bluuebunny/crossref_metadata_2025 huggingface dataset:
Ascites as a subject of studies in ovarian cancer
Authors: Villert A. B. , Kolomiets L. A. , Yunusova N. V. , Ivanova A. A.
Published: March 2019

Ovarian cancer is a highly heterogeneous disease characterized by multiple histological subtypes. High- grade serous ovarian carcinoma is the most common histological subtype of ovarian cancer. The majority of ovarian cancer patients present with malignant ascites at diagnosis. Peritoneal dissemination is one of the most unfavorable factors for tumor progression and recurrence. A more precise visualization of peritoneal carcinomatosis can be achieved by transabdominal ultrasound. However, the prognostic factors associated with malignant ascites in ovarian cancer are currently not well understood. Among the clinical parameters, the volume of ascites has the greatest information in terms of prognosis of disseminated ovarian cancer. Ovarian cancer with small-volume ascites has a more favorable therapeutic prognosis. Ascites is an easily accessible and valuable source of cellular and extracellular components contained in it that are involved in ovarian carcinogenesis. Ascites represents an accessible and valuable source of material to identify signals that influence tumor growth. At present, among the soluble high- and low molecular components of ascites, an active search for additional prognostic and predictor factors is being conducted, providing insights into the molecular mechanisms for clinical phenotypes of ovarian cancer.
mRNA expression of chemosensitivity genes as a predictor of response to neoadjuvant chemotherapy in non-small cell lung cancer
Authors: Tsyganov M. M. , Deryusheva I. V. , Rodionov E. O. , Efteev L. A. , Miller S. V. , Ibragimova M. K. , Perminova E. E. , Cheremisina O. V. , Frolova I. G. , Tuzikov S. A. , Litviakov N. V.
Published: March 2019

The objective response rate to neoadjuvant chemotherapy (NAC) in patients with non-small cell lung cancer (NSCLC) is approximately 16 %. Therefore, the search for new predictive factors and markers that could precisely predict the NAC response and be relevant to the choice of the adequate treatment policy is of utmost importance. the purpose of the study was to analyze the relationship between the expression levels of chemosensitivity genes and NAC response in patients with non-small cell lung cancer. material and methods. The study included 30 patients with stage IIAIIIB NSCLC. Total RNA was isolated from normal and tumor lung tissue samples prior to NAC. The expression level of chemosensitivity genes, such as BRCA1, RRM1, ERCC1, TOP1, TOP2a, TUBB3, TYMS, and GSTP1 was evaluated by real-time reverse transcriptase quantitative PCR (RT-qPCR). results. A significant difference in the expression levels of the studied genes between patients with different NAC response was found. The objective response to therapy was observed in 67 % (10/15) of patients having no ERCC1 expression compared to those with ERCC1 expression (p<0.05). Low (less than 0.2) and high (more than 1.2) BRCA1 expression levels were associated with low rates of NAC response compared with patients whose expression level was between the lower and upper quartiles. Statistically significant differences were shown for the GSTP1 and RRM1 genes. conclusion. A comprehensive assessment of the expression of chemosensitivity genes is important not only in terms of understanding heterogeneity and complexity of the molecular biology of NSCLC, but also for more accurate prediction of response to NAC and identification of potential drug targets.
Ability of protein epitope-containing constructs associated with melanoma to stimulate the cytotoxic activity of peripheral blood mononuclear cells against melanoma cells
Authors: Borobova E. A. , Antonets D. V. , Starostina E. V. , Karpenko L. I. , Zheravin A. A. , Ilyichev A. A. , Bazhan S. I.
Published: March 2019

Aim. The aim of the study was to evaluate the ability of pMEL-TCI and pMEL-A0201 DNA-constructs encoding artificial polyepitope melanoma antigens to induce antitumor T cell immune response ex vivo. material and methods. Dendritic cells were obtained from peripheral blood mononuclear cells of HLA-A02:01-positive donors; DCs transfected with target DNA vaccine constructions were co-cultured with autologous T lymphocytes to stimulate anti-tumor effector T cells. Specific activity of ex vivo stimulated PBMC was assessed (1) by their ability to cause lysis of human melanoma Mel Is cells, and (2) by the level of their granzyme-producing activity. A recombinant plasmid encoding the full-length MART-1 melanoma antigen was used as a positive control. results. All DNA vaccine constructions as well as positive control construction were found to be able to stimulate specific anti-tumor immune responses of autologous PBMC ex vivo, and these PBMC were found to induce melanoma Mel Is cells lysis. Both the efficiency of induced cytotoxic responses and the level of granzymes production stimulated with DCs transfected with pMel-A0201 significantly exceeded those stimulated with DCs transfected with either pMel-TCI or with DNA construction encoding the full-length MART-1 protein. The cytotoxicity level correlates with the level of granzyme B production in CD8+ T lymphocytes. conclusion. DNA vaccine constructions encoding artificial polypeptides composed of tumor antigen epitopes can stimulate the antitumor cytotoxic response. This approach can be used as the basis for the development of new methods of immunotherapy for cancer.
Medical care for children with cancer in the Siberian Federal District
Authors: Rykov M. Yu.
Published: March 2019

