bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful of SK305 Artificial Reefing Decommissioning Project
Authors: Sulaiman Mohd Zhafran , Ros Mohamad Ikhranizam , Azizan Mohd Azwan
Published: November 2018

This paper will discuss on recent SK305 decommissioning project which had completed in November 2017. These two platforms had been total removal and been an artificial reef at Sarawak water in Malaysia. This paper will share on activity and best practices from early stage until completion which divided into phases Engineering, Preparation, Removal and Disposal and Post Decommissioning /Reefing activity. Preparation activities needed for decommissioning and reefing project start with Baseline survey at reef location, underwater inspection, and topside inspection. During the Engineering stage, facilities integrity checks, removal engineering and Transportation engineering been carried out. Cutting basis and cutting equipment been developed and identified. Performed reefing engineering to ensure lowering of the facilities is in control condition and reefed facilities are stable. Topside and jacket removal via single lifting accordingly been execute follows the procedure and engineering for smooth execution. Post decommissioning survey been carried out to assess the successful of the project. Baseline inspection, underwater inspection had provided some information to the contractor on the scope and reveal some of the uncertainties about the decommissioning project. Engineering study is critical when to ensure safe operation. Observed that actual operation is similar to the engineering's simulation where team had follow the engineering accordingly. Reefing engineering performed to ensure the facilities been placed at the right location and position. During offshore execution removal of facilities there are challenges we faced malfunction of the cutting/dredge equipment had led to use back up plan and innovative solution to utilized other available equipment available onboard (Diamond wire cutter, abrasive water jet internal cutter, dredger, soil plug removal, airlift, cutting torch etc.). Sequence of cutting also need to be consider to minimize the pinch effect of the facilities. Decommissioning Safety Case been developed for this project to registered and to close the remedial action plan which will help project not to oversight any critical activity and aspect that had been identified. Finally, the post decom/reefing survey had been carried and the result observed new marine growth and numbers of fishes at reefed platform and had concluded the successful of this decommissioning reefing project. This paper should be an interest to those who will exploring abandonment and decommissioning project which considering reefing as one of the decommissioning option. This paper will share on it process on materializing reefing of 2 platforms through Engineering, Preparation, Removal and Disposal (EPRD) approach contract. The novelty in this paper is on assurance that been made by Company via baseline and post reefing survey to ensure environment aspect been consider.
Effects of Boron Omission and Foliar Fertilization on Nutrition Efficiency and Production of Cowpea
Authors: Silva Sylvia Letícia Oliveira , Prado Renato de Mello , da Silva Gilmara Pereira , da Silva Júnior Gabriel Barbosa , Rossi Monica Lanzoni , González Leónides Castellanos
Published: November 2018

This study aimed to evaluate the effects of boron (B) omission on cowpea nutrition and to compare the impact of foliar B fertilization with and without sorbitol on cowpea growth, nutritional status, and B uptake. Two trials using a completely randomized experimental design were conducted. During the first experiment, nutrient solution was provided without B (−B) and with B (+B) in 10 replicates. During the second experiment, a 5 × 2 factorial treatment scheme was used. Five B concentrations (0, 1.25, 2.5, 3.75, and 5.0 g·L−1) were administered foliarly in the form of boric acid with or without sorbitol (500 mmol·L−1) in four replicates. B omission symptoms, root growth, plant organ dry mass and B content, and grain yield were evaluated. B omission induced greater losses in reproductive organ and root growth than in leaf and stem production. It also caused deformation of the middle lamella and accumulation of starch in the chloroplasts. Foliar applications of 2.6 to 2.9 g·L−1 B improved cowpea production. The addition of sorbitol did not enhance plant growth. However, it increased B absorption in the vegetative parts of the plant but did not enhance seed production.
Message Strategies and Media Formats of Florists’ Facebook Posts and Their Effects on Users’ Engagement Behaviors
Authors: Huang Li-Chun , Chen Li-Chun
Published: November 2018

Social media marketing has been widely adopted by florists with the use of the Facebook brand page. However, many florists fail to achieve their expected success in that realm because of not being fully conversant in posting on social media. To address this deficiency, this study aims to 1) develop a taxonomy of florists’ Facebook posts to clarify florists’ message strategies on Facebook brand page and 2) investigate the effect of posted messages and media formats on the marketing performance of florists’ Facebook brand pages by evaluating users’ engagement based on the number of likes, comments, and shares from users for each post. Using data derived from 1646 empirical Facebook posts initiated by florists, it was found that florists’ Facebook posts could be classified into four broad message types covering 12 categories. The statistical results for analysis of variance (ANOVA) and post hoc tests revealed that the posted message and media format had significant effects in terms of causing users to like, comment on, or share florists’ posts. Compared with other message categories, posts in the message categories of product information, gratitude to customers, and holiday greetings had more favorable effects in terms of causing users to like, comment on, or share florists’ posts. As for the effect of media format, it was the posts in the photo media format that attracted more likes, comments, and shares from users compared with those in other media formats. Florists who operate brand pages on Facebook can be guided by our research when making decisions regarding the post characteristics in message orientations and media formats for attracting favorable responses from users.
Reducing Substrate Moisture Content during Greenhouse Production of Poinsettia Improves Postproduction Quality and Economic Value
Authors: Guo Yanjun , Starman Terri , Hall Charles
Published: November 2018

