bluuebunny/crossref_metadata_2025 huggingface dataset:
An evaluation of dermal microcirculatory occlusion under repeated mechanical loads: Implication of lymphatic impairment in pressure ulcers
Authors: Worsley Peter R. , Crielaard Hanneke. , Oomens Cees W. J. , Bader Dan L.
Published: June 2020

Objective

Pressure ulcers are caused by prolonged mechanical loads deforming the underlying soft tissues. However, the mechanical loads for microcirculatory occlusion are unknown. The present study was designed to characterize the simultaneous response of microvascular and lymphatic structures under repeated mechanical loading.

Methods

The effects of two distinct loading/unloading cycles involving (a) incremental pressures 30, 60, and 90 mmHg and (b) three repeated cycles of 30 mmHg were evaluated on a cohort of able‐bodied volunteers. Microvascular response involved the monitoring of transcutaneous gas tensions, while dermal lymphatic activity was estimated from near‐infrared imaging. Responses were compared during each load and recovery cycle.

Results

Changes in microvascular response were dependent on the load magnitudes, with 30 mmHg resulting in a reduction in oxygen tension only, while 90 mmHg affected both oxygen and carbon dioxide values in most cases (54%). By contrast, lymphatics revealed near total occlusion at 30 mmHg. Although there were intersubject differences, temporal trends consistently revealed partial or full impairment under load, with recovery during off‐loading.

Conclusions

The pressure required to cause microcirculatory occlusion differed between individuals, with lymphatic impairment occurring at a lower pressure to that of microvascular vessels. This highlights the need for personalized care strategies and regular off‐loading of vulnerable tissues.
Why, and to What Extent, Is Sexual Infidelity Wrong?
Authors: McKeever Natasha
Published: June 2020

Sexual infidelity is widespread, but it is also widely condemned, yet relatively little philosophical work has been done on what makes it wrong and how wrong it is. In this paper, I argue that sexual infidelity is wrong if it involves breaking a commitment to be sexually exclusive, which has special significance in the relationship. However, it is not necessarily worse than other kinds of infidelity, and the context in which it takes place ought to be considered. I finish the paper by looking at how the hegemonic norm of monogamy makes infidelity both more likely and more difficult to deal with.
Maternal persistent marijuana use and cigarette smoking are independently associated with shorter gestational age
Authors: Nawa Nobutoshi , Garrison‐Desany Henri M. , Kim Yoona , Ji Yuelong , Hong Xiumei , Wang Guoying , Pearson Colleen , Zuckerman Barry S. , Wang Xiaobin , Surkan Pamela J.
Published: June 2020

Background

Research assessing the effects of marijuana use on preterm birth has found mixed results, in part, due to lack of attention to the role of maternal tobacco smoking during pregnancy.

Objectives

The study objective was to investigate whether maternal marijuana use was independently associated with gestational age, preterm birth, and two preterm birth subtypes (spontaneous vs clinician‐initiated).

Methods

Participants included 8261 mother‐newborn pairs from the Boston Birth Cohort. Information on gestational age was collected from electronic medical records. Marijuana use and tobacco smoking during pregnancy were assessed through a standard questionnaire after birth. Linear and log‐linear regression models were used to assess associations between marijuana use with and without tobacco smoking during pregnancy and the outcomes of interest.

Results

Of the 8261 mothers, 27.5% had preterm births. About 3.5% of mothers with term deliveries and 5.2% of mothers with preterm births used marijuana during pregnancy. Marijuana use and cigarette smoking were independently associated with a decrease in gestational age by 0.50 weeks (95% confidence interval [CI] −0.87, −0.13) and 0.52 weeks (95% CI −0.76, −0.28), respectively. Marijuana use during early or late pregnancy was associated with a similar decrease in gestational age by 0.50 weeks. When we examined the effects on the preterm birth subtypes, simultaneous marijuana use and tobacco smoking were associated with higher risk of spontaneous preterm birth (RR 1.64, 95% CI 1.23, 2.18). The elevated risk was not observed with clinician‐initiated preterm birth.

Conclusions

In this high‐risk US population, maternal marijuana use and cigarette smoking during pregnancy were independently associated with shorter gestational age. When we examined the effects on preterm birth subtypes, the elevated risk was only observed with spontaneous preterm birth.
Reviewer Acknowledgements
Authors: Gibbs Nikki
Published: June 2020

Applied Economics and Finance (AEF) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether AEF publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 7, Number 4 Ali Massoud, Sohag University, EgyptGetamesay Bekele Meshesha, Debre Berhan University, EthiopiaHedieh Shadmani, Fairfield University, USAHichem Maraghni, University of Taibah, TunisiaIan McFarlane, University of Reading, UKIgor Matyushenko, School of Foreign Economic Relations and Touristic Business, UkraineMagdalena Zioło, University of Szczecin, PolandMahmoud Mohammed Sabra, Al Azhar University-Gaza, PalestineMarco Muscettola, Independent Researcher-Credit Risk Manager, ItalyRajeev Rana, APB Govt. P.G. College, IndiaRamona Orastean, Lucian Blaga University of Sibiu, RomaniaRichard Nguyen, Alliant International University, USARomeo Victor Ionescu, Dunarea de Jos University, RomaniaShahram Fattahi, Razi University, IranSzabolcs Blazsek, Universidad Francisco Marroquín, GuatemalaVictoria Cociug, Academy of Sciences of Moldova, MoldovaZi-Yi Guo, Wells Fargo Bank, N.A., USA    Nikki GibbsEditorial AssistantOn behalf of,The Editorial Board of Applied Economics and FinanceRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://aef.redfame.com
Justicia restaurativa y reparación: desafíos de la JEP frente a una relación en construcción
Authors: Acosta-López Juana , Espitia Murcia Cindy Vanessa
Published: June 2020

