bluuebunny/crossref_metadata_2025 huggingface dataset:
IN VITRO EFFECTS OF POLYPHENOLS EXTRACTED FROM THE AROEIRA PLANT (SCHINUS TEREBINTHIFOLIUS RADDI) ON THE GROWTH OF PROSTATE CANCER CELLS (LNCaP, PC-3 AND DU145)
Authors: Queires Luis Carlos , Crépin Michel , Vacherot Francis , De la Taille Alex , Erlon Rodrigues Luiz
Published: April 2016

Despite the existence of various types of antineoplastic treatments of prostate cancer, most of them induce apoptosis in the tumor cells by means of synthetic or natural drugs. The aim of this work was to study the antiproliferative action of methanolic and aqueous extracts from the leaves of the aroeira plant (Schinus terebinthifolius) a plant from the Northeast from Brazil over isolated prostate cancer cell cultures. The extracts were tested in isolated cell lineages from non hormone dependent cancers (DU145 e PC-3), as well as in hormone-dependent ones (LNCaP). The cells were cultivated in a RPMI medium and were incubated at 37oC in a 5% CO2, humid environment. The activities of the extracts were evaluated within 3 and 6 days of cellular growth. The aqueous extract was more effective than the methanolic one in the inhibition of cell multiplication in all the lineages tested
ACUTE MYOCARDITIS IN THE MAGNETIC RESONANCE IMAGING ERA: PATIENT’S CHARACTERISTICS AND MID-TERM FOLLOW-UP.
Authors: Karam Carma , Alghamdi Ali , Mansencal Nicolas , Binsse Stephen , Lacombe Pascal , Dubourg Olivier
Published: April 2016

Background: Myocarditis is an inflammation of myocardial tissue that presents with a wide range of symptoms. Cardiovascular magnetic resonance (CMR) has become the first choice of non-invasive assessment of myocardial inflammation in suspected pts. Aims: The aim of this study was to report clinical, paraclinical and follow up data observed in pts with acute myocarditis confirmed by CMR in a single center.  Methods: We retrospectively studied27 pts admitted for acute myocarditis between November 2010 and November 2012. All pts had ECG, echocardiography and CMR. Ultrasensitive cardiac troponin and CRP were measured. Coronary angiogram was performed in case of acute myocardial infarction-like syndrome or in the presence of CV risk factors. We reviewed the files of the hospital out-patient clinic and contacted the pts or their cardiologists by phone for those followed outside the hospital. Results: There were 23 males (85.2%) and 4 females, aged 36 ± 19 yrs. ST elevation was found in17 pts (62.9%). All had elevated cardiac troponin. Echocardiography showed abnormalities of wall motion in16 pts (59.2%). Mean LVEF on CMR was 53.96 ± 9.9% and late gadolinium enhancement was in lateral in 80%, in inferior in 10% and anterior or apical wall in 10%. Coronary angiogram was normal, performed in14 pts (51.8%). Complications included VT in4 pts (14.8 %), AF in 2, and cardiac tamponade in 1. Follow-up was obtained for23 pts (85%).One died for pulmonary embolism on lung cancer. All others had a favorable evolution. Conclusion: Our study showed that myocarditis affects in majority young and male patients. CMR appears as the main modality of diagnosis. Coronary angiogram is mandatory in case of CV risk factors and/or myocardial infarction-like presentation. Evolution is often favorable. Optimal medical therapy is still to be defined. Pts can be considered as cured in the absence of chest pain and in case of normalization of echocardiography and/or CMR at follow-up.
KNOWLEDGE, ATTITUDES AND PRACTICES FOR PREVENTION OF STDS AND EARLY PREGNANCY IN ADOLESCENTS FROM A PUBLIC SCHOOL IN SALVADOR, BAHIA
Authors: Lins Liliane , Jesus Santos Ramona De , Hirakawa Vieira Yuki Tany
Published: April 2016

The aim of this study was to describe the knowledge, attitudes and practices of adolescents in relation to Sexually Transmitted Diseases and adolescent pregnancy prevention. This study enrolled 164 students from a public school in Salvador, Bahia, Brazil. An anonymous questionnaire was developed by the authors and used for data collection. Women comprised 59.5% of the study population and the average age  was 17 years old. Only 23% and 34% of the students indicated HBV and HTLV as STDs, respectively. HIV was identified as STD by 84.5% of the students, while 68.3% believed that the disease could be transmitted through blood donation. Only 64.6% of the students reported consistent condom use. Hormonal contraceptive methods were identified by students as a preventive method to STD. The students' knowledge about the theme of the study showed to be unsatisfactory. Attitudes and practices of students can contribute to greater exposure to STD.
MICROALBUMINURIA IS NOT ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN OBESE AND OVERWEIGHT WOMEN, BUT IS STRONGLY CORRELATED WITH FASTING GLYCEMIA
Authors: Bagano Menezes Rômulo , Ribeiro Sampaio Raphael , Guimarães Armênio , Lima Olivieri Lucas , Lourdes Lima Maria De , Marice Ladeia Ana
Published: April 2016

