bluuebunny/crossref_metadata_2025 huggingface dataset:
Perancangan dan Pembuatan Aplikasi Permainan Petualangan "Gatotkaca Dalam Perang Baratayuda"
Authors: Andika Hermawan , Soetarmono Anggya N.D.
Published: April 2019

Gatotkaca merupakan salah satu tokoh pewayangan yang sangat populer di Indonesia. Game atau yang biasa disebut permainan merupakan aktivitas terstruktur atau semi terstruktur yang biasanya bertujuan untuk menghibur. Dengan memanfaatkan media permainan untuk mengenalkan sejarah pewayangan, menjadi tujuan utama penulis dalam melestarikan budaya Indonesia. Pengembangan permainan ini akan menggunakan framework starling, dengan hasil berupa aplikasi yang dapat dimainkan melalui web dan mobile phone (android & i-phone). Aplikasi permainan ini merupakan penggabungan antara visual novel game dan action game. Melalui visual novel game pemain dapat mengenal sejarah gatotkaca dalam perang Baratayuda. Sedangkan dari action game pemain dihibur dengan beberapa pola permain yang beragam.
Desain Infrastruktur dan Pemanfaatan Cloud Computing di Perusahaan Berskala Kecil Menengah sebagai Pendukung Kegiatan Operasional
Authors: Sundoro David
Published: April 2019

Pemanfaatan teknologi informasi dalam berbagai bidang industri. Namun perkembangan teknologi yang juga begitu cepat, membuat banyaknya variasi pilihan teknologi yang bisa dipergunakan sebagai solusi. Penelitian kali ini, menyajikan pemilihan teknologi yang bisa menjadi alternatif bagi penggunaan teknologi sebelumnya yang sudah diimplementasikan, tanpa mengorbankan kebutuhan dari badan usaha yang mempergunakan teknologi informasi tersebut. Sehingga di dalam menerapkan suatu teknologi, perlu memperhatikan kebutuhan yang sebenarnya dari bisnis yang dijalankan.
Analisis Pemilihan Penerapan Proyek Metodologi Pengembangan Rekayasa Perangkat Lunak
Authors: Budi Darmawan Setiya , Siswa Taghfirul Azhima Yoga , Abijono Heri
Published: April 2019

Metodologi merupakan kerangka pijakan utama dalam perancangan dan pengembangan perangkat lunak profesional untuk menghasilkan sebuah sistem informasi yang sesuai dengan kebutuhan bisnis sebuah organisasi. Keberhasilan pengembangan perangkat lunak bergantung pada pengelolaan proyek perangkat lunak secara keseluruhan. Tidak ada metodologi yang benar-benar sesuai dengan semua jenis organsasi, sehingga dibutuhkan pendekatan lebih lanjut untuk memilih metodologi mana yang paling sesuai untuk dapat diterapkan pada organisasi tertentu. Paper ini menjelaskan dan menganalisa metodologi pengembangan perangkat lunak yang meliputi: Linear Sequential Model atau Waterfall, Parallel Model, Iterative Model, Prototyping Model, RAD (Rapid Application Development) Model, Spiral Model, VShaped Model dan Agile Development untuk membuat perbandingan yang menunjukan kelebihan dan kelemahan masing-masing. Hasil paper ini menunjukan pertimbangan pemilihan metodologi yang didasarkan pada faktor-faktor kriteria penilaian yang terdiri dari kejelasan persyaratan pengguna, keakraban dengan teknologi, kompleksitas sistem, sistem keandalan, jadwal waktu singkat dan visibility jadwal hingga mereferensi beberapa pendapat dari jurnal ilmiah.
Perancangan dan Pembuatan Aplikasi Permainan Nusantara Indonesia Berbasis Android
Authors: Hartono Claudia Agustina , Andika Hermawan , Trianto Edwin Meinardi
Published: April 2019

Game atau yang biasa disebut permainan merupakan aktivitas terstruktur atau semi terstruktur yang biasanya bertujuan untuk menghibur. Penulis mengembangkan suatu permainan berbasis android dengan judul "Nusantara Indonesia" dengan tujuan mengenalkan budaya di Indonesia yang semakin hilang. Pengembangan permainan ini menggunakan framework Starling dan aplikasi Adobe Flash Builder. Beberapa fitur dalam permainan ini adalah fitur touch, swipe, dan gyro yang membuat permainan menjadi menarik untuk dimainkan. Terdapat pula cerita yang berperan sebagai media informasi mengenai budaya Indonesia.
An efficient synthesis of the guaiane sesquiterpene (−)-isoguaiene by domino metathesis
Authors: Wang Yuzhou , Darweesh Ahmed F , Zimdars Patrick , Metz Peter
Published: April 2019

(−)-Isoguaiene was prepared from (S)-citronellal in only 9–10 steps with good overall yields. Either a trienyne or a dienediyne metathesis and highly diastereoselective organocatalytic Michael additions of aldehydes derived from (S)-citronellal served as the key transformations.
Evolution of the Progenitors of SNe 1993J and 2011dh Revealed through Late-time Radio and X-Ray Studies
Authors: Kundu E. , Lundqvist P. , Sorokina E. , Pérez-Torres M. A. , Blinnikov S. , O’Connor E. , Ergon M. , Chandra P. , Das B.
Published: April 2019

