bluuebunny/crossref_metadata_2025 huggingface dataset:
Additional benefits of combined ceftriaxone and adipose-derived mesenchymal stem cells on revamping the outcomes in rodent after acute spinal infection
Authors: Yin Tsung-Cheng , Lin Hung-Sheng , Sung Pei-Hsun , Chiang John Y. , Yang Chien-Hui , Yip Hon-Kan , Chen Kuan-Hung
Published: October 2024

This study tested whether combined ceftriaxone and adipose-derived mesenchymal stem cells (ADMSCs) would defend the spinal cord against acute spinal infection (ASI) in rodent. Adult-Male-SD rats were grouped into groups 1 (SC)/2 (ASI)/3 (ASI + ceftriaxone from days 2 to 28 after ASI induction)/4 (ASI + allogenic ADMSCs from day 2 for a total of 3 doses/3 consecutive intervals by intravenous injection)/5 (ASS + combined ceftriaxone and ADMSC) and spinal cord tissues were harvested by day 28. Circulatory levels of TNF-α/IL-6 at days 7 and 28, and these two parameters in spinal fluid at day 28 were lowest in group 1, highest in group 2, significantly lower in group 5 than in groups 3/4, and significantly lower in group 3 than in group 4 (all p < 0.0001). The day-28 bacterial colony formation unit (CFU) in vertebral bone and circulatory WBC counts at the time points of days 7/14/28, and the protein expressions of upstream (TRL-2/TLR-4/MYD88/TRAF6/IKKα/IKKβ /IKBβ/p-NF-κB) and downstream (IL-1β/IL-6/TNF-α/IFN-γ/iNOS) inflammatory signalings displayed a similar pattern of inflammatory biomarkers in spinal fluid among the groups (all p < 0.0001). By day 28, the bone injury score/bone marrow density/ratio of bone volume (BV) to the bone tissue volume (TV)/ratio of bone surface (BS) to BV/ratio of BS to bone TV/trabecular number exhibited an opposite, whereas the trabecular space exhibited an alike pattern of inflammatory biomarkers among the groups (all p < 0.0001). Combined ceftriaxone and ADMSCs therapy offered an additional benefit on protecting the vertebral bone/spinal cord against ASI damage.
Review of Ultrasonic Methods for the Identification of Defects in Epoxy Matrix and Carbon Fiber Composites
Authors: Hernández Melany Isabel Pinilla , Contreras Gastón Sanglier , Fernández Eduardo José Lopez , Tur Sofia Melero , Gonzalez-Lezcano Roberto Alonso
Published: October 2024

Non-Destructive Testing (NDT) methods, and especially, ultrasounds have gone from being a mere laboratory curiosity to an indispensable tool in the industry as a primary means of determining the level of quality achieved in its products (ASM, 1989; Barbero, 1999). This study will identify and apply the main physical phenomena of interaction of an ultrasonic wave in a composite material, to see if through this type of waves, you can detect defects of the type of porosity or delaminations in these materials. The percentages of reflected and transmitted waves in real cases of defects in the composite material will also be studied. It will be shown if the frequencies and intensities of the waves are adequate to find this type of defects or imperfections in the material.The theoretical study of the ultrasonic wave seeks to help researchers in the development of equipment that uses the methodology of immersion ultrasound for the inspection of materials in the search for 'defects' and to understand the physics of the test.
Efficacy of various mulches for modulation of strawberry (Fragaria x ananassa Duch.) yield, quality and shelf life
Authors: Darshan Devi
Published: October 2024

High temperature and low moisture-holing capacity in soil are one of the major constraints for strawberry production under southeastern region, particularly in subtropical climate of Rajasthan. To mitigate these challenges, the current experiment was conducted to examine the impact of different mulching materials on strawberry (Fragaria x ananassaDuch.) cv. Camarosa on yield, quality and shelf life of strawberry fruits under southeastern region of Rajasthan. The application of black polyethylene mulch significantly improved the plant height, the number of leaves per plant, number of stolon’s per plant, berry weight, berry length, berry width, soluble solid content, TSS: acid ratio, juice content, vitamin C, reducing sugar, non-reducing sugar, total sugars, anthocyanin, as well as leaf nitrogen, leaf phosphorus, leaf potassium content. It also resulted low acidity compared to control. On the other hand the use of wheat straw reduced weight loss, and fruit spoilage, while enhancing the shelf life of fruits as compared to black polyethylene mulch. Hence, it can be concluded from the present investigation that the application of black polyethylene mulch significantly improved the vegetative growth, physio-chemical properties and leaf nutrients composition of strawberry plants followed by silver black polyethylene mulch. Meanwhile, organic mulches (wheat straw & paddy straw) significantly reduced the weight loss, minimized fruit spoilage and improved the shelf life of the fruits.
Anais da Jornada da Residência Médica em Cirurgia da Mão do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRP-USP) - 2024
Authors: Rezende Luis Guilherme Rosifini Alves
Published: October 2024

