bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARATIVE ANALYSIS OF THE EFFECTIVENESS OF 4MAT TEACHING METHOD IN REMOVING PUPILS’ PHYSICS MISCONCEPTIONS OF ELECTRICITY
Authors: Ergin Serap , Atasoy Şengül
Published: January 2022

The purpose of this study is to determine pupils’ misconceptions about the electricity and the effects of 4MAT teaching method on these misconceptions. For this purpose, a non-equivalent pretest-posttest control group design was adopted and a three tier test with a sample of 100 ninth grade pupils was used to detect pupils’ misconceptions about the electricity. The analysis of the data showed that pupils have the following misconceptions; local reasoning, attenuation model, empirical rule model, shared current model, current-potential difference confusion, short circuit misconception, current flow as water flow, power supply as a constant current source model and sequential reasoning etc. It was determined that the frequency of most of the misconceptions decreased after the application of the innovation. A greater fall was observed in the experimental group which suggests that the 4MAT teaching method was more effective than the traditional method in reducing misconceptions. Based on the results of this study, investigation of the effects of 4MAT teaching method on other complicated subjects of physics such as magnetism, regular circular momentum is suggested for further studies.
Key words: electricity, 4MAT teaching method, misconceptions, ninth grade pupils, physics teaching.
A COMPARISON OF STUDENTS’ PERFORMANCE, SKILL AND CONFIDENCE WITH PEER INSTRUCTION AND FORMAL EDUCATION
Authors: Gok Tolga
Published: January 2022

The effects of peer instruction (PI) and formal education (FE) on students’ performance, skill, and confidence were investigated. The research was performed in a two-year college classroom with 98 students from two groups enrolled in a physics course. One of the groups was selected as an experimental group, and the other was the control group. The students in the experimental group were instructed by peer instruction with problem solving strategy steps (PSSS), whereas the students in the control group were instructed by formal education including PSSS. The research data were collected with the Physics Achievement Test (PAT) and the Problem Solving Confidence Questionnaire (PSCQ). The problem solving skills of the students in both groups were evaluated using quantitative problems in Newtonian mechanics. The PAT and the PSCQ results related to the performance and confidence of the students indicated that there was a statistically significant difference between the means of the experimental group and the control group in favor of the experimental group. The combination of PI with PSSS was more effective for increasing the problem solving skills of the students than the combination of FE with PSSS.
Key words: formal education, peer instruction, problem solving strategy steps.
DIDACTIC ANALYSIS OF THE WEB ACID-BASE TITRATION SIMULATIONS APPLIED IN PRE-GRADUATE CHEMISTRY TEACHERS EDUCATION
Authors: Machková Veronika , Bílek Martin
Published: January 2022

The wide development of the information and communication technologies provides conditions for using various digital learning objects in education. In Chemistry learning and teaching computer simulations are used for increasing clearness in Chemistry lessons and for supporting experimental activities in laboratory work. For this analysis the topic of acid-base titration was chosen. The research sample included educational simulations of acid-base titration available free on the Internet. In total 35 educational simulations of acid-base titration were found and used for didactic analysis with following research questions: What can be learned from educational simulations of acid-base titration? and How can didactic analysis of different kinds of simulation help to teacher and learner? In the research results of didactic analysis of 35 examples of acid-base titration simulators are presented. Resulting from the analysis we find three different types of educational simulations of acid-base titration with a specific use in Chemistry lessons: (1) simulations of experiments; (2) generators of titration curves according to the user’s choice; (3) presentations of one titration. The summary of all analysed simulations and proposals of their educational applications is available from the web site http://titrace.wz.cz.
Key words: acid-base titration, chemistry instruction, didactic analysis, educational simulation.
Study of Zinc and Manganese content in blood serum, feathers and claws in 14-, 21- and 28-days old broiler chickens with perosis
Authors: Sakara V. , Melnyk A. , Bogatko L. , Bilyk B.
Published: January 2022

Culling due to poor condition, weight loss, mortalityand, as a result, economic losses due to perosa, accordingto various estimates, 1-5% of the group of birds. Due to thedysfunction of the limbs, the bird can suffer from a numberof diseases. Lack of essential nutrients play an important rolein the development of perosis in poultry. Often in farms dueto cost savings, reduce the cost of feed for broilers, which inturn can lead to metabolic disorders in poultry. Therefore, thediagnosis of these disorders requires new approaches. Modernscience is increasingly inclined to non-invasive diagnosis ofmetabolic pathologies. In human medicine, nails and hair areused to study persistent micronutrient deficiencies. And inveterinary medicine in the study of micronutrient deficienciesas a method of non-invasive diagnosis using animal hair.According to the results of our research, theconcentrations of microelements (Zn, Mn) in the feathers of14, 21 and 28-days-old clinically healthy and feathery broilerchickens were determined. On day 14 of the disease, theconcentration of Zinc and Manganese in broiler chickens withperosis was 65.6 ± 2.73 and 17.4 ± 0.79 μg / g, which wasprobably higher than in clinically healthy birds 46.5 ± 1.57(p <0.001) and 10.9 ± 0.80 (p <0.001) μg / g. Analyzing the indicators of micronutrients in the clawsof patients with feathers of broiler chickens of 28 days ofage, the content of Manganese was 10.2 ± 0.51 μg / g, whichis probably less than in clinically healthy birds 15.7 ± 0.97μg / g (p < 0.01). The concentration of zinc in the claws ofhealthy birds is 127.6 ± 3.65 μg / g, which tended to increasecompared to that in healthy birds - 98.3 ± 5.40 μg / g.The results of the analysis show that in birds with signs ofperosis, Zinc and Manganese accumulate in higher concentrations in the feathers compared to clinically healthy chickens. Inturn, the concentration of these elements in the claws in chickens with feathers relative to healthy birds of the group decreases.
Key words: trace elements, non-invasive diagnostics,metabolic pathologies, avian.
Influence of non-ionizing radiation on protein metabolism in chickens
Authors: Prosyanyi S. , Horiuk V.
Published: January 2022

