bluuebunny/crossref_metadata_2025 huggingface dataset:
La polarización dinástica en los Países Bajos: la nobleza flamenca borbonista entre España y Francia (hacia 1670-1706)
Authors: Glesener Thomas
Published: October 2024

Este artículo arroja luz sobre el modo en que se construyó la adhesión a la sucesión borbónica en los Países Bajos. El estudio se centra en lo que puede describirse como la base social del borbonismo, a saber, un número relativamente reducido de familias nobles valonas de las provincias fronterizas con Francia. Ya integradas en la dinámica política francesa desde finales del siglo XVII, fueron las primeras en mostrar su adhesión a la nueva dinastía. Sin embargo, la ampliación del apoyo a Felipe V más allá de este primer círculo se debió, en gran medida, al interés de las élites flamencas por preservar las oportunidades que ofrecía la estructura imperial de la monarquía hispánica. Con la reforma del ejército de Flandes, que benefició en gran medida a las élites locales, los Borbones parecieron capaces de reforzar los vínculos entre Bruselas y Madrid.
Pompa y circunstancia. La real proclamación de Carlos IV en la capital del reino de Mallorca
Authors: Pascual Ramos Eduardo
Published: October 2024

Con la victoria borbónica en el reino de Mallorca se inaugura un nuevo modelo del ceremonial de proclamación real según el modelo castellano y de un monarca físicamente ausente, pero materializado simbólicamente a través de representaciones iconográficas. Este artículo estudia la real proclamación de Carlos IV en la capital del reino de Mallorca, Palma, con la descripción y el análisis de los aspectos más destacados de los días 11 y 14 de julio de 1789. Para ello se describen los principales actores, cómo se organizó la ceremonia y se estudia a sus protagonistas. Un último apartado está centrado en los gastos y su financiación.
Movimentos Estudantis no contexto escolar brasileiro e o olhar da Psicologia Escolar Crítica: Uma revisão sistemática
Authors: Republicano Clarisse , Pedraça Freitas Ícaro , Rosa Rodrigues Bárbara Delourdes , Negreiros Fauston
Published: October 2024

O artigo buscou realizar uma revisão sistemática acerca da literatura que versa sobre o movimento estudantil no Brasil, publicada entre 2015 e 2022, com o objetivo de quantificar artigos sobre essa temática e como a atuação da psicologia escolar no movimento estudantil secundarista brasileiro é abordada. A pesquisa foi realizada em 4 etapas: busca bibliográfica em 5 plataformas de periódicos, exclusão por título e de artigos duplicados, categorização dos estudos por área do conhecimento e análise dos artigos da área de Psicologia. O número total de artigos encontrados inicialmente foi 422 artigos. Após aplicar-se alguns critérios de inclusão e exclusão, realizamos a análise em 16 artigos. A partir dos resultados obtidos, pôde-se perceber a prevalência de pesquisas empíricas e qualitativas, estudando principalmente as ocupações secundaristas e experiências de construções de grêmios estudantis em escolas. Por fim, conclui-se que a temática estudada, ao se tratar de um fenômeno interdisciplinar, ainda é pouco explorada pela Psicologia. No entanto, os resultados obtidos na revisão, indicaram que é de fundamental importância a participação do estudante no processo político escolar, como materialização do objetivo que a escola tem na constituição de sujeitos em desenvolvimento aptos para atuarem em transformação social, ética e política.
Labor Market Dynamics in the Far Eastern Federal District: Q1 2023 – Q2 2024
Authors:   Economic Research Institute FEB RAS, Bravok Polina
Published: October 2024

Based on statistical, analytical and expert information, the article examines trends in the main parameters of the labor market as a whole and in the context of the constituent entities of the Russian Federation within the Far Eastern Federal District. The list of studied indicators characterizing the labor market includes: the number of workers aged 15 years and older, the number of employed and the employment rate, employment in the informal sector of the economy, the number of unemployed and the unemployment rate, the number of workers required for vacant jobs, the ratio of dismissed and employed employees of organizations. The analysis period is six quarters: starting from Q1 2023 to Q2 2024. Official publications and operational data of Rosstat were used as information sources. It is shown that the situation in the labor market remains tense against the background of an increasing shortage of labor resources and a decrease in the unemployment rate
PROJEKCIJA PROIZVODNJE MLEKA V SLOVENIJI
Authors: ČEPIN S. , FERČEJ J. , ČEPON M.
Published: October 2024

V letih od 1985 do 1994 se je v Sloveniji zmanjšalo število vseh goved za 17,3 %, število vseh krav za 20,2 % in število krav s tržno prirejo mleka za 21,5 %. V istem obdobju je bila količina odkupljenega mleka razmeroma konstantna in se je gibala med 350 in 390 milioni litrov. Povečala se je količina tržnega mleka po kravi za 36,5 % (od 1990 litrov v letu 1985 na 2716 litrov v letu 1994), kar pomeni povprečno letno stopnjo 4 %. Zaradi predvidenega nadaljnega intenziviranja prireje mleka in razmeroma ustaljene porabe, se bo v Sloveniji tudi v bodoče zmanjševalo število krav za tržno prirejo mleka. Ob podobni povprečni stopnji povečevanja prodanega mleka po kravi, bomo lahko koncem naslednjih desetih letih odkupili enako količino mleka od okrog 100 000 krav. Izhajajoč iz strukture kmetijskih zemljišč v Sloveniji (64,5 % travinja), potrebujemo že zaradi preprečevanja zaraščanja kmetijskih površin in ohranjanja poseljene in kulturne krajine, vsaj 230 000 krav oziroma 580 000 glav goved. Istočasno pa je navedeni stalež goved potreben tudi za željeno prirejo govejega mesa. Prireje mleka v Sloveniji ne smemo obravnavati ločeno, ampak v sklopu celotne govedoreje oziroma celotnega kmetijstva.
PRIKAZ POTEKA AP KONTROLE Z RAČUNALNIŠKEGA VIDIKA
Authors: DOLINAR Anka , POGAČAR J. , KLOPČIČ Marija
Published: October 2024

