bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of potential inhibitors from Andrographis paniculata bioactive compounds against extended-spectrum β-lactamases through in silico and in vitro approaches
Authors: Moirangthem Anupama , Baruah Taranga Jyoti , Maurya Anand Prakash , Patar Abani Kumar , Paul Susmita , Ingti Birson
Published: December 2023

The present study aims to identify potential medicinal plant-based extended-spectrum β-lactamase (ESBL) inhibitors from Andrographis paniculata using both in silico and in vitro approaches. The ESBLs were obtained from the protein data bank. The structures of phytoconstituents were obtained from the PubChem database. The compounds were docked against different ESBLs (targeted proteins) using AutodockTools followed by molecular dynamics simulation. In silico results were further validated using in vitro testing through the disc diffusion method. The molecular docking revealed that most of the phytoconstituents have a good binding affinity. The binding energy and in vitro study of the phytoconstituents of Andrographis paniculata were compared with the standard inhibitor for ESBL i.e. clavulanic acid .14- Acetylandrographolide (AAD) showed good binding with the ESBL proteins, having the best values reported in the docking with OXA-10. Simulation of the complex of AAD and OXA-10 showed that the complex was relatively steady as evidenced by the lack of sudden fluctuations in the values of root mean square deviations, the radius of gyration and solvent-accessible surface area. Further confirmation of the in silico approach was done by an in vitro study against ESBL-producing organisms which showed inhibitory results. From this study, we can conclude that A.paniculata may have the potential to inhibit ESBLs and may be considered for treating bacterial infections.
Immunomodulatory potential of aqueous extract of Solanum xanthocarpum with reference to splenocyte proliferation and cytokines induction in Wistar albino rats
Authors: Choudhary Pradeep , Khandelwal Vishal
Published: December 2023

Limited study has been done so far to investigate immunomodulatory efficacy of whole plant of hot aqueous extract of Solanum xanthocarpum (HAESX) in Wistar albino rats. Present work has been designed to study immunomodulatory effect of HAESX in Wistar albino rat with respect to splenocyte proliferation and cytokines induction. Concanavalin A (Con A) activated splenocytes were used to measure in vitro cell mediated immune response using 3-(4, 5-Dimethylthiazolyl)-2, 5-diphenyl tetrazolium bromide (MTT) in the presence of varied doses of HAESX (20-500 μg/mL). The effects of HAESX on cell mediated immune response were studied using six groups of Wistar albino rats. Tumor necrosis factor-α (TNF-α), Interferon-γ (IFN-γ), Interleukin-10 (IL-10) and Interleukin-4 (IL-4) were measured in splenocyte culture supernatant by sandwich ELISA with different concentrations of HAESX (20-500 μg/mL). Study depicts significant decrease (p<0.05) in the proliferation of Con A treated splenocyte at 250 and 500 μg/mL HAESX, reflecting cell mediated immunoinhibitory potential of HAESX. Dose dependent significant increase (p<0.01) in the amount of IL-10 was found in splenocyte culture supernatant with increase in HAESX concentrations. TNF-α, IFN-γ and IL-4 were found to decrease significantly (p<0.01) with increase in HAESX concentrations. Study revealed that HAESX of Solanum xanthocarpum is found to influence the networking of cytokines, implying that it may play a function in regulating the activity of the host's immune system and can serve as potent herbal drug against immune rejection.
Facile Preparation and Characterization of Alginate and Triton X-100 Zinc Phosphate modified Surface Nanocrystals as a Novel Anti-corrosive and Antibacterial agent
Authors: Mohammadkhani Arezoo , Seyed Sadjadi Mirabdullah , Farhadyar Nazanin , Mohammadkhani Faezeh
Published: December 2023

In this study, two surface-modified antibacterial and anti-corrosive nanoparticles (ZnP-T, ZnP-ALG) were synthesized by facile and efficient one-step ultrasonic synthesis method. Nanocrystals were characterized by X-ray Diffraction (XRD), Fourier Transform Infrared (FT-IR), Energy Dispersive X-Ray Analysis (EDX), Scanning Electron Microscopy (SEM) and Transmission electron microscopy (TEM). The TEM image showed that the product had good dispersion with a particle size of 10-23, 15–32 nm respectively. Antibacterial and cytocompatibility properties were studied by agar diffusion, in vitro viability and cytotoxicity assay (MTT) and colony-forming-unit (CFU). Antibacterial rate of the ZnP-T and ZnP-ALG nanoparticles reached near 100% and cell viability was near 100%. The corrosion resistance of ZnP-T and ZnP-ALG was evaluated by the electrochemical impedance spectroscopy (EIS) approach. Nyquist diagrams demonstrated that the ZnP-ALG sample had better protection than the ZnP-T sample at all immersion time . The frequency phase angle of the ZnP-ALG sample (θ10 kHz) has a greater value compared with the ZnP-T case.
Developing and Evaluating a Weaned Piglet Model of Enterotoxigenic Escherichia Coli Infection
Authors:   Kyoto Institute of Nutrition & Pathology, Ujitawara, Kyoto, Japan, T Tsukahara , T Matsui ,   Advanced Technology Research Laboratories, Idemitsu Kosan Co. Ltd., Sodegaura, Chiba, Japan, K Sawada ,   Advanced Technology Research Laboratories, Idemitsu Kosan Co. Ltd., Sodegaura, Chiba, Japan, N Nakamura ,   Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Ehime, Japan, T Imaoka ,   KYODOKEN Institute, Fushimi, Kyoto, Japan, N Nakanishi ,   KYODOKEN Institute, Fushimi, Kyoto, Japan, T Sato ,   Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan, T Hamabata ,   Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan
Published: December 2023