In practical terms, the idea of using an artificial magnetic field is of particular interest, which corresponds in its physical characteristics to the geomagnetic field of the Earth to combat the negative effects of hypogeomagnetic field. Further development of this idea is associated with the use and selection of hypo-, hypermagnetic fields acting on the body with experimental pathology. In this regard, the issue of influence of different duration of irradiation with an alternating pulsed electromagnetic field of ultra-low frequency (APEMF ULF) on the indicators that characterize metabolic processes in the body is insufficiently clarified. Therefore, the aim of research has been to study the effect of alternating pulsed electromagnetic field of ultra-low frequency on protein content and protein metabolism in the body of experimental chickens of the Dominant D959 cross. For this purpose, four experimental and control groups of 120-day-old chickens have been formed – 20 heads in each. The poultry has been kept in a specially equipped room with an alternating pulsed electromagnetic field of ultra-low frequency. The total protein content has been determined by the biuret method; protein fractions (albumins, globulins: alpha-1, alpha-2, beta, gamma) – by diffuse polyacrylamide gel (PAAG) electrophoresis; the content of creatinine, urea and uric acid has been performed by spectrophotometry using standard techniques. According to the results of research, it has been established that by selecting different regimens and duration of action of APEMF ULF, it is possible to influence protein metabolism in the body of chickens. Thus, on the 80th day of continuous irradiation of experimental chickens with APEMF ULF, regardless of the level of protein in the diet, in their blood revealed an increase in total protein, the relative content of globulin fraction mainly due to γ-globulins, and an increase in creatinine, urea and uric acids. When the period of continuous irradiation has been increased to 5 months, a negative effect on protein metabolism has been revealed, which has been manifested by a decrease in total protein content, relative albumin content, decrease in creatinine, urea and uric acid in the serum of experimental chickens. The combination of long-term (for 150 days) daily 60 minutes with weekly intervals of irradiation of chickens with APEMF ULF and their feeding with a 15% increase in protein levels in the diet caused a stimulating effect on protein metabolism and resistance of experimental chickens, with increasing, the relative content of globulins due to the γ-globulin fraction, as well as the main indicators of protein metabolism – creatinine, urea, uric acid.
Key words: electromagnetic influence, chicken of Dominant D959 cross, total protein, protein fractions, creatinine, urea, uric acid.
Climatic stress in pregnant sows: adaptive responses and effects on productivity
Authors: Poroshinska O. , Shmayun S. , Stovbetska L. , Yemelyanenko A. , Nishemenko N. , Koziy V.
Published: January 2022

The article presents data from the scientific literaturedescribing the influence of microclimate parameters on thebody of sows and their offspring. The key factors of thenormal course of physiological processes in the body of sowsand piglets are the optimal temperature, light, air velocity andhumidity. Sensitivity of sows to climatic factors increasessignificantly during pregnancy and lactation. At elevatedoutdoor temperatures, heat stress develops, which negativelyaffects well-being and productivity of sows and significantlyharms the offspring due to intrauterine temperature load. Itis established that there are differences in genetic tolerance to high temperature between different breeds of sows.Changes in physiological and behavioral parameters can beobserved at different stages of the reproductive cycle of sows.Pregnant sows respond to heat stress by increasing rectal andskin temperature, respiration rate and reducing their overallactivity. Elevated ambient temperature during late pregnancyincreases the catabolism of lipids and proteins in the bodyof sows, the concentration of adrenocorticotropic hormone,cortisol in the blood increases. Heat-exposed sows also havea shorter gestation period and a lower nest weight of pigletsat birth. During lactation, there are changes in general andfeed behavior, reduced feed intake and as a result, the processof milk production is disrupted. In particular, it was foundthat with increasing temperature from 20.0 to 29.0 °C milkproduction in sows decreases from 10.43 to 7.35 kg/day(p <0.05). The content of immunoglobulins, vitamins andmicroelements in milk decreases. This leads to a violation ofimportant physiological functions of the body of piglets andhas a negative impact on their growth and development. Themost critical periods for sows are the end of summer and thebeginning of autumn, when anestrus is observed, the rates offertilization, farrowing, fertility and weight gain of piglets arereduced. This is due to an imbalance in the hypothalamicpituitary-adrenal system and high levels of melatonin in theblood. The use of physiological and behavioral indicatorsis necessary to prevent climatic stress and increase animalproductivity.
Key words: physiology, pigs, stress factors, thermoregulation, behavior, reproductive system, pregnancy, lactation.
Dynamics of heart rate variability and the state of endogenous in toxication under different anesthesia regimens in dogs with visceral and somatic types of pain reaction
Authors: Rublenko S. , Yaremchuk A.
Published: January 2022

