bluuebunny/crossref_metadata_2025 huggingface dataset:
Solubilization of 3-hydroxyquinazoline derivative with antitumor activity
Authors: Sanarova E. V. , Lantsova A. V. , Nikolaeva L. L. , Osipov V. N. , Gusev D. V. , Borisova L. M.
Published: November 2023

Background. Increasing the solubility of new pharmacologically active substances is one of the main tasks of pharmacy. It becomes even more relevant in the field of creating dosage forms for difficult-to-solubilise substances with a new mechanism of action, as in the case of 3-hydroxyquinazoline derivatives, which have shown in vivo experiments the ability to activate tumour cell death by ferroptosis. This includes OVF-009 – an original domestic substance. Due to the solubility of this compound in oils, the technology of its solubilisation using modified castor oil (Kolliphor® ELP, BASF, Germany), approved for parenteral use, was proposed.Aim. To create a model dosage form for a new hydrophobic quinazoline derivative in order to further evaluate the spectrum of its antitumour activity in in vivo experiments.Materials and methods. OVF-009, Kolliphor® ELP, 95 % ethanol, Kollidon 17 PF (BASF, Germany), sodium hydroxide, phosphate buffer, water for injection; spontaneous micelle formation, ultrasound, potentiometry, dynamic light scattering, electrophoretic method, viscometry method, etc.Results. The main properties of micelle-forming solubiliser Kolliphor® ELP and its aqueous solutions were considered; 10 model solutions OVF-009 based only on Kolliphor® ELP and with addition of ethanol and Kollidon 17PF in different concentrations were obtained; the quality of the obtained compositions was evaluated by parameters – appearance, solution transparency, pH, stability over time and tolerability by laboratory animals. As a result, two formulations prepared on phosphate buffer were chosen: formulation No 5, which contains 10 % Kolliphor® ELP and additionally 10 % polyvinylpyrrolidone, and formulation No 8, in which in addition to the main solubiliser 10 % ethanol and 16 % polyvinylpyrrolidone were added. Both formulations have neutral pH, can be stored for 24 h and are tolerated by laboratory animals.Conclusion. The selected model compositions for solubilisation of the substance OVF-009 on the basis of Kolliphor® ELP allowed to provide the concentration of the active substance in the solution suitable for further biological experiments on animals.
Savaşı Dersliklere Taşımak: Akademide Savaş Oyunlarından Nasıl İstifade Edilebilir?
Authors: Baş Mehmet Fatih
Published: November 2023

Savaş oyunları tarihin erken devirlerinden beri dünyanın farklı yerlerinde, farklı şekillerde ortaya çıkmış ve günümüzde kullanılan halini 19’uncu yüzyılın başlarında Prusya’da almıştır. 20’nci yüzyılın ortalarına kadar profesyonel askerî öğretimde ve orduların harbe hazırlık faaliyetlerinde kullanılan savaş oyunları, 1950’lerde askerî tarih temalı hobi oyunlarının yaygınlaşmasıyla akademide kendisini göstermeye başlamış, 1970’lerde akademik maksatlı analitik savaş oyunları oynanmaya başlamıştır. Özellikle 2000’li yıllardan itibaren akademide kısıtlı da olsa kendine yer bulan ve kürsülerde bir ders konusu haline gelen savaş oyunları günümüzde kendi başına bir akademik disiplin olmaya doğru ilerlemektedir. Bu oyunlar özellikle askerî tarih ve uluslararası ilişkiler alanında akademik maksatla git gide daha yoğun biçimde oynanmaktadır. Ancak Türk akademisi çeşitli sebeplerden ötürü savaş oyunlarına yabancı kalmıştır. Buna rağmen savaş oyunlarından Türk akademisinde de istifade edilmesi için girişimlerde bulunulmuş olup, denenmesi halinde olumlu sonuç verebilecek belli yöntemler olduğu görülmüştür. Makalede bu yöntemlerden bahsedilecektir.
The Effect of Fermented Black Soldier Fly (BSF) Addition in Feed on Performance and Digestive Tract Characteristics of Native Chicken
Authors: Nurjannah Bainati , Purwanti Sri , Pakiding Wempie
Published: November 2023

Enhancement amount population and level production native chicken superior need offset with enhancement availability feed For rapid growth and productivity  tall needed enough feed contain substance food needed, good  in a manner quality nor quantity. Black soldier fly (BSF) maggot flour is one of the feed ingredients that is quite good as a potential raw material for poultry feed, because it contains quite high maggot protein, namely 40-50%. The research design used was a completely randomized design (CRD) consisting of 5 treatments and 4 replications. The treatments applied were P0 (100% commercial feed); P1 (100% basal feed); P2 (85% basal feed + 15% BSF fermented); P3 (80% basal feed + 20% BSF fermented), and P4 (75% basal feed + 25% BSF fermented). The Research results show that treatment combination of basal feed with the addition of BSF fermentation influential real (P<0.05) to percentage combination treatment of basal feed with the addition of BSF fermentation, increase body weight, conversion feed and no influential real to drinking water consumption, small intestine morphometric and small intestine histology native chicken. This study concludes that the addition of BSF fermented in the feed up to 20% level able to improve the performance of native chickens in the starter phase.
Ma'nene' Ritual" Ethnographic Study of Ma'nene' Ritual Practices in Toraja
Authors: Putra Ahmad Suthami , Hijjang Pawennari , Tang Mahmud , Badollahi Muh. Zainuddin
Published: November 2023

