bluuebunny/crossref_metadata_2025 huggingface dataset:
High-performance, Wind-driven Triboelectric-Electromagnetic Hybrid Nanogenerator for Self-powered Wireless Transmission and Wind Speed Sensing in the Internet of Things
Authors: Jawahar Dr.C P , Jana Anup Kumar
Published: January 2024

Wind energy is becoming more crucial in addressing the scarcity of fossil fuel due to the development of promising technologies like Electromagnetic Generators (EGs), Triboelectric Nanogenerators (TNs), and their hybrid nanogenerators. However, only a portion of wind energy can be efficiently converted into electricity. By integrating 5G technology with the Internet of Things (IoT) and expanding the deployment of wireless sensor networks, vulnerable areas may be effectively monitored for potential disasters. Nevertheless, substituting conventional chemical batteries with new ones in IoT devices poses a substantial difficulty, particularly in distant regions. This article presents a hybrid energy harvester explicitly designed for wind energy harvesting. This work introduces the High Performance, Wind-driven Triboelectric-Electromagnetic Hybrid Nanogenerator (HPW-TEHN) as a solution for self-powered Wireless Transmission (WT) and Wind Speed Sensing (WSS) in the Internet of Things (IoT). Here, we present a High-Performance Wind Turbine with a wide operational range of wind speeds, allowing for efficient harnessing of wind energy across different levels, including gentle breezes and moderate and severe winds. The gadget comprises a spinning body and a sliding body. The power-producing mechanism consists of the EGs in the rotating body and the TNs in the sliding body. All created units are fully enclosed within the device box, effectively insulated from challenging environmental conditions. This research comprehensively analyzes the impact of dielectric material kinds and sizes on the output performance of TNs. Additionally, it investigates the output performance of this device under various wind speeds. The performance of HPW-TEHN improves as the wind speed increases. At a wind speed of 10 m/s, the TN, EG, and HPW-TEHN generate an output power of 0.19 mW, 0.38 mW, and 1.4 mW, respectively.
To Study the Sustainable Development Practices in Business and Food Industry
Authors: Satpathy Abhilash , Samal Ansuman , Gupta Shalini , Kumar Sunil , Sharma Seema , Manoharan Geetha , Karthikeyan M. , Sharma Samiksha
Published: January 2024

Sustainable development has become an important paradigm in today's society, and companies and industries are increasingly recognizing the need to integrate environmental, social and economic considerations into their business operations. This change is particularly evident in the food industry, where issues of resource depletion, environmental degradation and social responsibility are paramount. This paper engages in the study of sustainable development practices in both the broader business context and the specific area of the food industry, and considers the challenges, opportunities, and transformative initiatives that characterize this evolving landscape.
Precise diagnosis and treatment for peripheral T-cell lymphomas: From pathogenic mechanisms to innovative approaches
Authors: Qiu Yuran , Zhao Weili
Published: January 2024

Peripheral T-cell lymphomas (PTCLs) encompass a diverse group of aggressive non-Hodgkin��s lymphomas originating from mature T lymphocytes. Despite their relatively low prevalence compared to B-cell lymphomas, PTCLs pose significant clinical challenges due to their heterogeneity, lack of specific biomarkers, and often poor response to conventional chemotherapies. Unraveling the intricate pathogenic mechanisms underlying PTCLs is pivotal for the development of targeted therapies, which has become a major focus of PTCL research in recent years. It was previously postulated that genomic alterations play a pivotal role in T-cell transformation and lymphomagenesis. Recent multi-omics investigations and functional studies focusing on pathogenic mechanisms have unveiled that in addition to genetic abnormalities, diverse intrinsic and extrinsic mechanisms are implicated in the pathogenesis of PTCLs. In this Review, we provide an overview of the recent advances in the pathogenesis and management of PTCLs, focusing on the current and potential precise diagnosis and treatment based on intrinsic and extrinsic mechanisms. Bioengineering and drug development have enabled the effective modulation of many previously ��undruggable�� targets, which offers the potential to target new biomarkers associated with PTCL pathogenesis. The integration of artificial intelligence (AI) in clinical practice enables a comprehensive framework, merging diverse data sources and clinical context to discover precise biomarkers for personalized medicine. Finally, we present pressing questions and challenges that demand attention and discuss emerging solutions.
Aplicación del costeo basado en actividades (ABC) en la determinación de un índice de calidad del agua
Authors: Juárez-López Félix Susana , Rodríguez-Martínez Rafael , López-Pérez Héctor Manuel , López Pérez Joel , Arenas-Vargas Miguel
Published: January 2024

Durante la década de los 80 el mercado mundial enfrentó cambios en la filosofía de negocios con un enfoque globalizado, apoyado en avances tecnológicos con el propósito de obtener productos competitivos, minimizar costos de producción y responder oportunamente a las necesidades específicas del cliente. Los objetivos de este estudio fueron a) evaluar la aplicación del sistema de costeo por actividades (ABC) en la determinación de costos de un índice de calidad del agua (ICA), y b) comparar sus resultados con el sistema de costos tradicional (SCT). Se compararon la metodología de ABC y SCT, incluyendo los componentes técnicos (CT) y componentes profesionales (CP), en un periodo de 12 meses. Se encontró que, en el costo total, nueve de los 20 parámetros estuvieron sobrevaluados por el SCT y los 11 restantes se encontraron subvalorados. En el periodo estudiado, los CP se apreciaron sobrevaluados en 12 de los 20 parámetros y en los ocho restantes fueron subvalorados por SCT. Así mismo, los CT estuvieron sobrevaluados en nueve de los 20 parámetros, y los restantes 11 se encontraron subvalorados por SCT. Los resultados obtenidos permiten señalar que el ABC es aplicable a las pequeñas empresas del sector servicios, ya que representa un método más preciso que el SCT para la determinación de los costos de la empresa estudiada.
Leverage Memoderasi Pengaruh Pengungkapan Corporate Social Responsibility (CSR) dan Kepemilikan Manajerial terhadap Nilai Perusahaan
Authors: Romadhoni Risnawati , Asna Asna , Firdaus Riril Mardiana , Puspitosari Arien Anjar
Published: January 2024

