bluuebunny/crossref_metadata_2025 huggingface dataset:
Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study
Authors: Komolmit Piyawat , Kimtrakool Sayamon , Suksawatamnuay Sirinporn , Thanapirom Kessarin , Chattrasophon Kanita , Thaimai Panarat , Chirathaworn Chintana , Poovorawan Yong
Published: August 2017

Hepatic fibrosis is the net accumulation of matrix tissue components which controlled by pro-fibrolytic enzymes, matrix metalloproteinases (MMPs), and pro-fibrotic cytokine, TGF-β1, and enzymes, tissue inhibitors of MMPs (TIMPs). Vitamin D (VD) supplementation has been shown to reverse these processes in vitro and in vivo. This study sought to determine the effect of VD supplementation on serum fibrotic markers in chronic hepatitis C (CHC) patients. Fifty-four CHC patients with VD deficiency were randomized into two groups, a VD group (n = 29) and a placebo group (n = 29). The serum levels of 25-hydroxy VD, TGF-β1, TIMP-1, MMP2 and MMP9 were measured at baseline and at the end of the 6-week study period. Upon correction of VD levels, TGF-β1 and TIMP-1 levels were decreased, and the MMP2 and MMP9 levels were significantly increased in the VD group. A comparison of the mean changes (delta) in the markers between groups showed that TGF-β1 and TIMP-1 levels were significantly decreased and the MMP2 and MMP9 were significantly higher in the VD group than in the placebo group. By using CHC patients as a model, this study provides additional evidence that VD plays an important role in the reversal of hepatic fibrogenesis.
Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo
Authors: Liu Haipeng , Su Danmei , Zhang Jinlong , Ge Shuaishuai , Li Youwei , Wang Fei , Gravel Michel , Roulston Anne , Song Qin , Xu Wei , Liang Joshua G. , Shore Gordon , Wang Xiaodong , Liang Peng
Published: August 2017

TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) has long been considered a tantalizing target for cancer therapy because it mediates activation of the extrinsic apoptosis pathway in a tumor-specific manner by binding to and trimerizing its functional receptors DR4 or DR5. Despite initial promise, both recombinant human TRAIL (native TRAIL) and dimeric DR4/DR5 agonist monoclonal antibodies (mAbs) failed in multiple human clinical trials. Here we show that in-frame fusion of human C-propeptide of α1(I) collagen (Trimer-Tag) to the C-terminus of mature human TRAIL leads to a disulfide bond-linked homotrimer which can be expressed at high levels as a secreted protein from CHO cells. The resulting TRAIL-Trimer not only retains similar bioactivity and receptor binding kinetics as native TRAIL in vitro which are 4–5 orders of magnitude superior to that of dimeric TRAIL-Fc, but also manifests more favorable pharmacokinetic and antitumor pharmacodynamic profiles in vivo than that of native TRAIL. Taken together, this work provides direct evidence for the in vivo antitumor efficacy of TRAIL being proportional to systemic drug exposure and suggests that the previous clinical failures may have been due to rapid systemic clearance of native TRAIL and poor apoptosis-inducing potency of dimeric agonist mAbs despite their long serum half-lives.
The Combination of RNA and Protein Profiling Reveals the Response to Nitrogen Depletion in Thalassiosira pseudonana
Authors: Jian Jianbo , Zeng Dezhi , Wei Wei , Lin Hongmin , Li Ping , Liu Wenhua
Published: August 2017

Nitrogen (N) is essential for the growth of algae, and its concentration varies greatly in the ocean, which has been regarded as a limitation for phytoplankton growth. Despite its great importance, most of the existing studies on the mechanisms underlying the effects of N on diatoms have focused on physiology, biochemistry and a few target genes and have rarely involved whole genomic analyses. Therefore, in this study, we integrated physiological data with RNA and protein profiling data to reveal the response strategy of Thalassiosira pseudonana under N-depleted conditions. Physiological measurements indicated that the cell growth capacity and chlorophyll content of the cells decreased, as did the expression of photosynthesis- and chlorophyll biosynthesis-related genes or proteins. The RNA-Seq profile results showed that T. pseudonana responded to N deprivation through increases in glycolysis, the TCA cycle and N metabolism as well as down-regulation in the Calvin cycle, gluconeogenesis, pentose phosphate, oxidative phosphorylation and lipid synthesis. These results provide a basic understanding for further research addressing how N affects phytoplankton in terms of genomics.
Temporal trends in Prevalence, Awareness, Treatment, and Control of Hypertension from 2000 to 2010 in Chengdu, China
Authors: Huang Gang , Xu Jun-bo , Liu Ya , Liu Zhao-hui , Zhang Yun-lan , Wu Yue-Lei , Wen Rui-lian , Zhu Shi , Zhang Ting-jie
Published: August 2017

This study aimed to describe trends in prevalence, awareness, treatment, and control in hypertension in Chengdu from 2000 to 2010. Two community-based cross sectional surveys were conducted among those aged 40–79 years in 2000 (n = 4850) and 2010 (n = 5456). Demographic characteristics, blood pressure (BP) and associated risk factors were examined. Mean systolic and diastolic BP increased from 117.8 ± 33.9 to 132.1 ± 21.2 mmHg (P < 0.001), and 75.3 ± 19.1 to 79.3 ± 11.2 mmHg (P < 0.001) over past decade, respectively. The prevalence of hypertension increased from 27.7 to 29.4% (P < 0.001). Awareness increased from 37.7 to 42.5% (P < 0.001). The overall treatment rate increased from 20.9 to 28.0% (P < 0.0001), while among subjects aware of hypertension, treatment increased from 46.9 to 65.8% (P < 0.001). In hypertensives, control increased from 6.8 to 6.9% (P = 0.6684). Nevertheless, in hypertensives aware and treated, control decreased from 32.5 to 24.3% (P = 0.020). Hypertension prevalence increased in the last decade, while awareness, treatment and control remained considerably low in Chengdu.
Indistinguishable odour enantiomers: Differences between peripheral and central-nervous electrophysiological responses
Authors: Poletti Sophia C. , Cavazzana Annachiara , Guducu Cagdas , Larsson Maria , Hummel Thomas
Published: August 2017

