bluuebunny/crossref_metadata_2025 huggingface dataset:
Liberalism, Media, and the State of Abandon
Authors: Sutherland Meghan
Published: June 2023

Contemporary political theory places the logic of abandonment at the center of its critique of liberalism, drawing necessary attention to the conditions of statelessness, territorial displacement, and non-recognition that define experiences of liberal and neoliberal governance around the world. Without dismissing this approach, this essay lays out a different way of thinking about both the logic of abandon and its relevance to the political vicissitudes of representation within liberalism. It aims to complicate prevailing frameworks for addressing the problems of liberalism, representation and social responsibility, drawing on images from contemporary protest movements to address the politics of staging media spectacles.
A Response to “On Colonial Unknowing”
Authors: Young Alex Trimble
Published: June 2023

This response to the editors of “On Colonial Unknowing” both acknowledges the vital intervention of their special issue and contests their characterization of settler colonial studies as an “academic field formation” marked by dogmatic and hermetic methodological tendencies. Settler colonial studies, we argue, is a still emergent subfield marked by a dynamic interchange with related fields and disciplinary formations. Settler colonial studies and its critique of a specific and contingent structure of violence has continuing utility, we suggest, not as a hegemonic discourse (a condition the field never aspired to), but rather as a supplement to adjacent field formations engaged in the critique of racialization and empire.
Sub-wavelength, phase-sensitive microscopy of third-order nonlinearity in terahertz frequencies
Authors: Lin Tong , Xu Rui , Chen Xiaotong , Guan Yuxuan , Yao Mingxing , Zhang Junhao , Li Xinwei , Zhu Hanyu
Published: June 2023

The third-order nonlinear susceptibility χ(3) occurs universally in materials and can provide label-free fingerprint of materials’ electronic, vibrational, and structural information. One quantitative spectroscopic method to access low-energy resonances of χ(3) is the terahertz electric field induced second harmonic generation (TEFISH), which is particularly suitable for centrosymmetric materials without second-order processes. However, using TEFISH to measure the χ(3) spectra requires light sources with high spectral intensity, which is challenging for the “new terahertz gap” frequencies between 5 – 15 THz that, not by coincidence, are the fingerprint phonon bands for many materials. Here for the first time, we report phase-sensitive heterodyne TEFISH microscopy offering simultaneous temporal, spectral, and spatial resolution, incorporating intense and frequency-tunable narrowband terahertz source by chirped pulse difference frequency generation in the frequency range of 4 to 18 THz. We demonstrated time-resolved hyperspectral TEFISH microscopy in polymer thin films (SU-8), 2D crystalline semiconductors (MoS2), and sub-wavelength photonic resonators. By interfering the nonlinear emission with a local oscillator field, we quantitatively retrieved the frequency, amplitude, and relative phase of the χ(3) spectra. TEFISH microscopy allows time-resolved imaging of vibrational and photonic resonances with sub-wavelength resolution and higher sensitivity compared to linear Fourier transform infrared spectroscopy, as well as versatility for samples in different environments by avoiding near-field probes.
The FMRF-NH2 gated sodium channel of Biomphalaria glabrata: Localization and expression following infection by Schistosoma mansoni
Authors: Vicente-Rodríguez Laura C. , Torres-Arroyo Amanda C. , Hernández-Vázquez Anthony , Rosa-Casillas Mariela , Bracho-Rincón Dina P. , de Jesús Paola Méndez , Behra Martine L. , Habib Mohamed R. , Zhou Xiao-Nong , Rosenthal Joshua J. C. , Miller Mark W.
Published: June 2023

The neglected tropical disease schistosomiasis impacts over 700 million people globally. Schistosoma mansoni, the trematode parasite that causes the most common type of schistosomiasis, requires planorbid pond snails of the genus Biomphalaria to support its larval development and transformation to the cercarial form that can infect humans. A greater understanding of neural signaling systems that are specific to the Biomphalaria intermediate host could lead to novel strategies for parasite or snail control. This study examined a Biomphalaria glabrata neural channel that is gated by the neuropeptide FMRF-NH2. The Biomphalaria glabrata FMRF-NH2 gated sodium channel (Bgl-FaNaC) amino acid sequence was highly conserved with FaNaCs found in related gastropods, especially the planorbid Planorbella trivolvis (91% sequence identity). In common with the P. trivolvis FaNaC, the B. glabrata channel exhibited a low affinity (EC50: 3 x 10−4 M) and high specificity for the FMRF-NH2 agonist. Its expression in the central nervous system, detected with immunohistochemistry and in situ hybridization, was widespread, with the protein localized mainly to neuronal fibers and the mRNA confined to cell bodies. Colocalization of the Bgl-FaNaC message with its FMRF-NH2 agonist precursor occurred in some neurons associated with male mating behavior. At the mRNA level, Bgl-FaNaC expression was decreased at 20 and 35 days post infection (dpi) by S. mansoni. Increased expression of the transcript encoding the FMRF-NH2 agonist at 35 dpi was proposed to reflect a compensatory response to decreased receptor levels. Altered FMRF-NH2 signaling could be vital for parasite proliferation in its intermediate host and may therefore present innovative opportunities for snail control.
Seroprevalence and associated risk factors of brucellosis, Rift Valley fever and Q fever among settled and mobile agro-pastoralist communities and their livestock in Chad
Authors: Özcelik Ranya , Abakar Mahamat Fayiz , Counotte Michel Jacques , Abdelrazak Zakaria Fatima , Kimala Pidou , Issa Ramadane , Dürr Salome
Published: June 2023