Za sprotno in hitro spremljanje proizvodnje mleka krav vključenih v AP kontrolo so bili izdelani določeni računalniški programi. Ti omogočajo ne samo več vrst kontrole podatkov tako pri vnosu kot pri obdelavi, pač pa tudi razne vrste izpisov, ki omogočajo rejcem, da sprotno spremljajo proizvodnjo vsake posamezne krave in tudi cele črede. Računalniški programi potrebujejo za svoje delo osnovno podatkovno zbirko iz katere črpajo podatke. Ta podatkovna zbirka se počasi povečuje, kar tudi vpliva na hitrost delovanja programov. Predvideni razvoj prihodnosti bo temeljil na čim bolj avtomatskem vnosu podatkov v računalnik ter na povezavi različnih računalnikov med seboj.
ECONOMY AND MARKETING IN DAIRY INDUSTRY
Authors: HUGHES D.
Published: October 2024

/
HIGH-TECH STARTER CULTURES IN MILK PROCESSING
Authors: DE VUYST L.
Published: October 2024

Lactic acid bacteria are traditionally applied as starter cultures in industrial milk fermentation because of their favorable fermentation properties (lactose digestion, citrate utilization, proteolysis, bacteriophage resistance, slime production), their capacity to produce flavors (diacetyl, acetaldehyde), and their antimicrobial activity (organic acids, hydrogen peroxide, bacteriocins). Optimal physiological and process technological control of these metabolic traits allows the application of improved fermentation processes both in vitro and in situ. The use of molecular techniques and natural gene transfer methods has resulted in the selection and construction of lactic starter cultures with enhanced industrial properties. Moreover, novel lactic acid bacteria have been obtained by genetic, metabolic and protein engineering. This paper reviews the present state of the art and perspectives of engineering lactic acid bacteria for the improved production of milk products, flavors and additives.
BACTERIOCINS OF LACTIC ACID BACTERIA AS POTENTIAL BIOPRESERVATIVES
Authors: BOGOVIČ-MATIJAŠIĆ Bojana , ROGELJ Irena
Published: October 2024

The production of antagonistic substances by lactic acid bacteria (LAB) is well known and LAB are widely used in food preserving. Among antagonistic substances bacteriocins are very interesting. The interest for use of bacteriocins of LAB as natural antimicrobial compounds has appeared mainly because some of them are able to inhibit certain Gram-positive spoilage bacteria and food borne pathogens like Listeria monocytogenes, Staphylococcus aureus, Bacillus cereus and Clostridium butyricum. Bacteriocins of LAB could not fully substitute traditional preserving factors in food, but offer an additional hurdle. They can be introduced into foods as starter cultures, protective cultures or as additives in semi-purified, purified or pre-fermented form. Application of bacteriocins in foods is limited because of some characteristics: narrow activity spectrum, inactivation by proteolytic enzymes, binding to food components, too low "in situ" production, influence of intrinsic factors (pH, Aw), resistant strains. Some of those obstacles could be overcome by combining more bacteriocins or by genetically modifying bacteriocin producer. Until now only nisin and pediocins are industrially used, but many others are being tested on experimental level. Some promising examples of food preservation using bacteriocins or bacteriocins producing cultures are presented.
Poziom akceptacji dla feminatywów wśród osób studiujących i pracujących na UAM. Kontekst płci i statusu na uczelni
Authors: Zachorska Martyna F. , Klon Weronika , Waszyńska Katarzyna
Published: October 2024

The purpose of the project was to investigate the level of acceptance of feminine forms of job titles (feminitives) in the academic community of Adam Mickiewicz University in Poznan (The context of gender and university status). The survey was conducted using the Qualtrix platform. The names of professions were selected from the alphabetical index of professions and specialties (2014). Ultimately, 102 occupation names and 11 function names were used in the survey. The respondents were told to define their own level of acceptance of each feminine form on a six-point scale from 0 to 5. The research group consisted of full-time students and academic staff (364 people) working at Adam Mickiewicz University, Poznań.
System opieki nad małym dzieckiem w Danii z perspektywy osób rozważających emigrację
Authors: Kubiak Hanna , Kubiak Ewa
Published: October 2024

The purpose of this article is to present the Danish childcare system before starting school, to analyze the types of care available and its provision in the context of children’s developmental needs. The text describes types and terms of care and the care facilities. It also indicates the principles of the pedagogical plan, what values it reflects and what aspects of care and upbringing are paid attention to in Denmark. The system is described in the context of the assumptions of developmental psychology, and so the basis of the assumptions for caring for children and supporting their development is defi- ned. The developmental effects of implementing the pedagogical plan are analyzed.
Panna Addams: współczesna tożsamość „z pogranicza”. O postawie głównej bohaterki serialu Wednesday
Authors: Pilawska-Gronostaj Roksana
Published: October 2024

The article is a part of qualitative interpretive research conducted as part of a doctoral thesis addressing the portrayal of femininity in contemporary selected film fairytales. The aim of the analysis was to present fairy tale heroines as an audiovisual representation of expectations, norms, and values stemming from gender and inscribed in the prevailing socio-cultural order. The qualitative interpretation of the active stance of the main character in the popular series Wednesday serves as an exe mplification of cultural contestation between the traditional understanding of femininity and its androgynous redefinition, not constrained by widely accepted social norms.
Vanishing theorems for Mather–Jacobian multiplier ideals on a Gorenstein projective variety
Authors: Niu Wenbo
Published: October 2024