This study aimed to evaluate the association between endothelial dysfunction and microalbuminuria levels in overweight and obese women. Methods: This cross-sectional study analyzed secondary data of patients with BMI ≥ 25 Kg/m2 who had microalbuminuria and endothelial function test already performed and inserted into the survey database. The endothelial function was evaluated by reactive hyperemia test (endothelium-dependent vasodilation). Results: This study included 41 women aged of 53 ­± 11 years, BMI of 32.56 ± 5.06 Kg/m2, WC  of 100.36 ± 23.21 cm. There was no correlation between microalbuminuria and endothelial function. A multivariate logistic regression analysis identified   glucose fasting (β = 0.804; p < 0,00,1) and HDL (β = - 0.309; p = 0.048) levels  as independent predictors of microalbuminuria. Conclusion: Microalbuminuria is not useful as a marker of subclinical atherosclerosis in this population, however can be associated to glucose fasting and HDL levels.
PROVIRAL LOAD OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE 1 (HTLV-1) AND COMORBIDITIES IN ASSYMPTOMATIC CARRIERS
Authors: Alves Menezes Raonne Souza Almeida , Galvão Castro Filho Bernardo , Rios Grassi Maria Fernanda
Published: April 2016

This study aimed to describe comorbidities and symptoms of asymptomatic HTLV-1-infected patients according to the proviral load. Medical records were revised and patients categorized in high and low proviral load groups: >5% and <5% -infected cells, respectively. Frequency of symptoms was quantified. A total of 64 patients were evaluated. Twenty three (36%) patients had high proviral load. All patients had clinical abnormalities reported in the medical records. The most frequently comorbidities were hypertension (37.5%) and depression (25%) and the most frequent symptoms were neurological (82.8%) and ophthalmologic (65.6%). There were no differences in the frequencies of clinical manifestations in patients with low and high proviral load, except for urinary retention, that was more prevalent in the group with high proviral (34.8%). In summary, patients infected with HTLV-1 asymptomatic have a wide spectrum of clinical abnormalities and should be closely followed in order to identify the development of HTLV-1-associated diseases.
A RESTRICTED GLÚTEN AND CASEIN DIET FOR THE TREATMENT OF AUTISM: WHAT ARE PARENTS LOOKING FOR? – DIET AND AUTISM
Authors: Penalva Costa Serra Juliane , Pereira Pondé Milena , Ramos Daltro Mônica , Oliveira Celestino Meline Ivone , Machado Junior Samuel Bezerra
Published: April 2016

This study aims to understand parents perceptions of the importance of  restricted glúten and casein diet for the treatment of autism. The study sample consisted of mothers and teachers of five children / adolescents with autism. All the mothers reported some improvement in the children due to the diet, while teachers attributed any improvement to their own work or family support. Only one of the mothers related the search for a diet as treatment to a specific explanatory model for the disease. For mothers, the difficulties of their children leads to a sense of frustration and impotence facing autism. It remains, however, hope, revealed by the search for therapeutic options, which is expressed by the demand of the diet. Teachers highlighted the potential of these children and their positive development with the pedagogical work. Both mothers and teachers highlighted their lack of knowledge regarding the cause of autism. Diet appears as one more form of treatment in the quest of mothers searching for improvement in their autistic children, despite lacking a connection to a specific explanatory model about the disease for the vast majority of mothers.
EPIDEMIOLOGICAL DATA OF PERTUSSIS IN BRAZIL IN THE LAST FIVE YEARS - 2007 TO 2011
Authors: Araújo Sena Flavia De , Ramos Ferrer Suzana , Nunes Guerreiro Hygia Maria
Published: April 2016

Pertussis is an acute infectious disease that affects the respiratory tract. Our objective was to analyze the data on pertussis from 2007 to 2011 available online on the National Information System of Notifiable Diseases - SINAN (Sistema de Informação de Agravos de Notificação). Despite being preventable by vaccination, pertussis still has an incidence of 7.9/100,000 among babies under twelve months, with a lethality rate of 2.4% for this age group. There were no significant differences between sexes. Data analyzed demonstrated a seasonal variation with greater number of cases observed on transition from spring to summer months, October through December. The year 2011 recorded the highest number of cases. The national program of immunization has obtained a great decrease of cases of pertussis and other preventable diseases in children. Nonetheless a greater effort of education and orientation for mothers need to be done to prevent unnecessary deaths.
TYPE 2 DIABETES MELLITUS PREVENTION – PRESCRIPTIONS OFF-LABEL
Authors: De Oliveira Andrade Luis Jesuino , Santana de Melo Paulo Roberto , Alves Silva Margotto Mércia , Vinhaes Bittencourt Alcina Maria
Published: April 2016

The prescribing a drug without the indications for which the drug was originally approved by regulators is internationally known as prescribing “off-label”. Objective: To describe the off-label prescriptions in type 2 diabetes (DM2) prevention, reported international scientific literature, through an integrative bibliographical review. Method: An integrative review was made by searching the Medline international database for review of manuscripts. Selection of these databases was based on the wide range of journals covered by each of them and our goal was to provide an overview of the scientific production devoted to the topic over the timeframe under analysis. The following inclusion criteria were considered during the review: articles published between January 1985 and June 2013; use of the keywords “off-label use” OR “off-label” OR “off-label prescribing” OR “diabetes prevention” OR “prevention” MeSH “diabetes mellitus” entered into the search form, and availability of an abstract in English. Results: A total 852 scientific productions were identified, and 30 studies were selected by contain information about the off-label prescriptions in DM2. Conclusion: The practice of off-label prescribing itself has notable benefits. In some situations, an off-label prescription is the only treatment available to a patient, either because a more targeted drug is does not exist, or because other methods of treatment are ineffective or unavailable due to patient intolerance. In these situations, off-label uses of drugs provide the only chance of restored health.
TETANUS – AN EVALUATION OF EPIDEMIOLOGIC DATA IN BRAZIL
Authors: Do Patrocínio Dias Paula , Ramos Ferrer Suzana , Nunes Guerreiro Hygia Maria
Published: April 2016

