bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Ozone with 5‐Fluorouracil and Cisplatin in Regulation of Human Colon Cancer Cell Viability: In Vitro Anti‐Inflammatory Properties of Ozone in Colon Cancer Cells Exposed to Lipopolysaccharides
Authors: Simonetti Vincenzo , Quagliariello Vincenzo , Giustetto Pierangela , Franzini Marianno , Iaffaioli Rosario Vincenzo
Published: July 2017

Introduction. Ozone therapy is an effective medical treatment for different diseases like mucositis, psoriasis, acute pain, neurovascular diseases, and cancer. The aim of this study is based on the association of different ozone concentration with 5‐fluorouracil and cisplatin in human colon cancer cell (HT29 cell line) in order to investigate possible anticancer synergistic effects. Methods. HT29 cells were incubated with ozone at different concentration ranging from 10 up to 50 μg/ml at different incubation time alone or in combination with cisplatin and 5‐fluorouracil. Cell viability was performed by using a modified MTT method. Anti‐inflammatory studies were conducted incubating HT29 with or without 20, 30, or 50 μg/ml of ozone before exposure to lipopolysaccharides. Results. Ozone alone has a time and concentration dependent cytotoxicity against HT29 cells (IC50 at 24 h: 30 μg/ml). Association of ozone with drugs increases cytotoxicity by 15–20%. Preincubation of ozone at 50 μg/ml decreases IL‐8, IL‐6, and IL‐1β production by 50, 56, and 70%, respectively, compared to untreated cells. Conclusion. These results indicated that ozone could be useful in colon cancer management in combination with 5‐fluorouracil and cisplatin with significant inhibition of cytokines having a central role in colon cancer cell survival and chemoresistance.
Cellulose Acetate Based Material with Antibacterial Properties Created by Supercritical Solvent Impregnation
Authors: Milovanovic Stoja , Adamovic Tijana , Aksentijevic Ksenija , Misic Dusan , Ivanovic Jasna , Zizovic Irena
Published: July 2017

Supercritical CO2 was used as a green solvent and impregnation medium for loading cellulose acetate beads with carvacrol in order to obtain a biomaterial with antibacterial properties. Supercritical solvent impregnation was performed in a high-pressure view cell at temperature of 50°C and pressures of 10, 21, and 30 MPa with the processing time ranging from 2 to 18 h. The rate of impregnation increased with the pressure increase. However, maximum impregnation yield (round 60%) was not affected by the pressure applied. Selected samples of the impregnated cellulose acetate containing 6–60% of carvacrol were proven to have considerable antibacterial effect against Gram-positive and Gram-negative bacterial strains including methicillin-resistant Staphylococcus aureus which causes severe infections in humans and animals. In addition, cellulose acetate beads containing 6.0–33.6% of carvacrol were shown to have a porous structure with submicron pores which is of interest for the controlled delivery applications.
Prevalence of the Metabolic Syndrome in Central and South American Immigrant Residents of the Washington, DC, Area
Authors: Gill Regina M. , Khan Saira A. , Jackson Robert T. , Duane Marguerite
Published: July 2017

The objective of this study was to estimate the prevalence of Metabolic Syndrome (MetS) and its risk components and then compare differences in the risk components among low-income, uninsured Central and South American recent immigrants to the USA. This cross-sectional survey sampled 1,042 adult patients from a medical clinic in metropolitan Washington, DC. The overall prevalence of the MetS was 26.9% estimated using the modified harmonized definition. The most common abnormal metabolic indicator for women was an elevated BMI ≥ 30 kg/m2(36.1%), while, for men, it was an elevated triglyceride level (46.5%). The risk of abnormal MetS indicators increased steadily with increasing BMI. The abnormal indicator combination identifying the most subjects with the MetS included the following: high triglycerides, low HDL cholesterol, and obesity. MetS rates were highest among subjects from El Salvador and Honduras, 31.3% and 28.0%, respectively, and lowest among subjects from Bolivia (21.7%). Dyslipidemia and high BMI increased the likelihood of having the MetS, which is consistent with studies on Mexican Americans in the San Antonio Heart Study and studies within Central and South American countries. This study adds new baseline epidemiological data for largely understudied, low-income, and mostly recent immigrant groups.
Determinants of Walking among Middle-Aged and Older Overweight and Obese Adults: Sociodemographic, Health, and Built Environmental Factors
Authors: Forjuoh Samuel N. , Ory Marcia G. , Won Jaewoong , Towne Samuel D. , Wang Suojin , Lee Chanam
Published: July 2017

Background. This study examined the association between selected sociodemographic, health, and built environmental factors and walking behaviors of middle-aged and older overweight/obese adults. Methods. Subjective data were obtained from surveys administered to community-dwelling overweight/obese adults aged ≥50 years residing in four Texas cities from October 2013 to June 2014, along with objective data on neighborhood walkability (Walk Score™). Multivariate logistic regression identified factors predicting the odds of walking the recommended ≥150 minutes per week for any purpose. Results. Of 253 participants, the majority were non-Hispanic white (81.8%), married (74.5%), and male (53.4%) and reported an annual income of ≥$50,000 (65.5%). Approximately, half were employed (49.6%) or had at least a college degree (51.6%). Walking the recommended ≥150 minutes per week for any purpose (n=57, 22.5%) was significantly associated with having at least a college degree (OR=5.55, 95% CI = 1.79–17.25), having no difficulty walking a quarter of a mile (OR=5.18, 95% CI = 1.30–20.83), and being unemployed (OR=3.25, 95% CI = 1.18–8.93) as well as perceived presence of sidewalks/protected walkways (OR=3.56, 95% CI = 1.10–11.50) and perceived absence of distracted drivers in the neighborhood (OR=4.08, 95% CI = 1.47–11.36). Conclusion. Addressing neighborhood conditions related to distracted drivers and pedestrian infrastructure may promote walking among middle-aged and older overweight/obese individuals.
Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors
Authors: Karki Keshav , Hedrick Erik , Kasiappan Ravi , Jin Un-Ho , Safe Stephen
Published: July 2017

