bluuebunny/crossref_metadata_2025 huggingface dataset:
Pattern of inappropriate cases presenting to the Accident and Emergency Department in a Nigeria Tertiary Hospital
Authors: Young-Harry Opunabo N. , Dienye Paul O. , Diete-Spiff Kaine O.
Published: November 2022

Background: Although the primary mission of the Accident and Emergency Department (AED) is to provide initial treatment for life-threatening conditions, some patients make inappropriate use of the service. This study is aimed to determine the level of inappropriate use and the morbidity pattern of such patients presenting to the department in a tertiary hospital in Nigeria.Materials and methods: A cross-sectional descriptive study in which inappropriate users of the AED of University of Port Harcourt Teaching Hospital were recruited. Data on socio-demographic characteristics and diagnoses based on ICPC-2 were collected from them and analysed using SPSS version 17.Results: A total of 430 patients were recruited with age range of 18–62 years and mean of 38.45 ± 7.2 years. Considering the socio-demographic characteristics, only the association between gender and utilisation of the AED was statistically significant (p = 0.014). The prevalence of inappropriate use of the AED was 37.7%. The most frequent diagnosis among inappropriate users using the ICPC rubrics was polyuria and glycosuria (9.88%). When the cases were listed by the organ systems according to ICPC chapters, it was found that the commonest diagnoses were gastrointestinal (20.9%) and general and unspecified conditions (17.7%). Psychological conditions were not identified in this study. The most common reason for inappropriately presentation at the AED was patients referring themselves for quick attention (46.3%).Conclusions: The level of inappropriate utilisation of the accident and emergency department was very high in this institution. Creation of public awareness will curtail this sickness behaviour.
From rural scholar to health care professional
Authors: Ross A.
Published: November 2022

Background: International studies have shown that the best strategy for the long-term staffing of rural facilities is the recruitment and training of students of rural origin. However, the crisis in education in South Africa means that these rural students are the least likely to access institutions of higher learning to train as healthcare professionals (HCPs). The aim of this study was to explore the educational experiences of six HCPs of rural origin working in rural areas.Methods: This was a qualitative study using unstructured interviews supplemented by photomemory and collage development. All interviews were transcribed verbatim and themes were developed. Appropriate ethical permission was obtained prior to the study.Results: HCPs of rural origin found the journey from rural scholar to HCP to be tough. Personality characteristics such as tenacity, determination, problem-solving skills, self-belief and hard work were essential for success — but not sufficient on their own. In addition these HCPs needed social support, academic and social mentoring as well as comprehensive financial support.Conclusions: HCPs of rural origin have the potential to provide long-term staffing for rural hospitals. However, if rural healthcare institutions are serious about finding long-term solutions to their staffing challenges, attention needs to be given to finding and appropriately supporting local scholars.
Have we lost the global obesity battle?
Authors: Ogunbanjo Gboyega
Published: November 2022

No abstract available.
Exogenous gonadotropin releasing hormone (GnRH) modulates scrotal and testicular biometrics, libido, endocrinological and heamatological profiles in Ganjam goat under humid tropical coastal ecosystem of Odisha
Authors: Nayak Jibanjyoti , Nahak Anil Kumar , Mishra Purna Chandra , Karna Dillip Kumar , Mishra Chinmoy , Ponraj Perumal
Published: November 2022

Objective:

To assess the effect of exogenous gonadotropin releasing hormone (GnRH) in libido, scrotal and testicular biometrics, endocrinological and heamatological profiles of Ganjam goat buck during winter and pre-monsoon seasons.

Methods:

Forty eight healty Ganjam goat bucks of 3-4 years old were equally divided into the control and treatment groups. The control group received distilled water as placebo, while the treatment group received GnRH injection (4 μg Buserelin acetate/mL) once a week for four months. Body weight, scrotal circumference and testicular parameters (testicular volume, testicular weight and testis index), endocrinological profiles [follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone], sex behavioural profiles (libido score, mating ability score, and sex behavioural score) and heamatological profiles (red blood cells, white blood cells, haemoglobin, and packed cell volume) were estimated.

Results:

The libido, scrotal and testicular biometrics, and endocrinological profiles significantly differed between the control and GnRH-treated bucks within and between the seasons within the two groups (P<0.05). Body weight, scrotal circumference, testicular volume, testicular weight, testis index, FSH, LH, testosterone, libido score, mating ability score, sex behavioural score, red blood cells, haemoglobin and packed cell volume were significantly higher in the GnRH-treated bucks compared to the control bucks in pre-monsoon and winter seasons (P<0.05). Body weight, scrotal circumference, testicular volume, testicular weight, testis index, FSH, LH, testosterone, libido score, mating ability score, sex behavioural score, red blood cell counts (in treatment), and haemoglobin were significantly higher in pre-monsoon compared to winter season in the experimental groups (P<0.05). The white blood cell counts neither differed between seasons nor between the two groups.

Conclusions:

Exogenous GnRH supplementation and pre-monsoon season have higher beneficial effects in improvement of endocrinological profiles with cascading beneficial effects on scrotal circumference, testicular volume, testicular weight, and sex behavioural profiles, which in turn will improve the sperm production and its cryo-survivability and fertility rate in Ganjam goat.
Antibody Response to SARS-CoV-2-Infected Healthcare Workers During First Wave of Covid-19 Pandemic in a Tertiary Care Center of Assam
Authors: Gogoi Gayatri , Medhi Mithu , Nath Reema , Dutta Utpal , Borgohain Mondita , Gohain Binod , Bhattacharyya Neelakshi , Hussain Md Ezaz
Published: November 2022

Context:

Healthcare workers (HCWs) were at the front line of the COVID-19 (corona virus disease-19) pandemic management and were at higher risks of contracting SARS-CoV-2 due to occupational exposure. The objectives of the present study were to estimate the antibody response to SARS-CoV-2 among COVID-19-positive HCWs and its persistence in subsequent follow-up samples and to compare antibody response between rapid antigen/real time polymerase chain reaction (RT-PCR) groups.

