bluuebunny/crossref_metadata_2025 huggingface dataset:
Revumenib for patients with acute leukemia: a new tool for differentiation therapy
Authors: Salman Meira Yisraeli , Stein Eytan M.
Published: August 2024

Treatment of acute leukemia is gradually moving away from a “one-size-fits-all” approach, as scientific and clinical advances expand the arsenal of available targeted therapies. One of the recent additions are the menin inhibitors; oral, selective, small molecules that disrupt the interaction between the chromatin adapter menin, and an epigenetic regulator, the Lysine Methyltransferase 2A (KMT2A) complex. Two susceptible leukemia subtypes have been identified: 1) Acute Myeloid Leukemia (AML) with a mutation in Nucleophosmin 1 (NPM1), and 2) any acute leukemia, myeloid or lymphoid, with a translocation resulting in the rearrangement of KMT2A. These leukemias share a distinct genetic expression, maintained by the KMT2A-menin interaction. Together they account for approximately 40% of patients with AML, and 10% of patients with Acute Lymphoblastic Leukemia (ALL).
This review follows the journey of revumenib, as a representative of menin inhibitors, from bench to bedside. It will focus on the pathophysiology of leukemias sensitive to menin inhibition, delineation of how this understanding led to targeted drug development, and data from clinical trials. The important discovery of resistance mechanisms will also be explored, as well as future directions in using menin inhibitors for treating leukemia.
Superior survival with allogeneic hematopoietic stem cell transplantation versus chemotherapy for high-risk adult acute lymphoblastic leukemia in a PDT-ALL-2016 pediatric-inspired cohort
Authors: Chen Junjie , Cai Zihong , Huang Zicong , Lin Jieping , Wang Zhixiang , Ou Jiawang , Xu Xiuli , Tang Bingqing , Ding Chenhao , Li Jia , Lin Ren , Zhang Ting , Xuan Li , Liu Qifa , Zhou Hongsheng
Published: August 2024

Not available.
The component composition of the total flavonoid fractions from some Ericaceae family and their effect on the NO-stimulating activity of peritoneal macrophages
Authors: Reshetov Ya. E. , Ligacheva A. A. , Trofimova E. S. , Selivanova N. S. , Krivoshchekov S. V. , Basova E. V. , Sherstoboev E. Yu. , Avdeeva E. Yu. , Kaminsky I. P. , Danilets M. G. , Belousov M. V.
Published: August 2024

Introduction. Representatives of the Ericaceae family are quite common in Russia and are promising for the creation of new medicines of plant origin. At the same time, only 4 of them are official. The study of biologically active substances and pharmacological activity of Andromeda polifolia L., Chamaеdaphne calyculata (L.) Moench, Ledum palustre L., Empetrum nigrum L. with rich resource reserves is promising.

Aim. Comparative study of the composition of total flavonoid fractions from A. polifolia, C. calyculata, L. palustre, E. nigrum and study of their effect on the NO-stimulating activity of peritoneal macrophages

Materials and methods. The crushed aboveground part (leafy shoots) was previously depigmented with chloroform, treated with 70 % aqueous acetone, then acetone was removed. Flavonoids were extracted with ethyl acetate from the aqueous phase. The identification of flavonoids was carried out by HPLC (UltiMate 3000 chromatograph) according to the coincidence of retention times and spectral characteristics, the calculation of the content was carried out by simple normalization. The effect of the samples on nitric oxide production was studied on macrophages of C57BL/6 mice. Endotoxin control in the samples was carried out using a LAL test and cell incubation in the presence of polymyxin B.

Results and discussion. The composition of flavonoid fractions from A. polifolia, C. calyculata, L. palustre and E. nigrum has been studied. 8 phenolic compounds were found in C. calyculata shoots, including isoquercitrin, herbacetin, naringenin and naringin – for the first time for this species. 5 compounds were detected in A. polifolia shoots, including isoquercitrin and herbacetin, for the first time for this species. 5 and 4 compounds were identified in L. palustre and E. nigrum shoots, respectively, while quercetin glycosides are predominant in all samples: isoquercitrin, hyperoside and rutin. The fraction of C. calyculata flavonoids at doses of 1, 5, 10 mcg/ml inhibits the production of nitric oxide by macrophages by 30 %, and E. nigrum flavonoids at doses of 100 and 200 mcg/ml, on the contrary, enhance the production of nitrites by macrophages by 33 and 37 %, respectively.

Conclusion. A comparative study of the composition of total flavonoid fractions from A. polifolia, C. calyculata, L. palustre, and E. nigrum, which are capable of activating both M1 and M2 polarization of peritoneal macrophages in mice, has been conducted, which requires further in-depth study. The flavonoids C. calyculata and E. nigrum are promising for further study.
Livestock diseases in Northeastern Brazilian Amazon region: A survey of 448 tissues samples submitted for histopathological evaluation between 1997 and 2017
Authors: Pires Ana Paula de Castro , Oliveira Mariana Correia , Costa Samay Zillmann Rocha , Cordeiro Matheus Dias , Bomjardim Henrique dos Anjos , Oliveira Carlos Magno Chaves de , Barbosa José Diomedes , Brito Marilene de Farias
Published: August 2024

