bluuebunny/crossref_metadata_2025 huggingface dataset:
High-performance silicon TE-pass polarizer assisted by anisotropic metamaterials
Authors: Lin Zongxing , Li Xiao , He Sailing
Published: June 2022

The polarizer is a key component for integrated photonics to deal with the strong waveguide birefringence, especially for silicon photonics. A high-performance silicon TE-pass polarizer covering all optical communication bands with low insertion loss (IL) and high polarization extinction ratio (PER) is proposed here. This polarizer is based on anisotropic subwavelength grating (SWG) metamaterials, which maintain the fundamental TE mode as a guided mode but make the fundamental TM mode leaky. Furthermore, based on this working mechanism, the proposed polarizer can work well for any upper cladding material, including air and silicon dioxide (SiO2). The numerical results show that our proposed TE-pass polarizer has a remarkable performance with IL < 0.34 dB over 420 nm (PER > 23.5 dB) or 380 nm (PER > 30 dB) for the air cladding, and IL < 0.3 dB over 420 nm (PER > 25 dB) or 320 nm (PER > 30 dB) for the SiO2 cladding. The fabricated polarizer shows IL < 0.8 dB and PER > 23 dB for the bandwidths of 1.26-1.36 µm and 1.52-1.58 µm (other bandwidths were not measured due to the limited instrument in our research center, but it still covers the most important O-band and C-band).
Highly efficient diode-pumped alkali-vapor amplification with near-extreme-limit gain
Authors: Kim Heewoo , Jeong Yujae , Hwang Kyeongjun , Yeom Dong-Il , Moon Han Seb
Published: June 2022

We report high-efficiency optical amplification with near-extreme-limit gain from a diode-pumped Cs vapor cell. We used wavelength-division multiplexing to couple 852 nm pump and 895 nm seed lasers to achieve nearly overlapping spatial modes in the Cs vapor cell. We investigated the amplification factor as a function of the focal length of the lens focusing on the combined pump and seed signals and determined the optimal focal length under our experimental conditions. The small-signal amplification factor from the Cs vapor cell reached >30 dB at 240 mW pump power, and the optimal optical amplification factor per pump power was 4171/W.
Computational see-through screen camera based on a holographic waveguide device
Authors: Chen Xiao , Tagami Noriyuki , Konno Hiroki , Nakamura Tomoya , Takeyama Saori , Pan Xiuxi , Yamaguchi Masahiro
Published: June 2022

This study proposes a novel computational imaging system that integrates a see-through screen (STS) with volume holographic optical elements (vHOEs) and a digital camera unit. Because of the unique features of the vHOE, the STS can function as a holographic waveguide device (HWD) and enable the camera to capture the frontal image when the user gazes at the screen. This system not only provides an innovative solution to a high-quality video communication system by realizing eye-contact but also contributes to other visual applications due to its refined structure. However, there is a dilemma in the proposed imaging system: for a wider field of view, a larger vHOE is necessary. If the size of the vHOE is larger, the light rays from the same object point are diffracted at different Bragg conditions and reflect a different number of times, which causes blurring of the captured image. The system imaging process is analyzed by ray tracing, and a digital image reconstruction method was employed to obtain a clear picture in this study. Optical experiments confirmed the effectiveness of the proposed HWD-STS camera.
Multimode interferometric sensor based on the no-core tellurite optical fiber for cryogenic temperature detection
Authors: Liu Wei , Song Dianchang , Yin Zhiyuan , Zhang Fan , Li Bin , Zhang Xuenan , Wang Fang , Suzuki Takenobu , Ohishi Yasutake , Cheng Tonglei
Published: June 2022

In this paper, a no-core tellurite optical fiber (NCTOF)-based sensor was proposed for cryogenic temperature detection in refrigeration process. The ultraviolet adhesive (UVA) dual-curing method was operated to stablish a sandwich-like composite structure, in which a section of NCTOF was compactly sandwiched between two segments of silica fiber to form multimode interference. The temperature sensing characteristics in cryogenic range were experimentally investigated by monitoring the transmission spectral movement, where a high sensitivity of 105.6 pm/°C was achieved in the range of −20-0 °C and 51.6 pm/°C in the range of −20-25 °C. The excellent performance was consistent with the simulation analysis. The maximum repeatability standard deviation and stability wavelength error of the sensor are 0.9799 pm/°C and 0.1676 nm, respectively. To the best of our knowledge, this is the first report on using tellurite optical fibers for cryogenic temperature detection, and the UVA dual-curing method provides a reliable solution for the integration and practical application of tellurite optical fiber. The proposed sensor is simple in structure, easy in fabrication, low in cost and excellent in performance. It can be expected to be used in food refrigeration, air-conditioning engineering, medical and health, industrial production, etc.
Designing thermal radiation metamaterials via a hybrid adversarial autoencoder and Bayesian optimization
Authors: Zhu Dezhao , Guo Jiang , Yu Gang , Zhao C. Y. , Wang Hong , Ju Shenghong
Published: June 2022

