bluuebunny/crossref_metadata_2025 huggingface dataset:
Giant cell tumor of the tenosynovial type in the prevertebral space with a cervical approach
Authors: Rappoport Daniel A. , Fuenzalida Lucas , Sepulveda Patricio I. , Gac Patricio J.
Published: December 2021

The complex anatomy of the neck makes surgical interventions of cervical neoplasms a very complex process. The aforementioned challenges the surgeon to find a surgical approach with the least morbidity and cosmetic sequelae. This is particularly true in tumoral occupation of the prevertebral space (PVS), most frequently due to the extension of neoplasms from naso and oropharynx; whereas primary tumors of the PVS are extremely rare. There are a number of surgical approaches to access the skull base and the anterior region of the upper cervical spine, such as the transcervical-transtemporal approach, retraction and dissection of the soft palate, mandibular osteotomy, medial glossotomy, among others. The following article presents a case report in which a less invasive combined transcervical-transoral approach was performed on a tenosynovial giant cell tumor of the PVS. As an alternative in the treatment of these type of lesions, it is in our opinion equally effective and less morbid.
Evaluation of skin irritation and skin sensitization potential of Venusia max lotion (paraben-free, alcohol-free, mineral oil-free, animal origin free) using human repeat insult patch test
Authors: Gala Monil Y. N. , Muchhala Snehal S. , Charugulla Sujeet N. , Rathod Rahul , Mane Amey , Pandit Sucheta , Samal Alok R. , Choudhury Anup A.
Published: December 2021

Background: Topical exposure to chemicals from cosmetics can lead to adverse skin effects or skin irritation. This study aimed to investigate the skin irritation and sensitizing potential of a moisturizer Venusia max lotion (paraben-free, alcohol-free, mineral oil-free, animal origin free (PAMA) free).

Methods: In this single-center, non-randomized, observational study, skin irritation, and skin sensitization potential of a test product was assessed using the human repeat insult patch test (HRIPT) technique. Approximately 0.04 g of the test product and filter papers dipped in 0.9% isotonic saline solution (~0.04 ml of solution) were filled in different wells of patch chambers and applied occlusively, on the back of each participant. Scoring of the skin reactions in the induction phase and challenge phase was done using Draize and international contact dermatitis research group (ICDRG) scales respectively. Scores were compared to the baseline and the negative control (isotonic saline).

Results: In total 234 participants (50 with sensitive skin), 224 and 221 participants completed the induction phase and challenge phase respectively. Scores for the induction phase for Venusia max lotion (PAMA free) and isotonic saline were 0.46 and 0.06 respectively. The mean cumulative score of erythema and oedema for Venusia max lotion (PAMA free) was below 2. For the challenge phase, none of the participants showed any positive reactions at any time point for test product and isotonic saline.

Conclusions: Test product Venusia max lotion (PAMA free) found to be non-irritant and hypoallergenic. Thus, it can be used without fear of skin irritation or sensitization.
An approach to treatment modalities of keloids: a comparative study
Authors: Parmar Sweta S. , Modi Avani
Published: December 2021

Background: In spite of the presence of such an array of treatment modalities, none of these can be claimed to be an ideal treatment option as most of them have limited efficacy, significant side effects or increased chances of recurrence. Hence the study was undertaken to search an ideal treatment for keloids which is safe, effective, and with low rate of recurrence.

Methods: Total of 200 patients were recruited out of which only 160 patients were included in study. The patients were divided into three groups and administered with different modes of treatment. Patients in all the groups were followed up at 3 weekly intervals for evaluation of response. At the end of the study, the data was compiled and analysed using appropriate statistical tests.

Results: In only 32 patients completed study in group 1, 2 and 3 respectively. Group 1, 2 and 3 were more or less equally efficacious with clearance rate. Complete clearance was seen in 24 patients in group 1 patients, in group 2 there were 22 patients with complete clearance and in group 3 there were 24 patients.

Conclusions: Intralesional triamcinolone acetonide, intralesional triamcinolone acetonide with hyaluronidase and intralesional radiofrequency with intralesional triamcinolone acetonide are almost equally effective modalities for the treatment of keloids. But, intralesional triamcinolone acetonide with hyaluronidase fares better than other two as far as safety is concerned with least side effects.

 
Micro needling vs micro needling combined with autologous topical platelet rich plasma in the treatment of melasma: a prospective randomized comparative study
Authors: Panda Anil Kumar , Jena Ajaya Kumar , Panda Maitreyee , Raj Chinmoy , Debata Ipsita
Published: December 2021

Background: Melasma is one of the most common pigmentary disorders worldwide with a still unresolved pathogenesis and treatment continues to be challenging. To assess the effect of micro-needling vs combination of micro-needling followed by application of topical platelet rich plasma (PRP) in the treatment of melasma.

Methods: Sixty patients having melasma were randomly grouped into A and B. Group A underwent micro-needling alone and group B was subjected to micro-needling followed by topical application of autologous PRP. The patients were subjected to 3 treatment sessions at monthly intervals. Melasma area and severity index (MASI) and patient satisfaction scores were recorded at each sitting and the final outcome was recorded one month after the last session.

