bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient Influencers: The Next Frontier in Direct-to-Consumer Pharmaceutical Marketing (Preprint)
Authors: Willis Erin , Delbaere Marjorie
Published: April 2021

UNSTRUCTURED

Social media influencers are becoming an increasingly popular strategic communication tactic used across industry verticals, including entertainment, fashion, and beauty, to engage directly with consumers. Pharmaceutical companies have also recently entered the social media marketing arena and—within the bounds of governmental regulations—have found ways to build relationships directly with patients using covert persuasion tactics like partnering with social media influencers. Due to consumers’ negative perceptions of pharmaceutical companies, it makes sense that new marketing tactics are being used to establish and improve relationships with consumers. Previous research well documents the ethical dilemmas of direct-to-consumer advertising, and there is recent burgeoning literature on online covert marketing tactics. The academic and medical literature, however, is behind in regard to social media influencers used in health and medicine. This paper highlights and defines terms used in industry practice, and also calls for more investigation and sets forward a research agenda. As consumers spend more time online and patients continue to consult social media for health information, it is important that this new marketing trend does not go unnoticed.
Algorithm for Individual Prediction of COVID-19–Related Hospitalization Based on Symptoms: Development and Implementation Study (Preprint)
Authors: Murtas Rossella , Morici Nuccia , Cogliati Chiara , Puoti Massimo , Omazzi Barbara , Bergamaschi Walter , Voza Antonio , Rovere Querini Patrizia , Stefanini Giulio , Manfredi Maria Grazia , Zocchi Maria Teresa , Mangiagalli Andrea , Brambilla Carla Vittoria , Bosio Marco , Corradin Matteo , Cortellaro Francesca , Trivelli Marco , Savonitto Stefano , Russo Antonio Giampiero
Published: April 2021

BACKGROUND

The COVID-19 pandemic has placed a huge strain on the health care system globally. The metropolitan area of Milan, Italy, was one of the regions most impacted by the COVID-19 pandemic worldwide. Risk prediction models developed by combining administrative databases and basic clinical data are needed to stratify individual patient risk for public health purposes.

OBJECTIVE

This study aims to develop a stratification tool aimed at improving COVID-19 patient management and health care organization.

METHODS

A predictive algorithm was developed and applied to 36,834 patients with COVID-19 in Italy between March 8 and the October 9, 2020, in order to foresee their risk of hospitalization. Exposures considered were age, sex, comorbidities, and symptoms associated with COVID-19 (eg, vomiting, cough, fever, diarrhea, myalgia, asthenia, headache, anosmia, ageusia, and dyspnea). The outcome was hospitalizations and emergency department admissions for COVID-19. Discrimination and calibration of the model were also assessed.

RESULTS

The predictive model showed a good fit for predicting COVID-19 hospitalization (C-index 0.79) and a good overall prediction accuracy (Brier score 0.14). The model was well calibrated (intercept –0.0028, slope 0.9970). Based on these results, 118,804 patients diagnosed with COVID-19 from October 25 to December 11, 2020, were stratified into low, medium, and high risk for COVID-19 severity. Among the overall study population, 67,030 (56.42%) were classified as low-risk patients; 43,886 (36.94%), as medium-risk patients; and 7888 (6.64%), as high-risk patients. In all, 89.37% (106,179/118,804) of the overall study population was being assisted at home, 9% (10,695/118,804) was hospitalized, and 1.62% (1930/118,804) died. Among those assisted at home, most people (63,983/106,179, 60.26%) were classified as low risk, whereas only 3.63% (3858/106,179) were classified at high risk. According to ordinal logistic regression, the odds ratio (OR) of being hospitalized or dead was 5.0 (95% CI 4.6-5.4) among high-risk patients and 2.7 (95% CI 2.6-2.9) among medium-risk patients, as compared to low-risk patients.

CONCLUSIONS

A simple monitoring system, based on primary care data sets linked to COVID-19 testing results, hospital admissions data, and death records may assist in the proper planning and allocation of patients and resources during the ongoing COVID-19 pandemic.
Management Effectiveness of Rinjani-Lombok Geopark on Geotourism Track
Authors: Kartika Ayu Puspa , Wibisono Bambang Hari
Published: April 2021

Managing the Geopark involves the integration between several aspects; conservation, education, and the sustainable community economic development. Multistakeholder is responsible for managing the Geopark. To make it effective, the stakeholders should work equally balanced. This study is aimed to evaluate the management effectiveness of Geopark in Geotourism track with specified theme. The method that was used in this study is descriptive quantitative approach, with the help of rating scale to analyze partial scoring and managing, as well as in each aspect and as a whole. This research was done at Rinjani-Lombok Geopark which focused on Geotourism track 2: the Ancient Volcanic Mountains Trail in Sembalun Valley and Geotourism Track 3: The Youngest Volcanic Mountain, Rinjani. The respondents were chosen by non-probability-sampling method, which is purposive sampling. It consists of Geopark management, government, locals, and tourists. As a result, it is shown that the management effectiveness is considered average, and also there are some imbalances found among the aspects mentioned. Educational aspect has the lowest efficiency, while the rests of the aspects are on average level. There are several indicators that influenced in educational aspect, and one of them is caused by the worst management.
Populisms: Inherently Illiberal or Plausibly Democratic?
Authors: Preciado Coronado Jaime A.
Published: April 2021

