bluuebunny/crossref_metadata_2025 huggingface dataset:
Salivary cortisol levels and stress in adults with profound intellectual and multiple disabilities participating in the Structured Water Dance Intervention: a randomised controlled crossover trial
Authors: Lundqvist Lars-Olov , Matérne Marie , Frank Andre , Mörelius Evalotte , Duberg Anna
Published: October 2022

The Structured Water Dance Intervention (SWAN) is a dance-oriented aquatic group activity directed to give opportunities for the joy of movement, relaxation, and reduced stress. This study aimed to evaluate the effects of SWAN on salivary cortisol and stress in adults with profound intellectual and multiple disabilities (PIMD). A total of 34 adults with PIMD at four habilitation centres in Sweden completed the SWAN intervention. The intervention was administered for 40 min once a week during a 12-week period. Saliva cortisol was collected in the morning and evening at baseline one week before the intervention, thrice during the intervention period, and one week after the intervention. Moreover, in connection with the SWAN sessions, the participants’ level of stress was also assessed by the accompanying assistants. The results showed that salivary cortisol and participants stress decreased significantly, directly after the SWAN sessions compared with measures directly before sessions. The study demonstrates that adults with PIMD have diurnal salivary cortisol patterns consistent with those observed in adults without disability and that the SWAN reduces salivary cortisol levels and stress in people with PIMD; this justifies that SWAN could be considered in the choice of interventions to reduce stress in adults with PIMD.

Trial registration: This study is registered 09/04/2019 on ClinicalTrials.gov (ID: NCT03908801).
Magnetic properties of FeGa/Kapton for flexible electronics
Authors: Pradhan Gajanan , Celegato Federica , Barrera Gabriele , Olivetti Elena Sonia , Coisson Marco , Hajduček Jan , Arregi Jon Ander , Čelko Ladislav , Uhlíř Vojtěch , Rizzi Paola , Tiberto Paola
Published: October 2022

Flexible materials have brought up a new era of application-based research in stretchable electronics and wearable devices in the last decade. Tuning of magnetic properties by changing the curvature of devices has significant impact in the new generation of sensor-based technologies. In this work, magnetostrictive FeGa thin films have been deposited on a flexible Kapton sheet to exploit the magneto-elastic coupling effect and modify the magnetic properties of the sample. The FeGa alloy has high magnetostriction constant and high tensile strength making its properties susceptible to external stress. Tensile or compressive strain generated by the convex or concave states influence the uniaxial magnetic anisotropy of the system. Low temperature measurements show a hard magnetic behavior and the presence of exchange-bias effect after field cooling to 2 K. The results obtained in this study prove essential for the development of flexible electronics.
Genome-wide association study reveals distinct genetic associations related to leaf hair density in two lineages of wheat-wild relative Aegilops tauschii
Authors: Mahjoob Mazin Mahjoob Mohamed , Kamal Nasrein Mohamed , Gorafi Yasir Serag Alnor , Tsujimoto Hisashi
Published: October 2022

Wild relatives of modern crops represent a promising source of genetic variation that can be mined for adaptations to climate change. Aegilops tauschii, the D-sub-genome progenitor of bread wheat (Triticum aestivum), constitutes a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Leaf hairiness plays an essential biological role in plant defense against biotic and abiotic stress. We investigated the natural variation in leaf hair density (LHD) among 293 Ae. tauschii accessions. Genome-wide association studies were performed for LHD with 2430 and 3880 DArTseq derived single nucleotide polymorphism (SNP) markers in two lineages of this species, TauL1 and TauL2, respectively. In TauL1, three marker-trait associations (MTAs) were located on chromosome 2D, whereas in TauL2, eight MTAs were identified, two associations were localized on each of the chromosomes 2D, 3D, 5D, and 7D. The markers explained phenotypic variation (R2) from 9 to 13% in TauL1 and 11 to 36% in TauL2. The QTLs identified in chromosomes 2D and 5D might be novel. Our results revealed more rapid and independent evolution of LHD in TauL2 compared to TauL1. The majority of LHD candidate genes identified are associated with biotic and abiotic stress responses. This study highlights the significance of intraspecific diversity of Ae. tauschii to enhance cultivated wheat germplasm.
3D multi-physics uncertainty quantification using physics-based machine learning
Authors: Degen Denise , Cacace Mauro , Wellmann Florian
Published: October 2022

Quantitative predictions of the physical state of the Earth’s subsurface are routinely based on numerical solutions of complex coupled partial differential equations together with estimates of the uncertainties in the material parameters. The resulting high-dimensional problems are computationally prohibitive even for state-of-the-art solver solutions. In this study, we introduce a hybrid physics-based machine learning technique, the non-intrusive reduced basis method, to construct reliable, scalable, and interpretable surrogate models. Our approach, to combine physical process models with data-driven machine learning techniques, allows us to overcome limitations specific to each individual component, and it enables us to carry out probabilistic analyses, such as global sensitivity studies and uncertainty quantification for real-case non-linearly coupled physical problems. It additionally provides orders of magnitude computational gain, while maintaining an accuracy higher than measurement errors. Although in this study we use a thermo-hydro-mechanical reservoir application to illustrate these features, all the theory described is equally valid and applicable to a wider range of geoscientific applications.
Alignment-invariant signal reality reconstruction in hyperspectral imaging using a deep convolutional neural network architecture
Authors: Mousavi M. S. Shayan , Pofelski Alexandre , Teimoori Hassan , Botton Gianluigi A.
Published: October 2022