background. The analysis of the quality of medical care for children with cancer is based on statistical data. Evaluation of the results obtained is also the basis of the strategy for the development of medical care for this category of patients. aim: analysis of the main parameters characterizing medical care for children with cancer in the Siberian Federal District. material and methods. The reports for 2017 on the health protection of 11/12 (91.6 %) constituent entities of the Russian Federation belonging to the Siberian Federal District were analyzed (Irkutsk Region did not provide data). results. In 2017 the number of children aged 0–17 years was 3 722 470, the number of pediatric hospital beds for children with cancer (ages 0–17 years) was 260 (0,7 per 10,000), and the average number of bed-days per year was 342.2. In 3 (25 %) constituent entities of the Russian Federation, there were no departments of pediatric oncology and in 1 (8,3 %) there were no hospital beds for children with cancer. The number of physicians, who specialized in children’s cancer was 49, of them 32 (65,3 %, 0,08 per 10,000, ages 0–17 years) had a certificate of a pediatric oncologist. In 1 (8,3 %) constituent entity of the Russian Federation, there were no pediatric oncologists. For children aged 0–17 years, the cancer incidence rate was 11.7 per 100,000 children, the cancer mortality rate was 2,2 per 100,000, and one-year mortality rate was 7,4 %. 188 (43,2 %) primary cancer patients were referred to medical institutions of the Federal District, and 17 (3,9 %) primary patients left the territory of the Russian Federation. conclusion. The low incidence and mortality rates can be explained by the lost of reliable follow-up data. It is advisable to introduce electronic health record systems. For reliable estimation of hospital bed supply for children with cancer and percent of patients referred to medical centers for treatment, it is necessary to carry out a clinical audit. Deficiency of pediatric oncologists should be eliminated by reforming the training of medical personnel.
Pharmacological correction of pathological changes in the viable offspring of rats, caused by cytostatic impact at the stage of progenesis
Authors: Borovskaya T. G. , Poluektova M. E. , Vychuzhanina А. V. , Shchemerovа Yu. А. , Goldberg V. E.
Published: March 2019

Background. The number of reproductive-aged women with cancer, who desire child bearing, has increased with improvements in cancer detection and treatment. Cancer treatments have the potential to cause germline mutations that might increase the risk of cancer in the progeny of cancer patients. the aim of the study was to assess the feasibility of reducing the long-term side effects of Etoposide on the progeny of rats using Glutaxim. material and methods. Forty-five white outbred female Wistar rats, 2.5-month-old, were divided into 3 groups. Group I consisted of 15 intact rats. Group II comprised 15 rats treated with cytostatic drug (the control group). Group III consisted of 15 rats treated with Glutoxim® (Glutayil-Cysteinyl-Glycine, Pharma Vam Ltd., Russia) at a dose of 50 μg/kg 5 days before and 5 days after receiving cytostatic drug. results. An increase in the number of fetuses with external hemorrhages and pathological changes in internal organs was found in the progeny of female rats receiving Etoposide 3 months before mating. The progeny experienced a decrease in the rate of formation of sensory-motor reflexes, ability to learn and adaptive behavior. All studied parameters did not differ from background values in the progeny of female rats treated with combination of Etoposide and Glutoxim. conclusion. Glutaxim is the effective drug for correction of pathological changes in the progeny of female rats receiving cytostatic drugs.
Phenotypic plasticity of metastatic melanoma
Authors: Mikhaylova I. N. , Аnurova O. A. , Lushnikova A. A. , Tsyganova I. V. , Senderovich А. S. , Kondratieva T. Т. , Demidov L. V. , Mazurenko N. N.
Published: March 2019

Introduction. Metastatic melanoma is characterized by clinical and morphological heterogeneity and plasticity. Rare cases of metastatic melanoma are known, that have no visual expression of melanocytic markers. Contradictory histology of such melanomas requires a differential diagnosis from morphologically similar non- melanocytic tumors, sarcoma or lymphoma. objective is to describe the extraordinary cases of metastatic melanomas with low expression of differentiation markers. material and methods. 15 melanoma cases with unusual clinical and morphological characteristics were included in the study. These tumors were examined by pathologist and cytologist, by immunohistochemical and FISH analyses, mutations in BRAF, NRAS and KIT genes were detected by PCR. results. Some primary tumors were amelanotic, therefore, they were difficult for differential tumor diagnosis. Most frequently, primary tumors were located on the back, shin or head. In 4 patients the primary focuses were not detected. Metastatic lesions were as large nodular tumors in soft tissues of the back or lower limb. Most tumors belong to mixed or spindle-cell histological types. Spindle-shaped cells were also revealed by cytological analysis. BRAF gene mutations were identified by genetic analysis in 27 % of tumors, NRAS and KIT gene mutations were not detected. In 4 cases FISH analysis was performed to detect EWSR1 gene rearrangements, but it did not confirm the diagnosis of sarcoma. conclusion. The results indicate the presence of a heterogeneous group of melanoma cases, which have a number of morphological and molecular features that bring them closer to sarcomas.
Approach to robust multi-objective optimization and probabilistic analysis: the ROPAR algorithm
Authors: Marquez-Calvo Oscar O. , Solomatine Dimitri P.
Published: March 2019