We perform hydrodynamical simulations of the interaction between supernova (SN) ejecta and circumstellar medium (CSM) for SN 1993J and SN 2011dh, and calculate the radio and X-ray emissions expected from the shocked gas at late epochs (t). Considering the ejecta structure from multi-group radiation hydrodynamics simulation, we find that the observed rapid drop in radio and X-ray light curves of SN 1993J at t > 3000 days may be due to a change in the mass-loss rate (

) ∼6500 yr prior to the explosion of the SN. The exact epoch scales inversely with the assumed wind velocity of v
w = 10

. The progenitor of this SN very likely belonged to a binary system, where, during its evolution, the primary had transferred material to the secondary. It is argued in this paper that the change in

 can happen because of a change in the mass accretion efficiency (η) of the companion star. It is possible that before ∼6500 (v
w/10

)−1 yr prior to the explosion, η was high, and thus the CSM was tenuous, which causes the late-time downturn in fluxes. In the case of SN 2011dh, the late-time evolution is found to be consistent with a wind medium with

/v
w = 4 × 10−6

/10

. It is difficult from our analysis to predict whether the progenitor of this SN had a binary companion; however, if future observations show a similar decrease in radio and X-ray fluxes, then this would give strong support to a scenario where both SNe had undergone a similar kind of binary evolution before explosion.
Dichrorampha carpatalpina sp. n. (Lepidoptera, Tortricidae), a high mountain species of the Romanian Carpathians
Authors: Kovács Sándor , Kovács Zoltán
Published: April 2019

Dichroramphacarpatalpinasp. n., is described from the Southern Carpathians (Romania). It is closely related toD.inconspiqua(Danilevsky, 1948) andD.podoliensis(Toll, 1942). Adults, male and female genitalia, the habitat of the new species are described and figured and some details of the biology are given. The larva and its host-plant,Achilleaoxylobaschurii(Sch. Bip.) Heimerl, are illustrated. The species inhabits the north-facing slopes of the highest regions of the Carpathians. During their flight period from the beginning of July to the beginning of August the moths are on wing in the morning and only in sunny weather.
Lactobacillus casei CRL 431 improves endothelial and platelet functionality in a pneumococcal infection model
Authors: Haro C. , Medina M.
Published: April 2019

Streptococcus pneumoniae is able to activate coagulation and induce platelet aggregation, both of which are typical responses to systemic inflammation. The interactions between inflammation and coagulation and between soluble adhesion molecules and endothelial cells are important in the pathogenesis of an unbalanced haemostatic system. Therefore, an exaggerated and/or insufficiently controlled haemostatic activity may appreciably contribute to the severity of the disease. The aim of the present study was to evaluate the effect of the oral administration of Lactobacillus casei CRL 431 on platelet and endothelial activation mechanisms in a respiratory pneumococcal infection model in mice. S. pneumoniae induced an increase in platelet counts and enhanced the expression of P-selectin in control group, with higher endothelial activation in lung shown by the increase in von Willebrand factor (vWF) and vascular cell adhesion molecule 1 (VCAM-1) expression. Also, infection induced a decrease in CXCR-4 leukocytes, increased expression in annexinV and cell death at the pulmonary level and decreased antithrombin levels in bronchoalveolar lavage. In contrast, L. casei mice restored platelet counts, favoured faster P-selectin expression, lower vWF levels and VCAM-1 expression than control group. Also, L. casei induced higher levels of annexinV expression and lower cell death in the lung. Moreover, it was able to modulate antithrombin levels within the normal range, which would indicate lower coagulation activation and a protective effect locally exerted by L. casei. In this work, the ability of L. casei to favourably modulate platelet and endothelial functionality during a pulmonary infection with S. pneumoniae was demonstrated. Our findings offer a promising perspective for the use of this probiotic strain in the prevention of thrombotic complications associated with pneumococcal pneumonia, especially in at-risk patients. In addition, the use of L. casei would provide novel alternatives for the prevention and treatment of thrombosis associated with various diseases.
The CHROME Manifesto: integrating multimodal data into Cultural Heritage Resources
Authors: Cutugno Francesco , Dell’Orletta Felice , Poggi Isabella , Savy Renata , Sorgente Antonio
Published: April 2019

The CHROME Project aims at collecting a wide portfolio of digital resources oriented to technological application in Cultural Heritage (henceforth CH). The contributions for the realisation of such objective come from the efforts of computer scientists, psychologists, architects, and computational linguists, who constitute an interdisciplinary equipe. We are collecting and analyzing texts, spoken materials, architectural surveys, and human motion videos, attempting the integration of these data in a multidimensional platform based on multilevel annotation systems, game engines importing, and virtualization techniques. As case of study we choose to work on the magic travel along three Charterhouses located in Campania region: S. Martino in Naples, S. Lorenzo in Padula (Salerno) and S. Giacomo, in Capri.
De l’imperium à Rome et dans le monde romain
Authors: Benoist Stéphane
Published: April 2019

