bluuebunny/crossref_metadata_2025 huggingface dataset:
Prospects for the use of sulfur-containing pteridines in toxic liver damage
Authors: Lohvinenko N. , Shvets V. , Berest G. , Nosulenko I. , Voskoboinik O. , Severina H. , Okovytyy S. , Kovalenko S.
Published: August 2024

The presented material describes the results of the purposeful search for the novel hepatoprotective agents among synthetic sulfur-containing pteridines. The studied compounds were obtained using previously described synthetic procedures. SwissADME and ProTox-II services, as well as a docking study were used to predict the compounds` pharmacokinetics, drug-likeness and toxicity. The effects of sulfur-containing pteridines on lipid peroxidation in vitro and GSH/GSSG levels in vivo were studied for evaluation of their hepatoprotective potential. In silico procedures allowed us to exclude the compounds with inappropriate ADME parameters and high predicted toxicity. Molecular docking of the obtained compounds towards the active site of CYP-enzyme allowed us to clarify the specifics of ligand-enzyme interactions and predict cytochrome-inhibiting activity of the studied agents. The antioxidant activity of the studied compounds was evaluated in vitro using the linoleic acid peroxidation model. It has been found that sulfur-containing pteridines inhibit the peroxidation of linoleic acid. The structure – antioxidant activity relationships were evaluated and discussed as well. Additionally, it has been estimated that antioxidant properties of the studied pteridines directly correlate with their hydrophilicity and number of functional groups with exchangeable proton in molecules. In vivo studies showed that some of the studied sulfur-containing pteridines reduced severity of the hepatotoxic effects caused by the administration of carbon tetrachloride. (3-(7-Hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydropteridin-6-yl)propanoyl)alanine has been identified as the most active hepatoprotective agent. The above mentioned compound significantly increases the content of GSH and decreases the level of GSSG compared with non-treated experimental pathology, which reliably affirms its hepatoprotective activity. The hepatoprotective activity of the studied compounds is likely associated with their ability to increase the level of GSH, inhibit lipid peroxidation and decrease prooxidant compounds levels. The obtained results attest the reasonability of further search for hepatoprotective agents among sulfur-containing pteridine derivatives.
The value of computer reconstruction in the treatment of intra-articular fractures of the distal part of the humerus
Authors: Kovalov Olexandr , Pelypenko Olexandr , Kononenko Serhii , Pavlenko Svitlana , Malyk Serghii
Published: August 2024

The aim of the work was to study the role of computer reconstruction and additive technologies in the planning of surgical treatment of intra-articular fractures of the distal part of the humerus in the early post-traumatic period.
Materials and methods: the results of treatment of 44 patients with fractures of the distal part of the humerus aged from 22 to 65 years were studied.
All patients underwent MSCT in the preoperative period. In 45.5 % (20) cases, in order to increase the effectiveness of preoperative planning, simulation osteosynthesis was performed on an individual printed model of the damaged bone.
After completion of preoperative planning, all patients underwent osseous metallo-osteosynthesis in the first week after receiving the injury. In order to assess the effectiveness of the application of visualization techniques, a survey of the operating team was carried out regarding the informativeness of the conducted instrumental studies.
Results. The average duration of surgical intervention among patients in the clinical group with standard preoperative planning was 105.9 ± 9.15 minutes. The average results of the survey of the surgical team after the surgical interventions in the specified clinical group were 21.2 ± 2.8 points.
The average duration of surgery among patients of the second clinical group, whose preoperative planning included not only the assessment of MSCT results of the damaged segment, but also simulated osteosynthesis with the selection and application of optimal metal fixators, was 54.6 ± 7.14 minutes. The average results of the survey of the surgical team were 31.2 ± 1.7 points.
Conclusions. The use of a combination of visualization technologies and 3D printing allows to reduce the time the patient spends in the operating room and increase the effectiveness of preoperative planning.
Performing simulated osteosynthesis in the preoperative period allows you to develop an individual technique of repositioning bone fragments and use the optimal standard size of the cortical metal fixator with the distribution of the most favourable compression points of bone fragments
Development of a patient health monitoring system based on a service-oriented architecture using artificial intelligence
Authors: Boloban Oleh , Pysmennyi Ihor , Kyslyi Roman , Kyriusha Bogdan
Published: August 2024

The object of the study is a patient health monitoring system that uses service-oriented architecture (SOA) and artificial intelligence (AI) to integrate and analyze medical data. Such a system integrates data from a variety of sources, including medical devices, health apps, electronic health records, and wearables and physiological performance recorders, providing a comprehensive approach to health monitoring. Thanks to SOA, the system is able to process large arrays of data in real time, providing the opportunity to quickly process and analyze them. This allows medical professionals to get a comprehensive picture of patients' health, taking into account both long-term trends and real-time indicators.
One of the most challenging areas is ensuring effective integration and processing of disparate data from various medical devices and applications for accurate diagnosis and prognosis of diseases. It is also important to create a system that is easily scalable and can be adapted to the needs of different medical facilities and various monitoring systems.
As a result of the research, it is concluded that the use of SOA allows creating flexible and scalable systems capable of integrating a wide range of medical devices and applications. The use of AI in these systems makes it possible to automatically detect deviations in health indicators, recognize pathologies in the early stages and predict the possible development of diseases. This is due to the fact that the proposed architecture has a number of features, in particular, the ability to collect, process and analyze large volumes of medical data in real time. Artificial intelligence algorithms provide high accuracy of diagnosis and forecasting thanks to the ability to quickly process complex data and find hidden patterns. Thanks to this, it is possible to obtain accurate and reliable indicators of the state of health of patients. Compared to similar known systems, it provides such advantages as increased efficiency of medical care, reduced risk of complications, early detection of diseases and a personalized approach to patient treatment, as well as the concentration of all data in one system.
Development of fuzzified neural network for enterprise bankruptcy risk estimation
Authors: Sinkovskyi Artem , Shulakov Volodymyr
Published: August 2024

