bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Solid Waste-Based Composite Calcium Ferrite Flux and Its Application in Hot Metal Pre-Dephosphorization
Authors: Zhao Zheng , Feng Xiaoming , Zhang Yanling , Zhang Yao , Wu Yaoting
Published: February 2024

To enhance the slagging efficiency of the lime-based slag system during the pre-treatment stage of hot metal, a composite calcium ferrite flux based on aluminum industry solid waste was developed in this study. The melting characteristics of the flux and its application in the pre-treatment of hot metal were investigated. The results indicated that the main phases of the composite calcium ferrite were CaFe2O4, Ca2Fe2O5, and Ca2(Fe,Al)2O4. It exhibited high oxidation, high alkalinity, and a low melting point, thereby achieving excellent melting performance. Simulations of various dephosphorization fluxes in the pre-treatment of high-phosphorus hot metal, ordinary hot metal, and kilogram-scale dephosphorization experiment processes were conducted. Under the same experimental conditions, the composite calcium ferrite flux was able to achieve a dephosphorization rate of over 90% and a final phosphorus content of less than 0.02 wt% under high carbon content ([%C] = 3.2 wt%). In the application of hot metal pre-dephosphorization, this flux was able to achieve efficient melting and rapid slagging of lime at a lower temperature, and its slagging time was 50% faster than that of calcium ferrite flux. In addition, this flux enhanced the utilization efficiency of lime during the steelmaking process, effectively prevented the agglomeration of slag, and achieved efficient slag–metal separation. These characteristics were significantly better than the application effect of calcium ferrite flux. This flux has significant implications for the industrial application of deep dephosphorization in the pre-treatment stage of hot metal or the early stage of converter steelmaking.
Process Maps for Predicting Austenite Fraction (vol.%) in Medium-Mn Third-Generation Advanced High-Strength Steels
Authors: Mehrabi Azin , Zurob Hatem S. , McDermid Joseph R.
Published: February 2024

Process maps were developed using a combination of microstructural analysis and DICTRA-based modeling to predict the austenite vol.% as a function of the intercritical annealing parameters and starting microstructure. The maps revealed a strong dependence of the calculated austenite fraction (vol.%) on the Mn content (4–12 wt.%) and intercritical annealing temperatures (600 °C to 740 °C). The calculations were carried out for constant carbon, Al, and Si contents of 0.2 wt.%, 1.5 wt.%, and 1.0 wt.%, respectively. A modified empirical equation proposed by Koistinen and Marburger was employed to calculate the room-temperature retained austenite vol.% as a function of the intercritical annealing temperature, including the effect of the austenite composition. The process maps offer valuable insights for designing intercritical treatments of medium-Mn steels, aiding in the optimization of steel properties for automotive applications.
Formation of Natural Magnesium Silica Hydrate (M-S-H) and Magnesium Alumina Silica Hydrate (M-A-S-H) Cement
Authors: Austrheim Håkon , Hu Depan , Ulven Ole Ivar , Andersen Niels H.
Published: February 2024

Occurrences of natural magnesium alumina silicate hydrate (M-(A)-S-H) cement are present in Feragen and Leka, in eastern and western Trøndelag Norway, respectively. Both occurrences are in the subarctic climate zone and form in glacial till and moraine material deposited on ultramafic rock during the Weichselian glaciation. Weathering of serpentinized peridotite dissolves brucite and results in an alkaline fluid with a relatively high pH which subsequently reacts with the felsic minerals of the till (quartz, plagioclase, K-feldspar) to form a cement consisting of an amorphous material or a mixture of nanocrystalline Mg-rich phyllosilicates, including illite. The presence of plagioclase in the till results in the enrichment of alumina in the cement, i.e., forms M-A-S-H instead of the M-S-H cement. Dissolution of quartz results in numerous etch pits and negative quartz crystals filled with M-A-S-H cement. Where the quartz dissolution is faster than the cement precipitation, a honeycomb-like texture is formed. Compositionally, the cemented till (tillite) contains more MgO and has a higher loss of ignition than the till, suggesting that the cement is formed by a MgO fluid that previously reacted with the peridotite. The M-(A)-S-H cemented till represents a new type of duricrust, coined magsilcrete. The study of natural Mg cement provides information on peridotites as a Mg source for Mg cement and as a feedstock for CO2 sequestration.
An ImmunoFET Coupled with an Immunomagnetic Preconcentration Technique for the Sensitive EIS Detection of HF Biomarkers
Authors: Ben Halima Hamdi , Zine Nadia , Nemeir Imad Abrao , Pfeiffer Norman , Heuberger Albert , Bausells Joan , Elaissari Abdelhamid , Jaffrezic-Renault Nicole , Errachid Abdelhamid
Published: February 2024

