bluuebunny/crossref_metadata_2025 huggingface dataset:
Sensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics
Authors: Pippa Leandro Francisco , Marques Maria Paula , Silva Anna Christina Tojal da , Vilar Fernando Crivelenti , de Haes Tissiana Marques , Fonseca Benedito Antônio Lopes da , Martinez Roberto , Coelho Eduardo Barbosa , Wichert-Ana Lauro , Lanchote Vera Lucia
Published: December 2021

Neurocryptococcosis, a meningoencephalitis caused by Cryptococcus spp, is treated with amphotericin B (AmB) combined with fluconazole. The integrity of the brain-blood barrier and the composition of the cerebrospinal fluid (CSF) may change due to infectious and/or inflammatory diseases such as neurocryptococcosis allowing for the penetration of AmB into the central nervous system. The present study aimed to develop LC-MS/MS methods capable of quantifying AmB in CSF at any given time of the treatment in addition to plasma, plasma ultrafiltrate, with sensitivity compatible with the low concentrations of AmB reported in the CSF. The methods were successfully validated in the four matrices (25 μl, 5–1,000 ng ml−1 for plasma or urine; 100 μl, 0.625–250 ng ml−1 for plasma ultrafiltrate; 100 μl, 0.1–250 ng ml−1 for CSF) using protein precipitation. The methods were applied to investigate the pharmacokinetics of AmB following infusions of 100 mg every 24 h for 16 days administered as a lipid complex throughout the treatment of a neurocryptococcosis male patient. The methods allowed for a detailed description of the pharmacokinetic parameters in the assessed patient in the beginning (4th day) and end of the treatment with AmB (16th day), with total clearances of 7.21 and 4.25 L h−1, hepatic clearances of 7.15 and 4.22 L h−1, volumes of distribution of 302.94 and 206.89 L, and unbound fractions in plasma ranging from 2.26 to 3.25%. AmB was quantified in two CSF samples collected throughout the treatment with concentrations of 12.26 and 18.45 ng ml−1 on the 8th and 15th days of the treatment, respectively. The total concentration of AmB in plasma was 31 and 20 times higher than in CSF. The unbound concentration in plasma accounted for 77 and 44% of the respective concentrations in CSF. In conclusion, the present study described the most complete and sensitive method for AmB analysis in plasma, plasma ultrafiltrate, urine, and CSF applied to a clinical pharmacokinetic study following the administration of the drug as a lipid complex in one patient with neurocryptococcosis. The method can be applied to investigate the pharmacokinetics of AmB in CSF at any given time of the treatment.
Optical Characteristics and Applications of AIE Racemic C6-Unsubstituted Tetrahydropyrimidines
Authors: Zhu Qiuhua
Published: December 2021

Racemic C6-unsubstituted tetrahydropyrimidines (THPs) are the products of an efficient five-component reaction that we developed. THPs show strong AIE characteristics, that is, completely no fluorescence in different solvents but strong emission with fluorescence quantum yields (ΦF) up to 100% upon aggregation. However, the ΦF values of their pure enantiomers are lower than 46%. Unlike common AIE compounds with crowded aryl rotors on a π-bond or on an aryl ring, THPs have three completely non-crowded aryl rotors on a non-aromatic chiral central ring (tetrahydropyrimidine). In this mini review, we first discuss the AIE characteristics of THPs and the influences of molecular structures on their molecular packing modes and optical properties, and then present their applications and forecast the development of other racemic AIE compounds.
In Vitro Activity Comparison of Ceftazidime–Avibactam and Aztreonam–Avibactam Against Bloodstream Infections With Carbapenem-Resistant Organisms in China
Authors: Yu Wei , Xiong Luying , Luo Qixia , Chen Yunbo , Ji Jinru , Ying Chaoqun , Liu Zhiying , Xiao Yonghong
Published: December 2021

Objectives

The aim of this work was to investigate the activity of ceftazidime–avibactam (CZA) and aztreonam–avibactam (AZA) against bloodstream infections caused by carbapenem-resistant organisms (CROs).

Methods

Non-duplicate CROs, including 56 carbapenem-resistant Escherichia coli (CR-Eco), 318 carbapenem-resistant Klebsiella pneumoniae (CR-Kpn), and 65 carbapenem-resistant Pseudomonas aeruginosa (CR-Pae), were collected using the Blood Bacterial Resistant Investigation Collaborative System (BRICS) program in China. The minimum inhibitory concentrations (MICs) of 24 antibiotics were tested. Carbapenemase genes were amplified for CZA-resistant CROs by PCR. The MICs of CZA and AZA were further determined with avibactam at 8 and 16 mg/L, respectively.

Results

The resistance rate of polymyxin B against CROs was less than 5%. Only one CR-Kpn was resistant to tigecycline. The resistance rates of CZA against CR-Eco, CR-Kpn, and CR-Pae were 75.0%, 12.6%, and 18.5%, respectively. The MIC90 values of AZA against CR-Eco, CR-Kpn, and CR-Pae were 2/4, 1/4, and 64/4 mg/L, respectively. Among the CZA-resistant CROs, 42 (100%) CR-Eco, 24 (60%) CR-Kpn, and 1 (8.3%) CR-Pae isolates harbored metallo-β-lactamase genes. The increase of avibactam concentration enhanced the susceptibility of CZA and AZA against CROs, especially for CR-Eco and CR-Kpn.

