bluuebunny/crossref_metadata_2025 huggingface dataset:
Люминесцентный отклик фотонных кристаллов со встроенными Ge наноостровками с различной глубиной травления отверстий
Authors: Юрасов Д.В. , Яблонский А.Н. , Шалеев М.В. , Шенгуров Д.В. , Родякина Е.Е. , Смагина Ж.В. , Вербус В.А. , Новиков А.В.
Published: April 2023

Two-dimensional Si-based photonic crystals with embedded Ge nanoislands were studied. In particular, dependences of the steady-state and time-resolved photoluminescence response on the depth of the air-holes which form the photonic crystal itself were investigated. It was shown that the maximum luminescence intensity was observed not for the fully-etched photonic crystals but for the intermediately etched ones. The possible origin of such a behavior is discussed.
Высокоселективный волноводный полосно-пропускающий фильтр с уровнем подавления помех более 120 dB
Authors: Беляев Б.А. , Сержантов А.М. , Лексиков Ан.А. , Бальва Я.Ф. , Александровский А.А. , Галеев Р.Г.
Published: April 2023

The design of a 10th-order waveguide bandpass filter with an additional inductive cross-coupling between non-adjacent resonators has been proposed and studied. An inductive coupling is formed by a U-shaped conductor structure with grounded ends that is formed in the filter cover. This method of cross-coupling organization ensures not only the temperature stability of the characteristics, but also the manufacturability of the structure. The high selectivity of the device is achieved by both the attenuation poles located near the passband, as well as the level of suppression in the stopbands, exceeding 120 dB. The passband loss of the fabricated filter is ~0.8 dB at its central frequency f0 = 18.2 GHz and relative bandwidth Δf / f0 = 1.5%. The small dimensions (135×30×10 mm3) and the weight of about 200 g of the device, with simultaneously high electrical characteristics show the promise of its use, for example, in on-board and ground-based space communication systems.
Mobile Apps and Quality of Life in Patients With Breast Cancer and Survivors: Systematic Literature Review
Authors: Saevarsdottir Saeunn Rut , Gudmundsdottir Sigridur Lara
Published: April 2023

Background

Side effects of breast cancer treatment may persist long into survivorship, reducing quality of life (QOL) in patients with breast cancer and survivors. There is growing evidence for the use of digital health technologies, such as mobile apps, to support self-management, decrease symptom burden, and improve QOL in patients with cancer. However, an updated overview of the effects of mobile apps on QOL and well-being in patients with breast cancer and survivors is needed.

Objective

The aim of this review was to provide an overview of breast cancer–specific, mobile app–driven lifestyle or behavioral interventions in patient care through to survivorship and their impact on QOL and mental well-being.

Methods

A systematic search of PubMed, Scopus, and Web of Science was conducted to identify relevant studies. The inclusion criteria were limited to original studies involving a trial of a mobile app–driven lifestyle or behavioral intervention for patients with breast cancer or survivors and using QOL or well-being measures. The results of the studies that met the inclusion criterion were then synthesized in text and table format. The quality of the evidence was assessed with the Cochrane risk-of-bias tool.

Results

A total of 17 studies with the number of participants ranging from 23 to 356 met the inclusion criterion. Of the 17 reviewed studies, 7 (41%) delivered an app-only intervention, and 10 (59%) combined an app with additional supporting materials, such as SMS text messaging, telecoaching, wearables, or printed materials. Among the 17 reviewed studies, 6 (35%) focused on aiding patients with breast cancer during the active treatment phase (excluding ongoing hormone therapy), whereas the remaining 11 (65%) focused on survivorship. The majority of the studies (14/17, 82%) observed some positive effects on QOL or well-being measures.

Conclusions

The results of the review indicate that mobile apps are a promising avenue for improving QOL and well-being in breast cancer care. Positive effects were observed in patients undergoing active treatment in all reviewed studies, but effects were less clear after chemotherapy and in long-term survivors. Although lifestyle and behavioral digital interventions are still being developed, and further research should still be pursued, the available data suggest that current mobile health apps aid patients with breast cancer and survivors.
How Older Indigenous Women Living in High-Income Countries Use Digital Health Technology: Systematic Review (Preprint)
Authors: Henson Connie , Chapman Felicity , Shepherd Gina , Carlson Bronwyn , Rambaldini Boe , Gwynne Kylie
Published: April 2023

BACKGROUND

Research associated with digital health technologies similar to the technologies themselves has proliferated in the last 2 decades. There are calls for these technologies to provide cost-effective health care for underserved populations. However, the research community has also underserved many of these populations. Older Indigenous women are one such segment of the population.

OBJECTIVE

Our objective is to systematically review the literature to consolidate and document what we know about how older Indigenous women living in high-income countries use digital health technology to enhance their health.

METHODS

We analyzed the peer-reviewed literature by systematically searching 8 databases in March 2022. We included studies published between January 2006 and March 2022 with original data specific to older Indigenous women from high-income countries that reported on the effectiveness, acceptability, and usability of some user-focused digital health technology. We incorporated 2 measures of quality for each study. We also conducted a thematic analysis and a lived experience analysis, which examined each paper from the perspectives of older Indigenous women. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines in this study.

RESULTS

Three papers met the inclusion criteria. The key findings were that older Indigenous women do not see themselves reflected in mainstream health messaging or other digital health offerings. They prefer an approach that considers their uniqueness and diversity. We also identified 2 significant gaps in the literature. First, research reporting on older Indigenous women from high-income countries’ experiences with digital health technology is minimal. Second, the limited research related to older Indigenous women has not consistently engaged Indigenous people in the research process or governance.