We propose a new strategy using a sandwich approach for the detection of two HF biomarkers: tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10). For this purpose, magnetic nanoparticles (MNPs) (MNPs@aminodextran) were biofunctionalized with monoclonal antibodies (mAbs) using bis (sulfosuccinimidyl) suberate (BS3) as a cross-linker for the pre-concentration of two biomarkers (TNF-α and IL-10). In addition, our ISFETs were biofunctionalized with polyclonal antibodies (pAbs) (TNF-α and IL-10). The biorecognition between pAbs immobilized on the ISFET and the pre-concentrate antigen (Ag) on MNPs was monitored using electrochemical impedance spectroscopy (EIS). Our developed ImmunoFET showed a low detection limit (0.03 pg/mL) toward our target analyte when compared to previously published electrochemical immunosensors. It showed a higher sensitivity than for other HF biomarkers. Finally, the standard addition method was used to determine the unknown concentration in artificial saliva. The results matched with the expected values well.
Effectiveness of Switching CGRP Monoclonal Antibodies in Non-Responder Patients in the UAE: A Retrospective Study
Authors: Suliman Reem , Santos Vanessa , Al Qaisi Ibrahim , Aldaher Batool , Al Fardan Ahmed , Al Barrawy Hajir , Bader Yazan , Supena Jonna Lyn , Alejandro Kathrina , Alsaadi Taoufik
Published: February 2024

Calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) have shown promising effectiveness in migraine management compared to other preventative treatment options. Many questions remain regarding switching between antibody classes as a treatment option in patients with migraine headaches. This preliminary retrospective real-world study explored the treatment response of patients who switched between CGRP mAb classes due to lack of efficacy or poor tolerability. A total of 53 patients with migraine headache switched between three of the CGRP mAbs types due to lack of efficacy of the original prescribed CGRP mAbs, specifically eptinezumab, erenumab, and galcanezumab. Fremanezumab was not included due to unavailability in the UAE. Galcanezumab and eptinezumab target the CGRP ligand (CGRP/L), while erenumab targets CGRP receptors (CGRP/R). The analysis of efficacy demonstrated that some improvements were seen in both class switch cohorts (CGRP/R to CGRP/L and CGRP/L to CGRP/R). The safety of switching between CGRP classes was well observed, as any adverse events presented before the class switch did not lead to the discontinuation of treatment following the later switch. The findings of this study suggest that switching between different classes of CGRP mAbs is a potentially safe and clinically viable practice that may have some applications for those experiencing side effects on their current CGRP mAb or those witnessing suboptimal response.
Lactate Protects Intestinal Epithelial Barrier Function from Dextran Sulfate Sodium-Induced Damage by GPR81 Signaling
Authors: Li Xiaojing , Yao Zhijie , Qian Jin , Li Hongling , Li Haitao
Published: February 2024

The dysregulation of the intestinal epithelial barrier significantly contributes to the inflammatory progression of ulcerative colitis. Recent studies have indicated that lactate, produced by gut bacteria or derived from fermented foods, plays a key role in modulating inflammation via G-protein-coupled receptor 81 (GPR81). In this study, we aimed to investigate the potential role of GPR81 in the progression of colitis and to assess the impact of lactate/GPR81 signaling on intestinal epithelial barrier function. Our findings demonstrated a downregulation of GPR81 protein expression in patients with colitis. Functional verification experiments showed that Gpr81-deficient mice exhibited more severe damage to the intestinal epithelial barrier and increased susceptibility to DSS-induced colitis, characterized by exacerbated oxidative stress, elevated inflammatory cytokine secretion, and impaired expression of tight-junction proteins. Mechanistically, we found that lactate could suppress TNF-α-induced MMP-9 expression and prevent the disruption of tight-junction proteins by inhibiting NF-κB activation through GPR81 in vitro. Furthermore, our study showed that dietary lactate could preserve intestinal epithelial barrier function against DSS-induced damage in a GPR81-dependent manner in vivo. Collectively, these results underscore the crucial involvement of the lactate/GPR81 signaling pathway in maintaining intestinal epithelial barrier function, providing a potential therapeutic strategy for ulcerative colitis.
Impact of a Food Skills Course with a Teaching Kitchen on Dietary and Cooking Self-Efficacy and Behaviors among College Students
Authors: French Caitlin D. , Gomez-Lara Alexander , Hee Arianna , Shankar Akshara , Song Nayoung , Campos Monserrath , McCoin Mikelle , Matias Susana L.
Published: February 2024

College students may face barriers to eating healthy foods. Educational interventions providing practical knowledge and skills may help students to overcome financial barriers or other barriers to acquiring, preparing, and consuming healthy foods. We evaluated the association between participation in a semester-long food skills course with an interactive teaching kitchen and dietary and cooking self-efficacy and behaviors. Participants were recruited from course enrollees (intervention) and the general student population (comparison). We assessed differences in pre–post changes in the outcomes between groups using the propensity score weighting and mixed effects linear or Poisson regression. Course participation was associated with improved self-efficacy around cooking (group × time β-coefficient [SE]: 3.25 [0.57], p < 0.0001) and fruit (6.33 [1.19], p < 0.0001), vegetable (5.43 [1.42], p = 0.0002), and whole grain (5.83 [1.40], p < 0.0001) consumption. Course participants reported smaller pre–post decreases in vegetable consumption compared to non-participants (0.35 [0.16], p = 0.03), increased cooking frequency (0.22 [0.10], p = 0.03) and a decreased frequency of skipping meals (−0.47 [0.16], p = 0.003). There were no changes associated with the intervention in the consumption of fruit or whole grains, or in eating out frequency. Participation in a semester-long, personal food skills course with a teaching kitchen may improve self-efficacy, cooking, and vegetable consumption among college students.
A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy of Opuntia ficus-indica Prebiotic Supplementation in Subjects with Gut Dysbiosis
Authors: Mellai Marta , Allesina Marta , Edoardo Benedetto , Cascella Federica , Nobile Vincenzo , Spina Amelia , Amone Fabio , Zaccaria Vincenzo , Insolia Violetta , Perri Anna , Lofaro Danilo , Puoci Francesco
Published: February 2024

