bluuebunny/crossref_metadata_2025 huggingface dataset:
OSMOTIC DRUG DELIVERY SYSTEM OF NICORANDIL: DESIGN AND EVALUATION
Authors: CHOUDHARY SRILATHA , SUBRAHMANYAM CVS , PRIYANKA K.
Published: May 2024

Objective: The purpose of the current research was to design a nicorandil formulation with controlled drug release using the principles of osmotic pump technology. Nicorandil is a biopharmaceutical classification system (BCS) class 3 drug, having a shorter plasma elimination half-life and bioavailability of 75 to 80%.
Methods: The elementary osmotic pump (EOP) was prepared by coating a cellulose acetate polymer on the prepared core tablet. A 24-factorial design was applied to optimize the parameters for the osmotic tablet. A surface orifice was drilled.
Results: Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) results showed that there was no interaction between drugs and excipients. A 24-factorial design was applied to optimize the parameters for the elementary osmotic pump. The optimized batch was characterized for in vitro drug release studies, and the effects of pH, osmotic pressure, and agitation intensity were analyzed. All the batches showed a drug release ranging from 90.48% to 98.78% after 12 hours. There was no change in the drug release pattern at different pHs and agitation intensities. The drug release was found to decrease with the increasing osmotic pressure of the dissolution medium. The results showed that the amounts of sodium chloride and mannitol were positively affecting the drug release, while the plasticizers PEG400 and DBP were not critical. Scanning electron microscopic studies (SEM) showed the integrity and surface morphology of the coating membrane before and after dissolution. The prepared EOP was found to deliver nicorandil at zero-order for up to 12 hours.
Conclusion: Nicorandil was developed successfully as a controlled drug delivery during a 12-hour period, with variables optimized by the use of a 24-factorial design.
ANTIBIOTICS IN INDONESIA: ACCESS, WATCH, AND RESERVE CLASSIFICATION
Authors: AGUSTINA AMBARITA DIRGAHAYUNI SARI , OKTAMIANTI PUPUT , TRISNADEWI I GUSTI AYU
Published: May 2024

Objective: The objective of this study is to compare antibiotics listed in the National Essential Medicines List (NEML) and national formulary in Indonesia by determining the proportion of antibiotics in the three groups, Access, Watch, and Reserve (AWaRe), along with median data, range values, and time trends from 2013 to 2021.
Methods: We obtained the compilation of antibiotics from the NEML and national formulary in Indonesia, covering the period from 2013 to 2021. These antibiotics were evaluated according to the 2021 WHO AWaRe classification database. This analysis involved determining the proportion of antibiotics in the AwaRe groups within each healthcare facility. Median data and range values for these antibiotics were also calculated. Trends in the proportion of AWaRe antibiotics were analyzed and visualized using a line chart.
Results: The Indonesian NEML includes 20 antibiotics, categorized into two tiers of healthcare settings. Of these antibiotics, 13 were access, seven were watch, and there was neither a reserve nor a not recommended antibiotic. The Indonesian national formulary includes 42 antibiotics, categorized into three tiers of healthcare settings. Of these antibiotics, 19 were access, 22 were watch, one was not recommended, and there was no reserve antibiotic. The proportion of antibiotics during the pre-and post-establishment of the WHO AWaRe in 2017 showed significant changes in the Indonesian national formulary but not in the NEML.
Conclusion: In recent years, the proportions of antibiotics in the Indonesian NEML and national formulary have varied according to the WHO AWaRe classification.
PREDICTION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM PLASMA LEVELS FROM TABLETS AND DISSOLUTION MEDIA OF PHYSIOLOGICAL RELEVANCE
Authors: RIOS-RODRIGUEZ JOSE MANUEL , REYES-RAMIREZ FELIPE DINO , RUIZ-SEGURA JUAN CARLOS , MEDINA-LOPEZ JOSE RAUL
Published: May 2024

Objective: To estimate plasma concentrations-time profiles of Sulfamethoxazole (SMZ) and Trimethoprim (TMP) from fixed-dose combination formulations through in vitro data of dissolution media of physiological relevance and a convolution model.
Methods: Dissolution profiles of SMZ/TMP tablets (400/80 mg) were obtained with USP paddle apparatus at 100 rpm and 900 ml of 0.1 N HCl, pH 4.5 acetate buffer, and pH 6.8 phosphate buffer. The reference drug product and two generic formulations were tested. Drugs were quantified by a derivative method. Dissolution profiles were compared with model-dependent and independent methods. SMZ/TMP plasma levels were simulated with dissolution data and published in vivo information. Percent of prediction error (PE) for peak plasma concentration (Cmax) and area under the curve from zero time to infinity (AUC0-inf) at each condition were calculated.
Results: In all used conditions, similar dissolution profiles were found excepting for TMP at pH 1.2 (f2<50). The in vitro release performance for reference and generic formulations was explained by the Weibull function only for SMZ at pH 6.8 and TMP at pH 4.5. Values of PE>19% for both generic formulations were found with TMP at pH 1.2.
Conclusion: Significant differences in TMP dissolution profiles of generic formulations at pH 1.2 reflect the subsequent differences found in predicted Cmax and AUC0-inf.
CHIRAL SWITCHING CONTROL OF PHARMACEUTICAL SUBSTANCES
Authors: LEVITSKAYA OLGA V. , PLETENEVA TATIANA V. , GALKINA DARIA A. , KHODOROVICH NADEZDA A. , USPENSKAYA ELENA V. , SYROESHKIN ANTON V.
Published: May 2024

