bluuebunny/crossref_metadata_2025 huggingface dataset:
METODO SENCILLO PARA CONSIDERAR LA IRREGULARIDAD DE ESTRUCTURAS EN EL DISEÑO SISMORRESISTENTE. APLICACIÓN EN LA DETERMINACION DE ACELERACIONES DE PISO PARA EL DISEÑO SÍSMICO DE DIAFRAGMAS, APENDICES, Y ELEMENTOS NO ESTRUCTURALES EN EDIFICIOS
Authors: Restrepo José I. , Rodriguez Mario E. , Núñez Juan , Reinoso Eduardo
Published: January 2025

Para fines de diseño, la NTC Sismo 2017 y la propuesta de la NTC Sismo 2023 tienen procedimientos para considerar las condiciones de regularidad tanto en planta, como en elevación, de las estructuras. Algunas de estos procedimientos intervienen para determinar las aceleraciones de piso, con soluciones que no son amigables. Para el diseño sísmico de diafragmas, apéndices y elementos no estructurales en edificios, es necesario conocer las aceleraciones de piso, con las cuales es posible definir las fuerzas sísmicas de diseño en estos elementos. Para estructuras que no son regulares, la NTCS 2017, especifican procedimientos de cómputo de aceleraciones de piso muy diferentes a los especificados para estructuras regulares, y diferentes también a los procedimientos de la ASCE 7-16 y 22. Edificios con distribuciones irregulares de rigidez o masa pueden tener demandas de aceleraciones de piso más grandes que las correspondientes a edificios regulares.
Para los casos de edificios que no tienen configuraciones estructurales regulares, este trabajo propone un método sencillo de penalización de las aceleraciones de piso especificadas para estructuras regulares por la NTCS 2017. Este método se basa en resultados del estudio de propiedades dinámicas de 23 edificios de concreto reforzado, de marcos, o duales, con un número de niveles que varían de 4 a 30, con diferentes niveles de irregularidad. Estos edificios fueron diseñados por empresas consultoras de México, y las propiedades dinámicas fueron obtenidas del análisis de estos edificios, llevados a cabo por estas empresas. Se dan ejemplos sencillos de aplicación del empleo del método de penalización propuesto para casos de edificios que no son regulares. Los resultados de estos ejemplos sugieren la conveniencia del empleo del método, por su sencillez, por la congruencia de los resultados de su aplicación con la respuesta esperada de la estructura, y porque la relación de masas que emplea el método es una medida eficaz para identificar el nivel de irregularidad de una estructura.
Perdidos en América: La exploración humana en John Cassavetes y Jim Jarmusch
Authors: Castro Javier , Franco Meza Gian , Simón Kevin
Published: January 2025

Tras los pasos vanguardistas dados por la nouvelle vague a finales de la década de 1950 e inicios de la década de 1960, el actor reconvertido en director John Cassavetes construyó un pequeño sistema anti Hollywood que, libre de ataduras y estructuras establecidas, generó un shock en los jóvenes cineastas del país de las oportunidades. Tras el pistoletazo de salida del nuevo cine independiente liderado por Cassavetes, 25 años después una figura cinéfila rompió los moldes de representación con un retrato siempre curioso e inteligente, un forastero permanente: Jim Jarmusch. Esto abre la interrogante: ¿hay influencia de Cassavetes en el cine de Jarmusch como figuras representativas del cine independiente?
Lucio Fulci (1927-1966)
Authors: Pita César , Martínez Juan Carlos
Published: January 2025

Lucio Fulci siempre defendió la idea de que el cine era mentira. Por lo tanto, la violencia que él representa en pantalla no es más que un ejercicio de ficción en el que la exageración es válida como forma de expresión. Controversial en su momento, el director italiano ha recibido el calificativo de misógino, enfermo y depravado, autor de un cine perverso y falto de cualidades artísticas. Aunque es más conocido por su rol clave en el cine de terror extremo, su obra explora también la comedia picaresca, el spaghetti western y el musicarello, así como algunas cumbres del giallo.
O ZNAČAJU HAJDEGEROVOG UČENJA ZA ESTETIKU I FILOZOFIJU UMETNOSTI (I DEO) ŠELING, HEGEL I HAJDEGER
Authors: RAJKOVIĆ MARICA
Published: January 2025

Autor ispituje značaj ključnih Hajdegerovih teza o umetnosti i uticaj koji one imaju na estetiku, filozofiju umetnosti i njihov razvoj. Ispituje se stvarni doprinos i originalnost Hajdegerovih teza na osnovu kojih se on smatra epohalno važnim i nezaobilaznim autorom kada je u pitanju korpus estetičkih i poietičkih filozofskih disciplina. Teza o umetnosti kao izvornoj formi mišljenja je Šelingova teza. Teza o umetnosti kao otkrivanju istine je teza koju je pre Hajdegera postavio i sistematizovao Hegel. Za razliku od isticanja pomenutih stavova, autor smatra da stvarni Hajdegerov doprinos i značaj za filozofiju umetnosti treba tražiti u ideji prema kojoj je umetnost ta koja „prirodno pušta“, dok je tehnika ona koja „veštački izaziva“. Problem sa tom idejom, međutim, odnosi se na činjenicu da Hajdeger ne pokazuje dovoljno smelosti da tezu o poietičkom kao prirodnom formuliše sâm, nego je učitava u antičku filozofiju. Antički Grci, međutim, ποίησις nisu razumeli kao φύσις, što znači da je na delu Hajdegerovo naknadno menjanje smisla starogrčkih pojmova i izazivanje tih pojmova da označe nešto što u svoje vreme zapravo nisu označavali. Tim izazivanjem i učitavanjem novog smisla, Hajdeger se, ako se dosledno razume njegova vlastita misao, prema starogrčkim pojmovima odnosi tehnički, odnosno – metafizički.
MIŠEL ANRI O APSTRAKTNOM SLIKARSTVU: KANDINSKI I SLIKANJE NEVIDLJIVOG
Authors: POPOVIĆ UNA
Published: January 2025

