bluuebunny/crossref_metadata_2025 huggingface dataset:
Preliminary clinical study of a new method of treatment of corneal burn defects
Authors:   Helmholtz National Medical Research Center of Eye Diseases, Moscow, Bozhenko D.A. , Chentsova E.V. ,   Helmholtz National Medical Research Center of Eye Diseases, Moscow
Published: June 2022

Purpose. Of the work is to compare the effectiveness of treatment of burn ulcers with canned amnion and amnion saturated with lysate of autologous platelet-rich plasma (PRP). Material and methods. To compare the effectiveness of treatment of canned amnion and lysate-soaked PRP, 10 patients with ulcers with an area of more than ½ of the cornea after fresh burns of 2–3 degrees aged from 26 to 53 were observed, divided into 2 equal groups. In the comparison group, the treatment of ulcers was carried out against the background of conservative treatment by covering the cornea with an amniotic membrane for 7 days, after which the amnion was removed and the condition of the cornea was monitored. If necessary, the procedure was repeated. In the experimental group, an amniotic membrane saturated with lysate of autologous PRP was used. The assessment of the condition of the cornea was carried out using clinical and instrumental studies, including visometry, biomicroscopy with fluorescein staining, photoregistration and OCT on the Heidelberg Engineering “OCT Spectralis” apparatus. Results. In patients of the experimental group, transplantation of an amniotic membrane impregnated with PRP lysate, in comparison with conventional amnion, led to epithelization of ulcers faster by an average of 7 days, the cornea remained more transparent, and visual acuity was higher by 0,17. Conclusions. The use of an amniotic membrane saturated with PRP lysate may be a promising method of treating corneal burn ulcers. Keywords: amnion; platelet-rich plasma; platelet lysate; corneal ulcers; corneal burns.
Efektivitas Kebijakan Pemerintah Tentang Pengembangan Kompetensi Kerja Melalui Program Kartu Prakerja Studi Program Kartu Prakerja Dalam Mengatasi Pengangguran Di Kabupaten Tebo Provinsi Jambi
Authors: Rahman Doni , Rahman Khairul
Published: June 2022

The Government's Policy on the Development of Work Competencies through the Pre-Employment Card ProgramThe Pre-Employment Card Program in Overcoming Unemployment in Tebo Regency, Jambi Province is implemented bythe Implementing Management of the Pre-Employment Card Program and assisted by the Tebo Regency Department ofIndustry, Trade and Manpower. This program is structured to develop work competencies, increase productivity andcompetitiveness of the workforce, and develop entrepreneurship, the main objective is to provide training to the workforce so that the workforce can work. Therefore, the training in the program must be in accordance with the needs of the existing labor market. The purpose of this study was to determine the effectiveness of the pre-employment card program in overcoming unemployment in Tebo Regency, as well as to determine the factors that influence the implementation of the pre- employment card program in Tebo Regency. The method used is qualitative using primary and secondary data. The results of the study on the effectiveness of the Government's Policy on the Development of Work Competenciesthrough the Study Pre-Employment Card Program The Pre-Employment Card Program in Overcoming Unemployment in Tebo Regency, Jambi Province is indeed still Less Effectiv because the pre-employment card program has not yetconfirmed employment after participants become alumni of the pre-employment card. However, in terms of the accuracy of program targets, program socialization and program monitoring can be said to be effective.
A Preliminary Study on the Effectiveness of Harpin Protein and Potassium Thiosulphate Foliar Applications on Yield and Quality Characteristics in Second Crop Cotton (Gossypium hirsutum L.)
Authors: CANAVAR Salih , ÜNAY Aydın
Published: June 2022

The foliar applications such as harpin protein and potassium thiosulfate (KTS) play a crucial role in cotton growing under especially adversely soil conditions. This study was conducted to evaluate the different combinations of harpin protein and KTS for yield, yield components and fiber quality in second crop cotton (Gossypium hirsutum L.). The differences among treatments were significant for first picking percentage, seed cotton yield and fiber fineness. The applications of harpin protein at peak squaring and harpin protein at first flowering + after 21 days harpin protein were induced the earliness of cotton. The highest seed cotton yield was recorded in harpin protein at peak squaring with 4231.6 kg ha-1, whereas the fibers became coarser with the harpin protein and KTS applications. Results obtained from the current study indicated the potential effect of harpin protein and KTS on increasing the seed cotton yield.
Batı Anadolu’da Ekstrem Sıcaklıklardaki Zamansal Değişimler
Authors: AKSOY Samet , YEŞİLIRMAK Ercan
Published: June 2022

