bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Education for Children with 22q11.2 Deletion Syndrome: A Qualitative Study of Mothers Perspectives
Authors: Roche Laura , Flynn Traci , Campbell Linda
Published: February 2024

22q11.2 deletion syndrome (22q11.2DS) is a complex and widely variable genetic syndrome involving multisystem physical health problems, significant cognitive and psychosocial challenges, all of which may impact upon learning and academic achievement. In the current study, we explored mothers’ perceptions of their child’s learning within early and primary educational contexts. We conducted 3 online focus groups and 1 online semi-structured interview with a total of 9 mothers of children diagnosed with 22q11.2DS. Mothers were included if their child had a genetic diagnosis of 22q11.2DS and was aged from 3 to 12 years old. The mothers were asked a series of open-ended questions to explore the educational experiences of their child. We adopted an inductive approach to our data analysis and conducted a reflexive thematic analysis resulting in the emergence of 4 major themes (1.) The impact of 22q11.2DS on a child’s learning; (2.) The impact of adaptive behaviour skills on their child’s learning; (3.) The level of support available within the educational setting and; (4.) Mothers’ perceptions about their child’s learning. From these themes, the following 12 sub themes were identified: absences affecting learning; the development of specific learning behaviours; the impact of a 22q11.2 DS diagnosis on their child’s self-perception; toileting, motor issues; communication; sleep; school and teacher support and the presence (or absence) of therapists. Finally, the mothers’ confidence about their child’s learning; mothers’ concerns and comparisons of their child; and mothers’ apprehension about their child’s future were all identified as sub-themes. Children with 22q11.2DS require increased and specific psychosocial support to allow them greater opportunities to fully participate in their learning environments. Mothers perceived the level of support their child received was greater during pre-school compared to that received at primary school. It was clear that a greater understanding of the needs of children with 22q11.2DS, by educators, was needed. Implications for tailored support for school-based learning and educational transitions for young children with 22q11.2DS are discussed.
The Jacobs Syndrome: Clinical Case
Authors: Tkachuk Elena A. , Kurenkova Galina
Published: February 2024

This work describes a clinical case of a violation of sex formation in a newborn child with Y-chromosome dysomy. The diagnostic challenges related to Y-chromosome variability and associated anomalies in sex development are being considered. The work presents clinical and laboratory data for Y-chromosome dysomy. It is noted that the challenge in diagnosing disorders of sex development is associated with the polymorphic clinical manifestations of this syndrome. It is noted that the presence of Y-chromosome dysomy is one of the most common chromosomal abnormalities, ranking third after Down syndrome and Klinefelter syndrome. It is often found that this pathology results in anomalies in genital development. A Y-chromosome polysomy is associated with variable phenotypic manifestations in gonadal development disorders.
Covid 19’s Social Quarantine-Moderated Self-Reported Mental Health and Substance Use Among US Adults
Authors: Rubino Shelby , Bufford Rodger K.
Published: March 2024

In 2019 the novel coronavirus spread quickly throughout the world. It was easily transmitted, resulting in a sudden increase in infection and death rates that overwhelmed hospitals. This sudden pandemic resulted in government and health officials mandating physical and social quarantines to decrease the spread of COVID-19. All these unexpected factors induced traumatic stress across the world. The impact of this trauma is seen to date, as many studies reported adverse mental health effects in an array of populations and researchers speculate these effects will continue long after COVID-19. The role of social quarantine as a moderating factor to these adverse mental health symptoms was assessed in a Qualtrics sample of 596 US adults. Participants completed a demographic survey, Adverse Childhood Experiences (ACEs) Questionnaire, COVID-19 Pandemic Mental Health Questionnaire, Patient Health Questionnaire-9, Generalized Anxiety Disorder Scale-7, International Trauma Questionnaire, Brief Resiliency Scale, and the Tobacco, Alcohol, Prescription Medication and Other Substances Tool. Hierarchical regressions with demographic and risk factors as predictors assessed the role of social quarantine as a moderator in predicting mental health symptoms. ACEs and risk factors were stronger predictors of mental health symptoms, but social quarantine added significant incremental variance in self-reported anxiety, depression, PTSD, complex PTSD, and substance use; β ranged for 0.24 to 0.30. Quarantine had a significant adverse impact on mental health symptoms among these adults. Fostering resilience and distress tolerance is a proposed clinical intervention.
CREATIVE ECONOMY IMPROVEMENT WITH ENTREPRENEURSHIP FOR THE PEOPLE OF SEMARANG CITY
Authors: Lasmiatun KMT
Published: February 2024

In facing business competition, the empowerment of human resources needs to be optimized so that people can be competitive, independent and able to compete with other products on the market in the era of the industrial revolution 4.0. The era of revolution 4.0 is a challenge in itself for MSMEs so that efforts are made to overcome these problems, namely socialization of Entrepreneurship and product innovation, socialization of Digital Marketing, socialization of Digital Payment, and investment counseling. The debriefing process requires the role of Community Service Program so that the goals can be created, namely the welfare of the community and educating businessman in business development in the future. This is expected that businessman will be able to create product improvement steps, and several aspects that need to be considered in running a business so that businessman in the Mangunharjo RW 03 will be more independent and innovative in facing business competition in the era of the industrial revolution 4.0.
FOSTERING A PROSPEROUS FAMILY, HEALTHY, AND FREE OF STUNTING IN CENTRAL JAVA: EMPIRICAL STUDY IN TINGKIR SALATIGA
Authors: Lasmiatun KMT , Muslikhatun Siti
Published: February 2024

