bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of castration on physiological responses to exertional heat stroke in mice
Authors: Garcia Christian K. , Robinson Gerard P. , Gambino Bryce J. , Rua Michael T. , Laitano Orlando , Clanton Thomas L.
Published: October 2022

Introduction

The capability of male mice to exercise in hot environments without succumbing to exertional heat stroke (EHS) is markedly blunted compared to females. Epidemiological evidence in humans and other mammals also suggests some degree of greater vulnerability to heat stroke in males compared to females. The origins of these differences are unknown, but testosterone has previously been shown to induce faster elevations in core temperature during acute, passive heat exposure. In this study, we tested the hypothesis that loss of testosterone and related sex hormones through castration would improve the performance and heat tolerance of male mice during EHS exposure.

Methods

Twenty-four male mice were randomly divided into 3 groups, untreated EHS mice (SHAM-EHS), castrated EHS mice (CAS+EHS) and naïve exercise controls (NAIVE). Exercise performance and physiological responses in the heat were monitored during EHS and early recovery. Two weeks later, blood and tissues were collected and analyzed for biomarkers of cardiac damage and testosterone.

Results

Core temperature in CAS+EHS rose faster to 39.5°C in the early stages of the EHS trial (P<0.0001). However, both EHS groups ran similar distances, exhibited similar peak core temperatures and achieved similar exercise times in the heat, prior to symptom limitation (unconsciousness). CAS+EHS mice had ~10.5% lower body mass at the time of EHS, but this provided no apparent advantage in performance. There was no evidence of myocardial damage in any group, and testosterone levels were undetectable in CAS+EHS after gonadectomy.

Conclusions

The results of these experiments exclude the hypothesis that reduced performance of male mice during EHS trials is due to the effects of male sex hormones or intact gonads. However, the results are consistent with a role of male sex hormones or intact gonads in suppressing the early and rapid rise in core temperature during the early stages of exercise in the heat.
A balancing act–finding one´s way to health and well-being: A qualitative analysis of interviews with Swedish university students on lifestyle and behavior change
Authors: Åsberg Katarina , Eldh Ann Catrine , Löf Marie , Bendtsen Marcus
Published: October 2022

Introduction

Unhealthy lifestyle behaviors such as unhealthy diets, low physical activity levels, smoking, and harmful alcohol consumption are common in student populations, which constitute a large group of young adults. As unhealthy lifestyle behaviors are associated with future disease and premature mortality, most commonly from cardiovascular disease and cancers, it is from a public health perspective important to understand such behaviors in young adult populations. The objective of this study was to investigate university students’ experiences of health, health-related behaviors, and the barriers and facilitators for behavior change in terms of health promotion in everyday life.

Materials and methods

This qualitative study was conducted at a middle-sized university in Sweden. Students represented different faculties and were recruited via non-probability convenience sampling using means such as the snowball technique and social media. The 21 interviews with 24 students, individually or in groups, were transcribed verbatim prior to a qualitative analysis inspired by phenomenological hermeneutics.

Results

Our interviews showed that university student life is associated with new health-related challenges, for example study-related stress and procrastination implies a lack of energy to engage in healthy routines such as physical activity, and a limited budget affects food choices. While adapting to a new context, students explore personal strategies such as taking on changes in manageable steps, seeking social support, and avoiding disturbances to maintaining health and quality of life.

Conclusions

Experiences of health while becoming and being a university student can be described as a transition–a balancing act of walking a slack line–during which students seek to manage a healthy balance. In the past, interventions have to some extent been designed to address university students’ behaviors; however, our study aids an understanding of their needs. Future interventions should highlight the transitions they are experiencing and the challenges of student life.
Dual specificity phosphatase 7 drives the formation of cardiac mesoderm in mouse embryonic stem cells
Authors: Sladeček Stanislava , Radaszkiewicz Katarzyna Anna , Bőhmová Martina , Gybeľ Tomáš , Radaszkiewicz Tomasz Witold , Pacherník Jiří
Published: October 2022

Dual specificity phosphatase 7 (DUSP7) is a protein belonging to a broad group of phosphatases that can dephosphorylate phosphoserine/phosphothreonine as well as phosphotyrosine residues within the same substrate. DUSP7 has been linked to the negative regulation of mitogen activated protein kinases (MAPK), and in particular to the regulation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). MAPKs play an important role in embryonic development, where their duration, magnitude, and spatiotemporal activity must be strictly controlled by other proteins, among others by DUSPs. In this study, we focused on the effect of DUSP7 depletion on the in vitro differentiation of mouse embryonic stem (ES) cells. We showed that even though DUSP7 knock-out ES cells do retain some of their basic characteristics, when it comes to differentiation, they preferentially differentiate towards neural cells, while the formation of early cardiac mesoderm is repressed. Therefore, our data indicate that DUSP7 is necessary for the correct formation of neuroectoderm and cardiac mesoderm during the in vitro differentiation of ES cells.
Discovery of Schistosoma mekongi circulating proteins and antigens in infected mouse sera
Authors: Uthailak Naphatsamon , Adisakwattana Poom , Thiangtrongjit Tipparat , Limpanont Yanin , Chusongsang Phiraphol , Chusongsang Yupa , Tanasarnprasert Kanthi , Reamtong Onrapak
Published: October 2022