L’imperium, terme latin désignant en premier lieu le pouvoir à Rome, civil et militaire, puis la domination par la cité d’un vaste territoire et partant le régime politique à la tête duquel un imperator est placé, permet de revenir sur les approches proposées depuis le siècle des Lumières jusqu’au tournant des xxe et xxie siècles, tant à propos du destin de la cité-État devenue la tête d’un vaste territoire méditerranéen que de l’expression des pouvoirs qui s’exercent dans l’Vrbs et ce que l’on finira par nommer l’Imperium Romanum. Par étapes, le propos se veut philologique et historiographique, et insiste notamment sur les expressions du pouvoir, de la Res publica médiane au iiie siècle de notre ère, ainsi que sur les notions d’empire rendant compte des façons romaines d’envisager le rapport entre la cité (Vrbs) et le monde exploré puis contrôlé (l’Orbis terrarum).
Entre Latins et Grecs : émulation et rivalité autour de l’Empire, viie-xe siècle
Authors: Bougard François
Published: April 2019

Les relations entre Latins et Grecs autour de la question de l’Empire sont souvent vues à l’aune des débats des ixe et xe siècles. Pour mieux en apprécier la portée, il n’est pas inutile de repartir de la fin du vie siècle pour observer comment la progressive « occidentalisation » de la papauté a créé les conditions du conflit. L’universalisme chrétien importe autant sinon plus que la dimension romaine dans la notion d’Empire.
Temporal evaluation of soil chemical attributes after slash-and-burn agriculture in the Western Brazilian Amazon
Authors: Silva Neto Eduardo Carvalho da , Pereira Marcos Gervasio , Frade Júnior Elizio Ferreira , Silva Sandra Bezerra da , Carvalho Júnior João Andrade , Santos José Carlos Dos
Published: April 2019

In Amazonia, the main causes of deforestation are systems based on slash-and-burn agriculture. The objective of this work was to evaluate temporal changes in the soil chemical attributes after the vegetation has been slashed and burned in an area of native forest in the Western Amazon. For this study, four hectares of forest in Cruzeiro do Sul, State of Acre, Brazil, was slashed and burned. The soil in the study area was classified as Ultisol (Argissolo Amarelo Distrófico típico). Soil samples were collected over the course of one year, the first one being collected 16 hours after the burn and the others at 30, 60, 90, 150, 210, 270, and 360 days after the burn. The soil surface layers were more sensitive to fire action. Ashes from vegetation burn increased pH values, basic cations, and C values only in the first months, resulting in higher basal saturation values (V%). The practice of slash-and-burn after 12 months resulted in lower values of pH, Ca, Mg, K, and P and higher values of Al and H, as well as saturation by aluminum in the soil, indicating this practice contributes to the reduction of soil fertility.
How to write the discussion section of a scientific article
Authors: Vieira Rogerio Faria , Lima Renan Cardoso de , Mizubuti Eduardo Seiti Gomide
Published: April 2019

he Discussion is the hardest section of a scientific article to write, as cognitive skills must be used to properly contextualize the findings of a study. In this article, we guide scientific writers, particularly unexperienced ones, on how to structure a Discussion section based on an article by Docherty and Smith (1999). According to these authors, a discussion should be prepared by organizing information in the following order: (a) statement of principal findings; (b) strengths and weaknesses of the study; (c) strengths and weaknesses in relation to other studies, discussing particularly any differences in results; (d) meaning of the study: possible mechanisms and implications; and (e) unanswered questions and future research. Each component of this sequence is discussed in detail with examples drawn from the literature.
Numerical Thermal Analysis of a T Jump System Used for Studying Polymer Behaviour
Authors: Gomes Sara , Pascoal-Faria Paula , Mitchell Geoffrey R. , Gkourmpis Thomas , Youngs Tristan
Published: April 2019

The processing of polymers is highly complex. The study of their crystallisation assumes an important role and needs to be carefully detailed. Scattering experiments can be used to study polymer molecular organisation. However these procedures are still very multifaceted leading to the need for planning all the details in the experiments that are to be performed. This manuscript presents a finite element model developed to study the temperature variation of a T Jump System, which has been used for studying polymer behaviour with the NIMROD instrument at the ISIS Neutron and Muon Source, UK. Results show that the variation across the sample was 2oC at a maximum temperature of 70oC and 1oC at a maximum temperature of 50oC.
A Computer Simulation of the Nitinol Thermal Expansion under Fast Varying Working Conditions
Authors: Castelo Ferreira Pedro , Pascoal-Faria Paula , Carreira Pedro , Alves Nuno
Published: April 2019

We discuss the setup of a simulation on ANSYS to predict the thermal expansion of parts made of Nitinol. A simulation is justified for working conditions in which the part heating is not homogeneous originating a temperature gradient across the part section such that an analytical estimate for the part expansion cannot be calculated. We apply the simulation to the topological optimization of a square section geometry and a bullet geometry for water assisted injection molding. For the topological optimization we consider as parameter the wall thickness and consider both the cases of fast varying temperature and fast varying temperature and pressure.
A Computer Tool for 3D Shape Recovery of Fruits
Authors: Gaspar Miguel , Pascoal-Faria Paula , Amado Sandra , Alves Nuno
Published: April 2019

Characterizing a fruit’s mechanical behavior is an important step towards reducing economic losses due to bruising. Several 3D scanning technologies allow to obtain the external geometry of a fruit, but no easily accessible tools exist for the acquisition of the geometry of internal structures such as the core. We propose a low-cost destructive method for tomographic reconstruction of a fruit from scanned slices. A method for overcoming the difficulties in registering the different images is also presented.
I. Film: Using Electrospinning to Create Bioactive Films
Authors: Silva António Raimundo , Carreira Pedro , Santos Cyril , Reis Miguel , Mateus Artur
Published: April 2019