The object of this study is the assessment of the level of enterprise bankruptcy risk. It is a critical component in assessing the financial condition of an enterprise, and also serves as an indicator that allows the management team to reduce potential risks and develop their own strategies to strengthen the financial condition of the enterprise. One of the most challenging aspects of bankruptcy forecasting is the complex financial situations of bankrupt companies. By accurately predicting the risk of bankruptcy, businesses can take preventive measures to mitigate financial difficulties and ensure long-term sustainability. Previous methods, such as Altman's Z-score, are not accurate enough, as presented in the study. The paper investigates a modern approach to bankruptcy prediction based on a neural network with complex neural elements, namely neural arithmetic logic units (NALUs) and a custom phasing layer. This layer can process complex raw numerical values, such as financial indicators relevant to the analysis of a company's bankruptcy. Compared to Altman's Z-score, the developed method demonstrates a better F1 score in bankruptcy classification (48 %). On the raw data, the neural network demonstrates an improvement in the F1 score by about 40 % compared to the classical multilayer perceptron (MLP) with linear layers and nonlinear activation functions. A modern replacement for ReLU called Mish was used, which achieves better generalization. It was also assumed that the addition of new neural elements, which provide the neural network with arithmetic capabilities, contributes to the performance of processing non-normalized input data. This work highlights the importance of using advanced neural network architectures to improve the accuracy and reliability of forecasting in financial risk assessment. Using the parameters presented in the study, managers of enterprises will be able to more accurately assess the risk of bankruptcy.
Creation of an identifier database for the ammonia synthesis computer control system
Authors: Babichenko Anatolii , Krasnikov Igor , Babichenko Juliya , Dzevochko Oleksandr , Lysachenko Ihor
Published: August 2024

The object of research is the control system of the synthesis department of the large-tonnage ammonia production unit of the AM-1360 series. An analysis of the functioning conditions of the synthesis department was carried out. The significant influence of the content of inerts in the synthesis cycle on the energy efficiency of ammonia production is shown, the optimal value of which depends both on the accepted level of prices for energy carriers and on the method of using purge gases. The need to create a computer-integrated control technology to optimize the use of purge gases is established. The function of the identifier of such a control technology is defined, namely, continuous refinement based on current information about the state of the main sections of the synthesis department, such as the synthesis column, primary and secondary condensation. The operation of these stations takes place in the conditions of seasonal and daily changes in the heat load, which causes parametric uncertainty of such parameters of the connection of the mathematical model as the concentration of ammonia in the circulating gas at the outlet of the stations listed above. Numerical assessment of these uncertainties according to the results of analytical studies for such technological objects is most often performed using stochastic approximation methods. Let’s note that the significant inertia of the objects of the synthesis department under certain conditions makes it impossible to adapt the parameter to its actual value.
An algorithmic base has been created for the formation of an information array of the identifier of the computer-integrated control technology of the ammonia synthesis department, which ensures the separation of transient modes under conditions of uncertainty and allows to perform the task of identifying processes in the synthesis column, in the primary and secondary condensation units. The proposed algorithm allows to perform convergence in the department both on the general and on the component material balances. The algorithm is implemented in the MatLab application program package and tested by means of simulation based on experimental data of industrial operation of AM-1360 series ammonia synthesis units.
Assessment of the opportunities of demolition waste using as a building material of the future in Ukraine
Authors: Bielohrad Anastasiia
Published: August 2024

The object of research is the potential of secondary use of waste from the destruction of buildings and structures, which were formed as a result of the military aggression of the Russian Federation on the territory of Ukraine. For Ukraine, the issue of demolition waste is critical at the level of environmental safety and ensuring the demand for building materials for the reclamation of Ukraine according to the principles of the circular economy. To date, there are no official methods that would allow to determine the exact amount of destruction and the quality of the material formed, which complicates the development of mechanisms for its utilization in production. The key industry considered during the research for disposal of demolition waste is the industry of construction materials production.
In the course of research, it was determined that most of the generated waste is waste from the destruction of buildings and structures made of precast concrete, however, considering that these wastes are generated by the action of explosions from shells. It is very difficult to ensure their compliance with the requirements of current standards due to the inclusion that such waste can contain. Therefore, the problem considered by this study is the determination of the nature of waste from the destruction of buildings and structures, their physical, mechanical and chemical characteristics, in the context of the final applications of products based on them.
The results of the study showed that when reproducing the concrete mix for tared concrete for civil purposes, which do not have high requirements for stability in aggressive operating conditions, when replacing natural aggregate crushed to a fraction of 5 to 20 mm, the requirements for concrete strength are achieved in the level of C40/50 strength class. But the rheological characteristics deteriorate due to the high absorption of water from the concrete mixture by the studied material. Research has shown that for further use in the production of ready-mixed concrete and precast concrete products, it is necessary to prepare demolition waste with a wide particle size distribution and low dust content. This can ensure a high level of recycling and meet the demand for concrete in the reconstruction of Ukraine. The fine aggregate from the demolition waste crushing process can be considered as secondary cementitious material for cement production.
Analysis of refrigerants used in supermarket commercial equipment and the potential for increasing energy efficiency and reducing environmental impact
Authors: Polukhin Volodymyr , Yakovleva Olga
Published: August 2024

