bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation Criteria and Algorithm for Calculating the Environmental Quality Index of Rural Areas
Authors: Lavrentieva I. V. , Javakhia V. V. , Sedova N. V.
Published: July 2022

In the context  of the implementation of the state program for the integrated  development of rural areas, the issue of assessing the quality  of the environment  of rural areas remains particularly  relevant  in order to determine  priority areas of development  and allocation  of budget  funds.  Until  now, there  was  no such  methodology, at the  same  time  there  was  a methodology  for assessing the  quality  of the  urban  environment, which  is not  applicable in rural territories,  since it does not take  into account  the specifics of their development. The  article presents a methodology  for calculating  the quality  of rural areas. The  authors emphasize  in their research the relevance of the development  of this methodology, as it will allow to assess the quality of rural areas and on its basis to propose directions for improving the policy of state regulation  within  the framework  of existing regulatory legal acts.  The authors identified the key areas of rural environment  development, 11 assessment groups and the assessment is carried out by 30 indicators for each object of assessment. A point system has been developed  for the transition  from absolute values of indicators  by indicators  to a single calculation  system.  As part of the assessment, integral indices are also formed  that allow assessing the quality of the environment  at the level of the whole country, individual regions, municipalities  and settlements.  At each level of assessment, it is possible to identify key areas of improvement, work in which  will ensure maximum effect for the growth of the quality of the rural environment  at various levels of management.
Characterization of Pili Protein 67 kDa Streptococcus pneumoniae: New
Candidate for Virulence Factor-Based Pneumococcal Antigen Vaccine
Authors: Mufida Diana C. , Perwitasari Rahma , Agustina Dini , Shodikin Muhammad A. , Suswati Enny
Published: July 2022

Introduction:

Streptococcus pneumoniae is a Gram-positive diplococci bacteria that cause infectious diseases such as otitis, meningitis, and pneumonia. Streptococcus pneumoniae has various virulence factors, one of which is pilus. In addition to being immunogenic, pilus S. pneumoniae also plays a role in bacterial adhesion to host cells and biofilm formation. The S. pneumoniae pilus found in this study consisted of several proteins with various molecular weights, one of which was a 67 kDa protein. Objective: This study aimed to determine the characteristics of the 67 kDa pilus protein, including Its ability as hemagglutinin and adhesin and its amino acid composition (AA).

Methods:

The LCMS/MS method is used to determine the AA composition of the 67 kDa pilus protein. The AA structure was analyzed through BLASTP by matching it with the sequence of the protein data bank of S. pneumoniae (taxid: 1313). The Protparam tool from ExPASy is used to calculate various physical and chemical parameters of the protein, while for evaluating its immunogenicity, it uses the VaxiJen V2.0 online server.

Results:

The results of this study indicate that the 67 kDa pilus protein is an anti-hemagglutinin protein and has a role as an adhesin protein. Adhesion tests show the action between protein concentration and the number of bacteria attached to enterocyte cells. LCMS/MS test results continued by BLASTP showed that the 67 kDa pilus protein had three AA sequences (ITYMSPDFAAPTLAGLDDATK, AEFVEVTK, and LVVSTQTALA), which had similarities with the A backbone chain of S. pneumoniae pilus. The physicochemical test shows that the protein is hydrophilic and nonpolar, while the antigenicity test shows that the protein is antigenic.

Conclusion:

Based on these characteristics, it can be concluded that the 67 kDa S. pneumoniae pilus protein can be used as a vaccine candidate for pneumococcus.
Mesenchymal Stem Cell Therapy for ALI/ARDS: Therapeutic Potential and
Challenges
Authors: Wang Zhenxing , Yu Tong , Hou Yapeng , Zhou Wei , Ding Yan , Nie Hongguang
Published: July 2022

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious clinical common disease, which may be caused by a variety of pathological factors and can induce a series of serious complications. There is still no specific and effective method for the treatment of ALI/ARDS. Mesenchymal stem cells (MSCs) have been one of the treatment methods for ALI, which can regulate related signal pathways such as PI3K/AKT, Wnt, and NF-κB to reduce inflammation. MSCs exist in a variety of tissues and have the ability of self-renewal and differentiation, which can be activated by specific substances or environments and home to the site of tissue damage, where they differentiate into new tissue cells and repair the damage. Both exosomes and cytokines involving the paracrine mechanism of MSCs have benefits on the treatment of ALI. Lung organoids produced by 3D culture technology can simulate the characteristics of the lung and help to research the pathophysiological process of ALI. This review summarizes the mechanisms by which MSCs treat ALI/ARDS and expects to use 3D models for future challenges in this field.
WITHDRAWN: Prognostic Values of COL4As Transcriptional Expressions in Clear Cell Renal Cell Carcinoma Patients
Authors: Tu Bizhi , Zhang Yiqun , Jia Yaya , Wei Laifu , Gao Fei , Sha Qi , Qian Jun
Published: July 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn from the journal "Combinatorial Chemistry & High Throughput Screening".

