bluuebunny/crossref_metadata_2025 huggingface dataset:
Thermoelastic Response Induced by Volumetric Absorption of Uniform Laser Radiation in a Half-Space
Authors: Tayel Ismail M.
Published: March 2020

In this paper, the thermoelastic response in a generalized thermoelastic half-space induced by absorption of a penetrating pulsed laser radiation inside the medium is studied using the generalized theory with Dual-Phase-Lag (DPL). The surface of the target is considered stresses free and exposed to temperature-dependent heat losses. Laplace integral transform is used analytically for obtaining the general solution, while its inverse is carried out numerically. The copper element is used as an application to compare the predictions induced by volumetric absorption of the Dual-Phase-lag theory with those for Lord–Shulman (LS) and classical coupled (CTE) theories, moreover the response induced by volumetric absorption for (LS) and (CTE) models in this work were compared with those induced by surface absorption in a previous work.
Study of the Durability and Aesthetical Properties of Powder Coatings Admixed with Pearlescent Pigments
Authors: Rossi Stefano , Russo Francesca , Bouchakour Rahmani Lotfi
Published: March 2020

Powder coatings are commonly used to protect metallic substrates because of their good protection properties together with their aesthetical ones. In this work, the aesthetic and functional properties of powder coatings admixed with pearlescent pigments were investigated. The main aim of this work is represented by the evaluation of the coating properties and their change assessment after accelerated ageing treatments, such as UV and salt spray exposure. Changes in gloss, color and roughness were recorded before, during, and after UVA and UVB exposure. All the samples showed good resistance to UVA irradiation, whereas UVB light caused a huge variation in surface properties. Further insights on the degradation of the polymeric matrix were gained by exploiting FT-IR analyses, which could be correlated to the change of color. The protection properties of the coating were assessed by exploiting an acetic salt spray test. All the samples showed good resistance to aggressive environments, and no pigment effect on the degradation of the coatings could be detected.
Tribocorrosive Study of New and In Vivo Exposed Nickel Titanium and Stainless Steel Orthodontic Archwires
Authors: Kosec Tadeja , Močnik Petra , Mezeg Uroš , Legat Andraž , Ovsenik Maja , Jenko Monika , Grant John T. , Primožič Jasmina
Published: March 2020

The surface, corrosion and wear properties of new and in vivo exposed nickel titanium (NiTi) and stainless steel (SS) archwires used in orthodontic treatment were investigated. Electrochemical and tribo-electrochemical tests in artificial saliva were performed in order to define corrosion properties and to estimate wear rate of new and in vivo exposed NiTi and SS archwires. The surface chemical analysis of the passive film on the NiTi and SS archwires before and after tribocorrosion tests was performed by Auger Electron Spectroscopy (AES). In vivo exposed NiTi and SS archwires had better electrochemical properties than new archwires due to the protective nature of oral deposits. Total wear and coefficients of friction were higher among in vivo exposed archwires and higher in NiTi archwires in comparison to SS archwires. The estimated thickness of the TiO2 passive film on as-received NiTi is 8 nm, while the passive Cr2O3 film on as-received SS is just 1–2 nm. On in vivo exposed NiTi archwire, a 60–80 nm thick organic film/dental plaque was observed, and on SS, it was thinner, at about 60 nm. This research shows the importance of combining AES with electrochemical testing, to characterize tribocorrosive properties of NiTi and SS orthodontic archwires.
A Novel Halogen Bond Acceptor: 1-(4-Pyridyl)-4-Thiopyridine (PTP) Zwitterion
Authors: Ding Xin , Tuikka Matti , Haukka Matti
Published: March 2020

Sulfur is a widely used halogen bond (XB) acceptor, but only a limited number of neutral XB acceptors with bifurcated sp3-S sites have been reported. In this work a new bidentate XB acceptor, 1-(4-pyridyl)-4-thiopyridine (PTP), which combines sp3-S and sp2-N acceptor sites, is introduced. Three halogen bonded cocrystals were obtained by using 1,4-diiodobenzene (DIB), 1,4-diiodotetrafluorobenzene (DIFB), and iodopentafluorobenzene (IPFB) as XB donors and PTP as acceptor. The structures of the cocrystals showed some XB selectivity between the S and N donors in PTP. However, the limited contribution of XB to the overall molecular packing in these three cocrystals and the results from DSC measurements clearly point out the synergetic influence and interplay of all noncovalent interactions in crystal packing of these compounds.
Experimental Study on Zn-Doped Al-Rich Alloys for Fast on-Board Hydrogen Production
Authors: Liu Dan , Gao Qian , An Qi , Wang Hongchao , Wei Jilun , Wei Cundi
Published: March 2020