Gut dysbiosis refers to an imbalance in gut microbiota composition and function. Opuntia ficus-indica extract has been shown to modulate gut microbiota by improving SCFA production in vivo and gastrointestinal discomfort (GD) in humans. The aim of this study was to demonstrate the efficacy of OdiliaTM on gastrointestinal health by changing the microbial diversity of species involved in inflammation, immunity, oxidation, and the brain–gut–muscle axis. A randomized, double-blind clinical trial was conducted in 80 adults with gut dysbiosis. The intervention consisted of a 300 mg daily intake of OdiliaTM (n = 40) or maltodextrin as a placebo (n = 40), administered for 8 weeks. Intervention effect was evaluated using 16S metagenomics and GIQLI/GSAS scores at baseline, at 4 and 8 weeks. Eight weeks of OdiliaTM supplementation positively modulates gut microbiota composition with a significant reduction in the Firmicutes to Bacteroidetes ratio (p = 0.0012). Relative abundances of beneficial bacteria (Bacteroides and Clostridium_XIVa) were significantly increased (p < 0.001), in contrast to a significant reduction in pro-inflammatory bacteria (p < 0.001). Accordingly, GIQLI and GSAS scores revealed successful improvement in GD. OdiliaTM may represent an effective and well-tolerated treatment in subjects with gut dysbiosis.
Nutritional and Physiological Properties of Thymbra spicata: In Vitro Study Using Fecal Fermentation and Intestinal Integrity Models
Authors: Khalil Mohamad , Piccapane Francesca , Vacca Mirco , Celano Giuseppe , Mahdi Laura , Perniola Valeria , Apa Carmen Aurora , Annunziato Alessandro , Iacobellis Ilaria , Procino Giuseppe , Calasso Maria , De Angelis Maria , Caroppo Rosa , Portincasa Piero
Published: February 2024

(Poly)phenolic-rich Mediterranean plants such as Thymbra spicata have been associated with several health-promoting effects. The nutritional value, as well as physiological interaction of T. spicata with the gastrointestinal tract, has not been investigated before. The nutritional composition of T. spicata leaves was here characterized by standard analytical methods. T. spicata leaves were subjected to ethanolic extraction, simulated gastrointestinal digestion, and anaerobic microbial gut fermentation. Phenols/flavonoid contents and radical scavenging activity were assessed by colorimetric methods. The volatile organic compounds (VOCs) were detected by gas chromatography coupled with mass spectrometry. The effect on intestinal integrity was evaluated using a Caco-2 monolayers mounted in a Ussing chamber. T. spicata contains a high amount of fiber (12.3%) and unsaturated fatty acids (76% of total fat). A positive change in VOCs including short-chain fatty acids was observed without significant change in viable microbe. T. spicata and carvacrol (main phenolic compound) enhanced ionic currents in a concentration-dependent manner without compromising the Caco-2 monolayer’s integrity. These effects were partially lost upon simulated digestion and completely abolished after colonic fermentation in line with polyphenols and carvacrol content. Conclusion: T. spicata represents a promising nutrient for the modulation of gut microbiota and the gut barrier. Further studies must better define its mechanisms of action.
Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives
Authors: Noor Eddin Ahmed , Alfuwais Mohammed , Noor Eddin Reena , Alkattan Khaled , Yaqinuddin Ahmed
Published: February 2024

Amyotrophic Lateral Sclerosis (ALS) is a highly fatal neurodegenerative disorder characterized by the progressive wasting and paralysis of voluntary muscle. Despite extensive research, the etiology of ALS remains elusive, and effective treatment options are limited. However, recent evidence implicates gut dysbiosis and gut–brain axis (GBA) dysfunction in ALS pathogenesis. Alterations to the composition and diversity of microbial communities within the gut flora have been consistently observed in ALS patients. These changes are often correlated with disease progression and patient outcome, suggesting that GBA modulation may have therapeutic potential. Indeed, targeting the gut microbiota has been shown to be neuroprotective in several animal models, alleviating motor symptoms and mitigating disease progression. However, the translation of these findings to human patients is challenging due to the complexity of ALS pathology and the varying diversity of gut microbiota. This review comprehensively summarizes the current literature on ALS-related gut dysbiosis, focusing on the implications of GBA dysfunction. It delineates three main mechanisms by which dysbiosis contributes to ALS pathology: compromised intestinal barrier integrity, metabolic dysfunction, and immune dysregulation. It also examines preclinical evidence on the therapeutic potential of gut-microbiota-modulating agents (categorized as prebiotics, probiotics, and postbiotics) in ALS.
Prevalence and Intensity of Sarcocystis spp. Infections in Alpine Chamois (Rupicapra r. rupicapra) in Germany
Authors: Rehbein Steffen , Visser Martin
Published: February 2024