Schistosomiasis is a neglected tropical disease caused by an infection of the parasitic flatworms schistosomes. Schistosoma mekongi is a restricted Schistosoma species found near the Mekong River, mainly in southern Laos and northern Cambodia. Because there is no vaccine or effective early diagnosis available for S. mekongi, additional biomarkers are required. In this study, serum biomarkers associated with S. mekongi-infected mice were identified at 14-, 28-, 42-, and 56-days post-infection. Circulating proteins and antigens of S. mekongi in mouse sera were analyzed using mass spectrometry-based proteomics. Serine protease inhibitors and macrophage erythroblast attacher were down-regulated in mouse sera at all infection timepoints. In addition, 54 circulating proteins and 55 antigens of S. mekongi were identified. Notable circulating proteins included kyphoscoliosis peptidase and putative tuberin, and antigens were detected at all four infection timepoints, particularly in the early stages (12 days). The putative tuberin sequence of S. mekongi was highly similar to homologs found in other members of the genus Schistosoma and less similar to human and murine sequences. Our study provided the identity of promising diagnostic biomarkers that could be applicable in early schistosomiasis diagnosis and vaccine development.
Role of fluid-phase complement system regulation in the development of hepatitis C virus-associated glomerulonephritis
Authors: Ibrahim Sara T. , Abdelhamid Marwa R. , Lewis Neveen , Baddour Nahed , Adam Ahmed G.
Published: October 2022

Objectives

It is not known why only some hepatitis C virus (HCV) infected patients develop glomerulonephritis (GN). Therefore, we investigated the role of soluble complement regulators in the development of HCV associated GN.

Methods

Patients with HCV associated GN who were admitted to our nephrology unit between July 2016 and July 2018 were recruited to the study (group 1). Two other age and sex matched groups were studied as control groups: patients with HCV without GN (group 2) and healthy HCV negative volunteers (group 3). There were 26 participants in each of the three groups at the end of the recruitment period. An assay of serum fluid-phase complement regulators was performed using enzyme linked immunosorbent assay technique. Three complement single nucleotide polymorphisms (SNPs) were analyzed using real time polymerase chain reaction (Taqman; thermo fisher scientific): rs2230199 and rs1047286 for complement 3 (C3) and rs800292 for complement factor H (CFH).

Results

Serum levels of complement 4 binding protein (C4BP) were significantly lower in group 1 (median 70 ng/ml) than in groups 2 (median 88.8 ng/ml) and 3 (median 82.8 ng/ml) with p value of 0.007. The minor allele (allele A) of rs800292 for CFH was significantly higher in group 2 and group 3 (G 54% and A 46%) than in group 1 (G 73% and A 27%), p = 0.04.

Conclusions

Low C4BP levels are associated with GN in HCV infected patients. In addition, rs800292 SNP in CFH protects against GN in patients with HCV.
Allelic variation of Escherichia coli outer membrane protein A: Impact on cell surface properties, stress tolerance and allele distribution
Authors: Liao Chunyu , Santoscoy Miguel C. , Craft Julia , Anderson Chiron , Soupir Michelle L. , Jarboe Laura R.
Published: October 2022

Outer membrane protein A (OmpA) is one of the most abundant outer membrane proteins of Gram-negative bacteria and is known to have patterns of sequence variations at certain amino acids—allelic variation—in Escherichia coli. Here we subjected seven exemplar OmpA alleles expressed in a K-12 (MG1655) ΔompA background to further characterization. These alleles were observed to significantly impact cell surface charge (zeta potential), cell surface hydrophobicity, biofilm formation, sensitivity to killing by neutrophil elastase, and specific growth rate at 42°C and in the presence of acetate, demonstrating that OmpA is an attractive target for engineering cell surface properties and industrial phenotypes. It was also observed that cell surface charge and biofilm formation both significantly correlate with cell surface hydrophobicity, a cell property that is increasingly intriguing for bioproduction. While there was poor alignment between the observed experimental values relative to the known sequence variation, differences in hydrophobicity and biofilm formation did correspond to the identity of residue 203 (N vs T), located within the proposed dimerization domain. The relative abundance of the (I, δ) allele was increased in extraintestinal pathogenic E. coli (ExPEC) isolates relative to environmental isolates, with a corresponding decrease in (I, α) alleles in ExPEC relative to environmental isolates. The (I, α) and (I, δ) alleles differ at positions 203 and 251. Variations in distribution were also observed among ExPEC types and phylotypes. Thus, OmpA allelic variation and its influence on OmpA function warrant further investigation.
Scoop thrombectomy: A declotting technique for the treatment of thrombosed autologous arteriovenous fistula. A single-center retrospective study
Authors: Ruan Lin , Yang Yanli , Ren Guangwei , Li Wen , Sun Lijun , Zhang Lihong
Published: October 2022

Background

Thrombosis is one of the main complications leading to the failure of autologous arteriovenous fistula (AVF) for patients with renal failure. Thrombectomy is one of the major therapies to remove thrombi to salvage the AVF and prolong its patency.

Materials and methods

Fifty-six patients with AVF thrombosis at the anastomosis were recruited for this study and underwent thrombectomy procedures. Their clinical variables were collected. The vasculature was accessed at the site of the aneurysmal dilatation. Under ultrasound guidance, a scoop thrombectomy procedure was performed by anterograde and retrograde scooping to remove the thrombus using forceps. Then, a sheath was placed in the direct vertical direction. Angioplasty was performed with a balloon to treat the underlying primary arteriovenous stenosis. Patients were followed up for 12 months after surgery. The procedural success, primary and secondary patency rates, and incidence of procedure-related complications were analyzed.

