bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Finite State Machine dalam Perancangan Perilaku Musuh pada Game 2D Platformer bertema Sejarah
Authors: Al Kautsar Muhammad Faris , Haryanto Hanny , Astuti Erna Zuni , Mulyanto Edy , Rosyidah Umi , Kardianawati Acun
Published: July 2024

Understanding of history decreases with each generation, especially among the younger generation. This happens because the delivery media used is considered less attractive. Games are considered to be an interesting educational medium to increase understanding of history in Indonesia. This research takes the theme of the history of the Islamic Mataram Kingdom. To make an educational game that is interesting and not boring, there are several things you need to pay attention to, such as the behavior of Non-Playable Characters (NPC). Dynamic enemy NPC behavior can provide players with an interactive gaming experience, making the game feel more interesting and not boring. In this research, the game created is an Action Platformer type with a method approach using Finite State Machine (FSM) to shape behavior in NPCs. The parameters used as input are the enemy's health points and the distance between the enemy and the player. The test results in this research show that the enemy's behavior patterns change according to the conditions received by the enemy NPC. These results show that the behavior of enemy NPCs in the Islamic Mataram Kingdom game "Glory of Matawis" has dynamic and interactive behavior with variations in behavioral patterns that can change according to conditions.
MANAJEMEN KEGIATAN EKSTRAKURIKULER UNTUK MENGEMBANGKAN MINAT DAN BAKAT SISWA DI MA IBADURRAHMAN MALANG
Authors: Widodo Wahyudi
Published: July 2024

MA Ibadurrahman Malang menyelenggarakan aktivitas ekstrakurikuler guna meningkatkan minat serta bakat siswa. Riset ini dilatarbelakangi oleh ketertarikan periset terhadap pengelolaan aktivitas ekstrakurikuler di sekolah- sekolah tersebut, yang kerapkali meraih keberhasilan dalam bidang ekstrakurikuler semacam dakwah, kaligrafi, serta olah raga. Dalam perihal ini pengelolaan aktivitas ekstrakurikuler sangat efisien, sebab sekolah ini sangat menekankan pada pertumbuhan partisipan didik. Tipe riset yang digunakan merupakan kualitatif. Informasi dikumpulkan dengan memakai wawancara, observasi, serta dokumentasi. Tujuan dari riset ini merupakan buat mengenali gimana pengelolaan aktivitas ekstra kurikuler buat meningkatkan atensi serta bakat siswa MA Ibadurrahman Malang. Kajian ini menampilkan kalau:( 1) Dalam perihal perencanaan, segala pengelola ekstrakurikuler di MA Ibadurrahman Malang sanggup merancang tugasnya dengan baik., antara lain muat tujuan program yang jelas, rencana kerja yang tertib, pembinaan yang baik.( 2) Dalam penerapan, MA Ibadurrahman Malang muat lapisan organisasi, pembagian tugas, fasilitas serta prasarana, serta sumber dana yang diatur dengan baik sehingga terlaksana.( 3) Sebaliknya penilaian dicoba lewat penilaian kurikulum serta penilaian murid yang dicoba minimun satu semester.
PENGARUH AUDITOR SWITCHING, DISCLOSURE DAN FINANCIAL DISTRESS TERHADAP OPINI AUDIT GOING CONCERN
Authors: Febrina Eka Berliana  , Napisah Napisah
Published: July 2024

Penelitian ini dilakukan untuk menganalisis pengaruh auditor switching, disclosure dan financial distress terhadap opini audit going concern. Penelitian dilakukan pada perusahaan cunsumer non cyclical yang terdaftar di Bursa Efek Indonesia pada tahun 2018 – 2022. Metodologi yang digunakan adalah regresi logistic karena variabel dependen dari penelitian ini berupa dummy. Pemilihan sampel dilakukan dengan menggunakan metode purposive sampling dari data sekunder berupa laporan keuangan dan ditemukan sebanyak 54 perusahaan sampel dengan jumlah pengamatan 5 tahun, sehingga total sampel dalam penelitian ini sebanyak 270 laporan keuangan. Pengujian hipotesis dilakukan dengan menggunakan aplikasi Eviews series 10. Hasil penelitian menunjukkan bahwa secara parsial auditor switching tidak berpengaruh terhadap opini audit going concern, disclosure tidak berpengaruh terhadap opini audit going concern, Financial Distress berpengaruh terhadap opini audit going concern. Secara simultan auditor switching, disclosure dan financial distress  berpengaruh terhadap opini audit going concern.
MOLECULAR DOCKING ANALYSIS AND ADMET PREDICTION Of Caesalpinia sappan COMPOUNDS AS ANTIINFLAMMATORY THROUGH CYCLOOXYGENASE-2 INHIBITION
Authors: Putri Maisarah Marisa , Rahmawati  , Andika
Published: July 2024

Selective COX-2 inhibitors have been considered safer treatments than NSAIDs for inflammation from its side effect. Sappanwood was already known for its antiinflammatory activity, but its selectivity towards COX-2 has not been tested. The purpose of this study was to determine the potential activity of compounds in Caesalpinia sappan as anti-inflammatory agents by inhibiting COX-2 and determine their ADMET’s properties through in silico study. Qulified compound from Lipinski’s rule of five evaluation would be continued to the molecular docking using Autodock Tools and ADMET prediction using SwissADME and ADMETLab. Three compounds known to have the best free bond energy (ΔG) values were Caesalpiniaphenol A, Sappankalkon, and Deoxysappanone B with ΔG values respectively (-9.36 ; -9.23 ; -9.02 kcal/mol) and their inhibition constant values of (124.44 ; 172.43 ; 244.75 nM) respectively. Amino acid residues that are known to involve to the formation of hydrogen bonds in ligands are GLN 192 and PHE518. Toxicity results showed that these three compounds were predicted to be neither hepatotoxic nor hERG inhibitors, but 3-deoxysappanone B and sappankalkon was predicted to cause AMES mutagenicity and skin sensitivity. It can be concluded that these third compound has the potential as an inhibitor of the COX-2 enzyme.
OPTIMASI FORMULA KRIM EKSTRAK ETANOL DAUN PATIKAN KEBO (EUPHORBIA HIRTA L.) DENGAN METODE SIMPLEX LATTICE DESIGN
Authors: Purwanto Aris , Amrina Fina , Riauwati Rosa
Published: July 2024

