bluuebunny/crossref_metadata_2025 huggingface dataset:
Alterations of resting-state functional network connectivity in patients with noise-induced hearing loss: a study based on independent component analysis
Authors: Ranran Huang , Aijie Wang , Yi Lin , Xinru Ba , Xianghua Bao , Yunxin Li , Yafei Zhang , Guochao Li , Guowei Zhang
Published: September 2023

Objective: To evaluate resting-state functional network connectivity
(FNC) alterations in patients with occupational noise-induced hearing
loss (NIHL) using an independent component analysis (ICA). Method: 79
mild NIHL patients (MP), 32 relatively severe NIHL patients (RSP), and
84 age- and education-matched healthy controls (HC) were recruited. All
subjects were tested using the Mini-mental State Examination scale test
(MMSE) and scanned by T1WI3DFSPGR, resting-state functional magnetic
resonance imaging (RS-fMRI) sequence and analyzed by the ICA. All
patients were tested using the tinnitus handicap inventory scale (THI)
and the Hamilton Anxiety scale test (HAMA). Result: Using the ICA, 7
resting-state networks (RSNs) were identified, and FNCs were compared
among the three groups. Compared with the HC, the MP showed increased
FNC within the executive control network (ECN) and enhanced FNC within
the default mode network (DMN) and the visual network (VN). Compared
with the HC, the RSP showed decreased FNC within the ECN and auditory
network (AUN), DMN and VN. No significant changes in FNC were found in
the MP compared with the RSP. Furthermore, the correlation analysis
between the noise exposure time and hearing loss level and the exposure
time and HAMA scores were both negative, and there were no significant
correlation between the FNC correlation coefficient of the abnormal RSNs
and the hearing level, noise exposure time, and HAMA. Conclusion: These
findings indicate that different degrees of NIHL involve different
alterations in RSNs connectivity, and may reveal the neural mechanisms
related to emotion-related features and functional abnormalities
following long-term NIHL.
Exploratory Study of Long-Term Neuropsychological Behavioural Outcomes of Children with Traumatic Brain Injury
Authors: Saidin Fariza
Published: September 2023

Numerous detrimental consequences follow traumatic brain injuries (TBI)
in youngsters. According to research, TBIs are more expected to cause
cognitive deficits, behavioural issues, poor academic performance, and a
loss in adaptive behaviour, especially in progenies who have agonized
more serious injuries. This study observed at early children with
difficult slight to severe traumatic brain injury (TBI) respond to
treatment for their behavioural issues and social skill deficiencies.
The current study watched varying levels of brain-derived neurotrophic
factor (BDNF) affected Neuropsychological Functioning (NF) in kids who
had suffered TBI. The data gathered during a prospective observational
study of children were subjected to a secondary cross-sectional
analysis. This gives details on the age-specific range of
neuropsychological outcomes for families who have ached TBI and more
accurately defines the NF of kids in both age groups who are categorized
as having positive results. Accordingly, the study considers that
pre-injury cognitive and behavioural problems can exacerbate post-injury
outcomes. This study reveals that near is a confident correlation
between emotional suffering and behavioural problem, parental burden and
injury severity, Psychological Distress (PD) and injury severity, and
behavioural problems and injury severity. This research also showed that
the family environment would affect damage severity in a way that would
increase the effects of TBI on children’s social functioning. Therefore,
understanding the nature of persistent behavioural issues will be
beneficial for clinicians who provide post-injury rehabilitation
services and generate TBI intervention strategies.
The HPV viral regulatory mechanism of TLRs and the Related treatments for HPV-Associated Cancers
Authors: Deng Shou-Long , Qi si-yu , liu yixun , Yang Minghui , Yu Kun , lian zhengxing
Published: September 2023

Infection with human papillomavirus (HPV) typically leads to cervical
cancer, skin related cancers and many other tumors. HPV is mainly
responsible for evading immune tumor monitoring in HPV related cancers.
Toll like receptors (TLRs) are particular pattern recognition molecules.
When the body is facing immune danger, it can lead to innate and direct
adaptive immunity. TLR plays an important role in initiating antiviral
immune responses. HPV can affect the expression level of TLR and
interfere with TLR related signaling pathways, resulting in sustained
viral infection and even carcinogenesis. This paper introduces the HPV
virus and HPV related cancers. We discussed the present comprehension of
TLR, its expression and signaling, as well as its role in HPV infection.
We also provided a detailed introduction to immunotherapy methods for
HPV related diseases based on TLR agonists. This will provide insights
into methods that support the therapeutic method of HPV related
conditions with TLR agonists.
Drug repurposing screen targeting PARP identifies cytotoxic activity of efavirenz in high-grade serous ovarian cancer
Authors: Matthews Bayley , Wong-Brown Michelle , Liu Dongli , Yee Christine , Dickson Kristie-Ann , Schneider Jennifer , Islam Saiful , Head Richard , Martin Jennifer , Ford Caroline , Marsh Deborah , Bowden Nikola
Published: September 2023

