bluuebunny/crossref_metadata_2025 huggingface dataset:
Constructing Reason
Authors: Møller Sofie
Published: September 2023

In The Architectonic of Reason, Lea Ypi provides an illuminating and innovative interpretation of the Architectonic in the first Critique. Ypi argues that Kant’s project of uniting practical and theoretical uses of reason in a critical metaphysics ultimately fails because practical reason does not have its own domain in which to legislate. This article challenges Ypi’s objection to practical reason’s lack of a domain in the first Critique. Its main contention is that reason’s need for unity in legislation may be satisfied by a belief in God as a necessary practical presupposition rather than a dogmatic metaphysical reality.
Relational Effects of Romantic Partner’s Perceived Parasocial	Romantic Attachment With Pornography
Authors: Journeay Jessica M. , Vendemia Megan A. , Forster Rebecca (Riva) Tukachinsky
Published: September 2023

Abstract: An online experiment investigated heterosexual women’s responses to their romantic partners’ pornography use. Specifically, we examined how a perceived parasocial (i.e., entirely fanciful, one-sided) versus social (i.e., reciprocal) interaction with a porn actress, as well as a perceived parasocial romantic attachment to a porn actress, may pose a relational threat to one’s actual romantic relationship. Results revealed that perceptions of infidelity and jealousy were dampened by women’s belief that their romantic partner had a weak (vs. stronger) parasocial romantic attachment to and parasocial (vs. social) interaction with a porn actress. These findings advance our understanding of the effects of pornography use within romantic relationships and highlight how parasocial relationships can affect romance.
Representing the Subgrid Surface Heterogeneity of Precipitation in a General Circulation Model
Authors: Arnold Nathan P. , Koster Randal D. , Trayanov Atanas L.
Published: September 2023

Precipitation is highly variable on spatial scales smaller than a typical general circulation model (GCM) grid box. Neglecting this subgrid‐scale variability can impact the simulation of the underlying land surface and its coupling with the atmosphere. In this study we present a scheme to stochastically disaggregate precipitation from an atmospheric grid to an underlying mosaic of surface tiles, using an assumed probability distribution of subgrid precipitation derived from observations. Unlike previous GCM‐based schemes, our approach includes a treatment of memory to allow persistence of subgrid features. In single column model experiments, we demonstrate the ability of the scheme to reproduce observed precipitation statistics at the spatial scale of the surface tiles. The root mean square error of hourly spatial standard deviation of precipitation is reduced from 1.90 to 0.96 mm hr−1 when disaggregation is applied. The scheme increases the spatial standard deviations of surface heat fluxes, soil moisture and temperature, and we show that incorporating memory amplifies these increases by a factor of 2–4. We also document increases in mean precipitation runoff and the Bowen ratio.
Winds Clear Sea Ice Through Fertile Arctic Waters
Authors: Chapman Andrew
Published: September 2023

The North Water polynya might not be as dependent on a sea ice bridge as previously thought, but not everyone is convinced.
Probing Rare Hot Plasma Flows in the Upper Atmosphere
Authors: Stanley Sarah
Published: September 2023

Postmidnight flows appear to be triggered by the same mechanism that drives more frequently observed evening flows.
A Climatological Study on the Two Types of Bow Echoes Over South China
Authors: Zhou Ang , Zhao Kun , Xu Xin , Liu Qiqing , Ding Zhicheng , Huang Hao , Liu Xiantong , Rao Xiaona , Hu Sheng
Published: September 2023

Classical bow echoes (CBEs) normally develop due to rear‐inflow jets, while merger‐formation bow echoes (MFBEs) evolve from the merger between linear systems and preline convection. MFBEs are rarely documented before, and the key processes remain unclear because of the small‐scale and fast‐evolving merging processes. Using radar observations during 2015–2019, this study examines the characteristics of these two types of bow echoes over South China. Eighteen MFBEs and 11 CBEs are identified, accounting for 62% and 38% of the total 29 bow echoes, respectively. MFBEs commonly occur over coastal regions in the afternoon, where southerly sea breezes provide favorable thermodynamic conditions. About half CBEs develop over mountainous areas in the morning, and northerly winds enhance the local baroclinity and kinematic convergence. A new Merger‐Classical index is proposed to distinguish the environments for the development of two types of bow echoes, disclosing the more favorable near‐surface thermal conditions for MFBEs. In addition, more severe weather occurs in metropolitan area near the Pearl River Delta region during MFBEs, in which the accumulated precipitation is about 2.5 times higher than that during CBEs. This study reveals the discrepancies between MFBEs and CBEs over South China, emphasizing the MFBEs account for more than half of the total bow echoes and cause more high‐impact weather in the metropolitan area. This study proposes a new perspective on the environment in which bow echo forms by merger process over South China, urging for more research to explore the underlying processes.
Optically pumped Milliwatt Whispering-Gallery microcavity laser
Authors: Li Huiqi , Wang Zhaocong , Wang Lei , Tan Yang , Chen Feng
Published: September 2023

