bluuebunny/crossref_metadata_2025 huggingface dataset:
Ультрамикроскопические особенности главных клеток околощитовидных желез крыс после 60-ти дневного воздействия бензоата натрия
Authors:   Кафедра анатомии и гистологии человека, ФГАОУ ВО «Белгородский государственный национальный исследовательский университет», Морозов Виталий , Морозова Елена ,   Кафедра анатомии и гистологии человека, ФГАОУ ВО «Белгородский государственный национальный исследовательский университет»
Published: June 2022

Одним из консервантов с антибактериальными и антигрибковыми свойствами является пищевая добавка Е211 – бензоат натрия, которая находит широкое применение в пищевой, фармацевтической промышленности и косметологии. При этом, остается неоднозначным вопрос о его безопасности в отношении здоровья человека. Практически не изученным является влияние длительного введения бензоата натрия на морфофункциональные особенности эндокринных желез, в частности, практически полностью отсутствует информация, касающаяся морфологических изменений околощитовидных желез в данных условиях. В связи с этим, целью исследования является оценить ультрамикроскопические изменения главных клеток околощитовидных желез половозрелых крыс после 60-ти дневного введения бензоата натрия.
Solution of a local boundary problem for a non-linear non-stationary system in the class of discrete controls
Authors:   St. Petersburg State University, Kvitko Aleksandr N. , Litvinov Nikolay N. ,   St. Petersburg State University
Published: June 2022

This article proposes an algorithm of construction for the discrete controlling function which is restricted by a norm and provides transition for the wide class of the systems of nonstationary nonlinear ordinary differential equations from the initial state to the setting final state. A constructive sufficient condition that provides this transition is obtained. Efficiency of the method is demonstrated by the solution of the robot-manipulator control problem and its numerical modeling.
On the effective elastic properties of a material with mutually perpendicular systems of parallel cracks
Authors:   St. Petersburg State University, Abakarov Abdulla M. , Pronina Yulia G. ,   St. Petersburg State University
Published: June 2022

The effective properties of cracked solids are often expressed in terms of the crack density parameter or its tensor generalization, using the approximation of noninteracting cracks. This approximation remains accurate at sufficiently high crack densities, provided the location of cracks are random. The presented analysis confirms that the effective elastic moduli of a material with ordered fracture structures strongly depend on the linear dimensions of cracks and their mutual arrangement even at a constant crack density. A change in these parameters can cause a noticeable anisotropy of the effective properties of the material even when the eigenvalues of the crack density tensor are equal to each other. The effective elastic characteristics of a material with one doubly periodic system of parallel cracks are compared with those for a material with two mutually perpendicular systems of such cracks in a two-dimensional formulation. The calculations are carried out using the approximate method of M. Kachanov for determining the mean stresses at the cracks edges, applicable for large systems of interacting cracks. Analysis of the obtained results showed that the effective compliance of the material in a certain direction is largely determined by the effects of interaction (shielding and amplification) within a system of parallel cracks perpendicular to this direction. The interaction of this system of cracks with the perpendicular system has a weak effect on the indicated properties in the case of rectangular symmetry of the system. In this case, the interaction of mutually perpendicular systems of cracks leads to a violation of the symmetry of the tensor of effective elastic constants.
Quality criteria for control of epidemic process
Authors:   St. Petersburg State University, Miheev Sergey E. , Mikheev Vikenty S. ,   Kansas State University
Published: June 2022

The total number of those infected at the end of an epidemic and the maximum number of infected during an epidemic are considered as two quality criteria for control by delayed isolation of the SIR- and SIRS-type infections. The temporal Barabasi Albert graph is used to model the contacts between individuals. Simulations are run to estimate optimal delays.
Rate of spontaneous polyploidization in haploid yeast Saccharomyces cerevisiae
Authors: Andreychuk Yulia , Zhuk Anna , Tarakhovskaya Elena , Inge-Vechtomov Sergei , Stepchenkova Elena
Published: June 2022

Polyploidization is involved in a variety of biological processes. It is one of the principal mechanisms of new species formation since it provides material for gene diversification and subsequent selection. Multiple cases of polyploidization were registered in different branches of the evolutionary tree of eukaryotes. Besides its role in evolution, polyploidization affects gene expression in living cells: pathological genome duplications often happen in cancer cells. The mechanisms and consequences of polyploidization are being studied extensively. However, quantitative determination of the polyploidization rate is challenging due to its low frequency and the absence of selective genetic markers that would phenotypically distinguish between haploids and polyploids. Our work describes a robust and straightforward method for discriminating haploid and polyploid states in the yeast Saccharomyces cerevisiae, a model organism for studying different aspects of polyploidization. The measurement of polyploidization rate showed that in yeast cells this process is mainly caused by autodiploidization rather than mating-type switching followed by hybridization.
WITHDRAWN: Antihyperglycemic Activity, Histopathological Change in
Type II Diabetic Rat, and Simultaneous Determination of Kaempferol and
Quercetin in Foxtail Millet (Setaria italica (L.) Beauv.) by Validated Highperformance
Thin-Layer Chromatography
Authors: Singh Divya , Mukherjee Alok , Lawrence Kapil
Published: June 2022

The article has been withdrawn at the request of the editor of the journal Current Drug Delivery (CDD).

