bluuebunny/crossref_metadata_2025 huggingface dataset:
Bio-Inspired Double-Layered Hydrogel Robot with Fast Response via Thermo-Responsive Effect
Authors: Liu Yunsong , Zheng Xiong
Published: July 2024

Bio-inspired hydrogel robots have become promising due to their advantage of the interaction safety and comfort between robots and humans, while current hydrogel robots mainly focus on underwater movement due to the hydration–dehydration process of thermo-responsive hydrogels, which greatly limits their practical applications. To expand the motion of the thermo-responsive hydrogel robot to the ground, we constructed a hydrogel robot inspired by a caterpillar, which has an anisotropic double-layered structure by the interfacial diffusion polymerization method. Adding PVA and SA to PNIPAm will cause different conformation transitions. Therefore, sticking the two layers of hydrogel together will form a double-layer anisotropic structure. The ultra-high hydrophilicity of PVA and SA significantly reduces the contact angle of the hydrogel from 53.1° to about 10° and reduces its hydration time. The responsive time for bending 30° of the hydrogel robot has been greatly reduced from 1 h to half an hour through the enhancement of photo-thermal conversion and thermal conductivity via the addition of Fe3O4 nanoparticles. As a result, the fabricated hydrogel robot can achieve a high moving speed of 54.5 mm·h−1 on the ground. Additionally, the fabricated hydrogel has excellent mechanical strength and can endure significant flexibility tests. This work may pave the road for the development of soft robots and expand their applications in industry.
Evaluation of the Effect of Mineral Oil Exposure on Changes in the Structure and Mechanical Properties of Polymer Parts Produced by Additive Manufacturing Techniques
Authors: Głowacki Marcin , Skórczewska Katarzyna , Lewandowski Krzysztof , Mazurkiewicz Adam , Szewczykowski Piotr
Published: July 2024

The paper describes the type of changes in the structure and mechanical properties of 3D printed shapes under the influence of mineral oil. The effects of a room (23 °C) and elevated temperature (70 °C) on 3D prints manufactured by the FDM method and stored in oil for 15, 30, and 60 days on the change of properties and structure were investigated. The samples were produced from ABS (poly(acrylonitrile-co-butadiene-co-styrene)), ASA (poly(acrylonitrile-co-styrene-co-acrylate), PLA (poly(lactic acid)), and HIPS (high-impact polystyrene). Tests related to the strength of the materials, such as the static tensile test and Charpy impact test, were carried out. The structure was evaluated using a scanning electron microscope, and changes in chemical structure were determined by conducting FTIR (Fourier transform infrared spectroscopy) and TGA (thermogravimetric analysis) tests. The analysis of the results provided important information about the impact of mineral oil on specific materials. This is critical for designing and manufacturing components that can withstand mineral oil exposure in real-world environments. The materials underwent varying changes. Strength increased for PLA by about 28%, remained unchanged for ABS and HIPS during exposure for 30 days, and decreased for ASA with extended exposure up to 14%.
From Waste to Water Purification: Textile-Derived Sorbents for Pharmaceutical Removal
Authors: Mazur Magdalena , Shirvanimoghaddam Kamyar , Paul Moon , Naebe Minoo , Klepka Tomasz , Sokołowski Artur , Czech Bożena
Published: July 2024

The presence of pharmaceuticals or their active metabolites in receiving waters is a sign of the inefficient removal of bioactive substrates from wastewater. Adsorption seems to be the most effective and inexpensive method of their removal. Waste management aimed at sorbents is a promising way to sustain several sustainable development goals. In the presented paper, the removal of the two most widely used drugs in the wastewater was examined. Diclofenac and carbamazepine were removed from water and wastewater using textile waste-derived sorbents. Their removal efficiency was verified by testing several process parameters such as the time of the sorption, the presence of interfering inorganic ions, the presence of dissolved organic matter, the initial pH and ionic strength of the solution, and various water matrices. The adsorption capacity was noted for diclofenac (57.1 mg/g) and carbamazepine (21.25 mg/g). The tested process parameters (pH, presence of inorganic ions, dissolved organic matter, ionic strength, water matrix) confirmed that the presented waste materials possessed a great potential for pharmaceutical removal from water matrices.
Modeling of Material Removal Rate for the Fixed-Abrasive Double-Sided Planetary Grinding of a Sapphire Substrate
Authors: Chen Gen , Hu Zhongwei , Wang Lijuan , Chen Yue
Published: July 2024

Double-sided planetary grinding (DSPG) with a fixed abrasive is widely used in sapphire substrate processing. Compared with conventional free abrasive grinding, it has the advantages of high precision, high efficiency, and environmental protection. In this study, we propose a material removal rate (MRR) model specific to the fixed-abrasive DSPG process for sapphire substrates, grounded in the trajectory length of abrasive particles. In this paper, the material removal rate model is obtained after focusing on the theoretical analysis of the effective number of abrasive grains, the indentation depth of a single abrasive grain, the length of the abrasive grain trajectory, and the groove repetition rate. To validate this model, experiments were conducted on sapphire substrates using a DSPG machine. Theoretical predictions of the material removal rate were then juxtaposed with experimental outcomes across varying grinding pressures and rotational speeds. The trends between theoretical and experimental values showed remarkable consistency, with deviations ranging between 0.2% and 39.2%, thereby substantiating the model’s validity. Moreover, leveraging the insights from this model, we optimized the disparity in the material removal rate between two surfaces of the substrate, thereby enhancing the uniformity of the machining process across both surfaces.
Application of Annealed Bambara Starch as a Stabilizer in Ice Cream Production
Authors: Nwaogazie Faith O. , Akinwande Bolanle A. , Adebo Oluwafemi A. , Oyeyinka Samson A.
Published: July 2024

