bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolution of Plasmodium vivax populations in border areas of the Greater Mekong Subregion during malaria elimination
Authors: Li Yuling , Hu Yubing , Zhao Yan , Wang Qinghui , Mbenda Huguette Gaelle Ngassa , Kittichai Veerayuth , Lawpoolsri Saranath , Sattabongkot Jetsumon , Menezes Lynette , Liu Xiaoming , Cui Liwang , Cao Yaming
Published: December 2019

BackgroundCountries within the Greater Mekong Subregion (GMS) of Southeast Asia have committed to eliminating malaria by 2030. Although malaria situation has greatly improved, Plasmodium vivax remains at international border regions. Therefore, to gain a better understanding of transmission dynamics, knowledge on the evolution of P. vivax populations after the scale-up of control interventions will guide more effective targeted control efforts. MethodsWe investigated genetic diversity and population structures in 206 longitudinally collected P. vivax clinical samples in two international border areas at the China-Myanmar border (CMB, n=50 in 2004 and n=52 in 2016) and western Thailand border (n=50 in 2012 and n=54 in 2015). Parasites were genotyped using 10 microsatellite markers. ResultsDespite intensified control efforts, genetic diversity in the four populations remained high (HE = 0.66-0.86). The proportions of polyclonal infections showed substantial decreases to 23.7 and 30.7% in the CMB and western Thailand, respectively, with corresponding decreases in the multiplicity of infection. Consistent with the shrinking map of malaria transmission in the GMS over time, there were also increases in multilocus linkage disequilibrium, suggesting of more fragmented and increasingly inbred parasite populations. There were considerable genetic differentiation and subdivision with the four tested populations. Various degrees of clustering were evident between the older parasite samples collected in 2004 at the CMB with the 2016 CMB and 2012 Thailand populations, suggesting some of these parasites had shared ancestry. In contrast, the 2015 Thailand population was genetically distinctive, which may reflect a process of population replacement. The moderately large effective population sizes and proportions of polyclonal infections highlight the necessity of further coordinated and integrated control efforts on both sides of the borders in the pursuit of malaria elimination. ConclusionsWith enhanced control efforts on malaria elimination, P. vivax population in the GMS has fragmented into a limited number of clustered foci, but the presence of large P. vivax reservoirs still sustains genetic diversity and transmission. These findings provide new insights into P. vivax transmission dynamics and population structure in this area.
Correlation of tumor necrosis factor-α -308G>A polymorphism with susceptibility, clinical manifestations and severity in Behçet syndrome: evidences from an Italian genetic case-control study
Authors: Padula Maria Carmela , Leccese Pietro , Lascaro Nancy , Radice Rosa Paola , Limongi Antonina Rita , Sorrento Giusi Gaia , Carbone Teresa , Padula Angela Anna , Martelli Giuseppe , D’Angelo Salvatore
Published: December 2019

Background The tumor necrosis factor (TNF)α is a multifunctional proinflammatory cytokine, implicated in a variety of diseases, including Behçet syndrome (BS), a rare vasculitis with a wide spectrum of clinical manifestations. The aim of the present study was to investigate the association between a functional drug-response TNFα gene polymorphism (at the positions of -308; rs1800629) and both disease susceptibility and clinical manifestations in a cohort of Italian BS patients compared with healthy controls (HC).Methods We recruited 130 Italian patients with BS consecutively seen at Rheumatology Institute of Lucania (Italy) and 100 ethnically, age and gender matched HC. Demographic and clinical features were retrieved by medical records. Specific primer pairs were designed for TNFα coverage. Genomic DNA isolation, primer-specific PCR amplification and direct sequencing were performed for genotyping our group of patients and controls. In silico analysis was downstream performed using Mutation Surveyor software (SoftGenetics, USA) and NCBI-BlastN on line tool for the query-subject similarity analysis.Results The genotype distribution of BS patients and HC underlined a higher percentage of wild-type GG genotype in BS patients group vs HC (106/130 patients, 81.5% vs 91/100 HC, 91%; p<0.05), while the heterozygous genotype (GA) was identified in 24/130 patients (18.5%) vs 9/100 HC (9%) (p<0.05). GA genotype was significantly associated with the disease (OR=2.29, 95% CI 1.01-5.18). No significant association was recognized between the SNP and the BS clinical manifestations, as well as with disease severity (Krause's index).Conclusions We found statistically significant higher frequency of TNFα rs1800629 GA genotype in patients than in controls. No significant association was recognized between the polymorphism and the clinical parameters, as well as between the SNP and the disease severity. Our data need to be confirmed in larger cohort of patients and matched controls.
Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-κb and p38 MAPK Signaling Pathways
Authors: Hu Xuantao , Ouyang Zhengxiao , Peng Dan , Yin Ziqing , Chen Xia , Jiang Guangyao , Yang Daishui , Cao Ziqin , Li Shuai , Liu Zicheng
Published: December 2019

