bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Adding Indirect Relationship to Turbo Similarity Searching
Authors: Malim Nurul H. A. Hassain , Pei-Chia Yong , Al-Laila Marwah H. , Arif Shereena M.
Published: June 2016

Background:

Turbo Similarity Searching (TSS) has been proved as one of the effective and simple searching method in Cheminformatics. Emerging from the conventional similarity searching, TSS depended on the concept of fusion where relationship between the target being sought and the compound in the database are indirect. Previous works has looked at only one level of indirect relationship and indicates that there are further potential that more levels of such relationship be added to TSS to increase its ability to recover more actives. Hence, in this work, we aimed to investigate the impact of the indirect relationship on TSS.

Method:

This study has further investigated the enhancement of TSS using additional layers of indirect relationship and fusion process. We implemented TSS by adding another layer of fusion between the target and database compound.

Results:

The experiments with MDDR database showed that the proposed new strategy described in this paper provide a way of enhancing the effectiveness of the TSS process in chemical databases. The experiments also showed that the increases in performance are particularly better when the sought actives are structurally diverse.

Conclusion:

We may conclude that the additional layers do increase the recall of TSS. Hence, the new TSS strategy could be used as an alternative to the old TSS.
Flakes product supplemented with sunflower and dry residues of wild oregano
Authors: Kosutic Milenko , Filipovic Jelena , Njezic Zvonko , Filipovic Vladimir , Filipovic Vladimir , Blagojevic Bojana
Published: June 2016

This paper investigates the effects of simultaneous addition of sunflower (3, 6 or 9 g/100 g of sample) and dry residue of wild oregano (0.5 or 1 of sample), on the physical texture and chemical properties of corn flakes to obtain new products with altered nutritional properties. The chemometric analysis pointed at the versatile beneficial contributions of sunflower in corn flakes enriched with dry residue of wild oregano enabling the optimization of corn flakes formula. The presented data point that addition of milled sunflower in investigated corn flakes products improved nutritive properties while addition of dry residue of wild oregano improved physical characteristics of corn flakes products. Regarding quality (sample CF11, score value of 0.59) maximum scores have been obtained with the addition of 6 g/100 g of sunflower and 1 g/100 g of dry residue of wild oregano per 100 g of sample for corn flakes formulation. Production of corn flakes with addition of wild oregano residues contributed to the food waste valorisation in the food industry.
Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties
Authors: Kuda Ondrej , Brezinova Marie , Rombaldova Martina , Slavikova Barbora , Posta Martin , Beier Petr , Janovska Petra , Veleba Jiri , Kopecky Jan , Kudova Eva , Pelikanova Terezie , Kopecky Jan
Published: June 2016

White adipose tissue (WAT) is a complex organ with both metabolic and endocrine functions. Dysregulation of all of these functions of WAT, together with low-grade inflammation of the tissue in obese individuals, contributes to the development of insulin resistance and type 2 diabetes. n-3 polyunsaturated fatty acids (PUFAs) of marine origin play an important role in the resolution of inflammation and exert beneficial metabolic effects. Using experiments in mice and overweight/obese patients with type 2 diabetes, we elucidated the structures of novel members of fatty acid esters of hydroxy fatty acids—lipokines derived from docosahexaenoic acid (DHA) and linoleic acid, which were present in serum and WAT after n-3 PUFA supplementation. These compounds contained DHA esterified to 9- and 13-hydroxyoctadecadienoic acid (HLA) or 14-hydroxydocosahexaenoic acid (HDHA), termed 9-DHAHLA, 13-DHAHLA, and 14-DHAHDHA, and were synthesized by adipocytes at concentrations comparable to those of protectins and resolvins derived from DHA in WAT. 13-DHAHLA exerted anti-inflammatory and proresolving properties while reducing macrophage activation by lipopolysaccharides and enhancing the phagocytosis of zymosan particles. Our results document the existence of novel lipid mediators, which are involved in the beneficial anti-inflammatory effects attributed to n-3 PUFAs, in both mice and humans.
Once-Daily Liraglutide Versus Lixisenatide as Add-on to Metformin in Type 2 Diabetes: A 26-Week Randomized Controlled Clinical Trial
Authors: Nauck Michael , Rizzo Manfredi , Johnson Andrew , Bosch-Traberg Heidrun , Madsen Jesper , Cariou Bertrand
Published: June 2016

OBJECTIVE

To compare the efficacy and safety of liraglutide versus lixisenatide as add-on to metformin in patients with type 2 diabetes not achieving adequate glycemic control on metformin alone.

RESEARCH DESIGN AND METHODS

In this 26-week, randomized, parallel-group, open-label trial, 404 patients were randomized 1:1 to liraglutide 1.8 mg or lixisenatide 20 µg as add-on to metformin. Liraglutide was administered once daily at any time of the day. Lixisenatide was administered once daily within 1 h prior to the morning or evening meal.