This research aims to examine the Ma'nene' Ritual Practice in Toraja. This study uses a qualitative method. This research is focused on describing an ethnographic study of the Ma'nene' ritual practice which can be seen from the lives of the Toraja people regarding symbols. The research results show that the existing symbols always have a clear meaning for the Toraja people. Ma'nene' is seen as local wisdom and a culture that is attractive to both the Toraja tribe itself and even people outside Toraja. The Ma'nene' ritual cannot be separated from religious and even social values, so that some of the meanings that must be understood from this article are what people meant by Ma'nene' in the past, namely; (1) Untundan mali'; (2) Unggassa'i pa'kaboro'; (3) Umpamarra' paumpuran; (4) Sometimes old'; (5) Umpaundi polean.
Unlocking the Secrets of Bird Conservation through Ringing: A Review
Authors: Tirthankar Dalui  , Nabajit Mondal
Published: November 2023

Bird ringing, a widely employed technique for marking and studying birds, plays a crucial role in bird conservation. As the human population increases and natural habitats are threatened, birds face numerous challenges that necessitate effective conservation efforts. This paper examines the significance of bird ringing in gathering vital data for conservation and outlines the process and benefits of this technique. Bird ringing provides essential information for understanding bird populations and their behaviours. By capturing and marking birds, researchers can collect data on demographics, habitat usage, feeding patterns, and breeding seasons. Advanced techniques, such as radio-labelled rings, enable tracking of bird movements and migration routes. Through ringing, researchers can examine diseases, assess the presence of microorganisms that may impact both bird and human health and contribute to the understanding of bird-related biosecurity. The process of bird ringing involves careful capture and handling of birds using various techniques tailored to different species and habitats. Rings made of appropriate materials are applied to the birds for identification purposes. Thus, bird ringing is valuable for gathering critical data on bird populations, behaviour, and health, contributing significantly to bird conservation and sustainability. By providing insights into migration patterns, habitat usage, and health status, bird ringing enables conservationists to make informed decisions and implement effective measures to protect bird species and their habitats. Continued research and collaboration in the field of bird ringing are essential for the long-term preservation of avian biodiversity and the maintenance of healthy ecosystems.
Differentiating Mental Stress Levels: Analysing Machine Learning Algorithms Comparatively For EEG-Based Mental Stress Classification Using MNE-Python
Authors: Soumya Samarpita  , Rabinarayan Satpathy  , Bibhu Kalyan Mishra  , Rudra Prasanna Mishra
Published: November 2023

Mental stress is a prevalent and consequential condition that impacts individuals' well-being and productivity. Accurate classification of mental stress levels using electroencephalogram (EEG) signals is a promising avenue for early detection and intervention. In this study, we present a comprehensive investigation into mental stress classification using EEG data processed with the MNE-Python library. Our research leverages a diverse set of machines learning algorithms, including Random Forest (RF), Decision Tree, K-Nearest Neighbors (KNN), Multilayer Perceptron (MLP), Support Vector Machine (SVM), Adaboost, and Extreme Gradient Boosting (XGBoost), to discern differences in classification performance. We employed a single dataset to ensure consistency in our experiments, facilitating a direct comparison of these algorithms. The EEG data were pre-processed using MNE-Python, which included tasks such as signal cleaning, and feature selection. Subsequently, we applied the selected machine learning models to the processed data and assessed their classification performance in terms of accuracy, precision, recall, and F1-score. Our results demonstrate notable variations in the classification accuracy of mental stress levels across the different algorithms. These findings suggest that the choice of machine learning technique plays a pivotal role in the effectiveness of EEG-based mental stress classification. Our study not only highlights the potential of MNE-Python for EEG signal processing but also provides valuable insights into the selection of appropriate machine learning algorithms for accurate and reliable mental stress assessment. These outcomes hold promise for the development of robust and practical systems for real-time mental stress monitoring, contributing to enhanced well-being and performance in various domains such as healthcare, education, and workplace environments
Interpretation of History and Historical Truth in the Samples of Alisher Navoi's Hasbi Hazal
Authors: Shodiyev Fakhriddin  , Namozov Abdimurat  , Rakhimova Gulbakhor  , Gadoyev Oybek
Published: November 2023

This article examines the samples of poetry of Hazrat Alisher Navoi, which are one of the important sources for studying his personal life. Therefore, the poetry of a great poet is an image of his joy, dreams, happy moments, sorrows. Through the experiences of the poet, the spiritual world of a person is known, his feelings, experiences, the world of sadness, joy and desire, philosophical and moral issues worthy of study are imprinted.
Sexual Anarchy Versus Sexual Tranquility- An Insight in the Select Works of Kamala Das
Authors: Sugandha Agnihotri
Published: November 2023

Anglo-Indian Literature is written by Englishmen who are interested in Indian themes and subjects. Indo-Anglian literature and Indian English literature are closely related. Indo-Anglian literature frequently addresses social and domestic themes. It's an English-language genre created by Indian writers. There is a distinction between Indo-Anglian and Anglo-Indian literature. A few contemporary genius authors, like Mulk Raj Anand, R. K. Narayan, Kamala Das, Raja Rao, and Nirad Chaudhuri, are accountable for giving Indo-Anglian literature its specific label, standing, and renown even if it is separate from Anglo-Indian literature. It has been acknowledged that Kamala Das was a pivotal person and voice of her contemporary era. She distinguished and emphasized the Indian identity, setting an example for others to follow rather than copying the techniques of the English modernists. Her poetry is impassioned, energizing, and breaks from the past. Acclaimed for being the most candid and controversial writer, she rose to prominence as the "Voice of Women's Sexuality." Before converting to Islam, she wrote in English under the pen name Kamala Das and published in Malayalam under the pseudonym Madhavikutty. Her bad sexual relationship with her husband, Madhava Das, has been openly discussed, and it is mostly to blame for her notoriety in Kerala.
An Analysis of Novel Writing Styles of Ismat Chugtai
Authors: Deepika Dhand  , Shilpa Wadhwa
Published: November 2023