Whispering-gallery-mode microcavity lasers possess remarkable characteristics such as high Q factors and compact geometries, making them an essential element in the evolution of microlasers. However, solid-state whispering-gallery-mode lasers have previously suffered from low output power and limited optical conversion efficiency, hindering their applications. Here, we present the achievement of milliwatt laser emissions at a wavelength of 1.06 µm from a solid-state whispering-gallery-mode laser. To accomplish this, we construct a whispering-gallery-mode microcavity (with a diameter of 30 µm) using a crystalline Nd: YAG thin film obtained through carbon-implantation enhanced etching of a Nd: YAG crystal. This microcavity laser demonstrates a maximum output power of 1.12 mW and an optical conversion efficiency of 12.4%. Moreover, our unique eccentric microcavity design enables efficient coupling of free-space pump light, facilitating integration with a waveguide. This integration allowed for single-wavelength laser emission from the waveguide, achieving an output power of 0.5 mW and an optical conversion efficiency of 6.18%. Our work opens up new possibilities for advancing solid-state whispering-gallery-mode lasers, providing a viable option for compact photonic sources.
Alk1 acts in non-endothelial VE-cadherin+ perineurial cells to maintain nerve branching during hair homeostasis
Authors: Chovatiya Gopal , Li Kefei Nina , Li Jonathan , Ghuwalewala Sangeeta , Tumbar Tudorita
Published: September 2023

Vascular endothelial (VE)-cadherin is a well-recognized endothelial cell marker. One of its interacting partners, the TGF-β receptor Alk1, is essential in endothelial cells for adult skin vasculature remodeling during hair homeostasis. Using single-cell transcriptomics, lineage tracing and gene targeting in mice, we characterize the cellular and molecular dynamics of skin VE-cadherin+ cells during hair homeostasis. We describe dynamic changes of VE-cadherin+ endothelial cells specific to blood and lymphatic vessels and uncover an atypical VE-cadherin+ cell population. The latter is not a predicted adult endovascular progenitor, but rather a non-endothelial mesenchymal perineurial cell type, which forms nerve encapsulating tubular structures that undergo remodeling during hair homeostasis. Alk1 acts in the VE-cadherin+ perineurial cells to maintain proper homeostatic nerve branching by enforcing basement membrane and extracellular matrix molecular signatures. Our work implicates the VE-cadherin/Alk1 duo, classically known as endothelial-vascular specific, in perineurial-nerve homeostasis. This has broad implications in vascular and nerve disease.
Off-axis metasurfaces for folded flat optics
Authors: Born Brandon , Lee Sung-Hoon , Song Jung-Hwan , Lee Jeong Yub , Ko Woong , Brongersma Mark L.
Published: September 2023

The overall size of an optical system is limited by the volume of the components and the internal optical path length. To reach the limits of miniaturization, it is possible to reduce both component volume and path length by combining the concepts of metasurface flat optics and folded optics. In addition to their subwavelength component thickness, metasurfaces enable bending conventional folded geometries off axis beyond the law of reflection. However, designing metasurfaces for highly off-axis illumination with visible light in combination with a high numerical aperture is non-trivial. In this case, traditional designs with gradient metasurfaces exhibit low diffraction efficiencies and require the use of deep-subwavelength, high-index, and high-aspect-ratio semiconductor nanostructures that preclude inexpensive, large-area nanofabrication. Here, we describe a design approach that enables the use of low-index (n ≈ 1.5), low-aspect ratio structures for off-axis metagratings that can redirect and focus visible light (λ = 532 nm) with near-unity efficiency. We show that fabricated optical elements offer a very large angle-of-view (110°) and lend themselves to scalable fabrication by nano-imprint lithography.
Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis
Authors: Huang Yuying , Zhu Lin , Cheng Shipeng , Dai Ranran , Huang Chunrong , Song Yanyan , Peng Bo , Li Xuezhen , Wen Jing , Gong Yi , Hu Yunqian , Qian Ling , Zhu Linyun , Zhang Fengying , Yu Li , Yi Chunyan , Gu Wangpeng , Ling Zhiyang , Ma Liyan , Tang Wei , Peng Li , Shi Guochao , Zhang Yaguang , Sun Bing
Published: September 2023

The immunomodulatory effects of ultraviolet B (UVB) radiation in human diseases have been described. Whether type 2 lung inflammation is directly affected by solar ultraviolet (UV) radiation is not fully understood. Here, we show a possible negative correlation between solar UVB radiation and asthmatic inflammation in humans and mice. UVB exposure to the eyes induces hypothalamus-pituitary activation and α-melanocyte-stimulating hormone (α-MSH) accumulation in the serum to suppress allergic airway inflammation by targeting group 2 innate lymphoid cells (ILC2) through the MC5R receptor in mice. The α-MSH/MC5R interaction limits ILC2 function through attenuation of JAK/STAT and NF-κB signaling. Consistently, we observe that the plasma α-MSH concentration is negatively correlated with the number and function of ILC2s in the peripheral blood mononuclear cells (PBMC) of patients with asthma. We provide insights into how solar UVB radiation-driven neuroendocrine α-MSH restricts ILC2-mediated lung inflammation and offer a possible strategy for controlling allergic diseases.
Voltage control of magnetism in Fe3-xGeTe2/In2Se3 van der Waals ferromagnetic/ferroelectric heterostructures
Authors: Eom Jaeun , Lee In Hak , Kee Jung Yun , Cho Minhyun , Seo Jeongdae , Suh Hoyoung , Choi Hyung-Jin , Sim Yumin , Chen Shuzhang , Chang Hye Jung , Baek Seung-Hyub , Petrovic Cedomir , Ryu Hyejin , Jang Chaun , Kim Young Duck , Yang Chan-Ho , Seong Maeng-Je , Lee Jin Hong , Park Se Young , Choi Jun Woo
Published: September 2023