Refrigerants used in the commercial equipment of supermarkets are the object of the research. The Montreal Protocol calls for a complete phase-out of hydrochlorofluorocarbons (HCFCs) by 2030, and the Kigali Amendment regulates the use of hydrofluorocarbons (HFCs) from 2019. Developed countries began phasing out HFC use in 2019, while developing countries plan to freeze HFC consumption from 2024. These global efforts are aimed at reducing the depletion of the ozone layer and combating climate change. The number of supermarkets in the world varies greatly: in Europe they number from 110 thousand to 115 thousand, and in China – from 65 thousand to 70 thousand, which reflects various needs in refrigeration equipment. Stringent environmental regulations are forcing the commercial refrigeration sector to remain globally competitive. Modernization of supermarkets using natural refrigerants is important for solving emerging challenges. The results of the study show significant improvements in energy efficiency ratio (EER) and coefficient of performance (COP) when using a mixture of hydrocarbons (R290: 85 %, R600a: 15 %) compared to traditional refrigerants R404a, R449a and R502. Specifically, at the evaporation temperature of Tevap=–10 °C, EER increased by 38–44 % and COP by 26–31 % compared to R404a and R449a, respectively. At Tevap=–25 °C, EER increased by 17–34 % and COP by 2–22 % compared to R404a and R449a. Additionally, compared to R502, the hydrocarbon blend showed a 38–44 % increase in EER and 28–31 % COP at Tevap=–10 °C, and a 17–34 % increase in EER and 5–22 % COP at Tevap=–25 °C. These results highlight the advantages of the hydrocarbon mixture at different evaporation temperatures, indicating its potential to improve energy efficiency in refrigeration applications. The obtained data suggest the possibility of a wider application of the mixture of hydrocarbons in commercial refrigeration plants, offering both improved performance and compliance with safety regulations.
Modeling the design of marketing research of the brands’ social responsibility
Authors: Vasylyshyna Liubov , Yahelska Kateryna
Published: August 2024

The object of the research is the brands’ social responsibility. The process of marketing research on the brands’ social responsibility is considered. The phenomenon of brands’ social responsibility has been studied and the need for a detailed study of its directions has been proven. The influence of socially responsible actions of brands on increasing their level of awareness and loyalty is substantiated. Trends in the development of brands’ social responsibility at the current stage have been determined. It has been established that the brands’ social responsibility is related to environmental initiatives, social justice, ethical responsibility, sponsorship and charity, economic responsibility, and the implementation of innovations. The directions of brands’ social responsibility are characterized on the example of companies Johnson&Johnson, Google and Coca-Cola, which are primarily related to environmental initiatives. The most popular areas of brands’ social responsibility have been established by means of a survey, which gives grounds for asserting the priority of environmental initiatives, sponsorship and charity. Attention is focused on the role of marketing research in the brands’ social responsibility. The main types of marketing research design are characterized – exploratory, evaluative and reproducible. A structural model of marketing research on the brands’ social responsibility is proposed. This model takes into account all stages of the process of researching the brands’ social responsibility – from the conditions for the implementation of social initiatives to the formation of the strategy of brands’ social responsibility. The practical value of the proposed model of marketing research on the brands’ social responsibility will allow to study social initiatives more deeply and in detail and choose the most priority ones. This, in turn, will create prerequisites for increasing brand loyalty and forming an effective communication strategy.
Determination of the impact of innovative technologies in the system of strategic management of corporate social responsibility
Authors: Poberezhna Zarinа , Trukhan Oleksandr , Bileush Arkadii , Kniaziev Anton
Published: August 2024

