bluuebunny/crossref_metadata_2025 huggingface dataset:
Studies on Genetic Diversity and Stress Indices for Salinity Tolerance in Triticum dicoccum
Authors: Malipatil Srivijay S. , Biradar Suma S. , Desai S. A. , Gundlur S. S. , Kumar Rohit , Narayanaswamy Karthik , Vikram T. Harish , Vishwasgowda C.
Published: November 2023

Salinity stands out as a crucial abiotic stress factor that significantly impacts both crop yield and quality. Wheat, considered a moderately salt-tolerant crop, offers a wealth of variability and diversity within its species, presenting an accessible avenue for enhancing wheat's salt tolerance. Consequently, this study investigated the extent of genetic diversity for salt tolerance among sixty Triticum dicoccum germplasm accessions. In both saline and control condition, the genotypes were divided into three and nine separate clusters respectively, showing that there was a significant level of genetic variability among the genotypes by multivariate analysis. It was observed that biomass was the largest contributor (85.19 %) to the divergence in the saline situation. Among the yield parameters under saline condition, tillers per meter followed by thousand-grain weight and spike length were observed to be important. Thirteen genotypes were salt-tolerant, according to the Stress susceptibility index (SSI). The stress tolerance index (STI) was defined as a useful tool for determining the high yield and potential stress tolerance of genotypes. Based on the stress tolerance index, only eight genotypes were said to be tolerant.
Residual Effect of Integrated Nutrient Management to Preceding Maize on Yield of Succeeding Groundnut under Maize-groundnut Cropping Sequence
Authors: Makwana N. D.  , Bhanvadia A. S.
Published: November 2023

A field experiment was conducted at Krishi Vigyan Kendra, Anand Agricultural University, Dahod during the years 2020-21 and 2021-22 to study the effect of integrated nutrient  management in maize-groundnut cropping sequence. The residual effect of INM treatment applied to preceding rabi maize crop was beneficial for increasing growth and yield attributing characters of succeeding summer groundnut crop viz., plant height and number of branches per plant, number of pods per plant, pod yield and haulm yield per hectare as influenced by different treatments. The residual effect of combination of organic and inorganic to preceding   rabi maize crop, application of 75% RDN through inorganic fertilizer + 25% RDN through vermicompost + Bio NPK consortium (M5) produced significantly higher pod and haulm yields which was at par with 75% RDN through inorganic fertilizer + 25% RDN through FYM + Bio NPK consortium in two years of pooled data. Among the levels of RDF, directly applied to summer groundnut, significantly higher yield attribute, pod and haulm yield was recorded with the application of 100% RDF (G1) which was at par with 75% RDF + Bio NP consortium (G2) in two years of pooled experiment data.
Association between Facial, Occlusal and Cephalometric Characteristics of Individuals in Pre-Orthodontic Treatment Phase: A Retrospective Study
Authors: Otoni Rejane Pereira , Viana Chayenne , Ribeiro Giovanna Vanini de Souza Amorim , Silva Larissa Doalla de Almeida e , Neri Anna Marina Teixeira Rodrigues , Silva Ângelo Fonseca , Santos Carolina Carvalho de Oliveira , Fonseca-Silva Thiago
Published: November 2023

Introduction: The study of the prevalence of malocclusion is important for the knowledge of the common occlusal and facial characteristics of a given population, enabling the prevention, treatment and planning of cases with orthodontic needs.

Objective: The aim of the present study was to evaluate the association between facial, occlusal, and cephalometric findings of individuals in the pre-orthodontic treatment phase.

Materials and Methods: This retrospective cross-sectional study was conducted from a sample of 122 orthodontic medical records of patients in the initial phase of orthodontic treatment. Data related to clinical examination, facial analysis, model analysis, radiographic examinations and intra and extraoral photographs were analyzed. Data on facial type, smile classification and aesthetic pleasantness of the face and smile were collected from extraoral photographs. The occlusal findings were analyzed from plaster models. The cephalometric analysis was evaluated from lateral cephalogram of the face. The collected data were tabulated using the SPSS 17.0 for Windows software and the Chi-square, Kruskal, Wallis and Mann-Whitney tests were used to compare the data.

Results: The most prevalent Angle malocclusion was Class II division 1. Statistical association was observed between the variable Angle malocclusion and the following characteristics: facial type, posterior crossbite, anterior crossbite, anterior open bite, overjet, and overbite (p≤0.05). The Kruskal Wallis and Mann-Whitney tests showed that Class II malocclusion was associated with higher PgNB, NAP, ANB, 1-NB, IMPA, Line S-Ls and overjet values (p≤0.05).

Conclusion: It can be concluded that the population studied has a high prevalence of Class II division 1 malocclusions and this condition is associated with facial, occlusal, and cephalometric findings.
HUBUNGAN KNOWLEDGE SHARING BEHAVIOR DAN INDIVIDUAL INNOVATION CAPABILITY
Authors: Aulawi Hilmi , Govindaraju Rajesri , Suryadi Kadarsah , Sudirman Iman
Published: November 2023

This paper is based on an idea that employee’s capability to create innovation is a key factor which will determine company’s ability to survive a tough competition. Some researchers argue that employee’s capability to innovate can be enhanced by improving knowledge sharing activities. Through such activities, knowledge can be shared out, implemented, and developed. Additionally, it stimulates employees to think more critically and creatively so as to create advantageously new knowledge. Therefore, the objective of this paper is to analyze a relationship between employee’s behavioral knowledge sharing and individual innovation capability. This research uses a qualitative analysis and employs a case study of two telecommunication companies. Finally, this paper suggests that behavioral knowledge sharing encompasses an essential role in developing individual innovation capability.

