bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFICIENT PHOTOCATALYTIC ACTIVITY AND DEFLUORIDATION STUDIES OF METAL OXIDE/CLAY NANOCOMPOSITES
Authors: P. Mariselvi  , Kumar T. Anantha
Published: June 2022

In this work, we report the efficient photocatalytic activity and removal of fluoride from wastewater using metal oxide/clay nanocomposites. The nanocomposites were characterized by using XRD, SEM with EDAX, AFM, TEM, and UV-Vis absorption spectroscopy. The structural properties of nanocomposites have been characterized by XRay Diffraction (XRD) analysis. The surface morphology of the nanocomposites was analyzed by SEM and AFM analysis. Absorption spectra have been obtained using UV-Vis spectroscopy to find the optical band gap. In addition, photocatalytic degradation of methylene blue in an aqueous solution was performed using metal oxide/clay nanocomposites under the illumination of UV light
DESIGNING AND VIRTUAL SCREENING OF QUINAZOLINONE ANALOGUES AS POTENTIAL PHARMACOPHORES FOR ANTITUBERCULAR ACTIVITY
Authors: Dhar Susmita , Datta Samaresh , Pradhan Soumya Ranjan
Published: June 2022

Drug-resistant infections, particularly Mycobacterium tuberculosis, have increased dramatically in recent years, necessitating the discovery and development of novel antimycobacterial drugs. Quinazolinone derivatives are widely utilized in the pharmaceutical industry and medicine for a variety of biological activities including antiinflammatory, antibacterial, antioxidant, anticancer, and antihypertensive effects. The goal of this study is to use the VLife MDS software package, version 3.0, to conduct G-QSAR and docking investigations on a series of 2, 3- substituted quinazoline-4(3H)-one for antitubercular activity. The compounds were chosen based on their expected activity from the G-QSAR model, and molecular docking research was used to verify and identify their affinity for the DNA gyrase protein. 52 molecules in a series of 2, 3- substituted quinazoline-4(3H)-one were subjected to GQSAR, which allows flexibility to study molecular substitution sites. With different QSAR model studies (2D, 3D, and G), we designed and predicted new chemical entities i.e. NCE’s which were screened by Lipinski’s rule of five. The lowest MIC compounds in the series and NCEs were docked onto a DNA gyrase protein, and the docking score was compared to that of the standard medication sparfloxacin
THE MOLECULAR APPROACH OF NATURAL PRODUCTS AS PANCREATIC CANCER TREATMENT: A REVIEW
Authors: Lubis M. F. , Hasibuan P. A. Z. , U. Harahap  , D. Satria  , H. Syahputra  , M. Muhammad  , R. Astyka
Published: June 2022

Pancreatic cancer is one of the most feared types of cancer because of the high number of deaths from this disease. High cases of death are reported due to the ineffectiveness of the early detection process of this type of cancer and the low effectiveness of treatment. This review reports a natural product that has the potential to be used as an anticancer of the pancreas. Natural products are the focus of researchers due to the low risk of resistance and side effects of these products. The mechanism of action of natural products is also explored to ensure the activity of natural products as anticancer, including molecular mechanisms of action, cell cycle inhibitory activity, and promoting apoptosis. Natural products are ingredients that are widespread around us, very easy to find, and have a lot of evidence of their effectiveness as anticancer. It is hoped that this review will become the basis for researchers to conduct further exploration of natural products as pancreatic anticancer.
Review on: Ulitchev I. I. (2021) Doctine of Person in V. N. Lossky’s Theological Personalism: Origins and Specifics. Moscow, PSTGU. 128 p
Authors: Парпара Анатолий Анатольевич
Published: June 2022

Рецензия на монографию Ивана Ивановича Улитчева, заведующего кафедрой систематического богословия Донской духовной семинарии, доцента кафедры новых технологий в гуманитарном образовании ИДО ПСТГУ, посвященую довольно сложному и дискуссионному вопросу о генезисе и значимости персонологии Владимира Лосского.

The review of the monograph by Ivan Ivanovich Ulitchev, Head of the Department of Systematic Theology of the Don Theological Seminary, Associate Professor of the Department of New Technologies in Humanitarian Education of IDO PSTSU, is devoted to a rather complex and debatable question about the genesis and significance of Vladimir Lossky's personology.
The Effect of Empowering Leadership on Ambidextrous Innovation in the Telecom Sector of Afghanistan
Authors: Faryad Fraidon , Gul Habib
Published: June 2022

The purpose of the current study was to examine the effect of empowering leadership (EL) ‎on ambidextrous (exploratory and exploitative) innovation and the mediating role of ‎creative self-efficacy (CSE) in the telecom sector of Afghanistan on the basis of social ‎exchange theory (SET). To achieve the goal a quantitative methodology was employed ‎and analyses were performed using Smart-PLS (version 3.2.8) software. The results ‎disclosed that Empowering leadership positively and significantly affects both ‎exploratory and exploitative innovations. Furthermore, mediation analysis revealed that ‎creative self-efficacy partially mediates the relationship between empowering leadership and ‎exploratory and exploitative innovation. The findings on creative self-efficacy as a ‎mediator can be considered a valuable contribution to the literature yet the current study had ‎some limitations too, like using a convenience sampling method and collection of the data ‎at one single point of time only. ‎
Causes of Time Delay and Cost Overrun of Rural Road Projects in ‎Afghanistan
Authors: Anwari Zabiullah
Published: June 2022

