bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase II trial of nivolumab with chemotherapy as neoadjuvant treatment in inflammatory breast cancer.
Authors: Kwa Maryann J. , Tray Nancy , Esteva Francisco J. , Novik Yelena , Speyer James L. , Oratz Ruth , Meyers Marleen Iva , Muggia Franco , Ty Victor , Troxel Andrea , Schneider Robert , Adams Sylvia
Published: May 2019

TPS604

Background: Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer with poor prognosis and is often resistant to neoadjuvant chemotherapy with risk of early recurrence and systemic spread of disease. PD-L1 expression in IBC is frequent (Bertucci et al. Oncotarget 2015), and blockade of the PD-1/PD-L1 axis with checkpoint inhibitors has emerged as a promising treatment to enhance anti-tumor immunity and clinical response. We hypothesize that PD-1 blockade with nivolumab in combination with neoadjuvant (primary) chemotherapy will increase the rate of pathologic complete response (pCR) and reduce risk of recurrence in patients with IBC. Methods: This is a single-arm open-label multicenter phase II study of nivolumab with neoadjuvant chemotherapy in patients with non-metastatic IBC (n = 52) (ClinicalTrials.gov: NCT03742986). All breast cancer subtypes (based on ER/PR/HER2) will be allowed. Patients will receive nivolumab 360 mg IV on day 1 (21-day cycle) for four cycles in addition to standard chemotherapy. Cohort 1 (patients with triple negative breast cancer or hormone receptor-positive (HR)/HER2-negative IBC) will receive nivolumab in combination with paclitaxel followed by doxorubicin and cyclophosphamide (AC). Cohort 2 (patients with HER2-positive IBC) will receive nivolumab in combination with a taxane (docetaxel or paclitaxel), trastuzumab, and pertuzumab followed by AC. All patients will then undergo mastectomy followed by radiation. The primary study objective is pCR rate (ypT0/Tis ypN0). Secondary objectives will be safety, tolerability and invasive recurrence-free interval. Association of correlative biomarkers with pCR and sensitivity or resistance to therapy with the combination of nivolumab and chemotherapy will be evaluated. Analyses will include mutational and neoantigen load, tumor-infiltrating lymphocytes (TILs) by histopathological assessment, T-cell receptor (TCR) by immunosequencing, and immune gene profiles in the tumor. PD-L1 expression in tumor tissue is not required for enrollment but will be assessed as a predictive marker. Clinical trial information: NCT03742986.
NSABP B-59/GBG 96-GeparDouze: A randomized double-blind phase III clinical trial of neoadjuvant chemotherapy (NAC) with atezolizumab or placebo in patients (pts) with triple-negative breast cancer (TNBC) followed by adjuvant atezolizumab or placebo.
Authors: Geyer Charles E. , Loibl Sibylle , Rastogi Priya , Seiler Sabine , Costantino Joseph P. , Nekljudova Valentina , Cortazar Patricia , Lucas Peter C. , Denkert Carsten , Mamounas Eleftherios P. , Jackisch Christian , Wolmark Norman
Published: May 2019

TPS605

Background: TNBC is associated with higher percentages of pathological complete response (pCR) to neoadjuvant chemotherapy (NAC), and women with a pCR have a favorable prognosis. However, Liedtke (2008) and Loibl (2017) found that women with residual disease have a substantially higher risk of recurrence than women with other subtypes of breast cancer. Additionally, Adams (2017) and Schmid (2017) found that therapeutic blockade of PD-L1 binding by atezolizumab has resulted in relevant anti-tumor efficacy. Methods: Design: This is a phase III, double blind, placebo-control trial evaluating neoadjuvant atezolizumab with NAC followed by adjuvant atezolizumab in TNBC. Pts are stratified by region (North America; Europe), tumor size (1.1-3.0cm; >3.0cm), AC/EC schedule (q2w; q3w), nodal status (positive; negative), and PD-L1 status (positive; negative or indeterminate) then randomized 1:1 to receive atezolizumab/placebo 1200 mg IV every 3 wks concurrently with both sequential regimens of weekly paclitaxel 80 mg/m2 IV for 12 doses with every 3-wk carboplatin AUC of 5 IV for 4 doses followed by AC/EC every 2-3 wks (per investigator discretion) for 4 cycles. Following surgery, pts resume atezolizumab/placebo 1200 mg IV every 3 wks as adjuvant therapy for 6 months. Radiotherapy based on local standards is co-administered with atezolizumab/placebo. Eligibility criteria: Centrally confirmed ER-neg, PR-neg, HER2-neg invasive breast cancer by ASCO/CAP guidelines. Primary tumor must be stage T2 or T3 if cN0 or cN1 with negative biopsy or T1c, T2, or T3 if cN1 with positive biopsy or cN2 or cN3. LVEF >55% and no significant cardiac history. Statistical methods: Co-primary endpoints are event-free survival (EFS) and pCR breast/nodes. Secondary endpoints include pCR breast, overall survival, distant disease-free survival, safety and toxicity. Trial is an academic collaboration between NSABP and GBG with support from Genentech/Roche. Support: Genentech/Roche. Clinical trial information: NCT03281954.
KEYNOTE-630: Phase 3 study of adjuvant pembrolizumab versus placebo in patients with high-risk, locally advanced cutaneous squamous cell carcinoma.
Authors: Geiger Jessica Lyn , Daniels Gregory A. , Cohen Ezra E.W. , Ge Joy Yang , Gumuscu Burak , Swaby Ramona F. , Chang Anne Lynn S.
Published: May 2019