Abstract in Bahasa Indonesia:

Penelitian ini dilatarbelakangi oleh suatu pandangan bahwa kemampuan karyawan untuk selalu menghasilkan inovasi, merupakan faktor kunci bagi suatu perusahaan untuk dapat bertahan dalam kondisi persaingan yang ketat. Beberapa peneliti berpandangan bahwa salah satu upaya yang dipandang efektif dalam meningkatkan kemampuan inovasi karyawan di perusahaan adalah melalui pengembangan aktivitas knowledge sharing (KS), karena melalui aktivitas tersebut, knowledge dapat disebarkan, diimplementasikan dan dikembangkan. Di sisi lain, KS dapat merangsang individu untuk mampu berfikir lebih kritis dan kreatif, sehingga pada akhirnya dapat menghasilkan knowledge baru yang berguna bagi perusahaan. Oleh sebab itu, penelitian ini bertujun untuk menganalisis hubungan antara KS behavior karyawan dengan individual innovation capability. Penelitian menggunakan analisis kualitatif. Melalui case study di dua perusahaan yang bergerak dalam bidang telekomunikasi di Indonesia, diperoleh gambaran bahwa KS behavior berperan dalam mendorong individual innovation capability.

Kata kunci: knowledge sharing behavior dan individual innovation capability.
INOVASI DAN STRATEGI PENCAPAIANNYA
Authors: Ferryanto Liem
Published: November 2023

Innovation is the way of life of any institution to profitably sustain its life. It starts with empathy, the ability to reach outside of ourselves and walk in someone else’s shoes, and optimal implementation of the newly advanced technology. Innovation shows its results through continuously hard working efforts known as "10 Thousand Hours Rule". As world uncertainty creates complexity we, instead of predicting, should therefore anticipate the future by creating and managing real options on contingent projects or elements of alternative optimal strategies. This should reflect into our portfolio strategy.

Abstract in Bahasa Indonesia:

Inovasi merupakan darah bagi suatu institusi untuk bisa hidup berkelanjutan serta menguntungkan. Inovasi berupa penemuan baru secara sistematis yang berawal dari empati, kemampuan untuk melihat dunia melalui mata orang lain, dan pemanfaatan secara optimal kemajuan teknologi yang ada. Inovasi baru menghasilkan buahnya melalui kerja keras, yaitu dengan mengikuti “Aturan 10 Ribu Jam” secara berkesinambungan. Ketidakpastian, interaksi, keterbatasan dan degradasi menciptakan kompleksitas tentang kebutuhan dan solusi di masa depan. Oleh sebab itu daripada meramalkan risiko yang bakal terjadi, kita sebaiknya memasang strategi berupa skenario untuk mereduksi akibat dari risiko masa depan yang tidak kita mengerti. Skenario ini dapat diperoleh lewat penciptaan dan penanganan beberapa pilihan nyata atas semua proyek antisipatif yang ada.

Kata kunci: Inovasi, ketidakpastian dan kompleksitas, aturan 10 ribu jam, paradoks strategi, peta jalan, empati, kerja berkesinambungan.
Advanced Manufacturing Technology Implementation Process in SME: Critical Success Factors
Authors: Rahardjo Jani , Yahya Salleh bin
Published: November 2023

The aim of this paper is to present critical factors that constitute a successful implementation of the Advanced Manufacturing Technologies (AMT) in Small Medium Enterprise (SME). Many large companies have applied AMT and the applications have shown significant results in this global market era. Conveniently, these phenomenons are also engaged to Small Medium Enterprises (SME) that of high demands on performing high quality product, fast delivery, reliable and more flexible. The implementation of AMT follow several processes namely pre installation, installation, improvement and mature. In order to guarantee the succesfull of running these processes, one should consider the Critical Success Factors (CSF). We conducted a survey to 125 SMEs that have implemented AMT, and found that the CSF for each process are moderately different. Good leadership is the main critical success factor for preparing and installation of the AMT. Once the AMT started or installed and arrived at growth stage, the financial availability factor turns into a critical success factor in the AMT implementation. In, mature stage, the support and commitment of top management becomes an important factor for gaining successful implementation. By means of factor analysis, we could point out that strategic factors are the main factors in pre-installation and installation stage. Finally, in the growth stage and mature stage, both tactical and strategic factors are the important factors in the successful of AMT implementation
Production Inventory Models for Deteriorating Items with Stochastic Machine Unavailability Time, Lost Sales and Price-Dependent Demand
Authors: Widyadana Gede Agus , Wee Hui Ming
Published: November 2023

The economic production quantity (EPQ) model is widely employed in reality and is also being intensively developed in the research area. This research tries to develop more realistic EPQ models for deteriorating items by considering stochastic machine unavailability time (uniformly and exponentially distributed) and price-dependent demand. Lost sales will occur when machine unavailability time is longer than the non production time. Since the closed form solution cannot be derived, we use Genetic Algorithm (GA) to solve the models. A numerical example and sensitivity analysis is shown to illustrate the models. The sensitivity analyses show that a management can use price policy to minimize the profit loss due to machine unavailability time under a price- dependent demand situation
THE APPLICATION OF FEATURE TECHNOLOGY IN DEVELOPING A CAD-BASED HIGH LEVEL PROCESS PLANNING SYSTEM
Authors: Febransyah Ade
Published: November 2023