This study investigated the potential of annealed Bambara starch as a locally sourced stabilizer for ice cream, aimed at addressing the high cost of imported stabilizers. Annealed Bambara starch, modified at various temperatures (45, 50, 55, and 60 °C), was incorporated into ice cream formulations and compared with ice cream stabilized using xanthan gum and guar gum. The ice creams exhibited variations in percentage overrun (77.03–124.61%), foam stability (90.88–96.61%), viscosity (24.87–33.26%), and melting resistance. Conventionally stabilized ice cream outperformed in overrun, foam stability, viscosity, and melting rate properties. Descriptive sensory tests showed high intensity scores for color, aroma, taste, mouthfeel, and body attributes across all samples, with no weak intensity scores. Considering the performance of conventionally stabilized ice cream, those stabilized with Bambara starch annealed at 45 and 50 °C were recommended as potential alternatives, highlighting the potential of annealed Bambara starch as a cost-effective and locally sourced stabilizer for ice cream. Further studies should investigate the impact of annealing at different temperatures on the structural changes of Bambara starch to gain more insights into its effects on ice cream structure, facilitating its use in other food systems.
Comment on Novozhilova et al. More Capable, Less Benevolent: Trust Perceptions of AI Systems across Societal Contexts. Mach. Learn. Knowl. Extr. 2024, 6, 342–366
Authors: Damaševičius Robertas
Published: July 2024

The referenced article [...]
Reply to Damaševičius, R. Comment on “Novozhilova et al. More Capable, Less Benevolent: Trust Perceptions of AI Systems across Societal Contexts. Mach. Learn. Knowl. Extr. 2024, 6, 342–366”
Authors: Novozhilova Ekaterina , Mays Kate , Paik Sejin , Katz James
Published: July 2024

We would like to thank Dr [...]
Assessing the Value of Transfer Learning Metrics for Radio Frequency Domain Adaptation
Authors: Wong Lauren J. , Muller Braeden P. , McPherson Sean , Michaels Alan J.
Published: July 2024

The use of transfer learning (TL) techniques has become common practice in fields such as computer vision (CV) and natural language processing (NLP). Leveraging prior knowledge gained from data with different distributions, TL offers higher performance and reduced training time, but has yet to be fully utilized in applications of machine learning (ML) and deep learning (DL) techniques and applications related to wireless communications, a field loosely termed radio frequency machine learning (RFML). This work examines whether existing transferability metrics, used in other modalities, might be useful in the context of RFML. Results show that the two existing metrics tested, Log Expected Empirical Prediction (LEEP) and Logarithm of Maximum Evidence (LogME), correlate well with post-transfer accuracy and can therefore be used to select source models for radio frequency (RF) domain adaptation and to predict post-transfer accuracy.
Exploring Commutativity via Generalized (α, β)-Derivations Involving Prime Ideals
Authors: Alsowait Nawaf , Al-omary Radwan M. , Al-Amery Zakia , Al-Shomrani Mohammed
Published: July 2024

The purpose of this article is to enhance the previous studies regarding the behavior of a quotient ring ℑ/℘, where ℘ is a prime ideal in a ring ℑ. In particular, we are going to explore more general scenarios whenever a ring ℑ admits a generalized (α,β)-derivation associated with an (α,β)-derivation ∂ that satisfies certain criteria involving ℘, where α and β are automorphisms on ℑ. Moreover, we provide some examples to demonstrate the importance of the assumptions made in our results.
A Systematic Review Evaluating the Diagnostic Efficacy of Narrow-Band Imaging for Laryngeal Cancer Detection
Authors: Sanda Ileana Alexandra , Hainarosie Razvan , Ionita Irina Gabriela , Voiosu Catalina , Ristea Marius Razvan , Zamfir Chiru Anton Adina
Published: July 2024

Background: Narrow-band imaging is an advanced endoscopic technology used to detect changes on the laryngeal tissue surface, employing a comparative approach alongside white-light endoscopy to facilitate histopathological examination. Objective: This study aimed to assess the utility and advantages of NBI (narrow-band imaging) in identifying malignant laryngeal lesions through a comparative analysis with histopathological examination. Methods: We conducted a systematic literature review, utilizing databases such as PubMed, the CNKI database, and Embase for our research. Results: We analyzed the articles by reviewing their titles and abstracts, selecting those we considered relevant based on determined criteria; in the final phase, we examined the relevant studies according to the specific eligibility criteria. Conclusions: Narrow-band imaging is an advanced endoscopic technology that demonstrates its efficacy as a tool for diagnosing malignant laryngeal lesions and comparing them to premalignant lesions. The European Society of Laryngology has implemented a standardized classification system for laryngeal lesions to enhance data correlation and organization.
Finite Element Modeling and Experimental Verification of a New Aluminum Al-2%Cu-2%Mn Alloy Hot Cladding by Flat Rolling
Authors: Koshmin Alexander , Zinoviev Alexander , Cherkasov Stanislav , Mahmoud Alhaj Ali Abdullah , Tsydenov Kirill , Churyumov Alexander
Published: July 2024