The objective was to determine the effect of substrate moisture content (SMC) during poinsettia (Euphorbia pulcherrima) greenhouse production on plant quality, postproduction longevity, and economic value. Two experiments were conducted, one in 2016 with ‘Freedom Red’ and the other in 2017 with ‘Christmas Eve Red’. Treatments included two SMC levels (20% or 40%) applied in four timing of application combinations. Total production (TP) time was 14 (2016) or 12 (2017) weeks in which vegetative production (VP) occurred from week 33 (2016) or 35 (2017) to week 39 and reproductive production (RP) continued from week 40 to 47. The four timing of application treatments were 40/40 = TP at 40% SMC; 20/40 = VP at 20% + RP at 40%; 40/20 = VP at 40% + RP at 20%; 20/20 = TP at 20% SMC. After simulated shipping in the dark, plants were evaluated in a simulated retail environment with two packaging treatments: no sleeve covering or plastic perforated plant sleeves covering container and plant. At the end of greenhouse production, plants grown in 20% SMC during RP (20/20 and 40/20) had shorter bract internode length, stem length, and smaller growth index (GI), decreased shoot and root dry weight (DW), and bract and leaf surface area compared with those in 40% SMC during RP (40/40 and 20/40). Photosynthetic rate was higher when plants were watered at 40% SMC regardless of production stage compared with those in 20% SMC. Leaf thickness, petiole thickness, total bract and leaf number were unaffected by SMC treatments. Plants in 20% SMC during RP (20/20 or 40/20) had earlier bract coloring despite days to anthesis being the same for all SMC treatments. Compared with 40/40, 40/20, and 20/20 could save 44.2% or 43.6%, respectively, irrigation and fertilizer usage, and 39.1% and 47.8%, respectively, labor time. During postharvest, ethylene concentration was unaffected by packaging method. Sleeved plants, regardless of SMC treatment, received lower light intensity in the middle of the plant canopy, causing plants to have lower total leaf number due to abscission and SPAD reading at the end of postproduction. The 40/40 treatment abscised more bracts during five weeks (in 2016) of postproduction and with no sleeve had higher number of bracts with bract edge burn (BEB). In summary, reducing SMC to 20% during TP or RP reduced water usage during production and produced more compact plants with increased postproduction quality.
Formation of a team of project executors in the area of creation aviation techniques
Authors: Feoktystova Olena , Rovinska Nastasia
Published: November 2018

In the article there is analyzed the present condition of the problem of high-tech project management to develop the new objects by the aviation profile enterprises. The analyses showed that for improvement of the efficiency of portfolio management it should be developed special methodic tools of decision support system by HR and Project managers about executors’ composition forming of high-tech projects taking into account number of indicators of different character and first of all employee competence. Based on the analyzed results the integrated process model was developed which described the main stages of team formation of high-tech projects executors. There is formation of expert committee of employees of aviation profile enterprises for the choice of rational variant of team composition from the several alternatives; estimation of the candidates’ competencies level for the including to the high-tech project team, the communication level assessment of the future team participants, selection by the collective expert estimation, united variant of executive team of high-tech project. This model provides increasing of the level of objectivity of finally decision about composition of team executors of high-tech project unlike other famous models. Practical value of proposed model is in decreasing of the risks of incorrect decision making by HRs and project managers during the process of formation of team executors of high-tech project. Based on developed methodical tools, in the article there is described process of formation of team executors of high-tech project on the typical aviation profile enterprises PF “Space”. This company is specialized on development of airdrome techniques in particular self-propelled passenger ladder. Also in this article there are described methods and computation effect from integration of theoretical results into the practice of management by the high-tech projects on the aviation profile enterprises. Practice value of received results is in creation of science methodic basis in aggregate models view and methods of decision making support of HR and project managers for the formation of team executors’ composition of high-tech projects. These results can be used in portfolio management not only on the aviation profile enterprises but in any other innovation companies
Mathematical modelling of the reaction of condensation telomerization and the investigation of the model
Authors: Yevtushenko Julia
Published: November 2018

A mathematical model of the distribution of mixture components in the equilibrium condensation telomerization is developed depending on the ratio of the amounts of monomers and telogen, as well as the number of HX as regulating parameters, the computer implementation of the model is carried out, and its study is carried out by numerical simulation. The model is based on the well-known schematic diagram of the flow of the condensation telomerization process under the assumption of equal reactivity of the same functional groups (Flory principle). Based on the analysis of the flow pattern of the process, 6 structural elements are identified, reproducible at each stage associated with an increase in the degree of polymerization based on 4 basic components. It is proved that the equilibrium concentrations of these elements, depending on the polymerization degree, depend on the equilibrium concentration of products with a degree of polymerization 1 and are described by infinite geometric progression with the same denominator. According to the physical content of the task, this progression must be convergent. Equations of material balance of components are contained in the form of a system with 4 equations containing infinite sums. It is possible to minimize these sums using the properties of geometric progressions and to obtain a closed system with 4 nonlinear equations for the equilibrium concentrations of the base components. The Monte Carlo method is used to study the features of the numerical solution of the system of equations of the model. It is found that with a random choice of initial approximations of solutions from an admissible region, the system contains 4 roots, of which 2 contain positive and negative components and are false, and 2 have completely positive components. A valid criterion for finding a real root has a physical meaning based on the calculation of the denominator of a geometric progression. The possibilities of practical use of the model are discussed
Investigation of computer-oriented technologies for the optimization of electric supply and energy saving of railway transport
Authors: Kulbovskyi Ivan , Holub Halyna
Published: November 2018