Conclusions

The in vitro activity of AZA was superior to that of CZA against CR-Eco and CR-Kpn, whereas CZA showed better effect against CR-Pae.
Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients
Authors: Chang Shenghua , Guo Haiying , Li Jin , Ji Yaoting , Jiang Han , Ruan Lianguo , Du Minquan
Published: December 2021

Reports on alterations in the oral mycobiome of HIV-infected patients are still limited. This study was designed to compare the salivary mycobiome between 30 human immunodeficiency virus (HIV) infections and 30 healthy controls and explore the effect of antiretroviral therapy (ART) administration on the oral mycobiome of HIV infections. Results showed that the diversity and richness of salivary mycobiome in HIV-infected individuals were higher than those of controls (P < 0.05). After ART, the diversity and richness of salivary mycobiome in HIV-infected patients were reduced significantly (P < 0.05). Candida, Mortierella, Malassezia, Simplicillium, and Penicillium were significantly enriched in the HIV group and dramatically decreased after ART. While the relative abundance of Verticillium, Issatchenkia, and Alternaria significantly increased in patients with HIV after ART. Correlation analysis revealed that Mortierella, Malassezia, Simplicillium, and Chaetomium were positively correlated with viral load (VL), whereas Thyrostroma and Archaeorhizomyces were negatively related to VL and positively related to CD4+ T-cell counts. All results showed that HIV infection and ART administration affected the composition of salivary mycobiome communities. Furthermore, differences of salivary mycobiome in HIV infections after ART were complex and might mirror the immune state of the body.
Molecular Detection of Cryptosporidium spp. and Enterocytozoon bieneusi Infection in Wild Rodents From Six Provinces in China
Authors: Ni Hong-Bo , Sun Yu-Zhe , Qin Si-Yuan , Wang Yan-Chun , Zhao Quan , Sun Zheng-Yao , Zhang Miao , Yang Ding , Feng Zhi-Hui , Guan Zheng-Hao , Qiu Hong-Yu , Wang Hao-Xian , Xue Nian-Yu , Sun He-Ting
Published: December 2021

Enterocytozoon (E.) bieneusi and Cryptosporidium spp. are the most important zoonotic enteric pathogens associated with diarrheal diseases in animals and humans. However, it is still not known whether E. bieneusi and Cryptosporidium spp. are carried by wild rodents in Shanxi, Guangxi, Zhejiang, Shandong, and Inner Mongolia, China. In the present study, a total of 536 feces samples were collected from Rattus (R.) norvegicus, Mus musculus, Spermophilus (S.) dauricus, and Lasiopodomys brandti in six provinces of China, and were detected by PCR amplification of the SSU rRNA gene of Cryptosporidium spp. and ITS gene of E. bieneusi from June 2017 to November 2020. Among 536 wild rodents, 62 (11.6%) and 18 (3.4%) samples were detected as E. bieneusi- and Cryptosporidium spp.-positive, respectively. Differential prevalence rates of E. bieneusi and Cryptosporidium spp. were found in different regions. E. bieneusi was more prevalent in R. norvegicus, whereas Cryptosporidium spp. was more frequently identified in S. dauricus. Sequence analysis indicated that three known Cryptosporidium species/genotypes (Cryptosporidium viatorum, Cryptosporidium felis, and Cryptosporidium sp. rat genotype II/III) and two uncertain Cryptosporidium species (Cryptosporidium sp. novel1 and Cryptosporidium sp. novel2) were present in the investigated wild rodents. Meanwhile, 5 known E. bieneusi genotypes (XJP-II, EbpC, EbpA, D, and NCF7) and 11 novel E. bieneusi genotypes (ZJR1 to ZJR7, GXM1, HLJC1, HLJC2, and SDR1) were also observed. This is the first report for existence of E. bieneusi and Cryptosporidium spp. in wild rodents in Shanxi, Guangxi, Zhejiang, and Shandong, China. The present study also demonstrated the existence of E. bieneusi and Cryptosporidium spp. in S. dauricus worldwide for the first time. This study not only provided the basic data for the distribution of E. bieneusi and Cryptosporidium genotypes/species, but also expanded the host range of the two parasites. Moreover, the zoonotic E. bieneusi and Cryptosporidium species/genotypes were identified in the present study, suggesting wild rodents are a potential source of human infections.
Political Communication Patterns of Young Adults in Germany
Authors: Datts Mario , Wiederholz Jan-Erik , Schultze Martin , Vowe Gerhard
Published: December 2021

While the political communication and participation activities of young adults are changing, this is often not adequately captured by research due to a too narrow conceptualization of the phenomenon. Our approach conceptualizes political communication as activities comprising the reception of political content, interpersonal communication regarding political issues and political participation. We incorporated both analog and digital media, as well as different forms of political participation, to reflect the complex reality of political communication activities of young adults in the digital age. On the basis of a sample from 2013, we investigated the patterns of political communication of young adults (ages 18–33 years). This age group represents the first generation to have grown up under the ubiquitous influence of the internet and other modern information technologies. In addition, we examined factors influencing the formation of different political communication patterns of this generation. Results of cluster analyses demonstrated that young adults should not be seen as a homogeneous group. Rather, we found six communication types. Interestingly, no online-only type of political communication was revealed, By applying multinomial logistic regression analysis, we were able to demonstrate that socio-demographic variables, individual resources and cognitive involvement in politics influence the likelihood of belonging to more active political communication types. The present study investigated various information and communication opportunities of young adults, and is rare in terms of the richness of data provided. Our conceptual innovative approach enables a better understanding of young adults’ complex political communication patterns. Moreover, our approach encourages follow-up research, as our results provide a valuable starting point for intergenerational comparisons regarding changes in political engagement among young adults in Germany, as well as for cross-country analysis regarding different generations of young adults.
Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study
Authors: Charfeddine Salma , Ibn Hadj Amor Hassen , Jdidi Jihen , Torjmen Slim , Kraiem Salma , Hammami Rania , Bahloul Amine , Kallel Nesrine , Moussa Nedia , Touil Imen , Ghrab Aiman , Elghoul Jamel , Meddeb Zineb , Thabet Yamina , Kammoun Samir , Bouslama Kamel , Milouchi Sami , Abdessalem Salem , Abid Leila
Published: December 2021