Enterotoxigenic Escherichia Coli (ETEC) remains the main pathogen associated with post-weaning diarrhea in piglets. Here, we introduce a reliable method to develop an ETEC-infected weaned piglet model. For the first 24 h post-birth, neonatal piglets were separated from dams so that they did not receive colostrum. Afterwards, piglets were returned to the care of their mothers, until weaning (21-day-old). On days 25, 26 and 27 post-birth, piglets were orally challenged with 1011 Colony-Forming Units (CFU) of virulent ETEC strain incubated in colony-forming antigen medium and delivered in chitosan-coated capsules. In all infected piglets, severe diarrhea and typical body weight loss were observed post-infection. To simplify the work, for the newly developed method, the number of challenging ETEC cells was lowered to 1010 CFU/head and the incubation medium was changed to tryptic soy. These modifications influenced neither the diarrheal defecation ratio nor the body weight loss in piglets. To induce experimentally ETEC infection in future work, we recommend that 1010 CFU/head of ETEC cell grown in tryptic soy broth be delivered in chitosan-coated capsules to colostrum restricted piglets, because this methodology stably caused 100% diarrheal defecation and growth reduction.
Can Plasma miR-122-5p and miR-142-5p Predict Relapse in Metastatic Colorectal Cancer Patients?
Authors:   Institute of Experimental Medicine of Czech Academy of Sciences, Czech Republic, K Cervena , O Kubecek ,   Department of Oncology and Radiotherapy, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic, V Novosadova ,   Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Czech Republic, P Ryska ,   Department of Radiology, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic, J Petera ,   Department of Oncology and Radiotherapy, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic, V Vymetalkova ,   Institute of Experimental Medicine of Czech Academy of Sciences, Czech Republic
Published: December 2023

Approximately 20% of colorectal cancer patients already suffer from metastases at the time of diagnosis. Perhaps more serious, about 50% of the patients with localized tumours will eventually develop metastases during the course of their disease. A current hypothesis suggests that acquired or intrinsic chemoresistance is one of the major causes of metastasis. Recently, we found that circulating miR-122-5p and miR-142-5p could be used to predict both patient outcome and response to therapy. In the present study, we validate our previous results in patients with metastatic colorectal cancer (n=18), taking blood samples at three different times; i.e. metastasis resection surgery (T0), ~1 month after surgery (T1), and~8 months after surgery (T2). The expression levels of miR-122-5p and miR-142-5p were analysed in plasma and plasma extracellular vesicles (EVs) through RT-qPCR. The obtained results were compared against serum CEA and CA 19-9 levels, and computed tomography scans. The rectal cancer patients in the good prognostic group showed significantly increased miR-142-5p expression profile between T1 and T2; whereas the poor prognostic group showed a lower expression during T2 when compared with T1. The decreased expression of miR-142-5p in the latter group could also be seen in the EVs of the patients. This is consistent with our previous study, where the downregulation of miR-142-5p could be associated with poor response to therapy. In addition, the individual analyses showed that the downregulation of both miRNAs predicted tumour relapse at an earlier time point than the markers CEA and CA 19-9. In conclusion, the obtained data from this study demonstrates that miR-142-5p and miR-122-5p could be used as predictive bio-markers of tumour relapse in cases of metastatic rectal cancer, although further validation is still needed.
Current Insights in The Barrier of Continuing Education for General Practitioners in China and Construction of A Novel Raining Model
Authors:   Pingshan hospital of Southern Medical University, Shenzhen, China, Zhou Zhiheng , He Jinghua ,   Orange county American High School of Shenzhen, Shenzhen, China, Zhou Shenqing ,   Pingshan hospital of Southern Medical University, Shenzhen, China, Chen Xianhui ,   Pingshan hospital of Southern Medical University, Shenzhen, China, Zhang Yang ,   Pingshan hospital of Southern Medical University, Shenzhen, China, Wang Shuangxi ,   Pingshan hospital of Southern Medical University, Shenzhen, China, Deng Jiangzhong ,   Pingshan hospital of Southern Medical University, Shenzhen, China, Wu Jiang ,   Pingshan hospital of Southern Medical University, Shenzhen, China, Feng Tianyuan ,   Pingshan hospital of Southern Medical University, Shenzhen, China, Wang Jiaji ,   Pingshan hospital of Southern Medical University, Shenzhen, China
Published: December 2023

Since 1997, China has been carrying out general practice education and has promulgated and implemented the “General Practitioner System”, conducting general practice job transfer training and “5+3” standardized training. However, the continuing education of general practitioners in China was the weakest. This study looked insights in the barrier of continuing education for General Practitioners in China: There was no unified mode and standard for continuing education for general practitioners, lacked of management system covering the entire practice cycle of general practitioners, the focus of post graduation training was unclear, the overall level of the teaching staff was not high, and the enthusiasm of general practitioners to participate in continuing education was poor. In response to these issues, the authors constructed and implemented a full cycle general practitioner continuing education model guided by job competence. Based on summarizing the 10 core job competencies of general practitioners, they constructed a general practitioner training faculty, established general practitioner related systems (continuing education system, practice management system, and professional title promotion system), designed training courses, and conducted hierarchical training, We organized multi-path scientific research training and conducted comprehensive quality management for the continuing education of general practitioners, achieving satisfactory results. Our raining model provided a useful reference for the current continuing education of general practitioners in China and is worth promoting and applying.
Self-employed and parallel import project as options for resolving social and economic problems
Authors: Makhalina O. M. , Makhalin V. N.
Published: December 2023

