bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Malus Domestica (Apple Peel) Extract on Peripheral Blood and Bone Marrow Cells of Prednisolone Treated Mice
Authors: Iram Kamal  , Rizwan Faisal  , Lubna Amer  , Abdul Mudabbir Rehan  , Sadia Chiragh
Published: September 2023

Introduction: Apple peel is rich in many bioactive compounds and has been studied for its beneficial effects and protective role in multiple disorders, but its effect on blood cells and bone marrow needs to be investigated.

Aims & Objectives: To determine the effects of apple peel extract on peripheral blood and bone marrow cells of prednisolone treated mice.

Place and duration of study: Pharmacology Department of Post Graduate Medical Institute and Pathology Department of Fatima Jinnah Medical University, Lahore from June to September, 2016.

Material & Methods: Forty Swiss albino mice were randomized into five equal groups. Normal control group was given distilled water. Model group was given prednisolone 4 mg/kg orally. Experimental low, medium, and high dose groups were given 25 mg/kg, 50mg/kg and 100 mg/kg apple peel extract respectively along with prednisolone for 14 consecutive days by oral route. On 14th day, blood was analyzed for red blood cell, platelet, total leukocyte, and differential leukocyte count whereas, bone marrow was analyzed for erythropoiesis, megakaryocytes, myelopoiesis, lymphocyte and plasma cell count.

Results: Prednisolone treatment group exhibited significantly raised neutrophil and decreased lymphocyte percentage, whereas anon-significant rise in RBC, WBC, and platelet count was noted as compared to the normal group. Bone marrow smear megakaryocytes, myelopoiesis, lymphocytes, and cellularity: fat ratio also increased non-significantly by prednisolone treatment. Low dose of apple peel extract enhanced these effects, making significant difference, while medium and high doses negated these effects in accordance with their dose.

Conclusion: Apple peel extract in low dose complemented the effect of prednisolone on hematological parameters of mice peripheral blood and bone marrow, while high dose nullified these effects in a dose dependent manner.
Is Upper Pole Puncture for Percutaneous Nephrolithotomy (PCNL) Safe and Effective?
Authors: Irfan Sharif  , Irfan Sharif  , Athar Mahmood  , Ghulam Ghous  , Nabeel Shafi  , Humayun Saeed  , Muhammad Shahzad Anwar  , Muhammad Farooq
Published: September 2023

Introduction: During this modern era of surgery, where miniaturization has taken a front row seat, endo-urology is flourishing like never before. PCNL has become the chosen tool for treating Staghorn stones, large renal calculi and complex upper ureteric calculi. The renal collecting system can be accessed by upper or lower pole puncture. Lower pole access is considered safer with fewer complications; however the benefits of upper pole access for PCNL also stands tall due to direct access to the most of renal calyxes system, renal pelvis and upper ureter. A lot of debate and confusion is recorded worldwide with respect to both methods.
Aims & Objectives: To determine the outcome of upper pole access for removal of renal stones in patients undergoing Percutaneous Nephrolithotomy.
Place and duration of study: A descriptive study, conducted in Department of Urology, SIMS/SHL, in 2 year period i.e. 1-02-2018 to 31-01-2020.
Material & Methods: A Total of 62 patients fulfilling selection criteria were included in the study. All of these cases were operated under general anesthesia. Post-operatively, patients X-ray K.U.B were performed for presence or absence of stone. If there was no stone found in x-ray, then efficacy was labeled as high. Regarding complications, patients were evaluated for presence of hydrothorax and bleeding. If there was no complication, then safety was labeled as adequate. All this information was recorded on proforma.
Results: The mean age of patients was 32.58±9.41 years. There were 29 (46.8%) males and 33 (53.2%) females. The mean size of stone was 2.50±0.50mm. In this study, 20 (32.3%) patients had one stone, 25 (40.3%) had two stones and 17 (27.4%) had three stones. High Efficacy of PCNL was achieved in 50 (80.6%) patients while PCNL was adequately safe in 45 (72.6%) cases while 17 (27.4%) patients had complications.
Conclusion: This study showed that PCNL with upper pole approach was found to be highly effective in renal stone removal and is also safe in more than 70 % of cases.
Knowledge, Attitude, and Practice Trends Towards Covid-19 Pandemic: Comparison Between Individuals with Medical and Non-Medical Backgrounds
Authors: Mirza Zeeshan Sikandar  , Bilal Husnain Bajwa  , Hasan Zahid  , Sobia Ali  , Sabiha Iqbal  , Syed Imran Ali Shah
Published: September 2023

Introduction: Coronavirus disease 2019 (COVID-19) is a highly infectious viral disease with high morbidity and mortality. Successful control of COVID-19 requires an approach of safety and cautious behavior of the general public as well as healthcare workers which can be attained by enhancing awareness based on scientific evidence.

Aims & Objectives: To assess the knowledge, attitude, and practice (KAP) of Covid-19 safety precautions in people with a medical and allied health background and compare them with non-medical people from the local population.

Place and duration of study: Study was conducted at Central Park Medical College from July 2020 to September 2020.

Material & Methods: A total of 976 people participated in the study and were segregated into two groups; Group 1 (People having medical background; n=388) and Group 2 (People having non-medical background; n=588) to compare KAP scores between Group 1 and  Group 2 by using validated scales on Google forms. Data were presented as percentages and frequencies. Independent sample t-test was used to analyze statistical differences.

Results: Higher knowledge scores were observed for group 1 as compared to group 2 (9.92 + 2.27 v/s 9.16 +2.53; p= 0.001). Better knowledge, good attitude and safe practice trends were observed in group 1 (medical background) as compared to group 2 (non-medical background).

