bluuebunny/crossref_metadata_2025 huggingface dataset:
Beneficial Role of Mushroom in Recovering Complications of Hypercholesterolemia
Authors: Swarup Kumar Kundu  , Md. Abu Hadi Noor Ali Khan  , Shonkor Kumar Das
Published: August 2021

Mushrooms are considered as a valuable source of important nutrients having hepatoprotective and anti-hyperlipidemic actions. Present experimental research was done to explore the beneficial role of mushroom on health in hypercholesterolemia. Total thirty Swiss albino mice were taken and randomly divided into three groups: control A, group B and group C. Each group consisted of ten mice. The control A group was fed with normal mice pellet and fresh water. Group B was fed with hypercholesterolemic diet and group C was supplied hypercholesterolemic diet with mushroom powder (500g/kg/mice body weight) for 60 days. After the experimental tenure, mice of each group were sacrificed ethically and the samples (liver and blood) were collected for gross, histological study and lipid profile analysis.  Increased liver weight, pale and hemorrhagic liver in gross observation along with some histological changes including dilation and congestion of central and portal vein, fat accumulation in hepatocyte and marked lymphocytic infiltration were found in group B, while mushroom supplementation recovered this gross and histological changes and reduced liver weight in group C. Just mild congestion and dilation was in the portal vein of group C. In lipid profile analysis, total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) level significantly reduced respectively by 10%, 38% and 17% in group C than group B. High density lipoprotein (HDL) level also significantly increased by 20% in group C compared to group B. Therefore, it can be concluded that mushrooms might have potentially beneficial actions in recovering of some complications in hypercholesterolemia.
FUNCTIONS AND ROLE OF BUDGET EXPENDITURES IN ENSURING SOCIAL PROTECTION OF THE POPULATION
Authors:   Vasil Stefanyk Precarpathian National University, Borushok Ilona
Published: August 2021

In modern conditions, public spending on social protection plays a priority role in improving the welfare and quality of life of vulnerable populations. From the volume and direction of financial resources of the state depends not only the level of welfare of society, but also the development of the domestic economy and the stability of the socio-political situation in the state. The developed countries of the modern world spend about 17% of gross domestic product for social protection and social security. This indicator shows that expenditures on the social component occupy the largest share in the structure of state budget expenditures, both in foreign countries and in Ukraine. The lack of public funds to meet the requirements of current legislation and failure to fulfill planned indicators of financing of all social articles are the main problems of financial provision of social protection in Ukraine. Despite the fact that during the analyzed period there is an increase in expenditures on social protection in Ukraine, these funds are still insufficient. The implementation of the policy in the social protection system has a number of reasons, which are manifested primarily in the implementation of the approved expenditures of the state budget. Despite the significant amounts of public spending on social protection and social security and wide range of forms of social assistance, the benefits of which are enjoyed by a significant part of society, not all measures are effective. On the one hand, the state invests significant funds in the development of the social sphere, and on the other - these costs do not solve the problems of social protection, but, on the contrary, inflate them. Solving the problems of financing social protection in Ukraine must be carried out in conjunction with reforming the social protection system as a whole, which will reduce the financial burden of the state and improve living standards. Therefore, we consider it important to investigate the issues of public spending on social protection and the problems of financing the social sphere and find alternatives to improve its functioning.
PECULIARITIES OF SUBORDINATION OF LABOUR TO CAPITAL IN THE ERA OF DIGITALIZATION
Authors:   Odesa National Economic University, Shatnenko Kateryna , Viazmikina Iryna ,   Odesa National Economic University, Spaskyi Ihor ,   Secondary School "At the Crossroads"
Published: August 2021

The article raises the problem of the peculiarities of the subordination of labour to capital in the context of modern digitalization. Digitalization is recognized as a process that has a profound impact on the entire economy. Proliferation of digitalization is of great importance for the social production. Therefore, it is necessary to consider the scale of digitalization and determine its impact on the main agent of industrial relations – the workforce. The consequences of digitalization are closely linked to growing employment problems. There are many studies which assess the impact of digitalization on jobs, on the structure of the workforce. It is stressed that the workforce was pushed out of middle-income jobs, so these workers were either leaving the workforce or finding work among non-routine manual occupations with lower wages. New digital possibilities of subordination of labor to capital, forms of digital socialization, isolation and the impact of digitalization on the dynamics of labor productivity are explored. It is shown that the growth of labor productivity in the information sector did not lead to the expected growth of labor productivity in the traditional sectors of material production. In the financial sector of the economy, the development of information technology increases capital mobility, accelerates the time of its turnover, but at the same time it promotes the growth of financial bubbles and increases the instability of the financial system. Digitalization reveals two antagonistic tendencies: on the one hand – the global digital society blurs the boundaries between people of different countries, social strata, overcoming both spatial and linguistic barriers, on the other hand, there is an opposite tendency of the so-called digital isolation or loneliness, when a person is locked in the space of gadgets and at the same time existentially lonely, separated from direct interaction with other people. The development of digital technologies is not able to change the nature of capital, but on the contrary – creates new forms of subordination of hired labour to capital.
THEORETICAL AND DEFINITIVE EXHIBITION OF THE CATEGORY APPARATUS OF RESEARCH OF AGRICULTURAL SECTOR PROBLEMS
Authors: Shulha Olha
Published: August 2021

