bluuebunny/crossref_metadata_2025 huggingface dataset:
An Analytical Approach of Integrating Automated Load Scheduling to a Smart Energy Meter using Differential Evolution Algorithm
Authors: Vikram Aditya , Karna Dhairya , Kumar Astitva , Rizwan Mohammad
Published: October 2020

Leading-edge power systems which are employed in present-day scenario are significantly complex, extensively distributed and populous. Rising costs of generating power, ever-increasing demand for electricity and shortage of resources have led to introduction of applications of optimal power systems. Hence Smart Energy Meters (SEMs) and highly efficient algorithms are required to facilitate Automated Load Scheduling (ALS). The latest optimization methods for ALS which works on the principle of genetics and natural selection has been presented in the paper. Differential Evolution (DE) is a simple numerical optimization approach that is easy to implement and significantly faster and robust. This article presents a novel mathematical modelling approach for the minimization of the energy consumption. The paper proposes an in depth modelling approach for ALS considering numerous aspects of the DE: initialization, mutation, crossover and selection. Case-studies have been made which include multiple aspects of non-linearities like prohibited zones of operation and transmission losses. The performance of DE based ALS algorithm was implemented using Python and evaluated at the test site in New Delhi which integrates a local renewable energy source (Local PV Grid) with an SEM. The Peak-to-Average (PAR) Ratio was used as a measure of evaluation. The proposed algorithm saved up to 19.42% power in the best-case scenario.
Molecular Complexity of Working Fluids Dedicated to Organic Rankine Cycle (ORC)
Authors: Matuszewska Dominika
Published: October 2020

Organic Rankine Cycle (ORC) power plants are the most well-known and mature technology used to converting low and medium-temperature heat into electricity, especially from waste heat and renewable energy sources (including geothermal and solar thermal). Despite the level of development of ORC systems available on the market, there are still many aspects in the context of improving those units – constructing economically profitable low power unit, improving efficiency, selection an appropriate working fluid, etc. This paper analyzes 17 workings fluids dedicated to ORC system and discusses an existence of low stability region in their dense vapors and its influence on some peculiarities in behaviors of selected isentropic and dry fluids. The analysis shows relation between the retrograde phenomena in the flow of ORC fluids and mechanical and thermodynamic stability parameters.
Suspensions of deformable particles in Poiseuille flows at finite inertia
Authors: Filippo Chiara Luigi , Edoardo Rosti Marco , Picano Francesco , Brandt Luca
Published: October 2020

We analyze a suspension of deformable particles in a pressure-driven flow. The suspension is composed of neutrally buoyant initially spherical particles and a Newtonian carrier fluid, and the flow is solved by means of direct numerical simulations, using a fully Eulerian method based on a one-continuum formulation. The solid phase is modeled with an incompressible viscous hyperelastic constitutive relation, and the flow is characterized by three main dimensionless parameters, namely the solid volume fraction, the Reynolds and capillary numbers. The dependency of the effective viscosity on these three quantities is investigated to study the inertial effects on a suspension of deformable particles. It can be observed that the suspension has a shear-thinning behavior, and the reduction in effective viscosity for high shear rates is emphasized in denser configurations. The separate analysis of the Reynolds and capillary numbers reveal that the effective viscosity depends more on the capillary than on the Reynolds number. In addition, our simulations exhibit a consistent tendency for deformable particles to move toward the center of the channel, where the shear rate is low. This phenomenon is particularly marked for very dilute suspensions, where a whole region near the wall is empty of particles. Furthermore, when the volume fraction is increased this near-wall region is gradually occupied, because of higher mutual particle interactions. Deformability also plays an important role in the process. Indeed, at high capillary numbers, particles are more sensitive to shear rate variations and can modify their shape more easily to accommodate a greater number of particles in the central region of the channel. Finally, the total stress budgets show that the relative particle-induced stress contribution increases with the volume fraction and Reynolds number, and decreases with the particle deformability.
Beyond Langmuir: surface-bound macromolecule condensates
Authors: Mitchison T. J.
Published: October 2020

Macromolecule condensates, phase separation, and membraneless compartments have become an important area of cell biology research where new biophysical concepts are emerging. This article discusses the possibility that condensates assemble on multivalent surfaces such as DNA, microtubules, or lipid bilayers by multilayer adsorption. Langmuir isotherm theory conceptualized saturable surface binding and deeply influenced physical biochemistry. Brunauer-Emmett-Teller (BET) theory extended Langmuir’s ideas to multilayer adsorption. A BET-inspired biochemical model predicts that surface-binding proteins with a tendency to self-associate will form multilayered condensates on binding surfaces. These “bound condensates” are expected to assemble well below the saturation concentration for liquid–liquid phase separation, so they can compete subunits away from phase-separated droplets and are thermodynamically pinned to the binding surface. Tau binding to microtubules is an interesting test case. The nonsaturable binding isotherm is reminiscent of BET predictions, but assembly of Tau-rich domains at low concentrations requires a different model. Surface-bound condensates may find multiple biological uses, particularly in situations where it is important that condensate assembly is spatially constrained, such as gene regulation.
Highlights and Perspectives From a Collaborative Global Health Pathology Experience in Trinidad and Tobago
Authors: Viswanathan Kartik , Johncilla Melanie
Published: October 2020

Objectives

Global health education is important during residency training in exposing doctors to conditions that are not common in the United States and developing their awareness of global health care disparities. Most medical decisions are based on results from anatomic or clinical pathology laboratories, which are essential services for appropriate medical care in international settings. Nevertheless, US pathology residency trainees have limited global health exposure and thus are rarely exposed to diagnostic services in these settings. Moreover, literature documenting what is needed to create a global health elective in pathology is limited.

