bluuebunny/crossref_metadata_2025 huggingface dataset:
Client Aggression Toward Social Workers and Social Services in Israel—A Qualitative Analysis
Authors: Enosh Guy , Tzafrir Shay S. , Gur Amit
Published: December 2012

The aggressive behavior of clients toward employees in service organizations is an alarming phenomenon, which harms employees and damages the organization itself. Employees all over the public sector, especially in social service departments, are continuously exposed to aggressive behavior by clients. The focus of the current study is on understanding the short- and long-term implications of aggressive client behavior on social workers and the organization in which they operate. A qualitative approach was used to understand the perspective of the workers exposed to aggressive client behavior as well as its organizational implications. In-depth interviews were conducted with the 40 participants between February and May, 2009. The participants included district managers, agency managers, supervisors, social workers, and administrators, in 17 agencies all over the country. The study findings identified negative impacts of client aggression on several levels and on several focal areas. On the emotional, cognitive, and behavioral levels, both short-term and long-term consequences can be seen, which affect not only the attacked individual but also resonate throughout the organization. Individual events may diffuse to affect other levels of the service process by role-learning, imitation of behavior, and by noticing that the organization provides incentives for client aggression, while providing disincentives for assertiveness and self-protective actions on the part of workers.
Race and Ethnicity, Substance Use, and Physical Aggression Among U.S. High School Students
Authors: Mercado-Crespo Melissa C. , Mbah Alfred K.
Published: December 2012

Youth violence is a critical public health problem across races/ethnicities in the United States. Although the differential association between substance use and physical aggression has been empirically proven, no tests have assessed the moderating effects of sociocultural differences in such associations. The purpose of this study is to test the moderating impact of race/ethnicity—as an indicator of sociocultural differences—on the associations between substance use and adolescent aggression, by conducting a validity assessment of a physical aggression measure for high school students with emphasis on Hispanics and other minorities. A cross-sectional, secondary data analysis of the 2007 national Youth Risk Behavior Survey, with a representative sample of all U.S. high school students, was conducted. Contingency table and chi-square test evaluated the statistical relationship between substance use (alcohol, marijuana, either, or both) and self-reports of physical aggression, race/ethnicity, age, and sex of the respondent. Three logistic regression analyses assessed the effect of race/ethnicity on the likelihood of reporting physical aggression by overall substance use and type of substance use. Statistical significant associations were found between physical aggression and alcohol and/or marijuana use. The self-report of substance use (marijuana or alcohol) and alcohol use significantly increased the likelihood of physical aggression across races/ethnicities, highest among racial/ethnic minorities (Blacks > Hispanic > Others > Whites). The differential impact of substance use on physical aggression was confirmed, and such impact was moderated by the sociocultural context (race/ethnicity) of the adolescent. In-depth validity assessments are needed to confirm this study’s predictive validity findings.
Self-Reported Sexual Assault in Convicted Sex Offenders and Community Men
Authors: Widman Laura , Olson Michael A. , Bolen Rebecca M.
Published: December 2012

Although self-reported sexual assault perpetrated by men against women has been well documented among college men, less is known about self-reported perpetration among convicted sex offenders and community men. This study provides unique descriptive and comparative information on sexual assaults in these understudied populations. Participants were 40 convicted sex offenders and 49 demographically comparable community men who completed the Sexual Experiences Survey (SES; Abbey, Parkhill, & Koss, 2005; Koss, Gidycz, & Wisniewski, 1987) and other surveys to capture the promiscuous sex and hostile masculinity pathways posited by the confluence model (Malamuth, 2003). We found notably few differences between sex offenders and community men in the rate and severity of sexual assault perpetration and the tactics used to obtain unwanted sexual contact. Specifically, 68% of sex offenders and 59% of community men acknowledged they had perpetrated sexual assault. Both groups used guilt and anger as the most frequent tactics to obtain unwanted sexual activity from their female victims. Consistent with the confluence model, an impersonal orientation toward sexual relationships was associated with sexual assault for both sex offenders and community men. Future directions for research on sexual assault perpetration and violence prevention efforts are discussed in light of these findings.
Prison Inmates’ Views of Whether Reporting Rape Is the Same as Snitching
Authors: Garland Brett , Wilson Gabrielle
Published: December 2012

Although the prevalence of sexual assault in U.S. prisons is debated, it is known that the consequences for victims can be quite severe. The Prison Rape Elimination Act (PREA) requires prison officials to keep track of incidents of sexual assault, but accurate figures will be generated only to the extent that inmates regularly report these acts. Male rape itself is a highly underreported phenomenon and even less reported in prisons due to inmate cultural norms that frown upon forwarding inmate information to correctional authorities. This article examines whether prison inmates believe that reporting prison rape is equivalent to snitching and analyzes possible explanations for the inmates’ responses. Results indicate that inmates are less likely to view the reporting of prison rape as snitching earlier in their current commitment periods, and White inmates are more likely than Black inmates to think reporting rape is snitching. As this topic is extremely under studied, a number of suggestions for future research are advanced.
Survivor-Defined Practices to Mitigate Revictimization of Battered Women in the Protective Order Process
Authors: Nichols Andrea J.
Published: December 2012

