bluuebunny/crossref_metadata_2025 huggingface dataset:
LIDOCAINE AS COMPONENT OF ANALGOSITION DURING CORONARY ARTERY STENTING
Authors: Dziuba D.A.
Published: January 2021

Minimally invasive techniques are one of the main methods for the diagnosis and treatment of coronary artery disease. Opiates are the main drugs that used for analgesia during interventional procedures, but their wide application is associated with a number of drawbacks. One of the ways to reduce the use of opiates is the concept of "multimodal anaesthesia", and one of its options is "no and low-opiate" anaesthesia. The aim of the presents study is to determine the main aspects of the lidocaine-based low and opiate-free anaesthesia during coronary artery stenting. 90 patients with coronary artery disease who underwent elective coronary artery stenting were included in the study. The patients were evenly divided into three groups, depending on the drugs used for intraoperative analgosedation. The first group (comparison) consisted of patients who received analgosedation with diazepam and fentanyl. For the non-opiate anaesthesia second group, the dosed lidocaine solution was the main component of analgesia. In order to study low-opiate analgesia based on the use of lidocaine, we formed the thirds group. Fentanyl was administered for analgesia induction, and lidocaine was administered intraoperatively to maintain the level of analgesia in combination with fentanyl infusion. For sedation, propofol was given in the target dose to achieve Level III by RAMSEY for the second and third groups. Intravenous use of lidocaine as a component of “low and no-opiate” anaesthesia is safe for coronary stenting operations. The study showed that the use of the above doses of lidocaine in comparison with traditional administration of opiates in assessing the parameters of external respiration, hemodynamics, and blood glucose and cortisol levels has a number of advantages and, at the same time, there are no negative effects typical for traditional anaesthesia. In comparison with the control group and the group of non-opiate anaesthesia, there are a smaller number of complaints of chest pain, drowsiness and numbness in the group of low-opiate anaesthesia in post-operative period.
STUDY OF THE EFFICIENCY OF ALLERGEN IMMUNOTHERAPY IN PATIENTS WITH ALLERGIC RHINITIS
Authors: Zubchenko S.O.
Published: January 2021

Allergen immunotherapy is one of the effective treatments for many allergic diseases. The principle of allergen immunotherapy is to achieve tolerance to causative allergens. The effectiveness of allergen immunotherapy depends on the correct diagnostic approach, the quality of the vaccine and patient compliance.

This article presents the analysis of the effectiveness of the allergen immunotherapy using sublingual and subcutaneous methods of administration in patients with allergic rhinitis. The study group consisted of 236 patients with allergic rhinitis, 126 (53.4%) female and 110 (46.6%) male individuals aged 32.6 ± 2.4 years. Clinical and laboratory data collection, instrumental, cytological, specific allergological studies (total IgG4, skin prick-tests, molecular studies ALEX) were carried out. The efficacy of the аllergen immunotherapy was assessed by a combined symptom medication score. According to the results of skin prick-tests, it was determined that 163 (69.0%) people had polysensitization, 61 (25.8%) individuals had monosensitization, and 12 (5.2%) had negative skin prick-tests. ALEX component studies were performed for 52 people. The most common major components found were Phl p 1, 69.2%, Lol p 1, 57.7%, Der f 2, 48.1%, Der p 2, 42.3%, Bet v 1, 34.6 %. Minor components Phl p 7, Phl p 12 were detected in 9 (17.3%) patients. According to molecular studies, the prognostic efficiency of the аllergen immunotherapy was defined as high in 41 people and as average in 9 people; 86 patients with allergic rhinitis took the allergen immunotherapy: 37 people by sublingual route, and 49 people by subcutaneous methods. There was a significant decrease in the overall assessment of symptoms, medication needs, and a comprehensive assessment that did not depend on the method of administration of the allergy vaccine. Comparative analysis of total IgG4 levels before and in the third year of the allergen immunotherapy showed only a tendency to increase (p = 0.492). The component-resolved diagnosis plays an important role in choosing a treatment strategy for patients with allergy and predicting the efficacy of the allergen immunotherapy. Allergen immunotherapy, regardless of the methods of its introduction, shows high clinical efficacy in patients with allergic rhinitis that was confirmed by the criteria of combined evaluation. Assessment of total IgG4 levels has not had a reliable diagnostic value as a biomarker of the immunological response to the allergen immunotherapy.
DYNAMICS OF THE MALONDIALDEHYDE LEVELS IN EXPERIMENTAL DIABETIC RETINOPATHY AND METHODS OF ITS CORRECTION
Authors: Sirman Y.V. , Savytskyi I.V. , Preys N.I.
Published: January 2021

Diabetes is currently considered a non-infectious epidemic. At the same time the main reason for the development of blindness in developed countries are pathological changes in blood vessels in eye diseases, primarily in diabetic retinopathy. The purpose of the study: analysis of changes in secondary products of lipid peroxidation in experimental diabetic retinopathy and in different ways of its correction. The study was performed on white Wistar rats weighing 180-200 g. According to the tasks, the animals were divided into 7 groups. Type 2 diabetes mellitus and diabetic retinopathy were simulated by intraperitoneal administration of streptozotocin (Sigma, USA) dissolved in 0.1 M citrate buffer with a pH of 4.5. The dose of streptozotocin 55 mg / kg body weight was divided into two injections. The introduction of streptozotocin was preceded by a high-fat diet for 28 days. Corrective agents used in the study: metformin, aflibercept, L-carnitine, bromfenac, L-arginine and citicoline.

The results obtained indicate an increase in the activity of lipid peroxidation, starting from the 30th and with subsequent progression to the sixtieth and one hundred and eightieth days of experimental diabetic retinopathy. This is confirmed by the increase in the level of malondialdehyde in the 2nd group, the maximum of which is observed at the third stage. Correction with hypoglycemic agents in the 3rd group had a positive effect, but was not able to reduce the level of secondary products of lipid peroxidation, so it became necessary to use additional agents. The use of aflibercept and a nitric oxide donor in the 4th group to correct the development of diabetic retinopathy significantly inhibited oxidative stress, the maximum of which occurred on the one hundred and eightieth day of the experiment, but did not reach the control values. It was proved that the combined administration of bromfenac and aflibercept in the 5th group significantly reduced the amount of LPO secondary products, but not as significantly as in the 4th group. It was proved that the administration of aflibercept, L-carnitine and bromfenac to animals of the 6th group reduced the content of LPO secondary products already on the 30th day and was prolonged on the 60th and 180th days of the study, but did not reach the control values ​​either.