The article briefly presents an overview of the recent situation in socio-economic sphere. The study analyzes causes and factors of citizens’ informal employment level growth, considers content of self-employment, existing realities, and emerging trends in labor market, and performs a comparative analysis of features of the choice between self-employment and individual entrepreneurship. The essence of parallel imports has been revealed, mechanism of its realization in the existing conditions of legal and economic restrictions considered, positive and negative consequences of its impact on the socio-economic development of Russia investigated. Main conclusions and provisions have been formulated, containing probable direction of the regulatory authorities’ activity, which should allow to realize to the fullest extent the potential of population employment growth embedded in self-employment of citizens through their involvement in the parallel import mechanism.
Comparative analysis of labor productivity factors of personnel of medical organizations providing care to patients with cardiovascular diseases
Authors: Popsuyko A. N. , Morozova E. A. , Artamonova G. V.
Published: December 2023

The issues of improving efficiency of health care institutions are increasingly becoming the center of scientific discussions. The purpose of the study is to examine the subjective assessments of medical organizations staff regarding factors of labor productivity. Objectives of the study: to analyze the existing approaches to the study of labor productivity factors of medical personnel, to study the opinion of medical organizations staff regarding labor productivity factors, to identify the most significant of them, and to conduct a comparative analysis of the data obtained in the course of sociological research in medical organizations providing medical care to patients with cardiovascular diseases in the Kemerovo Region – Kuzbass. The authors have studied the conclusions and findings of selected foreign and domestic experts in this field of research. The presented study identifies the key factors that can increase labor productivity of all categories of personnel on the example of two medical institutions providing care to patients with cardiovascular diseases, namely: presence of a system of material (non-material) incentives, level of material and technical support, moral and psychological climate, working conditions, and regular professional development. Common and special features of two organizations have been shown. Differences in assessing labor productivity factors in different professional categories have been found. The results obtained can be used as a basis for improving personnel policy in direction of increasing labor productivity in health care and medical science institutions.
Determining university’s readiness to implement AI technologies for personalizing educational paths
Authors: Starostin V. S. , Arzhanova K. A. , Dolgopolov D. V. , Ditrikh A. D.
Published: December 2023

The key issue of the article is to determine readiness of HEIs to implement artificial intelligence and machine learning technologies for personalization of students’ individual educational trajectories (hereinafter – IET). In case of compliance of HEIs with the proposed groups of factors, including developed information architecture, there is an opportunity to use multidimensional structured and unstructured data more technologically to improve various types of university activities. High-tech marketing analytical tools facilitate the collection of contextual data and insights into various processes within university, as well as in-depth analysis of learners’ digital footprints. Methods of machine learning, predictive analytics, and modern generative neural networks allow to create recommendation services, with the help of which individual educational trajectories are formed by machine intelligence, simultaneously considering hundreds of parameters. Beyond the tasks of IET formation, machine intelligence can successfully solve tasks for other stakeholders of the university such as professors, researchers, and administration.
Linguistic and communication application aspects of new practical training technologies
Authors: Pokazanyev V. Yu. , Firsova S. V.
Published: December 2023

Project-based learning methodology development and implementation at the State University of Management have contributed to development, coordination, and efficiency of research and students’ project activities. The university has created a concept of project-based learning ecosystem adapted for students and aimed at developing their entrepreneurial abilities. The article emphasizes on the opportunities that the project method offers to improve the content and quality of learning process in higher education institution. The method also helps to increase motivation in learning. Project-based learning is provided in all educational programs. The possibilities of consultations on project-based learning in the Foreign Language course have been considered, the increase of students’ interest in this form of learning activity and foreign language learning in general during the study also have been noted.
Electron Tug Effect in Ni Single Atoms for Carbon Dioxide Electroreduction over a Wide Potential Range
Authors: Han Xu , Zhang Ting , Biset-Peiró Martí , Zhang Chaoyue , Xiao Ke , Cao Pengfei , Heggen Marc , Tang Weiqiang , Vega-Paredes Miquel , Garzón-Manjón Alba , Zheng Lirong , Dunin-Borkowski Rafal E. , Cabot Andreu , Daasbjerg Kim , Morante Joan R. , Arbiol Jordi
Published: December 2023

Atomically dispersed symmetrical NiN4 moieties represent a promising category of catalysts for electrochemical reduction of carbon dioxide (eCO2RR). Nonetheless, their practical application is constrained by challenges such as high overpotentials and limited potential ranges. Here, we report Ni active sites with unique electron distribution realized by minute amounts of Au nanoparticles decoration and lateral oxygen coordination (Au/Ni-N-O-C) for achieving a low overpotential while widening the applied potential ranges. The optimized Au0.5/Ni-N-O-C catalyst exhibits an outstanding eCO2RR performance, achieving over 95% Faradaic efficiency (FE) of CO within a broad potential window from −0.50 to −0.85 V vs. reversible hydrogen electrode, notably, 93% FECO at an overpotential of 340 mV. Theoretical calculations demonstrate that additional electron tug effect on Ni single atoms, induced by the oxygen in the lateral coordination configuration and introduced Au nanoparticles, effectively lower the free energy for *COOH formation by redistributing the electronic distribution of Ni active sites, thus significantly promoting the eCO2RR across a wide applied potential range. This strategy not only presents an efficient pathway to regulate the electron distribution of single atom catalysts, but also is potentially adaptable for diverse catalytic reactions.
Polarized local excitons assist charge dissociation in Y6-based nonfullerene organic solar cells: a nonadiabatic molecular dynamics study
Authors: Liu Bin , Pan ding
Published: December 2023

