bluuebunny/crossref_metadata_2025 huggingface dataset:
Humanistic Values in Metaphoric Expressions of Traditional Marriage in Tolaki Mekongga Kolaka
Authors: Takwa  , Arafah Burhanuddin , Sopiandy Dede , Taqfiah Suci Jum’atul , Arafah Azhariah Nur B.
Published: August 2022

This paper discusses the humanistic values based on the local wisdom of Mekongga dialect of Tolaki. It focuses on the form of metaphorical expressions. The problem relates to the types of humanistic values contained in the text "mowindahako" (expression relates to customary marriages accomplishment). The metaphorical expression in the marriage custom is not only an unusual form of speech in society, but it is also an indication of various local policies of the people who use it. Tolaki Mekongga community in Kolaka Regency, Southeast Sulawesi, has a very strong cultural background. The data source of this research is the text expression of "mowindahako". The data were obtained by conducting interviews and observations at the time a wedding ceremony was performed and also the published texts as a comparison. The results of data analysis indicate that the humanistic values in the text of "mowindahako" are packaged in an understandable metaphorical form based on the cultural context of the community, family values, respect for fellow human beings, and praying for mutual safety. The expressions of these values are in form of human metaphors of human, substance, living of flora and plants, the energy of water, and being (truth). In addition, in the expression of traditional marriage, the wisdom of the community in solving various problems, the wisdom of the supporting community in obeying the provisions or rules that have been mutually agreed upon, and the wisdom of the community in maintaining the harmony of life and association, especially the internal life of the supporting community.
Efectos Problemáticos de la Neoliberalización de las Universidades Públicas en Colombia
Authors: Castelao-Huerta Isaura
Published: August 2022

Desde 1992, en Colombia se han implementado políticas neoliberales en la educación superior pública. El objetivo de este artículo es exponer cuáles son los efectos problemáticos que ha traído la aplicación de dichas políticas, a partir de una revisión de la literatura publicada entre 1991 y 2019. Tras realizar una búsqueda a partir de palabras clave en diversas bases de datos, se llevó a cabo un análisis hermenéutico de 45 trabajos y, posteriormente, se establecieron las tendencias emergentes. Los resultados señalan que tanto la Ley 30 de 1992 como los decretos en materia salarial y la escasez de fondos para investigación tienen efectos problemáticos para las universidades públicas colombianas. Entre ellos, se destaca que las universidades deben auto-gestionarse una parte de sus recursos; que el desfinanciamiento a las instituciones incrementa los déficits presupuestarios; y, que la implementación del sistema salarial que incentiva económicamente la productividad académica no ha estado acompañado de una contrapartida de recursos estatales para aumentar los presupuestos de las universidades ni los fondos para investigación.
Calcitonin testing in patients with thyroid nodules for screening medullary thyroid carcinoma: a “gray zone”
Authors: Severskaya N. V. , Ilyin A. A. , Chebotareva I. V. , Zhelonkina N. V. , Isaev P. A. , Polkin V. V. , Ivanov S. A. , Kaprin A. D.
Published: August 2022

Introduction. The results of the calcitonin (Ctn) study in patients with thyroid nodules are included in the clinical guidelines for the treatment of differentiated thyroid cancer. However, the management of patients with moderately elevated Ctn up to 100 pg/mL is not clearly defined.

Materials and methods. The study included 103 patients with thyroid nodules and a Ctn level above the reference, but not more than 100 pg/ml. The Ctn concentration was determined using the Cobas e platform (Roche, Germany) or by the immunoradiometric method (Izotop, Hungary). 45 patients were operated on. The analysis of the incidence of medullary thyroid carcinoma (MTC), other thyroid and nonthyroid pathology in patients with elevated Ctn scan was carried out. The results of additional examination are presented: the serum cancer embryonic antigen, Ctn in wash-out, stimulated Ctn, gene RET mutation testing.

The study objective is to evaluate the probability MTC with Ctn level <100 pg/ml, propose management tactics for patients with elevated Ctn and negative cytological results.

Results. The incidence of MTC was 22 % (23/103). The maximum probability of mTC was at Ctn above 50 pg/mL (81 %, 13/16), at Ctn 31-50 pg/mL mTC was detected in 38 % (3/8). With Ctn <30 pg/mL and <20 pg/mL, the incidence of MTC was 9 % (7/79) and 6 % (4/64), respectively. In the majority of MTC patients (65 %), the tumor size did not exceed 1 cm. However, 22 % (5/23) had metastases to the neck lymph nodes. postoperative Ctn normalization was achieved in 96 % (22/23). In 26 % (5/19), a RET germ-line mutation was detected, most often p.val804met.

Among patients without MTC, other thyroid tumors were found in 35 % (28/80), more often papillary thyroid cancer (25 %, 20/80). 13 % (10/80) had other malignant neoplasms. parathyroid adenoma was detected in 3 % (2/80). The maximum Ctn in this group was in patients with chronic kidney disease and metastatic liver disease with cholestasis and ascites.

Cancer embryonic antigen was increased in 53 % of patients with MTC and in 7 % of patients without MTC. Ctn in washout was >2000 pg/mL in mTC and up to 938 pg/mL in patients with histologically confirmed absence of MTC.