The COVID-19 disease is a multisystem disease due in part to the vascular endothelium injury. Lasting effects and long-term sequelae could persist after the infection and may be due to persistent endothelial dysfunction. Our study focused on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long-covid 19 symptoms are associated with endothelial dysfunction. This is a cross-sectional multicenter observational study with prospective recruitment of patients. A total of 798 patients were included in this study. A total of 618 patients (77.4%) had long COVID-19 symptoms. The mean EQI was 2.02 ± 0.99 IC95% [1.95–2.08]. A total of 397 (49.7%) patients had impaired EQI. Fatigue, chest pain, and neuro-cognitive difficulties were significantly associated with endothelium dysfunction with an EQI <2 after adjustment for age, sex, diabetes, hypertension, dyslipidemia, coronary heart disease, and the severity of acute COVID-19 infection. In multivariate analysis, endothelial dysfunction (EQI <2), female gender, and severe clinical status at acute COVID-19 infection with a need for oxygen supplementation were independent risk factors of long COVID-19 syndrome. Long COVID-19 symptoms, specifically non-respiratory symptoms, are due to persistent endothelial dysfunction. These findings allow for better care of patients with long COVID-19 symptoms.
Effect of Health Literacy on Decision Delay in Patients With Acute Myocardial Infarction
Authors: Fan Zhao-ya , Yang Yuan , Yin Ruo-yun , Tang Lei , Zhang Fan
Published: December 2021

Background: Health literacy (HL) is a risk factor for adverse outcomes in patients with cardiovascular disease, and shorter pre-hospital delay time is crucial for successful treatment of acute myocardial infraction (AMI) patients. Most previous studies focused on the influencing factors of pre-hospital delay but ignore the essential contribution of decision delay.

Aims: Therefore, the purpose of this study was to explore the effect of HL on decision delay.

Methods: Continuously included AMI patients admitted to a grade A class three hospital in Chongqing. HL level was assessed using Brief Health Literacy Screen and categorized as adequate or inadequate. Mann-Whitney U-test and Chi-square test were used to compare the differences between groups, and binary logistic regression was used to analyze the association between HL and decision delay.

Results: A total of 217 AMI patients were enrolled in this study, including 166 males (76.5%) and 51 females (23.5%), with the median age was 68 years old; 135 (62.2%) patients had delayed decision-making while 82 (37.8%) did not; 157 (72.7%) patients had inadequate HL and 59 (27.3%) had adequate HL. The total HL score of non-delayed group was higher than that in delayed group (9.22 vs. 7.02, P < 0.000).

Conclusion: After adjusting for covariates, HL was significantly negatively associated with decision time. AMI patients with inadequate HL were more likely to delay seeking timely medical care.
Right Ventricular Diastolic Performance in Patients With Chronic Thromboembolic Pulmonary Hypertension Assessed by Echocardiography
Authors: Meng Hong , Song Wu , Liu Sheng , Hsi David , Wan Lin-Yuan , Li Hui , Zheng Shan-shan , Wang Zhi-wei , Ren Rong , Yang Wei-xian
Published: December 2021

Background: There have been no systemic studies about right heart filling pressure and right ventricular (RV) distensibility in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Therefore, we aimed to explore combinations of echocardiographic indices to assess the stages of RV diastolic dysfunction.

Methods and Results: We recruited 32 healthy volunteers and 71 patients with CTEPH. All participants underwent echocardiography, cardiac catheterization (in patients with CTEPH), and a 6-min walk test (6MWT). The right atrial (RA) end-systolic area was adjusted for body surface area (BSA) (indexed RA area). RV global longitudinal diastolic strain rates (SRs) and RV ejection fraction (EF) were measured by speckle tracking and three-dimensional echocardiography (3D echo), respectively. All 71 patients with CTEPH underwent pulmonary endarterectomy. Of the 71 patients, 52 (73%) had decreased RV systolic function; 12 (16.9%), 26 (36.6%), and 33 (46.5%) patients had normal RV diastolic pattern, abnormal relaxation (stage 1), and pseudo-normal patterns (stage 2), respectively. The receiver operating characteristic curve analysis showed that the optimal cut-off values of early diastolic SR <0.8 s−1 and indexed RA area > 8.8 cm2/BSA had the best accuracy in identifying patients with RV diastolic dysfunction, with 87% sensitivity and 82% specificity. During a mean follow-up of 25.2 months after pulmonary endarterectomy, the preoperative indexed RA area was shown as an independent risk factor of the decreased 6MWT distance.