With increasing competition between companies, they are increasingly striving to produce higher quality products and to improve their production processes, and the food industry is no different. In order to preserve food for longer, this type of company has dedicated its attention to intelligent packaging, capable of preserving food for longer and of acting as a sensor of the state of food. To develop a film capable of fulfilling the new ambitions of the companies various manufacturing processes have been studied. This document gives an overview of the electrospinning process, capable of producing nanofibres of biological materials. This document aims to serve as a study base for the I.film project through the study of the process that will provide the polymer film with the necessary biological characteristics.
Biomechanical Outcomes Related with Gait in Children with Cerebral Palsy Using Ankle-Foot Orthotic - A Systematic Review
Authors: Gordo Jessica Jorge , Pascoal-Faria Paula , Mateus Artur , Morouço Pedro , Schiriati Verónica , Amado Sandra
Published: April 2019

Gait in children with cerebral palsy (CP) is often affected by motor impairments which limit the patient's ability to walk. To improve gait and reduce walking limitations, children with CP need to use ankle foot orthoses. An orthosis is an externally applied device that is designed and fitted to the body to achieve one or more of the following goals: a) Control biomechanical alignment. b) Correct or accommodate deformity, and 3) Protect and support an injury. This systematic review aims to describe research evidence supporting the use of ankle-foot orthoses to improve gait biomechanical outcomes among individuals with CP. Literature search was pursued from PubMed database. Studies were included if (1) they evaluated an outcome measure related with gait using ankle-foot orthotic (AFO) in children (2) considered children with a diagnosis of CP and have a (3) GMFCS classification of I, II or III. Papers were excluded if they evaluated (1) other population besides CP, (2) the use of orthoses other than AFOs and (3) gait analysis procedure was not presented. All the included studies have analyzed spatiotemporal parameters, the step length (m), stride length (m) and cadence (steps/minute) were the most frequently reported. Our findings showed that several studies have investigated the effects of AFOs, all of which have reported positive influences on at least one gait parameter, as well as positive changes in joint kinematics and kinetic in children with CP.
Electrical Stimulation Optimization in Bioreactors for Tissue Engineering Applications
Authors: Pascoal-Faria Paula , Castelo Ferreira Pedro , Datta Abhishek , Amado Sandra , Moura Carla , Alves Nuno
Published: April 2019

We review here the current research status on bioreactors for tissue engineering with cell electrical stimulation. Depending on the cell types, electrical stimulation has distinct objectives, in particular being employed both to mimic and enhance the endogenous electricity measured in the natural regeneration of living organisms as well as to mimic strain working conditions for contractible tissues (for instance muscle and cardiac tissues). Understanding the distinct parameters involved in electrical stimulation is crucial to optimize its application. The results presented in the literature and reviewed here reveal that the application of electrical stimulation can be essential for tissue engineering applications.
Rosin Based Composites for Additive Manufacturing
Authors: Sousa Dora , Biscaia Sara , Viana Tânia , Gaspar Miguel , Mahendra Vidhura , Mohan Saeed D. , Mateus Artur , Mitchell Geoffrey R.
Published: April 2019

Rosins are the non-volatile exudates of pine resins with hydrophobic characteristics that are widely used as a precursor for many industrial applications. In this paper we discuss the nature, process and its applications as a matrix for a composite material for additive manufacturing. The composite material has been tailored to chemical and mechanical properties with respect to their applications.
Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases
Authors: Boxberger Nina , Hecker Michael , Zettl Uwe K.
Published: April 2019

Inflammasomes are protein complexes that respond to a wide range of pathogens and cellular damage signals. Their activation prompts the caspase-1–mediated cleavage of the proinflammatory cytokines IL-1β and IL-18. Inflammasome dysregulation has been demonstrated to play a role in a range of diseases involving the adaptive immune system like multiple sclerosis, rheumatic diseases, and type 1 diabetes. Priming and activation of inflammasomes can be modulated by microRNAs (miRNAs), small noncoding RNAs that regulate gene expression posttranscriptionally. miRNAs, such as miR-223-3p, have been demonstrated to directly target the inflammasome components NLRP3, caspase-1, and caspase-8. Other miRNAs like miR-155-5p modulate TLR-, IL-1R–, TNFR-, and IFNAR-mediated signaling pathways upstream of the inflammasomes. In this study, we discuss how a more detailed elucidation of miRNA-driven inflammasome regulation helps in understanding the molecular processes underlying immune-mediated human diseases, holds potential for the identification of biomarkers and may offer novel targets for the development of future therapeutics.
Progressive Fatigue Damage Simulation in Laminated Composites Based on Explicit Finite Element Formulation
Authors: Nikishkov Yuri , Seon Guillaume , Makeev Andrew
Published: April 2019