This paper considers the problem of robust optimization, and presents the technique called Robust Optimization and Probabilistic Analysis of Robustness (ROPAR). It has been developed for finding robust optimum solutions of a particular class in model-based multi-objective optimization (MOO) problems (i.e. when the objective function is not known analytically), where some of the parameters or inputs to this model are assumed to be uncertain. A Monte Carlo simulation framework is used. It can be straightforwardly implemented in a distributed computing environment which allows the results to be obtained relatively fast. The technique is exemplified in the two case studies: (a) a benchmark problem commonly used to test MOO algorithms (a version of the ZDT1 function); and (b) a design problem of a simple storm drainage system, where the uncertainty is associated with design rainfall events. It is shown that the design found by ROPAR can adequately cope with these uncertainties. The approach can be useful for assisting in a wide range of risk-based decisions.
Influence of container cleanliness, container disinfection with chlorine, and container handling on recontamination of water collected from a water kiosk in a Kenyan slum
Authors: Meierhofer Regula , Wietlisbach Basil , Matiko Carol
Published: March 2019

The study assessed whether using clean containers that had been disinfected with chlorine at a water kiosk in the Kangemi slum in Nairobi reduced recontamination of treated water during drinking transport and storage. At the same time, the impacts of container handling and hygiene conditions at the household level on water quality changes during storage were evaluated. Data were collected during interviews with 135 households using either new, clean Maji Safi containers (MSCs) that had been disinfected with chlorine or normal uncleaned jerrycans (NJCs). Bacteriological water quality and free chlorine levels in both types of containers were measured after container filling at the kiosk and in the same containers after 24 h storage in households. The use of MSCs significantly reduced the risk of recontaminating the treated water. After water filling at the kiosk, none of the MSCs contained Escherichia coli bacteria, and 2.8% were contaminated after 24 h storage. In contrast, 6.2% of NJCs were contaminated after filling, and 15.2% after 24 h storage. Multivariate logistic regression indicated that the use of a clean water container and sufficient chlorine and the frequency of cleaning the container in the household mitigated recontamination. We suggest further investigation of water container designs that facilitate cleaning.
Women, irrigation and social norms in Egypt: ‘The more things change, the more they stay the same?’
Authors: Najjar Dina , Baruah Bipasha , El Garhi Aman
Published: March 2019

This paper explores how women and men participate in irrigation activities in Egypt, drawing from a survey administered to 200 men and 202 women and qualitative information from 150 interviews. Women participated in irrigation activities in 78% of the 402 households surveyed, suggesting that women are far more actively engaged in irrigation efforts in Egypt, and possibly in the wider MENA region, than is generally assumed. The diffusion of certain irrigation technologies such as drip, sprinkler and tatweer in recent years has made irrigation more socially acceptable for women to perform although some women had also been irrigating land long before these technologies became available. We identify land ownership, educational attainment, institutional support from government, donors and NGOs, and access to training in irrigational technologies as factors that enable women to optimally undertake irrigation. These factors enabled women to participate meaningfully in public institutions related to irrigation, such as water user associations (WUAs). Finally, we discovered that desire and ability to participate in WUAs declined dramatically for both women and men when institutional support was withdrawn or eroded. Thus, the paper concludes that we must look at a variety of social categories and relationships to understand women's involvement in irrigation and to identify ways to strengthen it.
A critical review of the Ganges Water Sharing arrangement
Authors: Rahman Kazi Saidur , Islam Zahidul , Navera Umme Kulsum , Ludwig Fulco
Published: February 2019

The 1996 Ganges Water Sharing Treaty was an important breakthrough in solving disputes over sharing Ganges water between India and Bangladesh. This study evaluates cooperation reflected in the Treaty by performing a quantitative analysis on available water sharing data. The study recognized that inaccurate projection of future flow and the obligation of allocating guaranteed 991 m3/s flows perpetuate the ongoing water sharing conflicts. The provision of guaranteed minimal flow alternately to India and Bangladesh during critical periods leads to frequent occurrences of low-flow events. Results indicated that the Treaty underestimated the impact of climate variability and possibly increasing upstream water abstraction. Statistical analysis of the post-Treaty data (1997–2016) also indicated that 65% of the time Bangladesh did not receive its guaranteed share during critical dry periods with high water demand. It is advised to project the reliable water availability using a combination of modelling and improved observation of river flows. In addition, the condition of minimum guaranteed share should be removed to reduce the frequency of low-flow events in future. Although our analyses show a number of weaknesses, the Treaty could still enhance the future regional cooperation if some adjustments are made to the current terms and conditions.
Correlation Between Pyridoxal 5’-Phospate Level And Valproic Acid In Epilepsy Children
Authors: Suwarba I Gusti Ngurah Made , Novayanti Ni Putu Yunik , Sidiartha I Gusti Lanang , Mahalini Dewi Sutriani
Published: March 2019

