bluuebunny/crossref_metadata_2025 huggingface dataset:
Moquiniastrum (Asteraceae, Gochnatioideae, Gochnatieae) na Região Sul do Brasil
Authors: Freitas Karen Araújo de , Christ Anderson Luiz , Ritter Mara Rejane , Miotto Silvia Teresinha Sfoggia
Published: September 2020

Resumo Moquiniastrum, originalmente descrito por Cabrera como uma seção de Gochnatia, após análises moleculares e morfológicas mais detalhadas foi elevado à categoria de gênero. Moquiniastrum diferencia-se de Gochnatia pela presença de ginodioicia, indumento de tricomas com 2-5-raios e capitulescências paniculiformes. Atualmente é constituído por 21 espécies, distribuídas principalmente no Brasil. Pouco se conhece sobre a taxonomia do gênero Moquiniastrum e ainda há escassez de estudos sobre o arranjo sexual das flores no capítulo, necessitando de análises aprofundadas destas estruturas. O objetivo geral deste trabalho foi realizar um estudo taxonômico de Moquiniastrum na Região Sul do Brasil, além de avaliar e enquadrar os táxons em categorias de ameaça de extinção. Este estudo foi realizado através de revisões de herbários e expedições de campo nos três estados da Região Sul do Brasil. Foram encontradas 10 espécies de Moquiniastrum, além de três subespécies de M. polymorphum. São fornecidos chave de identificação para os táxons confirmados, descrições morfológicas, comentários sobre habitats, conservação e períodos de floração e de frutificação das espécies, além de observações taxonômicas e imagens.
Sinopse de Licófitas e Samambaias do Parque Nacional da Amazônia, Pará, Brasil
Authors: Menezes Edson Alves , Labiak Paulo Henrique
Published: September 2020

Resumo Neste trabalho é apresentado um levantamento das samambaias e licófitas do Parque Nacional da Amazônia, Pará, Brasil. Este é um dos maiores Parques da bacia amazônica e agrega os principais tipos vegetacionais das terras baixas da Amazônia. Coletas foram realizadas entre 2015 e 2016, e os espécimes estão depositados no herbário INPA, UPCB e HSTM. Registrou-se 83 espécies, das quais uma é um novo registro para o Pará (Selaginella cabrerensis). As famílias com maior riqueza de espécies são Pteridaceae (19 spp.), Polypodiaceae (12 spp.), Hymenophyllaceae (8 spp.), Selaginellaceae (6 spp.) e Aspleniaceae (5 spp). Dentre os gêneros, Adiantum apresenta maior riqueza, com 13 espécies, seguido por Microgramma e Selaginella (6 spp., cada), e Asplenium e Trichomanes (5 spp., cada). A maioria das espécies é terrícola, em ambientes de terra-firme. Neste trabalho apresentamos chaves de identificação para famílias, gêneros e espécies, lista de material examinado, comentários e ilustrações.
Frutas nativas do Rio Grande do Sul, Brasil: riqueza e potencial alimentício
Authors: Brack Paulo , Köhler Matias , Corrêa Claudine Abreu , Ardissone Rodrigo Endres , Sobral Marcos Eduardo Guerra , Kinupp Valdely Ferreira
Published: September 2020

Resumo O Brasil é o país com a maior biodiversidade conhecida no mundo, mas sua flora alimentícia ainda carece de estudos. No presente trabalho, apresentamos um levantamento de plantas frutíferas nativas do estado do Rio Grande do Sul com base em consultas bibliográficas e experimentação de campo. Dados adicionais de cada espécie, como nome popular, forma biológica, distribuição geográfica, hábitat, fenologia, tamanho da fruta e forma de uso também são apresentados. Reportamos 213 espécies frutíferas nativas distribuídas em 48 famílias e 102 gêneros, sendo Myrtaceae a família com o maior número de espécies. A maioria das espécies é constituída por árvores que ocorrem em ambientes florestais, distribuídas ao longo de todo território do estado. Mais de 90% das frutas são para consumo in natura ou derivados, enquanto uma pequena parte é utilizada após processamento, e outra parte é utilizada como condimento. Cerca de 20% das espécies são apresentadas de maneira inédita como frutíferas. Ressalta-se a elevada riqueza de espécies frutíferas encontrada no estado e a importância da valorização da flora nativa alimentícia com potencial de uso sustentável, incrementando a fruticultura local e agregando valor à produção agrícola.
Turneraceae (Passifloraceae s.l.) na Região Sul do Brasil
Authors: Cabreira Thaíssa Nunes , Miotto Silvia Teresinha Sfoggia
Published: September 2020

Resumo Este trabalho compreende o levantamento florístico da família Turneraceae na Região Sul do Brasil. Foram confirmados 17 táxons, sendo cinco pertencentes ao gênero Piriqueta (P. cistoides subsp. cistoides, P. sidifoliavar. sidifolia, P. pampeana, P. suborbicularis e P. taubatensis), e 12 correspondentes ao gênero Turnera (T. capitata, T. hilaireana, T. oblongifolia var. oblongifolia, T. orientalis, T. serrata var. brevifolia, T. sidoides subsp. carnea, T. sidoides subsp. holosericea, T. sidoides subsp. integrifolia, T. sidoides subsp. pinnatifida, T. sidoides subsp. sidoides, T. subulata e T. weddelliana). São fornecidas descrições com ilustrações, fotografias, chaves de identificação para os gêneros e para as espécies, considerações sobre distribuição geográfica, habitat, floração e frutificação.
Avaliação social como recurso persuasivo em discursos políticos: Clinton vs. Trump
Authors: Oliveira Ulisses Tadeu Vaz de
Published: September 2020