Stunting is a condition when a toddler has a minimum height or body length compared to their age. Factors that influence the occurrence of stunting in children under five in rural and urban areas are mother's education, family income, mother's knowledge of nutrition, exclusive breastfeeding, age at which MP-ASI is given, zinc and iron adequacy levels, history of infectious diseases and genetic factors (Kemenkes, 2023). Activity objectives The output targets of this community service activity are increasing awareness of stunting prevention through improving parenting, understanding the role of housewives, increasing knowledge about financial literacy in the family, and understanding the nutritional needs of pregnant women. Community service activities were carried out in the Tingkir Tengah Village meeting room with the target of involving 45 representatives from 10 RW. Participants consisted of Posyandu cadres, PKK cadres, dashat cadres, and Pregnant Women. Community service activities went well according to plan. The event was attended by more than 80% of invited participants consisting of posyandu cadres, dashat cadres, and pregnant women. This activity is expected to increase knowledge so that reduction and prevention of stunting can be implemented.
Acciones para el mejoramiento genético de la raza bovina criolla Sanmartinero
Authors: Rosero Alpala Jaime Aníbal , Burgos Paz William Orlando , Flórez Díaz Hernando , Bejarano Garavito Diego Hernán , Onofre Rodríguez Héctor Guillermo
Published: February 2024

A través de las propuestas del plan de fomento, muchos ganaderos han reconocido las bondades y los atributos de las razas bovinas criollas para la producción de carne y leche en el país. Una de estas razas es el Sanmartinero (sm), la cual se destaca por su fertilidad y adaptación a las condiciones del piedemonte y altillanura orinoquense. Dichos atributos han servido de pauta en los procesos de monitoreo de parámetros reproductivos y adaptativos en los cuales se enfocan las estrategias para el mejoramiento genético de la raza sm. En la actualidad, productores del piedemonte y la altillanura y el núcleo de mejoramiento genético en el Centro de Investigación Carimagua conforman una red para uso y monitoreo de la raza, dando lugar a la consolidación de acciones como el desarrollo de la cuarta edición de las pruebas de desempeño en pastoreo de toretes Sanmartinero en el Centro de Investigación La Libertad.
Caracterización del transporte de ovinos y manejos pre-sacrificio en una planta de beneficio del Caribe húmedo colombiano
Authors: Aguayo Ulloa Lorena , Salcedo Erica , Medina Diego , Mejía Jorge , Suárez Emiro
Published: March 2024

En Colombia, la cadena ovino-caprina está recién constituida, por lo que estudios de diagnóstico y actividades de eslabonamiento son cada vez más necesarios para fortalecer el sector. Investigaciones que evalúen el manejo y bienestar de los ovinos desde la nca hasta la planta de benecio (PB), son prácticamente inexistentes en la región Caribe colombiana. El objetivo de este estudio fue caracterizar el transporte y el manejo pre-sacricio de ovinos en una PB de la región. URI
Manejo de mosca del botón ﬂoral (Dasiops inedulis) en cultivos de maracuyá (Passiﬂora edulis f. ﬂavicarpa) de La Plata, Huila
Authors: Sierra Baquero Paola Vanessa , Varón Devia Edgar Herney , Ballestas Alvarez Karen Lorena
Published: March 2024

En Colombia las pasifloras son de gran importancia debido a que su exportación presenta una tendencia al alza y son muy apetecidas en el comercio internacional. Una de las especies de mayor importancia es el maracuyá (Passiflora edulis f. flavicarpa) (SIOC, 2018).
Six-Month Outcomes of a Theory- and Technology-Enhanced Physical Activity Intervention for Latina Women (Pasos Hacia La Salud II): Randomized Controlled Trial
Authors: Connell Bohlen Lauren , Dunsiger Shira I , von Ash Tayla , Larsen Britta A , Pekmezi Dori , Marquez Becky , Benitez Tanya J , Mendoza-Vasconez Andrea , Hartman Sheri J , Williams David M , Marcus Bess H
Published: March 2024

Background

More than half (55%) of Latina women do not meet aerobic physical activity (PA) guidelines, and frequently cite time, childcare, and transportation as barriers to PA. In addition to linguistic adaptations for this population, successful PA interventions for Latina women addressed these barriers through remote intervention delivery approaches (eg, mail, phone, or web delivery).

Objective

We aimed to evaluate 6-month outcomes of a randomized trial comparing a Spanish-language, individually tailored, web-delivered PA intervention (original) to an enhanced version with text messages and additional features (enhanced). Further, we evaluated if increases in PA at 6 months were moderated by baseline activity status.

Methods

In total, 195 Latina women aged 18-65 years participated in a trial comparing the efficacy of the enhanced versus original interventions at initiating PA behavior change. We examined minutes per week of accelerometer-measured PA in the enhanced versus original arms, and the proportion of each arm meeting aerobic PA guidelines (150 min/wk at 6 mo). For moderator analyses, participants were classified as inactive (0 min/wk) or low active (1-90 min/wk) at baseline, measured via the 7 Day Physical Activity Recall interview.