The ability of humans to discriminate enantiomeric odour pairs is substance –specific. Current literature suggests that psychophysical discrimination of odour enantiomers mainly depends on the peripheral processing at the level of the olfactory sensory neurons (OSN). To study the influence of central processing in discrimination, we investigated differences in the electrophysiological responses to psychophysically indistinguishable (+)- and (−)- rose oxide enantiomers at peripheral and central-nervous levels in humans. We recorded the electro-olfactogram (EOG) from the olfactory epithelium and the EEG-derived olfactory event-related potentials (OERP). Results from a psychophysical three alternative forced choice test indicated indistinguishability of the two odour enantiomers. In a total of 19 young participants EOG could be recorded in 74 and OERP in 95% of subjects. Significantly different EOG amplitudes and latencies were recorded in response to the 2 stimuli. However, no such differences in amplitude or latency emerged for the OERP. In conclusion, although the pair of enantiomer could be discriminated at a peripheral level this did not lead to a central-nervous/cognitive differentiation of the two stimuli.
The risk factors of bone metastases in patients with lung cancer
Authors: Zhou Yang , Yu Qing-Fu , Peng Ai-Fen , Tong Wei-Lai , Liu Jia-Ming , Liu Zhi-Li
Published: August 2017

The risk factors of bone metastasis in patients with lung cancer are still unclear. Here, a retrospective study including a series of consecutive patients who were diagnosed with lung cancer between January 2005 and November 2016 was carried out. A total of 2021 patients with lung cancer were included in this study and 23.9% of them were found to be bone metastases. For patients with bone metastases, adenocarcinoma (62.1%) was the most common pathological subtype, and rib (62.3%) was the most frequent distant metastatic site, followed by thoracic (53.8%) and lumbar spine (40.4%). The histopathologic type, CA-125 level and the concentration of alkaline phosphatase (ALP) were identified as the independent risk factors for bone metastases in lung cancer (P = 0.002, P = 0.001 and P < 0.001). The sensitivities and specificities of diagnosing bone metastasis by CA-125 were 32.1% and 80.8%, and by ALP were 41.3% and 77.1%, respectively. Thus, the incidence of bone metastases in lung cancer patients was relative high, and physicians should pay attention to the histopathologic type, the serum CA-125 and ALP concentrations when patients were firstly diagnosed with lung cancer for early detecting bone metastases.
Atomization characteristics and instabilities in the combustion of multi-component fuel droplets with high volatility differential
Authors: Rao D. Chaitanya Kumar , Karmakar Srinibas , Basu Saptarshi
Published: August 2017

We delineate and examine the successive stages of ligament-mediated atomization of burning multi-component fuel droplets. Time-resolved high-speed imaging experiments are performed with fuel blends (butanol/Jet A-1 and ethanol/Jet A-1) comprising wide volatility differential, which undergo distinct modes of secondary atomization. Upon the breakup of vapor bubble, depending on the aspect ratio, ligaments grow and break into well-defined (size) droplets for each mode of atomization. The breakup modes either induce mild/intense oscillations on the droplet or completely disintegrate the droplet (micro-explosion). For the blends with a relatively low volatility difference between the components, only bubble expansion contributes to the micro-explosion. In contrast, for blends with high volatility differential, both bubble growth as well as the instability at the interface contribute towards droplet breakup. The wrinkling pattern at the vapor-liquid interface suggests that a Rayleigh-Taylor type of instability triggered at the interface further expedites the droplet breakup.
RNA-seq analysis of amygdala tissue reveals characteristic expression profiles in schizophrenia
Authors: Chang X , Liu Y , Hahn C-G , Gur R E , Sleiman P M A , Hakonarson H
Published: August 2017

The amygdala brain region has been implicated in the pathophysiology of schizophrenia through emotion processing. However, transcriptome messages in the amygdala of schizophrenia patients have not been well studied. We used RNA sequencing to investigate gene-expression profiling in the amygdala tissues, and identified 569 upregulated and 192 downregulated genes from 22 schizophrenia patients and 24 non-psychiatric controls. Gene functional enrichment analysis demonstrated that the downregulated genes were enriched in pathways such as 'synaptic transmission' and 'behavior', whereas the upregulated genes were significantly over-represented in gene ontology pathways such as 'immune response' and 'blood vessel development'. Co-expression-based gene network analysis identified seven modules including four modules significantly associated with 'synaptic transmission', 'blood vessel development' or 'immune responses'. Taken together, our study provides novel insights into the molecular mechanism of schizophrenia, suggesting that precision-tailored therapeutic approaches aimed at normalizing the expression/function of specific gene networks could be a promising option in schizophrenia.
Erratum: Brain connectivity changes occurring following cognitive behavioural therapy for psychosis predict long-term recovery
Authors: Mason L , Peters E , Williams S C , Kumari V
Published: August 2017

Correction to: Translational Psychiatry (2017) 7, e1001; doi:10.1038/tp.2016.263; published online 17 January 2017 Throughout the text, the tests were incorrectly described as being one-tailed. The text should have stated that all tests were two-tailed.
A pneumatically assisted nanospray desorption electrospray ionization source for increased solvent versatility and enhanced metabolite detection from tissue
Authors: Duncan Kyle D. , Bergman Hilde-Marléne , Lanekoff Ingela
Published: August 2017