In this paper, we establish several results related to vanishing theorems for Mather–Jacobian multiplier ideals on a Gorenstein projective variety, including an injectivity theorem, a Nadel-type vanishing theorem, a Griffiths-type vanishing theorem for vector bundles, and a vanishing theorem for the asymptotic Mather–Jacobian multiplier ideals.
Convex Fujita numbers are not determined by the fundamental group
Authors: Chen Jiaming , Küronya Alex , Mustopa Yusuf , Stix Jakob
Published: October 2024

We study effective global generation of adjoint line bundles on smooth projective varieties. To measure the effectivity we introduce the concept of the convex Fujita number of a smooth projective variety and compute its value for a class of varieties with prescribed dimension d ≥ 2 and an arbitrary projective group as fundamental group.
A histomorphometric study to evaluate the therapeutic effects of biosynthesized silver nanoparticles on the kidneys infected with Plasmodium chabaudi
Authors: Murshed Mutee , Al-Tamimi Jameel , Ibrahim Khalid Elfaki , Al-Quraishy Saleh
Published: October 2024

The study aimed to verify the pathogenic malarial kidney infections and histopathological pictures in mice infected with Plasmodium chabaudi using Indigofera oblongifolia leaf extract silver nanoparticles (IOLEAgNPs). Fifty healthy adult female mice C57BL/6 were used. Animals were divided into five groups, with each group of ten mice. The first control non-infected group was given distilled water for 7 days. The second group was orally given 50 mg/kg of IOLEAgNPs. The third, fourth, and fifth groups were injected intraperitoneally with 105 parasitized erythrocytes of P. chabaudi. After 1 h, the fourth group received 50 mg/kg of IOLEAgNPs, while the fifth group orally received 10 mg/kg chloroquine phosphate. The histopathology of the kidney was studied by routine histology method with hematoxylin–eosin staining. The kidney revealed cerebral microvessel congestion, hemorrhages, and necrosis. Cast formation, glomerulonephritis, tubular necrosis, and congestion were observed in the kidney cortex. Consequently, the targeted medical IOLEAgNPs reduced this degeneration impact on renal tissue. Proven that plant-source synthesized IOLEAgNPs play a preventive role as antimalarial agents in female mice infected with P. chabaudi.
Ruins of Empire or Tears of Joy? An Intersection of History and the Bible in Lope de Vega’s Religious Comedias
Authors: Vangshardt Rasmus
Published: October 2024

This article studies a way in which Lope de Vega used biblical theatre as a vehicle for historiographical interpretation. The article does so by situating elements from a number of Lope’s religious comedias in the context of what has recently been described as Golden Age Spain’s “aesthetic-historical culture.” The study begins with an analysis of intersections of history and the Bible in Lope’s La hermosa Ester. The second half comprises a reconstruction of the role of the Bible in Lope’s poetics. Via this two-pronged strategy, the article makes a case for seeing a feature of Lope’s biblical comedias as part of said aesthetic-historical culture of early modern Spain and proposes a way to understand the historiographical profile of Lope’s biblical drama. This leads to the claim that Lope’s biblical drama effectively contributed to the attribution of a new generic mixture to understandings and interpretations of the course of history itself. This interpretation invites a highly open-ended approach to the end of time between ruin and redemption.
The acquisition of sociolinguistic variation by multilingual merchants: the case of seventeenth-century Spanish
Authors: Sánchez Vicente Andrea
Published: October 2024

This article analyzes an unpublished corpus of 131 letters written in Spanish by four Dutch merchants during the seventeenth-century (1669–1677). The aim of the investigation is to determine whether the variation found in these letters was internal, external, or both, and to study the factors that favored each source. To do so, I will look at vowel variation in this corpus. Since standard vowel variants were being selected in seventeenth-century Spanish, the research questions addressed in this work are the following: Did multilingual merchants acquire the emerging standard of the moment? Did multilingual merchants contribute to the selection of standard variants? Did multilingual merchants acquire the sociolinguistic variation of that period? How did multilingual merchants differ from L1 speakers and why? How did linguistic and social factors influence this variation? The results revealed a great amount of intra- and inter-speaker vowel variation, and this variability was a matter of both internal and external factors. Therefore, this study argues that, while multilingual merchants acquired some of the standard variants that were being selected in the emerging standard Spanish of the seventeenth century, they reported linguistic variation that can be explained considering the context of use and the socio-economic conditions underlying their acquisition of linguistic repertoires.
Haghia Triada = da-wo or pa-i-to?
Authors: Monti Orazio
Published: October 2024

The data provided by the Linear B tablets from Knossos concerning the toponyms da-wo and pa-i-to, compared with the archaeological finds at the site of Haghia Triada - in the Cretan Messara Plain - strongly suggest that the Linear B name of this site was da-wo, while pa-i-to indicated only Phaistos.
“Initial-a-final”, Luwian low vowels, and language contact in the Syro-Anatolian world
Authors: Burgin James M. , Yakubovich Ilya
Published: October 2024