Background: It is important to maintain the adequate level of vitamin B6 to ensure stable metabolism. Vitamin B6 serum level might decreased by absorption disturbance or increasing demand. Valproic acid increase the synthesis of serum GABAergic in the other hand vitamin B6 is required as cofactor for gamma-amino butyric acid (GABA) formation. The dosage and duration of valproic acid therapy might be correlated with vitamin B6 serum level. The aim of this study is to know the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy in children with epilepsy.Materials and Methods: This is a cross sectional study to investigate the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy. The level of vitamin B6 serum was determined by checking vitamin B6 active form in serum, pyridoxal 5’-phospate (PLP).Results: In this study, 37 epilepsy children with valproic acid duration therapy more than 3 months was enrolled. Fifty six percent epilepsy children were male, commonly on children age 1-5 years old. Spearman correlation coefficient test showed a significant weak negative correlation between vitamin B6 serum level and dosage of valproic acid (r=–0.35; p=0.03), and very weak negative correlation with valproic acid duration therapy (r=-0.08; p=0.59), however it was not significant. Conclusion: There was a significant weak negative correlation between vitamin B6 serum level and very weak negative correlation with valproic acid duration therapy, but not significant in children with epilepsy.Keywords: correlation, valproic acid, vitamin B6
Cytotoxic Activity of Methoxy-4’amino Chalcone Derivatives Against Leukemia Cell Lines
Authors: Novilla Arina , Mustofa Mustofa , Astuti Indwiani , Jumina Jumina , Suwito Hery
Published: March 2019

Background: Chemotherapy is a common treatment for leukemia as well as in other cancer treatment. The lack of tumor selectivity and development of multi-drug resistance by chemotherapy caused the development of new strategy in cancer treatment become a pressing need. This study was performed to evaluate the anticancer activity and selectivity of seven derivatives of chalcones against K562 and HL-60 leukemia cell lines. Materials and Methods: The cytotoxicity of chalcone’s seven derivatives (compound 1-7) was tested by using MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxyme-thoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) method. The percentage of cell mortality data was calculated then the IC50 was analyzed using probit analysis (SPSS 17). The selectivity index (SI) then calculated from IC50 ratio of normal lymphocyte cells and cancerous cells line (HL-60 and K562).Results: The IC50 of almost all seven tested compounds were lower in HL-60 cell lines than K562 cell lines, except for Compound 7. The number and position of methoxy groups in chalcone derivatives influenced the anticancer and cancer selectivity of chalcone derivatives.Conclusion: The results revealed that the number and position of methoxy groups in chalcone derivatives influenced the anticancer and cancer selectivity of chalcone derivatives.Keywords: anticancer, chalcone derivatives, methoxy-4’-amino chalcone, leukemia, cytotoxic, selectivity
Efficacy and Toxicity of Addition of Bevacizumab to Chemotherapy in Patients with Metastatic Colorectal Cancer
Authors: Ruan Wen-Cong , Che Yue-Ping , Ding Li , Li Hai-Feng
Published: February 2019

Background:

Pre-treated patients with first-line treatment can be offered a second
treatment with the aim of improving their poor clinical prognosis. The therapy of metastatic
colorectal cancer (CRC) patients who did not respond to first-line therapy has limited treatment
options. Recently, many studies have paid much attention to the efficacy of bevacizumab as an
adjuvant treatment for metastatic colorectal cancer.

Objectives:

We aimed to evaluate the efficacy and toxicity of bevacizumab plus chemotherapy
compared with bevacizumab-naive based chemotherapy as second-line treatment in people with
metastatic CRC.

Methods:

Electronic databases were searched for eligible studies updated to March 2018.
Randomized-controlled trials comparing addition of bevacizumab to chemotherapy without
bevacizumab in MCRC patients were included, of which, the main interesting results were the
efficacy and safety profiles of the addition of bevacizumab in patients with MCRC as second-line
therapy.

Result:

Five trials were eligible in the meta-analysis. Patients who received the combined
bevacizumab and chemotherapy treatment in MCRC as second-line therapy showed a longer overall
survival (OS) (OR=0.80,95%CI=0.72-0.89, P<0.0001) and progression-free survival (PFS)
(OR=0.69,95%CI=0.61-0.77, P<0.00001). In addition, there was no significant difference in
objective response rate (ORR) (RR=1.36,95%CI=0.82-2.24, P=0.23) or severe adverse event (SAE)
(RR=1.02,95%CI=0.88-1.19, P=0.78) between bevacizumab-based chemotherapy and bevacizumabnaive
based chemotherapy.

Conclusion:

Our results suggest that the addition of bevacizumab to the chemotherapy therapy
could be an efficient and safe treatment option for patients with metastatic colorectal cancer as
second-line therapy and without increasing the risk of an adverse event.
A Novel Approach of Solving Output Displacement of Compliant Mechanism Based on Integration Method
Authors: Gong Jinliang , Li Xiang , Zhang Yanfei , Mostafa Kazi
Published: February 2019

Background:

Micro-positioning platform is a device with high accuracy of positioning and
a certain range of motion. Accuracy of the micro-positioning mechanism is ensured by using a flexible
hinge to replace the traditional motion pair.

Objective:

A two-dimensional micro-positioning platform is proposed in this study. It is necessary to
find out how the geometric parameters affect the output displacement of the amplification structure
component. Thus, this paper aims to build up the relation model of stiffness and geometric parameters.

Method:

A novel method for building the relational model of parameters and output displacement is
introduced on the basis of the superposition principle of small deformation and the principle of deflection.
Firstly, the amplification structure is divided into different units according to the section shape
and force. Secondly, the parametric model of integral deflection curve of the amplification structure is
solved. The method is based on the flexibility matrix of the flexible hinge unit and the differential
equation of the deflection curve of the rectangular unit. Finally, the parametric model of output displacement
is established by using the integral deflection curve equation and geometric relationship between
adjacent deformations of the compliant structure.

