bluuebunny/crossref_metadata_2025 huggingface dataset:
The intention to share a sustainability communication about a tourism destination
Authors: Garcia de los Salmones Maria Del Mar , Herrero Angel , Martínez García de Leaniz Patricia
Published: September 2024

Purpose

This paper aims to analyse the determinants of the intention to share a post about an environmental issue posted by a tourism destination on Facebook. The authors use the stimulus-organism-response (SOR) model as a theoretical framework and consider cognitive variables (destination social responsibility, tourist social responsibility and three types of congruence) as antecedents of emotions and of the tourists’ response (intention to share). Specific factors related to the social platform (attachment and active use of social media) are also included.

Design/methodology/approach

The model was tested for two destinations with different positioning (green tourism versus sun and beach). For the sampling strategy, the authors conducted an online poll targeting Facebook users who had undertaken at least one trip in the previous year. The sample consisted of 1,001 individuals.

Findings

The empirical evidence obtained indicates that consumer–cause congruence is the most important variable for explaining the intention to share the post for both destinations, with the destination–cause congruence being non-significant. The authors also observed that active participation on the social network stimulated the intention to share this specific content.

Originality/value

Unlike prior research, this paper examined consumer motivators for engaging with online corporate social responsibility content for tourism destinations, specifically focusing on destination social responsibility in sustainable tourism. The model also incorporates three types of congruence, revealing variations in their impact on explaining the intention to share sustainability-related posts.
Analysis of payment methods in merger and acquisition deals within the United Kingdom
Authors: Omotesho Akindele Babatunde , Obadire Ayodeji Michael
Published: September 2024

Purpose

This study aims to examine the effects of payment methods used in mergers and acquisitions (M&A) conducted by UK companies spanning the period from 2007 to 2019.

Design/methodology/approach

The study used the estimated expected returns method to identify abnormal returns during the deal announcement period, applying event study analysis with both univariate and multivariate regression models to detect cumulative abnormal returns around the announcement timeframe.

Findings

The results show a short-term positive return increase for acquiring firms, controlling for deal-specific characteristics like target firm location and payment methods. The authors observed a preference for cash financing across domestic and cross-border transactions. Multivariate analysis revealed insignificance between payment methods and deal characteristics like cross-border acquisitions and diversification.

Research limitations/implications

The study’s focus on publicly traded firms in the UK and the absence of a comparative analysis across different regions and markets limits the sample size and may impact the generalizability of findings.

Practical implications

The study proposes three practical implications. Firstly, firms should tailor payment methods to each transaction, aligning with strategic goals to optimize value and mitigate risks. Secondly, decision-makers must prioritize comprehensive due diligence and strategic alignment throughout M&A processes to enhance success and maximize synergies. Finally, analysing broader strategic contexts and regulatory landscapes when structuring transactions enables goal attainment, such as market expansion or value creation.

Social implications

The study’s findings can promote transparency and accountability among corporate decision-makers in M&A transactions. Stakeholders can advocate for transparent decision-making processes, enhancing trust in corporate governance.

Originality/value

This study provides valuable insights into the impact of payment methods on shareholder value in M&A transactions involving UK companies, informing strategic decision-making and contributing to the understanding of corporate finance dynamics.
The concept that went viral: Using machine learning to discover charisma in the wild
Authors: Joosse Paul , Lu Yulin
Published: September 2024

The term “charisma” is recognized as sociology's most successful export to common speech. While sociologists habitually dismiss popular uses of the word, we address its vernacularity head on as a worthy object of study and as a potential resource for conceptual development. Using machine learning, we locate “charisma” within the wider discursive field out of which it arises (and continues to arise) across four corpora; namely: Weber’s major writings; social scientific research (123,531 JSTOR articles); and social media (“X”) posts containing of “charisma” (n=77,161) and its 2023 variant, “rizz” (n=85,869). By capturing meaning structures that discursively suspend “charisma” across multiple dimensions, we discern three spectra that help to distinguish charisma’s sociological and non‐sociological uses. Spectrum one differentiates perspectives which see charisma as having either a structural or individual‐level range of efficacy. Spectrum two differentiates indifferent/analytical perspectives on charisma from perspectives which see it as desirable but also morally conservative. Spectrum three differentiates between relational and individualized ontologies for charisma. We find that, rather than hewing closely to the Weberian formulation, social scientific uses exist in an intermediate position vis‐à‐vis these three spectra. Thus, scholars participate in what they otherwise criticize as charisma’s vulgarization. The article concludes with recommendations for how to constructively interact with ‘popular charisma.’
A conceptual refinement of ritual: The case of guanxi
Authors: Barbalet Jack
Published: September 2024

Informal affective bonding through which social resources are deployed, known as guanxi, is significant in social, political, and economic relationships in present‐day China. Guanxi is sociologically understood as a form of social network and also as a type of social exchange. In addition, guanxi is regarded as a kind of or derived from ritual practices. Ritual aspects of guanxi are critically examined. The concept of ritual is distinguished from Confucian li, with which guanxi is often associated. Rituals held to be supportive of guanxi are examined, three distinct conceptualisations of ritual are identified, and ritual is differentiated from social practice, ceremony, and rite. Finally, emotions in guanxi ritual are briefly discussed, comparing Collins' approach with an account from the early Chinese theorist Xunzi.
Cytomegalovirus tracheobronchitis mimicking lung cancer progression in a patient with lung adenocarcinoma: A case report
Authors: Hong Green , Han Sung Joon , Kim Kyung‐Hee , Park Dongil , Chung Chaeuk
Published: September 2024

