bluuebunny/crossref_metadata_2025 huggingface dataset:
Usefulness of Magnetic Mallet in Oral Surgery and Implantology: A Systematic Review
Authors: Bennardo Francesco , Barone Selene , Vocaturo Camillo , Nucci Ludovica , Antonelli Alessandro , Giudice Amerigo
Published: January 2022

This systematic review aimed to answer the question: “Is the use of magnetic mallet effective in oral and implant surgery procedures in terms of tissue healing, surgery outcome, and complication rate compared to traditional instruments?” A literature search of PubMed, Scopus, and Web of Science databases (articles published until 1 October 2021) was conducted, in accordance with the PRISMA statement, using the keywords “magnetic mallet”, “electric mallet”, “oral surgery”, “implantology”, and “dental implant”. Of 252 articles, 14 were included in the review (3 for teeth extraction, and 11 for implant dentistry). Out of a total of 619 dental extractions (256 patients) performed with the magnetic mallet (MM), no complications were reported. Implants inserted totaled 880 (525 patients): 640 in the MM groups (382), and 240 in control groups (133). The survival rate of implants was 98.9% in the MM groups, and 95.42% in the control groups. Seven patients experienced benign paroxysmal positional vertigo after implant surgery, all in control groups. Results are not sufficient to establish the effectiveness of MM in oral and implant surgery procedures. Randomized controlled trials with a large sample size are needed.
Artificial Intelligence-Based Solution in Personalized Computer-Aided Arthroscopy of Shoulder Prostheses
Authors: Sultan Haseeb , Owais Muhammad , Choi Jiho , Mahmood Tahir , Haider Adnan , Ullah Nadeem , Park Kang Ryoung
Published: January 2022

Background: Early recognition of prostheses before reoperation can reduce perioperative morbidity and mortality. Because of the intricacy of the shoulder biomechanics, accurate classification of implant models before surgery is fundamental for planning the correct medical procedure and setting apparatus for personalized medicine. Expert surgeons usually use X-ray images of prostheses to set the patient-specific apparatus. However, this subjective method is time-consuming and prone to errors. Method: As an alternative, artificial intelligence has played a vital role in orthopedic surgery and clinical decision-making for accurate prosthesis placement. In this study, three different deep learning-based frameworks are proposed to identify different types of shoulder implants in X-ray scans. We mainly propose an efficient ensemble network called the Inception Mobile Fully-Connected Convolutional Network (IMFC-Net), which is comprised of our two designed convolutional neural networks and a classifier. To evaluate the performance of the IMFC-Net and state-of-the-art models, experiments were performed with a public data set of 597 de-identified patients (597 shoulder implants). Moreover, to demonstrate the generalizability of IMFC-Net, experiments were performed with two augmentation techniques and without augmentation, in which our model ranked first, with a considerable difference from the comparison models. A gradient-weighted class activation map technique was also used to find distinct implant characteristics needed for IMFC-Net classification decisions. Results: The results confirmed that the proposed IMFC-Net model yielded an average accuracy of 89.09%, a precision rate of 89.54%, a recall rate of 86.57%, and an F1.score of 87.94%, which were higher than those of the comparison models. Conclusion: The proposed model is efficient and can minimize the revision complexities of implants.
Machine Learning-Based Approaches for Prediction of Patients’ Functional Outcome and Mortality after Spontaneous Intracerebral Hemorrhage
Authors: Guo Rui , Zhang Renjie , Liu Ran , Liu Yi , Li Hao , Ma Lu , He Min , You Chao , Tian Rui
Published: January 2022

Spontaneous intracerebral hemorrhage (SICH) has been common in China with high morbidity and mortality rates. This study aims to develop a machine learning (ML)-based predictive model for the 90-day evaluation after SICH. We retrospectively reviewed 751 patients with SICH diagnosis and analyzed clinical, radiographic, and laboratory data. A modified Rankin scale (mRS) of 0–2 was defined as a favorable functional outcome, while an mRS of 3–6 was defined as an unfavorable functional outcome. We evaluated 90-day functional outcome and mortality to develop six ML-based predictive models and compared their efficacy with a traditional risk stratification scale, the intracerebral hemorrhage (ICH) score. The predictive performance was evaluated by the areas under the receiver operating characteristic curves (AUC). A total of 553 patients (73.6%) reached the functional outcome at the 3rd month, with the 90-day mortality rate of 10.2%. Logistic regression (LR) and logistic regression CV (LRCV) showed the best predictive performance for functional outcome (AUC = 0.890 and 0.887, respectively), and category boosting presented the best predictive performance for the mortality (AUC = 0.841). Therefore, ML might be of potential assistance in the prediction of the prognosis of SICH.
Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent–Umbrella–Bucket Design
Authors: Lamb Joseph J. , Stone Michael , D’Adamo Christopher R. , Volkov Andrey , Metti Dina , Aronica Lucia , Minich Deanna , Leary Michelle , Class Monique , Carullo Malisa , Ryan Jennifer J. , Larson Ilona A. , Lundquist Erik , Contractor Nikhat , Eck Brent , Ordovas Jose M. , Bland Jeffrey S.
Published: January 2022