Designing thermal radiation metamaterials is challenging especially for problems with high degrees of freedom and complex objectives. In this Letter, we develop a hybrid materials informatics approach which combines the adversarial autoencoder and Bayesian optimization to design narrowband thermal emitters at different target wavelengths. With only several hundreds of training data sets, new structures with optimal properties can be quickly determined in a compressed two-dimensional latent space. This enables the optimal design by calculating far less than 0.001% of the total candidate structures, which greatly decreases the design period and cost. The proposed design framework can be easily extended to other thermal radiation metamaterials design with higher dimensional features.
Single-wavelength transmission at 1.1-Tbit/s net data rate over a multi-modal free-space optical link using commercial devices
Authors: Hu Zhouyi , Li Yiming , Benton David M. , Ali Abdallah A. I. , Patel Mohammed , Ellis Andrew D.
Published: June 2022

We employ commercial mode-selective photonic lanterns to implement mode multiplexing and demultiplexing for high-capacity free-space optical communications. Moreover, we design a time-division-multiplexed frame structure to efficiently emulate multiple independent transmitters with channelized precoding using only one transmitter. To maximize the throughput of the system, we optimize the modes selected for carrying data, and apply adaptive loading to different channels. By leveraging mode- and polarization-division multiplexing, the free-space optical data link comprising multiple independent channels provides an aggregate net data rate of 1.1 Tbit/s and net spectral efficiency of 28.35 bit/s/Hz. Different from many previous demonstrations based on delayed or partially delayed copies of identical data streams, to the best of our knowledge, ours is a record-high net data rate and net spectral efficiency achieved by a single-wavelength mode-division multiplexed free-space optical communication system with fully independent channels. Moreover, all key devices used in this work, including optical transponder, multiplexer, and demultiplexer are commercially available.
Glass, optics and IYOG: opinion
Authors: Parker John M. , Durán Alicia
Published: June 2022

How glass objects have evolved from simple artefacts valued for their appearance to sophisticated devices that have transformed our lives through their ability to manipulate light.
The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution
Authors: Böndel Katharina B. , Samuels Toby , Craig Rory J. , Ness Rob W. , Colegrave Nick , Keightley Peter D.
Published: June 2022

The distribution of fitness effects (DFE) for new mutations is fundamental for many aspects of population and quantitative genetics. In this study, we have inferred the DFE in the single-celled algaChlamydomonas reinhardtiiby estimating changes in the frequencies of 254 spontaneous mutations under experimental evolution and equating the frequency changes of linked mutations with their selection coefficients. We generated seven populations of recombinant haplotypes by crossing seven independently derived mutation accumulation lines carrying an average of 36 mutations in the haploid state to a mutation-free strain of the same genotype. We then allowed the populations to evolve under natural selection in the laboratory by serial transfer in liquid culture. We observed substantial and repeatable changes in the frequencies of many groups of linked mutations, and, surprisingly, as many mutations were observed to increase as decrease in frequency. Mutation frequencies were highly repeatable among replicates, suggesting that selection was the cause of the observed allele frequency changes. We developed a Bayesian Monte Carlo Markov Chain method to infer the DFE. This computes the likelihood of the observed distribution of changes of frequency, and obtains the posterior distribution of the selective effects of individual mutations, while assuming a two-sided gamma distribution of effects. We infer that the DFE is a highly leptokurtic distribution, and that approximately equal proportions of mutations have positive and negative effects on fitness. This result is consistent with what we have observed in previous work on a differentC.reinhardtiistrain, and suggests that a high fraction of new spontaneously arisen mutations are advantageous in a simple laboratory environment.
Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells
Authors: Barnada Samantha M. , Isopi Andrew , Tejada-Martinez Daniela , Goubert Clément , Patoori Sruti , Pagliaroli Luca , Tracewell Mason , Trizzino Marco
Published: June 2022

Domestication of transposable elements (TEs) into functional cis-regulatory elements is a widespread phenomenon. However, the mechanisms behind why some TEs are co-opted as functional enhancers while others are not are underappreciated. SINE-VNTR-Alus (SVAs) are the youngest group of transposons in the human genome, where ~3,700 copies are annotated, nearly half of which are human-specific. Many studies indicate that SVAs are among the most frequently co-opted TEs in human gene regulation, but the mechanisms underlying such processes have not yet been thoroughly investigated. Here, we leveraged CRISPR-interference (CRISPRi), computational and functional genomics to elucidate the genomic features that underlie SVA domestication into human stem-cell gene regulation. We found that ~750 SVAs are co-opted as functional cis-regulatory elements in human induced pluripotent stem cells. These SVAs are significantly closer to genes and harbor more transcription factor binding sites than non-co-opted SVAs. We show that a long DNA motif composed of flanking YY1/2 and OCT4 binding sites is enriched in the co-opted SVAs and that these two transcription factors bind consecutively on the TE sequence. We used CRISPRi to epigenetically repress active SVAs in stem cell-like NCCIT cells. Epigenetic perturbation of active SVAs strongly attenuated YY1/OCT4 binding and influenced neighboring gene expression. Ultimately, SVA repression resulted in ~3,000 differentially expressed genes, 131 of which were the nearest gene to an annotated SVA. In summary, we demonstrated that SVAs modulate human gene expression, and uncovered that location and sequence composition contribute to SVA domestication into gene regulatory networks.
Enhancing the knowledge of parents on child health using eLearning in a government school in the semi-rural community of Karachi, Pakistan
Authors: Gulzar Saleema , Saeed Sana , Taufiq Kirmani Salimah , Karmaliani Rozina
Published: June 2022

