bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 6 from CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity
Authors: Haydar Dalia , Ibañez-Vega Jorge , Crawford Jeremy Chase , Chou Ching-Heng , Guy Clifford S. , Meehl Michaela , Yi Zhongzhen , Perry Scott , Laxton Jonathan , Cunningham Trevor , Langfitt Deanna , Vogel Peter , DeRenzo Christopher , Gottschalk Stephen , Roussel Martine F. , Thomas Paul G. , Krenciute Giedre
Published: December 2023

Supplementary Figure S6 shows experimental pipeline for single cell RNAseq experiment.
Supplementary Figure 5 from CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity
Authors: Haydar Dalia , Ibañez-Vega Jorge , Crawford Jeremy Chase , Chou Ching-Heng , Guy Clifford S. , Meehl Michaela , Yi Zhongzhen , Perry Scott , Laxton Jonathan , Cunningham Trevor , Langfitt Deanna , Vogel Peter , DeRenzo Christopher , Gottschalk Stephen , Roussel Martine F. , Thomas Paul G. , Krenciute Giedre
Published: December 2023

Supplementary Figure S5 shows murine CAR T cell expansion in media and after exposure to B7-H3-negative tumor cells.
Supplementary Figure 19 from CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity
Authors: Haydar Dalia , Ibañez-Vega Jorge , Crawford Jeremy Chase , Chou Ching-Heng , Guy Clifford S. , Meehl Michaela , Yi Zhongzhen , Perry Scott , Laxton Jonathan , Cunningham Trevor , Langfitt Deanna , Vogel Peter , DeRenzo Christopher , Gottschalk Stephen , Roussel Martine F. , Thomas Paul G. , Krenciute Giedre
Published: December 2023

Supplementary Figure S19 shows IHC for F4/80 and CD11c after BLZ945 and CAR T cell treatment, and OS post combination treatment.
Supplementary Figure 16 from CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity
Authors: Haydar Dalia , Ibañez-Vega Jorge , Crawford Jeremy Chase , Chou Ching-Heng , Guy Clifford S. , Meehl Michaela , Yi Zhongzhen , Perry Scott , Laxton Jonathan , Cunningham Trevor , Langfitt Deanna , Vogel Peter , DeRenzo Christopher , Gottschalk Stephen , Roussel Martine F. , Thomas Paul G. , Krenciute Giedre
Published: December 2023

Supplementary Figure S16 shows intracellular flow cytometry data from the endpoint tumors after CAR T cell treatment.
Supplementary Figure 11 from CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity
Authors: Haydar Dalia , Ibañez-Vega Jorge , Crawford Jeremy Chase , Chou Ching-Heng , Guy Clifford S. , Meehl Michaela , Yi Zhongzhen , Perry Scott , Laxton Jonathan , Cunningham Trevor , Langfitt Deanna , Vogel Peter , DeRenzo Christopher , Gottschalk Stephen , Roussel Martine F. , Thomas Paul G. , Krenciute Giedre
Published: December 2023

Supplementary Figure S11 shows dot plots depicting differentially expressed T cell genes in T cell clusters per treatment group.
Supplementary Figure 1 from CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity
Authors: Haydar Dalia , Ibañez-Vega Jorge , Crawford Jeremy Chase , Chou Ching-Heng , Guy Clifford S. , Meehl Michaela , Yi Zhongzhen , Perry Scott , Laxton Jonathan , Cunningham Trevor , Langfitt Deanna , Vogel Peter , DeRenzo Christopher , Gottschalk Stephen , Roussel Martine F. , Thomas Paul G. , Krenciute Giedre
Published: December 2023

Supplementary Figure S1 shows murine CAR T cell efficacy in vivo and Cd276 IHC post-treatment.
FIGURE 7 from CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity
Authors: Haydar Dalia , Ibañez-Vega Jorge , Crawford Jeremy Chase , Chou Ching-Heng , Guy Clifford S. , Meehl Michaela , Yi Zhongzhen , Perry Scott , Laxton Jonathan , Cunningham Trevor , Langfitt Deanna , Vogel Peter , DeRenzo Christopher , Gottschalk Stephen , Roussel Martine F. , Thomas Paul G. , Krenciute Giedre
Published: December 2023

Global Mac/MG depletion abrogates effective CAR T-cell responses. GL261 glioma-bearing mice were treated with BLZ945 at 200 mg/kg starting 5 days after tumor implantation. A, Experimental scheme of BLZ945 macrophage depletion kinetics experiment. Daily drug dosing via oral gavage was for 2 weeks and tumors were harvested for FACS analysis at days 9, 16, and 20 after tumor implantation. B, Summary plot showing frequency of TAMs infiltrating tumors as percentage of live CD45+ immune cells. C, Experimental scheme for combination study. Glioma-bearing mice were treated with BLZ945 at 200 mg/kg starting 5 days after tumor implantation and continued daily for 3 weeks. B7-H3 CAR T-cells with Ctrl or 28.mζ constructs were then injected intratumorally at day 16. D, Kaplan–Meier survival curve (n = 11, log-rank Mantel–Cox test with Bonferroni correction for multiple comparisons, ***, P < 0.001). E, Representative images from immunostaining for T-cell and macrophage markers from tumors at endpoint showing CD3 and Iba1 staining in brain samples from each treatment group at 40x magnification (scale bar = 100 µm). F, H-scores depicting quantitative analysis of CD3 and Iba1 staining in brain tumor samples at endpoint from E as evaluated by blinded pathologist.
FIGURE 1 from CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity
Authors: Haydar Dalia , Ibañez-Vega Jorge , Crawford Jeremy Chase , Chou Ching-Heng , Guy Clifford S. , Meehl Michaela , Yi Zhongzhen , Perry Scott , Laxton Jonathan , Cunningham Trevor , Langfitt Deanna , Vogel Peter , DeRenzo Christopher , Gottschalk Stephen , Roussel Martine F. , Thomas Paul G. , Krenciute Giedre
Published: December 2023