The analysis of the current state of power electric equipment of traction substations of railways, power supply systems for traction and control systems based on what was shown that current trends to ensure a high level of efficiency of the power industry are directly related to its informatization and the development of distributed computer systems and networks intellectual technology for monitoring, identifying and intellectualizing the management of energy saving modes of electric supply systems. The temporary decomposition of the tasks of management of electric networks of railways and the methodology of the organization of intelligent electric power traction networks are proposed. The methods for registering primary information monitoring parameters of normal and emergency modes of electric networks based on the use of mathematical tools of differential transformations and the presentation of data in the form of T-spectra are developed. On the basis of the system-wide principle of a single information space and the results of experimental studies, the architecture of the computer environment is studied, which reflects the range of possibilities for intellectualizing the traction network based on the characteristics of electricity supply to railways, taking into account restrictions and specificity of consumption. And at its base, modern computer-intelligent technologies have been created for managing energy saving in the process of power supply to railways at the level of traction substations, power supply distances and the upper level of the railway as a whole. The possibilities of the proposed structure of the intellectual traction electric network of Ukrzaliznytsia developed as a result of the mutual integration of the topology of the traction network of power supply and architecture of the computer environment, which is the infrastructure for managing power supply for railway transport, as well as the possibility of integrating real-time monitoring, state, optimization of consumption and management of energy saving in the process during the maintenance of electricity for traction at all levels of management of the railway in market conditions
İDARİ YARGILAMADA MAKUL SÜRE KAVRAMININ AVRUPA İNSAN HAKLARI MAHKEMESİ KARARLARI IŞIĞINDA İNCELENMESİ
Authors: KESKİN Bayram
Published: November 2018

Yargı alanında insan haklarının en önemli
yansıması adil yargılanma hakkıdır. Adil yargılanma, hukuk devletinin en önemli
ilkelerinden biridir. Bu hak, yargılama faaliyetlerinin yerine getirilmesinde
uyulması gereken esasları belirleyen ve yargılama süreci ile birlikte,
yargılama öncesi ve sonrası dönemi de kapsayan bir haktır. Bu hak ile ilgili
ulusal ve uluslararası metinlerde bir takım hükümler getirilmiştir. Adil
yargılanma, Avrupa İnsan Hakları Sözleşmesi (AİHS) gibi birçok uluslararası
sözleşme veya beyannamede yer alan, hukuk sistemimizde de anayasal düzeyde
kabul edilmiş temel bir haktır. Makul sürede yargılanma hakkının çerçevesi,
adil yargılanma ilkesinin de temel öğesini oluşturmaktadır. AİHS, makul sürede
yargılanma hakkı güvencesinin sağlanması amacıyla mutlak bir süre
öngörmemiştir. Ancak, AİHS’nin iç hukukta uygulanıp uygulanmadığının yargısal
denetimi ile görevli olan Avrupa İnsan Hakları Mahkemesi (AİHM), makul sürenin
belirlenmesi amacıyla bir kısım ölçütler getirmiştir. AİHM, görülmekte olan
davalara ilişkin her bir somut olayın özellikleri yanında bu ilkeleri de göz
önüne almaktadır. Başvurucular, idari uyuşmazlıklar ile ilgili AİHM’ne
yaptıkları başvurularda en çok, davaların uzun süre geçmesine rağmen
sonuçlandırılmamasından yakınmaktadır. AİHS’nin getirdiği kriterlere paralel
olarak anayasal ve kanuni düzenlemeler yapılmış, buna rağmen gelinen noktada
bir takım eksik ya da aykırı düzenlemelerin var olduğu anlaşılmıştır. AİHM,
adil yargılanma hakkının önemli unsurlarından olan makul sürede yargılanma
hakkı, silahların eşitliği, çelişmeli yargılama hakkı ve mahkemeye başvuru
hakkı gibi konularda AİHS’nin 6’ıncı maddesine bir takım aykırılıkların
olduğunu tespit etmiş; söz konusu aykırılıklar nedeniyle de Türkiye aleyhine
bir çok ihlal kararı vermiştir. AİHM, idari uyuşmazlıklara ilişkin verdiği bazı
kararlar ile ülkemizde idari yargılama hukukunun gelişimine katkıda
bulunmaktadır.
ANAYASALAR, SİYASİ KÜLTÜR VE “HAIDA GWAII’NİN RUHU”
Authors: POLAT AKGÜN Deniz
Published: November 2018