CONCLUSIONS

Older Indigenous women want digital health technologies to respond to their needs and preferences. Research is needed to understand their requirements and preferences to ensure equity as we move toward greater adoption of digital health technology. Engaging older Indigenous women throughout the research is essential to ensuring that digital health products and services are safe, usable, effective, and acceptable for older Indigenous women.

CLINICALTRIAL
Effectiveness of Combined Health Coaching and Self-Monitoring Apps on Weight-Related Outcomes in People With Overweight and Obesity: Systematic Review and Meta-analysis (Preprint)
Authors: Chew Han Shi Jocelyn , Rajasegaran Nagadarshini Nicole , Chin Yip Han , Chew W S Nicholas , Kim Kyung Mi
Published: April 2023

BACKGROUND

Self-monitoring smartphone apps and health coaching have both individually been shown to improve weight-related outcomes, but their combined effects remain unclear.

OBJECTIVE

This study aims to examine the effectiveness of combining self-monitoring apps with health coaching on anthropometric, cardiometabolic, and lifestyle outcomes in people with overweight and obesity.

METHODS

Relevant articles published from inception till June 9, 2022, were searched through 8 databases (Embase, CINAHL, PubMed, PsycINFO, Scopus, The Cochrane Library, and Web of Science). Effect sizes were pooled using random-effects models. Behavioral strategies used were coded using the behavior change techniques taxonomy V1.

RESULTS

A total of 14 articles were included, representing 2478 participants with a mean age of 39.1 years and a BMI of 31.8 kg/m2. Using combined intervention significantly improved weight loss by 2.15 kg (95% CI −3.17 kg to −1.12 kg; P<.001; I2=60.3%), waist circumference by 2.48 cm (95% CI −3.51 cm to −1.44 cm; P<.001; I2=29%), triglyceride by 0.22 mg/dL (95% CI −0.33 mg/dL to 0.11 mg/dL; P=.008; I2=0%), glycated hemoglobin by 0.12% (95% CI −0.21 to −0.02; P=.03; I2=0%), and total calorie consumption per day by 128.30 kcal (95% CI −182.67 kcal to −73.94 kcal; P=.003; I2=0%) kcal, but not BMI, blood pressure, body fat percentage, cholesterol, and physical activity. Combined interventional effectiveness was superior to receiving usual care and apps for waist circumference but only superior to usual care for weight loss.

CONCLUSIONS

Combined intervention could improve weight-related outcomes, but more research is needed to examine its added benefits to using an app.

CLINICALTRIAL

PROSPERO CRD42022345133; https://tinyurl.com/2zxfdpay
A SNOMED CT Mapping Guideline for the Local Terms Used to Document Clinical Findings and Procedures in Electronic Medical Records in South Korea: Methodological Study (Preprint)
Authors: Sung Sumi , Park Hyeoun-Ae , Jung Hyesil , Kang Hannah
Published: April 2023

BACKGROUND

South Korea joined SNOMED International as the 39th member country. To ensure semantic interoperability, South Korea introduced SNOMED CT (Systemized Nomenclature of Medicine–Clinical Terms) in 2020. However, there is no methodology to map local Korean terms to SNOMED CT. Instead, this is performed sporadically and independently at each local medical institution. The quality of the mapping, therefore, cannot be guaranteed.

OBJECTIVE

This study aimed to develop and introduce a guideline to map local Korean terms to the SNOMED CT used to document clinical findings and procedures in electronic health records at health care institutions in South Korea.

METHODS

The guidelines were developed from December 2020 to December 2022. An extensive literature review was conducted. The overall structures and contents of the guidelines with diverse use cases were developed by referencing the existing SNOMED CT mapping guidelines, previous studies related to SNOMED CT mapping, and the experiences of the committee members. The developed guidelines were validated by a guideline review panel.

RESULTS

The SNOMED CT mapping guidelines developed in this study recommended the following 9 steps: define the purpose and scope of the map, extract terms, preprocess source terms, preprocess source terms using clinical context, select a search term, use search strategies to find SNOMED CT concepts using a browser, classify mapping correlations, validate the map, and build the final map format.

CONCLUSIONS

The guidelines developed in this study can support the standardized mapping of local Korean terms into SNOMED CT. Mapping specialists can use this guideline to improve the mapping quality performed at individual local medical institutions.
The Relation Between Students’ Theoretical Knowledge and Practical Skills in Endodontics: Retrospective Analysis (Preprint)
Authors: Haupt Franziska , Kanzow Philipp
Published: April 2023

BACKGROUND

Dental undergraduate students are required to show sufficient practical skills prior to treating patients. Practical skills and the underlying theoretical knowledge are taught in preclinical courses. Usually, the learning outcome is assessed in written multiple-choice examinations (theoretical knowledge) and practical skills tests. However, students’ assessment of practical skills is more time consuming and prone to bias than objective multiple-choice examinations.

OBJECTIVE

This study aims to analyze the relation between students’ theoretical knowledge and practical skills in endodontics. Furthermore, the predictive validity of a theoretical knowledge assessment on students’ practical skills was assessed.

METHODS

Examination results from all students who participated in the preclinical phantom course in Operative Dentistry (sixth semester of the undergraduate dental curriculum in Germany) between the 2015 summer term and the 2022 summer term were retrospectively evaluated (N=447). The effects of age, sex, previous course participation, and theoretical knowledge on students’ practical skills were assessed, using Pearson correlations, Wilcoxon rank sum tests, and a linear regression analysis. Subsequently, students’ theoretical knowledge and practical skills were compared via a Fisher exact test to identify a suitable pass mark for students’ theoretical knowledge that was associated with sufficient practical skills (≥60%).

