bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Ethanolic leaf extract of Elaeocarpus tectorius (Lour.) Poir. on Retinal Oxidative Stress in Streptozotocin-nicotinamide Induced Diabetic rats
Authors: Manoharan Keerthana , Chitra P
Published: June 2023

Oxidative stress plays a crucial role in the pathogenesis of diabetic retinopathy and causes loss of vision. Elaeocarpus tectorius (Lour.) Poir. is a tree species that bears edible fruits and is traditionally used to treat diabetes. The study is aimed to investigate the ameliorative effect of ethanolic leaf extract of E. tectorius on retinal oxidative stress and aldose reductase levels in STZ-NIC-induced diabetic rats. The leaf extract was orally administered to diabetic rats once a day for about 28 days at doses of 200 and 400 mg/kg b.w. Fasting blood glucose levels were determined at regular intervals during the treatment period and retinal superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, lipid peroxidation levels and aldose reductase activity were assessed at the end of the experiment. Oral administration of E. tectorius leaf extract caused a significant decrease in the fasting blood glucose levels of diabetic rats. The extract also improved the retinal antioxidant status by increasing the levels of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione. The rate of lipid peroxidation was lowered in diabetic rats as a result of treatment with the leaf extract. The diabetic rats treated with the leaf extracts also had lower retinal aldose reductase activity when compared to the untreated diabetic rats. This study suggests that Elaeocarpus tectorius leaf extracts exhibit protective effects and improve the antioxidant status of the retina under diabetic conditions helping in the prevention and management of diabetic retinopathy.
Physicochemical Evaluation and Standardization of Traditional Healing Herb Sonchus asper Linn
Authors: Salokhe Shivani , G. Killedar Suresh , A. Tamboli Firoj , N. More Harinath , V. Desai Vaibhava , R. Rasal Prasanna , M. Alaskar Kamal , Atkeere Uddhav , Kamble Sangmitra
Published: June 2023

Sonchus asper also locally known as prickly sow-thistle, rough milk thistle, spiny sowthistle, spiny-leaved sow thistleordudhi, is a widespread plant an annual or biennial herb sometimes reaching a height of 200 cm. with spiny leaves and yellow flowers resembling those of the dandelion. Traditionally it has been used in the treatment of numerous disorders and many resembling plants of the genus Sonchas create confusion hence its standardization is necessary. In the present work we have tried to standardize the entire herb based on physical, chemical, microscopical, and Physico-chemical investigations to provide the proximate values for its proper identification. The present work will help the traditional healers for selecting the correct herb for treating different disorders and avoid the wrong choice of crude drugs which may lead to unsatisfactory results for intended use or it may cause discomfort for many patients. Further work is going on for the biological evaluation of this herb to provide scientific validation of its traditional claims.
Effect of Omega 7 on Some Parameters Related to WBCs and RBCs in Methotrexate-induce Blood Toxicity in Mice
Authors: Hilal Hassani Zahraa , Faris Hassan Ali
Published: June 2023

Background: Although methotrexate (MTX) is a frequently used chemotherapy drug, its effectiveness is sometimes hampered by the drug's toxic consequences. Omega 7 is a monounsaturated fatty acid, with different anti-inflammatory, anti-diabetic anti-obesity applications, and its possible protective effects against MTX-induced blood toxicity were investigated in this study. Objective: Evaluation of possible protective effects of omega7 against MTX-induced blood toxicity. Methods: 30 mice were divided into five groups, the First group take liquid paraffin orallyfor 7 days for served as negative control and the second group take methotrexate (20mg/kg) intraperitoneallyto serve as a positive control,the third group takes omega 7 (100mg/kg)orally for 7 days, forth groupreceived (50mg/kg ) omega 7orally for 7 days as well as give It methotrexate (20mg/kg) on day 8, the fifth groupreceived (100mg/kg ) omega 7orally for 7 days as well as give It methotrexate (20mg/kg) on day 8. After that, the animals were killed and took blood samples for measuring blood parameters, such as PCV, Hb, MCV, MCH, platelet, WBC count and Differential WBC. Results: the results showed the presence of a decrease in both the RBC from which MCV and MCH count showed a significant decrease at a dose of 20mg/kg concentration of methotrexate, omega7 at a dose of 50 and 100 mg/kg work to increase the variables above, Concerning the WBC was significantlydecreased in the totals and increased in monocytes count for the study when giving methotrexate while reversed when giving omega7 with this drug. Conclusion: omega7 has a significant protective role in Methotrexate-induce Blood Toxicity in Mice.
Physicochemical, Phytochemical Evaluation and Pharmacological Investigation of Roystonea regia
Authors: Muhammad Usama Munir , Muhammad Asad Saeed , Zeeshan Masood , Aslam Nazia , Farooq M.
Published: June 2023

Natural products are always been the great source of therapeutic agents. The aim of the study was to analyze the physicochemical properties of Roystonea regia plant which were performed on its powder. All the results were in their official limits. Extraction was done with n-hexane, chloroform and ethanol using Soxhlet apparatus and phytochemicals of different extracts of plant were evaluated with freshly prepared reagents. Anti-oxidant activity of plant by Total Phenolic Content (TPC) method revealed that all extracts specially ethanol extract has anti-oxidant potential of 398.6 mg/g of GAE. In anti-pyretic activity Swiss albino rats containing weight 150 to 200 mg were used and results showed the dose dependent effects of all extracts from 1st hour to 5th hour after the administration of yeast. Results were analyzed by using ANOVA along with Dunnett’s test.
Prevalence of Non-Communicable Disease in HIV Infected patients coming to Emergency Medicine and Critical Care Department in A Tertiary Care Centre in South India
Authors: Venugopalan Ajith , Karunanithi Krupanidhi , TP Sreekrishnan , Thampi Anooja , Joy Jinu , Thomas Thara , Ashok B Aswathy , PR Roshini , Koshy Vimal , Sreekumar G. , Kumar KP Gireesh
Published: June 2023