Background and Purpose: Drug repurposing has potential to improve the
care for treatment resistant high-grade serous ovarian cancer (HGSOC).
We hypothesised that broadly targeting PARP for drug repurposing would
elicit cytotoxic responses in HGSOC through multiple biological
processes. Experimental Approach: in-silico ligand-based virtual
screening BLAZE was used to identify drugs with potential PARP-binding
activity. The list was refined by dosing and known cytotoxicity,
lipophilicity, teratogenicity, and side effects. The highest ranked
drug, efavirenz, progressed to in vitro testing. Eight HGSOC cell lines
were used to determine the IC50 for efavirenz. To determine the
cytotoxic effects of efavirenz in a more physiologically relevant model,
3D hydrogel-encapsulated models of HGSOC and patient-derived organoid
models of HGSOC were established. Live-cell imaging was employed to
quantify apoptosis and cell death. Western blots, cell cycle analysis
and PARP activity assays were performed to determine whether PARP1
enzyme expression and activity was inhibited following efavirenz
treatment. Key Results: IC50 for efavirenz was 25.02-46.28µM for cells
grown in 2D. After 7 days, IC50 doses of efavirenz reduced cell
confluency and induced cell death and apoptosis. IC50 values for
efavirenz in 3D models were higher ranging from 27.8-55.11µM, and in
four HGSOC patient-derived organoids ranged from 14.52-42.27µM.
Interestingly, COV362 cells that have a BRCA1 mutation and HRD,
displayed the highest IC50 to efavirenz in both 2D and 3D models. The
percentage of cells in sub-G1 and G1 phase increased after 35µM and 45µM
doses of efavirenz, indicating an increase in stalling in G1.
Conclusions and Implications: Efavirenz may be a viable therapeutic
option for HGSOC independent of HRD
The new prospectives of statins in combination therapies for ovarian cancer based on connections of mechanisms
Authors: Zhang Xinya , Zou Yuliang
Published: September 2023

Epithelial ovarian cancer is a disease with the highest mortality rate
among gynecological tumors. After years of studies, despite targeted
drugs and immunotherapies have been developing, their therapeutic
effects are still not ideal. Statins, as lipid-lowering medicines, have
many findings beyond expectation in the fight against cancer, and have
shown promisingly positive results in clinical trials. Actually, statins
cannot be used as a monotherapy to achieve complete remission due to its
efficacy established, but for its great potential lying in effects about
synergism and sensibilization with other drugs, and even the reduction
of side effects of anti-cancer treatment. This review summarizes the
evidence and potential of combining statins with first-line
chemotherapy, bevacizumab, PARP inhibitors and immunotherapy drugs in
the pharmacotherapy of ovarian cancer, and proposes hypothesises about
new combination therapies based on the current mechanisms and theories,
to provide a new perspective to further experimental research and
clinical trials.
The global pyrogeography of ecoregion flammability thresholds
Authors: Ellis Todd , Bowman David , Williamson Grant
Published: September 2023

Anthropogenic climate change is creating a more flammable future by
increasing the number of days when vegetation is dry enough to burn.
Indices representing the percent moisture content of dead fine fuels as
derived from meteorological data have been used to assess geographic
patterns and temporal trends in vegetation flammability. To date, this
approach has assumed a single flammability threshold, typically between
8 and 12%, controlling fire potential regardless of the vegetation type
or climate domain. Here we investigate geographic variation in fuel
moisture levels associated with observed fire activity among ecoregions
by analysing global reanalysis data and remotely sensed burnt area
products. This geospatial analysis identified a wide range of ecoregion
flammability thresholds (EFTs) associated with fire activity, often well
above or below the commonly used range of values. Many boreal and
temperate forests, for example, can burn with much higher fuel moisture
than previously identified; Mediterranean forests, on the other hand,
tend to burn with consistently low fuel moisture. Bayesian modelling
showed that EFTs are primarily driven by eco-climatological variables,
particularly precipitation and temperature. Our analysis also identified
complex associations between vegetation structure, fuel types, and
climatic conditions highlighting the complexity in
vegetation-climate-fire relationships globally. Our study provides a
critical, necessary step in understanding and describing global
pyrogeography and tracking changes in spatiotemporal fire activity.
Acute Abdomen Following COVID-19 Vaccination. A Systematic Review.
Authors: Cahuapaza-Gutierrez Nelson , Pajuelo-Vasquez Renzo , Quiroz-Narvaez Cristina , Rioja-Torres Flavia , Quispe-Andahua María , Runzer-Colmenares Fernando
Published: September 2023

Aims: Conduct a systematic review of case reports and case series
regarding the development of acute abdomen following vaccination with
COVID-19, to describe in detail the possible association, the clinical
and demographic characteristics. Methods: Case report studies and case
series regarding the development of acute abdomen following COVID-19
vaccination were included. Systematic review studies, literature,
letters to the editor, brief comments, etc. were excluded. PubMed,
Scopus, EMBASE, and Web of Science databases were searched until June
15, 2023. The Joanna Brigs Institute tool was used to assess risk of
bias and study quality. Descriptive data were expressed as frequency,
median, mean, and standard deviation. Results: Seventeen clinical case
studies were identified and 17 patients with acute abdomen associated
with COVID-19 vaccination were evaluated, including: acute appendicitis
(n=3), acute pancreatitis (n=9), diverticulitis (n=1), cholecystitis
(n=2) and colitis (n=2). The most associated COVID-19 vaccine was
Pfizer-BioNTech (mRNA) with 64.71 %. The majority of cases acute
abdomen was after the first dose (52.94 %). All patients responded
objectively to medical (88.34 %) and surgical (11.76 %) treatment and
were discharged within a few weeks. There were no cases of death.
Conclusions: Acute abdomen is a rare complication of great interest in
the medical and surgical practice of COVID-19 vaccination, our study
reviewed based on a small sample of patients, therefore it is
recommended to conduct future observational studies and fully elucidate
the mechanisms by which this association occurs.
Comparing SMOTE-based-ML Methods on the unbalanced dataset: A case study on a date and pistachio fruits
Authors: Bal Fatih , Kayaalp Fatih
Published: September 2023