The amazon river The Amazon River basin is known for its great variety of vegetation and animals, as well as for the prominent cattle ranching. However, Amazonia hot and humid natural climate is a suitable environment for the development and spread of diseases, posing a challenge for the livestock sector. This study aimed to study livestock diseases in the northeastern Brazilian Amazon Region though a survey of tissue samples submitted to histopathological. A retrospective study was conducted in the archives of the Anatomical Pathology Sector of the Federal Rural University of Rio de Janeiro, Brazil, between 1997 and 2017. It was included tissue of bovine, bubaline, equine, ovine, and caprine collected in the Northeastern Brazilian Amazon Region and submitted to histopathological evaluation. Data on species, histologic description, and diagnosis were retrieved from the pathological reports, and ancillary techniques were applied to elucidate inconclusive cases. Between January 1997 and July 2017, 448 tissue samples were submitted for histopathological evaluation. Infectious diseases comprised 31.5% (141/448) of all diagnoses, followed by mineral imbalances (16.5%), neoplasia (10.7%), and poisonous plants and related conditions (8.9%). Histochemical, immunohistochemical and molecular techniques proved seem to be useful to help elucidate inconclusive cases.
Expansão rápida da maxila em pacientes adultos – Uma revisão integrada
Authors: Bomfim Manoella Carvalho , Vera Juan Miguel Antezana , Vera Saul Alfredo Antezana
Published: August 2024

A expansão rápida da maxila (ERM) em pacientes adultos é um tema crucial na ortodontia contemporânea, oferecendo novas perspectivas e soluções para casos desafiadores de discrepâncias esqueléticas e dentárias. Este estudo tem como objetivo examinar a eficácia da expansão rápida da maxila assistida por MARPE e mini- implantes, destacando os benefícios e as considerações clínicas envolvidas nesse procedimento inovador. A expansão rápida da maxila é uma técnica consagrada na ortodontia para corrigir problemas de mordida cruzada posterior e maxilares estreitos. Os estudos clínicos demonstram que a utilização de mini-implantes como ancoragem esquelética proporciona uma expansão mais controlada e estável da maxila, minimizando efeitos colaterais e melhorando a função respiratória e a saúde periodontal. Além de reduzir o tempo de tratamento e a colaboração interdisciplinar entre ortodontistas e cirurgiões-dentistas é indispensável para maximizar os efeitos.
Saberes docentes de professores de matemática: Análise do método Peer Instruction
Authors: Neves Inajara Salles Viana , Silva Mayara Maia Bruno Nepomuceno , Vasconcelos Lucas de , Faria Pauline Neiva
Published: August 2024

A utilização de metodologias ativas para o processo de ensino-aprendizagem, pode favorecer a relação aluno/aluno e professor/aluno, uma vez que estas baseiam-se em procedimentos que auxiliam na construção do conhecimento, já que elas possibilitam ao estudante poder desenvolver habilidades relacionadas a autonomia e protagonismo. Com o intuito de pesquisar sobre a formação do professor de matemática, este trabalho, que é recorte de uma investigação dentro da linha de pesquisa Formação de Professores que Ensinam Matemática do Mestrado Acadêmico em Educação Matemática (PPGEDMAT), da Universidade Federal de Ouro Preto (UFOP), teve como objetivo geral compreender que saberes docentes são mobilizados por meio do método Peer Instruction em aulas de Matemática. Para isso, a investigação pautou-se em uma abordagem qualitativa, na qual foi proposta a seguinte questão de investigação: Que saberes docentes são mobilizados por meio do método Peer Instruction em aulas de Matemática? Assim, o presente artigo apresenta uma breve descrição sobre o método Peer Instruction, uma metodologia de aprendizagem ativa e colaborativa, considerando suas potencialidades para o processo de ensino e de aprendizagem nas aulas de matemática. Como resultado da revisão da literatura, constatou-se que as metodologias ativas, com destaque ao método Peer Instruction, incentivam os alunos a pensarem de forma crítica, a questionar, a analisar e a construir um conhecimento sólido sobre a Educação Matemática.
O transtorno de ansiedade e as diferentes formas de tratamento: Uma revisão narrativa
Authors: Santana Raissa Siqueira , Ferreira Veridiane , Moraes Amanda de Carvalho Pereira
Published: August 2024

O transtorno de ansiedade generalizada (TAG) é caracterizado por preocupações excessivas e de difícil controle, que causam sofrimento significativo e prejudicam diversos aspectos da vida do indivíduo. A busca por estratégias eficazes de tratamento é crucial para aliviar os sintomas e melhorar a qualidade de vida dos pacientes. O objetivo do presente estudo é elucidar a fisiopatologia da ansiedade e identificar os diferentes tratamentos na TAG. A metodologia inclui uma revisão bibliográfica integrativa, utilizando bases de dados como PubMed Central®, SciELO e Biblioteca Virtual em Saúde. Foram selecionados artigos que abordem a TAG e suas terapias. A Terapia Cognitivo-Comportamental (TCC) destaca-se como a primeira escolha terapêutica, complementando o uso de fármacos e mudanças nos hábitos de vida. Os medicamentos da classe dos inibidores seletivos de recaptação de serotonina (ISRS) emergem como a opção principal devido à sua excelente eficácia e perfil de efeitos adversos mais brandos. Em suma, uma abordagem integrada que combina tratamento farmacológico, intervenções não farmacológicas e tratamentos fitoterápicos são cruciais para o manejo eficaz dos transtornos de ansiedade. Assim, essas estratégias multifacetadas visam enfrentar os desafios da ansiedade de forma abrangente, promovendo uma saúde mental mais robusta e resiliente.
O impacto da avaliação geriátrica direcionada de 10 minutos (TaGa-10) no prognóstico do paciente idoso
Authors: Espindola Mylena Delamare , Chaves Matheus Gonçalves
Published: August 2024