The roll bonding of an experimental Al-2%Cu-2%Mn alloy with technically pure 1050A aluminum at true deformations of 0.26, 0.33 and 0.40 has been simulated using the QForm 10.3.0 FEM software. The flow stress of the Al-2%Cu-2%Mn alloy has been measured in temperature and strain rate ranges of 350–450 °C and 0.1–20 s−1, respectively. The simulation results suggest that the equivalent strain in the cladding layer is more intense than that in the base layer, reaching 1.0, 1.4 and 2.0 at strains of 0.26, 0.33 and 0.40, respectively. The latter fact favors a decrease in the difference between the flow stresses of the rolled sheet layer contact surfaces by an average of 25% at the highest strain. The experimental roll bonding has achieved good layer adhesion for all the test samples. The average peeling strength of the samples produced at strains of 0.26 and 0.33 proves to be 12.6 and 18.4 N/mm, respectively, and at a strain of 0.40, it has exceeded the flow stress of the 1050A alloy cladding layer. The change in the rolling force for different rolling routes has demonstrated the best fit with the experimental data.
Charge Trapping and Emission during Bias Temperature Stressing of Schottky Gate GaN-on-Silicon HEMT Structures Targeting RF/mm Wave Power Amplifiers
Authors: O’Sullivan Barry , Rathi Aarti , Alian Alireza , Yadav Sachin , Yu Hao , Sibaja-Hernandez Arturo , Peralagu Uthayasankaran , Parvais Bertrand , Chasin Adrian , Collaert Nadine
Published: July 2024

For operation as power amplifiers in RF applications, high electron mobility transistor (HEMT) structures are subjected to a range of bias conditions, applied at both the gate and drain terminals, as the device is biased from the OFF- to ON-state conditions. The stability of the device threshold voltage (Vt) condition is imperative from a circuit-design perspective and is the focus of this study, where stresses in both the ON and OFF states are explored. We see rapid positive threshold voltage increases under negative bias stress and subsequent recovery (i.e., Vt reduces), whereas conversely, we see a negative Vt shift under positive stress and Vt increase during the subsequent relaxation phase. These effects are correlated with the thickness of the GaN layer and ultimately result from the deep carbon-acceptor levels in the C-GaN back barrier incorporated to screen the buffer between the silicon substrate and the epitaxially grown GaN layer. Methods to mitigate this effect are explored, and the consequences are discussed.
Design and Fabrication of Continuous Surface Optical Field Modulator for Angular Spectrum Discreteness Compensation
Authors: Xiao Min , Cao Axiu , Xu Cheng , Pang Hui , Fu Yongqi , Deng Qiling
Published: July 2024

The light homogenizing element is a crucial component of the illumination system of the lithography machine. Its primary purpose is to realize the uniform distribution of energy. However, it suffers from a common issue, which is angular spectrum discreteness, which significantly impacts light uniformity. To address this, we design and fabricate random micro-cylindrical lens arrays to obtain a small-angle Gaussian optical field, which can compensate for the angular spectrum discreteness. By adjusting the pitches and curvature radii of the micro-cylindrical lenses separately, we are able to manipulate the divergence angle of the emitted sub-beams, enabling precise angular spectrum modulation. By using mask-moving technology, the angular spectrum modulator is fabricated to generate a Gaussian illumination field. The surface profile is measured and determined with a structural roughness below 10 nm. Furthermore, optical test experiments on the modulator have been conducted, achieving an angle error of less than 0.02° and a balance better than 0.5%.
A Comparative Study of Methods for Calculating the Dislocation Density in GaN-on-Si Epitaxial Wafers
Authors: Yan Yujie , Huang Jun , Pan Lei , Meng Biao , Wei Qiangmin , Yang Bing
Published: July 2024

A series of characterization methods involving high-resolution X-ray diffraction (HR-XRD), electron channel contrast imaging (ECCI), cathodoluminescence microscopy (CL), and atomic force microscopy (AFM) were applied to calculate the dislocation density of GaN-on-Si epitaxial wafers, and their performance was analyzed and evaluated. The ECCI technique, owing to its high lateral resolution, reveals dislocation distributions on material surfaces, which can visually characterize the dislocation density. While the CL technique is effective for low-density dislocations, it is difficult to accurately identify the number of dislocation clusters in CL images as the density increases. The AFM technique analyzes surface dislocation characteristics by detecting surface pits caused by dislocations, which are easily affected by sample and probe conditions. A prevalent method for assessing the crystal quality of GaN is the rocking curve of HR-XRD (ω-scan), which calculates the dislocation density based on the FWHM value of the curves. By comparing the above four dislocation characterization methods, the advantages and limitations of each method are clarified, which also verifies the applicability of DB=β29b2 for GaN-on-Si epitaxial wafers. This provides an important reference value for dislocation characterization in GaN-on-Si materials. The accuracy evaluation of dislocation density can truly and reliably reflect crystal quality, which is conducive to further optimization. Furthermore, this study can also be applied to other heterogeneous or homogeneous epitaxial materials.
Modulation of the Toll-like Receptor 3-Mediated Intestinal Immune Response by Water Kefir
Authors: Dentice Maidana Stefania , Ortiz Moyano Ramiro , Elean Mariano , Imamura Yoshiya , Albarracín Leonardo , Namai Fu , Suda Yoshihito , Nishiyama Keita , Villena Julio , Kitazawa Haruki
Published: July 2024