Tetanus is an infectious preventable disease caused by Clostridium tetani that still occurs in large numbers in Brazil and has high mortality rates. Epidemiological data on morbidity and mortality of accidental and neonatal tetanus in Brazil from 2008 to 2011 were collected from the System of Information of Notifiable Diseases available on line. There were 1299 cases of accidental tetanus cases with 419 (32%) deaths. Men aged 20 to 59 years were most affected. High numbers of accidental tetanus areprobably related to more exposure to risk factors. The lack of specialcampaigns for tetanus revaccinations every ten years is another important factor. The fewer number of cases of neonatal tetanus (23) is related to the success of governmental vaccination program targeted to this age group. Despite low numbers, death rate is high, 65% among neonatal cases.
THYROID HORMONE CELL-MEMBRANE TRANSPORTERS DEFECT: A NOVEL GENETIC SYNDROME OF THYROID HORMONE RESISTANCE
Authors: Da Silva Medeiros Mateus Fernandes , Estrela Ramos Helton
Published: April 2016

Many studies has confirmed the crucial role of thyroid hormone transporters for TH action in human target cells. The importance was better understood by observing the phenotype in patients harboring mutations of the monocarboxylate transporter 8 (MCT8) gene immediately linked to Allan Herndon-Dudley Syndrome (AHDS), in which severe neurological findings are associated with abnormal Thyroid hormone levels. The disease is X-chromossome linked, with males presenting a homogeneous neurological psychomotor phenotype and mental retardation associated with low serum T4 and elevated T3 levels. The mechanism of disease is still obscure and either the physiopathology as the existent therapeutic options need to be better studied.
EFFECT OF SMOKING ON THE PERIODONTAL MICROSURGERY TECHNIQUE ON THE TREATMENT OF GINGIVAL RECESSION
Authors: Araújo Barbosa Renata De , Dourado Mônica , Azoubel Maria Cecília , Santos Tunes Roberta , Del Peloso Ribeiro Érica , Bittencourt Sandro , Rocha Tunes Urbino Da
Published: April 2016

This paper aims to evaluate the effects of smoking on periodontal microsurgery technique using the subepithelial connective tissue graft (SCTG) for treatment of gingival recession on smokers. 14 patients nonsmokers and 12 smokers were selected, presenting Miller’s Class I and II gingival recession ≥ 2.0 mm. For both groups, the subepithelial connective tissue graft was used with the aid of a surgical microscope. The clinical parameters of width and height of the gingival recession, height and thickness of keratinized tissue, probing depth and clinical attachment level were evaluated before and six months after surgery. At the end of the study, there were obtained an average percentage of 96.66% of root coverage on nonsmokers and 82.49% on smokers (p=0.03). Complete root coverage was observed in 78,57% and 50% of patients, respectively. Therapy can benefit both groups, but smokers have less favorable outcomes to root coverage with periodontal microsurgery using the SCTG.
NONSYNDROMIC CLEFT LIP AND/OR PALATE. THE ROLE OF FOLIC ACID 30
Authors: Hoshi Ryuichi , Alves Luis Marcelo , Sá Jamile , Peixoto Medrado Alena , Castro Veiga Patricia De , Almeida Reis Silvia Regina de
Published: April 2016

The nonsyndromic cleft lip and/or palate (NSCL/P) is a common congenital orofacial defect of multifactorial origin with involvement of genetic and nutritional factors. The presence of genetic polymorphisms in enzymes that metabolize folic acid and vitamin supplements used to prevent these anomalies have not yet been well established in the literature. The aim of this study was to conduct a review of the literature about the role of folate and gene polymorphisms in the metabolic pathway of folic acid as regards the occurrence of NSCL/P. We reviewed theoretical material that addressed data on these topics. According to the studies analyzed in the literature, there was no consensus with regard to the protective effect of supplemental folic acid taken in the periconceptional period in the prevention of NSCL/P. The studies that evaluated defects in genes involved in folate metabolism, found an association of some polymorphisms with NSCL/P in different populations.
CLINICAL AND SOCIAL IMPACT OF BRAZILIAN TEENAGE PREGNANCY
Authors: Sampaio Fabiana Sarpa de Castro Peixoto , Novais Maressa Santos , Ferrari Oliveira Vanessa , Brito Milena Bastos
Published: April 2016

Objectives: To verify the correlation between low birth weight, prematurity, number of prenatal visits and type of delivery and maternal age (Adolescents versus young adults), in the city of Salvador – Bahia, Brazil; and in the whole Brazilian territory, in 2011. Methods: Population based study, descriptive and comparative, based on secondary data available in the database of the Information System on Live Births (SINASC), which was generated by the Department of the Health System of Brazil (DATASUS). The group analyzed comprises all the newborn children of parturients aged between 10 and 34 years. The variables were categorized as: maternal age (10-14; 15-19 and 20-34 years-old); delivery route (vaginal or cesarean); birthweigh (< 2,500g; between 2,500g and 3,999g; ≥ 4000g); number of prenatal visits (None, 1 to 6, ≥ 7). Results: There was a downward trend in vaginal delivery, in Salvador and in Brazil, among the three groups analyzed. Prematurity rates (<37 weeks) as well as low birth weight rates (< 2,500g) in Salvador were higher than those in Brazil in both age groups studied. In Brazil, the rates of individuals who attended the ideal minimum number of prenatal care program were 42.1% among adolescents (10-14 years old) and 65.4% among young adults (20-34 years old) women. In Salvador, those rates were 15% and 19%, respectively. Conclusion: Pregnant adolescents from Brazil, and Salvador also, had higher rates of prematurity, low birth weight and lower adherence to prenatal care program compared with women in the age range considered ideal for pregnancy.
SPLENIC CYST
Authors: L. Garcia Larissa , L. Lomanto Fernanda , Simões da Rocha Mata Felipe , Mendonça Dilton
Published: April 2016

