bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of A High-Performance Frit Glaze Using High-Potassium Feldspar
Authors: Huang Hongjun , Yu Junjie , Liu Fangfang , Zeng Haipeng
Published: January 2022

In this study, a lead-free transparent frit glaze was fabricated using a high potassium feldspar ore from Northeast China. The effect of the potassium feldspar grade and compositions of CaO and ZnO content on the performance of a block glaze was studied. The study on the effects of the potassium feldspar grade on the molten glaze demonstrated that as the grade of the potassium feldspar in glaze increases, the glaze appearance, gloss, hardness, and thermal stability of the sample become better, and the roughness decreases. CaO and ZnO in glaze have good fusible effects on the performance of melt glaze: the high-temperature viscosity of glaze decreases, and the surface tension and quality of the glaze increase. Moreover, an optimal lead-free frit glaze formula was determined, which provided insight into the production of high-added-value products using complex and refractory potassium feldspar ore.
Analysis of potentials and problems of Semarang city
Authors: Ridlo M A , Ghiffari A
Published: January 2022

Spatial planning very important and dynamic in meeting the needs of space that continues to increase in line with the rate of population growth. Urban infrastructure becomes very important and crucial in directing the development of the city. For Semarang City, infrastructure needs to be addressed immediately, especially in spatial planning. Is carried out thoroughly and taking into account the existing problems and potential. Rationalistic qualitative methods become the methodology in this study. The analysis tools used were, among others, the Administrative approach and the development approach with an environmental and sustainable perspective. An administrative approach was also used by reviewing applicable laws and links with coastal areas, such as law number 26 of 2007 concerning spatial planning; law number 27 of 2007 concerning Management of Coastal Areas and Small Islands. While the development approach is environmentally friendly and sustainable, it is an attempt to approach it by looking at the real conditions of the potential and problems of coastal areas, based on aspects of environmental and sustainable values. Therefore, the government should in every set development policies pay attention to the preservation of natural resources and the environment.
The biodiversity richness of Mollusk species in Lanaga waters, Meureubo Subdistrict, Aceh Barat Regency, Aceh Province
Authors: Sarong M A , Rizal M , Kusumawati I , Mursawal A , Hermi R , Zulfikar
Published: January 2022

Mollusca are soft-bodied animals that are generally protected by shells, and have a variety of species richness in habitat, especially in Lanaga Waters, Mereubo Subdistrict, Aceh Barat Regency and need to be studied through research. The research objectives were (1) to assess the number of species of each class, and (2) to analyse the level of species richness of each class of molluscs, which are found in Lanaga Waters, Meureubo Sub-district, Aceh Barat district, Aceh Province. The research was carried out from January to March 2021, in Lanaga Waters. The research area was divided into three locations, each location was divided into five stations, and each station was assigned five sampling plots. Data were taken by using the purposive sampling technique. Data analysis of species richness level was analysed by richness formula, and analysis of data about the number of each species in each class was carried out descriptively. The results showed that (1) the species of Molluscs belonging to the Gastropod class were 9 species with a richness index, the Bivalvia class contained 2 species with a species richness index of 0.13 to 0.90 indicating that the level of species richness was low to high, in the Lanaga Waters area. Mereubo Subdistrict, Aceh Barat Regency, Aceh Province.
Acanthaster coral predator density in the Pulau Dua area, Aceh Selatan
Authors: Ningsih R Z , Huda I , Sarong M A , Fitri H
Published: January 2022

The crown of thorns starfish is one of the main threats to damage to coral reefs worldwide. Research on Acanthaster coral predator density in the Pulau Dua area, South Aceh district, has been carried out in March 2021, using the Line Intercept Transect (LIT) method. The results showed that the density Acanthaster planci obtained 42 individuals/12.000m2 with natural criteria. Corals fractures can support the life of Acanthaster planci substrate conditions dominated by coral fractures. It can also grow thread algae (Coraline) and encrusting algae, which will then be eaten by Acanthaster planci which are still in the larval stage. This research concludes that the density of Acanthaster planci obtained is still in the natural category with coral reef conditions including good criteria.
A Numerical Approach of the Influence of Water Temperature in the Extinction of Fire Developed in Closed Spaces
Authors: Cozma P , Pavel D , Safta C A , Chisacof A
Published: January 2022

The aim of this work is to make a visual investigation of the fire behavior during the extinguish process with water mist at different temperatures, different diameters of the nozzle and different angles of diffusion jet, too. It was used a numerical simulation approach to analyze 24 scenarios regarding the influence of mist water in fire extinguish process. The main test was focused on a given enclosure with dimensions of 1.0 × 1.0 × 3.0 m and the fire source placed inside, in the middle. The enclosure is considered opened on the upper part. From the numerical simulation values, we concluded the best scenario in fire extinguish process using water mist.
The effect of using different Biodiesel fuels on jet development in a Diesel engine
Authors: Niculae Andrei Laurentiu , Chiriac Radu , Racovitza Alexandru
Published: January 2022