Results: Twenty-four patients in group A and 27 patients from group B were selected for final analysis. There was significant improvement of MASI in both groups (Group A: p=0.001, group B: p=0.0001) however, the difference in improvement of MASI between the 2 groups was not significant (p=0.0457) Group B was highly satisfied with the treatment which was statistically significant (p=0.0001)

Conclusions: Combining micro-needling with topical PRP appears to be a promising therapeutic modality in the treatment of melasma.

 
Efficacy and safety of iontophoresis combined sodium salicylate in acquired plantar keratoderma-a randomized controlled study
Authors: Somani Shreya P. , Astik Bhavsh N. , Mehta Hita H. , Jhavar Milan D.
Published: December 2021

Background: Palmoplantar keratoderma is a heterogenous group of disorders, hereditary or acquired, characterized by thickening of palms and soles. Though it is not a life-threatening condition, it affects individual’s quality of life. As treatment of keratoderma has always been troublesome, upgraded treatment modalities which improves keratoderma efficiently are always encouraged.

Methods: In this randomized controlled study, patients of plantar keratoderma of age group of 18-65 years were randomly divided in group A and group B. In group A, iontophoresis combined sodium salicylate was offered to patients twice weekly for 8 weeks of duration, during which DC current was supplied at 5-15 mA for 10 min of duration. Whereas, in group B patients applied topical salicylic acid 12% ointment at home twice a day for 8 weeks.

Results: Our study of 70 patients of keratoderma, revealed diffuse (94%) pattern of involvement with female preponderance (55.7%) and occupation wise, most common among laborers (54.2%) followed by housewives (27.1%). Statistically significant number of patients showed reduction in severity grading of parameters, in both groups at end of 8 weeks. Same way, mean values of parameter grading significantly reduced at 8 weeks in both the groups. But intergroup values showed no significant difference. Mean EASI (Eczema Area Severity Index) score showed statistically significant reduction in group B as compared to group A at 8th week. Percentage of reduction of EASI score was also significantly higher in group B at end of treatment.

Conclusions: Here both treatment modalities are safe and effective, topical being slightly more efficacious than iontophoresis. So, we can conclude that no additional privilege of drug delivery through iontophoresis.
Platelet-rich plasma in the treatment of alopecia
Authors: Rizvi Safi Abbas
Published: December 2021

Platelet rich plasma (PRP) is a promising treatment choice for patients with thinning hair. Despite excellent clinical safety and low cost, its clinical standing is still weak. The effectiveness of this method depends on its dosage, number of sessions, their intervals and technique of injection incorporated. PRP can produce particularly some phenomenal effects when applied in cosmetic dermatology. The therapeutic value of PRP is equivalent to stem cells and considered as one of the promising therapeutic agents in regenerative medicine. Harvesting of PRP plays a significant role, which is obtained from the patient's blood after centrifugation of the sample i.e., the platelet concentrates above the baseline which is the plasma fraction of the autologous blood. There are many applications of PRP in the medical field and has an incredibly significant role in dermatologic conditions e.g., tissue regeneration, wound healing, scar revision, skin rejuvenation and alopecia. In this review, we will be analyzing the authenticity of the use of PRP in the treatment of alopecia. PRP, in current scenario, is considered as a novel treatment modality. The efficacy of PRP therapy carries some deficiencies, which include lacking standard in preparation and concentration of platelets in PRP.

 
Expert opinion on current trends in hyperpigmentation management: Indian perspective
Authors: Kandhari Sanjeev , Rao P. Narasimha , Arsiwala Shehnaz , Ganjoo Anil , Sood Seema , Kumar Dinesh
Published: December 2021

Hyperpigmentation is a common pigmentary disorder characterized by increased production of melanin. It is present in Asian skin phototypes, with a higher prevalence in the Indian population. Skin heterogeneity is seen in more than 80% of individuals of all age groups and genders in several cities across India. In children, the prevalence of hyperpigmentary disorders accounts for 1.54 per 1000 children.Sixty expert dermatologists participated in expert group meetings via teleconference webinar to elaborate on the current trends in the management of hyperpigmentary disorders. The major reasons for hyperpigmentary disorders in India include melanocyte function followed by exposure to ultraviolet radiation, race, ethnicity, use of medications, pregnancy, and use of cosmetic. There are wide varieties of skin-lightening or depigmenting agents and skin resurfacing procedures that aid in the management of hyperpigmentation. However, treatment becomes challenging due to compliance issues related to affordability, complexity of prescriptions, and treatment duration. Compliance increases only if the patient sees any improvement or discontinues treatment due to higher expectations. Hence, the success of the treatment lies in patient adherence. This article summarizes expert opinions on identifying, diagnosing, and managing hyperpigmentation with the help of topical depigmenting agents in the Indian scenario. It also emphasizes treatment adherence issues along with the role of patient counseling and education regarding disease awareness and treatment strategies.
Pramoxine containing topical formulation of eberconazole in the management of dermatophytosis in India: a consensus statement
Authors: Khopkar Uday , Barua Shyamanta , Rathi Sanjay Kumar , Tiwari A. N. , Nikam Balakrishna , Nayek Chitra , Shah Hemen , Srinivas H. M. , Kest Praneetha , Prasad P. V. S. , Katariya Rajesh , Pillai Rathish , Mahajan Satyaprakash , Mishra Saurabh K. , Umar Yaseen , Gala Monil Yogesh Neena , Muchhala Snehal Sameer
Published: December 2021

