bluuebunny/crossref_metadata_2025 huggingface dataset:
Tipos de relações conjugais, papéis de gênero e diferenciais socioeconômicos no Brasil
Authors: Gandra Juliana Mara F. Viana , Wajnman Simone , Luz Luciana
Published: January 2025

A mudança nos padrões familiares observada a partir da segunda metade do século XX leva à necessidade de se examinar a estrutura familiar muito além dos contornos típicos de tamanho e composição. As transformações culturais, institucionais e valorativas da sociedade, com seus efeitos na formação e dissolução das famílias, mostram que a formação e o arranjo doméstico dos casais se afastam, cada vez mais, do tradicional modelo de especialização de gênero (male breadwinner/female homemaker). Tratando destas mudanças para o Brasil, este trabalho discute as inter-relações entre simetria de papéis de gênero, os tipos conjugais e a organização doméstica entre os cônjuges/companheiros. Utilizando dados da PNAD 2014, os casais brasileiros foram classificados em uma escala de tradicionalismo de papéis de gênero, em uma aplicação metodológica de análise de perfis latentes. As evidências encontradas mostram que a maioria dos casais do país ainda se organiza em uma divisão tradicional de responsabilidades (42,4%). Quase 39% dos casais reúnem características da chamada “revolução de gênero estagnada”: as mulheres dividem a responsabilidade de provimento de renda com seus parceiros, mas eles não dividem com elas as responsabilidades domésticas. Somente uma pequena parcela de casais, com elevada escolaridade e alta renda, parece usufruir de uma divisão em que ambos compartilham igualmente as responsabilidades domésticas (12,6%). Uma análise da associação entre os tipos conjugais, a formação familiar e comportamentos igualitários de gênero é realizada por meio de uma regressão logística multinomial, em que a variável dependente é a classe que representa a posição do casal na escala de tradicionalismo de papéis de gênero. Os resultados sugerem que parcerias mais igualitárias podem ser uma realidade mais alcançável por mulheres formalmente casadas e com educação de nível superior.
Kualitas Hidup Pasien Kanker Kolorektal dengan Stoma Temporer di RSUD Dr. Moewardi Surakarta
Authors: Wahyudya Setya Ananta  , Ida Bagus Budhi Surya Adnyana  , Senyum Indrakila
Published: January 2025

Pendahuluan: Kanker kolorektal adalah suatu tumor maligna yang muncul dari jaringan epitel dari kolon atau rektum. Kualitas hidup adalah suatu istilah yang membatasi suatu keburukan dan lebih menekankan pada komponen kebahagiaan dan kepuasan dalam hidup. Penelitian ini dilakukan untuk melihat gambaran kualitas hidup pasien kanker kolorektal dengan stoma temporer yang memuat transformasi fisik, psikososial, dan kecemasan terhadap citra tubuh pasien.
Metode: Penelitian ini adalah penelitian analitik observasional dengan pendekatan cross sectional. Penentuan jumlah sampel menggunakan teknik simple random sampling dan ditemukan jumlah sampel sebanyak 22 pasien. Kualitas hidup pasien akan diukur menggunakan kueisoner EORTC QLQ CR-29 yang telah divalidasi dan diisi langsung oleh pasien dengan panduan peneliti. Data yang dikumpulkan diperiksa,dan diolah dengan bantuan program komputer, dianalisis dengan analisis sederhana dan disajikan dalam bentuk tabel dengan kategori baik, cukup, dan kurang.
Hasil: Didapatkan hasil dari 22 sampel, 21 diantaranya menunjukan kualitas hidup baik dan 1 sampel dengan kualitas hidup cukup.
Kesimpulan: Ditemukan gambaran kualitas hidup yang baik pada pasien kanker kolorektal dengan stoma temporer di RSUD dr. Moewardi Surakarta.
Perbandingan Kadar Hemoglobin dan Hematokrit pada Early Onset dan Late Onset Preeclampsia di RSUD Dr. Moewardi Surakarta
Authors: Annisa Rizki Savitri  , Wisnu Prabowo  , Eric Edwin Yuliantara
Published: January 2025

Pendahuluan: Preeklampsia merupakan salah satu penyebab tingginya angka kematian ibu, terutama di negara berkembang. Pemeriksaan hematokrit dan hemoglobin adalah salah satu pemeriksaan yang mudah dilakukan di hampir semua fasilitas kesehatan. Banyak penelitian menunjukkan bahwa early onset preeclampsia (EO-PE) dikaitkan dengan kondisi kehamilan yang lebih buruk dibandingkan late onset preeclampsia (LO-PE). Penelitian ini bertujuan untuk mengetahui perbandingan hematokrit dan hemoglobin pada early onset dan late onset preeclampsia sehingga diharapkan dapat menjadi sarana deteksi dini sederhana dan mudah dilakukan, serta berpotensi untuk dikembangkan.
Metode: Penelitian ini merupakan studi cross sectional dengan metode analisis uji T Independen dan regresi logistik. Sampel diambil dari data sekunder berupa rekam medis di RSUD Dr. Moewardi sejak Januari 2021 — Mei 2023.
Hasil: Sampel yang memenuhi kriteria didapatkan 50 wanita dengan EO-PE dan 50 wanita dengan LO-PE. Hasil penelitian ini didapatkan nilai rerata hemoglobin pada EO-PE yaitu 12,852g/dL dan pada LO-PE 11,030 g/dL, dengan perbandingan rerata yang signifikan (p-value 0,000). Sedangkan pada hematokrit didapatkan nilai rerata pada EO-PE yaitu 37,138% dan pada LO-PE didapatkan mean 32,148% dan hasil perbandingan reratanya signifikan (p-value 0,000). Perbandingan hubungan hemoglobin dan hematokrit terhadap onset preeklampsia didapatkan hemoglobin (OR  2,003) lebih berhubungan dengan EO-PE dibandingkan hematokrit  (OR 1,219).
Kesimpulan: Mean hemoglobin serta hematokrit pada early onset preeclampsia lebih tinggi secara signifikan dibandingkan  dengan late onset preeclampsia. Hemoglobin lebih berhubungan dengan  early onset preeclampsia dibandingkan hematokrit.
LOWERING CHOLESTEROL WITH HIIT: AN EFFECTIVE SOLUTION FOR OVERWEIGHT WOMEN
Authors: Vigriawan Gosy Endra , Raharjo Slamet , Andiana Olivia , Yunus Mahmud , Pribadi Heri Purnama , Abdullah Ahmad , Sugiarto Dinta , Yuniarto Andryas , Kusuma Bakti Fajar Raya Ferdinal , Ayubi Novadri , Airlangga Daulay Dio Alif
Published: January 2025