Results

PA increased from 19.7 (SD 47.9) minutes per week at baseline to 46.9 (SD 66.2) minutes per week at 6 months in the enhanced arm versus 20.6 (SD 42.7) minutes per week to 42.9 (SD 78.2) minutes per week in the original arm (P=.78). Overall, 30% (31/103) of the enhanced group met aerobic PA guidelines at 6 months, compared to 21% (19/92) of the original group (odds ratio [OR] 1.75, 95% CI 0.87-3.55). Baseline PA (inactive vs low active) moderated treatment effects on PA. For inactive participants, there were no group differences at 6 months (b=7.1; SE 22.8; P=.75), while low-active participants increased more in enhanced than original (b=72.5; SE 27.9; P=.01). For low-active participants, 45% (46/103) of the enhanced group met PA guidelines at 6 months, versus 20% (18/92) of the original arm (OR 3.29, 95% CI 1.05-11.31). For inactive participants, there were no group differences (25/103, 24% vs n=19/92, 21% for enhanced vs original, respectively; OR 1.28, 95% CI 0.54-3.06).

Conclusions

Intervention effects were conditional on baseline PA. For low-active Latina women, the enhanced intervention was more effective at increasing PA. Additional tailored intervention enhancements may be necessary to increase PA for inactive Latina women.

Trial Registration

ClinicalTrials.gov NCT03491592; https://www.clinicaltrials.gov/study/NCT03491592

International Registered Report Identifier (IRRID)

RR2-10.1186/s13063-022-06575-4
Moderating Effect of Depression on Glycemic Control in an eHealth Intervention Among Black Youth With Type 1 Diabetes: Findings From a Multicenter Randomized Controlled Trial
Authors: Ellis Deborah , Carcone April Idalski , Templin Thomas , Evans Meredyth , Weissberg-Benchell Jill , Buggs-Saxton Colleen , Boucher-Berry Claudia , Miller Jennifer L , Drossos Tina , Dekelbab M Bassem
Published: February 2024

Background

Black adolescents with type 1 diabetes (T1D) are at increased risk for suboptimal diabetes health outcomes; however, evidence-based interventions for this population are lacking. Depression affects a high percentage of youth with T1D and increases the likelihood of health problems associated with diabetes.

Objective

Our aim was to test whether baseline levels of depression moderate the effects of a brief eHealth parenting intervention delivered to caregivers of young Black adolescents with T1D on youths’ glycemic control.

Methods

We conducted a multicenter randomized controlled trial at 7 pediatric diabetes clinics located in 2 large US cities. Participants (N=149) were allocated to either the intervention group or a standard medical care control group. Up to 3 intervention sessions were delivered on a tablet computer during diabetes clinic visits over a 12-month period.

Results

In a linear mixed effects regression model, planned contrasts did not show significant reductions in hemoglobin A1c (HbA1c) for intervention adolescents compared to controls. However, adolescents with higher baseline levels of depressive symptoms who received the intervention had significantly greater improvements in HbA1c levels at 6-month follow-up (0.94%; P=.01) and 18-month follow-up (1.42%; P=.002) than those with lower levels of depression. Within the intervention group, adolescents had a statistically significant reduction in HbA1c levels from baseline at 6-month and 18-month follow-up.

Conclusions

A brief, culturally tailored eHealth parenting intervention improved health outcomes among Black adolescents with T1D and depressive symptoms.

Trial Registration

ClinicalTrials.gov NCT03168867; https://clinicaltrials.gov/study/NCT03168867
Identifying Unmet Needs in Major Depressive Disorder Using a Computer-Assisted Alternative to Conventional Thematic Analysis: Qualitative Interview Study With Psychiatrists (Preprint)
Authors: Worthington Michelle A , Christie Richard H , Masino Aaron J , Kark Sarah M
Published: March 2024

BACKGROUND

The development of digital health tools that are clinically relevant requires a deep understanding of the unmet needs of stakeholders, such as clinicians and patients. One way to reveal unforeseen stakeholder needs is through qualitative research, including stakeholder interviews. However, conventional qualitative data analytical approaches are time-consuming and resource-intensive, rendering them untenable in many industry settings where digital tools are conceived of and developed. Thus, a more time-efficient process for identifying clinically relevant target needs for digital tool development is needed.

OBJECTIVE

The objective of this study was to address the need for an accessible, simple, and time-efficient alternative to conventional thematic analysis of qualitative research data through text analysis of semistructured interview transcripts. In addition, we sought to identify important themes across expert psychiatrist advisor interview transcripts to efficiently reveal areas for the development of digital tools that target unmet clinical needs.

METHODS

We conducted 10 (1-hour-long) semistructured interviews with US-based psychiatrists treating major depressive disorder. The interviews were conducted using an interview guide that comprised open-ended questions predesigned to (1) understand the clinicians’ experience of the care management process and (2) understand the clinicians’ perceptions of the patients’ experience of the care management process. We then implemented a hybrid analytical approach that combines computer-assisted text analyses with deductive analyses as an alternative to conventional qualitative thematic analysis to identify word combination frequencies, content categories, and broad themes characterizing unmet needs in the care management process.

RESULTS

Using this hybrid computer-assisted analytical approach, we were able to identify several key areas that are of interest to clinicians in the context of major depressive disorder and would be appropriate targets for digital tool development.

