bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing Supplementary Books on Mangroves in Aceh Tamiang for Biology Students
Authors: Asyari Humairoh , Sudibyo Mufti , Djulia Ely
Published: April 2024

This study aimed to produce supplementary books on mangroves in Aceh Tamiang for undergraduate students in the Ecology course. Research and Development (R&D) adapted from the Thiagarajan (4D) model consisting of defining, designing, developing and disseminating stages were used. Field research was employed to develop the product. Material expert lecturers, learning design experts, and layout design experts validated the supplement book developed. Ecology lecturers and students of the Biology department at the State University of Medan assessed it. The results of the assessment by the material experts had a mean score of 86.6% in the very good/feasible category. Meanwhile, learning design experts had a mean score of 93.2% in the very good/feasible category. Likewise, the layout design experts had a mean score of 91.3% in the very good/feasible category. Responses towards the books by lecturers had a high very good/feasible category with an overall percentage of 90.26%. The students’ results based on individual, small group and limited field tests obtained the mean scores of 97.9%, 89% and 90.95%, respectively, in the very good/feasible category. These results indicated that the supplementary books that have been developed were very good/feasible. This product’s effectiveness could be seen from the gain score of 0.52 in the moderate category and the results of the Wilcoxon test t-count 0.000 < t-table 0.05. It can be concluded that using the supplement books effectively increases students’ knowledge of mangrove ecosystems with significant differences in pretest and posttest scores so that supplement books can be used as additional teaching materials for lecturers, students and readers.
Keywords: supplementary books, mangroves, ecology course
Enhancing Scientific Argumentation Skills Through Electronic Worksheets Based on Research Oriented Collaborative Inquiry Learning
Authors: Rizqi Nurul Laily Tsaniyatur , Rohaeti Eli
Published: April 2024

This study aimed to develop and determine the feasibility of an electronic worksheet based on Research Oriented Collaborative Inquiry Learning in a course on chemical equilibrium. The development model of this research was Research and Development. It follows the 4D model by Thiagarajan. The 4D development model consists of four research and development steps: define, design, develop and disseminate. The instruments in this study were questionnaires used to obtain input data for products and quantitative scores as the value of media feasibility. The results showed that the components of the e-worksheet on the aspects of the materials, learning, visual display, and software engineering were suitable for use by students. The percentage of assessment by chemistry teachers was 92.50%, peer reviewers were 90%, and students’ rating was 87%. Therefore, the electronic worksheet based on Research Oriented Collaborative Inquiry Learning (REORCILEA) is worthy of being used as a learning medium in the course on chemical equilibrium to improve scientific argumentation skills. The electronic worksheet has the advantage of being more practical and effective in learning.
Keywords: electronic worksheet, collaborative inquiry learning, chemical equilibrium
Making an Android-Based Interactive E-Module on Reaction Rates Learning Material Integrated with Islamic Values
Authors: Sari Sari , Salman Abdul Fatah M , Zenab Subarkah Cucu
Published: April 2024

The research was motivated by the importance of Android-based interactive learning media and integrated 21st-century Islamic values. This study aimed to develop an Android-based interactive e-module learning media on the learning materials about chemical reaction rate integrated with Islamic values, analyze the results of the validation test, and determine media feasibility. The research method was Research and Development (R&D) with the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). The e-module display consisted of five main menus: introduction, material, discussion, quiz, and profile. The e-module presented material on the topic of reaction rates with pictures, animations, videos and Islamic values related to the concepts and factors that affect reaction rates. Then, the user had to follow the discussion and complete a quiz to test their understanding. Research data information could be seen on the profile menu. The results of the validation test obtained an average percentage value of 87.13%. The results of the feasibility test obtained an average percentage value of 86.3%. So, this e-module is suitable for use in the learning process.
Keywords: android-based interactive learning, media, 21st-century, Islamic values
A Framework Design for Developing and Validating Virtual Test to Assess Science Process Skills in Chemistry
Authors: Amali Nurul , . Nahadi , Firman Harry
Published: April 2024

Technological advancements and the demands of the pandemic around the world forced educators to think of solutions in the teaching and learning process so that there were no obstacles in the assessment process. Although the focus of learning assessment in Indonesia focused on literacy and numeracy assessment, the assessment of science process skills is still carried out because the science process skills are the core key to developing children’s knowledge in science, including chemistry. The present assessment process used more online platforms or virtual tests. This study aimed to describe the virtual test design framework that is suitable for assessing science process skills in chemistry. The method used was a literature review. We collected journal articles in accordance with the theme, and then the journal article was reviewed and arranged into several discussion sections. The framework design for developing and validating virtual test had four phases: planning, developing, validating, trial and data processing. Discussions include an overview of virtual tests, assessing the skills of chemical-specific science processes with virtual tests and how the virtual test design framework assesses science process skills on chemistry that qualify on assessment characteristics (validation, reliability, objectivity, and practicality).
Keywords: assessment, virtual test, science process skills
Framework for Implementing e-Portfolio Assessment to Improve Student Habits of Mind and Mastery of Chemistry Studies Concepts
Authors: Mahardika Ilham , . Nahadi , Firman Harry
Published: April 2024