Dermatophytosis, a superficial fungal infection has attained significant extents among Indian population. Its clinical presentation is diverse, often in terms of morphology, severity type and involvement of all age groups. Management of dermatophytosis has become an important public health issue in India. Cases of steroid modified dermatophytosis are being encountered frequently, mostly caused due to the inadvertent use of steroid in combination with topical antifungal agents. This combination is available over the counter and is often used for the management of inflammation and pruritis associated with the disease. Current treatment recommendations must be reviewed as per the current clinical scenario of the disease. Thus, a topical formulation of an anti-itch agent like pramoxine and antifungal agent with an anti-inflammatory property like eberconazole holds a promising treatment approach for dermatophytosis. This article focuses on the challenges encountered in the management of dermatophytosis and strategies for optimizing treatment for better patient outcomes. An expert’s panel discussion was conducted involving fifteen dermatologists all over India, during which modified Delphi method was executed for a set of nine statements. Agreement of more than 75% was set to reach the consensus. This consensus document was developed to review the available evidence and make recommendation based on the expert group’s opinion for the use of pramoxine containing topical formulation of eberconazole, as it provides the benefit of having an anti-inflammatory and anti-pruritic activity in a single formulation, where pramoxine can be utilised as an excipient to combat pruritis associated with dermatophytosis.

 
Anxiety and depression in post-Menopausal women: A short review
Authors: Acharya Neema , Madaan Sparsh , Jaiswal Arpita , Dewani Deepika , Kotdawala Kanan
Published: December 2021

Anxiety, Depression and stress are one of the most prevalent psychological problems witnessed in post-menopausal women. These complaints are mostly neglected by the females and ignored due to social stigmas and lack of awareness amongst the elderly population regarding the same. It often affects the quality of life and is thus essential to diagnose and treat on time. Reduced Vitamin D and estrogen levels are one of the proposed culprits behind these psychological disorders in post-menopausal women which will be discussed in this review.

Systematic literature review was done with the help of data search domains such as Pubmed, Scopus, Web of science and google scholar. Case reports, observational studies and cross-sectional studies were included in this review.

Depression and anxiety are common problems for the post-menopausal women. Various factors such as reduced Vitamin D levels and Estrogen levels as well as increased stress can contribute to development of these psychological complaints. Though these problems might look benign to the patients, they can severely impact the mental health and require more awareness amongst the patients to improve the mental as well as physical health in post-menopausal women.

Women in the post-menopausal stage have increased predisposition towards developing psychological disorders and hence the assessment of mental health is essential in these females which should be a vital part of the evaluation done of these females.
The role of humour and laughter therapy in decreasing caregiver burden among carers of a person living with dementia- A case study
Authors: Desai Sachin
Published: December 2021

Gibbs (1988) reflective cycle was employed to explore a critical case study involving a senior citizen with dementia and measures to reduce caregiver burden by humour and laughter therapy. This experience highlights key themes of caregiver burden-reduction measures through humour and laughter. This problem is discussed in relation to lack of awareness about measures to reduce caregiver burden arising due to caretaking of a person with dementia. Inclusion of this therapy as a non-pharmacological method of stress management, could be useful in the guidelines for dementia care. Therefore, it is important to include training to all caregivers at home and care home setting to address the issue of caregiver burden.
Effect of miR-184 and miR-205 on the tumorigenesis of conjunctival mucosa associated lymphoid tissue lymphoma through regulating RasL10B and TNFAIP8
Authors:   Department of Ophthalmology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China, Li Yu-Zhen , Shen Ya ,   Department of Ophthalmology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China, Gao Lian-Di ,   Department of Nursing, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China, Chen Xin-Xin ,   Department of Ophthalmology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China, Wei Rui-Li ,   Department of Ophthalmology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China
Published: December 2021

AIM: To explore the effect of miR-184 and miR-205 on the proliferation and metastasis of conjunctival mucosa associated lymphoid tissue (MALT) lymphoma.
METHODS: Tissue of tumor and adjacent normal control from 5 patients with conjunctival MALT was included. RPMI8226 cell line was selected to verify the effect of miRNAs in B cells. The function of microRNA on the RPMI8226 cell apoptosis, migration and invasion was evaluated by apoptosis assay and Transwell assay. The mRNA and protein expression were examined by quantitative RT-PCR and Western blotting. The effect of microRNA on regulation of downstream gene expression was evaluated by luciferase report assay.
RESULTS: A decreased level of miR-184 and miR-205 was observed in MALT lymphoma tissue. Exogenous miR-184 and miR-205 analogues promoted apoptosis, and inhibited the survival, migration, and invasion of RPMI8226 cells. miR-184 and miR-205 inhibitor reversed the process. The RNA and protein level of RasL10B and TNFAIP8 were downregulated in MALT lymphoma tissue. The exogenous of miR-184 and miR-205 promoted the expression of RasL10B and TNFAIP8. Meanwhile, inhibition of miR-184 and miR-205 repressed the expression of target gene, RasL10B and TNFAIP8.
CONCLUSION: miR-184 and miR-205 suppresses the tumorigenesis of conjunctival MALT lymphoma through regulating RasL10B and TNFAIP8.
Vitreous microparticles contain apoptotic signals suggesting a diabetic vitreopathy
Authors:   John Hardesty Department of Ophthalmology, Washington University, St. Louis, MO 63110, USA, Sultan Harris , Rao Prabakar Kumar ,   John Hardesty Department of Ophthalmology, Washington University, St. Louis, MO 63110, USA, Piggott Kisha Deslee ,   John Hardesty Department of Ophthalmology, Washington University, St. Louis, MO 63110, USA, Paley Michael A ,   Department of Medicine, Division of Rheumatology, Washington University, St. Louis, MO 63110, USA, Hassman Lynn Marisa ,   John Hardesty Department of Ophthalmology, Washington University, St. Louis, MO 63110, USA, Li Albert S. ,   Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA, Marshall Brigid ,   John Hardesty Department of Ophthalmology, Washington University, St. Louis, MO 63110, USA, Apte Rajendra Shridhar ,   John Hardesty Department of Ophthalmology, Washington University, St. Louis, MO 63110, USA
Published: December 2021