Conclusion: Individuals with a medical background are more knowledgeable and exhibit a cautious attitude and better safety practices regarding COVID-19 as compared to the general population. There is a need to educate the general population about safety measures for COVID-19 including social distancing, usage of masks, self-isolation, avoidance of gatherings and others.
Postpartum Intrauterine Contraceptive Device (PPIUCD) Versus Interval Intrauterine Contraceptive Device (IUCD) Complications: Which is better?
Authors: Muhammad Ikram  , Amna Javed  , Ayesha Shahid  , Sara Muneer  , Fariha Tahir
Published: September 2023

Introduction: Intrauterine Contraceptive Device (IUCD) is an effective mode of contraception. But its timing of insertion remained debateable. Studies has shown that Postpartum Intrauterine Contraceptive Device (PPIUCD) is associated with less complications as compared to interval IUCD. But controversial results have been noted. This study aims to compare intricacy & efficacy of PPIUCD Vs interval IUCD.

Aims & Objectives: To compare the complications of postpartum versus interval intrauterine device insertion (Copper T) in females seeking contraception in teaching hospital of Lahore.

Place and duration of study: The six months study was conducted in Department of Obstetrics & Gynecology, Shaikh Zayed Medical Complex, Lahore from 15-3-2018 to 15-9-2018.

Material & Methods: In this Randomized controlled trial 200 women were enrolled and divided into 2 groups. In group A, IUCD (Copper T) was implanted within 10 minutes of delivery of placenta (PPIUCD). In group B, IUCD (Copper T) was implanted after 6 weeks of delivery (Interval IUCD) and both groups were asked to follow up for 6 months and present in case of any complication. Data was analyzed using SPSS version 21.

Results: In this study, the frequency of bleeding was (Group-A: 12% & Group-B: 18%, p-value=0.235), per vaginal discharge (Group-A: 4% & Group-B: 9%, p-value=0.152), abdominal pain (Group-A: 4% & Group-B: 14%, p-value=0.013), pelvic inflammatory disease (Group-A: 5% & Group-B: 11%, p-value=0.118) and IUCD removal (Group-A: 9% & Group-B: 14%, p-value=0.268) was higher in Group-B patients. However, expulsion rate was observed to be higher in Group-A patients (8% Vs 3% in Group B).

Conclusion: Based on this study, it can be analyzed that Postpartum Intrauterine Contraceptive Device (PPIUCD) is more effective than Interval IUCD in terms of lower bleeding, PV discharge, pelvic inflammatory disease, abdominal pain and IUCD removal.
Predation of Atelocynus microtis and Speothos venaticus (Carnivora: Canidae) by Boa constrictor (Squamata: Boidae) in Southwestern Brazil and Southeastern Peru
Authors: Leite Renata , Champagne Patrick , Ferreira Evandro
Published: September 2023

Literature on the predation ecology of Amazonian canids is scarce, especially for the two rarely observed canids; Speothos venaticus (Bush Dog) and Atelocynus microtis (Short-eared Dog). Between 2000 and 2005 we documented one observation of predation of a A. microtis from southeastern Peru and an observation of S. venaticus predation from southwestern Brazil.
Pelatihan Membangun Website Portofolio Menggunakan Bootstrap V5.3 Pada Siswa/I SMK Swasta Jambi Medan
Authors: Wayahdi M. Rhifky , Ginting Subhan Hafiz Nanda , Ruziq Fahmi
Published: September 2023

Perkembangan teknologi terjadi begitu cepat, salah satunya teknologi website. Sehingga masyarakat dituntut untuk mengikuti perkembangan teknologi tersebut. Namun sebagian besar masyarakat kita masih kurang memahami atau mengerti teknologi yang menyebabkan sulit tercapainya revolusi industri 4.0. Bahkan banyak lulusan IT yang tidak memiliki kemampuan (skill) yang dibutuhkan industri saat ini. Maka dari itu Penulis melakukan pengabdian kepada masyarakat dengan target yaitu siswa/i SMK di mana peningkatan skill harus dilakukan secepat mungkin sebelum mereka memasuki dunia perkuliahan ataupun dunia kerja. Kegiatan ini adalah pelatihan membangun website portofolio menggunakan framework bootstrap v5.3 yang dimulai dari pengenalan (dasar) sampai menghasilkan produk website yang diinginkan. Hasil dari kegiatan pelatihan ini adalah peserta sangat antusias, termotivasi, dan seluruhnya berhasil membangun website portofolio seperti yang diajarkan dengan hasil yang sangat baik.
Pendampingan UMKM Alfa Shoofa Batik Kudus Melalui Pembuatan Media Sosial Untuk Meningkatkan Penjualan
Authors: Kusuma Wardani Dhias Pramudita
Published: September 2023

Pemanfaatan media sosial sebagai media promosi banyak dimanfaatkan oleh UMKM. Penggunaan media sosial untuk promosi menawarkan biaya yang murah, pengoperasian yang mudah, dan tidak harus memiliki keahlian di bidang IT sehingga dapat dijangkau pasar yang lebih luas. Setiap tahun pengguna media sosial selalu meningkat mulai dari Tiktok, instagram dan facebook. Pemanfaatan media sosial untuk promosi bertujuan meningkatkan penjualan hal tersebut melatarbelakangi kegiatan pembinaan ini dengan memaksimalkan peran media sosial untuk UMKM batik. Pengabdian ini dilakukan pada UMKM Alfa Shoofa Batik Kudus, Kecamatan Gribig, Kabupaten Kudus selama satu bulan sejak tanggal 6 Juli 2023. Permasalahan mengenai kurang optimalnya penggunaan media sosial sebagai media promosi menjadi penyelesaian utama dalam pembinaan UMKM ini. Metode yang dapat dilakukan adalah pelatihan dan pembinaan pemanfaatan media sosial untuk peningkatan penjualan pada marketplace. Hasil pengabdian menunjukkan bahwa bimbingan dan pelatihan yang dilakukan sangat bermanfaat dan mengajarkan UMKM Alfa Shoofa Batik kudus menyusun content promosi sekaligus mengarsipkan dokumen-dokumennya yang penting, terutama produk-produk batik yang dihasilkan.
Pengenalan Struktur Website, Tools, dan Karir Web Developer pada Siswa-Siswi SMK Swasta Jambi Medan
Authors: Ruziq Fahmi , Wayahdi M. Rhifky , Ginting Subhan Hafiz Nanda
Published: September 2023