The fuel properties and the injection rate-shape play an important role in the improvement of the combustion process of Diesel engines. In this work, the influences of using the forthcoming renewable biodiesel fuels on fuel jet development utilizing a computer simulation model created with the AVL Hydsim software were studied. Biodiesel fuels B20, B30 and B100 were considered and compared with the original pure Diesel fuel D100. The injection system behaviour under research was that one existing on a tractor engine equipped with Delphi DP200 pump and Delphi injectors. Two engine speeds of 1400 rpm and 2400 rpm were considered representative for the engine operation. For these speeds, the fuel jet characteristics as penetration, spray cone angle and Sauter mean diameter were analyzed. It can emphasize that in similar conditions of needle lift and injection rate-shape variation the usage of biodiesel fuels does not significantly alter the injection pressure and the Sauter mean diameter. However, the specific physical properties of biodiesel fuels affect substantially the spray penetration and its cone angle.
Assessment of the Miller cycle operation in a spark ignition engine via 1D numerical simulation
Authors: Punov P , Niculae M , Clenci A , Mihalkov S. , Iorga-Siman V , Danlos A
Published: January 2022

The article presents the results of a 1D numerical simulation of a spark ignition engine developed to operate in Miller cycle. Miller cycle offers better thermal efficiency compared to Otto cycle due to higher volumetric expansion than compression, which in the current context is of paramount importance. In an engine with fixed geometric compression ratio, Miller cycle operation could be realized by means of either early intake valve closing (EIVC) or late intake valve closing (LIVC). Both cases lead however to a lower volumetric efficiency, thus reducing the indicating mean effective pressure, which in its turn results to a lower power output. The simulation’s aim is not only to assess the impact of implementing the Miller cycle but also to obtain the necessary results for imposing the boundary conditions in a 3D CFD simulation whose purpose is to analyse the influence of the Miller cycle on the internal aerodynamics of the engine.
Challenges and performance evaluation of livestock waste energy content
Authors: Halmaciu I A , Ionel I , Vetres I , Balogh R M , Bisorca D
Published: January 2022

The global increase of the population has generated more and more requirement of the animal-based food. In order to provide this requirement, it was necessary to increase considerably the actual numbers of animals. This has led to both numerous positive and negative effects brought both to people and animals. Creating agro-touristic farms, ensuring fresh food, creating workplaces are just a part of the factors which have beneficial effects on the human beings. Yet, a major problem, which should not be ignored and neglected, is represented by the wastes resulted from animal breeding. These superficially treated wastes can cause numerous negative effects on the whole ecosystem. The animal dejections, the water resulted from the meat processing, the animal corpses, and all represent biodegradable wastes, which might be used, by transforming their energy content into electrical and thermal energy. This can be possible, for example, by using these wastes as raw material for producing biogas. To prove their efficiency in producing the biogases there have been done thermal analysis. In this article are analysed, from a thermal point of view, 3 different samples. In the first part of the experiment were analysed the swine dejections, in the second part were analysed the poultry dejections, and the third experiment consisted in the analysis of the cow stable waste. The analysis of these samples was done with the help of the Netzsch 449 C Jupiter device. The results obtained from the analysis prove the fact that all the three raw materials can be used as raw materials in producing the biogas.
The use of microtechnology’s in the construction of water aeration installations
Authors: Boltinescu (Roza) Marilena Monica , BĂran Nicolae , Roza Albertino Giovani , Constantin Mihaela
Published: January 2022

Water aeration systems are highly efficient if the dispersion of air in the water is carried out in a controlled and uniform manner. The use of fine bubble generators ensures this and in addition, creates a small loss of pressure when air passes through them. The paper demonstrates that producing as few air bubbles as possible leads to a more efficient aeration process. Two water aeration installations are compared:

- The first has a perforated plate with 152 orifices Ø 0.1 mm;

- The second has four perforated plates, each with 113 orifices Ø 0.05 mm;

Both installations are successively supplied with the same flow rate of compressed air, at the same temperature and at the same initial dissolved oxygen concentration in the water.
Slam Algorithms for Different Map Representations
Authors: Titov R.U. , Motorin A.V.
Published: January 2022

The paper discusses the generalized simultaneous localization and mapping problem statement from the standpoint of the Bayesian approach and its relationship with algorithms for different map representations. The two-dimensional example describes the linearized simultaneous localization and mapping algorithm for the mobile platform in two-dimensional space.
Inferring dark matter substructure with astrometric lensing beyond the power spectrum
Authors: Mishra-Sharma Siddharth
Published: January 2022

Astrometry—the precise measurement of positions and motions of celestial objects—has emerged as a promising avenue for characterizing the dark matter population in our Galaxy. By leveraging recent advances in simulation-based inference and neural network architectures, we introduce a novel method to search for global dark matter-induced gravitational lensing signatures in astrometric datasets. Our method based on neural likelihood-ratio estimation shows significantly enhanced sensitivity to a cold dark matter population and more favorable scaling with measurement noise compared to existing approaches based on two-point correlation statistics. We demonstrate the real-world viability of our method by showing it to be robust to non-trivial modeled as well as unmodeled noise features expected in astrometric measurements. This establishes machine learning as a powerful tool for characterizing dark matter using astrometric data.
StainedGlass: interactive visualization of massive tandem repeat structures with identity heatmaps
Authors: Vollger Mitchell R , Kerpedjiev Peter , Phillippy Adam M , Eichler Evan E
Published: January 2022

The visualization and analysis of genomic repeats is typically accomplished using dot plots; however, the emergence of telomere-to-telomere assemblies with multi-megabase repeats requires new visualization strategies. Here, we introduce StainedGlass, which can generate publication-quality figures and interactive visualizations that depict the identity and orientation of multi-megabase tandem repeat structures at a genome-wide scale. The tool can rapidly reveal higher-order structures and improve the inference of evolutionary history for some of the most complex regions of genomes.