The COVID-19 pandemic emphasized the need for improving teachers’ online teaching skills. One skill was using electronic portfolio assessment. Electronic portfolio assessment as an alternative assessment does not only focus on cognitive aspects but also is in line with the regulations of the Ministry of Education regarding the assessment of learning outcomes that focus not only on cognitive aspects but also on aspects of skills and attitudes. This study aimed to develop a framework for electronic portfolio assessment to improve students’ habits of mind and mastery of chemical studies concepts. We conducted a literature review to identify, categorize, synthesize and develop a framwork. This offers chemistry teachers a model for systematically designing and implementing an electronic portfolio of assessments and provides them with the instruments to conduct further research on assessment techniques. This framework guides chemistry teachers through important technical decisions, such as setting goals, identifying clear goals and establishing meaningful criteria for electronic portfolio assessment. Other issues discussed include defining the content of the electronic portfolio, managing the electronic portfolio, and monitoring and evaluating processes.
Keywords: electronic portfolio assessment, habits, chemical concepts
Development and Validation of a Virtual Test Based on Three Level Chemical Representation to Measure Student Understanding of Hydrolysis of Salt
Authors: Mayangsari Dian , . Nahadi , Firman Harry
Published: April 2024

This study aimed to develop and validate virtual tests based on three levels of chemical representation that can measure students’ understanding of salt hydrolysis. This study used development and validation methods, which consisted of 4 phases. First, the determination of the purpose and the scope of the test. Second, the development and design of the test Third. The validation, selection of items and scoring guidelines. Lastly, the assembly and evaluation of the test. The instruments used were a content validation sheet for experts to judge and an interview sheet for students. The participants were 11th grade senior high school students from three different schools in Karawang with 60 total respondents, and six of them were interviewed. The results showed that the virtual test containing 33 multiple choice items was valid with the Content Validity Index (CVI) value for macroscopic, submicroscopic, and symbolic level items being 1. The Virtual test was also reliable, with Cronbach’s alpha value for macroscopic, submicroscopic, and symbolic level items, respectively, being 0.605, 0.614 and 0.644. The results of this research can be used to measure students’ understanding of hydrolysis of salt based on three-level chemical representation.
Keywords: virtual tests, chemical representation, salt hydrolysis
Validity and Reliability Analysis of HOTS Multiple Choice Questions in a Chemistry Course at a Senior High School
Authors: Syafitri Anis , Simorangkir Murniaty , Sudrajat Ajat
Published: April 2024

This study examined the validity and reliability of a newly developed multiple-choice evaluation system that measured students’ higher-order thinking skills (HOTS). The instrument test consisted of 45 multiple-choice items and was developed based on the cognitive domain of Bloom’s Taxonomy. A quantitative method was used. It consisted of three phases: Content Validity by inter-rater agreement, Construct Validity by principal component analysis (PCA), and Reliability shown by Chronbach’s alpha. The content validity by inter-rater agreement found that the instrument was categorized as valid. The construct validity by PCA found that each item in the evaluation instrument measured one-dimensionality, which is good to be used as an evaluation instrument test. The reliability was established to be a high degree with Chronbach’s Alpha being 0.94. From the result of this study, a valid and reliable HOTS multiple-choice item evaluation instrument has been produced and is ready to be tested in a small sample to examine its empirical quality.
Keywords: validity, reliability, multiple-choice, evaluation system
Needs Analysis for the Development of Science e-Modules Assisted with Kvisoft Flipbook Maker on the Basic of Project Based Learning on Heat and Transfer Materials to Improve Creative Thinking Ability in the Pandemic Period
Authors: Fitri Fatimah Nur , . Sarwanto , Yamtinah Sri
Published: April 2024

Creative thinking is a high-order thinking skill that is considered to be an important skill to succeed. Creative thinking abilities include fluency in thinking, flexibility of thinking, originality of thinking, and detailed thinking (elaboration). The lack of teaching materials on the topic of heat transfer and the inability to think creatively about the topic negatively affect students. Therefore, this study aimed to analyze the need for the development of an e-module using the Flipbook Maker application. The need analysis for the e-module was analyzed in line with creative thinking abilities to support online learning. This study used a qualitative method, with the research subjects being teachers and students of grade VII of Junior High School in Sukoharjo. Data collection techniques employed were questionnaires and interviews, in which the data were then analyzed descriptively. The study revealed that students’ creative thinking abilities were still low on indicators of flexibility and originality. For these reasons, project-based learning (PJBL) is a learning model that can be applied to improve students’ creative thinking abilities. In addition, teachers and students need e-modules to support the online learning process. Thus, this research can be elaborated by developing a natural science e-module assisted by a Flipbook Maker based on PJBL to improve students’ creative thinking abilities.
Keywords: Science e-Modules, Project Based Learning, Creative Thinking Ability
Augmented Reality as a Media of Mathematics Learning in the Post-COVID-19 Pandemic
Authors: Rifqi Mahmud Muhammad , Carlian Yayan , Tri Utami Kartika
Published: April 2024