The article considers the content and ratio of essentially similar agrarian definitions, which are the basis of scientific research in the agricultural sector of the economy. It is argued that the agricultural sector is part of the national economy, where the production of agricultural products and products of its primary processing. It is concluded that the agricultural sector covers the agricultural relations between its subjects and a certain technological method of production on which they are based. It is proved that in the case of the definitions «agricultural sector», «agricultural economy» and «agricultural sector», we are talking about different approaches to the interpretation of the content of the «agricultural sector». In the first case it is a sectoral approach, in the second – structural and functional, in the third – socio-economic. Definitions of «agrarian industry», «agrarian business» and «agrarian relations» are defined. The author proves that agrarian relations are a multifaceted system of interactions of economic entities in the agricultural sector of the economy on agricultural production, reproduction of socio-demographic and labor potential of society and restoration of ecological balance in agrobiocenoses taking into account the interests of peasants, their self-determination and self-determination. based on the existing system of land ownership relations. The effectiveness of these relations largely depends on the method of combining the direct producer with the means of production and the existing economic conditions. This interpretation of the category "agrarian relations" is proposed on the basis of four basic principles: first, it is based on the structure and functions of modern agrarian relations; secondly, it retains a decisive place in the system of agrarian relations of ownership of land and human capital; thirdly, it focuses on solving specific problems of modern agrarian relations, which take place at the present stage of development of the agrarian sphere of production in the world; fourthly, it takes into account the fact that the progressive development of the agricultural sector depends, first of all, on the development of the main productive force – the agricultural producer, its intellectualization and socialization.
DEVELOPMENT OF THE INTEGRATED QUALITY MANAGEMENT SYSTEM OF AIR TRANSPORT ENTERPRISES
Authors: Simkova Tetiana , Panchoshna Tetiana
Published: August 2021

The article considers how the development of the quality management system affects the market position of air transport enterprises. The development of an integrated management system will ensure a stable level of quality of airport services, its full compliance with the established requirements, taking into account the needs of consumers, mostly airlines, to achieve maximum satisfaction, and reduce the negative impact of airports on the environment. Improving the quality management system will take into account the requirements and needs of service consumers, control the level of customer satisfaction, avoid possible mistakes in planning and performing work at each stage, regularly monitor the effectiveness of actions taken to ensure quality, and generally improve the entire enterprise , ensure coordination of requirements of buyers of services and normative documents, find and make efforts to eliminate discrepancies as soon as possible, and promptly prescribe methods to eliminate their cause and do everything possible to avoid their recurrence; manage important aspects of ecological activity of the enterprise, plan measures for environmental protection.
However, quality management has a great influence on the following processes of the enterprise: production management, project management, corporate management, investment management, personnel management, financial management. But in practice to achieve the desired quality is much more difficult than it seems. Because the appropriate managers must control all processes in production. And their work can be facilitated only by subordinates. That is, a fully covered quality improvement can be achieved only through the interest and motivation of workers at all levels.
This is confirmed by the activities of the world's leading companies, which in recent years have begun to pay more attention to corporate policy, feedback from their customers and improving production technology.
Modern production technologies are increasingly confirming that the concept of quality must be embedded in the product from the very beginning of its creation and continue its implementation at all stages of its development. That is, a comprehensive quality assurance system at the enterprise can be considered as a set of all organizational structures, processes, measures and techniques for its improvement, as well as stakeholders.
Therefore, this article will also consider how global international quality standards have changed, in particular the ISO 9001 series over the past few years, and what they have changed in approaches to quality management.
THE ROLE OF CLUSTERS IN THE REALIZATION OF BIOECONOMIC POTENTIAL
Authors: Vasylyuk Sofiya
Published: August 2021