RESULTS

Students’ theoretical knowledge was significantly associated with practical skills (Padjusted=.02; r=0.13). By using the current pass mark for theoretical knowledge (ie, 60%), a significant differentiation between insufficient practical skills (<60%) and sufficient practical skills (≥60%) was achieved (P=.02). However, for the discrimination between students with sufficient practical skills and students with insufficient practical skills, an adapted pass mark for theoretical knowledge would be more appropriate. The ideal pass mark amounted to 58% (P=.02).

CONCLUSIONS

Students’ practical skills and theoretical knowledge are significantly correlated. By objectively measuring students’ theoretical knowledge, a rough estimation of students’ practical skills (ie, a differentiation between sufficient and insufficient practical skills) is possible.
A Metric of Societal Burden Based on Virus Succession to Determine Economic Losses and Health Benefits of China’s Lockdown Policies: Model Development and Validation (Preprint)
Authors: Chen Wenxiu , Zhang Bin , Wang Chen , An Wei , Guruge Shashika Kumudumali , Chui Ho-kwong , Yang Min
Published: April 2023

BACKGROUND

The COVID-19 pandemic had a profound impact on the global health system and economic structure. Although the implementation of lockdown measures achieved notable success in curbing the spread of the pandemic, it concurrently incurred substantial socioeconomic costs.

OBJECTIVE

The objective of this study was to delineate an equilibrium between the economic losses and health benefits of lockdown measures, with the aim of identifying the optimal boundary conditions for implementing these measures at various pandemic phases.

METHODS

This study used a model to estimate the half-lives of the observed case fatality rates of different strains. It was based on global infection and death data collected by the World Health Organization and strain sequence time series data provided by Nextstrain. The connection between the health benefits and economic losses brought by lockdown measures was established through the calculation of disability-adjusted life years. Taking China’s city lockdowns as an example, this study determined the cost-benefit boundary of various lockdown measures during the evolution of COVID-19.

RESULTS

The study reveals a direct proportionality between economic losses due to lockdowns and the observed case fatality rates of virus strains, a relationship that holds true irrespective of population size or per capita economic output. As SARS-CoV-2 strains evolve and population immunity shifts, there has been a notable decrease in the observed case fatality rate over time, exhibiting a half-life of roughly 8 months. This decline in fatality rates may offset the health benefits of maintaining unchanged lockdown measures, given that the resultant economic losses might exceed the health benefits.

CONCLUSIONS

The initial enforcement of lockdown in Wuhan led to significant health benefits. However, with the decline in the observed case fatality rate of the virus strains, the economic losses increasingly outweighed the health benefits. Consequently, it is essential to consistently refine and enhance lockdown strategies in accordance with the evolving fatality and infection rates of different virus strains, thereby optimizing outcomes in anticipation of future pandemics.
BİREYLERİN MOBİL SAĞLIK UYGULAMASI KULLANIM DURUMU ve E-SAĞLIK OKURYAZARLIĞI İLİŞKİSİ
Authors: KAYA Emin , EKE Erdal
Published: April 2023

Amaç: Bu çalışmanın amacı; mobil sağlık uygulamalarının kullanım sıklıklarını belirleyerek mobil sağlık uygulaması kullanımının e-Sağlık okuryazarlığıyla olan ilişkisini ortaya koymak ve kullanıcıların mobil sağlık uygulamalarını tercih nedenlerini, ihtiyaç duydukları mobil sağlık uygulamalarının neler olduğunu ve mevcut uygulamalara yönelik endişe düzeylerini belirlemektir. Yöntem: Çalışmadaki veriler Norman ve Skinner (2006) tarafından geliştirilerek Gencer (2017) tarafından Türkçe’ye uyarlanan “E-Sağlık Okuryazarlığı Ölçeği” ile toplanmıştır. Verilerin analizinde tanımlayıcı istatistik, bağımsız örneklem t testi, tek yönlü varyans analizi ve korelasyon analizi kullanılmıştır. Veriler %95 güven aralığında (p=0,05) analiz edilmiştir. Bulgular: Katılımcıların %93,51’i sağlık ihtiyaçlarını karşılamak için farklı kategorilerde mobil sağlık uygulaması kullanmayı tercih etmekte olup, e-Sağlık okuryazarlığı düzeylerinin tüm kategorilerde iyi ve genel olarak 3,76 ortalama ile yüksek seviyelerdedir. Katılımcıların yaş ve cinsiyetine göre e-sağlık okuryazarlığı düzeylerinde anlamlı fark bulunmamasına karşılık eğitim durumu ve çalışma durumlarına göre anlamlı fark bulunmaktadır. Katılımcıların yaklaşık %56’sı mobil sağlık uygulaması kullanırken veri gizliliği ve güvenliği konularında endişe duymadığını ifade ederken, %30’u kararsız olduğunu, %14’ü ise endişelendiğini belirtmektedir. Sonuç: Araştırmanın sonuçlarına göre çalışmaya katılan bireylerde mobil sağlık uygulamalarının kullanımı oldukça yaygın olup en sık tercih edilen mobil sağlık uygulamaları arasında çevrim içi randevu alma uygulamaları gelmektedir.
EXAMINATION OF THE RELATIONSHIP BETWEEN THE HEALTH LITERACY LEVEL AND HEALTH ANXIETY OF INDIVIDUALS DURING THE COVID-19 PANDEMIC
Authors: MERT Ekrem , KEKLİK Belma
Published: April 2023

