bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial Transcriptomic Analysis Using R-Based Computational Machine Learning Reveals the Genetic Profile of Yang or Yin Deficiency Syndrome in Chinese Medicine Theory
Authors: Zhang Cheng , Tam Chi wing , Tang Guoyi , Chen Yuanyuan , Wang Ning , Feng Yibin
Published: March 2022

Objectives. Yang and Yin are two main concepts responsible for harmonious balance reflecting health conditions based on Chinese medicine theory. Of note, deficiency of either Yang or Yin is associated with disease susceptibility. In this study, we aim to clarify the molecular feature of Yang and Yin deficiency by reanalyzing a transcriptomic data set retrieved from the GEO database using R-based machine learning analyses, which lays a foundation for medical diagnosis, prevention, and treatment of unbalanced Yang or Yin. Methods. Besides conventional methods for target mining, we took the advantage of spatial transcriptomic analysis using R-based machine learning approaches to elucidate molecular profiles of Yin and Yang deficiency by reanalyzing an RNA-Seq data set (GSE87474) in the GEO focusing on peripheral blood mononuclear cells (PBMCs). The add-on functions in R including GEOquery, DESeq2, WGCNA (target identification with a scale-free topological assumption), Scatterplot3d, Tidyverse, and UpsetR were used. For information in the selected GEO data set, PBMCs representing 20,740 expressed genes were collected from subjects with Yang or Yin deficiency (n = 12 each), based on Chinese medicine-related diagnostic criteria. Results. The symptomatic gene targets for Yang deficiency (KAT2B, NFKB2, CREBBP, GTF2H3) or Yin deficiency (JUNB, JUND, NGLY1, TNF, RAF1, PPP1R15A) were potentially discovered. CREBBP was identified as a shared key contributive gene regulating either the Yang or Yin deficiency group. The intrinsic molecular characteristics of these specific genes could link with clinical observations of Yang/Yin deficiency, in which Yang deficiency is associated with immune dysfunction tendency and energy deregulation, while Yin deficiency mainly contains oxidative stress, dysfunction of the immune system, and abnormal lipid/protein metabolism. Conclusion. Our study provides representative gene targets and modules for supporting clinical traits of Yang or Yin deficiency in Chinese medicine theory, which is beneficial for promoting the modernization of Chinese medicine theory. Besides, R-based machine learning approaches adopted in this study might be further applied for investigating the underlying genetic polymorphisms related to Chinese medicine theory.
The Impact of Intracoronary Imaging on PCI Outcomes in Cases Utilising Rotational Atherectomy: An Analysis of 8,417 Rotational Atherectomy Cases from the British Cardiovascular Intervention Society Database
Authors: Protty Majd B. , Gallagher Sean , Sharp Andrew S. P. , Farooq Vasim , Egred Mohaned , O’Kane Peter , Ludman Peter , Mamas Mamas A , Kinnaird Tim
Published: March 2022

Introduction. There is increasing evidence supporting the use of intracoronary imaging to optimize the outcomes of percutaneous coronary intervention (PCI). However, there are no studies examining the impact of imaging on PCI outcomes in cases utilising rotational atherectomy (RA-PCI). Our study examines the determinants and outcomes of using intracoronary imaging in RA-PCI cases including 12-month mortality. Methods. Using the British Cardiac Intervention Society database, data were analysed on all RA-PCI procedures in the UK between 2007 and 2014. Descriptive statistics and multivariate logistic regressions were used to examine baseline, procedural, and outcome associations with intravascular imaging. Results. Intracoronary imaging was used in 1,279 out of 8,417 RA-PCI cases (15.2%). Baseline covariates associated with significantly more imaging use were number of stents used, smoking history, previous CABG, pressure wire use, proximal LAD disease, laser use, glycoprotein inhibitor use, cutting balloons, number of restenosis attempted, off-site surgery, and unprotected left main stem (uLMS) PCI. Adjusted rates of in-hospital major adverse cardiac/cerebrovascular events (IH-MACCE), its individual components (death, peri-procedural MI, stroke, and major bleed), or 12-month mortality were not significantly altered by the use of imaging in RA-PCI. However, subgroup analysis demonstrated a signal towards reduction in 12-month mortality in uLMS RA-PCI cases utilising intracoronary imaging (OR 0.67, 95% CI 0.44–1.03). Conclusions. Intracoronary imaging use during RA-PCI is associated with higher risk of baseline and procedural characteristics. There were no differences observed in IH-MACCE or 12-month mortality with intracoronary imaging in RA-PCI.
Jiedu-Yizhi Formula Improves Cognitive Impairment in an Aβ25–35-Induced Rat Model of Alzheimer’s Disease by Inhibiting Pyroptosis
Authors: Wang Jiale , Zhu Xiaoting , Li Yuhui , Zhang Pengqi , Wang Tianye , Li Mingquan
Published: March 2022