Brucellosis, Rift Valley fever (RVF) and Q fever are zoonoses prevalent in many developing countries, causing a high burden on human and animal health. Only a few studies are available on these among agro-pastoralist communities and their livestock in Chad. The objective of our study was to estimate brucellosis, RVF and Q fever seroprevalence among Chadian agro-pastoralist communities and their livestock, and to investigate risk factors for seropositivity. We conducted a multi-stage cross-sectional serological survey in two rural health districts, Yao and Danamadji (966 human and 1041 livestock (cattle, sheep, goat and equine) samples)). The true seroprevalence were calculated applying a Bayesian framework to adjust for imperfect diagnostic test characteristics and accounting for clustering in the study design. Risk factors for each of the zoonotic diseases were estimated using mixed effects logistic regression models. The overall prevalence for brucellosis, Q fever and RVF combined for both regions was estimated at 0.2% [95% credibility Interval: 0–1.1], 49.1% [%CI: 38.9–58.8] and 28.1% [%CI: 23.4–33.3] in humans, and 0.3% [%CI: 0–1.5], 12.8% [%CI: 9.7–16.4] and 10.2% [%CI: 7.6–13.4] in animals. Risk factors correlating significantly with the respective disease seropositivity were sex for human brucellosis, sex and Q fever co-infection for animal brucellosis, age for human Q fever, species and brucellosis co-infection for animal Q fever, age and herd-level animal RVF seroprevalence within the same cluster for human RVF, and cluster-level human RVF seroprevalence within the same cluster for animal RVF. In Danamadji and Yao, Q fever and RVF are notably seroprevalent among agro-pastoralist human and animal communities, while brucellosis appears to have a low prevalence. Correlation between the seroprevalence between humans and animals living in the same communities was detected for RVF, highlighting the interlinkage of human and animal transmissible diseases and of their health, highlighting the importance of a One Health approach.
Epidemiology of SARS-CoV-2 transmission and superspreading in Salt Lake County, Utah, March–May 2020
Authors: Walker Joseph , Tran Tiffany , Lappe Brooke , Gastanaduy Paul , Paul Prabasaj , Kracalik Ian T. , Fields Victoria L. , Lopez Adriana , Schwartz Amy , Lewis Nathaniel M. , Tate Jacqueline E. , Kirking Hannah L. , Hall Aron J. , Pevzner Eric , Khong Ha , Smithee Maureen , Lowry Jason , Dunn Angela , Kiphibane Tair , Tran Cuc H.
Published: June 2023

Background

Understanding the drivers of SARS-CoV-2 transmission can inform the development of interventions. We evaluated transmission identified by contact tracing investigations between March–May 2020 in Salt Lake County, Utah, to quantify the impact of this intervention and identify risk factors for transmission.

Methods

RT-PCR positive and untested symptomatic contacts were classified as confirmed and probable secondary case-patients, respectively. We compared the number of case-patients and close contacts generated by different groups, and used logistic regression to evaluate factors associated with transmission.

Results

Data were collected on 184 index case-patients and up to six generations of contacts. Of 1,499 close contacts, 374 (25%) were classified as secondary case-patients. Decreased transmission odds were observed for contacts aged <18 years (OR = 0.55 [95% CI: 0.38–0.79]), versus 18–44 years, and for workplace (OR = 0.36 [95% CI: 0.23–0.55]) and social (OR = 0.44 [95% CI: 0.28–0.66]) contacts, versus household contacts. Higher transmission odds were observed for case-patient’s spouses than other household contacts (OR = 2.25 [95% CI: 1.52–3.35]). Compared to index case-patients identified in the community, secondary case-patients identified through contract-tracing generated significantly fewer close contacts and secondary case-patients of their own. Transmission was heterogeneous, with 41% of index case-patients generating 81% of directly-linked secondary case-patients.

Conclusions

Given sufficient resources and complementary public health measures, contact tracing can contain known chains of SARS-CoV-2 transmission. Transmission is associated with age and exposure setting, and can be highly variable, with a few infections generating a disproportionately high share of onward transmission.
Musculoskeletal misdiagnoses in children with brain tumors: A nationwide, multicenter case-control study
Authors: Hallundbæk Laura , Hagstrøm Søren , Mathiasen Rene , Herlin Troels , Hasle Henrik , Weile Kathrine Synne , Amstrup Jesper , Brix Ninna
Published: June 2023

Objective

Childhood brain tumors belong to the cancer type with the longest diagnostic delay, the highest health care utilization prior to diagnosis, and the highest burden of long-term sequelae. We aimed to clarify whether prior musculoskeletal diagnoses in childhood brain cancer were misdiagnoses and whether it affected the diagnostic delay.

