bluuebunny/crossref_metadata_2025 huggingface dataset:
Review of modern melasma treatment methods
Authors: Bychkova N. Yu. , Lemytskaya V. E. , Sokolovskaya Yu. A. , Zhukova O. V. , Kasikhina E. I.
Published: September 2024

Melasma is a common, difficult-to-treat pigmented skin disease characterized by a recurrent course. The article provides an overview of the etiology, pathogenesis and principles of melasma therapy. The multifactorial nature of the disease was noted, including genetic predisposition, exposure to ultraviolet and visible light, and hormonal factors. It is known that visible light, especially high-energy visible light with a wavelength of 400–500 nm (High Energy Visible Light, HEV rays, blue light), and long-wavelength UVA rays (370–400 nm) exacerbate the course of melasma. The importance of an integrated approach to treatment, including the elimination of trigger factors, pathogenetic therapy and mandatory photoprotection using modern broad-spectrum sunscreens, is emphasized. Special attention is paid to the need to inform patients about the chronic nature of melasma and the importance of prolonged therapy. The article considers a multi-level treatment regimen based on the use of topical drugs and peels as first-line therapy, with careful and balanced use of hardware methods at subsequent stages. The key principles of hyperpigmentation therapy are described, namely, inhibition of melanogenesis, reduction of melanosome transport and acceleration of melanin elimination processes. Given example of modern depigmenting topical treatment containing Thiamidol (Beiersdorf AG patent), which contribute to the improvement of mMASI (Modified Melasma Area and Severity Index) after 2 weeks of usage, and justified treatment with Thiamidol for monoand combination therapy of melasma. The proposed three-stage treatment regimen, adapted to the severity of the disease, makes it possible to optimize therapeutic tactics taking into account the individual characteristics of the patient.
INCONSTITUCIONALIDADE E ILEGALIDADE DA INCLUSÃO DE MERCADORIAS, BENS OU SERVIÇOS NO REGIME DE ICMS-ST POR ATOS INFRALEGAIS
Authors: Melo Igor Frizera de , Mendonça Marcelo Otávio de Albuquerque B. , Felicio Raphael Maleque
Published: September 2024

Segundo o art. 6º, da LC nº 87/1996, a lei estadual poderá atribuir a contribuinte do ICMS ou a depositário a qualquer título a responsabilidade pelo seu pagamento, hipótese em que assumirá a condição de substituto tributário. Acontece que, em atenção ao princípio da tipicidade fechada, previsto no art. 150, I, da CRFB/88 e nos arts. 3º e 97, do CTN, somente lei formal, elaborada pelo Poder Legislativo, pode definir os sujeitos de alcance da referida norma, sendo inconstitucional a delegação dessa competência ao Chefe do Poder Executivo Estadual.
Wastewater remediation using advanced oxidation processes (AOPs)
Authors: Shrivastava Preeti R. , Mategaonkar Meenal
Published: September 2024

Addressing the escalating global water demands, due to rapid population growth, especially hydrogen peroxide-based treatments, offer promising avenues for efficient water treatments while minimizing environmental impact. In Mumbai, India, where water demands are intensifying, this study explores the application of hydrogen peroxide as an eco-friendly and highly reactive oxidizing agent for wastewater treatment. The research aims to replace conventional aeration methods with AOPs to reduce treatment time and space. The study demonstrates the effectiveness of hydrogen peroxide in significantly improving water quality, as the water quality index shows a 93% reduction in the post-treatment of contaminants. Additionally, the National Sanitation Foundation Water Quality Index (NSFWQI) indicates improvements from 100 to 200%. These findings underscore the potential of AOPs, particularly hydrogen peroxide, to offer sustainable alternatives for domestic wastewater treatments. By leveraging AOPs, municipalities can enhance water treatment efficiency, supporting efforts to meet escalating water demands sustainably amid population growth.
A Molecular Dynamic Simulation, Structural Analysis, and Ex Vivo Insights into the P-glycoprotein Mediated Interactions of Dietary Polyphenols with Cyclin-dependent Kinase Inhibitors: A Potential Strategy to Counteract Drug Efflux
Authors: Patil Prajakta Harish , Desai Mrunal Pradeep , Anand Vullendula Sai Krishna , Ray Rajdeep , Shenoy G. Gautham , Dengale Swapnil Jayant , Bhat Krishnamurthy , Channabasavaiah Jagadish Puralae
Published: September 2024

Introduction:

P-glycoprotein, an ATP-dependent efflux transporter, plays a
crucial role in eliminating cellular toxins and affects the intracellular concentration and
bioavailability of CDK 4/6 inhibitors. Moreover, dietary flavonoids are natural bio-enhancers
that can effectively inhibit the efflux function of these transporters. Therefore,
this study aimed to assess the impact of dietary polyphenols on the inhibition of P-glycoprotein
and the subsequent efflux of CDK inhibitors palbociclib and ribociclib.

Methods:

A molecular docking approach was implemented to evaluate the binding interaction
characteristics of CDK4/6 inhibitors in the presence of dietary polyphenols at the
ATP binding site. Furthermore, the stability of the complexes was evaluated in two conformations
of P-glycoprotein, followed by an ex vivo everted gut sac experiment.

Results:

The findings demonstrated that the binding of curcumin and quercetin with
high affinity (-51.63 and -47.16 Kcal/mol) to ATP binding sites of P-glycoprotein-palbociclib
and ribociclib inward conformation complexes resulted in good stability of complex
and minimal fluctuation throughout the course of the simulation. It was evident
from the everted gut sac ex vivo study that the presence of 100 μM of curcumin resulted
in an increase of 1.77 and 4.20-fold in the intestinal transit of palbociclib and ribociclib,
respectively.