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

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of their article is transferred to the publishers if and when the article is accepted for publication.
U-Shaped Association Between Serum Uric Acid and Hemorrhagic Transformation
After Intravenous Thrombolysis
Authors: Chen Hongfang , Han Zhao , Cheng Zicheng , Zhan Zhenxiang , Fu Yaming , Zhang Wen Yuan , Xia Lingfan , Xu Tong
Published: July 2022

Background:

Uric acid (UA) has both antioxidative and pro-oxidative properties. The
study aimed to investigate the relationship between serum UA and hemorrhagic transformation (HT)
after intravenous thrombolysis in patients with acute ischemic stroke.

Methods:

The patients undergoing intravenous thrombolysis from two hospitals in China were retrospectively
analyzed. HT was evaluated using computed tomography images reviewed within 24-
36h after thrombolysis. Symptomatic intracranial hemorrhage (sICH) was defined as HT accompanied
by worsening neurological function. Multivariate logistic regression and spline regression
models were performed to explore the relationship between serum UA levels and the risk of HT and
sICH.

Results:

Among 503 included patients, 60 (11.9%) were diagnosed with HT and 22 (4.4%) developed
sICH. Patients with HT had significant lower serum UA levels than those without HT (245
[214-325 vs. 312 [256-370] μmol/L, p < 0.001). Multivariable logistic regression analysis indicated
that patients with higher serum UA levels had a lower risk of HT (OR per 10-μmol/L increase 0.96,
95%CI 0.92–0.99, p = 0.015). Furthermore, multiple-adjusted spline regression models showed a Ushaped
association between serum UA levels and HT (p < 0.001 for non-linearity). Similar results
were present between serum UA and sICH. Restricted cubic spline models predicted the lowest risk
of HT and sICH when the serum UA levels were 386μmol/L.

Conclusion:

The data show the U-shaped relationship between serum UA levels and the risk of HT
and sICH after intravenous thrombolysis.
Prediction of Symptoms on Admission with Early Neurological Deterioration
in Single Small Subcortical Infarct
Authors: Gao Yuan , Zong Ce , Liu Hongbing , Zhang Ke , Yang Hongxun , Wang Anran , Wang Yunchao , Zhu Hanghang , Li Yapeng , Liu Kai , Song Bo , Xu Yuming
Published: July 2022

Background:

Early neurological deterioration (END) often occurs during hospitalization
in single small subcortical infarct (SSSI). While, symptoms on admission were rarely reported about
its performance on predicting the risk of END.

Objectives:

The objective of this study is to explore the relationship between symptoms on admission
and END in SSSI.

Methods:

Patients with SSSI in the lenticulostriate artery (LSA) territory presenting within 72 hours
of stroke onset were screened prospectively. Clinical characteristics, including symptoms on admission,
laboratory tests and imaging findings, were collected. Based on the body regions involved
including spherical face (SF), upper limb (UL) or lower limb (LL), symptoms on admission were
classified into single spherical face (sSF) and any involvement of limbs (AL). END was defined as
≥2 points increase in total National Institutes of Health Stroke Scale (NIHSS) score or ≥ 1 point
increase in motor score within 72 hours after admission. Multivariate logistic regression was used to
analyze factors associated with END.

Results:

Out of 5,832 ischemic stroke patients in the database, 394 patients were finally enrolled in
analysis. 65 patients (16.5%) developed END. Multivariable logistic regression revealed that symptoms
with LL (OR 2.337, 95% CI 1.041-5.246), UL (OR 2.936, 95% CI 1.349-6.390) were both
associated with END, while the involvement of SF (OR 0.447, 95% CI 0.249-0.804) showed the
opposite result. Further analysis found that symptoms with AL (OR 3.958, 95% CI 1.355-11.565)
showed a higher risk of END compared to sSF after adjustment.

Conclusion:

Our results discovered that symptoms with AL carried a higher risk of END than those
involving sSF in SSSI.
What Happens in TBI? A Wide Talk on Animal Models and Future Perspective
Authors: Kundu Satyabrata , Singh Shamsher
Published: July 2022

Traumatic brain injury (TBI) is a global healthcare concern and a leading cause of death.
The most common causes of TBI include road accidents, sports injuries, violence in warzones, and
falls. TBI induces neuronal cell death independent of age, gender, and genetic background. TBI survivor
patients often experience long-term behavioral changes like cognitive and emotional changes. TBI
affects social activity, reducing the quality and duration of life. Over the last 40 years, several rodent
models have been developed to mimic different clinical outcomes of human TBI for a better understanding
of pathophysiology and to check the efficacy of drugs used for TBI. However, promising
neuroprotective approaches that have been used preclinically have been found to be less beneficial in
clinical trials. So, there is an urgent need to find a suitable animal model for establishing a new therapeutic
intervention useful for TBI. In this review, we have demonstrated the etiology of TBI and post-
TBI social life alteration, and also discussed various preclinical TBI models of rodents, zebrafish, and
drosophila.
Comparative Analysis of the Pre- and Post-Medication Effects of Antipsychotic Agents on the Blood-Based Oxidative Stress Biomarkers in Patients with Schizophrenia: A Meta-Analysis
Authors: Yang Mi , Wang Chunzhi , Zhao Guocheng , Kong Di , Liu Liju , Yuan Shuai , Chen Wei , Feng Can , Li Zezhi
Published: July 2022

Objectives:

Studies have shown that oxidative stress (OS) is related to the pathophysiology of schizophrenia (SCZ), but whether antipsychotics can induce OS has not been investigated well. Moreover, antipsychotics have differential effects on the OS level modulation, i.e., different types of antipsychotics have different effects on the cellular antioxidants or pro-oxidants.

