²III-tubulin shRNA expressing NSCLC cells.
Supplementary Figure 7 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: March 2023

A) A graph showing a decrease in ÃŽÂ²III-tubulin mRNA expression in A549 NSCLC cells stably expressing ÃŽÂ²III-tubulin shRNA (pRS/ÃŽÂ²IIISH61) vs. cells stably expressing control shRNA (pRS/CtrlSH27). B) Representative western blot demonstrating potent knockdown of ÃŽÂ²III-tubulin protein expression in A549 NSCLC cells stably expressing ÃŽÂ²III-tubulin shRNA (pRS/ÃŽÂ²IIISH61) vs. cells stably expressing control shRNA (pRS/CtrlSH27). GAPDH was used a protein loading control, n = 3 experiments.
Supplementary Figure S1 from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: March 2023

Supplementary Figure S1. Method for automated quantification of cell aggregation. A, schematic showing the main steps for automated detection and characterization of a cell aggregate: image acquisition, selection of the working image (projection or autofocus), image binarization and segmentation, computation of the desired data. B, cell aggregation is independent of integrin adhesion. Left, area variation measured in untreated (control) conditions (n=10) and in the presence of 0.5 mM RGD peptide (n=9). Right, bright-field images of cells cultured in a standard Petri dish and either treated with 0.5 mM RGD peptide for 2 days or not treated (control). Arrows show the points of cell membrane attachment to the substrate.
Supplementary Materials and Methods from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Materials and Methods. This file contains Supplementary Methods, References, and Figure Legends.
Supplementary Table S2 from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: March 2023

Supplementary Table S2. Dasatinib-regulated pY peptides after QC and storey q-value <0.2 cut off (207, 254 pY peptides in H2286 and HCC366, respectively).
Supplemental Figures 1-7 from Erlotinib Pretreatment Improves Photodynamic Therapy of Non–Small Cell Lung Carcinoma Xenografts via Multiple Mechanisms
Authors: Gallagher-Colombo Shannon M. , Miller Joann , Cengel Keith A. , Putt Mary E. , Vinogradov Sergei A. , Busch Theresa M.
Published: March 2023

Supplemental Figures 1-7. Supplemental Figure 1. Erlotinib does not alter oxygenation of tumors Supplemental Figure 2. Erlotinib increases in vivo tumor cell death at delayed timepoints. Supplemental Figure 3. In vivo imaging of tumor perfusion is well correlated with ex vivo imaging of the excised tumor. Supplemental Figure 4. VEGF levels decrease in A549 tumors with pre-PDT administration of erlotinib Supplemental Figure 5. Western blot analysis Supplemental Figure 6. BPD levels increase Supplemental Figure 7. A single-dose of erlotinib augments PDT-induced cytotoxicity.
Supplementary Figure 3 from Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity
Authors: Browne Ashley , Tookman Laura A. , Ingemarsdotter Carin K. , Bouwman Russell D. , Pirlo Katrina , Wang Yaohe , McNeish Iain A. , Lockley Michelle
Published: March 2023

Female CD1nu/nu mice with intraperitoneal SKOV3ip1 tumours were injected IP with dl922-947 (10^10 particles). E1A immunohistochemistry was performed on all mice (three mice per time point) and E1A expression was scored by a pathologist who was blind to the experimental groups.
Supplementary Tables S1-S10 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: March 2023

Tables of biochemical and viability assays of resistant cell clones, fractional abundance of MPS1 mutants in different human cancer cell lines and refinement statistics of crystal structures of different MPS1 domains.
Supplementary Figures S1-S5 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Authors: Ko Chun-Jung , Huang Cheng-Chung , Lin Hsin-Ying , Juan Chun-Pai , Lan Shao-Wei , Shyu Hsin-Yi , Wu Shang-Ru , Hsiao Pei-Wen , Huang Hsiang-Po , Shun Chia-Tung , Lee Ming-Shyue
Published: March 2023

Supplementary Figures S1-S5. Identification of TMPRSS2 as a mediator of androgen-induced prostate cancer cell invasion (S1); TMPRSS2 induced matriptase activation in prostate cancer cells (S2); TMPRSS2 promoted matriptase activation and the shedding of matriptase and HAI-1 in PCa cells (S3); Examination of the role of TMPRSS2 in the body weights of xenograft mice, the levels of total matriptase, Ki67 and laminin β1 in xenograft tumor tissues (S4); Higher levels of TMPRSS2 expression correlate with higher levels of matriptase activation in human PCa pathological specimens (S5).
supplementary figure 5 from Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia
Authors: Kim Jin-A , Shim Jae-Seung , Lee Ga-Young , Yim Hyeon Woo , Kim Tae-Min , Kim Myungshin , Leem Sun-Hee , Lee Jong-Wook , Min Chang-Ki , Oh Il-Hoan
Published: March 2023

supplementary figure 5: surface phenotypic characterization of primitive subpopulation of MSCs (P-MSCs).
Supplementary Figure 5 from STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
Authors: Lau Jasmine , Ilkhanizadeh Shirin , Wang Susan , Miroshnikova Yekaterina A. , Salvatierra Nicolas A. , Wong Robyn A. , Schmidt Christin , Weaver Valerie M. , Weiss William A. , Persson Anders I.
Published: March 2023