A sedentary lifestyle is a major risk factor for cardiovascular disease, especially in women who are overweight. High-Intensity Interval Training (HIIT) has been known as an effective exercise method in improving cardiometabolic health. This study aims to analyze the effect of HIIT on total cholesterol levels in overweight women with a sedentary lifestyle. The research method used an experimental design with two groups, namely the treatment group that underwent a HIIT program for several weeks and the control group that did not undergo exercise. The results showed that there was a significant difference in changes in total cholesterol levels between the treatment group and the control group, where the group that did HIIT experienced a greater decrease in cholesterol levels. These findings support that HIIT has the potential to be an effective intervention to lower total cholesterol levels in populations at risk of cardiovascular disorders. HIIT can be a practical and efficient alternative for individuals with limited time to manage their heart and metabolic health.
SURVEY OF PHYSICAL FITNESS LEVELS OF CLASS V AND VI STUDENTS OF JATIBATUR I STATE PRIMARY SCHOOL
Authors: Kurniawan Kukuh Yusuf
Published: January 2025

This research was motivated by the absence of data on the level of physical fitness of students at SD Negeri Jatibatur 1, Gemolong District, Sragen Regency. So this research aims to determine the level of physical fitness of students at SD Negeri Jatibatur 1, Gemolong District, Sragen Regency. The subjects in this research were 28 students in grades V and VI, consisting of 14 male students and 14 female students. The research method used in this research is a test survey method, using the Indonesian physical fitness test instrument. The Indonesian physical fitness test (TKJI) includes a 40 meter sprint, hanging bent elbows, lying down for 30 seconds, jumping upright and a long run of 600 meters. The data analysis technique in this research uses standard physical fitness norms from TKJI to measure students' physical fitness levels. The results of this study obtained a classification for the level of physical fitness of students class V and VI, most of which were in the medium category, 14 children (50%), the poor category, 9 children (32.1%), the good category, 4 children (14.3%), the 1 child (3.6%) is very poor, and 0 children (0%) are in the very good category. The conclusion of this research is that the level of physical fitness in class V and VI students at SD Negeri Jatibatur 1, Gemolong District, Sragen Regency is in the medium category. The researcher's suggestions for physical education teachers and schools are to improve and implement programs oriented towards fostering and improving students' physical fitness.
EL MERCADO DE TRABAJO Y LA POBREZA EN COLOMBIA
Authors: Nel Páez Pedro , Jiménez William Guillermo
Published: January 2025

El mercado laboral colombiano siempre será cuestionado por diferentes razones. A pesar de flexibilizarse continuamente con varias reformas laborales, hay grupos que demandan aún más flexibilización. Cuestionan los pagos del salario mínimo y la seguridad social, aun cuando la flexibilización es la causa de la precariedad laboral generalizada y el aumento del trabajo informal. El objetivo de este artículo es múltiple: primero, muestra que la visión del mercado laboral prevaleciente se adscribe a la corriente dominante en la economía; segundo, señala que el objetivo de una mayor flexibilización son los trabajadores formales que aún persisten en la economía; tercero, se demuestra que un hogar de tres miembros con solo un perceptor de renta que sea formalizado y gane un salario mínimo, deja por debajo de la línea de pobreza a todos los miembros de ese hogar. Es un estudio explicativo, correlacional y comparativo que combina el método cualitativo y cuantitativo. La información fue obtenida mediante la técnica de la revisión documental sobre fuentes secundarias; para ello, se compararon los salarios mínimos promedio de China con los de Colombia, encontrando que no hay una relación entre el crecimiento y el aumento de los salarios, y que cuando una economía se desarrolla, los salarios se mueven en la misma dirección. Se concluye que: a) el objetivo de las reformas laborales son los trabajadores que aúngozan de algún grado de formalidad; b) cualquier política de empleo encaminada a flexibilizar aún más el mercado de trabajo, está enfocada a modificar las condiciones de trabajo de las personas ocupadas que devengan un salario mínimo o más, menoscabando el ingreso y precarizando el trabajo; c) a los ocupados informales ya no se les puede desmejorar más sus condiciones de trabajo.
Plan de negocio para la implementación de una planta purificadora de agua en Lurigancho-Chosica
Authors:   , Valverde Rojas Jeanette Milagros , Dominguez Garcia Mariella , Gutierrez Delgado Rosa Beatriz , Javier Ramos Ruben Carlos
Published: January 2025