Kefir has been associated with beneficial effects on its host’s health. The previous works examining the impact of kefir on the immune system focused on milk kefir or the exopolysaccharides and bacterial strains derived from it, while water kefir has not been evaluated. Furthermore, studies have focused on kefir’s ability to modulate immune system hemostasis and exert anti-inflammatory effects, while its specific action on antiviral immunity has not been investigated. Thus, the aim of this work was to examine the potential immunomodulatory effects of water kefir on the intestinal innate antiviral immunity mediated by Toll-like receptor-3 (TLR3). Adult BALB/c mice fed water kefir ad libitum, diluted 1:5, 1:10, or 1:20 in the drinking water, for 6 consecutive days. On day 7, the treated groups and the untreated control mice received an intraperitoneal injection of the TLR3 agonist poly(I:C). Two days after the TLR3 activation, the intestinal damage and the innate immune response were studied. The intraperitoneal administration of poly(I:C) induced inflammatory-mediated intestinal tissue damage, characterized by the upregulation of interferons (IFNs), pro-inflammatory mediators (TNF-α, IL-15, IL-6), and factors involved in epithelial destruction (RAE-1 and NKG2D). The histological analysis of small intestinal samples showed that mice receiving water kefir 1:5 exhibited reduced edema and a lower inflammatory cell infiltration. Kefir-treated mice had significantly lower levels of serum LDH, AST, and ALT as well as intestinal TNF-α, IL-15, IL-6, RAE-1, and NKG2D. This group also showed higher concentrations of intestinal IFN-β, IFN-γ, and IL-10. The treatment with 1:10 of water kefir reduced intestinal damage and modulated cytokines but its effect was significantly lower than the 1:5 treatment, while the water kefir 1:20 did not modify the parameters evaluated compared to control mice. The results indicate that water kefir exerts its immunomodulatory effects in a dose-dependent manner. The in vivo studies allow us to speculate that water kefir can induce two beneficial effects on the intestinal TLR3-mediated immune response: the enhancement of antiviral defenses and the protection against the inflammatory-mediated tissue damage. These protective effects of water kefir require further exploration to understand how water kefir, or its specific molecules/strains, can influence the immune response and to determine the extent of its protection against a real viral challenge.
Geochemical Features, Origin, and Depositional Environment of Late Ordovician–Early Silurian Wufeng and Longmaxi Formation Cherts in the Southeastern Sichuan Basin
Authors: Ge Xiangying , Mou Chuanlong , Men Xin , Wang Qiyu , Hou Qian , Zheng Binsong , Chen Feifei
Published: July 2024

The Sichuan Basin in Southeastern China contains extensive bedded cherts dating back to the Late Ordovician–Early Silurian period. To investigate the origin and depositional environment of these cherts, we conducted a comprehensive study using field observations, thin sections microscopic, silicon isotope analysis, and major and trace element geochemistry of samples from three sections. Our results indicate that the cherts from Wufeng and Longmaxi formations are non-hydrothermal, normal biogenic seawater deposits mainly affected by terrigenous input and slightly associated with volcanic ash. Al2O3/(Al2O3 + Fe2O3T) and LaN/CeN ratios, δCe values and Fe2O3T/TiO2 − Al2O3/(Al2O3 + Fe2O3T), Fe2O3T/(100 − SiO2) − Al2O3/(100 − SiO2), 100 × (Fe2O3T/SiO2) – 100 × (Al2O3/SiO2), and LaN/CeN − Al2O3/(Al2O3 + Fe2O3T) discrimination diagrams indicated that the bedded cherts deposited in the continental margin environment.
Experimental Investigation of Recycling Cement Kiln Dust (CKD) as a Co-Binder Material in Cemented Paste Backfill (CPB) Made with Copper Tailings
Authors: Al-Bakri Ali Y. , Ahmed Haitham M. , Hefni Mohammed A.
Published: July 2024

Cement production may involve excessive use of natural resources and have negative environmental impacts, as energy consumption and CO2 emissions can cause air pollution and climate change. Cement kiln dust (CKD), a by-product waste material, is also a primary issue associated with cement production. Utilizing CKD in mining applications is a pathway to eco-sustainable solutions. Cemented paste backfill (CPB) made with mine tailings is an efficient method for void backfilling in underground mines. Therefore, this study investigated the eco-sustainable utilization of CKD as a co-binder material that can partially replace cement in CPB prepared with copper tailings. At 7, 14, 28, 56, and 90-day curing times, the experimental campaign measured the physical and mechanical parameters of the cured CPB samples, including density, UCS, and elastic modulus (stiffness). Additionally, the CPB-cured mixes were analyzed using XRF, X-ray XRD, SEM, and EDX techniques to link the mineral phases and microstructure to mechanical performance. Four proportions (5, 10, 15, and 20%) of CKD represented in 75 samples were prepared to replace ordinary Portland cement (OPC) in the CPB mixtures, in addition to the reference mix (control) with 0% CKD. As all combinations exceed the compressive strength of CPB required for achieving stability in underground mines, the results showed that CKD could be utilized advantageously as a partial substitute for OPC with a proportion of up to 20% in the CPB mixture. When tested after 90 days, the combination modified with 5% CKD exhibited comparatively higher compressive strength than the control mixture.
Comparative Proteomics and Metabonomics Analysis of Different Diapause Stages Revealed a New Regulation Mechanism of Diapause in Loxostege sticticalis (Lepidoptera: Pyralidae)
Authors: Shao Lijun , Yue Fangzheng , Fan Jinfu , Su Qin , Liu Hairui , Zhang Quanyi , Xu Linbo
Published: July 2024

