bluuebunny/crossref_metadata_2025 huggingface dataset:
AS CRIANÇAS PEQUENAS SOB UMA BOA GUARDA
Authors: Plaisance Eric
Published: June 2023

As limitações profissionais e de tempo dos pais, as possibilidades institucionais e sociais na guarda e no cuidado das crianças pequenas levaram os sociólogos a redefinir as “idades” da pequena infância: 0-2 anos, a creche; 2-3 anos, o “jardin d’éveil”; a partir dos três anos, a escola maternal, à qual devemos acrescentar a guarda em casa e, para as classes mais ricas, a empregada doméstica. A partir de entrevistas com pais, E. Plaisance mostra que os interessados ressaltam a liberdade de escolha (mesmo quando as ofertas são raras) e reforçam o tom da evidência de que a solução tomada era a melhor para eles e para a criança. Mas as respostas mostram também que eles buscam se informar, segundo meios que favorecem o “boca a boca” e que dão lugar aos fenômenos do rumor. De fato, a “escolha” dos atores é determinada, mas como para se tranquilizar e assumir sua responsabilidade, eles a descrevem voluntariamente como “livre”.Palavras-chave: Guarda e educação de crianças pequenas; Escolha dos pais; Transmissão de rumores (boca a boca).Veja também a versão original em francês publicada nesta edição.LES JEUNES ENFANTS SOUS BONNE GARDELes contraintes horaires et professionnelles des parents, les possibilités institutionnelles et sociales dans la garde et la prise en charge des jeunes enfants, ont amené les sociologues à redéfinir les “âges” de la petite enfance : 0-2 ans, la crèche ; 2-3 ans, le “jardin d’éveil”; à partir de 3 ans, l’école maternelle, à quoi il faut ajouter la garde à domicile et pour les classes les plus aisées l’employée de maison. À partir d’entretiens avec les parents, É. Plaisance montre que les intéressés mettent en avant le libre choix (même quant les offres sont rares) et soulignent sur le ton de l’évidence que la solution retenue était la meilleure pour eux-mêmes et pour l’enfant. Mais les réponses montrent aussi qu’ils cherchent à se renseigner, selon des modes qui favorisent le bouche à oreille et laissent place aux phénomènes de rumeur. De fait, le “choix” des acteurs est déterminé, mais comme pour se rassurer et assumer leur responsabilité, ils le décrivent volontiers comme “libre”.Mots-clés: Garde et éducation des jeunes enfants; Choix des parents; Enquête par interviews ; Transmission des rumeurs (bouche à oreille).Voir aussi la version originale française publiée dans ce numéro.
A violência nas escolas brasileiras: reflexões a partir dos dados do Saeb 2013 e 2017
Authors: Marinho Iasmin da Costa , Vidal Eloisa Maia , Vieira Sofia Lerche
Published: June 2023

O artigo objetiva investigar a violência na escola considerando duas formas propostas por Charlot (2002): a violência na escola e a violência à escola, a partir dos microdados obtidos nos questionários contextuais do Sistema de Avaliação da Educação Básica aplicados aos diretores e aos professores das escolas em que são realizadas as avaliações de desempenho escolar junto a alunos de 5º e 9º anos do ensino fundamental e 3ª série do ensino médio, nos anos de 2013 e 2017. Os dados foram trabalhados em planilha de Excel e tratados com uso de estatística descritiva e gráficos com valores relativos. A revisão de literatura procurou identificar como a violência no ambiente escolar vem sendo tratada e os fatores explicativos sobre o fenômeno e suas múltiplas dimensões. Os dados mostram que, em todas as redes escolares, registram-se atos de violência, sendo as redes públicas de ensino municipais e estaduais as que apresentam maiores incidências, o que pode estar associado a variáveis geográficas, bem como ao perfil familiar, nível socioeconômico e faixa etária dos estudantes. Os dados revelam também que os diretores percebem as diversas formas de violência nas escolas de modo mais intenso do que os docentes, situação que pode ter relação com as suas respectivas funções no ambiente escolar. O estudo conclui que a violência na escola não pode nem deve ser vista de forma isolada de outras dimensões da política educacional, uma vez que sua presença é causa de uma cadeia de efeitos sobre todos os sujeitos do processo educativo.
Resolução de problemas no ensino de matemática: reflexões sobre o conhecimento de pedagogos
Authors: Leonardo Maria Eliza Sitolino , Proença Marcelo Carlos
Published: June 2023

Este artigo tem como objetivo analisar o conhecimento de professores dos anos iniciais do ensino fundamental sobre a resolução de problemas no ensino de matemática. Participaram da pesquisa nove professores pedagogos dos anos iniciais do ensino fundamental da rede municipal de ensino de Teodoro Sampaio/SP. A pesquisa é exploratória e de natureza qualitativa. Os dados foram coletados por meio de um questionário e entrevista semiestruturada aplicados aos participantes da pesquisa. O questionário procurou investigar como os professores utilizam a resolução de problemas em suas aulas, e, na entrevista, foram apresentadas aulas com resolução de problemas para que o professor justificasse sua escolha em uma das abordagens apresentadas, a saber: ensino para resolução de problemas; ensino sobre resolução de problemas e ensino via resolução de problemas. Os resultados mostraram que, muitas vezes, os professores apresentam dificuldades em compreender a resolução de problemas no ensino e que ainda acreditam que o conteúdo deve ser ensinado, para então, depois, serem aplicados problemas a serem resolvidos. Conclui-se que são relevantes mais pesquisas que abordem a utilização da resolução de problemas no ensino, bem como abordem a oferta de formação continuada de professores para tratar da resolução de problemas no ensino de matemática.
Laicidade brasileira na perspectiva da colonialidade do poder
Authors: Dantas Adriana Santiado Rosa , Abuhab Valente Gabriela
Published: June 2023