Jiedu-Yizhi formula (JDYZF) is prescribed for the treatment of Alzheimer’s disease (AD) and was created by Jixue Ren, a master of traditional Chinese medicine, based on the “marrow deficiency and toxin damage” theory. In our clinic, this formula has been used for the treatment of AD for many years and has achieved good results. However, the mechanism by which JDYZF improves cognitive impairment has not been determined. In this study, we confirmed that orally administered JDYZF reversed the cognitive deficits in an Aβ25–35-induced rat model, increased the number of neurons in the hippocampal CA1 area, improved their structure, decreased the deposition of β-amyloid (Aβ), reduced the expression of proteins related to the NLRP3/Caspase-1/GSDMD and LPS/Caspase-11/GSDMD pyroptosis pathways, and reduced the levels of interleukin 1β (IL-1β) and IL-18, thereby inhibiting the inflammatory response. In addition, JDYZF exerted no hepatotoxicity in rats. In short, these results provide scientific support for the clinical use of JDYZF to improve the cognitive function of patients with AD.
Video Analysis and System Construction of Basketball Game by Lightweight Deep Learning under the Internet of Things
Authors: Yang Tianyu , Jiang Congmeng , Li Pengfei
Published: March 2022

With the explosive growth of sports video data on the internet platform, how to scientifically manage this information has become a major challenge in the current big data era. In this context, a new lightweight player segmentation algorithm is proposed to realize the automatic analysis of basketball game video. Firstly, semantic events are expressed by extracting group and global motion features. A complete basketball game video is divided into three stages, and a basketball event classification method integrating global group motion patterns and domain knowledge is proposed. Secondly, a player segmentation algorithm based on lightweight deep learning is proposed to detect basketball players, segment the players, and finally extract players’ spatial features based on deep learning to realize players’ pose estimation. As the experimental results indicate, when a proposed 2-stage classification algorithm is used to classify the videos, the accuracy of identifying layup, the shooting, and other 2-pointers are improved by 21.26% and 6.41%, respectively. And the accuracy of average events sees an improvement of 2.74%. The results imply that the 2-stage classification based on event-occ is effective. After comparing the four methods of classifying players, it is found that there is no significant difference among these four methods about the accuracy of segmenting. Nevertheless, when judged with the time that these methods take separately, FCN-CNN (Fully Convolutional Network-Convolutional Neural Network) based on superpixels has overwhelming advantages. The event analysis method of basketball game video proposed here can realize the automatic analysis of basketball video, which is beneficial to promoting the rapid development of basketball and even sports.
Does Digital Finance Induce Improved Financing for Green Technological Innovation in China?
Authors: Fan Weilin , Wu Haoqiang , Liu Ying
Published: March 2022

Sustained and stable external financing, affected by the financial environment, is a necessary condition to support the green technological innovation of enterprises. This paper focuses on the impact of bettering the financial environment of digital finance on enterprise green technological innovation, as well as the mediating role of financing costs and financial flexibility in this process. Using China’s data on manufacturing enterprises listed in Shanghai and Shenzhen from 2011 to 2018, the hypotheses are tested. The result suggests the following: (a) digital finance effectively promotes enterprises to carry out green technological innovation, specifically, the coverage and depth of digital finance can promote enterprises’ green technological innovation, but the degree of digitization has no significant impact; (b) digital finance improves the financial environment by making up the shortage of traditional financial system through reducing financing problems such as “financing difficulty,” “matching difficulty,” and “supervision difficulty,” which make effective contributions to enterprise green technological innovation; (c) financing costs negatively mediate the relationship between digital finance and enterprise green technological innovation, while financial flexibility positively mediates the relationship. Overall, our findings shed light on the role digital finance plays in shaping corporate environmental behavior—and ultimately innovation in sustainability—in financing constraint setting.
Regeneration of Chronic Rotator Cuff Tear in a Rabbit Model: Synergetic Benefits of Human Umbilical Cord Blood‐Derived Mesenchymal Stem Cells, Polydeoxyribonucleotides, and Microcurrent Therapy
Authors: Kwon Dong Rak , Kim Kang Lip , Moon Yong Suk
Published: March 2022

Objective. To investigate synergic therapeutic effects of combined injection of intralesional mesenchymal stem cells derived from human umbilical cord blood (UCB‐MSCs) and polydeoxyribonucleotide (PDRN) combined with microcurrent therapy (MIC) on full thickness rotator cuff tendon tear (FTRCTT) in rabbit models. Methods. Thirty‐two rabbit models were assigned to 4 different groups. FTRCTT in the supraspinatus tendon was created. After 6 weeks, 4 types of procedures (0.2 mL normal saline injection, group 1 (G1‐NS); 0.2 mL SC injection, group 2 (G2‐MSC); 0.2 mL SC and weekly four injections of 0.2 mL PDRN with sham MIC, group 3 (G3‐MSC+PDRN+sham MIC); and 0.2 mL SC and weekly four injections of 0.2 mL PDRN with MIC for four weeks, group 4 (G4‐MSC+PDRN+MIC)) were performed in FTRCTT. Gross morphologic and histological changes of proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule (PECAM‐1) and motion analysis were performed. Results. There was a significant difference in gross morphologic changes between baseline and week 4 posttreatment in group 4 compared to the other three groups (p = 0.01). In groups 3 and 4, all parameters of histochemical and motion analysis have been found to be significantly greater than the ones in groups 1 and 2 (p < 0.05). In group 4, PCNA‐, VEGF‐, and PECAM‐1‐stained cells, as well as walking distance, were significantly greater than the ones in group 3 (p < 0.05). Conclusion. The treatment with UCB‐MSCs and PDRN combined with MIC might be the most effective in rabbit models’ traumatic FRTCTT.
The Effect of Upcycled Brewers’ Spent Grain on Consumer Acceptance and Predictors of Overall Liking in Muffins
Authors: Combest Shannon , Warren Cynthia
Published: March 2022

