bluuebunny/crossref_metadata_2025 huggingface dataset:
Isoform-Specific Role of Akt Kinase in Cancer and its Selective Targeting by Potential Anticancer Natural Agents
Authors: Roy Nand Kishor , Monisha Javadi , Singh Anuj Kumar , Padmavathi Ganesan , Kunnumakkara Ajaikumar B.
Published: March 2019

Background:

Akt kinase is a serine/threonine kinase that plays an important role in different
cellular processes such as cell proliferation, apoptosis, glucose metabolism, transcription, and
cell migration. It has three isoforms (Akt1, 2, and 3) that have distinct and sometimes contrasting
functions in different cancers. However, to date, most of the inhibitors are directed against Akt
kinase generally which would not serve the purpose due to the lack of isoform selectivity and offtarget
toxicity. Therefore, the present study is an elementary step towards the demarcation of the
natural inhibitors available from food sources and dietary supplements using in silico methods.

Objective:

To demarcate the natural agents and general Akt kinase inhibitors into Akt isoformspecific
inhibitors.

Methods:

The genetic alterations data for Akt isoforms were obtained from The Cancer Genome
Atlas datasets. The protein sequence alignment was achieved using PRALINE program. The modeling
of Akt3 protein and its evaluation was performed by ModWeb Server and PROCHECK program,
respectively. The docking was performed by using Schrödinger Glide software.

Results:

Differential pattern of genetic alterations of Akt isoforms was observed in different cancers.
The protein sequence alignment has shown both the conserved as well as the non- conserved
region of Akt isoforms. The structure of Akt3 was successfully modeled and evaluated. Finally,
with the help of molecular docking, the natural agents and general Akt inhibitors have been segregated
into Akt isoform-specific inhibitors based on the derived Glide Score (GScore).

Conclusion:

Isoform-specific inhibition of Akt would have huge clinical significance and research
should be commenced in preclinical and clinical settings.
Adellijke echo’s? De invloed van de adel op de ontwikkeling van buitenplaatsen langs de rivieren van het Amstelland en de Oude Rijn
Authors: Van Oosterom Gerrit
Published: March 2019

This article claims that the influence of the nobility on the temporal and spatial development of the country house landscapes in the areas of Amstelland and the Oude Rijn was stronger than has previously been argued and remained visible long after the nobles themselves had left. In Amstelland the economic, social and cultural focus of the Catholic nobility that still owned land here shifted at the end of the seventeenth century to the southern part of the Netherlands and abroad. It offered the merchant elite of Amsterdam the opportunity to buy their prime locations and turn them into modern dairy farms combined with the first country houses in Amstelland. Along the Oude Rijn river many locations carried various noble connotations, which seemed to attract the status-sensitive members of the urban elite of both Amsterdam and Utrecht. They used the location – formerly a noble seat – and name of the place so as to associate themselves with a (true or fabricated) noble past.
Het politieke avontuur van een rode jonker
Authors: Van der Poel Stefan
Published: March 2019

Review of Anne-Marie Mreijen, De rode jonker. De eeuw van Marinus van der Goes van Naters 1900-2005 (Amsterdam: Uitgeverij Boom, 2018, 374 p., ill., index)
An alternative approach to measuring demand changes in meat markets
Authors: Bekkerman Anton , Brester Gary W. , Tonsor Glynn T.
Published: March 2019

Commodity groups, academics, government agencies, and marketing analysts often have strong interests in understanding changes in demand for products. It is often the case, however, that only equilibrium price and quantity data are available for identifying changes in demand. But, such equilibria are the result of both changes in demand and changes in supply – the latter of which causes changes in quantity demanded. Although an existing index-based method is widely used to identify demand shifts, we consider its theoretical foundation and empirical performance against a proposed alternative. We find that when using widely available but highly aggregated annual-level price and quantity data, our alternative better characterizes demand shifts for goods such as beef, pork, poultry, and lamb. For many agribusinesses that require information about market dynamics in their industry, our method is likely to provide a more accurate, low-cost assessment of demand changes over time.
USO DO PLACEBO EM PESQUISAS CLÍNICAS À LUZ DA BIOÉTICA
Authors: Santos Souza Tuany , Moraes Costa Silvania , Lago Da Silva Sena Edite , Donha Yarid Sérgio , Narriman Silva De Oliveira Boery Rita
Published: March 2019

Esse estudo objetiva caracterizar as pesquisasexistentes na literatura sobre o uso de placebosem pesquisas clínicas. Pesquisa descritiva, sob aforma de revisão integrativa de literaturamediante coleta de dados nas bases on-line BVS,Scopus e Web of Science. Os artigos selecionadosforam analisados sob um quadro sinóptico, adiscussão fundamentou-se na Declaração deHelsinque (2008). O uso do placebo équestionado sob seus aspectos éticos e médicos,pois contraria alguns princípios bioéticos, comoos de justiça, beneficência e não-maleficência. Ésalutar que se promova a proteção dosparticipantes da pesquisa, antes de qualquerconflito de interesse ou valorização de finslucrativos.
The impact of the financial crisis on earnings management: Empirical evidence from Italian and Spanish listed companies
Authors: De Luca Francesco , Paolone Francesco
Published: March 2019

Our study adopts a reliable and widely acknowledged model to detect accounts manipulation in order to assess the impact of the financial crisis on Italian and Spanish listed companies’ propensity to manage their earnings.
The analysis is conducted on 565 publicly traded companies on the Italian and Spanish financial markets during the time period 2005-2013.
We find a lower propensity to manipulate earnings in both countries during the pre-crisis period (2005-2008) as suggested by a decrease in the number of high-risk manipulators until 2008 included. With the spread of the financial crisis, companies become more manipulators. We believe that the reason for this is to avoid giving bad news to markets, investors, and lenders after that the crisis may have impacted too negatively on firms’ performance indicators and financial equilibrium. Our empirical results provide various implications for further studies related to managements’ incentives concurrently with security offerings.
BERPIKIR KRITIS SISWA DALAM PENYELESAIAN MATEMATIKA DITINJAU DARI PERBEDAAN TIPE GAYA KOGNITIF REFLEKTIF DAN IMPULSIF
Authors: Rahayu Yuli Aulia , Winarso Widodo
Published: March 2019