Settings and Designs:

This hospital-based cross-sectional study was carried out in Assam Medical College.

Materials and Methods:

Inclusion criteria were SARS-CoV-2 test, which was confirmed in HCWs. A total of 127 HCWs were included. The samples were tested for SARS-CoV-2 IgG by qualitative indirect ELISA using InBios SCoV-2 DetectTM IgG kit. First sample was collected from 25th day to 35th day of SARS-CoV-2. First and second follow-up samples were collected in 3 and 6 months, respectively.

Statistical Analysis Used:

Epi Info version 7 was used. The χ2 test was done.

Results:

A total of 69% male and 31% female HCWs were included. Most of them were in the 20–29 years age group (48%). About 92% were symptomatic and 20% had comorbidities. Overall seroconversion was 88% (RAT category 98.61% and RT-PCR 74.55%). Symptomatic category showed 90.68% seropositivity. The follow-up at the 3rd and 6th month showed 93.85% and 88.24% seropositivity, respectively.

Conclusion:

Rapid antigen test-positive symptomatic people have more chances of development of antibodies within a period of 1 month and sustained for more than 6 months in their blood.
Diagnostic challenges in the management of septic arthritis of the neonatal hip
Authors: Anisi CO , Abang IE , Osakwe OG , Asuquo JE
Published: November 2022

Septic arthritis of the neonatal hip is a very rare pathology. The clinical features may be different from those associated with older children, resulting in diagnostic challenges. Delay in instituting treatment, especially in neonates could be associated with severe dysfunction and deformity in a significant number of affected children. Therefore, treatment should be prompt and comprise broad-spectrum intravenous antibiotic therapy, surgical drainage, and general supportive care. The index patient is a 3-week-old neonate who had left hip arthrotomy on account of septic arthritis. The aim of this report is to highlight the challenges encountered in the diagnosis of septic arthritis of the hip in this patient.
Prolonged complete response after neoadjuvant capecitabine-gemcitabine for a locally advanced pancreatic adenocarcinoma
Authors: Ekwunife CN , Enendu SE , Okorie C , Lemchi S , Nnadi IG , Iwuagwu OC
Published: November 2022

Background:

Pancreatic duct adenocarcinoma is increasing in incidence without appreciable decrease in overall survival despite decades of heightened research. Its mortality rate approaches its incidence rate. We report a case of carcinoma of the pancreas that had complete response from adjuvant chemotherapy.

Case Presentation:

A 39-year old male radiographer presented with a 3-month history of progressively worsening epigastric pain radiating to the back, associated with history of weight loss, anorexia, and jaundice. Abdominal CT scan showed a mass in the head of pancreas. A Whipple's operation was planned for the patient. However, intraoperatively, the head and body of the pancreas were found to have been taken over by the tumor, which encased the portal vein as well. Multiple core needle biopsies of the pancreas were taken. Cholecystojejunostomy, gastrojejunostomy, and jejunojejunostomy were then done. Histopathologic analysis of the specimen revealed a well-differentiated adenocarcinoma of the pancreas. He was commenced on 28-day cycle of gemcitabine 1000 mg/m2 on Days 1, 8, and 15 plus capecitabine 830 mg/m2 on Days 1–14. Repeat CT scan done after the 4th cycle showed no residual tumor in the pancreas. He has been in good health after 36 months follow-up, having received eight cycles of chemotherapy. He was counseled on resection of the pancreas, but he declined.

Conclusion:

Complete radiologic response may rarely occur after adjuvant chemotherapy for locally advanced adenocarcinoma of the pancreas. This does not, however, imply a cure of the disease.
Pulse oximetry and peak expiratory flow rate correlations in acute asthma exacerbation in children
Authors: Onubogu Uchenna Chinweokwu , Ayuk A
Published: November 2022

Background:

The relationship between oxygen saturation (SpO2) and peak expiratory flow rate (PEFR) in patients with acute asthma is variable.

Aim:

This study aims to assess the predictive value and correlation of this relationship in identifying children with mild symptoms of asthma exacerbation and defining their role in guiding early intervention decision-making.

Patients and Methods:

This was a retrospective review of the register of children with asthma seen at the respiratory clinic of a tertiary center in Nigeria from April 2014 to February 2020. Information on their biodata, medical history, clinical status, baseline SPO2, and %predicted PEFR was retrieved and analyzed.

Results:

The mean values for participants with no symptoms and those with mild symptoms of asthma exacerbation were respectively: SpO2 was 97 ± 1.6% and 96 ± 2.6% (MD: 1.2; 95% CI; 0.7–1.7, P < 0.001); %predicted PEFR: 77.8 ± 17.8 and 64.1 ± 23 (MD; 13.68; 95% CI; 7.3 to 20.0, P < 0.001). Among those with uncontrolled asthma who were having mild symptom exacerbation of their asthma, the correlation between SpO2 and %predicted PEFR was significantly moderate (r = 0.44, P = 0.04). Children with SpO2 between the range of 92%–95% were significantly more likely to have mild symptoms of asthma exacerbation (OR: 2.52,95% CI: 1.22, 5.2, P = 0.01) compared to those with SpO2 >95%.