TPS9597

Background: Among patients with high-risk, locally advanced (LA) cutaneous squamous cell carcinoma (cSCC) who receive current standard-of-care surgical resection and adjuvant radiotherapy, ~40-50% develop local recurrence and regional metastasis ( J Clin Oncol. 2018;36:1275-1283). Recent data suggest that programmed death 1 inhibitors such as pembrolizumab may provide a well-tolerated, effective, and durable response in patients with LA or metastatic cSCC. To evaluate the efficacy and safety of adjuvant pembrolizumab in patients with high-risk LA cSCC, the randomized, double-blind, placebo-controlled phase 3 KEYNOTE-630 trial (NCT03833167) will be conducted. Methods: After surgical resection and radiotherapy for high-risk LA cSCC, eligible patients will be randomly assigned 1:1 to intravenous pembrolizumab (400 mg Q6W) or placebo for up to 9 cycles (~1 year), with radiographic imaging at least every 12 weeks until year 2 and then every 6 months until the end of year 5 to assess treatment response. Eligibility criteria will include age ≥18 years, histologically confirmed LA cSCC with ≥1 high-risk feature at the primary site of malignancy, macroscopic resection with or without microscopic positive margins, completed adjuvant radiotherapy, disease free ≤28 days from randomization, and ECOG performance status 0-1. Treatment will be discontinued at disease recurrence, start of new anticancer treatment, unacceptable toxicity, intercurrent illness that prevents treatment, pregnancy, investigator or patient decision to withdraw, or administrative reasons that require treatment cessation. After the first disease recurrence, all patients who meet crossover or retreatment criteria may receive pembrolizumab 400 mg Q6W for up to 18 cycles. Adverse events will be monitored throughout the study and graded according to the NCI CTCAE, version 4.0. The primary efficacy end point will be investigator-assessed and biopsy-confirmed recurrence-free survival. Secondary end points will be overall survival, health-related quality of life, and safety. Recruitment is ongoing in 19 countries and will continue until approximately 570 patients are enrolled. Clinical trial information: NCT03833167.
CA045-001: A phase III, randomized, open label study of bempegaldesleukin (NKTR-214) plus nivolumab (NIVO) versus NIVO monotherapy in patients (pts) with previously untreated, unresectable or metastatic melanoma (MEL).
Authors: Khushalani Nikhil I. , Diab Adi , Ascierto Paolo Antonio , Larkin James M.G. , Sandhu Shahneen Kaur , Sznol Mario , Koon Henry B. , Jarkowski Anthony , Zhou Ming , Wang Rui , Bajaj Gaurav , Long Georgina V.
Published: May 2019

TPS9601

Background: Standard of care for pts with previously untreated, unresectable or metastatic MEL includes checkpoint inhibitors. Bempegaldesleukin is a CD122-preferential IL-2 pathway agonist designed to provide sustained signaling through the IL-2 βγ receptor to activate and proliferate effector CD8+ T and NK cells over T-regulatory cells in the tumor (Hurwitz ME et al. ASCO GU 2017). In the dose-expansion phase of the phase 1/2 PIVOT-02 trial, bempegaldesleukin + NIVO was well tolerated at the recommended phase 2 dose (RP2D; bempegaldesleukin 0.006 mg/kg IV Q3W + NIVO 360 mg IV Q3W), and previously untreated pts with MEL receiving the RP2D achieved an objective response rate (ORR) of 20/38 (53%) and a complete response of 9/38 (24%) by independent radiology review (Diab A et al. SITC 2018). Presented is the design of the first phase 3 trial in the bempegaldesleukin + NIVO development program in pts with previously untreated, unresectable or metastatic MEL. Methods: This phase 3, randomized, open-label study aims to evaluate the effectiveness, safety, and tolerability of bempegaldesleukin + NIVO (NCT03635983). Eligible pts are ≥12 y with histologically confirmed stage III (unresectable) or stage IV MEL and ECOG PS ≤1 or Lansky PS ≥80% (minors 12-17 y). Pts are ineligible if they have active brain or leptomeningeal metastases, uveal MEL, or a recurrence within 6 mo of completing adjuvant treatment with any approved agent. Pts will be stratified by PD-L1 status (measured using PD-L1 IHC 28-8 pharmDx), BRAF mutation status, and lactate dehydrogenase level, and will be randomized to receive bempegaldesleukin 0.006 mg/kg IV Q3W + NIVO 360 mg IV Q3W or NIVO 360 mg IV Q3W up to 24 mo, or until progression or unacceptable toxicity (N ~ 764). Primary endpoints are ORR and progression-free survival (PFS) by blinded independent central review (BICR) and overall survival (OS). Secondary endpoints include ORR and PFS by investigator, ORR and PFS by BICR in biomarker population, OS in biomarker population, and safety. Additional endpoints include pharmacokinetics and quality-of-life assessment. Clinical trial information: NCT03635983.
Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling
Authors: Lippincott Margaret F , León Silvia , Chan Yee-Ming , Fergani Chrysanthi , Talbi Rajae , Farooqi I Sadaf , Jones Christopher M , Arlt Wiebke , Stewart Susan E , Cole Trevor R , Terasawa Ei , Hall Janet E , Shaw Natalie D , Navarro Victor M , Seminara Stephanie Beth
Published: May 2019

Context

Kisspeptin–neurokinin B (NKB)–dynorphin neurons are critical regulators of the hypothalamic–pituitary–gonadal axis. NKB and dynorphin are hypothesized to influence the frequency of GnRH pulses, whereas kisspeptin is hypothesized to be a generator of the GnRH pulse. How these neuropeptides interact remains unclear.