AIM: To evaluate differences in microparticle profiles in vitreous samples between diabetic and non-diabetic eyes undergoing vitrectomy.
METHODS: Un-masked cross-sectional series of 34 eyes undergoing vitrectomy. Vitreous specimens were collected and processed to evaluate for membrane integrity (DAPI), apoptosis (Annexin-V), and endothelial-cell origin (V-Cadherin). A BD LSR II flow cytometer was used for analysis and standardized sub-micron-sized beads were used for size comparison.
RESULTS: Thirty-four specimens underwent analysis. Greater levels of Annexin-V were found on microparticles from specimens in which blood had entered the vitreous (n=12) compared to those without blood (n=22; 52.3%±30.7% vs 19.6%±27.2%, P=0.002). Patients with diabetes having surgery with hemorrhage (n=7) had greater expression of Annexin-V than those without hemorrhage (n=8; 62.1%±31.7% vs 18.9%±20.9%, P=0.009). However, in patients with non-diabetic vitreous hemorrhage, the level of Annexin-V expression was not significantly different compared to other disease processes (38.6%±25.7%, n=5 vs 20.0%±30.9%, n=14, P=0.087).
CONCLUSION: Increased expression of the apoptotic marker, Annexin-V is detected on vitreous microparticles in diabetes-related vitreous hemorrhage. When evaluating vitreous hemorrhage in patients without diabetes, the apoptotic signal is not significantly different. Vitrectomy in patients with diabetes, and improvement in visual outcomes, may be related to the removal of a serum-derived, pro-apoptotic vitreous. Further investigation is warranted in order to identify the molecular characteristics of microparticles that regulate disease.
Relações Entre Apego do Pai, Envolvimento Paterno e Abertura ao Mundo
Authors: Backes Mariana Schubert , Bolze Simone Dill Azeredo , Vieira Mauro Luís , Crepaldi Maria Aparecida
Published: December 2021

Este estudo investigou a relação entre o apego do pai, o envolvimento paterno e a abertura ao mundo, na perspectiva do pai de crianças. Participaram do estudo 171 pais de crianças entre 4 e 6 anos de idade. Os instrumentos utilizados foram: Escala de Apego Adulto (EAA), Questionário de Engajamento Paterno (QEP), Questionário de Abertura ao Mundo (QOM). A análise dos dados mostrou que os pais com apego seguro se envolvem de forma predominante em atividades de estímulo ao risco e se dedicam nos cuidados básicos com a criança, do que os pais com apego inseguro, e essa diferença mostrou-se estatisticamente significativa. Evidenciou-se que os pais que desenvolveram um apego seguro sentem-se mais confiantes para incentivar seus filhos a explorarem o ambiente e desenvolverem atividades desafiadoras, lhes dando segurança e promovendo sua autonomia e, também, se consideram preparados para cuidar da criança, alimentando-a, dando banho, levando-a à escola, entre outras atividades.
Interação Mãe-Bebê no Ambiente Prisional
Authors: Dos Santos Catia Bibiano , De Sezaro Jéssica , Portes João Rodrigo Maciel , Bossardi Carina Nunes
Published: December 2021

A penitenciária é um contexto atípico para o desenvolvimento infantil, portanto é possível que as interações entre a díade mãe-bebê sofram interferências das características desse ambiente. Com objetivo de identificar e compreender as interações entre bebês e mães encarceradas, essa pesquisa contou com o uso da metodologia observacional. Após o levantamento de dados sociodemográficos, foram observadas as interações entre mães e bebês no contexto carcerário, durante 20 minutos em três dias diferentes. Observou-se quatro díades mãe-bebês. As crianças tinham entre zero a sete meses de idade. As interações foram gravadas em áudio e vídeo e analisadas com base em um protocolo de categorias previamente estabelecidas, conforme a literatura. Os comportamentos da mãe, com maior frequência, foram olhar e embalar, enquanto que os dos bebês foram vocalizar e ficar irrequieto. Tais resultados evidenciam um compartilhamento recíproco de atenção e afeto entre as díades. Contudo, observa-se a ausência de comportamentos de interação essenciais para o desenvolvimento na primeira infância, como a estimulação por objetos. Indica-se a necessidade de atividades de orientação sobre as formas de promoção de desenvolvimento saudável.
Observação On-line das Interações Familiares: Considerações para a Pesquisa
Authors: Palazzi Ambra , Schmidt Beatriz , Piccinini Cesar Augusto
Published: December 2021

