bluuebunny/crossref_metadata_2025 huggingface dataset:
PELAKSANAAN HAK PELAYANAN KESEHATAN BAGI NARAPIDANA YANG TERJANGKIT COVID-19 DI LEMBAGA PEMASYARAKATAN KELAS II A KENDAL
Authors: Fauziyah Dytia Shafa , Sulistyanta '
Published: May 2023

Abstrak: Penelitian ini bertujuan untuk mengetahui pelaksanaan pelayanan kesehatan bagi Narapidana yang terjangkit Covid-19 di Lembaga Pemasyarakatan Kelas II A Kendal serta hambatan yang dihadapi oleh aparat di Lembaga Pemasyarakatan Kelas II A Kendal. Penelitian ini merupakan penetilian empiris, bersifat deskriptif dengan menggunakan pendekatan kualitatif. Jenis data yang digunakan adalah data primer dan sekunder. Teknik pengumpulan data dilakukan dengan metode penelitian lapangan dan studi pustaka yang dianalisis dengan metode kualitatif dengan metode interaktif. Hasil penelitian menunjukkan bahwa pelaksanaan hak kesehatan terhadap Narapidana yang terjangkit Covid-19 di Lembaga Pemasyarakatan Kelas II A Kendal belum maksimal, dikarenakan tidak semua prosedur dalam Peraturan Menteri Hukum dan HAM RI Nomor M.HH.02.UM.06.04 Tahun 2011 dan Instruksi Direktur Jenderal Pemasyarakatan Nomor PAS-08.OT.02.02 Tahun 2020 belum dilaksanakan dengan baik. Tidak maksimalnya pelaksanaan hak kesehatan tersebut juga dikarenakan adanya beberapa hambatan yang dihadapi oleh Lembaga Pemasyarakatan Kelas II A Kendal, yaitu Lembaga Pemasyarakatan Kelas II A Kendal dalam kondisi overcrowded, terbatasnya SDM tenaga kesehatan, dan kurangnya sarana dan prasarana di dalam Lembaga Pemasyarakatan Kelas II A Kendal.

Kata Kunci: Kesehatan, Narapidana, Covid-19

Abstract: This research aims to describe the implementation of health services for prisoners infected with Covid-19 in second class A Kendal Penitentiary and the obstacles faced by officers at second class A Kendal Penitentiary. This research is an empirical research, descriptive in nature using a qualitative approach. The types of data used are primary and secondary data. Data collection techniques were carried out using field research methods and literature studies which were analyzed using qualitative methods with interactive methods. The results showed that the implementation of health rights for prisoners infected with Covid-19 at the second class A Kendal Penitentiary was not optimal, because not all procedures in the Regulation of the Minister of Law and Human Rights of the Republic of Indonesia Number M.HH.02.UM.06.04 of 2011 and the Director's Instructions General of Corrections Number PAS-08.OT.02.02 of 2020 has not been implemented properly. The non-optimal implementation of the right to health is also due to several obstacles faced by the second class A Kendal Penitentiary second class A Kendal Penitentiary in an overcrowded condition, limited human resources for health workers, and the lack of facilities and infrastructure within the second class A Kendal Penitentiary.
Keywords: Health, Prisoners, Covid-19
PENERAPAN RESTORATIVE JUSTICE DALAM PENYELESAIAN TINDAK PIDANA KEKERASAN SEKSUAL TERHADAP ANAK DI KABUPATEN MAGETAN
Authors: Caesari Diyariesta , Subekti '
Published: May 2023

Abstrak: Kajian  ini  menelaah  tentang  penerapan  restorative  justice  dalam  penyelesaian  tindak  pidana kekerasan  seksual  terhadap  anak  di  Kabupaten  Magetan.  Metode penelitian yang dipakai yaitu metode penelitian empiris bersifat deskriptif. Pendekatan perundang-undangan (statute approach) serta pendekatan kasus (case approach) yang digunakan peneliti adalah Pendekatan pada penelitian normatif dimana peneliti mencoba membentuk argumentasi aturan pada perspektif perkara konkrit yang terjadi dilapangan, tentunya perkara tadi erat kaitannya dengan perkara atau peristiwa aturan yang terjadi di lapangan. hasil dari penelitian ini antara lain penerapan restorative justice dalam tindak pidana kekerasan seksual terhadap anak dapat memberikan nilai yang adil bagi kedua belah pihak dan dapat memenuhi hak-hak anak yang seharusnya diperoleh menurut Undang-Undang Nomor 23 Tahun 2002 sebagaimana telah diubah dengan Undang-Undang Nomor 35 Tahun 2014 dan Undang-Undang Nomor 17 Tahun 2016 tentang Perlindungan Anak.

Kata Kunci: Tindak Pidana; Restorative Justice; Kekerasan Seksual; Hak-hak Anak.