The object of research is the process of using innovative technologies in the system of strategic management of social responsibility of enterprises. The main problem solved during the research was the need for a more effective integration of the principles of social responsibility in the business strategy, which will help enterprises to adapt to the global challenges and demands of modern society. The study of new technological approaches in this area allowed to identify the most effective tools for increasing transparency, responsibility and sustainable development of companies. As a result of the conducted research, the content of the concept «innovative technologies in the system of strategic management of social responsibility of enterprises» was clarified, which is proposed to be understood as a modern approach to the integration of technological innovations into strategic management, aimed at improving the social indicators of the enterprise. These technologies are found to include a wide range of tools such as Big Data, Artificial Intelligence (AI), Internet of Things (IoT), Blockchain, and others that help businesses effectively implement and monitor social programs and initiatives. It is substantiated that the use of innovative digital technologies in the system of strategic management of social responsibility of enterprises opens wide opportunities and generates significant advantages. Namely, increasing transparency and openness; optimization of resources and costs; increasing internal efficiency; strengthening of reputation and brand; automation of enterprise processes; innovativeness and competitive advantages; stimulating innovation. A model for determining the relationship between the level of profitability of enterprises by type: large, medium, and small enterprises and by the number of employees and their labor costs is proposed, which allows to establish the required number of employees for each type of enterprise. This enables the enterprise to function effectively, reducing labor costs, but not reducing the positive impact on supporting the social sector of the population, creating jobs and remaining a socially responsible enterprise. The possibility of using the latest digital technologies in the social responsibility management of enterprises is summarized.
Association Between Proton Pump Inhibitor Use and the Severity of Periodontal Disease and Peri-Implantitis: A Systematic Review
Authors: Vedaei Amirhossein , Salimi Yasaman , Iranshahi Zahra , Sadighnia Negar , Taheri Hamed , Eyvani Mahsa , Bagherianlemraski Mobina , Taheri Zahra , Khanmohammadi Mohammad Mahdi , Bina Simin , Kavousi Arghavan , Bagheri-Hosseini Sara , Mosaddad Seyed Ali , Azimi Nozhan , Valipour Rubina , Atarodi Seyed Mahmoud , Deravi Niloofar
Published: August 2024

This systematic review investigates the probable effect of proton pump inhibitor (PPI) use on the severity of periodontal disease and peri-implantitis and implant survival. We conducted a literature search in PubMed, Scopus, and Cochrane Central Library up to April 2024. Two review authors independently screened the title and abstracts and then the full texts of retrieved studies. Observational and clinical trial studies that assessed the association between PPI use and periodontal disease severity and peri-implantitis or implant survival were included. Data extraction from the included studies was done by 2 reviewers independently. Of 940 studies initially retrieved from online searching, 7 met the inclusion criteria. Three studies examined periodontitis, whereas 4 focused on peri-implantitis and implant longevity. On the contrary, evidence regarding the impact of PPI use on peri-implantitis and implant survival is conflicting. Therefore, more well-designed randomized controlled trials are warranted to come to a definite conclusion. Because PPIs alter the gut microbiome and affect bone, plus that the pathogenesis and etiology of periodontal disease are affected by bacteria within the periodontal pocket, it is hypothesized that they may affect periodontal pathogenesis.
Determinantes Sociais de Saúde e sua Influência na Homogeneidade da Cobertura Vacinal na Paraíba
Authors: Cunha Nairmara Soares Pimentel , Pamplona Ysabely de Aguiar Pontes , Bernardes Luzana Mackevicius , Olinda Ricardo Alves de , Braga Alfésio Luís Ferreira , Oliveira Elda de Oliveira , Martins Lourdes Conceição , Fahrat Sylvia Costa Lima
Published: August 2024

A Homogeneidade da Cobertura Vacinal (HCV) é um importante indicador de saúde pública para a identificação de bolsões de suscetíveis. Analisar a distribuição espacial da HCV nos municípios paraibanos e relacionar com os determinantes sociais de saúde. Trata-se de um estudo com delineamento ecológico do tipo misto, onde os dados usados são secundários e de domínio público para o período de 2016 a 2020. Para atingir o objetivo do estudo utilizou-se técnicas de análise espacial. A HCV mostrou-se heterogênea em todo o Estado com formação de bolsões de susceptíveis. Cobertura de pré-natal (OR=0,572; IC95%: 0,409-0,799; p<0,001) associou-se positivamente com HCV adequada. Proporção de indivíduos com rede de água e esgoto inadequada (OR=1,345; IC95%: 1,007-1,796; p=0,045) e proporção de mulheres como chefes de família (OR=1,512; IC95%: 1,082-2,113; p=0,015) associam-se inversamente com a HCV adequada. Nosso estudo, destaca a importância da identificação de áreas geográficas com indivíduos susceptíveis e dos fatores que interferem individualmente e em conjunto com a HCV, pois possibilita ações direcionadas e eficientes, assegurando a resolutividade.
Atuação do(a) psicólogo(a) na atenção básica: uma revisão integrativa
Authors: Aparecida Teixeira Karine , Brum Leitão Iagor , Iglesias Alexandra
Published: August 2024

