bluuebunny/crossref_metadata_2025 huggingface dataset:
Dialogue and polemics of S. A. Yesenin and N. A. Klyuev about art
Authors: Seregina Svetlana A.
Published: April 2022

The paper analyzes conceptual rapprochements between N. A. Klyuev and S. A. Yesenin in their understanding of the role of art (the chronological framework of the study is limited by 1919). The following stand out as the main ideas uniting the poets: art in its development should contribute to the formation and strengthening of the national cultural and historical tradition; national art implies convergence of Christianity and paganism, providing not only spiritual, but also a truly creative synthesis; art is a sacrificial path, implying suffering and dedication; an artist (poet) is a prophet and visionary deeply connected with the fate of the motherland, yet at the same time his mission is addressed to all mankind; a creator is searching to synthesize art and religion. The differences in Klyuev's and Yesenin's understanding of the main tasks of art are considered separately. For Klyuev, genuine art is sanctified by the moral values of Christian culture, the main of which is the path to spiritual transformation. For Yesenin, the dialectic of art is based on the dialogue of the idea of the “nodal ovary of nature with the essence of man” and the poet's belief in the fusion of the “other world with the visible world”. The study also pays special attention to the controversy of Klyuev and Yesenin over the boundaries of art.
To the issue of illustrating the Holy Scriptures in Russia by example of subjects from the Pentateuch of Moses
Authors: Mikhailova Natalia V.
Published: April 2022

Due to the historical and artistic features of the text of the Old Testament, illustrating its books has always been a difficult task, and this problem is particularly acute in Russia at the present. In the absence of high-quality series of illustrations by modern Russian authors, publishers resort to using the works by European and American artists, as well as works by Russian masters of past centuries, which leads to incorrect interpretation of the text by readers. The only experience in creating a full-fledged cycle of illustrations by a domestic author, which has become widespread and is used as a model up to the present day, are the works of an artist of the 19th century. A. A. Agin. However, the time of creation of these works and the academic training of the author affected the historical accuracy of the details of some images and the phenotype of the characters. As for the illustration of the Old Testament as a whole, the issue of distortion of spiritual and edifying meanings in illustrations of Old Testament events, as well as the problem of historical and cultural unreliability of the image, is considered using the example of the most characteristic scenes from the Pentateuch of Moses. The two most common stories in the illustrated Bibles that have been misinterpreted in the mind of general reader are the worship of the cast calf at Mount Sinai and the meeting of Eliezer and Rebekah. In some cases, not only the compositional features of the illustration, but also its color scheme, become a problem for understanding the Holy Text. Which is the case with children's Bibles, widely published in Russia in the 90s. 20 century, the meaning of Joseph's multi-colored clothes is almost completely lost. The author considers the issue of distortion of spiritual and edifying meanings in the illustrations of Old Testament events, as well as the problem of historical and cultural unreliability of the image on the example of the most common or characteristic subjects from the Pentateuch of Moses. The creation of modern illustrations to the Old Testament in Russia is an important task that needs to be solved in the joint large-scale work of theologians, historians, cultural scientists, philologists and artists.
Musical folklorism in the works of A. Nizhnik: modern forms of the actualization of folklore
Authors: Kaminskaya Elena A.
Published: April 2022

The interaction of folk and professional culture is widely manifested in modern times. One of the indicative phenomena of such interaction is a musical folklorism. It is refracted in various ways in the work of each composer. The focus of the national musical culture on the refraction of folklore traditions has been established since the 19th century, when the authentic material was processed following the author's artistic intent. That said modern musical culture shows that, despite active metamorphoses of the musical language, often far from the traditional sound, the musical folklorism manifests itself quite actively. That is why it is so important to turn in terms of the research on musical culture to those works in which the specificity of composer creativity is clearly displayed and modern sounds and the authentic folklore texts intertwine. One of these works was the orchestral composition of the contemporary composer Artem Alexandrovich Nizhnik “Karagody of Spring”. It reflects basic principles of working with a folklore source, first of all citation, transformation of the folklore motives, stylization as folklore (an essay “in the spirit of”). All this enriches the author's creative method with new original ideas. The composer's work is an example of a sensitive approach and careful attitude towards folklore, professional work with authentic texts. For the folklore itself it implies a live sound in modern concert practices as one of the forms of its actualization.
“Yes, Sonyushka, and say what you will, I`m only living on your letters …”: daily life in camp and survival strategy of N. P. Antsiferova (review: Nikolai Antsiferov. “This is our life in letters”: letters to family and friends (1900–1950s). Moscow, New literary review, 2021. 640 p.)
Authors: Polyanskaya Tatiana M.
Published: April 2022

Camp letters are one of the most objective sources in the study of the GULAG prisoners’ everyday life. On the basis of specific quotations from N.P. Antsiferov's letters, the working and living conditions of the camp population of the Baikal-Amur ITL in the late 1930s are considered; Antsiferov's testimonies are compared with the official documentation of the NKVD and the GULAG. The author of the article compares the way of thinking of Nikolai Antsiferov and Varlam Shalamov, as one of the most popular writers about the life of prisoners in correctional labor camps. The article for the first time gives an assessment of the N.P. Antsiferov's epistolary heritage in the study of the history of the GULAG and political repression during the years of Stalin's rule.
Representation of the wedding tradition of the 60-s of the 20th century in the Voronezh region (Ethnolinguistic Aspect)
Authors: Nedostupova Lubov V.
Published: April 2022