 

Abstract: This study examines the application of restorative justice in the settlement of criminal acts of sexual harrasment against children in Magetan. The research method used is descriptive empirical research method. The legal approach (statute approach) and the case approach used by the researcher is an approach to normative research where the researcher tries to form a rule argument from the perspective of a concrete case that occurs in the field, of course, the case is closely related to the case or regulatory event that occurred in the field. The results of this study include the application of restorative justice in criminal acts of sexual violence against children can provide a fair value for both parties and can fulfill the rights of children that should be obtained according to Law Number 23 of 2002 as amended by Law Number 35 of 2014 and Law Number 17 of 2016 concerning Child Protection.
Keywords: Criminal Act; Restorative Justice; Sexual Harrasment; Children’s Rights
FAKTOR YANG MENDORONG PENYALAHGUNAAN OBAT KERAS UNTUK TUJUAN ABORSI DI KABUPATEN SRAGEN
Authors: Wira U Oga Yudha , Ginting Rehnalemken
Published: May 2023

Abstrak
Penelitian ini bertujuan untuk mengetahui faktor apa saja yang mendorong tindak pidana  penyalahgunaan obat keras untuk tujuan aborsi serta penegakan hukum terhadap penyalahgunaan obat aborsi yang ada di kabupaten sragen terkait maraknya peredaran obat keras jenis Cytotec di internet yang disalahgunakan untuk menggugurkan kandungan. Jenis Penelitian yang dipergunakan dalam penelitian ini yaitu menggunakan metode penelitian empiris, metode empiris yaitu dengan observasi atau penelitian secara langsung wawancara dan studi dokumentasi secara langsung ke lapangan guna mendapatkan data. Sehingga dapat mengetahui faktor pendorong tindak pidana penyalahgunaan obat keras dan proses penegakan hukum beserta hambatan yang dialami Kepolisian Resor Sragen terkait penyalahgunaan obat. Penyalahgunaan obat keras dengan tujuan menggugurkan kandungan merupakan Tindakan pidana, penggunaan obat jenis Cytotec tidak boleh sembarangan,. Proses mendapatkannya pun harus melalui prosedur yang sudah ditetapkan oleh undang-undang. Obat Cytotec tergolong Obat Daftar G yaitu obat keras, karena mengandung zat misoroptol yang berbahaya  terhadap janin dan ibu hamil. Oleh sebab itu penulis menganggap perlunya penulisan hukum untuk  mengetahui faktor penyebab penyalahgunaan dan penegakan hukumnya beserta hambatan yang dialami kepolisian
Kata kunci : Faktor Pendorong, Penyalahgunaan Obat, Aborsi

Abstract
This study aims to determine what factors drive the abuse of hard drug abuse for abortion purposes as  well as law enforcement against abortion drug abuse in Sragen district related to the rampant circulation of Cytotec type of hard drugs on the internet that are misused for abortion. This type of research used in this study is to use empirical research methods, the empirical method is by direct observation or research interviews and documentation studies directly to the field in order to obtain data. So that they can find out the driving factors behind the misuse of hard drugs and the process of law enforcement along with the obstacles experienced by the Sragen District Police regarding drug abuse. Misuse of hard drugs with the aim of aborting the womb is a criminal act. The process of obtaining them must go through procedures set out in the law. Cytotec drugs are classified as List G drugs, which are hard drugs, because they contain misoroptol which is dangerous to the fetus and pregnant women. Therefore the authors consider the need for legal writing to find out the causes of misuse and law enforcement along with the obstacles experienced by the police
Keywords : Driving Factor, Drug Abuse, Abortion
Drought tolerance enhancment in cotton (Gossypium hirsutum L.) by mepiquate chloride seed priming
Authors: Shahrbano Gafouri
Published: May 2023

To study pre-sowing seed treatment (seed priming) of hormone Mepiquat chloride (MC) (PIX) on physiological properties and increase drought tolerance in cotton (Shayan cultivar), a factorial experiment was performed in a completely randomized design with 3 replications. In this research, the seeds were initially exposed to two doses of the growth-regulatory hormone mepiquat chloride, including 5 and 10 g/l and control before being planted in pots.After the emergence of the plant from the soil, dry treatments based on the soil field capacity (FC) at three levels of irrigation at 25, 50, and 100% of field capacity for six weeks are applied to them, and growth indices, the activity of antioxidant enzymes, amount of hydrogen peroxide and malondialdehyde as well as changes in the two hormones of abscisic acid and endogenous gibberellin was investigated. According to the results of this research, the effect of seed priming with PIX and the interaction of drought × pre-sowing seed treatment on all physiological traits were significant at the level of 1%. The results of experimental data showed that drought stress (especially severe drought) reduced most growth indicator and physiological traits (fresh and dry weight of root and shoot, shoot length, fresh and dry weight of leaf, leaf area, root peroxidation activity, leaf phenol content, amount of gibberellin ) and only increased abscisic acid content (74%), root diameter (38%), root length(14%), leaf thickness, (15%) compared to the control. pre-sowing seed treatment with PIX, while increasing the dry weight (28% roots and 34% leaves) and thickness roots (58%) and 96% leaves (96%), increased catalase (88%) and peroxidase (6%) activity and abscisic acid content (73%) of leaves, reduced hydrogen peroxide (17%), malondialdehyde (20%) of leaves, and gibberellin (40%) of roots. Under extreme drought stress, the application of PIX decreased the amount of phenolic compounds in leaves by 44% as compared to the control. The interplay of drought stress × PIX decreased root gibberellin by 25% and raised leaf abscisic acid by 183%. According to the study results, seed priming with PIX improved the physiological and biochemical responses of cotton under drought conditions
Effects of Hexythiazox on Different Stages of Mites Infesting Orange Trees
Authors: Alhewairini Saleh S.
Published: May 2023