Piperlongumine is a natural product found in the plant species Piper longum, and this compound exhibits potent anticancer activity in multiple tumor types and has been characterized as an inducer of reactive oxygen species (ROS). Treatment of Panc1 and L3.6pL pancreatic, A549 lung, 786-O kidney, and SKBR3 breast cancer cell lines with 5 to 15 μmol/L piperlongumine inhibited cell proliferation and induced apoptosis and ROS, and these responses were attenuated after cotreatment with the antioxidant glutathione. Piperlongumine also downregulated expression of Sp1, Sp3, Sp4, and several pro-oncogenic Sp-regulated genes, including cyclin D1, survivin, cMyc, EGFR and hepatocyte growth factor receptor (cMet), and these responses were also attenuated after cotreatment with glutathione. Mechanistic studies in Panc1 cells showed that piperlongumine-induced ROS decreased expression of cMyc via an epigenetic pathway, and this resulted in downregulation of cMyc-regulated miRNAs miR-27a, miR-20a, and miR-17 and induction of the transcriptional repressors ZBTB10 and ZBTB4. These repressors target GC-rich Sp-binding sites to decrease transactivation. This pathway observed for piperlongumine in Panc1 cells has previously been reported for other ROS-inducing anticancer agents and shows that an important underlying mechanism of action of piperlongumine is due to downregulation of Sp1, Sp3, Sp4, and pro-oncogenic Sp-regulated genes. Cancer Prev Res; 10(8); 467–77. ©2017 AACR.
Yoga: Can It Be Integrated with Treatment of Neuropathic Pain
Authors: Telles Shirley , Sayal Natasha , Nacht Carrie , Chopra Abhishek , Patel Kush , Wnuk Alice , Dalvi Priya , Bhatia Kulsajan , Miranpuri Gurwattan , Anand Akshay
Published: July 2017

Background: Neuropathic pain (NP) is a debilitating condition that may result from spinal cord injury (SCI). Nearly 75% of all SCIs result in NP affecting 17,000 new individuals in the United States every year, and an estimated 7-10% of people worldwide. It is caused by damaged or dysfunctional nerve fibers sending aberrant signals to pain centers in the central nervous system causing severe pain that affects daily life and routine. The mechanisms underlying NP are not fully understood, making treatment difficult. Identification of specific molecular pathways that are involved in pain syndromes and finding effective treatments has become a major priority in current SCI research. Yoga has therapeutic applications that may prove beneficial in treating subjects suffering chronically from SCI-induced NP, chronic back and associated pain if necessary experimental data are generated. Summary: This review aims to discuss the implications of various mechanistic approaches of yoga which can be tested by new study designs around various nociceptive molecules including matrix metalloproteinases, cation-dependent chloride transporter (NKCC1), etc. in SCI-induced NP patients. Key Messages: Yogic practices could be used in managing SCI-induced NP pain by regulating the action of various mechanisms and its associated molecules. Modern prescriptive treatment strategies combined with alternative approaches like yoga should be used in rehabilitation centers and clinics in order to ameliorate chronic NP. We recommend practical considerations of careful yoga practice as part of an integrative medicine approach for NP associated with SCI.
Serum Anticytokine Autoantibody Levels Are Not Increased in Hidradenitis Suppurativa: A Case-Control Pilot Study
Authors: Theut Riis Peter , von Stemann Jakob Hjorth , Kjærsgaard Andersen Rune , Hansen Morten Bagge , Jemec Gregor B.E.
Published: July 2017

Background: Hidradenitis suppurativa is a skin disease of recurrent episodes of inflammatory nodules, abscesses, and scarring of the intertriginous regions, e.g. the axillae and groin. A dysregulated immune response to one or more unknown antigens in hidradenitis suppurativa has been suggested. One hypothetical element of this dysregulation may be the functionality of the cytokines. This study examines the serum level of anticytokine autoantibodies for interleukin (IL)-1α, IL-6, IL-10, IL-17A, IL-17E, IL-17F, and interferon-α. Method: Recombinant, carrier-free cytokines were coupled to microspheres. The coupled beads were incubated for 1 h in the dark with assay buffer-diluted sera, and subsequently for 30 min with polyclonal goat F(ab′)2 anti-human IgG phycoerythrin-conjugated antibody. Data are presented as the median fluorescence intensity of samples. Results: No difference in levels of anticytokine autoantibodies was demonstrated for any of the autoantibodies studied. Discussion: The data suggest that endogenously produced autoantibodies only play a minor role, if any, in hidradenitis suppurativa.
The First Frontier: Digital Biomarkers for Neurodegenerative Disorders
Authors: Dorsey E. Ray , Papapetropoulos Spyros , Xiong Mulin , Kieburtz Karl
Published: July 2017