Conclusion. If the Ctn level is <100 pg/mL and there is no cytological confirmation, the issue of surgery is decided individually, taking into account many factors. After excluding other causes of hypercalcitoninemia (hyperparathyroidism, kidney disease, other tumors), measurement of serum cancer embryonic antigen and Ctn in wash-out is recommended. In some cases, testing for a RET mutation can be helpful.
Postnatal neurogenesis in the human brain
Authors: Mustafin Rustam N. , Khusnutdinova Elza K.
Published: August 2022

Recently, a lot of data has been gathered which demonstrates neurogenesis in the brain of adult humans. In genetics, findings have been obtained that not only prove, but also elucidate the molecular mechanisms of neurogenesis. In some publications, however, morphology disputes neuronal renewal in adulthood. Therefore, this review presents the modern achievements of epigenetics, morphology, and physiology, which confirm and characterize postnatal neurogenesis in detail. We suggest that the introduction of molecular genetic technologies into morphological studies will be the starting point for the integration of these areas, complementing each other for the introduction of targeted therapy in clinical practice. Numerous evidence has been obtained of the presence of postnatal neurogenesis in adult humans in studies using bromodeoxyuridine, a carbon isotope of 14C, and 3H-thymidine, in comparative analyses of experimental data from animals. Neuronal stem cells, represented by radial glia present in the subventricular and subgranular zones of the human brain, are morphologically similar to neuroepithelial cells. They express marker proteins for astrocytes, which suggests that the proliferation of neuroglia found in adults can also indicate the regeneration of neurons. To prove this, further studies are required, with the exact identification of newly-formed cells, using specific molecular markers, and data from modern epigenetics. The integration of molecular genetic methods into morphology will facilitate not only the accurate determination of the classification of cells to a specific subpopulation but also to study the effects of various agents on the proliferation of neurons in the adult brain.
Comparative analysis of morphological changes in renal tissue under the influence of light desynchronosis
Authors: Zlobina Olga V. , Ivanov Alexey N. , Milashevskaya Taisiya V. , Seryogina Valeria Yu. , Bugaeva Irina O.
Published: August 2022

AIM: To compare morphological changes that occur in renal tissue, as a result of exposure to various models of light desynchronosis.
MATERIAL AND METHODS: This study was conducted on 48 white rats. Three experimental groups were exposed to light for 21 days. The LL (0:24) model was studied in the first group, while the LD 18:6 and 12:10 models were studied in the second and third groups, respectively. The control group was kept in natural conditions all through the experiment.
The animals were placed under anesthesia with a combination of Telazol (ZoetisInc, USA) and Xylanit (Nita-farm, Russia). Afterward, their right kidney was removed. The samples obtained were prepared according to the standard method. Statistical processing was performed using the package of applied statistical programs "STATISTICA 10" (StatSoft , USA).
RESULTS: Morphological disorders of the renal tissue were observed in the three experimental groups. In the first experimental group, there was a significant segmentation of the glomeruli, accompanied by dystrophic changes in the renal tubules. In the second experimental group, glomerular segmentation was more pronounced. In the renal tissue of animals of the third experimental group, the disorders were highly observable, and the sclerotized segment is noted. Changes in morphometric indicators were significant across all experimental groups.
CONCLUSION: Desynchronosis harms the renal tissue by causing changes in its morphology. The most significant disorders characterized by sclerosis were observed in the kidneys of animals in the third experimental group.
O Mio Bambino Caro
Authors:   , Palmer Matthew G. , Yau Pamela , Vakharia Neville
Published: August 2022

This paper reviews today's opera audiences and analyzes marketing practices by major opera companies in the United States in order to target audiences below the age of forty years old. The purpose of this paper is to determine methods that have proven to be successful, as well as those that have proven to be unsuccessful, for opera companies to gain a more diverse age demographic in their audiences and build more sustainable audiences for the future. Interviews were conducted with employees from three of the United States' major opera companies: Lyric Opera of Chicago, Houston Grand Opera, and San Francisco Opera. These interviews provided insight into how each organization works to improve their audience demographics and sustain continuous patronage of younger individuals.
Ölüme Götüren Ağaç: Porsuk Meyvesi
Authors: Özesen Toygün Anıl , Kaya Kenan , Malkoç Mehmet Ali , Gülmen Mete Korkut
Published: August 2022

Yew fruit can cause a large number of human and animal poisoning and can be highly toxic. This is achieved by the taxon alkaloids (Taxin A and Taxin B) that cause cardiotoxic effects in its structure. Taxins cause cardiac dysrhythmia with the effect of calcium channel antagonism in cardiac myocytes and cause a clinical deterioration leading to death. The diagnosis of yew fruit poisoning is usually made by identifying plant parts in the digestive system. With the recent technological developments and the development of toxicological diagnosis methods, the diagnosis of metabolites in lower doses has begun to be made more easily with clinical suspicion.
Cinsel İçerikli Mesajlaşmanın Öteki Yüzü: Bakış Açısı ve Mağduriyet Arasındaki İlişki
Authors: Ergül Dila , Ziyalar Neylan
Published: August 2022