Availability and implementation

StainedGlass is implemented using Snakemake and available open source under the MIT license at https://mrvollger.github.io/StainedGlass/.

Supplementary information

Supplementary data are available at Bioinformatics online.
Milk and hygiene in Eastern France: the ‘goutte de lait’ at Besançon and the ‘œuvre du bon lait’ at Bar-le-Duc (late nineteenth to early twentieth centuries)
Authors: Knittel Fabien
Published: January 2022

Abstract—

Food security held a central place in the hygienist project to improve the quality of milk. While it may be difficult to grasp the question of milk and dairy products globally in hygienist discourse, this article proposes a focused study of two specific ‘œuvres de la goutte de lait’ (‘drop of milk’—the name given to specific social projects for milk quality) at Besançon and Bar-le-Duc in Eastern France. The ‘œuvre de la goutte de lait’ was an institution that sought to supply healthy milk to mothers who were unable to suckle their babies. This preoccupation with infant hygiene was allied to the development of pediatrics and childcare. Milk as a foodstuff was at the heart of the hygienist project of the turn of the twentieth century: on the one hand, it could carry tuberculosis, and was thus suspect; on the other, it provided an alternative to the problems of maternal breastfeeding. These projects helped contribute more broadly to the development of a municipal hygienics that was an essential characteristic of the emerging modern state in France.
The thermal structure of subduction zones predicted by plate cooling models with variable thermal properties
Authors: Morishige M
Published: January 2022

Previous modelling studies have investigated the effects of experimentally constrained thermal properties (i.e. thermal conductivity, specific heat and the thermal expansion coefficient) on the thermal structure of subduction zones. However, these studies have not carefully considered whether the assumed thermal structure of the slab before subduction is consistent with geophysical observations. This study investigates the effects of thermal properties on the thermal structure of the Tohoku subduction zone, northeast Japan, by using the slab temperature at the trench determined from plate cooling models. Three types of thermal properties were tested: constant, temperature-dependent and temperature- and lithology-dependent types. For each case, the parameters for the plate cooling models were inferred based on the observed surface heat flow and seafloor depth using Bayes’ theorem. It was found that the predicted temperature and location of phase boundaries in the slab, which are possibly related to intermediate-depth earthquakes, are similar for the three cases. This suggests that, in the Tohoku subduction zone, constant thermal properties can be used in modelling to examine phenomena related to slab dehydration. The depth uncertainties for isotherms in the oceanic plate and slab increase with temperature, and are about ±10 and ±20 km for the 600 and 1200 °C isotherms, respectively. When this uncertainty is considered, the location of the serpentinite-out boundary matches that of the lower plane of double seismic zone, suggesting that dehydration may be important in triggering intermediate-depth seismicity. However, the large uncertainty makes it difficult to discuss in detail the origins of intraplate earthquakes, the lithosphere–asthenosphere boundary, and the lower boundary of the slab in terms of temperature.
The anti-inflammatory mechanism of SAHA in acute pancreatitis through HDAC5/SLIT2/Akt/β-catenin axis
Authors: Tong Jinxue , Zhou Jiandang , Fang Min , Wang Gang , Fu Songbin , Sun Bei , Lv Jiachen
Published: January 2022

Acute pancreatitis (AP) is widely recognized to be an inflammation-related disease, in which HDAC was upregulated. The anti-inflammatory role of suberoylanilide hydroxamic acid (SAHA), a HDAC inhibitor, has been documented. In this context, this research was implemented to figure out whether SAHA manipulated inflammation in AP. Subsequent to induction of AP mouse model, HDAC5 expression was detected. The binding of HDAC5 and SLIT2 was detected by Co-Immunoprecipitation and Chromatin immunoprecipitation assays. SAHA treatment and gain- and loss-of-function approaches were used in AP mice and lipopolysaccharide (LPS)-induced pancreatic acinar cells. In mice, biochemical methods were implemented to measure activities of pancreatic lipase, trypsin, myeloperoxidase (MPO) and pancreatic edema, TUNEL staining to determine pancreatic cell apoptosis, and flow cytometry to assess the total number of leukocytes and neutrophils in pancreas. In pancreatic acinar cells, CCK-8 was performed to evaluate cell viability. HDAC5 exhibited overexpression in AP mice. Mechanical analysis showed that HDAC5 facilitated SLIT2 deacetylation to downregulate SLIT2, thus activating Akt/β-catenin pathway in pancreatic acinar cells. SAHA treatment, HDAC5 silencing or SLIT2 overexpression diminished inflammation in AP in vivo and in vitro. SAHA treatment, HDAC5 silencing or SLIT2 overexpression reduced activities of pancreatic lipase, trypsin, MPO, pancreatic edema and cell apoptosis in AP mice as well as elevated viability of LPS-induced pancreatic acinar cells. SAHA might exert anti-inflammatory effects in AP mice via HDAC5/SLIT2/Akt/β-catenin axis.
Conjoined twins after single blastocyst transfer: a case report including detailed time-lapse recording of the earliest embryogenesis, from zygote to expanded blastocyst
Authors: Grøndahl Marie Louise , Tharin Julie Elisabeth , Maroun Lisa Leth , Stener Jørgensen Finn
Published: January 2022