Study design

In this retrospective, chart-reviewed case-control study we compared 28 children with brain tumors and a prior musculoskeletal diagnosis to a sex and age-matched control group of 56 children with brain tumors and no prior musculoskeletal diagnosis. Using the Danish registries, the cases were identified from consecutive cases of childhood brain cancers in Denmark over 23 years (1996–2018).

Results

Of 931 children with brain tumors, 3% (28/931) had a prior musculoskeletal diagnosis, of which 39% (11/28) were misdiagnoses. The misdiagnoses primarily included torticollis-related diagnoses which tended to a longer time interval from first hospital contact until a specialist was involved: 35 days (IQR 6–166 days) compared to 3 days (IQR 1–48 days), p = 0.07. When comparing the 28 children with a prior musculoskeletal diagnosis with a matched control group without a prior musculoskeletal diagnosis, we found no difference in the non-musculoskeletal clinical presentation, the diagnostic time interval, or survival. Infratentorial tumor location was associated with a seven-fold risk of musculoskeletal misdiagnosis compared to supratentorial tumor location.

Conclusion

Musculoskeletal misdiagnoses were rare in children with brain tumors and had no significant association to the diagnostic time interval or survival. The misdiagnoses consisted primarily of torticollis- or otherwise neck-related diagnoses.
Underreporting of SARS-CoV-2 infections during the first wave of the 2020 COVID-19 epidemic in Finland—Bayesian inference based on a series of serological surveys
Authors: Nieminen Tuomo A. , Auranen Kari , Kulathinal Sangita , Härkänen Tommi , Melin Merit , Palmu Arto A. , Jokinen Jukka
Published: June 2023

In Finland, the first wave of the COVID-19 epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) took place from March to June 2020, with the majority of COVID-19 cases diagnosed in the Helsinki-Uusimaa region. The magnitude and trend in the incidence of COVID-19 is one way to monitor the course of the epidemic. The diagnosed COVID-19 cases are a subset of the infections and therefore the COVID-19 incidence underestimates the SARS-CoV-2 incidence. The likelihood that an individual with SARS-CoV-2 infection is diagnosed with COVID-19 depends on the clinical manifestation as well as the infection testing policy and capacity. These factors may fluctuate over time and the underreporting of infections changes accordingly. Quantifying the extent of underreporting allows the assessment of the true incidence of infection. To obtain information on the incidence of SARS-CoV-2 infection in Finland, a series of serological surveys was initiated in April 2020. We develop a Bayesian inference approach and apply it to data from the serological surveys, registered COVID-19 cases, and external data on antibody development, to estimate the time-dependent underreporting of SARS-Cov-2 infections during the first wave of the COVID-19 epidemic in Finland. During the entire first wave, there were 1 to 5 (95% probability) SARS-CoV-2 infections for every COVID-19 case. The underreporting was highest before April when there were 4 to 17 (95% probability) infections for every COVID-19 case. It is likely that between 0.5%–1.0% (50% probability) and no more than 1.5% (95% probability) of the adult population in the Helsinki-Uusimaa region were infected with SARS-CoV-2 by the beginning of July 2020.
Essential components of a definition for early antibiotic treatment failure: A scoping review
Authors: Iwata Hiroyoshi , Kaneko Makoto , Aoki Takuya , Endo Koji , Nagai Yuki , Kanto Kenji , Yao Masahiro , Hamada Shuhei
Published: June 2023

Background

Despite the broad global use of antibiotics, there is no established definition of early antibiotic treatment failure (EATF) to aid clinical evaluation of treatment, which leads to inconsistent assessments of drug effectiveness.

Aim

This scoping review aims to identify common components of EATF definitions by synthesizing studies mentioning EATF and its relevant thesaurus matches.

Design

Scoping review

Methods

This scoping review was conducted following the PRISMA Scoping review guidelines. A systematic literature search was conducted using MEDLINE (PubMed), CENTRAL, CINAHL, and Web of Science, as well as a manual Google search. Search terms were EATF and its thesaurus matches. After removing duplications, candidate studies were screened by title and abstract prior to full text searches, and quality analysis was performed on eligible studies using the Critical Appraisal Skills Programme. From each eligible study, the timing of evaluation, basic components, and detailed information for each definition of EATF were collected. The components of each definition for EATF were then summarized and counted, and finally the most common essential components were identified.

Results

Our systematic literature search found 2,472 candidate studies. After title and abstract screening, full text search and quality assessment, 61 studies, including 56 original studies and five reviews, were eligible for our analysis. Of these 56 original studies, 43 mentioned the timing of EATF evaluation 72 hours after the start of treatment with antibiotics. From these 43 studies, the most common indicators of EATF were extracted, among which a set of essential components for a definition of EATF were identified: mortality, vital signs, fever, symptoms, and additional treatment.

Conclusions

Our scoping review uncovered five essential factors for EATF. Further study is needed to evaluate the validity of our findings.
High rates of kidney impairment among older people (≥ 60 years) living with HIV on first-line antiretroviral therapy at screening for a clinical trial in Kenya
Authors: Penner Jeremy , Ombajo Loice Achieng , Otieno Davies , Nkuranga Joseph , Mburu Margaret , Wahome Simon , Pozniak Anton , Bhagani Sanjay
Published: June 2023

Background

There is a paucity of data on kidney impairment among older people living with HIV (PLWH). We evaluated kidney function among PLWH age ≥ 60 years on first-line antiretroviral (ARV) therapy during screening for a clinical trial in Kenya.