Y6-based nonfullerene organic solar cells (OSCs) have achieved an outstanding power conversion efficiency (PCE) of over 19% due to the low energy loss and high exciton dissociation efficiency with a small energy offset. However, the exciton dissociation mechanism is still under debate. It is unclear why a small energy offset can lead to efficient exciton dissociation in nonfullerene systems, but causes significant charge recombination in fullerene ones. Most of the previous theoretical studies have focused on the static properties of donor–acceptor heterojunctions, while neglecting excited electron dynamics and nonadiabatic effects. Here, we applied nonadiabatic molecular dynamics simulations to study the charge transfer dynamics in both donor:Y6 and donor:C60 crystalline systems. We found that thermal effects do not significantly influence the exciton dissociation in the NT-4T-FF:Y6 system, which aligns with experimental observations. Based on our simulations, we identified a five-step charge transfer process in nonfullerene systems. While previous studies suggested electrostatic interfacial fields from non-fullerene small molecule acceptors, our research reveals that strong donor-acceptor interactions primarily affect the local exciton states rather than the ground state. Consequently, the polarized local excitons play a key role in reducing the Coulomb attraction between electrons and holes, thus facilitating exciton dissociation with a small energy offset. In contrast, this mechanism is not observed in fullerene OSC systems. Our findings provide a fundamental basis for the further development of novel OSC materials with the potential for achieving even higher PCE.
Exosome-Drug Conjugates Delivery: a Promising Strategy for Improving the Solubility and Bioavailability of Artesunate
Authors: Wang Da , Bai Yunfei , Cheng Guogang , Shen Shengqiang , Xiao Gengwu , Meng Qing , Ma Demei , Zhao Ganggang , Bai Mei , Chen Wei , Li Tianshi , Zhang Litao , Ge Xiaohu
Published: December 2023

Artesunate (ATS) is considered the most widely employed artemisnin derivative in the treatment of Plasmodium falciparum malaria. However, poor solubility and low bioavailability of ATS limit its further clinical application. Herein, we developed a new strategy based on the exosome-drug conjugation (EDC) using the milk-derived exosomes for ATS delivery. The exosome-ATS conjugates (EACs) which formed via a facile bio-conjugation of ATS to the exosomal surface, have been demonstrated to be able to boost the solubility and bioavailability of ATS. Maximal improvement of 71.4-fold in the solubility of ATS was attained using EACs. The corresponding entrapment efficiency and drug loading capacity were found to be 90.3% and 73.9% for EACs, respectively. Further, in vivo pharmacokinetics study manifested that a nearly 5-fold higher peak plasma concentration (Cmax) of ATS than the free ATS was achieved by oral administration of EACs, leading to maximum 2.6-fold improved bioavailability of ATS. Moreover, EACs displayed a distinct sustained-release profile of maximum 36.2-fold prolonged half-life of ATS via intravenous delivery. We reported that for the first time the administration of EACs could be a potential drug delivery strategy for ameliorating the pharmacokinetic profile of ATS based on our encouraging results and hoped that our work opened up a new avenue for the development of EDC delivery system.
Subsystem Density-Functional Theory (Update)
Authors: Jacob Christoph , Neugebauer Johannes
Published: December 2023

The past years since the publication of our review on subsystem density-functional theory (sDFT) [WIREs Comput. Mol. Sci. 2014, 4:325--362] have witnessed a rapid development and diversification of quantum mechanical fragmentation and embedding approaches related to sDFT and frozen-density embedding (FDE). In this follow-up article, we provide an update addressing formal and algorithmic work on FDE/sDFT, novel approximations developed for treating the non-additive kinetic energy in these DFT/DFT hybrid methods, new areas of application and extensions to properties previously not accessible, projection-based techniques as an alternative to solely density-based embedding, progress in wavefunction-in-DFT embedding, new fragmentation strategies in the context of DFT which are technically or conceptually similar to sDFT, and the blurring boundary between advanced DFT/MM and approximate DFT/DFT embedding methods.
Pentapartitioned Neutrosophic Almost Resolvable and Irresolvable Spaces
Authors: R Radha  , A. Stanis Arul Mary
Published: December 2023

The aim of this paper is to develop many characterizations of Pentapartitioned Neutrosophic (PN) almost resolvable and irresolvable spaces and also the condition under that a PN almost resolvable space becomes a PN baire space. The interrelations between PN almost resolvable spaces and other spaces also are mentioned.
Desenvolvimento e validação de aplicativo para auxílio do diagnóstico e gerenciamento clínico das reações, recidivas, reingressos e reinfecções da hanseníase
Authors: Sousa Jéssica Rodrigues de , Loureiro Terezinha Medeiros Gonçalves de , Brasil Alódia , Miquilini Leticia , Cabral André dos Santos
Published: December 2023

O estudo objetivou desenvolver um aplicativo para auxiliar no diagnóstico e no gerenciamento clínico das reações, recidivas, reingressos e reinfecções da hanseníase durante e após o tratamento. Trata-se de um estudo transversal descritivo, de desenvolvimento metodológico com construção e validação de um aplicativo (APP) móvel contendo informações acerca da hanseníase e seu manejo clínico, baseadas em manuais do Ministério da Saúde, para ser utilizado por médicos. O APP foi validado por médicos com experiência em hanseníase, através de uma escala Likert com análise do Coeficiente Alfa de Cronbach e Índice de Validade do Conteúdo (IVC). O APP “Reativação de Sintomas da Hanseníase” foi avaliado por 7 juízes, a maioria com até 10 anos de formado (57%), com maior frequência de mestres (43%) ou especialistas (43%), que atuam em unidades especializadas em hanseníase no Pará, e consideraram o APP interativo, de fácil utilização, útil e com conteúdo confiável. Observou-se alta consistência interna na escala Likert (α=0,81) e elevada proporção de concordância interobservadores (IVC=0,97), sendo considerado válido, configurando um instrumento promissor para aplicação na prática clínica.
New Zealand Association of Scientists 70th Annual Report
Authors: Editors
Published: December 2023

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John Eccles and Karl Popper at the University of Otago, 1945
Authors: Penny David
Published: December 2023