The Anatolian hieroglyphic inventory features two phonetic signs conventionally translated as “a”: 〈a〉 = L. 450 and 〈a〉 = L. 19. Their distribution has eluded explanation due to the complicated conventions governing the use of the 〈a〉 sign, which can be placed at the end of a word (“initial-a-final”), replaced with 〈a〉 (“a-substitution”), or deleted (“a-deletion”). Some words also regularly change between 〈a〉 and 〈a〉 within their paradigm. Based on a more refined understanding of these conventions, which vary by period and location, and comparison with data from the closely related Lycian language and Luwian names in Greek transmission, it will be suggested that 〈a〉 and 〈a〉 corresponded to the low vowels /a/ and /ɑ/ respectively. It will be argued that distinction between the two vowels in Luwian ultimately arose from the Proto-Anatolian contrast between the short and long non-high vowels, but also in some instances from the Luwic umlaut (mostly anticipatory backing of /a/ to /ɑ/). New evidence is also put forth that the vowel system of some dialects of Late Luwian underwent a change due to contact with Semitic languages. This resulted in an orthographic reform beginning in the late 9th century BC, which has practical implications for the dating of certain inscriptions.
Possible Representations of Aker in
Heb-sed
Scenes Adorning Temple Entryways and their Cosmic Significance
Authors: Hamden Ahmed
Published: October 2024

This paper examines the unique representations of the separated heads on the ground line on the columns and gateways in the temple entryways associated with the Sed-festival. An analysis of the scenes shows that here are mutual iconographical and religious characteristics between this motif and the chthonic deity Aker. The focal point of the research is to study the known representations of these heads and present an additional hypothesis of attributing them to Aker.
Mariette’s Newly Released Documents and the Chronology of the Apis Bulls
Authors: Porter Robert
Published: October 2024

The Louvre Museum recently placed online Mariette’s notebooks from the mid 19th century which include information on the find-spots of stelae from the Lesser Vaults of the Memphis Serapeum, the underground tomb complex of the Apis bulls at Saqqara. Some of these stelae name the reigning pharaoh and/or give dates for the bulls. The tombs had been ransacked but it seems that enough stelae remained close to their original positions to help determine the approximate location of each bull burial, a subject which has long been debated. Analysis of Mariette’s documents suggests a greater overlap between Dynasties 22 and 25 than is generally accepted.
Spermidine protects cellular redox status and ionic homeostasis in D-galactose induced senescence and natural aging rat models
Authors: Singh Sandeep , Verma Avnish Kumar , Garg Geetika , Singh Abhishek Kumar , Rizvi Syed Ibrahim
Published: October 2024

Impaired redox homeostasis is an important hallmark of aging. Among various anti-aging interventions, caloric restriction mimetics (CRMs) are the most effective in promoting health and longevity. The potential role of spermidine (SPD) as a CRM in modulating oxidative stress and redox homeostasis during aging remains unclear. This study aimed to investigate the protective effect of SPD in D-galactose (D-gal) accelerated induced senescence model and naturally aged rats. Young male rats (4 months), D-gal induced (500 mg/kg b. w., subcutaneously) aging model and naturally aged (22 months) rats were supplemented with SPD (10 mg/kg b. w., orally) for 6 weeks. The results showed that SPD supplementation suppresses the age induced increase in reactive oxygen species, lipid peroxidation and protein oxidation. Additionally, it increases the level of antioxidants, plasma membrane redox system in erythrocytes and membrane. These results also indicate that membrane transporter activity is correlated with the susceptibility of the erythrocyte towards oxidative damage. We therefore present evidence that SPD improves redox status and membrane impairments in erythrocytes in experimental and naturally aging rat models, however, more research is required to recommend a potential therapeutic role for SPD as an anti-aging intervention strategy.
GABA-Induced Seizure-Like Events Caused by Multi-ionic Interactive Dynamics
Authors: Liu Zichao , De Schutter Erik , Li Yinyun
Published: October 2024

Experimental evidence showed that an increase in intracellular chloride concentration([Cl−]i)caused by gamma-aminobutyric acid (GABA) input can promote epileptic firing activity, but the actual mechanisms remain elusive. Here in this theoretical work, we show that influx of chloride and concomitant bicarbonate ion(HCO3−)efflux upon GABA receptor activation can induce epileptic firing activity by transition of GABA from inhibition to excitation. We analyzed the intrinsic property of neuron firing states as a function of[Cl−]i. We found that as[Cl−]iincreases, the system exhibits a saddle–node bifurcation, above which the neuron exhibits a spectrum of intensive firing, periodic bursting interrupted by depolarization block (DB) state, and eventually a stable DB through a Hopf bifurcation. We demonstrate that only GABA stimuli together withHCO3−efflux can switch GABA's effect to excitation which leads to a series of seizure-like events (SLEs). Exposure to a low[K+]bathcan drive neurons with high concentrations of[Cl−]idownward to lower levels of[Cl−]i, during which it could also trigger SLEs depending on the exchange rate with the bath. Our analysis and simulation results show how the competition between GABA stimuli-induced accumulation of[Cl−]iand[K+]bathapplication-induced decrease of[Cl−]iregulates the neuron firing activity, which helps to understand the fundamental ionic dynamics of SLE.
The U.S. Border Patrol
Authors: Gutiérrez Ramón A.
Published: October 2024

The year 2024 marks the centennial of the Border Patrol’s creation. This essay is an overview of how border policing on the Mexican border started, how it has been supervised over the past century, and how different presidential administrations and congresses have fashioned legislation to address America’s labor needs, vacillating between recruitment and expulsion drives.
Brushes with History
Authors: Sackman Douglas C.
Published: October 2024