The essence of mathematics learning is the ability to solve math problems. Differences in ability, one of which is the suspect cognitive style. Based on the cause of the necessary mathematical problems of the students, cognitive style consists of a type of reflection and impulsive. So that the focus of this research is to analyze students' critical thinking skills in solving mathematical problems based on different types of reflective and impulsive cognitive style. Causal-comparative studies are needed to analyze the problem. The population of this study is composed of students of class VII SMPN 1 Susukan Cirebon. While the sample search uses the intentional sampling technique with the number of research samples 31 students. The technique of data collection using the Cognitive Style TMF test (correspondence familiar figures Test) and description Test (essay) Mathematics of critical thinking. The hypothesis test used is the t-test (T-test for independent samples). The results of the research show that the distribution of cognitive styles of students at SMPN 1 Susukan Cirebon, dominated by reflective-type cognitive style students (74% of students), while a small part of the students type of impulsive cognitive style (26% of students ). Critical thinking ability of reflective type students of cognitive style is better than the type of impulsive cognitive style students
PENERAPAN METODE PEMBELAJARAN DISCOVERY MENINGKATKAN PRESTASI BELAJAR IPA
Authors: Warsiki Ni Made
Published: March 2019

This research was conducted in Class IX-8 of Singaraja 2 Public Middle School in the even semester of the 2017/2018 school year, with the aim of improving student learning achievement in science learning by applying discovery methods. Data was collected through a learning achievement tests. Furthermore, the data were analyzed using quantitative descriptive methods. Data was presented in the form of average learning achievement and learning completeness process. The results showed that the learning achievement at the beginning of the average student learning achievement was only 73.63 with learning completeness only 40.74%, then after the implementation of the study it turned out that the student's learning achievement in the first cycle became an average of 79.81. With learning completeness reaching 59.26%, and in the second cycle student learning achievement reached an average of 82.61 with 88.89% learning completeness. Thus the conclusion of this study is that the application of the discovery method can improve student learning achievement in class IX-8 Singaraja SMP Negeri 2 semester even academic year 2017/2018

Keywords: discovery learning method, learning achievement
IDENTIFIKASI MISKONSEPSI SISWA KELAS X PADA TOPIK REAKSI REDOKS
Authors: Apriadi Ni Ngh. Sangging , Redhana I Wayan
Published: March 2019

Penelitian ini bertujuan mengidentifikasi miskonsepsi siswa pada topik reaksi redoks serta mendeskripsikan sumber miskonsepsi siswa pada topik reaksi redoks. Jenis penelitian ini adalah penelitian deskriptif. Metode yang digunakan untuk mengidentifikasi miskonsepsi siswa adalah metode CRI (Certainty of Response Index) yang dimodifikasi. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah tes yang disertai kriteria CRI, observasi dan wawancara. Data yang diperoleh berupa persentase miskonsepsi siswa, transkrip wawancara dan observasi yang dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa siswa mengalami miskonsepsi dalam (1) menentukan bilangan oksidasi berdasarkan jumlah atom yang terdapat dalam molekul atau ion; (2) elektron yang terlepas saat terjadinya oksidasi adalah elektron yang berada di sekitar atau di dekat inti atom; (3) reaksi pada katoda adalah reaksi oksidasi; (4) reaksi pada anoda baterai adalah reaksi redoks; (5) pembentukan ion negatif pada saat reduksi terjadi karena elektron pada atom berkurang; (6) menentukan nama senyawa tidak sesuai dengan bilangan oksidasi; (7) reduktor adalah zat yang mengalami oksidasi; (8) oksidator adalah zat yang mengalami reduksi; (9) muatan ion sama dengan nol; (10) reaksi redoks sama dengan reaksi autoredoks (11) sumber miskonsepsi siswa adalah kemampuan siswa, penalaran, guru, dan LKS.
PENERAPAN MODEL PEMBELAJARAN TEAM GAME TOURNAMENT (TGT) UNTUK MENINGKATKAN HASIL BELAJAR
Authors: Sugiata I Wayan
Published: March 2019

Pembelajaran di dalam kelas merupakan bagian yang sangat penting dari proses pendidikan. Jika pelaksanaan pembelajaran di kelas bermutu akan menghasilkan output yang berkualitas. Guru memiliki peran yang sangat besar dalam mengorganisasikan kelas sebagai bagian dari proses pembelajaran dan siswa sebagai subyek yang sedang belajar. Kemampuan guru dalam mengemas suatu rancangan pembelajaran yang bermutu tentu diawali dari persiapan mengajar yang matang. Salah satu upaya yang dilakukan untuk meningkatkan hasil belajar peserta didik adalah dengan menerapkan suatu model pembelajaran yang diharapkan mampu mengurangi atau bahkan menghilangkan kesulitan peserta didik dalam memahami materi laju reaksi. Model pembelajaran yang akan diterapkan adalah Team Game Tournament (TGT). TGT adalah jenis pembelajaran kooperatif yang dirancang untuk mempengaruhi pola interaksi peserta didik dan sebagai alternatif terhadap struktur kelas tradisional. Penelitian ini tergolong penelitian tindakan kelas dua siklus. Jumlah subyek penelitian sebanyak 31 peserta didik kelas XI MIA 6 SMAN 1 Malang. Prosedur pengumpulan data pada penelitian ini adalah tes tertulis dengan soal essay. Berdasarkan analisis data diperoleh prosentase hasil belajar afektif pada siklus I 58,94% dan pada siklus II meningkat menjadi 90,06%. Hal ini menandakan penerapan model pembelajaran TGT pada materi laju reaksi dapat terlaksana dengan baik.
Faktor pembentuk brand loyalty : peran self concept connection, brand love, brand trust dan brand image (telaah pada merek h&m di kota dki jakarta)
Authors: Andriani Meta , Dwbunga Frisca
Published: March 2019