Conjoined twins are estimated to occur in 1:50 000 pregnancies. Eighteen cases of pregnancies achieved by ART have been published of which three were achieved after single embryo transfer, allowing discussion of embryo characteristics. We report, to the best of our knowledge, the first case of parapagus conjoined twins after ART. Furthermore, this is the first report of conjoined twins with detailed morphokinetics of the earliest embryogenesis from zygote to expanded and hatched blastocyst stage. The case zygote had three refractile bodies, which were all allocated to one blastomere at first cleavage following an asynchronous pronuclei fading. Within 2 h, this blastomere cleaved to four and fragmented. The remaining blastomere cleaved symmetrically and regularly and a blastocyst (score: 4AB) was vitrified 120 h after IVF. Pregnancy was achieved following a frozen-thawed single blastocyst transfer. The etiopathogenetic mechanism of the origin of conjoined twins is unknown and several hypotheses exist. The morphokinetics in the present case and morphology of other reported cases will be discussed in this context.
Monophosphoryl Lipid A Tolerance Against Chronic Stress-Induced Depression-Like Behaviors in Mice
Authors: Li Fu , Lu Xu , Ma Yaoying , Gu Yue , Ye Ting , Huang Chao
Published: January 2022

Backgrounds

Our recent studies reported that a single injection with lipopolysaccharide (LPS) before stress exposure prevents depression-like behaviors in stressed mice. Monophosphoryl lipid A (MPL) is a derivative of LPS that lacks the undesirable properties of LPS. We hypothesize that MPL can exert a prophylactic effect on depression.

Methods

The experimental mice were pre-injected with MPL before stress exposure. Depression in mice was induced through chronic social defeat stress (CSDS). Behavioral tests were conducted to identify depression-like behaviors. Real-time polymerase chain reaction and biochemical assays were performed to examine the gene and protein expression levels of pro-inflammatory cytokines.

Results

A single MPL injection 1 day before stress exposure at the dosages of 400, 800, and 1600 μg/kg but not 200 μg/kg prevented CSDS-induced depression-like behaviors in mice. This effect of MPL, however, vanished with the extension of the interval time between drug injection and stress exposure from 1 day or 5 days to 10 days, which was rescued by a second MPL injection 10 days after the first MPL injection or by a 4× MPL injection 10 days before stress exposure. A single MPL injection (800 μg/kg) before stress exposure prevented CSDS-induced increases in the gene expression levels of pro-inflammatory cytokines in the hippocampus and prefrontal cortex. Pre-inhibiting the innate immune stimulation by minocycline pretreatment (40 mg/kg) abrogated the preventive effect of MPL on CSDS-induced depression-like behaviors and neuroinflammatory responses in animal brains.

Conclusions

MPL, through innate immune stimulation, prevents stress-induced depression-like behaviors in mice by preventing neuroinflammatory responses.
Coordination in practice or performance? The political economy of refugee aid coordination in Jordan
Authors: Dhingra Reva
Published: January 2022

Political economy literature on the incentives of international actors during humanitarian crises has cast international aid coordination inefficiencies during humanitarian crises as a product of vertical principal–agent problems with informational asymmetries, divergent interests, and inter-agent competition. However, horizontal coordination between international actors represents an important and understudied dimension of the political economy of international aid during refugee responses. Horizontal coordination structures, while offering a potential solution to the principal–agent problem of humanitarian responses, can either result in coordination in practice or coordination in performance. I argue that the incentives of coordinating actors, the level of donor monitoring, and the risk of elimination of some organizations or material opportunities as a result of effective coordination all factor into international organization and international non-governmental organization coordination behaviour. I examine the relationships between stakeholders during the Syrian refugee response in Jordan and the differential take-up of coordination technologies to test my theory with policy implications.
Characterization of Long-range Aeromedical Transport and Its Relationship to the Development of Traumatic Extremity Compartment Syndrome: A 7-year, Retrospective Study
Authors: Maddry Joseph K , Mora Alejandra G , Perez Crystal A , Reeves Lauren K , Paciocco Joni A , Clemons Melissa A , Sheean Andrew , Kester Nurani M , Bebarta Vikhyat S
Published: January 2022

Background

Military aeromedical transport evacuates critically injured patients are for definitive care, including patients with or at risk for developing traumatic compartment syndrome of the extremities (tCSoE). Compartment pressure changes of the extremities have not been determined to be associated with factors inherent to aeromedical transport in animal models, but the influence of aeromedical evacuation (AE) transport on the timing of tCSoE development has not been studied in humans. Using a registry-based methodology, this study sought to characterize the temporal features of lower extremity compartment syndrome relative to the timing of transcontinental AE. With this approach, this study aims to inform practice in guidelines relating to the timing and possible effects of long-distance AE and the development of lower extremity compartment syndrome. Using patient care records, we sought to characterize the temporal features of tCSoE diagnosis relative to long-range aeromedical transport. In doing so, we aim to inform practice in guidelines relating to the timing and risks of long-range AE and postulate whether there is an ideal time to transport patients who are at risk for or with tCSoE.