Aguas White Vida S.A.C. se establecerá como una empresa sólida e innovadora en el mercado de producción y distribución de agua purificada en la zona de Lurigancho-Chosica (Lima). Con una amplia experiencia en el sector, nuestra compañía se destacará por ser un referente en términos de calidad y confiabilidad, gracias a nuestra marca insignia, PurAgua. Nuestra planta de producción contará con tecnología de filtración y purificación de última generación, lo que nos permitirá obtener un producto final de excelentes propiedades y libre de contaminantes; este riguroso proceso de purificación pasará por estrictos controles de calidad, asegurándonos que PurAgua cumpla con los más altos estándares de inocuidad y salubridad. Asimismo, la estrategia de comercialización de PurAgua abarcará diversos canales de distribución local, incluyendo puntos de venta minoristas, mayoristas, plataformas de e-commerce; gracias a las alianzas estratégicas con proveedores y socios comerciales, la marca gozará de una amplia cobertura y disponibilidad en los principales establecimientos de la zona de Lurigancho-Chosica. Comprometidos con el desarrollo sostenible, Aguas White Vida S.A.C. implementará prácticas de producción respetuosas con el ambiente, promoviendo el reciclaje y reutilización de envases, así como la concientización entre sus clientes sobre la importancia del consumo responsable de agua. Nuestro equipo, estará conformado por profesionales altamente capacitados en las áreas de Producción, Logística, Comercialización y Administración; esta sólida estructura organizacional, aunada a una visión estratégica a largo plazo, nos permitirá consolidar a PurAgua como una marca líder en el mercado local.
Producción de biogás y abono líquido mediante la digestión anaeróbica del exudado de cacao
Authors:   , Gutierrez Espantoso Raul Andre
Published: January 2025

En la actualidad, los combustibles fósiles representan la fuente principal de energía, sin embargo, su inadecuada gestión provoca emisiones contribuyentes al cambio climático y al calentamiento global. El proceso de digestión anaeróbica viene demostrando ser es una alternativa capaz de proporcionar un gran potencial energético (generando biogás y biol), argumentando su viabilidad, tanto energética como medioambiental; y a su vez, brindando un manejo eficiente de residuos orgánicos. Esta investigación se llevó a cabo en Neshuya, Perú y tuvo como objetivos medir la cantidad de biogás y evaluar la calidad de biol, obtenidos a partir de la digestión anaeróbica de la mezcla de exudado de cacao, estiércol de vaca y cal. El experimento constó de 3 tratamientos (T1, T2 y T3) y 1 control (C), donde C presentó 65L de exudado de cacao, T1, 56L de exudado de cacao y 8kg de estiércol de vaca, T2, 47L de exudado de cacao y 16kg de estiércol de vaca y, T3, 38L de exudado de cacao y 24kg de estiércol de vaca. Para ello, se construyeron biodigestores de tipo Batch, donde se llevaron a cabo los procesos de digestión anaeróbica durante 70 días. Los resultados obtenidos demostraron mayor producción de biogás y una mejor composición del biol según el siguiente orden descendente T3>T2>T1>Control, siendo el T3 el que obtuvo resultados más elevados y óptimos.
MIP-3α-antigen fusion DNA vaccine enhances sex differences in tuberculosis model and alters dendritic cell activity early post vaccination
Authors: Gordy James T. , Bates Rowan E. , Glass Elizabeth , Meza Jacob , Li Yangchen , Schill Courtney , Taylor Alannah D. , Wang Tianyin , Chen Fengyixin , Plunkett Khaleel , Karanika Styliani , Karakousis Petros C. , Markham Richard B.
Published: January 2025

Background
Tuberculosis (TB) remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the infection. Bacterial persistence during exposure to bactericidal antibiotics is at least partially mediated by the bacterial stringent response enzyme, RelMtb. A therapeutic DNA vaccine targeting RelMtb has been shown to increase the efficacy of antitubercular drugs, and fusing macrophage-inflammatory protein 3α (MIP-3α), which interacts with CCR6 on immature dendritic cells (iDCs), to RelMtb further increases the vaccine’s therapeutic efficacy. A secondary analysis of these prior studies elucidated prominent sex-based differences in vaccine therapeutic efficacy, with female mice showing improved microbial outcomes compared to males as a result of the Rel and MIP-3α-Rel vaccine constructs, with a greater sex-associated difference in the MIP-3α-Rel group. In the current study, we addressed the hypothesis that these sex-related differences are due to differential DC activation/function soon after vaccination.
Methods
A EαGFP reporter vaccine model was used to track vaccine antigen presentation by an antibody Y-Ae which binds the Eα peptide tag in complex with I-Ab MHC-II molecules.
Results
MIP-3α-EαGFP groups had more DCs presenting vaccine antigen infiltrating from the periphery, with more abundant Langerhans cells in males and greater CD8 + CD103 + cross-presenting dermal DCs in females. This model also shows there is greater DC activation, as measured by CD80 and MHC II MFI, by MIP-3α compared to EαGFP alone, especially in female mice.
Conclusions
Our findings are consistent with the sex- and MIP-3α-related differences seen in the therapeutic model and supports the hypothesis that in both sexes MIP-3α enhances vaccine uptake and cell activation by peripheral iDCs. Additionally, Female mice showed greater levels of antigen presentation, especially in DCs able to cross-present antigen, explaining why they had the best outcomes. Further studies are required to understand underlying mechanisms and to link APC results directly to T-cell responses.
Where and when will the next record-breaking precipitation disaster occur?
Authors: de Vries Iris , Schillinger Maybritt , Fischer Erich , Sippel Sebastian , Knutti Reto
Published: January 2025

Climate change increases the frequency and intensity of extreme precipitation over most of the global land, and flood impacts associated with extreme precipitation lead to major damage to society, economy, and ecosystems. Record-high precipitation events are particularly relevant for impacts since they are by definition more severe than any historical event, and can thus lead to unforeseeable damage. Both the probability of breaking local records in our real climate as well as the preparedness of local society for record-high events is dependent on the observed extreme event history.