For the purpose of investigating the effect of Zn replacement of In3Sn on the hydrogen production performance of Al-rich alloy ingots, Al-Ga-In3Sn alloys with various Zn dosages (0–5 wt.%) were prepared by a traditional melting and casting technique. The phase compositions and microstructures were characterized using X-ray diffractometer (XRD) and scanning electron microscope (SEM) with an Energy Dispersed X-ray system (EDS). The SEM results indicate that, with a small amount of Zn instead of In3Sn, the number and total area of grain boundary (GB) phases will decrease gradually, and the average single GB area will eventually stabilize. The distribution of Zn in the alloy is similar to that of Ga, and an area with high Zn content appeared in the high-Zn-doped sample. The melting behaviors of Al with other metals were measured by DSC. The reaction of these alloys and water were investigated at different temperatures. Compared with Al-Ga-In3Sn alloy, low addition of Zn changed the composition of GB phase and increased the maximum hydrogen production rate. The reason for the changes in the hydrolysis reaction of Al with the addition of Zn was discussed.
Video Laryngoscopic Intubation Using the King VisionTM Laryngoscope in a Simulated Cervical Spine Trauma: A Comparison Between Non-Channeled and Channeled Disposable Blades
Authors: Votruba Jiri , Brozek Tomas , Blaha Jan , Henlin Tomas , Vymazal Tomas , Donaldson Will , Michalek Pavel
Published: March 2020

Videolaryngoscopes may reduce cervical spine movement during tracheal intubation in patients with neck trauma. This manikin study aimed to compare the performance of disposable non-channeled and channeled blades of the King Vision™ videolaryngoscope in simulated cervical spine injury. Fifty-eight anesthesiologists in training intubated the TruMan manikin with the neck immobilized using each blade in a randomized order. The primary outcome was the time needed for tracheal intubation, secondary aims included total success rate, the time required for visualization of the larynx, number of attempts, view of the vocal cords, and subjective assessment of both methods. Intubation time with the channeled blade was shorter, with a median time of 13 s (IQR 9–19) vs. 23 s (14.5–37.5), p < 0.001, while times to visualization of the larynx were similar in both groups (p = 0.54). Success rates were similar in both groups, but intubation with the non-channeled blade required more attempts (1.52 vs. 1.05; p < 0.001). The participants scored the intubation features of the channeled blade significantly higher, while visualization features were scored similarly in both groups. Both blades of the King Vision™ videolaryngoscope are reliable intubation devices in a simulated cervical spine injury in a manikin model when inserted by non-experienced operators. The channeled blade allowed faster intubation of the trachea.
Generative Adversarial Network-Based Neural Audio Caption Model for Oral Evaluation
Authors: Zhang Liu , Shu Chao , Guo Jin , Zhang Hanyi , Xie Cheng , Liu Qing
Published: March 2020

Oral evaluation is one of the most critical processes in children’s language learning. Traditionally, the Scoring Rubric is widely used in oral evaluation for providing a ranking score by assessing word accuracy, phoneme accuracy, fluency, and accent position of a tester. In recent years, by the emerging demands of the market, oral evaluation requires not only providing a single score from pronunciation but also in-depth, meaning comments based on content, context, logic, and understanding. However, the Scoring Rubric requires massive human work (oral evaluation experts) to provide such deep meaning comments. It is considered uneconomical and inefficient in the current market. Therefore, this paper proposes an automated expert comment generation approach for oral evaluation. The approach first extracts the oral features from the children’s audio as well as the text features from the corresponding expert comments. Then, a Gated Recurrent Unit (GRU) is applied to encode the oral features into the model. Afterwards, a Long Short-Term Memory (LSTM) model is applied to train the mappings between oral features and text features and generate expert comments for the new coming oral audio. Finally, a Generative Adversarial Network (GAN) is combined to improve the quality of the generated comments. It generates pseudo-comments to train the discriminator to recognize the human-like comments. The proposed approach is evaluated in a real-world audio dataset (children oral audio) collected by our collaborative company. The proposed approach is also integrated into a commercial application to generate expert comments for children’s oral evaluation. The experimental results and the lessons learned from real-world applications show that the proposed approach is effective for providing meaningful comments for oral evaluation.
Development of an Efficient Cooling Strategy in the Heading Face of Underground Mines
Authors: Li Xian , Fu Houli
Published: March 2020

Heat damage in deep mines is severe and can lead to adverse health effects. The existing refrigeration schemes for the heading face in excavation roadways aim to cool the whole cooling region. However, the ratio of the area occupied by workers to that of the cooling region is quite small. A great quantity of energy for refrigeration is doomed to waste. In this study, a new cooling strategy for building a non-uniform environment in the heading face was developed. A certain quantity of well-designed tracking air coolers were distributed in the excavation roadway near the heading face. The air cooler tracked the constantly moving workers and blew cold air to them. Economic analysis based on estimation of the cooling load for this cooling strategy was conducted. The airflow in the excavation roadway was numerically simulated to estimate the cooling effect. An average energy saving of approximately 30% could be realized. The thermal environment for the workers whether near the heading face or in the roadway improved. This cooling strategy should be considered in all of mine cooling.
The Rule of Carrying Cuttings in Horizontal Well Drilling of Marine Natural Gas Hydrate
Authors: Wei Na , Liu Yang , Cui Zhenjun , Jiang Lin , Sun Wantong , Xu Hanming , Wang Xiaoran , Qiu Tong
Published: March 2020