A pandemia do novo coronavírus (COVID-19) tem gerado profundos impactos na sociedade, afetando a saúde física e mental dos indivíduos e as interações familiares. Na realização de pesquisas envolvendo famílias, tecnologias da informação e da comunicação (TICs) vêm sendo implementadas com o intuito de compreender as dinâmicas relacionais durante a pandemia e garantir a continuidade de estudos iniciados anteriormente. O objetivo deste estudo é apresentar possíveis adaptações, para a modalidade on-line, dos procedimentos de coleta de dados em pesquisas envolvendo observação das interações familiares. Trata-se de um artigo metodológico, em que são discutidas as potencialidades da observação on-line, como a maior abrangência geográfica e validade ecológica, mas também os desafios, como a dificuldade de padronizar os procedimentos de coleta de dados, por conta da variabilidade na qualidade dos equipamentos e da conexão de Internet. São destacados aspectos técnicos para auxiliar pesquisadores na seleção de equipamentos de áudio/vídeo e plataformas de videoconferência, bem como no planejamento e na realização da coleta de dados. A observação on-line pode favorecer a compreensão da complexidade das dinâmicas familiares durante o distanciamento social e, também, após a pandemia, caracterizando-se como uma estratégia de pesquisa eficaz para o estudo de famílias em diferentes contextos.
A SIFT Description Approach for Non-Uniform Illumination and Other Invariants
Authors: Boonsivanon Krittachai , Sa-Ngiamvibool Worawat
Published: December 2021

The new improvement keypoint description technique of image-based recognition for rotation, viewpoint and non-uniform illumination situations is presented. The technique is relatively simple based on two procedures, i.e., the keypoint detection and the keypoint description procedure. The keypoint detection procedure is based on the SIFT approach, Top-Hat filtering, morphological operations and average filtering approach. Where this keypoint detection procedure can segment the targets from uneven illumination particle images. While the keypoint description procedures are described and implemented using the Hu moment invariants. Where the central moments are being unchanged under image translations. The sensitivity, accuracy and precision rate of data sets were evaluated and compared. The data set are provided by color image database with variants uniform and non-uniform illumination, viewpoint and rotation changes. The evaluative results show that the approach is superior to the other SIFTs in terms of uniform illumination, non-uniform illumination and other situations. Additionally, the paper demonstrates the high sensitivity of 100%, high accuracy of 83.33% and high precision rate of 80.00%. Comparisons to other SIFT approaches are also included.
Consumer Conformity, Social Ties and EWOM in Digital Marketing
Authors: Badawi Badawi , Nurudin Arif , Muafi Muafi
Published: December 2021

Digital marketing is a marketing technique that is widely discussed in the latest literature. The complexity of digital marketing creates new variables in an effort to increase purchase intention, such as consumer conformity, social ties and EWOM (Electronic Word of Mouth). This study aims to analyze the relationship between consumer conformity, social ties, and EWOM in digital marketing on the Shopee, Lazada, and Bukalapak platforms. Through quantitative methods using Structural Equation Modeling (SEM) analysis using AMOS software on 200 respondents consisting of users of the Shopee, Lazada, and Bukalapak platforms. This study analyzes 5 hypotheses, which is then statistically proven to have a significance value of < 0.05, which means that there is a significant relationship between the variables, thus all hypotheses are supported. The results indicate that social ties and EWOM can have a significant effect on consumer conformity and are also able to directly affect purchase intention. This research also highlights that consumer conformity has a significant effect on purchase intention in digital marketing.
Development of an educational resource for studying the graphic editor Adobe Photoshop
Authors: Hrabust Sofia , Markovets Оlexander , Klynina Тetiana
Published: December 2021

The paper analyzes the most popular Internet resources for educational services. Particular attention is paid to the study of the web platform Moodle, which was used to develop an educational resource for learning the graphic editor Adobe Photoshop. The advantages and disadvantages of this platform are established. Based on the analyzed web platform, documentation of the educational web resource was provided, as well as steps to develop the web resource using the Moodle web platform. With the help of the goal tree, the main tasks in creating an educational resource are identified. Information and functional models of the educational web resource are built, which will help to determine the stages of its development and filling with educational materials. The optimal structure of the course for studying the graphic editor Adobe Photoshop is offered and the prospects of introduction of the educational web resource are given
Organizing Access to Archival Documents under COVID-19: Experience of Ukrainian Archival Institutions
Authors: Sverdlyk Zoriana
Published: December 2021

The article, based on legislative acts and normative legal documents, considers the issues of organizing access to archive documents by archive institutions in the conditions of spread on the territory of Ukraine of respiratory disease COVID-19. Immediately after the reports of the spread of the infection appeared, the archival institutions had to orient themselves quickly and develop a strategy for further action, without violating the adopted laws and acting within the orders issued by the central government. Given the recent increase in interest in information from archival documents among researchers, scholars and parties involved, an important task for archivists was to arrange access to archival documents under quarantine restrictions. Therefore, it is important to analyze the specific steps taken by the management and staff of archives, as well as research institutions subordinated to the State Archival Service of Ukraine to ensure researchers’ access to archival documents without harm to their health and life. The present paper demonstrated the network of archive institutions of Ukraine and information about their work on providing users with access to the documents of National Archival Fund under conditions of restricted operation of reading rooms. It also analyzed the content of the orders adopted by the State Archival Service of Ukraine on counteracting the spread of coronavirus disease on the territory of archival institutions of Ukraine. Key areas were identified in the provision of access to archival documents on condition of complete shutdown of reading rooms. The authors evidenced an increase in online activity of archivists in the way of placing copies of archival documents, fund descriptions for use by the research community
Cultural and Educational Activities of Social Memory Institutions on the Internet in Modern Conditions
Authors: Paskal Zhanna
Published: December 2021