Result:

It is shown that the output displacements by analysis method are close to the results achieved
by the ANSYS software, with a maximal difference of 15.3%. The reason is that the integral deflection
curve is not smooth at some special points, which is verified by finite element analysis.
A Clinical Care Monitoring and Data Collection Tool (H3 Tracker) to Assess Uptake and Engagement in Mental Health Care Services in a Community-Based Pediatric Integrated Care Model: Longitudinal Cohort Study
Authors: McCreary Michael , Arevian Armen C , Brady Madeline , Mosqueda Chichits Ana E , Zhang Lily , Tang Lingqi , Zima Bonnie
Published: March 2019

Background

National recommendations for pediatric integrated care models include improved capacity for care coordination and communication across primary care and specialty mental health providers using technology, yet few practical, short-term solutions are available for low-resource, community-based pediatric integrated care clinics.

Objective

The goal of the paper is to describe the development and features of a Web-based tool designed for program evaluation and clinician monitoring of embedded pediatric mental health care using a community-partnered approach. In addition, a longitudinal study design was used to assess the implementation of the tool in program evaluation, including clinical monitoring and data collection.

Methods

Biweekly meetings of the partnered evaluation team (clinic, academic, and funding partners) were convened over the course of 12 months to specify tool features using a participatory framework, followed by usability testing and further refinement during implementation.

Results

A data collection tool was developed to collect clinic population characteristics as well as collect and display patient mental health outcomes and clinical care services from 277 eligible caregiver/child participants. Despite outreach, there was little uptake of the tool by either the behavioral health team or primary care provider.

Conclusions

Development of the H3 Tracker (Healthy Minds, Healthy Children, Healthy Chicago Tracker) in two community-based pediatric clinics with embedded mental health teams serving predominantly minority children is feasible and promising for on-site program evaluation data collection. Future research is needed to understand ways to improve clinic integration and examine whether promotion of primary care/mental health communication drives sustained use.

Trial Registration

ClinicalTrials.gov NCT02699814; https://clinicaltrials.gov/ct2/show/NCT02699814 (Archived by WebCite at http://www.webcitation.org/772pV5rWW)
What Patients Value in Physicians: Analyzing Drivers of Patient Satisfaction Using Physician-Rating Website Data (Preprint)
Authors: Bidmon Sonja , Elshiewy Ossama , Terlutter Ralf , Boztug Yasemin
Published: February 2019

BACKGROUND

Customer-oriented health care management and patient satisfaction have become important for physicians to attract patients in an increasingly competitive environment. Satisfaction influences patients’ choice of physician and leads to higher patient retention and higher willingness to engage in positive word of mouth. In addition, higher satisfaction has positive effects on patients’ willingness to follow the advice given by the physician. In recent years, physician-rating websites (PRWs) have emerged in the health care sector and are increasingly used by patients. Patients’ usage includes either posting an evaluation to provide feedback to others about their own experience with a physician or reading evaluations of other patients before choosing a physician. The emergence of PRWs offers new avenues to analyze patient satisfaction and its key drivers. PRW data enable both satisfaction analyses and implications on the level of the individual physician as well as satisfaction analyses and implications on an overall level.

OBJECTIVE

This study aimed to identify linear and nonlinear effects of patients’ perceived quality of physician appointment service attributes on the overall evaluation measures that are published on PRWs.

METHODS

We analyzed large-scale survey data from a German PRW containing 84,680 surveys of patients rating a total of 7038 physicians on 24 service attributes and 4 overall evaluation measures. Elasticities are estimated from regression models with perceived attribute quality as explanatory variables and overall evaluation measures as dependent variables. Depending on the magnitude of the elasticity, service attributes are classified into 3 categories: attributes with diminishing, constant, or increasing returns to overall evaluation.

RESULTS

The proposed approach revealed new insights into what patients value when visiting physicians and what they take for granted. Improvements in the physicians’ pleasantness and friendliness have increasing returns to the publicly available overall evaluation (b=1.26). The practices’ cleanliness (b=1.05) and the communication behavior of a physician during a visit (b level between .97 and 1.03) have constant returns. Indiscretion in the waiting rooms, extended waiting times, and a lack of modernity of the medical equipment (b level between .46 and .59) have the strongest diminishing returns to overall evaluation.

CONCLUSIONS

The categorization of the service attributes supports physicians in identifying potential for improvements and prioritizing resource allocation to improve the publicly available overall evaluation ratings on PRWs. Thus, the study contributes to patient-centered health care management and, furthermore, promotes the utility of PRWs through large-scale data analysis.
Advancing the Science of Recruitment for Family Caregivers: Focus Group and Delphi Methods (Preprint)
Authors: Hansen Dana , Petrinec Amy , Hebeshy Mona , Sheehan Denice , Drew Barbara L
Published: March 2019

BACKGROUND

Successful recruitment of participants is imperative to a rigorous study, and recruitment challenges are not new to researchers. Many researchers have used social media successfully to recruit study participants. However, challenges remain for effective online social media recruitment for some populations.

OBJECTIVE

Using a multistep approach that included a focus group and Delphi method, researchers performed this study to gain expert advice regarding material development for social media recruitment and to test the recruitment material with the target population.

