bluuebunny/crossref_metadata_2025 huggingface dataset:
Die nachhaltige Zahnmedizin - Teil 1: Nachhaltigkeit im Umfeld von Zahnarztpraxen
Authors: Mahler Léon , Cetin Steven , Ramseier Christoph A.
Published: March 2024

Die Nachhaltigkeit in Zahnarztpraxen spielt eine immer grössere Rolle. Dabei haben externe und interne Faktoren Einfluss auf die Emissionen einer Praxis. Die externen Faktoren umfassen die Domänen Politik, Wissenschaft und Bildung. Es ist eminent, dass die Diskussion über den Umwelteinfluss im Gesundheitswesen in diesen drei Domänen Einzug findet, da sie den Grundstein für Verhaltensänderungen legt und somit den Weg für eine «grünere» Zukunft ebnet. Die internen Faktoren umfassen Praxisbetrieb, Lieferkette, Angestellte und Patienten. Insgesamt ist das Thema Nachhaltigkeit in der zahnmedizinischen Arbeitswelt kaum verbreitet. Dieser erste Artikel einer zweiteiligen Serie zeigt auf, wie die Nachhaltigkeit bei Zahnärztinnen und Zahnärzten in der Praxis und bei ihrer Arbeit unter dem Einfluss von vielen Umgebungsfaktoren steht, die in ihrer Gesamtheit das Zusammenspiel von Umwelt und Zahnmedizin beeinflussen können.
Der Low­Level­Laser in der Oralchirurgie und Stomatologie
Authors: Sekerci Esra , Kuster Irina , Schiefersteiner Mona
Published: March 2024

Der Low-Level-Laser (LLL) wurde erstmals 1960 beschrieben. Er hat einen biostimulierenden oder biomodulierenden Effekt auf das Gewebe. Zudem kann der LLL in der photo- dynamischen Therapie genutzt werden (Karu 1989). Durch die tiefe Leistung zwischen 60 und 300 mW kommt es nicht zu einem thermischen Effekt oder einer schneidenden Wirkung auf das Gewebe. Die Wellenlänge liegt mit 600–900 nm im roten oder nahen infraroten Bereich (Mettraux 2004).
Eine radioluzente Rarität: Primär intraossäres Mukoepidermoidkarzinom des posterioren Unterkiefers: vom röntgenologischen Zufallsbefund zur molekularpathologischen Diagnose
Authors: Schwerzmann Martina C. , Schönegg Daphne , Linden Julian , Rodewald Ann-Katrin , Gander Thomas , Lanzer Martin
Published: March 2024

Wir berichten von einem 64-jährigen Patienten mit Zufallsbefund einer unilokulären Radioluzenz in regio 48 im apikalen Röntgen. Im Biopsat (Zystostomie) fand sich der aussergewöhnliche Befund eines primär intraossären Mukoepider-moidkarzinoms; dies ist mit 2 bis 4% der ektopen Manifestationen dieser Entität eine Rarität. Molekularpathologische Untersuchungen mit spezifischem Panel (SalvGlandDx) und FISH erbrachten den diagnosesichernden Nachweis der CRTC1- MAML2-Fusion. Es erfolgte die Kastenresektion, prophylaktische Osteosynthese mittels patientenspezifischer Rekonstruktionsplatte, Neck Dissection und lokale Deckung mittels Bichat- Lappen gemäss interdisziplinärem Tumorboardentscheid. Bei tumorfreien Lymphknoten und R0-Resektion war keine adjuvante Therapie erforderlich. Klinische und bildgebende Nachsorge über nun 24 Monate zeigten keine Hinweise auf ein lokoregionäres Rezidiv. Die vorgestellte Kasuistik betont die zentrale Rolle der zahnärztlichen Privatpraxen in der Früherkennung oraler Mali- gnome. Diese sollten in der Differenzialdiagnostik zystischer Läsionen stets bedacht werden.
Gingivaepithesen: Vergessenes Hand­ werk oder Technik mit Zukunft dank CAD/CAM?
Authors: Hatz Christian R. , Bühler Elias , Schmidlin Patrick R.
Published: March 2024

Eine Patientin (Jg. 1973) wurde für eine systema­ tische Parodontitisbehandlung überwiesen. Nach abgeschlossener Hygienephase (Schritt 1 und 2) fand die erste Reevaluation nach drei Monaten statt. Dabei zeigte sich bereits eine ausgezeich­ nete Verbesserung der parodontalen Gesundheit mit lediglich wenigen lokalen Resttaschen. Aller­ dings war die Ästhetik der Oberkieferfront auf­ grund generalisierter, ausgeprägter Rezessionen stark kompromittiert. Auf Patientenwunsch wurde daher die Indikation zu einer mittelfristi­ gen Versorgung mit einer Gingivaepithese zur Kaschierung der Weichgewebsdefekte gestellt. Diese wurde nach konventioneller Polyäther­ abformung im Labor mittels CAD/CAM­Techno­ logie aus einem Hochleistungspolymer gefräst und manuell individualisiert.
Radiographies intraorales : étude de qualité
Authors: Freyche Sarah , Vazquez Lydia
Published: March 2024