Against a backdrop of other murals marking national territories and Manifest Destiny—notably, William Leutze’s stereochrome Westward the Course of Empire Takes Its Way completed for the U.S. Capitol during the Civil War, with its iconic depiction of a mostly monochrome van of westward migrants on their way over mountains to California’s Golden Gate—this article focuses on the way artists Judy Baca and Ana Teresa Fernández have both deconstructed physical and symbolic walls to open up a view of migrations across the U.S.–Mexico border as natural. The essay examines how each artist’s work gets to the same end vision but through different starting points in relation to history. Baca—in her ongoing History of California (a.k.a., the Great Wall of Los Angeles), and in her mural La Memoria de Nuestra Tierra, California—has brought repressed or erased history and people to light, and she explicitly envisions the border wall as unnatural. By contrast, Fernández optically erases the border wall at Tijuana / San Ysidro / the Pacific and other places along la frontera, employing Martha Stewart paint to create chinks and gashes in the wall’s ideological veneer, brushing blue onto corroding iron to, she says, pull “down the sky to kiss the ground again.” Baca represents what has been erased while Fernández erases what has been represented, but both do so to reconnect a California landscape that has been bifurcated by the border wall. Considered in relation to the history and historiography of the U.S.–Mexico borderlands—and in particular to work on the physical manifestation of the border through markers, monuments, fences and walls designed to split lands and peoples—this article considers these artists’ work as powerful demurrals, defiant visual protests and imaginaries that affirm inclusion, empathy, and human and ecological connections across the border between Alta and Baja California.
Cellular mechanisms of RET receptor dysfunction in multiple endocrine neoplasia 2
Authors: Walker Timothy J , Mulligan Lois M
Published: October 2024

Graphical abstract

Rearranged during transfection (RET) is a developmentally important receptor tyrosine kinase that has been identified as an oncogenic driver in a number of cancers. Activating RET point mutations gives rise to the inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN2), characterized by medullary thyroid carcinoma. There are two MEN2 subtypes, MEN2A and MEN2B, that differ in tumour aggressiveness and the associated constellation of other disease features, which are caused by distinct patterns of RET amino acid substitution mutations. MEN2A-RET mutations affecting extracellular cysteine residues promote ligand-independent dimerization and constitutive RET activity, while MEN2B is caused by a single amino acid change in the tyrosine kinase domain of RET, releasing autoinhibition and producing a more active MEN2B-RET kinase that can promote signalling as monomers or dimers in the absence of a ligand. These mutations cause intrinsic biochemical changes in the RET structure and activation but also trigger extrinsic effects that alter RET cellular location, interactions and mechanisms of downregulation that can prolong or mislocate RET activity, changing or enhancing functional outcomes. Furthermore, changes in specific combinations of RET-mediated effects associated with different mutations give rise to the distinct MEN2 disease phenotypes. Here, we discuss the current understanding of the intrinsic and extrinsic characteristics of RET MEN2A cysteine and MEN2B mutants and how these contribute to transforming cellular processes and to the differences in tumour progression and disease aggressiveness.
RGD peptide promotes follicle growth through integrins αvβ3/αvβ5 in three-dimensional culture
Authors: Matsushige Cassandra , Kitazumi Kaelyn , Beaman Amanda , Miyagi Marissa , Tallquist Michelle D , Yamazaki Yukiko
Published: October 2024

In brief

Three-dimensional ovarian tissue culture is a unique model to define the effects of molecules on folliculogenesis. Using this model, we determined that RGD–integrin interaction plays a role in antrum formation and theca cell differentiation.

We recently developed a three-dimensional (3D) ovarian tissue culture system supported by bacterial-derived dextran hydrogel. Arg-Gly-Asp (RGD) is an extracellular matrix-derived triple peptide. Immature ovarian tissues cultured in RGD-modified dextran hydrogel significantly promoted antral follicle growth and oocyte quality compared with those cultured in dextran hydrogel alone. In this study, we examined the mechanism of follicle growth stimulated by RGD treatment in the 3D system. First, we detected that direct contact between RGD-modified dextran hydrogel and ovarian interstitial cells is necessary to promote antral follicle growth. Therefore, we hypothesized that RGD stimulates antral follicle growth through RGD-binding integrin receptors expressed in the interstitial cell mass. Using quantitative PCR (qPCR) and immunochemical staining, we identified that integrins ⍺vβ3 and ⍺v5 are predominantly expressed in the ovarian interstitial compartment. To assess the effect of RGD–integrin interaction on follicle growth, ovarian tissues were cultured with cilengitide (Ci), an inhibitor specific for ⍺vβ3 and ⍺vβ5. Ci treatment suppressed RGD-induced follicle growth and oocyte quality in a dose-dependent manner. When the interstitial cell aggregates were cultured with RGD, cell migration and theca-related gene expression were significantly upregulated. Ci treatment dramatically suppressed these RGD-induced activities. In coculturing the interstitial aggregate and secondary follicles with RGD, migrating cells formed the outermost cell layers around the follicles, like theca layers, which were totally blocked by Ci treatment. In conclusion, our results suggest that RGD stimulates theca cell differentiation in the ovarian interstitial cells through integrins ⍺vβ3 and ⍺v5 to promote antral follicle growth in our 3D system.
ОЦЕНКИ РАЗБАЛАНСИРОВКИ ЗАГРУЗКИ ПРОЦЕССОРОВ ПРИ РАСПАРАЛЛЕЛИВАНИИ РЕШЕНИЯ 3D КРАЕВЫХ ЗАДАЧ НА КВАЗИСТРУКТУРИРОВАННЫХ СЕТКАХ
Authors: КЛИМОНОВ И.А. , КОРНЕЕВ В.Д. , СВЕШНИКОВ В.М.
Published: October 2024

Проведены исследования влияния разбалансировки загрузки процессоров при распараллеливании решения 3D краевых задач на квазиструктурированных параллелепипедальных сетках. Получены оценки влияния разбалансировки на время решения задачи в зависимости от числа процессоров и числа узлов сетки. Даны результаты численных экспериментов, подтверждающие теоретические предпосылки.