Aim: This study aims to determine individuals' health literacy and anxiety levels and their relationship.
Methods: In the study, the TSOY-32 scale developed by Okyay and Abacıgil (2016) on behalf of the Ministry of Health, and the Health Anxiety Inventory (Short Version), which was translated into Turkish by Aydemir et al. (2013) for validity and reliability study, were used. The study population consists of individuals over 18 living in Isparta province. The sample size determined within the scope of the study is 384 people, and 401 participants were reached. SPSS 22 was used to analyze the collected data. Relationships between variables were examined via t-test, ANOVA analysis, correlation and regression analysis.
Results: A significant difference was observed from comparing the scores of hypersensitivity to physical symptoms and anxiety subscale of the health anxiety scale with the chronic disease/disability status and age groups of the participants. No significant correlation was found between health literacy index scores and health anxiety scores. After the regression analysis to question whether the level of health literacy is a significant determinant of individuals' health anxiety level, no significant difference was observed.
Conclusion: The health literacy index score of the participants was found to be 32.13. In literature, this result is considered a problematic/limited level of health literacy. As a solution, it may be possible to increase the general literacy level in society first and then take measures to increase health literacy by the health authorities. The health anxiety level of individuals was found to be mild. These findings show that, during the COVID-19 pandemic, health literacy does not have any effect that increases or decreases health anxiety level.
Profil Skala Nyeri dan Kadar Interleukin-6 pada Pasien Ulkus Kornea Bakteri di RS Mata “Dr. YAP” dan RSUP Dr. Sardjito Berdasarkan Profil Terapi: Prospective Case Series
Authors: Shabrina Bani Adlina , Puspitasari Ika , Pawiroranu Suhardjo
Published: April 2023

Ulkus kornea merupakan kondisi kegawatdaruratan mata yang ditandai dengan inflamasi pada kornea dan adanya infiltrat pada kornea akibat defek epitel. Penyebab utama dari ulkus kornea adalah infeksi bakteri. Case series ini bertujuan untuk mengetahui profil kadar interleukin-6 dan skala nyeri pada pasien ulkus kornea bakteri  di indonesia berdasarkan profil terapi. Penelitian ini merupakan penelitian prospektif observasional, dengan parameter berupa penurunan kadar interleukin-6 (IL-6) dan skala nyeri berdasarkan visual analogue scale (VAS). Terdapat 2 (dua) kasus ulkus kornea bakteri di Rumah Sakit Mata “Dr. YAP” and Rumah Sakit Umum Pusat Dr. Sardjito yang dibahas dalam case series ini. Kasus 1 (satu) berasal dari Rumah Sakit Mata “Dr. YAP” dan merupakan laki-laki berusia 14 tahun yang didiagnosis ulkus kornea dengan tingkat keparahan sedang, durasi penyakit selama 2 (dua) bulan, dan penyebab penyakit tidak diketahui. Kasus 2 (dua) berasal dari Rumah Sakit Umum Pusat Dr. Sardjito dan merupakan pria berusia 33 tahun yang didiagnosis ulkus kornea dengan tingkat keparahan berat, durasi penyakit selama 3 hari, dan penyebab penyakit tidak diketahui. Hasil penelitian ini menunjukkan bahwa profil terapi yang berbeda-beda tetap memberikan penurunan kadar IL-6 dan skala nyeri (VAS) pada semua kasus ulkus kornea bakteri dengan tingkat keparahan, durasi, dan penyebab penyakit masing-masing.
Potensi dan Stabilitas Emulgel Ekstrak Etanol Daun Strawberry (Fragaria x ananassa var Duchesne) Sebagai Tabir Surya
Authors: Auliya Detyari Faza , Suhartinah Suhartinah , Ansory Hery Muhamad
Published: April 2023

Ekstrak daun stroberi (Fragaria x ananassa var Duchesne) dilaporkan memiliki aktivitas tabir surya yang baik. Namun, diperlukan formulasi dosis yang sesuai untuk tahap selanjutnya. Oleh karena itu, penelitian ini bertujuan untuk memformulasi emulgel dari ekstrak etanol daun stroberi menggunakan uji sifat fisik, uji stabilitas, dan uji nilai SPF. Daun stroberi diekstraksi dengan metode refluks dengan etanol 96%. Ekstrak dianalisis kandungan kimianya dengan KLT. Emulgel diformulasikan dengan ekstrak 0,25%, 0,50%, dan 1%. Emulgel diuji sifat fisik, stabilitas, dan aktivitas tabir surya secara in vitro dan in vivo. Hasil penelitian menunjukkan bahwa rendemen ekstrak etanol daun strawberry adalah 20,5%, dan uji KLT menunjukkan kandungan positif flavonoid dan tanin. Formula emulgel yang memiliki efektivitas paling baik sebagai barrier adalah formula dengan konsentrasi ekstrak 1%. Konsentrasi ekstrak etanol 1% daun strawberry dan emulgel menghasilkan nilai SPF sebesar 59,94 ± 0,260.
Hubungan Tingkat Pengetahuan dan Kepatuhan Terhadap Luaran Klinik Pasien Diabetes Mellitus melalui Metode Brief Counseling di Puskesmas di Kabupaten Pemalang
Authors: Yasin Nanang Munif , Syafitri Irrene Wulan , Sari Ika Puspita
Published: April 2023

