bluuebunny/crossref_metadata_2025 huggingface dataset:
Decade-long monitoring of seismic velocity changes at the Irpinia fault system (southern Italy) reveals pore pressure pulsations
Authors: De Landro G. , Amoroso O. , Russo G. , D’Agostino N. , Esposito R. , Emolo A. , Zollo A.
Published: January 2022

Several studies have monitored crustal seismic velocity changes and attempted to relate them to the stress state and physical properties in volume embedding fault systems. The aim is to provide constraints on fault system dynamics and earthquake triggering mechanisms. Here, we reconstruct the spatiotemporal (4D) seismic velocity images of volume embedding the Irpinia fault system (IFS, South Italy), which originated the 1980 Ms 6.9 multi-segmented ruptures. By inverting data from more than ten years of continuous seismicity monitoring, we retrieved time-constant velocity anomalies, whose shapes correlate well with crustal lithology, while time-changing (up to 20%) velocity anomalies are mapped in the central region. Here, the Vp-to-Vs changes at depths of 1–5 km and 8–12 km correlate well with groundwater recharge and geodetic displacement during the same time interval. This correlation provides evidence for the existence of pulsating, pore pressure changes induced by groundwater recharge processes in a deep volume (8–12 km of depth), fractured and saturated with a predominant gas phase (likely CO2). We suggest that tomographic measurements of the Vp-to-Vs spatiotemporal changes are a suitable proxy to track the pore pressure evolution at depth in highly sensitive regions of fault systems.
RUNX3 overexpression inhibits normal human erythroid development
Authors: Menezes Ana Catarina , Dixon Christabel , Scholz Anna , Nicholson Rachael , Leckenby Adam , Azevedo Aleksandra , Baker Sarah , Gilkes Amanda F. , Davies Sara , Darley Richard L. , Tonks Alex
Published: January 2022

RUNX proteins belong to a family of transcription factors essential for cellular proliferation, differentiation, and apoptosis with emerging data implicating RUNX3 in haematopoiesis and haematological malignancies. Here we show that RUNX3 plays an important regulatory role in normal human erythropoiesis. The impact of altering RUNX3 expression on erythropoiesis was determined by transducing human CD34+ cells with RUNX3 overexpression or shRNA knockdown vectors. Analysis of RUNX3 mRNA expression showed that RUNX3 levels decreased during erythropoiesis. Functionally, RUNX3 overexpression had a modest impact on early erythroid growth and development. However, in late-stage erythroid development, RUNX3 promoted growth and inhibited terminal differentiation with RUNX3 overexpressing cells exhibiting lower expression of glycophorin A, greater cell size and less differentiated morphology. These results suggest that suppression of RUNX3 is required for normal erythropoiesis. Overexpression of RUNX3 increased colony formation in liquid culture whilst, corresponding RUNX3 knockdown suppressed colony formation but otherwise had little impact. This study demonstrates that the downregulation of RUNX3 observed in normal human erythropoiesis is important in promoting the terminal stages of erythroid development and may further our understanding of the role of this transcription factor in haematological malignancies.
Effect of interleukin-1 blockade with anakinra on leukocyte count in patients with ST-segment elevation acute myocardial infarction
Authors: Del Buono Marco Giuseppe , Damonte Juan Ignacio , Trankle Cory R. , Kadariya Dinesh , Carbone Salvatore , Thomas Georgia , Turlington Jeremy , Markley Roshanak , Canada Justin M. , Biondi‐Zoccai Giuseppe G. , Kontos Michael C. , Van Tassell Benjamin W. , Abbate Antonio
Published: January 2022

Leukocytosis is a common finding in patients with ST elevation myocardial infarction (STEMI) and portends a poor prognosis. Interleukin 1-β regulates leukopoiesis and pre-clinical studies suggest that anakinra (recombinant human interleukin-1 [IL-1] receptor antagonist) suppresses leukocytosis in myocardial infarction. However, the effect of IL-1 blockade with anakinra on leukocyte count in patients with STEMI is unknown. We reviewed the white blood cell (WBC) and differential count of 99 patients enrolled in a clinical trial of anakinra (n = 64) versus placebo (n = 35) for 14 days after STEMI. A complete blood cell count with differential count were obtained at admission, and after 72 h, 14 days and 3 months. After 72 h from treatment, anakinra compared to placebo led to a statistically significant greater percent reduction in total WBC count (− 35% [− 48 to − 24] vs. − 21% [− 34 to − 10], P = 0.008), absolute neutrophil count (− 48% [− 60 to − 22] vs. − 27% [− 46 to − 5], P = 0.004) and to an increase in absolute eosinophil count (+ 50% [0 to + 100] vs. 0% [− 50 to + 62], P = 0.022). These changes persisted while on treatment at 14 days and were no longer apparent at 3 months after treatment discontinuation. We found that in patients with STEMI IL-1 blockade with anakinra accelerates resolution of leukocytosis and neutrophilia. This modulation may represent one of the mechanisms by which IL-1 blockade improves clinical outcomes.
Parity status and the relationship between antenatal rubella serology with obstetric outcome
Authors: Lao Terence T. , Hui Shuk Yi Annie , Sahota Daljit S.
Published: January 2022