Methods

The bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) Elderly Study is an open-label, randomized, active-controlled, non-inferiority trial conducted at two sites in Kenya. Potential participants were screened for study entry if they were at least 60 years old, had been on ARVs for at least 24 weeks and had no history of treatment failure. At screening, participants had samples collected for serum creatinine and estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration 2021 equation.

Results

Between January and April 2022, 714 participants were screened and had creatinine measured. All participants were black, 54.1% were female and the median age was 64 years (range 60 to 87 years). Most participants (666 [93.3%]) were on tenofovir disoproxil fumarate-containing regimens, 711 (99.6%) were on dolutegravir-containing regimens, and only 2 (0.3%) were on a regimen with a ritonavir-boosted protease inhibitor. Most participants (686 [96.6%]) were virally suppressed. Treatment for comorbidities was common, with 175 (24.5%) on treatment for hypertension and 39 (5.5%) on treatment for diabetes mellitus. The median eGFR was 64.7 mL/min/1.73m2, and 289 (40.5%) participants had an eGFR < 60 mL/min/1.73m2. In multivariate analysis, factors associated with lower eGFR were female gender (p<0.001), being on treatment for hypertension (p<0.001) and nadir CD4 count < 50 cells/μL (p = 0.008).

Conclusions

Our study identified high rates of impaired kidney function among elderly PLHW in Kenya, which highlights the importance of routine assessment of kidney function and the need to address modifiable risk factors, use of appropriate ARVs, and management of kidney disease in this population.
Corporate social responsibility stimulus on environmental problems: Spatial threshold model analysis
Authors: Wang Yu , Ahmad Saleem , Waseem Liaqat Ali , Akhter Sonia , Jihane Mokhchy
Published: June 2023

A popular subject of general interest is the connection between corporate social responsibility, research and development, tax policy, and the purchase of green bonds. To encourage the coordinated growth of the economy and a pollution-free environment, it is crucial to understand how they interact. The paper develops a theoretical framework based on the general equilibrium theory’s multi-sector model to examine how tax competition affects environmental degradation. The existence of such an effect, which is a threshold effect resulting from corporate social responsibility (CSR), and how it is impacted by CSR are theoretically established. The study used Moroccan province panel data from 2000 to 2022 and the spatial panel threshold model. The empirical finding demonstrates the importance of the threshold impact of CSR since reduced tax competition tends to worsen environmental degradation when CSR is above the threshold value and to reduce it when CSR is below the threshold value. The study also reveals that the impact of tax competitiveness varies regionally. Several policy suggestions are then put out to assist Morocco in reducing environmental pollution through taxation.
Aged black garlic extract inhibits the growth of estrogen receptor-positive breast cancer cells by downregulating MCL-1 expression through the ROS-JNK pathway
Authors: Yang Qiwei , Li Fang , Jia Guohui , Liu Rui
Published: June 2023

The black garlic is produced from the raw garlic by Milliard reaction at high temperature (~60–90°C) and humidity (~70–90%). In this process, the pungent odor and gastrointestinal irritation effects of the raw garlic are reduced. At the same time, unstable compounds such as allicin are converted into stable organosulfur compounds with antioxidant activity. Previous studies have confirmed that black garlic extract has anti-tumor effects and could inhibit the proliferation of various tumor cells, including breast cancer cells MCF-7. However, the mechanisms of the anti-tumor effects remain unclear. In this study, we found that the black garlic extract could inhibit the proliferation, invasion, and metastasis of estrogen receptor-positive breast cancer cells, promote their apoptosis, and inhibit their epithelial-mesenchymal transition. Mechanistically, the black garlic extract reduced the expression of the anti-apoptotic protein MCL-1, which was achieved by modulating the ROS-JNK signaling pathway. In addition, the black garlic extract also decreased the expression of BCL-2 and increased the expression of BAX and BIM. We also found that the black garlic extract, in combination with venetoclax, a BCL-2 inhibitor, synergistically kills the estrogen receptor-positive breast cancer cells. These results suggested that black garlic extract has great therapeutic value and prospects for estrogen receptor-positive breast cancer treatment.
Neuromodulatory effects and reproducibility of the most widely used repetitive transcranial magnetic stimulation protocols
Authors: Magnuson Justine , Ozdemir Mehmet A. , Mathieson Elon , Kirkman Sofia , Passera Brice , Rampersad Sumientra , Dufour Alyssa B. , Brooks Dana , Pascual-Leone Alvaro , Fried Peter J. , Shafi Mouhsin M. , Ozdemir Recep A.
Published: June 2023

Background

Repetitive transcranial magnetic stimulation (rTMS) is widely used in both research and clinical settings to modulate human brain function and behavior through the engagement of the mechanisms of plasticity. Based upon experiments using single-pulse TMS as a probe, the physiologic mechanism of these effects is often assumed to be via changes in cortical excitability, with 10 Hz rTMS increasing and 1 Hz rTMS decreasing the excitability of the stimulated region. However, the reliability and reproducibility of these rTMS protocols on cortical excitability across and within individual subjects, particularly in comparison to robust sham stimulation, have not been systematically examined.