The energy resolution in hyperspectral imaging techniques has always been an important matter in data interpretation. In many cases, spectral information is distorted by elements such as instruments’ broad optical transfer function, and electronic high frequency noises. In the past decades, advances in artificial intelligence methods have provided robust tools to better study sophisticated system artifacts in spectral data and take steps towards removing these artifacts from the experimentally obtained data. This study evaluates the capability of a recently developed deep convolutional neural network script, EELSpecNet, in restoring the reality of a spectral data. The particular strength of the deep neural networks is to remove multiple instrumental artifacts such as random energy jitters of the source, signal convolution by the optical transfer function and high frequency noise at once using a single training data set. Here, EELSpecNet performance in reducing noise, and restoring the original reality of the spectra is evaluated for near zero-loss electron energy loss spectroscopy signals in Scanning Transmission Electron Microscopy. EELSpecNet demonstrates to be more efficient and more robust than the currently widely used Bayesian statistical method, even in harsh conditions (e.g. high signal broadening, intense high frequency noise).
Epidemiology of acute gastroenteritis in France from November 2019–August 2021, in light of reported adherence to COVID-19 barrier measures
Authors: Nisavanh Athinna , Horrigue Imene , Debin Marion , Turbelin Clément , Kengne-Kuetche Charly , Nassany Oriane , Ambert-Balay Katia , Jourdan-Da Silva Nathalie , Pontais Isabelle , de Valk Henriette , Jones Gabrielle
Published: October 2022

Since the start of the COVID-19 pandemic, French health authorities have encouraged barrier measures and implemented three lockdowns to slow SARS-CoV-2 transmission. We aimed to examine the impact of these measures on the epidemiology of acute gastroenteritis (AGE) in France, from November 2019 to August 2021. We describe trends in AGE indicators from syndromic surveillance and a sentinel surveillance network. Additionally, we describe reported AGE illness data from a community based cohort, and frequencies of adherence to COVID-19 barrier measures from repeated quantitative surveys. From week 7 in 2020, all AGE indicators reached the lowest levels observed since the last decade. During the first lockdown, the median incidence rate reported by the sentinel network was 32 per 100,000 inhabitants, 1.9 times lower than the minimum registered during the 2010–2019 period. Low activity persisted until April 2021. Reported illness from the community cohort mirrored these trends. Adherence to COVID-19 barrier measures was highest during the first lockdown, coinciding with the steep decrease in AGE incidence. Among children under 5 years, AGE incidence increased after the third lockdown in June and July 2021, but remained lower than previous winter-season peaks. Our study indicates that a reduction in adherence to COVID-19 barrier measures, and the end of the lockdowns, coincided with an increase in AGE incidence, particularly among young children. We therefore strongly recommend maintaining adherence to barrier measures in order to in order to limit the transmission of AGE related pathogens.
Peripheral T cell cytotoxicity predicts the efficacy of anti-PD-1 therapy for advanced non-small cell lung cancer patients
Authors: Iwahori Kota , Uenami Takeshi , Yano Yukihiro , Ueda Toshihiko , Tone Mari , Naito Yujiro , Suga Yasuhiko , Fukushima Kiyoharu , Shiroyama Takayuki , Miyake Kotaro , Koyama Shohei , Hirata Haruhiko , Nagatomo Izumi , Kida Hiroshi , Mori Masahide , Takeda Yoshito , Kumanogoh Atsushi , Wada Hisashi
Published: October 2022

Anti-programmed cell death-1 (PD-1) therapy exerts beneficial effects in a limited population of cancer patients. Therefore, more accurate diagnostics to predict the efficacy of anti-PD-1 therapy are desired. The present study investigated whether peripheral T cell cytotoxicity predicts the efficacy of anti-PD-1 therapy for advanced non-small cell lung cancer (NSCLC) patients. Advanced NSCLC patients treated with anti-PD-1 monotherapy (nivolumab or pembrolizumab) were consecutively enrolled in the present study. Peripheral blood samples were subjected to an analysis of peripheral T cell cytotoxicity and flow cytometry prior to the initiation of anti-PD-1 therapy. Peripheral T cell cytotoxicity was assessed using bispecific T-cell engager (BiTE) technology. We found that progression-free survival was significantly longer in patients with high peripheral T cell cytotoxicity (p = 0.0094). In the multivariate analysis, treatment line and peripheral T cell cytotoxicity were independent prognostic factors for progression-free survival. The analysis of T cell profiles revealed that peripheral T cell cytotoxicity correlated with the ratio of the effector memory population in CD4+ or CD8+ T cells. Furthermore, the results of flow cytometry showed that the peripheral CD45RA+CD25+/CD4+ T cell ratio was higher in patients with than in those without severe adverse events (p = 0.0076). These results indicated that the peripheral T cell cytotoxicity predicted the efficacy of anti-PD-1 therapy for advanced NSCLC patients.
Classification of breast cancer histology images using MSMV-PFENet
Authors: Liu Linxian , Feng Wenxiang , Chen Cheng , Liu Manhua , Qu Yuan , Yang Jiamiao
Published: October 2022

