bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECT OF TAMARIND (TAMARINDUS INDICA) LEAF EXTRACT OINTMENT IN CONTROLLING THE GROWTH OF THE BACTERIA PROPIONIBACTERIUM ACNES THAT TRIGGERS ACNE
Authors: Azzahra Hasna , Shalihah Fianicha , Trisnawati Indah Nurlita , Aeniah Siti , Cahyani Lintang Prima , Saputra Alanindra
Published: February 2022

Tamarind (Tamarindus indica) is a versatile plant, findable in Indonesia (Java, Bali, North Sumatra, West Kalimantan, and South Sulawesi). The leaves are green to brown, round, 1-2.5 cm long and 4-8 mm wide, rounded tips, rounded base of blades, and flat edges. The content contained in tamarind leaves such as flavonoids, tannins, saponins, and alkaloids is believed to inhibit Propionibacterium acnes activity. This study aims to determine the effect of tamarind leaf extract ointment in controlling the growth of the bacteria Propionibacterium acnes that triggers acne. This study applied a Completely Randomized Design with 96% ethanol maceration method. Propionibacterium acnes was evidenced by the inhibition zone formed. The diameter of the inhibition zone of the 25% ointment was 1.235 cm, the 30% concentration was 1.385 cm, the 35% concentration was 1,680 cm, and the ointment base was 0 cm. The ANOVA test showed a significant value of 0.000<0.05, so there was a significant difference between the inhibition zone and the 95% confidence level. The results of Post Hoc test were P<0.05, meaning that there was a significant difference between the bases with formulas 1, 2, and 3. Thus, tamarind leaf extract ointment had a strong inhibitory effect on Propionibacterium acnes.
Labioplastia y técnicas de cirugía estética genital en Medellín, Colombia
Authors: Bojanini-Betancur Juan Fernando , Tavera-Agudelo Edison Andrés , Bonilla-Sepúlveda Óscar Alejandro
Published: February 2022

Introducción. La cirugía estética genital femenina presenta una creciente demanda; sin embargo, su técnica y resultados no son bien conocidos. Objetivos. Describir los datos sociodemográficos, manifestaciones clínicas, resultados postoperatorios y la satisfacción en un grupo de mujeres a quienes se aplicó cirugía estética genital femenina. Métodos. Estudio descriptivo, retrospectivo de una base de datos institucional, en el periodo 6 de marzo de 2007 a 14 de enero de 2021. Se analizó los datos demográficos y clínicos de los registros médicos utilizando estadística descriptiva. Resultados. Se recuperaron los datos de 713 pacientes, con edad media de 34,3 años y 12 de las cuales tenían menos de 18 años. Antes de la intervención, el 87,5 % (n= 624) de pacientes estaban inconformes con el aspecto de sus genitales externos, el 74,1 % (n= 528) tenía incomodidad con sus genitales y 53,4 % (n= 381) manifestaron pérdida de gratificación sexual. Los hallazgos más comunes al examen físico fueron la hipertrofia de los labios menores (n= 616; 86,4 %) y el capuchón de clítoris redundante (n= 577; 80,9 %). La cirugía más efectuada consistió en labioplastia (n= 609; 85,4%) y reducción del capuchón del clítoris (n= 564; 79,1 %). La satisfacción global a los 8 y 30 días fue de 99,4 % (n= 709) y 93,3 % (n= 665), respectivamente. Conclusiones. En la cohorte estudiada, las mujeres lograron altas tasas de satisfacción cosmética con los resultados quirúrgicos, y también experimentaron mejora en su satisfacción funcional. Existió una tasa baja de complicaciones.
Ascitis masiva secundaria a preeclampsia severa: reporte de caso
Authors: Tutal Muñoz Luis Miguel , Sandoval Molano Diana Patricia , Peralta Trejos Manuel , Briceño Méndez Freddy , Moreno Benavides Luisa Fernanda
Published: February 2022

La preeclampsia es una patología con múltiples implicaciones y causa de morbimortalidad materno perinatal. Aunque su frecuencia es baja, la ascitis es un signo clínico a tener en cuenta. Reportamos el caso de un embarazo de 33,1 semanas con preeclampsia severa, en quien durante la cesárea se observó ascitis que evolucionó a ascitis masiva al segundo día postoperatorio, y requirió manejo invasivo (drenaje por pig tail) y traslado a UCI por 6 días. Necesitó nitroprusiato durante 2 días por persistencia de la crisis hipertensiva, con mejoría progresiva y egreso de la clínica a los 12 días.
Carcinoma de células pequeñas extrapulmonar de mama. Reporte de caso
Authors: Torres-Cepeda Duly , Rondon-Tapia Martha , Reyna-Villasmil Eduardo
Published: February 2022

El carcinoma de células pequeñas representa 20% de los cánceres de pulmón; raramente ocurre en otros sitios. El carcinoma de células pequeñas extrapulmonar es agresivo, con propensión a la diseminación regional y a distancia. Este tipo de carcinoma es una neoplasia poco frecuente en mama. Aunque la apariencia clínica es inespecífica, a menudo responde bien a la terapia y tiene buen pronóstico de supervivencia. Se presenta el caso de mujer de 50 años con carcinoma de células pequeñas extrapulmonar de mama. El examen físico mostró lesión de 4 x 3 x 3 centímetros confirmada por resonancia magnética de la mama izquierda. El diagnóstico se realizó mediante biopsia que mostró las características células pequeñas, redondas, similares a linfocito con núcleos hipercromáticos y escaso citoplasma compatible con carcinoma de células pequeñas de mama. La paciente fue tratada con quimioterapia antes de ser sometida a mastectomía total y resección de los ganglios linfáticos.
منظومة العلم والتقنية في الوطن العربي: الواقع والمستقبل
Authors: بنت محمد الربان موزة
Published: February 2022