Introduction: AIDS (acquired immune deficiency syndrome), caused by the human immune deficiency virus (HIV), is a chronic, potentially life-threatening condition. Non-communicable diseases require long – term care and treatment as they are chronic conditions that result in lifelong health consequences. In our study we tried to evaluate the prevalence of Non-Communicable Diseases (NCD) among HIV patients. Methodology: This is a prospective study consisting 191 patients who were presented to the Emergency Medicine and Critical Care Department over 2 year for various HIV related acute problems. Chi-square test was used to find significance of association of qualitative variables. Atherosclerotic cardiovascular disease scale (ASCVD) and Framingham risk score were used. Results: 65.45% of patients were in the age group 40-60 yrs. From the total number of HIV patients, 64.92% (123) of patients were affected by NCDs. The prevalence rate of dyslipidemia 49(25.7%) was found to be high, followed by hypertension 48(25.1%) and diabetes 36(18.8%). There is a major association (p value < 0.001) linking Framingham score and CAD and a borderline significance (p=0.093) between ASCVD score and CAD. Conclusion: The prevalence rate of non-communicable diseases among retro positive patients is high and should be screened in the same manner as done for routine patients. HIV patients presents to the Emergency room with disease related deteriorations and also with NCD associated complications. When managing in the emergency room it is always essential to think of these NCDs in HIV patients and the complication it can produce. This will help in early diagnosis, evaluate the complication in more organised manner and provide effective management. This will also provide in reducing the morbidity and mortality among such patients.
A Comparative Study of the fast and slow Progression of Diabetes and Network Analysis by Graphical measures
Authors: Krishnan Athira , R Manjusha
Published: June 2023

Graphical measures such as closeness, average length, the eccentricity of a vertex estimates how fast the flow of information would be through a given node to other. In this paper, we analysing networks and aim is to find the most important nodes in a network. Thereby in a social network we can evaluate whether combinations of symptoms or addition of other symptoms can better classifypersons for assessing any criteria.Also, we study the betweenness centrality of a vertex that measures the collision domain in a network.
The Role of Porphyromonas gingivalis in Oral Biofilm: Pathophysiology in Chronic Periodontitis
Authors: Soesilawati Pratiwi , Imamatul Ummah Nur , Mega Rahma Syahnia Sesaria Junita , Luthfiyya Arini Niken , Sjuhada Oki Aqsa
Published: June 2023

Periodontitis is a destructive inflammatory disease caused by a specific microorganism causing progressive damage to areas, especially the alveolar bone and periodontal ligament. Clinical manifestations of periodontitis are tooth mobility, pocket formation, and loss of attachment. Periodontitis is divided into two groups, namely aggressive and chronic periodontitis. The prevalence of chronic periodontitis in the world is around 50%. Meanwhile, the prevalence of chronic periodontitis in Indonesia, according to Riskesdas 2018 is 67.8%. Porphyromonas gingivalis is a bacterium that causes chronic periodontitis, which can form biofilm plaque and cause damage to periodontal tissue resulting in tooth loss. The formation of biofilm plaques due to accumulation of opportunistic bacterial species accompanied by increased gram-negative bacterial. These changes in composition affect the host's immune response so that periodontitis develops into a chronic inflammatory condition. Therefore, we conducted a literature search to analyze the effect of oral biofilms on chronic periodontitis.
Response of New Para Hydroxy Benzoic Acid Derivative and Coriandrum sativum leaves extract against periodontitis causing bacteria
Authors: Manogaran Yoghinni , Jagadeesan Dharshini , Narain Kamal , Kumari Usha , Anand Preetha , Shanmugavelu Shalini
Published: June 2023

Bacteria ability to predominate the periodontitis (PI), antimicrobial potential of Coriandrum sativum and para hydroxy benzoic acid intended present study to compare the antimicrobial potential of new para hydroxy benzoic acid derivative and hydroalcoholic extract of Coriandrum sativum leaves (HECSL) against periodontitis causing bacteria (PCB). Present study involved synthesis of a new para hydroxy benzoic acid derivative and preparation of HECSL. Synthesized compound was characterized using ATR-IR, 1H-NMR and Mass spectrometric data. Both new para hydroxy benzoic acid derivative (PHBAD) and HECSL were further tested for their antibacterial potential against PCB such as Escherichia coli and Staphylococcus aureus. Both PHBAD and HECSL exhibited high antibacterial potential against PCB, however PHBAD exhibited much higher antibacterial potential. Present study concludes that PHBAD possess high antibacterial potential against PCB and recommends that PHBAD should be further evaluated for its preclinical significance.
Controlled Drug Release from Hydrogel Formulations for The Localised Delivery of Anticancer Agents to Solid Tumors
Authors: Fouad Mohammed Dhelal , Mohamed A Elsawy , A. Faraj Jabar , M.Mohammed Shaimaa
Published: June 2023

The hydrogel of the β-sheet self-assembled peptides is one of the powerful vehicles for the drug delivery and other biomedical applications. This class of hydrogel contains both hydrophilic and hydrophobic moieties. Therefore, it plays an integral part in the delivering of the hydrophobic drugs, which considers as a main challenge to overcome when dealing with hydrogels, this is because hydrogels are hydrophilic in nature. Herein, Doxorubicin has been used as a model anticancer agent because it is the most widely known as an anthracycline antibiotic with high anticancer activity. The major challenge with this chemotherapeutic agent its poor aqueous solubility, thus attempts have been made to transform it into hydrogel via hydrophobic interactions. The release of doxorubicin from the hydrogels at the tumour cells, is the vital aim here. Controlling the Dox release has been achievable through monitoring several parameters, such as the gel concentrations, PH, time, and the number of lysine residues. The mechanical properties, secondary structure and the morphology of the peptide hydrogels and Dox hydrogels were also assessed, via using the Rheometer, FTIR and SEM.
Quantifying Pomalidomide in Human Plasma Employing UPLC-MS/MS
Authors: Alekhya K. , Nataraj K. S. , Pawar A. K. M. , Vaheeda Vaheeda
Published: June 2023