Methods

We designed an international pathology elective in Trinidad and Tobago involving one main public hospital site and several off-site laboratories. Objectives and goals were established before the rotation. Apart from daily mentor-led education sessions, the trainee participated in teaching, quality improvement projects, and cultural experiences. Engagement with medical officers, personnel staff, and people in the community was encouraged.Results: Challenges encountered included funding, transportation, limited laboratory resources, medical registration, and malpractice insurance. These were mitigated through carefully planned steps, including communicating with registration bodies and liaising with pathology organizations for funding.

Conclusions

Overall, the global health rotation was successful. We provide a detailed roadmap for other pathology training programs interested in establishing similar global health electives.
Common Childhood Viruses and Pubertal Timing: The LEGACY Girls Study
Authors: McDonald Jasmine A , Cherubin Sinaida , Goldberg Mandy , Wei Ying , Chung Wendy K , Schwartz Lisa A , Knight Julia A , Schooling C Mary , Santella Regina M , Bradbury Angela R , Buys Saundra S , Andrulis Irene L , John Esther M , Daly Mary B , Terry Mary Beth
Published: October 2020

Earlier pubertal development is only partially explained by childhood body mass index; the role of other factors, such as childhood infections, is less understood. Using data from the LEGACY Girls Study (North America, 2011–2016), we prospectively examined the associations between childhood viral infections (cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV) 1, HSV2) and pubertal timing. We measured exposures based on seropositivity in premenarcheal girls (n = 490). Breast and pubic hair development were classified based on mother-reported Tanner Stage (TS) (TS2+ compared with TS1), adjusting for age, body mass index, and sociodemographic factors. The average age at first blood draw was 9.8 years (standard deviation, 1.9 years). The prevalences were 31% CMV+, 37% EBV+, 14% HSV1+, 0.4% HSV2+, and 16% for both CMV+/EBV+ coinfection. CMV+ infection without coinfection was associated with developing breasts an average of 7 months earlier (hazard ratio (HR) = 2.12, 95% confidence interval (CI): 1.32, 3.40). CMV infection without coinfection and HSV1 and/or HSV2 infection were associated with developing pubic hair 9 months later (HR = 0.41, 95% CI: 0.24, 0.71, and HR = 0.42, 95% CI: 0.22, 0.81, respectively). Infection was not associated with menarche. If replicated in larger cohorts with blood collection prior to any breast development, this study supports the hypothesis that childhood infections might play a role in altering pubertal timing.
Automated Noninvasive Central Blood Pressure Measurements by Oscillometric Radial Pulse Wave Analysis: Results of the MEASURE-cBP Validation Studies
Authors: Trinkmann Frederik , Benck Urs , Halder Julian , Semmelweis Alexandra , Saur Joachim , Borggrefe Martin , Akin Ibrahim , Kaden Jens J
Published: October 2020

Background

Central blood pressure becomes increasingly accepted as an important diagnostic and therapeutic parameter. Accuracy of widespread applanation tonometry can be affected by calibration and operator training. To overcome this, we aimed to evaluate novel VascAssist 2 using automated oscillometric radial pulse wave analysis and a refined multi-compartment model of the arterial tree.

Methods

Two hundred and twenty-five patients were prospectively enrolled. Invasive aortic root measurements served as reference in MEASURE-cBP 1 (n = 106) whereas applanation tonometry (SphygmoCor) was used in MEASURE-cBP 2 (n = 119).

Results

In MEASURE-cBP 1, we found a mean overestimation for systolic values of 4 ± 12 mmHg (3 ± 10%) and 6 ± 10 mmHg (9 ± 14%) for diastolic values. Diabetes mellitus and low blood pressure were associated with larger variation. In MEASURE-cBP 2, mean overestimation of systolic values was 4 ± 4 mmHg (4 ± 4%) and 1 ± 4 mmHg (1 ± 7%) of diastolic values. Arrhythmia was significantly more frequent in invalid measurements (61 vs. 18%, P < 0.0001) which were most often due to a low quality index of SphygmoCor.

Conclusions

Central blood pressure estimates using VascAssist 2 can be considered at least as accurate as available techniques, even including diabetic patients. In direct comparison, automated measurement considerably facilitates application not requiring operator training and can be reliably applied even in patients with arrhythmias.
Induction of Cross-Reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-Cell Responses by a Recombinant Matrix-M–Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine
Authors: Shinde Vivek , Cai Rongman , Plested Joyce , Cho Iksung , Fiske Jamie , Pham Xuan , Zhu Mingzhu , Cloney-Clark Shane , Wang Nan , Zhou Haixia , Zhou Bin , Patel Nita , Massare Michael J , Fix Amy , Spindler Michelle , Thomas David Nigel , Smith Gale , Fries Louis , Glenn Gregory M
Published: October 2020

Background

Recurrent reports of suboptimal influenza vaccine effectiveness have renewed calls to develop improved, broadly cross-protective influenza vaccines. Here, we evaluated the safety and immunogenicity of a novel, saponin (Matrix-M)–adjuvanted, recombinant hemagglutinin (HA) quadrivalent nanoparticle influenza vaccine (qNIV).