This research presents content and routine of the wedding ceremony. The aim of the paper is to reconstruct the traditional custom from surviving memories of eyewitnesses and to identify the accompanying vocabulary in the village of Vysoky of the Talovsky district. The novelty of the study is due to the fact that for the first time a large ceremony was recorded and described in detail in a small village, which had not previously been recorded in any of the surveyed settlements of the Voronezh region. It can be safely considered an original performance. The representation of the ritual is made as an image of tradition through language, tradition in language. As a result, unusual for the 21st century features of a wedding were obtained, consisting of 22 different stages, interconnected with each other, and the vocabulary instrumental in providing insight into content of the main custom of the family cycle. The study specifies that meanings and ideals embedded in the reproduced content have now changed. The practical significance of the work lies in the fact that unique information can be used as the basis for collecting of original family cycle rituals belonging to villagers and existing in the 20th century.
The core of the cultural code of the Russian people as a deterrent to ressentiment
Authors: Isachenko Nadezhda N.
Published: April 2022

In recent decades, the idea of recognizing resentment as a characteristic feature of the Russian people has been strongly implanted in a collective consciousness, producing a negative impact on the formation of the image of Russia, the people, and undermining the country's authority, both in the world community and in the eyes of its own citizens. In this regard, the paper looked to determine the validity of such a statement. To meet this objective the author involved an extensive material on Russian culture and specifics of the Russian people`s character in a cultural and historical context: from Ancient Russia to the modern stage of civilizational development. The character of the Russian people and its cultural code have been formed over the centuries, enriched by their own and world experience under the influence of various factors. It was determined that, as in any other country, ressentiment emerged at crucial moments in the state`s history: during wars, revolutions, crises accompanied by the transformation of the value system, the crisis of culture. Russian culture is characterized by tolerance, kindness, forgiveness, generosity, mercy, compassion, which gives grounds to the following idea: envy, hatred, meanness, and revenge, which contribute to the formation of ressentiment, are not characteristic for a Russian person, therefore, ressentiment is not a characteristic feature of the Russian people. The paper articulates the idea that any position that asserts ressentiment as a characteristic feature of a nation or ethnic group, is a delusion. Resentment is formed in the presence of unfavorable socio-economic and cultural conditions in individual individuals, groups, marginal communities outside of belonging to a particular nation or ethnic group. Still the modern society gives shelter to the factors that contribute to the formation of ressentiment and its dissemination through information and communication technologies. The paper comes up with methods of preventing ressentiment.
Serbian colony in Bessarabia in the 19 century
Authors: Grosul Vladislav Ya.
Published: April 2022

Over the centuries, the Serbs have repeatedly established their colonies and even inhabited localities in Moldova. A new stage in Serbian-Russian-Moldovan relations begins in the 19 century. As early as in November 1804, a Serbian delegation headed by one of the prominent figures of the rebels, Archpriest Matvey Nenadovich, went to Russia. At that time, Moldova acted as a connecting linker between the Serbs and Russia. Moldavia, as well as Wallachia, began to play a significant role in Serbian–Russian relations after joining in 1806. Russia's war with Napoleon with ensuing withdrawal of the Danube army to fight him resulted in the fact that at that time Russian-Serbian ties were reduced to a minimum. In the autumn of 1813, the Turks attacked the Serbs, captured Belgrade and crushed the First Serbian Uprising. Many of its leaders fled to Austria where were interned. Among them was Karageorgiy, who in 1814 with a number of his supporters moved to Russia and settled in Bessarabia. The governor of the Bessarabian region, engineer Major-General Garting, anticipated a potential intention of Serbs to settle in Bessarabia on empty state lands. From archival materials, you can also learn some details of the establishment of Serbs in Russia. According to the testimony of the Russian ambassador to Austria, Stackelberg, it follows that the Austrian government wanted the settlement of Serbs far from its borders, fearing the discontent of the Turkish authorities, with whom Austria had appropriate peace treaties. Bessarabia was connected with Serbia via some other channels. In October 1875, the daughter of Moldovan colonel in the Russian service, Peter Ivanovich Keshko, and Pulcheria Sturdza — Natalia Keshko became the wife of Serbian Prince Milan Obrenovich and later on, after her husband Milan Obrenovic became King of Serbia in March 1882, she became queen. She came to be the first and only Moldavian queen.
A Comprehensive Review on some Species of Mikania
Authors:   Department of Pharmaceutics, School of Pharmaceutical Sciences, IFTM, University, Moradabad, Uttar Pradesh, Singh Mukesh Kr
Published: April 2022

Mikania is a genus of about 430 species belongs to family of Asteraceae. However, less than 10% of these species have been investigated. Amongst these, M. cordata, M. laevigata Schultz Bip. ex Baker and M. glomerata Spreng are considered medicinally important. Moreover, these herbs found their place for the treatment of flue, rheumatism and gastrointestinal disorders. The chemical studies have underlined the presence of various compounds; the main being terpenoids, flavonoids, volatile oil, carbohydrates and acids. Their extracts as well as pure isolated compounds, showed multiple pharmacological activities such as antiinflammatory, respiratory tract diseases, antiulcer, antidiarrhoeal, antispasmodic, antimicrobial and others
Immunological mechanisms in multiple spontaneous cervical artery dissection: An illustrative case and review of the literature
Authors:   Department of Neurology, University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania, Bajko Zoltan , Maier Smaranda ,   Department of Neurology, University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania, Motataianu Anca ,   Department of Neurology, University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania, Filep Rares Cristian ,   Department of Interventional Radiology, Mures County Clinical Emergency Hospital, Targu Mures, Romania, Stoian Adina ,   Department of Patophysiology, University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania, Barcutean Laura ,   Department of Neurology, University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania, Andone Sebastian ,   Department of Neurology, University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania, Balasa Rodica ,   Department of Neurology, University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania
Published: April 2022