The brewing industry generates large amounts of food waste including brewers’ spent grain (BSG) and leftover malted grains from beer production. BSG compositions can vary but consistently include high levels of protein and fiber. The potential nutritional and health benefits of BSG have sparked recent interest for food fortification. However, the challenges associated with BSG addition can impact food quality due to increases in fiber and protein content and reduction in starch content. Consumer testing was conducted to evaluate muffins containing varying levels of BSG (0, 20, 30% wt:wt flour) to determine the highest acceptable concentration on overall likeability, appearance, texture, moistness, sponginess, and taste attributes. Significant differences were found within appearance (F = 7.728, P = .001) and taste (F = 4.947, P = .008) ratings across all muffins. Control and 20% BSG muffins were rated significantly higher for appearance (6.74 ± 0.18; 6.64 ± 0.18) than 30% BSG muffins (6.11 ± 0.18). Muffins containing 20% BSG (7.15 ± 0.17) received significantly higher taste ratings than 30% BSG muffins (6.56 ± 0.22) and control muffins (6.49 ± 0.19). However, 30% BSG muffins maintained acceptance for all attributes showing higher allowable BSG substitutions than previously reported. Bivariate correlation analyses found that all attributes across each muffin variation were strongly, positively correlated (r > 0.6) with overall likeability excluding appearance (r = 0.359, P < 0.001) and moistness (r = .466, P < 0.001) in control muffins. Significant predictors of overall likeability were appearance (β = 0.088, P = 0.005), texture (β = 0.181, P < 0.001), sponginess (β = 0.226, P < 0.001), and taste (β = 0.494, P < 0.001). Brewers’ spent grain consumer acceptance results will guide the development of test food products for future human diet intervention compliance.
Prevention of Business Risks of Internet Information Security Platforms Based on Blockchain Technology
Authors: Yang Bingqing
Published: March 2022

The increasing maturity of Internet information technology has led to the rapid rise of blockchain technology. In essence, a blockchain is a shared database. In recent years, blockchain technology has attracted the attention of the public and society. With the continuous development of the market economy, many domestic enterprises have grown in size. At the same time, companies are also faced with various risks, and business risks will have a great impact on the company’s production. This article aims to prevent the business risk of Internet information security platform enterprises based on blockchain technology. Through the PoS algorithm, PoW algorithm, secure hash algorithm, and the principle of direct trust, the Internet information security platform is designed. Firstly, the platform is used for a business risk test with a small company, and the platform satisfaction survey is conducted on the employees of the company. The test results show that the subplatform design reduces the business risk of the company by 5%–10%, and employee satisfaction is high. The signature simulation of this algorithm under the same conditions as the SMRA and RSAR methods is also carried out. The results show that the performance of this algorithm is better. This study opens up a new path for small and medium-sized enterprises to prevent business risks.
Evaluation Method of Basketball Special Technology in College Sports Specialty Based on Genetic Algorithm
Authors: Chen Guining
Published: March 2022

Assessment is an important link and method in the teaching process, it can be used in teaching activities, obtaining feedback information for improving teaching methods, and guiding students to better master the knowledge and skills they have learned. This research mainly discusses the assessment and evaluation method of basketball special technology for college sports major based on genetic algorithms. In this paper, a genetic algorithm is proposed, aiming at the shortcomings of the genetic algorithm that can easily generate local optimal solutions, the genetic algorithm is improved, and the superiority of the algorithm is verified by comparative experiments. Finally, the algorithm is applied to the basketball professional skills assessment data and evaluation data to verify the practicability of the algorithm and my valuable information in a large amount of data in the assessment process. Based on the existing assessment basis, expert interviews, and questionnaire survey results in the assessment and evaluation methods of sports professional basketball special techniques, the necessity and basic principles of the innovation of the assessment and evaluation methods of special techniques are expounded. Then, by building a new system of assessment methods for basketball specialization in sports training majors, we can better explore the teaching objectives, teaching time, teaching content, teaching methods, organizational forms, teaching assessment and other aspects of basketball for sports majors in colleges and universities. Due to the complex nonlinear relationship between the technical evaluation results of basketball experts and professors and their influencing factors, as well as the unique advantages of genetic algorithms, it is feasible to introduce genetic algorithms into the field of basketball technical evaluation. There was no significant difference in the evaluation scores between the basketball special technology assessment model based on a genetic algorithm and the basketball skill assessment experts

P
>
0.05

. The scientific and effective technical test indicators for young basketball players can also objectively test the quality and effect of teaching and training for different age groups. It is a favorable tool for talent selection and plays a guiding role in grassroots youth basketball training. The content and methods stipulated by the test indicators directly affect the training content and methods of grassroots youth basketball players. This research helps to improve students’ basketball skills and tactics and comprehensive practice ability.
Strictly or Semitrivial Principal Eigensurface for

p
,
q

-Biharmonic Systems
Authors: Doumate Têlé Jonas , Leadi Liamidi , Toyou Lawouè Robert
Published: March 2022