O conceito de laicidade utilizado por grande parte de estudiosos brasileiros tem fundamentação teórica na matriz francesa. Contudo, questiona-se neste artigo a adoção do conceito como universal para a estrutura social brasileira. A partir de um estudo empírico comparativo que permitiu a realização de 18 entrevistas com professores brasileiros e 18 com professores franceses sobre os entendimentos do conceito de laicidade foi possível constatar uma percepção distinta por parte dos docentes dos dois países. Essa diferença está presente na forma como os professores compreendem e mobilizam este conceito. Questionou-se o que representaria tal distinção para além das diferenças culturais, tendo como hipótese as diferenças estruturais, justificando, assim, a necessidade de rediscussão do conceito de laicidade no Brasil. Perguntou-se que tipo de laicidade existe neste país? Para responder este questionamento, buscamos analisar os dados da pesquisa empírica a partir da perspectiva teórica decolonial da colonialidade/modernidade. Concluiu-se que o conceito de laicidade francês não pode ser importado para o Brasil tal qual, pois sua construção na França se fez a partir da separação entre Estado e religião, remetendo ao projeto político de construção de consenso social da nação moderna. Por outro lado, no Brasil, a aliança entre Estado e religião era necessária para a formação do consenso nacional de uma estrutura social racializada.
LETTER TO THE READER
Authors: Reali Aline Maria de Medeiros Rodrigues , Abramowicz Anete , Passos Cármen Lúcia Brancaglion , Onofre Elenice Maria Cammarosano , Lima Emilia Freitas de , Silva Júnior João dos Reis , Tagliavini João Virgilio
Published: June 2023

Letter do the Reader
Impact of Mycobacterium Avium subspecies Paratuberculosis (MAP) on Crhon’s disease and Effective Nursing Care
Authors: Uiyeol Yoon , Burrell Patricia
Published: June 2023

Crohn's disease is a chronic inflammatory disease and is also an autoimmune disease (CDC, 2021; Johns Hopkins Medicine; NIH; Hinkle & Cheever, 2017). However, recent studies have found that John's Disease (JD) occurring in animals is very similar to Crohn's Disease (CD) appearing in humans. The Mycobacterium avium subsp Paratuberculosis (MAP) bacteria that causes JD has drawn recent attention (McNees et al, 2015; Pierce, 2010). Many studies have revealed that MAP bacteria have been found in many Crohn's disease patients and it’s suspected that MAP bacteria may be the main cause of Crohn's disease. Crohn's disease nursing strategies are emerging that consider MAP bacterial infection (Rosenfeld & Bressler, 2010; Crohn's MAP Vaccine; Momotani et al., 2012). A recent study notes that various immunosuppressant medication treatments present with documented significant adverse effects that include but are not limited to dependency on steroids and hypersensitivity (Alcedo et al., 2016; Hinkle & Cheever, 2017). In most cases, patients need surgical intervention, including various abdominal surgeries such as laparoscopic surgery (Alcedo et al., 2016). These surgical procedures require the patient high cost, time consuming for recovery, and change their lifestyle, especially when the CD recurs (Alcedo et al., 2016). This study explores nutrition, patient education for self-management, nursing interventions, and lab results in order to provide better nursing care for Crohn's disease patients with focus on MAP bacterial infection. This study looks at possible patient's nutritional limitations with the consideration of MAP bacterial infection with the evidence of lab indicators and nursing interventions including patient isolation, patient education for self-care and adherence to continuous medication, based on the immunosuppressants the patient receives.
Die Umweltpolitik von Rechtsaußenparteien in Europa
Authors: Biskamp Floris
Published: June 2023

Auch wenn die umweltpolitischen Positionen europäischer Rechtsaußenparteien nicht einheitlich sind, lässt sich doch eine grobe Tendenz erkennen: Zumeist verteidigen sie fossile Lebensformen und positionieren sich gegen jeden Versuch ambitionierter Klimapolitik, dem Schutz der natürlichen Umwelt im nationalen Rahmen stehen sie dagegen offen gegenüber. Damit konnten sie in den letzten Jahren auch Einfluss auf politische Polarisierungsdynamiken und Regierungshandeln erlangen.
Wie die Neue Rechte versucht, Einfluss auf die deutsche Postwachstumsbewegung zu nehmen
Authors: Passeick Yannick
Published: June 2023

Kapitalismuskritik und Naturschutzbestrebungen innerhalb des Postwachstumsdiskurses sind für die Neue Rechte historisch anschlussfähig. Welche Argumentationslinien sind hier besonders naheliegend und welche Schlussfolgerungen ergeben sich daraus für eine emanzipatorische Postwachstumstheorie?
Planungskonflikte und Partizipation: die Gigafactory Tesla
Authors: Kühn Manfred
Published: June 2023