Methods

We performed a retrospective record review of patients with a diagnosis of tCSoE who were evacuated out of theater from January 2007 to May 2014 via aeromedical transport. Data abstractors collected flight information, laboratory values, vital signs, procedures, in-flight assessments, and outcomes. We used the duration of time from injury to arrival at Landstuhl Regional Medical Center (LRMC) to represent time to transport. We compared groups based on time of tCSoE (inclusive of upper and lower extremity) diagnosis relative to injury day and time of transport (preflight versus postflight). We used descriptive statistics and multivariable regression models to determine the associations between time to transport, time to tCSoE diagnosis, and outcomes.

Results

Within our study window, 238 patients had documentation of tCSoE. We found that 47% of patients with tCSoE were diagnosed preflight and 53% were diagnosed postflight. Over 90% in both groups developed tCSoE within 48 hours of injury; the time to diagnosis was similar for casualties diagnosed pre- and postflight (P = .65). There was no association between time to arrival at LRMC and day of tCSoE diagnosis (risk ratio, 1.06; 95% CI, 0.96-1.16).

Conclusion

The timing of tCSoE diagnosis is not associated with the timing of transport; therefore, AE likely does not influence the development of tCSoE.
Different modes of spacer acquisition by the Staphylococcus epidermidis type III-A CRISPR-Cas system
Authors: Aviram Naama , Thornal Ashley N , Zeevi David , Marraffini Luciano A
Published: January 2022

CRISPR-Cas systems provide prokaryotic organisms with an adaptive defense mechanism that acquires immunological memories of infections. This is accomplished by integration of short fragments from the genome of invaders such as phages and plasmids, called ‘spacers’, into the CRISPR locus of the host. Depending on their genetic composition, CRISPR-Cas systems can be classified into six types, I-VI, however spacer acquisition has been extensively studied only in type I and II systems. Here, we used an inducible spacer acquisition assay to study this process in the type III-A CRISPR-Cas system of Staphylococcus epidermidis, in the absence of phage selection. Similarly to type I and II spacer acquisition, this type III system uses Cas1 and Cas2 to preferentially integrate spacers from the chromosomal terminus and free dsDNA ends produced after DNA breaks, in a manner that is enhanced by the AddAB DNA repair complex. Surprisingly, a different mode of spacer acquisition from rRNA and tRNA loci, which spans only the transcribed sequences of these genes and is not enhanced by AddAB, was also detected. Therefore, our findings reveal both common mechanistic principles that may be conserved in all CRISPR-Cas systems, as well as unique and intriguing features of type III spacer acquisition.
Elongation factor TFIIS is essential for heat stress adaptation in plants
Authors: Szádeczky-Kardoss István , Szaker Henrik Mihály , Verma Radhika , Darkó Éva , Pettkó-Szandtner Aladár , Silhavy Dániel , Csorba Tibor
Published: January 2022

Elongation factor TFIIS (transcription factor IIS) is structurally and biochemically probably the best characterized elongation cofactor of RNA polymerase II. However, little is known about TFIIS regulation or its roles during stress responses. Here, we show that, although TFIIS seems unnecessary under optimal conditions in Arabidopsis, its absence renders plants supersensitive to heat; tfIIs mutants die even when exposed to sublethal high temperature. TFIIS activity is required for thermal adaptation throughout the whole life cycle of plants, ensuring both survival and reproductive success. By employing a transcriptome analysis, we unravel that the absence of TFIIS makes transcriptional reprogramming sluggish, and affects expression and alternative splicing pattern of hundreds of heat-regulated transcripts. Transcriptome changes indirectly cause proteotoxic stress and deterioration of cellular pathways, including photosynthesis, which finally leads to lethality. Contrary to expectations of being constantly present to support transcription, we show that TFIIS is dynamically regulated. TFIIS accumulation during heat occurs in evolutionary distant species, including the unicellular alga Chlamydomonas reinhardtii, dicot Brassica napus and monocot Hordeum vulgare, suggesting that the vital role of TFIIS in stress adaptation of plants is conserved.
Differentiating perinatal Insomnia Disorder and sleep disruption: a longitudinal study from pregnancy to 2 years postpartum
Authors: Quin Nina , Lee Jin Joo , Pinnington Donna M , Newman Louise , Manber Rachel , Bei Bei
Published: January 2022

Study Objectives

Insomnia Disorder diagnoses require persistent sleep complaints despite “adequate sleep opportunity.” Significant Perinatal Sleep Disruption makes this diagnosis challenging. This longitudinal study distinguished between Insomnia Disorder and Perinatal Sleep Disruption and their sleep and mental health correlates.

Methods

One hundred sixty-three nulliparous females (age M ± SD = 33.35 ± 3.42) participating in a randomized controlled trial repeated the Insomnia Disorder module of the Duke Structured Interview for Sleep Disorders and Patient-Reported Outcome Measurement Information System measures for sleep and mental health at 30- and 35-weeks’ gestation, and 1.5, 3, 6, 12, and 24 months postpartum (944 interviews, 1009 questionnaires completed). We compared clinical features when Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Insomnia Disorder criteria (without the Duration criterion) were: (1) met (Insomnia Disorder), (2) not met only because of the sleep opportunity criteria (Perinatal Sleep Disruption), and (3) not met due to other criteria (Low Complaint).