لا تزال منظومة البحث العلمي العربي تواجه تحديات بناء قدرات العلم والتكنولوجيا والابتكار، وجعلها جزءًا من المنظومة المجتمعية، ووضعها في مضمار التنافس العالمي، وهي تحتاج إلى التفكير الجاد والإرادة الصادقة والعمل الدؤوب لتغيير هذا الواقع. تتناول هذه الدراسة، بالدرس والتحليل، بعض مؤشرات مجتمع المعرفة ذات الصلة، من نسبة تمويل البحوث العلمية، أو عدد براءات الاختراع، أو عدد الباحثين من ذوي الاستشهادات العالية، أو مستوى الجامعات العربية في التصنيفات العالمية، وغيرها. بيد أننا نعتبرها جميعها نتائج وليست أسبابًا. ومن ثمّ، نسعى لتوضيح أنّ العلميين العرب لا تتوافر لهم البيئة التمكينية اللازمة للإنتاج الحقيقي والمفيد للمعرفة، وأنّ منظومة العلم والتقنية جزءٌ لا يتجزأ من المجتمع، تسوس أموره السياسة العامة للدولة، ويعكس نجاحه نجاحها وفشله فشلها.
Foreign Body Reaction with Granuloma 10 Years After Achilles Tendon Reconstruction with the LARS Ligament
Authors: Niazi Noman Shakeel , Niazi Noman Shakeel , Aljawadi Ahmed , Khan Munir , Pillai Anand
Published: February 2022

Achilles tendon rupture is one of the most common tendon injury in adult population. Synthetic ligament has been an attractive alternative for reconstruction chronic Achilles tendon tears. Ligament reconstruction with the LARS ligament has been a popular choice owing to its low-complication rates. LARS ligament is a non-absorbable synthetic ligament device. There are no long-term results of LARS ligament reconstruction for Achilles tendon reconstruction in literature. We describe a successful management of foreign body granuloma in a LARS ligament Achilles tendon graft and a technique to reconstruct the tendon following its excision.
The Role of Financial Technology (Fintech) in ZIS Management to Overcome Poverty
Authors: Zuliansyah A. , Pratomo Dimas , Supriyaningsih Okta
Published: February 2022

Indonesia's zakāh‎ potential is large enough to overcome poverty, but the Indonesian population living below the poverty line is still quite high, reaching 25.95 million people. These data indicate that the large potential of zakāh‎ has not contributed enough to poverty alleviation in Indonesia. To increase zakāh‎ collection, the Zakāh‎ Management Organization (OPZ) innovates by using fintech in its management. The study aims to see how the role of fintech in managing ZIS is to contribute to poverty alleviation in Indonesia. The method used is a qualitative method by analyzing data and facts obtained from the object under study namely; BAZNAS Central Jakarta and BAZNAS Prov. DIY 2020 descriptively and in detail. The results of the study indicate that fintech has played a significant role in increasing zakāh‎ collection over the last five years. It can be seen from the growth of zakāh‎ distribution from 2015 to 2019 experienced a significant increase, reaching an average of 40.93%.
Model of Sharia Bank Profitability Determination Factors by Measuring Internal and Externals Variables
Authors: Sihotang Mutiah Khaira , Hasanah Uswah , Hayati Isra
Published: February 2022

This study examines the influence of internal and external factors on profitability as proxied by Return on Assets (ROA), a study on Islamic Commercial Banks for the 2016-2020 period. In the theory of profitability, there are 2 factors that affect bank profitability, namely internal factors and external factors. Internal factors in this study are BOPO (Operating Expenses to Operating Income), Non-Performing Financing (NPF), Financial to Deposit Ratio (FDR) and external factors in this study are inflation and the money supply. Profitability is one of the most important factors in a company, including Islamic financial institutions, in this case Islamic banks, so that every company must pay attention to the company's profitability ratios. Islamic banks are financial institutions that just started to emerge in the late 90s and have a very high level of competition with conventional banks. For this reason, this study aims to look at the financial performance of Islamic banks in Indonesia through the level of profitability they have had for the last 5 years. The sample selection in this study used purposive sampling method. The sample in this study is the monthly financial statements of Islamic commercial banks in Indonesia in 2016-2020. The data in this study will be processed using SPSS software with multiple regression. The results of this study state that inflation as an external factor does not have a significant effect on the profitability of Islamic Commercial Banks as measured by the Return on Assets (ROA) ratio with a significance level of 0.628 and the money supply has a significant effect on ROA. While the BOPO, NPF and FDR variables as internal factors have a significant effect on ROA.
A Bibliometric and Altmetric Analysis and Visualization of Obsessive Compulsive Disorder: The Top 100 Most Cited Influential Studies
Authors: BAŞHAN Dilara Nurefşan
Published: February 2022

Obsessive-Compulsive Disorder [OCD] is a psychiatric/psychological disorder that can start in childhood, adolescence, or early adulthood and progress quite severely depending on age of onset, and several other reasons. It is characterized by obsessions and compulsions that repeat and cause significant distress in a person's life. While obsessions cause distress, compulsive behaviors can help alleviate the stress evoked by the obsessions albeit temporarily. When the bibliometric analysis of OCD was performed, it was observed that the existing studies were from several fields such as psychiatry, psychology, neuroscience, pharmacology, clinical psychology, pediatrics, biochemical molecular biology, genetics, and behavioral science. This multidisciplinary approach might be interpreted as an indication that OCD is a mental disorder that can be investigated through several frameworks. In this context, in this study, the first 100 most frequently cited articles on OCD were compiled and their bibliometric analysis was carried out. In this article, the types, categories, years of publication and citations of the top 100 most cited articles on the OCD issue, the most cited articles’ journals and their features, the origin of the publications and the relations between countries, the most influential universities and institutes with the top 100 most cited articles on OCD, abstract and keyword analysis of the top 100 articles about OCD which were created using data mining method, top 10 productive authors and current altmetric effects were included. It is thought that this study would guide the researchers from different professions for their future work on OCD.
Validation of the Ruptured Arteriovenous Malformation Grading Scale in a pediatric cohort
Authors: Garcia Joseph H. , Rutledge Caleb , Winkler Ethan A. , Carrete Luis , Morshed Ramin A. , Lu Alex Y. , Saggi Satvir , Fox Christine K. , Fullerton Heather J. , Kim Helen , Cooke Daniel L. , Hetts Steven W. , Lawton Michael T. , Gupta Nalin , Abla Adib A.
Published: February 2022