‎‎ The increasing frequency of cost overrun and time delay in rural road projects has been a concern for the government of Afghanistan. Based on a review of the MIS data from the MoPW and MRRD, almost all rural road projects which were implemented from 2015 to 2020 was not finished within fixed cost and time. In this study, the researcher found out the causes of time delay and cost overrun of rural road projects in Afghanistan. The study dwells on the qualitative approach and an open-ended interview were conducted with 10 people which are project managers, projects engineers, and employees of MRRD and MoPW and their contractors. According to the interviewees, there are 25 factors behind time delay and cost overrun of rural road projects in the country (16 for time delay and 9 for cost overrun). As a result of the volume of work that has to be done and resources to be utilized, there is the need to adopt best practices and strategies to ensure efficiency and quality delivery of service. The study recommends that the Ministry of Public Works (MoPW) and Ministry of Rural Rehabilitation and Development (MRRD) as main implementers of rural road projects in the country must strive to improve on their administrative role of monitoring the various contract management methods. By considering best strategies, practices are always adhered to, so that there will be successful road projects delivering in terms of fixed cost finishing with no further time extension.
Exploring Business Process Re-Engineering (BPR) ‎Efforts in Afghanistan s Public Sector -A Case ‎Study of the National Examination Authority (NExA)
Authors: Mansoor Jawad , Shahid Shams Muhammad , Mansoor Ghulam Farooq
Published: June 2022

‎‎ Recently the public sector of Afghanistan made a series of reforms to improve its service delivery ‎and eliminate widespread corruption. The National Examination Authority (NExA) being one of ‎them has made dramatic reforms aiming for a corruption-free and transparent process. The main ‎purpose of this study is to explore the efforts of Business Process Re-engineering (BPR) in the ‎public sector using NExA as a case study. The study adopted a qualitative methodology, with an ‎inductive approach, while the philosophy of the study is interpretivism and organization as the ‎unit of analysis. Based on the in-depth interviews, this study found that as a result of the ‎business process reforms, the examination process has improved vastly in terms of transparency, ‎cost, efficiency, and citizen happiness. This study also, found that Information Technology (IT) ‎played the main enabler role in the process. Other enablers were sound leadership, teamwork, ‎political and financial support, commitment to change, and merit-based recruitment. Resistance, ‎bureaucracy and insecurity were the constraints for BPR implementation. This study further ‎provides recommendations for the policymakers in terms of smooth implementation of the ‎business process re-engineering in the public sector organization. Limitations and future ‎implications are also discussed.‎‎
Penguatan Komunikasi Efektif Guru dalam Proses Pembelajaran di SMK Taruna Persada Dumai
Authors: Sugeng Purwantoro E.S.G.S  , Akbar Memen , Wardhani Kartina Diah Kusuma , Mardhiah Fadhli  , Yuli Fitrisia
Published: June 2022

One of the initial approaches to make learning more enjoyable is to know the patterns of social interaction and types of student communication. There are 3 types of social interaction patterns presented in this training, namely interactions between individuals who wish to achieve achievement (Achievement), desire to socialize with their social environment (Affiliation), and desire to power (Power). Teachers can communicate effectively with students if the teacher knows the type of communication used by students. There are 4 types of individual communication types with their environment. Some communicate concretely, spontaneously, intellectually, and sensitively. Community Service activities carried out are training for teachers to recognize the types of student social interactions and types of student communication. The training was carried out by introducing the two instruments that had been made. The training was held for 1 day offline at SMK Taruna Persada Dumai. Based on the feedback provided by the participants, the teacher felt the benefits of the training and was willing to apply the results of the training to students in the classroom.
Edukasi Menjaga Lingkungan Perairan Dengan Membudayakan Gaya Hidup 5 R (Recycle, Reduce, Repair, Replace Dan Reuse)
Authors: Situmorang Lisbet , Kasmawati Nunuk
Published: June 2022

Tujuan dari pengabdian ini adalah untuk memberikan pemahaman terkait pentingnya menjaga lingkungan guna kelestarian alam agar kedepannya masih bisa di nikmati bersama, memanfaatkan sampah untuk diolah kembali menjadi suatu produk dan bisa menjadi suatu usaha rumah tangga sehingga dapat membantu perekonomian keluarga. Metode atau pendekatan yang digunakan dilakukan secara tidak langsung, seperti kordinasi dengan pihak desa dilakukan secara daring yaitu chatting melalui whatsapp grup, vidiocall via whatsapp bersama anggota kelompok dan perangkat desa guna menyampaikan materi penyelesaian masalah serta program yang akan dijalankan, pengerjaan program kerja dilakukan dengan cara menitipkan kepada masyarakat secara langsung atau turun ke lapangan. Dengan terlaksananya program ini bertujuan untuk menambah wawasan ataupun pengetahuan serta kesadaran pada warga bahwa pentingnya eksistensi lingkungan tidak hanya menciptakan keindah dilingkungan sendiri saja, tetapi harus bersifat menyeluruh dimanapun manusia itu berada masyarakat khususnya desa Selerong kecamatan Sebulu dalam upaya edukasi tentang gaya hidup 5 R (recycle, reduce, repair, replace dan reuse).