Current measures of neurodegenerative diseases are highly subjective and based on episodic visits. Consequently, drug development decisions rely on sparse, subjective data, which have led to the conduct of large-scale phase 3 trials of drugs that are likely not effective. Such failures are costly, deter future investment, and hinder the development of treatments. Given the lack of reliable physiological biomarkers, digital biomarkers may help to address current shortcomings. Objective, high-frequency data can guide critical decision-making in therapeutic development and allow for a more efficient evaluation of therapies of increasingly common disorders.
Using High-Resolution 3D Magnetic Resonance Imaging to Quantitatively Analyze the Shape of Eyeballs with High Myopia and Provide Assistance for Posterior Scleral Reinforcement
Authors: Wen Baohong , Yang Ge , Cheng Jingliang , Jin Xuemin , Zhang Huixia , Wang Feifei , Yan Chenyu , Zheng Dandan , Xu Tianyong
Published: July 2017

Purpose: To quantitatively analyze the shape of eyes with high myopia and provide assistance for posterior scleral reinforcement (PSR) using high-resolution three-dimensional (3D) magnetic resonance imaging (MRI). Method: In all, 260 eyes of 134 patients with high myopia were assessed in this study; 120 emmetropic volunteers were enrolled as a control group. The subjects were examined using 3D T2-weighted CUBE sequences. Results: The eyeballs' axial, horizontal, and vertical lengths were longer and their volume was larger in the subjects with high myopia than in those with emmetropia. The sites of the four recti and optic nerve attachment to the eye were clearly seen on 3D MRI, and the geometric information could be quantified for PSR preparation. The scleral strip was revealed by 3D MRI after surgery. Conclusions: 3D MRI can quantitatively analyze the shape of eyes with high myopia. 3D MRI examination might be necessary before and after PSR for preoperative preparation and postoperative assessment.
Oncological Outcomes following Rectal Cancer Surgery with High or Low Ligation of the Inferior Mesenteric Artery
Authors: Matsuda Kenji , Yokoyama Shozo , Hotta Tsukasa , Takifuji Katsunari , Watanabe Takashi , Tamura Koichi , Mitani Yasuyuki , Iwamoto Hiromitsu , Mizumoto Yuki , Yamaue Hiroki
Published: July 2017

Background: The level of inferior mesenteric artery (IMA) ligation for anterior resection of rectal cancer has several considerations concerning oncological outcomes. The primary endpoint of this randomized controlled trial (RCT) was to assess bowel function between high and low ligation. This study was intended to clarify oncological outcome as the secondary endpoint. Objective: The aim of this study was to assess in a prospective RCT whether the ligation level of the IMA in rectal cancer influences oncological outcomes. Methods: Between February 2008 and December 2011, 100 patients who underwent anterior resection for rectal cancer were randomized to perform either high or low ligation of the IMA. Oncological outcomes was the secondary endpoint of this RCT, whereas assessing bowel function was the primary endpoint. This RCT was registered at clinicaltrials.gov (NCT00701012). Results: There were no differences between the groups in terms of clinical data except for tumor stage. There were more advanced-stage patients in the high ligation group (p = 0.046). There were no lymph node (LN) metastases in the root of the IMA in the high ligation group. The average number of harvested LNs for the high and low ligation groups was 16.7 and 14.9, respectively. There was no difference in disease-free survival (DFS), site of first recurrence, and overall survival (OS). When patients were in stage III, there was also no difference in DFS and OS. Conclusions: The ligation level of the IMA in rectal cancer may not influence oncological outcomes. However, further large-scale RCTs are needed to conclude this issue.
Relationship between Lower Tendency to Deceive in Aging and Inhibitory Compromise
Authors: El Haj Mohamad , Antoine Pascal
Published: July 2017

Background: Deception can be associated with a heterogeneous network of concepts such as exaggeration, misleading, white lies, and faking. This paper assesses the tendency to deceive in aging. Objective: Our main aim was to assess whether older adults would demonstrate a low tendency to deceive. Methods: A total of 42 older adults (mean age 67.64 years, SD 7.87) and 45 younger adults (mean age 21.71 years, SD 2.66) were administered a deception scale including items such as “I sometimes tell lies if I have to” or “I never take things that don't belong to me.” Participants were also administered an inhibition task. Results: The results demonstrated a low tendency to deceive and low inhibition in older adults compared with younger ones. The low tendency to deceive in the older adults was significantly correlated with their diminished inhibitory ability. Discussion: The low tendency to deceive in aging seems to be related to a difficulty in inhibiting an honest response. Since inhibitory compromise has been considered mainly to trigger negative consequences for cognition, the present paper illustrates how this age-related compromise can be associated with positive social outcomes, i.e., a low tendency to deceive.
ДОСЛІДЖЕННЯ УМОВ ЗРОСТАННЯ ТА СПОСОБІВ РОЗМНОЖЕННЯ ACHILLEA MILLEFOLIUM L. ТА ACHILLEA DIATANS WALD. ET KIT. В УМОВАХ ПРИКАРПАТТЯ
Authors: Neiko O. V. , Grytsyk A. R. , Melnyk M. V.
Published: July 2017