Penelitian ini bertujuan untuk menganalisis dan menguji terkait efek pengungkapan Corporate Social Responsibility (CSR) dan kepemilikan manajerial bagi nilai perusahaan dengan leverage berperan sebagai moderasi pada perusahaan manufaktur sub sektor garmen dan tekstil yang tercatat di Bursa Efek Indonesia (BEI) tahun 2018-2021. Jenis riset ini adalah penelitian kuantitatif. Teknik penyaringan sampel adalah purposive sampling dengan 13 perusahaan berhasil memenuhi kriteria. Analisis statistik deskriptif dan analisis statistik memakai alat analisis SmartPLS 3. Hasil dari kajian ini sebagai berikut : (1) CSR tidak memengaruhi nilai perusahaan, (2) Kepemilikan manajerial tidak memengaruhi nilai perusahaan, (3) Leverage memengaruhi nilai perusahaan, (4) Leverage berhasil memoderasi pengungkapan CSR pada nilai perusahaan, (5) Leverage tidak berhasil memoderasi kepemilikan manajerial pada nilai perusahaan.
Las cuestiones fundamentales de «El corazón de Heidegger» y su papel en la obra de Byung-Chul Han
Authors: Morán Roa Alberto
Published: January 2024

El corazón de Heidegger: el concepto de «estado de ánimo» de Martin de Heidegger, de reciente traducción al español, proporciona valiosas claves para la comprensión y el estudio de la obra de Byung-Chul Han en el ámbito hispanohablante. En este artículo expondremos cómo este texto arroja luz sobre las bases filosóficas de Han, la constitución de su proyecto de relación con la alteridad, el marco fenomenológico en el que origina y el imprescindible papel de Martin Heidegger en su pensamiento. Del mismo modo, contribuye a identificar las etapas de su recorrido, así como los cambios experimentados en sus propuestas.
Una aproximación a la intuición estética en Schopenhauer y Bergson
Authors: Zimmermann Clara
Published: January 2024

En este artículo buscamos mostrar que, tanto en la filosofía de Schopenhauer como también en la de Bergson, la experiencia estética se constituye como el paradigma del conocimiento intuitivo. A diferencia de lo que establece la teoría kantiana, para Schopenhauer y Bergson la intuición no sólo es la única forma de conocimiento inmediato, sino que no necesita de conceptos para aprehender aquello dado en la sensibilidad. Asimismo, puesto que actualmente no encontramos demasiada literatura sobre la influencia de Schopenhauer en la filosofía de Bergson, dicho análisis pretende contribuir al establecimiento de los posibles vínculos entre ambas teorías.
¿Generatividad o historicismo? Noticia y comentario sobre el libro Mundo familiar y mundo ajeno. La fenomenología generativa tras Husserl, de Anthony J. Steinbock.
Authors: Álvarez Rubio Juan José
Published: January 2024

Noticia y comentario sobre generatividad e historicismo a propósito de la reciente publicación del libro Mundo familiar y mundo ajeno. La fenomenología generativa tras Husserl de Anthony J. Steinbock, Salamanca, Sígueme, 2022, 429 pp.
Consumo máximo de oxígeno y eficiencia muscular en futbolistas juveniles no profesionales y adultos profesionales
Authors: Segales Dulce , Cofre-Bolados Cristian , Tuesta Marcelo , Farias-Valenzuela Claudio
Published: January 2024

Soccer has been described as a maximal and/or near-maximal effort sport, layered on a low to moderate intensity exercise base. The available evidence suggests that adult male soccer players cover approximate distances of 10 to 12 km during a match and 8.1 km for youth players. The objective of the study is to compare the maximum aerobic power parameters of professional soccer players and youth players. A cross-sectional correlational descriptive study was carried out, 52 adult soccer players and 57 youth soccer players participated. The results reported that the absolute maximum VO2 does not present a significant difference between adults vs juveniles; The relative maximum VO2 in ml/kg-min presents a significant difference in favor of the Juveniles; The maximum aerobic speed in km/h presents a significant difference in favor of the adults and the muscular efficiency in percentage presents a significant difference in favor of the adults. In conclusion, adult professional soccer players have an absolute maximum VO2 similar to youth soccer players; relative oxygen consumption is higher in young soccer players; but the maximum aerobic speed and muscular efficiency are once again higher in adult soccer players.