Na última década observou-se um aumento significativo da expectativa de vida no Brasil para a média de 75,5 anos mesmo após a pandemia do COVID-19 entre os anos de 2020-2022, e concomitante a este crescimento houve também um aumento no número das doenças crônico-degenerativas. A despeito das melhorias realizadas no âmbito da medicina, desde o diagnóstico até o tratamento destas doenças, ficou evidente a necessidade de um instrumento multidimensional para identificar de maneira mais breve e eficaz quais são os idosos considerados frágeis com maior propensão para evoluir com desfechos desfavoráveis e o não benefício de medidas invasivas. Este artigo é um estudo do tipo descritivo e reflexivo estruturado a partir da análise de artigos de bases de dados diferentes publicados entre os anos de 2019-2023 com o objetivo de discorrer sobre o impacto da avaliação geriátrica direcionada de 10 minutos (TaGa-10) na predição do prognóstico do paciente idoso.
Bronquiolite obliterante pós-infecciosa em crianças: Um destaque para a infecção pelo adenovírus
Authors: Carvalhais Bárbara Salvador , Fernandes Maryah Goulart Magalhães , Ferreira Ana Laura Costa , Almeida Jordana Fernandes , Costa Gabriel Starling
Published: August 2024

Introdução: A Bronquiolite Obliterante pós infecciosa (BOPI) é um distúrbio pulmonar crônico e irreversível que acomete as vias aéreas inferiores. Representa uma afecção rara, que é mais comum em crianças, após um episódio severo de infecção viral, sobretudo pelo Adenovirus. Objetivo: Reunir as principais atualizações acerca da BOPI, em seus diversos aspectos, principalmente decorrente da infecção pelo AV. Materiais e Métodos: Trata-se de uma revisão integrativa de literatura acerca das características clinicas gerais sobre das varizes esofagianas. Utilizou-se a estratégia PICO para a elaboração da pergunta norteadora. Ademais, realizou-se o cruzamento dos descritores “Bronquiolite Obliterante”, “Adenovírus”, “Pediatria”; “Criança”, nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Eletronic Library Online (SCIELO), Ebscohost, Google Scholar e Biblioteca Virtual de Saúde (BVS). Resultados e Discussão: É essencial atentar-se aos fatores de risco e ao perfil do paciente, que geralmente é um menino, com menos de um ano de idade. A hipoxemia e a necessidade de ventilação mecânica são importantes fatores de risco. Os sintomas que falam a favor da BOPI envolvem taquipneia, tosse, sibilos, intolerância ao exercício e hipoxemia persistente por pelo menos 6 semanas após um quadro de bronquiolite severa ou de pneumonia com insuficiência respiratória. A avaliação dos critérios diagnósticos representa uma ferramenta importante para auxílio da elucidação do caso. Conclusão: Ainda faltam conhecimentos específicos que facilitem o reconhecimento precoce, a prevenção e o tratamento da doença, especialmente após infecções pelo adenovírus.
DEVELOPMENT A DAILY NUTRITIONAL ADEQUACY BALANCE IDENTIFICATION SYSTEM AS AN EFFORT TO PREVENT MALNUTRITION
Authors: Izzah Abidatul , Swanjaya Daniel , Eliyen Kunti
Published: August 2024

Malnutrition is a deficiency, excess or imbalance in a person's energy and nutritional intake. Malnutrition can occur when a person has too much or too little food and important nutrients in their body. The Ministry of Health, Indonesia, has campaigned for food consumption that complies with balanced nutrition guidelines under the slogan "Isi Piringku". However, the guidelines regarding this matter are still not properly understood by the public. Even if implemented, the nutritional levels contained in one portion of food consumed cannot yet be measured. Thus,  to identify the fulfillment of balanced nutritional, a device is needed to easily detect how much calories is consumed. Therefore, this research aims to develop a system which can identify whether the portion of food consumed meets balanced nutrition or not. It is developed in Django framework, Python programming language, and MySQL database. It has been evaluated using black box testing, white box testing, and system usability scales. The result shows that all system requirements have been run well. Meanwhile, system usability testing result shows that the identification system has been tested with a score of 82 and categorized in Excellent.
BRAIN TUMOR CLASSIFICATION USING INCEPTIONRESNET-V2 AND TRANSFER LEARNING APPROACH
Authors: Kurniawan Vallent Austin Theasar , Niswary Elan Cahya , S.k.aditya Christian , Chandranegara Didih Rizki
Published: August 2024

Brain, a highly intricate organ within the central nervous system, plays a fundamental role in information processing, cognition, motor control, and consciousness. Brain tumors pose severe threats to brain function and overall human well-being. Timely detection of these tumors is imperative for life-saving interventions. A dataset comprising four categories: no tumors, meningioma tumors, glioma tumors, and pituitary tumors was regarded in this research. The employed of the InceptionResNet-V2 architecture combined with Transfer Learning and data augmentation proposed to obtain optimal results on brain tumor classification types. Transfer learning act as fine tuning, enabling the model to acquire fundamental low-level image features from a comprehensive dataset. It then leverages higher-level features to become more tailored to the specific training data. This method is employed to improve the model's adaptability to the training data. The InceptionResNet-V2 architecture utilized in the evaluation using test data, in Scenario 1, achieved 94.18% accuracy. Scenario 2, which combined augmentation with InceptionResNetV2, showed an improvement in accuracy to 95.10%. Furthermore, in Scenario 3, the combination of InceptionResNetV2 with Transfer Learning and augmentation resulted in an impressive accuracy of 96.63%, demonstrating its effectiveness in brain tumor classification. Transfer learning aligns the model by acquiring low-level image features and utilizing higher-level features to improve adaptability to the training data.
IMPLEMENTATION OF FISHER-YATES SHUFFLE ALGORITHM IN ANDROID-BASED JAVANESE BATIK CULTURE EDUCATION GAME
Authors: Rahman Ben , Naufal Shofy Mochamad , Andryana Septi
Published: August 2024

