bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular classification of high-grade, muscle-invasive urothelial carcinomas and the relationship with CTLA-4 and PD-L1 expression
Authors: Pereira Fabiana T. B. , Mattos Tatiana V. A. , Martini Filho Dino , da Silva Maria Antonieta L. G. , Fernandes Roni C. , Montor Wagner R.
Published: December 2023

Purpose

the aim of the current study was to molecularly classify high-grade, muscle-invasive, urothelial carcinoma of basal, luminal, and p53-like subtypes and to assess their relationship with CTLA-4 and PD-L1 expression.

Methods

fifty-seven samples from transurethral resections were tested immunohistochemically for CK5/6, CD44, CK20, p63, p53, and CTLA-4/PD-L1.

Results

about half of the cases presented a basal molecular profile (50.9%), the luminal profile was found in 29.8% and the p53-like profile in 15.8%. Positivity for CTLA-4 occurred in 24 samples (42.1%), with cytoplasmic and membrane expression reported only in neoplastic cells. Of these, 11 were of the luminal subtype, ten were of the basal subtype, and three were of the p53-like subtype. There was an association between CTLA-4 expression and the luminal classification, and an absence of CTLA-4 expression in the basal profile (p = 0.047). PD-L1 expression was found in 12 samples, ten of them classified as the basal subtype (p = 0.036). CTLA-4 and PD-L1 expression were not identified in the same subtypes (p = 0.08), since only one sample was positive for both markers.

Conclusions

A molecular classification into the subtypes was possible in 96.5% of cases of high-grade, muscle-invasive, urothelial carcinoma using immunohistochemistry. Thus, this type of classification is viable in most surgical pathology laboratories, including those in Brazil’s Unified Health System (known as SUS, the acronym for Sistema Único de Saúde). The expression of CTLA-4 is related to the luminal molecular subtype, while the expression of PD-L1 is related to the basal molecular subtype. CTLA-4 and PD-L1 positivity are mutually exclusive.
Reduction in Pappalysin-2 Levels and Lower IGF-I Bioavailability in Female Adolescents With Anorexia Nervosa
Authors: Barrios Vicente , Martín-Rivada Álvaro , Guerra-Cantera Santiago , Campillo-Calatayud Ana , Camarneiro Ricardo A , Graell Montserrat , Chowen Julie A , Argente Jesús
Published: December 2023

Context

Anorexia nervosa (AN) can cause severe undernutrition associated with alterations in the IGF axis. Pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC-1, STC-2) modulate IGF binding-protein (IGFBP) cleavage and IGF bioavailability, but their implications in AN are unknown.

Objective

We determined serum levels of PAPP-As and STCs in relationship with classical IGF axis parameters in female adolescents with AN and their association with nutritional status and secondary amenorrhea.

Methods

Parameters of the IGF axis were determined in fasting serum samples of 68 female adolescents with AN at diagnosis and 62 sex- and age-matched controls. Standardized body mass index (BMI) and bone mineral density (BMD) were calculated.

Results

Patients with AN had lower concentrations of total and free IGF-I, total IGFBP-3, acid-labile subunit (ALS), insulin, PAPP-A2, STC-1, and STC-2 and higher levels of IGF-II and IGFBP-2. Their free/total IGF-I ratio was decreased and the intact/total IGFBP-3 and −4 ratios increased. BMI was directly related to total IGF-I and intact IGFBP-3 and inversely with IGFBP-2 and intact IGFBP-4. Weight loss was directly correlated with intact IGFBP-4 and negatively with intact IGFBP-3, ALS, STC-2, and PAPP-A2 concentrations. BMD was directly related to intact IGFBP-3 and inversely with intact IGFBP-4 and PAPP-A2 levels. Patients with amenorrhea had lower levels of total IGF-I and IGFBP-3 than those with menses.

Conclusion

The reduction of PAPP-A2 in patients with AN may be involved in a decline in IGFBP cleavage, which could underlie the decrease in IGF-I bioavailability that is influenced by nutritional status and amenorrhea.
Gene Expression Signatures Predict First-Year Response to Somapacitan Treatment in Children With Growth Hormone Deficiency
Authors: Garner Terence , Clayton Peter , Højby Michael , Murray Philip , Stevens Adam
Published: December 2023

Context

The pretreatment blood transcriptome predicts growth response to daily growth hormone (GH) therapy with high accuracy.

Objective

Investigate response prediction using pretreatment transcriptome in children with GH deficiency (GHD) treated with once-weekly somapacitan, a novel long-acting GH.

Methods

REAL4 is a randomized, multinational, open-label, active-controlled parallel group phase 3 trial, comprising a 52-week main phase and an ongoing 3-year safety extension (NCT03811535). A total of 128/200 treatment-naïve prepubertal children with GHD consented to baseline blood transcriptome profiling. They were randomized 2:1 to subcutaneous somapacitan (0.16 mg/kg/week) or daily GH (0.034 mg/kg/day). Differential RNA-seq analysis and machine learning were used to predict therapy response.