Generation and functional characterization of syngeneic B7-H3 CAR T-cells with different CAR structural designs. A, Scheme of mB7-H3-CAR constructs. Created with BioRender.com. B, MTS cytotoxicity assay against GL261 tumor cells at an E:T ratio of 0.25:1 (n = 7, mean ± SD, two-way ANOVA with Tukey test for multiple comparisons). C, T cells expressing different mB7-H3 CAR constructs were cocultured with GL261 tumor cells at a 2:1 ratio with restimulation every 3 days against fresh tumor cells until they no longer killed and/or expanded. Graphs show fold expansion of different T-cell donors upon successive stimulations (x-axis: each stimulation is a 3-day coculture with fresh GL261 tumor cells, n = 7). D, Summary of the maximum fold expansion of mB7-H3 CAR T-cells from individual donors upon repeat stimulation with GL261 tumor cells (n = 7, minimum to maximum range, one-way ANOVA with Tukey test for multiple comparisons). E, Maximum number of times CAR T-cells were able to kill Gl261 tumor cells (n = 7, minimum to maximum range, one-way ANOVA with Tukey test for multiple comparisons).
Auditory Spatial Discrimination and Sound Localization in Single-Sided Deaf Participants Provided with a Cochlear Implant
Authors: Ludwig Alexandra Annemarie , Meuret Sylvia , Battmer Rolf-Dieter , Fuchs Michael , Ernst Arneborg , Schönwiesner Marc
Published: December 2023

Introduction: Spatial hearing is most accurate using both ears, but accuracy decreases in persons with asymmetrical hearing between ears. In participants with deafness in one ear but normal hearing in the other ear (single-sided deafness [SSD]), this difference can be compensated by a unilateral cochlear implant (CI). It has been shown that a CI can restore sound localization performance, but it is still unclear to what extent auditory spatial discrimination can be improved. Methods: The present study investigated auditory spatial discrimination using minimum audible angles (MAAs) in 18 CI-SSD participants. Results were compared to 120 age-matched normal-hearing (NH) listeners. Low-frequency (LF) and high-frequency (HF) noise bursts were presented from 4°, 30°, and 60° azimuth on the CI side and on the NH side. MAA thresholds were tested for correlation with localization performance in the same participants. Results: There were eight good performers and ten poor performers. There were more poor performers for LF signals than for HF signals. Performance on the CI side was comparable to performance on the NH side. Most difficulties occurred at 4° and at 30°. Eight of the good performers in the localization task were also good performers in the MAA task. Only the localization ability at 4° on the CI side was positively correlated with the MAA at that location. Conclusion: Our data suggest that a CI can restore localization ability but not necessarily auditory spatial discrimination at the same time. The ability to discriminate between adjacent locations may be trainable during rehabilitation to enhance important auditory skills.
Pseudolinfoma na adolescência
Authors: Silva Caroline Pereira da , Jordão Juliana , Silva Bruna do Valle , Touso Maíra
Published: December 2023

Objetivo: Relatar um caso incomum de Pseudolinfoma Cutâneo na adolescência, não diagnosticado por aproximadamente oito anos. Método: As informações foram obtidas pela revisão do prontuário, entrevista com o paciente, registro fotográfico das lesões e dos métodos diagnósticos e revisão de literatura. O trabalho foi submetido e aprovado pelo Comitê de Ética em Pesquisa (CEP), número de aprovação 4.952.193, com autorização do paciente e seus responsáveis legais. Considerações Finais: o caso relatado evidencia a importância de um diagnóstico fidedigno e dos diagnósticos diferenciais, uma vez que a paciente apresentou a lesão por aproximadamente oito anos, sem receber nenhum diagnóstico e/ou tratamento. Além disso, não só a faixa etária é incomum, mas também a localizaçãoda lesão e por esta razão, as informações são fundamentais para auxiliar outros profissionais, com benefício deste estudo para o Sistema de Saúde.
Ansiedade dos profissionais da atenção primária à saúde na pandemia de COVID-19
Authors: Saliba Tânia Adas , Nascimento Carolina Carvalho Menez Pinto , Moimaz Suzely Adas Saliba , Garbin Cléa Adas Saliba , Saliba Nemre Adas
Published: December 2023