Le collimateur rectangulaire permet de diminuer la dose d’irradiation absorbée par les patients. Cette étude contrôle la qualité des radiographies intraorales réalisées par des étudiants de la Clinique universitaire de médecine dentaire (Université de Genève, Suisse) en analysant l’impact de l’utilisation du collimateur rectangulaire sur les clichés. Huit étudiants ont réalisé des radiographies chez des patients adultes avec des plaques radiologiques numériques. 130 radiographies ont été récoltées et un score de qualité a été attribué à chaque image. La moitié des radiographies a été réalisée avec un collimateur rectangulaire. Les clichés réalisés avec collima- teur rectangulaire étaient de qualité excellente ou suffisante au diagnostic pour 95 % des radio- graphies rétro-coronaires et 100 % des radiographies rétro-alvéolaires. Cette étude de qualité montrant que des étudiants réalisent des radio- graphies intraorales de qualité avec un colli- mateur rectangulaire pourrait encourager des cliniciens à utiliser ce dispositif en tant que moyen de radioprotection dans leur pratique quotidienne.
Interzeptive Kieferorthopädie
Authors: Kubala René , Minoretti Roger
Published: March 2024

Zum Ziel einer kieferorthopädischen Behand- lung gehört nebst der Nivellierung der Zähne im ästhetisch relevanten Bereich auch das Erreichen einer stabilen Situation in parodontaler und ok- klusärer Hinsicht. Wünschbar ist es auch, eine Gebisssituation zu erreichen, die wenig zukünf- tige zahnärztliche Interventionen benötigt.
Minimalinvasive Versorgung von Erosionen zur Wiederherstellung von Gesundheit, Funktion und Ästhetik mit indirekten Restaurationen
Authors: Ioannidis Alexis , Fiscalini Lorenzo , Paqué Pune Nina , Patrizi Andrea
Published: March 2024

In diesem Artikel wird die Behandlung von Zahnhartsubstanzverlust aufgrund von Erosionen mit- tels indirekter Restaurationen aus Lithiumdisilikat-Keramik diskutiert. Minimalinvasive Ansätze werden empfohlen, bei denen die erodierten Zähne konservativ präpariert und mit minimalinvasi- ven Restaurationen versorgt werden. Lithiumdisilikat-Keramiken sind derzeit das Material der Wahl für diese Art von Behandlung, da sie maximalen okklusalen Kräften im posterioren Gebiet standhalten können. Der Restaurationsprozess sollte durch diagnostische Verfahren geleitet werden, die das klinische Therapieziel zu Beginn der Behandlung definieren. Eine adhäsive Zementierung mit dem richtigen Protokoll ist entscheidend für die volle mechanische Festigkeit der Restauration. Zum Behandlungsabschluss wird neben präventiven Massnahmen eine Schutz- schiene für die Nacht empfohlen, um die klinische Langzeitstabilität zu gewährleisten.
Die chirurgische Entfernung eines Torus palatinus
Authors: Schmidt Valérie , Valdec Silvio
Published: March 2024

Der Torus palatinus (TP) ist eine benigne Exostose im Bereich der Sutura palatina media. Er besteht hauptsächlich aus dichtem kortikalem und wenig trabekulärem Knochen sowie einer darüberliegenden, gering durchbluteten Mukosa. Neuere Erkenntnisse assoziieren das Auftreten von TP mit Bruxismus, Umweltfaktoren und genetischen Faktoren. Ein TP verursacht selten Symptome, somit ist eine Behandlung nur in ausgewählten Fällen notwendig. Chronische Traumata, kaufunktionelle Beeinträchtigung oder Kompromittierung der prothetischen Versorgung stellen die häufigsten Indikationen für die operative Entfernung dar.
Enregistrement du rapport maxillo-mandibulaire en prothèse amovible partielle métallique (PAPM)
Authors: Benyahia Hassnae , Abdelkoui Anissa , Yadfout Asmae , Merzouk Nadia , Berrada Salwa
Published: March 2024

L’enregistrement du rapport maxillo-mandibu- laire (RMM) est une étape primordiale et incon- tournable qui intervient à des stades différents du traitement lors des réhabilitations prothétiques. La dualité tissulaire, problématique majeure de la prothèse amovible partielle métallique (PAPM), notamment dans les édentements en extension et ceux de grande étendue, est responsable d’imprécisions occlusales aboutissant à des res- taurations mal ou non intégrées à l’appareil manducateur du patient. Pour effectuer cette étape, le praticien doit choisir le matériau, confectionner le support adéquat et adopter une technique fiable et reproductible adaptée à la si- tuation clinique et à l’étape prothétique. L’objectif de ce travail est de proposer une démarche simp- le et codifiée, qui garantit un enregistrement du rapport maxillo-mandibulaire fidèle, adapté aux particularités des structures d’appui et prenant en considération la séquence clinique pour une intégration occluso-fonctionnelle optimale de la future prothèse amovible partielle métallique.
A survey on systemic antibiotic prescription among dentists in Romandy
Authors: Loume Alexandre , Gardelis Panagiotis , Zekeridou Alkisti , Giannopoulou Catherine
Published: March 2024