Methods

We conducted a randomized, observer-blind, comparator-controlled (trivalent high-dose inactivated influenza vaccine [IIV3-HD] or quadrivalent recombinant influenza vaccine [RIV4]), safety and immunogenicity trial of qNIV (5 doses/formulations) in healthy adults ≥65 years. Vaccine immunogenicity was measured by hemagglutination-inhibition assays using reagents that express wild-type hemagglutination inhibition (wt-HAI) sequences and cell-mediated immune responses.

Results

A total of 1375 participants were randomized, immunized, and followed for safety and immunogenicity. Matrix-M–adjuvanted qNIV induced superior wt-HAI antibody responses against 5 of 6 homologous or drifted strains compared with unadjuvanted qNIV. Adjuvanted qNIV induced post-vaccination wt-HAI antibody responses at day 28 that were statistically higher than IIV3-HD against a panel of homologous or drifted A/H3N2 strains, similar to IIV3-HD against homologous A/H1N1 and B (Victoria) strains and similar to RIV4 against all homologous and drifted strains evaluated. The qNIV formulation with 75 µg Matrix-M adjuvant induced substantially higher post-vaccination geometric mean fold increases of influenza HA-specific polyfunctional CD4+ T cells compared with IIV3-HD or RIV4. Overall, similar frequencies of solicited and unsolicited adverse events were reported in all treatment groups.

Conclusions

qNIV with 75 µg Matrix-M adjuvant was well tolerated and induced robust antibody and cellular responses, notably against both homologous and drifted A/H3N2 viruses. Further investigation in a pivotal phase 3 trial is underway.

Clinical Trials Registration

NCT03658629.
Effects of sodium zirconium cyclosilicate on sodium and potassium excretion in healthy adults: a Phase 1 study
Authors: Någård Mats , Singh Bhupinder , Boulton David W
Published: October 2020

Background

Sodium zirconium cyclosilicate (SZC; formerly ZS-9) is a potassium (K+) binder for treatment of hyperkalemia in adults. SZC binds K+ in exchange for sodium (Na+) or hydrogen (H+) in the gastrointestinal tract, conveying potential for systemic absorption of Na+.

Methods

This single-center Phase 1 study evaluated the effects of SZC on Na+ and K+ excretion in healthy, normokalemic adults. During an initial run-in period (Days 1–2), participants started a high K+/low Na+ diet. After baseline (Days 3–4), SCZ 5 or 10 g once daily (QD) was administered (Days 5–8). The primary endpoint was mean change in urinary Na+ excretion from baseline (Days 3–4) to the treatment period (Days 7–8).

Results

Of 32 enrolled participants, 30 entered and completed the study; the first 15 received 5 g and the next 15 received 10 g. Nonsignificant changes from baseline in urinary Na+ excretion were observed with SZC 5 g (mean ± SD −0.93 ± 25.85 mmol/24 h) and 10 g (−5.47 ± 13.90 mmol/24 h). Statistically significant decreases from baseline in urinary K+ excretion (mean ± SD −21.17 ± 21.26 mmol/24 h; P = 0.0017) and serum K+ concentration (−0.25 ± 0.24 mmol/L; P = 0.0014) were observed with the 10-g dose. There were few adverse events and no clinically meaningful changes in vital signs or laboratory safety measures.

Conclusions

Treatment with SZC 5 or 10 g QD reduced serum K+ concentration and urinary K+ excretion, with no significant effect on urinary Na+ excretion, and was well tolerated.
#MoreThanAVisitor: Families as “Essential” Care Partners During COVID-19
Authors: Kemp Candace L
Published: October 2020

The public health response to the current Coronavirus pandemic in long-term care communities, including assisted living, encompasses prohibiting visitors. This ban, which includes family members, has been criticized for being unfair, unhealthy, and unsafe. Against this backdrop, I examine the roles family play in residents’ daily lives and care routines. I argue that classifying family as “visitors” rather than essential care partners overlooks their critical contributions and stems from taken-for-granted assumption about gender, families, and care work, and I demonstrate why families are more than visitors. Policies that ban family visits also reflect a narrow understanding of health that focuses on mitigating infection risk, but neglects overall health and well-being. This policy further stems from a limited comprehension of care relations. Research shows that banning family visits has negative consequences for residents, but also families themselves, and direct care workers. I argue that identifying ways to better understand and support family involvement is essential and demonstrate the utility of the Convoys of Care model for guiding the reconceptualization of family in long-term care research, policy, and practice during and beyond the pandemic.
Geometry of Horospherical Varieties of Picard Rank One
Authors: Gonzales R , Pech C , Perrin N , Samokhin A
Published: October 2020

We study the geometry of smooth non-homogeneous horospherical varieties of Picard rank one. These have been classified by Pasquier and include the well-known odd symplectic Grassmannians. We focus our study on quantum cohomology, with a view towards Dubrovin’s conjecture. We start with describing the cohomology groups of smooth horospherical varieties of Picard rank one. We show a Chevalley formula for these and establish that many Gromov–Witten invariants are enumerative. This enables us to prove that in many cases the quantum cohomology is semisimple. We give a presentation of the quantum cohomology ring for odd symplectic Grassmannians. In the last sections, we turn to derived categories of coherent sheaves. We first discuss a general construction of exceptional bundles on horospherical varieties. We work out in detail the case of the horospherical variety associated to the exceptional group $G_2$ and construct a full rectangular Lefschetz exceptional collection in the derived category.
Differences in Factors Associated With High- and Low-Risk Oral Human Papillomavirus Genotypes in Men
Authors: Bettampadi Deepti , Dickey Brittney , Abrahamsen Martha , Sirak Bradley , Baggio Maria Luiza , Galan Lenice , Silva Roberto Carvalho , Villa Luisa , Ponce Eduardo Lazcano , Giuliano Anna R
Published: October 2020