El fútbol ha sido descrito como un deporte de esfuerzos máximos y/o casi máximos, superpuestos sobre una base de ejercicios de baja o moderada intensidad. La evidencia disponible sugiere que los futbolistas masculinos adultos cubren distancias aproximadas de 10 a 12 km durante un partido y 8,1 km en los jugadores Juveniles. El objetivo del estudio es comparar los parámetros de potencia aeróbica máxima de futbolistas profesionales y jugadores juveniles. Se realizó un estudio de tipo descriptivo correlacional de corte transversal, participaron 52 futbolistas adultos y 57 futbolistas juveniles. Los resultados informaron que el VO2 máximo absoluto no presenta diferencia significativa entre adultos vs juveniles; El VO2 máximo relativo en ml/kg-min presenta diferencia significativa en favor de los Juveniles; La velocidad aeróbica máxima en Km/h presenta diferencia significativa en favor de los adultos y la eficiencia muscular en porcentaje presenta diferencia significativa en favor de los adultos. En conclusión, los futbolistas profesionales adultos presentan un VO2 máximo absoluto similar a futbolistas juveniles; el consumo de oxígeno relativo es mayor en los futbolistas jóvenes; pero la velocidad aeróbica máxima y la eficiencia muscular vuelve a ser mayor en futbolistas adultos.
Carga de entrenamiento y variabilidad de la frecuencia cardiaca en una exposición aguda a la hipoxia hipobárica: Estudio de caso
Authors: Nieto-Jiménez Claudio , Espinoza-Salinas A. , Valenzuela Pérez Diego , Sánchez Raimundo , Besomi Manuela
Published: January 2024

Aim: To analyze the control of training load for an acclimatization strategy employed by two amateur athletes (female and male) prior to a successful ascent to 5460 meters. Methodology: Baseline heart rate variability (HRV) measurements were taken for 195 consecutive days. Four blood samples were taken the week before the main event (Pre), pre-ascent (Pre A), post-ascent (Post A), and one-week post-ascent (Post C). Results: Daily morning HRV recordings were useful for monitoring the state of sympathetic-parasympathetic balance in mountaineers prior to tackling training sessions. Both subjects had increased leukocytes and neutrophil levels, exhibiting variations over 60% between pre-A and post-B conditions. Erythrocytes, hematocrit, and haemoglobin decreased after acute exposure to 5460 m, coinciding with changes in platelet levels between both subjects (-3% and -51%). Conclusions: Daily morning and 5-min HRV recordings are a useful way for monitoring the state of sympathetic-parasympathetic balance. Significant changes were observed in some white blood cells.

Objetivo: Analizar el control de la carga de entrenamiento en la estrategia de aclimatación empleada por dos atletas amateur (mujer y hombre) antes de una ascensión exitosa a 5460 metros. Metodología: Durante 195 días consecutivos se realizaron mediciones basales de variabilidad de la frecuencia cardiaca (VFC). Se obtuvieron cuatro muestras de sangre durante la semana previa al evento principal (Pre), inmediatamente antes de la ascensión (Pre A), después (Post A) y una semana de recuperación (Post C). Resultados: Los registros diarios de VFC matutinos parecen ser una forma útil para monitorizar el estado de equilibrio simpático-parasimpático en montañistas antes de abordar las sesiones de entrenamiento. Se observó que ambos sujetos aumentaron sus niveles de leucocitos y neutrófilos exhibiendo variaciones sobre 60% entre las condiciones pre A y post B. Eritrocitos, hematocrito y hemoglobina presentaron tras la exposición aguda a 5460 m disminuciones, lo que coincide con las diferencias porcentuales en plaquetas entre ambos sujetos (-3% y -51%). Conclusiones: Los registros diarios de VFC matutinos y de 5 minutos de duración parecen ser una forma útil para monitorizar el estado de equilibrio simpático-parasimpático. Se observaron cambios significativos en algunas células de la serie blanca.
Between hand-outs and stand-outs: Opportunities for policy support for just green transitions
Authors:   Nordregio, Salonen Hilma
Published: January 2024

The urgency of climate change, economic shifts, and recent energy crises has highlighted the need for the green transition, with a particular focus on Nordic rural areas playing a key role in developing renewable energy. However, there's concern that this transition might increase existing differences between urban and rural areas. Evidence suggests that people in rural regions feel they might be neglected, which could put fair green transitions and the achievement of climate goals at risk. The policy brief from the Just Green Transition in Rural Areas project emphasises the need to involve local communities in green projects to encourage a sense of ownership and fairness. It calls for early community involvement, clear communication, inclusive compensation strategies, recognition of non-monetary benefits, and using the flexibility of rural municipalities to their advantage. As Nordic rural areas face multiple changes, collaboration across different sectors is vital to ensure fairness and effectiveness in green initiatives, potentially making rural areas pioneers rather than followers in the transition.
A study on the current status of the Pacific War underground military facilities in the Gunsan area
Authors:   The Korean Association of University Museums, Jo In-jin , Jo Ye-na , Kim Dong-in
Published: January 2024

Guinning.
Agenda Setting Rencana Pembangunan Jembatan Bangka-Sumatera
Authors: Audia Zilna Monika , Ibrahim Ibrahim , Sarpin Sarpin
Published: January 2024

Penelitian yang berjudul “Agenda Setting pembangunan jembatan Bangka-Sumatera” ini berfokus kepada beberapa kepentingan dari sisi ekonomi, sisi social, dan sisi politik. Metode penelitian dalam penulisan ini yakni penelitian kualitatif deskriptif. Adapun hasil penelitian bahwa Agenda setting merupakan suatu program yang dilakukan pemerintah Bangka Belitung untuk menyelesaikan permasalahan yang terjadi di Bangka Belitung seperti inflasi di Bangka Belitung ini yang menjadi salah satu latar belakang untuk meningkatkan perekenomian di Bangka Belitung dengan memberikan alternative kebijakan seperti membangun Jembatan Bahtera Sriwijaya, dimana Jembatan tersebut sepanjang 13,5 kilometer yang berlokasi di Desa Sebagin Bangka Belitung. Dari memberikan altenative kebijakan, pemerintah daerah Bangka Belitung memberikan tindakan kebijakan seperti memberikan kebijakan dalam pembangunan jangka panjang dengan membuat Peraturan Daerah Rencana Tata Ruang Wilayah (PERDA RTRW). Lalu hasil dari kebijakan tersebut belum bisa terlaksana sebagaimana mestinya karena keterbatasan anggaran karena dalam pembuatan jembatan tersebut membutuhkan anggaran yang sangat tinggi, lalu masyarakat juga masih memikirkan dampak negative dari adanya jembatan itu nanti seperti kriminalitas, budaya dan kecelakaan lalu lintas.  Sejak di lakukan nya uji kelayakan sampai saat ini belum ada proses yang signifikan terhadap jembatan tersebut. Artinya dalam pembangunan di daerah memerlukan agenda setting yang harus meilihat sisi dari kepentingan ekonomi, kepentingan social dan kepentingan politik didalamnya.
MathVenture: Pengembangan alat peraga Matematika guna meningkatkan pemahaman konsep Matematika siswa SD di Karanggumuk 1
Authors: Maharani Mellynda , Fitrianingsih Ihtiara
Published: January 2024