Antimicrobial resistance (AMR) is a significant global health threat that arises from the excessive and incorrect use of antibiotics. As key players in the evolution of AMR, medical and dental practitioners are often questioned on their indications for antibiotic prescription during daily practice. The present survey aimed to evaluate self-reported practices regarding systemic antibiotic prescription among Swiss dentists in Romandy. An electronic questionnaire was sent to 331 dentists working in the French-speaking part of Switzerland and the responses were analyzed on a three-point Likert scale. The response rate was 28%. Results showed that the main indications for antibiotic use were abscesses with systemic symptoms (89%), cellulitis (81.5%), acute sinusitis (62%) and necrotizing periodontitis (52%). Surgical procedures most frequently combined with antibiotics were sinus floor elevation (59.8%) and implant placement (60.9%). Amoxicillin was the first-choice antibiotic, and clindamycin was mostly prescribed for patients with a penicillin allergy (87%). The majority of dentists recommended prophylaxis with 2g of amoxicillin, one hour before the procedure for patients with a high risk of endocarditis (82.6%), immunodeficiency / immunosuppression (50%), or joint replacement during the last year (47.8%). Most participants (76.1%) expressed the need for specific guidelines on the use of antibiotics in dentistry. The research findings suggested antibiotic prescriptions in dentistry could profit from stricter guidelines.
Accepted for publication: July 11, 2023
Published online: July 13, 2023
The multi-luting concept: a new approach to facilitate the adhesive luting of multiple indirect restorations
Authors: Gerdolle David , Browet Stephane , Gresnigt Marco
Published: March 2024

Bonded indirect restorations can be difficult to lute in an accurate position due to the lack of preparation geometry. Furthermore, while the use of a rubberdam has been proven to be the best technique for providing the most efficient conditions for adhesive luting, its use often requires the use of secondary clamps, which do not allow the operator to lute more than two prosthetic pieces at the same time. The multi-luting concept is a pragmatic approach that of- fers the possibility to deliver several, if not all restorations, to be bonded at the same time, thus ensuring their correct positioning.
A 3-year Retrospective Analysis of Dento-Alveolar Injuries at the University Children’s Hospital Zurich (2018-2020)
Authors: Schmid Claudio , Fongaufier Christelle , Hamza Blend , Hoehn Tobias , Staubli Georg , Stadlinger Bernd
Published: March 2024

Children and adolescents are vulnerable to dental trauma due to their active lifestyles, lack of coordination, and inexperience in recognizing potentially dangerous situations. Early recognition and proper management of dental trauma is crucial in order to minimize the risk of complications and ensure optimal outcomes. The aim of this study was to perform a retrospective analysis of all dento-alveolar injuries in children and adolescents who were treated at the University Children’s Hospital Zurich from 2018-2020 by the resident physicians of the Centre of Dental Medicine of the University of Zurich. All information concerning age and sex distribution, seasonal and weekly variations, as well as aetiology, types of trauma and co-affected structures in the head and neck area from 389 patients was analysed. For data extraction, a parameterised Excel list was created, enabling a continuous data collection. In the study, 65% of the patients were male and 35% female. The average patient age was 7 years and 4 months. The highest frequency of trauma occurred in mixed dentition (49%), followed by deciduous dentition (36%) and permanent dentition (15%). Most of the accidents occurred in the second quarter of the year, especially in the month of May slightly more injuries were reported. The most common injuries were increased tooth mobility (40%) and tooth fractures without pulp exposure (34%). Less frequent were tooth fractures with pulp exposure (12%), lateral dislocations (29%), avulsions (21%), intrusions (8%), extrusions (6%) and root fractures (4%). As in many studies the upper central incisors were most often affected. Main causes of dental trauma were falls, especially by bike (18%) or scooter (14%). Soft tissue injuries or fractures, in the area of the head and neck occurred in 59% and 10% of the cases simultaneously accompanied by dento-alveolar trauma.
Total rehabilitation in case of amelogenesis imperfecta
Authors: Bücheli-Kamber Rita , Meyer-Lückel Hendrik , Jaeggi Thomas
Published: March 2024

The aim of the treatment of this case was to restore the form, function and aesthetics of all teeth in a patient with amelogenesis imperfecta within the age limit of the disability insurance (IV). Single-tooth zirconia crowns were selected as the treatment of choice and cemented with a conventional glass ionomer cement. For the maintenance of the oral rehabilitation and the protection of the reconstructions a michigan splint was produced and instructed to be carried over night.
Fibromatous Epulis: A Clinical Case Report
Authors: Fatori Sandra , Burlaka Roksolana , Lübbers Heinz Theo , Zenklusen Reinhild , Filippi Andreas
Published: March 2024

A 35-year-old patient presented with a painless, broad-based exophytic lesion in the buccal interdental region between teeth 13 and 14. Despite oral hygiene efforts the lesion persisted for around one year. Radiology excluded bone involvement, and histopathology after excision confirmed a fibromatous epulis, which is characterized by collagen-rich connective tissue. There was no recurrence within one-year follow-up. Surgical removal proved to be efficient.
Impact of final rinse with saline or alcohol solution on root canal sealability
Authors: Vasudev Ballal Nidambur , Narkedamalli Rajkumar , Camilleri Josette , Kapralos Vasileios , Zehnder Matthias
Published: March 2024