Dissection of the cervical arteries is the leading cause of stroke in young adults, yet the etiology and pathogenesis of this event remain unclear. However, a growing number of data in the literature support the potential implications of immunological mechanisms in the pathogenesis. Several large patient groups and multicentre cohorts have reported significant associations with recent infections and elevated inflammatory markers. There are also several case reports and case series suggesting an association with various autoimmune disorders and viral infections. Some case reports have also detailed cervical artery dissections linked to the use of biological therapies for other pathologies. In the present case, a 38-year-old female patient with triple spontaneous cervical artery dissection presented multiple potential trigger factors as recent infection, autoimmune thyroid disease, primary thrombophilia and hyperhomocysteinemia. This report sought first presents this case, and then reviews the existing relevant literature data regarding the potential immunological mechanisms implicated in the pathogenesis of cervical artery dissection.
Cavernoma in the medulla oblongata – Case presentation and review of the literature
Authors:   Neurology Department, Colentina Clinical Hospital, Bucharest, Romania, Ilie Dumitrita-Mirela , Parvu Delia Adriana ,   Neurology Department, Colentina Clinical Hospital, Bucharest, Romania,   Affidea-Hiperdia SA, Bucharest, Romania, Bargau Ana Maria ,   Neurology Department, Colentina Clinical Hospital, Bucharest, Romania, Gheorghisenco Elena ,   Neurology Department, Colentina Clinical Hospital, Bucharest, Romania, Nica Sanda Maria ,   Neurology Department, Colentina Clinical Hospital, Bucharest, Romania,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, Mihailescu Gabriela ,   Neurology Department, Colentina Clinical Hospital, Bucharest, Romania,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
Published: April 2022

Cerebral cavernous venous malformations (also called cavernous hemangiomas or cavernomas) are the third most common cerebral vascular malformations having an incidence of 0.4-0.8% in the general population and being diagnosed more frequently incidentally during an imaging procedure. Usually solitary, but cavernomas can also be present as multiple lesions with autosomal dominant inheritance pattern. We present a rare case and the MRI imaging of a type I Zabramski cavernoma that bled, localized in the medulla oblongata of a 41-year-old man, admitted with paresthesia of the right upper limb, very mild right hemiparesis and impaired fine motor movements of the right hand and intractable persistent hiccups.
Diagnostic challenges in Goldenhar syndrome – a case report
Authors:   Department of Obstetrics and Gynecology, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Pariza Paul Costin , Dima Vlad ,   Filantropia Clinical Hospital, Bucharest, Romania, Grigoriu Corina ,   Department of Obstetrics and Gynecology, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania, Berceanu Costin ,   Department of Obstetrics and Gynecology, Craiova University of Medicine and Pharmacy, Craiova, Romania, Georgescu Tiberiu-Augustin ,   Department of Pathology, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Mihai Bianca-Margareta ,   Filantropia Clinical Hospital, Bucharest, Romania, Gheorghe Consuela-Madalina ,   Department of Marketing and Medical Technology, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Bohiltea Roxana Elena ,   Department of Obstetrics and Gynecology, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania
Published: April 2022

Goldenhar syndrome, also known as oculo-auriculo-vertebral syndrome, represents a rare congenital complex of anomalies, involving the development of the first and second brachial arches during the first embryonary stage. In addition to the craniofacial disorders, Goldenhar syndrome can include central nervous system, heart, skeleton or kidneys pathologies as well as vertebral defects. We present the case of a Goldenhar syndrome whose first pathologic sign was tetralogy of Fallot, with associated cardiovascular disorders (atrial septal defect type ostium secundum, and single umbilical artery) and bilateral microtia, with malformation of auditory canal, mandibular hypoplasia and a single epibulbar dermoid. The Goldenhar syndrome was diagnosed after birth, the article emphasizing the difficulties of prenatal diagnosis.
Biodegradable Polymers for Packaging : A Bibliometric Overview of the Publication in Web of Science in Year 2012-2021
Authors: Pavithra Siva  , Mohammad Ali Tareq  , Kamyar Shameli
Published: April 2022

This is a bibliometric analysis study of biodegradable and packaging by studying the documents related to biodegradable field.The use of polymer packaging increased due to its several desired properties such as softness , lightness ans transparency. However , the non biodegradability of polymer packaging only led to a serious ecological problems.Although complete replacement of polymer packaging with biodegradable packaging is quite impossible , still production of biodegradable packaging will reduce the need for synthetic polymer packaging.A lot of studies has been done regarding to the biodegradable and packaging started to attract people from various counties such as China , India and USA. An analysts has been done in this paper by extracting data from WOS database and visualise through VOSviewer to study the collaboration network, topics of interest and impact of publications. Findings reveals that the collaboration work is strong between China and USA as both countries are successful in scientific knowledge technology. This study expected to have an impact for future environment on biodegradable and packaging field.
Isolation and characterization of alkane hydrocarbons-degrading Delftia tsuruhatensis strain D9 from petroleum-contaminated soils
Authors: EREN Ayşe , GÜVEN Kemal
Published: April 2022