Routine antenatal rubella serological testing is adopted in many countries. In a population covered by universal childhood rubella immunization for four decades, we have observed an association between pre-eclampsia with maternal rubella seronegativity among multiparous gravidae. This retrospective cohort study was further performed to elucidate the interaction between parity status and rubella seronegativity on obstetric outcome in singleton pregnancies carried to ≥ 24 weeks gestation managed from 1997 to 2019, with the data retrieved from a computerized database used for annual statistics and auditing. Of the 133,926 singleton pregnancies eligible for the study, the 13,320 (9.9%) rubella seronegative gravidae had higher mean booking weight and body mass index (BMI), but shorter height, and higher incidence of advanced age (≥ 35 years), high BMI, short stature, and lower incidence of nulliparas. Univariate analysis showed that adverse obstetric outcomes were more frequently found among the multiparas. On multivariate analysis, there was increased postdated (> 41 weeks) pregnancy irrespective of parity status, while nulliparas had reduced gestational hypertension (aRR 0.714, 95% CI 0.567–0.899) and gestational diabetes (aRR 0.850, 95% CI 0.762–0.950), and multiparas had increased pre-eclampsia (aRR 1.261, 95% CI 1.005–1.582), neonatal death (aRR 2.796, 95% CI 1.243–6.291), and perinatal death (aRR 2.123, 95% CI 1.257–3.587). In conclusion, in a population covered by universal childhood rubella immunization, antenatal rubella seronegativity is associated with increased pre-eclampsia and perinatal loss only in multiparas, suggesting that the rubella seronegativity in these women served as proxy for some form of altered immune response which increases adverse pregnancy outcome.
Predictors of circuit health in neonatal patients receiving extracorporeal membrane oxygenation (ECMO)
Authors: Hazboun Rita G. , Darwish Nada , Rotyliano-Sykes Gianna , Chahin Nayef , Xu Jie , Miller John , Calaritis Christos , Thacker Leroy , Moores Russell , Hendricks-Muñoz Karen D.
Published: January 2022

To identify predictors of neonatal ECMO circuit health, a retrospective analysis of circuit functional pressure and flow parameters as well as infant clotting values were collected 48 h prior to and 24 h post circuit change. Circuit impairment was defined as need for partial or total circuit change. Statistical analysis used multivariate statistics and non-parametric Mann–Whitney U-test with possible non-normality of measurements. A total of 9764 ECMO circuit and clotting values in 21 circuits were analyzed. Circuit delta-P mean, and maximum values increased from 8.62 to 48.59 mmHg (p < 0.011) and 16.00 to 53.00 mmHg (p < 0.0128) respectively prior to need for circuit change. Maximum and mean Pump Flow Revolutions per minute (RPM) increased by 75% (p < 0.0043) and 81% (p < 0.0057), respectively. Mean plasma free hemoglobin (pfHb) increased from 26.45 to 76.00 mg/dl, (p < 0.0209). Sweep, venous pressure, and clotting parameters were unaffected. ECMO circuit delta-P, RPM, and pfHb were early predictors of circuit impairment.
Study on the effect of koumiss on the intestinal microbiota of mice infected with Toxoplasma gondii
Authors: Yan Xinlei , Han Wenying , Jin Xindong , Sun Yufei , Gao Jialu , Yu Xiuli , Guo Jun
Published: January 2022

Toxoplasma gondii is a worldwide food-borne parasite that can infect almost all warm-blooded animals, including humans. To date, there are no effective drugs to prevent or eradicate T. gondii infection. Recent studies have shown that probiotics could influence the relationship between the microbiota and parasites in the host. Koumiss has been used to treat many diseases based on its probiotic diversity. Therefore, we explored the effect of koumiss on T. gondii infection via its effect on the host intestinal microbiota. BALB/c mice were infected with T. gondii and treated with PBS, koumiss and mares’ milk. Brain cysts were counted, and long-term changes in the microbiota and the effect of koumiss on gut microbiota were investigated with high-throughput sequencing technology. The results suggested that koumiss treatment significantly decreased the cyst counts in the brain (P < 0.05). Moreover, T. gondii infection changed the microbiota composition, and koumiss treatment increased the relative abundance of Lachnospiraceae and Akkermansia muciniphila, which were associated with preventing T. gondii infection. Moreover, koumiss could inhibit or ameliorate T. gondii infection by increasing the abundance of certain bacteria that control unique metabolic pathways. The study not only established a close interaction among the host, intracellular pathogens and intestinal microbiota but also provided a novel focus for drug development to prevent and eradicate T. gondii infection.
Planar polarity in primate cone photoreceptors: a potential role in Stiles Crawford effect phototropism
Authors: Verschueren Anna , Boucherit Leyna , Ferrari Ulisse , Fouquet Stéphane , Nouvel-Jaillard Céline , Paques Michel , Picaud Serge , Sahel José-Alain
Published: January 2022

Human cone phototropism is a key mechanism underlying the Stiles-Crawford effect, a psychophysiological phenomenon according to which photoreceptor outer/inner segments are aligned along with the direction of incoming light. However, such photomechanical movements of photoreceptors remain elusive in mammals. We first show here that primate cone photoreceptors have a planar polarity organized radially around the optical center of the eye. This planar polarity, based on the structure of the cilium and calyceal processes, is highly reminiscent of the planar polarity of the hair cells and their kinocilium and stereocilia. Secondly, we observe under super-high resolution expansion microscopy the cytoskeleton and Usher proteins architecture in the photoreceptors, which appears to establish a mechanical continuity between the outer and inner segments. Taken together, these results suggest a comprehensive cellular mechanism consistent with an active phototropism of cones toward the optical center of the eye, and thus with the Stiles-Crawford effect.
Designing and interpreting 4D tumour spheroid experiments
Authors: Murphy Ryan J. , Browning Alexander P. , Gunasingh Gency , Haass Nikolas K. , Simpson Matthew J.
Published: January 2022

Tumour spheroid experiments are routinely used to study cancer progression and treatment. Various and inconsistent experimental designs are used, leading to challenges in interpretation and reproducibility. Using multiple experimental designs, live-dead cell staining, and real-time cell cycle imaging, we measure necrotic and proliferation-inhibited regions in over 1000 4D tumour spheroids (3D space plus cell cycle status). By intentionally varying the initial spheroid size and temporal sampling frequencies across multiple cell lines, we collect an abundance of measurements of internal spheroid structure. These data are difficult to compare and interpret. However, using an objective mathematical modelling framework and statistical identifiability analysis we quantitatively compare experimental designs and identify design choices that produce reliable biological insight. Measurements of internal spheroid structure provide the most insight, whereas varying initial spheroid size and temporal measurement frequency is less important. Our general framework applies to spheroids grown in different conditions and with different cell types.
Lamina-specific immunohistochemical signatures in the olfactory bulb of healthy, Alzheimer’s and Parkinson’s disease patients
Authors: Murray Helen C. , Johnson Kory , Sedlock Andrea , Highet Blake , Dieriks Birger Victor , Anekal Praju Vikas , Faull Richard L. M. , Curtis Maurice A. , Koretsky Alan , Maric Dragan
Published: January 2022