The central question of this paper is whether a constructive relationship between populism and democratisation may exist, or whether all types of populism inevitably lead to illiberal regimes. Anglo-Saxon and Eurocentric traditions tend to identify populism with fascism, as in the case of authoritarian right-wing regimes, or with left-wing politics as in the case of socialist or communist systems that produce totalitarian regimes. Critical theorists consider populism to be a reaction to a perceived gap separating democratic institutions from the popular sovereignty from which political regimes derive their legitimacy. This paper examines populisms from three main perspectives: (1) negative views of populism from a liberal democracy perspective; (2) positive views from theorists who see populism as a legitimate expression of popular sovereignty; and (3) some ways in which populism may be viewed based on Leonardo Morlino’s definition of a hybrid regime and the experiences of several Latin American countries.
A pilot study on exertional tasks with physiological measures designed for the assessment of military concussion
Authors: Prim Julianna H , Davila Maria I , McCulloch Karen L
Published: April 2021

Background: Guidelines for clinicians treating military concussion recommend exertional testing before return-to-duty, yet there is currently no standardized task or inclusion of an objective physiological measure like heart rate variability (HRV). Methodology & results: We pilot-tested two clinically feasible exertional tasks that include HRV measures and examined reliability of a commercially available heart rate monitor. Testing healthy participants confirmed that the 6-min step test and 2-min pushup test evoked the targeted physiological response, and the Polar H10 was reliable to the gold-standard electrocardiogram. Conclusion: Both tasks are brief assessments that can be implemented into primary care setting including the Polar H10 as an affordable way to access HRV. Additional research utilizing these tasks to evaluate concussion recovery can validate standardized exertional tasks for clinical use.
Influencia del entorno financiero, el entorno macroeconómico, la estructura organizacional y la transparencia en la quiebra empresarial
Authors: Támara Ayús Armando Lenin , Villegas Arias Gladis Cecilia
Published: April 2021

El papel que tienen las empresas en la economía de cualquier país no solo se debe mirar desde una óptica económica y financiera, sino también desde una mirada organizacional y de transparencia. La siguiente investigación plantea y desarrolla un Modelo de Ecuaciones Estructurales (MES) de tipo formativo fundamentado en Mínimos Cuadrados Parciales (PLS) con el objeto de evaluar el grado de influencia que ejercen los constructos Entorno Financiero, Entorno Macroeconómico, Estructura Organizacional y la Transparencia en la Quiebra Empresarial. Se trabaja con una muestra de 2.000 empresas que se estructuraron con base en los reportes de insolvencia que emite la Superintendencia de Sociedades de Colombia. Los resultados indican que cada uno de los constructos propuestos influye sobre el evento de la quiebra empresarial, siendo el constructo con mayor influencia el Entorno Financiero, mientras que, la Estructura Organizacional el de menor influencia.
Laboratorio portátil y aprendizaje de la Química
Authors: Vizcarra Sánchez Yanira Aracely , Vizcarra Gavilán Arturo Manuel
Published: April 2021

Para enseñar las ciencias químicas es necesario la teoría y práctica de los temas tratados. Durante el desarrollo de las prácticas profesionales se ha observado algunos colegios en la ciudad de Huancayo, no cuentan con laboratorios y materiales para desarrollar sus prácticas, es por ello, mediante este estudio se propone un Laboratorio Portátil [1](LP) como alternativa al problema, evaluando la influencia del LP en el aprendizaje de la química en estudiantes de tercero de secundaria. Se trabajó con dos aulas, una experimental (tercero C) y un control (tercero B) de una institución educativa de Huancayo. Además, se modificaron las planeaciones vigentes del Ministerio de Educación (MINEDU), introduciendo el LP y se aplicaron las evaluaciones pre y post de la experimentación. Los resultados evidenciaron que, el LP en los estudiantes mejora del rendimiento académico en el aula experimental. (tc=-5,805, p value < 0.001).

[1] Es una maleta cuyo contenido son materiales son los básicos que pueden ser utilizados con los estudiantes de secundaria como vaso precipitado, mechero de alcohol, pipeta, tubos de ensayo, etc, y los reactivos que contiene esta maleta están en forma disuelta, es decir que no son muy concentradas teniendo en cuenta las medidas de seguridad que se debe de tener con adolescentes
Factor affecting user satisfaction in agricultural e-commerce applications: Facing the new normal
Authors: Nusifera Alfa Nursyamiza , Najib Mukhamad , Kirbrandoko Kirbrandoko
Published: April 2021

Agricultural E-Commerce with a retail business model has a big challenge to become an alternative sales distribution of agricultural products. Consumer satisfaction and loyalty can be a strategy for companies to maintain and increase sales. The purpose of this study was to analyze the users of agricultural e-commerce application characteristics and variables that affect customer satisfaction and loyalty. It was conducted by a survey in the Greater Jakarta area, Indonesia. Research data were collected using a questionnaire with a convenience sampling method to 170 respondents. The majorities of respondents were women with an age range of 20-30 years. Structural Equation Modeling (SEM) results show that there is a significant influence between information quality, design, response, security, delivery on satisfaction, and satisfaction with loyalty. On the other hand, there is no significant difference between ability, payment, user service, and satisfaction. Companies can create loyalty programs to increase product purchase retention in agricultural e-commerce.
Model of Flexible Periodic Vehicle Routing Problem-Service Choice Considering Inventory Status
Authors: Rizal Muhammad Alde , Saidatuningtyas Ifa
Published: April 2021