OBJECTIVE

Pediatric brain arteriovenous malformations (AVMs) are the leading cause of spontaneous intracranial hemorrhage (SICH) in children. Although the incidence of SICH is low in pediatric populations, such events cause substantial morbidity. The recently created Ruptured Arteriovenous Malformation Grading Scale (RAGS) is proposed as a reliable and novel grading system to specifically serve as a predictor of clinical outcomes in patients following AVM rupture, similar to the Hunt and Hess (HH) grade for ruptured aneurysms. While these data are promising, pediatric patients were notably absent from the original study validating the RAGS. Therefore, correlation of the RAGS score with clinical outcomes following AVM rupture in individuals younger than 18 years of age using the RAGS score is needed. The objective of this study was to validate the RAGS in a cohort of pediatric patients with AVMs who presented with hemorrhage, thereby demonstrating the score’s generalizability, and expanding its external validity.

METHODS

A cohort of children with ruptured AVMs were retrospectively reviewed. Using disability, measured by the modified Rankin Scale (mRS), as the response variable, the area under the receiver operating characteristic curve (AUROC) was calculated for patients based on their RAGS scores for three time periods. The AUROC values were then compared with those generated by two commonly used clinical grading systems, the HH classification and Glasgow Coma Scale.

RESULTS

A total of 81 children who presented with ruptured AVMs were included in the study, with a mean follow-up duration of 4 years. The RAGS score outperformed other clinical grading scales in predicting mRS scores, with AUROC values of 0.81, 0.82, and 0.81 at three distinct follow-up periods.

CONCLUSIONS

The RAGS score correlated well with the clinical outcome after AVM rupture in pediatric patients. Additional validation studies across multiple treatment centers are needed to further demonstrate the generalizability of the scoring system.
RETROSPECTIVE OBSERVATIONAL STUDY ON THE DYNAMICS OF SURGICAL TREATMENT OF COLON CANCER BEFORE AND DURING THE COVID 19 PANDEMIC. THE EXPERIENCE OF A SMALL CENTER
Authors:   Transilvania University, Faculty of General Medicine Brașov, Fugaretu C. , Misarca C. ,   Transilvania University, Faculty of General Medicine Brașov, Carnatiu A. ,   General Surgery Clinic I, Brașov County Emergency Clinical Hospital, Dumitrascu O. ,   General Surgery Clinic I, Brașov County Emergency Clinical Hospital
Published: February 2022

n March 2020, the World Health Organization declared COVID-19 a pandemic. The main purpose of this retrospective observational study is to highlight the diagnostic changes in the dynamics of surgical treatment of patients with colon cancer, hospitalized on Surgery I Department of Brasov County Emergency Clinical Hospital in the first year of the pandemic.A number of 129 patients diagnosed and surgically treated for colon cancer in the Surgery I Department of Brașov County Emergency Clinical Hospitalbetween March 1, 2019 and February 29, 2021 were included in the study.Later, the patients were divided into two groups, the first group includes patients diagnosed and treated for colon cancer one year before the pandemic and the second group, patients treated surgically in the first year of the pandemic. Several characteristics of the two groups were analyzed.We report a decrease in the number of cases in the first year of the pandemic due to restrictions and a decrease in early diagnosis, as well as a decrease in the number of laparoscopic approaches, an increase in the length of hospital stays during the pandemic and an increase in the percentage of perioperative deaths in Group 2. The limitations of the study are represented by the small number of patients as well as by the evaluation of the experience of a single Section from a single Center that does not allow the generalization of the results.
THE PREDICTIVITY OF RISK SCORES IN UPPER GASTROINTESTINAL BLEEDINGS
Authors:   Department  of  Fundamental,  Prophylacticand  Clinic  Disciplines,  Faculty  of  Medicine, Transilvania University of Brasov, Condrea E.G. , Lupu D. ,   Department  of  Fundamental,  Prophylacticand  Clinic  Disciplines,  Faculty  of  Medicine, Transilvania University of Brasov, Nedelcu L. ,   Department  of  Fundamental,  Prophylacticand  Clinic  Disciplines,  Faculty  of  Medicine, Transilvania University of Brasov
Published: February 2022

Upper gastrointestinal bleedings are still a challenge for gastroenterologists as well as for physicians in the emergency departments. They are one of the most frequent causes for admission in the world. As a result, numerous risk assessment scores were described, some including accessible variables, some others including the need for upper gastrointestinal endoscopy to quantify the risk of mortality, the implementation of emergency endoscopy, the risk of rebleeding, and the necessity of blood transfusion.
CHILAIDITI SYNDROME IN A 49-YEAR-OLD MALE WITH COVID-19 INFECTION – CASE REPORT
Authors:   Faculty of Medicine, TransilvaniaUniversity of Braşov, Manea R.M , Hogea M.D. ,   Clinical Emergency County Hospital of Brașov, Popa R.M ,   Clinical Emergency County Hospital of Brașov, Szasz A.C. ,   Clinical Emergency County Hospital of Brașov
Published: February 2022

The authors illustrate a case of a 49-year-old male patient admitted to our Emergency Department with dry persistent cough, fever, chills, vague abdominal discomfort and a recent history of dyspnoea and fatigability, symptoms suggestive of COVID-19 infection. Physical examination showed mild abdominal distension and no signs of peritoneal irritation. The patient was tested positive for COVID-19 and d-dimers were also found positive, raising a strong suspicion diagnosis of pulmonary thromboembolism as a complication of SARS-COV-2 infection, which required an immediate CT scan. No signs of pulmonary thromboembolism were present on the CT scan. Apart from bilateral pulmonary condensation areas having a ground glass pattern with a peripheral distribution, which are the characteristic radiologic feature of SARS-COV-2 infection, the CT scan also revealed the anterior interposition of the colon between the liver and diaphragm, this being highly suggestive for Chilaiditi Syndrome.
BULLOUS SUBACUTE CUTANEOUS LUPUS ERYTHEMATOSUS. A CASE REPORT
Authors:   Dermatology  Department,  Faculty  of  Medicine,  University  of  Medicine,  Pharmacy,  Sciences  and Technology ‘’G.E. Palade’’ of Targu Mures, Romania, BADEA Mihail-Alexandru
Published: February 2022