CONCLUSIONS

A hybrid approach to qualitative research combining computer-assisted techniques with deductive techniques provides a time-efficient approach to identifying unmet needs, targets, and relevant themes to inform digital tool development. This can increase the likelihood that useful and practical tools are built and implemented to ultimately improve health outcomes for patients.
Different applications of Artificial Intelligence in liver cancer: a scoping review – part II, from treatment planning and efficacy assessment to prognosis prediction and follow-up. (Preprint)
Authors: Chierici Andrea , Lareyre Fabien , Salucki Benjamin , Iannelli Antonio , Guzzi Lisa , Goffart Sebastien , Delingette Hervé , Raffort Juliette
Published: March 2024

BACKGROUND

Artificial Intelligence (AI) plays a pivotal role in early detection and personalized treatment of liver cancer. The integration of AI in screening and diagnosis enhances detection accuracy and aids in formulating effective treatment strategies, but it can be an effective tool to guide liver cancer management in all the steps from treatment deliverance to follow-up.

OBJECTIVE

This is the second part of a scoping review on implementation of AI and liver cancer, focusing on treatment planning and efficacy assessment, prognosis prediction, and follow-up.

METHODS

A systematic review was performed on PubMed, Embase, Scopus, and Web of Science databases including research published between January the 1st 2020 and September the 30th 2023.

RESULTS

AI-driven tools offer predictive analytics for prognosis, treatment planning, and efficacy assessment, aiming to optimize patient outcomes. In liver cancer management, AI assists in treatment planning, such as liver resection and radioembolization, by improving preoperative mapping and predicting therapeutic response. Additionally, AI models predict chemotherapy efficacy based on patient-specific factors, facilitating tailored treatment approaches. Moreover, leveraging AI models, integrating clinical, biochemical, radiological, and histological data, enables accurate prognostication at diagnosis and post-treatment. Key factors such as microvascular invasion, tumor capsule integrity, and grade significantly influence liver cancer prognosis, often assessed using AI-driven predictive models. Imaging modalities, coupled with AI algorithms, exhibit high accuracy in predicting microvascular invasion, aiding treatment planning and prognosis assessment.
Following treatment, AI plays a crucial role in prognosis assessment. For patients undergoing liver resection, machine learning models predict disease-free survival, aiding decisions regarding adjuvant chemotherapy. Similarly, models for thermoablation and liver transplantation provide insights into recurrence risk, guiding post-treatment follow-up. In patients receiving systemic treatment like immunotherapy, AI-based models predict cancer-related mortality and overall survival, facilitating treatment response assessment and patient stratification.

CONCLUSIONS

AI finds wide application in the management of liver cancer treatment and follow-up.
Despite promising advancements, challenges remain, including the need for external validation and adaptation to diverse patient populations. Further research is essential to realize the full potential of AI in liver cancer management and translate it into clinical impact.

CLINICALTRIAL
Effect of an AI agent trained on a large language model (LLM) as an intervention for depression and anxiety symptoms in young adults: a 28-day randomized controlled trial (Preprint)
Authors: Zhao Yuqing , Qian Wei , Chen Yaru , Wu Donghong , Luo Yujia , Wu Kankan , Liu Zhengkui
Published: March 2024

BACKGROUND

Internet- and mobile-based psychological interventions (IMIs) have the advantages of being more accessible, less costly in terms of time and money, and more user friendly than traditional psychological interventions. Young adults face emotional problems in their daily lives that cannot be ignored, and youth are becoming the mainstay of the mobile internet. Large language modeling techniques are rapidly evolving and show great potential for understanding and generating natural language, enabling more effective interaction with human dialog than traditional techniques, and large language model (LLM)-based AI conversational agents may play an important role in intervening in young adults’ negative emotions.

OBJECTIVE

The aim of this study is to investigate whether an AI agent trained on a LLM can intervene in depression and anxiety in young people with negative emotions and to determine the effectiveness of such intervention.

METHODS

This study is a 28-day randomized controlled trial (RCT). Residents were randomly assigned to an intervention group or a waiting group according to the order in which they were successfully contacted by the staff, and each user was asked to engage in a total of 28 days of dialog intervention with the Douyin companion bot and complete three psychological questionnaires (on Days 1, 14, and 28); however, the intervention group began to receive the dialog intervention after completing the first questionnaire, and the waiting group began to receive the dialog intervention after completing the third questionnaire. During the first four weeks, the waiting group was treated as a blank control. The two groups of subjects completed the three questionnaires at exactly the same point in time. Each user's depression, anxiety, and positive and negative emotions were measured using the Patient Health Questionnaire (PHQ-9), the Generalized Anxiety Disorder Scale (GAD-7) and the Positive and Negative Affect Schedule (PANAS), respectively.

RESULTS

Data from 657 users who completed pre-, mid- and posttreatment measures were included in the analyses. The prevalence of mild depression and anxiety among participants at baseline was 44.3% and 23.4%, respectively. The results showed a significant reduction in negative moods in the intervention group after four weeks of the dialog intervention, which was not found when the dialog intervention was conducted for a fortnight. Repeated-measures ANOVA showed that the dialog intervention significantly reduced depression in the intervention group at two weeks and significantly reduced both depression and anxiety in the intervention group at four weeks.