Methods:

We followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines and investigated the OS indicators including both enzymatic and nonenzymatic markers, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA), glutathione (GSH), vitamin C, etc., of SCZ patients at baseline and follow-up of mono-medication.

Results:

Twenty studies met the inclusion criteria, with a total of 1162 patients enrolled at baseline, and 1105 patients completed the follow-up. OS markers were changed after a period of antipsychotic treatment in SCZ patients. The GPx activity and MDA level decreased in the whole blood (P<0.05), also the serum MDA level decreased (P<0.05). For the first-episode SCZ patients, the activity of GPx and the level of MDA decreased, while the level of vitamin C increased (all P<0.05). The levels of MDA in patients receiving atypical antipsychotics decreased (P<0.05), while the level of GSH in patients with typical antipsychotics decreased (P=0.05).

Conclusion:

Antipsychotic medication may cause changes in the levels of OS markers in different blood samples of SCZ patients. However, the available studies might not be sufficient to reveal the underlying facts accurately due to the poor quality of experimental designs in the published literature.
Epilepsy and Cognitive Impairment in Childhood and Adolescence: A
Mini-Review
Authors: Operto Francesca Felicia , Pastorino Grazia Maria Giovanna , Viggiano Andrea , Dell'Isola Giovanni Battista , Dini Gianluca , Verrotti Alberto , Coppola Giangennaro
Published: July 2022

Managing epilepsy in people with an intellectual disability remains a therapeutic challenge
and must take into account additional issues such as diagnostic difficulties and frequent drug
resistance. Advances in genomic technologies improved our understanding of epilepsy and raised
the possibility to develop patients-tailored treatments acting on the key molecular mechanisms involved
in the development of the disease. In addition to conventional antiseizure medications
(ASMs), ketogenic diet, hormone therapy and epilepsy surgery play an important role, especially in
cases of drugresistance. This review aims to provide a comprehensive overview of the mainfactors
influencing cognition in children and adolescents with epilepsy and the main therapeutic options
available for the epilepsies associated with intellectual disability.
Antimicrobial Activities of Substituted 4-N-alkylated-2-trifluoromethylquinoline
Analogs Against Nontuberculous Mycobacteria
Authors: da Silva Emerson Teixeira , de Andrade Gabriel Fernandes , Silva Lourenço Maria Cristina , de Souza Marcus Vinícius Nora
Published: July 2022

Background:

Many contagious diseases have been caused by a variety of nontuberculous mycobacteria,
opportunistic pathogens that can cause disseminated or localized diseases, particularly pulmonary,
skin, and soft tissue infections.

Objective:

In this study fifty-five substituted 4-N-alkylated-2-trifluoromethylquinolines were evaluated
against five species of nontuberculous mycobacteria: Mycobacterium fortuitum, Mycobacterium chelonae,
Mycobacterium abscessus, Mycobacterium kansasii, and Mycobacterium avium.

Methods:

The antimycobacterial activities of all tested compounds were assessed using the microplate
procedure with broth microdilution assay. The most actives were selected for their potential cytotoxic
activity against Vero cells.

Results:

Most of the compounds displayed some activity against M. kansaii, of which 12, 15, 34, 37 and
48 were the most active at 3.12 μg/mL. The derivative 8 was the most active against M. fortuitum at 6.25
μg/mL and the most active against M. chelonae at 3.12 μg/mL. The derivative 2 was the most active
against M. avium at 12.5 μg/mL, and 9 the most active against M. abscessus at 12.5 μg/mL. All the most
active compounds showed MIC values similar to the references drugs used against these species.

Conclusion:

47 compounds displayed some activity against some of the species analyzed, highlighting
derivatives 12, 15, 34, 37, and 48, which presented the lower MIC values. Compounds 34 and 37 displayed
the highest activity and did not show cytotoxicity against Vero cells. These findings have opened
new perspectives for the research of new drugs against these mycobacterial species based on the quinoline
nucleus.
In Vitro Inhibitory Effects of Agarwood Tea (Aquilaria malaccensis Lamk) Aqueous Extract on Human Cytochrome P450 (CYP) Enzyme Activities
Authors: Yan Pan , Tze Ung Yee , Jagadish Premika A P R , Hon Lim Kuan , Chowdhury Lamia Noushin Sadeque , Tao Shang , Eng Ong Chin
Published: July 2022

Background:

Agarwood tea derived from Aquilaria malaccensis Lamk is becoming an increasingly popular herbal drink that is said to have multiple health benefits. Co-administration of this tea and clinical used drugs is possible, but it increases the risk of drug-herb interactions.

Objectives:

This in vitro study investigated the inhibitory effects of agarwood tea aqueous extract on the eight major human drug-metabolising cytochrome P450 (CYP) enzyme activities.

Methods:

High-throughput fluorescence-based Vivid® CYP450 screening kits were employed to obtain the enzyme activities before and after incubation with agarwood tea aqueous extract.