Histone acetylation is an important epigenetic mechanism that has been shown to play a role in diapause regulation. To explore the physiological and molecular mechanisms of histone deacetylase in the diapause process, LC-MS/MS analysis was used to perform TMT proteomic and metabolomic analysis on non-diapause (ND), pre-diapause (PreD), diapause (D), cold treatment (CT), and post-diapause (RD) stages of the meadow moth. A total of 5367 proteins were identified by proteomics, including 1179 differentially expressed proteins. We found 975 (602 up-regulated and 373 down-regulated), 997 (608 up-regulated and 389 down-regulated), 1119 (726 up-regulated and 393 down-regulated), 1179 (630 up-regulated and 549 down-regulated), 94 (51 up-regulated and 43 down-regulated), 111 (63 up-regulated and 48 down-regulated), 533 (243 up-regulated and 290 down-regulated), 58 (31 up-regulated and 27 down-regulated), and 516 (228 up-regulated and 288 down-regulated) proteins in ND and PreD, ND and D, ND and CT, ND and RD, PreD and D, PreD and CT, PreD and RD, D and CT, D and RD, and CT and RD stages, respectively. A total of 1255 differentially expressed metabolites were annotated by metabolomics. Through KEGG analysis and time series analysis of differentially expressed metabolites, we found that phospholipids were annotated in significantly different modules, demonstrating their important role in the diapause process of the meadow moth. Using phospholipids as an indicator for weighted gene co-expression network analysis, we analyzed the most relevant differentially expressed proteins in the module and found that ribosomal 40s and 60s subunits were the most relevant proteins for diapause. Because there have been studies that have shown that histone deacetylase is associated with the diapause of meadow moths, we believe that histone deacetylase regulates the 40s and 60s subunits of ribosomes, which in turn affects the diapause of meadow moths. This finding expands our understanding of the regulation of meadow moth diapause and provides new insights into its control mechanism.
Asymmetric Sulfoxidations Catalyzed by Bacterial Flavin-Containing Monooxygenases
Authors: de Gonzalo Gonzalo , Coto-Cid Juan M. , Lončar Nikola , Fraaije Marco W.
Published: July 2024

Flavin-containing monooxygenase from Methylophaga sp. (mFMO) was previously discovered to be a valuable biocatalyst used to convert small amines, such as trimethylamine, and various indoles. As FMOs are also known to act on sulfides, we explored mFMO and some mutants thereof for their ability to convert prochiral aromatic sulfides. We included a newly identified thermostable FMO obtained from the bacterium Nitrincola lacisaponensis (NiFMO). The FMOs were found to be active with most tested sulfides, forming chiral sulfoxides with moderate-to-high enantioselectivity. Each enzyme variant exhibited a different enantioselective behavior. This shows that small changes in the substrate binding pocket of mFMO influence selectivity, representing a tunable biocatalyst for enantioselective sulfoxidations.
Recent Advances in Regulating Ceramic Monolithic Catalyst Structure for Preferential Oxidation of CO in H2
Authors: Wang Qing , Sui Jiancai , Li Linlin , Tuo Yongxiao , Zhang Wenfa , Zhong Guoyu , Zhou Huanxin , Feng Xiang
Published: July 2024

Preferential oxidation of CO (CO-PROX) has tremendous significance in purifying hydrogen for fuel cells to avoid catalyst poisoning by CO molecules. Traditional powder catalysts face numerous challenges, including high pressure drop, aggregation tendency, hotspot formation, poor mass and heat transfer efficiency, and inadequate thermal stability. Accordingly, ceramic monolithic catalysts, known as their excellent thermal stability, high surface area, and superior mass and heat transfer characteristics, are gaining increasing research attention. This review examines recent studies on ceramic monolithic catalysts in CO-PROX, placing emphasis on the regulation of active sites (e.g., precious metals like Pt and Au, and non-precious metals like CuO and CeO2), monolith structures, and coating strategies. In addition, the structure–catalytic performance relationships, as well as the potential and limitations of different ceramic monolithic catalysts in practical application, are discussed. Finally, the challenges of monolithic catalysts and future research prospects in CO-PROX reactions are highlighted.
Structural Unfolding of G-Quadruplexes: From Small Molecules to Antisense Strategies
Authors: Fracchioni Giorgia , Vailati Sabrina , Grazioli Marta , Pirota Valentina
Published: July 2024

G-quadruplexes (G4s) are non-canonical nucleic acid secondary structures that have gathered significant interest in medicinal chemistry over the past two decades due to their unique structural features and potential roles in a variety of biological processes and disorders. Traditionally, research efforts have focused on stabilizing G4s, while in recent years, the attention has progressively shifted to G4 destabilization, unveiling new therapeutic perspectives. This review provides an in-depth overview of recent advances in the development of small molecules, starting with the controversial role of TMPyP4. Moreover, we described effective metal complexes in addition to G4-disrupting small molecules as well as good G4 stabilizing ligands that can destabilize G4s in response to external stimuli. Finally, we presented antisense strategies as a promising approach for destabilizing G4s, with a particular focus on 2′-OMe antisense oligonucleotide, peptide nucleic acid, and locked nucleic acid. Overall, this review emphasizes the importance of understanding G4 dynamics as well as ongoing efforts to develop selective G4-unfolding strategies that can modulate their biological function and therapeutic potential.
The Influence of Zinc Oxide and Zinc Stearate on the Antimicrobial Activity of Coatings Containing Raspberry and Chokeberry Extracts
Authors: Mizielińska Małgorzata , Bartkowiak Artur
Published: July 2024

