bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced Electrochemical Water Oxidation Activity by Structural Engineered Prussian Blue Analogue/rGO Heterostructure
Authors: An Xiuyun , Zhu Weili , Tang Chunjuan , Liu Lina , Chen Tianwei , Wang Xiaohu , Zhao Jianguo , Zhang Guanhua
Published: August 2022

Prussian blue analogue (PBA), with a three-dimensional open skeleton and abundant unsaturated surface coordination atoms, attracts extensive research interest in electrochemical energy-related fields due to facile preparation, low cost, and adjustable components. However, it remains a challenge to directly employ PBA as an electrocatalyst for water splitting owing to their poor charge transport ability and electrochemical stability. Herein, the PBA/rGO heterostructure is constructed based on structural engineering. Graphene not only improves the charge transfer efficiency of the compound material but also provides confined growth sites for PBA. Furthermore, the charge transfer interaction between the heterostructure interfaces facilitates the electrocatalytic oxygen evolution reaction of the composite, which is confirmed by the results of the electrochemical measurements. The overpotential of the PBA/rGO material is only 331.5 mV at a current density of 30 mA cm−2 in 1.0 M KOH electrolyte with a small Tafel slope of 57.9 mV dec−1, and the compound material exhibits high durability lasting for 40 h.
Nanoporous Stainless Steel Materials for Body Implants—Review of Synthesizing Procedures
Authors: Benčina Metka , Junkar Ita , Vesel Alenka , Mozetič Miran , Iglič Aleš
Published: August 2022

Despite the inadequate biocompatibility, medical-grade stainless steel materials have been used as body implants for decades. The desired biological response of surfaces to specific applications in the body is a highly challenging task, and usually not all the requirements of a biomaterial can be achieved. In recent years, nanostructured surfaces have shown intriguing results as cell selectivity can be achieved by specific surface nanofeatures. Nanoporous structures can be fabricated by anodic oxidation, which has been widely studied for titanium and its alloys, while no systematic studies are so far available for stainless steel (SS) materials. This paper reviews the current state of the art in the anodisation of SS; correlations between the parameters of anodic oxidation and the surface morphology are drawn. The results reported by various authors are scattered because of a variety of experimental configurations. A linear correlation between the pores’ diameter anodisation voltage was deduced, while no correlation with other processing parameters was found obvious. The analyses of available data indicated a lack of systematic experiments, which are recommended to understand the kinetics of pore formation and develop techniques for optimal biocompatibility of stainless steel.
Bio-Based Carbon Materials for High-Performance Supercapacitors
Authors: Li Penghui , Yang Chi , Wu Caiwen , Wei Yumeng , Jiang Bo , Jin Yongcan , Wu Wenjuan
Published: August 2022

Lignin, one of the components of natural plant biomass, is a rich source of carbon and has excellent potential as a valuable, sustainable source of carbon material. Low-cost lignosulfonate (LS) doped with polyaniline (PANI) has been used as a precursor to produce porous carbon. LS has a highly dispersed and sparse microstructure and can be accidentally doped with S atoms. N and S double-doped carbon can be directly synthesized with abundant mesopores and high surface area in a lamellar network using PANI as another doping source. This study explored the optimal conditions of LS/PANI material with different amounts of lignosulfonate and different carbonization temperatures. When the amount of lignosulfonate was 4 g and the carbonization temperature was 700 °C, graded porous carbon was obtained, and the electrochemical performance was the best. At 0.5 A/g, the specific capacitance reached 333.50 F/g (three-electrode system) and 242.20 F/g (two-electrode system). After 5000 charge/discharge cycles at 5 A/g, the material maintained good cycling stability and achieved a capacitance retention rate of 95.14% (three-electrode system) and 97.04% (two-electrode system). The energy and power densities of the SNC700 samples were 8.33 Wh/kg and 62.5 W/kg at 0.25 A/g, respectively, values that meet the requirements of today’s commercially available supercapacitor electrode materials, further demonstrating their good practicality. This paper provides an efficient double-doping method to prepare layered structures. Porous carbon is used for electrochemical energy storage devices.
Electrospun Chitosan–Polyvinyl Alcohol Nanofiber Dressings Loaded with Bioactive Ursolic Acid Promoting Diabetic Wound Healing
Authors: Lv Hongyu , Zhao Meng , Li Yiran , Li Kun , Chen Shaojuan , Zhao Wenwen , Wu Shaohua , Han Yantao
Published: August 2022