Pemilihan suatu emulgator krim merupakan faktor penting kestabilan suatu emulsi. Patikan kebo (Euphorbia hirta L.) merupakan tanaman yang dapat digunakan sebagai salah satu komponen alami dalam produk anti-aging.
Optimasi 14 formula krim dilakukan menggunakan 3 faktor optimasi yaitu ekstrak dengan rentang konsentrasi 1-3%, trietanolamin dengan rentang konsentrasi 2-4% dan asam stearat dengan rentang konsentrasi 1-3% dengan software Design Expert versi 13 metode Simplex Lattice Design (SLD). Parameter yang diukur yaitu daya sebar, pH dan viskositas.
Hasil penelitian menunjukkan bahwa formula optimum yang diperoleh memiliki nilai desirability sebesar 1,000 dengan perbandingan ekstrak 1% ; TEA 2% dan asam stearat 3%. Menghasilkan sifat fisik sediaan meliputi daya sebar 6,5 ± 0 cm, pH 5,5 ± 0 serta viskositas 17.880 ± 0,0404 cP yang memenuhi syarat yang ditetapkan oleh SNI terkait sediaan krim.
EVALUASI TEPAT PASIEN, TEPAT OBAT DAN TEPAT DOSIS ANTIPSIKOTIK PASIEN RAWAT INAP SKIZOFRENIA PARANOID DI RSJ SAMBANG LIHUM
Authors: Alexxander Alexxander , Pratiwi Restu Dwi
Published: July 2024

Skizofrenia merupakan penyakit gangguan otak parah berupa kombinasi dari halusisnasi, delusi, ketidakteraturan berpikir dan gangguan perilaku. Skizofrenia paranoid diketahui tipe paling banyak di RSJ Sambang Lihum tahun 2023.  Terapi utama untuk  pengobatan skizofrenia adalah antipsikotik dengan efek menenangkan yang kuat, mengobati gangguan perilaku termasuk psikosis. Perbaikan gejala dilihat dari PANSS- EC yang merupakan instrumen penilaian pada pasien gangguan jiwa berat/skizofrenia, sehingga evalusi ketepatan sangat penting untuk mempertimbangkan asas manfaat penggunaan klinis. Penelitian ini bertujuan untuk mengatahui persentase pola penggunaan dan evaluasi ketepatan antipsikotik terhadap outcome keberhasilan pasien skizofrenia paranoid di RSJ Sambang Lihum Kalimantan Selatan tahun 2023. Penelitian dilakukan secara observasional deskriptif dengan pendekatan retrospektif pada 110 data rekam medik pasien yang menderita skizofrenia paranoid, dengan menggunakan metode purposive sampling. Hasil penelitian menunjukan pola penggunaaan obat terbanyak kategori kombinasi tipikal-atipikal adalah haloperidol dan clozapin, ketepatan penggunaan meliputi tepat dosis 100%, tepat obat 100%, dan tepat pasien 99,1%, dengan outcome keberhasilan PANSS-EC pulang ≤ 15 adalah 100%.
A IMPORTÂNCIA DA EDUCAÇÃO EM SAÚDE PARA A PREVENÇÃO DE DOENÇAS CRÔNICAS
Authors: Lino Daniele do Nascimento , Pontes Hiara Cássia Fernandes , Bloch Fátima Valladares , Lima Clebiana da Rocha , Aquino Fábio Henrique Tomaz de , Moraes Richard Franco da Silva , Gonçalves Anannda Evellyn de Souza , Costa Victoria Melo , Donadeli Rafael Lourenço , Oliveira Laila Gabriela Carlos de , Stanescu Silvanna Raquel Marinheiro da Silva , Silva Ana Carla Gardene Moreira
Published: July 2024

A educação em saúde é uma ferramenta essencial na prevenção de doenças crônicas e na promoção de comportamentos saudáveis. Este estudo revisa sistematicamente a literatura sobre programas de educação em saúde, destacando as intervenções mais eficazes e os desafios enfrentados. Programas que combinam metodologias presenciais e digitais, personalizadas de acordo com as características culturais e socioeconômicas dos participantes, demonstram resultados significativos na redução de fatores de risco e na melhoria de indicadores de saúde. A participação ativa das comunidades e a colaboração intersetorial são elementos críticos para o sucesso das intervenções. Contudo, a sustentabilidade dos programas depende de políticas públicas robustas e apoio institucional contínuo. A análise aponta a importância de abordagens diversificadas, o uso inclusivo de tecnologias digitais e a garantia de financiamento contínuo para maximizar a eficácia dos programas educativos. Este estudo contribui para a compreensão da importância da educação em saúde e fornece diretrizes para a implementação de práticas que promovam a saúde pública de forma sustentável e equitativa.
Avanços em Oftalmologia: Revisão de Literatura sobre a Fisiologia, Abordagem e Tratamento do Olho Seco
Authors: Cizoski Carvalho Letícia , Cizoski Carvalho Gabriel , Cizoski França Olinda
Published: July 2024