Siyasi kültür ve anayasalar arasındaki ilişki, uzun süredir tartışma konusudur. Özellikle derinden bölünmüş toplumlarda söz konusu ilişki daha çok önem arz etmektedir. Siyasi kültürün anayasalar ile ilişkisinde ve buna bağlı olarak anayasal değişimlerde, diğer toplumsal koşuların da etkili olduğu göz ardı edilmeden; bir toplumun siyasi kültürünün, o toplumun anayasasına yansımasının ne ölçüde önemli olduğu, çalışmanın ana sorunsalını oluşturmaktadır. Bu çerçevede, sanat tarihinin önemli yapıtları arasında kabul edilen Haida Gwaii’nin Ruhu isimli heykelin bize anlattıklarından yola çıkılarak, etno-kültürel yapısı çeşitli ve değişken olan toplumlarda yaşanan çatışmalara değinilecek ve anayasal değerler üzerinde yaşanan bu çatışmaların anayasalar aracılığıyla nasıl çözümlenebileceği incelenecektir. Bunun için öncelikle siyasi kültür kavramı üzerinde durulacak; ardından, anayasalar ile siyasi kültür arasındaki ilişki, anayasalarda etno-kültürel kimliklerin tanınması temelinde incelenecektir. Buna ilişkin öğretide ileri sürülen iki temel öneri üzerinde durularak; her iki önerinin de savundukları yaklaşım ve taşıdığı riskler kısaca incelenecektir. Sonuç olarak, anayasacılık penceresinden bakıldığında, özellikle etno-kültürel tanınma taleplerinin anayasalar ile karşılanabilmesinin mümkün olup olmadığı tartışılacaktır.
Regional tourism infrastructure development in the state strategies
Authors: Petrova Mariana , Dekhtyar Nadiya , Klok Oleksii , Loseva Olha
Published: November 2018

Purposeful and reasonable state vision of the long-term tourism development strategy determines the success of a country in the world market of tourist services. Many countries have officially approved program documents that clearly outline the main goals and objectives of the state policy in the sphere of tourism, highlighting the resource potential, recreational infrastructure and preferred consumer markets, but there may be no idea of respecting the interests of domestic consumers. The maintenance of local tourism infrastructure is becoming an increasingly important prerequisite for the country’s competitiveness, as mass tourism is now replaced by individual travels. The article is aimed at studying the dependencies between the main macroeconomic indicators of the tourism industry, assessing the efficiency of foreign trade. The correlation-regression and cluster analysis has been used in order to confirm or refute the hypothesis if the effectiveness of the state support of the national tourism industry is dependent on the stable functioning of the domestic tourism market, e.g. stimulation of travels by residents. Based on the main macroeconomic indicators of the tourism industry for 136 countries of the world and overview of some national tourism development program, the analysis output has rejected the direct correlation between the support of the domestic market and export potential of the national tourism industry, but has proved the significance of the inner consumer power during the periods of downturns in the global economy for strengthening the country’s export potential.
One-year Outcome of Shanghai Mild Cognitive Impairment Cohort Study
Authors: Zhou Bin , Zhao Qianhua , Kojima Shinsuke , Ding Ding , Higashide Satoshi , Nagai Yoji , Guo Qihao , Kagimura Tatsuo , Fukushima Masanori , Hong Zhen
Published: November 2018

Background & Objective: The purpose of this study is to identify the risk factors associated with the conversion from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD) dementia for the early detection of AD.

Methods:

The study comprised a prospective cohort study that included 400 MCI subjects with annual follow-ups for 3 years.

Results:

During the first 12 months’ follow-up, 42 subjects converted to Alzheimer’s dementia (21 probable AD and 21 possible AD), two subjects converted to other types of dementia and 56 subjects lost follow. The factors associated with a greater risk of conversion from MCI to AD included gender, whole brain volume, and right hippocampal volume (rt. HV), as well as scores on the Revised Chinese version of the Alzheimer’s Disease Assessment Scale-Cognitive subscale 13 (ADAS-Cog-C), Clock Drawing Test (CDT), Symbol Digit Modalities Test (SDMT), and Rey-Osterrieth Complex Figure Test (ROCFT). The risk classification of the combined ADAS-Cog-C and Alzheimer Cognitive Composite (ACC) score with the rt. HV and left Entorhinal Cortex Volume (lt. ECV) showed a conversion difference among the groups.

Conclusion:

Early detection of AD and potential selection for clinical trial design should utilize the rt. HV, as well as neuropsychological test scores, including those of the ADAS-Cog-C and ACC.
Evolving Mechanistic Concepts of Epileptiform Synchronization and their Relevance in Curing Focal Epileptic Disorders
Authors: Lévesque Maxime , Ragsdale David , Avoli Massimo
Published: November 2018

The synchronized activity of neuronal networks under physiological conditions is mirrored by specific oscillatory patterns of the EEG that are associated with different behavioral states and cognitive functions. Excessive synchronization can, however, lead to focal epileptiform activity characterized by interictal and ictal discharges in epileptic patients and animal models. This review focusses on studies that have addressed epileptiform synchronization in temporal lobe regions by employing in vitro and in vivo recording techniques. First, we consider the role of ionotropic and metabotropic excitatory glutamatergic transmission in seizure generation as well as the paradoxical role of GABAA signaling in initiating and perhaps maintaining focal seizure activity. Second, we address non-synaptic mechanisms (which include voltage-gated ionic currents and gap junctions) in the generation of epileptiform synchronization. For each mechanism, we discuss the actions of antiepileptic drugs that are presumably modulating excitatory or inhibitory signaling and voltage-gated currents to prevent seizures in epileptic patients. These findings provide insights into the mechanisms of seizure initiation and maintenance, thus leading to the development of specific pharmacological treatments for focal epileptic disorders.
Current Drugs and Potential Future Neuroprotective Compounds for Parkinson’s Disease
Authors: Carrera Iván , Cacabelos Ramón
Published: November 2018