The working definition of health is often the simple absence of diagnosed disease. This common standard is limiting given that changes in functional health status represent early warning signs of impending health declines. Longitudinal assessment of functional health status may foster prevention of disease occurrence and modify disease progression. The LIFEHOUSE (Lifestyle Intervention and Functional Evaluation-Health Outcomes SurvEy) longitudinal research project explores the impact of personalized lifestyle medicine approaches on functional health determinants. Utilizing an adaptive tent–umbrella–bucket design, the LIFEHOUSE study follows the functional health outcomes of adult participants recruited from a self-insured employee population. Participants were each allocated to the tent of an all-inclusive N-of-one case series. After assessing medical history, nutritional physical exam, baseline functional status (utilizing validated tools to measure metabolic, physical, cognitive, emotional and behavioral functional capacity), serum biomarkers, and genomic and microbiome markers, participants were assigned to applicable umbrellas and buckets. Personalized health programs were developed and implemented using systems biology formalism and functional medicine clinical approaches. The comprehensive database (currently 369 analyzable participants) will yield novel interdisciplinary big-health data and facilitate topological analyses focusing on the interactome among each participant’s genomics, microbiome, diet, lifestyle and environment.
Adipose-Derived Stem Cells for Facial Rejuvenation
Authors: Surowiecka Agnieszka , Strużyna Jerzy
Published: January 2022

The interest in regenerative medicine is increasing, and it is a dynamically developing branch of aesthetic surgery. Biocompatible and autologous-derived products such as platelet-rich plasma or adult mesenchymal stem cells are often used for aesthetic purposes. Their application originates from wound healing and orthopaedics. Adipose-derived stem cells are a powerful agent in skin rejuvenation. They secrete growth factors and anti-inflammatory cytokines, stimulate tissue regeneration by promoting the secretion of extracellular proteins and secrete antioxidants that neutralize free radicals. In an office procedure, without cell incubation and counting, the obtained product is stromal vascular fraction, which consists of not only stem cells but also other numerous active cells such as pericytes, preadipocytes, immune cells, and extra-cellular matrix. Adipose-derived stem cells, when injected into dermis, improved skin density and overall skin appearance, and increased skin hydration and number of capillary vessels. The main limitation of mesenchymal stem cell transfers is the survival of the graft. The final outcomes are dependent on many factors, including the age of the patient, technique of fat tissue harvesting, technique of lipoaspirate preparation, and technique of fat graft injection. It is very difficult to compare available studies because of the differences and multitude of techniques used. Fat harvesting is associated with potentially life-threatening complications, such as massive bleeding, embolism, or clots. However, most of the side effects are mild and transient: primarily hematomas, oedema, and mild pain. Mesenchymal stem cells that do not proliferate when injected into dermis promote neoangiogenesis, that is why respectful caution should be taken in the case of oncologic patients. A longer clinical observation on a higher number of participants should be performed to develop reliable indications and guidelines for transferring ADSCs.
Escalation vs. Early Intense Therapy in Multiple Sclerosis
Authors: Casanova Bonaventura , Quintanilla-Bordás Carlos , Gascón Francisco
Published: January 2022

The treatment strategy of multiple sclerosis (MS) is a highly controversial debate. Currently, there are up to 19 drugs approved. However, there is no clear evidence to guide fundamental decisions such as what treatment should be chosen in first place, when treatment failure or suboptimal response should be considered, or what treatment should be considered in these cases. The “escalation strategy” consists of starting treatment with drugs of low side-effect profile and low efficacy, and “escalating” to drugs of higher efficacy—with more potential side-effects—if necessary. This strategy has prevailed over the years. However, the evidence supporting this strategy is based on short-term studies, in hope that the benefits will stand in the long term. These studies usually do not consider the heterogeneity of the disease and the limited effect that relapses have on the long-term. On the other hand, “early intense therapy” strategy refers to starting treatment with drugs of higher efficacy from the beginning, despite having a less favorable side-effect profile. This approach takes advantage of the so-called “window of opportunity” in hope to maximize the clinical benefits in the long-term. At present, the debate remains open. In this review, we will critically review both strategies. We provide a summary of the current evidence for each strategy without aiming to reach a definite conclusion.
International Dynamic Marketing Capabilities of Emerging-Market Small Business on E-Commerce
Authors: Kim Kihyon , Lim Gyoogun
Published: January 2022

For better export marketing strategies (EMS), companies mobilize their internal resources, which are managerial commitment, firm experience, and product uniqueness. However, Small businesses with constrained resources cannot be well explained with this view. So, more research on how small businesses come up with EMS has been called for. To explain how resource-restricted firms rely heavily on entrepreneurs, this study adopted the concept of dynamic managerial capabilities (DMCs) and resource versatility to better explain small business exports. We analyzed small businesses in Mongolia with qualitative research methods, including interviews with entrepreneurs and support organizations, site visits, and group discussions. We suggest international dynamic marketing capabilities (IDMCs), which are entrepreneurial orientation, networking capability, and versatile dynamic capability for small businesses. Theoretical and managerial implications are discussed.
Overlooked and Under-Studied: A Review of Evidence-Based Enrichment in Varanidae
Authors: Howard Darcy , Freeman Marianne Sarah
Published: January 2022