It is substantiated that the development of bioeconomy, which skillfully combines the economy, bioresources, ecosystems and biotechnology, which help to create quality products and processes based on renewable raw materials. It is proved that based on innovative approaches, the bioeconomy contributes to job creation and development of regions, including those dominated by rural areas, which are powerful centers of biological resources. It is proved that the process of technology transformation can be accelerated by using the mechanisms of cluster concept implementation in the bioeconomy both at the regional and sectoral levels. It is determined that the creation of innovation clusters allows to obtain an innovative product through the formation of close relationships between firms, suppliers, customers and centers of science and knowledge (research centers, research institutes, universities) and has the necessary prerequisites to ensure high competitiveness. its rapid spread through a network of existing relationships in the general regional economic space by building technological chains: product creation - production - launch on the market. It is substantiated that fundamental practice-oriented science can play an important role in ensuring the appropriate level of trust in the formation of Ukrainian biotechnology clusters. Bioeconomy as a new attractive and efficient economic concept contributes to the development of innovative processes and products, reducing greenhouse gas emissions, and an effective tool for realizing its potential through coordinated identification of technological and market trends are clusters that provide appropriate communication platforms. Key biotechnology clusters for the bioeconomy are formed on the basis of raw materials, technical capabilities, logistics, domestic market and last but not least industrial traditions, and the main driver in their creation is a favorable starting position of a functioning industry combined with market demand for biologically based products.
Ukraine has the necessary prerequisites (bioresource potential, basic practice-oriented science, breakthrough research laboratories, development centers, industrial and technological organizations, etc.) for the formation of promising high-tech bioeconomic clusters, and the correct adaptation of known effective clustering strategies to its national structure. can allow our country to occupy leading positions in world bioeconomic rankings.
THE EVALUATION OF SMALL BUSINESS GROWTH IN THE REGIONS
Authors: Sydoruk Iryna
Published: August 2021

The article offers a methodical approach to determining the level of small business growth in the regions of Ukraine, based on the calculation of the integrated index.
Small business is an important component of region’s economy, but its role and importance in socio-economic development vary depending on the heterogeneous industrial development of the regions.
There is a need for a comprehensive assessment of the level of small business development to identify growth points and areas of support. In author’s opinion, the indicators of small business development currently used to determine the effectiveness of the implementation of regional programs to support small business do not reflect the impact of small business activities on the regional development at all.
The author focuses the reader’s attention on determination of the level of development of small business and its role in the economy of the regions using the method of integrated index. This index is taken into consideration the extensiveness, intensity and social significance of small business. The coefficient of extensiveness is the share of small enterprises in the total number of enterprises in the region; the intensity coefficient is the share of the volume of products (goods, services) sold by small enterprises in the total volume of products (goods, services) sold in the region. The social significance of small business is calculated as the geometric mean of the product of the share of employees in small enterprises in the total number of employees in enterprises of the region and the share of personnel costs of small enterprises in total personnel costs of all enterprises in the region.
The calculation of the general index of small business development in the regions is provided in the article. It allows to draw conclusions that small business has the greatest impact on the development of Kherson, Chernivtsi and Kirovohrad regions, and the least - on the development of Donetsk and Dnipropetrovsk regions. The article concludes by outlining prospects for further research. The analysis of indicators of extensiveness, intensity and social significance of small business makes it possible to highlight the problems that hinder its successful growth in the regions and require concentration of efforts for urgent solution.
ACCOUNTING AND ANALYTICAL TOOLS IN RESERVES AND PROVISIONS OF CAPITAL OF COMMERCIAL ENTERPRISE MANAGEMENT
Authors: Karyy Oleh , Lemishovska Olesia , Voskalo Natalia
Published: August 2021

The financial and economic content of the processes of reservation and creation of provisions for future expenses and payments at an enterprise is considered. There is argued the growing importance of creating their own reserve system by commercial enterprises in the context of systemic crises of global and national socio-economic environments, exacerbated by the negative impact of the global pandemic, the loss of commercial enterprises of part of the capital to measures to overcome it. The content, functional role and practical significance of accounting and analytical provision of management processes aimed at creating and using various components of reserve and insurance (trust) funds are revealed. A critical analysis of the regulatory framework for the reflection of information about these objects in the accounting and public reporting of an enterprise is carried out. It is emphasized that in both domestic and global practice, the procedures for reflection of the formation of capital reserves and a significant amount of provisions are purely payment in nature without the purposive delineation of stock assets. In this regard, it is recommended to support the formed reserves with funds on deposit accounts or by making long-term or current investments. At the same time, such an operation leads to the withdrawal of current assets, deferral of income and a compromise between risk and return. The information from the financial statements on the state of reservation of any Ukrainian enterprises allows us to conclude that the existing approach to accounting verification of these objects as economic categories weakens the efficiency and practical effectiveness of the whole subsystem of reserve system management. To provide management processes with more analytical information on the availability of sources and means of insurance of the involved capital, modern commercial enterprises have formulated proposals on the expediency of introducing a functional accounting and analytical system in their activities.
Identification of Employees' Preferences for Health and Wellness Programmes
Authors: Sánchez Ricardo , Flegl Martin , Depoo Lucie
Published: August 2021

