THE EFFECT OF METHYLSULFONYLMETHANE ON THE PHYSIOLOGICAL PARAMETERS OF WHITE RATS WITH EXPERIMENTAL CADMIUM AND LEAD INTOXICATION
Authors:   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal State Budget Scientific Institution «Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences», Moscow 123022, Russian Federation, Pavlova Natalia S. , Pavlenko Galina I. ,   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal State Budget Scientific Institution «Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences», Moscow 123022, Russian Federation, Drozdov Dmitry A. ,   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal State Budget Scientific Institution «Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences», Moscow 123022, Russian Federation, Brichko Natalya A. ,   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal State Budget Scientific Institution «Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences», Moscow 123022, Russian Federation, Dorozhkin Vasily I. ,   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal State Budget Scientific Institution «Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences», Moscow 123022, Russian Federation
Published: March 2024

Cadmium and lead, being one of the most dangerous ecotoxicants, are entering feed in an increasing number of regions and then into livestock products, posing a danger to the body of animals and humans. Therefore, the problem of reducing the toxic effect and accumulation of cadmium and lead in the body does not lose its relevance. One of the ways to reduce the accumulation and negative effects of heavy metals (HM) is the use of biologically active substances. Since one of the mechanisms of the toxic effect of heavy metals is the binding of sulfhydry groups, sulfur and preparations containing it are often used to reduce intoxication. Methylsulfonylmethane (MSM) is a sulfur-containing compound that is a natural component of many foods (fruits, vegetables, grains). It has hepatoprotective, antioxidant and antitoxic properties, and is a source of organic sulfur. The introduction of cadmium and lead at a dose of 2,5 and 5 μg/kg into the diet of white rats for two and a half months led to the normalization of the animals’ behavioral indicators, the state of the central nervous system according to the determination of the summation-threshold index (STI), restoration of the level of immunoglobulin, and the content of chlorides in the urine , and in the blood serum – general SH groups, but the hemoglobin content remained significantly low.