Bu çalışmada, Batı Anadolu’da 1966–1976, 1977–1997, 1998–2018 ile 1966–2018 yılları arasında ekstrem sıcaklık indislerinin yıllık ve mevsimlik ölçeklerde zamansal değişimlerinin incelenmesi amaçlanmıştır. Batı Anadolu’da yer alan 35 meteoroloji istasyonunda, 1966–2018 yılları arasında kaydedilen günlük maksimum ve minimum sıcaklıklar kullanılmıştır. RClimDex yazılımı kullanılarak on yedi ekstrem sıcaklık indisi üretilmiştir. İndislerin zamansal değişimlerinin istatistiksel önem düzeyi Mann–Kendall testi ile değişimlerin büyüklükleri ise Sen’in Eğim testi ile belirlenmiştir. Çalışma sonucunda, genel olarak, 1966–1976 döneminde soğuk indislerde artış, sıcak indislerde azalma trendi gözlenmiş, sonraki alt dönemlerde ve tüm dönem boyunca, daha kuvvetli olmak üzere, soğuk indislerde azalış, sıcak indislerde ise artış eğilimi bulunmuştur. Yaz mevsimindeki trendler diğer mevsimlerdekinden daha kuvvetlidir. Batı Anadolu’da ekstrem sıcaklık indislerindeki değişimlerin, hem yıllık hem de mevsimsel ölçekte, ortalama sıcaklıklardaki değişimlerle uyumlu olduğu sonucuna ulaşılmıştır.
ACTIVITIES OF BUSINESS STRUCTURES AS AN OBJECT OF MONITORING
Authors:   Lviv University of Business and Law, Skrynkovskyy Ruslan , Kniaz Sviatoslav ,   Lviv Polytechnic National University, Rusyn-Hrynyk Roman ,   Lviv Polytechnic National University, Konovalyuk Iryna ,   Lviv Polytechnic National University
Published: June 2022

The article carried out and theoretically substantiated the importance of using monitoring of the activities of business structures. In conditions of need an increase in costs to ensure an appropriate level of quality of activity, for business structures the need is actualized for development a monitoring system that would allow identifying, analyzing and predicting phenomena and trends, what is critical important in the context of ensuring economic sustainability: sustainability of dynamical equilibrium, sustainability of operation and sustainability of development of the business structure. Meeting this need is quite problematic, since the formation and development of such multifunctional monitoring systems requires the use of special software, which is not only expensive, but must also be adapted to a specific business structure. It is noted that among the components of monitoring systems of business structures distinguish are objects and subjects of monitoring, as well as methods and technologies of monitoring. It was determined that for a more objective and reliable getting a result it is necessary to interview 90 respondents (heads of business structures). Graphically presented are expert assessments regarding the relative importance of information characterizing the activities of business structures. Analyzing the obtained expert data, it was found that the leaders of business structures measure the success of entrepreneurial activity by sales. The static model of activity of the business structure as an object of monitoring is modeled. At the same time, taking into account the relationship between the indicated sets and its components, it is proved that it is possible to expand the continuum of databases of monitoring systems and algorithmize the processes of processing primary information regarding new factor characteristics of the monitoring object.
Making Quantification Relevant Again —the Case of Defeasible EL⊥
Authors: Pensel Maximilian , Turhan Anni-Yasmin
Published: June 2022

Defeasible Description Logics (DDLs) extend Description Logics with defeasible concept inclusions. Reasoning in DDLs often employs rational or relevant closure according to the (propositional) KLM postulates. If in DDLs with quantification a defeasible subsumption relationship holds between concepts, this relationship might also hold if these concepts appear in existential restrictions. Such nested defeasible subsumption relationships were not detected by earlier reasoning algorithms—neither for rational nor relevant closure. In this report, we present a new approach for EL ⊥ that alleviates this problem for relevant closure (the strongest form of preferential reasoning currently investigated) by the use of typicality models that extend classical canonical models by domain elements that individually satisfy any amount of consistent defeasible knowledge. We also show that a certain restriction on the domain of the typicality models in this approach yields inference results that correspond to the (weaker) more commonly known rational closure.
Concept Descriptions with Set Constraints and Cardinality Constraints
Authors: Baader Franz
Published: June 2022

We introduce a new description logic that extends the well-known logic ALCQ by allowing the statement of constraints on role successors that are more general than the qualified number restrictions of ALCQ. To formulate these constraints, we use the quantifier-free fragment of Boolean Algebra with Presburger Arithmetic (QFBAPA), in which one can express Boolean combinations of set constraints and numerical constraints on the cardinalities of sets. Though our new logic is considerably more expressive than ALCQ, we are able to show that the complexity of reasoning in it is the same as in ALCQ, both without and with TBoxes.
Constructing SNOMED CT Concepts via Disunification
Authors: Baader Franz , Borgwardt Stefan , Morawska Barbara
Published: June 2022

Description Logics (DLs) [BCM+07] are prominent modeling formalisms underlying the Web Ontology Language (OWL). The lightweight DL EL in particular is used to formulate many biomedical ontologies. DLs allow to represent subconcept-superconcept relationships between concepts, e.g., diseases, as well as more complex correspondences. Unification in DLs has been proposed as a non-standard reasoning task to detect redundant concepts in ontologies [BN01, BM10b]. Recently, disunification in EL has been investigated and several algorithms were proposed to solve disunification problems [BBM16].
Standard and Non-Standard Inferences in the Description Logic FL₀ Using Tree Automata
Authors: Baader Franz , Gil Oliver Fernández , Pensel Maximilian
Published: June 2022

Although being quite inexpressive, the description logic (DL) FL₀, which provides only conjunction, value restriction and the top concept as concept constructors, has an intractable subsumption problem in the presence of terminologies (TBoxes): subsumption reasoning w.r.t. acyclic FL₀ TBoxes is coNP-complete, and becomes even ExpTime-complete in case general TBoxes are used. In the present paper, we use automata working on infinite trees to solve both standard and non-standard inferences in FL₀ w.r.t. general TBoxes. First, we give an alternative proof of the ExpTime upper bound for subsumption in FL₀ w.r.t. general TBoxes based on the use of looping tree automata. Second, we employ parity tree automata to tackle non-standard inference problems such as computing the least common subsumer and the difference of FL₀ concepts w.r.t. general TBoxes.
Ontology-Mediated Query Answering for Probabilistic Temporal Data with EL Ontologies (Extended Version)
Authors: Koopmann Patrick
Published: June 2022