Dogs are naturally characterized by a high level ofinjuries, which can reach up to 50 % of the total surgicalpathology. At the same time, abdominal pathology issignificantly common in this species of animals andsurgical treatment of the sepathologies is accompanied bya significant somatic and visceral pain response. The workwas performed at the Department of Surgery and Diseasesof Small Pets of Bila Tserkva National Agrarian Universityin the period 2015-2020. The material for the study wereclinically healthy and sick dogs admitted to the clinic ofdiseases of small animals of the university. Forming theclinical-experimental base for research, nosological formsof pathology and frequency of its occurrence were taken into account, attention was paid to the peculiarities of surgicalintervention depending on the species of animals, type andintensity of pain response and correctness of anesthesia.Visceral type of pain reaction was studied in dogs aged2 to 10 years, who underwent abdominal surgery. Somaticpain reaction accompanies bone fractures and their surgicaltreatment. Included in the study of dogs with fractures of thefemur or humerus aged from 1 to 10 years.High levels of endotoxicosis are characteristic of thepathochemical phase of abdominal surgical pathology in dogs,with the concentration in the blood of malonic dialdehyde(14.8 ± 0.55 μmol / l) and molecules of average weight isrespectively 1.6 and twice higher than normal. However,the lowest level was found under balanced acepromazineketamine-propofol anesthesia, with no probable changes inmolecular weight peptides and a slight increase in the level ofmalonic dialdehyde only 1.1 times (p <0,01).Acepromazine-butorphanol-propofol-ketamineanesthesia for somatic pain in dogs provides completeanalgesia with controlled and rapid recovery fromanesthesia without established probable changes during theoperation of spectral indicators of heart rate variability. Insomatic pain in dogs, regardless of the anesthesia regimen,the preoperative level of endotoxemia is preserved, andaccording to the spectral analysis of HRV and its sympathoparasympathetic balance index, 30 % of surgically ill dogsshow normotonia – 0.85–1.15, 27 – sympathicotonia (LF/HF>1.15), in 43 % – parasimaticotonia (LF/HF<0.85),which is the key criterion for selecting the appropriatescheme of anesthesia.
Key words: heart rate variability, endogenousintoxication, anesthesia, dogs, types of pain reaction, visceralinnervation, somatic innervation.
Age dynamics of biochemical parameters of the blood of deep-calving cows
Authors: Koreyba L. , Duda Yu.
Published: January 2022

The study of changes in the system of metabolichomeostasis of dry-lasting cows in the winter-stable periodis important in maintaining their productive and reproductivestate whereas this periodis one of the most difficult for thebody, as the most stressful factors: lack of exercise and solarinsolation; the action of potentially pathogenic microflora andincreased level of gassiness in livestock premises; possibleinsufficiency in the nourishment of vitamins and macromicroelements. The action of stress factors causes metabolic disorders,which often occur without visible clinical features.The indicators, which changing of the state of energy,protein, vitamin and mineral nutrition of the animal body,are necessary to determine during monitoring.The dynamics of total protein content was determined bythe biuret method, albumin – by the reaction of bromocresolgreen, the activity of alanine and aspartate aminotransferases(ALT and AST) – by the Reitman-Frenkel method, theactivity of alkaline phosphatase and phosphate phosphatasecarotene content – photometric method, total calcium content– complexometric method and carotene content – photometricmethod in the blood of deep-boiled cows during the winterstable content.A decrease in total protein content was indicated incows with fourth calving in a month before calving up to76.08±2.47 g/l. Incowswiththe 4th and 6th calving, theprotein level was the lowest, in relation to other experimentalgroups of animals, and was 76.08±2.47 and 76.43±2.97 g/l,respectively. The fractional spectrum of globulins tendedto decrease in cows from the second to the fourth calving.Absolute values of ALT activity in animals with 3rd,4 rd and6th calving were 2-fold (p<0.01) lower than in the 2nd and5rd. There was also a tendency to reduce AST in older cows,but a significant decrease compared to the second pregnancywas found only in animals of the sixth calving (about 20 %).The content of total calcium in the serum of drylasting cows of all experimental periods of calving wasbelow the normal line and ranged from 2.15±0.29 mmol/lto 2.30±0.19 mmol/l. The content of inorganic phosphoruswith an increasing number of calving in dry-lasting animalsgradually decreased from 1.83± 0.19 mmol/l to 1.63±0.16mmol/l and approached the minimum limit of normal. Thecalcium-phosphorus ratio in animals in the second and thirdcalving corresponded to the minimum allowable values(1.2: 1). Increases in carotene content were observed at thefourth (0.46±0.09 μM/l), fifth (0.53±0.08 μM/l) andsixth(0.74±0.10 μM/l) calving. The index of acid capacity tendsto increase in cows with the third (412.73±15.37 mm/l)andfourth (385.00±12.17 mm/l) pregnancy.
Key words: dry-lasting cows, winter-stable and drylasting period, blood serum, biochemical research.
Prevalence and antimicrobial sensitivity profile of uropathogens in a tertiary care hospital of Dhaka city
Authors: Rahman Farha , Akhter Hasina , Hasnat Shahed , Begum Nilufar
Published: January 2022

Urinary tract infection (UTI) is one of the most frequently occurring infections worldwide seeking medical attentions. The etiology of UTI and the antimicrobial sensitivity pattern of uropathogens vary in regions and change through time. This study aims to evaluate the pathogens responsible for causing UTI and analyze the antimicrobial sensitivity pattern of the isolated uropathogens. This cross sectional study was carried out in the Department of Microbiology, Bangladesh Medical College, Dhaka over a period of January 2018 to December 2019. Out of 11,274 urine samples, 1452 (12.88%) were positive for uropathogens by culture. Among these 1452 isolates, majority of them 936 (64.46%) were isolated from females. Escherichia coli 899 (61.91%) was the predominant organism followed by Enterococccus species 168 (11.57%), Klebsiella species 140 (9.64%), Enterobacter species 137 (9.44%). Escherichia coli showed high rate of sensitivity to nitrofurantoin 79.76%, gentamicin 75.31%, amikacin 88.65%, imipenem 97.89% and meropenem 80.87%. Pseudomonas species showed high rate of sensitivity to imipenem 70.45%. Enterococcus species showed high rate of sensitivity to vancomycin 94.05%, imipenem 70.83% and linezolid 79.76%. UTI is a very common problem and rate of antimicrobial resistance is increasing day by day. Therefore, each institution should have an antibiotic policy based on the local antibiogram which is to be renewed regularly.