Backgroud: Aseptic prosthetic loosening is one of main factor producing poor prognosis of limb function after joint replacement and requiring troublesome revision surgery. It is featured by wear particle–induced periprosthetic osteolysis mediated by excessive osteoclasts activated in inflammatory cell context. In our previous study, some natural compounds showing anti-osteoclast trait with high cost-efficiency and few side effects. Tussilagone (TUS), as the main functional extract from Tussilago Farfara precedently used for relieving cough, asthma and eliminating phlegm in traditional medicine, has been proved to appease several RAW264.7-mediated inflammatory diseases via suppressing osteoclast-related signaling cascades. However, whether and how TUS can improve aseptic prosthetic loosening via modulating osteoclast-mediated bone resorption still need to be answered. Methods: We established a murine calvarial osteolysis model to detect the preventative effect of TUS on osteolysis in vivo. Micro-CT scanning and histomorphometric analysis were used to determine the variation of bone resorption and osteoclastogenesis in samples. The anti-osteoclast-differentiation and anti-bone-resorption bioactivities of TUS in vitro were investigated using bone slice resorption pit evaluation and interference caused by cytotoxicity of TUS was excluded according to CCK-8 assay. Quantitative PCR analysis was applied to prove the decreased expression of osteoclast-specific genes after TUS treatment. The inhibition effect of TUS on NF-κb and p38 MAPK signaling pathways was testified by western blotting and NF-κB-linked luciferase reporter gene assay.Results: TUS demonstrated bone protective effect against osteolysis in murine calvarial osteolysis model with reduced osteoclasts compared to the control group. Following studies in vitro witnessed that TUS exert anti-osteoclastogenesis and anti-bone-resorption effects in both BMMs and RAW264.7 cells, as evidenced by the decline of osteoclast specific genes according to quantative PCR. Western blotting revealed that TUS-treated demonstrated inhibited IκBα degradation and p38 phosphorylation.Conclusions: Collectively, for the first time our studies prove that TUS inhibits osteoclastogenesis by suppressing the NF-κb and p38 MAPK signaling pathways, therefore serving as a potential natural compound to treat periprosthetic osteolysis-induced aseptic prosthetic loosening.
Characterization of Ethanol Producing Yeasts for Their Efficiency in Ethanol production, Salt Tolerance, and Utilization of Glucose and Xylose.
Authors: Joshi Jarina , Bhattarai Tribikram , Yadav Amar , Sreer Lakshmaiah
Published: December 2019

Yeast are the mainstay in ethanol production industry. Search for efficient yeast strains that are salt tolerant and utilize both hexoses (glucose) and pentoses (xylose and arabinose) is important in fermentation industry. In this regard,12 yeast strains, viz., CDBT1-12, were isolated from various sources and characterized. Molecular characterization of the yeast strains was done by sequencing 26S rRNA gene, D1D2 region. Out of 12 isolates, 10 were found to be Saccharomyces cerevisiae , CDBT7 was Wikerhamomyces anomalous , and CDBT8 was Cyberlindnera fabianii . The yeast isolates were characterized in terms of their ethanol production efficiency, salt tolerance and ability to utilize of glucose and xylose. All the strains were found to be good ethanol producers. Yeast strain CDBT2 was found to have tolerance for high salt (up to 15%) and ethanol (up to 16%) concentrations. Yeast strain CDBT7 was found to utilize both glucose and xylose without compromising on ethanol production efficiency. The CDBT7 strain was also salt tolerant (up to15%).Yeast strain CDBT2 when grown in an electrochemical cell with low levels of applied external voltage, alcohol dehydrogenase (ADH1) and pyruvate decarboxylase (PDC1) mRNA levels were increased by 2.78 ± 0.80 and 1.12 ± 0.37 fold, respectively. We believe, the latter observation is novel and it has not been reported previously. It also further supports our previous observation of increase in level of alcohol production by CDBT2 strain in the presence of applied electrical current.
Human disease-related pathways increasing with opportunistic pathogens bloom in intestinal microbiome after vancomycin exposure and restoration with fecal transplantation by simulator of the human intestinal microbial ecosystem (SHIME)
Authors: Liu Lei , Wang Qing , Qi Hongmei , Das Ranjit , Lin Huai , Shi Jingliang , Wang Siyi , Yang Jing , Xue Yingang , Mao Daqing , Luo Yi
Published: December 2019

Background: Antibiotics are growing reported to cause human intestinal microbial disorders with increasing abundances of opportunistic pathogens, and fecal microbiota transplantation (FMT) has been confirmed to restore the dysbiosis of gut flora in many kinds of intestinal disease. However, to date, few studies have focused on the bloomed opportunistic pathogens associated human disease-related pathways as well as antibiotic resistance genes (ARGs) after vancomycin exposure, and there is limited information on using FMT for restoration of intestinal microbiome affected by antibiotics. Methods: This study investigated effects of vancomycin on the opportunistic pathogens, human disease-related pathways as well as ARGs in human gut, and the restoration of intestinal microbiome by FMT. Using the simulator of the human intestinal microbial ecosystem (SHIME), two reactors (representing the ascending and descending colon, respectively) were inoculated with human intestinal microbiota from a healthy adult volunteer who did not suffer from gastrointestinal diseases or take any antibiotic in the previous six months. Samples were collected from the reactors at six-time points (before treatment, after seven days of individual 10 mg/L, 100 mg/L, 1000 mg/L vancomycin treatment, 14 days following the termination of vancomycin and 14 days following FMT). The intestinal microbiome composition and function were analyzed using 16S rRNA gene sequencing and High-throughput Quantitative PCR (HT-qPCR).Results: Vancomycin treatment substantially increased human disease-related pathways and decreased abundances of ARGs. Besides, the bloomed opportunistic pathogens including Achromobacter, Klebsiella, and Pseudomonas, caused by vancomycin exposure, were positively correlated with human disease-related pathways. The microbiota abundance and genes of human disease-related pathways and antibiotic resistance showed a remarkable return towards baseline after FMT, but not for natural recovery. Conclusions: These findings suggest that impacts of vancomycin on human gut are profound and FMT will be a promising strategy in clinical application that can restore the dysbiosis of gut microbiota, which may be valuable for directing future work.
Estratégia cirúrgica para tratamento de adenoma pleomórfico de grande tamanho: relato de caso
Authors: Fernandes Breno dos Reis , Marchirori Darah Ligia , Belloti Neto Oswaldo , Bella Patrese Pereira de , Mulinari dos Santos Gabriel , Cenci Raphael , Sassi Luana Carolina , Coléte Juliana Zorzi
Published: December 2019

