Biomedical Application of Identified Biomarkers Gene Expression Based Early Diagnosis and Detection in Cervical Cancer with Modified Probabilistic Neural Network
Authors: Ramesh K. , Agarwal Pankaj , Ahuja Vandana , Mir Bilal Ahmed , Yuriy Shvets , Altuwairiqi Majid , Nuagah Stephen Jeswinde 
Published: September 2022

Cervical squamous cell carcinoma (CSC) is expected to rise to become the fourth most prevalent cancer in women globally and to replace breast cancer as the top cause of death in women in the future years, according to the World Health Organization. According to the World Health Organization, developing countries are responsible for 86 percent of all cervical cancer cases globally in women aged 15 to 44 (WHO). Cancer mortality is associated with the largest amount of monotonous antecedent in low‐ and middle‐income nations, while cancer mortality is associated with the least amount of monotonous antecedent in high‐income countries. Cervical cancer is thought to be caused by aberrant proliferation of cells in the cervix that is capable of stealing or invading other human organs, according to current thinking. Cancer of the cerebral cell is the most prevalent kind of cancer in women. It is expected that cervical squamous cell carcinoma (CSC) will be the fourth most frequent cancer in the world and the main cause of death in women by the year 2050. Despite the fact that technology has improved tremendously since then, this is still the case. When compared to high‐income countries, low‐ and middle‐income countries have the highest consistent antecedent for cancer mortality, according to the World Cancer Research Fund. Cancerous growths of cells in the cervix, such as cervical cancer, are caused by cells that have the ability to steal from or invade auxiliary organs of the body, as is the case with cervical cancer. Although technological advances have been made in recent years, gene expression profiling continues to be a prominent approach in the investigation of cervical cancer. Since then, researchers have had the opportunity to examine a gene coexpression network, which has evolved into an exceptionally comprehensive technique for microarray research. This has helped them to get a better understanding of the human genome. When a specific biological issue is addressed, gene coexpression networks retain a considerable percentage of their once vast component of physiognomy, which was previously immense. When comparing the properties of genes in a population, it is well known that feature selection may be used to choose genes that outperform the rest of the genes in the population. There are several benefits to feature selection, and this is only one of them. Typically used gene selection approaches have been shown to be insufficient in acquiring the best potential sequence of genes for training purposes, and as a result, the accuracy of the classifier has likely suffered as a result of this. Recently, a considerable number of scientists have advocated for the use of optimization approaches in the process of gene selection, and this trend is expected to continue. A metaheuristic algorithm may be used to choose a suitable subset of genes, according to the preceding assertion, which is also consistent with the metaheuristic approach. A Modified Probabilistic Neural Network differs from other networks in that the underlying gene expression associated with DEGs and standard data in a Modified Probabilistic Neural Network is not uniformly distributed as it is in other networks (MPN). As previously said, selecting the most relevant genes or repeating genes is a vital step in the prediction process. It was this technique that was used in the research of cervical cancer. Since then, researchers have had the opportunity to examine a gene coexpression network, which has evolved into an exceptionally comprehensive technique for microarray research. This has helped them to get a better understanding of the human genome. When a specific biological issue is addressed, gene coexpression networks are able to preserve a previously major section of the face that had been lost. When comparing the properties of genes in a population, it is well known that feature selection may be used to choose genes that outperform the rest of the genes in the population. There are several benefits to feature selection, and this is only one of them. Typically used gene selection approaches have been shown to be insufficient in acquiring the best potential sequence of genes for training purposes, and as a result, the accuracy of the classifier has likely suffered as a result of this. In the field of gene selection, several scholars have argued in favor of the employment of optimization approaches. A metaheuristic algorithm may be used to choose a suitable subset of genes, according to the preceding assertion, which is also consistent with the metaheuristic approach. It was discovered that Modified Probabilistic Neural Networks (MPNs) had a different distribution of gene expression linked with DEGs and normal data than other networks, which had not been previously seen. This was previously unknown. Following what has been said before, selecting the most appropriate or repeated genes is a critical task throughout the prediction process.