Objective

To probe the role of NKB in GnRH pulse generation and to determine the interactions between NKB, kisspeptin, and dynorphin in humans and mice with a complete absence of NKB.

Design

Case/control.

Setting

Academic medical center.

Participants

Members of a consanguineous family bearing biallelic loss-of-function mutations in the gene encoding NKB and NKB-deficient mice.

Interventions

Frequent blood sampling to characterize neuroendocrine profile and administration of kisspeptin, GnRH, and naloxone, a nonspecific opioid receptor antagonist used to block dynorphin.

Main Outcome Measures

LH pulse characteristics.

Results

Humans lacking NKB demonstrate slow LH pulse frequency, which can be increased by opioid antagonism. Mice lacking NKB also demonstrate impaired LH secretion, which can be augmented with an identical pharmacologic manipulation. Both mice and humans with NKB deficiency respond to exogenous kisspeptin.

Conclusion

The preservation of LH pulses in the absence of NKB and dynorphin signaling suggests that both peptides are dispensable for GnRH pulse generation and kisspeptin responsiveness. However, NKB and dynorphin appear to have opposing roles in the modulation of GnRH pulse frequency.
Human-Specific Function of IL-10 in Adipose Tissue Linked to Insulin Resistance
Authors: Acosta Juan R , Tavira Beatriz , Douagi Iyadh , Kulyté Agné , Arner Peter , Rydén Mikael , Laurencikiene Jurga
Published: May 2019

Objective

Although IL-10 is generally considered as an anti-inflammatory cytokine, it was recently shown to have detrimental effects on insulin sensitivity and fat cell metabolism in rodents. Whether this also pertains to human white adipose tissue (hWAT) is unclear. We therefore determined the main cellular source and effects of IL-10 on human adipocytes and hWAT-resident immune cells and its link to insulin resistance.

Methods

Associations between hWAT IL-10 production and metabolic parameters were investigated in 216 participants with large interindividual variations in body mass index and insulin sensitivity. Adipose cells expressing or secreting IL-10 and the cognate IL-10 receptor α (IL10RA) were identified by flow cytometry sorting. Effects on adipogenesis, lipolysis, and inflammatory/metabolic gene expression were measured in two human primary adipocyte models. Secretion of inflammatory cytokines was investigated in cultures of IL-10–treated hWAT macrophages and leukocytes by Luminex analysis (Luminex Corp.).

Results

IL-10 gene expression and protein secretion in hWAT correlated positively with body mass index (BMI) and homeostasis model assessment-insulin resistance (HOMA-IR). Gene expression analyses in mature fat cells and flow cytometry–sorted hWAT-resident adipocyte progenitors, macrophages, and leukocytes demonstrated that the expression of IL-10 and the IL10RA were significantly enriched in proinflammatory M1 macrophages. In contrast to murine data, functional studies showed that recombinant IL-10 had no effect on adipocyte phenotype. In hWAT-derived macrophages and leukocytes, it induced an anti-inflammatory profile.

Conclusion

In hWAT, IL-10 is upregulated in proinflammatory macrophages of obese and insulin-resistant persons. However, in contrast to findings in mice, IL-10 does not directly affect human adipocyte function.
Bilateral Thoracic Paravertebral Blocks Compared to Thoracic Epidural Analgesia After Midline Laparotomy: A Pragmatic Noninferiority Clinical Trial
Authors: Sondekoppam Rakesh V. , Uppal Vishal , Brookes Jonathan , Ganapathy Sugantha
Published: May 2019

BACKGROUND:

Bilateral paravertebral block (PVB) is a suitable alternative to thoracic epidural analgesia (TEA) for abdominal surgeries. This randomized clinical trial aims to determine if PVB is noninferior to TEA in terms of analgesia after midline laparotomy.

METHODS:

Seventy American Society of Anesthesiologists (ASA) class I–III patients undergoing a laparotomy through a midline incision were randomized to receive either TEA (TEA group) or continuous bilateral PVB (PVB group) as a part of a multimodal analgesia regimen in an open-label design. Noninferiority was to be concluded if the mean between-group difference in pain on movement at the 24 postoperative hours was within a margin of 2 points on a 0–10 numerical rating scale (NRS). Pain score at rest and on movement, analgesic consumption, hemodynamics, and adverse events during the first 72 postoperative hours were the secondary outcome measures assessed for superiority. Postblock and steady-state plasma concentrations of ropivacaine and pattern of dye spread were also recorded in the PVB group.

RESULTS:

The primary outcome of pain scores on movement at 24 postoperative hours was noninferior in PVB group in comparison to TEA group (mean difference [95% confidence interval {CI}], 0.43 [−0.72–1.58]). The pain scores at rest and on movement at other time points of assessment were within clinically acceptable limits in both groups with no significant differences between the groups over time. Arterial plasma ropivacaine levels were within safe limits, while steady-state venous level was higher than an acceptable threshold in 9 of 34 cases.