La justicia restaurativa constituye un paradigma orientador de todo el Sistema Integral de Verdad, Justicia, Reparación y No Repetición. En la Jurisdicción Especial para la Paz, el principio no sólo irradia las sanciones propias y la condicionalidad, sino que cada etapa del procedimiento debe guardar estricta coherencia con tal paradigma y con sus fines: la reparación de las víctimas, la reconciliación y la reconstrucción del tejido social. Sin embargo, y a pesar de su importancia, aún existen importantes vacíos sobre el alcance del principio y sobre su relación con los demás componentes del modelo de justicia transicional. En este sentido, en el presente artículo de reflexión, se efectúa una revisión del concepto de justicia restaurativa y de su relación con otros componentes, especialmente el de reparación, desde una perspectiva analítica y propositiva. Asimismo, se plantean los retos de Colombia respecto de la materialización del principio, especialmente para la JEP. Las propuestas de las autoras, lejos de constituir fórmulas mágicas, plantean discusiones y debates que deben ser abordados, para lograr que este paradigma orientador contribuya a la construcción de paz en Colombia.
Participación colectiva de víctimas ante la jurisdicción especial para la paz (JEP)
Authors: Vargas Trujillo Juliette
Published: June 2020

Uno de los grandes desafíos que debe afrontar la Jurisdicción Especial para la Paz (JEP) para asegurar una participación real y significativa de las víctimas es implementar mecanismos idóneos de participación colectiva. Si bien la JEP ya ha establecido la participación colectiva a través de representante legal común como mecanismo para asegurar la participación amplia de víctimas, aún no se han concretado los parámetros que definen cómo debe operar. Con base en las dificultades y críticas que han surgido de algunas experiencias en el contexto de Justicia y Paz en Colombia y de escenarios internacionales como la Corte Penal Internacional, el objetivo de este artículo es visibilizar algunos aspectos y lecciones aprendidas notables que se pueden tener en cuenta para formular e implementar medidas acertadas al respecto. Este estudio plantea que la participación colectiva a través de representante legal puede fácilmente convertirse en una participación meramente simbólica a partir de factores como la homogenización de las víctimas, la ausencia de comunicación entre éstas y sus representantes, y la no concesión de un mínimo de incidencia en la escogencia de su representante y en los criterios de agrupación.
Design of a Novel Head Support for People With Hypermobile-Type Ehlers–Danlos Syndrome
Authors: Pierce Robert S. , Tanaka Martin L. , Ireton Candace , Church Zachary , Hudson David
Published: June 2020

Hypermobile-type Ehlers–Danlos Syndrome (hEDS) is characterized by connective tissue laxity resulting in excessive joint mobility. This can lead to instability of the cervical spine resulting in spinal cord compression and neck pain. People with hEDS often utilize commercially available cervical collars to provide head support, but these devices are not well-suited for this population. This work describes the development of a novel head support designed specifically to meet the needs of people with hEDS. The head support was developed using the principles of human-centered design, in which the end user is an active participant in the design process. People with hEDS were interviewed to identify limitations of existing support devices and desirable features of a new device. Input from the interviews was combined with structured design methods to generate initial designs. A prototype of a selected initial design was developed and evaluated by a person with hEDS. Feedback from this evaluation was incorporated into a second-generation design. This improved design stabilizes and supports the head while flexing to allow limited motion. It has an open, well-ventilated structure, and can be worn under clothes. By including end users in the design process, making effective use of computer-aided design and additive manufacturing processes, and gaining feedback through rapid prototyping, the product development process has been accelerated and focused on the needs of the end-user. Future work will continue to include people with hEDS as part of the design team to develop a high-functioning, affordable head support.
On the Reliability of Suction Measurements for Skin Characterization
Authors: Mueller Bettina , Elrod Julia , Distler Oliver , Schiestl Clemens , Mazza Edoardo
Published: June 2020

in vivo skin characterization methods were shown to be useful in the detection of microstructural alterations of the dermis due to skin diseases. Specifically, the diagnostic potential of skin suction has been widely explored, yet measurement uncertainties prevented so far its application in clinical assessment. In this work, we analyze specific factors influencing the reliability of suction measurements. We recently proposed a novel suction device, called Nimble, addressing the limitations of existing instruments, and applied it in clinical trials quantifying mechanical differences between healthy skin and scars. Measurements were performed with the commercial device Cutometer and with the new device. A set of new suction measurements was carried out on scar tissue and healthy skin, and FE-based inverse analysis was applied to determine corresponding parameters of a hyperelastic-viscoelastic material model. FE simulations were used to rationalize differences between suction protocols and to analyze specific factors influencing the measurement procedure. Tissue stiffness obtained from Cutometer measurements was significantly higher compared to the one from Nimble measurements, which was shown to be associated with the higher deformation levels in the Cutometer and the nonlinear mechanical response of skin. The effect of the contact force exerted on skin during suction measurements was quantified, along with an analysis of the effectiveness of a corresponding correction procedure. Parametric studies demonstrated the inherently higher sensitivity of displacement- over load-controlled suction measurements, thus rationalizing the superior ability of the Nimble to distinguish between tissues.
A new genus and species of larval Trombellidae ectoparasitic on moths from Iran