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

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of their article is transferred to the publishers if and when the article is accepted for publication.
Aminopeptidases in Cancer, Biology and Prospects for Pharmacological
Intervention
Authors: Lehmann Fredrik , Holstein Sarah A. , Heckman Caroline A. , Davies Faith E. , Morgan Gareth J. , Gelius Stefan Svensson
Published: June 2022

Aminopeptidases, which catalyze the cleavage of amino acids from the amino terminus of
proteins, are widely distributed in the natural world and play a crucial role in cellular processes and
functions, including metabolism, signaling, angiogenesis, and immunology. They are also involved
in the homeostasis of amino acids and proteins that are required for cellular proliferation. Tumor
cells are highly dependent on the exogenous supply of amino acids for their survival, and overexpression
of aminopeptidase facilitates rapid tumor cell proliferation. In addition, clinical studies have
demonstrated that patients with cancers with high aminopeptidase expression often have poorer outcomes.
Emerging evidence supports the rationale of inhibiting aminopeptidase activity as a targeted
approach for novel treatment options, as limiting the availability of amino acids can be selectively lethal
to tumor cells. While there are agents that directly target aminopeptidases that demonstrate potential
as cancer therapies, such as bestatin and tosedostat, more selective and more targeted therapeutic
approaches are needed. This article specifically looks at the biological role of aminopeptidases
in both normal and cancer processes, and their potential as a biological target for future therapeutic
strategies.
When examining previous publications, most do not cover aminopeptidases and their role in cancer
processes. Aminopeptidases play a vital role in cell processes and functions; however, their overexpression
may lead to a rapid proliferation of tumor cells. Emerging evidence supports the rationale of
leveraging aminopeptidase activity as a targeted approach for new oncological treatments. This article
specifically looks at the biological role of aminopeptidases in both normal and cancer processes,
and their potential as a biological target for future therapeutic strategies.
Association of Inflammatory Biomarkers and Cardiovascular Risk Scores
in an Italian Cohort of HIV Positive Patient Undergoing Antiretroviral
Therapy
Authors: Katia Falasca , Claudio Ucciferri , Antonio Auricchio , Marcella Reale , Erica Costantini , Jacopo Vecchiet
Published: June 2022

Background:

Several algorithms have been developed to predict cardiovascular risk (CVR) over time, however none of them seem to be accurate when applied to HIV patients.

Objective:

The aim of this study was to assess plasma inflammatory biomarkers in relation to multiple CVR scores (FRS, ASCVD, PROCAM and the DAD-5 Years-Estimated-Risk) in an Italian cohort of HIV patients undergoing a combined Antiretroviral Therapy (cART).

Methods:

We enrolled HIV patients undergoing cART without any change in the HIV-related pharmacological therapy over the last 48 weeks Demographic and anamnestic data were collected, and a biochemical panel including the following biomarkers was collected: CRP, Cystatin-C, microalbuminuria, IL-18, IL-2, IL-4, IL-6, IL-10, TNF-α and IFN- γ. CVR scores were obtained for each patient and compared to the biochemical panel to assess statistical correlation.

Results:

90 Caucasian HIV patients were enrolled. Assessment of CVR scores showed FRS values of 6.98±6.11%, ASCVD 7.18±6.25%, PROCAM 6.7±7.4% and DAD-5 Years Estimated Risk 3.10±3.41%. We found correlations between the levels of circulating cytokines measured and the cardiovascular risk prediction scores.

Conclusions:

Our data showed that the values of selected inflammatory biomarkers strongly correlate with the CVR scores, suggesting that they can be employed as reliable predictors of cardiovascular disease in HIV patients. The routine use of selected biomarkers associated with systemic inflammation could be a valid and readily available tool for clinicians to assess and monitor cardiovascular risk in HIV patients.
Physical Instabilities of Therapeutic Monoclonal Antibodies: A Critical
Review
Authors: Mehta Priti , Bana Arpit Arun K. , Ramnani Khushboo Ashok Kumar
Published: June 2022

The proteinaceous nature of monoclonal antibodies (mAbs) makes them highly sensitive to
various physical and chemical conditions, thus leading to instabilities that are classified as physical
and chemical instabilities. In this review, we are discussing in detail the physical instability of mAbs
because a large number of articles previously published solely focus on the chemical aspect of the instability
with little coverage on the physical side. The physical instabilities of mAbs are classified into
denaturation and aggregation (precipitation, visible and subvisible particles). The mechanism involved
in their formation is discussed in the article, along with the pathways correlating the denaturation of
mAb or the formation of aggregates to immunogenicity. Further equations like Gibbs-Helmholtz involved
in detecting and quantifying denaturation are discussed, along with various factors causing the
denaturation. Moreover, questions related to aggregation like the types of aggregates and the pathway
involved in their formation are answered in this article. Factors influencing the physical stability of the
mAbs by causing denaturation or formation of aggregates involving the structure of the protein, concentration
of mAbs, pH of the protein and the formulations, excipients involved in the formulations,
salts added to the formulations, storage temperature, light and UV radiation exposure and processing
factors are mentioned in this article. Finally, the analytical approaches used for detecting and quantifying
the physical instability of mAbs at all levels of structural conformation like far and near UV, infrared
spectroscopy, capillary electrophoresis, LC-MS, microflow imagining, circular dichroism and peptide
mapping are discussed.
Computational Investigation of the Interaction of Novel Indene Methylene
Analogues with Acetylcholinesterase from Both Dynamic and Thermodynamic
Perspectives
Authors: Gupta Shraddha M. , Jain Neetesh K. , Yadav Rohitash , Erol Meryem , Celik Ismail , Gupta Manish , Behera Ashok
Published: June 2022

Background:

Torpedo californica acetylcholinesterase (TcAChE) is an important drug development
target for Alzheimer's disease (AD) therapeutics. The current in silico study aims to recognise indene
methylene-derived compounds acting against TcAChE to gain insight into the molecular interactions.