Miticidal action of hexythiazox has been investigated against three mites, Citrus Rust Mite, Phyllocoptruta oleivora (Ashmead) (Acari: Eriophyidae), False Spider Mite, Brevipalpus californicus (Banks) (Acari: Tenuipalpidae) and Citrus Brown Mite, Eutetranychus orientalis Klein (Acari: Tetranychidae), infesting citrus trees in the region of Al Qassim, Saudi Arabia. Three concentrations of hexythiazox, half of the recommended dose (HRD), the recommended dose (RD) and double recommended dose (DRD) were used against the selected mite species at immature and adult stages. Mortality data was recorded after regular intervals of a day till seven days of post-treatment application. Larvicidal action of the pesticide was observed in terms of post spray percentage of egg hatching. Trails regarding mortality of immature and adult mites were carried out under laboratory and field conditions. A maximum of 72.88% and 64.41% mortality was observed in immature mites of P. oleivora at RD under laboratory and field conditions respectively. The highest mortality of adult mites at RD was recorded again in P. oleivora that was 18.97 and 20.39% under laboratory and field conditions respectively, showing that mortality percentage was insignificant in adults. Under the same conditions, mortality of mites observed at HRD was non-significant and there was negligible increase in mortality when concentration was increased from RD to DRD. Success of hatching for the treated eggs of the three selected mites was observed in the range of 5.00 to 12.50% at the recommended dose. This indicated that hexythiazox has the significant potential of inhibiting hatching process. For the successful control over citrus mites, the appropriate time of spray is prehatching stage
IKKα kinase coordinates BRD4 and STAT3 signaling to subvert DNA damage-based anticancer therapy
Authors: Pecharroman Irene , Sole Laura , Villanueva Daniel Alvarez , Bertran Joan , Guillén Yolanda , Lobo Teresa , Alonso-Marañon Josune , Martínez Maria , García-Hernández Violeta , Gimenez Gemma , Colomer Carlota , Mulero María Carmen , Gonzales Jessica , Salazar Ramon , Santos Cristina , Garrido Marta , Villanueva Alberto , Borràs Eva , Sabidó Eduard , Bonfill-Teixidor Ester , Iurlaro Raffaella , Montoto Angela , Seoane Joan , Iglesias Mar , Bigas Anna , Espinosa Lluis
Published: May 2023

Activation of the IKK kinase complex has recurrently been linked to colorectal cancer (CRC) initiation and progression. However, identification of downstream effectors other than NF-kB has remained elusive.
Analysis of IKK-dependent substrates after UV-treatment revealed that BRD4 phosphorylation by IKKa is required for chromatin-binding dynamics upon damage. Moreover, IKKa induces the NF-kB-dependent transcription of LIF leading to STAT3 activation, association of BRD4 to STAT3 and recruitment to specific target genes. IKKa abrogation results in defective BRD4 and STAT3 function leading to irreparable DNA damage and apoptotic cell death upon different stimuli. Simultaneous inhibition of BRAF-dependent IKKa activity and JAK/STAT pathway enhanced the therapeutic potential of 5-FU plus irinotecan in CRC patient-derived organoids and is curative in a chemotherapy-resistant CRC xenograft model. Coordinated expression of LIF and IKKa is a poor prognosis marker for CRC patients.
Our data uncover a functional link between IKKa, BRD4 and JAK/STAT signaling with clinical relevance.
Suicidality, depression, and anxiety among Hong Kong veterinarians: a quantitative pilot study
Authors: Chan Camille K.Y. , Wong Paul W.C.
Published: May 2023

Objective
The suicidality and poor mental health conditions of the veterinary profession have drawn increasing attention; however, little is known about the mental health status of veterinarians in Hong Kong. This study aimed to examine the prevalence of suicidality and symptoms of depression and anxiety among Hong Kong veterinarians.
Methods
All veterinarians were registered and practising in Hong Kong at the time of recruitment to the e-survey study between 1 January 2022 and 31 March 2022. Participants’ suicidality, depressive symptoms, and anxiety symptoms were assessed using validated scales.
Results
Data from 56 participants were included in the analysis. Among them, 22.0% self-reported as at risk of suicide, 19.6% had current suicidal ideation, 29.4% had depressive symptoms, 29.4% and anxiety symptoms, and 23.5% were comorbid with depression and anxiety. Our findings were comparable to or higher than those reported in Anglophone and European countries.
Conclusion
Contextual factors affecting the mental health of veterinarians practising in Hong Kong are worth further investigation. It is important to enhance mental health awareness by improving the profession’s mental health literacy as a suicide prevention strategy.
Sixteen-year longitudinal evaluation of blood-based DNA methylation biomarkers for early prediction of Alzheimer’s disease
Authors: Hackenhaar Fernanda Schäfer , Josefsson Maria , Adolfsson Annelie Nordin , Landfors Mattias , Kauppi Karolina , Porter Tenielle , Milicic Lidija , Laws Simon M. , Hultdin Magnus , Adolfsson Rolf , Degerman Sofie , Pudas Sara
Published: May 2023