Pandemi COVID-19 menyebabkan terjadinya penurunan interaksi kegiatan rutin PROLANIS pasien Diabetes Mellitus  (DM) tipe 2 di fasilitas kesehatan tingkat pertama. Tujuan dari penelitian ini adalah untuk mengetahui hubungan tingkat pengetahuan dan kepatuhan terhadap luaran klinik pasien DM tipe 2 setelah pemberian brief counseling oleh apoteker. Jenis penelitian ini adalah quasi-experimental dengan metode pretest and posttest design with control group. Penelitian ini dilakukan secara prospektif untuk menganalisis hubungan tingkat pengetahuan dan kepatuhan terhadap luaran klinik pasien Diabetes Mellitus setelah pemberian brief counseling. Tingkat pengetahuan diukur menggunakan kuesioner Diabetic Knowledge Questionnaire-24 (DKQ-24), tingkat kepatuhan diukur menggunakan kuesioner Morisky Green Levine Scale (MGLS), dan luaran klinik pasien DM tipe 2 berupa glukosa darah puasa (GDP) di Puskesmas di Kabupaten Pemalang pada periode Oktober hingga November 2021. Analisis data karakteristik subjek penelitian menggunakan metode deskriptif dan disajikan dalam bentuk presentasi dan frekuensi. Analisis untuk mengetahui hubungan antara tingkat pengetahuan dan kepatuhan terhadap luaran klinik menggunakan uji chi-square dengan tingkat kepercayaan 95% (α = 0,05). Penelitian ini terdiri dari 32 pasien pada masing-masing kelompok kontrol dan intervensi. Hasil analisis deskriptif penelitian ini menunjukkan tidak terdapat perbedaan data karakteristik subjek penelitian pada kelompok kontrol dan intervensi (p>0,05).  Hasil analisis bivariat terkait korelasi menunjukkan adanya hubungan antara tingkat pengetahuan terhadap luaran klinik (p=0,000), dan tingkat kepatuhan terhadap luaran klinik pasien DM tipe 2 (p=0,000). Berdasarkan hasil penelitian tersebut, dapat disimpulkan bahwa ada hubungan yang bermakna antara tingkat pengetahuan dan kepatuhan terhadap luaran klinik pasien DM tipe 2 setelah pemberian brief counseling oleh apoteker.
ASSOCIATION OF DRUG RELATED PROBLEMS (DRPs) OCCURRENCE WITH CLINICAL OUTCOME IN ISCHEMIC STROKE PATIENTS
Authors: WARDHANI FIRDHA APRILLIA , IKAWATI ZULLIES , YASIN NANANG MUNIF
Published: April 2023

Ischemic stroke is one of the main causes of death and disability in Indonesia and in the world whose prevalence continues to increase. One of the factors that increase disability in ischemic stroke patients is poor stroke management, and the incidence of DRPs plays a role in it. This study was conducted to determine whether there is a significant relationship between the incidence of DRPs in ischemic stroke patients, and the patient's clinical outcome, which is described by the patient's NIHSS status. It is known that NIHSS is an outcome parameter with the best accuracy and sensitivity compared to other outcome parameters. The study was conducted with a retrospective cross-sectional design, involving 111 samples sourced from the medical records of patients who met the inclusion criteria in the April-October 2021 period. The DRPs analyzed in this study were medication errors, the need for additional drugs, too low drug doses, and drug side effects occur. In this study, DRPs occurred in 88.2% of patients, with the most common type being the need for additional drugs in patients. This study found that the presence of DRPs in ischemic stroke patients, has the potential to increase the risk of patients experiencing clinical outcomes that do not improve as described by the NIHSS status (OR 3,714; p-value<0,05).
Preparation of Solid Lipid Nanoparticle-Containing Ovalbumin Based Reverse Micelle-Double Emulsion Technique
Authors: Zai Khadijah
Published: April 2023

Encapsulation of protein in the lipid-based nanoparticle is quite challenging. A reverse micelle-double emulsion method could be used for answering this challenge because reverse micelles able to protect the polar core in a nonpolar solvent. Thus, the protein solution can be kept in the interior of the reverse micelle particle and hosted in a lipid matrix of nanoparticles. Herein, we describe the preparation of solid lipid nanoparticles (SLNp) for the encapsulation of ovalbumin (Ova) with reverse micelle-double emulsion. Using several combinations of solid lipids and phospholipids, we prepared SLNp containing Ova-reverse micelle. The optimized formulation enabled the incorporation of Ova in the solid lipid matrix of SLNp with nano size and narrow particle size distribution (PdI), and high entrapment efficiency for Ova. The particle size and zeta potential were measured by a dynamic light scattering spectrophotometer 214.8±15.94 nm and −3.44±0.21 mV, respectively. The entrapment efficiency (EE%) was determined by Spectrofluorometer by determining the quantitative of Ova-FITC labeling was 98.97±0.89%.
Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review
Authors: Nurani Laela Hayu , Edityaningrum Citra Ariani , Irnawati Irnawati , Putri Anggita Rosiana , Windarsih Anjar , Guntarti Any , Rohman Abdul
Published: April 2023

Spectroscopic method in the UV-Vis region is considered the most molecular spectrometric method for content determination of a single component. However, a lot of pharmaceutical dosage forms comprise two or more components which lead to peak overlapping. Moreover, in the chemical stability test, active pharmaceutical ingredient (API) was also found along with the degradation products, impurities, and adulterant compounds. UV-Vis spectroscopy is one of the methods of choice for the determination or quantification of a single component in pharmaceutical preparations. The pharmaceutical products typically contain two or more APIs having chromophoric agents capable of absorbing UV-Vis beams and the absorbance values are summative from the absorption of each UV-Vis active compound according to the additive nature of Lambert-Beer law. The main problem for the simultaneous determination of API along with impurities and the degradation products in pharmaceutical preparations is the presence of overlapping peaks of UV-Vis spectra. The chemometrics-assisted spectroscopy is one of the analytical efforts to solve these problems. This review highlighted the application of chemometrics in combination with UV-Vis spectroscopy for the assay of API, impurities, adulteration issues and degradation products present in pharmaceutical dosage forms.
Pancreatic Lipase Inhibition Activity in Lipid Absorption Using Traditional Plants: A Systematic Review and Meta-Analysis
Authors: Hasim Hasim , Faridah Didah Nur , Qomaliyah Eka Nurul , Afandi Frendy Ahmad
Published: April 2023