Objective:

The current study focused on identifying novel inhibitors for Torpedo californica acetylcholinesterase
(TcAChE) by virtual screening, molecular docking, drug-likeness, molecular simulation, and
DFT profile for anti-Alzheimer's activity.

Methods:

Molecular docking, ADMET screening, molecular simulation, and DFT were performed for
drug development having anti-Alzheimer's activity related to Torpedo californica acetylcholinesterase
(TcAChE).

Results:

On the AutoDock Vina algorithms, ligands SD-24 [-12.6, -13.1 kcal/mol], SD-30 [-12.5, -12.6
kcal/mol], SD-42 [-11.8, -12.5kcal/mol] showed promising docking and confirmatory redocking scores
compared to Donepezil [-8, -10.9 kcal/mol], followed by ADMET screening. The best three complexes
were subjected to molecular dynamics simulations (MDSs) over 30 ns to understand the TcAChE dynamics
and behavior in a complex with the ligand. MEP and NBO analysis was performed for the
DFT/B3LYP theory and 6-311G [d,p] base set and Gaussian 09 package program. For MDSs, the root
means square (RMSD) parameter remained stable for 30 ns at 0.25 nm. The ligand-AChE complex
formed 2 to 4 satisfactory intermolecular H bonds, which substantiated the stability of the three compounds
in the protein binding cluster as potent binders. The LUMO (owest unoccupied molecular orbital)-
HOMO (highest occupied molecular orbital) energy gap of the SD24, SD30, and SD42 compounds was
4.0943, 4.2489, and 4.2489 eV, respectively, and stability was ordered as SD24>SD30=SD42.

Conclusion:

The outcome of in silico studies suggests that SD24, SD30, and SD42 compounds have
promising drug-likeness, simulation, and DFT profiles for anti-Alzheimer's activity. However, in vitro
and in vivo studies are required to confirm their biological activities.
Incidence, Current Guidelines and Management of Gastrointestinal Bleeding
after Transcatheter Aortic Valve Replacement: A Systematic Review
Authors: Doshi Rajkumar , Adalja Devina , Zala Harshvardhan , Victor Varun , Sheth Aakash , Willyard Charles , Suzuki Emi , Patel Harsh P. , Majmundar Monil , Vallabhajosyula Saraschandra
Published: June 2022

Background:

There is a significant increase in morbidity and mortality in patients complicated
by major bleeding following transcatheter aortic valve replacement (TAVR). It has become
more challenging to manage such complications when the patient needs to be on anticoagulation
or antiplatelet agent post-procedure to prevent thrombotic/embolic complications.

Methods:

We systematically reviewed all available randomized controlled trials and observational
studies to identify incidence rates of gastrointestinal bleeding post-procedure. After performing a
systematic search, a total of 8731 patients from 15 studies (5 RCTs and 10 non-RCTs) were
included in this review.

Results:

The average rate of gastrointestinal bleeding during follow-up was 3.0% in randomized
controlled trials and 1.9% among observational studies.

Conclusion:

Gastrointestinal bleeding has been noted to be higher in the RCTs as compared to observational
studies. This review expands knowledge of current guidelines and possible management
of patients undergoing TAVR.
Structure-based in silico and in vitro Analysis Reveals Asiatic Acid as Novel
Potential Inhibitor of Mycobacterium tuberculosis Maltosyl
Transferase
Authors: Sharma Rolee , Singh Kratika , Sharma Akanksha , Upadhyay Tarun Kumar , Hayat-ul-Islam Mohammad , Khan M. Kalim A. , Dwivedi Upendra N.
Published: June 2022

Aims:

The present study aimed to search for novel potent inhibitor(s) against the recently discovered maltosyltransferase (GlgE) target of M.tb.

Background:

GlgE belongs to an α-amylase family and catalyzes the elongation of cytosolic branched α-glucan. Inactivation of M.tb.GlgE results in DNA damage and rapid death of M.tb. due to the accumulation of a toxic altosyl donor, maltose-1-phosphate (M1P), suggesting that GlgE is an intriguing target for inhibitor design.

Method:

1000 natural compounds were compiled from public databases and literature through virtual screening, of which 25 compounds were found to satisfy all drug-likeness properties and ADME/toxicity criteria, followed by molecular docking with GlgE. Compound(s) showing the lowest binding energy was further subjected to molecular dynamics simulation (MDS) and in vitro analysis.

Results:

Molecular docking analysis allowed the selection of 5 compounds showing significant binding affinity to GlgE targets. Amongst these compounds, asiatic acid exhibited the lowest binding energy (-12.61 kcal/mol). The results of 20-ns MDS showed that asiatic acid formed a stable complex with GlgE. Additionally,asiatic acid exhibited in vitro anti-mycobacterial activity against M.tb. H37Ra, M. bovisBCG, and M. smegmatisstrains.