The design and development of novel dressing materials are urgently required for the treatment of chronic wounds caused by diabetic ulcers in clinics. In this study, ursolic acid (UA) extracted from Chinese herbal plants was encapsulated into electrospun nanofibers made from a blend of chitosan (CS) and polyvinyl alcohol (PVA) to generate innovative CS-PVA-UA dressings for diabetic wound treatment. The as-prepared CS-PVA-UA nanofiber mats exhibited randomly aligned fiber morphology with the mean fiber diameters in the range of 100–200 nm, possessing great morphological resemblance to the collagen fibrils which exist in the native skin extracellular matrix (ECM). In addition, the CS-PVA-UA nanofiber mats were found to possess good surface hydrophilicity and wettability, and sustained UA release behavior. The in vitro biological tests showed that the high concentration of UA could lead to slight cytotoxicity. It was also found that the CS-PVA-UA nanofiber dressings could significantly reduce the M1 phenotypic transition of macrophages that was even stimulated by lipopolysaccharide (LPS) and could effectively restore the M2 polarization of macrophages to shorten the inflammatory period. Moreover, the appropriate introduction of UA into CS-PVA nanofibers decreased the release levels of TNF-α and IL-6 inflammatory factors, and suppressed oxidative stress responses by reducing the generation of reactive oxygen species (ROS) as well. The results from mouse hepatic hemorrhage displayed that CS-PVA-UA nanofiber dressing possessed excellent hemostatic performance. The in vivo animal experiments displayed that the CS-PVA-UA nanofiber dressing could improve the closure rate, and also promote the revascularization and re-epithelization, as well as the deposition and remodeling of collagen matrix and the regeneration of hair follicles for diabetic wounds. Specifically, the mean contraction rate of diabetic wounds using CS-PVA-UA nanofiber dressing could reach 99.8% after 18 days of treatment. In summary, our present study offers a promising nanofibrous dressing candidate with multiple biological functions, including anti-inflammation, antioxidation, pro-angiogenesis, and hemostasis functions, for the treatment of hard-to-heal diabetic wounds.
Conductive Inks Based on Melamine Intercalated Graphene Nanosheets for Inkjet Printed Flexible Electronics
Authors: Kralj Magdalena , Krivačić Sara , Ivanišević Irena , Zubak Marko , Supina Antonio , Marciuš Marijan , Halasz Ivan , Kassal Petar
Published: August 2022

With the growing number of flexible electronics applications, environmentally benign ways of mass-producing graphene electronics are sought. In this study, we present a scalable mechanochemical route for the exfoliation of graphite in a planetary ball mill with melamine to form melamine-intercalated graphene nanosheets (M-GNS). M-GNS morphology was evaluated, revealing small particles, down to 14 nm in diameter and 0.4 nm thick. The M-GNS were used as a functional material in the formulation of an inkjet-printable conductive ink, based on green solvents: water, ethanol, and ethylene glycol. The ink satisfied restrictions regarding stability and nanoparticle size; in addition, it was successfully inkjet printed on plastic sheets. Thermal and photonic post-print processing were evaluated as a means of reducing the electrical resistance of the printed features. Minimal sheet resistance values (5 kΩ/sq for 10 printed layers and 626 Ω/sq for 20 printed layers) were obtained on polyimide sheets, after thermal annealing for 1 h at 400 °C and a subsequent single intense pulsed light flash. Lastly, a proof-of-concept simple flexible printed circuit consisting of a battery-powered LED was realized. The demonstrated approach presents an environmentally friendly alternative to mass-producing graphene-based printed flexible electronics.
PLC-Based Arrayed Waveguide Grating Design for Fiber Bragg Grating Interrogation System
Authors: Li Ke , Yuan Pei , Lu Lidan , Dong Mingli , Zhu Lianqing
Published: August 2022

A fiber Bragg grating (FBG) interrogator is a scientific instrument that converts the wavelength change of FBG sensors into readable electrical signals. To achieve miniaturization and integration of FBG interrogator, we designed and fabricated a 36-channel array waveguide grating (AWG) on silica-based planar lightwave circuits (PLC) as a key device in a built FBG interrogation system. It is used to achieve continuous demodulation in C-band, while maintaining high resolution. This AWG has a 1.6 nm channel spacing, 3-dB bandwidth of 1.76 nm, non-adjacent channel crosstalk of −29.76 dB, and insertion loss of 3.46 dB. The dynamic range of the FBG interrogation system we built was tested to be 1522.4–1578.4 nm, with an interrogation resolution of 1 pm and accuracy of less than 1 pm in the dynamic range of 1523.16–1523.2 nm. The test results show that the FBG interrogation technology, based on AWG, can realize FBG wavelengths accurately demodulated, which has high application value in aerospace, deep sea exploration, and environmental monitoring, as well as other fields.
Early and Long-Term Effects of Abdominal Fat Reduction Using Ultrasound and Radiofrequency Treatments
Authors: Kiedrowicz Magdalena , Duchnik Ewa , Wesołowska Jolanta , Bania Beata , Peregud-Pogorzelska Małgorzata , Maciejewska-Markiewicz Dominika , Stachowska Ewa , Kruk Joanna , Marchlewicz Mariola
Published: August 2022