In this era, the development of technology is going quite fast. Smart phones are common to use in every element in society. The usage of technology increased rapidly especially after COVID-19. People have started using gadgets more intensively almost for every activity and working from home is the one of it. The advancement of technology has affected every aspect of human life and one of these is education which should be able to adjust with the development of technology. The new innovation in educational aspect is learning media that should be done. R&D is the method to know how the design that wants to be developed and know the development of augmented reality learning media in elementary school at second-grade mathematics subjects in space shape lesson. As for the result of this research are states that the augmented reality learning media that is developed is worthy and good in both material and media aspects as the solution for today’s learning innovation especially for mathematics subjects in space shape lessons.
Keywords: Augmented Reality, Mathematics Learning, Post-COVID-19
Application of Moodle-based Blended Learning to Improve Students' Critical Thinking Skills in Straight Motion Materials
Authors: Yuniarti Suhendi Herni , Rochman Chaerul , Dwi Putra Rusmawijaya Muhammad
Published: April 2024

The learning applied to the revised 2013 edition of the curriculum requires students to master critical thinking skills. One of the efforts to improve critical thinking skills is by applying blended learning. This study aimed to determine the improvement of critical thinking skills using Moodle-based blended learning. This type of research is a quasi-experiment with a nonequivalent research design. Sampling was done using purposive sampling technique, in order to obtain class X MIPA 4 as the experimental class and X MIPA 5 as the control class at Cisolok, which consists of 60 people, 37 are female and 23 are male. This research instrument uses essay questions to test critical thinking skills in straight-motion material with as many as 10 questions. The results showed an increase in critical thinking skills of experimental class students who obtained an N-gain of 0.60, while an increase in critical thinking skills of control class students obtained an N-gain of 0.56. The results of the hypothetical analysis of t-test using blended learning obtained t count pretest of 1.07 and posttest of 1.53, while t table of -2.048 so that t count > t table and H0 is rejected while Ha is accepted. Thus, it can be concluded that there is an increase in students’ critical thinking skills by applying Moodle-based blended learning on straight motion.
Keywords: moodle-based blended learning, critical thinking skills, straight motion materials
Designing Modeling-based Physics Online Learning Assisted with Home-lab-kit
Authors: Pratidhina Elisabeth , Rosana Dadan , Kuswanto Heru
Published: April 2024

Learning Physics online can lead to issues such as lack of student engagement and limited access to laboratory activities. This work aims to develop modeling-based physics online learning assisted with home-lab-kit to ease up on those problems. Home-lab-kit is an Arduino-based experimental kit delivered to students in advance before class. The learning model was designed by adapting the constructivism paradigm. We designed the learning activity and implemented it in a group of 10 college students majoring in physical education. Using a self-report checklist, we measure students’ engagement before and after the learning process. There is an improvement in students’ engagement with a normalized gain of 0.33, which can be classified as a medium improvement. It shows that the modeling-based physics online learning assisted with home-lab-kit is feasible in keeping the students engaded. In addition, students respond well to the learning model implementation and the supporting materials.
Keywords: modeling-based physics, online learning assisted, home-lab-kit
Developing Diagnostic Test on Geometrical Optics (DT-GO) Concept
Authors: Kunaedi Jajang , Samsudin Achmad , Hasanah Lilik , Hidiana Aminudin Adam , Herliyana Dewi Fanny , Alfionita Umar Fini , Rona Wahyu Astuti Itsna , Nurul Mufida Shobrina
Published: April 2024

Developing Diagnostic Test on Geometrical Optics (DT-GO) ConceptThe purpose of this research is to develop the instrument of diagnostic test on optical geometry material, especially in the mirror and lens topics, as well as to unveil the misconceptions of students at one of the public schools in Subang Regency. A purposive sampling technique sampling with sample selection utilizing cluster random sampling technique was conducted on a total of 96 respondents. The instrument utilized by modifying the Four Tier Diagnostic Test which was developed by Kaltakci- Gurel (2017) is developing diagnostic test on geometrical optics (DT-GO). The results of the instrument analysis on the validity test, reliability test, difficulty level test, and discriminatory power, state that the instrument was very well utilized and developed. Based on data analysis and discussion, it can be concluded that overall misconceptions had occurred of overall misconceptions that occur in students are 42.04 %, thus they meet the requirements for misconceptions to a moderate level.
Keywords: diagnostic test, Geometrical Optics (DT-GO)
Smart Class System Prototyping through Sustainable Infrastructure Based on Mobile Application SPACE (Smart Program - Class Architecture) Integrated Smart Building Management System
Authors: Latiefatul Millah Roprop , Ilham Fadhlurrahman Muhammad , Denya Agustina Rena
Published: April 2024

