bluuebunny/crossref_metadata_2025 huggingface dataset:
Entrevista a la Dra. Eva Ortega Paino, Presidente de la Red de Científicos Españoles en el Exterior y directora científica del Biobanco del Centro Nacional de Investigación Oncológicas (CNIO)
Authors: Berbey Álvarez Aranzazu
Published: March 2022

Doctora en C.C. Químicas por la Universidad Complutense de Madrid en la especialidad de Bioquímica y Biología Molecular. Su carrera científica se sitúa principalmente en Suecia (Universidad de Lund)  y Noruega donde ha trabajado tanto en industria como academia.  Aparte de su trabajo científico, Eva ha ostentado también los cargos de Presidente del Consejo de Residentes de Españoles (CRE) en Suecia, Consejera por Suecia en el CGCEE (Consejo General de la ciudadanía española en el exterior), vicepresidenta de la ACES (Asociación de Científicos Españoles en Suecia). Actualmente es la Secretaria General de RAICEX, Embajadora de ACES en España y la Directora Científica del Biobanco del Centro Nacional de Investigaciones Oncológicas (CNIO) en Madrid, España.
José María Figueroa Oreamuno: hombre de ciencia, historia y arte costarricense
Authors: Hernández Vega Henry , D'Alolio Sánchez Ileana
Published: March 2022

José María Figueroa Oreamuno, se destacó por su labor en diferentes áreas durante el siglo XIX. Además de explorador se destacó en las áreas de etnografía, historia y cartografía. Además, sobresale como ilustrador y caricaturista. Su investigación genealógica no tiene igual en la Centroamérica de su época. Su trabajo histórico recopila información de cuatro siglos diferentes.  El aporte de José María Figueroa es un monumento a la historia y cultura de Costa Rica.
Olimpia R. Altuve: Farmacéutica y Química Bióloga guatemalteca
Authors: Borrayo Morales Ana Patricia
Published: March 2022

Altuve fue la primera mujer guatemalteca titulada con el grado de licenciada en la «Universidad Nacional Estrada Cabrera». Un caso extraordinario para la época debido a que eran pocas las mujeres que lograban el ingreso a los estudios universitarios y sobre todo porque irrumpían un espacio que durante siglos había sido exclusivo de los hombres. En consecuencia, como mujer antecesora en la educación superior, le correspondió ser la primera graduada universitaria en Guatemala. Desde finales del siglo XIX, la matricula estudiantil femenina persistía como una prerrogativa masculina, por lo tanto, el promedio de mujeres inscritas en la educación superior manifestaba una exigua presencia en las aulas universitarias.  Fue hasta el 23 de noviembre de 1919 que Olimpia Altuve logró el grado de licenciada en farmacia. Sin duda alguna, un proceso arduo dadas las condiciones sociales para un nuevo quehacer social de las mujeres. No obstante, eran mujeres que provenían de sectores sociales acomodados y además disponían del beneplácito de su entorno social para proseguir los estudios universitarios. En la segunda década del siglo XX, Olimpia logró culminar su carrera universitaria y formó parte de la primera generación de profesionistas guatemaltecas. Además, creó un precedente histórico que generó un camino con nuevos imaginarios para cimentar los espacios necesariamente diferentes para las mujeres.
Методика оцінювання ефективності логістичного забезпечення угруповання різнорідних сил (військ)
Authors: Avramenko Oleksandr , Kotsyuruba Volodymyr , Datsenko Ivan
Published: March 2022

Окупація Криму і підтримка Російською Федерацією сепаратистських рухів у Луганській та Донецькій областях засвідчили хибність актуальних до недавнього часу оцінок воєнно-політичної обстановки, що склалася навколо України, а також внутрішніх та зовнішніх загроз національним інтересам держави. Аналіз проведення антитерористичної операції на території Донецької та Луганської областей (Операції Об’єднаних Сил) свідчить, що системи тилового, технічного, медичного та інших видів забезпечення потребувала швидкої адаптації до реальної обстановки, форм та способів застосування частин (підрозділів) на різних етапах її проведення. В контексті європейської інтеграції і нових завдань Збройних Сил України, пов’язаних з участю України в антитерористичних операціях, в миротворчій діяльності під егідою НАТО та ООН, виникає потреба реформування військ (сил), видів тилового, технічного та медичного забезпечення відповідно до вимог стандартів НАТО. В зазначеній статті розроблено методику оцінювання ефективності логістичного забезпечення угруповання різнорідних сил (військ) Військово-Морських сил в особливий період. В ході проведеного авторами дослідження використані базові положення теорії складних технічних систем, теорії штучного інтелекту, таксономічного методу, а також загальнонаукові методи аналізу та синтезу. Зазначена методика дозволяє оцінити ефективність системи логістичного забезпечення угруповання різнорідних сил (військ) Військово-Морських сил в особливий період, визначити заходи спрямовані на удосконалення логістичного забезпечення. На основі зазначеної методики авторами буде проведено розробку рекомендацій щодо удосконалення логістичного забезпечення угруповання різнорідних сил (військ) Військово-Морських Сил в Азовській операційній зоні в особливий період.
Метод прогнозування ризиків виникнення збройного конфлікту на основі результатів аналізу обсягів воєнних витрат
Authors: Solomitsky Alexey , Semenenko Oleh , Onofriichuk Petro , Slyusarenko Marina , Baranov Sergey , Mitchenko Sergey
Published: March 2022

Мета роботи: полягає у визначенні змісту та порядку проведення розрахунків методом прогнозування ризиків виникнення збройного конфлікту на основі результатів аналізу воєнних витрат.