 

The purpose of this devotion is to provide an understanding of the importance of maintaining the environment for the preservation of nature so that in the future it can still be enjoyed together, utilizing waste to be reprocessed into a product and can become a household business so that it can help the family economy. Method or approach used is done indirectly, such as coordination with the village is done online, namely chatting through WhatsApp group, videocall via WhatsApp with group members and village devices to convey problem solving materials and programs that will be run, work program work is done by leaving to the community directly or going down to the field. With the implementation of this program aims to increase insight or knowledge and awareness in residents that the importance of environmental existence not only creates beauty in their own environment but must be thorough wherever humans are in the community, especially Selerong village Sebulu subdistrict to educate about lifestyle 5 R (recycle, reduce, repair, replace and reuse).
Analisa Ekspansi Fast Food Richeese Factory Ke Negara Cina
Authors: Hasan Golan , Scorpianti Ervi , Jessy  , Wibowo Ricky
Published: June 2022

Bisnis dalam skala internasional membutuhkan inovasi dan pengembangan kemampuan yang kompeten. Perbedaan pasar yang dituju dan peluang yang kecil dapat menyebabkan kegagalan bagi bisnis yang ingin menembus pasar global. Meski demikian, salah satu perusahaan yang dianggap mempunyai potensi untuk menembus pasar global ialah PT Richeese Kuliner Indonesia yang bergerak dibidang restoran layanan cepat saji yang lebih dikenal sebagai Richeese Factory. Dengan lebih dari 73 cabang yang berada di hampir seluruh penjuru Indonesia Richeese Factory terbukti dapat menyajikan sajian yang dapat dinikmati dan berkesan di masyarakat Indonesia. Tujuan dari penelitian ini untuk melihat dan menganalisa potensi dari Richeese Factory untuk masuk ke Negara Cina. Penelitian ini dilakukan dengan menggunakan metode kualitatif deskriptif dengan metode pengumpulan data sekunder. Hasil dari penelitian ini menunjukkan bahwa Richeese Factory mungkin saja mengalami kendala jika ingin masuk ke pasar Cina, dikarenakan tipikal masyarakat Cina yang menghindari ketidakpastian dan perbedaan. Richeese Factory sebagai salah satu brand bisnis yang tidak berasal dari Cina akan kesulitan dalam menghadapi tipikal masyarakat Cina. Akan tetapi, hal ini tidak menjadikan masuknya Richeese Factory ke pasar Cina mustahil. Dengan mengadakan pertimbangan dan persetujuan antara kedua belah pihak, hal ini bisa terjadi. Konsep ini akan diberi judul “Analisa Ekspansi Fast Food Richeese Factory Ke Negara Cina”.
Pelatihan Penanganan Ikan Tuna Sirip Kuning (Thunnus albacares) Dengan Es Batu Secara Bulking Di PPI Hamadi Kota Jayapura
Authors: Siegers Willem Siegers , Kurniawan Ade , Dahlan Dahlan , Prayitno Yudi , Bariyyah Sitti Khairul , Tuhumury Ralph.A.N. , Nur Imran Syafei M.
Published: June 2022

The aims of this service is to increase the knowledge and skills of fish traders in handling yellowfin tuna by bulking using crushed ice cubes without mixing with water in the box and controlling the quality of fish using an organoleptic table score sheet during cooling process for three days. The method used is the early preparation of the training by conducting a pretest, delivering material and discussion, observing the quality assessment of fish by describing the changes that occur during storage with an explanation of the application theory as well as the implementation of practicum, interviews and evaluation of the final results of the activity by conducting a post-test. The results of the community service implementation attended by 15 participants from fish traders, about 48% was good in understanding and mastering the knowledge of refrigeration fish, about 28% was sufficient in accepting the knowledge and 24% was lacking in understanding the knowledge of refrigeration fish. The average value after given the training is 64.1.
Sosialisasi Identifikasi Bahan Tambahan Boraks Pada Kerupuk Di Kabupaten Karimun
Authors: Silitonga Friska Septiani , Eka Putra Ramdhani  , Okta Alpindo
Published: June 2022

One of the most produced food products was crackers. Crackers can be made from fish, shrimp, cuttlefish, and others, and cab be sold to improve the community’s economy. For improving the quality and durability of processed seafood products, food additives were added, on of which is preservatives. The problems was occured in the community were: 1) there were still food products that used borax as a preservative, 2) there was no education on how to identify borax in crackers, 3) provide education about the dangers of preservatives to health. The methods used in this activity were: 1) laboratory test for testing with flame test, and 2) the socialization step
Implementasi Program Pengembangan Kewirausahaan di Politeknik Negeri Bengkalis
Authors: Suharyono Suharyono , Dwi Astuti  , Marhadi Sastra  , Lidya Wati
Published: June 2022

The Entrepreneurship Development Program (PPK) is a community service program that aims to create new, independent entrepreneurs. PPK provides opportunities and opportunities for students and alumni of the Bengkalis State Polytechnic to utilize their expertise into business opportunities. The PPK has a positive impact in inspiring people to support the improvement of the campus entrepreneurial ecosystem. Students and alumni with skills that have economic value, are nurtured and prepared to become new entrepreneurs. Through the PPK, new entrepreneurs have been born in the fields of IT, animal husbandry, culinary, animation, creative economy, photogrammetry and geospatial information, MC services, printing, and drone services. The PPK is like a midwife for the birth of new and independent entrepreneurs in Bengkalis Regency.
Penggunaan Alat Bantu Papan Pelampung Dan Bantuan Teman Dalam Upaya Meningkatkan Keterampilan Gerak Dasar Renang Gaya Punggung Pada Peserta Didik Kelas XI IPA SMA Negeri 2 Siak Hulu
Authors: Yus Yetti
Published: June 2022