Results

121/128 samples passed quality control. Children treated with somapacitan (n = 76) or daily GH (n = 45) were categorized based on fastest and slowest growing quartiles at week 52. Prediction of height velocity (HV; cm/year) was excellent for both treatments (out of bag [OOB] area under curve [AUC]: 0.98-0.99; validation AUC: 0.83-0.84), as was prediction of secondary markers of growth response: HV standard deviation score (SDS) (0.99-1.0; 0.75-0.78), change from baseline height SDS (ΔHSDS) (0.98-1.0; 0.61-0.75), and change from baseline insulin-like growth factor-I SDS (ΔIGF-I SDS) (0.96-1.0; 0.85-0.88). Genes previously identified as predictive of GH therapy response were consistently better at predicting the fastest growers in both treatments in this study (OOB AUC: 0.93-0.97) than the slowest (0.67-0.85).

Conclusion

Pretreatment transcriptome predicts first-year growth response in somapacitan-treated children with GHD. A common set of genes can predict the treatment response to both once-weekly somapacitan and conventional daily GH. This approach could potentially be developed into a clinically applicable pretreatment test to improve clinical management.
Niemann-Pick Disease With Bilateral Adrenal Mass
Authors: Long Mohd Noor Affendi Sharifah Noor Adrilla binti , Tong Chin Voon , Nordin Nurul Dayana binti
Published: December 2023

Niemann–Pick disease (NPD) is a heterogeneous group of lysosomal storage disorders with autosomal recessive inheritance pattern. There are 4 types of NPD. Patients with NPD type B generally have better prognosis, allowing them to survive into adulthood. They have a widespread clinical presentation, affecting multiple organs but rarely neurological involvement. Here, we describe the case of a 38-year-old woman with unexplained hepatosplenomegaly and young hypertensive intracranial bleed. Evaluation for young hypertension further revealed a nonfunctional bilateral adrenal mass and gross hepatosplenomegaly. NPD was confirmed through dried blood spot investigation. It showed low activity of acid sphingomyelinase and genetic testing also detected 2 pathogenic mutations. She is being managed by a multidisciplinary team for supportive treatment that includes regular symptoms monitoring and genetic counseling.
THE 14TH INFANTRY DIVISION OF THE SOUTH-EASTERN FRONT IN OCTOBER-DECEMBER 1919
Authors: Gnido Sergey V.
Published: December 2023

Purpose. The purpose of the article is to investigate the general nature and the main content of combat operations of the 14th Infantry Division, as well as the party-political work of its command to fulfill the combat tasks in the period from September 1919, when the division joined the newly formed Southeastern Front of the Red Army, and up to the forcing of the Don and the beginning of active combat operations on its right bank (December 1919).

Method and methodology. The general methodological approach to the research is based on the basic principles and methods of scientific and historical cognition. The priority scientific methods in this study were the general scientific methods of analysis, synthesis, classification, analogy, as well as methods of historical analysis (descriptive, comparative-historical, logical, retrospective, method of frontal analysis of archival materials).

Results. The results of the research showed that the 14th Division of the 9th Army of the Southeastern Front was able to recover from its almost complete defeat in early October 1919. It continued to fulfill the tasks on its section of the front. In the life of the division there was a place for party-political work. Going on the offensive to the Khoper River, the division with its actions restrained the enemy forces. Having accomplished the task, the division from the beginning of December went on the active offensive to the Don River. Having forded the Don River, the division continued the offensive on the right bank.

The scope of applicability of results. The results of the research can contribute to a more in-depth study of the Civil War in the period from October to the end of December 1919.
AXIOLOGICAL ASPECT OF THE CONCEPT IDENTITY OPPOSITION REALIZATION (BY THE EXAMPLE OF THE CREATION ‒ DESTRUCTION DICHOTOMY)
Authors: Zdanovskaya Lidia B.
Published: December 2023

Background. The global redistribution of the balance of power, caused by the imbalance of the geopolitical interests of the leading world powers, contributed to the actualization within the boundaries of the Russian linguistic and cultural space of phenomena associated with the accentuation of existential significance categories among which the concept IDENTITY occupies a special position.

Purpose. The article is devoted to the study of the implementation of the value aspect of the concept IDENTITY opposition in Russian linguistic culture.

Materials and methods. The material for this study was the article of the President of the Russian Federation V.V. Putin On the historical unity of Russians and Ukrainians. July, 12, 2021; interview with the Minister of Foreign Affairs of the Russian Federation S.V. Lavrov; Internet publication of the Russian journalist I.A. Yakovenko Disintegration of the Russian Federation: Scenarios and Prospects; speeches of state and political figures of Russia in the television political show Evening with Vladimir Solovyov. When writing the article, the following methods were used: lexical-semantic, comparative-contrastive, discursive, contextual analysis.

Results. In the course of the study the specifics of the differentiated objectification of the concept IDENTITY in the Russian language were analyzed; various theoretical approaches to the substantiation of the oppositional nature of the language implementation of the concept under study were systematized; the factual interdependence of the studied concept with the category “linguistic consciousness” was established; an integrative feature of the implementation of the concept IDENTITY in the Russian language space was revealed; the indicative characteristic of the concept IDENTITY in the composition of the subjects of the opposition CREATION ‒ DESTRUCTION was described.