Deep learning has been used extensively in histopathological image classification, but people in this field are still exploring new neural network architectures for more effective and efficient cancer diagnosis. Here, we propose multi-scale, multi-view progressive feature encoding network (MSMV-PFENet) for effective classification. With respect to the density of cell nuclei, we selected the regions potentially related to carcinogenesis at multiple scales from each view. The progressive feature encoding network then extracted the global and local features from these regions. A bidirectional long short-term memory analyzed the encoding vectors to get a category score, and finally the majority voting method integrated different views to classify the histopathological images. We tested our method on the breast cancer histology dataset from the ICIAR 2018 grand challenge. The proposed MSMV-PFENet achieved 93.0$$\%$$
%
and 94.8$$\%$$
%
accuracies at the patch and image levels, respectively. This method can potentially benefit the clinical cancer diagnosis.
Early onset of sleep/wake disturbances in a progressive macaque model of Parkinson’s disease
Authors: Davin Aurélie , Chabardès Stéphan , Belaid Hayat , Fagret Daniel , Djaileb Loic , Dauvilliers Yves , David Olivier , Torres-Martinez Napoléon , Piallat Brigitte
Published: October 2022

Parkinsonian patients often experience sleep/wake disturbances, which may appear at an early stage of the disease; however, these disturbances have not been fully described. To better understand the evolution of these disturbances with respect to disease progression, we aimed to characterize these clinical signs in a progressive nonhuman primate model of Parkinson's disease. Three adult macaques (Macaca fascicularis) were equipped with a polysomnographic telemetry system allowing the characterization of sleep/wake behavior via long-term neurophysiological recordings and underwent a modified multiple sleep latency test. Experiments were first performed in a healthy state and then during the progressive induction of a parkinsonian syndrome by intramuscular injections of low doses of MPTP. We observed an early onset of significant sleep/wake disturbances (i.e., before the appearance of motor symptoms). These disturbances resulted in (i) a disorganization of nighttime sleep with reduced deep sleep quality and (ii) an excessive daytime sleepiness characterized by sleep episodes occurring more rapidly in the morning and spreading through the middle of the day. The present study suggests that nighttime and daytime sleep/wake disturbances may appear early in the disease and should be considered in the development of biomarkers in further studies.
Fractional anisotropy and peripheral cytokine concentrations in outpatients with depressive episode: a diffusion tensor imaging observational study
Authors: Sammer Gebhard , Neumann Elena , Blecker Carlo , Pedraz-Petrozzi Bruno
Published: October 2022

Over the past few years, evidence of a positive relationship between inflammation and depression has grown steadily. The aim of the current study was to investigate whether such depression-related inflammation could also be associated with altered microstructural changes in the white matter. FA and serum cytokines (IL-1β, IL-6, TNF-α, and IFN-γ) were measured in 25 patients with depression (DE) and 24 healthy controls (HC). Diffusion tensor imaging was performed. Fractional anisotropy (FA) was calculated using the FSL pipeline for Tract-Based Spatial Statistics (TBSS). Both voxelwise and mean whole-brain FA were analyzed using general linear models (GLM). Higher concentrations of IL-1β were associated with lower whole-brain fractional anisotropy, particularly in people with depression (ρ = − 0.67; p < 0.001). TNF-α shared some variance with IL-1β and also showed a negative relationship between TNF-α concentrations and FA in depression (F1,46 = 11.13, p = 0.002, η2p = 0.21). In detail, the voxelwise analysis showed that the regression slopes of IL-1β on FA were more negative in the DE group than in the HC group, mainly in the corpus callosum (cluster statistics: genu corpus callosum, p = 0.022; splenium of corpus callosum, p = 0.047). Similar effects were not found for the other remaining cytokines. This study clearly demonstrated an association between peripherally measured IL-1β and white matter integrity in depression as assessed by DTI. The results suggest that microstructural changes in the corpus callosum are associated with increased peripheral IL-1β concentrations in depression.
Peripheral mononuclear cells composition in platelet-rich fibrin in canines with chronic conditions
Authors: Jasineviciute Indre , Grigas Juozas , Ziukaite Gintare , Pautienius Arnoldas , Razukevicius Dainius , Zymantiene Judita , Stankevicius Arunas
Published: October 2022

Platelet-rich fibrin (PRF) is a hot research topic because of its regenerative effect in humans. However, data reporting about its application in companion animals is lacking. The study aimed to supplement currently available data on PRF cell composition in canine patients by isolating peripheral blood mononuclear cells (PBMC), namely T cells, matured B cells, monocytes and macrophages, and adapting current protocols of cell flow cytometry for PRF analysis. The canine patient population was divided into three subgroups: animals with periodontitis only, animals with neoplasia and periodontitis, and healthy controls. Individual clinical parameters of the patients and evaluation of the wound healing quality were included in the research. In the present study, canine PRF cell composition was analyzed for the first-time using cell flow cytometry protocol. A higher proportion of PBMC cells related to wound healing (CD3+, CD3+ CD4+ CD8−, CD14+) were found in the PRF of control, periodontitis and neoplasia groups compared to the respective blood samples, which implies a positive outcome associated with clinical PRF usage in canine patients. Proportions of monocytes and macrophages were higher in PRF samples compared to the blood of healthy patients and periodontitis-affected patients. However, inflammatory and neoplastic processes do not affect the distribution of PBMC.
Meta-analysis of microbiome association networks reveal patterns of dysbiosis in diseased microbiomes
Authors: Lam Tony J. , Ye Yuzhen
Published: October 2022