A growing body of research finds that instead of a one-size-fits-all response, community-based responses that include survivor-defined advocacy may prevent further abuse through customized, individualized safety planning and provision of resources. Extant literature related to survivor-defined approaches highlights outcomes, but the work illustrating specifically how these practices work in applied settings is limited. Drawing from interviews with 26 domestic violence victim advocates, the author examines how advocates mitigate revictimization of battered women through survivor-defined practices in the protective order process to provide additional context for this emerging body of work. Findings illustrate that the effectiveness and benefits that an order of protection offered varied from case to case; consequently advocates used survivor-defined approaches to address the specific needs of each woman to better ensure safety.
Feasibility of Screening for Intimate Partner Violence at Orthopedic Trauma Hospitals in India
Authors: Sohani Zahra , Shannon Harry , Busse Jason W. , Tikacz Diana , Sancheti Parag , Shende Mangesh , Bhandari Mohit
Published: December 2012

Background:

Intimate Partner Violence (IPV) involves behavior that causes physical, psychological, or sexual harm, and has significant health consequences. Given the prevalence of and impact of IPV, various organizations recommend routine IPV screening for women by health-care professionals.

Objective:

We investigated the feasibility of screening women for IPV at a hospital in India. Specifically, we assessed prevalence of IPV, method of questionnaire administration, response rate, availability of IPV related community services for referrals, environment of screening, and explored perspectives of health professionals regarding in-hospital screening.

Study Design:

We administered two questionnaires to consenting women; the Composite Abuse Scale (CAS) and Woman Abuse Screening Tool (WAST). Health professionals involved in conducting the study and in managing care for patients were also interviewed.

Results:

Forty-seven patients were enrolled in the study. The most reported injury was fractures (39% [CI 25%-54%]) and the greatest proportion involved spine and neck (28% [CI 16%-43%]). Prevalence of IPV was 30% [CI 17%-45%] according to the WAST and 40% [CI 26%-56%] according to the CAS. A majority of the participants used self-report as the method of questionnaire administration. Additionally, the self-report group had greater disclosure than the interview-administered group. The environment at this private hospital was considered adequate for screening and we found several IPV support networks in the community. However, health professionals were reluctant to screen for IPV.

Conclusions:

Our findings suggest that screening for IPV at an orthopaedic clinic in India is feasible.
The Average Predictive Validity of Intimate Partner Violence Risk Assessment Instruments
Authors: Messing Jill Theresa , Thaller Jonel
Published: December 2012

The field of intimate partner violence (IPV) risk assessment (predicting recidivism, lethality) is fast growing, and the majority of research examining the predictive validity of IPV risk assessment instruments has been conducted in the past decade. This study examines the average predictive validity weighted by sample size of five stand alone IPV risk assessment instruments that have been validated in multiple research studies using the Receiver Operating Characteristic Area Under the Curve (AUC). The Ontario Domestic Assault Risk Assessment (ODARA) has the highest average weighted AUC (=.666, k=5) followed, in order of most to least predictive, by the Spousal Assault Risk Assessment (SARA; AUC=.628, k=6), the Danger Assessment (DA; AUC=.618, k=4), the Domestic Violence Screening Inventory (DVSI; AUC=.582, k=3), and the Kingston Screening Instrument for Domestic Violence (K-SID; AUC=.537, k=2). The effect size for the average AUCs for IPV risk assessment instruments is small, with the exception of a medium effect size for the ODARA. Of the 20 measures of predictive validity included in this analysis, the risk assessment was administered correctly in nine (45%). IPV risk assessment is relatively new, and the use of proxy instruments and utilization of risk assessment instruments in settings for which they were not created is widespread. While waiting for a more rigorous body of research, factors in addition to predictive validity must be taken into consideration (e.g., setting, outcome, skills of the assessor, access to information) when choosing which risk assessment instrument is appropriate for use in a particular practice setting.
Gender and Age Differences in Self-Reported Aggression of High School Students
Authors: Tsorbatzoudis Haralambos , Travlos Antonios K. , Rodafinos Angelos
Published: December 2012

The purpose of the study was to (a) investigate gender and age differences in physical aggression, verbal aggression, anger, and hostility, and (b) examine the discriminatory power of the Greek version of the Aggression Questionnaire (GAQ) with high school students. The sample of the study consisted of 658 high school students (321 boys and 337 girls), with an age range from 13 to 17 years ( M = 15.3, SD = 1.5). The students completed the Aggression Questionnaire adapted to Greek. Regarding gender, the overall correct identification rate in the discriminant analysis showed that 73.3% of the cases were correctly classified. In addition, the results indicated that physical aggression declined with age and that, compared to boys, girls of higher grades apply more indirect forms of aggression, such as anger and hostility. The findings of the study provide important information regarding the expression of aggressive behavior during adolescence.
Confronting the Gender Myth
Authors: Morrill Mandy , Bachman Curt
Published: December 2012