Program kegiatan pengabdian ini bertujuan untuk mengembangkan alat peraga Matematika, yakni "Pohon Penjumlahan" dan "Ular Tangga Matematika," sebagai solusi untuk meningkatkan pemahaman konsep Matematika siswa Sekolah Dasar (SD) di Padukuhan Karanggumuk 1. Permasalahan utama adalah kurangnya pemahaman konsep Matematika di tingkat dasar dan keterbatasan alat peraga yang dapat mendukung pemahaman konsep secara konkret. Melalui pendekatan Research and Development (R&D) dengan menggunakan model ADDIE, kegiatan ini bertujuan mengidentifikasi kebutuhan siswa, merancang, mengembangkan, mengimplementasikan, dan mengevaluasi efektivitas alat peraga yang dirancang. Metode pengabdian melibatkan observasi dan kuesioner terhadap 8 siswa SD kelas 1-6 di Padukuhan Karanggumuk 1. Hasil menunjukkan bahwa alat peraga tersebut berhasil meningkatkan minat belajar serta pemahaman konsep Matematika siswa melalui kegiatan MathVenture Meskipun demikian, evaluasi lebih lanjut diperlukan untuk menyempurnakan tingkat kesulitan soal cerita yang disajikan. Simpulannya, alat peraga tersebut memiliki potensi besar dalam meningkatkan pembelajaran Matematika di lingkungan sekolah dasar, namun memerlukan evaluasi lanjutan untuk kesuksesan jangka panjangnya.
This community service program aims to develop mathematical teaching aids, namely "Addition Tree" and "Mathematical Ladder Snake," as a solution to improve the understanding of mathematical concepts of elementary school students in Padukuhan Karanggumuk 1. The main problem is the lack of understanding of mathematical concepts at the basic level and the limitations of teaching aids that can support the understanding of concepts concretely. Through a Research and Development (R&D) approach using the ADDIE model, this study aims to identify student needs, design, develop, implement, and evaluate the effectiveness of the designed teaching aids. The research method involved observation and questionnaires on 8 elementary school students in grades 1-6 in Padukuhan Karanggumuk 1. The results showed that the teaching aids succeeded in increasing students' interest in learning and understanding of mathematical concepts through MathVenture activities. However, further evaluation is needed to improve the difficulty of the story presented. In conclusion, the teaching aids have great potential in improving mathematics learning in elementary school environments, but require further evaluation for their long-term success.
NEGOCIAÇÃO COLETIVA E EFETIVIDADE DA BARGANHA SINDICAL: O CASO DOS CANAVIEIROS DO NORDESTE
Authors: Garcia Maria de Fátima
Published: January 2024

Versa sobre os efeitos socioeconômicos do processo de negociação coletiva dos canavieiros do Nordeste, mais especificamente dos Estados de Alagoas, Paraíba, Pernambuco, Rio Grande do Norte e Sergipe. Mostra que essa categoria de trabalhadores, não obstante seu baixo nível de escolaridade, ao longo dos últimos 20 anos alcançou invulgar capacidade de organização e mobilização sindical, a partir da qual conseguiu impor-se perante a classe patronal e desencadear um processo de negociação coletiva que perdura até hoje. O poder de barganha desta categoria evidencia-se no conjunto de conquistas salariais e sociais, consolidadas ao longo do período.
Analysis of Garbage Classification and Processing Methods Based on Text Mining Technology
Authors: Tian Yunan , Jiang Ling
Published: January 2024

This article focuses on the current situation of garbage classification and uses text mining technology to explore suggestions for the future development of garbage classification from the perspective of the public. Subsequently, sentiment analysis based online public opinion analysis is used for garbage classification. At the end of the article, based on the above analysis, we draw conclusions on the attention of online public opinion and public sentiment, and propose scientific suggestions for the development of garbage classification from three levels: government, community, and individuals, in order to promote public participation in garbage classification.
Postpartum depression among primigravida mothers in Kabul, Afghanistan
Authors:   Department of Public Health, Noida international university, Uttar Pradesh, india, Jamizada Maria
Published: January 2024