Objectives

In a cohort of 28 subjects (39 ± 16 years), we report the first comprehensive study to (1) assess the neuromodulatory effects of traditional 1 Hz and 10 Hz rTMS on corticospinal excitability against both a robust sham control, and two other widely used patterned rTMS protocols (intermittent theta burst stimulation, iTBS; and continuous theta burst stimulation, cTBS), and (2) determine the reproducibility of all rTMS protocols across identical repeat sessions.

Results

At the group level, neither 1 Hz nor 10 Hz rTMS significantly modulated corticospinal excitability. 1 Hz and 10 Hz rTMS were also not significantly different from sham and both TBS protocols. Reproducibility was poor for all rTMS protocols except for sham. Importantly, none of the real rTMS and TBS protocols demonstrated greater neuromodulatory effects or reproducibility after controlling for potential experimental factors including baseline corticospinal excitability, TMS coil deviation and the number of individual MEP trials.

Conclusions

These results call into question the effectiveness and reproducibility of widely used rTMS techniques for modulating corticospinal excitability, and suggest the need for a fundamental rethinking regarding the potential mechanisms by which rTMS affects brain function and behavior in humans.
Perceived threat and fear responses to e-cigarette warning label messages: Results from 16 focus groups with U.S. youth and adults
Authors: Avery Rosemary J. , Kalaji Motasem , Niederdeppe Jeff , Mathios Alan , Dorf Michael , Byrne Sahara , Safi Amelia Greiner
Published: June 2023

Aims

A warning on e-cigarette packaging is one way the U.S. government can inform the public of known harms of e-cigarette use. Currently, the only required warning on these products is: “WARNING: This product contains nicotine. Nicotine is an addictive chemical.” This exploratory study aims to inform potential future investigations and FDA decisions regarding alternative warnings that may generate fear in addition to being intentionally informational.

Method

Data were obtained from responses by 16 online focus groups with adult (N = 47, age range = 18–64) and youth (N = 32, age range 14–16) participants with various smoking and vaping experiences. We showed each focus group a set of hypothetical e-cigarette warning labels to determine how they respond to currently existing public statements that communicate information on the toxicity of ingredients in e-cigarettes, potential health risks, addiction to nicotine, and the uncertainty of the science regarding health effects of using these products. The focus group interviews were audio recorded and transcribed. Transcripts were subjected to a multiphase coding process to identify common response themes. Codes derived from the Extended Parallel Processing Model were then applied to understand impact of potentially fear-inducing language by warning category and age group.

Results

For adults, all warnings—except those about addiction—gave rise to spontaneous danger control (intended) responses, such as quit intentions. Warnings highlighting cognitive and uncertain effects may be particularly promising for adult consumers of tobacco products because both gengerated danger control and response efficacy without evidence of fear control. However, responses also suggest that warnings risk discouraging some adults who use combustible cigarettes from transitioning to e-cigarettes for harm reduction. For youth, while evidence of response efficacy and danger control emerged among youth exposed to messages in all warning categories but one–addiction—unproductive reactions indicative of fear control were also prevalent among youth respondent across most warning types. On average, youth were more skeptical than adults about the harms of using e-cigarettes.

Policy implications

Implications of study findings for the development of future effective e-cigarette warning messages are explored.
Consumer heterogeneity for shared accommodations at pre-and-post adoption stages: Insights from travelers in Shanghai, China
Authors: Qin Lei , Fang Eddy S. , Lai Ivan Ka Wai , Han Yu , Liu Yidan
Published: June 2023

As shared accommodation has become one of the most important market developments in the tourism industry, numerous contributions have emerged regarding travelers’ motivations to choose shared accommodation. A debated question, however, resides in the heterogeneity of travelers based on motivations. This paper aims to reconcile opposing perspectives by comparing motivation segmentation at two distinct phases of the adoption of this accommodation option: (i) before the first travel–potential users showing interest (n = 420) and (ii) after the first travel–current users (n = 420). Factor analysis, combined with clustering, is applied to both samples to identify underlying motivations and traveler segments. Interestingly, we find that factors defining choice motivations are relatively stable throughout the adoption process, but the heterogeneity of motivations among travelers is higher in users, increasing from three to six clusters. This suggests that travelers’ motivations are dynamic and dependent on the phase of adoption.
Rural and urban residents’ attitudes and preferences toward COVID-19 prevention behaviors in a midwestern community
Authors: Maciejko Laura A. , Fox Jean M. , Steffens Michelle T. , Patten Christi A. , Newman Hana R. , Decker Paul A. , Wheeler Phil , Juhn Young J. , Wi Chung-Il , Gorfine Mary , Brewer LaPrincess , Sinicrope Pamela S.
Published: June 2023