Bangladesh J Med Microbiol 2020; 14 (2): 3-11
Serological and Molecular Epidemiology of Human Brucellosis in Mymensingh region Bangladesh
Authors: Md Rasheduzzaman - , Hossain Muhammad Akram , Paul Shyamal Kumar , Nasreen Syeda Anjuman , Haque Nazia , Akter Ayenun , Muhammadullah Sikdar , Kabir Md Humayun , Sonia Suraiya Jahan , Ahmed Salma
Published: January 2022

Brucellosis is a major Bacterial Zoonotic disease worldwide. More than 500,000 new cases are reported globally every year with the annual incidence rates varying widely from <2 to >500 per 1000,000 population among different region of the world. This cross sectional descriptive study was carried out in the department of microbiology, Mymensingh medical college, Mymensingh, Bangladesh from 1st January to 31 December 2017, on total 600 patients of PUO with or without occupational exposure. Blood was taken as sample, serum was separated and screening test was done by Brucella specific latex agglutination test from all collected samples. A Titer of ≥ 1:160 was taken as positive. ICT, PCR and real time PCR were done from all screening positive samples. Among the study population 65.83% (395/600) were male and 34.17% (205/600) were female. The sero prevalence of Human Brucellosis was found 13.33% (40/300) and 5% (15/300), respectively in risk and non risk group of population. Out of 55 Brucella specific latex agglutination test positive samples 27.27% (15/55) were ICT positive, 5.45% (3/55) were PCR positive and 3.64% (2/55) were real time PCR positive. No ICT, PCR or Real time PCR cases were found from sero negative samples. Among the ICT positive cases 86.67% (13/15) from risk group and 13.33% (2/15) from non risk group of study population. Among the 3 PCR positive cases 13.33% (2/15) were from ICT positive cases and 2.5 % (1/40) from ICT negative cases. All PCR and Real time PCR positive cases were found in risk group of study population. No reliable data for Human Brucellosis is available in our country. However the present study revealed that a considerable number of Human Brucellosis is present in risk group as well as non risk group of population in both rural and urban area in Mymensingh district of Bangladesh. In our country we use only Brucella specific latex agglutination test for diagnosis of human Brucellosis. It is a non specific test and gives many false positive results. So it is necessary to introduce newer tests with higher sensitivity and specificity which will help to diagnose the disease rapidly and more accurately.

Bangladesh J Med Microbiol 2020; 14 (2): 19-24
The prevalence of asymptomatic COVID-19 cases in a single center and duration of viral clearance
Authors: Akram Arifa , Islam Md Tanjimul , Rahman Md Ashiqur , Islam Md Raihanul , Ali Md Mahbub , Islam Toufiqul , Akram Lubana , Reza Md Alimur
Published: January 2022

Background: The COVID-19 pandemic is already a public health emergency and led to millions of cases and deaths worldwide since its outbreak on December 2019. Public health responses is not seen to identify asymptomatic individuals who are also infectious. Data are also limited on the duration of viral clearance.

Methods: Retrospectively and randomly selected 2117 cases who came to do PCR for COVID-19 in Novus molecular Lab, Dhaka between 5 March 2021 and 5 May 2021. Laboratory data and patient's characteristics, such as age, sex, and other relevant history were collected from our laboratory database.

Results: Among 2117 cases (symptomatic or asymptomatic patients), SARS_CoV_2 RNA was detected in 501 samples (24%). Among 501 positive cases 352 were male and 149 were female with the mean age of 34.81 (SD±12). The most common complaints were fatigue (68%), high temperature (57%); but anosmia and ageusia were present among 57% cases in symptomatic and also asymptomatic groups. Among the positive cases, 30-39 years of age group was mostly affected followed by 19-29 years. 48% asymptomatic cases were found among the positive cases. The mean CT value was significantly higher in asymptomatic (24.5 ± 0.4), compared to symptomatic (23.37± 0.3). The median duration of viral conversion in this study was 20 days (IQR 16–33 days).

Conclusion: We found those people having symptoms have delayed viral clearance. These data disclose the high asymptomatic incidence of SARS-CoV-2 infection in Bangladesh, and that these cases may act as carrier. Public health expert should think for routine screening in office or other area to identify asymptomatic cases and to contain the outbreak.

Bangladesh J Med Microbiol 2021; 15 (1): 3-7
Diversity of Dengue Virus Serotypes in Dhaka City: From 2017 to 2021
Authors: Rahim Rummana , Hasan Abu , Hasan Nazmul , Nakayama Emi E , Shioda Tatsuo , Rahman Mizanur
Published: January 2022

This is a retrospective observational study aimed to search the alteration of circulating dengue virus (DENV) serotypes in Dhaka City for five consecutive years (2017-2021) along with disease outcome.

Methods: Routine dengue NS1 or PCR positive dengue samples from patients who visited Evercare Hospital Dhaka (ex. Apollo Hospitals Dhaka) were selected for serotype determination by serotype specific real time reverse transcriptase PCR (RT-PCR).

Results: In 2017, predominant serotype was DENV-2 (91.3%) with less than 5% of DENV-1 and DENV-3 among 161 cases. In 2018, among127 cases, DENV-2 was the predominant serotype (40.95%) followed by DENV-3 (33.07%) and DENV-1 (25.98%). In 2019, predominance of DENV-2 was totally replaced by DENV-3 (91.86%) and DENV-1 (8.14%). In 2021, only DENV-3 serotype was detected among 178 samples. Regarding serotype association with disease outcome, more severe cases (Dengue Hemorrhagic Fever/Dengue Shock Syndrome) were observed from 2019 with notable shifting of serotype dominance to DENV-3 from DENV-2 in previous years. In our cohort, the prevailing age group was 1-20 years which is analogous with many studies in Asia.