A study of the influence of unbalancing the processor load in parallelization of solutions of 3D boundary value problems on quasi-structured parallelepiped grids is carried out. Estimates of the influence of the unbalance on the time of solving the problems depending on the number of processors and the number of grid nodes used are given. The results of numerical experiments confirm the theoretical conclusions.
ЧУВСТВИТЕЛЬНОСТЬ ФУНКЦИОНАЛОВ К ВХОДНЫМ ДАННЫМ В ЗАДАЧЕ ВАРИАЦИОННОГО УСВОЕНИЯ ДЛЯ МОДЕЛИ ТЕРМОДИНАМИКИ МОРЯ
Authors: ШУТЯЕВ В.П. , ПАРМУЗИН Е.И.
Published: October 2024

Рассматривается задача вариационного усвоения данных наблюдений для модели термодинамики моря с целью восстановления потоков тепла на поверхности с учетом ковариационных матриц ошибок входных данных. Исследована чувствительность функционалов от решения к входным данным в рассматриваемой задаче вариационного усвоения и приведены результаты численных экспериментов для модели динамики Балтийского моря.

A problem of variational data assimilation for a sea thermodynamics model is considered, with the aim to reconstruct sea surface heat fluxes taking into account the covariance matrices of input data errors. The sensitivity of some solution functionals to input data in this problem of variational assimilation is studied, and the results of numerical experiments for a model of dynamics of the Baltic Sea are presented.
ЧИСЛЕННОЕ СТОХАСТИЧЕСКОЕ МОДЕЛИРОВАНИЕ ПРОСТРАНСТВЕННО НЕОДНОРОДНОЙ ПОПУЛЯЦИИ
Authors: ПЕРЦЕВ Н.В. , ТОПЧИЙ В.А. , ЛОГИНОВ К.К.
Published: October 2024

Построена непрерывно-дискретная стохастическая модель, описывающая эволюцию пространственно неоднородной популяции. Структура популяции задается в терминах графа с двумя вершинами и двумя однонаправленными ребрами. Граф отражает пребывание индивидуумов популяции в вершинах и их переходы между вершинами по ребрам. Индивидуумы поступают в популяцию из внешнего источника в каждую из вершин графа. Длительности перемещения индивидуумов по ребрам графа постоянны. Индивидуумы могут погибать или превращаться в индивидуумов других популяций, не рассматриваемых в модели. Сформулированы предположения модели, приведены вероятностная формализация модели и алгоритм численного моделирования, основанный на методе Монте-Карло. Исследованы законы распределения численности популяций. Представлены результаты вычислительного эксперимента.

A continuous-discrete stochastic model is constructed to describe the evolution of a spatially heterogeneous population. The population structure is defined in terms of a graph with two vertices and two unidirectional edges. The graph describes the presence of individuals in the population at the vertices and their transitions between the vertices along the edges. Individuals enter the population from an external source at each of the vertices of the graph. The duration of movement of individuals along the edges of the graph is constant. Individuals may die or turn into individuals of other populations not considered in the model. The assumptions of the model are formulated, the probabilistic formalization of the model and the numerical simulation algorithm based on the Monte Carlo method are given. Distribution patterns of the population are studied. The results of a computational experiment are presented.
Aristotle on Possibility and Necessity: Fragments from On Interpretation and On the Heavens
Authors: Pabijutaitė Živilė , Gricius Pranciškus , Jaskelevičius Alius
Published: October 2024

-
A szüléssel kapcsolatos attitűdök vizsgálata fiatal nők körében – személyorientált elemzés
Authors: Petróczki Petra , Lakatos Csilla , Martos Tamás , Sallay Viola
Published: October 2024

Elméleti háttér: A szüléssel kapcsolatos kognitív és affektív viszonyulási módokat szülésattitűdöknek nevezzük. A szüléssel kapcsolatos attitűdök vizsgálata kiemelt jelentőségű, mivel azok nagyban meghatározzák a szülés preferált módját és később magát a szülésélményt is. Cél: Kutatásunk célja az volt, hogy a szüléssel kapcsolatos attitűdöket személyorientált statisztikai módszerekkel vizsgáljuk annak érdekében, hogy a szüléshez való személyes viszonyulásról differenciáltabb képet kapjunk. Módszerek: Keresztmetszeti kérdőíves kutatásunkban még nem szült és nem várandós nőket vizsgáltunk (n = 302). Hierarchikus klaszterelemzést végeztünk, majd a kapott klaszterstruktúrát megvizsgáltuk az egészségműveltség, a gyakorlati egészségértés, az élettel való elégedettség és a szüléssel kapcsolatos tudás vonatkozásában is. Eredmények: Az eredmények szerint azonosítható egy hét- és egy négyklaszteres struktúra. A továbbiakban a négyklaszteres (Önállóan közelítő, Elkerülő, Külső támaszkereső, Bizakodó) megoldást vizsgáltuk. Ez alapján találtunk szignifikáns különbséget az élettel való elégedettség, az egészségműveltség, valamint a szüléssel kapcsolatos tudás mentén is a klaszterek között. A Bizakodó profil magasabb szubjektív egészségértéssel jellemezhető, mint az Elkerülő [F(3; 298) = 2,51; p = 0,059; η2 = 0,029], valamint magasabb az élettel való elégedettsége, mint a Külső támaszkereső, valamint az Elkerülő klaszterben [FWelch(3; 143,7) = 4,82; p = 0,003; FBrown-Forsythe (3;235,2) = 5,00; p = 0,002; η2 = 0,054]. Az Önállóan közelítő csoport szüléssel kapcsolatos tudása szignifikánsan magasabb bármely más profilénál [χ2(6) = 31,96; p < 0,001; Cramér-V = 0,188]. A profilok nem mutattak szignifikáns kapcsolatot a gyakorlati egészségértéssel. Következtetések: A szüléssel kapcsolatos attitűdök személyközpontú elemzése holisztikus képet adhat a fiatal nők szüléssel kapcsolatos elképzeléseiről és aggodalmairól. Emellett az eredmények megmutatják a szüléssel kapcsolatos attitűdök egyéni különbségeinek hátterét és más személyiségjellemzőkkel való kapcsolatát.
The Hyperreality of Identity Politics on Social Media
Authors: Hariyanto Didik , Dharma Ferry Adhi , Yussof Ishak , Muharram Fajar
Published: October 2024