The research progress of understanding the etiology and pathogenesis of Parkinson's
disease (PD) has yet lead to the development of some clinical approaches intended to treat cognitive
and behavioral symptoms, such as memory and perception disorders. Despite the major advances in
different genetic causes and risk factors for PD, which share common pathways to cell dysfunction
and death, there is not yet a complete model of PD that can be used to accurately predict the effect
of drugs on disease progression. Clinical trials are also important to test any novel neuro-protective
agent, and recently there have been great advances in the use of anti-inflammatory drugs and plant
flavonoid antioxidants to protect against specific neuronal degeneration and its interference with
lipid and cholesterol metabolism. The increasing knowledge of the molecular events underlying the
degenerative process of PD has stimulated research to identify natural compounds capable of halting
or slowing the progress of neural deterioration. Polyphenols and flavonoids, which play a neuroprotective
role in a wide array of in vitro and in vivo models of neurological disorders, emerged
from among the multi-target bio-agents found mainly in plants and microorganisms. This review
presents a detailed overview of the multimodal activities of neuroprotective bio-agents tested so far,
emphasizing their neurorescue/neuroregenerative activity. The brain-penetrating property of bioagents
may make these compounds an important class of natural drugs for the treatment of neurodegenerative
diseases. Although there are numerous studies demonstrating beneficial effects in
the laboratory by identifying critical molecular targets, the clinical efficacy of these neuroprotective
treatments remains to be proven accurately.
Synthesis and Evaluation of in vitro Antiplatelet Aggregation Activities of 2-Methoxy-5-Aminobenzamides
Authors: Liu Lili , Liu Xiujie , Chen Guangling , Qiu Kai
Published: November 2018

Objective:

According to the principles of drug design, the structures of picotamide and
betrixaban were combined to design novel series of 2-methoxy-5-aminobenzamides. A total of
twenty new compounds 1a-1t have been synthesized and evaluated for their antiplatelet aggregation
activities in vitro.

Methods:

In the structural design of target compounds 1a-1t, the betrixaban was retained group
characteristics and the picotamide was retained its 1, 3, 4-substitution position. With
2-methoxybenzoic acid as starting material, compounds 1a-1t were synthesized after 5 steps of nitration,
acylation, ammoniation, reduction and secondary ammoniation. And their antiplatelet aggregation
activities in vitro were assessed by the Born test with ADP, arachidonic acid and collagen as
inducing agents, respectively, and with aspirin and picotamide as two reference drugs.

Results:

The compound 1f (46.14%±0.07) had the highest activity for ADP and its IC50 value was
0.17 µM, far better than the two control drugs aspirin (0.44 µM) and picotamide (0.47 µM). The IC50
value of four compounds 1i (0.24 µM), 1j (0.22 µM), 1r (0.25 µM) and 1t (0.24 µM), displayed
higher antiplatelet activities in vitro for AA than aspirin (0.43 µM) and picotamide (0.34 µM).
Evaluation of cytotoxicity activity of the compounds against L929 cells line revealed that at lower
concentration of 10 µmol·L-1, compound 1p had lower effect on L929 cells, and its cell survival rate
(88.24%±4.16) was higher than that (82.35%±4.16) of picotamide.

Conclusion:

Novel series of 2-methoxy-5-aminobenzamides has shown higher in vitro antiplatelet
activities and lower effect on L929 cells at lower concentration.
Exhaustive Review on Lung Cancers: Novel Technologies
Authors: Khan Sajad , Ali Shahid , Muhammad
Published: November 2018

Background:

Lung cancers or (Bronchogenic-Carcinomas) are the disease in certain parts of the lungs in which irresistible multiplication of abnormal cells leads to the inception of a tumor. Lung cancers consisting of two substantial forms based on the microscopic appearance of tumor cells are: Non-Small-Cell-Lung-Cancer (NSCLC) (80 to 85%) and Small-Cell-Lung-Cancer (SCLC) (15 to 20%).

Discussion:

Lung cancers are existing luxuriantly across the globe and the most prominent cause of death in advanced countries (USA & UK). There are many causes of lung cancers in which the utmost imperative aspect is the cigarette smoking. During the early stage, there is no perspicuous sign/symptoms but later many symptoms emerge in the infected individual such as insomnia, headache, pain, loss of appetite, fatigue, coughing etc. Lung cancers can be diagnosed in many ways, such as history, physical examination, chest X-rays and biopsy. However, after the diagnosis and confirmation of lung carcinoma, various treatment approaches are existing for curing of cancer in different stages such as surgery, radiation therapy, chemotherapy, and immune therapy. Currently, novel techniques merged that revealed advancements in detection and curing of lung cancer in which mainly includes: microarray analysis, gene expression profiling.

Conclusion:

Consequently, the purpose of the current analysis is to specify and epitomize the novel literature pertaining to the development of cancerous cells in different parts of the lung, various preeminent approaches of prevention, efficient diagnostic procedure, and treatments along with novel technologies for inhibition of cancerous cell growth in advance stages.
Phytochemical Profiling, GC-MS Analysis and α-Amylase Inhibitory Potential of Ethanolic Extract ofCocos nuciferaLinn. Endocarp
Authors: Singla Rajeev Kumar , Dubey Ashok Kumar
Published: November 2018

Background:

Drugs with post-prandial action constitute one of the main courses of treatments for diabetes.

Objective:

In the present investigation, we have explored the α-amylase inhibitory potential of ethanolic extract of Cocos nucifera endocarp.