RESULTS

At week 26, liraglutide reduced HbA1c (primary end point) more than lixisenatide (estimated treatment difference −0.62% [95% CI −0.8; −0.4]; P < 0.0001), with more patients reaching HbA1c <7% (53 mmol/mol) and ≤6.5% (48 mmol/mol) versus lixisenatide (74.2% and 54.6% for liraglutide vs. 45.5% and 26.2% for lixisenatide; P < 0.0001 for both). Liraglutide reduced fasting plasma glucose more than lixisenatide (estimated treatment difference −1.15 mmol/L [95% CI −1.5; −0.8]; P < 0.0001). Liraglutide provided greater reduction in mean 9-point self-measured plasma glucose (P < 0.0001). However, postprandial glucose increments were smaller with lixisenatide for the meal directly after injection compared with liraglutide (P < 0.05), with no differences between treatments across all meals. Both drugs promoted similar body weight decrease (−4.3 kg for liraglutide, −3.7 kg for lixisenatide; P = 0.23). The most common adverse events in both groups were gastrointestinal disorders. Greater increases in pulse, lipase, and amylase were observed with liraglutide. Hypoglycemic episodes were rare and similar between the two treatments.

CONCLUSIONS

At the dose levels studied, liraglutide was more effective than lixisenatide as add-on to metformin in improving glycemic control. Body weight reductions were similar. Both treatments were well tolerated, with low risk of hypoglycemia and similar gastrointestinal adverse event profiles.
Durability of Addition of Roux-en-Y Gastric Bypass to Lifestyle Intervention and Medical Management in Achieving Primary Treatment Goals for Uncontrolled Type 2 Diabetes in Mild to Moderate Obesity: A Randomized Control Trial
Authors: Ikramuddin Sayeed , Korner Judith , Lee Wei-Jei , Bantle John P. , Thomas Avis J. , Connett John E. , Leslie Daniel B. , Inabnet William B. , Wang Qi , Jeffery Robert W. , Chong Keong , Chuang Lee-Ming , Jensen Michael D. , Vella Adrian , Ahmed Leaque , Belani Kumar , Olofson Amy E. , Bainbridge Heather A. , Billington Charles J.
Published: June 2016

OBJECTIVE

We compared 3-year achievement of an American Diabetes Association composite treatment goal (HbA1c <7.0%, LDL cholesterol <100 mg/dL, and systolic blood pressure <130 mmHg) after 2 years of intensive lifestyle-medical management intervention, with and without Roux-en-Y gastric bypass, with one additional year of usual care.

RESEARCH DESIGN AND METHODS

A total of 120 adult participants, with BMI 30.0–39.9 kg/m2 and HbA1c ≥8.0%, were randomized 1:1 to two treatment arms at three clinical sites in the U.S. and one in Taiwan. All patients received the lifestyle-medical management intervention for 24 months; half were randomized to also receive gastric bypass.

RESULTS

At 36 months, the triple end point goal was met in 9% of lifestyle-medical management patients and 28% of gastric bypass patients (P = 0.01): 10% and 19% lower than at 12 months. Mean (SD) HbA1c values at 3 years were 8.6% (3.5) and 6.7% (2.0) (P < 0.001). No lifestyle-medical management patient had remission of diabetes at 36 months, whereas 17% of gastric bypass patients had full remission and 19% had partial remission. Lifestyle-medical management patients used more medications than gastric bypass patients: mean (SD) 3.8 (3.3) vs. 1.8 (2.4). Percent weight loss was mean (SD) 6.3% (16.1) in lifestyle-medical management vs. 21.0% (14.5) in gastric bypass (P < 0.001). Over 3 years, 24 serious or clinically significant adverse events were observed in lifestyle-medical management vs. 51 with gastric bypass.

CONCLUSIONS

Gastric bypass is more effective than lifestyle-medical management intervention in achieving diabetes treatment goals, mainly by improved glycemic control. However, the effect of surgery diminishes with time and is associated with more adverse events.
Increased Risk of Incident Chronic Kidney Disease, Cardiovascular Disease, and Mortality in Patients With Diabetes With Comorbid Depression
Authors: Novak Marta , Mucsi Istvan , Rhee Connie M. , Streja Elani , Lu Jun L. , Kalantar-Zadeh Kamyar , Molnar Miklos Z. , Kovesdy Csaba P.
Published: June 2016

OBJECTIVE

It is not known if patients with diabetes with depression have an increased risk of chronic kidney disease (CKD). We examined the association between depression and incident CKD, mortality, and incident cardiovascular events in U.S. veterans with diabetes.

RESEARCH DESIGN AND METHODS

Among a nationally representative prospective cohort of >3 million U.S. veterans with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2, we identified 933,211 patients with diabetes. Diabetes was ascertained by an ICD-9-CM code for diabetes, an HbA1c >6.4%, or receiving antidiabetes medication during the inclusion period. Depression was defined by an ICD-9-CM code for depression or by antidepressant use during the inclusion period. Incident CKD was defined as two eGFR levels <60 mL/min/1.73 m2 separated by ≥90 days and a >25% decline in baseline eGFR. The associations between depression and outcomes were assessed using Cox proportional regression.

RESULTS

Depression was present in 340,806 patients at enrollment. Depressed patients were younger (61 ± 11 vs. 65 ± 11 years), had higher eGFR (84 ± 15 vs. 81 ± 14 mL/min/1.73 m2), but had more comorbidities. Incident CKD developed in 180,343 patients. Depression was associated with 20% higher risk of incident CKD (adjusted hazard ratio [aHR] and 95% CI: 1.20 [1.19–1.21]). Similarly, depression was associated with increased all-cause mortality (aHR and 95% CI: 1.25 [1.24–1.26]).