Background

Human papillomavirus (HPV) causes oral warts and oropharyngeal cancer (OPC). Human papillomavirus-attributable OPC incidence among men is significantly increasing worldwide, yet few studies have reported oral HPV across multiple countries or examined factors associated with low- and high-risk HPV separately.

Methods

Oral gargles from 3095 men in the multinational HPV Infection in Men (HIM) Study were HPV genotyped. Multivariable models assessed factors independently associated with high-risk and low-risk HPV prevalence.

Results

The prevalence of high-risk and low-risk HPV was 6.0% and 2.8%, respectively. Greater number of sexual partners was only associated with high-risk HPV (1.88; 95% confidence interval [CI], 1.22–2.90) prevalence. In multivariable models, residing in Mexico (1.66; 95% CI, 1.15–2.40) and smoking (1.66; 95% CI, 1.13–2.44) were significantly associated with high-risk HPV, and history of consistent gum bleeding (2.16; 95% CI, 1.35–3.45) was significantly associated with low-risk HPV. Gender of the sexual partner did not alter the results for either high- or low-risk HPV endpoints.

Conclusions

Different factors were independently associated with high- and low-risk oral HPV. Oral sexual behaviors were associated with high-risk HPV, and oral health was associated with low-risk HPV. High-risk HPV prevalence differed by country of residence, highlighting the need for additional studies in multiple countries.
Patient Diversity in Breast Imaging: Barriers and Potential Solutions
Authors: Patel Miral M , Parikh Jay R
Published: October 2020

Recent reports have highlighted disparities in breast cancer care related to patient diversity. Breast radiologists represent the face of breast imaging and are key players in advocating for patients to reduce these disparities. Diversity-related barriers for breast imaging patients, as they journey from screening to survivorship, include impediments to access and quality of care, gaps in communication, and lack of knowledge in both providers and patients. Potential strategies for overcoming these specific barriers include “culturally tailored” nurse navigators, mobile mammography, improved communication, patient and provider education, and breast radiologist involvement in advocacy efforts promoting diversity. As current trends in recommendations and guidelines for breast imaging include more numerous and advanced imaging modalities, it is important to acknowledge and address diversity-related disparities.
The CTSC-RAB38 Fusion Transcript Is Associated With the Risk of Hemorrhage in Brain Arteriovenous Malformations
Authors: Yan Zihan , Fan Guangming , Li Hao , Jiao Yuming , Fu Weilun , Weng Jiancong , Huo Ran , Wang Jie , Xu Hongyuan , Wang Shuo , Cao Yong , Zhao Jizong
Published: October 2020

Brain arteriovenous malformations (bAVMs) are congenital anomalies of blood vessels that cause intracranial hemorrhage in children and young adults. Chromosomal rearrangements and fusion genes play an important role in tumor pathogenesis, though the role of fusion genes in bAVM pathophysiological processes is unclear. The aim of this study was to identify fusion transcripts in bAVMs and analyze their effects. To identify fusion transcripts associated with bAVM, RNA sequencing was performed on 73 samples, including 66 bAVM and 7 normal cerebrovascular samples, followed by STAR-Fusion analysis. Reverse transcription polymerase chain reaction and Sanger sequencing were applied to verify fusion transcripts. Functional pathway analysis was performed to identify potential effects of different fusion types. A total of 21 fusion transcripts were detected. Cathepsin C (CTSC)-Ras-Related Protein Rab-38 (RAB38) was the most common fusion and was detected in 10 of 66 (15%) bAVM samples. In CTSC-RAB38 fusion-positive samples, CTSC and RAB38 expression was significantly increased and activated immune/inflammatory signaling. Clinically, CTSC-RAB38 fusion bAVM cases had a higher hemorrhage rate than non-CTSC-RAB38 bAVM cases (p < 0.05). Our study identified recurrent CTSC-RAB38 fusion transcripts in bAVMs, which may be associated with bAVM hemorrhage by promoting immune/inflammatory signaling.
What prospects for shale gas in Asia? Case of shale gas in China
Authors: Le Minh Thong , Do Huu Tung , Nguyen Thanh Thuy , Nguyen Thi Kim Ngan
Published: October 2020

The issues of energy and the environment are one of the main challenges for humanity today. Global growth in energy demand is facing environmental concerns, especially in fast-growing regions such as Asia. Transferring traditional energy sources such as coal, oil, to cleaner energy sources and renewables is an inevitable trend in the future. With good characteristics compared to other fossil fuels, natural gas can play an essential role in the energy transition process towards a low-carbon economy. The success of the shale gas revolution in the USA has created a lot of interest globally, especially in countries with potential for these resources. Asia, especially China, is estimated to have the world's largest shale gas resource. However, the question about the development of these resources is still a big question. This article will evaluate shale gas development prospects in Asia, particularly in China, by analysing the fundamental conditions that are important factors for the success of shale gas in the USA.
Point-of-Care Testing Effectiveness on Blood Donor Hemoglobin Testing
Authors: Grech Kayleigh , Zammit Vanessa
Published: October 2020

Background

Hemoglobin (Hb) evaluation by point-of-care testing (POCT) identifies borderline or anaemic asymptomatic blood donors. Although quality control checks confirm that this device is fit for use, it is still not clear whether the analyser is performing effectively. A protocol comparing the POCT EKF Diagnostics with the Sysmex XN-550 automated cell counter (ACC) has been designed.