Lupus erythematosus is an autoimmune collagen disorder with multiple organs involvement. Subacute cutaneous lupus erythematosus represents about 10% of Lupus erythematosus cases and is frequently drug induced. A 83-year-old female patient, otherwise healthy, presented for disseminated annular lesions with mild pruritus lasting for 5 days.The patient denied any new drug usage in the last two months.Laboratory findings showed raised Anti-Ro antibodies and Anti-La (SS-B). The patient received systemic corticotherapy with the remission of the lesions in one month.Subacute cutaneous lupus erythematosus can present with bullous skin lesions and can arise in elderly people without drug usage.
Electronics in Music: Preliminary Stages
Authors:   The National University of Music Bucharest, Romania, Vlad Radu
Published: February 2022

With a first recorded appearance dating around the 1950s, electronic music – the fruit of rigorous and tenacious labour by acoustician-researchers and composers who tried and succeeded in imposing a new sound-universe – channelled the evolution of the art of sounds as nothing before it. Prominent composers of the orientation – Pierre Schaeffer, Pierre Henry, Edgar Varèse, Herbert Eimert, Karlheinz Stockhausen, Vladimir Ussachevsky, Luigi Nono – had a determinant role in the way music expanded. The literature mentions as early as the beginning of the 20th century the existence of creators with a true calling for identifying original solutions to permanently transform music, breaking its barriers and thus allowing it to develop, expression-wise, in a variety of directions.
European Diplomacy and the Principles of Public International Law applied during the Congress of Berlin 1878
Authors:   Transilvania University of Brasov, Romania, Murzea Cristinel Ioan
Published: February 2022

During this historical time, Romanian diplomacy followed the stable line of the national party who aimed to create a young national state and obtain state independence; this was the main state goal. Considering these major objectives, the deciding parties acted in the spirit of public international law in order to secure Romania’s acknowledgement as an independent nation with a well-deserved role among all other independent countries. As a result of the diplomatic efforts which preceded the Congress of Berlin, Romanian diplomacy obtained the acknowledgement of the legitimacy of Romania from all major powers, so as to obtain the statute of sovereign and independent country.
ANALISIS PENGARUH PERKEMBANGAN TEKNOLOGI PERTANIAN DI ERA REVOLUSI INDUSTRI 4.0 TERHADAP HASIL PRODUKSI PADI
Authors: Febrianti Vini Putri , Permata Tasya Alya , Humairoh Mamai , Putri Odita Mulyana , Amelia Lisa , Fatimah Shaynen , Khastini Rida Oktorida
Published: February 2022

Penelitian ini memuat mengenai perkembangan revolusi industri. Jurnal ini dibahas mengenai faktor-faktor yang mempengaruhi perkembangan revolusi industri, dan pengaruh dari hasil produksi padi dengan tingkat penerapan teknologi PTT dan SRI. Tujuan dari penelitian ini yaitu untuk mendeskripsikan dan mengetahui pengaruh perkembangan revolusi industri. Penelitian ini menggunakan salah satu metode pendekatan yaitu kualitatif deskristif, yang memiliki tujuan untuk mengetahui nilai variabel, tanpa menciptakan, membandingkan, dan mencari hubungannya. Pengambilan sampel yang dilakukan pada penelitian ini dengan cara purposive sample. Purposive sampel adalah pengambilan sampel dengan memberikan ciri-ciri khusus yang sesuai dengan tujuan penelitian. Hasil penelitian memperlihatkan faktor yang paling besar dalam mempengaruhi kehidupan masyarakat adalah perkembangan teknologi. Teknologi yang digunakan untuk mengetahui tingkat penerapan yang dilakukan pada penelitian ini yaitu teknologi dengan metode PTT dan metode SRI. Hasil dari keduanya sangat berbeda, dimana metode PTT lebih mampu memberikan hasil yang lebih unggul. Pada data tercatat bahwa metode SRI dalam kurun waktu tertentu mengalami penurunan dari musim ke musim.
THE DEVELOPMENT OF AL-QIRᾹ’ᾹT AL-SAB' LEARNING METHOD BY QᾹRI’S IN LANGSA CITY
Authors: Fauziah Cut , Wahid Fatin Nabilah
Published: February 2022

The development of al-qirā’āt al-sab' is an activity that is necessarily conducted by every qirā’ah teacher (qāri'). It is essential to transfer the correct readings according to the provisions recommended in Islamic law. Therefore the development of al-qirā’āt al-sab' must be encouraged in the Langsa City community. The purpose of this study was to see the qirā'ah (qāri') teachers in developing the al-qirā'āt al-sab' learning method in Langsa City. By conducting interviews with qirā'āt teachers in Langsa City and using qualitative data analysis, it shows that the qāri's develop al-qirā’āt al-sab' by holding al-qirā’āt al-sab' learning in their respective homes. The methods used are bi al-ifrād, Jibrīl, Talaqqī, and bi al-jamā' with practical learning models. The community's positive responses to al-qirā’āt al-sab' learning activities help them to learn al-qirā’āt al-sab,' while the negative ones are they felt prestige or embarrassed and thought it was unimportant to participate in this activity.
Sexueller Missbrauch von Kindern: historische Aspekte, rechtliche und Schädigung der kindlichen Entwicklung
Authors: Gonçalves Natamy de Almeida , Dias Camila Santos
Published: February 2022