High-level process planning plays an important role in determining candidate process domains at the configuration design stage. Changing the process domains later increases the product development cycle and the product development cost. Therefore, determining the most appropriate manufacturing processes at the beginning stages of the design process becomes critical. However, high-level process planning systems have traditionally lacked integration of design synthesis and design evaluation. The objective of this paper is to propose a CAD-based high-level process planning system that will help designers decide whether or not the designs are worth pursuing. A hybrid approach incorporating design by feature and feature recognition approaches is proposed and implemented. Synergizing both advantages of both approaches will reduce the complexity of feature recognition algorithm without sacrificing the flexibility in creating a part model.
ASSESMENT OF RENEWABLE ENERGY TECHNOLOGIES (SOLAR THERMAL AND WINDMILS)
Authors: Panjaitan Togar Wiliater Soaloon
Published: November 2023

The development of renewable energy technologies (RETs) has moved forward significantly; while the current environmental problems that some attribute to, among others, the combustion of fossil fuels to produce energy has contributed to the attractiveness these technologies. In some instances, governments support RETS and have put in place subsidies to encourage people and companies to implement or use them. Companies have responded to this as it not only brings monetary savings from using energy efficiently but can also be valuable for their image as more and more consumers are becoming environmentally conscious. Many companies have decided to take a similar route and is interested in using RETS and other environmentally friendly technologies to meet its energy requirements. The report has addressed the issue of looking at the technical and financial feasibility of installing some or all of the identified renewable energy technologies (wind energy and solar thermal), and has been structured in line with the following approach. In this report, the following approach/preliminary assessment method based on Investment Costs, O & M Costs, Operational hours/year, Ease of Installation, O&M Procedures, Social Acceptability, Greenness of technology.
PERANCANGAN PENJUALAN DAN PERENCANAAN PRODUKSI YANG TERINTEGRASI DENGAN MENERAPKAN TEKNOLOGI ENTERPRISE RESOURCES PLANNING (Studi Kasus Pada Perusahaan Furniture Consumer Good dan Elektronik)
Authors: Tarigan Zeplin Jiwa Husada
Published: November 2023

Most of enterprises got failed at the first step in implemented ERP. Based on cases study in furniture, consumer goods, and electronic company that already implemented the ERP; the failure happened when they tried to integrate the selling and production planning system and need relatively a long time for implementation. Based on experiences in the field, the successfully of the implementation, really depends on continuous improvement to match between ERP's system and real enterprises demand.

Abstract in Bahasa Indonesia :

Banyak perusahaan mengalami kegagalan pada saat awal mengimplementasikan enterprise resources planning (ERP). Berdasarkan studi kasus pada perusahaan furniture, consumer good dan elektronik yang telah mengimplementasikan ERP, kesulitan yang ditemui adalah dalam mengintegrasikan sistem penjualan dan perencanaan produksi, serta waktu implementasi yang relatif lama. Dari pengalaman di lapangan, keberhasilan implementasi ditentukan oleh perbaikan berkelanjutan untuk menyesuaikan antara sistem ERP dan kebutuhan rill perusahaan.

Kata kunci: ERP, integrasi penjualan dan perencanaan produksi, furniture, consumer good, elektronik.
PEMODELAN PEMROGRAMAN LINIER DENGAN KOEFISIEN FUNGSI OBJEKTIF BERBENTUK BILANGAN KABUR SEGITIGA DAN KENDALA KABUR BESERTA USULAN SOLUSINYA
Authors: Susanto Sani , Suryadi Dedy , Adianto Hari , Aritonang YMK
Published: November 2023

Linear Programming Model consists of one objective function and at least one constraint. The parameters in the objective function are called objective function coefficients. Objective function coefficients represent the contribution of one unit of its corresponding decision variable to the objective function value. The exist objective function as well as its constraints in the linear programming model are characterized as crisp. Such assumptions are often considered as unrealistic. This research models and solves the Linear Programming Model in the case where objective function coefficients are in the form of triangular fuzzy number and the constraints are fuzzy as well.

Abstract in Bahasa Indonesia :

Model Pemrograman Linear (MPL) memiliki sebuah fungsi objektif dan satu atau lebih kendala. Pada fungsi objektif terdapat parameter yang disebut koefisien fungsi objektif (objective function coefficients). Koefisien fungsi objektif menggambarkan kontribusi satu satuan variabel keputusan terhadap nilai fungsi objektif. Koefisien fungsi objektif yang selama ini dikenal dalam pembahasan MPL bersifat tegas (crisp)., demikian pula dengan kendala. Tulisan ini membahas suatu pendekatan terhadap perumusan dan penyelesaian MPL dalam hal koefisien fungsi objektifnya berbentuk bilangan kabur segitiga (triangular fuzzy number) dan kendalanyapun bersifat kabur.

Kata kunci: model pemrograman linear, parameter pemrograman linear, bilangan kabur, koefisien fungsi objektif, bilangan kabur segitiga, kendala kabur.
SERVICE QUALITY CONTROL MEASUREMENT: QUALITOMETRO II METHOD
Authors: Laksimon Rosna , Pribadi Henry
Published: November 2023

High quality of service is imperative for competitiveness of a service industry. In order to provide much better service, a deeper research on quality service is a necessity. One interesting and challenging aspect in researchin service quality is about measuring service quality. While some methods is proposed for measuring service quality, but every one of them did not offer satisfactory explanation in complex problems of measuring service quality, which is the vagueness and incompleteness in transforming linguistic explanation and scale of one's opinion into numerical scale. One interesting method that incorporate the complexity and vagueness of linguistic explanation and scale into consideration is Qualitometro II method. This method will handle information expressed on linguistic scales without any artificial numeric scalarization and measure and control the quality of service. An interesting study of implementation of Qualitometro II in general medical clinic is conducted to examine the operation and impact of the Qualitometro II method with the assistance of a qualitometro software to ease the complex calculation algorithm. Result of the implementation is presented and evaluated for further study.
KERANGKA KERJA PENILAIAN INVESTASI LINGKUNGAN (ENVIRONMENTAL PERFORMANCE APPRAISAL)
Authors: Tambunan Sihar Tigor Benjamin
Published: November 2023

Business sustainability can not depend on the business financial performance merely. Poor environmental performance is believed can contribute negative impact on business sustainability in the long run. To face these environmental problems, Environmental Management Accounting (EMA) tools - especially Materials & Energy Flow Accounting (MEFA)- is used to identify opportunities of environmental performance on a production system that will be solved with application of an environmental investment decision. For better decision, investment decision to improve environmental performance is recommended to consider at least three monetary indicators, NPV, profitability, and Payback Periods, and two environmental indicators, Ecological Advantage Ratio (EAR) and Ecological Payback Period (EPP).