Optimizing innovation in the use of health technology in infrastructure will directly impact the conditions of social interaction in the community, including within the scope of the school area. The Smart Class concept collaborates with learning carried out in a hybrid way. However, it is not yet fully optimized by digitizing the existing infrastructure with the concept of managing school facilities and infrastructure. The implementation of the Smart Class uses the intelligent building management system (IBMS), where this system integrates all parts of the building with the Internet of Things (IoT), facilities, and infrastructure and can minimize pandemic transmission in the academic sphere by accessing via mobile app. This research aims to analyze the design of the smart program class architecture integrated monitoring system to implement IoT-integrated health protocols, especially in the middle school scope. This research uses qualitative and quantitative methods with descriptive analysis through the development of user research at the system design stage. The output of this innovation is how schools implement digital technology comprehensively, starting from the application of IoT, sensors, and databases in a real-time mobile app environment. There are three main things: the data input, data processing, and output value. The intervention of school needs can be expanded with the integration of the learning management system in the form of integrated learning management the learning process, which is in line with monitoring the use of infrastructure in schools. Through this Smart Class concept, schools can still operate optimally without any applicable health policies and can provide excellent academic services.
Keywords: smart class system prototyping, sustainable infrastructure mobile application, SPACE smart building management system
Technology Empowerment in Learning: Student Perspective Study on Virtual Laboratory to Support Independent Learning in Independent Campus
Authors: Setiawan Wawan , . Sugianto , . Riandi , Prasetyo Yogi
Published: April 2024

Virtual laboratory is one of the solutions that can be used for practical or experimental activities in the context of independent learning on an independent campus, which is carried out outside the laboratory, especially during the Covid-19 pandemic. However, in practice, there are several obstacles so the use of virtual laboratories has not been massive. This study aims to analyze the student’s perspective on the virtual laboratory in forcing conditions during the Covid-19 pandemic. The research method uses a survey with a questionnaire technique to capture the perspectives of students of the Biology Education Study Program at one of the universities in West Java. The perspectives studied include innovation, urgency, usefulness, and motivation which are grouped into positive and negative perspectives. The results showed that most of the students had a positive perspective on the virtual laboratory by 81.64%, and a negative perspective of 18.36%. Among the four indicators, motivation is the smallest positive perspective although it is larger than the negative perspective. This research can give the conclusion that the virtual laboratory needs to be continuously developed along with the improvement of students’ technological skills or literacy.
Keywords: technology empowerment, student perspective study, virtual laboratory, independent learning
Introduction to Different Diagrams Commonly Used in Literature
Authors: Khan, MD, MSHs, LSSBB Ahmad , Fahim Soma , Nashir Saba , Ahmadi Shabnam , Muhammadzai Madina , Seddiq Seddiqi Ahmad
Published: April 2024

Diagrams help researchers and authors communicate and visualize complex concepts, data, and relationships effectively to a broader audience, including scientists, students, and the general public (Garcia-Retamero & Cokely, 2017). Visual representations can convey information more clearly and succinctly than paragraphs of text (Divecha et al., 2023; Duquia et al., 2014; Nguyen et al., 2021). Diagrams can take various forms, such as flowcharts, organizational charts, network diagrams, Venn diagrams, and others, and they are commonly used in various fields like business, engineering, science, education, and software development to illustrate processes, systems, relationships, and concepts. They help organize information, clarify relationships, identify patterns, and display data in an organized and visually attractive manner (Divecha et al., 2023; Duquia et al., 2014; Nguyen et al., 2021).
Solutions of Fuzzy Fractional Differential Equations
Authors: Harir Atimad ,   Laboratory of Mathematical Modeling and Economic Calculation Department of Economics, Faculty of Economics and Management, University Hassan 1er, Settat, Morocco, Melliani Said , Chadli Lalla Saadia ,   Laboratory of Applied Mathematics and Scientific Computing Sultan Moulay Slimane University P.O. Box 523, Beni Mellal, 23000, Morocco,   Laboratory of Applied Mathematics and Scientific Computing Sultan Moulay Slimane University P.O. Box 523, Beni Mellal, 23000, Morocco
Published: April 2024

The concept of generalized conformable fractional derivative is used to explore fuzzy fractional differential equations in this research. The extension of the class of differentiable fuzzy mappings underpins this concept. The summations and differences of two functions are produced using this derivative, and we prove the existence and uniqueness of a solution to a fuzzy fractional differential equation.
Analytical Solution of Cancer Cells Interaction with Virotherapy in the Framework of Fractional Derivative Operator
Authors: Sharma Manish ,   Department of Mathematics, Shri Lal Bahadur Shastri Degree College, Gonda, UP, India, Halder Manisha , Kumar Sanjeev , Pandey Sanjay K. ,   Department of Mathematics, St. John’s College, Agra, UP, India,   Department of Mathematics, Institute of Basic Sciences, Dr. B.R.Ambedkar University, Agra, UP, India,   Department of Mathematics, Shri Lal Bahadur Shastri Degree College, Gonda, UP, India
Published: April 2024