Authors: Noei Javad , Rabieh Mohammad Mahdi
Published: June 2020

Birjandtrombella farniae Noei gen. et sp. nov. (Acari: Trombidiformes: Prostigmata: Trombellidae) is described and illustrated from larvae ectoparasitic on moths (Lepidoptera: Crambidae, Noctuidae, Pyralidae), from Birjand city, South Khorasan province, Iran. Moth families Crambidae and Pyralidae are recorded as the host of Trombellidae larvae, for the first time. Also, a key to genera of Trombellinae Thor, 1935 of the world (larva) is presented.
Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus
Authors: Busse D. C. , Habgood-Coote D. , Clare S. , Brandt C. , Bassano I. , Kaforou M. , Herberg J. , Levin M. , Eléouët J.-F. , Kellam P. , Tregoning J. S.
Published: June 2020

RSV infects all children under 2 years of age, but only a subset of children get severe disease. We hypothesize that susceptibility to severe RSV necessitating hospitalization in children without predefined risk factors is, in part, mediated at the antiviral gene level. However, there is a large array of antiviral genes, particularly in the ISG family, the mechanism of which is poorly understood. Having previously identified IFI44 and IFI44L as possible genes of interest in a bioinformatic screen, we dissected the function of these two genes in the control of RSV. Through a range of overexpression and knockout studies, we show that the genes are antiviral and antiproliferative. This study is important because IFI44 and IFI44L are upregulated after a wide range of viral infections, and IFI44L can serve as a diagnostic biomarker of viral infection.
Cardiac tamponade after superior vena cava stenting
Authors: Bongers Kale S , Patel Vaiibhav , Gualano Sarah K , Schildhouse Richard J
Published: June 2020

Superior vena cava (SVC) syndrome results from the blockage of venous blood flow through the SVC, which is caused by either internal obstruction (eg, thrombus) or external compression (eg, thoracic malignancy and infection).1 While thrombus-related SVC syndrome is rising in prevalence, malignancy still accounts for the majority of cases.1 Regardless of cause, SVC syndrome is characterised by facial swelling and plethora, headache and dyspnoea.2 Although venous stenting has become standard of care for treatment of acute SVC syndrome, stent placement presents multiple risks including SVC rupture and cardiac tamponade. In these cases, a high index of suspicion and prompt action are required to avoid an often fatal outcome. Here, we present the case of a patient with cardiac tamponade and subsequent cardiac arrest after SVC stent placement.
Examining the added value of microperimetry and low luminance deficit for
predicting progression in age-related macular degeneration
Authors: Wu Zhichao , Luu Chi D , Hodgson Lauren AB , Caruso Emily , Chen Fred K , Chakravarthy Usha , Arnold Jennifer J , Heriot Wilson J , Runciman Jim , Guymer Robyn H
Published: June 2020

Purpose

To examine the added predictive value of microperimetric sensitivity and
low luminance deficit (LLD; difference between photopic and low luminance
visual acuity (VA)) to information from colour fundus photography (CFP) for
progression to late age-related macular degeneration (AMD) in individuals with
bilateral large drusen.

Methods

140 participants with bilateral large drusen underwent baseline
microperimetry testing, VA measurements and CFP. They were then reviewed at
6-monthly intervals to 36 months, to determine late AMD progression.
Microperimetry pointwise sensitivity SD (PSD), LLD and the presence of
pigmentary abnormalities on CFPs were determined. Predictive models based on
these parameters were developed and examined.

Results

Baseline microperimetry PSD and presence of pigmentary abnormalities were
both significantly associated with time to develop late AMD (p≤0.004), but LLD
was not (p=0.471). The area under the receiver operating characteristic curve
(AUC) for discriminating between eyes that progressed to late AMD based on
models using microperimetry PSD (AUC=0.68) and LLD (AUC=0.58) alone was
significantly lower than that based on CFP grading for the presence of
pigmentary abnormalities (AUC=0.80; both p<0.005). Addition of
microperimetry and/or LLD information to a model that included CFP grading did
not result in any improvement in its predictive performance (AUC=0.80 for all;
all p≥0.66).

Conclusions

While microperimetry, but not LLD, was significantly and independently
associated with AMD progression at the population level, this study observed
that both measures were suboptimal at predicting progression at the individual
level when compared to conventional CFP grading and their addition to the
latter did not improve predictive performance.
Occupational radiation exposure and morbidity of circulatory disease among diagnostic medical radiation workers in South Korea
Authors: Cha Eun Shil , Zablotska Lydia B , Bang Ye Jin , Lee Won Jin
Published: June 2020

Objectives

We investigated the association between low-dose external occupational radiation exposure and circulatory disease morbidity among diagnostic medical radiation workers.