This paper extends the eigensurface of

p

-bilaplacian operator to examine existence and simplicity of the first eigensurface for the third-order spectrum of

p
,
q

-biharmonic systems subject to boundary conditions.
Examining Potential of Scents for Enhancement of User Performance with Mobile Apps
Authors: Caro-Alvaro Sergio , Alkasasbeh Anas Ali , Garcia-Lopez Eva , Garcia-Cabot Antonio , Rozinaj Gregor , Ghinea Gheorghita
Published: March 2022

Intelligent mobile phones, or simply smartphones, have seen a large widespread usage among the entire world population during the last years. These devices are, in fact, considered as an essential tool in our current day to day life activities. Aromatherapy could be defined as the medical usage of essential oils derived from diverse types of vegetables. Although this paper does not look through direct medical usages or benefits, it is focused on one of its main effects, the stimuli to enhance focus. This study makes use of one of the main essential oils, rosemary, as olfactory stimuli over regular users performing a set of tasks with mobile apps. Results of the experimental group, when compared to regular users not affected with olfactory stimuli, aim to suggest that there is not a clear impact on mobile users’ performance. Nonetheless, more research is needed to categorize the effects of aromatherapy on mobile users.
Android Malware Detection Technology Based on Lightweight Convolutional Neural Networks
Authors: Ye Genchao , Zhang Jian , Li Huanzhou , Tang Zhangguo , Lv Tianzi
Published: March 2022

With the rapid development of Android, a major mobile Internet platform, Android malware attacks have become the number one threat to mobile Internet security. Traditional malware detection methods have low precision and greater time complexity. At present, image detection methods based on deep learning are used in malware detection. However, most of these methods are based on the largescale convolutional neural network model (such as VGG16). The computation and weight files of these models are very large, so they are not suitable for mobile Internet platforms with limited computation. A novel detection method based on a lightweight convolutional neural network is presented in this study. It transforms Android malware classes.dex, Androidmanifest.xml, and resource.arsc into RGB images and uses the lightweight convolutional neural network to extract the features of RGB images automatically. The experimental results of this study indicate that the method performs well in terms of precision and speed of detection.
Genomic and Computational Analysis of Novel SNPs in TNP1 Gene Promoter Region of Bos indicus Breeding Bulls
Authors: Anjum Kashif Hameed , Nadeem Asif , Javed Maryam , Ahmad Hafiz Ishfaq , Riaz Amjad , Shehzad Wasim , Azhar Jahanzaib , Bhutta Muhammad Fahad
Published: March 2022

Transition nuclear proteins (TNPs), the principal proteins identified in the condensing spermatids chromatin, have been found to play a key role in histone displacement and chromatin condensation during mammalian spermatogenesis. One such gene belonging to the TNP family called TNP1 gene is abundantly expressed in the regulation of spermatogenesis, and its sequence is remarkably well conserved among mammals. Genomic analysis, by sequencing and computational approach, was used to identify the novel polymorphisms and to evaluate the molecular regulation of TNP1 gene expression in Sahiwal cattle breeding bulls. DNA samples were sequenced to identify novel single nucleotide polymorphisms (SNPs) in the TNP1 gene. Modern computational tools were used to predict putative transcription factor binding in the TNP1 promoter and CpG islands in the TNP1 promoter region. In the TNP1 gene, four SNPs, three TATA boxes, and one CAAT box were identified. One CAAT box was discovered at 89 bp upstream of start site ATG. The computational analyses indicated that the polymorphisms inside the promoter sequence results in an added HNF-1 transcription factor binding site. In contrast, the other variations may remove the naturally occurring SRF transcription factor binding site. The CpG islands in the TNP1 promoter region were predicted to be absent by the MethPrimer program before and after SNP site mutations. These findings pave the way for more research into the TNP1 gene’s promoter activity and the links between these SNPs and reproductive attributes in the Sahiwal breeding bulls.
Analysis of Clinical Outcomes of Different Fertilization Methods in Patients with ≤3 Eggs Retrieved
Authors: Wang Shuang , Zhang Xiaoyan , Bao Hongchu , Cui Yuanqing
Published: March 2022

Objective. To explore the intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) method on the clinical outcomes of infertile women with ≤3 eggs retrieved. Study Design. We retrospectively analyzed a cohort of female patients who received IVF/ICSI to assist pregnancy with retrieved eggs ≤3. The general conditions, i.e., two pronuclei (2PN) fertilization rate, abnormal fertilization rate, high-quality embryo rate, cycle cancellation rate, pregnancy rate of fresh embryo transfer, cumulative pregnancy rate, and miscarriage were compared between the two groups. Results. When the number of retrieved eggs was one, the fertilization rate of 2PN was higher and the cycle cancellation rate was lower in the ICSI group than in the IVF group

P
<
0.05

. The pregnancy rates of fresh embryo transfer, frozen-thawed embryo transfer, and the cumulative pregnancy rate were all higher in the ICSI group than in the IVF group

P
<
0.05

. When the number of retrieved eggs was two, the pregnancy rate of frozen-thawed embryo transfer and cumulative pregnancy rate in the ICSI group were higher than those in the IVF group

P
<
0.05

. When the number of retrieved eggs was three, the fertilization rate of 2PN and the pregnancy rate of frozen-thawed embryo transfer were higher in the ICSI group than those in the IVF group (all