Pengenalan Struktur Website, Tools, Dan Karir Web Developer merupakan sebuah kegiatan pengabdian masyarakat yang dilakukan di SMK Swasta Jambi Medan. Kegiatan ini bertujuan untuk memberikan pengetahuan dasar tentang pengembangan website kepada siswa-siswi SMK, mengenalkan alat-alat dan perangkat yang digunakan oleh Web Developer, serta membahas potensi karir dalam bidang tersebut. Metode kegiatan meliputi penyusunan rencana, pendahuluan, presentasi, demonstrasi, pembuatan portofolio, diskusi, dan evaluasi. Kegiatan ini diadakan di lokasi sekolah dengan melibatkan 20 siswa sebagai peserta. Hasil dan pembahasan menunjukkan bahwa kegiatan ini memberikan dampak positif bagi peserta. Mereka mendapatkan pemahaman dasar tentang struktur website dan alat yang digunakan dalam pengembangan web. Motivasi untuk belajar lebih lanjut di bidang web development juga meningkat, dan pelatihan ini memberikan panduan awal untuk membangun website sederhana. Siswa merasa lebih siap untuk memasuki dunia kerja yang teknologis dengan potensi karir sebagai Web Developer atau Web Designer. Kegiatan ini membantu mereka dalam mempersiapkan diri untuk masa depan yang lebih terhubung dengan teknologi.
The Effect of Light Intensity and Nutrient Formula on the Growth of Chlorella ellipsoidea in Batch Cultivation
Authors: Theerapisit Sudarat , Rodjaroen Somrak , Sintupachee Siriluk
Published: September 2023

In the aquaculture feed industry, the batch cultivation of the alga Chlorella ellipsoidea is frequent because it allows the control of factors contributing to product quality. In this study, we conducted batch-cultivation experiments in a smart algae cabinet with 4 different light intensities, 1,000, 3,000 and 5,000 Lux, as well as a fluorescent lamp (8,000 Lux). The growth curves, specific growth rate and biomass productivity of C. ellipsoidea provided with the BG-11, Bold and Chu-13 nutrient formulae were evaluated. The results revealed biomasses of 1.315 ± 0.0087, 1.042 ± 0.0063 and 1.096 ± 0.0036 g/L/day and specific growth rates of 0.979 ± 0.0067, 0.7453 ± 0.0060 and 0.7781 ± 0.0026 per day for the 3 formulae, BG-11, Bold and Chu-13, respectively. The mean biomasses of C. ellipsoidea grown on BG-11 at all light intensities were significantly higher than those for other media (p-value = 0.0001). With the log phase achieved in 3 days, BG-11 was more suitable for rearing at all tested light intensities, while Chu-13 was only applicable at 5,000 Lux. Using all 3 light intensities, it was possible to reduce the log-phase of algae growth from 7 to 3 days and increase biomass by more than 1.2 times when compared to fluorescent light culture.
HIGHLIGHTS

The batch cultivation was carried out in a smart algae cabinet that we are building and will publish soon.
A smart algae network can control the factors that affect cultivation while also conducting all experiments at the same time.
The 3 light intensities and BG-11 media used for cultivation in a smart algae cabinet can accelerate growth and biomass production.

GRAPHICAL ABSTRACT
Impact of Promotion Over the Marketing of New Products
Authors: Dr. Amardeep Bajpai
Published: September 2023

Marketing of trade comprising conveying services needs that the businesses create their vital resolution. This verdict distresses the entire publicising databases of the industry, humbly putting the advertising approach. These limited contributions are not individual excessive purchaser appointment approach, however, they similarly support in what pattern the business value the customer and appointment and devotion are indispensable for some fruitful development marketing approach. Promotion is a vigorous element of existence and expansion, deprived of acceptable promotion harvests may not vend, while they their stability is in hesitation. The marketing promotion encompasses publicity individual vending sales elevation, community relatives and straight advertising is frequently related with allure and ostentation.
Primary quantitative method has been used and primary source of data has been gathered for authentication of this research from the surveys of 55 people. Approximately clear demonstrations and illustrations have been acknowledged in this portion for recovering the gratitude and thoughtful of this context.IBM SPSS tool has been used for the data analysis and it was created through the significant value, descriptive statistics and regression table. The promotion of the new launching products and its impact on the business marketing and the pattern of this impact have been evaluated there. The collected data has been established by the dependent and independent variables
Encyclopedia of Contemporary Christian Fiction
Authors: Tischler Nancy M.
Published: September 2023

A biographical encyclopedia of American and British Christian-themed writers from World War II to the present, covering acclaimed literary works and popular evangelical fiction.

Encyclopedia of Contemporary Christian Fiction offers 90 alphabetically organized entries covering the field�s most important writers. Each entry includes a brief biography, religious and educational background, a survey of major works and themes, and a summary of critical response, as well as a bibliography of major works and criticism.
Principal Strategic Management in Enhancing Teacher Professionalisme at MAN 3 Langkat
Authors: Syahputra Muhammad Riski , Siregar Mhd. Fuad Zaini , Nadila Yuria
Published: September 2023