Horizontal well drilling is a highly effective way to develop marine gas hydrate. During the drilling of horizontal wells in the marine gas hydrate layer, hydrate particles and cutting particles will migrate with the drilling fluid in the horizontal annulus. The gravity of cuttings is easy to deposit in the horizontal section, leading to the accumulation of cuttings. Then, a cuttings bed will be formed, which is not beneficial to bring up cuttings and results in the decrease of wellbore purification ability. Then the extended capability of the horizontal well will be restricted and the friction torque of the drilling tool will increase, which may cause blockage of the wellbore in severe cases. Therefore, this paper establishes geometric models of different hole enlargement ways: right-angle expansion, 45-degree angle expansion, and arc expanding. The critical velocity of carrying rock plates are obtained by EDEM and FLUENT coupling simulation in different hydrate abundance, different hydrate-cuttings particle sizes and different drilling fluid density. Then, the effects of hole enlargement way, particle size, hydrate abundance and drilling fluid density on rock carrying capacity are analyzed by utilizing an orthogonal test method. Simulation results show that: the critical flow velocity required for carrying cuttings increases with the increase of the particle size of the hydrate-cuttings particle when the hydrate abundance is constant. The critical flow velocity decreases with the increase of drilling fluid density, the critical flow velocity carrying cuttings decreases with the increase of hydrate abundance when the density of the drilling fluid is constant. Orthogonal test method was used to evaluate the influence of various factors on rock carrying capacity: hydrate-cuttings particle size > hole enlargement way > hydrate abundance > drilling fluid density. This study provides an early technical support for the construction parameter optimization and well safety control of horizontal well exploitation models in a marine natural gas hydrate reservoir.
Processing and Technology of Dairy Products: A Special Issue
Authors: Deeth Hilton , Kelly Phil
Published: March 2020

When this Special Issue was launched, we cast the net widely in terms of the subject matter we considered suitable for the papers [...]
Down Regulation and Loss of Auxin Response Factor 4 Function Using CRISPR/Cas9 Alters Plant Growth, Stomatal Function and Improves Tomato Tolerance to Salinity and Osmotic Stress
Authors: Bouzroud Sarah , Gasparini Karla , Hu Guojian , Barbosa Maria Antonia Machado , Rosa Bruno Luan , Fahr Mouna , Bendaou Najib , Bouzayen Mondher , Zsögön Agustin , Smouni Abdelaziz , Zouine Mohamed
Published: March 2020

Auxin controls multiple aspects of plant growth and development. However, its role in stress responses remains poorly understood. Auxin acts on the transcriptional regulation of target genes, mainly through Auxin Response Factors (ARF). This study focuses on the involvement of SlARF4 in tomato tolerance to salinity and osmotic stress. Using a reverse genetic approach, we found that the antisense down-regulation of SlARF4 promotes root development and density, increases soluble sugars content and maintains chlorophyll content at high levels under stress conditions. Furthermore, ARF4-as displayed higher tolerance to salt and osmotic stress through reduced stomatal conductance coupled with increased leaf relative water content and Abscisic acid (ABA) content under normal and stressful conditions. This increase in ABA content was correlated with the activation of ABA biosynthesis genes and the repression of ABA catabolism genes. Cu/ZnSOD and mdhar genes were up-regulated in ARF4-as plants which can result in a better tolerance to salt and osmotic stress. A CRISPR/Cas9 induced SlARF4 mutant showed similar growth and stomatal responses as ARF4-as plants, which suggest that arf4-cr can tolerate salt and osmotic stresses. Our data support the involvement of ARF4 as a key factor in tomato tolerance to salt and osmotic stresses and confirm the use of CRISPR technology as an efficient tool for functional reverse genetics studies.
Comments on “On a Continuum Model for Avalanche Flow and Its Simplified Variants” by S. S. Grigorian and A. V. Ostroumov
Authors: Issler Dieter
Published: March 2020

This note first summarizes the history of the manuscript “On a Continuum Model for Avalanche Flow and Its Simplified Variants” by Grigorian and Ostroumov—published in this Special Issue—since the early 1990s and explains the guiding principles in editing it for publication. The changes are then detailed and some explanatory notes given for the benefit of readers who are not familiar with the early Russian work on snow avalanche dynamics. Finally, the editor’s personal views as to why he still considers this paper of relevance for avalanche dynamics research today are presented in brief essays on key aspects of the paper, namely the role of simple and complex models in avalanche research and mitigation work, the status and possible applications of Grigorian’s stress-limited friction law, and non-monotonicity of the dynamics of the Grigorian–Ostroumov model in the friction coefficient. A comparison of the erosion model proposed by those authors with two other models suggests to enhance it with an additional equation for the balance of tangential momentum across the shock front. A preliminary analysis indicates that continuous scouring entrainment is possible only in a restricted parameter range and that there is a second erosion regime with delayed entrainment.
The Potential Use of Ground Conductivity Meters to Identify the Location of Seepages—Case Study of the Maniów Levee near Krakow, Poland
Authors: Klityński Wojciech , Oryński Szymon , Chau Nguyen Dinh
Published: March 2020