A bacterial strain from petroleum-contaminated soil in south-eastern Turkey was isolated and characterized to determine the potential of alkane hydrocarbon biodegradation. Phenotypic characteristics and the sequence analysis of the 16S rRNA gene revealed that the strain D9 is a member of the Delfitia genus and most similar to Delftia tsuruhatensis (100%). The optimum pH and temperature values for the growth of D. tsuruhatensis strain D9 were found to be 9.0-10.0 and 35°C, respectively. The strain was found to grow in some single, medium and long-chain hydrocarbons such as decane, hexadecane, and squalene, tested by short-time incubation in basal medium (BM) in the presence of 1% hydrocarbon concentrations under optimum conditions. After incubation for 3 days, 65% of the single hydrocarbon hexadecane was degraded by the D. tsuruhatensis strain D9, revealed by GC-MS analysis. The biodegradation of petroleum hydrocarbons by D. tsuruhatensis strain D9 isolated and characterized in the present study shows that it can be a good candidate in the bioremediation process.
HEMŞİRELİK ÖĞRENCİLERİNİN DERS ÇALIŞMA YAKLAŞIMLARININ İNCELENMESİ
Authors: GÖK Fadime
Published: April 2022

Amaç: Bu çalışmanın amacı hemşirelik bölümü öğrencilerinin ders çalışma yaklaşımlarını belirlemek idi. Yöntem: Bu çalışma tanımlayıcı, kesitsel tipte bir çalışmadır. Çalışma 2019-2020 Bahar yarıyılında bir devlet üniversitesinin Sağlık Bilimleri Fakültesi Hemşirelik Bölümü’nde yürütüldü. Çalışmanın evrenini hemşirelik lisans öğrencileri (n=811) oluşturdu. Örneklem seçimine gidilmeden araştırmaya katılmaya kabul eden tüm öğrenciler (n=502) örnekleme dahil edildi. Veriler öğrenci tanıtıcı bilgi formu ve “Ders Çalışma Yaklaşımı Ölçeği” aracılığı ile toplandı. Verilerin değerlendirilmesinde sayı, yüzde, ortalama, standart sapma, Independent Samples ttest, One-Way Anova, Mann Whitney U ve Kruskal Wallis testleri kullanıldı. Bulgular: Öğrencilerin yaş ortalaması 20.41±1.64 olup, %83,7’si kadındı. Ders Çalışma Yaklaşımı Ölçeği puan ortalaması karşılaştırıldığında yaş, cinsiyet, öğrenim gördüğü sınıf, ekonomik durum, şu an yaşadığı yer, çalışma ortamı ve çalışma materyaline sahip olma durumu arasında istatistiksel olarak anlamlı fark olduğu saptandı. Yirmi bir yaş üstü, erkek, üçüncü sınıfta okuyan ve öğrenci evinde kalan öğrencilerin yüzeyel motivasyonları daha yüksek olarak belirlendi. Ekonomik durumu iyi olan ve uygun çalışma ortamı olan öğrencilerin derin stratejiyi benimsediği ve yardımcı çalışma materyaline sahip olan öğrencilerin ise derin motivasyonlarının daha iyi olduğu görüldü. Sonuç ve öneriler: Araştırma kapsamına alınan öğrencilerinin derin motivasyon düzeyleri düşük olmakla birlikte, ders çalışmada ağırlıklı olarak derin strateji ve derin yaklaşımı tercih ettikleri tespit edildi. Çalışmanın daha geniş örneklem grubunda tekrarlanması önerilmektedir. Anahtar Kelimeler: Hemşirelik eğitimi, öğrenci, öğrenme, ders çalışma yaklaşımları
USING MQTT PROTOCOL TO CONTROL THE COMBI BOILERS OF OPENTHERM COMPATIBLE
Authors: TEOMAN Erçin , AKKAN Özlem
Published: April 2022

Since the first years of humanity, heating still maintains its place as one of the most basic needs for home comfort. In future, we have to create communication network that will enable heating systems to work more efficiently and comfortably. Combi boiler is a device used both for heating domestic water and for heating needs The OpenTherm Protocol was created by combi boiler manufacturers. This protocol provides the opportunity to control combi boiler from different brands using the same communication language. When wireless communication is required, frequently, we see that the OpenTherm protocol is used as RF, but there are too many breaks in this setup. It is not possible to fully communicate with the heating area. System that installed over a Wi-Fi with TCP/IP based MQTT will be better than RF. MQTT is a communication protocol frequently used about used in IOT applications MQTT is a protocol that uses TCP/IP infrastructure and can meet all our communication needs for OpenTherm without any problems. Keywords: MQTT, OpenTherm, IoT, TCP/IP, Combi Boiler.
MACITENTAN: THE EVOLUTION OF THE CLASS ENDOTHELIN RECEPTOR ANTAGONISTS TO IMPROVE EFFICACY AND SAFETY OF PAH TREATMENT
Authors: Martynuk T. V. , Nakonechnikov S. N. , Chazova I. Ye.
Published: April 2022