Education is a conscious and planned effort aimed at creating a conducive learning environment and processes for students to actively develop their potential, encompassing spiritual strength, self-control, personality, intelligence, noble character, and essential skills for themselves, society, the nation, and the state. This research explores the strategic management of school principals in enhancing teacher professionalism at MAN 3 Langkat. The qualitative research method, employing a phenomenological approach, is chosen to deeply understand natural phenomena related to school principal strategies in improving teacher professionalism. The findings reveal several strategies used by the school principal, such as intensifying meetings, effective teacher duty rotation, sending teachers to workshops, and offering guidance and supervision. The school principal's enthusiasm for improving teacher professionalism is evident through professional training and active involvement in problem-solving. In conclusion, the school principal's strategic management significantly contributes to enhancing teacher professionalism at MAN 3 Langkat. This research underscores the importance of collaboration between school principals and teachers, sharing a common vision, mission, and goal in achieving educational objectives. It emphasizes the continuous professional development of teachers to optimize their potential and deliver high-quality education.
Development of Comic Media for Children's Stories Material Characteristics of Poetry in Indonesian Subjects to Increase Students' Interest in Reading
Authors: Nuradilah Nuradilah , Fitriyani Fitriyani
Published: September 2023

This research is motivated by the limited teaching materials in elementary schools and the lack of development of learning media that can attract students' interest in reading. This development research aims to produce children's story comic products, namely KOMPISA (Indonesian Smart Comics) and find out the practicality and effectiveness of students towards Children's Story Comics in Indonesian Language Subjects in class IV, so that the quality of learning at school is much more enjoyable and is better able to hone their skills. students in increasing interest in reading.. The results of this study, produce Children's Story Comics that can be used at the elementary school level as teaching materials for students who have met the very good criteria with an average score of the three experts, namely 96.9% in the very category. feasible to use, and the practicality level of 87.9% is in the very practical criteria and the level of effectiveness with an average of 90% is in the very effective category. The teaching materials for children's story comics are appropriate, practical and effective for use in learning Indonesian, material for the characteristics of poetry for grade IV elementary schools.
Treatment with biological products for chronic rhinosinusitis with nasal polyp
Authors: Han Seung Cheol , Cha Hyunkyung , Kim Dong-Young
Published: September 2023

Background: Chronic rhinosinusitis (CRS) is further classified as CRS with nasal polyp and CRS without nasal polyp. It is also divided into type 2 and none-type 2 by immunological endotype. Nowadays, novel biological products targeting type 2 inflammation are developed and used for the treatment of CRS with nasal polyp.Current Concepts: Dupilumab, which inhibits interleukin-4 and interleukin-13, and omalizumab, which targets immunoglobulin E, were recently approved and are currently being used as the treatment regimen for patients with recurrent CRS with nasal polyp in Korea. Many studies demonstrated enough effects of both biological products on nasal symptoms, including smell, quality of life, and polyp size. The indication of biological products is refractory CRS with nasal polyp with severe symptoms even after endoscopic sinus surgery. However, the main drawback of these biological products is a high cost since they are non-reimbursement regimens as defined by Korean national health insurance.Discussion and Conclusion: Further research on the use of dupilumab and omalizumab in Korean patients will be needed because the Korean CRS endotype, which is characterized by less-type-2 CRS, is different from Western CRS endotypes. Additionally, investigations on the comparison of efficacy among various biological products are essential to prescribe the most appropriate biological products depending on the patients’ endotypes.
Treatment with biological products for chronic urticaria
Authors: Ye Young-Min
Published: September 2023

Background: Chronic urticaria is characterized by repeatedly occurring itchy wheals and/or angioedema for at least six weeks. The prevalence of chronic urticaria is increasing globally, with variations observed among different regions. Chronic urticaria has a long duration and may recur over time. Effective and tolerable treatment for such patients is crucial due to unpredictable, recurrent, and disabling symptoms, as well as the significant impact on quality of life.Current Concepts: Recent guidelines recommend the regular use of non-sedative second generation antihistamines as the first line of treatment for chronic urticaria. For patients whose urticarial symptoms persist or worsen with the approved dose of antihistamines, the guideline recommends the second line of treatment, which involves either increasing the dosage of the initial antihistamine or combining it with three other kinds of antihistamines. However, almost half of patients with chronic urticaria are refractory to antihistamines. Recently, treatment modulating immunoglobulin E (IgE) levels and activities was found to provide an efficient therapeutic approach. Omalizumab, the only approved anti-IgE treatment to date for patients with chronic urticaria, has demonstrated strong evidence of both efficacy and safety. Recent international guidelines recommend omalizumab as the first choice of treatment for antihistamine-refractory chronic spontaneous urticaria.Discussion and Conclusion: As omalizumab is not a curative and disease-modifying agent, there is a subpopulation of patients with chronic spontaneous urticaria who partly or have never responded to omalizumab. To address this, ongoing research is exploring the therapeutic potential of other biological products that target various aspects, such as type 2 inflammation, complement system, and the c-kit pathway.
Effectiveness of swallowing therapy and forced expiratory technique to prevent aspiration for dysphagia in frail elders
Authors: Nathan C.V. Senthil , Lakshmi J. Kavitha , G. Vaishnavi , Abraham M. Manoj
Published: September 2023

Introduction and Aim: Difficulty or trouble in eating is termed to beDysphagia, which indicates experience of food encountering delays or obstructions as it moves to the stomach from the mouth. Elderly population is prone to develop dysphagia because of various illnesses that affect their swallowing function, thereby raising the threat of aspiration. The primary goal of the current learning is to  assess the effectiveness of swallowing therapy and the forced expiratory technique as preventive measures against aspiration in frail elderly individuals with dysphagia.
 
Methodology: This study is an experimental study done at ACS Medical College and Hospital, specifically in the Physiotherapy OP department. The study involved a sample of 20 individuals and had a treatment duration of 6 weeks. The participants were elderly individuals ranging from 65 to 85 years of age, comprising both males and females. Participants who scored above 18 in the mini mental state exam and fall within levels 3 to 6 according to the FIOS classification were included The outcome measures used in the study were the functional intake oral scale and the gugging swallowing screen.
 