Religious-based identity political content is widespread on social media, raising voter polarization and social conflict. This research revealed the religious commodification of political buzzers for political identity and the hyperreality created on social media to attack their political opponents with identity politics. It used a qualitative commodification perspective by Jean Baudrillard. The data source was identity political content produced by buzzers from 03 October 2022 to 03 May 2023 or since the NasDem Party declared Anies Baswedan a presidential candidate. The results suggested that political buzzers coordinatedly use religion as a political commodity to build hatred through the Kadrun hashtag. In the 2019 elections, this hashtag successfully created a radical stigma among groups supporting Prabowo-Sandi and is now used to attack Anies supporters. Besides, the hyperreality created by the buzzers is the symbolization of Arab Islam to label Anies and his supporters, and indigenous Islam to describe cultural Islamic groups or native Indonesian Islam. Through social media, Arab Islam is simulated as a group full of conflict and supporting the caliphate while indigenous Islam is a peace-loving and nationalist group, which leads to widespread social disintegration, not only among Muslims in the country but also sentiment among Arab descendants in Indonesia. The impact of extreme identity politics can encourage radicalization and violence, especially when there are narratives that manipulate feelings of injustice or threats to the identity of certain groups.
Wahbah Zuhaili's Understanding of the Verses on Adultery: A Review of Al-Tafsir Al-Munir
Authors: SAM Muhamad Nurbaden
Published: October 2024

Adultery has recently become a major problem faced by mankind, especially whether it is prostitution or abnormal-sex considering that this ugliness is among the oldest on earth, this crime is very difficult to deal with and even trying to reduce it is very difficult. This is made clear by the reading of the text of the Qur'an by the mufasir, so that in this study it is hoped that it will be able to trigger Wahbah Zuhaili's best interpretation of zina and its relevance to the Criminal Code in Indonesia. This research uses qualitative research methods, namely research that contains written data such as documents or other texts that are relevant to the topic of discussion, this written data is usually in the form of words or actions and not in the form of numbers (numeric). The collection of sources in this research was obtained by means of library research or book surveys. In this technique, there are three stages that must be done. First, inventorying the verses on adultery. Second, read, browse, and compile interpretations of wAhbzh zuhaili. Third, describe and analyze the interpretation of these adultery verses, so that comprehensive and holistic research findings or results can be obtained.
Revisiting Tafsir Hukmi: Unraveling the Legal Interpretation of the Quran and Its Historical Evolution
Authors: Nugraha Sandi , Yunus Badruzzaman M.
Published: October 2024

This paper aims to delve deeper into legal interpretation (Tafsir Hukmi) by examining the history of the emergence of legal approaches in the interpretation of the Quran, defining the scope of the term, exploring debates among scholars, and providing examples of Quranic exegesis books adopting legal approaches. The research methodology used is a literature-based descriptive analysis with a historical and exegetical perspective. The results of the study show that legal interpretation (Tafsir Hukmi) is one of the Quranic interpretation styles that employ legal theories and approaches. This approach has its roots dating back to the time of Prophet Muhammad and continued to evolve with the emergence of the school of jurisprudence (Imam Madzhab) scholars who had varying interpretations of Islamic jurisprudence. The scope of the term “Tafsir Hukmi” encompasses discussions related to the Islamic legal laws in the Quran. Quranic exegesis books following the legal approach can be found within various schools of thought, including Shia Imamiyah, Shia Zaidiyah, Maliki, Hanafi, Hanbali, Shafi'i, and Zahiri.
Empowerment of Rural Communities from the Perspective of the Quran: Towards Social Entrepreneurship through Village-Owned Enterprises
Authors: Tirmidzi Ayi Yusri Ahmad , Riyadi Dedi Slamet
Published: October 2024

Poverty in Indonesia is often a concentrated issue in rural areas. Although the government has provided various incentives to improve the rural economy, the results have not brought significant change. This is due to the incomplete effectiveness of rural community empowerment management, resulting in a lack of creativity and innovation in villages. This article aims to explore the concept of community empowerment from the perspective of the Quran, using a social entrepreneurship model through Village-Owned Enterprises (BUMDes) as a solution to address rural poverty. The social entrepreneurship model is chosen because of its integration of social and economic issues and its invitation for the entire village community to participate in this change. Using a descriptive-analytic approach based on the thematic interpretation of the Quran, this article concludes that the Quran provides guidelines for community empowerment that include at least three crucial aspects: 1) opportunity, 2) capacity, and 3) authority. These three aspects form the basis for the implementation of social entrepreneurship through BUMDes in a way that has the potential and proportionality to empower rural communities. One example of a village that has successfully implemented this model is Kertayasa Village. To date, Kertayasa Village has achieved relative success in building social entrepreneurship through BUMDes. The success of this social entrepreneurship model reflects an approach that prioritizes social welfare collectively over individual economic gains.
Gender Equality Perspectives on Female Labor Force in West Bandung Regency
Authors: Subagja Yayang Hendri
Published: October 2024