Conclusion: Dominance of DENV serotype shifted to DENV-3 in 2019 from prolonged persistence of DENV-2 and DENV-1. Continuous surveillance for circulating DENV serotype is needed for preparedness of potential outbreaks and occurrence of severe cases.

Bangladesh J Med Microbiol 2021; 15 (2): 23-29
Pendampingan Pelaku Usaha Melalui Dempond Pembenihan Ikan Lele (Clarias gariepinus) dan Pemasaran di Kecamatan Kalirejo, Kabupaten Lampung Tengah, Provinsi Lampung
Authors: Prastiyo Bayu , Eliyani Yuke , Saman Asnawi , Hendriawan Basuki
Published: January 2022

Penelitian dilaksanakan di Kelompok Taruna Mina Karya, Kecamatan Kalirejo Provinsi Lampung, mulai tanggal 8 Maret sampai 5 Juni 2021.Tujuan kegiatan ini meningkatkan hasil produksi benih melalui pemijahan buatan pada pembenihan ikan lele, serta meningkatkan kemampuan pelaku usaha untuk memperluas wilayah pemasaran benih ikan lele melalui media internet. Aksi penyuluhan adalah dempond pembenihan ikan lele secara buatan serta proses pemasaran daring. Hasil pelaksanaan kegiatan penyuluhan perikanan yaitu : (a) dempond pemijahan buatan ikan lele menggunakan perbandingan dua ekor  induk jantan dan satu ekor induk betina dengan hasil produksi benih yang diperoleh 67.740 ekor. Proses dempond pembenihan ikan lele secara buatan terbukti dapat meningkatkan hasil produksi dilihat dari perbandingan hasil produksi dengan metode pemijahan alami yang menggunakan dua induk betina hanya menghasilkan 85.000 ekor. (b) pemasaran daring yang dilakukan telah menjangkau wilayah pasar yang lebih luas sampai keluar Provinsi lampung antara lain yaitu wilayah Tangerang dan Bogor. Pemasaran melalui media internet dapat meningkatkan harga jual, di mana yang sebelumnya hanya mencapai Rp.90 - Rp.100 per ekor pada ukuran benih 5-7 cm setelah melakukan pemasaran melalui internet harga jual benih menjadi Rp.150 – Rp.170 per ekor. Aspek pengetahuan mengalami peningkatan rata-rata 43%, aspek sikap menunjukkan perubahan dari kategori tidak setuju menjadi kategori setuju dengan nilai mutlak 90 %. Aspek keterampilan berubah dari kategori tidak terampil rata-rata menjadi cukup terampil.
A multicriteria decision analysis (MCDA) applied to three long-term prophylactic treatments for hereditary angioedema in Spain
Authors: Zozaya Néboa , Caballero Teresa , González-Quevedo Teresa , Gamboa Setien Pedro , González M. Ángeles , Jódar Ramón , Poveda-Andrés José Luis , Guillén-Navarro Encarna , Rivero Cuadrado Agustín , Hidalgo-Vega Álvaro
Published: January 2022

Introduction: Hereditary angioedema (HAE) is a rare genetic disease that impairs quality of life and could be life-threatening. The aim of this study was to apply a multicriteria decision analysis to assess the value of three long-term prophylactic (LTP) therapies for HAE in Spain.
Methods: A multidisciplinary committee of 10 experts assessed the value of lanadelumab (subcutaneous use), C1-inhibitor (C1-INH; intravenous), and danazol (orally), using placebo as comparator. We followed the EVIDEM methodology that considers a set of 13 quantitative criteria. The overall estimated value of each intervention was obtained combining the weighting of each criterion with the scoring of each intervention in each criterion. We used two alternative weighting methods: hierarchical point allocation (HPA) and direct rating scale (DRS). A reevaluation of weightings and scores was performed.
Results: Lanadelumab obtained higher mean scores than C1-INH and danazol in all criteria, except for the cost of the intervention and clinical practice guidelines. Under the HPA method, the estimated values were 0.51 (95% confidence interval [CI]: 0.44-0.58) for lanadelumab, 0.47 (95%CI: 0.41-0.53) for C1-INH, and 0.31 (95%CI: 0.24-0.39) for danazol. Similar results were obtained with the DRS method: 0.51 (95%CI: 0.42-0.60), 0.47 (95%CI: 0.40-0.54), and 0.27 (95%CI: 0.18-0.37), respectively. The comparative cost of the intervention was the only criterion that contributed negatively to the values of lanadelumab and C1-INH. For danazol, four criteria contributed negatively, mainly comparative safety.
Conclusion: Lanadelumab was assessed as a high-value intervention, better than C1-INH and substantially better than danazol for LTP treatment of HAE.
Palatopharyngeal Muscle Suspension Suture Technique for Obstructive Sleep Apnea
Authors: Choi Dong Gyu , Lee Dong Woo , Kim Joo Yeon , Kwon Jae Hwan
Published: January 2022

Various treatment modalities for obstructive sleep apnea (OSA) patients were introduced including continuous positive airway pressure (CPAP), lifestyle modification, and surgery. Numerous factors such as compliance, treatment failure, and preference should be considered when deciding the treatment. In general, patients for whom CPAP or other conservative treatment modalities failed become candidates for surgical treatments. Uvulopalatopharyngoplasty is one of the most generally performed surgeries, of which success rate is relatively low. Recently, numerous techniques that can correct lateral pharyngeal obstruction for OSA patients were introduced. However, some of them are technically difficult and aggressive. In this article, we introduce a novel surgical method for OSA called palatopharyngeal muscle suspension suture technique.
Ensino a distância: conhecimentos, habilidades e competências necessárias para o professor do ensino superior
Authors: Santos Junio Samuel dos , Silva Alecsandro Marian da , Gaspar Guilherme Tadaki Tazo , Batista Caren Stela Máximo , Lima Cássia Luciana de Melo
Published: January 2022