CONCLUSIONS

The presence of depression in patients with diabetes is associated with higher risk of developing CKD compared with nondepressed patients. Intervention studies should determine if effective treatment of depression in patients with diabetes would prevent major renal and cardiovascular complications.
Education Research in Physical Therapy: Visions of the Possible
Authors: Jensen Gail M. , Nordstrom Terrence , Segal Richard L. , McCallum Christine , Graham Cecilia , Greenfield Bruce
Published: June 2016

Education research has been labeled the “hardest science” of all, given the challenges of teaching and learning in an environment encompassing a mixture of social interactions, events, and problems coupled with a persistent belief that education depends more on common sense than on disciplined knowledge and skill. The American Educational Research Association specifies that education research—as a scientific field of study—examines teaching and learning processes that shape educational outcomes across settings and that a learning process takes place throughout a person's life. The complexity of learning and learning environments requires not only a diverse array of research methods but also a community of education researchers committed to exploring critical questions in the education of physical therapists. Although basic science research and clinical research in physical therapy have continued to expand through growth in the numbers of funded physical therapist researchers, the profession still lacks a robust and vibrant community of education researchers. In this perspective article, the American Council of Academic Physical Therapy Task Force on Education Research proposes a compelling rationale for building a much-needed foundation for education research in physical therapy, including a set of recommendations for immediate action.
Outbreak of diarrhoeal illness in participants in an obstacle adventure race, Alpes-Maritimes, France, June 2015
Authors: Six Caroline , Aboukais Samer , Giron Sandra , D’Oliveira Jean-Christophe , Peloux-Petiot Françoise , Franke Florian , Terrien Hervé , Dassonville Fabrice , Deniau Joël , Ambert-Balay Katia , Chesnot Thierry , Ruimy Raymond , Pélandakis Michel , Basset Patrick , Munoz Rivero Manuel , Malfait Philippe
Published: June 2016

An acute gastroenteritis (AG) outbreak occurred among participants in an obstacle race in France in the summer of 2015. An investigation in two phases was conducted to identify the source of infection and document the extent of the outbreak. First, a message on a social media website asked racers to report any symptoms by email to the Regional Health Agency of Provence-Alpes-Côte d’Azur. Second, a retrospective cross-sectional study was conducted through an interactive questionnaire for all participants, followed by an analytical study of potential risks factors. Of 8,229 persons registered, 1,264 adults reported AG resolved within 48 hours. Of adults who reported AG, 866 met the case definition. Age group, departure time and ingestion of mud were associated with AG. Twenty stool specimens tested negative for bacteria. All four stool samples tested for viruses were positive for norovirus genogroup I and genotype 2. No indicator bacteria for faecal contamination were found in drinking water but muddy water of ponds tested positive. The outbreak was possibly caused by human-to-human transmission of a norovirus introduced by one or more persons and transmitted through contaminated mud. Risks related to similar races should be assessed and recommendations be proposed to raise awareness among health authorities and organisers.
The Theoretical and Empirical Basis of Teacher Leadership
Authors: Wenner Julianne A. , Campbell Todd
Published: June 2016

In the current review, we examined teacher leadership research completed since York-Barr and Duke published the seminal review on teacher leadership in 2004. The review was undertaken to examine how teacher leadership is defined, how teacher leaders are prepared, their impact, and those factors that facilitate or inhibit teacher leaders’ work. Beyond this, the review considered theories informing teacher leadership, teacher leadership within disciplinary contexts, and the roles of teacher leaders in social justice and equity issues. The most salient findings were (a) teacher leadership, although rarely defined, focused on roles beyond the classroom, supporting the professional learning of peers, influencing policy/decision making, and ultimately targeting student learning; (b) the research is not always theoretically grounded; (c) principals, school structures, and norms are important in empowering or marginalizing teacher leaders; and (d) very little teacher leadership research examines issues of social justice and equity.
Race, Street Life, and Policing: Implications for Racial Profiling
Authors: Hayle Steven , Wortley Scot , Tanner Julian
Published: June 2016

Scholarship is divided over whether youth from marginalized populations are stopped and searched by police primarily due to their illegal behaviours (functionalism), marginalized status (conflict theory), or both. We address this debate by comparing the police interactions experienced by a sample of high school students (N = 3,393) living at home with a sample of youth (N = 396) who have left home and are residing in shelters or on the streets of Toronto, Ontario. Logistic regression analysis demonstrates that after controlling for demographic and behavioural factors, black high school students are more likely than white high school students to report being stopped and searched by the police multiple times; this indicates that they are the victims of racially biased policing. In contrast, black and white street youth are equally likely to report being stopped and searched by the police on multiple occasions. We suggest that this is because all street youth, regardless of race, take part in high levels of deviant behaviour, which attracts police attention. We conclude that consensus theory is appropriate for explaining police stops and searches of street youth, whereas conflict theory is appropriate for explaining police stops and searches of black high school students.
Les relations interorganisationnelles déséquilibrées au sein de l’usine mondiale
Authors: Melin Christopher , Mayrhofer Ulrike
Published: June 2016

