bluuebunny/crossref_metadata_2025 huggingface dataset:
Active compensation for optimal RMS wavefront error in perturbed off-axis optical telescopes using nodal aberration theory
Authors: Wen Ming , Han Chengshan , Ma Hongcai
Published: January 2021

This paper presents an active compensation strategy for RMS wavefront error of perturbed off-axis telescopes in the framework of nodal aberration theory. First, the orthogonalized expression of the wave aberration function in the vector form for perturbed off-axis telescopes is derived by using RMS normalization. The orthogonalized aberration function is applied to analytically describe the RMS wavefront error in perturbed off-axis telescopes with circular apertures. Then, the system compensation model for perturbed off-axis telescopes is established. The compensation model takes the weighted square sum of the RMS wavefront errors at representative field points as the objective function, which is minimized to obtain the optimal compensation solution of off-axis systems with perturbation constraints. The compensation model is solved by using a particle swarm optimization algorithm. Then, the off-axis three-mirror anastigmatic telescope is taken as an example, and the system compensations for the misaligned tertiary mirror and deformed primary mirror are discussed. After compensation, the average RMS wavefront errors in the perturbed off-axis systems are greatly reduced, which can well meet the system requirements. Finally, Monte Carlo simulations of the optimal compensation method and sensitivity table method are carried out to demonstrate the correctness and accuracy of the proposed method.
Opto-mechanical design and calibration of a hyperspectral irradiance monitor
Authors: Huang Xionghao , Li Xin , Wang Yang , Zheng Xiaobing , Liu Enchao , Kang Qing
Published: January 2021

A hyperspectral irradiance monitor (HIM) is designed to measure the direct solar spectral irradiance on the ground, which can be used for research on climate change and vicarious calibration. The spectrometer uses a Féry prism to disperse and converge light, and a linear image sensor (NMOS) measures the spectral irradiance ranging from 400 nm to 1100 nm. The instrument utilizes two flat mirrors to fold the optical path, and optical software is used to optimize the key parameters. The dispersion equation of the prism and two characteristic wavelengths of the laser are utilized for the spectral calibration, for which the uncertainty of the spectral calibration is less than 0.8 nm. A standard lamp is used for the spectral irradiance calibration, for which the uncertainty of the spectral irradiance calibration is less than 2.78% (

k

=

2

). The instrument runs stably in the field.
Double-peak one-dimensional photonic crystal cavity in parallel configuration for temperature self-compensation in sensing
Authors: Haron Mohamad Hazwan , Berhanuddin Dilla Duryha , Majlis Burhanuddin Yeop , Md. Zain Ahmad Rifqi
Published: January 2021

We designed and demonstrated a double-peak one-dimensional photonic
crystal (1D PhC) cavity device by integrating two 1D PhCs cavities in
a parallel configuration. The device design is proposed so that it can
be used for bio-sensing purposes and has a self-compensation ability
to reduce the measurement error caused by the change of the
surrounding temperature. By combining two light resonances, two
resonance peaks are obtained. The peak’s separation, which gives the
initial value for a sensing system, can be controlled by varying the
cavity length difference (Δc) between the first and second 1D PhCs in
parallel. Then, by making one arm of the device as the reference arm
and the other arm as the sensing arm, the temperature
self-compensation device can be realized. The design and simulation of
this device are done by using Lumerical software, which are Lumerical
MODE, Lumerical finite-difference time-domain, and Lumerical
Interconnect. Electron-beam-lithography and deep reactive-ion-etching
processes were used for device fabrication. The experimental results
show the controllable peaks’ separation, which solves the double-peak
requirement for a temperature self-compensated bio-sensor design.
Polarization-driven semantic segmentation via efficient attention-bridged fusion
Authors: Xiang Kaite , Yang Kailun , Wang Kaiwei
Published: January 2021

Semantic segmentation (SS) is promising for outdoor scene perception in safety-critical applications like autonomous vehicles, assisted navigation and so on. However, traditional SS is primarily based on RGB images, which limits the reliability of SS in complex outdoor scenes, where RGB images lack necessary information dimensions to fully perceive unconstrained environments. As a preliminary investigation, we examine SS in an unexpected obstacle detection scenario, which demonstrates the necessity of multimodal fusion. Thereby, in this work, we present EAFNet, an Efficient Attention-bridged Fusion Network, to exploit complementary information coming from different optical sensors. Specifically, we incorporate polarization sensing to obtain supplementary information, considering its optical characteristics for robust representation of diverse materials. By using a single-shot polarization sensor, we build the first RGB-P dataset which consists of 394 annotated pixel-aligned RGB-polarization images. A comprehensive variety of experiments shows the effectiveness of EAFNet to fuse polarization and RGB information, as well as its flexibility to be adapted to other sensor combination scenarios.
Spectrally resolved optical beam-induced current imaging of ESD induced defects on VCSELs
Authors: Hsu Che-Lun , Das Subir , Wu Yen-Hsiang , Kao Fu-Jen
Published: January 2021