Results: Comparing the Functional Intake Oral Scale (FIOS) Score between the Pre-test and Post-test mean values of 4.40 and 6.40 (Swallowing Therapy) reveals a significantly significant difference between the two mean values at P 0.001. Comparing the gugging swallowing screen (GUSS)score between the Pre-test and Post-test mean values of 11.30 and 17.60 (Swallowing Therapy), it is very significant that there is a difference between the Pre-test and Post-test mean values at P 0.001.
 
Conclusion: It is concluded that there is significant improvement in effects of swallowing therapy for dysphagia in frail elders and forced expiratory technique to prevent aspiration.
In silico molecular docking studies of drugs Donepezil and Galantamine towards SARS-CoV-2 main protease (Mpro)
Authors: A. Sumitha , Brindha Devi Parthiban , Subramanian Vidhya , B. Geetha , G. Vaishnavi
Published: September 2023

Introduction and Aim:  COVID-19(Corona viral disease) has caused morbidity and mortality across the globe. In spite of some repurposed drugs and vaccines, researchers are in search of effective treatment against SARS-CoV-2 infection. Donepezil and Galantamine are acetylcholinesterase inhibitor drugs with pharmacological benefit in Alzheimer’s therapy. An effort has been made in this study for in silico evaluation of drugs Donepezil and Galantamine for its antiviral activity against Coronavirus.
 
Materials and Methods: Molecular docking studies of ligands Donepezil and Galantamine were executed by using corona viral Protease (Mpro) protein as a target. Docking study was performed using Autodock 4.2.6 software. The activity of ligands depends on hydrogen bond interactions with active sites of protein of Mpro protein and docking score.
 
Results: Docking studies reveal that the compound Donepezil is well interacted with nonpolar amino acids. The Galantamine molecule has good affinity towards the protein and reveals the docking score of -7.3 kcal/mol. The tight binding of ligands Donepezil and Galantamine to the protein of MPro will stop further replication and transcription of viral proteins.
 
Conclusion: Ligands Donepezil and Galantamine are well engaged with the active site of the main protease (M Pro) of SARS-CoV-2. These compounds can help in novel drug identification towards Covid-19.
Detection of differentially expressed circulating micro-RNA among Indians with Type 2 Diabetes using a global expression profile and systematic analysis
Authors: Sambashivaiah Sucharita , Priyanka Ashwini , Nimbalkar Vidya , V. P. Snijesh , Prabhu Jyothi
Published: September 2023

Introduction and Aim: In recent years research on molecular mechanisms leading to Type 2 Diabetes Mellitus (T2DM) has discovered the promising role of microRNA (miRNA) as an early biomarker for the diagnosis of the clinical state. However, there is a lack of data from the Indian population exploring the global expression of circulating miRNA using precise and sensitive methods. The aim was to identify and quantify the circulating miRNAs from biological samples of T2DM and healthy controls using the Nanostring nCounter Platform.
 
Material and Methods: The miRNA analysis was performed using the NanoString nCounter platform. The T2DM patients within a duration of 5 to 15 years without any complications were recruited. The healthy controls were identified without any chronic diseases. The NanoString nCounter platform probes were used to detect the newly discovered miRNAs in the chosen panel of nearly 800 miRNAs.
 
Results: Our analysis has identified many unique miRNAs that are not reported earlier such as miR -25-3p, miR451a, miR365a, miR-129-2, miR-1271, miR572, and others.
 
Conclusion: Identification of differential patterns of circulating miRNAs could offer optimistic chances for managing T2DM diagnostically and prognostically. The specific expansion of the miRNAs to know the intercommunication among miRNAs and other genes involved in the development of T2DM must be further explored to uncover the potential role in clinical practice.
Predictive value of insulin marker before and after recovery of Grave’s disease patients
Authors: Salih Ali Abeer , Hazim Hamoode Rana , A. Khalaf Zena , Abdullah Lafttah Al-Rubaii Bahaa
Published: September 2023

Introduction and Aim: Grave’s disease is a disease of the thyroid glands. Early diagnosis of hyperthyroidism can improve treatment and control. This study examined hyperthyroidism-related insulin hormone alterations before and after radioactive iodine 131 treatment. This study also examined how the medical condition affected these indicators.
 
Materials and Methods: The participants in this study included 50 people who were diagnosed with Grave’s disease, as well as 23 healthy individuals as controls. Direct inquiry was used as the technique for gathering demographic information from the patients who participated in the study. The thyroid stimulating and insulin hormonal levels of each patient were recorded before and after undergoing a hypothyroidism treatment regimen of three months that consisted of a dose of radioactive iodine 131 ranging from 10 to 20 mci.
 
Results: This research indicated a significant relation to exist between age and insulin levels among patients diagnosed with Grave’s disease. In addition, the research also demonstrated a significant association between levels of thyroid-stimulating hormone (TSH) and insulin hormones in patients both before and after radiation therapy.
 
Conclusion: Insulin hormonal levels could be used as a predictor of the severity of hyperthyroidism.
Patterns of clinical and biochemical studies on elderly patients with anemia in the southern regions of Kyrgyzstan
Authors: Mamatova Sabirakhan , Karabekova Nazgul , Madraimova Venera , Tazhibaeva Umutai , Akmaral Taalaibek kyzy , Arstanbekova Mira , Mamatov Sagynali , Imanalieva Farida
Published: September 2023

Introduction and Aim: Most studies indicate that between 10% and 45% of older people have anemia. The etiology is diverse and usually complicated. The aim of this study is to evaluate the clinical and hematological models of anemia in elderly residents of nursing homes in Kyrgyzstan's southern regions who are 60 years of age and older.
 
Materials and Methods: A total of 223 elderly persons, including 97 (43.5%) men and 126 (56.5%) women, participated in this study at nursing facilities in the southern areas of Kyrgyzstan. The elderly persons were 77.95.18 years old on average.
 