The most effective correction was the combination of metformin, aflibercept, L-arginine and citicoline in rats of the 7th group, as evidenced by the normalization of the level of malondialdehyde on the thirtieth and sixtieth days of the experiment, and on the one hundred and eightieth a decrease in the content of the marker to the control values ​​was recorded.
Stilska
sredstva u funkciji oblikovanja lika idealnog bizantskog cara
Authors: Serreqi Jurić Teuta
Published: January 2021

Spis
Vita Basilii književna nam tradicija
donosi u sklopu literarnog korpusa bizantskog cara Konstantina VII. Porfirogeneta
(913. ‒ 959.). Radi se o vrsti pohvalnoga govora (βασιλικὸς λόγος) sastavljenog
u čast utemeljitelja Makedonske dinastije Bazilija I. (867. ‒ 886.), čija je
svrha bila osloboditi Porfirogenetova djeda od krivnje za ubojstvo njegova
prethodnika, cara Mihaela III. (842. ‒ 867.), što je ubrzalo Bazilijev dolazak
na vlast. Bazilije u spisu utjelovljuje sliku idealnog bizantskog cara, dok je
Mihael prikazan u negativnom kontekstu i kao primjer lošeg vladara. U radu se
analizira uloga stilskih sredstava u oblikovanju Bazilijeva i Mihaelova lika.
Iako je visoki stupanj upotrebe stilskih ukrasa u ovakvoj književnoj vrsti
očekivan, na temelju odabranih primjera predočit će se kako ih je u određenim
slučajevima autor ciljano upotrebljavao ne samo radi podizanja retoričkog
naboja, nego i s tendencijom da Bazilije unatoč mračnoj strani dolaska na
prijestolje bude prikazan kao „spasitelj” Bizantskog Carstva nakon Mihaelove
loše vladavine, a Mihael kao glavni krivac za svoju vlastitu smrt.
Odnos NOVJ-a prema hrvatskom stanovništvu i poraženim vojnicima oružanih snaga NDH-a u Mostaru krajem Drugoga svjetskoga rata i u neposrednom poraću
Authors: Mandić Hrvoje
Published: January 2021

Zauzimanjem Mostara NOVJ je uspostavio nadzor nad donjim tokom rijeke Neretve i ostvario jedan od dvaju preduvjeta za uspostavu revolucionarne komunističke vlasti na tom prostoru. Drugi preduvjet bio je obračun sa svim potencijalnim političkim protivnicima, odnosno klasnim neprijateljima u Mostaru. Problematika stradanja hrvatskoga stanovništva u veljači i neposrednom poraću 1945. godine u Mostaru nedovoljno je istražena. Komunističke vlasti svjesno su zanemarivale hrvatske civilne žrtve u veljači i poraću 1945. s pomoću režimske historiografije. Rad predstavlja doprinos istraživanju hrvatskih žrtava u Mostaru. U radu je korištena deskripcija, povijesno-narativna metoda, metoda analize sadržaja, metoda brojenja/nabrajanja i metoda oralne (usmene) povijesti. OZNA i KNOJ počinili su planski, provedbom metode razdavanja i likvidacije, niz ubojstava hrvatskoga stanovništva i pripadnika oružanih snaga NDH-a u Mos-taru u veljači te neposrednom poraću 1945. godine. Najveća stratišta pobijenih civila i vojnika nalaze se ispod partizanskoga spomenika u Mostaru, u jami Novakuša prema Nevesinju i lokalitetu Radimlja kod Stoca.
Odjeci hrvatskoga proljeća u Osijeku
Authors: Tomas Domagoj , Bošnjak Marijana
Published: January 2021

U članku se raščlanjuju zbivanja koja se mogu podvesti pod zajednički nazivnik hrvatskoga proljeća na lokalnom osječkom području. Pritom se u uvodnom dijelu polazi od terminološkoga i sadržajnoga određenja općega fenomena hrvatskoga proljeća, uz prepoznavanje nekolicine događaja koji su mu prethodili te omogućili razvoj. Zatim slijedi prijedlog periodizacije hrvatskoga proljeća s trima fazama te predstavljanje njegovih triju žarišta, s lokalnim osječkim ekvivalentima (»reformno« krilo OK-a SKH-a Osijek, OMH Osijek i SSO). U nastavku članka u pojedinačnim se poglavljima analiziraju zbivanja u okviru osječkih društveno-političkih organizacija, OMH-a Osijek i osječkoga student-skoga pokreta, koja se mogu staviti u kontekst hrvatskoga proljeća. Utvrđena je izravna povezanost proljećarskih gibanja u Zagrebu s onima koja će uslijediti u Osijeku, pomoću raznih uobičajenih komunikacijskih kanala, poput sudjelovanja članova CK-a SKH-a na sjednicama lokalnih društveno-političkih organizacija ili pak javnih predavanja istaknutih članova MH-a iz Zagreba u organizaciji OMH-a Osijek. Također, u konačnici se pokazalo da je stanje u Zagrebu dobrim dijelom bilo preslikano i na osječko područje u vrijeme kulminacije hrvatskoga proljeća, uzimajući u obzir društveno-političke organizacije, MH i studente, s jedinim izuzetkom nešto kasnije pojave proljećarskih ideja u Osijeku u odnosu na Zagreb.
Rancang Bangun Mesin Produksi Biodiesel Sistem Kontinyu Kapasitas 400 Liter/Jam
Authors: Suryanto Suryanto , Abadi Sukma , Amanah Barka , Wahyudin Wahyudin
Published: January 2021