Abstract in Bahasa Indonesia :

Kelangsungan hidup usaha tidak dapat semata-mata bergantung pada kinerja finansial. Kinerja lingkungan yang buruk sebagai dampak keberadaan usaha diyakini dapat memberikan dampak yang buruk pula bagi kelangsungan hidup usaha dalam jangka panjang. Untuk mengatasi masalah lingkungan tersebut, instrumen-instrumen akuntansi manajemen lingkungan (EMA), khususnya diagram alur bahan dan energi (MEFA), digunakan dalam proses pengidentifikasian peluang-peluang perbaikan kinerja lingkungan dalam sebuah sistem produksi yang nantinya akan diselesaikan dengan pembuatan sebuah keputusan investasi lingkungan. Untuk mendapatkan keputusan yang lebih baik, keputusan investasi untuk melakukan perbaikan kinerja lingkungan disarankan setidak-tidaknya memperhatikan tiga indikator moneter yaitu NPV, profitabilitas, dan periode pengembalian (PP) serta dua indikator lingkungan yaitu rasio keuntungan ekologis (EAR) dan periode pengembalian ekologis (EPP).

Kata kunci: EMA, MEFA, EIA, EAR, EPP
Implications of High Tumor Burden on Chimeric Antigen Receptor T-Cell Immunotherapy
Authors: Ventin Marco , Cattaneo Giulia , Maggs Luke , Arya Shahrzad , Wang Xinhui , Ferrone Cristina R.
Published: November 2023

Importance

Chimeric antigen receptor (CAR) T-cell therapy has redefined the therapeutic landscape of several hematologic malignant tumors. Despite its clinical efficacy, many patients with cancer experience nonresponse to CAR T-cell treatment, disease relapse within months, or severe adverse events. Furthermore, CAR T-cell therapy has demonstrated minimal to no clinical efficacy in the treatment of solid tumors in clinical trials.

Observations

A complex interplay between high tumor burden and the systemic and local tumor microenvironment on clinical outcomes of CAR T-cell therapy is emerging from preclinical and clinical data. The hallmarks of advanced cancers—namely, inflammation and immune dysregulation—sustain cancer progression. They negatively affect the production, expansion, antitumor activity, and persistence of CAR T-cell products. Understanding of CAR T-cell therapy, mechanisms underlying its failure, and adverse events under conditions of high tumor burden is critical for realizing the full potential of this novel treatment approach.

Conclusions and Relevance

This review focuses on linking the efficacy and safety of CAR T-cell therapy with tumor burden. Its limitations relative to high tumor burden, systemic inflammation, and immune dysregulation are discussed. Emerging clinical approaches to overcome these obstacles and more effectively incorporate this therapeutic strategy into the treatment paradigm of patients with solid malignant tumors are also described.
Large Language Model Advanced Data Analysis Abuse to Create a Fake Data Set in Medical Research
Authors: Taloni Andrea , Scorcia Vincenzo , Giannaccare Giuseppe
Published: November 2023

This quality improvement study evaluates the ability of GPT-4 Advanced Data Analysis to create a fake data set that can be used for the purpose of scientific research.
Sensing Mucus Physiological Property In Situ by Wireless Millimeter‐Scale Soft Robots
Authors: Xiao Boyang , Xu Yilan , Edwards Steven , Balakumar Lohit , Dong Xiaoguang
Published: November 2023

The physiological property of mucus is an important biomarker for monitoring the human health conditions and helping understand disease development, as mucus property such as viscosity is highly correlated with inflammation and other diseases. However, it remains challenging to sense mucus viscosity using pure medical imaging. Collecting and analyzing mucus sample in vitro using flexible endoscopes and capsule endoscope robots is also challenging due to their difficulty of accessing very confined, tortuous, and small spaces, and the sample may not reflect the real mucus property. Here a novel method is proposed to enable sensing mucus viscosity in situ by wireless miniature sensors actuated by magnetic fields and tracked by medical imaging. These miniature viscosity sensors can be delivered with minimal invasion using a novel sensor delivery mechanism by controlling a magnetically actuated millimeter‐scale soft climbing robot. As the soft robot can access confined and narrow spaces, and reliably deploy the sensor on soft tissue surfaces, multiple sensors can be delivered on soft biological tissues to sense biofluid viscosity spatiotemporally. The proposed minimally invasive robotic delivery and viscosity sensing method thus paves the way toward sensing biofluid properties deep inside the body for future disease monitoring and early diagnosis functions.
Multiresponsive MXene Actuators with Asymmetric Quantum‐Confined Superfluidic Structures
Authors: Ma Jia‐Nan , Ma Bo , Wang Zheng‐Xiao , Song Pu , Han Dong‐Dong , Zhang Yong‐Lai
Published: November 2023