Here, we estimate local extreme precipitation disaster potential, the potential for record-high precipitation to occur and cause a high-impact disaster, conditional on historical observations. Based on two observational datasets and reanalysis, we find that natural variability strongly shapes the global pattern of future conditional record breaking probabilities, highlighting that any region can be subject to high disaster potential if its current record value happens to be low. Climate change modifies this pattern in a non-linear manner: while climate change according to the SSP2-4.5 scenario increases the average probability of breaking a record by 2050 about 1.4 times, high (more rare) current records are much more sensitive to climate change, featuring an up to 2.5 times increase in record breaking probabilities by 2050. In other words: regions with low current records are most at risk, but for regions with high current records climate change increases the risk at the highest rate.

Disaster potential is further increased by low preparedness related to disaster memory: the longer ago the last record-breaking event, the more likely that local society is unaware of and underprepared for the risk. High disaster potential regions are dispersed globally but hotspots appear in Australia and in particularly vulnerable regions in the tropics and South-East Asia.
Vulnerability and exposure in many of these regions is high due to poverty and rapid urbanisation, associated with adaptation gaps, resulting in a major, imminent threat.
Structural Features of Pathogenic Aggregates Correlate with Cell Pathology in Differentiated Cells
Authors: Raz Vered , Mallon Sander , Bos Erik , Sheikhhassani Vahid , Shademan Milad , Voortman Lennard , Mashaghi Alireza , Sharp Thom
Published: January 2025

The accumulation of intracellular protein aggregates is a hallmark of aging. In hereditary adult-onset neuromuscular diseases (NMDs), these aggregates are not only characteristic but also pathogenic, marking age-related neuromuscular disorders. The transition from age-associated non-pathogenic aggregates to disease-driving pathogenic aggregates remains poorly understood. Poly(A) binding protein nuclear 1 (PABPN1) forms non-pathogenic nuclear aggregates in post-mitotic aged cells. However, a short trinucleotide expansion in PABPN1 leads to muscle dysfunction in Oculopharyngeal Muscular Dystrophy (OPMD), where insoluble nuclear aggregates in skeletal muscle become a defining disease feature. Combining an array of advanced imaging modalities, we examined the morphological differences between nuclear aggregates formed by non-pathogenic and pathogenic PABPN1 variants. Through micro- to nanoscale analyses, we identified key structural differences in the aggregation propensity of these variants in both differentiated and undifferentiated muscle cells and linked these differences to mRNA cellular dysfunctions. Our findings provide new insights into the structural distinctions between pathogenic and non-pathogenic aggregates and their implications for cellular dysfunction in neuromuscular diseases.
Integrating Genomic Data with Deep Learning for Personalized Cancer Treatment
Authors: Shukla Tanmay
Published: January 2025

Cancer remains a significant global health burden, with its heterogeneous genetic and molecular etiology complicating effective treatment. Precision medicine introduces a transformative paradigm by leveraging patients’ genomic profiles to improve individualized treatment response predictions and optimize therapeutic strategies. Integrating genomic data with deep learning (DL) has emerged as a promising approach to advancing personalized cancer care. DL’s capacity to process high-dimensional datasets, uncover intricate patterns, and predict actionable outcomes makes it a potent tool in oncology. This review explores DL’s applications in genomic data analysis for cancer treatment, focusing on biomarker discovery, drug response prediction, and multi-omics integration. Challenges, including data heterogeneity, interpretability, and ethical considerations, are critically examined. A proposed framework for integrating multi-modal data highlights its potential to enhance clinical decision-making. This study underscores the significant promise of DL in reshaping cancer treatment paradigms, emphasizing the importance of robust validation in real-world settings.
Efficacy of FLT3 Inhibitors in Patients with FLT3-Mutated Acute Myeloid Leukemia Unfit for Intensive Chemotherapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Fero Henri , Faccin Ester , Mera Erilda , Trako Kristi , Gjika Frenki , Joshi Dhruvi , Alabbas Fahad
Published: January 2025