The article, based on the analyzed information from official sources, examines the cultural and educational activities of museums, archives, and libraries of Ukraine during the application of quarantine measures associated with the COVID-19 pandemic. Attention is focused on informational, educational, scientific activities implemented by institutions of social memory through official websites, social networks, online communication software. It was found that the work of the Khanenko Museum and the Museum of Arts selected for analysis has largely moved to the Internet, but was characterized by activity, novelty, and significant informational content. The museums developed interactive master classes for children, various educational and informative presentations, online exhibitions, and lectures. At the same time, the activities of the investigated archival institutions (H. Pshenychnyi Central State CinePhotoPhono Archives of Ukraine and State Archives of Mykolaiv region), with the onset of quarantine restrictions focused primarily on the rapid expansion of access to archival materials by increasing their digitization and placement on official websites. The degree of adaptability of libraries (Yaroslav the Wise National Library of Ukraine and V. Korolenko Kharkiv State archival institutions Scientific Library) to the new conditions was also considered and it was found that the latter organized the work on providing users with the necessary materials well enough. During the study, methods of comparison, synthesis and analysis, retrospective and statistical were used. The key areas in the cultural and educational activities of the institutions under study are highlighted
Creating an innovative climate as a prerequisite for innovation management in the library
Authors: Bilovus Lesia , Vasylkiv Olena
Published: December 2021

The article raises issues related to the creation of an innovative climate as an important prerequisite for managing innovations in the library. The processes taking place in modern society make librarians constantly search for new ideas, forms, tools and methods of work, management actions, and analysis of their activities. The specificity of innovations is that they always contain a new solution relevant to an urgent problem and allow getting results that have innovative content.Innovation in librarianship is the creation of fundamentally new patterns of activity that go beyond unregulated norms and bring professional activity to a fundamentally new qualitative level.
The problem of actualization of historical memory in the context of the political influence of the regionalelites of Sumy region
Authors: Bevz Tetiana
Published: December 2021

The article analyzes the role of regional political elites of Sumy region in the actualization of historical memory. It was noted that the politics of memory is a symbolic resource of regional political elites. It was shown that regional political elites, on the one hand, «can create a favorable ground for the growth of multiple identities», and on the other – «are able to stimulate the growth of polar and conflicting identities». Emphasis was placed on the fact that the historical past becomes the ideological present. It was shown that the basic factor for the regional political elite of Sumy region in the processes of actualization of historical memory was the symbolic representation of the past, first of all, the history of the region. It was determined that memory is designed not only to reflect the past, but also to form its meaning for the present. In today's world, there is a great public demand for the formation, restoration, preservation, transmission, reading and affirmation of historical memory. And in this context, the urgent need for the central government and the regional political elite was the need to actively shape a nationwide policy of historical memory.
Modern PR technologies and institutions of social memory: practice of use
Authors: Klynina Tetiana , Мarkovets Oleksandr
Published: December 2021

The paper analyzes the most popular technologies used in public relations to build an image. Particular attention is paid to the functions and goals of PR, the most used tools in PR are revealed, as well as the advantages and disadvantages of each of them. For convenience, PR technologies have been divided into two major groups: those used on the Internet and the so-called “offline” technologies.The essence of the concept of social memory institutions was clarified and on the basis of research of libraries, museums and archival institutions a sample was made about PR technologies used in their activities by social memory institutions. As a result of the analysis, a conclusion was made about the limited set of PR tools used by libraries, museums and archival institutions and suggested ways to solve this problem.
Concept of a document and documents’ transformation as technology changes
Authors: Kontrimavičienė Danutė
Published: December 2021

The end of the 20th century marked the beginning of the document digitalisation process which caused various discussions among professionals regarding the concept of documentation and the main differences between physical medium and digital medium. Some concerns were raised regarding the lack of ability to identify the integrity, immutability and authenticity of such documents – the three qualities integral for any document. Analogue documents (written, photographic or audiovisual documents) are inseparable from the medium, then their authenticity and originality can always be verified by technical means. Thus, the question of how digital born documents should be handled and whether the lack of processes to identify the validity of such document makes them automatically not integral, immutable, and authentic remains. While digital documents are simple to transfer and easy to reproduce, they are difficult to authenticate and might cause difficulty to view and use in the future.
Lithuanian State Archives – 100
Authors: Gudelis Darius , Baranauskaitė Milda , Mozūras Dovydas , Kontrimavičienė Danutė
Published: December 2021