RESUMO Mudanças políticas têm intensificado os debates sobre como certos discursos estabelecem agendas e influenciam eleitores. Nesse escopo, a Análise Crítica do Discurso e a Linguística Sistêmico-Funcional, juntamente com o arcabouço teórico-metodológico da Avaliatividade, demonstraram ser bem-sucedidas na investigação da ideologia em textos, bem como na abordagem de tópicos como a polarização política. Portanto, a presente pesquisa tem como objetivo analisar a avaliação social da Teoria da Avaliatividade como um dispositivo ideológico e persuasivo nos discursos de nomeação de Clinton e Trump, em 2016. Os resultados enfatizam usos de estratégias retóricas que podem levar os eleitores à preferência de certos conjuntos de valores e crenças. A análise revelou que, naqueles discursos, os candidatos usaram estratégias diferentes para persuadir os eleitores, construindo abordagens discursivas ideológicas negativas (Trump) e positivas (Clinton), aplicando a avaliação social como estratégia retórica central.
O conceito de compreensão em Bakhtin e o Círculo: reflexões para pensar o processo educativo
Authors: Lima Guilherme da Silva
Published: September 2020

RESUMO A compreensão é um processo que fundamenta a atividade educativa e permite o desenvolvimento do ensino e da aprendizagem. Este artigo apresenta um esforço teórico para sintetizar o conceito de compreensão presente nas contribuições de Bakhtin e do Círculo, baseado em uma revisão das obras Marxismo e filosofia da linguagem. Problemas fundamentais do método sociológico na ciência da linguagem e O freudismo, bem como dos ensaios Os gêneros do discurso, presente na coletânea Estética da criação verbal, e O discurso no romance, da coletânea Questões de literatura e de estética: a teoria do romance, de M. Bakhtin. De acordo com o Círculo, a compreensão é composta por elementos concretos, ideológicos e axiológicos, além de ser um processo que permite a representação e o prolongamento da atividade comunicativa.
Treatment of adult patient with hyperdivergent retrognathic phenotype and anterior open bite: report of a case with non-surgical orthodontic approach
Authors: Santo Jr Marinho Del
Published: September 2020

ABSTRACT Adult patients with anterior open bite and hyperdivergent retrognathic phenotype demand complex treatments, as premolar extractions, molar intrusion or orthognathic surgery. In the present clinical case, a young adult patient without significant growth, with Class I and anterior open bite, was treated with four premolar extractions. The therapeutic result shows good intercuspation, good facial esthetic, good function balance, and stability in a two-year post-fixed treatment follow-up.
Space closure using aligners
Authors: Machado Ricardo Martins
Published: September 2020

ABSTRACT Introduction: Due to the search for more aesthetic and comfortable alternatives to perform orthodontic treatments and to the great technological development, orthodontic aligners have assumed great importance. More and more complex treatments have been carried out with these appliances without, however, having all aspects involved in their use being studied in depth. Its biomechanical planning requires different approaches than those used in fixed orthodontics, as the force systems involved in movements, responses and side effects are distinct, and the professional must be prepared when opting for the technique. Objective: The objective of this article is to perform an evaluation of the force systems created on the space closure with aligners, its characteristics, and problems, as well as make some suggestions to overcome the difficulties inherent to its use. Conclusion: Space closure with aligners is possible, but depends on the correct selection of the patient, in addition to requiring the proper planning of the applied forces. The use of auxiliary resources and overcorrections to address the deficiencies of the aligner systems should always be considered. Digital planning should be used as a map of the force systems that will be applied, and not just as a marketing tool, keeping in mind that determining the objectives and the way to achieve them is the responsibility of the orthodontist, and that treatment plans must be individualized for each situation, following appropriate biomechanical precepts.
Incisor root length in individuals with and without anterior open bite: a comparative CBCT study
Authors: Arriola-Guillén Luis Ernesto , Valera-Montoya Ivy Samantha , Rodríguez-Cárdenas Yalil Augusto , Ruíz-Mora Gustavo Armando , Aliaga-Del Castillo Aron , Janson Guillerme
Published: September 2020

ABSTRACT Objective: This study aimed to compare the root length of maxillary and mandibular incisors between individuals with open bite versus matched individuals with adequate overbite. Methods: This comparative, matched and retrospective study included 48 cone beam computed tomographies (CBCTs) obtained at a university radiological center. Scans belonged to 24 individuals with open bite (overbite ≤ 0 mm) and 24 individuals with adequate overbite (controls). Both groups were matched by age, sex, malocclusion classification and skeletal characteristics (ANB and FMA angles). Root length of each maxillary and mandibular incisor was measured in millimeters (mm) in a sagittal section from a perpendicular line to the enamel cement junction until the root apex (384 length measurements were made). The means of root length in both groups were compared using t-tests. In addition, correlations between variables were evaluated with the Pearson correlation coefficient (α = 0.05). Results: In both groups, the root length of the upper central incisors was approximately 12 mm and the root length of the maxillary lateral incisors was approximately 13 mm (p˃ 0.05). Likewise, the root length of lower central incisors in both groups measured approximately 12 mm (p˃ 0.05). However, the mandibular lateral incisor roots of open bite patients were significantly longer than in the normal overbite patients (approximately 1 mm, p= 0.012 right side, p= 0.001 left side). Conclusions: Root length of maxillary incisors and central mandibular incisor is similar in individuals with or without open bite, but the mandibular lateral incisor roots in open bite patients were significantly longer than in the normal overbite patients.
OIKONOMIA PENTECOSTAL reflexões teológico-econômicas sobre religião e neoliberalismo
Authors: Reinhardt Bruno
Published: September 2020