Introduction: Postpartum depression (PPD) is a prevalent mental health issue affecting women post-childbirth, particularly primigravida mothers. This study aims to explore the prevalence and risk factors of PPD among primigravida mothers in Kabul, Afghanistan, a low- and middle-income country with limited research on PPD among primigravida mothers. Materials and Methods: A descriptive cross-sectional study design was employed, and data were collected from 200 primigravida mothers who gave birth in Rabia Balkhi and Malalai Hospitals in Kabul. A structured questionnaire was utilized to gather data on socio-demographic characteristics, PPD symptoms, and risk factors, which were analyzed using descriptive statistics and SPSS. Results: The study findings revealed that 42.5% of the primigravida mothers in Kabul experienced symptoms of PPD according to EPDS scores. This prevalence rate was higher than global estimates and previous studies in high-income countries. Risk factors associated with PPD among primigravida mothers in Kabul included a history of depression or mental health problems (55.5%), job loss or financial difficulties (74.5%), trauma related to natural disasters or war (63%), experiences of physical or verbal abuse (34.5%), lack of social support or feelings of isolation (23%), and difficulties adjusting to motherhood (48.5%). Conclusion: The study highlights the prevalence and risk factors of Postpartum Depression among primigravida mothers in Kabul, Afghanistan, emphasizing the need for interventions to support new mothers' mental health, including prioritizing screening, providing targeted support, and addressing socioeconomic and environmental challenges, through investment in mental health services and public health campaigns.
Prevalence Of Dental Caries Among Primary School Students In Madurai City, Tamilnadu, India
Authors: PL SasiKumar , Bharathi Saravana , Christopher Aarthi , Pandian Palanivel , Raj Manicka , Prabhu Madhan
Published: January 2024

Aim: Dental caries is an important public health issue,influenced by various socio–demographic factors. The occurrence of carious teeth in school children is very much of concern as it will restrict their daily activities at the schools and homes instigating reductant loss of study, work and play hours.Therefore, the present study was aimed to determine the prevalence of dental caries amongprimary and middle school going childrenin Madurai city. Materials & Methods: For this study, an overall of 40 Corporation schools were randomly selected from the Madurai city. About 3380 children aged between 6-10 years were selected from these schools.Assessment of dental caries prevalence was performed using WHO Basic Oral Health Surveys – Oral Health Assessment Form for the Children (2013). Each child was examined in their respective school by dental surgeons. Result: Out of the 3380 school children that wereexamined, 1475 were boys and 1905 were girls.43% school children had dental caries.Prevalence of dental caries was highest among the10-year-old school students (22.70%) and the lowest in 6- year-olds (17.62%). The dominance of dental caries was higher in girls (55.21%) than boys (44.78). Conclusion: The overall prevalence of dental carieswas 43% and it was higher in 10years old when compared to other age groups.Increased prevalence suggeststhat furtherfollow ups and likewise improving the awareness among teachers, parents and students are necessary too.Also, immediate oral health promotion strategies such as an increase in school dental health programmes are recommended.
Should Wine History Have a Post-colonial Future? British Imperial Viticulture and Settler Colonialism
Authors: Regan-Lefebvre Jennifer
Published: January 2024

As the history of wine emerges as a field of scholarly study, scholars may wish to consider the historiographical and theoretical approaches best suited to its study, particularly in regards to recent research into the central role of colonization in the global spread of viticulture. This article gives an overview of some major historiographical approaches to wine history, noting the general absence of overarching discussions of imperialism and colonialism. Then, to illustrate some of the complexities of applying these frameworks, it considers two related stories, and briefly retells them through each of three theoretical lenses. The first story is of the creation and operation of the Burgoyne Company, the major British importer of Australian and South African wine from the 1870s through the 1950s. The second story is of Burgoyne, and others, importing their wine into the Irish market. These microhistories illustrate what is potentially at stake, and what is complicated, in incorporating colonial and post-colonial frameworks into our understanding of wine history.
Editorial: Empirical Research in Reading and Literary Education
Authors: Fajardo Inmaculada , Mínguez-López Xavier , Kalogirou Tzina
Published: January 2024

The empirical studies on literary education and/or literary reading have often been situated on the margins of academia. The presumption of literature as an inexhaustible knowledge has distanced this type of research from the academic sphere, although in recent decades, novel approaches have emerged that have revitalized the discipline.
Afrofuturismo y ficción especulativa en el caribe. Dos casos de estudio
Authors: González Fernández Maielis
Published: January 2024

El siguiente artículo se propone valorar las implicaciones de la aplicación de la etiqueta Afrofuturismo a textos de ficción especulativa producidos en el marco de la literatura caribeña contemporánea. Se examinará la pertinencia de englobar las obras de la literatura norteamericana, o de otras nacionalidades, que se autodenominan o son clasificadas por la crítica como afrofuturistas —nomenclatura surgida en los Estados Unidos, primero, como una manera de agrupar la literatura de ciencia ficción escrita por autores afroamericanos y luego devenida movimiento contracultural y reivindicativo del legado de la diáspora africana en el país norteño—, con obras caribeñas con rasgos afines a los de esta denominación. Se pretende demostrar que las ficciones caribeñas que contienen elementos de las diferentes culturas africanas que llegaron al Caribe producto de la esclavitud, conformarían un movimiento independiente, con sus características particulares y diferenciadas del denominado Movimiento Afrofuturista estadounidense. En pos de comprobar esto se analizarán las novelas Hija de Legbara (2019) de la escritora jamaicano-canadiense Nalo Hopkinson y Habana Undergüater (2021) del autor cubano Erick Mota. De ellas, particularmente interesa cómo intervienen los elementos de las cosmogonías y las religiones de origen africano en la recreación de sociedades distópicas y/o ucrónicas; cómo se construye la noción de identidad caribeña en la diáspora (Hopkinson) y de qué manera se erige el ciberespacio como una dimensión mítica (Mota).
Mecánica cienciaficcional, novum y substratos míticos en la novela caribeña y centroamericana: 'Tikal Futura' (2012) de Franz Galich, 'El indio sin ombligo' (2007) de Rafael Pernett y Morales y 'La mucama de Omicunlé' (2015) de Rita Indiana
Authors: Remón-Raillard Margarita
Published: January 2024