Traditional neuroanatomy immunohistology studies involve low-content analyses of a few antibodies of interest, typically applied and compared across sequential tissue sections. The efficiency, consistency, and ultimate insights of these studies can be substantially improved using high-plex immunofluorescence labelling on a single tissue section to allow direct comparison of many markers. Here we present an expanded and efficient multiplexed fluorescence-based immunohistochemistry (MP-IHC) approach that improves throughput with sequential labelling of up to 10 antibodies per cycle, with no limitation on the number of cycles, and maintains versatility and accessibility by using readily available commercial reagents and standard epifluorescence microscopy imaging. We demonstrate this approach by cumulatively screening up to 100 markers on formalin-fixed paraffin-embedded sections of human olfactory bulb sourced from neurologically normal (no significant pathology), Alzheimer’s (AD), and Parkinson’s disease (PD) patients. This brain region is involved early in the symptomology and pathophysiology of AD and PD. We also developed a spatial pixel bin analysis approach for unsupervised analysis of the high-content anatomical information from large tissue sections. Here, we present a comprehensive immunohistological characterisation of human olfactory bulb anatomy and a summary of differentially expressed biomarkers in AD and PD using the MP-IHC labelling and spatial protein analysis pipeline.
Three-dimensional gold nanowires with high specific surface area for simultaneous detection of heavy metal ions
Authors: Wu Tingxia , Zhu Yongbao , Song Lingyu , Chen Yizhe , Huang Yufu , Tang Junping , Ma Xinzhou , Wang Hanchun , Zhang Jun , Lin Donghai , Chen Guosong
Published: January 2022

Traditional detection methods to detect heavy metal ions are time-consuming, complicated, and expensive.
A highly selective 2′′-O-glycosyltransferase fromZiziphus jujubaandDe novobiosynthesis of isovitexin 2′′-O-glucoside
Authors: Zhang Ya-Qun , Wang Zi-Long , Chen Zhuo , Jin Zheng-Tong , Hasan Aobulikasimu , Wang Hai-Dong , Sun Yu-Wei , Qiao Xue , Wang Yong , Ye Min
Published: January 2022

We report a novel 2′′-O-glycosyltransferase indicating a new biosynthetic pathway of flavonoidO-glycosyl-C-glycosides.
Evaluation of the binding mode of a cytotoxic dinuclear nickel complex to two neighboring phosphates of the DNA backbone
Authors: Simon Jasmin , Horstmann née Gruschka Claudia , Mix Andreas , Stammler Anja , Oldengott Jan , Bögge Hartmut , Glaser Thorsten
Published: January 2022

The binding of phosphate diesters to cytotoxic NiII complexes has been studied by single-crystal X-ray crystallography, NMR titration, and computational chemistry to evaluate the binding mode of these complexes to the phosphate backbone of DNA.
Remarkable structure and luminescence regulation of a Gd2LuAl5O12:Ce garnet phosphor with a Ca2+/Si4+ pair for high-quality w-WLED lighting
Authors: Meng Qinghong , Zhao Guoying , Zhu Qi , Sun Xudong , Li Ji-Guang
Published: January 2022

Gd1.97−xLuCaxAl5−xSixO12:0.03Ce garnet new phosphors were developed for high-CRI w-WLED lighting, and the influence of the Ca2+/Si4+ pair on the crystal structure, local coordination and Ce3+ luminescence was deciphered.
Structural determinations and magnetic properties of a “chiral at metal” complex and its resulting [Cu–Ln]2 compounds
Authors: Costes Jean-Pierre , Duhayon Carine , Vendier Laure , Wernsdorfer Wolfgang
Published: January 2022

Reaction of the (S)-[LCu]pipH complex with LnIII ions does not allow to keep the stereogenic Cu centre present in the starting CuII complex.
Formation, aggregation, and transport of NOM–Cr(iii) colloids in aquatic environments
Authors: Li Binrui , Liao Peng , Liu Peng , Wang Dengjun , Ye Zhihang , Wang Jingfu , Chen Jingan , Ning Zigong , Jiang Yi , Liu Chongxuan
Published: January 2022

This study provides nanoscale and molecular-scale evidence that the formation, stability, and transport of NOM–Cr(iii) colloids depend on the C/Cr ratio and NOM source.
Improved anaerobic degradation of purified terephthalic acid wastewater by adding nanoparticles or co-substrates to facilitate the electron transfer process
Authors: Li Heng , Zhang Weidong , Xia Dong , Ye Lingfen , Ma Wende , Li Haiyan , Li Qingbiao , Wang Yuanpeng
Published: January 2022

Improving the biodegradation efficiency of terephthalic acid (TA) wastewater processes is highly challenging, particularly in large-scale up-flow anaerobic sludge blanket (UASB) reactors.
Sesquiterpene glycoside isolated from loquat leaf targets gut microbiota to prevent type 2 diabetes mellitus in db/db mice
Authors: Wu Ruoyun , Zhou Lina , Chen Yan , Ding Xiaoqin , Liu Yan , Tong Bei , Lv Han , Meng Xiuhua , Li Jing , Jian Tunyu , Chen Jian
Published: January 2022