MXene, which is known for its high electrical/thermal conductivity, surface hydrophilicity, excellent mechanical flexibility, and chemical stability, is a versatile and smart material for soft actuators. However, most MXene actuators are fabricated by combining MXene with other inert materials to form a bilayer or multilayer structure. Considering the strain mismatch at multimaterial interfaces under frequent deformation, MXene‐based actuators are generally associated with poor stability, which limits their practical applications. Herein, inspired by the natural quantum‐confined superfluidic (QSF) effect, a multiresponsive MXene actuator that can be driven by moisture, light, and electricity by engineering an asymmetric QSF structure on both sides of the MXene film is reported. The actuation mechanism of the MXene film can be attributed to nonuniform water adsorption, transport, and desorption within the asymmetric QSF channels under moisture, photothermal, and electrothermal stimuli. Interestingly, MXene actuators can be flexibly formed into various shapes under moisture‐assisted mechanical compression, which not only enhances their multiresponsive actuation, but also permits a more complex deformation. As proof‐of‐concept demonstrations, various intriguing applications including a dual‐role robot, a smart shielding curtain, and a dragonfly robot, are fabricated, revealing the potential of MXene actuators for soft robotics.
Accommodative Organoammonium Cations in A‐Sites of Sb─In Halide Perovskite Derivatives for Tailoring BroadBand Photoluminescence with X‐Ray Scintillation and White‐Light Emission
Authors: Huang Hanlin , Yang Yalin , Qiao Shuoyan , Wu Xiaodong , Chen Zheyan , Chao Yu , Yang Kaidong , Guo Weiping , Luo Zhongzhen , Song Xiaorong , Chen Qiushui , Yang Chengkai , Yu Yan , Zou Zhigang
Published: November 2023

Broadband emissive perovskites are next‐generation materials for solid‐state lighting and radiative detection. However, white‐emitting perovskites are generally synthesized by regulating B/X sites, while not enough attention is paid to the A‐site, which is thought to hardly affect the band‐edge structures and optoelectronic properties. Here, a series of Sb3+‐doped In‐based 0D halide perovskite derivatives are described with various organoammonium cations in A‐sites. Warm‐white light emitting across the visible spectrum (450–850 nm), large Stokes shifts, and high photoluminescence quantum yields are easily tunable by molecularly tailoring A‐site cations. These features enable a light yield up to 60976 Photons/MeV as X‐ray scintillator, and a detection limit of 90 nGyair/s that is ≈60 times lower than the medical requirement. It is proved that A‐site plays a critical role in determining the degree of distortion of polyhedra, which influences the broadband photoluminescence and self‐trapped exciton (STE) dominates the emission process. Moreover, for the first time, via the incorporation of 2,6‐dimethylpiperazine, a mixed A‐site regulating strategy produces a standard white‐light emission, which originates from the blue‐light and yellow‐light related to various STE emission centers. It is foreseen that this strategy highlights the expanded role of A‐site and the importance of rethinking A‐sites in perovskites.
Modulating Cardiac Hemodynamics Using Tunable Soft Robotic Sleeves in a Porcine Model of HFpEF Physiology for Device Testing Applications
Authors: Rosalia Luca , Ozturk Caglar , Wang Sophie X. , Quevedo‐Moreno Diego , Saeed Mossab Y. , Mauskapf Adam , Roche Ellen T.
Published: November 2023

Heart failure with preserved ejection fraction (HFpEF) is a major challenge in cardiovascular medicine, accounting for ≈50% of all cases of heart failure. Despite the ongoing efforts, no medical device has yet received FDA approval. This is largely due to the lack of an in vivo model of the HFpEF hemodynamics, resulting in the inability to evaluate device effectiveness in vivo prior to clinical trials. Here, the development of a highly tunable porcine model of HFpEF hemodynamics is described using implantable soft robotic sleeves, where controlled actuation of a left ventricular and an aortic sleeve can recapitulate changes in ventricular compliance and afterload associated with a broad spectrum of HFpEF hemodynamic phenotypes. The feasibility of the proposed model in preclinical testing is demonstrated by evaluating the hemodynamic response of the model post‐implantation of an interatrial shunt device, which is found to be consistent with findings from in silico studies and clinical trials. This work overcomes limitations of prior HFpEF models, such as low hemodynamic accuracy, high costs, and long development phases. The versatile and adjustable platform introduced can transform HFpEF device development, aiming to enhance the lives of the 32 million people affected globally.
Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction
Authors: Fang Chunyan , You Yaodong , Luo Fan , Li Zheng , Shen Yifeng , Wang Fangyue , Zhang Jingyi , Gan Ren‐You , Ye Yulong
Published: November 2023

Bisphenol A (BPA) is a prevalent endocrine disruptor found in natural environments. Exposure to BPA has been associated with male infertility. The natural phytochemical icariin (ICA) has demonstrated significant promise for the treatment of male infertility. However, its effectiveness is limited due to its low bioavailability, poor water solubility, and insufficient targeting abilities. Herein, novel nanoparticles are generated from the natural silk fibroin, which are used to load ICA. The efficient drug delivery system (ICA‐SNPs) result in significantly focused drug distribution to spermatogonium, enhancing the anti‐infertility properties of ICA, and can effectively mitigate spermatogenesis dysfunction induced by BPA, control serum sex hormone levels, and enhance testicular ultrastructure. Additionally, the ICA‐SNPs restore spermatogenesis dysfunction primarily via the hormone biosynthesis, spermatogonium meiosis process, and glycerophospholipid metabolism.
Harnessing Human Placental Membrane‐Derived Bioinks: Characterization and Applications in Bioprinting and Vasculogenesis
Authors: Comperat Léo , Chagot Lise , Massot Sarah , Stachowicz Marie‐Laure , Dusserre Nathalie , Médina Chantal , Desigaux Théo , Dupuy Jean‐William , Fricain Jean‐Christophe , Oliveira Hugo
Published: November 2023