Conclusions: Measuring early diastolic SR and indexed RA area would be useful in stratifying RV diastolic function.
Dynamic Handgrip Exercise: Feasibility and Physiologic Stress Response of a Potential Needle-Free Cardiac Magnetic Resonance Stress Test
Authors: Ochs Andreas , Nippes Michael , Salatzki Janek , Weberling Lukas D. , Riffel Johannes , Müller-Hennessen Matthias , Giannitsis Evangelos , Osman Nael , Stehning Christian , André Florian , Katus Hugo A. , Frey Norbert , Friedrich Matthias G. , Ochs Marco M.
Published: December 2021

Background: Cardiac magnetic resonance (CMR) pharmacological stress-testing is a well-established technique for detecting myocardial ischemia. Although stressors and contrast agents seem relatively safe, contraindications and side effects must be considered. Substantial costs are further limiting its applicability. Dynamic handgrip exercise (DHE) may have the potential to address these shortcomings as a physiological stressor. We therefore evaluated the feasibility and physiologic stress response of DHE in relation to pharmacological dobutamine-stimulation within the context of CMR examinations.

Methods: Two groups were prospectively enrolled: (I) volunteers without relevant disease and (II) patients with known CAD referred for stress-testing. A both-handed, metronome-guided DHE was performed over 2 min continuously with 80 contractions/minute by all participants, whereas dobutamine stress-testing was only performed in group (II). Short axis strain by fast-Strain-ENCoded imaging was acquired at rest, immediately after DHE and during dobutamine infusion.

Results: Eighty middle-aged individuals (age 56 ± 17 years, 48 men) were enrolled. DHE triggered significant positive chronotropic (HRrest: 68 ± 10 bpm, HRDHE: 91 ± 13 bpm, p < 0.001) and inotropic stress response (GLSrest: −19.4 ± 1.9%, GLSDHE: −20.6 ± 2.1%, p < 0.001). Exercise-induced increase of longitudinal strain was present in healthy volunteers and patients with CAD to the same extent, but in general more pronounced in the midventricular and apical layers (p < 0.01). DHE was aborted by a minor portion (7%) due to peripheral fatigue. The inotropic effect of DHE appears to be non-inferior to intermediate dobutamine-stimulation (GLSDHE= −19.5 ± 2.3%, GLSDob= −19.1 ± 3.1%, p = n.s.), whereas its chronotropic effect was superior (HRDHE= 89 ± 14 bpm, HRDob= 78 ± 15 bpm, p < 0.001).

Conclusions: DHE causes positive ino- and chronotropic effects superior to intermediate dobutamine-stimulation, suggesting a relevant increase of myocardial oxygen demand. DHE appears to be safe and timesaving with broad applicability. The data encourages further studies to determine its potential to detect obstructive CAD.
Association Between Dynamic Change of QT Interval and Long-Term Cardiovascular Outcomes: A Prospective Cohort Study
Authors: Ye Min , Zhang Jing-Wei , Liu Jia , Zhang Ming , Yao Feng-Juan , Cheng Yun-Jiu
Published: December 2021

Background: The prolongation or shortening of heart rate-corrected QT (QTc) predisposes patients to fatal ventricular arrhythmias and sudden cardiac death (SCD), but the association of dynamic change of QTc interval with mortality in the general population remains unclear.

Methods: A total of 11,798 middle-aged subjects from the prospective, population-based cohort were included in this analysis. The QTc interval corrected for heart rate was measured on two occasions around 3 years apart in the Atherosclerosis Risk in Communities (ARIC) study. The ΔQTc interval was calculated by evaluating a change in QTc interval from visit 1 to visit 2.

Results: After a median follow-up of 19.5 years, the association between the dynamic change of QTc interval and endpoints of death was U-shaped. The multivariate-adjusted hazard ratios (HRs) comparing subjects above the 95th percentile of Framingham–corrected ΔQTc (ΔQTcF) (≥32 ms) with subjects in the middle quintile (0–8 ms) were 2.69 (95% CI, 1.68–4.30) for SCD, 2.51 (1.68–3.74) for coronary heart disease death, 2.10 (1.50–2.94) for cardiovascular death, and 1.30 (1.11–1.55) for death from any cause. The corresponding HRs comparing subjects with a ΔQTcF below the fifth percentile (<-23 ms) with those in the middle quintile were 1.82 (1.09–3.05) for SCD, 1.83 (1.19–2.81) for coronary heart disease death, 2.14 (1.51–2.96) for cardiovascular death, and 1.31 (1.11–1.56) for death from any cause. Less extreme deviations of ΔQTcF were also associated with an increased risk of death. Similar, albeit weaker associations also were observed with ΔQTc corrected with Bazett's formula.

Conclusions: A dynamic change of QTc interval is associated with increased mortality risk in the general population, indicating that repeated measurements of the QTc interval may be available to provide additional prognostic information.
Prognostic Significance of Feature-Tracking Right Ventricular Global Longitudinal Strain in Non-ischemic Dilated Cardiomyopathy
Authors: Cittar Marco , Cipriani Alberto , Merlo Marco , Vitrella Giancarlo , Masè Marco , Carrer Anna , Barbati Giulia , Belgrano Manuel , Pagnan Lorenzo , De Lazzari Manuel , Giorgi Benedetta , Cova Maria A. , Iliceto Sabino , Basso Cristina , Stolfo Davide , Sinagra Gianfranco , Perazzolo Marra Martina
Published: December 2021

Aims: Left ventricular global longitudinal strain (GLS) by cardiac magnetic resonance feature tracking (CMR-FT) analysis has shown an incremental prognostic value compared to classical parameters in non-ischemic dilated cardiomyopathy (NICM). However, less is known about the role of right ventricular (RV) GLS. Our objective was to evaluate the prognostic impact of RV-GLS by CMR-FT analysis in a population of NICM patients.