CONCLUSIONS:

As a component of multimodal analgesia, bilateral PVB provides noninferior analgesia compared to TEA for midline laparotomy.
A revisão judicial das decisões proferidas pelo Conselho Administrativo de Defesa Econômica
Authors: Burg Amanda Karolini , Gonçalves Everton das Neves , Stelzer Joana
Published: May 2019

The judicial review of decisions rendered by the Brazilian Administrative Council of Economic Defense Neste trabalho busca-se verificar se, e em que medida, as decisões proferidas pelo Conselho Administrativo de Defesa Econômica (Cade) no controle estrutural e de condutas podem ser revisadas pelo Poder Judiciário. A metodologia de abordagem é indutiva; quanto ao método de procedimento, tem-se o monográfico; a técnica de pesquisa é documental e bibliográfica. Não há consenso acerca da natureza, discricionária ou não, das decisões proferidas pelo Cade. Mesmo assim, por meio de dados quantitativos e qualitativos, decorrentes de pesquisas empíricas elaboradas pela Sociedade Brasileira de Direito Público (SBDP) e por pesquisadores vinculados ao Conselho Nacional de Justiça (CNJ), é possível concluir que as decisões do Cade são objeto de revisão, inclusive de mérito, perante o Poder Judiciário. This paper aims to verify if, and to what extent, the decisions of the Brazilian Administrative Council of Economic Defense (Cade) can be reviewed by the Judiciary. The investigate methodology is inductive, the procedure method is monographic; and research technic is documental e bibliographical. There is no consensus if the decisions of the Cade are discretionary. Nevertheless, through quantitative and qualitative data, derived from empirical researches by the Brazilian Society of Public Law (SBDP) and by researchers of the Justice National Council (CNJ), it is possible to conclude that the decisions of the Brazilian Administrative Council of Economic Defense are subject to judicial review, even by merit.
Disciplina de mercado no setor bancário angolano: uma análise da monitorização realizada pelos depositantes
Authors: Mota Carlos
Published: May 2019

Este estudo analisa a disciplina do depositante bancário em Angola, um mercado emergente. Investiga se os depositantes são capazes de monitorizar os riscos bancários, reconhecendo e penalizando os bancos mais arriscados por meio das alterações nos depósitos e juros pagos. Utiliza os dados anuais de um painel de instituições bancárias angolanas, no período entre 2008 e 2017, para analisar o impacto e valor explicativo dos fatores de risco no comportamento dos depositantes. Os resultados sugerem não haver evidência consistente de disciplina de mercado. Os depositantes angolanos se mostram pouco receptivos ao risco bancário, após controle de outros fatores, e a capacidade explicativa global dos modelos de regressão é reduzida. No entanto, nem todos os fatores de risco evidenciam a mesma ausência de preponderância. Evidencia-se, ainda, que a disciplina não difere entre os vários grupos de bancos em função da proveniência e propriedade do capital e que a monitorização dos comportamentos de risco efetuada pelos depositantes não foi significativamente alterada pela crise econômica e financeira angolana.
Tailoring of Energy Band Gap inGraphene-like System by Fluorination
Authors: Nair Aparna V , Manoj B
Published: May 2019

Fluorinated grapheme has a two-dimensional layer structure with a wide band gap. In the present study, Fluoro Graphene (FG) is obtained from Graphene Oxide (GO) through a deoxyfluorination reaction with the aid of Diethylaminosulphurtrifluoride (DAST). The FT-IR exhibited a peak at 1216 cm-1 and the shoulder at 1312 cm-1 were ascribed to the stretching vibration of covalent C–F bonds and C–F2 bonds, respectively. Surface morphology revealed a leafy structure in GO and a rocky structure in FG. The EDS analysis confirmed the fluorination of the graphitic structure. The TEM analysis confirmed the formation of a mixed structure of graphene and carbon dots. The results of structural, morphological and electrical properties of both graphene oxide and fluorographene show the possibility of using these samples as electronic/electrochemical devices in future.
Aesthetics in Eje Festival at Ode Irele
Authors: Omosule Segun
Published: May 2019

The nature of Eje Festival in relation to gender is the subject of this study. The study deploys the tool of aesthetic as an instrument to particularly investigate the role of masquerades as a means of entertaining female members of the community periodically. Dwelling on aesthetics as a critical tool, the study unravels the performance of Eje Festival as a means of solving some perceived agrarian problems. The study concludes that the underlying reason behind the festival is subsumed in the quest for entertainment and the need for cohesion in the society especially as a means of enhancing the safety of members who might be married to people far and near.
Narratives of the Anthropocene: How can the (performing) arts contribute towards the socio-ecological transition?
Authors: Ribac François
Published: May 2019

In this article, I will examine the possible contribution that the (performing) arts have made to imagine the socio-ecological transition and the Anthropocene era. I will first examine the position occupied by narratives to document and explore these processes and the types of set-ups and approaches that are commonly used in artistic circles. I will then present two projects that were realized in recent years and will examine in particular their relationship with nature and their use of modern technologies. By steering clear of a normative approach, I will finally emphasize the space that these projects leave for their users, their potential dynamics and how they could inspire the performing arts.
Potential unlocked: Art in prison
Authors: Carpenter Benedict , Knight Victoria
Published: May 2019