Cytomegalovirus (CMV) commonly infects immunocompromised individuals, such as cancer patients. We present a case involving a 60‐year‐old male with Stage 3A lung adenocarcinoma and chronic obstructive pulmonary disease (COPD) diagnosed with CMV tracheobronchitis, initially suspected as cancer progression. Treatment with ganciclovir led to partial improvement in symptoms of shortness of breath and cough, as well as bronchoscopic findings. However, due to ganciclovir‐induced neutropenia, the therapy was switched to foscarnet. Distinguishing between cancer progression and infectious tracheobronchitis through physical examination and chest CT scans remains challenging. In lung cancer patients presenting with airway and bronchial narrowing along with ulcerative mucosal lesions, CMV infection should be considered. A bronchoscopic biopsy is crucial for accurate diagnosis and determining the appropriate treatment in these patients.
Experimental evaluation of an artificial anal sphincter based on biomechanical compatibility
Authors: Wang Minghui , Zhou Wei , Liu Yunlong , Yu Hongliu
Published: September 2024

Background

The artificial anal sphincter is a device used to treat patients with fecal incontinence who are unable to control their bowel movements on their own. Long‐term morphological changes in the tissue surrounding the artificial anal sphincter can cause biomechanical compatibility problems, which seriously affect the clinical application of the artificial anal sphincter.

Methods

In this paper, the superelasticity of shape memory alloys was utilized to design and fabricate a biomechanically compatible constant force clamping artificial anal sphincter. An in vitro simulation system was constructed to verify the effectiveness, safety, and constant force characteristics of the artificial anal sphincter.

Results

The experimental results demonstrated that the artificial anal sphincter could be effectively closed with no leakage of the liquid‐like intestinal contents, which are most likely to leak. The pressure of the artificial anal sphincter on the intestinal tube gradually increased and eventually became constant during closure, and the pressure value was always less than the intestinal blood supply pressure threshold.

Conclusions

In this paper, we designed an artificial anal sphincter based on biomechanical compatibility and the corresponding in vitro simulation experimental program and preliminarily verified the effectiveness, safety, and constant force characteristics of the artificial anal sphincter.
Leucocytosis during induction therapy with all‐trans‐retinoic acid and arsenic trioxide in acute promyelocytic leukaemia predicts differentiation syndrome and treatment‐related complications
Authors: Cicconi Laura , Bisegna Marialaura , Gurnari Carmelo , Fanciullo David , Piciocchi Alfonso , Marsili Giovanni , Minotti Clara , Scalzulli Emilia , Mandelli Bianca , Guarnera Luca , Perrone Salvatore , Ortu La Barbera Elettra , Mecarocci Sergio , Biagi Annalisa , Cenfra Natalia , Corbingi Andrea , Scerpa Maria Cristina , Venditti Adriano , Martelli Maurizio , Voso Maria Teresa , Breccia Massimo , Pulsoni Alessandro
Published: September 2024

All‐trans‐retinoic acid (ATRA) and arsenic trioxide (ATO) represent the standard of care for low‐intermediate risk acute promyelocytic leukaemia (APL). Leucocytosis during induction with ATRA‐ATO represents a common complication with an incidence of up to 60%. To identify predictive factors for this complication, we studied a cohort of 65 low‐intermediate risk APL patients treated with ATRA‐ATO in three highly specialized Italian centres. Overall, 39/65 (60%) patients developed leucocytosis, with a peak in leucocyte count being most frequent in the second week from diagnosis. All cases were successfully managed with hydroxyurea. Predictive factors for leucocytosis in univariate analysis were lower platelet counts (odds ratio [OR] 0.98, 0.97–1.00, p = 0.018), lower fibrinogen levels (OR 0.36, 0.17–0.66, p = 0.003), higher bone marrow blast infiltration (OR 1.03, 1.01–1.07, p = 0.021) and CD117 expression by flow (OR 1.04, 1.01–1.08, p = 0.012). Multivariate analysis confirmed lower levels of fibrinogen at diagnosis as the strongest predictive factor for the development of leucocytosis (OR 0.36, 0.15–0.72, p = 0.009). Differentiation syndrome (DS) occurred only in patients developing leucocytosis showing a strict correlation with rising leucocytes counts (16/39 vs. 0/26, p < 0.001). In addition, other treatment‐related complications including QTc prolongation, cardiac events, liver, and haematological toxicities were significantly more frequent in patients experiencing leucocytosis (22/39 vs. 3/26, p < 0.001). In conclusion, APL patients undergoing ATRA‐ATO therapy with lower fibrinogen levels and platelet counts at diagnosis and with a massive bone marrow blast infiltrate should be carefully monitored for the development of leucocytosis during induction. DS and other treatment‐related complications seem to occur almost exclusively in patients developing leucocytosis, who should necessarily receive DS prophylaxis and more intensive monitoring and supportive therapy to prevent treatment complications.
Readiness for behaviour change after gestational diabetes mellitus: A prospective cohort study
Authors: Sarma Shohinee , Bhatia Dominika , Yu Christina , Wu Wei , Lowe Julia , Ray Joel , Feig Denice S. , Lipscombe Lorraine L.
Published: September 2024

Aims

Women with gestational diabetes mellitus (GDM) have a high risk of developing type 2 diabetes (T2D). Readiness for behaviour change to mitigate this risk may be low after pregnancy and may further decrease over time without appropriate interventions. This study aimed to evaluate readiness for behaviour change in the first and second postpartum years in women with recent GDM to determine the best timing for lifestyle interventions to prevent T2D.