The human gut microbiome is composed of a diverse and dynamic population of microbial species which play key roles in modulating host health and physiology. While individual microbial species have been found to be associated with certain disease states, increasing evidence suggests that higher-order microbial interactions may have an equal or greater contribution to host fitness. To better understand microbial community dynamics, we utilize networks to study interactions through a meta-analysis of microbial association networks between healthy and disease gut microbiomes. Taking advantage of the large number of metagenomes derived from healthy individuals and patients with various diseases, together with recent advances in network inference that can deal with sparse compositional data, we inferred microbial association networks based on co-occurrence of gut microbial species and made the networks publicly available as a resource (GitHub repository named GutNet). Through our meta-analysis of inferred networks, we were able to identify network-associated features that help stratify between healthy and disease states such as the differentiation of various bacterial phyla and enrichment of Proteobacteria interactions in diseased networks. Additionally, our findings show that the contributions of taxa in microbial associations are disproportionate to their abundances and that rarer taxa of microbial species play an integral part in shaping dynamics of microbial community interactions. Network-based meta-analysis revealed valuable insights into microbial community dynamics between healthy and disease phenotypes. We anticipate that the healthy and diseased microbiome association networks we inferred will become an important resource for human-related microbiome research.
Combination venetoclax and selinexor effective in relapsed refractory multiple myeloma with translocation t(11;14)
Authors: Nguyen Nina , Chaudhry Sana , Totiger Tulasigeri M. , Diaz Robert , Roberts Evan , Montoya Skye , Pardo Gabriel , Pardo Alejandro , Afaghani Jumana , Affer Maurizio , Jahn Jacob , Bradley Terrence , Maura Francesco , Kazandjian Dickran , Bilbao Daniel , Chapman Jennifer , Landgren Ola , Hoffman James , Taylor Justin
Published: October 2022

Patients with multiple myeloma-bearing translocation t(11;14) have recently been shown to benefit from the apoptosis-inducing drug venetoclax; however, the drug lacks FDA approval in multiple myeloma thus far due to a potential safety signal in the overall patient population. Selinexor is an inhibitor of nuclear export that is FDA-approved for patients with multiple myeloma refractory to multiple lines of therapy. Here, we report that in four patients with multiple myeloma with t(11;14), the concomitant administration of venetoclax and selinexor was safe and associated with disease response. Moreover, the combination was synergistic in t(11;14) multiple myeloma cell lines and caused decreased levels of Cyclin D1 (which is overexpressed due to the CCND1-IGH fusion) when given in combination as compared to single agents. These data suggest that the combination of venetoclax and selinexor is effective and t(11;14) may serve as a therapeutic marker for response and target for future clinical trials.
Explainable medical imaging AI needs human-centered design: guidelines and evidence from a systematic review
Authors: Chen Haomin , Gomez Catalina , Huang Chien-Ming , Unberath Mathias
Published: October 2022

Transparency in Machine Learning (ML), often also referred to as interpretability or explainability, attempts to reveal the working mechanisms of complex models. From a human-centered design perspective, transparency is not a property of the ML model but an affordance, i.e., a relationship between algorithm and users. Thus, prototyping and user evaluations are critical to attaining solutions that afford transparency. Following human-centered design principles in highly specialized and high stakes domains, such as medical image analysis, is challenging due to the limited access to end users and the knowledge imbalance between those users and ML designers. To investigate the state of transparent ML in medical image analysis, we conducted a systematic review of the literature from 2012 to 2021 in PubMed, EMBASE, and Compendex databases. We identified 2508 records and 68 articles met the inclusion criteria. Current techniques in transparent ML are dominated by computational feasibility and barely consider end users, e.g. clinical stakeholders. Despite the different roles and knowledge of ML developers and end users, no study reported formative user research to inform the design and development of transparent ML models. Only a few studies validated transparency claims through empirical user evaluations. These shortcomings put contemporary research on transparent ML at risk of being incomprehensible to users, and thus, clinically irrelevant. To alleviate these shortcomings in forthcoming research, we introduce the INTRPRT guideline, a design directive for transparent ML systems in medical image analysis. The INTRPRT guideline suggests human-centered design principles, recommending formative user research as the first step to understand user needs and domain requirements. Following these guidelines increases the likelihood that the algorithms afford transparency and enable stakeholders to capitalize on the benefits of transparent ML.
scRNA-seq generates a molecular map of emerging cell subtypes after sciatic nerve injury in rats
Authors: Lovatt Ditte , Tamburino Alex , Krasowska-Zoladek Alicja , Sanoja Raul , Li Lixia , Peterson Vanessa , Wang Xiaohai , Uslaner Jason
Published: October 2022

Patients with peripheral nerve injury, viral infection or metabolic disorder often suffer neuropathic pain due to inadequate pharmacological options for relief. Developing novel therapies has been challenged by incomplete mechanistic understanding of the cellular microenvironment in sensory nerve that trigger the emergence and persistence of pain. In this study, we report a high resolution transcriptomics map of the cellular heterogeneity of naïve and injured rat sensory nerve covering more than 110,000 individual cells. Annotation reveals distinguishing molecular features of multiple major cell types totaling 45 different subtypes in naïve nerve and an additional 23 subtypes emerging after injury. Ligand-receptor analysis revealed a myriad of potential targets for pharmacological intervention. This work forms a comprehensive resource and unprecedented window into the cellular milieu underlying neuropathic pain and demonstrates that nerve injury is a dynamic process orchestrated by multiple cell types in both the endoneurial and epineurial nerve compartments.
Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2
Authors: Cheshenko Natalia , Bonanno Jeffrey B. , Hoffmann Hans-Heinrich , Jangra Rohit K. , Chandran Kartik , Rice Charles M. , Almo Steven C. , Herold Betsy C.
Published: October 2022