Fundamentos: O desequilíbrio entre o dever profissional e o medo na COVID-19 causaram instabilidade emocional nos trabalhadores da saúde. Objetivos: Avaliar a ansiedade dos profissionais da Atenção Primária à Saúde (APS) e fatores associados e analisar a percepções, positivas e negativas, da pandemia. Metodologia: Estudo transversaldescritivo-exploratório, quanti-qualitativo, com profissionais da APS, em município do Estado de São Paulo, Brasil, de dezembro/2020 a março/2021. Realizou-se estatística descritiva e aplicou-se, ao nível de 5%, o teste Qui-quadrado. Para o conteúdo textual, efetuou-se a análise léxica pela Classificação Hierárquica Descendente. Principais resultados: Foi identificado que mais de 50% dos participantes apresentaram ansiedade e ela esteve associada aofato de ter contraído COVID-19 (p-valor = 0.0327); à interferência nas atividades diárias (P-valor < 0.0001) e com a profissão (p-valor = 0.0483). Os pontos negativos foram a saúde mental; condições de trabalho; atendimentos e comportamento. Os positivos foram biossegurança, autocuidado e uso de equipamentos de proteção individual. Conclusões: A maioria dos profissionais da APS a presentou ansiedade e esteve associada aos fatores sociodemográficos. A pandemia trouxe pontos positivos e negativos na ótica dos profissionais da APS.
Espiritualidade e religião/religiosidade: as percepções das pessoas com doença renal crônica em tratamento hemodialítico
Authors: Paz Denise Barcelos de Pádua , Rozza Soraia Geraldo , Lima Hélder de Pádua , Cândido Viviane Cristina , Barboza Elton Santo
Published: December 2023

Objetivo: Descrever as percepções das pessoas em tratamento hemodialítico sobre a espiritualidade/ religião/religiosidade. Método: trata–se de um estudo descritivo de abordagem qualitativa. Foram entrevistados 28 renais crônicos em tratamento hemodialítico em duas unidades de hemodiálise de hospitais do estado do Mato Grosso do Sul entre abril e junho de 2022. Resultados: Os dados demonstraram na caracterização sociodemográfica que a maioria era do sexo feminino, casados, aposentados, as religiões católicos e evangélicos prevaleceram. Pelas falas dos entrevistados emergiram duas categorias: percepções sobre espiritualidade, fé e religião; a espiritualidade no enfrentamento da doença. Considerações finais: A análise dos depoimentos demonstrou percepções positivas na utilização da espiritualidade/religiosidade como método de enfrentamento perante adversidades vividas durante o tratamento hemodialítico. Com esses achados, ressaltamos a importância de implementar os cuidados na dimensão espiritual na sistematização daassistência de enfermagem no sentido de proporcionar alívio do sofrimento do portador de doença renal crônica.
Ficção em prosa
Authors: Virissimo José
Published: December 2023

Ficção em prosa de José Verissimo.
Espaço, encontro e legado – Lima Barreto e Osman Lins em diálogo
Authors: Hossne Andrea  Saad
Published: December 2023

O artigo pretende abordar como a leitura da obra de Lima Barreto por Osman Lins, além de revelar grande afinidade entre os escritores em vários aspectos literários e de visão de mundo, despertou também no pesquisador e professor o empenho na compreensão do espaço na literatura, levando, assim, não apenas a uma compreensão sensível da obra de Lima Barreto (um primeiro legado), mas também à formulação de uma perspectiva teórica acerca do Espaço como categoria literária, que ilumina tanto a obra de Lima Barreto e a do próprio Osman Lins, quanto fornece uma elaboração brasileira sobre essa categoria que transcende a obra de ambos, e até os dias de hoje permite aos estudiosos uma incursão profícua nos estudos que implicam essa categoria literária, qualquer que seja a obra abordada (um segundo legado).
Editorial
Authors: Pacheco Ana Paula , Silva Anderson Gonçalves da , Fonseca Maria Augusta
Published: December 2023

Editorial por Ana Paula Pacheco, Anderson Gonçalves da Silva, Maria Augusta Fonseca.
Gamificação como Metodologia Ativa de Avaliação: Relato de uma Experiência no Ensino Superior
Authors: Sancinetti Giselle Patrícia , Xavier Amanda Rezende Costa
Published: December 2023