Objective: The aim of this study was to demonstrate that chiral switching should be recognized as a widespread phenomenon that extends beyond the production of pure enantiomeric drugs.
Methods: To investigate the optical activity of substances from various chemical classes, enantiomers of chiral compounds (Sigma-Aldrich, USA) were chosen: valine and its racemic form (D-valine, L-valine, and racemic valine with optical purity ≥ 99%), L-ascorbic acid (content ≥ 99%), carbohydrates (D-glucose, D-galactose, L-galactose, contents ≥ 99.5%). Solutions were prepared using deuterium-depleted water (DDW–"light" water, D/H=4 ppm), natural deionized high-ohmic water (BD, D/H=140 ppm), and heavy water (99.9% D2O; Sigma-Aldrich). Optical activity was measured using the Atago POL-1/2 polarimeter.
Results: One of the components in the racemic medication mixture can act as an inert agent, exhibit toxicity, or undergo undesirable biotransformation mechanisms, resulting in the formation of products with unknown properties. It has been established that a change in the deuterium/protium (D/H) ratio in water leads to a change in the equilibrium and kinetic characteristics of optically active compounds across various chemical classes, such as amino acids, carboxylic acids, and carbohydrates. An inequality was observed in the absolute values of the optical rotation of the L-and D-isomers of valine and galactose, depending on the D/H isotope ratio. The impact of chiral water clusters on optical rotation accounts for the sudden shift in the specific rotation of dilute solutions (less than 0.5%) of L-ascorbic acid in water, based on the D/H ratio. The influence of the isotopic composition of water was confirmed by studying the temperature-dependent mutarotation kinetics of D-glucose and L-and D-galactose in Arrhenius coordinates.
The mutarotation process in natural high-resistivity water is characterized by an activation energy (Ea) of 40.8±1.4 kJ mol-1, while in deuterium-depleted water, Ea = 63.6±3.5 kJ mol-1. This results in a kinetic isotope effect for deuterium (KIED) of 1.6.
Conclusion: Methodological approaches have been developed to control chiral switching based on the isotopic composition of water in vivo and in vitro. The study of changes in the optical activity of hierarchical structures in the human body, the influence of solvent properties on the mechanisms of optical rotation, as well as the use of KIED values, can be utilized to monitor various chiral transitions in vitro and living organisms.
AN UPDATED REVIEW OF STEALTH LIPOSOMES AND ITS ABILITY TO EVADE THE IMMUNE SYSTEM: A NEW FRONTIER IN CANCER CHEMOTHERAPY
Authors: SIVADASAN DURGARAMANI
Published: May 2024

Liposomes have been the delivery of choice for the cancer targeting therapy for the last few decades. Since the 1990s, the development of sterically stabilized (stealth) liposomes has garnered interest for their long circulating half-life. PEGylated (Polyethylene Glycol) liposomes are most extensively studied for delivering cancer therapeutics in a sustained manner. Stealth liposomes are having a less intrinsic toxicity with higher efficacy in cancer treatment. There are numerous clinical trials on the liposomes in tackling cancer is evident for the better outcome of the delivery system. Stealth liposomes are extensively studied for their improved circulation time and better pharmacokinetic profile in cancer treatment. The steric hindrance of the stealth liposomes bypasses the reticuloendothelial system clearance. Further the ligands conjugation in the surface of the liposomes able to achieve better target to the cancer cells. The vascularization nature of the cancerous cells is readily making the liposomal delivery of the cancer drugs accumulate in the cancerous cells rather than healthy cells. There is an utmost need to understand the possible mechanism of stealth liposomes and the basic science behind the development of liposomal delivery system in advancing the cancer treatment with less toxicity. The present review addresses the various modalities of the liposomal development, liposome characterization, mechanism of PEGylated liposomes, the advancements and results of the liposomes in the treatment of various diseases, and the clinical trials and regulatory considerations of liposomal drug delivery system.
FORMULATION AND STABILITY EVALUATION OF ANTI-OBESITY NUTRACEUITCAL BLEND OF WHITE KIDNEY BEAN EXTRACT (PHASEOLUS VULGARIS L.), PROPOLIS ETHANOLIC EXTRACT AND CRPIC3
Authors: ELDIN ABDELFATTAH DOAA SALAH , FOUAD MERVAT A. , ELMESHAD ALIAA N. , El-NABARAWI MOHAMED A. , ELHABAL SAMMAR FATHY
Published: May 2024

Objective: This study aimed to formulate and evaluate the stability profile of an anti-obesity nutraceutical combination in different dosage forms.
Methods: Active and inactive ingredients were formulated into pharmaceutical dosage forms. The quality parameters of the dosage forms were determined, followed by accelerated stability testing (40±2 °C and 75±5% Relative Humidity (RH)) for 180 d was completed to evaluate their physical, chemical and microbiological attributes throughout the storage period.
Results: Pre-formulation parameters of the powder blend of active and inactive ingredients for each dosage form showed a satisfactory flowability with Hausner's ratio falling between 1.16 and 1.18, average angle of repose between 22.29° and 22.90° and acceptable compressibility with Carr’s index below 25%. Tablets assessments were acceptable with a mean friability value of 0.21±0.03%, hardness of 4.12±0.09 kg/cm2. The average disintegration time of 5 min 10 sec for tablets and 4 min and 30 sec for capsules. The accelerated stability study revealed that tablet dosage forms are stable for longer period that can reach up to 180 d (24 mo real-time), while sachets and capsules are stable for a period of 135 d (18 mo real-time).
Conclusion: The anti-obesity blend of White Kidney Bean Extract (WKBE), Propolis Ethanolic Extract (PEE) and CrPic3 can be successfully formulated in acceptable and convenient dosage forms that can be stable for 18-24 mo.
Meaning and Components of Parent Empathy Ability: A Delphi Study
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Song Joung-Mi , Moon Hyuk-Jun
Published: May 2024