Rural populations are more vulnerable to the impacts of COVID-19 compared to their urban counterparts as they are more likely to be older, uninsured, to have more underlying medical conditions, and live further from medical care facilities. We engaged the Southeastern MN (SEMN) community (N = 7,781, 51% rural) to conduct a survey of motivators and barriers to masking to prevent COVID-19. We also assessed preferences for types of and modalities to receive education/intervention, exploring both individual and environmental factors primarily consistent with Social Cognitive Theory. Our results indicated rural compared to urban residents performed fewer COVID-19 prevention behaviors (e.g. 62% rural vs. 77% urban residents reported wearing a mask all of the time in public, p<0.001), had more negative outcome expectations for wearing a mask (e.g. 50% rural vs. 66% urban residents thought wearing a mask would help businesses stay open, p<0.001), more concerns about wearing a mask (e.g. 23% rural vs. 14% urban were very concerned about being ‘too hot’, p<0.001) and lower levels of self-efficacy for masking (e.g. 13.9±3.4 vs. 14.9±2.8, p<0.001). It appears that masking has not become a social norm in rural SEMN, with almost 50% (vs. 24% in urban residents) disagreeing with the expectation ’others in my community will wear a mask to stop the spread of Coronavirus’. Except for people (both rural and urban) who reported not being at all willing to wear a mask (7%), all others expressed interest in future education/interventions to help reduce masking barriers that utilized email and social media for delivery. Creative public health messaging consistent with SCT tailored to rural culture and norms is needed, using emails and social media with pictures and videos from role models they trust, and emphasizing education about when masks are necessary.
Experimental investigation of novel ternary amine-based deep eutectic solvents for CO2 capture
Authors: Abdrabou Hossam K. , AlNashef Inas , Abu Zahra Mohammad , Mokraoui Salim , Ali Emad , Hadj-Kali Mohamed K.
Published: June 2023

This study investigates the effect of using water as a low-viscosity component in ternary amine-based deep eutectic solvents (DESs) on the physicochemical properties, thermal stability, and CO2 absorption capacity of the resulting DESs. It should be emphasized that water is a component of the ternary DES. The effect of water content in the DES, type of hydrogen bond acceptors (HBAs), hydrogen bond donors (HBDs), and HBA:HBD ratio on the above parameters was investigated. Moreover, the effect of temperature and pressure on the CO2 absorption capacity of DESs was predicted using the predictive model COSMO-RS. This model was also used to predict the CO2 solubility in the DESs and the results were compared with the experimental values. The results showed that the addition of small amounts of water, e.g., 5 and 10 wt% during preparation, can significantly decrease the viscosity of the resulting DESs, up to 25% at room temperature, while maintaining the high CO2 absorption capacity and high thermal stability. The ternary DESs based on MEA exhibited a high CO2 absorption capacity of 0.155–0.170 g CO2 / g DES. The ternary DESs were found to be thermally stable with a decomposition temperature of 125°C, which promotes the use of such solvents in post-combustion capture processes. Finally, COSMO-RS proved to be a suitable tool for qualitative prediction of CO2 solubility in DESs and demonstration of trends related to the effects of temperature, pressure, molar ratio, water content, HBD and HBA on CO2 solubility.
Automatic feature selection for performing Unit 2 of vault in wheel gymnastics
Authors: Kitajima Eiji , Sato Takashi , Kurata Koji , Miyata Ryota
Published: June 2023

We propose a framework to analyze the relationship between the movement features of a wheel gymnast around the mounting phase of Unit 2 of the vault event and execution (E-score) deductions from a machine-learning perspective. We first developed an automation system from a video of a wheel gymnast performing a tuck-front somersault to extract the four frames highlighting its Unit 2 performance of the vault event, such as take-off, pike-mount, the starting point of time on the wheel, and final position before the thrust. We implemented this automation using recurrent all-pairs field transforms (RAFT) and XMem, i.e., deep network architectures respectively for optical flow estimation and video object segmentation. We then used a markerless pose-estimation system called OpenPose to acquire the coordinates of the gymnast’s body joints, such as shoulders, hips, and knees then calculate the joint angles at the extracted video frames. Finally, we constructed a regression model to estimate the E-score deductions during Unit 2 on the basis of the joint angles using an ensemble learning algorithm called Random Forests, with which we could automatically select a small number of features with the nonzero values of feature importances. By applying our framework of markerless motion analysis to videos of male wheel gymnasts performing the vault, we achieved precise estimation of the E-score deductions during Unit 2 with a determination coefficient of 0.79. We found the two movement features of particular importance for them to avoid significant deductions: time on the wheel and angles of knees at the pike-mount position. The selected features well reflected the maturity of the gymnast’s skills related to the motions of riding the wheel, easily noticeable to the judges, and their branching conditions were almost consistent with the general vault regulations.
Potential domestication and tameness effects on prosocial behaviour in chickens
Authors: Oscarsson Rebecca , Jensen Per
Published: June 2023

