bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factors for therapy failure after incision and drainage alone for perianal abscesses in children
Authors: Ding CaiLin , Chen YaJun , Yan JiaYu , Wang Kai , Tan Sarah Siyin
Published: February 2024

Background

It is well known that recurrent perianal abscesses (PAs) and fistula-in-ano (FIA) are the main causes of therapy failure following incision and drainage (I&D) for PAs. But few studies have focused on the risk factors for therapy failure after I&D for PAs in children. In this study, we retrospectively examine the risk factors for therapy failure after I&D for PAs in children in a pediatric tertiary care institution.

Methods

A retrospective review of all outpatient children with PA treated by I&D at Beijing Children's Hospital between January 2021 and December 2022 was performed. A follow-up was conducted in October 2023. Patients with other predisposing factors for perianal infection, such as inflammatory bowel disease, hematologic tumor, and anorectal surgery, were excluded from this study. Logistic regression yielding odds ratios (ORs) was used to assess the significance of variables for therapy failure.

Results

Of 160 children initially identified, follow-up was available for 146, with a total of 172 treatments. A total of 91% of children were male. The median (interquartile range) age at I&D was 2 (1, 15) months. The median follow-up duration was 20 (14, 25) months. Therapy failure occurred in 25 (15%) treatments performed for the prevention of recurrence of PA and in 35 (20%) treatments for the prevention of development of FIA. In the univariate analysis, a history of PA (P = 0.001), history of I&D (P = 0.014), and multilocal occurrence (P = 0.003) were associated with therapy failure. A sitz bath after I&D (P = 0.016) and regular cleaning of the wound after I&D (P = 0.024) were associated with therapy success. In the multivariate analysis, a history of PA (P = 0.015, OR = 3.374) and multilocal occurrence (P = 0.012, OR = 4.649) were independently associated with therapy failure. Regular cleaning of the wound (P = 0.017, OR = 0.341) and sitz bath (P = 0.001, OR = 0.128) after I&D were independently associated with therapy success.

Conclusions

A history of PA and multilocal occurrence were predictor factors for therapy failure before I&D. Regular cleaning of the wound and sitz bath after I&D were protective factors for therapy success. Therefore, regular cleaning of the wound and sitz bath after I&D should be emphasized in all children with PAs, especially in those with a history of PA and multilocal occurrence.
Moving beyond traditional therapies: the role of nanomedicines in lung cancer
Authors: Zhang Jingjing , Li Yanzhi , Guo Sa , Zhang Weifen , Fang Bing , Wang Shaohui
Published: February 2024

Amidst a global rise in lung cancer occurrences, conventional therapies continue to pose substantial side effects and possess notable toxicities while lacking specificity. Counteracting this, the incorporation of nanomedicines can notably enhance drug delivery at tumor sites, extend a drug’s half-life and mitigate inadvertent toxic and adverse impacts on healthy tissues, substantially influencing lung cancer’s early detection and targeted therapy. Numerous studies signal that while the nano-characteristics of lung cancer nanomedicines play a pivotal role, further interplay with immune, photothermal, and genetic factors exist. This review posits that the progression towards multimodal combination therapies could potentially establish an efficacious platform for multimodal targeted lung cancer treatments. Current nanomedicines split into active and passive targeting. Active therapies focus on a single target, often with unsatisfactory results. Yet, developing combination systems targeting multiple sites could chart new paths in lung cancer therapy. Conversely, low drug delivery rates limit passive therapies. Utilizing the EPR effect to bind specific ligands on nanoparticles to tumor cell receptors might create a new regime combining active-passive targeting, potentially elevating the nanomedicines’ concentration at target sites. This review collates recent advancements through the lens of nanomedicine’s attributes for lung cancer therapeutics, the novel carrier classifications, targeted therapeutic modalities and their mechanisms, proposing that the emergence of multi-target nanocomposite therapeutics, combined active-passive targeting therapies and multimodal combined treatments will pioneer novel approaches and tools for future lung cancer clinical therapies.
Mitochondrial quality control alterations and placenta-related disorders
Authors: Wu Yamei , Li Meng , Ying Hao , Gu Ying , Zhu Yunlong , Gu Yanfang , Huang Lu
Published: February 2024

Mitochondria are ubiquitous in eukaryotic cells. Normal maintenance of function is the premise and basis for various physiological activities. Mitochondrial dysfunction is commonly observed in a wide range of pathological conditions, such as neurodegenerative, metabolic, cardiovascular, and various diseases related to foetal growth and development. The placenta is a highly energy-dependent organ that acts as an intermediary between the mother and foetus and functions to maintain foetal growth and development. Recent studies have demonstrated that mitochondrial dysfunction is associated with placental disorders. Defects in mitochondrial quality control mechanisms may lead to preeclampsia and foetal growth restriction. In this review, we address the quality control mechanisms of mitochondria and the relevant pathologies of mitochondrial dysfunction in placenta-related diseases, such as preeclampsia and foetal growth restriction. This review also investigates the relation between mitochondrial dysfunction and placental disorders.
Current progress in research focused on salt tolerance in Vitis vinifera L.
Authors: Han Yan , Li Xiujie
Published: February 2024

