bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors involved in picky eating in children with disabilities visiting outpatient clinics to receive feeding therapy
Authors: Tanaka Yuko , Matsuyama Miwa , Tamura Fumiyo , Mizukami Miki , Tanaka Kumi , Kikutani Takeshi
Published: July 2024

This study aimed to clarify the factors influencing picky eating in children with disabilities based on the hypothesis that primary disease or oral function is involved in picky eating. The subjects were 242 children aged 3–6 years receiving outpatient feeding therapy at our clinic. The subjects’ general and oral conditions and picky eating were assessed by their medical recodes. Resultingly, 79 children showed picky eating. Using logistic regression analysis, associated factors of picky eating were primary disease (p = .04), nutritional methods (p = .01), and oral hypersensitivity (p = .04). The relationship with the primary disease suggests the influence of the characteristics of the primary disease. The relationship with oral hypersensitivity may be attributed to avoiding certain sensations. Additionally, the study revealed that the subjects employed tube feeding to compensate for reduced nutritional intake due to picky eating. This study indicated that primary disease and nutritional method as general conditions and oral hypersensitivity as an oral function were possible factors for picky eating. Picky eating was found to occur at varying frequencies depending on the underlying primary disease, especially when the child struggled to tolerate different sensations experienced during meals.
Money talks? The motivational mechanisms of base pay on well‐being and work performance
Authors: Olafsen Anja H. , Jauvin Florence , Cécire Pascale , Forest Jacques
Published: July 2024

Whether compensation serves as a motivational resource for employees is still a debated subject. It has been suggested that the effect of pay on motivation could be contingent on the satisfaction of the basic psychological needs as outlined by self‐determination theory. The current research explored the role of amount of base pay as well as pay fairness discrepancy in relation to basic psychological need satisfaction, autonomous work motivation and, in turn, psychological well‐being (i.e., vigor and emotional exhaustion), turnover intentions, and work performance. Managerial need support was also included in the model, so its mechanisms and its effects on the outcomes could be measured against those of pay. Using a combination of archival data and employees' self‐reports from 593 Norwegian workers, results revealed that amount of base pay did not predict satisfaction of any of the basic needs, pay fairness discrepancy negatively predicted satisfaction of the needs for autonomy and relatedness and positively predicted satisfaction of the need for competence, whereas managerial need support significantly predicted satisfaction of all three needs. While there was no significant direct relation from amount of base pay to any of the outcomes, results showed a significant direct relation from managerial need support to psychological well‐being (positive to vigor and negative to emotional exhaustion) and turnover intentions (negative). There was also a significant direct positive relation from pay fairness discrepancy to turnover intentions.
Fabrication, Modeling, and Testing of a Prototype Thermal Energy Storage Containment
Authors: Gifford Jeffrey , Davenport Patrick , Wang Xingchao , Ma Zhiwen
Published: July 2024

Increasing penetration of variable renewable energy resources requires the deployment of energy storage at a range of durations. Long-duration energy storage (LDES) technologies will fulfill the need to firm variable renewable energy resource output year round; lithium-ion batteries are uneconomical at these durations. Thermal energy storage (TES) is one promising technology for LDES applications because of its siting flexibility and ease of scaling. Particle-based TES systems use low-cost solid particles that have higher temperature limits than the molten salts used in traditional concentrated solar power systems. A key component in particle-based TES systems is the containment silo for the high-temperature (>1100 ∘C) particles. This study combined experimental testing and computational modeling methods to design and characterize the performance of a particle containment silo for LDES applications. A laboratory-scale silo prototype was built and validated the congruent transient finite element analysis (FEA) model. The performance of a commercial-scale silo was then characterized using the validated model. The commercial-scale model predicted a storage efficiency above 95% after 5 days of storage with a design storage temperature of 1200 ∘C. Insulation material and concrete temperature limits were considered as well. The validation of the methodology means the FEA model can simulate a range of scenarios for future applications. This work supports the development of a promising LDES technology with implications for grid-scale electrical energy storage, but also for thermal energy storage for industrial process heating applications.
Numerical Calculation of the Oil Flow in a Truck Rear Axle Transmission and the Influence of Gear-Induced Air Flow
Authors: Hildebrand Lucas , Beierer Philipp , Lohner Thomas , Stahl Karsten
Published: July 2024

For the reliable operation of a gearbox, consistently sufficient lubrication of machine elements is necessary. Thus, the gearbox fluid flow plays an important role. The state of the art indicates that computational fluid dynamics (CFD) enables targeted support of the gearbox development process at an early stage. Computational time plays a prominent role in practical applications. The particle-based smoothed particle hydrodynamics (SPH) shows great potential for time-efficient calculations, especially with a simplified single-phase modeling approach. This study first examines the influence of gear-induced air flow on gearbox oil flow, focusing on a test gearbox to identify a suitable modeling approach for a truck rear axle transmission. The results indicate that the gear-induced air flow mainly impacts gearbox oil flow at higher circumferential speeds. For lower circumferential speeds, a single-phase model yields good results with significantly reduced computation times compared to a two-phase model. Applying the single-phase model to the truck rear axle transmission and comparing numerical results with experimental findings demonstrates a reliable representation of the oil flow characteristics.
A Data-Driven Approach for Forecasting Current Direction With a Hybrid Model of Empirical Mode Decomposition and Warped Gaussian Process
Authors: Liao Xiang , Wei Kai , Yang Qingshan
Published: July 2024