Cet article porte sur les relations interorganisationnelles des firmes multinationales. Les auteurs s’attachent à identifier les relations déséquilibrées qui peuvent s’opérer au sein de systèmes de production sans frontières. L’étude empirique a été réalisée auprès de l’entreprise Renault Trucks (groupe Volvo) et ses partenaires internationaux. L’analyse proposée met en relief les enjeux liés aux relations interorganisationnelles verticales. Elle montre comment ces relations peuvent être pilotées et coordonnées dans le cadre de l’usine mondiale.
Asymétries partenariales et performance des co-entreprises
Authors: Dikmen Laure , Cheriet Foued
Published: June 2016

Cet article a pour ambition d’étudier la performance des coentreprises internationales dans un contexte d’asymétrie structurelle, géographique et culturelle, entre des partenaires issus de pays émergents et de pays développés. Cette recherche examine la performance perçue du parent local turc depuis la création de son entité commune. Par ailleurs l’asymétrie, traditionnellement étudiée à travers le différentiel de taille entre les partenaires, est analysée en incluant les critères d’effectif, de chiffre d’affaires, de taux de croissance, de clientèle, de prise de décision et position concurrentielle pour définir la notion de l’asymétrie partenariale. Notre étude a ainsi permis une analyse plus fine des différentes dimensions de l’asymétrie partenariale et de ses effets sur la performance des co-entreprises internationales.
L’impact des pratiques de formation sur la légitimité de la GRH
Authors: Alves Sarah , Frih Sophia
Published: June 2016

Cet article à pour objectif de savoir si la personnalisation de la gestion de la formation impacte positivement la légitimité des RH en comparant les pratiques de formation de deux établissements, leur stratégie de personnalisation et le regard porté par les acteurs internes sur ces pratiques. Les résultats de cette étude montrent que la légitimité est en lien très étroit avec la culture interne mais son mécanisme semble répondre à un double jugement selon deux systèmes de référence distincts. De là, les auteurs proposent dans quel contexte adopter une stratégie de personnalisation plutôt qu’une autre.
Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature
Authors: Pricola Fehnel Katie , Duggins-Warf Micah , Zurakowski David , McKee-Proctor Maxwell , Majumder Rajarshi , Raber Michael , Han Xuezhe , Smith Edward R.
Published: June 2016

OBJECTIVE

The authors report the use of urinary biomarkers as a novel, noninvasive technique to detect juvenile pilocytic astrocytomas (JPAs), capable of distinguishing JPAs from other CNS diseases, including other brain tumors. Preliminary screening of an array of tumors implicated proteases (including matrix metalloproteinases [MMPs]) and their inhibitors (tissue inhibitors of metalloproteinase [TIMPs]) as well as growth factors (including basic fibroblast growth factor [bFGF]) as candidate biomarkers. These data led the authors to hypothesize that tissue inhibitor of metalloproteinase 3 (TIMP3) and bFGF would represent high-probability candidates as JPA-specific biomarkers.

METHODS

Urine was collected from 107 patients, which included children with JPA (n = 21), medulloblastoma (n = 17), glioblastoma (n = 9), arteriovenous malformations (n = 25), moyamoya (n = 14), and age- and sex-matched controls (n = 21). Biomarker levels were quantified with enzyme-linked immunosorbent assay, tumor tissue expression was confirmed with immunohistochemical analysis, and longitudinal biomarker expression was correlated with imaging. Results were subjected to univariate and multivariate statistical analyses.

RESULTS

Using optimal urinary cutoff values of bFGF > 1.0 pg/μg and TIMP3 > 3.5 pg/μg, multiplexing bFGF and TIMP3 predicts JPA presence with 98% accuracy. Multiplexing bFGF and MMP13 distinguishes JPA from other brain tumor subtypes with up to 98% accuracy. Urinary biomarker expression correlated with both tumor immunohistochemistry and in vitro tumor levels. Urinary bFGF and TIMP3 decrease following successful tumor treatment and correlate with changes in tumor size.

CONCLUSIONS

This study identifies 2 urinary biomarkers—bFGF and TIMP3—that successfully detect one of the most common pediatric brain tumors with high accuracy. These data highlight potential benefits of urinary biomarkers and support their utility as diagnostic tools in the treatment of children with JPA.
Accuracy of operating neurosurgeons' prediction of functional levels after intracranial tumor surgery
Authors: Sagberg Lisa Millgård , Drewes Christina , Jakola Asgeir S. , Solheim Ole
Published: June 2016

OBJECTIVE

In the absence of practical and reliable prognostic tools in intracranial tumor surgery, decisions regarding patient selection, patient information, and surgical management are usually based on neurosurgeons' clinical judgment, which may be influenced by personal experience and knowledge. The objective of this study was to assess the accuracy of the operating neurosurgeons' predictions about patients' functional levels after intracranial tumor surgery.

METHODS

In a prospective single-center study, the authors included 299 patients who underwent intracranial tumor surgery between 2011 and 2015. The operating neurosurgeons scored their patients' expected functional level at 30 days after surgery using the Karnofsky Performance Scale (KPS). The expected KPS score was compared with the observed KPS score at 30 days.