The use of artificial intelligence (AI) techniques in agriculture has
reached a critical point, and classification studies utilizing machine
learning (ML) methods for agricultural products are being conducted
intensively. However, these studies face challenges in creating balanced
datasets, which can significantly impact the performance of proposed
methods and lead to confusing results. In this study, we address this
challenge by creating a dataset comprising data from 7 species of date
palm (Phoenix dactylifera L.) and 2 species of pistachio fruit (Pistacia
vera L). Our objective is to evaluate the performance of ML methods on
this dataset and explore the effectiveness of the Synthetic Minority
Over-Sampling Technique (SMOTE) for improving classification accuracy.
Initially, we performed classification on the original dataset using
popular ML methods. Among these methods, the POLY-SVM model exhibited
the best performance with an accuracy ratio of 92.95%. However, we
observed limitations in the classification results due to the unbalanced
distribution of data among different classes. To address this issue, we
applied the SMOTE technique for over-sampling, which effectively
balanced the data distribution. The POLY-SVM model, when trained on the
dataset after SMOTE over-sampling, achieved a significantly improved
classification accuracy of 98.64%. Furthermore, our proposed model
demonstrated enhanced sub-classification performance, particularly for
fruit species. In conclusion, this study highlights the challenges posed
by unbalanced data distribution in agricultural product classification
studies using ML methods. By utilizing the SMOTE technique for data
over-sampling, we successfully addressed this challenge and improved
classification accuracy.
EPIDEMIOLOGY OF PAEDIATRIC TRAUMA DURING NATIONAL LOCKDOWN: LESSONS FOR THE FUTURE. A RETROSPECTIVE STUDY WITH 12 MONTHS FOLLOW-UP
Authors: Qin Catherine , Tamang Rupen , Waugh Dominic , Grayston James , Al-Ashqar Mohammad , Bakhshayesh Peyman , Deriu Laura
Published: September 2023

Introduction: National lockdown was implemented to slow down the
COVID-19 outbreak. This paper aims to compare the epidemiology of
paediatric orthopaedic trauma presentation, management and outcomes
during the lockdown period with the matched pre-pandemic period in 2019.
Methods: This was a retrospective cohort study. All patients aged 0 - 18
years who required trauma unit management during the school closure
period (18 March – 25 May 2020) were included. Cases for the matched
period in 2019 were analysed for comparison. Patient demographics,
mechanism and anatomic location of injury, management, and follow-up
were assessed. Results: 286 and 575 injuries were observed in 2020 and
2019, respectively. In 2020, we observed a 50.3% fall in paediatric
trauma presentation. There was a significant reduction in the average
age at presentation by more than one year (p < 0.001).
Sports-related injuries decreased significantly (n=16 5.6% vs n=127
22.1%; p<0.001). Proportion of ride on injuries increased
significantly (n=63 22% vs n=61 10.6%; p<0.0001).
Non-accidental injury concerns rose significantly (n=9 3.1% vs n=4
0.7%; p=0.01). There was a proportional increase in upper limb injuries
(64.3% vs 58.4%) and proportional reduction in lower limb injuries
(32.1% vs 35.5%). Use of conservative management increased. Telephone
follow-up rose significantly (23% vs 6%; p < 0.001).
Re-presentation rate increased significantly (1.4% vs 0.2%; p = 0.04).
Conclusion: There was a reduction in paediatric trauma presentation and
the average age at presentation during lockdown. This change was
accompanied by a shift in mechanism and anatomic location of injury,
management, and follow-up.
Aktív surveillance a gyakorlatban – összefoglaló közlemény
Authors: Beöthe Tamás Zsolt
Published: September 2023

Az aktív surveillance (AS) kihasználja a prosztatarák elhúzódó természetes lefolyását. Az aktív kezeléseket halasztják, a beteg szigorú protokoll szerint ellenőrzés alatt áll. Progreszszió esetén a kuratív kezelés még akkor történik meg, amikor a beteg biztonságosan meggyógyítható. A cél a kezeléssel kapcsolatos toxicitás minimalizálása a túlélés veszélyeztetése nélkül. Az AS alkalmazhatóságát és biztonságát több vizsgálat igazolta, azonban a vizsgálatok heterogenitása miatt a szakmai irányelvek részben konszenzusra támaszkodnak. Az alacsony kockázatú betegségben szenvedő és 10 év feletti várható élettartamú betegeknél az AS-t standard, elsőként választandó kezelésnek kell tekinteni. AS akkor ajánlható, ha ISUP 2 daganat mellett a prosztataspecifikus antigén (PSA) <10 ng/ml, a klinikai stádium <T2a, a daganat kis kiterjedésű, és alacsony a pozitív minták száma. A PSA értéke 20 ng/ml-ig elfogadható lehet, ha a PSA-denzitás alacsony. ISUP 3 vagy kedvezőtlen szövettani eredmény – mint pl. cribriform mintázat, ductalis karcinóma – kizáró tényezők. A követés során rektális digitális vizsgálat (legalább évente) és PSA-vizsgálat elvégzése (legalább 6 havonta), valamint a biopszia rendszeres ismétlése is javasolt. PSA-emelkedés vagy egyéb (pl. multiparametrikus MRI) gyanú esetén szövettani mintavétel szükséges. Aktív terápiára váltás indoka elsősorban a Gleason-érték emelkedése vagy a daganat területének növekedése. A beteg bármikor dönthet aktív kezelés mellett. Ha az életkilátások 10 évnél rövidebbek, „figyelmes várakozás” javasolt. Kiemelendő a felvilágosítás fontossága, a terápiás döntésbe az onkoteammel együtt a beteget is be kell vonni.
Új utak a prosztatarák terápiájában: a genetikai mintázat szerepe a célzott kezelések kiválasztásában
Authors: Fazekas Tamás , Dér Bálint , Csizmarik Anita , Soós Áron , Fekete Bálint , Nyirády Péter , Szarvas Tibor
Published: September 2023