Methods

This study included a subset of women with GDM between 2009 and 2013 in Ontario, Canada from a larger prospective cohort study who completed a survey in the first and second postpartum years (N = 329). The primary outcome was stage of readiness for behaviour change for diet and physical activity, compared between the first and second postpartum years.

Results

The mean age was 34.3 ± 4.4 standard deviation (SD) years and mean pre‐pregnancy body‐mass index (BMI) was 26.7 ± 6.9 kg/m2. In the first postpartum year, 86% of women reported a pre‐action stage of change, which was 87% by the second postpartum year (p = 0.646). Non‐Caucasian ethnicity was associated with lower odds of being in the action stage of readiness for behaviour change overall and for physical activity in both time periods.

Conclusions

Most postpartum women with recent GDM are in a pre‐action stage of change after delivery, which does not increase by the second postpartum year. Behavioural interventions should continue to be prioritized in postpartum women with GDM to optimize this slim window of opportunity for T2D prevention.
‘Knock down the brain’: a nonlinear analysis of electroencephalography to study the effects of sub‐concussion in boxers
Authors: De Donato Renato , Maiorana Natale Vincenzo , Vergari Maurizio , De Sandi Angelica , Naci Anisa , Aglieco Giada , Albizzati Tommaso , Guidetti Matteo , Ferrara Rosanna , Bocci Tommaso , Barbieri Sergio , Ferrucci Roberta , Priori Alberto
Published: September 2024

Background and purpose

Boxing is associated with a high risk of head injuries and increases the likelihood of chronic traumatic encephalopathy. This study explores the effects of sub‐concussive impacts on boxers by applying both linear and nonlinear analysis methods to electroencephalogram (EEG) data.

Methods

Twenty‐one boxers were selected (mean ± SD, age 28.38 ± 5.5 years; weight 67.55 ± 8.90 kg; years of activity 6.76 ± 5.45; education 14.19 ± 3.08 years) and divided into ‘beginner’ and ‘advanced’ groups. The Montreal Cognitive Assessment and the Frontal Assessment Battery were administered; EEG data were collected in both eyes‐open (EO) and eyes‐closed (EC) conditions during resting states. Analyses of EEG data included normalized power spectral density (nPSD), power law exponent (PLE), detrended fluctuation analysis and multiscale entropy. Statistical analyses were used to compare the groups.

Results

Significant differences in nPSD and PLE were observed between the beginner and advanced boxers, with advanced boxers showing decreased mean nPSD and PLE (nPSD 4–7 Hz, p = 0.013; 8–13 Hz, p = 0.003; PLE frontal lobe F3 EC, p = 0.010). Multiscale entropy analysis indicated increased entropy at lower frequencies and decreased entropy at higher frequencies in advanced boxers (F3 EC, p = 0.024; occipital lobe O1 EO, p = 0.029; occipital lobe O2 EO, p = 0.036). These changes are similar to those seen in Alzheimer's disease.

Conclusion

Nonlinear analysis of EEG data shows potential as a neurophysiological biomarker for detecting the asymptomatic phase of chronic traumatic encephalopathy in boxers. This methodology could help monitor athletes' health and reduce the risk of future neurological injuries in sports.
Difference in trajectories according to early amyloid accumulation in cognitively unimpaired elderly
Authors: Kim Young Ju , Yun Jihwan , Seo Sang Won , Kim Jun Pyo , Jang Hyemin , Kim Hee Jin , Na Duk L. , Woo Sookyoung , Chun Min Young ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2024

Background and purpose

Amyloid β (Aβ), a major biomarker of Alzheimer's disease, leads to tau accumulation, neurodegeneration and cognitive decline. Modelling the trajectory of Aβ accumulation in cognitively unimpaired (CU) individuals is crucial, as treatments targeting Aβ are anticipated. The evolution of Aβ levels was investigated to determine whether it could lead to classification into different groups by studying longitudinal Aβ changes in older CU individuals, and differences between the groups were compared.

Methods

A total of 297 CU participants were included from the Alzheimer's Disease Neuroimaging Initiative database, and these participants underwent apolipoprotein E (APOE) genotyping, neuropsychological testing, brain magnetic resonance imaging, and an average of 3.03 follow‐up 18F‐florbetapir positron emission tomography scans. Distinct Aβ trajectory patterns were classified using latent class growth analysis, and longitudinal cognitive performances across these patterns were assessed with a linear mixed effects model.

Results

The optimal model consisted of three classes, with a high entropy value of 0.947. The classes were designated as follows: class 1, non‐accumulation group (n  = 197); class 2, late accumulation group (n  = 70); and class 3, early accumulation group (n  = 30). The late accumulation and early accumulation groups had more APOE ε4 carriers than the non‐accumulation group. The longitudinal analysis of cognitive performance revealed that the early accumulation group showed the steepest decline (modified Preclinical Alzheimer's Cognitive Composite with digit symbol substitution [mPACCdigit], p < 0.001; modified Preclinical Alzheimer's Cognitive Composite with trails B [mPACCtrailsB], p < 0.001) and the late accumulation group showed a steeper decline (mPACCdigit, p = 0.014; mPACCtrailsB, p = 0.007) compared to the non‐accumulation group.