Today's workplace has created new challenges and opportunities for managers, as employees from three generations (Millennials, Generation X and Baby boomers) with different personal characteristics now form the workforce. It is crucial for a company's management to understand employees' needs regarding benefits, since employees' satisfaction is vital to their motivation and productivity. In this study, we analysed responses from 272 employees to a survey about their preferences for Health & Wellness programmes, using the Analytical Hierarchy Process methodology. The results reveal significant differences between generations, as well as between genders. The most desired programmes for younger generations are educational packages, whereas Baby boomers tend to prefer cultural events. Despite these differences, there is consensus among all the generations about the high importance of dental care programmes.
Reprodutibilidade teste-reteste de uma bateria de avaliação motora para jogadores de bocha paralímpica
Authors: Oliveira José Igor , Oliveira Lúcia Inês , Arruda Sidcley , Oliveira Saulo Melo
Published: August 2021

Objetivo: a bocha paralímpica é uma modalidade baseada em controle motor, tomada de decisão e precisão. Muito embora haja aumento no número de participantes e no desempenho apresentado pelos atletas nos eventos mundiais, diferente de outros esportes paralímpicos, a modalidade ainda não dispõe de protocolos para avaliação motora específicos destinados aos praticantes.Nosso objetivo foi montar e avaliar a reprodutibilidade de uma bateria de testes para avaliação das capacidades motoras na bocha paralímpica.

Método: Os testes selecionados consideraram características pertinentes a prática da modalidade: a) teste de coordenação de mãos; b) teste de tempo de reação de mãos; c) teste de capacidade aeróbia; e d) teste de agilidade em formato “oito”, escolhidos pela praticidade. Dez jogadores participaram da aplicação da bateria, sendo avaliados com 7 dias de diferença. Foram determinados o viés (método de Bland-Altman), o coeficiente de correlação intraclasse (CCI) e o erro padrão de medida (EPM).

Resultados: A análise dos dados revelou excelentes características de estabilidade das medidas ([coordenação de mãos: viés = -3.700; CCI = 0.87; EPM = 5.53]; [tempo de reação de mãos: viés = -0.500; CCI = 0.99; EPM = 1.53]; [capacidade aeróbia: viés = 8.333; CCI = 0.98; EPM = 16.44]; [agilidade no formato “oito”: viés = 2.980; CCI = 0.93; EPM = 5.28]).

Conclusão: Recomendamos avaliações em outros atletas no sentido de criar padrões normativos baseados nas classes funcionais e no nível de desempenho dos praticantes.
Vol. 14 Núm. 2 Supl. 1 (2021): Conference on Technology in Physical Activity and Sport. TAPAS 2020. 24th-27th November 2020
Authors: Caraballo Israel
Published: August 2021

Monograph on the use of technology in Physical Activity and Sport, linked to the 1st International Congress of Technology in Physical Activity and Sport, held on November 24-27, 2020, in Seville, Spain. The 28 best research papers presented at the Congress have been selected, and a blind peer review has been carried out to guarantee their quality. All of them deal with technology in the field of sports management, health, education and high performance in sports.
SITUATED LEARNING AND PROFESSIONAL DEVELOPMENT: A CASE STUDY OF APPLYING COGNITIVE APPRENTICESHIP AND COMMUNITY OF PRACTICES IN A KINDERGARTEN
Authors: Cheng Ching-Ching
Published: August 2021

The purpose of this study is to implement and evaluate a teacher training program based on the framework of situated learning. Adapting from the situated learning approaches, the author implemented two in-service teacher training programs based on cognitive apprenticeship and community of practices respectively. Each training program was adopted in a different campus of a private kindergarten. During the six-month training, researcher conducted a qualitative research to evaluate the effectiveness of the training program. To investigate how teachers improved their professional skills in constructive instruction, the researcher invited four supervisors and 10 kindergarten teachers to participate in the training program. The qualitative data included classroom observation, focus group, interviews, and teachers’ reflection notes. The results suggest that both programs may aid learning of engaging in constructivist instruction by providing external supports such as model instruction plans, mentoring, cooperating to solve problems. Nevertheless, the relationship or power hierarchy between mentors and learners is important in cultivating mentees’ capabilities. Practices sharing in community of practices approach, rather than supervisors’ expertise and diagnosis, will help the mentees to enhance their capabilities of solving problems.
Key words: cognitive apprenticeship, community of practices, kindergarten teacher, professional development, situated learning, teacher training.
THE IMPACT OF THE ANIMALS ON CHILDREN'S LEARNING AND THEIR DEVELOPMENT - A STUDY OF WHAT CHILDREN LEARN FROM AND WITH PETS: THE EXAMPLE OF DOG AND CAT
Authors: Simeonsdotter Svensson Agneta
Published: August 2021