Practical implications. The results of the study can find practical application in the preparation of teaching aids and textbooks on the linguo-cognitive analysis of concepts based on dichotomous models.
TOWARDS OPTIMISATION OF FORCED HEATING AND COOLING AUTOMATED INFRARED THERMOGRAPH
Authors: FIERRO GIAN PIERO MALFENSE , MEO MICHELE
Published: December 2023

Arguably the two most important characteristics (other than quality of inspection) of non-destructive evaluation (NDE) methods are speed and non-contact inspection. These attributes coupled with real-time, automated, online and/or in-situ methods give an insight into what is expected of future inspection systems. Thermographic imaging methods over the years have been found to be well suited to meet some of these requirements. In this work a novel real-time low-cost automated heating and cooling thermographic system tailored for use within the Industry 4.0 paradigm is evaluated. The focus of this work was to improve damage detection and imaging by the optimisation of heating and/or cooling of components after manufacturing or during maintenance cycles. By changing the heating and cooling patterns during real-time automated inspection the thermographic process can be optimised for damage detection. A carbon fibre reinforced plastic (CFRP) composite sample with flat bottom holes (FBH) was used to evaluate the effective of changing heating and cooling patterns. The system was assessed using three heating/cooling profiles: heating only (HO), cooling only (CO) and heating and cooling (HC). The results show that heating and cooling patterns can play an important role in improving the effectiveness of thermography.
STRUCTURAL UTILIZATION PREDICTION FOR THE HEALTH MONITORING OF TUNNEL LININGS BY MEANS OF AN ARTIFICIAL NEURAL NETWORK ENSEMBLE
Authors: GOTTARDI NICOLA , FREITAG STEFFEN , MESCHKE GUNTHER
Published: December 2023

The continuous expansion of underground structure networks and the necessity of guaranteeing the safety and functionality of the already built tunnels pose the necessity of developing techniques and methods to efficiently achieve these aims. Normally, measured data of different nature are available for tunnels due to sensors installed in the lining. However, adequate procedures have to be implemented to obtain valuable information out of the monitored data. A new method has been developed to achieve a real-time assessment of the stress state in segmental tunnel lining, given specific measured quantities as input. The method is based on the combination of finite element (FE) analyses and feedforward neural networks, which permits to exploit the advantages of both physics-based simulations, representative of the structure considered, and the predictive capabilities of machine learning tools. The FE model of the tunnel lining plays an important role for the reconstruction of the missing quantities, which are not available from monitoring campaigns, but which can be generated by numerical analyses. A Monte Carlo sampling procedure is performed for the definition of multiple sets of the input parameters used in the FE model for the generation of the training data of the metamodels. An ensemble of neural networks is created and assembled into a framework, which is validated against a full scale test where its predictive performances are investigated.
MONITORING THE DEFORMATION PATTERN OF AN INSTRUMENTED CONCRETE ARCH DAM
Authors: SARKAR AVIRUP , PATRA BIKRAM , GHODKE SHARAD , BAGCHI ASHUTOSH
Published: December 2023

Structural Health Monitoring (SHM) and prognosis could play a crucial role in the life cycle of a critical infrastructure such as a large dam. Such monitoring practices serve multiple functions and are essential components in ensuring the safety and effective maintenance of such structures. By providing insights into a structure's behaviour, structural health monitoring assists in calibrating numerical models and complements visual inspections. This process facilitates informed decision-making, aids in planning maintenance and rehabilitation schedules, and ensures the desired safety of the structure throughout its lifespan. This paper presents a case study of a double curvature large thin concrete arch dam that is currently experiencing slow irreversible upstream movement of the central dam crest. The dam is wellinstrumented, with instrumentation falling into categories such as hydrometrological, geotechnical, geodetic, and seismic monitoring. The primary objective of this paper is to validate and establish a level of confidence in numerical modelling by comparing the displacement of an instrumented concrete arch dam with the with that calculated from its finite element method (FEM) model. To achieve this, a sequential thermo-mechanical analysis was performed on a 3D model of the dam foundation reservoir system. Additionally, the study utilizes a well-known statistical model called Hydrostatic-Season-Time (HST) model, based on multi-linear regression analysis, to predict the dam's future displacement using the relevant data from the sensors placed in the dam. The findings indicate a good correlation between the observed dam displacement based on instrumentation data with that calculated from the Finite Element Analysis (FEA) considering the presence of vertical joints. Moreover, the HST model proves to be a suitable choice as it closely matches the observed data and demonstrates good predictive capabilities for future dam behaviour and helps isolate the effects of different parameters on the dam displacement.
STRUCTURAL HEALTH MONITORING OF CFRP PROPELLERS BY PIEZOELECTRIC LINE SENSORS
Authors: HAMADA RYOTA , OGURA TAKAFUMI , FUJITA SHOGO , MURAYAMA HIDEAKI , YAMATOGI TOSHIO , INOUE TOSHIYUKI , HAYASHI KAZUYA , TAKAHARA MAI , GOTO KENTARO , FURUKAWA KOTARO
Published: December 2023