Conclusions

Our study showed the heterogeneity of Aβ accumulation trajectories in CU older individuals. The prognoses for cognitive decline differ according to the Aβ trajectory patterns.
Effect of peroxide‐free and peroxide‐based in‐office bleaching on the surface and mechanical properties of CAD/CAM esthetic restorative materials
Authors: Alsarani Majed M. , Khan Aftab Ahmed , Bautista Leonel S. J. , Alsunbul Hanan , Matinlinna Jukka P.
Published: September 2024

The study aimed to investigate the influence of H2O2‐based and H2O2‐free in‐office bleaching on the surface and mechanical attributes of CAD/CAM composite blocks. CAD/CAM composite blocks from five different composite materials (CC1, CC2, CC3, CC4, and CC5) were randomly divided into two groups according to bleaching application (H2O2‐based and H2O2‐free). The surface topography, morphology, nanohardness, elastic modulus, flexural strength, and fracture toughness were measured. A paired and unpaired sample t‐tests gauged the effect of pre‐ and post‐bleaching on the substrates. The estimated mean differences (before‐after bleaching) suggested an increase in surface roughness for two materials CC2 and CC4, and a significant decrease in nanohardness for material CC4 and in elastic modulus for materials CC2 and CC4 with H2O2‐based bleaching, whereas H2O2‐free bleaching resulted in changes compatible with no change in these properties. Flexural strength and fracture toughness showed no evidence of changes, irrespective of the bleaching gel used. Scanning electron microscopic analysis revealed erosive effects and micropore formation due to H2O2‐based bleaching. H2O2‐based bleaching deteriorates the surface of CAD/CAM composite materials while H2O2‐free bleaching gel had an insignificant effect on both surface and bulk properties. The clinician should carefully evaluate the potential effects of H2O2‐based bleaching on the surface properties of CAD/CAM composites.
Centromedian thalamic deep brain stimulation for idiopathic generalized epilepsy: Connectivity and target optimization
Authors: Park Sihyeong , Permezel Fiona , Agashe Shruti , Osman Gamaleldin , Simpson Hugh D. , Miller Kai J. , Van Gompel Jamie J. , Starnes Keith , Lundstrom Brian N. , Worrell Gregory A. , Gregg Nicholas M.
Published: September 2024

There are limited treatment options for individuals with drug‐resistant idiopathic generalized epilepsy (IGE). Small, limited case series suggest that centromedian thalamus deep brain stimulation (CM‐DBS) may be an effective treatment option. The optimal CM‐DBS target for IGE is underexamined. Here, we present a retrospective analysis of CM‐DBS targeting and efficacy for five patients with drug‐resistant IGE. Volume of tissue activated (VTA) overlap with CM nucleus was performed using an open‐source toolbox. Median follow‐up time was 13 months. Median convulsive seizure frequency reduction was 66%. One patient had only absence seizures, with >99% reduction in absence seizure frequency. Four patients had electrode contacts positioned within the CM nucleus target, all of whom had >50% reduction in primary semiology seizure, with 85% median seizure reduction (p = .004, paired‐sample t test). Volumetric “sweet‐spot” mapping revealed that best outcomes were correlated with stimulation of the middle ventral CM nucleus. Connectivity strength between the sweet‐spot region and central peri‐Rolandic cortex was increased significantly relative to other cortical regions (p = 8.6 × 10−4, Mann–Whitney U test). Our findings indicate that CM‐DBS can be an effective treatment for patients with IGE, highlight the importance of accurate targeting and targeting analysis, and within the context of prior work, suggest that ideal CM‐DBS targets may be syndrome specific.
Heart rate variability in horses with and without severe equine asthma
Authors: Nyerges‐Bohák Zsófia , Kovács Levente , Povázsai Ágnes , Hamar Enikő , Póti Péter , Ladányi Márta
Published: September 2024

Background

Equine asthma in severe form (severe equine asthma [sEA]) shares remarkable similarities with human asthma. Human studies detected changes in the autonomic nervous system function in asthmatic patients based on heart rate variability (HRV) analysis.

Study design

Observational study.

Objectives

To investigate the relationship between sEA and HRV in horses.

Methods

Twenty horses diagnosed with sEA and 20 asymptomatic (non‐sEA) horses were investigated. SEA horses showed clinical signs. The RR intervals of the ECG were recorded for 1 h at rest between 9 AM and 11 AM using a heart rate (HR) monitor. HRV data were calculated using Kubios software. Parameters recorded for the sEA and non‐sEA groups were compared using one‐way MANOVA model. The significance level was set at α = 0.05.

Results

SD2 (mean 99.6 ± SD 25.3 vs. 42.5 ± 17.1), SDNN (82.7 ± 20.7 vs. 41.3 ± 14.3), TINN (398.1 ± 104.9 vs. 209.3 ± 71.9), SD2/SD1 ratio (1.7 ± 0.2 vs. 1.1 ± 0.3), Total power (4740.2 ± 1977.9 vs. 1503.0 ± 1179.3), LF (2415.3 ± 1072.4 vs. 707.4 ± 649.9), SD1 (60.9 ± 15.9 vs. 39.2 ± 14.1), RMSSD (86.0 ± 22.6 vs. 55.3 ± 19.8) and HF (1575.8 ± 902.5 vs. 578.1 ± 491.1) were lower in sEA horses compared with the non‐sEA horses (p < 0.01 for each variable). SD2, SDNN, TNN, the SD2/SD1 ratio and Total power showed the greatest discriminatory power in differentiating the sEA and non‐sEA groups.