Methods:

DNS based assay was done to assess the α-amylase inhibition potential of ethanolic extract. Phytochemical screening and GC-MS analysis were done in order to assess the chemical profiling of extract. In silico docking studies were done using VLife MDS 4.6 software and the probable molecules, predicted after GC-MS analysis, were docked with the co-crystallized (acarbose) tracked active site and rest all cavities of porcine pancreatic α-amylase (1OSE). ADMET analysis was done using StarDrop 6.4, Derek Nexus and P450 Modules from Optibrium Ltd. and LHASA Ltd.

Results:

DNS based α-amylase assay indicated that the IC50 value of extract lies in the range of 63- 126 µg/ml and at higher doses, i.e. above 250 µg/ml, it has better α-amylase inhibition than the standard drug, acarbose. Phytochemical screening indicated that ethanolic extract is rich in alkaloids, tannins, flavonoids, saponins, triterpenes, glycosides, carbohydrates, terpenoids, quinones and lactones. Further, GC-MS analysis (where Similarity Index was > 90) predicted that the probable phytoconstituents present in the ethanolic extract are myristic acid, syringaldehyde, eugenol, vanillin, 2,4-di-tert-butylphenol, lauric acid, palmitic acid methyl ester and γ-sitosterol. γ-Sitosterol showed the strong affinity towards the active site which was tracked by a co-crystallized ligand along with cavity 1 and 2 while significant interactions were observed in case of co-crystallized tracked active site as well as cavity 4 of 1OSE. Ethanolic extract of C. nucifera has no hemolytic effect.

Conclusion:

Its ability to effectively inhibit α-amylase may be attributed to the presence of the above probable molecules, which will be explored furthe
Plant-derived Glycosides with α-Glucosidase Inhibitory Activity: Current Standing and Future Prospects
Authors: Khan Haroon , Amin Surrya , Tewari Devesh , Nabavi Seyed Mohammad , Atanasov Atanas G.
Published: November 2018

Background:

The α-glucosidase (EC 3.2.1.20), a calcium-containing intestinal enzyme which is positioned in the cells which cover the intestinal microvilli brush border. The carbohydrates require metabolism by α-glucosidase before being absorbed into the small intestine, and as a result, this enzyme represents a significant drug target for the effective management of diabetes. There are few α- glucosidase inhibitors in the clinical practice that is challenged by several limitations. Thus, new effective and safe therapeutic agents in this class are required. In this regard, plant secondary metabolites are a very promising source to be investigated. Herein in this review, we have focused on the preclinical studies on various glycosides with in vitro α-glucosidase inhibitory activity.

Methods:

The literature available on various websites such as GoogleScholar, PubMed, Scopus. All the peer-reviewed articles were included without considering the impact factor.

Results:

The surveyed literature revealed marked inhibitory profile of various glycosides derived from plants, and some of them were extremely potent relatively to the standard, acarbose in preclinical trials and exhibited multiple targeted effects.

Conclusion:

Keeping in view the results, these glycosides are strong candidates for further, more detailed studies to ascertain their clinical potential and for effective contribution in effective management of diabetes, where multiple targets are required to address
The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome
Authors: Dikci Seyhan , Öztürk Emrah , Fırat Penpe G. , Yılmaz Turgut , Taşkapan Mehmet Ç. , Yoloğlu Saim
Published: November 2018

Objective: To investigate whether serum vitamin D levels have an effect on
pseudoexfoliation (PEX) glaucoma/syndrome development and on the control of glaucoma in these
cases.

Method: A total of 31 cases with PEX glaucoma, 34 cases with the PEX syndrome and 43 control
subjects of similar age and sex were included in the study. Vitamin D levels were compared between
the groups and also between the cases where glaucoma surgery was performed or not.

Results:

PEX glaucoma group consisted of 17 males and 14 females, PEX syndrome group of 27
males and 7 females, and the control group of 27 males and 16 females. The mean age was 70.9±8.9
years, 72.1±7.3 years, and 67.9±9.1 years in PEX glaucoma, syndrome and control group, respectively.
Mean vitamin D levels were 9.4±7.7 ng/mL, 7.9±6,1 ng/mL, 11.5±14.2 ng/mL in PEX glaucoma, syndrome
and control group, respectively (p>0.05). The mean serum vitamin D level was 8.04±4.7 ng/mL
in those who underwent glaucoma surgery and 10.1±8.7 ng/mL in those who didn't undergo glaucoma
surgery in PEX glaucoma group (p>0.05). No difference was found between the PEX glaucoma subgroups
in terms of the mean deviation when classified according to vitamin D levels (<10 ng/mL, ≥10
ng/mL) (p>0.05).

Conclusion:

Although we found no statistically significant difference between the PEX syndrome/
glaucoma, and control group in terms of serum vitamin D levels, serum vitamin D levels were
lower in PEX syndrome and glaucoma group than control group. Our results indicate that serum vitamin
D levels have no effect on the development of PEX glaucoma/syndrome or the control of the disorder
in cases with PEX glaucoma. However, these results need to be supported with further studies on
a larger number of patients and with longer follow-up.
The Influence of Cold Atmospheric Plasma Irradiation on the Adhesive Bond Strength in Non-Demineralized and Demineralized Human Dentin: An In Vitro Study
Authors: Imiolczyk Sandra Maria , Hertel Moritz , Hase Isabella , Paris Sebastian , Blunck Uwe , Hartwig Stefan , Preissner Saskia
Published: November 2018

Purpose:

While aiming at the use of Cold Atmospheric Plasmas (CAPs) in restorative dentistry, the present study intended to assess if plasma irradiation increases the Tensile Bond Strength (TBS) in non-demineralized and demineralized dentin.