Optical beam-induced current (OBIC) mapping is widely used to characterize semiconductor lasers, particularly for failure analysis, in which the reliability has been a critical issue to be resolved spectrally and temporally. OBIC microscopy is advantageous for its non-invasiveness, when compared with electron beam-induced current (EBIC) microscopy. However, for high-speed devices, conventional OBIC methods may be limited in observing the spectral responses adequately. In this work, we present a modified OBIC microscopy based on a tunable ultrafast laser, to address the need for spectral resolving for precision failure spot analysis in vertical-cavity surface-emitting laser (VCSEL) diodes. The spectral OBIC response of VCSEL diodes is investigated by varying the irradiation wavelengths. Importantly, the ultrafast mode-locked laser provides broadband wavelength range to investigate photocurrent responses of the VCSELs sample. Specifically, the OBIC, electroluminescence (EL) detection, and the reflectance of the normal and the electrostatic discharge (ESD) damaged VCSELs are compared. We have found the ESD damaged VCSELs showing a redshifted spectral response.
The BMP signaling gradient is interpreted through concentration thresholds in dorsal–ventral axial patterning
Authors: Greenfeld Hannah , Lin Jerome , Mullins Mary C.
Published: January 2021

Bone Morphogenetic Protein (BMP) patterns the dorsal–ventral (DV) embryonic axis in all vertebrates, but it is unknown how cells along the DV axis interpret and translate the gradient of BMP signaling into differential gene activation that will give rise to distinct cell fates. To determine the mechanism of BMP morphogen interpretation in the zebrafish gastrula, we identified 57 genes that are directly activated by BMP signaling. By using Seurat analysis of single-cell RNA sequencing (scRNA-seq) data, we found that these genes are expressed in at least 3 distinct DV domains of the embryo. We distinguished between 3 models of BMP signal interpretation in which cells activate distinct gene expression through interpretation of thresholds of (1) the BMP signaling gradient slope; (2) the BMP signal duration; or (3) the level of BMP signal activation. We tested these 3 models using quantitative measurements of phosphorylated Smad5 (pSmad5) and by examining the spatial relationship between BMP signaling and activation of different target genes at single-cell resolution across the embryo. We found that BMP signaling gradient slope or BMP exposure duration did not account for the differential target gene expression domains. Instead, we show that cells respond to 3 distinct levels of BMP signaling activity to activate and position target gene expression. Together, we demonstrate that distinct pSmad5 threshold levels activate spatially distinct target genes to pattern the DV axis.
Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels
Authors: Waclawiková Barbora , Bullock Amber , Schwalbe Markus , Aranzamendi Carmen , Nelemans Sieger A. , van Dijk Gertjan , El Aidy Sahar
Published: January 2021

Microbial conversion of dietary or drug substrates into small bioactive molecules represents a regulatory mechanism by which the gut microbiota alters intestinal physiology. Here, we show that a wide variety of gut bacteria can metabolize the dietary supplement and antidepressant 5-hydroxytryptophan (5-HTP) to 5-hydroxyindole (5-HI) via the tryptophanase (TnaA) enzyme. Oral administration of 5-HTP results in detection of 5-HI in fecal samples of healthy volunteers with interindividual variation. The production of 5-HI is inhibited upon pH reduction in in vitro studies. When administered orally in rats, 5-HI significantly accelerates the total gut transit time (TGTT). Deciphering the underlying mechanisms of action reveals that 5-HI accelerates gut contractility via activation of L-type calcium channels located on the colonic smooth muscle cells. Moreover, 5-HI stimulation of a cell line model of intestinal enterochromaffin cells results in significant increase in serotonin production. Together, our findings support a role for bacterial metabolism in altering gut motility and lay the foundation for microbiota-targeted interventions.
Tai Chi training’s effect on lower extremity muscle co-contraction during single- and dual-task gait: Cross-sectional and randomized trial studies
Authors: Wayne Peter M. , Gow Brian J. , Hou Fengzhen , Ma Yan , Hausdorff Jeffrey M. , Lo Justine , Rist Pamela M. , Peng Chung-Kang , Lipsitz Lewis A. , Novak Vera , Manor Brad
Published: January 2021

Background

Tai Chi (TC) mind-body exercise has been shown to reduce falls and improve balance and gait, however, few studies have evaluated the role of lower extremity muscle activation patterns in the observed benefits of TC on mobility.

Purpose

To perform an exploratory analysis of the association between TC training and levels of lower extremity muscle co-contraction in healthy adults during walking under single-task (ST) and cognitive dual-task (DT) conditions.

Methods

Surface electromyography of the anterior tibialis and lateral gastrocnemius muscles was recorded during 90 sec trials of overground ST (walking normally) and DT (walking with verbalized serial subtractions) walking. A mean co-contraction index (CCI), across all strides, was calculated based on the percentage of total muscle activity when antagonist muscles were simultaneously activated. A hybrid study design investigated long-term effects of TC via a cross-sectional comparison of 27 TC experts and 60 age-matched TC-naïve older adults. A longitudinal comparison assessed the shorter-term effects of TC; TC-naïve participants were randomly allocated to either 6 months of TC training or to usual care.

Results

Across all participants at baseline, greater CCI was correlated with slower gait speed under DT (β(95% CI) = -26.1(-48.6, -3.7)) but not ST (β(95% CI) = -15.4(-38.2, 7.4)) walking. Linear models adjusting for age, gender, BMI and other factors that differed at baseline indicated that TC experts exhibited lower CCI compared to TC naives under DT, but not ST conditions (ST: mean difference (95% CI) = -7.1(-15.2, 0.97); DT: mean difference (95% CI) = -10.1(-18.1, -2.4)). No differences were observed in CCI for TC-naive adults randomly assigned to 6 months of TC vs. usual care.