The research work focuses on analyzing Ismat Chughtai writing styles. From the analysis it was deduced that Ismat used humor in the plots, and casual communications between the novel characters to strike a sarcasm on the societal malpractices with needed instant eradication. The popularity of Ismat Chughtai’s work could be credited to her plain and simple language and the exact representation of the society especially the plight of women in the society post-independence. Chughtai began her writing in the second wave of feminism and therefore she hampered the progress of patriarchy in society. The research work presents vivid aspects of Chughtai’s writing skill and concludes that Chughtai is nothing but a trailblazer of feminism in independent India.
EXTENSIONAL TECTONIC INVESTIGATION BASED ON GRAVITY AND MAGNETIC DATA ANALYSIS IN THE GULF OF TOMINI, INDONESIA
Authors: Handyarso Accep , Permana Haryadi , Hanafi Mustafa , Sendjaja Purnama , Mukti Muhammad Maruf
Published: November 2023

The enigmatic genesis of Sulawesi Island remains a debate among earth scientists up to the present day. The Northern Arm of Sulawesi is designated as a volcanic province, while the Eastern Arm is identified as an ophiolite zone along with several micro continental fragments. However, the tectonic relationship in the marine area between these two arms is not clearly defined. The existence of isolated volcanic islands, namely the Una-Una and Togian islands increases the complexity of the area. A regional study utilizing gravity and magnetic methods is needed in the Gulf of Tomini, North Sulawesi, Indonesia. Therefore, a comprehensive analysis was conducted, involving 3D inverse modelling and Moho depth estimation based on the Parker-Oldenburg algorithm using 3D Euler deconvolution to obtain the average depth of causative bodies. As a result, the presence of extensional tectonics were revealed and identified as multiple parallel dextral strike-slip faults across the study area. All of these faults show northwest-southeast lineaments consistent with the existing seismic sections. The extensional tectonic mechanism triggers crustal thinning and rifting, leading to the build-up of graben structures such as the Gorontalo, Tomini, and Poso basins. Additionally, it influences volcanic activity around the Togian and Una-Una islands. The major axes of the inferred opening area are oriented in the northeast-southwest direction, perpendicular to the lineaments of these faults. The opening area coincides with the orientation of Lalanga and Togian ridges. Finally, a regional geological structure is proposed across the Gulf of Tomini linking both the Northern and Eastern arms of Sulawesi.
SELECTION OF THE MOST PROPER UNDERGROUND MINING METHOD FOR KODAKAN GOLD MINE IN IRAN
Authors: Rahimdel Mohammad Javad
Published: November 2023

The selection of mining methods is a challenging and complicated concept in mining engineering. It depends on various and different factors such as geotechnical, geological and economic properties and characteristics. Kodakan Gold Mine in Iran is currently mined using the open pit method. However, due to the special conditions of this mine and the increase in waste removal costs, it is inevitable to decide to select an underground mining method in the future. The purpose of this research is to select the most proper underground mining method for this mine. The shape, dip, and depth of the deposit, the thickness of the ore, grade distribution, recovery, skilled manpower, output per worker, and strength specifications of the ore, hanging-wall, and footwall are considered as the main decision attributes. Since there are different parameters in selecting the appropriate mining method using the multi-attribute decision making approach, therefore hybrid multi-attribute decision-making method was employed in this paper to enhance the strength of the decision model and eliminate the weaknesses of the classical methods. Regarding the results of this study, rock quality designation of the hanging-wall and deposit shape have the highest weight value in selecting the underground mining method. Moreover, the shrinkage mining method is proposed as the most appropriate method.
APPLICATION OF THE SAP2000 COMPUTER PROGRAMME IN THE MODELLING OF AN UNDERGROUND QUARRY OF DIMENSION STONE
Authors: Mališ Tanja , Hrženjak Petar , Jaguljnjak Lazarević Antonia , Mikulec Mislav
Published: November 2023

A numerical analysis of part of the underground quarry of dimension stone with designed maximum dimensions of the rooms was carried out with the SAP2000 software based on the finite element method. The main objective of the analysis was to examine the preliminary stability and the influence of excavation on the redistribution of stresses in the surrounding rock masses, thus confirming the applicability of the tributary area method. The analytical solution with the tributary area method showed satisfactory agreement with the numerical calculations, and the results of the analytical calculations were on the safe side. The obtained results confirmed the predicted behaviour of the rock mass, which confirms the use of SAP2000 as a general-purpose software for civil engineering in the field of mining. The highest concentrations of stresses and strains are found in the edge areas of the pillars, so their correct design is crucial. The safety factor of the point with the highest stresses was determined and a value of 2.21 was obtained, thus fulfilling the stability condition. As for the influence on the surrounding area, stress changes of less than 10% were determined based on the solutions for the vertical stresses at a distance of 20 m from the underground excavation.
A Validation System for Academic Records based on Blockchain
Authors: Fernández-Blanco Gabriel , Fernández-Caramés Tiago M.
Published: November 2023

Academic certificate forgeries and the lack of resources to tackle them is a problem that implies big costs to society. It harms the figure of the certificates and impairs the trust of academic institutions. The solution proposed in this paper is aimed at recording and verifying the academic merits through a decentralized application or Dapp. Such an application is supported by a smart contract deployed in the Ethereum blockchain with a simple frontend or interface. The application makes use of a decentralized storing system based on IPFS in order to consume the data that are not managed by the blockchain. To assess the performance of the developed system, the latency of its most common operation (read operations) is measured as the number of requests per second increase. The obtained results show that the system is really fast, being some nodes able to respond to more than 1,000 requests in less than one millisecond
Valuation and Risk Modeling of Renewable PPAs
Authors: Pombo Julio , Rúas-Barrosa Oliver , Vázquez Carlos
Published: November 2023