Advanced polymeric composites are playing a major role in designing high-performance and lightweight vertical lift structures. However, uncertain residual strength and remaining useful life of the composite rotor and airframe structures due to complexity of failure mechanisms and susceptibility
to manufacturing irregularities, which may be precursors to structural damage, impose risks that cannot be mitigated exclusively by time-consuming and costly experimental iterations. Validated analysis techniques accelerating design, certification, and qualification of composite structures
are needed. Our team has been taking essential steps toward improving confidence in material qualification for laminated composites. The first step started with our reduced lamina test methods, short-beam shear, and small-plate twist based on digital image correlation measuring as a subset
the standard material properties and, in addition, key properties that cannot be currently measured using any standard test methods. The lamina properties provide essential material input data for laminate analysis. The laminate analysis was the second step increasing confidence in material
qualification. A known weakness of the existing progressive damage analysis methods is the lack of effective techniques to predict ultimate failure. The newly developed methodology relies on explicit finite element modeling and eliminates convergence issues in the ply-level progressive damage
analysis methods due to severe nonlinear discontinuities after propagation of damage beyond detectable size. This work shows results of applying this methodology to nanosilica-toughened IM7/PMT-F3GHT open-hole tension strength/fatigue, open-hole compression strength/fatigue, and bearing strength
multidirectional laminate configurations. The ability to predict progression of damage from initiation to ultimate strength and fatigue for advanced material systems including IM7/PMT-F3GHT carbon/epoxy reinforced by nanosilica has been demonstrated for the first time.
The role of protein-53 amyloid in determining the aggressiveness of basal cell carcinoma regulated by interleukin-6, myeloid cell leukemia-1 and basic fibroblast growth factor
Authors: Mawardi Prasetyadi , Kalim Handono , Kalim Kusworini Handono , Fitri Loeki Enggar , Mintarjo Karyono , Mudigdo Ambar , Oyong Oyong , Wasita Brian
Published: April 2019

Basal cell carcinoma (BCC) is a common malignant skin tumor that rarely metastasized, although it is often locally destructive and aggressive. The amyloid in BCC is resulted from degenerated epithelial cell through apoptosis caused by activation of p53. Interleukin-6, MCL-1 and bFGF are inflammatory mediators which have important role in angiogenesis. To prove that high expression of p53 amyloid is related to aggressiveness of BCC via the regulation of IL-6, MCL-1 and bFGF expression. Archived specimens from 51 cases diagnosed with Primary BCC. We performed immunohistochemical staining for IL-6, MCL-1, bFGF expression and p53 amyloid deposit. There was a significant difference in the expression of p53 (p = 0.04), amyloid deposits (p = 0.015), P53 amyloid deposits (p = 0.038), IL-6 (p = 0.040), MCL-1 (p = 0.032), bFGF (p = 0.044) in A BCC compared with NA BCC. There were a significant association between MCL-1 and bFGF (p = 0.07) and p53 amyloid with bFGF (p = 0.051). p53 amyloid, IL-6, MCL-1 and bFGF have an important role in BCC aggresivity.
Autologous non-cultured epidermal cell suspension combined with platelet rich fibrin for the treatment of stable vitiligo: A case series
Authors: Nareswari Adniana , Zulfikar Dendy , Julianto Indah , Widhiati Suci
Published: April 2019

Non-cultured epidermal cell suspension (NCECS) is a relatively new cellular grafting technique for vitiligo. Platelet rich fibrin (PRF) is a platelet and immune concentrate gather on a single fibrin membrane which can be used in conjunction with grafts and has several advantages, such as promoting wound healing, haemostasis, and give better handling properties to graft materials. This study was conducted to determine the efficacy of NCECS combined with PRF in patients with stable vitiligo. Seven patients with stable vitiligo which not responding to topical and phototherapy for more than 12 months were included in the study. The melanocytes were harvested as an autologous melanocyte rich suspension from a donor skin. The non cultured melanocyte transplanted to recipient area that had been superficially dermabraded and smeared with PRF gel. Of all 7 patients, 1 patients showed excellent pigmentation (90-100%), 2 had good repigmentation (60-89%), 1 had fair repigmentation (25-59%) and 3 patients had a poor response (0-24%). The procedure is safe and promising surgical modality for stable vitiligo.
Comparison amount of microphthalmia-associated transcription factor in vitiligo before and after narrowband-ultraviolet B therapy
Authors: Listiawan M. Yulianto , Astari Linda , Wardhani Putri Hendria
Published: April 2019

Vitiligo is the most commonly seen depigmentation disease with clinical manifestations of milk colored white macules, complex pathogenesis that is not well understood so that evolution of the disease is unpredictable and therapeutic outcomes are often unsatisfactory. Until now narrowband-ultraviolet B (NB-UVB) is considered the most effective and safe treatment for vitiligo. Therapy evaluation by looking at melanocytes function that can be seen with microphthalmia-associated transcription factor (MITF) immunohisto - chemistry will become more objective and accurate. This is a comparative analytic experimental study using pre-post test method comparing MITF in vitiligo patients before and after receiving NB-UVB conducted at Dr. Soetomo general hospital Surabaya, 12 vitiligo samples treated only with NB-UVB twice a week until 8 times therapies. The first exposure dose was 200 mJ and gradually increased 20% every therapy. Biopsy was performed before and after therapies and then MITF was compared. There was a significant difference between the amount of MITF in vitiligo before NB-UVB and after NB-UVB therapy stastistically, p=<0.001 (p=0.05). MITF is useful for indicators of treatment success.
Polymerase chain reaction chlamydia trachomatis examination in nonspecific genital infection patients
Authors: Habibie Dian Pertiwi , Murtiastutik Dwi , Rahmadewi R.
Published: April 2019