Biodiesel merupakan salah satu jenis biofuel (bahan bakar cair dari pengolahan minyak nabati atau lemak hewani). Penggunaan biodiesel di Indonesia dalam dekade terakhir ini terus mengalami peningkatan sehingga sistem produksi biodiesel terus dikembangkan guna menghasilkan produk yang kontinyu, berkualitas dan efisien. Berdasarkan kondisi tersebut maka penelitian ini dilakukan untuk meningkatkan produksi biodiesel dengan merancang mesin produksi sistem kontinyu kapasitas 400 liter/jam menggunakan sistem kontrol seri Arduino Mega 2560 pada alat produksi sehingga diperoleh suatu sistem yang kontinyu dengan mengontrol secara otomatis. Hasil uji coba mesin produksi biodiesel dari penelitian ini diperoleh hasil kapasitas 117 liter/jam/tangki. Dari hasil tersebut diperoleh produk yang terdiri dari 12,5 liter gliserol sedangkan biodiesel 104,5 liter. Ada empat tangki yang bekerja secara sekuen sehingga diperoleh total kapasitas 420 liter/jam. Adapun dari hasil uji mutu biodisel yang telah diuji lab menunjukkan hasil yang sesuai dengan standar SNI.
Homecoming without Nostalgia: Local Communities and the Reintroduction of the Wild Forest Reindeer (Rangifer tarandus sennicus) in Finland
Authors: HiedanpÄÄ Juha , Pellikka Jani
Published: January 2021

Wildlife translocations often raise concerns about the purpose and impact among people living in target locations. We applied the integrated impact assessment in planning the reintroduction of wild forest reindeer in Finland. We investigated the variety of expected socioecological impacts, the relative importance of these impacts and local willingness to participate in local-level reintroduction activities. The reintroduction project organised interactive forums in 2013 and 2016 in each of the four regions suitable for wild forest reindeer. The variety of recognised potential impacts was high, but the relative importance given to the expected impacts varied relatively little from forum to forum. Importantly, we found a contextual and relational value of wild forest reindeer that extended beyond their intrinsic and instrumental value. The results indicate high local acceptance of reintroduction and willingness to participate in it.
Sleep and Tau Pathology in Vietnam War Veterans with Preclinical and Prodromal Alzheimer’s Disease
Authors: Andrews Murray , Ross Ryan , Malhotra Atul , Ancoli-Israel Sonia , Brewer James B. , Banks Sarah J. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: January 2021

Background:

The increasing prevalence of Alzheimer’s disease (AD) and lack of effective medications has led to a need to identify modifiable risk factors as targets for interventions.

Objective:

In this cross-sectional study, we sought to determine whether worse sleep quality is associated with increased pathological tau, and whether this relationship is affected by amyloid pathology.

Methods:

66 male participants underwent Florbetapir (AV45) positron emission tomography (PET) and Flortaucipir (FTP) PET and completed the Pittsburgh Sleep Quality Index questionnaire (PSQI) as part of the Department of Defense Alzheimer’s Disease Neuroimaging Initiative, a multicenter study collecting data from Vietnam War veterans, some of whom have a history of post-traumatic stress disorder, or non-penetrating traumatic brain injury. AV45 PET was used to determine the presence of significant amyloid pathology. We used regression models to determine the effects of amyloid pathology and PSQI on tau deposition in brain regions associated with Braak stages.

Results:

Among the 66 participants, 14 individuals were amyloid positive (21%) and 52 were amyloid negative (79%). In regions associated with Braak stages III-IV, there was a significant interaction of amyloid status on PSQI (β= 0.04, p = 0.003) with higher PSQI correlating with higher FTP SUVr in amyloid-positive individuals only (β= 0.031, p = 0.005).

Conclusion:

Our study found that an AD profile of tau deposition was associated with an interaction between self-reported sleep quality and amyloid pathology such that worse self-reported sleep was related to higher tau in regions usually associated with AD progression, but only in individuals with high cerebral amyloid deposition.
Early Bone Metastases are Associated with Worse Outcomes in Metastatic Urothelial Carcinoma
Authors: Nelson Ariel A. , Cronk Robert J. , Lemke Emily A. , Szabo Aniko , Khaki Ali R. , Diamantopoulos Leonidas N. , Grivas Petros , Nezami Behtash Ghazi , MacLennan Gregory T. , Zhang Tian , Hoimes Christopher J.
Published: January 2021

BACKGROUND:

Outcomes of patients with metastatic urothelial carcinoma (mUC) with early bone metastases (eBM) vs no early bone metastases (nBM) have not thoroughly been described in the age of immuno-oncology.

OBJECTIVE:

To compare survival and other clinical outcomes in patients with eBM and nBM.

METHODS:

We used a multi-institutional database of patients with mUC treated with systemic therapy. Demographic, metastatic site, treatment patterns, and clinical outcomes were recorded. Wilcoxon rank-sum, chi-square tests were performed. Survival was estimated by Kaplan-Meier method; multivariable Cox analysis was performed.

RESULTS:

We identified 270 pts, 67% men, mean age 69±11 years. At metastatic diagnosis, 27% had≥1 eBM and were more likely to have de novo vs. recurrent metastases (42% vs 19%, p < 0.001). Patients with eBM had shorter overall survival (OS) vs. those with nBM, (6.1 vs 13.7 months, p < 0.0001). On multivariable analysis, eBM independently associated with higher risk of death, HR = 2.52 (95% CI: 1.75–3.63, p < 0.0001). OS was shorter for patients with eBM who received initial immune checkpoint inhibitor vs platinum-based chemotherapy, (1.6 vs 9.1 months, p = 0.02). Patients with eBM received higher opioid analgesic doses compared to patients with nBM and received quantitatively more palliative radiation.