Renewable energy (RE) projects aim to sell electricity to the consumers, which may be carried out by means of a Power Purchase Agreement (PPA). These PPAs will yield payments over a long period of time so as to refinance the project. Nevertheless, the present literature which addresses the economic appraisal of renewable energy projects focuses on the project developer and whether an onsite PPA is deemed, the actual cost of energy is not taken into consideration and nor the embedded options of the PPA.We propose such a model and carry out a comparison with the most common approach, a swap between fixed and market price
Interactive Virtual Reality Public Speaking Training Simulator to Empower Confident Communicators
Authors: Donga João , Gomes Gomes Paulo Veloso , Marques António , Pereira-Loureiro Javier
Published: November 2023

Public speaking is a valuable skill that plays a crucial role in personal, academic and professional success. Many individuals struggle with anxiety and lack confidence when facing an audience. To address this challenge, a virtual reality public speaking simulator has been developed to empower individuals and enhance their public speaking abilities. The virtual reality simulator offers a dynamic platform for immersive practice and training, incorporating distinct modes. Autonomous mode and interactive real-time intervention by physiological biofeedback mechanism and/or a therapist. By leveraging the immersive nature of virtual reality, this simulator aims to boost users confidence, enhance their articulation, persuasion skills and foster their ability to connect with diverse audiences
ESTUDIO PRELIMINAR DE ALGUNOS ASPECTOS AMBIENTALES Y ECOLÓGICOS DE LAS COMUNIDADES DE PECES Y MACROINVERTEBRADOS ACUÁTICOS EN EL RÍO TUTUNENDO, CHOCÓ, COLOMBIA
Authors: Torres Yenecith , Roldán Gabriel , Asprilla Sonia , Rivas Tulia Sofía
Published: November 2023

Entre junio y octubre de 2003 se llevaron a cabo estudios relacionados con aspectos ambientales y ecológicos de las comunidades de peces y macroinvertebrados acuáticos en tres estaciones del río Tutunendo, Departamento del Chocó, Colombia. Se estudiaron algunas características y variables fisicoquímicas como conductividad, pH, oxígeno disuelto y temperatura. Se capturaron 181 individuos distribuidos en tres órdenes, siete familias y doce especies, en su orden Siluriformes [3 familias, 7 especies y 128 especímenes (70.72%)]; Characiformes [3 familias, 3 especies y 43 individuos (23.53 %)]. Los muestreos permitieron recolectar 1211 macroinvertebrados acuáticos distribuidos en los órdenes Ephemeroptera (50.28%), Odonata (11.40%), Coleoptera (8.67%), Hemiptera (8.42%), Trichoptera (7.30%), Plecoptera (5.7%), Megaloptera (3.3%), Lepidoptera (2.31%), Diptera (0.37%) y Haplotaxida (0.08%); las familias Leptophlebiidae (37.24%), Naucoridae (8.42%) y Baetidae (8%) son las más representativas en número de individuos. Se estudió la relación de macroinvertebrados acuáticos y peces mediante la abundancia de presas encontradas en los estómagos de las especies Geophagus pellegrini y Astyanax fasciatus; G. pellegrini, demostró ser zooplanctófaga con preferencia por Baetidae, Leptohyphidae, Hydrobiopsidae, Leptoceridae y Naucoridae. En el Corregimiento de Tutunendo no existen pescadores potenciales; la economía se sustenta en sistemas productivos tradicionales, basados en la agricultura.
SIGNIFICADO BIOLÓGICO DEL EJE HORMONA DE CRECIMIENTO (GH) / FACTOR DE CRECIMIENTO SIMILAR A LA INSULINA (IGF)
Authors: Sánchez de Gómez Myriam
Published: November 2023

La hormona del crecimiento (GH) y los factores de crecimiento similares a la insulina (IGF-I, IGF-II) regulan el crecimiento, la diferenciación, el metabolismo y la expresión génica en múltiples tipos de células a través de mecanismos autocrinos y/o paracrinos, además de la vía endocrina clásica. Este resumen presenta los resultados más significativos obtenidos por el autor y su grupo de investigación en relación con los mecanismos moleculares del eje GH/IGF y sus implicaciones en dos aspectos particulares. En primer lugar, su función como inmunomodulador del estrés nutricional en células linfoides y, en segundo lugar, su papel en el desarrollo de la enfermedad trofoblástica gestacional.
NOVEDADES TAXONÓMICAS Y NOMENCLATURALES EN CREMOSPERMA Y RESIA (GESNERIACEAE) DE COLOMBIA
Authors: Fernández-Alonso José Luis
Published: November 2023

Se describen tres taxones de Gesneriaceae de Colombia: Cremosperma micropecten de la vertiente pacífica del Valle del Cauca y Resia umbratica y R. nimbicola subsp. nemoralis, del centro de Colombia; se propone la combinación nueva Resia bracteata (Skog & de Jesus) Fern. Alonso, y se comentan las afinidades entre las especies del género Resia.
ARISTOLOCHIA GRANDIFLORA SW. (ARISTOLOCHIACEAE): DESARROLLO Y MORFOLOGÍA DE LA FLOR MÁS LARGA DEL MUNDO
Authors: Bello María Angélica , Valois-Cuesta Hamleth , González Favio
Published: November 2023