The purpose of this study is to produce knowledge about the impact of pets on preschool children's desire to learn and their development. The research question asked is: What do children learn from and with pets: The example of dog and cat? Socio-cultural theories and developmental pedagogy are used in order to study children’s learning in the preschool. The socio-cultural theories are based on a model describing interactions between people presented by Vygotskij (1978) and further developed by Säljö (2011). This study employed a qualitative exploratory research method with the aim of gaining knowledge concerning a group of 24 children, aged 4-5 years. Individual interviews were used as the method of data collection. The results are presented as two main categories: 1) The pet supports the child in their learning and development process 2) The child is the teacher of the pet. Each main category comprised two subcategories: 1a) Developing empathy and emotions, 1b) Being good at school-related tasks, 2a) Teaching the pet playful exercises, 2b) Teaching the pet to obey. The results show that pets provide children with positive experiences and a sense of feeling good. The children said that they could talk to all the animals and that the animals are listening. When a child is doing activities with an animal or tries to teach an animal some exercises, the child receives a response from the animal. This leads on to new experiences and an increased knowledge regarding social behavior. Using pets for educational purposes in the home, preschool and school, might stimulate an interest in animal care and a commitment to the world´s wildlife and fauna in general. Key words: animal, children, development, preschool learning.
Sigmoid Volvulus in a Neonate with Anorectal Malformation: A Case Report
Authors: MC Wilms , M Lienert
Published: August 2021

Background: Sigmoid volvulus in the neonate is an extremely rare condition needing emergency treatment. Sporadic cases of neonatal sigmoid volvulus and some in association with Hirschsprung’s disease have been documented. Sigmoid volvulus has been described only twice in the literature in association with anorectal malformation. However, newborns with anorectal malformations might be especially at risk for sigmoid volvulus due to increased intraluminal intestinal weight caused by bowel obstruction and its existence might be underreported. Case presentation: This is the case report of a full-term neonate with trisomy 21 who was diagnosed with anorectal malformation upon birth. An abdominal X-ray on his second day of life showed typical radiological findings of sigmoid volvulus as described by the radiologist. However, the findings were interpreted as a dilated rectosigmoid sling typical for anorectal malformation by the surgeon and a transverse loop colostomy was placed. On the fourth postoperative day sigmoid perforation occurred and led to meconium peritonitis and septic shock. An emergency laparotomy was performed and a perforation at the distal sigmoid colon was found. Conclusion: There is an urgent need to raise awareness as to the existence of sigmoid volvulus in the neonate with anorectal malformations. The distinct radiological findings of the “coffee bean sign”, the “northern exposure sign” and an empty rectum allow to distinguish the extremely rare sigmoid volvulus from the common finding of a dilated rectosigmoid in patients with anorectal malformations. Detorsion of sigmoid volvulus is vital to preventing sigmoid perforation.
EAEU INTEGRATION PROCESSES AS A FACTOR INFLUENCING THE TRANSFORMATION OF RUSSIAN BUSINESS LEGISLATION
Authors:   Institute of State and Law of the Russian Academy of Sciences, CHERKESOVA LARISA
Published: August 2021

The processes taking place in the modern world allow us to say that interstate integration is actively developing, and as a result, similar processes are observed in the sphere of law. In this regard, it is clear that there is a need to reflect and identify general trends in the transformation of Russian legislation under the influence of integration processes. This article attempts to identify the relationship between legal and economic integration, to determine the role and place of the EAEU integration processes in the ongoing changes in Russian business legislation, and to formulate proposals to improve the effectiveness of legal integration. First of all, it is necessary to understand the nature of the process, and the historical, legal and economic aspects of integration within the EAEU are monitored and analyzed. In addition, the results of a detailed analysis of both the regulatory component, in terms of the regulation of economic spheres, and the positions of a number of researchers of integration processes, which allowed to draw an unequivocal conclusion about the high degree of influence of the EAEU integration processes on the business legislation of the Russian Federation. Trends in the impact of the EAEU Court on legal integration and, as a result, on the transformation of Russian law have also been revealed. The opinion formulated proposals to improve the effectiveness of legal changes in the sphere of business law of Russia in connection with the integration processes of the EAEU, as well as the opinion on the need to consider the issue of giving the EAEU Court the power to resolve disputes of economic entities of the EAEU member states (international arbitration court). Attention is also drawn to the need for closer cooperation between national executive, legislative, judicial and law enforcement authorities.
REGULATORY SANDBOXES AND THEIR IMPACT ON THE BUSINESS LAW INDUSTRY OF THE RUSSIAN FEDERATION IN THE CONTEXT OF THEORETICAL AND PRACTICAL ASPECTS OF LEGAL EXPERIMENT
Authors:   Sochi Institute (branch) of the RUDN, BOROZDINA MARIA
Published: August 2021