Conclusion:

The study emphasizes the significance of curcumin and quercetin as inhibitors
of P-glycoprotein, demonstrating their potential to decrease the efflux of palbociclib
and ribociclib, consequently contributing to their bioavailability enhancement.
Anticancer Potential of Pineapple and its Bioactive Compound Bromelain
Authors: Kumar Davinder , Suchitra  , Mundlia Jyoti , Yadav Shiv Kumar , Yadav Deepika , Aggarwal Navidha , Chopra Hitesh , Kumar Virender , Kamal Mohammad Amjad
Published: September 2024

Various ailments have been treated with pineapple (Ananas comosus (L.) Merr.) throughout medicinal
history. Pineapple and its bioactive compound bromelain possess health-promoting benefits. Detailed information
on the chemotherapeutic activities of pineapple and its bioactive compound bromelain is provided
in this review, which analyses the current literature regarding their therapeutic potential in cancer. Research
on disease models in cell cultures is the focus of much of the existing research. Several studies have demonstrated
the benefits of pineapple extract and bromelain for in vitro and in vivo cancer models. Preliminary animal
model results show promise, but they must be translated into the clinical setting. Research on these compounds
represents a promising future direction and may be well-tolerated.
Extracorporeal Shock Wave and Melatonin Alleviate Joint Capsule Fibrosis after Knee Trauma in Rats by Regulating Autophagy
Authors: Mao Jing , Zhang Jin-Niu , Zhang Quan-Bing , Zhu De-Ting , Li Xue-Ming , Xiao Han , Kan Xiu-Li , Zhang Run , Zhou Yun
Published: September 2024

Background:

Joint contracture is a common clinical problem affecting joint
function. Capsule fibrosis plays a pivotal role in the progression of Joint contracture.
Previous studies have reported that autophagy plays a regulatory role in visceral
fibrosis.

Objective:

This study aimed to investigate whether extracorporeal shock wave
therapy (ESWT) and melatonin alleviate joint capsule fibrosis in rats with extended
knee joint contracture by regulating autophagy.

Methods:

A rat traumatic knee joint extension contracture model was made. Then, the
rats were treated with ESWT, melatonin, ESWT + melatonin, or ESWT + melatonin +
mTOR agonist for 4 weeks. The range of motion (ROM) of the knee joints was
measured. Joint capsules were collected and observed for pathological changes by
H&E and Masson staining. LC3B protein expression was evaluated by immunofluorescence
staining. TGF-β1, MMP-1, Col-Ⅰ, Col-Ⅲ, LC3, ATG7, Beclin1, p-AMPK,
p-mTOR and p-ULK1 protein expressions were measured by Western blot assay

Results:

The intervention groups had significantly improved ROM of knee joint (P <
0.05), significantly improved pathological changes on HE and Masson staining,
significantly decreased protein expressions of TGF-β1, MMP-1, Col-Ⅰ, Col-Ⅲ and pmTOR
(P < 0.05), and significantly increased protein expressions of LC3B, LC3II/LC3I
ratio, ATG7, Beclin1, p-AMPK, and p-ULK1 (P < 0.05). Among these groups, the
effects demonstrated by the ESWT + melatonin group were the best. With the mTOR
agonist supplement, the therapeutic effects of extracorporeal shock waves and
melatonin were significantly reduced.

Conclusion:

ESWT plus melatonin alleviated knee joint capsule fibrosis in rats by
regulating autophagy.
Detection Of CCR5 Delta-32 Mutation Using High-Resolution Melting Curve Analysis: Challenges and Facts
Authors: Kiani Seyed Jalal , Donyavi Tahereh , Bokharaei-Salim Farah
Published: September 2024

Introduction:

The C-C chemokine receptor type 5 (CCR5) is a major co-receptor for
human immunodeficiency virus (HIV). Some individuals carry the CCR5 delta-32 genetic polymorphism.
People with homozygous CCR5 delta-32 gene are nearly completely resistant to
HIV-1 infection. High-resolution melting curve (HRM) analysis is a post-PCR technique utilized
for identifying genetic variations in a quick, affordable, and closed-tube assay. The objective of
this study was to develop an HRM assay for easy detection of delta-32 mutations.

Materials and Methods:

DNA was extracted from peripheral blood mononuclear cells. HRM was
performed to detect delta-32 mutation. The study investigated the impact of various factors, including
annealing temperature, template concentration, touchdown PCR, additives, amplicon size,
and program settings, on HRM Tm differentiation.

Results:

It was expected that there would be a 4°C Tm difference between amplicons with and
without delta-32 mutation, but the test showed a difference of only 2.3°C. In attempts to identify
heterozygote delta-32 variants, a Tm difference of only 0.4°C could be achieved. Various modifications
were applied, such as adjusting the template concentration, using touchdown PCR, and adding
DMSO and glycerol. However, none of these changes helped to differentiate the Tm effectively,
especially in delta-32 heterozygote samples.

Conclusion:

The HRM test identified four samples with heterozygote mutations in each HIV-infected
(8.89%) and control (5.72%) groups. More importantly, this study showed that identifying
the delta-32 mutation of the CCR5 gene using HRM assay is not as straightforward as previously
suggested in some literature, and it requires special setup conditions.

conclusion:

The HRM test identified four samples with heterozygote mutations in each HIV-infected (8.89%) and control (5.72%) groups. More importantly, this study showed that identifying the delta-32 mutation of the CCR5 gene using HRM assay is not as straightforward as previously suggested in some literature, and it requires special setup conditions.
Investigating the Effect of COVID-19 on Pregnancy-Induced Hypertension (HTN): A Case-Control Study
Authors: Fathabad Mohadeseh Nazari , Raesi Rasoul , Hushmandi Kiavash , Kargar Shiva , Safipour Haniyeh , Daneshi Salman
Published: September 2024

Background:

Suppression of the body's immune system can cause high blood pressure.
Also, many people with COVID-19 have underlying diseases, including high blood pressure.