Da es sich um eine Gewalt handelt, die im Laufe der Geschichte mehrere Kinder und Jugendliche auf der Welt plagt, erfordert sexueller Missbrauch von Kindern besondere Aufmerksamkeit, da es sich um ein komplexes Phänomen handelt, das in vielen Fällen schwer zu identifizieren ist, da der Täter in der Regel eine Vertrauensperson der Familie ist und von der erwartet wird, dass sie sich um das Opfer kümmert. als leibliche Eltern, Stiefväter, Onkel oder enge Freunde zum Beispiel. Darüber hinaus treten die meisten Fälle von sexuellem Missbrauch in der eigenen Wohnung des Opfers auf, wo wenig von dem Kind und Jugendlichen erwartet wird, dass sie sich in einer verletzlichen Situation befinden. Basierend auf den beschriebenen Faktoren stellt diese Forschung die folgende Leitfrage: Was ist sexueller Missbrauch und welche Auswirkungen hat dies auf die Entwicklung des Kindes? Dieser Artikel zielte darauf ab, die historischen und rechtlichen Aspekte des sexuellen Missbrauchs zu untersuchen, die Komplexität seiner Definitionen zu untersuchen und die möglichen Auswirkungen auf das Opfer darzustellen. Zu diesem Zweck wurde eine bibliographische Überprüfung des qualitativen, beschreibenden und explorativen Charakters vorgenommen, die Überlegungen zum Thema anregen. Es wurde festgestellt, dass das Kind und der Jugendliche nicht immer rechtliche Unterstützung hatten, nachdem sie mehrere Gewalt erlitten hatten, ohne dass ihre Angreifer gebührend bestraft wurden. Im Laufe der Zeit wurden Gesetze eingeführt, und in Brasilien hatte das Statut der Kinder und Jugendlichen (ECA) eine Zeit der Festlegung der Rechte von Kindheit und Jugend markiert und Schutzmechanismen eingeführt, auch gegen Gewalt wie sexuellen Missbrauch. Schließlich wurde in dieser Studie berücksichtigt, dass es an Informationen für die Bevölkerung zu diesem Thema mangelt, was die Reproduktion des oben genannten Vergehens bestätigt. Es wurde beobachtet, dass unter Berücksichtigung der Schädigung der biopsychosozialen Gesundheit des Opfers und seiner Familie Studien und Präventionsprojekte durchgeführt und verschiedene Formen der Meldung dieses Verbrechens eingeführt wurden. Es wurde der Schluss gezogen, dass Strategien zur Vorbereitung von Familien, Fachkräften und Institutionen, die für die Gewährleistung der Rechte von Kindern und Jugendlichen verantwortlich sind, so vorbereitet werden müssen, dass sie zur Stärkung des Kampfes gegen sexuellen Missbrauch beitragen können.
The The Chemical Characteristic of Manila Duck Sausage Processed by Using Purple Sweet Potato Flour as Subtitute of Tapioca
Authors: Noach Yakob Robert , Kehik Agatha Feriyanti Fore , Sipahelut Gertruida Margareth
Published: February 2022

Experiment aims to determine the substitution effect of tapioca by purple sweet potato flour on antioxidant, fat oxidation, fat content and pH of Manila duck sausage. Completely randomised design with 5 treatments and 3 replications was applied in this experiment. Those treatment were:  P0 = 100% of tapioca; P1 = 25% purple sweet potato flour + 75% tapioca; P2 = 50% purple sweet potato flour + 50% tapioca; P3 = 75% purple sweet potato flour + 25% tapioca; dan P4 = 100% purple sweet potato flour. Variable measured were: antioxidant, fat oxidation, fat content and pH. The result showed that treatments have close significant (P<0.01) on antioxidant and fat oxidation, significant (P<0.05) on pH and no significant (P>0.05) on fat content.  It can be concluded that insreasing of purple sweet potato flour substitution up to 100%, producing the best chemicals characteristic of Manila duck sausage which indicated by increase of antioxidant, decreasing of fat oxidation, lower fat content and pH of sausage.
Badanie efektów wdrożenia zintegrowanego systemu zarządzania jakością zgodnego z ISO 9001 i ISO 14001
Authors: Mazurkiewicz Jacek , Mendzik Marzena , Kliś Janusz
Published: February 2022

Celem opracowania jest prezentacja i ocena zmian powstałych w wyniku wprowadzenia wspólnego dla 4 oddziałów zakładu zintegrowanego systemu zarządzania jakością oraz elektronicznego przesyłu dokumentów. Do badań wykorzystano ankiety, których uzupełnieniem była analiza dokumentacji źródłowej, wywiady z pracownikami, ocena korzyści zmian, audyty wewnętrzne.
Twórczość w organizacji uczącej się - imperatyw ciągłej transgresji
Authors: Szwiec Paweł
Published: February 2022

Podjęto próbę syntezy występujących w literaturze definicji organizacji uczącej się poprzez poszukiwanie wspólnych im elementów. Przedstawiono właściwości organizacji uczącej się. Wskazano aktywność twórczą pracowników jako warunek sprawnego funkcjonowania organizacji uczącej się. Przybliżono właściwości organizacji uczącej się i organizacji twórczej.
Przedsiębiorczość wewnętrzna
Authors: Laszuk Marek
Published: February 2022

Przybliżono zagadnienie intra przedsiębiorczości. Pod pojęciem tym rozumie się działalność realizowaną wewnątrz istniejącej struktury organizacyjnej, będącą odpowiedzią na biurokratyczne skostnienie organizacji, umożliwiającą rozwój kreatywności i innowacyjności. Intra przedsiębiorca to wewnątrzkorporacyjny przedsiębiorca. Jest to osoba pracująca w dużej korporacji, która bierze na siebie bezpośrednią odpowiedzialność za obrócenie pomysłu w zyskowny produkt poprzez minimalizację ryzyka i innowacje.
Natura problemów marketingowych
Authors: Frąckiewicz Ewa
Published: February 2022

Omówiono zagadnienie ryzyka i niepewności decyzji marketingowych. Dokonano charakterystyki problemów marketingowych. Przedstawiono rolę informacji w podejmowaniu decyzji marketingowych.
Wybrane czynniki finansowe w funkcjonowaniu przedsiębiorstw w środkowowschodniej Polsce
Authors: Łęczycki Kazimierz
Published: February 2022