Background: DNA methylation (DNAm), an epigenetic mark reflecting both inherited and environmental influences, has shown promise for AD prediction.
Objective: Testing long-term predictive ability (>15 years) of existing DNAm-based epigenetic age acceleration (EAA) measures and identifying novel early blood-based DNAm AD-prediction biomarkers.
Methods: EAA measures calculated from Illumina EPIC data from blood were tested with linear mixed-effects models (LMMs) in a longitudinal case-control sample (50 late-onset AD cases; 51 matched controls) with prospective data up to 16 years before clinical onset, and post-onset follow-up. Novel DNAm biomarkers were generated with epigenome-wide LMMs, and Sparse Partial Least Squares Discriminant Analysis applied at pre- (10-16 years), and post-AD-onset time-points.
Results: EAA did not differentiate cases from controls during the follow-up time (p-values>0.05). Three new DNA biomarkers showed in-sample predictive ability on average 8 years pre-onset, after adjustment for age, sex, and white blood cell proportions (p-values: 0.022-< 0.00001). Our longitudinally-derived panel replicated nominally (p=0.012) in an external cohort (n=146 cases, 324 controls). However, its effect size and discriminatory accuracy were limited compared to APOEε4-carriership (OR=1.38 per 1 SD DNAm score increase vs. OR=13.58 for ε4-allele carriage; AUCs=77.2% vs. 87.0%). Literature review showed low overlap (n=4) across 3275 AD-associated CpGs from 8 published studies, and no overlap with our identified CpGs.
Conclusions: The limited predictive value of EAA for AD extends prior findings by considering a longer follow-up time, and with appropriate control for age, sex, APOE, and blood-cell proportions. Results also highlight challenges with replicating discriminatory or predictive CpGs across studies.
Development and application of a quantitative index for predicting unsafe behavior of shop floor workers integrating cognitive failure reports and best worst method
Authors: Shakerian Mahnaz , Choobineh Alireza , Jahangiri Mehdi , Alimohammadlou Moslem , Hasanzadeh Jafar , Nami Mohammad
Published: May 2023

The reliability of shop floor workers, mostly as the last level of a socio-technical system, has been identified as an essential factor in complex systems. This study aimed to develop and apply a quantitative and applicable method to help safety practitioners to manage unsafe behavior in industrial systems. This work is a descriptive-analytical and cross-sectional study, which was conducted in an Iranian manufacturing company. A questionnaire with six main unsafe behavior scales was used to determine the participants’ unsafe behavior scores. Since the effect of each of the six scales on unsafe behavior occurrence was different, the scales were weighted using best-worst method (BWM). Finally, to determine a quantitative score for unsafe behavior of the workers, the total unsafe behavior index (USBItotal) score was computed. The maximum and minimum mean scores were 10.68 and 5.09 for routine violations (RVs) and exceptional violations (EVs), respectively. The present study introduced an innovative proactive tool to provide safety practitioners with a practical hint using a quantitative cost-effective accessible method for predicting cognitive unsafe behavior of shop floor workers.
Evolution of Multicomponent [Pd2ABCD] Cages
Authors: Wu Kai , Benchimol Elie , Baksi Ananya , Clever Guido
Published: May 2023

Self-assembled hosts, inspired by biological receptors and catalysts, show potential for sustainable synthesis, energy conversion and medicine. Implementing multiple functionalities in the form of distinguishable building blocks, however, is difficult without risking narcissistic self-sorting or statistical mess. We report a systematic series of integratively self-assembled heteroleptic cages in which two square-planar PdII cations are bridged by four different bis-pyridyl ligands A, B, C and D via synergistic effects to form a single isomer of lantern-shaped cage [Pd2ABCD] as exclusive product. This ultimate self-sorting goal, forming just one out of 55 possible structures, is reached under full thermodynamic control and can be realized progressively (by combining progenitors such as [Pd2A2C2] with [Pd2B2D2]), directly from ligands and PdII cations, or by mixing all four corresponding homoleptic cages. The rational design of complex multicomponent assemblies, allowing to incorporate chemical moieties in a modular approach, will advance the application level of functional nanosystems.
Modeling policy pathways to maximize renewable energy growth and investment in Democratic Republic of the Congo using OSeMOSYS
Authors: Dalder Jacob , Oluleye Gbemi , Yeganyan Rudolf , Tan Naomi , Cannone Carla , Howells Mark
Published: May 2023

Keeping global warming from evolving into irreversible climate disaster requires immediate and sustained decarbonization of global energy systems. Of urgent priority are the energy systems in low- and middle-income countries (LMICs) where billions of people are projected to gain energy access in the next several decades. Therefore, leapfrogging traditional fossil fuel-based electricity production in favor renewable energy technologies is a critical issue area for sustainability. In the Democratic Republic of the Congo, political and economic challenges mean $44B in external investment is required to achieve its 2030 emissions reduction targets. Additionally, RETs are often more expensive.
This study sought to generate, evaluate, and recommend possible national policies for the DRC government to implement to most effectively boost growth and investment in RETs. Financial incentives were identified as the policy type most practical for DRC. Modeling the resulting energy systems for policy pathways involving a 16% RET subsidy, a 70% fossil fuel tax, and both in combination relative to no-policy baseline scenarios, the scenarios including the tax had the lowest net costs and the highest proportion of RETs (above 90%). Additionally, despite current reliance on hydropower to fulfill 98% of its energy needs, hydropower plays a very minor role in all modeled scenarios. Finally, a post-modeling market potential assessment was performed on the technology that dominated off-grid supply across policy pathways: the 0.3 kW small solar home system (SHS). Based on learning rates for solar PV, demand for the small SHS system in DRC (>160 million units in total) was found to be sufficient to substantially reduce the unit cost as deployment scales.
Putting results into context, emissions reductions for the policy pathways were higher than a past study focused on distributed RETs in DRC, and system costs were 15% higher than estimated in other analysis. These results provide a novel contribution to the literature by demonstrating how financial incentive policies can influence RET uptake in DRC specifically. Ultimately, this study yielded four policy recommendations for the DRC government:
1. Pursue financial incentives to catalyze DRC’s renewable energy supply
2. Tax fossil fuel energy production
3. Re-evaluate focus on hydropower
4. Promote DRC as a healthy market for solar home systems
Knowledge of Obstetric Danger Signs and Birth Preparedness and Complications Readiness among Mobile Pokot Nomadic Pastoralists’ Pregnant Women in Tiaty Sub-County, Baringo County-Kenya
Authors: KIPTULON EVANS Kasmai , Orsolya Mate
Published: May 2023