Este artigo relata uma experiência do uso da gamificação como metodologia ativa de avaliação, em unidades curriculares de um curso de Engenharia Química, de uma universidade federal brasileira. A proposta avaliativa iniciou-se durante a suspensão das atividades presenciais na pandemia da Covid-19, em 2020, e continua sendo aplicada após o retorno ao ensino presencial. Pela busca de uma aprendizagem mais significativa, a docente optou por aplicar a gamificação como metodologia de avaliação em duas atividades avaliativas do semestre, a primeira e a última. Os estudantes, divididos em grupos foram incentivados a elaborar jogos sobre os conteúdos previamente abordados, sendo que esta metodologia tem estimulado a criatividade e o estudo dos assuntos, uma vez que, ao elaborar um jogo, a equipe responsável precisa avaliar a resposta e mostrar o resultado correto. Adicionalmente às atividades avaliativas grupais, foram aplicadas avaliações diagnósticas individuais ao final de cada capítulo (em um total de cinco), com o objetivo de avaliar a assimilação do conteúdo teórico pelo estudante. Os conceitos foram aplicados de forma integrada e ativa em exercícios práticos e, ainda, houve a manutenção dos seminários em grupo sobre uma empresa química. Os resultados da experiência, até o momento, sinalizam que os estudantes se tornaram protagonistas do seu processo de aprendizagem, a partir de evidências de seu aprendizado. Quando docente e estudantes estão inseridos no processo de ensino e aprendizagem de modo unificado percebe-se motivação e engajamento por parte de ambos, resultando numa aprendizagem mais eficaz quando comparado com as práticas tradicionais de ensino adotadas.
Birth-to-childhood tracking of linear growth and weight gain in the MINA-Brazil Study
Authors: Lourenço Bárbara Hatzlhoffer , Rodrigues Caroline Zani , Damasceno Ana Alice de Araújo , Cardoso Marly Augusto , Castro Marcia C.
Published: December 2023

OBJECTIVE: To investigate birth-to-childhood tracking of linear growth and weight gain across the distribution of length/height and weight for age z-scores and according to household wealth. METHODS: Data from 614 children from the MINA-Brazil Study with repeated anthropometric measurements at birth and up to age five years were used. Z-scores were calculated for length/height (HAZ) and weight (WAZ) according to international standards. Birth-to-childhood tracking was separately estimated using quantile regression models for HAZ and WAZ, extracting coefficients and 95% confidence intervals (95%CI) at the 25th, 50th, and 75th quantiles. In a subgroup analysis, we estimated tracking between birth and age two years, and between ages two and five years. To investigate disparities in tracking, interaction terms between household wealth indexes (at birth and age five years) and newborn size z-scores were included in the models. RESULTS: Tracking coefficients were significant and had similar magnitude across the distribution of anthropometric indices at age five years (HAZ, 50th quantile: 0.23, 95%CI: 0.11 to 0.35; WAZ, 50th quantile: 0.31, 95%CI: 0.19 –0.43). Greater tracking was observed between ages two and five years, with coefficients above 0.82. Significantly higher tracking of linear growth was observed among children from wealthier households, both at birth, at the lower bounds of HAZ distribution (25th quantile: 0.30, 95%CI: 0.13 – 0.56), a nd during childhood, in the entire HAZ distribution at five years. For weight gain, stronger tracking was observed at the upper bounds of WAZ distribution at age five years among children from wealthier households at birth (75th quantile: 0.59, 95%CI: 0.35–o 0.83) and during childhood (75th quantile: 0.54, 95%CI: 0.15 –0.93). CONCLUSION: There was significant tracking of HAZ and WAZ since birth, with indication of substantial stability of nutritional status between ages two and five years. Differential tracking according to household wealth should be considered for planning early interventions for preventing malnutrition.
Intensive Versus Traditional Cardiac Rehabilitation: Mortality and Cardiovascular Outcomes in a 2016–2020 Retrospective Medicare Cohort
Authors: Husaini Mustafa , Deych Elena , Waken R.J. , Sells Blake , Lai Andrew , Racette Susan B. , Rich Michael W. , Joynt Maddox Karen E. , Peterson Linda R.
Published: December 2023

BACKGROUND:

Traditional cardiac rehabilitation (CR) improves cardiovascular outcomes and reduces mortality, but less is known about the relative benefit of intensive CR (ICR) which incorporates greater lifestyle education through 72 sessions (versus 36 in CR). Our objective was to determine whether ICR is associated with a mortality and cardiovascular benefit compared with CR.

METHODS:

Retrospective cohort study of Medicare Fee-For-Service beneficiaries in a 100% sample, claims data set. Qualifying events were captured from May 1, 2016 to December 31, 2019 and ICR/CR utilization captured from May 1, 2016 to December 31, 2020. Among patients attending at least 1 day of either CR or ICR, Cox proportional hazards models using a 1 to 5 propensity score match were used to compare utilization and the association of ICR versus CR participation with (1) all-cause mortality and (2) cardiovascular-related hospitalizations or nonfatal cardiac events. Dose-response was assessed by the number of days attended.

RESULTS:

From 2016 to 2019, 1 277 358 unique patients met at least one qualifying indication for ICR/CR from 2016 to 2019. Of these, 262 579 (20.6%) and 4452 (0.4%) attended at least one session of CR or ICR, respectively (mean [SD] age, 73.2 [7.8] years; 32.3% female). In the matched sample, including 26 659 total patients (median, 2.4-year follow-up), ICR was associated with 12% lower all-cause mortality (multivariable adjusted hazard ratio, 0.88 [95% CI, 0.78–0.99];
P
=0.036) compared with CR but no significant difference for cardiovascular-related hospitalization or nonfatal cardiac events. The mortality benefit was seen for both ICR and CR per day strata, with each modality demonstrating a clear dose-response benefit.