Pulmonary arterial hypertension (PAH) is a severe progressive disease, characterized by advanced remodeling of small pulmonary arteries and arterioles, which ultimately leads to right heart failure and death. Due to discovery of PAH pathophysiological targets, new medications have been developed and implemented into clinical practice. These medications compensate the deficiencies of endogenous prostacyclin and nitric oxide and also block the effects of endothelin-1 (ET-1). The role of the latter in PAH pathophysiology is related to its strong vasoconstrictory properties, as well as to a number of effects responsible for arterial wall remodeling. Clinical use of endothelin receptor antagonists (ERA) started in 2001, with the first agent of the class, bosentan, whose efficacy was demonstrated in a number randomized controlled trials. Macitentan is a novel potent double action oral ERA, developed with the purpose to improve efficacy and safety of PAH treatment through its tissue specificity. The new molecule blocks endothelin receptors type A and B and possesses improved physicochemical properties allowing for improved tissue penetration. Macitentan prevents an increase in pulmonary arterial pressure, right ventricle hypertrophy and improves survival in animal models. The SERAPHIN Study evaluated the effects of macitentan on morbidity/mortality in 742 PAH patients, randomized to macitentan 3 mg or 10 mg daily or placebo. Macitentan 3 mg and 10 mg daily was shown to reduce morbidity and mortality by 30% and 45%, respectively. By 6 month of the follow-up, there was an improvement in 6-minute walking test by + 16.8 m for macitentan 3 mg and +22.0 m for macitentan 10 mg daily. An improvement of the functional class, compared to baseline, was observed by 6 mo in 13% of placebo patients, 20% of macitentan 3 mg daily patients (p=0.04) and in 22% of 10 mg daily patients (0.006). Compared to placebo, macitentan significantly reduced pulmonary vascular resistance and improved cardiac index. It demonstrated a favorable safety profile. US Food and Drug Administration (FDA) approved macitentan (OPSUMIT) 10 mg once daily for the treatment of pulmonary arterial hypertension to delay disease progression.
THE CONCERNS OF ROSUVASTATIN CLINICAL EFFICACY AND SAFETY
Authors: Kukharchuk V. V. , Malyshev P. P.
Published: April 2022

In the article the authors consider some concerns of clinical efficacy and safety of rosuvastatin - the most powerful representative of the group of statins. The review contains the results of clinical trials, demonstrating its high lipid-lowering efficacy, impact on surrogate and primary endpoints in studies on primary and secondary prevention. They also discuss safety treatment concerns with this drug, and its possible side effects. The authors present data on the comparative efficacy and tolerability of generic form of rosuvastatin (Mertenil, Gedeon Richter) which had been received by Russian and foreign researchers, the evidence about the comparability of therapeutic efficacy and safety of the generic to the original form.
RISK STRATIFICATION OF POSTOPERATIVE CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH ACUTE CORONARY SYNDROM
Authors: Shibeko N. A. , Gelis L. G. , Medvedeva E. A. , Ostrovsky Yu. P. , Shumovets V. V.
Published: April 2022

The article presents our research results in creating risk group stratification scores in patients with ACS (183 patients) with expecting coronary artery bypass in conditions of heart-lung bypass. These scores based on the complex evaluation of clinical instrumental and biochemical predictors allow to stratify groups of risk and predicting postoperative cardiovascular complications in patients with ACS with expecting coronary artery bypass more effectively than common EuroSCORE.
THE ORGANIZATION OF MEDICAL CARE FOR ACUTE CORONARY SYNDROME PATIENTS IN PCI CAPABLE AND PCI NON-CAPABLE HOSPITALS FROM 2009-2012
Authors: Oshchepkova E. V. , Dmitriev V. A. , Gridnev V. I. , Dovgalevsky P. Ya.
Published: April 2022

Aim of the study. To evaluate the organization of medical care for acute coronary syndrome (ACS) patients in PCI capable and PCI non-capable hospitals from 2009-2012. Materials. Russian Registry of Acute Coronary Syndromes (ACS Registry) with an internet tracking was created in 2008 year. We performed an observational study of 139 882 ACS patients (56% M, 44% F; av. age - 65 years (56;75) [25%;75%]); ACS with ST elevation pts (ACS STe) - 45 707, ACS non ST elevation pts -84 603. Pts. were hospitalized due to ACS, prospectively enrolled in 167 hospitals from January 2009 to January 2013 in the ongoing ACS Registry. The ACS registry is carried out in cooperation with the Russian Ministry of Health. Results. The majority pts. before ACS had cardiovascular diseases and bad control of arterial hypertension. Many ACS STe pts to correspond for high risk in-hospital and 6-months death (GRACE risk score) (45,4% и 36,7%, accordingly). In 2012 fibrinolysis was used in 30,3% (positive dynamic on 8,3% from 2009). Percutaneous coronary interventions (PCI) for ACS STe pts. were used in 28,2% (primary PCI more than 80% pts). Conclusion. Russian ACS Registry may provide with information concerting characteristics and treatments of ACS pts. in different hospitals from Russia.
CLINICAL VALUE DISTRIBUTION OF POLYMORPHISM OF THE LIPIDTRANSPORT SYSTEMS GENES IN PATIENTS WITH UNSTABLE ANGINA AND CORONARY HEART DISEASE IN FAMILY HISTORY
Authors: Bekmetova F. M. , Kahn L. E. , Khashimov Sh. U. , Trigulova R. Kh. , Shek A. B. , Kurbanov R. D.
Published: April 2022