Objectives This study aims to clarify the meaning of parental empathy ability using the Delphi technique and to derive constituent and sub-factors.
Methods To this end, the concept of parental empathy ability was defined through preceding research and liter-ature review, and the structuring factors of the ability were derived. An expert Delphi survey was conducted using the derived data to confirm the exploratory study of deriving the components of parental empathy ability. The data analysis method of the first Delphi survey questionnaire was conducted in order to define the concept of parental empathy and derive the structuring factors. A structured questionnaire, free-choice and open-ended questions were conducted with 13 experts in order to confirm the content validity. Using SPSS 25.0, the average value, standard deviation, skewness, agreement, convergence, and CVR ranges of each variable were calculated, and questions that did not meet each criterion were modified and deleted. Since the number of panels participating in the Delphi survey in this study is 13, if the CVR value is .554 or higher, it can be judged that the content validity is valid. The contents, were revised and supplemented with the experts, used to construct the second Delphi survey. It was used to construct the second questionnaire by reflecting the opinions of experts and revising and supplementing the contents. The second survey tool were gathered from the responses of the first survey. In or-der to clarify the opinions of each panel, structured questions with a 5-point rating scale were presented.
Results First, the area of the scale consisted of three areas: ‘emotional empathy ability’, ‘cognitive empathy abil-ity’, and ‘behavioral empathy ability’, ‘emotional empathy ability’ consisted of perspective acceptance, cognitive empathy, and perspective acceptance, ‘cognitive empathy ability’ consisted of emotional response, emotional al-location, and emotional perception, and ‘behavioral empathy ability’ consisted of pseudo-movement, expression consistency, listening, and relationship formation.
Conclusions The study is significant in that it derives categories and sub-factors of parental empathy ability that have recently come into focus. Furthermore, the study is significant in that it can be used as basic data for deriving the question composition through focus group interviews in the future.
The Effects of Body Image, Self-Esteem, and Eating Attitudes on Dieting Behavior in Nursing Students Based on BMI
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Ji Hun , Kim Ye Ram , Kim Yu Jin , Kim Ha Eun , Ko Hana
Published: May 2024

Objectives This research aimed to investigate the extent of dieting behaviors among nursing students and to ex-amine the impact of body image, self-esteem, and eating attitudes on dieting behaviors based on BMI.
Methods The study included 135 nursing students located in Seoul, Gyeonggi, and Incheon. Data collection was conducted from October 17th to November 3rd, 2023. Data analysis was carried out using SPSS WIN/29.0 and included the calculation of means, standard deviations, Pearson correlation coefficients, and multiple regression analysis.
Results The research results revealed that the average dieting behavior score of nursing students was 2.70. Depending on their body mass index (BMI), the scores were 2.00, 2.79, 2.59, and 3.67, respectively. When ana-lyzing the relationship between nursing students' body image, self-esteem, eating attitudes, and dieting behav-ior, significant positive correlations were found with the subjects' gender, BMI, body image, and self-esteem. The factors influencing nursing students' dieting behaviors were identified as gender, BMI, body image, and self-es-teem, with an explanatory power of 14.6%.
Conclusions Based on the findings of this study, it is suggested to develop individualized diet behavior inter-ventions to promote positive eating attitudes and self-esteem among nursing students based on their BMI. Subsequent research should focus on evaluating these interventions.
Lacunas in the Study of Islam in Russia (based on the dictionary “Islam in the Russian Federation”)
Authors: Makarov D. V.
Published: May 2024

This article is devoted to the intermediate results of the project of the series of encyclopedic dictionaries “Islam in the Russian Federation” (at the stage of publication of all regional volumes, but before the release of the consolidated edition). This project, for the ﬁrst time in the history of Russian Islamic studies, set the goal of covering the entire territory of the country with the research grid. A number of difficulties and problems arose in achieving this goal. One of them was the lack of works on this subject in a number of regions of the country, and even the absence of researchers who would deal with this issue. Since the previous research and encyclopedic projects did not even aim at universal coverage, they could not describe the “white spots” (spatial and temporal lacunas). In addition, one of the reasons for this project was the involvement of about 600 specialists of different proﬁles, including historians, archaeologists, sociologists, source specialists, ethnologists, numismatists, local historians and others. This multidisciplinarity and the large number of specialists with different points of view created certain difficulties in the work on the project, but they also made it possible to achieve the goal of creating a holistic picture of the history of Islam in Russia. It is only now that it is possible to deﬁne and outline these very “white spots” that have been identiﬁed and “mapped” in the course of this project.
Teoria da educação e pressupostos didáticopedagógicos
Authors: Bernardo Silva Matheus
Published: May 2024