RESULTS

The operating neurosurgeons underestimated their patients' future functional level in 15% of the cases, accurately estimated their functional levels in 23%, and overestimated their functional levels in 62%. When dichotomizing functional levels at 30 days into dependent or independent functional level categories (i.e., KPS score < 70 or ≥ 70), the predictive accuracy was 80%, and the surgeons underestimated and overestimated in 5% and 15% of the cases, respectively. In a dichotomization based on the patients' ability to perform normal activities (i.e., KPS score < 80 or ≥ 80), the predictive accuracy was 57%, and the surgeons underestimated and overestimated in 3% and 40% of cases, respectively. In a binary regression model, the authors found no predictors of underestimation, whereas postoperative complications were an independent predictor of overestimation (p = 0.01).

CONCLUSIONS

Operating neurosurgeons often overestimate their patients' postoperative functional level, especially when it comes to the ability to perform normal activities at 30 days. This tendency to overestimate surgical outcomes may have implications for clinical decision making and for the accuracy of patient information.
Establishment and characterization of a chordoma cell line from the tissue of a patient with dedifferentiated-type chordoma
Authors: Kim Jeong-Yub , Lee Jongsun , Koh Jae-Soo , Park Myung-Jin , Chang Ung-Kyu
Published: June 2016

OBJECTIVE

Chordoma is a rare bone tumor of the axial skeleton believed to originate from the remnants of the embryonic notochord. The available tumor cells are characteristically physaliferous and express brachyury, a transcription factor critical for mesoderm specification. Although chordomas are histologically not malignant, treatments remain challenging because they are resistant to radiation therapy and because wide resection is impossible in most cases. Therefore, a better understanding of the biology of chordomas using established cell lines may lead to the advancement of effective treatment strategies. The authors undertook a study to obtain this insight.

METHODS

Chordoma cells were isolated from the tissue of a patient with dedifferentiated-type chordoma (DTC) that had recurred. Cells were cultured with DMEM/F12 containing 10% fetal bovine serum and antibiotics (penicillin and streptomycin). Cell proliferation rate was measured by MTS assay. Cell-cycle distribution and cell surface expression of proteins were analyzed by fluorescence-activated cell sorting (FACS) analysis. Expression of proteins was analyzed by Western blot and immunocytochemistry. Radiation resistance was measured by clonogenic survival assay. Tumor formation was examined by injection of chordoma cells at hindlimb of nude mice.

RESULTS

The putative (DTC) cells were polygonal and did not have the conventional physaliferous characteristic seen in the U-CH1 cell line. The DTC cells exhibited similar growth rate and cell-cycle distribution, but they exhibited higher clonogenic activity in soft agar than U-CH1 cells. The DTC cells expressed high levels of platelet-derived growth factor receptor–β and a low level of brachyury and cytokeratins; they showed higher expression of stemness-related and epithelial to mesenchymal transition–related proteins than the U-CH1 cells. Intriguingly, FACS analysis revealed that DTC cells exhibited marginal surface expression of CD24 and CD44 and high surface expression of CXCR4 in comparison to U-CH1 cells. In addition, blockade of CXCR4 with its antagonist AMD3100 effectively suppressed the growth of both cell lines. The DTC cells were more resistant to paclitaxel, cisplatin, etoposide, and ionizing radiation than the U-CH1 cells. Injection of DTC cells into the hindlimb region of nude mice resulted in the efficient formation of tumors, and the histology of xenograft tumors was very similar to that of the original patient tumor.

CONCLUSIONS

The use of the established DTC cells along with preestablished cell lines of chordoma may help bring about greater understanding of the mechanisms underlying the chordoma that will lead to therapeutic strategies targeting chordomas.
Surgical treatment of degenerative and traumatic spinal diseases with expandable screws in patients with osteoporosis: 2-year follow-up clinical study
Authors: Gazzeri Roberto , Roperto Raffaelino , Fiore Claudio
Published: June 2016

OBJECTIVE

Pedicle screw instrumentation of the osteoporotic spine carries an increased risk of screw loosening, pullout, and fixation failure. A variety of techniques have been used clinically to improve pedicle screw fixation in the presence of compromised bone. Pedicle screws may be augmented with cement, but this may lead to cement leakage and result in disastrous consequences. To avoid these complications, a multiaxial expandable pedicle screw has been developed. This was a prospective, single-center study designed to evaluate the clinical results of patients with osteoporosis with traumatic and degenerative spinal diseases treated with expandable pedicle screws.

METHODS

Thirty-three patients (mean age 61.4 years) with osteoporosis and traumatic or degenerative spinal diseases underwent spinal posterior fixation with expandable screws. Preoperative and postoperative visual analog scale (VAS) for pain and Oswestry Disability Index (ODI) questionnaire scores were obtained. The immediate postoperative screw position was measured and compared with the final position on lateral plain radiographs and axial CT scans at the 1- and 2-year follow-up examinations.

RESULTS

A total of 182 pedicle screws were used, including 174 expandable and 8 regular screws. The mean preoperative patient VAS score improved from 8.2 to 3.6 after surgery. The mean ODI score improved from 83.7% before surgery to 29.7% after the operation and to 36.1% at the final follow-up. No screw migration had occurred at the 1-year follow-up, but 1 screw breakage/migration was visualized on spinal radiography at the 2-year follow-up.