Conclusion

Lower extremity muscle co-contraction may play a role in the observed benefit of longer-term TC training on gait and postural control. Longer-duration and adequately powered randomized trials are needed to evaluate the effect of TC on neuromuscular coordination and its impact on postural control.

Trial registration

The randomized trial component of this study was registered at ClinicalTrials.gov (NCT01340365).
Perceptual expertise with Chinese characters predicts Chinese reading performance among Hong Kong Chinese children with developmental dyslexia
Authors: Wong Yetta Kwailing , Tong Christine Kong-Yan , Lui Ming , Wong Alan C.-N.
Published: January 2021

This study explores the theoretical proposal that developmental dyslexia involves a failure to develop perceptual expertise with words despite adequate education. Among a group of Hong Kong Chinese children diagnosed with developmental dyslexia, we investigated the relationship between Chinese word reading and perceptual expertise with Chinese characters. In a perceptual fluency task, the time of visual exposure to Chinese characters was manipulated and limited such that the speed of discrimination of a short sequence of Chinese characters at an accuracy level of 80% was estimated. Pair-wise correlations showed that perceptual fluency for characters predicted speeded and non-speeded word reading performance. Exploratory hierarchical regressions showed that perceptual fluency for characters accounted for 5.3% and 9.6% variance in speeded and non-speeded reading respectively, in addition to age, non-verbal IQ, phonological awareness, morphological awareness, rapid automatized naming (RAN) and perceptual fluency for digits. The findings suggest that perceptual expertise with words plays an important role in Chinese reading performance in developmental dyslexia, and that perceptual training is a potential remediation direction.
Improvement of image quality and assessment of respiratory motion for hepatocellular carcinoma with portal vein tumor thrombosis using contrast-enhanced four-dimensional dual-energy computed tomography
Authors: Ohira Shingo , Kanayama Naoyuki , Wada Kentaro , Ikawa Toshiki , Hirata Takero , Kishi Noriko , Karino Tsukasa , Washio Hayate , Ueda Yoshihiro , Miyazaki Masayoshi , Koizumi Masahiko , Teshima Teruki
Published: January 2021

To assess the objective and subjective image quality, and respiratory motion of hepatocellular carcinoma with portal vein tumor thrombosis (PVTT) using the contrast-enhanced four-dimensional dual-energy computed tomography (CE-4D-DECT). For twelve patients, the virtual monochromatic image (VMI) derived from the CE-4D-DECT with the highest contrast to noise ratio (CNR) was determined as the optimal VMI (O-VMI). To assess the objective and subjective image quality, the CNR and five-point score of the O-VMI were compared to those of the standard VMI at 77 keV (S-VMI). The respiratory motion of the PVTT and diaphragm was measured based on the exhale and inhale phase images. The VMI at 60 keV yielded the highest CNR (4.8 ± 1.4) which was significantly higher (p = 0.02) than that in the S-VMI (3.8 ± 1.2). The overall image quality (4.0 ± 0.6 vs 3.1 ± 0.5) and tumor conspicuity (3.8 ± 0.8 vs 2.8 ± 0.6) of the O-VMI determined by three radiation oncologists was significantly higher (p < 0.01) than that of the S-VMI. The diaphragm motion in the L-R (3.3 ± 2.5 vs 1.2 ± 1.1 mm), A-P (6.7 ± 4.0 vs 1.6 ± 1.3mm) and 3D (8.8 ± 3.5 vs 13.1 ± 4.9 mm) directions were significantly larger (p < 0.05) compared to the tumor motion. The improvement of objective and subjective image quality was achieved in the O-VMI. Because the respiratory motion of the diaphragm was larger than that of the PVTT, we need to be pay attention for localizing target in radiotherapy.
Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews
Authors: Thabet Pierre , Joshi Anchal , MacDonald Erika , Hutton Brian , Cheng Wei , Stevens Adrienne , Kanji Salmaan
Published: January 2021

Objective

This overview of reviews aims to map and compare of objectives, methods, and findings of existing systematic reviews to develop a greater understanding of the information available about prolonged beta-lactam infusions in hospitalized patients with infection.

Design

Overview of systematic reviews.

Data sources

Medline, Embase, PROSPERO and the Cochrane Library were systematically searched from January, 1990 to June, 2019 using a peer reviewed search strategy. Grey literature was also searched for relevant reviews.

Eligibility criteria for selecting reviews

Systematic reviews were sought that compared two or more infusion strategies for intravenous beta-lactam antimicrobials and report clinical cure or mortality. Populations of included reviews were restricted to hospitalized patients with infection, without restrictions on age, infection type, or disease.

Data extraction and analysis

Abstract screening, data extraction, quality and risk of bias assessment were conducted by two independent reviewers. Overlap between reviews was assessed using a modified corrected covered area. Overview findings are reported in accordance with Cochrane’s recommendation for overview conduct. Clinical outcomes extracted included survival, clinical cure, treatment failure, microbiological cure, length of stay, adverse events, cost, and emergence of resistance.