Research on family violence has overwhelmingly focused on a patriarchal model, which inaccurately depicts men as exclusively perpetrators and women as exclusively victims of abusive family acts. In addition, empirical research on sibling abuse in families has been significantly absent from the professional literature. This exploratory study used a survey instrument based on an altered version of the Conflict Tactics Scale (CTS) to investigate the question of whether significant gender differences exist in the experience of sibling abuse as a child, either as perpetrator or victim. MANOVAs (multivariate analyses of variance) indicate that there are no gender differences related to surviving sibling abuse or perpetrating emotional and physical abuse, whereas it was found that women had a significantly higher rate of perpetration related to sibling sexual abuse. Specific results related to the gender variance of perpetrators are explored. Limitations as well as implications of these findings on treatment, counselor education, and future research are discussed.
Differences in Social Network Structure and Support Among Women in Violent Relationships
Authors: Katerndahl David , Burge Sandra , Ferrer Robert , Becho Johanna , Wood Robert
Published: December 2012

Social support is critical for women in abusive relationships. While social support may decrease the risk of getting into a violent relationship, it can also allow battered women to remain in violent relationships by reducing the negative impact of intimate partner violence (IPV). In addition to the social isolation that women in abusive relationships may experience, her social contacts appear to be important. The purpose of this study was to compare the size, structure, and composition of the social networks of women in abusive relationships with those of a matched cohort of nonabused women. The authors enrolled women from primary care clinics who reported abuse within the prior month, and a demographically matched comparison group of women in nonabusive relationships. Participants completed a social network analysis, and investigators compared social networks of abused with nonabused women. The networks of women in abusive relationships were smaller in size, but more efficient in their ability to reach their members, than those of nonabused women. Proportionally, networks of abused women had more women but fewer in-laws than those of comparison women. The women in these abusive relationships had higher measures of centrality, suggesting that they were more critical in holding their networks together. Yet, they had fewer social contacts, and provided more support than they received with fewer reciprocated ties. Thus, social networks of women in violent relationships are small and offer less support than those of comparison women. However, previous work on networks with weak ties and structural holes suggests that access to resources may be available through these networks.
An Ecological Examination of Factors Influencing Men’s Engagement in Intimate Partner Violence Groups
Authors: Roy Valérie , Châteauvert Joanie , Richard Marie-Claude
Published: December 2012

This article examines the findings of an ecological analysis of the factors influencing men’s engagement in intimate partner violence (IPV) groups. Individual interviews and two focus groups were conducted with men who participated in group programs in two agencies in Canada. Our qualitative analysis of interviews and focus groups suggested that both individual and program-related factors were determinants in the men’s engagement. These findings drew our attention to the influence of certain factors outside of the group therapy, in particular organizational practices. Implications for practice are explored, in particular the role of time in the intervention, and implications for research and limitations are discussed.
Gauging the Emerging Plus-Size Footwear Market An Anthropometric Approach
Authors: Park Juyeon
Published: December 2012

In order to gauge the emerging needs for the plus-size footwear market, this study tested the following four hypotheses: 1) as BMI increases, foot morphology changes; 2) increased BMI influences consumers' footwear selection criteria; 3) increased BMI negatively affects consumers' footwear fit; and 4) increased BMI negatively affects consumers' satisfaction with the current footwear market. One hundred and twenty-one female college students were recruited from a large 4-year U.S. university, and only Caucasian data (n=99) were used for statistical analysis. Prior to 3D scanning, a short questionnaire was administered to assess the participants' footwear selection criteria and satisfaction with the current footwear offerings, as well as demographic information. Anthropometry of the participants' feet was measured, using a 3D foot scanner (INFOOT® by I-ware). Results showed that BMI positively affected the increase of anthropometric measurements; as BMI increased, the participants indicated significantly higher scores on shoe length and insole cushion and a lower score on fashion trendiness in the perceived importance of footwear selection criteria; they tended to wear improperly fitting shoes to accommodate wider and thicker feet; and they were significantly less satisfied with the current market than those with a lower BMI. Strong relationships in all four hypotheses were evident, and findings of this study urged the footwear manufacturing industry to recognize the unfulfilled niche market for the growing population of plus-size consumers.
No Child Left Bilingual
Authors: Menken Kate , Solorza Cristian
Published: December 2012