As neoplasias da glândula parótida constituem um grupo heterogêneo com mais de 30 tipos histológicos definidos, sendo o adenoma pleomórfico o tumor benigno mais comum. Neste artigo é relatado um caso clínico onde o tumor apresentou evolução de um ano, sem sintomatologia associada, gerando assimetria facial ao paciente, sendo realizado tratamento cirúrgico conservador apenas por enucleação da lesão, visando reduzir cirurgias maiores como a parotidectomias parciais ou totais. Após acompanhamento de 5 anos o paciente não apresenta sequelas do tratamento cirúrgico, nem sinal de recorrência da lesão.Descritores: Adenoma Pleomorfo; Glândula Parótida; Relatos de Casos.ReferênciasSeifert G, Sobin L. Histological typing of salivary gland tumors. World Health Organization. International histological classification of tumors, 2.ed. Berlin: Springer-Verlag; 1991.Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2807 patients. Head Neck Surg. 1986; 8(3):177-84Witt RL. The significance of the margin in parotid surgery for pleomorphic adenoma. Laryngoscope 2002; 112(12):2141-54Louro RS, Passeado D, Andrade MC, Sampaio RKPL. Adenoma pleomórfico em palato duro: relato de caso clínico. Rev Bras Odontol. 2002;59(1):25-7.Nogueira AS, Alves APNN, Nogueira RAS, Tavares RN. Adenoma pleomórfico no palato duro: relato de caso clínico. Rev Paul Odontol. 2001;23(1):14-8.Ribeiro-Rotta RF, Cruz Ml, Paiva RR, Mendonça EF, Spini TH, Mendonça AR. O papel da ressonância magnética no diagnóstico do adenoma pleomórfico: revisão da literatura e relato de casos. Rev Bras Otorrinolaringol. 2003;69(5):699-707.van der Wal JE, Leverstein H, Snow GB, Kraaijenhagen HA, van der Waal I. Parotid gland tumors: histologic reevaluation and reclassification of 478 cases. Head Neck. 1998; 20(3):204-7.Cohen MA. Pleomorphic adenoma of the cheek. Int J Oral Maxillofac Surg. 1986; 15(6):777-9.Tiago RSL, Castro GA, Ricardo LAC, Biihler RB, Fava AS. Adenoma pleomórfico de parótida: aspectos clínicos, diagnósticos e terapêuticos. Rev Bras Otorrinolaringol. 2003;69(4):485-89.Kamal SA, Othman EO. Diagnosis and treatment of parotid tumours. J Laringol Otol. 1997; 111(4):316-21Nogueira AS, Alves APNN, Nogueira RAS, Tavares RN. Adenoma pleomórfico no palato duro: relato de caso clínico. Rev Paul Odontol. 2001;23(1):14-8Neville BW, Damm DD, Allen CM, Bouquot JE. Patologia oral e maxilofacial. 2. ed. Rio de Janeiro: Guanabara Koogan; 2004.
MOTIVAÇÃO POPULACIONAL PARA PARTICIPAÇÃO EM UM PROGRAMA DE COLETA SELETIVA
Authors: Feitosa Anny Kariny , Barden Júlia Elisabete
Published: December 2019

Este artigo simula a implantação de um programa de coleta seletiva na cidade de Juazeiro do Norte, Estado do Ceará, no nordeste brasileiro. O objetivo é identificar os fatores que estimulariam a participação da população em um programa de coleta seletiva, caso fosse implementado. O estudo consistiu de duas etapas: na primeira, foram entrevistados 360 munícipes entre os meses de novembro de 2016 a fevereiro de 2017. Os dados coletados foram analisados, através da análise de conteúdo temático-categorial para identificar as categorias principais de motivação para a população pesquisada participar do programa de coleta seletiva. Posteriormente, estimou-se o coeficiente de correlação phi (rφ) para identificar as variáveis motivacionais associadas à participação na coleta seletiva, bem como o coeficiente de Spearman (ρ) para analisar a associação com variáveis socioeconômicas. Como resultados, observou-se que 84,44% dos respondentes admitiram que participariam da coleta seletiva. De acordo com o coeficiente de correlação phi (rφ), a variável participação na coleta seletiva está mais associada à preocupação com a preservação do meio ambiente. Referindo-se às variáveis socioeconômicas, com base no coeficiente de Spearman (ρ), apesar da fraca correlação positiva, foi possível identificar que a maior intenção de participação no programa está associada a população com maiores níveis de escolaridade.
Unidades de Conservação no Ceará: análise dos usos legais da Área de Relevante Interesse Ecológico do Sítio Curió, Fortaleza/CE
Authors: Cabral Nájila Rejanne Alencar Julião , Silva Doris Day Santos
Published: December 2019