CONCLUSIONS:

Patients with mUC and eBM have poorer outcomes, may benefit less from anti-PD-1/PD-L1 therapy and represent an unmet need for novel therapeutic interventions. Dedicated clinical trials, biomarker validation to assist in patient selection, as well as consensus on reporting of non-measurable disease are required.
Augmented Reality for Human Needs: An Ontology
Authors: Yahya Manal A. , Dahanayake Ajantha
Published: January 2021

Augmented Reality is a display and interaction method of future computing. It augments digital information in real environments in text, audio, image, or video formats. Augmented reality can be more effective if supported by knowledge about human needs. Basic human needs are finite in number, and with the right methods, they are detectable or predictable. This research develops an ontology that describes the structure and relations between the elements of augmented reality, context information, and human needs, with the ultimate goal of developing a robust conceptual model. Ontology development is a knowledge-driven approach used to represent data and reasoning. This paper focuses on linking the aforementioned concepts to enable correct data representation and reasoning. The research approach, process used, and the evaluation of the ontology is presented as well.
A Mental Health Database Creation Method with Neuroscience-Inspired Search Functions
Authors: Raneva Venera , Kiyoki Yasushi
Published: January 2021

Mental health, an essential factor for maintaining a high quality of life, is determined by one’s nutritional, physical, and psychological situations. Since mental health is influenced by multiple factors, a multidisciplinary approach is effective. Due to the complexity of this mechanism, most non-specialists have little knowledge and access to the related information. There are multiple factors that influence one’s mental health, such as nutrition, physical activities, daily habits, and personal cognitive characteristics. Because of this complexity, it can be hard for non-specialists to find and implement appropriate methods for improving their mental health. This paper presents the 2-Phase Correlation Computing method for interpreting the characteristics of each emotion/mental state, nutrients, exercises, life habits with a vector space. The vector space reflects the roles of neurotransmitters. The 2-Phase Correlation Computing extracts the information expected to be most relevant to the user’s request. In this method, expert knowledge, characteristics of emotions, and mental states are defined in the “Requests” Matrix, and each stimulus into “Nutrients”, “Exercises”, and “Life Habits” Matrixes. “Nutrients”, “Exercises”, and “Life Habits” are expressed and computed to as “Stimuli”. In short, this method introduces logos to the chaotic world of decision making in mental health.
The Retinal Vessel Density Can Reflect Cognitive Function in Patients with Alzheimer’s Disease: Evidence from Optical Coherence Tomography Angiography
Authors: Yan Yibing , Wu Xingqi , Wang Xiaojing , Geng Zhi , Wang Lu , Xiao Guixian , Wu Yue , Zhou Shanshan , Liao Rongfeng , Wei Ling , Tian Yanghua , Wang Kai
Published: January 2021

Background:

There is increasing evidence that Alzheimer’s disease (AD) patients may present decreased cerebral blood perfusion before pathological brain changes. Using the retina as a window to the brain, we can study disorders of the central nervous system through the eyes.

Objective:

This study aimed to investigate differences in retinal structure and vessel density (VD) between patients with mild AD and healthy controls (HCs). Furthermore, we explored the relationship between retinal VD and cognitive function.

Methods:

We enrolled 37 patients with AD and 29 age-matched HCs who underwent standard ophthalmic optical coherence tomography angiography (OCTA) for evaluation of the retinal layer thickness and VD parameters. Cognitive function was evaluated using a battery of neuropsychological assessments. Finally, the correlations among retinal layer thickness, VD parameters, and cognitive function were evaluated.

Results:

The retinal fiber layer thickness and retinal VD of patients with AD were significantly reduced compared with HCs. The retinal VD was significantly correlated with overall cognition, memory, executive, and visual-spatial perception functions. However, there was no significant between-group difference in the macular thickness.

Conclusion:

Our findings indicate a positive correlation between retinal VD and some, but not all, cognitive function domains. Most importantly, we demonstrated the role of OCTA in detecting early capillary changes, which could be a noninvasive biomarker for early AD.
Effects of photoselective colour nets on the vegetative, productive, and qualitative behaviour of kiwifruit, jintao cultivar
Authors: Gullo Gregorio , Dattola Antonio , Vonella Vincenzo , Zappia Rocco
Published: January 2021

BACKGROUND: In the Mediterranean basin, the solar radiation received is very high for many tree species over several hours of the day during the summer. Using a photoselective net can improve the climatic conditions and also modify the quality of light received. OBJECTIVE: This study aimed to evaluate the influence of the colour of photoselective nets on the yield and quality of Actinidia chinensis. MATERIALS: The experiment was carried out in Southern Italy on an orchard of Jintao kiwifruit. Photoselective nets of different colours were used: black, red, yellow, white, and grey. The resulting fruits were compared to those of plants in the open field. A randomised block design was adopted. Environmental, vegetative, leaf gas exchange parameter, yield, and fruit quality were defined. All data were analysed using the Variance Analysis (ANOVA) and the Principal Component Analysis (PCA). RESULTS: Photoselectivity influenced production. The best results were obtained under the red net in terms of production and fertility indices. Fruit size, maturation indices, and nutraceutical parameters were also higher under the red net. Among the nets, the grey net induced the worst tree productivity results and the worst fruit quality parameters. However, all nets showed better results compared to the open field. CONCLUSION: The photoselective net strongly influenced the yield and quality of Jintao kiwifruit and the better results compared to the open field. The red net proved to be the best performer for the environment where the experiment was carried out.
A soft exosuit for hip extension assistance of the elderly
Authors: Fang Tao , Cao Wujing , Chen Chunjie , Zhang Yu , Wang Zhuo , Wu Xinyu
Published: January 2021

BACKGROUND: Population aging is now a universal trend. Many elderly persons can only conduct limited and short time walking because of age-related skeletal muscle decline of the lower limbs. The wearable device for walking assistance is beneficial to improve the life quality of the elderly. OBJECTIVE: This study aimed to propose a soft exosuit for walking assistance of the elderly and verify its feasibility. METHODS: The wearable structure and control strategy were presented. The performance of the soft exosuit was tested by force tracking evaluation and metabolic cost test. RESULTS: The mean error of the measured and target peak force was 1.1%. The metabolic cost with assistance on while wearing the exosuit was reduced by 9.2% compared with that in locomotion assistance off. The reduction of assistance on was 7.1% compared with no exosuit. CONCLUSIONS: The proposed soft exosuit has the potential to improve the walking efficiency of the elderly.
Effect of grape seed proanthocyanidins on activity of HaCaT cells in mice based on deep learning image processing
Authors: Xu Feng , Huang Jia
Published: January 2021

