bluuebunny/crossref_metadata_2025 huggingface dataset:
Rewriting the Economic Growth History of Korea in the 1970s: Focusing on the Pollution Imports and the Shadow People of Economic Growth
Authors: Yang Jihye
Published: August 2023

During the period of rapid economic growth since the 1970s, Korea imported many polluting industrial facilities from Japan, resulting in the generation of huge amounts of hazardous waste. While the problems of environmental degradation such as these were an integral part of Korea’s development process, they have received only scant attention in the official history of the country’s economic development, often being dismissed as peripheral issues. This paper aims to go beyond this tendency by rewriting the history of economic growth that underlay the disputes caused by the importation of polluting industries from Japan in the 1970s. Its features can be summarized as follows.
First, Japan was the most damaging pollution exporter to Korea in the 1970s, and it was also the direct channel to import the knowledge of pollution, and alternative logic against the pollution issues.
Second, discussions over industrial pollution in the 1970s occurred in the antagonistic relationship between four groups: the government, media, opposition party, and scholars.
Third, a group of experts played various roles, including bureaucrats, researchers, and policy makers, leading the discussion of pollution in Korean society in the 1970s.
It has been well over 50 years since 1970. Nevertheless, Korean society still does not hesitate to create areas and people that become shadows in the wake of development. This explains why we should focus on the “sick body” rather than the “numbers” in this age of science and technology.
Olfactory Rehabilitation in Total Laryngectomy Patients
Authors: Kang Yung Jee , Choi Nayeon
Published: August 2023

Patients who undergo total laryngectomy often experience difficulties with their voice, olfaction, and taste due to the lack of airflow through nasal and oral cavities. While voice rehabilitation is more commonly performed, olfactory rehabilitation has gained importance in recent times with the use of various techniques. Previous studies have shown that incidence of hyposmia or anosmia (partial or total loss of smell) after total laryngectomy ranges from 25% to 100%. However, after olfactory rehabilitation, there has been notable improvement in olfaction, ranging from 46% to 88% of the patients. There are two main techniques for olfactory rehabilitation. The first involves creating airflow for smelling purposes by connecting the oral or nasal cavity to the tracheostoma using prosthetic laryngeal bypass devices. The second technique involves orofacial musculature training, which includes a nasal airflow-inducing maneuver known as the “polite yawning technique.” This maneuver creates negative pressure in the oropharynx, resulting in the induction of nasal airflow and potentially improving olfaction. Additionally, rehabilitation through biofeedback can facilitate airflow in the nasal cavity, further enhancing the sense of smell. In this review, we will introduce the principles, pathogenesis, and various techniques of olfactory rehabilitation, as well as summarize the outcomes of olfactory rehabilitation efforts.
A Study on Lip Movements Area and Vowel Space Area According to the Depressive Disorders
Authors: Kang Young Ae , Chang Jae Won , Koo Bon Seok , Lee Dong Heon
Published: August 2023

Background and Objectives This study aims to investigate the lip movements area (LMA) and vowel space area according to depression.Materials and Method The participants diagnosed with voice disorders or thyroid cancer before treatment and surgery. All participants completed the depression questionnaire and recorded five vowels (/a, i, u, e, o/) phonation while shooting. Among the total 64 participants, there were 19 participants in the depressive disorders group and 45 participants in non-depressive group. The analysis parameters were LMA, vowel space areas (Area3 & Area5), formant centralization ratio (FCR), fundamental frequency (F0) and voice intensity (intensity). Multivariate analysis of variance (MANOVA) was applied, and age was treated as a covariate to correct for lip movement that could deteriorate as age increased.Results As a result of MANOVA, there was no significant difference between groups (p=0.517). Looking at the LMA, both male and female in the depressive disorder group showed a lower mean value than the non-depressive disorders group. The Area3 and FCR of the depressive disorder group were higher than those in the non-depressive disorders group, whereas for the Area5, the mean value of female in the depressive disorder group was higher than that of the non-depressive disorder group and the male’s non-depressive disorder group had a slightly higher mean value.Conclusion The voice intensity according to the presence or absence of depressive disorder was similar, but the depressive disorder group tended to show narrower oral area with smaller lip opening.
Treatment of an Enlarged Periprosthetic Leakage Using Filler Injection in Patients With Provox Prosthesis: A Case Report
Authors: Lee Sang Mok , Jung Hyun Taek , Nam Yunbin , Kim Ji-Hoon
Published: August 2023

Recently, the most commonly used method for voice rehabilitation in total laryngectomy patients is to maintain tracheoesophageal shunt speech after inserting a voice prosthesis. One of the most common side effects, besides valve deterioration, is periprosthetic leakage due to dilatation of the tracheoesophageal shunt. Tissue implantation may be considered as one of the conservative treatments before attempting surgical treatment. When tissue implantation is attempted more than once, the treatment success rate is close to 90%. The authors experienced a case in which an 86-year-old patient developed aspiration pneumonia due to periprosthetic leakage. The patient refused surgical treatment. He was treated successfully for injecting hyaluronic acid filler 3 times and has been without a leakage for 9 months. This procedure can be considered as an alternative method to treat periprosthetic leakage.
Corporate governance systems and financial risks: A developing country evidence
Authors: Altawalbeh Mohammad Abdullah
Published: August 2023