Conflicts are considered as vital elements of plural democracies in agonistic political and planning theory. According to this theory, antagonisms are to be tamed and channeled into agonistic disputes. Therefore, forms of participation in planning procedures play a key role in the resolution and regulation of conflicts. The central question of this paper is the role of participatory procedures in planning in order to resolve and settle conflicts, which occur in a particularly sharp way in the context of large-scale projects. The paper presents planning conflicts and forms of participation using the case of the settlement of the Gigafactory Tesla in the German state of Brandenburg. Within the framework of an empirical case study, the approval procedure of the project and a land use plan procedure of the municipality are analysed. Both procedures are characterized by a great acceleration, early preliminary decisions and participation deficits. The result shows that in the case of the settlement of Tesla, in addition to conflicts of interest, values and location, procedural conflicts also occur, which call the acceptance of planning into question. The forms of participation practiced do not prove suitable for taming conflicts, but rather produce mistrust among opponents and reinforce antagonistic dynamics.
Soara Batak: The Batak People's Resistance Newspaper in the Colonial Period (1919-1932)
Authors: Azhari Ichwan
Published: June 2023

Newspapers have a very important position in the politics of the Indonesian independence movement. Soara Batak is the first independence movement newspaper published in Batakland. This newspaper became a medium of information and communication, for the political organization Hatopan Kristen Batak (HKB). The initial purpose of publishing this newspaper was to oppose Dutch colonialism and the threat of foreign plantation entrepreneurs who wanted to capitalize on Batakland for personal gain. This can be seen from the motto of this newspaper which is written: Oela tanom, Oelang digomak Oelando which means “Cultivate your land, so that the Dutch do not take it”. This newspaper's courage in criticizing the colonial rulers caused Soara Batak's movements to be closely monitored. Tuan M. H. Manullang and A. Soetan Soemoroeng, the dual HKB and Soara Batak received repressive measures from the colonial government for their bold and sharp writings. The presence of Soara Batak had an important role in the politics of the Batak people's movement, which succeeded in igniting the people's fighting spirit to want to oppose Dutch colonialism which was very oppressive.
Bringing constructed languages back to the debate: The contributions of interlinguistics to general linguistics
Authors: Fians Guilherme
Published: June 2023

In the first half of the twentieth century, the fields of interlinguistics and Esperanto studies emerged as branches of linguistics focused on the study of languages designed for international communication (such as Volapük, Esperanto, and Ido). Yet, why are there specific fields to study language creation and why should linguists care about this? Looking at the history of constructed languages, this article explores the institutionalization of interlinguistics by focusing on the history of the Centre for Research and Documentation on World Language Problems (CED, in its Esperanto acronym), a research center founded in 1952 whose developments encapsulate certain aspects of this broader narrative. From an analysis of CED’s 44th Esperanto Studies Conference, in 2022, I flesh out the potential of interlinguistics to contribute back to linguistics and to the humanities disciplines that originated it. Ultimately, this article calls for the reinsertion of constructed languages into general linguistics debates.
RETURN SPILLOVERS BETWEEN EMERGING MARKETS’ FINANCIAL STRESS AND EQUITY MARKETS OF BRIC-T COUNTRIES
Authors: GÜNAY Samet
Published: June 2023

This study explores the connectedness between selected emerging equity markets (BRIC-T) and the

Emerging Markets Financial Stress Index (EMFSI). We aim to reveal the extent of spillovers from stock

market indices to aggregated financial tension in these countries. Empirical investigations are executed

through Quantile Vector Autoregression analysis. Results show that spillovers occur mainly during extreme

negative and positive return periods. When we focus on four important phases, namely Global Financial

Crisis (GFC), the Euro Area Sovereign Debt Crisis, the COVID-19 pandemic, and the Russia-Ukraine war,

three countries come to the fore. While Brazil has had a substantial and persistent impact across the years,

during the GFC, two other countries, Russia and Türkiye, seem to induce positive return spillovers toward

emerging markets’ stress. This impact becomes bilateral in Russia (both in positive and negative returns)

during the pandemic and the Russia-Ukraine war. Thus, we conclude that among the examined market

economies, negative or positive return transmissions to emerging market stress are led mainly by Brazil and

Russia. The importance of energy sources and political factors can account for this result.
The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study
Authors: Sjöstrand Sandra , Widerström Alice , Svensson Ingrid , Segers Patrick , Erlöv Tobias , Ahlgren Åsa Rydén , Cinthio Magnus
Published: June 2023

Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Further, we have identified that a tapered geometry and the intramural friction in‐between two parts of a vessel wall influence the longitudinal displacement. We therefore studied the interaction between pressure, vessel geometry and intramural friction, tapered and straight ultrasound phantoms in a paralleled hydraulic bench study and corresponding numerical models. Profound antegrade longitudinal motion was induced in the innermost part of both tapered phantoms and the numerical models, but to a lesser extent when intramural friction was increased in the simulations. Strong correlations (R = 0.82–0.96;p < 1e‐3;k = 9.3–14 μm/mmHg) between longitudinal displacement and pulse pressure were found in six of seven regions of interest in tapered phantoms. The motion of the straight phantom and the corresponding numerical model was smaller, on average zero or close to zero. This study demonstrates that tapering of the lumen, low intramural friction, and pressure might be important conducive features to the antegrade longitudinal motion of the arterial wall in vivo.
Thermodynamics and micellization behavior of choline based ionic liquids in presence of drug Cetrizine dihydrochloride
Authors: Sharma Pooja , Kaur Jasmeet , Kaur Ramanjeet , Kumar Harsh , Kaur Gagandeep
Published: June 2023