Este estudo realizou uma revisão integrativa da literatura nacional sobre o papel do(a) psicólogo(a) na Atenção Básica (AB), abrangendo artigos publicados entre 2008 e 2021 nas bases de dados PePSIC, BVS e SciELO. Aplicados os critérios de inclusão e exclusão, chegou-se a um banco final de 11 artigos. Os resultados indicaram uma diversificação de práticas do(as) psicólogos(as) na AB: participação em grupos de saúde e saúde mental, elaboração de projeto terapêutico singular, visitas domiciliares, ações intersetoriais, atividades terapêuticas de lazer, caminhadas da saúde, palestras, trabalhos manuais, ações de redução de dano, entre outras. No entanto, a atuação ainda tem se mostrado predominantemente individualista e curativista, persistindo o enfoque em atendimentos individuais. Os principais desafios reportados incluíram o desinteresse dos(as) psicólogos(as) em participar de formações sobre a AB e o desconhecimento acerca do papel da psicologia nesse âmbito da saúde. A revisão aponta que a ruptura com o modelo prioritariamente individual-curativista constitui caminho para uma atuação da Psicologia mais condizente com os princípios e diretrizes do SUS, começando nas graduações, ainda permeadas por esse modelo e que tendem a enfatizar as psicoterapias como principais práticas em saúde. Assim, a revisão aponta para a necessidade dos(as) psicólogos(as) em afirmarem uma postura cada vez mais condizente com a perspectiva da AB, mesmo que haja um longo caminho a ser percorrido para romper com o modelo predominante.
Elos entre a precarização laboral e a saúde mental do trabalhador
Authors: Germano Canuto Sales Laís Maria , Carvalho de Sousa Ana Laís , Barbosa Dedê Dária Maria , Alves de Sousa Janne Izabel , Guimarães de Carvalho Renata , Araújo Lopes Vieira Camilla
Published: August 2024

O presente trabalho objetiva realizar uma revisão integrativa da literatura acerca da temática da precarização do trabalho e suas possíveis correlações/reflexos para a saúde mental dos trabalhadores. Para tanto, foi realizada busca nas plataformas BVS, SciElo e Periódicos Capes, entre os meses de dezembro de 2022 e março de 2023, com os seguintes descritores: precarização do trabalho e saúde mental do trabalhador. A partir dos resultados foram analisados 45 trabalhos, nos quais se identificaram aspectos que fomentam a precarização do trabalho, a saber: a crise do capital, a nova morfologia do trabalho, a ascensão da ideologia neoliberal, além da recente crise sanitária provocada pela pandemia de Covid-19. Diante desse cenário emergiram os contextos de precarização do trabalho e saúde mental dos trabalhadores de saúde, educação, dentre outras categorias profissionais. Os apontamentos demonstram que a precarização pode repercutir negativamente nas relações de trabalho, acarretando desgaste físico e mental, impactando na produtividade, favorecendo absenteísmo e afastamentos, bem como adoecimentos de ordem física e psíquica. Nessa perspectiva, embora tenham sido identificadas correlações entre precarização do trabalho e saúde mental dos trabalhadores, constata-se a necessidade de maior aprofundamento em estudos que possam expressar um maior diagnóstico de nexo causal entre a precarização do trabalho e a saúde mental dos trabalhadores.
A queixa e a demanda no serviço-escola de psicologia da Universidade Feevale: uma perspectiva psicanalítica
Authors: Stedile Sabina Maria , Rosario Gustavo , Finger Mariáh , Heinen Luiz Gustavo , Reichert Figueiredo Júlia , Blankenheim Thaís
Published: August 2024

Os Serviços-escola de Psicologia constituem-se como espaços de aprendizado prático dos(as) alunos(as) de final de graduação e possibilitam atendimento a comunidades menos favorecidas. Neste estudo pretendemos identificar a queixa inicial pela qual as pessoas buscaram atendimento no Serviço Escola de Psicologia da Universidade Feevale nos últimos três anos e analisar se existiu uma transformação dessa queixa em demanda de tratamento ao longo dos atendimentos. De maneira geral, na clínica psicanalítica, é possível compreender a queixa como a primeira forma de expressão do sofrimento do paciente, enquanto a demanda apresenta algo mais profundo e inconsciente. Trata-se de uma pesquisa documental de abordagem qualitativa e a coleta de dados foi realizada através de documentos arquivados no Serviço-escola. Para a análise dos dados utilizamos a análise de conteúdo (Bardin, 2011). Foram construídas duas categorias iniciais de análise - queixa inicial e transformação da queixa em demanda - e três subcategorias durante o processo de leitura e análise de dados: conflito interpessoal, perdas e lutos e manifestações de ansiedade. A principal queixa das pessoas dessa amostra estava relacionada a perdas e lutos, o que pode estar associado ao momento situado em meio a pandemia da covid-19. Sobre a transformação da queixa, pudemos observar que, em alguns casos, a queixa vai se desdobrando, através da fala e da escuta, modificando o posicionamento do sujeito em relação ao seu sofrimento e, noutros, a queixa permanece inalterada ao longo do processo, no entanto, não sem causar efeitos terapêuticos. A pesquisa em psicanálise não parte da busca de um saber inquestionável, pois é através do remanejamento e constante movimento que a prática psicanalítica e a pesquisa podem avançar, promovendo um aprofundamento contínuo na compreensão dos fenômenos psíquicos.
Implicações do despertar da puberdade em condições congênitas
Authors: Zanotti Susane , Rodrigues Lilian
Published: August 2024