Main limitations

Small sample size.

Conclusion

Our findings indicate that like humans, asthmatic horses show an overall reduction in autonomic control. A relative increase of the parasympathetic modulation of the heart was also observed. After further investigations, HRV measurement might be a non‐invasive approach to monitor autonomic nervous system responses of sEA horses.
MTFDN: An image copy‐move forgery detection method based on multi‐task learning
Authors: Liang Peng , Tu Hang , Hussain Amir , Li Ziyuan
Published: September 2024

Image copy‐move forgery, where an image region is copied and pasted within the same image, is a simple yet widely employed manipulation. In this paper, we rethink copy‐move forgery detection from the perspective of multi‐task learning and summarize two characteristics of this problem: (1) Homology and (2) Manipulated traces. Consequently, we propose a multi‐task forgery detection network (MTFDN) for image copy‐move forgery localization and source/target distinguishment. The network consists of a hard‐parameter sharing feature extractor, global forged homology detection (GFHD) and local manipulated trace detection (LMTD) modules. The difference of feature distribution between the GFHD module and the LMTD module is significantly reduced by sharing parameters. Experimental results on several benchmark copy‐move forgery datasets demonstrate the effectiveness of our proposed MTFDN.
The second glass ceiling: The dark side of women recategorization in corporate boards
Authors: Pascual‐Fuster Bartolomé , Federo Ryan , Crespí‐Cladera Rafel , Gabaldón Patricia
Published: September 2024

Previous research has shown evidence of the existence of glass ceilings, especially for women who face several barriers to reach the most powerful corporate positions. However, even when these women have reached the board, they seem to experience resistance within this group, a second glass ceiling that prevents them from being appointed to the most influential positions of the board. Based on categorization and recategorization theories and using a sample of publicly listed Spanish firms during the period 2004–2012, we find that women directors with characteristics that should facilitate their promotion to most board leadership and major board committee positions are not reaching them, that is, are not recategorized. Moreover, we uncover that it is also hard for women to attract more women and evolve into their own majority group, as the number of women directors does not increase when women are already directors in those boards.
Novel protocol for prevention from hepatitis B reactivation following living‐donor liver transplantation
Authors: Izumi Takuma , Toshima Takeo , Itoh Shinji , Yoshiya Shohei , Bekki Yuki , Iseda Norifumi , Tsutsui Yuriko , Toshida Katsuya , Nakayama Yuki , Ishikawa Takuma , Yoshizumi Tomoharu
Published: September 2024

Aim

Reactivation of hepatitis B virus (HBV) after liver transplantation (LT) remains a problem; thus, development of more effective HBV reactivation prophylaxis is desirable. We evaluated the efficacy of a combination of a long‐term nucleotide analog (NA), such as entecavir (ETV) or tenofovir alafenamide (TAF), and short‐term hepatitis B immunoglobulin (HBIG) in preventing HBV reactivation and compared it with conventional HBV prophylaxis.

Methods

Between February 1999 and August 2023, 135 patients underwent living‐donor liver transplantation for liver cirrhosis or acute liver failure caused by HBV infection or received an LT from a hepatitis B core antibody‐positive donor. Recipients who had undergone LT were classified as being in the first or second era (namely until September 2017 and from October 2017), respectively, and outcomes of prophylaxis against HBV reactivation were compared between the two eras.

Results

In the second era, recipients with HBV‐related disease or who had received hepatitis B core antibody‐positive liver received combination therapy with short‐term HBIG and an NA such as TAF and ETV long‐term. The duration of HBIG treatment was markedly shorter than in the first era in both categories of patients and HBIG could be discontinued in all cases. Surprisingly, we observed HBV reactivation in the first era, but not in the second era, in both groups.

Conclusions

We have established a protocol for prophylaxis against HBV reactivation using a combination of short‐term HBIG and long‐term NA. This protocol was found to be sufficient to prevent HBV reactivation after LT.
Multiple facets of diversity reveal different patterns and processes in aquatic arthropod communities across the world's most extreme high‐altitude treasure
Authors: Zhang Junqian , Li Zhengfei , García‐Girón Jorge , Ge Yihao , Heino Jani , Yang Jiali , Xiong Xiong , Ma Li , Xie Zhicai
Published: September 2024

Revealing the mechanisms underlying community organization has long been a central interest for ecologists and biogeographers. Recent findings have suggested that different dimensions of biodiversity may be shaped by contrasting ecological processes, offering complementary insights about community assembly. However, studies integrating multiple diversity facets across the Qinghai‐Tibetan Plateau (QTP) remain insufficient.

We combined multiple analytical frameworks to unravel the patterns (taxonomic, functional and phylogenetic) and correlates (local environment, land use and dispersal pathways) of aquatic arthropod diversity in lotic (stream) and lentic (wetland) ecosystems of the QTP.

We observed strong phylogenetic signals in most functional traits, pointing to the influence of evolutionary processes on these faunas.

Null models indicated that community structure in most streams and wetlands was mostly the result of random draws from the regional functional and phylogenetic species pool. The prevalence of stochasticity was most likely associated with the interplay of the paleogeographical history, the extremely harsh environmental conditions at high elevations and the subsequent impoverishment of the regional species pool.