Introdução: O Olho Seco, ou ceratoconjuntivite sicca (KCS), é uma condição multifatorial que afeta a superfície ocular e a produção de lágrimas, levando a desconforto e problemas visuais, e é especialmente prevalente entre idosos e mulheres pós-menopausa. Este resumo explora uma revisão de literatura focada na fisiologia, diagnóstico e tratamento do Olho Seco. Metodologia: A revisão foi conduzida por meio de pesquisa em bases científicas indexadas, com ênfase em artigos revisados e estudos relevantes. O objetivo foi identificar as principais características da condição, as classificações existentes e as opções terapêuticas mais eficazes. Desenvolvimento: O filme lacrimal, essencial para a proteção ocular, consiste em três camadas: lipídica, aquosa e mucosa. A camada lipídica, produzida pelas glândulas meibomianas, previne a evaporação da camada aquosa e é regulada por hormônios sexuais. A camada aquosa, proveniente das glândulas lacrimais principais e acessórias, fornece oxigênio à córnea e possui propriedades antibacterianas. A camada mucosa, secretada pelas células caliciformes da conjuntiva, lubrifica a superfície ocular. A alteração desta fisiologia pode ocasionar, sinais e sintomas compatíveis com o Olho Seco. Este, pode ser classificado em déficit evaporativo ou déficit aquoso, conforme o Subcomitê Internacional do Olho Seco (DEWS), e também por subsistemas (AMLEI) ou gravidade. Testes diagnósticos como o Teste de Ruptura do Filme Lacrimal e o Teste de Schirmer são fundamentais para confirmar o diagnóstico e diferenciar de outras condições oculares. Conclusão: A revisão destacou a complexidade do Olho Seco e sua influência na qualidade de vida dos pacientes. A compreensão das camadas do filme lacrimal e das classificações é crucial para um diagnóstico e tratamento eficazes. As opções terapêuticas incluem substitutos lacrimais, oclusão do ponto lacrimal, agentes anti-inflamatórios e, em casos graves, intervenções cirúrgicas. Melhorar os critérios diagnósticos e as opções de tratamento pode melhorar significativamente a gestão da condição.
AVALIAÇÃO DE INDICADORES DA ESTRATÉGIA BRASIL LIVRE DA TUBERCULOSE NO MUNICÍPIO DE IMPERATRIZ – MA.
Authors: Lucas Durand Rodrigues Ribeiro Viana  , Matheus Durand Rodrigues Ribeiro Viana  , Saulo Almeida Santos  , Lucas André Sousa Vale
Published: July 2024

Esse estudo tem como objetivo avaliar indicadores de monitoramento da tuberculose presentes na estratégia "Brasil Livre da Tuberculose", no município de Imperatriz-MA, entre os anos de 2015 a 2020, além de traçar o perfil sociodemográfico desses pacientes. Trata-se de um estudo transversal, descritivo, retrospectivo, com abordagem quantitativa. Os dados utilizados foram extraídos dos bancos de dados do Sistema de Informações sobre Agravos de Notificação (SINAN), Sistema de Informação sobre Mortalidade (SIM) e Instituto Brasileiro de Geografia e Estatística (IBGE). O perfil sociodemográfico obtido foi o de pacientes do sexo masculino, da raça preta, de baixa escolaridade e idade maior ou igual a 60 anos. No município de Imperatriz, a meta estabelecida para incidência entre os anos de 2015 e 2020, de uma redução de 20%, não foi alcançada, chegando a um aumento de 34,2%, enquanto que a meta para mortalidade, para uma redução de 35%, foi satisfeita, sendo essa redução de 67,17%. Os valores para realização de TDO e realização de cultura em casos de retratamento foram inferiores quando comparados a nível estadual e federal, enquanto que os demais indicadores apresentaram valores superiores. Foi-se observado uma relação negativa estatisticamente significativa entre a taxa de incidência e a realização do TDO.
A PRÁTICA MULTIPROFISSIONAL NO CUIDADO PALIATIVO AO NEONATO: UMA REVISÃO DA LITERATURA
Authors: Vitoria Oliveira Souza  , Maria Vanderline Pimenta Araujo  , João Victor Ribeiro de Mendonça  , Bianca Porchat de Assis Bernardo  , Eduardo de Mendonça Carvalho  , Amanda Sabrina da Silva Jinkings  , Elder Rennê Serrão de Oliveira  , Maria Ricarda Costa de Oliveira  , Larissa Barreto Cortez  , Nathália Telles Paschoal Santos
Published: July 2024

Os cuidados paliativos aplicados em neonatologia representam uma forma de proporcionar assistência de qualidade de vida para recém-nascidos em fim de vida ou diante de doenças sem possibilidade de cura. Esta pesquisa tem como objetivo investigar a atuação da equipe multiprofissional nesse contexto, utilizando uma metodologia de revisão integrativa para explorar questões relevantes sobre os principais desafios e oportunidades. A literatura aponta para dificuldades na comunicação entre os membros da equipe, a predominância da abordagem curativa e a falta de preparo das equipes de saúde para lidar com a terminalidade. Apesar dos desafios apresentados, é evidente o potencial dos cuidados paliativos neonatais em oferecer terapias que promovam uma atenção integral e humanizada.
The effectiveness of the projects strategy in teaching the scientific research course in developing the skills of the twenty-first century among students of health sciences in Al-Mahwit Governorate
Authors: Al-Adwani Dr. Khaled Mutahar Hussein , Abbas Dr. Ahmed Abdel Qader , Al-Shaibani Muhammad Ali
Published: July 2024

The study aimed to discover effective strategies in the principles of scientific research in developing twenty-second century skills with health sciences students in Al Mahwit Governorate. The quasi-experimental model study with a group design was chosen to use and apply tribal methods. The study tool was the twenty-second century skills scale consisting of (9) main skills distributed over three sectors, so that the sample consisted of (74) female students confirmed to assist health scientists in the city of Al Mahwit, and the results of the subsequent study were reached:
1. There are statistically significant differences at the significance level (0.05) between the average number of students in the pre- and post-applications of the 21st Century Skills Scale according to each applied skill expression.
2. There are no statistically significant differences at the significance level (0.05) between the average number of students in the creative application of the Second Century Skills Scale only according to gender diversity and academic specialization.
Keywords: project strategy - scientific research - twenty-first century skills - health sciences.
Biomimicry in Science Classrooms: Learning Design Thinking Skills Inspired by Nature "A Proposed Teaching Model
Authors: Elbaz Prof. Marwa Mohamed
Published: July 2024