Vehicle routing problems and inventory problems need to be integrated in order to improve performance. This research discusses the determination of vehicle routes for product delivery with periodic delivery times that are released at any time depending on the inventory status. A mixed-integer linear programming model in determining periodic flexible visiting vehicles' route considering inventory is proposed to solve this problem. This model also accommodates time window constraints, retailer warehouse capacity. The search for solutions was carried out using the branch-and-bound method with the help of Lingo 18.0. The mathematical model testing result saves shipping costs and inventory costs. In addition, the developing mathematical model offers the flexibility of visiting depending on the inventory status of the consumer. The sensitivity analysis of the model results in the vehicle capacity influence the total cost and routes formed.
Measurement of Customer Perceptions of Logistics Service Quality
Authors: Ogunnowo Babatunde Enitan , Sule Salami Suberu
Published: April 2021

Currently, logistics service providers experience a high increase in activity. It makes logistics service providers compete with each other in service quality. To be able to compete, logistics service providers need to measure customer perceptions on logistics service satisfaction. The results of measuring customer perceptions can be used to improve the quality of logistics services. This study attempted to measure customer perceptions of third-party logistics (3PL) service users by considering competitor performance factors. This study integrated the Customer Satisfaction Index (CSI) method and the Competitive Zone of Tolerance based Importance Performance Analysis (CZIPA) method to measure customer perceptions and determine the priority attributes for improvement account competitors' performance factors. Based on the research, the CSI method was proven to measure customer perceptions of 3PL service users. CZIPA can determine the attributes that were prioritized for improvement based on the performance of competitors.
The Effect of Logistical-Crossfunctional Drivers on the Competitive Strategy of the Supply Chain of SMEs: A Case Study
Authors: Sumarsono Sumarsono , Muflihah Nur
Published: April 2021

Small and Medium Enterprises (SMEs) dominate the business world in Indonesia with a high Gross Domestic Product contribution. However, SMEs are unable to compete with large industries due to uncompetitive supply chains. The logistical-crossfunctional aspect of drivers is an aspect driving a competitive supply chain. This study aims to examine the effect of logistical-crossfunctional drivers on the competitive strategy of the supply chain for SMEs in Indonesia. The case study was conducted in SMEs scattered in East Java, Indonesia. The data analysis method used PLS-SEM. The results showed that the logistical-crossfunctional aspects of SME drivers have a significant effect on the supply chain competitive strategy. The implications of the research results are used to develop supply chain strategies for SMEs with a priority scale of logistical-crossfunctional drivers such as 1) facilities; 2) sourcing; 3) information; 4) transportation; 5) inventory; and 6) pricing.
Tradisi Ruwatan Jawa pada Masyarakat Desa Pulungdowo Malang
Authors: Susanti Jijah Tri , Lestari Dinna Eka Graha
Published: April 2021

Jawa yang merupakan salah satu suku terbesar di Indonesia juga memiliki keanekaragaman budaya. Masyarakat Jawa kental dengan kepercayaan mistis atau sering disebut juga kepercayaan dalam dunia Spiritual.  Masyarakat Jawa memiliki beragam teori yang menjadi dasar dilakukannya sebuah ritual. Upacara atau ritual yang dilakukan untuk menghindarkan diri dari dampak yang ditimbulkan akibat kesalahan manusia, dalam masyarakat Jawa disebut ruwatan. Tujuan penelitian ini adalah untuk mengetahui sejarah asal mula tradisi ruwatan adat Jawa bagi anak perempuan tunggal, mengetahui makna yang terkandung dalam tradisi ruwatan adat Jawa bagi anak perempuan tunggal, dan proses tradisi ruwatan adat Jawa bagi anak perempuan tunggal sebelum melakukan pernikahan. Metode penelitian ini adalah deskriptif kualitatif. Penelitian dilakukan di Desa Pulungdowo Kabupaten Malang. Sumber data penelitian ini adalah informan dan fenomena tradisi ruwatan. Teknik pengumpulan data dilakukan dengan observasi, wawancara dan studi dokumen. Teknik analisa data dilakukan dengan reduksi, interpetasi, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa asal muasal adanya Ruwatan adalah dari cerita pewayangan ada seorang tokoh yang bernama Batara Guru dia beristrikan dua orang istri yaitu Pademi dan Selir. Ruwatan dilakukan dengan menggelar pertunjukan wayang lakon Murwakala. Dalang akan menyajikan sesaji khusus untuk memuja batarakala. Pada acara pamungkas dalang membaca mantra dengan iringan gamelan dan gending sebagai tolak bala (mengusir Batarakala). Makna dari ruwatan adalah meminta dengan sepenuh hati agar pelakunya lepas dari petaka dan memperoleh rahayu keselamatan. Hal tersebut memperlihatkan masih kuatnya kepercayaan masyarakat terhadap mitos dan tradisi utamanya bagi ruwatan anak perempuan tunggal sebelum melangsungkan pernikahan.
Regularity Of Cubic Graph With Application
Authors: Krishna Kishore Kumar , Rashmanlou Hossein , Talebi Ali Asghar , Mofidnakhaei Farshid
Published: April 2021

A cubic graph is a generalized structure of a fuzzy graph that gives moreprecision, flexibility and compatibility to a system when compared with systems thatare designed using fuzzy graphs. In this paper, some properties of an edge regularcubic graph are given. Particularly, strongly regular, edge regular and bi-regularcubic graphs are defined and the necessary and sucient condition for a cubic graphto be strongly regular is studied. Likewise, we have introduced a partially edgeregular cubic graph and fully edge regular cubic graph with suitable illustrations.Finally, we gave an application of cubic digraph in travel time.
Determination of the Some Results for Coupled Fixed Point Theory in C*-Algebra Valued Metric Spaces
Authors: Omran Saleh , ÖZER Özen
Published: April 2021