Especially in the field of stream reasoning, there is an increased interest in reasoning about temporal data in order to detect situations of interest or complex events. Ontologies have been proved a useful way to infer missing information from incomplete data, or simply to allow for a higher order vocabulary to be used in the event descriptions. Motivated by this, ontology-based temporal query answering has been proposed as a means for the recognition of situations and complex events. But often, the data to be processed do not only contain temporal information, but also probabilistic information, for example because of uncertain sensor measurements. While there has been a plethora of research on ontologybased temporal query answering, only little is known so far about querying temporal probabilistic data using ontologies. This work addresses this problem by introducing a temporal query language that extends a well-investigated temporal query language with probability operators, and investigating the complexity of answering queries using this query language together with ontologies formulated in the description logic EL.
Privacy-Preserving Ontology Publishing for EL Instance Stores (Extended Version)
Authors: Baader Franz , Kriegel Francesco , Nuradiansyah Adrian
Published: June 2022

We make a first step towards adapting an existing approach for privacypreserving publishing of linked data to Description Logic (DL) ontologies. We consider the case where both the knowledge about individuals and the privacy policies are expressed using concepts of the DL EL, which corresponds to the setting where the ontology is an EL instance store. We introduce the notions of compliance of a concept with a policy and of safety of a concept for a policy, and show how optimal compliant (safe) generalizations of a given EL concept can be computed. In addition, we investigate the complexity of the optimality problem.
Deductive Module Extraction for Expressive Description Logics (Extended Version)
Authors: Koopmann Patrick , Chen Jieying
Published: June 2022

In deductive module extraction, we determine a small subset of an ontology for a given vocabulary that preserves all logical entailments that can be expressed in that vocabulary. While in the literature stronger module notions have been discussed, we argue that for applications in ontology analysis and ontology reuse, deductive modules, which are decidable and potentially smaller, are often sufficient. We present methods based on uniform interpolation for extracting different variants of deductive modules, satisfying properties such as completeness, minimality and robustness under replacements, the latter being particularly relevant for ontology reuse. An evaluation of our implementation shows that the modules computed by our method are often significantly smaller than those computed by existing methods.
Computing Compliant Anonymisations of Quantified ABoxes w.r.t. EL Policies (Extended Version)
Authors: Baader Franz , Kriegel Francesco , Nuradiansyah Adrian , Peñaloza Rafael
Published: June 2022

We adapt existing approaches for privacy-preserving publishing of linked data to a setting where the data are given as Description Logic (DL) ABoxes with possibly anonymised (formally: existentially quantified) individuals and the privacy policies are expressed using sets of concepts of the DL EL. We provide a chacterization of compliance of such ABoxes w.r.t. EL policies, and show how optimal compliant anonymisations of ABoxes that are noncompliant can be computed. This work extends previous work on privacypreserving ontology publishing, in which a very restricted form of ABoxes, called instance stores, had been considered, but restricts the attention to compliance. The approach developed here can easily be adapted to the problem of computing optimal repairs of quantified ABoxes.
Avant-propos
Authors: Herman Thierry
Published: June 2022

[Ce texte n'a pas de résumé].
mise en scène de la surprise dans les écrits scientifiques de sciences humaines
Authors: Tutin Agnès
Published: June 2022

Feelings and emotions are rare in scientific writing, but the emotion of surprise is curiously quite present in this genre, with recurring expressions like "Against all expectations", "It is astonishing that" or "surprising results". The present lexico-semantic study of different marks of surprise in a corpus of 344 research articles in human sciences reveals that it is rarely spontaneous, it is borrowing stereotypical phraseologies and it produces effects of textual breaching. This feeling of surprise is not really an emotional communication, but rather an intentional strategy. This strategy allows boosting the scientific demonstration of the results, complementing the factual scientific facts when the peculiarity of an object is highlighted, or assessing peers with a kind of mitigated point of view.
Genres discursifs et attentes rhétoriques en Faculté des lettres: de l'acquisition des littératies universitaires à leur évaluation
Authors: Béguelin Victoria , Jeanneret Thérèse
Published: June 2022

At the end of the Bachelor degree, students of a Faculty of Arts in Switzerland must master the diverse academic written discursive genres necessary to produce and to convey knowledge in the language they study. Teachers must provide them with keys to improve their writing skills – in terms of form as well as content – by a meaningful assessment. This paper presents the device set up at the Faculty of Arts of the University of Lausanne allowing both students' acquisition of written academic literacy and teachers' assessment. Mainly based on a set of descriptors that defines academic genres' main features, the device leads students to autonomously apprehend the notion of genre, to have specific goals in terms of academic writing, to practice self-assessment and to improve their skills through the revision and rewriting of their texts.
Quels critères pour déterminer la "meilleure" explication scientifique?
Authors: Wagemans Jean H. M.
Published: June 2022

In justifying their choice of the 'best' scientific explanation from a number of candidate explanations, scientists may employ specific theoretical virtues and other criteria for good scientific theories. This paper is aimed at providing an inventory of such criteria and at analyzing how they function argumentatively by indicating their systematic place within the pattern of argumentation based on abduction.
"tradition de l'innovation"? Réflexion à partir du corrélat innovation/créativité en DDL
Authors: Castellotti Véronique , Debono Marc , Huver Emmanuelle
Published: June 2022