This article introduces a three-year project begun in 2018 that investigates the relationship between visual arts education and mental health recovery for prisoners and probationers. The project is delivered in custodial contexts in Leicester, UK. The research engages young offenders with mental health conditions in creating visual artwork for public exhibition and publication. Insight into mental health recovery is gained through semi-structured interviews with participants. Participant well-being is coded through the CHIME framework. Some early findings are that the workshops help to alleviate the deep boredom of prison life; they are a useful distraction and an opportunity for introspection; they promote future thinking; and they help prisoners to connect with families. The research is aligned with the UN Sustainable Development Goal 3: Good health and wellbeing; and Goal 16: Promote peaceful and inclusive societies for sustainable development.
A case for ecoscenography: Cultivating the continuous potential of things in performance design
Authors: Beer Tanja
Published: May 2019

The Ecological Turn offers a unique perspective on the cyclic and continuous potentiality of things in scenographic practice. This Is Not Rubbish is an ecoscenographic project that investigates the journey of a material rescued from landfill, and its capacity to create immersive performance spaces and wearable artefacts. Inspired by new materialist notions of inhuman agency, the project seeks to dissolve the boundaries between more-than-human actants, installation and costume, site and material. The visual essay examines the potential for ecoscenography to lead to new modes of practice in scenography, where expanded ideas of material entanglement, across bodies, ecosystems and built environments, are central to performance design.
Reviews
Authors: Sporton Gregory , Sporton Gregory , Sporton Gregory
Published: May 2019

Life and Fate, adapted for the stage and directed by Lev Dodin, Maly Drama Theatre Company, Theatre Royal, Haymarket, 12 May 2018

Life is a Dream, by Kim Brandstrup, Rambert Dance Company, Sadler's Wells Theatre, London, 26 May 2018

New Work/New Music, The Royal Ballet, Royal Opera House, Linbury Theatre, 8 February 2019
The “Hawkers” case study: a model of the strategic use of the resources offered by digital environments
Authors: López-Navarrete Alberto-Jesús , López-Cepeda Ismael , Álvarez-Ruiz Antón
Published: May 2019

This study investigates the key to success of Hawkers, a Spanish company involved in the online marketing of sunglasses and a remarkable example of so-called start-ups. Starting up with a modest investment capital, this company, in becoming an internationally renowned brand, has quickly managed to achieve a high level of capitalization and an outstanding sales volume. To achieve this, Hawkers has developed an innovative management communication strategy on social media, adapting conventional marketing knowledge to online environments and reinterpreting traditional marketing practices in an original and effective manner. Furthermore, it has used an insightful sales strategy most effectively, turning customers into brand ambassadors with the aim of viralizing the brand content and developing growth partnerships with prominent companies and celebrities. The study is based on an analysis of key digital communication literature and insights provided by Hawkers, incorporating knowledge of new digital marketing techniques, observation and analysis of communication actions undertaken by the brand and measurement of its effectiveness through the available web metrics. The most important actions are detailed and the reason for their effectiveness explained through an analysis of communication mechanics applied with an emphasis on digital environments.
DISCUSSÃO E APLICAÇÃO DO PROTOCOLO THINK ALOUD EM PESQUISAS SOBRE PROCESSO DECISÓRIO
Authors: Dos Reis Lehnhart Eliete , Löbler Mauri Leodir , Tagliapietra Rafaela Dutra
Published: May 2019

Este estudo propõe uma discussão sobre os aspectos conceituais do protocolo verbal think aloud, utilizando-se de aplicações práticas num processo de decisão individual. Este trabalho apoia-se na revisão dos estudos dos principais autores do protocolo, especialmente Ericsson e Simon (1993). Sobre a aplicação do think aloud, são apresentados exemplos cujas pesquisas utilizaram o método experimental, cujo objetivo era compreender como os indivíduos tomavam decisões com e sem o auxílio de Sistemas de Apoio à Decisão (SAD). Os resultados do primeiro experimento revelaram que o processo decisório, utilizando um SAD, assemelhou-se apenas para a ordem de escolha dos critérios no que tange ao processo de decisão humana. Os resultados do segundo experimento, quando o indivíduo usou o SAD, permitiram verificar a relação entre duas das quatro estratégias de decisão propostas por Todd e Benbasat (1991). Sem o auxílio do SAD, todas as estratégias de decisão foram identificadas. Acredita-se que as aplicações elucidadas possam servir de orientação para futuras pesquisas, não somente no campo de processo decisório, mas em outras áreas que possibilitam o uso do protocolo think aloud.
ASPECTOS QUE INFLUENCIAM A EXPRESSÃO DE COMPETÊNCIAS DE PERITOS CRIMINAIS
Authors: Montezano Lana , Abbad Gardênia Da Silva
Published: May 2019

Este artigo tem por objetivo identificar aspectos que influenciam a expressão de competências de peritos criminais em uma organização pública brasileira. A pesquisa, exploratória-descritiva, com recorte transversal, foi feita com métodos qualitativos, por meio de pesquisa em documentos organizacionais relacionados ao tema e necessários à compreensão do contexto organizacional. Realizaram-se entrevistas com 19 gestores que atuam na área pericial e um grupo focal com técnicos da área de perícias criminais. Foram identificadas duas categorias de aspectos, as quais foram subdivididas em 11 subcategorias: Situacionais (suporte material, ambiente físico, políticas e práticas de gestão de pessoas, demanda de trabalho, apoio à gestão, suporte psicossocial, critérios de avaliação de resultados, estruturação organizacional e autonomia institucional) e individuais (motivação para o trabalho e estratégias de enfrentamento de situações adversas). Os participantes da pesquisa avaliaram mais favoravelmente o suporte material e o ambiente físico, e consideraram a motivação como uma importante variável preditiva da expressão de competências no trabalho. Os resultados mostraram que há aspectos de percepção de suporte organizacional semelhantes aos encontrados na literatura em outros contextos de trabalho e foram encontrados aspectos específicos não observados em estudos anteriores e não mensurados em contexto de atividade pericial.
Syphilis, The Great Mimicker, Presents As a Rare Case of Concurrent Hepatitis and Gastroparesis
Authors: Shinn Brianna , Kistler Charles , Dhanekula Raja Koteswar , Civan Jesse
Published: May 2019