Problem: Maternal mortality in Kenya remains unacceptably high. Mobile pastoralists communities, Pokot included take the greatest burden of these maternal deaths.Background Knowledge of obstetric danger signs is important for prevention of pregnancy and birth complications as it influences pregnant women to prepare for birth and complications.Aim To assess the level of knowledge of obstetrics danger signs and its effect on Birth Preparedness and complications Readiness among mobile Pokot nomadic pastoralists in Kenya.Methods A descriptive cross-sectional study was conducted among 275 Pokot nomadic pastoralists’ pregnant women using a multistage sampling technique. Chi square (X2) was used to test the association between categorical variables and a P-value of < 0.05 was considered significant.Findings: Majority of the women had high knowledge of obstetric danger signs. However, the level of Birth Preparedness and complication readiness was low.Discussion Knowledge of obstetric danger signs and birth preparedness and complication readiness remains a key subject in fight against maternal mortality especially in pastoralists and unsettled communities where services are unpredictable and disrupted by frequent movements.Conclusion Maternal mortality, which remains a major reproductive health concern in Kenya may be reduced through government and other stakeholders deliberate delivery of quality antenatal care targeting mobile Pokot and other pastoralists living in Kenya.
Are high frequency marsquakes caused by meteoroid impacts? Implications for a seismically determined impact rate on Mars
Authors: Zenhäusern Géraldine , Wojcicka Natalia , Stähler Simon , Collins Gareth , Daubar Ingrid , Knapmeyer Martin , Ceylan Savas , Clinton John , Giardini Domenico
Published: May 2023

The crater density on planetary surfaces is used to determine their ages throughout the solar system, which requires a model for the rate of meteorite impacts of different sizes. For craters smaller than 30 meters, this rate has been observed from the generation of new craters in repeated orbital images. For larger craters, the rate was extrapolated from the lunar surface ages, taking into account the atmospheric removal of small craters. It has been observed that both estimates do not match for crater diameters smaller than 30 meters. The NASA InSight seismometer SEIS provided a new independent constraint, when it recorded seismic signals of several impacts during its mission. These confirmed impacts are part of a larger class of marsquakes (Very High Frequency, VF), all of which have characteristics consistent with an impact origin. We show that these VFs are plausibly caused by meteorite impacts and derive the impact rate required to explain their numbers. An empirical scaling relationship is used to convert between seismic moment and crater diameter. We apply area and time corrections to derive a global impact rate and find that the derived rate is 210--290 craters >8m globally per year, consistent with previously published chronology model rates and above the rates derived from freshly imaged craters.
Identification of the trade-off between speed and efficiency in undulatory swimming using a bio-inspired robot
Authors: Anastasiadis Alexandros , Paez Laura , Melo Kamilo , Tytell Eric , Ijspeert Auke Jan , Mulleners Karen
Published: May 2023

Anguilliform swimmers, like eels or lampreys, are highly efficient swimmers. Key to understanding their performances is the relationship between the body's kinematics and resulting swimming speed and efficiency. But, we cannot prescribe kinematics to living fish, and it is challenging to measure their power consumption. Here, we characterise the swimming speed and cost of transport of a free-swimming undulatory bio-inspired robot as we vary its kinematic parameters, including joint amplitude, body wavelength, and frequency. We identify a trade-off between speed and efficiency. Speed, in terms of stride length, scales with the maximum tail angle, described by the newly proposed specific tail amplitude and reaches a maximum value around the specific tail amplitude of unity. Efficiency needs a whole-body motion, travelling wave-like kinematics, and lower specific tail amplitudes. Our results suggest that live eels choose efficiency over speed and provide insights into the key characteristics affecting undulatory swimming performance.
Next-LSTM: A novel LSTM-based Image Captioning technique
Authors: Singh Priya , Kumar Chandan , Kumar Ayush
Published: May 2023

Recently, Image Captioning has evolved into an immensely popular area in the field of Computer Vision. It strives to generate natural language sentences in order to describe the salient parts of a given image. Research in this area is active and various Machine learning-based Image Captioning models have been proposed in the literature. The main challenge with the existing approaches is effectively extracting image features to generate adequate image captions. Further, there is a need to improve the generalizability of the results on large and diverse datasets. In the current paper, a novel method framework, namely Next-LSTM is proposed for Image Captioning. It first extracts the image features using ResNeXt. It is a powerful convolution neural network-based model that is adopted for the first time in the Image Captioning domain. Later, it applies a Long-short term memory network on the extracted features to generate accurate captions for the images. The proposed framework is then evaluated on the benchmark Flickr-8k dataset on Accuracy. The performance of the proposed framework is also compared to the state-of-the-art approaches and it outperforms the existing approaches.
Vermicompost as an Alternative Substrate to Peat Moss for Strawberry (Fragaria Ananassa) in Hydroponic Culture
Authors: YEGANEH MAHSA AZIZI , SHAHABI ALI ASGHAR , EBADI ALI , ABDOOSI VAHID
Published: May 2023