CONCLUSIONS

Overall, LLM-based AI conversational agents can effectively alleviate the mild anxiety and depressive symptoms of young adults with negative emotions through dialog interventions.
German Version of the Telehealth Usability Questionnaire and Derived Short Questionnaires for Usability and Perceived Usefulness in Health Care Assessment in Telehealth and Digital Therapeutics: Instrument Validation Study (Preprint)
Authors: Zimmermann Jannik , Morf Harriet , Scharf Florian , Knitza Johannes , Moeller Heidi , Muehlensiepen Felix , Nathrath Michaela , Orlemann Till , Voelker Thomas , Deckers Merlin
Published: March 2024

BACKGROUND

The exponential growth of telehealth is revolutionizing health care delivery, but its evaluation has not matched the pace of its uptake. Various forms of assessment, from single-item to more extensive questionnaires, have been used to assess telehealth and digital therapeutics and their usability. The most frequently used questionnaire is the “Telehealth Usability Questionnaire” (TUQ). The use of the TUQ is limited by its restricted availability in languages other than English and its feasibility.

OBJECTIVE

The aims of this study were to create a translated German TUQ version and to derive a short questionnaire for patients—“Telehealth Usability and Perceived Usefulness Short Questionnaire for patients” (TUUSQ).

METHODS

As a first step, the original 21-item TUQ was forward and back-translated twice. In the second step, 13 TUQ items were selected for their suitability for the general evaluation of telehealth on the basis of expert opinion. These 13 items were surveyed between July 2022 and September 2023 in 4 studies with patients and family members of palliative care, as well as patients with chronic autoimmune diseases, evaluating 13 health care apps, including digital therapeutics and a telehealth system (n1=128, n2=220, n3=30, and n4=12). Psychometric exploratory factor analysis was conducted.

RESULTS

The analysis revealed that a parsimonious factor structure with 2 factors (“perceived usefulness in health care” and “usability”) is sufficient to describe the patient’s perception. Consequently, the questionnaire could be shortened to 6 items without compromising its informativeness.

CONCLUSIONS

We provide a linguistically precise German version of the TUQ for assessing the usability and perceived usefulness of telehealth. Beyond that, we supply a highly feasible shortened version that is versatile for general use in telehealth, mobile health, and digital therapeutics, which distinguishes between the 2 factors “perceived usefulness in health care” and “usability” in patients.

CLINICALTRIAL

German Clinical Trials Register DRKS00030546; https://drks.de/search/de/trial/DRKS00030546
Clinical and Biochemical Outcomes in Transgender Individuals Undergoing Hormone Therapy: Protocol for a Systematic Review (Preprint)
Authors: Sattora Emily , Teelin Karen , Prendergast Christopher , Smith Abigail , Evans James , Imdad Aamer
Published: March 2024

BACKGROUND

Monitoring of various clinical outcomes and parameters, such as lipid levels, is recommended in transgender individuals undergoing hormone therapies. However, comprehensive data to inform these recommendations is scarce.

OBJECTIVE

This study aims to conduct a systematic review and meta-analysis to synthesize evidence from existing literature on the effect of exogenous hormone therapy on clinical and biochemical outcomes for transgender adolescents and adults.

METHODS

We will search multiple electronic databases and will include prospective and retrospective observational studies with and without a control group. The study population will include transgender individuals undergoing hormone therapy with testosterone or estrogen. Comparisons will include age-matched, cisgender individuals and changes from baseline. Primary outcomes include changes in or the development of abnormal lipid parameters. Secondary outcomes include BMI, weight, height, and blood pressure for age, serum testosterone or estrogen levels, and development of disease including hypertension, diabetes, fatty liver disease, obesity, adverse cardiac events, as well as all-cause mortality. The meta-analysis will pool the studies where applicable, and meta-regressions will be conducted to evaluate effect modifiers. The GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach will be used to evaluate the overall certainty of evidence.

RESULTS

We will summarize the selection of the eligible studies using a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart. The results will be presented in a table summarizing the evidence. Data collection is ongoing, and the paper is expected to be published in Spring 2025.

CONCLUSIONS

This systematic review will summarize and evaluate the evidence of the clinical and biochemical outcomes associated with hormone therapies for transgender individuals.

CLINICALTRIAL

PROSPERO CRD42024483138; https://tinyurl.com/yc4sfvnb

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/57931
Effectiveness and Acceptability of Targeted Text Message Reminders in Colorectal Cancer Screening: Randomized Controlled Trial (M-TICS Study) (Preprint)
Authors: Vives Nuria , Travier Noemie , Farre Albert , Binefa Gemma , Vidal Carmen , Pérez Lacasta Maria Jose , Ibáñez-Sanz Gemma , Niño de Guzmán Ena Pery , Panera Jon Aritz , Garcia Montse ,   M-TICS Research Group
Published: March 2024

BACKGROUND

Mobile phone–based SMS text message reminders have the potential to improve colorectal cancer screening participation rates.

OBJECTIVE

This study assessed the effectiveness and acceptability of adding targeted SMS text message reminders to the standard procedure for those who picked up but did not return their screening kit at the pharmacy within 14 days in a colorectal cancer screening program in Catalonia, Spain.