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Ventilasi dan Pencahayaan Rumah Berhubungan dengan Infeksi Saluran Pernapasan Akut (ISPA) pada Balita: Analisis Faktor Lingkungan Fisik
Authors: Rafaditya Salsabela Afifah , Saptanto Agus , Ratnaningrum Kanti
Published: December 2023

Latar Belakang: Infeksi Saluran Pernapasan Akut (ISPA) merupakan salah satu masalah kesehatan pada anak. Lingkungan, individu, dan perilaku merupakan faktor terjadinya ISPA anak. Peneliti ingin melakukan analisis hubungan faktor lingkungan fisik rumah terhadap kejadian ISPA pada balita.Metode: Studi observasional dengan pendekatan cross sectional, teknik penentuan sampel menggunakan consecutive sampling. Penelitian dilakukan di Kelurahan Sokanegara, Purwokerto dengan sampel balita (12-59 bulan) sesuai kriteria inklusi dan eksklusi. Sumber data berasal dari wawancara, pemeriksaan lingkungan fisik dan register Riwayat imunisasi. Analisis menggunakan uji chi-square dan uji regresi logistik.Hasil: Luas ventilasi dan pencahayaan rumah memiliki hubungan yang signifikan terhadap kejadian ISPA pada balita (p=0,019; p=0,049), sedangkan jenis atap, suhu, dan kelembaban tidak berhubungan dengan kejadian ISPA pada balita.Kesimpulan: Luas ventilasi dan pencahayaan rumah berhubungan dengan ISPA pada balita.
Komplikasi Lambat Paska Trakeostomi Dilatasi Perkutaneus dan Intubasi Lama di Unit Perawatan Intensif
Authors: Maryani Nova , Wisudarti Calcarina Fitriani Retno
Published: December 2023

Latar belakang: Percutaneous Dilatation Tracheostomy (PDT) diperkenalkan pada tahun 1985, dikomersilkan di Bergen tahun 1996 dan secara luas digunakan intesivis di Intensive Care Unit (ICU) pada pasien kritis yang membutuhjan ventilasi dalam waktu lama. Prevalensi komplikasi lambat PDT meningkat sekitar 65%. Komplikasi setelah prolonged intubadi seperti granuloma larynx sekitar 44% dan granuloma muncul sekitar 4 minggu setelah ekstubasi sekitar 57%.Kasus: Kami laporkan pasien dengan stenosis trakea dan granuloma paska PDT dan prolonged intubasi sebelum PDT di ICU. Perempuan 24 tahun dengan diagnose dengan edema serebral, kontusio pulmo, fraktur multipel, laserasi hepar dan ginjal kanan, dan sepsis dirawat di ICU. Pasien terintubasi selama 8 hari dan dilakukan dilakukan tindakan PDT dan digunakan selama 25 hari. Satu minggu setelah dekanulasi, pasien mengeluh suara serak dan kesulitan bernafas di rumah. Endoscopy dan CT-scan menunjukkan pasien mengalami stenosis trakea dan granuloma laryng. Kemudian, pasien dijadwalkan untuk dilakukan prosedur reseksi anastomose trakea. Pasien perempuan dengan fraktur multipel dirawat di ICU oleh karena prolonged ET dan sepsis. Pasien intubasi selama 8 hari dan PDT selama 25 hari. Komplikasi muncul setelah 1 minggu dekanulasi. Pasien dengan beberapa faktor risiko berhubungan dengan delayed komplikasi stenosis setelah PDT, termasuk sepsis, infeksi stoma PDT, pergerakan tube PDT yang ekstensif (iritasi mekanik), dan penggunaan lebih dari 8 hari. Indikasi klinis tracheostomy setelah penggunaan intubasi dan menjaga patensi jalan nafas. Ada beberapa pencegahan stenosis trakea yang berhubungan dengan PDT, diantaranya penempatan yang tepat antara cincin 2-3 trakea. Penggunaan bronchoscopy untuk guiding dipertimbangkan sebagai prosedur standar.Kesimpulan: Salah satu komplikasi paska PDT dan prolonged intubasi pada pasien muncul sebagai stenosis trakea dan granuloma laryng. Pasien mengeluh suara serak dan kesulitan bernafas 1 minggu setelah dekanulasi.
Hubungan Shift Kerja dan Sleep Hygiene dengan Kejadian Insomnia pada Perawat RSUD Bumiayu
Authors: Sabila Shelma Assyifa , Widayati Ratih , Setiawan Muhammad Riza
Published: December 2023

Latar Belakang: Insomnia merupakan salah satu dari bahaya akibat pelaksanaan shift kerja dikarenakan tidak sesuainya proses irama sirkadian dengan waktu yang diperlukan oleh seorang pekerja untuk tidur. Sleep hygiene merupakan seperangkat modifikasi dan identifikasi sikap, perilaku, dan lingkungan seseorang yang dapat memberi pengaruh terhadap kualitas tidur. Penerapan perilaku Sleep hygiene yang benar dan baik dapat memberikan kualitas tidur yang baik dan sehat. Penelitian ini bertujuan untuk menganalisis hubungan shift kerja dan sleep hygiene dengan kejadian insomnia pada perawat RSUD Bumiayu.Metode: Penelitian ini merupakan penelitian observasional analitik kuantitatif melalui rancangan cross sectional. Sampel penelitian adalah perawat RSUD Bumiayu, sebanyak 93 orang yang memenuhi kriteria inklusi dan eksklusi. Shift kerja dan sleep hygiene digunakan sebagai variabel bebas dan insomnia sebagai variabel terikat. Proses analisis penelitian ini menggunakan uji chi square.Hasil: Hasil analisis data antara shift kerja dengan insomnia didapatkan p value = 0,282 (p > 0,05), dan analisis data antara sleep hygiene dengan insomnia didapatkan p value = 0,048 (p < 0,05).Kesimpulan: Hasil analisis menunjukkan tidak ada hubungan antara shift kerja dengan kejadian insomnia pada perawat RSUD Bumiayu. Namun, ada hubungan antara sleep hygiene dengan kejadian insomnia pada perawat RSUD Bumiayu.
Proces rewitalizacji dzielnicy na przykładzie Nowego Portu w Gdańsku
Authors: Janicki Mateusz
Published: December 2023