Can we say that innovation has become a "tradition” in Language Didactology and Didactics? Then what hides behind this race for innovation, assuming a constant improvement? We develop here a possible interpretation of this phenomenon through the study of correlated innovation and creativity, starting from its historical and epistemological foundations, which reveals a prevailing "technical” vision of languages and of language appropriation, and which shows more broadly an intention to control human relationships. Finally, we will outline another possible direction where tradition would be a heuristic tool, especially for teacher training, leading to language didactics that deal with appropriation processes, based on the notions of imagination and relationship (vs. creativity, innovation and efficiency).
Degradation Pathways of Cobalt-free LiNiO2 Cathode in Lithium Batteries
Authors: Pan Ruijun , Jo Eunmi , Cui Zehao , Manthiram Arumugam
Published: June 2022

Electrode-electrolyte reactivity (EER) and particle cracking (PC) are considered two main causes of capacity fade in high-nickel layered oxide cathodes in lithium-based batteries. However, whether EER or PC is more critical remains debatable. Herein, the fundamental correlation between EER and PC is systematically investigated with LiNiO2 (LNO), the ultimate cobalt-free lithium layered oxide cathode. Specifically, EER is found more critical than secondary particle cracking (SPC) in determining the cycling stability of LNO; EER leads to primary particle cracking (PPC), but contrary to conventional wisdom, prevents SPC. Two surface degradation pathways are identified for cycled LNO under low and high EERs. A common blocking surface reconstruction layer (SRL) containing electrochemically-inactive Ni3O4 spinel and NiO rock-salt phases is formed on LNO at the charged state in an electrolyte with high EER; in contrast, an electrochemically-active SRL featuring regions of electron- and lithium-ion-conductive LiNi2O4 spinel phase is formed on LNO at the charged state in an electrolyte with low EER, even though bulk LiNi2O4 crystals are believed to be non-existent. These findings unveil the intrinsic degradation pathways of LNO cathode and are foreseen to provide new insights into the development of lithium-based batteries with minimized EER and maximized service life.
Stable D-xylose ditriflate in divergent syntheses of dihydroxy prolines, pyrrolidines, tetrahydrofuran-2-carboxylic acids, and cyclic sugar -amino acids
Authors: Juan Carlos Estevez Cabanas , Balo Rosalino , Fernandez Alberto G. , Chopdat Adam , El Ayadi Soufian , Jiménez Alejandro , Kato Atsushi , Estevez Ramon J. , Fleet George W. J.
Published: June 2022

Double nucleophilic displacement of a sugar D-xylose ditriflate derived from diacetone-D-glucose by amines, water and alkyl cyanoacetates gave a series of bicyclic divergent intermediates for the synthesis of a wide range of highly functionalized targets, including hydroxylated prolines, pyrrolidines, THF carboxylic acids, and cyclopentanes
Characterization of Lipid Bilayers Adsorbed to Functionalized Air/Water Interfaces
Authors: Pusterla Julio Martín , Scoppola Ernesto , Appel Christian , Mukhina Tetiana , Shen Chen , Brezesinski Gerald , Schneck Emanuel
Published: June 2022

Lipid bilayers immobilized in planar geometries, such as solid-supported or "floating" bilayers, have enabled detailed studies of biological membranes with numerous experimental techniques, notably x-ray and neutron reflectometry. However, the presence of a solid support also has disadvantages as it complicates the use of spectroscopic techniques as well as surface rheological measurements that would require surface deformations. Here, in order to overcome these limitations, we investigate lipid bilayers adsorbed to inherently soft and experimentally well accessible air/water interfaces that are functionalized with Langmuir monolayers of amphiphiles. The bilayers are characterized with ellipsometry, X-ray scattering, and X-ray fluorescence. Grazing-incidence X-ray diffraction reveals that lipid bilayers in a chain-ordered state can have significantly different structural features than regular Langmuir monolayers of the same composition. Our results suggest that bilayers at air/water interfaces may be well suited for fundamental studies in the field of membrane biophysics.
Polar organic chemical integrative sampler (POCIS) allows compound specific isotope analysis of substituted chlorobenzenes at trace levels
Authors: Suchana Shamsunnahar , Gavazza Sávia , Melo Natanna , Edwards Elizabeth , Lomheim Line , Mack E. Erin , Passeport Elodie
Published: June 2022

Compound specific isotope analysis (CSIA) is an established tool to demonstrate in situ degradation of traditional groundwater contaminants at heavily contaminated sites, usually at mg/L range aqueous concentrations. Currently, an efficient preconcentration method is lacking to expand CSIA to low aqueous concentration environmental samples. This work demonstrated the compatibility of polar organic chemical integrative sampler (POCIS) with CSIA of C, H, and N isotopes for four NH2- and NO¬2-substituted chlorobenzenes at low μg/L. Diffusion and sorption showed insignificant carbon isotope fractionation (<0.7‰) in laboratory experiment, except for a reproducible shift of 1.6‰ for 3,4-dichloronitrobenzene. A similar constant reproducible shift of 0.8-2‰ was evident for N-CSIA. Whereas, the compatibility of POCIS for H-CSIA seems to be analyte specific possibly reflecting the adsorption mechanism to POCIS by H-bonding. Performance of the POCIS-CSIA method was evaluated in a pilot constructed wetland where comparable C- and N-CSIA results were obtained from grab sampling and POCIS. This work opens the potential of CSIA application to the low concentration polar emerging contaminants in the environment, such as pesticides, pharmaceuticals, and flame-retardants.
ICHOR: A Modern Pipeline for Producing Gaussian Process Regression Models for Atomistic Simulations
Authors: Burn Matthew , Popelier Paul
Published: June 2022