O objetivo deste artigo é analisar o despertar da puberdade para pessoas com condições congênitas, nas quais as transformações do corpo diferem do desenvolvimento biologicamente esperado. Trata-se de uma pesquisa qualitativa, descritiva e analítica, com entrevistas clínicas com pessoas com diagnóstico de Diferenças do Desenvolvimento do Sexo (DDS) atendidas no ambulatório de genética de um hospital geral. A análise do material, com o aporte da psicanálise de Freud e Lacan sobre o despertar da puberdade resultou nos eixos-temáticos: comparações e estranhamentos; entre o homem, a mulher e nenhum; o despertar do sonho da “normalidade” e, contornos ao real de gerar filhos e do preconceito. Os resultados apontam que embora o desenvolvimento de caracteres sexuais secundários seja atípico ou ausente, os participantes 'não escapam ilesos da puberdade'.  O despertar da puberdade nessas situações revelaram o peso das normas biológicas e seu valor na relação com o outro e a resposta sintomática de cada um ao enigma do sexo.
Pesquisa participante na escola: vivências de uma professora de História com os indígenas
Authors: Cezar Tavares Freire Jaqueline , Luisa Texeira de Menezes Ana , Rosane Silveira Souza Fátima , Soares Zanette Taíse
Published: August 2024

Na pesquisa participante realizada com uma escola de rede pública destacamos as contribuições de um processo colaborativo intercultural, com abordagens sobre os povos indígenas do Brasil, principalmente os Kaingang e os Guarani.  Destacamos o diário de campo da professora e um longo processo de extensão e de pesquisa vivenciados, durante um período de 2018 a 2024, no qual analisamos os possíveis caminhos na busca por um ensino transversal e intercultural com os indígenas. São contribuições para a efetivação da Lei 11.645/2008 que determina a obrigatoriedade do ensino da História e da Cultura indígena na educação básica. Uma das questões problematizadoras desta pesquisa foi: como podemos construir um caminho para uma educação ameríndia na escola? Como olhar para nossas raízes indígenas e repensar nossas práticas interculturais enquanto docentes? Ficou evidenciado a importância da extensão e da pesquisa com indígenas, no processo formativo das professoras para pensar ações e estudos na escola, o destaque da disciplina e da professora de História como impulsionadora para reelaborar os sentidos de uma educação ameríndia que atravessa outras disciplinas como ciências, literatura e português. Verificamos que a participação de professoras e estudantes em vivências nas aldeias indígenas provocam uma mudança de pensamento em torno da educação, modificando comportamentos e potencializando ações educativas denominadas como ameríndias, pois inclui a terra, o rio, o fogo, o ar e todos os ensinamentos que os indígenas nos fazem aprender sobre o sentido da vida na educação.
Cas9 Protein Purification Protocol v2
Authors: Huang Shu
Published: August 2024

This protocol outlines the steps for purifying Cas9 protein, essential for the preparation of RNP complexes used in CRISPR-Cas9 editing processes.
Optimal positioning and distribution of magnetorheological damper
Authors:   Department of Civil Engineering, Karunya Institute of Technology and Sciences, Coimbatore, India, K Chandan , C Daniel ,   Department of Civil Engineering, Hindustan Institute of Technology and Science, Chennai, India, P Anuroop ,   Department of Civil Engineering, Karunya Institute of Technology and Sciences, Coimbatore, India, Sharma S. Vivekananda ,   Department of Civil Engineering, Karunya Institute of Technology and Sciences, Coimbatore, India, E Arunraj ,   Department of Civil Engineering, Karunya Institute of Technology and Sciences, Coimbatore, India, G Hemalatha ,   Department of Civil Engineering, Karunya Institute of Technology and Sciences, Coimbatore, India
Published: August 2024

During seismic events, devices are used to disperse energy in buildings, reducing structural damage and preventing collapse. One such device is the magnetically polarizable particle damper, consisting of a hydraulic cylinder filled with magnetically responsive particles in fluid. Recent research optimized damper placement and distribution using detailed mathematical modeling and mode shapes covering over 95% of the building's mass. Researchers identified critical damper positions by correlating these models with maximum force functions in the equations of motion. The study proposed a positioning strategy to reduce costs associated with damper installation in typical building practices. The number of dampers required varied with applied loads: 20kN, 30kN, 90kN, and up to 200kN. For instance, under 20kN and 30kN loads, optimal distribution included assigning 8 dampers to the ground, first, second floors, decreasing to 4 on floors three and four, and 2 on the fifth floor, totaling 14 and 20 dampers, respectively. Optimization values for these loads were calculated at 17.71. Dealing with a 90kN load required 44 dampers, distributed as 8 on lower levels, 4 on the third floor, and 8 each on floors four and five. Remarkably, while 20kN and 30kN damper counts reduced, 24 were added for 90kN, yielding an optimization score of 45.84. For a 200kN load, 17 dampers were strategically allocated, with specific placements adjusted per floor, achieving an efficiency score of 49.616. This underscores the effectiveness of the chosen damper arrangement in bolstering structural resilience against seismic forces.
Comportamientos de riesgo y factores asociados en motociclistas de una ciudad de Argentina
Authors:   Universidad Nacional de Mar del Plata, Tosi Jeremías David , Minjolou Natalia Alejandra ,   Universidad Nacional de Mar del Plata, Poó Fernando Martín ,   Universidad Nacional de Mar del Plata, Espósito Paula ,   Universidad Nacional de Mar del Plata, Ledesma Rubén Daniel ,   Universidad Nacional de Mar del Plata
Published: August 2024