Background: Consecutive droughts and quantitative and qualitative reduction of surface and underground water resources have caused an increase in greenhouse and hydroponic cultivation for most garden crops, including strawberries, in Iran. On the other hand, most of the inputs of greenhouse crops in Iran are imported. To possibility of replacing vermicompostwith peat moss under hydroponic cultivation, an experiment was done in a split plot based on randomized complete blocks design in three replications in Isfahan (Iran) Agricultural and Natural Resources Research Center in 2019. The main treatment was substrate at four levels included different levels of vermicompost (30 and 50%) and peat moss (30 and 50%) in combination with perlite and sub-treatment were Selva and Camarosa cultivars.
Results: The results showed that Camarosa in 50% perlite/ 50% peat moss and Selva in 50% perlite / 50% peat moss and 70% perlite /30% vermicompost had maximum yield.
Leaf number, chlorophyll index were the highest in Camarosa cultivar in peat moss substrates. Strawberry cultivars had the highest amount of root fresh weight, vitamin Cand soluble solids in substrates containing vermicompost. Camarosa in 50% perlite/ 50% peat moss and Selva in 50% perlite /50% vermicompost had maximumroot dry weight. Also The highest number of inflorescences was related to substrates containing peat moss and 70% perlite / 30% vermicompost. Maximum amount of fresh and dry weight of shoots were observed in 70% perlite/30% peat moss. Selva cultivar had more inflorescences (16.5%) than Camarosa and Camarosa cultivar produced more fresh and dry weight of shoots (16.5%, 23.01%) than Selva.
Conclusion:Both strawberry cultivars in vermicompost and peat moss beds were slightly different from each other, even in traits such as TSS, vitamin C, and root fresh weight, vermicompost was better than peat moss, so since vermicompost is more cost-effective and affordable compared to peat moss, so a slight reduction in some traits in vermicompost in comparison with peat moss, it is justified and can be recommended as an alternative to peat moss in Selva and Camarosacultivar.
Research trends on the relationship between air pollution and cardiovascular diseases in 2013-2022 – A scientometric analysis
Authors: Zheng Daitian , Yang Qiuping , Wu Jinyao , Tian Huiting , Ji Zeqi , Chen Lingzhi , Cai Jiehui , Li Zhiyang , Chen Yexi
Published: May 2023

Exposure to air pollution is linked with an elevated risk of cardiovascular diseases (CVDs) and CVDs-related death. Despite the increasing concern over this issue, there is a shortage of scientometric analysis on the subject in existing databases. Therefore, we propose a scientometric study to explore research hotspots and directions in this topical field over the past decade. The present study employed the core collection of Web of Science (WoS) to obtain all relevant publications. Subsequently, Excel, the Bibliometix R-package, CiteSpace, and VOSviewer were utilized to analyze literature information, encompassing but not limited to annual publications, highly cited papers and co-cited references, journals, authors, countries, organizations, and keywords. Research on air pollution and CVDs has remarkable increase over the past decade. The top researchers are Kan H, Brook RD, Peters A, and Schwartz J. The 3144 articles were published by 4448 institutions in 131 countries/regions. The leading countries are the USA and China. Environmental Research was the most published journal. Mortality, hospital admissions, oxidative stress, inflammation, long-term exposure, fine particulate matter, and PM2.5 are the top areas that merit further investigation and hold significant potential for advancing our understanding of the complex relationship between air pollution and CVDs.
Integrating Accompanying Patients into Clinical Oncology Teams: Limiting and Facilitating Factors
Authors: Pomey Marie-Pascale , Paquette Jesseca , Nelea Monica Iliescu , Vialaron Cécile , Mourad Rim , Bouchard Karine , Normandin Louise , Côté Marie-Andrée , Desforges Mado , Pomey-Carpentier Pénélope , Fortin Israël , Ganache Isabelle , Régis Catherine , Rosberger Zeev , Charpentier Danielle , Vachon Marie-France , Bélanger Lynda , Dorval Michel , Ghadiri Djahanchah P. , Lavoie-Tremblay Mélanie , Boivin Antoine , Pelletier Jean-François , Fernandez Nicolas , Danino Alain M. , de Guise Michèle
Published: May 2023

Objectives
Since 2018, four establishments in Quebec have been instrumental in implementing the PAROLE-Onco program, which introduced accompanying patients (APs) in healthcare teams to improve cancer patients’ experience. APs are patient advisors who have acquired specific experiential knowledge related to living with cancer, using services, and interacting with healthcare professionals. They are therefore in a unique and reliable position to be able to provide emotional, informational, cognitive and navigational support to patients dealing with cancer. We aimed to explore APs’ perspectives regarding the limiting and facilitating factors in terms of how they are integrated into the clinical oncology teams.
Methods
A qualitative study based on semi-structured interviews and focus groups was conducted with 20 APs at the beginning of their intervention (T1) and two years afterwards (T2). Limiting and facilitating factors of APs’ integration into clinical teams were analyzed in terms of governance, culture, resources and tools.
Results
The most significant limiting factors raised by APs to be integrated into clinical teams were: governance involvement, organizational boundaries, team members' availabilities, and confusion about the specific roles played by APs. Communication challenges were also raised, leading to inadequate promotion of the program to patients. The lack of time, space and compensation were also mentioned as limiting factors. Creating opportunities for team members to meet APs, building trust and teaching team members how APs’ activities are complementary to theirs were enhancing factors. Other facilitators include APs being involved in decision-making committees, being leaders in the PAROLE-Onco program promotion to patients and clinical team members and creating opportunities to communicate with team members to help enhance their work and provide feedback to improve patient services. Awareness of APs’ added value for the team and patients is also a key facilitator. Regarding tools, offering accompanying services by telephone allows both patients and APs to benefit from the flexibility they need.
Conclusion
Over time, APs were able to identify the best factors for successful implementation. Recommendations include APs and professionals working in co-construction on organization, leadership, resources, and status factors. This could help catalyze a change in culture within health establishments and allow people dealing with cancer to benefit from the experiential knowledge of other patients within their clinical team.
Phase II Clinical Trial to Study the Safety and Efficacy of Combined S-1 + Oxaliplatin Therapy as Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer in Older Patients
Authors: Ota Mitsuhiko , Saeki Hiroshi , Uehara Hideo , Matsuda Yoshiko , Tsutsumi Satoshi , Kusumoto Tetsuya , Yasui Hisateru , Ubukata Yasunari , Yamaguchi Shohei , Orita Hiroyuki , Izawa Naoki , Kakizoe Saburo , Shimokawa Mototsugu , Yoshizumi Tomoharu , Kakeji Yoshihiro , Mori Masaki , Oki Eiji
Published: May 2023