Este trabajo es un estudio cruzado de tres novelas del área Caribe y Centroamericana: Tikal Futura (2012) del guatemalteco-nicaragüense Franz Galich, El indio sin ombligo (2007) del panameño Rafael Pernett y Morales, y La mucama de Omicunlé (2015) de la dominicana Rita Indiana. Analizamos la manera en que se pone en marcha la mecánica cienciaficcional: la conformación de la extrañeza global o de universo y las distintas modalidades de emergencia del novum (Suvin). También estudiamos las distintas maneras en que el substrato mítico perteneciente a las culturas periféricas (autóctonas y afrodescendientes) funcionan como novum dentro del tejido textual. Finalmente, abordamos la dimensión transtextual en los tres textos (haciendo hincapié en la metatextualidad) y la relación de éstos con el “architexto” ciencia ficción
'El futuro llegó hace rato'. Comunidades en cuentos latinoamericanos en cuentos del presente
Authors: Bianchi Paula Daniela
Published: January 2024

En la literatura latinoamericana del presente surgen subjetividades en transformación que habitan territorios fronterizos en crisis. De ese modo, los protagonistas de “Noche de fiesta” de Natalia García Freire (2019), “La furia de las pestes” (2015) de Samanta Schweblin y “Canícula” (2013) de Claudia Hernández abandonan sus modos de vida y hábitos para transitar baldíos ciudadanos en una topografía cercana a la naturaleza, en comunidades con otras especies, abriendo superficies renovadas ante la opacidad de un universo hostil.
Estos textos literarios inscritos en los límites verbales, en los cruces de las tierras y las etnias cambian irrumpiendo la deslegitimación de ciudadanías plenas para ocupar un espacio oscilante entre el amparo y la intemperie. Entonces, ¿qué permanece cuando la tierra arrasada expone el afuera de las pieles y el territorio?
Estas narrativas registran trazos fecundos que nos posibilitan abordar otros modos de vida, otros escenarios (in)vivibles, otras materialidades en la dimensión dérmica, corporal y territorial, otras alteridades que se fundan en el baldío ciudadano y el olvido de aquellos remanentes que permanecen luego del exterminio o de la precaria supervivencia, compartiendo futuros inciertos que se debaten entre lo viviente y lo sacrificial.
Of Black Bodies and Celestial Bodies: Queer Afrofuturism and New Spatialities in Diego Paulino's Negrum3
Authors: Parisi Ariela
Published: January 2024

This essay explores how Brazilian film director Diego Paulino performs activism through his short film Negrum3. I will argue that Negrum3 develops a new epistemology of the black and queer body using analogy and the appropriation of the language of astrophysics and science fiction in response to the current tense political climate and the homophobic policies of the Brazilian right. The different bodies that claim the cinematographic universe of this short film demonstrate a command of Afrofuturistic aesthetics and speculate about queer utopia and black futures. Consequently, the potentialities of the queer and black future that Paulino is presenting in his film are going to be framed within the aesthetic movement of Brazilian Afrofuturism. Moreover, two main theoretical ideas are going to anchor the analysis of the short film. First, I will discuss the film in relation to José Muñoz’s idea of queer utopia: “The future is queerness’s domain. Queerness is a structuring and educated mode of desiring that allows us to see and feel beyond the quagmire of the present.” (2009). Secondly, I will argue that Paulino is working with a new epistemological approach focused on the black queer body and by doing so, his work is aligned with Lucy Sargisson’s theoretical concept of “transgressive utopianism” (2000).
Tiempos mixtos y subjetividades migrantes en los relatos de ciencia ficción neoindigenista de Giovanna Rivero y Alicia Fenieux
Authors: Cortés Correa Macerena
Published: January 2024

En este artículo analizaré las diversas representaciones de sujetos indígenas y no indígenas en un corpus de ciencia ficción de autoras de la región andina, para luego evaluar la pertinencia del membrete “neoindigenista” en estas obras y la posibilidad de introducir otros elementos de análisis a la luz de los Estudios Críticos del Futuro (Reina-Rozo, 2023). Me referiré particularmente a los conceptos de “subjetividades migrantes” (Cornejo Polar, 1993) y “tiempos mixtos” (Rivera Cusicanqui, 2018) como posibles claves de lectura para los cuentos “Pasó como un espíritu” y “Regreso” de Giovanna Rivero (Bolivia) y “La Dorada” (2014) de Alicia Fenieux (Chile).
Indigenismo y neoindigenismo híbridos en Edmundo Paz Soldán: narrativa minera y ciencia ficción
Authors: Montoya Juárez Jesús
Published: January 2024

¿Cuál es el diálogo que la obra de Paz Soldán entabla con la narrativa de temática indígena boliviana? En el presente trabajo voy a tratar de leer la narrativa minera de Edmundo Paz Soldán desde el marco conceptual del indigenismo y el neoindigenismo, etiquetas centrales en el pensamiento literario americano, para tratar de subrayar el costado político y social que cabe leer en su obra, que a mi modo de ver se exacerba en la producción de los últimos años, que trabaja sobre el esqueleto de la ciencia ficción.
Orgullo travesti: formas de la 'hontologie' en 'Las malas' de Camila Sosa Villada
Authors: Maristany Jose Javier
Published: January 2024