Resumo O artigo revisita debates recentes sobre a teologia econômica e explora a produtividade analítica deste conceito para se pensar a relação contemporânea entre o neopentecostalismo e o neoliberalismo. Toma como referência etnográfica as redes de discipulado da denominação ganense Lighthouse Chapel International e seu projeto apostólico bem sucedido de replicação transnacional em filiais. A teologia econômica desta organização é abordada através das ressonâncias entre modos cristãos de governo e subjetivação e dispositivos da racionalidade neoliberal, como capital humano, trabalho imaterial e afetivo e habilidades de administração de emoções.
ENSINO SUPLEMENTAR NO CONTEXTO BRASILEIRO: UMA ANÁLISE BASEADA NOS DADOS DO ENEM
Authors: Galvão Fernando Vizotto
Published: September 2020

RESUMO Dialogando com a literatura que trata de shadow education, assim como com elementos da abordagem bourdieusiana, os quais tratam das relações entre o espaço social e as práticas dos indivíduos, este artigo procura explorar, a partir dos dados do Exame Nacional do Ensino Médio (ENEM) de 2008, a existência ou não de padrões de participação em cursos suplementares. Submetidos à Análise de Correspondências Múltiplas, os dados revelaram homologias e distinções relativas à participação em diferentes cursos suplementares, assim como certa relação entre os padrões de participação em determinados cursos e a condição social dos estudantes.
Study of the physical and mechanical properties of permeable concrete with the addition of TiO 2 for the treatment of sewage
Authors: Araújo Wendel Melo Prudêncio de , Avelino Flávio Pessoa , Picanço Marcelo de Souza , Macêdo Alcebíades Negrão
Published: September 2020

ABSTRACT: The sewage treatment stations (STSs), located in Teresina-PI, were designed to receive domestic sewage, however, in 2011 they began to receive unknown sewer from clean pit vehicles. This sewage is compromising the effluent treatment efficiency. The permeable concrete with the addition of titanium dioxide (TiO 2 ) presents itself as an alternative process to assist in the treatment of sanitary sewage due to its photocatalytic properties. Therefore, the objective of this work was to evaluate the mechanical, hydraulic, and microstructural properties of permeable concrete with the addition of 3, 6 and 10% of TiO 2 . The results determined that the variation in the concentration of TiO 2 significantly influenced the properties analyzed in this research. The addition of TiO 2 to the permeable concrete to a concentration of 6% impairs its physical and hydraulic properties and improves its mechanical properties.
Adequação de protocolos de classificação de risco para COVID-19 às orientações da OMS: uma proposta de instrumento
Authors: Garcia Leandro Pereira , Willemann Maria Cristina Antunes , Boing Alexandra Crispim , Amaral Fernanda Vargas , Vidor Ana Cristina , Machado Patrícia Maria de Oliveira , Moreira Natália , De Sousa Tatiane Cristina Moraes , Barberia Lorena , Traebert Jefferson , Lacerda Josimari Telino de
Published: September 2020

Objetivo: Este artigo propõe criar um instrumento para analisar a adequação de protocolos de classificação de risco para COVID-19 às orientações da Organização Mundial de Saúde (OMS) e analisa o protocolo utilizado por Santa Catarina. Método: A pesquisa descritiva foi composta de três partes: 1) extração de informações concernentes à análise de risco e à COVID-19 dos documentos da OMS; 2) elaboração de instrumento para análise da adequação de protocolos de classificação de risco para COVID-19 às orientações da OMS; 3) aplicação do instrumento ao protocolo utilizado no estado de Santa Catarina. Resultados: Cinco documentos da OMS foram revistos. O instrumento construído contemplou cinco dimensões: avaliação do risco em si, avaliação da exposição, avaliação do contexto, caracterização do risco e confiabilidade. Informações parciais com relação à avaliação do risco em si e à confiabilidade foram encontradas no protocolo do governo catarinense. Não foram encontradas informações com relação às demais dimensões. Discussão: O desencontro entre a matriz utilizada pelo estado de Santa Catarina e as orientações para análise de risco da OMS são grandes. Assim, sem uma análise adequada desses fatores toda a estratégia de implementação de ações pode ser comprometida, expondo a população do estado a risco.
Long-Term Response to Intermittent Binimetinib in Patients withNRAS-Mutant Melanoma
Authors: Matter Alexandra Valeska , Micaletto Sara , Urner-Bloch Ursula , Dummer Reinhard , Goldinger Simone M.
Published: September 2020

Melanoma can be classified based on the detection of relevant oncogenic driver mutations. These mutations partially determine a patient's treatment options. MEK inhibitors have demonstrated little efficacy in patients with NRAS-mutated melanoma owing to primary and secondary resistance. We report two patients with NRAS-mutant metastatic melanoma with long-term response to intermittent MEK-inhibitor binimetinib therapy. Intermittent dosing schedules could play a key role in preventing resistance to targeted therapy. This article highlights the efficacy of an intermittent dosing schedule, toxicities associated with binimetinib, and possible mechanisms preventing resistance in targeted therapy. Intermittent MEK-inhibitor therapy may be considered in patients with NRAS-mutated melanoma that have failed all standard therapies.

Key Points

Melanomas harbor NRAS mutations in 10%–30% of the cases. These mutations promote hyperactivation of the MAPK pathway, leading to proliferation and prolonged survival of tumor cells. Currently, drugs directly targeting NRAS are not available. Downstream inhibition of the MAPK pathway can be considered as a therapeutic option after immunotherapeutic failure. Intermittent administration of kinase inhibitors might be the way to partially overcome the development of drug resistance by (a) inducing a fitness deficit for drug-resistant cells on treatment break, (b) increasing the immunogenicity, and (c) inducing apoptosis and cell cycle arrest. It also enhances expression of numerous immunomodulating molecules, and reduction of immunosuppressive factors, which suggests better access of the immune system to the tumor.
Chemoradiation-Related Lymphopenia and Its Association with Survival in Patients with Squamous Cell Carcinoma of the Anal Canal
Authors: Lee Grace , Kim Daniel W. , Muralidhar Vinayak , Mitra Devarati , Horick Nora K. , Eyler Christine E. , Hong Theodore S. , Drapek Lorraine C. , Allen Jill N. , Blaszkowsky Lawrence S. , Giantonio Bruce , Parikh Aparna R. , Ryan David P. , Clark Jeffrey W. , Wo Jennifer Y.
Published: September 2020

Background

Although treatment-related lymphopenia (TRL) is common and associated with poorer survival in multiple solid malignancies, few data exist for anal cancer. We evaluated TRL and its association with survival in patients with anal cancer treated with chemoradiation (CRT).