Aim. To study influence of coronary heart disease (CHD) in family history on distribution of polymorphism apolipoprotein A1, В and E genes of the lipidtransport systems and major adverse cardiac events (MACE) in patients of Uzbek nationality with unstable angina (UA). Material and methods. There were examined 125 patients of Uzbek nationality with UA. I group (n=63) consisted of patients with burdened family history and II group (n=62) without family history. The control group consisted of 58 healthy persons. The G-A polymorphism of apolipoprotein A1 (APO A1) gene, -516C/T polymorphism of apolipoprotein В (APO B) gene and є2/є3/є4 polymorphism of apolipoprotein E (APO E) gene was determined using reagents Diatom TM DNA Prep 200 (production of LLC « IsoGen Laboratory») Results. In studying the distribution of «damaging» alleles of studied genes among the patients with UA in comparison with healthy persons, has been found a more prevalence of A allele carriers of the APO А1 (HR 3,63, 95% CI 1,638,04, P=0,002). The distribution of «damaging» alleles in comparative analysis of the II group with healthy persons did not differ significantly, whereas in I group had significantly greater accumulation of alleles: «А» G-А polymorphism of APO А1 gene (HR 5,99, 95% CI 2,52-14,24,P=0,001), «є4» polymorphism of APO E gene (HR 2,91, 95%, CI 1,12-7,62 P=0,044). At the same time there was no difference in the frequency of carriage «T» allele of -516C / T polymorphism of APO B gene. In patients with carriage of «damaging» alleles it was observed high frequency surgical revascularisations (HR 3,43, 95 %, CI 1,26-9,31, P=0,02) within one year. Conclusion. Presence of CHD in family history among patients of Uzbek nationality with UA is associated with the accumulation of «damaging» alleles: «А» (M1-) G-A polymorphism of APO A1, «є4» of APO E gene, and «D» I/D polymorphism of ACE gene. In patients with carriage of «damaging» alleles it was observed high frequency surgical revascularisations within one year.
OPTIONS TO INVASIVELY ASSESS MYOCARDIAL DEFORMATION PROPERTIES
Authors: Kurlianskaya E. K. , Ostrovsky Yu. P. , Trophimova T. A. , Ratchok L. V. , Denisevitch T. L. , Semyonova N. V.
Published: April 2022

Objective: to evaluate myocardial deformation properties of LV in patients at different terms after heart transplantation. Material and methods: this study encompassed 45 individuals who undergone orthotopic heart transplantation (OHT) and 25 volunteers with no heart disorders. Onstandard heart transthoracic echocardiography (EchoCG), myocardial LV wall deformation (global strain) in four-chambered (LV4GS), three-chambered (LV3GS) and two-chambered (LV2GS) projections was evaluated, and the mean GS was calculated. The studies were performed at the following terms: first one- in a month after OHT, second- 1-6 months after OHT, and the third- at 6-12 months after OHT. Results: LV myocardial deformation properties in patients at different terms after heart transplantation. In 1 month after the OHT in the presence of normal LV EF estimates, the decreased myocardial deformation properties tended to the improvement at 6 months after the operation was registered. The statistically significant positive value dynamics characterizing the myocardial fiber systolic strain was noted at 12 month: absolute estimates of 2GS, 4 GS and GScp increased by 19.9%, 20.1% and 22.4%, accordingly compared to those observed 1 month later after OHT. At 12 months, patients having 4GS and GScp who undergone heart transplantation was not different form the healthy individuals. Conclusion. Our data suggest that the study of myocardial deformation reveals myocardial dysfunction prior to changes registered in standard EchoCG, i.e. at early terms of its development.
INFLUENCE OF CONTROL GLYCEMIA ON PARAMETERS OF HEART RHYTHM VARIABILITY, QTAND JT-INTERVALS IN PATIENTS WITH ISCHEMIC HEART DISEASE AND TYPE 2 DIABETES
Authors: Kratnov A. E.
Published: April 2022

The aim. The study was parameters of heart rhythm variability, QT- and JT-intervals in patients with ischemic heart disease and type 2 diabetes (DM). Material and methods. 131 patients aged 3069 years with unstable angina and acute myocardial infarction has been included in research. Among observable in 101 (71.6 %) patients the DM is diagnosed. Results. It is revealed, that absence of the adequate control of glycemia in patients with DM (level of glycosylated hemoglobin more than 6.5%) resulted in decrease as parasympathetic and sympathetic influences of vegetative nervous system on the sinus node. Development of repeated coronary events in patients with DM within one year of supervision associated with reduction of mainly sympathetic influences by heart (decrease of the parameter LF and relation of spectra LF/HF) that was accompanied by infringement depolarization and repolarization of myocardium. The greatest reduction of parameter LF came to light in patients with fatal outcome within one year of supervision. Conclusion. Absence of the adequate control glycemia is accompanied by infringement of regulation of vegetative nervous system in patients with ischemic heart disease and type 2 diabetes.
RELATIONSHIP BETWEEN SALT SENSITIVITY AND MORPHO-FUNCTIONAL CONDITION OF HEART
Authors: Qasimov S. E.
Published: April 2022

The purpose of this study was a comparative assessment of pathological changes in the morpho-functional condition of the heart in groups of patients with arterial hypertension, divided by salt sensitivity.

Material and methods. 93 patients with arterial hypertension (AH) and concomitant coronary heart disease were included in the study. All patients were subjected to a salt load, after which all patients were divided into groups of salt-sensitive (SS) and nonsalt-sensitive (NSS) patients. Along with this, the patient was replicated with an echocardiographic examination of the heart to determine the functional state of the heart muscle. Patients in the SS and NSS groups were compared by heart echocardiography results.