Aim:

This study was conducted to investigate the effect of COVID-19 infection on blood pressure
caused by pregnancy in women referred to Kashani Hospital in Jiroft City.

Methods:

This study was a case-control study with a census sampling method on 266 pregnant women
referring to Kashani Hospital in Jiroft City in 2021-2022. Pregnant women were divided into
two control groups (pregnant women without COVID-19) and intervention (pregnant women with
COVID-19). SPSS software version 22 was analyzed.

Results:

266 pregnant women participating in the study were divided into two equal control (133)
and intervention (133) groups. The average age of pregnant women was 29 ± 6.8 years. The average
systolic and diastolic blood pressure in the intervention group was 112.6 and 70, and in the
control group, it was 107.8 and 66.6, which was not statistically significant (P_Value>0.05). Also,
the results showed that there was a difference between home blood pressure during pregnancy and
there is a statistically significant relationship between the age of pregnant women (P_Value<
0.05).. while there is no significant statistical relationship between gestational age and body
mass index (P_Value>0.05).

Conclusion:

According to the results of this study, COVID-19 affects blood pressure caused by
pregnancy, and gestational age is an important factor in the prevalence of high blood pressure in
women with COVID-19.
Recent Development of Zolmitriptan Formulation in Migraine Therapy: Production, Metabolism and Pharmaceutical Aspects
Authors: Bano Farha , Aba Alkhayl Faris F. , Rashid Mohammad , Alqethami Mohammed Ghanim , Alsufyani Mohammed Omair , Alhothali Khadijah Oudah R. , Hakme Mohammed Japer Mohammed , Al-Jarallah Abdulrahman Mohammed , Dewangan Rikeshwer Prasad , Husain Asif
Published: September 2024

The triptans class of pharmaceuticals, which was created to treat acute migraine, is
made up of indole-containing drugs that bind to a subset (1B/1D) of 5-hydroxytryptamine
receptors and are agonists of serotonin receptors. At the moment, naratriptan, eletriptan,
zolmitriptan, rizatriptan, almotriptan, and frovatriptan are the seven types of triptans available on
the market. Among these are the FDA-approved triptans, Zolmitriptan and Sumatriptan, which
are selective serotonin (5-hydroxytryptamine) agonists. Zolmitriptan, a synthetic tryptamine
derivative and a well-known member of the triptan family, is available as an orally disintegrating
tablet, nasal spray, and tablet. There are melt formulations of rizatriptan and zolmitriptan
available on the market that are easier to use and absorb, comparable to regular pills. Recently,
the FDA approved zolmitriptan, a medication with tolerability comparable to sumatriptan.
Whereas zolmitriptan is only available as an oral melt or tablet, sumatriptan is available as a
nasal spray, oral preparation, or self-injectable kit. The only known antimigraine drugs that were
widely utilized before the triptan period were ergotamine and dihydroergotamine. However,
zolmitriptan binds to plasma proteins only 25% of the time because of significant first-pass
degradation. Researchers have looked into fresh ideas for solving this issue and innovations to
overcome its pharmacokinetic difficulties. This article emphasizes the role of zolmitriptan in the
treatment of migraines, highlighting its pharmacological properties, production, metabolism, and
structural features.
Synthesis, Computational Studies, and Biological Evaluation of Sulpha-methoxazole-Based Schiff Bases as Antimicrobial Agents
Authors: Kumar Sushil , Haider Mohd
Published: September 2024

Background:

Sulphamethoxazole-based Schiff-base compounds display poten-tial antibacterial and antifungal activity. Sulphamethoxazole is considered to be a versatile pharmacophore that can be utilized for designing and developing numerous bioactive lead compounds. In this work, some new sulphamethoxazole-based Schiff base compounds were synthesized, which are expected to possess antimicrobial activity, making them potentially useful for treating microbial infections.

Objective:

Concerning issues of drug resistance in presently available drugs, this study aimed to synthesize new sulphamethoxazole-based Schiff bases and evaluate their antimi-crobial activity.

Methods:

New sulphamethoxazole-based Schiff bases were synthesized by condensing sul-phamethoxazole with various acetophenones in methanol in the presence of glacial acetic acid. The synthesized compounds were characterized using various techniques, such as TLC, melting point, IR, NMR, and mass analysis. The computational properties of the com-pounds were also assessed using online software programs, and the similarity of the target compounds was also calculated as compared to sulphamethoxazole and clotrimazole. The antimicrobial activity of the target compounds was tested against Bacillus subtilis (Gram-positive), Escherichia coli (Gram-negative), and Candida albicans.

Results:

The target compounds (3a-f) were successfully synthesized and characterized by spectroscopic and analytical methods. The results of computational properties, similarity, and antimicrobial activity against B. subtilis, E. coli, and C. albicans of new sulphamethox-azole-based Schiff bases showed significant antimicrobial potential.

result:

The results of computational properties, similarity and antimicrobial activity against B. subtilis, E. coli and C. albicans of new sulphamethoxazole based Schiff bases showed significant antimicrobial potential.

Conclusion:

The synthesized new Schiff bases, particularly compound 3c, exhibited prom-ising antimicrobial activity and good physicochemical properties as compared to standard drugs, indicating their potential for further development as antimicrobial agents.
Crack Growth Behavior in Metal-elastomer Bonding Interface under Cyclic Deformation
Authors: Chen Xuming , Zonoz Ray , Salem Hamid
Published: September 2024

Introduction:

Metal-elastomer adhesion becomes increasingly important for elastomer
parts comprising metal components, such as packer elements for Blowout Preventers (BOP),
completion packers, metal encapsulated seals, and stator/rotors. As the bonding between metal
and elastomer deteriorates under cyclic deformation, cracks can appear on the adhesion interface
and reduce the function of the parts.