METHODS

In the first phase, we conducted a focus group with 5 social media experts to identify critical elements for effective social media recruitment material. Utilizing the Delphi method with 5 family caregivers, we conducted the second phase to reach consensus regarding effective recruitment videos.

RESULTS

Phase I utilized a focus group that resulted in identification of three barriers related to social media recruitment, including lack of staff and resources, issues with restrictive algorithms, and not standing out in the crowd. Phase II used the Delphi method. At the completion of Delphi Round 1, 5 Delphi participants received a summary of the analysis for feedback and agreement with our summary. Using data and recommendations from Round 1, researchers created two new recruitment videos with additions to improve trustworthiness and transparency, such as the university’s logo. In Round 2 of the Delphi method, consensus regarding the quality and trustworthiness of the recruitment videos reached 100%.

CONCLUSIONS

One of the primary challenges for family caregiver research is recruitment. Despite the broad adoption of social media marketing approaches, the effectiveness of online recruitment strategies needs further investigation.
Mobile and Connected Health Technology Needs for Older Adults Aging in Place: Cross-Sectional Survey Study (Preprint)
Authors: Wang Jing , Du Yan , Coleman Deidra , Peck Michelle , Myneni Sahiti , Kang Hong , Gong Yang
Published: March 2019

BACKGROUND

An increasing number of mobile and wearable devices are available in the market. However, the extent to which these devices can be used to assist older adults to age in place remains unclear.

OBJECTIVE

This study aimed to assess older adults’ perceptions of using mobile and connected health technologies.

METHODS

Using a cross-sectional design, a total of 51 participants were recruited from a senior community center. Demographics and usage of mobile or wearable devices and online health communities were collected using a survey questionnaire. Descriptive statistics assessed usage of devices and online health communities. The Fisher exact test was used to examine the relationship between technology usage and having access to a smartphone.

RESULTS

The sample was primarily comprised non-Hispanic white (35/51, 69%), educated (39/51, 76% any college), and female (36/51, 71%) participants, with an average age of 70 (SD 8) years. All participants were insured and nearly all lived at home (49/51, 94%). A total of 86% (44/51) of the participants had heard of wearable health devices, but only 18 out of 51 (35%) had ever used them. Over 80% (42/51) expressed interest in using such devices and were interested in tracking exercise and physical activity (46/51, 90%), sleep (38/51, 75%), blood pressure (34/51, 67%), diet (31/51, 61%), blood sugar (28/51, 55%), weight (26/51, 51%), and fall risk (23/51, 45%). The greatest concerns about using wearable devices were cost (31/51, 61%), safety (14/51, 28%), and privacy (13/51, 26%); one-fourth (12/51) reported having no concerns. They were mostly interested in sharing data from mobile and connected devices with their health care providers followed by family, online communities, friends, and no one. About 41% (21/51) of the older adults surveyed reported having ever heard of an online health community, and roughly 40% (20/51) of the participants reported being interested in joining such a community. Most participants reported having access to a smartphone (38/51, 74%), and those with such access were significantly more likely to show interest in using a wearable health device (P<.001) and joining an online health community (P=.05).

CONCLUSIONS

Our findings suggest that, although few older adults are currently using mobile and wearable devices and connected health technologies for managing health, they are open to this idea and are mostly interested in sharing such data with their health care providers. Further studies are warranted to explore strategies to balance the data sharing preference of older adults and how to best integrate mobile and wearable device data with clinical workflow for health care providers to promote healthy aging in place.
KAJIAN KETIMPANGAN WILAYAH DI KAWASAN SUBOSUKAWONOSRATEN TAHUN 2001-2016
Authors: Sari Yetti Anita , Giyarsih Sri Rum , Pangaribowo Evita Hanie
Published: March 2019

Regional disparity was a common problem in developing countries. Different regional potentials result in disparity between regions. This study aims to analyze regional disparity in Subosukwonosraten region during 2001-2016 and to determine factors that affect regional disparity in Subosukawonosraten. Analysis techniques used in this study were entropy theil index and panel data regression. The result showed that regional disparity in Subosukawonosraten tends to increase during 2001-2016. Showed by the results of the total theil index in 2001 was 8.8133 to 12.4879 in 2016. The results of panel data regression fixed effect with Weighted Least Squares were share indsutry sector and share agriculture sector have the negative and significant impact on regional disparity. Enrollment rate, morbidity, and population growth have the positive and significant impact on regional disparity.
Protagonista opositor, peronista desplazado: la Confederación General del Trabajo durante el gobierno de Raúl Alfonsín
Authors: Rocca Rivarola María Dolores
Published: February 2019

En este artículo, la autora analiza la evoluciónparadójica de la Confederación General del Trabajo(cgt). Por un lado, su papel protagónico dentro de laoposición durante el gobierno de Raúl Alfonsín; porotro, como fuerza en incipiente proceso de debilitamientoal interior del Partido Justicialista (pj) enel marco de la victoria de la fracción del “peronismorenovador”. El objetivo específico es comprender cómofue posible esta paradoja y el objetivo general esel examen de un periodo (1983-1989) caracterizadopor el establecimiento de las bases institucionalesde una posterior transformación sustantiva al interiordel PJ.
El espejo astillado
Authors: Araque Calderón José
Published: February 2019