No dia 17 de outubro de 2024, sábado, realizou-se no Anfiteatro Prof. Marcondes, no 11º Andar do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRP-USP) a Jornada da Residência Médica em Cirurgia da Mão do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto (HCFMRP-USP) – Edição de 2024.  Este evento teve como objetivo promover e divulgar os conhecimentos das diferentes linhas de pesquisa da Residência Médica e do Grupo de Cirurgia da Mão, Microcirurgia e Membro Superior (do Complexo HC-FMRP-USP), representada pelos doze Médicos Residentes do Programa de Residência Médica em Cirurgia da Mão do HCFMRP-USP. As apresentações contemplaram os trabalhos que são considerados como pré-requisitos para a atividade acadêmica e como pré-requisito para o “Exame de Suficiência para obtenção do Título de Especialista em Cirurgia da Mão”, aplicado pela Sociedade Brasileira pertinente, conforme normativas e regulamentos internos. Os trabalhos foram avaliados previamente, apresentados e discutidos com o Coordenador e Responsável pelo Programa de Residência Médica em Cirurgia da Mão, e equipe de Preceptores, além de contar com a participação híbrida de convidados selecionados, membros da equipe e egressos do Programa de Residência Médica em Cirurgia da Mão do Complexo HC-FMRP-USP. Assim, os Médicos Residentes, de uma subespecialidade que permite atribuição de RQE pelo Conselho Federal de Medicina (CFM), passa a demonstrar a oportunidade de ensino e competências no formato de um centro formador tradicional, e a contribuição dos projetos e pesquisas que beneficiarão inúmeros pacientes, prestando assistência e auxílio, além de fortalecer e auxiliar protocolos internos utilizados por nossa instituição. O evento, também mostrou o conhecimento e preparo para a carreira, cujos Médicos Residentes passarão a se inserir no mercado de trabalho. Jornada da Residência Médica em Cirurgia da Mão do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto (HCFMRP-USP) – Edição de 2024, passará a ocorrer como evento anual, estimulando o Ensino e Pesquisa. Prof. Dr. Luis Guilherme Rosifini Alves Rezende Professor do Departamento de Ortopedia e Anestesiologia da FMRP-USP/ Responsável pela Divisão de Cirurgia da Mão, Microcirurgia e Cirurgia do Membro Superior HCFMRP-USP /Responsável pelo Programa de Residência Médica em Cirurgia da Mão do HCFMRP-USP
Enucleação de Cisto da Bifurcação Vestibular: Relato de Caso Clínico
Authors: Santos Jordan Sander Batista , Picanço Álvaro Rabelo , Costa João Victor Rodrigues , Campos Marcos Vinícius Carvalho
Published: October 2024

O cisto da bifurcação vestibular (CBV) é um cisto odontogênico inflamatório que se destaca por sua raridade, se desenvolve na bifurcação da face vestibular do primeiro molar inferior permanente, em crianças de 6 a 12 anos, representa cerca de 3% de todas as incidências císticas na mandíbula, sua patogênese é incerta. Apresenta características clínicas, muitas vezes semelhantes a outros cistos inflamatórios, apresenta-se como uma imagem radiolúcida, unifocal, circunscrita com bordas nítidas e definidas, o aumento do volume ósseo ao redor do cisto, reabsorção óssea na região de bifurcação das raízes e inclinação das mesmas em direção à parte interna da mandíbula. A compreensão das características radiográficas específicas, em conjunto com a análise clínica e histológica, permite diferenciar o CBV de outras patologias e determinar o tratamento adequado. O presente trabalho relata a remoção cirúrgica de cisto da bifurcação vestibular em uma paciente do gênero masculino, de 9 anos de idade. O procedimento cirúrgico foi realizado na clínica escola da UNAMA Santarém, através da técnica de enucleação.
BIOCHEMICAL ALTERATIONS AS TOTAL PROTEINS (TP) ASPARTATE AMINO TRANSFERASE (AAT) AND ALANINE AMINOTRANSFERASE (ALAT) INDUCED BY PERMETHRIN AND 25% EC IN THE FISH CYPRINUS CARPIO (L.)
Authors:   Post-Doctoral Fellow, Department of Zoology and Aquaculture Acharya Nagarjuna University, Nagarjunanagar-522 510, A.P., India., Balakrishna Naik K.
Published: October 2024

Permethrin, a synthetic pyrethroid, technical grade and 25% EC when exposed to both lethal and sublethal concentrations, in the fish Cyprinus carpio in vivo, in the laboratory induced alterations in the vital organs. When had an exposure of four days and 10 days respectively for both the toxicants.The tissues Gill, Liver, Kidney, Brain and Muscle are only tested. The biochemical alterations that are assayed includes total proteins (TP), Aminotransferases Aspartate and Alanine (AAT & ALAT). The fish, in the vital organs that are studied had appreciable quantity of percentage as decrement of TP and increment of AAT and ALAT enzymes. Proteolysis and inhibition of protein synthesis resulted by which decrement and gluconeogenesis as a consequence increment of the amino transferases. An hormonal imbalance that resulted due to toxic stress that might had an impact on the effect of the toxicants. They also served as indices of the pollutants as toxicants.
EFFECTIVENESS OF CONTINUOUS GLUCOSE MONITORING IN UNCONTROLLED TYPE-2 DIABETICS IN TERTIARY HEALTHCARE CENTRE
Authors:   MBBS, M.D (Medicine) ACHD (Physician) Northern Railway Central Hospital (NRCH), New Delhi., Kansal Madhu , Kumar Singh Bimal ,   MBBS (Hons) MD Medicine, Chief Physician Head of Department NRCH, New Delhi., Chaubey Abhishek ,   DNB Medicine Department of General Medicine NRCH, New Delhi.
Published: October 2024

Long term diabetic complications can be prevented or reduced by achieving good metabolic control, reflected by HbA1c <6.5Ã‚Â–7.0%.1-3 Glucose excursions might also contribute to the development of diabetic complications.4,5 Fear of hypoglycemia limits the ability to reach strict glycemic control, because it is usually accompanied by reluctance of the patient to intensify insulin therapy. Indeed, the goal of intensive therapy is to normalize HbA1c and control fasting and postprandial glycemia, while concurrently limiting the number and severity of hypoglycemic events. To reach tight glycemic control, frequent self- monitoring of blood glucose (SMBG) must be performed.6 SMBG devices provide the patient with accurate but discreet blood glucose levels. They do not provide trend information nor do they reflect glycemic fluctuations, which is possible by using continuous glucose monitoring (CGM) systems. Thus, implementation of strict glycemic control may be facilitated by a CGM device. This manuscript critically reviews the proposed benefits and indications of CGM and the current evidence of CGM on health outcomes in diabetic patients.
FLUID MANAGEMENT IN SPACE: OVERCOMING GRAVITATIONAL CHALLENGES FOR SAFE IV THERAPY ON MARS AND BEYOND
Authors: Tom Joseph Chrison , S. Appannavar Vinay
Published: October 2024