Endodontic irrigation protocols are not only used to clean and disinfect the root canal system, but also to condition the canal wall dentine for subsequent root filling. In this study we tested whether a final irrigation step with saline solution or 80% ethanol improved root canal sealabilty by two popular sealers, an epoxy resin (AH Plus) and a hydraulic calcium silicate cement-based product (BioRoot RCS). Root canals in extracted single-rooted human teeth were instrumented and filled with a matched gutta-percha cone and sealer. During instrumentation and prior to root filling, sealer-specific irrigation protocols were applied. These involved a combined sodium hypochlorite/1-hydroxyethylidene-1,1-diphosphonic acid application, which was followed by irrigation with ethylenediaminetetraacetic acid (EDTA) for AH Plus. Protocols were followed by a 5-ml ultimate rinse with saline solution or 80% ethanol. No such final rinse was the control (N = 9). Canals were then dried with matched paper points. One week after root filling and storage of the teeth at 37°C in a humid environment, Rhodamine B was used to trace leakage. Two-way ANOVA revealed that the type of sealer had a significant (P < 0.05) impact on apical dye penetration while the final rinse did not (P > 0.05). AH Plus provided the slightly better seal (P < 0.05). Leakage occurred between the sealer and the dentin with AH Plus, and between the sealer-to-dentin as well as the sealer-to-gutta-percha interface with BioRoot RCS. In summary and under current conditions, there was no benefit from applying saline or ethanol as an ultimate rinsing solution prior to drying the canal with matched paper points.
Changes in periapical status of root canal-treated teeth after head and neck IMRT: a retrospective study
Authors: Steiner Sina R. , Saccardin Fabio , Connert Thomas , Filippi Andreas
Published: March 2024

The objective of this retrospective study was to analyze the effect of the intensity modulated radiotherapy (IMRT) of the head and neck region on root canal-treated teeth and their periapical changes due to radiation. Patients undergoing IMRT of the head and neck region were evaluated. Different types of teeth (molars, premolars, incisors and canines) were compared. Panoramic and dental radiographs were used to assess the periapical region of root canal-treated teeth using the periapical index (PAI) before and after radiotherapy (RT) and put in relation to the radiation dose per tooth. Further parameters (patient-, therapy- and tooth-related factors) were included in this study. One hundred and twenty-four root canal-treated teeth (maxilla and mandible) of 51 patients were observed. A radiolucency in the periapical region was seen in 34.7% of the samples before IMRT and an increasing number of 46% after IMRT (p-value 0.092). Clinical or radiological signs of osteoradionecrosis could not be determined. The only statistically significant difference was detected in regions irradiated with less than 40 Gy (p-value 0.045). In regions irradiated with higher doses (>40 Gy), comparable pathologies increased in non-significant numbers. A statistically significant increase of periapical pathologies was detected in premolars of the maxilla. The observations reported here suggest that a high radiation dose during IMRT has no significant consequences on root canal-treated teeth. To compare the success of endodontic treatment before versus after IMRT, further research needs to be done.
ANALYSIS OF LEGAL PROTECTION OF BANKING CUSTOMER DATA IN REVIEW OF LAW NUMBER 8 OF 1999 CONCERNING CONSUMER PROTECTION
Authors: Polontoh Herry , Silambi Sinta Suwarti
Published: March 2024

The protection of banking customer data is increasingly important along with the advancement of information technology and the adoption of electronic banking services by the public. Although Law No. 8/1999 on Consumer Protection (UUPK) already exists, it only regulates consumer protection in general and does not specifically regulate the protection of banking customer data. In practice, the implementation of the GCPL is also limited due to the lack of sanctions for customer data breaches. Therefore, this paper examines the international standard personal data regulation that refers to the General Data Protection Regulation (GDPR) to understand more about customer data protection. This paper aims to analyze the legal protection provided to banking customer data in the context of Law No. 8/1999 on Consumer Protection. By examining the provisions of the law, this paper attempts to evaluate the extent to which the existing regulations have been able to effectively protect banking customer data. The analysis shows that although Law No. 9/1999 provides a legal basis for consumer protection in general, the specific protection of banking customer data still needs to be strengthened through more specific regulations and more effective law enforcement mechanisms
ROLE OF TEMPE FROM WEST SUMATRA AS A SOURCE OF VITAMIN B12 AND ANTIOXIDANT CAPACITY
Authors: Rosalina Linda , Bernward Bisping , Sumaryati Syukur , Asmar Yulastri
Published: March 2024

Tempe is the most popular traditional fermented food in Indonesia that has high nutritional values such as high protein content high fatty acid content, vitamin B12, excellent digestibility, and good antioxidant content sources. Tempe also has low in anti-nutrition factors such as phytic acid, oligosaccharides. The purpose of this study is to compare traditional Tempe produced from West Sumatra, Indonesia, which is comparing the yellow and black soybeans, with a focus on antioxidant capacity. Six samples of Tempe were collected in Padang and Padang Panjang, Indonesia. Microorganism isolated from tempe samples were identified and the antioxidant capacity was determined using different antioxidant capacity assays, then Vitamin B12 determination in mocrobiological assay was perfomed. The result is included the mean of antioxidant of black soybeans = 0.008333 with a standard deviation of 0.0006429 and the mean of antioxidant of yellow soybeans = 0.008767 with a standard deviation of 0.0027465. In conclusion, it can be seen that the F count for antioxidants is 8647 with a probability of 0.042. Because of the probability value is < 0.05, then H0 is rejected or the two population variances are different (heterogeneous).
Analysis of Green Consumer Behavior on Purchasing Waste Recycling Products Reviewed from Environmental Knowledges, Recycle Behavior, and Government Regulations
Authors: Leonard Natassya Adelia Candradhita , Meilina Restin
Published: March 2024