Results

There were 2 minor (3.6%) and no major complications. Clinical success was achieved in 55 of the 56 procedures (98.2%). No symptomatic pulmonary embolism or arterial embolization was noted. The primary patency rates at 3, 6, and 12 months were 92.9, 83.8, and 73.3%%, respectively, according to the Kaplan–Meier survival analysis.

Conclusion

Scoop thrombectomy is a safe procedure with high technical success and a low complication rate, and it is an effective method for patients to receive hemodialysis immediately.
Not your Mother’s MAPKs: Apicomplexan MAPK function in daughter cell budding
Authors: O’Shaughnessy William J. , Dewangan Pravin S. , Paiz E. Ariana , Reese Michael L.
Published: October 2022

Reversible phosphorylation by protein kinases is one of the core mechanisms by which biological signals are propagated and processed. Mitogen-activated protein kinases, or MAPKs, are conserved throughout eukaryotes where they regulate cell cycle, development, and stress response. Here, we review advances in our understanding of the function and biochemistry of MAPK signaling in apicomplexan parasites. As expected for well-conserved signaling modules, MAPKs have been found to have multiple essential roles regulating both Toxoplasma tachyzoite replication and sexual differentiation in Plasmodium. However, apicomplexan MAPK signaling is notable for the lack of the canonical kinase cascade that normally regulates the networks, and therefore must be regulated by a distinct mechanism. We highlight what few regulatory relationships have been established to date, and discuss the challenges to the field in elucidating the complete MAPK signaling networks in these parasites.
Glaesserella parasuis serotype 5 breaches the porcine respiratory epithelial barrier by inducing autophagy and blocking the cell membrane Claudin-1 replenishment
Authors: Liu Mingxing , Wang Qing , Wu Wenda , Chen Min , Zhang Pengyun , Guo Mengru , Lin Huixing , Ma Zhe , Zhou Hong , Fan Hongjie
Published: October 2022

Glaesserella parasuis(G.parasuis), the primary pathogen of Glässer’s disease, colonizes the upper respiratory tract and can break through the epithelial barrier of the respiratory tract, leading to lung infection. However, the underlying mechanisms for this adverse effect remain unclear. TheG.parasuisserotype 5 SQ strain (HPS5-SQ) infection decreased the integrity of piglets’ lung Occludin and Claudin-1. Autophagy regulates the function of the epithelial barrier and tight junction proteins (TJs) expression. We tested the hypothesis that HPS5-SQ breaking through the porcine respiratory epithelial barrier was linked to autophagy and Claudin-1 degradation. When HPS5-SQ infected swine tracheal epithelial cells (STEC), autophagosomes encapsulated, and autolysosomes degraded oxidatively stressed mitochondria covered with Claudin-1. Furthermore, we found that autophagosomes encapsulating mitochondria resulted in cell membrane Claudin-1 being unable to be replenished after degradation and damaged the respiratory tract epithelial barrier. In conclusion,G.parasuisserotype 5 breaks through the porcine respiratory epithelial barrier by inducing autophagy and interrupting cell membrane Claudin-1 replenishment, clarifying the mechanism of theG.parasuisinfection and providing a new potential target for drug design and vaccine development.
Linaclotide Reduced Response Time for Irritable Bowel Syndrome With Constipation Symptoms: Analysis of 4 Randomized Controlled Trials
Authors: Brenner Darren M. , Lacy Brian E. , Ford Alexander C. , Bartolini Wilmin , Wu James , Shea Elizabeth P. , Bochenek Wieslaw , Boinpally Ramesh , Almansa Cristina
Published: October 2022

INTRODUCTION:

These post hoc analyses provide clinically relevant data concerning time to response for individual irritable bowel syndrome with constipation (IBS-C) symptoms after linaclotide use.

METHODS:

Time-to-response data were pooled from 4 randomized controlled trials. Response time for abdominal symptoms (pain, discomfort, and bloating) and complete spontaneous bowel movements (CSBMs) were analyzed using the Kaplan-Meier method; patients were categorized as early responders (≤4 weeks), late responders (>4–12 weeks), or nonresponders.

RESULTS:

Among 2,350 patients (1,172 placebo and 1,178 linaclotide 290 μg), >50% of patients with IBS-C who initiated linaclotide treatment experienced a decrease of ≥30% in abdominal pain, discomfort, or bloating within 3–4 weeks (median). The median time to achieving ≥3 CSBMs was 4 weeks. Although not all linaclotide-treated patients responded within 12 weeks, a late response occurred between 4 and 12 weeks in 1 in 6 patients for abdominal pain and in approximately 1 in 10 patients for CSBM frequency. Comparisons of early responders, late responders, and nonresponders for both response definitions indicated that women, Whites, and patients with less severe baseline abdominal symptoms were more likely to respond early.