Amaç: Cinsel içerikli mesajlaşma, internet ve sosyal medyanın yaygın kullanımıyla mesaj, fotoğraf ve video gönderiminin hızlı ve kolay hale gelmesi sonucu ortaya çıkmış ve günümüzde sık karşılaşılan bir kavram haline gelmiştir. Çalışmada cinsel içerikli mesajlaşmanın araştırma örneklemi kapsamındaki yaygınlığını, cinsel içerikli mesajlaşmaya bakış açısını etkileyen faktörleri ve mağduriyet ile cinsel içerikli mesajlaşma arasındaki ilişkiyi incelemek amaçlanmıştır.
Gereç ve Yöntem: 18 yaş ve üzeri 565 katılımcı araştırmanın örneklemini oluşturmuştur. Cinsel içerikli mesajlaşmaya bakış açısı ve eylemde bulunma durumu Gerekçeli Eylem Kuramı referans alınarak saptanmıştır. Veriler araştırmacılar tarafından hazırlanan demografik bilgi formu ve cinsel içerikli mesajlaşma ölçeği ile toplanmıştır.
Bulgular: Katılımcıların %70.4’ü (398) kadın, %29.6’sı (167) ise erkeklerden oluşmaktadır. Yaş dağılımına göre katılımcıların %61.4’ü (347) 18-25, %38.6’sı (218) 26 ve üzeri yaş grubunda yer almaktadır ve yaş ortalaması 25.2’dir. Katılımcıların oldukça büyük bir çoğunluğunun cinsel içerikli mesajlaşma eyleminde bulunduğu, erkeklerin kadınlara kıyasla daha olumlu tutuma sahip olduğu ve daha sık eylemde bulunduğu, mağduriyet yaşamış olmanın cinsel içerikli mesajlaşmaya bakış açısı üzerinde anlamlı bir farklılık yaratmadığı belirlenmiştir. Öte yandan cinsel içerikli mesajlaşmadan dolayı mağduriyet yaşayan bireylerin oranı %22.5 olmakla beraber mağduriyet yaşayan bireylerin çoğunluğunun kadın olduğu saptanmıştır. Mağduriyet şekilleri incelendiğinde bireylerin en çok duygusal ve psikolojik problemler yaşadığı; fakat mağduriyetin tek bir şekille sınırlı kalmadığı belirlenmiştir.
Sonuç: Cinsel içerikli mesajlaşmanın yaygınlığı, bireylerin bakış açıları ve eylemde bulunmaya yönelik motivasyonları belirli ölçülerde tespit edilerek çok fazla göz önünde bulundurulmayan cinsel içerikli mesajlaşmanın Türkiye’deki konumu ve dikkate alınmaya değer olumsuzluklara da sebebiyet verebildiği ortaya konmuştur.
Göz Kliniğinde Uygulanan Aydınlatılmış Onam Formları Yeterli mi?
Authors: Can Hümeyra Yıldırım , Yiğit Yücel , Yüzbaşıoğlu Erdal
Published: August 2022

Objective: In this study, it was aimed to evaluate the informed consent forms obtained before the surgical procedures performed in the eye clinic.
Materials and Methods: Informed consent forms of 300 patients who underwent surgery in the ophthalmology clinic, type of surgery, whether the signature on the consent belongs to the patient, if the signature belongs to someone else, the reason, whether all pages were approved or not, the presence of the patient's handwritten consent, the signature in terms of who was taken, were retrospectively evaluated.
Results: When the consent forms of 300 patients who underwent different surgical procedures were examined, 281 of the signatures belonged to the patients and 19 belonged to someone else. When it was evaluated whether all the pages were signed or not, it was seen that no consent form was signed in accordance with this, and only one page with the patient's name and signature was signed. The forms were signed by the secretary before the operation on the day of surgery.
Conclusion: In our study, informed consent forms were found to be insufficient in many aspects. In order for the physician to protect himself/herself against the risk of a possible medical malpractice claim and to protect the rights of his/her patients, it is important to inform and obtain consent in accordance with ethical and medical procedures.
SOSYAL MEDYA PAZARLAMA FAALİYETLERİNİN YEME-İÇME İŞLETMELERİ MÜŞTERİLERİNİN İLHAMI VE MARKA BAĞLILIĞI ÜZERİNDEKİ ETKİSİ: KARADENİZ TEKNİK ÜNİVERSİTESİ ÖĞRENCİLERİ ÜZERİNDE BİR ÇALIŞMA
Authors: RAHIMI Ziauddin , KIRKBİR Fazıl
Published: August 2022

Sosyal medya, yeni bir pazarlama platformu olarak hem marka bağlılığına zemin hazırlama hem de müşterilere ilham vermeye sebep olmada önemli bir kaynaktır. Bu çalışmanın amacı, yeme-içme işletmelerinin sosyal medya platformlarında gerçekleştirdikleri pazarlama faaliyetlerinin, müşteri ilhamı ve bağlılığını nasıl etkilemeye sebep olduğunu ölçmeyi amaçlamaktadır. Çalışma, 15-30 Nisan 2022 tarihlerinde Karadeniz Teknik Üniversitesin 'de (n=388) öğrenciyle kolayda örnekleme yöntemi kullanılarak (yüz yüze ve çevrimiçi anket formu) (Google Forms) yapılmıştır. İlk olarak araştırmada kullanılan ölçeğin geçerliliği ve güvenirliği SPSS ve AMOS programları kullanarak kanıtlanmıştır. Ardından araştırma hipotezlerini test etmek için YEM kullanılmıştır. Doğrulayıcı faktör analiz sonucunda sosyal medya pazarlama faaliyetlerinin bilgilendirme ve eğlence olmak üzere iki boyuttan oluştuğu belirlenmiştir. Yeme-İçme İşletmelerinin sosyal medya platformlarında gerçekleştirdikleri pazarlama faaliyetlerinin bilgilendirme boyutu hem marka bağlılığı hem de müşteri ilhamı üzerinde pozitif ve anlamlı bir etkiye sebep olduğunu belirlenmiştir. Yeme-İçme İşletmelerinin sosyal medya platformlarında gerçekleştirdikleri pazarlama faaliyetlerinin eğlence boyutu marka bağlılığı üzerinde pozitif ve anlamlı bir etkiye sebep olduğu belirlenmiştir. Ama müşteri ilhamı üzerinde anlamlı etkisi olmadığı ortaya çıkmıştır.
DENETİM RAPOR TÜRLERİNİN FİRMA DEĞERİ ÜZERİNDEKİ ETKİLERİNİN ANALİZİ
Authors: ECE Oğuzhan , ÇADIRCI Bülent Diclehan
Published: August 2022