This paper presents an assessment of the potential usefulness of the Ground Conductivity Meter (GCM) method to locate seepage pathways in the Maniow levee zone near Kraków, Poland. We have realized this aim through geological recognition of the study area, which requires the implementation of GCM data inversion measured in the sounding version. The GCM measurements were performed along with the net of profiles using combined data from CMD Mini Explorer and CMD Explorer equipment. The methodology of the one-dimensional (1D) inversion of the GCM soundings located along profiles is presented in the article. The legitimacy of the inversion and the relationship of the results obtained in the form of conductivity sections along profiles with geology have been verified in detail. The inversion procedures were tested on the synthetic GCM soundings obtained from modeling processes, by using the electrical conductivity and thicknesses, known from the drilled formations and additionally based on DC-R sounding data. These soundings were performed at some selected reference points in the levee zone. We have used our software and IX1D Interpex software to calculate the forward modeling. Quantitative interpretation processed along the profiles has been proceeded by 1D inversion of GCM data at several referential points located close to boreholes and DC soundings. It was done to verify the correctness of the quantitative interpretation. The geoelectrical models, obtained in a section form, were correlated with the borehole lithology data, providing a reference geological structure in some places. As a result of the work mentioned above, the potential seepage zones were located on the conductivity sections. The thickness of the cohesive silty clay layer, lying near to the surface, in the seepage zones, was thin enough and less than a meter. When the water level in the Vistula river was high enough, water can flow in the noncohesive gravel layer occurring directly below the silty clays and lead to flooding on the landward side of the dams in the Maniow region.
Evaluating Rockfall Risk: Some Critical Aspects
Authors: Scavia Claudio , Barbero Monica , Castelli Marta , Marchelli Maddalena , Peila Daniele , Torsello Giulia , Vallero Gianmarco
Published: March 2020

Rockfalls evolve rapidly and unpredictably in mountain environments and can cause considerable losses to human societies, structures, economical activities, and also natural and historical heritage. Rockfall risk analyses are complex and multi-scale processes involving several disciplines and techniques. This complexity is due to the main features of rockfall phenomena, which are extremely variable over space and time. Today, a considerable number of methods exists for protecting land, as well as assessing and managing the risk level. These methodologies are often very different from each other, depending on the data required, the purposes of the analysis, and the reference scale adopted, i.e., the analysis level of detail. Nevertheless, several questions still remain open with reference to each phase of the hazard and risk process. This paper is devoted to a general overview of existing risk estimation methodologies and a critical analysis of some open questions with the aim of highlighting possible further research topics. A typical risk assessment framework is exemplified by analyzing a real case study. Each step of the process is treated at both the detailed and the large scale in order to highlight the main characteristics of each level of detail.
Cognitive Status and Outcomes of Older People in Orthopedic Rehabilitation? A Retrospective-Cohort Study
Authors: Bernal Carrillo Carissa , Barr Christopher , George Stacey
Published: March 2020

Background: Cognitive function of older people is not routinely assessed in orthopedic rehabilitation, after elective and non-elective surgery. The aim of this study was to assess cognitive impairment and its impact on both length of stay and functional outcomes, of older people admitted to orthopedic rehabilitation. Methods: Retrospective audit, inclusion criteria: aged >65 years, orthopedic diagnosis, discharged from hospital. Results: 116 files were audited, mean age of 82.3 (SD = 7.5) years. Diagnostic groups: fractured neck of femur, (n = 44, 37.98%); elective surgery (n = 42, 36.21%); and other orthopedic conditions (n = 30, 25.86%). Overall 71.55% (n = 83) had cognitive impairment, with a median of mild cognitive impairment across all diagnoses. Both measures of cognition (MoCA/FIM Cognitive) were significantly associated with length of stay (p < 0.01), function (p < 0.05), and discharge destination (p = 0.01). Conclusions: A high percentage of older orthopedic patients in rehabilitation with both elective and non-elective diagnoses have cognitive impairment. Cognitive screening is recommended for all older orthopedic patients in rehabilitation, to inform an individualized rehabilitation plan to improve outcomes and length of stay. Further research is required to explore cognitive strategies to maximize rehabilitation outcomes in the geriatric orthopedic population.
Dividend Policy and Institutional Holdings: Evidence from Australia
Authors: Nguyen Thao , Li Hui
Published: March 2020

This paper investigates the relationship between dividend payout and institutional ownership for all Australian listed firms in the period between 2001 and 2015. In our univariate tests, we find that institutional investors, in general, prefer dividend-paying firms more than non-paying firms, and for the dividend-paying firms in our sample, institutional investors hold more shares in the firms who pay higher dividends. We further explore the causality between dividend payout and institutional ownership in our multivariate tests with our panel data. The results show an insignificant effect of institutional ownership (dividend payout) on the future dividend payout (institutional ownership) while controlling for firms’ fundamentals, that a higher dividend yield does not attract more institutional investors and that there is no catering to Australian institutional investors.
GIScience Theory Based Assessment of Spatial Disparity of Geodetic Control Points Location
Authors: Bielecka Elzbieta , Pokonieczny Krzysztof , Borkowska Sylwia
Published: March 2020

Geodetic networks provide a spatial reference framework for the positioning of any geographical feature in a common and consistent way. An even spatial distribution of geodetic control points assures good quality for subordinate surveys in mapping, cadaster, engineering activities, and many other land administration-oriented applications. We investigate the spatial pattern of geodetic control points based on GIScience theory, especially Tobler’s Laws in Geography. The study makes contributions in both the research and application fields. By utilizing Average Nearest Neighbor, multi-distance spatial cluster analysis, and cluster and outlier analysis, it introduces the comprehensive methodology for ex post analysis of geodetic control points’ spatial patterns as well as the quantification of geodetic networks’ uniformity to regularly dense and regularly thinned. Moreover, it serves as a methodological resource and reference for the Head Office of Geodesy and Cartography, not only the maintenance, but also the further densification or modernization the geodetic network in Poland. Furthermore, the results give surveyors the ability to quickly assess the availability of geodetic points, as well as identify environmental obstacles that may hamper measurements. The results show that the base geodetic control points are evenly dispersed (one point over 50 sq. km), however they tend to cluster slightly in urbanized areas and forests (1.3 and 1.4 points per sq. km, respectively).
Regulatory Mechanism of MicroRNA Expression in Cancer
Authors: Ali Syeda Zainab , Langden Siu Semar Saratu’ , Munkhzul Choijamts , Lee Mihye , Song Su Jung
Published: March 2020