A Área de Relevante Interesse Ecológico (ARIE) é um tipo de área protegida e se constitui em uma das categorias de Unidades de Conservação previstas no Sistema Nacional de Unidades de Conservação da Natureza. A citada categoria tem por finalidade regular o uso admissível dessas áreas, em consonância com outros objetivos da conservação da natureza e de uso do solo daquela área. Dentre as áreas protegidas existentes no território cearense, tem-se a ARIE Sítio Curió, criada em 2006 por ato do poder executivo estadual. Este trabalho tem por objetivo analisar os usos legais praticados no âmbito da ARIE do Sítio Curió, no período de 2007 a 2015. A metodologia utilizada seguiu adaptação da matriz de conformidade adotada por McHarg (1969). A matriz de conformidade de McHarg (1969) permite identificar a compatibilidade dos diferentes usos do solo com os determinantes naturais. Na adaptação metodológica desse trabalho as atividades proibidas e permitidas por lei foram usadas como base para a elaboração da matriz de compatibilidade. Os resultados apontaram que a maioria das atividades realizadas na ARIE do Sítio Curió, no período de avaliação, era compatível com os usos legais previstos para aquela área protegida, o que pode auxiliar os objetivos de proteção e de manejo da unidade de conservação analisada
ADIÇÃO DE QUITOSANA EM FISHBURGER: CARACTERÍSTICAS MICROBIOLÓGICAS, SENSORIAIS E DE COCÇÃO
Authors: Pinto Farias Mirla Dayanny , Aragão Ambrósio Larissa Ster , Vieira Rayane Martins , Frota Menezes Layana Mary , César Leiliane Teles
Published: December 2019

Pescados são alimentos de alto valor nutricional com fácil digestão e estão associados a diminuição da incidência de doenças crônicas, seu consumo pode ser intensificado através da oferta de produtos derivados, como o fishburger. Portanto, o presente trabalho objetivou avaliar por pesquisa experimental, as características microbiologias, sensoriais e de cocção de fishburger de tilápia adicionado de quitosana como substituinte da gordura. Os fishburgers foram elaborados a partir de filés de tilápia fresca obtidos no mercado local e transportados em gelo até a área de processamento, seguindo das etapas de sanitização, trituração, homogeneização dos ingredientes, modelagem manual e divisão em duas formulações: Hc (controle – 0% de quitosana) e Hq (substituição total de gordura por gel de quitosana). Os fishburgers foram submetidos a analises microbiológicas (coliformes totais, termotolerantes e Salmonella sp.), análise sensorial e testes de cocção. Os resultados microbiológicos das formulações (Hc e Hq) encontraram-se dentro do determinado pela legislação, observando-se ausência de qualquer contaminação ou resistência microbiológica após cocção. Além disso, as características sensoriais não foram influenciadas pela inclusão de quitosana, entretanto, todos os resultados de cocção demonstraram-se distintos entre as formulações, resultado caracterizado pela diminuição da capacidade de reter água do produto após a adição da quitosana e exclusão da gordura. A aplicação de quitosana em fishburger de tilápia como substituta da gordura modificou suas características de cocção, porém, não interferiu nas características sensoriais e microbiológicas, tornando sua aplicação viável.
Elaboração e Caracterização de Mousse de Siriguela (Spondias Purpurea) Adicionado de Pólen Apícola
Authors: Chastinet Braga Renata , Lima Monteiro Lorena Ligia de , Bezerra do Nascimento Kivia Kelly , Rabelo e Silva Flannia Marla , Fernandes Lima Ariosvana
Published: December 2019

O mercado de alimentos funcionais no Brasil vem crescendo, porém ainda é mínimo quando comparados a países como Japão e estados Unidos. Há a necessidade da criação de outros produtos inovadores, capazes de agregar valor nutricional a partir de suas propriedades funcionais, tendo em vista a crescente demanda por esses produtos no mercado atual. O objetivo deste trabalho é elaborar e caracterizar a mousse de siriguela adicionado de pólen apícola visando a criação de um produto funcional. Foi feito um trabalho experimental de elaboração de formulações de mousse de siriguela com diferentes concentrações de pólen apícola. Foram feitos a composição centesimal, avaliações físico-químicas de PH, Vitamina C, acidez e compostos fenólicos e o perfil de textura. Os resultados demonstraram alto teor de umidade (70,43 a 71,20) e caboidratos (20,62 a 21,36) e teores de proteina de 1,83 a 2,43%, lipídios 4,83 a 5,45, e cinzas de 0,90 a 0,92%. Sem variações significativas para o valor calórico. Os resultados de compostos fenólicos e vitamina C indicaram que a adição do pólen apícola promoveu o aumentos dos composto bioativos. Com relação ao perfil de texturas a coesividade e mastigabilidade apresentação mudanças significativas, portanto conclui-se que a adição do pólen apícola a mousse gera um produto com potencial de alimento funcional pela presença de composto fenólicos e vitamina C, mas são necessários teste sensoriais de aceitação, principalmente ligadas aos aspectos textura e sabor para que ele seja disponibilizado para o mercado.
Soil Properties and Mineral Nutrients of Clementine Mandarine (Citrus reticulata Blanco) Grown in the Koycegiz Region of Mugla Province
Authors: YILDIZTEKİN Mahmut , KUZU Semir
Published: December 2019