However, some streams and wetlands also exhibited phylogenetic overdispersion and functional clustering, emphasizing the potential importance of competitive exclusion and habitat filtering, respectively.

Variation partitioning further revealed that both environmental filtering and dispersal limitation accounted for the spatial variation of diversity measures, with local environment overriding the effects of space and catchment land use.

Overall, this study improves our understanding of community organization and diversity patterns in environmentally extreme alpine catchments, with broad implications for the conservation and management of one of the world’s most important high‐altitude treasures.
Deep Learning‐Based Blood Abnormalities Detection as a Tool for VEXAS Syndrome Screening
Authors: De Almeida Braga Cédric , Bauvais Maxence , Sujobert Pierre , Heiblig Maël , Jullien Maxime , Le Calvez Baptiste , Richard Camille , Le Roc'h Valentin , Rault Emmanuelle , Hérault Olivier , Peterlin Pierre , Garnier Alice , Chevallier Patrice , Bouzy Simon , Le Bris Yannick , Néel Antoine , Graveleau Julie , Kosmider Olivier , Paul‐Gilloteaux Perrine , Normand Nicolas , Eveillard Marion
Published: September 2024

Introduction

VEXAS is a syndrome described in 2020, caused by mutations of the UBA1 gene, and displaying a large pleomorphic array of clinical and hematological features. Nevertheless, these criteria lack significance to discriminate VEXAS from other inflammatory conditions at the screening step. This work hence first focused on singling out dysplastic features indicative of the syndrome among peripheral blood (PB) polymorphonuclears (PMN). A deep learning algorithm is then proposed for automatic detection of these features.

Methods

A multicentric dataset, comprising 9514 annotated PMN images was gathered, including UBA1 mutated VEXAS (n = 25), UBA1 wildtype myelodysplastic (n = 14), and UBA1 wildtype cytopenic patients (n = 25). Statistical analysis on a subset of patients was performed to screen for significant abnormalities. Detection of these features on PB was then automated with a convolutional neural network (CNN) for multilabel classification.

Results

Significant differences were observed in the proportions of PMNs with pseudo‐Pelger, nuclear spikes, vacuoles, and hypogranularity between patients with VEXAS and both cytopenic and myelodysplastic controls.

Automatic detection of these abnormalities yielded AUCs in the range [0.85–0.97] and a F1‐score of 0.70 on the test set. A VEXAS screening score was proposed, leveraging the model outputs and predicting the UBA1 mutational status with 0.82 sensitivity and 0.71 specificity on the test patients.

Conclusion

This study suggests that computer‐assisted analysis of PB smears, focusing on suspected VEXAS cases, can provide valuable insights for determining which patients should undergo molecular testing. The presented deep learning approach can help hematologists direct their suspicions before initiating further analyses.
Maternal influences on offspring food allergy
Authors: Lee Hwa Yeong , Nazmul Tanuza , Lan Jinggang , Oyoshi Michiko K.
Published: September 2024

The prevalence of allergies has been globally escalating. While allergies could appear at any age, they often develop in early life. However, the significant knowledge gap in the field is the mechanisms by which allergies affect certain people but not others. Investigating early factors and events in neonatal life that have a lasting impact on determining the susceptibilities of children to develop allergies is a significant area of the investigation as it promotes the understanding of neonatal immune system that mediates tolerance versus allergies. This review focuses on the research over the recent 10 years regarding the potential maternal factors that influence offspring allergies with a view to food allergy, a potentially life‐threatening cause of anaphylaxis. The role of breast milk, maternal diet, maternal antibodies, and microbiota that have been suggested as key maternal factors regulating offspring allergies are discussed here. We also suggest future research area to expand our knowledge of maternal–offspring interactions on the pathogenesis of food allergy.
Hemodynamic phenotypes in chronic kidney disease patients based on linear regression of blood pressure parameters
Authors: Cierpka‐Kmieć Katarzyna , Khursa Raissa , Hering Dagmara
Published: September 2024

Classic and non‐classic cardiovascular (CV) risk factors accumulate in chronic kidney disease (CKD), contributing to vascular remodeling and hemodynamic abnormalities. This study aimed to determine hemodynamic phenotypes based on linear regression of blood pressure (BP) parameters in stage G3‐G4 CKD patients at very high CV risk. 24‐h ambulatory BP monitoring (ABPM), carotid‐femoral pulse wave velocity (PWV) and central BP were obtained from 52 patients (aged 60 ± 11 years, BMI 30 ± 6 kg/m2) with stage G3‐G4 CKD (eGFR 44 ± 12 mL/min./1.73 m2). Linear BP regression coefficients were generated to determine hemodynamic phenotypes using ABPM data. Coexisting hypertension was present in 45 (86%) patients, out of whom 33 (73%) had BP controlled. 24‐h mean systolic/diastolic BP was 128 ± 18/75 ± 12 mm Hg. Twenty‐six patients demonstrated the harmonious (H) and 26 patients diastolic dysfunctional (D) hemodynamic phenotypes. eGFR was not significantly different between both phenotypes. Compared to phenotype H, patients with phenotype D were older (57 ± 11 vs. 63 ± 10 years, p = .04), had higher PWV (8.2 [7.3–10.3] vs. 9.7 [8.3–10.9] m/s, p = .02), ambulatory arterial stiffness index (AASI) (0.31 ± 0.1 vs. 0.40 ± 0.1, p = .02), systolic BP (128 [122–130] vs. 137 [130–150] mm Hg, p = .001) and systolic BP variability (BPV) (11.7 ± 2.3 vs. 15.7 ± 3.4 mm Hg, p < .0001). Our findings suggest that one in two patients with stage G3‐G4 CKD demonstrates an unfavorable D hemodynamic phenotype based on a linear regression model, associated with higher PWV, AASI, systolic BP, and systolic BPV. Further studies are required to assess the clinical utility of hemodynamic phenotypes and whether the D phenotype may predict latent circulatory disorders and outcomes.
Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study
Authors: Ding Hong , Wang Jingtao , Liu Shu , Xie Yafei , Zhang Xiaowei , Yu Jing
Published: September 2024