Aristolochia grandiflora Sw. posee las flores más largas del mundo. La distribución de esta especie incluye México, Centroamérica, Cuba, Jamaica, Colombia, Trinidad y Ecuador, con algunos registros posiblemente procedentes de poblaciones cultivadas o naturalizadas en St. Thomas, Guadalupe y Martinica. Aunque es una especie bien conocida en cultivo, debido a la morfología floral tan extraña y conspicua, es poco conocida en su estado nativo. Además de las dimensiones extremas de la flor, la morfología del perianto es atípica con respecto a las demás especies neotropicales del subgénero Aristolochia, en cuanto a la zigomorfía lateral (i.e. la que modifica el perfil del perianto) y frontal (i.e. la que afecta únicamente al limbo floral), y el desarrollo de dos de las estructuras internas más especializadas, la siringe y el anillo. Se describe el desarrollo floral, con énfasis en el perianto, y se documenta el que sin duda, es el ejemplar con la mayor longitud del perianto hasta ahora conocido en estado silvestre. Finalmente, se discuten las posibles relaciones filogenéticas de la especie.
DESCUBRIMIENTO DE UNA NUEVA ESPECIE DE ATELOPUS (BUFONIDAE) PARA COLOMBIA: ¿UNA LUZ DE ESPERANZA O EL OCASO DE LOS SAPOS ARLEQUINES?
Authors: Acosta-Galvis Andrés R. , Rueda-Almonacid José Vicente , Velásquez-Álvarez Álvaro-A. , Sánchez-Pacheco Santiago J. , Peña Prieto Johann A.
Published: November 2023

Se describe y nombra una nueva especie de anuro del género Atelopus de la Cordillera Oriental de Colombia. Atelopus mittermeieri sp. nov. difiere del resto de las especies del género en la Cordillera por su particular color ventral, rojo encendido. El hallazgo de una población densa y al parecer "saludable" resulta intrigante, ya que de las otras 3 especies registradas en la región no se han presentado observaciones recientes, lo cual hace temer un colapso en sus poblaciones. El reporte de esta nueva especie abre el camino para el estudio y conservación de los sapitos arlequines en Colombia.
Fortalecer balanceo de ecuaciones químicas por medio de una App
Authors: Naranjo-Piedrahita Sergio Poll , Patiño-Bernal Lina Jovana
Published: November 2023

Con base en los resultados de las pruebas Saber Valle 2021, aplicada a los estudiantes de grado décimo de la Institución Educativa Jorge Eliécer Gaitán (IEJEG) del Municipio de Restrepo, Valle del Cauca, en el área de química se identifica que la competencia: de resolución de problemas en balanceo de ecuaciones químicas presenta un bajo desempeño. Por este motivo se busca desarrollar una estrategia que permita a los estudiantes alcanzar un mejor desempeño en esta competencia. Para abordar esta situación, se emplea una investigación descriptiva que consiste en analizar y observar detenidamente el grupo de estudio con el fin de registrar su comportamiento en relación con el objetivo planteado. El propósito es obtener datos que puedan ser organizados y cuantificados, con el fin de superar la dificultad identificada. Este enfoque de investigación se basa en el análisis cuantitativo de las pruebas aplicadas y en los resultados obtenidos. Se utiliza un enfoque descriptivo con un método mixto que incluye observación directa, prueba inicial y final del proceso. El objetivo principal de esta propuesta es contribuir a mejorar el proceso de aprendizaje mediante el uso de MIT INVENTOR 2, una aplicación de fácil acceso y gratuita, que no requiere programas sofisticados en su diseño. Como resultado, se crea la aplicación Lin_Poll, la cual permite alcanzar el objetivo general de la investigación. El desarrollo de esta propuesta pedagógica, basada en el uso de las TIC, promueve el aprendizaje de la competencia de resolución de problemas en ecuaciones químicas. Mediante el uso de la aplicación móvil Lin_Poll, se logra un aprendizaje significativo, como se evidencia en los resultados positivos obtenidos en la prueba final, con un promedio del 74,80%. Esto genera una mayor motivación por parte de los estudiantes hacia el aprendizaje, impulsando un cambio positivo en el proceso educativo.
Estado nutricional e condições clínicas de saúde de pessoas idosas em atendimento público domiciliar
Authors: Gomes Jéssica Raissa Carlos , Garcia Túlia Fernanda Meira , Sousa Layanne Cristini Martin , Garcia Ligia Rejane Siqueira
Published: November 2023

A avaliação de uma pessoa idosa que necessite de atendimento domiciliar na Atenção Primária à Saúde considera sua condição clínica, grau de perda funcional e dependência para a realização das atividades de vida diária. O objetivo do estudo foi avaliar indicadores do estado nutricional e condições clínicas da pessoa idosa acamada em um município do Rio Grande do Norte. Trata-se de estudo transversal, observacional e descritivo, em que foram incluídos idosos de ambos os sexos, na condição de acamados em domicílio e acompanhados pela Atenção Básica. A coleta de dados foi realizada no domicílio mediante entrevista e aferições antropométricas. Participaram do estudo 33 idosos, com média de 82,9 ± 10,3 anos e prevalência do sexo feminino (63,6%), analfabetismo (51,5%), baixo nível socioeconômico (69,7%), desnutrição (69,7%), déficit de massa magra (69,7%), longo tempo na condição de acamado (45,5%), polifarmácia (36,4%), dependência de cuidador (100%) e baixo contato com equipe de saúde multiprofissional (87,1%). Verificou-se grave comprometimento do estado nutricional e das condições clínicas dos idosos acamados. Os resultados desse estudo podem auxiliar no planejamento de ações por parte da atenção domiciliar para melhorar o quadro clínico dos idosos assistidos.
Melhores práticas de enfermagem para a pessoa idosa em Unidades de Estratégia Saúde da Família em um município do Sul do país
Authors: Freitas Maria Alice , Alvarez Ângela Maria , Santos Stefani Aparecida dos , Holz Eduardo Mendes
Published: November 2023