Brand loyalty or customer loyalty is an important concept for many companies that can bring many benefits to companies, such as repeat purchases and brand recommendations to others, who then can reduce marketing costs. Trust in the brand is important and is a major factor in the development of brand loyalty. Along with the development of industry, entertainment, information and technology, style of fashion becomes a medium to demonstrate the existence of a person in the community. By following certain fashion, people can show their true identity. The purpose of this study was to determine the role of the Self Concept Connection, Brand Love, Brand Trust and Brand Image on the increase Brand Loyalty.The focus of this study object is H&M brand in Jakarta region. The data used in this study were gathered by spreading the questionnaires to users who have purchased the H&M brand is more than one time. This study used convinience sampling as a sampling technique and obtained 158 respondend and this data processed into this study result. This study uses SEM analyze to test the data.
Pengaruh Pemberian Ekstrak Daun Teh Hijau Terhadap Konsentrasi dan Kecepatan Spermatozoa Tikus (Rattus norvegicus) Setelah Paparan Asap Rokok
Authors: Susmiarsih Tri Panjiasih , Kenconoviyati Kenconoviyati , Kuslestari Kuslestari
Published: March 2019

Merokok dapat menyebabkan berbagai macam gangguan kesehatan, asap rokok mengandung bahan kimia berbahaya dan radikal bebas yang berpotensi menimbulkan infertilitas. Teh (Camelia sinensis) merupakan tumbuhan yang banyak mengandung polifenol flavonoid katekin (sekitar 30%-40%),senyawa ini berpotensi sebagai antioksidan kuat untuk menetralisir efek toksik radikal bebas.Tujuanpenelitian ini adalah mengetahui pengaruh pemberian ekstrak daun teh hijau terhadap konsentrasi dan kecepatan spermatozoa tikus (Rattus norvegicus) setelah paparan asap rokok. Subjek penelitian menggunakan 24 ekor tikus putih. Perlakuan terbagi atas: kelompok kontrol (K1 dan K2), kelompok paparan asap rokok dan pemberian ekstrak teh hijau (P1 dan P5), kelompok paparan asap rokok (P2 dan P5) dan kelompok pemberian ekstrak teh hijau (P3 dan P6). Periode perlakuan selama 30 hari (K1,P1,P2,P3) dan 45 hari (K2,P4,P5,P6). Dosis paparan asap rokok sebanyak 1 batang per hari dan ekstrak daun teh hijau sebanyak 200 mg/kg bb. Semen diperoleh dari epididimis bagian kaudal tikus. Analisis data konsentrasi dan kecepatan spermatozoa menggunakan uji ANOVA dan uji perbandingan LSD.Hasil penelitian menunjukkan pemberian ekstrak daun teh hijau mampu mempertahankan kecepatan gerak spermatozoa tikus setelah paparan asap rokok, namun pemberian ekstrak daun teh hijau tidak dapat memperbaiki konsentrasi spermatozoa setelah paparan asap rokok. Ekstrak daun teh hijau diindikasikan dapat memperbaiki kualitas spermatozoa.
The Percentage of Epiphytes Cover on The Seagrass Beds in Sepanjang Beach, Indonesia
Authors: Listiawati Vina , Rohmah Siti Naily , Alfan Dheny Choirul
Published: March 2019

Seagrasses are foundation plant species as they not only create their own habitat but also for other marine organisms. In estuarine and marine environments, they form beds and their leafy structure are the excellent substrate for the epiphytes. In this study, we aimed to investigate the percentage cover of epiphytes on the seagrass beds in Sepanjang Beach, Indonesia. 5 transect lines with 20 m in length with the 50 x 50 cm quadrat at the interval of 5 m were placed at the perpendicular angle to the shoreline. These transects were positioned from the furthermost of the western part to the middle part of the beach, represented the gradation level of human activities. The result showed that the percentage cover of epiphytes was significantly higher on the middle part of the beach compared to the side of the beach. This present study suggest that human activities could lead to the increasing of epiphytes cover on the seagrass beds.
Fen Bilimlerine Yönelik Öğrenme Modelinin Ölçme Değişmezliğinin İncelenmesi: PISA 2015 Örneği
Authors: UYAR Şeyma , KAYA UYANIK Gülden
Published: March 2019

Bu çalışmada PISA 2015 öğrenci anketinde yer alan öğrenci özelliklerine göre fen bilimlerine yönelik kurulan öğrenme modelinin Türkiye ve Singapur örneklemlerinde dil ve kültür açısından değişmezliği, Türkiye örnekleminde ise cinsiyetler arasında değişmezliği incelenmiştir. Bu amaçla yapısal eşitlik modeli temelinde yer alan çoklu grup doğrulayıcı faktör analizi LISREL 8.80 programında uygulanmıştır. Analiz sonuçları modelin Türkiye örnekleminde cinsiyetler arasında şekilsel ve metrik değişmezliği sağladığını, ancak skaler (güçlü) değişmezliği sağlayamadığını göstermiştir. Türkiye ile Singapur arasında ise model yalnızca şekilsel değişmezlik koşulunu yerine getirmiştir.
Öteki Devletler ve Milletler: Sosyal Bilgiler Ders Kitabı Analizi
Authors: OSMANOĞLU Ahmet Emin
Published: March 2019