Altered gene expression is the primary molecular mechanism responsible for the pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are virtually involved at the post-transcriptional level and bind to 3′ UTR of their target messenger RNA (mRNA) to suppress expression. Dysfunction of miRNAs disturbs expression of oncogenic or tumor-suppressive target genes, which is implicated in cancer pathogenesis. As such, a large number of miRNAs have been found to be downregulated or upregulated in human cancers and to function as oncomiRs or oncosuppressor miRs. Notably, the molecular mechanism underlying the dysregulation of miRNA expression in cancer has been recently uncovered. The genetic deletion or amplification and epigenetic methylation of miRNA genomic loci and the transcription factor-mediated regulation of primary miRNA often alter the landscape of miRNA expression in cancer. Dysregulation of the multiple processing steps in mature miRNA biogenesis can also cause alterations in miRNA expression in cancer. Detailed knowledge of the regulatory mechanism of miRNAs in cancer is essential for understanding its physiological role and the implications of cancer-associated dysfunction and dysregulation. In this review, we elucidate how miRNA expression is deregulated in cancer, paying particular attention to the cancer-associated transcriptional and post-transcriptional factors that execute miRNA programs.
Nature of Attractive Multiplayer Games: Case Study on China’s Most Popular Card Game—DouDiZhu
Authors: Gao Yuexian , Li Wanxiang , Xiao Yuhao , Khalid Mohd Nor Akmal , Iida Hiroyuki
Published: March 2020

DouDiZhu, a multiplayer game with incomplete information, is the most popular card game in China. Although there are many DouDiZhu card games in the world, the specific characteristics of classical DouDiZhu card games are a harmonious combination of player numbers, player characters (landlords and peasants), deck numbers, and scoring systems. However, research on the complexity and attractiveness of DouDiZhu has not established. Therefore, in this paper, artificial intelligence (AI) players of different levels of DouDiZhu game were constructed for research, self-game simulation was conducted for DouDiZhu AI players, and game refinement measures were used to evaluate and identify the best Settings of the game. The results show that classical DouDiZhu provides the most complex game setup for all types of DouDiZhu AI players, while also clarifying its popularity.
First Report of Aleurocanthus spiniferus on Ailanthus altissima: Profiling of the Insect Microbiome and MicroRNAs
Authors: Bubici Giovanni , Prigigallo Maria Isabella , Garganese Francesca , Nugnes Francesco , Jansen Maurice , Porcelli Francesco
Published: March 2020

We report the first occurrence of the orange spiny whitefly (Aleurocanthus spiniferus; OSW) on the tree of heaven (Ailanthus altissima) in Bari, Apulia region, Italy. After our first observation in 2016, the infestation recurred regularly during the following years and expanded to the neighboring trees. Since then, we have also found the insect on numerous patches of the tree of heaven and other plant species in the Bari province. Nevertheless, the tree of heaven was not particularly threatened by the insect, so that a possible contribution by OSW for the control of such an invasive plant cannot be hypothesized hitherto. This work was also aimed at profiling the microbiome of OSW feeding on A. altissima. For this purpose, we used the denaturing gradient gel electrophoresis (DGGE) and the deep sequencing of small RNAs (sRNAs). Both techniques unveiled the presence of “Candidatus Portiera” (primary endosymbiont), Wolbachia sp. and Rickettsia sp., endosymbionts already reported for other Aleyrodidae. Deep sequencing data were analyzed by four computational pipelines in order to understand the reliability of the detection of fungi, bacteria, and viruses: Kraken, Kaiju, Velvet, and VelvetOptimiser. Some contigs assembled by Velvet or VelvetOptimiser were associated with insects, but not necessarily in the Aleurocanthus genus or Aleyrodidae family, suggesting the non-specificity of sRNAs or possible traces of parasitoids in the sample (e.g., Eretmocerus sp.). Finally, deep sequencing data were used to describe the microtranscriptome of OSW: 56 canonical and at least four high-confidence novel microRNAs (miRNAs) were identified. The overall miRNA abundance in OSW was in agreement with previous works on Bemisia tabaci, and bantam-3p, miR-276a-3p, miR-317-3p, miR-750-3p, and mir-8-3p were the most represented miRNAs.
Lymphadenectomy is Unnecessary for Pure Ground-Glass Opacity Pulmonary Nodules
Authors: Lin Yi-Han , Chen Chun-Ku , Hsieh Chih-Cheng , Hsu Wen-Hu , Wu Yu-Chung , Hung Jung-Jyh , Hsu Po-Kuei , Hsu Han-Shui
Published: March 2020