Obesity is a complex and multifactorial disease resulting from excessive accumulation of fat. With a significant annual increase, it has become a health concern across the globe in the last decades. To tackle this problem, an exploration of traditional medicinal plants (TMP) functioning as anti-obesity drugs using an ethnopharmacology approach has been carried out. Research on the drug development of obesity treatment was directed at how to inhibit pancreatic lipase as the enzyme accounted for lipid absorption. Using a systematic review and meta-analysis, this current study investigated TMP anti-obesity from the articles published in 6 scientific databases, i.e., Scopus, Science Direct, Proquest, Cengage Library, Ebsco, and Emerald, using particular keywords. The review resulted in 19 articles containing 91 eligible data based on inclusive and exclusive criteria. Meta-analysis extracted data as follows: IC50, number of replications, and standard error, regarding the anti-obesity effects of medicinal plants and orlistat as a positive control. The results showed 8 medicinal plants showing anti-obesity via inhibition of pancreatic lipase, including Solenostemma argel, Garcinia vilersiana, Phyllanthus chamaepeuce, Cassia auriculata, Moringa oleifera, Ficus carica, Ocimum gratissimum, and Adiantum capillus-veneris.
Characterization and Antibacterial Activity Assessment of Hydroxyapatite-Betel Leaf Extract Formulation against Streptococcus mutans In Vitro and In Vivo
Authors: Muhaimin Fitriari Izzatunnisa , Cahyaningrum Sari Edi , Lawarti Riska Amelia , Maharani Dina Kartika
Published: April 2023

Hydroxyapatite is an inorganic material that is commonly used as a re-mineralizing agent. Adding natural ingredients such as green betel leaf can increase the antibacterial properties due to the presence of phenolic compounds, flavonoids, and tannins. This study aims to determine the physical and chemical characteristics of the formulation of hydroxyapatite-betel leaf extract and the antibacterial activity against Streptococcus mutans. To characterize the combination of hydroxyapatite-betel leaf extract, XRD, PSA and FTIR analyses were performed. Particle size analysis showed the smallest results in the variation of betel 0.3 g, which is 690.08 nm. FTIR characterization showed the presence of OH, PO43− and CO32− functional groups from hydroxyapatite and C=O derived from betel leaf extract. In addition, in vitro and in vivo analyses were performed to assess the antibacterial activity of this formulation. The in vitro antibacterial activity test against S. mutans showed strong inhibitory activity. Our finding suggests that the formulation has the potential to be used as a medication or prevention agent for dental caries.
The Stability Study of Electrochemical Aptasensor to Detect SARS-CoV-2 Spike Protein and Its Application for Clinical Samples of Nasopharyngeal Swab
Authors: Sari Arum Kurnia , Fadhilah Ghina Nur , Irkham Irkham , Yusuf Muhammad , Gaffar Shabarni , Hartati Yeni Wahyuni
Published: April 2023

The stability characteristics associated with the shelf life of a biosensor are rarely investigated, however, they are important factors for real applications. Stability is the variation in the detection signal over a long period of storage. This study aims to determine the effect of storage time on the stability of SARS-CoV-2 receptor binding domain (RBD) spike protein aptamers related to shelf life and the performance of an electrochemical aptasensor on clinical samples. The research method includes a stability study conducted using the accelerated stability method based on the Arrhenius equation at three variations of temperature and storage time. The electrochemical aptasensor's performance was evaluated on clinical samples of 32 nasopharyngeal swabs at biosafety level 3 and its potential on clinical saliva samples. The results indicated that the developed electrochemical aptasensor was stable for ± 15 days with a shelf life of 18, 17 and 16 days, respectively, at 25, 40 and 50 °C. This electrochemical aptasensor has the potential to be a Point of Care (POC) device for the clinical detection of SARS-CoV-2 because it can be tested on clinical samples of nasopharyngeal swabs and the results show its potential application to detect in clinical saliva samples.
Polyvinylidene Fluoride (PVDF)/Modified Clay Hybrid Membrane for Humic Acid and Methylene Blue Filtration
Authors: Pramono Edi , Sejati Gadis Prihatin Wahyu , Wahyuningsih Sayekti , Purnawan Candra
Published: April 2023

This research studied the impact of silanized clay modification on performance and antifouling Poly(vinylidene fluoride) (PVDF) membrane toward humic acid and methylene blue filtration. Clay modification was carried out by using 3-aminopropyltriethoxysilane (APS) to produce modified clay (Clay-APS). Hybrid membranes were prepared by phase inversion for humic acid and methylene blue filtration. Hybrid membranes were characterized by measuring surface hydrophilicity, water flux, rejection, and antifouling properties. Clay and Clay-APS modification increased hybrid membrane surface hydrophilicity, as indicated by increasing the β fraction and decreasing the water contact angle. The PVDF/Clay and PVDF/Clay-APS hybrid membranes showed high permeability and selectivity with the highest water flux values of 24.2 L m−2 h−1. The rejections for humic acid and methylene blue were 98.8 and 99.3%, respectively. The highest antifouling property was obtained from the PVDF/Clay-APS hybrid membrane, with a flux recovery ratio was 96.0%. The PVDF/Clay hybrid membrane performance and antifouling properties showed that the membranes have the potential for water treatment.
Indonesian Purple Rice Ferulic Acid as a Candidate for Anti-aging through the Inhibition of Collagenase and Tyrosinase Activities
Authors: Wijayanti Ernanin Dyah , Safitri Anna , Siswanto Dian , Fatchiyah Fatchiyah
Published: April 2023