Soil salinization represents an increasingly serious threat to agronomic productivity throughout the world, as rising ion concentrations can interfere with the growth and development of plants, ultimately reducing crop yields and quality. A combination of factors is driving this progressive soil salinization, including natural causes, global climate change, and irrigation practices that are increasing the global saline-alkali land footprint. Salt stress damages plants both by imposing osmotic stress that reduces water availability while also inducing direct sodium- and chlorine-mediated toxicity that harms plant cells.Vitis viniferaL. exhibits relatively high levels of resistance to soil salinization. However, as with other crops, grapevine growth, development, fruit yields, and fruit quality can all be adversely affected by salt stress. Many salt-tolerant grape germplasm resources have been screened in recent years, leading to the identification of many genes associated to salt stress and the characterization of the mechanistic basis for grapevine salt tolerance. These results have also been leveraged to improve grape yields through the growth of more tolerant cultivars and other appropriate cultivation measures. The present review was formulated to provide an overview of recent achievements in the field of research focused on grapevine salt tolerance from the perspectives of germplasm resource identification, the mining of functional genes, the cultivation of salt-tolerant grape varieties, and the selection of appropriate cultivation measures. Together, we hope that this systematic review will offer insight into promising approaches to enhancing grape salt tolerance in the future.
Sex based differences in functional connectivity during a working memory task: an fNIRS study
Authors: Shirzadi Sima , Dadgostar Mehrdad , Einalou Zahra , Erdoğan Sinem Burcu , Akin Ata
Published: February 2024

Differences in corticocerebral structure and function between males and females and their effects on behavior and the prevalence of various neuropsychiatric disorders have been considered as a fundamental topic in various fields of neuroscience. Recent studies on working memory (WM) reported the impact of sex on brain connectivity patterns, which reflect the important role of functional connectivity in the sex topic. Working memory, one of the most important cognitive tasks performed by regions of the PFC, can provide evidence regarding the presence of a difference between males and females. The present study aimed to assess sex differences in brain functional connectivity during working memory-related tasks by using functional near-infrared spectroscopy (fNIRS). In this regard, nine males and nine females completed a dual n-back working memory task with two target inputs of color and location stimuli in three difficulty levels (n = 0, 1, 2). Functional connectivity matrices were extracted for each subject for each memory load level. Females made less errors than males while spending more time performing the task for all workload levels except in 0-back related to the color stimulus, where the reaction time of females was shorter than males. The results of functional connectivity reveal the inverse behavior of two hemispheres at different memory workload levels between males and females. In the left hemisphere, males exhibited stronger connectivity compared to the females, while stronger connectivity was observed in the females' right hemisphere. Furthermore, an inverse trend was detected in the channel pairs with significant connectivity in the right hemisphere of males (falling) and females (rising) by enhancing working memory load level. Considering both behavioral and functional results for two sexes demonstrated a better performance in females due to the more effective use of the brain. The results indicate that sex affects functional connectivity between different areas in both hemispheres of the brain during cognitive tasks of varying difficulty levels although the general impression is that spatial capabilities are considered as a performance of the brain's right hemisphere. These results reinforce the presence of a sex effect in the functional imaging studies of hemodynamic function and emphasize the importance of evaluating brain network connectivity for achieving a better scientific understanding of sex differences.
The effect of students' effort–reward imbalance on learning engagement: the mediating role of learned helplessness and the moderating role of social support
Authors: Liu Shengmin , Wang Yuanru , He Wanning , Chen Yu , Wang Qiangqiang
Published: February 2024

Introduction

To explore the predictive effect of effort–reward imbalance on students' learning engagement and to elucidate the underlying mechanism, 796 students were selected for a survey.

Methods

The participants were required to complete four scales: the Effort-reward Imbalance Scale, the Learning Engagement Scale, the Learned Helplessness Questionnaire, and the Perceived Social Support Scale.

Results

(1) Students' effort–reward imbalance significantly and negatively predicts their learning engagement; (2) Learned helplessness serves as a mediator in the relationship between students' effort–reward imbalance and learning engagement; (3) Social support plays a moderating role in the association between effort–reward imbalance and learned helplessness. High levels of social support can buffer the impact of an effort–reward imbalance on learned helplessness, and the protective effect of social support is more obvious when the effort–reward imbalance is low.

Discussion

The present study revealed how an effort–reward imbalance affects learning engagement among students through the dimensions of learned helplessness and perceived social support. The constructed model not only further clarifies the mechanism underlying the relationship between effort–reward imbalance and learning engagement but also holds significant implications for guiding students' education.
The prevalence of mathematical difficulties among primary school children in Mainland China: a systematic review and meta-analysis
Authors: Wang Yanjiao , Long Jia , Wang Pei
Published: February 2024