Current practical use of machine learning is more involved than model architecture and the optimisation technique itself. It is very important that the modern machine learning method is supported with a robust set of tools for the creation and manipulation of data sets. ICHOR is one such tool designed for the purpose of creating fast and accurate atomistic Gaussian process regression (GPR) models through the use of active learning. ICHOR operates in the context of FFLUX, a fully polarisable force field based on the energies and multipole moments of quantum topological atoms. ICHOR interacts with the in‐house GPR program FEREBUS for training, and with DL_FFLUX (derived from DL_POLY) for geometry optimisation and molecular simulation. ICHOR utilises the latest technologies in HPC cluster management to produce GPR models reliably at scale.
Mild and scalable synthesis of phosphonorhodamines
Authors: Turnbull Joshua , Golden Ryan , Benlian Brittany , Miller Evan
Published: June 2022

Since its discovery in 1887, rhodamines have become indispensable fluorophores for biological imaging. Recent studies have extensively explored heteroatom substitution at the 10' and a variety of substitution patterns on the 3', 6' nitrogens. Although 3-carboxy-substituted rhodamines were first reported in 1887 and their 3-sulfonated derivatives in 1896, the 3-phosphono analogues have never been reported. We recently reported the synthesis of 3-phosphono fluoresceins, which possessed nearly identical spectral properties to the parent carboxy dyes, but showed enhanced water solubility. However, synthesis and purification were difficult, and yields were low (<17%). Here, we report a mild, generalizable, and scalable synthetic route to 3-phosphonorhodamines. We explore the substrate scope and investigate mechanistic details of the acid-free condensation. Tetramethyl-3-phosphonorhodamine (pTMR) derivatives can be accessed on the 1.5 mmol scale in up to 98% yield (2 steps). Phosphonorhodmines show a 12- to 500-fold increase in water solubility over 3-carboxy and 3-sulfonorhodamine derivatives and have excellent chemical stability. Phosphonates allow for derivatization, and esterification of pTMR allows intracellular delivery with localization profiles that differ from 3-carboxyrhodamines. The free phosphonate can be incorporated into a molecular wire scaffold to create a phosphonated rhodamine voltage reporter, phosphonoRhoVR. PhosRhoVR 1 can be synthesized in just 6 steps, with an overall yield of 37% to provide >400 mg of material, compared to a 6-step, ~2% yield for the previously reported RhoVR 1. PhosRhoVR 1 possesses excellent voltage sensitivity (37% ΔF/F) and a 2-fold increase in cellular brightness compared to RhoVR 1.
Antibodies to the phosphatidylserine/prothrombin complex in the diagnosis of antiphospholipid syndrome
Authors: Reshetnyak Tatiana M. , Cheldieva Fariza A. , Cherkasova Mariya V. , Lila Aleksander M. , Nasonov Evgeny L.
Published: June 2022

Aim. To determine the significance of antibodies to the phosphatidylserine/prothrombin complex (aPS/PT) in patients with systemic lupus erythematosus (SLE) antiphospholipid syndrome (APS).
Materials and methods. A total of 190 patients were included in the study: 123 (64.7%) with reliable SLE and 55 (29%) with PAPS. The control group included 100 relatively healthy subjects of comparable age. All patients were tested for classical aPL as well as IgG/IgM-anti-PS/PT by enzyme immunoassay.
Results. Based on the average values of IgG/IgM aPS/PT of the control group, the levels of positivity were allocated mean (M) + 3 or 5 standard deviations (SD): M+3SD and M+5SD. IgG aPS/PT levels above 73.6 U/ml (M+5SD) were more accurate diagnostic, for IgM aPS/PT above 18.0 U/ml. IgG-aPS/PT were detected in 84 (44%) of 190 patients. Levels above diagnostic levels were detected in 68 (65%) of 104 patients with APS (55 with PAPS and 59 with SLE+APS). Thrombosis was significantly more common in patients with IgG aPS/PT compared with patients negative for IgG aPS/PT. Arterial but not venous thrombosis was associated with IgG aPS/PT positivity.
Conclusion. The frequency of detection of IgG aPS/PT in the examined patients was 44%, IgM aPS/PT 29% and their combination 19% of 190 patients. Half of the patients with probable APS had positive IgG aPS/PT and third IgM aPS/PT. Median IgG aPS/PT were significantly higher in patients with APS compared to patients without APS and the control group. Thrombosis was associated with IgG aPS/PT. Arterial thrombosis was significantly more frequently reported in patients with IgG aPS/PT. The sensitivity of IgG aPS/PT for reliable APS at levels greater than 73.6 units/ml was 59%, specificity 92%, for IgM aPS/PT 35% and 91%, respectively.
Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome
Authors: Muradian Andranik A. , Sychev Dmitry A. , Blagovestnov Dmitry A. , Petrov Demyan I. , Skukin Dmitry S. , Epifanova Irina P. , Sozaeva Zhannet A. , Kachanova Anastasia A. , Denisenko Natalia P. , Abdullaev Sherzod P. , Grishina Elena A.
Published: June 2022