Celem artykułu jest ukazanie procesu rewitalizacji przestrzeni miejskiej. Za wzorcowy przykład posłużyła gdańska dzielnica Nowy Port. Z racji swojego zaniedbania, złej opinii oraz potrzeb inwestycji została ona włączona do miejskiego programu rewitalizacji. Na łamach artykułu przedstawiono podjęte działania, które zostały podzielone na dwie części. Wyodrębniono te dotyczące inwestycji oraz pracy na rzecz lokalnego społeczeństwa. Dwutorowa, równoległa działalność angażująca mieszkańców była niezbędna do osiągnięcia sukcesu całego procesu. Tekst stanowi podsumowanie dotychczas podjętych działań oraz podkreśla potrzebę podejmowania podobnych procesów w innych obszarach miasta.
Aktorzy subpaństwowi jako podmioty dyplomacji
Authors: Rydzewska Agata
Published: December 2023

Celem artykułu jest analiza aktorów subpaństwowych jako podmiotów dyplomacji. W artykule został poruszony problem ewolucji podmiotowej dyplomacji oraz trudności we współczesnym definiowaniu tego pojęcia. Ponadto opisane zostały kwestie dotyczące naukowego dyskursu na temat aktywności zewnętrznej jednostek terytorialnych, tj. problemu z terminologią oraz różnorodnym poziomem zaawansowania. Przedstawiono różne klasyfikacje motywów takiej działalności oraz zobrazowano przykładami instrumenty, którymi się posługują.
Kilka uwag na tle cofnięcia pozwolenia na broń na podstawie art. 18 ust. 1 pkt 2 w zw. z art. 15 ust. 1 pkt 6 ustawy o broni i amunicji
Authors: Maciąg Anna
Published: December 2023

Przedmiotem rozważań w artykule jest jedna, wybrana przesłanka obligatoryjnego cofnięcia pozwolenia na broń – z art. 18 ust. 1 pkt 2 w zw. z art. 15 ust. 1 pkt 6 ustawy z dnia 21 maja 1999 r. o broni i amunicji. Pierwotnie przepis ten skonstruowany był w sposób otwarty, jako że zawierał frazę „w szczególności”. Po nowelizacji tego przepisu w związku z implementacją unijnej dyrektywy (dyrektywa Rady nr 91/477/EWG z dnia 18 czerwca 1991 r.) od 10 marca 2011 r. zmieniono brzmienie art. 15 ust. 1 pkt 6 wspomnianej ustawy. W miejsce wcześniejszego katalogu otwartego wprowadzono precyzyjny zakres stanów faktycznych, które mogą stać się podstawą cofnięcia pozwolenia na broń na podstawie tego przepisu. Osią sporu stało się jednak ustalenie, czy fraza wskazana we wprowadzeniu do wyliczenia przesłanek w tym przepisie, a więc: „stanowiącym zagrożenie dla siebie, porządku lub bezpieczeństwa publicznego” stanowi odrębną przesłankę cofnięcia pozwolenia na broń. Uważam, że dopuszczenie takiej możliwości może negatywnie oddziaływać na sytuację jednostki posiadającej pozwolenie na broń, stąd weryfikuję, czy interpretacja taka (przyznana przez WSA w Warszawie w wyroku z dnia 28 listopada 2013 r., II SA/Wr 1775/13) może być uprawniona i posiadać podstawę w obowiązującym porządku prawnym. Rozważania opieram nie tylko na aspekcie redakcyjnym (językowym) konstrukcji przepisu. Porównuję także historyczne brzmienie przepisu z aktualnym; badam jakość implementacji unijnej dyrektywy i ewentualne skutki dla jednostki błędnej jej implementacji, a także analizuję orzecznictwo oraz doktrynę w tym przedmiocie.
Rola żelazowych szkieletów metaloorganicznych w procesach fotokonwersji dwutlenku węgla
Authors: Zdybel Szymon
Published: December 2023

W niniejszej pracy przedstawione zostały dane dotyczące szkieletów metaloorganicznych (ang. metal-organic frameworks, MOF-y), ze szczegółowym opisem związków należących do grupy żelazowych szkieletów metaloorganicznych (Fe-MOF). Przedstawiona została charakterystyka struktury materiałów wraz z wynikającymi z niej specyficznymi właściwościami, jakie posiadają Fe-MOF-y. Omówione zostały również metody otrzymywania opisywanych związków chemicznych z uwzględnieniem podziału na metody konwencjonalne oraz niekonwencjonalne. W kolejnych częściach artykułu przedstawione zostały techniki wykorzystywane w procesie charakterystyki fizykochemicznej tych materiałów chemicznych, takie jak dyfraktometria rentgenowska, spektroskopia Fouerierowska w podczerwieni, Skaningowa Mikroskopia Elektronowa i inne. W końcowej części zostało przedstawione pojęcie fotoredukcji dwutlenku węgla do bardziej użytecznych produktów, takich jak kwas mrówkowy, metan czy metanol. Proces ten został opisany jako innowacyjne rozwiązanie jednego z najważniejszych problemów cywilizacyjnych, jakim jest krytyczna emisja gazów cieplarnianych, w szczególności CO2, których wynikiem jest globalne ocieplenie klimatu. Zestawione zostały potencjalne korzyści wynikające z wykorzystywania żelazowych szkieletów metaloorganicznych jako fotokatalizatorów, na których powierzchni może zachodzić konwersja zaadsorbowanego dwutlenku węgla pod wpływem promieniowania ultrafioletowego lub widzialnego
Новая ε-полиморфная модификация 4-нитрофенил-замещенного нитронилнитроксила
Authors: Федянин И.В. , Самигуллина А.И. , Третьяков Е.В.
Published: December 2023