In space and on other planets, the challenges of fluid management for human health, particularly through intravenous (IV) therapy, become significant due to the altered effects of gravity on fluids. Understanding how microgravity and varying gravitational environments impact fluid dynamics in the body and IV administration is essential for medical care in extraterrestrial settings. This paper reviews the effects of gravity on fluids, particularly in space and Martian environments, explores the challenges of IV fluid therapy in zero gravity, and offers potential solutions for managing fluid therapy in these conditions. By combining research from terrestrial fluid management practices and data from space missions, we aim to offer insights into the safe administration of IV fluids in space and beyond.
OPTIMIZATION OF CONSERVATION CONDITIONS AFTER LIFE-STATE CAPTURE OF CALLINECTES AMNICOLA
Authors:   Laboratoire de Biotechnologie, Agriculture et Valorisation des Ressources Biologiques (LBAVRB), UFHB, UFR Biosciences, 22 BP 582 Abidjan 22., Verdier Abouo Nguessan ,   Laboratoire des Procedes Industriels de Synthese de lEnvironnement et des Energies Nouvelles (LAPISEN), INPHB, DFR GCAA, BP 1093 Yamoussoukro., Martial Thierry Akely Pierre ,   Ecole Normale Superieure, 08 BP 10 Abidjan 08., Kadjo Vincent ,   Universite Peleforo GON COULIBALY, Unite de Formation et de Recherches en Sciences Biologiques, Departement de Biologie Animale, BP 1328 Korhogo, Cote dIvoire., Compaore Dominique ,   Laboratoire de Biotechnologie, Agriculture et Valorisation des Ressources Biologiques (LBAVRB), UFHB, UFR Biosciences, 22 BP 582 Abidjan 22., Maruis Biego Godi ,   Laboratoire de Biotechnologie, Agriculture et Valorisation des Ressources Biologiques (LBAVRB), UFHB, UFR Biosciences, 22 BP 582 Abidjan 22., Emmanuel Assidjo Nogbou ,   Laboratoire des Procedes Industriels de Synthese de lEnvironnement et des Energies Nouvelles (LAPISEN), INPHB, DFR GCAA, BP 1093 Yamoussoukro.
Published: October 2024

The aim of this study was to determine the optimal conditions for the preservation of Callinectes amnicola from the Sud-Comoe region after capture in the live state, with a view to extending their lifespan outside their natural habitat, and making good-quality Callinectes amnicola available to help alleviate the shortage of animal protein in the Assinie mafia region, Cote dIvoire. To this end, a fractional factorial design was set up and enabled eight (08) experiments observed over ten (10) days to be carried out. The study variables are : X1 (Number of species), X2 (Volume of water), X3 (Number of leaves), X4 (Quantity of sand) and Y (Mortality rate). The analysis of the optimization results of the first-stage model was performed by the Excel solver based on the GRG algorithm. The results obtained indicate the values of X1 (82.58 or 83 species), X2 (0.479 L), X3(93.78 or 94 leaves) and X4 (3.798 Kg) of sea sand for a life span increasing from three (03) to nine (09) days.
Cómo se informa suicidio. Una guía para periodistas y comunicadores
Authors:   Universidad Católica Luis Amigó, Kratc Gil Eliza , Vega Seña Marcos Fidel ,   Universidad Católica Luis Amigó
Published: October 2024

Esta publicación hace parte de la investigación sobre la prevención del comportamiento suicida, Hacia una comprensión integral e integradora del suicidio. La realidad no vista por unos y padecida por otros. La prevención del suicidio es una posibilidad de todos y todas, liderada por la Universidad Católica Luis Amigó (sede Medellín, Colombia). Su contenido guía, de manera especial, a comunicadores, comunicadoras organizacionales, así como a periodistas, locutores y a todas aquellas personas que tengan responsabilidades comunicativas, como docentes, funcionarios públicos y privados, entre otros públicos. Su aplicación es práctica porque contiene orientaciones de cómo hablar y comunicar los casos de intentos suicidas o suicidios consumados en la vida cotidiana y de cómo los medios deben abordar los contenidos.
Türkiye Türkçesinde Cümlenin Yan Cümleye Dönüşme Süreci
Authors: Karaca Hasan
Published: October 2024

Söz dizimsel yapılar, yapı ve anlam bakımından hem içe hem dışa dönük ilişkiler ağına sahiptir. Bir söz dizimsel yapıda birden fazla yargı, tek bir yargı etrafında kullanıcının amacına göre şekillenebilir. Bu şekillenmelerden birisi de müstakil cümlenin yan cümleye dönüştürülüp temel cümleye bağlanmasıdır. Müstakil cümlenin yüklemi çekimli, yargısı tam ve bağımsızdır. Bunların bağımlı hâle getirilmesiyle cümle, yan cümleye dönüşür. Yan cümleye dönüşme süreci anlamsal ilişkilendirme veya birtakım yapısal değişikliklerle gerçekleşir. Yapı olarak yan cümleye dönüşme fiilimsi, alıntı, aktarma cümleleri; yargıyı bağımlı kılarak yan cümleye dönüşme sıralı, bağlı, ara cümleler ve açıklama cümleleri şeklinde ortaya çıkmaktadır. Fiilimsiler yüklem olarak yargıya isim, sıfat, zarf değeri kazandırır. Yan cümlenin hangi fiilimsi ile kurulacağı temel cümledeki göreviyle ilgilidir. Cümlede isimlerin üstleneceği görev özne, nesne, yüklem ise yüklem genellikle isim-fiil, bu görevleri sıfat işleviyle karşılayacaksa sıfat-fiil, zarf ise zarf-fiil veya şart-fiil olur. Bunlarla kurulan yan cümle çeşitli öge ilişkileri, isim işletimi, tamlama ve kelime grubu bünyesinde isim hükmünde temel cümleyi tamamlar. Ki’li birleşik cümleler ve bazı bağlaçlarla (belki, çünkü, gerçi, halbuki, madem / mademki, vakıa) kurulmuş bağlı cümlelerde de müstakil cümleler yan cümleye dönüşür. Kip ve zaman ile şahıs çekimine girmiş fiillerin veya ek-fiille çekimlenmiş isimlerin kurduğu müstakil cümleler yan cümle olarak kullanılabilir. Dolayısıyla sıralanmış cümleler, ara cümleler, parantez içindeki cümleler yapısal bir yan cümle ve temel cümle ilişkisine sahip olmasalar da yan cümle hükmünde yargı barındırabilirler. Cümlenin yan cümleye dönüştürülerek kullanılması dil ve anlatıma etkili, özlü, akıcı söyleyiş gücü katar.
Tereke Kayıtlarına Göre Müslüman Ailelerin Sosyal ve Ekonomik Yapısı Üzerine Bir İnceleme: Ayıntab Örneği (H. 1233-1309 / M. 1818-1891)
Authors: Sağlamer Fatma , Gülenç Ahmet
Published: October 2024