Skin aging is associated with decreased skin firmness and excessive pigmentation, which is caused by the activity of aging enzymes. This process can be prevented with powerful antioxidants from nature, such as ferulic acid which is abundant in rice. This study examines the nutritional content and phytochemicals of Indonesian purple rice and evaluates the bioactivity of ferulic acid as an anti-aging agent. Indonesian purple rice has less fat than black and white rice, more amino acids involved in aging regulation, and a similar phytochemical profile to black and white rice. Indonesian purple rice has a lower concentration of ferulic acid (4.114 ± 0.013 mg/L) than black rice but shows strong reducing power (IC50 9.35 ± 1.95 µg/mL), high anti-tyrosinase (IC50 59.57 ± 3.60 µg/mL), and moderate anti-collagenase activities (IC50 74.18 ± 3.11 µg/mL). This study supports the use of Indonesian purple rice as a promising active ingredient in natural anti-aging cosmetics.
Calcium Phosphate Cement Composed of Hydroxyapatite Modified Silica and Polyeugenol as a Bone Filler Material
Authors: Windarti Tri , Prasetya Nor Basid Adiwibawa , Ngadiwiyana Ngadiwiyana , Nulandaya Limpat
Published: April 2023

A composite of hydroxyapatite modified silica (HASiO2) and 10% (w/w) polyeugenol (PE) was synthesized to produce a calcium phosphate cement with antibacterial activity. The compatibility of the composite (HASiO2_PE) with bone filler requirements was determined due to its crystal, surface, antibacterial, and cytocompatibility properties. The results showed that compositing HASiO2 and PE did not affect HA's chemical dan crystal properties. The presence of PE changed HASiO2 morphology to be coarser and denser than before composited. PE tends to agglomerate but does not affect the hydrophilicity of HASiO2. The presence of PE increased the surface area and total pore volume but lowered the average pore size. Different from pure PE, the composite of HASiO2_PE that contains of 10% PE has higher antibacterial activity toward Escherichia coli than Staphylococcus aureus. The composite is biocompatible because the cytotoxicity test toward pre-osteoblast cells resulted in an IC50 of 2092 μg/mL. Thus, due to its chemical, surface, antibacterial, and cytocompatibility properties, the HASiO2_PE composite can be recommended as a bone filler material.
Hacer hogar fuera del closet: disputando el espacio doméstico en Santiago de Chile
Authors: Besoain Arrau Carolina , Ojeda Güemes Tomás , Rihm Bianchi Andrea Isabel
Published: April 2023

Los vínculos entre hogar, género y sexualidades no normativas han recibido poca atención académica en Chile. En este artículo analizamos discursos, prácticas e imaginarios acerca del hogar en dos hombres gays y una mujer lesbiana de la comuna de Peñalolén, Santiago de Chile, desde una perspectiva biográfica y feminista. Se presentan cuatro dimensiones transversales: 1) hacer hogar como lucha por la apropiación, 2) hogar como un espacio paradojal y de negociación con la norma heterosexual, 3) roles de género y distribución del trabajo doméstico, y 4) relación con el espacio extradoméstico y los imaginarios gays y lésbicos locales. Estas dimensiones muestran que el hogar es un espacio conflictivo donde conviven sentidos en disputa que deben comprenderse de manera dinámica, situada e interseccional.
Situación de espera, burocracia y acceso a la protección legal: el caso de las personas migrantes por la frontera sur de México
Authors: Rosales Cervantes Guillermo
Published: April 2023

Los obstáculos para el acceso a la justicia y la protección de los derechos de las personas migrantes aumentan en México. Estos son producto de un entramado de disposiciones globales, regionales y locales, así como de una situación de espera en la que se expresan prácticas burocráticas y mecanismos disciplinarios de la voluntad humana. En este artículo se busca dar cuenta de cómo la intersección entre estos elementos produce una concepción oscilante de justicia, autoridad y paciencia, que no aparta a las personas de su búsqueda por protección legal y que a la par tensiona la noción de ilegalidad que se construyen sobre su condición migratoria y su actuar. Los resultados muestran que una manera de confrontar a la autoridad y hacer manifiesta la capacidad de agencia es a través del derecho al repliegue. Este recurso permite construir una base política que permite subvertir la lógica estatal de la exterioridad y, en paralelo, evidencia la necesidad de establecer relaciones solidarias amplias para cumplir objetivos.
D-Drive: Decentralized Storage Space using Blockchain and IPFS Protocol
Authors: Shinde Smita
Published: April 2023

Abstract: Centralized cloud-based storage has received great attention and has been extensively used by many companies in recent years. However, these cloud based storage are not secure because of the involvement of a centralized entity or a third party. On the other hand, there is a need for blockchain based decentralized storage to maximize data privacy and security. This paper proposed D-Drive, an IPFS-based decentralized storage space to solve the problem. D-Drive is a software solution trying to prove that centralized cloud-based storage applications can be decentralized, more secure, and efficient. This paper proposed developing a web-based application that provides a user interface,from which the user can directly share their data or files. Then, the user file is encrypted and stored across a peer-to-peer network using IPFS protocol instead of HTTP protocol and a cryptocurrency will be used as a payment mechanism. D-Drive’s primary objective is to provide secure decentralized storage space.
Tendencias emergentes de investigación científica sobre Dactylopius coccus Costa (Hemiptera: dactylopiidae), ácido carmínico y sus derivados: un análisis bibliométrico.
Authors: Bravo Vinaja Ángel , Méndez Gallegos Santiago de Jesús
Published: April 2023