Education is one of the vital social determinants of health. Health and education share a symbiotic relationship for all cadre including children and adolescents to ensure that they are well equipped to combat the health risk in the environment. The current literature globally found some initiatives to create health awareness among school children. However, there is a dearth of studies available addressing parental health awareness through school platforms. Therefore, the current study aims to fill this gap, and the Aga Khan University School of Nursing and Midwifery initiated the School Health Program (SHP) in one of the remote communities in Sindh, Pakistan. The overall goal of the study was to improve children’s health by enhancing the health awareness of the parents through school platforms utilizing online modalities. Another objective of this study was to identify the effect of using eLearning on parental knowledge and perceptions. The study utilized a sequential explanatory mixed-method design. Twelve health awareness sessions relevant to children’s health using eLearning were conducted over one year. Parents’ knowledge was assessed through a pre-posttest, which was administered after each teaching session. Subsequently, focused group discussions were carried out with parents, community leaders, and schoolteachers to gain insights regarding the effectiveness of the health education program. The pre-and post-test results showed again in knowledge in nine out of twelve sessions. The findings from qualitative content analysis yielded three key themes: Perceived usefulness of eLearning, Barriers affecting usability, and Way forward for eLearning through school platforms. The study showed parental satisfaction with the online health education awareness program. They exhibited enthusiasm and desire for further similar sessions in the future. The results demonstrated an enhancement in parental awareness about common health conditions among school children. This study may be replicated on a larger scale in the schools of Pakistan.
Assessment of neonatal thermal cares: Practices and beliefs among rural women in West Guji Zone, South Ethiopia: A cross-sectional study
Authors: Wako Wako Golicha , Beyene Belda Negesa , Wayessa Zelalem Jabessa , Fikrie Aneteneh , Amaje Elias
Published: June 2022

A newborn has a limited capacity to maintain temperature when exposed to cold environment. Neonatal hypothermia, a common neonatal problem, carries high case fatality rate particularly if concurrently occurs with other neonatal problems. This study assessed neonatal thermal care practices and beliefs among rural women in west Guji Zone, south Ethiopia. A community based cross sectional quantitative study combined with qualitative study was undertaken in rural areas of west Guji Zone, Ethiopia. Randomly selected 388 rural mothers of infants less than 6 months old were participated in the quantitative study. Three focus group discussions were conducted among mothers of infants less than 6 months old. Quantitative data were collected by using structured and pretested Afaan Oromo version questionnaire adapted from relevant literatures. Qualitative data were collected by focus group discussion guide. The quantitative data were cleaned, coded and analyzed by SPSS version 20. Qualitative data were transcribed, translated, coded, and analyzed by thematic analysis approach. In general rural women believe that thermal protection of newborn is important. The findings show that approximately 75% and 85% of newborns were dried and wrapped respectively after delivery. However drying and wrapping of newborn are usually done after the first newborn’s bath. Just over 84% of newborns were bathed within the first 6 hours of delivery and majority of them were bathed with warm water. About 69.1% and 57.7% of women put head cover to their newborns immediately after birth, and initiated breast feeding within one hour of delivery respectively. Skin to skin care of newborn is non-existent in the study area and perceived as an odd, frightening and potentially dangerous practice. Studied women practice some of the recommended neonatal thermal cares and believe in their importance in keeping newborn warm. However, practice and beliefs about delayed first bath is against standard recommendation, whereas skin to skin care is non-existent and perceived as an odd practice. Interventions to familiarize skin to skin care and reduce misconceptions surrounding it should be introduced into the study area to improve thermal cares of high risk newborns.
Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil
Authors: Falcão Eduardo Mastrangelo , de Macedo Priscila Marques , Freitas Dayvison Francis Saraiva , Freitas Andréa d’Avila , Grinsztejn Beatriz , Veloso Valdiléa Gonçalves , Almeida-Paes Rodrigo , do Valle Antonio Carlos Francesconi
Published: June 2022