CONCLUSIONS:

ICR is associated with lower mortality than traditional CR among Medicare beneficiaries but no difference in cardiovascular-related hospitalization or nonfatal cardiac events. Moreover, ICR and CR demonstrate a dose-response relationship for mortality. Additional studies are needed to confirm these observations and to better understand the mechanisms by which ICR may lead to a reduction in mortality.
Armenia and Iran
Authors: Cereti Carlo G.
Published: December 2023

This paper focuses on the worship of Anāhitā in Western Asia examining some of the ideas put forward by James R. Russel in his volume on Zoroastrianism in Armenia in the light of more recent discussions about the role played by the goddess in Armenian religion before the conversion of the country to Christianity. While the evidence from more ancient periods has also been briefly presented, specific attention is given to Anāhīd’s worship in the Sasanian period and to the devotion of Narseh to this divinity. Finally, Middle Persian personal names containing the theonym Anāhīd are briefly introduced and discussed, showing that this important divinity is underrepresented in Sasanian and post-Sasanian onomastics.
An Unknown Source on Proselytism among the Udis
Authors: Arakelova Victoria , Hakobyan Hayk
Published: December 2023

This paper presents the English translation with commentaries of some interesting passages from the unpublished manuscript by Abgar Payazat, an Armenian-Udi intellectual of the beginning of the 20th century. He particularly describes episodes of proselytism among the Udis from the Armenian Apostolic Church to the Russian Orthodoxy. The manuscript itself, is an attempt of compiling a grammar of the Udi language in Armenian.
Normative Framework for the Regulation of Holdout Creditors in the Sovereign Debt Market
Authors: Oluyeju Maria , Oluyeju Olufemi
Published: December 2023

This article challenges the contemporary negative and dismissive narratives about distressed debt hedge funds (DDHFs), a subset of holdout creditors. A soft normative framework for regulating this category of creditors and other holdout creditors is however proposed to address their disruptive activities in the sovereign debt market. It is proposed that the Basel III framework be a conduit for enforcing the proposed normative framework because hedge funds are customers of institutions subject to Basel III oversight. One of the characteristics of these funds is their relatively sophisticated and high use of leverage. The authors therefore envisage the Basel III framework being expanded to provide for enforcement in this context. Finally, the normative framework proposed in this article differs from previous proposals including the Sovereign Debt Restructuring Mechanism (SDRM) and contractual solutions including Collective Action Clauses (CACs) and exit consents as it proposes the Basel III framework as an enforcement mechanism and is not a contractual solution.
Šaraf, charité et pauvreté : aperçu d’une histoire sociale des chorfa au Maroc (années 1860-années 1930)
Authors: Perrier Antoine
Published: December 2023

Moroccan chorfa are presented as a group defined less by their sociology than by a common genealogy. By examining a corpus of administrative archives from the Makhzen, then from the colonial state, we aim to examine the links between šaraf and poverty, and to explore manifestations of material distress or collective generosity towards the chorfa. Without stopping at the break with the establishment of the protectorate, this article shows the chorfa’s continued privileged place in assisting the poor and the persistence of a statutory definition of the right to assistance, which has as much to do with spiritual humility as with a hereditary right to alms. This continuity illustrates the coherence of the group, despite its social heterogeneity, and its political usefulness for the Makhzen, which wished to preserve its chorfa from an indigence that was too perilous. It also shows that «poverty» in Moroccan society can never be reduced to mere material misery.
« Les Historiens des Chorfa ». Deux ouvrages généalogiques sur les chorfa marocains à l’époque contemporaine (fin XIXe siècle-fin XXe siècle)
Authors: Mayeur-Jaouen Catherine
Published: December 2023

During early modern period, general censuses and genealogical works on the Moroccan genealogies of the descendants of the prophets (šurafāʾ, ašrāf) were often commissioned by sultans. Printed at the very end of the nineteenth century, al-Faḍīlī’s al-Durar al-bahiyyah was written at the request of the sultan Mawlāy Hasan. It compiled previous genealogical works of the early modern period and major genealogical sources of the nineteenth century. During the twentieth century, the last major survey of ašrāf families in Morocco is Maṣābīḥ al-bašariyyah, published in 1408/1987: it significantly describes the transformation of ašrāf families into urban elites of modern Morocco and their migration to the large cities of northern Morocco. This paper will explain the methods of investigation and classification described in al-Durar al-bahiyyah and Maṣābīḥ al-bašariyyah.
Gassendi and the Dutch: From the Parhelia Affair to the Reception of the Disquisitio metaphysica
Authors: Verbeek Theo
Published: December 2023

The Dutch reception of Gassendi is determined on the one hand by his journey to the United Provinces in 1629 and on the other by his works as they were published from 1624 to 1656. With much of it I dealt in earlier publications. What I present here are some supplementary remarks and a closer consideration of, presumably, the last Dutch ‘Gassendist’, Gerardus de Vries (1648–1705).
Bayle on Gassendi: The History and Theory of Atomism
Authors: Collacciani Domenico
Published: December 2023