BACKGROUND: Grape seed proanthocyanidin extract (GSPE) has a certain resistance to contrast light, which makes the boundary of the imaging image unclear. OBJECTIVE: Because of this, an image processing algorithm is needed to process the contrast image to study the role of GSPE in the process of anti-ultraviolet. METHODS: In this paper, the fuzzy edges of contrast images were processed by deep learning algorithm, and the changes of VEGF and PEDF expression in HaCaT cells before and after UVA irradiation and after GSPE intervention were studied. RESULTS: The experiment results show that after processing, the edge and boundary of the image become clear and separable, which can be used to compare and analyze the test process. The image comparison results show that GSPE can down regulate the expression of VEGF gene and protein, and up regulate the expression of PEDF gene and protein. The synergistic effect of GSPE and GSPE can inhibit angiogenesis. It is confirmed that GSPE has the effect of anti-ultraviolet ray induced early angiogenesis.
Kajian Literatur Parameter Proses Reduksi Selektif Bijih Nikel Laterit
Authors: Nurjaman Fajar , Bahfie Fathan , Herlina Ulin , Astuti Widi , Suharno Bambang
Published: January 2021

Proses reduksi selektif bijih nikel laterit merupakan salah satu metode pirometalurgi yang dilakukan dengan mereduksi senyawa besi dan nikel oksida dalam bijih nikel laterit pada temperatur 1100-1200°C menjadi logam ferronikel dengan membatasi metalisasi besi melalui penambahan aditif dan penggunaan jumlah reduktan yang terbatas. Kandungan dan perolehan  nikel dalam konsentrat semakin meningkat dengan semakin banyaknya aditif yang ditambahkan. Namun penambahan aditif dalam jumlah banyak akan meningkatkan biaya produksi proses reduksi selektif tersebut. Penggunaan reduktan batubara dengan kandungan sulfur tinggi memungkinkan untuk mensubstitusi penggunaan aditif. Proses reduksi selektif tidak hanya melibatkan reaksi solid-state melainkan juga melibatkan reaksi solid-liquid state. Oleh karena itu biaya produksi proses reduksi selektif juga dapat diminimalkan  melalui penggunaan basisitas yang optimal sehingga diperoleh kondisi proses dengan titik lebur fasa metalik dan non-metalik yang rendah. Dengan konsumsi energi/temperatur reduksi yang lebih rendah, diharapkan teknologi reduksi selektif bijih nikel laterit mampu menggantikan teknologi pirometalurgi konvensional (blast furnace dan rotary kiln electric arc furnace). Teknologi ini juga diharapkan mampu menjadi solusi permasalahan terkait pengolahan bijih nikel laterit kadar rendah (<1,7% Ni) yang ketersediaannya sangat berlimpah di dunia, dimana nilai keekonomisan yang diperoleh akan sangat rendah jika menggunakan teknologi pirometalurgi konvensional.
Infliximab-associated pulmonary tuberculosis
Authors: Donel González Díaz Donel , Merino Peralta Carlos , Fernández García Sergio
Published: January 2021

Tumor necrosis factor alpha antagonist drug therapy has been beneficial in the treatment of several diseases such as connective tissue and inflammatory bowel diseases, but it is not without risks. The main complications of these immunosuppressive drugs are infections, and pulmonary tuberculosis is one of the main conditions, which can be observed in patients with this type of treatment. A 31-year-old woman, treated at the Hermanos Ameijeiras Clinical Surgical Hospital, Havana, Cuba, with a history of ulcerative colitis, who has been receiving infliximab therapy for 3 months, presented. He went to the hospital for referring 4 days prior to admission, a fever of 390 C twice a day, accompanied by headache, loss of appetite and pain in the perineal region. A chest X-ray was performed, which described heterogeneous radiopacity that goes from the upper horn of the right hilum to axillary planes, in the chest axial tomography they report consolidation in the anterior segment of the right upper lobe with the presence of air bronchogram and in the bronchial lavage microbiological for acid-fast bacilli coding 8, positive for mycobacterium tuberculosis was reported. Accurate diagnosis of tuberculosis related to the use of tumor necrosis factor alpha antagonist drugs requires a high index of suspicion and detailed investigation. There is a high degree of diagnostic complexity, due to the existence of a wide clinical spectrum and the need to exclude other diseases.
Rekayasa Perangkat Lunak Performance Indicator dalam Penentuan Penilaian Karyawan dengan Metode Simple Additive Weighting
Authors: Yansen Yansen , Fauziah Zifa , Ananda Yesica Wisda , Yulianti Yulianti
Published: January 2021

Employee appraisal is an important factor in the development of a company effectively and efficiently because employee appraisal is one of many indicators in measuring the background of human resources system in the company. Determining the right indicators of human resources can motivate better employee performance. To support this kind of system, a software engineering with Performance Indicator system is needed and data collection techniques by direct observation and data documentation are needed. Application of engineering Key Performance Indicator software for employee performance appraisal using the Simple Additive Weighting method can result in the efficiency of the assessment process in determining the quality of an employee's performance. as well as assisting employees in knowing the results of performance evaluation, and making it easier for supervisors to obtain reports on sales performance ratings so that superiors can and make determine the amount of salary, commision and bonus increases more precisely and efficiently.
Challenges of Gender Policy Implementation in the Security and Defense Sector
Authors: Цукан О. М. , Бурдін М. Ю.
Published: January 2021

The authors of the article have studied the problems of ensuring the principles of gender equality in the free trade sector of the security and defense sector. Aspects of gender equality have a special role in ensuring the educational process, managing the free economic zone and overcoming stereotyping of society, especially in the security and defense sector. It is extremely important to ensure the implementation of the principles of gender equality for the formation of a gender-neutral environment in the power sector of the state. This situation is possible only with the use of an integrated approach to equal opportunities for women and men to realize equal rights. The analysis of gender approaches used in free economic education with specific learning conditions on the example of Kharkiv National University of Internal Affairs made it possible to recommend to use best practices of international experience to accelerate the pace and quality of gender implementation at the University. The authors analyze all the activities of the University, which are aimed at ensuring the implementation of the principles of gender equality: institutional change, personnel component, academic disciplines, scientific and educational work of staff, projects, involvement of the international component.