Enrichment has become a key aspect of captive husbandry practices as a means of improving animal welfare by increasing environmental stimuli. However, the enrichment methods that are most effective varies both between and within species, and thus evaluation underpins successful enrichment programs. Enrichment methods are typically based upon previously reported successes and those primarily with mammals, with one of the main goals of enrichment research being to facilitate predictions about which methods may be most effective for a particular species. Yet, despite growing evidence that enrichment is beneficial for reptiles, there is limited research on enrichment for Varanidae, a group of lizards known as monitor lizards. As a result, it can be difficult for keepers to implement effective enrichment programs as time is a large limiting factor. In order for appropriate and novel enrichment methods to be created, it is necessary to understand a species’ natural ecology, abilities, and how they perceive the world around them. This is more difficult for non-mammalian species as the human-centered lens can be a hinderance, and thus reptile enrichment research is slow and lagging behind that of higher vertebrates. This review discusses the physiological, cognitive, and behavioral abilities of Varanidae to suggest enrichment methods that may be most effective.
Impacts of Urban Expansion on the Loss and Fragmentation of Cropland in the Major Grain Production Areas of China
Authors: Yuan Zifeng , Zhou Liang , Sun Dongqi , Hu Fengning
Published: January 2022

The continuous expansion of urban land has led to massive encroachment upon cropland. To examine the impacts of urban expansion on the loss and fragmentation of cropland in China’s nine major grain production areas (MGPAs), we used standard deviation ellipse, land use transfer matrix, land use dynamic degree, and landscape metric to explore the spatio-temporal evolutions, mutual transfer, and landscape patterns of cropland and urban land. The results show the following: (1) From 1995 to 2018, the areas of cropland in MGPAs showed a trend of “short-term increase—long-term decrease—short-term increase”, while that of urban land grew continuously; (2) Urban expansion is the main cause of cropland loss. The cropland area converted to urban land accounts for a large proportion (49.26%) of the total transfer of cropland to other land types, especially in the densely populated, rapidly urbanizing and industrializing Taihu Lake Plain, Jianghuai Region, and Pearl River Delta; (3) In most MGPAs, urban expansion has led to fragmentation of cropland, especially in the Pearl River Delta, as indicated by the significant change of patch density. However, in the Sanjiang Plain and Songnen Plain, a less pronounced or even reduced cropland fragmentation was observed due to the significant conversion of other land types to cropland under specific land policies. From these results, we suggest that the government should regulate the encroachment of urban land on cropland and the transfer of natural land to it, and encourage the rural land consolidation to increase the cropland.
Characteristics of Soil Erodibility K Value and Its Influencing Factors in the Changyan Watershed, Southwest Hubei, China
Authors: Huang Xiaofang , Lin Lirong , Ding Shuwen , Tian Zhengchao , Zhu Xinyuan , Wu Keren , Zhao Yuanzhe
Published: January 2022

Soil erodibility K factor is an important parameter for evaluating soil erosion vulnerability and is required for soil erosion prediction models. It is also necessary for soil and water conservation management. In this study, we investigated the spatial variability characteristics of soil erodibility K factor in a watershed (Changyan watershed with an area of 8.59 km2) of Enshi, southwest of Hubei, China, and evaluated its influencing factors. The soil K values were determined by the EPIC model using the soil survey data across the watershed. Spatial K value prediction was conducted by regression-kriging using geographic data. We also assessed the effects of soil type, land use, and topography on the K value variations. The results showed that soil erodibility K values varied between 0.039–0.052 t·hm2·h/(hm2·MJ·mm) in the watershed with a block-like structure of spatial distribution. The soil erodibility, soil texture, and organic matter content all showed positive spatial autocorrelation. The spatial variability of the K value was related to soil type, land use, and topography. The calcareous soil had the greatest K value on average, followed by the paddy soil, the yellow-brown soil (an alfisol), the purple soil (an inceptisol), and the fluvo-aquic soil (an entisol). The soil K factor showed a negative correlation with the sand content but was positively related to soil silt and clay contents. Forest soils had a greater ability to resist to erosion compared to the cultivated soils. The soil K values increased with increasing slope and showed a decreasing trend with increasing altitude.
Dynamic Landscape Fragmentation and the Driving Forces on Haitan Island, China
Authors: Ai Jingwen , Yang Liuqing , Liu Yanfen , Yu Kunyong , Liu Jian
Published: January 2022

Island ecosystems have distinct and unique vulnerabilities that place them at risk from threats to their ecology and socioeconomics. Spatially exhibiting the fragmentation process of island landscapes and identifying their driving factors are the fundamental prerequisites for the maintenance of island ecosystems and the rational utilization of islands. Haitan Island was chosen as a case study for understanding landscape fragmentation on urbanizing Islands. Based on remote sensing technology, three Landsat images from 2000 to 2020, landscape pattern index, transect gradient analysis, and moving window method were used in this study. The results showed that from 2000 to 2020, impervious land increased by 462.57%. In 2000, the predominant landscape was cropland (46.34%), which shifted to impervious land (35.20%) and forest (32.90%) in 2020. Combining the moving window method and Semivariogram, 1050 m was considered to be the best scale to reflect the landscape fragmentation of Haitan Island. Under this scale, it was found that the landscape fragmentation of Haitan Island generally increased with time and had obvious spatial heterogeneity. We set up sampling bands along the coastline and found that the degree of landscape fragmentation, advancing from the coast inland, was decreasing. Transects analysis showed the fragmentation intensity of the coastal zone: the north-western and southern wooded zones decreased, while the concentration of urban farmland in the north-central and southern areas increased. The implementation of a comprehensive experimental area plan on Haitan Island has disturbed the landscape considerably. In 2000, landscape fragmentation was mainly influenced by topography and agricultural production. The critical infrastructure construction, reclamation and development of landscape resources have greatly contributed to the urbanisation and tourism of Haitan Island, and landscape fragmentation in 2013 was at its highest. Due to China’s “Grain for Green Project” and the Comprehensive Territorial Spatial Planning policy (especially the protection of ecological control lines), the fragmentation of Haitan Island was slowing. This study investigated the optimal spatial scale for analyzing spatiotemporal changes in landscape fragmentation on Haitan Island from 2000 to 2020, and the essential influencing factors in urban islands from the perspective of natural environment and social development, which could provide a basis for land use management and ecological planning on the island.
Integrating Landscape Pattern into Characterising and Optimising Ecosystem Services for Regional Sustainable Development
Authors: Li Yangbiao , Zeng Chen , Liu Zhixin , Cai Bingqian , Zhang Yang
Published: January 2022