In this paper, we have introduced a mathematical model of virotherapy for medication of tumor cells by using fractional calculus. In the current model four differential conditions are presented which portray cooperation among non-infected tumor cells, infected tumor cells, virions and effector T cells. We will examine the presence and uniqueness of the introduced mathematical model. We will likewise concentrate on the local stability of equilibrium points. Then, we will discuss the numerical solutions to investigate the use of fractional order derivative and different variables. We will likewise plot a few charts to show the outcomes.
In silico Analysis and Molecular Docking of Cry3Aa Toxin with Coleopteran Specific Midgut Receptor of ADAM10/APN Receptors
Authors: Eniya Arumugam , Balasubramani Venkatasamy , Murugan Marimuthu , Raveendran Muthurajan , Pugalendhi Lakshmanan , Nirmala Ravikumar Caroline , Raghu Rajasekaran , Rajadurai Gothandaraman
Published: April 2024

Background: Bacillus thuringiensis (Bt) is widely recognized as a safe and effective bioinsecticide, with Cry toxins targeting pests of various insect orders. The present study focuses on the modeling and validation of the Cry3Aa protein (deduced amino acid sequence of cry3Aa gene cloned from native Bt isolate, T121) and its interaction with midgut receptor proteins (ADAM10 and APN). Methods: The three-dimensional structures of Cry3Aa protein and the midgut receptors ADAM10 and APN were predicted using the SWISS model server. Functional domain analysis of Cry3Aa revealed three distinct domains: N-terminal (Domain I), Central (Domain II) and C-terminal (Domain III), providing insights into their structural organization. The predicted models of Cry3Aa, ADAM10 and APN were validated using the Ramachandran plot which demonstrated structural integrity. Result: Primary structure analysis of Cry3Aa revealed a 652 amino acid protein with a theoretical isoelectric point of 5.59, a molecular weight of 74 kDa and stable characteristics. Protein-protein docking analysis using ClusPro 2.0 showed that Cry3Aa exhibited higher level of interaction with the ADAM10 receptor than with the APN receptor. The Cry3Aa-ADAM10 docked complex demonstrated 23 hydrogen bonds, reasoning for its stability and binding affinity. These findings revealed that the Cry3Aa protein has a strong affinity against coleopteran specific midgut receptors and hence Cry3Aa has a potential to be an effective coleopteran specific insecticidal protein.
Physiological and Biochemical Basis of Variation in Yield of Rice (Oryza sativa L.) under CA-based Crop Establishment Methods and Nutrient Management in R-W Cropping System
Authors: Bhangare R.V. , Singh U.P. , Jangde S. , Prakash P.
Published: April 2024

Background: Crop establishment methods and nutrient management practices treatments were continuously practiced in the same plots since 2011-12 as a part of long-term experiment. A field study was conducted during 2019-2020 and 2020-2021 i.e. during 9th and 10th year of study to investigate the effects of CE methods and nutrient management on growth, physiological, biochemical, yield attributes and yield of rice crop. Methods: Field experiments were carried out at the Agricultural Research Farm, Banaras Hindu University, Varanasi, laid out in split plot design replicated thrice with four crop establishment (CE) methods viz., CT (puddled transplanted) rice-CT wheat (CE1),CTDSR rice-CT wheat (CE2), CTDSR- ZT wheat (rice residue retention) (CE3), ZT rice-ZT wheat (residue retention in rice and wheat) (CE4) in main plots and three nutrient management (NM) practices viz., FP (164 kg N, 50 kg P2O5, 32 kg K2O and 4 kg Zn ha-1) (N1), RFD (150 kg N, 60 kg P2O5, 60 kg K2O and 5 kg Zn ha-1) (N2) and SSNM- RWCM recommendation (N3). The rice variety used was ‘Sarju-52’ in the present study. Result: The recorded data revealed that ZT rice–ZT wheat (CE4) recorded significantly higher plant height, tillers hill-1, leaf area, RWC, total chlorophyll content and protein content as compared to other CE methods. Among NM practices, SSNM-RWCM (N3) recorded significantly higher plant height, tillers hill-1, leaf area and protein content, whereas, RWC and total chlorophyll content did not differ significantly over farmer’s practice and recommended fertilizer dose. Improved growth and physio-chemical attributes in ZT rice-ZT wheat (CE4) and SSNM-RWCM (N3) resulted in significantly higher panicles hill-1, fertility percentage and number of filled grains panicle-1 over other CE methods and NM practices. Panicle length, spikelets panicle-1 and test weight showed non-significant differences. Grain yield, straw yield and biological yield were significantly higher in ZT rice-ZT wheat (CE4) among CE methods and SSNM-RWCM (N3) among NM practices. The harvest index showed non-significant differences for CE methods and NM practices both.
Optimization of Nata de Coco Industrial Liquid Waste Processing Using Membrane-Based Ultrafine Bubble Diffuser
Authors: Lukito Lukito Hasta Pratopo , Thoriq Ahmad , Ciptaningtyas Drupadi , Rifaldhy Muhammad
Published: April 2024