Ovaj rad posvećen je fenomenološkoj estetici Mišela Anrija, odnosno njegovom tumačenju apstraktnog slikarstva. Anrijev fokus je stvaralaštvo V. Kandinskog, za koje francuski fenomenolog smatra da je odlikovani slučaj apstraktnog slikarstva koje pokazuje da su sve umetnosti suštinski apstraktnog karaktera. Analiza će sučeliti stavove Kandinskog sa stavovima Anrija, a biće posebno fokusirana na pojmove unutrašnjeg i spoljašnjeg, na pitanje odnosa sadržaja i sredstava slikanja, te na problem boja i čulno opažljivih kvaliteta. Rezultat analize pokazaće okvire susreta i domete fenomenološkog tumačenja slikarstva Kandinskog.
HAJDEGEROVI POJMOVI SVETA I ZEMLJE. PROBLEM ISKUSTVA UMETNIČKOG DELA
Authors: MILADINOV MILOŠ
Published: January 2025

Autor u radu ispituje mogućnost pristupa Hajdegerovim pojmovima sveta i zemlje kao kategorijama za recepciju umetničkog dela. Nasuprot na prvi pogled samorazumljivom pristupu Hajdegerovom shvatanju umetnosti kao Werkästhetik projektu, u radu se zastupa stanovište koje tvrdi da je u Hajdegerovom fokusu pre svega iskustvo umetničkog dela, a tek u sekundarnom smislu i suština samog dela. Ta teza se zastupa putem interpretacije Hajdegerovih pojmova sveta i zemlje kao pojmova koji izrastaju na osnovu iskustva umetničkog dela, čime se želi ukazati da oni u primarnom smislu markiraju upravo samo to iskustvo. Ovakav pristup pojmovima sveta i zemlje, kako u zaključku rada naglašavamo, omogućava da se ovi pojmovi primene i na iskustvo savremenih umetničkih praksi, što ne bi bilo moguće u slučaju da su pojmovi sveta i zemlje mišljeni isključivo kao kategorije za umetničko delo.
ISTORIJA RECEPCIJE MARKSOVOG MIŠLJENJA (II DEO)
Authors: PEROVIĆ MILOŠ
Published: January 2025

U radu kojim se nastavlja obeležavanje sto pedesete godišnjice od objavljivanja prve sveske Marksovog Kapitala, autor se bavi najbitnijim momentima recepcije ovog dela. Autor obuhvata period od 150 godina u kom se osvrće na interpretaciju Kapitala u okviru tzv. marksizma, najbitnije momente kritike ovog dela, ali i istorijat ove knjige i marksističke misli na području bivše Jugoslavije. Centralno mesto rada je recepcija i interpretacija Marksove teorije vrednosti i dijalektičkog metoda. U ovom delu rada zastupljena je moderna marksistička recepcija Marksove misli od šezdesetih godina 20. veka do danas, ali i istorijat marksističke recepcije Marksove misli na jugoslovenskom govornom području, kao i osvrt na najbitnije momente kritike Marksove kritike političke ekonomije u ekonomiji i društvenim naukama.
РЕЦЕПЦИЈА ДРАМЕ НАХОД СИМЕОН (1938) ТОДОРА МАНОЈЛОВИЋА: КАКО ЈЕ ПРЕДЛОЖАК ПОЈЕО ТЕКСТ?
Authors: Поповић Емилија А.
Published: January 2025

У раду се анализирају секундарни извори литературе о драми Тодора Манојловића Наход Симеон из 1938. године. Рад ће бити посвећен студијама, чланцима и есејима који отварају пут за даљу анализу поетике драмског текста овог писца. Такође, у раду ће се критички анализирати и вредновати оне студије које су писане у компаративном кључу (Мустеданагић 2004; Радоњић 2007). Драма се у њима сагледава у односу на традицију драма са мотивом находа у српској књижевности. Предмет рада представљају и аналитичко-интерпретативни текстови, као и текстови са биографским приступом (Тополовачки 1978; Хајдуковић 2000). Прегледни рад Марте Фрајнд о позоришној заоставштини Тодора Манојловића (1997), посматраћемо заједно са есејем насталом на његовим темељима – „Драмски кругови Тодора Манојловића“, из 2019. године, а анализираћемо и рад Бојане Поповић који је објављен у оквиру књиге Тодор Манојловић и позориште (Поповић 2020). Осим тога, биће речи и o есеју „Наход Симеун – драма човечанства“ Милоша Радојичића (1939), који представља једно од оригиналнијих тумачења наше народне легенде, те студији новијег датума која је умногоме базирана на истраживањима Ота Ранка, Клода Леви-Строса и Олге Фрајденберг „Mitologica heroicа (I) – граматика мита о Находу Симеону“ Ђорђа Кебаре (2019).
KONTRASTIVE ANALYSE DER PHRASEOLOGISMEN MIT DEM LEXEM VOGEL IN DER DEUTSCHEN UND SERBISCHEN SPRACHE
Authors: Kobetits Dénes H.
Published: January 2025