It has been concluded that higher educational institutions with specific learning conditions launched a comprehensive approach to ensure the implementation of the principles of gender equality both by the University administration and in educational and research activities. However, summarizing the above, it is necessary to emphasize the need to gain international experience to accelerate the pace and quality of gender at the University. Information support from international experts ensures more successful implementation of the principle of gender equality and overcoming gender stereotypes, which are obstacles to building a gender-balanced society.
State of Art
Authors: Dolenec Sanja , Vodeb Ksenija
Published: January 2021

Turistička valorizacija baštine konflikata može potaknuti pomirbu, ali i nove sukobe. Ciljevi su rada produbiti razumijevanje interesa dionika i učinaka interesa dionika na održivost oblika turizma denotiranog u korpusu literature konstruktom „mračni turizam“. Pregled literature objavljene od 2011. do 2019. u renomiranim bazama podataka, izabrane metodama integrativnog pregleda i teorijskog okvira održivosti prema teoriji dionika, upućuje na zaključke da: (1) je svaki primjer mračnoga turizma jedinstven glede održivosti prema teoriji dionika, (2) relativno održiv mračni turizam čuva posebno ozračje i integritet lokaliteta; propitkuje prikladnost njegova razvoja; uključuje relevantne dionike, nosi im koristi i konstantno uvažava njihovu osjetljivost; lokalnu zajednicu i turiste smatra najosjetljivijim dionicima koji mogu uključivati žrtve, njihove nasljednike te ostale povezane s tragedijom; osvještava društvo o sprečavanju tragedija; usklađen je s vladajućom politikom. Ove bi znanstvene spoznaje trebale doprinijeti razumijevanju osnova održivosti mračnoga turizma te pospješiti formuliranje strategija održivog upravljanja mračnim turizmom koje potiče pomirbu u postkonfliktnim društvima.
Tipo da lei moral na crítica da razão prática
Authors: Neto Silvio Couto , Candiotto Cesar
Published: January 2021

No presente trabalho pretende-se fazer uma abordagem sobre a questão do tipo da lei moral como tratado por Immanuel Kant em sua obra Crítica da Razão Prática, buscando-se um enfoque explicativo sobe tal ponto e, naquilo que se mostrar possível, uma comparação ao tipo penal, utilizado na teoria do direito penal; isso porque o tipo da lei moral tem propósito semelhante ao tipo da lei moral, qual seja, possibilitar a compreensão da lei. A lei moral – que é totalmente isenta de influência de qualquer elemento natural, sensível, ditada unicamente pela razão livre e a priori, sem condicionantes externos – poderá ser compreendida, a partir do tipo através de modelos existentes no mundo natural, fenomênico, elementos, por isso mesmo, concretos e sensíveis.
ANALISA LOKASI DAN PELAYANAN TERHADAP TIMBULNYA WORD OF MOUTH (WOM)
Authors: Kusmiran Ade , Syahlan Syahlan , Muniroh Leny
Published: January 2021

Penelitian ini bertujuan untuk mengetahui analisa lokasi dan pelayanan terhadap timbulnya word of mouth (wom) pada Klinik Nirwana Medical Centre palabuhan ratu kabupaten sukabumi.Jumlah sampel yang digunakan pada penelitian ini adalah 91 responden. Pengambilan sampel menggunakan nonprobability sampling.Teknik pengumpulan data dengan kuesioner.Analisis data menggunakan teknik analisis regresi berganda. Hasil penelitian menunjukkan bahwa lokasi berpengaruh parsial dan signifikan terhadap timbulnya word of mouth (sig.0,006 ), kontribusinya sebesar 31,3 %, pelayanan berpengaruh parsial dan signifikan terhadap timbulnya word of mouth (sig.0,003), kontribusinya sebesar 33,3 %, lokasi dan pelayanan berpengaruh simultan (bersama-sama) secara signifikan terhadap timbulnya word of mouth (sig.0,000), kontribusinya sebesar 33,9 %.
ANALISIS PERBANDINGAN KINERJA KEUANGAN SEBELUM DAN SESUDAH PERUBAHAN DARI BADAN USAHA BERBADAN HUKUM
Authors: Cholillah Syifa , Nurhayati Immas , Supramono Supramono
Published: January 2021

Tujuan dilakukannya penelitian ini adalah guna mengetahui adakah perbedaan hasil kinerja keuangan perusahaan sebelum dan sesudah pergantian lembaga, apakah pengelolaan keuangan perusahaan tersebut menjadi lebih baik, menurun, ataukah fluktuatif pada periode 2011-2013 dan 2014-2016. Kinerja keuangan perusahaan merupakan cerminan karakter perusahaan. Kinerja keuangan yang baik berpengaruh terhadap nilai perusahaan sebagai manifestasi yang baik dalam pengelolaan sumber daya yang ada pada perusahaan tersebut, pada penelitian kali ini digunakan penilaian terhadap faktor-fakor likuiditas, solvabilitas, dan profitabilitas. Berdasarkan analisis terhadap PT Jamsostek Ketenagakerjaan dan BPJS Ketenagakerjaan, didapat Current Ratio terbaik pada dua badan usaha tersebut yakni di tahun 2011 untuk PT Jamsostek sebesar 104,69% dan untuk untuk BPJS di tahun 2015 yakni 799,89%. Dilihat dari rasio Cash Ratio rata-rata terbaik terjadi di tahun 2013 yakni 0,78% untuk PT Jamsostek dan untuk BPJS di tahun 2014 yakni 136,61%. Hasil untuk rasio solvabilitas; debt to total assets kinerja terbaik selama 2011-2013 adalah di tahun ketiga yakni sebesar 95,87%. Sedangkan kinerja terbaik BPJS berada di tahun 2016 yakni 22,03% . Debt to total equity terbaik Jamsostek adalah tahun 2012 yakni 1999,10% walaupun hasil yang ditunjukkan masih sangat fantastis dan jauh di atas rata-rata standar industri, sedangkan untuk BPJS terbaik di tahun 2015 yakni 24,32%. Untuk rasio profitabilitas; ROI PT Jamsostek menunjukkan hasil yang kurang baik yakni hanya rata-rata sekitar 1,60% sedangkan BPJS menunjukkan rata-rata ROI sebesar 6,61%. ROE PT Jamsostek menunjukkan hasil yang cukup baik yakni dengan rata-rata 37,06% sedangkan untuk BPJS hanya sekitar 8,33%. Dari hasil analisis kinerja keuangan disimpulkan bahwa kinerja BPJS Ketenagakerjaan cenderung lebih baik dibandingkan dengan kinerja PT Jamsostek Ketenagakerjaan dilihat dari perubahan menggunakan Metode Indeks.
PENGARUH TINGKAT INFLASI, KURS, DAN SUKU BUNGA BANK INDONESIA TERHADAP INDEKS HARGA SAHAM
Authors: Fikri Ali , Suharti Titing , Yudhawati Diah
Published: January 2021