The goal of this research was to analyse the synergistic effect between selected plant extracts with zinc oxide particles, and zinc stearate. The influence of ZnO on the antimicrobial effectiveness of the selected extracts was confirmed in previous research carried out by the authors. However, the impact of zinc stearate on extract activity has yet to be analysed. The aim was to cover PLA films with active coatings based on hydroxy-propyl-methyl-cellulose (HPMC), or/and ethyl cellulose (EC) containing plant extracts and ZnO which has a synergistic effect. An additional aim was to use a CO2 extract of raspberry seed (RSE) with zinc stearate as active additives within the coatings. An examination of the antimicrobial properties (against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas syringae and Φ6 bacteriophage) of the covered films, as well as an investigation of layer presence with regards to PLA morphology (SEM, ATR-FTIR analysis) was carried out. The research work that was performed indicated that black chokeberry extract (ChE) and zinc oxide particles were effective against S. aureus, P. syringae and B. subtilis strains. In addition, the ChE with zinc stearate (ZnSt) was active against all analysed strains. The HPMC with ChE and ZnO as additives had antimicrobial properties against S. aureus, P. syringae and E. coli strains. The ChE was found to inhibit the growth of all of the analysed bacterial strains. When considering the coatings based on EC with the CO2 extract of raspberry seed (RSE) and ZnO, it was noted that they were only active against Gram-negative bacteria. The results of the experiments confirmed that AC1 (EC with RSE with ZnO) and AC2 (EC with RSE with ZnSt) coatings were not active against a phi6 bacteriophage. The HPMC coating containing the AC3 layer (ChE and ZnO) eliminated Φ6 particles, confirming its antiviral properties. In addition, the presence of the active (AC1, AC2 and AC3) coatings was confirmed by SEM and FTIR analysis.
Exploring the Potential of Microbial Coalbed Methane for Sustainable Energy Development
Authors: Niu Yu , Wang Zhiqian , Xiong Yingying , Wang Yuqi , Chai Lin , Guo Congxiu
Published: July 2024

By allowing coal to be converted by microorganisms into products like methane, hydrogen, methanol, ethanol, and other products, current coal deposits can be used effectively, cleanly, and sustainably. The intricacies of in situ microbial coal degradation must be understood in order to develop innovative energy production strategies and economically viable industrial microbial mining. This review covers various forms of conversion (such as the use of MECoM, which converts coal into hydrogen), stresses, and in situ use. There is ongoing discussion regarding the effectiveness of field-scale pilot testing when translated to commercial production. Assessing the applicability and long-term viability of MECoM technology will require addressing these knowledge gaps. Developing suitable nutrition plans and utilizing lab-generated data in the field are examples of this. Also, we recommend directions for future study to maximize methane production from coal. Microbial coal conversion technology needs to be successful in order to be resolved and to be a viable, sustainable energy source.
Enhancing Cellulose and Lignin Fractionation from Acacia Wood: Optimized Parameters Using a Deep Eutectic Solvent System and Solvent Recovery
Authors: Magalhães Solange , Aliaño-González María José , Rodrigues Mariana , Fernandes Catarina , Mendes Cátia V. T. , Carvalho Maria Graça V. S. , Alves Luís , Medronho Bruno , Rasteiro Maria da Graça
Published: July 2024

Cellulose and lignin, sourced from biomass, hold potential for innovative bioprocesses and biomaterials. However, traditional fractionation and purification methods often rely on harmful chemicals and high temperatures, making these processes both hazardous and costly. This study introduces a sustainable approach for fractionating acacia wood, focusing on both cellulose and lignin extraction using a deep eutectic solvent (DES) composed of choline chloride (ChCl) and levulinic acid (LA). A design of experiment was employed for the optimization of the most relevant fractionation parameters: time and temperature. In the case of the lignin, both parameters were found to be significant variables in the fractionation process (p-values of 0.0128 and 0.0319 for time and temperature, respectively), with a positive influence. Likewise, in the cellulose case, time and temperature also demonstrated a positive effect, with p-values of 0.0103 and 0.028, respectively. An optimization study was finally conducted to determine the maximum fractionation yield of lignin and cellulose. The optimized conditions were found to be 15% (w/v) of the wood sample in 1:3 ChCl:LA under a treatment temperature of 160 °C for 8 h. The developed method was validated through repeatability and intermediate precision studies, which yielded a coefficient of variation lower than 5%. The recovery and reuse of DES were successfully evaluated, revealing remarkable fractionation yields even after five cycles. This work demonstrates the feasibility of selectively extracting lignin and cellulose from woody biomass using a sustainable solvent, thus paving the way for valorization of invasive species biomass.
PRKAG2 Variant, Motor Neuron Disease, and Parkinsonism: Fortuitous Association or a Potentially Underestimated Pathophysiological Mechanism?
Authors: Orsini Marco , Pinto Wladimir Bocca Vieira de Rezende , Sgobbi Paulo , Oliveira Acary Souza Bulle
Published: July 2024

A 72-year-old Brazilian woman presented with a 4-year history of rest tremors of the hands, followed by slowness of movement, and a diagnosis of idiopathic Parkinson’s disease. She was started on dopamine agonists with significant improvement. After three years, she complained about slowly progressive dysphagia, dysphonia, quadriparesis, and cramps and fasciculations. A neurological examination disclosed distal-dominant quadriparesis, dysarthria, atrophy and fasciculation of the tongue, global brisk tendon reflexes, fasciculations, bilateral ankle clonus, and moderate spasticity of the lower limbs. She had also palpitations, dyspnea, and one episode of paroxysmal atrial fibrillation. Electrocardiography revealed a short PR interval, a widened QRS complex, and the delta wave, suggestive of Wolff–Parkinson–White syndrome. Brain and spine MR imaging, a cerebrospinal fluid analysis, and general serum lab exams were unremarkable. Needle electromyography disclosed chronic denervation involving cervical, thoracic, lumbosacral, and bulbar levels associated with acute denervation, including positive sharp waves, fasciculations, and fibrillation potentials. This patient fulfilled the diagnostic criteria for amyotrophic lateral sclerosis associated with parkinsonism. A broad next-generation sequencing-based panel disclosed the presence of the novel heterozygous variant c.1247C > T (p.Pro416Leu) in the PRKAG2 gene (NM_016203.4). Clinicians must be aware of the possibility of PRKAG2 variants in complex clinical scenarios associating cardiac arrhythmia, preexcitation syndromes, hypertrophic cardiomyopathy, motor neuron disease, and parkinsonism.
Josephson Diode Effect in Parallel-Coupled Double-Quantum Dots Connected to Unalike Majorana Nanowires
Authors: Gao Yu-Mei , Xiao Hu , Jiang Mou-Hua , Chi Feng , Yi Zi-Chuan , Liu Li-Ming
Published: July 2024