Paracoccidioidomycosis (PCM) is one of the main endemic systemic mycoses in Latin America, usually occurring in rural areas. When PCM occurs simultaneously with underlying immunosuppressive conditions, it can present as an opportunistic disease. Between 2000 and 2017, literature reported around 200 PCM cases in people living with HIV/AIDS (PLWHA). To address research gaps on this co-infection and to study its possible temporal changes in the last decade, we performed an active co-infection case search on the HIV/AIDS and PCM cohorts from a Brazilian reference center database from 1989 to 2019. We found 20 PLWHA among 684 PCM patients (2.92%), predominantly male (70.0%) and urban workers (80.0%). The median age of patients was higher in the 2010–2019 decade (p = 0.006). The occurrence of PCM in PLWHA was lower when compared with other fungal diseases. Although 50.0% of the patients had already been diagnosed with HIV infection and presented CD4+ T cell counts greater than 200/mm3 at the time of PCM diagnosis, the suspicion of immunosuppression in the context of atypical and more severe clinical forms of PCM revealed the diagnosis of HIV infection in 35.0% of the patients. Two (10.0%) patients had an evolution compatible with immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy (ART).We highlight the importance of considering a PCM diagnosis in PLWHA to prevent a late-onset treatment and progression to severe manifestations and unfavorable outcomes. In addition, HIV investigation is recommended in PCM patients, especially those with atypical and more severe clinical presentations.
Data integration of National Dose Registry and survey data using multivariate imputation by chained equations
Authors: Kim Ryu Kyung , Kim Young Min , Lee Won Jin , Im Jongho , Lee Juhee , Bang Ye Jin , Cha Eun Shil
Published: June 2022

Introduction

Data integration is the process of merging information from multiple datasets generated from different sources, which can obtain more information in comparison to to one data source. All diagnostic medical radiation workers were enrolled in National Dose Registry (NDR) from 1996 to 2011, linked with mortality and cancer registry data. (https://kdca.go.kr/) Survey was conducted during 2012-2013 using self-reported questionnaire on occupational radiation practices among diagnostic medical radiation workers.

Methods

Data integration of NDR and Survey was performed using the multivariate imputation by chained equations (MICE) algorithm.

Results

The results were compared by sex and type of job because characteristics of target variables for imputation depend on these variables. There was a difference between the observed and pooled mean for the frequency of interventional therapy for nurses due to different type of medical facility distribution between observed and completed data. Concerning the marital status of males and females, and status of pregnancy for females, there was a difference between observed and pooled mean because the distribution of the year of birth was different between the observed and completed data. For lifetime status of smoking, the percentage of smoking experience was higher in the completed data than in the observed data, which could be due to reasons, such as underreporting among females and the distribution difference in the frequency of drinking between the observed and completed data for males.

Conclusion

Data integration can allow us to obtain survey information of NDR units without additional surveys, saving us time and costs for the survey.
Efficacy and safety of a food supplement with standardized menthol, limonene, and gingerol content in patients with irritable bowel syndrome: A double-blind, randomized, placebo-controlled trial
Authors: Ivashkin Vladimir T. , Kudryavtseva Anna V. , Krasnov George S. , Poluektov Yuri M. , Morozova Margarita A. , Shifrin Oleg S. , Beniashvili Allan G. , Mamieva Zarina A. , Kovaleva Alexandra L. , Ulyanin Anatoly I. , Trush Elizaveta A. , Erlykin Alexander G. , Poluektova Elena A.
Published: June 2022

Background

Irritable bowel syndrome (IBS) affects 9,2% of the global population and places a considerable burden on healthcare systems. Most medications for treating IBS, including spasmolytics, laxatives, and antidiarrheals, have low efficacy. Effective and safe therapeutic treatments have yet to be developed for IBS.

Purpose

This study assessed the efficacy and safety of a food supplement containing standardized menthol, limonene, and gingerol in human participants with IBS or IBS/functional dyspepsia (FD).

Design

A double-blind, randomized, placebo-controlled trial.

Methods

We randomly assigned 56 patients with IBS or IBS/FD to an intervention group (Group 1) or control group (Group 2) that were given supplement or placebo, respectively, in addition to the standard treatment regimen for 30 d. Three outpatient visits were conducted during the study. Symptom severity was measured at each visit using a 7×7 questionnaire. Qualitative and quantitative composition of the intestinal microbiota were assessed at visits 1 and 3 based on 16S rRNA gene sequencing.

Results

At visit 1 (before treatment), the median total 7×7 questionnaire score was in the moderately ill range for both groups, with no difference between the groups (p= 0.1). At visit 2, the total 7×7 score decreased to mildly ill, with no difference between the groups (p= 0.4). At visit 3, the total score for group 1 indicated borderline illness and for group 2 remained indicated mild illness (p= 0.009). Even though we observed some variations in gut microbiota between the groups, we did not find any statistically significant changes.

Conclusion

The food supplement with standardized menthol, limonene, and gingerol content increased the efficacy of standard therapy in IBS and FD patients. The use of the supplement did not cause any obvious side effects.