Syphilis has been called “the great mimicker” given its ability to affect a wide variety of organs and subsequently present with a vast array of symptoms. The variability in clinical presentation seen in syphilis can make the diagnosis challenging. We describe a unique presentation of syphilis manifesting as hepatitis and gastroparesis. To our knowledge, this is the first case report with simultaneous hepatic and gastric involvement.
Impact of Preoperative Nutritional Status on the Incidence Rate of Surgical Complications in Patients With Inflammatory Bowel Disease With Vs Without Preoperative Biologic Therapy: A Case-Control Study
Authors: Yamamoto Takayuki , Shimoyama Takahiro , Umegae Satoru , Kotze Paulo Gustavo
Published: May 2019

OBJECTIVES:

A case-control study was undertaken to assess the impact of preoperative nutrition on surgical outcomes in patients with inflammatory bowel disease with vs without preoperative biologic therapy.

METHODS:

Seventy patients who had received biologic therapy within 8 weeks before undergoing resection for active ulcerative colitis (n = 34) or Crohn's disease (n = 36) were included (BIO group). The control group comprised 70 patients without exposure to biologics, selected based on 5 matching criteria: inflammatory bowel disease subtype (ulcerative colitis/Crohn's disease), age (≤ or >40 years), disease severity (moderate/severe), surgical approach (open/laparoscopic), and main surgical procedure. Poor nutrition was defined as the presence of at least one of the following criteria: weight loss >10%–15% within 6 months, body mass index <18.5 kg/m2, Subjective Global Assessment Grade C, or serum albumin <30 g/L.

RESULTS:

The proportion of patients with preoperative poor nutrition was 43% in the BIO and 33% in the control groups (P = 0.22). The incidence of postoperative infectious complications (anastomotic leak, intra-abdominal abscess, enterocutaneous fistula, or wound infection) was 16% in the BIO and 14% in the control groups (P = 0.81). In the BIO group, poor nutrition significantly increased the risk of infectious complications (27% vs 8% without poor nutrition, P = 0.03). In addition, in the control group, the incidence of infectious complications was higher in patients with poor nutrition, but not significantly (22% vs 11%, P = 0.21).

DISCUSSION:

Poor nutrition increases the risk of infectious complications after surgery. The detrimental effects of poor nutrition on postsurgical infection may be enhanced in patients who have received biologic therapy preoperatively.
Sepsis dan Tata Laksana Berdasar Guideline Terbaru
Authors: Irvan Irvan , Febyan Febyan , Suparto Suparto
Published: May 2019

Istilah Sepsis menurut konsensus terbaru adalah keadaan disfungsi organ yang mengancam jiwa yang disebabkan karena disregulasi respon tubuh terhadap infeksi. Penggunaan kriteria SIRS untuk mengidentifikasi sepsis dianggap tidak membantu lagi. Kriteria SIRS tidak menggambarkan adanya respon disregulasi yang mengancam jiwa. Disfungsi organ didiagnosis apabila peningkatan skor SOFA ≥ 2. Dan istilah sepsis berat sudah tidak digunakan. Septik syok didefinisikan sebagai keadaan sepsis dimana abnormalitas sirkulasi dan metabolik yang terjadi dapat menyebabkan kematian secara signifikan. Dalam protokol yang dikeluarkan pada tahun 2016, target resusitasi EGDT dihilangkan, dan merekomendasikan terapi cairan kristaloid minimal sebesar 30 ml/kgBB dalam 3 jam atau kurang.
KINERJA PELAYANAN PENGELOLAAN SAMPAH BERDASARKAN PENDAPAT PEDAGANG DAN PENGELOLA PASAR DI PASAR TALANG, KECAMATAAN GUNUNG TALANG KABUPATEN SOLOK
Authors: Susilawati Susilawati , Wahyono Hadi
Published: May 2019

Market waste is one waste generation from commercial areas that influence the municipal waste generation. Thus it is necessary to manage effectively and efficiently in order to be sustainable in environmental, social and economical. Talang market is one of the traditional markets in Solok Regency which has an area of ± 3.30 Ha, is the largest and most crowded market in Solok Regency. This market operates every Wednesday with 420 merchants. The problem is there is still a lot of waste disposed in the open air, not all of them be transported to landfill. In addition, there is still a lot of waste scattered in the corners of kiosks and market hallway after the market operates. The purpose of this study is to examine the performance and factors that influence the performance of waste management services based on the opinion of traders and market managers in Talang Market, Gunung Talang District, Solok Regency. This research uses descriptive statistical method with quantitative approach. Analyze technique is done by scoring and factor analysis with tangible variable, reliability, responsiveness, assurance, empathy, finance, social and environment with 208 respondents. The result of this research is the performance of waste management service of Talang Market has bad category with the score of 2.58 in range interval 2-2,667. The main factors affecting the performance are operational technical factors. Other important factors are financing factor and service quality, service effectiveness factor, individual role factor, personnel quality factor, service guarantee factor and waste minimization factor at source. Recommendation from the research that is in according with the main factors as well as the less and poor performance that is required optimization of transportation, transfer, collection, warehousing, the ability of personnel and increase the participation of individuals in waste management.
CO2 sequestration by carbonation of olivine: a new process for optimal separation of the solids produced
Authors: Turri Laura , Gérardin Karine , Muhr Hervé , Lapicque François , Saravia Alvaro , Szenknect Stéphanie , Mesbah Adel , Mastretta Régis , Dacheux Nicolas , Meyer Daniel , Cloteaux Anaëlle , Gérard Antoine , Bertucci Salvatore
Published: May 2019