Herpes simplex virus (HSV) receptor engagement activates phospholipid scramblase triggering Akt translocation to the outer leaflet of the plasma membrane where its subsequent phosphorylation promotes viral entry. We hypothesize that this previously unrecognized outside-inside signaling pathway is employed by other viruses and that cell-impermeable kinase inhibitors could provide novel antivirals. We synthesized a cell-impermeable analog of staurosporine, CIMSS, which inhibited outer membrane HSV-induced Akt phosphorylation and blocked viral entry without inducing apoptosis. CIMSS also blocked the phosphorylation of 3-phosphoinositide dependent protein kinase 1 and phospholipase C gamma, which were both detected at the outer leaflet following HSV exposure. Moreover, vesicular stomatitis virus pseudotyped with SARS-CoV-2 spike protein (VSV-S), but not native VSV or VSV pseudotyped with Ebola virus glycoprotein, triggered this scramblase-Akt outer membrane signaling pathway. VSV-S and native SARS-CoV-2 infection were inhibited by CIMSS. Thus, CIMSS uncovered unique extracellular kinase processes linked to HSV and SARS-CoV-2 entry.
Deciphering the transcriptional regulation of the catabolism of lignin-derived aromatics in Rhodococcus opacus PD630
Authors: Diao Jinjin , Carr Rhiannon , Moon Tae Seok
Published: October 2022

Rhodococcus opacus PD630 has considerable potential as a platform for valorizing lignin due to its innate “biological funneling” pathways. However, the transcriptional regulation of the aromatic catabolic pathways and the mechanisms controlling aromatic catabolic operons in response to different aromatic mixtures are still underexplored. Here, we identified and studied the transcription factors for aromatic degradation using GFP-based sensors and comprehensive deletion analyses. Our results demonstrate that the funneling pathways for phenol, guaiacol, 4-hydroxybenzoate, and vanillate are controlled by transcriptional activators. The two different branches of the β-ketoadipate pathway, however, are controlled by transcriptional repressors. Additionally, promoter activity assays revealed that the substrate hierarchy in R. opacus may be ascribed to the transcriptional cross-regulation of the individual aromatic funneling pathways. These results provide clues to clarify the molecule-level mechanisms underlying the complex regulation of aromatic catabolism, which facilitates the development of R. opacus as a promising chassis for valorizing lignin.
Reproducibility and Validity of Portable ED-XRF Instruments: A Comparison of Spectral and Quantitative Results from Belizean and Ethiopian Obsidian
Authors: Johnson Lucas R. Martindale , Drake B. Lee , Brandt Steven A. , Prufer Keith , Chase Arlen F.
Published: October 2022

Handheld or portable XRF (pXRF) instruments enable archaeologists with little or no training in physics or chemistry to conduct obsidian studies worldwide. During the last decade we have witnessed a rapid increase in their use, alongside an accompanying concern over data accuracy and precision, and by extension repeatability. Two issues plague research: the use of different makes and models of instruments without accounting for their differing equipment capabilities and a current absence of standardized obsidian calibration and operational procedures. In this chapter, we use an obsidian calibration that is factory installed in all Bruker Tracer Series instruments, derived from the use of multiple trace-element analysis techniques (INAA, LA-ICP-MS, and MD-ICP-MS) on a set of 40 specific obsidian source samples at the University of Missouri Research Reactor (MURR) (Glascock and Ferguson 2012). Here, we report on a comparative study of multiple calibrated instruments using effectively identical analytical and operational procedures to analyze disparate obsidian sets from an extensive quarry site in SW Ethiopia and the Maya site of Caracol in Belize. Our results demonstrate that variation between instruments is negligible within the constraints of this study. We also suggest that analysts follow specific assay procedures and disclose all instrument outputs (i.e., photon counts and ppm) if future research is to become more repeatable and comparable.
Metal–organic framework-derived porous ternary ZnCo2O4 nanoplate arrays grown on carbon cloth for simultaneous electrochemical determination of ascorbic acid, dopamine, and uric acid
Authors: Hu Zhikun , Zhao Peng , Li Jiawei , Chen Yuanyuan , Yang Huisi , Zhao Jiaying , Dong Jiangbo , Qi Na , Yang Mei , Huo Danqun , Hou Changjun
Published: October 2022

Metal–organic framework derived ternary ZnCo2O4 nanoplate arrays grown on carbon cloth as self-supporting electrode for electrochemical detection of AA, DA and UA.
An indium-111-labelled membrane-targeted peptide for cell tracking with radionuclide imaging
Authors: Pruller Johanna , Pham Truc Thuy , Blower Julia E. , Charoenphun Putthiporn , Volpe Alessia , Sunassee Kavitha , Mullen Gregory E. D. , Blower Philip J. , Smith Richard A. G. , Ma Michelle T.
Published: October 2022