Aim. To evaluate the possible association of CYP2C8 gene polymorphisms with the clinical efficacy and safety of ketorolac in relation to postoperative pain.
Materials and methods. The study included 107 patients after video laparoscopic cholecystectomy, who received ketorolac (30 mg 2.0 w/m 3 r/d) as postoperative pain relief. All patients were genotyped for CYP2C8. The pain syndrome was assessed using the visual analog scale, the McGill pain questionnaire. The profile of adverse reactions was assessed by the dynamics of red blood counts, as a possible trigger for the development of gastrointestinal bleeding according to the method of global assessment of triggers (Global Trigger Tool GTT).
Results. According to visual analog scale data: in carriers of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs11572080) after 12, 24, 36, 48 hours the intensity of pain syndrome is lower than in carriers of the wild type (p0.05). According to the McGill pain questionnaire, there were no statistically significant differences in pain intensity between the two groups.
Conclusion. In carriers of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs11572080), the effectiveness of anesthesia with ketorolac is higher than in carriers of the wild type. Carriage of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs10509681) does not affect the risk of developing adverse reactions after ketorolac anesthesia.
Immuno-inflammatory rheumatic diseases and COVID-19: analysis of clinical outcomes according to the data of the register of patients of the Novosibirsk region receiving therapy with genetically engineered biological drugs
Authors: Korolev Maxim A. , Letyagina Elena A. , Sizikov Alexey E. , Bogoderova Larisa A. , Ubshaeva Yuliya B. , Omelchenko Vitaly O. , Akimova Anna A. , Mullagaliev Arsen A. , Chumasova Oksana A. , Kurochkina Yuliya D.
Published: June 2022

Background. Currently, observations are accumulating indicating the negative effect of therapy with a number of biologic disease-modifying anti-rheumatic drugs (bDMARDs) drugs on the course of COVID-19. These facts determine the relevance of studying the factors of severe course and unfavorable outcome in immuno-inflammatory rheumatic diseases (IIRD) patients treated with bDMARDs in order to develop tactics for managing this category of patients in a pandemic.
Aim. To evaluate the influence of clinical and demographic factors on the risk of development, severity of the course and clinical outcomes of a new coronavirus infection in patients suffering from IIRD and receiving therapy with genetically engineered biological drugs.
Materials and methods. A retrospective analysis of the database of the register of patients with IIRD receiving bDMARDs in the Novosibirsk region was performed, which included 318 patients, 94 of whom had indications of having suffered viral infection/pneumonia for the period from 01.04.2020 to 31.12.2020.
Results. According to the data obtained, at the time of the analysis, 94 people out of 318 patients with IIRD had a new coronavirus infection. Most (53%) of the patients had a mild infection. At the same time, the nosological form, the use of anti-rheumatic drugs and glucocorticoids did not increase the risks of severe coronavirus infection. When using bDMARDs, only anti-B-cell therapy (rituximab) associated with statistically significant increase in the risk of severe/extremely severe COVID-19. The mortality rate according to the analysis of the register was 6,38%.
Conclusion. Patients with IIRD have a high risk of severe coronavirus infection, while the severity of the disease is associated with the type of therapy performed.
The burden of progression of psoriatic arthritis. All-Russian register data
Authors: Korsakova Yulia L. , Loginova Elena Yu. , Korotaeva Tatiana V. , Gubar Elena E. , Glukhova Svetlana I. , Vasilenko Elizaveta A. , Nasonov Evgeny L.
Published: June 2022

Background. Psoriatic arthritis (PsA) is a complex immune-mediated disease in which a third of patients with psoriasis (PsO) have a inflammatory lesion of both the musculoskeletal system (peripheral joints and axial structures) and extra-articular manifestations (dactylitis, enthesitis, nail PsO, uveitis and inflammatory bowel disease).
Aim. To assess the burden of PsA progression in real practice according to the Russian register of PsA patients.
Materials and methods. Seven hundred thirty seven M/F=350 (47.5%)/387 (52.5%) patients with PsA from the Russian register of PsA patients were included. Mean age 47.412.7 yrs., duration of PsO 200.6158.9 mo., PsA 79.681.9 mo. All patients were divided into 2 groups by PsA duration: 1st gr 36 mo 288 (39.1%) and 2nd gr 36 mo 449 (60.9%). All patients underwent standard clinical examination of PsA activity. Tender (68) and swelling (66) joint count (TJC, SJC), DAPSA, LEI, tenderness of the plantar fascia, PsO BSA (%), PASI, HAQ-DI, PsAID-12, BMI (kg/m2), ESR (mm/h), CRP (mg/l) and comorbidities by ICD-10 were evaluated. Parametric and non-parametric methods of statistical analysis were used. All p0.05 were considered to indicate statistical significance.
Results. In patients with PsA duration 36 mo we found significant prevalence of erosions by X-Ray, axial PsA, BMI30 kg/m2, HAQ-DI1, PsAID-124, arterial hypertension, metabolic syndrome and overall comorbidity (p0.05). There were no significant differences between groups in PsO severity by BSA3%, PASI1, LEI1, TJC, SJC, dactylitis, ESR30 mm/h, CRP10 mg/l, DAPSA, diabetes mellitus, hyperlipidemia, coronary heart disease and liver damage (p0.05).
Сonclusion. Long-standing stage PsA is associated with erosions, axial PsA, worst health related quality of life, functional disability and increased cardio-metabolic disorders and overall comorbidity. Our results support the idea to start bDMARDs at early stage of PsA, it can improve better outcomes.
On the specific treatment of asthenic states: focus on sulbutiamine
Authors: Bykov Yuri V. , Bekker Roman A.
Published: June 2022