Chamois are mountain ungulates (Artiodactyla: Caprinae) which inhabit several medium- and high-altitude mountain ranges from southern Europe to the Near East. The first findings of Sarcocystis cysts in the musculature of chamois were reported in the 1970s. However, only limited work on the epidemiology of sarcocystosis and the identification of the species of Sarcocystis in chamois has been carried out in the past. The present study aimed to provide, for the first time, data on the prevalence and intensity of Sarcocystis spp. Infection in native Alpine chamois using a histology examination of heart and/or diaphragm tissue samples collected from 216 chamois (40 kids [<1 year] and 176 chamois ranging up to 18 years of age). Sarcocysts were detected in either the heart or diaphragm of 167/216 chamois (77.3%), with 131 of 183 heart samples and 127 of 215 diaphragm samples testing sarcocyst-positive. Of the 181 chamois with both heart and diaphragm samples available (34 kids and 147 older animals), sarcocysts were detected in the heart and/or diaphragm of 142 animals, translating to an overall 78.5% prevalence of Sarcocystis spp. infection (95%CI 72.5–84.4%). Sarcocysts were more frequently recorded in the heart vs. diaphragm (72.4% vs. 56.4%; p = 0.0021), and diaphragm positivity was associated with heart positivity (p = 0.0001). The sarcocyst prevalence (heart and/or diaphragm) was significantly (p < 0.001) lower in the kids than in the older chamois (27.1% vs. 88.6%, respectively); however, it did not differ between the sexes, regardless of the chamois’ age (p > 0.3). The intensity of infection was generally low (<10 sarcocysts per cm2 muscle cut) in both heart-positive and diaphragm-positive animals (94.7% and 93.7%, respectively). The heart tissue yielded higher sarcocyst counts than the diaphragm tissue (p < 0.001). Both the heart and diaphragm sarcocyst counts were significantly (p < 0.001) lower in the kids than in the older chamois. Sarcocystis spp. infection was demonstrated to be prevalent in chamois in Germany, but its intensity is apparently low. Further studies are desired to identify the species of Sarcocystis parasitizing the chamois using both phenotypic and molecular characteristics.
Measuring and Modeling of Melt Viscosity for Drug Polymer Mixtures
Authors: Kimmel Vincent , Ercolin Enrico , Zimmer Robin , Yörük Muhammet , Winck Judith , Thommes Markus
Published: February 2024

Melt viscosity is an essential property in pharmaceutical processes such as mixing, extrusion, fused deposition modeling, and melt coating. Measuring and modeling of the melt viscosity for drug/polymer mixtures is essential for optimization of the manufacturing process. In this work, the melt viscosity of nine formulations containing the drug substances acetaminophen, itraconazole, and griseofulvin, as well as the pharmaceutical polymers Eudragit EPO, Soluplus, and Plasdone S-630, were analyzed with a rotational and oscillatory rheometer. The shear rate, temperature, and drug fraction were varied systematically to investigate their influence on viscosity. The results for the pure polymers showed typical shear-thinning behavior and are fundamental for modeling with the Carreau and Arrhenius approaches. The investigations of the viscosity of the drug/polymer mixtures resulted in a plasticizing or a filler effect, depending on the type of drug and the phase behavior. A drug shift factor was proposed to model the change in viscosity as a function of the drug fraction. On this basis, a universal model to describe the melt viscosity of drug/polymer mixtures was developed, considering shear rate, temperature, and drug fraction.
Exploring the Effects of Process Parameters during W/O/W Emulsion Preparation and Supercritical Fluid Extraction on the Protein Encapsulation and Release Properties of PLGA Microspheres
Authors: Park Heejun
Published: February 2024

In this study, protein-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared via supercritical fluid extraction of emulsion (SFEE) technology. To understand the correlation between process parameters and the main quality characteristics of PLGA microspheres, a comprehensive prior study on the influence of process variables on encapsulation efficiency (EE), initial drug burst release (IBR), morphology, surface property, and particle size distribution (PSD) was conducted within a wide process condition range of each unit process step, from the double-emulsion preparation step to the extraction step. Bovine serum albumin (BSA), a high-molecular weight-protein that is difficult to control the IBR and EE of PLGA microspheres with, was used as a model material. As double-emulsion manufacturing process parameters, the primary (W/O) and secondary emulsion (W/O/W) homogenization speed and secondary emulsification time were evaluated. In addition, the effect of the SFEE process parameters, including the pressure (70–160 bar), temperature (35–65 °C), stirring rate (50–1000 rpm), and flow rate of supercritical carbon dioxide, SC-CO2 (1–40 mL/min), on PLGA microsphere quality properties were also evaluated. An increase in the homogenization speed of the primary emulsion resulted in an increase in EE and a decrease in IBR. In contrast, increasing the secondary emulsification speed resulted in a decrease in EE and an increase in IBR along with a decrease in microsphere size. The insufficient secondary emulsification time resulted in excessive increases in particle size, and excessive durations resulted in decreased EE and increased IBR. Increasing the temperature and pressure of SFEE resulted in an overall increase in particle size, a decrease in EE, and an increase in IBR. It was observed that, at low stirring rates or SC-CO2 flow rates, there was an increase in particle size and SPAN value, while the EE decreased. Overall, when the EE of the prepared microspheres is low, a higher proportion of drugs is distributed on the external surface of the microspheres, resulting in a larger IBR. In conclusion, this study contributes to the scientific understanding of the influence of SFEE process variables on PLGA microspheres.
Drug–Drug Interactions in Patients with Acute Respiratory Distress Syndrome
Authors: Bischof Thorsten , Schaller Christoph , Buchtele Nina , Staudinger Thomas , Ullrich Roman , Kraft Felix , Andersson Marine L. , Jilma Bernd , Schoergenhofer Christian
Published: February 2024