Results

Proportions of Insomnia Disorder were 16.0% and 19.8% during early and late third trimester, and ranged 5.3%–11.7% postpartum. If the sleep opportunity criteria were not considered, rates of Insomnia would be 2–4 times higher (21.4%–40.4%) across time-points. Mixed-effects models adjusting for covariates showed that compared to Low Complaint, both Insomnia Disorder and Perinatal Sleep Disruption scored significantly higher on insomnia and sleep disturbance scales, sleep effort, and sleep-related impairments (p values < .01), but depression and anxiety were comparable (p values > .12).

Conclusion

Assessing sleep complaints without considering sleep opportunities can result in over-diagnosis of Insomnia Disorder in the perinatal periods. Insomnia Disorder and Perinatal Sleep Disruption were both associated with adverse sleep and mood outcomes, and need to be carefully differentiated and appropriately addressed.

Clinical Trial Registration: The SEED Project (Sleep, Eat, Emotions, and Development): A randomized controlled pilot study of a perinatal sleep intervention on sleep and wellbeing in mothers and infants. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=371634, Australian New Zealand Clinical Trials Registry: ACTRN12616001462471.
Social Disharmony and Racial Injustice: W. E. B. Du Bois’s Theories on Crime
Authors: Werth S Rose
Published: January 2022

Although W. E. B. Du Bois addresses crime in Black communities in many of his writings, he is rarely recognized as having a cohesive theory on crime, and his work is often conflated with Shaw and McKay’s social disorganization theory. While both social disorganization and Du Bois’s theories pushed sociology and criminology away from pseudo-biological explanations of crime to the social environment, the Chicago School analyzed how social control broke down within neighborhoods, while Du Bois analyzed how racist social and economic exclusion of Black communities led to crime. Du Bois’s criminological theories of social disharmony and racial injustice also consider the social construction of crime and the criminalization of Blackness where social disorganization does not. Focusing on the relations of racial exclusion led Du Bois to propose solutions to crime that focus on mechanisms of oppression and economic injustice across various levels of society. This approach differs widely from community-level interventions driven by social disorganization theory, which focus on improving informal social control within neighborhoods. Du Bois's theories on crime and the social environment provide an analytic lens for sociologists to link the social organization within communities to the social organization across communities.
Clinical Profile and Short-Term Outcome of SARS-CoV-2-Infected Neonates from a Government Medical College in West Bengal, India
Authors: Banerjee Mukut , Pal Jonaki , Mondal Tanushree , Ghosh Taraknath , Nayek Kaustav
Published: January 2022

Introduction

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to a terrifying global pandemic. The presentations in neonates are varied with less case severity compared to adults.

Aim

To describe the clinical and laboratory features and outcomes of neonates admitted with SARS-CoV-2 infection during the second surge of COVID-19 pandemic in a Government Medical College, West Bengal, India.

Materials and Methods

It is a hospital-based observational cross-sectional study conducted in the newborn unit of Burdwan Medical College and Hospital between 1 April 2021 and 31 July 2021 including all SARS-CoV-2 Real time RT-PCR (Reverse transcriptase polymerase chain reaction) positive neonates. The demographic, clinical and laboratory characteristics of all the neonates and their outcomes were documented and analysed.

Results

Twenty-two neonates were found to be SARS-CoV-2 RT-PCR positive out of which 9 (40.9%) were found to be asymptomatic and 6 (27.27%) required neonatal intensive care unit admissions. Among the symptomatic neonates, most common presentations were respiratory distress (40.9%) and gastrointestinal manifestations (40.9%). Eight (36.36%) neonates required respiratory support. Three (13.6%) neonates had pneumonia of which one had right middle lobe collapse. Laboratory parameters were nonspecific except for the two (9%) cases of multisystem inflammatory syndrome in neonates. High-resolution computed tomography findings in two cases were suggestive of SARS-CoV-2 infection-induced changes. Two (9%) neonates died of which one was likely due to SARS-CoV-2 infection.

Conclusion

Neonates with SARS-CoV-2 infection are mostly asymptomatic. However, clinicians must be vigilant as atypical presentations such as consolidation, collapse, meningitis or multisystem inflammatory syndrome may occur.
Development and Implementation of a Neonatal Pain Management Guideline for Minor Surgeries
Authors: David Lebanon , Forest Sharron
Published: January 2022

Background:

Although opioids are effective for neonatal postoperative pain management, cumulative opioid exposure may be detrimental. Pain management practices vary among providers, but practice guidelines may promote consistency and decrease opioid use.

Purpose:

To develop a pain management guideline (PMG) for neonates undergoing minor surgical procedures with the overarching goal of reducing opioid use without compromising the pain experience. The specific aim was for neonatal intensive care unit providers to adhere to the PMG at least 50% of the time.

Methods:

An interdisciplinary pain and sedation work group in a large level IV neonatal intensive care unit developed an evidence-based PMG for minor surgical procedures. Nurses and providers were educated on the new guideline, and rapid cycle quality improvement methodology provided an opportunity to adjust interventions over 3 months.

Results:

The PMG was used for 32 neonates following minor surgical procedures: 18 (56%) of the neonates received only acetaminophen and no opioids, 32% required 0.15 mg/kg dose equivalent of morphine or less, and only 9% required more than 0.15 mg/kg dose equivalent of morphine. Overall, opioid use decreased by 88% compared with rates before implementation of the PMG. Providers adhered to the PMG approximately 83.3% of time.