Das Thema der vorliegenden Arbeit stellt die kontrastive Analyse der Phraseologismen mit dem Lexem Vogel (‚ptica‘) in der deutschen und serbischen Sprache dar. Ziel der Arbeit ist, durch diesen Vergleich zu erforschen, inwieweit serbische Äquivalente für die untersuchten deutschen Phraseologismen vorhanden sind, sowie zu ermitteln, welcher Grad der Äquivalenz zwischen diesen Phraseologismen besteht. Das der Untersuchung zugrundeliegende Äquivalenzmodell zur Bestimmung des Äquivalenzgrades ist jenes von Harald Burger. In der Arbeit wird zunächst im Rahmen eines einleitenden theoretischen Teils ein Überblick der Disziplin der Phraseologie und ihrer für die Untersuchung relevanten Grundbegriffe gegeben. Im praktischen Teil folgt der kontrastive Vergleich der serbisch- und deutschsprachigen Phraseologismen mit der Komponente Vogel. Als Ausgangssprache der kontrastiven Analyse dient die deutsche Sprache, während die serbische Sprache die Rolle der Zielsprache innehat. Als Ergebnis dieser Untersuchung lässt sich festhalten, dass im Falle der Phraseologismen mit der Komponente Vogel nur äußerst wenige volläquivalente Wendungen in der serbischen Sprache identifiziert werden konnten. Nichtsdestotrotz konnte zumindest auf semantischer Ebene eine Äquivalenz bei einem gewissen Anteil der untersuchten Phraseologismen ausfindig gemacht werden.
ЖИВОТ НИ ПАОРСКИ НИ ГОСПОДСКИ
Authors: Којић Тања П.
Published: January 2025

Рад се бави новелом „Булка“ Вељка Петровића. Кратка прича је подешена теми земље, познатој преокупацији овог приповједача војвођанске равнице. Судбину сеоске дјевојке Петровић је приказао у аналогији са пољском биљком булком, коју нико не воли и свако може да је повриједи и уништи. Петровићева антејска поетика огледа се у причи о дјевојци између тежачке и господске средине на непрегледној бачкој равници, која у себи носи обрисе митске приче о страдању и изгнанству. Базирана на сукобу личности и средине, Петровићева новела заузима врх његовог приповједног стваралаштва. У овом раду сагледаћемо новелу из више аспеката и указати на њен митски контекст, везу са ритуалом и обредом, говорићемо о мотиву фине и њежне љепоте као страшног недостатка у атмосфери салашарско-варошког живота, као и мотивима малог раста и љубоморе у непросвећеној средини.
О ЕУФЕМИЗМИМА У РУСКОЈ И СРПСКОЈ ШТАМПИ
Authors: Козомора Наташа Н.
Published: January 2025

Овај рад се бави еуфемизмима у руском и српском језику. На изабраној грађи из руске и српске електронске штампе у раду се утврђују њихове формално-језичкe и лексичко-семантичкe особине. Примењује се контрастивни метод у циљу утврђивања сличности и разлика у поступку еуфемизације у двама језицима. Теоријски оквир представљају истраживања о еуфемизмима Е. П. Сеничкине, као и В. П. Москвина, Д. Н. Шмељова, Л. П. Крисина и др.
L'environnement socio-économique du Projet FED : Forêt domaniale de Rugazi
Authors: Mauranges Patrice
Published: January 2025

Le projet de reboisement de Rugazi a été bien accueilli par la population locale, parce qu'elle y a été directement associée et qu'elle a pu se rendre compte des avantages qu'elle pouvait en tirer.Bien que l'objectif forestier ait été prioritaire tout au long du projet, la création d'une bergerie, l'aide au regroupement en petits villages, les premiers systèmes d'adduction d'eau, la mise à disposition d'étangs et leur empoissonnement, ont contribué à la réussite du projet. Bien entendu, ce succès est indissociable de la création d'emplois liés aux travaux forestiers et, par la suite, pour l'exploitation du bois récolté.Au niveau régional, la construction d'un réseau dense de routes a permis à cette partie du Burundi de ne plus être coupée du reste du pays.Et au niveau national, ce projet - le premier parmi d'autres prévus - représente un pas important dans la réalisation des objectifs fixés par les autorités burundaises.
Talking it out? Metacognition, teacher talk, and comprehension consequences
Authors: Baumann Jennie
Published: January 2025

This study examines how the amount of teacher talk supports elementary-aged readers’ use of metacognitive strategies to comprehend text. One fourth-grade teacher’s small group reading sessions (n=5 sessions; 2 with advanced readers, 3 with striving readers) were observed and analyzed for metacognitive reading strategy implementation, some with a think-aloud protocol and some with curriculum materials. Results indicate that more teacher talk during small group lessons led to fewer metacognitive behaviors from striving readers. Small-group lesson talk focused on lower-level questions and problem-solving/support strategies initiated and scaffolded by the teacher, resulting in minimal opportunities for students to independently engage with text.
“It Makes Me Feel Like a Real Author”
Authors: Moylan Michael
Published: January 2025

This study explored multimodal literacies as it pertained to the use of digital technologies to create multimodal, digital texts within the scope of writer’s workshop in a fifth-grade classroom. The research was conducted from the viewpoint of sociocultural theory, multiliteracies, and New Literacies as writing is a social practice and communication is multimodal. Analysis of six classroom observations, student interviews, a student focus group, and a teacher interview indicate using multimodal literacies: (a) fosters high levels of engagement, (b) enhances meaning-making, (c) fosters opportunities for collaboration, (d) provides opportunities for publishing of professional-looking books for an authentic audience, and (e) fosters writing skills and writer identity.
Réflexion autour des pratiques de littératie familiales d’élèves inscrits au programme d’actualisation linguistique en français au sein d’écoles élémentaires de l’Ontario
Authors: Bangou Francis , Fleuret Carole
Published: January 2025

Cet article présente les résultats d’une étude qui avait pour objectif de décrire les pratiques langagières et de littératie familiale de parents d’élèves inscrits au programme d’actualisation linguistique en français au sein d’écoles élémentaires de langue française de l’Ontario. Nous avons reçu les données de 38 familles à l’aide d’un questionnaire qui a été distribué aux parents d’élèves inscrits à ce programme dans trois conseils scolaires francophones des régions d’Ottawa et de Toronto. L’essentiel des pratiques déclarées de littératie familiale était conforme à ce que préconise la recherche dans le domaine. Des pistes de réflexion et d’intervention seront amorcées concernant l’implication des familles dans le développement des pratiques de littératie des élèves inscrits au programme retenu.
Building a Pedagogy of Writing Transfer Through an Undergraduate Journal Publication
Authors: Harris Kaitlyn , France Paige , Eaton Christopher
Published: January 2025