Reseña del libro de José Antonio Rivas Leone, En los bordes de la democracia. La militarización de la política venezolana, prólogo de César Cansino, Mérida (Venezuela), Universidad de Los Andes, Centro de Investigaciones de Política Comparada/Consejo de Estudios de Postgrado, 2010, 212 pp.
Del Estado en crisis a la crítica del Estado. Diálogo en torno a la perspectiva del Estado y la gubernamentalidad en el análisis de la nueva cuestión social en América Latina
Authors: Giavedoni José G.
Published: February 2019

Ciertas perspectivas teóricas caracterizan al Estado en América Latina como una entidad que posee debilidad para homogeneizar la ley en todo el territorio y para hacerle frente a problemas sociales acuciantes. En este marco, se sostiene en el presente artículo que en lugar de pensar en debilidades o disfuncionalidades del Estado, es necesario pensar en una modalidad específica de gobierno sobre sectores determinados de la población, que posea finalidades estratégicas y que se despliegue en función de determinadas tecnologías que se hacen inteligibles dentro de formas discursivas específicas. Asimismo, se analiza la cuestión social a través de la noción de gobierno, cuestión que permite incorporar la dimensión de lo estatal, de lo social y de lo estratégico, evaluando las prácticas en términos productivos y no sólo en términos de disfunción o de ausencia del Estado.
Para medir la participación. Construcción y validación del Cuestionario Conductas de Participación (CCP).*
Authors: Vergara-Lope Tristán** Samana , Hevia de la Jara Felipe José
Published: February 2019

El presente artículo tiene como objetivo presentar el Cuestionario de Conductas de Participación (CCP) como instrumento válido y confiable para medir conductas de este tipo y que pueda ser utilizado para determinar niveles de participación. El CCP mide cuatro dimensiones de la participación (electoral, partidaria, asociativa-opinativa y cívica) y posee 37 reactivos. Se concluye que, luego de ser sometido a diversas pruebas estandarizadas, el CCP muestra tener confiabilidad total fuerte.
En torno a las prácticas desleales en las relaciones entre empresas en la cadena de suministro alimentario
Authors: De la Cuesta Saenz José María
Published: March 2019

La mejora del funcionamiento de la cadena de suministro alimentaria, ha concitado intensos esfuerzos por parte de la UE y de sus Estados miembros, para superar las permanentes consecuencias negativas que sus peculiaridades acarrean a las empresas situadas en los eslabones de la cadena con menor poder de negociación, especialmente después de haberse prescindido por completo a partir del año 2007 de los sistemas de intervención en los mercados utilizados hasta entonces. Tales esfuerzos se han plasmado en normas novedosas de represión de prácticas comerciales desleales, que la UE pretende armonizar mediante la propuesta de una Directiva, pero también a través de la potencialidad reguladora de los contratos con tal finalidad y de los contratos en red.
Panorama del régimen de seguridad social contenido en la ley del seguro social mexicana
Authors: Marquet Guerrero Porfirio
Published: March 2019

La Seguridad Social es una disciplina relativamente reciente, si se considera que la mayoría de los especialistas coinciden en que sus primeros antecedentes claros se remontan apenas al último tercio del siglo XIX, cuando Otto Von Bismarck promovió en Prusia las primeras leyes que crearon seguros sociales. Se consolidó de manera importante durante el siglo XX y particularmente en México con la expedición de la primera Ley del Seguro Social que entró en vigor en enero de 1943, la cual fue sustituida por la segunda que entró en vigor en 1973 y ésta a su vez por la actual que inició su vigencia en 1997, que por diversas razones es la más importante en México.
El emprendimiento como alternativa al empleo ordinario en las personas con discapacidad.
Authors: Moreno Rodríguez Ricardo
Published: March 2019

Como consecuencia de las limitaciones que encuentran las personas con discapacidad para el acceso al empleo ordinario, el autoempleo y el emprendimiento constituyen la alternativa por la que se opta, a fin de incorporarse al área ocupacional productiva. Se analiza en este trabajo las principales iniciativas en España dirigidas al fomento del emprendimiento y se aportan las principales actuaciones y resultados obtenidos por el Grupo de Investigación en cuanto al fomento del emprendimiento de las personas con discapacidad.
La seguridad social en México y el futuro que nos espera en el siglo XXI
Authors: Ruiz Moreno Ángel Guillermo
Published: March 2019

El Estado mexicano requiere tomar acciones urgentemente para combatir el rezago en el que se encuentra su sistema de seguridad social actualmente. Este trabajo aborda la forma en que fue construido el sistema de seguridad social mexicano, qué características posee el derecho humano a la seguridad social en México, cuáles son las frágiles bases en que se apoya nuestro sistema protector y, ante este panorama, se propone la búsqueda de un sistema universal de seguridad social respaldado con la correspondiente transformación llevada a cabo en la estructura constitucional del país, con el objetivo de que la estabilidad social en México no desaparezca ni adolezca de principios jurídicos clave ante los cambios de paradigma y transformaciones que implica la disrupción de la Cuarta Revolución Industrial en la sociedad.
Economía colaborativa: un desafío más para la seguridad social
Authors: Morales Ramírez María Ascensión
Published: March 2019