Дизайн/Метод/Підхід дослідження: методом прогнозування ризиків виникнення збройного конфлікту на основі результатів аналізу воєнних витрат.

Практична цінність дослідження: запропонований метод цілком можливо використовувати під час моніторингу воєнно-політичної обстановки. Він дозволить: - спростити процедури розрахунків та моніторингу;

- усунути необхідність у збиранні та обробленні великих масивів вхідних даних;

- це надасть можливість розв’язання оптимізаційної задачі з визначення раціонального обсягу воєнних витрат із забезпеченням належного рівня інтенсивності процесу;

- прогнозувати виникнення збройного конфлікту;

- розробляти рекомендації військово-політичному керівництву держави щодо завчасного реагування на загрози.

Тип статті: практична.
Роль інформаційних ресурсів державної прикордонної служби України у забезпеченні її інформаційної безпеки
Authors: Torichnyi Vadym , Burmaka Andrii
Published: March 2022

Мета роботи: полягала в аналізі поняття інформаційних ресурсів у забезпеченні прикордонної безпеки держави як складової національної.

Дизайн/Метод/Підхід дослідження: основними способами дослідження були: пошуково-інформаційний (з метою систематизації та впорядкування інформаційної основи); системний та предметний аналіз (для уточнення змісту ключових понять з проблеми дослідження); аналіз стану проблеми у Державній прикордонній службі України; аналіз наукової та методичної літератури, словниково-довідникової літератури; аналіз зміст у (суттєвих ознак) визначенні понять “інформаційний ресурс” (знання, події та явища, як її форми).

Результати дослідження: уточнено основні завдання інформаційного забезпечення прикордонного відомства: своєчасна обробка інформації від зовнішнього та внутрішнього середовища; розміщення інформації; здійснення процесів організації, зберігання та трансферу інформації; створення досконалої інформації системи; застосування сучасних інформаційно-комунікаційних технологій; підвищення продуктивності діяльності представників відомства тощо.

Оригінальність дослідження: в ході дослідження виявлено: сприйняття інформаційного забезпечення як динамічної системи інформаційних ресурсів та варіантів їх обробки, задля вивчення реального стану об’єктів; виділено фактори, котрі на них впливають.

Теоретична цінність полягає у компіляції популярних наукових поглядів із проблеми дослідження.

Практична цінність дослідження полягає у тому, що визначено особливості сутність та завдання інформаційного забезпечення прикордонної служби України.

Майбутні дослідження: Перспективними напрямами подальших наукових досліджень є питання удосконалення процесів, групування, пошуку, систематизації та поширення інформації у прикордонному відомстві, а також їх вплив на управлінську діяльність.

Тип статті: теоретична.
Українська військово-економічна ядерна бомба вже розірвалася у економіці Росії (ретроспектива, дійсне та майбутнє)
Authors: Semenenko Oleh , Dobrovolskyi Yuzef , Yarmolchyk Maria , Rakhmanyi Oleksandr , Tarasov Oleh , Remez Artem
Published: March 2022

Мета роботи: розкрити ретроспективу підготовки Росії до війни з Україною, визначити основні воєнно-економічні особливості та наслідки впливу російсько-української війни на економіку Росії, сформувати можливі прогнозовані варіанти стану економіки Росії від розвитку сценаріїв та тривалості ведення бойових дій між Росією та Україною.

Дизайн/Метод/Підхід дослідження: основними методами досліджень є методи статистичного аналізу, воєнно-економічного аналізу, експертного опитування та методи прогнозування.

Результати дослідження: проведено аналіз динаміки стану економіки Росії до початку російсько-української війни, визначено вплив введених санкцій проти Росії на її економіку сьогодні та зроблено прогнозування стану рецесії економіки Росії за різних варіантів розвитку воєнних дій  та їх тривалості, а також сформовано можливі воєнно-економічні ризики  для Росії у подальшому.

Теоретична цінність дослідження: Основним результатом  досліджень за тематикою статті є формування бази вихідних даних щодо наслідків дії української воєнно-економічної бомби на економіку Росії  з урахуванням аналітичних ретроспективних результатів участі Росії у попередніх війнах та збройних конфліктах.

Тип статті: описовий та розрахунково-аналітичний.
PENGARUH PEMBELAJARAN DARING TERHADAP STRES PADA MAHASISWA FARMASI
Authors: Suryawati Ayu Widya , Monica Eva , Tambun Sabrina Handayani
Published: March 2022

Pada akhir tahun 2019, dimulai munculnya virus yang diduga berasal dari Wuhan, China yaitu Covid-19. Virus ini dapat menyebar dari individu satu dengan individu yang lain. Setelah beberapa waktu lalu, penyebaran hingga terjadi di beberapa negara termasuk Indonesia, hingga WHO mengumumkan Covid-19 sebagai pandemi, untuk mencegah penyebarannya maka kegiatan akademis di Indonesia dialihkan menjadi metode pembelajaran jarak jauh atau dalam jaringan (daring). Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pembelajaran daring terhadap stres pada mahasiswa farmasi.
Jenis penelitian ini adalah kuantitatif dengan pendekatan cross sectional, cara pengambilan data adalah dengan cara menyebarkan kuesioner secara online yaitu melalui google form kepada 100 responden. Kemudian dianalisis dengan uji Chi Square dan uji Rank Spearman. Hasil dari penelitian ini adalah responden yang menilai bahwa pembelajaran daring tidak efektif dengan tingkat stres ringan adalah sebanyak 29 responden (69.0%) dan tingkat stres sedang adalah sebanyak 13 responden (31.0%), sedangkan responden yang menilai pembelajaran daring efektif dengan tingkat stres ringan adalah sebanyak 42 responden (72.4%) dan tingkat stres sedang adalah sebanyak 16 responden (27.6%). Hasil dapat disimpulkan bahwa dari 100 responden, responden cenderung berada pada tingkat stres ringan dan sebagian besar mahasiswa menganggap pembelajaran daring efektif untuk dilakukan.
PENGARUH PEMBERIAN EDUKASI TERHADAP TINGKAT PENGETAHUAN PERILAKU HIDUP BERSIH DAN SEHAT PHBS DAN PROTOKOL KESEHATAN PADA WARGA PACITAN SEBAGAI UPAYA PENCEGAHAN COVID 19
Authors: Indasari Rika Dwi , Susanto Haryanto , Monica Eva
Published: March 2022