Methods:

Thus, the fatigue performance or crack growth rate of the metal-elastomer adhesion
affects the service life of the whole elastomer part. In this study, the metal-elastomer bonded
parts were fabricated and evaluated under cyclic shear and peel deformation at both room temperature
and high temperature.

Results:

The crack growth rates (dc/dN) on the metal-elastomer interface were measured based
on the strain energy release rate (Gc) for different elastomers with both excellent and poor adhesion,
and the API lifetime of BOP packers were therefore estimated.

Conclusion:

The results indicated that the crack growth rates in the adhesion interface can be
correlated with the API lifetime of BOP packers, and the elastomer with a low crack growth rate
will have a better fatigue life for the BOP application.
РОЛЬ НЕЙРОМЕДІАТОРІВ У ФОРМУВАННІ КОГНІТИВНОЇ ФУНКЦІЇ ПРИ ЕКСПЕРИМЕНТАЛЬНОМУ ГІПЕРТИРЕОЗІ В РАННЬОМУ ОНТОГЕНЕЗІ
Authors: Демченко Олена , Козлова Юлія , Попова Тетяна
Published: September 2024

Актуальність. Одним із провідних індикаторів дії на організм стресорних факторів є рівень тиреоїдних гормонів. Відома роль тиреоїдних гормонів у формуванні вищої адаптаційної реакції ЦНС надає дослідженням механізму формування когнітивної функції при гіпертиреоїдизмі за умов емоційного навантаження суттєвого значення, зокрема у ранньому онтогенезі, коли потреба в даних гормонах зростає.
Мета роботи – розкрити нейромедіаторний механізм формування когнітивної функції при гіпертиреозі та емоційному навантаженні в ранньому онтогенезі у щурів для подальшого пошуку можливостей корекції порушень психосимптомокомплексу пацієнтів молодшого віку.
Матеріали та методи. Експерименти були проведені на 32 білих безпородних щурах віком 30-40 діб, вагою 40-60 г, які були розподілені на дві групи: «експериментальний гіпертиреоз» та «контроль». Гіпертиреоз створювали шляхом введення з їжею L-тироксину. В подальшому тварини кожної з двох груп піддавалися хронічному емоційному навантаженню – перебуванню у відкритому водному просторі 3 хвилини при температурі 21°C (5 сеансів по 1 щодобово). Поведінку щурів досліджували у водному лабіринті Морріса та піднесеному хрестоподібному лабіринті. Хроматографічно визначали вміст нейромедіаторних сполук (гліцин, ГАМК, глутамат) і серотоніну в тканинах кори головного мозку і гіпокампу. Математична обробка включала розрахунки середніх арифметичних значень, стандартних відхилень, критерій Стьюдента та кореляційний аналіз Пірсона.
Результати. За умов експериментального гіпертиреозу у ювенільних щурів спостерігалося порушення поведінки, яке супроводжувалося зменшенням вмісту серотоніну в гіпокампі на 32% та підвищенням рівня ГАМК в корі великих півкуль на 39%. Хронічне емоційне навантаження на фоні експериментального гіпертиреозу викликало у ювенільних щурів формування депресивноподібного стану та порушення просторового навчання, що супроводжувалось підвищенням вмісту ГАМК в корі на 40% та зменшенням рівня гліцину в корі на 23% і в гіпокампі на 40% відносно тварин без модельної патології щитоподібної залози.
Висновки. За умов експериментального гіпертиреозу у ювенільних щурів спостерігалося порушення поведінки, яке супроводжувалося зменшенням вмісту серотоніну в гіпокампі та підвищенням рівня ГАМК в корі великих півкуль. Дослідження спонтанної поведінки ювенільних щурів з експериментальним гіпертиреозом та хронічним емоційним навантаженням виявило значне посилення орієнтовно-дослідницької активності, тривожності та емоційності, що свідчить про розвиток депресивноподібного стану та, як наслідок, погіршення просторової пам’яті. Дані порушення поведінки та когнітивний дефіцит супроводжувалися дисбалансом нейромедіаторів, а саме, збільшенням вмісту ГАМК в корі та зменшенням гліцину в корі і гіпокампі експериментальних тварин.
PERCEPÇÕES DE SAÚDE NA FORMAÇÃO INICIAL EM EDUCAÇÃO FÍSICA
Authors: Fernandes Laura Viana , De Araújo Allyson Carvalho
Published: September 2024

Tendo em vista a histórica associação da saúde unicamente com aspectos biológicos e a persistência dessa perspectiva na escola e no meio acadêmico, o estudo teve como objetivo investigar como os estudantes de graduação de licenciatura em Educação Física da Universidade Federal do Rio Grande Norte, de diferentes momentos formativos, entendem a saúde. A pesquisa assume caráter exploratório de abordagem qualitativa, e se desenvolveu por meio de um questionário semiestruturado que buscou entender a compreensão de saúde baseada em elementos que se relacionam com esta percepção, como: o conceito, a atividade física, a Educação Física escolar e os aspectos de qualidade de vida. Verificou-se a predominância da visão biológica de saúde sobre ingressantes e sobre alguns concluintes, demonstrando que a formação inicial em Educação Física não tem conseguido ampliar a noção de saúde dos novos professores.
Predicting Adherence to Computer-Based Cognitive Training Programs Among Older Adults: Study of Domain Adaptation and Deep Learning
Authors: Singh Ankita , Chakraborty Shayok , He Zhe , Pang Yuanying , Zhang Shenghao , Subedi Ronast , Lustria Mia Liza , Charness Neil , Boot Walter
Published: September 2024

Background

Cognitive impairment and dementia pose a significant challenge to the aging population, impacting the well-being, quality of life, and autonomy of affected individuals. As the population ages, this will place enormous strain on health care and economic systems. While computerized cognitive training programs have demonstrated some promise in addressing cognitive decline, adherence to these interventions can be challenging.