Este artigo tem como objetivo explicitar a importância da teoria da educação, principalmente da teoria pedagógica histórico-crítica, bem como de determinados desdobramentos didático-pedagógicos, para perspectivar e consolidar uma educação integral escolar, em especial na escola pública. A partir de uma pesquisa teórico-bibliográfica, buscou-se apoio nos fundamentos da pedagogia histórico-crítica para estabelecer pressupostos que contribuam com o processo formativo integral do/da aluno/a em um sentido omnilateral. Em nota propositiva, conclui-se sobre a importância de enfatizar uma teoria pedagógica (enquanto ciência autônoma e unificada da e para a educação) para o trabalho educativo, capaz de oportunizar condições objetivas no processo de ensino e aprendizagem, para o processo formativo integral do/da aluno/a. Para isso, não basta qualquer teoria pedagógica, mas uma que parta de uma concepção crítica, mais precisamente, a concepção histórico-crítica de educação.
Embodied Landscapes: process and participation in filmmaking
Authors: Rachael Jones
Published: May 2024

This page is a diagrammatic visualisation of my doctoral thesis. Originally presented as a digital PDF and at just under 50,000 words, it was important that it comprised all the collages, photographs, diagrams and films (as hyperlinks) that made it practice-based artistic research. This space allows the work and ideas to be experienced less sequentially and more relationally, befitting a nonlinear research practice assemblage.
Future decline of Antarctic Circumpolar Current due to polar ocean freshening
Authors: Sohail Taimoor , Gayen Bishakhdatta , Klocker Andreas
Published: May 2024

Abstract content goes here
Multi-proxy estimates of sea surface temperature and CO2 in the western Atlantic during the Late Miocene
Authors: Tanner Thomas , Rae James William Buchanan , Hernández-Almeida Iván , Zhang Hongrui , Jaggi Madalina , Dumont Matthew , Jurikova Hana , Bernasconi Stefano M. , Stoll Heather
Published: May 2024

Reconstructing atmospheric CO2 concentration in the Late Miocene is
crucial for understanding the relationship between greenhouse gas
concentrations and climate change in a warmer-than-modern world. Both
δ11B-based and alkenone-ep-based CO2 estimates feature uncertainties due
to poorly constrained past seawater chemistry, and algal physiological
processes, respectively. Additionally, both proxies estimate
CO2[aq], so they require reliable surface ocean temperatures to
calculate solubility and atmospheric CO2. To evaluate proxy coherence,
in this study we generate new records of alkenone ep and δ11B, from the
western Tropical Atlantic ODP Site 926 during the Late Miocene. We
provide surface ocean temperature estimates from coccolith clumped
isotope thermometry, alkenone undersaturation ratios, and planktonic
foraminiferal Mg/Ca ratios. The warm temperatures estimated from our new
clumped isotope records, together with alkenone temperatures
>29°C, confirm warm tropics, and provide constraints on the
assumptions of seawater Mg/Ca and dissolution corrections for
foraminiferal Mg/Ca SST estimates. The new alkenone ep CO2 estimates at
926 yield generally similar CO2 as the new and published δ11B-based CO2
records for the site, and are similar to published alkenone ep CO2
records from the South Atlantic ODP Site 1088. However, over the 7.3 to
7.8 Ma interval, the CO2 values from ep are lower than other records. We
evaluate which proxy indicators can best predict variations in algal
physiology which may bias the ep-based CO2 reconstructions in this
interval at Site 926.
Western United States wintertime precipitation response to warming: an assessment in a global storm-resolving model
Authors: Hsieh Tsung-Lin , Harris Lucas , Cheng Kai-Yuan , Zhou Linjiong , Jia Liwei , Zhao Ming
Published: May 2024

Years-long global storm-resolving simulations of the present and warmed
climates are conducted with 3.25km horizontal grid spacing. We focus on
wintertime precipitation in the coastal western United States, a notably
water-sensitive region with complex topography. The model generates more
realistic orographic precipitation compared with a coarser-resolution
model having the same dynamical core. In response to uniform sea surface
warming, the increase in extreme precipitation rates together with the
better resolved orographic precipitation lead to persistence of snowpack
in parts of the coastal western United States. In contrast, snowpack in
the coarser-resolution model is largely eliminated in the warmed
climate. Whether snowpack persists influences the regional surface
energy budget due to the snow-albedo feedback. The results highlight the
importance of resolving orographic precipitation and the large-scale
circulation response to warming in a consistent framework.
Occurrence of rare lightning events during Hurricane Nicholas (2021)
Authors: Logan Timothy , Hale Jacob , Butler Sydney , Lawrence Brendan , Gardner Samuel
Published: May 2024

Hurricane Nicholas was classified as a Category 1 tropical cyclone (TC)
at 0000 UTC on 14 September 2021 and made landfall along the upper Texas
Gulf Coast at 0530 UTC with maximum sustained winds of 33 m s-1. Much of
the electrical activity during Nicholas was monitored by the Houston
Lightning Mapping Array (HLMA) network. Deep convection developed in the
rainband at 1700 UTC on 13 September, diminished by 2030 UTC, and
re-intensified after 2200 UTC. At 2004 UTC (13 September), a curved
megaflash (~220 km) was observed by the HLMA in the
stratiform precipitation region of the outer rainband. By 0130 UTC on 14
September 2021, vigorous deep convective cells developed in the eastern
eyewall region and propagated cyclonically to the western eyewall
region. Several “jet-like” transient luminous events (TLEs) were
observed by the HLMA emanating from a deep convective cell in the
western eyewall region between 0230-0300 UTC with VHF source points
ranging from 30-45 km in altitude. Moreover, the TLEs occurred within a
region of strong wind shear, upper-level graupel-ice crystal collisions
(~15 km), and strong cloud top divergence. Charge
analysis of the deep convection during Nicholas revealed an overall
normal dipole structure, while the megaflash and TLE deep convective
cases exhibited inverted dipole charge structures. Dissipation of the
upper-level screening charge layer resulting from cloud top divergence
likely played a role in the observed TLE VHF sources escaping to
altitudes exceeding 30 km.
Video Modeling Combined with Self-Monitoring Strategies on Meal
Time Activities of an Elementary School Student with Intellectual
Disabilities
Authors: Shin Yu Jin , Paik Eunhee
Published: May 2024