Registration

ClinicalTrials.gov Identifier:NCT04484467
Were there royal herds? Understanding herd management and mobility using isotopic characterizations of cattle tooth enamel from Early Dynastic Ur
Authors: Greenfield Tina L. , McMahon Augusta M. , O’Connell Tamsin C. , Reade Hazel , Holmden Chris , Fletcher Alexandra C. , Zettler Richard L. , Petrie Cameron A.
Published: June 2022

During the third millennium BC, Mesopotamia (the land between the Tigris and Euphrates Rivers, in modern Iraq-Syria), was dominated by the world’s earliest cities and states, which were ruled by powerful elites. Ur, in present-day southern Iraq, was one of the largest and most important of these cities, and irrigation-based agriculture and large herds of domesticated animals were the twin mainstays of the economy and diet. Texts suggest that the societies of the Mesopotamian city-states were extremely hierarchical and underpinned by institutionalised and heavily-managed farming systems. Prevailing narratives suggest that the animal management strategies within these farming systems in the third millennium BC were homogenous. There have been few systematic science-based studies of human and animal diets, mobility, or other forms of human-animal interaction in Mesopotamia, but such approaches can inform understanding of past economies, including animal management, social hierarchies, diet and migration. Oxygen, carbon and strontium isotopic analysis of animal tooth enamel from both royal and private/non-royal burial contexts at Early Dynastic Ur (2900–2350 BC) indicate that a variety of herd management strategies and habitats were exploited. These data also suggest that there is no correlation between animal-management practices and the cattle found in royal or private/non-royal burial contexts. The results demonstrate considerable divergence between agro-pastoral models promoted by the state and the realities of day-to-day management practices. The data from Ur suggest that the animals exploited different plant and water sources, and that animals reared in similar ways ended up in different depositional contexts.
Saliva molecular testing bypassing RNA extraction is suitable for monitoring and diagnosing SARS-CoV-2 infection in children
Authors: Alenquer Marta , Milheiro Silva Tiago , Akpogheneta Onome , Ferreira Filipe , Vale-Costa Sílvia , Medina-Lopes Mónica , Batista Frederico , Garcia Ana Margarida , Barreto Vasco M. , Paulino Cathy , Costa João , Sobral João , Diniz-da-Costa Maria , Ladeiro Susana , Corte-Real Rita , Delgado Alves José , Leite Ricardo B. , Demengeot Jocelyne , Rocha Brito Maria João , Amorim Maria João
Published: June 2022

Background

Adults are being vaccinated against SARS-CoV-2 worldwide, but the longitudinal protection of these vaccines is uncertain, given the ongoing appearance of SARS-CoV-2 variants. Children remain largely unvaccinated and are susceptible to infection, with studies reporting that they actively transmit the virus even when asymptomatic, thus affecting the community.

Methods

We investigated if saliva is an effective sample for detecting SARS-CoV-2 RNA and antibodies in children, and associated viral RNA levels to infectivity. For that, we used a saliva-based SARS-CoV-2 RT-qPCR test, preceded or not by RNA extraction, in 85 children aged 10 years and under, admitted to the hospital regardless of COVID-19 symptomatology. Amongst these, 29 (63.0%) presented at least one COVID-19 symptom, 46 (54.1%) were positive for SARS-CoV-2 infection, 28 (32.9%) were under the age of 1, and the mean (SD) age was 3.8 (3.4) years. Saliva samples were collected up to 48 h after a nasopharyngeal swab-RT-qPCR test.

Results

In children aged 10 years and under, the sensitivity, specificity, and accuracy of saliva-RT-qPCR tests compared to NP swab-RT-qPCR were, respectively, 84.8% (71.8%–92.4%), 100% (91.0%–100%), and 91.8% (84.0%–96.6%) with RNA extraction, and 81.8% (68.0%–90.5%), 100% (91.0%–100%), and 90.4% (82.1%–95.0%) without RNA extraction. Rescue of infectious particles from saliva was limited to CT values below 26. In addition, we found significant IgM positive responses to SARS-CoV-2 in children positive for SARS-CoV-2 by NP swab and negative by saliva compared to other groups, indicating late infection onset (>7–10 days).

Conclusions

Saliva is a suitable sample type for diagnosing children aged 10 years and under, including infants aged <1 year, even bypassing RNA extraction methods. Importantly, the detected viral RNA levels were significantly above the infectivity threshold in several samples. Further investigation is required to correlate SARS-CoV-2 RNA levels to viral transmission.
Inclusive and active pedagogies reduce academic outcome gaps and improve long-term performance
Authors: Dewsbury Bryan M. , Swanson Holly J. , Moseman-Valtierra Serena , Caulkins Joshua
Published: June 2022