Biomimicry is one of the modern approaches that draw inspiration from natural models and processes for solutions to address human challenges, and it is also a new educational trend that has emerged to meet the needs of education, especially education for sustainability. The study aims to enrich the educational literature with qualitative additions about the applications of biomimicry in education, and to present a teaching model based on biomimicry to develop design skills among learners of science and interdisciplinary education. The study used a qualitative approach, specifically an integrative literature review methodology, to evaluate and analyze studies related to biomimicry and its impact on teaching and learning; With the aim of enhancing the theoretical and applied understanding of biomimicry in the context of education. The study provided a theoretical framework on: the concept of biomimetics, its levels and principles, how educational literature addressed the use of biomimicry in education and teaching, the relationship between biomimicry and design skills, and finally, it presented an effective framework for a teaching model using biomimicry that can be applied to develop design thinking skills. For learners across different educational stages.
Keywords:Biomimicry – Science Education- Interdisciplinary Education - Design Thinking - Education for Sustainability.
Effect of Teaching with Six-Dimensional Strategy in Mathematics to Developing Creative Thinking among Sixth Grade Students
Authors: AlAlyan Dr. Fatema
Published: July 2024

The research aimed to identify the effect of teaching with the six-dimensional strategy (PDEODE) in mathematics in developing creative thinking among a sample of sixth-grade students in the city of Damascus for the academic year (2022-2023 AD). The researcher used the quasi-experimental approach through an experimental design with two experimental and control groups, and tested Students on Torrance’s formal creative thinking scale in the two stages before and after the lessons. The sample of students in its final form consisted of (72) male and female students, who were divided into (36) male and female students for the control group who studied according to the followed teaching methods, and (36) male and female students for the experimental group who taught according to the dimensional strategy. Hexagram. After analyzing the results, it was found that there was a statistically significant difference between the scores of the answers of the students of the experimental and control groups on the post-application of the creative thinking scale, and the presence of a different effect size according to its components (fluency, originality, flexibility, and details), which indicates the positive impact of teaching according to the six-dimensional strategy in developing creative thinking. The researcher recommended using the six-dimensional strategy in the basic education stage in various academic subjects, introducing the strategy into teachers’ manuals, and suggested conducting studies on the six-dimensional strategy and building a measure of creative thinking.
Keywords: Basic learning, Constructivist Teaching, Fluency, Flexibility, Authenticity, Detail.
Development of SMART tourism: international and regional aspects
Authors: Dobrianska Natalia , Sarkisian Anna , Liganenko Margaryta , Orlova Natalia
Published: July 2024

Information technology is used in all spheres of life, rendering it indispensable to human activities. In present times, SMART technologies have become a routine reality, aiding in processing large volumes of information, enhancing work efficiency, improving people's lives, and protecting the environment. Unfortunately, Ukraine lags significantly behind technologically advanced countries in the use of innovative technologies in all sectors of the economy, including tourism. Despite its favorable geographical location, mild climate, significant recreational and healing resources, many historical landmarks, and natural sites, Ukraine has yet to unlock its full potential in the tourism industry. Implementing intelligent technologies presents new opportunities to expand Ukraine's tourism industry and the influx of travelers seeking a memorable experience. Consequently, further research in the technological field and the development and integration of cutting-edge technologies throughout various economic sectors is necessary to analyze results. The article analyzes intelligent technologies in developed countries and Ukrainian cities that have already implemented such technologies. Based on research findings, recommendations are made for deploying innovative technologies in the tourism sector of Ukrainian cities with notable tourism potential. The main objective of this research is to analyze the implementation of SMART technologies in daily life to restore Ukraine's economy and competitiveness of the tourism industry in the post-war period and enhance the environmental situation and safe surroundings while offering greater convenience to citizens. Adopting SMART technologies will uplift Ukraine's tourism industry to a superior level and facilitate competition with advanced countries.
Keywords: SMART tourism, information technologies, tourism, tourism industry, SMART technologies, innovations.
Modernity, Technology, and Copying
Authors: Huang Chiung-Ying
Published: July 2024

The evolution of modernity is closely linked to technological advancements, which encompass the duplication of sounds, the reproduction of images, and the copying of messages. This paper investigates various perspectives on the emergence of modern technologies, particularly focusing on their inherent aspect of “copying.” Here, “copying” is a broad term that includes reproducing disembodied voices and images, as well as duplicating artwork and communication materials. It explores how different writers react to the concept of “copying” within the technological landscape. While some, like Filippo Tommaso Marinetti and Rudyard Kipling, celebrate the public excitement and enjoyment associated with new communication technologies, others, including Henry James and Herman Melville, illustrate individuals ensnared in the realm of “copying,” where the pervasive gaze of overseers intrudes into the private realm of message transmission. This paper addresses the question of the relationship between copying and modernity, highlighting how a culture of “copying” enhances human capabilities while simultaneously generating issues such as misinterpretation, commodification, and detachment from natural order, ultimately raising concerns about identity, integrity, and security.
Optimizing electronic health records to support artificial intelligence
Authors: Hovenga Evelyn J. S. , Atalag Koray
Published: July 2024

Electronic health records (EHRs) provide the most important data sources for artificial intelligence (AI). Gaining access to quality data suitable for advanced analytics continues to be challenging. This rapid review documents the current state of available data; identifies foundational AI data/information needs; and explores the benefits of adopting new and emerging technologies to design and implement next-generation EHRs. Opportunities to optimize EHRs for AI purposes are identified. This review was informed by expert knowledge and shared experiences supported by the literature, including technical standards. Main findings include poor ecosystem-wide infrastructures due to the lack of adopting the right set of standards, and current data and knowledge governance no longer fit for purpose. While many jurisdictions are continuing the use of legacy systems, some forward-looking national health systems and health-care facilities are adopting transformational strategies by adopting a strong data and digital focus to transition to new-generation systems. New foundational-level national infrastructures with strong leadership and governance are essential to enhance the governance and quality of available data, from collection at source throughout the entire data supply chain. Secure and ubiquitous access to high-quality EHR data at scale will foster the evolution of more intelligent and trustworthy AI. Key characteristics of next-generation EHRs supported by currently available technologies and standards that are able to meet digital era demands are provided in this paper. We conclude that the use of generative AI in clinical settings can only be reliably achieved when EHRs are optimized throughout the entire global digital health ecosystem.
Integrated sources model: A new space-learning model for heterogeneous multi-view data reduction, visualization, and clustering
Authors: Fogel Paul , Geissler Christophe , Augé Franck , Boldina Galina , Luta George
Published: July 2024