Materials and Methods:

Forty-eight human dentin samples were assigned to three different treatment modalities: I: Plasma jet irradiation (CAP I); II: Dielectric barrier discharge plasma treatment (CAP II); and III: No plasma (control). In each group, half of the specimens had previously been demineralized. A fourth generation of adhesive and dental composite was applied to all of the samples. The testing of the TBS was performed after artificial aging.

Results:

In the non-demineralized dentin, the mean TBS values were significantly higher after using CAP II (16.95 MPa) than in the control samples (4.2 MPa; p = 0.001). Significantly higher TBS values were also obtained after irradiating the demineralized dentin with CAP I and CAP II (11.68 and 4.6 MPa) when compared to the control samples (0 MPa; p = 0.003 and 0.038). The differences between both of the plasma sources were only slightly significant (p = 0.05).

Conclusion:

CAPs can potentially enhance the adhesive/dentin interfacial bonding strength, whereby the underlying effects seem to depend on the type of plasma source and the degree of dentinal (de-) mineralization. In the non-demineralized dentin, after a complete caries excavation, dielectric barrier discharge devices might be favorable over the plasma jets, in order to improve the adhesive/dentin interfacial bonding. In contrast, the plasma jets could be more effective in the demineralized dentin after an incomplete caries excavation.
Two-axis Gimbal System Stabilization Using Adaptive Feedback Linearization
Authors: Naderolasli Amir , Tabatabaei Mohammad
Published: November 2018

Background:

This paper is devoted to adaptive feedback linearization based stabilization
of a two-axis gimbal platform.

Methods:

A Lyapunov based adaptation mechanism is proposed for stabilization of a two axes gimbal
system through a feedback linearized control structure. The uncertainty of the products of inertia
is incorporated in the design procedure.

Results:

The performed computer simulations demonstrate the robust performance of the proposed
two-axis gimbal stabilizer considering the cross-coupling effects between inner and outer gimbals.

Conclusion:

The proposed control structure could be utilized in guided missiles, spacecraft, and
navigation systems.
The two-dimensional distributed object four-point model based on correlated signals emitters
Authors: Podkopaev A. O. , Stepanov M. A. , Tyrykin S. V.
Published: November 2018

The paper considers methods for modeling fluctuations of the phase front of an electromagnetic wave reflected from a radar object (reflections) using models that emit statistically related signals. Previously, such models were considered only in relation to objects distributed over a single angular coordinate. A two-dimensional geometric model, emitting statistically related signals, was proposed for replacement of reflections from radar objects distributed over two angular coordinates. The emitters of the model are located at the vertices of the square. Expressions are obtained for determining the characteristics of signals supplied to the emitters of such model, at which the model provides the required parameters of the probability distribution density of the angular noise of the distributed object. Within the framework of the model under study, it is proved that it is possible to control the parameters of the probability density distribution of angular noise along two coordinate axes independently. The equivalence of the four-point partially coherent model and the five-point incoherent in terms of providing the probability characteristics of the angular noise is shown, and the limits of this equivalence are also determined. The proven equivalence of models allows developing an apparatus for the synthesis of spectral-correlation characteristics.
Instruments for the effective organization of production processes and their improvement during the development of radio electronics products
Authors: Mustafaev M. G.
Published: November 2018

Improvement of the quality of production processes organization, shift to a new engineering level and effective use of products are associated with the improvement of production and the development of organizational processes quality control system. The purpose of the paper is to study the methods and means that allow increasing the performance of the implementation and organization of production processes for the development of radio-electronic instrument making products, as well as their improvement. It is possible to increase production efficiency and quality of manufactured products, in particular, by ensuring the processes stability, reducing the dispersion of production parameters, timely detecting deviations of production processes and eliminating their causes. This can be achieved through the use of methods for organizing inter-operation statistical analysis, control and regulation of processes using cause-and-effect analysis of product parameters relationship, which allow establishing the statistical relationship of their parameters with the modes of the production process and patterns of product parameters distribution depending on processing factors. The analysis of converters production processes was carried out and the cause-and-effect diagram was drawn up taking into account the main factors affecting the quality and percentage of usable products yield. Structure of the analysis system for monitoring production processes and its algorithm are given. The paper shows the dependence of the filming process quality on films parameters in the form of a cause-and-effect graph, as well as products manufacture progress diagram, which demonstrates the reproducibility and stability of the converters production processes. An integrated approach to the implementation of production processes, taking into account special aspects of the technology, connection of instrument parameters with processing factors, organization processes quality control, allows reducing the dispersion of product parameters, improving process stability and overall production efficiency.
De "Lepra" à "Hanseníase": uma análise lexicológica de base sócio-histórica
Authors: Dores Marcus , Toledo Cecília
Published: November 2018