Ocean current forecasting is essential for tidal renewable energy generation and operation. However, forecasting the current direction at multiple points along the water depth are still lacking of comprehensive studies. In this study, a data-driven approach was developed to attain short-term prediction in the current direction with reasonable uncertainty quantification. The developed approach employed empirical mode decomposition (EMD) and the warped Gaussian process (WGP) in the forecasting process. The ocean current data, which were measured by a seabed-mounted acoustic Doppler current profiler in the Haitian Strait, were used to illustrate the developed approach. The measured current direction data were preprocessed with the average shifting method to obtain the principal and random components for the improvement of the forecasting accuracy. The random components were decomposed into intrinsic mode functions (IMFs) and residuals. The principal components, IMFs, and residuals of the current direction were then forecasted by the WGP approach. The forecasting performance of the developed approach was investigated through comparisons with those of single standard GP, single WGP, and EMD + GP models. The effects of the kernel function and training input on the forecasting efficiency and precision were investigated. The extrapolation performances of the proposed model for a 1-step prediction and multistep-ahead prediction were also examined.
Multiple factors trigger the formation and resuscitation of the VBNC state in alcohol-producing
Klebsiella pneumoniae
Authors: Zhao Shuo , Dou Chenpu , Zhang Jian , Huang Lijuan , Gao Yagang , Du Bing , Cui Xiaohu , Zhao Hanqing , Xue Guanhua , Ke Yuehua , Gan Lin , Feng Junxia , Feng Yanling , Cui Jinghua , Yan Chao , Xu Ziying , Fu Tongtong , Yu Zihui , Yang Yang , Yuan Jing , You Fuping
Published: July 2024

Klebsiella pneumoniae
can enter a viable but nonculturable (VBNC) state to survive in unfavorable environments. Our research found that high-, medium-, and low-alcohol-producing
K. pneumoniae
strains are associated with nonalcoholic fatty liver disease. However, the presence of the three
Kpn
strains has not been reported in the VBNC state or during resuscitation. In this study, the effects of different strains, salt concentrations, oxygen concentrations, temperatures, and nutrients in
K. pneumoniae
VBNC state were evaluated. The results showed that high-alcohol-producing
K. pneumoniae
induced a slower VBNC state than medium-alcohol-producing
K. pneumoniae
, and low-alcohol-producing
K. pneumoniae
. A high-salt concentration and micro-oxygen environment accelerated the loss of culturability. Simultaneously, both real-time quantitative PCR and droplet digital PCR were developed to compare the quantitative comparison of three
Kpn
strain VBNC states by counting single-copy gene numbers. At 22°C or 37°C, the number of culturable cells decreased significantly from about 10
8
to 10
5
–10
6
CFU/mL. In addition, imipenem, ciprofloxacin, polymyxin, and phiW14 inhibited cell resuscitation but could not kill VBNC-state cells. These results revealed that the different environments evaluated play different roles in the VBNC induction process, and new effective strategies for eliminating VBNC-state cells need to be further studied. These findings provide a better understanding of VBNC-state occurrence, maintenance, detection, and absolute quantification, as well as metabolic studies of resuscitation resistance and ethanol production.

IMPORTANCE

Bacteria may enter VBNC state under different harsh environments. Pathogenic VBNC bacteria cells in clinical and environmental samples pose a potential threat to public health because cells cannot be found by routine culture. The alcohol-producing
Kpn
VBNC state was not reported, and the influencing factors were unknown. The formation and recovery of VBNC state is a complete bacterial escape process. We evaluated the influence of multiple induction conditions on the formation of VBNC state and recovery from antibiotic and bacteriophage inhibition, and established a sensitive molecular method to enumerate the VBNC cells single-copy gene. The method can improve the sensitivity of pathogen detection in clinical, food, and environmental contamination monitoring, and outbreak warning. The study of the formation and recovery of VBNC-state cells under different stress environments will also promote the microbiological research on the development, adaptation, and resuscitation in VBNC-state ecology.
Metagenome-derived SusD-homologs affiliated with Bacteroidota bind to synthetic polymers
Authors: Silverio Myllena Pereira , Neumann Tabea , Schaubruch Kirsten , Heermann Ralf , Pérez-García Pablo , Chow Jennifer , Streit Wolfgang R.
Published: July 2024

S
tarch
u
tilization
s
ystem (Sus)D-homologs are well known for their carbohydrate-binding capabilities and are part of the
sus
operon in microorganisms affiliated with the phylum Bacteroidota. Until now, SusD-like proteins have been characterized regarding their affinity toward natural polymers. In this study, three metagenomic SusD homologs (designated SusD1, SusD38489, and SusD70111) were identified and tested with respect to binding to natural and non-natural polymers. SusD1 and SusD38489 are cellulose-binding modules, while SusD70111 preferentially binds chitin. Employing translational fusion proteins with superfolder GFP (sfGFP), pull-down assays, and surface plasmon resonance (SPR) has provided evidence for binding to polyethylene terephthalate (PET) and other synthetic polymers. Structural analysis suggested that a Trp triad might be involved in protein adsorption. Mutation of these residues to Ala resulted in an impaired adsorption to microcrystalline cellulose (MC), but not so to PET and other synthetic polymers. We believe that the characterized SusDs, alongside the methods and considerations presented in this work, will aid further research regarding bioremediation of plastics.