Methods

A cohort of 11 500 diagnostic medical radiation workers was linked with the National Dosimetry Registry data and the National Health Insurance Service data. Relative risks (RRs) were calculated to explore the association between occupational factors and circulatory disease morbidity, and excess relative risks per 100 milligray (ERR/100 mGy) were estimated to quantify the radiation dose-response relationship.

Results

Overall, there were 2270 cases of circulatory diseases during 93 696 person-years of observation (average follow-up=8.1 years). RRs for hypertension were significantly increased for individuals who started working before 2000 compared with those who started in 2005 and later. ERR/100 mGy for all circulatory diseases was 0.14 (95% CI −0.57 to 0.99). Radiation risks of cerebrovascular diseases and ischaemic heart disease were non-significantly increased with estimates of individual cumulative doses to the heart (ERR/100 mGy=3.10 (−0.75 to 11.59) and 1.22 (−0.71 to 4.73), respectively). However, ERR estimates were generally more strongly positive for female versus male workers and for younger workers versus more than 50-year-old workers.

Conclusions

This study provides little evidence in support of a positive association between occupational radiation exposure and the overall risk of circulatory disease over a short follow-up period among medical radiation workers in South Korea. However, significantly increased RR with earlier year first worked, elevated ERR in female workers and young workers should be further followed up.
CEACAM3decreases asthma exacerbations and modulates respiratory syncytial virus latent infection in children
Authors: Tsai Ching-Hui , Wu Ann Chen , Chiang Bor-Luen , Yang Yao-Hsu , Hung Shih-Pin , Su Ming-Wei , Chang Ya-Jen , Lee Yungling L
Published: June 2020

Background

Respiratory syncytial virus (RSV) is associated with childhood asthma. Nevertheless, not all children exposed to RSV develop asthma symptoms, possibly because genes modulate the effects of RSV on asthma exacerbations.

Objective

The purpose of this study was to identify genes that modulate the effect of RSV latent infection on asthma exacerbations.

Methods

We performed a meta-analysis to investigate differentially expressed genes (DEGs) of RSV infection from Gene Expression Omnibus datasets. Expression quantitative trait loci (eQTL) methods were applied to select single nucleotide polymorphisms (SNPs) that were associated with DEGs. Gene-based analysis was used to identify SNPs that were significantly associated with asthma exacerbations in the Taiwanese Consortium of Childhood Asthma Study (TCCAS), and validation was attempted in an independent cohort, the Childhood Asthma Management Program (CAMP). Gene–RSV interaction analyses were performed to investigate the association between the interaction of SNPs and RSV latent infection on asthma exacerbations.

Results

A total of 352 significant DEGs were found by meta-analysis of RSV-related genes. We used 38 123 SNPs related to DEGs to investigate the genetic main effects on asthma exacerbations. We found that eight RSV-related genes (GADD45A, GYPB, MS4A3, NFE2, RNASE3, EPB41L3, CEACAM6andCEACAM3) were significantly associated with asthma exacerbations in TCCAS and also validated in CAMP. In TCCAS, rs7251960 (CEACAM3) significantly modulated the effect of RSV latent infection on asthma exacerbations (false-discovery rate <0.05). The rs7251960 variant was associated withCEACAM3mRNA expression in lung tissue (p for trend=1.2×10−7).CEACAM3mRNA was reduced in nasal mucosa from subjects with asthma exacerbations in two independent datasets.

Conclusions

rs7251960 is an eQTL forCEACAM3, andCEACAM3mRNA expression is reduced in subjects experiencing asthma exacerbations.CEACAM3may be a modulator of RSV latent infection on asthma exacerbations.
Impact of the Suissano Health Programme on antimicrobial usage on 291 pig farms in Switzerland
Authors: Echtermann Thomas , Müntener Cedric , Sidler Xaver , Kümmerlen Dolf
Published: June 2020

Background

In 2015, in Switzerland the Suissano Health Programme was implemented in pig production to improve transparency for antimicrobial usage (AMU) and to reduce the usage of fluoroquinolones (FQ), macrolides and cephalosporins, representing highest priority critically important antimicrobials.

Methods

In the presented cohort study, the impact of the Suissano programme on the AMU of 291 pig farms between 2016 and 2017 was investigated. AMU was calculated in total numbers of defined course doses (nDCDch) for all farms in the programme. For each single farm the nDCDch/animal/year was determined for four different age categories (suckling piglets, weaned piglets, fattening pigs, sows) as well as each antimicrobial substance separately. Trends between 2016 and 2017 were investigated for all farms as well as the 25 per cent with the highest usage of antimicrobials (high users) separately.

Results

Total AMU measured in nDCDch declined by 23 per cent between 2016 and 2017, but statistically significant differences could not be observed when comparing the data sets of the individual farms. A significantly reduced usage of FQ could be demonstrated in suckling piglets (P=0.003), weaned piglets (P=0.006) and sows (P=0.008) in 2017 compared with 2016. For high users, a significant reduction of total AMU could be shown in suckling piglets (P=0.02), weaned piglets (P=0.0004) and fattening pigs (P=0.01).