Conclusion:

Children with SpO2 of <95% are more likely to have an acute asthma exacerbation. While SpO2 and PEFR have more role in identifying children without acute asthma exacerbation and a limited role in identifying children with mild symptoms of asthma due to their exacerbation due to their moderate to poor correlation.
Reliability of low-flow anesthesia procedures in patients undergoing laparoscopic cholecystectomy
Authors: Kutlusoy S , Koca E , Aydin A
Published: November 2022

Background and Aim:

The many advantages of low-flow anesthesia are now recognized. Apart from its positive effects on the patient, it is clear that it is a method that all anesthetists should prefer with its positive effects on the ecological balance.

Patients and Methods:

This prospective, observational, cross-sectional study included 80 patients aged 18-65 years with an American Society of Anesthesiologists score of 1-2 (ASA I-II) who were scheduled for laparoscopic cholecystectomy.

Results:

Although the operation time and anesthesia duration were higher in the low anesthesia group group, sevoflurane consumption was lower. Considering the operation times, up to 60% savings were achieved.

Conclusion:

In our study, we safely applied low-flow anesthesia to our patients with advanced monitoring. We believe that low-flow anesthesia is advantageous in terms of both patients' health, ecological balance, and cost.
AI_deation: A Creative Knowledge Mining Method for Design Exploration
Authors: Palamas George , Guerra Alejandra Mesa , Møsbæk Liana-Dorina
Published: November 2022

Ideation is a core activity in the design process which begins with a design brief and results in a range of design concepts. However, due to its exploratory nature it is challenging to formalise computationally. Here, we report a creative knowledge mining method that combines design theory with a machine learning approach. This study begins by introducing a graphic design style classification model that acts as a model for the aesthetic evaluation of images. A Grad-CAM technique is used to visualise where our model is looking at in order to detect and interpret visual syntax, such as geometric influences and color gradients, to determine the most influential visual semiotics. Our comparative analysis on two Nordic design referents suggests that our approach can be efficiently used to support and motivate design exploration. Based on these findings, we discuss the prospects of machine vision aided design systems to envisage concepts and possible design paths, but also to support educational objectives.
Framework for Detection of Fraud at Point of Sale on Electronic Commerce sites using Logistic Regression
Authors: Alabi Bunmi , David Amos
Published: November 2022

Many businesses have been positively impacted by electronic commerce (ecommerce). It has enabled enterprises and consumers transact business digitally and experience diversity as long as the internet is accessible and there is a gadget to surf the internet. Several governments have gradually adopted electronic payment throughout the country. The Nigerian government has also done a lot of prodding toward the adoption of a cashless economy, which includes embracing ecommerce. As ecommerce expands, so does actual and attempted fraud through this channel. According to the Nigerian Central Bank, electronic fraud reached trillions of Naira by 2021. The purpose of this work was to employ logistic regression as a decision-making tool for detecting fraud in e-commerce platforms at either the virtual or physical point of sale. The main contribution of this research is a model developed using logistic regression for detecting fraud at the point of sale on electronic commerce platforms. The accuracy of the result is 97.8 percent. The result of this study will provide key decision makers in ecommerce firms with information on fraud patterns on their ecommerce platforms, this will enable them take quick actions to forestall these fraudulent attempts. Further research should be carried out using data from other developing countries.
Impact of intradialytic hypotension on mortality following the transition from continuous renal replacement therapy to intermittent hemodialysis
Authors: Kim Seong Geun , Yun Donghwan , Lee Jinwoo , Kim Yong Chul , Kim Dong Ki , Oh Kook-Hwan , Joo Kwon Wook , Kim Yon Su , Han Seung Seok
Published: November 2022

Background: The transition of dialysis modalities from continuous renal replacement therapy (CRRT) to intermittent hemodialysis (iHD) is frequently conducted during the recovery phase of critically ill patients with acute kidney injury. Herein, we addressed the occurrence of intradialytic hypotension (IDH) after this transition, and its association with the mortality risk.Methods: A total of 541 patients with acute kidney injury who attempted to transition from CRRT to iHD at Seoul National University Hospital, Korea from 2010 to 2020 were retrospectively collected. IDH was defined as a discontinuation of dialysis because of hemodynamic instability plus a nadir systolic blood pressure <90 mm Hg or a decrease in systolic blood pressure ≥30 mm Hg during the first session of iHD. Odds ratios (ORs) of outcomes, such as in-hospital mortality and weaning from RRT, were measured using a logistic regression model after adjusting for multiple variables.Results: IDH occurred in 197 patients (36%), and their mortality rate (44%) was higher than that of those without IDH (19%; OR, 2.64; 95% confidence interval [CI], 1.70–4.08). For patients exhibiting IDH, the iHD sessions delayed successful weaning from RRT (OR, 0.62; 95% CI, 0.43–0.90) compared with sessions on those without IDH. Factors such as low blood pressure, high pulse rate, low urine output, use of mechanical ventilations and vasopressors, and hypoalbuminemia were associated with IDH risk.Conclusions: IDH occurrence following the transition from CRRT to iHD is associated with high mortality and delayed weaning from RRT.
Multicenter validation of a deep-learning-based pediatric early-warning system for prediction of deterioration events
Authors: Shin Yunseob , Cho Kyung-Jae , Lee Yeha , Choi Yu Hyeon , Jung Jae Hwa , Kim Soo Yeon , Kim Yeo Hyang , Kim Young A , Cho Joongbum , Park Seong Jong , Jhang Won Kyoung
Published: November 2022