The purpose of this study was to examine video modeling combined with
self-monitoring strategies on meal time activities which are meal preparation,
cleaning the table, tooth brushing skills of an elementary school student with
intellectual disabilities in a special school. The research questions were as
follows: First, does the video modeling combined with self-monitoring strategies
affect on meal time activities of an elementary school student with intellectual
disabilities? Secondly, does video modeling combined with self-monitoring affect
its maintenance and generalization of meal time activities for an elementary
school student with intellectual disabilities? One elementary school student
with intellectual disabilities, age 11, participated in the study. Multiple
probe design across behaviors were utilized for this study. The result of the
study were as follows: video modeling combined with self-monitoring improved the
meal time activities of the participant. The effects were maintained three weeks
after the intervention. The average of non-overlapping data point(PND) was 96%,
indicating a ‘high effective level’ of intervention effects. The result of this
study proved that video modeling combined with self-monitoring strategies was an
effective intervention enhancing meal time activities for an elementary school
student with intellectual disabilities. The results were maintained and
generalized at home.
The Effect of Multi-Component Behavioral Intervention Based on Life
Support-Oriented Individualized Education Plan (IEP) on the Out-of-Seat and
Task Performance Behaviors for Student with Intellectual
Disabilities
Authors: Kim Bo-Ram , Kim Hee-Jin , Jeong Ju-Young , Na Kyong-Eun
Published: May 2024

The purpose of this study was to investigate the effects of multi-component
behavioral interventions based on life support-oriented Individualized Education
Plan(IEP) on the out-of-seat and task performance behavior for student with
intellectual disabilities. The independent variable in this study was the
multi-component behavioral intervention based on a life support-oriented IEP,
and the dependent variables were out-of-seat behavior and task performance
behavior. The study was conducted using an AB design, consisting of baseline,
intervention, and maintenance phases. After establishing a life support-oriented
IEP in the research preparation stage, observers were trained, problem behavior
selection and functional behavior evaluation (FBA) were conducted, reinforcement
evaluation was conducted, and a behavioral intervention plan(BIP) based on life
support-oriented IEP was developed. Baseline, intervention, and maintenance
phases were conducted in special education classrooms, with data collection
occurring from 10 minutes after class started to 30 minutes afterward. Analyses
were conducted in terms of level, immediacy, trend, averages and ranges, and
Percentage of Non-overlapping Data(PND). Qualitative aspects of the dependent
variables were analyzed in-depth through anecdotal analysis. The results showed
that the multi-component behavioral intervention based on the life
support-oriented IEP was effective in reducing out-of-seat behavior and
increasing task performance behavior. These effects were maintained after the
intervention ended. Based on the results, implications were discussed with
limitations and suggestions for future research.
A Delphi survey on developing verbal behavior assessment tool for
autism spectrum children using ICF core set Autism Brief
Authors: Shin Byeolhae , Choi Jinhyeok
Published: May 2024

The purpose of this study is to develop a verbal behavior assessment tool for asd
children using ICF Core Set-Autism Children Brief and verify the validity. Two
rounds of Delphi survey on validity of items from IICF Core Set-Autism Children
Brief was undertaken by 9 panels who are professionals in applied behavior
analysis. As a result, 22 items were identified to be suitable among 48 items.
For developmental level suitability, pre-talking and watching were the most
suitable items for pre-listener level and listener level and speaker level were
found to share common items such as memory function, intellectual function, pay
attention, overall psychosocial functions. We discussed about implications that
verbal behavior assessment tool for asd children should consider based on the
results.
Influence of Invisalign precision bite ramp utilization on deep bite correction and root length in adults
Authors: Husain Fatemah , Warunek Stephen , Gurav Ashish , Giangreco Terry , Tanberg William , Al-Jewair Thikriat
Published: May 2024

Objectives

To assess the influence of Invisalign precision bite ramp use on skeletal deep overbite correction and root length and volume of maxillary anterior teeth.

Materials and Methods

This was a retrospective study of 60 adults with skeletal deep overbite. Patients were divided into three groups: Invisalign (Align Technology, San Jose, Calif) with precision bite ramps (Invisalign with Bite Ramps [IBR] = 12), Invisalign with no bite ramps (INBR = 22), and full-fixed appliances (FFA = 26). Cone beam computed tomography records at T1 (pretreatment) and T2 (posttreatment) were used to measure eight skeletal, nine dental, and three soft-tissue cephalometric variables. Maxillary anterior teeth root length (mm), root volume (mm3), and percent root volume loss between T1 and T2 (%) were also recorded.