P
<
0.05

). Conclusions. For patients with one egg retrieved, ICSI fertilization can reduce abnormal fertilization rate and cycle cancellation rate and improve cumulative pregnancy rate significantly enhancing patients’ benefits. However, increasing the number of eggs retrieved decreases the advantages of ICSI fertilization.
Research on College English Classroom Teaching Model Based on Adaptive Genetic Algorithm
Authors: Yang Zhiling
Published: March 2022

While college English teaching is steadily changing from static knowledge transfer to dynamic language ability development, classroom activities centered on language application are becoming more and more important in cultivating students’ language application ability. In recent years, education has been paid more and more attention, the scale of university education has gradually expanded, the professional categories have become more and more complete, the curriculum has become larger and larger, and the number of students has grown by leaps and bounds. The teaching resources (teachers, classrooms, teaching equipment, etc.) and the workload of English teachers are increasing. In order to effectively improve the efficiency of college English teaching, the paper proposes to apply genetic algorithms to the actual English course scheduling problem in colleges, taking into account all the various hardware and software constraints and the expected course scheduling goals, so as to provide a clear and concise solution to the course scheduling problem plan (parallel search for optimal scheduling) and the design and coding structure of each genetic operator. Furthermore, this study creates a genetic algorithm-based English social platform and examines the design aspects of dynamic teaching models and classroom activities of college English students in the context of this paper.
Structural Feature-Preserving Point Cloud Denoising Method for Aero-Engine Profile
Authors: Yan Jieqiong , Zhou Laishui , Wang Jun , Wang Xiaoping , Liu Xia
Published: March 2022

The ex-service and old type aero-engines are valuable for education. In many cases, these aero-engines only have physical objects, but lack geometric models. This brings difficulties to talent cultivation. Therefore, the education department needs to reconstruct geometric models of above aero-engines. The laser scanning devices provide raw data of aero-engine profile, but noise directly affects reconstruction accuracy. In order to ensure that noise is removed without blurring or distorting structural features, a structural feature-preserving point cloud denoising method is proposed. The noisy point cloud is divided into casing feature data, pipeline feature data and complex shape feature data. According to shape characteristics of each feature data, three denoising networks are designed to estimate position correction vectors of noisy points and project them back onto underlying surfaces. Qualitative and quantitative experiments show that our method significantly outperforms state-of-the-art methods, both in terms of preservation and restoration of structural features.
Measured Analysis on Surface Deformation and Influence of Cutter Torque for Twin Shield Tunnelling in Silty Sand
Authors: Dong Yuqing , Ding Zhi , Jiang Yexiang , Chen Chunlai , Shen Wenming , Wang Yinze
Published: March 2022

In this study, the field measurement was conducted on the twin shield tunnelling in a shield section of Hangzhou Metro Line 6, where the surface deformation caused by twin shield tunnelling in the silty sand was obtained. The surface deformation law and the applicability of the twin‐line Peck formula in the silt area were analyzed. The relationship between the cutterhead torque and the surface deformation in the silty sand was identified. Furthermore, the differences in surface deformation of twin shield tunnelling in the Hangzhou soft soil area were discussed. The results show that the settlement process caused by twin shield tunnelling in silty sand is faster than that of soft soil and has no rebound phenomenon. The twin‐line Peck formula is suitable in silty sand, but the prediction of the latter line using this formula is slightly deviated because of the secondary disturbance effect. Due to the secondary disturbance of the soil caused by the construction of the latter line, the soil loss rate of the latter line is higher than that of the former line. Therefore, the reference ratio of the soil loss rate of the latter line and the former line is given. Furthermore, the cutterhead torque of the shield machine was found to be associated with the maximum instantaneous value of the surface deformation.
Deformation Analysis of Surrounding Rock of Deep Roadway by the Fluid Structure Coupling Model with MIDAS-GTS
Authors: Jiang Jun , Hou Zhengmeng , Hou Kepeng , Lu Yongfeng , Sun Huafen , Niu Xiangdong
Published: March 2022

In order to verify the universal applicability of the fluid structure coupling model to the analysis requirements of deep tunnels under the MIDAS-GTS geotechnical simulation environment, the study, together with several mining enterprises, carried out verification and analysis on the measured data of 107 deep tunnels in recent years. The reference group selects the mean value of the analysis results generated by the analysis model using the preferred nonfluid structure coupling model in the MIDAS-GTS environment. Finally, it is confirmed that the fluid structure coupling model group data have significant advantages over the reference group data within the buried depth of 550 ∼ 1450 m and the tunnel cross-sectional area of 45 ∼ 102 m2. Finally, it is considered that the fluid structure coupling model has universal applicability within the analysis range. It is suggested that, in the future work, for example, when the tunnel construction project within the above analysis scope needs to carry out the simulation analysis of roof displacement and anchor bolt tension, the fluid structure coupling model should be directly selected as the analysis model.
The European MAPPYACTS Trial: Precision Medicine Program in Pediatric and Adolescent Patients with Recurrent Malignancies
Authors: Berlanga Pablo , Pierron Gaelle , Lacroix Ludovic , Chicard Mathieu , Adam de Beaumais Tiphaine , Marchais Antonin , Harttrampf Anne C. , Iddir Yasmine , Larive Alicia , Soriano Fernandez Aroa , Hezam Imene , Chevassus Cecile , Bernard Virginie , Cotteret Sophie , Scoazec Jean-Yves , Gauthier Arnaud , Abbou Samuel , Corradini Nadege , André Nicolas , Aerts Isabelle , Thebaud Estelle , Casanova Michela , Owens Cormac , Hladun-Alvaro Raquel , Michiels Stefan , Delattre Olivier , Vassal Gilles , Schleiermacher Gudrun , Geoerger Birgit
Published: March 2022