Banks are one of the essential pillars of the financial sector (Alzuod & Alqhaiwi, 2022), however, banking is a high-risk industry (de Andres & Vallelado, 2008). The aim of this paper is to investigate the impact of the board’s structure and ownership structure on the financial risks of Jordanian commercial banks. Data was gathered manually from the financial reports. Notably, the study addressed two types of financial risks: liquidity risk and credit risk. The study sample included commercial banks listed on the Amman Stock Exchange (ASE) to cover the period 2014–2019. To achieve the study’s objectives, multiple regression analysis was run to test the hypotheses. The results reveal a negative, statistically significant impact of the board size, institutional ownership, and bank size on liquidity risk. The results also demonstrated a negative effect of board independence, ownership concentration, bank size, and CEO duality on credit risk. In sum, the results support previous studies that found a statistically significant role of corporate governance mechanisms in reducing financial risks. The study recommended the need to enhance foreign investment and institutional ownership.
A GaN based Power Amplifier Module for 5G Basestations
Authors: TÜRK BURAK , SAVCI HÜSEYİN
Published: August 2023

This study presents a compact and low-cost Power Amplifier Module (PAM)
for the RF power generation of 5G sub-6GHz massive Multiple Input and
Multiple Output small-cell base stations. The module is a hybrid design
realized on a 6mm x 10mm Rogers RO4350B RF laminate with bare-die
Gallium Nitride (GaN) High Electron Mobility (HEMT) transistors for
amplification and lumped components for filtering, matching, biasing
circuits, and stabilization networks. The operating frequency is
centered at 3.5GHz, a commonly deployed 5G New Radio (NR) band. The
module has two amplification stages, which operate in Class-AB mode with
differing conduction angles to equalize AM-AM and AM-PM responses for
higher compression point, linearity and power-added efficiency (PAE).
The design has a 24dB gain with 38 % PAE at 5W output power. The input
and output return losses are 8 dB and 6 dB, respectively. The large and
small signal measurement results agree with simulation results, with
some performance shifts over the frequency explained in the letter. The
back-fitting procedures are developed, and the measurement data is
verified with an optimized circuit.
Flood hazard risk prediction and assessment of Guangdong Hong Kong Macao Greater Bay Area based on random forest model
Authors: Zhang Haocheng , Wu Chunyi , Zheng Yanhui , Chen Xiaohong , wang lina , Zang Chuanfu
Published: August 2023

Against the backdrop of global climate change and rapid urbanization,
climate disaster events are frequent. In highly urbanized areas, floods
pose the greatest threat and destruction. Therefore, evaluating and
predicting the risk distribution of flood disasters through appropriate
methods can minimize the loss and damage of disasters, which is of great
significance. In this study, based on the Random Forest (RF) algorithm,
a model is constructed to evaluate and predict a flood disaster process
in the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) of China. We use
remote sensing (RS) images and GIS tools to extract the area submerged
by the flood when the disaster occur, select 15 risk indicators, create
221975 samples to train and test the model and obtain the importance of
each indicator to the prediction results. In addition, we select two
machine learning algorithm models for accuracy comparison with the RF
model. The results show that: (1) High flood areas are mainly
distributed in urban agglomerations in the central and southern parts of
GBA, including Guangzhou, Foshan, Dongguan, Shenzhen, Macau etc. (2)
Flood risk prediction and evaluation methods using RS and GIS, combined
with RF models, are easy to analyze the spatial pattern and influencing
factors of flood risk, and have good applicability. Compared with other
models, it has higher prediction accuracy and reliability. The
overfitting phenomenon is also not obvious. (3) The maximum 1/3/6/9 and
DEM elevation indicators are the most important five of the 15 risk
indicators, and the Relative Position Index (RPI) is the least
important, while other indicators are of general importance. This study
provides a new method for evaluating and predicting flood disaster
risks, and the evaluation results provide a reference for flood risk
management, prevention, reduction of life and property losses in the
study area.
A deep learning and physics-based method for multiaxial fatigue life prediction
Authors: Zhou Changjiang , Wang Haoye , Hou Shengwen , Jin Guanghu
Published: August 2023

The prediction of fatigue life for mechanical structures under
multiaxial loadings is considered an important task in engineering
design, but the conventional models are mostly limited to special
loading conditions and materials. In this work, a deep learning and
physics-based method is proposed for predicting the multiaxial fatigue
life. The relationships between the damage parameters and fatigue life
are quantified by establishing a deep belief network (DBN) model. The
hyperparameters of the DBN model are adaptively adjusted using a
particle swarm optimization (PSO) algorithm. Importantly, the input
features of the PSO-DBN model are determined based on the physical
model. The proposed method is validated through fatigue tests conducted
under various loading paths. The results demonstrate the high
effectiveness and applicability of the proposed method for accurately
predicting multiaxial fatigue life.
Numerical analysis and design of a high-frequency surface acoustic wave transducer: influence of piezoelectric substrates and IDTs configurations
Authors: Fernandez-Garcia Alonso , Solis-Tinoco Veronica Irais , Arce Miguel Angel Aleman , Villa-Vargas Luis Alfonso , Salinas Marco Antonio Ramírez , Garcia Juan Carlos Sanchez
Published: August 2023