In this article, I explore the role that Gassendi’s philosophy plays in Pierre Bayle’s work. Bayle often quotes Gassendi, as much in the Œuvres diverses as in the Dictionnaire. Despite their stylistic differences, the two authors share a sceptical stance that is supported by considerable erudition. First, I demonstrate that Gassendi is an important source of historical information and philological observations. Second, I discuss the thesis of ensouled atoms that Bayle formulates on several occasions in his articles on ancient atomism and argue that the hypothesis constitutes a polemical stance against modern atomism. In particular, it provides grounds for a critique of the definition of the weight of atoms in the Syntagma. I suggest that according to Bayle, the notion of materia actuosa must be refuted on the grounds that it may render the generation of sentient life inconceivable.
Redefining “Core Competencies”: Labor Market Intermediation in Outsourced Warehouses
Authors: Gutelius Beth , Theodore Nik
Published: December 2023

For nearly a half century, questions of why and how firms navigate the “make-buy” decision have animated fields as varied as industrial relations and economic geography. The idea of “core competencies” became the dominant explanation of corporate decision-making processes, where any activity deemed outside of the central specializations of the firm is a possible candidate for outsourcing. Coupled with the focus on short-term profit taking, corporate leaders have grown increasingly focused on shedding less-profitable activities and shifting supply-chain risk—leading to high levels of lead-firm influence over subcontracting markets and the cost-based competition that permeates them. This paper examines the role of third-party logistics companies (3pl s) in the warehousing sector. It argues that efforts to contain operational costs increasingly are focused on labor and that the ability to access and deploy low-cost labor is among the “core competencies” touted by many 3pl s in the warehousing sector.
The Loser’s Long Curse: How Exposure to Class Conflict Shapes Election Outcomes
Authors: Meriläinen Jaakko , Mitrunen Matti
Published: December 2023

Understanding the political consequences of civil war exposure is a challenging task, given the myriad of overlapping and at times divergent mechanisms involved. This article provides evidence of the persistent political legacy stemming from exposure to a violent class conflict. We revisit the Finnish Civil War of 1918 and first trace out the impact of local conflict exposure on electoral outcomes over a quarter-century period between the World Wars. To do so, we combine a difference-in-differences approach with historical data on the geographical distribution of civil war casualties and election outcomes. We document that the local electoral performance of left-wing parties that were associated with the insurgents was persistently and negatively affected by civil war casualties on both sides of the conflict. We also discuss potential mechanisms behind this finding and further show that the civil war had an enduring impact on the Finnish political landscape over a hundred years.
Dominant group backlash? Majority responses to minority participation in the police
Authors: Nanes Matthew
Published: December 2023

Security sector reform often involves integrating marginalized groups into the police. Extensive discussion surrounds the benefits of inclusion to the marginalized group, but we know little about impacts on the dominant group. I argue that exposure to out-group police can increase dominant group civilians’ trust in the out-group, opening the door for further reforms and increasing the likelihood of peace. I explore dominant group citizens’ responses to out-group police officers in Israel. First, using a survey experiment, I find no evidence that exposure to Arab (marginalized) police officers leads to backlash by Jewish (dominant) civilians. Then, drawing on multiple surveys and panel data on the identity of officers at every station over six years, I find that exposure to Arab police is associated with increased trust in Arabs among Jews. This trust extends to both everyday situations like willingness to live next door to an Arab and to beliefs about Arabs’ intentions to commit political violence. Collectively, these results contradict fears that backlash by the dominant group might spoil peace, opening the door for police integration as an important part of peace processes.
Book review: Sudha Pai and Sajjan Kumar, Maya, Modi, Azad: Dalit Politics in the Time of Hindutva
Authors: Mehra Ajay K.
Published: December 2023

Sudha Pai and Sajjan Kumar, Maya, Modi, Azad: Dalit Politics in the Time of Hindutva, HarperCollins Publishers, 2023, 310 pp., ₹599, ISBN 9789356296893 (Paperback).
Science and/as work: An introduction to this special issue
Authors: Roberts Lissa , Rockman Seth , Hui Alexandra
Published: December 2023

This brief essay introduces a special issue dedicated to exploring two themes: “science and work” and “science as work.” Following a brief overview of these two themes, it briefly describes the other contributions to the special issue.
Depression and its associated factors: A comparison between congenital and acquired physical disabilities
Authors: Kim Agnus M , Park Jae-Hyun
Published: December 2023

Objective

While depression associated with disability has been extensively studied, how depression could differ depending on whether the disability is congenital or acquired remains to be investigated. The objective of this study was to compare depression and related factors among people with congenital and acquired physical disabilities.

Methods

We used the 2016 Panel Survey of Employment for the Disabled in Korea, a population-based survey for people with disability registered with the Korean government. Among 4577 participants, a total of 2128 participants with physical disability were analyzed using chi-square and binary logistic regression analysis.

Results

The prevalence of depression was 12.9% in those with congenital physical disability and 16.0% in those with acquired physical disability. Stress due to disability and family relationship satisfaction were associated with higher and lower odds of depression, respectively, in both disability groups. Discrimination due to disability, divorce, social participation, and subjective social status were significant predictors of depression only in people with acquired disability.