The nata de coco industry produces liquid waste which, if thrown directly into water bodies (rivers) without prior processing, has the potential to pollute the surrounding environment. Laboratory test results show that the parameters BOD 1145 mg/L, COD 1737 mg/L, and TSS 206 mg/l are far above the thresholds set by the government. The aim of this research is to determine the optimum conditions for fine bubble and micro bubble treatment of nata de coco liquid waste in reducing the characteristic values of nata de coco liquid waste. This research was carried out using experimental methods with test samples of 40 liters and 60 liters. Data collected through direct observation include DO, TDS, pH, temperature which are measured every 2 hours, while data collected through laboratory testing of BOD, COD and TSS which are tested every 12 hours and 24 hours. The data was then processed using the Taguchi method with the aim of optimizing the fine bubble treatment for changes in the characteristics of nata de coco liquid waste. The research results showed that the optimum conditions were found in the fine bubble treatment with an aeration period of 24 hours and a volume of 40 liters. The best percentage reduction in BOD was found to be 94% or 68 mg/L. COD reduction obtained the best percentage reduction of 93% and/or became 121 mg/L and TSS obtained the best percentage reduction of 69% or became 77 mg/L. These results are in accordance with the Regulation of the Minister of Environment of the Republic of Indonesia Number 5 of 2014 concerning Waste Water Quality Standards
Navigating the Digital Frontier: A Literature Review on Business Digitalization
Authors: Benga Btissam , Elhamma Azzouz
Published: April 2024

The rise of digital technology has compelled organizations to undergo significant changes or, at the very least, reassess their operational strategies. Many major corporations have poured significant financial resources into what is commonly referred to as "Digitalization." Digital transformation has become an imperative for businesses that want to survive and thrive in an ever-changing world. Faced with the rise of digital technology, organizations must imperatively adapt their processes, products and services to meet new customer expectations and remain competitive. Digitalization, the integration of digital technologies into various aspects of life and business, has revolutionized industries across the globe. Key components of this transformation include big data, artificial intelligence (AI), cloud computing, Internet of Things (IoT), and machine learning (ML) ,but even if Digitalization offers numerous benefits, including increased efficiency, innovation, and improved customer experiences, it also presents challenges such as security risks, the digital divide, technological dependency, and ethical considerations. Addressing these limitations is crucial to harnessing the full potential of digital technologies for positive societal impact. The objective of our article is to present a literature review on digitalization and provides an overview of the notable constraints and obstacles associated with digitalization and its advancement. It delves into the challenges related to the demand for digital resources, as well as the efficient and effective utilization thereof.
Cocaine-Induced Coronary Syndromes: Unraveling the Complex Pathophysiology and Clinical Implications
Authors: Gomez Coral Maria Isabel
Published: April 2024

Cocaine-induced coronary syndromes represent a significant public health concern, with complex pathophysiology and high morbidity and mortality rates. This article provides a comprehensive overview of the epidemiology, pathophysiology, clinical manifestations, diagnosis, management strategies, prognosis, and complications associated with cocaine-induced coronary syndromes. Epidemiological data suggest a notable increase in cocaine use globally, with significant implications for cardiovascular health. The pathophysiology of cocaine-induced coronary syndromes involves multifaceted mechanisms, including vascular dysfunction, myocardial ischemia, atherosclerosis, and thrombosis. Clinical manifestations range from asymptomatic electrocardiographic changes to life-threatening acute myocardial infarction, posing diagnostic challenges for healthcare professionals. Management strategies encompass a multidisciplinary approach, including pharmacological interventions, revascularization procedures, and behavioral interventions aimed at addressing both acute cardiovascular events and underlying substance abuse disorders. Despite advancements in medical therapy and preventive measures, the burden of cocaine-induced coronary syndromes remains substantial, highlighting the need for collaborative efforts to mitigate the impact of cocaine-related cardiovascular complications on public health and clinical practice.
RESPONSE SOLUTIONS OF 2-DIMENSIONAL ELLIPTIC DEGENERATE QUASI-PERIODIC SYSTEMS WITH SMALL PARAMETERS
Authors:   School of Mathematics, Southeast University, Nanjing, China, Ni Song
Published: April 2024

This paper concerns quasi-periodic perturbations with parameters of 2-dimensional degenerate systems. If the equilibrium point of the unperturbed system is elliptic-type degenerate. Assume that the perturbation is real analytic quasi-periodic with diophantine frequency. Without imposing any assumption on the perturbation, we can use a path of equilibrium points to tackle with the Melnikov non-resonance condition, then by the Leray-Schauder Continuation Theorem and the Kolmogorov-Arnold-Moser technique, it is proved that the equation has a small response solution for many sufﬁciently small parameters
The Non-Financial Information Contribution to Value Creation for Companies
Authors:   West University of Timisoara, Romania, FOMETESCU Adelina , HATEGAN Camelia Daniela ,   West University of Timisoara, Romania
Published: April 2024