Background: Early recognition of deterioration events is crucial to improve clinical outcomes. For this purpose, we developed a deep-learning-based pediatric early-warning system (pDEWS) and aimed to validate its clinical performance. Methods: This is a retrospective multicenter cohort study including five tertiary-care academic children’s hospitals. All pediatric patients younger than 19 years admitted to the general ward from January 2019 to December 2019 were included. Using patient electronic medical records, we evaluated the clinical performance of the pDEWS for identifying deterioration events defined as in-hospital cardiac arrest (IHCA) and unexpected general ward-to-pediatric intensive care unit transfer (UIT) within 24 hours before event occurrence. We also compared pDEWS performance to those of the modified pediatric early-warning score (PEWS) and prediction models using logistic regression (LR) and random forest (RF). Results: The study population consisted of 28,758 patients with 34 cases of IHCA and 291 cases of UIT. pDEWS showed better performance for predicting deterioration events with a larger area under the receiver operating characteristic curve, fewer false alarms, a lower mean alarm count per day, and a smaller number of cases needed to examine than the modified PEWS, LR, or RF models regardless of site, event occurrence time, age group, or sex. Conclusions: The pDEWS outperformed modified PEWS, LR, and RF models for early and accurate prediction of deterioration events regardless of clinical situation. This study demonstrated the potential of pDEWS as an efficient screening tool for efferent operation of rapid response teams.
Target temperature management in traumatic brain injury with a focus on adverse events, recognition, and prevention
Authors: Jo Kwang Wook
Published: November 2022

Traumatic brain injury (TBI) is a critical cause of disability and death worldwide. Many studies have been conducted aimed at achieving favorable neurologic outcomes by reducing secondary brain injury in TBI patients. However, ground-breaking outcomes are still insufficient so far. Because mild-to-moderate hypothermia (32°C–35°C) has been confirmed to help neurological recovery for recovered patients after circulatory arrest, it has been recognized as a major neuroprotective treatment plan for TBI patients. Thereafter, many clinical studies about the effect of therapeutic hypothermia (TH) on severe TBI have been conducted. However, efficacy and safety have not been demonstrated in many large-scale randomized controlled studies. Rather, some studies have demonstrated an increase in mortality rate due to complications such as pneumonia, so it is not highly recommended for severe TBI patients. Recently, some studies have shown results suggesting TH may help reperfusion/ischemic injury prevention after surgery in the case of mass lesions, such as acute subdural hematoma, and it has also been shown to be effective in intracranial pressure control. In conclusion, TH is still at the center of neuroprotective therapeutic studies regarding TBI. If proper measures can be taken to mitigate the many adverse events that may occur during the course of treatment, more positive efficacy can be confirmed. In this review, we look into adverse events that may occur during the process of the induction, maintenance, and rewarming of targeted temperature management and consider ways to prevent and address them.
Using benzyl adenine or coconut water to induce taro sucker and stolon production for increased planting material propagation
Authors: Asante M. O. O. , Yeboah S. , Sarkodie-Addo J. , Danquah E. O. , Frimpong F. , Amoah A.
Published: November 2022

This study evaluated the effect of coconut water and benzyl adenine on the stimulation of corms for stolon and sucker production for increased planting material production. A Randomized Complete Block Design (RCBD) with three replications was used. There were four levels of benzyl adenine (BA): 5 mg L-1/plant, 1.0 mg L-1/plant, 1.5 mg L-1/plant and zero treatment as control; four levels of coconut water (CO): 10 ml/plant; 15 ml/plant; 20 ml/plant and zero treatment as control and two taro varieties; BLSM 80 and BLSM 16. Results showed that the appropriate level of benzyl adenine required for inducing more stolon and sucker production was 1.5 mgL-1. Optimum levels of coconut water required was 15 ml. A multiplication ratio of 1:15 and 1:16 suckers and stolons for CO and BA treatments, respectively was achieved. Planting the suckers in three cycles in a year, a potential of 3,375 or 4,096 stolons and suckers could be generated when the taro is treated with either CO or BA respectively. Benzyl adenine or coconut water can be used to induce many stolons and suckers to generate more planting materials. Farmers who cannot obtain commercially made benzyl adenine can use coconut water for the process.
Prevalence and antimicrobial susceptibility pattern of uropathogenic organisms among diabetic patients attending State Specialist Hospital, Maiduguri Nigeria.
Authors: Madu Wathanafa , Bamaiyi Musa Joseph , Akinola Monilade Tawa , Talle Muhammed , Ibrahim Hamidu M. , Abdullahi Idris Nasir , Mustapha Muhammad , Baba Marycelin Mandu , Oderinde Bamidele Soji
Published: November 2022