Materials and Methods

A retrospective analysis of 140 patients with nonmetastatic anal squamous cell carcinoma (SCC) treated with definitive CRT was performed. Total lymphocyte counts (TLC) at baseline and monthly intervals up to 12 months after initiating CRT were analyzed. Multivariable Cox regression analysis was performed to evaluate the association between overall survival (OS) and TRL, dichotomized by grade (G)4 TRL (<0.2k/μL) 2 months after initiating CRT. Kaplan-Meier and log-rank tests were used to compare OS between patients with versus without G4 TRL.

Results

Median time of follow-up was 55 months. Prior to CRT, 95% of patients had a normal TLC (>1k/μL). Two months after initiating CRT, there was a median of 71% reduction in TLC from baseline and 84% of patients had TRL: 11% G1, 31% G2, 34% G3, and 8% G4. On multivariable Cox model, G4 TRL at two months was associated with a 3.7-fold increased risk of death. On log-rank test, the 5-year OS rate was 32% in the cohort with G4 TRL versus 86% in the cohort without G4 TRL.

Conclusion

TRL is common and may be another prognostic marker of OS in anal cancer patients treated with CRT. The association between TRL and OS suggests an important role of the host immunity in anal cancer outcomes.

Implications for Practice

This is the first detailed report demonstrating that standard chemoradiation (CRT) commonly results in treatment-related lymphopenia (TRL), which may be associated with a poorer overall survival (OS) in patients with anal squamous cell carcinoma. The association between TRL and worse OS observed in this study supports the importance of host immunity in survival among patients with anal cancer. These findings encourage larger, prospective studies to further investigate TRL, its predictors, and its relationship with survival outcomes. Furthermore, the results of this study support ongoing efforts of clinical trials to investigate the potential role of immunotherapy in anal cancer.
Cyclin Pathway Genomic Alterations Across 190,247 Solid Tumors: Leveraging Large-Scale Data to Inform Therapeutic Directions
Authors: Jardim Denis L. , Millis Sherri Z. , Ross Jeffrey S. , Woo Michelle Sue-Ann , Ali Siraj M. , Kurzrock Razelle
Published: September 2020

Background

We describe the landscape of cyclin and interactive gene pathway alterations in 190,247 solid tumors.

Methods

Using comprehensive genomic profiling (315 genes, >500× coverage), samples were analyzed for alterations in activating/sensitizing cyclin genes (CDK4 amplification, CDK6 amplification, CCND1, CCND2, CCND3, CDKN2B [loss], CDKN2A [loss], SMARCB1), hormone genes (estrogen receptor 1 [ESR1], androgen receptor [AR]), and co-alterations in genes leading to cyclin inhibitor therapeutic resistance (RB1 and CCNE1).

Results

Alterations in at least one cyclin activating/sensitizing gene occurred in 24% of malignancies. Tumors that frequently harbored at least one cyclin alteration were brain gliomas (47.1%), esophageal (40.3%) and bladder cancer (37.9%), and mesotheliomas (37.9%). The most frequent alterations included CDKN2A (13.9%) and CDKN2B loss (12.5%). Examples of unique patterns of alterations included CCND1 amplification in breast cancer (17.3%); CDK4 alterations in sarcomas (12%); CCND2 in testicular cancer (23.4%), and SMARCB1 mutations in kidney cancer (3% overall, 90% in malignant rhabdoid tumors). Alterations in resistance genes RB1 and CCNE1 affected 7.2% and 3.6% of samples. Co-occurrence analysis demonstrated a lower likelihood of concomitant versus isolated alterations in cyclin activating/sensitizing and resistance genes (odds ratio [OR], 0.35; p < .001), except in colorectal, cervical, and small intestine cancers. AR and cyclin activating/sensitizing alterations in prostate cancer co-occurred more frequently (vs. AR alterations and wild-type cyclin activating/sensitizing alterations) (OR, 1.79; p < .001) as did ESR1 and cyclin activating/sensitizing alterations in breast (OR, 1.62; p < .001) and cervical cancer (OR, 4.08; p = .04) (vs. ESR1 and cyclin wild-type activating/sensitizing alterations).

Conclusion

Cyclin pathway alterations vary according to tumor type/histology, informing opportunities for targeted therapy, including for rare cancers.

Implications for Practice

Cyclin pathway genomic abnormalities are frequent in human solid tumors, with substantial variation according to tumor site and histology. Opportunities for targeted therapy emerge with comprehensive profiling of this pathway.
Sarcoma European and Latin American Network (SELNET) Recommendations on Prioritization in Sarcoma Care During the COVID-19 Pandemic
Authors: Martin-Broto Javier , Hindi Nadia , Aguiar Samuel , Badilla-González Ronald , Castro-Oliden Victor , Chacón Matias , Correa-Generoso Raquel , Álava Enrique , Donati Davide María , Eriksson Mikael , Falla-Jimenez Martin , German Gisela , Gobo Silva Maria Leticia , Gouin Francois , Gronchi Alessandro , Haro-Varas Juan Carlos , Jiménez-Brenes Natalia , Kasper Bernd , Lopes de Mello Celso Abdon , Maki Robert , Martínez-Delgado Paula , Martínez-Said Hector , Martinez-Tlahuel Jorge Luis , Morales-Pérez Jose Manuel , Muñoz-Casares Francisco Cristobal , Nakagawa Suely A. , Ortiz-Cruz Eduardo Jose , Palmerini Emanuela , Patel Shreyaskumar , Moura David S. , Stacchiotti Silvia , Sunyach Marie Pierre , Valverde Claudia M. , Waisberg Federico , Blay Jean-Yves
Published: September 2020