DISCUSSION:

Although treatment responses with linaclotide occurred in >50% of patients with IBS-C within 4 weeks of treatment initiation, benefits for individual abdominal symptoms and/or CSBM frequency can still occur between 4 and 12 weeks. A lack of improvement in one symptom does not negate the possibility of response for others, highlighting the importance of discussing all symptoms with patients and not assuming treatment futility at 4 weeks.
Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition
Authors: Botteri Edoardo , Peveri Giulia , Berstad Paula , Bagnardi Vincenzo , Chen Sairah L.F. , Sandanger Torkjel M. , Hoff Geir , Dahm Christina C. , Antoniussen Christian S. , Tjønneland Anne , Eriksen Anne Kirstine , Skeie Guri , Perez-Cornago Aurora , Huerta José María , Jakszyn Paula , Harlid Sophia , Sundström Björn , Barricarte Aurelio , Monninkhof Evelyn M. , Derksen Jeroen W.G. , Schulze Matthias B. , Bueno-de-Mesquita Bas , Sánchez Maria-Jose , Cross Amanda J. , Tsilidis Konstantinos K. , De Magistris Maria Santucci , Kaaks Rudolf , Katzke Verena , Rothwell Joseph A. , Laouali Nasser , Severi Gianluca , Amiano Pilar , Contiero Paolo , Sacerdote Carlotta , Goldberg Marcel , Touvier Mathilde , Freisling Heinz , Viallon Vivian , Weiderpass Elisabete , Riboli Elio , Gunter Marc J. , Jenab Mazda , Ferrari Pietro
Published: October 2022

INTRODUCTION:

We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort.

METHODS:

We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI).

RESULTS:

Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI ≤ 9) had a higher CRC risk (HR 1.34; 95% CI 1.02–1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59–1.00) than those remaining in the bottom tertile.

DISCUSSION:

Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention.
Twitter ontem e hoje
Authors: Falconi-Pires Livia Maria , Lourenço Julia
Published: October 2022

Neste trabalho tecemos algumas observações especificamente sobre a etapa metodológica do trabalho científico sobre o tema, tendo como objetivo principal refletir sobre as dificuldades nas etapas de recorte, tratamento e análise dos discursos produzidos on-line, particularmente no contexto da web 2.0. A diacronia que permeia esta pesquisa desvela os movimentos que, na sincronia, o/a pesquisador/a em ciências da linguagem realiza para analisar o discurso digital, partindo do pressuposto de que "a construção do corpus e a análise estão intimamente ligadas [pois] decidir o que faz parte do corpus já é decidir acerca de propriedades discursivas" (ORLANDI, 2009, p. 63). Nossa hipótese geral é a de que a perspectiva diacrônica pode iluminar o fazer científico, revelando os diversos funcionamentos discursivos do Twitter ontem e hoje, bem como a própria evolução social da rede. Para tal empreitada pressupomos que desde a construção do corpus, quanto dos observáveis (PAVEAU, 2021), até o posicionamento epistemológico e social do/a pesquisador/a, mudanças importantes podem ser assinaladas. Para além de apontar somente as diferenças pretendemos, sobretudo, contribuir com os debates científicos atuais que vêm sendo encaminhados nos estudos do discurso.
An Assessment of Water and Soil Losses in Pastures of The Brazilian Savanna Using Simulated Rainfall
Authors: Confessor Jefferson Gomes , Silva Lara Luíza , Araújo Paula Meirilane Soares
Published: October 2022

Pastures occupy a large part of Brazilian national territory, being of heterogeneous characteristics and varying in climate, fertility, and management. Water erosion, generated by the action of rainfall, is a principal source of soil depletion. These soils exhibit distinct behaviors spatially and temporally. Therefore, this research aims to evaluate the water and soil losses in a pasture of the Cerrado region during two periods of the year (winter and summer) with the aim of understanding the hydro-geomorphological dynamic of the pastures in question. A rainfall simulator was calibrated at 64.34 mm/h, to replicate similar intensities to those of the study region, for 30 minutes (32.17 mm) over four erosion plots. Overall, the plots presented low water and sediment losses, with the largest runoff volumes in the summer and the highest erosion rates in winter. These results are connected to seasonal climate variations expressed in the region, which are reflected in the plant growth habits, generating alterations in the structural quality of the pastures. It follows that the return of the rainy season (winter-summer transition) represents a critical phase for the triggering of the erosive process.
Improved Right Ventricular Systolic Function After Cardiac Resynchronization Therapy in Patients With Heart Failure
Authors: Sadeghian Hakimeh , Kazemisaied Ali , Rezvanfard Mehrnaz , Jalali Arash , Sadeghian Afsaneh , Ashraf Haleh , Semnani Farbod , Raeini Amirhossein Ghaseminejad
Published: October 2022

Background

Since the introduction of cardiac resynchronization therapy (CRT) to improve left ventricular function, the effect of CRT on the right ventricle in patients with heart failure has not been well described.

Methods

We evaluated the effect of CRT on right ventricular systolic function in 20 patients (80% men; mean [SD] age, 58.5 [9.8] y) with cardiomyopathy and right ventricular systolic dysfunction (New York Heart Association class III or IV, left ventricular ejection fraction ≤35%, and QRS interval ≥120 ms). The median follow-up time was 15 months. Right ventricular systolic function, defined as a tricuspid annular plane systolic excursion (TAPSE) index of 16 mm or less, was evaluated in patients before and after CRT.

Results

Twelve (60%) patients had ischemic cardiomyopathy, and 12 (60%) patients had left bundle branch block detected using surface electrocardiogram. The mean (SD) QRS duration was 160.5 (24.4) ms. From before CRT to the time of follow-up after CRT, the mean (SD) ejection fraction increased significantly from 22.5% (5.6%) to 29.4% (7.4%) (P < .001). The mean (SD) TAPSE index also increased significantly from 13.70 (1.78) mm to 16.50 (4.77) mm (P = .018). Eleven (55%) patients showed improved right ventricular systolic function (TAPSE ≥16 mm) after CRT. Patients with a favorable right ventricular response to CRT were significantly older (64.6 [8.2] y vs 53.6 [8.4] y, respectively) and more likely to have nonischemic origin of cardiomyopathy than were patients with unimproved right ventricular function (66.7% vs 18.2%, respectively).