CONCLUSIONS

The results of this study show that the multiaxial expandable pedicle screw is a safe and practical technique for patients with osteoporosis and various spinal diseases and adds a valuable tool to the armamentarium of spinal instrumentation.
Recovery of functional connectivity of the sensorimotor network after surgery for diffuse low-grade gliomas involving the supplementary motor area
Authors: Vassal Matthieu , Charroud Céline , Deverdun Jérémy , Le Bars Emmanuelle , Molino François , Bonnetblanc Francois , Boyer Anthony , Dutta Anirban , Herbet Guillaume , Moritz-Gasser Sylvie , Bonafé Alain , Duffau Hugues , de Champfleur Nicolas Menjot
Published: June 2016

OBJECTIVE

The supplementary motor area (SMA) syndrome is a well-studied lesional model of brain plasticity involving the sensorimotor network. Patients with diffuse low-grade gliomas in the SMA may exhibit this syndrome after resective surgery. They experience a temporary loss of motor function, which completely resolves within 3 months. The authors used functional MRI (fMRI) resting state analysis of the sensorimotor network to investigate large-scale brain plasticity between the immediate postoperative period and 3 months' follow-up.

METHODS

Resting state fMRI was performed preoperatively, during the immediate postoperative period, and 3 months postoperatively in 6 patients with diffuse low-grade gliomas who underwent partial surgical excision of the SMA. Correlation analysis within the sensorimotor network was carried out on those 3 time points to study modifications of its functional connectivity.

RESULTS

The results showed a large-scale reorganization of the sensorimotor network. Interhemispheric connectivity was decreased in the postoperative period, and increased again during the recovery process. Connectivity between the lesion side motor area and the contralateral SMA rose to higher values than in the preoperative period. Intrahemispheric connectivity was decreased during the immediate postoperative period and had returned to preoperative values at 3 months after surgery.

CONCLUSIONS

These results confirm the findings reported in the existing literature on the plasticity of the SMA, showing large-scale modifications of the sensorimotor network, at both inter- and intrahemispheric levels. They suggest that interhemispheric connectivity might be a correlate of SMA syndrome recovery.
Changing of the guard: reducing infection when replacing neural pacemakers
Authors: Pepper Joshua , Meliak Lara , Akram Harith , Hyam Jonathan , Milabo Catherine , Candelario Joseph , Foltynie Thomas , Limousin Patricia , Curtis Carmel , Hariz Marwan , Zrinzo Ludvic
Published: June 2016

OBJECTIVE

Infection of deep brain stimulation (DBS) hardware has a significant impact on patient morbidity. Previous experience suggests that infection rates appear to be higher after implantable pulse generator (IPG) replacement surgery than after the de novo DBS procedure. In this study the authors examine the effect of a change in practice during DBS IPG replacements at their institution.

METHODS

Starting in January 2012, patient screening for methicillin-resistant Staphylococcus aureus (MRSA) and, and where necessary, eradication was performed prior to elective DBS IPG change. Moreover, topical vancomycin was placed in the IPG pocket during surgery. The authors then prospectively examined the infection rate in patients undergoing DBS IPG replacement at their center over a 3-year period with at least 9 months of follow-up.

RESULTS

The total incidence of infection in this prospective consecutive series of 101 IPG replacement procedures was 0%, with a mean follow-up duration of 24 ± 11 months. This was significantly lower than the authors' previously published historical control group, prior to implementing the change in practice, where the infection rate for IPG replacement was 8.5% (8/94 procedures; p = 0.003).

CONCLUSIONS

This study suggests that a change in clinical practice can significantly lower infection rates in patients undergoing DBS IPG replacement. These simple measures can minimize unnecessary surgery, loss of benefit from chronic stimulation, and costly hardware replacement, further improving the cost efficacy of DBS therapies.
Efficacy of microsurgical tumor removal for treatment of patients with intracanalicular vestibular schwannoma presenting with disabling vestibular symptoms
Authors: Samii Madjid , Metwali Hussam , Gerganov Venelin
Published: June 2016

OBJECTIVE

The aim of this study was to analyze the efficacy and risks of microsurgery via the hearing-preserving retrosigmoid approach in patients with intracanalicular vestibular schwannoma (VS) suffering from disabling vestibular symptoms, with special attention to vertigo.

METHODS

This is a retrospective analysis of 19 patients with intracanalicular VS and disabling vestibular dysfunction as the main or only symptom (Group A). All of the patients reported having had disabling vertigo attacks. Subjective evaluation of the impairment of patients was performed before surgery, 3 weeks after surgery, 3 months after surgery, and 1 year after surgery, using the Dizziness Handicap Inventory (DHI). The main outcome measures were improvement in quality of life as measured using the DHI, and general and functional outcomes, in particular facial function and hearing. Patient age, preoperative tumor size, preoperative DHI score, and preservation of the nontumorous vestibular nerve were tested using a multivariate regression analysis to determine factors affecting the postoperative DHI score. The Mann-Whitney U-test was used to compare the postoperative DHI score at 3 weeks, 3 months, and 1 year after surgery with a control group of 19 randomly selected patients with intracanalicular VSs, who presented without vestibular symptoms (Group B). The occurrence of early postoperative discrete vertigo attacks was also compared between groups.