Recently, marine propellers made of carbon fiber reinforced plastics (CFRP) have been put into practical use for merchant ships. CFRP have advantages of high specific stiffness/strength and vibration damping property, and these can reduce the weight and noise of propellers to increase the efficiency and comfort in operation. However, they are more susceptible to impact or cavitation that cause critical damage than conventional propellers made of a copper alloy. Therefore, it can improve the reliability of CFRP propellers to assess the structural integrity based on structural health monitoring (SHM). In this study, piezoelectric line sensors were embedded into intact and damaged blades, respectively, in CFRP propellers with which a leisure boat was equipped. We could successfully detect vibration deformation of the propellers during the boat was moving, and we found that the amplitudes of the measured signals in the damaged blades were larger than those in the intact ones. Consequently, we can say that the applicability of the embedded piezoelectric sensors to SHMsystem for marine propellers is shown and it will increase the reliability not only of the propellers but also of the ship operation in the sea.
Drug Breakdown: Colchicine
Authors: Rees Sharon
Published: December 2023

In this column, Sharon Rees aims to refresh knowledge and interest in some of the commonly used drugs in a series of tweets. This month she is talking about #colchicine
The current state of paediatric non-medical prescribing
Authors: Davies Kate
Published: December 2023

Prescribing for children and young people highlights many complex issues that may not be relevant in other fields of non-medical prescribing. Ongoing changes to legislation pose challenges, requiring paediatric non-medical prescribers to be vigilant in their daily prescribing practice. This article aims to address pertinent challenges and barriers frequently seen in prescribing for children and young people, including not only organisational and human factors, but also legal issues, controversial prescribing, education, the impact of the recent Covid-19 pandemic, and how that has influenced the rise in childhood obesity, in itself an important element.
Fairbairn’s psychology of dynamic structure: a psycho-social approach to dementia II
Authors: Larkins David Michael
Published: December 2023

I will give a detailed description of how Fairbairn’s (1952) model can be used to understand the symptoms of dementia as described by other researchers in particular the concepts of wandering and withdrawal. This will show how Fairbairn’s theory can be related to the experience of those with dementia.
(Un)Doing performative decolonisation in the global development ‘imaginaries’ of academia
Authors: _ _
Published: December 2023

In Western academic spaces, more and more stakeholders are claiming commitments to ‘decolonisation’. Yet in environments shaped by rankings, impact factors, citation numbers and third-party funding figures, what claims to be decolonial scholarship can easily end up being as extractive and violent as the subject it is claiming to confront. In this article, we reflect on attempts to decolonise both the discipline and practice of ‘development’, especially with regard to knowledge ‘production’ in this academic disciplinary space. We are doing this from a particular situatedness that is itself contradictory, as we are both facilitators of an EU-funded network focused on ‘Decolonising Development’ and of Convivial Thinking, a non-institutional, transnational web-based collective. We argue that imperial forms of knowing and making sense of the world are deeply entrenched in the structures of higher education, both shaping and limiting the ways in which what we call ‘development’ is researched, taught and practised. By reflecting on instances of academic activism and institutional pushback in both aforementioned networks, we show how institutional violence limits scholarly imaginations in ways that make sure academic or dominant knowledge structures are not radically challenged, thereby making claims of decolonisation purely performative. Despite this, we also point to concrete openings in both networks where undoing the entanglements of decolonising narratives, ‘development’ and the imperatives of scholarship – and thereby dismantling the master’s house that sustains it – seems within reach.
Wardrobes, Closets, and Windows: The Architecture of the Privé in the Heptaméron
Authors: Butterworth Emily
Published: December 2023

Abstract: This article explores the ways in which the built environment—wardrobes, closets, and windows—affords opportunities for intimacy in Marguerite de Navarre’s Heptaméron . It is also an exploration of a key sixteenth-century word: privé . Not quite yet the modern “private,” privé designates in the Heptaméron intimacy, familiarity, and apartness, and is the cause of some suspicion among the storytellers when it gives the impression of illegitimacy. The article focuses on the spaces and behaviors that are explicitly qualified as “privés” in order to identify its connotations and implications. The material culture of the privé in the Heptaméron is linked to early sixteenth-century architectural developments in palaces and châteaux, court culture, diplomacy, and secrecy. Displays and performances of privé behavior were a valuable way for monarchs and other powerful elites to express favor. Courtly attitudes are echoed by the storytellers and are evidenced in the stories themselves, many of which take place in great Renaissance houses or châteaux. Awareness of the gendered implications of the privé emerges both from the discussions and the stories in which women have more to lose from public displays of intimacy and familiarity. The article offers an investigation of the material culture of the privé and a discussion of its ideological and gendered freight.
Facétieuse Nomerfide
Authors: Thomine Marie-Claire
Published: December 2023