Мета роботи. Вивчити особливості розвитку та способи розмноження Achillea millefolium L. та Achillea diatans Wald. et Kit. в умовах культури.Матеріали і методи. Лабораторну схожість насіння Achillea millefolium L. та Achillea diatans Wald. et Kit. визначали загальноприйнятими методиками. Масу 1000 насінин визначали за допомогою аналітичних ваг. Для визначення розмірів насіння використовували бінокулярний мікроскоп МБС-10. Дослідження вегетативного способу розмноження підземних органів Achillea diatans Wald. et Kit. проводили діленням куща. Вивчено розсадний спосіб вирощування Achillea millefolium L. та Achillea diatans Wald. et Kit. за методикою Б. А. Доспехова.Результати й обговорення. Досліджено лабораторну і польову схожість насіння Achillea millefolium L. та Achillea diatans Wald. et Kit. при обробці низькими температурами. Вивчено вегетативний та розсадний спосіб вирощування Achillea diatans Wald. et Kit. Проведено фенологічні спостереження за етапами органогенезу Achillea diatans Wald. et Kit. Встановлено, що при вирощуванні розсади рослини відрізняються швидким ростом у кінці першого року вегетації, цвітуть на другий рік життя.Висновки. За результатами досліджень вивчено насіневу продуктивність, способи розмноження, умови вирощування розсади Achillea millefolium L. та Achillea diatans Wald. et Kit.
РОЗРОБКА ТА ВАЛІДАЦІЯ СПЕКТРОФОТОМЕТРИЧНОЇ МЕТОДИКИ КІЛЬКІСНОГО ВИЗНАЧЕННЯ ЕНІСАМІУМУ ЙОДИДУ В КАПСУЛАХ
Authors: Burmaka О. V. , Gureyeva S. M. , Margitich V. M.
Published: July 2017

Мета роботи. Розробити методику кількісного визначення енісаміуму йодиду в капсулах із застосуванням методу абсорбційної спектрофотометрії в ультрафіолетовій області.Матеріали і методи. Використано стандартний зразок енісаміум йодиду та зразок готової лікарської форми виробництва ПАТ «Фармак». У ході роботи було встановлено оптимальну робочу концентрацію енісаміуму йодиду 0,02 мг/мл. Дослідження проводили із застосуванням спектрофотометра «Specord 250 Plus».Результати й обговорення. Продемонстровано, що оптимальна довжина хвилі при визначенні становить 267 нм. Вивчено валідаційні характеристики методики в діапазоні 0,016-0,024 мг/мл (80-120%): специфічність, правильність, прецизійність, лінійність, діапазон застосування, робасність, внутрішньолабораторна прецизійність відповідно до рекомендацій Міжнародної конференції з гармонізації. Коефіцієнт кореляції (r) між введеним та знайденим значенням для енісаміуму йодиду становить 0,99996, а відносний довірчий інтервал (Dz) 0,23 %. Підтверджено стабільність розчинів при їх зберіганні при кімнатній температурі протягом 48 годин.Висновки. Розроблено спектрофотометричну методику кількісного визначення енісаміуму йодиду в капсулах, експериментально доведено, що вона придатна для контролю якості капсул енісаміуму йодиду.
Materialize: Acervo Físico e Digital de Materiais da FAU-USP
Authors: Bertoldi Cristiane Aun , Dantas Denise
Published: July 2017

Materialize é o acervo de materiais criado para auxiliar disciplinas dos cursos Design e Arquitetura e Urbanismo da FAU-USP, que contou com a parceria do Materiali e Design, coordenado pela Profa Dra Bárbara Del Curto, do Istituto Politecnico di Milano, e foi beneficiado por financiamento da Pró-Reitoria de Graduação da USP. Esse acervo digital poderá ser consultado on-line por docentes, alunos e pesquisadores, em plataforma aberta, com acesso irrestrito. Apresenta informações sobre características, qualidades e propriedades das amostras de materiais presentes no acervo, sua utilização, processos de transformação e fornecedores brasileiros. O acervo físico poderá ser consultado no LabDesign na FAU-USP, mediante agendamento.
Mapas Conceituais para Avaliação do Ensino- Aprendizagem em uma Disciplina de Engenharia de Transportes
Authors: Silva Júnior Carlos Alberto Prado da , Fontenele Heliana Barbosa , Silva Antônio Nélson Rodrigues da
Published: July 2017

O objetivo principal deste estudo foi realizar uma análise comparativa dos resultados obtidos a partir do uso de duas técnicas diferentes para a avaliação do processo de ensino-aprendizagem em um curso de graduação em Planejamento e Análise de Sistemas de Transportes. A primeira é uma abordagem tradicional, que se baseia essencialmente em provas e testes, enquanto a segunda se vale de mapas conceituais. Os mapas conceituais construídos por cada aluno durante o curso foram cuidadosamente analisados e receberam notas objetivas. A nota final atribuída aos mapas foi então comparada com a média das notas atribuídas aos exames e questionários de cada aluno. Os resultados da comparação sugerem que os mapas conceituais podem auxiliar e aperfeiçoar a avaliação do processo de ensino-aprendizagem. Além disso, os mapas tornaram a avaliação mais abrangente em relação à evolução cognitiva, ao domínio conceitual e de relações conceituais para o caso específico deste estudo. O estudo conclui que os mapas conceituais constituem uma alternativa potencialmente útil para complementar outras estratégias de avaliação do ensino-aprendizagem.
E-Book Planejamento do Ensino: Apoio para a Formação de Estudantes do Curso de Bacharelado e Licenciatura em Enfermagem
Authors: Góes Fernanda Dos Santos Nogueira de , Andrade Luciane Sá de , Corrêa Adriana Katia , Souza Maria Conceição Bernardo de Mello e , Clapis Maria José , Gonçalves Marlene Fagundes Carvalho , Silva Marta Angélica Iossi , Camargo Rosangela Andrade Aukar de
Published: July 2017