Humans benefit from ecosystem services (ES) and profoundly influence the ecosystem in rapid urbanisation and large-scale urban sprawl contexts, especially at the landscape level. However, the impacts of landscape pattern, the driving mechanism of sub-ES and the spatially explicit regional optimisation, have been largely ignored. In response, to the present paper explores two primary aspects: the relationship among ES, landscape pattern, urban income and agricultural output, and the regional governance of optimised ES values (ESV), using the Wuhan urban agglomeration as a case study area. The survey method is employed in obtaining the adjusted magnitude matrix of land use and ecosystem services. Spatial regression analyses are conducted on each ES, including food provision, climate regulation and soil maintenance, with socio-economic indicators and landscape pattern index as explanatory variables. Finally, geographically weighted regression and scenario analyses are conducted on each sub-ESV to generate adjusted coefficients in each county for ESV regulation. The results show that urban per capita disposable income and agricultural output significantly contribute to ESV change, with the former being negative and the latter being positive. A highly aggregated landscape also produces reduced ESV, particularly in soil maintenance and gas and climate regulation. We summarise the ESV in 2020 and in the period after adjustment in different administrative counties. Provision, regulation and culture ecosystem benefits substantially increase when attempts are made to lower the landscape aggregation pattern by 1%. In general, counties and county-level cities have the largest ESV, with food provision as the optimum ecosystem benefit. Districts in the capital city show an immense growth in provision and regulation, and county-level cities show the highest growth rate in cultural service. Integrating the landscape pattern into characterising and optimising ES, provides references for regional governance on land-use planning and socio-economic development, which is vital to sustainable regional development.
Hydromorphological Inventory and Evaluation of the Upland Stream: Case Study of a Small Ungauged Catchment in Western Carpathians, Poland
Authors: Borek Łukasz , Kowalik Tomasz
Published: January 2022

The hydromorphological conditions of watercourses depend on numerous natural and anthropogenic factors such as buffer zones or human infrastructure near their banks. We hypothesised that, even in a small stream, there can be substantial differences in the hydromorphological forms associated with naturalness and human impact. The paper aims at the field inventory and evaluation of the hydromorphological conditions of a small upland stream in the conditions of contemporary human activity, against the background of meteorological and hydrological conditions. The study concerned a left-bank tributary of the Stradomka River located in the Wiśnicz Foothills (Western Carpathians). The analyses were conducted with the use of the Polish method, the Hydromorphological Index for Rivers (HIR), which conforms to the EU Water Framework Directive (WFD). The hydromorphological condition and quality of habitats were evaluated based on the Hydromorphological Diversity Score (HDS) and Habitat Modification Score (HMS). The study shows that the largest changes in stream hydomorphology and habitat conditions took place in the downstream, urbanised stream catchment area with an intensive development of construction and technical infrastructure. The hydromorphological condition of the examined stream sections was evaluated as good or poor. The best hydromorphological conditions were found in the section located in the semi-natural area, and the worst in the urbanised area. As our research shows, the strong influence of human activity, including weather extremes, and the risks and hydrological hazards of the hydromorphological conditions of the small, ungauged catchment, highlight the necessity to search for other research methods to support the decision-making cycle in the transformation of riverbeds and catchments.
Club Convergence and Spatial Effect on Green Development of the Yangtze River Economic Belt in China with Markov Chains Approach
Authors: Chen Siyu , Peng Chong , Zhang Mengjie , Chen Peng
Published: January 2022

The Yangtze River Economic Belt (YREB) is one of four major national development strategies in China, accomplishing the balance between protection and development of YREB has long-term and comprehensive significance to the implementation of China’s green development concept. This paper aims to have a more comprehensive understanding of the green development level of 126 cities in YREB from 2008 to 2017 by constructing an innovative evaluation system of “capacity level-coordination level-comprehensive level”. And on this basis, further analysis is carried out to check whether there is spatial effect in green development by means of the Markov chain. The main conclusions are as follows: (1) Urban green development comprehensive level in YREB is characterized by convergence, and the convergence phenomenon is more prominent in high-level cities; (2) In general, the distribution of high-value cities is decreasing from east to west; (3) The transition of club convergence is significantly influenced by neighbor background. Overall, the YREB is undergoing a transformation to step into the greener development path, still needs to take a series of synergistic guidance strategies to solve the problem of unbalanced regional development.
New Financial Action Task Force Recommendations to Fight Corruption and Money Laundering
Authors: Yeh Stuart S.
Published: January 2022