Abstract: This article proposes an in-depth analysis of the character of Nomerfide, one of the devisants in L’Heptaméron , by examining her from the perspective of facetiousness. She is shown at the heart of the narrative device of conversion of tears into laughter, specific to this book, which gives this character a very special place even though she is the youngest and the most playful of the devisants . Nomerfide is analyzed first of all as a storyteller whose stories are distinguished by their brevity and their playful dimension, which must be interpreted in the light of the awareness of the ephemeral character of all things. Endowed with great talents as a storyteller, Nomerfide deploys a vast palette of narrative strategies and comic effects because she wants to fight melancholy and make the good company gathered in Sarrance laugh. On the other hand, Nomerfide does not hesitate to quarrel with the male devisants or to make her voice heard on male violence and on hypocrisy in relationships between men and women. She also openly endorses female desire and pleasure and defends marriages based on love matches. The article shows that Nomerfide, although facetious because she embodies spontaneity, sincerity and naturalness, is also capable of profound words, including religious ones, thus embodying the liberating power of speech.
How the Heptaméron Became Erotica
Authors: Francis Scott
Published: December 2023

Abstract: This article examines a distinct trend in illustrated editions of the Heptaméron , which date back to 1698 but become increasingly common starting in the 1860s. Whereas illustrated Heptamérons from the second half of the nineteenth century tend to foreground displays of passion in the nouvelles and foster a nostalgic vision of France’s medieval past, around the turn of the twentieth century, they go in a direction that specialists of Marguerite might find surprising. The collection could not be considered pornographic or even obscene by today’s standards or those of its time, and if Marguerite foregrounds erotic desire, it is because it is an indelible part of the postlapsarian human condition. However, erotic desire becomes an end in and of itself in illustrated Heptamérons beginning with the fin de siècle . From this point on, the majority of illustrated Heptamérons may be classified as erotica: material designed to provide sexual stimulation but accompanied by more or less lofty artistic ambitions and marketed to wealthy men with bibliophilic inclinations. In other words, there exists alongside the tradition of scholarly editions of the Heptaméron a tradition in which the collection essentially becomes high-class pornography. I will consider what these illustrated editions teach us about erotica in the late nineteenth and early twentieth centuries, as well as about how Marguerite’s magnum opus has been understood and received outside of academia.
In the Defense of Punks and Monsters: Julia Ducournau and Titane
Authors: Bacholle Michèle
Published: December 2023

Abstract: In 2021, Fémis-educated, punk-looking director Julia Ducournau made history when she became the second woman to receive the Palme d'Or for her second film, Titane . A trembling Ducournau thanked the jury for "avoir laissé entrer les monstres." Titane , a cyberpunk/black comedy/fairy tale film, shakes the spectator out of the comfort of mainstream—cisgender, middle-class—culture and cinema and of predictable horror films. This article will first focus on understanding Alexia's character and show that her "monstrosity" is a reaction to the patriarchal order and normative gender roles against which she rebels. We will see how Ducournau stages a "sexual script" outside hetero- and homonormative limits and how she envisions free, fluid love before examining how, using a Christic subtext, albeit in a punk, transgressive manner, she proposes a truly inclusive, caring society.
A low-cost approach to diode-pumped Ti:Sapphire resonators with Watt-level output
Authors: Simpson Niall , Lee Martin , Kemp Alan
Published: December 2023

We report a continuous-wave Ti:sapphire laser with an output power of 1.03 W, achieved with two low-cost single-emitter diode pumps, both of blue wavelength (448 and 468 nm). We reach Watt-level output power using a novel strategy of combining blue-wavelength pumping with a long, low-doping Ti:sapphire crystal, maximising the available pump power while minimising deleterious effects associated with blue pump wavelengths
Improper statistics of radiation from a randomly rotating source.
Authors: Charnotskii Mikhail
Published: December 2023

Abstract: Our earlier work [J. Opt. 19. (2017) 0905603] revealed that, in contrast to the four parameters of the traditional Stokes vector description of the statistics of the partially polarized light, the complete second-order statistics of the narrow-band polarized wave is characterized by thirteen parameters. Here we analyze the second-order statistics of the radiation from a randomly rotating source of the electromagnetic radiation, and show that it includes a covariance of the right and left circular polarizations that is not captured by the Stokes vector formalism. We illustrate this finding with simple examples of rotating quadrupoles and dipole pairs.
From the dilemma of Chinese nation branding and soft power to the performativity of creative power: The TAZARA Memorial Park and artistic intervention in Zambia
Authors: Simbao Ruth
Published: December 2023