Background: Splenic cysts are rare in children. They are classified into primary and secondary, also called pseudocysts. The primary feature capsule and can be congenital, vascular or neoclassical. The diagnosis, in most cases, is incidental because it is asymptomatic clinical status. The diagnosis is confirmed by Ultrasound and / or Computed Tomography (CT) of the abdomen. Case Report: Patient, I.T.S.A, female, 11 years old, complains of increasing abdominal size. The diagnosis of splenic cyst was confirmed with an exploratory laparotomy. The pathology suggests reactive mesothelial hyperplasia. The patient underwent a total splenectomy and recovered without complications. Conclusions: Splenic cysts are incidental findings, most of the times it has been an asymptomatic clinical status. In the clinical case described, the patient showed a significant increase in the abdomen. She underwent exploratory laparotomy and, consequently, total splenectomy, which is the standard treatment in cases of giants splenic cysts.
The tocography variants of uterine activity hyperstimulation
Authors: Voskresenskiy Sergey Lvovich , Tesakova Marina Leonidovna , Shilkina Yekaterina Viktorovna
Published: April 2016

We performed an analysis of 85 histories of labor. Depending on perinatal outcome and application of uterotonics all stories of labor were divided into 3 groups. We present typical signs and shapes of uterine activity hyperstimulation in the application of uterotonic in labor. We established that with the appearance of any signs of hyperstimulation, it is necessary to limit or suspend the infusion of drug or to revise the plan of labor conduction in favor of the Cesarean section.
CURRENT STATE OF THE PROBLEM OF THE LABORATORY DIAGNOSTICS OF UROGENITAL TRICHOMONIASIS
Authors: Grigoryev Aleksey Nikolayevich
Published: April 2016

The laboratory diagnostics of urogenital trichomoniasis is an actual problem of modern microbiology of infections of the reproductive tract. In the review, literature data on methods of microbiological diagnostics of trichomoniasis are presented, which include microscopy of wet mount and stained preparations, culture techniques, immunological methods and nucleic acid amplification tests.
ROLE OF MYOMECTOMY IN INFERTILITY TREATMENT
Authors: Dolinskiy Andrey Kirillovich
Published: April 2016

The Up to now, the role of uterine fibroids in the genesis of infertility and IVF failures is the subject of debate.Analysis of literature demonstrated that surgical strategy in patients with uterine myoma and infertility should be individualized. Along with the classic indications for myomectomy in women with infertility there are additional indications:
Combined therapy of extensive genital endometriosis with aromatase inhibitors
Authors: Yarmolinskaya Mariya Igorevna , Molotkov Arseniy Sergeyevich , Durnova Anna Olegovna , Polyakova Viktoriya Olegovna , Kvetnoy Igor Moiseyevich , Bezhenar Vitaliy Fedorovich
Published: April 2016

The article represents our experience in evaluation of aromatase activity in endometriotic lesions. We revealed that the most important parameter in evaluating aromatase activity is the area of its expression. Increased activity of this enzyme in the foci of endometriosis was identified, which proved the prescription of aromatase inhibitors in postoperative period for 68 patients of reproductive age with genital endometriosis. It was shown that the combined therapy of endometriosis-aromatase inhibitors and progestagens (19-nortestosterone derivatives) is effective, safe and well tolerated way of treatment of the disease, but, undoubtedly, this scheme requires further research
The modern approach to the problem of adhesive disease in women of reproductive age
Authors: Shatova Yevgeniya Stanislavovna
Published: April 2016

Whatever reasons of adhesions are, ones are a major cause of pelvic pain, infertility and ovarian failure. Though the researches of the pathophysiological mechanisms of growth of adhesions are going on the attempts to determine effective methods to prevent adhesions do not rule to expected results. Advances in molecular biology identify number of biologically active molecules that regulate the inflammatory response, angiogenesis and tissue reconstruction. Those are crucial for normal peritoneal wound healing or for growth of tissue fibrosis.
Methods of osteopathy in complex preparation for labor
Authors: Mozgovaya Yelena Vitalyevna , Mishina Svetlana Vladimirovna , Vinogradova Oksana Anatolyevna , Patrukhina Natalya Aleksandrovna
Published: April 2016

The efficiency of osteopathy methods is carried out by preparation of pregnant organism for labor. 65 pregnants were included in research with full-term pregnancy, without heavy somatic and obstetric complications. Pregnants at whom as complex preparation for labor along with medicine therapy (spazmolytics, laminarias, antygestagenes, physical therapy) were applied osteopathic methods were included In the main group (n = 36). In group of comparison (n = 29) only medicine therapy was applied. At women in labor who have received complex preparation for labor with the use of osteopathic techniques in comparison with group, receiving only medicine therapy, the increase in speed of uterine cervix dilatation at 0.2 cm/h in latent and active phases of labor, reliable decrease in frequency of uterine activity anomalies and fetal hypoxia, and, as a result, decrease by 3 times of emergent Cesarean section frequency is detected. Decrease in frequency of perineotomiya and ruptures of uterine cervix are noted.
To the question about the influence of regional anesthesia on the contractile function of the uterus
Authors: Pervak Vladimir Anatolyevich
Published: April 2016