In machine learning, multi-view data involve multiple distinct sets of attributes (“views”) for a common set of observations; when each view has the same attributes considered in different contexts, the data are said to contain multiple views of homogeneous format, which can be conceptualized as a tensor. In this article, we describe a novel approach for integrating multiple views of heterogeneous format into a common latent space using a workflow that involves non-negative matrix and tensor factorization (NMF/NTF). This approach, which we refer to as the integrated sources model (ISM), consists of two main steps: Embedding and analysis. In the embedding step, the views are transformed into matrices with common non-negative components. In the analysis step, the transformed views are combined into a tensor and decomposed using NTF. We also present a variant of ISM; the integrated latent sources model (ILSM), which offers significant advantages over ISM in terms of computational power and in cases where the views are highly unbalanced with regard to the number of attributes per view. Noteworthy, ISM can be extended to process multi-omic and multi-view datasets even in the presence of missing views. We provide a proof-of-concept analysis using five examples, including the UCI Digits (the University of California Irvine Pen-Based Recognition of Handwritten Digits) dataset, a public cell-type gene signatures dataset, and a multi-omic single-cell dataset. These examples demonstrate that, in most cases, multi-view clustering is better achieved with ISM or its variant ILSM than with other latent space approaches. We also show how the non-negativity and sparsity of the ISM model components enable straightforward interpretations, in contrast to other approaches that involve latent factors of mixed signs. Finally, we present potential applications to single-cell multi-omics and spatial mapping, including spatial imaging, spatial transcriptomics, and computational biology, which are currently under evaluation. ISM relies on state-of-the-art algorithms invoked through a simple workflow implemented in Python.
In situ bioprinting: Tailored printing strategies for regenerative medicine
Authors: Hu Chengwei , Wang Chenmin , Bian Shaoquan , Qi Weichen , Liu Bo , Wang Liangliang , Wen Chunyi , Wu Jun , W. Lu William , Zhao Xiaoli
Published: July 2024

 In recent years, three-dimensional (3D) bioprinting has emerged as a revolutionary biological manufacturing technology. Despite significant progress, current bioprinting technologies face critical barriers, such as the need for in vitro maturation of printed tissues before implantation and challenges of prefabricated structures not matching the defect shapes. In situ bioprinting has been introduced to address these challenges by printing customized structures to the wound shape via direct deposition of biological inks at the tissue interface. This paper reviews strategies to optimize printing performance for enhanced tissue repair and analyzes the advantages, challenges, and future directions of in situ bioprinting technologies.
Double-protein-loaded 3D-printed polyetheretherketone cage for promoting interbody fusion via osteogenic differentiation
Authors: Zheng Feng , Gao Xiaoqiang , Chai Sheng , Lin Haibin , Liu Huan
Published: July 2024

Intervertebral disc degeneration (IDD) is a common condition characterized by age-related wear and tear of the spine. In advanced stages or severe cases of IDD, surgical treatment involving the implantation of an interbody cage is often the primary treatment approach. Polyetheretherketone (PEEK) has been widely used in orthopedic and spinal implants due to its remarkable mechanical properties, biocompatibility, and corrosion resistance. However, when used in interbody cages, PEEK exhibits poor processability and biological inertness, which are significant disadvantages that need to be addressed. In this work, we first fabricated the PEEK cage via the fused deposition modeling (FDM) method. To improve its fusion effect, bone morphogenetic protein 2 (BMP2) was loaded onto sulfonated PEEK and sealed with gelatin/chitosan (Gel/Chi) multilayer films. Substance P was then grafted on the surface with a Schiff base. When the cage is implanted, substance P is released first, recruiting bone marrow-mesenchymal stem cells (MSCs) to the implant surface. Subsequently, upon degradation of the Gel/Chi multilayer films, BMP2 is slowly released and promotes osteogenic differentiation of MSCs. In vivo results revealed that the double-protein-loaded PEEK cage exhibited remarkable fusion effects. This work provides a novel approach for the design and fabrication of a PEEK intervertebral fusion device with an excellent fusion effect.
Direct ink writing of biomimetic hydroxyapatite scaffolds with tailored concave porosity
Authors: del-Mazo-Barbara Laura , Diez-Escudero Anna , Lodoso-Torrecilla Irene , Aramesh Morteza , Persson Cecilia , Ginebra Maria-Pau
Published: July 2024

Direct ink writing is a promising technology for the fabrication of personalized bone grafts, as it enables the customization of their geometrical conformation with high reproducibility and is compatible with the use of self-setting calcium deficient hydroxyapatite inks. However, the scaffolds obtained by DIW consist mostly of convex filaments, which is a limitation since concave surfaces have been shown to promote bone regeneration in vivo. In this work, we explore the use of triply periodic minimal surface (TPMS) designs in DIW of calcium phosphate self-hardening inks as a strategy to obtain scaffolds with controlled concave macropores. The limitations of the printing parameters with high ceramic loaded inks used in DIW enabled achieving only 20% nominal porosities of Gyroid-, Diamond- and Schwarz-based structures. The inherent layered pores from TPMS geometries allowed obtaining concavities typically unattainable via DIW, bearing substantial implications for subsequent osteoinductive capabilities. Although the mechanical properties were lower in the TPMS-based scaffolds than in the orthogonal patterned ones, the blood permeability of the TPMS-based structures was higher. The concave pore architecture enhanced the osteogenic potential of the biomimetic ceramic, increasing SaOs-2 cell adhesion, proliferation, differentiation and mineralisation.  
Navigating GDPR Compliance: The Intersection of Data Governance, Accountability, and Organizational Culture
Authors: - Navdeep Singh , - Shallu Bishnoi
Published: July 2024