Ionic liquids (IL) have attained immense interest as substitutes for conventionally available surfactants because of their exceptionally favorable physicochemical properties. Most synthesized IL surfactants are not environmentally benign, and even utilizing high concentration, they form unstable micelles. In this regard, we have synthesized biocompatible and halogen free choline based ionic liquids by varying anions (choline oleate and cholinium bis(2-ethylhexyl) sulfosuccinate) and further investigated their micellization behavior in presence of the drug Cetrizine dihydrochloride. Characterizations of these synthesized ionic liquids were performed utilizing 1HNMR spectroscopy. The thermodynamic investigation and determination of various surface-active parameters were based on tensiometry and conductometric titrations. The CMC value of choline oleate ([CHO][Ole]) was found to be lower than that of [Cho][AOT] and thus it has a better surface activity. The thermodynamic parameters (

Δ
G

m
0

${{\Delta}G}_{m}^{0}$

,

Δ
H

m
0

${{\Delta}H}_{m}^{0}$

, and

Δ
S

m
0

${{\Delta}S}_{m}^{0}$

) signifies spontaneous, stable, exothermic and entropy driven nature of micellization process. The various interfacial and surface parameters have been evaluated employing tensiometry. These environmentally friendly ionic liquids have been utilized as substitute for conventional surfactants including their applications in biology and pharmaceutical industries.
Effect of relativistic ponderomotive force on shock waves in a relativistic degenerate plasma
Authors: Abrar Hamza , Noureen Syeda , Aziz Farah
Published: June 2023

We investigate the effect of relativistic ponderomotive force on the propagation of shock waves in relativistic degenerate plasma, which is relevant to high-intensity laser-plasma experiments aimed at replicating extreme conditions on white dwarfs. We derive the KdV-Burger’s equation by incorporating the density modification induced by the ponderomotive force and hence demonstrate that this equation is a suitable model for shock waves affected by ponderomotive force. Unlike previous studies that use ponderomotive force as a source of nonlinearity to derive the nonlinear Schrödinger equation for envelope solitons, our study focuses on the effect of ponderomotive force on shocks produced by the intense laser. We show that the ponderomotive force can significantly modify the strength and shape of shock waves, providing insight into the underlying physics of shock waves in relativistic degenerate plasmas which may help to better understand experimental observations in this regime.
GLOBĖJŲ Į(SI)GALINIMO RAIŠKA SAVITARPIO PAGALBOS GRUPĖJE
Authors: Dirgėlienė Indrė , Rimkevičiūtė Aistė , Ramūnė Šukytė-Arutiunian
Published: June 2023

The childcare system in Lithuania is going through extensive changes in order to ensure the preparation and assessment of people who want to care for or adopt a child, on-call guardians have appeared, care centres have started operating in all municipalities, a unified agreement of guardians (carers), on-call guardians, adoptive parents and community children has been approved, as has the GIMK training and counselling programme for nursing home workers. Individuals who want to become a child’s guardian are trained and evaluated, and mutual support groups have started being organised. This is one of the measures aimed at strengthening, supporting and providing assistance to guardians (care givers), and there is an opportunity to solve issues relating to child custody. There are more and more guardians (care givers) who face difficulties in communicating with the ward, their relationship is strained, and the child experiences learning and adaptation difficulties, as a result of which the guardianship process is becoming more and more complicated. The current problem is manifestations of non-constructive behaviour that arise in adolescence, which worsen if these problems are not solved. A frequent guardian (carer) turns to care centre specialists, social workers and psychologists for help. Children’s guardians (carers) need constant qualified assistance from specialists and the state, because only in this way can guardians properly and competently perform their duty and meet the child’s needs and interests. This article analyses the experience of a mutual support group for care givers, and presents a qualitative study. The results of the study confirm the effectiveness of this type of support, and allow us to predict and design other support measures for care givers.
RPV Embrittlement Assessment—Spain
Authors: Ballesteros Antonio , Colomer Marta , Serrano Marta
Published: June 2023

This paper gives an overview of the embrittlement evaluation carried out in Spain as part of the RPV surveillance programs. Special emphasis is given to the use of embrittlement trend curves and their use for structural integrity assessment. The paper also covers other important aspects, such as international research projects with relevant contributions from Spanish organizations and the monitoring of neutron fluence facing long-term operation.
Development and Status of the Embrittlement Trend Curve in Japan
Authors: Hashimoto Yoshinori , Nomoto Akiyoshi , Saeki Ryoichi , Nakashima Kenichi , Nishida Kenji , Kirk Mark
Published: June 2023