Methods

Various scenarios of Hb measurements from the ACC and the POCT device are compared using the Spearman correlation and Intraclass correlation. The Bland-Altman method was used to analyse the level of agreement between the two devices.

Results

Correlation between the two devices was best observed in the venous vs venous blood scenario.

Conclusion

The POCT device overestimates the Hb levels in capillary blood, meaning that Hb requirements should be adjusted and when feasible testing repeated on venous blood using an ACC. Furthermore, it is suggested thar each Facility determine their own Hb threshold.
Visual exploration of historical maps
Authors: Reckziegel Martin , Wrisley David Joseph , Hixson Taylor Wright , Jänicke Stefan
Published: October 2020

Historical maps tell rich stories, and they are also valuable data objects. They vary greatly in size, type, and context, as well as the kinds and density of information they contain. Historical maps are indeed objects that invite close reading, interpretation, and debate. Whereas a variety of environments exist for the annotation, manipulation, and representation of digital maps, or map-derived data, workflows in the spatial digital humanities can be complex and those environments are not often well integrated. In this article, we describe a prototype named ‘MapFolder’ for studying maps, its algorithms for calculating the areal distortion, its visual design for communicating that distortion, along with a scholarly workflow. We blend annotation practices common in the spatial humanities with the workflows of georeferencing in order to be able to visualize how historic cartographic documents compare with the geospatial representations we are familiar with today. The case studies we use to demonstrate ‘MapFolder’ are maps of the medieval period, a body of maps that are less often studied algorithmically and that are usually avoided in typical workflows of georeferencing. MapFolder is by no means a prototype designed to work exclusively with medieval maps, but since maps of this period are only partially geographic in their design, they offer a particularly fruitful opportunity to rethink the algorithmic manipulation of historical depictions of the world. Working with this complex data from the humanities allows us, as well, to propose the use of visualization for critical, comparative spatial analysis in pre-modern studies and beyond.
The Metal Abundances across Cosmic Time (MACT) Survey. III – The relationship between stellar mass and star formation rate in extremely low-mass galaxies
Authors: Shin Kaitlyn , Ly Chun , Malkan Matthew A , Malhotra Sangeeta , de los Reyes Mithi , Rhoads James E
Published: October 2020

Extragalactic studies have demonstrated that there is a moderately tight (≈0.3 dex) relationship between galaxy stellar mass (M⋆) and star formation rate (SFR) that holds for star-forming galaxies at M⋆ ∼ 3 × 108–1011 M⊙, i.e. the ‘star formation main sequence’. However, it has yet to be determined whether such a relationship extends to even lower mass galaxies, particularly at intermediate or higher redshifts. We present new results using observations for 714 narrow-band H α-selected galaxies with stellar masses between 106 and 1010 M⊙ (average of 108.2 M⊙) at z ≈ 0.07–0.5. These galaxies have sensitive ultraviolet (UV) to near-infrared photometric measurements and optical spectroscopy. The latter allows us to correct our H α SFRs for dust attenuation using Balmer decrements. Our study reveals that: (1) for low-SFR galaxies, our H α SFRs systematically underpredict compared to far-UV measurements, consistent with other studies; (2) at a given stellar mass (≈108 M⊙), log (specific SFR) evolves as A log (1 + z) with A = 5.26 ± 0.75, and on average, specific SFR increases with decreasing stellar mass; (3) the SFR–M⋆ relation holds for galaxies down to ∼106 M⊙ (∼1.5 dex below previous studies), and over lookback times of up to 5 Gyr, follows a redshift-dependent relation of log (SFR) ∝ α log (M⋆/M⊙) + β z with α = 0.60 ± 0.01 and β = 1.86 ± 0.07; and (4) the observed dispersion in the SFR–M⋆ relation at low stellar masses is ≈0.3 dex. Accounting for survey selection effects using simulated galaxies, we estimate that the true dispersion is ≈0.5 dex.
Simulations of globular clusters within their parent galaxies: multiple stellar populations and internal kinematics
Authors: McKenzie Madeleine , Bekki Kenji
Published: October 2020