A model Anticorruption Protocol to the United Nations Convention against Corruption (APUNCAC) would implement international requirements to report the beneficial ownership of funds involved in certain financial transactions. The purpose is to discourage laundering of illicit funds by attaching legal consequences to each failure to obtain and submit a required report of beneficial ownership, and each failure by a front man who poses as a beneficial owner to supply true information regarding the identity of the actual beneficial owner. This article is the fourth in a series of articles describing APUNCAC’s anti-money laundering (AML) provisions and focus on beneficial owner transparency. The companion articles focused on issues regarding international jurisdiction and enforcement of APUNCAC regarding distant offshore personnel and illustrated the application of APUNCAC to specific money laundering channels. This article translates APUNCAC’s key provisions into proposed Financial Action Task Force (FATF) recommendations, provides guidance regarding the necessary domestic conforming legislation, responds to frequently asked questions, and discusses the rationale for expansion of existing FATF recommendations.
Sleep Apnea Detection Based on Multi-Scale Residual Network
Authors: Fang Hengyang , Lu Changhua , Hong Feng , Jiang Weiwei , Wang Tao
Published: January 2022

Aiming at the fact that traditional convolutional neural networks cannot effectively extract signal features in complex application scenarios, a sleep apnea (SA) detection method based on multi-scale residual networks is proposed. First, we analyze the physiological mechanism of SA, which uses the RR interval signals and R peak signals derived from the ECG signals as input. Then, a multi-scale residual network is used to extract the characteristics of the original signals in order to obtain sensitive characteristics from various angles. Because the residual structure is used in the model, the problem of model degradation can be avoided. Finally, a fully connected layer is introduced for SA detection. In order to overcome the impact of class imbalance, a focal loss function is introduced to replace the traditional cross-entropy loss function, which makes the model pay more attention to learning difficult samples in the training phase. Experimental results from the Apnea-ECG dataset show that the accuracy, sensitivity and specificity of the proposed multi-scale residual network are 86.0%, 84.1% and 87.1%, respectively. These results indicate that the proposed method not only achieves greater recognition accuracy than other methods, but it also effectively resolves the problem of low sensitivity caused by class imbalance.
Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap
Authors: Geistlinger Katharina , Schmidt Jana D. R. , Beitz Eric
Published: January 2022

(1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was assigned to severity. (2) Methods: We expressed AQP9 and human monocarboxylate transporter 1 (MCT1) in yeast to determine the uptake rates and accumulation of radiolabeled l-lactate/l-lactic acid in different external pH conditions. (3) Results: The AQP9-mediated uptake of l-lactic acid was slow compared to MCT1 at neutral and slightly acidic pH, due to low concentrations of the neutral substrate species. At a pH corresponding to the pKa of l-lactic acid, uptake via AQP9 was faster than via MCT1. Substrate accumulation was fundamentally different between AQP9 and MCT1. With MCT1, an equilibrium was reached, at which the intracellular and extracellular l-lactate/H+ concentrations were balanced. Uptake via AQP9 was linear, theoretically yielding orders of magnitude of higher substrate accumulation than MCT1. (4) Conclusions: The selectivity of AQP9 for neutral l-lactic acid establishes an ion trap for l-lactate after dissociation. This may be physiologically relevant if the transmembrane proton gradient is steep, and AQP9 acts as the sole uptake path on at least one side of a polarized cell.
Telemedicine as a Means to an End, Not an End in Itself
Authors: Vitacca Michele , Scalvini Simonetta
Published: January 2022

Telemedicine (TM)—the management of disease at a distance—has potential usefulness for patients with advanced respiratory disease. Underscoring this potential is the dramatic expansion of its applications in clinical medicine. However, since clinical studies testing this intervention often provide heterogeneous results, its role in the medical management of respiratory disorders remains inconclusive. A major problem in establishing TM’s effectiveness is that it is not a single intervention; rather, it includes a number of divergent diagnostic and therapeutic modalities—and each must be tested separately. Reflecting the discord between the need for further documentation of its approaches and effectiveness and its rapid utilization without this needed information, a major challenge is the lack of international guidelines for its integration, regulation, operational plans, and guidance for professionals. Tailored TM, with increased flexibility to address differing healthcare contexts, has the potential to improve access to and quality of services while reducing costs and direct input by health professionals. We should view TM as a tool to aid healthcare professionals in managing their patients with respiratory diseases rather than as a stand-alone substitute to traditional medical care. As such, TM is a means rather than an end.
Multiple Inflammatory Pseudotumors of the Liver Demonstrating Spontaneous Regression: A Case Report
Authors: Ishii-Kitano Noriko , Enomoto Hirayuki , Nishimura Takashi , Aizawa Nobuhiro , Shibata Yoko , Higashiura Akiko , Takashima Tomoyuki , Ikeda Naoto , Yuri Yukihisa , Fujiwara Aoi , Yoshihara Kohei , Yoshioka Ryota , Kawata Shoki , Ota Shogo , Nakano Ryota , Shiomi Hideyuki , Hirota Seiichi , Kumabe Tsutomu , Nakashima Osamu , Iijima Hiroko
Published: January 2022