Conclusion

Our findings indicate that CRT is associated with improved right ventricular systolic function in patients with heart failure and right ventricular systolic dysfunction. Patients with nonischemic heart disease more often show improved right ventricular function after CRT.
Violations of social regulation and traffic accidents in road freight transport
Authors: Beňuš Ján , Poliak Miloš , Lazaroiu George
Published: October 2022

The aim of the work is to analyze violations of social regulation in road freight transport and to propose solutions to prevent these violations. In the first part, we devoted ourselves to the processing of knowledge about road freight transport based on the legislation of the European Union, which is directly oriented to the conditions for the operator of road freight transport with vehicles over 3.5-tons of total weight. Since compliance with the rules also comes with their violations, it is also necessary to consider the traffic accident rate in road freight transport, we specifically identified and compared the traffic accident rate in road freight transport based on traffic accident statistics published on the website of the Ministry of the Interior. In the second part, we gradually processed and evaluated a questionnaire survey, which consisted of questions focused on the violation of social legislation by drivers. In the final part of the work, based on the analysis from the first part of the work and the results from the questionnaire survey in the second part, we proposed solutions to prevent the most frequent violations of social legislation by drivers and carriers.
Perubahan Harga Lahan di Sekitar Kawasan Perkantoran Pemerintah Kota Pekanbaru
Authors: Handayani Nadiah , Wibisono Bambang Hari
Published: October 2022

Pemerintah Kota Pekanbaru telah melakukan pembangunan kawasan baru untuk mewadahi kegiatan perkantoran pemerintah yang semakin berkembang, yaitu wilayah Kelurahan Negeri. Kelengkapan fasilitas pelayanan yang tersedia di pusat kota mengakibatkan konsentrasi kegiatan di daerah tersebut paling tinggi. Harga lahan di pusat kota memiliki kecenderungan lebih mahal jika dibandingkan dengan harga lahan yang ada di pinggir kota. Pembangunan kawasan perkantoran pemerintah kota membentuk mini peak yang ada di pinggir Kota Pekanbaru. Tujuan dari penelitian ini adalah untuk mengidentifikasi pengaruh pembangunan kawasan perkantoran pemerintah kota terhadap perubahan harga lahan dan faktor-faktor yang mempengaruhi harga lahan selain pembangunan tersebut. Data dianalisis secara kualitatif dengan memetakan dan membandingkan perubahan harga lahan berupa NJOP yang muncul di kawasan sekitarnya sebelum dan sesudah pembangunan (tahun 2012 hingga 2019) dan membuat kesimpulan dari hasil wawancara. Penelitian ini menunjukkan hasil bahwa harga lahan di sekitar pembangunan kawasan perkantoran pemerintah kota mengalami perubahan NJOP yang semakin meningkat karena pengaruh dari pembangunan tersebut. Terdapat faktor-faktor lain yang mempengaruhi perubahan harga lahan, yaitu aksesibilitas, lokasi, ketersediaan fasilitas dan legalitas lahan, NJOP, fasilitas umum dan fasilitas sosial, serta permintaan dan penawaran.
Zur Idee der Freiheit
Authors: Stemmer Peter
Published: October 2022

European culture is distinguished by a special and indeed unique appreciation of freedom. Understanding why we care so much about freedom requires continual reflection on the heart of the matter. This is especially necessary because the concept of freedom has been constantly reworked and remodelled throughout its long history. This article lists five key characteristics and highlights two in particular: (1) the openness of being free, which means that freedom does not itself determine what it is used for; and (2) the fact that freedom is by its nature an extrinsic, not an intrinsic, end. In addition, the article comments on various highly influential aberrations in the explication of the idea of freedom that began early, in the 4th century, with Plato.
Konkrete Geschichtlichkeit?
Authors: Romero José M.
Published: October 2022

This article reconstructs Herbert Marcuse’s first and widely ignored philosophical project, as set out in his texts published from 1928 to 1933. In these texts, Marcuse tried to put in dialogue ideas from Heidegger and Marx to articulate a dialectic phenomenology of historical existence. This attempt, of great originality and philosophical ambition, was marked by tensions arising from the peculiar status given to the ontology of historicity in a framework of thought that maintained strong links with Marx. By analysing this early philosophical project of one of the icons of the international student movement, theoretical tensions can be detected, which clarify the subsequent approach of this thinker as a member of the so-called Frankfurt School.
„Gerstenberg ist unser gröste Poet vielleicht…“
Authors: Paulsen Adam
Published: October 2022

Although they never met and exchanged only one letter during their lifetime, Danish-German poet and literary critic Heinrich Wilhelm Gerstenberg and German theologian, philosopher and literary critic Johann Gottfried Herder took great interest in each other’s work. Indeed, during the late 1760s Gerstenberg’s writings on literature, history and translation arguably had an immense impact on Herder, providing him with some of the major themes and insights for the Sturm und Drang movement, that took place in Germany around 1770 with Herder in a leading role. On the basis of Herder’s writings and letters from the 1760s throughout his life, this article examines for the first time to what extent Gerstenberg informed Herder’s views on ancient Nordic literature, Shakespeare, Ossian and the concept of genius.
Naturens Amfiteater. Kunstens natur
Authors: Klitgaard Povlsen Karen
Published: October 2022