In this article, we try to present the available data regarding the pharmacokinetics and pharmacodynamics of sulbutiamine (Enerion), the mechanisms of its anti-asthenic action. Then we analyze and summarize the available evidence base considering the efficacy and safety of Enerion for the treatment of asthenic syndromes. Then we compare Enerion with some other drugs. The results of our review indicate the high efficacy and safety of sulbutiamine in the treatment of asthenia. Our results also show that Enerion has some clinically relevant advantages over all alternatives we reviewed there.
Levilimab and baricitinib prescribing experience in outpatient COVID-19 patients’ treatment
Authors: Khripun Alexey I. , Starshinin Andrey V. , Antipova Yulia O. , Lysenko Mariana A. , Urozhaeva Yulia V. , Gavrilenko Olga F. , Rusantsova Natalya A. , Tyazhelnikov Andrei A. , Tikhonovskaya Elena Yu. , Okolot Natalia V. , Sokolova Maria V. , Fomina Daria S. , Simonova Elena N. , Kruglova Tatiana S. , Chernov Anton A. , Zagrebneva Alena I.
Published: June 2022

Aim. To study the effect of levilimab or baricitinib in combination with standard therapy (ST) on the incidence of severe viral pneumonia associated with a new coronavirus infection COVID-19.
Materials and methods. A multicenter, open-label observational study of the efficacy and safety of levilimab in combination with ST (group 1, n=100), baricitinib in combination with ST (group 2, n=139), or in comparison with ST (group 3, n=200) in outpatients with verified CT-1 pneumonia.
Results. According to the results of laboratory tests, patients treated with levilimab in combination with ST had the best dynamics of changes in CRP from reliably the highest level (mg/L) to the lowest in comparison with other groups. In the group of patients with ST, in contrast to the other groups, no dynamics of CRP was observed by day 5 of therapy. In group of hospitalized patients initially receiving levilimab in addition to ST, the rate of transfer to the intensive care unit (2 patients, 9.52%) and length of stay (4 days) was significantly lower compared to the values in patients in both the baricitinib group in combination with ST (7 patients, 15.56%; 5 days [interquartile range 36.5]) and in patients receiving ST alone (7 patients, 15.56%; 5 days [interquartile range 36.5]). Also in hospitalized patients we observed no statistically significant intergroup differences in the incidence of infectious complications and thromboembolic events, which confirms the safety of including levilimab or baricitinib in COVID-19 pathogenetic therapy regimens. Observational results support the hypothesis that the initial inclusion of levilimab or baricitinib in addition to ST is accompanied by a reduced risk of viral pneumonia progression.
Conclusion. The addition of levilimab or baricitinib to the therapy regimen for coronavirus infection during the outpatient phase has demonstrated a preemptive anti-inflammatory effect and reduced the probability of lung tissue damage progression.
Effect of Optiglaze Coating on the Staphylococcus aurous and Porosity of Heat Cured Acrylic Material
Authors: Rashid Amal A
Published: June 2022

Background: Polishing technique for acrylic resin material have great effect on properties of acrylic material and bacterial colonization such as staphylococcus aurous, which are responsible for many acrylic prosthetic infections such as the commonly ocular infections. Ineffective polishing technique could affect roughness and subsequently porosity of acrylic materials.So, a new effective method for polishing acrylic was used depending on the use of optiglaze coating material. So, this study aimed to evaluate the effect of optiglaze polishing on porosity of acrylic resin material and staphylococcus aurous activity in comparison to conventional polishing technique. 

Materials and methods: Specimen(n=120) were prepared :20 specimens constructed as circle shaped diameter 30mm with 1 mm thickness for porosity  test (10 control polishing by conventional technique and 10 polishing by optiglaze technique). Other 82 specimens were prepared as circle specimen (6mm diameter and 1mm thickness) for sensitivity and adherences test ( each test have 20 specimens10 control and 10 optiglaze) and 42 specimens for viability test for three dilution,21 specimens for control and 21 for optiglaze (7 specimens for each dilution). Porosity were tested by light microscopic while agar well technique, adherence test and viability count test were tested for antibacterial activity of optiglaze against staphylococcus aurous.

Result: The high mean value for porosity test was recorded by control while low mean value was recorded by optiglaze group with significant differences between them. Sensitivity and adherence test high mean value recorded by optiglaze with highly significant differences in comparison to control. Viability count test all dilution 10-7 ,10-6, 10-5 showed highly significant reduction in viability count of staphylococcus aurous by optiglaze group in comparison to control. Conclusion Polishing technique by Optiglaze significantly decrease porosity of acrylic resin and this method inhibited growth of staphylococcus aurous, and decrease its viable count (have antibacterial effect) but had less effect in adherence of this bacterial in comparison to control.
TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy
Authors: Zhang Li , Dietsche Felicia , Seitaj Bruno , Rojas-Charry Liliana , Latchman Nadina , Tomar Dhanendra , Wüst Rob CI , Nickel Alexander , Frauenknecht Katrin BM , Schoser Benedikt , Schumann Sven , Schmeisser Michael J , vom Berg Johannes , Buch Thorsten , Finger Stefanie , Wenzel Philip , Maack Christoph , Elrod John W , Parys Jan B , Bultynck Geert , Methner Axel
Published: June 2022