Results

The search strategy identified 3327 unique citations from which 21 eligible reviews were included. Reviews varied by population, intervention and outcomes studied. Between reviews, overlap of primary studies was generally high, methodologic quality generally low and risk of bias variable. Nine of 14 reviews that quantitatively evaluated mortality and clinical cure identified a benefit with prolonged infusions of beta lactams when compared with intermittent infusions. Evidence of mortality and clinical cure benefit was greater among critically ill patients when compared to less sick patients and lower in randomized controlled trials when compared with observational studies.

Conclusions

Findings from our review demonstrate a consistent and reproducible lack of harm with prolonged infusions of beta-lactam antibiotics with variability in effect size and significance of benefits. Despite 21 systematic reviews addressing prolonged infusions of beta-lactams, this overview supports the continued need for a definitive systematic review given variability in populations, interventions and outcomes in the current systematic reviews. Subsequent systematic reviews should have more rigorous and transparent methods, only include RCTs and evaluate the proposed benefits found in various subgroup-analyses—i.e. high risk of mortality.

Trial registration

Prospero registry, CRD42019117118.
Risk stratification for advanced colorectal neoplasia based on the findings of the index and first surveillance colonoscopies
Authors: Honda Munenori , Naoe Hideaki , Gushima Ryosuke , Miyamoto Hideaki , Tateyama Masakuni , Sakurai Kouichi , Oda Yasushi , Murakami Yoshitaka , Tanaka Yasuhito
Published: January 2021

Risk stratification by index colonoscopy is well established for first surveillance endoscopy, but whether the previous two colonoscopies affect the subsequent advanced neoplasias has not been established. Therefore, the subsequent risk based on the findings of the index and first surveillance colonoscopies were investigated. This retrospective, cohort study was conducted in two clinics and included participants who had undergone two or more colonoscopies after index colonoscopy. High-risk was defined as advanced adenoma (≥ 1 cm, or tubulovillous or villous histology, or high-grade dysplasia). Based on the findings of the index and first surveillance colonoscopies, patients were classified into four categories: category A (both colonoscopy findings were normal), category B (no high-risk findings both times), category C (one time high-risk finding), and category D (high-risk findings both times). The incidence of subsequent advanced neoplasia was examined in each category. A total of 13,426 subjects were included and surveyed during the study periods. The subjects in category D had the highest risk of advanced neoplasia (27.4%, n = 32/117). The subjects in category A had the lowest risk (4.0%, n = 225/5,583). The hazard ratio for advanced neoplasia of category D compared to category A was 9.90 (95% Confidence interval 6.82–14.35, P<0.001). Classification based on the findings of index and first surveillance colonoscopies more effectively stratifies the risk of subsequent advanced neoplasia, resulting in more proper allocation of colonoscopy resources after two consecutive colonoscopies.
Morphometrics and processing yield of Cucumaria frondosa (Holothuroidea) from the St. Lawrence Estuary, Canada
Authors: Couillard Catherine M. , Maltais Domynick , Belley Rénald
Published: January 2021

Sea cucumber Cucumaria frondosa have highly variable whole body mass and length, and are usually sold to Asian markets as dried gutted body wall. Understanding the relation between size and yield of dry product is essential for resource conservation and for economic purposes. In this study, stock-specific mass and length recovery rates were estimated for C. frondosa captured by dredging or diving at various depths and seasons on the South shore of the St. Lawrence Estuary, along Gaspé Peninsula, and processed in a commercial plant. The processing yield in dry product mass per sea cucumber was more than 1.5 times larger for sea cucumbers collected at 26–47 m depth compared to those collected at 9–16 m depth. Within each strata, there was little variation in the processed body mass, seasonally or spatially. Recovery rates based on gutted mass for this stock (13.4─14.5%) varied little among depths and seasons, despite observed seasonal and bathymetric variation in reproductive status. In contrast, recovery rates based on whole body mass and length were highly variable both seasonally and spatially. Stress related to dredging or post-capture handling induced important variable body contraction and water content, leading to variation in body length, mass and shape of sea cucumbers having the same processed body mass. Gutted mass was the best metric to predict processed body mass and to estimate size whereas whole body length was the least reliable. New stock-specific information on variability of body mass, length, and recovery rates induced by capture, and on seasonal and bathymetric variation in reproductive status and processing yields will be used for the design of future stock assessment surveys, and for stock conservation.
The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes
Authors: Huang Shih-Chiang , Ng Kwai-Fong , Chang Ian Yi-Feng , Chang Chee-Jen , Chao Yi-Chun , Chang Shu-Chen , Chen Min-Chi , Yeh Ta-Sen , Chen Tse-Ching
Published: January 2021