Friederike Brun, née: Münter (1765–1835) became a famous writer in the German-speaking areas of Europe around 1800. She published collections of poems and travelogues in German, brought up as she was in the German and cosmopolitan circle in Copenhagen around Klopstock, Gerstenberg, her father, court chaplain Balthasar Münter, and others. Not least the writings of Ossian (MacPherson), Shakespeare, Gray and Richardson influenced her together with J. J. Rousseau. This contribution focuses on her early writings from 1782 until 1790. They have so far been neglected in research, being the products of a young woman, but they show the wide horizon of her circle, her father’s education of her, his introduction of her to the German intellectual elite of the time and her talent as a writer in a sentimental and enlightened-romantic tradition inspired by Schiller and Herder. She is interested in the aesthetics of nature and the relations between nature and culture and can in this respect be seen as an early ecocritical writer. Furthermore, she demonstrates female emancipation around 1800 and a cosmopolitical consciousness in a Europe heading towards national boundaries as well as language and gender barriers.
Auswirkungen der Corona-Pandemie auf das freiwillige Engagement älterer Menschen in der Schweiz
Authors: Kirchschlager Stephan , Störkle Mario
Published: October 2022

Der Beitrag stellt die Ergebnisse einer Studie aus der Schweiz ins Zentrum, die sich mit den Auswirkungen der Corona-Pandemie auf das Engagement von Menschen im höheren Lebensalter sowie auf deren persönliche Lebenssituation als Zugehörige einer Risikogruppe beschäftigt. Die Studie zeigt, wie die Befragten ihr Leben auch während der Pandemie aktiv gestalten und Wege finden, ihr Engagement fortzuführen. Bei den Befragten ambivalent bleibt insbesondere der Aspekt, sich einerseits fit, gesund und aktiv zu fühlen und andererseits pauschal zur vulnerablen Gruppe zu gehören.
Financial Instability and International-Lender-of-Last-Resort Theory from the Gold Standard to the Dollar System
Authors: Carré Emmanuel , Le Maux Laurent
Published: October 2022

We identify two approaches to financial crises in the history of political economy, namely, the exogenous approach whereby financial crises are sudden events, and the endogenous approach whereby they arise from a long process. In focusing on the endogenous approach, we study the contributions by Thomas Tooke, Ralph Hawtrey, Hyman Minsky and Charles Kindleberger to the lender-of-last-resort theory, especially in international contexts, under the gold standard and the dollar system. The function of the lender of last resort broadens institutionally (depending on the type of securities and on the institutions issuing or holding them) and internationally (depending on jurisdiction and on the type of institutions ultimately requiring international liquidity).
Benefitting from the Development of the Bioeconomy: the Case of Bulgaria
Authors: Kotseva-Tikova Maria
Published: October 2022

The bioeconomy is a concept predominantly addressing industries producing and processing biological products with the aim of
making them contribute to the transformation of modern economies into more sustainable, green, circular and climate-neutral economies.
The aim of the article is to study the benefits of the development of the bioeconomy in Bulgaria, seen as economic, security
and climate change impacts. All of these require a balanced management of biomass application, especially for non-food purposes,
in order to obtain positive impacts and avoid the degradation of the ecosystem. For these reasons, different approaches to the governance
of the bioeconomy are adopted worldwide. Bioeconomic industries in Bulgaria are vulnerable to climate change, and need
investment to adapt to it. The main bioindustries are agriculture and food processing with respect to value added and employment,
as they are of low efficiency in comparison with EU results. These sectors show resilience in the case of health risks and need technological
modernisation and efficiency improvement through new supply chains and approaches to waste management. Renewable
energy generation was stable during Covid-19 lockdowns, and impacted positively the decrease in greenhouse emmissions. Along
with the ecological benefits, RES increases energy diversification and contributes to national security.
Demokratijos legitimumas krizės sąlygomis: teorinis požiūris
Authors: Obrikienė Alvyda , Šiliauskas Saulius
Published: October 2022

XXI amžiaus demokratinėje realybėje atotrūkis tarp piliečių lūkesčių ir tikrovės gilėja. Demokratija neatitinka demokratijos idealo,
jos plėtra yra sudėtinga ir stringanti. Demokratinė politinė tvarka ir demokratijos legitimacija priklauso nuo suvereniteto, atstovavimo,
dalyvavimo ir lygybės principų įgyvendinimo. Kai demokratijai kyla šių principų užtikrinimo problemų, ja imama abejoti ir ją
kritikuoti tiek visuomenėje, tiek moksliniame diskurse. Visuomenės nuomonės tyrimai vis dar rodo piliečių pritarimą pagrindinėms
demokratijos vertybėms, bet neveiksmingos institucijos kelia grėsmę demokratijai. Siekiant įgyvendinti tikslą, taikytas mokslinės
literatūros analizės metodas. Straipsnyje pristatomi debatai dėl demokratijos krizės, įvertinant demokratijos legitimaciją, taikant
metodologinę politinės filosofijos prieigą. Straipsnį sudaro trys dalys, pirmiausia peržvelgiant bendrąsias šiuolaikinės demokratijos
raidos tendencijas bei debatus dėl demokratijos krizės, aptariant suvereniteto, atstovavimo ir didėjančios nelygybės visuomenėje deformacijas,
užbaigiama trečia straipsnio dalimi, kur pasitelkus visuminio legitimumo analitinę perspektyvą įvertinamas demokratijos
krizės diskurso įžvalgų poveikis normatyviniam demokratijos legitimumui, t. y. piliečių moralinei savivokai.
Vadovų požiūrio į darbuotojų asmenines ir organizacines pasipriešinimo technologiniams pokyčiams priežastis kokybinis tyrimas
Authors: Paulikienė Birutė , Paulikas Julius
Published: October 2022