Osmanlı Devleti’nde toplumun en küçük birimini teşkil eden aile hakkındaki araştırmaların temel kaynakları tereke defterleridir. Tereke defterleri ailenin idari, sosyal, ekonomik, dinî ve kültürel yapısı hakkında önemli bilgiler ihtiva etmektedir. Defterlerde şahısların yerleşim birimleri, nüfus bilgileri, eş ve çocuk sayıları, alacak-verecek ve servet miktarları, hayatta iken kullandıkları menkul-gayrimenkul her türlü mal ve eşyaları kayıt edilmiştir. Bu geniş envanter kayıtları, ailenin sosyoekonomik yapısının ortaya çıkarılmasında araştırmacılara büyük kolaylık sağlamaktadır. Çalışmanın temel problematiği, günümüzde bile tartışmalara konu olan Osmanlı’da çok eşlilik, çocuk sayıları, eş sayıları ve servetin toplumsal gruplar arasındaki dağılımını ortaya çıkarmaktır. Ayrıca servet miktarlarının eş sayıları, çocuk sayıları, mehir miktarları ve toplumsal statülerle olan ilişkisini ortaya çıkarmak çalışmanın diğer bir problematiğidir. Bu amaçla Ayıntab’ta ikamet etmekte iken vefat eden 235 Müslüman erkek şahsın tereke kayıtları incelenmiştir. İncelenen tereke kayıtları, Ayıntab’a ait 16 adet şer’iyye sicilinden elde edilmiş olup 1818-1891 yılları arasını kapsamaktadır. İncelenen dönemde, Ayıntab’taki Müslüman halkın çoğunlukla tarihi mahallelerde ikamet ettikleri, ortalama hane sayılarının Osmanlı Devleti’nin genel kabul gören hane sayısına yakın olduğu, genellikle tek eşle evliliği tercih ettikleri ve servet miktarları arttıkça eşlerine verdikleri mehir miktarları, sahip oldukları eş sayıları ve çocuk sayılarının da arttığı tespit edilmiştir. Çalışma, genelde Osmanlı ailesi özelde ise Ayıntab ailesinin sosyal ve ekonomik yapısı ile ilgili araştırmalara katkı sağlayacaktır.
Türkiye’de Gelir Dağılımının Sosyoekonomik Belirleyicileri Üzerine Bir Çalışma
Authors: Kayapalı Aslan Bengü , Arslan İbrahim
Published: October 2024

Gelir dağılımı, bir ülkenin gelişmişlik düzeyinin belirlenmesinde başvurulan makroekonomik bir gösterge olduğu gibi toplumda huzur, refah ve eşitliğin tesis edilmesinde sahip olduğu etkiye bağlı olarak sosyal bir boyuta da sahiptir. Gelir dağılımı kavramının sahip olduğu sosyoekonomik karakteristik, konunun iktisat biliminin yanında sosyal bilimlerce de araştırılan bir yönü olduğunun göstermektedir. Gelir dağılımında eşitliğin sağlanması, öncelikle bireylerin daha sonra bölgelerin, sektörlerin, vb. aralarındaki eşitsizliklerin ortadan kalkmasında etkili olmaktadır. Buradan hareketle bireyler başta olmak üzere bir ülkedeki ekonomi içerisindeki unsurlar arasındaki eşitsizliklere neden olan faktörlerin belirlenerek, eşitsizlikleri azaltıcı ve önleyici politikaların geliştirilmesi gerekmektedir. Bu bağlamda Türkiye’de 1987-2017 yılları arasında gelir dağılımını belirleyen sosyoekonomik faktörlerin belirlenmesi ve gelir dağılımı eşitsizliğini önleyici politika önerilerinin sunulması bu çalışmanın amacını oluşturmaktadır. Ekonomik gelişmenin sağlanmasında önemli bir paya sahip olan gelir dağılımında eşitliğin sağlanması, beraberinde sosyal adalet ve eşitlik normlarına bağlı olarak toplumda huzur ve refahın sağlanmasını getireceği için gelir dağılımı konusu ekonomik göstergelerin yanında yönetim ve topluma ilişkin göstergelerle birlikte değerlendirilmelidir. Bu sebeple çalışmada kurumsal kalite endeksine yer verilmektedir. Çalışmada ARDL yöntemi kullanılarak ekonometrik hesaplamalar yapılmıştır. Gelir dağılımındaki eşitsizliğin azaltılmasında etkili olacağı düşünülen ve ekonometrik modelde kontrol değişken olarak yer alan kurumsal kalite endeksinin diğer bağımsız değişkenler arasındaki bütünleşik etkisi de araştırılmaya çalışılmıştır. Çalışmada ortaya çıkan bulgular, öncelikle kurumsal kalite endeksinin Türkiye’de gelir dağılımı eşitsizliğinin çözümünde önemli bir etkiye sahip olduğunu göstermiştir. Çalışmanın sonuç bölümünde, Türkiye’de gelir dağılımı eşitsizliğinin azaltılması ve önlenmesine yönelik politikaların geliştirilmesine yönelik çözüm önerileri sunulmaktadır.
Advanced machine learning for predicting groundwater decline and drought in the Rabat–Salé–Kénitra region, Morocco
Authors: Elmotawakkil Abdessamad , Enneya Nourddine
Published: October 2024