Background: Abdominal obesity, together with atherogenic dyslipidemia, increased blood pressure and impaired glucose tolerance, was included in the components of metabolic syndrome identifying patients at high risk of cardiovascular diseases. Subcutaneous adipose tissue is a buffer for dietary fatty acids (FAs). It was reported that the fatty acid composition of adipose tissue reflects the dietary intake of FAs in the previous 6 to 9 months. Therefore, we decided to evaluate the early and long-term metabolic effects of lipocavitation and/or thermolipolysis on abdominal fat reduction. Material and Methods: The study population comprised 60 women. Subjects were randomly allocated into one of three subgroups, 20 women per subgroup, and each subgroup received 10 treatments with ultrasound (U group), radiofrequency (RF group), or combined radiofrequency and ultrasound (RF/U group) for the abdominal region. Treatments were provided three times a week using the multifunctional device (Professional Beauty Equipment, HEBE, Warsaw, Poland). Each treatment to reduce adipose tissue, regardless of the method used, involved 20 min of massage with the dedicated applicator head on a rectangular 20 cm × 10 cm area of the abdominal region. Fatty acid composition and biochemical and anthropometric parameters were measured before the first, after 10 treatments and 6 months after the last treatment. Results and discussion: The series of 10 treatments to reduce abdominal adipose tissue using ultrasound, radiofrequency or both methods resulted in a cosmetic effect which was reflected in weight loss and BMI reduction. Reduced waist circumference was also found in patients who received radiofrequency or two types of intervention (RF + U) but not ultrasound treatments. The long-term cosmetic effect (lasting for at least 6 months) was achieved only with RF treatment and was reflected in reduced body weight, BMI and waist circumference. None of the treatments had a direct, short or long-term effect on the lipid profile, insulin resistance markers, inflammation markers, or blood pressure. Consequently, did not modify the risk of cardiovascular diseases.
Screening of Thymoquinone Content in Commercial Nigella sativa Products to Identify a Promising and Safe Study Medication
Authors: Khaikin Elisabeth , Chrubasik-Hausmann Sigrun , Kaya Sebahat , Zimmermann Benno F.
Published: August 2022

(1) Background: Thymoquinone (TQ) is the leading compound accounting for the pharmacological effects of Nigella sativa seed oil, also known as black seed oil. This study aimed to analyze the TQ content of commercial black seed oils and black seed oil-containing capsules to obtain information on the quality of the products and to find a promising and safe study medication for a putative clinical study. (2) Methods: Six black seed oils and five black seed oil-containing capsules were analyzed. TQ was quantified using a validated method consisting of a simple methanolic extraction and a fast HPLC-UV analysis. (3) Results: The TQ content varied from 3.08 to 809.4 mg/100 g (mean). The highest TQ content was found in a bottled oil, which might be considered for a clinical study. A dose of 4 mL of this oil per day contains 30 mg TQ, which is unlikely to be harmful. Based on the literature, a safe daily TQ dosage appears to be <48.6 mg per adult. (4) Conclusions: These findings suggest that black seed products should be regulated regarding TQ content to enable consumers to buy black seed food supplements of known content for the maintenance and improvement of health.
The Ukraine–Russia War Is Deepening Food Insecurity, Unhealthy Dietary Patterns and the Lack of Dietary Diversity in Lebanon: Prevalence, Correlates and Findings from a National Cross-Sectional Study
Authors: Yazbeck Nour , Mansour Rania , Salame Hassan , Chahine Nazih Bou , Hoteit Maha
Published: August 2022

Background: Due to Russia and Ukraine’s key roles in supplying cereals and oilseeds, the Russia–Ukraine war intensifies the current food availability and price challenges in Lebanon, which is a major wheat importer. Given these constraints, we conducted this study to assess the prevalence and correlates of food insecurity, low dietary diversity (DD), unhealthy dietary patterns, and the shifts in households’ food-related habits in response to the Russia–Ukraine war among a representative sample of Lebanese household’s members aged 18 years and above (N = 914). Methods: Data were collected between June and July 2022 using self-administered questionnaires; Results: Findings showed that nearly half of the households consume an undiversified diet (46%), and 55.3% ate fewer than two meals per day. The prevalence of food insecurity among Lebanese households was 74%, with one in every four households being severely food insecure. In addition, the majority of households’ members went out shopping and purchased food less than the pre-war period (68.7% and 70.3%, respectively). Furthermore, almost 68.3% of households’ members highlighted price increases for cereal products, which were the least available and most stocked items. Findings obtained through binary logistic regression also showed that food insecurity was two times higher among households with low monthly income, 35% higher among females, and three times higher among married participants; Conclusions: The impact of the Russia–Ukraine conflict on food security in Lebanon requires a systems-thinking approach as well as international effort to understand the challenges and find solutions to minimize the war’s negative effects.
Prevalence of Gastrointestinal Symptoms in Chinese Community-Dwelling Adults with and without Diabetes
Authors: Sang Miaomiao , Wu Tongzhi , Zhou Xiaoying , Horowitz Michael , Jones Karen L. , Qiu Shanhu , Guo Haijian , Wang Bei , Wang Donglei , Rayner Christopher K. , Sun Zilin
Published: August 2022

Background: Gastrointestinal symptoms have been reported to occur frequently in diabetes, but their prevalence in Chinese community-dwelling individuals with diabetes is unknown. The present study aimed to address this issue and explore the risk factors for gastrointestinal symptoms. Methods: A total of 1304 community-dwelling participants (214 with diabetes, 360 with prediabetes and 730 with normoglycemia) were surveyed for gastrointestinal symptoms using the Diabetes Bowel Symptom Questionnaire. Logistic regression analyses were applied to identify risk factors for gastrointestinal symptoms. Results: Of the overall study population, 18.6% reported at least one gastrointestinal symptom, without a significant difference between subjects with normoglycemia (17.7%), prediabetes (19.7%) and diabetes (20.1%). In all three groups, lower gastrointestinal symptoms, particularly diarrhea and constipation, were the most frequent. There was an interaction between age (≥65 years) and diabetes on the prevalence of at least one gastrointestinal symptom (p = 0.01) and of constipation (p = 0.004), with these being most frequent in subjects with diabetes aged ≥ 65 years. After multivariable adjustment, female gender and older age were associated with increased odds of at least one gastrointestinal symptom, specifically lower gastrointestinal symptoms. Older age was also associated with an increase in upper gastrointestinal symptoms. Conclusions: Gastrointestinal symptoms are common in Chinese community-dwelling adults with and without diabetes. Females, and the elderly with diabetes, are at an increased risk of symptoms.
Identifying the Determinants of Distribution of Oncomelania hupensis Based on Geographically and Temporally Weighted Regression Model along the Yangtze River in China
Authors: Wang Zhe , Liu Lu , Shi Liang , Wang Xinyao , Zhang Jianfeng , Li Wei , Yang Kun
Published: August 2022