The prevalence of mathematical difficulties (MD) among primary school children in China and its related factors remain unclear. To provide a suitable foundation for formulating appropriate screening and intervention strategies, this study aimed to estimate the prevalence of MD and its possible factors among primary school children in China. Articles were identified from seven databases and included if they reported on the prevalence of MD among primary school children in China. A total of 30,881 articles were retrieved, 975 of which were subjected to full evaluation. In total, 54 studies involving 34,815 participants (mean age 9.86 ± 3.13 years) were included. Analyses were conducted using the Meta and Metafor packages in the statistical software environment R. We used meta-regression and subgroup analyses by variable type to evaluate the potential prevalence factors. The pooled prevalence of MD among primary school children in China was 8.97%, whereas the prevalence rates of MD in lower, middle, and upper primary schools were 11.57%, 10.07%, and 4.76%, respectively. The results showed that the prevalence of MD among primary school children in China was significantly related to grade level and the cut-off points selected for screening MD and that the prevalence of MD in middle primary school was higher in girls than in boys. The prevalence of MD in primary schools in China was slightly higher than that in countries such as the United Kingdom and the United States. The prevalence of MD was higher in the lower and middle grades of primary school. The grade level and cut-off points selected during MD screening were closely related to the prevalence of MD. More attention should be paid to girls with MD in middle primary school.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023410311, identifier: CRD42023410311.
Comparative analysis of antibiotic susceptibility patterns and clinical features of mucoid and non-mucoid Pseudomonas aeruginosa infections: a retrospective study
Authors: Luo Maoling , Li Si , Luo Wenying
Published: February 2024

Background

Pseudomonas aeruginosa (PA) is a prevalent opportunistic pathogen that has close associations with both acute and chronic infections. However, there exists an insufficiency of accurate and comprehensive data pertaining to the antimicrobial susceptibility patterns and clinical characteristics of both mucoid and non-mucoid strains of PA (mPA and non-mPA, respectively).

Methods

From January 1, 2021 to December 31, 2022, a thorough retrospective study was carried out to examine and compare the antibiotic susceptibility test outcomes and clinical characteristics of hospitalized patients with mPA and non-mPA infections.

Results

This study investigated a cohort of 111 patients who were diagnosed with mPA infections, as well as 792 patients diagnosed with non-mPA infections. Significant demographic disparities, including gender (p < 0.001), age (p < 0.001), length of hospital stay (p < 0.001), diabetes (p = 0.043), and hypertension (p < 0.001), are evident between the mPA and non-mPA groups. The mPA group commonly necessitates hospitalization for respiratory system diseases, whereas the non-mPA group is associated with concomitant cardiovascular and cerebrovascular diseases. The mPA group demonstrates lower utilization rates of medical devices, such as Foley catheter (p < 0.001), nasogastric tube (p < 0.001), mechanical ventilation (p < 0.001), tracheostomy (p < 0.001), arterial and venous catheterization (p < 0.001), and exhibits superior organ function status, including lower incidences of hypoalbuminemia (p < 0.001), septic shock (p < 0.001), liver dysfunction (p < 0.001), renal failure (p < 0.001), and respiratory failure (p < 0.001). The non-mPA group is more vulnerable to infection with two or more bacterial pathogens compared to the mPA group, with the non-mPA group frequently resulting in Enterobacteriaceae infections and the mPA group being associated with fungal infections. Variations in antibiotic sensitivity are noted for Amikacin (p < 0.001), Ciprofloxacin (p < 0.001), Cefepime (p = 0.003), and Levofloxacin (p < 0.001) in antibiotic susceptibility testing, with resistance patterns closely tied to specific antibiotic usage.

Conclusion

There are significant demographic characteristics, clinical manifestations and antibiotic susceptibility between mPA and non-mPA infections. It is crucial to emphasize these characteristics due to their significant role in preventing and treating PA infections.
Features of adaptive training algorithms for improved complex skill acquisition
Authors: Verniani Alessandro , Galvin Ellery , Tredinnick Sandra , Putman Esther , Vance Eric A. , Clark Torin K. , Anderson Allison P.
Published: February 2024

Training complex skills is typically accomplished by means of a trainer or mediator who tailors instruction to the individual trainee. However, facilitated training is costly and labor intensive, and the use of a mediator is infeasible in remote or extreme environments. Imparting complex skills in applications like long-duration human spaceflight, military field operations, or remote medicine may require automated training algorithms. Virtual reality (VR) is an effective, easily programmable, immersive training medium that has been used widely across fields. However, there remain open questions in the search for the most effective algorithms for guiding automated training progression. This study investigates the effects of responsiveness, personalization, and subtask independence on the efficacy of automated training algorithms in VR for training complex, operationally relevant tasks. Thirty-two subjects (16M/16F, 18–54 years) were trained to pilot and land a spacecraft on Mars within a VR simulation using four different automated training algorithms. Performance was assessed in a physical cockpit mock-up. We found that personalization results in faster skill acquisition on average when compared with a standardized progression built for a median subject (p = 0.0050). The standardized progression may be preferable when consistent results are desired across all subjects. Independence of the difficulty adjustments between subtasks may lead to increased skill acquisition, while lockstep in the progression of each subtask increases self-reported flow experience (p = 0.01), fluency (p = 0.02), and absorption (p = 0.01) on the Flow Short Scale. Data visualization suggests that highly responsive algorithms may lead to faster learning progressions and higher skill acquisition for some subjects. Improving transfer of skills from training to testing may require either high responsiveness or a standardized training progression. Optimizing the design of automated, individually adaptive algorithms around the training needs of a group may be useful to increase skill acquisition for complex operational tasks.
The acute effects of a stretching and conditioning exercise protocol for the lower limbs on gait performance- a proof of concept and single-blind study
Authors: Santinelli Felipe B. , Prieto Silveira-Ciola Aline , Moreno Vinicius C. , Kuroda Marina H. , Barbieri Fabio A.
Published: February 2024

Background

Due to improvement in movement performance, post-activation performance enhancement (PAPE) may open new possibilities to improve gait performance. However, no study has attempted to translate this phenomenon into walking. Therefore, the study aimed to test whether acute stretching followed by a conditioning exercise can improve subsequent gait performance in healthy adults.