Batik, as one of Indonesia's precious cultural heritages, has a variety of motifs in the art of batik in this country. The preservation of batik is important and the success of educational games in supporting this goal has been proven. Understanding the complex meaning and philosophy of batik is difficult given the variety of motifs. Therefore, this research creates an Android game that incorporates elements of batik culture to introduce the meaning and philosophy of Indonesian batik to the next generation. Android technology makes learning more flexible, allowing unrestricted access to information. By following the Game Development Life Cycle (GDLC) method and integrating the Fisher-Yates Shuffle algorithm and Finite State Machine (FSM), this game takes players on an adventure against Non-Playable Character (NPC) characters using the FSM model. The Fisher-Yates Shuffle algorithm is used to randomize 10 questions, making each game session unique. The algorithm test results showed an average question execution time of about 35.6 microseconds, indicating stable performance despite variations in each trial. The alpha test results showed an average score of 87%, covering aspects of information readability, responsiveness, player motivation, combat experience, educational benefits, as well as satisfaction, and game design that showed good performance. Thus, this research succeeded in creating an educational game that is entertaining and educational, as well as helping to maintain and introduce batik cultural heritage to the next generation.
Analisis Penerapan Desain Biofilik Untuk Meningkatkan Produktivitas Ruang Bekerja Pada Industri Kreatif
Authors: Hanafi Muhammad Hasan , Maharani Rizka Tiara
Published: August 2024

Creative industries have great potential and will continue to grow with the advancement of time. As a result, communities in the creative industries will continue to be formed, creating a space for collaboration that is contained in the creative workspace. The activities carried out in the workspace often require high productivity and creativity. If this is done continuously, it can lead to emotional and physical fatigue that can reduce work productivity. The solution to address this is to improve the comfort of working in the creative workspace environment with a biophilic approach in order to create a comfortable workspace that can improve productivity and creativity while working. This study aims to conduct a study of literature and journals that discuss biophilic design in the workplace that has an impact on the performance of creative industry actors. The research method chosen for this study is short communication by filtering journals and taking keywords "Biophilic", "Workspace", "Productive", and "Creative" in journal databases such as ResearchGate, ScienceDirect, Google Scholar, and Green Plants for Green Building. This study is expected to provide recommendations for researchers and architectural designers in designing workspaces. The results of this study are expected to produce workspace design criteria that can provide comfort and improve productivity and creativity of its users in the creative industry environment
Pengaplikasian Konsep Mindful Space Terhadap Interior Ruang Kelas Taman Kanak-kanan
Authors: Gani Anastasia Cinthya , Utama Missheal , Effendi Andrey Caesar
Published: August 2024

Early childhood is a golden period where support is needed from various parties, one of which is school. But in reality, there are still many educational institutions that have not been able to meet all the needs of children, one of which is in terms of facilities, such as interiors. This discussion highlights the classrooms of Shining Stars Preschool & Kindergarten in South Tangerang as a case study. Through the interior design process, the concept formed is Mindful Space. The main focus of this concept is to create a space where inspiration, creativity and comfort can come together. The design adopts a modern interior style with the use of soft colors that create a comfortable yet fun atmosphere for children. This research uses a qualitative method with an analysis and synthesis approach. The collection of ideas is done through sources such as the internet, books, journals, and direct observation in the field. Thus, this abstract provides an overview of the importance of appropriate and supportive interior design for early childhood in an educational context, with this research as an example of its implementation at Shining Stars Preschool & Kindergarten.
Cover dan Daftar Isi
Authors: Putri Salsabila Shofia Paramitha Yonky
Published: August 2024

Cover dan Daftar Isi
Penglibatan Golongan Belia dan Cadangan dalam Mengurangkan Kegiatan Mat Rempit
Authors: Muhd Khairul Najmi bin Nasir  , Athirah Azhar
Published: August 2024

One of the reasons of societal issues among young people nowadays might be attributed to ‘Mat Rempit's’ or ‘merempit's’ actions. The three objectives of the study are to determine the causes teens involved in Mat Rempit activities, to identify the effects to the teens, and to suggest steps may be taken to prevent Mat Rempit activities among teenagers. This study employs a qualitative methodology by interviewing five respondents. The sample of respondents was chosen randomly. Thematic analysis was used to analyse the data. From the findings peer pressure, social media, money, and self-interest in the automotive industry are the main reasons why teens involved in Mat Rempit activities. These have caused accidents, caught up in more serious societal issues, and excessive financial squandering. It is suggested that to increase the age limits for licence applications, adding more public circuits, and police operations on weeknights. In conclusion, it is hope that the study's findings on the world of motoring would help to inform the public and raise youngsters' knowledge of the risks associated with Mat Rempit activities.
PENGARUH KESELAMATAN KESEHATAN KERJA DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN DI PERUMDAM TIRTA KENCANA JOMBANG
Authors: Revinda Della Candra , Anah Lik
Published: August 2024

Penelitian ini bertujuan untuk mengetahui pengaruh keselamatan kesehatan kerja dan lingkungan kerja terhadap kinerja. Objek pada penelitian ini adalah karyawan Perumdam Tirta Kencana Jombang. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Populasi dalam penelitian ini berjumlah 83 karyawan dengan teknik pengambilan sampel menggunakan random sampling dengan rumus slovin dan diperoleh sampel sejumlah 69 responden. Hasil penelitian ini menyatakan bahwa: (1) Keselamatan Kesehatan Kerja berpengaruh positif dan signifikan terhadap Kinerja Karyawan Di Perumdam Tirta Kencana Jombang. (2) Lingkungan Kerja berpengaruh positif dan signifikan terhadap Kinerja Karyawan Di Perumdam Tirta Kencana Jombang. (3) Keselamatan Kesehatan Kerja Dan Lingkungan Kerja secara simultan berpengaruh positif dan signifikan terhadap Kinerja Karyawan Di Perumdam Tirta Kencana Jombang
PENGARUH LINGKUNGAN KERJA FISIK DAN KOMITMEN ORGANISASI TERHADAP PRODUKTIVITAS KERJA KARYAWAN PADA UD FAVOURITE JOMBANG
Authors: Novelya Aufin Ayunda , Anah Lik
Published: August 2024