Background

The COVID-19 outbreak has resulted in collision between patients infected with SARS-CoV-2 and those with cancer on different fronts. Patients with cancer have been impacted by deferral, modification, and even cessation of therapy. Adaptive measures to minimize hospital exposure, following the precautionary principle, have been proposed for cancer care during COVID-19 era. We present here a consensus on prioritizing recommendations across the continuum of sarcoma patient care.

Material and Methods

A total of 125 recommendations were proposed in soft-tissue, bone, and visceral sarcoma care. Recommendations were assigned as higher or lower priority if they cannot or can be postponed at least 2–3 months, respectively. The consensus level for each recommendation was classified as “strongly recommended” (SR) if more than 90% of experts agreed, “recommended” (R) if 75%–90% of experts agreed and “no consensus” (NC) if fewer than 75% agreed. Sarcoma experts from 11 countries within the Sarcoma European-Latin American Network (SELNET) consortium participated, including countries in the Americas and Europe. The European Society for Medical Oncology-Magnitude of clinical benefit scale was applied to systemic-treatment recommendations to support prioritization.

Results

There were 80 SRs, 35 Rs, and 10 NCs among the 125 recommendations issued and completed by 31 multidisciplinary sarcoma experts. The consensus was higher among the 75 higher-priority recommendations (85%, 12%, and 3% for SR, R, and NC, respectively) than in the 50 lower-priority recommendations (32%, 52%, and 16% for SR, R, and NC, respectively).

Conclusion

The consensus on 115 of 125 recommendations indicates a high-level of convergence among experts. The SELNET consensus provides a tool for sarcoma multidisciplinary treatment committees during the COVID-19 outbreak.
Supportive Strategies for Breaking Bad News via Telemedicine
Authors: Calton Brook A.
Published: September 2020

This letter to the editor proposes techniques for use in telemedicine, especially as related to delivering difficult news by video.
Cancer and Risk of COVID-19 Through a General Community Survey
Authors: Lee Karla A. , Ma Wenjie , Sikavi Daniel R. , Drew David A. , Nguyen Long H. , Bowyer Ruth C. E. , Cardoso M. Jorge , Fall Tove , Freidin Maxim B. , Gomez Maria , Graham Mark , Guo Chuan-Guo , Joshi Amit D. , Kwon Sohee , Lo Chun-Han , Lochlainn Mary Ni , Menni Cristina , Murray Benjamin , Mehta Raaj , Song Mingyang , Sudre Carole H. , Bataille Veronique , Varsavsky Thomas , Visconti Alessia , Franks Paul W. , Wolf Jonathan , Steves Claire J. , Ourselin Sebastien , Spector Tim D. , Chan Andrew T. ,   on behalf of the COPE consortium
Published: September 2020

Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.
Single-Agent Versus Double-Agent Chemotherapy in Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma: Prospective, Randomized, Multicenter Phase II Clinical Trial
Authors: Zhao Zhenhuan , Wen Yixue , Liao Dongbiao , Miao Jidong , Gui Yan , Cai Hongwei , Chen Yang , Wei Min , Jia Qiang , Tian Honggang , Sun Mingqiang , Zhang Yu , Feng Gang , Du Xiaobo
Published: September 2020

Lessons Learned

The efficacy of single-agent chemotherapy was not significantly different from that of double-agent chemotherapy in concurrent chemoradiotherapy for inoperable esophageal squamous cell carcinoma. Single-agent concurrent chemoradiotherapy had lower gastrointestinal and hematologic toxicity. Overall survival and progression-free survival were not significantly different between single- and double-agent concurrent chemoradiotherapy.

Background

This multicenter, randomized, phase II trial aimed to compare the efficacy and safety of single-agent concurrent chemoradiotherapy using the oral fluoropyrimidine S-1 with those of double-agent concurrent chemoradiotherapy using S-1 and cisplatin in patients with inoperable esophageal squamous cell carcinoma.

Methods

Patients with inoperable esophageal squamous cell carcinoma (clinical stages I to III) were randomly allocated to the single-agent group (S-1) or the double-agent group (S-1/cisplatin). The concurrent intensity-modulated radiation therapy plan was similar for both groups: planning target volume 1.8 Gy/f*30–33f and planning gross target volume of 2 Gy/f*30–33f. The primary outcome measure was the endoscopic complete response rate.

Results

Of the 105 patients randomized, 89 were assessable. The endoscopic complete response rate was 46.9% (23/49) in the single-agent group and 52.5% (21/40) in double-agent group. The median progression-free survival within a median follow-up of 23 months was 20 and 21 months, respectively. The median overall survival was 26 months and not reached, respectively. Grade 3 hematological toxicities occurred in 4.1% and 27.5% of the patients in the single- and the double-agent group, respectively.