Introduction:
FLT3 inhibitors have demonstrated increased efficacy in patients with FLT3-mutated acute myeloid leukemia (AML). However, their effects on patients unfit for intensive chemotherapy remain undefined. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of FLT3 inhibitors in AML patients unfit for intensive chemotherapy.
Methods:
A systematic search was conducted between October 2024 and December 2024 across PubMed, Embase, and Cochrane Central. Studies included patients with AML who were unfit for intensive chemotherapy, treated with FLT3 inhibitors as monotherapy or in combination with low-intensity regimens, compared to standard low-intensity chemotherapy regimens. The primary outcome was the OS, defined as the proportion of patients alive at a specified time after treatment initiation or diagnosis. Statistical analysis was performed under a random effects model using Review Manager 8.11.0. Heterogeneity was assessed using I² statistics.
Results:
745 patients from six randomized controlled trials (RCTs) were included. FLT3 inhibitors were used in 421 (56.51%) AML patients unfit for intensive chemotherapy. Among the six studies, one reported quizartinib combined with low-dose cytarabine, two reported gilteritinib monotherapy, one reported gilteritinib with azacitidine, one reported quizartinib monotherapy, and one reported decitabine with midostaurin. Follow-up ranged from 6.5 to 48 months.
FLT3 inhibitors significantly improved OS (HR 0.52; 95% CI 0.35–0.78, P = 0.001; I² = 51%) compared to standard chemotherapy. However, the risk of grade ≥3 adverse events (RR 1.42; 95% CI 1.03–1.96, P = 0.03; I² = 0%) and QT interval prolongation (RR 3.49; 95% CI 1.43–8.51, P = 0.006; I² = 0%) was significantly higher in the FLT3 inhibitors group.
Conclusion:
FLT3 inhibitors, used either as monotherapy or in combination with low-intensity chemotherapy, improve OS in FLT3-mutated AML patients unfit for intensive chemotherapy. However, the increased risk of grade ≥3 adverse events and QT interval prolongation warrants careful monitoring in clinical practice.
Evidence of Anlotinib as First- or Second-line Monotherapy for Advanced Hepatocellular Carcinoma and Clinical Role of α-fetoprotein: a Multicenter Retrospective Study in China
Authors: Yin Yanjiang , Xu Bowen , Chang Jianping , Li Zhiyu , Bi Xinyu , Wei Zhicheng , Che Xu , Cai Jianqiang
Published: January 2025

Background Anlotinib, a novel multi-targeting tyrosine kinase inhibitor (TKI), has been investigated in a variety of malignant tumors. This retrospective study was designed to investigate the efficacy and safety of anlotinib as first- or second-line therapy for advanced or metastatic hepatocellular carcinoma (HCC), and to identify early predictors for disease control.Methods This multicenter retrospective study included 158 patients with advanced HCC. 54 patients received anlotinib and 104 patients received sorafenib. Progression-free survival (PFS), overall survival (OS), and treatment response were compared. Subgroup analyses and biomarker evaluations were also conducted.Results The anlotinib group demonstrated significantly longer OS (16.0 months) compared to sorafenib (14.0 months; HR: 1.779; P = 0.002), while PFS was similar (5.0 vs.4.0 months; HR: 1.217; P = 0.251). Drug-related adverse effects were comparable between groups, with no new safety concerns. Subgroup analyses revealed significant benefits of anlotinib in patients with baseline AFP ≥ 400 ng/mL and in HBV-positive individuals. As for anlotinib group, AFP reduction of ≥ 25% at 4 weeks post-treatment was an independent predictor of disease control (P = 0.001).Conclusion Anlotinib showed promising efficacy and tolerability in Chinese patients. AFP response was an early predictor of disease control in patients with anlotinib treatment.
Assessing the Clinical Outcomes of a Novel Edof Intraocular Lens: a Functional Classification Approach
Authors: Győry József F. , Németh Gábor , Pesztenlehrer Norbert
Published: January 2025

Background Functional assessment can help identify the true extended depth of focus intraocular lenses (EDOF IOLs) on the market. This study aimed to demonstrate the eligibility of the 877PEY ELON IOL (Medicontur Medical Engineering) as a suitable model for this category and to assess its efficacy in clinical settings.Methods In total, 38 patients (76 eyes) were enrolled in the study with bilateral implantation of the investigational IOL. For functional classification, a distance-corrected monocular defocus curve was taken 3 months postoperatively. At the 3- and 12-month follow-ups, manifest refraction, monocular and binocular distance, intermediate and near visual acuities, contrast sensitivity, and patient-reported outcomes were recorded.Results The defocus range (visual acuity [VA] ≤ 0.2 logMAR) on the distance-corrected monocular normalized defocus curve taken at 3 months was 1.7 D, which falls into the Partial Range of Field Extend (later referred to as PRoF-Ex) category, confirming expectations. The binocular depth of focus (VA ≤ 0.1 logMAR) spanned approximately 0.50 D to -1.50 D, and the functional visual acuity (VA ≤ 0.3 logMAR) spanned approximately 1.00 D to -2.50 D. Monocular CSV-1000 outcomes were above the population normal ranges. 90.9% of the patients were within ± 0.50 D, and 97.7% were within ± 1.00 D SEQ from the target refraction at the 3-month follow-ups. The outcomes of the VFQ-25 questionnaire demonstrated high scores, and the level of spectacle independence, similar to visual acuity, reflected a strong efficacy in distance and intermediate correction with functional near vision. In terms of photopic phenomena, 90% and 87.5% of patients experienced no-to-moderate rates of glare and halos, respectively. The posterior capsular opacification (PCO) rate was 7.89% at the 12-month follow-up. No adverse events were considered serious.Conclusions The 877PEY model demonstrated capability as a PRoF-Ex IOL with remarkable performance. It is safe to use and delivers a high degree of patient satisfaction.
Asymmetry Is the Norm in “Cloverleaf” Aortic Root Structure
Authors: Zhang Honghai , Bello Rodrigo Moreira , Chivukula Venkat Keshav , Ramchandra Abhay B. , Vigmostad Sara , Conway Johnathan , Wahle Andreas , Sonka Milan , Singhal Arun K.
Published: January 2025