Indonesia is the second largest producer of waste after China with an estimated 0.48-1.29 million metric tons per year. Based on data from the Environment, Hygiene and Landscaping Agency (DLHKP), as of 2022 the Klotok Final Management Site (TPA) receives as much as 140 tons of waste per day, the waste is included in organic waste and inorganic waste. Meanwhile, inefficient waste handling can cause water quality in an area to be very poor and contain toxic waste and garbage that is allowed to accumulate can cause flooding and endanger public health. One of the community organizations that cares about waste processing is the Melati Waste Bank in Kediri City. The Melati Waste Bank is productive in carrying out activities to reduce waste in Kediri City, this is evidenced by the process of sorting waste, processing sorted waste, then distribute the product into the society. Unfortunately the efforts are under the expectations of the management and volunteers of the Melati Waste Bank are due to lack of interest in purchasing waste recycling products. This research uses qualitative methods using triangulation techniques where research is carried out by interviews. So as to obtain the results that consumer behavior in purchasing waste recycling products is based on environmental knowledges, recycle behavior and government regulations related to restrictions on the use of single-use plastics.
COMPARISON OF SARS-CoV ANTIBODY TITER LEVELS AGAINST ABO BLOOD TYPE, AGE, AND GENDER IN CONVALESCENT PLASMA DONATIONS
Authors: Ariani Resti , Puspita Rina , Astuti Anna Kartika Yuli , Lestari Aulia Dewi , Dewi Andriani Setiawan , Open Maria Kurniati Manggina
Published: March 2024

An important requirement to become a convalescent plasma donor is a standardized SARS-CoV antibody titer. However, not all Covid-19 survivors pass the plasma donor selection due to low antibody titer. This research aims to determine the comparison of SARS-CoV antibody titer levels with blood type, age and gender of Covid-19 convalescent plasma donors at blood donation unit PMI Semarang City. This study is an analytical observational study with a cross sectional design, using 300 data on convalescent plasma donors. The sampling technique used was purposive sampling. Differences in SARS-CoV antibody titer levels based on blood type, age, and gender were tested using SPSS 25. Donors involved in this study were divided based on the conversion of convalescent plasma titer levels, namely 1:80 (37%), 1:160 (4%), 1:250 (10.3%) and 1:640 (48.7%). Based on blood type data, most convalescent plasma donors have blood type O (42%) with the highest titer levels in the 1:640 category (48.7%). The highest mean titer level was found in blood group B which was 382.09. The results of the Kruskal-Wallis test showed no significant difference in titer levels by blood group, p=0.622 (>0.05). In the parameter of donor age, SARS-CoV antibody titer levels also showed no significant difference in donor age, both adolescent, adult and elderly donors with a value of p=0.598 (p>0.05). In line with these results, the chi square test of differences in antibody titres based on gender also showed no significant difference, p value=0.127 (p>0.05). High and low antibody titres of convalescent plasma donors are not determined by blood type, age and gender of the donor.
ANALYSIS OF COMMUNITY PERCEPTIONS TOWARDS THE EXISTENCE OF SATRIA BUS MASS TRANSPORTATION IN KEDIRI CITY
Authors: Pertiwi Ananda Tria Budi , Widiyanto Wahyu
Published: March 2024

This research aims to determine public perceptions regarding free city transportation "Satria Bus" in Kediri City, as well as finding out the advantages and disadvantages of this city transportation. The method in this research is descriptive with a qualitative approach using observation, interview and documentation study techniques. The validity test used is source triangulation. From the research results, it is known that the public's perception of the Satria Bus is that they are greatly helped by the free facilities provided by the Kediri City government. Satria buses can reduce the number of traffic accidents and reduce people's use of private vehicles which has an impact on reducing congestion. The existence of free buses is very supportive, especially for people in Kediri City as a means of moving from one place to another to carry out activities. This shows that the Satria Bus is very useful for the people in Kediri City. So, the government takes better care of the maintenance of the Satria Bus.
THE EUROPEAN UNION’S LAWSUIT OVER THE 2020 PROHIBITION OF INDONESIAN RAW NICKEL ORE EXPORTS
Authors: Basri Muhammad Hasan , Ismiyatun
Published: March 2024

This research discusses the reasons behind the European Union's lawsuit against Indonesia regarding the policy to ban the export of raw nickel ore in 2020. The background of Indonesia's ban on the export of nickel ore is part of the national plan to develop the domestic industrial sector, including stainless steel production. Based on this policy, the European Union implemented a foreign policy to sue Indonesia at the WTO, considering it a violation of the provisions of the WTO trade agreement under Article XI:1 of the GATT 1994. The method used in this research is a qualitative descriptive research method employing Robert Ghilpin's theory, which describes foreign policy influenced by domestic industry interests and external influences.The European Union's background as a stainless steel producer makes nickel the most significant value addition for the EU in terms of employment, taxes, investments, and product utility. Nickel's utility for the EU, simultaneously serving as a benefit, lies in high-performance technological products that leverage its characteristics of high heat resistance and durability. The comparison of the income results of the EU industry, which significantly impacts the economy, has experienced a decline since the implementation of Indonesia's export ban policy. Consequently, the European Union filed the lawsuit due to economic interests in the EU's domestic industry, such as labor absorption and financial contributions to the state.
Combination of Grey Relational Analysis (GRA) and Simplified Pivot Pairwise Relative Criteria Importance Assessment (PIPRECIA-S) in Determining the Best Staff
Authors: Setiawansyah Setiawansyah , Sintaro Sanriomi , Saputra Very Hendra , Aldino Ahmad Ari
Published: March 2024