We investigate the voltage control of magnetism in a van der Waals (vdW) heterostructure device consisting of two distinct vdW materials, the ferromagnetic Fe3-xGeTe2 and the ferroelectric In2Se3. It is observed that gate voltages applied to the Fe3-xGeTe2/In2Se3 heterostructure device modulate the magnetic properties of Fe3-xGeTe2 with significant decrease in coercive field for both positive and negative voltages. Raman spectroscopy on the heterostructure device shows voltage-dependent increase in the in-plane In2Se3 and Fe3-xGeTe2 lattice constants for both voltage polarities. Thus, the voltage-dependent decrease in the Fe3-xGeTe2 coercive field, regardless of the gate voltage polarity, can be attributed to the presence of in-plane tensile strain. This is supported by density functional theory calculations showing tensile-strain-induced reduction of the magnetocrystalline anisotropy, which in turn decreases the coercive field. Our results demonstrate an effective method to realize low-power voltage-controlled vdW spintronic devices utilizing the magnetoelectric effect in vdW ferromagnetic/ferroelectric heterostructures.
Evolutionary dynamics of genome size and content during the adaptive radiation of Heliconiini butterflies
Authors: Cicconardi Francesco , Milanetti Edoardo , Pinheiro de Castro Erika C. , Mazo-Vargas Anyi , Van Belleghem Steven M. , Ruggieri Angelo Alberto , Rastas Pasi , Hanly Joseph , Evans Elizabeth , Jiggins Chris D. , Owen McMillan W. , Papa Riccardo , Di Marino Daniele , Martin Arnaud , Montgomery Stephen H.
Published: September 2023

Heliconiusbutterflies, a speciose genus of Müllerian mimics, represent a classic example of an adaptive radiation that includes a range of derived dietary, life history, physiological and neural traits. However, key lineages within the genus, and across the broader Heliconiini tribe, lack genomic resources, limiting our understanding of how adaptive and neutral processes shaped genome evolution during their radiation. Here, we generate highly contiguous genome assemblies for nine Heliconiini, 29 additional reference-assembled genomes, and improve 10 existing assemblies. Altogether, we provide a dataset of annotated genomes for a total of 63 species, including 58 species within the Heliconiini tribe. We use this extensive dataset to generate a robust and dated heliconiine phylogeny, describe major patterns of introgression, explore the evolution of genome architecture, and the genomic basis of key innovations in this enigmatic group, including an assessment of the evolution of putative regulatory regions at theHeliconiusstem. Our work illustrates how the increased resolution provided by such dense genomic sampling improves our power to generate and test gene-phenotype hypotheses, and precisely characterize how genomes evolve.
Symmetry of gamma distribution data about the mean after processing with EWMA function
Authors: Hamasha Mohammad M. , Obeidat Mohammed S. , Alzoubi Khalid , Shawaheen Ghada , Mayyas Ahmad , Almomani Hesham A. , Al-Sukkar Akram , Mukkatash Adnan
Published: September 2023

Statistical Process Control (SPC) plays a vital role in maintaining quality and reducing variability in manufacturing processes. Among SPC techniques, the Exponentially Weighted Moving Average (EWMA) stands out for its ability to detect small process shifts quickly, making it a valuable tool in ensuring product consistency and preventing quality issues. EWMA constructs control charts to monitor process mean shifts, tracks product/service quality by identifying variations, and monitors manufacturing process parameters for early detection of deviations and necessary adjustments. EWMA control chart has been proposed as an alternative to the Shewhart control chart. Sequential measurements are processed using the EWMA function before being placed on the control chart. One of the crucial concerns about the EWMA control chart is the asymmetry of the data around the mean. Although processing with the EWMA function reduces data skewness, the problem of asymmetric data may not be solved. The control chart is designed to leave in front of the upper control limit (UCL) α/2 of the data and behind the lower control limit (LCL) another α/2 of the data, and this does not occur in the case of symmetric data. α/2 represents the significance level for each tail in a two-tailed hypothesis test, indicating the probability of incorrectly rejecting the null hypothesis for each side of the distribution. Since many of the distributions in real life can be approximated by the Gamma distribution, the Gamma distribution was adopted in this study. The Monte Carlo simulation methodology was implemented to generate Gamma distributed data, process it with EWMA function and assess the skewness and kurtosis. The purpose of this paper is to evaluate the effect of EWMA parameters on the performance of the EWMA control chart. Moreover, it focuses on skewness and kurtosis reduction after data processing using the EWMA function. The findings help researchers and practitioners to select the best parameters. Further, the research investigates the effect of EWMA parameter on the shape of distribution.
Exploring the clinical relevance of vital signs statistical calculations from a new-generation clinical information system
Authors: Muñoz-Bonet Juan Ignacio , Posadas-Blázquez Vicente , González-Galindo Laura , Sánchez-Zahonero Julia , Vázquez-Martínez José Luis , Castillo Andrés , Brines Juan
Published: September 2023