This Abstract highlights the GDPR's important role in shaping data protection practices within the EU and its broader implications for data governance. The GDPR harmonizes data protection laws across EU, establishing comprehensive guidelines for the collection, processing, storage, and transfer of personal data. The GDPR directs significant penalties for non-compliance, thereby reinforcing the importance of adhering to data protection standards. Additionally the GDPR also validates the principles of lawfulness, fairness, transparency, and accountability in the processing of personal data.
ADAPTIVE MODULATION AND CODING (AMC) PADA MOBILE WiMAX MIMO-OFDM
Authors: Pinardi Sofia , Ariman Ariman , Hadi Veriah
Published: July 2024

Akses komunikasi wireless yang cepat, fleksibel dan reliable sangat dibutuhkan untuk mendukung teknologi informasi dan multimedia yang semakin berkembang. Salah satu inovasi untuk memenuhi hal tersebut adalah teknologi mobile WIMAX. Tetapi kondisi kanal pada komunikasi wireless yang selalu berubah-ubah sangat terpengaruh terhadap performansi sistem jika tidak digunakan modulasi dan coding yang tepat, yang paling sesuai dengan kondisikanal. Adaptive Modulation and Coding (AMC) pada mobile WIMAX dapat meningkatkan kapasitas kanal dengan caramenekan nilai BER yang terjadi pada data yang dikirimkan sehingga dapat meningkatkan performansi sistem
RANCANG BANGUN MESIN CNC MINI UNTUK MENGAMBAR BERBASIS MIKROKONTROLER ARDUINO MEGA 2560
Authors: Mukminin Akirul , Effendi Harlan
Published: July 2024

Mesin CNC mini adalah sebuah alat CNC yang digunakan untuk menggambar dengan menggunakan softwer otomatis. Alat ini dioperasikan oleh sebuah komputer, oleh sebab itu alat ini disebut CNC mini (Computer Numerical Control) yang berarti "komputer kontrol numerik". Alat ini menggunakan mikrokontroler Arduino Mega 2560 sebagai pemroses data yang di berikan oleh komputer. Bagian mekanik di rancang mempergunakan CDRom. CDRom dari sebuah PC komputer yang dirancang sedemikian rupa guna menjadi suatu alat yang dapat digunakan sebagai alat menggambar otomatis . Dua buah motor stepper digunakan sebagai X dan Y axis, dan1 buah motor servo digunakan sebagai Z axis. Motor-motor tersebut memerlukan driver agar outpu dari arduino dapat disinkronkan dengan motor-motor yang digunakan. Driver yang dimaksud adalah Sheild Driver Motor L293D driver ini berfungsi sebagai penerima data dari arduino dan kemudian di hubungkan ke motor stepper dan motor servo. Pada bagian software menggunakan software inscape untuk mengubah gambar ke ekstensi G-Code, software processing 3 sebagai pengubah gambar ke dalam coding dan mentransfer coding tersebut ke arduino, dan software arduino Ide digunakan untuk membuat coding yang kemudian dumasukan ke dalam Ic arduino mega 2560.
PENDETEKSIAN DINI TERHADAP ARUS BOCOR KABEL TANAH TEGANGAN MENENGAH PADA TRANSFORMATOR 150/20kV
Authors: Sofwan Agus , Kusuma S.Angga
Published: July 2024

Didasari atas peristiwa pada Januari 2017 yang telah terjadi gangguan trip PMT 150 kV dan 20 kVtransformator 4 di GI Jatirangon. Pada gangguan tersebut sistem proteksi yang bekerja yaitu rele differentialfasa T dan REF 20 kV. Dampak dari gangguan mengakibatkan padamnya beban sebesar 1350 A, 35 MW dan 5Mvar. Penyebab gangguan yaitu terjadinya breakdown pada kabel tanah 20 kV fasa T core 1. Hal inimengakibatkan terjadinya hubung singkat ke tanah sehingga rele proteksi differential dan REF 20 kV bekerjadikarenakan rele tersebut merasakan adanya gangguan di daerah pengamannya.Hasil penelitian ini berupaperancangan suatu alat monitor pendeteksian dini. Alat ini digunakan untuk mengetahui besarnya arus bocorpada kabel tanah agar dapat meminimalisir terjadinya gangguan yang menyebabkan terjadinya pemadamanaliran daya listrik. Hasil monitor arus bocor pada kabel tanah fasa T core 1 didapatkan arus sebesar 0,6 Adengan suhu 35 oC. Dengan metode perhitungan kegagalan thermal untuk arus bocor didapatkan hasil sebesar0,56180 A dengan suhu 35 oC. Perbandingan antara perhitungan dengan pengukuran arus bocor pada kabeltanah fasa T core 1 diperoleh sebesar 6,36 %.Kata kunci : Transformator, Kabel Tanah 20 kV, Arus Bocor, Alat Monitor, Deteksi Dini
RANCANG BANGUN DAN IMPLEMENTASI ANTENA YAGI UDA UNTUK KOMUNIKASI JARINGAN WLAN
Authors: Octaviani Fanti , Abrianto Heru
Published: July 2024