• SG1 prevents obesity, ameliorates insulin resistance, and reduces systemic inflammation. • SG1 keeps the gut microbial diversity. •The efficacy of SG1 in the treatment of T2DM is strongly linked with the enhancement of several gut genera.
The effect of hydroxy citric acid supplementation with calorie-restricted diet on metabolic, atherogenic and inflammatory biomarkers in women with non-alcoholic fatty liver disease: a randomized controlled clinical trial
Authors: Arefhosseini Sara , Tutunchi Helda , Nomi-Golzar Solmaz , Mahboob Soltanali , Pouretedal Zohre , Ebrahimi-Mameghani Mehrangiz
Published: January 2022

Possible mechanisms of action of hydroxy citric acid (HCA) in the management of NAFLD.
Active learning of polarizable nanoparticle phase diagrams for the guided design of triggerable self-assembling superlattices
Authors: Dasetty Siva , Coropceanu Igor , Portner Joshua , Li Jiyuan , de Pablo Juan J. , Talapin Dmitri , Ferguson Andrew L.
Published: January 2022

Coarse-grained molecular modeling and active learning enable the design of polarizable nanoparticles capable of triggered assembly and disassembly.
Diindolocarbazole – achieving multiresonant thermally activated delayed fluorescence without the need for acceptor units
Authors: Hall David , Stavrou Kleitos , Duda Eimantas , Danos Andrew , Bagnich Sergey , Warriner Stuart , Slawin Alexandra M. Z. , Beljonne David , Köhler Anna , Monkman Andrew , Olivier Yoann , Zysman-Colman Eli
Published: January 2022

We present a new multi-resonance thermally activated delayed fluorescence (MR-TADF) emitter paradigm, demonstrating that the structure need not require the presence of acceptor atoms.
High-coercivity hexaferrite ceramics featuring sub-terahertz ferromagnetic resonance
Authors: Gorbachev Evgeny A. , Trusov Lev A. , Alyabyeva Liudmila N. , Roslyakov Ilya V. , Lebedev Vasily A. , Kozlyakova Ekaterina S. , Magdysyuk Oxana V. , Sobolev Alexey V. , Glazkova Iana S. , Beloshapkin Sergey A. , Gorshunov Boris P. , Kazin Pavel E.
Published: January 2022

Dense ceramics were obtained by annealing single-domain Al-doped hexaferrite particles. The materials possess giant coercivities and natural ferromagnetic resonance at 160–280 GHz. A large blueshift of the ferromagnetic resonance frequency was found.
Understanding sodium storage properties of ultra-small Fe3S4 nanoparticles – a combined XRD, PDF, XAS and electrokinetic study
Authors: Hartmann Felix , Etter Martin , Cibin Giannantonio , Groß Hendrik , Kienle Lorenz , Bensch Wolfgang
Published: January 2022

The Na storage mechanism of Fe3S4 nanoparticles is studied via electrochemical techniques, synchrotron-based X-ray diffraction and absorption methods. The results explain the relation of the electrodes cycle life and cut-off potentials.
Evidence for stereoelectronic effects in ligand exchange reactions on Au25 nanoclusters
Authors: Wang Yanan , Bürgi Thomas
Published: January 2022

Fluoro-substituted ligands attached on a gold cluster slow down subsequent ligand exchange reactions. The clusters obtained through ligand exchange with mixtures show non-statistical ligand distribution, revealing a stereoelectronic effect.
Synthesis of functionalized malononitriles via Fe-catalysed hydrogen atom transfers of alkenes
Authors: Zhu Tianxiang , Zhang Xue-jun , Zhou Zihan , Xu Zitong , Ma Mengtao , Zhao Binlin
Published: January 2022

A practical and convenient approach that enabled radical-mediated conjugate addition of unreactive alkenes to electron-deficient alkenes leading to a broad range of substituted malononitriles was disclosed.
Ru(ii)-Catalyzed C–H bond activation/annulation of N-iminopyridinium ylides with sulfoxonium ylides
Authors: Li Xiang , Li Danlu , Zhang Xiaofei
Published: January 2022

A Ru(ii)-catalyzed C–H bond activation/annulation of N-iminopyridinium ylides with sulfoxonium ylides has been developed, which afforded isocoumarins in moderate to good yields.
Trifluoromethoxy-substituted nickel catalysts for producing highly branched polyethylenes: impact of solvent, activator andN,N′-ligand on polymer properties
Authors: Liu Ming , Zhang Randi , Ma Yanping , Han Mingyang , Solan Gregory A. , Yang Wenhong , Liang Tongling , Sun Wen-Hua
Published: January 2022

Highly branched and narrowly dispersed polyethylenes with high or ultra-high molecular weights are accessible using the depicted nickel precatalyst/activator combinations.
Bond energy enabled amine distinguishing strategy: chemo-, regioselective 1,3-diamination of (trifluoromethyl)alkenes with different amines by two C(sp3)–F bond cleavages
Authors: Zeng Hao , Li Hengyuan , Li Chengxi , Jiang Huanfeng , Zhu Chuanle
Published: January 2022

ipso-Defluorinative amination-triggered 1,3-diamination of (trifluoromethyl)alkenes with different amines affords various monofluoroalkenylated acyclic 1,3-diamines in high yields with excellent Z/E selectivity.
Direct synthesis of N2-unprotected five-membered cyclic guanidines by regioselective [3 + 2] annulation of aziridines and cyanamides
Authors: Wang Chuan-Chuan , Wang Xin-Lu , Zhang Qing-Ling , Liu Juntao , Ma Zhi-Wei , Liu Zhi-Jing , Chen Ya-Jing
Published: January 2022

This work disclosed the first direct synthesis of N2-unprotected five-membered cyclic guanidines via a regioselective ring-opening/5-exo-dig cyclization strategy between aziridines and cyanamides under mild conditions.
Antiaromaticity-promoted radical anion stability in α-vinyl heterocyclics
Authors: Lin Lu , Zhu Jun
Published: January 2022