Urinary tract infection (UTI) is the colonization of the urinary tract by pathogenic microorganisms. There is paucity of data on the development of multidrug resistant uropathogenic strains associated with Diabetes Mellitus (DM). In this cross-sectional study we investigated a total of three hundred and thirty (330) known diabetes mellitus (DM) patients, comprising of 06 (1.8%) Type I DM, 296 (89.7%) Type II DM and 28 (8.5%) Gestational Diabetes patients aged 21 to 80 years. The subjects consisted of 150 males (45.5%) and 180 (54.5%) females. Urine culture was carried out on CLED, MacConkey and blood agar and Kirby Bauer disc diffusion for antimicrobial susceptibility testing was carried out to determine the susceptibility of the isolated organisms to commonly used antimicrobials in the study area. The study revealed that one hundred and twenty-two (37%) yielded significant bacterial growth. The percentage distribution of the organisms isolated are as follows; Staphylococci (10.6%), Klebsiella spp. (13.2%), Coliforms spp. (13.9%), Staphylococcus aureus (24.6%) and Escherichia coli has the highest occurrence of (37.7%). Gram negative bacteria isolated were highly susceptible to Ciprofloxacin (10 μg), tarivid (10 μg) and streptomycin (30 μg); and moderately- to poorly sensitive to the other antibiotics used in the study. In conclusion female diabetics were at a higher risk for UTIs that than males (p=0.000) and low educational level/social class was also a risk factor (p=0.04) when compared to subjects of higher educational level/ social class.
Sperm parameters and histological changes in testes of cadmium-exposed rats treated with Hibiscus sabdarrifa L. anthocyanins
Authors: Osuvwe Orororo C. , Asagba Samuel O. , Egbune Egoamaka O. , Efejene Ofejiro I.
Published: November 2022

Given increase in infertility due to environmental pollutants, this study examined changes in sperm parameters and testicular histology of cadmium- exposed rats treated with Hibiscus sabdarrifa L. anthocyanins (HSA). Adult male Wistar rats were divided into 9 groups: A (Control), B (Cd), C (HS Aq Extract), D (Low Dose HSA), E (High Dose HSA), F (Low Dose (HSA Pre Cd), G (High Dose HSA Pre Cd), H (Low Dose HSA Post Cd), I (High Dose HSA Post Cd) and treated in two experimental periods (5 days acute toxicity study and 15 days chronic toxicity study). Exposure to Cd alone significantly (p<0.05) reduced sperm volume, motility, morphology and count for both treatment periods compared to the control, and rats administered high and low doses of HSA alone. However, the administration of high and low doses of HSA to Cd-exposed rats significantly altered (p<0.05) these parameters compared to rats exposed to Cd alone. Sections of the testes from control showed several seminiferous tubules disposed within an interstitium composed of interstitial cells of Leydig indicating normalcy. Conversely, section of Rats testes from rats exposed to Cd showed several small sized seminiferous tubules with predominantly roundish architecture indicating great congestion of interstitial blood vessels. The study showed that exposure to Cd induced alterations in sperm parameters and also caused histological changes in the testes of rats. However, the administration of high and low doses of HSA to Cd-exposed rats before and after Cd exposure significantly altered these parameters compared to rats exposed to Cd alone.
Çağdaş sanat izleyicisinin tepkiselliği ve Jens Haaning’in Parayı Al ve Kaç örneği
Authors: DASTARLI Elif
Published: November 2022

Sanatçı Jens Haaning, bir müzenin eski işini yeniden üretmesi isteğini kabul ettikten sonra çalışmaya ayrılan bütçeyi aldı; ancak yeniden üretmeyerek bu üretmeme eyleminin kendisini çağdaş sanat çalışması olarak lanse etti: Parayı Al ve Kaç. Haaning’in eylemi, medyada çağdaş sanatın yeni bir sansasyonu olarak duyuruldu, en sert tepki ise sosyal medya kullanıcılarından geldi; pek çok kişi eylemin sanat olmadığına hükmetti. Yirminci yüzyıl başındaki avangart sanatın tepkiselliğine dayanan bu tür eylemler çağdaş sanatın geniş alanında bir sanat işi olarak uzun süredir kabul görmekte, böylece sanatçılar giderek aykırılık dozu daha yüksek eylemleri yapmaya yönelmektedir. Haaning örneğindeki gibi, hayatın sıradanlığı içinde kolayca yapılabilen eylemlerin sanat olarak sunulmasına insanlar tepki gösterirken sanatçıların amaçlarının ise tam da olabildiğince çok insanın ilgisini çekmek oluşu, bu sanatın üretilmesi ve tüketilmesindeki paradoksal ilişkiyi ele almayı gerektirmektedir. Bu makalede, Haaning’in çalışmasından yola çıkılarak çağdaş sanatın sansasyonel tavrı, sanat-eleştiri arasındaki mesafe ve çağdaş sanat-izleyici ilişkisi tartışılmakta, tepkiselliğin nedenleri saptanarak öneriler getirilmektedir.
ПРЕГЛЕД СРПСКИХ ПРОСВЕТНО-ШКОЛСКИХ ПРИЛИКА У ЈУЖНИМ ОБЛАСТИМА СТАРЕ СРБИЈЕ (1868–1876)
Authors: Арсић Никола
Published: November 2022

Education in Serbia in the southern areas of the Old Serbia is rooted deep into the past and is related to the existence of the Ohrid Archbishopric. With the death of the Serbian prince Mihailo Obrenović in 1868 and the coming to power of the Governorate, the Principality of Serbia set its national work in the Ottoman Empire on new foundations. The revolutionary way of acting was changed to cultural and educational work. The educational and school policy of the Principality of Serbia in the southern areas of the Old Serbia were realized through the Board for schools and teachers in the Old Serbia, Macedonia and Bosnia and Herzegovina, which operated between 1868 and 1876. Thus began the organized action of opening schools, sending teachers, school textbooks and books to those areas, financial assistance to the local church–school municipalities, schools and churches. In the southern areas of the Old Serbia, there were Serbian schools and teachers who worked independently of the Principality of Serbia and its assistance. With the founding of the Bulgarian Exarchate in 1870, education in Bulgaria, using the privileges of Miletus, strongly penetrated the area of southern Old Serbia. Until the outbreak of the Great Eastern Crisis, the Bulgarian Exarchate and the Principality of Serbia were rivals in the struggle for educational and school supremacy in the southern areas of the Old Serbia. Key words: Education–school policy, the Old Serbia, Exarchate, Board for schools and teachers.
ДОКУМЕНТАРНОСТ И ФОТОЖУРНАЛИЗАМ У ПРОМЕНИ ГУТЕНБЕРГОВОГ ДРУШТВА
Authors: Нецић Неда
Published: November 2022