Introduction: Nonspecific genital infection (NSGI) is an inflammation of urethra, rectum, or cervix that caused by nonspecific bacteria. Chlamydia trachomatis is known as the most causal organism of NSGI, usually mild (mucopurulent discharge) or asymptomatic, and if untreated it can cause serious complication such as pelvic inflammatory disease that leads to infertility in women. The diagnosis of Chlamydia trachomatis needs an advanced method, such as polymerase chain reaction (PCR). PCR has high sensitivity and specificity, and endocervical swab is specimen of choice that also has high sensitivity and specificity to diagnose Chlamydia trachomatis. Method: This research aims to evaluate if Chlamydia trachomatis is the most causal organism of NSGI by PCR Chlamydia trachomatis using 201bp primers. Results: Eighteen NSGI married patients who came to outpatient clinic were evaluated from endocervical swab. The result demonstrated that 16,67% from eighteen NSGI patient positive Chlamydia trachomatis. Conclusion: The low incidence of Chlamydia trachomatis in low risk population such in this study need further study, the cause of NSGI needs to be known certainly so the exact treatment can be given.
The Correlation of Ig M Anti PGL-1 antibody between blood veins and dryed capillary blood on filter papers in household contact of leprosy patient
Authors: Prakoeswa Anisha Calista , Rumondor Bayu Bijaksana , Trianita Meva Nareza , Iswahyudi I. , Rosida Fatma , Astari Linda , Listiawan M. Yulianto , Agusni Indropo , Izumi Shinzo , Alinda Medhi Denisa
Published: April 2019

Delays of leprosy detection and treatment can lead to disability and potential transmission. Serologic examination has the advantage in detecting Subclinical Leprosy. The procedure of serologic test, which is one of its main limitation, could be simplified by the use filter paper. This study aims to assess the effectiveness of the use of capillary blood dropped on filter paper as a substitute for venous blood in household contact of leprosy patients. Seventeen samples of capillary blood dried on filter paper and venous blood samples from the same individual were examined by ELISA method to determine the levels of IgM anti-Phenolic glycolipid-1 (PGL-1). The mean of anti- PGL-1 IgM levels of filter paper samples 163.31±126.16; whereas the mean of levels from venous samples was 473.16±411.26. There was significant difference and correlation between these two groups. Samples on filter paper in household contact can be used to determine the level of anti-PGL-1 IgM in serum by converting on the regression basis. Further study is required to evaluate the potency of filter paper methods to conduct large-scale serological screening.
Staphylococcus aureus colonization on antecubital non-exacerbated atopic dermatitis patient compared to healthy children
Authors: Khamidah Nur , Ervianti Evy , Sukanto Hari
Published: April 2019

Atopic dermatitis is chronic pruritic inflammatory skin disease affects one third of children in the world, and the highest number of child`s skin problems in Indonesia. The complex role of the skin microbiome in the pathogenesis of atopic dermatitis is being elucidated. Interaction between skin barrier defects, and immunological factors can change the skin microbiome, and increased Staphylococcus aureus colonization. The aim of this study was to compare the colony of Staphylococcus aureus from antecubital fossa of non-exacerbated atopic dermatitis children to healthy children without history of atopic dermatitis. A comparative observational analytic with cross sectional design, examined antecubital swab culture from 17 non-exacerbated atopic dermatitis patients and 17 controls to investigate the presence of Staphylococcus aureus and density of the colonization. Staphylococcus aureus skin colonization was seen in 5 patients (29.41%) in non-exacerbated atopic dermatitis patients but none in control group (statistically significant with p=0.044), relative risk 2.417. All of positive colonization revealed moderate and heavy bacterial growth (104->105 cfu/cm2). This finding supports previous study that atopic dermatitis prone to colonized with Staphylococcus aureus.
Xeroderma pigmentosum with ocular involvement and squamous cell carcinoma: A case report
Authors: Saputri Bernadya Yogatri Anjuwita , Zulkarnain Iskandar
Published: April 2019

Xeroderma Pigmentosum is a rare, autosomal recessive genetic disorder, characterized by defective DNA repair leading to clinical and cellular hypersensitivity to ultraviolet radiation and carcinogenic agents. Patients with xeroderma pigmentosum often have cutaneous and ocular sun sensitivity and freckle-like skin pigmentation. Skin changes are the most important symptoms and they manifest as erythema, painful blisters and ulceration. The last level of skin changes transformation are malignant neoplasms, particularly squamous cell carcinoma. There is a great involvement of many parts of the body, especially the head and neck. This paper describes a case of xeroderma pigmentosum with advanced cutaneous squamous cell carcinoma and ocular lesions in a nine-year-old boy. The extensive ultraviolet radiation-induced skin and eye damage are evidence of a failure to use sun-protection and a lack of appropriate medical care from childhood.
A split-face of dermaroller and intradermal injection with the autologous platelet rich fibrin lysate in the treatment of exogenous ocronosis: A case series
Authors: Mochtar Moerbono , Ilona Sri Esa , Zulfikar Dendy , Murastami Ammarilis , Widhiati Suci
Published: April 2019

Exogenous ochronosis (EO) is a rare, cosmetically disfiguring condition, resulting from the long term use of topical hydroquinone in treatment of melasma. The studies about it are small and many of the treatments have mixed result. Autologous human platelet rich fibrin (PRF-L) is contains platelet that are purpose to release numerous growth factor that valuable in numerous dermatologic application.Platelet rich fibrin lysate used for EO has not been reported. We presented three cases with EO treated with split-face of the PRF-L applied right before dermaroller on right face and intradermal injection on the left for 8 weeks.The treatment re-apply every 2 weeks. The improvement was measuring by 10-point grading scale and dermoscopic examination, including five-point grading scale to assessment of patient satisfaction. All of three patients demonstrated significant improvementand very satisfied in 4th week of treatment. This result suggests that PRF-L can be used as of one modality for EO treatment.
Establishing the diagnosis neurofibromatosis type 1: A rare case
Authors: Devy Dyatiara , Damayanti D.
Published: April 2019

