bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploration of Concordance Behavior between Tuberculosis Patients, Families, and Healthcare Workers in Supporting Treatment Adherence: A Qualitative Study
Authors: Permana Roni , Afrizal . , Yunus Faisal , Bachtiar Adang
Published: February 2025

Background

Indonesia continues to face a significant problem with Tuberculosis (TB), ranking as the country with the second highest global burden. Concordance behavior is crucial to treatment adherence. However, understanding of concordance behavior determinants remains incomplete.

Objective

This study aims to explore the understanding and experience of TB patients, their families, and health workers regarding communication in support of TB treatment concordance.

Methods

We employed a phenomenological design to explore the lived experiences of individuals involved in TB treatment. Semi-structured interviews were conducted with a purposive sample of TB patients, family members, and healthcare workers at primary healthcare centers in Padang City, Indonesia. We utilized the Braun and Clarke approach-guided thematic analysis to identify salient themes emerging from the interview data.

Results

Data analysis yielded four principal themes: understanding of concordance, the role of the family in treatment communication, communication barriers, and effective communication strategies to support the concordance. Many patients and relatives were unsure about TB treatment. Family pressure on medication adherence was significant, yet it sometimes caused patient stress. Healthcare workers' time and TB stigma hindered communication. Brochures, films, and digital media have improved knowledge and adherence.

Conclusion

Concordance behavior among patients, families, and healthcare workers is essential. Enhancing adherence necessitates ongoing education, family engagement, and reduction of stigma for TB treatment.
In Silico Prediction of Non- synonymous SNPs in the Human CALCR Gene
Authors: Sivakumar Kaniha , Sidhic Nihala , Subbiah Usha
Published: February 2025

Background:

The Calcitonin receptor (CALCR) gene encodes a protein essential
for bone metabolism, playing a key role in inhibiting bone resorption and promoting
renal calcium excretion. Polymorphisms in CALCR have been associated with differences
in bone mineral density, osteoporosis, and an increased risk of calcium stone urolithiasis.

Aim:

This study aimed to investigate the non-synonymous SNPs of human genes.

Objective:

This study was conducted to analyse the structural and functional impact of
high-risk non-synonymous single nucleotide polymorphisms (nsSNPs) in the CALCR
gene using bioinformatics tools.

Methods:

We retrieved nsSNPs from the NCBI and Uniprot databases and assessed their
deleterious potential using SIFT, PolyPhen v2, PROVEAN, PANTHER, PhD-SNP, and
SNPs and GO. Gene-gene interactions were examined with GeneMANIA, while proteinprotein
interactions were analyzed via STRING. Structural and functional predictions
were performed using I-Mutant, MUPro, ConSurf, SOPMA, NetSurf 2.0, AlphaFold, and
NetPhos 3.1.

Results:

Our analysis found 17 deleterious nsSNPs (rs972946, rs138829125,
rs146344939, rs148707949, rs149570603, rs149628324, rs200643258, rs200900623,
rs201985045, rs267601640, rs368981699, rs369253212, rs369926913, rs371453754,
rs374929068, rs375143115, rs375417465) that destabilize the CALCR protein. ConSurf
revealed that 9 of these high-risk nsSNPs are located in conserved regions, with the variants
S129Y, R321Q, D101Y, D77V, L176F, P122S, N312S, M187T, and W406R being
identified as highly conserved. NetsurfP-2.0 analysis indicated that some nsSNPs are exposed
while others are buried, and phosphorylation analysis highlighted variations in
threonine and tyrosine residues.

Conclusion:

These findings indicate that the identified nsSNPs may substantially affect
the functionality of CALCR and could potentially be used as biomarkers for disease diagnosis
and targets for therapy.
An Overview of the Phytochemical Pharmacology and Potential Biomaterials of Curcuma aeruginosa Roxb. against COVID-19
Authors: Allaq Abdulmutalib Alabeed , Aziz Aziyah Abdul , Salim Fatimah , Sidik Norrizah Jaafar
Published: February 2025

Natural materials are gaining popularity in pharmaceuticals and food applications,
and they have the potential to alleviate the significant environmental problems
generated via traditional materials. The Curcuma genus, particularly Curcuma
aeruginosa Roxb., is expanding due to its prominence in culinary and traditional medicinal
sectors. Curcuma species are esteemed for their rich nutritional value and the
discovery of new bioactive compounds exhibiting antioxidative, antimicrobial, antiinflammatory,
and anticancer actions. This study offers a meticulous examination of
the traditional uses, ethnopharmacology, phytochemistry, and pharmacological attributes
of C. aeruginosa (Roxb.). We also delve into the species' bioavailability and
health benefits by emphasising the nutritional composition, bioactive components,
and biological properties. Given the sparse existing data, this review sought to spotlight
the potential of the substances present in this species in functional foods and
pharmaceutical arenas. Distinguished by its red flower lobes, greenish-blue rhizome,
and other notable features, it has long been employed in traditional medicine for ailments
ranging from wounds to asthma, attributable to its disinfectant, expectorant,
and tonic properties. Advanced gas chromatography-mass spectrometry (GC-MS)
techniques have discerned various phytochemicals from the plant, leading to revelations
about its diverse pharmacological potentials, including antioxidative, antimicrobial,
anti-inflammatory, and anticancer activities. In the context of the COVID-19
pandemic, C. aeruginosa (Roxb.) has stood out as a promising botanical candidate,
with ten of its compounds, such as curcumenol and β-pinene, displaying notable efficacy
against COVID-19 antigens. Thus, while C. aeruginosa Roxb. has already proven
its worth in traditional oriental medicine, current findings underscore its potential
as a potent therapeutic resource, especially concerning COVID-19, and advocate for
intensified research into its pharmaceutical applications.
CAR-T Cell Therapy: Illuminating the Path to Solid Tumour Recovery
Authors: Karati Dipanjan , Sarkar Sinjini , Kundu Moumita , Majumder Pratyasha , Biswas Aishi , Mondal Tarishi , Bandyopadhyay Soumendra Nath , Mahanti Beduin , Mukherjee Swarupananda
Published: February 2025