Background: As the unique intermediate host of Schistosoma japonicum, the geographical distribution of Oncomelania hupensis (O. hupensis) is an important index in the schistosomiasis surveillance system. This study comprehensively analyzed the pattern of snail distribution along the Yangtze River in Jiangsu Province and identified the dynamic determinants of the distribution of O. hupensis. Methods: Snail data from 2017 to 2021 in three cities (Nanjing, Zhenjiang, and Yangzhou) along the Yangtze River were obtained from the annual cross-sectional survey produced by the Jiangsu Institute of Parasitic Diseases. Spatial autocorrelation and hot-spot analysis were implemented to detect the spatio–temporal dynamics of O. hupensis distribution. Furthermore, 12 factors were used as independent variables to construct an ordinary least squares (OLS) model, a geographically weighted regression (GWR) model, and a geographically and temporally weighted regression (GTWR) model to identify the determinants of the distribution of O. hupensis. The adjusted coefficients of determination (adjusted R2, AICc, RSS) were used to evaluate the performance of the models. Results: In general, the distribution of O. hupensis had significant spatial aggregation in the past five years, and the density of O. hupensis increased eastwards in the Jiangsu section of the lower reaches of the Yangtze River. Relatively speaking, the distribution of O. hupensis wase spatially clustered from 2017 to 2021, that is, it was found that the border between Yangzhou and Zhenjiang was the high density agglomeration area of O. hupensis snails. According to the GTWR model, the density of O. hupensis was related to the normalized difference vegetation index, wetness, dryness, land surface temperature, elevation, slope, and distance to nearest river, which had a good explanatory power for the snail data in Yangzhou City (adjusted R2 = 0.7039, AICc = 29.10, RSS = 6.81). Conclusions: The distribution of O. hupensis and the environmental factors in the Jiangsu section of the lower reaches of the Yangtze River had significant spatial aggregation. In different areas, the determinants affecting the distribution of O. hupensis were different, which could provide a scientific basis for precise prevention and control of O. hupensis. A GTWR model was prepared and used to identify the dynamic determinants for the distribution of O. hupensis and contribute to the national programs of control of schistosomiasis and other snail-borne diseases.
Molecular Mimicry between SARS-CoV-2 and Human Endocrinocytes: A Prerequisite of Post-COVID-19 Endocrine Autoimmunity?
Authors: Churilov Leonid P. , Normatov Muslimbek G. , Utekhin Vladimir J.
Published: August 2022

Molecular mimicry between human and microbial/viral/parasite peptides is common and has long been associated with the etiology of autoimmune disorders provoked by exogenous pathogens. A growing body of evidence accumulated in recent years suggests a strong correlation between SARS-CoV-2 infection and autoimmunity. The article analyzes the immunogenic potential of the peptides shared between the SARS-CoV-2 spike glycoprotein (S-protein) and antigens of human endocrinocytes involved in most common autoimmune endocrinopathies. A total of 14 pentapeptides shared by the SARS-CoV-2 S-protein, thyroid, pituitary, adrenal cortex autoantigens and beta-cells of the islets of Langerhans were identified, all of them belong to the immunoreactive epitopes of SARS-CoV-2. The discussion of the findings relates the results to the clinical correlates of COVID-19-associated autoimmune endocrinopathies. The most common of these illnesses is an autoimmune thyroid disease, so the majority of shared pentapeptides belong to the marker autoantigens of this disease. The most important in pathogenesis of severe COVID-19, according to the authors, may be autoimmunity against adrenals because their adequate response prevents excessive systemic action of the inflammatory mediators causing cytokine storm and hemodynamic shock. A critique of the antigenic mimicry concept is given with an assertion that peptide sharing is not a guarantee but only a prerequisite for provoking autoimmunity based on the molecular mimicry. The latter event occurs in carriers of certain HLA haplotypes and when a shared peptide is only used in antigen processing
Fmoc-Diphenylalanine Hydrogels: Optimization of Preparation Methods and Structural Insights
Authors: Diaferia Carlo , Rosa Elisabetta , Morelli Giancarlo , Accardo Antonella
Published: August 2022