Using three-dimensional smoothed particle hydrodynamics simulations, we investigate the formation of multiple stellar populations (MSPs) in globular clusters (GCs) within the context of their parent galaxies. In our scenario, the second generation (2G) of stars originate from both asymptotic giant branch (AGB) polluters and pristine gas accreted from the host galaxy. Previous theoretical and numerical studies have demonstrated that this ‘AGB with dilution’ model has the potential to alleviate several problems faced by the classical AGB scenario. However, the accretion of pristine gas on to the GC has yet to be investigated within the context of the parent galaxy. This paper presents the preliminary results from our original simulation code which models GC formation from giant molecular clouds in a host galaxy, and subsequent gas accretion on to the GC. By simulating the genesis of the 2G over a 370 Myr time frame, we demonstrate that the fraction of 2G stars are inextricably linked to the GC’s environment. Our simulations rationalize the wide variety of abundance patterns, kinematics, and 2G concentrations by altering the initial conditions of both the GC progenitor and the host galaxy itself. Most notably, we reproduce a positive correlation between the fraction of 2G stars and the initial mass of the cluster. We discuss the physical implications of our scenario and compare our simulations with observations of the Galactic GC 47 Tucanae (47 Tuc). Finally, we present scaling relations that encompass the wider GC population and serve as a reference for future observations.
Unveiling early black hole growth with multifrequency gravitational wave observations
Authors: Valiante Rosa , Colpi Monica , Schneider Raffaella , Mangiagli Alberto , Bonetti Matteo , Cerini Giulia , Fairhurst Stephen , Haardt Francesco , Mills Cameron , Sesana Alberto
Published: October 2020

Third-generation ground-based gravitational wave interferometers, like the Einstein Telescope (ET), Cosmic Explorer, and the Laser Interferometer Space Antenna (LISA), will detect coalescing binary black holes over a wide mass spectrum and across all cosmic epochs. We track the cosmological growth of the earliest light and heavy seeds that swiftly transit into the supermassive domain using a semi-analytical model for the formation of quasars at z = 6.4, 2, and 0.2, in which we follow black hole coalescences driven by triple interactions. We find that light-seed binaries of several $10^2 \, {\rm M_\odot }$ are accessible to ET with a signal-to-noise ratio (S/N) of 10–20 at 6 < z < 15. They then enter the LISA domain with larger S/N as they grow to a few $10^4 \, {\rm M_\odot }$. Detecting their gravitational signal would provide first time evidence that light seeds form, grow, and dynamically pair during galaxy mergers. The electromagnetic emission of accreting black holes of similar mass and redshift is too faint to be detected even for the deepest future facilities. ET will be our only chance to discover light seeds forming at cosmic dawn. At 2 < z < 8, we predict a population of ‘starved binaries’, long-lived marginally growing light-seed pairs, to be loud sources in the ET bandwidth (S/N > 20). Mergers involving heavy seeds (${\sim} 10^5\!-\!10^6 \, {\rm M_\odot }$) would be within reach up to z = 20 in the LISA frequency domain. The lower z model predicts $11.25 \, (18.7)$ ET (LISA) events per year, overall.
Exploring the hot gaseous halo around an extremely massive and relativistic jet launching spiral galaxy with XMM−Newton
Authors: Mirakhor M S , Walker S A , Bagchi J , Fabian A C , Barth A J , Combes F , Dabhade P , Ho L C , Pandge M B
Published: October 2020

We present a deep XMM−Newton observation of the extremely massive, rapidly rotating, relativistic-jet-launching spiral galaxy 2MASX J23453268−0449256. Diffuse X-ray emission from the hot gaseous halo around the galaxy is robustly detected out to a radius of 160 kpc, corresponding roughly to 35 per cent of the virial radius (≈450 kpc). We fit the X-ray emission with the standard isothermal β model, and it is found that the enclosed gas mass within 160 kpc is $1.15_{-0.24}^{+0.22} \times 10^{11} \, \rm {M}_{\odot }$. Extrapolating the gas mass profile out to the virial radius, the estimated gas mass is $8.25_{-1.77}^{+1.62} \times 10^{11} \, \rm {M}_{\odot }$, which makes up roughly 65 per cent of the total baryon mass content of the galaxy. When the stellar mass is considered and accounting for the statistical and systematic uncertainties, the baryon mass fraction within the virial radius is $0.121_{-0.043}^{+0.043}$, in agreement with the universal baryon fraction. The baryon mass fraction is consistent with all baryons falling within r200, or with only half of the baryons falling within r200. Similar to the massive spiral galaxies NGC 1961 and NGC 6753, we find a low value for the metal abundance of ≈ 0.1 Z⊙, which appears uniform with radius. We also detect diffuse X-ray emission associated with the northern and southern lobes, possibly attributed to inverse Compton scattering of cosmic microwave background photons. The estimated energy densities of the electrons and magnetic field in these radio lobes suggest that they are electron-dominated by a factor of 10−200, depending on the choice of the lower cut-off energy of the electron spectrum.
Urinary mulberry bodies as a potential biomarker for early diagnosis and efficacy assessment of enzyme replacement therapy in Fabry nephropathy
Authors: Yonishi Hiroaki , Namba-Hamano Tomoko , Hamano Takayuki , Hotta Masaki , Nakamura Jun , Sakai Shinsuke , Minami Satoshi , Yamamoto Takeshi , Takahashi Atsushi , Kobayashi Wataru , Maeda Ikuhiro , Hidaka Yoh , Takabatake Yoshitsugu , Sakai Norio , Isaka Yoshitaka
Published: October 2020

Background

The inability of enzyme replacement therapy (ERT) to prevent progression of Fabry nephropathy (FN) in the presence of >1 g/day proteinuria underscores the necessity of identifying effective biomarkers for early diagnosis of FN preceding proteinuria. Here we attempted to identify biomarkers for early detection of FN.