Results: 23.3% of the 223 older people in the study living in wards of nursing facilities in the southern areas of Kyrgyzstan were anemic. Iron deficiency anemia (IDA) (50%) was the most prevalent type of anemia, followed by vitamin B12 deficiency anemia (26.7%), and anemia of chronic disease (23.1%). Both blood ferritin and serum iron levels were considerably below normal, which is common for IDA. The value of vitamin B12 in the blood, which was within the usual limits (461.0–5.73 ng/l), was also revealed, indicating IDA.
 
Conclusion: Anemia affects quality of life and increases morbidity and mortality in elderly people.
Geografias emocionais de raça e patrimônio: percorrendo paisagens museais Ouro-Pretanas
Authors: Sousa Patrício Pereira Alves de
Published: September 2023

Este artigo discute a forma como as identidades negras são representadas e imaginadas em três museus da cidade de Ouro Preto-MG. O instrumento utilizado para a pesquisa foi a etnografia dos percursos, metodologia que permitiu analisar as imagens e histórias que se encontram sobrepostas nas paisagens internas dos museus e considerar suas exposições como elementos vivos e pulsantes produtores de sensibilidades. Dessa forma, a argumentação problematiza a maneira como os espaços de memória ouro-pretanos participam da construção de geografias emocionais sobre a negritude de modo a criar sensações como sofrimento, dor, aversão e repulsa. Indicações são ainda realizadas a respeito de como as paisagens racializadas atuam na construção de impressões sobre a realidade social e de como suas composições estão abertas à reelaborações.
Pengaruh Job Insecurity dan Beban Kerja terhadap Turnover Intention (Studi Kasus pada Karyawan Milenial dan Gen Z di Bank BJB Cabang Daan Mogot)
Authors: Priyono Agung , Tampubolon Sunny
Published: September 2023

Bonus demografi yang nantinya akan dihadapi Indonesia akan menjadikan penduduk yang berusia produktif sebagai pengerak dalam suatu organisasi. Usia produktif banyak ditemui pada generasi milenial dan gen Z yang memiliki kecenderungan gaya hidup yang berubah-ubah dan ingin mencoba hal baru karena memiliki kepribadian yang merasa tidak puas. Karakteristik ini mengakibatkan mereka berkeinginan pindah-pindah kerja dari perusahaan sekarang ke perusahaan baru yang disebut turnover intention. Mudahnya berpindah-pindah bekerja dapat dikarenakan ketidakamanan bekerja (job insecurity) dan beban kerja yang ditanggung selama melakukan pekerjaan. Penelitian ini memiliki tujuan menguji dan menganalisis pengaruh job insecurity dan beban kerja terhadap turnover intention. Sampel penelitian berjumlah 83 responden dan menggunakan teknik purposive sampling. Kriteria responden yang ditetapkan adalah karyawan generasi milenial dan gen Z Bank BJB cabang Daan Mogot. Analisis data menggunakan SEM-PLS yang kemudian diolah dengan program SmartPLS 3.0. Hasil pada penelitian yang diuji menunjukkan terdapat pengaruh positif signifikan job insecurity terhadap turnover intention. Beban kerja juga memiliki pengaruh positif signifikan terhadap turnover intention.
Pengaruh Green Innovation Dan Green Organizational Culture Terhadap Company Performance Melalui Green Competitive Advantage (Studi Kasus Pada Gerai Kopi XYZ)
Authors: Sugiharto Rudy , Alhazami Lutfi
Published: September 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Green Innovation dan Green Organizational Culture terhadap Company Performance melalui Green Competitive Advantage pada gerai kopi XYZ di Jakarta Barat. Penelitian ini dilakukan dengan menggunakan pendekatan kuantitatif dengan jumlah sampel 68 responden. Instrumen yang digunakan peneliti adalah kuesioner. Pengujian instrumen meliputi uji validitas dan uji reliabilitas dengan menggunakan alat analisis SPSS versi 23. Analisis data menggunakan analisis deskriptif, sedangkan untuk pengujian hipotesis menggunakan analisis jalur (path analysis). Hasil penelitian menunjukan bahwa Green Innovation dan Green Organizational Culture berpengaruh signifikan terhadap Green Competitive Advantage, Green Innovation dan Green Organizational Culture berpengaruh signifikan terhadap Company Performance melalui Green Competitive dan Green Competitive Advantage berpengaruh signifikan terhadap Company Performance.
Konsekuensi Hukum Putusan Hakim di Bawah Batas Minimum pada Perkara Pidana Narkotika
Authors: Arifyansyah Arifyansyah
Published: September 2023

Pemerintah telah mengesahkan Undang-Undang No. 35 Tahun 2009 tentang Narkotika yang diharapkan mampu sebagai faktor penangkal terhadap merebaknya pelaku penyalahgunaan narkotika. Penelitian ini bertujuan untuk menganalisa konsekuensi hukum putusan hakim di bawah batas minimum pada perkara pidana narkotika. Penelitian ini menggunakan metode pendekatan yuridis normatif. Pendekatan yuridis digunakan untuk menganalisis berbagai asas dan teori yang berkaitan dengan permasalahan yang diteliti. Hasil Penelitian menunjukkan bahwa hakim yang mentapkan putusan di bawah batas minimum memberikan konsekuensi hukum yang bertentangan dengan asas legalitas jika didasarkan pada penasiran peraturan perundang-undangan yang telah ada yang melahirkan penemuan hukum oleh hakim menyebabkan tidak adanya kepastian hukum.
Zanubrutinib (Brukinsa)
Authors: CADTH
Published: September 2023

CADTH recommends that Brukinsa be reimbursed by public drug plans for the treatment of adult patients with chronic lymphocytic leukemia (CLL) if certain conditions are met.

Brukinsa should only be covered to treat adult patients with previously untreated CLL for whom fludarabine-based treatment is inappropriate or patients with relapsed or refractory (r/r) CLL who have received at least 1 prior systemic therapy. Patients receiving Brukinsa should be in relatively good health (i.e., have a good performance status, as determined by a specialist). Patients who have progressed on a Bruton tyrosine kinase (BTK) inhibitor or patients with prolymphocytic leukemia or Richter’s transformation should not be eligible for coverage.