The current work aims to create a simple, fast, clear and accurate chromatography-tandem mass spectrophotometric (UPLC-MS/MS). 50µl ISTD (250ng/ml concentration) and 250µl of 5mM ammonium formate buffer (pH - 2.5) were put into the samples just before liquid-liquid extraction (LLE) using 2.5ml of tertiary butyl methyl ether (TBME). Chromatographic fraction was done using Hypersil gold column (50 mmX4.65mm, 5µ) with use of 5mM ammonium formate buffer (pH - 2.5) and acetone in 20: 80 v/v (mobile phase). The rate of flow was around 0.50ml/min. Pomalidomide and Celecoxib were ionized into ions with polarity (positive) and were recognized using MRM. Quantitation was made by transitions m/z 274.43 precursor ion to m/z 201.15 for drug Pomalidomide and m/z 382.12 precursor ion to m/z 362.0 of celecoxib. The concentrations of eight standards exhibited linearity between 1.9900 to 199.8380ng/ml (r2 ≥ 0.9968). Separation of chromatogram was obtained in two minutes. The recovery values in an average for three QC’s was 51.49% of Pomalidomide which was in concordance with acceptance. The Coefficient of variation was ≤15% in intra and inter batch assay values. The %CV ruggedness ranges from 1.26 - 2.25. Short and long term stability percentages of stock solutions were found acceptable like 99.76 and 98.69. Results show that all the validation parameters were in acceptable limits.
A UV Spectrophotometric Assay of Extended-Release Brands of Etodolac
Authors: Gayatri S. Naga , Vunguturi Shanthi , Kumar Angajala Kishore , sunitha Vianala , Shankaraiah S.
Published: June 2023

A simple, novel, economical and less time taking UV Spectrophotometric analysis was developed for Etodolac. The assay is relied on measuring optical density at lambda maximum 224.80nm wavelength using methanol as solvent. Four different brands of etodolac i.e. Etofree-ER (A), Toldin-ER (B), Etova-ER (C) and) Musran- ER (D) were procured from local market for analysis. The Drug sample was dissolved in methanol to get a concentration of 5μg/ml and its absorbance was measured. Similarly the samples of different brands were prepared in methanol with concentration range of 1-5μg/ml and their absorbance was recorded at 224.80nm following blank. The Assay percentage is being calculated and regression analysis is performed. The brand Etofree-ER (A) and Musran- ER (D) showed nearly same % Assay values i.e. 108.01% and 108.13% respectively. The brands Toldin-ER (B) and Etova-ER showed 105.42% and 106.84% Assay values. All the brands % Assay values were found to be with in limit as per Indian Pharmacopeia and their squared correlation co-efficient was also found to be 0.999 well within the limit.
Frankfort Horizontal Deviation Comparison in Natural Head Position on Discrepancy of Skeletal Pattern (Cephalometry Study)
Authors: Eka Wardani Dini , Hamid Thalca , Narmada Ida Bagus , Suharwan Mustaqbal
Published: June 2023

Cephalometry remain imperative in diagnosis and treatment planning. Commonly used craniofacial reference plane such as Frankfort Horizontal (FH), have shortcomings, including their variation individual orientation when Natural Head Position (NHP), so FH cannot be considered a true horizontal. The purpose of this study was to determine deviant FH, to highlight effect of deviant FH on the determination cephalometric values in vertical skeletal discrepancy cases dan to construct a true horizontal line (HOR) as alternate reference plane. Lateral cephalometric roentgenograms from 104 randomly selected patients, then determined FH inclination. Control group was created from FH inclination come near to true horizontal and study group was created from FH inclination away from true horizontal. Independent t test was done for both the groups to compare the values obtained and determine the statistic difference. Statistical analysis in control group shows that there is no significant difference between FH and HOR, which prove that HOR could be used as an alternative to FH. The study group showed a significant statistic difference, resulting in erroneous analysis if the deviant DH was used.
Design and Evaluation of Fast Dissolving Tablets a Novel Natural Superdisintegrant is used in the Development of a BCS Class -II Drug
Authors: Sekhar Naik D. Chandra , Bharathi A.
Published: June 2023

The main objective of the present investigation was to develop fast dissolving tablets for aceclofenac employing Ocimum gratissimum mucilage, a novel superdisintegrant by using 23factorial design. The mucilage was extracted from the seeds of Ocimum gratissimum and tested for flow properties. The senior development of fast dissolving tablets of Aceclofenac with novel natural mucilage as a superdisinitegrant in different ratios (0-5%) by using the direct compression method and Pre-compression and post-compression characteristics like water absorption (percent) and percent of drug dissolved at 5 min were evaluated for all of the formulated fast dissolving tablets. In all acceptable solvents and buffers, the mucilage powder was found to be a fine, free-flowing amorphous powder with good swelling properties. According to the FTIR and DSC investigations, there were no interactions between aceclofenac and the novel natural mucilage powder. In terms of drug content (98.0±0.14 to 99.9±0.05), hardness (3.8±0.03to 3.9±0.31), and friability (0.11±0.012 to 0.12±0.79), all of the formulation batches are of excellent quality. The batch with the improved formulation had a shorter disintegrant time (27±0.83). The improved formulation F2 has a shorter In–Vitro wetting time (19±0.69). The designed tablets' water absorption ratio was determined to be within the limit at (392.1±0.81). In 10 minutes, the cumulative drug dissolved in the optimised formulation F2 was determined to be (99.93%). As an outcome, it could be used in the formulation of fast dissolving tablets to provide an immediate release of the contained drug within 5 minutes.
Comparison of Serum Stability against Uric Acid and Glucose
Authors: Purwaningsih Nur Vita , Sari Maulidyanti Ellies Tunjung , Widyastuti Rahma
Published: June 2023