Podstawowym warunkiem prowadzenia działalności gospodarczej jest posiadanie przez przedsiębiorstwo określonych zasobów rzeczowych. Niezbędne jest także określenie sposobów ich pozyskiwania, które wymagają finansowania przy użyciu kapitału własnego lub obcego. Przeprowadzone badania jednoznacznie wykazały, że czynniki finansowe stanowią istotny problem w działalności gospodarczej przedsiębiorstw.
Analiza potrzeb szkoleniowych małych organizacji w zakresie systemów zarządzania jakością
Authors: Grudowski Piotr
Published: February 2022

Artykuł przedstawia wybrane wyniki badań, których celem była identyfikacja problemów i oczekiwań małych organizacji wdrażających systemy jakości. W następstwie tych badań przeprowadzono analizę statystyczną ustalającą związek elementów podejścia procesowego z systemami jakości małych organizacji oraz postrzeganie wpływu tego podejścia na zadowolenie klientów.
Wpływ kondycji przedsiębiorstwa na decyzje o uchylaniu się od podatków
Authors: Zbroińska Barbara
Published: February 2022

Celem opracowania jest zbadanie, w jakim stopniu kondycja finansowa przedsiębiorstwa przyczynia się do ukrywania rzeczywistych rozmiarów działalności przed organami skarbowymi. Przedmiotem badań jest obciążenie podatkiem dochodowym. Próbę badawczą stanowią 42 przedsiębiorstwa różnej wielkości i formy prawnej, którym organ skarbowy udowodnił zaniżenie dochodu lub zawyżenie straty, a w konsekwencji zmniejszenie zobowiązania podatkowego.
Wdrożenie i stosowanie controllingu a kształt struktury organizacyjnej przedsiębiorstwa
Authors: Lichtarski JanuszMarek
Published: February 2022

Celem opracowania jest prezentacja fragmentów wyników badań empirycznych, poświęconych identyfikacji zmian struktury organizacyjnej przedsiębiorstwa związanych z wdrożeniem i stosowaniem controllingu w przedsiębiorstwie. Podstawą prezentowanych rozważań jest krajowa i zagraniczna literatura przedmiotu oraz wyniki badań empirycznych przeprowadzonych w 2004 roku w 56 dolnośląskich przedsiębiorstwach.
Zasada preferencji zadań mierzalnych, czyli dlaczego organizacje bywają na ogół bardziej trywialne w rzeczywistości niż w teorii
Authors: Łobos Krzysztof
Published: February 2022

Celem artykułu jest ukazanie zasady preferencji zadań mierzalnych, którą można uznać za powszechnie przyjmowaną i z bardzo dużym prawdopodobieństwem realizującą się w praktyce. Omówiono organizacyjne implikacje tej zasady oraz ograniczenia jej stosowania. Podjęto próbę odpowiedzi na pytanie, czy działania bez mierzalnych efektów, w tym miękkie metody i techniki mają w ogóle jakiś sens?
Internet jako narzędzie pracobiorcy na rynku pracy
Authors: Jarecki Wojciech
Published: February 2022

W artykule podjęto problem wykorzystania Internetu jako narzędzia mogącego przyczynić się do polepszenia sytuacji pracobiorców na rynku pracy. Postawiono tezę, że w Polsce niedostatecznie wykorzystuje się Internet do tego celu. Przeprowadzono analizę porównawczą między Polską i innymi krajami europejskimi, głównie Unii Europejskiej w zakresie wielkości bezrobocia, dostępu do Internetu i częstości korzystania z tego narzędzia przez pracobiorców, stopnia wykorzystywania Internetu do kształcenia formalnego, nieformalnego i do polepszania bieżącej sytuacji na rynku pracy. Dane zaczerpnięto z Eurostatu. Dotyczą one grupy szczególnie dotkniętej bezrobociem - osób w wieku 15-24 lata.
Wpływ mediów na powstawanie kosztów transakcyjnych
Authors: Glinka Beata , Pasieczny Jacek
Published: February 2022

Wpływ mediów na powstawanie kosztów transakcyjnych
Kreacja wartości na Giełdzie Papierów Wartościowych w Warszawie
Authors: Cwynar Andrzej , Cwynar Wiktor
Published: February 2022

Kreacja wartości na Giełdzie Papierów Wartościowych w Warszawie
System HACCP w przedsiębiorstwie
Authors: Fajczak-Kowalska Anita
Published: February 2022

System HACCP w przedsiębiorstwie
Six Sigma a kultura organizacyjna
Authors: Kamiński Robert
Published: February 2022

W artykule podjęto próbę określenia rodzaju kultury organizacyjnej będącej podstawą dla wprowadzenia i funkcjonowania programu jakości Six Sigma. Wykazano, że kulturą tą będzie otwarta kultura organizacyjna. Ma ona znaczenie w realizacji takich elementów programu Six Sigma jak: orientacja na proces, pomiary, demaskowanie błędów i koncentracja na usuwaniu długotrwałych problemów.
Kształcenie w firmie międzykulturowej
Authors: Niemiec Andrzej
Published: February 2022

Szkolenie pracowników w międzynarodowych firmach wiąże się z rozszerzeniem metod pedagogicznych, które oprócz nowych środków i zdobyczy psychologii muszą być daleko bardziej otwarte na różnorodność wielu kultur tworzących jedną organizację. Powiększające się zasoby wiedzy oraz prędkość zdobywania informacji powodują konieczność szukania efektywnych sposobów przekazywania wiedzy.
Facility Management jako strukturalne wsparcie koncepcji outsourcingu i Lean Enterprise
Authors: Kądziela Sławomir
Published: February 2022

Artykuł wskazuje korzyści z zastosowania koncepcji Facility Management (czyli zarządzania działalnością pomocniczą). Jest to koncepcja wspierająca elastyczność organizacji przemysłowych i usługowych, wykorzystująca zalety outsourcingu i Lean Enterprise/Lean Management.
Organizacja współczesnych systemów wytwarzania
Authors: Mazur Zygmunt
Published: February 2022