Penelitian ini dilakukan untuk mengetahui pengaruh Inflasi, Kurs dan Suku Bunga Bank Indonesia periode tahun 2008 – 2018. Populasi penelitian ini adalah Bank Indonesia, Badan Pusat Statistik, Bursa Efek Indonesia. Variabel yang digunakan dalam penelitian ini adalah Inflasi, Kurs, dan Suku Bunga Bank Indonesia sebagai variabel independen; Indeks Harga Saham Gabungan sebagai variabel dependen. Analisis data yang digunakan untuk menguji hipotesis dalam penelitian ini adalah analisis regresi sederhana, analisis regresi linier berganda, analisis koefisien korelasi, analisis koefisien determinasi dan uji hipotesis. Hasil penelitian ini menunjukkan bahwa (1) Inflasi secara parsial tidak berpengaruh secara signifikan terhadap Indeks Harga Saham Gabungan. (2) Kurs secara parsial berpengaruh secara signifikan terhadap Indeks Harga Saham Gabungan. (3) Suku Bunga Bank Indonesia secara parsial tidak berpengaruh secara signifikan terhadap Indeks Harga Saham Gabungan. (4) Inflasi, Kurs dan Suku Bunga Bank Indonesia secara simultan berpengaruh secara signifikan terhadap Indeks Harga Saham Gabungan
PENGARUH LINGKUNGAN KERJA, DAN MOTIVASI KERJA, TERHADAP PRESTASI KARYAWAN
Authors: Rahayu Anita , Agung Syahrum , Subakti Jani
Published: January 2021

Penelitian ini ditujukan untuk mengetahui pengaruh Lingkungan kerja, dan Motivasi kerja, terhadap Prestasi karyawan. Penelitian ini dilakukan pada 60 orang karyawan pada perusahaan swasta di Bogor. Penelitian ini dilakukan dengan menggunakan data Primer, yaitu dengan penyebaran Kuisioner. Metode analisis data yang digunakan meliputi Uji Validitas, Uji Realibilitas, Uji Regresi, Analisis korelasi, Koefisien determinasi, Uji asumsi klasik, dan Uji hipotesis. Hasil penelitian secara parsial terhadap Lingkungan kerja menunjukan nilai signifikan 0,211 ini berarti Lingkungan kerja tidak berpengaruh secara positif terhadap Prestasi karyawan. Untuk hasil Motivasi kerja menunjukan hasil nilai signifikan sebesar 0,001 hasil ini menunjukan bahwa Motivasi kerja berpengaruh secara Positif terhadap Prestasi karyawan secara parsial. Dan hasil Uji f simultan diperoleh f hitung sebesar 7,621  f tabel sebesar 3,16 dan dengan tingkat signifikan dibawah 0,05 yaitu 0,001. Dengan demikian Hipotesis Ho ditolak dan Ha diterima artinya variabel Lingkungan kerja, dan Motivasi kerja berpengaruh secara simultan terhadap Prestasi kerja.
ANALISIS RISK PROFILE, EARNING DAN CAPITAL UNTUK MENILAI KESEHATAN BANK
Authors: Fatikasari Cindy Ida Ayu , Suharti Titing , Aminda Renea Shinta
Published: January 2021

Penelitian ini bertujuan untuk mengetahui tingkat kesehatan bank, serta untuk mengetahui rasio berdasarkan risk profile, erning dan capital menggunakan analisis laporan keuangan tahunan. Bank yang sehat adalah bank yang dapat menjaga dan memelihaara kepercayaan masyarakat, dapat menjalakan fungsi intermediasi, membantu memperlancar pembayaran serta digunakan oleh pemerintah dalam melaksanakan berbagai kebijakan, terutama kebijakan moneter Kesehatan bank dihitung menggunakan analisis rasio NPL (Non Performing Loan), LDR (Loan to Deposit Ratio), ROA (Return On Assets), ROE (Return On Equity), NIM (Net Interest Margin), CAR (Capital Adequency Ratio). Berdasarkan analisis kesehatan bank menunjukkan rasio bahwa rata-rata rasio NPL PT. Bank Mandiri (Persero)Tbk sebesar 1,42%, PT. Bank Tabungan Negara (Persero) Tbk sebesar 3,40%. Rata-rata rasio LDR PT. Bank Mandiri (Persero) Tbk sebesar 69,58%, PT. Bank Tabungan Negara (Persero) Tbk sebesar 96,66%. Rata-rata rasio ROA PT. Bank Mandiri (Persero) Tbk sebesar 3,04%, PT. Bank Tabungan Negara (Persero) Tbk sebesar 1,63%. Rata-rata rasio ROE PT. Bank Mandiri (Persero) Tbk sebesar 17,66%, PT. Bank Tabungan Negara (Persero) Tbk sebesar 12,84%. Rata-rata rasio NIM PT. Bank Mandiri (Persero) Tbk Sebesar 4,53%, PT. Bank Tabungan Negara (Persero) Tbk sebesar 4,43%. Rata-rata rasio CAR PT. Bank Mandiri (Persero) Tbk sebesar 17,35%, PT. Bank Tabungan Negara (Persero) Tbk sebesar 17,43%. dari rata-rata kesehatan bank selama sebelas tahun berturut-turut pada PT.Bank Mandiri (Persero) Tbk mendapat predikat Sangat Sehat dengan rata-rata 96,67% dan PT. Bank Tabungan Negara (Persero) Tbk mendapat predikat sehat dengan rata-rata 86,67%.
PERBANDINGAN LIKUIDITAS, SOLVABILITAS, DAN PROFITABILITAS SEBELUM DAN SETELAH RIGHT ISSUE
Authors: Nurmaalasari Siti , Supramono Supramono , Yudhawati Diah
Published: January 2021