Figure S5: JAK1/2 inhibitors block a transient STAT3 activation following IR in cultured murine proneural HGG cells.
Supplementary Table S2 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Authors: Mudduluru Giridhar , Abba Mohammed , Batliner Jasmin , Patil Nitin , Scharp Maike , Lunavat Taral R. , Leupold Jörg Hendrik , Oleksiuk Olga , Juraeva Dilafruz , Thiele Wilko , Rothley Melanie , Benner Axel , Ben-Neriah Yinon , Sleeman Jonathan , Allgayer Heike
Published: March 2023

Supplementary Table S2. Gene list.
Supplemental Table S3 from Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer
Authors: Du Juan , Cieslak John A. , Welsh Jessemae L. , Sibenaller Zita A. , Allen Bryan G. , Wagner Brett A. , Kalen Amanda L. , Doskey Claire M. , Strother Robert K. , Button Anna M. , Mott Sarah L. , Smith Brian , Tsai Susan , Mezhir James , Goswami Prabhat C. , Spitz Douglas R. , Buettner Garry R. , Cullen Joseph J.
Published: March 2023

Supplemental Table S3. Summary statistics for tumor volume measurements in the mixed linear regression analysis in orthotopic tumor xenografts.
Supplementary Figure S2 from Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis
Authors: Oei Arlene L. , van Leeuwen Caspar M. , ten Cate Rosemarie , Rodermond Hans M. , Buist Marrije R. , Stalpers Lukas J.A. , Crezee Johannes , Kok H. Petra , Medema Jan Paul , Franken Nicolaas A.P.
Published: March 2023

Expression of p53 with western blot in SiHa cells after radiation and E6-siRNA treatment, and p53 and E6 after hyperthermia with immunohistochemistry in patient biopsies and xenograft tumors.
Supplementary Figure S1 from Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth
Authors: Ito-Kureha Taku , Koshikawa Naohiko , Yamamoto Mizuki , Semba Kentaro , Yamaguchi Noritaka , Yamamoto Tadashi , Seiki Motoharu , Inoue Jun-ichiro
Published: March 2023

Supplementary Figure S1. TMOD1 expression is directly regulated by NF-κB activation.
Supplementary Figures 1-5 from Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion
Authors: Razidlo Gina L. , Magnine Christopher , Sletten Arthur C. , Hurley Rachel M. , Almada Luciana L. , Fernandez-Zapico Martin E. , Ji Baoan , McNiven Mark A.
Published: March 2023

Supplementary Figures 1-5. Supplementary Figure 1. Vav1 is expressed in a subset of tumor cell lines. Supplementary Figure 2. Azathioprine does not inhibit migration by pancreatic tumor cells. Supplementary Figure 3. Vav1 is expressed in tumors from a genetic model of pancreatic cancer. Supplementary Figure 4. Azathioprine treatment does not impact tumor size in mouse models of pancreatic cancer. Supplementary Figure 5. Azathioprine reduces cell propagation in a Vav1-independent manner.
Supplementary Figure 1 from Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging
Authors: Bachawal Sunitha V. , Jensen Kristin C. , Wilson Katheryne E. , Tian Lu , Lutz Amelie M. , Willmann Jürgen K.
Published: March 2023

Supplementary Figure 1. Composite IHC scores for B7-H3 vascular staining in whole tissue breast cancer samples.
Supplementary Figures S1-S5 from TUSC4 Functions as a Tumor Suppressor by Regulating BRCA1 Stability
Authors: Peng Yang , Dai Hui , Wang Edward , Lin Curtis Chun-Jen , Mo Wei , Peng Guang , Lin Shiaw-Yih
Published: March 2023

Supplementary Figures S1-S5. NPRL2/TUSC4 up-regulation doesn't correlate with patient survival (S1); Microarray analysis of NPRL2/TUSC4 knockdown cells (S2); The expression of NPRL2/TUSC4-deficient genes are correlated with canonical pathways changes (S3); Histogram of cell cycle distribution for control and NPRL2/TUSC4-deficiency cells (S4); Colony formation assay of NPRL2/TUSC4 overexpression and NPRL2/TUSC4 knockdown cells (S5).