The clinicopathological significance of altered SWI/SNF complex has not been well evaluated in gastric cancer (GC). We examined SMARCA2, SMARCA4, SMARCB1 and ARID1A expression by immunohistochemistry in 1224 surgically resected GCs with subtyping into Epstein-Barr virus (EBV), microsatellite instability (MSI) and non-EBV/MSI Lauren histotypes. SWI/SNF mutations were investigated using the GC dataset of the TCGA Pan-Cancer Atlas. Clinicopathological association was assessed by statistical analysis. There were 427 cases (35%) of SWI/SNF-attenuated GC, including 344 SMARCA2 (28%), 28 SMARCA4 (2%), 11 SMARCB1 (1%) and 197 ARID1A (16%) cases. Simultaneous alterations of multiple subunits were observed. Compared to SWI/SNF-retained cases, SWI/SNF-attenuated GC exhibited a significant predilection to older ages, EBV and MSI genotypes, higher lymphatic invasion and less hematogenous recurrence (P < 0.05). SWI/SNF attenuation was an independent risk factor for short overall survival (P = 0.001, hazard ratio 1.360, 95% confidence interval 1.138–1.625). The survival impact stemmed from SMARCA2-attenuated GCs in stage III and non-EBV/MSI diffuse/mixed subtypes (P = 0.019 and < 0.001, respectively). ARID1A-lost/heterogeneous GCs were more aggressive in the EBV genotype (P = 0.016). SMARCB1 or SMARCA4 loss was not restricted to rhabdoid/undifferentiated carcinoma. In the TCGA dataset, 223 of 434 GCs (52%) harbored deleterious SWI/SNF mutations, including ARID1A (27%), SMARCA2 (9%), ARID2 (9%), ARID1B (8%), PBRM1 (7%), and SMARCA4 (7%). SWI/SNF-mutated GCs displayed a favorable outcome owing to the high percentage with the MSI genotype. In conclusion, SWI/SNF-altered GCs are common and the clinicopathological significance is related to the genotype.
Characteristics of surface water quality and stable isotopes in Bamen Bay watershed, Hainan Province, China
Authors: Guo Julan , Yu Yilei , Wu Gaojie , Ma Muyuan
Published: January 2021

Bamen Bay is located at the intersection of the Wenjiao River and Wenchang River in Hainan Province (China), where mangroves have been facing a threat of water quality deterioration. Therefore, it is imperative to study the characteristics of the surface water quality on a watershed scale. Water samples were collected three times from 36 monitoring sites from 2015 to 2016. It was found that nitrate was the main inorganic nitrogen form and all the surface water types were alkaline. Meanwhile, aquaculture water had high content of nitrogen, total phosphorus, chlorophyll a (Chl.a), total organic carbon (TOC), and chemical oxygen demand (COD). Significant spatial and temporal variations were found for most parameters. However, stable isotopes of δD and δ18O indicated that river water mainly originated from atmospheric precipitation and experienced strong evaporation. The water chemistry and isotopes of the Bamen Bay, mangroves, and aquaculture water were initially affected by the mixing of fresh water and seawater, followed by evaporation. The river and reservoir water chemistry were mainly controlled by water–rock interactions and cation exchange as deduced from the ionic relationships and Gibbs plots. These interactions involved the dissolution of calcite-, bicarbonate-, carbonate-, and calcium-containing minerals. Oxidized environments (river, reservoir, and Bamen Bay) were conducive for nitrification, while anaerobic conditions (mangrove and aquaculture water) were beneficial to the reduced nitrogen forms.
A method for material decomposition and quantification with grating based phase CT
Authors: Deng Shiwo , Zhu Yining , Zhang Huitao , Wang Qian , Zhu Peiping , Zhang Kai , Zhang Peng
Published: January 2021

Material decomposition (MD) is an important application of computer tomography (CT). For phase contrast imaging, conventional MD methods are categorized into two types with respect to different operation sequences, i.e., “before” or “after” image reconstruction. Both categories come down to two-step methods, which have the problem of noise amplification. In this study, we incorporate both phase and absorption (PA) information into MD process, and correspondingly develop a simultaneous algebraic reconstruction technique (SART). The proposed method is referred to as phase & absorption material decomposition-SART (PAMD-SART). By iteratively solving an optimization problem, material composition and substance quantification are reconstructed directly from absorption and differential phase projections. Comparing with two-step MD, the proposed one-step method is superior in noise suppression and accurate decomposition. Numerical simulations and synchrotron radiation based experiments show that PAMD-SART outperforms the classical MD method (image-based and dual-energy CT iterative method), especially for the quantitative accuracy of material equivalent atomic number.
A randomized, open-label, parallel, multi-center Phase IV study to compare the efficacy and safety of atorvastatin 10 and 20 mg in high-risk Asian patients with hypercholesterolemia
Authors: Kim Ji Bak , Song Woo Hyuk , Park Jong Sung , Youn Tae-Jin , Park Yong Hyun , Kim Shin-Jae , Ahn Sung Gyun , Doh Joon-Hyung , Cho Yun-Hyeong , Kim Jin Won
Published: January 2021

Background

Although accumulating evidence suggests a more extensive reduction of low-density lipoprotein cholesterol (LDL-C), it is unclear whether a higher statin dose is more effective and cost-effective in the Asian population. This study compared the efficacy, safety, and cost-effectiveness of atorvastatin 20 and 10 mg in high-risk Asian patients with hypercholesterolemia.