Berlatar belakang dari masalah  penelitian, yaitu rendahnya keterampilan gerak dasar renang gaya punggung peserta didik kelas XI IPA SMA Negeri 2 Siak Hulu. Kemudian  peneliti melakukan suatu tindakan dengan penelitian tindakan kelas untuk memberikan solusi dalam permasalahan yang terjadi di dalam kelas dengan penggunaan alat bantu papan pelampung dan bantuan teman dalam upaya peningkatan keterampilan gerak dasar renang gaya punggung. Jenis penelitian  yang digunakan adalah penelitian tindakan kelas, dengan subjek penelitian peserta didk kelas XI IPA SMA Negeri 2 Siak Hulu yang berjumlah 192 orang yang terdiri dari  enam kelas. Penelitian ini dilakukan dalam  dua siklus. Sedangkan teknik pengumpulan data  dilakukan melalui observasi dan dokumentasi dengan menggunakan  instrument penilaian keterampilan gerak dasar renang gaya punggung. Hasil penelitian pada siklus 1, diperoleh peningkatan keterampilan gerak dasar renang gaya punggung dengan  tingkat keterampilan sebesar 64.06% dengan kategori kurrang. Pada siklus 2, diperoleh peningkatan keterampilan gerak dasar renang gaya punggung  sebesar 91.67% dengan kategori tinggi. Ini menunjukkan bahwa penggunaan alat bantu papan pelampung dan bantuan teman dapat meningkatkan keterampilan gerak dasar renang gaya punggung pada peserta didik kelas XI IPA SMA Negeri 2 Siak Hulu, yaitu sebanyak 176 orang peserta didik atau 91.67%. Dengan demikian, dapat disimpulkan bahwa pengunaan alat bantu papan pelampung dan bantuan teman dalam upaya meningkatkan keterampilan gerak dasar renang gaya punggung pada peserta didik kelas XI IPA SMA Negeri 2 Siak Hulu dikatakan berhasil, karena diperoleh peningkatan keterampilan gerak dasar renang gaya punggung sudah melampaui indikator keberhasilan  dan dapat menjawab hipotesis penelitian.
Ethnic features of farming, or who has more livestock?
Authors: Lushnikova Olga
Published: June 2022

Researchers are studying the personal subsidiary farming to find ways out of the prolonged crisis of the rural areas. The one is as optimal “survival” strategy, especially for the indigenous ethnic groups of Russia, traditionally living in rural areas. However, this strategy isn’t suitable for all because of the difference in ethnic and cultural features and another condition (large/small countryside). This article attempts to assess the economic behavior through the prism of ethnic factor. It compares the features of livestock breeding among main ethnic groups of Khakassia (Russians and Khakass people). The role of the household varies for different groups: it’s a forced way of existence for some; it’s an additional source for others, while others don’t consider it as a source of income. Administrative and territorial features also affect the peculiarities of livestock breeding. The number of farmsteads and the composition of farm animals vary. The household as the main type of employment has the high potential for the indigenous population. There is such possibility for ethnic majority of the region in small countryside.
Merezhkovsky on Byron
Authors: Shishkova Irina
Published: June 2022

In the essays of Dmitry Merezhkovsky, the name of Lord Byron is often mentioned on a par with world classics. For the Russian writer, the English poet became an “eternal companion” who had a profound influence on his work. The article examines the image of Byron, depicted in bright strokes in the books “Eternal Companions”, “L. Tolstoy and Dostoevsky”, “It was and will be: Diary: 1910–1914”. Merezhkovsky was interested in Byron as a type of artist, a great master of words, a poet of the future. Merezhkovsky managed to analyze in detail the life and work of Byron, paying attention to such problems as Byron and Napoleon, the “superhuman”, the poet’s religiosity, the emergence of a new hero in literature, the so-called “egoism” of a genius, his freedom-loving revolutionary spirit. The paper provides Merezhkovsky’s thoughts of Byron’s internal and external “demonism” as well as the poet’s “torments” associated with the calling of a writer and a politician in the broadest sense of the word. In addition, the article considers the creative way of Pushkin, who, according to Merezhkovsky, overcame the gloomy mood of the English poet in his works. It also highlights the impact of Byron’s poetry on the authors who were “infected” with his liberal ideas. In conclusion, it is maintained that Byron did not die in vain, and according to Merezhkovsky, the epitaph on his grave could be the words “there will be joy”.
The Genre of Oaths in Mongolian-Manchurian Sources
Authors: Dampilova Ludmila
Published: June 2022

This paper analyzes the semantics and structure of oaths and relevant rituals of Mongols and Manchus in the period of the Qing Empire based on the materials from the source “Dayičing ulus-un mongγul-un maγad qauli”. Folklore and ethnographic materials are also used in the analysis. It is revealed that the structure and main elements of oath-taking ritual in the Manchu and Mongolian traditions are very similar, closely intertwined and trace their origins back to the kindred ancient mythological beliefs of the Central Asian peoples. Appealing to a supreme deity and a ritual sacrifice form the principal components of the oath-taking ceremony. Besides, a basic model of a mythological world serves as its foundation.
Idea and Spirit of Seven Years of Design and Crafts Based Workshops and Research on Site
Authors: Bartha B. , Olarescu A.M. , Gronegger T.
Published: June 2022

This paper is a holistic overview of 7 years of experimental design workshops and their vocational approach toward non-formal education in

the field of design. The research highlights more than 10 years of experience of the authors in organizing the workflow for a series of one-week international design workshops in Romania and Austria. Each workshop had a special topic but all of them were linked by a common scope: interventions in private and public spaces with inspiration and respect for the local built environment, culture, traditions, and crafts.
STATINS DRUG USE AND DRUG-DRUG INTERACTIONS
Authors: N.Setiawati Maria Caecilia , Mutiarawati Caecilia , Chasanah Uswatun , Fauziyyah Lina Fatin
Published: June 2022

ABSTRACT

Dyslipidemia is the commonest cause of many atherosclerotic diseases. Statins are the mainstay of

the management of dyslipidemia, and it is widely prescribed for patients in Indonesia. This study

aims to give an overview, the use of statin, and its drug-drug interactions. The study method was

descriptive, using a purposive sampling technic. The inclusion criteria were patients who received

statins therapy, in the outpatient installation of Tugurejo Regional Public Hospital, Semarang,

during April 2017. There were 334 patients meet the inclusion criteria, most of them were women

(63,28%). The highest patients’ range was 60-69 years old of 129 patients (38,62%). One hundred

and thirty-one patients (39,22%) were diagnosed with dyslipidemia only. The dosage range of

simvastatin and rosuvastatin was 10 to 20 mg once daily, but rosuvastatin was only given 10 mg

once daily. The most dose was 10 mg simvastatin per day, prescribed for 231 patients (69,16%).