Research question

Can an exercise protocol subsequently improve gait performance?

Methods

Sixteen individuals walked four 10-m trials (in each period) before and after 7 min of an exercise protocol composed of stretching (focusing on the lower limb) and a conditioning exercise (standing calf-raise wearing a vest of 20 kg). Gait spatialtemporal parameters and muscle activity of tibialis anterior and gastrocnemius medialis and lateralis muscles were obtained by a 3D-motion system and wireless electromyography, respectively. Before and after the exercise protocol, kinematic and muscle activity parameters were compared by a one-way ANOVA and the Wilcoxon signed-rank test, respectively.

Results

After the exercise protocol, the participants walked with a faster step velocity (p < 0.018) and with a lower step duration (p < 0.025). Also, higher peak muscle activity (p < 0.008) and low-frequency (p < 0.034) activation of the anterior tibial muscle after the exercise protocol were observed.

Significance

In conclusion, the protocol improves the stability and the muscles’ efficiency during gait, contributing to a new approach to enhancing gait rehabilitation programs
Process optimization and identification of antioxidant peptides from enzymatic hydrolysate of bovine bone extract, a potential source in cultured meat
Authors: Begum Nabila , Khan Qudrat Ullah , Al-Dalali Sam , Lu Daoqiang , Yang Fang , Li Jie , Wu Di , Li Riwang , Wang Jun , Liu Dahai , Song Huanlu
Published: February 2024

Bone protein is a significant secondary product of the meat industry, comprising a substantial quantity of protein. These proteins could be broken down through enzymatic hydrolysis to generate antioxidant peptides. This study aimed to produce antioxidant peptides from bovine bone extract by enzymatic hydrolysis utilizing Flavourzyme and Protamex by optimizing enzyme amounts and time using the Box–Behnken design. The final optimized conditions obtained through the model were as follows: The amount of Flavourzyme was 1,100 U, the amount of Protamex was 2,814 U, and the time was 3.77 (h). Bovine bone extract hydrolysate (BBEH) was purified stepwise using ultrafiltration membranes with molecular cutoffs of 5, 3, and 1 kDa. To assess the antioxidant capacity of the fractions, several methods were used, including radical scavenging activity “1,1-diphenyl-2-picrylhydrazyl (DPPH),” “2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS),” metal chelating activity (MCA), reducing power (RP), and thiobarbituric acid assay (TBA). The results indicated that the ultrafiltration fraction with a molecular weight of less than 1 kDa showed significant antioxidant activity, with 48, 42, and 50% inhibition rates for DPPH, ABTS, and metal chelating, respectively. Using size exclusion chromatography, the fraction with a molecular weight less than 1 kDa was further separated into five sub-fractions: Frac-I, Frac-II, Frac-III, Frac-IV, and Frac-V. Sub-Frac-III, which exhibits significant DPPH radical scavenging activity (55%) and a reducing power of 0.8 at 700 nm, was separated into six sub-sub-fractions using reversed-phase HPLC (RP-HPLC) based on molecular weight and hydrophobicity. The sub-sub-fraction with the highest value for DPPH radical scavenging activity was sub-Fra-III-6, which exhibited approximately 69.45% activity. The sub-Fra-III-6 was analyzed using LC–MS/MS, which identified two specific peptides: Ala-Pro-Phe with a mass of 333.12 Da and Asp-His-Val with a mass of 369.14 Da. These two peptides are likely the primary peptides that might have a crucial role in antioxidant capacity. It can be concluded that BBEH is a valuable source of natural antioxidants and has the potential to serve as a viable resource in the cultured meat industry.
A highly pathogenic avian influenza virus H5N1 clade 2.3.4.4 detected in Samara Oblast, Russian Federation
Authors: Glazunova Anastasia , Krasnova Elena , Bespalova Tatiana , Sevskikh Timofey , Lunina Daria , Titov Ilya , Sindryakova Irina , Blokhin Andrey
Published: February 2024

Avian influenza (AI) is a global problem impacting birds and mammals, causing economic losses in commercial poultry farms and backyard settings. In 2022, over 8,500 AI cases were reported worldwide, with the H5 subtype being responsible for many outbreaks in wild and domestic birds. In the territory of the Russian Federation, outbreaks of AI have been massively reported since 2020, both among domestic bird species and wild bird species. Wild migratory birds often serve as natural reservoirs for AI viruses, and interactions between bird species can lead to the emergence of new, highly pathogenic variants through genetic recombination between strains. In order to combat the widespread outbreaks of the disease and potential risks of further spread in 2021, monitoring studies were conducted in the Samara Oblast, the southeastern region of European Russian Federation. These studies aimed to diagnose and characterize circulating AI virus variants among wild migratory birds during waterfowl hunting in areas of mass nesting. Among the 98 shot birds, a highly pathogenic A/H5N1 AI virus was detected in a Eurasian Teal from the Bolshechernigovsky district. It was classified into clade 2.3.4.4 based on the cleavage site structure of HA. Phylogenetic analysis showed a high relatedness of the identified strain in the Samara Oblast with field isolates from Russia, Nigeria, Bangladesh, and Benin. The article emphasizes the importance of monitoring AI virus spread in both wild and poultry, highlighting the need for timely information exchange to assess risks. Further comprehensive studies are necessary to understand virus dissemination pathways.
Determining the nutritional values of new corn varieties on pigs and broilers
Authors: Cao Hongrui , Yan Lei , Song Xiaoming , Liu Ling , Xu Shaohua , Hu Shengdi , Zhang Shuai
Published: February 2024