The Rabat–Salé–Kénitra region of Morocco faces critical groundwater challenges due to increasing demands from population growth, agricultural expansion, and the impacts of prolonged droughts and climate change. This study employs advanced machine learning models, including artificial neural networks (ANN), gradient boosting (GB), support vector regression (SVR), decision tree (DT), and random forest (RF), to predict groundwater storage variations. The dataset encompasses hydrological, meteorological, and geological factors. Among the models evaluated, RF demonstrated superior performance, achieving a mean squared error (MSE) of 484.800, a root mean squared error (RMSE) of 22.018, a mean absolute error (MAE) of 14.986, and a coefficient of determination (R2) of 0.981. Sensitivity analysis revealed significant insights into how different models respond to variations in key environmental factors such as evapotranspiration and precipitation. Prophet was also integrated for its ability to handle seasonality in time-series data, further enhancing prediction reliability. The findings emphasize the urgent need to integrate advanced predictive models into groundwater management to address groundwater depletion and ensure sustainable water resources amid rising drought conditions. Policymakers can use these models to regulate extraction, promote water-saving technologies, and enhance recharge efforts, ensuring the sustainability of vital groundwater resources for future generations.
Measurement and thermal characterization of graywater discharge events for house-central collection systems in the context of heat recovery
Authors: Mehling Simon , Hörnlein Stefanie , Schnabel Tobias , Beier Silvio , Londong Jörg
Published: October 2024

Within this work, a detailed measurement with a temporal resolution of 3 s of flow rate and temperature of a house-central graywater system was carried out. Individual discharge events could be identified and assigned to specific types of use via user surveys and current measurements. Due to the consistent recording of measurement errors, the accuracy of the determined data could be improved. Error rates of approximately 0–30% were determined, depending on the tab. Thus, accurate statements on the existing temperature distribution for the graywater of specific tabs could be determined. Tab-specific temperature distributions were calculated with ranges of 16–50 °C and an overall mean value of approximately 28 °C. Furthermore, a novel data basis could be provided by evaluating the time-related rate of change of temperatures. This enables more precise simulations to be carried out. For some tabs, significant differences to previous assumptions became apparent. The high temporal resolution of the data also enables simulative considerations that go beyond previous longer-scale energy balances.
Wastewater desalination for irrigation in inland regions
Authors: Sanciolo Peter , Haby Carl , Sharma Ashok K. , Muthukumaran Shobha , Gray Stephen
Published: October 2024

Desalination using membrane processes is increasingly being implemented in coastal regions of the world to meet the water needs of the growing population. The use of this water treatment option to meet the growing water needs in inland regions, however, is impeded by the cost and regulatory challenges associated with responsible disposal of the concentrate brine. For inland regions of Australia, the use of evaporation ponds (EPs) is the only available brine management option. The high cost associated with construction and the high land requirements for EPs necessitates low waste brine volume production. This desktop study investigated the feasibility of achieving very high water recoveries and very low waste brine volumes in the reverse osmosis desalination of municipal wastewater for irrigation of crops near the inland town of Horsham, Victoria, Australia. Interstage lime and soda ash softening was selected as the means of removal of the scalants that prevent the achievement of high water recovery. It is hoped that this study will provide valuable information to aid in the planning of water reclamation operations for agricultural applications in inland areas at a time of increasing demand for water for food production and forecasts of population growth and climate change.
AFROCENTRICIDADE
Authors: Fraga Celestino Livia
Published: October 2024

Este artigo possui como base a afrocentricidade buscando analisar as percepções de espaço e tempo sagrado nas comunidades dos terreiros de candomblé. Em um processo de forte dominação colonial em que vivemos, a afrocentricidade é uma abordagem necessária por colocar o pensamento africano, do continente e da diáspora, no centro do discurso e não mais como margem. Assim, as pesquisas que tratam           das cosmopercepções afrodiaspóricas abrem possibilidades de perceber o mundo com outros olhares, outros sentidos de espaço e tempo. Com referências pautadas na afrocentricidade e, em minha vivência enquanto pessoa de axé, este artigo trata de maneira introdutória algumas discussões sobre espaço e tempo para as  comunidades de terreiro. No candomblé as noções de espaço e tempo sagrados são vividas a partir das cosmopercepções afrodiaspóricas percebendo o mundo e a relação com as pessoas a partir de outras percepções e sentidos atraleadas a ancestralidade, natureza, comunidade e axé.
SABERES QUILOMBOLAS E INTERCULTURALIDADE
Authors: Da Silva Lima Taciani Do Socorro , Nascimento dos Anjos Danilo , Dos Santos Fernandes José Guilherme
Published: October 2024

Esta pesquisa tem como objetivos compreender o lugar que ocupa os saberes das populações quilombolas, a fim de focá-los sob uma perspectiva intercultural, inclusive no campo educativo e, consequentemente, situar como esses conhecimentos foram ignorados, de acordo a proposta decolonial. O referencial teórico-metodológico está pautado, sobretudo, em Dussel (1977) e Quijano (2007), numa análise discursiva do pensamento decolonial, bem como de Fernandes (2016) numa abordagem intercultural dos saberes desses grupos tradicionais, com base em um levantamento bibliográfico que busca justificar as informações e as teorias defendidas (HERNÁNDEZ SAMPIERE et al., 2013). A análise dos resultados evidencia que, embora esses povos tenham resistido contra a cultura colonial para não perder seus saberes, ainda precisamos avançar em práticas educativas interculturais, sendo a desobediência epistêmica (MIGNOLO, 2005) fundamental neste processo.
Development of russian-mongolian foreign trade relations in food industry
Authors: Ishukov A. A. , Mikhaylenko V. I. , Solod A. V. , Frolova E. D.
Published: October 2024

