bluuebunny/crossref_metadata_2025 huggingface dataset:
Ta inte de grundläggande begreppen inom naturvetenskapen för givna
Authors: Nilsson Gunilla Åkesson
Published: May 2022

Förståelsen för att materia och organismer består av mindre partiklar samt massans bevarande är grunden för att lära sig naturvetenskap. Vidare är det inom naturvetenskapen betydelsefullt att förstå hur de olika fysikaliska egenskaperna kan uppkomma och förändras i en produkt. Det är därför viktigt att känna till skillnaden mellan begreppen rena ämne och blandningar, eftersom rena substanser har ofta precisa och beständiga fysikaliska egenskaper, vilket en blandning inte har. Men att lära sig dessa begrepp har visat sig vara besvärligt.

Syftet med denna studie var att låta studenter som läser kemi 1 på tekniskt basår genomföra olika praktiska övningar om materiens partikelnatur för att se om denna undervisningsform skulle kunna öka deras förståelse för massans bevarande. Vidare utvecklades en modell ”Produktens rotsystem av ämnen” för att träna på att särskilja begreppen rent ämne och blandning. Övningar gjordes i början av kursen. I slutet av kursen fick de svara på fem frågor om massans bevarande med vardaglig koppling.

Det var ca 50 % som fick alla rätt på de fem frågorna, vilket är något bättre än 34 % hos gruppen som inte fick någon särskild undervisning om materiens partikelnatur och massans bevarande. En viss ökning i förståelse för skillnaden mellan begreppen rent ämne och blandning kunde urskiljas i deras tentamenssvar, men detta behöver undersökas i större omfattning för att kunna bekräftas.

Det är viktigt att undervisa studenter inom natur- och ingenjörsvetenskapliga utbildningar om begreppen materiens partikelnatur, massans bevarande, rent ämne och blandning. Annars kan dessa kunskapsbrister begränsa deras möjligheter att kunna lära sig mer avancerade koncept inom naturvetenskapen. Detta är särskilt viktigt för lärosäten som satsar på breddad rekrytering eftersom undervisningen inom naturvetenskap kan begränsas eller prioriteras bort för elever som följer en anpassad timplan till förmån för ämnen som krävs för gymnasiebehörighet.
Implementation Of Customer Relationship Management In Order To Build Customer Satisfaction And Loyalty
Authors: Fauziyyah Salma , Khusna Khanifatul
Published: May 2022

This study aims to examine the impact of the implementation of customer relationship management (CRM) on customer satisfaction and loyalty, and the impact of satisfaction on customer loyalty of government commercial banks (BNI, BRI, Bank Mandiri, and BTN) in East Java Province. The research instrument used was a questionnaire. The research covered employees, technology, sales, products, and performance. The population of this study is all depositors of government commercial banks (BNI, BRI, Bank Mandiri, and BTN) in East Java Province. The sampling method uses purposive sampling with a total sample of 120 respondents taken in three locations in three cities in the East Java region, namely: Jember City represents a small town, Malang City represents a medium city, and Surabaya City represents a large city. The allocation of the number of samples for each bank and each city is carried out proportionally. Data analysis models use Structural Equation Modelling (SEM). The analysis shows that CRM has a significant positive effect on customer satisfaction and loyalty, and customer satisfaction has a significant positive effect on customer loyalty.
Keywords — customer relationship management, customer satisfaction, customer loyalty
Consumer Empowerment Index in the Telecommunications Sector: The Role Of Socio-Demographic and Lifestyle
Authors: Eka Putri Riska Rahma , Simanjuntak Megawati
Published: May 2022

Consumer empowerment is a benchmark for business, especially in the telecommunications sector, for economic fundamentals. This study aims to analyze the effect of social, demographic and economic characteristics and lifestyles on consumer empowerment in the telecommunications sector. This study applied a cross-sectional study with data collection by online survey. Cluster analysis and logistic regression were used to analyze 100 data. The results showed that consumer empowerment in the telecommunications sector was still relatively low. The average level of consumer empowerment in the telecommunications sector was 51.61, including the capable category. Based on dimensions, the index of information seeking was 80.8, knowledge of laws and consumer protection institutions was 52.8, service selection was 63.8, usage behavior was 71.0, tendency to talk was 43.7, and complaint behavior was 27.7. The full-filled lifestyle had a significant negative effect on consumer empowerment in the telecommunications sector. Thus, respondents who had a lifestyle other than a fulfilled lifestyle had more opportunities to be empowered than a fulfilled lifestyle. This research is a breakthrough in the study of thematic consumer empowerment, so it needs to be developed in the future.
Keywords—Consumer Empowerment; Demographics; Economic; Lifestyle; Social
Abordagem global do paciente queimado: uma revisão de literatura
Authors: Morais Maria Eduarda Ferreira Felga , Bullos Bernardo Silva , Bullos Bruno Silva , Morais Maria Isabel Ferreira Felga , Maia Lucineide Martins de Oliveira
Published: May 2022