Non-financial information plays an increasingly important role in creating value for companies and has become an essential factor in modern business strategies. While financial information provides insight into a company's past financial performance, non-financial information provides a more comprehensive and contextualized view of how the company interacts with its environment, employees, customers, society and other stakeholders. The objective of the paper is to identify the contribution of non-financial information to the value creation for companies. The studied population represents the companies listed on the Bucharest Stock Exchange that were evaluated from the point of view of the transparency of non-financial reporting for the financial year 2021. The indicators used are represented by: evaluation scores made by two specialized entities, the communication indicator - Vektor, the inclusion of companies in the BET index, return on equity, return on assets, profitability and the number of employees for the period of 2021. The results of the study showed that the analyzed companies were evaluated with acceptable scores by the evaluation entities and positive and negative correlations were found between the evaluation scores and the profitability indicators. In general, non-financial information provides critical insights to understand the social, environmental and economic impact of companies' activities and can significantly contribute to value creation, especially in the long term for companies and society as a whole.
New Design Options for Container Barges with Improved Navigability on the Danube
Authors: Duldner-Borca Bianca , Hoerandner Laura , Bieringer Bernhard , Khanbilverdi Reza , Putz-Egger Lisa-Maria
Published: April 2024

One of the measures required by the European Green Deal to decarbonise the freight transport sector is the promotion of inland waterway transport (IWT), in particular intermodal transport in Europe. To facilitate intermodal transport on the Danube, we developed six new barge designs for the transport of 45' pallet-wide high-cube containers using a four-step approach. Our approach consisted of detailed desk research, followed by design and further analysis of the identified barge types, taking into account, for example, sight lines or stability. The container carrying capacity reaches up to 90 containers in three layers, which is double the capacity of existing standard barges on the Danube. Nevertheless, three-layer transport is hardly feasible in several cases, due to restrictions regarding sight lines and stability. We conclude that each loading condition must be evaluated separately to determine the best barge design option for each case. The study is limited by its geographical scope and the type of container used to develop the new barge designs. This could be a possible direction for further research on this topic: using other container types and/or extending the geographical scope.
Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers and Therapeutic Targets for the Metabolic Bone Disease
Authors: Wang Jihan , Xue Mengju , Hu Ya , Li Jingwen , Li Zhenzhen , Wang Yangyang
Published: April 2024

Osteoporosis (OP), a prevalent skeletal disorder characterized by compromised bone strength and increased susceptibility to fractures, poses a significant public health concern. This review aims to provide a comprehensive analysis of the current state of research in the field, focusing on the application of proteomic techniques to elucidate diagnostic markers and therapeutic targets for OP. The integration of cutting-edge proteomic technologies has enabled the identification and quantification of proteins associated with bone metabolism, leading to a deeper understanding of the molecular mechanisms underlying OP. In this review, we systematically examine recent advancements in proteomic studies related to OP, emphasizing the identification of potential biomarkers for OP diagnosis and the discovery of novel therapeutic targets. Additionally, we discuss the challenges and future directions in the field, highlighting the potential impact of proteomic research in transforming the landscape of OP diagnosis and treatment.
Autoimmune Encephalitis Following Check Point Inhibitor Therapy in a Patient with Metastatic Melanoma in Complete Remission
Authors: Civardi Giuseppe , Medioli Alessia , Braghieri Carlotta , Ambroggi Massimo , Immovilli Paolo , Orsucci Simone , Contini Paolo , Aronica Giuseppe , Cavanna Luigi
Published: April 2024

A 68-year-old man with malignant metastatic melanoma in complete remission after Pembrolizumab treatment, developed 10 months after Pembrolizumab cessation due a grade 3 diarrhea, confusion, altered mental status, progressive memory loss, gait disturbance. He was admitted to the neurologic department and comprehensive neurological workup, brain magnetic resonance imaging, cerebral fluid analysis, EEG, blood test allowed the diagnosis of autoimmune encephalitis. The patient was treated with plasmapheresis, high dose of intravenous steroids and intravenous immunoglobulins. The patient improved and he is now well with a performance status 1. This case is interesting since the AE developed approximately 10 months after the cessation of immunotherapy, the underlying cancer was in complete remission and the AE showed a good response to the treatment done.
Prediction of Suitable Habitat of Alien Invasive Plant Ambrosia trifida in Northeast China under Various Climatic Scenarios
Authors: Chen Shengjie , Bai Xuejiao , Ye Ji , Chen Weiwei , Xu Guanghao
Published: April 2024