Prosocial behaviour is pronounced in humans and prevalent in some non-human animals, however, the occurrence of the trait in chickens has not yet been investigated. Here, we studied the occurrence of prosociality in four different lines of adult female chickens. To explore the effects of domestication, chickens of the domesticated layer White Leghorn (WL) and the ancestral Red Junglefowl (RJF) were compared. Additionally, to explore the role of tameness, Red Junglefowl selected for high (RJF HF), or low (RJF LF) fear of humans were also studied. The hens were all tested in a prosocial choice task adapted from a previous study conducted on rats. Each individual was first trained to differentiate between a compartment where itself and a companion received food treats simultaneously (representing a prosocial choice), and one where only itself received the treat. Following training, each bird was tested in a free-choice set-up. No occurrence of prosociality was found at group level in any of the lines, however, our results suggest that the trait may occur in some individuals, and that domestication and increased tameness may have increased its prevalence, although alternative explanations such as side bias and social competition cannot be ruled out. Since this study is the first of its kind, further research is required to make any definite conclusions.
Correlates of support for international vaccine solidarity during the COVID-19 pandemic: Cross-sectional survey evidence from Germany
Authors: Stoeckel Florian , Thompson Jack , Szewach Paula , Stöckli Sabrina , Barnfield Matthew , Phillips Joseph B. , Lyons Benjamin , Mérola Vittorio , Reifler Jason
Published: June 2023

During the COVID-19 pandemic, many residents of high-income countries (HICs) were eligible for COVID-19 vaccine boosters, while many residents of lower-income countries (LICs) had not yet received a first dose. HICs made some efforts to contribute to COVID-19 vaccination efforts in LICs, but these efforts were limited in scale. A new literature discusses the normative importance of an international redistribution of vaccines. Our analysis contributes an empirical perspective on the willingness of citizens in a HIC to contribute to such efforts (which we term international vaccine solidarity). We analyse the levels and predictors of international vaccine solidarity. We surveyed a representative sample of German adults (n = 2019) who participated in a two-wave YouGov online survey (w1: Sep 13–21, 2021 and w2: Oct 4–13, 2021). International vaccine solidarity is measured by asking respondents preferences for sharing vaccine supplies internationally versus using that supply as boosters for the domestic population. We examine a set of pre-registered hypotheses. Almost half of the respondents in our sample (48%) prioritize giving doses to citizens in less developed countries. A third of respondents (33%) prefer to use available doses as boosters domestically, and a fifth of respondents (19%) did not report a preference. In line with our hypotheses, respondents higher in cosmopolitanism and empathy, and those who support domestic redistribution exhibit more support for international dose-sharing. Older respondents (who might be more at risk) do not consistently show less support for vaccine solidarity. These results help us to get a better understanding of the way citizens’ form preferences about a mechanism that redistributes medical supplies internationally during a global crisis.
Geodesics to characterize the phylogenetic landscape
Authors: Khodaei Marzieh , Owen Megan , Beerli Peter
Published: June 2023

Phylogenetic trees are fundamental for understanding evolutionary history. However, finding maximum likelihood trees is challenging due to the complexity of the likelihood landscape and the size of tree space. Based on the Billera-Holmes-Vogtmann (BHV) distance between trees, we describe a method to generate intermediate trees on the shortest path between two trees, called pathtrees. These pathtrees give a structured way to generate and visualize part of treespace. They allow investigating intermediate regions between trees of interest, exploring locally optimal trees in topological clusters of treespace, and potentially finding trees of high likelihood unexplored by tree search algorithms. We compared our approach against other tree search tools (Paup*, RAxML, and RevBayes) using the highest likelihood trees and number of new topologies found, and validated the accuracy of the generated treespace. We assess our method using two datasets. The first consists of 23 primate species (CytB, 1141 bp), leading to well-resolved relationships. The second is a dataset of 182 milksnakes (CytB, 1117 bp), containing many similar sequences and complex relationships among individuals. Our method visualizes the treespace using log likelihood as a fitness function. It finds similarly optimal trees as heuristic methods and presents the likelihood landscape at different scales. It found relevant trees that were not found with MCMC methods. The validation measures indicated that our method performed well mapping treespace into lower dimensions. Our method complements heuristic search analyses, and the visualization allows the inspection of likelihood terraces and exploration of treespace areas not visited by heuristic searches.
A sixfold urban design framework to assess climate resilience: Generative transformation in Negril, Jamaica
Authors: Dhar Tapan Kumar , Khirfan Luna
Published: June 2023

The uncertainty of climate change’s impacts hinders adaptation actions, particularly micro-scale urban design interventions. This paper proposes a sixfold urban design framework to assess and enhance the resilience of urban form to climate change, where urban form refers to the patterns of streets, buildings, and land uses. The framework is then applied to Long Bay in Negril, Jamaica–a coastal area that incorporates the complex interactions between urbanization and a highly vulnerable socio-ecological system to climate change-related hazards, primarily sea-level rise. Empirical evidence from 19 in-depth interviews with planning and design professionals and development actors, in situ observations, and morphological analyses reveal that Long Bay’s current adaptation strategies heavily rely on bounce-back resilience measures that predominantly consider the impacts of extreme climatic events rather than slow-onset ones. Such strategies abet current tourism-driven development patterns while overlooking Long Bay’s inherent abilities for generative transformation and incremental changes to meet climatic uncertainty. Instead, this study’s findings highlight how generative urban form transformation would better equip Long Bay to cope with future uncertainty–climatic or other.
The impact of COVID-19 pandemic on tobacco use: A population-based study
Authors: Alomari Mahmoud A. , Khabour Omar F. , Alzoubi Karem H. , Maikano Abubakar B.
Published: June 2023

Background

Various aspects of lifestyle seem to change during confinement, particularly during the COVID-19 pandemic. The current study examines confinement’s effects on tobacco smoking habits (SH).