Çalışma, Türkiye ölçeğinde firmalar ile firma çıkar grupları arasındaki güvencenin temellerinden biri olan denetim raporlarının, firma piyasa değeri üzerindeki etkilerini tespit edip ampirik kanıtlar sunmayı amaçlamaktadır. Bu çerçevede 2010/Q1-2021/Q3 dönemi için BİST 100’de yer alan ve finansal olmayan 77 firma özelinde olumlu, olumsuz ve görüş bildirmekten kaçınma şeklindeki denetim görüşleri panel veri metodolojisi çerçevesinde Driscoll-Kraay Tahmin yöntemiyle incelenmiştir. Analiz sonucunda firma piyasa değerini olumlu denetim görüşünün pozitif, görüş bildirmekten kaçınma şeklindeki denetim görüşünün ise negatif etkilediği sonucuna ulaşılmıştır. Diğer yandan olumsuz denetim raporları ile firma değeri arasında anlamlı bir ilişkiye rastlanılmamıştır. Çalışma neticesinde ulaşılan sonuçların denetim görüşü ve firma değer ilişkisi özelindeki sınırlı literatüre katkı sağlamasının yanında yatırım sürecinde yatırımcılar için bir perspektif oluşturabileceği de beklenmektedir.
DİJİTAL HASTANE ORTAMINDA ÇALIŞAN SAĞLIK PROFESYONELLERİNİN DENEYİMLERİ; AVANTAJLAR, KOLAYLIKLAR VE GÜÇLÜKLER
Authors: ALKAN DEMİR Asuman , TORUN Nazan
Published: August 2022

Bu çalışma sağlık sektöründe Dijital Hastane uygulamalarının Türkiye‘deki yeri ve önemini belirlemek, dijital hastane özelliği taşıyan bir sağlık kurumunda dijitalleşme yolunda yaşanan avantajları, kolaylıkları ve güçlükleri ortaya koymak amacıyla yapılmıştır. Çalışmada nitel araştırma yöntemlerinden fenomenolojik desen kullanılmıştır. Araştırmanın çalışma grubu, amaçsal örneklem yöntemiyle Ankara Gazi Mustafa Kemal Devlet Hastanesinde çalışan personel olarak belirlenmiştir. Veriler yüz yüze yarı-yapılandırılmış görüşmeler neticesinde toplanmıştır. Niteliksel verilerin analizinde ise içerik analiz yöntemi kullanılmıştır. Yapılan görüşmelerde katılımcıların dijital hastane sisteminin teknoloji ve bilgi çağı olan günümüzde uygulanmasının kaçınılmaz olarak bulmuşlardır. Ayrıca katılımcılar dijital hastane sisteminin avantaj ve kolaylıkların olduğu kadar uygulanmasında bir takım güçlüklerinde olduğunu ifade etmişlerdir. Bu bağlamda görüşmeler sonucunda beş ana, altı alt tema oluşturulmuştur. Dijital Hastane Uygulamalarının Türkiye‘de gelişmesi için öncelikle mevcut durumun ortaya konulması ile bunların kullanımına ilişkin stratejiler hazırlanması, hem Sağlık Bakanlığının ilgili yetkililerin hem bu hizmeti sunan personelin hem de HBYS firmalarının bu konuda eğitilmesi ve devletin bu konuda teşvikleri ile denetimlerin sağlaması önemlidir.
Kandungan Hukum Islam Dalam Ayat-Ayat Mutasyabihat
Authors: Ruslan Ruslan
Published: August 2022

Abstract: The study of mutasyabihat verses in relation to Islamic law looks rather unusual. This is because the assumption built by the scholars is "the mutasyabihat verses concentrate more on the field of aqidah (al-ahkam al-I'tiqadiyah)". Meanwhile, the verses regarding halal-haram law include the muhkamat verse (the meaning is clear); as opposed to the mutasyabihat verse. This paper attempts to present the content of Islamic law (shara' law) in mutasyabihat verses. The result actually strengthens the existence of mutasyabihat verses on musykil, musytarak, and mubham pronunciations. The themes of the verse become clearer when viewed with a substantive approach, for example the law of marriage polygamy, the tradition of destroying the back wall of the house after Umrah or Hajj, the law against polytheists, the meaning of quru' for women who have lost their husbands, the law on coalitions of Muslims and non-Muslims. , and others tend to say that the legal verses are actually more mutasyabihat. The aim is allegedly to strengthen faith in Allah and so that the universality of the Qur'an is maintained Abstrak: Kajian tentang ayat-ayat mutasyabihat dalam hubungannya dengan hukum Islam terlihat agak tidak lazim. Hal ini karena asumsi yang dibangun para ulama   “ayat-ayat mutasyabihat lebih berkonsentrasi pada bidang akidah (al-ahkam al-I’tiqadiyah)”. Sementara ayat-ayat tentang hukum halal – haram termasuk ayat muhkamat (jelas maknanya); sebagai lawan ayat mutasyabihat. Tulisan ini berusaha mengemukakan  kandungan hukum Islam (hukum syara’) dalam ayat-ayat mutasyabihat. Hasilnya justuru menguatkan adanya ayat-ayat mutasyabihat  pada lafal-lafal musykil, musytarak, dan mubham. Tema-tema ayat pun menjadi lebih jelas ketika dilihat dengan pendekatan substantif misalnya hukum poligami perkawinan, tradisi merusak tembok belakang rumah  setelah  umrah atau  haji, hukum memerangi orang musyrik,  makna quru’ bagi wanita yang ditinggal mati suami, hukum koalisi muslim dan non-muslim,  dan  lain- lain cenderung dikatakan ayat-ayat hukum justru lebih banyak mutasyabihatnya. Tujuannya diduga untuk mengokohkan keimanan kepada Allah dan agar universalitas Alquran  tetap terpelihara
DESAKRALISASI OTORITAS KEAGAMAAN TUAN GURU PURIFIKASI SALAFI VERSUS TRADISIONALISME NAHDLATUL WATHAN
Authors: Saparudin Saparudin
Published: August 2022