In the context of shifting trade emphasis to the East, Russia attaches great importance to the development of cooperation with the Asia-Pacific countries, where Mongolia is a key partner. The purpose of the article is to reveal global trade trends and identify key areas for the development of Russian-Mongolian foreign trade relations in the food industry. Having conducted a comprehensive analysis of the economic and political factors shaping bilateral trade, the article provides insights into the challenges and opportunities for expanding cooperation in the food sector. Global trend in the food market is that China a leader. China accounts for the largest share (35%) in Russia turnover also. Mongolian trade ties with Russia are becoming closer year by year. This was demonstrated by the official visit of Russian President Vladimir Putin to Mongolia in September 2024. We can observe that Mongolia closely cooperates with such a region of Russia as Buryatia. Through a detailed examination of trade patterns, regulatory frameworks, and market trends, the study uncovers areas of untapped potential and identifies barriers to optimal trade flow. Drawing on industry best practices and case studies from other global food trade partnerships, the paper offers a series of practical recommendations for stakeholders. These recommendations cover infrastructure development, promotion of cultural exchange, harmonization of legal and regulatory frameworks, absorption and use of technology to create a more robust and sustainable trade ecosystem.
Characterization of Luciferase from Photorhabdus kayaii and its Application for In vivo Imaging Studies in Mice
Authors: Tarahomjoo Shirin , Ebrahimi Laleh , Valishahavaz Fatemeh , Taghdiri Maryam , Banihashemi Reza
Published: October 2024

Background:

Bioluminescence, or the production of light by luciferases, is the basis of
a well-known reporter technology. A quick way to study the efficacy of antimicrobial drugs and
vaccines is in vivo bioluminescence imaging (BLI). Photorhabdus spp. represent the only terrestrial
group of bioluminescent bacteria. The luciferase obtained from Photorhabdus luminescence
has been widely used in BLI studies. However, little information is available about the functions
of luciferases obtained from other members of this genera.

Objective:

This study aimed to evaluate the applicability of the luciferase obtained from Photorhabdus
kayaii for BLI studies.

Methods:

P. kayaii starE, an Iranian isolate of P. kayaii, was cultivated on NBTA agar plates. The
resulting colonies were cultured on McConkey agar to determine the bacterial phase. Bioluminescence
emission was measured using a multimode reader. The luciferase genes of this bacterium
were sequenced following the PCR amplification, and the corresponding amino acid sequences
were determined. The luciferase tertiary structure was then obtained from the TACOS web server
and compared to that of P. luminescence in CE software. The lux operon encoding the luciferase
(luxA and luxB genes) and substrate synthesis complex was cloned and expressed in Escherichia
coli BL21 (DE3) using the pBBR1MCS2_START vector. The luminescence emission during the
growth was examined. Moreover, the effects of pH and sodium deoxycholate (bile salt) on bioluminescence
emission were investigated. Appropriate conditions for the use of bioluminescent E.
coli for BLI studies in mice were demonstrated in terms of cell numbers and injection routes.

Results:

The bacterium was luminescent and in phase I. Its luciferase monomers (α and β) shared
100% amino acid homology with P. kayaii M-HU2 and more than 92% with P. luminescence. Tertiary
structures of the luciferase monomers were 93%- 95% identical to those of P. luminescence.
The lux operon was expressed in E. coli, and the maximum bioluminescence signal was observed
during the decelerating phase of growth. The bioluminescence at different pH values correlated
with the cell survival. The luminescence was emitted by cells exposed to the bile salt. A strong bioluminescent
signal was emitted from mice after subcutaneous injection of bioluminescent E. coli
at 107 CFU. However, no signals were emitted from mice that were administered the same cell
number via intraperitoneal injection. A 2.5-fold increase in the cell number resulted in bioluminescence
detection in the abdomen of mice after intraperitoneal injection and a 3.22-fold increase in
signal intensity after subcutaneous injection.

Conclusion:

These results demonstrated the usefulness of P. kayaii luciferase for BLI studies.
Multiple Machine Learning Models, Molecular Subtyping and Singlecell Analysis Identify PANoptosis-related Core Genes and their Association with Subtypes in Crohn’s Disease
Authors: Chen Yi , Zhang Lu , Huang Wan-Ying , He Rong-Quan , Huang Zhi-Guang , Li Hui , Song Rui , Zhang Jia-Wei , He Juan , Chen Gang
Published: October 2024

Background:

PANoptosis plays an important role in many inflammatory diseases.
However, there are no reports on the association between PANoptosis and CD.

Materials and Methods:

This study used five machine learning algorithms - least absolute
shrinkage and selection operator, support vector machine, random forest, decision
tree and Gaussian mixture models - to construct CD’s PANoptosis signature. Unsupervised
hierarchical clustering analysis was used to identify PANoptosis-associated subgroups
of CD. Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes
and Genomes (KEGG) pathway analysis, Gene Set Enrichment Analysis (GSEA) and
Gene Set Variation Analysis (GSVA) were conducted to compare the PANoptosis-associated
subgroups of CD among the potential biological mechanisms. Single sample
GSEA was used to assess immune microenvironmental differences among the subgroups.
The potential role of PANoptosis in CD was further explored using single-cell
RNA-Seq (scRNA-Seq) for PANoptosis scoring, differential analysis, pseudotime analysis,
cellular communication analysis and weighted gene co-expression network analysis
(WGCNA) analysis.