METHODS

We performed a randomized control trial among individuals who picked up a fecal immunochemical test (FIT) kit for colorectal cancer screening at the pharmacy but did not return it within 14 days. The intervention group (n=4563) received an SMS text message reminder on the 14th day of kit pick up and the control group (n=4806) received no reminder. A 30-day reminder letter was sent to both groups if necessary. The main primary outcome was the FIT completion rate within 30, 60, and 126 days from FIT kit pick up (intention-to-treat analysis). A telephone survey assessed the acceptability and appropriateness of the intervention. The cost-effectiveness of adding an SMS text message reminder to FIT completion was also performed.

RESULTS

The intervention group had higher FIT completion rates than the control group at 30 (64.2% vs 53.7%; P<.001), 60 (78.6% vs 72.0%; P<.001), and 126 (82.6% vs 77.7%; P<.001) days. Participation rates were higher in the intervention arm independent of sex, age, socioeconomic level, and previous screening behavior. A total of 339 (89.2%) interviewees considered it important and useful to receive SMS text message reminders for FIT completion and 355 (93.4%) preferred SMS text messages to postal letters. We observed a reduction of US $2.4 per participant gained in the intervention arm for invitation costs compared to the control arm.

CONCLUSIONS

Adding an SMS text message reminder to the standard procedure significantly increased FIT kit return rates and was a cost-effective strategy. SMS text messages also proved to be an acceptable and appropriate communication channel for cancer screening programs.

CLINICALTRIAL

ClinicalTrials.gov NCT04343950; https://www.clinicaltrials.gov/study/NCT04343950

INTERNATIONAL REGISTERED REPORT

RR2-10.1371/journal.pone.0245806
Combined Serologic and Genetic Risk Score and Prognostication of Phospholipase A2 receptor-Associated Membranous Nephropathy
Authors: Hu Xiaofan , Xu Jing , Wang Wei , Liu Lili , Jing Yuanmeng , Gao Chenni , Yu Xialian , Li Yi , Lin Li , Tong Jun , Weng Qinjie , Pan Xiaoxia , Zhang Wen , Ren Hong , Li Guisen , Kiryluk Krzysztof , Chen Nan , Xie Jingyuan
Published: March 2024

Introduction

The aim of this study was to test whether a combined risk score on the basis of genetic risk and serology can improve the prediction of kidney failure in phospholipase A2 receptor (PLA2R)-associated primary membranous nephropathy.

Methods

We performed a retrospective analysis of 519 biopsy-proven PLA2R-associated primary membranous nephropathy patients with baseline eGFR ≥25 ml/min per 1.73 m2. The combined risk score was calculated by combining the genetic risk score with PLA2R ELISA antibody titers. The primary end point was kidney disease progression defined as a 50% reduction in eGFR or kidney failure. Cox proportional hazard regression analysis and C-statistics were applied to compare the performance of PLA2R antibody, genetic risk score, and combined risk score, as compared with clinical factors alone, in predicting primary outcomes.

Results

The median age was 56 years (range, 15–82 years); the male-to-female ratio was 1:0.6, the median eGFR at biopsy was 99 ml/min per 1.73 m2 (range: 26–167 ml/min per 1.73 m2), and the median proteinuria was 5.3 g/24 hours (range: 1.5–25.8 g/24 hours). During a median follow-up of 67 (5–200) months, 66 (13%) had kidney disease progression. In Cox proportional hazard regression models, PLA2R antibody titers, genetic risk score, and combined risk score were all individually associated with kidney disease progression with and without adjustments for age, sex, proteinuria, eGFR, and tubulointerstitial lesions. The best-performing clinical model to predict kidney disease progression included age, eGFR, proteinuria, serum albumin, diabetes, and tubulointerstitial lesions (C-statistic 0.76 [0.69–0.82], adjusted R2 0.51). Although the addition of PLA2R antibody titer improved the performance of this model (C-statistic: 0.78 [0.72–0.84], adjusted R2 0.61), replacing PLA2R antibody with the combined risk score improved the model further (C-statistic: 0.82 [0.77–0.87], adjusted R2 0.69, difference of C-statistics with clinical model=0.06 [0.03–0.10], P < 0.001; difference of C-statistics with clinical–serologic model=0.04 [0.01–0.06], P < 0.001).

Conclusions

In patients with PLA2R-associated membranous nephropathy, the combined risk score incorporating inherited risk alleles and PLA2R antibody enhanced the prediction of kidney disease progression compared with PLA2R serology and clinical factors alone.
Discussion on the Evaluation Method of University Physics Experiment Assessment Based on “4C” Ability Cultivation
Authors: Wang Nan , Sun Yu , Song LianPeng , Liu JinSong
Published: March 2024

Education evaluation concerns the direction of education development, what use evaluation command bar, what kind of school orientation. To develop students abilities in Creativity and Innovation, Critical-thinking and Problem-solving, Communication, Collaboration. From the general idea of “Improve the evaluation of results, strengthen the process evaluation, explore value-added evaluation and make full use of information technology”. Study of University Physical Experimental Assessment Methodology, divided the assessment evaluation into formative and final examination two parts, and explored formative assessment methods and final evaluation methods. The formative evaluation methods, including “pre-class preparation, class performance, experimental results” are proposed for most of the three, and the final evaluation of many forms of the examination, such as “written exam, work, virtual simulation, innovative physical work display, group reporting and replies”.
La migración de personas haitianas a Ciudad Acuña, Coahuila, México
Authors: Núñez Medina Gerardo , Uribe Salas Felipe Javier
Published: March 2024