Conclusion:

The study reveals Asiatic acid as a promising anti-mycobacterial agent that might emerge as a novel natural anti-TB lead in the future.
Effect of Nano-Curcumin on Radiotherapy-Induced Skin Reaction in
Breast Cancer Patients: A Randomized, Triple-Blind, Placebo-Controlled
Trial
Authors: Farhood Bagher , Najafi Masoud , Talakesh Tamara , Tabatabaee Nasibeh , Atoof Fatemeh , Aliasgharzadeh Akbar , Sarvizade Mostafa
Published: June 2022

Purpose:

Despite advances in medical technology, radiation-induced dermatitis occurs in 95% of cancer patients receiving radiation therapy. Currently, there is no standard and effective treat-ment for the prevention or control of radiation dermatitis. The aim of this study was to determine the efficacy of nano-curcumin in alleviating the radiation-induced skin reactions (RISRs) in breast cancer patients.

Methods:

A randomized, triple-blinded, placebo-controlled clinical trial was performed on 42 patients with breast cancer. The patients were randomly allocated to receive radiotherapy plus placebo (control group) and radiotherapy plus 80 mg/day nano-curcumin capsules (treatment group) up to two weeks after the end of treatment. Then, the RISRs (graded by the radiation therapy oncology group (RTOG) scale) and pain level of the patients were evaluated at baseline and weekly. Finally, the results were analyzed by T-test and Pearson chi-square test.

Results:

According to the RTOG scale, 0%, 14.28%, and 85.71% of patients in the control group showed grades 0, 1, and 2 RISRs, respectively. In the treatment group, it was observed that 9.52%, 47.61%, and 42.85% of patients had grades 0, 1, and 2 RISRs, respectively. Compared to the control group, it was found that concomitant use of the nano-curcumin supplement did not significantly reduce the RISR severity during the first to sixth weeks (P > 0.05); however, there was a significant difference at week 7 (P = 0.01). Moreover, the patient-reported pain, as the secondary endpoint, was significantly reduced in the treatment group compared with the control group (P < 0.05).

Conclusions:

In general, it was found that the administration of nano-curcumin could alleviate radia-tion-induced skin toxicity of breast cancer patients, but this effect was not significant.

Trial Registration Number:

Registered in the Iranian Registration of clinical trials (IRCT2020051304-7427N1).
Effect of Solvents, Drug/Polymer Ratio and Surfactant Concentration on In Vitro Characteristic of Repaglinide Loaded Poly (Meth) Acrylate Nanoparticles
Authors: Lokhande A. , Mishra S. , Kulkarni R. , Naik J.
Published: June 2022

In the present work Repaglinide loaded ammonio methacrylate copolymer nanoparticles were developed by modified solvent emulsion technique using high pressure homogenizer. An effect of numerous organic solvents, surfactant concentration, drug-polymer ratios and combination of polymers on encapsulation efficiency as well as drug release profile were studied. Sustained released nanoparticles were obtained in the size of less than 400 nm. FE-SEM showed smooth and rigid surface of Eudragit RS nanoparticle’s while porous surface nature was observed in Eudragit RL nanoparticles. No drug-polymer interaction was found. X-RD revealed that the crystallinity of repaglinide was decreased when processed with Eudragit polymers. Eudragit RSPO retained drug for more time than other copolymers. Most of the formulations followed zero order kinetics. Prepared nanoparticles can be used for the treatment of type 2 diabetes mellitus by minimizing dose rate, reducing adverse effects and enhancing patient fulfillment.
¿Cómo se habita el hábitat? Los modos de habitar
Authors: Saldarriaga Roa Alberto
Published: June 2022

El objetivo de este artículo es ampliar el entendimiento de “los modos de habitar”, con base en la investigación previa titulada “Hábitat y Arquitectura en Colombia. Los modos de habitar”. En particular, se centra en una reelaboración del planteamiento conceptual que se propuso en ese libro y en ese momento. En este texto, se trabajan cuatro conceptos básicos: hábitat, habitar, cultura y arquitectura, y se estudia el papel que desempeñan en la construcción de los modos de habitar, cuya síntesis se expone en la sección conclusiva. Se incluyen al final dos ejemplos tomados de la literatura sobre el período prehispánico, y sobre el siglo IXI, para dar a entender cómo el tema de los modos de habitar puede leerse en una de las posibles aproximaciones al tema.
A Comparison of the Effects of Stochastic Resonance Therapy, Whole-Body Vibration, and Balance Training on Pain Perception and Sensorimotor Function in Patients With Chronic Nonspecific Neck Pain: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Igbokwe Emmanuel Osinachi , Taube Wolfgang , Beinert Konstantin
Published: June 2022

BACKGROUND

Neck pain is a prevalent pathological condition, and together with low back pain, it presents as the leading cause of years lived with disability worldwide in 2015 and continues to contribute substantially to the global burden of disease.

OBJECTIVE

This study will investigate and compare the effects of stochastic resonance therapy (SRT), whole-body vibration (WBV), and balance training (BLT) in the management of chronic nonspecific neck pain.