Results

Significant changes from T1 to T2 among the three groups were seen in ANB(o), lower face height (%), ODI (overbite depth indicator) (o), and U1–SN (o). Reduction in root length was significantly less (P < .001) in the INBR and IBR groups compared to the FFA group. Reduction in root volume and percent volume loss were significantly higher in the INBR group compared to the IBR group (P < .001), but the difference between the two Invisalign groups and the FFA group was not significant.

Conclusions

Skeletal deep overbite correction using Invisalign with or without bite ramps is comparable to FFA. Reduction in root length was significantly less with Invisalign compared to FFA. Bite ramps influenced root volume and volume loss but not root length.
Nature Inspired Discovery and Development of Antibacterials: An Update
Authors: HC Upadhyay
Published: May 2024

The growing prevalence of pathogens resistant to several drugs poses an urgent health concern, which can only be addressed by increasing support for the research and development of newer antibiotics. Drug discovery through the exploration of nature's treasures is a successful and ongoing endeavor. However, the conventional method of discovering new drugs from natural sources has become an adjunct choice of the pharmaceutical corporations since it is time-consuming, complicated, expensive, and fraught with uncertainty. The application of several computational techniques, including combinatorial chemistry, metagenomics, and high throughput screening, has accelerated the drug development process simultaneously reducing costs and time. It is a well-established fact that synthetic drugs generated through computer-aided research are frequently linked to a restricted spectrum of pharmacological activity and adverse side effects as compared to treatments that are either directly or indirectly derived from natural sources. Hence, an innovative drug discovery program may be centered on the virtual design of molecules using a scaffold with a natural origin in order to develop effective and affordable therapies with a wide variety of functionality
Práxis na Construção de um Projeto Político Pedagógico Freireano
Authors: Lima Josenilda Assunção , Santos Jefferson da Silva , Solino Ana Paula , Gehlen Simoni Tormohlen
Published: May 2024

Neste estudo, foram analisadas as dimensões da práxis criadora e reflexiva na elaboração de um Projeto Político Pedagógico (PPP) pautado pela perspectiva freireana. Para tanto, foi realizado um curso de formação de educadoras, envolvendo a comunidade local e escolar do município, com foco na obtenção de Temas Geradores. As informações, obtidas por meio de videogravações dos encontros com moradores e educadoras, foram examinadas mediante a análise textual discursiva, com base nas categorias: a) A práxis reflexiva no processo de compreensão das demandas da comunidade do Iguape; b) A práxis criadora no trabalho coletivo de construção do PPP da Escola Padre Giuseppe Bonomi. Destaca-se que a práxis reflexiva e a criadora são indissociáveis em um PPP humanizador, pois estão relacionadas ao desenvolvimento da consciência dos sujeitos e à dialeticidade do trabalho coletivo entre escola e comunidade na superação de demandas locais.
Aprendizagem em fóruns da internet
Authors: Junqueira Eduardo S. , Barroso Diego Linhares Cruz Tabosa
Published: May 2024

O estudo investigou práticas de usuários de fóruns da internet na plataforma Reddit para compreender a natureza das interações nas trocas de mensagens. A partir do referencial da aprendizagem social como uma prática cultural, procedeu-se a uma análise para categorizar e compreender os tipos de mensagens e suas relações com a cultura dos fóruns e o desenvolvimento de novos conhecimentos. Para a codificação, foram utilizados três sistemas de classificação que resultaram em duas tipologias: mensagens típicas de fóruns, nem sempre associadas às temáticas, contendo piadas e memes, alinhadas a características do Reddit. E mensagens mais densas, relacionadas às temáticas, contendo trocas de informações e debates. A análise demonstrou um imbricamento entre a expansão de conhecimentos sobre temas abordados e o desenvolvimento de laços sociais típicos dos fóruns da internet, indicando a ocorrência da aprendizagem social.
Discurso da Adaptação ao “Novo Espírito do Neoliberalismo” na Base Nacional Comum Curricular para o Ensino Médio
Authors: Faria Clara Chaves Marques , Leal Sayonara de Amorim Gonçalves
Published: May 2024

A atual Reforma do Ensino Médio, aprovada pela Lei 13.415/2017, representa uma mudança estrutural da educação pública brasileira e se insere em um horizonte mais amplo de reformas adaptadas ao “novo espírito do neoliberalismo”, entendido como racionalidade preponderante da fase atual do capitalismo. Buscamos investigar as afinidades entre o discurso da reforma de 2017, em especial na Base Nacional Comum Curricular para o Ensino Médio, e a construção de uma subjetividade neoliberal na formação escolar. Apoiadas no método da Análise de Discurso, ancoramo-nos nas noções de “projeto de vida” e de “empreendedorismo” para analisar três recortes da Base, nos quais destacamos os pilares para uma pedagogia da adaptação do sujeito à máxima do “empreendedor de si”.
Percepções de consumidores em restaurantes Fast Food em Campos dos Goytacazes
Authors: Lima Juliana Damaris Candido de , Araujo Fábio Francisco de , Franca Paula Albuquerque Penna
Published: May 2024