There were 177 patients (52,99%) who has the potentiate of statin drug interactions. The most

were simvastatin-amlodipine interactions, occurs in 104 patients (31,14%). This study shows that

most statin users are elderly patients. Statin is used not only in dyslipidemia patients. There are

many potential statin drug-drug interactions, but the statin dose is low and not over the standard

doses.

Keyword: dyslipidemia, statins, drug interactions
UJI IRITASI DAN AKTIVITAS TABIR SURYA SECARA IN VITRO MINYAK BIJI PALA DALAM SISTEM MIKROEMULSI DENGAN VARIASI TWEEN 80-ETANOL
Authors: Rahmadany Sri Eka , Nida Aza Zakiyatun , Fithria Risha Fillah , Shabrina Ayu
Published: June 2022

ABSTRACTNutmeg oil contains of α-pinene that can be used as sunscreen but it is thermolable. It is necessary to form a microemulsion system for nutmeg oil. This study was to determine in vitro SPF value by and irritation index from nutmeg oil in microemulsion system with Tween 80-ethanol as surfactant and cosurfactant. The system were made with 6.4 % of nutmeg oil and Tween 80-ethanol as with concentrations of 45% (F1), 50% (F2), 55% (F3). The nutmeg oil microemulsion was determined SPF value using spectrophotometer UV. The irritation test was done by the patch test method on rabbit skin with 4 groups of negative control, F1, F2, and F3. The skin was observed at 24, 48 and 72 hours. Quantitative data were analyzed using one way Anova while irritation test data were described descriptively. The results of the sunscreen activity on nutmeg oil microemulsion for F1, F2 and F3 were 8,9 ± 0,12; 9,2 ± 0,51; and 9,3 ± 0,32 (p > 0,05). This SPF value were categorized in maximum protection. The primary irritation index values for F1, F2 and F3 were 0,1±1; 0,3±2,5; 0,1±0; so it can be concluded that microemulsion of nutmeg oil were very mildly irritating.Keywords: irritation, microemulsion, nutmeg seed oil, sunscreen activity
STABILITAS NANOSTRUCTURED LIPID CARRIER COENZYME Q10 DENGAN VARIASI WAKTU PENGADUKAN
Authors: Khasanah Usrifatul , Rochman M Fatchur
Published: June 2022

ABSTRACTCoenzyme Q10 (Co-Q10) or Ubiquinone is an antioxidant that is unstable to light and is highly lipophilic causing instability during storage, so a Nanostructured Lipid Carrier (NLC) delivery system is needed that can improve stability. The manufacture of NLC uses the emulsification method by melting two types of lipids, namely solid lipid cetyl palmitate and liquid lipid alpha tocopherol with the help of stirring using a magnetic stirrer. The purpose of this study was to determine the characteristics and stability of NLC Co-Q10 at various stirring times. The results of testing the characteristics NLC Co-Q10, that stirring for 6 and 9 minutes, obtained pH values of 6,64 and 6,62 with particle sizes of 215.03 nm and 188.25 nm, the entrapment efficiency values were 75.57% and 77.96%, respectively. Increasing the speed and duration of stirring in the manufacture of the NLC Co-Q10 system will obtain high trapping efficiency values and be more stable in storage at room temperature for 28 days.Keywords: coenzyme Q10, emulsification, nanostructured lipid carriers, stability.
Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 19 No. 1 Juni 2022
Authors: Redaksi Pengantar
Published: June 2022

Pemimpin Umum/ Penanggung jawab Dekan Fakultas Farmasi Universitas Wahid Hasyim Pemimpin Redaksi Ketua Program StudiFarmasi Fakultas Farmasi Universitas Wahid Hasyim Dewan Penyunting Jurnal Dr. Yulias Ninik W., M.Si., Apt. Redaktur Ahli Dr.apt. Ahmad Ainur Rofiq, M.Si (Universitas Sebelas Maret), Dr. apt. Burhan Ma’arif Zaenal Arifn, M.Farm (UIN Maulana Malik Ibrahim), Dr. apt. Isnaeni, M.S (Universitas Airlangga), apt. Kuni Zu’aimah Barikah, M.Farm (Universitas Jember), Prof. Dr. apt Nurkhasanah, M.Si. (Universitas Ahmad Dahlan), a p t . Khoerul Anwar, M.Sc (Universitas Lambung Mangkurat), Dr. apt. Gunawan Pamudji Widodo, M.Si (Universitas Setia Budi), Dr. apt. Laela Hayu Nurani, M.Si. (Universitas Ahmad Dahlan), Dr. apt. Iis Wahyuningsih, M.Si. (Universitas Ahmad Dahlan), Dr. apt. Wahyu Widyaningsih, M.Si (Universitas Ahmad Dahlan), apt. Muhammad Ikhwan Rizki, M.Farm (Universitas Lambung Mangkurat), Dr. apt. Yulias Ninik W., M.Si (Universitas Wahid Hasyim), Dr. apt. Maulita Cut Nuria, M.Sc (Universitas Wahid Hasyim), apt. Yance Anas, M.Sc. (Universitas Wahid Hasyim), apt. Risha FillahFithria, M.Sc. (Universitas Wahid Hasyim), apt. Aqnes Budiarti, S.F., M.Sc (Universitas Wahid Hasyim), apt. Ririn Lispita Wulandari, M.Si.Med (Universitas Wahid Hasyim), apt. Maria Ulfah, M.Sc (Universitas Wahid Hasyim), Anita Dwi Puspitasari, S.Si., M.Pd (Universitas Wahid Hasyim), apt. Dewi Andini Kunti Mulangsri, M.Farm. (Universitas Wahid Hasyim), apt. Devi Nisa Hidayati, M.Sc (Universitas Wahid Hasyim), M. Fatchur Rochman, M.Farm (Universitas Wahid Hasyim), apt. Malinda Prihantini, M.Si (Universitas Wahid Hasyim) Redaktur Pelaksana apt. Dewi Andini Kunti Mulangsri, M.Farm Staf Redaksi : apt. Ayu Shabrina, M. Farm apt. Danang Novianto, M.Farm Distributor Imam Asrofi, S.Farm. Alamat Redaksi/Tata Usaha Fakultas Farmasi Universitas Wahid Hasyim Jl. Menoreh Tengah X/22 Sampangan Semarang Telp. 024-8505680, 8505681 Fax. 024-8505680 E-mail: jiffk@unwahas.ac.id Terbit 2 kali setahun sejak September 2004
SYNTHESIS OF COMPLEXES OF DIAZACROWN ETHERS AND TRANSITION METALS AND INVESTEGATION OF THEIR BIOLOGICAL ACTIVITY
Authors: L.Z.Vazirova L.Z.Vazirova
Published: June 2022