Brukinsa should only be reimbursed if prescribed by clinicians with expertise and experience in the treatment of CLL and monitoring of therapy and if it is associated with cost savings for drug programs relative to ibrutinib or acalabrutinib. Patients who experience disease progression while taking Brukinsa or who cannot tolerate the drug would not be eligible for continued coverage.
Hubungan Karakteristik dengan Kepatuhan Minum Obat Antidiabetes Pasien Diabetes Melitus di Pelayanan Kesehatan Kota Cirebon
Authors: Efriani Like
Published: September 2023

Karakteristik pasien dan tingkat kepatuhan merupakan komponen dari pasien yang diperlukan untuk mencapai keberhasilan terapi pengobatan diabetes melitus (DM). Pengobatan DM merupakan penyakit yang memerlukan tingkat kepatuhan agar tercapai tujuan pengendalian kadar glukosa darah pada pasien. Ketidakpatuhan minum obat antidiabetes menyebabkan kadar glukosa darah dalam tubuh menjadi tidak terkontrol. Penelitian ini bertujuan untuk melihat adanya hubungan antara karakteristik pasien DM dengan kepatuhan minum obat di Pelayanan Kesehatan Kota Cirebon. Penelitian dilakukan dengan pengambilan sampel secara purposive sampling dengan pendekatan cross sectional serta menggunakan lembar data demografi untuk mengetahui karakteristik pasien dan kuesioner MMAS-8 (Moriskly Medication Adherence Scale 8) untuk kepatuhan minum obat. Responden dipilih berdasarkan kriteria inklusi dan eksklusi. Hasil yang didapatkan dari responden menunjukkan karakteristik responden berdasarkan usia memiliki persentase paling banyak ada pada kategori lansia awal (46-55 tahun), diikuti dengan jenis kelamin perempuan, dan tingkat pendidikan sekolah dasar (SD). Hasil analisis hubungan menunjukkan tidak adanya hubungan yang bermakna antara karakterisik berdasarkan usia dengan kepatuhan minum obat, namun pada kategori jenis kelamin dan tingkat pendidikan memiliki hubungan yang bermakna dengan kepatuhan minum obat antidiabetes pasien DM di Kota Cirebon.
Evaluasi Pengelolaan Obat di Puskesmas Terminal Kota Banjarmasin Tahun 2021
Authors: Sariah Sariah , Fernanda Yodi , Annisa Rahmi , Wathan Nashrul
Published: September 2023

Pengelolaan obat di Puskesmas merupakan salah satu indikator mutu pelayanan kefarmasian yang penting karena menentukan keberhasilan manajemen Puskesmas. Kegiatan pengelolaan obat di Puskesmas menyangkut aspek perencanaan, permintaan, penerimaan, penyimpanan, pendistribusian, pemusnahan, pengendalian, serta pencatatan dan pelaporan. Kegiatan ini betujuan agar obat dapat dikelola secara optimal untuk menjamin ketepatan jumlah dan jenis pembekalan farmasi dalam upaya mencapai tujuan yang ditetapkan diberbagai tingkat unit kerja. Penelitian ini bertujuan untuk mengevaluasi pengelolaan obat di Puskesmas Terminal Kota Banjarmasin. Parameter yang digunakan yaitu Ketepatan Perencanaan Obat, Kesesuaian Item Obat yang Tersedia Dengan DOEN 2021, Persentase Obat yang Tidak Diresepkan Selama 6 Bulan, dan Persentase Obat Kadaluwarsa atau Rusak. Penelitian merupakan penelitian non eksperimental bersifat deskriptif yang dilakukan secara kualitatif menggunakan data retrospektif yaitu RKO dan LPLPO dari periode Januari – Desember 2021. Hasil penelitian menunjukkan evaluasi pengelolaan obat di Puskesmas Terminal Kota Banjarmasin yaitu: ketepatan perencanaan obat (68%), kesesuaian item obat yang tersedia dengan DOEN 2021 (54%), obat yang tidak diresepkan selama 6 bulan (18%) dan obat yang kadaluwarsa atau rusak (4%). Berdasarkan hasil tersebut dapat diketahui bahwa sistem pengelolaan obat di Puskesmas Terminal Kota Banjarmasin belum memenuhi standar yang telah ditetapkan.
Studi Literatur Analisis Boraks pada Bakso yang Beredar di Pasar Tradisional Indonesia Menggunakan Berbagai Metode
Authors: Habibah Siti Nur , Lestari Yulianita Pratiwi Indah , Mi’rajunnisa Mi’rajunnisa
Published: September 2023

Borax is a chemical compound that contains the element Boron (B). The purpose of this study is to determine whether meatballs circulating in various markets in Indonesia contain borax, in what levels, and how to compare the results of the analysis with various methods based on a literature study. The design of this research is to use a literature study method which is done by studying journals about tracing borax analysis journals on meatballs using various methods. The quantitative test used alkalimetric titration test, UV-Vis spectrophotometry, and Visible spectrophotometry. The results of the organoleptic test on meatballs containing borax were pale white in color, smelled like meatballs in general but had a slight chemical smell, and tasted chewy. The flame test of 3 positive studies contained borax in the presence of a green color from the flame. Tumeric paper test from 2 positive studies contained borax with a color change on the tumeric paper from yellow to brownish red. Alkalimetric titration test from 2 positive studies contained borax with a color change at the end of the titration to pink with levels of 3.82 ppm and 0.06-5.15%. Tests with UV-Vis spectrophotometry obtained results with a wavelength of 555 nm with a linearity that is R=0.9995 and an accuracy of 96.09%-104.62%, with the highest level of 2414,375 g/mL and the lowest 129,375 g/mL. Visible spectrophotometry test obtained results with a wavelength of 620 nm, namely the meatballs before being burned with a value of 0.54 ppm.
Evaluasi Manajemen Pengelolaan Obat pada Tahap Penyimpanan dan Penggunaan Obat di Apotek Rumah Sakit x
Authors: Akbar Depy Oktapian , Ramadhani Syahrizal , Herniyati Novie
Published: September 2023