O setor de serviços tem ganhado relevância na sociedade pós-industrial. Nesse contexto, o setor de serviços alimentício emerge com destaque na economia de vários países. Este trabalho tem como objetivo avaliar a qualidade de serviços em restaurantes fast food a partir do método de análise hierárquica, que facilita a interpretação de priorização em um problema decisório multicritério. Foi utilizado um questionário baseado na ferramenta DINESERV. Por meio de uma análise fatorial, as cinco dimensões originais foram reorganizadas em seis dimensões (critérios): Instalações Físicas, Cardápio, Decoração do ambiente e Aparência dos Funcionários; Confiabilidade; Responsividade, Segurança e Empatia. Os resultados mostram que os fatores que interferiram na preferência escolha dos consumidores são: Cardápio, Decoração do ambiente e Aparência dos Funcionários.
Framework Scrum aplicado na auditoria interna e o uso de dados para gestão de Sprints
Authors: Fernandes Welington , Lledo dos Santos Francisco
Published: May 2024

Gerenciar projetos é uma atividade cotidiana no ambiente de negócios, que precisa se adequar cada vez mais a um cenário de constante mudança. Metodologias ágeis têm ganhado espaço para essa gestão, porém, enquanto equipes de desenvolvimento de sistemas são adotantes comuns delas, outros tipos de equipes não são, como por exemplo a auditoria interna. Esse estudo aplicou a metodologia Scrum em um departamento de auditoria interna, e utilizou dados para trazer informações operacionais através de um dashboard. Dados também foram utilizados para fornecer previsibilidade para o planejamento e mensurar o desempenho do time. Por fim, foi comparado o resultado de indicadores do departamento, antes e após o Scrum, para verificar qual foi o impacto nesses indicadores pela adoção da metodologia.
pedra angular do arco
Authors: Dilworth David
Published: May 2024

A Naturphilosophie e a Freiheitsschrift de Schelling como proveniência do princípio fundamental do sinequismo de Peirce.
summum bonum digital
Authors: Bittencourt Levy Henrique
Published: May 2024

O objetivo desse trabalho é relacionar os três princípios, ou prazeres, estéticos de um videogame, isto é, imersão, agência, transformação, com o summum bonum e as categorias fenomenológicas de Charles S. Peirce. O summum bonum pode ser entendido como uma mistura entre sentimento, ação e razão. Os sentimentos, ações e pensamentos do jogador são responsáveis pela concretização e ampliação desse horizonte estético. A imersão é um princípio estético de primeiridade. Podemos entender o ato de imergir como um prazer de primeiridade – pois o jogador, metaforicamente e literalmente, vai para outro lugar, estando sem relação com o que está fora da imersão. O princípio estético da agência é regido pela secundidade. Obtém-se prazer em forçar-se contra o mundo do jogo, controlando-o mecanicamente, agindo e reagindo. Todos os jogos possuem secundidade, mas os jogos de competição, lutas, corridas, e mesmo alguns RPGs online, possuem características marcantes de força mecânica, embate, ação e reação. O terceiro e último princípio estético é a transformação. A transformação é um processo. Jogos que permitem diferentes abordagens costumam ser jogos em que há um processo de crescimento, tanto na questão do gameplay quanto da própria narrativa do jogo. O mundo do jogo e o personagem vão se transformando em algo diferente no decorrer do tempo – há uma evolução, e essa evolução é caracterizada como um fenômeno de terceiridade. Concluiu-se que, embora todos os videogames tenham esses três princípios estéticos, cada jogo individual privilegia um ou dois desses princípios. É justamente esses princípios estéticos que direcionarão a escolha do que vai ser jogado, muito mais do que a temática ou o gênero desse jogo.
Filosofia como caminho para a transformação
Authors: Fabbrichesi Rossella
Published: May 2024

No período antigo – grego e helenístico em particular – a filosofia era concebida não como uma atividade intelectual pura voltada para a busca da verdade, mas como um exercício prático de pensamento que deveria servir à vida e ter como objetivo a autotransformação. O objetivo era aprender a conduzir uma vida filosófica e a cuidar de si: principalmente de suas falas e ações. Não era tão importante poder expor uma doutrina verdadeira, mas sim colocar em prática os ensinamentos que eram dados. Esta perspectiva caduca já no período medieval, mas podemos perguntar-nos se a atitude pragmatista não reanima alguns dos seus aspectos: por exemplo, a enxertia da prática na teoria, a concepção de ideias como planos de ação, a referência a efeitos de verdade, e similar. Neste artigo pretendo testar esta hipótese, especialmente com referência ao estudo que Peirce realizou sobre o processo de “autocontrole” (os antigos diriam “autogoverno”, autarkeia) como base da ética, entendida como uma ciência normativa e o fundamento da lógica.
Cantar, sambar, curar e confirmar
Authors: Bonine Eduardo Goedert
Published: May 2024

A epistemologia de terreiro é uma metodologia e um lugar conceitual ainda em disputa na Ciência da Religião. Reconhecer esses espaços de brasilidade enquanto produtores de conhecimento e capazes de falar por si é um dos esforços que pretendemos com este artigo. A partir do fenômeno de Seu Sete da Lira, que bagunçou o conceito ortodoxo de espaço religioso, ao profanar o sagrado e sacralizar o profano, apresentaremos conceitos pertinentes para ampliar o diálogo dentro de nossa disciplina. O devir macumbeiro e a circularidade cultural são duas categorias que podem oferecer outros caminhos e outras possibilidades na produção de nossa ciência.
Numerical analysis of thermal differential distribution in Bobbin tool friction stir welding of 7075-AZ31B dissimilar alloy
Authors: Liu Y. , Chen K. , Zeng G. , Wang Z. , Ge M. , Zang Y.
Published: May 2024