Results. Left ventricular hypertrophy was found to be more prevalent in the group of SS patients compared to the NSS group (82.6% vs. 17.0%) and the differences between the groups were statistically significant (p<0.001). In many cases, some echocardiographic parameters, such as left ventricular posterior wall thickness and intra-ventricular thickness, were higher in patients with SS, which indicated significant early remodeling of the heart in these patients.

Conclusions. The obtained data allow us to judge about the more pronounced and early occurrence of myocardial hypertrophy in SS patients.
CLINICAL CASE OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH MICROVASCULAR ANGINA
Authors: Minyuk Yu. I. , Saliyeva E. V. , Tamoyan Z. S. , Urmanova Ju. R. , Taipova L. U. , Khasanov A. Kh.
Published: April 2022

Purpose. To describe a clinical case of coronary burden without stenosing lesions of the main branches of the coronary arteries in a patient with microvascular angina with subsequent development of myocardial infarction with the formation of ischemic hypokinesis of the anterior-apical region of the left ventricle in the absence of elevated levels of serum markers of myocardial necrosis.

Materials and methods. The study is based on a single clinical case. The object of the study is the patient in whom there were complaints of pressing pain localized behind the sternum and radiating to the left arm, accompanied by a mixed shortness of breath that occurred at rest, poorly stoped short-range nitrates and narcotic analgesics, sharp General weakness. Under primary inspection state of ailing average extent of gravity, consciousness clear, position active, skin integuments and visible mucous of clean, conventional painting. The patient was evaluated laboratory parameters, ECG, echo-cardiography (ECHO-kg), chest x-ray (OGK), coronary angiography (CAG), followed by transfer to the emergency Department of cardiology.

Results. The conducted clinical and laboratory study revealed the presence of leukocytosis in the patient with the clinic of acute coronary syndrome, without increasing cardiospecific enzymes (CFC, CFC-MB, troponin test), as well as high activity of coagulogram indicators (fibrinogen, ACTV, rfmc). When conducting radiography of OGK in direct projection-congestive lungs, a picture of chronic bronchitis in combination with left ventricular myocardial hypertrophy.

Conclusion. In the presented clinical case was described an example of development of microvascular lesions in coronary arteries in a patient with manifestation of acute coronary syndrome with severe prolonged chest pain and repolarization changes on ECG and without elevated levels of serum markers of myocardial necrosis, which probably leads to the definition of this state as fragile (or sharp) microvascular dysfunction with myocardial infarction.
The Regulated NiCu Cycles with the New 57Cu(p,γ)58Zn Reaction Rate and Its Influence on Type I X-Ray Bursts: the GS 1826–24 Clocked Burster
Authors: Lam 藍 Yi Hua 乙華 , Lu 盧 Ning 寧 , Heger Alexander , Jacobs Adam Michael , Smirnova Nadezda A. , Nieto Teresa Kurtukian , Johnston Zac , Kubono 久保 Shigeru 野茂
Published: April 2022

During the X-ray bursts of GS 1826−24, a “clocked burster”, the nuclear reaction flow that surges through the rapid-proton capture process path has to pass through the NiCu cycles before reaching the ZnGa cycles that moderate further hydrogen burning in the region above the germanium and selenium isotopes. The 57Cu(p,γ)58Zn reaction that occurs in the NiCu cycles plays an important role in influencing the burst light curves found by Cyburt et al. We deduce the 57Cu(p,γ)58Zn reaction rate based on the experimentally determined important nuclear structure information, isobaric-multiplet-mass equation, and large-scale shell-model calculations. Based on the isobaric-multiplet-mass equation, we propose a possible order of

1

1

+

- and

2

3

+

-dominant resonance states and constrain the resonance energy of the

1

2

+

state. The latter reduces the contribution of the

1

2

+

-dominant resonance state. The new reaction rate is up to a factor of 4 lower than the Forstner et al. rate recommended by JINA REACLIB v2.2 at the temperature regime sensitive to clocked bursts of GS 1826−24. Using the simulation from the one-dimensional implicit hydrodynamic code Kepler to model the thermonuclear X-ray bursts of the GS 1826−24 clocked burster, we find that the new 57Cu(p,γ)58Zn reaction rate, coupled with the latest 56Ni(p,γ)57Cu and 55Ni(p,γ)56Cu reaction rates, redistributes the reaction flow in the NiCu cycles and strongly influences the burst ash composition, whereas the 59Cu(p,α)56Ni and 59Cu(p,γ)60Zn reactions suppress the influence of the 57Cu(p,γ)58Zn reaction and diminish the impact of nuclear reaction flow that bypasses the important 56Ni waiting point induced by the 55Ni(p,γ)56Cu reaction on the burst light curve.
Impact of the New 65As(p,γ)66Se Reaction Rate on the Two-proton Sequential Capture of 64Ge, Weak GeAs Cycles, and Type I X-Ray Bursts Such as the Clocked Burster GS 1826−24
Authors: Lam 藍 Yi Hua 乙華 , Liu 刘 Zi Xin 子鑫 , Heger Alexander , Lu 盧 Ning 寧 , Jacobs Adam Michael , Johnston Zac
Published: April 2022