The selection of tools, especially the use of vacutainer tubes, affects the results of the examination to determine the stability of serum from plain vacutainer with vacutainer separation gel on the quality of uric acid and glucose test results. This study used an experimental design. The study took blood samples of 3 ml each in SST vacutainer and plain vacutainer serum. The mean uric acid levels using plain vacutainer and SST vacutainer were 4.5875±0.59048 and 4.9250±0.56318, respectively. The mean glucose levels using plain vacutainer and SST vacutainer were 90.64±12.33 and 94.12±13.30, respectively. Uric acid and glucose levels using gel-separated vacutainer were higher than uric acid levels using plain vacutainer. There was a significant difference in uric acid levels between regular vacutainers and SST vacutainers, similar to glucose levels (p = 0.000, p = 0.000). Uric acid and glucose levels using SST vacutainer were higher than uric acid levels using plain vacutainer. The following types of vacutainer separator gel and plain vacutainer affect the quality of uric acid and glucose test results.
Acute and Subacute Toxicity Studies of Ethanol, Chloroform extracts and Flower oil of Senecio edgeworthii hook plant
Authors: S. Shende Vikas , L. Kakadiya Jagdish
Published: June 2023

This study investigated the acute and subacute oral toxicity of SE- Oil, SE-Alcohol and SE-Chloro extracts of Senecio edgeworthii (SE) in a rodent for evaluating its safety profile. Senecio edgeworthii (SE) plant for the acute oral toxicity (300 to 5000mg/kg) and subacute oral toxicity SE- Oil (SE-Oil 50, 200, 500mg/kg) and SE-Chloro (SEC 100, 500, 1000mg/kg) and SE-Alcohol (SEA 100, 500, 1000mg/kg) studies were administered orally according to the guidelines 423 and 407 of OECD, respectively. In the acute oral toxicity study, doses are administered by 300mg/kg, 1000mg/kg, 2000mg/kg and 5000mg/kg (OECD guideline no. 423). SEA and SEC do not show toxicity up to 5000mg/kg; SE- Oil shows toxicity at a dose of 2500mg/kg. In the subacute toxicity study, the daily oral treatment with extracts of SEA and SEC 100, 500, 1000mg/kg, SE-Oil 50, 250, 500mg/kg of extracts for 28 days did not produce any death or hazard. Likewise, SEA and SEC 100, 500, 1000mg/kg, SE-Oil 50, 250mg/kg of Senecio edgeworthii hook no significant changes were recorded in food intake, body weight gain, the biochemical and haematological parameter of control and treated rats. SE-Oil 500mg/kg of significant changes were recorded in food intake and body weight gains are decreased compared to the control group and SE-Oil 500mg/kg there was a significant (P < 0.05) decrease in RBC counts in the treated animals compared to that of the control group counts in the treated animals and induction (ALT, AST, and alkaline phosphatase and Total protein). SE- Oil 500mg/kg of extract treaded group saw mild liver pathological findings characterized by abnormal hepatic configuration was observed with treated animals. The present result from the acute and subacute toxicity study Senecio edgeworthii hook alcohol and chloroform extract is considered relatively safe on acute and subacute oral exposure. Senecio edgeworthii hook flower hexane extract shows acute toxicity at dose 2500mg/kg and in subacute toxicity study, higher dose 500mg/kg.
The Synthesis AgNPs of Leaves Melastoma malabathricum Extract reduce Adult Haemonchus contortus Motility Assay
Authors: Suteky Tatik , Dwatmadji Dwatmadji
Published: June 2023

The research was performed to observe the effectiveness of silver nanoparticles (AgNPs) incorporate using the leaves Melastoma malabathricumin the ethanolic extract as anti-Haemonchus contortus. To determine the phytochemical content of Melastoma malabathricum, a qualitative phytochemical test was done. An adulticidal or an adult motility test was performed on mature female Haemonchus contortus. Three silver nanoparticle concentrations (AgNPs-Extract 0.2mgml-1, AgNPs-Extract 0.1mgml-1, AgNPs-Extract 0.05mgml-1) and two different ethanol extract Melastoma malabathricum concentrations (200mgml-1 and 100mgml-1) were examined. Albendazole 40mg/ml was used asa standard reference, and for negative control normal using saline water. The phytochemical analysis revealed that the ethanol extract of Melastoma malabathricum contains tannin, flavonoid, terpenoid, and steroid. The silver nanoparticles are identified visually as colour changes in the solution and using an ultraviolet-visible nanophotometer (UV-Vis). The spectrum was examined using a UV-Vis nanophotometer, and it revealed a clear peak around 365nm with a pH of 5.9. In a nematocidal assay on adult Haemonchus contortus, the paralysis time of the worm in silver nanoparticle (AgNPs- Extract 0.2mg/ml) was 8.85 minutes, which was significantly (P0.05) shorter than the control positive (14.07 minutes). Worms died in less than an hour in all treatments, and the negative control worm remained active for up to 2 hours after exposure
Antimicrobial, Antioxidant and Anti-inflammatory potential of flavonoid and terpenoid from Gymnosporia montana
Authors: Sutariya Sandip , Pansuriya Vidhi , Sharma Malika , Bajpai AB , Gupta Amit
Published: June 2023

Secondary metabolites (i.e. flavonoids and terpenoids) were reported in most of the medicinal plant products and showing several immunopharmacological properties which is totally related with human healthcare. In this regard, flavonoids and terpenoids contained in leaves and fruit extract were identified and characterized through high performance thin layer chromatography (HPTLC). Further, immunopharmacological studies were explored and investigate its antimicrobial, antioxidant and anti-inflammatory activity of flavonoids and terpenoids from the leaves and fruit extract of Gymnosporia montana. In this study, variable doses of flavonoids and terpenoids were taken into the consideration and studied various parameters. The results suggest that flavonoids and terpenoids at higher doses showed antimicrobial, antioxidant and anti-inflammatory activity as compared to control. Overall, secondary metabolites exceptionally flavonoids and terpenoids which are being scrutinized and explored its antimicrobial, antioxidant and anti-inflammatory activity leading to the outcome of new clinical drugs.
Development and in vitro assessment of Analgesic and Anti-inflammatory Mefenamic acid Nanosponge Loaded Topical Formulation
Authors: Chaurasia Himanshu , Chopra Himansu , Kumar Sagar Manoj , Singh Ranjit
Published: June 2023