This study aims to analyze the traditional Islamic practice of Nahdlatul Wathan (NW) in positioning and attaching the religious authority of Tuan Guru or Kyai, which is being challenged by the Salafi purification movement. This also determines the efforts needed to desacralize this authority by the Salafi elite who united by the perception that the sacredness of certain people, including Tuan Guru, is unknown in Islam, and even contradicts Islamic teachings with claims based on the salaf manhaj. Data collected was based on the phenomena from the ideological contestation at the elite level of the two religious groups that affect the pattern of religion and the internal interaction of religious people in Lombok. It was then analyzed using the contestation theory framework operationally formulated by Antje Winner. Based on empirical tendencies, the result showed that the desacralization of religious authority is not solely influenced by theological factors of religious understanding rather by the struggle for the religious authority of religious elites in the public sphere. This indicates the increase in the number of Salafi preachers who carry the purification theme in various mosques and Majlis Taklim, the higher the probability of seeing educational institutions as a new challenge for Tuan Guru to maintain religious authority. The implication is that there is social fragmentation and conflict involving sectarian sentiments of religious groups, where the contestation of religious elites contributes.
Garden square as landscape-architectural territory of recreational and functional purpose in city of Ussuriisk, Primorsky Krai
Authors:   Primorsky State Agricultural Academy, Kolyada A.S. , Belov A.N. ,   Far Eastern Federal University (FEFU), Rozlomy N.G. ,   Primorsky State Agricultural Academy, Berseneva S.A. ,   Primorsky State Agricultural Academy
Published: August 2022

The study results of ten garden squares in the city of Ussuriysk (Primorsky Krai) are discussed in the paper. Their functional purpose, composition of woody plants, architectural features are analyzed. A significant part of the garden squares (50 %) is intended for family recreation, others are used for pedestrians and short-term recreation. The plantings contain both native and introduced plants. The Square named after the 40th anniversary of the Victory has the largest area (3,9 hectares), the smallest one is the Square named after the 150th anniversary of Ussuriysk and the square on Chicherin Street, 77 (0,2 hectares each). Rectangular garden squares predominate. Measures are proposed for the landscape transformation of the studied green areas such as the expansion of the floristic composition, redevelopment in order to use such areas for family recreation with children of different ages.
Intensive regimens of chemotherapy with hematopoetic stem cell rescue in paediatric patients with high-risk malignant tumors
Authors: Dinikina Y. V. , Morgacheva D. A. , Smirnova A. Y. , Toshina Yu. K. , Lapaeva S. I. , Egorov A. S. , Tereshina A. A. , Belogurova M. B.
Published: August 2022

Background. One of the possible options to intensify therapy in patients with high-risk malignant tumors is high-dose chemotherapy (HDCT) with autologous hematopoetic stem cell rescue. However, this method has a high risk of acute and delayed toxicity, and, sometimes doesn’t meet the expected effectiveness. This confirms the necessity of more considerate approach for choosing the category of patients for this therapeutic option with the determination of the most significant factors on the part of the patient and the type of malignant tumor.

Objective. Analysis of the results of HDCT with autologous hematopoetic stem cell transplantation (HSCT) in children with high-risk solid malignancies, conducted in the Department of pediatric oncohematology and BMT of the Federal State Budgetary Institution “V.A. Almazov National Medical Research Center”.

Design and methods. We perform a retrospective analysis of 55 cycles of HDCT with autologous hematopoetic stem cell rescue provided from 2017 to 2020 in 39 patients with high-risk malignant tumors. The toxicity and efficacy of the method were assessed taking into account the frequency of infectious complications, early post-transplant mortality, event-free (EFS) and overall survival (OS).

Results. The predominant category of patients were children with CNS tumors (61.5 %). Mean age of the patients was 2 years 9 months. At the time of HDCT 35.9% of patients were in complete remission (CR), 64.1 % had signs of active disease (AD). In 59% of patients, one course of HDCT was performed, in 41 % — tandem transplantation was performed according to the recommendations of the protocol for the treatment of the disease. The most common conditioning regimen was carboplatin + etoposide (27.3 %). The predominant source of hematopoietic stem cells were peripheral stem cells (87.3 %). The frequency of infectious complications in the post-transplant period was 100 %, neutropenic enterocolitis (61.8 %) and febrile neutropenia (34.5 %) were predominant. A high frequency of reactivation of CMV infection (25.4 %) was noted, meanwhile CMV disease occurred in 35.7 % of cases. The most important prognostic factor was the disease status at the time of HDCT. 2-year OS incidence of 85.7 % vs 65.3% and EFS 85.7 % vs 39 % in patients with CR and AD respectively. After completing the course of HDCT with autologous HSCT 94.8 % of patients continued anticancer therapy.

Conclusion. HDCT with autologous HSCT demonstrates a satisfactory toxicity profile and can improve OS and EFS in children with high-risk malignant tumors. A reliable prognostic factor that determines the effectiveness of the method is the disease status at the time of HDCT.
Zebrafish as a model organism for rare diseases of nervous system
Authors: Derzhavina K. A. , Ilyin N. P. , Seredinskaya M. V. , Nerush M. O. , Zakharchenko K. V. , Sorokin D. V. , Demin K. A. , Kalueff A. V.
Published: August 2022

Rare (orphan) diseases are an urgent unmet biomedical problem. Tremendous efforts and resources are expended for the search for cures for these diseases. Zebrafish can provide a powerful screening tool for novel orphan drugs, and may also deepen our mechanistic understanding of such rare pathological conditions. Here, we discuss various models of orphan diseases of the nervous system on zebrafish, and outline associated problems, limitations and prospects in the context of the development of personalized medicine.
Challenges for Western Balkan Countries Regional Integration: the Case of North Macedonia
Authors: Toshevska-Trpchevska Katerina , Disoska Elena Makrevska , Kikerkova Irena , Tonovska Jasna
Published: August 2022