Methods

A survey was distributed among adults living in Jordan (age >18 years) of both genders during April-May of 2020, of which 1925 responded to the survey.

Results

The prevalence of smoking was 33.3%, 46.1%, and 21.1% for cigarettes (Cg), waterpipe (Wp), and E-cigarettes (ECg), respectively. Among the smokers, 38.5–45.8% reported a “no-change,” while 32.1–41.7% reported a “decrease” in SH during confinement. On the other hand, 18.0–22.1% reported an “increase” in the SH. However, concerning the factors that might affect SH, the results showed that age, gender, income, and job sector contribute to the observed changes.

Conclusions

Changes in the SH during COVID-19 have been reported in about 50% of participants who smoke tobacco, with a more reported decrease than increase in use. Studies and interventions are needed to confirm further and understand the current results and discourage smoking during the COVID-19 pandemic.
School absenteeism in children with special health care needs. Results from the prospective cohort study ikidS
Authors: Schlecht Jennifer , König Jochem , Kuhle Stefan , Urschitz Michael S.
Published: June 2023

Objective

Children with special health care needs (SHCN) due to a chronic health condition perform more poorly at school compared to their classmates. There is still little knowledge on the causal pathways and which factors could be targeted by interventions. We, therefore, investigated school absenteeism in children with SHCN compared to their peers.

Methods

This study was based on data from the German population-based prospective cohort study ikidS (German for: I will start school). Children with SHCN were identified by the Children with Special Health Care Needs screener that captures five consequences of physical or mental chronic health conditions: (1) use or need of prescription medication, (2) above average use or need of medical, mental health, or educational services, (3) functional limitations compared with others of the same age, (4) use or need of specialized therapies, and (5) treatment or counseling for emotional, behavioral, or developmental problems. School absenteeism was defined as days absent from school due to illness during first grade and was reported by classroom teachers. Associations between SHCN consequences and school absenteeism were investigated by negative binomial regression models. Effect estimates were adjusted for confounding variables identified by a causal framework and directed acyclic graphs.

Results

1,921 children (mean age at follow-up 7.3 years, standard deviation 0.3; 49% females) were included; of these, 14% had SHCN. Compared to their classmates, children with SHCN had more days absent (adjusted rate ratio: 1.37; 95% confidence interval 1.16, 1.62). The effect was strongest among children with i) functional limitations, ii) treatment or counseling for emotional, behavioral, or developmental problems, and iii) those who experienced two or more SHCN consequences.

Conclusions

Children with SHCN have higher school absenteeism, which could–at least partly–explain their poorer school performance and lower educational attainment. SHCN-specific targeted interventions may reduce the adverse effects of SHCN on educational outcomes in children.
Trends change in teen pregnancy among adolescent women in Ethiopia based on Ethiopian demographic and health surveys: Multivariate decomposition analysis
Authors: Alamneh Gebeyehu Asaye , Teshome Assefa Agegnehu , Teshager Wondwosen , Teshome Fentaw , Tiruneh Mulu , Dessie Anteneh Mengist , Anely Denekew Tenaw , Tesfaw Aragaw , Damtie Dejen Gedamu , Yenew Chalachew
Published: June 2023

Background

Teenage pregnancy may adversely affect their health, economic, and social life. Evidence shows that no studies in Ethiopia used decomposition analysis to identify factors for the trend change in teen pregnancy. Therefore, this study aimed to examine the trends and identify contributing factors to teen pregnancy in Ethiopia using multivariate decomposition analysis.

Method

We obtained the data on adolescent women from three Ethiopian Demographic and Health Surveys. A weighted sample of 3266 in 2005, 4009 in 2011, and 3381 teenagers in 2016 were involved in this study. Statistical analysis was performed using STATA 14. Multivariate decomposition analysis was used to identify contributing factors to the change in teen pregnancy. The coefficient value with a 95% confidence interval was used to identify significant factors associated with teen pregnancy.

Results

The prevalence of teen pregnancy in Ethiopia decreased significantly from 15.9% [95% CI: 14.3, 17.7] in 2005 to 12.5% [95% CI: 10.8, 14.3] in 2016. Multivariate decomposition analysis showed that approximately 83% of the overall change in teen pregnancy over time was due to differences in women’s composition. Age, marital status, education status, working status, contraceptive use, and sexual status before age 18 were statistically significant contributing factors to the decline in teen pregnancy over time.

Conclusion

The prevalence of teen pregnancy in Ethiopia decreased significantly over time. The overall decline in teenage pregnancy is due to differences in population composition. Public health interventions should focus on changing cultural norms or attitudes regarding early marriage and pregnancy within religious leaders and uneducated communities.