In the present paper, we introduce the coupled xed point theorem in C*-algebra valued metric spaces. We get a C*-algebra valued metric space which get values in noncomutative operators. We demonstrate existance and uniqeness of coupled fixed point in a such space. Besides, we support our results by giving numerical examples.
Numerical Solutions for Convective Boundary Layer Flow of Micropolar Jeffrey Fluid with Prescribe Wall Temperature
Authors: Rawi Noraihan Afiqah , Mohd Zin Nor Athirah , Khalid Asma , Mohd Kasim Abdul Rahman , Mat Isa Zaiton , Shafie Sharidan
Published: April 2021

The steady two dimensional convective boundary layer flow of micropolar Jeffrey fluid past a permeable stretching sheet is studied in this paper. The governing boundary layer equation in the form of partial differential equations are transformed into nonlinear coupled ordinary differential equations and solved numerically using an implicit finite-difference scheme known as Keller-box method. The effects of Prandtl number, Deborah number, and material parameter with the boundary condition for microrotation, n = 0 (strong concentration of microelements) on the velocity, microrotation, temperature profiles as well as the skin friction and heat transfer coefficients are presented and discussed. An excellent agreement is observed between the present and earlier published results for some special cases. The results revealed that, the effect of Deborah number and stretching parameter are increased the heat transfer coefficient while the opposite trend is observed for the effects of material and velocity slip parameters. It was also observed that, the values of skin friction increased with the increment on the values of all studied parameters.
Projective Curvature Tensor with Respect to Zamkovoy Connection in Lorentzian Para-Sasakian Manifolds
Authors: Mandal Abhijit , Das Ashoke
Published: April 2021

The purpose of the present paper is to study some properties of the Projective curvature tensor with respect to Zamkovoy connection in Lorentzian Para Sasakian manifold(or,LP-Sasakian manifold)'And we have studied some results in Lorentzian Para-Sasakian manifold with the help of Zamkovoy connection and Projective curvature tensor.Also we discussed the LP-Sasakian manifold satisfying P*(ξ,U)∘W₀*=0,P*(ξ,U)∘W₂*=0 , where W₀*,W₂* and P* are W₀,W₂ and Projective curvature tensors with respect to Zamkovoy connection.
Central Graph of Quadrilateral Snakes with Chromatic Number
Authors: Mansuri Akhlak , Mehta Rohit , Chandel R S
Published: April 2021

This article shows the study about the harmonious coloring and to investigate the harmonious chromatic number of the central graph of quadrilateral snake, double quadrilateral snake, triple quadrilateral snake, k-quadrilateral snake, alternate quadrilateral snake, double alternate quadrilateral snake, triple alternate quadrilateral snake and k-alternate quadrilateral snake, denoted by C(Qn), C(DQn), C(TQn), C(kQn), C(AQn), C(D(AQn)), C(T(AQn)), C(k(AQn)) respectively.
Strong Convergence of A Hybrid Method for Infinite Family of Nonexpansive Mapping and Variational Inequality
Authors: Rathee Savita , Swami Monika
Published: April 2021

The motivation behind this paper is to use hybrid method for searching a typical component of the set of fixed point of an infinite family of non expansive mapping and the set of monotone, Lipschtiz continuous variational inequality problem. The contemplated method is combination of two method one is extragradient method and the other one is DQ method. Also, we demonstrate the strong convergence of the designed iterative technique, under some warm conditions.
ANALISIS PENGARUH RASIO AKTIVITAS, RASIO PROFITABILITAS, RASIO LIKUIDITAS, DAN LEVERAGE TERHADAP RETURN SAHAM PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI JAKARTA ISLAMIC INDEX PERIODE 2013-2017
Authors: Abrar Sayid , Ahmadsyah Israk , Iskandar Evy
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh rasio aktivitas (TATO), rasio profitabilitas (ROE), rasio likuiditas (CR), dan leverage (DER) terhadap Return Saham Perusahaan Manufaktur yang terdaftar di JII. Teknik pengumpulan data pada penelitian ini menggunakan dokumentasi yaitu laporan keuangan triwulan perusahaan manufaktur periode 2013-2017. Uji yang digunakan dalam penelitian ini adalah analisis regresi data panel dengan bantuan software Eviews versi 9. Hasil penelitian menunjukkan rasio aktivitas (TATO) berpengaruh negatif dan signifikan terhadap return saham. Rasio Profitabilitas (ROE) berpengaruh positif signifikan terhadap return saham. Rasio likuiditas (CR) dan leverage (DER) tidak berpengaruh terhadap return saham. Secara simultan rasio aktivitas (TATO), rasio profitabilitas (ROE), rasio likuiditas (CR), dan leverage (DER) tidak berpengaruh terhadap Return Saham.
ANALISIS HAMBATAN PERTUMBUHAN PERBANKAN SYARIAH DI INDONESIA (Kajian Terhadap Perbankan Syariah Di Aceh)
Authors: Nadia Sarah , Ibrahim Azharsyah , Jalilah Jalilah
Published: April 2021