Methods

A 12-week, open-label, parallel, multicenter, Phase IV randomized controlled trial was conducted at ten hospitals in the Republic of Korea between October 2017 and May 2019. High-risk patients with hypercholesterolemia, defined according to 2015 Korean guidelines for dyslipidemia management, were eligible to participate. We randomly assigned 250 patients at risk of atherosclerotic cardiovascular disease to receive 20 mg (n = 124) or 10 mg (n = 126) of atorvastatin. The primary endpoint was the difference in the mean percentage change in LDL-C levels from baseline after 12 weeks. Cost-effectiveness was measured as an exploratory endpoint.

Results

LDL-C levels were reduced more significantly by atorvastatin 20 mg than by 10 mg after 12 weeks (42.4% vs. 33.5%, p < 0.0001). Significantly more patients achieved target LDL-C levels (<100 mg/dL for high-risk patients, <70 mg/dL for very high-risk patients) with atorvastatin 20 mg than with 10 mg (40.3% vs. 25.6%, p < 0.05). Apolipoprotein B decreased significantly with atorvastatin 20mg versus 10 mg (−36.2% vs. −29.9%, p < 0.05). Lipid ratios also showed greater improvement with atorvastatin 20 mg than with 10 mg (total cholesterol/high-density lipoprotein cholesterol ratio, −33.3% vs. −29.4%, p < 0.05; apolipoprotein B/apolipoprotein A1 ratio, −36.7% vs. −31.4%, p < 0.05). Atorvastatin 20 mg was more cost-effective than atorvastatin 10 mg in terms of both the average and incremental cost-effectiveness ratios. Safety and tolerability of atorvastatin 20 mg were comparable to those of atorvastatin 10 mg.

Conclusion

In high-risk Asian patients with hypercholesterolemia, atorvastatin 20 mg was both efficacious in reducing LDL-C and cost-effective compared with atorvastatin 10 mg.
Age and extraversion differences in heart rate reactivity during working memory tasks
Authors: Pearman Ann , Neupert Shevaun D. , Ennis Gilda E.
Published: January 2021

Research and theory have shown a link between heart rate reactivity during cognitive testing and extraversion in younger adults; however, similar work has not been conducted with older adults. This study was designed to explore age and extraversion-related differences in within-person heart rate (HR) reactivity during two working memory tasks of varying difficulty using a multi-level modeling approach. Across 570 total within-person assessments of continuous HR monitoring, 28 younger adults (M = 19.76, SD = 1.15) and 29 older adults (M = 71.19, SD = 6.63) were administered two working memory tasks (backward digit span and n-back). There were no age differences in reactivity during the backward digit span. However, similar to previous findings, on the more difficult n-back task, younger adults low in extraversion showed a trend toward higher HR reactivity than young adults high in extraversion. Interestingly, the older adults showed the opposite pattern in that lower extraversion older adults were less reactive than the higher extraversion older adults who showed the steepest increase in HR. The HR increase of the older adults high in extraversion may be an indication of higher engagement in this more difficult task. Individual differences in extraversion need to be taken into account when administering working memory tasks in older adults.
The good, the bad and the ugly of lockdowns during Covid-19
Authors: Greyling Talita , Rossouw Stephanie , Adhikari Tamanna
Published: January 2021

Amidst the rapid global spread of Covid-19, many governments enforced country-wide lockdowns, with likely severe well-being consequences. In this regard, South Africa is an extreme case suffering from low levels of well-being, but at the same time enforcing very strict lockdown regulations. In this study, we analyse the causal effect of a lockdown and consequently, the determinants of happiness during the aforementioned. A difference-in-difference approach is used to make causal inferences on the lockdown effect on happiness, and an OLS estimation investigates the determinants of happiness after lockdown. The results show that the lockdown had a significant and negative impact on happiness. In analysing the determinants of happiness after lockdown, we found that stay-at-home orders have positively impacted happiness during this period. On the other hand, other lockdown regulations such as a ban on alcohol sales, a fear of becoming unemployed and a greater reliance on social media have negative effects, culminating in a net loss in happiness. Interestingly, Covid-19, proxied by new deaths per day, had an inverted U-shape relationship with happiness. Seemingly people were, at the onset of Covid-19 positive and optimistic about the low fatality rates and the high recovery rates. However, as the pandemic progressed, they became more concerned, and this relationship changed and became negative, with peoples' happiness decreasing as the number of new deaths increased.
Indirect questioning methods for sensitive survey questions: Modelling criminal behaviours among a prison population
Authors: Cobo Beatriz , Castillo Eva , López-Torrecillas Francisca , Rueda María del Mar
Published: January 2021

Information such as the prevalence and frequency of criminal behaviour is difficult to estimate using standard survey techniques because of the tendency of respondents to withhold or misrepresent information. Social desirability bias is a significant threat to the validity of self-reported data, especially when supplied by persons such as sexual offenders or those convicted of theft or substance abuse. The randomized response approach is an alternative to the standard interview method and offers great potential for researchers in the field of criminal justice. By means of a survey of 792 prison inmates, incorporating both indirect and direct response techniques, we investigate if the prison population also has problems recognizing their participation in criminal acts such as theft, illicit drug use, violence against property, reckless driving and arson. Our research findings suggest that self-reported criminal behaviour among a prison population is affected by social desirability bias and that the behaviour considered is significantly associated with the severity of obsessive-compulsive symptoms. The results also demonstrate the inadequacy of traditional, yet widely used, direct questioning methods, and the great potential for indirect questioning techniques to advance policy formation and evaluation in the field of criminal behaviour.
Developing a new individual earthquake resilience questionnaire: A reliability and validity test
Authors: Jiang Ning , Cheng Jingxia , Ni Zhihong , Ye Yansheng , Hu Rujun , Jiang Xiaolian
Published: January 2021