The favourable results of Chimeric Antigen Receptor (CAR) T-cell therapy in the
management of hematologic malignancies have heightened the formerly unparalleled enthusiasm
for employing this novel strategy in the treatment of diverse types of human malignancies.
Although there has been a lot of study on increasing the effectiveness of these cells in solid tumors,
few studies have examined challenges and potential fixes. A number of the main challenges
that CAR T-cells face include confined trafficking and penetration into the tumour zone,
hypoxic and immunosuppressive tumour microenvironment (TME), antigen escape and heterogeneity,
CAR T-cell fatigue, and intense incurable toxicities. Beyond these constraints, CAR
designs must expand their applicability to a wider variety of malignancies by surpassing the
standard architectures. In order to overcome current obstacles and improve the efficacy and materiality
of this therapeutic manner, investigators are combining many medicinal approaches
with a broad range of engineering solutions.
Effectiveness of Anti-Gravity Treadmill Exercise After Total Knee Arthroplasty: Protocol for a Randomized Controlled Trial
Authors: Jääskeläinen Elina , Manninen Mikko , Hurri Heikki , Rantasalo Mikko , Zhou Yun , Kautiainen Hannu , Ristolainen Leena
Published: February 2025

Background

Postoperative rehabilitation following total knee arthroplasty (TKA) varies worldwide. In Finland, patients receive guidance on safe walking and home exercises from a physiotherapist both before and after TKA. These are performed independently after surgery. However, a sedentary lifestyle is rather common among patients who have undergone TKA, with pain often limiting postoperative walking, training, and activities of daily living.

Objective

This randomized controlled trial aimed to investigate the effectiveness of anti-gravity exercise, precisely the AlterG anti-gravity treadmill, on postoperative rehabilitation following TKA and to obtain new knowledge on this form of rehabilitation to better use it in the future.

Methods

This randomized controlled trial study divided the patients into two groups: the intervention group and the control group. The follow-up period was 12 months. Research data were collected through questionnaires and functional tests. All patients in both groups responded to the questionnaires and participated in functional tests before surgery as well as 4 and 12 months after surgery. Patients in the intervention group exercised on the AlterG treadmill 10 times after the surgery. All the patients in this study performed the exercises as instructed when they were in the hospital. The primary outcomes were perceived pain, walking ability, and quality of life.

Results

The data collection process began in 2018 and concluded in 2022, intending to obtain valuable information regarding the effect of AlterG training after TKA and determine whether it, along with traditional exercises, could be an effective form of rehabilitation that can be performed at home. We hypothesized that AlterG training would lead to faster rehabilitation, better walking quality, improved quality of life, improved physical activity, and improved overall functioning. The results of this study will be analyzed in 2025 and 2026.

Conclusions

This study provides information on how AlterG training can be used in rehabilitation after TKA, further enhancing the rehabilitation program for patients undergoing TKA in general.

Trial Registration

ClinicalTrials.gov NCT03904030; https://clinicaltrials.gov/study/NCT03904030

International Registered Report Identifier (IRRID)

DERR1-10.2196/59935
Efficacy, Feasibility, and Acceptability of an Emotional Competence Tele-Intervention for Mandarin-Speaking Children Aged 5 to 7 Years With Developmental Language Disorder: Pilot Study With an Interrupted Time-Series Design
Authors: Lu Hsin-Hui , Liang Shih-Yuan , Huang Yi-Chia
Published: February 2025

Background

Children with developmental language disorder (DLD) often experience language difficulties that hinder their ability to acquire emotional competence. Poor emotional competence is associated with emotional and behavioral problems in young children.

Objective

This research involved two studies focusing on (1) the emotional competence of Mandarin-speaking children aged 5 to 7 years with DLD and (2) the efficacy, feasibility, and acceptability of a tele-intervention designed to enhance their emotional competence in Taiwan.