Soil properties of
the samples from orchards and the nutrients (macro- and microelements) in the
clementine mandarin (Citrus reticulata
Blanco), widely grown in the Köyceğiz region of Muğla Province Turkey, were
studied. Mandarin tree leaves and soil samples were collected from 10 different
orchards. The soil samples were analyzed for its pH, CaCO3, EC,
sand, organic matter, nitrogen (N), phosphorus (P), potassium (K), calcium
(Ca), magnesium (Mg), iron (Fe), zinc (Zn), manganese (Mn), copper (Cu) and
boron (B) while leaves were analyzed for its macro- and microelements. The
results obtained from soil analysis showed suitable amount of calcium carbonate
and EC. Analysis of the soil showed that organic matter, N, K and Mn were
insufficient in all orchards, while Fe was higher in amount. Slight alkaline,
strong alkaline and neutral pHs were determined in the orchards. Besides, the
leaf samples collected from the orchards reflected deficient amount of N and Ca
while higher amount of Mg and Fe.
Klasifikasi Citra Alat Musik Tradisional dengan Metode k-Nearest Neighbor, Random Forest, dan Support Vector Machine
Authors: Sujaini Herry
Published: December 2019

Dalam dekade terakhir, metode non-parametrik (algoritma berbasis pembelajaran mesin) semakin banyak dipergunakan dari berbagai aplikasi berbasis pengolahan citra digital. Penelitian ini bertujuan untuk membandingkan tiga metode non-parametrik yaitu Metode k-Nearest Neighbor (kNN), Random Forest (RF), dan Support Vector Machine (SVM) terhadap klasifikasi citra alat musik tradisional di Indonesia yang populer di kalangan masyarakat yaitu : angklung, djembe, gamelan, gong, gordang, kendang, kolintang, rebana, sasando, dan serunai. Dari hasil eksperimen pengklasifikasian dengan metode kNN, RF dan SVM, metode kNN memiliki akurasi yang paling baik. Rata-rata nilai precision ketiga metode tersebut berturut-turut adalah 92,1% untuk kNN, 85,4% untuk SVM, dan 69,4% untuk RF
TÜRK HUKUKUNDA YERİNE GETİRİLMİŞ BAĞIŞLAMANIN GERİ ALINMASI VE BGB. 313. ÇERÇEVESİNDE ALMAN FEDERAL YÜKSEK MAHKEME KARARININ DÜŞÜNDÜRDÜKLERİ
Authors: YILMAZ Çiğdem Mine
Published: December 2019

Bağışlama sözleşmesinin, sözleşme
taraflarından sadece bağışlayana borç yükleyen bir sözleşme olması sebebiyle
6098 sayılı Türk Borçlar Kanunu’muzda, bağışlayanı ve onun malvarlığını
korumaya yönelik düzenlemeler öngörülmüştür . Bu sözleşme ile bağışlanan, yani
kendisine değer kazandırılan kişinin zenginleştirilmesi amacı güdülmektedir.
Çalışmada, Türk hukukunda yapılan bağışlamanın geri istenebilmesi için
bağışlamaya özgü sebepler ve bağışlama dışında hangi hukuki kurumlara
başvurulabileceği Alman Medeni Kanunu, Burgerliches Gesetzbuch’da (BGB) yer
alan “işlem münasebeti esası”nın felsefesine de değinilerek açıklanmaya ve
önerilerde bulunulmaya çalışılacaktır. Alman Federal Yüksek Mahkemesi,
Bundesgerichtshof’un, (BGH) yerleşik içtihat hukuku uyarınca, evliliğe ilişkin
bağışlama durumu, eşlerden birinin diğerine bir mal varlığını evlilikten dolayı
ve evlilikle hayat birliğinin gerçekleştirilmesi ve oluşturulması, muhafaza
edilmesi veya güvence altına alınması maksadıyla vermesi, bununla evlilik yaşam
birliğinin var olmasını ve bu birliktelik dâhilinde verdiği bu mal varlığından
ve onun getirilerinden istifade etmeye devam etme düşüncesi veya beklentisi
içinde olmasıyla mevcut olur. Bağışlamanın, münasebet esası burada yatmaktadır.
Ne var ki, eşlerin yasal mal rejimi çerçevesinde, evlilikten dolayı bağışlama
halleri durumu mevcutsa iade işlemlerinin - bir mal ayrılığı rejiminin mevcut
olmasından farklı olarak –  BGB. Art. 313
uyarınca halledilmesi bir istisnadır. Federal Mahkemeye göre, kazanç
denkleştirmesi gerçekleştirilir ve yalnızca bunun uygun olmayan bir sonuca yol
açması durumunda BGB. Art. 313. uyarınca bir iade işlemi düşünülebilir.
Prof. Dr. Zeki HAFIZOĞULLARI
Authors: HAFIZOĞULLARI Zeki
Published: December 2019

Otobiyografi
Boundary condition identification of a clamped honeycomb sandwich panel based on thin-layer element
Authors: Xu Yu , Cao Zhifu , Jiang Dong
Published: December 2019

The stiffness of boundary conditions in mechanical structures is difficult to represent. An approach on high fidelity modeling of the clamped boundary condition is proposed in this paper. Firstly, the normal and tangential stiffness of the contact surface of the clamped boundary condition is parameterized by using thin-layer element with isotropic material. Secondly, the material parameter is identified by minimizing the discrepancy between the calculated results and the experimental data, and parameter identification can be treated as an optimization problem. Experimental investigation is undertaken to verify the proposed method by employing an aluminum honeycomb panel, the numerical model of which is constructed by using the equivalent theory. Thin-layer elements with different properties are used to simulate the mechanical properties in different area of the boundary conditions, and the experimental modal data is adopted to identify the material parameters. Results show that the weighted matrix is a crucial option in the parameter identification procedure, and the width to thickness ratio of the thin layer element has a great influence on the identification results. After parameter identification, the error of the first three order of the modal frequencies is less than 2.7 %, the thin-layer element can accurately reflect the mechanical performance of clamped boundary condition.
Performance of PID-Fuzzy control for cab isolation mounts of soil compactors
Authors: Nguyen Vanliem , Jiao Renqiang , Le Vanquynh , Hoang Anhtan
Published: December 2019