Artykuł mówi o roli zarządzania produkcją w zarządzaniu organizacją, a także o procesach w systemie wytwarzania: procesach podstawowych, przygotowania oraz pomocniczych. Ich celem jest tworzenie produktów wysokiej jakości, we właściwym czasie, minimalnym kosztem. Autor artykułu przedstawia również nowoczesne systemy wytwarzania, które powinny posiadać zdolność adaptacyjną w stosunku do zmian zewnętrznych i wewnętrznych oraz wysoką elastyczność. Orientacja na procesy pozwala zatem na efektywniejsze zarządzanie systemem produkcyjnym.
Bezpośrednie inwestycje zagraniczne w województwach lubelskim i podkarpackim w kontekście uwarunkowań geopolitycznych
Authors: Bojar Ewa , Bis Jakub
Published: February 2022

Położenie na mapie Polski i Europy województw lubelskiego i podkarpackiego ma niewątpliwie strategiczne znaczenie dla ich przyszłości. Artykuł przedstawia udział na tle całego kraju inwestycji zagranicznych w tych regionach, ich strukturę, ilość, a także omawia czynniki utrudniające inwestowanie w tych województwach. "Pomarańczowa rewolucja" stworzyła szansę dla rodzimego biznesu na nawiązanie współpracy i rozszerzenie swojej działalności na Ukrainie.
GENDER VARIATIONS FAVOURING MALE STUDENTS IN PERCEIVED NATURE OF LEARNING MOLE CONCEPT
Authors: Adu-Gyamfi Kenneth , Elikem Vorsah Rejoice
Published: February 2022

A good number of instructional strategies are identified to help students overcome their learning difficulties in the mole concept. However, Ghanaian senior high school students continue to have difficulties in the mole concept. Hence, there was the need to examine the perceived nature of learning the mole concept in the perspectives of male and female students. An explanatory sequential mixed methods design was adopted to collect quantitative and qualitative data. The students, selected through a multistage sampling procedure from four schools, responded to questionnaire and interview guide. Through independent-samples t-test statistics it was established that though students were full of uncertainty about the perceived nature of the mole concept that of males differed from their female counterparts. Hence, chemistry teachers should create learning environment conducive enough for male and female students to overcome their uncertainty in the mole concept.
Keywords: chemistry teachers, gender variations, learning mole concept, perceived nature
Mesenchymal Stem Cells Combined with Bovine Colostrum Decrease the PDGF and Fibrosis Level after Hepatectomy in Liver Fibrosis Rats Model
Authors: Fuadi Ahmad Fathi , Riwanto Ignatius , Putra Agung , Prabowo Erik , Istiadi Hermawan
Published: February 2022

Introduction: Liver fibrosis is a healing response of the liver to injury by depositing excessive extracellular matrix proteins. Although this fibrosis has a strong impact on survival following resection, there is no therapeutic guideline so far for liver fibrosis. Platelet-derived Growth Factor (PDGF) is the most potent mitogen of Hepatic Stellate Cells (HSC) which started liver fibrogenesis. Mesenchymal Stem Cells (MSCs) have an anti-fibrotic effect by controlling inflammation and HSC immunomodulation, while Bovine Colostrum (BC) has an antifibrotic effect by its antioxidant capacity and growth factor content. However, their effect was only studied in the non-resected fibrotic liver and their combination is never been studied. our study aimed to examine the effects of MSC, BC and their combination on PDGF and fibrosis level in the fibrotic liver after resection.
Material and methods: Twenty-five Sprague-Dawley rats with fibrotic liver were randomly assigned to BC, MSC, MSC+BC, control, and sham groups. Hepatectomy 50% was carried out except for the sham group. The 106MSCs were given intraparenchymal liver, while BC (15 μL/g) was given orally for 5 days/week until day 10. The PDGF plasma level was assessed on days 3, 7, and 10. The histopathologic examination of the liver remnant was done on day 10 using Metavir Scoring System.
Result: MSC+BC significantly increased PDGF level on day 3 followed by a significant decrease on day 10 (p<0.001). The Metavir mean score was 1.2 in the MSC+BC group.
Conclusion: MSC+BC combination can improve liver fibrosis after hepatectomy of liver fibrosis rats by preventing post-hepatectomy fibrogenesis.
Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 262-270
“H1N1 influenza revisited: Our experience of the 2019 outbreak”
Authors: Hegde Swati , Thyagaraj Vijayashree , Prabhu Divya
Published: February 2022

Background: The first case of H1N1 influenza was reported in India in 2009. A decade later it continues to jeopardize India’s healthcare infrastructure. There is voluminous data available regarding the 2009 Swine flu pandemic. This study aimed to outline the clinico-laboratory profile and outcome of patients in the recent 2019 H1N1 outbreak and compare these parameters between survivors and non-survivors.
Methods: This was a retrospective descriptive study of the clinico-laboratory parameters of patients hospitalized with H1N1 influenza from October 2018 to September 2019 in a tertiary care hospital in South India.
Results and Discussion: Of the 121 patients included, 110 were survivors and 11 non- survivors with 9% mortality. Fever (97%) was the commonest complaint followed by cough (92%) and breathing difficulty (38%). At admission tachypnea and low saturation was common among the non-survivors and was statistically significant when compared tosurvivors. Presence of bibasal or diffuse crepitations on lung auscultation was associated with poor outcome. On chest radiographs, lower zones appeared commonly affected, and involvement of bilateral mid zone and lower zone (36.4%) was significantly higher in the non-survivors’ group.
Conclusion: Our findings summarized that respiratory rate, finger pulse oximetry, and chest radiograph remain a valuable tool in identifying high risk patients. Although the mortality rate associated with H1N1 is decreasing, there is speculation aplenty whether this contagious illness has already been conquered or not.
Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 426-431
A case of Peritonitis with pneumoperitoneum secondary to a spontaneous rupture of splenic abscess
Authors: Hajri Mohamed , Talbi Ghofrane , Bacha Dhouha , Ferjaoui Wael , Gharbi Lassad , Khalfallah Mohamed Taher
Published: February 2022