Despite effective knowledge transfer being a primary goal among post-secondary instructors, scholars, and administrators, students still have difficulty adapting their skills to novel contexts. This challenge is especially salient in writing pedagogy, where the transfer of writing-related knowledge is not guaranteed (Driscoll, 2011; Perkins & Salomon, 2012). To investigate possibilities for catalyzing writing transfer, this paper reports on a collaborative autoethnography project (Chang et al., 2013) carried out by two undergraduate students and a faculty member based at a large Ontario university. Their experiences on the editorial team of a first-year writing journal provide insight into how mentorship within journal environments can contribute to post-secondary students’ literacy development, and, concurrently, help them to transfer what they know to new contexts. We consider how similar learning opportunities may contribute to undergraduate skill development outside traditional classroom contexts.
Exploring the Orton-Gillingham Approach to Teaching Reading from the Perspective of Tutors at the Scottish Rite Learning Centre for Children - Halifax
Authors: Hollis Heather , Harkins Mary Jane
Published: January 2025

Research indicates that individuals with poor reading skills are more at risk of dropping out of school and having fewer career options than their peers who are proficient readers (Castles at al., 2018; Jamieson, 2009). The Scottish Rite Learning Centre for Children - Halifax (SRLCC-H) in Nova Scotia offers tuition-free tutoring services based on the Orton-Gillingham approach, to students with reading-based learning disabilities, such as dyslexia. Through individual interviews, this study explores the perspectives and experiences of the volunteer tutors and tutors-in-training at the SRLCC-H. The findings indicate that OG tutoring improved their students’ reading abilities and increased their levels of confidence.
High School English Language Learners’ Experiences and Perceptions of Independent Online Content-Based Instruction
Authors: Lee Kent , Abbott Marilyn
Published: January 2025

Although technology-enhanced learning has exploded, limited research has examined English language learners’ (ELLs) experiences and perceptions of independent online content-based second language learning. To fill this gap, an innovative web application was designed to improve ELLs’ grade 10 science content and English language learning. Fifty-six high school ELLs independently completed 30 online modules and then responded to a 12-item questionnaire about the web application, the module content, and their learning. An applied thematic analysis of their responses revealed several benefits and a few challenges that provide insights for the development and improvement of independent online content-based learning for high school ELLs.
Análise da tradução das partículas modais alemãs na série How to sell drugs online
Authors: Aquino Marceli
Published: January 2025

Este trabalho apresenta uma análise da ocorrência das partículas modais (PMs) alemãs e sua Tradução Audiovisual na série How to sell drugs online (fast) da Netflix. Através das legendas e dublagens, realizamos um levantamento das decisões tradutórias das PMs para o português brasileiro. A interpretação de elementos linguísticos altamente sensíveis ao contexto e sem equivalentes diretos em outras línguas, como é o caso das PMs, apresenta um grande desafio para a tradução (Schoonjans, 2015). Não obstante, pesquisas recentes apontam a existência de meios modais em outros idiomas, que podem ser relevantes para a tradução, assim como para se obter uma compreensão mais ampla de aspectos modais em diversos idiomas (Waltereit, 2001). Em português, mesmo sem uma classificação homogênea, encontra-se cada vez mais o uso de palavras modais (como mas, aí e é que) que, dependendo do contexto, podem expressar funções comunicativas semelhantes às PMs alemãs. A análise da amostra da série indicou que, das 642 PMs alemãs presentes, a dublagem apresenta o maior número de soluções tradutórias (276), das quais 44% empregaram palavras modais no português. Estes resultados demonstram a pertinência de investigações sobre as PMs brasileiras para a sua tradução no par alemão/português.
Espiritualidade e ciências sociais
Authors: Toniol Rodrigo
Published: January 2025

O que a noção de espiritualidade opera quando é empregada como uma categoria analítica? O que esse termo descreve? E qual enquadramento induz cada vez que é mobilizado? A amplitude dessas perguntas dimensiona os desafios que essa noção impõe e a urgência da tarefa de tornar mais consciente seu uso nas ciências sociais. Afinal, apesar da longa trajetória histórica dos debates acerca da categoria espiritualidade na filosofia clássica e na teologia, no campo da antropologia a análise pormenorizada dos usos e das apropriações da “espiritualidade” é um tema pouco frequente e sistematizado. Este artigo consiste em uma reflexão teórica sobre a noção de espiritualidade nas ciências sociais.
LA PRODUCCIÓN CIENTÍFICA SOBRE LA ADMINISTRACIÓN PÚBLICA EN AMÉRICA LATINA. UN ESTUDIO BIBLIOMÉTRICO 2012-2022
Authors: Ramírez Brouchoud María Fernanda , Franco Vargas María Helena , Vega Giraldo Alejandro , Cataño-Buritica Joshua
Published: January 2025