To improve the soil compactor ride comfort, a combined control method of Fuzzy and PID control is proposed to control the cab isolation system of soil compactor based on the non-linear vehicle dynamic model. The vibration excitation sources are concerned by the vibrator drum and elastoplastic soil (EPS) interactions in the compression process. The power-spectral-density (PSD) and weighted root-mean-square (RMS) of acceleration responses of both the vertical driver’s seat and pitching cab angle are chosen as the objective functions. The research results show that both the PSD and weighted RMS values of the vertical driver’s seat and pitching cab angle are significantly reduced by using the PID-Fuzzy control under various EPSs in the low-frequency region, especially on the EPS with high-density.
Pedagogical Correction of Reading Phobia in Primary School Pupils: Methodical and Neurophysiological Aspects
Authors: Proskuryakova L. A. , Nalimova T. A.
Published: December 2019

The research featured the phenomenon of the so-called reading phobia, which is characterized by an irrational obsessive fear of reading that interferes with the normal psycho-emotional development of the child, thus affecting their entire life. The paper introduces a new method of pedagogical correction of reading phobia in children of primary school age. The experiment involved six first-graders (four boys and two girls). They received correctional 40-minute classes twice a week for 3–6 months, depending on the complexity of each particular case of reading phobia. The authors developed six consecutive teaching methods: teamwork of the teacher, the psychologist, and the parents in a friendly atmosphere; face-toface work with the child; use of specially selected texts and methods of involving the child in the reading process; individual approach to the duration of classes, etc. The paper focuses on the neurophysiological characteristics and etiology of reading phobia. Reading phobia is described as a fear of reading instilled by adults, which often affects primary schoolers. The article also contains a list of negative effects of mental development and socialization that children with reading phobia are bound to face if they receive no special therapy. The developed method can be used by primary school teachers and psychologists.
Adaptation Dynamics of the First-Year Students to the Educational Environment of the Medical University
Authors: Chizhkova M. B.
Published: December 2019

The paper features the changes that take place in the process of adaptation of first-year students to the educational environment of the medical university during the first year of study. The methods research included diagnostic tools and methods of data processing, e.g. T.D. Dubowitzka and A. V. Krylova's technique "Adaptation of students at the university", questionnaire "Student Anxiety" in J. Taylor’s modification, φ-Fisher conversion multifunctional criterion and t-Student parametric criterion for dependent samples. A statistical analysis made it possible to make certain conclusions about the ambiguous nature of the dynamics of adaptation of freshmen to the educational environment of the medical university. The identified reliable differences in the indicators of adaptation to learning activity make significant additions to the scientific perception on the leading role of the given adaptation type, which has an open, pronounced, but fleeting positive character. The absence of significant differences in anxiety rates at the beginning and end of the school year indicates a fairly stable emotional background, with a predominance of average and elevated levels. On the other hand, certain aspects in the educational environment of the university cause persistent negative experience. The emotional state of the respondents by the end of the first year revealed a new aspect of anxiety, i. e. interpersonal relationships within the grouр. The authors believe this is due to the change of orientation in the adaptation process. The change reflects the formation of a community of freshmen with actively flowing processes of status differentiation and the transformation of a diffuse group into a prosocial association. This transformation suggests a different kind of adaptation dynamics to student grouр. This longer and more latent kind of adaptation is determined by intragroup processes.
Concept "Star" in English Linguaculture: Notional Features
Authors: Bakirova A. A.
Published: December 2019

The article describes the notional features of the concept of star in the English worldview and focuses on those specifics of the representation of the concept that reveal the national consciousness of native English speakers. To describe the structure of the concept, the author analyzed dictionary articles, idioms, and synonyms. The analysis revealed 17 notional signs: a natural luminous body visible in the sky at night; a fixed point of light in the sky; hot balls of burning gas that emits its own light; a planet; fortune / destiny; horoscope; a celebrity; the main person in a film / play; an outstandingly successful person or thing in a group; an object or shape; a figure; a sign of rank / position; a star-shaped ornament or medal worn as a badge of honor or authority; classification of hotels; a white patch on the forehead of a horse or other animal; starfish; a sign of asterisk. The cognitive attributes "stellar body", "fortune / destiny", and "a white patch on the forehead of a horse or other animal" proved to go back to motivating features, which indicates their long-term presence in the language. However, a study of co-occurrence indicated relatively recent cognitive features. Examples were taken from classical English literature and the British National Corpus. A comparative analysis of the actualization of the meanings of the representative word in sentences showed that its conceptual features coincide with the data of explanatory dictionaries.
Flaubert’s Semicolon in English Translations of "Madame Bovary"
Authors: Karapets V. V.
Published: December 2019

The paper considers the peculiarities of translation of such a stylistic feature in G. Flaubert’s novel "Madame Bovary" as a semicolon. The research featured extracts from six English translations and focused on the use of semicolons in complex sentences in position between clauses without conjunction and before et. The continuous sampling method and the comparative method were employed to detect and analyze the punctuation mark and its use. The research objective was to verify whether the author’s punctuation was translated and to what extent. The analysis of the corpus shows that, despite some individual preferences, translators respected isomorphism in punctuation in the great majority of cases, i.e. they used semicolon and equivalent conjunctions. Isomorphism’s percentage appeared higher than in Russian translations, which was possibly due to the fact that English punctuation system has more in common with the French than with the Russian one. The degree of fidelity can possibly be explained by the strategies used by a particular translator rather than by the contemporary punctuation tendencies. The results of this research can be used in preparation of multilingual corpora of parallel texts, as well as in textbooks on comparative grammar and syntax.
A. R . Rosenberg: "the Doctors’ Plot" in Stalinsk State Institute of Advanced Medical Training (1953)
Authors: Genina E. S. , Kaymashnikova E. B.
Published: December 2019