The objective of this study was to evaluate the nutritional values of three new corn varieties (high-iron corn, cadmium-resistant corn, low-phytate phosphorus corn) cultivated with molecular marker-assisted selection breeding technique fed to growing pigs and broilers. Exp. 1 was conducted to compare the nutritional values of high-iron corn, high-chromium corn, low-phytate phosphorus corn and conventional corn fed to growing pigs based on a 15 × 2 Youden square design. Exp.2 was conducted to compare the nutritional values of high-iron corn, low-phytate phosphorus corn and conventional corn fed to broilers based on a completely randomized design. Parameters including nutrient digestibility, available energy and amino acids, and mineral deposition were measured. The results shows that the iron content in the high-iron corn and the cadmium content in the cadmium-resistant corn were 29.608 mg/kg and 0.0057 mg/kg, respectively, both were greater than those in the other three kinds of corns. When fed to growing pigs, the neutral detergent fiber digestibility of the high-iron corn group was lower than that of the conventional corn group (p < 0.05), and the acid detergent fiber digestibility of the high-iron group and the low-phytate phosphorus corn group was lower than that of the conventional corn group (p < 0.01). In addition, the digestible energy value of the high-iron corn in growing pigs was lower than that of the conventional corn (p < 0.05). When fed to broilers, it was observed that the tibia length of the low-phytate phosphorus corn group and the high-iron corn group was lower than that of the conventional corn group (p < 0.05). Moreover, the iron emission in feces of broilers fed the low-phytate phosphorus corn was lower than those fed the conventional corn and the high-iron corn (p < 0.05). In conclusion, modern breeding techniques could provide new plant ingredients which have potential benefits to pig and broiler production, but the comprehensive effects may be better when applied to growing pigs considering growth performance and environment effects. The breeding techniques related to the current study rarely changed the available energy values of the corn in growing pigs and broilers.
The Effect of Nitrogen Reduction and Applying Bio-Organic Fertilisers on Soil Nutrients and Apple Fruit Quality and Yield
Authors: Yao Ruiyun , Bai Ru , Yu Qingfan , Bao Yaqi , Yang Weiwei
Published: February 2024

In this study, we investigated the effect of partially substituting inorganic nitrogen with bio-organic fertiliser on the ‘Tianhong2’ Fuji apple planting in Xinjiang. Bio-organic fertiliser was applied, and nitrogen was reduced by 20% (T2), 40% (T3), and 60% (T4) during the blooming and fruit expansion periods with conventionally fertilised fields used as control (T1); soil nutrient, soil enzyme activity, leaf nutrients, fruit quality, and yield were measured. The total nitrogen (TN), total phosphorus (TP), total potassium (TK), total calcium (TCa), available phosphorus (AP), available potassium (AK), and soil organic matter (SOM) contents, as well as the soil catalase (S-CAT), soil uretrase (S-UE), soil saccharase (S-SC), and soil nitrate reductase (S-NR) activities, significantly increased in the experimental soils compared with those in T1. In addition, TP, TCa, and total magnesium (TMg) content in apples significantly increased. Compared to T1, the T2 and T3 treatments significantly improved the fruit yield and quality, increasing the sugar–acid ratio, soluble protein, soluble sugar, peel carotenoid, and anthocyanin content and reducing peel chlorophyll content. The brightness (L*), red–green axis (a*), yellow–blue axis (b*), colour intensity (C), and tone (h°) values changed. The yield per hectare and nitrogen fertiliser partial productivity values were significantly increased. Overall, the T2 treatment resulted in the best outcome for the Yili area. In conclusion, partially substituting inorganic nitrogen with bio-organic fertiliser can effectively increase soil and leaf nutrient content and improve fruit yield and quality.
Feeding Postures and Substrate Use of François’ Langurs (Trachypithecus francoisi) in the Limestone Forest of Southwest China
Authors: Lu Shiyi , Lin Nanxin , Huang Anshu , Tong Dewen , Liang Yongyan , Li Youbang , Lu Changhu
Published: February 2024