Neurofibromatosis type 1 (NF1) or Von Recklinghausen's disease is a dominantly inherited genetic, multisystem disorder. Individuals with neurofibromatosis type 1 are prone to develop benign and malignant tumors of the CNS and peripheral nervous system, in addition to malignant diseases affecting other parts of the body. About 50% of individuals with neurofibromatosis type 1 have no family history of the disease and the disease is due to de novo (spontaneous) mutations. Early diagnosis is challenging because of its extremely variable characteristics. Some individuals may be mildly affected showing minimal signs, whereas others are severely afflicted. Individuals with NF-1 are best cared for within a multidisciplinary clinic, which has access to a wide range of subspecialists. The dermatologist has a role not only in the diagnosis of NF1 and differentiating it from other similar disorders, but also in the recognition of rare associated skin manifestations.
Vaginal length after a laparoscopic sacropexy
Authors: Drusany Starič Kristina , Lukanović Adolf , Barbič Matija , Blaganje Mija , Cvijić Adriana , But Igor
Published: April 2019

Vaginal shortening after surgical treatment of pelvic organ prolapse is associated with dyspareunia, which negatively affects women’s sexual life as well as their psychosocial well-being. The aim of the study is to determine the vaginal length in women with high-grade pelvic organ prolapse treated with laparoscopic sacropexy. In the prospective study we included 22 women with high-grade prolapse of the uterus or vagina that were treated. They underwent a gynaecological examination with a measurement of the vaginal length, as well as the evaluation of the degree of prolapse prior to the procedure (laparoscopic sacropexy). The second measurement and evaluation of the vaginal length during the follow-up examination between 6 to 12 weeks after surgery was done. The control group included 23 healthy women, without genital prolapse. There was no statistically significant difference in the mean vaginal length before and after surgery in the group of treated women.
Subjective experiences of employment equity in South African organisations
Authors: Oosthuizen Rudolf M. , Tonelli Louise , Mayer Claude-Hélène
Published: April 2019

Orientation: This article explores employees’ subjective experiences of employment equity (EE) within South African organisational contexts, adding diverse and in-depth insights to the post-apartheid EE discourse.Research purpose: The purpose is to hear the voices of employees of different social-cultural, racial and gender backgrounds on the experiences of EE in contemporary South African organisations.Motivation for the study: Research suggests that South African organisations are pressurised to redress past racial inequality. Understanding employees’ subjective experiences of EE adds value to the debate and provides the reader with an in-depth contemporary image of EE in post-apartheid South African organisations.Research approach/design and method: A hermeneutic phenomenological approach, within the qualitative interpretive paradigm, yielded in-depth, rich and detailed descriptions of employees’ experiences of EE in both the private and public sectors of the South African workplace.Main findings: Findings show five themes that are associated with experiences of EE within South African organisations. This study highlights differences of experiences regarding EE plans and processes based on racial background, gender and age, as well as on historical socio-cultural and racial classifications of being a member of advantaged and disadvantaged groups. The following findings are highlighted: the insight into the experiences of EE from the perspectives of the ‘born-frees’ (the differences in experiences of different age groups of employees) and the experienced discrimination of black male and female employees regarding race and the experiences of gender-based discrimination being described by black and white male employees.Practical/managerial implications: Findings show the focus of experiences of EE, the conflicting issues and what South African organisations need to focus on in terms of human resources management (HRM) and the development of employee relations across racial and gender divides. It shows which topics need to be addressed in employee development and training programmes to manage diversity constructively and effectively.Contribution/value-add: The findings can be used by human resources managers to: (1) monitor the progress towards EE competently and vigorously, (2) create awareness and communication within individuals, organisations and society regarding EE, (3) create best practices in order to benefit from EE (members of all racial, gender, cultural groups), (4) create a discourse on humanistic and reflexive HRM, and(5) implement consulting, training and development programmes in organisations that are strategically, sustainably and long-term orientated.
Air pockets and secondary habits in ice from lateral-type growth
Authors: Nelson Jon , Swanson Brian
Published: April 2019

Abstract. Often overlooked in studies of ice growth is how the crystal faces grow laterally. This paper explores the implications of such lateral-type growth and how it may explain air pockets and other secondary features of vapor-grown ice in air. For example, using a new crystal-growth chamber, we observed air pockets forming at crystal corners when a sublimated crystal is regrown. This and other observations support the idea that the lateral spreading of a face, and its (in some cases) extension as a thin overhang over the adjoining region, is driven by a flux of surface-mobile admolecules across the face to the lateral-growth front. Inspired by recent work on this topic by Prof. A. Yamashita of Osaka Kyoiku University, we call this flux adjoining surface transport (AST) and the extension overgrowth protruding growth, then apply the concepts to observed ice and snow crystals, including some from a cloud chamber and others from our experiments. We also suggest that such lateral-type growth may explain other air pockets, droxtal centers in dendrites, hollow terracing and banding, multiple-capped columns, scrolls, trigonals, and sheath clusters. For dendrites and sheaths, AST may increase their maximum dimensions and round their tips.
Optical flow models as an open benchmark for radar-based precipitation nowcasting (rainymotion v0.1)
Authors: Ayzel Georgy , Heistermann Maik , Winterrath Tanja
Published: April 2019