Theoretical calculations demonstrate that releasing the antiaromaticity of a neutral species could generate thermodynamically more stable radical anions over a neutral (non)aromatic compound.
Highly stretchable transparent bar coated Ag NW/PEDOT:PSS hybrid electrode for wearable and stretchable devices
Authors: Lee Ju-Hyeon , Raman Vivekanandan , Kang Chaeyoung , Ha Hyun-Uk , Seok Hae-Jun , Kim Han-Ki
Published: January 2022

PEDOT:PSS, the highly stretchable and conductive polymer, can enhances the stretchability of Ag NW electrodes when mixed with Ag NW. Because PEDOT:PSS is still connected to the disconnected Ag NWs, the electrode has enhanced stretchability.
Antimicrobial activity of silver sulfide quantum dots functionalized with highly conjugated Schiff bases in a one-step synthesis
Authors: Shahri Nurulizzatul Ningsheh M. , Taha Hussein , S. A. Hamid Malai Haniti , Kusrini Eny , Lim Jun-Wei , Hobley Jonathan , Usman Anwar
Published: January 2022

In the present paper, low-dimensional Ag2S QDs were fabricated for the first time, with four different dithiocarbazate derivative Schiff bases (SB) as capping agents in a one-pot synthesis.
A salicylaldehyde benzoyl hydrazone based near-infrared probe for copper(ii) and its bioimaging applications
Authors: Zhao Jie , Wang Yue-yuan , Chen Wen-ling , Hao Guang-shu , Sun Jian-ping , Shi Qing-fang , Tian Fang , Ma Run-tian
Published: January 2022

A near infrared fluorescent probe utilizing the salicylaldehyde benzoyl hydrazone group as the Cu2+ receptor was developed and used to selectively and sensitively monitor Cu2+ in living systems.
Effect of sequence distribution of block copolymers on the interfacial properties of ternary mixtures: a dissipative particle dynamics simulation
Authors: Liu Dongmei , Lin Ye , Bo Huifeng , Li Deyang , Gong Kai , Zhang Zhanxin , Li Sijia
Published: January 2022

In this paper, the dissipative particle dynamics (DPD) simulations method is used to study the effect of sequence distribution of block copolymers on the interfacial properties between immiscible homopolymers.
Phase transformations in the nickel phosphide system induced by transition-metal doping and their electro-catalytic study
Authors: Ayom Gwaza E. , Khan Malik D. , Masikane Siphamandla C. , de Souza Felipe M. , Lin Wang , Gupta Ram K. , Revaprasadu Neerish
Published: January 2022

Nickel phosphides were formed from Ni salt in TOPO/TOP or HDA/TOP and phase transformations from Ni2P to Ni5P4 and vice versa was observed by doping with Cu or Mn salts. Doping effect on phase transition and electrocatalytic properties is studied.
Performance enhancement strategies for surface plasmon resonance sensors in direct glucose detection using pristine and modified UiO-66: effects of morphology, immobilization technique, and signal amplification
Authors: Gumilar Gilang , Henzie Joel , Yuliarto Brian , Patah Aep , Nugraha Nugraha , Iqbal Muhammad , Amin Mohammed A. , Hossain Md. Shariar A. , Yamauchi Yusuke , Kaneti Yusuf Valentino
Published: January 2022

Au nanoparticles encapsulated in UiO-66 MOF were hybridized with Au films to generate strong coupling between their plasmon resonances. Glucose absorbing to UiO-66 modulates the local permittivity, which can be detected by the SPR sensor.
Prospective advances in MXene inks: screen printable sediments for flexible micro-supercapacitor applications
Authors: Azadmanjiri Jalal , Reddy Thuniki Naveen , Khezri Bahareh , Děkanovský Lukáš , Parameswaran Abhilash Karuthedath , Pal Bhupender , Ashtiani Saeed , Wei Shuangying , Sofer Zdeněk
Published: January 2022

Micro-supercapacitor applications of flexible devices with screen printable MXene sediment inks.
Ion-selective aramid nanofiber-based Janus separators fabricated by a dry-wet phase inversion approach for lithium–sulfur batteries
Authors: Pei Huijie , Yang Chengyin , Wu Qiyue , Zhou Xingping , Xie Xiaolin , Hwang Bingjoe , Ye Yunsheng
Published: January 2022

A large-area p-aramid nanofiber-based Janus separator containing an ion-selective nanoporous layer and a microporous layer fabricated by a facile dry-wet phase inversion method exhibits high porosity, an optimal pore size, exceptional electrolyte wettability, and thermal stability.
A multifunctional cobalt iron sulfide electrocatalyst for high performance Zn–air batteries and overall water splitting
Authors: Kumar Mukesh , Nagaiah Tharamani C.
Published: January 2022

Multifunctional nanorod embedded wheat-grain CoFe(3:1)S2 was synthesized in a simple single-step hydrothermal reaction and demonstrated outstanding performance in Zn–air batteries and overall water splitting.
Engineering V2O3 nanoarrays with abundant localized defects towards high-voltage aqueous supercapacitors
Authors: Chen Shuai , Xu Qiucheng , Chen Ling , Hu Yanjie , Jiang Hao , Li Chunzhong
Published: January 2022

Defect engineering on V2O3 exhibits great potential to decrease the energy barrier of ion diffusion; meantime, it expedites the electron transfer rate.
Cross-linked structure of self-aligned p-type SnS nanoplates for highly sensitive NO2 detection at room temperature
Authors: Song Young Geun , Baek In-Hwan , Yim Jae-Gyun , Eom Taeyong , Chung Taek-Mo , Lee Chul-Ho , Hwang Cheol Seong , Kang Chong-Yun , Kim Seong Keun
Published: January 2022

A highly sensitive NO2 gas sensor of p-type SnS operating at room temperature is developed using crosslinked SnS nanoplates self-formed only on SiO2 nanorods, without an additional patterning process.
An in situ spontaneously forming micelle-hydrogel system with programmable release for the sequential therapy of anaplastic thyroid cancer
Authors: Yang Xi , Zhang Lingyun , Zheng Lingnan , Wang Yan , Gao Ling , Luo Rui , Li Xinchao , Gong Changyang , Luo Han , Wu Qinjie
Published: January 2022