Buscou-se aqui relatar o processo de construção de um livro digital sobre planejamento do ensino no contexto da Educação Básica e Profissional em Enfermagem para ser utilizado como recurso auxiliar por alunos de graduação em Enfermagem da Escola de Enfermagem de Ribeirão Preto-USP. Tal iniciativa deu-se a partir do trabalho de um grupo interdisciplinar de docentes que adotou o referencial teórico da problematização, e, para a construção da metodologia empregada, utilizou quatro fases sequenciais: definição do escopo, planejamento, produção e implementação. Para a avaliação do e-book foram convidados oito experts em conteúdo. Na primeira etapa, o grupo de docentes realizou vários encontros, e optou-se pela estruturação seguindo as etapas de um plano de aula. Assim, foi produzido um e-book de onze páginas no qual foram reunidos texto e mídias como links para vídeos armazenados na internet. Na avaliação de layout e conteúdo, os peritos emitiram opiniões as quais foram incorporadas na versão final do e-book. Concluiu-se que desenvolver o livro digital possibilitou a atuação interdisciplinar docente. Além disso, a obra em questão contribui para suprir a lacuna existente de materiais educativos e inovação no processo de ensino-aprendizagem da Licenciatura em Enfermagem, de modo a atender ao novo perfil de alunos que se apresenta.
A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective
Authors: Yu Baoqi , Kiechl Stefan , Qi Dan , Wang Xiaocong , Song Yanting , Weger Siegfried , Mayr Agnes , Le Bras Alexandra , Karamariti Eirini , Zhang Zhongyi , Barco Barrantes Ivan del , Niehrs Christof , Schett Georg , Hu Yanhua , Wang Wen , Willeit Johann , Qu Aijuan , Xu Qingbo
Published: July 2017

Background:

Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is known about its role in atherosclerosis.

Methods:

We tested the hypothesis that DKK3 is atheroprotective using both epidemiological and experimental approaches. Blood DKK3 levels were measured in the Bruneck Study in 2000 (n=684) and then in 2005 (n=574).
DKK3
-deficient mice were crossed with
apolipoprotein E
-/-
mice to evaluate atherosclerosis development and vessel injury-induced neointimal formation. Endothelial cell migration and the underlying mechanisms were studied using in vitro cell culture models.

Results:

In the prospective population-based Bruneck Study, the level of plasma DKK3 was inversely related to carotid artery intima-media thickness and 5-year progression of carotid atherosclerosis independently from standard risk factors for atherosclerosis. Experimentally, we analyzed the area of atherosclerotic lesions, femoral artery injury-induced reendothelialization, and neointima formation in both
DKK3

-/-

/apolipoprotein E

-/-

and
DKK3

+/+

/apolipoprotein E

-/-

mice. It was demonstrated that DKK3 deficiency accelerated atherosclerosis and delayed reendothelialization with consequently exacerbated neointima formation. To explore the underlying mechanisms, we performed transwell and scratch migration assays using cultured human endothelial cells, which exhibited a significant induction in cell migration in response to DKK3 stimulation. This DKK3-induced migration activated ROR2 and DVL1, activated Rac1 GTPases, and upregulated JNK and c-jun phosphorylation in endothelial cells. Knockdown of the ROR2 receptor using specific siRNA or transfection of a dominant-negative form of Rac1 in endothelial cells markedly inhibited cell migration and downstream JNK and c-jun phosphorylation.

Conclusions:

This study provides the evidence for a role of DKK3 in the protection against atherosclerosis involving endothelial migration and repair, with great therapeutic potential implications against atherosclerosis.
Studies on Erasmus
Authors: Elliott J.K.
Published: July 2017

During the many celebrations in 2016 to mark the 500th anniversary of the publication of Desiderius Erasmus’ first Greek-Latin New Testament (Instrumentum) several books have appeared on Erasmus or are editions of his works.
Four new species of Euphorbia sect. Pithyusa (subg. Esula, Euphorbiaceae) from SW Asia
Authors: PAHLEVANI AMIR H.
Published: July 2017

Four new SW Asian species of Euphorbia subg. Esula, sect. Pithyusa are described and mapped. Euphorbia acanthoclada is known from W Afghanistan and is compared with E. acanthodes. Euphorbia boreo-baluchestanica and E. ziaratensis are found from N Baluchistan of Pakistan and are most similar to E. prolifera and E. sulphurea respectively. Euphorbia kavirensis is known from temperate desert of the interior Iran, Dasht-e Kavir, and is closely related to the Iranian E. gedrosiaca. Diagnosis, description, distribution, ecology, conservation status, image and pertinent notes, if needed, are also considered.
One new species of the genus Xizicus (Orthoptera: Tettigoniidae: Meconematinae) from Chongqing, China
Authors: WANG HAI-JIAN , SHI FU-MING
Published: July 2017