Although educational policies for emergent bilinguals in New York City schools have historically supported the provision of bilingual education, the past decade has borne witness to a dramatic loss of bilingual education programs in city schools. This study examines the factors that determine language education policies adopted by school principals, through qualitative research in 10 city schools that have eliminated their bilingual education programs in recent years and replaced them with English-only programs. Our findings draw a causal link between the pressures of test-based accountability imposed by No Child Left Behind and the adoption of English-only policies in city schools. Testing and accountability are used as the justification for dismantling bilingual education programs and create a disincentive to serve emergent bilingual students, as schools are far more likely to be labeled low performing and risk sanctions such as closure simply for admitting and educating these students.
Health Status and Behavioral Risk Factors in Older Adult Mexicans and Mexican Immigrants to the United States
Authors: Aguila Emma , Escarce Jose , Leng Mei , Morales Leo
Published: December 2012

Objectives: Investigate the “salmon-bias” hypothesis, which posits that Mexicans in the U.S. return to Mexico due to poor health, as an explanation for the Hispanic health paradox in which Hispanics in the United States are healthier than might be expected from their socioeconomic status. Method: Sample includes Mexicans age 50 years or above living in the United States and Mexico from the 2003 Mexican Health and Aging Study and the 2004 Health and Retirement Study. Logistic regressions examine whether nonmigrants or return migrants have different odds than immigrants of reporting a health outcome. Results: The salmon-bias hypothesis holds for select health outcomes. However, nonmigrants and return migrants have better health outcomes than immigrants on a variety of indicators. Discussion: Overall, the results of this study do not support the salmon-bias hypothesis; other explanations for the paradox could be explored.
Neighborhood Resources and Social Participation Among Older Adults
Authors: Richard Lucie , Gauvin Lise , Kestens Yan , Shatenstein Bryna , Payette Hélène , Daniel Mark , Moore Spencer , Levasseur Mélanie , Mercille Geneviève
Published: December 2012

Objective: This article examined the associations between proximity to selected locations considered to be conducive to social participation, and social participation itself, in urban-dwelling seniors. Methods: A sample of 520 older adults residing in the Montreal area provided reports of social participation and information about health, sociodemographic characteristics, social networks, and perceptions about features of their residential environment. Information about the distance between their home and five locations deemed to be conducive to social participation were obtained from a geographic information system. Results: Analyses showed a significant association between proximity to selected locations and social participation while accounting for individual characteristics and perceptions of neighborhood features (β = 0.37; SE = 0.17; p < 0.05). Discussion: Findings were consistent with contributions highlighting the impact of the built environment on seniors’ health-related behavior. Future work would benefit from the use of longitudinal designs and examinations of social participation through alternate channels.
Latent Heterogeneity in Long-Term Trajectories of Body Mass Index in Older Adults
Authors: Botoseneanu Anda , Liang Jersey
Published: December 2012

Objectives: To evaluate latent heterogeneity in long-term trajectories of body weight in older adults. Methods: We analyzed 14-year longitudinal data on 10,314 older adults from the Health and Retirement Study. Semiparametric mixture models identified latent subgroups of similar trajectories of body mass index (BMI). Results: Five distinct trajectory subgroups emerged: normal starting-BMI with accelerated increase over time (trajectory #1), overweight and increasing (trajectory #2), borderline-obese and increasing (trajectory #3), obese and increasing (trajectory #4), and morbidly obese with decelerating gain (trajectory #5). Blacks and Hispanics had greater risk of membership in ascending high-BMI trajectory groups. Females had approximately half the risk of following overweight and obese increasing BMI trajectories compared with males. Discussion: Distinct latent subgroups of BMI trajectories and significant racial/ethnic and gender trajectory heterogeneity exist in the older adult population. The propensity of men and minorities to experience high-risk BMI trajectories may exacerbate existing disparities in morbidity/ mortality in older age.
Volume rendering of three-dimensional fluoroscopic images for percutaneous scaphoid fixation: An in vitro study
Authors: Smith Erin J , Al-Sanawi Hisham , Gammon Braden , Pichora David R , Ellis Randy E
Published: December 2012

Percutaneous fixation of scaphoid fractures offers potential advantages to cast treatment but can be difficult to perform with conventional two-dimensional imaging. This study aimed to evaluate the use of a novel navigation technique using volume-rendered images derived from intraoperative cone-beam computed tomography imaging, without the need for typical patient-based registration. Randomized in vitro trials in which a guidewire was inserted into a scaphoid model were conducted to compare volumetric navigation to conventional fluoroscopic C-arm (n = 24). Central wire placement, surface breach, procedure time, drilling attempts, and radiation exposure were compared between groups. Compared to conventional percutaneous insertion, navigation achieved equal or significantly better placement of the guidewire with fewer drilling attempts and less radiation exposure. On average, navigation took 74 s longer to perform than the conventional method, which was statistically significant but clinically irrelevant. This evaluation suggests that the technology is promising and may have many clinical benefits including improved fixation placement, fewer complications, and less radiation exposure. The intraoperative workflow is more efficient and eliminates the need for preoperative computed tomography, image segmentation, and patient-based registration typical of traditional navigated procedures.
Experiencing Discrimination Increases Risk Taking
Authors: Jamieson Jeremy P. , Koslov Katrina , Nock Matthew K. , Mendes Wendy Berry
Published: December 2012