We study theoretically the Josephson diode effect (JDE) when realized in a system composed of parallel-coupled double-quantum dots (DQDs) sandwiched between two semiconductor nanowires deposited on an s-wave superconductor surface. Due to the combined effects of proximity-induced superconductivity, strong Rashba spin–orbit interaction, and the Zeeman splitting inside the nanowires, a pair of Majorana bound states (MBSs) may possibly emerge at opposite ends of each nanowire. Different phase factors arising from the superconductor substrate can be generated in the coupling amplitudes between the DQDs and MBSs prepared at the left and right nanowires, and this will result in the Josephson current. We find that the critical Josephson currents in positive and negative directions are different from each other in amplitude within an oscillation period with respect to the magnetic flux penetrating through the system, a phenomenon known as the JDE. It arises from the quantum interference effect in this double-path device, and it can hardly occur in the system of one QD coupled to MBSs. Our results also show that the diode efficiency can reach up to 50%, but this depends on the overlap amplitude between the MBSs, as well as the energy levels of the DQDs adjustable by gate voltages. The present model is realizable within current nanofabrication technologies and may find practical use in the interdisciplinary field of Majorana and Josephson physics.
A User Location Reset Method through Object Recognition in Indoor Navigation System Using Unity and a Smartphone (INSUS)
Authors: Fajrianti Evianita Dewi , Panduman Yohanes Yohanie Fridelin , Funabiki Nobuo , Haz Amma Liesvarastranta , Brata Komang Candra , Sukaridhoto Sritrusta
Published: July 2024

To enhance user experiences of reaching destinations in large, complex buildings, we have developed a indoor navigation system using Unity and a smartphone called INSUS. It can reset the user location using a quick response (QR) code to reduce the loss of direction of the user during navigation. However, this approach needs a number of QR code sheets to be prepared in the field, causing extra loads at implementation. In this paper, we propose another reset method to reduce loads by recognizing information of naturally installed signs in the field using object detection and Optical Character Recognition (OCR) technologies. A lot of signs exist in a building, containing texts such as room numbers, room names, and floor numbers. In the proposal, the Sign Image is taken with a smartphone, the sign is detected by YOLOv8, the text inside the sign is recognized by PaddleOCR, and it is compared with each record in the Room Database using Levenshtein distance. For evaluations, we applied the proposal in two buildings in Okayama University, Japan. The results show that YOLOv8 achieved mAP@0.5 0.995 and mAP@0.5:0.95 0.978, and PaddleOCR could extract text in the sign image accurately with an averaged CER% lower than 10%. The combination of both YOLOv8 and PaddleOCR decreases the execution time by 6.71s compared to the previous method. The results confirmed the effectiveness of the proposal.
Multiple Administration of Dexamethasone Possesses a Deferred Long-Term Effect to Glycosylated Components of Mouse Brain
Authors: Aladev Stanislav D. , Sokolov Dmitry K. , Strokotova Anastasia V. , Kazanskaya Galina M. , Volkov Alexander M. , Aidagulova Svetlana V. , Grigorieva Elvira V.
Published: July 2024

Glucocorticoids are used during glioblastoma treatment to prevent the cerebral edema effect surrounding normal brain tissue. The aim of our study was to investigate the long-term effects of multiple administrations of glucocorticoids onto the glycosylated components (proteoglycans and glycosaminoglycans) of normal brain extracellular matrix and the glucocorticoid receptor (GR, Nr3c1) in an experimental model in vivo. Two-month-old male C57Bl/6 mice (n = 90) were injected intraperitoneally with various doses of dexamethasone (DXM) (1; 2.5 mg/kg) for 10 days. The mRNA levels of the GR, proteoglycans core proteins, and heparan sulfate metabolism-involved genes were determined at the 15th, 30th, 60th, and 90th days by a real-time RT–PCR. The glycosaminoglycans content was studied using dot blot and staining with Alcian blue. A DXM treatment increased total GAG content (2-fold), whereas the content of highly sulfated glycosaminoglycans decreased (1.5–2-fold). The mRNA level of the heparan sulfate metabolism-involved gene Hs3St2 increased 5-fold, the mRNA level of Hs6St2 increased6–7-fold, and the mRNA level of proteoglycan aggrecan increased 2-fold. A correlation analysis revealed an association between the mRNA level of the GR and the mRNA level of 8 of the 14 proteoglycans-coding and 4 of the 13 heparan sulfate metabolism-involved genes supporting GR involvement in the DXM regulation of the expression of these genes. In summary, multiple DXM administrations led to an increase in the total GAG content and reorganized the brain extracellular matrix in terms of its glycosylation pattern.
Continuous Research of Headache and Migraine
Authors: Shibata Yasushi
Published: July 2024