Tujuan dari penelitian ini untuk mengetahui pengaruh lingkungan kerja fisik dan komitmen organisasi terhadap produktivitas kerja karyawan pada UD Favourite Jombang. Penelitian ini menggunakan metode kuantitatif dengan jenis penelitian yang bersifat kausal. Populasi penelitian ini yaitu seluruh karyawan UD Favourite Jombang berjumlah 120 karyawan, kemudian diambil sampel berjumlah 80 karyawan bagian produksi dengan teknik sampling purposive. Hasil penelitian memperlihatkan bahwa: 1) Lingkungan kerja fisik berpengaruh positif dan signifikan terhadap produktivitas kerja karyawan pada UD Favourite Jombang, 2) Komitmen organisasi mempunyai pengaruh positif dan signifikan terhadap produktivitas kerja karyawan pada UD Favourite Jombang, 3) Lingkungan kerja fisik dan komitmen organisasi secara bersama-sama berpengaruh positif dan signifikan terhadap produktivitas kerja karyawan pada UD Favourite Jombang
Pengaruh Lingkungan Kerja Dan Disiplin Kerja Terhadap Kinerja Karyawan Pada Divisi Produksi Pt. Gemilang Inti Sukses Jombang
Authors: Anggriani Inggi , Laili C
Published: August 2024

Penelitian ini bertujuan untuk mengetahui pengaruh lingkungan kerja dan disiplin kerja terhadap kinerja karyawa pada divisi produksi PT. Gemilang Inti Sukses Jombang. Metode yang digunakan pada penelitian ini adalah metode penelitian kuantitatif dengan alat analisis regresi linier berganda. Jumlah sampel dalam penelitian ini sebanyak 60 responden, dengan menggunakan teknik slovin. Hasil penelitian menunjukkan bahwa: (1) Lingkungan kerja mempunyai pengaruh tidak signifikan terhadap kinerja karyawan pada divisi produksi PT. Gemilang Inti Sukses Jombang, (2) Disiplin kerja mempunyai pengaruh positif terhadap kinerja karyawan pada divisi produksi PT. Gemilang Inti Sukses Jombang, (3) Lingkungan kerja dan disiplin kerja secara simultan berpengaruh signifikan terhadap kinerja karyawan pada divisi produksi PT. Gemilang Inti Sukses Jombang.
STRATEGI PEMASARAN DALAM UPAYA MENINGKATKAN KEUNGGULAN BERSAING JASA KONTRUKSI PADA PT. JATRA SEJAHTERA MOJOAGUNG JOMBANG
Authors: Mahfudiyanto  , Saadah Alfiatus
Published: August 2024

Penelitan ini bertujuan untuk mengetahui bagaimana strategi pemasaran yang dilakukan oleh PT. Jahtra Sejahtera Mojoagung Jombang dalam rangka untuk meningkatkan keunggulan bersaing jasa kontroksi, penelitian ini menggunakan metode kualitatif, Hasil dalam penelitian ini penunjukkan bahwa upaya perusahaan dalam meningkatkan keunggulan bersaing yaitu dengan meningkatkan kualias kerja, dengan cara meningkatkan keterampilan dan pengetahuan karyawan melalui pelatihan dan pengembangan dapat membantu perusahaan menghadapi tantangan yang kompleks, mengembangkan metode kerja, menggunakan metode manajemen proyek yang baik dapat membantu perusahaan menyelesaikan proyek tepat waktu dan dalam anggaran, yang pada gilirannya dapat meningkatkan reputasi dan kepercayaan pelanggan, melengkapi dokumen-dokumen yang dibutuhkan untuk pekerjaan kontrak agar sesuai standar nasional, misalnya : sertifikat pekerja, sertifikat alat, sertifikat iso. Keunggulam kompetitif yang dimiliki perusahaan sangat baik pengalaman senior dan kemampuan untuk memproduksi alat sesuai yang diinginkan adalah aset berharga. Kemampuan untuk memprosuksi alat sesuai metode yang diinginkan menunjukkan fleksibilitas dan adaptabilitas perusahaan. Perusahaan harus memanfaatkan keunggulan ini untuk membedakan diri dari pesaing dan menarik lebih banyak pelanggan.
ANALISIS PENGARUH LABEL HALAL DAN FOOD DRUG ADMINISTRATION TERHADAP MINAT BELI SANTRIWATI
Authors: Sobaroh Lutfia , Sopingi Imam , Santoso Rohmad Prio
Published: August 2024

Penelitian ini bertujuan untuk menginvestigasi pengaruh label halal dan sertifikasi dari Food and Drug Administration (FDA) pada produk kosmetik terhadap minat beli santriwati. Label halal menjadi indikator penting bagi konsumen Muslim dalam memastikan produk yang konsumsi sesuai dengan hukum syariah, sementara sertifikasi FDA memberikan jaminan bahwa produk telah memenuhi standar keamanan dan kesehatan. Santriwati sebagai konsumen memiliki kebutuhan dan preferensi khusus dalam memilih produk kosmetik yang sesuai dengan keyakinan dan nilai-nilai agamanya. Label halal dan sertifikasi FDA dianggap sebagai faktor penting yang memengaruhi keputusan pembelian. Metode penelitian ini menggunakan pendekatan Kuantitatif dengan teknik Purposive sampling dengan jumlah sampel 155 responden. Data yang terkumpul dianalisis menggunakan regresi linear berganda. Hasil penelitian menunjukkan secara parsial maupun simultan label halal dan food and drug administration mempengaruhi terhadap minat beli santriwati. Hal ini menunjukkan pentingnya produsen kosmetik untuk mempertimbangkan label halal dan sertifikasi FDA sebagai strategi pemasaran yang efektif dalam menarik minat beli dari konsumen santriwati.
The Relationship Between Knowledge, Motivation, and Supervision Towards Documentation Among Nurses at Private Hospital in Indonesia
Authors: Suryani Lilis , Masmulyadi Masmulyadi , Perdani Agni Laili
Published: August 2024