We assessed the impacts of the implementation of inclusive and active pedagogical approaches in an introductory biology sequence at a large, public research university in the northeast United States. We compared academic performance between these sections with other sections of the same course where didactic approaches were used over a five-year period. We also compared this five-year period (2014–2018) with the previous five years of the same courses. Additionally, we also tracked the academic performance of the students from the sections where active learning and inclusive teaching were used, as well as the more conventionally taught (lecture-based) sections in future, mandatory biology courses. We found that the inclusively taught section of the first semester of introductory biology increased the odds of students earning higher grades in that particular section. The active learning section in the second semester narrowed the ethnic performance gap when compared to similar sections, both historically and those run concurrently. Finally, students who matriculated into the inclusively taught section of biology in the first semester followed by the active learning section in the second semester of introductory biology performed better in 200-level biology courses than students who had zero semesters of either active or inclusive pedagogy in their introductory year. Our results suggest that active and inclusive pedagogies hold great promise for improving academic performance when compared to didactic approaches, however, questions remain on the most appropriate ways for capturing the impact of inclusive approaches. Implications for institutional approaches and policy are also discussed.
Investigation into owner-reported differences between dogs born in versus imported into Canada
Authors: von Rentzell Kai Alain , van Haaften Karen , Morris Amy , Protopopova Alexandra
Published: June 2022

Over 1 million dogs are imported into the United States and roughly 340,000 dogs into the United Kingdom yearly. Although the official number of dogs arriving to Canada is currently unknown, local animal professionals estimate that thousands of dogs are imported into Canada each year. Dog importation may be increasing globally while regulation and surveillance are still limited, resulting in concerns for the health and welfare of imported dogs. To date, few studies have investigated how the source location of dogs influences the owner-dog relationship. The current report presents two independent studies that were conducted to assess whether owners of imported dogs reported a poorer owner-dog relationships compared to owners of Canadian-born dogs. In both studies, an online survey was distributed to dog owners (Study 1: n = 803; Study 2: n = 878) in British Columbia, Canada, containing questions on various aspects of the owner-dog relationship. The first study included questions from the Lexington Attachment to Pets Scale, Canine Behavioral Assessment and Research Questionnaire, Human-Animal Bond questionnaire, Monash Dog Owner Relationship Scale, and constructed questions about training methods, expectations, and health. The second study was comprised of original questions assessing difficult behaviour, training practices, health, attachment, and perceived level of burden of owning a dog. Both studies found no evidence of a poorer owner-dog relationship in non-Canadian-sourced dogs. In fact, owners of Canadian-sourced dogs used harsh training methods more frequently and had higher expectations for their dog. While no signs of poorer owner-dog relationship in non-Canadian-sourced dogs were found, future research should continue the investigation of age, health, and backgrounds of incoming dogs.
Systematic characterization of the effective constituents and molecular mechanisms of Ardisiae Japonicae Herba using UPLC-Orbitrap Fusion MS and network pharmacology
Authors: Feng Suxiang , Yuan Jie , Zhao Di , Li Rongrong , Liu Xuefang , Tian Yange , Li Jiansheng
Published: June 2022

Objective

Ardisiae Japonicae Herba (AJH), the dried whole herb of Ardisia japonica (Thunb.) Blume [Primulaceae], has been used in treating chronic obstructive pulmonary disease (COPD) in China. However, the material basis and molecular mechanisms of AJH against COPD remain unclear. Therefore, in this study, we attempt to establish a systematic approach to elucidate the material basis and molecular mechanisms through compound identification, network analysis, molecular docking, and experimental validation.

Methods

Ultra-high performance liquid chromatography-Orbitrap Fusion mass spectrometry (UPLC-Orbitrap Fusion MS) was used to characterize the chemical compounds of AJH. The SwissTargetPrediction, String and Metascape databases were selected for network pharmacology analysis, including target prediction, protein-protein interaction (PPI) network analysis, GO and KEGG pathway enrichment analysis. Cytoscape 3.7.2 software was used to construct a component-target-pathway network to screen out the main active compounds. Autodock Vina software was used to verify the affinity between the key compounds and targets. TNF-α-stimulated A549 cell inflammation model was built to further verify the anti-inflammatory effects of active compounds.

Results

Altogether, 236 compounds were identified in AJH, including 33 flavonoids, 21 Phenylpropanoids, 46 terpenes, 7 quinones, 27 steroids, 71 carboxylic acids and 31 other compounds. Among them, 41 compounds were selected as the key active constituents, which might exhibit therapeutic effects against COPD by modulating 65 corresponding targets primarily involved in inflammation/metabolism/immune-related pathways. The results of molecular docking showed that the key compounds could spontaneously bind to the receptor proteins with a strong binding ability. Finally, the anti-inflammatory effects of the three active compounds were validated with the decreased levels of Interleukin-6 (IL-6) and Matrix Metalloproteinase 9 (MMP9) in TNF-α-induced A549 cells model.