Pneumatically assisted nano-DESI offers improved sensitivity for metabolite species by 1–3 orders of magnitude through more complete desolvation and reduced ionization suppression.
Effectively enhancing the enantioseparation ability of β-cyclodextrin derivatives by de novo design and molecular modeling
Authors: Li Linwei , Wu Chengjun , Ma Yang , Zhou Shuhao , Li Zhen , Sun Tiemin
Published: August 2017

A novel strategy to improve the enantioseparation ability of β-cyclodextrin derivatives.
Estimation of relative oxygen metabolic activity microdistribution in biofilms based on the catastrophe point phenomenon during oxygen-infusion processes
Authors: Wang Jian-Hui , Li Hai-Yan , Guo Jin-Song , Yan Peng , Shen Yu , Chen You-Peng
Published: August 2017

A new method has been developed for estimating relative oxygen metabolic activity microdistribution in biofilms based on catastrophe points during oxygen-infusion processes.
Recent advances in biomaterials for the treatment of diabetic foot ulcers
Authors: Kasiewicz Lisa N. , Whitehead Kathryn A.
Published: August 2017

Diabetes mellitus is one of the most challenging epidemics facing the world today, with over 300 million patients affected worldwide.
Gd3+-Functionalized gold nanoclusters for fluorescence–magnetic resonance bimodal imaging
Authors: Liang Guohai , Xiao Lifu
Published: August 2017

Gd3+-Functionalized gold nanoclusters with high relaxivity and excellent biocompatibility are synthesized for optical and MR imaging.
Unusual reactivity of rhodium carbenes with allenes: an efficient asymmetric synthesis of methylenetetrahydropyran scaffolds
Authors: Torres Òscar , Solà Miquel , Roglans Anna , Pla-Quintana Anna
Published: August 2017

The reaction of a rhodium vinyl carbene with an O-tethered allene stereoselectively produces the 4-methylenetetrahydropyran core through a rhodium trimethylenemethane-like intermediate.
First principles study of oxygen molecule interaction with the graphitic active sites of a boron-doped pyrolyzed Fe–N–C catalyst
Authors: Fajrial Apresio K. , Saputro Adhitya G. , Agusta Mohammad K. , Rusydi Febdian , Nugraha Nugraha , Dipojono Hermawan K.
Published: August 2017

A boron-doped pyrolyzed Fe–N–C catalyst possesses high stability and the ability to facilitate O2 dissociation through O2 side-on adsorption.
Endohedral gas adsorption by cucurbit[7]uril: a theoretical study
Authors: Pan Sudip , Jana Gourhari , Gupta Ashutosh , Merino Gabriel , Chattaraj Pratim K.
Published: August 2017

Cucurbit[7]uril adsorbs SO2 selectively over other gas molecules such as C2H2, C2H4, C2H6, CH4, F2, Cl2, NO2, NO, CO2, CO, H2S, N2, and H2, because of the combined effects of electrostatic and dispersion interactions.
Piezoelectricity enhancement and bandstructure modification of atomic defect-mediated MoS2 monolayer
Authors: Yu Sheng , Rice Quinton , Neupane Tikaram , Tabibi Bagher , Li Qiliang , Seo Felix Jaetae
Published: August 2017

Piezoelectricity appears in the inversion asymmetric crystal that converts mechanical deformation to electricity.
Long-range surface plasmon resonance and surface-enhanced Raman scattering on X-shaped gold plasmonic nanohole arrays
Authors: Hou Chao , Galvan Daniel David , Meng Guowen , Yu Qiuming
Published: August 2017

X-shaped gold plasmonic nanohole arrays embedded in refractive index-matched dielectric media are designed and optimized as a long-range SERS substrate.
Investigation into the energy storage behaviour of layered α-V2O5 as a pseudo-capacitive electrode using operando Raman spectroscopy and a quartz crystal microbalance
Authors: Yao Minghai , Wu Peng , Cheng Shuang , Yang Lufeng , Zhu Yuanyuan , Wang Mengkun , Luo Haowei , Wang Bangfen , Ye Daiqi , Liu Meilin
Published: August 2017

α-V2O5 nanowires with a layered structure have been fabricated through a two-step procedure.
Magneto-structural correlations in dirhenium(iv) complexes possessing magnetic pathways with even or odd numbers of atoms
Authors: Pedersen Anders H. , Julve Miguel , Martínez-Lillo José , Cano Joan , Brechin Euan K.
Published: August 2017

Spin-polarization enforces either ferro- or antiferromagnetic exchange interactions between ReIV ions with odd or even numbers of intervening atoms.
Confined methanol within InOF-1: CO2 capture enhancement
Authors: Sánchez-González Elí , Mileo Paulo G. M. , Álvarez J. Raziel , González-Zamora Eduardo , Maurin Guillaume , Ibarra Ilich A.
Published: August 2017

The CO2 capture in InOF-1 was enhanced by confining small amounts of MeOH. DFT calculations coupled with forcefield based-MC simulations revealed that such an enhancement is due to an increase of the degree of confinement.
Multimodal imaging and photothermal therapy were simultaneously achieved in the core–shell UCNR structure by using single near-infrared light
Authors: Wang Chen , Xu Liangge , Xu Jiating , Yang Dan , Liu Bin , Gai Shili , He Fei , Yang Piaoping
Published: August 2017

Core–shell nanostructures consisting of plasmonic materials and lanthanide-doped upconversion nanoparticles (UCNPs) show promising applications in theranostics including bio-imaging, diagnosis and therapy.
Crown ether complexes of actinyls: a computational assessment of AnO2(15-crown-5)2+(An = U, Np, Pu, Am, Cm)
Authors: Hu Shu-Xian , Li Wan-Lu , Dong Liang , Gibson John K. , Li Jun
Published: August 2017