Research conducted in West Bandung Regency, West Java, Indonesia, reveals that the challenges to achieving gender equality stem from differences in perspectives between men and women regarding rights, obligations, roles, and social status. One of these discussions often revolves around the issue of gender equality in the labor force, primarily concerning the rights and responsibilities guaranteed to Indonesian citizens by the 1945 Constitution. Gender equality in employment is both a governmental responsibility to protect citizens' rights and has cultural underpinnings. There still exist several institutional and socio-cultural barriers to improving gender equality in the workforce, including workers' awareness of their rights and the bargaining power of female employees. Therefore, it is believed that the government should play a crucial role in promoting gender equality by strengthening the enforcement of gender equality laws in the labor sector and enhancing labor market oversight. Furthermore, increasing awareness of gender equality among female workers and providing social protection for women in the informal sector is essential.
Kajian Metodologis dalam Kitab Tafsir Lathaif al-Isyarat Karya Imam al-Qusyairi
Authors: Ghoni Abdul , Fauji Hari
Published: October 2024

Tafsir Lathaif al-Isyarat, karya Imam al-Qusyairi, menciptakan harmoni antara ilmu syariat dan hakikat, mengklaim bahwa tidak ada kontradiksi di antara keduanya. Setiap tafsir tidak terlepas dari pengaruh latar belakang mufassir. Penelitian ini adalah kajian kepustakaan dengan fokus pada Tafsir Lathaif al-Isyarat sebagai sumber primer dan menggunakan buku serta jurnal sebagai referensi sekunder yang terfokus pada aspek metodologis. Tujuan penelitian adalah mengeksplorasi penafsiran Al-Qusyairi terhadap Lataif Al-Isyarat dan metodenya dalam penafsiran tersebut. Hasil penelitian menunjukkan bahwa Al-Qusyairi, sebagai sufi, mencoba menafsirkan ayat-ayat Al-Quran dengan konsep tasawuf dan bahasa sastra, membimbing pembaca ke dalam perasaan jiwa sufi. Hal ini penting dalam konteks pembelaan terhadap tasawuf pada masa Sultan Thaghral. Dari segi metodologi, Al-Qusyairi menggunakan metode tahlili untuk menganalisis isi ayat Al-Quran dari berbagai aspek tasawuf. Sumbernya mencakup bacaan akal dan isyarat, walaupun isyarat akalnya tidak murni, tetapi digunakan untuk tetap berpegang pada nash Al-Quran. Dalam hal corak, Al-Qusyairi menggabungkan tasawuf dan psikologi dengan simbol sastra, menerapkan konsep maqamat dan ahwal secara kreatif. Komentar ulama menyatakan bahwa tafsir ini tidak memihak pada hakikat atau syariat, menjunjung tinggi keadilan, dan menentang kebid'ahan. Kesimpulannya, Tafsir Lathaif al-Isyarat bukan hanya karya sufi, tetapi juga hasil pemikiran kreatif yang mencoba menyatukan berbagai konsep dengan mempertahankan nilai-nilai Islam.
Każb dalam Al-Qur'an: Analisis Linguistik Struktural Ferdinand de Saussure
Authors: Midrar Sa'dina Ahmad
Published: October 2024

Każb adalah salah satu kata yang sering diulang-ulang dalam Al-Qur'an. Pengulangan kata kazb dibagi menjadi derivasi dari dua belas każb dalam Al-Qur'an. Każb diletakkan sesuai dengan struktur kalimat dan makna yang terkandung di dalamnya. Sehingga penempatan derivasi każb dalam al-Qur'an sesuai dengan konteks pembahasan di dalamnya. Pembahasannya cenderung pada ranah sosial dan kepercayaan. Oleh karena itu, menarik untuk menganalisisnya dengan menerapkan analisis terstruktur. Tujuan dari penelitian ini adalah untuk mengetahui derivasi każb dalam Al-Qur'an dan menjelaskan struktur yang terkandung dalam derivasi Kazb dalam Al-Qur'an dengan menggunakan analisis struktural-linguistik Ferdinand de Saussure. Penelitian ini menggunakan metode penelitian kepustakaan dan menggunakan pendekatan linguistik struktural yang dikemukakan oleh Ferdinand de Saussure yang terdiri dari 4 tahapan analisis, yaitu penanda, langue parole, sinkronis-diakronis, dan sintagmatik-paradigmatik. Analisis data menggunakan model tematik yang melalui tahapan sebagai berikut: 1) mengumpulkan dan mengklasifikasikan data primer berupa ayat-ayat Al-Qur’an yang mengandung turunan każb, 2) memfokuskan pada data yang layak untuk dianalisis, 3) menyajikan hasil penelitian. data berupa deskripsi naratif pendek. Hasil penelitian ini menunjukkan bahwa secara struktural dan linguistik, istilah każb berkaitan dengan hati. Hal ini karena pembahasan każb dalam Al-Qur'an banyak berkaitan dengan keyakinan akan kebenaran ajaran Allah. Perkembangan makna każb yang diawali dengan makna keraguan pada periode klasik tafsir Al-Qur’an, menjadi upaya untuk menipu Allah dengan alibi keimanan pada periode kontemporer. Hal ini disebabkan pengaruh ilmu yang tidak diimbangi dengan kebaikan hati. Oleh karena itu, hati menjadi alat yang signifikan bagi kemajuan berpikir dan keindahan moralitas manusia.