Results:

CD’s PANoptosis signature consisted of seven genes: CEACAM6, CHP2,
PIK3R1, CASP10, PSMB1, PSMB8 and UBC. The PANoptosis signature in multiple cohorts
had a strong ability to recognise CD. The levels of immune cell infiltration and the
vigour of the immune responses significantly varied between the two subpopulations of
CD associated with PANoptosis. Multiple lines of evidence from the GO, KEGG,
GSEA, GSVA, scRNA-Seq and WGCNA analyses suggested that I-kappaB kinase/NF-
kappaB signalling, mitogen-activated protein kinase (MAPK), leukocyte activation
and leukocyte migration were mechanisms closely associated with PANoptosis in CD.

Conclusion:

This study is the first to construct a PANoptosis signature with excellent efficacy
in recognising CD. PANoptosis may mediate the process of CD through inflammatory
and immune mechanisms, such as NF- kappaB, MAPK and leukocyte migration.
A Comprehensive Approach for Diabetic Foot Ulcer Management
Authors: Bakshi Anusha , Prajapati Bijal , Dharamsi Abhay , Sompura Krishna
Published: October 2024

Objectives:

This study aims to evaluate the efficacy of a comprehensive management
plan in the treatment of diabetic foot ulcers (DFUs). Evaluating the effects of wound debridement
on the outcomes of diabetic foot ulcers, advanced dressings, blood sugar control, and offloading
strategies are the main objectives. The study also intends to investigate the function of surgery in
managing chronic ulcers and preventing recurrences. The goal is to offer advice for managing
DFUs optimally and lowering related morbidity based on evidence.

Method:

The intervention program includes techniques like wound debridement, advanced dressings,
unloading modalities, blood sugar level control, and, where necessary, surgical treatments.
Growth factors, electrical stimulation, negative pressure wound therapy, bio-engineered skin, and
hyperbaric oxygen therapy are among the many treatments that are included. Regression models
are among the statistical analyses used to assess the efficacy of the overall management strategy.

Results:

Significant findings are presented in the results section, which shows how the holistic management
strategy improves DFU outcomes. Improved wound healing rates, reduced infection incidents,
and enhanced patient-reported outcomes are highlighted. The results underscore the significance
of maintaining blood sugar levels, wound debridement, and incorporating various therapeutic
modalities in DFU management.

Conclusion:

This study concludes by recommending a thorough and interdisciplinary approach to
DFU management. Maintaining blood sugar levels, debridement of the wound, sophisticated dressings,
unloading techniques, and surgical procedures are among the effective strategies that help reduce
morbidity and prevent serious complications related to diabetic foot ulcers. Additional investigation
is necessary to enhance and broaden these results for ongoing progress in the management
of diabetic foot ulcers.
A Retrospective Observational Study of Adverse Drug Reactions (ADR) Reported to ADR Monitoring Centre from 2010 to 2020
Authors: Srinivasan Akila , Selvarajan Sandhiya , Shivabasappa Santhosh , Singaravelu Arunmozhy
Published: October 2024

Background:

Adverse Drug Reactions (ADR) are one of the essential causes of hospital
admissions and pose a significant clinical and economic burden on the healthcare system.
The Adverse Drug Reaction Monitoring Centre (AMC) in JIPMER functioning under the Pharmacovigilance
Programme of India (PvPI) plays a vital role in ensuring medication safety by
routinely detecting and monitoring ADRs. Hence, this study aimed to assess the characteristics
of ADR reported from 2010 to 2020 in AMC JIPMER and to detect signals, if any. Objectives:
To study the characteristics of Adverse Drug Reactions (ADR) reported to a regional ADR monitoring
center from 2010 to 2020 and to detect signals of disproportionate reporting (SDRs) if
any from the reported ADRs.

Materials and Methods:

A total of 6007 ADR reports with a single suspect drug were included
for analysis from 2010 to 2020. The characteristics of these reports, including patient’s age and
gender, Number and percentage of ADRs, the causality of ADR using WHO UMC (World
Health Organization-Uppsala Monitoring Scale), the seriousness of the ADR, and outcome were
collected from the ADR reports. MedDRA (Medical Dictionary for Regulatory Activities) Preferred
Terms (PT) were used to classify adverse drug reactions. Causality analysis using the Naranjo
Algorithm and Preventability using Modified Schumock and Thornton criteria were performed
for the ADRs. The number and percentage of severe ADRs were analyzed. The System
Organ class of all the ADRs was enumerated. ADRs not mentioned in the US FDA (United
States Food and Drug Administration) product label (unlabelled reactions) were documented.
Unlabeled reactions with ≥3 ADR reports were included for signal detection by disproportionality
analysis.

Results:

Antineoplastic drugs, followed by antimicrobials, anticonvulsants, Anti snake venom,
and NSAID were the most common drugs implicated in ADRs. Skin and subcutaneous tissue
disorders were the most common System Organ Class (SOC) involved in the ADRs. Among the
6007 reports, 19.2% were serious ADRs. Most of the ADR reports were of possible causality
followed by probable and certain as per WHO UMC and Naranjo causality scales. Only ten
ADRs were preventable and one reaction (Tamoxifen-induced neuropathy) was eligible for signal
detection. Disproportionality analysis using a 2x2 contingency table showed insignificant
signal detection using the Reporting Odds Ratio (ROR) and Proportional Reporting Ratio
(PRR).

Conclusion:

Analysis of ADRs from an ADR Monitoring center functioning in a tertiary care
hospital shows antineoplastic drugs to be the most common drugs associated with adverse drug
reactions, with rash being the most common adverse effect. The majority of the ADRs were not
preventable. No Signals of Disproportionate Reporting (SDR) were detected in our study.
Promotion of Epithelial Healing in Oral Mucositis by hESC-Derived Mesenchymal Stem Cells via the PI3K/AKT Pathway
Authors: Lv Kejia , Gao Bicong , Ye Weijia , Shen Chenlu , Chen Tianchi , Wang Chaowei , Yao Hua
Published: October 2024

Introduction:

Oral mucositis (OM) is a common and debilitating side effect of cancer
therapies such as radiotherapy, chemotherapy, hematopoietic cell transplant, or their combinations.