Computational characterization of AnO22+–(15-crown-5) complexes (An = U, Np, Pu, Am, and Cm) reveals actinyl insertion coordination to crown ether.
Stable high efficiency two-dimensional perovskite solar cells via cesium doping
Authors: Zhang Xu , Ren Xiaodong , Liu Bin , Munir Rahim , Zhu Xuejie , Yang Dong , Li Jianbo , Liu Yucheng , Smilgies Detlef-M. , Li Ruipeng , Yang Zhou , Niu Tianqi , Wang Xiuli , Amassian Aram , Zhao Kui , Liu Shengzhong (Frank)
Published: August 2017

Cs+doping into 2D (BA)2(MA)3Pb4I13perovskites boosts power conversion efficiency (PCE) to 13.7% and yields superior humidity and thermal stability.
Understanding the pH-dependent adsorption of ionizable compounds on graphene oxide using molecular dynamics simulations
Authors: Tang Huan , Zhao Ying , Yang Xiaonan , Liu Dongmei , Shan Sujie , Cui Fuyi , Xing Baoshan
Published: August 2017

Mechanism of the pH-dependent adsorption efficiency.
Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo
Authors: Shen Rong , Liu Disheng , Hou Chenchen , Liu Di , Zhao Lixia , Cheng Ju , Wang Degui , Bai Decheng
Published: August 2017

The aim of this research was to investigate the antioxidant and anti-apoptotic activities of Potentilla anserina polysaccharide (PAP) on kidney damage induced by cadmium (Cd) in vitro and in vivo.
Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets
Authors: Miles Fayth L. , Navarro Sandi L. , Schwarz Yvonne , Gu Haiwei , Djukovic Danijel , Randolph Timothy W. , Shojaie Ali , Kratz Mario , Hullar Meredith A. J. , Lampe Paul D. , Neuhouser Marian L. , Raftery Daniel , Lampe Johanna W.
Published: August 2017

Enterolignans, gut bacterial metabolites of plant lignans, affect biologic pathways relevant to chronic disease.
Native extracellular matrix-derived semipermeable, optically transparent, and inexpensive membrane inserts for microfluidic cell culture
Authors: Mondrinos Mark J. , Yi Yoon-Suk , Wu Nan-Kun , Ding Xueting , Huh Dongeun
Published: August 2017

This paper presents a new type of cell culture membranes engineered from native extracellular matrix (ECM) materials that are thin, semipermeable, optically transparent, and amenable to integration into microfluidic cell culture devices.
2D reentrant auxetic structures of graphene/CNT networks for omnidirectionally stretchable supercapacitors
Authors: Kim Byoung Soo , Lee Kangsuk , Kang Seulki , Lee Soyeon , Pyo Jun Beom , Choi In Suk , Char Kookheon , Park Jong Hyuk , Lee Sang-Soo , Lee Jonghwi , Son Jeong Gon
Published: August 2017

Stretchable energy storage systems are essential for the realization of implantable and epidermal electronics.
Rapid synthesis of lipid nanoparticles containing hydrophobic inorganic nanoparticles
Authors: Kulkarni Jayesh A. , Tam Yuen Yi C. , Chen Sam , Tam Ying K. , Zaifman Josh , Cullis Pieter R. , Biswas Souvik
Published: August 2017

We describe a facile and highly efficient rapid-mixing technique to entrap hydrophobic inorganic nanoparticles within lipid nanoparticles.
A general route to coat poly(cyclotriphosphazene-co-4,4′-sulfonyldiphenol) on various substrates and the derived N, P, S-doped hollow carbon shells for catalysis
Authors: Yang Shuliang , Zhu Yanan , Cao Changyan , Peng Li , Li Shumu , Zhai Dewei , Song Weiguo
Published: August 2017

A polymer containing N, P and S could be coated on various substrates, and the derived N, P, S-doped hollow carbon shells display good performance for selective oxidation of carbon–hydrogen bonds.
Correction: Broadband ultrafast photovoltaic detectors based on large-scale topological insulator Sb2Te3/STO heterostructures
Authors: Sun Honghui , Jiang Tian , Zang Yunyi , Zheng Xin , Gong Yan , Yan Yong , Xu Zhongjie , Liu Yu , Fang Liang , Cheng Xiang'ai , He Ke
Published: August 2017

Correction for ‘Broadband ultrafast photovoltaic detectors based on large-scale topological insulator Sb2Te3/STO heterostructures’ by Honghui Sun, et al., Nanoscale, 2017, 9, 9325–9332.
Control of the electrochemical and photophysical properties of N-substituted benzo[ghi]perylene derivatives
Authors: Tokuo Kokichi , Sakai Hayato , Sakanoue Tomo , Takenobu Taishi , Araki Yasuyuki , Wada Takehiko , Hasobe Taku
Published: August 2017

Orientation of the lone-pair of electron-dependent electrochemical and photophysical properties were successfully observed by using a series ofN-substituted benzo[ghi]perylene derivatives.
Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A
Authors: Zhang Hao , Ma Shiqiang , Xing Zhimin , Liu Lin , Fang Bowen , Xie Xingang , She Xuegong
Published: August 2017

A tandem radical cyclization towards the 6/6/5 tricyclic skeleton, which exists in numerous natural products, was developed in modest to good yields.
Pd/Ni catalyzed selective N–H/C–H methylation of amides by using peroxides as the methylating reagents via a radical process
Authors: Li Ze-lin , Cai Chun
Published: August 2017

A palladium/nickel catalyzed selective N–H/C–H methylation of amides by using peroxides is described, providing N-methylation products and C-methylation products in moderate to good yields.
A conductive carbon interlayer modified by magnetron sputtering for improved-performance lithium–sulfur batteries
Authors: Zhang Jing , Li Heqin , Lin Zhiwei , Tang Qiong , Qi Weiyu , Wang Lulu , Zheng Hao , Zhou Kuan
Published: August 2017

A carbon film was prepared by filter paper and modified by radio-frequency magnetron sputtering as a conductive interlayer for lithium–sulfur batteries.
Comparative studies on the interaction of nitrofuran antibiotics with bovine serum albumin
Authors: Zhang Qiulan , Ni Yongnian
Published: August 2017