IMPORTANCE

SusD1 and SusD38489 can be considered for further applications regarding their putative adsorption toward fossil-fuel based polymers. This is the first time that SusD homologs from the polysaccharide utilization loci (PUL), largely described for the phylum Bacteroidota, are characterized as synthetic polymer-binding proteins.
α-Hemolysin-mediated endothelial injury contributes to the development of
Staphylococcus aureus
-induced dermonecrosis
Authors: Yang Ching , Robledo-Avila Frank H. , Partida-Sanchez Santiago , Montgomery Christopher P.
Published: July 2024

Staphylococcus aureus
α-hemolysin (Hla) is a pore-forming toxin critical for the pathogenesis of skin and soft tissue infections, which causes the pathognomonic lesion of cutaneous necrosis (dermonecrosis) in mouse models. To determine the mechanism by which dermonecrosis develops during
S. aureus
skin infection, mice were given control serum, Hla-neutralizing antiserum, or an inhibitor of Hla receptor [A-disintegrin and metalloprotease 10 (ADAM10) inhibitor] followed by subcutaneous infection by
S. aureus,
and the lesions were evaluated using immunohistochemistry and immunofluorescence. Hla induced apoptosis in the vascular endothelium at 6 hours post-infection (hpi), followed by apoptosis in keratinocytes at 24 hpi. The loss of vascular endothelial (VE)-cadherin expression preceded the loss of epithelial-cadherin expression. Hla also induced hypoxia in the keratinocytes at 24 hpi following vascular injury. Treatment with Hla-neutralizing antibody or ADAM10 inhibitor attenuated early cleavage of VE-cadherin, cutaneous hypoxia, and dermonecrosis. These findings suggest that Hla-mediated vascular injury with cutaneous hypoxia underlies the pathogenesis of
S. aureus
-induced dermonecrosis.
When less is more: the art of communicating clinical microbiology results
Authors: Buchan Blake W.
Published: July 2024

The clinical microbiology laboratory is capable of identifying microorganisms in clinical specimens faster and more accurately than ever before. At face value, this should enable patient care providers to make better-informed decisions and target antimicrobial therapies to deliver individualized care. Ironically, more complete and specific reporting of microorganisms isolated from specimens may result in overtreatment based on the presence of a pathogen, even in the absence of clear signs of clinical infection. This conundrum calls into question the role of the laboratory in contributing to care through selective or “exception” reporting whereby some results are selectively withheld when there is a low probability that laboratory findings correlate with the clinical infection. In a recent article published in the
Journal of Clinical Microbiology
, Bloomfield et al. (J Clin Microbiol 62:e00342-24, 2024,
https://doi.org/10.1128/jcm.00342-24
) examine the impact and safety of an exception reporting strategy applied to wound swab specimens. Canonical pathogens associated with skin and soft tissue infections including
S. aureus
and beta-hemolytic streptococci are withheld from the laboratory report if certain patient criteria are met that would put them at low risk of adverse outcomes if untreated, or if treated with guideline-recommended empiric therapy. Their central finding was an approximately 50% reduction in post-laboratory report antibiotic initiation without adverse events or increased 30-day admission rate (indicative of infection-related complications, e.g., disseminated disease). While effectively achieving their goal, the premise of exception reporting and other modified reporting strategies raises questions about the potential risk of underreporting and how to ensure that the message is being interpreted, and acted upon, by care providers as was intended by the laboratory.
The complete genomic sequence of the type strain
Brochothrix thermosphacta
DSM 20171 highlights a diversity of prophages in this species
Authors: Gingras Loic , Piché Laurie C. , Saucier Linda , Vincent Antony T.
Published: July 2024

The bacterium
Brochothrix thermosphacta
is a known muscle food spoiler. Here, the complete genome sequence of the
B. thermosphacta
type strain, DSM 20171, is reported. Prediction of prophages and genomic islands reveals an unsuspected diversity in this bacterial species that deserves further investigation.
Shaping school for childhood myopia: the association between floor area ratio of school environment and myopia in China
Authors: Zeng Danqi , Yang Yahan , Tang Yang , Zhao Lanqin , Wang Xun , Yun Dongyuan , Chen Wenben , Shang Yuanjun , Xu Andi , Liao Huipeng , Zhang Xingying , Lin Duoru , Lin Haotian
Published: July 2024

Aim

To investigate the association of floor area ratio (FAR), an indicator of built environments, and myopia onset.

Methods

This prospective cohort study recruited 136 753 children aged 6–10 years from 108 schools in Shenzhen, China at baseline (2016–2017). Refractive power was measured with non-cycloplegic autorefraction over a 2-year follow-up period. FAR was objectively evaluated using geographical information system technology. Mixed-effects logistic regression models were constructed to examine the association of FAR with a 2-year cumulative incidence of myopia among individuals without baseline myopia; multiple linear regression model, with a 2-year cumulative incidence rate of myopia at each school.