The present research work was done with the objective of topical formulation development of poorly water-soluble drug Mefenamic acid. The drug was firstly incorporated in nanosponge of ethyl cellulose. Then Mefenamic acid nanosponge-loaded topical gel formulations were developed by using Carbopol 934 as a gel-forming polymer. The Mefenamic acid-loaded nanosponges were tested for various quality parameters such as particle size distribution, polydispersity.index(PI),. Surface morphology and drug entrapment efficiency etc. Gel formulations were tested for viscosity, pH, in vitro diffusion and other parameters. The average size of developed nanosponge preparations was found between 250nm to 894nm. Scanning electron microscopy photographs of developed formulations clearly reveal the spongy and porous nature of particles along with spherical shape. The PI was. found in. the range. of 0.206 to 0.934. It was found that formulation N3 with a drug-to-polymer ratio of 1:4 has the highest drug loading. Further nanosponge were characterized for different parameters and results revealed acceptable characteristics of N3 formulation. These prepared nanosponges were loaded in topical Carbopol gel (Formulation G3) and evaluated for in vitro diffusion release. Obtained in vitro data was applied to numerous kinetic models which reveal typical zero order in vitro drug diffusion with prolonged release of Mefenamic acid and therefore it can be effectively used as analgesic and anti-inflammatory formulation.
Formulation and Evaluation of Coleus amboinicus gel
Authors: Saravanan G.
Published: June 2023

Medicinal flora plays an important function in the treatment of many ailments and in the path of the developing globe since they include various bioactive thoughts that have the potential to generate beneficial and/or negative effects. Coleus amboinicusbelongs to Lamiaceae-family which is a semi-succulent perennial plant. The major use of the plant is for Anti-bacterial activity and where it is also used for Analgesic activity and Anti-inflammatory and Anthelmenthitis etc.The aim of this study is to carry out the formulation and evaluation of Coleus amboinicus gel for Anti-inflammatory activity. The dried coarse leaves of Coleus amboinicus were extracted with Ethanol and Distilled water for phytoconstituents and screened for the presence of Alkaloids, Saponins,Terpenoids, Flavonoids and Tannins. Ethanolic extract was taken for the further process of gel formulation since it contains abundant phytoconstituents. Along with specified quantity of Ethanolic extract of Coleus amboinicus, Carbopol 940 and HPMC were added in different ratio to formulate the gel. Allthe prepared Coleus amboinicus gel is evaluated for the physical examinations likes Homogeneity, Consistency and greasiness, grittiness and nature of gel and its characteristics like pH, Viscosity, Spreadability, drug content, extrudability and Invitro Study of Anti-Inflammatory Activity. Among the formulations, the F5 Formulation containing 2.5g of Ethanolic extract of Coleus amboinicus and 0.5g of Carbopol 940 was found to be more promising as it shows betterphysicochemical characteristics and higher Anti-inflammatory activity.
Retrospective Study on the Large for Gestational Age cases from SSBH, Brunei
Authors: San Yi Myat , Lekha Anayath Indu , Than Yee Khin , Khaing Mi Mi , Naz Farah , Ijaz Kanwal , Ara Jahan , Mon Kyaw Ei Mon
Published: June 2023

Introduction: Large-for-gestational-age babies are at high risk for short-term outcomes such as shoulder dystocia, neonatal hypoglycaemia and birth trauma. Macrosomic babies are defined as those with birth weights of >4,000 g, irrespective of gestational age, sex, or country/region-specific differences in mean birth weight and maternal body weight. In the recent past, the rate of large-for-gestational-age [LGA] babies, has increased all over the world. Purpose This study is aimed to investigate the prevalence of macrosomia/LGA in Suri Seri Begawan Hospital (SSBH) and to determine the maternal and fetal outcomes. Methodology: The selected universe for the study is at Suri Seri Begawan Hospital, for the time duration of 2 consecutive years (2018-19). The secondary data is used to calculate a prevalence. Result: The prevalence of 1.9% was found in this study (all >4 kg) and 75% of male babies were born as macrosomia/LGA. 19% of the participants delivered big babies before, and 27% were diabetic in this current pregnancy. 63.6% were delivered by spontaneous vaginal delivery, and there was 1 shoulder dystocia with a 4.1 kg weighed baby. One LSCS wound infection and one vaginal haematoma occurred in this study, although only 21% of babies were admitted to the neonatal unit. Conclusion: The current study draws its conclusion based on the findings that macrosomia/LGAs in SSBH are not as high as like China. Expectant management was practiced in most of the cases and outcome wise is acceptable ensuring our management protocol was safe. Large-for-gestational-age babies are at high risk for shoulder dystocia with brachial plexus injury, which is of great concern for all obstetricians. The management of macrosomia/LGA pregnancy should be individualized by taking into account all maternal and foetal factors as well as all available diagnostic tools. Obstetricians should be vigilant and careful with proper clinical judgement and early recognition of possible complications.
In vitro Antiinflammatory activity of Tamilnadia uliginosa Fruit extract
Authors: Kommu Sudhakar , Eswaraiah M. Chinna , Akhila B. , Pushkara U. , Ramadevi T.
Published: June 2023