O presente estudo trata do tema do conhecimentos, habilidades e competências necessárias para a docencia no ensino superior na modalidade a distância e seu objetivo é analisar as características necessárias à prática docente para a qualificação do processo ensino-aprendizagem na educação a distância. Para alcançar este objetivo contextualiza o ensino a distância, determina os conhecimentos, habilidades e competências pertinentes à docência a distância no ensino superior onde destaca-se a importância destes parâmetros para o exito na formação do aluno. Por meio de pesquisa bibliográfica qualitativa, conclui que uma formação de qualidade deve adequar-se a uma sociedade plural, heterogênea, dialética e controversa na qual o conhecimento, as habilidades e as competências se encontram também em constante evolução e transformação.
Desenvolvimento das farmácias vivas associado a fatores sociodemográficos brasileiros
Authors: Gondim Jacqueline Marques da Silva , Melo Elaine Silva de Pádua , Alves Junior Ademir da Silva , Nascimento Valter Aragão do
Published: January 2022

O objetivo desse estudo foi analisar a implementação da Política Nacional de Plantas Medicinais e Fitoterápicos no Sistema Único de Saúde brasileiro por meio das Farmácias Vivas. A metodologia consiste em uma pesquisa documental e bibliográfica, de caráter descritivo, a partir de busca por artigos de periódicos, livros, levantamento de documentos normativos oficiais, em bases de dados como o Portal de Periódicos Capes/MEC, PubMed, Scielo, Google Acadêmico, portal do Ministério da Saúde, Diário Oficial da União, site oficiais das secretarias de saúde, da Anvisa e do IBGE. No período de março de 2020 e outubro de 2020. Para levantamento de ações, políticas públicas e regulatórias no âmbito das plantas medicinais e fitoterápicos, foram buscadas normativas entre os anos de 1982 e 2009. Foi considerado o período de 1983 a 2020 para análise da institucionalização das Farmácias Vivas. Em relação aos recursos públicos foram considerados editais no período de 2012 a 2020; e para os dados sociodemográficos, resgatou-se o período de 2012 a 2020, com as publicações do Ministério da Saúde. Como resultado, observa-se que as ações, políticas públicas e regulatórias contribuíram para a expansão dos programas de plantas medicinais e fitoterapia pelo Brasil, e das Farmácias Vivas no âmbito do SUS. Concluiu-se que os recursos financeiros foram disponibilizados com regularidade e destinação específica, porém distribuindo-se de forma desigual, considerando as necessidades sociodemográficas regionais. Seria necessário maior aporte financeiro para as regiões de maior fragilidade socioeconômica, a desburocratização dos trâmites para acesso aos recursos, e o fortalecimento das políticas públicas regionais.
Desenvolvimento, Satisfação e Usabilidade de plataforma móvel para monitoramento da saúde mental de estudantes universitários
Authors: Ferreira Lucas Fortaleza de Aquino , Benevides Ana Maria Luna Neri , Rabelo Jayanne Antonia Ferreira , Medeiros Melissa Soares , Barros Filho Edgar Marçal de , Sanders Lia Lira Olivier , Peixoto Raquel Autran Coelho
Published: January 2022

Objetivo: Este estudo objetivou desenvolver e avaliar usabilidade e satisfação um aplicativo para smartphone (App) que facilite a triagem e o acompanhamento de sintomas emocionais e fatores associados à saúde mental de universitários. Metodologia: Trata-se de um estudo transversal, com aplicação de questionários por Google Forms® entre alunos do curso de medicina de um Centro Universitário, entre julho de 2020 a novembro 2021. Após uso do App desenvolvido por uma equipe multiprofissional, os alunos responderam a dados clínico-demográficos, uma versão em português da escala de usabilidade do sistema (SUS-System Usability Scale) e um questionário sobre a satisfação com o aplicativo. Resultados: O App, disponível para plataformas Android e iOS, continha 32 questões autoaplicáveis de escalas validadas no Brasil sobre depressão, ansiedade, estresse, insônia e sedentarismo (Depression, Anxiety and Stress Scale -DASS-21, Insomnia Severity Index -ISI e International Physical Activity Questionnaire -IPAQ). Ao término das respostas, forneciam-se interpretações baseados nas pontuações obtidas, incluindo orientações sobre quando buscar ajuda profissional e conteúdos educativos. 31 alunos responderam aos questionários de usabilidade e satisfação após testarem o App. A idade média foi de 25,2 anos. 16,1% tinham diagnóstico prévio ou atual de transtorno depressivo, e 41,9% de ansiedade. O valor de escore médio da escala SUS foi de 84. Todos os alunos ficaram satisfeitos com o aplicativo, e o recomendariam a outro colega. Conclusão: Houve boa usabilidade e satisfação, sugerindo potencial de triagem e monitoramento do App de transtornos mentais entre estudantes de medicina.
Indicadores de saúde da pessoa idosa no nordeste brasileiro
Authors: Porto Elisangela , Costa Sueli de Souza , Porto Edivânia , Cavalcante Yara Maria
Published: January 2022