Pertumbuhan perbankan syariah relatif lebih kecil dibandingkan perbankan nasional yang berarti masih ada hambatan-hambatan atau kendala-kendala yang harus ditaklukkan perbankan syariah. Begitupun halnya di Aceh yang dijuluki daerah serambi Makkah, seharunya menjadi potensi besar dalam pengembangan perbankan syariah. Namun faktanya hingga saat ini, perkembangan perbankan syariah di Aceh juga masih tertinggal disbanding perbankan konvensional. Tujuan penelitian adalah untuk mengetahui apa saja hambatan yang dialami oleh perbankan syariah di Aceh dalam pertumbuhannya. Penelitian ini merupakan penelitian deskriptif kualitatif, untuk mendapatkan hasil penelitian digunakan teknik pengumpulan data berupa wawancara dan dokumentasi. Hasil dari penelitian ini menunjukkan bahwa, hambatan pertumbuhan perbankan syariah di Aceh antara lain berupa kurangnya SDM yang memahami perbankan syariah secara mendalam, kurangnya sosialisasi yang didapatkan masyarakat, sedikitnya literasi yang diterima masyarakat terkait perbankan syariah, kurangnya minat dan kepercayaan masyarakat terhadap perbankan syariah, serta keterlambatan adanya regulasi yang khusus mengatur tentang perbankan syariah. Dan hal tersebut tidak hanya berlaku bagi keterlambatan atau hambatan pertumbuhan perbankan syariah di Aceh saja, akan tetapi hambatan tersebut juga dialami oleh perbankan syariah secara nasional.
Comparative Characteristics of the Constitutional and Legal Status of the Senior Official of the Constituent Entities of the Russian Federation – the Cities of Moscow and St. Petersburg
Authors:   Autonomous Non-Profit Organization “Financial Commissioner Operations Support Service” in St. Petersburg, Volochkovskaya M.A.
Published: April 2021

The article provides a theoretical and comparative analysis of the constitutional and legal status of the senior official of the constituent entities of the Russian Federation — the cities of Moscow and St. Petersburg. The author highlighted the main elements of the constitutional and legal status of a senior official of a constituent entity of the Russian Federation, the classification of which became the basis for the proposed methodology for a comparative analysis of the statuses of senior officials of cities of federal significance (Moscow and St. Petersburg) in the context of regional norms. A comparative analysis based on the proposed methodology led to conclusions about the similarities and differences in the constitutional and legal statuses of the Moscow Mayor and the Governor of St. Petersburg.
Opportunities of the Intervention of the Central (Regional) Government in the Decisions and Operations of the Local Governments in Hungary
Authors:   Eötvös Loránd University, Hoffman Istva´n ,   Institute for Legal Studies,   Marie Curie-Skłodowska University Hungary
Published: April 2021

The regulation on the relationship of the central and local governments in Hungary has transformed significantly in the last decade. However, the government have strong tools for the control of the local activities, these tools are just rarely applied by the supervising authorities. The main transformation of that relationship could be observed in the field of the public service provisions. The former municipally based public service system was transformed into a centrally organised and provided model, thus the role of the local governments in Hungary has decreased. The centralisation process have been strengthened by the reforms during the COVID-19 pandemic.
Awarding the Sign “Resident of Beleaguered Sevastopol” as a New Basis for Assigning Persons to the Category of Veterans of the Great Patriotic War
Authors:   Executive Committee of the Kaliningrad Regional Branch of the Russian Lawyers Association, Elaev A.A.
Published: April 2021

In this article, the author considers persons awarded the sign “Resident of Beleaguered Sevastopol” as a new basis for classifying persons as veterans of the Great Patriotic War, introduced into the legislation of the Russian Federation in 2020, drawing an analogy with the status of persons awarded with the sign “Resident of Blockaded Leningrad » In order to improve the specified subcategory of veterans of the Great Patriotic War. According to the author, the legal relationship regarding the assignment of the federal title of veteran of the Great Patriotic War for persons who lived in beleaguered Sevastopol currently includes, in addition to the material and legal component (the fact of a person’s residence in Sevastopol during the specified period), also procedural component in the sphere of awards of the subject of the Russian Federation, which is at the discretion of the legislator of the subject of the Russian Federation. The author proposes to abandon the criterion for awarding a sign in favor of establishing in the federal law specific criteria for the residence of persons in a certain territory during the Great Patriotic War, to adopt a Resolution of the Government of the Russian Federation on the procedure for determining persons falling under the criteria of residence in these cities, so that this determination can be carried out on the entire territory of the Russian Federation, and also establish a single criterion for referring to veterans of the Great Patriotic War for residents of beleaguered Sevastopol and blockaded Leningrad, associated with the fact of living in these cities during the beleaguer (blockade).
Foucault’s Keystone: Confessions of the Flesh
Authors: Harcourt Bernard E.
Published: April 2021

The fourth and final volume of The History of Sexuality offers the keystone to Michel Foucault’s critique of Western neoliberal societies. Confessions of the Flesh provides the heretofore missing link that ties Foucault’s late writings on subjectivity to his earlier critique of power. Foucault identifies in Augustine’s treatment of marital sexual relations the moment of birth of the modern legal actor and of the legalization of social relations. With the appearance of the modern legal subject, Foucault’s critique of modern Western societies is complete: it is now possible to see how the later emergence of an all-knowing homo œconomicus strips the State of knowledge and thus deals a fatal blow to its legitimacy. The appearance of both the modern legal actor and homo œconomicus makes it possible to fold the entire four-volume History of Sexuality back into Foucault’s earlier critique of punitive and biopolitical power. And it now challenges us to interrogate how we, contemporary subjects, are shaped in such a way as to implicate ourselves—both willingly and unwittingly—in the social order within which we find ourselves and that, through the interaction of knowledge-power-subjectivity, we reproduce.
Dupuytren’s contracture treated with botulinum toxin A injection
Authors:   University of California, Irvine, CA, USA, Davis Shane Michael , Chang Eric Yao ,   Restore Orthopedics & Spine Center, Orange, CA, USA
Published: April 2021