Implications for Practice:

A PMG is a systematic approach to direct nurses and providers to appropriately assess, prevent, and treat neonatal pain following minor surgery while alleviating opioid overuse.

Implications for Research:

Future research should focus on determining and mitigating barriers to nurse/provider use of the PMG and developing and implementing a PMG for major surgical procedures.
Trends in Venous Thromboembolism and Associated Risk Factors During Delivery Hospitalizations From 2000 to 2018
Authors: Krenitsky Nicole , Friedman Alexander M. , Yu Kathleen , Gyamfi-Bannerman Cynthia , Williams-Kane Jamila , O'Shaugnessy Fergal , Huang Yongmei , Wright Jason D. , D'Alton Mary E. , Wen Timothy
Published: January 2022

OBJECTIVE:

To characterize trends in and risk factors for venous thromboembolism (VTE) during delivery hospitalizations in the United States.

METHODS:

The 2000–2018 National Inpatient Sample was used for this repeated cross-sectional analysis. Venous thromboembolism (including deep vein thrombosis [DVT] and pulmonary embolism) during delivery hospitalizations for women aged 15 to 54 years was determined by year. Temporal trends in VTE were characterized using joinpoint regression with estimates presented as the average annual percent change. Temporal trends in common VTE risk factors were also analyzed. The proportion of vaginal and cesarean deliveries by year that had VTE risk factors was determined, and average annual percent changes with 95% CIs were calculated. The relationship between risk factors and the likelihood of VTE events was determined with adjusted and unadjusted logistic regression models.

RESULTS:

Of 73,109,789 delivery hospitalizations, 48,546 VTE events occurred (6.6/10,000 deliveries), including 37,312 DVT diagnoses and 12,487 pulmonary embolism diagnoses. Rates increased significantly for vaginal (average annual percent change 2.5%, 95% CI 1.5–3.5%) but not for cesarean delivery hospitalizations (average annual percent change 0.3%, 95% CI −1.0 to 1.6%) over the study period. Pulmonary embolism increased for both vaginal delivery (average annual percent change 8.7%, 95% CI 6.0–11.5%) and cesarean delivery (average annual percent change 4.9%, 95% CI 3.6–6.2%). The proportion of cesarean deliveries with at least one VTE risk factor increased from 27.2% in 2000 to 43.6% in 2018 (average annual percent change 2.6%, 95% CI 2.2–3.1%) and for vaginal deliveries, from 17.7% to 31.4% (average annual percent change 3.4%, 95% CI 2.3–4.4%). The 5.9% of deliveries with at least two VTE risk factor diagnoses accounted for 25.4% of VTE diagnoses. Factors with the highest VTE risk included transfusion (adjusted odds ratio [aOR] 4.1, 95% CI 3.7–4.5), infection (aOR 5.8, 95% CI 5.3–6.3), history of VTE (aOR 7.2, 95% CI 6.2–8.4), and thrombophilias (aOR 9.6, 95% CI 8.5–11.0).

CONCLUSION:

Both risk factors for VTE and rate of pulmonary embolism increased over the study period. Deep vein thrombosis increased during vaginal delivery hospitalizations but not during cesarean delivery hospitalizations.
Temporality and Patterns of Metastatic Recurrence in Node-Positive Breast Cancer Following Trimodality Therapy
Authors: Ariani Rojine , Hwang Lindsay , Maliglig Ana M. , Ragab Omar , Ye Jason C.
Published: January 2022

Objectives:

There is evidence that detection and treatment of oligometastases (≤5 lesions) may improve survival in breast cancer patients. However, there are no current national guidelines for screening of early, asymptomatic metastases. This study examined the patterns and timing of recurrence with respect to survival in node-positive breast cancer (NPBC) patients at higher risk for developing metastases.

Methods:

A single-institution retrospective review of NPBC patients treated with trimodality therapy was performed to collect patient and disease characteristics, recurrence location, method of detection, and survival outcome. Univariate and multivariate analyses were done to identify factors associated with recurrence.

Results:

Ninety-four NPBC patients treated at a safety-net hospital between 2008 and 2019 were identified. Twenty-one developed recurrence and were divided into oligometastatic (OM) (n=10) or diffusely metastatic (DM) (n=11) subgroups. Median recurrence-free survival in OM and DM was 18 and 36 months, respectively. Median overall survival (OS) for OM was not reached. Median OS for DM was 57 months. Four patients with OM progressed to diffuse disease in a median period of 17 months; median survival thereafter was 57 months. All patients with recurrence had distant metastases on initial detection, with the most common site being bone (14). Recurrence was most frequently detected by computed tomography (CT) (13), with the majority of disease located within the thorax region.

Conclusions:

All NPBC patients had distant metastasis at time of recurrence. Patients with OM had shorter interval to recurrence yet longer OS compared with DM. This study highlights improved surveillance imaging for timely detection of OM breast cancer that may yet be amenable to aggressive local salvage therapy to prevent progression to diffuse disease.
Efficacy and Safety of Trastuzumab Biosimilar (CT-P6) Compared With Reference Trastuzumab in Patients With HER2-positive Advanced Gastric Cancer
Authors: Park Joo-Hwan , Yeo Ja Hyun , Kim Young Saing , Park Inkeun , Ahn Hee Kyung , Cho Eun Kyung , Shin Dong Bok , Yang Jun-Young , Kim Hyung-Sik , Lee Woon Kee , Sym Sun Jin
Published: January 2022

Objectives:

Treatment with trastuzumab and chemotherapy significantly improves the outcome in patients with human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (AGC). CT-P6 (trastuzumab-pkrb; Herzuma) is a trastuzumab biosimilar approved for the treatment of HER2-positive gastric cancer. In this study, we aimed to compare the efficacy and safety of CT-P6 and reference trastuzumab as first-line treatment for HER2-positive AGC.