Hydrogels (HGs) are tri-dimensional materials with a non-Newtonian flow behaviour formed by networks able to encapsulate high amounts of water or other biological fluids. They can be prepared using both synthetic or natural polymers and their mechanical and functional properties may change according to the preparation method, the solvent, the pH, and to others experimental parameters. Recently, many short and ultra-short peptides have been investigated as building blocks for the formulation of biocompatible hydrogels suitable for different biomedical applications. Due to its simplicity and capability to gel in physiological conditions, Fmoc-FF dipeptide is one of the most studied peptide hydrogelators. Although its identification dates to 15 ago, its behaviour is currently studied because of the observation that the final material obtained is deeply dependent on the preparation method. To collect information about their formulation, here are reported some different strategies adopted until now for the Fmoc-FF HG preparation, noting the changes in the structural arrangement and behaviour in terms of stiffness, matrix porosity, and stability induced by the different formulation strategy on the final material.
The MEK1/2 Inhibitor ATR-002 (Zapnometinib) Synergistically Potentiates the Antiviral Effect of Direct-Acting Anti-SARS-CoV-2 Drugs
Authors: Schreiber André , Ambrosy Benjamin , Planz Oliver , Schloer Sebastian , Rescher Ursula , Ludwig Stephan
Published: August 2022

The coronavirus disease 2019 (COVID-19) represents a global public health burden. In addition to vaccination, safe and efficient antiviral treatment strategies to restrict the viral spread within the patient are urgently needed. An alternative approach to a single-drug therapy is the combinatory use of virus- and host-targeted antivirals, leading to a synergistic boost of the drugs’ impact. In this study, we investigated the property of the MEK1/2 inhibitor ATR-002’s (zapnometinib) ability to potentiate the effect of direct-acting antivirals (DAA) against SARS-CoV-2 on viral replication. Treatment combinations of ATR-002 with nucleoside inhibitors Molnupiravir and Remdesivir or 3C-like protease inhibitors Nirmatrelvir and Ritonavir, the ingredients of the drug Paxlovid, were examined in Calu-3 cells to evaluate the advantage of their combinatory use against a SARS-CoV-2 infection. Synergistic effects could be observed for all tested combinations of ATR-002 with DAAs, as calculated by four different reference models in a concentration range that was very well-tolerated by the cells. Our results show that ATR-002 has the potential to act synergistically in combination with direct-acting antivirals, allowing for a reduction in the effective concentrations of the individual drugs and reducing side effects.
Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3
Authors: Oroujeni Maryam , Bezverkhniaia Ekaterina A. , Xu Tianqi , Liu Yongsheng , Plotnikov Evgenii V. , Karlberg Ida , Ryer Eva , Orlova Anna , Tolmachev Vladimir , Frejd Fredrik Y.
Published: August 2022

Radionuclide molecular imaging could provide an accurate assessment of the expression of molecular targets in disseminated cancers enabling stratification of patients for specific therapies. B7-H3 (CD276) is a transmembrane protein belonging to the B7 superfamily. This protein is overexpressed in different types of human malignancies and such upregulation is generally associated with a poor clinical prognosis. In this study, targeting properties of an Affibody-based probe, AC12, containing a -GGGC amino acid sequence as a chelator (designated as AC12-GGGC) labelled with technetium-99m (99mTc) were evaluated for imaging of B7-H3-expressing tumours. AC12-GGGC was efficiently labelled with 99mTc. [99mTc]Tc-AC12-GGGC bound specifically to B7-H3 expressing cells in vitro with affinities in nanomolar range. In mice bearing B7-H3-expressing xenografts, [99mTc]Tc-AC12-GGGC showed tumour uptake of 2.1 ± 0.5 %ID/g at 2 h after injection. Its clearance from blood, normal organs and tissues was very rapid. This new targeting agent, [99mTc]Tc-AC12-GGGC, provided high tumour-to-blood ratio already at 2 h (8.2 ± 1.9), which increased to 11.0 ± 0.5 at 4 h after injection. Significantly (p < 0.05) higher tumour-to-liver and higher tumour-to-bone ratios at 2 h in comparison with 4 h after injection were observed. Thus, [99mTc]Tc-AC12-GGGC could be a promising candidate for further development.
Kinase Inhibition in Multiple Myeloma: Current Scenario and Clinical Perspectives
Authors: Barreto Igor Valentim , Machado Caio Bezerra , Almeida Davi Benevides , Pessoa Flávia Melo Cunha de Pinho , Gadelha Renan Brito , Pantoja Laudreísa da Costa , Oliveira Deivide de Sousa , Ribeiro Rodrigo Monteiro , Lopes Germison Silva , de Moraes Filho Manoel Odorico , de Moraes Maria Elisabete Amaral , Khayat André Salim , de Oliveira Edivaldo Herculano Correa , Moreira-Nunes Caroline Aquino
Published: August 2022

Multiple myeloma (MM) is a blood cell neoplasm characterized by excessive production of malignant monoclonal plasma cells (activated B lymphocytes) by the bone marrow, which end up synthesizing antibodies or antibody fragments, called M proteins, in excess. The accumulation of this production, both cells themselves and of the immunoglobulins, causes a series of problems for the patient, of a systemic and local nature, such as blood hyperviscosity, renal failure, anemia, bone lesions, and infections due to compromised immunity. MM is the third most common hematological neoplasm, constituting 1% of all cancer cases, and is a disease that is difficult to treat, still being considered an incurable disease. The treatments currently available cannot cure the patient, but only extend their lifespan, and the main and most effective alternative is autologous hematopoietic stem cell transplantation, but not every patient is eligible, often due to age and pre-existing comorbidities. In this context, the search for new therapies that can bring better results to patients is of utmost importance. Protein tyrosine kinases (PTKs) are involved in several biological processes, such as cell growth regulation and proliferation, thus, mutations that affect their functionality can have a great impact on crucial molecular pathways in the cells, leading to tumorigenesis. In the past couple of decades, the use of small-molecule inhibitors, which include tyrosine kinase inhibitors (TKIs), has been a hallmark in the treatment of hematological malignancies, and MM patients may also benefit from TKI-based treatment strategies. In this review, we seek to understand the applicability of TKIs used in MM clinical trials in the last 10 years.
A Chemical Investigation of the Antioxidant Capacity of Extracts from Red Macroalga Gracilaria domingensis
Authors: Torres Priscila , Chow Fungyi , dos Santos Deborah Yara Alves Cursino
Published: August 2022