Objetivo: compreender as melhores práticas de enfermagem desempenhadas na Atenção Primária à Saúde em unidades de Estratégia Saúde da família em um município da região Norte do Estado de Santa Catarina. Método: pesquisa qualitativa realizada no município de Joinville-SC por meio de entrevistas semiabertas e individuais. Resultados: Participaram da pesquisa 30 enfermeiros atuantes na atenção primária. Descrevem as melhores práticas de enfermagem voltadas à pessoa idosa, com destaque para a resolubilidade das práticas, a priorização do acesso da pessoa idosa, o cuidado ampliado para os familiares, a atuação do enfermeiro frente a situações de negligência e violência contra a pessoa idosa e, ainda, as barreiras para a efetivação das melhores práticas. Conclusão: a qualificação das ações oferecidas as pessoas idosas na atenção primária perpassa questões administrativas, sociais e resolutivas, e exigem que o enfermeiro esteja inserido no território, conhecendo potencialidades e limitações que interferem no planejamento do cuidado. Contudo, somente enfermeiros com autonomia e segurança no saber científico, aliado ao apoio institucional e ambiente adequado, desenvolvem melhores práticas.
Perfil cognitivo e de funcionalidade de idosos comunitários residentes no interior do estado do Amazonas
Authors: Braga Johrdy Amilton da Costa , Prestes Yandra Alves , Santos Alexandre Freitas dos , Oliveira Higor Gregore Alencar , Souza Kaio de , Oliveira Diego Castro de , Checchi Maria Helena Ribeiro De , Leon Elisa Brosina de , Campos Hércules Lázaro Morais
Published: November 2023

O objetivo da pesquisa foi caracterizar o perfil cognitivo de pessoas idosas domiciliadas na zona urbana de uma cidade no interior do Amazonas. Métodos: Estudo transversal, descritivo e observacional realizado com 130 idosos do município de Coari no Amazonas. Aplicou-se um questionário sociodemográfico e ampla avaliação cognitiva utilizando: Mini Exame do Estado Mental (MEEM), Teste de Trilha, Teste de Fluência verbal, Teste de Reconhecimento de Figuras, Informant Questionnaire on Cognitive Decline in the Elderly – IQCODE e a Geriatric Depression Scale (GDS). Resultados: Encontrou-se pessoas idosas de baixa renda e com baixo nível escolar, com sintomas depressivos, percepção visual regular ou péssima, porém sem déficits cognitivos significativos. Conclusão: Os adultos mais velhos deste estudo se encontravam em situação considerada vulnerável, com sintomas depressivos e comprometimento cognitivo importante considerando a função executiva, linguístico-cognitiva e capacidade de aprendizagem.
Perfil cognitivo de idosos domiciliados de uma cidade no interior do Amazonas
Authors: Prestes Yandra Alves , Braga Johrdy Amilton da Costa , Lopes Higo da Silva , Checchi Maria Helena Ribeiro De , Leon Elisa Brosina de , Campos Hércules Lázaro Morais
Published: November 2023

Este estudo tem como objetivo descrever o perfil cognitivo e de funcionalidade de pessoas idosas que participaram de um grupo um treinamento focado em atividades de dupla tarefa, em uma universidade pública. Métodos: Trata-se de um estudo transversal com idosos que apresentam idade > 60 anos de ambos os sexos. Avaliou-se a cognição pelo Mini-Exame do Estado Mental (MEEM), Teste de Trilha, Teste de Fluência Verbal (TFV), Teste de Reconhecimento de Figuras e Informant Questionnaire on Cognitive Decline in the Elderly-IQCODE. A funcionalidade foi avaliada com o Instrumento de Avaliação de Incapacidade (WHODAS II) e o Brazilian Older Americans Resources and Services Multidimensional Functional Assessment Questionnaire (BOMFAQ). Resultados: Foram avaliados 26 idosos, sendo a maioria do sexo feminino 73,1% (19); com idade ? 60 anos. A maioria dos idosos declararam-se aposentados 92,3% (24), analfabetos ou possui menos de 5 anos de escolaridade 76,9% (20). Os participantes obtiveram uma boa pontuação nas avaliações funcionais, já nas de cognição os idosos apresentaram de moderado a grave déficit cognitivo. Nos testes de avaliação cognitiva aplicados verificou-se comprometimento significativo em relação ao desempenho. Conclusão: no que diz respeito ao perfil cognitivo, verificou-se um comprometimento cognitivo preocupante dos idosos avaliados. Quanto à funcionalidade, os idosos ativos obtiveram bons resultados, mostraram ser independentes ou possuir pouca dificuldade na realização de suas atividades cotidianas e não precisam de dispositivo de auxílio de marcha.
Infantile Metachromatic Leukodystrophy: Case Report
Authors: Hamad Salsabeel , Abufara Israa , Zagharneh Safaa , Abureesh Taimaa , W. M. Jobran Afnan
Published: November 2023

Metachromatic Leukodystrophy (MLD) is typically characterized by the accumulation of sulfatide in various organs, including the central nervous system. This accumulation leads to neurological and mental symptoms. A case of a two-year-old male patient with a history of psychomotor retardation, developmental delay, and poor overall performance is reported. The patient’s imaging findings are compatible with Leukodystrophy. The aim of this case report is to identify the clinical presentation and typical MRI features that can help diagnose MLD, even in the absence of an enzyme assay or gene mutation investigation.
Two Cases of Spinal Accessory Neuropathy Due to Muscle Injection of Nandrolone For Bodybuilding
Authors: Khanmoradi Ziba , Zohrabi Kian , Abna Zohreh
Published: November 2023