Dupuytren’s contracture is a condition in which fibromatosis of the palmar and digital fascia can lead to painful contractures of the hand. Common conservative treatments are of limited efficacy, while invasive options have risk of adverse effects. A 57-year-old female presented with chronic, bilateral hand pain secondary to Dupuytren’s contractures. Traditional conservative treatments did not provide relief. She received a series of three botulinum toxin A injections into the palmar fascia of both hands, resulting in four months of improved hand function and pain relief. This case presents a novel treatment for Dupuytren’s contracture using botulinum toxin injection. Botulinum toxin has inhibitory effects on the neuromuscular junction and pain signaling pathways to relax muscles and reduce pain. We believe its action on this patient’s intrinsic hand muscles resulted in her improved hand function. Botulinum toxin injection can be considered as a treatment option for Dupuytren’s contracture.
Patients’ attitudes toward seasonal influenza immunization
Authors: Kolundzic Mirjana , Bojat Veselin , Krasnik Rastislava , Zvekic-Svorcan Jelena , Lacokova-Krasnikova Jarmila , Dimitrov Dejan
Published: April 2021

Introduction. Immunization is an important measure in the prevention of
diseases that can seriously endanger health of the population. The aim of
the study was to determine the attitudes of the adult population toward
seasonal influenza immunization. Material and Methods. This cross-sectional
prospective study including 160 adult subjects of both sexes was conducted
from November 15, 2019 to December 15, 2019 at the General Medicine
Department of the ?Liman? Health Center, Novi Sad, Serbia. The respondents
filled out a questionnaire, specifically designed for this purpose. The
collected data were used to analyze the influence of gender, age and
employment status on personal attitudes toward seasonal influenza
immunization. Results. The study included 160 examinees, 74 (46.2%) men and
86 (53.8%) women, average age of 63 years. There were 88 (55%) employed and
72 (45%) unemployed participants. Of 160 participants, 113 (72.4%) had a
positive attitude toward vaccination, 20 (12.8%) had a negative attitude,
while 23 (14.7%) respondents were undecided. No statistically significant
difference was established between the sexes in attitudes toward
immunization. Vaccination coverage was higher in unemployed compared to
employed subjects (75% vs. 59.1%; p < .05). Unemployed respondents were more
regularly vaccinated than the employed examinees (66.1% vs. 46.7%; p < .05).
Conclusion. Higher vaccination coverage rates for planned immunizations
against seasonal influenza can be achieved through better promotion
strategies and health education of the population.
Chronic subdural hematoma - diagnosis, treatment and perspectives
Authors: Jukovic Mirela , Till Viktor
Published: April 2021

Introduction. Chronic subdural hematoma has become an important entity in
radiological, neurological and neurosurgery practice. Classification. The
classification of chronic subdural hematoma is most often done in relation
to the time of the disease onset (acute, subacute and chronic), whereas the
second classification is based on hematoma density using computed
tomography. Clinical presentation. The clinical presentation may mimic a
spectrum of various diseases and chronic subdural hematoma can be easily
overlooked without radiological verification. Diagnosis. The diagnosis of
chronic subdural hematoma is partly clinical and partly radiological. In
most cases, computed tomography is the initial diagnostic method for
detection of this disease. Many studies point to different management
strategies in the diagnosis and treatment of the disease. Therapy. The
therapy of chronic subdural hematoma depends on the patient?s neurological
deficit, but generally it is divided into conservative and surgical
treatment. Conclusion. The aim of this paper is to review chronic subdural
hematomas with reference to their clinical and radiological characteristics
for better understanding of these phenomena.
Source-to-sea and landscape approaches: integrating water quality and biodiversity conservation towards the restoration of the Rio Doce watershed
Authors: Brito M.C.W. , Barbosa F.A.R. , May P. , Maroun C. , Renshaw J. , Sánchez L.E. , Kakabadse Y.
Published: April 2021

The report contextualises the current status of water quality and biodiversity in the Rio Doce watershed, providing selected data and information on the physical, chemical and biological quality of the water and an overview of the terrestrial, freshwater and marine biodiversity since the dam rupture. A review of the integrated approaches already adopted in the Rio Docerestoration actions is also provided, focusing mainly on the TTAC programmes that in some respect embody the source-to-sea and landscape approaches in their conception. The Technical Report suggests pathways toward building a combined approach to restore water quality and biodiversity in the Rio Doce watershed, taking advantage of such actions already implementedby Renova Foundation and its partners.
Equity in music education in Finland: A policy window opened through the case of “Figurenotes”
Authors: Kivijärvi Sanna , Rautiainen Pauli
Published: April 2021

This article illustrates how a social innovation, Figurenotes, has contributed and can contribute,through conceptual change, to the advancement of equity in Basic Education in the Arts (BEA),Finland’s publicly funded system of extracurricular music education. BEA has traditionally beencharacterised by structures and pedagogical practices–such as the use of Western standard musicnotation–that influence the accessibility of music studies. The theoretical framework for this interviewstudy consists of change-theoretical concepts: namely, social innovation, multiple streams, andpolicy windows. The findings are presented at two levels. First, the innovation process of Figurenotesis described to explain social innovation development. Second, three different strands of discourseon the concept of special music education expose the educational policy change generated by thisinnovation. The findings suggest that the use of Figurenotes has raised awareness of inequity in theinstitutional agenda and has encouraged this problem to be addressed through the public policyprocess. The opening of this policy window is critically discussed in relation to the establishmentof the field of special music education, and in relation to inclusion and equity policies as well asexclusion.
A quarta Presidência portuguesa do Conselho da União Europeia
Authors:   ISEG, Amaral João Ferreira do
Published: April 2021