Conclusion

Single-agent chemotherapy in concurrent chemoradiotherapy for inoperable esophageal squamous cell carcinoma has good efficacy and safety, thus warranting a phase III trial.
Application of carbon-fibre-reinforced polymer to low-strength concrete bridge piers
Authors: Saeed Hafiz Zain , Khan Qaiser uz Zaman , Iqbal Muhammad , Ahmed Afaq
Published: September 2020

The failure of most reinforced concrete structures is due to inadequate seismic design and detailing, poor construction techniques and/or the use of low-strength concrete (LSC). Retrofitting such structures with fibre-reinforced polymer wrapping rather than traditional concrete or steel jacketing is an emerging popular strengthening technique. In the research reported in this paper, carbon-fibre-reinforced polymer (CFRP) was used for external confinement of LSC bridge pier columns, which resulted in appreciable improvements in flexural strength and load-carrying capacity. Experimental tests and numerical simulations of quarter-size CFRP-wrapped circular columns under quasi-static cyclic loading were performed to evaluate the improvement in lateral load-carrying capacity. The results revealed that the confining action of the CFRP wrapping resulted in significant enhancements in the strength and ductility properties of the columns. It enhanced their energy dissipation capabilities and made them more able to tolerate even larger earthquake forces without an appreciable loss in stiffness.
Understanding the influence of properties of fine recycled aggregates on recycled concrete
Authors: Sosa María Eva , Zega Claudio Javier , Di Maio Angel Antonio
Published: September 2020

Scarcity of fine natural aggregates suitable for concrete, the pollution caused by their mining and the great environmental impact produced by the final disposal of waste concrete, have all motivated several studies about their use as recycled aggregates for concrete, particularly the fine fraction. The use of fine recycled concrete aggregates (FRCAs) is directly linked to the feasibility of obtaining target properties in concrete. Agreement about FRCA's technical viability has not yet been achieved. In this paper, the properties of FRCA associated with different features of the parent concrete and with the performance of recycled aggregate concrete prepared with them were analysed. The results show that the FRCA paste content is not linked to the compressive strength level of the parent concrete. In addition, the total water-to-cement ratio in recycled aggregate concrete seems to have a greater influence on concrete performance compared with quality and composition of FRCA.
Abstracts of current foreign publications
Authors: Akhaladze G. G. , Akhaladze D. G.
Published: September 2020

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SİYASÎ OLAYLARIN HAMDÂNÎ SİKKELERİNDEKİ YANSIMALARI
Authors: AYDOĞDU Günnur
Published: September 2020

Siyasî, kültürel, ekonomik, dînî vb. gelişmelerin sikkeler üzerinde izlenebildiği artık bilinen bir gerçektir. Bundan hareketle, çalışmada, Hamdânîlerin tarihi süreçleri içerisinde yaşanan siyasi olayların ne şekilde ve ne kadarının sikkelerine yansıdığı ortaya konmaya çalışılmıştır. Öncelikle Hamdânîler Dönemi’ne ait günümüze ulaşabilmiş, yayımlanan veya web sitelerinde verilen koleksiyonlardaki örnekler ışığında, tasarım-form, üzerinde yer alan yazılar ve diğer özellikler tespit edilmiştir. Asıl gaye olarak da, genel ve özel karakterlerinin belirlenmesi neticesinde, özelde siyasi/tarihi olaylarla ilintilerin ortaya konulması ve genelde Hamdânî sikkelerinin etraflıca tanıtılması amaçlanmıştır. Hamdânî sikkeleri üzerinde yer alan halife isimleri ya da darp sahibi emirlerin adları, çalışmanın ortaya koyduğu bir yenilik değildir. Bunlar zaten kroniklerden, tarihi vesikalardan elde ettiğimiz ve şimdiye kadar bilinen verilerdir. Ancak bunların dışında, sikkeler analiz edildiğinde dikkati çeken, akla gelen, nedir, neden vb. sorular ile çözümlenmesi gereken durumlar ilginç verilere ulaşılmasına neden olmaktadır. Sikkelerle ilgili soruların cevabı, o dönemdeki sosyal, siyasal, kültürel ve ekonomik olaylarla ilgili olabilmektedir. Bu bilgiler bazen kroniklerde açıkça bahsedilmeyen, fakat doğru okuma ve değerlendirme sonucu fark edilen gelişmeler de olabilmektedir. Nitekim Hamdânî sikkelerinde bu tür ipuçlarına rastlanılmıştır. Bunlar açıklanmaya ve detaylandırılmaya çalışılmıştır. Bu olaylara aynı zamanda sikkelerin içerdiği gizli anlamlar/bilgiler olarak da bakılabilir. Bütün bunlar gösteriyor ki, hak ettikleri ilginin ötesinde, sikkelerin her birinin ayrı ayrı ele alınarak üzerinde durulması ve gizemli dünyalarının ortaya konulması, gerçeğin bilinmesi adına çeşitli bilim dalları için zorunludur.
ÜNİVERSİTE RADYOLARININ YÖNETSEL İŞLEYİŞİ, TÜRKİYE ÖRNEKLEMİNDE BETİMSEL BİR ANALİZ
Authors: KIYIK KICIR Güzin , DEMİR Fatma Nur , ÖZAYDEMİR Nebiye
Published: September 2020

Radyo yıllar geçse de güncelliğini koruyup, aynı zamanda dinleyici üzerinde etkisi devam eden bir kitle iletişim aracıdır. Radyolar için önemli olan insan kaynağını yetiştirme konusunda üniversite radyoları önemli bir misyona sahiptir. Türkiye’de açılan iletişim fakülteleriyle birlikte sayıları her geçen gün artan üniversite radyolarının yönetsel yapıları bu çalışma ile incelenmektedir. Araştırmanın temel amacı yönetim fonksiyonlarının Türkiye’deki üniversite radyolarında nasıl uygulandığını tespit etmek ve yönetsel işleyişi belirmeye çalışmaktır. Çalışmada katılımcı olan Türkiye’deki üniversite radyolarının yöneticilerine, görüşme soruları yöneltilmiş ve gelen yanıtlar betimsel olarak analiz edilmiştir. Sonuç olarak üniversite radyolarının yönetimlerinde kurumların hedef kitle ortaklığı ve amaç birliğine sahip olduğu görülmüştür. Buna bağlı olarak yayın planlamalarından, yetki sorumluluk yapılarına, finansal işleyişten, insan kaynağını yetiştirme süreçlerine kadar birçok boyutta kurumlar arasında benzerlik tespit edilmiştir. Ayrıca yapılan işin niteliği ve çalışan profilinin öğrenci ağırlıklı olması nedeniyle yönetsel fonksiyonların resmi ve bürokratik bir işleyişten uzak olduğu ortaya çıkmıştır.
TİCARİ ÇEKİM MODELİNDE ÇOKLU DİRENÇ FAKTÖRÜ VE TÜRKİYE’NİN DIŞ TİCARET EĞİLİMİNİN DEĞERLENDİRMESİ
Authors: YÜCER Ayçıl
Published: September 2020