Organizacijų gebėjimas sklandžiai diegti technologinius pokyčius savo veikloje yra vienas esminių veiklos sėkmės veiksnių. Technologinių
pokyčių diegimo nesėkmes dažnai lemia ne technologiniai, o žmogiškieji aspektai. Straipsnyje tiriamas viešojo keleivinio
transporto įmonių vadovų požiūris į jų organizacijų darbuotojų pasipriešinimo technologiniams pokyčiams priežastis, analizuojami
asmeninių ir organizacinių pasipriešinimo pokyčiams priežasčių skirtumai. Kokybinio tyrimo – organizacijų vadovų interviu – rezultatai
atskleidė, kad pagrindinės pasipriešinimo pokyčiams priežastys priklauso nuo asmenybės, o svarbiausias pasipriešinimo
impulsas – nerimas ir baimė, pabrėžta amžiaus ir išsilavinimo svarba šiam poveikiui. Atlikus tyrimą nustatyta, kad organizacinės
priešinimosi pokyčiams priežastys yra ne pačios svarbiausios, nes darbuotojams užtikrinus esmines darbo sąlygas, nesant baimės
būti atleistiems, smulkūs darbo organizavimo pokyčiai darbuotojų pasipriešinimo technologiniams pokyčiams neskatina.
Savanorių pritraukimo į ne pelno siekiančias organizacijas priemonės
Authors: Vaicekavičienė Jolanta , Petrulis Arnoldas
Published: October 2022

Ne pelno siekiančių organizacijų vykdomų veiklų sėkmė daugeliu atvejų priklauso nuo savanorių. Straipsnyje aptariamos ne pelno
siekiančios organizacijos ir savanorystė. Remiantis mokslinės literatūros šaltiniais, pateikiamos ne pelno siekiančių organizacijų ir
savanoriškos veiklos sampratos, skiriami savanorių pritraukimo vadybiniai aspektai, į kuriuos atsižvelgus pasirinkti tyrimo atlikimo
kriterijai. Nustatyta, kad savanorių patiriamų pagrindinių išlaidų kompensavimas paskatintų juos įsitraukti į ne pelno siekiančių
organizacijų veiklą. Apibendrinus savanorių ir organizacijų darbuotojų (ekspertų) tyrimo duomenis, atskleisti savanorių pritraukimo
į organizacijos veiklą motyvuojantys veiksniai.
Dangers and Opportunities in the Development of Borderlands: the Case of the Warmia and Mazury Region (Selected Issues)
Authors: Żęgota Krzysztof
Published: October 2022

The article deals with the issue of dangers and opportunities in the development of the Warmia and Mazury region in the context
of being in the neighbourhood of the Kaliningrad region of the Russian Federation. The aim of the article is to present selected
conditions of functioning of the Warmia and Mazury region as a border region neighbouring the Kaliningrad region of the Russian
Federation, as well threats related to the military potential of the Kaliningrad region. The border location of the Warmia and Mazury
region deepens its peripherality both from the point of view of economic development and its influence on the policy of the Polish
central authorities. A significant barrier to the development of the region was the introduction of the visa regime on the Polish-Russian
border before Poland’s accession to the European Union. Another factor in cross-border relations was the introduction of the
local border traffic mechanism, which facilitated border crossings from 2012 to 2016. Since 2014, Polish-Russian relations have been
deteriorating at the political level. This has made it necessary to treat the Kaliningrad region as a potential source of danger to Poland.
The Russian invasion of Ukraine, launched in February 2022, further aggravated this trend.
ESTUDO DA PRESENÇA DO ALELO MUTANTE MDR1 NA RAÇA OVELHEIRO GAÚCHO E SUA CONTRIBUIÇÃO PARA A MEDICINA VETERINÁRIA E CRIAÇÃO DE CÃES DE RAÇA PURA
Authors: Rosa Cunha Felipe , Nunes Garcia Élen , Fagonde Silva Éverton , Hellen Bastos Lavadouro Jéssica , Pessoa Araújo Júnior João , Silva da Rosa Cristiano
Published: October 2022

De acordo com a Associação dos Criadores de Ovelheiro Gaúcho (ACOG), esta raça canina tem como seus ascendentes históricos os cães da raça Cão da Serra da Estrela, vindos de Portugal, e os Scotch Collie, vindos da Inglaterra e Escócia. Sendo o Ovelheiro Gaúcho uma raça bastante comum no Rio Grande do Sul (Brasil) e no Uruguai, e com a cinofilia cada dia mais presente no meio acadêmico, devemos conhecer as características clínicas e genéticas que a raça pode ter herdado na sua formação. Uma das mais conhecidas é a sensibilidade específica a determinadas drogas, sabidamente presente em algumas raças que compartilham a mesma ancestralidade, como os Collies, associada ao gene mutante de resistência a múltiplas drogas conhecido como MDR1, cuja mutação causa aumento na suscetibilidade aos efeitos neurotóxicos de determinadas drogas. Assim, o objetivo do presente trabalho foi determinar a presença do gene mutante MDR1 na raça Ovelheiro Gaúcho. Para tanto, foram encaminhadas amostras sanguíneas de 25 cães, devidamente registrados pela ACOG, ao Laboratório de Diagnóstico Molecular, UNESP, Botucatu, a fim de realizar a genotipagem por meio de reação em cadeia da polimerase (PCR). No presente estudo, obteve-se uma frequência alélica de 26% na amostra (95% IC = 12,9% - 45,6%). Os resultados, inéditos, são importantes para a afirmação da presença do alelo mutante na raça e, com isso, auxiliar o Médico Veterinário em sua conduta terapêutica, reduzindo os riscos de intoxicação do paciente. Como essa frequência ainda é baixa, e não foram encontrados animais homozigotos mutantes, é possível selecionar reprodutores sem a presença desse mutante para eliminar esse alelo da população e contribuir para o desenvolvimento da raça.
Features of the Development of Soft and Hard Skills in People of Generation Z
Authors:   Novosibirsk State Pedagogical University, Mavrin Anatoly S.
Published: October 2022