In this article I analyse the TAZARA Memorial Park in Zambia, which opened in 2022 and commemorates the Zambians, Tanzanians and Chinese who died while building the TAZARA Railway in the mid-twentieth century. Although the memorial is on Zambian soil and recalls a trinational history, it is largely driven by China as a form of Chinese nation branding and soft power. ‘International friendship’ typical of historic Afro-Asian solidarity permeates the memorial’s narratives, and is expressed through large bronze statues as well as museum dioramas, which have loaded museological histories. Zambia, however, was never a tabula rasa onto which this ‘friendship’ was simply imposed, and contemporary attempts to resuscitate historical solidarity are complex. Through interviews with Zambians who live close to the heritage site or worked on the construction of the railway, I demonstrate that there are multiple Zambian responses ranging from frustration and anger to deep feelings of camaraderie. Moving beyond the language of mainstream international relations, I embrace the performativity and generative creativity of culture itself, developing what I refer to as ‘creative power’. In doing so, I analyse two performative interventions that form part of the series, Tulelosha (‘We are mourning’) (2022–23), and which register the gaps and oversights of the memorial.
2010s Hollywood science fiction: Telling China’s stories well to the world
Authors: Andriano-Moore Stephen
Published: December 2023

Since the founding of the People’s Republic of China, film has been regulated in terms of Mao Zedong’s proclamation that ‘art serves politics’. This article argues that in the 2010s, Hollywood science fiction films serve Chinese politics as nationalistic propaganda and nation branding as part of the soft power initiatives of China’s public diplomacy efforts of ‘going global’ and ‘telling China’s stories well’ in exchange for access to China’s lucrative box office. While most Hollywood films do not include any representations of China, this article identifies a trend in Hollywood science fiction films from the 2010s where entities of China play major roles in the narrative. The article applies narrative and textual analysis to illuminate national image building in five Hollywood films: 2012 (2009), Transformers: Age of Extinction (2014), RoboCop (2014), Arrival (2016) and Pacific Rim: Uprising (2018). These films realize the goal of China’s film policy for positive images of China, such as the world’s leading political and industrial power. The depictions of China are shown to reflect the Made in China 2025 initiative for securing global dominance in technology and manufacturing and links these depictions to the China Dream. The article concludes with a comparative analysis of the Chinese science fiction films Reset (2017) and Shanghai Fortress (2019) and finds that the Hollywood films contain the same national images and narrative roles of China as these domestic films. While this article sheds light on one case of the impact of China on the content of one nation’s films, it is just a small example of the impact of China’s film policy on national cinemas as there are 22 countries with Chinese co-production agreements resulting in over five hundred Sino-foreign co-production revenue-sharing films in the 2010s from countries around the world whose content has been regulated by the Chinese government.
Capitalizing on art and artifying capitals: China’s journey to Venice and scandal around the Kenya Pavilion
Authors: Zhao Xing
Published: December 2023

Embedded in a globalized framework, contemporary Chinese art operates as a powerful network of socio-economic and ideological relationships. Both China and Chinese artists have been assimilated into the global art system, which is firmly built on the basis of capitalism. The world saw a surge in artistic activism in the years between 2008 and 2014, with biennales emerging as the gravitational field in which left-wing theories critically addressed economic and cultural exploitation, as well as the disparities arising from the global capitalist system. While western discourses on contemporary art rejected complicity with the neo-liberal order, refusing to be reduced to ‘a consumable sign of opposition’, the Chinese artworld still upheld neo-liberal values at the Venice Biennale. The incidents involving Chinese artists ‘renting’ the Kenya Pavilion and representing Kenya for the 55th and 56th Venice Biennales in 2013 and 2015 became viral media sensations, prompting accusations of ‘neo-liberalism’ and ‘neo-colonialism’. This article takes the Venetian farce, with a focus on the Kenya Pavilion, as the point of departure to investigate the fame-driven image of China.
The Oeuvre of R. Wagner in Boris Poplavsky’s Creative Reception
Authors: Tyryshkina Elena Viktorovna , Mamatov Gleb Maksimovich
Published: December 2023

The paper is a study of how the heritage of composer, philosopher and opera reformer Richard Wagner is perceived in the works by poet Boris Poplavsky. The poet appeals to Wagner and symbolists in what he refers to as the integrity of all the elements of being in the World Symphony (Wagner’s concept of Gesamtkunstwerk). Symbolists highly valued the vital theurgic force of music, connected with transformation and creation. Poplavsky embraces the concept of the World Symphony and the idea of the integrating power of music, but in his understanding of the nature of this unity, he is far from being traditionalist. He views the fusion of the heterogeneous elements of being through the prism of the congenial phenomenological theory of music-time, emerging in chaos and perpetually vanishing in the depths of a certain transcendental force he named The Absolute. Poplavsky is a transitional figure in the history of the Russian culture. On the one hand, the poet proves to be a successor to the ideas of Richard Wagner and the Russian symbolists, and on the other hand, his ideas of music-time are related to the spirit of the western European philosophy of the 1920‒1930-ies.
Exiled Participants of the January Insurrection in Altai (1863-1864)
Authors: Nikulina I.N. , Серак Елена Владимировна
Published: December 2023