Results

Of 101 624 non-myopic children (56.3% boys; mean (SE) age, 7.657±1.182 years) included in the study, 26 391 (26.0%) of them developed myopia after 2 years. In the individual-level analysis adjusting for demographic, socioeconomic and greenness factors, an IQR in FAR was associated with a decreased risk of 2-year myopia incidence (OR 0.898, 95% CI 0.866 to 0.932, p<0.001). Similar findings were observed in the analysis additionally adjusted for genetic and behavioural factors (OR 0.821, 95% CI 0.766 to 0.880, p<0.001). In the school-level, an IQR increase in FAR was found to be associated with a 2.0% reduction in the 2-year incidence rate of myopia (95% CI 1.3% to 2.6%, p<0.001).

Conclusions

Exposure to higher FAR was associated with a decreased myopia incidence, providing insights into myopia prevention through school built environments in China.
Effects of vitamin D and L-cysteine cosupplementation on circulating bioavailable and total 25-hydroxy-vitamin D, the free/total testosterone ratio and inflammatory biomarkers in healthy vitamin D-deficient African Americans: a placebo-controlled double-blind clinical trial
Authors: Jain Sushil K , Justin Margret Jeffrey , Zachary Alonzo , Lally Marissa M , Vanchiere John A , Mhanna Maroun J , Shi Runhua , Levine Steven N
Published: July 2024

Background

Subjects with metabolic syndrome and obesity have higher levels of inflammation with depression of the vitamin D (VD) hydroxylase/metabolising genes (CYP2R1/CYP27A1/CYP27B1/VDR) required to convert VD consumed in the diet into 25(OH)VD. Compared with total 25(OH)VD levels, measurement of bioavailable 25(OH)VD is a better method to determine the beneficial effect of VD.

Objective

This study investigates whether cosupplementation with VD and L-cysteine (LC), which downregulates inflammation and upregulates VD-regulating genes, provides a better therapeutic benefit than supplementation with VD-alone in African Americans (AA).

Methods

AA participants (men/women, aged 18–65 years; n=165) were block randomised into one of four groups and received daily, oral supplementation for 6 months with placebo, LC (1000 mg/day), VD (2000 IU/day) or VD+LC. Fasting blood collected at the baseline and final visits was analysed for total, free and bioavailable 25(OH)VD along with insulin, VD-binding protein (VDBP), sex hormone-binding globulin (SHBG), free and total testosterone, and inflammatory marker levels. Studies were carried out in THP-1 monocytes to elucidate the direct effect of LC and testosterone on VD-regulating genes.

Results

Baseline data showed no differences in age, body mass index, calcium, liver or kidney function among the groups. Compared with levels in the group that received VD-alone supplementation, levels of neutrophil-to-lymphocyte ratio, C reactive protein, HOMA-IR, VDBP and HbA1c were significantly lower in the VD+LC group while the VD+LC group showed a significant increase in bioavailable 25(OH)VD in both sexes, total 25(OH)VD levels were significantly elevated in men but not in women treated with VD+LC. Blood levels of SHBG and free/total testosterone were elevated in the VD+LC group but not in the VD-alone group. LC and testosterone treatment significantly upregulated VD-metabolising genes (CYP2R1/CYP27A1/CYP27B1/VDR) andSHBGin THP-1 monocytes.

Conclusions

VD cosupplemented with LC upregulates circulating bioavailable 25(OH)VD and reduces inflammation. Total 25(OH)VD levels were higher in men but not in women in the VD+LC group. This pilot study suggests that compared with supplementation with VD-alone, VD+LC cosupplementation could be a better approach to raising the total 25(OH)VD in men and the bioavailable 25(OH)VD in both sexes and lowering the inflammatory risk in the AA population.

Trial registration number

NCT04939792.
Disclosing the undisclosed: are radiographers and healthcare scientists required to communicate a provisional diagnosis when asked?
Authors: Pruski Michal , Rodger Daniel , Hurford James E
Published: July 2024

Patients need to be given the relevant information to be able to give informed consent, which might require the disclosure of a provisional diagnosis. Yet, there is no duty to give information to a patient if that patient is aware that this information exists but chooses not to request it. Diagnostic radiographers and healthcare scientists are often responsible for ensuring that patients have given informed consent for the investigations they undertake, but which were requested by other clinicians. Here we examine if they have a duty to disclose a patient’s provisional diagnosis made by a referring clinician if the patient asks for this information as part of the informed consent process to a diagnostic investigation. We first consider aspects of UK law, professional guidance and salient ethical principles, emphasising that while professional codes of practice highlight the need to act in the patient’s best interest, they do not require giving patients information they do not require for the examination or have not requested. We then propose that diagnostic radiographers and healthcare scientists placed in such a position use a ‘minimally necessary disclosure’ framework. This framework fulfils their commitment to their patient and the principle of veracity, while respecting the boundaries of their professional duties. The framework ensures that enough detail is given to the patient for them to be able to give informed consent, while shouldering the diagnostic professional from making a full disclosure, which is the duty of the referring clinician.
High-resolution laser spectroscopy on the hyperfine structure and isotope shift of $$^{237,239}$$Np
Authors: Kaja Magdalena , Urquiza-González Mitzi , Berg Felix , Reich Tobias , Stemmler Matou , Studer Dominik , Weber Felix , Wendt Klaus
Published: July 2024