Objetivo: En la región de las Américas, y particularmente en Argentina, los usuarios de motocicleta se encuentran entre los grupos más vulnerables del tránsito. Este estudio se propuso analizar tres comportamientos de riesgo en este grupo: uso de celular, ausencia de uso de casco, y traslado de menores. Se buscó también identificar posibles factores humanos, vehiculares y ambientales asociados a esos comportamientos. Métodos: Se realizaron observaciones naturales de motociclistas que circulaban en vías pertenecientes a una ciudad de Argentina (Mar del Plata). Se trabajó con una muestra de n = 2085 ocupantes de moto (1727 conductores y 358 pasajeros). Resultados: El 72% de los ocupantes usaba casco, aunque el uso correcto fue del 63%. El uso fue menor entre los acompañantes en comparación con los conductores, entre los hombres y jóvenes, y en los usuarios particulares. Menor uso también fue observado en las zonas de mayor vulnerabilidad socio-ambiental, en las motos económicas urbanas y en los vehículos sin placa patente. Una cuarta parte de los pasajeros eran menores de 18 años. Entre los menores de 11 años, solo la mitad usaba casco. El traslado de niños/as fue más frecuente cuando conducía una mujer. El uso de celular en conductores fue del 3%, siendo más frecuente entre los motociclistas comerciales. Conclusión: Este estudio ofrece información relevante para priorizar acciones de prevención orientadas a mejorar la seguridad en el tránsito, tal como ha sido propuesto en el Plan Estratégico de la Organización Panamericana de la Salud 2020-2025.
Propuesta de formación inicial docente para la democracia y la justicia social basada en el aprendizaje servicio
Authors: García Gómez Teresa
Published: August 2024

Este artículo presenta una propuesta de formación inicial docente como proyecto pedagógico político para la educación democrática y la justicia social, resultado de una revisión y reflexión teórica. Se definen, en primer lugar, los conceptos sobre los que se sustenta dicha propuesta de formación: pedagogía, democracia y justicia social. Posteriormente, se propone la concientización para el desarrollo de dicho proyecto, entendida como el proceso que permitirá desarrollar la conciencia crítica a través de la praxis concreta, pero para ello es necesario superar una serie de dualidades, tales como: teoría y práctica, investigación y docencia, enseñanza y aprendizaje, aprendizaje individual y aprendizaje cooperativo, docente y alumnado, educación bancaria y educación problematizadora, y universidad y escuela. Por último, se propone el desarrollo de dicha praxis por medio de la metodología de aprendizaje servicio en el marco de un proyecto de investigación acción.
The Mental Health Provider Shortage in the Mexican Public Sector: 2023 estimates of psychiatrists and psychologists
Authors: Barrón-Velázquez Evalinda , Mendoza-Velásquez José Javier , Mercado-Lara Araceli , Quijada-Gaytán Juan Manuel , Flores-Vázquez Juan Francisco
Published: August 2024

Introduction. Mental health has historically been overlooked in public policies in Mexico, with up to 80% of people with mental health and substance-related disorders in Mexico lacking adequate care. Objective. To characterize the mental health provider (psychiatrists and psychologists) shortage in the Mexican public sector. Method. Descriptive study. Data from SINERHIAS (Ministry of Health of Mexico) up to the first half of 2023 were analyzed. Results. A total of 1,504 psychiatrists worked in the public sector (1.1 per 100,000 population). The Health Ministry (Secretaría de Salud; Spanish acronym SS) employed 55.9%, IMSS 25.9%, ISSSTE 7.2%, while 1.0% were affiliated to other public institutions. There were 8,668 psychologists in the public sector (6.9 per 100,000 population), of which the SS employed 78.9%, IMSS 6.3%, ISSSTE 2.4%, while 12.3% worked at other public institutions. Thirty-four per cent of psychiatrists were in Mexico City, while 21 states, accounting for 70% of the population, had one psychiatrist or fewer per 100,000 population. Hospital units employed 83.3% of psychiatrists. Discussion. Mexico has an insufficient number of mental health providers at public institutions, with disparities between states and most providers affiliated to hospital units. Conclusion. There is an acute mental health provider shortage in the Mexican public sector, together with limited resources for community mental health care, affecting the treatment of mental health and substance use disorders.
Biosynthesis of secondary metabolites in aromatic and medicinal plants in response to abiotic stresses: A review
Authors: Pradhan J. , Pramanik K. , Jaiswal A. , Kumari G. , Prasad K. , Jena C. , Srivastava Ashutosh K.
Published: August 2024