Conclusions

Compared to those with congenital disability, individuals with acquired disability can be more susceptible to issues relating to social relationships, social standing and discrimination. Findings of this study suggest that acquired disability and adapting to changes associated with it can be a source of mental distress in addition to living with it. Efforts are needed to address discrimination, provide supportive social relationships, and provide supportive living conditions in order to reduce depression in persons living with disability, especially those with acquired disability.
Enhancing the fracture toughness of laminated composites through loop warp yarns
Authors: Shao Mingyang , Cai Deng’an , Zhang Nan , Yu Qihang , Hu Fangtian , Kuang Ning , Zhou Guangming
Published: December 2023

The delamination tendency is a key factor affecting the practical use of laminated composites. How to improve the interlaminar strength and interlaminar fracture toughness of laminated composite is a focus of research on composite materials. A three-dimensional (3D) weaving technique is employed to weave loop warp yarns (loops) with 3D fiber bundles instead of warp yarns on the basis of plain fabrics. The contribution of loops to the interlayer performance is revealed by double cantilever beam (DCB) tests, end-notch flexure (ENF) tests, flexural tests, and double notch shear (DNS) tests. Test results show that the mode I and mode II interlaminar fracture toughness values of the single-sided-loop two-dimensional (2D) woven laminated composite (SWLC) are 77% and 58.2% higher than the interlaminar fracture toughness values of the general 2D woven laminated composite (GWLC). As companied with the ones of GWLC, flexural strength and modulus of SWLC increase by 73% and 69.1%, and the interlaminar shear strength of SWLC increases by 45.7%. The loop yarns act as a link between the interlaminar matrix and the reinforcing fiber fabric and thus improve the poor interlaminar performance of GWLC. The reported information may provide a reference for the application of the SWLC in practice.
Who Cares for Families? Narrative(s) of Return in Postsocialist Europe
Authors: Zaharijević Adriana , Wawrzyniak Joanna , Dohotariu Anca
Published: December 2023

This introduction to the thematic cluster “Who Cares for Families? Narrative(s) of Return in Postsocialist Europe” identifies and analyzes its core concept—the narrative of return. Families of today are talked about differently, and how they are narrativized matters. The narrative that stresses that family is under threat and in need of defense or a special form of care, figuring care as restitution of the natural, traditional, or proper family, is termed the narrative of return. The trope of return is strongly normative and non-descriptive, as it relies on mythical temporalities that ought to be restored in our present. The article first defines the choice of concepts—narrative, return, care, and threat. Second, it applies this conceptual frame in the transnational context, particularly within the transnational anti-gender campaigns in the populist moment. Third, it focuses on the postsocialist part of Europe, where, as the entire thematic cluster aims to demonstrate, the narrative of return has gained particular currency. In eastern Europe, these narratives are integral to larger projects of restoration of national agendas and serve as a tool of double emancipation: from the Soviet past and from the present European Union. Political actors using narratives of return advocate and successfully push through fundamental changes in the political frameworks and value systems of the postsocialist countries. In sum, the introduction aims to demonstrate the conceptual background of a political tool.
Between- and within-person longitudinal associations between personality traits and social support across relationships during older adulthood
Authors: Hill Patrick L , Pfund Gabrielle N , Allemand Mathias , Kivi Marie , Berg Anne Ingeborg , Thorvaldsson Valgeir , Hansson Isabelle
Published: December 2023

The current study investigated how perceived social support was associated with personality trait development in a Swedish longitudinal sample ( n = 3914; mean age = 63.09 years) with six waves of data on individuals’ Big Five personality traits, and perceived support from family, friends, and a special someone. We employed random intercept cross-lagged panel models to consider the between- and within-person associations for these constructs over time. First, in almost all cases, between-person associations were found between the levels for personality traits and support variables. Moreover, findings did not differ much depending on the source of the relationship. Second, again in almost every model, significant within-person covariances were evidenced, suggesting that when individuals increased on support relative to their typical level at a given wave, they also tended to report higher levels than they typically do on these traits. Finally, however, little evidence was found for cross-lagged effects in either direction. Across models, only one cross-lagged association even reached significance. In sum, our findings support the close connection between personality and perceived social support in older adulthood, and they motivate future directions into when and why such associations occur using more proximal measurements.
Terminal sliding mode control based on recursive stochastic configuration network for ball mill lining replacement process
Authors: Tang Yunze , Qiao Jinghui , Chen Yuxi
Published: December 2023

The precise control of multi-joint manipulators presents significant challenges in the context of replacing internal liners of large grinding machines. These challenges arise due to the uncertainty of system parameters and external disturbance. A terminal sliding mode control based on a recursive stochastic configuration network is proposed to ensure that the system is stable, and it reduces system oscillations in this article. In addition, a disturbance observer based on recursive stochastic configuration network is designed to estimate and compensate for the uncertainties in the system, thereby improving the robustness of the system. To enhance the realism of the simulations, the simulation modeling process incorporated uncertainty parameters and external disturbance information. The simulation results demonstrated the effectiveness of the proposed terminal sliding mode control approach in meeting the practical control requirements. This accomplishment presents a valuable new method for controlling mechanical arms. The method is applicable under conditions of system uncertainty and external disturbance.
Toward a Better Understanding of G4 Evolution in the 3 Living Kingdoms
Authors: Vannutelli Anaïs , Ouangraoua Aïda , Perreault Jean-Pierre
Published: December 2023

Background:

G-quadruplexes (G4s) are secondary structures in DNA and RNA that impact various cellular processes, such as transcription, splicing, and translation. Due to their numerous functions, G4s are involved in many diseases, making their study important. Yet, G4s evolution remains largely unknown, due to their low sequence similarity and the poor quality of their sequence alignments across several species. To address this, we designed a strategy that avoids direct G4s alignment to study G4s evolution in the 3 species kingdoms. We also explored the coevolution between RBPs and G4s.