The paper described one new species from Chongqing, China, i.e. Xizicus (Eoxizicus) simianshanensis sp. nov., it resembles Xizicus (Eoxizicus) divergentis (Liu & Zhang, 2000) and Xizicus (Eoxizicus) xiai (Liu & Zhang, 2000), but differs from the latter in: posterior processes of male tenth abdominal tergite straight; inner margin of base area of cerci with a notch, the other area of ventral surface after it enlarged inwards, with distinct edge; subgenital plate with posterior margin narrow, with styli stout and short.
A new species of burrowing wolf spiders (Araneae: Lycosidae: Lycosa) from Iran
Authors: NADOLNY ANTON A. , ZAMANI ALIREZA
Published: July 2017

With over 2400 species in 123 genera, Lycosidae is one of the largest spider families (WSC 2017). For over two hundred years, the type genus Lycosa Latreille, 1804 have accumulated large-sized wolf spiders from all over the world. Thus, with 218 nominal species, this genus is distributed in all zoogeographical regions (WSC 2017). Almost none of the species currently classified in Lycosa appear to be related to the type species—L. tarantula (Linnaeus, 1758); hence, the genus is polyphyletic and should be divided into several genera. This process has been already started; for example, in Australia and New Zealand where many of large wolf spiders have been removed from Lycosa (Roewer 1955, 1959, 1960; Vink 2002; Framenau & Baehr 2016). Also, some Holarctic, Neotropic and Afrotropic species were transferred from Lycosa to other genera (for a complete list of references see WSC 2017). In the Palaearctic, Lycosa is represented by 60 species (WSC 2017) and remains almost unrevised. From the southern Palaearctic, Saharo-Gobian desert region (Yemel’yanov 1974), 36 species of Lycosa have been recorded to date, 6 of which are poorly described (WSC 2017).
Absence of “Organization Man” Types a Boon to West Europe
Authors: RALSTON RICHARD W.
Published: July 2017

But educational reflection of social rigidity lessens labor force's efficiency
Do Accountants Really Account?
Authors: KLEINERMAN DAVID
Published: July 2017

Not always, concludes this C.P.A. who asks that laymen be critical
The Judicial-Legal Definition of Discrimination in Testing
Authors: Gold Margaret G. , Bruno Joseph F.
Published: July 2017

In the last several years, there has been a revolution in the field of personnel testing. The revolution is due to the fact that the federal courts have assumed the role of tester of testers in extending a series of challenges to civil service and other personnel examinations. The ramifications of this intervention by the federal courts into personnel testing have been far-reaching. Public and private employers can no longer casually select an examination or other personnel selection device without running the risk that a successful challenge will be made to the list resulting from the test, thereby preventing appointments from being made. The result has clearly been a more careful application of the principles of sound test construction by civil service commissions and personnel departments.
Testing for Licensing and Certification Outside Education
Authors: Shimberg Benjamin
Published: July 2017

What can educators learn from testing in and for noneducational occupations? In response to this question, I would like to share some of the lessons learned from, the studies of licensing and certification at the Center for Occupational and Professional Assessment, a unit of the Educational Testing Service. At the outset, however, it might be helpful to clarify the terms “licensing” and “certification” and how they relate to employment.
Public Policy Issues in the Quota Controversy
Authors: Greenberg Deborah M.
Published: July 2017

The quota controversy is a highly emotional one. Many whites fear that quotas mean the end of the merit system. Minorities previously denied access to mainstream institutions feel that they should be put in the position they would have reached, but for discrimination, as quickly as possible. Men fear that jobs previously reserved for them will be overrun by women, and so on. As I shall illustrate shortly, however, when the issues are viewed in terms of concrete situations, rather than in the abstract, the areas of disagreement narrow, and it usually becomes unnecessary to resolve the broad general issues concerning quotas, goals, or other preferential treatment.
Enhancing Accounting Education and the Accounting Profession in Developing Countries
Authors: Novin Adel M. , Baker James C.
Published: July 2017

Many problems stand in the way of the enhancement of accounting education and practice in developing countries. These problems require careful study in order to expedite economic development in these countries. This study, through a survey of field experts, identifies cultural, economic, educational and professional factors that are obstructing the development of accounting education and accounting practices in developing countries. In addition, it identifies and ranks some 21 remedial strategies for enhancing accounting education and practice. The results of this study would be of help in the development of relevant and effective accounting systems in developing countries.
Export Subsidies in India: Need for A Strategic Approach
Authors: Narayana M.R.
Published: July 2017

The persisting trade imbalances, mounting external debt and its servicing burden, depleting foreign exchange reserves, etc., have often led to considering export promotion as a policy alternative for India. However, our continuing reliance on industrial market economies for exports underlines the importance of competition (imperfect) in product quality and price. The analytical re!lults of this paper show that if the underlying imperfect market structure of India's export trading is characterized by Cournot duopoly, the impact of export subsidies can be favourable in terms of larger market share for home exporting firms. This short-term advantage is mainly attributed to rent, or profit sharing of home firms initially earned by foreign firms in home market. These results offer strong economic support for the strategic export policy, yet to be formulated in India, or justification for the current export policy if only the subsidized exporting domestic firms behaviour is strategic, and provide the economic basis for empirical estimation of export earnings by a strategic export subsidization policy as compared to the existing nonstrategic policy.
International List of Human Factors Films
Authors: Carter Charles W.
Published: July 2017