A prosztatarák genetikai tesztelésének használata egyre elterjedtebb a klinikai gyakorlatban. Ez elsősorban a PARP-inhibitorok megjelenésének köszönhető, amelyek a prosztataráknak a BRCA és más homológ rekombinációs javító (HRR) gének patogén eltéréseit hordozó eseteiben alkalmazhatóak. Ebből kifolyólag a genetikai vizsgálatok elvégzése a prosztatarák előrehaladott eseteinek kezelése során bekerült a rutinvizsgálatok közé. Ezzel párhuzamosan folyamatosan nő az olyan gyógyszeres kezeléseknek a száma, amelyek alkalmazása célzottan egy bizonyos genetikai eltérés jelenléte esetén lehetséges. Ennek eredményeképpen egyre növekszik azon gének száma, amelyek vizsgálata fontos lehet a prosztatadaganatok kezelési stratégiáinak megválasztásánál. Jelen közleményünkkel szeretnénk áttekintést nyújtani a prosztatarák molekuláris alcsoportjairól, valamint azokról a génekről, amelyek a jelenleg és a közeljövőben potenciálisan alkalmazható kezelések kiválasztásához szükségesek.
A prosztatarák szűrése
Authors: Szalontai János , Horváth András , Riesz Péter , Szűcs Miklós , Nyirády Péter
Published: September 2023

A prosztatarák az egyik leggyakoribb, ennélfogva az egyik legjelentősebb daganatos megbetegedés a férfiak körében. Ezen összefoglalóban az epidemiológiai és az etiológiai adatok mellett részletesen kitérünk a szűrésben leginkább használt prosztataspecifikus antigén legfontosabb ismérveire és azokra a további markerekre, amelyek segíthetnek diagnosztizálni a betegséget. Bemutatjuk azokat a fajsúlyos nemzetközi és magyar tanulmányokat, amelyek a prosztatarák szűrésével foglalkoznak.
A prosztatarák patológiája
Authors: Székely Eszter , Borka Katalin
Published: September 2023

A prosztata szövettani mintáinak vizsgálata (tűbiopsziás minták és eltávolított prosztataszövet), patológiai lelete nagyban befolyásolja a prosztatarákban szenvedő páciens kezelési stratégiáját. A daganat jelenlétének igazolása mellett kiemelkedő jelentőségű a szövettani típus meghatározása, a tumor kiterjedtségének megítélése, valamint bizonyos esetekben az egyértelműen felismerhető extraprosztatikus terjedés meghatározása. Ez az áttekintés a legújabb WHO-klasszifikáció alapján összefoglalja a meglévő szakirodalmat, valamint a prosztatakarcinóma osztályozását és prognosztizálását alátámasztó morfológiai és molekuláris adatokat.
IL-6 trans-signaling is increased in diabetes, impacted by glucolipotoxicity and associated with liver stiffness and fibrosis in fatty liver disease
Authors: Gunes Aysim , Schmitt Clémence , Bilodeau Laurent , Huet Catherine , Belblidia Assia , Baldwin Cindy , Giard Jeanne-Marie , Biertho Laurent , Lafortune Annie , Yves Couture Christian , Cheung Angela , N Nguyen Bich , Galun Eithan , Bémeur Chantal , Bilodeau Marc , Laplante Mathieu , Tang An , Faraj May , L. Estall Jennifer
Published: September 2023

Many people living with diabetes also have non-alcoholic fatty liver disease (NAFLD). Interleukin-6 (IL-6) is involved in both diseases, interacting with both membrane-bound (classical) and circulating soluble receptors (trans-signaling). We investigated whether secretion of IL-6 trans-signaling co-receptors are altered in NAFLD by diabetes, and whether this might associate with the severity of fatty liver disease. Secretion patterns were investigated using human hepatocyte, stellate and monocyte cell lines. Associations with liver pathology were investigated in two patient cohorts: 1) biopsy-confirmed NASH and 2) class 3 obesity. We found that exposure of stellate cells to high glucose and palmitate increased IL-6 and sgp130 secretion. In line with this, plasma sgp130 in both patient cohorts positively correlated with HbA1c, and subjects with diabetes had higher circulating levels of IL-6 and trans-signaling co-receptors. Plasma sgp130 strongly correlated with liver stiffness and was significantly increased in subjects with F4 fibrosis stage. Monocyte activation was associated with reduced sIL-6R secretion. These data suggest that the hyperglycemia and hyperlipidemia can directly impact IL-6 trans-signaling, and that this may be linked to enhanced severity of NAFLD in patients with concomitant diabetes.
Pengaruh Sinar UV-C terhadap Perubahan Mutu Wortel (Daucus carota L.) Selama Penyimpanan
Authors: Ningsih Nesti Kurnia , Novita Dwi Dian , Tamrin Tamrin
Published: September 2023