Methods:

We retrieved one-to-one orthologous genes from the Ensembl Compara database and computed groups of one-to-one orthologous genes. For each group, we aligned gene sequences and identified G4 families as groups of overlapping G4s in the alignment. We analyzed these G4 families using Count, a tool to infer feature evolution into a gene or a species tree. Additionally, we utilized these G4 families to predict G4s by homology. To establish a control dataset, we performed mono-, di- and tri-nucleotide shuffling.

Results:

Only a few conserved G4s occur among all living kingdoms. In eukaryotes, G4s exhibit slight conservation among vertebrates, and few are conserved between plants. In archaea and bacteria, at most, only 2 G4s are common. The G4 homology-based prediction increases the number of conserved G4s in common ancestors. The coevolution between RNA-binding proteins and G4s was investigated and revealed a modest impact of RNA-binding proteins evolution on G4 evolution. However, the details of this relationship remain unclear.

Conclusion:

Even if G4 evolution still eludes us, the present study provides key information to compute groups of homologous G4 and to reveal the evolution history of G4 families.
Tourism and economic development: A literature review to highlight main empirical findings
Authors: Alcalá-Ordóñez Alejandro , Segarra Verónica
Published: December 2023

After the publication of a significant number of papers analyzing the tourism-led growth hypothesis (TLGH), a new line has arisen within the scientific literature, which attempts to analyze the capacity of tourism as an instrument of economic development, given that this concept has been widely linked to both economic aspects and socio-economic conditions of the resident population. Because of the new line mentioned, this work reviews 57 published articles (from 2005 to 2022) that examined the relationship between tourism and economic development. Specifically, the empirical results of the reviewed works suggest that tourism has positive effects on socio-economic development, acting as a tool that reduces poverty, lessens inequalities, and improves the living conditions of the resident population. In line with this, papers reviewed suggests different policy recommendations as promote access to financing, trade, campaigns for tourism or major relevance of public and private sector investments.
Surviving colonialism? A response to Neither Settler nor Native
Authors: Abu El-Haj Nadia
Published: December 2023

This article engages Mahmood Mamdani's arguments in Neither Settler nor Native from the perspective of the question of Palestine. Sympathetic with his call to “decolonize the political” by severing nation from state, I, nevertheless, query his proposal to abandon, a priori, binaries such as “settler/native” and “perpetrator/victim” in order to achieve a decolonized state and polity. The unifying concept of the “survivor” that he proposes—that we are all survivors of the ravages of political modernity, I argue, has its own history and grammar of injury, victimhood, and identity that is not easily abandoned and certainly not in the context of Palestine. How might one achieve justice—redistributive justice, that is, rather than mere reconciliation—if political demands cannot be made in the name of the collectives (in this instance, Palestinians) who have suffered the displacement and violence of settler-colonialism? We might need to hold onto such binaries—even if only for a time and even as we recognize that what it means to be a “settler” does not remain stable over time—in order to decolonize the political in substantive rather than merely formal terms.
Delivering HIV prevention medication online: Findings from a qualitative study exploring the acceptability of an online HIV pre-exposure prophylaxis (PrEP) care pathway among service users and healthcare professionals
Authors: Kincaid Ross , Gibbs Jo , Dalrymple Jenny , Henderson Lindsay , Frankis Jamie , Estcourt Claudia
Published: December 2023

Objective

Eliminating HIV transmission worldwide could become a reality with the advent of HIV pre-exposure prophylaxis (PrEP) where people take HIV medication to prevent HIV acquisition. Incorporating digital health into PrEP provision could help services scale up and meet increasing demand. We aimed to explore the prospective acceptability of a novel online PrEP care pathway (the ePrEP clinic) among PrEP users and healthcare professionals. The ePrEP clinic is composed of online postal self-sampling for HIV and other sexually transmitted infections, an online consultation, and remote medication provision.

Methods

We conducted semi-structured interviews with 15 PrEP users recruited from a large sexual health service and online cohort, and focus groups with nine healthcare professionals from the same sexual health service (May to December 2021). We analysed data using framework analysis.

Results

Participants found the ePrEP clinic highly acceptable, anticipating that it would provide convenience, empower PrEP users, and increase capacity within sexual health services. The need for blood self-sampling was a considerable barrier for some. Participants anticipated that the ePrEP clinic would be appropriate for established PrEP users with adequate digital health literacy and no medically significant conditions requiring in-clinic monitoring. Participants highlighted the need for support, including access to in-clinic care, and the integration of the ePrEP clinic within existing services.

Conclusions

Our findings provide clear justification for the development of the ePrEP clinic as an addition to in-clinic PrEP care pathways and provide useful insights for those developing digital services for other conditions incorporating testing, consultations, and prescribing.