An annotated bibliography of films dealing with Human Factors problems is presented. The list is source categorized under: Government Agencies, Universities, National Societies, Industry—Aircraft, and Industry—General.
Studies of Air Loads on Man
Authors: Swearingen J. J. , McFadden E. B.
Published: July 2017

Data obtained in three different studies related to measurement of forces on the body due to air movement are summarized. The effects of short duration blast forces on personnel seated or standing at various distances from openings during pressure loss, blast forces necessary to disorient the body from numerous positions, effects of clothing on the drag forces, and measurements of forces and moments on the body during wind tunnel tests are discussed and compared.
The New Field Theory: An Application to Postal Automation
Authors: Asher James J. , Post Richard I.
Published: July 2017

To solve complex human problems such as those usually found in engineering psychology, theoretical models should function as heuristic stimulant for the invention of solution possibilities. These solutions were called stimulus fields which when invented then suggest many hypotheses testable with experiments. The exploration of the invented system with experimental research is necessary because most of the process or variance within the system is unknown, but discoverable. This schema of neo-field theory was illustrated with a complex problem of mail encoding by postal operators. The problem was concerned with informational decision-making by postal operators who in the future may encode mail for computer processing.
The Relevance of Vigilance Research to Aerospace Monitoring Tasks
Authors: Kibler Austin W.
Published: July 2017

The basic task dynamics of classical vigilance research are outlined and compared with those of representative contemporary monitoring tasks. It is argued that, while monitoring functions are increasing in modern technology, those particular functions on which the classical vigilance research paradigm is based are declining. The difficulty of generalizing from simple laboratory vigilance tasks to the generally more complex applied monitoring functions is discussed. It is suggested that the results of classical vigilance research may not be particularly germane to contemporary monitoring problems. Recommendations for future research are given.
Representation and Strategy in Diagnostic Problem Solving
Authors: Wortman Paul M.
Published: July 2017

Four experiments investigating diagnostic problem solving by clinical neurologists were performed. From protocols or verbal reports of physicians diagnosing neurological diseases we have identified several elementary structures used in clinical decision-making and compared them to some precisely defined information-processing primitives. A separate experiment established the reliability of the protocol information. The use of a tree structure as a representational model of the diagnostic process was tested, but not confirmed. In another experiment we discussed the implications of the elementary structures for the diagnostician's search strategy and noted two more strategy characteristics. Some hypotheses for an alternative representation and strategy were offered and it was suggested that a computer program could be used as a final test of this model.
Improving Time-Sharing Performance of Pilots Through Training
Authors: Gabriel Richard F. , Burrows Alan A.
Published: July 2017

Even with special display devices in gestation, a pilot must satisfy his complete visual information needs by “time-sharing” between the intra- and extra-cockpit data sources. A sample of sixty military attack pilots, selected with the variable of flying experience in view, was divided into control and trainee groups. Using simple, generalized but adaptive simulation devices, the trainee group was trained over an eight-week period in display reading and in hazard detection. A comparison of the trainee group with the control group in a highly specific and complex simulated flying task, showed that hazard detection (such as collision) was improved significantly without in any way compromising other flying tasks.
A Red-Green Paradox?
Authors: Lavender H. Jerry , Ek-Strom Raymond M.
Published: July 2017

Because of the probability of human error in Interpretation of color coding from a system versus component standpoint, a pilot study was conducted to determine the extent/presence of color confusion.
Employee Participation in Manufacturing Job Design
Authors: Chaney Frederick B.
Published: July 2017

The purpose of this study was to determine the effect of employee participation in job design activities on manufacturing performance and employee attitudes. Nine supervisors were given training in the use of participative job design techniques. As part of this training, each supervisor conducted eight or more group problem-solving sessions with his employees. These groups and a matched control group, which did not use participative methods, were evaluated in terms of output, employee attitudes, and the level of participation. The percentage of favorable job attitudes and the amount of performance improvement were both positively related to level of group participation. Output was increased by 45 and 90%, respectively, in the groups which achieved medium and high levels of employee participation.
Human Factors Engineering in Manufacturing
Authors: Janousek James A.
Published: July 2017

This paper briefly reviews the first participation of human factors engineering in the identification and solution of manufacturing problems at Lockheed Missiles and Space Company. Electronics manufacturing management recognized the need for human factors engineering when new programs, more stringent quality requirements, and hiring of unskilled personnel gave rise to process control problems. During a six-month study period, many problems in the manufacturing area were discovered and reported, and those judged most critical were selected for detailed analysis and resolution. Many of the resulting recommendations were adopted, including major changes in design of manufacturing work stations.
The Nature of Industrial Inspection
Authors: Harris Douglas H.
Published: July 2017

A framework is provided for understanding and improving the accuracy of industrial inspection operations. The basic elements in inspection tasks—interpretation, comparison, decision making, and action—are described, and a classification of industrial inspection tasks is provided. Several basic factors that may influence inspection accuracy, and research results indicating the extent of their impact, are discussed. These factors include task complexity, defect rate, repeated inspections, and vigilance.
Work Physiology
Authors: Davis Harry L. , Faulkner Terrence W. , Miller Charles I.
Published: July 2017