An indium-111-labelled peptide binds to myeloma cells, enabling SPECT imaging of myeloma cell accumulation in lungs after intravenous administration. This is the first report of a radiolabelled cell-membrane binding peptide for cell tracking.
Direct measurement of the deposition of submicron soot particles on leaves of Platanus acerifolia tree
Authors: Tao Miaomiao , Liu Qingyang , Schauer James J.
Published: October 2022

Submicron soot particles (<1.0 μm in aerodynamic diameter) are responsible for global warming and health burdens worldwide.
Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice
Authors: Huang Zirui , Liu Yun , Liu Xiaoyan , Chen Kewen , Xiong Wenyu , Qiu Yuyang , He Xiaoyu , Liu Bin , Zeng Feng
Published: October 2022

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus through improving body weight, fasting blood glucose, insulin-related indicators, lipid indexes, inflammatory factors, histological pathology, and intestinal microbiota.
Photoactivatable tandem fluorescence imaging of organelles and their interplay monitoring
Authors: Zhang Zicong , Pan Wenping , Xie Yayu , Liu Kai , Gao Meng , Wang Yingjun
Published: October 2022

Most fluorescent probes can only be used for targeted imaging of single organelles, we herein develop a photoactivatable probe for tandem imaging of different organelles and in situ monitoring of their interplay with simple operation.
Graphene oxide membrane chemically modified by electron-transfer diazonium chemistry for efficient dye separation
Authors: Li Zhenjiang , Xing Yucheng , Liu Yan , Meng Alan , Fan Xiaoyan
Published: October 2022

By diazonium chemistry, nitrobenzene groups have been introduced to graphene oxide membranes as interlayer pillars like the surface oxygen-containing functional groups.
Flame-retardant effect of tannic acid-based intumescent fire-retardant applied on flammable natural rubber
Authors: Wang Jingchao , Wang Xueya , Zhou Ziwen , Liu Xiaoyang , Xu Meiming , Zhao Fa , Zhao Feng , Li Song , Liu Zhihua , Li Lin , Zhao Shuai
Published: October 2022

The ACT systems give synergistic effects on the flame retardancy and smoke suppression properties of NR.
Highly emissive planarizedB,N-diarylated benzonaphthoazaborine compounds for narrowband blue fluorescence
Authors: Nguyen Nhi Ngoc Tuyet , Mubarok Hanif , Lee Taehwan , Tran Thi Quyen , Jung Jaehoon , Lee Min Hyung
Published: October 2022

The incorporation of a naphthyl ring into the azaborine core led to blue to sky-blue fluorescence with unitary photoluminescence quantum yields, narrow full width at half maximum values, and small Stokes shifts.
Insights into antiradical mechanism and pro-oxidant enzyme inhibitor activity of walterolactone A/B 6-O-gallate-β-d-pyranoglucoside originating fromEuonymus laxiflorusChamp. usingin silicostudy
Authors: Quy Phan Tu , Dzung Nguyen Anh , Van Bay Mai , Van Bon Nguyen , Dung Doan Manh , Nam Pham Cam , Thong Nguyen Minh
Published: October 2022

In silicoevaluation of a novel compound isolated fromEuonymus laxiflorusChamp. for its ability as a hydroperoxyl radical scavenger and pro-oxidant enzyme inhibitor.
Development of Vang Danh anthracite as a cost-effective anode for sodium-ion batteries through a heat-treatment process
Authors: Le Minh Kha , Tran Thanh Nhan , Huynh Thi Kim Tuyen , Nguyen Van Hoang , Vo Duy Thanh , Tran Van Man , Le My Loan Phung
Published: October 2022

The treatment process of anthracite materials obtained from Vang Danh and their performance in Na-ion batteries.
Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ42oligomers by controlling their interactions with cell membranes
Authors: Yu Zhengxin , Guo Weijie , Patel Shrey , Cho Hong-Jun , Sun Liang , Mirica Liviu M.
Published: October 2022

Amphiphilic compounds with selectivity towards soluble Aβ42oligomers were developed. Cell imaging studies show the compounds can reduce the interactions between Aβ42oligomers and SH-SY5Y cell membranes, both in the presence and absence of Cu.
Dual targeting nanoparticles for epilepsy therapy
Authors: Hou Qinghong , Wang Lulu , Xiao Feng , Wang Le , Liu Xiaoyan , Zhu Lina , Lu Yi , Zheng Wenfu , Jiang Xingyu
Published: October 2022

Dual-targeting nanoparticles containing D-T7 peptide and Tet1 peptide were designed for carrying lamotrigine (LTG) to cross the blood–brain barrier and further concentrate at the epilepsy lesions for treating epilepsy with high biosafety.
Design of an activatable NIR-II nanoprobe for the in vivo elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations
Authors: Lai Yi , Dang Yijing , Sun Qian , Pan Jiaxing , Yu Haijun , Zhang Wen , Xu Zhiai
Published: October 2022

A biocompatible Fe3O4 nanoparticle integrating methylglyoxal-activatable NIR-II fluorescent probe and brain-targeting peptide was developed for visualizing Alzheimer's disease (AD)-related methylglyoxal variation in vivo.
An anthracene-9-carboxylic acid-based [Cu20] cluster templated by a bromine anion for heterogeneous catalytic chemical fixation of carbon dioxide
Authors: Dong Dapeng , Tian Xueqin , Wu Pengyan , Wang Jian , Huang Jindou , Zhao Haiyan , Liu Dedi , Zhang Zhenyi
Published: October 2022