Araştırma Türkiye’nin çağdaş devlet ve milletler ile
tarihî devlet ve milletlere bakışını tespit etmeyi amaçlamaktadır. Çalışma
nitel araştırma modeline dayalı doküman incelemesi tekniğiyle
yapılandırılmıştır. Araştırmada tabakalı örneklem tekniğine uygun olarak Milli
Eğitim Bakanlığı yayınevi kitabı seçilmiştir. Veriler doküman inceleme
tekniğine uygun olarak MaxQda 12 programı aracılığı ile toplanmış, veriler içerik
analizine tabi tutulmuştur. Analiz birimi kelime ve analiz bağlamı cümledir.
Araştırmada Türkiye ders kitaplarında milletleri şovenliğe sevk eden
"Nasyonalizm"in değil herkesin kendi milletini sevmesi ve onu
yükseltmek için çalışması anlamına gelen "Patriotisme"in benimsendiği
sonucuna ulaşılmıştır.
Sosyal Bilgiler Ders Kitaplarında Güncel Konulara Yer Verilme Durumunun İncelenmesi
Authors: TAŞKIN Ayşe , MEMİŞOĞLU Hatice
Published: March 2019

Bu
araştırmanın amacı, Sosyal Bilgiler ders kitaplarında güncel konulara yer
verilme durumunu tespit etmektir. Bu amaçla toplam 9 adet (5. - 6.  ve 7. sınıf) Sosyal bilgiler ders kitabı
incelenmiştir. Araştırmada nitel araştırma yöntemlerinden doküman inceleme
kullanılmıştır. Doküman olarak ders kitaplarından yararlanılmıştır. Ders
kitaplarında güncel konulara yer verilme düzeyi tespit edildikten sonra, elde
edilen bu veriler ışığında değerlendirmeler yapılmıştır. Bulgular sonucunda,
güncel konuların ünitelerde eşit şekilde dağılımının olmadığı tespit
edilmiştir. Bu durum, öğrencilerin güncel olaylara karşı duyarlı olmalarını
sağlamak amacıyla sosyal bilgiler ders kitaplarında daha fazla güncel olaya yer
veren düzenlemelerin gerekliliği ortaya çıkarmaktadır.
Sosyal Bilgiler Öğretmen Adaylarının Harita Çizme Becerileri
Authors: EROL Hüseyin
Published: March 2019

Bu araştırmada sosyal bilgiler öğretmen adaylarının
harita çizme becerileri incelenmiştir. Araştırma Adıyaman Üniversitesi Eğitim
Fakültesi Sosyal Bilgiler Öğretmenliği Bölümünde 3. sınıfta öğrenim gören 38
öğretmen adayı ile gerçekleştirilmiştir. Araştırma verileri 2017 yılı mayıs
ayında toplanmıştır. Araştırmaya katılan sosyal bilgiler öğretmen adaylarının
harita çizme konusunda genel olarak başarılı çizimler yapamadıkları ve
çizdikleri haritaların çok büyük hatalar içerdiği görülmüştür. Bu araştırmada
cinsiyetin harita çizme üzerinde etkili olduğu erkek öğretmen adaylarının kadın
öğretmen adaylarından daha başarılı çizimler yaptıkları sonucuna ulaşılmıştır.
Bu araştırmada akademik ortalamanın yüksek veya düşük olmasının öğretmen
adaylarının harita çizme becerileri üzerinde belirleyici bir etkisinin olmadığı
ortaya çıkmıştır. Yaşadığı ülkenin dışına hiç çıkmayan öğretmen adaylarının
daha başarılı çizimler yaptıkları görülmüştür. Bu araştırmada fakültede
gördükleri dersler içerisinde önem sırası açısından coğrafya dersini ikinci
sıraya koyan öğretmen adaylarının diğer öğretmen adaylarından daha başarılı
çizimler yaptıkları tespit edilmiştir. Öğretmen adaylarının mezun oldukları
lise türlerinin harita çizme becerileri üzerinde belirleyici bir etkisinin
olmadığı ortaya çıkmıştır.
Requerimientos hídricos del cultivo de Tabaco en el departamento del Huila
Authors: Torrente Trujillo Armando , Gasca Cesar , Trujillo Oscar
Published: March 2019

Se seleccionó un Typic Ustifluvent en Campoalegre - Huila de clima calido seco, para estimar los requerimientos hídricos del cultivo de tabaco, variedad Gold 371. El experimento transcurrió para un ciclo de cultivo (110 días). La metodología consistió en la adecuación del terreno para el riego por surcos y el drenaje superficial, el estudio físico-químico del suelo, la instalación de una estación básica para el balance hídrico y la colocación de tensiómetros a 10 y 20 cm de profundidad del suelo para el control de humedad. Las lecturas diarias de los tensiómetros y la humedad gravimétrica del suelo junto a la información de clima, permitieron establecer los balances hídricos para estimar la evapotranspiración real y el coeficiente empírico de cultivo. La evapotranspiración real del tabaco para el ciclo vegetativo fue de 405.14 mm y los coeficientes Kc para cada fase: Crecimiento lento 0.66, crecimiento rápido 0.83, floración 0.92 y maduración 0.87.
Cambios volumétricos en suelos magnésicos del valle del rio Cauca-Colombia
Authors: Torrente Trujillo Armando , Garcia Ocampo Alvaro , Amezquita Collazos Edgar , Escobar Chalarca Carlos Alberto , Sampayo Noguera Tomas Jose
Published: March 2019