Nuclear ground state properties of $$^{237,239}$$

237
,
239

Np were investigated by high-resolution laser spectroscopy at the RISIKO mass separator off-line radioactive beam facility of the University of Mainz. The isotope shifts and the hyperfine parameters were determined in two different atomic ground-state transitions at 398.80 nm and 395.61 nm. The data allowed for calculation of the so far unknown nuclear moments of the short-lived isotope $$^{239}$$

239

Np, i.e. the nuclear magnetic dipole moment of $$\mu _I$$

μ
I

= +3.18(2) $$\mu _N$$

μ
N

and the electric quadrupole moment of $$Q_S$$

Q
S

 = +4.05(8) eb, using the known nuclear moments of $$^{237}$$

237

Np as a reference, which were determined by electron paramagnetic resonance and investigations of muonic X-ray hyperfine structures, respectively.
Multi-Unitary Complex Hadamard Matrices
Authors: Bruzda Wojciech , Rajchel-Mieldzioć Grzegorz , Życzkowski Karol
Published: July 2024

We analyze the set of real and complex Hadamard matrices with additional symmetry constrains. In particular, we link the problem of existence of maximally entangled multipartite states of [Formula: see text] subsystems with [Formula: see text] levels each to the set of complex Hadamard matrices of order [Formula: see text]. To this end, we investigate possible subsets of such matrices which are, dual, strongly dual ([Formula: see text] or [Formula: see text]), two-unitary ([Formula: see text] and [Formula: see text] are unitary), or [Formula: see text]-unitary. Here [Formula: see text] denotes reshuffling of a matrix [Formula: see text] describing a bipartite system, and [Formula: see text] its partial transpose. Such matrices find several applications in quantum many-body theory, tensor networks and classification of multipartite quantum entanglement and imply a broad class of analytically solvable quantum models in [Formula: see text] dimensions.
Local Detailed Balance Invariant States of Markov Generators of Low Density Limit
Authors: García-Corte J. C. , Guerrero-Poblete F. , Quezada R.
Published: July 2024

We introduce the notion of local detailed balance for low density limit generators of quantum Markov semigroups and explore the consequences of this condition on the structure of the corresponding set of invariant states. The local detailed balance condition allows us to include the case of degenerate reference Hamiltonian and due to this degeneracy, we can compute nonequilibrium invariant states by combining the local detailed balance with generic, quasi-generic and [Formula: see text]-generic conditions, obtaining LDL Markov generators with pure invariant states.
A Study of Noise Effect in Feedback Control with White Noise Analysis
Authors: Takahash Taihei , Watanabe Noboru
Published: July 2024

In proportional-integral-derivative (PID) control, it is well known that the selection of a method to deal with noise is an important issue and various methods have been proposed. However, similar methods to determine the response to noise have not been studied in probability theory. In this paper, a new method called “weak form” is proposed and a probabilistic analysis of filtered derivatives is performed using this method. The method discussed in this paper is considered effective when it is not a feedback control.
Visualizing Progress in Broadening Participation in Computing: The Value of Context
Authors: Barr Valerie , Brodley Carla E. , Pérez-Quiñones Manuel
Published: July 2024

To improve diversity and BPC analysis and assessment, institutions should examine cohort-based data, report intersectional data as a norm, and consider university demographic context.
Agile C-states: A Core C-state Architecture for Latency Critical Applications Optimizing both Transition and Cold-Start Latency
Authors: Antoniou Georgia , Bartolini Davide , Volos Haris , Kleanthous Marios , Wang Zhe , Kalaitzidis Kleovoulos , Rollet Tom , Li Ziwei , Mutlu Onur , Sazeides Yiannakis , Haj Yahya Jawad
Published: July 2024

Latency-critical applications running in modern datacenters exhibit irregular request arrival patterns and are implemented using multiple services with strict latency requirements (30–250μs). These characteristics render existing energy-saving idle CPU sleep states ineffective due to the performance overhead caused by the state’s transition latency. Besides the state transition latency, another important contributor to the performance overhead of sleep states is the cold-start latency, or in other words, the time required to warm up the microarchitectural state (e.g., cache contents, branch predictor metadata) that is flushed or discarded when transitioning to a lower-power state. Both the transition latency and cold-start latency can be particularly detrimental to the performance of latency critical applications with short execution times. While prior work focuses on mitigating the effects of transition and cold-start latency by optimizing request scheduling, in this work we propose a redesign of the core C-state architecture for latency-critical applications. In particular, we introduce C6Awarm, a new Agile core C-state that drastically reduces the performance overhead caused by idle sleep state transition latency and cold-start latency while maintaining significant energy savings. C6Awarm achieves its goals by (1) implementing medium-grained power gating, (2) preserving the microarchitectural state of the core, and (3) keeping the clock generator and PLL active and locked. Our analysis for a set of microservices based on an Intel Skylake server shows that C6Awarm manages to reduce the energy consumption by up to 70% with limited performance degradation (at most 2%).
A Systematic Mapping Study Exploring Quantification Approaches to Code, Design, and Architecture Technical Debt
Authors: Perera Judith , Tempero Ewan , Tu Yu-Cheng , Blincoe Kelly
Published: July 2024