vazirova.leyla@gmail.com

The synthesis of diazacrown ethers was carried out using efficient methods. New dibenzoazacrown ethers with functionally substituted hydroxyl and amino groups in the macrocyclic (MC) ring have been synthesized. The structure of the synthesized crown compounds - determined by IR mass NMR, -spectroscopy. Methods for the preparation of transition metal complexes with organic functional ligands based on diazacrown ethers having four, five, and six coordinating atoms in the rings. The synthesized new diazacrown ethers, due to hydroxyl and amino groups, increase the degree of intermolecular interactions and transfer from a two-dimensional structure to a three-dimensional one, which has an increased their biological activity.
Keywords: Crown ethers, transition metals, biological activity,complex.
MODIFIED CONCRETES BASED ON NON-CLINKER BINDERS
Authors: E.F.Aslanov E.F.Aslanov , N.A. Jafarova N.A. Jafarova , T.K. Sherifova T.K. Sherifova
Published: June 2022

The study of the properties of high-strength concrete on the basis of new binders made from technogen waste is discussed. Theoretical provisions for the hardening of a clinker-free binder, consisting of co-crushed dump steel-smelting slag, cullet, a modifying aluminum-containing additive, and an alkaline component hardening under conditions of heat and moisture treatment, have been developed. The optimal compositions of clinker-free binder and fine-grained concrete based on it have been determined. At 25.0 MPa of the activity of the clinker-free binder, the composition contains (metallurgical waste) slag -52%; cullet - 37%; modifying aluminum-containing additive -11%; alkalis (activator) - 7.4% (by weight of the binder). It has been established that to obtain fine-grained concrete grade M 150, it is necessary: 25% clinker-free binder and 75% mixed aggregate, consisting of 35% steel-smelting waste slag and 65% sand. With a water / binder ratio of 0.33.
Keywords: clinker-free cement, waste, modified concrete, metallurgical slag, glass-alkali binder, slag cement.
AMINOMETHOXY DERIVATIVES OF CYCLOHEXANOL
AS BIOCORROSION INHIBITORS
Authors: S.V. Ismayilova S.V. Ismayilova
Published: June 2022

Based on cyclohexanol, aliphatic amines (diethylamine, dipropylamine, dibutylamine, dihexylamine), and formaldehyde, new Mannich bases have been synthesized. The reaction was carried out at a temperature of 78–80°C for 4–5 h in a benzene solution at an equimolar ratio of the starting components. The yield of compounds was 63–80%. The physicochemical data of the synthesized compounds were determined. The composition and structure of the target products were confirmed by elemental analysis, IR, 1H and 13C NMR spectroscopy. Their influence on the vital activity of sulfate-reducing bacteria (SRB) of the "Desulfovibrio desulfuricans" type at three concentrations (25; 50; 100 mg/l) was studied. The resulting compounds showed high bactericidal properties. 1% solutions of these compounds in isopropyl alcohol at a concentration of 100 mg/l showed a 100% bactericidal effect. Given that these aminomethoxy derivatives of cyclohexanol affect bacteria at very low concentrations, they can be proposed as effective inhibitors against sulfate reducing bacteria.
Keywords: cyclohexanol, aliphatic amines, Mannich bases, sulfatereducing bacteria, inhibitor-bactericides, biocorrosion.
HYDROGENATION OF CARBON DIOXIDE ON SIRAL ALUMINOSILICATES MODIFIED WITH COBALT AND PALLADIUM
Authors: Sh.F.Tagiyeva Sh.F.Tagiyeva
Published: June 2022

The reaction of hydrogenation of CO2 in flow mode at atmospheric pressure on Siral aluminosilicates with 1, 10, and 40 wt.% SiO2 and containing Co and Co-Pd has been studied. The synthesized catalysts were characterized by XRD and EPR spectroscopy. It has been established that on catalysts containing only cobalt, at a reaction temperature of ≤ 300oC, practically only methane is formed, and at a reaction temperature of T ≥ 300oC, methane and no more than 1% CO are formed. It is shown that with an increase in the SiO2/Al2O3 ratio, a decrease in the methane yield is observed. The introduction of palladium into the composition of the Co/Siral catalyst stimulates the formation of methanol, the yield of which increases with an increase in the reaction temperature and reaches its maximum value at a reaction temperature of 500°C for the Co,Pd/Siral-10 catalyst. The mechanism of the reaction of CO2 hydrogenation to methanol and the role of palladium in this reaction are discussed.
Keywords: carbon dioxide, hydrogenation, methane, methanol, Siral, Pd, Co.
X-RAY DIFFRACTION STUDY OF BINARY ZINC-OXIDE CATALYSTS
Authors: T.Ch.Taghiyeva T.Ch.Taghiyeva
Published: June 2022