Based on the survey result of vegetable crop production in Indonesia, the national carrot harvest area is 13,398 hectares spread over 16 provinces.  Meanwhile, the average carrot production in Lampung Province can reach 16,02 tons/year with a harvested area of 369 hectares (BPS, 2018).  Damage to horticultura commodities can occur if the post-harvest handling is not done well.  Many problems were found related to the decay of agricultural products due to the development of microorganisms which caused gread losses for farmers. Sterilization with UV lamps is an attempt to kill and eliminate pathogens or spoilage microbes that cause food spoilage. This sterilization aims to determine the effect of UV-C rays on the quality of carrot during storage. This research was conducted using a completely randomized design (CRD) with 2 factors, namely the irradiation distance factor (20 cm, 40 cm, and 60 cm) and the irradiation time (1-, 20, and 30 minutes). The data obtained were analyzed by ANOVA test. In the 60 cm irradiation distance treatment with an irradiation time of 30 minutes is the recommended storage distance because it can suppress root growth with an average value of 16,67 %, physical damage 14,58%, and gives the panelists the best assessment of the freshness level parameter with an average value of 3,24 (scale 5), texture with an average value of 3,25 (scale 5), and skin appearance with an average value of 3,15 (scale 5). Keywords: Carrots, Microbes, Influence, UV-C Rays, Radiation
Dental implantlar için farklı yüzey modifikasyon tekniklerinin titanyumun yüzey özelliklerine etkilerinin karşılaştırılması
Authors: KIRMAN Mustafa , DİKİCİ Tuncay , DOĞAN Halit
Published: September 2023

Dental implantlarda en fazla kullanılan malzeme olan titanyumun yüzey morfolojisinin geliştirilmesi konusu birçok araştırmacının ve üretici firmaların üzerinde çalıştığı önemli konulardan biridir. Titanyumun biyouyumluluğu, üstün mekanik özellikleri, korozyon direnci ve osseointegrasyondaki başarısı biyomedikal uygulamalarda yoğun olarak kullanılmasının sebeplerindendir. Bu konuda yürütülen çalışmalar, implantın kemik ile olan etkileşiminde yüzey morfolijisinin doğrudan etkili olduğunu göstermiştir. Aynı zamanda implant malzemenin yüzey pürüzlülüğü, kimyasal bileşimi ve ıslanabilirliği de iyileşme aşamasında önemli rol oynar. Bu çalışma kapsamında saf titanyuma; kumlama, dağlama ve iki farklı çözelti ve voltajda anotlama olmak üzere toplamda dört farklı yüzey modifikasyon işlemi uygulanmıştır. Yüzeyi işleme tabi tutulan titanyum numunelerin, osseointegrasyonda önemli rol oynayan özelliklerden olan yüzey morfolojisi, faz yapısı ve yüzey pürüzlülük değerleri incelenmiştir. Dört farklı yüzey uygulamasının sonucunda yüzey morfolojileri başta olmak üzere farklı yüzey pürüzlülük sonuçları ve faz yapıları gözlemlenmiştir.
Textbook development strategy on the field of clothing life of the Practical Arts in the 2022 revised curriculum
Authors:   The Korean Association of Practical Arts Education, Jung Ji-yoon , Lee Yun-jung , Cho Youn-joo , Choi Kyeong-eun
Published: September 2023

The results of the study on the content composition and development strategy of the field of
clothing life of Practical Arts in the 2022 revised curriculum are as follows.
In the 2022 revised curriculum, there are 7 achievement standards in the field of clothing, 4
achievement standards that describe only the educational content in the field of clothing, and 3
achievement standards that describe the life of food⋅clothing⋅housing and in particular, the
achievement standards that are described by integrating the life of food⋅clothing⋅housing in the
explanation of the achievement standards must include clothing management and recycling when
developing textbooks.
As a textbook development strategy in the field of clothing life in the Practical arts of the 2022
revised curriculum, the area of 'human development and proactive life' is linked to self-direction,
democratic citizenship education, digital and AI literacy cultivation education, ecological
transformation education, and career education. In addition, in the area of 'Living Environment and
Sustainable Choice', 'Principles of Organizing Clothing Supplies and Making Clothing Supplies' are
linked to improvement of hand operation skills, procedural thinking, problem-solving skills,
creativity, emotional empathy, ecological transformation education, democratic citizenship education,
digital and AI literacy, and environmental protection and safety education. In addition, 'sustainable
clothing management' is linked to the cultivation of self-reliance capacity, sustainable clothing life
education, ecological transformation education, and democratic citizenship education.
Examples of textbook development strategy in the field of clothing life in the Practical arts of
the 2022 revised curriculum are ‘Making clothing supplies using hand sewing’ in the area of
‘Living environment and sustainable choice’. In addition, activities such as making pockets, purses,
bags, cushions, needle holders, cup mat, and keychains using fabric, felt, leftover fabric, or clothes
that are not worn are suggested.
The Effect of a Green Interior Horticultural Education Program on Plant Familiarity and Aesthetic Awareness of Elementary School Students
Authors:   The Korean Association of Practical Arts Education, Chung Ki-La , Kwack Hye-Ran , Im Eun-Ae
Published: September 2023