To effectively manage Technical Debt (TD), we need reliable means to quantify it. We conducted a Systematic Mapping Study (SMS) where we identified 39 quantification approaches for Code, Design, and Architecture TD. We analyzed concepts and metrics discussed in these quantification approaches by classifying the quantification approaches based on a set of abstract TD Quantification (TDQ) concepts and their high-level themes, process/time, cost, benefit, probability, and priority, which we developed during our SMS. This helped identify gaps in the literature and to propose future research directions. Among the abstract TDQ concepts discussed in the different quantification approaches, TD item, TD remediation cost, TD interest, and Benefit of remediating TD were the most frequently discussed concepts. They were also supported by some form of measurement. However, some TDQ concepts were poorly examined, for example, the benefit of taking TD. It was evident that cost concepts were more frequently quantified among the approaches, while benefit concepts were not. Most of the approaches focused on remediating TD in retrospect rather than quantifying TD to strategically use it during software development. This raises the question of whether existing approaches reliably quantify TD and suggests the need to further explore TDQ.
Computing the Heaviest Conflict-free Sub-DAG in DAG-based DLTs
Authors: Bramas Quentin
Published: July 2024

In this article, we consider DAG-based distributed ledger technologies (DLTs), i.e., DLTs where each block can reference several previous blocks hence forming a directed acyclic graph of blocks (BDAG). Each block has a weight (usually a constant normalized to one) and our goal is to compute the heaviest sub-BDAG that does not contain conflicting blocks.

First, we prove that computing such a sub-BDAG is NP-complete. Then, we show that the difficulty comes from concurrent conflicts and we present an optimal algorithm that is polynomial if the number of concurrent conflicts is bounded. We also give an efficient incremental version of our algorithm. Finally, we evaluate the performance of our algorithm on random BDAGs against an existing algorithm called GHOSTDAG and show that, in addition to being optimal, our algorithm is also more efficient in practice.
Phenomenology of Intermediate Molecular Dynamics at Metal-Oxide Interfaces
Authors: Cuk Tanja
Published: July 2024

Reaction intermediates buried within a solid-liquid interface are difficult targets for physiochemical measurements. They are inherently molecular and locally dynamic, while their surroundings are extended by a periodic lattice on one side and the solvent dielectric on the other. Challenges compound on a metal-oxide surface of varied sites and especially so at its aqueous interface of many prominent reactions. Recently, phenomenological theory coupled with optical spectroscopy has become a more prominent tool for isolating the intermediates and their molecular dynamics. The following article reviews three examples of the SrTiO3-aqueous interface subject to the oxygen evolution from water: reaction-dependent component analyses of time-resolved intermediates, a Fano resonance of a mode at the metal-oxide–water interface, and reaction isotherms of metastable intermediates. The phenomenology uses parameters to encase what is unknown at a microscopic level to then circumscribe the clear and macroscopically tuned trends seen in the spectroscopic data.
3D Nanocrystallography and the Imperfect Molecular Lattice
Authors: Vlahakis Niko , Holton James , Sauter Nicholas K. , Ercius Peter , Brewster Aaron S. , Rodriguez Jose A.
Published: July 2024

Crystallographic analysis relies on the scattering of quanta from arrays of atoms that populate a repeating lattice. While large crystals built of lattices that appear ideal are sought after by crystallographers, imperfections are the norm for molecular crystals. Additionally, advanced X-ray and electron diffraction techniques, used for crystallography, have opened the possibility of interrogating micro- and nanoscale crystals, with edges only millions or even thousands of molecules long. These crystals exist in a size regime that approximates the lower bounds for traditional models of crystal nonuniformity and imperfection. Accordingly, data generated by diffraction from both X-rays and electrons show increased complexity and are more challenging to conventionally model. New approaches in serial crystallography and spatially resolved electron diffraction mapping are changing this paradigm by better accounting for variability within and between crystals. The intersection of these methods presents an opportunity for a more comprehensive understanding of the structure and properties of nanocrystalline materials.
Enhancing the diagnostic yield of esophageal manometry using distension-contraction plots of peristalsis and artificial intelligence
Authors: Zifan Ali , Lee Ji Min , Mittal Ravinder K.
Published: July 2024

Our findings underscore the superiority of distension features over contraction metrics in diagnosing esophageal dysfunctions. By leveraging state-of-the-art machine learning techniques, our study highlights the diagnostic potential of distension-contraction plots of peristalsis. Implementation of these plots could significantly enhance the accuracy of identifying patients with esophageal motor disorders, advocating for their adoption as the standard in clinical practice.
Revitalizing gut barrier integrity: role of miR-192-5p in enhancing autophagy via Rictor in enteritis
Authors: Qiu Peishan , Zhou Kezhi , Wang Youwei , Chen Xiaoyu , Xiao Cong , Li Wenjie , Chen Yuhua , Chang Ying , Liu Jing , Zhou Feng , Wang Xiaobing , Shang Jian , Liu Lan , Qiu Zhao
Published: July 2024

We uncover the pivotal role of miR-192-5p in fortifying intestinal barriers amidst inflammation. Reduced miR-192-5p levels correlated with compromised gut integrity during inflammation. Notably, boosting miR-192-5p reversed gut damage by enhancing autophagy via suppressing Rictor, offering a potential therapeutic strategy for fortifying the intestinal barrier and alleviating inflammation in patients with enteritis.
Sulfasalazine‐Induced Epstein–Barr Virus‐Positive Mucocutaneous Ulcer
Authors: Stabel Cedric , Woei-A-Jin F. J. Sherida H. , Tousseyn Thomas , Garmyn Maria
Published: July 2024