An in situ spontaneously forming micelle-hydrogel system was developed for localized sequential chemotherapy; it released drugs programmatically and exerted remarkable anti-tumor efficacy.
Polyphenol-modified nanovesicles for synergistically enhanced in vitro tumor cell targeting and apoptosis
Authors: Seo Jihye , Kim Seulgi , Lee Yousong , Kim Jiwon , Lee Youngbok , Shin Mikyung , Kim Jin Woong
Published: January 2022

A cancer cell-targeting peptide-conjugated tannic acid-modified nanovesicle system is proposed to establish a promising drug delivery system for cancer treatment.
Thionated PDI supramolecular polymers: controlling aggregation mechanisms, morphology and function
Authors: Symons Henry E. , Hagemann Maximilian J. L. , Harniman Robert L. , Faul Charl F. J.
Published: January 2022

Thionation of a model perylene diimide has a significant impact on its self-assembly behaviour. This approach provides a facile route to simultaneously exert control over the mechanism, morphology and functionality of self-assembled PDI materials.
Electronic and energy level engineering of directly fused porphyrin-conjugated polymers – impact of the central metal cation
Authors: Cardenas-Morcoso Drialys , Vey Eloa , Heiderscheid Max , Frache Gilles , Boscher Nicolas D.
Published: January 2022

The constitution and optoelectronic properties of directly fused-metalloporphyrin coatings prepared by the oCVD method are strongly influenced by the chelated cation on the porphyrin core, directing their potential toward photocatalytic applications.
In situ, seed-free formation of a Ruddlesden–Popper perovskite Cs2PbI2Cl2 nanowires/PbI2 heterojunction for a high-responsivity, self-powered photodetector
Authors: Ba Yanshuang , Xie Xiaoping , Zhu Weidong , Ma Junxiao , Liu Gang , Dong Peng , Chen Dazheng , Zhang Jincheng , Zhang Chunfu , Hao Yue
Published: January 2022

The Cs2PbI2Cl2 nanowires/PbI2 heterojunction enlarged the built-in field (Eb), which led to the suppressed carrier recombination and enhanced carrier transportation. The resulting device reached a specific detectivity (D*) maximum of 3.02 × 1012 Jones.
Very bright and efficient ITO-free narrow-spectrum micro-cavity top-emitting organic light-emitting diodes with low operation voltage
Authors: Li Xiaokang , Liu Wenxing , Chen Kai , Yu Chunyu , Xia Xiaoyang , Liu Guojun , Zhou Liang
Published: January 2022

Top-emitting organic light-emitting diodes (TEOLEDs) achieved an ultra-high power efficiency of up to 186.38 lm W−1, an impressive EQE as high as 47.4%, and a low operation voltage.
Nitrogen-doped biochar nanosheets facilitate charge separation of a Bi/Bi2O3 nanosphere with a Mott–Schottky heterojunction for efficient photocatalytic reforming of biomass
Authors: Jin Dongnv , Ma Jiliang , Sun Runcang
Published: January 2022

Nitrogen-doped biochar nanosheets facilitate the charge separation of Bi/Bi2O3 nanospheres with a Mott–Schottky heterojunction for efficient photocatalytic reforming of biomass.
A multicolor-switchable fluorescent lanthanide MOFs triggered by anti-cancer drugs: multifunctional platform for anti-cancer drug sensing and information anticounterfeiting
Authors: Zhang Yu , Xu Xin , Yan Bing
Published: January 2022

Lanthanide metal organic frameworks (Ln-MOFs) as excellent fluorescent materials have shown enormous potential applications, especially in fluorescence sensing and anticounterfeiting.
Engineering optimal vaccination strategies: effects of physical properties of the delivery system on functions
Authors: Zhu Ge , Yang Yong-Guang , Sun Tianmeng
Published: January 2022

This review summarizes the recent advances and insights into the applications of drug delivery systems (DDSs) in vaccination and the impacts of the major physical properties of DDSs on the success of vaccination.
Recent advances in photocatalytic nitrogen fixation and beyond
Authors: Wei Yunxia , Jiang Wenjun , Liu Yang , Bai Xiaojuan , Hao Derek , Ni Bing-Jie
Published: January 2022

The traditional synthesis of ammonia is an industrial process with high energy consumption that is not environmentally friendly; thus, it is urgent to develop cost-effective approaches to synthesize ammonia under ambient conditions.
Investigation of BaO reinforced TiO2–p2O5–li2O glasses for optical and neutron shielding applications
Authors: Shaaban Kh. S. , Al-Baradi Ateyyah M. , Ali Atif Mossad
Published: January 2022

The optical and radiation shielding characteristics of 15TiO2–70P2O5 – (15 − x) Li2O-x BaO x = (0 ≤ x ≤ 10 mol%) glasses were reported in this study.
Correction: Rational design of Fe3O4@C nanoparticles for simultaneous bimodal imaging and chemo-photothermal therapy in vitro and in vivo
Authors: Han Qinghe , Wang Xiaodong , Sun Zhiqiang , Xu Xiaofei , Jin Longhai , Qiao Lixin , Yuan Qinghai
Published: January 2022

Correction for ‘Rational design of Fe3O4@C nanoparticles for simultaneous bimodal imaging and chemo-photothermal therapy in vitro and in vivo’ by Qinghe Han et al., J. Mater. Chem. B, 2018, 6, 5443–5450, DOI: 10.1039/C8TB01184B.
An enhanced finite control set model predictive control method with self‐balancing capacitor voltages for three‐level T‐type rectifiers
Authors: Bayhan Sertac , Komurcugil Hasan , Guler Naki
Published: January 2022