This study collected and analyzed data concerning green interior education by examining the
2015 Revised National Art and Practical Arts Curriculum, previous research, related books, and
online resources. Subsequently, it determined the direction for a model green interior horticultural
education program. The development of this education program was structured around two main
components: indoor gardening techniques and design principles for green interior spaces. This
approach was chosen to ensure a well-balanced learning experience. Related class activity maps
were created and provided as part of the program. With this framework in place, the study sought
to assess the program's impact on students' familiarity with plants and their aesthetic awareness. The
subjects of this study were two 5th-grade classes at J Elementary School, located in Seoul. The
students were assigned to the experimental and control groups and participated in 18 sessions of the
horticultural education program. The results indicated a statistically significant difference between the
two groups, demonstrating the effectiveness of the developed green interior horticultural education
program in improving elementary school students' familiarity with plants and their aesthetic
awareness. This implies that engaging in various activities centered around indoor plants as well as
experiencing the design and aesthetic elements of living spaces, yielded significant results. In
particular, green interior education, which integrates the two aforementioned domains, underscores
the psychological stability and significance of green space by transforming an actual living space
into a nature-friendly space and fosters an appreciation for aesthetic beauty through education on
indoor design. The study’s findings are expected to serve as foundational data for developing
teaching and learning materials for green interior experiences
Elementary pre-service teachers' ambivalent views on the introduction of artificial intelligence education: photovoice analysis
Authors:   The Korean Association of Practical Arts Education, Moon Daeyoung
Published: September 2023

This study aimed to investigate the ambivalent views held by pre-service elementary school
teachers regarding the introduction of artificial intelligence education using photovoice. The analysis
was conducted on a total of 116 photographs and accompanying descriptions, which were carefully
selected and contextualized by four of the 29 research participants. The findings can be summarized
as follows.
First, supportive views regarding the introduction of AI education were derived from seven
themes: 1) The familiarity of students with the digital environment, 2) The responsibility of the
school education system to prepare students for future society, 3) Opportunities to overcome the
limitations of existing teaching methods, 4) The potential of AI as an effective learning tool, 5)
The potential for customization of classes and feedback, 6) The potential of AI to spark interest in
learning by integrating with the digital learning environment, and 7) The role of AI in providing
teaching support and assistance to teachers.
Second, opposing views on the introduction of AI education were derived from the following
eight themes: 1) Concerns about AI's appropriateness for the development stage of elementary
school students, 2) Unpredictable risks and potential side effects, 3) AI’s limitations in fostering a
complete learning process, 4) Limitations of the value of direct experience, 5) Emphasis on the
importance of teaching value judgment and critical thinking skills prior to AI integration, 6) Fears
of losing human relationships, communication skills, empathy, and community spirit, 7) Belief that
AI cannot replace professional expertise and assistance provided by teachers, and 8) Reduced
thinking skills due to dependency on AI.
Third, the study delved into the ambivalent views surrounding the introduction of AI education
by interpreting the pros and cons perceived by pre-service elementary school teachers. These
ambivalent perspectives were analyzed from the standpoint of their implications for students,
teachers, the teaching and learning process, and society at large.
重審中醫瘟疫理論在當代疫情危機中的認知價值和倫理效應
Authors: 程 國斌
Published: September 2023

LANGUAGE NOTE | Document text in Chinese; abstract also in English.

在對中國古代瘟疫理論和公共衛生的研究中，往往認為傳統中醫學的傳染觀念和瘟疫理論不夠＂科學”和＂精准”，在公共衛生和社會防疫等中觀維度上無法發揮積極作用。但中醫學瘟疫理論，將疫情描述為彌漫性環境風險與人類活動相互作用的動態圖景，不僅具有在特定社會歷史環境和時人認知觀念背景下的時代合理性，相較於現代傳染病學＂傳染鏈”的線性分析模型，對當今疫情也能夠給出一個更具整體性的風險認知模型，具有不可替代的價值。更重要的是，古典瘟疫理論有助於打破傳染鏈交織迭加成群體流行的線性思維所帶來的道德難題，為促成全人類肩並肩面對風險、共同承擔責任與持續性協同抗疫的價值目標，提供一個基於中國文化傳統的論證依據。

In the study of concepts developed in the context of public health management in ancient China, the notion of infectiousness and plague theories in TCM (Traditional Chinese Medicine) are often perceived to have little significance to epidemic prevention and public health today because they are viewed as “unscientific.” This paper, however, argues that the doctrine of yinqi (the epidemic qi) and the concept of infectiousness in TCM present a dynamic interaction between diffuse environmental risks and human activities in a specific spatio-temporal context. The concept of epidemic qi offers a unique cognitive model with which to approach the epidemic risk in a given socio-historical environment that differs from a linear analysis of the “chain of infection” in modern medicine. The paper concludes that the plague theories reflected in TCM are relevant to the contemporary understanding of risk control during a public health crisis.
健康受試者的＂艱難抉擇＂
Authors: 王 嘉琪 , 鄧 蕊
Published: September 2023

LANGUAGE NOTE | Document text in Chinese; abstract also in English.

以新冠疫苗I期試驗的健康受試者為研究對象，基於深度訪談和虛擬民族志研究方法，採用NVivo11軟體進行編碼分析，發現健康受試者的參與動機多為積極動機，在抉擇過程中曾面臨內外矛盾而深陷糾結與掙扎。文章歸納出新冠疫苗受試者抉擇過程不同階段的動機與行為特點，即：萌生想法——躍躍欲試的受試者；進退狐疑——踽踽獨行的受試者；備受煎熬——忐忑不安的受試者；解惑釋疑——篤定前行的受試者。旨在真實地還原健康受試者的抉擇過程，消除社會偏見，為健康受試者和I期試驗去除污名，提升公眾的認知，增强健康受試者的認同感和歸屬感。