Results:

Agarwood aqueous extract potently inhibited CYP2C9, CYP2D6, and CYP3A4 activities with Ki values of 5.1, 34.5, and 20.3μg/ml, respectively. The most likely inhibition mode responsible for these inhibitions was non-competitive inhibition. On the other hand, at 1000μg/ml, agarwood tea aqueous extract negligibly inhibited CYP1A2, CYP2B6, CYP2C19, CYP2E1, and CYP3A5 activities.

Conclusion:

These findings can be used to design additional in vitro investigations using clinical relevant drug substrates for CYP2C9, CYP2D6, and CYP3A4. Subsequently, future studies can be conducted to determine potential interactions between agarwood tea aqueous extract and CYP using in vivo models.
Differential Drug Release Kinetics from Paclitaxel-Loaded Polydioxanone
Membranes and Capsules
Authors: Padmakumar Smrithi , Varghese Merin Mary , Menon Deepthy
Published: July 2022

Background:

Drug laden implantable systems can provide drug release over several hours
to years, which eventually aid in the therapy of both acute and chronic diseases. The present study focuses
on a fundamental evaluation of the influence of implant properties such as morphology, architecture,
porosity, surface area, and wettability in regulating the drug release kinetics from drug-loaded
polymeric matrices.

Methods:

For this, Polydioxanone (PDS) was selected as the polymer and Paclitaxel (Ptx) as the model
drug. Two different forms of the matrix implants, viz., reservoir type capsules developed by dip
coating and matrix type membranes fabricated by phase inversion and electrospinning, were utilized
for the study. Drug release from all the four different matrices prepared by simple techniques was
evaluated in vitro in PBS and ex vivo in peritoneal wash fluid for ~4 weeks. The drug release profiles
were thereafter correlated with the physicochemical parameters of the polymeric implants.

Results:

Reservoir-type capsules followed a slow and steady zero-order kinetics, while matrix-type
electrospun and phase inversion membranes displayed typical biphasic kinetics.

Conclusion:

It was inferred that the slow degradation rate of PDS polymer as well as the implant
properties like porosity and wettability play an important role in controlling the drug release rates.
A Systematic Review of Various In-vivo Screening Models as well as the
Mechanisms Involved in Parkinson's Disease Screening Procedures
Authors: Wal Ankita , Wal Pranay , Vig Himangi , Samad Abdul , Khandai Madhusmruti , Tyagi Sachin
Published: July 2022

Background:

Parkinson's disease is the second most common neurological ailment. It is also
known that it affects practically all other brain components, although only gradually. Animal models
are mostly used to test the efficacy of treatment against a specific enzyme and aid in creating a new
drug dose.

Objective:

The purpose of this review is to highlight in vivo Parkinson's disease screening approaches,
as well as the mechanism of action of each drug involved in Parkinson's disease development, and discuss
the limitations of each model. In addition, it also sheds light on Parkinson's disease genetic models.

Methods:

The data for the publication was gathered from databases, such as PubMed, Bentham Science,
Elsevier, Springer Nature, Wiley, and Research Gate, after a thorough examination of diverse
research findings linked to Parkinson’s disease and its screening models.

Results:

Each chemical or drug has a unique mechanism for causing disease, whether through the production
of reactive oxygen species or the blockage of the dopamine receptor. Almost every disease
symptom, whether physical or behavioral, is covered by each of the constructed models' unique set of
indicators and symptoms.

Conclusion:

Animal models are typically used to assess a medicine's activity against a specific enzyme
and aid in the creation of a new drug dose. The process, restrictions, and mechanisms interfering
with the screening, as well as the level of animal suffering, must all be thoroughly reviewed before
any model for screening for Parkinson's disease can be implemented.
From self-affirmation to national security threat
Authors: Nizovtsev Yuriy Yu. , Lyseiuk Andrii M. , Kelman Mykhailo
Published: July 2022

This paper aims to study the main stages of cyberattacks’ evolution in terms of the danger they pose, from the first hooligan cyberattacks to modern cyberwars. The authors use empirical qualitative and quantitative research methods to assess the stages of cyberattack development, considering their increasing numbers, diversity, and the creation of the malware employed. The paper provides a better understanding of the causes, conditions, and consequences of the emerging types of cyberattacks. The article concludes by pointing out the three stages in the evolution of cyberattacks and draws upon the main characteristic features of the current state of the cyber environment.
Examining how Ethics in Relation to Health Technology is Described in the Research Literature: Scoping Review
Authors: Steerling Emilie , Houston Rebecca , Gietzen Luke J , Ogilvie Sarah J , de Ruiter Hans-Peter , Nygren Jens M
Published: July 2022

Background

Given the increased use of technology in health care, both in extent and application, the importance of understanding the ethical implications of new health technologies increases. Profound insight into the possible ethical implications of new health technologies enhances the research and development of such technologies and the likelihood of eventual successful implementation in clinical practice.

Objective

This study aimed to gain an understanding of how and if researchers focused on health technologies describe the actual or possible ethical aspects of their research findings.

Methods

An established framework for scoping reviews was used to guide the methodology. Studies published in PubMed over the last 10 years were included if they study or refer to ethics in relation to health technology as defined by established frameworks. In total, 14,532 articles were screened, 692 were retained for full-text evaluation, and 227 were included for data extraction.