The development of SAW transducers requires a series of steps ranging
from material selection, geometry design, as well as, the selection of
fabrication techniques for their characterization and validation
process. Here, we use the finite element method in COMSOL Multiphysics
to present a methodology and a detailed analysis of the design of a SAW
transducer in a delay line configuration. First, we simulate
single-finger and double-finger configurations of IDTs on LiNbO3 in
64°YX and LiNbO3 128°YX orientation, with the objective of 1) comparing
the simulation results with the analytical delta model to validate the
simulation process, presenting Pearson correlation values ranging from
0. 76 to 0.84. 2) calculate a maximum frequency value obtainable for
those configurations from a resolution of 5 microns in the
photolithography technique, used for the fabrication of SAW transducers.
Next, we extended the analysis to study a specific transducer design
made to operate at a resonant frequency of 97 MHz. In order to determine
the influence of piezoelectric material and IDT configuration we
compared identical designs on 128°YX and 64°YX orientations of LiNbO3
with single and double finger configurations and adding the SPUDT
configuration. We observed the best results for the single-finger IDT
configuration in 128°YX LiNbO3 orientation compared to the other
variants through its insertion loss level of -7.29 dB, its average
sidelobe level of 18.63 dB, and its average transition band slope for
the main lobe of 119.59 dB/MHz. The results obtained can serve as a
guide for new researchers or students to expand the use of numerical
tools in the design of SAW transducers and SAW devices.
Gas supply apparatus using rotational motion of shaking incubator for flask culture of aerobic microorganisms
Authors: Jung Minseo , Lee Jinwon , Park Si Jae , Na Jeong-Geol
Published: August 2023

Shake flask cultivation, a cornerstone in bioprocess research encounters
limitations in supplying sufficient oxygen and exchanging gases,
restricting its accuracy in assessing microbial growth and metabolic
activity. In this communication, we introduce an innovative gas supply
apparatus that harnesses the rotational motion of a shaking incubator to
facilitate continuous air delivery, effectively overcoming these
limitations. We measured the mass transfer coefficient
(ka) and conducted batch cultures of
Corynebacterium glutamicum H36LsGAD using various working volumes
to assess its performance. Results demonstrated that the gas supply
apparatus significantly outperforms conventional silicone stoppers
regarding oxygen delivery, with kLa values of 584.8
h compared to 22.1 h. Moreover,
in batch cultures, the gas supply apparatus enabled substantial
improvements in microbial growth, maintaining exponential growth even at
larger working volumes. Compared to the existing system, an increase in
final cell mass by a factor of 3.4-fold was observed when utilizing 20%
of the flask’s volume, and a remarkable 9-fold increase was achieved
when using 60%. Furthermore, the gas supply apparatus ensured
consistent oxygen supply and efficient gas exchange within the flask,
overcoming challenges associated with low working volumes. This approach
offers a simple yet effective solution to enhance gas transfer in shake
flask cultivation, bridging the gap between laboratory-scale experiments
and industrial fermenters. Its broad applicability holds promise for
advancing research in bioprocess optimization and scale-up endeavors.
ExplorePlus: Revolutionary Travel Experience Enhancement System.
Authors: R.R.W.G.B.P.P.M. Hulangamuwa
Published: August 2023

The tourism industry has been severely impacted by a series of
challenges in recent years, including the COVID-19 pandemic, the
Russia-Ukraine War, and supply chain disruptions. These adversities have
led to economic downturns and high inflation rates, making it difficult
for the industry to recover and thrive. The existing situation is
characterized by decreased travel demand, reduced revenue for tourism
businesses, and limited opportunities for travelers to explore new
destinations. One of the major problems faced by the current problem
domain is the need to revitalize the tourism industry and stimulate
travel activity. Traditional approaches to revive the industry have
proved insufficient, and financial constraints have made it difficult
for individuals to afford travel expenses. To address these problems, a
comprehensive mobile application is proposed, integrating the
move-to-earn concept. This concept incentivizes travelers to engage in
physical activities while exploring destinations, earning rewards like
digital tokens or discounts on travel-related services based on their
activity level. By encouraging physical activity and exploration, the
app revitalizes the tourism industry, boosting footfall and generating
revenue for local businesses. Additionally, the rewards earned through
the app provide financial relief and make travel more affordable,
thereby overcoming the economic challenges faced by both travelers and
the industry. Overall, this solution addresses the existing situation by
incentivizing travel and physical activity, promoting local businesses,
and mitigating the financial burden on travelers. It offers a
comprehensive and innovative approach to revitalize the tourism industry
and create a win-win situation for all stakeholders involved.
GOOSE Algorithm: A Powerful Optimization Tool for Real-World Engineering Challenges and Beyond
Authors: Hamad Rebwar Khalid , Rashid Tarik A.
Published: August 2023