The Lithuanian state archives are commemorating their 100th anniversary this year. Historically, the origins of the documentary heritage of the Lithuanian state can be traced back to the time of the Grand Duchy of Lithuania. Throughout history, despite changes in the system of state archives, their main function and purpose have not changed. They continue to treasure and preserve the state's documentary heritage. Over the course of 100 years, the structure and subordination of the state archives have changed several times, documents moving from one premise to another, technologies regarding document storage constantly improving. The Lithuanian state archives were officially established on October 19th, 1921, when the Minister of Education of the Republic of Lithuania approved the Statute of the Central State Archive and appointed its director. This statute stated that the archive should preserve all existing state and municipal documents acquired before the establishment of the Republic of Lithuania. It must also maintain the liquidated and non-essential documents of these organizations and collect documents of state, public and scientific value from private people and public organizations.
ŞEYH MÜFÎD’İN EBÛ TÂLİB’İN DİNÎ KONUMUNA DAİR GÖRÜŞLERİ
Authors: BULUT Halil İbrahim , KÜLLÜ Cebrail
Published: December 2021

Bu makalede, İmâmiyye Şîası’nın önemli âlimlerinden biri olan, İmâmiyye kelâmına aklı dâhil eden ve Usûlî geleneği başlatan Şeyh Müfîd’in Îmânu Ebî Tâlib adlı eseri bağlamında –mezhepler arası bir tartışma konusu olan- Ebû Tâlib’in dinî konumu ele alınmıştır. İlk olarak söz konusu risalenin müellifi olan Şeyh Müfîd’in hayatı, ilmî şahsiyeti ve eserleri hakkında bilgi verilmiştir. İkinci olarak çalışmanın ana konusunu oluşturan Ebû Tâlib’in hayatı ve kişiliğine yer verilmiştir. Çalışmanın son bölümünde ise, siyasî çekişmelerin bir vasıtası olarak ortaya çıkan ve hakkında birçok eserin yazılmasına sebep olan Ebû Tâlib’in imanı meselesi ele alınmıştır. Makalenin boyutlarını aşacağından karşıt görüş sahiplerinin delillerine yer verilmemiş; sadece Şeyh Müfîd’in ilgili eseri bağlamında Ebû Tâlib’in iman üzere öldüğünü iddia edenlerin delillerine yer verilmiştir.
Разработка методов лечения ожоговой болезни III степени у животных (экспериментальная часть)
Authors: Мельников В.В. , Концевая С.Ю.
Published: December 2021

Применение секретома мультипотентных мезенхимальных стромальных клеток (ММСК), в результате проведённых доклинических испытаний, показало статистически достоверный терапевтически значимый эффект в лечении ожоговых ран III степени у лабораторных животных (крыс), в сравнении с традиционной терапией (мазь Левомеколь).
CD16A and CD16B mRNA levels as a potential immunological marker in prostate cancer
Authors: Arioua Khalil
Published: December 2021

Introduction and purpose Understanding the movement of immune cells in prostate cancer is the best solution for development antitumor therapy. In our study, we will evaluate level mRNA CD16А (FCGR3A) and mRNA CD16B (FCGR3B) in patients diagnosing benign hyperplasia and patients diagnosing prostate cancer (Pc). Materials and methods In the study, we analyzed 240 samples of mRNA, 49 was the blood of healthy donors, 37 was the blood of prostate cancer patients and 62 tumors of prostate, 37 were blood of hyperplasia and 55 was tissue of hyperplasia, all patients treated in the Hospital 33 (Niznhy Novgord, Russia). The relative level of mRNA in peripheral blood and tumors was determined by the method of reverse transcription-polymerase chain reaction in real time. Results In the peripheral blood of patients with prostate cancer and patients with hyperplasia, the level of mRNA FCGR3A and FCGR3B was statistically significantly lower than in healthy individuals. The normalization of the CD16 level in the blood of healthy donors was higher The relative level of mRNA FCGR3A, FCGR3B was the highest in patients with Prostate antigen specific (PSA) from 10Ng/ml to 20Ng/ml. The higher level mRNA FCGR3A and FCGR3B was for patients with higher testosterone ≥8mmol/L. also a higher level of FCGR3A, FCGR3B was found in patients diagnosed with an adenopathy:, a higher size prostate and a higher Gleason Scores. The results of Classification based on the degree of differentiation shows that the level of mRNA FCGR3A and FCGR3B in patients with medium differentiation was higher and statistically significant than in patient with lower differentiation. Conclusion. The Changes in the mRNA level of genes encoding CD16A (FCGR3A) and CD16B (FCGR3A) was detected in blood and tumor samples. The results indicate the potential use of these indicators as monitoring immunological markers in hyperplasia and prostate cancer.
Разработка проекта системы информационной поддержки процесса учёта средств индивидуальной защиты сотрудников предприятия
Authors: Тимофеева Н.В. , Красильникова А.М.
Published: December 2021

Статья посвящена вопросу оптимизации процесса оформления и выдачи средств индивидуальной защиты. В данной работе приведен вариант разработки техно-рабочего проекта решения проблем, возникающих в ходе заказа, получения, выдачи и возврата средств индивидуальной защиты.
Единая технология борьбы с контрафактной продукцией
Authors: Шуменко В.Н.
Published: December 2021

В 2005 году был разработан способ борьбы с контрафактной продукцией. Он основан на том, что производитель самостоятельно, без участия третьих лиц, наносит защитную маркировку. Маркировка выполнена таким образом, что предоставляет возможность покупателю проверить подлинность товара до его покупки, после чего покупатель принимает решение купить товар тли нет. Товары длительного пользования покупатель проверяет дважды: до покупки и после покупки. Если, после покупки и проверки у производителя, товар оказался контрафактным, то покупатель может вернуть его продавцу. Перевозчик, получив товар у производителя, ставит дополнительно свою защитную маркировке, подтверждаю продавцу происхождение товара
Правовой статус патентного поверенного
Authors: Горбунова М.В.
Published: December 2021