O envelhecimento rápido da população idosa brasileira causou transformações com problemas complexos na área da saúde pública e desafios para profissionais de saúde na promoção, prevenção e tratamento de enfermidades crônico-degenerativas. Objetivo: analisar os indicadores de saúde da pessoa idosa nos estados do Nordeste brasileiro. Metodologia: estudo descritivo analítico transversal com dados coletados pelo Sistema de Informação de Saúde e Acompanhamento de Políticas do Idoso (SISAP- Idoso) nos nove estados do Nordeste e complementados pelo Instituto Brasileiro de Geografia e Estatística (IBGE), entre 2015 a 2019. Foram utilizados indicadores demográficos, socioeconômicos, mortalidade, morbidade e serviços de saúde. Os dados foram processados pelo programa estatístico Excel 2010 e Stata versão 15 e a associação entre os indicadores foi feita pela correlação de Pearson. Resultados: Alagoas teve a maior proporção de óbitos e o Maranhão a maior morbidade por causas evitáveis, maior proporção de óbitos por hipertensão e o menor número de médicos/habitantes. A hipertensão foi a doença mais passível de controle na atenção básica, tendo forte correlação como causa de hospitalização e mortalidade evitável. O conhecimento dos indicadores de saúde pode contribuir para o fortalecimento da atenção básica no Nordeste, sobretudo nos estados mais fragilizados, dando ênfase às doenças de fácil controle como a hipertensão, porém, com forte impacto nos indicadores de saúde da região.
Avaliação da resistência ao cisalhamento de resinas compostas flow autoadesivos versus convencionais: uma revisão sistemática
Authors: Zanatta Cassia Thaís Iurkiv , Silva Stéphane Vanelli da , Bonamin Stephanie , Camilotti Veridiana , Mendonça Márcio José , Ueda Julio Katuhide
Published: January 2022

Pouco se sabe sobre as resinas compostas fluidas autoadesivas, uma vez que a maior parte da literatura menciona as resinas compostas fluidas convencionais. Então, o objetivo do presente trabalho foi revisar exclusivamente o comportamento da adesão ao esmalte e à dentina das resinas compostas fluidas autoadesivas em comparação com a resina composta fluida convencional. Uma pesquisa bibliográfica foi realizada de 2010 a 2021 na base de dados Pubmed. O termo de busca utilizado foi “self-adhering flowable composite”, onde 61 artigos completos foram avaliados e somente 11 foram selecionados. Foram elegíveis para a seleção apenas estudos que avaliaram a resistência de união pelo teste de cisalhamento ou microcisalhamento da resina composta fluida autoadesiva aplicada na estrutura dental. Com base nessa revisão sistemática, conclui-se que a resina fluida autoadesiva demonstrou valores de resistência de união ao esmalte e à dentina inferior que a resina fluida convencional. A associação do sistema adesivo de condicionamento ácido total com resina fluida autoadesiva mostrou valores de resistência de união maior que o uso dos autoadesivos sozinhos. A resina fluida autoadesiva obteve valores de resistência de união similar aos materiais restauradores à base de ionômero de vidro.
Fatores influenciadores para adesão à vacina contra o papilomavírus humano: uma revisão integrativa
Authors: Romeu Wédila Renata Oliveira Grangeiro , Gomes Emiliana Bezerra , Sampaio Larissa Alves , Carneiro Yasmin Ventura Andrade , Beltrão Izabel Cristina Santiago Lemos de , Cruz Rachel de Sá Barreto Luna Callou , Oliveira Dayanne Rakelly de
Published: January 2022

Objetivo:  Analisar os fatores que influenciam à adesão à vacina contra o Papilomavírus Humano em meninos escolares. Metodologia: Revisão integrativa da literatura (RIL), ocorreu no período fevereiro a abril de 2018. A revisão integrativa foi realizada na Biblioteca Virtual em Saúde (BVS), a qual inclui a Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), IBECS, Medical Literature Analysis and Retrieval System Online (MEDLINE), Biblioteca Cochrane e a Scientific Electronic Library Online (SciELO). Após a leitura e aplicação dos critérios foram elegidos 22 artigos para análise na íntegra. Resultados: Quanto aos fatores influenciadores à adesão à vacina contra o HPV, estes foram divididos em dois grupos: fatores positivos e fatores negativos. Dentro de cada grupo, foram eleitos os aspectos mais abordados nos estudos, possibilitando agrupá-los para uma melhor compreensão, elencados em três grupos: Conhecimentos, atitudes e percepções dos pais/responsáveis; Fatores socioculturais e educação em saúde. Conclusão: Os estudos trazem diversos influenciadores no processo de tomada de decisão, tanto positivos quanto negativos em relação à aceitação da vacina. Os fatores aqui descritos são de grande relevância, pois através do conhecimento destes, profissionais de saúde poderão estabelecer um papel ativo na elaboração de estratégias que visem uma maior adesão à campanha de vacinação contra o Papilomavírus Humano (HPV).
Institucionalização da assistência farmacêutica no município de Augusto Corrêa, Pará
Authors: Ferreira Tassio Luís Silva , Silva Taize Catarina Monteiro , Costa Bruno Wesley Bezerra , Lima Gustavo Campos de , Castanho Kelly Crisane de Oliveira Castro , Soler Orenzio
Published: January 2022