METHODS

In total, 45 participants with chronic neck pain will be randomly allocated into SRT, WBV, and BLT groups. Pain intensity, pressure pain threshold, neck disability, and cervical joint position sense will be measured before, immediately after, and 15 minutes after the first intervention session and after 4 weeks of intervention. A follow-up postintervention measurement would be taken after 4 weeks. The SRT group will train on an SRT device (SRT Zeptor Medical plus noise, Zeptoring). The WBV group will train on a Galileo vibration device (Novotec Medical), while the BLT group will perform balance exercises. All participants shall train 3 times a week for a period of 4 weeks. Mixed ANOVA will be used to determine the main and effects of interactions within (before intervention, post intervention 1, post intervention 2, post intervention 3, and follow-up) and between (SRT, WBV, and BLT) factors on the study outcome variables.

RESULTS

Recruitment of participants started in May 2021, and as of May 2022, a total of 20 patients have been enrolled in the study. All participants are expected to have completed the trial by the end of 2022, and data analysis will commence thereafter.

CONCLUSIONS

The outcome of this study will shed closer light on the effects of SRT, WBV, and BLT on pain and function in patients with chronic neck pain.

CLINICALTRIAL

German Clinical Trials Register DRKS00023881; https://tinyurl.com/ycxuhj37

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/34430
Understanding the technological landscape of home health aides: a scoping literature review and a landscape analysis of existing mHealth Apps (Preprint)
Authors: Kuo Elizabeth Fong-Chy , Cho Jacklyn , Olaye Iredia , Delgado Diana , Dell Nicola , Sterling Madeline R
Published: June 2022

BACKGROUND

Home health aides (HHAs) provide necessary hands-on care to older adults and those with chronic conditions in their homes. Despite their integral role, HHAs experience numerous challenges on the job, including their ability to communicate with other healthcare professionals about patient care while caring for patients and accessing educational resources. While technological interventions have the potential to address these challenges, little is known about the technological landscape and existing tech-based interventions designed for and used by this workforce.

OBJECTIVE

We conducted a scoping review of the scientific literature to identify existing studies which have described, designed, deployed, and/or tested technology-based tools and apps intended for use by HHAs to care for patients in the home. To complement our literature review, we conducted a landscape analysis of existing mobile apps intended for HHAs providing in home care.

METHODS

We searched the following databases from inception to October 2020: Ovid MEDLINE, Ovid EMBASE, Cochrane Library, and CINAHL (EBSCO). Three researchers screened the yield using pre-specified inclusion and exclusion criteria. Four researchers then independently reviewed these articles and a fifth arbitrated when needed. Among studies that met the inclusion criteria, data were extracted and summarized narratively. An analysis of mHealth apps designed for HHAs was performed using a predefined set of terms to search the Google Play Store and Apple App Store. Two researchers independently screened the resulting apps and those that met the inclusion criteria were categorized according to their intended purpose and functionality.

RESULTS

Of the 8,643 studies retrieved, 182 underwent full-text review, and 9 met our inclusion criteria. Half (n=4) were descriptive in nature, proposing technology-based systems (e.g., web-portal, dashboard) and/or prototypes without a technical or user-based evaluation of the technology. In most papers (n=7), HHAs were just one of several users and not the sole/primary intended user of the technology. Our review of mobile apps yielded 166 Android and iOS apps, of which 48 met the inclusion criteria. These apps provided HHAs with one or more of the following functions: electronic visit verification (29), clocking in and out (23), documentation (22), task checklist (19), communication between HHA and agency (14), patient information (6), resources (5), and communication between HHA and clients (4). Overall, of the 48 apps, 25 performed monitoring functions, 4 supporting functions, and 19 did both.

CONCLUSIONS

A limited number of studies and mobile apps are designed to support HHAs on the job. Further research and rigorous evaluation of technology-based tools are needed to assess their impact on the work HHAs provide in patient’s homes.
The role of association of ADRB2 gene polymorphism with therapeutic response to β2-agonists in children with recurrent bronchial obstruction
Authors: Karimdzhanov I.A. , Zakirova U.I. , Yusupova G.A. , Karimova U.N.
Published: June 2022

Background. The study of the effect of drugs at the molecular genetic level in the recurrent course of bronchial obstruction (RBО) in children improved the understanding of the pathogenesis of the disease and made it possible to better characterize the reliability of use in therapy. The aim of the study was to assess the clinical significance of the polymorphism of the Arg16Gly loci of the ADRB2 gene with a therapeutic response to β2-agonists in children with RBО of Uzbek ethnicity. Materials and methods. Tested 88 patients aged 6 to 15 years with recurrent bronchial obstruction and bronchial asthma with the polymorphism of the ADRB2 gene loci and determined the effectiveness of salbutamol in these groups of patients. Results. Results of the study of the significance of the polymorphism of the Arg16Gly locus of the ADRB2 gene with a therapeutic response to β2-agonists in children with RBO showed high efficacy of salbutamol in 72.9 % of children, among whom representatives of the A/G and A/A genotypes were found in the largest number. At the same time, the low efficacy of salbutamol was found in the greatest amount in carriers of the mutational genotype G/G of the Arg16Gly locus of the ADRB2 gene. Conclusions. The predictor role of the polymorphic locus rs1042713 (Arg16Gly) was determined in carriers of the unfavorable 46G allele of the G/G genotype of the ADRB2 gene, which was a genetic marker of children’s predisposition to RBO and BA in children. Children with the G/G genotype of the Arg16Gly locus of the ADRB2 gene are at risk for severe RBO and BA in children. Children with RBO carriers (Arg16Gly) of the homozygous G/G genotype have a high incidence of RBO recurrence against the background of ARVI and are at risk of developing BA.
Association of Serum 25(OH)D Deficiency with High Viral Load in HBV Infected Patients
Authors: Amien Nada Mohamed Hassan , Alameen Ayman Ali Mohammed , Junaid Kashaf , Abdalla Abualgasim Elgaili , Awadelkarim Mona O.A. , Siddig Hind M. , Bilal Naser Eldin
Published: June 2022