The feeding posture of a group of François’ langurs in Fusui County, Guangxi, was studied using instantaneous scan sampling from January to December 2016 to explore how the species adapts to karst limestone forests by collecting data on feeding posture, forest strata height, and substrate use. The results showed that leaves were the main food type of the François’ langurs, with young leaves accounting for 64.97% ± 19.08% of the food composition, mature leaves accounting for 11.88% ± 12.09%, fruits accounting for 12.96% ± 12.89%, flowers accounting for 4.16% ± 4.06%, and other food types, including stems, petioles, and other unknown parts of the tree, accounting for a total of 6.03% ± 9.09%. The François’ langurs had four main postures during feeding, of which sitting and bipedal standing feeding accounted for the largest proportions, at 85.99% ± 5.97% and 12.33% ± 6.08% of the total records, respectively. Quadrupedal standing and suspending were rarely observed and only appeared occasionally during feeding activities at the peak resting period, the two postures together accounting for 1.39% ± 1.59% of the total records. The feeding postures of the langurs had marked seasonal variation, as evidenced by the fact that seated feeding accounted for a significantly higher proportion of the total behavioral records in the rainy season than in the dry season, whereas feeding while standing bipedally was significantly more frequent during the dry season. Correlation analyses showed that feeding posture was correlated with food composition, showing a positive correlation between the proportion of bipedal standing feeding and mature leaf consumption. François’ langurs preferred to forage in the lower and middle forest layers, with the lower forest layer accounting for 55.93% ± 16.50% of the total number of recordings and the middle forest layer accounting for 33.63% ± 18.33%. Langurs were less likely to forage on the ground (rocks), accounting for only 6.79% ± 4.78% of the records. The frequency of langurs feeding in the upper part of the forest layer was the lowest at 3.65% ± 2.73%. Additionally, in the dry season, langurs utilized the lower forest layer more but used the middle forest layer less than in the rainy season. This study demonstrates that the spatial distribution of foods in the limestone forest has an important effect on the feeding posture of François’ langurs and their forest layer utilization.
Optimal Design of Tilted Building Envelope Considering Air Conditioning Energy Demand, Daylight Utilization and Glare Protection—Case Study
Authors: Fang Aimin , Yang Yi , Dong Wenqiang
Published: February 2024

An important energy-saving method to optimize building envelope design is the integration of local climate characteristics. This study attempts to find sloped facade configurations to balance air conditioning energy demand and daylight utilization for four directions in an area with a hot climate. Tilt angle dependence of the air conditioning energy demand, useful daylight illuminance (UDI) and daylight glare index (DGI) are selected to investigate the acceptance thresholds of the tilt angle. The final facade’s configuration is achieved by employing the graphical optimization method. An acceptable solution that balances better daylight performance and less energy consumption by air conditioning is developed. Due to the considered city being located in a low-latitude area with great daylight availability as well as a fully dimmable light control strategy, unbearable glare reduction can be achieved by benefiting from the sloped facades, without necessarily sacrificing much usable daylight. Meanwhile, there is no obvious increase in the demand for lighting energy consumption, and a good outward view is preserved. The sloped rather than vertical facade provides natural solar shading to the east-, south- and west-oriented windows while allowing low-angle winter solar heat to warm the building space. Tilt angles between 35°and 40° are preferred for the east facade, and smaller tilt angles of between 30°and 35° are recommended for the south facade. Larger tilt angles of between 40°and 45° are preferred for the west facade. However, the north-facing facade’s outward tilt would cause an undesirable increase in air conditioning energy demand. The annual air conditioning energy demand of the east-, south- and west-facing space is found to separately decrease by 7.1%, 7.3% and 9.9%, respectively, benefiting from the sloped facades.
Mechanical Behaviors and Structure Safety of a Tunnel Crossing a Water-Rich Fault Fracture Zone—A Case Study
Authors: Chen Linjie , Deng Yuan , Yang Biao , Wang Siqi , Li Huayun , Tan Yinjun
Published: February 2024

To study the potential disasters caused by tunnels crossing water-abundant fault areas, this study takes the Jinyunshan Tunnel as an example, and studies the groundwater flow law between different rock layers, the interaction between surrounding rock hydrostatic pressure and soil pressure, and the mechanical features and safety of the lining during construction by combining field tests and finite element simulation analysis. The results show that the displacement change rate of the tunnel vault reaches 2.8 mm/d, and the maximum earth pressure and hydrostatic pressure are 2.3 MPa and 1.15 MPa, respectively, both at the bottom of the tunnel in section II. When the tunnel enters the fault fracture zone from the V surrounding rock, the bending moment of the lining increases by 222.78% at the left haunch and 60.87% at the bottom of the right wall. The axial force of the right spandrel increases by 2579.2%, and the left spandrel increases by 221.18%. The safety factor of the two sections is greater than 2.4, indicating that the overall structure is in a safe state, but the safety factor of the second right shoulder is 2.54, which is close to the safety threshold of 2.4. The research results provide a basis for the safety design and construction safety of tunnels through water-rich sections in similar fault fracture zones, and provide a reference for reducing groundwater loss and protecting ecological vegetation.
Role of Nutraceuticals in Counteracting Inflammation in In Vitro Macrophages Obtained from Childhood Cancer Survivors
Authors: Di Paola Alessandra , Marrapodi Maria Maddalena , Pota Elvira , Colucci Cante Rosa , Rana Deeksha , Giliberti Giulia , Di Feo Giuseppe , Ahmed Shakeel , Roberti Domenico , Nigro Roberto , Rossi Francesca , Argenziano Maura
Published: February 2024