Earthquakes pose serious threats to the world. Good individual resilience can cope with disaster well, but there were few appropriate assessment tools. The purpose of this study was to develop a new individual earthquake resilience questionnaire and test its reliability and validity. First, we built the framework of the individual earthquake resilience questionnaire based on expert interviews. Then, we established the initial version of questionnaire and used the Delphi method and item selection to modify it by qualitative and quantitative methods. Finally, we built the final version of questionnaire (contained 4 dimensions and 17 items) and tested the reliability and validity. The Cronbach’s α values of the four dimensions were between 0.79 and 0.91, the split-half reliabilities were between 0.85 and 0.93, and the test-retest reliabilities were between 0.72 and 0.80. The item content validity indexes were between 0.87–1, and the average questionnaire content validity index was 0.94. The correlation coefficients between each item and dimension with the total questionnaire ranged from 0.79–0.90 and 0.66–0.79, respectively. We used exploratory factor analysis to identify four common factors with a cumulative variance contribution rate of 74.97%. The questionnaire is a valid and reliable tool to measure individual resilience in the context of earthquake disasters.
The association between physical complications following female genital cutting and the mental health of 12-year-old Gambian girls: A community-based cross-sectional study
Authors: Bendiksen Bothild , Heir Trond , Minteh Fabakary , Ziyada Mai Mahgoub , Kuye Rex A. , Lien Inger-Lise
Published: January 2021

Background

Female genital cutting (FGC) involve an acute physical trauma that hold a potential risk for immediate and long-term complications and mental health problems. The aim of this study was to examine the prediction of depressive symptoms and psychological distress by the immediate and current physical complications following FGC. Further, to examine whether the age at which 12-year-old Gambian girls had undergone the procedure affected mental health outcomes.

Method

This cross-sectional study recruited 134 12-year-old girls from 23 public primary schools in The Gambia. We used a structured clinical interview to assess mental health and life satisfaction, including the Short Mood and Feeling Questionnaire (SMFQ), the Symptom check list (SCL-5) and Cantril’s Ladder of Life Satisfaction. Each interview included questions about the cutting procedure, immediate- and current physical complications and the kind of help and care girls received following FGC.

Results

Depressive symptoms were associated with immediate physical health complications in a multivariate regression model [RR = 1.08 (1.03, 1.12), p = .001], and with present urogenital problems [RR = 1.19 (1.09, 1.31), p < .001]. The girls that received medical help following immediate complications had a lower risk for depressive symptoms [RR = .73 (.55, .98), p = .04]. Psychological distress was only associated with immediate complications [RR = 1.04 (1.01, 1.07), p = .004]. No significant differences in mental health outcomes were found between girls who underwent FGC before the age of four in comparison to girls who underwent FGC after the age of four.

Conclusion

Our findings indicate that the immediate and long-term complications following FGC have implications for psychological health. Only a minimal number of girls received medical care when needed, and the dissemination of health education seems crucial in order to prevent adverse long-term physical and psychological health consequences.
A novel procalcitonin-based score for detecting sepsis among critically ill patients
Authors: Tsui Tung-Lin , Huang Ya-Ting , Kan Wei-Chih , Huang Mao-Sheng , Lai Min-Yu , Ueng Kwo-Chang , Shiao Chih-Chung
Published: January 2021

Background

Procalcitonin (PCT) has been widely investigated as an infection biomarker. The study aimed to prove that serum PCT, combining with other relevant variables, has an even better sepsis-detecting ability in critically ill patients.

Methods

We conducted a retrospective cohort study in a regional teaching hospital enrolling eligible patients admitted to intensive care units (ICU) between July 1, 2016, and December 31, 2016, and followed them until March 31, 2017. The primary outcome measurement was the occurrence of sepsis. We used multivariate logistic regression analysis to determine the independent factors for sepsis and constructed a novel PCT-based score containing these factors. The area under the receiver operating characteristics curve (AUROC) was applied to evaluate sepsis-detecting abilities. Finally, we validated the score using a validation cohort.

Results

A total of 258 critically ill patients (70.9±16.3 years; 55.4% man) were enrolled in the derivation cohort and further subgrouped into the sepsis group (n = 115) and the non-sepsis group (n = 143). By using the multivariate logistic regression analysis, we disclosed five independent factors for detecting sepsis, namely, “serum PCT level,” “albumin level” and “neutrophil-lymphocyte ratio” at ICU admission, along with “diabetes mellitus,” and “with vasopressor.” We subsequently constructed a PCT-based score containing the five weighted factors. The PCT-based score performed well in detecting sepsis with the cut-points of 8 points (AUROC 0.80; 95% confidence interval (CI) 0.74–0.85; sensitivity 0.70; specificity 0.76), which was better than PCT alone, C-reactive protein and infection probability score. The findings were confirmed using an independent validation cohort (n = 72, 69.2±16.7 years, 62.5% men) (cut-point: 8 points; AUROC, 0.79; 95% CI 0.69–0.90; sensitivity 0.64; specificity 0.87).