New information on the intensive care applications of new generation ‘high-density data clinical information systems’ (HDDCIS) is increasingly being published in the academic literature. HDDCIS avoid data loss from bedside equipment and some provide vital signs statistical calculations to promote quick and easy evaluation of patient information. Our objective was to study whether manual records of continuously monitored vital signs in the Paediatric Intensive Care Unit could be replaced by these statistical calculations. Here we conducted a prospective observational clinical study in paediatric patients with severe diabetic ketoacidosis, using a Medlinecare® HDDCIS, which collects information from bedside equipment (1 data point per parameter, every 3–5 s) and automatically provides hourly statistical calculations of the central trend and sample dispersion. These calculations were compared with manual hourly nursing records for patient heart and respiratory rates and oxygen saturation. The central tendency calculations showed identical or remarkably similar values and strong correlations with manual nursing records. The sample dispersion calculations differed from the manual references and showed weaker correlations. We concluded that vital signs calculations of central tendency can replace manual records, thereby reducing the bureaucratic burden of staff. The significant sample dispersion calculations variability revealed that automatic random measurements must be supervised by healthcare personnel, making them inefficient.
Identification of the trade-off between speed and efficiency in undulatory swimming using a bio-inspired robot
Authors: Anastasiadis Alexandros , Paez Laura , Melo Kamilo , Tytell Eric D. , Ijspeert Auke J. , Mulleners Karen
Published: September 2023

Anguilliform swimmers, like eels or lampreys, are highly efficient swimmers. Key to understanding their performances is the relationship between the body’s kinematics and resulting swimming speed and efficiency. But, we cannot prescribe kinematics to living fish, and it is challenging to measure their power consumption. Here, we characterise the swimming speed and cost of transport of a free-swimming undulatory bio-inspired robot as we vary its kinematic parameters, including joint amplitude, body wavelength, and frequency. We identify a trade-off between speed and efficiency. Speed, in terms of stride length, increases for increasing maximum tail angle, described by the newly proposed specific tail amplitude and reaches a maximum value around the specific tail amplitude of unity. Efficiency, in terms of the cost of transport, is affected by the whole-body motion. Cost of transport decreases for increasing travelling wave-like kinematics, and lower specific tail amplitudes. Our results suggest that live eels tend to choose efficiency over speed and provide insights into the key characteristics affecting undulatory swimming performance.
Lower mortality risk in APOE4 carriers with normal cognitive ageing
Authors: Pirraglia Elizabeth , Glodzik Lidia , Shao Yongzhao
Published: September 2023

Abnormal cognitive ageing, including dementia, poses serious challenges to health and social systems in ageing populations. As such, characterizing factors associated with abnormal cognitive ageing and developing needed preventive measures are of great importance. The ε4 allele of the Apolipoprotein E gene (APOE4) is a well-known genetic risk factor for late-onset Alzheimer’s disease.APOE4 carriers are also at elevated risk of cardiovascular diseases which are associated with increased risk of cognitive impairment. On the other hand,APOE4is known to be associated with reduced risk of multiple common types of cancer—a major age-related disease and leading cause of mortality. We conducted the first-ever study ofAPOE4’sopposing effects on cognitive decline and mortality using competing risk models considering two types of death—death with high-amounts versus low-amounts of autopsy-assessed Alzheimer’s neuropathology. We observed that APOE4 was associated with decreased mortality risk in people who died with low amounts of Alzheimer’s-type neuropathology, but APOE4 was associated with increased mortality risk in people who died with high amounts of Alzheimer’s-type neuropathology, a major risk factor of cognitive impairment. Possible preventive measures of abnormal cognitive ageing are also discussed.
Synthesis and applications of novel Schiff base derivatives as corrosion inhibitors and additives for improvement of reinforced concrete
Authors: Gad Ehab S. , Abbas Mohamed A. , Bedair Mahmoud A. , El-Azabawy Olfat E. , Mukhtar Shymaa M.
Published: September 2023

The studied Schiff-base compounds in this work are multitasked investigated as corrosion inhibitors and also, to improve the physical and mechanical properties of reinforced concrete. The efficiency inhibition of the two novel Schiff-base compounds named (DHSiMF) and (DHSiB) for corrosion of carbon-steel in aqueous media of 1 M HCl was assessed via electrochemical methods and loss in weight. FT-IR,1H-NMR spectra and elemental analysis were used to confirm the structure of such compounds. It was found to have successful inhibition even at low concentrations in tested media, as an increase in inhibitor concentration led to an improvement in the inhibition efficiency. The weight loss results clearly demonstrate that DHSiMF of C-steel in 1 M HCl has a higher inhibition efficiency than DHSiB, with a maximum inhibition efficiency (85%) attained at 1 × 10–2 M from DHSiMF. Electrochemical experiments likewise revealed the same order, but with a maximal inhibitory efficiency of 98.1%. The addition of inhibitors to the corrosive media dramatically changed the anodic Tafel constants (βa) and cathodic Tafel constants (βc), indicating a mixed type nature. Electrochemical polarization curves illustrated the functions of mixed-type inhibition and the action of adsorption matching with the Langmuir adsorption isotherm. The ∆Gadsvalues for DHSiMF and DHSiB at temperatures (ranging from 303 to 333 K) are − 34.42 kilojoule/mole to − 37.51 kilojoule/mole. These values indicate that the compounds’ adsorption types are chemo-physical adsorption. X-ray diffraction (XRD) and Scanning electron microscopy (SEM) experiments were used to check the existence of the protection layer on the surface of carbon steel by analyzing the morphologies of the corrosion effects and the formed chemical compositions of the corrosion outcomes. For the concrete, the findings suggest that the chemical reaction that takes place between the DHSiMF and DHSiB and the concrete mix will result in an increase in the flexural strength, the compressive strength, and the indirect tensile strength of the concrete that is made of the gravel and dolomite aggregate.
A 3–4 h oocyte retrieval-ICSI interval optimizes clinical outcomes for women over 40 years
Authors: Chen Jingbo , Wang Yanfang , Fang Cong , Li Tingting
Published: September 2023