Purpose
Except for the aortic root (AoR), the thoracic aorta is a radially symmetric structure. It has recently been described as a three-cloverleaf (sinus) structure, with evidence supporting sinus asymmetry. Due to asymmetry, it is difficult to measure. These measurements are central to clinical evaluation of AoR health. (1) Demonstrate correlation between manually interpreted and machine-assisted (MA) measurements of AoR anatomy. (2) Demonstrate that asymmetry is a consistent characteristic in normal AoRs.
Methods
Our study employed randomly selected, EKG-gated CT scans which had previously been interpreted to be free of thoracic disease. All AoRs were analyzed independently by a thoracic radiologist (RBM) and through MA interpretation (HZ). In addition to one dimensional (1D, as radius) and 2D (area) manual and MA interpretations, 3D measurements (volume and height) of the AoR were made using MA method.
Results
1D and 2D analyses showed high correlations between manual and MA measurements. Asymmetry was apparent in 1D, 2D and 3D measurements between sinuses. 3D measurements demonstrated the strongest pattern of asymmetry, with the average volumes in the noncoronary sinus > right sinus > left sinus as 4660 > 3500 > 2700 mm3 (p < 0.01).
Conclusion
Manual and MA interpretations of AoR dimensions are highly correlative. Although asymmetry exists in all measurements of normal subjects, it is not strong in 1D or 2D measurements. The 3D volume of the noncoronary sinus is larger than the right coronary sinus, which is significantly larger than the left coronary sinus, indicating the importance of 3D measurements.
The biogenetic decision-making processes and perceived utility of genetic counseling amongst LGBTQ couples considering assisted reproductive technology
Authors: Bunkelman Brady , Slamon Jill , Spencer Sara , Allen Samuel H. , Hornberger Katherine , Propst Lauren
Published: January 2025

Assisted reproductive technology (ART) is becoming a more common way for LGBTQ + couples to pursue parenthood. While prior research has focused on their experiences throughout and after ART, we lack understanding of their journey and decision-making preceding conception. This study aimed to determine the role biogenetic information plays in real-time decision-making processes for LGBTQ + couples planning to have children through ART. Additionally, genetic counselors (GCs) are healthcare professionals who specialize in biogenetic decision-making. Little research has been done on LGBTQ + couples’ desire to consult with a GC prior to the ART process. This study sought to establish how LGBTQ + couples perceive the utility of GCs in supporting them through the earlier points of ART. Finally, these decisions do not occur in a vacuum separate from the many barriers LGBTQ + people face, such as legal, financial, social, and more. We therefore also explored how these barriers interacted with their decision-making. This qualitative study utilized the stories of twelve LGBTQ + participants, including ten cisgender women, one transgender man, and one transmasculine/non-binary individual, planning to pursue ART services in the United States. Participants were recruited from Facebook groups for LGBTQ + individuals trying to conceive, and interviews were conducted via audio-only Zoom or phone. The interviews were transcribed and coded using reflexive thematic analysis with a constructivist paradigm, which yielded six main themes, one divided into three sub-themes. This study found that each LGBTQ + individual imagines their journey to parenthood through ART utilizing their unique circumstances, desires, and personal beliefs. These include, but are not limited to, the relative importance of genetic relatedness, the health risks of themselves, their partners, and future donors, and how they relate to their donor. Findings also included an emphasis on genetic ancestry and mental health. Even prior to ART, LGBTQ + couples express resilience to achieve their ultimate desire to be parents. Additionally, outside constraining barriers had a strong influence on ART access, method selection, and desire. Furthermore, participants expressed a want for both genetic and emotional support from GCs. Based on these findings, we recommend GCs be added as valuable care team members for LGBTQ + couples pursuing parenthood through ART.
Evaluation of Shear Bond Strength of Zirconia, E-max, and 3D-Printed Composite Resins with Various Resin Cements
Authors: Fahmi Mohammed
Published: January 2025

Objective:
This study aimed to evaluate the shear bond strength of zirconia, E-max, and 3D-printed composite resin when bonded with Panavia V5 and ResiCem EX cements.
Materials and Methods:
Shear bond strength was tested on six material-cement combinations: zirconia, E-max, and 3D-printed composite resin, each bonded with Panavia V5 and ResiCem EX. A total of 24 discs were prepared from each material, with 10 specimens in each group. The bonding interface was examined using a digital optical microscope. Shear bond strength was measured with an Instron universal testing machine, and statistical analysis was performed using two-way and one-way ANOVA.
Shear bond strength was tested on six material-cement combinations: zirconia, E-max, and 3D-printed composite resin, each bonded with Panavia V5 and ResiCem EX.
Results:
The highest shear bond strength was observed in 3D-printed composite resin bonded with Panavia V5 (20.74 MPa), significantly higher than Zirconia bonded with ResiCem EX (13.9 MPa, p = 0.010). No significant differences were noted between the remaining material-cement combinations.
Conclusion:
3D-printed composite resin demonstrated superior bond strength compared to zirconia and E-max, with Panavia V5 showing potential as a reliable cement for clinical applications. These findings underscore the potential of 3D-printed composites in restorative dentistry.
12th Rib Length as a Predictor of Anatomical Variations in the Lumbosacral Plexus Associated with Atypical Radiculopathy in Lumbar Disc Herniation
Authors: Anetai Hidaka , Teramoto Juri , Ono Takafumi , Kiribayashi Toshiaki , Nojiri Hidetoshi , Ohara Yukoh , Ishijima Muneaki , Ichimura Koichiro
Published: January 2025