Objective

The objective of this study is to improve the accuracy of predicting adherence lapses to ultimately develop tailored adherence support systems to promote engagement with cognitive training among older adults.

Methods

Data from 2 previously conducted cognitive training intervention studies were used to forecast adherence levels among older participants. Deep convolutional neural networks were used to leverage their feature learning capabilities and predict adherence patterns based on past behavior. Domain adaptation (DA) was used to address the challenge of limited training data for each participant, by using data from other participants with similar playing patterns. Time series data were converted into image format using Gramian angular fields, to facilitate clustering of participants during DA. To the best of our knowledge, this is the first effort to use DA techniques to predict older adults’ daily adherence to cognitive training programs.

Results

Our results demonstrated the promise and potential of deep neural networks and DA for predicting adherence lapses. In all 3 studies, using 2 independent datasets, DA consistently produced the best accuracy values.

Conclusions

Our findings highlight that deep learning and DA techniques can aid in the development of adherence support systems for computerized cognitive training, as well as for other interventions aimed at improving health, cognition, and well-being. These techniques can improve engagement and maximize the benefits of such interventions, ultimately enhancing the quality of life of individuals at risk for cognitive impairments. This research informs the development of more effective interventions, benefiting individuals and society by improving conditions associated with aging.
An Electronic Medical Record–Based Prognostic Model for Inpatient Falls: Development and Internal-External Cross-Validation
Authors: Parsons Rex , Blythe Robin , Cramb Susanna , Abdel-Hafez Ahmad , McPhail Steven
Published: September 2024

Background

Effective fall prevention interventions in hospitals require appropriate allocation of resources early in admission. To address this, fall risk prediction tools and models have been developed with the aim to provide fall prevention strategies to patients at high risk. However, fall risk assessment tools have typically been inaccurate for prediction, ineffective in prevention, and time-consuming to complete. Accurate, dynamic, individualized estimates of fall risk for admitted patients using routinely recorded data may assist in prioritizing fall prevention efforts.

Objective

The objective of this study was to develop and validate an accurate and dynamic prognostic model for inpatient falls among a cohort of patients using routinely recorded electronic medical record data.

Methods

We used routinely recorded data from 5 Australian hospitals to develop and internally-externally validate a prediction model for inpatient falls using a Cox proportional hazards model with time-varying covariates. The study cohort included patients admitted during 2018-2021 to any ward, with no age restriction. Predictors used in the model included admission-related administrative data, length of stay, and number of previous falls during the admission (updated every 12 hours up to 14 days after admission). Model calibration was assessed using Poisson regression and discrimination using the area under the time-dependent receiver operating characteristic curve.

Results

There were 1,107,556 inpatient admissions, 6004 falls, and 5341 unique fallers. The area under the time-dependent receiver operating characteristic curve was 0.899 (95% CI 0.88-0.91) at 24 hours after admission and declined throughout admission (eg, 0.765, 95% CI 0.75-0.78 on the seventh day after admission). Site-dependent overestimation and underestimation of risk was observed on the calibration plots.

Conclusions

Using a large dataset from multiple hospitals and robust methods to model development and validation, we developed a prognostic model for inpatient falls. It had high discrimination, suggesting the model has the potential for operationalization in clinical decision support for prioritizing inpatients for fall prevention. Performance was site dependent, and model recalibration may lead to improved performance.
The effectiveness of psychotherapies in reducing further suicide attempts: a systematic review with meta-analysis of randomized controlled trials
Authors: Santos Luciana Almeida , Teodoro Maycoln Leôni Martins , De Oliveira Fellipe Couto
Published: September 2024

There is little evidence on the effectiveness of psychotherapeutic interventions in reducing new suicide attempts. This article aims to evaluate the effectiveness of psychotherapeutic interventions in reducing suicide attempts among patients with a history of previous attempts. We selected 17 articles from four databases: PubMed, Cochrane, APA PsycInfo and LILACS, in 2023. Six studies showed statistical differences that favored psychotherapeutic intervention at some point during the follow-up period. These psychotherapies addressed: problem-solving, hope induction, skills training. When comparing psychotherapy with usual care, a meta-analysis revealed an odds ratio of 0.41 (95 % CI, 0.17-0.99, p = .05) in the analysis up to 12 months of follow-up, and an odds ratio of 0.48 (95 % CI, 0.30-0.78, p < .001) after 12 months of follow-up. The results indicate the efficacy of these interventions in reducing additional suicide attempts, but they should be analyzed with caution, given the heterogeneity of the sample, treatments, and comparators. This review supports the development of prevention strategies indicated for patients who have attempted suicide.
Short-term dietary supplementation of β-glucan and chitosan modulates the immune response in freshwater prawn, Macrobrachium rosenbergii (De Man, 1879)
Authors:   ICAR-Central Institute of Freshwater Aquaculture, Bhubaneswar–751 002, India, Sahoo S. , Badhe M.R. ,   ICAR-Central Institute of Freshwater Aquaculture, Bhubaneswar–751 002, India, Paul A. ,   ICAR-Central Institute of Freshwater Aquaculture, Bhubaneswar–751 002, India, Sahoo P.K. ,   ICAR-Central Institute of Freshwater Aquaculture, Bhubaneswar–751 002, India, Das K.C. ,   ICAR-Central Institute of Freshwater Aquaculture, Bhubaneswar–751 002, India, Panda D. ,   ICAR-Central Institute of Freshwater Aquaculture, Bhubaneswar–751 002, India, Pillai B.R. ,   ICAR-Central Institute of Freshwater Aquaculture, Bhubaneswar–751 002, India, Baliarsingh S. ,   P.G. Department of Biosciences and Biotechnology, Fakir Mohan University, Balasore–756 089, India, Patnaik B.B. ,   P.G. Department of Biosciences and Biotechnology, Fakir Mohan University, Balasore–756 089, India, Mohanty J. ,   ICAR-Central Institute of Freshwater Aquaculture, Bhubaneswar–751 002, India
Published: September 2024