Epstein–Barr virus (EBV) may cause a wide spectrum of symptomatology in humans ranging from asymptomatic upper respiratory tract infection to infectious mononucleosis and in more severe cases lymphoproliferative disorders or hemophagocytic lymphohistiocytosis. Its neoplastic potential is higher in immunocompromised individuals. We describe a case of EBV‐positive mucocutaneous ulcer, a more indolent clinical entity on the spectrum of EBV‐driven lymphoproliferative disorders, and are one of the first to put sulfasalazine, an immunomodulatory agent, forward as the possible culprit.
Figure S7 from CD106 in Tumor-Specific Exhausted CD8+ T Cells Mediates Immunosuppression by Inhibiting TCR Signaling
Authors: Naoi Yuto , Morinaga Takao , Nagasaki Joji , Ariyasu Ryo , Ueda Youki , Yamashita Kazuo , Zhou Wenhao , Kawashima Shusuke , Kawase Katsushige , Honobe-Tabuchi Akiko , Ohnuma Takehiro , Kawamura Tatsuyoshi , Umeda Yoshiyasu , Kawahara Yu , Nakamura Yasuhiro , Kiniwa Yukiko , Yamasaki Osamu , Fukushima Satoshi , Kawazu Masahito , Suzuki Yutaka , Nishikawa Hiroyoshi , Hanazawa Toyoyuki , Ando Mizuo , Inozume Takashi , Togashi Yosuke
Published: July 2024

Additional in vivo data.
Figure S4 from CD106 in Tumor-Specific Exhausted CD8+ T Cells Mediates Immunosuppression by Inhibiting TCR Signaling
Authors: Naoi Yuto , Morinaga Takao , Nagasaki Joji , Ariyasu Ryo , Ueda Youki , Yamashita Kazuo , Zhou Wenhao , Kawashima Shusuke , Kawase Katsushige , Honobe-Tabuchi Akiko , Ohnuma Takehiro , Kawamura Tatsuyoshi , Umeda Yoshiyasu , Kawahara Yu , Nakamura Yasuhiro , Kiniwa Yukiko , Yamasaki Osamu , Fukushima Satoshi , Kawazu Masahito , Suzuki Yutaka , Nishikawa Hiroyoshi , Hanazawa Toyoyuki , Ando Mizuo , Inozume Takashi , Togashi Yosuke
Published: July 2024

Additional CD106 expression data in PBMCs
Figure S3 from CD106 in Tumor-Specific Exhausted CD8+ T Cells Mediates Immunosuppression by Inhibiting TCR Signaling
Authors: Naoi Yuto , Morinaga Takao , Nagasaki Joji , Ariyasu Ryo , Ueda Youki , Yamashita Kazuo , Zhou Wenhao , Kawashima Shusuke , Kawase Katsushige , Honobe-Tabuchi Akiko , Ohnuma Takehiro , Kawamura Tatsuyoshi , Umeda Yoshiyasu , Kawahara Yu , Nakamura Yasuhiro , Kiniwa Yukiko , Yamasaki Osamu , Fukushima Satoshi , Kawazu Masahito , Suzuki Yutaka , Nishikawa Hiroyoshi , Hanazawa Toyoyuki , Ando Mizuo , Inozume Takashi , Togashi Yosuke
Published: July 2024

Multiplexed fluorescent immunohistochemistry
Table S3 from Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer
Authors: Yang Sheng , Zhang Dongsheng , Sun Qingyang , Nie Hongxu , Zhang Yue , Wang Xiaowei , Huang Yuanjian , Sun Yueming
Published: July 2024

Supplementary Table S3: RT-qPCR Primers and short hairpin RNAs (shRNAs) sequence of BHLHE40
Figure S9 from Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer
Authors: Yang Sheng , Zhang Dongsheng , Sun Qingyang , Nie Hongxu , Zhang Yue , Wang Xiaowei , Huang Yuanjian , Sun Yueming
Published: July 2024

Figure S9. BHLHE40 promoted the invasion and migration of colorectal cancer induced by the TGFβ pathway in vitro. (A, B) Transwell assays and wound healing assays were used to assess the migration and invasion abilities of LoVo cells and HCT116 cells with or without treatment of TGFβ or LY2109761. Scale bar: 100 µm. All data were presented as the means ± SD of three independent experiments. *, P < 0.05, **, P < 0.01, and ***, P < 0.001, Student t test.
Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote Progression in Acute Myeloid Leukemia
Authors: Huang Deyu , Yu Zebin , Lu Huan , Jiang Penglei , Qian Xinyue , Han Yingli , Qian Pengxu
Published: July 2024