Conclusion

This study demonstrated a significant reduction in the usage of FQs in suckling piglets, weaned piglets and sows as well as total AMU in suckling piglets, weaned piglets and fattening pigs on high‐usage farms.
Evolution of dark energy perturbations for Slotheon field and power spectrum
Authors: Mukhopadhyay Upala , Majumdar Debasish , Adak Debabrata
Published: June 2020

Within the framework of modified gravity model namely Slotheon model, inspired by the theory of extra dimensions, we explore the behaviour of Dark Energy and the perturbations thereof. The Dark Energy and matter perturbations equations are then derived and solved numerically by defining certain dimensionless variables and properly chosen initial conditions. The results are compared with those for standard quintessence model and $$\varLambda $$ΛCDM model. The matter power spectrum is obtained and also compared with that for $$\varLambda $$ΛCDM model. It appears that Dark Energy in Slotheon model is more akin to that for $$\varLambda $$ΛCDM model than the standard quintessence model.
CORPORATE SOCIAL RESPONSIBILITY DISCLOSURE, MEDIA COVERAGE AND FINANCIAL PERFORMANCE: AN EMPIRICAL ANALYSIS IN THE CHINESE CONTEXT
Authors: WANG LU , LI YANXI , LI XIAOCHONG
Published: June 2020

Incorporating instrumental views of corporate social responsibility (CSR), this paper analyzes CSR in the Chinese context to reveal the media-based mechanism, which clarifies how corporate social responsibility disclosure (CSRD) generates shareholder value. Our results show that firms with better CSRD attract more attention in the media, and high CSRD is positively related to corporate financial performance (CFP), partially mediated by the media coverage. With further investigation, we find that the mediating effect of media coverage is significant only in customer-sensitive industries. This study implies that the strategic use of CSRD to create economic benefits for firms may be of value to managers and investors who desire to understand the effect of CSR and media coverage on firm financial performance.
The Broken Symmetry of Output Currents in a Matrix Converter and Its Recovery Control
Authors: Sánchez Manuel , Okuda Takafumi , Hikihara Takashi
Published: June 2020

Symmetry is not only used to simplify the analysis of three-phase electrical systems, but it is also used to define its voltages, currents and loads. When the loads are symmetrical, the currents of a three-phase AC system are expected to be symmetrical as well. Given the proper conditions, in converters such as the matrix converter (MC), the output voltages and currents are expected to be sinusoidal with periodic symmetry. However, in some cases this symmetry is broken so that, there appears nonlinear behaviors such as quasiperiodicity and so on. Based on simulations and experiments, this paper focuses on an analysis of a quasiperiodic behavior and the presence of a DC component in the output currents of a Venturini modulated MC. The presence of such behaviors in the output currents indicates that the symmetry in a period is broken. The broken symmetries appear when the input and output frequencies are mismatched. In addition, this paper shows the possibility to recover the symmetry of the output currents of the MC. The method for symmetry recovery is based on a time-delayed feedback control. The simulation and experimental results indicate the possibility of attenuating the quasiperiodic behavior and DC component.
A Graph-Based Tag Recommendation for Just Abstracted Scientific Articles Tagging
Authors: Boughareb Djalila , Khobizi Abdennour , Boughareb Rima , Farah Nadir , Seridi Hamid
Published: June 2020

Tags, when properly assigned to limited access papers, help users to estimate their relevance. This paper introduces a new approach for the selection of relevant tags as well as a recommendation for scientific papers tagging. The approach defines the relatedness between the tags attributed by users and the concepts extracted from the available sections of scientific papers based on statistical, structural and semantic aspects. Two different term-based graphs ([Formula: see text]-graph and [Formula: see text]-graph) were generated whose vertices indicate the terms and the edges represent the relatedness score between these terms. In addition, two algorithms were implemented to select and recommend the relevant tags: the neighbor-algorithm and the best-path-algorithm. The results of the experiments performed on a CiteULike collection of tagged papers show significant improvements only for the tagging of abstracted scientific articles. The approach was evaluated by referring to the full text of the papers with expert evaluation and comparing the tags generated by CiteULike users. Using the neighbor-algorithm, 80% of the top 10 recommended tags based on [Formula: see text]-graph and 76% of the top 10 recommended tags based on the [Formula: see text]-graph were relevant. While only 62% of those recommended by CiteULike users were relevant. The best-path-algorithm gave the best results in the top 20 and top 30 recommended tags and this in comparison with the tags recommended by the neighbor-algorithm and the tags assigned by CiteULike users.
The Role of Mapping Curve in Swarm-Like Opinion Formation
Authors: Gwizdałła Tomasz M.
Published: June 2020

Recently, [T. M. Gwizdałła, The swarm-like update scheme for opinion formation, in Computational Collective Intelligence, eds. N. T. Nguyen, G. A. Papadopoulos, P. Jedrzejowciz, B. Trawinski and G. Vossen (Springer International Publishing, Cham, 2017), pp. 66–75.] we have proposed the scheme of performing the opinion formation simulation based on popular global optimization mechanism — the Particle Swarm Optimization (PSO). The basic idea was to use the interaction between two potential directions of agents’ heading: those forced by the global opinion and those forced by the opinion of neighbors/colleagues. In the proposed paper, some enhancement of the proposed model is shown. We assume that, when performing the binary PSO-like update of system, we use the generalized version of logistic function. The results are promising in the sense that the introduced change increases explicitly, the number of possible solutions.
THE SOLAR-TERRESTRIAL RELATIONSHIP USING FRACTAL DIMENSION
Authors: HASSAN DANISH , AKHTER MUHAMMAD FAHIM , ABBAS SHAHEEN
Published: June 2020