Method:

This study focused on the reparative effects of human embryonic stem cell-derived mesenchymal
stem cells (hESC-MSCs) in OM and possible mechanisms. An ulcer model was created
in the rat buccal mucosa to mimic an in vivo animal model of OM mucosal injury, and hESC-MSCs
were injected 48h later to assess their reparative effects. In vitro, the efficacy of hESC-MSCs
in regulating apoptosis and proliferation in LPS- or 5-fluorouracil (5-FU)-injured HaCaT cells
was studied using a transwell coculture system. Subsequently, the PI3K inhibitor LY24002 was
used to assess whether hESC-MSCs regulated injured HaCaT cells through the PI3K/AKT pathway.
In vivo, we found that hESC-MSCs injection promoted OM healing in rats through the acceleration
of re-epithelialization and a decrease in apoptosis.

Results:

In vitro, our findings revealed that the hESC-MSCs treatment led to a reduction in the
quantity of HaCaT cells undergoing apoptosis. Western blot analysis revealed that hESC-MSCs
activated AKT, resulting in increased protein levels of PCNA and BCL-2 and decreased protein
levels of Bax and Caspase-3 whereas LY294002 reversed these changes.

Conclusion:

These findings suggest that hESC-MSCs promoted OM wound healing by stimulating
the proliferation of epithelial cells and inhibiting their apoptosis in rat models. Furthermore,
hESC-MSCs might mediate the PI3K/AKT pathway to modulate apoptosis/proliferation injured
by LPS or 5-FU in HaCaT cells.
Thiazolidine-4-one Analogues: Synthesis, In-Silico Molecular Modeling, and In-vivo Estimation for Anticonvulsant Potential
Authors: Mittal Payal , Ghanghas Deepak , Sharma Diksha , Shah Kamal , Arya Girish Chandra , Chaudhary Aarti , Dewangan Hitesh Kumar
Published: October 2024

Background:

Epilepsy is a critically deep-rooted CNS disorder affecting above 50 million
people all over the world. Thus, a safe and effective treatment that proves its worth in this ailment
is urgently needed. Thiazolidine-4-ones possess the molecules to be used as anticonvulsants.
The thiazolidinedione is a cyclic analogue of thiosemicarbazides and thioureas as well as a (bio)isostere
of hydantoin (imidazolidine-2,4-dione), which are recognized as novel anticonvulsant designs.

Aim:

This study aimed to develop and evaluate a novel thiazolidine-4-one derivative by three-component
condensation in one pot reaction method.

Methods:

A novel thiazolidine-4-one derivative was formulated by three-component condensation.
The selected OH (Alcohol) derivatives were found to be more potent; hence, a molecular
docking study against a selected target LGI1 LRR domain was performed. Various analytical tests
like FTIR and H1 NMR were accomplished. The FTIR was used to validate the existence of multiple
functional moieties like C-S, O-H, C=O, C-N, N=O, C-NH, C-O in the wave region from 3075
cm-1 – 1236 cm-1 and H1 NMR was employed to ascertain if the synthesized analogues had the
complete set of protons. Then, the anti-seizure activity of the selected compound was examined using
PTZ models in mice at three successive doses, i.e., 25, 50, and 100mg/kg, and compared with
standard ethosuximide.

Results:

The docking simulations were initiated using PyMOL after the binding site was determined
and the receptor and ligand were suitably prepared. It showed higher binding frequency in
comparison to the standard marketed drug Ethosuximide. FTIR and H1 NMR spectroscopy were
used to characterize the chemical components. Numerous functional groups, including O-H (alcohol),
C=O (ketones), N=O, C-NH, C-N, C-S, and C-O bending stretching, were visible in the synthesized
molecule accordingly. The synthesized compound was effective in inhibiting the convulsions
at the concentration of 100 mg/kg.

Conclusion:

The novel thiazolidine-4-one derivative showed promising activity and could be considered
for further investigation and dosage form preparation.
Antimicrobial Resistance of Environmental V. cholerae Non-O1/O139 Isolates: Systematic Review and Meta-analysis
Authors: Altafi Mana , Beig Masoumeh , Sami Fatima Moayad , Maleki Abbas , Kaviar Vahab Hassan , Shahryari Ali , Khadivar Parand , Sholeh Mohammad
Published: October 2024

Background:

The understanding of the antibiotic resistance status of environmental nonO1/nonO139 V. cholerae [NOVC] in relation to other illnesses, which can vary in severity from mild to life-threatening, is limited. However, it is important to note that NOVC-related infections are increasing and serve as a significant illustration of emerging human diseases associated with climate change. The primary objective of the present study was to assess the rates of resistance observed in environmental NOVC isolates across various years, and regions, and their resistance rates.

Methods:

We performed a systematic search of Scopus, PubMed, Web of Science, and EMBASE databases [until May 2024] following PRISMA guidelines. All statistical analyses were carried out using the statistical package R.

Results:

Our analysis included a total of 34 studies. According to the meta-regression, chlo-ramphenicol, rifampicin, ciprofloxacin, nalidixic acid, cotrimoxazole, kanamycin, trime-thoprim, amoxicillin/clavulanic acid, and tetracycline resistance rate increased over time. The lowest resistance rates were observed in Austria [amoxicillin; 0.6%], the United States [kana-mycin; 0.1% and tetracycline; 0.1%], Morocco [polymyxin B; 12%], and Spain [trimethoprim; 0.3%]. Conversely, the highest resistance rates were found in Spain [amoxicillin; 61%], Indo-nesia [kanamycin and tetracycline; 94.9%], India [polymyxin B; 97.8%], and Morocco [trime-thoprim; 48.9%].

Conclusion:

The meta-analysis showed significant variability in antibiotic resistance patterns among environmental NOVC isolates across time and regions, emphasizing the need for tar-geted, time-specific, and country-specific approaches to address antibiotic resistance globally.