Conclusion

This study clarified that AJH may exert therapeutic actions for COPD via regulating inflammation/immune/metabolism-related pathways using UPLC-Orbitrap Fusion MS technology combined with network pharmacology for the first time. This study had a deeper exploration of the chemical components and pharmacological activities in AJH, which provided a reference for the further study and clinical application of AJH in the treatment of COPD.
Information and communications technology, health, and gender equality: Empirical evidence from a panel of Pacific developing economies
Authors: Makun Keshmeer , Singh Rup , Lal Sumeet , Chand Ronal
Published: June 2022

Information and communications technology (ICT) has been widely embraced in many developing economies in recent times. Extant research reveals that ICT increases economic growth. Beyond economic growth, improved access to information, markets and economic opportunities via information and communications technology have the potential to influence other dimensions of public welfare. This study quantitatively examines the effects of ICT on selected health and gender dimensions of Pacific Island developing countries’ populations. The results show a statistically significant and positive impact of ICT on health and gender outcomes. Our results are robust with an alternative modeling approach, different control variables, and different measures of health and gender outcomes. We further establish that the health outcome of technology has a valid pass-through of income. The study suggests policy implications for the Pacific and other developing countries striving to enhance the health and gender outcomes of SGDs.
Clinical impact of statin intensity according to age in patients with acute myocardial infarction
Authors: Lee Kyusup , Lee Myunhee , Kim Dae-Won , Kim Jinseob , Lim Sungmin , Choo Eun Ho , Kim Chan Joon , Park Chul Soo , Kim Hee Yeol , Yoo Ki-Dong , Jeon Doo Soo , Chang Kiyuk , Youn Ho Joong , Chung Wook-Sung , Kim Min Chul , Jeong Myung Ho , Ahn Youngkeun , Kwon Jongbum , Park Mahn-Won
Published: June 2022

Background

The available data are not sufficient to understand the clinical impact of statin intensity in elderly patients who undergo percutaneous coronary intervention (PCI) due to acute myocardial infarction (AMI).

Methods

Using the COREA-AMI registry, we sought to compare the clinical impact of high- versus low-to-moderate-intensity statin in younger (<75 years old) and elderly (≥75 years old) patients. Of 10,719 patients, we included 8,096 patients treated with drug-eluting stents. All patients were classified into high-intensity versus low-to-moderate-intensity statin group according to statin type and dose at discharge. The primary end point was target-vessel failure (TVF), a composite of cardiovascular death, target-vessel MI, or target-lesion revascularization (TLR) from 1 month to 12 months after index PCI.

Results

In younger patients, high-intensity statin showed the better clinical outcomes than low-to-moderate-intensity statin (TVF: 79 [5.4%] vs. 329 [6.8%], adjusted hazard ratio [aHR] 0.76; 95% confidence interval [CI] 0.59–0.99; P = 0.038). However, in elderly patients, the incidence rates of the adverse clinical outcomes were similar between two statin-intensity groups (TVF: 38 [11.4%] vs. 131 [10.6%], aHR 1.1; 95% CI 0.76–1.59; P = 0.63).

Conclusions

In this AMI cohort underwent PCI, high-intensity statin showed the better 1-year clinical outcomes than low-to-moderate-intensity statin in younger patients. Meanwhile, the incidence rates of adverse clinical events between high- and low-to-moderate-intensity statin were not statistically different in elderly patients. Further randomized study with large elderly population is warranted.
Oral health knowledge, practice, and oral health status among rohingya refugees in Cox’s Bazar, Bangladesh: A cross-sectional study
Authors: Chowdhury Sreshtha , Roy Simanta , Hasan Mehedi , Sadique Asif Al , Islam Tariful , Hasan Mehedi , Arafat Md. Yeasin , Bhuiyan Md. Atiqur Rahman , Islam A. M. Khairul , Khalid Omar , Maliha Ramisha , Hossain Mohammad Ali , Rahman Mohammad Lutfor , Nabi Mohammad Hayatun , Hawlader Mohammad Delwer Hossain
Published: June 2022

Oral health is a critical component of human health but is sometimes forgotten, particularly during humanitarian crises. This research aimed to ascertain the state of oral health among Rohingya refugees living in one of the largest refugee camps and evaluate their knowledge and practice of oral health. A multicenter cross-sectional survey was conducted among 477 participants from July to September 2021 using a structured questionnaire. There were 34 Rohingya camps and out of those 14 camps were accessible for data collection. The study participants were between 18–82 years residing in the refugee camps under Cox’s Bazar. The majority of participants (53.88%) were female and between the ages of 25 and 45. Around 46.12% of respondents did not have basic oral health knowledge, while 53.67% were in need of dental care. Nearly half of the participants demonstrated poor oral health practices. Participants’ age and educational level were positively associated with oral health knowledge (p = 0.02 and p<0.001). Furthermore, the knowledge level was positively associated with oral health practice (p = .025). Participants with a history of teeth pain and discomfort in the last 12 months were ten times more likely to seek treatment (OR = 9.93, CI: 5.591–17.64). The study indicated a growing demand for dental care among Rohingya refugees staying in Bangladesh. To reduce the severity of oral health issues, use of minimally invasive restorative procedures can be suggested in camps. New oral health promotion campaigns should be emphasized and proper education, ideally in their original language, can be beneficial.
The mental health and wellbeing of spouses, partners and children of emergency responders: A systematic review
Authors: Sharp Marie-Louise , Solomon Noa , Harrison Virginia , Gribble Rachael , Cramm Heidi , Pike Graham , Fear Nicola T.
Published: June 2022