Acute respiratory distress syndrome (ARDS) is a potential life-threatening, heterogenous, inflammatory lung disease. There are no data available on potential drug–drug interactions (pDDIs) in critically ill patients with ARDS. This study analyzed pDDIs in this specific cohort and aimed to investigate possible associations of coronavirus disease 2019 (COVID-19) as an underlying cause of ARDS and treatment with extracorporeal membrane oxygenation (ECMO) with the occurrence of pDDIs. This retrospective study included patients ≥18 years of age diagnosed with ARDS between January 2010 and September 2021. The Janusmed database was used for the identification of pDDIs. A total of 2694 pDDIs were identified in 189 patients with a median treatment duration of 22 days. These included 323 (12%) clinically relevant drug combinations that are best avoided, corresponding to a median rate of 0.05 per day. There was no difference in the number of pDDIs between COVID-19- and non-COVID-19-associated ARDS. In patients treated with ECMO, the rate of the most severely graded pDDIs per day was significantly higher compared with those who did not require ECMO. PDDIs occur frequently in patients with ARDS. On average, each patient may encounter at least one clinically relevant drug combination that should be avoided during their intensive care unit stay.
The Influence of Residual Stresses on the Curve Shape—Describing Interface Behavior in “Polymer–Fiber” Systems
Authors: Gorbatkina Yulia A. , Ivanova-Mumzhieva Viktoria G. , Alexeeva Olga V. , Vyatkina Mariya A.
Published: February 2024

The pull-out method was used to study the adhesive strength τ of “fiber–thermoset” systems with wide variations in area. Studied binders were based on resins that had different chemical natures (epoxy, epoxy phenol, orthophthalic, polyphenylsiloxane, and phenol–formaldehyde). Shear adhesive strength was determined for systems with two fiber types (glass and steel fibers). It was shown that strength τ depended on scale (area). Formation of τ occurred during the curing process and the system’s subsequent cooling to the measurement temperature T. It was found that interface strength depended on measurement temperature across a wide temperature range that covered the highly elastic and the glassy state of the adhesive. The influence of residual stresses τres, acting at the “binder–fiber” interface, on the nature of the curves describing the dependence of the adhesive strength on the studied factor was experimentally shown. A qualitative explanation of the observed regularities is proposed.
Effect of the Formation of Hydrophilic and Hydrophobic–Hydrophilic Associates on the Behavior of Copolymers of N-Vinylpyrrolidone with Methyl Acrylate in Aqueous Solutions
Authors: Shaikhutdinov Ramazan , Mun Grigoriy , Kopishev Eldar , Bakirov Akhat , Kabdushev Sherniyaz , Baipakbaeva Saltanat , Suleimenov Ibragim
Published: February 2024

It has been shown that there exist conditions under which thermosensitive copolymers of N-vinylpyrrolidone with methyl acrylate form hydrophobic–hydrophilic associations, which are unstable dynamic meshes, the bonds in which are continuously broken and created again, and the nature of the formation of such meshes depends significantly on the proportion of the hydrophobic component in the copolymer. It is shown that the interaction of the above copolymers with polyacrylic acid results in the formation of not only classical interpolymer complexes, but also hydrophilic interpolymer associates, which also represent unstable networks existing in a dynamic mode. In such meshes, the molecules of the above copolymers serve as a kind of cross-agent connecting the polyacid molecules. There are also conditions under which such meshes acquire a complex structure, since unstable bonds between macromolecular tangles of both the same and different types take part in their formation. It is shown that the transition from the formation of interpolymer complexes to the formation of hydrophilic interpolymer associates can occur, among other things, due to changes in the acidity or concentration of low-molecular salt in solution.
Transient Response of Macroscopic Deformation of Magnetoactive Elastomeric Cylinders in Uniform Magnetic Fields
Authors: Glavan Gašper , Belyaeva Inna A. , Shamonin Mikhail
Published: February 2024

Significant deformations of bodies made from compliant magnetoactive elastomers (MAE) in magnetic fields make these materials promising for applications in magnetically controlled actuators for soft robotics. Reported experimental research in this context was devoted to the behaviour in the quasi-static magnetic field, but the transient dynamics are of great practical importance. This paper presents an experimental study of the transient response of apparent longitudinal and transverse strains of a family of isotropic and anisotropic MAE cylinders with six different aspect ratios in time-varying uniform magnetic fields. The time dependence of the magnetic field has a trapezoidal form, where the rate of both legs is varied between 52 and 757 kA/(s·m) and the maximum magnetic field takes three values between 153 and 505 kA/m. It is proposed to introduce four characteristic times: two for the delay of the transient response during increasing and decreasing magnetic field, as well as two for rise and fall times. To facilitate the comparison between different magnetic field rates, these characteristic times are further normalized on the rise time of the magnetic field ramp. The dependence of the normalized characteristic times on the aspect ratio, the magnetic field slew rate, maximum magnetic field values, initial internal structure (isotropic versus anisotropic specimens) and weight fraction of the soft-magnetic filler are obtained and discussed in detail. The normalized magnetostrictive hysteresis loop is introduced, and used to explain why the normalized delay times vary with changing experimental parameters.
Mucoadhesive Polymeric Polyologels Designed for the Treatment of Periodontal and Related Diseases of the Oral Cavity
Authors: Andrews Gavin P. , Laverty Thomas , Jones David S.
Published: February 2024