Methods

Five children with DLD from study 1 declined to participate in study 2, the emotional competence tele-intervention, and were excluded from the analysis. We compared the emotional competence of 20 Mandarin-speaking children with DLD to that of 24 children with typical language development (TLD). The children with DLD were, on average, aged 5.79 (SD 0.47) years, whereas the children with TLD were, on average, aged 5.93 (SD 0.31) years. We assessed the children’s emotional competence, nonverbal ability, verbal comprehension, vocabulary acquisition, and expressive language skills. In study 2, all children with DLD included in study 1 engaged in an emotional competence tele-intervention. An interrupted time-series design was used to examine their emotional competence. In total, 20 children with DLD provided data on emotional competence evaluated using the Emotional Lexicon Test. These data were individually collected at 3 time points after study 1 (time 1). These phases included baseline (time 1 to time 2), during the tele-intervention (time 2 to time 3), and follow-up (time 3 to time 4), spanning approximately 18 to 20 weeks from time 1 to time 4. Recruitment, retention, and attendance rates were calculated to evaluate the intervention’s feasibility, and participant mood was evaluated after each session to calculate the intervention’s acceptability.

Results

No significant changes in the children’s ability to understand basic or complex emotional terms were observed during the baseline period. However, changes were observed during the tele-intervention period, and these changes remained throughout the follow-up period. With a recruitment rate of 80% (20/25), all participants completed 4 intervention sessions, with retention and attendance rates exceeding 95% (19/20). A total of 90% (18/20) of the participants deemed each session to be acceptable.

Conclusions

Mandarin-speaking children aged 5 to 7 years with DLD exhibited lower emotional competence compared with their counterparts with TLD. Tele-interventions are effective in enhancing the emotional competence of children with DLD, demonstrating feasibility and acceptability for these children and their parents in Taiwan.
The Role of the School Committee in Improving the Quality of Elementary Education at SDN 2 Cakranegara, SDN 14 Cakranegara, and SDN Tamping, Indonesia
Authors: Paramitha Baiq Devy , Sudirman Sudirman , Waluyo Untung , Mustari Mohamad , Fahruddin Fahruddin
Published: February 2025

This study aims to determine relevant aspects for understanding and developing the role of the school committee in improving the quality of basic education at Cakranegara 2 Public School, Cakranegara 14 Public Elementary School and Tamping Public Elementary School, with sub-focuses including the role of school committees in improving the quality of basic education, factors that influence the effectiveness of school committees, good practices involving school committees in improving the quality of education, and the interaction of school committees to achieve set goals. This study uses a qualitative descriptive approach with a case study type. Data were collected using interviews, observation, and documentation methods using primary and secondary data sources. Data analysis techniques use an interactive model of data collection, condensation, presentation, and conclusion. At the same time, the validity of the data will be examined using the triangulation of sources and methods used. The research findings show that the school committee is important in decision-making, supervision, and fundraising to support educational activities. However, the effectiveness of the school committee is influenced by factors such as the level of parental involvement, support from the school, and communication between the school committee and stakeholders at other levels. This study also found that best practices involving school committees can significantly improve the quality of basic education in the schools studied.
Evaluating The Economic Impact Of Tax Avoidance And Evasion On Personal Income Tax Administration
Authors: Yusuff Taofiq Olasunkanmi , Ogieriakhi Princess Abies , Olusola Gabriel Oladapo , Ibegbulem Paschal Chigozie , Adewumi John Oluwademilade , Esegine Jennifer Kesiena , Aderibigbe Tope Adetola , Uchechukwu Emmanuel Ohaeri
Published: February 2025

This study investigates the effects of tax avoidance and evasion on personal income tax administration, focusing on their impact on revenue generation, administrative efficiency, and compliance. Data were collected from 175 Federal Inland Revenue Service (FIRS) employees in Osun State using a survey design. Key findings revealed a significant positive correlation (r=0.506, p<0.05) between tax avoidance, evasion, and the challenges faced in tax administration. Regression analysis showed that 57.7% of the variability in personal income tax administration is explained by these practices (R² =0.577, F=118.76, p<0.05), emphasising that high tax rates encourage avoidance and evasion (B= 0.65, p<0.05). The study concludes that balanced tax policies, improved enforcement mechanisms, and taxpayer education are essential to curbing non-compliance and enhancing administrative efficiency.
IoT based Water Quality Monitoring System
Authors: Manwatkar Rushabh
Published: February 2025

The growing demand for clean, consumable water is becoming increasingly critical, especially in rural areas, due
to government inefficiencies and rising populations. This project addresses the issue by providing real-time monitoring of
water’s physicochemical quality in a more cost-effective way than traditional laboratory-based sampling methods. It utilizes a
wireless, multi-sensor network to assess factors like electrical conductivity, total dissolved solids (TDS), turbidity, and water
temperature. Designed for use in bodies of water like lakes, rivers, and reservoirs, where water quality varies by location, the
system includes a boat that can move across the water, controlled remotely by the user. Its hull shape reduces water resistance
and enhances stability. The boat is equipped with a radio frequency module for wireless communication. Data, including
impurity levels and hazard alerts, are displayed through a graphical user interface (GUI). Tests conducted on various water
sources confirm the system’s effectiveness in detecting and displaying these parameters in real-time.
Formulation and Evaluation of Herbal Shampoo
Authors: Jatar Siddhesh
Published: February 2025