Ambrosia trifida is a kind of malignant invasive plant, which has very high reproductive and en-vironmental adaptability. Through strong resource acquisition ability and allelopathy, it could inhibit the growth and reproduction of surrounding plants, destroy the stability of an invasive ecosystem. It is very important to predict the change of suitable distribution area of Ambrosia trifida with climate change before implementing scientific control measures. Based on 106 Ambrosia trifida distribution data and 14 environmental data, the optimal parameter combination (RM = 0.1, FC = LQ) was obtained by using the MaxEnt model optimized by Kuenm package, the potential suit-able areas of Ambrosia trifida in Northeast China under three different climate scenarios (RCP2.6, RCP4.5, RCP8.5) with different emission intensities in the future (2050,2070) were predicted. The changes of Ambrosia trifida suitable area in Northeast China under three climate scenarios were compared, and the relationship between the change of suitable area and emission intensity was analyzed. In general, the suitable area of Ambrosia trifida in Northeast China will expand gradually in the future, and the area of its highly suitable area will also increase with the increasing emission intensity, which is unfavorable to the control of Ambrosia trifida.
Peritoneal Dialysis Induced Encapsulating Peritonitis – Diagnostic and Therapeutic Challenges in Women with Benign Gynecological Pathology
Authors: Iorga Cristian , Iorga Cristina Raluca , Andreiana Iuliana , Stancu Simona Hildegard , Constantin Traian , Strambu Victor
Published: April 2024

Background: Peritoneal sclerosis (PS) and its most severe form, encapsulating PS (EPS), are rare entities that can occur in various procedures (liver transplantation, intraperitoneal chemotherapy), secondary to medications ( beta-blockers); however, PS or EPS typically occur in patients undergoing peritoneal dialysis as a form of renal function substitution. Medical or surgical treatments can be applied, but morbidity and mortality have high rates . This condition typically presents clinically as an intestinal obstruction caused by the inclusion of the intestinal loops in the peritoneal fibrous membrane. Methods: Herein we present data from a single tertiary surgery center that has dedicated teams for patients receiving dialysis. In 12 years we analyzed a group of 63 patients admitted for catheter replacement/removal or for acute surgical pathology. In 5 cases (7,9%) we diagnosed EPS . Two patients with EPS presented with atypical abdominal pathologies requiring emergency surgery: one case of hemoperitoneum caused by a ruptured ovarian cyst and one case of uterine fibroids and metrorrhagia. Results: The definitive diagnoses were established intraoperatively and by analyzing the morpho-pathological changes of the peritoneum. The possible intraoperative challenges included laborious dissection, difficulties in restoring the correct anatomical landmarks, increased duration of the surgical intervention and a high rate of incidents and accidents Conclusions: The aim of the present study was to emphasize the possibility of other surgical pathologies overlapping with EPS, increasing the complexity of the surgical intervention. Also, we sought to determine whether there is a correlation between the morpho-pathological results of these patients who underwent emergency surgery and the common EPS morpho-pathological changes.
Dietary aspects in the treatment of inflammatory bowel disease
Authors:   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Khavkin A.I. ,   Belgorod State National Research University, Belgorod, Russian Federation, Nalyotov A.V. ,   M.Gorky Donetsk State Medical University, Ministry of Health of the Russian Federation, Donetsk, Shumilov P.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Sitkin S.I. ,   Almazov National Medical Research Centre, Saint Petersburg, Russian Federation,   I.I.Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation, Marchenko N.A. ,   M.Gorky Donetsk State Medical University, Ministry of Health of the Russian Federation, Donetsk
Published: April 2024

Inflammatory bowel disease (IBD) is a group of chronic diseases of the gastrointestinal tract. In recent years, the prevalence of IBD has increased worldwide. The potential effect of diet and certain food components that are directly or indirectly involved in the pathogenesis of intestinal lesions in IBD is not fully understood. The assessment of the effect of diet on the course of pathology is very complex since, regardless of the nutritional model adopted, each of them is based on the consumption of many different food groups that influence each other. This article describes the dietary patterns that are most discussed in scientific studies as a factor potentially influencing the activity of IBD. Key words: inflammatory bowel disease, nutrition, gut microbiota, lactose-free diet, low-FODMAP diet, gluten-free diet, total enteral nutrition, CDED diet
Sarcopenia and Crohn's disease in children
Authors:   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Khavkin A.I. ,   Belgorod State National Research University, Belgorod, Russian Federation, Alimov M.M. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Alimov M.M. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Yablokova E.A. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Erokhina M.I. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation
Published: April 2024

Sarcopenia is a significant health problem in developed countries as it increases the risk of fractures, impairs the ability to move independently and perform daily activities, relates to cardiovascular and respiratory diseases, cognitive impairment, reduces the quality of life, and imposes a financial burden on health care systems. Sarcopenia is characterized by progressive and generalized loss of muscle mass, deterioration in the quality of muscle architecture, and a decrease in muscle functionality, which predicts an unfavorable outcome. Recently, reports have appeared in the literature about the development of sarcopenia in patients with Crohn's disease. However, the mechanism of muscle loss in this inflammatory bowel disease is not fully understood. In this review, we present the possible pathophysiological mechanisms of Crohn's disease that contribute to the development of functional muscle failure and low performance. The literature review also presents potential treatments that may alleviate the development of sarcopenia in Crohn's disease. Key words: sarcopenia, Crohn's disease, inflammatory bowel disease, muscle mass, gut-muscle axis