COVID-19 adalah penyakit infeksi saluran pernafasan yang disebabkan coronavirus (SARS CoV-2) dengan gejala umum berupa demam, sakit tenggorokan, sesak nafas, dan dapat menular melalui droplet dari pasien terinfeksi. Upaya pencegahan penyebaran COVID-19 dapat dilakukan dengan menerapkan Perilaku Hidup Bersih dan Sehat (PHBS) dan protokol kesehatan. Pemberian edukasi tentang PHBS dan protokol kesehatan diharapkan dapat meningkatkan pengetahuan masyarakat tentang PHBS dan protokol kesehatan sebagai upaya pencegahan COVID-19 sehingga dapat meningkatkan perilaku masyarakat dalam melakukan pencegahan penularan COVID-19.

Penelitian ini dilakukan dengan rancangan penelitian one-group pretest-posttest dengan memberikan kuesioner kertas sebelum dan setelah pemberian edukasi. Edukasi dilakukan dengan metode ceramah dengan menggunakan media slide dan flipchart. Pengolahan data menggunakan SPSS dengan uji non parametrik Wilxocon.

Pada uji statistik Wilcoxon diperoleh nilai signifikansi 0,000 yang berarti H0 ditolak, H1 diterima yang artinya terdapat perbedaan yang signifikan pada tingkat pengetahuan masyarakat tentang PHBS dan protokol kesehatan sebagai upaya pencegahan COVID-19 sebelum dan sesudah diberikan edukasi.
Association between fatty acid signature and growth rate of larval Pacific bluefin tuna in two major spawning grounds
Authors: Hiraoka Y , Ishihara T , Tawa A , Tanaka Y , Ohshimo S , Ando Y
Published: March 2022

Fatty acid composition and total fatty acids of field-caught Pacific bluefin tuna (PBF) Thunnus orientalis larvae were investigated to identify relationships between spawning ground, physiological condition, and growth rate. Multivariate statistical analyses revealed that both growth rate and environmental conditions at spawning grounds were substantially associated with variations in fatty acid compositions. Fast-growing larvae typically contained more α-linolenic acid and 22:5n-3, which are important as metabolic precursors of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Larval PBF fatty acid compositions differed by spawning ground; larvae caught around the Nansei Islands contained more 15:0, 17:0, 19:0, and 22:5n-6, and less EPA and arachidonic acid (ARA) than those from the Sea of Japan. Differences in larval odd-numbered fatty acid compositions might indicate different degrees of dependence on microbial loop energy supply between spawning grounds. Environments subject to sudden changes, such as those in water temperature and prey density in the Sea of Japan, might cause variability in fatty acid profiles, including extremely low %DHA. We suggest that continuous food intake and subsequent fatty acid catabolism for energy generation would be needed to facilitate fast growth.
Environmental DNA detects a possible Japanese eel spawning event near a video-recorded anguillid eel in the open ocean
Authors: Takeuchi A , Higuchi T , Kuroki M , Watanabe S , Miller MJ , Okino T , Miwa T , Tsukamoto K
Published: March 2022

Facultative catadromous eels migrate back to the sea to reproduce, but their spawning behavior and locations have remained elusive. Using environmental DNA (eDNA), we identified a likely spawning site location and time of spawning of the Japanese eel. We detected Japanese eel eDNA at 400 and 600 m and recorded a likely sighting of this species at about 220 m using a deep-tow camera system 6 d before the new moon. A strong eDNA signal was obtained at 400 m from the apparent spawning event the morning after the estimated peak of eel spawning, 3 d before the new moon. These findings indicate that Japanese eels were already within the area where they were going to spawn at least 6 d before the new moon and then may have spawned near the strong eDNA station 3 d before the new moon. We concluded that the eDNA analysis is useful in searching for spawning sites and determining the timing of spawning of aquatic organisms with external fertilization that causes a temporary surge in eDNA, although prior knowledge of likely spawning sites is needed.
Physical water compartments: a revised concept of perinatal body water physiology
Authors: Sulyok E
Published: March 2022

This review presents experimental data on the perinatal significance of the recently developed concept of physical water compartments. This concept implies that in addition to the compartmentalization of body water into the intra- and extracellular spaces, motionally distinct water fractions - designated as physical water compartments - are also of importance in the neonatal body fluid redistribution. H(1)-NMR spectroscopy provides a quantitative estimate of tissue water fractions with different mobility as multicomponent analysis of the T(2) relaxation decay curves allows us to determine the fast and slow relaxing components of the curves corresponding to the bound and free fractions of tissue water. Using this method, free and bound water fractions were measured in fetal and neonatal rabbit tissues (skin, skeletal muscle, liver, brain, lung) at different stages of maturity and under conditions of various fluid intake. It has been demonstrated that water mobility in individual fetal/neonatal tissues varies greatly and there is a general tendency of increasing free water at the expense of bound water fraction with progressing maturation. This tendency appears to be accelerated in the immediate postnatal period when the tissue water content is markedly reduced. The importance of hyaluronan in this process has also been addressed as the hyaluronan content is markedly elevated in the fetal/neonatal tissues and due to its polyanionic, hydrophilic nature it has been claimed to play a prominent but not clearly defined role in the control of tissue hydration.
PPAR-alpha and insulin sensitivity
Authors: Haluzík MM , Haluzík M
Published: March 2022