Results

In total, 250 (80.9%, N=309) studies were conducted in North America and Europe; literature review studies were dominant. Most studies (52.9%, 120/227) had no direct reference to any of the 4 basic ethical principles: beneficence, nonmaleficence, autonomy, and justice. In cases where studies referenced ethical theory, consequentialism dominated.

Conclusions

When research about technology and ethics is published, the predominant focus is on its intent rather than its actual effect on patients. This lack of insight is problematic considering the vast advancement of technology in which ethics cannot keep up with understanding and offer insights on addressing ethical issues. This finding has implications for practice, research, and education.
Awareness, Acceptability, and Perceived Effectiveness of Text-Based Therapy Among Graduate Students: Cross-sectional Study (Preprint)
Authors: Blair Samari A , Brockmann Andrea N , Arroyo Kelsey M , Carpenter Chelsea A , Ross Kathryn M
Published: July 2022

BACKGROUND

Research has suggested that there is a mental health crisis occurring among graduate students in the United States. Moreover, many students go without effective treatment owing to the limited availability of mental and behavioral health resources on college campuses. Text-based therapy may represent a viable method for increasing access to mental health support for graduate students, but little is known regarding its acceptability in this population.

OBJECTIVE

The purpose of this study was to assess how graduate students perceive text-based therapy and their likelihood of seeking out this form of therapy.

METHODS

In total, 265 graduate students completed a cross-sectional web-based survey that included multiple-choice and open-ended questions assessing their perceptions of text-based therapy and the likelihood of seeking out this form of therapy. Chi-square tests, ANOVAs, and nonparametric Wilcoxon signed-rank tests were used to examine differences in multiple-choice questions. The constant comparative method was used for qualitative analyses of the open-ended question responses.

RESULTS

Participants (n=265) were predominately non-Hispanic White (166/265, 62.6%) and female (167/265, 63%) with a mean age of 28.3 (SD 5.1) years. Over half of the participants (139/265, 52.5%) were not aware that text-based therapy existed; however, 65.3% (173/265) reported that they would consider using text-based services, if available. In comparison to face-to-face therapy, participants reported being less likely to seek out text-based therapy and perceived it as less effective (P<.001). Qualitative results indicated that participants were concerned about the ability to effectively communicate and build rapport through text-based therapy and thought that this modality may be more effective for some mental and behavioral health concerns than others. Moreover, participants noted that text-based therapy would be best implemented as a way to supplement, rather than replace, face-to-face services.

CONCLUSIONS

Altogether, the results of this study suggest that text-based therapy holds the potential to increase access to and use of mental and behavioral health services; however, graduate students remain concerned about its effectiveness and the optimal methods of implementation. Future research should investigate how therapeutic processes (eg, effective communication and rapport-building) can be facilitated in digital environments and how text-based therapy could be best implemented to supplement and extend, rather than replace, face-to-face services.
Shortening the Time Interval for Soft Tissue Sarcoma Patient Referral to Expert Centers: Application of mHealth for Rare Tumors (Preprint)
Authors: Nannini Simon , Penel Nicolas , Bompas Emmanuelle , Willaume Thibault , Kurtz Jean-Emmanuel , Gantzer Justine
Published: July 2022

BACKGROUND

According to guidelines, all sarcoma patients must be managed from initial diagnosis at expert sarcoma centers. However, in everyday practice, the time interval to an expert center visit can be long, which delays presentation to an expert multidisciplinary tumor board (MTB) and increases the risk of inappropriate management, negatively affecting local tumor control and prognosis. The advent of mobile health (mHealth) offers an easy way to facilitate communication and cooperation between general health care providers (e.g., general practitioners and radiologists) and sarcomas experts. We developed a mobile application (Sar’Connect) based on the algorithm designed by radiologists from French Sarcoma Group. Through a small number of easy-to-answer questions, Sar’Connect provides personalized advice for management of patients and contact information on the closest expert center.

OBJECTIVE

This retrospective study is the first to assess this mobile application’s benefits in reducing the time interval for patient referral to an expert center according to the initial clinical characteristics of the soft tissue tumor.

METHODS

We extracted tumor mass data for 78 patients discussed by MTBs of three centers of French Sarcoma Group. We applied the Sar’Connect algorithm to these data and estimated the time interval to expert center referral; then, we compared this estimated time interval with the observed time interval.

RESULTS

We found that the use of Sar’Connect shortened the time interval to a referral center by approximately 7.5 months. Moreover, for half of patients with a malignant soft tissue tumor, Sar’Connect avoided inappropriate management outside of the reference center. We did not identify a significant determinant for shortening the time interval for referral.