The study objective was to design and characterise herein unreported polyologels composed of a range of diol and triol solvents and polyvinyl methyl ether-co-maleic acid (PVM/MA) and, determine their potential suitability for the treatment of periodontal and related diseases in the oral cavity using suitable in vitro methodologies. Polyologel flow and viscoelastic properties were controlled by the choice of solvent and the concentration of polymer. At equivalent polymer concentrations, polyologels prepared with glycerol (a triol) exhibited the greatest elasticity and resistance to deformation. Within the diol solvents (PEG 400, pentane 1,5-diol, propane 1,2-diol, propane 1,3-diol, and ethylene glycol), PEG 400 polyologels possessed the greatest elasticity and resistance to deformation, suggesting the importance of distance of separation between the diol groups. Using Raman spectroscopy bond formation between the polymer carbonyl group and the diol hydroxyl groups was observed. Polyologel mucoadhesion was influenced by viscoelasticity; maximum mucoadhesion was shown by glycerol polyologels at the highest polymer concentration (20% w/w). Similarly, the choice of solvent and concentration of PVM/MA affected the release of tetracycline from the polyologels. The controlled release of tetracycline for at least 10 h was observed for several polyologels, which, in combination with their excellent mucoadhesion and flow properties, offer possibilities for the clinical use of these systems to treat diseases within the oral cavity.
The Influence of Selected Fillers on the Functional Properties of Polycarbonate Dedicated to 3D Printing Applications
Authors: Bulanda Katarzyna , Oleksy Mariusz , Oliwa Rafał
Published: February 2024

Additive manufacturing is still the fastest-developing technology in the modern world. Three-dimensional printing has become popular due to the method’s numerous advantages, such as its short time and low cost, compared to conventional methods such as injection molding. Therefore, the demand for new materials and material systems that will be characterized by the desired functional properties is clearly growing. As part of this work, work was carried out on the development and preparation of new polymer composites dedicated to 3D printing applications, especially in FDM/FFF/MEM technologies. The influence of the content and amount of fillers, such as silica modified with alumina (S) and bentonite modified with a quaternary ammonium salt (B), on the functional properties of a commercially available fiber made of traditional plastic, such as polycarbonate, obtained in the form of a filament (PCF), was determined. It was found that the addition of B significantly increased the fluidity of the polymer, the introduction of a filler in the amount of 1.5% allowed to obtain a result that was 6% higher compared to PCF (16.8 g/10 min), while the amount of 3% was 20% higher. The obtained mass melt flow rate (MFR) results were confirmed by determining the viscosity of the produced polymer composites. Satisfactory results of mechanical properties were obtained, including the following: it was found that the introduced modified fillers increased the elasticity of the material. The introduction of modified silica resulted in a reduction in Young’s modulus by 10.02% at the content of 0.5% S and at 1% S by 8.64% compared to the polymer. The introduced modified filler S significantly increased the thermostability of polycarbonate (T5% equal to 449 °C) by 23 °C for PCF/0.5% S and 14 °C for PCF/1% S, respectively. The SEM and WAXS results confirmed the appropriate dispersion of the fillers in the polymer matrix, which indicates well-selected conditions for the homogenization process of the components and the subsequent production of samples. Detailed characterization of the influence of selected fillers on the functional properties of the polymer matrix-polycarbonate allowed for an increase in the range of polymer composites and their use in rapid prototyping technologies, as well as supplementing the literature on databases regarding the characteristics of the obtained materials.
Chemically Engineered Titanium Oxide Interconnecting Layer for Multijunction Polymer Solar Cells
Authors: Kim Geunjin , Back Hyungcheol , Kong Jaemin , Naseer Laiba , Jeong Jiwon , Son Jaehyoung , Lee Jongjin , Kang Sung-Oong , Lee Kwanghee
Published: February 2024

We report chemically tunable n-type titanium oxides using ethanolamine as a nitrogen dopant source. As the amount of ethanolamine added to the titanium oxide precursor during synthesis increases, the Fermi level of the resulting titanium oxides (ethanolamine-incorporated titanium oxides) significantly changes from −4.9 eV to −4.3 eV, and their free charge carrier densities are enhanced by two orders of magnitudes, reaching up to 5 × 1018 cm−3. Unexpectedly, a basic ethanolamine reinforces not only the n-type properties of titanium oxides, but also their basicity, which facilitates acid–base ionic junctions in contact with acidic materials. The enhanced charge carrier density and basicity of the chemically tuned titanium oxides enable multi-junction solar cells to have interconnecting junctions consisting of basic n-type titanium oxides and acidic p-type PEDOT:PSS to gain high open-circuit voltages of 1.44 V and 2.25 V from tandem and triple architectures, respectively.
Limited from the Outside: Francisco Suárez and the External Limits of Political Power
Authors: Barroso Leonor Durão
Published: February 2024