Sponteous rupture of a splenic abscess is rare and little described in the literature. It can cause peritonitis with pneumoperitoneum. Our case illustrates this exceptional complication in a 77 year-old diabetic patient who consulted for abdominal pain with asthenia. The abdominal computed tomography showed an acute peritonitis caused by with splenic abscess. Aeoporty was also observed. He was operated but died postoperatively for severe sepsis. Our case is rare and interesting. Indeed, a splenic abscess can be the cause of peritonitis, pneumoperitoneum and aeorportie.
Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 455-457
Removal of rubber earphonecover inside nose after 2 years in a general practitioner setting during covid-19 pandemic
Authors: Zainun Zuraida , Hadi Azliehanis Abd
Published: February 2022

Inserted a big size of rubber ear phone cover into the nose is a rare case.Foreign body regarding children is common and need to be seriously considered.Nowadays, using an earphone for music players and games isverycommon among children that need to be more cautious.In general practitioner’s practice, several limitations seen with no fully equipped and emergency trolley, no general anaesthetic set up and no X ray. In this case report, we reported a 10-year-old child with bad smelling breath for 2 years with on and off pain and difficulty in breathing. It has become worsened until the child informshis mother regarding this incidence last weeks. Last 2 weeks, the child was examined in dental clinic for this bad smelling breath and no dental problem identify. The parents were refused to bring the child to the hospital because of this Covid-19 situation worsening in this state currently. They decided to cometo nearby general practitioner where the smelly and soaked with pus in this ear was removed without any complication in that clinic without any anaesthesia using blunt crocodile forceps.
Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 467-469
Synthesis and Action of N-acylphenylacetamides and N-acyl-β-ketoamides on the Central Nervous System
Authors: Kodonidi I. P. , Anenko D. S. , Pozdnyakov D. I.
Published: February 2022

Introduction. One of the most promising directions in the search for biologically active compounds is the molecular design of biologically active compounds containing a known pharmacoform fragment. In this article, phenylacetic acid derivatives are considered as a scaffold for the search for biologically active compounds. However, the phenylacetamide derivative is of particular interest, its fragment is included in the structure of the atenolol drug. Optimization of methods for the synthesis of N-acylphenylacetamides and N-acyl-β-ketoamides will expand the boundaries of molecular design and targeted synthesis of biologically active substances containing a phenylacetic acid fragment as a centroid.

Aim. Obtain N-acylphenylacetamides and N-acyl-β-ketoamides, optimize the synthesis and isolation methods, and establish the degree of manifestation of the psychotropic activity of the compounds.

Materials and methods. Obtaining the target N-acylphenylacetamides was carried out by the interaction of 2-phenylacetamide with carboxylic acid anhydrides under conditions of acid catalysis. The next stage of the synthesis was the preparation of N-acyl-β-ketoamides by the interaction of the synthesized N-acylphenylacetamides with carboxylic acid anhydrides in the proposed catalyst for boron trifluoride diacetate. The structure of the compounds was confirmed by IR, 1H NMR spectrometry. The individuality and purity of the obtained compounds were monitored by thin layer chromatography. The study of the synthesized compounds on the central nervous system was carried out in the tests "Conditioned reflex of passive avoidance – CPAR", "Extrapolation escape (ETI)", "Morris water maze" and "Beam Walking".

Results and discussion. As a result of the research, N-acylphenylacetamides and N-acyl-β-ketoamides were synthesized. The essence of the optimization of the procedure for the synthesis of N-acylphenylacetamides is to replace chloric 65 % with concentrated sulfuric acid. The 1H NMR spectra confirming the structures of the synthesized compounds revealed important characteristic features for N-acetyl-3-oxo-2- phenylpentanamide (VI) and N-acetyl-3-oxo-2-phenylhexanamide (VIII) containing a chiral center. The resulting substances have a pronounced effect on the central nervous system, their nootropic activity is to reduce the severity of sensorimotor disorders in animals. As a result of the study, the leading compounds were identified, superior to the effect of the reference drug piracetam.

Conclusion. The carried out research confirms the expediency of searching for highly effective and safe nootropic agents in the series of acylated derivatives of phenylacetic acid amide.
Measles Virus as a Vector Platform for Glioblastoma Immunotherapy (Review)
Authors: Nikolaeva E. Yu. , Shchetinina Yu. R. , Shokhin I. E. , Zverev V. V. , Svitich O. A. , Susova O. Yu. , Mitrofanov A. A. , Ammour Yu. I.
Published: February 2022

Introduction. Oncolytic virotherapy is one of the approaches in immunotherapy of solid brain tumors. Measles virus vaccine strains are prospective agents for the therapy of cancers such as neuroblastoma, mesothelioma, and glioblastoma multiforme. The hyperexpression of the CD46 and other receptors on the surface of malignant cells allows the measles virus to infect and lyse the tumor, thus inducing an immune response. However, widespread immunization of the population and the resistance of neoplasms to oncolysis present difficulties in clinical practice.

Text. This review covers approaches to modifying the measles virus genome in order to increase specificity of virotherapy, overcome existing immunity, and enhance the oncolytic effect. It was shown that expression of proinflammatory cytokines on viral particles leads to tumor regression in mice and triggers a T-cell response. Several approaches have been used to overcome virus-neutralizing antibodies: shielding viral particles, using host cells, and altering the epitope of the protein that enables entry of the virus into the cell. Furthermore, the insertion of reporter genes allows the infection of target cells to be monitored in vivo. A combination with the latest immunotherapies, such as immune checkpoint inhibitors, demonstrates synergistic effects, which suggests the successful use of combined approaches in the therapy of refractory tumors.

Conclusion. Measles virus attenuated strains appear to be an easy-to-modify and reliable platform for the therapy of solid brain tumors.