This research reconstructed the biography of Professor A. R. Rosenberg, MD, who was the first head of the Microbiology Department of Stalinsk State Institute of Advanced Medical Training (the modern city of Novokuznetsk) in 1951–1953. The paper focuses on the prosecution this scientist and educator who suffered from the so-called "Doctors’ plot" (1953). "The Doctors' plot" is regarded as the final event of the anti-cosmopolitanism campaign of 1949–1953, which was directed primarily against the Jewish intellectuals. The campaign was notorious for the severe attacks on the academia. At the Stalinsk Institute, they launched a "purge" based on the ethnic principle, which resulted in a criminal case against some employees, including A. R. Rosenberg. The arrested educators were declared "members of the Jewish-bourgeois nationalist group". The charges brought were connected with the ideological principles of the campaign against cosmopolitanism and "the Doctors’ plot". After the criminal case was terminated, A. R. Rosenberg was reinstated in his position. However, poor health made him retire in 1953. A. R. Rosenberg shared the fate of the Soviet intelligentsia who suffered during the campaign against cosmopolitanism and "the Doctors’ plot".
The Role of Educational and Demonstration Workshops in the Development of Vocational Education and Training for the Handicraft Industry of Tomsk Province in the Early XX Century
Authors: Ovchinnikov V. A.
Published: December 2019

The present research featured educational and demonstration handicraft workshops in the Tomsk Province in the early XX century. The research objective was to determine the general course and features of the workshops that played a significant role in the modernization of technology and handicrafts in the region, along with other institutions of the Tomsk State Handicraft Committee, e.g. museums, warehouses, and libraries. The workshops became an important part of vocational education. A major role on the state level belonged to the administration of land management and agriculture and the Imperial Russian technical society. In the Tomsk province it belonged to the Tomsk Provincial Handicraft Committee and the Tomsk Department of the Russian Technical Society. By 1917, seventeen settlements in six parishes of the Province had seventeen workshops in nine areas of handicraft industry. Weaving, wagon-making, and agricultural engineering workshops predominated. They became centers for the development of vocational education and the popularization of new technologies. They organized educational support workshops for the adult population, sold modern machinery and materials, built warehouses for handicrafts and repair shops, instructor schools, etc. The network of workshops, along with vocational educational institutions, became the basis for the Soviet system of vocational education in Siberia in the post-revolutionary period. The paper contains an analysis of researches and historical sources. The results helped to fill the gaps in the history of vocational education in the South of Western Siberia.
Personal and Ethnic Identity in Students: a Cross-Cultural Comparison
Authors: Bokhan T. G. , Shabalovskaya M. V. , Borodich J. V. , Terekhina O. V. , Ulyanich A. L.
Published: December 2019

The research featured a cross-cultural comparison of personal and ethnic identity in university students in the conditions of multicultural educational environment. The study involved 141 students: 48 Russians, 45 students from various European countries, and 48 Chinese students. The psychodiagnostic research methods included the questionnaire "Who Am I?" by M. Kuhn and T. McPartland as modified by T. V. Rumyantseva and the questionnaire "Types of ethnic identity" by G. U. Soldatova, S. V. Ryzhova. The research revealed common and specific features of personal and ethnic identity of each group. The importance of reflection and identification of one’s own educational and professional role position were present in the structure of personal identity of every group. As for the structure of ethnic identity, all groups demonstrated an increased level of positive ethnic identity and an average level of ethnic indifference. In the content of personal identity of Russian students, the Social Self (profession, family), the Perspective Self, and the Reflective Self were more pronounced in contrast with other groups. The European students showed a greater manifestation of ethnic nihilism. The Chinese students demonstrated a greater hyperidentity. In each test group, the authors established two types that differed in the specifics of the relationship between personal and ethnic identity. The results can improve the psychological support of students in the process of their self-identification in the conditions of multicultural educational environment.
Identity Threats in the System of Attitudes to Personal Security
Authors: Ivanov M. S.
Published: December 2019

The study made an attempt to approach the problem of identity threats from the perspective of modern security psychology, which studies psychological attitude to personal security as a systemic phenomenon. Threats to one’s personal security in the subject's view were analyzed in terms of threats to one’s identity. The representative sample (n=50, age=22) underwent a correlation analysis to identify the relationships between the assessments of individual threats to personal security and elements of identity, i.e. subjective evaluations of positive and negative personal qualities. Negative elements of identity appeared to be the most vulnerable, e.g. "depressed". The same was true for positive elements that are more dependent on external conditions and assessments, e.g. "happy", "generous", etc. As for self-reliant and assessments, e.g. "hardworking", "disciplined", they proved more secured. The subject’s perceptions of oneself and one’s security threats were in complex mutual determinations. Threats to personal security became threats to identity if implementation of these threats led to a deterioration in the subject's self-image.
Happy Family Representation: a Cross-Cultural Analysis of Russian and Mongolian Youth
Authors: Oyunsuren J. , Yermolaev V. V.
Published: December 2019