Methods: In this multicenter study, we examined NICM patients evaluated with a comprehensive CMR-FT study. Major cardiac events (MACEs) were considered as the study primary outcome measure and were defined as a composite of (a) cardiovascular death, (b) cardiac transplant or destination therapy ventricular assist device, (c) hospitalization for life-threatening ventricular arrhythmias or implantable cardiac defibrillator appropriate intervention. Heart failure (HF) related events, including hospitalizations and life-threatening arrhythmia-related events were considered as secondary end-points. Receiver operating time-dependent analysis were used to calculate the possible additional effect of RV-GLS to standard evaluation.

Results: We consecutively enrolled 273 patients. During a median follow-up of 39 months, 41 patients (15%) experienced MACEs. RV-GLS and LV late gadolinium emerged as the strongest prognostic CMR-FT variables: their association provided an estimated 3-year MACEs rate of 29%. The addition of RV-GLS significantly improved the prognostic accuracy in predicting MACEs with respect to the standard evaluation including LGE (areas under the curve from 0.71 [0.66–0.82] to 0.76 [0.66–0.86], p = 0.03). On competing risk analysis, RV-GLS showed a significant ability to reclassify overall both HF-related and life-threatening arrhythmia-related events, regardless of LV and RV ejection fraction.

Conclusions: In NICM patients, RV-GLS showed a significant prognostic role in reclassifying the risk of MACEs, incremental with respect to standard evaluation with standard prognostic parameters.
Atrial Fibrillation Ablation Using Robotic Magnetic Navigation Reduces the Incidence of Silent Cerebral Embolism
Authors: Zheng Jie , Wang Meng , Tang Qun-feng , Xue Feng , Li Ku-lin , Dang Shi-peng , Liu Xiao-yu , Zhao Xiao-xi , Zhang Chang-ying , Yu Zhi-ming , Han Bing , Jiang Ting-bo , Yao Yan , Wang Ru-Xing
Published: December 2021

Background: The incidence of silent cerebral embolisms (SCEs) has been documented after pulmonary vein isolation using different ablation technologies; however, it is unreported in patients undergoing with atrial fibrillation (AF) ablation using Robotic Magnetic Navigation (RMN). The purpose of this prospective study was to investigate the incidence, risk predictors and probable mechanisms of SCEs in patients with AF ablation and the potential impact of RMN on SCE rates.

Methods and Results: We performed a prospective study of 166 patients with paroxysmal or persistent AF who underwent pulmonary vein isolation. Patients were divided into RMN group (n = 104) and manual control (MC) group (n = 62), and analyzed for their demographic, medical, echocardiographic, and risk predictors of SCEs. All patients underwent cerebral magnetic resonance imaging within 48 h before and after the ablation procedure to assess cerebral embolism. The incidence and potential risk factors of SCEs were compared between the two groups. There were 26 total cases of SCEs in this study, including 6 cases in the RMN group and 20 cases in the MC group. The incidences of SCEs in the RMN group and the MC group were 5.77 and 32.26%, respectively (X2 = 20.63 P < 0.05). Univariate logistic regression analysis demonstrated that ablation technology, CHA2DS2-VASc score, history of cerebrovascular accident/transient ischemic attack, and low ejection fraction were significantly associated with SCEs, and multivariate logistic regression analysis showed that MC ablation was the only independent risk factor of SCEs after an AF ablation procedure.

Conclusions: Ablation technology, CHA2DS2-VASc score, history of cerebrovascular accident/transient ischemic attack, and low ejection fraction are associated with SCEs. However, ablation technology is the only independent risk factor of SCEs and RMN can significantly reduce the incidence of SCEs resulting from AF ablation.

Clinical Trial Registration: ChiCTR2100046505.
Fast GPU-Based Generation of Large Graph Networks From Degree Distributions
Authors: Alam Maksudul , Perumalla Kalyan
Published: December 2021

Synthetically generated, large graph networks serve as useful proxies to real-world networks for many graph-based applications. The ability to generate such networks helps overcome several limitations of real-world networks regarding their number, availability, and access. Here, we present the design, implementation, and performance study of a novel network generator that can produce very large graph networks conforming to any desired degree distribution. The generator is designed and implemented for efficient execution on modern graphics processing units (GPUs). Given an array of desired vertex degrees and number of vertices for each desired degree, our algorithm generates the edges of a random graph that satisfies the input degree distribution. Multiple runtime variants are implemented and tested: 1) a uniform static work assignment using a fixed thread launch scheme, 2) a load-balanced static work assignment also with fixed thread launch but with cost-aware task-to-thread mapping, and 3) a dynamic scheme with multiple GPU kernels asynchronously launched from the CPU. The generation is tested on a range of popular networks such as Twitter and Facebook, representing different scales and skews in degree distributions. Results show that, using our algorithm on a single modern GPU (NVIDIA Volta V100), it is possible to generate large-scale graph networks at rates exceeding 50 billion edges per second for a 69 billion-edge network. GPU profiling confirms high utilization and low branching divergence of our implementation from small to large network sizes. For networks with scattered distributions, we provide a coarsening method that further increases the GPU-based generation speed by up to a factor of 4 on tested input networks with over 45 billion edges.
Knowledge-infused Learning for Entity Prediction in Driving Scenes
Authors: Wickramarachchi Ruwan , Henson Cory , Sheth Amit
Published: December 2021