Acute myeloid leukemia (AML) is an aggressive and heterogeneous hematologic malignancy. In elderly patients, AML incidence is high and has a poor prognosis due to a lack of effective therapies. G protein–coupled receptors (GPCR) play integral roles in physiologic processes and human diseases. Particularly, one third of adhesion GPCRs, the second largest group of GPCRs, are highly expressed in hematopoietic stem and progenitor cells or lineage cells. Here, we investigate the role of adhesion GPCRs in AML and whether they could be harnessed as antileukemia targets. Systematic screening of the impact of adhesion GPCRs on AML functionality by bioinformatic and functional analyses revealed high expression of ADGRE2 in AML, particularly in leukemic stem cells, which is associated with poor patient outcomes. Silencing ADGRE2 not only exerts antileukemic effects in AML cell lines and cells derived from patients with AML in vitro, but also delays AML progression in xenograft models in vivo. Mechanistically, ADGRE2 activates phospholipase Cβ/protein kinase C/MEK/ERK signaling to enhance the expression of AP1 and transcriptionally drive the expression of DUSP1, a protein phosphatase. DUSP1 dephosphorylates Ser16 in the J-domain of the co-chaperone DNAJB1, which facilitates the DNAJB1–HSP70 interaction and maintenance of proteostasis in AML. Finally, combined inhibition of MEK, AP1, and DUSP1 exhibits robust therapeutic efficacy in AML xenograft mouse models. Collectively, this study deciphers the roles and mechanisms of ADGRE2 in AML and provides a promising therapeutic strategy for treating AML.

Significance: Increased expression of the adhesion GPCR member ADGRE2 in AML supports leukemia stem cell self-renewal and leukemogenesis by modulating proteostasis via an MEK/AP1/DUSP1 axis, which can be targeted to suppress AML progression.
Supplementary Figure S2 from The Novel ATR Inhibitor M1774 Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs
Authors: Jo Ukhyun , Arakawa Yasuhiro , Zimmermann Astrid , Taniyama Daiki , Mizunuma Makito , Jenkins Lisa M. , Maity Tapan , Kumar Suresh , Zenke Frank T. , Takebe Naoko , Pommier Yves
Published: July 2024

This figure shows a Volcano plot of abundance ratio between M1774 and control.
Supplementary Data set 1 from The Novel ATR Inhibitor M1774 Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs
Authors: Jo Ukhyun , Arakawa Yasuhiro , Zimmermann Astrid , Taniyama Daiki , Mizunuma Makito , Jenkins Lisa M. , Maity Tapan , Kumar Suresh , Zenke Frank T. , Takebe Naoko , Pommier Yves
Published: July 2024

Data set of Tandem mass tag (TMT)-Liquid Chromatography Mass Spectrometry (LC-MS)
Figure S1 from Hepatitis B Virus–Mediated m6A Demethylation Increases Hepatocellular Carcinoma Stemness and Immune Escape
Authors: Meng Yuting , Shu Zheyue , Wang Xueyao , Hong Liang , Wang Baohua , Jiang Jingjing , He Kangxin , Cao Qingyi , Shi Fan , Wang Hai , Gong Lan , Diao Hongyan
Published: July 2024

Supplementary Figure S1 shows the extended data of "Enhanced malignancy and declined m6A levels in HBV-related HCC"
Supplementary Table S5 from Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth
Authors: Muthukrishnan Sree Deepthi , Qi Haocheng , Wang David , Elahi Lubayna , Pham Amy , Alvarado Alvaro G. , Li Tie , Gao Fuying , Kawaguchi Riki , Lai Albert , Kornblum Harley I.
Published: July 2024

Patient samples utilized for RNA-sequencing
Supplementary Data: Video 2 from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3
Authors: Ebegboni Vernon Justice , Jones Tamara L. , Brownmiller Tayvia , Zhao Patrick X. , Pehrsson Erica C. , Sundara Rajan Soumya , Caplen Natasha J.
Published: July 2024

SK-N-MC-CRISPR-ETS1a
Supplementary Figure 1 from Germline Testing Identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors
Authors: Mohindroo Chirayu , Baydogan Seyda , Agarwal Parul , Wright Robin D. , Prakash Laura R. , Mork Maureen E. , Klein Alison P. , Laheru Daniel A. , Maxwell Jessica E. , Katz Matthew H.G. , Dasari Arvind , Kim Michael P. , He Jin , McAllister Florencia , De Jesus-Acosta Ana
Published: July 2024

Supplementary Figure 1: Flow diagram showing the type of testing in both the cohorts.
Supplementary Figure 2 from Nfe2l2/NRF2 Deletion Attenuates Tumorigenesis and Increases Bacterial Diversity in a Mouse Model of Lynch Syndrome
Authors: Haller Felix , Jimenez Kristine , Baumgartner Maximilian , Lang Michaela , Klotz Anton , Jambrich Manuela , Busslinger Georg , Müllauer Leonhard , Khare Vineeta , Gasche Christoph
Published: July 2024

Supplementary Figure 2: Loss of Nrf2 does not induce apoptosis.
Supplementary Table S3 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Table S3
Supplementary Figure S18 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Fig. S18. Combination with SOC.
Supplementary Figure 21 from SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
Authors: Hou Yueru , Cao Yejin , He Ying , Dong Lin , Zhao Longhao , Dong Yingjie , Niu Ruiying , Bi Yujing , Liu Guangwei
Published: July 2024

Fig.S21. SIRT3 deficiency enhances NAD+-glycolysis activities for promoting TFH cell differentiation in anti-tumor immunity.
Supplementary Figure 18 from SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
Authors: Hou Yueru , Cao Yejin , He Ying , Dong Lin , Zhao Longhao , Dong Yingjie , Niu Ruiying , Bi Yujing , Liu Guangwei
Published: July 2024

Fig. S18. SIRT3 deficiency promotes TFH differentiation through mTOR-HIF1α coupled with NAD+-dependent glucose metabolism pathway.