A highly stable copper-oxo cluster was constructed from the conjugated macromolecule anthracene-9-carboxylic acid templated by bromine anion as highly efficient heterogeneous catalyst for chemical fixation of carbon dioxide.
Designing and tuning the components of random terpolymers toward Ampere-hour-scale organic lithium batteries
Authors: Zhang Xiaoyin , Chen Ke , Tang Pei , Xiao Ru , Xu Ruogu , Yu Tong , Hu Guangjian , Cheng Hui-Ming , Sun Zhenhua , Li Feng
Published: October 2022

Terpolymer cathode materials are synthesized by designing and tuning their active components, functional groups and carbon backbones. In an A h-scale organic lithium pouch cell, the terpolymer cathode achieves a good cycling stability and a high energy density.
Extremophilic behavior of catalytic amyloids sustained by backbone structuring
Authors: Beasley Maryssa A. , Dunkelberger Adam D. , Thum Matthew D. , Ryland Elizabeth S. , Fears Kenan P. , Grafton Andrea B. , Owrutsky Jeffrey C. , Lundin Jeffrey G. , So Christopher R.
Published: October 2022

Catalytic amyloid materials remain structured in extreme temperature and solvent conditions, enabling enzyme-like function in synthetic environments.
Ionic and poly(ionic liquid)s as perovskite passivating molecules for improved solar cell performances
Authors: Mariotti Silvia , Mantione Daniele , Almosni Samy , Ivanović Milutin , Bessho Takeru , Furue Miwako , Segawa Hiroshi , Hadziioannou Georges , Cloutet Eric , Toupance Thierry
Published: October 2022

Ionic liquids and poly(ionic liquid)s act as bulk and/or passivation agents when used as additives in methylammonium-free lead perovskites, leading to devices showing enhanced power conversion efficiencies, reduced hysteresis and improved stability.
Novel spectral band: ultraviolet A mechanoluminescence from Bi3+-doped LiYGeO4
Authors: Shao Peishan , Xiong Puxian , Xiao Yao , Chen Qianyi , Sun Yongsheng , Yan Na , Chen Dongdan , Yang Zhongmin
Published: October 2022

Mechanoluminescence peaked at 355 nm (Bi3+:3P1→1S0) was observed in an orthorhombic phase compound of LiYGeO4:Bi3+, which has widened the mechanoluminescence spectral wavelength into UV range.
A nanosheet molding method to estimate the size of bilayers suspended in liquids
Authors: Sasaki Koki , Hernandez Gaitan Jose A. , Tokuda Yuki , Miyake Koji , Uchida Yoshiaki , Nishiyama Norikazu
Published: October 2022

We have successfully evaluated the dynamics of bilayers of the hyperswollen lamellar phase by observing palladium nanosheets growing in the bilayers. This method can measure the size of such stimuli-sensitive bilayer structures in situ.
A Scoping Review of Research Evaluating Physiological Information for Individuals With Developmental Disabilities: Augmentative and Alternative Communication Research Considerations
Authors: Holyfield Christine , O'Neill Zimmerman Tara
Published: October 2022

Purpose:

Today, an ever-increasing number of technological advancements are becoming mainstream. As the availability of technological innovations increases, so do opportunities for evaluating any benefits of those innovations in augmentative and alternative communication (AAC) research for individuals with developmental disabilities. One innovation that has become mainstream is the use of noninvasive wearable technology to provide physiological information (e.g., heart rate, skin conductance). Such information could be valuable in AAC research, but more information about its potential feasibility and utility is needed.

Method:

A scoping review was conducted to review and report on existing research that has evaluated (a) physiological information as a communication intervention tool for individuals with developmental disabilities and (b) the relationship between physiological information from individuals with developmental disabilities and behavioral and/or environmental information in real time.

Results:

Results revealed that, while little communication intervention research has been completed, descriptive research demonstrates that physiological information from individuals with developmental disabilities gathered using wearable technology corresponds meaningfully to observable environmental and behavioral events.

Conclusions:

Future AAC research incorporating wearable technology to gather physiological information is warranted. Such research could evaluate potential benefits such as preempting challenging behavior with communication opportunities, signaling readiness for language learning, indicating AAC feature preferences, and expanding methodological approaches.
Prosodic Development During the Early School-Age Years
Authors: Kallay Jeffrey E. , Dilley Laura , Redford Melissa A.
Published: October 2022

Purpose:

This study used a cross-sequential design to identify developmental changes in narrative speech rhythm and intonation. The aim was to provide a robust, clinically relevant characterization of normative changes in speech prosody across the early school-age years.

Method:

Structured spontaneous narratives were elicited annually from 60 children over a 3-year period. Children were aged 5–7 years at study outset and then were aged 7–9 years at study offset. Articulation rate, prominence spacing, and intonational phrase length and duration were calculated for each narrative to index speech rhythm; measures of pitch variability and pitch range indexed intonation. Linear mixed-effects (LME) models tested for cohort-based and within-subject longitudinal change on the prosodic measures; linear regression was used to test for the simple effect of age-in-months within year on the measures.

Results:

The LME analyses indicated systematic longitudinal changes in speech rhythm across all measures except phrase duration; there were no longitudinal changes in pitch variability or pitch range across the school-age years. Linear regression results showed an increase in articulation rate with age; there were no systematic differences between age cohorts across years in the study.