Aims: Nursing care documentation is an essential part and integrated within the nursing process. The previous study described incomplete nursing records, reflecting the quality of nursing care and implementation of patient safety. This study aim is to explore the relationship between knowledge, motivation and supervision toward nursing documentation.
Method: A descriptive-quantitative research method with a cross-sectional approach was implemented. A total of 64 respondents are agreed to participate with the convenience sampling method in one month in December 2020. Data collection used a self-report questionnaire and observational form with the accepted value of validity and reliability. Data analysis by bivariate with Chi-square and multivariate with Logistic.
Results: Nurses showed good knowledge (n=57; 89.1%) and motivation (n=35;54.7 %) whilst poor supervision (n=31;48.4) and documentation (n= 40; 62.5%) Supervision is statistically significant had relationship with nursing documentation OR 3.333 (1.151-9.650) p-value < 0.05 and strong associated with nursing documentation β = 3.517 (1.182-10.469).
Conclusion: Increasing knowledge, motivation, supervision is needed to protect both nurses and patients. Supervision activities are the tools to evaluate the nursing process and ensure continuity of care.
Risk Factors of Metabolic Syndrome Among Nurses Hospital Banten, Indonesia
Authors: Yulistriani Anisa , Rayasari Fitrian , Munaya Munaya , Jumaiyah Wati , Abriyanti Rika Mustika
Published: August 2024

Aims: This study was to determine the prevalence of metabolic syndrome and its associated factors among nurses in Banten.
Methods: The cross-sectional design of this particular type of quantitative correlation study. A total of 102 respondents were comprised of samples selected using random sampling. Variabel aktivitas fisik diidentifikasi menggunakan APARQ (Adolescent Physical Activity Recall Questionnaire) dan Stres diidentifikasi menggunakan DASS 21. Metabolic indicators include hypertension, Obesity, cholesterol, and diabetes. Data analysis used logistic regression.  
Result:  The prevalence of metabolic syndrome among nurses was 16.7%. Older age (p=0.006), smoking (p=0.008), and stress (p=0.000) were significantly associated with metabolic syndrome. While gender and exercise were not significantly associated with metabolic syndrome. 
Conclusion: smoking and stress were the major modifiable risk factors of metabolic syndrome among nurses. Campaigns and prevention of healthy behavior are crucial even among healthcare professionals.
“Until then, I thought it was a cancer that would kill me. Now I wondered whether resistant infection might be a more imminent threat.” Laila, 32, with advanced bowel cancer, speaking in the 'mini-film' False Peak on her experience of a drug resistant sepsis that delayed her cancer therapy.
Authors: McCall Becky , Shallcross Laura , Wilson Michael
Published: August 2024

Here I present the first in a series of 3-5 minute, ‘mini-films’ (digital stories) co-created with people who have experienced drug resistant infections. Called StoryBug, the project, brings true, real-life personal stories of people who have experienced antibiotic resistant infections to the public. Unlike more conventional films or videos that use big budget production crews, StoryBug helps the people who have experienced antibiotic resistant infections to create the video themselves – they are placed front and centre, by scripting in the first-person and using mobile phone imagery. Here, we use the Common Language Digital Storytelling (DST) process. The digital stories can serve the purposes of education, research, and advocacy (knowledge translation), and a form of therapy (informal). These stories could form a cornerstone of a multimedia public health campaign to support policy and National Action Plans (NAP) while encompassing a societal perspective in stimulating a multi-stakeholder dialogue. False Peak is featured in the UK's 2024-2029 NAP. The complete series of five stories is based on patient experience but could apply equally to stories from farmers, vets, pharmaceutical companies, or other stakeholders involved in AMR in the environment - anyone who has an experience related to AMR or antibiotic use that they are willing to share. Story 1: False Peak This is the story of a young woman, who developed an antibiotic resistant infection while undergoing chemotherapy for advanced bowel cancer.
Characterization of genes and proteins involved in the absorption of long-chain fatty acids in the gastrointestinal tract of cattle
Authors: Hentz Fernanda , Batistel Fernanda
Published: August 2024

Introduction

Dietary fatty acids play a pivotal role in energy metabolism and various physical functions. However, the molecular mechanisms underlying the absorption of long-chain fatty acids (LCFA) in ruminant animals remain poorly understood. To address this gap, we investigated the occurrence and distribution of genes and proteins previously characterized in nonruminant models within the gastrointestinal tract of cattle.

Methods

Tissue samples from the rumen, descending duodenum, proximal jejunum, medial jejunum, distal jejunum, and distal ileum were collected at slaughter from eight Holstein steers. RT‒PCR and capillary electrophoretic-based chemiluminescence were used to determine the mRNA and protein levels of genes and proteins involved in the uptake, activation, intracellular trafficking, re-esterification, and lipoprotein assembly of LCFA.