This paper gives the development status of the embrittlement trend curve (ETC) in Japan. The current Japanese ETC for neutron-irradiated reactor pressure vessel steels, which is standardized by Japan Electric Association Code (JEAC) 4201-2007 (2013 addendum), was developed on the basis of Japanese surveillance and material test reactor data. To improve the accuracy with which the ETC predicts microstructure formation by neutron irradiation, we also used the atom probe tomography data for the ETC revision described in this paper. The revised ETC model (C40 model) has a simple functional form and, unlike the current version of JEAC4201, does not require numerical time integration. The C40 model has a similar transition temperature shift ΔT41J prediction performance as the current JEAC4201 model and better microstructure formation prediction performance than the current JEAC4201 model. To improve user convenience, we reduced the number of coefficients in the C40 model, obtaining a modified ETC with 20 calibration coefficients (C20 model) that has similar accuracy as the original ETC. The C20 model is being considered as a candidate for the next JEAC4201 ETC. The revision work on JEAC4201 is ongoing within the Japan Electric Association.
History and Development of U.S. NRC Regulatory Guide 1.99
Authors: Widrevitz Daniel S. , Poehler Jeffrey C.
Published: June 2023

An overview is provided detailing the basis and evolution of U.S. Nuclear Regulatory Commission (NRC) Regulatory Guide 1.99 from initial publication to the current second revision. This regulatory guide concerns the prediction of reactor vessel aging effects due to neutron irradiation, including effects on RTNDT and upper-shelf energy. The core of this regulatory guide is an embrittlement trend curve supporting the prediction of material properties in relation to the material chemistry and neutron fluence received. The results of the 2019 U.S. NRC assessment of the regulatory guide are then presented. Finally, we discuss preliminary work supporting potential alternatives to the embrittlement trend curve present in the current revision of the regulatory guide.
Evaluation of the ASTM E900 ΔT41J Prediction Equation in Light of New Data
Authors: Kirk Mark , Blanco Diego Ferreño , Sainz-Aja Guerra Jose Adolfo
Published: June 2023

Predicting the future embrittlement state of operating nuclear power reactors is a critical part of their safe life management. Guidance on this topic traditionally comes from various sources, including ASTM standards such as ASTM E900, Standard Guide for Predicting Radiation-Induced Transition Temperature Shift in Reactor Vessel Materials. This paper summarizes ongoing efforts within ASTM to evaluate the Charpy transition temperature shift (ΔT41J) equation contained within ASTM E900-15 in light of the 195 new data records made available since the 2015 update. A simple statistical analysis of how well the trends in these data conform to the E900-15 predictions was performed as well as a more comprehensive bootstrap evaluation to ensure that our conclusions are robust across sample size and not a consequence of the particular 195 newly available records. Both evaluations demonstrated that, especially for the variables nickel and manganese, a statistically significant variation exists between the available data and E900-15 ΔT41J predictions. However, the bootstrap analysis demonstrated that these discrepancies in how E900-15 represents certain variable trends may be approximately offsetting, and, in any event, are less than the ΔT41J measurement error. Thus, although these results suggest that a better embrittlement trend curve (ETC) than E900-15 exists in principle, they also demonstrate that the continued use of E900-15 is not expected to produce errors in ΔT41J predictions of any practical significance. Therefore, we believe that there is no pressing need to update the E900-15 ETC.
Effects of Prior Hardening on Irradiation Embrittlement Predictions
Authors: Erickson Marjorie , Kirk Mark
Published: June 2023

Defect density (prior hardening) plays a large role in determining how much energy is absorbed by a material via dislocation motion prior to fracture. High point and line defect densities reduce dislocation mobility and thus the energy absorbed to fracture, resulting in lower measures of fracture toughness (KJc or JIc). For any given material, there is a maximum load condition (defined as dσ/dɛ = σ) that coincides with the engineering ultimate tensile stress at which deformation transitions from bulk movement of dislocations to local growth of voids or cracks. This suggests that there is a maximum defect density that can be accumulated in a material prior to the onset of fracture and that any measure of energy absorbed to fracture (e.g., Charpy or fracture toughness) will saturate as hardening increases. The idea of a maximum defect density implied by the maximum load condition suggests that the unirradiated defect density should be accounted for when trying to predict the effects of irradiation on subsequent measures of irradiated toughness. Unirradiated yield strength provides one possibility to account for initial defect density (prior hardening) on the effects of subsequent irradiation hardening. Tensile, Charpy, and fracture toughness data are used to investigate this prior hardening idea.
PATTERN OF MMP2 AND MMP9 EXPRESSION DEPENDS ON BREAST CANCER PATIENTS’ AGE
Authors: Lukianova N. , Mushii O. , Borikun T. , Zadvornyi T. , Bazas V. , Krotevych M. , Sivak L. , Lyalkin S. , Martynyuk О. , Hrybach S. , Chekhun V.
Published: June 2023

Background: Despite the large number of studies devoted to the study of the features of tumor microenvironment in breast cancer (BCa), presently there is no consensus on the features of MMP-2 and MMP-9 expression in the tumor tissue of BCa patients depending on the age. The aim of the study was to investigate the relationship between MMP-2 and -9 expression at the protein and mRNA levels in BCa tissues and the clinical and pathological features of BCapatientsin different age groups. Materials and Methods: The expression level of MMP-2 and -9in the BCa tissue of patients of two age groups (< 45 years and > 45 years) was studied using the bioinformatics method (UALCAN database), immunohistochemical method, and real-time PCR. Results: It was established that a characteristic feature of BCa in young patients is the low level of MMP2 mRNA against the background of increased expression of this gelatinase at the protein level, as well as decreased expression of MMP9 at both the mRNA and protein levels. When analyzing the correlation of the gelatinase expression indices in BCa tissue of young patients, depending on the clinical and pathological features, a significantly lower level of MMP-2 expression was recorded in BCa cases of stage II compared to the indices of stage I cases. High expression of MMP-2 and -9 was recorded in BCa tissue in node-positive cases and the basal molecular BCa subtype. Conclusions: The identified relationship between the expression of the studied gelatinases and such indices of BCa malignancy as its stage, positive regional lymph node status, and the molecular BCa subtype in young patients indicates the need for further research of the features of the tumor microenvironment to predict the cancer aggressiveness.
NEW DATA ON HISTOGENESIS AND HISTOLOGICAL STRUCTURE OF LUNG CANCER
Authors: Bolgova L. , Shypko A. , Tuganova T. , Alekseenko O. , Smolanka I. , Ponomarenko A. , Bilko N.
Published: June 2023