This paper aims to elaborate on the possibilities that increased regional integration initiatives can have in boosting mutual trade among the countries in the Western Balkans region, such as: creating a Regional Economic Area by 2023; the creation of a Common Regional Market based on EU rules in the period 2021-2024 and the initiative “Open Balkan” created between North Macedonia, Serbia, and Albania for enabling free movement of goods and free movement of workers.  For our research, the gravity model of trade for North Macedonia covering the period 2005-2020 is applied. The influence of bilateral and regional trade agreements on the country’s trade is analyzed. The results have shown that for North Macedonia, CEFTA-2006 membership has higher significance for increasing trade when compared to the agreement signed with the EU and to the other bilateral free trade agreements signed with EFTA, Turkey, and Ukraine. This paper point out that deepening trade integration through different regional initiatives could have a positive influence on increasing mutual trade.
Addressing gender-based violence in Peru: Citizenship and critical issues. The Women's Emergency Center (CEM) technicians’ point of view
Authors: Del Pino Espejo Maria José , Sánchez-Tovar Ligia , Soto Arango Diana Elvira , Villalba Karina
Published: August 2022

Objective: To understand critical issues faced by the technical staff working in the Women's Emergency Centers (CEM) in Peru, when assisting women victims of gender violence. 
Originality/support: Valuable information is provided on the assistance provided to women victims of gender-based violence in the MECs. This information is very useful for decision making, aimed at improving the work and effectiveness of the performance of the technicians in the centers. It highlights a situation that has been little studied and serves as a reference for other realities in the international Latin American context.
Method: A qualitative research approach was used to inform the proposed aims. Forty-one technicians from the Women's Emergency Centers (CEM) in Peru participated in the study. The results revealed that the critical issues perceived by the technical staff were working with material and travel limitations, work overload that made it difficult to care for victims, delays in the treatment of cases of gender-based violence and revictimization of the victim. In addition, dealing with a macho cultural framework that masks the situations and with religious and linguistic diversity.
Conclusions: It is concluded that it is necessary to view gender violence with a focus on citizenship and gender justice that under the principles of equality, respect for human rights and defense of cultural diversity, without incurring in a paternalistic action.
Contemporary Art on Realistic Subjects in the New Era of Lacquer Painting
Authors: Ye Zhihao , Jiao Xinyun
Published: August 2022

By using lacquer painting creation with realistic themes as an example, this essay will examine the primary issues with lacquer painting creation with realistic themes in the context of the modern period.It will summarize the key pathways and construction expansion choices for lacquer painting creation with realistic themes by analyzing the creative issues and traits of lacquer painting with realistic themes, and it will provide the future path perspective that may be supported.Modern lacquer paintings with realistic topics suffer from a loss of pictoriality, a weakening of pictoriality, and a lack of aesthetic merit. Lack of creative integrity and originality; little aesthetic effect; lack of a modern viewpoint or historical significance. It is clear that there is a “tendency to profit,” and commercialization results in repetition and homogenization. A few representative lacquer paintings and artworks have been examined by the author.By emphasizing the incorporation of styles from other forms of painting and increasing the lacquer painting’s creative expressive language, the author offers answers.The development of lacquer paintings with realistic subjects in the context of the new period is suggested as well as workable solutions.
Strategi Pembentukan Karakter Islami Siswa Sekolah Dasar di Masa Transisi Covid-19 Menuju Aktivitas New Normal
Authors: BK Muh Khaerul Ummah , Hamna Hamna
Published: August 2022

This study aims to determine the strategy of Islamic religious education teachers in shaping the Islamic personality of students in elementary schools. This study used a qualitative descriptive method involving Islamic religious education teachers, head master and representatives of students' parents as research informants. The results showed that the Islamic religious learning strategy oriented to the formation of the Islamic character of students was carried out adaptively in accordance with local government policies related to learning strategies during the pandemic and the need for the presence of role models to shape students' Islamic personalities. Various solutions that can be applied by Islamic religious education teachers in an effort to form students' Islamic character during pandemic are to apply learning activity scheduling strategies, apply student learning discipline strategies and strengthen exemplary and optimize learning assistance from students' parents.
Pengaruh Kebiasaan Menulis Menggunakan Kata Baku di Media Sosial Terhadap Keterampilan Menulis Mahasiswa di Perguruan Tinggi
Authors: Umam Nanang
Published: August 2022

The purpose of this study in general is to determine the effect of the use of social media on students' writing skills. This study uses a qualitative and quantitative approach, a quasi-experimental type of research (quasi-experimental) with a non-equivalent control group design pattern. The data collection technique used in this research is a test with a test sheet instrument in written or essay form. The results showed that there was a significant difference between writing habits (using standard words) on social media and the writing skills of PGSD students at Muhammadiyah University of Gresik. This is because the degrees of freedom (df) are 25 with tcount > ttable, namely 5.251 > 2.342, so Ho is rejected and Ha is accepted.
A 50-years flood frequency in Coastal area of Java, Indonesia: Integrating historical hotspot and Spatial Autocorrelation Analysis
Authors: Sejati Anang Wahyu , Buchori Imam , Lakshita Nattaya Mlatti , Wiratmaja I.G. Andika , Ulfiana Desyta
Published: August 2022

This paper re-examines the facts of the influence of urban development that developed in Java on the occurrence of floods that started from 1970 to 2020. The purpose of this paper is to prove whether development policies in Indonesia in the last 50 years and to analyze the correlation between flood event, population growth, and urbanization on a wider regional scale. The Moran-I Spatial Autocorrelation Analysis method is applied to simulate the spatial pattern of flood events with combined results from satellite image interpretation with Spatial-temporal analysis from the 1970s to the 2020s. In more detail, the results of hotspot clusters show development from "lower-low" dispersion in the 70s to areas with a majority of "higher-high" clustered in 2000-2020. It proves that the burden of development in Java is in high category impact, so solutions for population distribution, land development, and spatial planning are needed to ensure environmental sustainability in Java.
A Cross Sectional Study On Molecular Prevalence Of Virulent Genes Of Calves Diarrheagenic Escherichia Coli And Bacterial Resistance Profile To Antimicrobials In Selected Towns Of South Wollo Administrative Zone, Amhara, Ethiopia
Authors: Abegaz Fentaw Hussen , Tesema Tesfaye Sisay , Genet Solomon
Published: August 2022