İlk defa Anderson ve van Wincoop (AvW, 2003) tarafından ortaya atılan Çoklu Direnç Faktörünün (Multilateral Resistance Term), çekim modeli ile yapılan tahminlemelerde değişkenlerin sapmasız ölçülebilmesi için modelde kontrol edilmesi önemlidir. Temelde, ihracat ve ithalatçıların ülke pazarlarına erişimlerinde karşılaştıkları ticaret maliyetlerini yansıtan teorik bir fiyat endeksi olarak yorumlayabileceğimiz “çoklu direnç”, dünya ülkelerinin toplam ihracat ve ithalat hacimlerinin eşit olması zorunluluğunun (pazarın temizlenme şartı) basit bir sonucudur ve en açık şekliyle, rekabetin küresel olduğunu ifade eder. Bu çalışma kapsamında gerçekleştirilen literatür taraması ve metaveri analizi sonucunda Türkiye için yapılan çekim modeli uygulamalarında, çoklu direnç faktörünün çoğunlukla yer almadığı tespit edilmiştir. Buradan hareketle çalışmada, çoklu direnç faktörünün çekim modelindeki yeri ve önemi uluslararası literatürdeki tartışmalar çerçevesinde vurgulanacak ve 1980-2018 yılları için 97 ülkenin çift yönlü ihracat hacimlerinin kullanıldığı bir ampirik çalışma yardımıyla yapısal modelin doğru tahminlenmesinde Havuzlanmış EKK, Sabit ve Rassal Panel Etkiler arasından en uygun yöntem araştırılacaktır. Ayrıca, çekim modeli yardımıyla elde edilen sabit katsayı tahminleri ile ülkelerin çoklu direnç faktörünü de içeren ihracat ve ithalat eğilimleri hesaplanacak ve aralarında bir karşılaştırma yapılacaktır. Bu karşılaştırma ile Türkiye’nin ticari yapısının temel belirleyenleri; ekonomik büyüklük, ikili ilişkiler, rekabetçi pozisyon ve çoklu direnç, ekseninde analiz edilerek hangi noktalarda güçlü veya zayıf kaldığı tanımlanacaktır.
ASUR KAYNAKLARINDA ARAPLAR VE ARAP KRALLIKLARI
Authors: TOPTAŞ Koray
Published: September 2020

Araplar, Asur yazılı belgelerinde ve sarayların duvarlarını süsleyen rölyeflerde kendilerine yer edinmişlerdir. Arapların Asur kaynaklarına konu olması, onların önemli ticaret güzergâhlarından birisinin kontrolünü ellerinde tutmaları, aramotikler ve deve açısından zengin kaynaklara sahip olmalarıyla ilgiliydi. Asur kralları Arabistan Yarımadası’ndaki çıkarlarını bazen askeri seferler ile bazen ise siyasi uzlaşma yoluyla korumaya çalışmıştır. Asur, gerçekleştirdiği askeri seferler ile Araplar üzerinde üstünlük kurmuş olmasına rağmen, bölgenin sahip olduğu coğrafi ve iklim şartları Asur’un bölgeye nüfuz etmesine engel olmuştur. Asur’un bölgeye gerçekleştirdiği seferler geniş çaplı yağma faaliyetlerinden öteye geçememiş, Asur ordusu geri çekilir çekilmez Arap kabileleri bağımsız bir şekilde davranmışlar ve ilk fırsatta Asur karşıtı hareketlerin içerisinde yer almışlardır. Asur kaynakları, Asur ve Arap krallıkları arasındaki askeri ve siyasi ilişkilerinin yanında, Arapların siyasi ekonomik ve sosyal hayatları hakkındaki önemli bilgileri barındırmaktadır. Asur yazılı belgeleri Arabistan tarihi hakkında bilgi veren ilk yazılı kaynak olma özelliği de taşımaktadır.
On Enforcing Restrictive Measures in the Form of Bail
Authors:   Tomsk Agricultural Institute, Branch of Novosibirsk State Agrarian University (Tomsk, Russian Federation), Uvarov Oleg N.
Published: September 2020

Regulatory legal acts do not provide for the court to change bail to a more stringent measure of restraint at the request of the investigator or interrogating officer, or during the trial at the penal inspectorate’s presentation in case the suspect or the accused violated the imposed bans or refused to use audiovisual, electronic and other technical means of control, deliberately damaged, corrupted or destroyed them. That is, the latest amendments and additions made to the criminal procedure law are of a declarative nature, and, in practice, no liability follows if a person under bail fails to comply with certain prohibitions and refuses to use electronic equipment for control. Such a person may ignore prohibitions and not allow the use of any electronic equipment on them. Damaging or destroying electronic technical means of control is not an issue for no liability follows either, and recovery of damage is carried out in accordance with the general civil procedure.
nf-vcf-cataloguer v1
Authors: Aguilar Ordoñez Israel
Published: September 2020