Inflammation is part of the body's immune response. There can be four primary indicators of inflammation like pain, redness, heat or warmness and swelling. Plants have the ability to synthesize a wide range of phytochemicals as secondary metabolites which shows anti-inflammatory activity. Inflammation is currently treated by NSAIDs. Unfortunately these drugs cause increased risk of blood clot resulting in heart attacks and strokes. Therefore, the developments of potent anti-inflammatory drugs from the natural products are now under considerations. A natural product of medicinal plants plays a major role to cure many diseases associated with inflammation. The conventional anti-inflammatory drug available in the market produces various side-effects. Due to these side-effects, there is need for the search of newer drugs with less or no side-effects. The present study was carried out to evaluate in vitro anti-inflammatory activity of ethanolic extract of Tamilnadia uliginosa fruit. Finally the study was concluded that the extract showed anti-inflammatory activities.
Tổ chức dạy học dự án chủ đề “Thiết kế hệ sinh thái thủy sinh”, phần Sinh thái học và môi trường, Sinh học 12
Authors: Trương Minh Khải , Lê Thái Minh Long , Tô Minh Trang
Published: June 2023

Dạy học dự án là một phương pháp dạy học tích cực và trong những năm gần đây được thực hiện rộng rãi tại các trường phổ thông với rất nhiều ưu điểm. Phương pháp này giúp học sinh tiếp cận với kiến thức môn Sinh học thông qua các dự án, trong đó dự án phải giải quyết một vấn đề thực tiễn và tạo ra sản phẩm cụ thể. Do đó, thông qua dạy học dự án, giáo viên giúp học sinh định hướng phát triển năng lực và phẩm chất, gắn liền kiến thức sách giáo khoa và thực tiễn. Bài viết này mô tả qui trình tổ chức dạy học dự án chủ đề “Thiết kế hệ sinh thái thủy sinh”, phần Sinh thái học và môi trường, Sinh học 12, là một trong những chủ đề liên quan mật thiết với cuộc sống hiện nay. Chủ đề dự án này được thiết kế để học sinh vận dụng kiến thức giải quyết vấn đề thực tế, cụ thể là thiết kế một hệ sinh thái thủy sinh cân bằng, ổn định theo thời gian, nhấn mạnh phát triển năng lực tìm hiểu thế giới sống và vận dụng kiến thức, kĩ năng đã học cho học sinh lớp 12, đáp ứng yêu cầu của Chương trình giáo dục phổ thông 2018.
Phát triển kỹ năng thực hành Công tác Đội Thiếu niên Tiền phong Hồ Chí Minh cho sinh viên ngành Giáo dục Tiểu học, Trường Đại học Đồng Tháp
Authors: Huỳnh Thị Kiều Trâm
Published: June 2023

Trên cơ sở khảo sát thực trạng và phân tích những khó khăn ảnh hưởng đến kỹ năng thực hành của sinh viên trong quá trình giảng dạy, chúng tôi thực hiện giải pháp nhằm phát triển kỹ năng thực hành Công tác Đội Thiếu niên Tiền phong Hồ Chí Minh cho sinh viên ngành Giáo dục Tiểu học, Trường Đại học Đồng Tháp như: Nâng cao nhận thức cho sinh viên về kỹ năng thực hành công tác đội; Khắc phục ảnh hưởng của các điều kiện đến việc phát triển kỹ năng thực hành công tác đội; Thường xuyên tổ chức các hoạt động về kỹ năng thực hành công tác đội; Phát huy vai trò chủ thể của sinh viên trong quá trình giảng dạy, tổ chức các hoạt động. Thông qua kết quả khảo sát cho thấy sinh viên ngày càng nhận thức được tầm quan trọng và thành thạo kỹ năng thực công tác đội. Điều này có ý nghĩa rất lớn trong việc nâng cao chất lượng đào tạo cho sinh viên ngành giáo dục tiểu học nhằm đáp ứng yêu cầu đổi mới giáo dục phổ thông hiện nay.
Động lực học tập của sinh viên Sư phạm Mỹ thuật Trường Đại học Đồng Tháp
Authors: Nguyễn Đắc Nguyên , Huỳnh Mộng Tuyền
Published: June 2023

Động lực học tập tích cực bên trong sinh viên càng lớn thì thành quả học tập càng cao. Động lực học tập có vai trò vô cùng quan trọng trong phát triển các phẩm chất, năng lực nghề của sinh viên. Bài báo hệ thống hóa cơ sở lý luận về động lực học tập của sinh viên. Khảo sát làm rõ thực trạng động lực học tập của sinh viên Sư phạm Mỹ thuật Trường Đại học Đồng Tháp về nhận thức tầm quan trọng của động lực học tập, các loại động lực học tập của sinh viên, biểu hiện của các động lực học tập, các nguyên nhân ảnh hưởng đến động lực học tập của sinh viên. Những luận cứ lý luận và thực tiễn để làm cơ sở cho đề xuất 5 biện pháp tạo động lực học tập cho Sinh viên Sư phạm Mỹ thuật Trường Đại học Đồng Tháp.
Phát triển mô hình Tổ Nhân dân tự quản gắn với mở rộng dân chủ và thúc đẩy quyền con người trên địa bàn tỉnh Đồng Tháp
Authors: Nguyễn Quang Thành , Võ Thị Tuyết Hoa
Published: June 2023

Chế độ tự quản đã tồn tại từ lâu trong lịch sử phát triển của xã hội Việt Nam. Trải qua thời kỳ Bắc thuộc, nhờ vào yếu tố tự quản làng, xã và sự cố kết cộng đồng đã giúp cho dân tộc ta không bị thế lực xâm lược đồng hoá. Hiện nay, nhiều thiết chế phi nhà nước ra đời với vai trò tập hợp quần chúng nhân dân theo một hoặc một số mục đích cụ thể đã góp phần mở rộng quyền dân chủ, thúc đẩy quá trình thực thi quyền con người, quyền công dân trên thực tế. Mô hình Tổ Nhân dân tự quản trên địa bàn tỉnh Đồng Tháp có tiền thân là Tổ Dân phòng - Khuyến học hình thành vào năm 2007 được đánh giá là một mô hình tự nguyện, tự quản, tập hợp quần chúng nhân dân cùng tham gia vào các hoạt động quản lý nhà nước, quản lý xã hội ở cơ sở. Trong bài viết này, các tác giả khái quát về sự hình thành của mô hình Tổ Nhân dân tự quản; phân tích sự tác động của mô hình này đối với việc phát huy dân chủ, bảo đảm quyền con người, quyền công dân. Qua đó, đề xuất, kiến nghị một số giải pháp nhằm hoàn thiện và phát triển mô hình Tổ Nhân dân tự quản trong thời gian tới.
Hòa giải - đối thoại tại tòa án, những vấn đề lý luận và thực tiễn
Authors: Hồ Ngọc Đô , Phan Thanh Tùng
Published: June 2023