Al abordar la obra de Jean Genet, Didier Eribon (2004) analiza el modo en que la imprecación injuriosa inscribe la vergüenza en el cuerpo del individuo designado pero, a su vez, es esta conciencia de la abyección la que proporciona la energía con la cual el injuriado puede erigir una subjetividad minoritaria que exhibe con orgullo. En el curso de esta operación, el autor se sirve de una palabra acuñada por Jacques Lacan, “hontologie” —aproximadamente ‘vergonzología’ en español—.
El objetivo del trabajo es revisar los modos particulares de la vergüenza de la identidad travesti en la “narrativa vivencial” (Arfuch 2007) de la escritora y dramaturga trans Camila Sosa Villada, y el proceso de transformación hacia alguna forma de orgullo. Para esta ocasión, tomaré su novela, que es también una autoficción, ‘Las malas’ (2019). Sin embargo, es importante tener presente para esta tarea, como lo señala Eribon, que abyección y orgullo no forman parte de una síntesis dialéctica, sino que se trata de una coexistencia inestable de contrarios en la cual el elemento negativo, la vergüenza, marca a la persona en todas las situaciones y está siempre allí como su propio pasado.
La protesta política en el cancionero de Joaquín Sabina: análisis de un "no tema" y reflexiones acerca de un compromiso apolítico
Authors: Soto Zaragoza Javier
Published: January 2024

Este artículo se interesa por una dimensión muy poco estudiada de las letras del cantautor español Joaquín Sabina, pues se cuestiona dónde queda en su cancionero una protesta política que resulta un tema clave en la obra de los cantautores españoles de su generación. A partir de ese interrogante, se examinan algunas letras de Inventario (1978), su primer álbum y por tanto el más próximo a la época de la canción protesta, para comparar su actitud con la de estos otros cantautores. Posteriormente, se presta atención al resto de su cancionero para descubrir cómo la inclinación por el compromiso político se perdió pronto. Por último, se explica que el compromiso en el cancionero de Sabina está más relacionado con la defensa, a través de su representación, de la vida que se inauguró en España tras el fin de la dictadura franquista.
Antes de lo trans
Authors: Peralta Jorge Luis , Huard Geoffroy
Published: January 2024

Presentación del monográfico
Futurismo afrolatinoamericano y poshumanismo indigenista en la ciencia ficción latinoamericana
Authors: López Pellisa Teresa
Published: January 2024

Presentación del monográfico: “Futurismo afrolatinoamericano y poshumanismo indigenista en la ciencia ficción latinoamericana”
Binding and sequestration of poison frog alkaloids by a plasma globulin
Authors: Alvarez-Buylla Aurora , Fischer Marie-Therese , Moya Garzon Maria Dolores , Rangel Alexandra E , Tapia Elicio E , Tanzo Julia T , Soh H Tom , Coloma Luis A , Long Jonathan Z , O'Connell Lauren A
Published: January 2024

Alkaloids are important bioactive molecules throughout the natural world, and in many animals they serve as a source of chemical defense against predation. Dendrobatid poison frogs bioaccumulate alkaloids from their diet to make themselves toxic or unpalatable to predators. Despite the proposed roles of plasma proteins as mediators of alkaloid trafficking and bioavailability, the responsible proteins have not been identified. We use chemical approaches to show that a ~50 kDa plasma protein is the principal alkaloid-binding molecule in blood of poison frogs. Proteomic and biochemical studies establish this plasma protein to be a liver-derived alkaloid-binding globulin (ABG) that is a member of the serine-protease inhibitor (serpin) family. In addition to alkaloid-binding activity, ABG sequesters and regulates the bioavailability of ‘free’ plasma alkaloids in vitro. Unexpectedly, ABG is not related to saxiphilin, albumin, or other known vitamin carriers, but instead exhibits sequence and structural homology to mammalian hormone carriers and amphibian biliverdin-binding proteins. ABG represents a new small molecule binding functionality in serpin proteins, a novel mechanism of plasma alkaloid transport in poison frogs, and more broadly points toward serpins acting as tunable scaffolds for small molecule binding and transport across different organisms.
Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex
Authors: Wagstyl Konrad , Adler Sophie , Seidlitz Jakob , Vandekar Simon , Mallard Travis T. , Dear Richard , DeCasien Alex R. , Satterthwaite Theodore D. , Liu Siyuan , Vértes Petra E. , Shinohara Russell T. , Alexander-Bloch Aaron , Geschwind Daniel H. , Raznahan Armin
Published: January 2024

The cerebral cortex underlies many of our unique strengths and vulnerabilities - but efforts to understand human cortical organization are challenged by reliance on incompatible measurement methods at different spatial scales. Macroscale features such as cortical folding and functional activation are accessed through spatially dense neuroimaging maps, whereas microscale cellular and molecular features are typically measured with sparse postmortem sampling. Here, we integrate these distinct windows on brain organization by building upon existing postmortem data to impute, validate and analyze a library of spatially dense neuroimaging-like maps of human cortical gene expression. These maps allow spatially unbiased discovery of cortical zones with extreme transcriptional profiles or unusually rapid transcriptional change which index distinct microstructure and predict neuroimaging measures of cortical folding and functional activation. Modules of spatially coexpressed genes define a family of canonical expression maps that integrate diverse spatial scales and temporal epochs of human brain organization - ranging from protein-protein interactions to large-scale systems for cognitive processing. These module maps also parse neuropsychiatric risk genes into subsets which tag distinct cyto-laminar features and differentially predict the location of altered cortical anatomy and gene expression in patients. Taken together, the methods, resources and findings described here advance our understanding of human cortical organization and offer flexible bridges to connect scientific fields operating at different spatial scales of human brain research.
β-carotene accelerates the resolution of atherosclerosis in mice
Authors: Pinos Ivan , Coronel Johana , Albakri Asma’a , Blanco Amparo , McQueen Patrick , Molina Donald , Sim JaeYoung , Fisher Edward A , Amengual Jaume
Published: January 2024