Francisco Suárez has been interpreted both as a champion of absolute power and as an advocate of popular sovereignty. Although not taking a position in this debate, this paper seeks to understand whether Suárez’s political thought provides theoretical ground to advance the notion of limited government. It focuses specifically on the question of whether there are, in Suárez’s work, external limits to the power of rulers at home. The answer is considered by regarding two elements, which we argue contribute to such a limitation. First, the paper considers how the ius gentium hinders the possibility of an all-powerful government at home; then, it focuses on how the hierarchical ordering of the spiritual and temporal spheres limit the scope of the ruler of the latter. It is argued that both elements provide some ground for limiting the extent of power by rulers in their communities.
Study on Carbon Emissions from an Urban Water System Based on a Life Cycle Assessment: A Case Study of a Typical Multi-Water County in China’s River Network Plain
Authors: Gui Zihan , Qi Heshuai , Wang Shiwu
Published: February 2024

Revealing the inherent relationship between urban water systems and carbon emissions has important theoretical and practical significance for promoting “water conservation and carbon reduction” in cities. This study utilizes the 2021 social water cycle statistical data of Yiwu City to quantify the carbon emissions of urban water systems. It analyzes the “water–carbon” related characteristics and carbon emission intensities under different water sources and stages and explores the carbon reduction potential of urban water systems under different scenarios. The results show that the operational phase is the main contributor to the carbon emissions of the urban water system in the research area, accounting for approximately 86% of the total carbon emissions. Over the entire process, the carbon emissions from the water supply and drainage stages are the largest, accounting for 39% and 31% of the total carbon emissions, respectively. In terms of carbon emission intensity, the carbon footprint of the water cycling process using reclaimed water as the water source is higher than that of high-quality water and conventional water sources. This is primarily due to the significantly higher carbon emission intensity in the reclaimed water phase compared with the other phases. In terms of influencing factors, the differences in the “water–carbon” correlation characteristics of different links in the water system in the research area are mainly affected by changes in urban water consumption, water treatment methods and processes, and other related factors. For the coordinated development of “water conservation and carbon reduction” in urban areas, future efforts should focus on improving the reuse rate of reclaimed water in urban life and industry, reducing the leakage rate of water distribution networks, and enhancing water treatment processes. These measures aim to increase water efficiency in urban water systems and reduce carbon emissions.
A Fuzzy-AHP Multi-Criteria Decision-Making Approach for a Sustainable Supply Chain of Rice Farming Stakeholders in Edu-Patigi LGA, Kwara State, Nigeria
Authors: Bello Adenike Oluyemi , Mbhele Thokozani Patmond
Published: February 2024

The adoption of sustainable practices in decision making in supply chain operations among rice farmers and other stakeholders in Nigeria could be an effective tool to drive food security. The triple bottom line identifies the environmental, economic, and social dimensions of sustainability. These could be harnessed to improve the supply chain of locally produced rice, ultimately improving food security in the region. This paper adopts a quantitative method that uses 21 criteria from the three sustainability dimensions to measure rice stakeholders’ decision-making activities against sustainable rice practices (SRPs) using a Fuzzy Analytical Hierarchy Process multi-criteria decision-making approach. The findings reveal that decisions with regard to water usage, supplier diversity, and a safe working environment were ranked high, while government intervention, quality assurance, transparency, and power usage ranked low. This implies that improved performance of other stakeholders across the rice value chain such as the government and extension officers would enhance productivity and drive food security in the region.
Impact of Structural and Non-Structural Measures on the Risk of Flash Floods in Arid and Semi-Arid Regions: A Case Study of the Gash River, Kassala, Eastern Sudan
Authors: Shuka Kamal Abdelrahim Mohamed , Wang Ke , Abubakar Ghali Abdullahi , Xu Tianyue
Published: February 2024

Sediment precipitation in riverbeds influences the effectiveness of structural and non-structural measures for flash flood mitigation and increases the potential for flooding. This study aimed to disclose the effectiveness of the implemented measures for flood risk mitigation in Kassala town, eastern Sudan. We employed remote sensing (RS) and GIS techniques to determine the change in the Gash River riverbed, the morphology, and the leveling of both the eastern and western sides of the river. Flood model simulation and a 3D path profile were generated using the digital elevation model (DEM) with a data resolution of 12.5 m from the ALOS BILSAR satellite. The main purpose of this study is to extract the layer of elevation of the riverbed on both the western and eastern banks and to determine the variations and their relationship to flood occurrence and mitigation. The construction of dikes and spurs near Kassala town has led to sediment precipitation, causing the riverbed to rise. The results show that it is now 1.5 m above the eastern Kassala town level, with a steep slope of 2 m/km, and the cross-section area at Kassala bridge has shrunk, which indicates that the bridge body will partially impede the river’s high discharge and increase the potential for flood risk in the study area. The eastern part of Kassala town has a higher likelihood of flooding than the western side. This study suggests redesigning structural measures like widening the Gash River, extending Kassala bridge for normal water flow, strengthening early warning systems, and implementing soil conservation activities for normal water flow.
What Is a Resilient Smart City? Blue–Green Infrastructure as a Strategic Feature of Smart Urban Form: Empirical Evidence with a Particular Focus on the Songdo IBD and Aspern Seestadt in Vienna
Authors: Gorgol Natalia K.
Published: February 2024