Extracts that were obtained with solvents of increasing polarity (hexane, dichloromethane, methanol, 80% methanol, and water) from the red macroalga Gracilaria domingensis were evaluated by reducing power with ferric reduction antioxidant power (FRAP) and Folin–Ciocalteu (FC) assays, lipid peroxidation inhibition by β-carotene-linoleic acid assay, and metal chelating ability based on the iron-ferrozine system. The highest antioxidant capacity was reported for the hexane (Hx) extract by the FRAP, metal chelating, and lipid peroxidation inhibition assays. An activity-guided fractionation of the Hx extract was carried out for the identification of its active constituents. The primary components were the most active antioxidant compounds. Despite the high antioxidant activities, the Hx extract was not active in the FC assay. In this assay, the activities were found in the methanol (M) and 80% methanol (80M) extracts. The FC assay is commonly used to measure the total phenolic compounds. However, no phenolic compounds were detected by GC-MS and HPLC analyses in the M and 80M extracts. Thus, non-phenolic components influenced the FC assay. The M and 80M extracts showed high content of mycosporine-like amino acids (MAAs). A fraction contained two MAAs (porphyra-334 and shinorine) (156 mg GAE·g−1) showed a similar performance to the values that were found for well-known antioxidants (BHT = 156 mg GAE·g−1 and Trolox = 166 mg GAE·g−1) and 30 times higher than those of the original extracts (~5 mg GAE·g−1) in the FC assay. Thus, MAAs contribute to the antioxidant activities that were observed in the FC assay within the studied samples. Together, these results advance our understanding of the antioxidant properties of algal extracts.
Selective Electroless Copper Plating of Ink-Jet Printed Textiles Using a Copper-Silver Nanoparticle Catalyst
Authors: Azar Golnaz Taghavi Pourian , Danilova Sofya , Krishnan Latha , Fedutik Yirij , Cobley Andrew J.
Published: August 2022

The electroless copper plating of textiles, which have been previously printed with a catalyst, is a promising method to selectively metallise them to produce high-reliability e-textiles, sensors and wearable electronics with wide-ranging applications in high-value sectors such as healthcare, sport, and the military. In this study, polyester textiles were ink-jet printed using differing numbers of printing cycles and printing directions with a functionalised copper–silver nanoparticle catalyst, followed by electroless copper plating. The catalyst was characterised using Transmission Electron Microscopy (TEM) and Ultraviolet/Visible (UV/Vis) spectroscopy. The electroless copper coatings were characterised by copper mass gain, visual appearance and electrical resistance in addition to their morphology and the plating coverage of the fibres using Scanning Electron Microscopy (SEM). Stiffness, laundering durability and colour fastness of the textiles were also analysed using a stiffness tester and Launder Ometer, respectively. The results indicated that in order to provide a metallised pattern with the desired conductivity, stiffness and laundering durability for e-textiles, the printing design, printing direction and the number of printing cycles of the catalyst should be carefully optimised considering the textile’s structure. Achieving a highly conductive complete copper coating, together with an almost identical and sufficiently low stiffness on both sides of the textile can be considered as useful indicators to judge the suitability of the process.
Porous Silicon Oxycarbonitride Ceramics with Palladium and Pd2Si Nanoparticles for Dry Reforming of Methane
Authors: Wang Jun , Grünbacher Matthias , Penner Simon , Bekheet Maged F. , Gurlo Aleksander
Published: August 2022

Pd-containing precursor has been synthesized from palladium acetate and poly(vinly)silazane (Durazane 1800) in an ice bath under an argon atmosphere. The results of ATR-FTIR and NMR characterizations reveal the chemical reaction between palladium acetate and vinyl groups in poly(vinyl)silazane and the hydrolyzation reaction between –Si–H and –Si–CH=CH2 groups in poly(vinyl)silazane. The palladium nanoparticles are in situ formed in the synthesized precursors as confirmed by XRD, XPS, and TEM. Pd- and Pd2Si-containing SiOCN ceramic nanocomposites are obtained by pyrolysis of the synthesized precursors at 700 °C, 900 °C–1100 °C in an argon atmosphere. The pyrolyzed nanocomposites display good catalytic activity towards the dry reforming of methane. The sample pyrolyzed at 700 °C possesses the best catalytic performance, which can be attributed to the in situ formed palladium nanoparticles and high BET surface area of about 233 m2 g−1.
Emulsion Polymerization Using an Amphiphilic Oligoether Ionic Liquid as a Surfactant
Authors: Jiménez-Victoria Ariadna , Peralta-Rodríguez René D. , Saldívar-Guerra Enrique , Cortez-Mazatán Gladis Y. , Soriano-Melgar Lluvia de Abril A. , Guerrero-Sánchez Carlos
Published: August 2022