The phase composition of binary zinc-containing catalysts was studied by X-ray diffraction. It was found that the formation of two phases of the initial oxides is observed in all the studied catalytic systems. So, samples of the Zr-Zn-O catalytic system consist of phases of zirconium and zinc oxides, samples of the Ce-Zn-O catalytic system consist of phases of cerium and zinc oxides, while samples of the Mg-Zn-O catalytic system consist of phases of magnesium and zinc oxides. It has been established that the crystallinity of binary zinc-containing catalysts varies in the range from 70% to 89%.
Keywords: X-ray phase analysis, binary catalysts, zinc oxide, cerium oxide, zirconium oxide, magnesium oxide
SEAL PRODUCTS AND THEIR ROLE IN THE PROCESS OF CONVERSION OF ISOBUTENE ON A HIGH SILICA ZEOLITE CATALYST
Authors: I. J. Ahmedova I. J. Ahmedova
Published: June 2022

Conversion of isobutene on a high silica zeolite catalyst in the temperature interval (473-773 K) has been studied. The formation of liquid reaction products is observed at the temperature 473 K, whereas gaseous products form after 523K. Maximum yield of liquid products is observed at the temperature 573 K and makes up 67 %. With increase of contact time the yield of liquid reaction products shifts towards high temperatures. Formation of aromatic hydrocarbons is observed at the reaction temperature higher than 573 K. At the temperature 673 K the main mass of liquid products consists of aromatic hydrocarbons. The activity of H-form of HSZ (HHSZ) in the process of conversion of isobutene in the formation of liquid reaction products occurs only when 6-8% of seal products accumulate on its surface. By the method of ammonia adsorption on the initial and coked catalyst their acidic properties have been studied. It was shown that at the beginning of the process decrease in acidic properties of the catalyst occurs due to accumulation of seal products on it.

Key words: catalyst, activity, isobutene, zeolite, seal products, temperature, heterogen, chromatography, spectroscopy.
Citizens’ Use of eHealth Services During COVID-19 in Relation to National Policy Goals
Authors: Koch Sabine , Vimarlund Vivian
Published: June 2022

The main goals of the Swedish eHealth strategy are to enable citizens to achieve good and equal health and welfare, and to support self-determination and increased participation in society. We analyzed the relationship between these goals and the use of eHealth services offered for citizens prior to and during the COVID-19 pandemic. Data was collected through a national citizen survey issued in 2019 and 2021 to a sample size of 15.000 representative individuals each. Results showed that the use of eHealth services was highest in the 30–49 years age group and among respondents with high education. There were no major differences between respondents with high, medium, or low income, and neither between respondents with different degrees of self-perceived health, nor between native Swedish and non-Swedish respondents. Changes in use of different eHealth services over time were most probably related to the pandemic and are not significant. All age groups showed a similar relative increase regarding their use of eHealth services, except when searching the Internet for diagnosis and treatment where persons above 75 years of age had the largest increase. Most significant were the increase in online visits and the decrease in maintaining health, training, or food diaries. Strategic goals related to equity seem to be partly met as eHealth services are used to the same degree by different socio-economic groups. However, the older population uses eHealth services less than other age groups and a deeper understanding of the relationship between specific services and their impact on strategic goals is needed.
The Implementation of a Participatory Technology Development Process in a Clinical Setting
Authors: Hechtel Nicole , Dürsch Alexander , Prowinsky Peter , Krückeberg Jörn
Published: June 2022

The implementation of a participatory technology development process has been realized within the development of an anti-decubitus system. Nurses as the user group are involved in that process. Beside results, the methodical background and the specific conditions for the realization are presented and discussed.
Blockchain Enabled Patient-Centred Care for Inflammatory Bowel Disease: 4 Principles for Socio-Techical and Clinical Alignment
Authors: Hollingsworth Laura , Wong Ming Chao , Yee Kwang Chien
Published: June 2022

Inflammatory bowel disease (IBD) is a chronic relapsing and remitting illness. The presentation, diagnosis and management IBD are complex, and involve multi-disciplinary care with complex information requirements. The lack of an accurate and comprehensive patient record is often a stumbling block for optimal patient care. Blockchain technology therefore appears to be the perfect solution to improve IBD patient care. Blockchain technology can provide comprehensive and secure data transmission. Many current projects using blockchain for IBD care focus on information delivery. Recently, clinical research has shown that patients have different perceptions of what constitutes high-quality care, compared to healthcare professionals. Patient-centred care in IBD has increasingly taken central stage. Concurrently, blockchain in healthcare has shifted focus to argue for allowing the patient to be in the driver’s seat for information access, facilitated by blockchain-enabled patient-driven interoperability and patient-driven care. This paper dissects the risks and benefits of these two approaches in using blockchain in IBD patient care. This paper then explores the socio-technical and clinical considerations in using blockchain in IBD patient care. Finally, this paper presents four key principles in using blockchain to improve IBD paper care, using collaborative participatory design involving patients, healthcare professionals, and health systems.
Video Recordings of Interactions
Authors: Warth Line Lundvoll
Published: June 2022