Background: Lobectomy plus lymph node dissection is the standard treatment of early-stage lung cancer, but the low lymph node metastasis rate with ground-glass opacity (GGO) makes surgeons not perform lymphadenectomy. This study aimed to re-evaluate the lymph node metastasis rate of GGO to help make a clinical judgment. Methods: We performed this retrospective study to enroll patients who received lung cancer surgery from 2011 to 2016. Patient characteristics collected included tumor size, solid part size and lymph node metastasis rate. These patients were categorized into pure GGO and part solid GGO groups to undergo analysis. Results: Lymph node metastasis rates were 0%, 3.8% and 6.9% in order of the pure GGO group, the GGO predominant group and the solid predominant group. In the lobectomy patients, the solid predominant group still showed to have the highest lymph node metastasis rate and recurrence rate (8.3% and 10.1%). Conclusion: It is unnecessary to perform lymphadenectomy for patients with pure GGO in view of the 0% lymph node metastasis rate. The higher lymph node metastasis rate in the patients with the solid predominant group, 6.9%, suggested that surgeons should choose a rational lymphadenectomy method according to their GGO property and clinical judgment.
Additional Value of Machine-Learning Computed Tomographic Angiography-Based Fractional Flow Reserve Compared to Standard Computed Tomographic Angiography
Authors: Lossnitzer Dirk , Chandra Leonard , Rutsch Marlon , Becher Tobias , Overhoff Daniel , Janssen Sonja , Weiss Christel , Borggrefe Martin , Akin Ibrahim , Pfleger Stefan , Baumann Stefan
Published: March 2020

Background: Machine-learning-based computed-tomography-derived fractional flow reserve (CT-FFRML) obtains a hemodynamic index in coronary arteries. We examined whether it could reduce the number of invasive coronary angiographies (ICA) showing no obstructive lesions. We further compared CT-FFRML-derived measurements to clinical and CT-derived scores. Methods: We retrospectively selected 88 patients (63 ± 11years, 74% male) with chronic coronary syndrome (CCS) who underwent clinically indicated coronary computed tomography angiography (cCTA) and ICA. cCTA image data were processed with an on-site prototype CT-FFRML software. Results: CT-FFRML revealed an index of >0.80 in coronary vessels of 48 (55%) patients. This finding was corroborated in 45 (94%) patients by ICA, yet three (6%) received revascularization. In patients with an index ≤ 0.80, three (8%) of 40 were identified as false positive. A total of 48 (55%) patients could have been retained from ICA. CT-FFRML (AUC = 0.96, p ≤ 0.0001) demonstrated a higher diagnostic accuracy compared to the pretest probability or CT-derived scores and showed an excellent sensitivity (93%), specificity (94%), positive predictive value (PPV; 93%) and negative predictive value (NPV; 94%). Conclusion: CT-FFRML could be beneficial for clinical practice, as it may identify patients with CAD without hemodynamical significant stenosis, and may thus reduce the rate of ICA without necessity for coronary intervention.
The Effects of Geometry and Chemical Composition of Nanoparticles on The Fracture Toughness of iPP Nanocomposites
Authors: Stern Nadya , Hu Xiao , Marom Gad
Published: March 2020

This research deals with possible hybrid effects in the fracture energy of hybrid nanocomposites while taking a critical approach toward the currently-prevailing engineering practice of applying classical composite micromechanics to nanocomposites. For this purpose, different nanoparticles were embedded in an isotactic polypropylene matrix. The particles had different geometries (fibrous and platelets) and different chemical structures (organic vapor grown carbon nanofibers (VGCF); graphene nanoplatelets (GNP); and inorganic nanoclays, SiO2 nanofibers, and ZrO2 nanofibers). Almost all the composite systems presented improvements in the fracture energy, whereas the iPP/VGCF/GNP presented a positive hybrid effect. The main conclusion was that each nanocomposite system should be analyzed individually according to the constituent properties; the quality of the dispersion; and, primarily, by the type of interaction between the particles and the matrix.
Performance Comparison of Subtractive and Additive Machine Tools for Meso-Micro Machining
Authors: Liu (Peter) , Gershenfeld Neil
Published: March 2020

Several series of experiments were conducted to compare the performance of selected sets of subtractive and additive machine tools for meso-micro machining. Under the MicroCutting Project, meso-micro machining of a reference part was conducted to compare the performance of several machine tools. A prototype flexure of the microspline of an asteroid gripper under development at NASA/JPL was selected as the reference part for the project. Several academic, research institutes, and industrial firms were among the collaborators participating in the project. Both subtractive and additive machine tools were used, including abrasive waterjets, CNC milling, lasers, 3D printing, and laser powder bed fusion. Materials included aluminum, stainless steel, and nonmetal resins. Each collaborator produced the reference part in its facility using materials most suitable for their tools. The finished parts were inspected qualitatively and quantitatively at OMAX Corporation. The performance of the participating machine tools was then compared based on the results of the inspection. Test results show that the two top performers for this test part are the CNC precision milling and micro abrasive waterjet. For machining a single flexure, the CNC precision milling had a slight edge over the micro abrasive waterjet machining in terms of part accuracy and edge quality. The advantages disappear or the trend even reverses when stack machining with taper compensation is adopted for the micro abrasive waterjet.
Evolution of Life on Earth: tRNA, Aminoacyl-tRNA Synthetases and the Genetic Code
Authors: Lei Lei , Burton Zachary F
Published: March 2020