MAPPYACTS (NCT02613962) is an international prospective precision medicine trial aiming to define tumor molecular profiles in pediatric patients with recurrent/refractory malignancies in order to suggest the most adapted salvage treatment. From February 2016 to July 2020, 787 patients were included in France, Italy, Ireland, and Spain. At least one genetic alteration leading to a targeted treatment suggestion was identified in 436 patients (69%) with successful sequencing; 10% of these alterations were considered “ready for routine use.” Of 356 patients with follow-up beyond 12 months, 107 (30%) received one or more matched targeted therapies—56% of them within early clinical trials—mainly in the AcSé-ESMART platform trial (NCT02813135). Overall, matched treatment resulted in a 17% objective response rate, and of those patients with ready for routine use alterations, it was 38%. In patients with extracerebral tumors, 76% of actionable alterations detected in tumor tissue were also identified in circulating cell-free DNA (cfDNA).

Significance:

MAPPYACTS underlines the feasibility of molecular profiling at cancer recurrence in children on a multicenter, international level and demonstrates benefit for patients with selected key drivers. The use of cfDNA deserves validation in prospective studies. Our study highlights the need for innovative therapeutic proof-of-concept trials that address the underlying cancer complexity.

This article is highlighted in the In This Issue feature, p. 1171
Power quality improvement and analysis of interconnected bus system with PMU using VSM-STATCOM
Authors: Kabra Preeti Nitin , Donepudi Sudha Rani
Published: March 2022

The traditional static synchronous compensator (STATCOM) present in the power grid to compensate instability problem will not be not able to maintain stability of the system due to fluctuations in point of common coupling (PCC) voltage and frequency variation that may result in poor synchronization of the grid. The solution for this is the improvement in conventional STATCOM to virtual synchronous machine–static synchronous compensator (VSM-STATCOM). In this paper an interconnected IEEE-14 bus system is considered for analysis with VSM-STATCOM for improvement in voltage profile on weakest bus of the system. In order to find the weakest bus, load flow analysis is carried out on the bus system using Newton Rapson method. A VSM-STATCOM is connected at that weakest bus in synchronization to the grid injecting reactive power. For the analysis a fault is introduced on any of the line and voltage profile of the weakest bus is observed with and without VSM-STATCOM. The VSM-STATCOM is also compared to a conventional control STATCOM which has no inertia module. A comparative analysis is carrier out with parameters of voltage magnitude and frequency of the weak bus taken into consideration. The magnitude and frequency parameters of conventional STATCOM and VSM-STATCOM are measured using phasor measurement units. The model is designed using MATLAB Simulink power systems library block sets with graphical user interface (GUI) environment.
Os Comediantes e a Associação dos Artistas Brasileiros
Authors: Vertchenko Henrique Brener
Published: March 2022

O artigo discute a formação do grupo Os Comediantes na década de 1930, inserindo-o no seio das propostas e ações artísticas da Associação dos Artistas Brasileiros (AAB). Apresentam-se, assim, apontamentos para um período fundamental no que se refere ao delineamento de projetos e debates artísticos e intelectuais que trariam reverberações na “gestação” do grupo teatral conhecido como fundador do teatro brasileiro moderno. Buscando os fragmentos da Associação, um ambiente cultural dinâmico, propiciador de circulações de ideias, consagrações e sociabilidades, objetiva-se o delineamento de processos sociais, imaginações artísticas e práticas que permitam entrever projetos e mecanismos de trabalho. Desse modo, pensar as conformações teóricas, sociais, políticas e espaciais em torno das quais se articulava a AAB, permite caracterizá-la como recorte exemplar de um campo cultural.
Entrevista com Ruggero Jacobbi (Roma, 13 de fevereiro de 1981)
Authors: Rabetti Maria de Lourdes
Published: March 2022

Tradução de entrevista concedida pelo senhor Ruggero Jacobbi, diretor da Società Italiana Autori Drammatici (Siad) e ex-diretor da Accademia Nazionale d’Arte Drammatica Silvio D’Amico, que viveu no Brasil de dezembro de 1946 a 1960, trabalhando como diretor junto a diversas companhias brasileiras, o TBC entre elas, como professor na Escola de Arte Dramática, em São Paulo, e como crítico teatral junto a diversos jornais no Rio, em São Paulo e no Rio Grande do Sul, onde criou um curso de teatro junto à Faculdade de Filosofia da Universidade Federal do Rio Grande do Sul.
O contributo de Luís de Lima para a cena brasileira moderna
Authors: Rodrigues Márcia Regina
Published: March 2022

O presente trabalho tem como objetivo evidenciar o contributo de Luís de Lima (1925-2002) para o desenvolvimento do teatro moderno no Brasil, nomeadamente o seu papel de primeiro tradutor e encenador das peças de Eugène Ionesco, considerando os dados acerca das condições e meios pelos quais se deram as suas traduções para as encenações e no âmbito teórico a abordagem da tradução teatral ao nível da encenação proposta por Patrice Pavis (2008).