The aim of this research is to create and assess a multi-herbal shampoo using herbal components. Aloe powder, Reetha
powder, Shikakai powder, Hibiscus flower, and Alma powder Citric acid was used to adjust the pH and a little amount of methyl
paraben was added as a preservative. This study’s primary goal is to make and assess a herbal shampoo and identify its
physiochemical function, with a focus on the product’s efficacy, safety, and quality. Herbal shampoo is a natural hair care
product that is used to strengthen, darken, and remove dandruff and grease from hair. Additionally, it gives the hair shine, softness,
and smoothness. Shampoo is a pre- mixture of cosmetics that uses a variety of medications. these medications have a variety of
adverse effects, including headaches, nausea, high scaling, hair loss, and discomfort from scratching. In order to create herbal
shampoo without any negative effects, an experiment is conducted. The most popular hairtreatment isshampooing. Shampoos are
mostly products designed to clean the scalp and hair. Despite being safer and more effective than synthetic shampoos, it appears
unlikely that herbal shampoos will be well-liked by customers in the current market. A more drastic strategy for making herbal
shampoo more widely used would be to alter consumer expectations by emphasizing efficacy and safety. We have evaluated and
compared the herbal shampoo created in a previous study with two commercially available shampoos. The results of this study
show that consumers have occasionally experienced negative side effects as a result of synthetic preservatives.
Power Reduction in Advanced Technology Nodes Using Multi-Bit Flip-Flops and Banking Techniques in Physical Design
Authors: Murali Selva Lakshman
Published: February 2025

As technology advances into sub-10nm nodes, power consumption remains one of the most challenging constraints in
VLSI (Very Large Scale Integration) designs. In this paper, we explore how multi-bit flip-flops (MBFFs) and multi-bit banking
techniques can be used effectively to achieve significant power reduction while maintaining high performance and low area
overhead. Through extensive simulation results and design comparisons at 7nm and 5nm technology nodes, we show that
MBFFs combined with optimized banking provide a compelling solution for power efficiency. Our findings demonstrate that
these techniques reduce dynamic power consumption by up to 30% compared to traditional flip-flops, without significant
performance degradation. This research highlights the potential of combining architectural changes with advanced node design
considerations to enable energy-efficient systems.
Comparative Study on the Seismic Analysis and Wind Analysis of Multistorey Building with Shear Wall and Diagrid
Authors: Borde Anita Popatrao
Published: February 2025

The present study investigates the behaviour of G+50 storey octagonal shaped building provided with shear wall at
different locations and diagrid, by inter-combining all these parameters of shear wall and diagrid; total six model of G+50 storey
building are prepared. The seismic and wind analysis of G+50 storey building is carried out by using structural analysis and
design computer program STAAD Pro. The dynamic analysis (Response Spectrum Method) of G+50 storey octagonal shaped
building with shear wall at a different locations and diagrid is carried out by using structural analysis and design computer
program STAAD Pro. All the models are developed for seismic zone III as per IS 1893: 2002 (part I) and for wind analysis zone
II is considered i.e. Aurangabad city having a basic wind speed of 39 m/s as per IS 875: 1987 (part-III). All the models are
analyzed by considering seismic forces and wind forces. The main aim of this research work is to find out the suitable location of
the shear wall and the model under seismic forces and wind forces which give optimum results. The behaviour of each model
with respect to others is checked for Base Shear (VB), Axial Force (FX), Twisting Moment (MX), Bending Moment (My), Bending
Moment (MZ), and Lateral Displacement (δ) at each and every storey are carried out for seismic forces and wind forces
separately. Finally, the behaviour of each model with respect to others for seismic force and wind force is described with the help
of graph.
Non-Linear Time History Analysis of Irregular Shaped Building
Authors: Thakur Yogini Vijaysing
Published: February 2025

Earthquake considerations are vital in the design of every structure. Many researchers have reported research works
aiming to understand the impact of structures with various irregularities. This study focuses on the behavior of structures with
irregularities and compares G+20 models of regular and irregular structures. The response spectrum analysis method is used
for analysis, and all structures are assumed to be in Zone V with medium soil type. The ground motion data of the El-Centro
earthquake in 1940 is used for the study. The analysis is conducted using the Etabs software. The study examines the structures’
responses to ground motion in terms of story displacement, story drift, and base shear. The responses of each type of building are
studied and compared. The results indicate that ground motions with low-frequency content have a significant impact on both
regular and irregular reinforced concrete structures. It is observed that irregularly shaped structures lead to an increase in
displacement, drift, story acceleration, time-period, and member forces, while reducing the base shear. This study suggests that
when planning for earthquakes, irregularly shaped structures require extra attention to avoid further losses.
Acidic and Enzymatic Hydrolysis of Corn Cobs for Biofuel Production
Authors: Jha Anushree
Published: February 2025

This study extensively explores the use of both acidic and enzymatic hydrolysis methods for the degradation of corn
cobs into fermentable sugars, which can be further processed into bioethanol. Corn cobs, as a significant form of lignocellulosic
biomass, offer a promising alternative for sustainable biofuel production due to their abundance and high polysaccharide
content. Acidic hydrolysis was carried out using dilute sulfuric acid, while enzymatic hydrolysis employed cellulase and
hemicellulase enzymes. These two methods were compared to evaluate their efficiency in converting the cellulose and
hemicellulose components of corn cobs into fermentable sugars. Multiple reaction conditions, such as temperature, enzyme
concentration, and reaction time, were optimized for both processes to maximize sugar yield. The study also evaluated the
production of degradation by-products, which could affect the fermentation process. The results showed that while acidic
hydrolysis provided a faster sugar yield, enzymatic hydrolysis offered a more controlled breakdown of the biomass with fewer
inhibitory by-products. This work provides insights into the optimization of biomass conversion for bioethanol production and
highlights the potential of corn cobs as a biofuel feedstock
Impact of interest rates & capital adequacy on stock returns: profitability's role
Authors: Ivansyah Dimas Fernanda , Widagdo Bambang , Sa’diyah Chalimatuz , Fitriasari Fika
Published: February 2025