Background: Escherichia coli is a known normal flora of the gastrointestinal tract frequently used as model for various research trials. Potential gain and loss of virulent genes enable it to become pathogenic and causes calf diarrhea while beneficial ones subsidize vitamin K2. These virulent genes are found on plasmids, genomes or integrated on bacteriophages and horizontal gene transfer plays in its epidemiology. This study was conducted to identify virulence genes informative to four pathogenic strains of E. coli and study their antibiotic resistance patterns to eleven antimicrobials.Results: 100 (81.3%) pure isolates of E. coli were harvested, of which, 23 (29.9%) isolates carried one or more of the tested virulent genes. stx1 (18.2%), stx2 (9.1%), eae (11.7%), hlyA (1.3%) were the detected virulent genes with their respective frequency. However, no isolates were detected for bfpA and aatA genes. Virulent genes were detected in 2-4 weeks aged calves at significantly higher order (P ≤ 0.05). Calves housed with their dam and those given supplement feed were significantly associated with detected genes (P ≤ 0.05). From samples processed using PCR, 14 (18.2%) were confirmed as STEC strain, 5 (6.5%) of EHEC and 4 (5.2%) of EPEC. Most isolates were resistant to sulfonamide, clindamycine, ampicillin, Oxytetracyclne, trimethoprime and streptomycin and sensitive to nitrfurantoin, gentamycin, neomycin, clorampfenicol and ciprofloxacine. Conclusion: Zoonotic STEC and EHEC strains are collectively found highest and implies reservoir of calves to both farm animals and humans. Poor farm hygiene and frequent use of limited antibiotics was a problem observed. As a consequence, farms hygiene as well as spatial and temporal distribution of E. coli should be concerned. Additionally, Antibiotics should alternatively be used to avoid resistance.
Construction and Empirical Testing of Comprehensive Risk Evaluation Methods from a Multi-dimensional Risk Matrix Perspective: Taking Specific Types of Natural Disasters Risk in China as an Example
Authors: Li Jimei , Wang Yunhui , Chen An , Wang Guanghui , Yao Xiaohui , Wang Tongtong
Published: August 2022

Global climate change, continuous economic development and accelerated urbanization have increased the frequency and complexity of various incidents. Risk assessment is an important means to deal with different crises and incidents. Based on the systematic analysis of the basic connotation, attribute relationship and main contents of risk assessment, this study extends the traditional two-dimensional risk matrix to multi-dimensional risk matrix. On this basis, this study further proposes four comprehensive risk assessment methods, including total ordinal, weighted average, Euclidean distance and two-norm methods. Empirical research was conducted by selecting three types of natural disasters, regional agro-meteorological disasters, geological disasters and forest fires, in 30 related regions in China between 2010 and 2019. The results indicated that compared to the two-dimensional risk matrix, the multi-dimensional risk matrix can intuitively characterise and compare the all-round risk situation of different regions, periods, types and dimensions, which is more helpful for a systematic analysis and risk comparison. All four evaluation methods proposed in this paper proved able to effectively conduct comprehensive regional risk evaluations with consistent results. However, when considering the fitting coefficient between the results obtained by various evaluation methods and the comprehensive evaluation results, it can be found that the accuracy (i.e. fitting coefficient) of Euclidean distance method is significantly higher than that of the other three methods. In the last 10 years, the temporal order of natural disaster risk in China has been more volatile, with Beijing, Shanxi, Tianjin, Hebei, Liaoning, Ningxia, Zhejiang, Shaanxi, Fujian and Gansu experiencing higher volatility in the ranking of natural disaster risk.
Particle Swarm Optimization (PSO) algorithm for Ground-based Lightning Locating System (GLLS) in Johor, Malaysia: Hazard mitigation implications
Authors: Mehranzamir Kamyar , POUR AMIN BEIRANVAND ,   Zulkurnain Abdul-Malek3 Abdul-Malek3, Afrouzi Hadi Nabipour , Lee Duehee , Rahimi Negar , Alizadeh Seyed Morteza , Alizadeh Mohsen , Pradhan Biswajeet
Published: August 2022

The cloud to ground (CG) lightning has negative impacts on humans and properties. A lightning strike is a great concern to mankind and industry because of its detrimental impact on human safety, hazard, and equipment failures. There are different lightning detection methods, including time difference of arrival (TDOA) and magnetic direction finding (MDF). Using combined techniques is an innovative approach to achieve higher location accuracy and detection efficiency of lightning flashes. In this investigation, a Lightning locating system (LLS) was designed and implemented at University Technology Malaysia (UTM), Johor, Malaysia to detect the cloud to ground lightning discharges in a study area of 400 km2. A particle swarm optimization (PSO) algorithm was applied in this study as the combination mediator to find the optimum point of the lightning strike. The PSO was initialized by 30 particles based on the results of the MDF and TDOA methods. The performance of the PSO-based algorithm is known to be affected by the arrangement of the searching process. The results of the detected lightning strikes by the PSO-based LLS were validated using an industrial lightning detection system for December and March. In addition, the whole study area was divided into 36 equal sections to analyze the abundance of CG discharges in each section. From the experimental data, the mean distance differences between the PSO-based LLS and the industrial LLS inside the study area varied from 0 to 573 m. Therefore, the proposed PSO-based LLS is efficient and accurate to detect and map the lightning discharges occurring within the coverage area. Although an industrial LLS monitors a large area or a country with several sensors, the detected lightning discharges and the statistical data analysis of the captured flashes are not obtainable by public individuals. Meanwhile, estimation and localization of lightning strikes are necessary for the public to mitigate the problems related to lightning discharges. Moreover, this study will be significant for the researchers, the insurance companies, and public users to be aware of the detected storms and estimation of imminent rainfalls. The PSO-based LLS provides an accurate lightning detection system for a specific local region and can be implemented to regional scale in other parts of the world.
Approximation of Discrete and Orbital Koopman Operators over Subsets and Manifolds
Authors: Kurdila Andrew J. , Paruchuri Sai Tej , Powell Nathan , Guo Jia , Bobade Parag , Estes Boone , Wang Haoran
Published: August 2022