An effective finite control set model predictive control (FCS‐MPC) is introduced for single‐phase three‐level T‐type rectifiers supplying resistive as well as constant power loads (CPL). The main problem of CPL is the negative resistance phenomenon that endangers the rectifier's stability. Hence, the proposed FCS‐MPC method is based on Lyapunov's stability theory such that the stability of the rectifier is guaranteed under all operating points. Unlike the existing FCS‐MPC methods, the cost function design in the proposed control method is formulated on the rectifier's stability. According to Lyapunov's stability theory, the rectifier stays stable provided that the rate of change of Lyapunov function is negative. In this case, the derivative of the Lyapunov function can be used as the cost function without utilizing any weighting factor. Therefore, contrary to the existing FCS‐MPC methods, the weighting factor requirement is eliminated which leads to easiness in the design and implementation of the controller. Experimental results reveal that the proposed control approach exhibits very good performance with undistorted and distorted grid voltage conditions when the rectifier feeds resistive and CPL loads.
Optimal power scheduling of seaport microgrids with flexible logistic loads
Authors: Fang Sidun , Wang Chenxu , Liao Ruijin , Zhao Changhong
Published: January 2022

Seaports are progressively electrified to harness various energy resources to provide green logistic services to ships. They essentially act as multi‐energy microgrids to enhance the energy efficiency and environmental sustainability of the maritime industry. This trend necessitates the coordinated operation of multiple sectors in seaport microgrids, which is a challenging problem due to the complex couplings of power, thermal, and fluid flows and the heterogeneity of logistic loads. An optimal power scheduling framework for seaport microgrids is developed. Specifically, a non‐linear, non‐convex optimisation problem is formulated to integrate various logistic loads, including cold ironing, quay and yard cranes, and reefer areas, in an unbalanced multi‐phase power distribution network connected with a thermal network. The optimisation problem is solved in a scalable decomposed manner based on iterative convex relaxation and approximation. Simulation results on a real‐world port model verify the efficacy of the proposed framework, as well as the potential of the flexible logistic loads in improving port energy efficiency.
Design of the service robot applied to undergraduate laboratory of pharmacy major
Authors: Zhang Dong , Guo Zhongyi
Published: January 2022

During the COVID‐19 outbreak, service robots have provided good service for teachers and students in universities. In order to improve the safety and convenience of pharmaceutical undergraduate laboratory, a service robot for pharmaceutical undergraduate teaching laboratory was designed from the aspects of path planning, positioning and navigation, human‐computer interaction etc., which can solve practical problems such as epidemic prevention and control, laboratory safety etc.
Rapid-then-slow migration reproduces mass distribution of TRAPPIST-1 system
Authors: Ogihara Masahiro , Kokubo Eiichiro , Nakano Ryuunosuke , Suzuki Takeru K.
Published: January 2022

Context. The TRAPPIST-1 system is an iconic planetary system in various aspects (e.g., habitability, resonant relation, and multiplicity) and hence has attracted considerable attention. The mass distribution of the TRAPPIST-1 planets is characterized by two features: the two inner planets are large, and the masses of the four planets in the outer orbit increase with orbital distance. The origin of these features cannot be explained by previous formation models.

Aims. We investigate whether the mass distribution of the TRAPPIST-1 system can be reproduced by a planet formation model using N-body simulations.

Methods. We used a gas disk evolution model around a low-mass star constructed by considering disk winds and followed the growth and orbital migration from planetary embryos with the isolation mass, which increases with orbital distance.

Results. As a result, we find that from the initial phase, planets in inner orbits undergo rapid orbital migration, and the coalescence growth near the inner disk edge is enhanced. This allows the inner planets to grow larger. Meanwhile, compared with the inner planets, planets in outer orbits migrate more slowly and do not frequently collide with neighboring planets. Therefore, the trend of increasing mass toward the outer orbit, called reversed mass ranking, is maintained. The final mass distribution approximately agrees with the two features of the mass distribution in the TRAPPIST-1 system.

Conclusions. We discover that the mass distribution in the TRAPPIST-1 system can be reproduced when embryos experience rapid migration and become trapped near the disk inner edge, and then more massive embryos undergo slower migration. This migration transition can be achieved naturally in a disk evolution model with disk winds.
Polyculture of tilapia (Oreochromis niloticus) and lemeduk (Barbonymus schwanenfeldii) in floating net cages as a strategy for utilizing natural food
Authors: Nurfadillah Nurfadillah , Hasri Iwan , Fahma Fahrial
Published: January 2022

Polyculture is a sustainable aquaculture system because it can reduce environmental pollution and increase feeding efficiency. The purpose of this study was to analyze the performance of growth, biomass and food competition for tilapia as the main commodity and lemeduk fish as a secondary commodity with a polyculture system in floating net cages. The research method used a Completely Randomized Design (CRD) consisting of 5 treatments and 3 replications, namely: treatment A (60 tilapia fish), Treatment B (40 tilapia fish + 20 lemeduk fish), Treatment C (30 tilapia fish + 30 lemeduk fish), Treatment D (20 tilapia fish + 40 lemeduk fish), and Treatment E (60 lemeduk fish). The research container uses floating net cages with a size of 0.5 × 0.5 × 1m. Parameters observed were absolute length growth, absolute weight growth, specific growth rate, biomass production, competition index, and water quality. The results showed that the polyculture system of tilapia and lemeduk at different stocking densities had a significant effect on absolute length growth, specific growth rate, biomass production, and had low competition between tilapia and lemeduk. The best treatment was found in treatment B (N 40+ L 20) and treatment C (N 30+ L 30) with absolute length growth value 3.20 cm±0.17, specific growth rate 3.83%±0.36, biomass of tilapia 94.36 g/0.5m2±16.45 and total biomass 100.69 g/0.5m2±5.49. Hence, the polyculture system is better than the monoculture system and the absence of competition between tilapia and lemeduk in using food.
Induction of oocyte developer hormones (oodev) on the maturity of Poropuntius tawarensis
Authors: Mellisa Siska , Hasri Iwan , Ramdayani Kasturi
Published: January 2022