'nf-vcf-cataloguer' is a tool, implemented in Nextflow, that generates a general table description in TSV format of the description of each category and subgroup of a VCF with the extended annotation made by VEP. Furthermore, it plots each subset of the consequences of variants.
nf-100GMX-variant-summarizer v1
Authors: Aguilar Ordoñez Israel
Published: September 2020

Nextflow pipeline used to count variants for the 100GMX project 'nf-100GMX-variant-summarizer' is a pipeline tool that counts variants in a VEPextended annotated VCF file. This pipeline generates 3 outputs: 1) a TSV file with the total number of SNV and indels 2) a TSV file with per sample counts for variants of type SNV, indel, novel, worldwide singletons, clinvar, gwascat and pharmgkb 3) a PDF file with the number of discernible variants in sample groups of interest. Important note: input file must be previously annotated by https://github.com/Iaguilaror/nf-VEPextended
"Korean wave" in the dialectic of cultural development
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Grytsenko V.S.
Published: September 2020

The article covers the consideration of the "Korean Wave" as one of the manifestations of dialectical laws of culture development. The interpretation of the phenomenon only as a situational model of state cultural policy is refuted through the analysis as an incorrect and unreasonably narrowed understanding. We consider the "Korean Wave"as a variant of the cultural wave, which is a constant element in general processes of cultural development of mankind; we substantiate the grounds for its studying from the point of view of dialectical unity of internal and external factors. We show that the features of its formation and functioning determined by this way have expert ability in the analysis of the processes of culture creation, which are extremely accelerated today. In this connection, essential comprehension of the culture as living organism, caused by spiritual and generic motivations of a man and connected with his continuous self-development, displays its principality. In this sense, the "Korean Wave",a phenomenon of modern stage of culture development, shows itself as its regular stage, connected with its dynamicmorphological features. It displays an example of the cultural wave as a component of general cultural cyclicality, caused by permanent motionfraught with excitationand wavyoutbursts. Every such wave, having its historically specific motivation, is transparent regarding general mechanisms of cultural development. The absence of direct studies of culture dialectics, one component of which is shown by the phenomenon of the cultural wave, is the cause of dominating in modern culture studies of a descriptive factology principle. From the position of understanding the dialectics of general cultural movement, the appearance of a new one, the"Korean Wave"in this case, is a result of complicated multistage processes happening in the public culture body, where quantity is transformed into quality, trends into laws in response to spiritual needs of a man. It completely concerns the "Korean Wave"as well, as in collisions of its appearance, the complicated relations between the old and the new, tradition and situationality, closeness and openness, emotional and rational issues are involved.
G. E. Lessing's Laocoon: the potential of the semantic approach
Authors:   Kyiv Karpenko-Karyi National University of Theatre, Cinema and Television, Mylenka H. D.
Published: September 2020

Despite the large array of studies of the theoretical heritage of the German enlightener, this aspect has been most fully developed in the works of I.G. Gerder (article "Critical forests"), R. Ingarden (monograph "Research in aesthetics") and E. Basin (monograph "Art and communication"). In updating the potential of the semantic problematic of Laocoon, considerable assistance is provided by the recourse to studies in which the fruitfulness and relevance of this aspect of the Lessing tract is emphasized to one degree or another. There is an attempt to analyze, in one theoretical space, works on Lessing theory of signs. In order to identify the essence of the disagreement between I.G. Gerder and G.E. Lessing in the field of establishing boundaries between the kinds of art, special attention is paid to the consideration of Gerder concept of comparative analysis of painting, music and poetry, which is based on the difference of their ways of influence on the recipient – "in space", "in time "and" by force". In the process of analyzing Gerder's reflections, not only his critical attitude to the theory of signs developed by Lessing was considered, but also an attempt by the opponent of "Laokoon" author to justify the use of key concepts of metaphysics to compare the impact of different kinds of art. When comparing the views of E. Basin and R. Ingarden on the semantic aspect of "Laocoon", the debatable nature of their judgments about the characterization of the characters used in poetry by Lessing is identified. In addition, the article analyzes Lessing's thinking about the possibility of connecting different types of art, the organic combination of which depends on the specifics of the signs used by one or the other art, as well as emphasizes the productivity of the German thinker's idea. This aspect is revealed not only through the analysis of "Laokoon" in the works of E. Basin and R. Ingarden, but also by turning to the theoretical developments of E. Cassirer, B. Balash, A. Vartanova. Thus, the study of the semantic issues of Laokoon has shown the prominence of its conceptual landmarks for theoretical search, both in the field of aesthetics and art.
Değişken gecikmeli kısıtlı stokastik kontrol geçiş sistemleri için regülatör problemi
Authors: AĞAYEVA Çerkez
Published: September 2020

Bu makalede,
doğrusal stokastik denklemler sınıfıyla  
ifade olunan geçiş sistemleri ele alınmıştır. Gecikmeli faz ve kontrol
parametreleri içeren diferansiyel denklemler için karesel amaç fonksiyonu olan
optimal kontrol problemi oluşturulmuş ve sağ uç noktasında  kısıta sahip olan durum için  optimizasyon problemi incelenmiştir. Literatürde
Doğrusal Karesel Regülatör  olarak
bilinen ve sabit katsayılı stokastik diferansiyel denklemlerle ifade olunan bu
problemin optimal lığı için yeter ve gerek koşul, maksimum prensibi şeklinde  ispatlanmıştır. Bunun yanı sıra geçiş
sistemleri için önemli olan geçiş noktalarının bulunması için karşıtlık
koşulları  bulunmuştur. Sonda ise  Doğrusal Karesel Regülatör  problemleri için önem taşıyan optmal
kontrolün geri dönüşüm  şekli
bulunmuştur. Çözümü,   Rikkati
denklemleriyle  ifade olunan geri
dönüşüm  problemi, bu çalışmada   değişken gecikmeli stokastik sistemler için
uygulanmıştır.