Penelitian ini bertujuan untuk mengetahui perbandingan Likuiditas, Solvabilitas, dan Profitabilitas sebelum dan sesudah melakukan Right Issue. Penelitian ini dilakukan terhadap 2 (dua) perusahaan yang bergerak dibidang subsektor jasa kontruksi yang melakukan Right Issue di Bursa Efek Indonesia selama tahun 2012-2018. Rasio yang digunakan dalam penelitian ini adalah antara lain : Current Ratio (CR), Quick Ratio (QR), Return on Assets (ROA), Return on Equity (ROE), Net Profit Margin (NPM), Debt Equity Ratio (DER), dan Debt to Assets. Dari hasil analisis perbandingan Likuiditas,Solvabilitas, dan Profitabilitas yang diukur dengan Current Ratio (CR), Quick Ratio (QR), Return on Assets (ROA), Return on Equity (ROE), Net Profit Margin (NPM), Debt Equity Ratio (DER), dan Debt to Assets terdapat perbandingan sebelum dan sesudah melakukan Right Issue. Rasio keuangan Likuiditas dan Profitabilitas pada kedua perusahaan tersebut lebih baik sebelum Right Issue dibandingkan setelah Right Issue.Tetapi rasio Solvabilitas perusahaan PT Waskita Karya Tbk dan PT Adhi karya pada Debt to Equity Ratio unsolvable.Namun Debt to assets pada PT Adhi Karya Tbk di tahun 2012-2013 solvable dan di tahun 2014 unsolvable.
PENGARUH KUALITAS JASA DAN KEPERCAYAAN KONSUMEN
Authors: Jaryati Eka , Eldine Achyar , Muniroh Leny
Published: January 2021

Penelitian ini dilakukan dengan tujuan untuk menguji pengaruh Kualitas Jasa Dan Kepercayaan Konsumen terhadap Keputusan menggunakan Jasa JNE Express, baik secara parsial (masing-masing) maupun secara simultan (bersama-sama). Terdapat tiga variabel yang digunakan yaitu: Kualitas Jasa dan Kepercayaan Konsumen sebagai dependent variable, sedangkan Keputusan sebagai independent variable. Alat analisis yang digunakan adalah analisis regresi linier sederhana dan analisis regresi linier berganda. Sampel yang di ambil dengan menggunakan metode Slovin. Hasil penelitian menunjukkan bahwa secara parsial (masing-masing) variabel Kualitas Jasa dan Kepercayaan Kosumen memiliki pengaruh yang terhadap Keputusan. Secara simultan (bersama-sama) variabel Kualitas Jasa dan Kepercayaan Kosumen memiliki pengaruh yang signifikan terhadap Keputusan menggunakan Jasa JNE Express.
Ruotsinsalmen aaveet – 1700-luvun merisodan virtuaalisen mallintamisen ja immersiivisen esittämisen haasteet
Authors: Sahari Aaro
Published: January 2021

Virtuaaliteknologialla voidaan rakentaa museoon kokemus kadonneesta fyysisestä menneisyydestä ja antaa nykyihmisille mahdollisuus aistia kadonnutta historiaa ja kulttuuriperintöä. Teknologia tehostaa historiallisen kulttuuriperinnön ja siitä lähteiden varassa tehtyjen tulkintojen saavutettavuutta. Virtuaali­ historia eroaa kirjallisesta historiasta ja perinteisistä museotuotannoista erityisesti siinä, että virtuaali­ teknologialla toteutettu menneisyyden uudelleentulkinta vaatii tutkijoiden ja virtuaaliteknologian am­ mattilaisten saumatonta yhteistyötä. Merikeskus Vellamossa Kotkassa avautui kesällä 2020 näyttely Kohtalona Ruotsinsalmi, joka avaa Kustaan sodan (1788–1790) kulkua merellä ja seurauksia ranni­ kolla sekä esittää Ruotsinsalmen toisen meritaistelun monimediaisesti. Yksi näistä on peliteknologialla toteutettu Savua aalloilla ­elämys, jossa sodan päättänyt Ruotsinsalmen toinen meritaistelu tuodaan museokävijän nähtäville virtuaalisesti. Elämystä varten tehtiin merkittävä määrä historiantutkimusta, jotta saaristolaivastojen alukset ja miehistöt voitiin rakentaa digitaalisesti uudelleen tulkittuina. Täs­ sä katsauksessa esittelen Ruotsin ja Venäjän Itämerellä 1700­luvun lopussa toimineiden saaristo­ laivastojen alusten digitaalista mallintamista, siihen liittyviä tiedollisia ongelmia ja sitä käsittelevää virtuaalitodellisuushanketta.
Home of Game Research – HeGRiC and Game Studies at the University of Helsinki
Authors: Grufstedt Ylva , Rautalahti Heidi , Lasausse Lysiane
Published: January 2021

Game studies refers to a multidisciplinary field of scholarly studies of games and play which is establishing as an independent academic discipline in Finland. Helsinki Game Research Collective (HeGRiC) is an emerging network for game studies, based at the University of Helsinki. Its purpose is to increase the visibility of game studies and to facilitate collaboration and expertise accumulation within the University. This essay discusses the origin and goals of HeGRiC as a network to support game studies, discusses the development of game research at the University of Helsinki, and finally, outlines the network’s declarations of intent.