The content of the article is devoted to the description of interests, psychological and outlook characteristics of representatives of the generation of people born between 1997 and 2016, the so-called digital generation Z. They are “environmentally friendlyˮ, strive for freedom and the absence of financial burdens that tie a person to life in one place, gravitate towards individualism and lonely pastime. The article presents the results of scientific research by Microsoft, the Center for Generation Kinetics, psychotherapist W. Kruger, sociologist K. M. Franklin, psychologist D. McClelland and other scientists devoted to the study of the attention span of modern people, attitudes towards money and financial literacy of buzzers, the role friendship and family in public relations, the formation of empathy through communication in social networks. The essence of the concept of lifelong learning is highlighted, the purpose of which is to educate a person throughout life, where the role of a teacher can be transformed from a retransmitter of knowledge for the younger generation into tutoring or mentoring, mentoring or coaching. The characteristic of soft and hard skills of in children from 3 to 18 years old is presented in order to successfully socialize the individual and professional effectiveness in a digital society. The classification of soft skills is indicated, which includes 3 main groups: cognitive, social and emotional. Examples of the development of educational activities of key competencies soft and hard skills in children of different age groups are given. In conclusion, it is noted that soft and hard skills are characterized by universality.
Cultural Victimogenesis of Personality: Clinical and Victimological Concept of Development Victimization Mentalization of a Teenager
Authors: Rudensky Evgeny V.
Published: October 2022

The authorʼs concept of cultural victimogenesis of the psyche is presented, which formed the basis of the psychology of deficient personality development created by the author (cultural and genetic psychology of victimogenesis), three psychological theories of victim personality (socio-psychological victimology of personality; socio-pedagogical victimology of personality; psychological victimology of personality) and became the conceptual foundation of the scientific school of social psychology of clinical victimology of personality and the innovative direction of modern socio-psychological practice of personality devictimization – drama-sociatry as a unity of didactic drama-sociatry; clinical drama-sociatry and cultural-analytical drama-sociatry.
Psychological Correction of Higher Mental Functions of Preschoolers of the Speech Therapy Group by Means of Educational Kinesiology
Authors:   Novosibirsk State Pedagogical University, Yaschenko Anna V.
Published: October 2022

The article describes experimental work on the psychological correction of higher mental functions of pupils of preschool speech therapy groups of kindergarten combined type. The purpose of the study is to identify the effectiveness of the use of educational kinesiology in the development of higher mental functions of preschoolers with speech disorders. Based on the study of higher mental functions by the method of “Express diagnosticsˮ by N. N. Pavlov and A. G. Rudenko, the features of attention, memory, thinking, speech, perception and imagination in preschoolers with speech disorders were revealed. The program of work of a teacher-psychologist and the results of its application are described. The author comes to the conclusion that preschoolers with speech disorders of the experimental group experienced a significant increase in such mental processes as “Thinkingˮ and “Speech and thinkingˮ.
Patient journey experiences may contribute to improve healthcare for patients with rare endocrine diseases
Authors: Webb Susan M , Kristensen Jette , Nordenström Anna , Vitali Diana , Amodru Vincent , Wiehe Lenja Katharina , Bolz-Johnson Matt
Published: October 2022

Patient journeys are instruments developed by EURORDIS, The Voice of Rare Disease Patients in Europe, to collect patients’ experiences; they may identify gaps and areas deserving improvement, as well as elements positively considered by affected persons. As with other patient-reported experiences, they can complete the clinical evaluation and management of a specific disease, improving the often long diagnostic delay, therapy, patient education and access to knowledgeable multidisciplinary teams. This review discusses the utility of such patient-reported experience measures and summarises the experiences of patients with acromegaly, Addison’s disease and congenital adrenal hyperplasia from different European countries. Despite rare endocrine diseases being varied and presenting differently, feelings of not having been taken seriously by health professionals, family and friends was a common patient complaint. Empathy and a positive patient-centred environment tend to improve clinical practice by creating a trustworthy and understanding atmosphere, where individual patient needs are considered. Offering access to adequate patient information on their disease, treatments and outcome helps to adapt to living with a chronic disease and what to expect in the future, contemplating the impact of a disease on patients’ everyday life, not only clinical outcome but also social, financial, educational, family and leisure issues is desirable; this facilitates more realistic expectancies for patients and can even lead to a reduction in health costs. Patient empowerment with patient-centred approaches to these complex or chronic diseases should be contemplated more and more, not only for the benefit of those affected but also for the entire health system.