The accessory nerve is the eleventh cranial nerve that supplies the sternocleidomastoid and trapezius muscles. Injury to the spinal accessory nerve is most commonly caused by medical procedures that involve the head and neck, which causes wasting of the shoulder muscles, winging of the scapula, and weakness of shoulder abduction and external rotation. Here, two cases of spinal accessory neuropathy after injection of trapezius muscle for body building are reported.
Acceptance rate of COVID-19 vaccine among healthcare workers: A systematic review and meta-analysis
Authors: Sahebi Ali , Ghomian Zohreh , Tahernejad Azadeh , Sadeghi Mahdi
Published: November 2023

Background & Aim: Vaccination is the most efficient strategy to tackle the COVID-19 epidemic, and it is important in many ways. Additionally, healthcare workers represent an important vaccine information source for the general population. This systematic review and meta-analysis aimed to evaluate the COVID-19 vaccine acceptance rate among healthcare workers.
Methods & Materials: This study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, and the protocol of this study was registered in PROSPERO with the registration number CRD42023402082. Searches were conducted up to 20 October 2023 in data resources, including PubMed, Scopus, Web of Science, and Google Scholar. The random-effects model was used for meta-analysis, and the I2 index was used to evaluate heterogeneity among studies. The STATA software (version 14) was used for data analysis.
Results: During the initial search, 6132 articles were selected. After the screening, study selection, and quality assessment, 93 studies entered the meta-analysis process, and a total of 196235 healthcare workers were examined. The overall vaccine acceptance rate among healthcare workers was reported as 68.56% (95% confidence interval (CI) =18.7-99.7; I2 = 99.750%; p< 0.001).
Conclusion: The overall acceptance rate of the COVID-19 vaccine in healthcare workers was lower than expected. Also, some determining factors were identified. The analysis of the vaccine acceptance rate and the factors affecting it can help healthcare officials and policymakers with proper healthcare planning.
Fear of COVID-19, stress, anxiety, depression, and insomnia among undergraduate nursing students in Oman
Authors: Maqbali Mohammed Al , Alsaraireh Mahmoud , AlMekkawi Mohamad , Melhem Omar , Bashayreh Ibrahim
Published: November 2023

Background & Aim: The emergence of COVID-19 has created fears, worries, and anxiety among individuals worldwide. This study aimed to describe the prevalence of mental health problems (fear, stress, anxiety, depression, and insomnia) and their contributing factors among undergraduate nursing students in Oman two years after the start of the pandemic.
Methods & Materials: A cross-sectional study was employed for this study. The questionnaire was distributed electronically via Qualtrics® Online survey software. It consisted of items relating to detailed demographics, background history, and standard scales, including the Fear of COVID-19 Scale, the Perceived Stress Scale, the Hospital Anxiety and Depression Scale, and the Insomnia Severity Index.
Results: The sample comprised 548 nursing students. The participants had a mean FVC-19 score of 16.39, with a standard deviation of 6.04. The overall prevalence of stress, anxiety, depression, and insomnia among nursing students was 94%, 70%, 53%, and 38%, respectively. There was a significant relationship between fear of COVID-19 (p < 0.05) and stress, anxiety, depression, and insomnia.
Conclusion: Fear of COVID-19, stress, anxiety, depression, and insomnia pose notable challenges for undergraduate nursing students. Identifying these mental health issues early is crucial as well as introducing preventive and supportive interventions tailored to the specific contributing factors. This is essential to mitigate the potential for more severe psychological consequences among nursing students.
Predictors of prone position use in patients with COVID-19 acute respiratory distress syndrome in intensive care units: A cross-sectional study
Authors: Vásquez Skarlet Marcell , Cortés Olga Lucía , Paipa-Campos María del Pilar , Mójica-Diaz Carolina , Rojas-Castañeda Yudy Andrea , Pulido-Barragán Sandra Patricia , Arias-Portillo Martha Cecilia , Esparza-Bohorquez Maribel , Martínez Natalia , Arévalo-Sandoval Indira Alba
Published: November 2023

Background & Aim: Clinical recommendations for ventilation management in patients with COVID-19 acute respiratory distress syndrome suggest the use of prone position as complementary therapy, however, there is wide variability in its use. The purpose of this study is to identify the predictor factors for using the prone position for patients hospitalized in intensive care units with COVID-19 acute respiratory distress syndrome.
Methods & Materials: A Cross-sectional study was carried out, including adult patients with COVID-19 acute respiratory distress syndrome hospitalized in intensive care units of four hospitals in Colombia. A multiple logistic regression model was constructed in which the main outcome was the prone position in intensive care, and the independent variables included sociodemographic characteristics, history, health status, progress, and treatment.
Results: A total of 473 patients were included in this study; 59.8% (n=283) received prone position therapy within 24-96 hours of hospitalization in intensive care. Out of the total of eligible variables in the logistics-regression model, factors in favor of the prone position were PCR>10mg/L (OR=3.33), private healthcare network (OR=1.99), hypertension (OR=1,76), cough or dyspnea symptoms at intensive care admission (OR=2.69 and OR=1.91), oxygen saturation <90% (OR=1.84). Factors against the prone position were heart disease (OR=0.34), FiO2>50% (OR=0.32), and TP>13 seconds (OR=0.53).
Conclusion: Patients with COVID-19 acute respiratory distress syndrome with a higher probability of prone position in intensive care were those with PCR>10mg/L, cough, dyspnea, and private healthcare network. The predictors identified in this study could help standardize the prone position therapy.
Influence of Change in Organisational Culture on Performance of Employees in Western Circuit Hotels-Kenya
Authors: Florence Auma Odera
Published: November 2023