En este trabajo se analizan los determinantes que llevaron a migrantes de origen haitiano, refugiados en el albergue El Fandango de Ciudad Acuña, Coahuila, a tomar la decisión de viajar a través de México, considerando un conjunto de factores demográficos y socioeconómicos entre los que destaca su lugar de residencia anterior en países como Chile o Brasil. Mediante la aplicación de un modelo de regresión logística, se identificaron una serie de determinantes de la migración de haitianos, y los resultados indican que quienes más cruzaron por México eran hombres con familiares en Estados Unidos, provenientes de Brasil y que contaban con estudios de bachillerato o educación superior.
Los entramados del desarrollo en la selva Lacandona: una lectura sobre la configuración de las políticas de desarrollo y gobernanza global
Authors: Mendoza Solís Yeri Paulina
Published: March 2024

En el artículo se analizan los procesos de transformación sociopolítica dela selva Lacandona a partir de tres principales tramas que han hecho del territorio una región para el desarrollo: la trama del extractivismo colonial, la trama del desarrollo rural y la trama del desarrollo sostenible y la conservación ambiental. Se plantea que en los actuales entramados del desarrollo confluyen políticas, actores y proyectos de gobernanza, en el marco de las políticas de desarrollo productivo basadas en la agricultura comercial y las iniciativas de reconfiguración del territorio desde la sostenibilidad. Con base en esta lectura se visualizan las tensiones y contradicciones de las políticas del desarrollo que han hecho de la selva Lacandona un mundo-regional donde convergen principios, ideas e iniciativas del desarrollo heterogéneas, las cuales coexisten en el territorio y dotan de contenido a la región.
Territorio sonoro o los sonidos de la ciudad
Authors: De Gortari Ludlow Jimena
Published: March 2024

Los sonidos de la ciudad son cambiantes, nos movemos por ella sin prestar atención y su análisis –las cartografías– reflejan sólo una parte. Es por ello que es necesario considerar otros aspectos: como el diseño y las formas de la ciudad, pero sobre todo la experiencia que narran quienes la escuchan y la viven.
sonido como herramienta en la investigación de arquitectura forense
Authors: Morfín Ramírez Mely Adriana
Published: March 2024

El sonido en el campo de la arquitectura forense puede operar como herramienta de análisis y como herramienta de comunicación. En este ensayo se exploran estas posibilidades en algunas de las investigaciones realizadas por Forensic Architecture.
Potato Leaf Disease Classification using Deep Learning Technique CNN
Authors: S Reshni
Published: March 2024

Abstract: In this work, we suggest a unique method that makes use of convolutional neural networks (CNN) to identify potato leaf disease. Our approach makes use of deep learning to precisely identify and categorise a range of illnesses that impact potato leaves. We achieve great levels of accuracy and robustness in disease identification by training the CNN model on a large dataset of healthy and diseased potato leaves. Farmers and agronomists may identify and control illnesses more quickly and automatically with the help of this suggested technique, which will increase crop output and production. Our technique has shown encouraging results through thorough experimentation and validation, indicating its potential for real-world use in agricultural contexts.
Minimizing the Formation of Thermal Residual Stresses of the Elastic Zone in Functionally Graded Materials
Authors: Khouja Farag A.
Published: March 2024

Abstract: Functionally graded materials (FGM’s) are advanced composites consisting of two or more materials whose composition and structure changes gradually over the volume, leading to gradual change in its property. Typically one component is a ceramic, while the other is metal or metal alloy. In common embodiments, the composition can change gradually from all ceramic on one side to all metal on the other side, the ceramic contributing high resistance to temperature with the metal contributing high ductility. It’s a way to incorporate favorable properties of two materials into different locations of a single structure. In ideal cases the composition changes gradually but for manufacturing reasons, the changes occurs in homogeneous layers. The boundaries between the layers cause thermal residual stresses to arise, especially during material processing and in cases of cyclic loading. These thermal residual stresses are a result of differences in the thermal expansion coefficient of the varying compositions of materials. Thermal residual stresses may lead to cracking and ultimate failure of FGM’s. This study investigates the formation of thermal residual stresses for a Nickel-Alumina Ni-Al₂O₃ FGM. The Ni-Al₂O₃ system is chosen because it is one of the most common systems used in practice. This work explores the formation, impact and minimization of thermal residual stresses for a number of practical conditions that may arise during processing. All relevant properties are calculated using the rule of mixture equations. Abaqus, a non-linear FEA solver, is used for all the simulation work. In addition, the study highlights the need for examining elasto-plastic analysis to illuminate the process of crack development which is our future research goal.
Acoustic Emission, A Non-Destructive Technique - An Overview
Authors: Solanki Lalit Kumar , Munzni B. K. , Vidyarthi U S
Published: February 2024