Prior research has revealed racial disparities in health outcomes and health-compromising behaviors, such as smoking and drug abuse. It has been suggested that discrimination contributes to such disparities, but the mechanisms through which this might occur are not well understood. In the research reported here, we examined whether the experience of discrimination affects acute physiological stress responses and increases risk-taking behavior. Black and White participants each received rejecting feedback from partners who were either of their own race (in-group rejection) or of a different race (out-group rejection, which could be interpreted as discrimination). Physiological (cardiovascular and neuroendocrine) changes, cognition (memory and attentional bias), affect, and risk-taking behavior were assessed. Significant Participant Race × Partner Race interactions were observed. Cross-race rejection, compared with same-race rejection, was associated with lower levels of cortisol, increased cardiac output, decreased vascular resistance, greater anger, increased attentional bias, and more risk-taking behavior. These data suggest that perceived discrimination is associated with distinct profiles of physiological reactivity, affect, cognitive processing, and risk taking, implicating direct and indirect pathways to health disparities.
Adding Small Differences Can Increase Similarity and Choice
Authors: Kim Jongmin , Novemsky Nathan , Dhar Ravi
Published: December 2012

Similarity plays a critical role in many judgments and choices. Traditional models of similarity posit that increasing the number of differences between objects cannot increase judged similarity between them. In contrast to these previous models, the present research shows that introducing a small difference in an attribute that previously was identical across objects can increase perceived similarity between those objects. We propose an explanation based on the idea that small differences draw more attention than identical attributes do and that people’s perceptions of similarity involve averaging attributes that are salient. We provide evidence that introducing small differences between objects increases perceived similarity. We also show that an increase in similarity decreases the difficulty of choice and the likelihood that a choice will be deferred.
Inhabiting the contradictions: Hypersexual femininity and the culture of intoxication among young women in the UK
Authors: Griffin Christine , Szmigin Isabelle , Bengry-Howell Andrew , Hackley Chris , Mistral Willm
Published: December 2012

This paper contributes to debates on post-feminism and the constitution of contemporary femininity via an exploration of young women’s alcohol consumption and their involvement in normative drinking cultures. We view femininity as a profoundly contradictory and dilemmatic space which appears almost impossible for girls or young women to inhabit. The juxtaposition of hyper-sexual femininity and the culture of intoxication produces a particularly difficult set of dilemmas for young women. They are exhorted to be sassy and independent – but not feminist; to be ‘up for it’ and to drink and get drunk alongside young men – but not to ‘drink like men’. They are also called on to look and act as agentically sexy within a pornified night-time economy, but to distance themselves from the troubling figure of the ‘drunken slut’. Referring to recent research on young women’s alcohol consumption and our own study on young adults’ involvement in the culture of intoxication in the UK, we consider the ways in which young women manage to inhabit this terrain, and the implications for contemporary feminism and safer drinking initiatives .
Ethanol elimination kinetics following massive ingestion in an ethanol naive child
Authors: Wiener Sage W , Olmedo R , Howland MA , Nelson LS , Hoffman RS
Published: December 2012

Objective:

At low-to-moderate concentrations, ethanol elimination follows zero-order kinetics. It is unknown whether renal, pulmonary or other first-order processes become significant in patients with very high serum ethanol concentrations. Additionally, it is unclear whether ethanol naive subjects induce their metabolism during acute intoxication. We present the toxicokinetic analysis in a child with a massive ingestion of ethanol.

Case report:

A 15-year-old girl without significant medical history presented to the Emergency Department after drinking 24 ounces of tequila. She was found unresponsive at home with a Glasgow Coma Score of 3. Her presenting vitals were as follows: 118/69 mmHg blood pressure; pulse rate was 88 beats per minute; respiratory rate of 20 breaths per minute; pulse-oximetry is 96% on room air. Other than obtundation, her physical examination was normal. She was intubated for airway protection and admitted to the ICU. Her initial serum ethanol concentration was 543 mg/dL. A repeat level 3 h later was 722 mg/dL. Post-absorptive ethanol concentrations decreased from 693 mg/dL to 291 mg/dL over the following 15.5 h. The patient had spontaneous eye opening 24 h after presentation. Her projected serum ethanol concentration at that time was 215 mg/dL. She was extubated 2 h later and had an uneventful recovery.

Results:

The elimination of ethanol in the post-absorptive phase remained zero-order at a rate of 26.3 mg/dL/h (5.7 mmol/L/h) with a Pearson’s correlation coefficient ( R2) of 0.9968 ( p < 0.01). There was no evidence of acute induction in metabolism although pharmacodynamic tolerance likely occurred.