Taking the Phase I trial of the 2019-nCoV vaccine as a case study, this paper examines the motivational and psychological development and behavioral patterns of healthy volunteers who participate in different phases of clinical trials for vaccines. The findings of a series of in-depth interviews and virtual ethnographical studies show that participation in a clinical trial such as that for the 2019-nCoV vaccine is a difficult choice for volunteers, as it entails exposure not only to medical risks but also to social prejudice. The paper provides a detailed account of how the volunteers for the Phase I 2019-nCoV vaccine trials made their choice to participate and how they overcame various doubts and fears to serve as responsible research partners.
Studies of the Purolite CT151DRY alkylation catalyst by Purolite in the phenol alkylation reaction of ethylene oligomers of the C16-C18 fraction
Authors: Goryunova Alexandra Konstantinovna , Baklan Nina Sergeevna , Timofeeva Galina Vladimirovna , Nosova Elena Vladimirovna
Published: September 2023

The possibility of using a Purolite alkylation catalyst of the CT151DRY brand in the reaction of alkylation of phenol with ethylene oligomers of the C16-C18 fraction to obtain the target alkylphenol, which is a semi-product in the production of multifunctional additives to lubricants is considered in the article. It is shown that the Purolite CT151DRY catalyst is resistant to mechanical influences and high temperatures within the studied range up to 180 °C and the synthesis duration up to 50 hours while maintaining a high alkylating ability in the reaction of phenol alkylation by ethylene oligomers of the C16-C18 fraction and is highly sensitive to changes in the composition of raw materials and the change of raw ethylene oligomers. The Purolite CT151DRY catalyst has an alkylating ability comparable to other catalysts and can be recommended to obtain the target alkylphenol.
Probabilistic assessment of the effectiveness of the application of cyclic flooding of oil reservoirs method
Authors: Egorova Elena Valer'evna , Smolyanskaya Olesya Aleksandrovna , Pimenova Nadezhda Alekseevna , Smolyanskiy Aleksey Anatol'evich
Published: September 2023

Extraction of hard-to-recover hydrocarbons is becoming an urgent task for the entire world oil community. The development of new technologies and methods, as well as the improvement of existing ones, have become the main issue in the extraction of hydrocarbons at existing fields. The aim of the work was to develop the technology of hydrodynamic impact on the hydrocarbon deposit. The process of oil reservoirs flooding is one of the most widespread and traditional in the application of extraction of hard–to-recover oil. The most effective in terms of impact is the cyclic regime of flooding of oil reservoirs – periodic changes in fluid flow rates at injection and production wells with a phase shift of oscillations for individual groups of wells. The use of cyclic flooding in combination with an increase in the average level of injection pressures can give a significant increase in the coefficient of reservoir coverage in power. The degree of hydrodynamic connectivity of the layers along the section has a significant impact on the effectiveness of cyclic flooding. The coefficient of lithological connectivity of formations is determined by the ratio of the area of the reservoir confluence to the total area of the deposit and can characterize the hydrodynamic connectivity of formations along the section. Using the example of the D3 of the Korotkoye field, an assessment of the start-up of the wells of the PPD system was done as well as the analysis of the nature of its influence on the volume and water content of the extracted products of the D3 formation of the Korotkoye field under various injection modes using cyclic flooding. It is determined that when both injection wells are stopped for a long period, the output of the produced products decreases to 25%. The analysis of the total oil flow rate showed that in the variants with well shutdowns there is a stronger decrease in oil flow rate than in the variants with cyclic injection, in the variants with cyclic operation of the PPD system the highest indicators of accumulated oil production are achieved for a certain period.
The level of zooperiphyton development on artificial reefs established in the shallow zone of the northwestern part of the Caspian sea
Authors: Umerbaeva Roza Ivanovna , Kurapov Aleksey Aleksandrovich
Published: September 2023

The creation of artificial reefs is of great importance in increasing the production of marine biological resources and widespread distribution. Various goals are pursued under the implementation of such projects including the enrichment of local populations of fish and other marine life. Artificial reefs are usually rapidly populated by fouling, and research into these communities is of interest as they will increase food resources and shelters, making reefs more attractive to fish. This paper presents the taxonomic composition and quantitative characteristics of zooverifiton of artificial reefs installed at depths of 10-12 m in a remote part of the North Caspian. The results of the studies showed that on artificial reefs the level of development of organisms using them as a habitat is significantly higher than in the natural biotope. There was a seasonal decrease in the level of development of both individual species and, in general, zooverifiton by an average of 4 times. Compared to zoobenthos, the abundance and biomass of foulers were higher, this was most significantly observed in the summer. Quantitative indicators of zooverifiton formed crustaceans and molluscs in both seasons of research. The dominant periphyton species are mytilyaster and balyanus. The results of the studies showed that almost all species noted in fouling were found in the composition of zoobenthos samples taken near artificial reefs. Analysis of this study did not reveal an increase in species diversity in this area of the sea, however, a high level of abundance and biomass of organisms indicates the importance of artificial reefs to improve the food supply of fish.
Simulation And Optimization of Silicon Solar Cell Using MgF₂/SiO₂ Double - Layer Anti – Reflective Coating (ARC)
Authors: Mohmad Salleh Siti Hajar
Published: September 2023