Ion fluxes across the inner mitochondrial membrane control mitochondrial volume, energy production, and apoptosis. TMBIM5, a highly conserved protein with homology to putative pH-dependent ion channels, is involved in the maintenance of mitochondrial cristae architecture, ATP production, and apoptosis. Here, we demonstrate that overexpressed TMBIM5 can mediate mitochondrial calcium uptake. Under steady-state conditions, loss of TMBIM5 results in increased potassium and reduced proton levels in the mitochondrial matrix caused by attenuated exchange of these ions. To identify the in vivo consequences of TMBIM5 dysfunction, we generated mice carrying a mutation in the channel pore. These mutant mice display increased embryonic or perinatal lethality and a skeletal myopathy which strongly correlates with tissue-specific disruption of cristae architecture, early opening of the mitochondrial permeability transition pore, reduced calcium uptake capability, and mitochondrial swelling. Our results demonstrate that TMBIM5 is an essential and important part of the mitochondrial ion transport system machinery with particular importance for embryonic development and muscle function.
Urban Methane Emissions in Auckland, New Zealand
Authors:   , O'Sullivan-Moffat Harrison
Published: June 2022

Using a mobile survey sampling technique, my research investigates the spatial distribution of urban methane emissions in Auckland, New Zealand. The mobile survey technique uses a car equipped with a high precision methane measurement instrument. This is the first time this technique has been implemented in New Zealand. Methane is the second most important greenhouse gas. Methane emissions from urban areas make up about 10% of NZ’s methane emissions and are poorly constrained. Urban methane emissions are understood to come from landfills, wastewater treatment plants, and fugitive natural gas. Results of this research can help improve existing greenhouse gas inventories. The first component of this research, a city-wide survey, yielded many results. Wastewater treatment plant emissions were observed in detail, showing substantial emissions, with the most emissions around the H2S scrubber and odour bed components of the wastewater plant. Landfills showed variable emission rates, several landfills with methane capture technology appear to have substantial emissions to the atmosphere. Closed landfills were identified as an emission source that appeared to be excluded from current inventory estimates. We found methane emissions present near two thirds of natural gas infrastructure sampled, indicating natural gas is a significant methane source for Auckland. This has advanced the understanding of urban methane emissions in Auckland.

The second focus of this research is “behind-the-meter emissions”. These are emissions from private dwellings and household gas appliances either leaking or emitting un- combusted natural gas. This research has observed evidence of behind the meter emissions happening at an appliance level consistent with previous international research. Then, an experiment was performed to observe temporal variations of emission profiles at a suburb level. The number of “spikes” indicative of methane leaks were observed at least three times more frequently during the early evening than other parts of the day, suggesting the temporal variation was caused by the on/off cycle of natural gas appliances which are used more in the evening. This source could be a significant contribution to urban methane emissions in Auckland. This is the first-time temporal variations in behind the meter emissions have been observed, advancing the wider field of urban greenhouse gas emission research.
O PAPEL DAS OFICINAS DIDÁTICAS NA FORMAÇÃO DO PROFESSOR DE GEOGRAFIA
Authors: Sousa Sara Raquel Cardoso Teixeira de , Medeiros Thais Costa , Santos Francisco José Da Silva
Published: June 2022

O presente artigo tem como objetivo principal compreender a importância das oficinas didáticas ofertadas no curso de Licenciatura em Geografia do CESC/UEMA. E como objetivos específicos: verificar a estrutura curricular do curso de Geografia do CESC/ UEMA; apresentar as principais características das oficinas didático-pedagógicas na formação inicial e analisar o impacto das oficinas didáticas ofertadas aos discentes durante a formação acadêmica. Foram analisadas oficinas ofertadas em três semestres (2018 e 2019), aplicadas dentro da disciplina de Prática da Dimensão Educacional (135h). Após o desenvolvimento das oficinas, os discentes passaram por uma avaliação de desempenho e por entrevista semi-estruturada. As oficinas foram desenvolvidas com a finalidade de trabalhar conteúdos específicos pouco explorados da matriz curricular como: ensino inclusivo; metodologias não convencionais no ensino da Geografia, dentre outras temáticas. Notou-se que as oficinas pedagógicas permitiram aos discentes desenvolver habilidades didáticas significativas, além de ter oportunizado contato com leituras diversificadas de Geografia que abordam as temáticas das oficinas ministradas. Percebeu-se também que os discentes demonstraram melhor desenvoltura durante as interferências didáticas em sala de aula no Ensino Básico, refletindo em suas ações no momento da disciplina de prática, de estágio e no exercício profissional.
Perspectivas epistemológicas en el locus de las ciencias cognitivas
Authors: Vanegas Garcia José Hoover , Gamboa Suárez Audin Aloiso , Gómez Arévalo José
Published: June 2022

La idea etimológica de conocimiento nos da las pistas para comprender el concepto que tanto se ha trabajado desde la filosofía y, en la actualidad en la psicología y aún en la epistemología. De este modo, el presente texto muestra un amplio estudio documental que aborda el campo epistemológico con una mirada desde las ciencias cognitivas con un objetivo claro: tematizar los estudios de la ciencia en sus relaciones con la cognición y sus implicaciones en la evolución epistemológica.