Peroxisome proliferator-activated receptors (PPAR) belong to the nuclear receptor superfamily of ligand-activated transcription factors. PPAR-alpha, first of its three subtypes (alpha, beta, gamma) has traditionally been considered an important regulator of lipid metabolism while its role in the regulation of insulin sensitivity has not been recognized until recently. Here we summarize the experimental and clinical studies focusing on the role of PPAR- alpha in the regulation of insulin sensitivity. In most of the experimental studies the activation of PPAR-alpha in rodents leads to improvement of insulin sensitivity by multiple mechanisms including improvement of insulin signaling due to a decrease of ectopic lipids in non-adipose tissues and decrease of circulating fatty acids and triglycerides. In contrast, the effect of PPAR-alpha agonist in humans is much less pronounced probably due to a lower expression of PPAR-alpha relative to rodents and possibly other mechanisms. Further clinical studies using more potent PPAR-alpha agonists on a larger population need to be performed to evaluate the possible role of PPAR- alpha in the regulation of insulin sensitivity in humans.
The effects of short-term training on platelet functions and total antioxidant capacity in rats
Authors: Ficicilar H , Zergeroglu AM , Ersoz G , Erdogan A , Ozdemir S , Tekin D
Published: March 2022

The purpose of the present study was to investigate the effect of short-term endurance training on plasma total antioxidant status (TAS) and on in vitro platelet aggregation and ATP release. Blood samples were collected from the abdominal aorta of rats following short-term treadmill exercise (25 m/min, 0 % grade, 30 min) for three consecutive days, as well as in non-exercised control group. Platelet aggregation and platelet ATP release were evaluated by impedance and bioluminescence techniques, respectively. Plasma TAS was measured spectrophotometrically. Plasma TAS was higher and ADP-induced platelet ATP release was lower in the short-term training group with respect to the control group (p<0.001). Significant negative correlation (r = -0.56, p<0.05) was found between plasma TAS and ADP-induced platelet ATP release. Neither ADP- and collagen-induced maximum aggregation rate nor collagen-induced platelet ATP release were significantly different between the groups. According to these results, short-term training caused an alteration in platelet functions limited to the secretion response, which may be related to the oxidant/antioxidant balance changes favoring the antioxidants. The improved plasma total antioxidant capacity was possibly sufficient to prevent exercise-induced oxidative damage, and the adaptive response of platelets might be associated with enhanced antioxidant status.
Products of DNA, protein and lipid oxidative damage in relation to vitamin C plasma concentration
Authors: Krajčovičová-Kudláčková M , Dušinská M , Valachovičová M , Blažíček P , Pauková V
Published: March 2022

Oxidative stress plays an important role in the pathogenesis of numerous chronic age-related free radical-induced diseases. Improved antioxidant status minimizes oxidative damage to DNA, proteins, lipids and other biomolecules. Diet-derived antioxidants such as vitamin C, vitamin E, carotenoids and related plant pigments are important in antioxidative defense and maintaining health. The results of long-term epidemiological and clinical studies suggest that protective vitamin C plasma concentration for minimum risk of free radical disease is higher than 50 micromol/l. Products of oxidative damage to DNA (DNA strand breaks with oxidized purines and pyrimidines), proteins (carbonyls) and lipids (conjugated dienes of fatty acids, malondialdehyde) were estimated in a group of apparently healthy adult non-smoking population in dependence on different vitamin C plasma concentrations. Under conditions of protective plasma vitamin C concentrations (>50 micromol/l) significantly lower values of DNA, protein and lipid oxidative damage were found in comparison with the vitamin C-deficient group (<50 micromol/l). The inhibitory effect of higher fruit and vegetable consumption (leading to higher vitamin C intake and higher vitamin C plasma concentrations) on oxidation of DNA, proteins and lipids is also expressed by an inverse significant correlation between plasma vitamin C and products of oxidative damage. The results suggest an important role of higher and frequent consumption of protective food (fruit, vegetables, vegetable oils, nuts, seeds and cereal grains) in prevention of free radical disease.
Inhibitory transmission, activity-dependent ionic changes and neuronal network oscillations
Authors: Jedlička P , Backus KH
Published: March 2022

Oscillatory network activity arises from interactions between synaptic and intrinsic membrane properties of neurons. In this review, we summarize general mechanisms of synchronous neuronal oscillations. In addition, we focus on recent experimental and computational studies which suggest that activity-dependent changes of ionic environment can affect both the synaptic and intrinsic neuronal properties and influence the network behavior. GABA(A) receptor (GABA(A)R)-mediated signaling, that is based on Cl(-) and HCO(3)(-) permeability, is thought to be important for the oscillogenesis and synchronization in cortical networks. A remarkable feature of GABAergic synapses is that prolonged GABA(A)R activation may lead to switching from a hyperpolarizing to a depolarizing response. This is partly due to a positive shift of the GABA(A) R reversal potential (E(GABA)) that is generated by GABA-induced Cl(-) accumulation in neurons. Recent studies suggest that activity-dependent E(GABA) changes may have important implications for the mechanisms of gamma oscillations and seizure-like discharges. Thus, a better understanding of the impact of intracellular Cl(-) dynamics on network behavior may provide insights into the mechanisms of physiological and pathological brain rhythms. Combination of experiments and simulations is a promising approach for elucidating which properties of the time-varying ionic environment can shape the dynamics of a given circuit.
Caspase 3 activation in the primary enamel knot of developing molar tooth
Authors: Matalová E , Kovářů F , Míšek I
Published: March 2022