Methods

Fifty-one Fabry disease (FD) patients were enrolled. Urinary mulberry bodies (uMBs) were immunostained for globotriaosylceramide (Gb3) and renal cell markers to determine their origin. The association between semiquantitative uMB excretion and the histological severity of podocyte vacuolation was investigated in seven patients using the vacuolated podocyte:glomerular average area ratio. The association between the semiquantitative estimate of uMB excretion and duration of ERT was analyzed. A longitudinal study was conducted to assess the effect of ERT on uMB excretion.

Results

Thirty-two patients (63%) had uMBs, while only 31% showed proteinuria. The uMBs were positive for Gb3, lysosomal-associated membrane protein 1 and podocalyxin, suggesting they were derived from lysosomes with Gb3 accumulation in podocytes. We observed more severe podocyte vacuolation with increased uMB excretion (P = 0.03 for trend); however, the same was not observed with increased proteinuria. The percentage of patients with substantial uMB excretion increased with shorter ERT duration (P = 0.018). Eighteen-month-long ERT reduced uMB excretion (P = 0.03) without affecting proteinuria.

Conclusions

uMB excretion, implying ongoing podocyte injury, preceded proteinuria in most patients. Semiquantitative uMB estimates can serve as novel biomarkers for early FN diagnosis and for monitoring the efficacy of FD-specific therapies.
Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease
Authors: Cardozo Ludmila F M F , Alvarenga Livia A , Ribeiro Marcia , Dai Lu , Shiels Paul G , Stenvinkel Peter , Lindholm Bengt , Mafra Denise
Published: October 2020

Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables (Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 (Nrf2), considered a master regulator of cellular antioxidant responses. Patients with chronic diseases, such as diabetes, cardiovascular disease, cancer, and chronic kidney disease (CKD) present with high levels of oxidative stress and a massive inflammatory burden associated with diminished Nrf2 and elevated nuclear transcription factor-κB-κB expression. Because it is a common constituent of dietary vegetables, the salutogenic properties of sulforaphane, especially it’s antioxidative and anti-inflammatory properties, have been explored as a nutritional intervention in a range of diseases of ageing, though data on CKD remain scarce. In this brief review, the effects of SFN as a senotherapeutic agent are described and a rationale is provided for studies that aim to explore the potential benefits of SFN-rich foods in patients with CKD.
Association between seasonal flu vaccination and COVID-19 among healthcare workers
Authors: Belingheri M , Paladino M E , Latocca R , De Vito G , Riva M A
Published: October 2020

Background

In next fall and winter, SARS-CoV-2 could circulate in parallel with seasonal influenza. The dual epidemics will result in considerable morbidity and mortality; therefore, influenza vaccination may be essential. Recent studies found increased risk of coronavirus in individuals receiving influenza vaccination.

Aims

Our aim is to analyse the association between influenza vaccination and COVID-19 in a population of healthcare workers (HCWs).

Methods

IgG antibodies against SARS-CoV-2 were detected in 3520 HCWs at a large hospital in Northern Italy. For each participant, we collected data on flu immunization status for the last five flu seasons. Logistic regression was used to test associations between seasonal flu vaccination status and a positive serology tests for COVID-19.

Results

During the last five flu seasons, 2492 vaccinations were administered. Serology tests were negative for 3196 (91%) HCWs and residents and only 21 (1%) people had an equivocal test (12.0–15.0 AU/mL). Only 128 (4%) people received a diagnosis of COVID-19, with a positive swab test. No flu vaccinations for the last five flu seasons were specifically associated with diagnosis of COVID-19 or with positive results of serology tests.

Conclusions

Flu vaccinations did not appear to be associated with SARS-CoV-2 infection. Influenza vaccination should continue to be recommended for HCWs and for individuals at increased risk for severe illness from respiratory infection.
Wages and Firm Performance: Evidence from the 2008 Financial Crisis
Authors: Ouimet Paige , Simintzi Elena
Published: October 2020

We examine the effect of higher wages on firm performance during the 2008 financial crisis. To identify variation in wages, we rely on heterogeneity in the timing of long-term wage agreements for a sample of U.K. firms. We instrument for firms signing long-term agreements overlapping with the crisis by the presence of a contract signed in 2006 or earlier and expiring before September 2008. Treated firms not only paid higher wages but also realized greater labor productivity relative to control firms. These findings are consistent with the intuition that opportunity cost differentials between treated and control firms induce employees to exert higher effort. (JEL J41, J30, J24, G01)

Received February 28, 2019; editorial decision July 8, 2020 by Editor Andrew Ellul. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Common Ownership and Corporate Social Responsibility
Authors: Dai Xin , Qiu Yue
Published: October 2020

This paper studies the effect of common ownership on corporate social responsibility (CSR). We find that common ownership is positively associated with a firm’s CSR score. The effect is stronger for firms in more competitive industries. We propose a two-stage duopoly game in which CSR serves as a commitment device to expand output aggressively to understand the empirical results. (JEL G30, D21, D22, L13, L21, L22)

Received December 10, 2019; editorial decision September 9, 2020 by Editor: Gregor Matvos. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27
Authors: Pan Lu , Wang Jinghua , Liu Jinxiang , Guo Lishuang , Yang Sirui
Published: October 2020

Objective

Type 1 regulatory T (Tr1) cells are involved in the pathogenesis of numerous immune-mediated diseases. However, little is known about whether and how Tr1 cells affect the development of IgA vasculitis (IgAV). We aimed to investigate this question in IgAV patients.