This paper discusses some of the issues on the agenda of the Portuguese presidency of the European Union and based on the experience of former Portuguese presidencies debates the dilemma of promoting national interests against the permanent pressure for centralization and implementation of uniform policies by the European Commission.
A Presidência rotativa do Conselho e a governança multinível europeia: a peça-chave no processo de decisão intergovernamental
Authors:   Berlin School of Economics and Law, Magone José
Published: April 2021

In the post-Lisbon constitutional architecture, the rotating presidency of the Council of Ministers of the European Union remains a vital part of intergovernmental decision-making. Its leadership activity is mainly behind closed doors to avoid the politicization of legislative processes. This study aims to contextualize the presidency as a crucial part of European integration due to its position between formal and informal processes. Informality gives the presidency time to create consensus and be flexible in its negotiation. Despite large countries’ attempts to reduce the importance of the rotating presidency, small states have resisted this temptation. In this contribution, the rotating presidency is seen from the point of view of European integration theory which is discussed in depth. Some notes follow on what can be expected in terms of the behaviour of the German and Portuguese presidencies in the new 2020-21 team presidency cycle.
Agência de paz sustentável e migrantes vulneráveis: o caso da empresa Electrolux como agente de desenvolvimento para a paz positiva
Authors:   Universidade Estácio de Sá, Souza Ana Luiza da Gama e , Costa Lara Denise Góes da ,   Escola Superior de Guerra /Ministério da Defesa
Published: April 2021

Before the global migration crisis, public policies in Brazil have proven to be insufficient to guarantee vulnerable migrant´s access to basic rights, especially the right to decent work. In this gap, companies, due to their economic power and the social impact of their practices, can be agents of sustainable peace, contributing to these people’s access to the formal labor market. This article proposes to analyze the Electrolux corporate practice of training and hiring refugees in Manaus, as a corporate agency for peace, to assess their social impact, as a potential to guarantee the right to work for these people.
Bilincin Akademik Gelişiminde Seyr-ü Süluk: Yakaza - Uyanış - Özgürlük
Authors: Yüksel Atila
Published: April 2021

Doktora süreci ve sonrasında, beslendiği akademik habitata bağlı lakin sonradan verilen zorunlu unvandan bağımsız (profesör, doçent vb) akademik gelişimin, olgunlaşmanın seyrinde akıl, mantık, düşünme biçimi, anlayış seviyeleri ve gayeleri açısından farklılaşabilen “bilinci” değişik mertebelere oturtmak, hallerle anmak mümkündür. Akademik gelişim sürecinde terim, model, konsept, teoriler hakkında alandan genelde pasif biçimde öğrenme devam ederken sadece öğrenme değil düşünme yeteneğinin de gelişmesi beklenir.
Novo Mundo em Odontologia pós COVID-19
Authors: de Almeida Juliana Silveira , da Silva Allyssia Vitória Souza , Correa Ana Karina Fonseca de Carvalho Calderan
Published: April 2021

The purpose of this work is to evaluate, through a recent bibliographic review, the main clinical characteristics of the disease caused by the new coronavirus (COVID-19), its routes of transmission and to address how the Surgeon - Dentist (CD) can identify the suspected patients and , mainly, to present preventive measures of biosafety in order to control and to minimize the contagion of this infection in the dental service. The new normal will need adaptations of dental techniques and new general recommendations, which will be part of everyday life from now on. A bibliographic search was performed in the PUBMED database with the keywords: Coronovirus, Biosafety and Dentistry, Covid-19, between January and April 2020. Articles with full versions, in English, Portuguese, and Spanishi were used as inclusion criteria.
Histone demethylases JHDM1D, PHF2 and PHF8 expression pattern in granulosa cells obtained from patients undergoing IVF procedure during short-term IVC
Authors: Bryl Rut , Stefańska Katarzyna , Chermuła Błażej , Stelmach Bogumiła , Pieńkowski Wojciech , Kulus Jakub , Perek Joanna , Wieczorkiewicz Maria , Wąsiatycz Grzegorz , Ratajczak Kornel , Pawelczyk Leszek , Mozdziak Paul , Jeseta Michal , Spaczyński Robert Z. , Bukowska Dorota
Published: April 2021

Granulosa cells play an important role in follicle development, maturation, and atresia. They are a cellular source of the two most important ovarian steroids, namely, estradiol and progesterone and are also crucial for bidirectional communication with the oocyte, thus being involved in the regulation of its growth, development and function. Growing body of evidence suggests that granulosa cells cultured in vitro display stemness and transdifferentiation potential. Together with the fact that they can be easily collected during IVF procedures, these properties of GCs may be of particular interest for both regenerative medicine and transplantology. Establishment of in vitro cell culture and its thorough characterization, including molecular, is crucial for future potential utilization of human granulosa cells in design of engineered tissue grafts or cell-based therapies, in particular targeted at female infertility. Nevertheless, the transcriptomic alterations which may occur during in vitro culture of granulosa cells are still largely uncharacterized. The aim of this study was to examine expression changes of three genes encoding histone demethylases which serve as transcription coactivators in short term in vitro cell culture of human granulosa cells. The study groups consisted of 14 patients, aged 18–40 years undergoing in vitro fertilization (IVF). Expression level assessment was performed after 24 h, 48 h, 72 h, 96 h, 120 h, 144 h and 168 h of in vitro primary cell culture utilizing RT-qPCR technique. Upregulation of PHF2 expression in all time points of the culture was observed, whereas the tendency of JHDM1D and PHF8 was mainly to decrease in expression level. Further study on a larger population would be required in order to confirm the presented tendencies.