Antena yagi dulunya dikenal hanya digunakan sebagai antena penerima untuk siaran TV atau radio, kini dapat di aplikasikan untuk perangkat pemancar dan penerima WLAN. Antena yagi untuk WLAN saat ini hanya menggunakan satu frekuensi yaitu hanya dapat digunakan pada frekuensi 2.4 GHz. Sedangkan untuk saat ini frekuensi WLAN tidak hanya 2.4 GHz saja, namun juga sudah ada yang menggunakan WLAN pada frekuensi 5.8 GHz. Antena yagi ini memiliki gain yang bervariasi, selain itu gain yang digunakan relative besar berkisar 3-20 dB. Besar gain pada antena yagi ini dipengaruhi oleh banyaknya director. Untuk perancangan antena yagi menggunakan 12 element yang terdiri dari reflector, driven, dan director. Pada saat pengujian nilai VSWR yang didapat 1.111 untuk frekuensi 2.4 GHz dan untuk frekuensi 5.8 GHz yaitu 1.598. Untuk nilai Return Loss yang didapat yaitu -25.522 dB pada 2.4 GHz dan -12.750 dB pada frekuensi 5.8 GHz. Lalu untuk nilai impedansi pada 2.4 GHz yaitu 46.426  dan untuk 5.8 GHz adalah 49.819 . Untuk gain yang didapat  10 dB yaitu 22,39 dB untuk frekuensi 2.4 GHz dan 22,77 dB untuk frekuensi 5.8 GHz.
RANCANG BANGUN SISTEM MANAJEMEN KUNCI PADA PERKANTORAN
Authors: Rahmi Wildatur , Ahmad Arfian
Published: July 2024

Pada sebuah kantor terdapat beberapa bagian atau unit. Setiap unit dikepalai oleh seorang kepala bagian yang bertanggung-jawab terhadap unit yang menjadi tanggung-jawabnya, seperti: ruang kantor, pergudangan, ruang dokumen, ruang peralatan, dll. Sistem manajemen kunci pada perkantoran adalah suatu sistem yang mengatur dan mendata penggunnan kunci pada setiap bagian pada sebuah kantor. Dalam rangka mengontrol penggunaan kunci, dirancang-bangunlah suatu sistem manajemen kunci. Rancang-bangun sistem ini menggunakan modul arduino mega 2560 sebagai pusat kontrol, disamping sensor proximity, keypad, modul RFID RC522 dan solenoid. Disamping itu, sistem kontrol juga menggunakan perangkat lunak Borland Delphi 7 untuk menampilkan data dari pengguna kunci. Dari hasil pengamatan, sistem manajemen kunci berfungsi dengan baik dimana setiap pimpinan unit hanya dapat mengambil kunci yang menjadi tanggung-jawabnya.
RANCANG BANGUN ALARM PENDETEKSI KEBAKARAN PADA GEDUNG BERTINGKAT MENGGUNAKAN METODE LOGIKA FUZZY BERBASIS MIKROKONTROLLER SERTA TERINTEGRASI IOT
Authors: Supriyadi Edy , Subagja Faizal Puji
Published: July 2024

Seperti diketahui kebakaran merupakan hal yang sangat merugikan, khususnya bagi manusia. Begitu banyak penyebab dan dampak yang diakibatkan oleh kebakaran yang terjadi, mulai dari kehilangan harta benda bahkan nyawa. Ketika terjadi kebakaran terkadang pemadam kebakaran terlambat datang ke lokasi terjadinya kebakaran dikarenakan beberapa faktor. Tujuan dari penelitian ini adalah sebagai tindakan pertama untuk meminimalir penyebaran titik api kebakaran, disaat ketika pemadam kebakaran belum sampai menuju lokasi terjadinya kebakaran dan memberikan pemberitahuan secara real time menuju departemen pemadam kebakaran Via IoT. Sistem ini bekerja menggunakan metode logika fuzzy untuk mengukur kondisi asap dan suhu ruangan, dimana output dari proses logika fuzzy tersebut adalah kecepatan putaran kipas exhaust. Serta sensor api akan mendeteksi api pada ruangan jika terdeteksi api, pompa akan aktif untuk memadamkan api pada ruangan tersebut serta secara bersamaan akan mengirimkan data dan status kebakaran menuju webserver. Berdasarkan hasil pengujian sistem ini, waktu pengiriman data dari mikrokontroller menuju webserver memerlukan waktu kurang lebih selama 2 detik
PENGEMBANGAN MODUL REDUNDANSI PESAWAT UPS BERBASIS MIKROKONTROLER
Authors: Alimsyah Surya , Robbi Amin Muhammad
Published: July 2024

Modul redundansi adalah alat yang mengoperasikan satu dari dua buah UPS (Uninterrupt power supply) secara bergiliran. Otomatisasi pengalihan terjadi ketika UPS yang menyuplay tegangan ke load bermasalah. Makalah ini mengembangkan modul redudansi yang sudah ada menjadi alat berbasis mikrokontroler, dengan keypad dan display LCD sebagai antar muka penyetingan. Sensor sensor yang terdiri dari 'detektor tegangan DC', 'pengindra arus beban', dan' pengindra tegangan AC', serta rekam data berbasis WinCC. Hasil prototype yang dibuat telah teruji, dan berfungsi dengan baik dalam mempermudah kepastian setting nilai batas bawah dengan tingkat kepastian mencapai 0,1V. Pada skala penuh tingkat akurasi sensor dan detektor cukup relevan dengan nilai sebesar 99,15 % untuk 'detektor tegangan DC', 99% untuk 'pengindra arus', dan 99,1% untuk 'pegindra tegangan AC'. Otomatisasi penggiliran berfungsi dengan baik disertai dengan keberimbangan, sehingga waktu operasi antar UPS menjadi lebih setara. Sistem rekam data untuk merekam 'pengindra arus', 'pegindra tegangan AC' serta sensor yang telah ada pada UPS yaitu AC fail, Rectifier fail, overvoltage, dan low voltage, berfungsi dengan baik. Selain dapat ditampilkan dalam grafik realtime, data yang direkam dapat dimunculkan kembali dalam durasi waktu yang dapat diatur.
ALAT PENGUKUR PANJANG PIPA PADA PEKERJAAN SUMUR MINYAK DAN GAS BERBASIS MIKROKONTROLER
Authors: Alimsyah Surya , Davin Davin
Published: July 2024