The advancement of anti-cancer therapies has markedly improved the survival rate of children with cancer, making them long-term childhood cancer survivors (CCS). Nevertheless, these treatments cause a low-grade inflammatory state, determining inflamm-aging and, thus, favoring the early onset of chronic diseases normally associated with old age. Identification of novel and safer therapeutic strategies is needed to counteract and prevent inflamm-aging. Macrophages are cells involved in immune and inflammatory responses, with a pivotal role in iron metabolism, which is related to inflammation. We obtained macrophages from CCS patients and evaluated their phenotype markers, inflammatory states, and iron metabolism by Western blotting, ELISA, and iron assays. We observed a strong increase in classically activated phenotype markers (M1) and iron metabolism alteration in CCS, with an increase in intracellular iron concentration and inflammatory markers. These results suggest that the prevalence of M1 macrophages and alteration of iron metabolism could be involved in the worsening of inflammation in CCS. Therefore, we propose macrophages and iron metabolism as novel therapeutic targets to counteract inflamm-aging. To avoid toxic regimens, we tested some nutraceuticals (resveratrol, curcumin, and oil-enriched lycopene), which are already known to exert anti-inflammatory properties. After their administration, we observed a macrophage switch towards the anti-inflammatory phenotype M2, as well as reductions in pro-inflammatory cytokines and the intracellular iron concentration. Therefore, we suggest—for the first time—that nutraceuticals reduce inflammation in CCS macrophages through a novel anti-inflammatory mechanism of action, modulating iron metabolism.
Treatment Strategies Guided by [18F]FDG-PET/CT in Patients with Locally Advanced Cervical Cancer and [18F]FDG-Positive Lymph Nodes
Authors: Olthof Ester P. , Wenzel Hans H. B. , van der Velden Jacobus , Stalpers Lukas J. A. , Mom Constantijne H. , van der Aa Maaike A.
Published: February 2024

Background: Modern treatment guidelines for women with advanced cervical cancer recommend staging using 2-deoxy-2-[18F]fluoro-D-glucose positron emission computed tomography ([18F]FDG-PET/CT). However, the risk of false-positive nodes and therapy-related adverse events requires caution in treatment planning. Using data from the Netherlands Cancer Registry (NCR), we estimated the impact of [18F]FDG-PET/CT on treatment management in women with locally advanced cervical cancer, i.e., on nodal boosting, field extension, and/or debulking in cases of suspected lymph nodes. Methods: Women diagnosed between 2009 and 2017, who received chemoradiotherapy for International Federation of Gynaecology and Obstetrics (2009) stage IB2, IIA2-IVB cervical cancer with an [18F]FDG-positive node, were retrospectively selected from the NCR database. Patients with pathological nodal examination before treatment were excluded. The frequency of nodal boosting, extended-field radiotherapy, and debulking procedures applied to patients with [18F]FDG-positive lymph nodes was evaluated. Results: Among the 434 eligible patients with [18F]FDG-positive nodes, 380 (88%) received interventions targeting these lymph nodes: 84% of these 380 patients received nodal boosting, 78% extended-field radiotherapy, and 12% debulking surgery. [18F]FDG-positive nodes in patients receiving these treatments were more likely to be classified as suspicious than inconclusive (p = 0.009), located in the para-aortic region (p < 0.001), and larger (p < 0.001) than in patients who did not receive these treatments. Conclusion: While existing guidelines advocate [18F]FDG-PET/CT-guided treatment planning for the management of advanced cervical cancer, this study highlights that not all cases of [18F]FDG-positive nodes received an intervention, possibly due to the risk of false-positive results. Improvement of nodal staging may reduce suboptimal treatment planning.
Hydrogen Storage in Porous Rocks: A Bibliometric Analysis of Research Trends
Authors: Uliasz-Misiak Barbara , Misiak Jacek , Lewandowska-Śmierzchalska Joanna
Published: February 2024

Currently, there is an increasing number of research studies on underground storage of hydrogen in porous rocks (aquifers and depleted hydrocarbon fields). An important aspect of this process is the efficiency of hydrogen storage, which is defined as the correct operation of a storage facility (the ability to inject and withdraw an appropriate quantity of gas) and the safety of storage, which is influenced by numerous factors, including geological factors. With an increasing number of publications, gathering knowledge and keeping track of scientific progress is becoming increasingly complex. In addition to the technical interdependence of the parameters analysed, there are also interrelationships between scientific publications addressing issues related to underground hydrogen storage in porous rocks. The aim of this paper is to analyse the literature on hydrogen storage efficiency in porous rocks and, on the basis of the analysis, to identify the most important research trends and issues relevant to their implementation. This article presents an analysis of publications indexed in the SCOPUS database. The analysis included publications that contained expressions related to the relevant search phrases in their title, abstract or keywords. The dynamics of changes in the interest of researchers on the problem of hydrogen storage in porous rocks and the distribution of studies by geographical location (countries) are presented. Based on an analysis of the number of citations, the most influential publications were identified. Using the VOSviewer version 1.6.19 software, clusters reflecting research sub-areas were identified based on co-occurrence analysis, such as geological and reservoir aspects, reservoir engineering aspects, hydrogeological aspects and petrophysical aspects. Bibliometric methods have great potential for performing quantitative confirmation of subjectively delineated research fields and/or examining unexplored areas. The literature on underground hydrogen storage in porous rocks has been growing rapidly since at least 2018, with researchers conducting their studies in four major research streams: geological and reservoir aspects, reservoir engineering aspects, hydrogeological aspects and petrophysical aspects.
Determination of Particle Size Distribution: Comparison of Standard Hydrometer Method and Laser Diffraction Analysis for Use in Forestry
Authors: Sedláčková Kateřina , Ševelová Lenka , Igaz Dušan , Aydın Elena
Published: February 2024