Bioprinting applications in the clinical field generate great interest, but developing suitable biomaterial inks for medical settings is a challenge. Placental tissues offer a promising solution due to their abundance, stability, and status as medical waste. They contain basement membrane components, have a clinical history, and support angiogenesis. This study formulates bioinks from two placental tissues, amnion (AM) and chorion (CHO), and compares their unique extracellular matrix (ECM) and growth factor compositions. Rheological properties of the bioinks are evaluated for bioprinting and maturation of human endothelial cells. Both AM and Cho‐derived bioinks sustained human endothelial cell viability, proliferation, and maturation, promoting optimal vasculogenesis. These bioinks derived from human sources have significant potential for tissue engineering applications, particularly in supporting vasculogenesis. This research contributes to the advancement of tissue engineering and regenerative medicine, bringing everyone closer to clinically viable bioprinting solutions using placental tissues as valuable biomaterials.
Dislodgement of Hydrogen Bubbles in Microchannels with Embedded Pillars: An Analytical, Experimental, and Numerical Study
Authors: Gräfner Simon Johannes , Huang Jeng‐Hau , Wu Po‐Yi , Renganathan Vengudusamy , Shih Po‐Shao , Kao Chengheng Robert
Published: November 2023

Microchannels with integrated pillars have enhanced the production capabilities and performance of various applications due to their high surface‐to‐volume ratio. However, emerging gas bubbles can become trapped, potentially limiting the functionality or efficiency of the device when scaled down to the low‐micrometer scale. Understanding the conditions required to dislodge these bubbles is thus critical for optimizing microfluidic devices with complex physical behaviors. Here an analytical model is presented that outlines the dislodgment conditions and driving forces for such gas–liquid flows. These terms are derived from the gas–liquid interface properties, geometry, and processing parameters. As the density of the pillar arrangement is scaled down, the resistance to bubble dislodgment typically increases. Nevertheless, the bubble is compelled to dislodge at lower pressure loads when critical volumes are reached. This newly discovered effect is particularly noticeable in densely packed arrays and can be explained by the interplay of increased surface tension, geometrical restrictions, and volume‐preserving forces. The analytical terms and effects are validated through novel experimental and numerical methods tailored for microchannels in the low‐micrometer scale, showing strong agreement.
Atomic‐Scale Defected HfS2 Nanosheets: A Novel Platform Enhancing Photocatalysis
Authors: Talebian‐Kiakalaieh Amin , Hashem Elhussein M. , Guo Meijun , Xia Bingquan , Ran Jingrun , Qiao Shi‐Zhang
Published: November 2023

Recently, novel 2D materials with fascinating characteristics are extensively applied to design/fabricate high‐activity and cost‐effective photocatalysts for solar‐driven fuels/chemicals generation. Among these 2D materials, HfS2 nanosheets (NSs) exhibit excellent features of large surface area, short bulk‐to‐surface distance, alterable band structures, and vast catalytic sites. Despite these features, no realistic experimental works on HfS2‐based materials are reported in photocatalysis field. Moreover, it is interesting but challenging to realize atomic‐scale engineering of compositions/structures for novel 2D materials and to relate these atomic‐scale characteristics with the element/space/time‐resolved charge kinetics of 2D materials‐based photocatalysts. Herein, for the first time, atomic‐scale defected HfS2 NSs are designed/synthesized. The as‐synthesized HfS2 NSs are combined with various photocatalysts to acquire novel HfS2‐TiO2, HfS2‐CdS, HfS2‐ZnIn2S4, and HfS2‐C3N4 composites, respectively. Among them, HfS2‐CdS exhibits the highest rate (5971 µmol g−1 h−1) on hydrogen (H2) evolution in triethanolamine aqueous solution, together with obviously‐enhanced rates on H2 (2419 µmol g−1 h−1) and benzaldehyde (5.11 mmol g−1 h−1) evolution in benzyl alcohol aqueous solution. Various state‐of‐art characterizations reveal the element/space/time‐resolved electron/hole kinetics in HfS2‐CdS composites, disclosing that these atomic‐scale S vacancies temporarily trapping electrons to facilitate spatiotemporal electron–hole separation/transfer. This work paves avenues to atomic‐scale design/synthesis of new 2D‐materials‐based photocatalysts for sunlight utilization.
Controllable Oxygen‐Incorporated 2D‐SnSe2 Layered Thin Film by Plasma‐Assisted Selenization Process with Enhanced NO2 Gas Sensitivity and Improved Humidity Stability
Authors: Wang Kuangye , Kuo Tzu‐Wen , Yang Tzu‐Yi , Cyu Ruei‐Hong , Hsu Chen‐Wei , Hsu Yu‐Chieh , Yu Yi‐Jen , Chen Yu‐Ze , Chueh Yu‐Lun
Published: November 2023

Herein, oxygen‐incorporated 2D‐SnSe2 layered films are successfully fabricated by a plasma‐assisted selenization process. The oxygen concentrations inside the 2D‐SnSe2 layered film are controllable by controlling the proportion of hydrogen in the mixed gas of nitrogen and hydrogen during the plasma‐assisted selenization reaction. Oxygen atoms mainly exist in the form of the incorporated oxygen in the 2D‐SnSe2 layered film with an exceedingly small grain size of SnO2, which significantly increases the total interface area of the SnO2/SnSe2. Significant enhancement of the gas response to NO2 (709% under 100 ppb NO2) is reached when the proportion of hydrogen during the plasma‐assisted selenization process is 25%, thus showing excellent sensitivity and selectivity. Moreover, the sensor also demonstrated excellent stability under an increase in relative humidity. It is verified that the response will not significantly decrease when the relative humidity is below 90%. The obtained results demonstrate that oxygen‐incorporated 2D‐SnSe2 layered film with excellent commercial potential, is a highly suitable candidate for next‐generation gas sensors.
Synthesis of Furan and Benzene Fused 2‐Tetralones via Photo‐Induced Rearrangement of 2′‐(Furan‐2‐yl)‐[1,1′‐Biphenyl]‐4‐ols
Authors: Niu Lixin , Fan Jinming , Liu Bo , Wang Ding , Wang Tao , Zhang Zunting
Published: November 2023