Tersedianya obat ketika diperlukan dalam jumlah yang cukup dan mutu terjamin untuk mendukung pelayanan yang berkualitas di Rumah Sakit merupakan tujuan manajemen obat. Penyimpanan, dan penggunaan obat merupakan faktor penting dalam pengelolaan obat, jika pengelolaan tersebut tidak dikelola dengan baik akan memberikan dampak negatif baik secara medis, ekonomis maupun sosial. Tujuan dari penelitian untuk mengevaluasi manajemen pengelolaan obat pada tahap penyimpanan dan penggunaan obat di Apotek Rumah Sakit X dibandingkan dengan nilai indikator standar. Penelitian bersifat deskriptif dan evaluatif dengan metode observasi menggunakan data retrospektif dan concurrent. Jumlah sampel yang diambil dalam penelitian ini yaitu jumlah resep sebanyak 100 resep dan sampel obat sebanyak 231 obat dengan teknik proportional sampling. Data dianalisis denagan menggunakan indikator standar yang telah ditetapkan dengan cara membuat tabel frekuensi dan persentase. Hasil penelitian yang tidak sesuai standar pada tahap penyimpanan adalah stok mati obat (3,89%), obat kadaluarsa/rusak (2,17%), kecocokan antara fisik obat dengan kartu stok (57,14%). Pada tahap penggunaan obat adalah jumlah tiap item obat perlembar resep (2,62), obat yang dapat diserahkan 95,80%, dan persentase obat yang diresepkan sesuai formularium 76,34%.
NUTRIÇÃO E BIOMARCADORES DE ENDOMETRIOSE: POSSÍVEIS IMPLICAÇÕES CLÍNICAS
Authors: Heringer Paulina Nunes , Castelpoggi Juliana Pandini , Santana Christiany Froklich , Araújo Carla Maví de , Araújo Maria Micaelly de Melo , Pinto Rosangela Borges Santana , Mendes Natalia de Abreu , Silva Camila Camargo da , Monteiro Maria Alzirene Rodrigues , Souza Ester Vinhote de , Dantas Jessica Lopes , Cruz Danielle Benevinuto
Published: September 2023

A endometriose é uma doença crônica que afeta um grande número de mulheres em idade reprodutiva, caracterizada pelo crescimento anormal do tecido endometrial fora da cavidade uterina. Além do desconforto físico e dos sintomas incapacitantes, a endometriose também está associada a diversos problemas de saúde, incluindo infertilidade e maior risco de doenças cardiovasculares. A nutrição desempenha um papel crucial na saúde do sistema reprodutivo feminino, e estudos recentes têm investigado a relação entre a alimentação e o desenvolvimento, progressão e manejo da endometriose. Além disso, a identificação de biomarcadores de endometriose tem se mostrado uma estratégia promissora para o diagnóstico precoce e o monitoramento da doença.Nesse contexto, este artigo científico busca explorar a relação entre a nutrição e os biomarcadores de endometriose, destacando suas possíveis implicações clínicas. O objetivo principal é compreender como os componentes da dieta podem influenciar a expressão de biomarcadores da endometriose, bem como investigar a relevância desses biomarcadores como ferramentas diagnósticas e prognósticas. Para isso, será realizada uma revisão sistemática da literatura, buscando artigos relevantes publicados nos últimos 10 anos. Serão incluídos estudos clínicos, experimentais e epidemiológicos, que abordem a relação entre a nutrição e os biomarcadores de endometriose. Serão avaliados diferentes aspectos da dieta, como a ingestão de gorduras, carboidratos, proteínas, vitaminas, minerais e antioxidantes. Além disso, serão analisados diferentes biomarcadores utilizados no estudo da endometriose, incluindo marcadores inflamatórios, marcadores de estresse oxidativo, biomarcadores hormonais e marcadores de disfunção imunológica. Será dada ênfase às implicações clínicas desses biomarcadores, relacionando-os com a progressão da doença, o desenvolvimento de complicações e a resposta ao tratamento.Espera-se que os resultados deste estudo contribuam para ampliar o conhecimento sobre a relação entre nutrição e biomarcadores de endometriose, fornecendo subsídios para o desenvolvimento de estratégias de prevenção, diagnóstico e tratamento mais eficazes. Além disso, pretende-se identificar lacunas na literatura científica, que possam guiar futuras pesquisas e intervenções clínicas nessa área. Dessa forma, espera-se que este artigo possa contribuir para a melhoria da qualidade de vida das mulheres afetadas pela endometriose.
A comprehensive design schedule for electrosprayed thin films with different surface morphologies
Authors: Karuga Susan W. , Marijnissen Jan C. M. , Kelder Erik M.
Published: September 2023

Abstract. Electrospraying, a technique where a liquid jet breaks up into droplets under the influence of electrical forces, is outstanding because of its high deposition efficiency and ability to achieve thin films of different surface morphologies. Nowadays, the technique is applied in the deposition of thin films for nanoelectronics in Li-ion batteries, fuel cells and solar cells where performance of the deposited layers is determined by their morphologies. In this study, a literature survey has been conducted from which a comprehensive design schedule for electrosprayed thin films has been developed. In summary different porous and dense morphologies can be produced from the developed design schedule. Electrospray experiments have also been performed by altering different parameters as per the developed schedule. Using lithium salt precursor solutions, different thin films have been deposited on aluminium foil substrates and their characterization performed using scanning electron microscopy. The surface morphologies of the prepared thin films agree with the predictions of the developed design schedule.