Materials and Methods:

The medical records of 102 patients with HER2-positive AGC treated with first-line trastuzumab-based chemotherapy were retrospectively reviewed. These patients were treated with either reference trastuzumab (n=72) or a biosimilar (n=30). Treatment outcomes, such as objective response rate, progression-free survival (PFS), and overall survival (OS), were compared between the reference and biosimilar groups.

Results:

The objective response rate of both groups (52.8% and 56.8% in the reference and biosimilar groups, respectively) were comparable (P=0.72). No statistically significant difference was observed with the reference versus biosimilar trastuzumab for PFS (median PFS, 6.9 vs. 5.4 mo; P=0.98) or OS (median OS, 12.3 mo vs. not reached; P=0.42). Safety profiles were similar between the 2 groups.

Conclusions:

Biosimilar trastuzumab showed equivalent outcome to reference trastuzumab, with similar adverse events. Biosimilar trastuzumab can suitably and safely replace trastuzumab as a reference for the treatment of HER2-positive AGC.
Inflammation Subtypes and Translating Inflammation-Related Genetic Findings in Schizophrenia and Related Psychoses: A Perspective on Pathways for Treatment Stratification and Novel Therapies
Authors: Bishop Jeffrey R. , Zhang Lusi , Lizano Paulo
Published: January 2022

Dysregulation of immunological and inflammatory processes is frequently observed in psychotic disorders. Numerous studies have examined the complex components of innate and adaptive immune processes in schizophrenia and related psychoses. Elevated inflammation in these conditions is related to neurobiological phenotypes and associated with both genetics and environmental exposures. Recent studies have utilized multivariate cytokine approaches to identify what appears to be a subset of individuals with elevated inflammation. The degree to which these findings represent a general process of dysregulated inflammation or whether there are more refined subtypes remains unclear. Brain-imaging studies have attempted to establish the link between peripheral inflammation and gray matter disruption, white matter abnormalities, and neuropsychological phenotypes. However, the interplay between peripheral inflammation and neuroinflammation, as well as the consequences of this interplay, in the context of psychosis remains unclear and requires further investigation. This Perspectives article reviews the following elements of immune dysregulation and its clinical and therapeutic implications: (1) evidence supporting inflammation and immune dysregulation in schizophrenia and related psychoses; (2) recent advances in approaches to characterizing subgroups of patients with elevated inflammation; (3) relationships between peripheral inflammation and brain-imaging indicators of neuroinflammation; (4) convergence of large-scale genetic findings and peripheral inflammation findings; and (5) therapeutic implications: anti-inflammation interventions leveraging genetic findings for drug discovery and repurposing. We offer perspectives and examples of how multiomics technologies may be useful for constructing and studying immunogenetic signatures. Advancing research in this area will facilitate biomarker discovery, disease subtyping, and the development of etiological treatments for immune dysregulation in psychosis.
Family Accommodation of Symptoms in Adults With Obsessive-Compulsive Disorder: Factor Structure and Usefulness of the Family Accommodation Scale for OCD–Patient Version
Authors: La Buissonnière-Ariza Valérie , Guzik Andrew G. , Schneider Sophie C. , Cepeda Sandra L. , Goodman Wayne K. , Storch Eric A.
Published: January 2022

For individuals with obsessive-compulsive disorder (OCD), family accommodation of symptoms, such as over-reassurance, participation in rituals, or facilitation of avoidance, is one of the key factors associated with symptom severity, maintenance, and related impairment. Most studies have assessed accommodation behaviors based on reports from family members or other loved ones. Recently, a patient-rated questionnaire, the Family Accommodation Scale for OCD–Patient Version (FAS-PV) was developed to assess family accommodation from the patient’s perspective. This study investigated the factor structure of the FAS-PV and clinical variables associated with patient-reported family accommodation in a sample of 151 treatment-seeking adults with OCD. A confirmatory factor analysis suggested that a 4-factor model best characterized the scale, with the following factors: (1) participation in symptoms, (2) avoidance of OCD triggers, (3) taking on responsibilities, and (4) modifying responsibilities. Internal consistency was high for the total score and for scores on the 4 subscales of the FAS-PV. Approximately 87% of the sample reported accommodation behaviors at some level. Family accommodation was positively correlated with OCD symptom severity and functional disability, and partially mediated the associations between these 2 factors, so that greater OCD severity was associated with greater accommodation, which, in turn, was associated with greater disability. Our findings parallel those of studies that have employed other versions of the FAS and suggest that the FAS-PV is a useful tool for assessing family accommodation of OCD symptoms from the patient’s perspective.
An Individual With 2 Distinct Nonpathologic Identities
Authors: Preskorn Sheldon H.
Published: January 2022

This article presents the case of a Vietnamese-American medical student who had 2 distinct identities which were not due to a pathologic process but rather were the result of learning. This case illustrates the complexity of brain function which is fundamental to psychiatry.