Sun is the main source of energy for the earth and other planets. Its activity in one or other way influences the terrestrial climate. Particularly, the solar activity manifested in the form of sunspots is found to be much more influential on the earth’s climate and on its magnetosphere. Links of the variability in terrestrial climate and sunspot cycles and associated magnetic cycles have been the concern of many recent studies. These two time series data sunspots and K-index are distributed into 22-year cycles, according to the magnetic field of the sun in which polarity reverses after 11-years. The fractal dimension of each sunspot cycle from 1 to 24 is calculated and found to be quasi-regular (persistent, [Formula: see text]). To understand the regular effects of the dynamics of sunspot cycles on the earth’s climate and magnetosphere, the sunspot cycles and K-index cycles (22 years each) from 1932 to 2014 are observed and discussed comparatively in the perspective of fractal dimension and Hurst exponent.
A Rare Case of Light Chain Amyloidosis of the Gastrointestinal Tract
Authors: Dvir Kathrin , Galarza-Fortuna Gliceida M. , Willet Anna , Febres-Aldana Christopher , Cortez Nathaly , Rapaka Samuel , Coombs Andre , Goldberg Robert , Schwartz Michael , Ben-David Kfir
Published: June 2020

A 65-year-old Hispanic female presented with a one-year history of anorexia, nausea, early satiety, epigastric discomfort, and a 20 kg weight loss. Computed tomography (CT) demonstrated heterogeneous liver parenchyma. Upper endoscopy revealed large, fungating, infiltrative mass at the lesser gastric curvature incisura, highly suspicious of gastric tumor; however, initial biopsy of the gastric mass was equivocal and an exploratory laparoscopy was performed. Repeated intraoperative biopsies of the gastric mass and of liver parenchyma demonstrated diffuse hyalinized stroma consistent with amyloid deposition, and a bone marrow biopsy confirmed the diagnosis of primary light chain (AL) amyloidosis.
Authentication and Secrecy of Multicast Communication Scenario: Artificial Noise-Aided Costas Sequence Matrix FDA Approach
Authors: Nusenu Shaddrack Yaw
Published: June 2020

In multicast communication scenario, the desired users are decomposed into M groups to receive private M useful data from the transmitter, while eavesdroppers (Eves) group tries to intercept. Since wireless security system consists of authentication and secure transmission, we propose directional modulation (DM) artificial noise (AN) matrix-aided Costas sequence (CS) matrix frequency diverse array (FDA) in multicast precoding systems in this paper. Specifically, we utilize the CS matrix for desired groups authentication (i.e., group identity), and it is shared via a low-speed forward link in advance. Next, we design AN matrix-aided FDA to offer robust antieavesdropping method based on leakage concept. Furthermore, we devise secrecy metrics, namely, secrecy outage probability (SOP), asymptotic Eve’s detectability error probability, and average useful data leakage rate, based on the scenario where Eve’s instantaneous channel state information (CSI) is unavailable. In addition, we numerically analyze the proposed energy beamforming focusing and evaluate the secrecy energy efficiency. Via simulation results, the proposed scheme gives important insights into how to design and measure secrecy performances in multicast scenarios.
Unilateral Nonconfluent Cluster of Micronodules: Atypical Radiologic Appearance of Pulmonary Tuberculosis in an Immunocompetent Patient
Authors: Johari Bushra , Hanafiah Mohammad
Published: June 2020

Active pulmonary tuberculosis involving the lung parenchyma is typically seen on CT as consolidation, centrilobular nodules with tree-in-bud branching, cavitating lesions, and miliary nodules. However, some atypical CT patterns of granulomatous disease including tuberculosis have been recently described, namely, clusters of nodules without confluence or with confluence. We present a case of a patient who was found to have nonconfluent clusters of micronodules in the right lung with negative sputum culture for tuberculosis. There were also incidental findings of the partial duplex system of the left kidney with mild-to-moderate hydronephrosis in the lower moiety with proximal hydroureter. The urine culture was then positive for mycobacterium tuberculosis; hence, he was commenced on antituberculous medications. A repeated CT scan revealed significant improvement of the aforementioned clusters of micronodules and left hydronephrosis. In the present case, we would like to highlight the atypical appearances of pulmonary tuberculosis in the form of nonconfluent micronodules on HRCT despite negative sputum workup, with the concurrent active genitourinary tuberculosis.
Chemical Composition and Antioxidant Capacity of Lepidium sativum Seeds from Four Regions of Morocco
Authors: Chatoui Khalid , Harhar Hicham , El Kamli Taha , Tabyaoui Mohamed
Published: June 2020