Получен и охарактеризован методом монокристальной рентгеновской дифракции новый ε-полиморф 4,4,5,5-тетраметил-2-(4-нитрофенил)-4,5-дигидро-1H-имидазол-3-оксид-1-оксила. В тех же условиях накоплены массивы рентгеноструктурных данных и решены структуры известных α‑γ полиморфных форм этого парамагнетика. Выполнен анализ кристаллических структур полиморфов с использованием качественного и количественного анализа поверхностей Хиршфельда. Показано, что в известных α-δ полиморфах присутствует супрамолекулярный ассоциат — центросимметричный димер, в котором молекулы связаны C-H···O водородными связями. В то же время, только в ε-полиморфе наблюдается образование π-связанных бесконечных стопок нитрофенильных заместителей, обусловливающее, в свою очередь, реализацию коротких расстояний между атомами кислорода нитроксильных групп (3.508(2) и 3.627(2) Å).
Digital Feminism in Indonesia: The Counter-Narratives to Gender Inequality on Instagram
Authors: Daniah Izza Annafisatud , Pribadi Yanwar
Published: December 2023

In the last few years, many people have used cyber religion to identify new forms of religious communities and rituals. It acts as the source of religious engagement that is different, new, creative, and alienated from 'conventional' religions. This article aims to reveal how Mubadalah.id as an Instagram account plays a role in providing beautification of da'wa (Islamic preaching conveyed by Islamic scholars) in countering unjust interpretations of Islamic texts toward women. In particular, it is a representation of Islamic media and women’s rights that strengthens the capacity and authority of women ulama. They are carrying on perspectives that affirm the values ​​of reciprocity, equality, cooperation, and justice in marital, familial, and social relations. Mubadalah.id is a social media campaign affiliated with the Fahmina Foundation, a notable Muslim organization that promotes gender equality in Indonesia. This article is qualitative research. Using a virtual ethnography method, this article aims to understand the strategy used by this account to counter gender inequality narratives. This article argues that Instagram can be optimized to build a moderate gender construction in countering the mainstreaming of patriarchal ideas on social media by supplying alternative interpretations served in beautified content. In addition, this account shows the representation of women's ulama in Indonesian public spaces to negotiate their identity in a Muslim-majority country.
Note on Type L-Functions of Euler Product of Second Degree
Authors: Hakami Ali H.
Published: December 2023

In this paper we are concerned with a special case of Euler functions. We shall study the Euler product of degree two (Type of L-Euler functions) and give some results. More precisely, we shall deal with some Dirichlet series associated with a class of arithmetic {an} under the condition that apapk = apk+1 + pαapk−1, provided p is prime, k≥1, and α is a fixed complex number. We will demonstrate that there is an Euler’s product for the Dirichlet series Σnan/ns. This result is important in analysis, especially in analytic number theory.
TƏKRARLANAN İMPLANTASİYA UĞURSUZLUĞU. KÖK HÜCEYRƏLƏR TƏTBİQİ PRESPEKTİVLƏR
Authors: J.F. Gurbanova  , K.G. Garaeva  , A.S. Hasanova  , A.M. Beyishova  , N.B. Mejidova  , L.Y. Akhmedova
Published: December 2023

Bu məqalədə, endometrial disfunksiyanın səbəb olduğu qadın sonsuzluğunun müalicəsi üçün MSCs mezenximal kök hüceyrələri (MSCs) terapiyasının təsirini araşdıran bir ədəbiyyat araşdırması aparıldı. Mezenximal kök hüceyrələr (MSCs) əla olduğunu göstərdi endometrial disfunksiya nəticəsində yaranan sonsuzluğun müalicəsi üçün potensial. Piy və ya menstrual toxumadan əldə edilən kök hüceyrələrin digər mənbələrdən üstünlüyü var, çünki hüceyrələr asanlıqla əldə edilə bilər və sonra immunoloji greft rəddinə səbəb olmur. Bununla belə, bu istiqamətdə klinik tədqiqatların təşviqinə ehtiyac var.
HAMİLƏ QADINLARDA STOMATOLOJİ GİGİYENİK VƏRDİŞLƏR
Authors: N.K. Karimli  , A.Ch. Pashayev  , Sh.Kh. Qadimova
Published: December 2023

Dölün böyüməsi və ana orqanizminin doğuşa hazırlanması ilə əlaqədar olaraq, hamilə qadınların orqanizmində bir sıra vacib fizioloji proseslər baş verir. Bu dəyişikliklər müxtəlif orqanlarda olduğu kimi, ağız boşluğunda da rast gəlinir. Ağız boşluğununsağlam olması orqanizmin ümumi sağlamlığının tərkib hissəsi olaraq bu prosesdə mühüm rol oynayır.Ona görə də, bütün həyat dövrü ərzində, o cümlədən hamiləlik zamanı ağız boşluğu sağlamlığının qayğısına qalmaq lazımdır. Hamilə qadınlarda ağız boşluğunun sağlam olması həm qadının öz sağlamlığı üçün vacib əhəmiyyət kəsb edir, həm də həmindövrdə baş verə biləcək ağırlaşmaların azalmasına səbəb olur
Geçici kenar koruma sistemleri kullanımının inşaat proje maliyetine etkisi
Authors: AKYÜZ Reşat , KUŞAN Hakan , AYTEKİN Osman
Published: December 2023