This legal study is an attempt by the author to conduct a full analysis of the Federal Law «On experimental legal regimes in the field of digital innovation in the Russian Federation», which has not yet entered into force, as well as his satellite laws introducing into the legal system experimental legal regimes in the face of regulatory sandboxes, in order to determine their impact and significance on the development of the industry of domestic business law, and, in particular, on the legislation of the Russian Federation on entrepreneurship. As a conclusion, it is noted that the Federal Law "On Experimental Legal Regimes in the Field of Digital Innovations in the Russian Federation", as well as those acts that ensure the implementation of the objectives that it lays down (satellite laws and acts of state authorities, the creation of which is directly delegated by this federal law) are aimed not only at creating favorable conditions for the development of digital innovation in the Russian Federation, but also at developing the industry of domestic entrepreneurs. It is also noted that such development is also ensured by granting legal and regulatory powers, first of all, to the Government of the Russian Federation, as well as to a number of other federal executive bodies and executive bodies of the subjects of the Russian Federation, which in turn tells us about the increasing development of the concept of delegated lawmaking in our country, as well as localization and detailing of legal regulation in the spheres of economic activity depending on its specifics.
INTERNATIONAL PROTECTION OF THE SPHERE OF BLOCKCHAIN FUNCTIONING AGAINST CRIMINAL OFFENCES: LANDSCAPE, DYNAMICS AND PERSPECTIVES
Authors:   Volgograd State University, MKRTCHIAN SONA
Published: August 2021

The purpose of the research is to identify the most successful ideas and legal techniques used in international law regarding regulations of defense against criminal offences in the sphere of cybersecurity, as well as blockchain functioning and cryptocurrency turnover. Results. On the basis of the positive international experience in regulating the criminal legal protection of relations in the last-mentioned sphere, the following directions for improving Russian criminal legislation were formulated: 1) fixation of the fair limits of the criminal administrative liability for defendant in reliance on the level of public danger of his personality and his offences; 2) creation of the formally defined crimes against computer information; 3) criminalization of some actions that precede cybercrimes; 4) expansion in the number of the mentioning of the sign "by interfering in the functioning of the resources of the storing, processing or transmitting computer information or data telecommunications network" as an essential or aggravating elements of crimes, typically committed with the use of information technologies (for example, in the articles number 133, 134, 135, 137, 138, 139, 146, 147, 163, 165, 240, 240.1, 241 of the Criminal Code of the Russian Federation, etc.); 5) expansion in the number of the elements of crimes combined in the chapter 28 of the Criminal Code of the Russian Federation, in reliance on the modern criminal schemes and typical criminal situations in the world of information technology; 6) expansion of the effect of the article number 274.1 of the Criminal Code of the Russian Federation on any criminal offense to the critical information infrastructure of the Russian Federation and inclusion of the additional aggravating elements in the text of this article.
FEATURES AND ROLE OF STATE FINANCIAL CONTROL AS PART OF THE RUSSIAN LEGAL SYSTEM
Authors:   Financial University under the Government of the Russian Federation, SHEPELEVA DINA
Published: August 2021

In the modern Russian state, a large-scale reform of supervisory and control activities is being carried out. The priority task here is to improve the effectiveness and efficiency of control and supervision, as well as the revision and updating of legislation. In recent years, the reform of updating and improving legislation in the field of financial control has been carried out and continues to be carried out. Indeed, to date, a huge array of acts has accumulated, including those of the early 90s with a noticeably outdated system of bodies and an outdated concept of financial control. Therefore, they are recognized as invalid and new strategic documents of a national, informational, and economic nature, approved by Decrees of the President of our state and containing priority goals, take their place. Therefore the research trends and impact of control activities and effectiveness through the implementation of these activities is of particular relevance that derives, including the purpose of the article, which aims to explore issues of financial control and oversight, in both practical and theoretical aspects. It is important to analyze the role of financial control, its main directions at different stages of this control mechanism, the list of key features of state financial control, the sources on which control activities are based, the methods by which its subjects implement financial control and carry out control measures. And also to characterize it as part of public administration, the institution of financial law and the control relationship, since it is through the legal relationship with its inherent features that control is implemented. A your authorized subject is able to influence other participants of legal relations through mandatory regulations to oblige to a legitimate implementation of the law, and its specific object as the second party to legal relations which are not simply the specific benefit and a specific person (natural, legal), and public law, are obliged to observe the norms of financial law
LA GESTIÓN INTEGRAL DE LOS RESIDUOS SÓLIDOS URBANOS Y SU IMPACTO EN TERRITORIOS DE BORDE: el caso del conflicto de la escombrera de Km 9, Comodoro Rivadavia, Chubut Argentina
Authors: Poblete Emili , Guichapiren Melisa , Baeza Fabricio
Published: August 2021