Conclusions

We proposed a novel PCT-based score that performs better in detecting sepsis than serum PCT levels alone, C-reactive protein, and infection probability score.
On the quantification of local power densities in a new vibration bioreactor
Authors: Valentin David , Presas Alexandre , Roehr Charline , Mele Elisa , Biehl Christoph , Heiss Christian , Bosbach Wolfram A.
Published: January 2021

We investigate the power densities which are obtainable locally in a vibration bioreactor. These reactor systems are of great relevance for research about oncological or antibacterial therapies. Our focus lies on the local liquid pressure caused by resonance vibration in the fluid contained by the reactor’s petri dish. We use for the excitation one piezoelectric patch which offer advantages concerning controllability and reproducibility, when compared to ultrasound. The experimental work is extended by finite element analyses of bioreactor details. The peaks of the vibration response for water, sodium chloride (0.1N Standard solution), and McCoy’s 5A culture medium are in good alignment. Several natural frequencies can be observed. Local power density can reach multiple times the magnitude used in ultrasound studies. Based on the observed local power densities, we are planning future work for the exposure of cell cultures to mechanical vibration.
HFpEF without elevated right ventricular systolic pressure is a favorable prognostic indicator in patients with IPF requiring hospitalization for heart failure
Authors: Yamazaki Ryo , Nishiyama Osamu , Yoshikawa Kazuya , Saeki Sho , Sano Hiroyuki , Iwanaga Takashi , Tohda Yuji
Published: January 2021

Background

Some patients with idiopathic pulmonary fibrosis (IPF) must be hospitalized because of heart failure (HF), including HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF). The association between IPF and HF has not been clarified. We retrospectively investigated the clinical features and outcomes of patients with IPF who required nonelective hospitalization because of HF.

Methods

We examined data from IPF patients who required nonelective hospitalization for HF at the Kindai University Hospital from January 2008 to December 2018. We divided the patients into 3 groups: those with HFpEF without elevated right ventricular systolic pressure (RVSP), those with HFpEF and elevated RVSP, and those with HFrEF. The recurrence rates of HF after discharge and the 30- and 90-day mortality rates of the patients were evaluated.

Results

During the study period, 37 patients with IPF required hospitalization because of HF. Among the 34 patients included in the study, 17 (50.0%) were diagnosed with HFpEF without elevated RVSP, 11 (32.3%) with HFpEF and elevated RVSP, and 6 (17.6%) with HFrEF. Patients with HFrEF had significantly higher values for B-type natriuretic peptide (BNP) and left ventricular (LV) end-systolic and end-diastolic diameters than patients with the 2 types of HFpEF (BNP: P = 0.01 and P = 0.0004, LV end-systolic diameter: P <0.0001 and P <0.0001, and LV end-diastolic diameter: P = 0.01 and P = 0.0004, respectively). Notably, the difference between the LVEFs of the patients with 2 types of HFpEF was not significant. The patients with HFpEF without elevated RVSP had the lowest 30- and 90-day mortality rates (0%, P = 0.02 and 11.7%, P = 0.11, respectively).

Conclusions

Among patients with IPF, HFpEF without elevated RVSP was the most common type of HF that required hospitalization. Patients with HFpEF without elevated RVSP survived longer than the patients with the other 2 types of HF.
Epidemiology of injured patients in rural Uganda: A prospective trauma registry’s first 1000 days
Authors: Zheng Dennis J. , Sur Patrick J. , Ariokot Mary Goretty , Juillard Catherine , Ajiko Mary Margaret , Dicker Rochelle A.
Published: January 2021

Trauma is a leading cause of morbidity and mortality worldwide. Data characterizing the burden of injury in rural Uganda is limited. Hospital-based trauma registries are a critical tool in illustrating injury patterns and clinical outcomes. This study aims to characterize the traumatic injuries presenting to Soroti Regional Referral Hospital (SRRH) in order to identify opportunities for quality improvement and policy development. From October 2016 to July 2019, we prospectively captured data on injured patients using a locally designed, context-relevant trauma registry instrument. Information regarding patient demographics, injury characteristics, clinical information, and treatment outcomes were recorded. Descriptive, bivariate, and multivariate statistical analyses were conducted. A total of 4109 injured patients were treated during the study period. Median age was 26 years and 63% were male. Students (33%) and peasant farmers (31%) were the most affected occupations. Falls (36%) and road traffic injuries (RTIs, 35%) were the leading causes of injury. Nearly two-thirds of RTIs were motorcycle-related and only 16% involved a pedestrian. Over half (53%) of all patients had a fracture or a sprain. Suffering a burn or a head injury were significant predictors of mortality. The number of trauma patients enrolled in the study declined by five-fold when comparing the final six months and initial six months of the study. Implementation of a context-appropriate trauma registry in a resource-constrained setting is feasible. In rural Uganda, there is a significant need for injury prevention efforts to protect vulnerable populations such as children and women from trauma on roads and in the home. Orthopedic and neurosurgical care are important targets for the strengthening of health systems. The comprehensive data provided by a trauma registry will continue to inform such efforts and provide a way to monitor their progress moving forward.