Scene understanding is a key technical challenge within the autonomous driving domain. It requires a deep semantic understanding of the entities and relations found within complex physical and social environments that is both accurate and complete. In practice, this can be accomplished by representing entities in a scene and their relations as a knowledge graph (KG). This scene knowledge graph may then be utilized for the task of entity prediction, leading to improved scene understanding. In this paper, we will define and formalize this problem as Knowledge-based Entity Prediction (KEP). KEP aims to improve scene understanding by predicting potentially unrecognized entities by leveraging heterogeneous, high-level semantic knowledge of driving scenes. An innovative neuro-symbolic solution for KEP is presented, based on knowledge-infused learning, which 1) introduces a dataset agnostic ontology to describe driving scenes, 2) uses an expressive, holistic representation of scenes with knowledge graphs, and 3) proposes an effective, non-standard mapping of the KEP problem to the problem of link prediction (LP) using knowledge-graph embeddings (KGE). Using real, complex and high-quality data from urban driving scenes, we demonstrate its effectiveness by showing that the missing entities may be predicted with high precision (0.87 Hits@1) while significantly outperforming the non-semantic/rule-based baselines.
Wind Speed Forecasting in Fishing Harbor Anchorage Using a Novel Deep Convolutional Neural Network
Authors: He Caifen , Chen Qiaote , Fang Xuyuan , Zhou Yangzhang , Fu Randi , Jin Wei
Published: December 2021

Wind speed forecasting is an important issue in Marine fisheries. Improving the accuracy of wind speed forecasting is helpful to reduce the loss of fishery economy caused by strong wind. This paper proposes a wind speed forecasting method for fishing harbor anchorage based on a novel deep convolutional neural network. By combining the actual monitoring data of the automatic weather station with the numerical weather prediction (NWP) products, the proposed method constructing a deep convolutional neural network was based wind speed forecasting model. The model includes a one-dimensional convolution module (1D-CM) and a two-dimensional convolution module (2D-CM), in which 1D-CM extracts the time series features of the meteorological data, and 2D-CM is used to mine the latent semantic information from the outputs of 1D-CM. In order to alleviate the overfitting problem of the model, the L2 regularization and the dropout strategies are adopted in the training process, which improves the generalization of the model with higher reliability for wind speed prediction. Simulation experiments were carried out, using the 2016 wind speed and related meteorological data of a sheltered anchorage in Xiangshan, Ningbo, China. The results showed that, for wind speed forecast in the next 1 h, the proposed method outperform the traditional methods in terms of prediction accuracy; the mean absolute error (MAE) and the mean absolute percentage error (MAPE) of the proposed method are 0.3945 m/s and 5.71%, respectively.
Characterization of Full Pore and Stress Compression Response of Reservoirs With Different Coal Ranks
Authors: Lu Jielin , Fu Xuehai , Kang Junqiang , Cheng Ming , Wang Zhenzhi
Published: December 2021

The accurate characterization of coal pore structure is significant for coalbed methane (CBM) development. The splicing of practical pore ranges of multiple test methods can reflect pore structure characteristics. The pore\fracture compressibility is the main parameter affecting the porosity and permeability of coal reservoirs. The difference in compressibility of different coal rank reservoirs and pore\fracture structures with changing stress have not been systematically found. The pore structure characteristics of different rank coal samples were characterized using the optimal pore ranges of high-pressure mercury intrusion (HPMI), low-temperature liquid nitrogen adsorption (LT-N2A), low-pressure carbon dioxide adsorption (LP-CDA), and nuclear magnetic resonance (NMR) based on six groups of different rank coal samples. The compressibility of coal matrix and pore\fracture were studied using HPMI data and NMR T2 spectrum under effective stress. The results show that the more accurate full pore characterization results can be obtained by selecting the optimal pore range measured by HPMI, LT-N2A, and LP-CDA and comparing it with the NMR pore results. The matrix compressibility of different rank coal samples shows that low-rank coal > high-rank coal > medium-rank coal. When the effective stress is less than 6 MPa, the microfractures are compressed rapidly, and the compressibility decreases slowly when the effective stress is more than 6 MPa. Thus, the compressibility of the adsorption pore is weak. Nevertheless, the adsorption pore has the most significant compression space because of the largest proportion in different pore structures. The variation trend of matrix compressibility and pore\fracture compressibility is consistent with the increase of coal rank. The compressibility decreases with the rise of reservoir heterogeneity and mechanical strength. The development of pore volume promotes compressibility. The research results have guiding significance for the exploration and development of CBM in different coal rank reservoirs.
Mechanical Properties of a Typical Jurassic Shaximiao Sandstone Under Subzero and Deep in situ Temperature Conditions
Authors: He R. , He L. , Guan B. , Yuan C. M. , Xie J. , Ren L.
Published: December 2021