This study proposes the GOOSE algorithm as a novel metaheuristic
algorithm based on the goose’s behavior during rest and foraging. The
goose stands on one leg and keeps his balance to guard and protect other
individuals in the flock. The GOOSE algorithm is benchmarked on 19
well-known benchmark test functions, and the results are verified by a
comparative study with genetic algorithm (GA), particle swarm
optimization (PSO), dragonfly algorithm (DA), and fitness dependent
optimizer (FDO). In addition, the proposed algorithm is tested on 10
modern benchmark functions, and the gained results are compared with
three recent algorithms, such as the dragonfly algorithm, whale
optimization algorithm (WOA), and salp swarm algorithm (SSA). Moreover,
the GOOSE algorithm is tested on 5 classical benchmark functions, and
the obtained results are evaluated with six algorithms, such as fitness
dependent optimizer (FDO), FOX optimizer, butterfly optimization
algorithm (BOA), whale optimization algorithm, dragonfly algorithm, and
chimp optimization algorithm (ChOA). The achieved findings attest to the
proposed algorithm’s superior performance compared to the other
algorithms that were utilized in the current study. The technique is
then used to optimize Welded beam design and Economic Load Dispatch
Problem, three renowned real-world engineering challenges, and the
Pathological IgG Fraction in the Nervous System. The outcomes of the
engineering case studies illustrate how well the suggested approach can
optimize issues that arise in the real-world.
EFFECT OF LAUGHTER THERAPY IN WOMEN WITH MIGRAINE
Authors: Erdoğan Meryem , Güvener Yasemin Özyer
Published: August 2023

Objective: Many women suffer from migraines, regardless of
their menstrual cycle. This study aimed to determine the effect of
laughter therapy on women with migraine. Design: This is a
randomized controlled study to determine the effect of laughter therapy
on migraine. Setting: Single center in Turkey.
Population: 52 women with migraine. Materials and
methods: This randomized controlled study was carried out with 52
female students with migraine (control: 28, experimental: 24) studying
in the faculty of health sciences of a university. The sample was
randomly divided into two groups using the draw lots method. The
experimental group received 20-30-minute laughter therapy once a week
for 8 weeks. Main outcome measures: Data were collected before
and after the therapy using an Individual Identification Form created by
the researchers, the Visual Analog Scale, and the Psychological
Well-Being Scale. Results: There was no significant difference
between the experimental and control groups in terms of the
Psychological Well-Being Scale (p>0.05). Eight participants
in the experimental group had no headache or migraine attack during the
laughter therapy. Furthermore, there was a significant difference
between the pre-therapy and post-therapy pain severity in the
experimental and control groups (p<0.05). Conclusion:
Laughter therapy can be effective in reducing pain and preventing
migraine attacks in women with migraine.
Characterization of Identified Dopaminergic Neurons in the Mouse Olfactory Bulb and Midbrain
Authors: Lau Maggy , Gadiwalla Sana , Jones Susan , Galliano Elisa
Published: August 2023

Dopaminergic (DA) neurons play pivotal roles in diverse brain functions,
spanning movement, reward processing, and sensory perception. DA neurons
are most abundant in the midbrain (Substantia Nigra pars compacta, SNC,
and Ventral Tegmental Area, VTA) and the olfactory bulb (OB) in the
forebrain. Interestingly, a subtype of OB DA neurons is capable of
regenerating throughout life, while a second class is exclusively born
during embryonic development. Emerging evidence in SNC and VTA also
indicates substantial heterogeneity in terms of morphology,
connectivity, and function. To further investigate this heterogeneity
and directly compare form and function of midbrain and forebrain DA
neurons, we performed immunohistochemistry and whole-cell patch-clamp
recordings in ex vivo brain slices from juvenile DAT-tdTomato mice.
After confirming the penetrance and specificity of the dopamine
transporter (DAT) Cre line, we compared soma shape, passive membrane
properties, voltage sags and action potential firing across midbrain and
forebrain DA subtypes. We found that each DA subgroup within midbrain
and forebrain was highly heterogeneous, and that DA neurons across the
two brain areas are also substantially different. These findings
complement previous work in rats as well as gene expression and in vivo
datasets, further questioning the existence of a single “dopaminergic”
neuronal phenotype.
Numerical Investigation of Multiphase Flow through Complex Fractures
Authors: Purswani Prakash , Santos Javier E. , Hyman Jeffrey De'Haven , Guiltinan Eric
Published: August 2023

Multiphase flow through fractures has great significance in subsurface
energy recovery and gas storage applications. Different fracture and
flow properties affect flow through a fracture which is difficult to
control in laboratory experiments. Here, we perform lattice Boltzmann
simulations in an ensemble of synthetically generated fractures.
Drainage simulations are performed at different capillary numbers,
wettability, and viscosity ratios. We track the invading front and
quantify breakthrough saturations and show that roughness and
wettability have a profound effect on fluid invasion through a complex
fracture. Invading a more viscous fluid results in more stable
displacement regardless of the capillary number while at very low
capillary numbers, fluid migration is dependent on the inherent
structure of the fracture. Through a systematic investigation, we
develop fluid displacement phase diagrams across multiple fractures, and
demonstrate the importance of natural fracture features of roughness and
wettability in establishing stable versus unstable displacement during
multiphase flow.
Modelling Online Shopping Behaviour Patterns among Higher Education Consumers: A Structural Equation Modelling (SEM-AMOS) Approach
Authors: Mat Zin Siti Hasma Hajar , Zakaria Siti Haslini , Moktar Balkiah , Che Md Nor Rumaizah
Published: August 2023