Xã hội ngày càng phát triển đa dạng và phức tạp, nảy sinh nhiều mâu thuẫn, tranh chấp, đề giải quyết các tranh chấp hiệu quả thì nhiệm vụ trọng tâm là cải cách nền tư pháp. Xuất phát từ nhu cầu tất yếu của xã hội cần giải quyết các tranh chấp đa dạng và phức tạp như hiện nay, Quốc hội đã ban hành Luật Hòa giải, đối thoại tại Tòa án năm 2020, có hiệu lực thi hành từ ngày 01 tháng 01 năm 2021, quy định về hòa giải, đối thoại tại Tòa án trước khi đưa các vụ án dân sự ra xét xử theo thủ tục tố tụng. Trong phạm vi bài viết, tác giải tập trung nghiên cứu các quy định mới trong Luật Hòa giải, đối thoại tại Tòa án; phân tích bối cảnh ra đời; vai trò của hòa giải, đối thoại; so sánh với pháp luật của các nước; phân tích, đánh giá một số vấn đề tồn tại liên quan đến hòa giải, đối thoại tại Tòa án. Từ đó, kiến nghị giải pháp hoàn thiện pháp luật, nâng cao hiệu quả hòa giải.
Análisis bifactorial y validez de constructo de la Escala de Percepción de Amenaza exogrupal frente a los inmigrantes VIH positivos en una muestra de adultos peruanos
Authors: Rosario Quiroz Fernando Joel , Yabar Miranda Percy Samuel , Flores Canto Florencio , Perez Saavedra Segundo Sigifredo , Uribe Hernández Yrene Cecilia , Campana Añasco Teresa de Jesús
Published: June 2023

En la actualidad se evidenciado aumento de los desplazamientos provocados por conflictos, persecuciones, falta de oportunidades, seguridad, entre otras razones, inscrementando la población de migrante en países de América Latina. Se destaca los desplazados venezolanos, siendo Perú el segundo país de Latinoamérica con más de esta población de migrantes. Estudios han alertado sobre la desvalorización de los migrantes y especialmente aquellos que vivan con enfermedades infectocontagiosas como es el VIH. Los ciudadanos autóctonos del país receptor, percirbe la presencia del exogrupo como amenazas a sus derechos sociales relacionándose con actitudes negativas, que se ha ido poteciando por los medios de comunicación. Por tanto, es importante realizar estudios que estimen el discernimiento de amenazas exogrupal estrechamente hacia los migrantes. El objetivo evaluar las evidencias psicométricas del instrumento de medición EPAE en una muestra de adultos peruanos frente a los inmigrantes VIH. El análisis de los ítems y de confiabilidad demostró un adecuado funcionamiento a excepción de los ítems 4, 5, 11 y 12. Se propone utilizar el modelo 2, el cual consta de 9 agregados, confirmado por los diferentes índices estadísticos (X2/gl=3.49; WMRM=1.124; NFI=0.993; CFI=0.995; GFI=0.997; RMSEA=0.045; SRMR=0.035). Según los valores del análisis bifactor no existe suficiente evidencia para asumir un factor general, se recomienda trabajar con dimensiones independientes. Es importante la identificación de percepción de amenazas reales, debido a que investigaciones han evidenciado que el estigma asociado con el VIH constituye uno de los mayores obstáculos para la prevención de nuevas infecciones.
Riesgo biológico en el personal de enfermería de la Unidad de Cuidados Intensivos del Hospital Alberto Sabogal Sologuren
Authors: Rojas Salazar Arcelia Olga , Castro Llaja Lindomira , Merino Lozano Alicia Lourdes , Dávila-Morán Roberto Carlos , Llanos de Tarazona Marina Ivercia , Silva Infantes Manuel , Mori Paredes Manuel Alberto
Published: June 2023

Según la Organización Internacional del Trabajo (OIT) se estima que 2,34 millones de personas mueren cada año a causa de accidentes y enfermedades relacionados con el trabajo. Entre las áreas hospitalarias, la unidad de cuidados intensivos (UCI) es considerada como la más tensa, traumática y agresiva, que ha pesar de la pesada rutina de trabajo, los peligros a la que el personal de enfermería (enfermeros, técnicos y asistentes) está continuamente expuesto. No sólo el medio ambiente es insalubre, sino que dada la ocurrencia frecuente de situaciones de emergencia y la alta concentración de pacientes en estado crítico que se someten a cambios en su estado de salud. El personal de enfermería la UCI tienen un mayor riesgo relacionado con los peligros biológicos, ya que están expuestos a organismos infecciosos durante los procedimientos invasivos y no invasivos. En ese sentido, este trabajo busca indagar sobre percepción acerca de la exposición a los riesgos biológicos para las enfermeras que laboran en la UCI en el Hospital Alberto Sabogal Sologuren, Perú. Los resultados llevados con las trabajadoras de la salud de Unidad de Cuidados Intensivos en el Hospital Alberto Sabogal indicaron que en general, las enfermeras de ese centro asistencial hacen uso de buenas prácticas de riesgo, siendo el de mayor prevalecencia (71%) el relacionado con los principios de bioseguridad, y siendo el de menor cuidado (37%), el referente al lavado de las manos antes y después de tener contacto con los pacientes. Es preocupante, que un porcentaje bajo de enfermeras, entre un 5 y 22% respondieron algunas veces a las prácticas de riesgo, siendo un factor importante de contaminación o peligro con su salud.
Implementación de barreras físicas para el control de roedores en residencias familiares periféricas a centros de abastecimiento de alimentos
Authors: Godiño Poma Francisco Cyl , Godiño Poma Milka Gloria
Published: June 2023