Laser diffraction analysis is an alternative to standard sedimentation methods designed to determine particle size distribution. In this article, five samples from the forested part of the floodplain of the Svitava River in the Czech Republic were analyzed. Laser diffraction analysis and sedimentation hydrometer method were performed for each sample. The samples were divided according to soil classification into two groups depending on their classification–group A and group B. The results of laser diffraction analysis and hydrometer method were compared. Correlation relationships between both methods were established, and values were recalculated from laser diffraction analysis to the hydrometer method according to correlation equations. The article is a part of the methodology under preparation, which will include the most common soil types in the Czech Republic. This methodology focuses on the use of laser diffraction for the establishment of structures in forest environments using the regional specific standards for particle size distribution determination.
Landsenses in Green Spaces
Authors: Liu Jiang , Wang Xinhao , Hong Xinchen
Published: February 2024

Green spaces, serving as crucial ecological infrastructure, offer numerous ecological system services and enhance human well-being, particularly in densely built environments [...]
The Knowledge and Application of Sedimentary Conditions of Shallow Marine and Tidal Waters of Ionian Islands, Greece: Implications for Therapeutic Use
Authors: Botziolis Chrysanthos , Bourli Nicolina , Zoumpouli Elena , Papadopoulou Penelope , Dimopoulos Nikolaos , Kovani Andriana , Zelilidis Panagiotis , Aspioti Diamantina Christina , Iliopoulos George , Zelilidis Avraam
Published: February 2024

This study delves into the sedimentation mechanisms governing mud deposits in shallow marine and tidal environments, with a particular focus on elucidating the versatile therapeutic applications of these muds. This research provides valuable insights for optimizing the selection of mud as a cosmetic resource that can positively influence human health and well-being by utilizing a comprehensive analysis involving CaCO3, TOC, grain size, and statistical parameters across six outcrops situated on the Kefalonia and Corfu islands. The research reveals that the CaCO3 content of mud deposits on both islands is comparable. Despite the average value (26.71%) significantly exceeding the recommended value (10%) for optimal plasticity, no discernible impact on the mechanical behavior and plasticity of the clay was observed, rendering it a neutral quality criterion. Notably, the TOC content is higher on Corfu Island, suggesting its potential superiority for mud therapy. However, all samples exhibit a TOC content (<0.77%) considerably below the threshold required (2–5%) for material maturation in mud therapy. Consequently, an enrichment of samples with organic matter is imperative. The application of statistical parameters, analyzed through graphical methods, facilitated the creation of various bivariate diagrams, offering insights into the prevailing environmental conditions during deposition. Linear and multigroup discriminant analyses categorize two sediment types: a unimodal type, characterized by mud grain-size dominance, deposited in a shallow water environment, and a bi-modal type, featuring mud and sand content, deposited in a tidal-affected environment. This classification underscores the potential of shallow marine muds (Kefalonia Island) for therapeutic use, given their optimal grain size. In contrast, the tidal mud (Corfu Island), while also suitable for mud therapy, necessitates processing as a cosmetic product to minimize sand content, as coarser fractions may induce skin irritations or injuries.
Job Satisfaction within the Grassroots Healthcare System in Vietnam’s Key Industrial Region—Binh Duong Province: Validating the Vietnamese Version of the Minnesota Satisfaction Questionnaire Scale
Authors: Huynh Chin Minh , Nguyen Chuong Hong , Le Khoa Nguyen Dang , Tran Phuong Thi Ngoc , Nguyen Phuong Minh
Published: February 2024

Background: The grassroots healthcare system is the closest and most community-oriented force, working as an extended arm of the primary healthcare network to implement healthcare programs at the household level. Its comprehensive development is a crucial task set by the Vietnamese government. Job satisfaction significantly influences the performance of healthcare staff within this system. Objective: to assess job satisfaction among healthcare staff using the short-form of the Minnesota Satisfaction Questionnaire while also evaluating the Vietnamese translation of this scale. Methods: A descriptive cross-sectional study with analysis based on the responses of 587 healthcare staff using the Vietnamese-translated version of the MSQ short-form scale. The response data from the participants were subjected to CFA, and if the proposed CFA model did not fit the data, EFA was conducted. Results: The results indicate that the new model, which evaluates job-related factors in three distinct groups, is more suitable than the original model. The 14 questions of the MSQ scale were analyzed and categorized into Autonomy, Obligation, and Specificity based on the participants’ responses. The confirmatory factor analysis (CFA) conducted on the new model demonstrated favorable fit indices: CFI = 0.934, TLI = 0.917, GFI = 0.919, and RMSEA = 0.093 (90% CI: 0.085–0.102). Conclusions: The Vietnamese version of the MSQ short form demonstrates reliability and validity. It also provides additional data on the effectiveness of the MSQ short form in measuring job satisfaction.