Se ha reconocido una extensa área de suelos arcillosos con alta saturación de magnesio denominada suelos Magnésicos; que revisten un especial interés por incorporación a la producción agrícola intensiva y que requieren de su conocimiento previo para el manejo y recuperación eficiente. Se evaluaron las características físicas relacionadas con el cambio de volumen de suelos con alta saturación de magnesio intercambiable en el valle del rio cauca, que incide sobre sus propiedades y que son básicas para el planeamiento de prácticas de manejo.Se seleccionaron trece (13) suelos y se midieron los cambios de volumen mediante el encogimiento de muestras con núcleos de volumen conocido bajo condiciones controladas  de secado en laboratorio y se determinaron los índices y variables de contracción: volumen especifico del suelo (V), volumen específico lleno de aire (P), contenido de humedad (), contracción normal (n) y contracción residual (r). La contracción de volumen con el secado  de los suelos magnésicos influye de manera importante  sobre la disponibilidad de agua a los cultivos, la eficiencia en el suministro de agua de riego  y lluvia efectiva haciendo más complejo el manejo del suelo, ya que el factor hídrico (lámina de agua, frecuencia, dosis y tiempo de aplicación) determina su consistencia y la características para su uso y su disposición.
Los sistemas de gestión integrados un desafío para la ingeniería del siglo XXI
Authors: Ospina Angarita Alejandro
Published: March 2019

El nuevo milenio  ha traido consigo un sinnúmero de cambios y desafíos de todos los órdenes en cada aspecto del quehacer humano y como es obvio sin ser la excepción en nuestro rol como ingenieros. Atrás quedaron ideas tradicionales que relacionaban a los profesionales  de la ingeniería con una figura exclusivamente operativa, adornada de elementos exclusivamente técnicos y con una participación limitada a la ejecución de los procesos productivos sin integración a actividades propias de las organizaciones.
ДОСВІД УНІВЕРСИТЕТІВ ЄС У КОМЕРЦІАЛІЗАЦІЇ РЕЗУЛЬТАТІВ НАУКОВИХ ДОСЛІДЖЕНЬ
Authors: Honta Sergii
Published: March 2019

Основою становлення інформаційної економіки є формування та реалізація науково-інноваційного потенціалу країни, своєрідними генераторами якого є заклади вищої освіти (ЗВО). Зростаючого значення набуває налагоджені тісної взаємодії між підприємницьким сектором, громадянським суспільством та державою у сфері комерціалізації результатів наукових досліджень університетів. У статті розглянуті моделі та принципи комерціалізації результатів науково-дослідної діяльності, що реалізуються на практиці в окремих університетах країн ЄС, зокрема в Каунаському технологічному університеті, Вільнюському університеті (Литва), Ягелонському університеті та Вроцлавському університеті науки та технологій (Польща). Акцент зроблено на дослідженні організаційного, управлінського та інфраструктурного аспектів просування науково-дослідної продукції на відповідні сектори ринку.
Education NGOs in Makhanda, South Africa: A Zero Sum of Philanthropy and Survival
Authors: Nomsenge Sinazo Onela
Published: March 2019

Thought and commentary surrounding the upsurge of non-governmental organisations (NGOs) and their involvement in the design and implementation of development in the Global South are accompanied by an unrelenting set of contradictions and self-replicating inconsistencies. These are often embedded in the sector’s nomenclature, ideological underpinnings, intent and impact. Opposing bands of scholarship have sustained these tensions by securing NGOs both within the ambit of developmental thought and practice and also within the criticisms waged against western domination and its splinter models of modernity. In an attempt to extend these prevailing annotations, this paper holds the idealisation of NGOs up to scrutinous reflection within the context of Makhanda’s inequitable educational landscape by proposing that, in order to balance organisational uncertainties with the socio-economic urgencies upon which they trade, NGOs sustain several and, at times, competing affiliations all of which are central to organisational preservation and legitimacy. The tactical means by which organisations preserve these allegiances often deputise socio-economic and educational overhaul in favour of survival. Therefore, this article lays out the ways in which organisational urgencies intersect with contextually specific needs of reform in what becomes a zero sum of philanthropy and survival; this to the extent that, in large part, NGO interventions often serve to moderate, rather than uproot, the set of socio-economic features for which non-state intervention continues to be hailed and hallowed.
Buckling of Two-Dimensional Covalent Organic Frameworks Under Thermal Stress
Authors: Evans Austin , Ryder Matthew R. , Flanders Nathan C. , Vitaku Edon , Chen Lin , Dichtel William
Published: March 2019

Two-dimensional Covalent organic frameworks (2D COFs) are periodic, permanently porous, and lightweight solids that are polymerized from topologically designed monomers. The predictable design and structural modularity of these materials make them promising candidates for applications including catalysis, environmental remediation, chemical separations, and organic electronics, many of which will require stability to mechanical and thermal stress. Based on their reinforced structures and high degradation temperatures as determined by thermal gravimetric analysis (TGA), many reports have claimed that COFs have excellent thermal stability. However, their stability to heat and pressure has not been probed using methods that report on structural changes rather than the loss of volatile compounds. Here we explore two structurally analogous 2D COFs with different polymerization chemistries using in operando X-ray diffraction, which demonstrates the loss of crystallinity at lower temperatures than the degradation temperatures measured by TGA. Density functional theory calculations suggest that an asymmetric buckling of the COF lattice is responsible for the observed loss of crystallinity. In addition to their thermal stability, x-ray diffraction of the 2D COFs under gas pressures up to 100 bar showed no loss in crystallinity or structural changes, indicating that these materials are robust to mechanical stress by applied pressure. We expect that these results will encourage further exploration of COF stability as a function of framework design and isolated form, which will guide the design of frameworks that withstand demanding application-relevant conditions.
Tissue Scaffolds with Nanoscale Hybrid Coating Shining New Lights on Multi-Modal Bone Targeted Therapeutics
Authors: Guo Zhijun , Jiang Nan , moore Jessical , McCoy Colin , Ziminska Monika , Rafferty Cormac , Hamilton Andrew , Li Yubao , Zhang Li , Zhu Songsong , Sarri Gianluca , Sun dan
Published: March 2019