A concise method for the synthesis furan and benzene fused 2‐tetralones via photo‐induced rearrangement of 2′‐(furan‐2‐yl)‐[1,1′‐biphenyl]‐4‐ols was developed. Under argon atmosphere and room temperature, 6,7‐dihydrophenanthro[9,10‐b]furan‐5(4H)‐ones were obtained by irradiating 2′‐(furan‐2‐yl)‐[1,1′‐biphenyl]‐4‐ols with a 254 nm UV lamp (64 W) in dichloromethane (DCM) for 1 hour. The reaction mechanism includes 6π‐electrocyclization, thermal suprafacial [1,5]‐H shift, double thermal suprafacial [1,3]‐H shift and keto‐enol isomerization.
One‐Pot Access to 3‐Sulfonyl Flavones via K2CO3‐Mediated Annulation of α‐Sulfonyl o‐Hydroxyacetophenones with Substituted Nitriles
Authors: Chang Meng‐Yang , Lin Chun‐Yi
Published: November 2023

The one‐pot construction of diversified sulfonyl flavones was developed by K2CO3‐mediated formal (5+1) stepwise annulation of α‐sulfonyl o‐hydroxyacetophenones with substituted nitriles under the open‐flask atmosphere conditions. A plausible mechanism is proposed and discussed. This method provides intermolecular and intramolecular ring‐closure via the formations of one carbon‐oxygen single (C−O) bond, one carbon‐carbon (C=C) double bond, and the cleavage of one carbon‐nitrile triple (C≡N) bond.
Divergent Synthesis of Anisidines by Controlling Cu‐Catalyzed [1,3]‐Methoxy Rearrangement
Authors: Nakamura Itaru , Konta Riku , Ishida Yasuhiro , Tachibana Mai , Terada Masahiro
Published: November 2023

A divergent synthesis of ortho‐anisidines was achieved by controlling Cu‐catalyzed [1,3]‐methoxy rearrangement. The reactions of N‐alkoxyanilines having an electron‐donating group (EDG), such as an alkyl or anisyl group, at the ortho position and a pivaloyl group on the nitrogen atom in the presence of catalytic amounts of IPrMeCuCl and AgNTf2 afforded the corresponding 6‐substituted 2‐anisidines with good product selectivity through a [1,3]‐rearrangement of the methoxy group to the unsubstituted ortho position. In contrast, the reactions of N‐ methoxyanilines having a benzyloxycarbonyl group on the nitrogen atom using IPrCuBr and AgBF4 as catalysts afforded 3‐substituted 2‐anisidines via a domino process involving a [1,3]‐rearrangement of the methoxy group to the EDG‐substituted ortho position followed by a [1,2]‐rearrangement of the EDG of the resulting ortho‐quinol imine intermediate.
Pressure‐Induced Superconductivity and Topological Quantum Phase Transitions in the Topological Semimetal ZrTe2
Authors: Zhu Shihao , Wu Juefei , Zhu Peng , Pei Cuiying , Wang Qi , Jia Donghan , Wang Xinyu , Zhao Yi , Gao Lingling , Li Changhua , Cao Weizheng , Zhang Mingxin , Zhang Lili , Li Mingtao , Gou Huiyang , Yang Wenge , Sun Jian , Chen Yulin , Wang Zhiwei , Yao Yugui , Qi Yanpeng
Published: November 2023

Topological transition metal dichalcogenides (TMDCs) have attracted much attention due to their potential applications in spintronics and quantum computations. In this work, the structural and electronic properties of topological TMDCs candidate ZrTe2 are systematically investigated under high pressure. A pressure‐induced Lifshitz transition is evidenced by the change of charge carrier type as well as the Fermi surface. Superconductivity is observed at around 8.3 GPa without structural phase transition. A typical dome‐shape phase diagram is obtained with the maximum Tc of 5.6 K for ZrTe2. Furthermore, the theoretical calculations suggest the presence of multiple pressure‐induced topological quantum phase transitions, which coexists with emergence of superconductivity. The results demonstrate that ZrTe2 with nontrivial topology of electronic states displays new ground states upon compression.
Auxetic Photonic Patterns with Ultrasensitive Mechanochromism
Authors: Lee Hwan‐Young , Gu Minbon , Hwang Jeonghee , Hwang Hyerim , Kim Young‐Seok , Lee Su Yeon , Kim Shin‐Hyun
Published: November 2023

Photonic crystals with mechanochromic properties are currently under intensive study to provide intuitive colorimetric detection of strains for various applications. However, the sensitivity of color change to strain is intrinsically limited, as the degree of deformation determines the wavelength shift. To overcome this limitation, auxetic photonic patterns that exhibit ultra‐sensitive mechanochromism are designed. These patterns have a regular arrangement of cuts that expand to accommodate the strain, while the skeletal framework undergoes torsional deformation. Elastic photonic crystals composed of a non‐close‐packed array of colloidal particles are embedded in the cut area of the auxetic patterns. As the cut area amplifies the strains, the elastic photonic crystals show significant color change even for small total strains. The degree of local‐strain amplification, or sensitivity of color change, is controllable by adjusting the width of cuts in the auxetic framework. In this work, a maximum sensitivity of up to 60 nm/% is achieved, which is 20 times higher than bulk films. It is believed that the auxetic photonic patterns with ultra‐sensitive mechanochromism will provide new opportunities for the pragmatic use of mechanochromic materials in various fields, including structural health monitoring.
Potential Application of Organic Electronics in Electrical Sensing of Insects and Integrated Pest Management towards Developing Ecofriendly Replacements for Chemical Insecticides
Authors: Petrauskas Lautaro N. , Haase Katherina , Schmidt Georg C. , Hübler Arved C. , Mannsfeld Stefan C. B. , Ellinger Frank , Boroujeni Bahman K.
Published: November 2023