This study concerns the correlation of a smart city as an idea with urban form, with a particular focus on blue–green infrastructure. It aims to bridge the research gap on the physical structure of a smart city. It attempts to answer the following questions: (1) are there any patterns or rules in how a smart city’s urbanscape should be shaped? (2) Can green and recreational spaces contribute to a smart city’s smartness? If so, can a smart city be more resilient? To answer these questions, the author proposes the framework of a ‘smart urban form’ and a five-goal checklist to evaluate the blue–green infrastructure of a smart city. This checklist tool is based on the following five goals: morphology, ecology and environmental protection, accessibility, multifunctionality and activities, and identity and aesthetics, with specific factors for each goal. The paper presents a test of the tool on two existing smart city urban structures: the Songdo IBD, South Korea, and Aspern Seestadt, Vienna, Austria. This research is based on a combination of mixed methods: analysis of the literature, a multiple-case study, and observation. A correlation between the resilience of a smart city and its urban form, with an emphasis on blue–green infrastructure, was found.
Resilience Capability of Indigenous People Affected by Small-Scale Gold Mining Activities: A Prevention Approach
Authors: Mamola Randi , Widagso Kisnu , Herdiansyah Herdis
Published: February 2024

This research addresses three main review points related to the harmful practices of artisanal and small-scale gold mining and the appropriateness of prevention approaches to resilience for local residents’ environments. First, the focus is on cases of illegal mining exploitation in North Rarowatu and Lantari Jaya, with emphasis on the aspects of disaster risk management and prevention approaches in construction areas. Second, focus is given to the abundance of gold grains in the mining area, which attracts the author to utilize a dynamic system approach to explore whether a progressive restructuring exists for avoiding casualties in the mining area. Third, the precautionary accuracy of the security forces and the government are given focus to emphasize the prohibition of mercury absorption as a mining method. This research utilizes a system dynamics methodology to investigate the review of preventive approaches for maintaining the resilience of local communities and the determinants of small-scale gold mining activities by considering other empirical testing models. This study finds that a 30–50% increase in gold production significantly results in hydrological pollution due to mercury content, increased worker deaths, and unending damage to resident ecosystems, with minimal preventive capabilities in the pre-illegal artisanal and small-scale gold mining period. Moreover, this study offers an input and output prevention approach to controlling the number of illegal gold miners while protecting the environmental resilience of local residents.
How Does the Low-Carbon City Pilot Policy Affect Enterprises’ Green Innovation? Empirical Evidence from the Context of China’s Digital Economy Development
Authors: Song Yinghao , Bian Zhaian , Ma Nianzhai , Tu Wei
Published: February 2024

The integrated development of green innovation and digital economy is crucial for addressing global climate change, promoting the application and popularization of digital technologies in the green sector, and achieving efficient, intelligent, and sustainable economic development and lifestyles. Using panel data from China’s listed enterprises from 2003 to 2021, this study examines the impacts of environmental regulations on green innovation in the low-carbon city pilot policy (LCCPP) context, which serves as a quasi-natural experiment in the digital economy. The results show that LCCPP effectively enhances enterprises’ green innovation by increasing enterprises’ environmental and research and development investments, and boosting digital transformation. Heterogeneity analysis reveals that the promotion effect of LCCPP on green innovation is highly pronounced for enterprises in the eastern region, for those with low financial constraints, and for technology-intensive enterprises. This effect is closely and positively correlated with the digital economy level in the regions where the enterprises are located. This study provides new empirical evidence for the relationship between environmental regulations and enterprises’ green innovation and discusses policy support for addressing global climate change challenges through environmental regulations in the digital economy context, thereby promoting global sustainable development.
Intention to Transition: Natural Rubber Smallholders Navigating the Risks of Farming
Authors: Suriansyah  , Nurliza  , Dolorosa Eva , Rosyadi  , Suswati Denah
Published: February 2024

This study delves into the decision-making dynamics of Indonesian rubber farmers amidst a significant agricultural transition from traditional rubber farming to diverse agricultural practices. Anchored in the Theory of Planned Behavior (TPB) and Protection Motivation Theory (PMT), this research elucidates the multifaceted interplay of the psychological, social, and environmental factors influencing these transitions. Utilizing Structural Equation Modeling (SEM) to analyze data from structured interviews and questionnaires, this study presents a nuanced understanding of how a higher awareness of the risks associated with rubber farming negatively impacts farmers’ attitudes, adherence to social norms, and perceived behavioral control. The findings reveal that while heightened risk understanding and threat appraisal motivate a shift towards alternative agricultural practices, factors like community norms and perceived behavioral control significantly deter this transition. This research contributes a novel integration of the TPB and PMT in the context of agricultural decision making, offering pivotal insights for stakeholders and policymakers aiming to foster sustainable agricultural practices and navigate the complex socio-economic landscape of Indonesia’s agricultural sector.