Türkiye'de iş kazalarına ilişkin istatistiki veriler incelendiğinde, iş kazaları sonucu meydana gelen ölüm, meslek hastalığı ve sürekli iş göremezlik sayılarında artış olduğu görülmektedir. Tüm sektörler arasında inşaat sektörü, iş kazası sayısı ve ağır sonuçları bakımından diğer sektörlere kıyasla ilk sırada yer almaktadır. Bu çalışmada, İşyeri Tehlike Sınıfları Listesinde NACE kodlarında yer alan 3 başlık altında faaliyet gösteren inşaat sektöründeki işyerlerinde 2020 ve 2021 yıllarında meydana gelen iş kazalarına ilişkin veriler Sosyal Güvenlik Kurumu Hizmet Sunumu Genel Müdürlüğü'nden temin edilerek analiz edilmiştir. İş kazaları sonucu Sosyal Güvenlik Kurumu'na yapılan bildirimler sınıflandırılarak iş kazalarının nedenleri tespit edilmiş ve en çok ölümlü iş kazasının yüksekten düşme nedeniyle gerçekleştiği belirlenmiştir. İnşaat sektöründe ölümlü iş kazalarının en önemli nedeni olan yüksekten düşme kaynaklı iş kazalarının önlenmesi için standartlara uygun geçici kenar koruma sistemlerinin kullanımı ve proje maliyetine etkisi araştırılmıştır.
The digital strategy of the construction organisation and options for its implementation
Authors: Ivanov Nikolay
Published: December 2023

The article discusses ways of implementing the Program for the Development of Digital Economy in the Russian Federation until 2035 adopted five years ago by the Government of the Russian Federation in the construction industry. On the one hand, digital transformation is the most important factor in ensuring the competitiveness of individual construction organizations, and on the other hand, it ensures the effective functioning of the entire industry in the digital economy. However, the existing differences of enterprises and organizations in the construction industry put them in different initial conditions on the way to solving the task, forcing them to form their own version of digital strategy, to choose and implement their own options for its implementation in the dynamically changing conditions of the construction market. As a result of the work, the key features of digitalization strategies of the main groups of construction participants were formulated, and the ways of effective development and implementation of the digital strategy of a construction organization were proposed, taking into account the availability of resources and the level of management development.
Regarding digital photogrammetric processing of aerial photos to create solutions for the construction industry
Authors: Sutugina Irina , Sadovskiy Boris
Published: December 2023

This article examines application of the outcome of digital photogrammetric processing of aerial photos in order to create solutions for the construction industry. The article also considers developing of an orthophotomap and analyses a number of factors that affect the task precision.
Designing a software system to ensure the operation of the spectral acoustic method for dust control in construction
Authors: Rybakova Angelina , Fetter Matvey
Published: December 2023

The article raises the problem of the need to develop specialized functionality of software complexes of information modeling technologies for the development of models of objects of modular buildings in order to minimize manual actions when solving routine tasks. The general concept of the tool is defined, the main functional requirements are formulated and the development of a specialized script is carried out. Based on the initial data in the form of information models of modular elements and basic technical and economic indicators, the construction of a complex information model of a modular object with the possibility of instantaneous adjustment and variable operation is formed in an automated mode. The purpose of this study is to develop a means of automating the construction of a complex information model based on modular elements of maximum readiness, tasks: analysis of the features of modular design, study of the possibilities of visual programming tools and script development.
Creation of intelligent situational centers at construction sites
Authors: Sirotskiy Alexei
Published: December 2023

The article discusses the issues of organizing, creating and deploying situation centers on construction sites as a single point of control and monitoring of objects and processes during the construction of capital construction projects. The key tasks of situation centers are to monitor compliance with work regulations in accordance with schedules and project documentation, as well as ensure that personnel comply with safety regulations. One of the main components of the information and software-algorithmic support of situation centers are artificial intelligence tools and neural network technologies that can classify objects on a construction site, identify trends in the development of events, predict the interaction of objects, determine probabilities and prevent safety violations. Situation centers are semi-stationary objects, the functionality of which must ensure the implementation of a set of monitoring and control tasks at construction sites, and at the same time meet the requirements for transformation and transfer to new construction sites.
Optimization of safety on construction sites with using artificial intelligence to recognize construction equipment
Authors: Garyaev Andrey , Garyaeva Venera
Published: December 2023

The paper explores the application of artificial intelligence (AI) to identify construction equipment using CCTV cameras on construction sites. The main goal is to increase safety levels, optimize construction processes and increase productivity. The research covers the analysis of world and Russian experience in creating neural networks, collecting data on construction equipment and developing an AI model for recognizing and classifying machines based on their visual characteristics. The system was also tested to evaluate its accuracy and efficiency. The article discusses various approaches to training neural networks, including supervised and unsupervised learning, reinforcement learning, transfer learning, generative adversarial networks, convolutional and recurrent neural networks, autoencoders, and hybrid models. Particular attention is paid to integrating AI with other aspects of construction site safety, including alarm systems, emergency response and personnel training. This research proposes a multi-layered approach to construction site safety, ensuring not only accident prevention but also improved work processes. Ultimately, the application of AI on construction sites helps create a safer, more organized and controlled work environment, which is critical for large construction projects.
Experimental studies of the interaction of a cross-beam foundation and an inclined base over a karst cavity
Authors: Evtushenko Sergej , Zelenin Evgeniy
Published: December 2023

The article presents the results of field experiments carried out on the joint work of a cross-beam foundation and an inclined foundation when it is limited by a rigid vertical retaining structure at the time of a sudden collapse of the karst cavity arch. The regularities of the transformation of the sinkhole prism are determined depending on the angle of inclination of the base and the location of the cavity relative to the foundation structure.