Conclusion:

Even at very high ethanol concentrations in ethanol naive subjects, elimination of ethanol follows a zero-order toxicokinetic model.
Viscum album agglutinin-I (VAA-I) increases cell surface expression of cytoskeletal proteins in apoptotic human neutrophils
Authors: Simon M.M. , Simard J.C. , Girard D.
Published: December 2012

Viscum album agglutinin-I (VAA-I) is a plant lectin, which possesses anti-inflammatory properties, including the ability to induce neutrophil apoptosis by a mechanism that is not completely understood. Among the three actin-binding membrane-anchoring proteins ezrin/radixin/moesin (ERM), neutrophils are known to express ezrin and moesin. The behavior of these proteins in apoptotic neutrophils is not well established. In the present study, the expression and localization of ezrin and moesin by Western blot and immunofluorescence revealed a clear degradation and relocalization of both the proteins during VAA-I-induced apoptosis. Also, flow cytometry analysis revealed that VAA-I markedly and significantly induced the cell surface expression of ezrin and moesin and this was reversed when cells were pretreated with the Syk inhibitor piceatannol. The expression of ezrin and moesin on the cell surface of apoptotic neutrophils may represent a mechanism responsible for the appearance of autoantibodies directed against ERM proteins, which have been found in the serum of patients suffering from autoimmune diseases. Therefore, the ability of VAA-I to increase cell surface expression of cytoskeletal proteins in apoptotic neutrophils provides important insight into a possible toxic mechanism of this plant lectin and this has to be considered for its potential utilization for in vivo treatment.
Consequences of manganese administration for striatal dopamine and motor behavior in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed C57BL/6 mice
Authors: Dodd C.A. , Bloomquist J.R. , Klein B.G.
Published: December 2012

Environmental compounds may be important contributors to Parkinson’s disease etiology. Epidemiological and experimental evidence for the facilitation of parkinsonism by manganese is equivocal. This work addressed methodological concerns in the few studies of manganese modulation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced toxicity in C57BL/6 mice. Male, retired breeder mice received 0 or 100 mg/kg of manganese chloride (MnCl2; subcutaneously on days 1, 4 and 7) and 0 or 20 mg/kg of MPTP (intraperitoneally on day 8) and survived up to day 15 or 22. On the day of sacrificing, horizontal (grid crossing) and vertical (rearing) open field movement, swimming, grip strength and grip fatigue were examined. Striata were analyzed for dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) using high-performance liquid chromatography. MPTP produced a main effect decrease in striatal dopamine (48.8%) and DOPAC (38.1%), but there was no main effect of MnCl2 or MnCl2 × MPTP interaction. However, modulatory interactions were observed between the effects of MnCl2 and MPTP for grid crossing, rearing and grip strength. Interestingly, these interactions reduced the severity of behavioral deficits attributable to either of these compounds alone. For rearing and grip strength, the MnCl2 × MPTP interaction was dependent upon survival time. The mechanistic nature of the MnCl2 × MPTP interaction upon these behaviors, in the absence of such an interaction for striatal dopamine and DOPAC, remains to be clarified.
Assessment of cytotoxic and apoptotic effects of benzaldehyde using different assays
Authors: Ulker Z. , Alpsoy L. , Mihmanli A.
Published: December 2012

Benzaldehyde (BA) occurs naturally in a number of plants, including cherry, fig and peach fruit and carnation flowers at therapeutic doses. In addition, it is used in cosmetics, personal care products and food as a preservative. In this study, we aimed to determine the cytotoxic and apoptotic effects of different concentrations of BA on cultured human lymphocytes using lactate dehydrogenase assay, cell proliferation (water-soluble tetrazolium salts-1) assay and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) test (apoptotic test) as a group of cytotoxicity tests at 6th and 24th h on human lymphocyte cell culture. The cytotoxicity increased when cells were treated with 10, 25 and 50 μg/mL concentrations of BA ( p < 0.05). Moreover, treatment of the cells with the same concentrations significantly decreased the cell number at the 6th and 24th hours ( p < 0.05). TUNEL assay results also show that the concentration of BA at 10, 25 and 50 μg/mL caused DNA damage significantly ( p < 0.05). According to our results, the toxic and genotoxic effects of BA have to be further evaluated before using in cosmetic and food products.
Manganese activates caspase-9-dependent apoptosis in human bronchial epithelial cells
Authors: Zhang L , Sang H , Liu Y , Li J
Published: December 2012