Inflammatory pseudotumor (IPT) of the liver is a rare benign disease. IPTs generally develop as solitary nodules, and cases with multiple lesions are uncommon. We herein report a case of multiple IPTs of the liver that spontaneously regressed. A 70-year-old woman with a 10-year history of primary biliary cholangitis and rheumatoid arthritis visited our hospital to receive a periodic medical examination. Abdominal ultrasonography revealed multiple hypoechoic lesions, with a maximum size of 33 mm, in the liver. Contrast-enhanced computed tomography revealed low-attenuation areas in the liver with mild peripheral enhancement at the arterial and portal phases. We first suspected metastatic liver tumors, but fluorodeoxyglucose positron emission tomography, magnetic resonance imaging and contrast-enhanced ultrasonography suggested the tumors to be inconsistent with malignant nodules. A percutaneous biopsy showed shedding of liver cells and abundant fibrosis with infiltration of inflammatory cells. Given these findings, we diagnosed the multiple tumors as IPTs. After careful observation for two months, the tumors almost vanished spontaneously. Physicians should avoid a hasty diagnosis of multiple tumors based solely on a few clinical findings, and a careful assessment with various imaging modalities should be conducted.
Pharmacological Effect of GABA Analogues on GABA-ϱ2 Receptors and Their Subtype Selectivity
Authors: Naffaa Moawiah M. , Hibbs David E. , Chebib Mary , Hanrahan Jane R.
Published: January 2022

GABAϱ receptors are distinctive GABAergic receptors from other ionotropic GABAA and metabotropic GABAB receptors in their pharmacological, biochemical, and electrophysiological properties. Although GABA-ϱ1 receptors are the most studied in this subfamily, GABA-ϱ2 receptors are widely distributed in the brain and are considered a potential target for treating neurological disorders such as stroke. The structure of GABA-ϱ2 receptors and their pharmacological features are poorly studied. We generated the first homology model of GABA-ϱ2 channel, which predicts similar major interactions of GABA with the binding-site residues in GABA-ϱ1 and GABA-ϱ2 channels. We also investigated the pharmacological properties of several GABA analogues on the activity of GABA-ϱ2 receptors. In comparison to their pharmacological effect on GABA-ϱ1 receptors, the activation effect of these ligands and their potentiation/inhibition impact on GABA response have interestingly shown inter-selectivity between the two GABA-ϱ receptors. Our results suggest that several GABA analogues can be used as research tools to study the distinctive physiology of GABA-ϱ1 and GABA-ϱ2 receptors. Furthermore, their partial agonist effect may hold promise for the future discovery of selective modulatory agents on GABAA receptors.
Ex Vivo Effect of Novel Lipophosphonoxins on Root Canal Biofilm Produced by Enterococcus faecalis: Pilot Study
Authors: Morozova Yuliya , Voborná Iva , Žižka Radovan , Bogdanová Kateřina , Večeřová Renata , Rejman Dominik , Kolář Milan , Do Pham Duy Dinh , Holík Pavel , Moštěk Roman , Rosa Matej , Pospíšilová Lenka
Published: January 2022

(1) Background: The root canal system has complex anatomical and histological features that make it impossible to completely remove all bacteria by mechanical means only; they must be supplemented with disinfectant irrigation. Current disinfectants are unable to eliminate certain microorganisms that persist in the root canal, resulting in treatment failure. At the Institute of Organic Chemistry and Biochemistry, Prague, novel substances with the bactericidal effect, termed lipophosphonoxins (LPPOs), have been discovered. The aim of this pilot study was to investigate the ex vivo effects of second- and third-generation LPPOs on Enterococcus faecalis and compare them with 5% sodium hypochlorite (NaOCl), 0.12% chlorhexidine digluconate, and 17% ethylenediaminetetraacetic acid (EDTA). (2) Methods: The root canal’s dentin was used as a carrier for biofilm formation in the extracted human mature mandibular premolars. The samples were filled with cultivation broth and 0.25% glucose with tested solutions. In control samples, only fresh cultivation broth (negative control) and cultivation broth with bacterial suspension (growth control) were used. Each sample was inoculated with E. faecalis CCM4224 except for the negative control, and cultivation was performed. To determine the number of planktonic cells, the sample content was inoculated on blood agar. To evaluate biofilm formation inhibition, samples were placed in tubes with BHI. (3) Results: LPPOs exhibited a reduction in biofilm growth and bacteria comparable to NaOCl, and they were superior to other tested disinfectants. (4) Conclusions: The study results suggest the effect of lipophosphonoxins on E. faecalis CCM 4224 reduces planktonic bacterial cells and inhibits formation of biofilm in root canal samples.
Gradual Expansion of a Stent to Prevent Periprocedural Complications after Carotid Artery Stenting for Vulnerable Severe Stenotic Lesions with Intraplaque Hemorrhages: A Retrospective Observational Study
Authors: Mori Takahisa , Yoshioka Kazuhiro , Tanno Yuhei , Kasakura Shigen
Published: January 2022