Life on Earth and the genetic code evolved around tRNA and the tRNA anticodon. We posit that the genetic code initially evolved to synthesize polyglycine as a cross-linking agent to stabilize protocells. We posit that the initial amino acids to enter the code occupied larger sectors of the code that were then invaded by incoming amino acids. Displacements of amino acids follow selection rules. The code sectored from a glycine code to a four amino acid code to an eight amino acid code to an ~16 amino acid code to the standard 20 amino acid code with stops. The proposed patterns of code sectoring are now most apparent from patterns of aminoacyl-tRNA synthetase evolution. The Elongation Factor-Tu GTPase anticodon-codon latch that checks the accuracy of translation appears to have evolved at about the eight amino acid to ~16 amino acid stage. Before evolution of the EF-Tu latch, we posit that both the 1st and 3rd anticodon positions were wobble positions. The genetic code evolved via tRNA charging errors and via enzymatic modifications of amino acids joined to tRNAs, followed by tRNA and aminoacyl-tRNA synthetase differentiation. Fidelity mechanisms froze the code by inhibiting further innovation.
Injection 3D Concrete Printing (I3DCP): Basic Principles and Case Studies
Authors: Hack Norman , Dressler Inka , Brohmann Leon , Gantner Stefan , Lowke Dirk , Kloft Harald
Published: March 2020

Today, the majority of research in 3D concrete printing focuses on one of the three methods: firstly, material extrusion; secondly, particle-bed binding; and thirdly, material jetting. Common to all these technologies is that the material is applied in horizontal layers. In this paper, a novel 3D concrete printing technology is presented which challenges this principle: the so-called Injection 3D Concrete Printing (I3DCP) technology is based on the concept that a fluid material (M1) is robotically injected into a material (M2) with specific rheological properties, causing material M1 to maintain a stable position within material M2. Different to the layered deposition of horizontal strands, intricate concrete structures can be created through printing spatially free trajectories, that are unconstrained by gravitational forces during printing. In this paper, three versions of this method were investigated, described, and evaluated for their potential in construction: A) injecting a fine grain concrete into a non-hardening suspension; B) injecting a non-hardening suspension into a fine grain concrete; and C) injecting a fine grain concrete with specific properties into a fine grain concrete with different properties. In an interdisciplinary research approach, various material combinations were developed and validated through physical experiments. For each of the three versions, first architectural applications were developed and functional prototypes were fabricated. These initial results confirmed both the technological and economic feasibility of the I3DCP process, and demonstrate the potential to further expand the scope of this novel technology.
Modal Performance of Two-Fiber Orthogonal Gradient Composite Laminates Embedded with SMA
Authors: Huang Yizhe , Zhang Zhifu , Li Chaopeng , Mao Kuanmin , Huang Qibai
Published: March 2020

A gradient composite laminate that was composed of two-phase fibers, a shape memory alloy (SMA), and graphite was prepared to investigate modal performance and improve vibration behavior. The stress-strain relation of the single-layer composite plates was derived from Kirchhoff thin plate theory and the material constitutive of the SMA. A gradient distribution model and the eigenvalue equations of gradient composite laminates were developed. The influence of the fiber component content gradient distribution, pre-strain, the two-phase fiber volume fraction, and geometric parameters on the modal performance was analyzed. This study provides a method to avoid the structural resonance of composite laminates that are embedded with an SMA through the gradient distribution of two-phase fiber content that leads to the interaction of the material properties.
Multi-Response Optimization in High-Speed Machining of Ti-6Al-4V Using TOPSIS-Fuzzy Integrated Approach
Authors: Abbas Adel T. , Sharma Neeraj , Anwar Saqib , Luqman Monis , Tomaz Italo , Hegab Hussien
Published: March 2020

Titanium alloys are widely used in various applications including biomedicine, aerospace, marine, energy, and chemical industries because of their superior characteristics such as high hot strength and hardness, low density, and superior fracture toughness and corrosion resistance. However, there are different challenges when machining titanium alloys because of the high heat generated during cutting processes which adversely affects the product quality and process performance in general. Thus, optimization of the machining conditions while machining such alloys is necessary. In this work, an experimental investigation into the influence of different cutting parameters (i.e., depth of cut, cutting length, feed rate, and cutting speed) on surface roughness (Rz), flank wear (VB), power consumption as well as the material removal rate (MRR) during high-speed turning of Ti-6Al-4V alloy is presented and discussed. In addition, a backpropagation neural network (BPNN) along with the technique for order of preference by similarity to ideal solution (TOPSIS)-fuzzy integrated approach was employed to model and optimize the overall cutting performance. It should be stated that the predicted values for all machining outputs demonstrated excellent agreement with the experimental values at the selected optimal solution. In addition, the selected optimal solution did not provide the best performance for each measured output, but it achieved a balance among all studied responses.
Study of Partially Transient Organic Epidermal Sensors
Authors: Chen Yuanfen , Jamshidi Reihaneh , Montazami Reza
Published: March 2020