Background: Gastrectomy with D2 dissection and adjuvant chemotherapy is the standard treatment for locally advanced gastric cancer (LAGC) in Asia. However, administering chemotherapy with sufficient intensity after gastrectomy is challenging. Several trials demonstrated the efficacy of neoadjuvant chemotherapy (NAC). However, only few studies explored the feasibility of NAC-SOX for older patients with LAGC. This phase II study (KSCC1801) evaluated the safety and efficacy of NAC-SOX in patients aged ≥70 years with LAGC.
Methods: Patients received three cycles of SOX130 (oxaliplatin 130 mg/m2 on day 1, oral S-1 40–60 mg twice daily for 2 weeks every 3 weeks) as NAC, followed by gastrectomy with lymph node dissection. The primary endpoint was the dose intensity (DI). The secondary endpoints were safety, R0 resection rate, pathological response rate (pRR), overall survival, and relapse-free survival.
Results: The median age of 26 enrolled patients was 74.5 years. The median DI in NAC-SOX130 was 97.2% for S-1, and 98.3% for oxaliplatin. Three cycles of NAC were performed in 25 patients (96.2%), of whom 24 (92.3%) underwent gastrectomy with lymphadenectomy. The R0 resection rate was 92.3% and the pRR (≥grade 1b) was 62.5% (95% CI: 40.6–81.2). The major adverse events were neutropenia (20.0%), thrombocytopenia (11.5%), anorexia (11.5%), nausea (7.7%), and hyponatremia (7.7%). Postoperative complications of abdominal infection, elevated blood amylase, and bacteremia occurred in one patient each. Severe diarrhea and dehydration caused one treatment-related death.
Conclusions: NAC-SOX130 is feasible therapy in older patients, although systemic management and careful monitoring of adverse events are necessary.
Characterization of historical megathrust earthquake ruptures in Central Chile using logic tree analysis
Authors: Martin Javiera San , Calisto Ignacia , Quezada Jorge , Stewart Daniel , Ely Lisa , Cifuentes-Lobos Rodrigo , Moreno Marcos
Published: May 2023

Characterizing the spatial distribution of ruptures from historical and recent earthquakes is key to understanding the seismic cycle of large earthquakes in subduction zones, and thus to assessing the potential risks associated with future earthquakes. Central Chile (35$^{\circ}$S-38$^{\circ}$S) has been continuously affected by large earthquakes, such as the 2010 Maule (Mw 8.8) and the 1835 earthquakes witnessed by Robert Fitzroy (HMS Beagle captain). Here, we identify the rupture pattern and tsunami propagation of the 1751, 1835, and 2010 mega-earthquakes, events that overlapped in central Chile, by compiling historical records and applying robust statistical tools. We used an adaptation of a logic tree methodology to generate random sources of slip distribution for each event, constrained by tsunami and deformation data. We find that the three events studied have different slip peaks. The 1751 earthquake has the largest slip with a maximum patch of $\sim$ 26 m, while the 2010 and 1835 earthquakes reach slips of $\sim$ 16 m and $\sim$ 10 m, respectively. Our results show that a part of the segment between 36$^{\circ}$S and 37$^{\circ}$S was consistently affected by large earthquakes, but with different slip and depth. The northern part of the segment accumulated energy for at least 300 years and was released by the 2010 earthquake. This work provides important information for identifying rupture patterns between historical and recent earthquakes, and highlights the importance of extending the time scale of earthquake slip distribution analyses to multiple cycles to describe both earthquake characteristics and their spatial relationship, and thus gain a better understanding of seismic hazard.
GPRC Molecular Dynamics Forecasting using Recurrent Neural Networks
Authors: López-Correa Juan Manuel , König Caroline , Vellido Alfredo
Published: May 2023