CONCLUSIONS

Overall, promoting the use of a simple mobile application is an innovative and straightforward means to accelerating both the referral and management of soft tissue sarcoma patients in expert centers.
Occurrence and type of complications associated with mandibular bilateral removable partial denture: Prospective cohort data
Authors: Tôrres Ana Clara Soares Paiva , Pereira Ana Larisse Carneiro , Dias Kássia de Carvalho , Cardoso Rachel Gomes , Calderon Patrícia dos Santos , Carreiro Adriana da Fonte Porto
Published: July 2022

Purpose. The aim of this study was to assess the occurrence and type of complications with mandibular Kennedy Class I removable partial denture (RPD) over time. Materials and Methods. A total of 65 patients wearing mandibular free-end RPD and maxillary complete denture (CD) treated at the Department of Dentistry of Federal University of Rio Grande do Norte (UFRN) were evaluated. The tests were conducted after 2, 6 and 12 months. Annual follow-up was also accomplished after the 12-month evaluation. Complications or failures were recorded in a specific clinical report over 39 months. The failures were classified as: ulceration after 2 months of denture insertion, loss of retention, fracture or caries in rest seat, fracture or displacement of artificial teeth, fracture of a major connector, fracture of a clasp, fracture of the rest, relining and fracture of the denture. Results. Low complication rate was reported and most of the cases occurred after 2 years of denture insertion. Loss of retention was the most common complication (31.57%). Fracture of the metallic framework components was not a frequent occurrence and only one patient reported a fracture of a major connector (5.3%). Conclusion. The treatment with mandibular free-end RPD showed low failure rates after 39 months of periodical follow-up.
The Challenges of Marketing Organic Products: leafy vegetables in the Municipal Organic Market in Petrolina-PE
Authors: Lopes Veronica Maria Neto , Ferreira Liliane Caraciolo , Ferreira Caliane Borges
Published: July 2022

The offer of organic vegetables, such as leafy vegetables, is increasingly frequent in small community fairs, such as the one that takes place at the Municipal Organic Market in Petrolina-PE. Considering that the research points to losses in the process that involves the post-harvest and commercialization of in natura products, but need to be more frequent in interior cities, the present study aimed to verify the existence of losses in the commercialization of coriander (Coriandrum sativum), chives (Allium schoenoprasum), lettuce (Lactuca sativa) and kale (Brassica oleracea) among four producers that sell in the market. The methodology used was a field study with site visits during the fairs from 02/27/2022 to 03/27/2022 and conducting an interview with the producers. Although the results have pointed to low levels of losses in the sale of leafy vegetables in the market, they have elucidated some determining factors of the same, which need to be corrected to improve the activity in the place. It is noteworthy that the low quantity of losses identified during the study may be correlated with the cooperation present in the group, the friendly relationship between the group and the customers, the small number of products offered, or the fact that they are organic being well evaluated by consumers.
Residential Graywater Treatment Through Phytoremediation
Authors: Barbosa Fábio José de Matos , Freitas Helder Ribeiro , Vieira Denes Dantas , Amorim Míriam Cleide Cavalcante de , Sousa Jose Getúlio Gomes
Published: July 2022

In a globalized world with information on environmental issues, it is observed an increasing number of researches focusing on issues related to soil and water pollution. In this context, the reuse of domestic waters (gray waters) for reuse in agriculture with ecological technology, appears as one of the alternatives to equate water demand and supply, especially in the caatinga biome of the semiarid northeast, characterized by low rainfall. Several techniques are being studied and phytoremediation among the other techniques has had a differentiated attention due to its efficiency and low cost. This study is based on the literature review of several works developed in Brazil and in the world, all related exclusively to the theme. This Review was developed through the analysis of the available material on the in the international databases SCIELO, Science Direct, Springer Journal, Embase and PubMed, as well as dissertations and theses that were developed in the area of the use of phytoremediation for effluent treatment.
The Consequences of Unfreedom: Learning from Story Amidst a Global Climate Crisis
Authors: Robinson Meghan
Published: July 2022

As the world navigates the impending consequences of climate change, Canada remains one of the few countries to reject the right to a healthy environment for its citizens within the Canadian Constitution. Although Canada purports itself to be a free and democratic society, many argue that their freedoms are continually neglected by laws that continue to disregard the environment and, therefore, their right to a healthy existence. This article is an investigation into a particular word that is woven throughout Canada’s Constitution: “freedom.” It is an investigation into the conflicting understandings of the word and how these contrasting meanings have impacted Canada’s Constitution and its relationship to land. This article analyzes the history of freedom as seen through a liberal belief system and contrasts this understanding with Indigenous concepts of freedom, as told through Haisla and Nuu-chah-nulth stories. These narratives explore how the differing concepts of freedom have affected relationships with the land and the laws that govern the land. Finally, the discussion of these themes draws upon the possibility of using story within Canada’s laws to change the Constitution’s current relationship with the land in order to mitigate the potential effects of climate change. I argue that the liberal, colonialist world view is ever present in our current legal system and is in fact facilitated through the word “freedom.” Until we begin to re-story our Constitution through a diversity of understandings and world views, Canada will continue to ignore the looming ramifications of climate change.
The Quantum Approximate Optimization Algorithm and the Sherrington-Kirkpatrick Model at Infinite Size
Authors: Farhi Edward , Goldstone Jeffrey , Gutmann Sam , Zhou Leo
Published: July 2022