To explore an appropriate time interval between oocyte retrieval and intracytoplasmic sperm injection (ICSI) for optimal embryological and clinical outcomes in ICSI cycles over 40 years of maternal age. A retrospective analysis of 1476 ICSI fresh cycles from women aged over 40 years, was performed at the Reproduction Medicine Research Center of the Sixth Affiliated Hospital of Sun Yat-sen University, between December 2013 and August 2020. The fertilization rate and clinical pregnancy rate were the main outcomes. Multivariate linear regression and logistic regression analysis of factors showed that fertilization rate (P = 0.024) and clinical pregnancy rate (P = 0.011) were significantly associated with oocyte pick up (OPU)-ICSI interval. A longer OPU-ICSI interval (no more than 6 h) was associated with a higher fertilization rate but significantly decreased the clinical pregnancy rate when the OPU-ICSI interval was over 4 h (P < 0.05). The optimal OPU-ICSI interval is between 3 and 4 h for excellent embryological and clinical outcomes in ICSI cycles over 40 years of maternal age.
Identification of a shared, common haplotype segregating with an SGCB c.544 T > G mutation in Indian patients affected with sarcoglycanopathy
Authors: Sanga Shamita , Chakraborty Sudipta , Bardhan Mainak , Polavarapu Kiran , Kumar Veeramani Preethish , Bhattacharya Chandrika , Nashi Saraswati , Vengalil Seena , Geetha Thenral S. , Ramprasad Vedam , Nalini Atchayaram , Basu Analabha , Acharya Moulinath
Published: September 2023

Sarcoglycanopathy is the most frequent form of autosomal recessive limb-girdle muscular dystrophies caused by mutations in SGCB gene encoding beta-sarcoglycan proteins. In this study, we describe a shared, common haplotype co-segregating in 14 sarcoglycanopathy cases from 13 unrelated families from south Indian region with the likely pathogenic homozygous mutation c.544 T > G (p.Thr182Pro) in SGCB. Haplotype was reconstructed based on 10 polymorphic markers surrounding the c.544 T > G mutation in the cases and related family members as well as 150 unrelated controls from Indian populations using PLINK1.9. We identified haplotype H1 = G, A, G, T, G, G, A, C, T, G, T at a significantly higher frequency in cases compared to related controls and unrelated control Indian population. Upon segregation analysis within the family pedigrees, H1 is observed to co-segregate with c.544 T > G in a homozygous state in all the pedigrees of cases except one indicating a probable event of founder effect. Furthermore, Identical-by-descent and inbreeding coefficient analysis revealed relatedness among 33 new pairs of seemingly unrelated individuals from sarcoglycanopathy cohort and a higher proportion of homozygous markers, thereby indicating common ancestry. Since all these patients are from the south Indian region, we suggest this region to be a primary target of mutation screening in patients diagnosed with sarcoglycanopathy.
Morphological, physical, thermal, and mechanical properties with the aspect ratio effects of bio loose-fill packaging from corn stalk
Authors: Thiraphattaraphun Linda , Prasassarakich Pattarapan
Published: September 2023

Protective packaging, such as loose-fill material, is commonly used for void filling in packages during transportation and handling. Due to environment concerns about packaging materials, alternative materials derived from agricultural residues, such as corn stalks (CS), are of attention. Dried internodal CS without rind (DCS-R) were prepared as a cylindrical-shaped bio loose-fill packaging pieces (DCS-RP) at three different aspect ratios [length/diameter (L/D) of 0.4, 0.8, and 1.2]. The morphological, physical, and thermal properties of the DCS-RP were investigated and the effect of the L/D ratio of the DCS-RP was examined under compression loading. The DCS-RP exhibited a porous structure with a low density and bulk density, while the packing efficiency at all L/D ratios was less than 1. Different compressive resistance and failure patterns of the DCS-RP were obtained, depending on the direction of compression loading (parallel and perpendicular) to the DCS-RP. In addition, the L/D ratio of bulk DCS-RP also affected the compressive resistance. The results of this study provide important information for future investigations on the protective ability of DCS-RP to the products inside the packages during transportation and handling.
Gender disparity in survival of early porcine fetuses due to altered androgen receptor or associated U2 spliceosome component
Authors: Zacanti Kelly , Park Insung , McNabb Bret R. , Urbano Tara Marie , Maga Elizabeth A. , Nitta-Oda Barbara Jean , Rowe Joan D. , Hennig Sadie L. , Ross Pablo , Berger Trish
Published: September 2023

A single locus on the X chromosome codes for androgen receptor (AR) although this gene is subject to alternative splicing. AR is expressed in multiple tissues in males and females and is essential for reproductive success in the male. Since male and female mice are viable following naturally occurring and engineered loss of function with male mice infertile as anticipated, functional deletion of AR in pigs was hypothesized to provide a genetic containment strategy for males with edited genomes. In addition, deletion of AR might be a method to manage boar taint, hence contributing to a perceived improvement in animal welfare. The CRISPR/Cas9 technology was used to edit either exon 2 or exon 5 of the pig AR gene. Although pregnancies were established following embryo transfer of edited embryos, they were not maintained beyond day 25. Furthermore, normal M:F sex ratios were present in edited blastocysts and 19-day fetuses, but all fetuses recovered on day 21 or later were female. The pig AR gene differs from the mouse in having a U2 spliceosome component encoded in the intronic region. Hence, the absence of fetal survival beyond day 25 may be due to interference with the U2 component rather than AR.
Evaluation of small hydropower turbines installed downstream of Nile River branches (Egypt)
Authors: Ahmed Mohamed E.A.E. , Abdellatif M. Attia , Attia Ahmed A. A. , Deifalla Ahmed Farouk , Elsayed Mostafa E. A. , Abdelrahman M. A.
Published: September 2023