Lepidium sativum seeds (LSS) from four regions of Morocco have been analyzed for their total chemical composition and antioxidant activities. In the seeds of this plant, the moisture content and yield were, respectively, 9.24–9.88% and 19.13–19.94% of dry weight. Chemical analysis of the seeds revealed amounts of fatty acids, sterols, and tocopherols. The most important fatty acids are linolenic acid (33%) and oleic acid (23%). The main sterol is β‐sitosterol (50%); the vegetable oil of Lepidium sativum revealed an amount of tocopherol (∼1500–1900 mg/kg) with dominance of γ‐tocopherol. The Folin–Ciocalteu trial evaluated the total phenolic compound, DPPH radical scavenging, ABTS, and chelated iron ions. FRAP measured antioxidant potency. Results indicated that methanol extract from Lepidium sativum was a more potent reducing agent and radical scavenger than ethanol extract. Changes in the total phenolic content and antioxidant capacity of Lepidium sativum in four different regions grown under normal conditions were evaluated. The antioxidant activity of different extracts was found to correlate significantly with their total phenolic content. These results suggest that Lepidium sativum seeds could be used in food supplement preparations or as a food additive, for caloric gain or for protecting against oxidation in nutrient products.
Impact of the Adjustment of Maximum Order Volume on Pricing Efficiency of Stock Index Futures in China
Authors: Wang Liang , Xu Tingjia , Qin Longhao , Xiong Xianyan
Published: June 2020

In April 2017, China Financial Futures Exchange adjusted the maximum order volume of single trading in stock index futures, and this paper conducts research on this event. Firstly, it analyzes the influence of the adjustment of maximum order volume on the characteristics of the limit order book with high-frequency data and the impact of ordering situation on the trading depth and volatility of each contract with panel data. Secondly, it takes high-frequency tick-by-tick data to explore the causal relationship between the ordering situation and the probability of informed trading and analyzes the impact of the event on the probability of informed trading. Finally, the dynamic factor analysis method is used to quantify the pricing efficiency based on the probability of informed trading and the characteristics of limit order book, and the influence of the event on the pricing efficiency of stock index futures market is discussed. The results show that the reduction of maximum order volume has different effects on dominant contracts and nondominant contracts of stock index futures. After the event, the overall trading volume of the market increased, where the trading volume of dominant contracts decreased and that of nondominant contracts increased. For dominant contracts, the depth, slope, and liquidity decrease, the spread increases, and the probability of informed trading decreases so that the pricing efficiency becomes worse, while the results of nondominant contracts are the opposite. For Chinese stock index futures market, the pricing efficiency is greatly reduced and the resource allocation capacity is weakened under the influence of the event. Therefore, the adjustment of maximum order volume is not conducive to the healthy development of the stock index futures market. It is suggested that the reduction of the maximum order volume is only implemented for nondominant contracts.
The Presentation and Treatment Response of Catatonia in Patients Admitted to the Psychiatric Inpatient Unit at Jimma University Medical Center, Ethiopia
Authors: Yitayih Yimenu , Tesfaye Elias , Adorjan Kristina
Published: June 2020

Background. Catatonia is among the most mysterious and poorly understood neuropsychiatric syndrome. It is underresearched and virtually forgotten but still a frequent neuropsychiatric phenotype in both developed and low-income countries. Catatonia is associated with a number of medical complications like pulmonary embolism, dehydration, or pneumonia if it is not treated and managed adequately. In Ethiopia, however, almost no studies are available to describe the symptoms and the response to treatment in patients with catatonia. The aim of this retrospective study was therefore to describe the symptom profile of catatonia and to evaluate the treatment and outcome of catatonia in patients admitted to the psychiatric inpatient unit at Jimma University, Ethiopia. Method. Detailed treatment records of all inpatients were reviewed for the period from May 2018 to April 2019. All patients with catatonia at the inpatient unit of Jimma University Medical Center were assessed with the Bush-Francis Catatonia Rating Scale (BFCRS), and all comorbid psychiatric diagnoses were made according to the criteria of the Diagnostic Statistical Manual V. The presence and severity of catatonia were assessed by using the BFCRS at baseline and at discharge from the hospital. Result. In the course of one year, a total of 18 patients with the diagnosis of catatonia were admitted. The mean age of the participants was 22.8 years (SD 5.0; range: 15 to 34 years). The most common diagnosis associated with catatonia was schizophrenia (n=12; 66.7%), followed by severe depressive disorders (n=4; 22.2%). Mutism, posture, and withdrawal were registered in all patients (n=18, 100%). All patients received an injection of diazepam and had improved at discharge. Conclusion. Our study provides further evidence that catatonia is most commonly associated with schizophrenia, followed by major depressive disorder, and that mutism, posturing, and withdrawal are the most common signs and symptoms of catatonia.
The Expressions and Mechanisms of Sarcomeric Proteins in Cancers
Authors: Yang Xiaojing , Ren Hanru , Guo Xiaomao , Hu Chaosu , Fu Jie
Published: June 2020

The sarcomeric proteins control the movement of cells in diverse species, whereas the deregulation can induce tumours in model organisms and occurs in human carcinomas. Sarcomeric proteins are recognized as oncogene and related to tumor cell metastasis. Recent insights into their expressions and functions have led to new cancer therapeutic opportunities. In this review, we appraise the evidence for the sarcomeric proteins as cancer genes and discuss cancer-relevant biological functions, potential mechanisms by which sarcomeric proteins activity is altered in cancer.
Impact of Body Position on Lung Deposition of Nebulized Surfactant in Newborn Piglets on Nasal Continuous Positive Airway Pressure
Authors: Cunha-Goncalves Doris , Nord Anders , Bianco Federico , Salomone Fabrizio , Ricci Francesca , Schlun Martin , Linner Rikard , Perez-de-Sa Valeria
Published: June 2020