Poropuntius tawarensis is an endemic fish belonging to the Cyprinidae family found in Laut Tawar Lake, Central Aceh, Indonesia. P. tawarensis has a limited distribution and the fertilization only occurs in the rainy season. The purpose of this research was to observe the effect of Oodev hormone with different doses on the maturity of P. tawarensis. This study was used completely randomized design (CRD) consisting of 3 treatments and 3 replicates. Treatments used were the hormone doses of 0.25 mL/kg, 0.50 mL/kg and treatment without hormone (control). The parameters used in this study were gonadosomatic index (GSI), egg diameter, coefficients of variation (CV) of egg diameter, fecundity, and hepatosomatic index. The study revealed the highest value found in a dose of 0.50 mL/kg which the value of egg diameter was 0.8791±0.02 mm, coefficients of variation of egg was 6.46±0.49% and fecundity was 869±33.99 egg/kg. While the highest gonadosomatic index was found in a dose of 0.25 ml/kg (10.41±2.03%). Moreover, the induction of Oocyte developer (Oodev) hormone on the maturity of P. tawarensis did not significantly affect the hepatosomatic index (HSI), but Oodev hormone was efficient to accelerate the gonad maturity of fish.
Doping nikel (Ni) metal in zeolitic imidazolate framework-8 using green synthesis method
Authors: Fajri Rahmatul , Wahyuningsih Puji , Jofrishal Jofrishal , Ediati Ratna
Published: January 2022

Ni-Doping Ni metal into ZIF-8 material aims to increase the ability of ZIF-8. Ni-ZIF-8 was synthesized using an environmentally friendly method by reusing methanol as a solvent in the previous process and carried out at room temperature. The ratio of the molar ratios used was 1:4:4 for Zinc nitrate:2methylimidazolate: TEA. As an effort to save the environment from the dangers of waste caused by the filtrate, Ni-ZIF-8 was then synthesized using the same filtrate up to six times. Based on the results of characterization using XRD, FTIR and SEM showed that the Ni-ZIF-8 material synthesized using the filtrate had similarities with Ni-ZIF-8 synthesized with pure methanol.
Estimation of the volume of production of turbine vapor of a fuel boiler with stochastic exogenous factors
Authors: Kerimkhulle Seyit , Azieva Gulmira , Saliyeva Ainur , Mukhanova Ayagoz
Published: January 2022

The paper is based on the analysis and review of the conceptual principles, methodology and practice of modelling water-steam processes of a fuel boiler of power plants; implementation of algorithms and models of the theory of system dynamics, white and pink noise; using computational technologies of difference-scheme equations and numerical integration methods, the values of the input parameters of the production of turbine vapor of the fuel boiler are determined), which, regardless of stochastic exogenous factors, provide stable states of the necessary and model volumes, norms of water intake and output of turbine vapor of the fuel boiler.

* Corresponding author: kerimkhulle@gmail.com
Biodiversity of the Indonesian marine sponge genus Aaptos with molecular networking approach
Authors: Kurnianda Viqqi , Jantama Wisha Ulung , Musman Musri
Published: January 2022

Many natural products have been isolated from the cryptic species of the Indonesian marine sponge. Despite this, it remains unclear how sponges produce such a diverse array of metabolites and their relationship to sponge diversity. During our expedition in 2017-2019, we collected the Indonesian marine sponge of the genus Aaptos, which was found surrounding Weh and Aceh Islands, the northwesternmost part of the Indonesian archipelago. All specimens were subjected to a feature-based molecular networking approach to understand their relationship. The molecular phylogenetic clades of genus Aaptos were examined by cytochrome oxide I (COI) while the presence of their chemotypes were confirmed by chemical analysis based on bioassay-guided separation with several steps of chromatography. As results, the presence Aaptos suberitoides, Aaptos aaptos, Aaptos nigra, Aaptos lobata, and Aaptos sp. were confirmed by the molecular phylogenetic. On the other hand, chemical analysis showed the presence of alkaloid-class molecules on all specimens. Interestingly, feature-based molecular networking revealed the whole figure of cryptic species were formed a clear and distinct group together with their chemotypes. Consequently, it confirmed that the relationship between the presence of each species as well as its chemotype can be distinguished clearly. In conclusion, we suspect the chemical analysis of the genus Aaptos have unknowingly conflated between different cryptic species, resulting in the seemingly idiosyncratic chemical variations.
Diversity, distribution, and species status of the fish in Banten Bay, Indonesia
Authors: Sulistiono Sulistiono , Muhamad Wildan Dudi , Ervinia Ayu , Rohim Nur , Angga Hedianto Dimas , Baihaqi Faqih , Abdillah Didit , Yoga Parawangsa I Nyoman , Wahyudewantoro Gema , Yokota Masashi
Published: January 2022

This study aims to analyze the species diversity, distribution and status of fish found in the coastal waters of Banten Bay. Samplings were carried out 7 times at three locations namely Cengkok coastal waters (on February-March 2019), Bojonegara coastal waters (January-February, August-September 2020), and Kemayungan-Linduk coastal waters (February-April 2021) of the Banten Bay, using gill nets, trammel net, cast net, hand-line, beach seine, and mini trawl. Results of this study showed that the fish caught in the Banten Bay coastal waters consisted of 111 species, distributed at the three areas, namely Cengkok (32 species), Bojonegara (58 species), and Kemayungan-Linduk coastal waters (51 species). The diversity, eveness, and dominance indices were 2.185 - 3.763, 0.630 - 0.781, and 0.072 - 0.233 respectively, indicating the medium-high species diversity. These fish were spreading in marine water, fresh water, estuary, freshwater and estuary, marine and estuary, and marine, estuary and freshwater. The common species found at the study location were Ellochelon vaigiensis, Planiliza subviridis, and Leiognathus equula. In general, most of the fish found in Banten Bay were classified as least concern (LC), while two species were vulnerable (VU), one species was near threatened (NT), and ones species was endangered species (EN).