Emergency responders (ERs), often termed First Responders, such as police, fire and paramedic roles are exposed to occupational stressors including high workload, and exposure to trauma from critical incidents, both of which can affect their mental health and wellbeing. Little is known about the impact of the ER occupation on the mental health and wellbeing of their families. The aim of the current study was to investigate what mental health and wellbeing outcomes and experiences have been researched internationally in ER families, and to examine the prevalence and associated risk and protective factors of these outcomes. We conducted a systematic review in accordance with an a priori PROSPERO approved protocol (PROSPERO 2019 CRD42019134974). Forty-three studies were identified for inclusion. The majority of studies used a quantitative, cross-sectional design and were conducted in the United States; just over half assessed police/law enforcement families. Themes of topics investigated included: 1) Spousal/partner mental health and wellbeing; 2) Couple relationships; 3) Child mental health and wellbeing; 4) Family support and coping strategies; and 5) Positive outcomes. The review identified limited evidence regarding the prevalence of mental health and wellbeing outcomes. Family experiences and risk factors described were ER work-stress spillover negatively impacting spousal/partner wellbeing, couple relationships, and domestic violence. Traumatic exposure risk factors included concerns family had for the safety of their ER partner, the negative impact of an ER partners’ mental health problem on the couples’ communication and on family mental health outcomes. Protective factors included social support; however, a lack of organisational support for families was reported in some studies. Study limitations and future research needs are discussed. Progressing this area of research is important to improve knowledge of baseline needs of ER families to be able to target interventions, improve public health, and support ER’s operational effectiveness.
Pivotal role of micro-CT technology in setting up an optimized lung fibrosis mouse model for drug screening
Authors: Khalajzeyqami Zahra , Grandi Andrea , Ferrini Erica , Ravanetti Francesca , Leo Ludovica , Mambrini Martina , Giardino Luciana , Villetti Gino , Stellari Franco Fabio
Published: June 2022

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with no curative pharmacological treatment. The most used animal model of IPF for anti-fibrotic drug screening is bleomycin (BLM)-induced lung fibrosis. However, several issues have been reported: the balance among disease resolution, an appropriate time window for therapeutic intervention and animal welfare remain critical aspects yet to be fully elucidated. In this study, C57Bl/6 male mice were treated with BLM via oropharyngeal aspiration (OA) following either double or triple administration. The fibrosis progression was longitudinally assessed by micro-CT every 7 days for 4 weeks after BLM administration. Quantitative micro-CT measurements highlighted that triple BLM administration was the ideal dose regimen to provoke sustained lung fibrosis up to 28 days. These results were corroborated with lung histology and Bronchoalveolar Lavage Fluid cells. We have developed a mouse model with prolonged lung fibrosis enabling three weeks of a curative therapeutic window for the screening of putative anti-fibrotic drugs. Moreover, we have demonstrated the pivotal role of longitudinal micro-CT imaging in reducing the number of animals required per experiment in which each animal can be its own control. This approach permits a valuable decrease in costs and time to develop disease animal models.
Fedor Bondarchuk: 'Stalingrad'
Authors: Norris Stephen
Published: June 2022

KinoSputniks closely analyse some key films from the history of Russian and Soviet cinema. Written by international experts in the field, they are intended for film enthusiasts and students, combining scholarship with an accessible style of writing.

This KinoSputnik about Fedor Bondarchuk's megahit Stalingrad (2013) examines the production, context and reception of the film, whilst offering a detailed reading of its key themes.

Fedor Bondarchuk’s 2013 blockbuster film Stalingrad shattered box-office records and dazzled viewers with its use of special effects, enhanced by its 3D IMAX format. The film transported viewers back to 1942 and the bloody battle that would turn the tide of the Second World War.

This new study situates the film within the context of ongoing debates about the meanings of the Second World War in Russia and previous films about the Battle of Stalingrad.

Primary readership will be among film studies students and film enthusiasts, but will also be of interest to anyone researching or studying the Battle of Stalingrad and the course of the Second World War.

A list of all books in the series is here on the Intellect website on the series page KinoSputnik
Aleksei Balabanov: 'Brother'
Authors: Osterberg Ira
Published: June 2022

KinoSputniks closely analyse some key films from the history of Russian and Soviet cinema. Written by international experts in the field, they are intended for film enthusiasts and students, combining scholarship with an accessible style of writing.

Ira Österberg's KinoSputnik on Aleksei Balabanov's cult film Brother (1997) examines the production history, context and reception of the film, and offers a detailed reading of its key themes.

Balabanov’s Brother made a mark on the new Russia’s film history as its hero Danila Bagrov quickly gained cult status and the nostalgic rock soundtrack hit the nerve of the young post-Soviet generation. This study unravels the film’s effective and ingenious mixture of genre elements, art narration and almost documentary-style realism, which would become trademarks for Balabanov’s oeuvre.

Primary readership will be among film studies students and film enthusiasts, but will also be of interest to anyone researching or studying film soundtracking.

A list of all books in the series is here on the Intellect website on the series page KinoSputnik