The fibrosis‐4 index (FIB‐4) is a noninvasive fibrosis test that is recommended for patients who are at risk of developing hepatic fibrosis. The aim of the study was to explore the correlation between FIB‐4 index and the decline of cognitive function among older patients with hypertension. The study used a cross‐sectional design to analyze data obtained from the NHANES 2011–2014. The significance of the FIB‐4 index correlation with cognitive function in individuals over the age of 60 was evaluated via multivariate regression models. The nonlinear link was described and fitted smoothed curves. There were a total of 2039 participants in the study, and those with a higher FIB‐4 index were more susceptible to developing cognitive decline. In the completely adjusted model, the association remained statistically significant between the FIB‐4 index and poor cognitive function as measured by CERAD: Total Score (OR = 0.72, 0.57−0.91), Animal Fluency Score (OR = 0.66, 0.48−0.91), and Digit Symbol Score (OR = 0.36, 0.17−0.77). A nonlinear association was found between the FIB‐4 and poor cognitive ability: Total Score, CERAD: Score Delayed Recall, Digit Symbol Score, and Animal Fluency Score. In elderly patients with hypertension, a high FIB‐4 index is correlated with an increased prevalence of cognitive decline. Hence, the FIB‐4 index could potentially serve as a valuable tool for determining individuals with hypertension who are susceptible to both liver‐related complications and cognitive impairment.
Trends in child support receipt and regularity in the United States, 1996–2018
Authors: Pilarz Alejandra Ros , Cuesta Laura
Published: September 2024

Objective

This study examined trends in child support receipt and regularity in the U.S. from 1996 to 2018, as well as whether inequality in these child support outcomes has grown by mothers' education, marital status, and race.

Background

Child support from noncustodial fathers is an important income source for custodial mothers. Yet, many custodial mothers do not receive any child support or receive irregular payments. Demographic, economic, and policy changes over the past 20 years suggest custodial mothers' child support receipt, and especially regular receipt, may be declining, particularly among socioeconomically‐disadvantaged mothers.

Method

Using nationally‐representative data from the Panel Study of Income Dynamics, this study describes trends in child support receipt and regularity among custodial mothers (N = 11,456). Regression models were used to examine maternal and household characteristics associated with child support receipt and regularity and to examine how gaps in child support receipt and regularity by maternal characteristics have changed over time.

Results

Child support receipt and regularity declined by nearly 30% between 1996 and 2018. Any receipt, and especially regular receipt, declined by a larger margin for less‐educated and never married mothers relative to higher‐educated and married mothers, respectively.

Conclusion

Growing gaps in child support receipt and regularity by mothers' education and marital status likely contribute to economic inequality, highlighting the need for reforms in child support policy and the social safety net.
Understanding variations in LGBTIQ+ acceptance across space and time: The importance of norm perceptions and political dynamics
Authors: Sweigart Michael M. , Galván‐Hernández Danna , Hässler Tabea , Hegarty Peter , Kite Mary E. , Ofosu Eugene K. , Ünsal Banu C. , Eisner Léïla
Published: September 2024

The 21st century has seen dynamic social, legal, and political change regarding the rights and acceptance of lesbian, gay, bisexual, trans, intersex, and queer/questioning (LGBTIQ+) people. This article argues that social norm perceptions—perceptions of other people's opinions in a given social context—and the political dynamics that shape those perceptions are important for understanding differences in LGBTIQ+ acceptance across sociopolitical environments and time periods. Instead of emphasizing “actual” norms—people's opinions on average in different groups—we focus on norm perceptions since people often conform to the attitudes and behaviors held and endorsed by others to achieve social belonging and accuracy in their judgments. We review evidence regarding structural (e.g., laws and institutional decisions), group (e.g., social identities), and individual (e.g., ideology) factors that influence perceptions of, and conformity to, norms of LGBTIQ+ inclusion or exclusion. Drawing on this review, we consider how political dynamics—the ways that civic and political actors make salient, promote, and frame issues, values, and norms in contesting or maintaining the status quo—influence interpretations of, and responses to, norm signals, thus shaping differences in LGBTIQ+ rights norms across contexts and time periods. In conclusion, we chart future areas for research, policy, and practice.
Centering the margins: Reimagining resilience and resistance for transgender and nonbinary people of color
Authors: Bettergarcia Jay , Crone Cassandra , Herry Emily , Ali Bakhtawar
Published: September 2024