Las especies Rattus norvegicus y R. rattus son originarias de Asia y hasta la fecha están presentes en todo el globo junto a los humanos. Estos roedores han introducido microorganismos patógenos como p.ej. Yersinia pestis, Bartonella y hantavirus en muchas áreas geográficas nuevas. Además, las ratas han adquirido nuevos macroparásitos fuera de sus áreas de distribución nativas y actúan como transmisores eficientes de patógenos entre la vida silvestre, animales domésticos, vectores y humanos. Por otro lado, los roedores dañan y contaminan mucha más comida de la que consumen. Cuando roen, dañan las instalaciones de embalaje y almacenamiento utilizadas para almacenar y transportar la comida. Los roedores contaminan los alimentos principalmente a través de sus excrementos, pelo y orina. Especies de ratas comensales como R. rattus y R. norvegicus producen alrededor de 40 excrementos al día cada uno. Si uno solo de estos excremementos se encuentra en su camino hacia los alimentos destinados a humanos existe la posibilidad de que los alimentos serán rechazados por inadecuados y su valor se reducirá significativamente. La finalidad de este trabajo, es disponer de barreras físicas con el fin de controlar la permanencia de roedores en residencias familiares periféricas alrededor de conglomerados de abastecimiento de alimentos en la ciudad de Huancayo, Perú. Los resultados mostrados en esta investigación, diagnosticaron una alta infestación de roedores en área circuncidantes del mercado de la ciudad de Huanuco de acuerdo a las zonas urbanizadas. El 100% de las residencias que se acogieron a los métodos de barrera física para el control de roedores, mostró un mayor impacto en algunas zonificadas que en otras. Este impacto se asoció significativamente con la implementación de barreras físicas.
Seguridad y satisfacción de fumigadores para el control de enfermedades transmitidas por vectores en Arequipa
Authors: Rojas Díaz Marco Andrés , Ferro Díaz Ingrid Lucía , Mayta Mamani Xiomy Laleskha , Rodríguez Giraldez William
Published: June 2023

Las enfermedades transmitidas por vectores (ETV) van en repunte, la seguridad y satisfacción del equipo que trabaja en el área de fumigación son prioridad, ya que son el personal clave y estratégico para hacer frente a estas enfermedades que son un gran problema de la salud pública a nivel mundial. Como objetivo se propuso deteminar el nivel de seguridad y satisfacción de fumigadores para el control de enfermedades transmitidas por vectores en Arequipa durante el primer semestre del año 2022. La investigación fue descriptiva, experimental de corte transversal con una muestra de 58 fumigadores. Como instrumento de recolección de datos se aplicó una encuesta validada por expertos que consta de tres secciones con diversos ítems para describir la muestra, perfil sociodemográfico, actividad ocupacional, uso de equipos de protección personal, condiciones de salud y satisfacción de empleo. Se utilizó el programa Excel para elaborar la base de datos y el programa EPIDAT 3.0 para frecuencias, porcentajes e IC 95%. Como resultado, 74,14% eran del sexo masculino y 25,86% femenino, 70,69% tenían 41 años o más, 70,69% tenían más de 10 años de ambigüedad, 32,76% tenían unión de hecho, 48,28% tenían estudios secundarios, por otra parte, 94,83% de colaboradores expuestos a Deltametrina <1 hora en dilución y carga, usan mascarillas y filtros, 86,21% usan guantes, bragas y delantales y 84,48% usa gafas, 53,45% sentían sensación de naúseas o mareos, 93,10% estaban satisfechos con el ambiente laboral. Como conclusión, se hace necesario continuar con investigaciones semejantes en diferentes zonas de Perú.
Métodos de exclusión de murciélagos hematófagos en edificaciones humanas
Authors: Godiño Poma Milka Gloria , Godiño Poma Francisco Cyl
Published: June 2023

Los murciélagos son los únicos mamíferos capaces de volar, y también son un grupo diverso, dentro de los cuales se han identificado 1.116 especies, 202 géneros y 18 familias. Geográficamente, se distribuyen en casi todo el mundo, con excepción del polo Norte y Sur. Existen al menor tres especies de murciélagos hematófagos, las cuales solo habitan en el continente americano: el vampiro de patas peludas (Diphylla ecaudata), el alas blancas (Diaemus youngi), que tienen preferencia por el consumo de sangre de aves, y el vampiro común (Desmodus rotundus), único de estas especies que se alimenta de sangre de mamíferos, incluyendo humanos, siendo ésta la especie de mayor importancia desde un punto de vista sanitario y económico. Es importante destacar que una variedad de nuevas enfermedades infecciosas zoonóticas ocurridas en los últimos años se ha relacionado con los murciélagos. A pesar de ser portadores de diversas enfermedades, también tiene un lado positivo que señala su importancia en la naturaleza, destaca que, debido a su alta sensibilidad a los cambios climáticos, son considerados como buenos indicadores del estado de conservación de bosques. Además, aportan a la diversidad estructural y funcional de los bosques siendo dispersadores de semillas, polinizadores de plantas y controladores de plagas. Por lo tanto, este trabajo tiene como finalidad, el uso de métodos físicos para la exclusión de murciélagos hematófagos que habitan en la zonificación de San Remo, del sector la Molina en Lima, Perú. Posterior a a un diagnóstico inicial, se implementaron los métodos de barrera física, tales como mallas, cortinas o tubos de PCV que impedieron la pernotación de los murciélagos en los hogares zonificados encontrándose una reducción de los índices de infestación.