This paper describes a general approach for the construction of approximations of the Koopman operator associated with deterministic continuous semiflows over a complete metric space [[EQUATION]] . A primary contribution of the paper is the derivation of rates of convergence for approximations of Koopman operators for large classes of evolution equations. The rates of convergence in the paper are derived in two substantially different scenarios. If the state space [[EQUATION]] is compact, we consider when the samples [[EQUATION]] are dense in the entire state space [[EQUATION]] . We also study cases when samples are dense in a limiting subset [[EQUATION]] that is a proper subset of [[EQUATION]] . Two general classes of methods are described in the paper, referred to as intrinsic and extrinsic methods. Intrinsic methods define bases of approximation from kernels that are defined in terms of, or having knowledge of, the limiting set [[EQUATION]] . Extrinsic methods use kernels that do not depend on the knowledge of the limiting set [[EQUATION]] . In both types of approximations, the regularity of the underlying set and the smoothness of the space of functions on which the Koopman operator acts determine the rate of approximation. In the strongest error bounds derived in the paper, it is shown that the error in approximation of the Koopman operator decays like [[EQUATION]] where [[EQUATION]] is the fill rate of the samples [[EQUATION]] in the limiting set [[EQUATION]] and [[EQUATION]] is an exponent related to the choice of the kernel and the smoothness of functions on which the Koopman operator acts. Such error bounds are obtained when either the limiting subset [[EQUATION]] , when it is a proper subset [[EQUATION]] that is sufficiently regular, or when it is a type of smooth manifold [[EQUATION]] .
Insights about levels and source appointment of petroleum hydrocarbons in Brazilian semi-arid coastal: Baseline status assessment for ocean decade targets
Authors: Oliveira Andre Henrique , Fernandes Gabrielle Melo , Santos Felipe Rodrigues dos , de Almeida Narelle Maia , Nogueira Tiago Rocha , Melo Diego de Quadros , Martins Laercio Lopes , Cavalcante Rivelino Martins , Nascimento Ronaldo Ferreira do , Reddy Christopher Michael
Published: August 2022

The Ocean decade (2021–2030) for sustainable development proclaimed in 2017 by the UN, seeks to promote and conserve the sustainable use of oceans, seas, and marine resources. For this, the distribution of n-alkanes, polycyclic aromatic hydrocarbons (PAHs), and biomarkers, in sediments from the Fortaleza coastal zone​ (Mucuripe harbor (MH) e Inner shelf (ICS)) were used to assess the impacts of anthropogenic activities in the area. The concentrations of total n-alkanes (Σ16 n-alkanes) in MH and ICS sediments varied from 35.9 to 94.9 and 17.9 to 197.3 µg g− 1, respectively, while the isoprenoids phytane and pristane in MH and ICS sediments ranged from 0.1 to 1.69 ug g− 1 and from 0.14 and 1.20 µg g− 1, respectively. Most of the sediment samples presented carbon preference index (CPI) values close to unity, indicating that the area is submitted to petroleum-related sources. The concentrations of Σ16 PHAs in MH and ICS sediments varied from 87.0 to 562.0 and 98 to 288.0 ng g− 1. This work presents the first investigation of the petroleum biomarkers hopanes and steranes in the Fortaleza coastal zone, in which ΣBiomarkers varied from 0.10 to 1.79 and 0.02 to 0.24 ug g− 1 in MH and ICS sediments, respectively. The presence at stations of biomarkers also indicates petrogenic input. The diagnosis of the distribution of pollutants in the investigated zones of the Fortaleza coast suggests contamination from urban areas and oil spills and vessel traffic.
Surf zone-related drownings and injuries based on lifeguard records in Goa beaches (2008-2020)
Authors: Venkateswarlu Ch , V Arun Kumar Surisetty V , Somani Ankit , Gireesh B. , Naidu C V
Published: August 2022

The study is based on lifeguard data from 44 Goa beaches over a period of 2008–2020. Calangute reported the highest Surf Zone Injury (SZI) cases with 24.63% followed by Baga and Candolim in the north Goa. In South Goa, Colva recorded the highest percentage of beach victims with 18.25%. Since, Goa beaches are world-famous, many tourists from foreign countries have become victims with a total percentage of 22.2%, thereby showing its importance to the global community. Out of all Indian states, Karnataka recorded nearly 21.93% cases as compared to Goa with 13.53%. Since, there is a stringent lifeguard system available at Goa beaches, the drowning percentage is just 2.86%. Rips are found to be the primary cause responsible for most cases accounting for 59.32% with nearly 3030 victims. The secondary cause is due to shore breaking. The most common injury type is a fracture of the legs which accounts for 8.02%. Apart from rip current related cases, there are other cases reported due to tourism activities. Out of all recreational activities, wading resulted in more number of SZIs with 19.61% followed by surfing and body boarding. The SZI-related cases have also been examined based on age and gender. The predominant age group involved in the injuries was between 19–25 years (36.33%) with the majority of victims being males (78.59%). These details give an idea of which regions along the beaches, management has to focus on and restrict the zones from any kind of recreational activities. This analysis is the first of its kind in India, where a detailed study is carried on based on lifeguard reports, suggesting the importance of rescue or drowning data.