The appearance of photography in 19. century had stopped the fluidity of time and enabled the future generations to have an insight into history. Photographs are a visual testimony of the past and in the period of their occurrence people believed that photographs could provide a true and objective account of reality. Documented war conflicts, people, places and events can enable us an insight into the past. Implementation of photographs into the press gave rise to photojournalism. The press had abundantly used the photography as an illustration to the texts, and the people craved for information and entertainment provided by the press. As the photographic technique evolved, the possibilities of manipulation by means of photography also advanced. With the advancement of media and the photography as a very powerful medium, the people became aware of the possibilities of manipulation by the media. Different examples from history give testimony of how interest groups used the photography with an aim to achieve their political and economic interests. The ethics of these photographs is thus being questioned, since the authentic documentary has often remained marginal. The subject of this study is to give a historical review of photography and its documentary character, and to point out the problems of objectivity, that is ethics of photography since its occurrence till present days.
Respuesta del Sistema de seguridad pública y de justicia a los delitos
Authors: Morales Ixcajó Leonel Humberto
Published: November 2022

OBJETIVO: analizar si el desempeño las cuatro variables disuasorias, aprehensiones, condenas, policías y fiscales, responden con la misma intensidad al incremento de la actividad delictiva durante el periodo de 2002 a 2020 en Guatemala. MÉTODO: a través de un modelo econométrico de vectores autorregresivos de primer orden y un análisis de impulso-respuesta. RESULTADOS: se encontró evidencia empírica que un aumento en los delitos si tiene un impacto estadísticamente significativo en las aprehensiones y las sentencias en un periodo corto de tiempo por los años analizados de 2002 a 2020. Además, que un aumento en las aprehensiones disminuye las sentencias lo que sugiere una saturación del sistema de justicia en la solución de casos. CONCLUSIÓN: los hechos delictivos se dan en función de cómo acontecen las aprehensiones y sentencias, más que en función de quienes las ejecutan de acuerdo a la bondad del modelo, lo que implica que más policías y fiscales no necesariamente representan acciones disuasorias contra el crimen.
CITOKINE RELEASE SYNDROME MANAGEMENT IN ADULTS AND PEDIATRIC PATIENTS
Authors: Garcia Julia Lopes , Rodrigues Kerbauy Fabio
Published: November 2022

Chimeric Antigen Receptor (CAR) T cell therapy has demonstrated efficacy in B cell malignances. However, the treatment is not harmless and, in some patients, can lead to a fatal endpoint. For this reason, the knowledge and the early recognition and management of the side effects related to CAR-T cell therapy for the multidisciplinary team is essential. In this article, we have summarized the current recommendations for identification, gradation and management of cytokine release syndrome related to CAR-T cell therapy.
Lymphodepletion in Cell Therapy
Authors: Paton Eduardo José de Alencar , Duarte Barroso Fernando
Published: November 2022

Chimeric antigen receptor (CAR) T-cell therapy has become a factible therapy for hematologic neoplasms. Prior to infusion, strategies as lymphodepletion and bridge therapy are frequently performed to prolong the persistence of infused cells and increase the effectiveness of the treatment. The aim of this review is to investigate the use of Lymphodepletion and bridge therapy, protocols available, indications, advantages, negative effects, agent associated toxicity, applicability for specific onco-hematological diseases and how to optimize the procedure, guarantying security and efficacy of this approach.
Analysis of the impact of comorbidities in the mortality of patients that were hospitalized with Covid-19
Authors: Lima Verde Ana Teresa Sobreira , Magalhães Chave Ana Vitória , Ceres e Silva Ferreira Lima Yara , Lopes Nassa Yuri , De Oliveira Bringel Marília , Barroso Duarte Fernando
Published: November 2022

Introduction: SARS-CoV-2 has resulted in a pandemic since March 2020. The knowledge of the impact of risk factors is fundamental for its adequate treatment. This study aims to analyze the impact of comorbidities and transplant of solid organs and tissues in patients who were hospitalized because of Covid-19. Methods: There were collected data from 457 patients that had been diagnosed with Covid-19 who were hospitalized in a ward or in an intensive care unit (ICU) at a university hospital. All the patients were sorted for history of transplant of solid organs and tissues. The laboratory results of admission, place of hospitalization and outcome were compared among the group of transplanted and non-transplanted patients. Results: In total, there were collected 457 patient’s data that had been diagnosed with Covid-19. The lethality in our service was 17,94%. The mortality of patients hospitalized in ICUs was 57,14%. The patients that presented hypertension (48,36%) showed a mortality level of 23,53% versus 12,71% who did not. Differently from the previous comorbidity, DM-2 showed no statistical significance. Transplanted patients had 2,13 more chances of being hospitalized in the ICU than in the ward. Also, transplanted patients had 2,21 more chances of death. The mortality in kidney transplant patients was 35.29%, liver transplant was 23.08% and allogenic bone marrow transplant 33.33%. Conclusion: In our sample of patients that had been hospitalized with COVID-19, the prior diagnosis of hypertension and transplant showed higher levels of mortality, mainly kidney transplantated patients (35.29%).
Hematopoietic stem cell transplantation and gut microbiota: outcomes and use of probiotics, a narrative review
Authors: Härter Jéssica , Mariano da Rocha Silla Lucia
Published: November 2022