Insight into the difference between the mechanical properties of rocks at low and in situ deep reservoir temperatures is vital for achieving a better understanding of fracking technologies with supercritical CO2 and liquid nitrogen. To address this issue, the fracking-related mechanical properties of the Shaximiao Formation sandstone (SS) were investigated through direct tension, uniaxial compression, and three-point bending fracture tests at a typical low temperature (Tlow) of −10°C and a reservoir temperature (Tin situ) of 70°C. The results showed that the tensile strength σt, compressive strength σc, and fracture toughness KIC of the SS were all higher at Tlow than at Tin situ, although to different extents. The KIC of the SS increased slightly more than σt at the lower temperature, while both σt and KIC of the SS increased significantly more than σc at the lower temperature. In addition to the strength, the stiffness (particularly the tensile stiffness) and the brittleness indices of SS were similarly higher at Tlow than at Tin situ. In situ monitoring using the digital image correlation technique revealed that a highly strained band (HSB) always appeared at the crack front. However, because of the inhomogeneous microstructure of the SS, the HSB did not always develop along the line connecting the notch tip to the loading point. This was a possible cause of the highly dispersed KIC values of the SS. The HSB at the crack front was notably narrower at Tlow than at Tin situ, suggesting that low temperatures suppress the plastic deformation of rocks and are therefore beneficial to reservoir stimulation.
Decreasing Influence of Summer Snow Cover Over the Western Tibetan Plateau on East Asian Precipitation Under Global Warming
Authors: Wang Zhibiao , Wu Renguang , Chen Zhang , Zhu Lihua , Yang Kai , Liu Kui , Yang Yiya
Published: December 2021

In recent years, some studies emphasized the influence of western Tibetan Plateau summer snow on the East Asian summer precipitation. With the temperature rise in the past decades, the snow cover over the western Tibetan Plateau in summer has significantly decreased. This raises the question whether the impact of the Tibetan Plateau snow has changed. The present study identifies a prominent change in the influence of the western Tibetan Plateau snow cover on the East Asian summer precipitation. Before the early 2000’s, positive precipitation anomalies extend from the southeastern Tibetan Plateau through the Yangtze River to Japan and Korea and negative anomalies cover southeast China corresponding to more Tibetan Plateau snow cover. After the early 2000’s, with the reduction of snow cover variability, below-normal and above-normal summer precipitation occurs over northern China-Mongolia and northeast Asia, respectively, corresponding to more Tibetan Plateau snow cover. The change in the influence of the Tibetan Plateau snow on the East Asian summer precipitation is associated with an obvious change in the atmospheric circulation anomaly pattern. Before the early 2000’s, the wind anomalies display a south-north contrast pattern with anomalous convergence along the Yangtze River. After the early 2000’s, an anomalous cyclone occupies Northeast China with anomalous southerlies and northerlies over northeast Asia and northern China, respectively. The Tibetan Plateau snow cover variation after the early 2000’s is associated with the northeast Indian summer precipitation. The model experiments confirm that the weakened influence of summer western Tibetan Plateau snow cover on the East Asian atmospheric circulation and precipitation with the reduced snow cover anomalies.
Study on Dynamic Characteristics of Drill String Considering Rock-Breaking Process
Authors: Liang Deyang , Guan Zhichuan , Xu Yuqiang , Liu Yongwang
Published: December 2021

Using various tools to obtain downhole data to reach a precise pore pressure model is an important means to predict overpressure. Most downhole tools are connected to the lower end of drill string and move with it. It is necessary to understand the motion state and dynamic characteristics of drill string, which will affect the use of downhole tools. In this paper, a drilling process considering rock-breaking process in vertical wells is simulated using finite element method. In the simulation, gravity is applied to the whole drill string. The contact force between PDC bit and formation is the weight on bit (WOB). And a rotation speed is applied to the upper end of drill string. Analysis of the results shows that the vibration amplitude of bottom hole WOB (contact force between PDC bit and formation, which is the real WOB in drilling process) is bigger than the amplitude of wellhead WOB (acquired through conversion using Hook load, which is on behalf of the WOB obtained on drilling site). Both wellhead WOB and bottom hole WOB decline with a fluctuation in drilling process. In small initial WOB and low rotation speed conditions, the fluctuation of wellhead WOB focuses on low frequency, the fluctuation of bottom hole WOB focus on high frequency, and the phase of them are not identical. In large initial WOB and high rotation speed conditions, the fluctuation of wellhead WOB and bottom hole WOB both become more irregular. As for wellhead torque and bottom hole torque, the fluctuation of them mainly focuses on low frequency. And in high rotation speed conditions, wellhead torque may become negative. The research results are beneficial to the usage of downhole tools.
Primary School Teachers’ Perception of Low Functioning Students: Validation of the EPREPADI-1 Scale
Authors: Santa María Yonatan Díaz , Saorín Jesús Molina
Published: December 2021

This research contributes to the knowledge and understanding of some aspects of the professional practice of primary education teachers in the Region of Murcia (Spain), and its possible effect on the creation of situations of educational exclusion. For this purpose, an instrument called EPREPADI-1 (Scale of Perception of Primary Education Teachers on their Training and Professional Practice in relation to Pupils with Disabilities) has been developed. The design and structure of the instrument includes important aspects that seek to highlight teachers’ views and knowledge of educational legislation (international, national and regional), their views on nomenclatures (such as those of persons with disabilities and inclusive education), as well as their assessment of the use of language of denial in relation to pupils with lower functional performance. Furthermore, after the statistical tests carried out for the validation of the scale (Kendall’s W test and Cronbach’s Alpha), values were obtained that give the instrument excellent validity and reliability (both for the group of experts and also for the pilot group), which is why its use and application is recommended.
RETRACTED: Effect of Weekly Long-Acting Growth Hormone Replacement Therapy Compared to Daily Growth Hormone on Children With Short Stature: A Meta-Analysis
Authors: Ma Liyan , Li Liangyi , Pan Wen , Huang Congfu , Liu Limei , Zhang Xiaoxiao
Published: December 2021

Background

We performed a meta-analysis to evaluate the efficacy and safety of weekly long-acting growth hormone replacement therapy compared to daily growth hormone in children with short stature.