In this study, an all-organic, partially transient epidermal sensor with functional poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) conjugated polymer printed onto a water-soluble polyethylene oxide (PEO) substrate is studied and presented. The sensor’s electronic properties were studied under static stress, dynamic load, and transient status. Electrode resistance remained approximately unchanged for up to 2% strain, and increased gradually within 6.5% strain under static stress. The electronic properties’ dependence on dynamic load showed a fast response time in the range of 0.05–3 Hz, and a reversible stretching threshold of 3% strain. A transiency study showed that the PEO substrate dissolved completely in water, while the PEDOT:PSS conjugated polymer electrode remained intact. The substrate-less, intrinsically soft PEDOT:PSS electrode formed perfect contact on human skin and stayed attached by Van der Waals force, and was demonstrated as a tattoolike epidermal sensor.
High-Power Fiber Laser Cutting for 50-mm-Thick Cement-Based Materials
Authors: Seo Youngjin , Lee Dongkyoung , Pyo Sukhoon
Published: March 2020

This experimental research highlights the applicability of laser cutting to cement-based materials using multimode fiber lasers. A 9 kW multimode fiber laser is used, and the experimental variables are the water-to-cement ratio, laser speed, and material compositions such as cement paste, cement mortar and ultra high performance concrete (UHPC). The laser cutting performance on the cement-based materials is investigated in the downward laser direction. The kerf width and penetration depth of the cement-based materials are quantitatively evaluated with the parameters in the surface and cross section of the specimens after the laser cutting. Moreover, the material removal zone of each specimen is compared in terms of the penetration shapes in the cross-sectional view. Based on experimental observations, the interaction mechanism between the laser and cement-based materials is proposed.
Analysis of the Rolling Process of Alloy 6005 in a Three-High Skew Rolling Mill
Authors: Bajor Teresa , Kulakowska Anna , Dyja Henryk
Published: March 2020

This paper presents the results of numerical modelling of the rolling process of aluminum alloy bars in a three-high skew mill. The purpose of the examination was to determine the optimal rolling temperature for this alloy. The numerical examination for aluminum alloy 6005 (AlZn5.5MgCu) was performed using the Forge3®-2D Plane strain state commercial software. The rheological properties of the examined alloy were determined from uniaxial compression tests done using the metallurgical process simulation system Gleeble 3800. The numerical analysis of the process of rolling 6005 alloy bars in a three-high skew mill was conducted within the temperature range of 150–350 °C and at a deformation of 0.29.
Preparation and Properties of Wood Tar-based Rejuvenated Asphalt
Authors: Zhang Xuefei , Zhu Juncai , Wu Chaofan , Wu Qingding , Liu Kefei , Jiang Kang
Published: March 2020

In order to explore the applicability of the rejuvenated asphalt with wood tar as the main raw material, the orthogonal test was used to determine the optimal ratio of wood tar-based rejuvenator. The physical properties, rheological properties and components of matrix asphalt, aged asphalt, wood tar-based rejuvenated asphalt and commercial RA-102# rejuvenated asphalt were tested and compared. The results show that the optimal ratio of wood tar-based rejuvenator is 15wt% wood tar, 0.3wt% biomass fiber, 5wt% plasticizer, 0.3wt% compatibilizer, and 1wt% stabilizer of the mass of aged asphalt. Wood tar-based rejuvenator can restore the physical properties of the aged asphalt to meet the specification requirements. The synergistic effect of biomass fiber and plasticizer make the wood tar-based rejuvenated asphalt has good resistance to accumulated permanent deformation, but its low-temperature cracking resistance needs to be further improved. During the rejuvenation process of aged asphalt, the colloidal state changes from gel-state to sol-state, characterizing that the viscosity of asphalt decreased and the fluidity increased. Wood tar-based rejuvenator can react with aged asphalt to weaken the vibration strength of carbonyl and sulfoxide groups, so as to realize the recovery of service performance. Wood tar-based rejuvenator has better environmental protection and applicability, which is worthy of further study and promotion.
Metallization and Diffusion Bonding of CoSb3-Based Thermoelectric Materials
Authors: Feng Hangbin , Zhang Lixia , Zhang Jialun , Gou Wenqin , Zhong Sujuan , Zhang Guanxing , Geng Huiyuan , Feng Jicai
Published: March 2020

CoSb3-based skutterudite alloy is one of the most promising thermoelectric materials in the middle temperature range (room temperature—550 °C). However, the realization of an appropriate metallization layer directly on the sintered skutterudite pellet is indispensable for the real thermoelectric generation application. Here, we report an approach to prepare the metallization layer and the subsequent diffusion bonding method for the high-performance multi-filled n-type skutterudite alloys. Using the electroplating followed by low-temperature annealing approaches, we successfully fabricated a Co-Mo metallization layer on the surface of the skutterudite alloy. The coefficient of thermal expansion of the electroplated layer was optimized by changing its chemical composition, which can be controlled by the electroplating temperature, current and the concentration of the Mo ions in the solution. We then joined the metallized skutterudite leg to the Cu-Mo electrode using a diffusion bonding method performed at 600 °C and 1 MPa for 10 min. The Co-Mo/skutterudite interfaces exhibit extremely low specific contact resistivity of 1.41 μΩ cm2. The metallization layer inhibited the elemental inter-diffusion to less than 11 µm after annealing at 550 °C for 60 h, indicating a good thermal stability. The current results pave the way for the large-scale fabrication of CoSb3-based thermoelectric modules.