RESULTS

The preoperative DHI score was ≥ 54 in all patients. All patients reported having had disabling rotational vertigo before surgery. The only significant factor to affect the DHI outcome 3 weeks and 3 months after surgery was the preoperative DHI score. The DHI outcome after 1 year was not affected by the preoperative DHI score. Compared with the control group, the DHI score at 3 weeks and 3 months after surgery was significantly worse. There was no significant difference between the groups after 1 year. Vertigo was improved in all patients and completely resolved after 1 year in 17 patients.

CONCLUSIONS

Disabling vestibular dysfunction that affects quality of life should be considered an indication for surgery, even in otherwise asymptomatic patients with intracanalicular VS. Surgical removal of the tumor is safe and very effective in regard to symptom relief. All patients had excellent facial nerve function within 1 year after surgery, with a very good chance of hearing preservation.
Transischiorectal fossa approach for resection of pudendal nerve schwannoma: case report
Authors: Chen Stephanie , Gaynor Brandon , Levi Allan D.
Published: June 2016

Pudendal nerve schwannomas are very rare, with only two cases reported in the English-language literature. The surgical approaches described in these two case reports are the transgluteal approach and the laparoscopic approach. The authors present the case of a patient with progressive pelvic pain radiating ipsilaterally into her groin, vagina, and rectum, who was subsequently found to have a pudendal schwannoma. The authors used a transischiorectal fossa approach and intraoperative electrophysiological monitoring and successfully excised the tumor. This approach has the advantage of direct access to Alcock's canal with minimal disruption of the pelvic muscles and ligaments. The patient experienced complete relief of her pelvic pain after the procedure.
Pathophysiological basis of human papillomavirus in penile cancer: Key to prevention and delivery of more effective therapies
Authors: Spiess Philippe E. , Dhillon Jasreman , Baumgarten Adam S. , Johnstone Peter A. , Giuliano Anna R.
Published: June 2016

Answer questions and earn CME/CNE

Squamous cell carcinoma (SCC) of the penis is a rare malignancy in the United States, with a significantly higher incidence—up to 20 to 30 times greater—in areas of Africa and South America. This can be explained in part by the significantly greater prevalence of sexually transmitted diseases among high‐risk males often having unprotected sex with multiple sexual partners. Human papillomavirus (HPV) has been implicated as the infectious pathway by which several these penile neoplasms originate from precursor lesions. In this regard, a fundamental understanding of HPV in penile carcinogenesis can have meaningful implications in understanding 1) the diagnosis of HPV‐related precursor penile lesions, 2) targeting HPV‐specific molecular pathways, and 3) cancer prevention. Using vaccination programs not only may improve patient outcomes but also may minimize the need for highly aggressive and often debilitating surgical resection. CA Cancer J Clin 2016;66:481–495. © 2016 American Cancer Society.
‘Information and Inspiration’: Wangari Maathai, the Green Belt Movement and Eco-Children's Literature
Authors: Smulders Sharon
Published: June 2016

Starting with seven seedlings in 1977, Wangari Maathai had, by the time of her death in 2011, become a legendary figure in the Green Belt Movement which, in its simplest terms, understands tree planting as fundamental to civic education, political advocacy, community empowerment, economic sustainability and global biodiversity. Taking Maathai's epic stature into consideration, this paper will examine how five picturebook biographies negotiate various eco-pedagogical strategies to encourage environmental awareness in children. Moreover, this paper will not only explore the verbal and visual rhetoric of tree planting but also examine how contemporary children's literature seeks to represent the third world to the first by engaging and promoting issues related to eco-literacy, indigeneity, women's rights and environmental justice.
Rape Scripts and Rape Spaces: Constructions of Female Bodies in Adolescent Fiction
Authors: Altrows Aiyana
Published: June 2016

This article offers an analysis of the construction of female bodies in adolescent fiction about rape, arguing that the absence of a developed rapist character results in a focus on and pathologising of female characters. This positions female bodies as the cause of rape, rather than societal problems or rapists themselves, creating ‘rape spaces’. The positioning of female bodies as the cause of rape sanctions public and state control of those bodies, removing a female's subjective agency and right to manage her own body. I demonstrate how the depiction of psychological relationships to bodies as they develop sexually during puberty and attract unwanted male attention can function within the narrative to undermine a girl's ability to manage her own body, and how female sexual desire can either undermine or reinforce a girl's ability to manage her own body. I analyse how fraught relationships to clothing and food can be either accepted and interpolated to reinforce the construction of female bodies as rape spaces within these texts, or problematised to portray empowered female characters as they recognise and reject them as potential tools of patriarchal control.
The Role of Glucosinolate Hydrolysis Products from Brassica Vegetable Consumption in Inducing Antioxidant Activity and Reducing Cancer Incidence
Authors: Becker Talon , Juvik John
Published: June 2016