Aim: The present study evaluates the immunomodulatory potentials of β-glucan and chitosan administered orally for 15 days to the freshwater prawn, Macrobrachium rosenbergii juveniles. Methodology: Two diets were formulated supplementing 1.5 g kg-1 and 20 g kg-1 of β-glucan (diet G) and chitosan (diet C), respectively, with a control diet (diet B). The prawns were fed twice daily at 5% biomass. At the end of the feeding trials, mRNA expression profiles of immune-related genes lipopolysaccharide- and β-1,3-glucan binding protein (LGBP) and chitinase 3 were analyzed in qPCR. Corresponding LGBP protein and chitinases/CBP (chitinase 1, chitinase 1C and obstructor E, a chitin-binding protein) protein levels were also estimated by ELISA. Results: Supplementation of the immunostimulants (diets G and C) significantly enhanced the mRNA expression of both LGBP and chitinase 3 in the hepatopancreas. The protein expression of LGBP and chitinases/CBP was also significantly increased in the serum and hepatopancreas samples of both treatment groups. Interpretation: The short-term supplementation of β-glucan and chitosan in diets demonstrated beneficial effects in M. rosenbergii by enhancing the expression of important immune molecules like LGBP and chitinases, indicating their potential applications during the period of biotic stress. Key words: β-glucan, Chitinase, Hepatopancreas, Immunostimulants, LGBP, Macrobrachium rosenbergii
CoC 25–An early maturing high-yielding and red rot-resistant sugarcane variety suitable for the East Coast Zone of India
Authors:   Agricultural College a0nd Research Institute, Tamil Nadu Agricultural University, Thiruvannamalai - 606 756, India, Ganapathy S. , Latha R. ,   ICAR, Krishi Vigyan Kendra, Tamil Nadu Agricultural University, Kanyakumari - 629 901, India, Purushothaman R.S. ,   Sugarcane Research Station, Tamil Nadu Agricultural University, Cuddalore - 607 001, India, Ravichandran V. ,   Regional Research Station, Tamil Nadu Agricultural University, Vridhachalam - 606 001, India, Jayakumar J. ,   ICAR-Krishi Vigyan Kendra, Tamil Nadu Agricultural University, Thiruvarur-614 404, India, Karunakaran V. ,   ICAR, Krishi Vigyan Kendra, Vridhachalam - 606 001, India, Appunu C. ,   ICAR, Sugarcane Breeding Institute, Coimbatore- 641 007, India
Published: September 2024

Aim: To develop early duration high-yielding sugarcane variety coupled with resistance or tolerant to major disease (red rot) and insect pests (borer complex). Methodology: CoC 25 was developed from two parents (Co 85002 and HR 83-144) and evaluated in station trials, state multi-location trials (five locations) and zonal varietal trials of AICRP (S) trials (IVT, AVT-I, AVT-II and AVT ratoon in five locations). Simultaneously, this clone was screened for major pest and diseases. Results: Based on the superiority performance of CoC 25 in cane yield (21.50% higher) and sugar yield (22.72% higher), it was observed in AICRP trials over the national check variety CoC 01061. Cane yield superiority was 12.75% compared to check variety observed in state multi-location trials. The CoC 25 was found moderately resistant (3.6%) to red rot disease and less susceptible to early shoot borer (9.42%) and inter-node borers. Interpretation: The results of this study revealed that CoC 25 is superior in terms of cane yield, CCS yield and resistance to red rot disease and it is less susceptible to borers. It was released by SVRC and notified for commercial cultivation in Tamil Nadu and Puducherry. Key words: Cane yield, CCS yield, Red rot resistance, Sugarcane
Biofilm mediated antibiotic resistant oral bacteria among Parkinson's patients
Authors:   Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore -641 114, India, Joel J. , Xavier P. ,   Department of Mathematics, Karunya Institute of Technology and Sciences, Coimbatore -641 114, India, Pillai J.S. ,   Department of Medical Laboratory Science, Komar University of Science and Technology, Sulaimaniyah, Kurddistan, 46001, Iraq, Sujitha T.S. ,   Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore -641 114, India, Iyer A. ,   Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore -641 114, India, Sree S. ,   Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore -641 114, India, Murugan S. ,   Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore -641 114, India
Published: September 2024