Acute inhalation exposure to high levels of manganese (Mn) is associated with pulmonary edema and impaired function. The immune-mediated lung epithelium injury of Mn in vivo and in vitro experiments has been well characterized, whereas its apoptotic effect is not well defined. Our results show that human bronchial epithelial (16HBE) cells undergo caspase-9-mediated cell death in response to Mn. Loss of mitochondrial membrane potential (ΔΨm), the formation of reactive oxygen species and release of cytochrome c were regulated during this process. In addition, decreasing c-Myc level and increasing of phosphorylated p53 (Ser 15) and WAF1/p21 were also taken part in Mn-mediated lung toxicity. Proteasome inhibitor MG132 could increase c-Myc protein in abundance. Taking together, our results demonstrate that caspase-9-dependent intrinsic pathway, the downregulation of c-Myc and the upregulation of p53 and phosphorylated p53 might be responsible for Mn-mediated apoptosis in 16HBE cells. Moreover, c-Myc decrease might be due to increased degradation through the ubiquitin–proteasome pathway.
A cure rate survival model under a hybrid latent activation scheme
Authors: Borges Patrick , Rodrigues Josemar , Louzada Francisco , Balakrishnan Narayanaswamy
Published: December 2012

In lifetimes studies, the occurrence of an event (such as tumor detection or death) might be caused by one of many competing causes. Moreover, both the number of causes and the time-to-event associated with each cause are not usually observable. The number of causes can be zero, corresponding to a cure fraction. In this article, we propose a method of estimating the numerical characteristics of unobservable stages (such as initiation, promotion and progression) of carcinogenesis from data on tumor size at detection in the presence of latent competing causes. To this end, a general survival model for spontaneous carcinogenesis under a hybrid latent activation scheme has been developed to allow for a simple pattern of the dynamics of tumor growth. It is assumed that a tumor becomes detectable when its size attains some threshold level (proliferation of tumorais cells (or descendants) generated by the malignant cell), which is treated as a random variable. We assume the number of initiated cells and the number of malignant cells (competing causes) both to follow weighted Poisson distributions. The advantage of this model is that it incorporates into the analysis characteristics of the stage of tumor progression as well as the proportion of initiated cells that had been ‘promoted’ to the malignant ones and the proportion of malignant cells that die before tumor induction. The lifetimes corresponding to each competing cause are assumed to follow a Weibull distribution. Parameter estimation of the proposed model is discussed through the maximum likelihood estimation method. A simulation study has been carried out in order to examine the coverage probabilities of the confidence intervals. Finally, we illustrate the usefulness of the proposed model by applying it to a real data involving malignant melanoma.
The Laws of Memory
Authors: Campbell Kirsten
Published: December 2012

The International Criminal Tribunal for the former Yugoslavia (ICTY) has generated huge archival holdings. With the ICTY’s impending closure, the archive has become part of broader debates regarding its legacy for the former Yugoslavia. In particular, the memorial function of this archive has now become highly contentious. Ultimately, these concern the relationship between law and collective memory. This article uses the example of the ICTY archive to explore the relationship between law and memory in post-conflict transition. It argues that this ‘legal archive’ functions as a mnemonic system that produces ‘legal memory’ through its juridical, international, and transitional structure. It then considers the competing discourses of how the legal archive remembers or forgets the justice of law and the injustice of war. Ultimately, these discourses figure the archive as a ‘legal memorial’ that fails to produce collective memory. For this reason, I develop an alternative concept of ‘memorial law’ in order to suggest other memorial practices that can sustain legal memory as a living memory, rather than as a dead archive.
Surviving the Aftershock
Authors: Ghose Toorjo , Boucicaut Edner , King Charles , Doyle Andrea , Shubert Virginia
Published: December 2012

In this research we examined how the conditions of Haiti’s tent communities, inhabited by those displaced by the January 10, 2010, earthquake, shaped access and adherence to highly active antiretroviral treatment (HAART) for Haitians with HIV. Conditions in the encampments were marked by unhygienic and cramped living spaces, exposure to the elements, a lack of privacy, unavailability of food and clean water, and a dependence on poorly functioning aid agencies. These conditions shaped access and adherence to HAART by (a) exacerbating the stigma of being HIV positive and undermining mental health; (b) presenting logistical challenges to accessing medical care, storing pills, and ingesting them safely and privately; and (c) sustaining a political economy of aid characterized by unequal treatment in major HAART-dispensing centers, unequal circulation of international funds, and the emergence of alternative medical institutions within encampments that could improve future treatment. Policy and intervention implications are discussed.
Beyond Barriers in Studying Disparities in Women’s Access to Health Services in Ontario, Canada
Authors: Angus Jan E. , Lombardo Anthony P. , Lowndes Ruth H. , Cechetto Naomi , Ahmad Farah , Bierman Arlene S.
Published: December 2012

Women live within complex and differing social, economic, and environmental circumstances that influence options to seek health care. In this article we report on a metasynthesis of qualitative research concerning access disparities for women in the Canadian province of Ontario, where there is a publicly funded health care system. We took a metastudy approach to analysis of results from 35 relevant qualitative articles to understand the conditions and conceptualizations of women’s inequitable access to health care. The articles’ authors attributed access disparities to myriad barriers. We focused our analysis on these barriers to understand the contributing social and political forces. We found that four major, sometimes countervailing, forces shaped access to health care: (a) contextual conditions, (b) constraints, (c) barriers, and (d) deterrents. Complex convergences of these forces acted to push, pull, obstruct, and/or repel women as they sought health care, resulting in different patterns of inequitable access.
Reconstruction of Health-Seeking Behaviors
Authors: Choi Jin Young
Published: December 2012