Results and discussion

Measurable mRNA levels were found for 38 genes involved in the intestinal absorption of LCFA in all examined sections of the bovine gastrointestinal tract. The mRNA abundances of all genes were greater in the intestinal sections than in the rumen sections (p < 0.05). At the protein level, the expression of nine key transporters and enzymes, namely, CD36, SLC27A4, ACSL1, FABP1, FABP2, DGAT1, MTP, Apo-AI, and ACAT2, was detected in most of the intestinal sections. The distribution profile of these proteins in the small intestine suggested a prominent role for protein-mediated absorption of LCFA in the proximal and distal intestine in cattle. The low expression levels of most proteins in the rumen suggest little absorption of LCFA at this location in cattle. Overall, the findings from this study support the presence, in cattle, of genes and proteins involved in the intestinal absorption of LCFA described in models of nonruminants. Identifying the proteins involved in the absorption of LCFA in the small intestine is the first step in understanding how the expression of these proteins influences the capacity of the small intestine to absorb fatty acids in cattle.
Transcriptional profiling identifies IL-33-expressing intestinal stromal cells as a signaling hub poised to interact with enteric neurons
Authors: Topczewska Patrycja M. , Savvopoulou Anna , Cosovanu Catalina , Klose Christoph S. N.
Published: August 2024

Recent advancements in mucosal immunology have unveiled a complex network of intercellular connections within diverse tissues, shedding light on the unique properties of different cell types. Central to this intricate network is the cytokine IL-33, which has gained significant attention for its critical role in various diseases, from allergy to cancer, triggering type 2 immune responses, among others. Recent research has challenged the prior assumptions attributing IL-33 expression to epithelial cells, highlighting stromal cells as the predominant source in adipose tissue and the lungs. However, in the complex landscape of the intestine, where IL-33 plays a crucial role in mediating immune surveillance and tolerance and is implicated in many gut-related disorders, its primary source, regulation, and main characteristics need more exploration. This study identifies stromal cells as the primary IL-33-expressing cell type in the small intestine. By investigating their transcriptome and intrinsic signaling pathways, we have uncovered a possible role of IL-33+ stromal cells in maintaining the stem cell niche and their potential crosstalk with neurons relevant to the regulation of axonogenesis. Importantly, our experiments have demonstrated that vasoactive intestinal peptide stimulation of a primary intestinal stromal cell culture significantly amplifies IL-33 expression on mRNA and protein level. Therefore, our study represents a significant leap forward in understanding the plethora of interactions IL-33+ intestinal stromal cells maintain in the intestine, paving the way for future investigations into stromal-neuro crosstalk in the gut. These findings hold great promise for developing targeted therapeutic strategies aimed at harnessing the potential of IL-33 across a spectrum of diseases.
Exploring the nexus between MYH9 and tumors: novel insights and new therapeutic opportunities
Authors: Gou Zixuan , Zhang Difei , Cao Hongliang , Li Yao , Li Yunkuo , Zhao Zijian , Wang Ye , Wang Yishu , Zhou Honglan
Published: August 2024

The myosin heavy chain 9 (MYH9) gene, located on human chromosome 22, encodes non-muscle myosin heavy chain IIA (NM IIA). This protein is essential to various cellular events, such as generating intracellular chemomechanical force and facilitating the movement of the actin cytoskeleton. Mutations associated with thrombocytopenia in autosomal dominant diseases first highlighted the significance of the MYH9 gene. In recent years, numerous studies have demonstrated the pivotal roles of MYH9 in various cancers. However, its effects on cancer are intricate and not fully comprehended. Furthermore, the elevated expression of MYH9 in certain malignancies suggests its potential as a target for tumor therapy. Nonetheless, there is a paucity of literature summarizing MYH9’s role in tumors and the therapeutic strategies centered on it, necessitating a systematic analysis. This paper comprehensively reviews and analyzes the pertinent literature in this domain, elucidating the fundamental structural characteristics, biological functions, and the nexus between MYH9 and tumors. The mechanisms through which MYH9 contributes to tumor development and its multifaceted roles in the tumorigenic process are also explored. Additionally, we discuss the relationship between MYH9-related diseases (MYH9-RD) and tumors and also summarize tumor therapeutic approaches targeting MYH9. The potential clinical applications of studying the MYH9 gene include improving early diagnosis, clinical staging, and prognosis of tumors. This paper is anticipated to provide novel insights for tumor therapy.
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells
Authors: Samaržija Ivana , Lukiyanchuk Vasyl , Lončarić Marija , Rac-Justament Anja , Stojanović Nikolina , Gorodetska Ielizaveta , Kahya Uğur , Humphries Jonathan D. , Fatima Mahak , Humphries Martin J. , Fröbe Ana , Dubrovska Anna , Ambriović-Ristov Andreja
Published: August 2024

Radiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling. To define these mechanisms, we employed a DU145 PC model to conduct a comparative mass spectrometry-based proteomic analysis of the purified integrin nexus, i.e., the cell-matrix junction where integrins bridge assembled extracellular matrix (matrisome components) to adhesion signaling complexes (adhesome components). When parental and radioresistant cells were compared, the expression of integrins was not changed, but cell radioresistance was associated with extensive matrix remodeling and changes in the complement of adhesion signaling proteins. Out of 72 proteins differentially expressed in the parental and radioresistant cells, four proteins were selected for functional validation based on their correlation with biochemical recurrence-free survival. Perlecan/heparan sulfate proteoglycan 2 (HSPG2) and lysyl-like oxidase-like 2 (LOXL2) were upregulated, while sushi repeat-containing protein X-linked (SRPX) and laminin subunit beta 3 (LAMB3) were downregulated in radioresistant DU145 cells. Knockdown of perlecan/HSPG2 sensitized radioresistant DU145 RR cells to irradiation while the sensitivity of DU145 parental cells did not change, indicating a potential role for perlecan/HSPG2 and its associated proteins in suppressing tumor radioresistance. Validation in androgen-sensitive parental and radioresistant LNCaP cells further supported perlecan/HSPG2 as a regulator of cell radiosensitivity. These findings extend our understanding of the interplay between extracellular matrix remodeling and PC radioresistance and signpost perlecan/HSPG2 as a potential therapeutic target and biomarker for PC.
Rational design of deep eutectic solvents for the stabilization of dehydrogenases: an artificial neural network prediction approach
Authors: Radović Mia , Jurinjak Tušek Ana , Reiter Tamara , Kroutil Wolfgang , Cvjetko Bubalo Marina , Radojčić Redovniković Ivana
Published: August 2024