Hematopoietic stem cell transplantation (HSCT) is a complex procedure used to treat several onco-hematological neoplasms, benign hematological diseases, and some types of solid tumors. In recent years, the role of the gut microbiota in HSCT has been studied, revealing that the microbiota has a direct interaction with the immune system and the microbial balance within the body (eubiosis), providing beneficial health effects, and changes in such state result in dysbiosis, which has been associated with several pathological states. The process in which the patient undergoes HSCT can cause microbiota imbalance with reduced diversity, which would be related to negative post-HSCT outcomes, including increased mortality and development of graft-versus-host disease (GVHD). The modulation of the gut microbiota through methods such as the use of probiotics has been explored as an alternative for the recovery and/or maintenance of the gut microbiota.
Archibald Edward Garrod, la combinación de la práctica clínica con la investigación
Authors: Iglesias Gamarra Antonio , Iglesias Gamarra Antonio , Iglesias Gamarra Antonio
Published: November 2022

Este médico, nacido en 1857, argumentó que la artritis reumatoide era esencialmente una enfermedad de las articulaciones y debía distinguirse claramente del reumatismo.
Climate Change Impacts on Livestock Production: A Review
Authors: AKÇA Büşra , OCAK YETİŞGİN Sezen
Published: November 2022

Livestock production have a major effect on aspect of the environment, especially to climate change. Climate change and its impacts has a widely accepted reality by scholars, and its impact on the environment can clearly be seen. Although global warming impacts will not be felt the same way worldwide, major problems can be avoided by early diagnosis of climate change. Temperature increases have a negative impact on animal production, the performance reproductive, growth, meat and milk yield and quality, health status, and immune response. This review article, the effects of climate change on livestock production and provides so suggestions for productions systems.
Diversity of gastropods in Kapas Island, Indonesia
Authors: Laheng Suardi , Utami Putri Dwi , Wahyui Putri Ika , Miranti
Published: November 2022

Gastropods are one of the constituents of benthic communities in waters and are found throughout the world, ranging from shallow, sandy, coral reefs to deep seas. Gastropods have several advantages, one of the most relevant is that they can be used as bioindicators of pollution. The purpose of this study was to determine the diversity and abundance of gastropods in Kapas Island, Indonesia. This research was conducted for two months on the coast of Kapas Island, Indonesia. Gastropod collection was carried out at 10 observation stations using three transect lines toward the sea and divided into three parts, namely upper intertidal, middle intertidal, and lower intertidal on each transect line. The distance between stations was ~ 150 m. Ninety plots of 1 m2 were set. Abundance and diversity were analyzed qualitatively. Results showed that gastropods consisted of 9 genera and 14 species. Among them, Cerithium sp. had the highest individual abundance (40.15%). The diversity index of gastropods in Kapas Island was 2.07 (medium diversity).
Дефектология. Основы дифференциальной диагностики
Authors: Поникарова В.Н.
Published: November 2022

Основная цель пособия – систематизировать и обобщить материал, формирующий систему знаний у студентов по психолого-педагогическим проблемам дефектологии. Пособие обобщает многолетний авторский опыт в области преподавании дисциплины «Дифференциальная диагностика в системе инклюзивного образования». Пособие содержит конспекты лекций, рекомендуемую литературу, глоссарий, которые раскрывают значение основных терминов, а также практикум с вопросами и заданиями для практических занятий. В пособии излагаются ключевые вопросы и затрагиваются актуальные психолого-педагогические проблемы дефектологии. Акцент при изложении материала сделан на прикладное использование предлагаемой информации. Издание может быть использовано для подготовки студентов (бакалавриат, специалитет, магистратура) и слушателей курсов переподготовки и повышения квалификации специалистов в области дефектологии, специальной и клинической психологии, коррекционной педагогики и девиантологии. Все информация взята из открытых источников.
Wildlife Security and International Relations
Authors: J. Waweru , Kiamba Dr Anita
Published: November 2022

Kenya is endowed with an enormous biodiversity of ecosystems and wildlife species. This rich wildlife together with other attractions has for decades made the country an important tourist destination and hub for the lucrative tourist industry. Nonetheless, wildlife species continue to face threats such as commercial poaching for trophies and human wildlife conflicts that hinder their survival. It is important to mitigate these threats to ensure wildlife species do not go extinct and Kenya continues to pull tourists into the country. The absence of wildlife security poses a threat to international relations. This is because wildlife crimes increase global crime rates that often lead to instability in the global arena. Furthermore, wildlife crime has, throughout history, been a source of funding for rebel groups, militias and extremist groups like the Alshabaab in Somalia. These groups undermine good governance and development efforts of states. This study aims at analyzing the key threats to wildlife security in Kenya and international relations, examining the severity of wildlife threats both locally in Kenya and globally and establishing probable solutions that can be tailor-made to address threats to wildlife security in Kenya and international relations
Life of Javanese women in literature text and the real world
Authors: Ismawati Esti , Amertawengrum Indiyah Prana , Sukini
Published: November 2022