Coiled tubing adalah suatu alat yang digunakan pada beberapa jenis perkerjaan di sumur minyak dan gas. Fungsi dari coiled tubing ini adalah untuk mengantarkan alat mekanikal, sensor, atau cairan kimia ke dalam sumur. Berdasarkan fungsinya, parameter kedalaman dan kecepatan menjadi penting untuk diketahui dalam proses pekerjaannya. Pada umumnya banyak perusahaan yang masih menggunakan depth counter secara konvensional (tidak otomatis). Walaupun ada beberapa perusahaan yang sudah menggunakan depth counter digital. Tetapi depth counter digital tersebut hanya bisa membaca kecepatan dan kedalaman, tidak dilengkapi dengan sistem peringatan kecepatan, dan kedalaman disaat mencapai target. Makalah ini merancang dan membuat depth counter digital yang akan mengatasi kelemahan depth counter konvensional dalam hal kemudahan kalibrasi, pergantian satuan ukur, pengukuran kecepatan / kedalaman secara real time, dan perekaman data pekerjaan secara otomatis. Selain itu depth counter ini juga dilengkapi dengan sistem alarm. Alarm ini berfungsi untuk memberitahukan kepada operator disaat terjadi perubahan kecepatan diluar batas yang diperbolehkan, serta alarm disaat ujung coiled tubing sudah mendekati target kedalaman, dan alarm ketika coiled tubing mencapai target.
RANCANG BANGUN KONVEYOR PENGIRIM MAKANAN PADA RESTORAN BERBASIS MIKROKONTROLER MENGGUNAKAN METODE PWM
Authors: Muis Abdul
Published: July 2024

Di dalam restoran cepat saji sering dilihat orang-orang yang berlalu lalang, entah itu dari pelayan ataupun para pengujung, bahkan terkadang ketika pelayan sedang mengantar makanan tanpa sengaja makanan terjatuh akibat tertabrak orang lain. Untuk itu dalam makalah ini dibuat konveyor pengirim makanan dengan tujuan mengurangi kesalahan kerja, dimana didalam restoran tersebut terdapat 4 buah meja yang sudah dilengkapi dengan tombol push button yang berfungsi sebagai tombol input dari meja pemesan untuk memesan makanan. Sistem alat ini menggunakan mikrokontroler ATmega 2560 dan beserta komponen-komponen pendukung lainnya seperti keypad, sensor infrared, LCD, LED, buzzer, motor DC. Dimana semua komponen pendukung tersebut dikontrol oleh mikrokontroler ATmega 2560. Sistem pengendalian konveyor pengirim makanan ini menggunakan sistem kendali PWM. Prinsip kerja dari sistem ini berdasarkan jenis makanan yang di pesan oleh konsumen, diproses oleh mikrokontroler dan diberi nilai PWM yang telah ditentukan. Sistem kendali PWM digunakan untuk mengatur putaran motor DC agar semakin banyak jumlah pesanan makanan basah yang dipesan oleh konsumen maka semakin kecil nilai PWM yang diberikan.
Influence of Principals’ Participative Leadership Style on Tutors’ Support for Implementation of Performance Appraisal in Public Primary Teachers Training Colleges in Kenya
Authors: Kavita Mwania Johnson , Kalai Jeremiah Mutuku , Okoth Ursulla Achieng
Published: July 2024

The study aimed at investigating the influence of principals’ participative leadership style on tutors’ implementation of the performance appraisal in teachers training colleges in Kenya. The study sought to test the following null hypothesis H01: There is no significant relationship between Principals’ participative leadership style and tutors’ support for the implementation of the performance appraisal in public primary teachers training colleges in Kenya. The study was guided by the Path-Goal Theory. The study employed a descriptive research design. The study's target population comprised 840 tutors and 21 principals in the 21 public teacher training colleges in Kenya in 2021. The sample size was determined using Yamane's formula. Therefore, the sample size for tutors was 271. Stratified random sampling was used to select tutors in teachers’ training colleges in Kenya. A census was used to select all the 21 principals of training colleges in Kenya. Primary data were collected using a questionnaire for tutors and an interview guide for the 21 Principals. It was established that principals’ participative leadership style had a positive significant (β=.431, p=0.00<0.05) relationship with the implementation of performance appraisal of tutors. The study concluded that principals’ participative leadership style had a significant influence on tutors’ implementation of performance appraisal. Based on the study's findings, it is recommended that the Ministry of Education, Board of Management, Kenya Education Management Institute, teacher training colleges, universities, parents, and Quality Assurance and Standards officers collaborate in designing and implementing performance appraisal systems. This inclusive approach ensures diverse perspectives are considered, leading to a comprehensive and effective appraisal system aligned with the sector's needs
TANTANGAN KETERAMPILAN GERAK ANAK DI TENGAH MARAKNYA GAME ONLINE: TINJAUAN SISTEMATIS
Authors: Ramadan Gilang
Published: July 2024

Penelitian ini mengkaji tantangan Keterampilan Gerak Dasar (KGD) anak-anak di Indonesia di tengah meningkatnya penggunaan game online. Latar belakang penelitian ini menunjukkan bahwa permainan online yang berlebihan dikaitkan dengan penurunan aktivitas fisik, perilaku sedentari, serta masalah kesehatan seperti obesitas dan hipertensi. Tujuan penelitian ini adalah untuk mengevaluasi pengaruh game online terhadap KGD anak-anak dan pentingnya intervensi yang terstruktur untuk meningkatkan keterampilan motorik mereka. Metode penelitian melibatkan tinjauan sistematis terhadap literatur yang mencakup artikel dari jurnal nasional dan internasional dengan menggunakan kata kunci 'fundamental movement skills' dan 'online games'. Dari 140 publikasi awal, hanya 10 artikel yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan bahwa meskipun game online dapat mengurangi aktivitas fisik dan menghambat perkembangan KGD, intervensi fisik terstruktur terbukti meningkatkan keterampilan motorik anak-anak. Kesimpulan penelitian ini menekankan perlunya pendekatan multifaset yang melibatkan orang tua dan guru dalam mempromosikan aktivitas fisik dan menciptakan lingkungan yang mendukung untuk mengatasi dampak negatif game online dan mendorong gaya hidup aktif di kalangan anak-anak Indonesia.