The most common method of harnessing solar energy is photovoltaic. With the revolution of new energy innovation in recent years, generation of electricity based on photovoltaic has possessed great progress, however, high cost is one of the primary issues encountered. In order to drive into a better manufacturing technology, the effectiveness of the cells and modules is opt for further cost reduction. The purpose of this research is to study the parameter on crystalline silicon solar cell with double layer of MgF₂/SiO₂ as its anti-reflective coating (ARC) which is the thickness. An antireflection coating mostly introduced in solar cell in order to reduce the reflection of light from the front surface of the cell and to enhance broadband of light absorption. Four Light trapping (LT) scheme with double layer of MgF₂/SiO₂ and adjusted thickness on 100 µm thin crystalline silicon(c-Si) was investigated. The optical properties within 300-1200 nm wavelength region were analyzed and from absorption curve, maximum potential photocurrent density (Jmax) for each LT schemes was calculated. With the addition of ARC into the c-Si, the Jmax increased up to 32.13 mA/cm2 and achieved 28.89 % enhancement compared to the Jmax of the c-Si reference (without ARC). Therefore, it is important to achieve optimum value in absorption that literally showed the excellent optical property of MgF₂/SiO₂ bilayer coatings.
The effect of impregnation ratio on the yield of corn cob activated carbon by chemical activation
Authors: Bermakai Madhiyah Yahaya
Published: September 2023

Agricultural waste biomass as a precursor for the synthesis of activated carbons has increased in recent years. In spite of transportation cost, agricultural waste biomass is one of an environmentally friendly, readily available and known as renewable sources compared to conventional activated carbon which is very expensive and exhaustible. That is the main reason activated carbon derived from agricultural waste biomass has been widely used in a variety of applications in the environment and industry for the separation, retrieval, modification, and removal of diverse substances in the liquid and gas phases. The purpose of this research is to produce activated carbon (AC) from corncob through carbonization followed by chemical activation with sodium hydroxide. Initially, the corncob was ground and sieved into a powder form with a mesh size of 500 µm. Later, the powder was chemically activated with sodium hydroxide at different impregnation ratios (1:1, 1:2, and 1:4) under activation temperatures of 200 oC. The percentage of carbon yield and ash content were evaluated using a mathematical approach. The results revealed that the sample impregnated at ratio of NCAC 1:4 showed the lowest ash content (6.58 %) with highest carbon yield of 20.52 %. As the impregnation ratios of sodium hydroxide increases, these entrapped chemicals in the activated corncob contributed in high carbon yield and reduced ash content.
Physicochemical and adsorption properties of guava leaves-activated carbon by hydrochloric acid on adsorption of methylene blue
Authors: Abdullah Mohd Fauzi
Published: September 2023

This study emphasizes the biomass waste which is dried guava leaves as a natural low-cost adsorbent precursor of activated carbon for methylene blue (MB) dye solution due to its high abundance and availability in Malaysia. MB dyes which were largely consumed by the textiles industry pose several hazardous complications on human health without proper wastewater treatment. Thus, adsorption for water treatment serves as a cost-effective method to adsorb the dyes using low-cost adsorbent from dried leaves biomass. The dried leaves underwent chemical activation with hydrochloric acid (HCl) with ratio 1:1 and were carbonized at 700 °C for an hour and then neutralized for characterization and batch adsorption study. The physicochemical properties of guava leaves HCl activated carbon (GL-HAC), was characterized using ash content, moisture content, bulk density and iodine number. Percentage yield of GL-HAC was apparently high at 89.90 %. The GL-HAC reported had relatively low percentage of ash content and moisture content. The bulk density of the activated carbon was also low at 1.6 g/mL. The iodine number was calculated at 339.9 mg/g. The pHPZC for GL-HAC was obtained at 4.3 indicating that this activated carbon is efficient for the removal of MB dye with the pH solution above the pHPZC value. The results of the FTIR study shows that the functional groups of hydroxyl, amine, carbonyl, and carboxylic acid are present in GL-HAC. Batch adsorption studies were carried out to determine the most favourable condition for the activated carbon to adsorb methylene blue dye. The operating variables studied were adsorbent dosage, initial pH of solution, initial dye concentration and contact time. The results revealed that the effect of initial concentration and contact time were directly proportional to the adsorption capacity of MB dyes on the activated carbon. Thus, this study has demonstrated the potential of dried guava leaves as low-cost precursor of activated carbon for the removal of MB dyes.
Effect of Chemical Treatment on Physical and Mechanical Properties of Coir Fibre-Polypropylene Composites
Authors: Gisip Judith
Published: September 2023

Research on natural fibres as reinforcement in polymer composite has increased in the past few years. Due to environmental concerns, researchers are substituting synthetic fibres with natural fibres as the main component in composites. Natural fibres have acceptable mechanical properties, material renewability, cost-effective, biodegradable and eco-friendly. This study aimed to determine the effect of chemical treatment on physical and mechanical properties of composites made from coir fibre bonded with polypropylene. Coir fibres were used as reinforcements while polypropylene was used as the matrix. Coir fibre-polypropylene composites were produced with different mixing ratios of 0:100, 10:90 and 30:70. The coir fibres were screened at 30 mesh and treated separately with alkaline and alkaline-silane. The effect of chemical treatment on water absorption, thickness swelling, bending and tensile were determined in accordance with ASTM standards (ASTM D570, ASTM D790 and ASTM D3039). Results revealed that coir fibres treated with alkaline-silane resulted in superior performance in physical and mechanical properties compared to untreated coir fibres and those that were treated with alkaline. The alkaline-silane treatment resulted in a reduced number of hydroxyl groups, thus, increasing the physical properties of the composites. Additionally, the treatment also increased the mechanical properties by improving the level of adhesion between the fibre and matrix. In conclusion, chemical treatment improves the strength and properties of coir fibre-polypropylene composites and can be used as a potential product for various industries.