Este artigo investigou como se deu a concorrência entre as palavras lepra e hanseníase nas décadas de 1970 e 2000. A pesquisa foi realizada em quatro etapas: (1) levantamento das ocorrências das palavras lepra e hanseníase na base digital do Jornal do Brasil; (2) observação do surgimento do neologismo (hanseníase), da sua difusão e do processo de mudança na frequência de uso das palavras; (3) escolha de duas sincronias, uma antes (1970) e outra depois (2000) da inversão da frequência; (4) análise da ocorrência das palavras em 100 textos de cada sincronia. Os dados mostraram que a palavra hanseníase apareceu pela primeira vez no Jornal do Brasil em1970 – período de origem da reforma sanitária. Em 2000 – ano em que já se falava sobre a cura da doença – a palavra hanseníase ultrapassou a palavra lepra, no corpus.Os resultados alcançados revelaram que houve uma mudança de percepção social dadoença no Brasil. A palavra hanseníase surgiu em um momento de luta pelo tratamento de doenças endêmicas. Com a descoberta da cura da doença, o neologismo ganhou força e se encaixou no léxico do português. A partir desses resultados, pretendeu-se mostrar que o estudo do léxico deve considerar fatores linguísticos e sociais, como sugerido pela lexicologia sócio-histórica.
Multimodalidade e argumentação no género textual Reportagem
Authors: Leal Audria
Published: November 2018

Este artigo pretende estudar o papel do visual na argumentação do género reportagem. Para isso, analisamos dois textos deste género textual da revista portuguesa: Visão. Para esta análise, seguimos a proposta teórica da Semiótica Social, incluindo o quadro metodológico da Gramática do Design Visual. De fato, tal como indicado, o presente artigo procurará levar em consideração o papel do não-verbal no género Reportagem e em relação à função social do género. Os resultados indicam que os significados das representações visuais participam como argumentos da reportagem e são construídos a partir das práticas sociais para atender a função comunicativado género.
Representações discursivas da nação portuguesa na voz do poder. O caso das tomadas de posse de Pedro Passos Coelho e António Costa
Authors: Mercereau Jean , Costa Jorge Gomes da
Published: November 2018

O presente artigo visa analisar as práticas discursivas de representação da nação portuguesa a partir dos discursos de Tomada de Posse dos Primeiros-Ministros, Pedro Passos Coelho e António Costa (em junho de 2011 e novembro de 2015, respetivamente). Com base numa abordagem propositadamente transdisciplinar, a análise permite identificar e compreender os mecanismos usados pela voz do poder português para reforçar a sua legitimidade, impor um determinado estilo de liderança e apresentar a sua conceção ideológica da nação, através de estratégias que visam promover a adesão a esta visão, por parte do público-alvo. No final, demonstra-se que apesar do caráter distintivo da visão que cada um dos dirigentes preconiza para o futuro do país, as opções discursivas escolhidas para veicular essa visão, bem como a argumentação que sustenta os seus discursos, se aproximam grandemente, dadas as características em comum que apresentam.
Compostos de discurso direto no português do Brasil: interação fictiva no léxico
Authors: Junior José Carlos da Costa , Rocha Luiz Fernando Matos
Published: November 2018

O objetivo deste artigo é identificar, descrever e analisar os padrões formais exemplos de Compostos Nominais de Discurso Direto (CDDs) no português brasileiro, concebidos como um complexo lexical que se caracteriza por possuir um nome (N) ou sintagma nominal (SN) e um modificador em discurso direto fictivo, assim exemplificados: “aliança eu escolhi esperar”, “dia do Fico”, “boquinha de moranguinho assim me sujei com morango, sabe?’’e“maquiadoro” (adoro + maquiagem). Fundamentamos nossas reflexões com base em autores da Linguística Cognitiva, tais como Langacker (2008), Talmy (2000) e, principalmente, Pascual (2014, 2016). Apartir das 44 ocorrências de CDDs em modalidade escrita de português brasileiro, extraídas da internet, arregimentaram-se quatro padrões formais, na seguinte ordemde frequência: (i) S(N) + preposição “de” + modificador de discurso direto; (ii) (S)N + modificador de discurso direto; (iii) S(N) + (preposição “de’’) + angulador “(tipo)assim” + discurso direto; e (iv) nome + morfema de discurso direto (em uma mesma palavra). Postula-se que os CDDs sejam uma forma de mesclagem léxico-discursiva em que a adjetivação de nomes se estrutura por meio do frame de conversação, forjando dramaticidade no interior do composto, fato que promove efeitos comohumor, caricatura, crítica e persuasão.
Um 'Cartapácio' na "Gazeta de Lisboa Occidental". A "Arte Explicada" (1729-1734) de João de Morais Madureira Feijó (1688-1741)
Authors: Kemmler Rolf , Fontes Susana , Coelho Sónia , Moura Teresa , Assunção Carlos
Published: November 2018

A Orthografia, ou Arte de Escrever, e Pronunciar com acerto a Lingua Portugueza (1734) do ortógrafo setecentista Madureira Feijó é, sem dúvida, uma das obras metaortográficas mais importantes do século XVIII. No entanto, não se pode considerar uma obra independente, visto que há indícios de que ela faz parte do conjunto da obra neoalvaresiana do mesmo autor que se tornou famosa sob o título Arte Explicada. No âmbito do presente artigo, pretendemos analisar os anúncios relevantes publicados na Gazeta de Lisboa Occidental, entre 1729 e 1734, visando provar que a Orthografia de Feijó constitui a quarta e última parte da primeira edição da Arte Explicada, publicada ao longo de seis tomos na tipografia lisboeta de Miguel Rodrigues.
Joint Research Centre, European Commission
Authors: Anklam Elke
Published: November 2018

The Joint Research Centre is the Commission's science and knowledge service. The JRC employs scientists to carry out research in order to provide independent scientific advice and support to EU policy.