The Quantum Approximate Optimization Algorithm (QAOA) is a general-purpose algorithm for combinatorial optimization problems whose performance can only improve with the number of layers p. While QAOA holds promise as an algorithm that can be run on near-term quantum computers, its computational power has not been fully explored. In this work, we study the QAOA applied to the Sherrington-Kirkpatrick (SK) model, which can be understood as energy minimization of n spins with all-to-all random signed couplings. There is a recent classical algorithm by Montanari that, assuming a widely believed conjecture, can efficiently find an approximate solution for a typical instance of the SK model to within (1−ϵ) times the ground state energy. We hope to match its performance with the QAOA.Our main result is a novel technique that allows us to evaluate the typical-instance energy of the QAOA applied to the SK model. We produce a formula for the expected value of the energy, as a function of the 2p QAOA parameters, in the infinite size limit that can be evaluated on a computer with O(16p) complexity. We evaluate the formula up to p=12, and find that the QAOA at p=11 outperforms the standard semidefinite programming algorithm. Moreover, we show concentration: With probability tending to one as n→∞, measurements of the QAOA will produce strings whose energies concentrate at our calculated value. As an algorithm running on a quantum computer, there is no need to search for optimal parameters on an instance-by-instance basis since we can determine them in advance. What we have here is a new framework for analyzing the QAOA, and our techniques can be of broad interest for evaluating its performance on more general problems where classical algorithms may fail.
PENGEMBANGAN BAHAN AJAR BAHASA DAN SASTRA INDONESIA DENGAN MENGGUNAKAN PENDEKATAN TEMATIS PADA SISWA KELAS XI SMA NEGERI 1 TAPAKTUAN
Authors: Radhitullah Radhitullah
Published: July 2022

Education at SMA Negeri 1 Tapaktuan is still faced with 4 obstacles in improving the quality of education, namely: (1) limited number of teachers and TU; (2) the uneven distribution of teachers; (3) lack of teacher professionalism; and (4) various facilities for teaching and learning activities that do not meet the standards, in particular the lack of procurement of Indonesian language textbooks that are relevant to the needs of students, schools, and regions in accordance with the demands of K-13. This research was conducted with the objectives of: (1) formulating the need for teaching materials according to teachers and students; (2) developing prototypes into Indonesian language and literature teaching materials with a thematic approach in high school; (3) knowing the effectiveness of the developed teaching materials; and (4) determine the feasibility of teaching materials for Indonesian language and literature with a thematic approach in high school. The research and development (R&D) method is used in this research to produce teaching materials. The results obtained:  1)  the  need  for  teaching  materials  according  to  teachers  and  students, paying attention to: (a) the language context for various language purposes, (b) keeping up with the times, (c) according to K13 by raising themes around students, (d) relevance between teacher and student teaching materials; (f) assignments/practices can activate students, (g) the material attracts students' interest, is clear, and easy to understand, and (h) is relatively ready to use in minimal school facilities; 2) developing prototypes into Indonesian language and literature teaching materials with a thematic approach in high school is done by: (a) compiling syllabus, lesson plans, teacher teaching materials and student teaching materials, (b) authentic  materials  and  assignments/exercises  developed  thematically  and situational and develop intellectual and affective insight, and (c) the assessment process is carried out by classroom assessment; 3) the results of the effectiveness test with  a  non-independent  t-test  showed  that  the thematic  teaching  materials  were effective; and 4) the results of the feasibility of developing Indonesian language and literature teaching materials with a thematic approach are stated to be good with components of content/material feasibility assessment 77.92%, linguistics 73.40%, material presentation 77.92%, and graphics 70.
PERSEPSI MAHASISWA PGMI UIN AR-RANIRY TERHADAP SISTEM PEMBELAJARAN ONLINE PADA MASA AWAL PANDEMI COVID-19
Authors: ‘Ulya Khairatul , Oviana Wati , Jannah Misbahul
Published: July 2022

Online study had been conducted in Islamic Elementary School Teacher Study Program (PGMI) at UIN Ar-Raniry far before the pandemic happened, the difference was the studying process was not entirely conducted online at that time. Therefore, this study aims to know the Islamic Elementary School Teacher Study Program (PGMI) student’s perception toward the online study system during Covid-19, the problem faced while the study process and the solution used to anticipate the obstacle during online study. This research used a qualitative descriptive method with a total 40 samples from purposive sampling technique. The data collection was conducted by questionnaire via google form and interviewed 15 participants to collect the detailed information. The result shows there are various perceptions from the participants toward online study and some arguments with a highest percentage, 100% students said that the internet connection was the common problem while 90% of students have difficulties in understanding online material. Those are the problems faced by PGMI students during the online study process. Besides, the students are still able to find a place with a better internet connection and learn independently. In conclusion, the online study process held during Covid-19 pandemic was not effective based on the student’s perception.
IMPLEMENTASI METODE KITABAH DAN METODE WAHDAH DALAM PEMBELAJARAN TAHFIDZ SISWA SEKOLAH DASAR
Authors: Nurfitriani Rahmah , Hidayat Muhammad Almi , Musradinur Musradinur
Published: July 2022