Mammalian teeth develop during embryogenesis as epithelio-mesenchymal organs. The primary enamel knot is considered as a signaling center in tooth morphogenesis. After tooth bell formation, this epithelial structure undergoes apoptosis. Activation of caspase 3 represents a crucial step in the intracellular death machinery. Procaspase 3 and caspase 3 molecules were localized in the primary enamel knot of the field vole using immunohistochemistry. Different fixation procedures in cryopreserved and paraffin-embedded tissues and detection systems based on peroxidase and alkaline phosphatase mediated color reactions were applied. Apoptosis was detected using morphological criteria and the TUNEL assay. Procaspase 3 was found in both the epithelial and mesenchymal part of the tooth germ. Active caspase 3 was localized particularly in the primary enamel knot, its distribution correlated with dental apoptosis and showed a similar pattern in the field vole as in the mouse.
Fire Detection System Using Android-Based Microcontroller
Authors: Jani Akbar Rafni Rafsan , Handayani Dwipa , Noeman Achmad
Published: March 2022

The Fire Detection System can be supported by Internet of Things technology, e.g. a Microcontroller device which is used to control the related devices. In this study, android-Based fire detection system was designed in which the house owner can always monitor the condition of the house all the times and accessing the information about their house when a fire occurs until the fire suppression process is complete. Information of the house condition will be displayed on the Blynk application which is located in the kitchen area and is connected to several supporting sensors. The design of a Fire Detection System Using an Android-Based Microcontroller is divided into several stages, namely: (1) Requirement Identification; (2) Requirement Analysis;(3) Hardware Design; (4) The software design (Arduino IDE 1.8.5 and Blynk). The testing results showed that the android-based Fire Detection System Using Microcontroller was able to provide information to residents of the house in the real-time.
Computer-Based Test Application to Support E-Learning in Pandemic Situation
Authors: Marifati Imam Soleh , Mulyanto Joko Dwi , Kesuma Chandra , Ubaidillah Ubaidillah , Suripah Suripah
Published: March 2022

The use of information technology in education is a new breakthrough. During the current COVID-19 pandemic, many teaching and learning activities are carried out online using the internet in the form of e-learning. one important part of e-learning is the test. Computer based test (CBT) can be implemented in schools that should be accessed by students from remote places. Computer-based test applications can be used as a complement to online learning by utilizing the web technology. Web-based applications allows access by students with an internet connection using PC/Laptop or other mobile devices. In addition, implementation costs can be saved because paperless. Computer-based test applications also make it easier for teachers to grade the answer where the application can automatically provide the score instantly when students finish the test. In this study, the application was built using the web technology that run from various devices and platforms. Access applications can be designed for local network use (intranet) or online by hosting the application on a webserver. The application development uses a system development life cycle approach using PHP-MySQL technology.

 

Keyword : CBT, computer base test, PHP-MySQL, webapps.
TO WHAT EXTENT DOES ORGANIZATIONAL CULTURE INFLUENCE ORGANIZATIONAL PERFORMANCE? EVIDENCE FROM THE DEPARTMENT OF POPULATION AND CIVIL REGISTRATION, TRENGGALEK REGENCY, EAST JAVA PROVINCE
Authors: Baidhowah Adfin Rochmad
Published: March 2022

Cultural aspects within an organization will determine the direction of the performance of an organization whether leading to a better pendulum or toward a stagnant pendulum. The issue of the performance of e-ID card service in the Department of Population and Civil Registry of Trenggalek Regency shows the absence of aspect in organizational culture which has an impact on the organization's performance whether it is evaluated objectively internal government and objectively from the viewpoint of the service recipient community. Organizational culture is a system of shared meanings embraced by members who distinguish an organization from other organizations. This shared system of meanings, when examined more thoroughly, is a set of key characteristics valued by an organization. Research on the influence of organizational culture on organizational performance in the Department of Population and Civil Registry of Trenggalek Regency using quantitative method with survey research approach conducted on the object of research. The influence of organizational culture variable (X) toward organizational performance (Y) shows the total influence of p = 0,584 or 58,4% and t value equal to 2,099 and t value table equal to 1,985, giving meaning that there is significant influence of organizational culture variable as Independent variable toward performance variable. And the value of the effect of epsilon variables ie other variables not studied in this study, that is equal to 0.416 or 41.6%.

Key Words: Organizational Culture, Organizational Performance and eKTP Service.
INOVASI QR CODE PADA PENCETAKAN DOKUMEN DATA PENDUDUK SEBAGAI WUJUD PENERAPAN ASAS PENYELENGGARAAN PEMERINTAHAN
Authors: Mubaroq Husni , Fitria Nurul Jannah Lailatul
Published: March 2022

The Indonesian government has made reforms to the system of governance. Included in the system of administration of government administration. This form of renewal is by optimizing the use of information and communication technology which is increasingly sophisticated and coupled with an internet base. This renewal is called innovation with elements of technological sophistication, bringing the Indonesian government as a form of bureaucratic digitization or E-government. One of these reforms or innovations is in the Population Administration sector. The Directorate General of Dukcapil has the innovation of implementing document printing by adding a QR Code. The goal is to make public services in the population administration sector easier, better, and consistent with the principle of protecting population data. This study will describe the QR Code innovation on population documents in accordance with the principles of governance in Probolinggo City. This research method applies descriptive-oriented qualitative. The data input method is by observing phenomena related to the object of research and obtaining data from literature studies. So that it can be seen that the QR Code is a form of innovation by the Probolinggo City government in public services in the population administration sector in accordance with the legislation containing the principles of governance.