Background: Lung cancer (LC) is one of the most common malignant neoplasms in men around the world, which poses a number of important challenges for scientists. Aim: To analyze the histogenesis, features of the histological structure, and growth of LC. Materials and Methods. The surgical material of 81 patients with LC was studied. Histological preparations were stained with hematoxylin and eosin (H&E) using the Papanicolaou method. Immunohistochemical reactions with monoclonals (Ki67, PCNA) were conducted. Results: In histological preparations of all LC types (squamous, adenocarcinoma, and small cell), along with solid growth, tumor growth in the alveoli was determined, which started from the basal membrane and grew toward the alveolus center, as evidenced by the morphological features of growth, tumor spread, and development of necrosis in the center. Conclusion: In all the studied histological preparations of LC, tumor growth in the alveoli is noted, which is confirmed by structural and cellular signs and the nature of tumor decay in the alveolus center, which corresponds to the general patterns of development of malignant epithelial tumors.
FAMILIAL NON-MEDULLARY THYROID CARCINOMA
Authors: Guda B.B. , Komisarenko I.I. , Ostafiichuk M.V. , Tronko M.D.
Published: June 2023

Background:Familial non-medullary thyroid carcinoma (FNMTC) is defined as cancer developing in two or more first-degree relatives if predisposing factors, for example, radiation, are absent. The disease can be either syndromic, when it is a component of complex genetic syndromes, or non-syndromic (95% cases). The genetic basis of non-syndromic FNMTC is unknown; the clinical behavior of tumorsis unclear and, at times, contradictory.Aim: To analyze clinical manifestations of FNMTC and compare them with the data for sporadic papillary thyroid carcinomas in patients of the same age groups. Materials and Methods:We examined 22 patients (a “parents” group and a “children” group) suffering from the non-syndromic FNMTC. For comparison, two groups of sporadic papillary carcinomas patients of the same age were drawn up(“adult” and “young”). We analyzed tumor size and frequency of the distributionby the categoryof TNM system, invasiveness, multifocality, metastases to lymph nodes, type and extent of surgical and radioiodine treatment, and prognosis according to the MACIS criterion. Results:Whether sporadic or familial, the tumor size, metastatic potential, and invasive potential are higher in young people, asalready known. There was no significant difference between the “parents” and “adult” groups of patients in terms of tumor parameters. One exception was the higher frequency of multifocal tumors in the FNMTC patients. Meanwhile, compared to the “young” sporadic papillary carcinomas patients, the FNMTC “children” had a higher frequency of T2 tumors, metastasizing (N1a–N1ab), and multifocal tumors, but a lower frequency of carcinomas with intrathyroidal invasions.In the FNMTC “children” compared to FNMTC “parents” was a higher frequency of T2 tumors, metastasizing carcinomas, and tumors with capsular invasion. Conclusion:FNMTC carcinomas are more aggressive than sporadic ones, especially in patients who are first-degree relatives in a family with parents already diagnosed with the disease.
EXPRESSION OF ALU REPEAT IN BLOOD PLASMA OF PATIENTS WITH BREAST CANCER DURING NEOADJUVANT CHEMOTHERAPY: AN EXPLORATORY STUDY
Authors: Özgür E. , Ferhatoglu F. , Sen F. , Saip P. , Gezer U.
Published: June 2023

Background:Locally advanced breast cancer (LABC) rates are unusually high in developing countries. There is a need for the identification of predictive biomarkers for the selection of patients who could benefit from neoadjuvant chemotherapy (NAC). Aim: As the expression of ALU repeat is increased in cancer and has not been assessed in liquid biopsy of cancer patients, our goal was to assess ALU expression in the blood plasma of LABC patients during NAC. Patients and Methods:Plasma samples drawn at baseline and at the end of the fourth cycle of chemotherapy were used to determine the plasma levels of ALU-RNA by quantitative real-time PCR. Results: ALU expression from baseline to the fourth cycle of NAC increased from a median relative level of 1870 to 3370 in the whole group (p = 0.03). The increase in ALU-RNA levels in the course of NAC was more pronounced in premenopausal women and in patients with hormone-positive tumors. In patients with complete response to NAC, baseline ALU expression was higher than that in those with partial response. Conclusion: This exploratory study provides evidence that plasma ALU-RNA levels are modulated by the menopausal status and hormone receptor status of breast cancer patients and pre-therapeutic ALU-RNA levels might be useful in predicting the response to chemotherapy in a neoadjuvant setting.
Spanish Translation of a Parent-Reported Hospital-to-Home Transition Experience Measure
Authors: Squires Stephanie S. , Lion K. Casey , Burgara Jacqueline , Garcia Yesenia , Desai Arti D.
Published: June 2023

OBJECTIVES

A critical focus of pediatric hospital systems is to improve the quality of hospital-to-home transitions. Although validated patient-reported measures evaluating these improvement efforts exist for English-speaking families, a comprehensive measure to assess transition quality among families who speak a language other than English does not yet exist.