Abstract: With increasing number of structures approaching their design life, it became very important for the designers and operators to develop innovative Structural Health Monitoring (SHM) techniques. Structural Health Monitoring (SHM) is the process of monitoring or assessing the condition of a structure in order to gather information on its current state by tracking variables like vibration, strain, stress and other physical phenomena, responses and conditions. It seeks to assist in nondestructive evaluations aimed to detect location and extent of damage, calculate the remaining life of an asset and predict upcoming accidents. Acoustic Emission technique is a passive monitoring approach based on the detection of elastic waves in structural components generated by damages, such as the initiation and propagation of cracks, the failure of steel wires, and the failure of bonds. Its primary goal is to detect, locate, and assess the intensity of damage in a non-invasive way, both when the structure is in-service and during load tests. Its application in SHM (Structural Health Monitoring) started much later compared to other fields, such as the aerospace industry. The interest has increased because elastic waves generated by damages propagate throughout the structure; therefore, it is possible to remotely detect damages in areas that are not easily accessible to visual inspections and direct measurements
Variables sociodemográficas y percepción de prejuicios de las personas con discapacidad
Authors: Sainz Palafox Miguel Angel , Vera Noriega José Ángel , Peña Ramos Martha Olivia , Tánori Quintana Jesús
Published: February 2024

Entre las barreras sociales que enfrentan las personas con discapacidad se encuentran los prejuicios, definidos como actitudes de aversión y hostilidad por la pertenencia a un grupo al que se le adjudican características indeseables. La percepción de prejuicios puede estar determinada por factores vinculados a variables sociodemográficas; sin embargo, pocos estudios se han enfocado en diferenciar las experiencias de las personas con discapacidad, en especial en el contexto mexicano. Se examinaron las opiniones de 5145 personas con discapacidad, a través de la Encuesta Nacional de Discriminación 2017, comparando la percepción de prejuicios de las personas con discapacidad a través de la edad, el género, el nivel socioeconómico, el tamaño de la localidad y el índice de desarrollo humano (IDH). El análisis factorial confirmatorio arroja una estructura con dos factores: prejuicios endogrupales y exogrupales. Los resultados indican que los adultos mayores, las personas que pertenecen a estratos sociodemográficos bajos y quienes habitan en localidades con un IDH bajo enfrentan mayores prejuicios en la escala total y en prejuicios endogrupales. Se discute el impacto del envejecimiento y la disponibilidad de recursos sociales en la percepción de prejuicios de las personas con discapacidad.
Investigation of Emotional Intelligence, Self-Efficacy, and Perceived Organizational Support as Enablers of Subjective Well Being
Authors: Sitorus Renalwin , Messayu Paramitha , Asrunputri Aisyah Pia , Anggiani Sarfilianty
Published: February 2024

With the everchanging business environment, organization must revisit the way their approach they employee. It is imperative to think ways to provide happiness for employees. The researchers chose to investigate emotional intelligence, self-efficacy, and perceived organizational support as enablers of subjective well-being using 263 samples of Indonesian workers and employs purposive sampling as the sampling technique. The result shows that: (1) Emotional intelligence has a positive and significant influence on subjective well-being; (2) self-efficacy shows a negative and insignificant influence on subjective well-being; (3) perceived organizational support has a positive correlation with insignificant influence on subjective well-being.
The Impact of Macroeconomic Fundamental Policies on The Composite Stock Price Index
Authors: Nadhilla Zhafa , Sriyono Sriyono
Published: February 2024

This study aims to test the purpose of this study, namely to determine the effect of Gross Domestic Product, Inflation, Interest Rates and Rupiah Exchange Rate on the Composite  Stock Price Index.This type of research uses  quantitative  methods  and using secondary data. The data used in this study are time series of Gross Domestic Product, Inflation, Interest Rates, Rupiah Exchange Rate and JCI during the  2011-2020 period. Sampling from this study used the saturated sample method from the monthly data of  each variable for 10 years, so that 120 samples were obtained.  This research uses multiple linear analysis techniques with the application of eviews 9. The results of  this study show that the Gross Domestic Product variable   has a positive and significant  influence on the JCI, the Inflation variable has a positive and significant influence on the JCI, the  Interest Rate  variable does not have  a significant influence on the JCI and the Rupiah Exchange Rate variable has a negative and significant influence on the JCI.
Vildagliptin Nephroprotective Effect in Rats Model with Cisplatin-Induced Nephrotoxicity
Authors: Watife Abeer T. , Bairam Ahsan F. , Al-Ghuraibawi Nibras H.
Published: February 2024

Objective: To evaluate the nephroprotective effect of vildagliptin against cisplatin-induced nephrotoxicity in rats.

Methods and Materials: Twenty-eight male rats have been divided into four groups: Control (received distal water), cisplatin treated group (received single dose of cisplatin (7mg/kg) intraperitoneally (IP) on day eight), vildagliptin plus cisplatin treated group (received vildagliptin 10mg/kg/day orally for 14 days, seven days before and seven days after the dose of cisplatin on day eight), and vildagliptin treated group (received the same dose and duration of vildagliptin mentioned previously). At the end, blood samples were collected to evaluate tumor necrotic factor-α (TNF-α), caspase-3, total antioxidant capacity (TAOC), urea, and creatinine. The serum levels of these biomarkers were expressed as mean ± standard error of mean. Additionally, kidneys were fixed in formalin for histopathological examination.

Result: Vildagliptin treatment significantly reduced the serum levels of TNF-α, caspase-3, urea, and creatinine as well as increased the TAOC level in rats treated with vildagliptin plus cisplatin when compared with cisplatin treated group. Histopathological examination further supported the nephroprotective effect of vildagliptin in rats with cisplatin induced nephrotoxicity. 

Conclusion: Vildagliptin improved kidney function and reduced cisplatin nephrotoxicity which may highlight the nephroprotective effect of this DPP-4 inhibitor against cisplatin-induced nephrotoxicity.