Патентный поверенный - это, прежде всего, профессиональный представитель интересов определённой категории лиц - заявителей, правообладателей, а также иных заинтересованных лиц в области охраны прав интеллектуальной собственности, наделённый соответствующим правовым статусом. Патентные поверенные - это посредники. Они представляют и защищают права и законные интересы изобретателей, хозяйствующих субъектов разработчиков новой техники, товаропроизводителей, т.е. рынок и свободную конкуренцию. В настоящей статье автором предпринята попытка научного анализа и критического осмысления правового статуса патентного поверенного.
Феномен готовности к деятельности в профессиональной подготовке военных авиационных специалистов
Authors: Карабанова О.Р.
Published: December 2021

В статье рассматривается феномен готовности к деятельности в профессиональной подготовке авиационных специалистов. Актуальность темы обуславливается тем, что в современных исследованиях установлена тесная взаимосвязь между готовностью к деятельности и результатом профессиональной деятельности на практике. Автор раскрывает определения «готовности к деятельности», объясняет отличие данного феномена от способности к деятельности. Главное внимание обращается на содержание структуры готовности к летной деятельности, в которой выделяется мотивационный, когнитивный, профессиональный и рефлексивный компоненты, дается их краткое описание.
Профессор Д. П. Бровкин и его способ патогенетического лечения преэклампсии сульфатом магния
Authors: Голда Т.Е. , Богданов Ю.А. , Долгов Г.В.
Published: December 2021

В статье излагаются биографические данные отечественного акушерагинеколога, профессора Центрального НИИ акушерства и гинекологии - Дмитрия Павловича Бровкина и его способ лечения эклампсии сульфатом магния.
Советское государство в критические периоды своей истории: некоторые дискуссионные и спорные вопросы
Authors: Худобородов А.Л. , Самохина А.В.
Published: December 2021

В данной статье дан анализ развития СССР в очень сложные, критические периоды – Великая Отечественная война и распад СССР. Несмотря на наличие разных точек зрения на происходящие события, в частности сотрудничество с фашистами против советского политического режима, причины разрушения СССР есть то, что их объединяет – не безразличное отношение к Советскому союзу.
Вклад славянофильства в развитие европейской религиозно-философской мысли ХХ в.
Authors: Энеева Н.Т.
Published: December 2021

Статья посвящена вкладу славянофильского направления в развитие христианской религиозно-философской мысли ХХ-ого века. Апробированная почти двумя столетиями историко-богословской дискуссии, поднятая славянофилами проблематика явила себя в конечном итоге как преимущественно экклезиологическая. Подчеркивается, что в данной концепции история Церкви и народа как ее носителя – «народа-богоносца» - предстает не в качестве локальной темы, но как основной сюжет и сущностный смысл мирового исторического процесса.
Проблемы России: кто виноват, и что делать
Authors: Парчевский В.М.
Published: December 2021

На основе 40-летнего опыта работы в техническом вузе автор дает ответы на самые важные для россиянина вопросы: кто виноват и что делать в сфере образования. Ответ на первый вопрос: нужно подойти к зеркалу и посмотреть в него. Ответ на второй вопрос: необходимо повышать моральный уровень населения страны, качество человеческого капитала. Это должно стать национальной идеей, здесь ключ к решению наших проблем.
Анализ мотивации учащихся при поступлении в ВУЗ на примере инженернотехнического института СВФУ
Authors: Цой Т.В.
Published: December 2021

Выбор профессии – довольно сложный и порой долгий мотивационный процесс, так как профессиональная деятельность в жизни человека является основной в обеспечении его социальных притязаний, самоутверждения и самореализации, и к ее выбору нужно отнестись очень серьезно. В данной статье рассматриваются мотивации поступления в инженерно-технический институт Северо-Восточного федерального университета им. М.К. Аммосова (СВФУ). Анализируются факторы, мешающие им успешно учиться, а в дальнейшем получить профессию. Даны рекомендации по улучшению набора будущих студентов.
Дистанционное обучение: сильные и слабые стороны
Authors: Чотчаева М.К.
Published: December 2021

Внезапная вспышка смертельной болезни под названием Covid-19, вызванной вирусом короны (SARS-CoV-2), потрясла весь мир. Всемирная организация здравоохранения объявила это пандемией. Эта ситуация бросила вызов системе образования во всем мире и вынудила преподавателей мгновенно перейти на онлайн-режим обучения. Многие академические учреждения, которые ранее не хотели менять свой традиционный педагогический подход, не имели другого выбора, кроме как полностью перейти на онлайнобучение. Статья включает в себя важность онлайн-обучения и анализ сильных и слабых сторон, возможностей и проблем режимов электронного обучения во время кризиса.
The main directions of the theoretical analysis the problem of forming university students’ communicative self-efficiency
Authors: Pasechkina T.N.
Published: December 2021

The theoretical prerequisites for the formation of university students‘ communicative selfefficacy are considered: the conceptual apparatus, assessment and diagnostic tools, organizational and pedagogical conditions. In general, the position of the author on the subject of solving the problem of future specialists‘ communicative education is presented.