Key Words: Population Administration, Barcodes, Public service.
Rule of Law and Access to Justice: Construction of an Accessibility Index of Primary Justice Fora in Paraguay
Authors: Recalde Ramirez Luis
Published: March 2022

The main objective of the study is to create an index that measures the population’s spatial accessibility to primary justice fora in Paraguay, identifying areas that need additional resources to improve such access. The data used for the analysis include all households registered in the 2012 census in Paraguay, with their corresponding geographic coordinates, as well as all available geodata for selected justice-related public services within the same studied area. The methodology proposed is the application of a minimum distance analysis, together with a point proximity buffer analysis. Results show that districts located in the Central department of Paraguay have the highest accessibility index in the country, while those locate in the Chaco area have the lowest. Similarly, population size seems to be a relevant factor that play into the supply side of justice fora.
O ensino do basquetebol no contraturno escolar: um relato de experiência a partir das novas tendências de ensino dos esportes
Authors: Maciel Larissa Fernanda Porto , Feriato Marlene , Folle Alexandra
Published: March 2022

A literatura sobre treinamento atlético tem direcionado a atenção para o esporte em clubes e centros esportivos e pouca atenção tem sido dada ao esporte dentro do contexto escolar. Objetivo: relatar os resultados alcançados na formação de crianças e adolescentes, por meio da experiência em oficinas de basquetebol, no contraturno escolar. Método: trata-se de um estudo descritivo, do tipo relato de experiência. A amostra foi constituída por crianças e adolescentes, de ambos os sexos, com idade de 10 a 18 anos, participantes de oficinas de basquetebol propostas por uma escola de basquete que atua no contraturno escolar em dois colégios privados da Grande Florianópolis (SC/Brasil). Utilizou-se a análise de informações contidas em registros pedagógicos (diário de campo) das aulas e relatos emitidos por familiares. Resultados e discussão: os resultados encontrados evidenciaram que nos colégios em que foram ofertadas as oficinas de basquetebol, houve um aumento do envolvimento dos alunos com os estudos e aspectos positivos no comportamento dos jovens foram observados por pessoas próximas, como familiares e professores. Conclusões: pode-se concluir que a oferta do basquetebol dentro da escola, pautada em uma metodologia focada na interação entre os alunos e na diversidade de movimentos que o esporte possui, tem fomentado o envolvimento dos praticantes tanto no esporte como nos estudos.
Unihoc como deporte alternativo en el ámbito educativo.
Authors: Hernández-Beltrán Víctor , Gámez-Calvo Luisa , Gamonales José M.
Published: March 2022

Este trabajo aborda la inclusión de deportes alternativos en las clases de Educación Física. Mediante el uso de los juegos alternativos en las sesiones de Educación Física, se pueden desarrollar diferentes objetivos del currículo, así como fomentar valores esenciales, aumentar la participación de los alumnos y alumnas durante las clases y a su vez, la motivación y atracción por las clases de Educación Física. Para desarrollar los deportes alternativos en el aula, es importante la implementación de la metodología comprensiva, partiendo de los aspectos más globales del deporte y poco a poco centrando la atención en aspectos más técnicos. Por ello, en este documento se recogen los aspectos básicos de juego del UniHoc con el objetivo de facilitar a los docentes de Educación Física el desarrollo de este deporte en las sesiones de Educación Física. Algunos de los beneficios de los deportes alternativos es su gran aceptación por parte de todo el alumnado debido a que sus reglas son simples y permiten mucha versatilidad pudiendo ser adaptadas a diferentes necesidades. Por último, los deportes alternativos ayudan a proponer nuevas situaciones educativas y recreativas.
Prevalencia de bullying en estudiantes de 12 a 16 años: conductas de acoso y conductas de acoso de género
Authors: Gómez-Galán Rafael , Mendoza-Muñoz Maria , Arroyo-Girón Rocio , Muñoz-Bermejo Laura
Published: March 2022

Introducción: Proliferan estudios a nivel mundial tratando de concluir sobre la naturaleza, prevalencia, factores de riesgo, consecuencias y formas de prevención e intervención en el bullying. Objetivo: Determinar la prevalencia de bullying y factores relacionados en estudiantes adolescentes de una región de Córdoba, España. Métodos: Se realizó un estudio de corte transversal en 325 estudiantes (48,9 % mujeres) con edades entre 12 y 16 años (M=14,97; DE=1,4) pertenecientes a 12 centros educativos. El bullying fue evaluado mediante el Cuestionario de Acoso entre Iguales (CAI). Se realizó un estudio descriptivo de las conductas de acoso y de acoso de género realizando un análisis bivariado y multivariado, para determinar la asociación entre las diferentes conductas de acoso y las variables sociodemográficas sexo y edad de los participantes. Resultados: La prevalencia de bullying fue 19,1%. Se encontró asociación significativa entre género y acoso mediante amenazas, exclusión social indirecta y maltrato físico. A más jóvenes sufren un mayor maltrato verbal y se sienten excluidos socialmente de forma directa. Aquellas chicas consideradas poco atractivas, y los chicos cuyo comportamiento difiere de los estereotipos de su género o van poco con chicas, tienen más probabilidades de sufrir acoso escolar. Conclusiones: Los resultados permiten concluir la relevancia del problema del acoso escolar y asociar a diversos factores y comportamientos de riesgo, que deberían ser analizados con detalle para diseñar e implementar programas preventivos apropiados.
Comparação da Força e Flexibilidade em jovens atletas femininas- Ginastas versus Patinadoras
Authors: Cabo Carolina Alexandra , Parraça José Alberto
Published: March 2022