METHODS

We used a team consensus translation approach to translate and culturally adapt the previously validated Pediatric Transition Experience Measure (P-TEM), a caregiver-reported hospital-to-home transition quality measure, from English to Spanish. We describe our rigorous translation approach, which involved a series of steps to preserve the original meaning of the P-TEM through careful team-based linguistic and cultural adaptation of the measure into Spanish. During this process, we also found additional opportunities to improve the understandability and content validity of the original English version of P-TEM. We then pilot tested the new Spanish P-TEM with 36 parents and administered the revised English P-TEM with 125 caregivers (ie, parents/legal guardians).

RESULTS

In pilot testing, none of the Spanish-speaking parents reported difficulty understanding questions, though 6% (2/36) expressed difficulty with understanding the response scale, prompting a change to present clearer scale anchors. Mean scores on the Spanish P-TEM were 95.4 (SD, 9.6) for the total score. Mean scores on the revised English P-TEM were 88.6 (SD, 15.6; total).

CONCLUSIONS

Using a team consensus translation approach is a comprehensive and collaborative approach that allows for translation of measures originally developed for English-speaking families to be translated in a way that is reliable, accurate, and culturally appropriate.
On the structure of groups admitting faithful modules with certain conditions of primitivity
Authors: Tushev A.V.
Published: June 2023

In the paper we study structure of soluble-by-finite groups of finite torsion-free rank which admit faithful modules with conditions of primitivity. In particular, we prove that under some additional conditions if an infinite finitely generated linear group $G$ of finite rank admits a fully primitive fully faithful module then $G$ has infinite $FC$-centre.
Специфіка фахової підготовки журналістів ділових медіа в Україні
Authors: Nikytenko Viktoriia
Published: June 2023

У статті комплексно досліджено підходи до підготовки фахівців у діловій та економічній журналістиці у вітчизняних та закордонних навчальних закладах. Авторка, опрацювавши підходи до організації навчання вузькопрофільних журналістів у практиці західних вишів та беручи до уваги вітчизняні реалії, зокрема відсутність освітньо-професійних програм підготовки ділових журналістів, а також стан і перспективи ділового медіаландшафту та запит профільної спільноти, розробила фахові компетентності та програмні результати навчання як елементи освітньо-професійної програми для подальшої інституалізації школи ділової журналістики в Україні. Описані в статті підходи до організації робочого процесу були враховані при розробці робочої програми з навчальної дисципліни «Бізнес-журналістика: медіапрактикум» для студентів 2 курсу освітньо-професійної програми «Економічна журналістика» Київського національного університету імені Вадима Гетьмана. У статті також наведено ряд ключових понять і термінів із термінологічного словника ділової журналістики, укладеного авторкою в межах дисертаційного дослідження. Запропоновано визначення понять: «ділова журналістика», «діловий журналіст», «галузеві стандарти ділової журналістики», «профіль ділового журналіста», «професійні компетенції ділового журналіста», «рівень занурення ділового журналіста в контекст», які до цього не були термінологізовані в науковому середовищі. Результати дослідження можуть бути використані при розробці освітніх програм підготовки ділових журналістів з урахуванням практикоорієнтованого підходу, а також для удосконалення навчальних курсів із економічної та ділової проблематики в межах фахової підготовки студентів-журналістів, зокрема щодо особливостей роботи з вузькогалузевою інформацією, соціально-економічними темами.
Яким бачиться “нейрокопірайтинг” читачам посібника Дениса Каплунова
Authors: Mykhaylova Alla
Published: June 2023

Рецензія на посібник: Каплунов Д. Нейрокопірайтінг. — Харків : Фабула, 2018. — 352 с.
Central Gaulish samian ware in Pannonia
Authors: Gabler Dénes
Published: June 2023

In Pannonia from 122 sites 9867 Central Gaulish samian are recorded so far. The greatest number of this pottery has been published from the towns adjacent legionary fortress. Central Gaulish pottery is usually rare to find in cemeteries. The quantity of this ware everywhere greater than that of South Gaulish samian.

90.66% of the Central Gaulish terra sigillata are from Lezoux and 7.6% of this ware can be related to the workshops of Les Martres de Veyre. There may also have been a small number of Central Gaulish sigillata imported from Vichy, Terre Franche, Toulon sur Allier or Lubie. These samall production centres could be considered as possibilities.

The Lezoux group is represented in Pannonia by 15 plain and 2 decorated forms. The decorated ware can be chronologically divided into three large groups. The earliest ware of Trajanic period is quite rare in Pannonia; they occur only in the western part of the province.

The second chronological group, the Hadrianic–early Antonine one is in Pannonia a total of five times larger, than the Trajanic group. The total number of the third group, the Antonine samian is seven times larger, than the number of Hadrianic–early Antonine sigillata.