The challenging post-surgery management of bone metastasis sees the needs for multi-functional bone scaffolds that offer multi-modal therapeutic functions. Through a nature-inspired layer-by-layer assembly process, we developed a unique multi-functional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/ graphene oxide hybrid coating. Alternative layers of drug laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. For the first time, proof-of-concept on combining pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy have demonstrated, in the context of malignant bone cancer treatment. Our scaffold system can be tailored to the patient’s specific needs through loading of bespoke therapeutic agents and offering on-demand photothermal therapy. The methodology can also be generalized to create functional surfaces for a wide range of biomedical devices as well as for applications beyond healthcare technology.
Projeto Gráfico em Livros da Editora Cosac Naify: Cultura Material, Artesanato e Estetização
Authors: Silva Leonardo Nóbrega da
Published: March 2019

Este texto discute e articula algumas das categorias presentes na prática editorial da Cosac Naify ao promover o projeto gráfico como elemento fundamental de seu projeto editorial. Qual o espaço da produção artesanal diante de dinâmicas crescentemente industriais? Por meio de entrevistas, análise de catálogos, artigos de jornal e revista, revela-se um rico panorama em que se observam diferentes projetos postos em disputa na dinâmica da editora.
O lugar do gosto na cadeia de valor do café: um olhar a partir das cafeterias de Brasília e São Paulo
Authors: Lages Mauricio Piatti
Published: March 2019

Este artigo procura acompanhar as transformações do café ao longo de sua cadeia de valor, abrangendo desde os elos mais primários até o setor de serviços, quando entra em jogo a valorização das pequenas diferenças em termos gustativos. A partir do enlace entre produção e consumo, o artigo busca contribuir para a compreensão da especificidade da produção do valor no capitalismo contemporâneo
Autenticidade e Modernidade: entre o individual e o coletivo
Authors: Oliveira Helder Canal de
Published: March 2019

Há muito tempo o debate sobre autenticidade permeia o pensamento social, inclusive no Brasil. A relevância deste tema no pensamento social está associada à difusão da modernidade, do individualismo moderno e, recentemente, da globalização. Os primeiros passos desse debate são vistos no Romantismo Alemão ainda na passagem do século XVIII para o XIX. Benjamim, em seus estudos sobre a obra de arte, retomou esse tema no século XX. Atualmente, Charles Taylor é um dos principais debatedores desse assunto. Para ele, na contemporaneidade, há uma cultura da autenticidade. Esta liga-se a ideia de autodeterminação, autorrealização e autossatisfação. Desse modo, o foco de seus estudos recai sobre uma ética da autenticidade e sobre a maneira como um indivíduo se sente autêntico. Porém, ao mesmo tempo que surge essa cultura da autenticidade individualista, surge também o seu contraponto: uma autenticidade cultural. Isto é, discute-se se uma cultura é autêntica ou não, enfatizando o aspecto coletivo, não o individual. Esse outro lado da autenticidade pode ser visto nas discussões sobre identidade cultural, nacional, grupal etc. É neste ponto que o Brasil tem grande contribuição no debate com autores como Euclides da Cunha, Sílvio Romero, Ariano Suassuna, dentre outros. Hoje, a autenticidade cultural é retomada por muitos grupos, principalmente, como uma reação à globalização e/ou massificação cultural. Com isso, este trabalho pretende apresentar esses dois caminhos que perpassam o tema autenticidade.
Da artificação do desfile das escolas de samba à sala de aula como barracão do fazer
Authors: Porfiro Andre Luiz
Published: March 2019

O artigo pretende apresentar a Arte do Carnaval nas suas formas e feitos realizados no desfile das escolas de samba. Daí, engendraremos uma prática experimental em aulas do componente curricular Arte. Partimos da hipótese de que há saberes nos barracões de alegorias e fantasias e nos barracões de ala, locais de invenção, desenvolvimento e construção dos sonhos carnavalescos. Na tessitura da circulação dos saberes está outro espaço da investigação: a sala de aula. Iremos relatar algumas experiências realizadas com a arte do carnaval na sala de aula com alunos e alunas do Ensino Médio. A diversidade de materiais utilizados, as invenções, as releituras e ressignificações que acontecem nos barracões das escolas de samba convergem, na pesquisa, com os fazeres contemporâneos do ensino da arte na educação básica.
Caminhos do Carnaval
Authors: Mathias Roberta Filgueiras
Published: March 2019

O ensaio fotográfico foi produzido durante os dias 11 e 12 de fevereiro nas ruas ao redor do Sambódromo. A ideia é captar a fluidez e a construção dinâmica do Carnaval da Marques de Sapucaí- que altera o fluxo e o trânsito dos arredores. Pensar o comércio e a paisagem urbana construídas nessa época do ano e, que somente fazem sentido dentro dessa lógica, nos leva a múltiplas interpretações e fruições desses novos espaços criados.  Tanto as cores, quanto os corpos em movimento evocam uma estética própria de temporalidade reconfigurada.
Loucura, Subjetivação e Gênero
Authors: Santos Ronivaldo De Oliveira Rego
Published: March 2019

Trata-se de fazer o que chamamos de aplicação do método arqueogenalógico sobre os procedimentos e representações da loucura em Goiânia, particularmente nos processos que envolvem o Hospital Psiquiátrico Prof. Adauto Botelho. Para chegarmos a esse ponto, traçamos uma problematização histórica do desenvolvimento da psiquiatria no Brasil e suas relações com as principais concepções da reforma psiquiátrica pelo mundo. Somente aí chegamos ao contexto de Goiânia. Problematiza-se ainda como a construção de Goiânia se situa na ordem do progresso e trabalho da Era Vargas e como ela pode representar, à época de sua construção, o ideal de modernização e civilização do homem brasileiro. Finalmente, discute-se o tema da loucura como modo de subjetivação e sujeição dos indivíduos e as questõs de gênero, a partir do caso do referido Hospital, mais especificamente a partir do documentário Passageiros da Segunda Classe, que retrata o dia a dia dessa instituição.
Hipótesis sobre el tema "escritura femenina e hispanidad"
Authors: Reisz Susana
Published: March 2019