Online shopping is a phenomenon that is growing rapidly all over the world. Since 2020, Malaysian consumers have shifted their preference towards online shopping to fulfill their daily needs compared to shopping in a traditional store. Due to this reason, it is vital to identify the characteristics that affect consumers' online shopping behavior between various online websites for business owners to improve their online marketplace. However, only a few studies on online shopping behavior patterns among consumers across different online shopping platforms have been conducted in Malaysia. Therefore, this study was conducted to identify the factors influencing online shopping behavior patterns among Malaysian consumers. The factors involved were web characteristics, external stimulus, affection, and cognition. Data was collected using an online questionnaire, and a cross-sectional research design was used for this study. SPSS version 26.0 and AMOS version 21.0 were used to analyze the data gathered. A total of 371 students and staff were selected randomly from Universiti Teknologi MARA (UiTM) in Malaysia. The results show that the best online shopping platform in Malaysia that is preferred by respondents is Shopee. Only two constructs were statistically significant for online shopping behavior, web characteristics, and cognition. However, the direct effect of external stimulus and affection is not statistically significant. In conclusion, e-businesses should enhance the functionality, usability, and appearance of their websites. Effectively enhancing consumers' perceptions of online shopping could potentially have a positive influence on both their purchase intent and behavior.
Associations between adolescents’ cognitive distortion and misperceptions about cigarette smoking
Authors: Jia Cindy , Cheung Chau-Kiu , Li Li
Published: August 2023

Preventing the initiation of cigarette smoking is a core concern for adolescents? health in schools. Sufficient evidence has shown that one?s smoking behavior is susceptible to one?s misperception about the smoking status of proximate peers. However, the cognitive associates of the misperception remain largely uncharted. This study examines how cognitive distortion, which represents a cognitive error in information processing, associates with misperception of friends? cigarette smoking status. The study surveyed 334 dyads of college students to assess their cognitive distortion and misperception with instruments such as the Cognitive Distortions Questionnaire. Logistic regression analyses revealed that cognitive distortion significantly associated with underestimation of the friend?s smoking status, especially among non-smokers. It implies reducing cognitive distortion may be useful for preventing cigarette smoking.
The impact of the COVID-19 pandemic on the treatment of emergency urological patients during lockdown - Serbian tertiary center experience
Authors: Prijovic Nebojsa , Santric Veljko , Babic Uros , Stanic Danica , Stankovic Branko , Kovacevic Luka , Nikic Predrag
Published: August 2023

Introduction/Objective. The COVID-19 pandemic affected the functioning of health care systems, including emergency services worldwide. The aim of this study was to examine the impact of the pandemic and lockdown on the care of urgent urological patients in daily practice. Methods. Data were retrospectively collected from patients urgently hospitalized at Emergency Department of Clinic of Urology, University Clinical Center of Serbia, during the first three months of lockdown between March 15 and June 15, 2020, and compared to the same period in 2019. The collected data included demographic and clinical characteristics, as well as treatment characteristics and treatment outcomes. Results. This study included 80 patients who were hospitalized during the 2020 lockdown and 68 patients who were hospitalized in the same period in 2019. There was no difference in total number of hospitalized patients, age and sex when comparing these two periods. Among patients with urinary tract infection, the number of patients with urosepsis was significantly higher in 2020 (p = 0.028). The median time from symptoms? onset to hospitalization was significantly longer in patients who were hospitalized in 2020 (p = 0.049). No difference was found in duration of hospitalization and characteristics of treatment between the two periods. The number of deaths was significantly higher in 2020 (p = 0.034). Conclusion. During lockdown in Serbia, patients sought emergency urology service significantly later. Furthermore, a higher number of patients with urosepsis and a higher number of deaths among hospitalized patients were found during lockdown compared to the previous year.
Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma
Authors: Baculov Katarina , Djan Mihajla , Bajkin Branislav , Mijatov Ivana , Vuckovic Nada , Mijatov Sasa , Djan Igor , Barjaktarovic Iva , Stojcevic-Maletic Jelena , Vucinic Natasa
Published: August 2023

Introduction/Objective. Genetic aberrations and environmental factors are known to play an important role in oral squamous cell carcinoma (OSCC). The aim of the study was to clarify the association of epidermal growth factor receptor (EGFR) gene polymorphism rs1468727 with overall survival (OS) in patients with OSCC. Methods. The study comprised a total of 61 patients diagnosed with OSCC. The follow-up period for each patient was three years from the date of surgery and during that period their genotypes for rs1468727 polymorphism of the EGFR gene were identified using real-time polymerase chain reaction. Binary logistic regression was used to investigate the influence of various variables on survival. Additionally, the ?2 test of independence and Man?Whitney U test were done to examine the interplay between two categorical variables and two independent samples. Results. Two variables demonstrated a statistically significant influence on OS: the TNM Classification of Malignant Tumors (TNM) stage and EGFR genotype. At the end of the follow-up period, 39 patients survived, with a noteworthy observation that more than half of the survivors had the EGFR rs1468727 CC genotype. The distribution of CC and CT genotypes was equal (?2 = 0.397, df = 2, p = 0.820) among patients who deceased, indicating that no statistically significant correlations were found between OS and demographic or tumor-related characteristics. Conclusion. EGFR rs1468727 homozygote (genotype CC) and TNM stage showed statistically significant influence on OS in the follow-up period. This study highlights the potential significance of homozygote EGFR rs1468727 CC in assessing the prognosis and treatment outcomes of patients undergoing surgery for OSCC.
Ultrastructure of mast-cell granules in basal cell carcinoma.
Authors: Kobayasi T , Asboe-Hansen G.
Published: August 2023