Study Design: A combined clinical and cadaveric observational study.
Objectives: To investigate whether anatomical variations in the lumbosacral plexus (LSP) are associated with diagnostic discrepancies in lumbar disc herniation (LDH) and to corroborate clinical findings with anatomical evidence.
Summary of Background Data: LDH is typically diagnosed based on clinical neurological symptoms and the level of the compressed spinal nerve root (the responsible lesion) identified by magnetic resonance imaging. However, in some patients, radiculopathy symptoms do not always align with the responsible lesion, complicating the diagnosis. This discrepancy may be linked to anatomical variations in the LSP, although the exact cause remains unclear. LSP roots may exhibit cranio-caudal deviations, which tends to be associated with shorter or longer 12th ribs, providing a potential basis for investigation.
Methods: We examined 12th rib length in 144 patients with LDH at Juntendo University Hospital and investigated the relationship between LSP branch deviations and 12th rib length in 29 Japanese cadavers, donated to Juntendo University School of Medicine.
Results: Of the total, 102 cases showed matching radiculopathies and responsible lesions (matched group), while 42 cases exhibited discrepancies (mismatched group). The mismatched group was subdivided into: 19 cases with radiculopathy at a lower level than predicted by the responsible lesion (lower-level radiculopathy type) and 23 cases with radiculopathy at a higher level (higher-level radiculopathy). These types were significantly associated with shorter and longer 12th ribs, respectively, suggesting cranial and caudal deviations in LSP branches, confirmed by anatomical examination.
Conclusion: These findings suggest that contradictory neurological symptoms in LDH may be largely due to cranio-caudal deviations in the LSP and its branches. Furthermore, the 12th rib length may help predict these anatomical variations, potentially improving diagnostic accuracy in LDH.
Association of Podoplanin Expression with Histological Grade in Oral Squamous Cell Carcinoma in a Tertiary Care Hospital in Bangladesh
Authors: Jannat Mst.Rubeyatul , Abedin Nafisa , kashfi Sayeed Kishwara , Shirin Sadia , Ahamed Shamim , Sultana Shahana , Ahmed Mousumi , Barua Rita Rani
Published: January 2025

Background
Oral carcinogenesis is a complex process driven by genetic alterations affecting proto-oncogenes and tumor suppressor genes, with key players including P16, P53, H-ras, cyclinD1, and EGFR. Podoplanin, a transmembrane glycoprotein, has emerged as a biomarker implicated in tumor progression and prognosis in oral squamous cell carcinoma (OSCC). This study aimed to evaluate the immunohistochemical expression of podoplanin across different histological grades of OSCC and analyze its association with clinicopathological parameters such as age, gender, anatomical site, personal habits, lymphovascular and perineural invasion, and tumor-infiltrating lymphocytes.
Methods
A cross-sectional observational study was conducted at the Department of Pathology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) Hospital, Dhaka, Bangladesh, over two years. Fifty-six cases of OSCC were analyzed using hematoxylin and eosin-stained slides and paraffin-embedded tissue blocks. Podoplanin expression was assessed immunohistochemically, and staining intensity and extent were categorized as high or low.
Results
The results revealed high podoplanin expression in 33.90% of cases and low expression in 66.10%. High podoplanin expression was more frequently observed in moderately and poorly differentiated OSCC compared to well-differentiated tumors, with a statistically significant correlation between podoplanin expression and histological grade. However, no significant associations were identified between podoplanin expression and other factors, including age, gender, personal habits, anatomical site, lymphovascular invasion, perineural invasion, or tumor-infiltrating lymphocytes.
Conclusion
Podoplanin expression was significantly associated with the histological grade of OSCC, suggesting its potential role as a prognostic marker. High podoplanin expression may indicate aggressive tumor behavior and poor prognosis, underscoring its relevance in OSCC evaluation and management.
Analysis of the Kidney–Brain Axis via the Fractional Amplitude of Low-Frequency Fluctuation in Patients with Diabetic Nephropathy
Authors: lv jinlei
Published: January 2025

Background
Central neuropathies caused by diabetic nephropathy (DN) share similar characteristics. The present study aimed to analyze the changes in brain function of patients with DN based on the kidney–brain axis.
Methods
The study population consisted of patients with DN and healthy controls (n = 23 per group). Brain resting-state functional magnetic resonance imaging examination was performed on all participants, and the fractional amplitude of low-frequency fluctuation (fALFF) values were calculated. The diagnostic authenticity was assessed through receiver operating characteristic curves using sensitivity, specificity, and Youden index. Statistical analysis included Pearson's correlation between mean fALFF values and DN data.
Results
The imaging analysis revealed that DN patients exhibited lower fALFF values in the right cingulum anterior segment (RCA) and left cingulum middle segment, and increased fALFF values in the right cingulum middle segment compared to control subjects. The correlation analysis demonstrated that mean fALFF values in the RCA correlated with the estimated glomerular filtration rate in DN patients.
Conclusions
The research findings demonstrated significant differences in fALFF values in the default mode network and visual cortex-related areas. These observations may be highly valuable for understanding the kidney–brain axis mechanisms of DN, as well as the associations between diabetic microvascular complications.
Experience of using chemotherapy treatment for the first recurrence of ovarian cancer
Authors: Zhurman V. N.
Published: January 2025