Purpose: The goal of this study was to assess the influence of change in organization culture on performance of employees in western circuit hotels- Kenya.
Methodology: To collect and analyze data for this study, correlation research design survey was used together with Lewin’s model and Contingency theories of change for theoretical framework. The target population of this study was 585 staff from different levels from which a sample of 116 was drawn. Stratified random sampling was used with level of staff forming basis of strata. Data instruments were tested for validity via exposure to experts and reliability by Cronbach’s Alpha test on pilot data from 12 respondents. Reliability results indicated all three scales reliable at .801, .777 and .825.
Findings: In an aim to identify the influence of change in organization culture on performance of employees within hotels in western tourist circuit Kenya, Regression results showed that change in organization culture had positive influence on employee performance (β=.323) A statistical model accounted for 26.1% of variation in employee performance respectively
Contribution to theory and practice: The newly acquired insights in this study will contribute to the literature on change in organization culture and its impact on performance of employees in hotels. In addition, the results could be of help to management and stakeholders in hospitality industry being a major employer in the country, students pursuing course in hospitality, improving employee performance, loyalty and attitude towards work to realize great overall performance. The study recommends that the organizations become vigilant on activities of culture change.
With Justice for All: A Social History of Disability in America
Authors: Trammell Jack
Published: November 2023

Social history is only one kind of history. Still, it is exactly the type of history that disability demands to be told, especially due to the universality of the disability experience. Doris and Frieda Zames remind us that “handicapism” is the only “ism” we all will experience if we live long enough. Although disability will always arguably be about physical differences (of body, mind, intellect, personality, etc.), its universal nature means that it should logically be the king/queen of identity politics, while it has long been the pauper. This story helps explain why that was and is today, and what America’s unique and sometimes unpleasant role in the story is. This text attempts not just to represent the American experience with disability but the American experience. The further we move away from 1990 and the passage of the ADA, the less that demarcation seems to be distinct and dichotomous, and the more America seems to be an abject case study of identity possibility in flux, placed squarely at the intersection of the rational and irrational, the qualitative and quantitative, the old and new, the individual and collective, and at the nexus of classic liberalism and neomodernism. In fact, the ADA was reauthorized in 2008, an indication of the constructivist nature of disability policy. This book is intended to be useful and informative, whether as a classroom textbook or as a conversation starter on the coffee table. It also uses the unique tools of the social historian to tell the story.
Anita Philipovsky
Authors: Campagnoli Karina Regalio
Published: November 2023

O objetivo deste artigo é discutir alguns aspectos que marcaram o percurso de constituição intelectual da escritora e poetisa Anita Philipovsky, especialmente a partir de sua participação como colaboradora de diversos periódicos e revistas paranaenses, abordando o contexto histórico das três primeiras décadas do século XX. Por meio de uma pesquisa qualitativa de cunho documental, procurou-se compreender as estratégias e ações que Anita fez uso para se inserir no meio editorial dos jornais e demais veículos de comunicação impressos que circulavam neste contexto histórico, consolidando-se como escritora e crítica social. Para isso, mobilizou-se o conceito de gênero, articulando-o às possibilidades de escrita consideradas autorizadas para as mulheres, perpassando os perfis de leitora, escritora e, posteriormente constituindo-se como intelectual engajada na luta pelos direitos das mulheres, enfatizando as questões educacionais. Constata-se que as atitudes e posicionamentos de Anita Philipovsky podem ser compreendidos a partir da conformação de uma rede de sociabilidades e da construção de capital, assim como de alguns habitus que favoreceram sua entrada e circulação em alguns espaços sociais não tão comuns para as mulheres no contexto histórico abordado.
The microbiome and ovarian cancer: insights, implications, and therapeutic opportunities
Authors: Mehra Yogita , Chalif Julia , Mensah-Bonsu Carol , Spakowicz Daniel , O’Malley David M. , Chambers Laura
Published: November 2023

Ovarian cancer is the leading cause of gynecologic cancer death in the United States. Most ovarian cancer patients are diagnosed with advanced-stage disease, which poses a challenge for early detection and effective treatment. At present, cytoreductive surgery and platinum-based chemotherapy are foundational for patients with newly diagnosed ovarian cancer, but unfortunately, most patients will recur and die of their disease. Therefore, there is a significant need to seek innovative, novel approaches for early detection and to overcome chemoresistance for ovarian cancer patients. The microbiome, comprising diverse microbial communities inhabiting various body sites, is vital in maintaining human health. Changes to the diversity and composition of the microbial communities impact the microbiota-host relationship and are linked to diseases, including cancer. The microbiome contributes to carcinogenesis through various mechanisms, including altered host immune response, modulation of DNA repair, upregulation of pro-inflammatory pathways, altered gene expression, and dysregulated estrogen metabolism. Translational and clinical studies have demonstrated that specific microbes contribute to ovarian cancer development and impact chemotherapy’s efficacy. The microbiome is malleable and can be altered through different approaches, including diet, exercise, medications, and fecal microbiota transplantation. This review provides an overview of the current literature regarding ovarian cancer and the microbiome of female reproductive and gastrointestinal tracts, focusing on mechanisms of carcinogenesis and options for modulating the microbiota for cancer prevention and treatment. Advancing our understanding of the complex relationship between the microbiome and ovarian cancer may provide a novel approach for prevention and therapeutic modulation in the future.