Palavras-chave: Teatro moderno, Tradução teatral, Luís de Lima.
Blood Pressure Management for Ischemic Stroke in the First 24 Hours
Authors: Bath Philip M. , Song Lili , Silva Gisele S. , Mistry Eva , Petersen Nils , Tsivgoulis Georgios , Mazighi Mikael , Bang Oh Young , Sandset Else Charlotte
Published: March 2022

High blood pressure (BP) is common after ischemic stroke and associated with a poor functional outcome and increased mortality. The conundrum then arises on whether to lower BP to improve outcome or whether this will worsen cerebral perfusion due to aberrant cerebral autoregulation. A number of large trials of BP lowering have failed to change outcome whether treatment was started prehospital in the community or hospital. Hence, nuances on how to manage high BP are likely, including whether different interventions are needed for different causes, the type and timing of the drug, how quickly BP is lowered, and the collateral effects of the drug, including on cerebral perfusion and platelets. Specific scenarios are also important, including when to lower BP before, during, and after intravenous thrombolysis and endovascular therapy/thrombectomy, when it may be necessary to raise BP, and when antihypertensive drugs taken before stroke should be restarted. This narrative review addresses these and other questions. Although further large trials are ongoing, it is increasingly likely that there is no simple answer. Different subgroups of patients may need to have their BP lowered (eg, before or after thrombolysis), left alone, or elevated.
HEDEF PROGRAMLAMA İLE ÜRETİM PLANLAMASI VE BİR PLASTİK FİRMASINDA UYGULAMA
Authors: ŞENGÜL Hacer , KARAKIŞ Engin
Published: March 2022

Üretim planlaması, işletme yönetiminin çok önemli bir bölümüdür. İşletmeler üretim sürecinde doğru kararlar verebilmek için planlama sürecine ihtiyaç duyar ve bu süreçte üretimi nasıl gerçekleştireceklerini önceden projelendirir. Üretim sürecinin kaynakları ve çıktılarına dayalı olan planlama; koordinasyon, denetim, kontrol ve karar alma süreçlerini içeren bir faaliyet bütünüdür. Bu çalışmada, Çok Kriterli Karar Verme yöntemlerinden Analitik Hiyerarşi Prosesi ve Hedef Programlama yöntemi kullanılmıştır. Analitik Hiyerarşi Prosesi ile üretim planlamasında dikkate alınan kriterlerin önem ağırlıkları belirlenmiştir. Hedef Programlama ile Plastik Kalıp ve Enjeksiyon firmasının 2021 yılındaki üretim planı hazırlanmıştır. Değerlendirmeler sonucunda Analitik Hiyerarşi Prosesi ve Hedef Programlama yöntemlerinin bütünleşik olarak üretim planlamasında uygulanabilir yöntemler olduğu görülmüştür.
Effects of using Natural and Artificial Flowers in Flower Arrangement on Psychological and Physiological Relaxation
Authors: Yang Jae-Won , Lee Min-Sun , Joung Dawou , Park Bum-Jin
Published: March 2022

Background and objective The purpose of this study is to investigate the effects of using natural and artificial flowers in flower arrangement on psychological and physiological relaxation. Methods In order to clarify the effect of natural flowers in terms of physiological relaxation during flower arrangement work, heart rate variability (HRV) was measured while 15 people were conducting flower arrangement with natural flowers in comparison with artificial flowers. The State-Trait Anxiety Inventory (STAI), Symptom Checklist-90-Revised (SCL-90-R), Profile of Mood States (POMS), and semantic differential (SD) method were used during flower arrangement to investigate the psychological effects. Results The physiological relaxation of natural flowers shows that flower arrangement using with natural flowers during the first 5 minutes significantly inhibits sympathetic activity compared to artificial flowers. This result proves that flower arrangement using natural flowers reduces the tension and improve relaxation. As the results of examining the psychological effects, the STAI proves that flower arrangement using natural flowers can better reduce anxiety and relax the subjects than artificial flowers. The result of SCL-90-R test shows that flower arrangement using natural flowers can significantly reduce depression. The result of the POMS shows that flower arrangement using natural flowers can significantly reduce tension, anxiety and depression compared to artificial flowers. The result of the SD method shows that the subjects had a significantly more positive impression of flower arrangement using natural flowers than that using artificial flowers in terms of feeling ‘pleasant’ and ‘calm’. Conclusion The result imply that flower arrangement using natural flowers can be more effective for relaxation and recovery from stress and can improve relaxation and calmness of human body compared to artificial flowers.
Anomalous pigmentation in American primates: review and first record of a leucistic black howler monkey in southeast Mexico
Authors: Ramos-Luna Jorge , Alvarez-Velazquez María Fernanda , Chapman Colin A. , Serio-Silva Juan Carlos
Published: March 2022