Aim: The aim of this study was to examine the oral microbe biofilm and antibiotic resistance in individuals with Parkinson's disease compared to those without the condition. Methodology: In this study, the oral bacteria of older patients with Parkinson's disease and those without the condition were examined for antibiotic resistance and biofilm formation. In this study, the microbiologists examined oral samples collected from 33 individual, out of which 18 sufferred from Parkinson's disease while the remaining 15 individuals were normal. This case involved the use of the Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) technology to identify six different species. Results: The analysis of oral samples showed the presence of six isolates viz. Staphylococcus epidermis, S. auricularis, S. simiae, Panebacillus thiaminolyticus, P. aeruginosa and Bacillus cereus. Out of these, P. thiaminolyticus was absent in the control group. The incidence of oral microorganisms was somewhat higher in Parkinson's disease patients than control individuals, however, there was no discernible variation in the oral bacterial strains found in the two research groups. The isolates underwent further analysis following Congo Red Agar and Tissue Culture Plate methods and showed positive result for biofilm formation. Each isolate found in the Parkinson's disease groups were found resistant to at least five antibiotics used. Interpretation: The ability to produce biofilm was present in approximately 83.3% of the isolates from the Parkinson's disease group and 80% of those from the control group. This study provides a deeper understanding of the relationship between biofilm-producing, antibiotic-resistant oral bacteria and Parkinson's disease, and also address the need for effective management of oral hygiene in Parkinson’s patients. Key words: Antibiotic resistance, Biofilm, Oral microbiota, Oral health, Parkinson’s disease
Comunicação pela luz: a construção de significados na promenade da catedral de Brasília
Authors:   , Holtz Luiz Gustavo dos Santos
Published: September 2024

O presente estudo insere-se na interface entre Comunicação e Arquitetura: o tratamento da arquitetura como linguagem, produtora de significados, justifica essa aproximação. O objeto de estudo em foco nesse diálogo é o potencial significativo da luz em obras arquitetônicas, e o objeto empírico é a Catedral de Brasília, obra do arquiteto brasileiro Oscar Neimayer, vista como signo. A questão norteadora assim se faz: como se dão os efeitos da luz na experiência vivida por pessoas que percorrem a promenade ou no caminho que leva ao altar da Catedral de Brasília? O objetivo principal que se delineia é o de contribuir para a compreensão destes significados; os objetivos específicos consistem em apresentar a luz em diferentes âmbitos – filosofia, religião, arte, arquitetura –, explicitar conceitos da semiotica peirceana que vão ancorar o tratamento da arquitetura e da luz como signos e linguagens; descrever e explicitar interpretantes gerados pela promenade da Catedral de Brasília. O percurso feito no local pelo caminhante/autor é o foco de interpretação nesta pesquisa; portanto, foi a partir do olhar do caminhante que se estabeleceu o método: o instrumental urdido por Santaella, sustentado pela semiótica de Charles S. Peirce. Centrado nos três modos de se apreender os fenômenos requisitados a um intérprete, esse instrumental institui três tipos de olhar: contemplativo, observacional e interpretativo para desenredar os significados da luz. Contudo, para efeito de ilustrar os passos dessa experiência prática, as fotografias registradas no trajeto serão utilizadas. Valemo-nos de teóricos que fundamentam a arquitetura, como Muller, Montaner, Oliveira e Frade; de historiadores sobre os significados da luz, como Almeida, Borsa, Dias e Fontoura, além de Santaella, Drigo e Souza para tratarmos a semiótica peirceana. Pensamos assim, contribuir com conhecimentos vindos da Comunicação, sobretudo os fundados na semiótica peirceana, para a compreensão da concepção da luz como elemento fundamental da arquitetura. Essa relação fortalece a interface Arquitetura e Comunicação através da semiótica.
Mídias digitais e cultura caipira: um estudo nas festas de São Luiz do Paraitinga
Authors:   , Schwab Matheus
Published: September 2024

Esta pesquisa tem como tema a relação entre cultura popular e as mídias digitais, guiada pelo questionamento: de que forma a cultura caipira apropria-se das mídias digitais? Como objeto de estudo, focou-se na relação entre as mídias digitais, principalmente os smartphones, e as festas realizadas na cidade de São Luiz do Paraitinga, no interior de São Paulo. Trata-se de uma cidade festiva e reconhecida como um reduto caipira. Assim, o objetivo principal deste estudo é identificar e compreender os sentidos presentes no uso das mídias digitais pelos caipiras presentes nas festas populares. Para isso, os objetivos específicos consistem em: evidenciar o caráter dinâmico da Cultura Caipira; identificar quais manifestações da Cultura Caipira podem ser encontradas em São Luiz do Paraitinga; identificar situações em que as mídias digitais se relacionam com a cultura caipira durante as festas populares de São Luiz do Paraitinga e de que forma elas produzem novos sentidos comunicacionais. O referencial teórico foi composto por: Néstor García Canclini e o conceito de Hibridação Cultural; Luiz Beltrão e a teoria da Folkcomunicação; Antônio Candido e seu estudo nas comunidades caipiras e Roberto DaMatta e seus conceitos em torno dos rituais. Após a realização de uma revisão bibliográfica, foi realizada uma pesquisa etnográfica contemplando oito festas e duas apresentações artísticas entre os meses de maio, junho, julho e agosto de 2022. Foram identificadas uma série de situações e exemplos em que as mídias digitais estiveram presentes durante as festas caipiras. Concluiu-se que há um atravessamento das mídias digitais sobre as festas. Isto incide na necessidade dos envolvidos com as festas realizarem uma série de adaptações em suas práticas sociais. Para isso, práticas distintas são recombinadas e é nesta etapa que ocorrem as apropriações. A recombinação e as apropriações geram novas práticas e estruturas que coexistem com as antigas. Por fim, esta operação tem como consequência a ampliação, tanto dos meios digitais, quanto das festas.
Analysis of Acceptance of Simulated Practices in Respiratory Therapy Students
Authors: Vélez García Claudia Patricia , Castillo-Daza Carlos A. , Casallas Hernández Nathalya
Published: September 2024