Synthetic insecticides are widely used against plant pest insects to protect the crops. However, many insecticides have poor selectivity and are toxic also to beneficial insects, animals, and humans. In addition, insecticide residues can remain on fruits for many days, jeopardizing food safety. For these reasons, a reusable, low‐cost electronic trap that can attract, detect, and identify, but attack only the pest while leaving beneficial insects unharmed could provide a sustainable, nature‐friendly replacement. Here, for the first time, research results are presented suggesting the great potential and compatibility of organic electronic devices and technologies with pest management. Electrical characterizations confirm that an insect's body has relatively high dielectric permittivity. Adaptive memcapacitor circuits can track the impedance change for insect detection. Other experiments show that printed polymer piezoelectric transducers on a plastic substrate can collect information about the weight and activity of insects for identification. The breakdown voltage of most insects´ integument is measured to be <200 V. Long channel organic transistors easily work at such high voltages while being safe to touch for humans thanks to their inherent low current. This feasibility study paves the way for the future development of organic electronics for physical pest control and biodiversity protection.
Supramolecular photoresponsive polyurethane with movable crosslinks based on photoisomerization of azobenzene
Authors: Zhou Xin , Ikura Ryohei , Jin Changming , Yamaoka Kenji , Park Junsu , Takashima Yoshinori
Published: November 2023

Light‐driven actuators are widely used for smart devices such as soft robots. One of the main challenges for actuators is achieving rapid responsiveness, in addition to ensuring favorable mechanical properties. Herein, we focused on photoresponsive polyurethane (CD‐Azo‐PU) based on controlling the crystallization of the hard segments in polyurethane (PU) by complexation between azobenzene (Azo) and cyclodextrins (CDs). CD‐Azo‐PU incorporated polyurethane as the main chain and a 1:2 inclusion complex between Azo and γCD as a movable crosslink point. Upon ultraviolet light (UV, λ = 365 nm) irradiation, the photoresponsiveness of CD‐Azo‐PU bent toward the light source (defined as positive), while that of the linear Azo polyurethane (Azo‐LPU) without peracetylated γ‐cyclodextrin diol (TAcγCD‐diOH) as a movable crosslinker bent in the direction opposite the light source. The bending rates were determined to be 0.25°/s for CD‐Azo‐PU and 0.083°/s for Azo‐LPU, indicating that the bending rate for CD‐Azo‐PU was faster than that for Azo‐LPU. By incorporating movable crosslinks into CD‐Azo‐PU, we successfully achieved specific photoresponsive actuation with an enhanced rate.
Pressure‐induced emission (PIE) in halide perovskites toward promising applications in scintillators and solid‐state lighting
Authors: Zhao Wenya , Xiao Guanjun , Zou Bo
Published: November 2023

High‐pressure chemistry has provided a huge boost to the development of scientific community. Pressure‐induced emission (PIE) in halide perovskites is gradually showing its unique charm in both pressure sensing and optoelectronic device applications. Moreover, the PIE retention of halide perovskites under ambient conditions is of great commercial value. Herein, we mainly focus on the potential applications of PIE and PIE retention in metal halide perovskites for scintillators and solid‐state lighting. Based on the performance requirements of scintillator and single‐component white light‐emitting diodes (WLEDs), the significance of PIE and PIE retention is critically clarified, aiming to design and synthesize materials used for high‐performance optoelectronic devices. This perspective not only demonstrates promising applications of PIE in the fields of scintillators and WLEDs, but also provides potential applications in display imaging and anti‐counterfeiting of PIE materials. Furthermore, solving the scientific disputes that exist under ambient conditions is also simply discussed as an outlook by introducing high‐pressure dimension to produce PIE.
Layer‐by‐layer adhesion of hydrogels for constructing heterogeneous microfluidic chips
Authors: Shen Chong , Li Yingjun , She Wenqi , Meng Qin
Published: November 2023

Hydrogel‐based microfluidics have emerged as a promising platform for constructing organs‐on‐chips, offering in vivo‐relevant micro‐environments. However, the fabrication of complex microchannels using hydrogels remains challenging and often fails to replicate the intricate organ structures. Here, we introduce a novel methodology called “layer‐by‐layer adhesion” for the construction of complex microfluidic chips. Leveraging a hydrosoluble and photo‐crosslinkable adhesive, chitosan methacryloyl (CS‐MA), we successfully stitched various hydrogels together in a layer‐by‐layer fashion to form perfusable microchannels. Our results demonstrate the versatility of CS‐MA in bonding different hydrogels, with adhesion energies ranging from 1.2 to 140 N m−1. By implementing the layer‐by‐layer adhesion approach, heterogeneous hydrogel‐based microchannels were fabricated with diverse morphologies. We applied this technique to establish liver‐on‐a‐chip by entrapping hepatic cells within a biocompatible gelatin methacryloyl layer and overlaying it with perfusable microchannels in a robust F127‐DA layer. The “layer‐by‐layer adhesion” technique offers a facile, efficient, and cytocompatible approach for engineering user‐defined hydrogel‐based chips.