Hepatitis B virus (HBV) is a significant public health concern, particularly in low-income countries. The host immune response plays an essential role in hepatitis B virus outcome, mainly orchestrated by cytokines and immune modulators molecules such as vitamin D. This study aimed to determine the levels of cytokines (IL-10), interferon-gamma (IFN-gamma), interferon-lambada (IFN-lambada), granzyme B, and vitamin D in Khartoum, Sudan, and to assess the association between them and variable HBV viral load as well as liver enzyme levels. A total of 174 participants were enrolled in the trial, with 100 HBV-infected patients (who were HIV and HCV negative) and 74 healthy volunteers. Patients’ HBV viral load, vitamin D levels, liver enzymes, and circulatory cytokines were measured. This study revealed a remarkable decrease in vitamin D levels in HBV infected patients with an elevation in levels of liver biomarkers. The level of IL-10 was significantly higher in patients than in apparently healthy controls (p-value <0.001). There was a positive correlation between IFN-ϒ, Granzyme B, and viral load. According to the findings of this study, there is a marked hypovitaminosis D among hepatitis B infected patients with a significant increase in IL-10, which may implicate the persistence of HBV infection. Moreover, HBV DNA levels were significantly associated with IFN- g and granzyme B levels.
Network Intrusion Detection System Using Machine Learning with Data Preprocessing and Feature Extraction
Authors: Pallepati Manvith
Published: June 2022

Abstract: Unauthorized access to a computer network can be discovered by scanning the network traffic for evidence of malicious activity, which is what Network Intrusion Detection (NID) does. However, in this study, we will concentrate on the technology, development, and strategic importance that make up the large field of Network Intrusion Detection (NID). Many new strategies have been created in the last few years to help computer security specialists in protecting a single host or an entire network against unauthorized access, theft, and denial-of-service assaults, which are the primary causes of computer crime. Intrusion Detection is critical for both the military and commercial sectors since it is the most significant study area for the future networks' Information Security. In this paper, a model is being proposed, where the data is preprocessed before training with the algorithms. A study done by comparing with other models shows that, the current model built with Random Forest can outperform other existing models built with ANN when the data is preprocessed. After building model after data pre-processing and feature extraction, we are able to achieve 98.71% accuracy on NSL-KDD dataset.
Fashion Recommendation System
Authors: K Aneesh
Published: June 2022

Abstract: Artificial intelligence is becoming increasingly useful in creating personalized shopping experiences on e-commerce websites, user-specific advertisements, classifying objects, and detecting colors from images. Fashion is one of the most critical industries in our world today. Style has become one of the primary ways in which people express their personality and in which they distinguish themselves from those around them. In this project, we are creating a Fashion Recommendation System using Artificial Intelligence inorder to classify the user’s clothes and recommend the most suitable outfit for a given occasion using a recommendation algorithm. The proposed system shows that it can process the user’s clothes from the images, identify the type and color of the outfit and finally recommend the most suitable outfit for the given occasion based on the user’s existing clothes. The system provides a wardrobe, whereusers can store images of clothes that they have. Each user is associated with a wardrobe. We explore machine and deep learning techniques to classify the type of clothes from images and to identify the color of the clothes. Finally, we propose an algorithm that is used to recommend matching clothes.
Smart Wheelchair Based on IoT for Disabled and Elderly People
Authors: Lakshmi Anantha Rushitha
Published: June 2022

Abstract: Pervasive devices are becoming an integral part of people's daily lives. Smart gadgets make people's lives easier and are becoming an essential part of the lives of physically tested and matured people. The need for safe and unrestricted mobility for the elderly and physically challenged is critical. The study deals with the creation of an Intelligent Wheel-Chair (IWC) that focuses on a certain issue in an exceptionally moderate and prominent manner.Wheel-Chair is controlled by RTOS as its center working framework. It comprises of touchscreen based route navigation alongside obstacle avoidance and fall identification. As a result with voice command movement of the wheel chair is dependent which will help disable and old aged people. The Node MCU used successfully detected the commanded and he Arduino micro-controller used in this project has successfully delivered its purpose.
Generating Report of Bone Fracture and Bleeding using X-ray Images
Authors: P Anand
Published: June 2022

Abstract: The bone is a major component of the human body. Bone provides the ability to move the body. The bone fractures are common in the human body. The doctors use the X-ray image to diagnose the fractured bone. Therefore, an automated system needs to develop to diagnose the fractured bone The Deep Neural Network (DNN) is widely used for the modelling of the power electronic devices. This study showed that a deep learning model can be trained to detect fractures in radiographs with diagnostic accuracy similar to that of senior subspecialized orthopaedic surgeons. The aim of this study is to perform fracture detection by use of deep-learning on X-ray images to support physicians in the diagnosis of these fractures, particularly in the emergency Services. Hospitals, especially their emergency services, receive a high number of fracture cases. For correct diagnosis and proper treatment of these, images obtained from various medical equipment must be viewed by physicians, along with the patient’s medical records and physical examination. Recent advancement in image processing and deep learning create some hopes in devising more enhanced applications. Therefore, data augmentation techniques have been used to increase the size of the data set
TEKSTİL KULLANILAN SANAT ESERLERİNDE TOPLUMSAL CİNSİYET KAVRAMININ ARAŞTIRILMASI
Authors: AKDEMİR İrem , KORKMAZ F. Deniz
Published: June 2022