The current study proposes a new strategy for using small hydroelectric turbines in downstream river branches with the least amount of construction and the lowest cost by comparing two different methods of installing the turbines, the first by installing the turbines at the river's bottom and the second by installing the turbines on floating boats. The methodology of this article is based on predicting the distribution of velocities through the watercourse using experimental data collected at various points in the river's depth, and then predicting the resulting electrical power for different sizes of turbines, as well as estimating the number of turbines for each row and the number of rows along the river. Therefore, Investigate the proposed systems. The proposed small hydropower system's economic viability and environmental impact are investigated in this article. According to the nature of the waterway, the best diameter of a turbine that can be used is 1.5 m based on water velocities and river depths. The proposed power plant generated 25.8 kW per single turbine row, with an estimated cost of produced power (0.035 USD/kWh) of approximately 20 turbines installed per row. Compared to other renewable energy sources, the proposed hydropower system is cost-effective and environmentally friendly, as generating electricity with the proposed small hydropower plant could reduce annual carbon dioxide emissions by 368 tones of CO2 per single turbine row.
The inhibition of pancreatic cancer progression by K-Ras-overexpressing mesenchymal stem cell-derived secretomes
Authors: Huo Qingji , Li Kexin , Sun Xun , Zhuang Adam , Minami Kazumasa , Tamari Keisuke , Ogawa Kazuhiko , Fishel Melissa L. , Li Bai-Yan , Yokota Hiroki
Published: September 2023

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival. To explore an uncharted function of K-Ras proto-oncogene, K-Ras was activated in mesenchymal stem cells (MSCs) and the effects of MSC conditioned medium (CM) on PDAC were examined. Overexpression of K-Ras elevated PI3K signaling in MSCs, and K-Ras/PI3K-activated MSC-derived CM reduced the proliferation and migration of tumor cells, as well as the growth of ex vivo freshly isolated human PDAC cultures. CM’s anti-tumor capability was additive with Gemcitabine, a commonly used chemotherapeutic drug in the treatment of PDAC. The systemic administration of CM in a mouse model suppressed the colonization of PDAC in the lung. MSC CM was enriched with Moesin (MSN), which acted as an extracellular tumor-suppressing protein by interacting with CD44. Tumor-suppressive CM was also generated by PKA-activated peripheral blood mononuclear cells. Collectively, this study demonstrated that MSC CM can be engineered to act as a tumor-suppressive agent by activating K-Ras and PI3K, and the MSN-CD44 regulatory axis is in part responsible for this potential unconventional option in the treatment of PDAC.
Combined effect of DBM, PRP, and bone marrow fluid on bone union in a rat posterolateral fusion model
Authors: Otagiri Takuma , Shiga Yasuhiro , Hozumi Takashi , Matsuura Yusuke , Tajiri Ikuko , Takayama Naoya , Alejandra Maria , Shiko Yuki , Orita Sumihisa , Inage Kazuhide , Eguchi Yawara , Suzuki Takane , Suzuki-Narita Miyako , Mukai Michiaki , Mukaihata Tomohito , Tsuchiya Ryuto , Tokeshi Soichiro , Okuyama Kohei , Arai Takahito , Toshi Noriyasu , Furuya Takeo , Maki Satoshi , Aoki Yasuchika , Ohtori Seiji
Published: September 2023

Platelet-rich plasma (PRP) promotes bone union through osteoinduction. We investigated whether adding demineralized bone matrix (DBM), derived naturally from biomaterial and with various growth factors, for osteoconductivity and bone marrow fluid for osteogenesis results in different bone unions. Eight-week-old male Sprague–Dawley rats were divided into four groups of five based on transplantation material: sham control (C group); DBM alone (D group); DBM + PRP (DP group); and DBM + PRP + bone marrow fluid (DPB group). After posterolateral fusion at L3-5, postoperative weekly CT imaging determined average number of bone union in facet joints (4 joints × 5 animals = 20 joints) and bone formation. Pathological evaluation and bone strength were assessed using 3-point bending two weeks postoperatively. Facet joint bone union at four weeks postoperatively was 4/20 (20%, DP group) and 8/20 (40%, DPB group) joints. Six weeks postoperatively, it was 7/20 (35%, D group), 12/20 (60%, DP group), and 16/20 (80%, DPB group). Eight weeks postoperatively, it was 13/20 (65%, D group), 17/20 (85%, DP group), and 20/20 (100%, DPB group), suggesting that DPB > DP > D > C. Bone formation and bone strength showed a similar DPB > DP > D > C group trend. Adding PRP and bone marrow fluid to DBM promotes bone union and strength.
The effect of seasonality and weather conditions on human perception of the urban–rural transitional landscape
Authors: Półrolniczak Marek , Kolendowicz Leszek
Published: September 2023