Methods

A systematic literature search up to April 2021 was performed and 11 studies included 1,232 children with short stature treated with growth hormone replacement therapy at the start of the study; 737 of them were using weekly long-acting growth hormone replacement therapy and 495 were using daily growth hormone. They were reporting relationships between the efficacy and safety of long-acting growth hormone replacement therapy and daily growth hormone in children with short stature. We calculated the odds ratio (OR), and mean difference (MD) with 95% confidence intervals (CIs) to assess the efficacy and safety of weekly long-acting growth hormone replacement therapy compared to daily growth hormone in children with short stature using the dichotomous or continuous method with a random or fixed-effect model.

Results

Long-acting growth hormone replacement therapy had significantly lower height standard deviation scores chronological age (MD, −0.10; 95% CI, −0.13 to −0.08, p <0.001), and insulin-like growth factor binding protein-3 (MD, −0.69; 95% CI, −1.09 to −0.30, p <0.001) compared to daily growth hormone in children with short stature.

However, growth hormone replacement therapy had no significantly difference in height velocity (MD, −0.09; 95% CI, −0.69–0.5, p = 0.76), height standard deviation scores bone age (MD, −0.04; 95% CI, −0.10–0.02, p = 0.16), insulin-like growth factor 1 standard deviation scores (MD, 0.26; 95% CI, −0.26–0.79, p = 0.33), and incidence of adverse events (OR, 1.16; 95% CI, 0.90–1.50, p = 0.25) compared to daily growth hormone in children with short stature.

Conclusions

Long-acting growth hormone replacement therapy had significantly lower height standard deviation scores chronological age, and insulin-like growth factor binding protein-3 compared to daily growth hormone in children with short stature. However, growth hormone replacement therapy had no significant difference in height velocity, height standard deviation scores bone age, insulin-like growth factor 1 standard deviation scores, and incidence of adverse events compared to daily growth hormone in children with short stature. Further studies are required to validate these findings.
The Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review
Authors: Chen Wen-Chieh , Luo Sheng-Dean , Chen Wei-Chih , Chou Chen-Kai , Chang Yen-Hsiang , Cheng Kai-Lun , Lin Wei-Che
Published: December 2021

Background

Nodule rupture is a relatively uncommon yet severe complication of radiofrequency ablation (RFA). When nodule rupture occurs, determining suitable therapeutic management is a critical issue. A study herein aimed to identify the predictive factors affecting the management of post-RFA nodule rupture.

Methods

Post-RFA nodule rupture data of 9 patients were enrolled from 2 medical centers. A literature investigation was performed, uncovering nodule rupture data of 17 patients. A total of 26 patients were analyzed and divided into two groups, categorized as patients requiring either invasive or conservative therapeutic management. Data including initial symptoms, imaging, therapeutic management, and prognosis were reviewed and compared between the two groups.

Results

Significant differences in nodule diameter, and the ablation time of the course prior to rupture (RUP time) were noted between the two groups (p = 0.045 and 0.008, respectively). Logistic regression analysis indicated the initial nodule diameter and RUP time significantly affected the requirement of invasive treatment (OR 1.99 and 1.11, respectively). Considering practicality, when a nodule with an initial maximum diameter of >4.5cm ruptured, invasive management was suggested (sensitivity 69% and specificity 79%).

Conclusion

Though nodule ruptures can be managed conservatively, a ruptured nodule with an initial maximum diameter of >4.5cm may require invasive management. Understanding the significant clinical and imaging features will help physicians make an appropriate risk assessment to determine the correct treatment in a timely manner.
Diabetes Care in French Guiana: The Gap Between National Guidelines and Reality
Authors: Sudre Christine , Duplan Hélène , Bukasakakamba John , Nacher Mathieu , Peyre-Costa Pascale , Sabbah Nadia
Published: December 2021

Introduction

French Guiana is a multicultural overseas territory in the Amazon, where precariousness and difficulties in access to care are widespread. The prevalence of diabetes is double that of other French departments, and cardiovascular morbidity and mortality is high. The objective of the study was to analyze the biological, clinical and therapeutic follow-up of patients with diabetes mellitus using exhaustive data and to correlate it with national and European recommendations.

Material and Methods

Using the national health insurance data, 9079 and 10075 patients with diabetes mellitus were analyzed in 2018 and 2019, respectively. We analyzed antidiabetic treatments, medical, dental, and podiatric consultations, examinations prescribed as part of the annual follow-up, and home nursing care.

Results

There was a significant increase over one year in the number of patients (+10%) with diabetes, mainly women (60%), and 31% were under 54 years of age, with a disparity depending on the area of the territory, the most isolated having less access to screening. Less than 56% of patients had HbA1c measurements twice a year, less than 43% had an annual renal check-up, only 19% had an ophthalmic check-up at least every two years, less than 25% had an annual dental check-up, and less than 4% had an annual follow-up with the podiatrist.

Conclusions

Substandard diabetes monitoring is a major problem likely to increase morbidity and mortality. Adapting health care to the specificities of the territory is crucial, notably by formalizing the delegation of care to advanced practice nurse and non-healthcare professionals in precarious or geographically isolated areas.