Toplumsal cinsiyet, toplum tarafından benimsenmiş kültürel kodların, kalıplaşmış yargıların bir sonucu olarak kadın ve erkekten beklenen tutum ve davranışlardır. Kavram olarak 1960’lardan sonra kullanılmaya başlanmıştır. Aynı döneme denk gelen feminist hareket ile toplum gündemini meşgul etmeye başlamış ve tanınırlık kazanmıştır. Günümüzde hala güncelliğini koruyan bir konudur. Çalışmada, geçmişten günümüze sanatçıların eserlerinde kadın ve kadın oluş mefhumunu ne şekilde, hangi konulara vurgu yaparak ele aldıkları ve bunu tekstil ile ne şekilde ilişkilendirdiklerini irdelemek amaçlanmıştır. Söz konusu alanda yaşanan değişimlerin/değişmezliklerin ne olduğunun, zihinlerde oluşan kadın algısının eser üretimlerine ne şekilde tezahür ettiğini açıklamak hedeflenmektedir. Konu ile ilgili literatür taraması yapılarak toplumsal cinsiyet kavramının sanat alanında gelişimi ve ifade biçimleri örneklerle açıklanmıştır. Bu çerçevede çalışmada ulusal ve uluslararası çağdaş sanat alanında kabul görmüş sanatçıların, kadın ve kadın oluş mefhumu çerçevesinde tekstil malzemesi kullanılarak üretilmiş sanat eserlerine yer verilmiştir. Araştırmanın sonucunda, sanatçıların eserlerinde bedene özgü içerikler ve kadınla özdeşleşen nesneleri yoğun bir şekilde kullandığı görülmüştür. Tekstil ise eserlerdeki ifade biçimine göre sanatçılara metaforik anlatım imkânı sunmuştur.
La ilusión del mérito. Capital cultural y reproducción
Authors: Grau-Grau Marc
Published: June 2022

Celebrando el 50 aniversario de la publicación de La Reproducción (Bourdieu and Passeron, 1970), y ante el auge del proyecto meritocrático en muchas esferas de nuevas vidas,  el objetivo del presente estudio es comprender la percepción del esfuerzo, y el talento, en la obtención de la posición de trabajo actual, ayudando a desvelar como la incorporación de distintos capitales a lo largo de la vida (estructuras de primer orden) construye la percepción del propio mérito como elemento explicativo del logro del último empleo. Para ello el estudio examina las respuestas de 2482 entrevistas a españoles de más de 18 años de 255 municipios en 50 provincias (Estudio CIS nº 3176. Desigualdad y movilidad social), usando el análisis de correspondencia múltiple, no sólo para recuperar una técnica estadística muy apreciada por Bourdieu sino también por su naturaleza relacional.
RELATIONSHIP BETWEEN STRENGTH AND DEFORMATION CHARACTERISTICS OF HIGH-STRENGTH SELF-COMPACTING CON-CRETE
Authors: Bezgodov Igor , Kaprielov Simyon , Sheynfeld Andrey
Published: June 2022

he paper provides data on the strength and deformation characteristics of heavy self-compacting concrete of classes B30-B100 with a cubic compressive strength of 36.5-114.8 MPa. It has been established that the values of the concrete prism compressive strength (36.2-104.2 MPa) are 42-64% higher than the normalized values given in the building code of the Russian Federation SP 63.13330.2018. The values of the static modulus of elasticity for high-strength concretes of classes B80-B100 are 44.1-48.1 GPa and exceed by 5-12% the values given in SP 63.13330.2018. The ultimate compressive strains of concrete of classes B30-B100 are in the range from 261×10-5 to 326×10-5 and exceed the value of 200×10-5 given in SP 63.13330.2018. Complete deformation diagrams of self-compacting concretes of classes B30-B100 have been constructed. The nonlinearity of these ones decreases with increasing concrete strength. The descending branch of the σ-ε diagram is observed only for concrete of a class below B55 with a total relative compres-sive strain of 403.3 × 10-5 under a loading level of 0.85Rb. Concrete of classes B55-B100 has no descending branch. Previously established dependencies are refined for the analytical description of strains and stresses at any stages of loading structures.
COMPRESSIVE CYLINDER STRENGTH AND DEFORMABILITY OF EXPANDED CLAY FIBER-REINFORCED CONCRETE WITH POLYPROPYLENE FIBER
Authors: Maskalkova Yuliya , Rzhevutskaya Valeryia
Published: June 2022

This article presents the experimental studies results of the reinforcement effect with polypropylene fiber (0.5 %, 1 %, and 1.5 %) on the strength (compressive cylinder strength) and deformation (compressive strain) characteristics for expanded clay concrete. The most effective fiber percentage is the content of 1.5 % by weight of the cement mass, based on obtained experimental results. An increase in the compressive cylinder strength (up to 13 %), a significant increase in the value of ultimate compressive strain in concrete (corresponding to the peak stress) of the stress-strain diagram (up to 50 %), and the plastic failure of expanded clay fiber-reinforced concrete is noted.
TEMPERATURE DEFORMATIONS OF PVC WINDOW PROFILES WITH REINFORCEMENT
Authors: Aksenov Ivan , Konstantinov Aleksandr
Published: June 2022