The bioactivity of glucosinolates (GSs), and more specifically their hydrolysis products (GSHPs), has been well documented. These secondary metabolites evolved in the order Brassicales as plant defense compounds with proven ability to deter or impede the growth of several biotic challenges including insect infestation, fungal and bacterial infection, and competition from other plants. However, the bioactivity of GSHPs is not limited to activity that inhibits these kingdoms of life. Many of these compounds have been shown to have bioactivity in mammalian systems as well, with epidemiological links to cancer chemoprevention in humans supported by in vitro, in vivo, and small clinical studies. Although other chemopreventive mechanisms have been identified, the primary mechanism believed to be responsible for the observed chemoprevention from GSHPs is the induction of antioxidant enzymes, such as NAD(P)H quinone reductase (NQO1), heme oxygenase 1 (HO-1), glutamate-cysteine ligase catalytic subunit (GCLC), and glutathione S transferases (GSTs), through the Keap1-Nrf2-ARE signaling pathway. Induction of this pathway is generally associated with aliphatic isothiocyanate GSHPs, although some indole-derived GSHPs have also been associated with induction of one or more of these enzymes.
Interdependencies between Biofuel, Fuel and Food Prices: The Case of the Brazilian Ethanol Market
Authors: Bentivoglio Deborah , Finco Adele , Bacchi Mirian
Published: June 2016

Brazil is currently the world’s largest sugar producer and exporter, as well as the world’s largest producer and consumer of sugarcane ethanol as a transportation fuel. The growth of this market originates from a combination of government policies and technological change, in both the sugarcane ethanol processing sector and the manufacture of flex-fuel vehicles. In recent years however, ethanol production has been questioned due to its possible impact on food prices. The present paper aims to explore the impact of Brazilian ethanol prices on sugar and gasoline prices. The relationships between a times series of these prices are investigated using a Vector Error Correction Model (VECM), supported by Granger Causality tests. In addition, Impulse Response Functions (IRFs) and Forecast Error Variance Decompositions (FEVD) are computed in order to investigate the dynamic interrelationships within these series. Our results suggest that ethanol prices are affected by both food and fuel prices, but that there is no strong evidence that changes in ethanol prices have an impact on food prices.
Scheduling of Electricity Storage for Peak Shaving with Minimal Device Wear
Authors: Van der Klauw Thijs , Hurink Johann , Smit Gerard
Published: June 2016

In this work, we investigate scheduling problems for electrical energy storage systems and formulate an algorithm that finds an optimal solution with minimal charging cycles in the case of a single device. For the considered problems, the storage system is used to reduce the peaks of the production and consumption within (part of) the electricity distribution grid, while minimizing device wear. The presented mathematical model of the storage systems captures the general characteristic of electrical energy storage devices while omitting the details of the specific technology used to store the energy. In this way, the model can be applied to a wide range of settings. Within the model, the wear of the storage devices is modeled by either: (1) the total energy throughput; or (2) the number of switches between charging and discharging, the so-called charging cycles. For the first case, where the energy throughput determines the device wear, a linear programming formulation is given. For the case where charging cycles are considered, an NP-hardness proof is given for instances with multiple storage devices. Furthermore, several observations about the structure of the problem are given when considering a single device. Using these observations, we develop a polynomial time algorithm of low complexity that determines an optimal solution. Furthermore, the solutions produced by this algorithm also minimize the throughput, next to the charging cycles, of the device. Due to the low complexity, the algorithm can be applied in various decentralized smart grid applications within future electricity distribution grids.
Assessment of Retrofitting Measures for a Large Historic Research Facility Using a Building Energy Simulation Model
Authors: Chae Young , Lee Young , Longinott David
Published: June 2016

A calibrated building simulation model was developed to assess the energy performance of a large historic research building. The complexity of space functions and operational conditions with limited availability of energy meters makes it hard to understand the end-used energy consumption in detail and to identify appropriate retrofitting options for reducing energy consumption and greenhouse gas (GHG) emissions. An energy simulation model was developed to study the energy usage patterns not only at a building level, but also of the internal thermal zones, and system operations. The model was validated using site measurements of energy usage and a detailed audit of the internal load conditions, system operation, and space programs to minimize the discrepancy between the documented status and actual operational conditions. Based on the results of the calibrated model and end-used energy consumption, the study proposed potential energy conservation measures (ECMs) for the building envelope, HVAC system operational methods, and system replacement. It also evaluated each ECM from the perspective of both energy and utility cost saving potentials to help retrofitting plan decision making. The study shows that the energy consumption of the building was highly dominated by the thermal requirements of laboratory spaces. Among other ECMs the demand management option of overriding the setpoint temperature is the most cost effective measure.
Streamer Propagation and Breakdown in a Very Small Point-Insulating Plate Gap in Mineral Oil and Ester Liquids at Positive Lightning Impulse Voltage
Authors: Rozga Pawel
Published: June 2016

This article presents the results of comparative studies on streamer propagation and breakdown in a point-insulating plate electrode system in mineral oil and two ester liquids. The studies were performed for a 10-mm gap and a positive standard lightning impulse. The work was focused on the comparison of light waveforms registered using the photomultiplier technique. The results indicated that both esters demonstrate a lower resistance against the appearance of fast energetic streamers than mineral oil. The reason for such a conclusion is that the number of lightning impulses supplied to the electrode system for which the above-mentioned fast streamers appeared at a given voltage level was always higher in the case of ester liquids than mineral oil. In terms of breakdown, the esters tested were assessed as more susceptible to the appearance of breakdown in the investigated electrode system. The number of breakdowns recorded in the case of esters was always greater than the corresponding number of breakdowns in mineral oil. This may be supposed on the basis of the obtained results that imply that, in both synthetic and natural ester, the formed breakdown channel, which bridged the gap through the surface of pressboard plate, is characterized by higher energy than in the case of mineral oil.