El presente trabajo constituye un análisis preliminar del conflicto ambiental urbano en un territorio de borde de la ciudad de Comodoro Rivadavia, provincia del Chubut (Patagonia Argentina), a raíz de los cambios de usos de suelo en el periurbano y de la implementación de un nuevo modelo de gestión integral de los residuos urbanos – GIRSU- que está desarrollando el gobierno local, se advierte una serie de tensiones y conflictos en torno a las externalidades negativas que genera la presencia de una escombrera sobre los productores agropecuarios y vecinos del periurbano. En este sentido, este análisis tiene por objetivo abordar el conflicto ambiental urbano a partir de identificar los actores involucrados y los intereses en juego. Para ello se desarrolló un sendero metodológico que implica examinar documentos oficiales, recolección de fuentes secundarias y entrevistas a los actores sociales involucrados. Esto permitió evidenciar los efectos negativos de la implementación de políticas públicas, la ausencia de planificación urbana y de acciones coordinadas conforme a un espacio periurbano en continua mutación. El presente trabajo constituye un análisis preliminar del conflicto ambiental urbano en un territorio de borde de la ciudad de Comodoro Rivadavia, provincia del Chubut (Patagonia Argentina), a raíz de los cambios de usos de suelo en el periurbano y de la implementación de un nuevo modelo de gestión integral de los residuos urbanos – GIRSU- que está desarrollando el gobierno local, se advierte una serie de tensiones y conflictos en torno a las externalidades negativas que genera la presencia de una escombrera sobre los productores agropecuarios y vecinos del periurbano. En este sentido, este análisis tiene por objetivo abordar el conflicto ambiental urbano a partir de identificar los actores involucrados y los intereses en juego. Para ello se desarrolló un sendero metodológico que implica examinar documentos oficiales, recolección de fuentes secundarias y entrevistas a los actores sociales involucrados. Esto permitió evidenciar los efectos negativos de la implementación de políticas públicas, la ausencia de planificación urbana y de acciones coordinadas conforme a un espacio periurbano en continua mutación.
ESTUDO SOBRE AS POLÍTICAS DE HABITAÇÃO NA CIDADE DE CODÓ/MA, NO PERÍODO DE 1960 A 2019
Authors: Corrêa Albideias de Oliveira Corrêa , Lima Alex
Published: August 2021

Este trabalho objetivou analisar o histórico das políticas de habitação na cidade de Codó/MA, no período de 1960 a 2019. Para tanto, pautou-se em pesquisa documental, por meio da Lei de Acesso à Informação (LAI), coletas de dados junto às instituições bancárias diretamente ligadas à questão e consultas junto à Prefeitura Municipal de Codó/MA. Além disso, a pesquisa de campo foi realizada junto aos moradores dos conjuntos habitacionais, para fins de aferição e captação de informações. Os dados da pesquisa indicaram ter havido sete programas de habitação desenvolvidos em Codó desde a segunda metade do século XX, sendo que o século XXI representou 92,34% das habitações implementadas, destacando-se o Programa Minha Casa Minha Vida (PMCMV), que também não se caracterizou apenas por ser uma política eminentemente habitacional, mas por ser, sobretudo, um serviço voltado aos interesses dos setores privados de construção civil.
A COMPANHIA DE DESENVOLVIMENTO HABITACIONAL E URBANO DO ESTADO DE SÃO PAULO E O PROGRAMA MINHA CASA MINHA VIDA NAS PEQUENAS CIDADES DE PROMISSÃO/SP E PENÁPOLIS/SP
Authors: Pavoni João
Published: August 2021

As políticas habitacionais desenvolvidas pelo Estado brasileiro são fortes vetores de produção do espaço urbano, contribuindo para o acesso à moradia e ao mesmo tempo para o aumento das diferenças socioespaciais. No presente artigo, objetiva-se analisar a implantação das políticas habitacionais da Companhia de Desenvolvimento Habitacional e Urbano (Estado de São Paulo) e do Programa “Minha Casa, Minha Vida” nas pequenas cidades de Promissão/SP e Penápolis/SP. Para a realização da pesquisa, foram realizados trabalhos de campo, entrevistas com os gestores locais, coleta de dados relativos à produção habitacional, leitura do referencial teórico específico e mapeamento dos empreendimentos por meio de softwares de geoprocessamento. Como resultados, pôde-se verificar os eixos de expansão urbana das cidades analisadas, considerando as localizações periféricas dos empreendimentos habitacionais construídos, que contribuem para o aumento das distâncias aos equipamentos e serviços urbanos e para processos de diferenciação socioespacial.
PERSPECTIVAS SOBRE A CIDADE PEQUENA E SUAS DINÂMICAS ESPACIAIS: um estudo de São Felipe - BA
Authors: Leandro Maiara , Ferraz Ana Emília
Published: August 2021

O presente estudo tem como objetivo discutir a produção do espaço da cidade pequena face a contextualização da dinâmica reprodutiva de São Felipe e sua inserção na rede urbana do Recôncavo Baiano. Este trabalho é produto de debates, pesquisa empírica e reflexões teóricas apresentados em parte num capítulo da dissertação de mestrado da autora, que tratou, entre outras questões, da produção do espaço na cidade pequena em meio as formas de representações socioespaciais e apropriação das práticas cotidianas. O percurso metodológico é composto de revisão bibliográfica; instrumentos de coleta de dados, com o uso de entrevista semiestruturada e questionários; mapeamento, organização e sistematização das informações; e, análise dos resultados. Com o estudo de caso foi possível apreender aspectos contraditórios e particulares da produção do espaço em São Felipe, ao inferir-se acerca da realidade de uma cidade pequena influenciada pelas relações de interdependência com o espaço rural e complexidade das relações entre forma-conteúdo com particularidades que lhes são próprias, sem desconsiderar a influência com outras cidades como parte do processo de urbanização capitalista em meio as novas relações espaço-tempo e mudanças na dinâmica urbana contemporânea.
CIDADES DE PEQUENO PORTE: uma aproximação conceitual e comparativa da região metropolitana de Londrina/PR a partir das regiões de influência das cidades (REGIC)
Authors: Santana Thiago , Silva Matheus , Oliveira Edilson
Published: August 2021