Vulnerable lesions with intraplaque hemorrhages are associated with a high incidence of complications following carotid artery stenting (CAS). CAS for vulnerable lesions has not been established; therefore, we gradually expand stents in such patients. This study aimed to compare the incidences of complications between gradual-expansion CAS for vulnerable lesions and standard CAS for non-vulnerable lesions. For gradual-expansion CAS, we used 3.0 or 4.0 mm balloons for minimal luminal diameters (MLDs) <2.0 or ≥2.0 mm, respectively, for pre-stenting angioplasty (SA) and did not overinflate them. By contrast, for standard CAS, we used a 4.0 mm balloon and overinflated it to 4.23 mm. A closed-cell stent was deployed, and post-SA was not performed in both groups. We evaluated the MLD before and minimal stent diameter (MSD) immediately after CAS, as well as periprocedural complications of combined stroke, death, and myocardial infarction within 30 days after CAS. In the vulnerable and non-vulnerable groups, 30 and 38 patients were analyzed, the MLDs were 0.76 and 0.96 mm before CAS, the MSDs were 2.97 mm and 3.58 mm after CAS, and the numbers of complications were 0 and 1, respectively. Gradual-expansion CAS for vulnerable lesions was as safe as standard CAS for non-vulnerable lesions.
Epidermal Barrier Function and Skin Homeostasis in Atopic Dermatitis: The Impact of Age
Authors: Montero-Vilchez Trinidad , Cuenca-Barrales Carlos , Rodriguez-Pozo Juan-Angel , Diaz-Calvillo Pablo , Tercedor-Sanchez Jesús , Martinez-Lopez Antonio , Molina-Leyva Alejandro , Arias-Santiago Salvador
Published: January 2022

Skin is damaged in atopic dermatitis (AD) patients. Age is also believed to have a negative effect on epidermal barrier function. The aim of this study was to investigate skin barrier function changes with age in AD patients. A cross-sectional study was conducted including 162 participants, 81 AD patients and 81 healthy volunteers. Skin barrier function parameters, such as transepidermal water loss (TEWL), erythema, temperature, stratum corneum hydration (SCH), pH, and elasticity, were evaluated. Healthy volunteers were evaluated on the volar forearm. AD patients were measured on two regions: on an eczematous lesion on the volar forearm and on a non-involved area 5 cm from the affected area. TEWL was lower on healthy skin than uninvolved AD skin (9.98 vs. 25.51 g·m−2·h−1, p < 0.001) and AD eczematous lesions (9.98 vs. 28.38 g·m−2·h−1, p < 0.001). SCH was lower on AD eczematous lesions than uninvolved AD skin (24.23 vs. 39.36 AU, p < 0.001) and healthy skin (24.23 vs. 44.36 AU, p < 0.001). Elasticity was lower on AD eczematous lesions than uninvolved AD skin (0.69 vs. 0.74, p = 0.038) and healthy skin (0.69 vs. 0.77, p = 0.014). A negative correlation was found between age and elasticity in all the population (r = −0.383, p < 0.001). This correlation was stronger in AD patients (r = −0.494, p < 0.001) than in controls (r = −0.266, p = 0.092). After conducting a linear regression model in AD patients adjusted by age, sex, and SCORing Atopic Dermatitis (SCORAD), it was found that elasticity was impaired by an increasing age (β = −0.004, p < 0.001) and a higher SCORAD (β = −0.003, p < 0.001). The skin barrier function is impaired by age and AD, reflected mainly in poor elasticity values in older AD patients.
Selection of Coal Transportation Company Based on Fuzzy SWARA-COPRAS Approach
Authors: Xiang Ziquan , Naseem Muhammad Hamza , Yang Jiaqi
Published: January 2022

Background: Coal production and marketing enterprises can significantly reduce transportation costs and improve their competitiveness by choosing appropriate road transportation companies. Methods: Based on this, a trapezoidal fuzzy SWARA-COPRAS method is proposed to select coal transportation companies. The trapezoidal fuzzy SWARA method is used to determine the index weight of coal transportation companies. The ranking of coal transportation companies is determined using the trapezoidal fuzzy COPRAS method. Results: Taking a coal production and marketing enterprise in Hubei, China as an example, the application of the trapezoidal fuzzy SWARA-COPRAS method is illustrated, and the coal transportation companies are sorted and analyzed for sensitivity. Conclusions: Compared with the results of other methods, the effectiveness and practicability of the trapezoidal fuzzy SWARA-COPRAS method are verified.
Understanding the Mechanism of Load-Carrying Capacity between Parallel Rough Surfaces through a Deterministic Mixed Lubrication Model
Authors: Wang Yuechang , Azam Abdullah , Zhang Gaolong , Dorgham Abdel , Liu Ying , Wilson Mark C. T. , Neville Anne
Published: January 2022

Experimental results have confirmed that parallel rough surfaces can be separated by a full fluid film. However, such a lift-off effect is not expected by the traditional Reynolds theory. This paper proposes a deterministic mixed lubrication model to understand the mechanism of the lift-off effect. The proposed model considered the interaction between asperities and the micro-elastohydrodynamic lubrication (micro-EHL) at asperities within parallel rough surfaces for the first time. The proposed model is verified by predicting the measured Stribeck curve taken from literature and experiments conducted in this work. The simulation results highlight that the micro-EHL effect at the asperity scale is critical in building load-carrying capacity between parallel rough surfaces. Finally, the drawbacks of the proposed model are addressed and the directions of future research are pointed out.
Study of the Influence of Temperature on Contact Pressures and Resource of Metal-Polymer Plain Bearings with Filled Polyamide PA6 Bushing
Authors: Chernets Myron , Pashechko Mykhaylo , Kornienko Anatolii , Buketov Andriy
Published: January 2022