Es éste un conjunto de propuestas de carácter teórico e histórico-literario sobre la controvertida categoría "escritura femenina" y su manifestación en la producción literaria de Hispanoamérica y España en los ochenta y noventa. El objeto de estudio no es cualquier clase de literatura hecha por mujeres, sino tan sólo aquélla capaz de expresar formas de experiencia y de marginalidad específicamente ligadas al rol genérico "femenino". La selección del corpus está determinada por la convicción de que las modalidades de representación y las estrategias discursivas de la "femineidad" -junto con los tipos de marginación que ellas denuncian- pueden modificarse con el tiempo tanto como los estilos literarios en general y que, en este preciso momento histórico, se están produciendo cambios acelerados y relativamente homogéneos en todo el mundo hispánico.
La literatura como patrimonio: del "nation building" al "nation branding"
Authors: Santos Unamuno Enrique
Published: March 2019

A partir del concepto de patrimonio como herencia con capacidad de generar valor económico y una vez constatada la dificultad a la hora de llegar a una definición precisa de qué se entiende por patrimonio literario, el presente trabajo se centrará en dos paradigmas sucesivos en la creación y conservación de la cohesión sociocultural y la identidad nacional a través de la literatura entendida como bien patrimonial. Si los procesos blandos de nation building propios de la modernidad han sido afrontados con acierto por la Teoría de Polisistemas, el enfoque ligado a las políticas públicas conocidas como nation branding (la identidad nacional vendida como un producto a partir de una imagen de marca-país fomentada por el Estado) ha emergido en la posmodernidad globalizada como una nueva estrategia nacionalizadora que concede gran importancia al patrimonio cultural y literario en cuanto activos simbólicos y económicos. Ese «nacionalismo venal» subyace a muchos de los actuales procesos de patrimonialización literaria relacionados a su vez con el llamado mercado de las identidades. Las dificultades experimentadas por la teoría polisistémica para distinguir los factores socioculturales de la institución y el mercado han hallado así su resolución última en forma de una total fusión de ambos factores, un fenómeno que exige nuevas formas de pensar el sistema cultural en su conjunto y las prácticas literarias en particular.
Recursos narrativos de indagación en la identidad femenina y temáticas recurrentes en la novelística de María Luisa Bombal, Flora Yáñez y María Carolina Geel
Authors: Suárez Hernán Carolina
Published: March 2019

La novela escrita por mujeres en Chile experimenta un desarrollo importante entre 1930 y 1960 y comparte rasgos que han generado su agrupación bajo la etiqueta de escuela subjetivista. Este trabajo quiere contribuir a la caracterización de la novelística femenina con una revisión de las novelas publicadas por María Luisa Bombal, Flora Yáñez y María Carolina Geel. El objetivo es establecer vínculos entre las novelas de estas autoras analizando los recursos narrativos empleados para construir los personajes y señalar la recurrencia símbolos y temas. Se presta especial atención al discurso lírico y al modo de presentar la subjetividad.
María Eugenia MATÍA AMOR, "Las dimensiones de la memoria. La poesía de Arcadio Pardo". Valladolid, Universidad de Valladolid, 2018, 260 pp.
Authors: Ayuso César Augusto
Published: March 2019

Este artículo es una reseña del libro:

 Las dimensiones de la memoria. La poesía de Arcadio Pardo.

Autora: María Eugenia MATÍA AMOR

Valladolid, Universidad de Valladolid, 2018, 260 pp.
Edmond Cros: «Trato de desvelar los efectos de la ideología de una época no sólo en aquello que se dice a nivel de la comunicación consciente sino, y sobre todo, a nivel de lo no-consciente»
Authors: Linares Alés Francisco
Published: March 2019

Entrevista a Edmond Cros
Cost-effectiveness of measles control during elimination in Ontario, Canada, 2015
Authors: Ramsay Lauren C , Crowcroft Natasha S , Thomas Shari , Aruffo Elena , Teslya Alexandra , Heffernan Jane M , Gournis Effie , Hiebert Joanne , Jaeger Valerie , Jiaravuthisan Manisa , Sharron Jennifer , Severini Alberto , Deeks Shelley L , Gubbay Jonathan , Mazzulli Tony , Sander Beate
Published: March 2019

Background

Given that measles is eliminated in Canada and measles immunisation coverage in Ontario is high, it has been questioned whether Ontario’s measles outbreak response is worthwhile.

Aim

Our objective was to determine cost-effectiveness of measles containment protocols in Ontario from the healthcare payer perspective.

Methods

We developed a decision-analysis model comparing Ontario’s measles containment strategy (based on actual 2015 outbreak data) with a hypothetical ‘modified response’. The modified scenario assumed 10% response costs with reduced case and contact tracing and no outbreak-associated vaccinations; it was based on local and provincial administrative and laboratory data and parameters from peer-reviewed literature. Short- and long-term health outcomes, quality-adjusted life years (QALYs) and costs discounted at 1.5%, were estimated. We conducted one- and two-way sensitivity analyses.

Results

The 2015 outbreak in Ontario comprised 16 measles cases and an estimated 3,369 contacts. Predictive modelling suggested that the outbreak response prevented 16 outbreak-associated cases at a cost of CAD 1,213,491 (EUR 861,579). The incremental cost-effectiveness ratio was CAD 739,063 (EUR 524,735) per QALY gained for the outbreak response vs modified response. To meet the commonly accepted cost-effectiveness threshold of CAD 50,000 (EUR 35,500) per QALY gained, the outbreak response would have to prevent 94 measles cases. In sensitivity analyses, the findings were robust.