Este artículo analiza la producción científica sobre la administración pública en América Latina. Se realizó la búsqueda en tres bases de datos: Scopus, Web of Science y Dimensions, teniendo en cuenta únicamente el periodo comprendido entre los años 2012 y 2022. Se utilizó una bibliometría de tipo exploratorio descriptivo con el objetivo de identificar las principales innovaciones teóricas, debates y tendencias en torno a la materia. El proceso de recopilación de la información fue apoyado por el Centro Cultural Biblioteca Luis Echavarría Villegas de la Universidad EAFIT y se desarrolló en tres etapas: definición de parámetros y criterios de búsqueda, selección de las bases de datos y sistematización de la información. La categoría más estudiada en los documentos es la de gobierno en línea, además, se evidencia un aumento en la cantidad de documentos producidos durante la pandemia por COVID-19. Los autores más productivos están asociados a instituciones de España y las revistas con mayor producción pertenecen a centros académicos de España, Brasil y Venezuela. Además, se encontró que el idioma de publicación predominante es el inglés y que los asuntos de género tienen poca presencia en la literatura actual.
Iliopsoas Injections
Authors: Katz Luca , Feinberg Griffin , Kent Victoria , Quinn Matthew , Milner John D. , Tabaddor Ramin
Published: January 2025

Background:

Iliopsoas injuries are a common cause of anterior hip and groin pain and can be successfully managed with conservative treatment. Corticosteroid and local anesthetic injections can also be offered in conjunction with nonoperative management. Given the variability in reported injection guidelines, composition, and techniques, the purpose of this study was to systematically review the literature to assess progression to surgery and patient outcomes following iliopsoas injections.

Methods:

Four online databases (PubMed, Cochrane Library, MEDLINE, and Scopus) were searched for studies investigating the outcomes of iliopsoas injections from database inception until January 2024 in accordance with the Preferred Reporting Items for Systematic Meta-Analyses guidelines. Three reviewers screened titles, abstracts, and full-text articles independently and in duplicate. Recorded data included demographic data, patient-reported outcomes, complications, injection traits, and progression to surgery.

Results:

Six articles were included in the review (follow-up time = 28.6 months). These studies included patients with iliopsoas bursitis, tendinopathy, and snapping hip. Five studies used the iliopsoas bursa as the injection target. All studies used local anesthetics in their injection formulations, with 5 also adding a corticosteroid. In 3 studies, the Numeric Rating Scale improved from preinjection (mean = 7.33) to postinjection (mean = 2.47). Three studies demonstrated an improvement in Harris Hip Score from a mean of 58.49 preinjection to 89.91 postinjection. Following injections, 28.9% (68/235) of patients progressed to surgery, with psoas tenotomy (38.3%, 26/68) being the most common procedure. There were no complications reported in all of the included studies.

Conclusion:

This study demonstrates that iliopsoas injections are a clinically effective treatment of a variety of pathologies, including bursitis, tendinopathy, and snapping hip, and have a low rate of complications. Physicians should consider using iliopsoas injections in patients whose symptoms are refractory to conservative management, including physical therapy.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
Itierella melognensis n.gen., n.sp., and Paradicostella hautevillelompnesensis n.gen., n.sp. (Ammonoidea, Neocomitidae, Neocomitinae), two new upper Valanginian trituberculated ammonoids from the Jura Mountains, eastern France
Authors: Pictet Antoine , Hugon Bruno , Pierangelini Gustavo
Published: January 2025

Several ammonoid specimens from the upper Valanginian (Lower Cretaceous) sedimentary succession of Hauteville-Lompnes, Department of Ain, eastern France, are assigned to the new genera and species Itierella melognensis n.gen., n.sp., and Paradicostella hautevillelompnesensis n.gen., n.sp. Specimens collected in the past were misidentified as Acanthodiscus Uhlig, 1905, and erroneously assigned to the lowermost part of the Hauterivian stage. The revision of the Marnes de Mélogne, along with the collection of a rich associated ammonite fauna, allows Itierella to be recognized as a latest Valanginian homeomorphic form of the genus Acanthodiscus, and Paradicostella as closely related to the genus Dicostella Busnardo, 1966. The Marnes de Mélogne are revised as mostly belonging to the upper Saynoceras verrucosum to Criosarasinella furcillata ammonite zones (uppermost Valanginian), while their uppermost metre is assigned to the Acanthodiscus radiatus Zone (lowermost Hauterivian).
Porosity and mineralogy in the Lajas tight gas sandstone reservoir, Neuquén Basin, Argentina
Authors: Lavauzelle Nathan , Siitari-Kauppi Marja , Sardini Paul , Loggia Didier , Sammaljärvi Juuso , Beaufort Daniel , Rainoldi Ana Laura , Minisini Daniel
Published: January 2025

In specific subsurface conditions, the sandstones of the Lajas Formation represent a tight gas reservoir in a deltaic mouth-bar system. Therefore, understanding the diagenetic processes that affected these sandstones is a first step towards reservoir quality prediction and production optimization.14C-PMMA autoradiography can be used to characterize the porosity distribution at centimeter-to-micrometer scales. The mineral phases can be associated with specific porosities using scanning electron microscopy (SEM) in the backscattered-electron imaging mode (BSEi) and can be combined with elemental mapping using energy-dispersive X-ray spectroscopic (EDS) analysis. For bulk analysis, porosity mapping is useful for characterizing the constrictivity and the tortuosity of the porous network created by the geological processes related to the basin’s evolution (e.g., compaction, dissolution, fracturing, cataclasis). 14C-PMMA autoradiography offers a reliable porosimetry method which is adaptable to most rocks. In our study, the superimposition of porosity maps and mineral maps revealed that: 1) secondary porosity, deriving from feldspar dissolution in medium- to coarse-grained sandstone, and the varying degree of dissolution are both influenced by grain size and degree of cementation, 2) mudstone rip-up clasts have homogeneous porosities (3–4%), 3) the host rock’s porosity varies widely (1–8%), 4) bioturbated siltstone and sandstone present higher porosities within the trace fossils, mainly associated with organo-pores (primary porosity in the organic matter), mineral formation (pyrite precipitation), and clay development (microporosity). Integrating these petrophysical and mineralogical observations with the interpretation of the sedimentary and structural processes that affected the lithologies analyzed allows the following generalizations: 1) the highest porosity and permeability occur in samples representing high-energy environments of deposition (deltaic channel infills and mouth bars), 2) deformation bands cannot be considered fairways for fluid migration, as they have a lower porosity than the sandstone matrix, mainly because dilational shear bands underwent cementation and compactional shear bands underwent cataclasis.
Identification of Reservoir Heterogeneities Using Tracer Breakthrough Profiles and Genetic Algorithms
Authors: Guerreiro J.N.C. , Barbosa H.J.C. , Garcia E.L.M. , Loula A.F.D. , Malta S.M.C.
Published: January 2025