Climate change has massive consequences on non-living factors in the environment, resulting in irregular precipitation, fluctuating atmospheric temperature, and variations in humidity. These changes cause biotic and abiotic stresses; plants must have defense mechanisms to survive. Therefore, plants divert some synthesized energy towards producing numerous plant secondary metabolites (PSMs), viz., flavonoids, alkaloids, and essential oils. These compounds act as protections for the plants, helping them to survive under stressful conditions. Medicinal and aromatic plants (MAPs) are sessile organisms that are not immune to harmful consequences of various abiotic stresses in which the PSMs have an important role in acting against the adverse effects. In this regard, the MAPs have a coherent defense mechanism for abiotic stresses. The secondary metabolites produced by these plants are useful as medicines and aromatic products for humans. However, not all stresses produce high secondary metabolites, as their production is highly specific to certain stresses. This review provides a comprehensive understanding of secondary metabolite production under various stressful conditions, including extreme temperature, drought, water logging, salinity, harmful radiation, elevated levels of ozone and CO2, heavy metals, and agrochemicals on MAPs. Additionally, the production of these compounds can be modified by subjecting plants to various stressors. Many authors have reported on PSMs in MAPs, which need to be well documented and exploited for humankind.
Tamaddun: The View of Syed Muhammad Naquib Al-Attas Towards a New Concept of Islamic Civilization
Authors: Ihsan Nur Hadi , Rachmawati Fadhillah , Mohd Amin Wan Mohd Azam
Published: August 2024

This brief article aims to analyze Syed Muhammad Naquib al-Attas' thoughts on tamaddun using the philosophy of history as a theoretical framework. This research elucidates that tamaddun is a state of human social life that has reached a high level of morality (ādab) and culture for society. The critical elements of tamaddun are al-dīn, ādab, and al-'ilm, which accumulate in 'ilm, amal, and iḥsan. Al-Attas defines Islamic civilization as a civilization that arises amid the multifariousness of cultures of Muslim communities of the world as a result of the permeation of the fundamental elements of the religion of Islam, which those communities have begun to arise from inside themselves, and a manifestation of integration in multifariousness as well as of multifariousness in unity. Al-Attas wants to show that Islam has arranged the Malay-Indonesian Archipelago for the coming modern world as proof that the world has been Islamized.
Puritan, Moderate, and Liberal Youth Muslim: Islamic Identity Typology Among Generation Z Students in Indonesian Universities
Authors: Taja Nadri , Hakim Arif , Suhardini Asep Dudi , Baehaqi Riyandi , Pamungkas Muhamad Imam
Published: August 2024

The objective of this article is to examine the categorization of student’s comprehension of religion within two Indonesian universities, namely Universitas Islam Bandung and Universitas Pendidikan Indonesia, due to the presence in promoting Islamic values by offering Islamic religious education subject and religious mentoring programs in the curriculum that have a significant impact on student’s religious beliefs. The research employed a cross-sectional survey with descriptive analysis and utilized a sample of 139 students from both universities. It identified three typologies of Islamic identities within the students: first, the Puritans, who are identical to the Indonesian Salafist local leader Yazid bin Abdul Qadir Jawas; second, the moderate Islam, influenced by Yusuf al-Qardhawi's teaching; and third, the liberal, associated with Ulil Abshar Abdala's Jaringan Islam Liberal movement. The findings are: The students enrolled in the Islamic Religious Education at Universitas Islam Bandung showed a predominant inclination towards the Puritans (50-53.3%), the moderate (30%), and the liberal (16.7-20%), respectively. Within Universitas Pendidikan Indonesia's student reveals a trend towards the Puritans (30-43.3%), the moderate (26.7- 50%), and the liberal (20-30%), respectively. This shows there is a strong inclination towards the Puritans within both universities, and it is recommended that both universities formulate policies and strategies for strengthening religious moderation.
Beyond The Classroom: Empowering Social Care Character Through Islamic Education Via Student Executive Board
Authors: Mardhiah Izzatul , Amaliyah Amaliyah , Mintarja Endang , Faidlaani Akhmad , Izzudin Ahmad
Published: August 2024

Islamic Education (IE) in Higher Education is a compulsory course in Indonesia. However, it still dominantly assesses the cognitive aspect, while the learning competency of Islamic Education aims to form the religious character and social attitudes of students. Therefore, this study aims to develop indicators of student social care integrated with student organization activities. The indicator of social concern that has been validated and meets the content validity score will be used as a measuring tool for the attitude and skill components of students in Islamic Education learning. The process of developing indicators of social care integrated into student organization activities requires the ADDIE model development research method (Analysis, design, development, implementation, and evaluation, but in this study, there are only three stages: the first needs analysis, the second planning, and third development. The research subjects were students and lecturers of Islamic Education at Universitas Negeri Jakarta, Universitas Pendidikan Indonesia, and Universitas Muhammadiyah Jakarta. Data collection tools are questionnaires, interviews, and documentation studies. Data analysis used the Aikens Index and inter-rater reliability to see the suitability of the content of the indicator with the theory used and to see the agreement of experts in assessing the developed social care indicators. The results of the research based on the needs analysis by surveying 25 students from student organization members in three universities through quota, purposive sampling, and interviews found that 80% of students were involved in BEM social activities, and 72% of students agreed to integrate social activities of student organizations in PAI learning. The results of the Aiken Index content validity test of six skill indicators and four social care attitude indicators were a minimum score of 0.83 and a highest score of 0.91. The reliability test result is 0.64. These results indicate that three experts have agreed upon the content of social care indicators, and then it is feasible to construct a validity test to find out the indicators developed that can measure students' social attitudes and skills using the theory used.