Problems in selecting the best staff often involve complex challenges such as difficulty finding candidates with good performance. The problems faced in the selection of the best are only based on the assessment of discipline and productivity of performance carried out by the staff, so the assessment process does not use aspects of criteria that are considered important in selecting the best staff.  This study aims to determine the best staff based on predetermined criteria and in determining the selection of the best staff using the Gray Relational Analysis (GRA) decision model while in determining the weight of criteria using the Simplified Pivot Pairwise Relative Criteria Importance Assessment (PIPRECIA-S) model so that the weight of the resulting criteria is not based on assumptions from decision makers. The results of the best staff assessment ranking using the Gray Relational Analysis method and the Simplified Pivot Pairwise Relative Criteria Importance Assessment weighting method obtained the results, namely for Rank 1 obtained by Denis Irawan with a final Gray Relational Analysis value of 0.243014. The results of data processing in the TRITAM Model test for the best staff selection application were adjusted to the conclusion of the overall results of the TRITAM Model criteria for technology acceptance, the results were good at 82.56%.
New onset of uveitis during infliximab treatment: A case report
Authors: Bouladi Mejda , Ben Othmen Amal , Miladi Saoussen , Kalou Merieme , Laater Ahmed , El Fekih Lamia
Published: March 2024

Introduction: Anti-tumor necrosis factor α (anti-TNF α) agents are an effective treatment for a variety of inflammatory and autoimmune diseases. In ophthalmology anti-TNF α began to emerge as a possible therapy for non-infectious uveitis, paradoxically their administration may result in the onset or recurrence of inflammatory eye disease such as uveitis.  We reported a case of new onset of bilateral anterior and intermediate uveitis in a patient with rheumatoid arthritis (RA) while being treated with infliximab and we performed a review of literature.
Observation : A 25-year-old female with RA under infliximab, presented with bilateral blurred vision. Anterior segment examination demonstrated retrodescmetic fine precipates, 1+ cells in the anterior chamber on both eyes. The fundus examination was difficult because of the vitritis. Fluorescein angiography demonstrated mild optic disc edema, and bilateral diffuse peripheral fern leaf cappilaritis. Optical coherence tomography showed severe cystoid macular edema bilaterally. The diagnosis of bilateral anterior and intermediate uveitis caused by infliximab was retained after exclusion of infectious and autoimmune aetiologies. She was treated with corticosteroid with good visual outcome.
Conclusion : In our case, new onset of uveitis may be considered as paradoxical effect of anti-TNF α therapy. Rheumatologists and ophthalmologists should be aware of this effect. Careful monitoring of patients under infliximab is necessary for appropriate diagnosis and early treatment.
Predictive Modeling for Student Success: A Quantitative Correlational Study of a Private University in Rural New Mexico
Authors:   ,   University of the Southwest, Lopez Brianna
Published: March 2024

The six-year university graduation rate for minority, first-generation, and low-income students is significantly lower than it is for non-minority students, students whose parents went to college, and students from high-income families. The problem addressed in this study was small private, faith-based institutions do not have a viable model for proactively identifying at-risk students and thereby increasing student success among underrepresented groups. The purpose of this correlational study was to develop a model to increase student success at a small private, faith-based institution in rural New Mexico. Research question one sought to analyze the relationship between student success and environmental and demographic variables among minority students, first-generation students, and low-income students. The second research question sought to determine the extent to which these environmental and demographic variables influence student success among minority students, first-generation students, and low-income students. Information pertaining to demographics, course success, and term success were collected from student records at the site and analyzed for relationships. Findings include differences among demographic variables but no statistically significant relationships to develop predictive models. Recommendations include providing faculty and staff with key variables that highlight student success and also reassessing the tools and resources provided to freshman, sophomore, and first-time college students. Implications for social change include equipping the institution with a foundation for increasing student success. The findings in this study will also serve as a stepping stone towards improving student success within the institution.
Analysis of Unfunction Fire Alarm Analysis on MT. Pangrango
Authors: Brahmana Dhea Haniel Gracella , Wiweko Albert , Siregar Muhammad Sapril
Published: March 2024

Ships are a very efficient and effective means of transportation. With today's increasingly advanced, modern, and demanding developments, ships are also designed to be able to meet every expected human need. This research method uses a qualitative research approach which is analyzed descriptively. The research results show that an effective fire alarm system has enormous significance in the context of the maritime environment; maintenance of the detector will reduce the failure of the detector to detect fire so that the optical system and electronic circuit in the detector can work optimally. To ensure that the fire alarm is always operational in the event of a fire, we regularly test the alarm using our testing equipment.
Interactive PAI Science Quiz to Increase Students' Competitive Power through Kodular Applications
Authors: Salsabila Unik Hanifah , Nashrul Mu'minin Nashrul , Zuhdi Mohammad Naufal , Maulana Ikhwan Tegar , Ginajar Muhammad
Published: March 2024

This research aims to increase student involvement in Islamic Religious Education (PAI) subjects by utilizing a mobile learning application equipped with an interactive quiz feature built using the Kodular platform. The basis of this research was inspired by the results of previous research which showed that the use of technology can be effective in increasing students' motivation and level of participation in the PAI learning process. In order to achieve this goal, this research adopts a research and development (R&D) approach to design and implement a PAI interactive quiz application that utilizes the Kodular platform. The application is aimed at junior high school (SMP) students. In the development stage, the research team designed and developed the PAI interactive quiz application using the Kodular platform which allows creating mobile applications visually without requiring complex programming. This application is equipped with an interactive quiz feature that supports PAI learning. The result of this research is a Kodular-based learning media application. In conclusion, the integration of mobile learning technology offers an interactive, flexible and interesting learning experience for students, which contributes to increasing student motivation and participation in PAI learning. This research contributes to the development of innovative and effective PAI teaching methods through the use of technology.
Management of hyperlipidaemia
Authors: Marais A D , Blom D J , Raal F J
Published: March 2024