Conclusions

Ontario’s measles outbreak response exceeds generally accepted cost-effectiveness thresholds and may not be the most efficient use of public health resources from a healthcare payer perspective. These findings should be balanced against benefits of increased vaccine coverage and maintaining elimination status.
The Discovery of NEW Golobe and Its Amazing Healing System
Authors: Nature Science
Published: March 2019

Here, one reported a discovery of new golobe or a novel kind of zingiberaceae fruit in a forest of Layeni village located in Teon-Nila-Serua (TNS) district of Seram island, Maluku province, Indonesia in the late afternoon on 25th February 2019. The new golobe is very different from the four (4) formal types of golobe fruits studied before. After intense prompt investigations, the new golobe was named as Elim alliacea based on the taller tree and fruit hard skin structures as well as its unique taste. Furthermore, the healing system of the golobe was identified to be very excellence in handling toxic instantly. This discovery suggests a prominent potential of this fruit as multitasking healing herbal medicine for future complicated deceases on earth.
Psychological rehabilitation of medical workers with emotional burnout syndrome
Authors: Achkasov E. E. , Melnikov A. I. , Belozerov B. G. , Yaroslavskaya M. A. , Osadchuk M. A. , Asanov A. Yu. , Kuznetsov N. A.
Published: March 2019

Introduction. Health preservation for public health care workers, by means of psycho-rehabilitation programs managing stress in medical establishments, is a topical medical, psychologic and economic task.Objective. To study levels of emotional exhaustion, depersonalization and personal achievements reduction as psychologic burnout factors in workers of primary health care, depending on position and educational level, with specification of psychologic rehabilitation program and evaluation of its efficiency.Materials and methods. The study covered 137 female medical workers of outpatient departments in Moscow, with emotional burnout syndrome and length of service at least 5 years. Emotional burnout syndrome was assessed via a questionnaire «Occupational burnout» including 3 scales: «Emotional exhaustion» (1), «Depersonalization» (2) and «Personal achievements reduction» (3). 3 groups of the examinees were identified: group 1 — senior officers (15), group 2 — doctors (40), group 3 — nurses and paramedical personnel (82). All the examinees underwent 8 weeks of psychologic rehabilitation based on training of stress-resistance, personality development and relaxation methods.Results. Groups 1 and 2 demonstrated medium (scales 1 and 3) and high (scale 2) levels of emotional burnout syndrome, and the group 3 presented medium (scale 3) and low (scales 1 and 2) levels. All the groups responded positively on psychologic rehabilitation that decreased emotional exhaustion, increased responsibility for daily duties, improved and stabilized self-esteem.Conclusions. Manifestations of emotional burnout syndrome depend on peculiarities of medical workers’ occupational activities, position and educational level. Emotional exhaustion and depersonalization are more marked in senior officers and in doctors, than in nurses and paramedical personnel. Self-evaluation of occupational competence and activities is the same among all categoriesof the medical workers. psychologic rehabilitation enables to decrease symptoms of emotional burnout syndrome and is an important component of programs preserving working potential of medical establishments.
Conference Hashtags: A Case of #RTP18 – The 2018 Exercise and Sports Science Australia Conference
Authors: Stanton Robert , Hobson-Powell Anita , Rosenbaum Simon
Published: March 2019

Background: Twitter is increasingly used as a medium to communicate scholarly content and facilitate expedited knowledge translation. Academic conferences typically use event-specific hashtags to promote conferences and move conference-related conversations to the public domain. Like other health disciplines, exercise physiology and exercise science attract global interest, and Twitter used during conferences can promote conference content to a broader audience than attendees. However, despite conferences in these disciplines having previously used hashtags, no published studies have examined their use. This study examined the use of the #RTP18 during the 2018 Exercise & Sports Science Australia Research to Practice Conference.

Methods: Freely accessible Twitter data were mined using twdocs. Descriptive statistics were used to report the number of original tweets and retweets. Content analysis was used to differentiate original tweets related to specific conference sessions from tweets related to the conference in general. Data are presented for each day of the conference and overall for the three days of the conference.

Results: A total of 262 original tweets were identified using the hashtag #RTP18. Seventy-one percent (n = 187) of the original tweets were related to specific conference content, while n = 75 (29%) of original tweets were related to the conference in general. More than 11,500 retweets were identified across the duration of the conference. The mean retweet rate was 12.7 times and ranged from 0–73.

Conclusion: Twitter appears to be a powerful tool to extend the reach of conference activities. The use of social media may enhance organizational and personal networking opportunities for conference delegates.
Оптимізація методів очистки та інактивації збудника каліцивірозу котів
Authors: Недосєков В. В. , Козленко Т. Г.
Published: March 2019

Встановлено, що оптимальним методом одержання очищеного препарату каліцивірусу є осадження сульфатом амонію з подальшою очисткою антигенного матеріалу з використанням градієнтів концентрації сахарози, що дає можливість одержати очищений препарат збудника каліцивірозу котів, придатний для виготовлення антигену. Порівняльне вивчення режимів інактивації формаліну показало, що оптимальним для інактивації вірусу є вплив формаліну в кількості 0,2 % при температурі 37 °С і експозиції 72 години.

We found that the best method of obtaining a purified preparation of calicivirus is ammonium sulfate precipitation followed by purification of the antigenic material using gradient sucrose concentration, which enables to obtain purified preparation pathogen, suitable for the production of antigen. Comparative study modes formalin inactivation showed that optimal for virus inactivation is the effect of formalin in an amount of 0,2 % at 37 °C and 72 hours of exposure.