Este será um estudo transversal, observacional e comparativo de jovens atletas femininas para ajudar a desenvolver duas capacidades físicas essenciais: a força e a flexibilidade. O objetivo será caracterizar descritiva e comparativamente a força e a flexibilidade de praticantes de Ginástica e de Patinagem Artística. Além disso pretendemos perceber em que medida se observavam influências mútuas entre as variáveis avaliadas. Os participantes são 35 atletas femininas de ginástica (9.8 ± 2.05 anos) e 35 atletas femininas de patinagem artística (10,57 ± 2,66 anos). Foram avaliados níveis de força e flexibilidade através da Bateria de Testes do FitEscola. O estudo comparativo paramétrico realizado sinalizou diferenças estatisticamente significativas (p=0,02) em apenas uma prova: no teste de abdominais, o seu valor (t=-2,30) sinaliza melhores resultados no grupo das patinadoras. O estudo correlacional paramétrico (r de Pearson) sinalizou correlações estatisticamente significativas entre as variáveis de desempenho, no entanto apenas encontrámos uma associação positiva (p=0,02) entre a variável grupo e a força abdominal. Os resultados obtidos mostram que não foram observáveis diferenças significativas entre ginastas e patinadoras na maioria das qualidades físicas avaliadas. A exceção foram os resultados obtidos na avaliação da força abdominal e da flexibilidade dos membros inferiores. No entanto, as pequenas diferenças que não chegam a ser significativas devem-se ao facto de nesta idade as atletas ainda não realizarem trabalhos específicos de força, sendo o enfase dado às habilidades motoras coordenativas para que a técnica seja melhorada.
Bio-Inspired Hierarchical Micro/Nanostructured Surfaces for Superhydrophobic and Anti-Ice Applications
Authors: Zhang Lansheng , Uzoma Paul C. , Xiaoyang Chu , Penkov Oleksiy V. , Hu Huan
Published: March 2022

We report a scalable and cost-effective fabrication approach for constructing bio-inspired micro/nanostructured surfaces. It involves silicon microstructure etching using a deep reactive ion etch (DRIE) method, nanowires deposition via glancing angle deposition (GLAD) process, and fluorocarbon thin film deposition. Compared with the smooth, microstructured, and nanostructured surfaces, the hierarchical micro/nanostructured surfaces obtained via this method showed the highest water contact angle of ∼161° and a low sliding angle of <10°. It also offered long ice delay times of 2313 s and 1658 s at −5°C and −10°C respectively, more than 10 times longer than smooth surfaces indicating excellent anti-icing properties and offering promising applications in low-temperature environments. These analyses further proved that the surface structures have a significant influence on surface wettability and anti-icing behavior. Hence, the GLAD process which is versatile and cost-effective offers the freedom of constructing nanostructures on top of microstructures to achieve the required objective in the fabrication of micro/nanostructured surfaces when compared to other fabrication techniques.
Usefulness of Platelet Distribution Width and Fibrinogen in Predicting In-stent Restenosis With Stable Angina and Type 2 Patients With Diabetes Mellitus
Authors: Chai Dayang , Yang Xi , Wang Aichao , Lu Shu , Dai Yuxiang , Zhou Jing
Published: March 2022

Aim

The purpose of this study was to investigate the predicting value of platelet distribution width (PDW) and fibrinogen for in-stent restenosis (ISR) in patients with stable angina pectoris and type 2 diabetes mellitus (T2DM) after drug-eluting stent (DES) implantation.

Methods

We enrolled 161 patients who were readmitted with recurrent chest pain and successfully reviewed for coronary angiography and were divided into the ISR and non-ISR groups. We compared the levels of PDW and fibrinogen between the two groups. Logistic regression was used for analyzing independent predictors of ISR. The receiver operating characteristic (ROC) curve analysis was used to determine the optimum cutoff points of PDW and fibrinogen to predict ISR. The Kaplan–Meier survival curves for target lesion failure (TLF) by levels of PDW and fibrinogen.

Results

The multivariate logistic regression analysis showed that PDW and fibrinogen were independent predictors of ISR [odds ratio (OR) = 1.209, 95% CI: 1.024–1.427, p = 0.025; OR = 1.006, 95% CI: 1.002–1.011, p = 0.010, respectively]. The ROC analyses showed that PDW ≥ 13.15% and fibrinogen ≥ 333.5 mg/dl were predictive of ISR in patients with stable angina pectoris and T2DM after DES implantation. However, the Kaplan–Meier estimate for TLF showed no statistical significance.

Conclusion

Higher levels of PDW and fibrinogen were associated with the incidence of ISR in patients with stable angina with T2DM after DES implantation, but were not independent predictors of TLF.
A Novel Idiopathic Atrial Calcification: Pathologic Manifestations and Potential Mechanism
Authors: Li Bowen , Liu Qingbo , Chen Xihui , Chen Tangdong , Dang Wenhui , Zhao Jing , Cui Guangbin , Chen Kun , Wu Yuanming
Published: March 2022

Background

Cardiac calcification is a type of ectopic pathologic calcification of unknown etiology and mechanisms. Once diagnosed, the location, extent and morphology of the calcified lesions, as well as their functional significance in the heart, are usually the focus of case reports. Calcification is mostly distributed in myocardium, but rarely reported in atrium. In addition, because of limited sampling and complex pathological mechanisms, the etiology underlying the formation of these calcified lesions also remains unclear.