El objetivo del estudio fue identificar las temáticas emergentes de la producción científica publicada en revis­tas de corriente principal, su visibilidad y sinergias a través de un enfoque de indicadores bibliométricos (IB) unidimensionales y multidimensionales sobre Dactylopius coccus, ácido carmínico (AC) y derivados, de 1980 a 2019. Los IB se obtuvieron con los programas informáticos Excel®, bibliometrix, y VOSviewer. Durante el periodo en estudio se registró un crecimiento de las publicaciones en el cual predominaron los artículos científicos en inglés, concentrados en dos revistas: Food Chemistry y Journal of Raman Spectroscopy. I. Karapanagiotis resultó el autor con la productividad más alta; los autores con mayor influencia en la generación de nuevo conocimiento fueron M. Leona (576 citas) y F. Casadio (568 citas) ambos de los Estados Unidos de América (EE. UU.). La investigación principal se orientó a la identificación, caracterización y análisis del AC con diferentes técnicas. Otras temáticas emergentes e innovadoras destacadas fueron la aplicación del AC en celdas solares, y sus propiedades terapéuticas como antioxidante y para prevención de cáncer. Algunos de los temas recurrentes se relacionaron con aspectos biológicos del insecto, los efectos secundarios asociados con el consumo o exposición al AC, a la tinción de fibras naturales o animales y a sus aplicaciones como aditivo alimentario.
EFFECTS OF PLANTING POSITION AND Azospirillum brasilense APPLICATION ON THE SPROUT AND AGRONOMIC TRAITS OF CASSAVA (Manihot esculenta Crantz)
Authors: Peñuelas Rubio Ofelda , Argentel Martínez Leandris , Gonzalez Aguilera Jorge , Krewer Bruna Izabel , Ferrerira Diniz Jessica , Vilela Barros Pedro Paulo , Alfonso Junior José Aristeu , Ratke Rafael Felippe , Zuffo Alan Mario , Garatuza Payán Jaime
Published: April 2023

The present work aimed to evaluate the effect of the seedling position and Azospirillum brasilense application on the initial development of cassava. The assay was conduced following a completely randomized experimental design, with factorial arrangement (planting positions [horizontal (HP) and vertical (PV)] and the A. brasilense [with (+Azos) and without (-Azos)]). The sprouting percentage (SP) was evaluated from 11 to 35 days after planting (DAP). After 30 DAP, the following variables were evaluated: sprouts number (SN), sprouts height (SH), number of leaflets (NL), length of leaflets (LL), and vegetative vigor (VV). Cassava plants positioning significantly influenced the initial growth. PV promotes a greater sprouting, 63% in 17 DAP, over the PH which was only 3% of the visible shoots during the same period. Here we show for the first time that PV promoted the highest values â€‹â€‹combined with -Azos in the variables SH (an increase of 17%) and VV (an increase of 61%). The PH, in combination with +Azos, stimulated the NL in 20%. The sub-division into three VV groups allowed identify the existence of differences among the treatments which were not seen in an independent ANOVA being VV an important variable for the initial growth evaluation in cassava.
Социально-пространственная организация гигиенических процессов в жилой ячейке
Authors: Матвеев Дмитрий , Евгений Орлов
Published: April 2023

В статье рассматриваются вопросы, связанные с улучшением организации различных видов санитарно­гигиенических процессов в жилой ячейке. Выяснено, что сегодня помещениям, где проводятся гигиенические процедуры, уделяют мало внимания при организации проектирования. Это связано прежде всего с тем, что не учитывают специфику проживания на площади жилой ячейки сложных и крупных семей, предлагая однообразные решения в области про­ектирования санитарно-технических узлов. Предложены решения по выделению новых типов санитарных помещений внутри жилой ячейки: санитарно-гигиенического узла, санитарно-постирочного узла и санитарно-оздоровительного узла, проектирование которых ведёт к улучшению гигиенического комфорта. Это также приводит к повышению качества жизни, значительно влияя на другие процессы жизнедеятельности. Дана информация по размещению на площадях таких помещений рекомендованного оборудования.
Health of Roma People living in marginalized Communities in Slovakia
Authors: Ludvigh Cintulova Lucia , Budayova Zuzana , Juhasova Ingrid
Published: April 2023

Introduction. The biggest Roma communities reside in the eastern part of Slovakia in the regions of Presov and Kosice, whose share is 35-40%. While the atlas of Roma communities from 2019 indicates that about 440,000 Roma live in Slovakia, only 156,000 Roma registered in 2021. Moreover, more than half of them stated Roma nationality only as a second nationality. Due to the fear of discrimination, racism and hate speech 10-15% of Roma did not state their identity because they consider it more advantageous in their efforts to integrate into society. It is also assumed that a significant part of the Roma (12- 15%) living in the south of Slovakia have adopted the Hungarian nationality. Objectives. The main goal was to map and analyse the development of civilizational and infectious diseases in the Roma population, taking into account the social, economic and cultural status of the Roma in Slovakia. Methods: The data were analysed on the basis of available statistics and forecasts of the development of diseases in the allSlovak databases maintained by the NCZI SR and the Statistical Office of Slovak Republic. We compared the development of tuberculosis, hepatitis, diabetes, and the overuse of psychotropic substances, which often occur in marginalized Roma communities. Results: The results showed that although some diseases such as tuberculosis and hepatitis are decreasing along with the general average of registered diseases in the population, their highest occurrence in terms of the number of registered cases still occurs in Roma communities. Among Roma, the proportion of people addicted to psychotropic substances is increasing, the risk of infectious and civilizational diseases such as e.g. diabetes, asthma, obesity and cardiovascular diseases. Conclusion. With the decreasing quality of life of the Roma, the number of infectious and civilizational diseases also increases, therefore we recommend that comprehensive prevention, education in the field of vaccination and support for early diagnosis of diseases be implemented.
Developing and addressing Socio-pathological Phenomena in Children, Adolescents and young Adults in marginalised Environments
Authors: Turner Jon , Turner Troya
Published: April 2023

The theme of this issue of CSW is Developing and addressing socio-pathological phenomena in children, adolescents and young adults in marginalized environments. Thisis a profoundly important concept affecting not just the indicated marginalized but all young people. In this age of digital & internet communications it means that younger & lonelier young people using texting on their telephones as their main contact with the world being damaged. Because texting means monumentally less person-to-person contact, society is losing respect and kindness to and from others leading to disrespect and anti-social pathological behaviors