The topic of the Siberian exile of the participants of the January Insurrection (1863-1864) is one of the most important and complex, occupying a special place both in Russian history and in the history of neighboring countries. The relevance of this problem is determined by the importance of this event, which had a great impact on the formation of Russian-Polish relations in the 19th century, the need for a detailed study of the life of the participants of the insurrection in Siberian exile. Extremely difficult interstate relations in the modern world cause an acute need to address the historical experience of cohabitation and interaction of exiles of different nationalities who found themselves in Siberian conditions in the second half of the 19th century. In this regard, there is a need for further in-depth study of the living conditions of exiles in Siberia, their relationship with the administration and the local population. The article deals with the period of stay in Altai of the participants of the January Insurrection (1863-1864), exiled from Mogilev, Minsk, Vitebsk, Grodno provinces. Based on the available sources, the work reflects the issues of the number, places of accommodation, material situation, activities of the exiles, supplemented with details of their biography. Some of the exiles served as scribes, accountants, engaged in education, crafts, beekeeping, having a significant impact on the development of the local population. In the process of direct communication in the conditions of living in Altai, interethnic relations and contacts between the exiles were formed.
War in Mali: Destruction of Timbuktu Monuments
Authors: Filippov V.R.
Published: December 2023

The historical and cultural heritage of the region contains a powerful potential for its preservation and development. The more vividly colored the cultural specificity of the region, more precisely, the cultural peculiarity (and isolation) of the people living in the territory of this region, the greater the historical depth of the cultural tradition that determines the specifics of the population of the region, the more stable the local subculture (in this context, the totality of people having common features of culture and corresponding identity), the more cohesive, more stable the social group. The destruction of the historical cultural heritage, the discrediting of culture, the destruction of the cultural symbols of a particular social community inevitably entails the blurring of its boundaries, the destruction of stable social ties, and the loss of collectively shared values. During the armed confrontation between government troops and jihadist gangs in the Republic of Mali, jihadists captured the ancient cultural capital of the Sahel, the city of Timbuktu. Islamists destroyed ancient mosques and mausoleums, burned ancient manuscripts and libraries in which they were stored. It was an attempt to prevent the formation of a single national community and to prevent the creation of a multicultural nation-state.
National Policy and the Process of National-Territorial Delimitation of Turkestan (1918-1925)
Authors: Tsyryapkina Yu.N.
Published: December 2023

The article analyzes the particular aspects of national policy in Turkestan ASSR in early Soviet period. It is shown that based on the thesis of the RSDLP «the right of nations to self-determination» and the «Declaration of the Rights of the Nations of Russia» in the Turkestan ASSR since 1919-1920, the regular realization of national policy through various methods and mechanisms started: the selection of sections on ethnic groups in the Commissariat for national affairs, the realization of cultural and educational activities of ethnic minorities in their native language, the organization of literacy courses in their native language and documentation in the language characteristic of the most of the population of the region inside Turkestan, the realization of the process of territorial redistriction of okrugs in according to the «national» structure since 1920. It is shown that national delimitation was one of the ways to contend with pan-Turkist moods and the Basmach movement. It is proved that in 1924 the compromise was made between the national and economic principle of the allocation of republics inside Turkestan. In 1925 the national-territorial delimitation of the region was realized on the basis of these principles.
EFFECTIVE PROGRAMS IN THE REHABILITATION TREATMENT OF CHILDREN WITH POSTURE DISORDERS AGAINST THE BACKGROUND OF HEREDITARY CHANGES IN THE DEVELOPMENT OF CONNECTIVE TISSUE IN THE CITY CHILDREN'S POLYCLINIC
Authors:   Altai State Medical University, A. Metalnikov , E. Romanova ,   Altai State University, G. Denisova ,   Altai State University
Published: December 2023

The purpose of the study. To show the importance of effective programs in the rehabilitation treatment of children with posture disorders against the background of hereditary disorders of connective tissue development in the conditions of the city children's polyclinic. 60 patients took part in the research work. All were diagnosed with hereditary disorders of connective tissue development. 30 patients were included in the main group and 30 in the comparison group.Under observation were 30 healthy children who made up the control group. According to gender and age, patients in groups were distributed equally. Patients were dynamically observed on the basis of the city children's polyclinic in the period from 2013 to the present. At the time of the beginning of dispensary observation, the average age of patients was 5.5±0.46 years. In dynamic observation in patients of the main group, laboratory parameters were positively stabilized. In the future, the number of complications decreased by the age of 14. These are scoliosis, kyphosis, other pathological deformities of the spinal column, osteochondropathy of the spine, the development of early osteochondrosis. This was not observed in patients of the comparison group (p = 0.024).
DEVELOPMENT OF A KIWI, CUCUMBER AND GREEN APPLE DRINK
Authors:   Institute of Food Preservation and Quality, Agricultural Academy, P. Ivanova , T. Petrova ,   Institute of Food Preservation and Quality, Agricultural Academy
Published: December 2023