Methods

. Tr1 cells in peripheral blood and kidney tissue of IgAV patients were analysed by multi-parametric flow cytometry and immunofluorescence techniques. An in vitro assay of suppression of T cell proliferation and cytokine release was performed to evaluate the function of Tr1 cells. Real-time PCR and cell stimulation in vitro were used to explore the roles of IL-27 and early growth response gene 2 (EGR2).

Results

The frequency of Tr1 cells was decreased in peripheral blood but increased in kidney tissue from IgAV patients. A defective suppressive function of Tr1 cells in IgAV was observed. The frequency of Tr1 cells and the cytokines secreted by them were up-regulated in the presence of recombinant IL-27 in vitro. Moreover, IL-27 also increased the expression of EGR2. Furthermore, lower frequency of Tr1 cells during remission had a higher recurrence rate.

Conclusion

Tr1 cells are involved in the pathogenesis of IgAV. The low IL-27 in IgAV is responsible for impaired frequency and function of Tr1 cells, and EGR2 may be the specific transcription factor involved in the progression. Tr1 may be a risk factor for IgAV recurrence.
Socioeconomic status and occurrence of chronic pain: a meta-analysis
Authors: Prego-Domínguez Jesús , Khazaeipour Zahra , Mallah Narmeen , Takkouche Bahi
Published: October 2020

Objective

To examine the association between socioeconomic status (SES) and the occurrence of chronic pain, defined as pain that persists or recurs for >3 months.

Methods

We performed a structured search in Medline, Embase, WHO Global Index Medicus and Conference Proceedings Citation Index-Science databases to identify cohort and case–control studies on chronic pain and SES and its subgroups (SES combined index, educational level, income and occupational status). We extracted study characteristics, outcome measures and measures of association and their 95% CIs. Literature search, data extraction and risk of bias assessment were conducted by two independent researchers. We performed main and subgroup meta-analyses using random-effects model, and formally assessed heterogeneity and publication bias.

Results

A total of 45 studies, covering a population of ∼175 000 individuals, were meta-analysed, yielding a pooled Odds Ratio (OR) of 1.32 (95% CI: 1.21, 1.44) and 1.16 (95% CI: 1.09, 1.23) for low and medium SES levels, respectively, compared with high level. We obtained similar results in all the subgroup analyses. Heterogeneity was generally moderate to high across strata, and some evidence of publication bias for low socioeconomic status was found.

Conclusion

Our results support a moderate increase in the risk of chronic pain for low and medium SES when compared with high SES, a feature that remained constant in all measures of exposure or outcome used. Further prospective research on populations from developing countries are needed to confirm our findings as the studies available for this meta-analysis were carried out exclusively in developed countries.
Political Epistemology in Gender Policy-Making: The German Democratization of Expertise
Authors: Kulawik Teresa
Published: October 2020

This article proposes the concept of feminist political epistemology to examine the changing modalities of knowledge production in Germany. The article examines how German gender equality policies have been embedded in and shaped by the shifting modalities of knowledge production and the remaking of the science expertise–politics nexus. The two formative time periods investigated—the 1960s–1970s and 1998 to the present—account for major shifts in the gender and political knowledge regime in Germany. The findings provide insights into the contradictory dynamics involved in transformations of political and epistemic authority.
The U.S. Safety Net since the Great Recession: Trends and Reforms, 2007–2017
Authors: Chang Yu-Ling , Romich Jennifer L
Published: October 2020

The negative impacts of the Great Recession (GR) (2007 to 2009) on the lives of families with low incomes warrant social work concerns about how well antipoverty policy responded to meet economic needs over this period and since. Given America’s long-standing tension between welfare state adequacy and market-oriented policies, how well did the safety net respond to the economic downturn? Did GR-era changes reverse or accelerate trends in public assistance? This article examines key policy changes and indicators of caseloads, inclusion, and generosity for three antipoverty policies: the Temporary Assistance for Needy Families, the Supplemental Nutrition Assistance Program (SNAP, formerly Food Stamp Program), and the Earned Income Tax Credit from 2007 to 2017. Authors’ analysis shows a continuation of market-oriented U.S. antipoverty policy. Authors argue that the reemphasis of conditioning benefits on employment undermines the countercyclical feature of the social safety net and perpetuates the inequitable redistribution of public resources between those inside and outside of the labor market. Authors discuss social workers’ role in strengthening antipoverty policies to improve the economic well-being of people with low incomes and the economic justice of the social safety net.
Pension funds, quasi-trustees and statutory guidance
Authors: Akhtar Zia
Published: October 2020

In an important decision for public law, the Supreme Court has ruled that ministerial guidance, given to administering authorities to oversee investment of Local Government Pension Scheme (LGPS) funds on how to discharge their powers, is unlawful. All five judges accepted that administering authorities owe “quasi-trustee” duties to LGPS members (in the area of investment) and that, as the law stands, the Secretary of State’s powers are limited by these overriding duties. However, only three judges accepted that the Public Service Pensions Act 2013 did not allow central government policy to be “imposed” on LGPS funds. The two dissenting judges stated that the public interest component of the 2013 Act was significant, and, under certain circumstances, central government could legitimately seek to align LGPS fund investment with government policy. The consequence of the ruling is that the Government will not be able to interfere in the ethical investment decisions of LGPS and their members, and the principle from the Padfield case that a discretionary power granted in legislation can never be completely unfettered and must be exercised in accordance with the purpose of the legislation has been upheld.