Running title: Expression pattern of selected histone demethylases in human granulosa cells
Increased transcript expression levels of DNA methyltransferases type 1 and 3A during cardiac muscle long-term cell culture
Authors: Nawrocki Mariusz J. , Bryl Rut , Kałużna Sandra , Stefańska Katarzyna , Stelmach Bogumiła , Jemielity Marek , Perek Bartłomiej , Bukowska Dorota , Mozdziak Paul , Petitte James N. , Kempisty Bartosz
Published: April 2021

Heart failure (HF) is one of the main causes of death worldwide. Recent studies reported altered DNA methylation in failing human hearts. This may suggest a role of DNA methylation, most frequently implicated in epigenetic control, in the development of heart failure. Here, employing RT-qPCR, we characterized transcript levels for main DNA methyltransferases (DNMTs), DNMT1, DNMT3A, and DNMT3B, mediate DNA methylation, and they have different functions that complement each other during methylation. All analyzes were performed at different stages of porcine myocardial cell primary culture. In the present study we demonstrated increasing transcript expression levels for all analyzed genes during in vitro cultivation. The changes for DNMT1 and DNMT3A seem to be particularly important, where statistically significant changes were observed.

Running title: DNMTs role in cardiac muscle cell culture
Piperazine sulfonamides as DPP-IV inhibitors: Synthesis, induced-fit docking and in vitro biological evaluation
Authors: Khalaf Reema Abu , Alwarafi Ebtisam , Sabbah Dima
Published: April 2021

Diabetes mellitus is a chronic illness that needs persistent medical attention and continuous patient self-management to avoid acute complications. Dipeptidyl peptidase-IV (DPP-IV) inhibitors minimize glucagon and blood glucose levels by increasing the incretin levels, glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic poly-peptide (GIP), leading to insulin secretion from pancreatic beta cells. In the present study, nine 1,4-bis(phenylsulfonyl) piperazine derivatives 1a-i were synthesized and identified using 1H NMR, 13C NMR, MS and IR spectroscopies. These compounds were tested in vitro and showed inhibitory activity ranging from 11.2 to 22.6 % at 100 µmol L–1 concentration. Piperazine sulfonamide derivatives were found to be promising DPP-IV inhibitors, where the presence of electron-withdrawing groups such as Cl (1a-c) improved the activity of the compounds more than electron-donating groups such as CH3 (
1d-f) at the same position. Additionally, meta-substitution is disfavored (1b, 1e, 1g). Induced-fit docking studies suggested that the targeted compounds 1a-i occupy the binding domain of DPP-IV and form H-bonding with the backbones of R125, E205, E206, F357, K554, W629, Y631, Y662 and R669.
Determination of penicillamine, tiopronin and glutathione in pharmaceutical formulations by kinetic spectrophotometry
Authors: Kukoc-Modun Lea , Biocic Maja , Radić Njegomir
Published: April 2021

A novel and simple method for the determination of penicillamine (PEN), tiopronin (mercaptopropionyl glycine, MPG) and glutathione (GSH) in pharmaceutical formulations by kinetic spectrophotometry has been developed and validated. It is based on the redox reaction where the thiol compound (RSH) reduces CuII-neocuproine complex to CuI-neocuproine complex. The non-steady state signal of the formed CuI- neocuproine complex is measured at 458 nm. The initial rate and fixed time (at 1 min) methods were validated. The calibration graph was linear in the concentration range from 8.0 × 10‒7 to 8.0 × 10‒5 mol L−1 for the initial rate method and from 6.0 × 10‒7 to 6.0 × 10−5 mol L−1 for the fixed time method, with the detection limits of 2.4 × 10−7 and 1.4 × 10‒7 mol L−1, resp. Levels of PEN, MPG and GSH in pharmaceutical formulations were successfully assayed by both methods. The advantages of the presented methods include sensitivity, short analysis time, ease of application and low cost.
New derivatives of sulfonylhydrazone as potential antitumor agents: Design, synthesis and cheminformatics evaluation
Authors: Sabbah Dima A. , Al-Azaideh Bara’a A. , Talib Wamidh H. , Hajjo Rima , Sweidan Kamal , Al-Zuheiri Aya M. , Sheikha Ghassan Abu , Shraim Sawsan
Published: April 2021

Phosphoinositide 3-kinase α (PI3Kα) is a propitious target for designing anticancer drugs. A series of new N’-(diphenylmethylene)benzenesulfonohydrazide was synthesized and characterized using FT-IR, NMR (1H and 13C), HRMS, and elemental analysis. Target compounds exhibited an antiproliferative effect against the human colon carcinoma (HCT-116) cell line. Our cheminformatics analysis indicated that the para-tailored derivatives [p-NO2 (3) and p-CF3 (7)] have better ionization potentials based on calculated Moran autocorrelations and ionization potentials. Subsequent in vitro cell proliferation assays validated our cheminformatics results by providing experimental evidence that both derivatives 3 and 7 exhibited improved antiproliferative activities against HCT-116. Hence, our results emphasized the importance of electron-withdrawing groups and hydrogen bond-acceptors in the rational design of small-molecule chemical ligands targeting PI3Kα. These results agreed with the induced-fit docking against PI3Kα, highlighting the role of p-substituted aromatic rings in guiding the ligand-PI3Kα complex formation, by targeting a hydrophobic pocket in the ligand-binding site and forming π-stacking interactions with a nearby tryptophan residue.