CO2 sequestration by reaction with abundant, reactive minerals such as olivine has often been considered. The most straightforward, direct process consists in performing the reaction at high temperature and CO2 pressure, in view to producing silica, magnesium and iron carbonates and recovering the traces of nickel and chromite contained in the feedstock mineral. Most of direct processes were found to have an overall cost far larger than the CO2 removal tax, because of incomplete carbonation and insufficient properties of the reaction products. Similar conclusions could be drawn in a previous investigation with a tubular autoclave. An indirect process has been designed for high conversion of olivine and the production of separate, profitable products e.g. silica, carbonates, nickel salts, so that the overall process could be economically viable: the various steps of the process are described in the paper. Olivine particles (120 μm) can be converted at 81% with a low excess of acid within 3 h at 95°C. The silica quantitatively recovered exhibits a BET area over 400 m2 g-1, allowing valuable applications to be considered. Besides, the low contents of nickel cations could be separated from the magnesium-rich solution by ion exchange with a very high selectivity.
Multiculturalism, (Im)Migration, Theatre: The National Arts Centre, Ottawa, a Case of Staging Canadian Nationalism
Authors: Meerzon Yana
Published: May 2019

On October 22, 2015, two days after the Liberal Party of Canada came to power, The Globe and Mail published an editorial entitled “Canada to the World: Xenophobia Doesn’t Play Here.” The article suggested that, in these times of migration crises, a rising xenophobic discourse and neo-nationalism, it is essential for the European countries to start taking lessons in navigating cultural diversity from Canada, the first country in the world that institutionalized principles of multiculturalism. This view is clearly reflected in the repertoire politics of Canadian theatre institutions, specifically the National Arts Centre (NAC) Ottawa, the only theatre company in Canada directly subsidized by its government. Mandated to support artistic excellence through arts, the NAC acts as a pulpit of official ideology. It presents diversity on stage as the leading Canadian value, and thus fulfills its symbolic function to serve as a mirror to its nation.However, this paper argues that, by offering an image of Canada, constructed by our government and tourist agencies, as an idyllic place to negotiate our similarities and differences, the NAC fosters what Loren Kruger calls a theatrical nationhood (4–16). A closer look at the 2014 NAC English theatre co-production of Kim’s Convenience will help illustrate how the politics of mimicry can become a leading device in the aesthetics of national mimesis – a cultural activity of “representing the nation as well as the result of it (an image of the nation)” (Hurley 24); and how the artistry of a multicultural kitchen-sink can turn a subject of diversity into that of affirmation and sentimentalism.
The State We’re in: Violence and Working-Class Women on and off the Contemporary Irish Stage
Authors: Maguire Tom
Published: May 2019

This essay examines the ways in which women in the lowest socio-economic class are represented on the contemporary Irish stage. Its central concern is with the ways in which the Naturalistic dramatic representation of the home as a domestic sphere for poor women may confound nationalist discourses of the country as home, yet may fail to resist the systemic violence of the state against its most precarious citizens. To do so I set the actual economic conditions of these precarious women alongside social attitudes to poverty and the poor to demonstrate the systemic violence enacted on the most vulnerable. Turning then to dominant media representations, the essay questions the interaction between representation and reality more generally, whereby Ireland’s poorest are demonised and disenfranchised as figures of fun or fear in forms of representational violence. Against this broader backdrop, the paper identifies recurrent forms of and tropes in stage representations to raise questions about both the form and function of theatre for contemporary spectators, focusing on two contemporary plays Waiting on Ikea and Pineapple. For some, this promotes pleasures of recognition; for others the frisson of class voyeurism. The central argument is that little has changed since O'Casey put Juno Boyle and Bessie Burgess onstage – in either the precarious lives led by poor women, their representation on stage or the failures of the audiences or the state to accept responsibility for the unequal lives of Irish citizens.
Resource limitations and competitive interactions affect carnivore community composition at different ecological scales in a temperate island system
Authors: Allen Maximilian L. , Harris Rachel E. , Olson Lucas O. , Olson Erik R. , Van Stappen Julie , Van Deelen Timothy R.
Published: May 2019