In this paper we describe a methodology to identify reservoir properties using numerical techniques which combine finite element methods, a streamline approach and genetic algorithms. As a model problem we consider the system of equations governing incompressible miscible displacement in two-dimensions whose solution furnishes tracer breakthrough profiles which are parametrized as function of the properties to be determined. Given a "population" of initial parameters, after the solution of the model problem and the comparison of each profile with a target one, we "evolve" to a new "population" following the concepts of genetic algorithms and according to the fitness of each member of the previous "population".
Characterization of Corrosion Inhibiting Emulsions for Continuous Well Treatment
Authors: Civan Faruk , Martin Richard L. , Weers Jerry J.
Published: January 2025

Field experience has proven that water or oil-external emulsions containing properly formulated corrosion and scale inhibitors and cleaners, placed downhole in sufficient quantities, can provide more effective and long term well treatment than the frequently used oil-based products. The gradual break-up of emulsions due to the downhole shearing and heating conditions of wells yields a means of controlled release of the active ingredients present in these emulsions over a long period of time.

The typical properties of corrosion inhibiting emulsions affecting the downhole placement of emulsions are measured and correlated by relevant theories. The mechanisms of the emulsion break-up and inhibitor release by various effects including shearing and heating are determined, formulated, and verified by experimental data~ The viscosity, drying and stability processes, surface tension and repetitive film coating on tubing and casing walls, inhibitor resolution and return profiles of the typical water and oil-external emulsions used in industry are correlated. A transient-state model for emulsion break-up and consumption, temperature, and the remaining and delivered inhibitor concentrations of downhole emulsion reservoirs is developed and verified by experimental data. This model is used to simulate typical scenarios and determine the sensitivity of the various parameters involved in well treatment.
Prevalence and associated factors of Needle Stick and sharp Injuries Among health care workers ın a teiıtiary care hospıtal Mogadishu, Somalia
Authors: isse Suad abdikarim , DOĞAN Ahmet , Çelik Ali kutta , Ali Tigad Abdisad , Wehlie Jabir Abdullahi , Sheikh Sowda Abdikarim , Ali Ahmed Mohamed , Hussein Lıban Ade , Adam Fatima Nor , TÜRKAN Mucahit
Published: January 2025

Background
Needle sticking and sharps injuries (NSSIs) are significant occupational hazards for healthcare workers (HCWs), contributing to the transmission of blood-borne pathogens such as hepatitis B, hepatitis C, and HIV. However, the prevalence and associated risk factors for NSSIs, particularly in low-resource settings, remain underexplored.
Materials and Methods
A cross-sectional survey was conducted with 334 healthcare workers in a tertiary care hospital in Mogadishu, Somalia, in which questionnaires were used to assess injury occurrence, demographic data, and safety practices.
Results
The majority (72.4%) were aged between 26 and 40 years, with males accounting for 55.6% of the study population. A significant proportion (59.5%) reported being single. Nurses and midwives constituted the largest professional category, representing 33.6% of the participants. Notably, 72.7% of the respondents reported working night shifts. With respect to educational qualifications, 64.6% held a bachelor’s degree, and 50% had between 6 and 10 years of professional experience.
Conclusion
This study highlights the alarming prevalence of NSSIs among healthcare workers in Somalia, emphasizing the occupational risks faced by nurses, followed by doctors. These findings underscore the urgent need for enhanced safety protocols, training, and awareness campaigns to mitigate these injuries and protect healthcare workers from blood-borne infections.
High host specificity of alphacoronaviruses in Nearctic, insectivorous bats
Authors: Kotwa Jonathon , Bhuinya Arkadeb , Yim Winfield , Gallo Giulia , Singh Pahul , Liu Qiang , Kumar Anil , Chien Emily , Hou Aaron , Chee Hsien-Yao , Blais-Savoie Juliette , Yip Lily , Von Zuben Valerie , Wouters K. Aidan , Misra Vikram , Lung Oliver , Bailey Dalan , Maguire Finlay , Banerjee Arinjay , Mubareka Samira , Davy Christina
Published: January 2025

Bats are reservoir hosts for a number of coronaviruses, some of which may pose spillover risks for humans and other animals. Surveillance for bat coronaviruses in temperate regions remains limited and represents an important blind spot for emerging pathogen preparedness and bat conservation. We detected two alphacoronaviruses in big brown bats (Eptesicus fuscus) and little brown myotis (Myotis lucifugus) in the province of Ontario, Canada. These viruses are closely related to other coronaviruses circulating in bats in North America and Asia and also related to human and swine coronaviruses. We found unexpected diversity in the spike gene of these highly similar coronaviruses. High homology in the receptor-binding domain (RBD) was maintained in viruses derived from the same species of bat, but markedly lower in those derived from other species. RBD in silico structural analysis of closely related coronaviruses suggests that the viruses we detected are less likely to use bat APN (30 bat species) or ACE2 (20 bat species), or human DPP4 or TMPRSS2 as putative receptors or attachment factors. To gain early insights into interferon antagonism, we also functionally characterized the accessory protein ORF3 from both bat viruses and discovered that ORF3 inhibited both IFNβ production and signaling. Taken together, our study provides insights into coronavirus diversity in Nearctic, insectivorous bats in a previously under-sampled region. This work provides a baseline for more in-depth surveillance to better characterize the transmission dynamics of endemic coronaviruses in free-ranging wildlife, and for exploring the evolutionary relationships between coronaviruses and their hosts.
Assessment of multi-strain probiotic exhibiting in vitro cholesterol-lowering, antioxidative and lipolytic properties
Authors: Chauhan Mehul , Modasiya Ishita , Maniya Hina , Mori Priya , Kumar Vijay
Published: January 2025