The study indicated that the nitrofurazone (NFZ) offered stronger toxicity than nitrofurantoin (NFT) in the interactions with albumin.
Estimating contaminant source in chemical industry park using UAV-based monitoring platform, artificial neural network and atmospheric dispersion simulation
Authors: Qiu Sihang , Chen Bin , Wang Rongxiao , Zhu Zhengqiu , Wang Yuan , Qiu Xiaogang
Published: August 2017

The ANN-based source estimation approach can effectively locate and quantify the emission source using data from a UAV.
Synthesis and insecticidal assessment of some innovative heterocycles incorporating a thiadiazole moiety against the cotton leafworm, Spodoptera littoralis
Authors: Fadda Ahmed A. , El Salam M. Abd , Tawfik Eman H. , Anwar E. M. , Etman H. A.
Published: August 2017

A new 2-cyano-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide was utilized as a versatile precursor for the synthesis of various heterocycles.
Li states on a C–H vacancy in graphane: a first-principles study
Authors: Mapasha R. E. , Molepo M. P. , Chetty N.
Published: August 2017

The Li ion enhances the VCHinduced magnetism. The −1 charge doping shifts the Fermi level to the CBM further increasing magnetism. The +1 charge doping shifts the Fermi level to the VBM reducing magnetism.
Synthesis and properties of an intrinsic flame retardant silicone rubber containing phosphaphenanthrene structure
Authors: Chen Wei , Liu Yuansen , Xu Changan , Liu Yuan , Wang Qi
Published: August 2017

An intrinsic flame retardant silicone rubber was successfully prepared which possessed excellent self-extinguishing properties, high transparency and better mechanical properties.
One-step preparation of TiO2particles with controllable phase and morphology by plasma electrolysis
Authors: Liu Chenxu , Zhao Qian , Wang Linxiu , Zhang Jin , Tian Yu , Meng Yonggang
Published: August 2017

TiO2particles with controllable phase and morphology were prepared by one-step plasma electrolysis at room temperature.
Molecular design of organic small molecules based on diindole–diimide with fused aromatic heterocycles as donors for organic solar cells
Authors: Jin Ruifa , Irfan Ahmad
Published: August 2017

A series of novel diindole–diimide based molecules with different aromatic end groups have been designed as charge transport and donor materials for organic solar cells (OSCs).
Pd-catalyzed asymmetric allylic alkylations via C–H activation of N-allyl imines with glycinates
Authors: Trost Barry M. , Li Xiaoxun
Published: August 2017

Facile access to versatile α,β-diamine esters derives from an unprecedented C–H activation to generate aza-π-allyl palladium intermediates asymmetrically.
Simple contact mechanics model of the vertebrate cartilage
Authors: Persson B. N. J. , Kovalev A. , Gorb S. N.
Published: August 2017

We study a simple contact mechanics model for the vertebrate cartilage, which includes (bulk) osmotic effects.
Time lapse AFM on vesicle formation from mixed lipid bilayers induced by the membrane–active peptide melittin
Authors: Bodescu M. A. , Rosenkötter F. , Fritz J.
Published: August 2017

AFM shows that melittin causes nm-sized vesicle formation in the liquid phase close to lipid domain interfaces.
Metal-based magnetic fluids with core–shell structure FeB@SiO2 amorphous particles
Authors: Yu Mengchun , Bian Xiufang , Wang Tianqi , Wang Junzhang
Published: August 2017

Metal-based magnetic fluids with desirable high temperature performance based on core–shell FeB@SiO2 amorphous particles with high saturation magnetization.
Enhancing the thermoelectric performance of Cu3SnS4-based solid solutions through coordination of the Seebeck coefficient and carrier concentration
Authors: Yang Yuanbo , Ying Pengzhan , Wang Jinzhi , Liu Xianglian , Du Zhengliang , Chao Yimin , Cui Jiaolin
Published: August 2017

Through coordination of the Seebeck coefficient and carrier concentration in Cu3SnS4, TE performance improves significantly with theZTvalue of 0.75 at 790 K.
Reversible 3D self-assembly of graphene oxide and stimuli-responsive polymers for high-performance graphene-based supercapacitors
Authors: Zhao Ranran , Li Ke , Liu Runze , Sarfraz Mansoor , Shakir Imran , Xu Yuxi
Published: August 2017

The assembly of graphene into functional macrostructures has attracted intense interest in recent years.
A self-generated and degradation-resistive cratered stainless steel electrocatalyst for efficient water oxidation in a neutral electrolyte
Authors: Lee Minoh , Jeon Hyo Sang , Lee Si Young , Kim Haeri , Sim Sang Jun , Hwang Yun Jeong , Min Byoung Koun
Published: August 2017

The chemical composition change of Ni and Fe on a cratered stainless steel surface as a result of electrochemical oxidation leads to significantly enhanced water oxidation properties in a neutral electrolyte.
Trastuzumab-decorated nanoparticles for in vitro and in vivo tumor-targeting hyperthermia of HER2+ breast cancer
Authors: Hamzehalipour Almaki Javad , Nasiri Rozita , Idris Ani , Nasiri Mahtab , Abdul Majid Fadzilah Adibah , Losic Dusan
Published: August 2017

In this study, a magnetic core–shell modified tumor-targeting nanocarrier (MNPs-PEG–TRA) was engineered and demonstrated for the efficientin vitroandin vivohyperthermia treatment of breast cancer.
Hydrogen-bonding induced melamine-core supramolecular discotic liquid crystals
Authors: Guo Ling-Xiang , Liu Yu-Han , Wang Li , Wang Meng , Lin Bao-Ping , Yang Hong
Published: August 2017