Landscape perception research into the impact of seasonally changing landscape characteristics with the simultaneous influence of the weather are rare. Therefore, eye-tracking metrics were calculated (fixation and saccades) for the whole tested landscape, while its areas of interest (AOIs) were established based on clustering methods. Moreover, the gaze pattern was analysed using the Voronoi cells method. To identify significant differences in landscape perception according to various weather and seasonality, nonparametric tests were applied. The significant influence of weather/seasonality and their synergistic influence is noticed. The results indicate a rather complex influence of the types of weather in warmer and cooler seasons. Regardless of the weather type, seasonal changes cause greater visual span and shorter fixations in the warmer season. The fixations and saccades are shorter in the warmer season in two AOI’s during positive weather, but are longer in negative weather during the colder season in most AOI’s. The main reasons for the influence of weather and seasonality on the visual perception include seasonal changes in the landscape, resulting in the appearance of the landscape from more urban to natural and vice versa (phenological changes) as well as lighting changes (due to seasonality and type of weather).
A comparative study of compartmental models for COVID-19 transmission in Ontario, Canada
Authors: Zhao Yuxuan , Wong Samuel W. K.
Published: September 2023

The number of confirmed COVID-19 cases reached over 1.3 million in Ontario, Canada by June 4, 2022. The continued spread of the virus underlying COVID-19 has been spurred by the emergence of variants since the initial outbreak in December, 2019. Much attention has thus been devoted to tracking and modelling the transmission of COVID-19. Compartmental models are commonly used to mimic epidemic transmission mechanisms and are easy to understand. Their performance in real-world settings, however, needs to be more thoroughly assessed. In this comparative study, we examine five compartmental models—four existing ones and an extended model that we propose—and analyze their ability to describe COVID-19 transmission in Ontario from January 2022 to June 2022.
Integrated co-expression analysis of regulatory elements (miRNA, lncRNA, and TFs) in bovine monocytes induced by Str. uberis
Authors: Sharifi Somayeh , Pakdel Abbas , Pakdel Mohammad Hossein , Tabashiri Raana , Bakhtiarizadeh Mohammad Reza , Tahmasebi Ahmad
Published: September 2023

Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), together with transcription factors, are critical pre-, co-, and post-transcriptional regulators. In addition to their criteria as ideal biomarkers, they have great potential in disease prognosis, diagnosis, and treatment of complex diseases. Investigation of regulatory mechanisms in the context of bovine mastitis, as most common and economic disease in the dairy industry, to identify elements influencing the expression of candidate genes as key regulators of the mammary immune response is not yet fully understood. Transcriptome profiles (50 RNA-Seq and 50 miRNA-Seq samples) of bovine monocytes induced by Str. uberis were used for co-expression module detection and preservation analysis using the weighted gene co-expression network analysis (WGCNA) approach. Assigned mi-, lnc-, and m-modules used to construct the integrated regulatory networks and miRNA-lncRNA-mRNA regulatory sub-networks. Remarkably, we have identified 18 miRNAs, five lncRNAs, and seven TFs as key regulators of str. uberis-induced mastitis. Most of the genes introduced here, mainly involved in immune response, inflammation, and apoptosis, were new to mastitis. These findings may help to further elucidate the underlying mechanisms of bovine mastitis, and the discovered genes may serve as signatures for early diagnosis and treatment of the disease.
On the (number of) aversive traits it takes to approximate the common core of aversive personality
Authors: Horsten Luisa K. , Moshagen Morten , Hilbig Benjamin E.
Published: September 2023

The Dark Triad and Dark Tetrad are the constellation of aversive traits that are most commonly assessed to study their common (aversive) and unique (non-aversive) features. Nonetheless, it is unclear whether these particular traits (in combination) indeed closely approximate the common core of all aversive traits. A close approximation of the aversive core, however, is crucial if one is strictly interested in an aversive trait's unique variance. Therefore, the present study aims to specify how many and which aversive traits jointly approximate the aversive core to a satisfactory extent. To this end, the aversive core was first estimated from 16 aversive traits and then correlated to the aversive cores extracted from all 63,002 possible combinations of two to eleven of these traits. Results showed that most combinations of four, or essentially any combination of at least six aversive traits, approximated the aversive core reasonably well, whereas the Dark Triad and Dark Tetrad lead to systematically poorer approximations compared to other combinations of three of four aversive traits.
Diagnostic accuracy of 18F-FP-CIT PET for clinically uncertain Parkinsonian syndrome
Authors: Oh Minyoung , Oh Seung Jun , Lee Sang Ju , Oh Jungsu S. , Chung Sun Ju , Kim Jae Seung
Published: September 2023