No abstract available
Occupational dermatitis from pyrolysis products of polythene.
Authors: Hovding G.
Published: August 2023

No abstract available
A method for evaluation of the influence on experimental itch of topically
Authors: Rajka G.
Published: August 2023

No abstract available
Long-term treatment of rosacea with oral tetracycline.
Authors: Wereide K.
Published: August 2023

No abstract available
Electron microscopy of embryonic human epidermis at seven and ten weeks.
Authors: Matsunaka M , Mishima Y.
Published: August 2023

No abstract available
Malignant degeneration of skin lesions in epidermodysplasia verruciformis.
Authors: Ruiter M.
Published: August 2023

No abstract available
Late complications of syphilis. A comparative epidemiological and serological
Authors: Aho K , Sievers K , Salo OP.
Published: August 2023

No abstract available
Can psoriasis be quantitated?
Authors: Aschheim E.
Published: August 2023

No abstract available
Cutaneous lymphocytomas: clinical and histological aspects
Authors: Lange Wantzin GL. , Hou-Jensen K. , Nielsen M. , Petri J. , Thomsen K.
Published: August 2023

25 cases of cutaneous lymphocytoma were reviewed, of which 13 were benign lymphocytoma of the skin and 15 lymphocytic infiltration of the skin (Jessner). The clinical diagnosis benign lymphocytoma of the skin was in agreement with the histology, except in 2 patients where lymphocytic infiltration of the skin (Jessner) was the most likely clinical diagnosis. Of the 15 patients treated, 8 went into complete remission and 5 into partial remission. Eight patients suffered a relapse after partial and complete remission. The duration of the follow-up period varied between 2 months and 22 years. The histological diagnosis lymphocytic infiltration of the skin (Jessner) tallied in 9 patients with the clinical diagnosis, whereas in 6 patients the clinical diagnosis was benign lymphocytoma or pseudolymphoma. None of the patients developed systemic malignancy within the lymphoreticular system. A suspicious-looking skin lesion should always require further examination in order to exclude cutaneous manifestations of a systemic malignant lymphoreticular disease. The present histologic review demonstrates some uncertainty in diagnosing cutaneous lymhocytomas.1
Sensitization capacity of polyester methacrylate in ultraviolet curing inks tested in the guinea pig
Authors: Björkner B.
Published: August 2023

One of the prepolymers used in Ultraviolet (UV) curing ink formulations is acrylated polyester. The prepolymer investigated is a dimethacrylated polyester, thus a saturated polyester terminated with methacrylic groups. In conventional UV-curing coatings the prepolymer commonly used is an unsaturated polyester. Three of six workers with dermatitis from UV-curing inks in printing plants had positive test results from the polyester methacrylate present in the inks used. The sensitizing capacity, performed with the "Guinea pig maximization test", shows polyester or methacrylate to be a moderate sensitizer.
Effect on oral leukoplakia of reducing or ceasing tobacco smoking
Authors: Roed-Petersen B.
Published: August 2023

Oral leukoplakia patients who were smokers were asked to give up their smoking habits. It was found that leukoplakias present in persons with smoking habits might be reversible, when the smoking habit was reduced or given up. Leukoplakias which were not reversible could possibly be of the same idiopathic type as leukoplakias in non-smokers.
A novel wax stick preparation of anthralin
Authors: Chalmers RJ. , Marks JM. , Shuster S.
Published: August 2023

A new wax formulation of anthralin was compared with anthralin as used in the Ingram regimen for the treatment of chronic discoid psoriasis. In 16 out-patients 12 of the 13 who responded to the Ingram regimen also showed a satisfactory response to the wax preparation. The latter could be applied more rapidly and simply and may thus have a useful place in the domestic management of chronic psoriasis.
Antiserum to intercellular material and basement membrane produced by immunization with oral epithelial cells
Authors: Singh G. , Dolby AE.
Published: August 2023

Antisera to non-enzymatically released oral epithelial cells were produced in rabbits. Reactivity with gingival sections, by immunofluorescence, was observed for intercellular (IC) and basement membrane (BM) zones. Both IC and BM reactivity could be blocked with Concanavalin A (500 and 1000 micrograms/ml respectively) and anti-human fibronectin serum. Pretreatment with pemphigus serum blocked IC reactivity only. Pemphigus antigen may reside in the material present between coherent epithelial cells and be absent from enzymatically dispersed cells.
The deposition of immunoglobulins and complement in stratum corneum in microscopic lesions in patients with active psoriasis: the relationship to hyperproliferation
Authors: Johannesson A. , Hammar H. , Sundqvist KG.
Published: August 2023

The morphology of the horny layer was utilized to determine the age distribution of corneocytes in early psoriatic lesions and in their vicinity. By using the age distribution the number of corneocyte layers found in any time interval could be obtained and expressed as the rate of corneocyte layers formed. Deposits if immunoglobulins G, M and A and C3 were also age-distributed in a similar way. In the period during which the horny layer was formed, variation in the rate of corneocyte formation could be related to the appearance of immunodeposits. Hyperproliferation was found to precede deposits of immunoglobulins G, M and A and C3 by one to several days. Deposits were examined both visually and by means of microfluorometry, with the same result. The specificity of the deposits was established in two ways. A Fab2-anti-immunoglobulin conjugate was used to detect a possible Fc receptor binding. This was not demonstrated. Albumin was used as a plasma filtrate marker. Albumin was not found in the horny layer but was abundant in the intercellular spaces in the rest of the epidermis. It was concluded that the immunodeposits found in the early lesions of psoriasis are a secondary phenomenon during the initiation of a psoriatic lesion.
Histamine release from rat peritoneal mast cells exposed to ultraviolet light
Authors: Fjellner B. , Hägermark O.
Published: August 2023