By centering the margins through intersectional and cross‐cultural perspectives, this article offers a reimagining of resilience by exploring individual versus collective (i.e., group‐level) approaches and strategies adopted by transgender and nonbinary people of color (TPOC) to resist oppression. We address the dynamics of multiple group membership and recognize the profound effects of culture on how TPOC communities navigate resilience and resistance. Utilizing an international perspective, we examine risk and resilience by considering proximal and distal minority stressors such as discrimination and internalized stigma. We also address the utility of current models used to address TPOC resilience (i.e., minority stress and resilience theory, transgender resilience intervention model). Finally, we address tensions associated with the characterization of resilience and resistance for TPOC within the social sciences and across cultures. This article thus serves as a critical foundation for reimagining research with TPOC by presenting potential avenues for further research, theory, and community action globally.
Lived Experience Perspective on Internalised Stigma and the EUPD Diagnosis
Authors: Mattocks Nicola
Published: September 2024

Introduction

EUPD (a personality disorder, characterised by emotion dysregulation, impulsivity and unstable relationships) is a controversial diagnosis affecting around 1 in 100 people, often times for a large part of their life, causing immense suffering to the individual and their families and friends.

Aim

As someone diagnosed with EUPD, I offer a lived experience perspective on internalised stigma building on growing attention to the impact of prejudice and discrimination faced when navigating the healthcare system with this diagnosis.

Implications for Practice

Include a recommendation to go ‘back to basics’ and focus on us (especially when accessing crisis care) feeling heard, seen, validated, empowered and understood.
Assessing the prospects and constraints of blockchain technology for intellectual property management
Authors: Kumar Dinesh , Suthar Nidhi
Published: September 2024

This study aims to assess the prospects and constraints of blockchain technology (BCT) for intellectual property management (IPM). It uses a qualitative method using existing literature related to BCT and IPM. Findings suggest that BCT has huge potential to transform IPM using BCT. The BCT can provide better transparency, security, and efficiency. BCT can be useful for increased transparency, trust, better licensing management, collaboration, innovation, and digital rights management. However, BCT has challenges in terms of standardization, interoperability, data privacy, security, accessibility, inclusivity, and integration with legacy systems. This paper will be useful for policymakers to implement the use of BCT in IPM.
Methods and Strategies of Microsurgery Combined with Ilizarov Technique in the Treatment of Amputation of Limbs in Renji Hospital: A Report of 51 Cases
Authors: Xie Shuqiang , Hou Jianxi , Wang Hongxin , Liu Weiqiang , Dong Qiqiang , Zhang Songjian , Yang Chaofan , Qin Sihe
Published: September 2024

Objective

Severe limb amputation trauma often results in bone and soft tissue defects after debridement. Traditional replantation aims to save the limb by shortening the ischemic period and using autologous transplantation for repair, but it can lead to surgical trauma, donor site damage, and prolonged operation time. Due to contusion, pollution, and complex injury, there is no unified standard for replantation and fixation. Improper operation can easily lead to complications such as bone infection, nonunion, bone defect, and joint stiffness. This study introduces the Ilizarov technique into microsurgery to improve limb lengthening after reconstruction and standardizes the steps of replantation fixation for complex limb avulsion injuries, with a focus on clinical efficacy.

Methods

A retrospective analysis was performed on 51 patients with complex limb amputation who were treated in Zhengzhou Renji Hospital from June 2009 to March 2021. On the basis of microsurgical limb replantation, Ilizarov technology was introduced to innovate the internal and external combined stepwise fixation method for replantation. Patients' gender, age, height, weight, BMI, and other general information were collected. X‐ray films were reviewed regularly to observe the surgical healing of fracture, that is, the degree of limb shortening. The lengthening time, carrying time after lengthening, follow‐up time, Dahl classification, Paley fracture healing classification, and Chen Zhongwei's replantation function score were used to evaluate the recovery of the affected limb.

Results

A total of 51 patients were included in this group, including 36 male patients and 15 female patients. All the amputated wounds were single limb amputation. In this group of patients, the hind limbs were shortened by 2–12.5 cm (5.32 ± 2.24) after replantation. A total of 44 patients whose hind limbs were shortened by more than 2.5 cm were treated with two‐stage Ilizarov lengthening for 1.5–5.5 months (3.19 ± 1.03). The carrying time was 3–7.5 months (4.25 ± 0.94), and the follow‐up time was 1–7.8 years (3.76 ± 1.69). Among the 49 survived patients, the Dahl grade of external fixation was less than Grade 2 in 89.8%. The excellent and good rate of Paley fracture healing classification was 89.8%. The excellent and good rate of Chen Zhongwei's limb replantation function classification was 79.6%.

Conclusion

Microsurgery combined with Ilizarov technique in the treatment of limb amputation injury, limb salvage reconstruction with internal and external combined step‐by‐step combined fixation, and one‐stage shortening and two‐stage limb lengthening can reduce the occurrence of osteomyelitis, bone defect and nonunion, expand the indications of limb replantation, improve the success rate of limb replantation, with satisfactory results, and facilitate the promotion of clinical techniques.
Geometric diagrams as an effective notation
Authors: Mumma John
Published: September 2024

In what way does a mathematical proof depend on the notation used in its presentation? This paper examines this question by analysing the computational differences, in the sense of Larkin and Simon's ‘Why a diagram is (sometimes) worth 10,000 words’, between diagrammatic and sentential notations as a means for presenting geometric proofs. Wittgenstein takes up the question of mathematical notation and proof in Section III of Remarks on the Foundations of Mathematics. After discussing his observations on a proof's ‘characteristic visual shape’ in Section III with respect to arithmetical proofs, the paper shows how the notion of a characteristic visual shape illuminates the special effectiveness of diagrammatic notation in geometry.