Various studies have been conducted reporting the hypocholesterolemic effect of individual probiotic strains while only a few such reports are available on multi-strain probiotic formulation. In this study, 23 indigenous isolated probiotics were used to formulate multi-strain probiotic consortium after evaluating their co-culture potential. The study evaluated the antioxidant, lipolytic, hypocholesterolemic, and synergistic attributes of probiotic isolates for selection of the be compatible strains for effective consortium formulation. Limosilactobacillus fermentum BAB 7912 showed the highest antioxidant activity (30.22% DPPH radical reduction potential and 87.21% ABTS radical scavenging potential) among strains growing synergistically. The other strain of the final consortium Bacillus rugosus PIC5CR had the highest ferric reducing antioxidant potential (81.45%). Another probiotic isolate Bacillus rugosus PIB9CR was able to produce highest quantity of p-nitrophenol (272.61 ± 0.54 µM/15 min) as determined by p-nitrophenyl acetate method, indicating the higher lipolytic activity for both whole-cells and cell free supernatant (CFS). Hence, the multi-strain probiotic consortium consisting of these three strains was formulated that showed the significant cholesterol reductions potential (70.07% after 24 hours and 74.77% after 48 hours) which was higher than any of the single isolates used in this study. The strains and probiotic consortium demonstrated satisfactory cholesterol reduction and lipolytic activity, with isolates having higher co-culture attributes. Further investigation is needed to determine their viability as well as efficacy in an in-vivo model.
Metronidazole-induced neurotoxicity: is iron a contributing factor?
Authors: Bariweni Moses W , Patel Vinood B , Zariwala Gulrez M , Ozolua Raymond I
Published: January 2025

Background
Metronidazole-induced neurotoxicity is a rising challenge in the management of susceptible infections. The mechanisms involved in metronidazole-induced neurotoxicity are not fully unraveled. This study was aimed at determining the effect of metronidazole on iron homeostasis in SH-SY-5Y neuroblastoma cells.
Methods
Confluent SH-SY-5Y neuroblastoma cells were treated with 1, 10, 25, 50, 100, 250 µM concentrations of metronidazole only or in combination with 20 µM iron. DMSO or culture media was used as control. Viability and ferritin assay were conducted on the treated cells. The treatments were for 24 hr, 48 hr and 72 hr respectively.
Results
In the viability assay, doses of metronidazole reduced viability of SH-SY-5Y neuroblastoma cells in a time and concentration dependent manner. After 24 hr treatment, 250 µM metronidazole reduced (P < 0.001) cell viability while 50 µM, 100 µM and 250 µM metronidazole reduced (p < 0.01, p < 0.001) viability only after 48 and 72 hr compared with control. Doses of metronidazole 50 µM, 100 µM and 250 µM in 20 µM iron reduced viability in a time dependent manner in all the tests periods. Metronidazole also induced a time and concentration dependent increase (P < 0.05) in cellular iron uptake in the 48 and 72 hr treated cells in concentrations above 25 µM metronidazole.
Conclusion
It is concluded that metronidazole induces a time and concentration dependent iron overload and consequent cell death in SH-SY5Y neuroblastoma cells and this may contribute to the mechanism of metronidazole-induced neurotoxicity.
An in vitro one-pot synthetic biology approach to simulating diverging Golgi O-glycosylation of tumor-associated MUC1 from normal tissue MUC1
Authors: Naidoo Kevin , Nashed Abdullateef , Dilsook Kyllen , Senapathi Tharindu
Published: January 2025

Peptide O-glycosylation relies on the coordinated action of glycosyltransferases (GTs) within the endoplasmic reticulum (ER) and Golgi apparatus. An in vitro one-pot synthetic biology approach was developed to investigate the specificity and kinetics of GT O-GalNAc glycosylation that leads to tumor antigen glycoforms of mucin 1 (MUC1). The focus is to experimentally simulate the divergent glycosylation pathways that lead to the synthesis of cancer-associated antigens (Tn, T) and their sialylated derivatives. First, the biosynthetic details of the defining first step of GALNT relocation from the ER to the Golgi was modeled using the one-pot method. Our findings reveal that an ER enriched with GALNTs results in complete Galnac (Tn) MUC1 site occupancy. This comes about as a function of two processes that are i) extended GALNT reaction time and ii) prevention of inhibition by subsequent glycosylation enzymes such as C1GALT1. The modeling confirms that B3GNT6 has negligible specificity for MUC1 Tn, explaining the absence of core 3 and core 4 structures in MUC1 in both normal and cancerous breast cell lines. Moreover, ST6GALNAC1, and not ST6GALNAC2, is primarily responsible for α-2-6 sialylation of Tn and T antigens. Computer reaction dynamic simulations combined with kinetic experimental analysis show that ST6GALNAC1 prefers fully glycosylated MUC1 and more importantly that its preference is to sialyate the S9 and T13 sites in the SAPDTR motif. This is especially the case when the MUC1 concentration is high (i.e., high-level of expression), suggesting that sTn upregulation on MUC1 in cancer is linked to the occupancy status of S9 and T13 glycosylated sites, that were previously found to be cancer-associated. The results from the one-pot synthesis approach presented here demonstrate its ability to simulate cellular glycosylation within the Golgi-ER. This systems modelling unpacks the molecular details of enzyme localization and substrate glycan occupancy that is fundamental to the regulatory mechanisms that gives rise to tumor-associated MUC1 antigens.
Wood-water relationship and micro-chemical Properties of Huminated Archaeological European Elm (Ulmus laevis P.)
Authors: Ghavidel Amir , Wang Shennan , Bak Miklós , Rautkari Lauri , Hosseinpourpia Reza
Published: January 2025