Was held a retrospective analysis of 215 histories parturient women undergoing caesarean section under spinal anesthesia and under general anesthesia in combination with artificial ventilation of the lungs. For both methods of anesthesia maintenance was held compared signs, who indirectly characterizing the contractile function of the uterus ( the amount of blood loss, the amount and the quality of uterotonic therapy, the dynamics of the preoperative and postoperative indicators of hemoglobin, hematocrit, and erythrocytes). As a result of the conducted research it was shown that the amount of blood loss, the amount of and qualitative composition of uterotonic therapy, the dynamics of the preoperative and postoperative indicators of hemoglobin, hematocrit, red blood cells in caesarean sections performed under spinal anesthesia and under General anesthesia in combination with artificial ventilation of the lungs authentically did not differ.
Rol' kletok vrozhdennogo immuniteta v obespechenii uspekha beremennosti na rannikh srokakh gestatsii
Authors: Sotnikova Natalya Yuryevna , Antsiferova Yuliya Stanislavovna , Kroshkina Natalya Vladimirovna , Voronin Dmitriy Nikolayevich
Published: April 2016

The innate immunity plays an important role in the development and maintenance of the immune balance at the fetal-maternal interface. NK and macrophages dominate in decidua at early stages of pregnancy. Interaction of innate immunity cells and invasive cytotrophoblast is a key factor defining regulation of maternal immune response and the development of placental tissues at early gestation period.
Medico-psychological monitoring of the family in the period of expectation of the child
Authors: Shikhova Yelena Pavlovna , Malgina Galina Borisovna
Published: April 2016

The author, using interdisciplinary approaches, explores the peculiarities of interaction in families, waiting for the child. The changes affect all members of the family, and they are associated with changes in the physiological, psychological and socio-cultural status. They occur on the background of the biological and neuroendocrine restructuring of the woman's body that is associated with the expectation of the child.
Ovarian aromatase activity in endometriosis
Authors: Denisova Valentina Mikhaylovna , Potin Vladimir Vsevolodovich , Yarmolinskaya Mariya Igorevna , Timofeyeva Yekaterina Mikhaylovna
Published: April 2016

Aromatase is the key enzyme, which converts androgens into estrogens. To study the role of aromatase in pathogenesis of endometriosis 57 patients and 15 healthy women of reproductive age were examined. Aromatase activity was detected by reaction of estrogens on aromatase inhibitor letrozol intake. Ovarian source of detected aromatase activity was proved by suppression of reaction on letrozole intake during therapy with gonadotropin- releasing hormone agonist. Aromatase activity in recalculation on antral follicle in endometriosis patients withII–IV stages was higher than in healthy women, though total ovarian aromatase activity was not differed from control group because of low number of antral follicles in endometriosis patients. The disturbance of folliculogenesis in endometriosis is connected probably with hyperestronaemia, which has ovarian and extragonandal origin.
Possibilities and limits of modern metods of diagnosis of distant metastases locallyadvanced cervical cancer
Authors: Kargopolova Margarita Vitaliyevna , Maksimov Sergey Yanovich , Berlev Igor Viktorovich , Khadzhimba Anzhella Slavikovna , Chepik Oleg Fedorovich , Novikov Sergey Nikolayevich , Gershfeld Eduard Dmitriyevich , Vyshinskaya Yekaterina Aleksandrovna
Published: April 2016

A retrospective study of 245 cases of recurrent cervical cancer, in every third case was detected metastases in paraaortic lymph nodes. Given these results, a prospective study aimed at optimizing the staging of cervical cancer Ib1–IIIb stages. Analyzed 48 clinical cases of patients with locally - common forms of cervical cancer, which before the combined treatment paraaortic lymphadenectomy was performed through laparoscopy with subsequent histological examination of surgical specimens. At the preoperative stage, to identify distant metastasis in para-aortic lymph nodes, patients were examined by various methods of radiation diagnosis. The sensitivity of MRI was 75 %, specificity 79 %, sensitivity and specificity of ultrasonography – 75 % and 93 %, respectively. The positive predictive value of the test was 25 % MRI, ultrasound – 50 %. Performing paraaortic lymphadenectomy with the greatest possible to individualize treatment policy and, as a consequence, to improve the results of combined treatment of patients with locally-common forms of cervical cancer. The use of laparoscopic approach, given the short period of rehabilitation, has not led to the postponement of chemoradiotherapy.
Influenza A virus reproduction in humanendometrial cells
Authors: Durnova Anna Olegovna , Kadyrova Renata Anvarovna , Danilenko Darya Mikhaylovna , Dyukov Maksim Igorevich , Martyntseva Vera Aleksandrovna , Smirnova Tatyana Dmitriyevna , Yeropkin Mikhail Yuryevich , Kiselev Oleg Ivanovich
Published: April 2016

Study of replication of influenza A viruses (IAV) of A(H3N2) and A(H1N1)pdm subtypes in human endometrial cells was performed. It was shown that endometrial infection with IAV strongly depends on the multiplicity of infection and causes substantial changes in functional activities of these cells. Moreover endometrial cells of proliferative phase (day 8) were more sensitive to IAV infection than cells from secretory phase of menstrual cycle on day 19th.
Intraplacental blood flow features inphysiological pregnancy
Authors: Zakurina Anna Nikolayevna , Pavlova Natalya Grigoryevna
Published: April 2016

The article presents data of intraplacental blood flow three-dimensional power Doppler indexes in different placental zones in the second half of physiological pregnancy. We described results of comparison three-dimensional power Doppler indexes of intraplacental vessels in different placental zones at odds.
Prognoses of the pathological postpartum engorgement of the woman breast
Authors: Alekseyev Nikolay Petrovich , Ilin Vladimir Ivanovich , Talalayeva Nadezhda Yevgenyevna
Published: April 2016