Conclusions:

The results indicate that speech rhythm continues to develop during the school-age years. The results also underscore the very strong relationship between the rate and rhythm characteristics of speech and so suggest an important influence of speech motor skills on rhythm production. Finally, the results on pitch variability and pitch range are interpreted to suggest that these are inadequate measures of typical intonation development during the school-age years.
Phonation Threshold Pressure as a Unique Outcome Measure of Phonatory Physiology Changes Following Submucosal Saline Injection for Vocal Fold Scarring
Authors: Ramanathan Pradeep , Yao Theresa Jingyun , Goding George S.
Published: October 2022

Purpose:

This study aimed to describe the utility of phonation threshold pressure (PTP) measurement as an additional outcome measure for changes in vocal fold vibration secondary to submucosal saline injection in the case of an individual with idiopathic vocal fold scarring.

Method:

An 8-week program of voice therapy, followed by submucosal saline infusion, was administered, using multiple outcome measures to assess voice quality, effort, and function in a 38-year-old woman with idiopathic bilateral vocal fold scarring. Transoral rigid video-endoscopy with stroboscopy in conjunction with the Stroboscopy Evaluation Rating Form provided measures of the vibratory characteristics of the vocal folds (amplitude, mucosal wave, nonvibratory portion, edge smoothness, and straightness). Auditory-perceptual measures were obtained using the Consensus Auditory-Perceptual Evaluation of Voice. Acoustic measures included jitter (%local), shimmer (%local), harmonics-to-noise ratio (dB), and Cepstral Spectral Index of Dysphonia. Additionally, PTP was measured 1 day prior to, and 1 month after, saline infusion.

Results:

Acoustic, auditory-perceptual, and stroboscopic variables suggested minimal change to the vibratory properties of the vocal folds in response to submucosal saline infusion for the treatment of vocal fold scarring. PTP measurements across the patient's frequency range, however, revealed a marked decrease post infusion. This was consistent with the patient's report of improved functioning and her request for repeat saline infusion.

Conclusion:

These results are consistent with the possibility of using PTP as an independent means of quantifying changes in phonatory physiology across the frequency range in patients with vocal fold scarring.

Supplemental Material:

https://doi.org/10.23641/asha.21313725
Get Out of Your Silo: A Qualitative Examination of an Interprofessional Undergraduate Course
Authors: Pfeiffer Danika L. , Pavelko Stacey L. , Bronaugh Dannette
Published: October 2022

Purpose:

Interprofessional collaboration in schools is fundamental to the success of all students. The purpose of this exploratory study is to examine the impact of an innovative one-credit-hour undergraduate course on students' knowledge of the Interprofessional Education Collaborative's (IPEC) core competencies for interprofessional practice.

Method:

Nine undergraduate students from communication sciences and disorders, inclusive early childhood education, and elementary education majors participated in two focus groups (one at the beginning and one at the end of the course). The researchers used a directed content analysis approach to analyze the data in terms of frequency and depth of the students' descriptions of the IPEC core competencies.

Results:

Two main findings emerged: (a) participants discussed the roles and responsibilities for collaborative practice (RR) and interprofessional teamwork and team-based practice (TT) competencies more frequently at the end of the course, and (b) participants discussed the RR, TT, and interprofessional communication practices competencies in a greater level of depth at the end of the course.

Conclusions:

These results suggest that a one-credit-hour course has the potential to enhance undergraduate students' knowledge of the IPEC core competencies in relation to school-based collaboration. Additional learning experiences for undergraduate students could include observations of co-teaching in schools, practicum experiences in which students have the opportunity to engage in co-teaching, and additional coursework on collaboration and teamwork.

Supplemental Material:

https://doi.org/10.23641/asha.21313722
Graduate Audiology Education and Student Perspectives on Over-the-Counter Hearing Aid Devices
Authors: Ramkissoon Ishara
Published: October 2022

Purpose:

While hearing care professions recently submitted commentary about proposed regulatory guidelines for over-the-counter (OTC) hearing aids, educational considerations were not highlighted much. This article examines audiology education regarding OTC devices, specifically addressing how graduate curricula may incorporate the topic and examining graduate audiology students' perspectives on proposed OTC regulations.

Graduate audiology curricula include a wide breadth of core classes and several specialized courses. The topic of OTC devices may fit well within graduate coursework focused on Professional Issues, Public Health, or Practice Management. This article presents the curricular option implemented at a mid-Atlantic university, including a brief course description, module overview for the OTC topic, and two related assignments. Graduate audiology training with a public health focus will generally address the core functions, assessment, policy, and assurance, which facilitates a topic such as OTC devices. This educational framework also optimized the examination of graduate students' views by qualitative analysis of assignment responses (
n
= 21) from audiology students. Thematic analysis of data revealed four themes with respective subthemes and categories. Major themes are examined in a discussion highlighting the perspectives of audiology graduate students.

Conclusions:

Regular teaching course audits facilitate curricular changes and may incorporate professional topics that are new, controversial, and/or in the development phase to optimize audiology curricular transformation. Analyzing student perspectives on current topics, such as OTC devices, provided an avenue for immersing public health audiology concepts into graduate training with an overall goal to improve equity and inclusion in clinical practice. The topic of OTC devices was appropriate for educating future audiologists.