In this article, I explore how health-seeking behaviors of immigrants are reconstructed and shaped during the adaptation process by comparing the experiences of three Asian Pacific immigrant groups in Hawaii: Filipinos, Koreans, and Marshallese. A total of 91 participants (52 new immigrants, 22 ethnic community key informants, and 17 service providers) completed in-depth interviews. All three groups of immigrants experienced significant changes in their health-seeking behaviors, but in different ways. Koreans experienced a dramatic decrease in seeking both primary and preventive health care after immigration, whereas Filipinos and Marshallese increased their health-seeking behaviors. Coupled with the previous health care experiences in their home country and individual characteristics, the social context of the host country, to a great degree, influenced the formation of health-seeking behaviors after immigration. The study findings suggest that tailored interventions should take into account the source of behavioral change and difficulties that each immigrant group experiences.
Jewish Israeli Social Workers’ Responses to Ethnic Health Inequality
Authors: Baum Nehami
Published: December 2012

In this study I explored the perceptions and responses of Jewish Israeli social workers to the health inequalities facing their Arab clients. Findings drawn from face-to-face, in-depth interviews with 26 Jewish Israeli social workers employed in the health field show that they were highly aware of the health inequalities. Although they uniformly insisted that there was no discrimination in the hospitals where they were employed, they observed extensive structural and individual discrimination outside the hospital and linguistic and sociocultural impediments to health equality within it. The discrimination provoked feelings of anger and moral outrage, guilt, and shame. Both the discrimination and the linguistic and sociocultural impediments filled them with frustration and led them, both individually and in concert with colleagues, to try to alleviate, circumvent, correct, or compensate for the impediments. Suggestions are made for practice and further research.
Adolescent Fathers in the Justice System
Authors: Shade Kate , Kools Susan , Pinderhughes Howard , Weiss Sandra J.
Published: December 2012

Using a constructivist grounded theory approach, we explored the development of father identity among boys involved in the juvenile justice system. Youth were recruited from a juvenile detention center and school district in a northern California county with a high teen birth rate. The participants were expecting a child or parenting an infant and had been arrested, incarcerated, or had committed a crime. We collected data through observations and individual interviews. Using constant comparative and dimensional analysis, we found that expectant adolescent fathers hoped for a boy and envisioned their central role as father to be making their son a man. This article contributes to greater understanding of father identity development for youth involved in the justice system. We suggest that teen parenting policies and programs include interventions sensitized by gender, accounting for the influence masculine ideals of manhood have on the development of father identity and the father–child relationship.
Cancer Patients’ Experiences of the Early Phase of Individual Counseling in an Outpatient Psycho-Oncology Setting
Authors: Nekolaichuk Cheryl L. , Turner Jill , Collie Kate , Cumming Ceinwen , Stevenson Audrey
Published: December 2012

Distress is a common and substantive problem associated with the invasive nature of cancer. Psychosocial interventions can alleviate distress and enhance quality of life, with a wealth of research demonstrating benefits of group interventions. Less is known, however, about the value of individual psychological counseling for cancer patients. The goal of our study was to understand patients’ experiences of attending an individual psycho-oncology counseling service in a comprehensive cancer center in Canada. We conducted six focus groups to ask patients about their perceived benefits of the early phase of counseling. The 23 participants were predominantly women living in urban areas who sought counseling for emotional and coping difficulties. Using inductive analysis, we identified four interrelated themes: distress and need for support, challenges to service access, service benefits, and the therapeutic encounter. The therapeutic encounter formed a core component of patients’ experiences, highlighting the benefits of specific therapeutic interventions and processes.
Health and Wellness Photovoice Project
Authors: Cabassa Leopoldo J. , Parcesepe Angela , Nicasio Andel , Baxter Ellen , Tsemberis Sam , Lewis-Fernández Roberto
Published: December 2012

People with serious mental illnesses (SMI) are at increased risk for cardiovascular disease and premature mortality. We used photovoice in two supportive housing agencies to engage consumers with SMI to inform the implementation of health care interventions. Sixteen consumers participated in six weekly sessions in which they took photographs about their health and discussed the meanings of these photographs in individual interviews and group sessions. We identified several implementation themes related to consumers’ preferences. Peer-based approaches were preferred more than clinician-driven models. Participants expressed a desire to learn practical skills through hands-on activities to modify health behaviors. Consumers expressed a desire to increase their physical activity. Participants revealed in their photographs and narratives the important role that communities’ food environments play in shaping eating habits. In this article, we show how photovoice can generate valuable community knowledge to inform the translation of health care interventions in supportive housing agencies.