Selective pressures (i.e. resource limitation and competitive interaction) that drive the composition of ecological communities vary, and often operate on different ecological scales (ecological variables across varying spatial scales) than observed patterns. We studied the drivers of distribution and abundance of the American marten (Martes americana) and the carnivore community at three ecological scales on a Great Lakes island archipelago using camera traps. We found different drivers appeared important at each ecological scale and studying any of the three scales alone would give a biased understanding of the process driving the system. Island biogeography (resource limitation) was most important for carnivore richness, with higher richness on larger islands and lower richness as distance from the mainland increased. Marten presence on individual islands appeared to be driven by island size (resource limitation) and human avoidance (competitive interaction). Marten abundance at camera trap sites was driven by the cascading effect of coyotes (Canis latrans) on fishers (Pekania pennanti) (competitive interaction). Incorporating three ecological scales gave novel insights into the varying effects of resource limitation and competitive interaction processes. Our data suggests that ecological communities are structured through multiple competing ecological forces, and effective management and conservation relies on our ability to understand ecological forces operating at multiple ecological scales.
Numerical Development and Evaluation of an Energy Conserving Conceptual Stochastic Climate Model
Authors: Gugole Federica , Franzke Christian L. E.
Published: May 2019

In this study we aim to present the successful development of an energy conserving conceptual stochastic climate model based on the inviscid 2-layer Quasi-Geostrophic (QG) equations. The stochastic terms have been systematically derived and introduced in such away that the total energy is conserved. In this proof of concept studywe give particular emphasis to the numerical aspects of energy conservation in a highdimensional complex stochastic system andwe analyzewhat kind of assumptions regarding the noise should be considered in order to obtain physical meaningful results. Our results show that the stochastic model conserves energy to an accuracy of about 0.5% of the total energy; this level of accuracy is not affected by the introduction of the noise, but is mainly due to the level of accuracy of the deterministic discretization of the QG model. Furthermore, our results demonstrate that spatially correlated noise is necessary for the conservation of energy and the preservation of important statistical properties, while using spatially uncorrelated noise violates energy conservation and gives unphysical results. A dynamically consistent spatial covariance structure is determined through Empirical Orthogonal Functions (EOFs). We find that only a small number of EOFs is needed to get good results with respect to energy conservation, autocorrelation functions, PDFs and eddy length scale when comparing a deterministic control simulation on a 512 × 512 grid to a stochastic simulation on a 128 × 128 grid. Our stochastic approach has the potential to seamlessly be implemented in comprehensive weather and climate prediction models.
An Assessment Method for Certified Environmental Sustainability in the Preservation of Historic Buildings. A Focus on Energy Efficiency and Indoor Environmental Quality in the Italian Experience of GBC Historic Building
Authors: Boarin P. , Lucchi E. , Zuppiroli M.
Published: May 2019

Environmental sustainability certification represents a strategic opportunity for improving energy efficiency, environmental quality, rational use of resources and design innovation in historic buildings, allowing greater transparency on energy uses and environmental management. To address these aspects, the Green Building Council of Italy has developed a new rating system, GBC Historic Building®, derived from the most diffused environmental sustainability assessment method worldwide (i. e. Leadership in Energy and Environmental Design - LEED®), in order to evaluate the sustainability level of restoration, rehabilitation and adaptation of historic buildings built before the end of World War II. This manuscript focuses on how this innovative assessment method addresses energy issues and indoor environmental quality aspects throughout the different thematic areas, introducing the new category “Historic Value”, distinctive of this protocol, aimed at improving the knowledge on the historic building and to support a sustainable approach in the restoration process.
Low-Load vs. High-Load Resistance Training to Failure on One Repetition Maximum Strength and Body Composition in Untrained Women
Authors: Dinyer Taylor K. , Byrd M. Travis , Garver Matthew J. , Rickard Alex J. , Miller William M. , Burns Steve , Clasey Jody L. , Bergstrom Haley C.
Published: May 2019

Dinyer, TK, Byrd, MT, Garver, MJ, Rickard, AJ, Miller, WM, Burns, S, Clasey, JL, and Bergstrom, HC. Low-load vs. high-load resistance training to failure on one repetition maximum strength and body composition in untrained women. J Strength Cond Res 33(7): 1737–1744, 2019—This study examined the effects of resistance training (RT) to failure at low and high loads on one repetition maximum (1RM) strength and body composition (bone- and fat-free mass [BFFM] and percent body fat [%BF]) in untrained women. Twenty-three untrained women (age: 21.2 ± 2.2 years; height: 167.1 ± 5.7 cm; body mass: 62.3 ± 16.2 kg) completed a 12-week RT to failure intervention at a low (30% 1RM) (n = 11) or high (80% 1RM) (n = 12) load. On weeks 1, 5, and 12, subjects completed 1RM testing for 4 different exercises (leg extension [LE], seated military press [SMP], leg curl [LC], and lat pull down [LPD]) and a dual-energy x-ray absorptiometry scan to assess body composition. During weeks 2–4 and 6–7, the subjects completed 2 sets to failure for each exercise. During weeks 8–11, the subjects completed 3 sets to failure for each exercise. The 1RM strength increased from week 1 to week 5 (LE: 18 ± 16%; SMP: 9 ± 11%; LC: 12 ± 22%; LPD: 13 ± 9%), week 1 to week 12 (LE: 32 ± 24%; SMP: 17 ± 14%; LC: 23 ± 26%; LPD: 25 ± 13%), and week 5 to week 12 (LE: 11 ± 9%; SMP: 7 ± 9%; LC: 10 ± 7%; LPD: 11 ± 11%) in each exercise, with no significant differences between groups. There were no significant changes in BFFM (p = 0.241) or %BF (p = 0.740) for either group. Resistance training to failure at 30% 1RM and 80% 1RM resulted in similar increases in 1RM strength, but no change in BFFM or %BF. Untrained women can increase 1RM strength during RT at low and high loads, if repetitions are taken to failure.