Hadrian founded 8 to 9 municipiums in Pannonia. The new cities, mainly the two provinial seats Carnuntum and Aquincum had a large shipment of ware from Central Gaul. After the Marcomannic wars (166–180 AD) Rheinzabern took over a leading role on the provincial markets.
The Roman and late antique site of Montessoro (Isola del Cantone – Genova): A case study of the wattle and daub construction technique
Authors: de Vingo Paolo , Bruna Andrea , Parodi Giovanni Battista
Published: June 2023

Archaeological excavations at the site of Montessoro (660 m. a.sl.), carried out between 2009 and 2013 by the Department of Christian and Medieval Archaeology (University of Turin – Department of the Historical Studies) and currently under publication, have led to the large-scale exploration of a rural Apennine site which was inhabited between the first century BC and the fifth century AD. The late antique phase, which is the best-preserved, consists of five farm buildings made using a masonry base bound with clay, with an elevation in lathwork and a roof made of cover and pan tiles. The systematic study of almost 600 clay fragments, some of them large and mainly from the collapse levels caused by the fire in the granary, with negative impressions of plant material, has enabled considerable information to be obtained about the technique of wattle and daub used to construct the elevations: the morphology and arrangement of the wooden parts (horizontal and vertical), related to the woven lattice of the lathwork and the load-bearing structure, and the mixing and application of clay and plaster. This work, associated with a thorough analysis of the plentiful wood charcoal remains (carried out by Prof. Lanfredo Castelletti and Dr. Sila Motella – Museo Civico P. Giovio di Como), has yielded data about the choice and working of the plants and trees used for the construction of elevations and all the structural parts, enabling a fairly precise reconstruction of the buildings and the socio-economic and cultural context of the site.
Places of worship from the Ottoman Period in Timișoara, Romania
Authors: Gașpar Adriana
Published: June 2023

This paper deals with Muslim places of worship and their evolution during the 164 years of Ottoman rule in Timișoara (1552–1716). The analysis was carried out on the basis of written historical documentation and archaeological results. It is about religious structures such as mosques (câmii) and other places of worship (mescid), but also about monastic centres of dervishes (tekke, zâviye and türbe). The archaeological research that took place in the last decade in Timișoara offered the chance to bring to light the foundations of three mosques: Ali Bey, Cimcime and Sultan Süleyman. The results of these researches are valuable, especially since no building in Timișoara dating from the Ottoman Period has survived. From an archaeological point of view, it was found that only two of the mosques share similar characteristics. Although at all three of them wooden posts were found at the bottom of the foundation ditch, beaten into the ground, the differences were in the techniques of the foundation construction. At two of the foundation walls, was discovered a reinforcement of wooden beams, fixed with iron nails, over which a mixture of mortar with stone and broken brick was placed. At the third foundation wall, a similar mixture was framed by a row of bricks laid on the edge of the foundation ditch. Moreover, two of the mosques were built according to a rectangular plan, and in the third plan the north side was closed with an apse. Archaeological research also indicated a possible minaret, mihrab, but also parts of the floor of one of the mosques.
A “Centaur” in Music and Genre: G. F. Handel's Parnasso in festa for Princess Anne's Wedding
Authors: Zsovár Judit
Published: June 2023

Parnasso in festa (HWV 73, 1734), George Frideric Handel's festa teatrale, composed for the wedding festivities of his royal pupil Princess Anne, is a neglected piece within his oeuvre, mostly because of its hybrid nature. The fact that a considerable portion of the work was adapted from the Oxford oratorio Athalia ought not to cloud our appreciation of the newly-composed parts, since this appropriation is best understood as an act of Athalia's “repatriation” to its patrons. As a musical “centaur,” Parnasso shows intriguing multi-layered ambiguities. Was the Janus-faced Handel (Apollo/Orpheus) lamenting the departure of his favorite, or was this a bitter-sweet celebration of an unwanted marriage? Dramatically, the focus falls on Apollo's and Orpheus's loss of their loved ones, but how does this fit together with the massive vocal domain of Carestini (Apollo) and Strada (Clio)? On the vocal side, Carestini was given the most virtuosic numbers, resulting in the musical polarization of the main roles. Anna Maria Strada, as a Muse, represented the pastoral side, while Carlo Scalzi (Orfeo) added plaintive pathetic arias to the palette. Nevertheless, harmonizing points both in Carestini's and Strada's musical style and vocal tone formed a “thread” that helped sew the diverse parts of the Parnasso-centaur together.
Polyphonies and Affinities: Ştefan Niculescu and György Ligeti
Authors: Sandu-Dediu Valentina
Published: June 2023

I propose an overview of some of the defining aspects of Ștefan Niculescu's composition, some of which link him to his much better known contemporary on the world stage, György Ligeti. The musical affinities between the two have evolved into a steadfast friendship, reflected in a newly published correspondence that is becoming significant for slices of recent music history. I do not intend a comparison or an analytical parallel between the compositions of the two: the focus will fall on Niculescu's musical springs, with some signs of his and Ligeti's compatibility. Niculescu's heterophony versus Ligeti's micropolyphony, the impulses both received from mathematics, linguistics, the natural sciences, as well as the search (since the 1980s) for a new diatonicism that would configure an alternative system to serialism, all can be examined accordingly. It is also not uninteresting that both composers are convinced that they belong neither to the avant-garde nor to postmodernism, but consistently follow modernism.