The raw materials Kiwi, Cucumber and Green apple “Granny Smith” were studied in order to optimize the composition of a multi-component juice, through the methodology of design of response surface based on their sensory and quality characteristics. Model test samples of mono-component, two-component and multi-component drinks from the listed raw materials were developed by cold pressing. Characterization of the developed test samples was carried out on the basis of the physicochemical, sensory and spectral tests carried out on the day of their receipt.As a result of the obtained mathematical models for the content of total polyphenols, antioxidant capacity, evaluated by determining the radical scavenging ability (DPPH-test) and sensory evaluation, the composition of developed test samples of drinks based on fruits and vegetables was optimized, the following composition is recommended: drink from kiwi — from 0 to 50 % or from 75 to 100 %,cucumber — from 0 to 15 % and green apple “Granny Smith” — from 25 to 100 %.
AUTOMATED START-UP SYSTEM FOR ATHLETES AND CONTROL AT TRAINING AND COMPETITIONS
Authors:   Moscow Institute of Electronic Technology, V. Korolev , O. Zhoraeva ,   Moscow Institute of Electronic Technology
Published: December 2023

This paper is about developing a time event system at competitions with the athletes and the start-finish identification. To implement the system, widely used integrated systems-on-achip or modules are used, which are a microcontroller with a digital transceiver, accelerometers, gyroscopes and other integrated or external microdevices and sensors, for example, an oximeter, breath sensor, galvanic skin response and others, which are connected to analog -digital converter of the controller or digital port.
DIGITAL TECHNOLOGIES IN IMPROVING THE EFFICIENCY OF TRAINING YOUNG PLAYERS ON THE EXAMPLE OF IMPLEMENTATION ELECTRONIC WORKBOOK (ERT)
Authors:   Ural State University of Physical Culture, P. Kryzhevskikh , N. Mishchenko ,   Ural State University of Physical Culture
Published: December 2023

The theoretical and methodological foundations of the design and introduction of an electronic workbook in the educational and training process of young players, as one of the educational and disabilities of training, are considered. The value of the use of an electronic workbook in the educational and training process of young football players is shown. The structural components are identified and examples of tasks from the electronic workbook in the discipline “Football” are presented. The results of the questionnaire survey of young players are 8–9 years old, aimed at identifying interest in the performance of the proposed tasks of an electronic workbook. A comparative analysis of the showers characterizing the level of achievement of educational results in the implementation of the tasks of the “Football” discipline at the end of the experiment (in points on a 12‑point score of assessment) is given.The ability to include in the content of the Electronic Working Notebook of the Young Football player we have developed in the contents of the modern presentation of information, interactive training programs, new means of monitoring knowledge for verification and self -testing contributes to an increase in educational results to the “optimal level” and performing all the proposed tasks by 8 % of young players experimental group.
Non-Mass-Forming Myeloid Sarcoma of the Colon Presenting With Diarrhea
Authors: Elsharawi Ibrahim , Williams Stacey , Stueck Ashley
Published: December 2023

A female patient in her mid-70s, with a history of diverticulosis, presented with a 2-month history of severe diarrhea, left lower quadrant abdominal pain, decreased appetite, and fever. She was treated for diverticulitis, but did not improve. Subsequent workup revealed leukocytosis and circulating myeloblasts on a peripheral blood smear. Bone marrow evaluation and flow cytometry confirmed the diagnosis of acute myeloid leukemia. Abdominal computed tomography and sigmoidoscopy were performed for her persistent diarrhea. While both failed to show an obvious mass or anatomical abnormality, pathology from the colorectum showed infiltration by leukemic cells consistent with myeloid sarcoma. The diarrhea improved with acute myeloid leukemia chemotherapy.
Clip Dislodgement After Full-Thickness Endoscopic Resection Device Removal of Scarred Gastric Subepithelial Lesion Leading to Delayed Perforation
Authors: Johnson Peter C. , Agnihotri Abhishek , Loren David E. , Kowalski Thomas E. , Schlachterman Alexander , Kamal Faisal , Kumar Anand
Published: December 2023

Endoscopic full-thickness resection using a full-thickness resection device is a newer technique for endoscopic removal of submucosal lesions not amenable to endoscopic mucosal resection or endoscopic submucosal dissection. There is a low rate of complications reported, although we report 2 cases of delayed perforation caused by dislodgement of a full-thickness resection device clip after removal of scarred gastric lesions. Both were managed endoscopically with good outcomes. However, special attention and consideration of alternative closure techniques should be considered with scarred gastric lesions and possible changes to the clip design could be considered.
Unraveling the Gender Gap: A Comparative Analysis of School Enrollment and Secondary Education Completion in Pakistan's Provinces
Authors: REHMAN Nadia , ANDLEEB Irum , IQBAL Mussarat
Published: December 2023

This study examines the gender gap in school enrollment and secondary school completion in Pakistan using secondary data from the Pakistan Social and Living Standards Measurement Survey (PSLM) and Pakistan Education Statistics reports. A comparative analysis of the four provinces and their districts is conducted to identify regional dynamics contributing to gender disparities in education. The research investigates the relationship between students who ever attended school, those who passed secondary school, and the gender gap in enrollment. Descriptive statistics analyze school enrollment rates and dropouts across different regions. Data from the official governmental reports, including the Pakistan Bureau of Statistics and PSLM (2019-20), and education statistics reports from 2017 for Punjab, Sindh, Khyber Pakhtunkhwa, and Balochistan, serve as the foundation for this analysis. The study offers valuable insights into the complex web of causality and influence shaping the persistence of gender disparities in education in Pakistan.