La seguridad social a más de siete décadas de su surgimiento y de constituir un derecho humano no ha logrado materializarse. Por su parte, la protección basada en el seguro social cada vez enfrenta más y nuevos retos. Sin embargo, ambos modelos en la actualidad se ven afectados por las nuevas formas atípicas de empleo, así como por la informalidad, el subempleo, el desempleo y el envejecimiento de la población en dos de sus aspectos principales: el acceso y extensión de su cobertura protectora y en su financiamiento.
El derecho de huelga: ¿Un derecho fundamental excepcional?
Authors: Ambesi Leonardo J.
Published: March 2019

Como consecuencia de las limitaciones que encuentran las personas con discapacidad para el acceso al empleo ordinario, el autoempleo y el emprendimiento constituyen la alternativa por la que se opta, a fin de incorporarse al área ocupacional productiva. Se analiza en este trabajo las principales iniciativas en España dirigidas al fomento del emprendimiento y se aportan las principales actuaciones y resultados obtenidos por el Grupo de Investigación en cuanto al fomento del emprendimiento de las personas con discapacidad.

 
A propósito de la penúltima modificación de la Ley del Patrimonio Sindical Acumulado en España
Authors: Barbancho Tovillas Fernando
Published: March 2019

En la configuración del patrimonio de los sindicatos en España juegan un papel determinante la cesión de uso de los bienes del patrimonio sindical acumulado y la restitución o compensación económica de los bienes incautados a los sindicatos con motivo de la Guerra Civil –patrimonio sindical histórico–. Su regulación, la aplicación por parte del Gobierno y la interpretación jurisprudencial desde hace más de 30 años, aún no han cerrado todas las cuestiones.
La conceptualización de la discapacidad a través de la historia: una mirada a través de la evolución normativa
Authors: López Bastías José Luis
Published: March 2019

La posición social de las personas con discapacidad ha cambiado enormemente a lo largo de la historia, desde un modelo denominado como tradicional o de la prescindencia, el cual relegaba a las personas con discapacidad a una situación de exclusión y segregación, a otro modelo social que, basado en la autonomía personal y la autodeterminación, tiene como meta compartida principal, por todos los agentes sociales, la inclusión y la igualdad de derechos. El presente trabajo tiene como objeto describir la evolución histórica en la conceptualización de la discapacidad, centrada sobre todo en España, a través de la diferente normativa y legislación en las diferentes etapas históricas, desde la antigüedad hasta el momento presente. Palabras clave: Emprendimiento; inclusión; personas con discapacidad; empleo; autoempleo.
Pengaruh Pendidikan Kesehatan Menstrual Hygiene (PMH) Terhadap Sikap Remaja Putri dalam Menjaga Kebersihan Diri Selama Menstruasi
Authors: Meinarisa Meinarisa
Published: March 2019

WHO reported that the women mortality and morbidity due to reproductive system disorders increased in last decade. One of the cause the reproductive tract infection is unhygiene during menstruation. This study aims to examine the effect of Menstrual Hygiene (PMH) health education on the attitudes of adolescent girls in maintaining personal hygiene during menstruation and this research is a quasi-experiment with pre-test and post-test with control group. 98 adolescent girls from junior high school has participate in this research, 48 respondents in intervention group  have been given the Menstrual Hygiene Education through lectures, direct demonstration using phantom, booklet and self-report filling during menstruation. The questionnaire that used is Adolescent Menstrual Attitude Questionnaire to measure the attitude of adolescent girls. The results showed Menstrual Hygiene Education (MHE) there was  influence  of adolescent girls in monitoring personal hygiene during menstruation p=0,001 (95% CI 223,38 – 234,17). MHE improved the attitude of adolescent girls and helps the adolescents to understand personal hygiene during menstruation. This research recommend MHE can use by nurses for health education in school health unit.

Angka kematian dan kecacatan pada wanita karena gangguan sistem reproduksi semakin meningkat. Salah satu penyebabnya adalah infeksi organ reproduksi dan infeksi organ perkemihan. Penyakit infeksi disistem reproduksi dapat disebabkan karena kebersihan yang kurang dari wanita saat menstruasi. Penelitian ini bertujuan menguji pengaruh Pendidikan kesehatan Menstrual Hygiene (PMH) terhadap sikap remaja putri dalam menjaga kebersihan diri selama menstruasi dan merupakan penelitian quasi-experiment dengan pretest and posttest with control group. Sejumlah 98 remaja putri dari Sekolah Menengah Pertama (SMP) N 24 dan 3 kota Jambi berpartisipasi dalam penelitian, 48 orang pada kelompok intervensi diberikan Pendidikan kesehatan Menstrual Hygiene (PMH) melalui ceramah, demostrasi langsung menggunakan phantom dan pemberian booklet. Serta pengisian self-report selama menstruasi.  Kuesioner yang digunakan adalah Adolescent Menstrual Attitude Questionnaire untuk mengukur sikap remaja putri. Hasil penelitian menunjukkan ada pengaruh PMH terhadap sikap remaja putri dalam menjaga kebersihan diri selama menstruasi p=0,001 (95% CI 223,38 – 234,17). PMH meningkatkan sikap remaja putri dan membantu remaja untuk memahami kebersihan diri selama menstruasi. Penelitian ini merekomendasikan PMH digunakan oleh perawat dalam penyuluhan kesehatan di Unit Kesehatan Sekolah (UKS).