The Human Factors Group at Kodak Park has been actively studying industrial jobs for ten years. Some of the most useful techniques of analysis are provided by the discipline of work physiology. This approach can be used: 1. To decide if a specific job is within the physical capabilities of people. 2. To decide which of two proposed methods is easier. 3. To evaluate in laboratory simulations the demands that will be posed by new jobs while they are still in the design stage. 4. To determine if a specific individual is able to perform certain jobs. 5. To rank jobs according to physical difficulty for wage and salary purposes. These applications are illustrated by discussing studies of actual industrial jobs.
The Effect of Instructional Format on Functional Testing Performance
Authors: Haney Richard W.
Published: July 2017

The objective of the study was to investigate the impact on test technician performance of an action-sequenced, tabular test instruction manual format. Error and time scores on this tabular format were compared to those on traditional test instructions written in narrative prose. The study results showed an error rate ratio of three to one favoring tabular test instructions for the sample of technicians chosen. It is recommended that tabular test instructions be employed for manual or semiautomated test sets.
What if Subjects Can't be Randomly Assigned?
Authors: Vaught Russell S.
Published: July 2017

Random assignment to treatment is not always possible in evaluative research. The semi-experimental design discussed here has aspects of both full experimental and quasi-experimental designs. Monte Carlo studies are used to explore and exemplify the strengths and weaknesses of the design. The analysis suggested is found to give unbiased estimates of treatment effects and error mean squares but biased estimates of assignment effects. Some further aspects of the design and its use are discussed.
The Human Dimensions of Water-Resources Planning
Authors: Harris Douglas H.
Published: July 2017

A framework was developed for incorporating human factors (those which concern human well-being and quality of human life) along with technical and economic factors into the water-resources planning-decision process. Initially, 388 water-resources concepts from the human domain were collected, screened, and grouped to define 42 different factors. Then, from ratings of similarity-dissimilarity by 300 raters, a matrix was generated of mean distances between all 861 possible factor pairs; the matrix was analyzed by computer-based multidimensional scaling techniques to determine the underlying dimensional structure. Finally, using procedures that paralleled those for determining factor similarity-dissimilarity, a value reflecting social importance was developed for each of the 42 factors and for the 5 basic dimensions which emerged from the multidimensional analysis. These values were found to cover a wide range; however, values for the same factors and dimensions were found to be nearly identical among different subgroups of people, even those with potentially divergent viewpoints, such as behavioral scientists and water-works professionals.
Modified Discriminant Analysis as a Multivariate Post-Comparison Extension of MANOVA for Interpretation of Simultaneous Multimodality Measures
Authors: Finkelman Jay M. , Wolf Edward H. , Friend Michael A.
Published: July 2017

Multiple ANOVAs applied to simultaneous multimodality measures often result in: (1) excessive alpha error, (2) loss of experimental power, and (3) loss of information regarding interdependence of the dependent variables. The appropriate solution, MANOVA, is not designed to extract maximum information from data. Two multivariate post-comparison techniques are presented to respond to this void: (1) Univariate F Tests which evaluate the impact of significant independent variables on each dependent measure and (2) Modified Discriminant Analysis which isolates the impact of each level of the significant independent variable on the aggregate dependent measures, while transformation of normalized weights of the characteristic vector into standardized weights determines the relative sensitivity of the dependent variables to main effects. Recommended post-comparison techniques are described and applied to representative research. An efficient computer package is proposed to facilitate computation of MANOVA, univariate F tests, characteristic roots, corresponding linear discriminant functions, and standardized discriminant weights.
Stimulus Presentation Rate in Vigilance
Authors: Wiener Earl L.
Published: July 2017

Four groups of 12 subjects were run for two sessions to determine the influence of stimulus presentation rate in a monitoring task. Two stimulus rates were used, 12 and 60 per minute. Stimulus rate significantly affected detections on both days, but no transfer effect was found.
Knobology Underwater
Authors: Carter Robert C.
Published: July 2017

Fifteen knobs representing types which might be used underwater were subjected to an experimental comparison to determine what types most enhance speed or accuracy of knob adjustment. Six U.S. Navy divers adjusted the knobs underwater while wearing diving gloves in a variety of temperatures, pressures, and diving equipment. Adjustments were made with emphasis on speed or accuracy at each of three positions on the divers. Results indicate that large diameter knobs can be adjusted underwater more rapidly and accurately than smaller knobs, and that some types of tactile markers enhance accuracy of knob adjustment underwater.
Evaluating the Sensitivity of Various Measures of Operator Workload Using Random Digits as a Secondary Task
Authors: Savage Ricky E. , Wierwille Walter W. , Cordes Richard E.
Published: July 2017

Problems have been encountered in previous research in developing a secondary task measure of mental workload that is both sensitive and stable. Ordinarily a single measure of secondary task is analyzed as an indicator of difference in workload. The purpose of the experiment reported here was to determine whether alternate measures taken from a single secondary task might prove more sensitive. Twelve subjects participated in the experiment involving a primary task (meter pointer nulling) and a secondary task (reading random digits aloud). The independent variable (primary task difficulty level) was adjusted by changing the number of meters that had to be monitored (two, three, or four meters). Dependent measures were taken on the (1) number of random digits spoken (usual workload formula), (2) longest interval between spoken responses, (3) longest consecutive string of spoken digits, and (4) the number of “triplets” spoken. Results show that the dependent measures (1), (3), and (4) were significant with (1) being the most sensitive.
On Thomas Mann's political career
Authors: Pross Harry
Published: July 2017

The world is always eager to perceive the contradictions in a great man's life and work. Thomas Mann, Nietzsches Philosophie im Lichte unserer Erfahrung