Objetivo: Investigar a institucionalização da assistência farmacêutica no município de Augusto Corrêa, Pará. Método: Pesquisa exploratória, retrospectiva e descritiva, realizada em 2021. Para obtenção de indicadores socioeconômicos, demográficos, epidemiológicos, serviços de saúde, despesas totais em saúde, utilizou-se dados do Cadastro de Estabelecimentos de Saúde do Departamento de Informática do SUS, do Instituto Brasileiro de Geografia e Estatística, do Instituto de Pesquisa Econômica Aplicada e do Sistema de Informação de Atenção Básica. Para as informações sobre práticas de governança, planejamento, gestão, componentes técnicos-gerenciais e  técnicos-assistenciais da Assistência Farmacêutica, utilizou-se formulários estruturados, aplicados por meio da ferramenta Survey Monkey®, via Internet®, à coordenação da Assistência Farmacêutica da Secretaria Municipal de Saúde do município de Augusto Corrêa, Pará. Resultados: Augusto Corrêa tem uma População Estimada de 46.937 habitantes em 2021 e Densidade Demográfica de 37,10 habitantes/km² em 2010. Área Territorial de 1.099,619 km² em 2020. Faz parte do Bioma Amazônia, da Mesorregião Nordeste Paraense, Microrregião Bragantina. 0,520 de Índice de Desenvolvimento Humano Municipal em 2010. 0,4145 de Índice de Gini da Renda Domiciliar Percapta em 2010. Não cumpre integralmente as práticas de governança no nível da coordenação técnica de assistência farmacêutica; em especial, pessoal e competências, princípios e comportamentos, liderança organizacional, relacionamento com partes interessadas, estratégia organizacional, alinhamento transorganizacional, estrutura de governança, gestão de risco e controle interno, auditoria interna, accountability e transparência. Também, não cumpri todos os componentes para a Gestão Técnica da Assistência Farmacêutica e a Gestão Clínica do Medicamento. Conclusão: Constatou-se o não cumprimento integral dos componentes da gestão técnica da assistência farmacêutica e da gestão clínica do medicamento; assim como, as práticas de governança no nível da coordenação técnica de assistência farmacêutica precisam ser aprimoradas; em especial, pessoal e competências, princípios e comportamentos, liderança organizacional, relacionamento com partes interessadas, estratégia organizacional, alinhamento transorganizacional, estrutura de governança, gestão de risco e controle interno, auditoria interna, accountability e transparência.
Metilação de CDH1 em lavados peritoneais como fator prognóstico para câncer gástrico
Authors: Oliveira Ana Carolina Favacho Miranda de , Modesto Antonio André Conde , Moreira Fabiano Cordeiro , Araújo Taíssa Maíra Thomaz , Silva Marcelli Geise de Oliveira Prata da , Assumpção Paulo Pimentel , Ishak Geraldo , Borges Bárbara do Nascimento , Khayat André Salim
Published: January 2022

O câncer gástrico é um importante problema de saúde pública, considerado o quinto câncer mais diagnosticado no mundo. A metástase peritoneal é uma das principais causas de mortalidade relacionadas ao câncer gástrico. A hipermetilação de genes supressores de tumor é um fator promissor para o desenvolvimento de biomarcadores preditivos. Em tumores gástricos, a expressão reduzida do gene supressor CDH1 contribui para a invasão tumoral e desencadeamento de metástases. Nosso objetivo foi avaliar o perfil de metilação da região promotora do gene CDH1 como indicador de metástase peritoneal em pacientes com câncer gástrico. O perfil de metilação de CDH1 foi avaliado em 47 amostras de lavados peritoneais de pacientes com câncer gástrico por PCR de sequenciamento de bissulfito (BSP). Trinta e três sítios CpGs na região do promotor CDH1 foram avaliados individualmente. Amostras com ≥ 10% de sítios CpGs metilados foram consideradas hipermetiladas. A análise estatística foi realizada pelo teste Exato de Fisher, utilizando o programa R-Studio (p≤0,05). Vinte e nove (62%) amostras apresentaram hipermetilação na região promotora de CDH1, com metilação preferencial nos sítios CpGs localizados na região 5' a montante do gene. A análise estatística mostrou que a hipermetilação de CDH1 foi significativamente diferente em pacientes com estágios avançados de profundidade de invasão do tumor (p=0,03). Nossos resultados sugerem que a análise de metilação do gene CDH1 é uma ferramenta útil na predição de progressão e invasividade tumoral em pacientes com câncer gástrico e pode ter um grande impacto para o campo da medicina de precisão do câncer.
Potencial de utilização de resíduos da cultura de soja tratados com água e hidróxido de sódio para produção de painéis aglomerados
Authors: Borges Ianca Oliveira , Miranda Eduardo Hélio de Novais , Brito Flávia Maria Silva , Altafin Nayara Cristina da Silva , Mendes Lourival Marin , Guimarães Júnior Jose Benedito
Published: January 2022

O Brasil é um dos maiores produtores de soja e, consequentemente, gera uma grande quantidade de resíduos provenientes dessa cultura, os quais poderiam ser aproveitados na confecção de aglomerados. Este trabalho objetivou analisar as características físico-mecânicas de painéis aglomerados, produzidos com partículas de resíduos de soja e eucalipto, tratadas em água fria e hidróxido de sódio. Adotou-se uma proporção de 50:50 de partículas de eucalipto e casquilho de soja. A densidade nominal dos painéis foi 0,60 g/cm³. Foi utilizado adesivo uréia-formaldeído com teor de sólidos de 12 %. Foram adotados três tratamentos: partículas tratadas com água fria e partículas tratadas com NaOH (com concentração de 1%, além de um tratamento com partículas controle. Os componentes químicos dos materiais lignocelulósicos foram quantificados para as três situações. Os parâmetros do ciclo de prensagem foram: 4 MPa (pressão), 150 °C (temperatura), durante 8 min.  Foram observadas reduções nos teores de extrativos totais, após os tratamentos. Em relação às propriedades físicas, os tratamentos aplicados nas partículas não demonstraram eficiência, pois não trouxeram melhorias para a estabilidade dimensional dos painéis e nenhum dos tratamentos atingiram ao valor mínimo especificado pela norma utilizada. Para as propriedades mecânicas, os painéis produzidos com partículas tratadas com água atenderam as exigências para o MOE. Para as propriedades de tração perpendicular e dureza Janka, todos os painéis alcançaram os valores especificados pela NBR 14810 (2013). As outras propriedades testadas (MOR, APS e APT) não atenderam a norma. Os tratamentos aplicados nas partículas de soja e eucalipto não demonstraram eficiência para as propriedades físicas, porém algumas propriedades mecânicas atenderam aos requisitos mínimos da NBR 14810 (2013) para painéis não estruturais para uso interno em ambiente seco (Tipo P2).