After irradiation with ultraviolet light, rat peritoneal mast cells incubated with the histamine liberator compound 48/80 were found to have reduced capacity to release histamine. The action spectrum for histamine release inhibition seemed to be in the wavelength region of UVB. UV-light per se did not induce histamine liberation other than for dosages greater than or equal to 1.45 J/cm2. No such release was observed with the doses of UVA studied (3.4-20.5 J/cm2). The metabolic inhibitor 2.4-dinitrophenol (DNP), which almost completely inhibited compound 48/80-elicited histamine release, did not influence the UV-induced histamine release, indicating that the latter was not a secretory process but due to cytotoxic leakage of histamine from the cells. These results suggest that inhibition of histamine-releasing capacity or reduction of skin histamine due to photolysis of mast cells may explain the beneficial effect of UV in pruritic disorders where histamine release from mast cells is involved.
Comparison of two application schedules for clobetasol 17 propionate
Authors: Vd Harst , De Jonge H.  , Pot F. , Polano MK.
Published: August 2023

No abstract available.
Pressure inhibition of the Koebner reaction by capillary occlusion
Authors: Miller RA. , Griffiths WA.
Published: August 2023

A 38-year-old male with extensive psoriasis received a linear experimental abrasion. Immediate pressure was applied for 24 hours to the central portion of the traumatized site. During a psoriatic relapse 5 weeks later, Koebnerization occurred in the abraded areas but spared the site where pressure had been previously applied. The mechanism is not known but may be due to a local suppressive effect of pressure on inflammation.
Patch testing with perfume mixture
Authors: Veien NK. , Hattel T. , Justesen O. , Nørholm A.
Published: August 2023

145 of 1116 patients patch tested with the standard series of the International Contact Dermatitis Research Group, including the recently introduced perfume mixture, had positive patch test reactions to at least one of the traditional screening agents for fragrance allergy or to the perfume mixture. In 96 of 145 patients the positive patch tests could be explained as being related to fragrance allergy. The perfume mixture was considered a useful screening agent for fragrance allergy. However, the results indicate that it is still necessary to employ several screening agents to detect this type of hypersensitivity.
Co-existence of venereal infection and pediculosis pubis
Authors: Munkvad IM. , Klemp P.
Published: August 2023

No abstract available.
Identification of mononuclear cells in cell suspension from cutaneous infiltrates freed by a suction blister method
Authors: Ahokas T. , Niemi KM. , Halme H.
Published: August 2023

Mononuclear cells were liberated from superficial skin inflammations by a suction blister method which yielded a sufficient number of cells for histochemical and immunocytochemical analysis. The cell population consisted mainly of T cells which were identified as sheep red blood cell rosettes. Very few B cells were found as rosettes with immunobeads. Macrophages and eosinophils were found in varying numbers and they were identified histochemically. The method is suitable for studying nontumorous skin infiltrates.
Reactions of epidermal keratinocytes in sensitized and non-sensitized guinea pigs after dichromate exposure: an electron microscopic study
Authors: Lindberg M. , Forslind B. , Wahlberg JE.
Published: August 2023

The reaction in epidermal keratinocytes in sensitized and non-sensitized, normal guinea pigs after dichromate exposure has been investigated by electron microscopy. The results of the investigation show that the morphological alterations in keratinocytes in irritant and contact allergic reactions to dichromate are of a nonspecific nature. This underlines the fact that morphological reactions in the keratinocyte are uniform. The reactions were dose- and time-dependent. The morphology of the contact allergic reaction to dichromate in the guinea pig is consistent with that described for DNCB.
Sjögren-Larsson syndrome: microscopic and scanning electron microscopic findings in replicas of the skin
Authors: Jagell S. , Hofer PA.
Published: August 2023

Replicas of the skin below the cubital fossa were made in 29 SLS patients with an age range of 8 days to 69 years. The skin surface patterns differed from those in healthy controls. The papillomatosis observed in most SLS replicas seemed to appear during the first year or years of life and to increase in some patients with increasing age, but seemed to diminish again in middle-aged and older SLS patients. Other common features were the occurrence of longitudinal and transverse furrows. All these findings in SLS patients could, at least in part, represent an exaggeration of the normal skin surface pattern. The use of replicas for diagnostic purposes is commented on.
Treponema pallidum in peripheral nerve tissue of syphilitic chancres
Authors: Secher L. , Weismann K. , Kobayasi T.
Published: August 2023