Leucism is an aberration of color that occurs in individuals as a consequence of genetic mutations. Along with albinism and piebaldism, leucism is one of the most commonly reported types of chromatic anomalies in mammals, however, detailed descriptions of such conditions are rare. We report the first record of a leucistic black howler monkey (Alouatta pigra) in southern Mexico, an apparently healthy individual who was the male of a typical black howler group. Additionally, we compiled records of anomalous pigmentation in American primates published in peer-reviewed journals between 1960 and 2021, as well as social media posts regarding casual observations of individuals with such conditions. We found 11 scientific articles which described 13 records of anomalous pigmentation in a total of 44 individuals, from five species, three subspecies and one hybrid. Leucism was the most widely reported condition with six records. We discovered 19 online posts of 20 individuals with anomalous pigmentation, which included two species not reported in scientific literature. Our results suggest that anomalous coloration is not a significant threat to survival, but its occurrence raises interesting, and possibly alarming, questions about the causes of such conditions. We encourage researchers and civil society to formally report such observations of animals with color aberrations, to expand upon the understanding of this phenomenon and to get involved in the conservation of tropical forests.
Bureaucracy and Development in the Sudan
Authors: Assam Mukht Ar Al
Published: March 2022

With good education and a relatively high functional capability, Sudanese Public servants have had the potential to playa major role in the political and socio-economic development of their country. Unfortunately, all development plans since independence have failed to achieve their goals. This failure was caused by administrative inefficiency and obsolete structures, bureaucratic infighting, and the lack of co-ordination, leading to poor implemention and execution of government policies.
Development and the State In Post-Colonial Algeria
Authors: Tlemcani Rachid , Hansen William W.
Published: March 2022

This article analyses the role of Algerian bureaucracy in development. It shows that the Algerian state owns the significant means of production and has used the bureaucracy to implement its statist model of development. In doing so it has emphasized the development of heavy industry and the use of the most advanced technology available to promote it. It was hoped that with this model of development and the help of a skilled and trained bureaucracy, rapid industrial growth would transform the country's socio-economic structure sufficiently to absorb the masses of peasant labour and allow Algeria to produce anything it chooses. This model, however, failed to create jobs for the bulk of the Algerian population, led to heavy reliance on foreign capital, and created large pools of unemployed and under-employed. For two decades these problems were staved off when high oil prices shaped the relationship between bureaucracy and development. When oil prices went down drastically in the 1980s, they caused unrest and turmoil in Algeria and created an economic crisis which the State and its bureaucracy are currently trying to manage.
The American-Soviet Confrontation in Africa: Its Impact on the Politics of Africa
Authors: Clute Robert E.
Published: March 2022

Despite enormous Soviet arms supplies to Africa, the V.S. stressed economic assistance throughout the 1970s and did not increase arms shipments. However, the fall of the Shah of Iran, the leftist regime in Mozambique and the Soviet-Cuban military build-up in Ethiopia and Angola, completely changed V.S. strategy in the 1980s. American emphasis shifted to the Horn of Africa. Increased aid was funneled to Kenya, Somalia and the Sudan. Support for Southern Africa states was minimal. The Reagan administration viewed South Africa as a bulwark against Communism and the Namibian question became stalemated.
Religious Pluralism and the Theory and Practice of Secularism: Reflections on the Indian Experience
Authors: Tharamangalam Joseph
Published: March 2022

Despite India's long history of religious pluralism and relativistic patterns of thought and its declared policy of creating a secular and democratic society, religious strife has characterised all the major social upheavals in modern India. This paper examines the nature of Indian pluralism and secularism with a view to understanding why and how the two are not as congruent as they are held to be in the West. It focuses special attention on hierarchy as the specific modality of India's traditional pluralism, legitimated within the framework of a religiously sanctioned ideology. It argues that the present crisis in India's secularism is at on ce a crisis in India's hierarchical structure and a crisis in its religious culture. A genuinely democratic and socialist India requires a secularism that transcends the traditional Indian theory and practice of tolerant hierarchical pluralism and embraces a more universalistic, rational, humanistic, and nonreligious culture.
The Historical Basis of the Politics of Indigenous “Capitalism” In Sierra Leone
Authors: Mukonoweshuro Eliphas G.
Published: March 2022

One of the major problems faced by newly-independent African governments has been how to devise an economic strategy that would simultaneously reduce foreign domination of the economy while creating a viable indigenous entrepreneurial class. In Sierra Leone, the government attempted to overcome this dilemma through a three—pronged strategy: the creation of parastatals; the introduction of legislation designed to carve out and protect lucrative economic niches for indigenous entrepreneurs in the economy; and the creation of financial institutions to strengthen indigenous capital. All these strategies failed and by the 1980s the economy faced an unprecedented crisis.
Farm Size and the Adoption of Rice Production Technologies in Taiwan
Authors: Chen Chao-Lang , Hansen David O. , Flinn William L.
Published: March 2022

In this paper, we test a conventional predictive model of the diffusion of rice blasticides, using data from Taiwan. The model has modest predictive power, accounting for one third of the variation in adoption (R2 = .334). The impact of farm size on the model is assessed under the assumption that it reflects the impact of social structural constraints on individual farmers. Except for the relationship between total production and adoption, farm size was found to have little effect on the model. This may have occurred because of the relatively homogeneous farm population in Taiwan. For homogeneous populations, predictive models, which incorporate individual and psychological variables, appear appropriate to the extent that they refer to the adoption of low cost, unsophisticated technologies.