Purpose: This research delves into the factors that determine stock returns within the banking sector listed on the IDX. The primary focus is on assessing the impact of interest rates and capital adequacy ratios, with a consideration of profitability ratios as mediating variables in the resolution
Methodology/approach: Quantitative methods were employed for this research, utilizing secondary data derived from the financial reports of each company. Data collection involved the scrutiny of documentation from the annual reports of 14 banks spanning the period from 2018 to 2022, employing a purposive sampling technique. Structural Equation Modeling (SEM) operated through the PLS program was employed for data analysis
Findings: The findings indicate that interest rates, capital adequacy ratios, and profitability do not exert any significant influence on stock returns within the banking sector. However, both interest rates and capital adequacy ratios significantly affect profitability. Moreover, profitability does not play a significant mediating role in the relationship between interest rates and capital adequacy ratios concerning stock returns
Practical implications: In conclusion, the study suggests that stakeholders should be cautious in overemphasizing traditional financial ratios, and explore broader strategies and variables when analyzing bank stock performance and setting policies
Originality/value: This study offers valuable insights into the factors shaping stock returns within the banking sector.
Determinants of the UMEGA model development in the use of the rental payment system
Authors: Puspita Dewi Ayu , Aufilana Fiftah Shafi , Shulthoni Moch.
Published: February 2025

Purpose: This research was conducted with the aim of analyzing the factors that influence the use of the rental payment system (SIMBAH-E) by adopting the UMEGA model as a technology acceptance model.
Methodology/approach: The data analysis method in this research used Structural Equation Modeling (SEM) with the Partial Least Square (PLS) approach. processed via the SmartPLS 4.0 application.
Findings: The results of this study show that there is a significant positive influence on the six independent latent variables on attitudes, there is one dependent variable that has a significant negative influence on attitudes, and one variable has no influence on attitudes and interest in use.
Practical implications: As well as latent variables of accounting information quality as a form of model development. The researcher used a questionnaire as a research measuring tool, and used a Likert scale in his assessment and used cluster random sampling in selecting respondents with a total of 100 respondents.
Originality/value: This research was conducted because the UMEGA model is the newest technology acceptance model so not many people have researched it, and this research contributes the latest thinking by adding a latent variable for the quality of accounting information as a development of the UMEGA model. Researchers used latent variables in the UMEGA model, namely performance expectations, effort expectations, social factors, risk of facilitating conditions, perceived risk, attitudes and interest in use.
Measuring Intellectual Capital Trends in Positivism Research: A Literature Review
Authors: Ahmad Nuryaddin Zayyan
Published: February 2025

Purpose: This article aims to see how diverse intellectual capital measurements are in positivist (quantitative) research in 2023.
Methodology/approach: This article resulted in literature rivew on the topic of quantitative research on Intellectual Capital on Scopus Q1 Indexed Journals i.e. Journal of Intellectual Capital in 2023
Findings: The finding of this article is that there are three contexts of the topic Intellectual Capital that will be studied in 2023 are Intellectual Capital Conventional Green Intellectual Capital and Intellectual Capital Disclosure. In addition, there is a dominance of topics Intellectual Capital conventional compared to the other two topics
Practical implications: The implications of this article can be used as an additional insight literature review Regarding the trend of quantitative research on intellectual capital.
Originality/value: The novelty of this research lies in the diversification of intellectual capital measurements in quantitative research.
Study Of The Antikythera's Makanism As A Classical Astronomical Instrument And Its Implications For Eclipses
Authors: Jannah Syikma Riyadlil , Ahmad Izzuddin
Published: February 2025

The circulation of celestial bodies at some point is on a straight line, including the phenomenon when the Earth, Moon, and Sun are in one line called an eclipse phenomenon. In predicting the occurrence of eclipses, scientists have created their works either in the form of calculations (tables) or with an instrument. In the 1900s, a bronze-based fragment was found which was then subjected to further research collaboration and produced an instrument called the Antikythera Mechanism. The instrument is also called an ancient computer that has high accuracy. As a test of the instrument's accuracy, scientists created a virtual reality model. This paper aims to open the treasures of classical astronomy (Falak Science) through classical instruments with a library research method. As for analyzing the data, the author uses a qualitative-descriptive approach. The results of this paper show that the Antikythera mechanism instrument is one of the classical instruments with very complicated components in ancient times which can then be used in determining the eclipse phenomenon. The prediction results contained in the instrument have high accuracy after testing the accuracy with NASA calculations.
Student Perspective: Religious Character Values in Upin and Ipin Animated Cartoons
Authors: Saputra Daffa Untara , Sanusi Anwar , Rahman K.A.
Published: February 2025