A variety of hydrogen-bonding induced melamine-core supramolecular discotic liquid crystals possessing hexagonal columnar, rectangular columnar and square columnar phases are described.
Spin-dimer networks: engineering tools to adjust the magnetic interactions in biradicals
Authors: Borozdina Yulia B. , Mostovich Evgeny A. , Cong Pham Thanh , Postulka Lars , Wolf Bernd , Lang Michael , Baumgarten Martin
Published: August 2017

Magneto-structural correlations in stable organic biradicals have been studied on example of weakly exchange coupled models with nitronyl nitroxide and imino nitroxide spin-carrying entities.
Effect of deoxynivalenol on apoptosis, barrier function, and expression levels of genes involved in nutrient transport, mitochondrial biogenesis and function in IPEC-J2 cells
Authors: Liao Peng , Liao Meifang , Li Ling , Tan Bie , Yin Yulong
Published: August 2017

DON could affect apoptosis, barrier function, nutrient utilization, as well as mitochondrial biogenesis and function-related gene expression in the IPEC-J2.
Swallowing Mechanics Associated With Artificial Airways, Bolus Properties, and Penetration–Aspiration Status in Trauma Patients
Authors: Dietsch Angela M. , Rowley Christopher B. , Solomon Nancy Pearl , Pearson, William G.
Published: August 2017

Purpose

Artificial airway procedures such as intubation and tracheotomy are common in the treatment of traumatic injuries, and bolus modifications may be implemented to help manage swallowing disorders. This study assessed artificial airway status, bolus properties (volume and viscosity), and the occurrence of laryngeal penetration and/or aspiration in relation to mechanical features of swallowing.

Method

Coordinates of anatomical landmarks were extracted at minimum and maximum hyolaryngeal excursion from 228 videofluoroscopic swallowing studies representing 69 traumatically injured U.S. military service members with dysphagia. Morphometric canonical variate and regression analyses examined associations between swallowing mechanics and bolus properties based on artificial airway and penetration–aspiration status.

Results

Significant differences in swallowing mechanics were detected between extubated versus tracheotomized (
D
= 1.32,
p
< .0001), extubated versus decannulated (
D
= 1.74,
p
< .0001), and decannulated versus tracheotomized (
D
= 1.24,
p
< .0001) groups per post hoc discriminant function analysis. Tracheotomy-in-situ and decannulated subgroups exhibited increased head/neck extension and posterior relocation of the larynx. Swallowing mechanics associated with (a) penetration–aspiration status and (b) bolus properties were moderately related for extubated and decannulated subgroups, but not the tracheotomized subgroup, per morphometric regression analysis.

Conclusion

Specific differences in swallowing mechanics associated with artificial airway status and certain bolus properties may guide therapeutic intervention in trauma-based dysphagia.
Analysis and design of an unequal termination impedance power divider with bandpass filtering response
Authors: Kim P. , Chaudhary G. , Jeong Y.
Published: August 2017

The design of an unequal termination power divider (PD) with a bandpass filtering response and wide out‐of‐band suppression characteristics is presented. The two‐cascaded coupled lines can be designed with a low impedance transforming ratio. For the validation, a 50‐to‐5 Ω termination impedance PD was implemented at a centre frequency (f0) of 2.6 GHz. The measured results are in good agreement with the simulations, showing input and output return losses that are better than 19 dB over a passband bandwidth of 190 MHz (2.51–2.7 GHz), and an out‐of‐band suppression that is better than 19.6 dB from DC to 2.25 and 2.9 to 7.2 GHz. The isolation between the output ports is 39.2 dB at f0, and it is better than 19 dB with a broadband frequency (DC to 7.2 GHz).
Overview of magnetless brushless machines
Authors: Lee Christopher Ho Tin , Chau Kwok Tong , Liu Chunhua , Chan Ching Chuen
Published: August 2017

Owing to the definite merits of high‐efficiency and high‐power density, the permanent‐magnet (PM) brushless machines have been dominating the high‐performance industrial applications. However, the problems of high PM material cost, fluctuating supply of rare‐Earth materials and ineffective PM flux control have hindered the widespread applications of the PM brushless machines. In recent years, many attentions have been shifted to the magnetless candidates, while the focuses are mainly placed on the classical candidates. In this study, an overview of magnetless brushless machines including both the classical and advanced types is presented, with emphasis on their machine topologies, features and performances. In addition, the upcoming trend of these machines is reviewed and discussed.
Energy management of a dual‐mode power‐split powertrain based on the Pontryagin's minimum principle
Authors: Ahmadizadeh Pouyan , Mashadi Behrooz , Lodaya Dhaval
Published: August 2017

A new dual‐mode power‐split device is introduced in this study for application in the transmission system of hybrid electric vehicles. The new system provides two modes of operation and a supervisory control strategy is responsible to determine the vehicle's present operating mode. Based on the selected mode, which is done according to the driving conditions, maximum efficiency and minimum fuel consumption are achieved. Pontryagin's minimum principle has been applied for designing an optimal control strategy during which the Hamiltonian is minimised. The Hamiltonian is calculated by using Pareto maps which provide best operating points of the engine according to the power demand. The simulation results show improvements in fuel consumption for the new system in comparison to the Toyota Hybrid System as the first commercialised and the most accepted and popular power‐split powertrain system.
Traffic flow data compression considering burst components
Authors: Feng Shuo , Ke Ruimin , Wang Xingmin , Zhang Yi , Li Li
Published: August 2017