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Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: a population-based cohort study in UK Biobank
Authors: Zhang Yuchen , Sun Yitang , Yu Qi , Song Suhang , Brenna J. Thomas , Shen Ye , Ye Kaixiong
Published: March 2024

Circulating omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) have been associated with various chronic diseases and mortality, but results are conflicting. Few studies examined the role of omega-6/omega-3 ratio in mortality.We investigated plasma omega-3 and omega-6 PUFAs and their ratio in relation to all-cause and cause-specific mortality in a large prospective cohort, the UK Biobank. Of 85,425 participants who had complete information on circulating PUFAs, 6,461 died during follow-up, including 2,794 from cancer and 1,668 from cardiovascular disease (CVD). Associations were estimated by multivariable Cox proportional hazards regression with adjustment for relevant risk factors.Risk for all three mortality outcomes increased as the ratio of omega-6/omega-3 PUFAs increased (all P
trend
< 0.05). Comparing the highest to the lowest quintiles, individuals had 26% (95% CI, 15-38%) higher total mortality, 14% (95% CI, 0-31%) higher cancer mortality, and 31% (95% CI, 10-55%) higher CVD mortality. Moreover, omega-3 and omega-6 PUFAs in plasma were all inversely associated with all-cause, cancer, and CVD mortality, with omega-3 showing stronger effects.Using a population-based cohort in UK Biobank, our study revealed a strong association between the ratio of circulating omega-6/omega-3 PUFAs and the risk of all-cause, cancer, and CVD mortality.
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release
Authors: Wu Zhenyong , Kusick Grant F. , Berns Manon M. M. , Raychaudhuri Sumana , Itoh Kie , Walter Alexander M. , Chapman Edwin R. , Watanabe Shigeki
Published: March 2024

Despite decades of intense study, the molecular basis of asynchronous neurotransmitter release remains enigmatic. Synaptotagmin (syt) 7 and Doc2 have both been proposed as Ca
2+
sensors that trigger this mode of exocytosis, but conflicting findings have led to controversy. Here, we demonstrate that at excitatory mouse hippocampal synapses, Doc2α is the major Ca
2+
sensor for asynchronous release, while syt7 supports this process through activity-dependent docking of synaptic vesicles. In synapses lacking Doc2α, asynchronous release after single action potentials is strongly reduced, while deleting syt7 has no effect. However, in the absence of syt7, docked vesicles cannot be replenished on millisecond timescales. Consequently, both synchronous and asynchronous release depress from the second pulse onward during repetitive activity. By contrast, synapses lacking Doc2α have normal activity-dependent docking, but continue to exhibit decreased asynchronous release after multiple stimuli. Moreover, disruption of both Ca
2+
sensors is non-additive. These findings result in a new model whereby syt7 drives activity-dependent docking, thus providing synaptic vesicles for synchronous (syt1) and asynchronous (Doc2 and other unidentified sensors) release during ongoing transmission.
Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration
Authors: Lu Yu-Ming , Yan Shan , Ti Shih-Chieh , Zheng Chaogu
Published: March 2024

Tubulin posttranslational modifications (PTMs) modulate the dynamic properties of microtubules and their interactions with other proteins. However, the effects of tubulin PTMs were often revealed indirectly through the deletion of modifying enzymes or the overexpression of tubulin mutants. In this study, we directly edited the endogenous tubulin loci to install PTM-mimicking or -disabling mutations and studied their effects on microtubule stability, neurite outgrowth, axonal regeneration, cargo transport, and sensory functions in the touch receptor neurons of Caenorhabditis elegans. We found that the status of β-tubulin S172 phosphorylation and K252 acetylation strongly affected microtubule dynamics, neurite growth, and regeneration, whereas α-tubulin K40 acetylation had little influence. Polyglutamylation and detyrosination in the tubulin C-terminal tail had more subtle effects on microtubule stability likely by modulating the interaction with kinesin-13. Overall, our study systematically assessed and compared several tubulin PTMs for their impacts on neuronal differentiation and regeneration and established an in vivo platform to test the function of tubulin PTMs in neurons.
Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration
Authors: Lu Yu-Ming , Yan Shan , Ti Shih-Chieh , Zheng Chaogu
Published: March 2024

Tubulin posttranslational modifications (PTMs) modulate the dynamic properties of microtubules and their interactions with other proteins. However, the effects of tubulin PTMs were often revealed indirectly through the deletion of modifying enzymes or the overexpression of tubulin mutants. In this study, we directly edited the endogenous tubulin loci to install PTM-mimicking or-disabling mutations and studied their effects on microtubule stability, neurite outgrowth, axonal regeneration, cargo transport, and sensory functions in the touch receptor neurons of
Caenorhabditis elegans
. We found that the status of β-tubulin S172 phosphorylation and K252 acetylation strongly affected microtubule dynamics, neurite growth, and regeneration, whereas α-tubulin K40 acetylation had little influence. Polyglutamylation and detyrosination in the tubulin C-terminal tail had more subtle effects on microtubule stability likely by modulating the interaction with kinesin-13. Overall, our study systematically assessed and compared several tubulin PTMs for their impacts on neuronal differentiation and regeneration and established an
in vivo
platform to test the function of tubulin PTMs in neurons.
Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway
Authors: Chen Jianwen , Zhao Bao , Dong Hong , Li Tianliang , Cheng Xiang , Gong Wang , Wang Jing , Zhang Junran , Xin Gang , Yu Yanbao , Lei Yu L , Black Jennifer D , Li Zihai , Wen Haitao
Published: March 2024