It is known that the elastic characteristics of polyamides change with increasing temperature; in particular, the Young’s modulus decreases significantly. This fact is practically not taken into account in design calculations of metal-polymer plain (MP) bearings, operating under conditions of the boundary and dry friction. The purpose of the study was the analysis of the effect of temperature on the change of the Young’s modulus and, accordingly, the contact strength and triboresource according to the developed method of calculating MP bearings. MP bearings with a bushing made of polyamide PA6 reinforced with glass or carbon-dispersed fibers were investigated. Quantitative and qualitative regularities of change of the maximum contact pressures and resource of the bearings at temperature increase under conditions of boundary and dry friction are established. The pressures in the bearing bushing made of PA6 + 30GF will be lower than for the bushing made of PA6 + 30CF. The resource of the bushing made of PA6 + 30CF will be significantly greater than for PA6 + 30GF. For thermoplastic polymers, the increase in temperature will have a useful practical effect due to the decrease in the rigidity of the polymer composites of the bearing bushing.
1,3-Dimethyl-3′,5-diphenyl-1,5-dihydro-2H,5′H-spiro[furo[2,3-d]pyrimidine-6,4′-isoxazole]-2,4,5′(3H)-trione
Authors: Ryzhkova Yuliya E. , Kalashnikova Varvara M. , Ryzhkov Fedor V. , Elinson Michail N.
Published: January 2022

Michael addition–halogenation–intramolecular ring-closing (MHIRC) reactions are processes in which a halogen atom as a leaving group can attach to substrates or reactants during the reaction, which then undergoes intramolecular ring closure. In this communication the MHIRC transformation of 4-benzylidene-3-phenylisoxazol-5(4H)-one and 1,3-dimethylbarbituric acid in the presence of N-bromosuccinimide and sodium acetate in EtOH at room temperature was carefully investigated to give novel 1,3-dimethyl-3′,5-diphenyl-1,5-dihydro-2H,5′H-spiro[furo[2,3-d]pyrimi- dine-6,4′-isoxazole]-2,4,5′(3H)-trione in a good yield. The structure of the new compound was confirmed by the results of elemental analysis as well as mass, nuclear magnetic resonance, and infrared spectroscopy.
Effect of Calcination Temperature on Mechanical Properties of Magnesium Oxychloride Cement
Authors: Chang Chenggong , An Lingyun , Lin Rui , Wen Jing , Dong Jinmei , Zheng Weixin , Yan Fengyun , Xiao Xueying
Published: January 2022

In order to make full use of magnesium chloride resources, the development and utilisation of magnesium oxychloride cement have become an ecological and economic goal. Thus far, however, investigations into the effects on these cements of high temperatures are lacking. Herein, magnesium oxychloride cement was calcinated at various temperatures and the effects of calcination temperature on microstructure, phase composition, flexural strength, and compressive strength were studied by scanning electron microscopy, X-ray diffraction, and compression testing. The mechanical properties varied strongly with calcination temperature. Before calcination, magnesium oxychloride cement has a needle-like micromorphology and includes Mg(OH)2 gel and a trace amount of gel water as well as 5 Mg(OH)2·MgCl2·8H2O, which together provide its mechanical properties (flexural strength, 18.4 MPa; compressive strength, and 113.3 MPa). After calcination at 100 °C, the gel water is volatilised and the flexural strength is decreased by 57.07% but there is no significant change in the compressive strength. Calcination at 400 °C results in the magnesium oxychloride cement becoming fibrous and mainly consisting of Mg(OH)2 gel, which helps to maintain its high compressive strength (65.7 MPa). When the calcination temperature is 450 °C, the microstructure becomes powdery, the cement is mainly composed of MgO, and the flexural and compressive strengths are completely lost.
A Novel Graphite-Based Sorbent for Oil Spill Cleanup
Authors: Vocciante Marco , De Folly D’Auris Alessandra , Reverberi Andrea Pietro
Published: January 2022

The performance of an innovative material based on expanded graphite, Grafysorber® G+ (Directa Plus), has been tested through laboratory, tank, and confinement tests for oil removal in case of an oil spill and water treatment. In addition to the ability to retain oil, the possibility of reusing this material after regeneration via squeezing was also evaluated. As a comparison, the same experimental tests were conducted using polypropylene flakes (PP), the material currently most used to deal with spill accidents. Oils with different chemical and physical properties were used, namely kerosene, diesel, and crude oil. From the laboratory tests, the capacity of Grafysorber® G+ to retain oil was found to be directly proportional to the viscosity of the latter, with adsorption values ranging from 76.8 g/g for diesel to 50.8 g/g for kerosene, confirming the potential of the innovative material compared to the PP. Cyclical use tests have confirmed certain reusability of the material, even if its adsorbent capacity decreases significantly after the first cycle and continues to decrease in subsequent cycles, but a less marked manner. Finally, some considerations based on the adsorption capacities were found to suggest that the adoption of the new material is also economically preferable, resulting in savings of 20 to 40% per kg of hydrocarbon treated.