The results of this study demonstrate that premenstrual pain (“premenstrual engorgement”) the woman mammary gland may be the main index of the prognoses for pathological postpartum engorgement.
FOLATE METABOLISM IMPAIRMENT IN SMOKING PREGNANT WOMEN
Authors: Semenova Tatyana Valeryevna , Milyutina Yuliya Pavlovna , Arutyunyan Aleksandr Vartanovich , Arzhanova Olga Nikolayevna
Published: April 2016

Tobacco smoking is one of the pressing issues of public health. Russia ranks among the countries with a very high smoking rate. Smoking frequency among pregnant women in St. Petersburg is about 26.4%, among which 18.9% of the women smoke every day, and the rest 7.5% of them on the occasion. Complications from pregnancy (threatening miscarriage, premature delivery, anaemia) and from labour and delivery (labour abnormalities) in the smoking women occurs at almost twice the rate in those non-smoking, threatening miscarriage and anaemia notably having a more severe clinical picture and being more reluctant to the therapy. Smoking is one of the risk factors of hyperhomocysteinemia, which is in turn a marker of the folate metabolism impairment in the organism. It has been shown that homocysteine plasma level increases in the smoking pregnant women. Besides, a significant decrease in folate plasma level has been found in the same women. It is a folate deficiency that most of all raises homocysteine level in blood plasma. It has been proved that elevated homocysteine level has a direct toxic effect on the endothelium. Microthrombosis and microcirculation loss result in a series of obstetric complications. In late pregnancy, hyperhomocysteinemia causes chronic fetoplacental insufficiency and chronic intrauterine hypoxia. Therefore, many complications from pregnancy, such as gestosis and fetoplacental insufficiency, are associated with hyperhomocysteinemia, which is most probably caused by the smoking derived folate metabolism impairment. Supplementary folate and vitamin B complex therapy may possibly improve the pregnancy and delivery outcome in the pregnant women with high homocysteine plasma level. This, however, requires supportive clinical trials. Smoking cessation at birth spacing and prevention of hyperhomocysteinemia must be an essential condition for favourable prognosis for pregnancy.
The use of synthetic materials in urogynecology
Authors: Gvozdev Mikhail Yuryevich
Published: April 2016

This review is dedicated to the use of synthetic materials in urogynecology. Presents historical data, as well as information about the chemical structure and the production of polymers, classification and their use in medicine and in particular in urogynecology at the present time. Shows the leading role of polypropylene in the treatment of urinary incontinence and pelvic organ prolapse.
Effect of labor stimulation on fetal cerebral hemodynamics
Authors: Ivshin Aleksandr Anatolyevich , Gumenyuk Yelena Georgiyevna , Shifman Yefim Munevich , Kolybina Polina Vladimirovna , Garloyeva Yuliya Nadirovna
Published: April 2016

Article evaluates the state of the cerebral blood flow of the fetus in pregnant women with primary uterine dystocia, require correction oxytocin. The study included 52 mothers who had primary uterine dystocia. Cerebral hemodynamics in the fetus was studied by the method of Doppler ultrasound in the ultrasound scanner «LogiqBookXP». Correction of uterine activity, as measured by infusion of oxytocin concentration of 10 mU of oxytocin 1 ml of saline. These results reveal a violation of fetal cerebral perfusion.
Psychological care in a comprehensive approach to solving the problems of reproductive health
Authors: Bloch M E , Dobryakov I V
Published: April 2016

The problem of complex medical and psychological interaction in addressing reproductive health. The groups of patients in need of psychological and psychiatric help, the main tasks of the psychologist working with them.
Diskussionnye voprosy vedeniya zhenshchin s antifosfolipidnymi antitelami pri primenenii VRT
Authors: Mirashvili Marina Ivanovna , Zainulina Marina Sabirovna , Selkov Sergey Alekseevich , Gzgzyan Alexander Mkrtichevich
Published: April 2016

There are many controversies in the management antiphospholipid antibodies-positive women undergoing assisted reproductive technologies. Controversial and important is not only the effect of antiphospholipid antibodies (APA) on the success of IVF, but also approaches to the management of this group of women. The aim of this work was to study the prevalence of antiphospholipid antibodies in women with 3 or more IVF failures and effectiveness of IVF in women with APA treatment with membrane plasmapheresis before IVF and intravenous immunoglobulin during IVF. In women with 3 or more IVF implantation failure APA were detected in 35.95 % of cases. The use of intravenous immunoglobulin along with the standard therapy is a safe and effective for improvement of IVF outcomes in women with antiphospholipid syndrome (APS) or the presence of APA. The most effective is a combination of the membrane plasmapheresis therapy before IVF and intravenous immunoglobulin during IVF standard therapy including LMWH and low-dose aspirin in IVF protocol. This therapy in patients with the presence of APA increases the pregnancy rate after IVF to 46.15 %.
High perinatal risk in two ethnic groups during pregnancy: associations with the state of the system «Lipid Peroxidation-Antioxidant Defense»
Authors: Kolesnikova Lubov Iljinichna , Darenskaya Marina Aleksandrovna , Grebenkina Lyudmila Anatolejvna , Protopopova Natalia Vladimirovna , Dolgikh Maria Igorevna
Published: April 2016