We investigate the use of an ionic liquid (IL) as a surfactant in emulsion polymerization (EP) reactions. ILs have been proposed as surfactants for micellar dispersions, emulsions, micro-emulsions and suspensions. Thus, it is important to acquire knowledge of the application of ILs in heterogeneous polymerizations. We selected the amphiphile cationic oligoether IoLiLyte C1EG™ as an IL for this purpose and compared its performance to that of the conventional surfactant dodecyl trimethyl ammonium bromide (DTAB) in the EP of methyl methacrylate and styrene. After we found the proper concentration range of the IL, this amphiphile showed similar polymerization rates to those observed with DTAB for both monomers. The evolution of monomer conversion and the final average diameter of formed polymeric particles were similar for both evaluated surfactants, demonstrating their capability to stabilize the EPs of the investigated monomers. We simulated the evolution of monomer conversion and particle size using a conventional model for emulsion polymerization, which showed good agreement with the experimental data, suggesting that the EP with this IL follows Smith-Ewart kinetics.
Improvement of the Structure and Physicochemical Properties of Polylactic Acid Films by Addition of Glycero-(9,10-trioxolane)-Trialeate
Authors: Alexeeva Olga , Olkhov Anatoliy , Konstantinova Marina , Podmasterev Vyacheslav , Tretyakov Ilya , Petrova Tuyara , Koryagina Olga , Lomakin Sergey , Siracusa Valentina , Iordanskii Alexey L.
Published: August 2022

Glycero-(9,10-trioxolane)-trioleate (ozonide of oleic acid triglyceride, OTOA) was introduced into polylactic acid (PLA) films in amounts of 5, 10, 30, 50, and 70% w/w. The morphological, mechanical, thermal, and water absorption properties of PLA films after the OTOA addition were studied. The morphological analysis of the films showed that the addition of OTOA increased the diameter of PLA spherulites and, as a consequence, increased the proportion of amorphous regions in PLA films. A study of the thermodynamic properties of PLA films by differential scanning calorimetry (DSC) demonstrated a decrease in the glass transition temperature of the films with an increase in the OTOA content. According to DSC and XRD data, the degree of crystallinity of the PLA films showed a tendency to decrease with an increase in the OTOA content in the films, which could be accounted for the plasticizing effect of OTOA. The PLA film with 10% OTOA content was characterized by good smoothness, hydrophobicity, and optimal mechanical properties. Thus, while maintaining high tensile strength of 21 MPa, PLA film with 10% OTOA showed increased elasticity with 26% relative elongation at break, as compared to the 2.7% relative elongation for pristine PLA material. In addition, DMA method showed that PLA film with 10% OTOA exhibits increased strength characteristics in the dynamic load mode. The resulting film materials based on optimized PLA/OTOA compositions could be used in various packaging and biomedical applications.
Current Progress in Biopolymer-Based Bionanocomposites and Hybrid Materials
Authors: Ilyas R. , Sapuan S. , Bayraktar Emin
Published: August 2022

Current Progress in Biopolymer-Based Bionanocomposites and Hybrid Materials is a newly opened Special Issue of Polymers, which aims to publish original and review papers on the new scientific and applied research and make boundless contributions to the findings and understanding of the reinforcing effects of various synthetic and natural fibres on the performance of biopolymer composites [...]
Experimental Validation of Numerical Model for Thermomechanical Performance of Material Extrusion Additive Manufacturing Process: Effect of Process Parameters
Authors: Al Rashid Ans , Koç Muammer
Published: August 2022

The material extrusion additive manufacturing (MEAM) process for polymers seems straightforward. However, several controlled and uncontrolled factors affect the 3D printed product quality, e.g., MEAM process parameters, thermomechanical properties of the material, and part design. Therefore, it is crucial to understand these interlinked factors of part geometry, material properties, and 3D printing (3DP) process parameters to optimize 3D printed product quality. The numerical models and simulation tools can predict the thermomechanical performance of the MEAM process under given input parameters (material, design, and process variables) and reduce the research and development costs significantly. However, the numerical models and tools need further exploration and validation of simulation predictions for their adaptability and reliability. Therefore, in this study, numerical simulations were performed to observe the impact of process parameters on the part quality of MEAM 3D printed components. The two crucial process parameters (i.e., extrusion temperature and layer resolution) were varied while keeping the other process parameters, part geometry (tensile testing coupon), and material properties (acrylonitrile butadiene styrene (ABS)) constant. These two process parameters were sequentially optimized for optimum part quality, first by varying the extrusion temperature and secondly by changing the printing resolution using the optimum printing temperature. The 3DP process quality was evaluated in terms of dimensional accuracy, distortions, and residual stresses. Finally, the specimens were 3D printed under similar process conditions to validate the numerical model predictions.
Removing InSAR Topography-Dependent Atmospheric Effect Based on Deep Learning
Authors: Chen Chen , Dai Keren , Tang Xiaochuan , Cheng Jianhua , Pirasteh Saied , Wu Mingtang , Shi Xianlin , Zhou Hao , Li Zhenhong
Published: August 2022