Many recent applications of intelligent transportation systems require both real‐time and network‐wide traffic flow data as input. However, as the detection time and network size increase, the data volume may become very large in terms of both dimension and scale. To address this concern, various traffic flow data compression methods have been proposed, which archive the low‐dimensional subspace rather than the original data. Many studies have shown the traffic flow data consist of different components, i.e. low‐dimensional intra‐day trend, Gaussian type fluctuation and burst components. Existing compression methods cannot compress the burst components well and provide very limited choices of compression ratio (CR). A better compression method should have the ability to archive all the dominant information in different components of traffic flow data. In this study, the authors compare the influence of different data reformatting, archive the bursts defined before in descending order with respect to the absolute value of the burst points and propose a flexible compression framework to balance between burst components and low‐dimensional intra‐day trend. Experimental results show that the proposed framework promotes the reconstruction accuracy significantly. Moreover, the proposed framework provides more flexible choices with respect to CR, which can benefit a variety of applications.
Dual crescent‐shaped slot antenna fed by circular polarisation into dual orthogonal strip lines
Authors: Abed Amer T. , Singh Mandeep S. Jit , Islam Mohamed T. , Khaleel Aymen D.
Published: August 2017

In this research, a novel single‐layer dual crescent‐shaped slot antenna is fed by circular polarisation into dual orthogonal strip lines for worldwide interoperability for microwave access (Wi‐Max) and wireless fidelity (Wi‐Fi) applications. One phase of the feed strip lines is shifted by 90° to enhance the circular polarisation. The surface current and the effect of changing the dimensions for the parameters are carefully studied to optimise the dimensions of the proposed antenna to satisfy the specifications of the wireless local area network/Wi‐Fi standards of (2.4– 2.484)/(5.15–5.825) GHz and Wi‐Max standards of (2.5–2.6)/(3.4–3.6)/(5.25–5.85) GHz. Several of the critical design parameters, such as return loss, radiation pattern, polarisation, axial ratio bandwidth, and gain are also investigated.
Efficient topology discovery algorithm for software‐defined networks
Authors: Tarnaras George , Athanasiou Fanouria , Denazis Spyros
Published: August 2017

Software‐defined networking (SDN) already has an established presence in the networking industry as an emerging paradigm for designing network architectures, decoupling the control from the forwarding plane and offering a centralised way of network management. Cloud and enterprise infrastructure engineers have already adopted such techniques for building up their environments, deliberating the cost and flexibility advantages gained from this technology. However, smaller companies may choose a progressive replacement of their equipment due to operational and budget constraints. Hence, mixing equipment could lead up to hybrid SDN environments making network management even more complex. In this study, an event‐based generic topology discovery algorithm, capable of providing an efficient packet discovery mechanism using existing protocols in SDN networks, is proposed. For testing and evaluation purposes, address resolution protocol and link layer discovery protocol are being used to extract the information needed and reconstruct the topology to the controller. Implementation is accomplished using Internet Engineering Task Force's ForCES framework.
Closed‐loop control of the grid‐connected Z‐source inverter using hyper‐plane MIMO sliding mode
Authors: Zakipour Adel , Shokri Kojori Shokrollah , Tavakoli Bina Mohammad
Published: August 2017

In this study, a hyper‐plane multi‐input–multi‐output (MIMO) sliding‐mode controller (SMC) is presented for control of the grid‐connected Z‐source inverter (ZSI). The presented controller can simultaneously control all of the system state variables including grid‐side AC current and DC‐link capacitors voltage. These state variables are directly regulated by amplitude modulation index and shoot‐through interval. The non‐minimum phase problem of the capacitors voltage is solved by indirect regulation of the DC‐side inductor current. The proposed controller is developed using non‐linear MIMO model of the converter; hence, it is possible to apply the proposed controller in a wide operating range. Controller coefficients are designed using Jacobian linearisation approach to ensure stability of the system. According to application of the Lyapunov approach, it is proved that the proposed controller is asymptotically stable against changes of the system state variables. Some simulations are presented to verify the effectiveness and stability of the developed controllers by MATLAB/Simulink toolbox. Also, a laboratory prototype is implemented using a digital signal processor TMS320F28335. Experimental results are given for the presented controller in the single‐phase ZSI. It is seen that the experimental and simulation results are in good agreement.
Dynamic reactive power optimal allocation to decrease wind power curtailment in a large‐scale wind power integration area
Authors: Niu Tao , Guo Qinglai , Jin Hongyang , Sun Hongbin , Zhang Boming , Liu Haitao
Published: August 2017

Autonomous voltage security regions (AVSRs) have been proposed to prevent cascading trip faults in wind farms. However, due to insufficient dynamic reactive power (DRP) support and unreasonable DRP allocation in large‐scale, centralised wind power integration areas, especially for high wind power penetrations, AVSRs may be too small to guarantee secure wind farm operation, resulting in large amounts of wind power curtailment. DRP allocation is crucial for wind farms to accommodate more wind power and decrease curtailment. Therefore, a DRP allocation scheme based on the AVSR to accommodate more wind power is proposed in this work. An improved AVSR considering wind power curtailment is first derived; the function between the AVSR, DRP reserves and curtailment is then obtained, and an optimal DRP allocation scheme using Benders decomposition is finally proposed. Good performance is observed when tested on a real large‐scale wind power base in Northern China.
Outcomes of Patients with Behçet's Syndrome after Pulmonary Endarterectomy
Authors: Yıldızeli Şehnaz , Yanartaş Mehmed , Taş Serpil , Direskeneli Haner , Mutlu Bülent , Ceyhan Berrin , Yıldızeli Bedrettin
Published: August 2017

Background Behçet's syndrome (BS) is a multisystem disorder and is not known as a risk factor for chronic thromboembolic pulmonary hypertension (CTEPH), for which the treatment of choice is pulmonary endarterectomy (PEA). The aim of this study was to review our experience in the surgical treatment of CTEPH in patients with BS.

Methods Data were collected prospectively for consecutive patients with BS who underwent PEA over a 6-year period.