Headache is a common disorder with high prevalence [...]
Drivers and Barriers Influencing Adherence to the Mediterranean Diet: A Comparative Study across Five Countries
Authors: Biggi Chiara , Biasini Beatrice , Ogrinc Nives , Strojnik Lidija , Endrizzi Isabella , Menghi Leonardo , Khémiri Ikram , Mankai Amani , Slama Fethi Ben , Jamoussi Henda , Riviou Katerina , Elfazazi Kaoutar , Rehman Nayyer , Scazzina Francesca , Menozzi Davide
Published: July 2024

Given the global decline in adherence to the Mediterranean Diet (MD), even within its native region, it is key to identify the factors influencing this trend to mitigate the negative health outcomes associated with westernized diets. To this end, 4025 individuals (49.6% women, 42.6 ± 14.2 y/o) from Greece, Italy, Morocco, Slovenia, and Tunisia remotely completed a series of measures assessing motives, attitudes, and psychosocial factors related to MD adherence, which was evaluated using the MEDAS questionnaire. The results suggested medium-to-low adherence across all countries, with the highest adherence in Italy and Morocco and the lowest in Slovenia. Structural equation modeling revealed that positive attitudes toward the healthiness of food were the strongest predictors of adherence, whereas picky eating was a significant negative predictor in all countries except Greece. Adherence to the MD was positively influenced by health motivations in Morocco and weight control in Slovenia and Greece, while sensory appeal negatively influenced adherence in Italy. Additionally, price and convenience were significant barriers in Tunisia and Greece, whereas a preference for local and seasonal foods promoted adherence in Morocco and Greece. Overall, our findings underscore the need for country-specific interventions and policies that address distinct local factors and motivations to ease favorable shifts in dietary patterns toward MD principles.
Assessment of Diet Quality Based on Selected Dietary Quality Indices and Consumption of Specific Food Items of Midwives Working on a Shift Schedule in Wroclaw, Poland
Authors: Gołąbek Katarzyna Daria , Chmielewska Anna , Karoluk Ewa , Kujawa Krzysztof , Regulska-Ilow Bożena
Published: July 2024

The aim of this study was to assess the quality of diets among midwives working in a shift system and to analyze variations in their dietary habits according to their working hours. In a group of fifty midwives employed in four public hospitals in Wrocław, the HDI-2015, HEI-2015, AHEI-2010, and Mellen’s DASH diet index were calculated. The significance of differences in terms of the prevalence of selected dietary habits, meal frequency, average content of selected food items, and the percentage of energy obtained from them was assessed. Over half of the diets of the participants exhibited low adherence to the selected dietary indices. Only the scores on Mellen’s DASH diet index were significantly associated with other components of the diet. Diets scoring ≥ 4.5 points were characterized by significantly lower processed meat content, meal frequency, and energy value, as well as lower sugar content and lower dietary energy value, compared to diets scoring < 4.5 points. Regardless of their working hours, the diets of midwives are characterized by low quality. Therefore, it appears essential to introduce targeted educational programs and provide guidance on appropriate dietary models, such as the DASH diet.
Association of Beverage Consumption during Pregnancy with Adverse Maternal and Offspring Outcomes
Authors: Wang Zhengyuan , Cui Xin , Yu Huiting , Chan Ee-Mien , Shi Zehuan , Shi Shuwen , Shen Liping , Sun Zhuo , Song Qi , Lu Wei , Ma Wenqing , Mai Shupeng , Zang Jiajie
Published: July 2024

Background: As the global consumption of sugary and non-sugar sweetened beverages continues to rise, there is growing concern about their health impacts, particularly among pregnant women and their offspring. Objective: This study aimed to investigate the consumption patterns of various beverages among pregnant women in Shanghai and their potential health impacts on both mothers and offspring. Method: We applied a multi-stage random sampling method to select participants from 16 districts in Shanghai. Each district was categorised into five zones. Two towns were randomly selected from each zone, and from each town, 30 pregnant women were randomly selected. Data were collected through face-to-face questionnaires. Follow-up data on births within a year after the survey were also obtained. Result: The consumption rates of total beverages (TB), sugar-sweetened beverages (SSB), and non-sugar sweetened beverages (NSS) were 73.2%, 72.8%, and 13.5%, respectively. Logistic regression analysis showed that compared to non-consumers, pregnant women consuming TB three times or less per week had a 38.4% increased risk of gestational diabetes mellitus (GDM) (OR = 1.384; 95% CI: 1.129–1.696) and a 64.2% increased risk of gestational hypertension (GH) (OR = 1.642; 95% CI: 1.129–2.389). Those consuming TB four or more times per week faced a 154.3% higher risk of GDM (OR = 2.543; 95% CI: 2.064–3.314) and a 169.3% increased risk of GH (OR = 2.693; 95% CI: 1.773–4.091). Similar results were observed in the analysis of SSB. Regarding offspring health, compared to non-consumers, TB consumption four or more times per week was associated with a substantial increase in the risk of macrosomia (OR = 2.143; 95% CI: 1.304–3.522) and large for gestational age (LGA) (OR = 1.695; 95% CI: 1.219–2.356). In the analysis of NSS, with a significantly increased risk of macrosomia (OR = 6.581; 95% CI:2.796–13.824) and LGA (OR = 7.554; 95% CI: 3.372–16.921). Conclusion: The high level of beverage consumption among pregnant women in Shanghai needs attention. Excessive consumption of beverages increases the risk of GDM and GH, while excessive consumption of NSS possibly has a greater impact on offspring macrosomia and LGA.