This study aims to determine students’ perspectives on character values in Upin and Ipin animated cartoons. This type of research uses qualitative methods with descriptive methods. Islamic character values are something that all Muslims must have. To form individual characteristics that foster honesty, always maintain their relationship to Allah SWT, always respect parents and respect others, character education media is needed. Cartoons or animations are not just entertainment but can be an educational medium for Islamic character values in an individual. The results showed that Islamic character values in Upin and Ipin cartoons or animations based on student perspectives in the episode “Spesial menyambut Ramadhan” have the following character values: Faith, Mutual Respect, Tolerance, and Mutual Respect, from these four character values can be concluded that these four values are the most dominant religious character values in Upin and Ipin animated cartoons in the episode “Spesial menyambut Ramadhan”.
The Effect of Purple Sweet Potato Flour (Ipomoea batatas L) as Wheat Flour Substitution on Physicochemical and Sensory Properties of Crackers
Authors: Kurniati Mila , Muhaimin Muhaimin , Ulyarti Ulyarti
Published: February 2025

The changes in main ingredients may affect the characteristics of cracker. This study aimed to determine the effect of purple sweet potato flour as a substitute for wheat flour on the physicochemical and sensory properties of crackers. This study used a Completely Randomized Design (CRD) consisting of 6 levels of purple sweet potato flour concentration as treatment (0%, 10%, 20%, 30%, 40%, and 50%) and 3 replications. The concentration of purple sweet potato flour has shown a significant effect on volume development, brightness value (L*), anthocyanin content, and sensory properties (color, taste and overall acceptance), but has not shown significant effect on the texture and sensory property (texture) of crackers. The substitution of 50% wheat using purple sweet potato flour produced the best crackers with hardness 1098.80 gF, development volume 19,33%, L* 72, a* 30, b* 4.33 and the anthocyanin contents of 162.02 mg of Cyanidin 3-glucoside/100g. The cracker contains 6.25% moisture content, 3.00% ash, 7.47% protein, 19.00% fat, 1.00% crude fiber and 64.28% carbohydrate.
Influence of seeding rate on photosynthetic activity of spring triticale crops
Authors:   Far Eastern State Agrarian University, Muratov Aleksey A.
Published: February 2025

Spring triticale is a new crop for the Amur Region. In order to introduce it into the crop
rotation the studies were carried out as follows: period of the research: Years 2014-2016; research
goal: determination of the optimal seeding rate. The following seeding rates were studied: 4, 5, 6, 7
and 8 million germinating seeds per hectare. As a result, it was found that the largest leaf area was in
the variant with the seeding rate of 8 million germinating seeds per hectare. At the same time, during
the tillering phase, at the seeding rate of 4-6 million of germinating seeds per hectare it was about 8-
9 thousand m2 / ha, and at 7-8 million germinating seeds per hectare - 10-12 thousand m2 / ha where
the difference was more than 20%. However, beginning from the booting phase, this difference did
not exceed 10-15%, indicating increase in thickness of crops as seeding rate is increased and as a
consequence it leads to fall in productivity per plant. When assessing the impact of the seeding rate
on productivity, it was found that the highest grain yield was in all the studied varieties when a seeding
rate amounted 6 million germinating seeds per hectare up to 30.8 centner / ha. At the same time, the difference in grain yield between the highest and lowest seeding rate in comparison with the variant
of 6 million of germinating seeds per ha did not exceed 11.8%. As a result, we can conclude that the
most optimal seeding rate in the Amur region is 6 million germinating seeds per hectare.
Comparative assessment of organoleptic properties of tubers of the studied potato assortment in the Middle Priamurye
Authors:   All-Russian Research Institute of Soya, Rafalsky Sergey V. , Rafalskaya Olga M. ,   All-Russian Research Institute of Soya, Melnikova Tatyana V. ,   All-Russian Research Institute of Soya
Published: February 2025

The research paper presents essential findings of investigation carried out in order to have
a comprehensive assessment of the organoleptic qualities of the studied varieties of potato under natural and climatic conditions of the Middle Priamurye. The assessment is based on the analysis of
organoleptic properties of the main table qualities of tubers and use of weightiness parameters. It is
carried out to identify promising genetic sources and include them in the selection process when
creating table varieties of potatoes of a universal type. Determination of the weightiness parameters
of each indicator, which are important for a comprehensive assessment of tubers and have a significant effect on the final result, was carried out by an expert method. Judging by the results of the rating
summary assessment of the set of qualitative characteristics of organoleptic properties expressed by
a complex score indicator, a high potential of the studied varieties, including domestic selection, was
found. The highest value of this indicator (3.99...4.10 points according to 5-point rating scale) was
observed in the varieties Nikita, Rodrigo and Krepysh. The above-said genotypes, as well as the varieties Primadonna, Vitessa, Jubilar, Latona, Odyssey, Ketsky, Vulkan, Lugovskoy and Chaika, having the value of the complex index from 3.66 to 3.89 points with good culinary advantages, can be
selected as characteristic genetic sources for the breeding of universal varieties of table potato.
Evaluation of protein content in seed material of somaclonal soybean lines
Authors:   All-Russian Research Institute of Soya, Kodirova Galina A. , Kubankova Galina V. ,   All-Russian Research Institute of Soya, Nizkii Sergey E. ,   All-Russian Research Institute of Soya, Fisenko Pyotr V. ,   All-Russian Research Institute of Soya
Published: February 2025