Video recordings are an important resource for capturing in-dept social interaction and collaboration in workplace studies. Video-recorded observations can be used to analyse knowledge expansion in collaborative work when practitioners use videoconferences (VCs). Interaction analysis of a problem-solving activity is carried out, pointing to sequences in the work where knowledge expand, and problems are solved. Systematic observations using video recordings provide access to analysis of complex forms of interaction among professionals.
Caregivers Interactions with Clinical Autocomplete Tool: A Retrospective Study
Authors: Zaghir Jamil , Goldman Jean-Philippe , Bjelogrlic Mina , Gaudet-Blavignac Christophe , Lovis Christian
Published: June 2022

Hospital caregivers report patient data while being under constant pressure. These records include structured information, with some of them being derived from a restricted list of terms. Finding the right term from a large terminology can be time-consuming, harming the clinician’s productivity. To deal with this hurdle, an autocomplete system is employed, providing the closest terms after a prefix is typed. While this software application clearly smoothens the term searching, this paper studies the influences of the tool on caregivers’ reporting, inspecting the evolution of their typing conduct over time.
External Validation and Transportability of Models to Predict Acute Kidney Injury in the Intensive Care Unit
Authors: Vagliano Iacopo , Byrne Salsas Carmen , Wünn Tina , Schut Martijn C.
Published: June 2022

External validation of models for the prediction of acute kidney injury (AKI) is rare. We externally validate AKI prediction models in intensive care units. The models were developed on the Medical Information Mart for Intensive Care dataset and validated on the eICU dataset. Traditional machine learning models show limited transportability to the new population (AUROC < 0.8). Models based on recurrent neural networks, which can capture complex relationships between the data, transport well to the new population (AUROC 0.8-0.9). Such models can help clinicians to recognize AKI and improve the outcome.
Analyzing SARS-CoV-2 Sequence Patterns by Semantic Trajectories
Authors: Laddada Wissame , Zanni-Merk Cecilia , Soualmia Lina F.
Published: June 2022

Since the beginning of the pandemic due to the SARS-CoV-2 emergence, several variants has been observed all over the world. One of the last known, Omicron, caused a large spread of the virus in few days, and several countries reached a record number of contaminations. Indeed, the mutation in the Spike region of the virus played an important role in altering its behavior. Therefore, it is important to understand the virus evolution by extracting and analyzing the virus structure of each variant. In this work we show how patterns sequence could be analyzed and extracted by means of semantic trajectories modeling. To do so, we designed a graph-based model in which the genome organization is handled using nodes and edges to represent respectively the nucleotides and sequence connection (point of interest and routes for trajectories). The modeling choices and pattern extraction from the graph allowed to retrieve a region where a mutation occurred in Omicron (NCBI version:OM011974.1).
Federated Learning and Internet of Medical Things – Opportunities and Challenges
Authors: Ali Hazrat , Alam Tanvir , Househ Mowafa , Shah Zubair
Published: June 2022

The recent advancements in artificial intelligence (AI) and the Internet of Medical Things (IoMT) have opened new horizons for healthcare technology. AI models, however, rely on large data that must be shared with the centralized entity developing the model. Data sharing leads to privacy preservation and legal issues. Federated Learning (FL) enables the training of AI models on distributed data. Hence, a large amount of IoMT data can be put into use without the need for sharing the data. This paper presents the opportunities offered by FL for privacy preservation in IoMT data. With FL, the complicated dynamics and agreements for data-sharing can be avoided. Furthermore, it describes the use cases of FL in facilitating collaborative efforts to develop AI for COVID-19 diagnosis. Since handling data from multiple sites poses its challenges, the paper also highlights the critical challenges associated with FL developments for IoMT data. Addressing these challenges will lead to gaining maximum benefit from data-driven AI technologies in IoMT.
Artificial Intelligence-Based Models for Predicting Vaccines Critical Tweets: An Experimental Study
Authors: Shah Uzair , Ali Hazrat , Alam Tanvir , Househ Mowafa , Shah Zubair
Published: June 2022

We studied the suitability of Artificial Intelligence (AI)-based models to predict vaccine-critical tweets on the social media platform Twitter. We manually labeled a sample of 800 tweets as either “vaccine-critical” (i.e, anti-vaccine tweets, mentioned concerns related to vaccine safety and efficacy, and are against vaccine mandates or vaccine passports) or “other” (i.e., tweets that are neutral, report news, or are ambiguous) and used them to train and test AI-based models for automatically predicting vaccine-critical tweets. We fine-tuned two pre-trained deep learning-based language models, BERT and BERTweet, and implemented four classical AI-based models, Random Forest, Logistics Regression, Linear Support Vector Machines, and Multinomial Naïve Bayes. We evaluated these AI-based models using f1 score, accuracy, precision, and recall in three-fold cross-validation. We found that BERTweet outperformed all other models using these measures.
Mental Health Teleconsultation Patterns on the Most Popular mHealth Platforms in Indonesia
Authors: Putri Azzahra Fatinnuha Azmi Prayogi , Marsetyo Farrel Alfaza , Atmaja Umar Surya Kusuma , Fuad Anis
Published: June 2022

Access to telehealth services increased significantly during the COVID-19 pandemic in Indonesia, including for mental health. This study aims to analyze the patterns and variations of mental health teleconsultation (especially for insomnia and depression) on selected Android-based mHealth platforms in Indonesia. We performed 32 teleconsultation sessions on 8 most popular mHealth platforms. About 88% of doctors recommend that patients with depression visit a psychiatrist. On the other hand, 38% of doctors recommended visiting a psychiatrist for insomnia cases. Our findings show differences and similarities in handling depression and insomnia cases in the Indonesian mHealth apps. These variations include case history exploration, clinical decision, and therapeutic. With the growth of telehealth developments, we recommend policy actions and further studies related to the implementation of telehealth in Indonesia.