G protein-coupled receptors (GPCRs) are a large super-family of cell membrane proteins that play an important physiological role as transmitters of extra-cellular signals.Signal transmission through the cell membrane depends upon conformational changes in the transmembrane region of the receptor, which makes the investigation of the dynamics in these regions particularly relevant.Molecular dynamics simulations can provide information about the conformational states of the receptor at the atom level and Machine Learning methods can be useful tools for knowledge discovery from this information.
In this paper, Recurrent and Convolutional Neural Networks are used to predict the molecular dynamics of GPCRs in different conformations, using the \textbeta 2AR GPRC as an illustration of the process and focusing on specific receptor regions.Active and inactive states of the GPRC are analysed in six scenarios involving APO, Full Agonist (BI-167107) and Partial Inverse Agonist (carazolol) of the receptor. Three Machine Learning models with increasing complexity in terms of neural network architecture are evaluated and their results compared.Results show that the transmembrane helices are the regions whose dynamics are best predicted by these models.
Evaluation of the management of COVID-19 patients by general practitioners in France during the pandemic: how were best practices recommendations implemented?
Authors: Lutaud Romain , Fierling Thomas , Forte Jenny , Verger Pierre , tardieu sophie , toledano guillaume , gentile stephanie
Published: May 2023

Background: Since the first wave of COVID-19 in December 2019 general practitioners (GP) have had to be adaptive and to regularly update their practices.
This study aimed to assess GP practices in the management of adult patients with COVID-19 in the outpatient setting in France, and to describe GP difficulties in implementing related health authority recommandations, with a view to identifying areas for improvement.
Methods: A clinical audit was conducted on a sample of GP practicing in the Provence-Alpes-Côte d'Azur region in southeast France. Recruitment took place between March and June 2021 using a network sampling method until data saturation. Only GP who had treated more than 20 COVID-19 patients were included.
Results: The majority of GP (85.7%) stated that they had continuously adapted their COVID-19 management practices as updated recommendations were published. In contrast, the majority reported that they had not adapted their pratices to the specific needs of at-risk populations (i.e., people over 80 years old, those with stage B cirrhosis, immunocompromised patients, and women in the third trimester of pregnancy). Furthermore, clinical signs of COVID-19 specific to people over 80 years old were poorly known.
Conclusions: Despite rapidly evolving recommendations, and the fact that outpatient management is a major tool for reducing hospital burden, no study to date has investigated the clinical management of COVID-19 in the outpatient sector. Our study, conducted using a clinical audit, highlights the need to ensure GP are more aware of at-risk patients, the population most associated with hospital burden. This type of evaluation should be integrated into future epidemic crisis responses to ensure the implementation and dissemination of best practice recommendations.
Solubility of Aripiprazole in supercritical carbon dioxide: Experimental and modeling evaluations
Authors: Ansari Eslam , Honarvar Bizhan , Sajadian Seyed Ali , Aboosadi Zahra Arab , Azizi Mehdi
Published: May 2023

The solubility of compounds in supercritical carbon dioxide (SC-CO2) has found crucial significance in the fabrication of micro/nano-scaled drugs. In this research, the solubility of Aripiprazole was measured in SC-CO2 in various temperatures (308-338 K) and pressures (12-30 MPa). Moreover, the experimental solubility results were correlated with several semi-empirical models (Chrastil, Bartle et al., Kumar & Johnston, Menden-Santiago & Teja, Sodeifian et al., and Jouyban et al.) as well as the modified Wilson model. The molar fraction of the drug in SC-CO2 varied the range of 1.83 × 10-6 to 1.036 × 10-5. The solubility highly depended on operating pressure and temperature. The Chrastil (0.9936) and Sodeifian et al. (0.9923), and Jouyban et al. (0.9916) models showed the highest consistency with the obtained values. Furthermore, self-consistency tests were performed on the solubility of Aripiprazole in SC-CO2. The approximate total enthalpy (ΔHtotal), vaporization enthalpy (ΔHvap), and solubility enthalpy (ΔHsol) were also calculated.
Plant defensin gene PfPDF2 from Perilla frutescens confers high-level resistance to Alternaria brassicae and Botrytis cinerea in Brassica napus
Authors: Xu Huaxiang , Guo Xi , Bai Huiyang , Yu Jie , Shi Huimin , Lu Junxing , Zhu Bo , Zhang Tao
Published: May 2023

Background Plant defensins (PDF) are a group of small cysteine-rich peptides with broad-spectrum antimicrobial activity that play important roles in the response of plant to abiotic stresses.Results In this study, Perilla frutescens PDF (PfPDF) genes were identified and functionally characterized. A total of 6 PfPDF genes were successfully cloned. Characterization analysis revealed that all PfPDF genes consisted of 2 exons and 1 intron and encoded 73 ~ 88 amino acids, each of which contained 8 cysteine residues. Phylogenetic analyses indicated that all PfPDFs were members of the PDF type I family. The expression of PfPDF genes showed wide tissue specificity. PfPDF1, PfPDF2 and PfPDF4 were expressed in stems, leaves, flowers and seeds, and PfPDF3 was expressed in leaves and seeds, while PfPDF5 and PfPDF6 were only expressed in seeds. Subsequently, PfPDF2, which was highly expressed in seeds, was transformed into Brassica napus to obtain transgenic plants. The total yield of transgenic B. napus was comparable to that of wild-type. Moreover, an in vitro antifungal bioactivity test on leaves revealed that the resistance to Alternaria brassicae and Botrytis cinerea was enhanced significantly in PfPDF2-overexpressing B. napus compared to that of the wild type. Analysis of differentially expressed genes in wild-type and transgenic B. napus showed that photosynthesis, fatty acid biosynthesis and metabolism pathways were significantly activated.Conclusions Overall, this study identified and characterized PDF genes from P. frutescens for the first time and clarified that PfPDF2 could be applied to produce crops with higher resistance to pathogens, providing unique insights and new genetic resources for molecular breeding.