Introduction: The ideal body position during surfactant nebulization is not known. Objective: The aim of this study was to determine whether body positioning during surfactant nebulization influences surfactant distribution and deposition in the lungs. Methods: Twenty-four 12- to 36-h-old full-termpiglets (1.3–2.2 kg) on nasal continuous positive airway pressure (nCPAP) were randomized into four groups: lateral decubitus with right or left side up, prone or supine positions (n = 6 each). All animals received 200 mg kg–1 of poractant alfa mixed with 200 MBq of 99mtechnetium-nanocolloid via a customized eFlow-Neos investigational vibrating-membrane nebulizer. Surfactant deposition (percentage of the administered dose) was measured by gamma scintigraphy. Results: Comparing all groups, the mean total lung surfactant deposition was significantly higher in the prone position (32.4 ± 7.7%, p = 0.03). The deposition in this group was higher in the right lung (21.0 ± 8.6 vs. 11.3 ± 5.7%, p = 0.04). When nebulization was performed in the lateral decubitus, most of the surfactant was found in the dependent lung, regardless of which side the piglet lay on (right side up 15.3 ± 1.0 vs. 3.4 ± 1.0%, p = 0.06, and left side up 11.2 ± 9.8 vs. 1.8 ± 0.7%, p = 0.04). Conclusions: In spontaneously breathing animals on nCPAP, the prone position yielded the highest lung dose. Higher deposition rates in the dependent lung while on lateral decubitus indicates that deposition was also influenced by gravity.
A Porthole over AKI: Cell Dynamics in Damage and Repair
Authors: Bordoni Luca , Sardella Donato , Schiessl Ina Maria
Published: June 2020

Acute kidney injury (AKI) is associated with an increased risk of CKD. Injury-induced multifaceted renal cell-to-cell crosstalk can either lead to successful self-repair or chronic fibrosis and inflammation. In this mini-review, we will discuss critical renal cell types acting as victims or executioners in AKI pathology and introduce intravital imaging as a powerful technique to further dissect these cell-to-cell interactions.
Project Management in Public Health: A Systematic Literature Review on Success Criteria and Factors
Authors: Santos Carolina , Santos Vitor , Tavares António , Varajão João
Published: June 2020

Background: Success is a central concept in project management (PM), yet the literature is relatively extensive and generalist concerning topics related to PM success. Several metrics and factors that influence the success of a project are common to diverse industries, although there are also particularities. In the case of projects and programs developed by public health action, the focus is on protection of the health of specific target groups or populations, and many of them are concerned with survival issues. Summary: As the result of a systematic literature review, this paper identifies general project success criteria and success factors and describes specific evidence for the public health field. Key messages: The success of public health projects needs to be managed systematically and evaluated with a set of comprehensive success criteria.
SOS1
Gain-of-Function Variants in Dilated Cardiomyopathy
Authors: Cowan Jason R. , Salyer Lorien , Wright Nathan T. , Kinnamon Daniel D. , Amaya Pedro , Jordan Elizabeth , Bamshad Michael J. , Nickerson Deborah A. , Hershberger Ray E.
Published: June 2020

Background:

Dilated cardiomyopathy (DCM) is a genetically heterogeneous cardiac disease characterized by progressive ventricular enlargement and reduced systolic function. Here, we report genetic and functional analyses implicating the rat sarcoma signaling protein, SOS1 (Son of sevenless homolog 1), in DCM pathogenesis.

Methods:

Exome sequencing was performed on 412 probands and family members from our DCM cohort, identifying several
SOS1
variants with potential disease involvement. As several lines of evidence have implicated dysregulated rat sarcoma signaling in the pathogenesis of DCM, we assessed functional impact of each variant on the activation of ERK (extracellular signal-regulated kinase), AKT (protein kinase B), and JNK (c-Jun N-terminal kinase) pathways. Relative expression levels were determined by Western blot in HEK293T cells transfected with variant or wild-type human
SOS1
expression constructs.

Results:

A rare
SOS1
variant [c.571G>A, p.(Glu191Lys)] was found to segregate alongside an A-band
TTN
truncating variant in a pedigree with aggressive, early-onset DCM. Reduced disease severity in the absence of the
SOS1
variant suggested its potential involvement as a genetic risk factor for DCM in this family. Exome sequencing identified 5 additional
SOS1
variants with potential disease involvement in 4 other families [c.1820T>C, p.(Ile607Thr); c.2156G>C, p.(Gly719Ala); c.2230A>G, p.(Arg744Gly); c.2728G>C, p.(Asp910His); c.3601C>T, p.(Arg1201Trp)]. Impacted amino acids occupied a number of functional domains relevant to SOS1 activity, including the N-terminal histone fold, as well as the C-terminal REM (rat sarcoma exchange motif), CDC25 (cell division cycle 25), and PR (proline-rich) tail domains. Increased phosphorylated ERK expression relative to wild-type levels was seen for all 6
SOS1
variants, paralleling known disease-relevant
SOS1
signaling profiles.

Conclusions:

These data support gain-of-function variation in
SOS1
as a contributing factor to isolated DCM.