Results We identified nine patients (seven males, two females, mean age: 34.7 ± 9.9 years) with BS. The mean disease duration before PEA was 88.0 ± 70.2 months. All patients but one received immunosuppressive therapy before the surgery. Exercise-induced dyspnea presented symptoms in six patients. One patient had associated intracardiac thrombosis. PEA was bilateral in five patients, unilateral in three, and lobar in one. No perioperative mortality was observed; however, one patient died four weeks after PEA due to massive hemoptysis. Morbidity was observed in two patients. The systolic pulmonary artery pressure fell significantly from 59.0 ± 22.7 mm Hg to 30.0 ± 6.5 mm Hg after surgery (p = 0.031). Pulmonary vascular resistance also improved significantly from 611.8 ± 300.2 to 234.7 ± 94.9 dyn/s/cm5 (p = 0.031). After a median follow-up of 29.4 months, all patients improved to the New York Heart Association (NYHA) functional class I and II.

Conclusion Patients with BS may suffer recurrent pulmonary embolism and develop CTEPH. In patients who do not respond to anticoagulation or immunosuppressive therapy, PEA may be a therapeutic option when thrombotic lesions are surgically accessible. Due to the high risk of perioperative mortality, the procedure should be undertaken in centers with experience.
Außerklinische Beatmung – Konzepte und Therapieempfehlungen
Authors: Schwarz Sarah , Magnet Friederike , Schönhofer Bernd , Windisch Wolfram
Published: August 2017

The prognosis of patients receiving home mechanical ventilation is very heterogeneous and depends on the underlying disease, the degree of respiratory dependency and the comorbidities. Due to the severe chronic diseases, the initiation of a long-term NIV must be done during an inpatient treatment. Two recently published randomized controlled trials using more aggressive forms of NPPV targeted at normalizing hypercapnic PaCO2 values, showed improved long term survival also in patients with an underlying diagnosis of COPD. Consequently, the number of patients receiving home mechanical ventilation has dramatically increased in recent years and more and more outpatient settings has been established without scientific evidence. Nevertheless, beside reliable care structures, ethical aspects and health related quality of life are of great importance in the context of home mechanical ventilation.
Duale antithrombozytäre Therapie – Perioperativ absetzen oder weiterführen?
Authors: Koscielny Jürgen , von Heymann Christian , Zeymer Uwe , Cremer Jochen , Spannagl Michael , Labenz Joachim , Giannitsis Evangelos , Goss Franz
Published: August 2017

Hintergrund Bei Patienten nach akutem Koronarsyndrom wird die duale antithrombozytäre Therapie (DAPT) mit Acetylsalicylsäure und einem P2Y12-Adenosindiphosphat-Rezeptorblocker wie Clopidogrel, Prasugrel und Ticagrelor für eine Dauer von 12 Monaten in den Leitlinien empfohlen. Wenn diese Hochrisikopatienten sich einem chirurgischen Eingriff unterziehen müssen, herrscht oft Unsicherheit bezüglich der DAPT: Kann die Therapie ohne Unterbrechung fortgeführt werden? Wenn nein, welches Therapie-Karenzkonzept wird empfohlen? Was muss beim perioperativen Management beachtet werden?

Methoden Eine interdisziplinäre Gruppe erfahrener Experten aus den Bereichen Kardiologie, Kardiochirurgie, Gastroenterologie, Anästhesiologie, Intensivmedizin und Hämostaseologie hat auf Basis der aktuellen wissenschaftlichen Datenlage praxisrelevante Informationen und Empfehlungen erarbeitet.

Ergebnisse Die Empfehlungen schließen Hinweise für die Einschätzung des Patienten- und Operations-spezifischen Blutungs- und Ischämierisikos, generelle Hinweise bezüglich des Karenzkonzeptes der DAPT und konkrete Empfehlungen hinsichtlich Thrombozytenfunktionshemmung bei häufigen chirurgischen Eingriffen ein.

Diskussion Diese Zusammenstellung soll allen beteiligten medizinischen Disziplinen den Umgang mit Patienten unter DAPT erleichtern und damit eine optimale perioperative Versorgung der Patienten gewährleisten.
Wurzelextrakt als pflanzlicher Immunmodulator
Authors: Andres Ulrike
Published: August 2017

Es ist schwierig, die Immunkompetenz in Studien umfassend zu beschreiben, weil sie von vielen Faktoren beeinflusst wird. Hierzu gehören das Alter, Stress und Krankheiten. Deshalb sollte ein geeignetes Messverfahren der Immunkompetenz mehrere Parameter gleichzeitig berücksichtigen.
Fahreignung bei Morbus Parkinson
Authors: Buhmann Carsten , Vesper Jan , Oelsner Henriette
Published: August 2017

Etwa 60 % aller Parkinson-Patienten und 50 % der Parkinson-Patienten mit Tiefer Hirnstimulation (THS) und Führerschein fahren aktiv Auto.
Parkinsonerkrankte weisen jedoch häufig körperliche und/oder psychische Einschränkungen mit potentiellem Verlust der Fahreignung (syn.
Fahrtauglichkeit) auf. Die Fahrfähigkeit (syn. Fahrtüchtigkeit) kann auch durch Parkinson-Medikamente eingeschränkt sein. Vom behandelnden
Arzt wird verlangt, seine Patienten hinsichtlich ihrer Fähigkeit, ein Kraftfahrzeug zu führen, zu beraten. Dies ist jedoch in der Praxis
schwierig. Zum einen gibt es keine standardisierte, prädiktive Testbatterie zur Beurteilung der Fahreignung, zum anderen korreliert die
Ausprägung der motorischen Einschränkung nur unzureichend mit der Fahreignung. Dieser Artikel gibt einen Überblick, welche motorischen und
nicht-motorischen Symptome die generelle Fahreignung und/oder die situativ-geprägte Fahrfähigkeit bei M. Parkinson beeinträchtigen können,
welche Kriterien eine relative oder absolute Fahruntauglichkeit anzeigen, welche neuropsychologischen Untersuchungen sinnvoll sind und wie
Patienten mit THS hinsichtlich der Fahreignung zu bewerten und zu beraten sind.