Modern window structures made of PVC profiles can experience significant temperature deformation during both winter and summer operation. This effect is not considered in the current engineering methods of PVC windows calculation, which causes a number of problems in their operation (freezing and blowing through the windows, the failure of fittings, etc.). The use of laboratory methods of testing windows for temperature loads is limited due to their labor intensity and the high cost of testing equipment. We propose to develop an engineering method for calculating the mechanical operation of PVC windows under the action of temperature loads, which can be used at an early stage of design. One of the stages of its creation is a theoretical description of the temperature deformation of a PVC window profile when it works together mechanically with a reinforcing core. The article describes the nature of the forces transmitted by the PVC profile on the core during thermal bending (the case of temperature deformation at negative outside temperatures is considered). It was proposed to decompose these forces into two components: longitudinal, caused by different values of temperature shrinkage of PVC profile and reinforcing core, and transverse, caused by thermal bending of PVC profile. Mathematical models have been developed to calculate both force components and temperature deformation of the profile at different numbers and spacing of attachment points. A physical model has been proposed for implementation in the numerical calculation program, which allows a more accurate description of the temperature deformation of a long profile. Calculation of the test problem according to the proposed methodology and by means of full-fledged three-dimensional finite-element modeling in the COMSOL Multiphysics program was performed. A comparison of the results showed a discrepancy of less than 10%. It was found that the key influence on the deformations of PVC window profiles with a reinforcing core will have characteristics of the outermost joints "PVC profile – reinforcing core", because the greatest forces arise in them under the action of temperature loads.
Determinants of Using Ride-Hailing Service: Evidence from Malaysia
Authors: Lim Ee Shiang , Fernandez Jacqueline Liza
Published: June 2022

With the entrance of Uber into the land transportation industry, ride-hailing service has gained popularity and changed the way people travel in urban areas in Malaysia. Despite the growing popularity of this new mode of cab service, studies about factors influencing consumers’ choice to use ride-hailing service are limited in developing countries. This study used primary data collected via a survey in Penang, Malaysia. This study aims to examine the factors affecting consumers’ decision to utilise ride-hailing service. The novelty of this study is the adoption of a Heckman probit selection model to account for the possibility of sample selection bias and the introduction of an important explanatory variable - consumers’ comparative satisfaction with the attributes of ride-hailing and traditional taxi service that affect consumers’ choice of cab service. The results show age, gender, education, marital status, income, cost considerations and vehicle ownership significantly determine the probability of using cab service. Consumers’ choice between ride-hailing and traditional taxi service is affected by gender and their comparative rating of both services in terms of waiting time and the disposition of drivers. This suggests the necessity for cab service providers to improve their service in order to remain competitive in the industry.
Foreign Assets Management and Capital Expenditure: Firm-Level Evidence from 45 Emerging Market Economies
Authors: Zehri Chokri
Published: June 2022

This paper investigates the effects of foreign assets management (FAM), led by policymakers in emerging market economies, on companies’ capital expenditure with international financial shocks (IFS). Using company-level data from 45 emerging market economies from 2005 to 2020, we employed a multiplicative regression setup for Tobin’s Q ratio capital expenditure framework. First, our findings show that FAM positively affects capital expenditure; this impact is reinforced with stronger detrimental IFS. Second, the capacity to access foreign funding supports FAM policy, and more financially constrained companies are less responsive to FAM. Third, capital controls and macroprudential policies support FAM – they create a protective policy mix in the IFS context. The statistical significance of FAM’s impact on companies’ capital expenditure has an economic implication and is pertinent to the global economy. This study recommends coordinating macro-management policies to isolate companies’ capital expenditure from IFS effectively.
More than Tea - Environmental Decay, Administrative Isolation and the Struggle for Identity in Darjeeling
Authors: Yu Ren , Wang Qianyi , Cheong Kee Cheok
Published: June 2022

The victim of both geographical, historical and administrative isolation, Darjeeling owed its growth to tea cultivation in the hills by migrants from neighbouring Nepal collectively called Gorkhas. Their contributions notwithstanding, they felt discriminated by West Bengal’s residents to whose state they were administratively attached. Poverty and poor working conditions, with no voice in the tea estates, and poorly maintained infrastructure that brought frequent landslides have fuelled demands for “Gorkhaland”, a homeland separate from West Bengal, where the distinctiveness of their identity and their role as Indian citizens would be fully recognised. It did not help that the Darjeeling district had been administratively detached from the political mainstream. Periodic agitations against the state government have weakened local institutions, disrupted the local economy impacting adversely tea production and tourism on which the local economy and the Gorkhas depend. The West Bengal government had partly recognised Gorkha demands by establishing the Darjeeling Gorkha Hill Council and the Gorkhaland Territorial Administration (GTA) each vested with limited autonomy. But disagreements on autonomy have left the Gorkhaland issue unresolved. In the meantime, Darjeeling continues to experience gradual decay, absent adequate support from the West Bengal government and from Darjeeling’s local government, including the GTA itself.