The high perinatal risk in Buryat and Russian ethnic groups during pregnancy has been studied. In the pregnant Russian women compared to thosw of the Buryat ethnic group, the following risk factors prevailed: more than 3 abortions in history, cystic changes in the ovaries, essential arterial hypertension in relatives, premature birth. It has been found that activation of lipid peroxidation in the pregnant Buryat women is associated with the increased total antioxidant, α-tocopherol and SOD activities in blood.. In the pregnant Russian women components of antioxidant defense system. The decrease slightly, while lipid peroxdation products increase comparison of the lipid peroxidation components of in the two ethnic groups showed an increase in the lipid peroxidation products and retinol in the pregnant Russian women during all trimesters of pregnancy. It may be concluded that the risk factors create unfavorable conditions for changes in the lipid peroxidation-antioxidant defense system, which determines the development of many complications of pregnancy and child birth.
RATIONAL ANTIBACTERIAL THERAPY DURING PREGNANCY AND LABORS
Authors: Kucherenko Marina Anatolyevna
Published: April 2016

The provision of clear guidelines on the application of antibacterial drugs in pregnancy leads to a significant reduction of the risk of infection of mother and fetus, of the development of toxic and allergic reactions, as well as to the containment of the formation and spread of antibiotic resistant strains of microorganisms.
Significance of social and reproductive factors in mother-to child transmission of HIV
Authors: Niauri Dariko Alexandrovna , Musatova Ekaterina Vladimirovna , Kolobov Andrey Viktorovich , Martirosyan Margarita Mihailovna , Karev Vadim Evgenievich , Zinserling Vsevolod Alexandrovich
Published: April 2016

The retrospective analysis of pregnancy and delivery at 12 HIV-positive mothers who have performed mother-to-child transmission. In reference group — 11 HIV-positive women who have given birth to not-infected children. The study of placentae was done with immunohistochemical methods. For placentae of the infected children decrease of expression of CD31 and CD68 and increase of expression of TGF-в1 was typical. Leading factor in transmission of HIV is absence of ARVT.
The role of progestogens in obstetrics practice
Authors: Repina Margarita Aleksandrovna , Bobrov Sergey Aleksandrovich
Published: April 2016

Objective: in this paper reviews the evidence for safety and efficacy of use of any progestogens in each of these indications. Progestogens may be use for the prevention of preterm labour, but not only for therapy spontaneous abortion.
Perinatal infections in the Russian Federation. Screening strategies: problems and prospectives
Authors: Savicheva Alevtina M
Published: April 2016

The article describes principal problems of the diagnosis and prevention of perinatal infections in the Russian Federation. Data on the prevalence of infectious diseases in pregnant women, the ways of transmission of infection from mother to fetus and newborn infant, as well as adverse effects are discussed. Possible ways of solving the current problems are suggested, such as the development of standards and algorithms of diagnosis and prevention of infections during pregnancy planning and early pregnancy terms.
Subchorionic hematoma. Causes, pathogenesis, diagnostic and treatment management
Authors: Kovalyova Julia Viktorovna
Published: April 2016

Threatened abortion is one of the most common complications of early pregnancy. In the presence of a live embryo, the most frequently encountered sonographic finding is a subchorionic hematoma. Resent studies suggest that the presence of intrauterine hematoma during the first trimester may identify a population of patients at increased risk for adverse pregnancy outcome. In the review the etiology, pathogenesis of subchorionic hematoma and diagnostic and treatment management of patients with such pregnancy complication are described.
Efficiency of application of metformin and its combination with combined oral ontrceptive, containing drospirenone, in women with polycystic ovary syndrome
Authors: Soboleva Yelena Leonidovna
Published: April 2016

The article represents results of monotherapy with metformin, as well as combined treatment with metformin and combined oral contraceptive (COC), containing drospirenone, in patients with polycystic ovary syndrome (PCOS). In general, treatment was given to 42 patients with PCOS. Combined treatment was prescribed to 18 of them. Equally high efficiency of both schemes of treatment in correction of disorders of carbohydrate metabolism was demonstrated. But efficacy of metformin alone in restoration of ovulatory menstrual cycle was low – ovulation occurred in 3 patients (13 %) and only two women (8.7 %)became pregnant. These results do not allow recommendation of monotherapy with this medication for restoration of fertility. Implication of combined therapy has shown benefits in normalization of menstrual cycle, ultrasound structure and volume of ovaries. COC with drospirenone also has antiandrogenic properties. So combination of metformin with COC, containing drospirenone, can be recommended as a first-line therapeutic option for patients with PCOS and impaired carbohydrate metabolism.
Abdominal delivery as a medical and social problem of contemporary obstetrics
Authors: Orlova Valentyna Semyonovna , Kalashnikova Irina Vladimirovna , Bulgakova ElenaValentinovna Valentinovna , Voronova Yuliya Vasilievna
Published: April 2016

The frequency of cesarean section as the instrument of decrease in perinatal mortality, in many countries with the high and average level the income I surpassed reasonable limits. The systematized data of foreign authors concerning the most discussed aspects of the problem are submitted: the reasons of the global increase in the level of operational childbirth, consequences for the health of the mother and the newborn, and also ways and expediency of decrease in their level. Robson classification is widely used in international practice. It gives an opportunity to compare the indications for cesarean section in different countries and regions.
Features of uterine scar after cesarean section depending on the time of delivery
Authors: Telegina Irina Valeryevna , Pavlov Roman Vladimirovich , Selkov Sergey Alekseyevich
Published: April 2016