β-carotene oxygenase 1 (BCO1) catalyzes the cleavage of β-carotene to form vitamin A. Besides its role in vision, vitamin A regulates the expression of genes involved in lipid metabolism and immune cell differentiation. BCO1 activity is associated with the reduction of plasma cholesterol in humans and mice, while dietary β-carotene reduces hepatic lipid secretion and delays atherosclerosis progression in various experimental models. Here we show that β-carotene also accelerates atherosclerosis resolution in two independent murine models, independently of changes in body weight gain or plasma lipid profile. Experiments in

Bco1
-/-

mice implicate vitamin A production in the effects of β-carotene on atherosclerosis resolution. To explore the direct implication of dietary β-carotene on regulatory T cells (Tregs) differentiation, we utilized anti-CD25 monoclonal antibody infusions. Our data show that β-carotene favors Treg expansion in the plaque, and that the partial inhibition of Tregs mitigates the effect of β-carotene on atherosclerosis resolution. Our data highlight the potential of β-carotene and BCO1 activity in the resolution of atherosclerotic cardiovascular disease.
Using recurrent neural network to estimate irreducible stochasticity in human choice behavior
Authors: Ger Yoav , Shahar Moni , Shahar Nitzan
Published: January 2024

Theoretical computational models are widely used to describe latent cognitive processes. However, these models do not equally explain data across participants, with some individuals showing a bigger predictive gap than others. In the current study, we examined the use of theory-independent models, specifically recurrent neural networks (RNNs), to classify the source of a predictive gap in the observed data of a single individual. This approach aims to identify whether the low predictability of behavioral data is mainly due to noisy decision-making or misspecification of the theoretical model. First, we used computer simulation in the context of reinforcement learning to demonstrate that RNNs can be used to identify model misspecification in simulated agents with varying degrees of behavioral noise. Specifically, both prediction performance and the number of RNN training epochs (i.e., the point of early stopping) can be used to estimate the amount of stochasticity in the data. Second, we applied our approach to an empirical dataset where the actions of low IQ participants, compared with high IQ participants, showed lower predictability by a well-known theoretical model (i.e., Daw’s hybrid model for the two-step task). Both the predictive gap and the point of early stopping of the RNN suggested that model misspecification is similar across individuals. This led us to a provisional conclusion that low IQ subjects are mostly noisier compared to their high IQ peers, rather than being more misspecified by the theoretical model. We discuss the implications and limitations of this approach, considering the growing literature in both theoretical and data-driven computational modeling in decision-making science.
Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Authors: Ouasti Fouad , Audin Maxime , Freon Karine , Quivy Jean-Pierre , Tachekort Mehdi , Cesard Elizabeth , Thureau Aurélien , Ropars Virginie , Varela Paloma F. , Moal Gwenaelle , Amadou Ibrahim Soumana , Uryga Aleksandra , Legrand Pierre , Andreani Jessica , Guerois Raphael , Almouzni Geneviève , Lambert Sarah , Ochsenbein Francoise
Published: January 2024

Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and functions are still a puzzle. While studies of the
S. cerevisiae
CAF-1 complex enabled to propose a model for the histone deposition mechanism, we still lack a framework to demonstrate its generality and in particular, how its interaction with the polymerase accessory factor PCNA is operating. Here, we reconstituted a complete
Sp
CAF-1 from fission yeast. We characterized its dynamic structure using NMR, SAXS and molecular modeling together with
in vitro
and
in vivo
functional studies on rationally designed interaction mutants. Importantly, we identify the unfolded nature of the acidic domain which folds up when binding to histones. We also show how the long KER helix mediates DNA binding and stimulates
Sp
CAF-1 association with PCNA. Our study highlights how the organization of CAF-1 comprising both disordered regions and folded modules enables the dynamics of multiple interactions to promote synthesis-coupled histone deposition essential for its DNA replication, heterochromatin maintenance, and genome stability functions.
Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria
Authors: Dolcemascolo Roswitha , Heras-Hernández María , Goiriz Lucas , Montagud-Martínez Roser , Requena-Menéndez Alejandro , Ruiz Raúl , Pérez-Ràfols Anna , Higuera-Rodríguez R. Anahí , Pérez-Ropero Guillermo , Vranken Wim F. , Martelli Tommaso , Kaiser Wolfgang , Buijs Jos , Rodrigo Guillermo
Published: January 2024

The RNA recognition motif (RRM) is the most common RNA-binding protein domain identified in nature. However, RRM-containing proteins are only prevalent in eukaryotic phyla, in which they play central regulatory roles. Here, we engineered an orthogonal post-transcriptional control system of gene expression in the bacterium
Escherichia coli
with the mammalian RNA-binding protein Musashi-1, which is a stem cell marker with neurodevelopmental role that contains two canonical RRMs. In the circuit, Musashi-1 is regulated transcriptionally and works as an allosteric translation repressor thanks to a specific interaction with the N-terminal coding region of a messenger RNA and its structural plasticity to respond to fatty acids. We fully characterized the genetic system at the population and single-cell levels showing a significant fold change in reporter expression, and the underlying molecular mechanism by assessing the
in vitro
binding kinetics and
in vivo
functionality of a series of RNA mutants. The dynamic response of the system was well recapitulated by a bottom-up mathematical model. Moreover, we applied the post-transcriptional mechanism engineered with Musashi-1 to specifically regulate a gene within an operon, to implement combinatorial regulation, and to reduce protein expression noise. This work illustrates how RRM-based regulation can be adapted to simple organisms, thereby adding a new regulatory layer in prokaryotes for translation control.