SD Plus Jabal Rahmah Mulia is one of elementary schools that prioritizes tahfidz learning by target of memorizing five juz for each graduate. Teaching memorization of Quran is not an easy, so the tahfidz teacher must use the right method. The method applied by one of the first grade tahfidz teachers at SD Plus Jabal Rahmah Mulia is Kitabah method and  Wahdah method. This study seeks to explore the steps for applying the Kitabah method and Wahdah method as well as examining factors that influence the success of students in achieving memorization target. This study uses a qualitative method with data collection techniques of observation, interviews and documentation. Data analysis technique is through the stages of data reduction, data presentation and conclusions. Results showed that the steps of memorizing the Quran with Kitabah method and Wahdah method were 1) Students wrote the memorized verse, 2) Teacher tahfidz read the first verse with the rhythm of Imam Thoha Al Junayd, repeated ten times and followed by the students, 3) After all the students memorized correctly, followed by the next verse ten times, 4) Combining the first verse and the follow-up verse five times, 5) Teacher and students repeat the entire verse ten times. The determinants of student success in memorizing are health, psychological, intelligence and motivation factors.
PENGARUH MEDIA PLOTAGON TERHADAP HASIL BELAJAR SISWA KELAS V PADA MATA PELAJARAN IPA MATERI KALOR DI SDN CIBUNTU 01
Authors: Nurhaura Syafira Eka , Zulfadewina Zulfadewina
Published: July 2022

The development of education in Indonesia is undergoing rapid changes, therefore we as Indonesian citizens must prepare ourselves so as not to be out of date. In the teaching and learning process sometimes there are students who feel bored and bored when the lesson takes place so that they have difficulty in understanding the material presented by the teacher and cause low student learning outcomes. This study aims to determine whether or not plotagon media has an effect on the learning outcomes of fifth graders at SDN Cibuntu 01. The sample in this study was class V at SDN Cibuntu 01 which consisted of 2 groups of data, namely the experimental class of 27 students and the control class of 25 students. The instrument in this study used a learning outcomes test sheet in the form of multiple choice. The experimental design used in this study was the Posttest-Only Control Design method. Data analysis used independent sample t-test. It is obtained that the value of sig. 0.000 < 0.05 of Sig.(2-tailed). So it can be concluded that plotagon media can affect the value of student learning outcomes at SDN Cibuntu 01.
Girays’ Steppe Diplomacy. The Message of Khan Janibek Giray of 1633
Authors:   Institute of Russian History of the Russian Academy of Sciences, Akhmadullin Salavat Z. , Trepavlov Vadim V. ,   Institute of Russian History of the Russian Academy of Sciences
Published: July 2022

A letter from the Сrimean Khan Janibek Giray to the Nogay Horde of 1633, preserved in the Stock 123 “Russia’s Relations with the Nogay Tatars” of the Russian State Archive of Ancient Acts, is published here. At that time, the Nogay Horde was in a state of complete decline and decay. Intestine strife of Nogay nobles, destructive strikes against the Kalmyks, who occupied the former Nogai pastures over the Volga river, oppression by Russian Astrakhan local governors led to the fact that the Nogays used to move to neighboring countries – in an intention to find peace and protection there. One of desirable and traditional areas of migration were the North Black Sea steppes, which were under the authority of the Girays. The Khan’s message was addressed to the mirzas and ignorant leaders of the nomadic communities, but not to the nominal ruler of the Horde biy Kanay, because in the 1630s he completely lost his remaining authority. One of the reasons of the Khan’s appeal was the search of new human resources (albeit in the form of relatively poor, but numerous steppe people) to strengthen his power in the state, thoroughly weakened by long internecine turmoil – the feud between the aristocratic clans of Shirins and Mansurs. In addition, extension horsemen were needed for raids on the Russian borders, which became more frequent at a time when the forces of the Moscow state were diverted to the Smolensk war. In the address to Nogays the Khan does not designate specific conditions of their stay in his subjection, he only names the area of the Dnieper, through which migrants from the East would roam. Janibek Giray placed the main emphasis on co-belief and called for Islamic solidarity. Loyal to the Russian authorities, mirzas delivered the Crimean letter to Astrakhan, from where the governors sent it to Moscow. The archive keeps the original letter and its Russian translation, made by the Foreign affairs’ office (Posol’sky prikaz). This publication introduces the facsimile of the document and its translations (of the 17th century and modern).
Alan Fisher. The Crimean Tatars
Authors:   Marjani Institute of History of the Tatarstan Academy of Sciences, Seyitkhalilova Leylya S. , Alieva Arzy Yu. ,   Marjani Institute of History of the Tatarstan Academy of Sciences
Published: July 2022

The given article is a translation from English of the well- known scholar, historian Alan Fisher`s work The Crimean Tatars. He was a professor of State University in Michigan, the USA. He had life -long interest to the history of Ottoman Empire and Turkic peoples. His work The Crimean Tatars was published in 1978 in the USA. The work consists of several chapters:1. The Origins of the Crimean Tatar Khanate. 2. Ottoman Hegemony in the Crimea. 3. The Political system of the Crimean Khanate. 4. Economic and Cultural Life in the khanate. 5. The Crimean Role in Eastern European Politics. The first chapter of the work gives a detailed study of the Origins of the Crimean Tatar Khanate, relations with the neighboring countries: Ottoman Empire, Moscovy, Poland and so on. The author represents an in- depth analyses of each ruling khan, his contribution into coming into being of the Khanate: Sahib Giray, Devlet Giray, Gazi Giray, Selim Giray I In the first chapter the author also offers detailed information about political and economic life of the Khanate.