We reassess the 65As(p,γ)66Se reaction rates based on a set of proton thresholds of 66Se, S
p(66Se), estimated from the experimental mirror nuclear masses, theoretical mirror displacement energies, and full p
f-model space shell-model calculation. The self-consistent relativistic Hartree–Bogoliubov theory is employed to obtain the mirror displacement energies with much reduced uncertainty, and thus reducing the proton-threshold uncertainty up to 161 keV compared to the AME2020 evaluation. Using the simulation instantiated by the one-dimensional multi-zone hydrodynamic code, Kepler, which closely reproduces the observed GS 1826−24 clocked bursts, the present forward and reverse 65As(p,γ)66Se reaction rates based on a selected S
p(66Se) = 2.469 ± 0.054 MeV, and the latest 22Mg(α,p)25Al, 56Ni(p,γ)57Cu, 57Cu(p,γ)58Zn, 55Ni(p,γ)56Cu, and 64Ge(p,γ)65As reaction rates, we find that though the GeAs cycles are weakly established in the rapid-proton capture process path, the 65As(p,γ)66Se reaction still strongly characterizes the burst tail end due to the two-proton sequential capture on 64Ge, not found by the Cyburt et al. sensitivity study. The 65As(p,γ)66Se reaction influences the abundances of nuclei A = 64, 68, 72, 76, and 80 up to a factor of 1.4. The new S
p(66Se) and the inclusion of the updated 22Mg(α,p)25Al reaction rate increases the production of 12C up to a factor of 4.5, which is not observable and could be the main fuel for a superburst. The enhancement of the 12C mass fraction alleviates the discrepancy in explaining the origin of the superburst. The waiting point status of and two-proton sequential capture on 64Ge, the weak-cycle feature of GeAs at a region heavier than 64Ge, and the impact of other possible S
p(66Se) are also discussed.
Self-discharge by Streaming Cosmic Rays
Authors: Ohira Yutaka
Published: April 2022

A new nonthermal phenomenon caused by streaming cosmic rays (CRs) in the universe is proposed. The streaming CRs drive the return current of thermal electrons to compensate for the CR current. Then, electric fields are induced by the resistivity of the return current. It is shown that the resistive electric fields can accelerate secondary electrons generated by the streaming CRs. This is the self-discharge by streaming CRs. In this work, the self-discharge condition and the condition for runaway acceleration of secondary electrons are presented. The self-discharge creates high-energy secondary electrons, resulting in enhancements of ionization and nonthermal emission including the Kα emission line of neutral iron. After the self-discharge, the return current of thermal electrons is replaced by the electric current of secondary electrons. Since some generation and amplification of magnetic fields are driven by the return current of thermal electrons, the self-discharge can significantly influence them.
Coexistence of Martian Proton Aurorae and Proton Cyclotron Waves during the Enhancement of Solar Wind Activity
Authors: Yun Xiaotong , Fu Song , Ni Binbin , Xu Wei , Gu Xudong , Cao Xing , Ma Xin , Luo Qiong , Hua Man , Xiang Zheng , Du Hengle
Published: April 2022

Due to the lack of a global magnetic field, the charge exchange process between the solar wind protons and Martian hydrogen corona is of critical importance to Mars’ atmosphere. The energetic neutral atoms and pickup H+ produced during this process can further excite proton aurorae and proton cyclotron waves (PCWs) in the near-Mars space, for which the observational evidence however remains very limited. Here we report a particular event to show that the PCWs and proton aurorae were simultaneously recorded by the Mars Atmosphere and Volatile EvolutioN spacecraft during 10 consecutive orbits. As the byproducts of the charge exchange process, these two phenomena are found to be highly correlated in both space and time, with the correlation coefficient >0.7 between the auroral emissions and PCW amplitudes. Moreover, the wave and ultraviolet measurements show clearly that both the PCWs and proton aurora events tend to occur more frequently and intensively within the stream interaction region, as being strongly modulated by the solar wind activity. Our results indicate that the solar wind can directly transport energy and particles into the near-Mars environment, leading to the simultaneous enhancements of plasma wave activity and proton precipitation, which therefore helps comprehend the significant role of the solar wind activity and charge exchange process in driving the energy budget to the Martian upper atmosphere.
A Comparative Analysis to Deal with Missing Spectral Information Caused by RFI in Cosmological H i 21 cm Observations
Authors: Chakraborty Arnab , Datta Abhirup , Mazumder Aishrila
Published: April 2022

We investigate the effect of radio-frequency interference (RFI) excision in estimating the cosmological H i 21 cm power spectrum. Flagging of RFI-contaminated channels results in a nonuniform sampling of the instrumental bandpass response. Hence, the Fourier transformation of visibilities from frequency to delay domain contaminates the higher foreground-free delay modes, and separating the spectrally fluctuating H i signal from spectrally smooth foregrounds becomes challenging. We have done a comparative analysis between two algorithms, one-dimensional CLEAN and least-squares spectral analysis (LSSA), which have been used widely to solve this issue in the literature. We test these algorithms using the simulated SKA-1 Low observations in the presence of different RFI flagging scenarios. We find that, in the presence of random flagging of data, both algorithms perform well and can mitigate the foreground leakage issue. But CLEAN fails to restrict the foreground leakage in the presence of periodic and periodic plus broadband RFI flagging and gives an extra bias to the estimated power spectrum. However, LSSA can restrict the foreground leakage for these RFI flagging scenarios and gives an unbiased estimate of the H i 21 cm power spectrum. We have also applied these algorithms to observations with the upgraded GMRT and found that both CLEAN and LSSA give consistent results in the presence of realistic random flagging scenarios for this observed data set. This comparative analysis demonstrates the effectiveness and robustness of these two algorithms in estimating the H i 21 cm power spectrum from data sets affected by different RFI scenarios.