Biopsies for electron microscopy were obtained from syphilitic chancres of 7 patients, 6 males and one female. In 4 of the patients, Treponemata pallida were seen gathering around peripheral nerves and invading the spaces between Schwann cells and their basal lamina. No definite degenerative changes were seen in the axons. In all patients, Treponemata pallida were gathering around the small blood vessels. The fine structure of Treponema pallidum in the lesions included a twined cytoplasmic cylinder with an inner and an outer lamina, an axial fibril consisting of three to five parallel filaments, each consisting of six microtubules, and a covering, outpouching periplastic membrane.
Detection of repeated gonorrhea by a modified follow-up method
Authors: Sandström E. , Jonsson A. , Holterman M. , Wallmark G.
Published: August 2023

The rate of reinfection after treatment was studied in four groups of patients. The first group of 100 patients were evaluated retrospectively after treatment with 1.0 g ampicillin twice followed by two re-examinations over a 2-week period during which time intercourse was prohibited. The second and third prospectively groups consisted of 100 and 200 patients respectively, treated with 1 g ampicillin twice and 1.4 g pivampicillin + probenecid respectively, with re-examinations at intervals of 1 week and 4 weeks after treatment. In these two groups sexual intercourse was allowed during the last 10 days of the follow-up period. The fourth study group consisted of all patients infected with gonococci having MIC greater than or equal to 0.3 micrograms/ml for ampicillin and/or benzylpenicillin, who were treated with 1 g ampicillin twice during the period of 1973-76. In the first group no positive cultures were obtained at re-examination. In groups two and three, 35 out of 300 (12%) were found to have positive cultures at re-examination. Some of these were probably treatment failures. The failure rate in group four was found to be 20%, indicating that the treatment regimen used left a narrow therapeutic margin. However, the risk of re-infection, in this urban clinic, seems to be higher than the risk of treatment failure which would have remained undetected had sexual intercourse been forbidden.
5% Aluminium chloride hexahydrate and sebum excretion rate
Authors: Simpson NB. , McGregor KA.
Published: August 2023

The present study was designed to assess whether 5% aluminium chloride hexahydrate in absolute alcohol exerted any effect on sebaceous gland excretory activity. Eleven acne patients controlled with long-term antibiotics applied active and placebo solutions in a double-blind trial. The sebum excretion rate was measured on two control visits and thereafter at fortnightly intervals for a further 6 weeks. Patients preferred the ´active´ solution, many claiming increased dryness of their skin. However, neither the ´active´ nor ´placebo´ solution had a significant demonstrable effect on sebum excretion rate. The beneficial effect of topical aluminium chloride hexahydrate is therefore assumed to be due to factors other than an alteration in sebum excretion.
The influence of topical steroid application on tuberculin skin reactions in healthy persons
Authors: Thestrup-Pedersen K. , Ahlburg H. , Hansen P. , Larsen PO.
Published: August 2023

Thirty-seven healthy persons were studied in order to evaluate the influence of topical steroid application on tuberculin skin reactions. Four areas measuring 4 cm in diameter were each treated with 50 micrograms of hydrocortisone cream 1%, or 50% micrograms of halcinonide (Halog) cream 0.1%, or 50 micrograms of unguentum cetacei simplex (cold cream), or not treated. The creams were applied once daily for 3 days before and one day after a tuberculin skin test. After 24 and 48 hours the area of induration were measured. We observed that application of unguentum cetacei simplex increased the size of the induration at the 24-hour reading, but not after 48 hours. Hydrocortisone cream 1% gave the same effect, whereas halcinonide cream (Halog) 0.1% caused ischaemia of the skin and reduced the induration of the skin test after 24 hours, but not after 48 hours. In 12 persons we found that simple rubbing of the skin with halcinonide cream base did not affect the size of the tuberculin skin reaction. In the present study we found that even very potent local steroid application on intact skin could only delay the development of tuberculin skin reactions, but could not diminish their size.
Long-term follow-up of photochemotherapy in pityriasis lichenoides
Authors: Boelen RE. , Faber WR. , Lambers JC. , Cormane RH.
Published: August 2023

Five patients with a histopathologically confirmed diagnosis of pityriasis lichenoides were treated with PUVA or irradiated with a light source emitting UVB and UVA, without prior intake of psoralens. All patients showed a good response to treatment. Long-term follow up showed that patients remained free of lesions during a period of 20 to 36 months; 3 patients had a recurrence of the disease, though less extensive than before, after 25, 23, and 23 months, respectively.
Pemphigus erythematosus induced by thiopronine
Authors: Alinovi A. , Benoldi D. , Manganelli P.
Published: August 2023

A patient affected by rheumatoid arthritis developed pemphigus erythematosus after 14 months of treatment with thiopronine. The lesions healed spontaneously after 4 weeks´ withdrawal of the drug. Whereas the pemphigus erythematosus induced by D-penicillamine is a quite rare but well documented side effect, we believe our case to be the first one reported as being due to thiopronine. It is very interesting to note that the two drugs are very similar with regard to chemical structure, mechanism of action, therapeutic indications and also side effects.
Benzoyl peroxide: lack of sensitization
Authors: Cunliffe WJ. , Burke B.
Published: August 2023

A prospective study of 445 patients using benzoyl peroxide, observed regularly over a 12-month period, uncovered only a very low incidence of moderate or severe local reaction. There was, however, a significant level of mild primary irritant dermatitis which settled with continued use. In only 6 patients was there severe local reaction; one patient was lost to follow-up but in the 5 patients patch tested, only one had a contact allergic dermatitis. The study indicates the overall cutaneous safety of benzoyl peroxide.