Methods

Two cardiac calcifications were found in a patient, died of trauma-induced subarachnoid hemorrhage after slightly drinking, during a standard autopsy. The location and morphological characteristics of the calcified lesions were determined by computed tomography (CT) and CT-based 3D reconstruction. The specific histopathological characteristics of the lesions were determined by multi-staining. The concentration of free calcium and inorganic pyrophosphate (PPi) in plasma reflected the change of calcium metabolism. The expression and membranal localization of the ATP Binding Cassette Subfamily C Member 6 (ABCC6) in hepatocytes were detected by immunofluorescence. The variants of the ABCC6 were detected by Sanger sequencing and potential pathogenic variants were further identified by in silico analysis.

Results

The present study describes a patient with idiopathic calcification with two pear-shaped and irregularly hollow lesions symmetrically distributed in the patient's atrium. Massive accumulation of calcium salts was identified by multi-staining. For this patient, the plasma concentration of free calcium was higher than the control, indicating that calcium metabolism was disturbed. Furthermore, the plasma PPi of the patient was lower than the normal. By using immunofluorescence, the expression and membranal localization of ABCC6 was decreased and impaired in hepatocytes, respectively. Combined with Sanger sequencing and in silico analysis, 7 variants were identified.

Conclusions

This study described a novel patient with symmetrically distributed idiopathic atrial calcifications. Furthermore, all the results indicated that these pathologic calcifications may be secondary to reduced plasma PPi content due to ABCC6 dysfunction in hepatocytes. Moreover, these findings provided novel clues to the pathogenesis, clinical diagnosis and treatment of idiopathic atrial calcification in future.
Co-Expression Network Modeling Identifies Specific Inflammation and Neurological Disease-Related Genes mRNA Modules in Mood Disorder
Authors: Yang Chunxia , Zhang Kun , Zhang Aixia , Sun Ning , Liu Zhifen , Zhang Kerang
Published: March 2022

Objectives: Mood disorders are a kind of serious mental illness, although their molecular factors involved in the pathophysiology remain unknown. One approach to examine the molecular basis of mood disorders is co-expression network analysis (WGCNA), which is expected to further divide the set of differentially expressed genes into subgroups (i.e., modules) in a more (biologically) meaningful way, fascinating the downstream enrichment analysis. The aim of our study was to identify hub genes in modules in mood disorders by using WGCNA.

Methods: Microarray data for expression values of 4,311,721 mRNA in peripheral blood mononuclear cells drawn from 21 MDD, 8 BD, and 24 HC individuals were obtained from GEO (GSE39653); data for genes with expression in the bottom third for 80% or more of the samples were removed. Then, the top 70% most variable genes/probs were selected for WGCNA: 27,884 probes representing 21,840 genes; correlation between module genes and mood disorder (MDD+BD vs. HC) was evaluated.

Results: About 52% of 27,765 genes were found to form 50 co-expression modules with sizes 42–3070. Among the 50 modules, the eigengenes of two modules were significantly correlated with mood disorder (p < 0.05). The saddlebrown module was found in one of the meta-modules in the network of the 50 eigengenes along with mood disorder, 6 (IER5, NFKBIZ, CITED2, TNF, SERTAD1, ADM) out of 12 differentially expressed genes identified in Savitz et al. were found in the saddlebrown module.

Conclusions: We found a significant overlap for 6 hub genes (ADM, CITED2, IER5, NFKBIZ, SERTAD1, TNF) with similar co-expression and dysregulation patterns associated with mood disorder. Overall, our findings support other reports on molecular-level immune dysfunction in mood disorder and provide novel insights into the pathophysiology of mood disorder.
Chromosomal Rearrangements and Origin of the Multiple XX/XY1Y2 Sex Chromosome System in Harttia Species (Siluriformes: Loricariidae)
Authors: Deon Geize Aparecida , Glugoski Larissa , Sassi Francisco de Menezes Cavalcante , Hatanaka Terumi , Nogaroto Viviane , Bertollo Luiz Antônio Carlos , Liehr Thomas , Al-Rikabi Ahmed , Moreira-Filho Orlando , Cioffi Marcelo de Bello , Vicari Marcelo Ricardo
Published: March 2022

The Neotropical genusHarttiacomprises species with extensive chromosomal remodeling and distinct sex chromosome systems (SCSs). So far, three different SCSs with male heterogamety have been characterized in the group. In some species, the presence of the XX/XY1Y2SCS is associated with a decrease in diploid numbers and several chromosomal rearrangements, although a direct relation to sex chromosome differentiation has not been shown yet. Here, we aimed to investigate the differentiation processes that have led to the establishment of the rare XX/XY1Y2SCS and track its evolutionary history among otherHarttiaspecies. For that, four whole chromosome painting probes derived from chromosome 1 ofH. torrenticola(HTO-1), chromosomes 9 and X ofH. carvalhoi(HCA-9 and HCA-X), and chromosome X fromH. intermontana(HIN-X) were applied in nineHarttiaspecies. Homeologous chromosome blocks were located inHarttiaspecies and demonstrated that Robertsonian (Rb) fusions originated HTO-1, HCA-9, and HCA-X chromosomes, while Rb fissions explain Y1and Y2sex chromosomes. Specifically, inH. intermontana, HCA-X, HCA-9, and the NOR-bearing chromosome demonstrated that homeologous blocks were used in the HIN-X and metacentric pair 2 origins. Consequently, diploid numbers changed between the studied species. Overall, the data also reinforce the existence of unstable genomic sites promoting chromosomal differentiation and remodeling within the genusHarttia.