The theoretical model of bobbin tool friction stir welding (BT-FSW) structure and dynamic process is established. Because of the great differences in properties of different materials, the mathematical relationship between material stress and deformation will be expressed based on 3D transient heat conduction equation and J-C constitutive model. The BT-FSW process of 7075 and AZ31B was analyzed by finite element method, and the field distribution, thermal cycle curve and stress distribution characteristics of different welding areas of the welded material were simulated. To predict and control the non-equilibrium distribution of welding temperature and stress field, the influences of different Rotating speed, welding speed, offset and other variables on the BT-FSW process of 7075/AZ31B aluminum magnesium dissimilar alloy were studied comprehensively. Finally, the reliability of the model is proved by fitting the experimental and numerical analysis results. The research results show that the temperature of BT-FSW presents an “hourglass” symmetrical distribution, and the stress distribution on both sides of the plate is uniform when the aluminum alloy is placed on the advancing side, the stirring tool is offset to the aluminum alloy by 2mm, and the rotating speed and welding speed are 700r/min and 180mm/min, respectively.
Giant Intracranial Aneurysms in Infants: Case Report and Review of the Literature
Authors: Haouass Mohammed Yassine , Lahlou Salma , Hmada Saad , Hilmani Said , Ibahioin Khadija , Bertal Abderrazak , Lakhdar Abdelkrim
Published: May 2024

Intracranial aneurysms are extremely rare in infants and differ from those in adults in their mode of presentation, location, size, and long-term outcome. Their treatment is very complex. Our case is a 24-month-old infant who featured a giant aneurysm of the basilar trunk diagnosed at the age of 04 months by an alternate syndrome of sudden onset, with a follow-up for 2 years. Therapeutic management is much discussed between surgical treatment, endovascular treatment, and therapeutic abstention which depends on the age, location, size, and mode of installation of these aneurysms.
A Comprehensive Analysis of Flooding Mechanisms Along Crasna River
Authors:   JBA Consult Europe, Bucharest, Romania e-mail: cristina.rizea@jbaconsulting.ro, RIZEA Cristina , SABĂU Daniel ,   Somes-Tisa Water Basin Administration, Cluj-Napoca, Romania, VOICU Silvia ,   JBA Consult Europe, Bucharest, Romania, TEODORESCU (DAN) Marinela ,   JBA Consult Europe, Bucharest, Romania
Published: May 2024

Across the world best practice, the flood hazard and risk maps are core instruments used for the development and implementation of flood management policies. These maps sit as base information for developing flood management strategies and plans, designing of new flood defence schemes and assessment of the existing flood scheme performance, elaboration of emergency and action plans, territorial planning (zoning and permissions), land use control, climate changes impacts evaluation, insurance industry etc. Romania did remarkable steps in developing high quality flood hazard and risk maps as core action for an integrated flood risk management. In the second cycle of Floods Directive 2007/60/EC implementation, Romania developed and reported to European Commission (EC) the hazard and risk maps for 526 APSFRs (Areas with Potential Significant Flood Risk). The hazard maps built in second cycle are the result of detailed models developed based on high resolution Lidar (0.5m), calibrated hydrological data and advanced modelling technics. Crasna River is one of the watercourses from the Somes-Tisa Basin which benefited from advanced 2D hydraulic modelling having in-place all the existing infrastructure and which has been well - calibrated on the flood event recorded in 2015. The calibration of the model on 2015 flood event was performed both for flows and levels. The article aims to explicitly present the performance of the existing defence system of Crasna river during extreme flood events with different magnitudes having in hand these high-quality hydraulic model and hazard maps.
Urban Pluvial Flood Risk in Romania, in the Context of Floods Directive Implementation
Authors:   JBA Consult Europe, Email: tom.sampson@jbaconsulting.com, SAMPSON T. , RĂDULESCU D. ,   JBA Consult Europe, Bucharest, Romania, ION M.B. ,   JBA Consult Europe, Bucharest, Romania, COZMA A. ,   JBA Consult Europe, Bucharest, Romania
Published: May 2024

Romania is a flood prone country and same are her cities. Pluvial floods can occur in urban or rural areas without a direct connection with river or a water body. As part of the Floods Directive implementation, Romania has identified, in the first cycle, a number of 17 urban areas with a significant pluvial flood risk potential. For every urban area identified, flood hazard and flood risk maps have been developed. Based on this, the present paper tries to present some of the main risk receptors, that could give an insight related to the level of risk at which the urban areas are exposed. What is the quantitative risk profile of this cities, what can be done further to mitigate this risk and are there any other urban areas at risk of pluvial flooding? The present paper seeks to provide an answer at the above questions and present potential solutions for pluvial risk reduction.
Synoptic and Climatological Analysis of Autumn 2023 from the Perspective of a Meteorologist Forecaster
Authors:   Forecarsters meteorologist CMR Oltenia, SFÎRLEAZĂ Fania , POPA Adriana ,   Forecarsters meteorologist CMR Oltenia, BĂCESCU Adriana ,   Forecarsters meteorologist CMR Oltenia
Published: May 2024

The fall of 2023 was atypical both in terms of recorded temperatures and accumulated precipitation. September and October retained many characteristics of an authentic summer, with this year experiencing up to 22 summer days, 16 tropical days, and 3 heatwave days. The weather conditions this autumn were influenced by the atypical position and evolution of baric centers, as well as the warm advection at the 500hPa level