Stabilized enzymes are crucial for the industrial application of biocatalysis due to their enhanced operational stability, which leads to prolonged enzyme activity, cost-efficiency and consequently scalability of biocatalytic processes. Over the past decade, numerous studies have demonstrated that deep eutectic solvents (DES) are excellent enzyme stabilizers. However, the search for an optimal DES has primarily relied on trial-and-error methods, lacking systematic exploration of DES structure-activity relationships. Therefore, this study aims to rationally design DES to stabilize various dehydrogenases through extensive experimental screening, followed by the development of a straightforward and reliable mathematical model to predict the efficacy of DES in enzyme stabilization. A total of 28 DES were tested for their ability to stabilize three dehydrogenases at 30°C: (S)-alcohol dehydrogenase from Rhodococcus ruber (ADH-A), (R)-alcohol dehydrogenase from Lactobacillus kefir (Lk-ADH) and glucose dehydrogenase from Bacillus megaterium (GDH). The residual activity of these enzymes in the presence of DES was quantified using first-order kinetic models. The screening revealed that DES based on polyols serve as promising stabilizing environments for the three tested dehydrogenases, particularly for the enzymes Lk-ADH and GDH, which are intrinsically unstable in aqueous environments. In glycerol-based DES, increases in enzyme half-life of up to 175-fold for Lk-ADH and 60-fold for GDH were observed compared to reference buffers. Furthermore, to establish the relationship between the enzyme inactivation rate constants and DES descriptors generated by the Conductor-like Screening Model for Real Solvents, artificial neural network models were developed. The models for ADH-A and GDH showed high efficiency and reliability (R2 > 0.75) for in silico screening of the enzyme inactivation rate constants based on DES descriptors. In conclusion, these results highlight the significant potential of the integrated experimental and in silico approach for the rational design of DES tailored to stabilize enzymes.
Late sporogonic stages of Plasmodium parasites are susceptible to the melanization response in Anopheles gambiae mosquitoes
Authors: Zeineddine Suheir , Jaber Sana , Saab Sally A. , Nakhleh Johnny , Dimopoulos George , Osta Mike A.
Published: August 2024

The malaria-causing parasites have to complete a complex infection cycle in the mosquito vector that also involves attack by the insect’s innate immune system, especially at the early stages of midgut infection. However, Anopheles immunity to the late Plasmodium sporogonic stages, such as oocysts, has received little attention as they are considered to be concealed from immune factors due to their location under the midgut basal lamina and for harboring an elaborate cell wall comprising an external layer derived from the basal lamina that confers self-properties to an otherwise foreign structure. Here, we investigated whether Plasmodium berghei oocysts and sporozoites are susceptible to melanization-based immunity in Anopheles gambiae. Silencing of the negative regulator of melanization response, CLIPA14, increased melanization prevalence without significantly increasing the numbers of melanized oocysts, while co-silencing CLIPA14 with CLIPA2, a second negative regulator of melanization, resulted in a significant increase in melanized oocysts and melanization prevalence. Only late-stage oocysts were found to be melanized, suggesting that oocyst rupture was a prerequisite for melanization-based immune attack, presumably due to the loss of the immune-evasive features of their wall. We also found melanized sporozoites inside oocysts and in the hemocoel, suggesting that sporozoites at different maturation stages are susceptible to melanization. Silencing the melanization promoting factors TEP1 and CLIPA28 rescued oocyst melanization in CLIPA2/CLIPA14 co-silenced mosquitoes. Interestingly, silencing of CTL4, that protects early stage ookinetes from melanization, had no effect on oocysts and sporozoites, indicating differential regulation of immunity to early and late sporogonic stages. Similar to previous studies addressing ookinete stage melanization, the melanization of Plasmodium falciparum oocysts was significantly lower than that observed for P. berghei. In summary, our results provide conclusive evidence that late sporogonic malaria parasite stages are susceptible to melanization, and we reveal distinct regulatory mechanisms for ookinete and oocyst melanization.
Dietary interventions in the management of atrial fibrillation
Authors: Nabil Muhammad Ahad , Rychlik Leanne , Nicholson Audrey , Cheung Peter , Olsovsky Gregory D. , Molden Jaime , Tripuraneni Ajay , Hajivandi Shayan-Salehi , Banchs Javier E.
Published: August 2024

Atrial fibrillation (AF) represents the most common cardiac arrhythmia with significant morbidity and mortality implications. It is a common cause of hospital admissions, significantly impacts quality of life, increases morbidity and decreases life expectancy. Despite advancements in treatment options, prevalence of AF remains exceptionally high. AF is a challenging disease to manage, not just clinically but also financially. Evidence suggests lifestyle modification, including dietary changes, plays a significant role in the treatment of AF. This review aims to analyze the existing literature on the effects of dietary modifications on the incidence, progression, and outcomes of atrial fibrillation. It examines various dietary components, including alcohol, caffeine, omega-3 polyunsaturated fatty acids and minerals, and their impact on AF incidence, progression, and outcomes. The evidence surrounding the effects of dietary patterns, such as the Mediterranean and low carbohydrate diets, on AF is also evaluated. Overall, this review underscores the importance of dietary interventions as part of a comprehensive approach to AF management and highlights the need for further research in this emerging field.