Resumen: Las prácticas clínicas simuladas son una herramienta innovadora diseñada para mejorar la colaboración interdisciplinaria en educación para la salud, así como la comunicación asertiva y la toma de decisiones basadas en el pensamiento crítico, el razonamiento clínico y la ética. Estas prácticas ofrecen a los estudiantes controlados; Escenarios del mundo real dirigidos por instructores. Este estudio tuvo como objetivo evaluar la aceptación de prácticas simuladas entre estudiantes de Terapia Respiratoria en una universidad de Bogotá, Colombia. Se realizó un estudio cuantitativo transversal con 243 estudiantes que completaron un cuestionario del Modelo de Aceptación de Tecnología (TAM) a través de Google Forms. Los datos se recogieron de marzo a mayo de 2024, siguiendo las directrices éticas. Resultados: El cuestionario mostró una alta fiabilidad interna, con un Alfa de Cronbach de 0,97. Las puntuaciones medias superiores a 4 en todas las categorías de TAM indicaron fuertes interrelaciones.: El TAM fue eficaz para evaluar las condiciones de aprendizaje de los estudiantes e identificar estrategias para mejorar el uso de los laboratorios de simulación tanto por parte de los estudiantes como de los instructores.
The Adoption of E-ticketing Apps on Intercity Buses: A Transdisciplinary Approach
Authors: Hakim Muhammad Malik , Adhy Satriyo , Ashari Yeva Fadhilah , Siswanah Emy
Published: September 2024

The acceleration and development of toll road infrastructure have caused a rapid increase in bus intercity travel. Bus entrepreneurs further offset the number of passengers by increasing the number of fleets and bus departure hours. Furthermore, to facilitate the management and booking of travel tickets, bus companies use e-ticketing apps. This research investigates the factors that affect the adoption of e-ticketing apps with a transdisciplinary approach. Data was collected by providing questionnaires to respondents using random sampling techniques, with valid data from 243 respondents. Furthermore, data processing and analysis are carried out using SmartPLS 3 software. Based on hypothesis testing, the factors constructed in the model were perceived ease of use, subjective norm, information quality, online review, and price-saving orientation, which positively and significantly affect the intention to use e-ticketing apps.
Neopulvinaria innumerabilis (Rathvon, 1854), a new species of Coccidae in Serbia
Authors: Dervisevic Marina , Graora Draga
Published: September 2024

In 2016, the species Neopulvinaria innumerabilis (Rathvon, 1854), belonging
to the scale insect family Coccidae, was for the first time found in Serbia,
in the location Radmilovac on Cornus sanguinea L. It reproduces by
gamogenesis, develops one generation annually, and overwinters as a
fertilized female on the trunk or branches of its host plant. During this
research, the species was detected on five host plants at six locations in
Serbia. It feeds by sucking sap from leaves, young shoots and branches of
infested plants, causing desiccation of leaves and individual twigs. Four
species of its natural enemies were collected and reared from colonies of N.
innumerabilis. Two species of parasitoid wasps, Coccophagus lycimnia
(Walker) (Aphelinidae) and Metaphycus hageni Daane and Caltagirone
(Encyrtidae), were found, while the ladybird Exochomus quadripustulatus L.
(Coccinellidae) and the fly Leucopomyia silesiaca (Egger) (Chamaemyiidae)
were identified as predators. The most abundant entomophagous species was L.
silesiaca.
Operative treatment of calcified thoracic disc herniation: A case report on natural fusion method following spinal canal decompression
Authors: Jelaca Bojan , Lasica Nebojsa , Golubovic Jagos , Pajicic Filip , Bijelovic Milorad , Djilvesi Djula
Published: September 2024

Introduction. The literature describes several ways to approach the thoracic spinal segment, but there are still many dilemmas regarding what is best to do after a complete discectomy, regardless of the surgical approach chosen. The incidence of postoperative kyphosis is higher if a posterior surgical approach to the spine is performed, and there are no clearly defined indications for the application of intervertebral fusion (IF) after an anterior approach. The aim of the paper was to highlight the low morbidity of the transthoracic multi-disciplinary approach, as well as a potential solution for a good, natural IF of the adjacent vertebrae without expanding and prolonging the duration of the surgical procedure itself. Case report. A 44-year-old woman presented with severe anterior compressive myelopathy caused by a calcified thoracic disc herniation in the space between the T10-11 vertebrae. A minimally invasive, open, transthoracic approach was per-formed with decompression of the spinal canal at the specified level and IF was achieved with an autologous rib graft during the same procedure. A control examination of the thoracolumbar segment using the magnetic resonance imaging showed that there is no more compression of the spinal cord and also showed a good IF without an increase in the level of kyphosis. Conclusion. Significant thoracic disc herniation is a rare and challenging surgical lesion. The anterior mini-open transthoracic approach provides good exposure to the relevant structures and is considered minimally invasive. The benefits of subsequent IF after the transthoracic surgical approach should always be taken into account for each individual patient, thus minimalizing the postoperative morbidity.
The Need for an Interactive Cell Biology Textbook Based on Case Studies by Integrating QR Codes
Authors: Harlis  , Dara Mutiara Aswan
Published: September 2024

Cell Biology is a course whose material is abstract because it cannot be observed with the naked eye. The problem in learning Cell Biology is that no reference books can make abstract material more real to facilitate students' understanding. This research aims to analyze students' needs for Case Study-based interactive Cell Biology textbooks by integrating QR Codes. This research is quantitative and descriptive. The subjects in this research were Biology Education students. Data was obtained through interviews, observations, and questionnaires. Data were analyzed using quantitative descriptive methods. Based on data analysis, 67.6% of students stated that they could only imagine the structures and processes in cells, and 86.5% needed help understanding Cell Biology material. The results of the data analysis also show that all samples agreed to develop teaching materials that integrate QR codes connected to various videos or literature. Based on these results, an interactive cell biology textbook based on case studies needs to be created by further integrating QR codes.