The goal of the research was to study the protein content and its amino acid composition
in the seeds of soybean variety samples (lines) obtained by the somaclonal variability method in culture in vitro using of cadmium ions in nutrient media. Somaclonal lines were obtained in the breeding
nursery of Federal Research Center for Agrobiotechnologies of the Far East named after A.K. Chaika
in accordance with the agrotechnics adopted for Primorskiy Krai in 2017–2018. Studies of the biochemical composition of soybean seeds were carried out at the All-Russian Scientific Research Institute of Soybean Test Laboratory. Variety samples were analyzed for protein content and its amino
acid composition by the near-infrared spectroscopy method using “FOSS NIR Systems 5000” analyzer. On the basis of the obtained data, we found lines with a significant excess of the standard level
concerning the following characteristics: protein content by 5.3–9.5%, histidine – by 56–82%, leucine
– by 3.8–5.0%, and isoleucine – by 18%. As a result of cluster analysis, three groups (subclusters) of
regenerants were singled out, which differ in a complex of biochemical features with improved characteristics. The lines of the first group (R1590, R1583) are characterized by high protein content –
40.4–42.2%. The second group is represented by lines (R1597, R1569) combining a high content of
protein (39.9–40.3%) and histidine (9.0–9.1%). The third one combines the middle-protein group of
somaclones (R1606, R1567, R1585) with an increased content of histidine (7.8–8.7%) and leucine
(8.3–8.4%).
History of spring wheat breeding at the Far East research institute of agriculture (review)
Authors:   Khabarovsk Federal Research Center of the FarEastern Branch of the Russian Academy of Sciences Far Eastern Agricultural Research Institute, Aseeva Tatiana A. , Zenkina Kristina V. ,   Khabarovsk Federal Research Center of the FarEastern Branch of the Russian Academy of Sciences Far Eastern Agricultural Research Institute
Published: February 2025

The article shows the prehistory of agriculture and wheat cultivation in the region under
the conditions of waterlogging, the first regionized varieties and the most important stages of selection work at the Far East Research Institute of Agriculture (Russia, Khabarovsk Territory). Strange,
foreign and collectable samples of various ecological and geographical origin had low resistance to
lodging and could not withstand the infectious diseases. Since steady increase in the volume and quality of the wheat crop in the monsoon climate zone is limited by unregulated environmental factors, so the creation of productive varieties with environmental resistance to stressful conditions is
one of the difficult and complex tasks of breeding. Here are the scientists and breeders who have
made great and invaluable contribution to the development of this scientific direction-V. A. Zolotnitsky, E. G. Lysykh, V. P. Konechny, G. S. Karacheva, I. M. Shindin, E. N. Meshkova, I. V. Lomakina.
One of the first parents of new wheat varieties in the Far East was the Thatcher variety (USA), which
had a high genetic resistance to lodging and diseases. The article gives a brief description of the
varieties of spring soft wheat created at the Institute-Dalnevostochnaya 6, Dalnevostochnaya 10, Oltava, Khabarovchanka, Zaryanka, Lira-98, Elizaveta, Priamurskaya, Anfea, Dalira. Currently, breeding at the Institute is focused on increasing productivity and mobilizing the adaptive potential of
wheat being under adverse soil, climate and weather conditions of the environment.
The Changing Faces of Academic Family Medicine Leadership: A CERA Secondary Analysis
Authors: Ringwald Bryce A. , Edwards Yasamine , Vengal Sarah , Montemayor Jon , Ringwald Carter
Published: February 2025

Background and Objectives: Diversity, equity, and inclusion (DEI) efforts strive to create a physician workforce that represents the general population. Barriers remain, however, regarding the promotion of women and underrepresented in medicine (URiM) physicians. We sought to describe gender and race trends in academic family medicine leadership over the past decade.
Methods: We performed a secondary analysis of Council of Academic Family Medicine Educational Research Alliance clearinghouse data, examining demographic survey responses from available surveys of family medicine clerkship directors (CDs), program directors (PDs), and department chairs from 2011 to 2023.
Results: During the time studied, family medicine CDs female representation expanded to 60.2% of CDs, an increase of 23%. CDs increased Asian representation by 127% without significant change in other racial groups. Family medicine PDs female representation expanded to 54.5% of PDs, an increase of 97%. PD Black representation expanded by 51%, and Asian representation expanded by 100%. Family medicine department chairs female representation expanded to 37.5% of chairs, an increase of 61%. Similarly, Black representation expanded by 95%, and Hispanic representation expanded by 150%. In total, 19.1% of chairs identified as URiM in 2023.
Conclusions: Family medicine has improved advancements into academic leadership positions. Family medicine CDs and PDs have achieved representative status of females but lag in URiM representation. Family medicine department chairs have made progress in both female and URiM representation but still lag compared to the general and family medicine physician population. Additional mentorship and sponsorship are needed to access the resources available in family medicine to further advance DEI in the representativeness of its leadership.
Assessing the efficiency of the external auditor in combating money laundering in the financial sector governance
Authors: Alnor Nasareldeen Hamed Ahmed , Al-Matari Ebrahim Mohammed , Al-Bukhrani Mohammed A. , Alhebri Adeeb , Omer Adam Mohamed , Mohammed Omer Alsir Alhassan
Published: February 2025