Background. The main goal of treating patients with recurrent ovarian cancer is to prolong life and improve its quality. Approaches to the treatment of recurrent ovarian cancer have changed over the past decade. The choice of antitumor drug therapy is determined by the duration of platinum-free interval and the use of targeted therapy with bevacizumab or olaparib. Treatment regimens for relapses are not unified and treatment outcomes are contradictory. Aim: to analyze treatment outcomes of different chemotherapy regimens in patients with the first recurrence of ovarian cancer, depending on the duration of platinum-free interval. Material and Methods. A retrospective analysis of the first recurrence of ovarian cancer in 446 patients treated at the Primorsky Regional Oncology Center in the period 2004–2021 was carried out. All patients were divided into two groups depending on the treatment option for relapse: repeated cytoreduction followed by chemotherapy or only second-line chemotherapy, and into four groups depending on the chemotherapy regimens: 1 – platinum and taxane agents; 2 – platinum and taxane agents with bevacizumab; 3 – platinum agents and non-taxane agents with bevacizumab; 4 – monotherapy with non-platinum agents with bevacizumab. Results. Significant advantages in progression-free survival after second-line chemotherapy (PFS-2) were observed in patients with platinum-resistant relapse after the 4th chemotherapy regimen. Patients with platinum-sensitive relapse had the best treatment outcomes after the 3rd chemotherapy regimen and repeated cytoreduction followed by chemotherapy with a platinum-free interval of 6–12 months and 12–24 months with any platinum-containing chemotherapy regimen. In the platinum-free interval of more than 24 months, significant benefits were observed with a combination of platinum and taxane agents + bevacizumab. In the group of patients without surgery, there were significant benefits in all three intervals when prescribing a combination of platinum and non-oxane agents ± bevacizumab. There was a tendency to increase PFS-2 in patients with low-grade serous ovarian carcinoma compared with patients with high-grade serous carcinoma. The best rates of relapse-free survival were noted with maintenance therapy with olaparib. Conclusion. In patients with localized recurrence of ovarian cancer and a platinum-free interval of more than 6 months, it is advisable to perform repeated cytoreduction followed by chemotherapy, taking into account the duration of the platinum-free interval. The administration of PARP inhibitors in the maintenance therapy of platinum-sensitive recurrence of ovarian cancer improves treatment results.
Algorithms of training programs for simulator training of ship's engine room personnel
Authors: Vlasov A. B.
Published: January 2025

The ship's engine room personnel (mechanics, electromechanics) ensure the technical operation and safe functioning of the ship's power systems. Professional training and retraining of marine specialists of ship's engine rooms is necessary due to the constant improvement of equipment and automation of electric power systems of modern ships. To ensure high-quality training of the ship's engine room team, simulator training is used with a set of modern simulators of ship power plants and electric power systems that meet the standards of the International Convention on Standards of Training, Certification and Watchkeeping for Seafarers. In the course of the study, block diagrams of training algorithms have been developed; program features and examples of their operation have been shown. The obtained algorithms for training on simulators make it possible to implement both the initial training of cadets and the retraining of specialists when improving their qualifications. In the course of simulator practice, the opportunity to develop competencies for working with high-voltage equipment (3–10 kV) of modern ships in accordance with the requirements of the STCW Convention and the STCW Code is of particular importance. Algorithms for training in high-voltage equipment maintenance should be introduced into the educational process to improve the level of qualification of specialists.
Ballistic conductance with and without disorder in a boundary-driven XXZ spin chain
Authors: McRoberts Adam , Moessner Roderich
Published: January 2025

Motivated by recent experiments on Google’s sycamore NISQ platform on the spin transport resulting from a non-unitary periodic boundary drive of an XXZ chain, we study a classical variant thereof by a combination of analytical and numerical means. We find the classical model reproduces the quantum results in remarkable detail, and provides an analytical handle on the nature and shape of the spin transport’s three distinct regimes: ballistic (easy-plane), subdiffusive (isotropic) and insulating (easy-axis). Further, we show that this phenomenology is remarkably robust to the inclusion of bond disorder – albeit that the transient dynamics approaching the steady states differs qualitatively between the clean and disordered cases – providing an accessible instance of ballistic transport in a disordered setting.
The Android Application “Haji Pintar” And Independent Pilgrimage
Authors: Malik Hatta Abdul , Sulistio Sulistio , Jarong Koree
Published: January 2025

This article aims to find out the usability of the "Haji Pintar" Android application, Directorate General of PHU, Ministry of Religion, for the independence of Semarang City Hajj Pilgrims and to find out the factors that influence the low use of the Haji Pintar" application among Semarang City Hajj pilgrims. To achieve the objectives of this article, an exploratory study was used. The survey results showed a positive response to the usefulness of the application for Hajj independence for those who have performed the Hajj pilgrimage. Meanwhile, the factor that influences the low use of Haji Pintar applications is that the majority of Hajj pilgrims are elderly who have difficulty using devices.
Wayang Potehi at Hong San Kiong Temple in Gudo, Jombang, Indonesia: An Effort to Preserve the Culture and Religious Moderation
Authors: Masruroh Sayidah Afyatul
Published: January 2025

Indonesia’s rich cultural and religious diversity offers a unique context to explore how traditional arts contribute to social harmony. This article examines the Wayang Potehi performance at the Hong San Kiong Temple in Gudo, Jombang, and its role in promoting religious moderation. It highlights how performing arts are an inclusive platform that celebrates cultural and religious diversity, fostering tolerance and coexistence. The Hong San Kiong Temple, as a center for religious and cultural activities, provides an ideal setting to observe the integration of traditional arts like Wayang Potehi in pluralistic societies. The research uses a qualitative approach, including participatory observation, interviews, and document analysis, to understand how religious moderation is reflected in the performances. Findings indicate that Wayang Potehi conveys messages of moderation through its themes and the interaction between performers and audiences. These performances emphasize inclusivity, tolerance, and respect for diverse cultures and religions. The Hong San Kiong Temple’s efforts to promote religious moderation through these arts highlight a positive initiative that brings together diverse communities. This article offers valuable insights into how traditional arts can foster religious moderation and underscores the potential of performing arts in religious spaces to bridge divides in multicultural societies.