The article includes the results of comparative study of uterine scar after cesarean section depending on the time of surgery – at term pregnancy or during the term labor. There was more intense neoangiogenesis in the uterine wound at early postoperative period and the number of patients with morphologically “sufficient” uterine scar increased in 2 times when cesarean section was performed at term labor.
Comparative assessment Of life quality of patients after the correction of genital prolapse with different synthetic implants
Authors: Bezhenar Vitaliy Fedorovich , Guseva Yevgeniya Sergeyevna , Tsypurdeyeva Anna Alekseyevna , Rusina Yelena Ivanovna , Tsuladze Liliya Karlovna
Published: April 2016

There was made a comparative analysis of surgical complications, life quality of patients and also sexual life quality after the correction of genital prolapse with the implants Prosima™ and Prolift™. There were reflected the advantages of the operation when the implants Prosima™ were used while correcting the genital prolapsed of III stage compared with the use of the implant Prolift™. There was shown the success of the operation Prosima™, its safety because of little invasiveness and few number of complications, satisfaction of the patients with the results of the treatment and also the improvement of the life quality and restoration of sexual activity.
Modern concepts of epidemiologyHPV-infection
Authors: Semenova Kseniya Yevgenyevna , Khachaturyan Armine Robertovna
Published: April 2016

Human papillomavirus (HPV) is widespread sexually transmitted infection, which is defined by high risk of contagion and high cancer potential. HPV extension depends on patiens age, residence, opportunites of diagnostics, etc. There are general methods of HPV-diagnostics such as HPV DNA testing, cytological, hystological methods, which are not always useful in detection of transitory and persistent HPV-infection forms. Nowadays, there is acute need to develop new diagnostic and prognostic methods, treatment strategies for patients from various age groups, having different infection formss.
Immunocytochemistry in diagnostics of endometrial precancer
Authors: Dzyubiy Tatyana Ivanovna , Protasova Anna Eduardovna , Raskin Grigoriy Aleksandrovich , Tsypurdeyeva Anna Alekseyevna , Tapilskaya Natalya Igorevna
Published: April 2016

Use of the method liquid-based cytology with next immunocytochemical study of endometrium is expedient for the differential diagnosis of endometrial pathology processes. The level of the gene PTEN and steroid receptors expression is higher in cases of simple hyperplasia and hyperplasia without atypia. Increase of the markers p53 and Ki67 expression was found only by atypical endometrial hyperplasia. Positive reaction on CD138 determines the inflammatory process.
Fluorescence monitoring photodynamic therapy of benign of the uterine cervix diseases associated with human papillomavirus
Authors: Khachaturyan Armine Robertovna , Papayan Garri Vazgenovich , Petrishchev Nikolay Nikolayevich
Published: April 2016

Photodynamic therapy (PDT) is defined as minimally invasive technique of the treatment of uterine cervix diseases associated with human papillomavirus (HPV). It is a method of choice in the patients of reproductive age. The monitoring of red fluorescence after the injection of photosensitizer during PDT provides the opportunity of control over the beginning of laser irradiation and its duration.
Vaginal microbiota at physiological microbiocenosis and with bacterial vaginosis
Authors: Nazarova Veronika Viktorovna
Published: April 2016

The article presents literature review on the problem of bacterial vaginosis, describes current methods used for bacterial vaginosis diagnosis. Especial attention is spared for peculiarities vaginal microbiota at physiological microbiocenosis and with bacterial vaginosis.
Hormonal contraception with progestagen desogestrel in women with diffuse non-toxic goiter аnd autoimmune thyroiditis
Authors: Pologoyko Galina Petrovna , Yarmolinskaya Maria Igorivna , Lekareva Tatyana Mihajlovna
Published: April 2016

The article represents influence of gestagen desogestrel on size and function of thyroid gland in women of reproductive age. Into the study we included 70 women who were prescribed gestagen desogestrel in a daily dose of 75 mg for a period of 12 months. All the patients were devided into two groups. The first group consisted of 20 women with diffuse nontoxic goiter, the second consisted of 30 women with autoimmune thyroiditis. Control group consisted of 20 women without thyroid gland pathology. Prior to therapy with desogestrel and after 12 month of treatment, serum levels of free triiodothyronine, free thyroxine and thyrotropin releasing hormone, thyroperoxidase antibodies were determined and thyroid gland sonigraphy was performed in all the patients. Obtained data show that gestagen desogestrel doesn’t influence the size and function of thyroid gland in healthy women and in patients with diffuse non-toxic goiter. In women with autoimmune thyroiditis implication of desogestrel significantly decreases blood levels of thyroperoxidase autoantibodies.
Integrated assessment haemostasis pregnant women with gestosis
Authors: Barinov Sergey Vladimirovich , Dolgikh Vladimir Timofeevich , Medyannikova Irina Vladimirovna
Published: April 2016

The parameters of the kaolinaktivirovannoy thrombelastographic at physiological gestation, moderate, and severe gestosis. The significant differences between groups for the intensification of intravascular coagulation and fibrinolysis activity. Option and the severity of the changes thrombelastographic determine the need for correction hemocoagulation violations during gestation thrombohemorrhagic to prevent complications in pregnancy.
Anti-Mullerian hormone and polycystic ovary syndrome
Authors: Nikolaenkov Igor Pavlovich , Potin Vladimir Vsevolodovich , Tarasova Marina Anatol’evna
Published: April 2016

Polycystic ovary syndrome (PCOS) is the most common form of normogonadotropic ovarian insufficiency, hyperandrogenaemy and anovulation sterility. One of the probable causes of this disease is disturbance of folliculogenesis, which is accompanied by overproduction of anti-Mullerian hormone (AMH) by ovarian tissue. There is a literature review about structure, biological properties and the role of AMH in pathogenesis of PCOS in this article.