Archaeological wood requires effective conservation to prevent further degradation, and traditional modifications such as polyethylene glycol (PEG) have limitations, including hygroscopicity and chemical degradation over time. To explore alternative modification, this study was conducted to investigate the suitability of humins, crosslinked with different concentrations of succinic acid (SA), to protect archaeological elm wood from the Agapia Monastery against water and to determine the modification mechanism. Key parameters such as dimensional stability, moisture sorption isotherms, and determination of accessible hydroxyl groups as a function of humination modification were analyzed using dynamic vapor sorption (DVS). The modification mechanism was studied by microstructural and chemical properties evaluation by Confocal-Raman spectroscopy and scanning electron microscopy (SEM). Results indicated that humins, particularly crosslinked with SA, significantly improved the water-related properties of wood and its dimensional stability. The humination also reduced the accessibility of the hydroxyl group, thus decreasing the equilibrium moisture content (EMC) of huminated elm at RHs ranging from 0 to 95%. While SEM images revealed structural changes in the modified wood. Confocal-Raman spectroscopy confirmed the successful allocation of humins into the cell walls. This study demonstrates that humins are promising materials for archaeological wood conservation, providing improvements in both chemical and physical properties.
Liver regeneration following partial hepatectomy in hepatocellular carcinoma: not only size matters
Authors: Long Haiyi , Wu Qingyu , Huang Jiayao , Zhong Xian , Xie Yuhua , Duan Yu , Xie Wenxuan , Chen Zebin , Li Dongming , Xie Xiaoyan , Su Liya , Lin Manxia
Published: January 2025

Background
To investigate factors associated with liver regeneration capacity in patients with hepatocellular carcinoma (HCC) after liver resection.
Methods
A total of 123 patients with HCC who underwent liver stiffness (LS) measurement by two-dimensional shear wave elastography (2D-SWE) before liver resection were retrospectively included. The future liver remnant (FLR) and postoperative liver volume (PLV) were measured. The standardized future liver remnant (sFLR), parenchymal hepatic resection rate (PHRR), and regeneration index (RI) were calculated. Patients were classified into two subgroups based on the extent of resection. Spearman correlation analysis was used to investigate factors associated with RI, and the receiver operating characteristic (ROC) curve was employed to evaluate the diagnostic performance of these relative factors to predict a significant liver regeneration (RI > 1).
Results
Strong correlation between RI and volume-related parameters, including FLR (r=-0.754, p < 0.001) and sFLR (r=-0.811, p < 0.001), were identified. Optimal cutoff values of 535ml for FLR and 0.452 for sFLR were used to predict a significant liver regeneration with an area under the curve (AUC) value of 0.967 and 0.980, respectively (all p < 0.001). In the high PHRR (> 50%) subgroup, LS was the only non-volume parameter correlating with RI (r=-0.526, p = 0.012). A cutoff value of 6.7kPa was used to predict a significant regeneration with an AUC value of 0.767 (p = 0.035).
Conclusions
The remnant volume was the key to liver regeneration after resection for HCC. LS may serve as a potential predictor for liver regeneration in those with extensive loss of parenchyma.
Cardiac fibrosis affects electrical conduction and arrhythmogenesis in a pacing-rate-dependent manner
Authors: Sacconi Leonardo , Giardini Francesco , Olianti Camilla , Marchal Gerrit Adam , Campos Fernando , Steyer Joshua , Madl Josef , Piersanti Roberto , Arecchi Giulia , Vanaja Induja Perumal , Biasci Valentina , Nesi Gabriella , Loew Leslie , Cerbai Elisabetta , Chelko Stephen , Regazzoni Francesco , Loewe Axel , Bishop Martin , Mongillo Marco , Kohl Peter , Zaglia Tania , Johnston Callum Michael
Published: January 2025

Cardiac fibrosis is a key factor in electrical conduction disturbances, yet its specific impact on conduction remains unclear, hindering predictive insight of cardiac electrophysiology and arrhythmogenesis. Among the different cardiac disorders, arrhythmogenic cardiomyopathy (ACM) is known to be associated with massive fibrotic remodelling of the myocardium, and it accounts for most cases of stress-related arrhythmic sudden death. To explore ACM further, we employed a Desmoglein-2-mutant mouse model and developed a correlative imaging approach to integrate macro-scale cardiac electrophysiology with 3D micro-scale reconstructions of the ventricles, to characterise the dynamics of conduction wavefronts and relate them to the underlying structural substrate. Our findings confirm that this ACM model shows localised replacement of cardiomyocytes with collagen and non-myocytes, contributing to electrical dysfunction. Moreover, we observed that conduction through fibrotic tissue areas shows a frequency-dependent behaviour, where conduction fails at high stimulation frequencies, promoting re-entrant arrhythmias, even in regions that were electrophysiologically inconspicuous at lower stimulation rates. Using a computational model, informed by high-resolution structural data, we found that frequency-dependent conduction through fibrotic tissue cannot be explained solely by collagen deposition or cardiomyocyte re-organisation. Indeed, fibrotic areas feature electrophysiological remodelling which acts as a low-pass filter for conduction, which can be quantitatively explained by electrotonic coupling of cardiomyocytes with non-myocytes. Collectively, our study provides a novel structure-function mapping pipeline and describes a previously unrecognised pro-arrhythmogenic mechanism in ACM, underscoring the need for dynamic assessment of functional conduction block in fibrotic myocardium using multiple diagnostic pacing protocols.