18F-FP-CIT is a high-resolution imaging marker of nigrostriatal neuronal integrity, differentiating Parkinsonism with loss of dopaminergic terminals (presynaptic Parkinsonian syndrome [PS]) from Parkinsonism without nigrostriatal degeneration (non-PS). We assessed the diagnostic accuracy of 18F-FP-CIT PET in patients with clinically uncertain PS (CUPS) at the first visit. Among the 272 patients who underwent 18F-FP-CIT PET imaging at the first visit between September 2008 and July 2012, 111 had CUPS (age, 62.6 ± 10.5 y; male:female, 45:66; symptom duration, 13.1 ± 8.8 months). Uncertainty criteria included only one of the three cardinal signs of Parkinsonism, two signs without bradykinesia, or atypical signs. The baseline clinical and 18F-FP-CIT PET imaging diagnostic accuracy was compared with the accuracy of clinical diagnosis after > 2-year follow-up. Nuclear medicine physicians assessed the 18F-FP-CIT PET images visually. Focal dopamine transporter binding deficit in the posterior putamen was considered PS. Bilateral symmetric striatum without focal deficit, suggesting normal 18F-FP-CIT PET, and focal deficits elsewhere in the striatum suggesting vascular Parkinsonism were considered non-PS. Seventy-nine patients had PS, and 32 did not. Baseline clinical diagnosis included PS in 45 patients, non-PS in 24, and inconclusive in 42. Among patients in whom initial clinical diagnosis (PS or non-PS) was possible, the sensitivity, specificity, and accuracy of the baseline clinical and 18F-FP-CIT PET imaging diagnoses were 54.4, 50.0, and 53.2%, and 98.7, 100, and 99.1%, respectively. The respective positive and negative predictive values were 95.6 and 66.7%, and 100 and 97.0%. Among those with initially inconclusive diagnosis, 64.2% were eventually diagnosed with PS while 35.7% were diagnosed with non-PS. The final clinical diagnosis of these patients all matched those made by 18F-FP-CIT PET imaging, except in one patient with scan without evidence of dopaminergic deficit (SWEDD). 18F-FP-CIT PET diagnosis was more accurate than clinical diagnosis, reducing the false-negative and inconclusive clinical diagnosis rates at baseline in patients with CUPS.
Exploring shared pathways and the shared biomarker ERRFI1 in Obstructive sleep apnoea and atherosclerosis using integrated bioinformatics analysis
Authors: Chen Bowen , Dong Liping , Zhang Jihua , Hao Ying , Chi Weiwei , Song Dongmei
Published: September 2023

Obstructive sleep apnea (OSA) is an upper airway disorder occurring during sleep and is associated with atherosclerosis (AS). AS is a cardiovascular disease caused by environmental and genetic factors, with a high global mortality rate. This study investigated common pathways and potential biomarkers of OSA and AS. Microarray data were downloaded from the Gene Expression Omnibus (GEO) database and used to screen for differentially expressed genes (DEGs) in the OSA and AS datasets. A weighted gene co-expression network analysis (WGCNA) was used to identify the co-expression modules of OSA and AS. The least absolute shrinkage and selection operators (LASSO) were used to determine critical biomarkers. Immune cell infiltration analysis was used to investigate the correlation between immune cell infiltration and common biomarkers of OSA and AS. Results revealed that differentially expressed genes may be involved in inflammatory processes, chemokine signaling pathways, and molecular changes in cell adhesion. ERBB receptor feedback inhibitor 1 (ERRFI1) was the best-shared biomarker for OSA and AS. Immune infiltration analysis showed that ERRFI1 expression was correlated with immune cell changes. Changes in immune pathways, inflammatory processes, and cell adhesion molecules may underlie the pathogenesis of both diseases, and ERRFI1 may be a potential diagnostic marker for patients with OSA and AS.
Simulation of GHz ultrasonic wave piezoelectric instrumentation for Fourier transform computation
Authors: Yang Zaifeng , Tan Xing Haw Marvin , Bui Viet Phuong , Png Ching Eng
Published: September 2023

The recent emerging alternative to classic numerical Fast Fourier transform (FFT) computation, based on GHz ultrasonic waves generated from and detected by piezoelectric transducers for wavefront computing (WFC), is more efficient and energy-saving. In this paper, we present comprehensive studies on the modeling and simulation methods for ultrasonic WFC computation. We validate the design of the WFC system using ray-tracing, Fresnel diffraction (FD), and the full-wave finite element method (FEM). To effectively simulate the WFC system for inputs of 1-D signals and 2-D images, we verified the design parameters and focal length of an ideal plano-concave lens using the ray-tracing method. We also compared the analytical FFT solution with our Fourier transform (FT) results from 3-D and 2-D FD and novel 2-D full wave FEM simulations of a multi-level Fresnel lens with 1-D signals and 2-D images as inputs. Unlike the previously reported WFC system which catered only for 2-D images, our proposed method also can solve the 1-D FFT effectively. We validate our proposed 2-D full wave FEM simulation method by comparing our results with the theoretical FFT and Fresnel diffraction method. The FFT results from FD and FEM agree well with the digitally computed FFT, with computational complexity reduced from $$O(N^2 logN)$$

O
(

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2

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to O(N) for 2-D FFT, and from O(NlogN) to O(N) for 1-D FFT with a large number of signal sampling points N.
Truncated vitronectin with E-cadherin enables the xeno-free derivation of human embryonic stem cells
Authors: Souralova Tereza , Hulinova Daniela , Jeseta Michal , Ventruba Pavel , Hampl Ales , Koutna Irena
Published: September 2023

Human embryonic stem cells (hESCs) have unique abilities that enable their use in cell therapy, disease modeling, and drug development. Their derivation is usually performed using a feeder layer, which is undefined and can potentially cause a contamination by xeno components, therefore there is a tendency to replace feeders with xeno-free defined substrates in recent years. Three hESC lines were successfully derived on the vitronectin with a truncated N-terminus (VTN-N) in combination with E-cadherin in xeno-free conditions for the first time, and their undifferentiated state, hESC morphology, and standard karyotypes together with their potential to differentiate into three germ layers were confirmed. These results support the conclusion that the VTN-N/E-cadherin is a suitable substrate for the xeno-free derivation of hESCs and can be used for the derivation of hESCs according to good manufacturing practices.