This paper presents an empirical study of representations of Russian and Mongolian youth about a happy family. The research featured 120 young Russian and Mongolian people (age: 18–30). The results were obtained using Charles Osgood’s semantic differential method, Sacks and Levy’s sentence completion test, and various questionnaires. Factorial, cluster, and qualitative analyses were used to process the results. The study revealed some ethnic and gender differences regarding the concept of "happy family". Russian and Mongolian youth appear to follow different ideal models. For Mongolian youth, a happy family was a "large family" and "parental family". For Russian women, a happy family was one with few children, while for Russian men demonstrated opposite views. Therefore, in contrast to Mongolia, the family institution in Russia is developing modern ideas about a happy family life. Mongolian youth use their parents’ family as a model to follow, while Russian young people follow the role models promoted by the media. However, the romantic ideas about marriage were quite similar in both groups.
PROBLEMS AND PROSPECTS OF DEVELOPMENT OF RURAL TOURISM IN THE REPUBLIC OF KARELIA
Authors: Maksimova Valentina Ivanovna
Published: December 2019

The article touches upon the problems that prevent the development of rural tourism in the region in full, reveals some pressing issues on the prospects for the development of rural tourism and teaches the main directions of their solution.
Mesleki Tükenmişlik, Makyevelizm, Psikolojik Sözleşme İhlali ve Demokratik Liderlik Arasındaki İlişkilerin Smartpls ile Analizi
Authors: Yasım Yavuz Kağan
Published: December 2019

Bu çalışmanın amacı, satış elemanlarının mesleki tükenmişlik, makyevelistlik, psikolojik sözleşme ihlali algısı ve liderlerinin demokratiklik düzeyi arasındaki ilişkileri incelemektir. Satış hedefleri ile çalışan personelin örgütsel tutumları, örgüt hedeflerine ulaşmada önemli bir kriterdir. Çalışmanın evrenini hızlı tüketim sektöründe çalışan satış personeli oluşturmaktadır. Bu amaçla Ankara’da çalışan 148 satış elemanına anket uygulanmıştır. Anket verileri SmartPLS programı ile analiz edilmiştir. Gerekli koşulları taşımayan anket soruları elenerek analiz dışında tutulmuştur. Analiz sonucunda ahlaki yoksunluk ile psikolojik sözleşme ihlali ve liderin demokratiklik düzeyi arasında; statü arzusu ile psikolojik sözleşme ihlali algısı arasında; kontrol arzusu ile psikolojik sözleşme ihlali, liderin demokratikliği ve kişisel başarısızlık hissi arasında anlamlı bir ilişki bulunamamıştır. Bazı değişkenler arasında ise farklı yönde ve farklı büyüklükte anlamlı ilişkiler olduğu görülmüştür.
The Influence of Different Spacers on Biological Profile of Peptide Radiopharmaceuticals for Diagnosis and Therapy of Human Cancers
Authors: Farahani Arezou M. , Maleki Fariba , Sadeghzadeh Nourollah
Published: December 2019

Background:

Cancer is the leading cause of death worldwide. Early detection can reduce the disadvantageous
effects of diseases and the mortality in cancer. Nuclear medicine is a powerful tool that has the ability
to diagnose malignancy without harming normal tissues. In recent years, radiolabeled peptides have been
investigated as potent agents for cancer detection. Therefore, it is necessary to modify radiopeptides in order to
achieve more effective agents.

Objective:

This review describes modifications in the structure of radioconjugates with spacers who have improved
the specificity and sensitivity of the peptides that are used in oncologic diagnosis and therapy.

Methods:

To improve the biological activity, researchers have conjugated these peptide analogs to different
spacers and bifunctional chelators. Many spacers of different kinds, such as hydrocarbon chain, amino acid
sequence, and poly (ethyleneglycol) were introduced in order to modify the pharmacokinetic properties of these
biomolecules.

Results:

Different spacers have been applied to develop radiolabeled peptides as potential tracers in nuclear
medicine. Spacers with different charge and hydrophilicity affect the characteristics of peptide conjugate. For
example, the complex with uncharged and hydrophobic spacers leads to increased liver uptake, while the composition
with positively charged spacers results in high kidney retention. Therefore, the pharmacokinetics of
radio complexes correlates to the structure and total charge of the conjugates.

Conclusion:

Radio imaging technology has been successfully applied to detect a tumor in the earliest stage. For
this purpose, the assessment of useful agents to diagnose the lesion is necessary. Developing peptide radiopharmaceuticals
using spacers can improve in vitro and in vivo behavior of radiotracers leading to better noninvasive
detection and monitoring of tumor growth.
opinião pública duvida da opinião publicada
Authors: Shuen Li-Chang , Bentivi Zefinha
Published: December 2019

Neste trabalho, apresentamos parte dos resultados da pesquisa Observatório de Mídia e Eleições 2018 no Maranhão. Catalogamos e analisamos as notícias publicadas durante a pré-campanha e o período eleitoral nos principais veículos de mídia do estado, nos três suportes: televisão, rádio AM e jornal impresso. Os veículos escolhidos são os de maior audiência e/ou visibilidade em seus segmentos e cobrem os dois lados do espectro ideológico-partidário regional: mídia alinhada ao grupo da candidata Roseana Sarney e mídia alinhada ao governador Flávio Dino. Além do acompanhamento das notícias, o Observatório realizou uma pesquisa de opinião sobre a percepção do eleitorado a respeito da cobertura desses veículos em dois colégios eleitorais: São Luís e Raposa.