The O-GlcNAc transferase (OGT) is an essential enzyme that mediates protein O-GlcNAcylation, a unique form of posttranslational modification of many nuclear and cytosolic proteins. Recent studies observed increased OGT and O-GlcNAcylation levels in a broad range of human cancer tissues compared to adjacent normal tissues, indicating a universal effect of OGT in promoting tumorigenesis. Here, we show that OGT is essential for tumor growth in immunocompetent mice by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pathway. We found that deletion of OGT (Ogt−/−) caused a marked reduction in tumor growth in both syngeneic mice tumor models and a genetic mice colorectal cancer (CRC) model induced by mutation of the Apc gene (Apcmin). Pharmacological inhibition or genetic deletion of OGT induced a robust genomic instability (GIN), leading to cGAS-dependent production of the type I interferon (IFN-I) and IFN-stimulated genes (ISGs). As a result, deletion of Cgas or Sting from Ogt−/− cancer cells restored tumor growth, and this correlated with impaired CD8+ T-cell-mediated antitumor immunity. Mechanistically, we found that OGT-dependent cleavage of host cell factor C1 (HCF-1) is required for the avoidance of GIN and IFN-I production in tumors. In summary, our results identify OGT-mediated genomic stability and activate cGAS-STING pathway as an important tumor-cell-intrinsic mechanism to repress antitumor immunity.
Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway
Authors: Chen Jianwen , Zhao Bao , Li Tianliang , Dong Hong , Cheng Xiang , Gong Wang , Wang Jing , Zhang Junran , Xin Gang , Yu Yanbao , Lei Yu L. , Black Jennifer D. , Li Zihai , Wen Haitao
Published: March 2024

The
O
-GlcNAc transferase (OGT) is an essential enzyme that mediates protein
O
-GlcNAcylation, a unique form of posttranslational modification of many nuclear and cytosolic proteins. Recent studies observed increased OGT and
O
-GlcNAcylation levels in a broad range of human cancer tissues compared to adjacent normal tissues, indicating a universal effect of OGT in promoting tumorigenesis. Here, we show that OGT is essential for tumor growth in immunocompetent hosts by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pathway. We found that deletion of OGT (

Ogt
−/−

) caused a marked reduction in tumor growth in both syngeneic tumor models and a genetic colorectal cancer (CRC) model induced by mutation of the
Apc
gene (

Apc
min

). Pharmacological inhibition or genetic deletion of OGT induced a robust genomic instability (GIN), leading to cGAS-dependent production of the type I interferon (IFN-I) and IFN-stimulated genes (ISGs). As a result, deletion of
Cgas
or
Sting
from

Ogt
−/−

cancer cells restored tumor growth, and this correlated with impaired CD8
+
T cell-mediated antitumor immunity. Mechanistically, we found that OGT-dependent cleavage of host cell factor C1 (HCF-1) is required for the avoidance of GIN and IFN-I production in tumors. In summary, our results identify OGT-mediated genomic stability and activate cGAS-STING pathway as an important tumor cell-intrinsic mechanism to repress antitumor immunity.
Senescent cells inhibit muscle differentiation via the lipid- SASP 15d-PGJ2 mediated modification and control of HRas
Authors: Pundlik Swarang Sachin , Sahoo Snehasudha Subhadarshini , Barik Alok , Venkateshvaran Ashwin , Jaysingh Mahapatra Anshuman , Math Raviswamy G H , Ramanathan Arvind
Published: March 2024

Senescent cells which are characterized by multiple features such as increased expression of SA β-gal and cell cycle inhibitors such as p21 or p16, accumulate with tissue damage and dysregulate tissue homeostasis. In the context of skeletal muscle, it is known that agents used for chemotherapy such as doxorubicin cause buildup of senescent cells, leading to the inhibition of tissue regeneration. Senescent cells influence neighboring cells via numerous secreted factors which form the senescence-associated secreted phenotype (SASP). Lipids are emerging as a key component of SASP that can control tissue homeostasis. Arachidonic acid-derived lipids have been shown to accumulate within senescent cells, specifically 15d-PGJ
2
, which is an electrophilic lipid produced by the non-enzymatic dehydration of the prostaglandin PGD
2
. In this study, we show that 15d-PGJ
2
is also released by Doxorubicin-induced senescent cells as a SASP factor. Treatment of skeletal muscle myoblasts with the conditioned medium from these senescent cells inhibits myoblast fusion during differentiation. Inhibition of L-PTGDS, the enzyme that synthesizes PGD
2
, diminishes the release of 15d-PGJ
2
by senescent cells and restores muscle differentiation. We further show that this lipid post-translationally modifies Cys184 of HRas in skeletal muscle cells, causing a reduction in the localization of HRas to the Golgi, increased HRas binding to RAF RBD, and activation of cellular MAPK-Erk signaling (but not the Akt signaling). Mutating C184 of HRas prevents the ability of 15d-PGJ
2
to inhibit the differentiation of muscle cells and control the activity of HRas. This work shows that 15d-PGJ
2
released from senescent cells could be targeted to restore muscle homeostasis after chemotherapy.