This study evaluates the efficiency of external auditors in combating money laundering in the Sudanese financial sector. It examines how auditors’ capabilities and characteristics influence their effectiveness in anti-money laundering (AML). Quantitative data were collected through a survey of 228 external auditors in Sudan. Partial least squares structural equation modeling (PLS-SEM) was used to analyze the data. Auditors’ skills in rigorous financial analysis and investigation significantly improve their AML performance. Additionally, a strong ethical orientation positively affects auditors’ effectiveness. However, practical experience did not enhance the detection of money laundering. Most notably, the adoption of advanced technologies and analytics tools had the strongest positive impact. The findings highlight the need for enhanced auditor training, greater investments in regulatory technology (RegTech), increased oversight of ethics, and expanded information-sharing between auditors, regulators, and financial institutions. This study provides unique empirical evidence on leveraging external auditors’ capabilities to combat money laundering, specifically within the Sudanese context. The research model demonstrated good explanatory power and predictive accuracy.
KTH Library´s history
Authors: Greta Quesada Richardson
Published: February 2025

This is an example of how a graphical exhibition could look like.
Comparison of the Effects of SGLT-2i versus GLP-1RA on Cardiovascular and Renal Outcomes in Patients with Type 2 Diabetes Mellitus based on Baseline Renal Function
Authors: Wang Yu , Xia Chao , Li Manna , Xu Gaosi
Published: February 2025

There remained no head-to-head research to evaluate the cardiovascular and renal benefits of sodium-glucose cotransporter 2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) in patients with type 2 diabetes mellitus (T2DM) at different baseline renal function. We performed a network meta-analysis to compare the two drugs indirectly. Systematic literature searches were conducted on PubMed, Cochrane Library, Web of Science, and Embase, covering their inception until January 7, 2025. Randomized controlled trials (RCTs) comparing the effects of SGLT-2i and GLP-1RA in T2DM with different glomerular filtration rates (eGFR) were selected. Results were reported as Risk ratios (RR) with corresponding 95% confidence intervals (CI). Finally, 10 RCTs involving 87,334 T2DM patients were included. In conclusion, In patients with eGFR > 90 mL/min/1.73m2, GLP-1RA exhibited a superior ability to reduce the risk of all-cause death (ACD) compared to SGLT-2i (RR [95% CI]; 0.75 [0.58, 0.97]), but was less effective in reducing the risk of renal outcome (RR [95% CI]; 1.80 [1.15, 2.84]) in patients with eGFR 60-90 mL/min/1.73m2. Conversely, in patients with eGFR 30-60 and 60-90 mL/min/1.73m2, GLP-1RA did not show an advantage in reducing the risk of hospitalization for heart failure (HHF) (RR [95% CI]; 1.87 [1.15, 3.04] and 1.37 [1.05, 1.78], respectively).
Understanding the Impact of Diabetic Peripheral Neuropathy and Neuropathic Pain on Quality of Life and Mental Health in 6,960 People With Diabetes
Authors: Borbjerg Mette Krabsmark , Wegeberg Anne-Marie , Nikontovic Amar , Mørch Carsten Dahl , Arendt-Nielsen Lars , Ejskjaer Niels , Brock Christina , Vestergaard Peter , Røikjer Johan
Published: February 2025

OBJECTIVE

Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts quality of life (QoL) and mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful and painless DPN and QoL, mental health, and socioeconomic factors, 2) assess the prevalence of sensory pain descriptors, and 3) evaluate the association between descriptors and the above factors.

RESEARCH DESIGN AND METHODS

Participants were grouped into people with (n = 1,601) and without (n = 5,359) DPN based on the Michigan Neuropathy Screening Instrument questionnaire. Participants with DPN were subsequently divided into people with (n = 1,085) and without (n = 516) concomitant neuropathic pain based on the modified Douleur Neuropathique en 4 Questions-interview.

RESULTS

The study showed diminished QoL (36-item Short Form Health Survey [SF-36]: 55.1 [interquartile range {IQR}36.7, 73.6], 82.2 [63.6, 90.9]) and poorer mental health (Hospital Anxiety and Depression Scale, subscale for anxiety: [HADS-A]: 5.00 [2, 9], 2.00 [1, 5]; HADS-subscale for depression [HADS-D]: 4.00 [1, 8], 1.00 [0, 3]) in participants with DPN compared with participants without DPN. The addition of pain diminished QoL (SF-36: 50.7 [34.8, 69.8]) and mental health (HADS-A: 6 [3, 10], HADS-D: 4 [1, 8]) further. The most prevalent pain descriptor in participants with painful DPN were burning pain (73%), while the most prevalent sensory descriptor was pins-and-needles (93%). An interesting finding is the high prevalence of itch (44%). Weak associations with mental health and QoL were present for cold pain, electric pain, and itch.

CONCLUSIONS

An increased focus on differences in QoL, mental health, and pain phenotypes is of importance to move the field forward toward more interdisciplinary, personalized treatment.