This study explores Javanese women in real life and in old and new Indonesian literary texts. History records how unequal the roles of Javanese women and men are in real life. The method used is structural hermeneutics. The question is how is the relationship between women and men in Javanese society embodied in life and literary texts? Gender and ethnographic approaches with content analysis were used to analyse literary texts as data sources. The main data is in the form of sentence excerpts taken from the text. The view-note-and-engage technique was adopted in data collection. Secondary data were taken from middle-class and upper-class women with in-depth interviews. All data were triangulated with the interpretation of Javanese cultural experts. The results show that women in literature and life play the role of queens such as Ratu Shima, Ratu Kencanawungu, but there are also women who are still confined because of the hegemony of male power such as the character Rapiah in the novel Salah Asuhan. There are also women who play a greater role in the socio-economic field. However, they have not been able to achieve full gender equality. The implication of this research is the need for women to make new history by seizing the role of equality needed in an egalitarian life, by achieving achievements in education, work, and the need for social care for other women and their families .
ANÁLISE DAS EVIDÊNCIAS CIENTÍFICAS ACERCA DA FREQUÊNCIA DE MICRONÚCLEOS EM CÉLULAS DA MUCOSA ORAL EM PACIENTES COM FLUOROSE
Authors: Nunes Vieira Marcelane Índyla , Sousa Pessoa Andrezza , Jorge Carvalho Batista Nelson
Published: November 2022

A fluorose dentária é caracterizada pela hipomineralização do esmalte dos dentes, como resultado da ingestão de flúor por um período prolongado durante o esmalte formação. Este artigo  trata-se de uma revisão bibliográfica qualitativa, através do método revisão integrativa de literatura de publicações selecionadas em bases de dados online onde se deu a elaboração da  pesquisa, nas bases de dados fez-se um levantamento das publicações relevantes ao tema e foram encontrados 7 estudos relevantes para este artigo. No entanto, concluiu-se que o aumento no número   de micronúcleos ficou em mais de 2000 células no grupo diagnosticado com fluorose dentária em relação ao grupo sem fluorose dentária, não houve aumento significativo de outras anormalidades nucleares, além disso, o aumento do uso de cremes dentais contendo flúor aumentou o risco de fluorose dentária em crianças de todas as idades, incluindo a primeira infância.
ENERGIA FOTOVOLTÁICA: SISTEMA ON GRID (SISTEMA CONECTADO À REDE ELÉTRICA)
Authors: Carlos da Silva Elcio , Messias Bruno Danver , Florian Fabiana
Published: November 2022

Este trabalho tem o objetivo de realizar um estudo sobre a viabilidade econômica da geração de energia através do módulo fotovoltaico com o sistema on grid um sistema conectado à rede elétrica residencial. Foi  realizada a pesquisa bibliográfica nas bases Scielo e Google a fim de revisar estudos dos sistemas de energias renováveis. Esta pesquisa se justifica devido à relevância tanto para a sociedade como para profissionais do setor de novas tecnologias ao que se refere a fontes renováveis de energia elétrica para um consumo conciente dos recursos naturais, a fim de informar e trazer conhecimentos de materiais, técnicas e processos para o desenvolvimento deste sistema.
Young Researchers: Guidelines and Limitations in the Russian Scientific Policy (on the example of the first Congress of Young Scientists in Sochi, 2021)
Authors:   Institute of Philosophy and Law of the Siberian Branch of the Russian Academy of Sciences, Lbova E
Published: November 2022

The first Congress of Young Scientists was held on December 8–10, 2021, in Sochi, and bringing together talented young researchers, representatives of business and the Government of the Russian Federation. The event had several objectives: to demonstrate the achievements of Russian science over the past 20 years; outline the prospects for further scientific development; provide a platform for dialogue and interaction between young scientists and officials. Despite numerous efforts aimed at the implementation of the latter task, a constructive dialogue did not take place. However, the topics discussed at the Congress of Young Scientists make it possible to consider the main current directions in the formation of Russian scientific policy towards young researchers.
Hydrodynamics and Sediment Modelling for a Fishery Harbour in Konkan Region of Maharashtra, India
Authors: Sinha Shreya , Shukla V. K. , Singh Ajai
Published: November 2022

Coastal regions are among the most important places for urban development and industrial expansion. However, the system is active and it must be well examined before any infrastructure is planned, to avoid harm from natural processes like degradation, sedimentation, and sometimes sea-generated natural disasters. Numerical modelling of the coast to forecast the area’s natural parameters is an important technique for assessing these systems. Coastal regions are of critical importance to most of the world’s citizens with a significant bearing on economic activities. In the present study, a well-calibrated mathematical model of Vengurla, Maharashtra, has been developed using MIKE 21 flexible mesh software, with the latest prototype data and also carried out 2-D hydrodynamic studies for the proposed 500m breakwater and approach channel. The simulated model will be tangled with the sediment transport model to ascertain the likely pattern of siltation in the area. After studying the Hydrodynamic model, it was observed that in existing conditions, currents varied in the range of 0-0.02 m/sec inside the Vengurla creek and 0-0.15 m/sec in the seawater and currents under the proposed condition varied in the range of 0-0.029 m/sec inside the Vengurla creek and 0-0.22 m/sec in the seawater. No severe circulation or eddies were observed near the beach area in the existing condition as well as in the proposed condition, hence no siltation has occurred in that area. From the sediment model, it was observed that there is not much siltation/erosion after the construction of the proposed breakwater and deepening of the approach channel.