Abstract. Quantitative precipitation nowcasting (QPN) has become an
essential technique in various application contexts, such as early warning or
urban sewage control. A common heuristic prediction approach is to track the
motion of precipitation features from a sequence of weather radar images and
then to displace the precipitation field to the imminent future (minutes to
hours) based on that motion, assuming that the intensity of the features
remains constant (“Lagrangian persistence”). In that context, “optical
flow” has become one of the most popular tracking techniques. Yet the
present landscape of computational QPN models still struggles with producing
open software implementations. Focusing on this gap, we have developed and
extensively benchmarked a stack of models based on different optical flow
algorithms for the tracking step and a set of parsimonious extrapolation
procedures based on image warping and advection. We demonstrate that these
models provide skillful predictions comparable with or even superior to
state-of-the-art operational software. Our software library (“rainymotion”)
for precipitation nowcasting is written in the Python programming language
and openly available at GitHub (https://github.com/hydrogo/rainymotion,
Ayzel et al., 2019). That way,
the library may serve as a tool for providing fast, free, and transparent
solutions that could serve as a benchmark for further model development and
hypothesis testing – a benchmark that is far more advanced than the
conventional benchmark of Eulerian persistence commonly used in QPN
verification experiments.
Determinants of thermal regime influence of small dams
Authors: Chandesris André , Van Looy Kris , Souchon Yves
Published: April 2019

Abstract. The purpose of this study was to quantify the downstream impacts of different types of small dams on summer water temperature in lowland streams. We examined: (i) temperature regime upstream and downstream dams of different structural characteristics; (ii) relationships between stream temperature anomalies and climatic variables, watershed area, dam height, impoundment length and surface and residence time; (iii) the more significant variables explaining the different thermal behaviours, in order to account for dam diversity and functioning in future regional stream temperature models. Water temperature loggers were installed upstream and downstream 11 dams in the Bresse Region (France) and monitored at 30 min intervals during summer period (June to September), from 2009 to 2016 depending on the sites (2 sites were monitored during 2 summers, others only 1 summer, resulting in 13 time-series), with the opportunity to compare cold and hot summers. The small dams altered the downstream thermal regime for 23 % of the time-series with a > 1 °C elevation of the maximum daily temperature; for 77 % the range was in between −1 °C and +1 °C. The mean increase of the minimum daily temperature was 1 °C, with 85 % of the time-series showing an increase > 0.5 °C. The sites are grouped in three main types with specific responses of different temperature variables (maximum daily temperature (T max), minimum daily temperature (T min) and daily temperature amplitude). Two main types of impact were identified: an increase in the daily minimum temperatures associated with stability and even a slight reduction of the daily maximum temperatures for impoundments of low volume (residence time shorter than 0.7 day and an impoundment surface area smaller than 35 000 m2); and an increase of the daily minimum and maximum temperatures in the same orders of magnitude when the surface area of the impoundment is larger than 35 000 m2 and the residence time is longer than 0.7 day. This increase can reach 2.4 °C at certain structures and could impact the structure of aquatic communities and the functioning of the aquatic ecosystem. These determinants are candidate to generalize results, but this would necessitate the gathering of more precise information than the current dam descriptors in public databases.
Modelling the future evolution of glaciers in the European Alps under the EURO-CORDEX RCM ensemble
Authors: Zekollari Harry , Huss Matthias , Farinotti Daniel
Published: April 2019

Abstract. Glaciers in the European Alps play an important role in
the hydrological cycle, act as a source for hydroelectricity and have a
large touristic importance. The future evolution of these glaciers is driven
by surface mass balance and ice flow processes, of which the latter is to
date not included explicitly in regional glacier projections for the Alps.
Here, we model the future evolution of glaciers in the European Alps with
GloGEMflow, an extended version of the Global Glacier Evolution Model (GloGEM),
in which both surface mass balance and ice flow are explicitly
accounted for. The mass balance model is calibrated with glacier-specific
geodetic mass balances and forced with high-resolution regional climate
model (RCM) simulations from the EURO-CORDEX ensemble. The evolution of the
total glacier volume in the coming decades is relatively similar under the
various representative concentrations pathways (RCP2.6, 4.5 and 8.5), with
volume losses of about 47 %–52 % in 2050 with respect to 2017. We find that
under RCP2.6, the ice loss in the second part of the 21st century is
relatively limited and that about one-third (36.8 % ± 11.1 %,
multi-model mean ±1σ) of the present-day (2017) ice volume
will still be present in 2100. Under a strong warming (RCP8.5) the future
evolution of the glaciers is dictated by a substantial increase in surface
melt, and glaciers are projected to largely disappear by 2100 (94.4±4.4 %
volume loss vs. 2017). For a given RCP, differences in future
changes are mainly determined by the driving global climate model (GCM),
rather than by the RCM, and these differences are larger than those arising
from various model parameters (e.g. flow parameters and cross-section
parameterisation). We find that under a limited warming, the inclusion of
ice dynamics reduces the projected mass loss and that this effect increases
with the glacier elevation range, implying that the inclusion of ice
dynamics is likely to be important for global glacier evolution projections.