Atmospheric effects are among the primary error sources affecting the accuracy of interferometric synthetic aperture radar (InSAR). The topography-dependent atmospheric effect is particularly noteworthy in reservoir areas for landslide monitoring utilizing InSAR, which must be effectively corrected to complete the InSAR high-accuracy measurement. This paper proposed a topography-dependent atmospheric correction method based on the Multi-Layer Perceptron (MLP) neural network model combined with topography and spatial data information. We used this proposed approach for the atmospheric correction of the interferometric pairs of Sentinel-1 images in the Baihetan dam. We contrasted the outcomes with those obtained using the generic atmospheric correction online service for InSAR (GACOS) correction and the traditional linear model correction. The results indicated that the MLP neural network model correction reduced the phase standard deviation of the Sentinel-1 interferogram by an average of 64% and nearly eliminated the phase-elevation correlation. Both comparisons outperformed the GACOS correction and the linear model correction. Through two real-world examples, we demonstrated how slopes with displacements, which were previously obscured by a significant topography-dependent atmospheric delay, could be successfully and clearly identified in the interferograms following the correction by the MLP neural network. The topography-dependent atmosphere can be better corrected using the MLP neural network model suggested in this paper. Unlike the previous model, this proposed approach could be adjusted to fit each interferogram, regardless of how much of the topography-dependent atmosphere was present. In order to improve the effectiveness of DInSAR and time-series InSAR solutions, it can be applied immediately to the interferogram to retrieve the effective displacement information that cannot be identified before the correction.
Scalable Crop Yield Prediction with Sentinel-2 Time Series and Temporal Convolutional Network
Authors: Yli-Heikkilä Maria , Wittke Samantha , Luotamo Markku , Puttonen Eetu , Sulkava Mi , Pellikka Petri , Heiskanen Janne , Klami Arto
Published: August 2022

One of the precepts of food security is the proper functioning of the global food markets. This calls for open and timely intelligence on crop production on an agroclimatically meaningful territorial scale. We propose an operationally suitable method for large-scale in-season crop yield estimations from a satellite image time series (SITS) for statistical production. As an object-based method, it is spatially scalable from parcel to regional scale, making it useful for prediction tasks in which the reference data are available only at a coarser level, such as counties. We show that deep learning-based temporal convolutional network (TCN) outperforms the classical machine learning method random forests and produces more accurate results overall than published national crop forecasts. Our novel contribution is to show that mean-aggregated regional predictions with histogram-based features calculated from farm-level observations perform better than other tested approaches. In addition, TCN is robust to the presence of cloudy pixels, suggesting TCN can learn cloud masking from the data. The temporal compositing of information do not improve prediction performance. This indicates that with end-to-end learning less preprocessing in SITS tasks seems viable.
Scattered Ultrasonic Guided Waves Characterized by Wave Damage Interaction Coefficients: Numerical and Experimental Investigations
Authors: Humer Christoph , Höll Simon , Kralovec Christoph , Schagerl Martin
Published: August 2022

The present paper comprehensively investigates the complex interaction between ultrasonic guided waves and local structural discontinuities, such as damages, through highly sensitive features: so-called wave damage interaction coefficients (WDICs). These WDICs are unique for each structural discontinuity and depend solely on their characteristics for a given structure and condition. Thus, they can be particularly useful for advanced assessment of lightweight structures in the context of non-destructive evaluation and structural health monitoring. However, the practical application of WDICs entails significant difficulties due to their sensitivity and complex patterns. Therefore, this study attempts to guide researchers and practitioners in the estimation of WDICs from numerical simulations and physical experiments. Detailed investigations are made for an aluminum host plate modified by artificial structural discontinuities, i.e., surface-bonded steel sheets. The numerical simulations are performed to predict WDICs and study sensitivities using a sophisticated finite element model. The experimental setup uses piezoelectric transducers to excite guided waves in the host plate. A single scanning laser Doppler vibrometer measures the scattered guided waves caused by the surface-bonded steel sheets, and the resulting WDICs with possible influences are investigated. In both cases, the orientation and thickness of the attached steel sheets were varied to create 12 different damage scenarios. In general, the comparison between numerical and experimental WDICs show good agreement. This underpins the applicability of the general methodology for simulating and measuring WDICs over all scenarios. Furthermore, the WDIC scattering patterns reveal a clear dependency of the peaks in the back-scattered reflections for both the numerical and experimental amplitude coefficients on the damage orientation, basically following the law of reflection. However, some discrepancies between both studies were observed. Numerical sensitivity analysis identified the adhesive layer as one reason for such differences. Additionally, misalignment errors in the experimental measurements were also found to affect WDICs. Therefore, an improved baseline subtraction method is proposed, which clearly enhances the experimental WDICs. Finally, an experimental sensitivity study of WDICs for selected sensing radii revealed only a minor influence. All these investigations were made for the amplitude as well as the phase representation of WDICs. Thus, these findings may open the way to future research and development of techniques employing WDICs for advanced applications of non-destructive evaluation and structural health monitoring.
The main trends in modern musical art
Authors:   Moscow University for the Humanities, Shcheglova Tatyana Gennadievna
Published: August 2022

The article discusses a new stage in the development of modern musical culture, which manifested itself in the postmodern era. These qualities are manifested in the formation of a new sound, the integration of musical art with other types of art, the mixing of musical styles, the emergence of borderline forms of musical art, and the birth of a modern musical language. In the article, art is correlated with the processes of scientific and technological progress.