Os debates acerca das cidades de pequeno porte têm se tornado mais presentes nos últimos anos com um maior número de publicações por parte dos especialistas da área que incentivam terceiros a notarem a relevâncias dessas no cenário geográfico brasileiro. Por mais que se produza muito sobre o tema em voga, existem muitas discussões a serem exploradas. Nesse sentido, o presente trabalho tem como objetivo abordar a discussão conceitual para se diferenciar as cidades pequenas das cidades locais com o auxílio da pesquisa do Instituto Brasileiro de Geografia e Estatística (IBGE) que consiste nas Regiões de Influência das Cidades (REGIC) e a partir disso, compreender o índice de atração da Região de Metropolitana de Londrina a partir das variáveis “compras” e “saúde”. Dessa forma, foi possível compreender que para que se considere uma cidade que tenha padrões de cidade pequena, é levado em consideração que ela possua não somente índice de atração relevante em uma só temática, mas sim, em ambas elas, tanto da área da saúde, quanto área relacionada a compras.
Transient Receptor Potential (TRP) Ion Channels Involved in Malignant Glioma Cell Death and Therapeutic Perspectives
Authors: Lefranc Florence
Published: August 2021

Among the most biologically, thus clinically, aggressive primary brain tumors are found malignant gliomas. Despite recent advances in adjuvant therapies, which include targeted and immunotherapies, after surgery and radio/chemotherapy, the tumor is recurrent and always lethal. Malignant gliomas also contain a pool of initiating stem cells that are highly invasive and resistant to conventional treatment. Ion channels and transporters are markedly involved in cancer cell biology, including glioma cell biology. Transient receptor potential (TRP) ion channels are calcium-permeable channels implicated in Ca2+ changes in multiple cellular compartments by modulating the driving force for Ca2+ entry. Recent scientific reports have shown that these channels contribute to the increase in glioblastoma aggressiveness, with glioblastoma representing the ultimate level of glioma malignancy. The current review focuses on each type of TRP ion channel potentially involved in malignant glioma cell death, with the ultimate goal of identifying new therapeutic targets to clinically combat malignant gliomas. It thus appears that cannabidiol targeting the TRPV2 type could be such a potential target.
Microfluidics-Based Single-Cell Research for Intercellular Interaction
Authors: Pang Long , Ding Jing , Liu Xi-Xian , Kou Zhixuan , Guo Lulu , Xu Xi , Fan Shih-Kang
Published: August 2021

Intercellular interaction between cell–cell and cell–ECM is critical to numerous biology and medical studies, such as stem cell differentiation, immunotherapy and tissue engineering. Traditional methods employed for delving into intercellular interaction are limited by expensive equipment and sophisticated procedures. Microfluidics technique is considered as one of the powerful measures capable of precisely capturing and manipulating cells and achieving low reagent consumption and high throughput with decidedly integrated functional components. Over the past few years, microfluidics-based systems for intercellular interaction study at a single-cell level have become frequently adopted. This review focuses on microfluidic single-cell studies for intercellular interaction in a 2D or 3D environment with a variety of cell manipulating techniques and applications. The challenges to be overcome are highlighted.
Profilin Isoforms in Health and Disease – All the Same but Different
Authors: Murk Kai , Ornaghi Marta , Schiweck Juliane
Published: August 2021

Profilins are small actin binding proteins, which are structurally conserved throughout evolution. They are probably best known to promote and direct actin polymerization. However, they also participate in numerous cell biological processes beyond the roles typically ascribed to the actin cytoskeleton. Moreover, most complex organisms express several profilin isoforms. Their cellular functions are far from being understood, whereas a growing number of publications indicate that profilin isoforms are involved in the pathogenesis of various diseases. In this review, we will provide an overview of the profilin family and “typical” profilin properties including the control of actin dynamics. We will then discuss the profilin isoforms of higher animals in detail. In terms of cellular functions, we will focus on the role of Profilin 1 (PFN1) and Profilin 2a (PFN2a), which are co-expressed in the central nervous system. Finally, we will discuss recent findings that link PFN1 and PFN2a to neurological diseases, such as amyotrophic lateral sclerosis (ALS), Fragile X syndrome (FXS), Huntington’s disease and spinal muscular atrophy (SMA).