Objetivo: Avaliar de forma global, os aspectos inerentes ao paciente grande queimado, bem como os principais equívocos de condução emergencial do tratamento desses enfermos. Revisão Bibliográfica: Ao longo deste artigo, verificou-se que para que haja um tratamento efetivo, alguns fatores devem ser individualizados como o diagnóstico precoce caracterizado pela identificação da etiologia, extensão, gravidade e profundidade das lesões causadas por queimaduras. A partir desses aspectos torna-se imprescindível disseminar a informação quanto ao tratamento da equipe multiprofissional em prol da retomada da qualidade de vida do paciente assolado com tal condição clínica. Considerações finais: Diante do exposto, visando aumentar a contribuição para a comunidade médica, a presente revisão de literatura resumiu-se na elucidação dos principais erros frente ao paciente queimado. Em uma análise epidemiológica dos casos, infere-se que apenas o tratamento multidirecionado é capaz de proporcionar a resolubilidade do quadro, aspecto este que não é visualizado em grandes centros de emergência em atendimento de pacientes traumatizados.
Remote patient monitoring in spine surgery
Authors: Farias Frederico A. C. , Falavigna Vincenzo F. , Viapiana Maria Eduarda L. , Falavigna Asdrubal
Published: May 2022

Objectives:

Remote monitoring or telemonitoring is an innovative strategy to improve patient care. This study aimed to present the authors’ experience of a remote monitoring platform for post-operative care of patients who have undergone spine surgery.

Methods:

A telemonitoring system for patients undergoing spine surgery, centered on a smartphone application named Wippe Track, (Brazilian Telemedicine Company BR HomMed, São Paulo, Brazil) compatible with both Android and iOS smartphones. All patients had two Bluetooth devices connected to the smartphone application: Digital scale and wristband activity tracker. The outcomes evaluated were based on patient-related outcome measures (PROMs) using specific disease-oriented questionnaires.

Results:

A preliminary study to refine the system based on patient/provider input was performed with 30 patients. The adherence and interaction with the platform were 94%. Patients have provided all the PROMs data inputs and have consistently interacted with monitoring center professionals and the surgeon through the platform. Weight loss was observed in 76% of overweight patients using remote nutritionist support and specific exercises.

Conclusion:

The patients were satisfied and felt secure. The remote monitoring could detect and help manage events and warnings related to post-operative issues and reduce the need to travel for non-scheduled care.
Brain overgrowth associated with megalencephaly-capillary malformation syndrome causing progressive Chiari and syringomyelia
Authors: Deleu Tom , Jansen Katrien , Calenbergh Frank Van
Published: May 2022

Background:

Megalencephaly-capillary malformation (M-CM) syndrome is a rare overgrowth syndrome characterized by macrocephaly, port-wine stains, asymmetric brain growth, hydrocephalus, and developmental delay. Cerebellar tonsil herniation is often seen, but rarely with syringomyelia.

Case Description:

A newborn with M-CM syndrome developed a progressive Chiari malformation type I (CM-I) with syringomyelia. At 4 months, he was treated for subdural hematomas, while at 10 months, he required a shunt for hydrocephalus. At 16 years of age, he newly presented a left hemiparesis and ataxia. Notably, successive volumetric measurements of the posterior fossa/cerebellum showed disproportionate cerebellar growth over time that correlated with the appearance of a CM-I. Following a suboccipital craniectomy with C1-laminectomy and duraplasty, he neurologically improved.

Conclusion:

M-CM with CM-I and syringomyelia rarely present together. Here, we treated an infant with M-CM who developed a progressive CM-I malformation and syringomyelia reflecting disproportionate growth of the cerebellum/posterior fossa over a 16-year period.
Clinical outcome and safety of stem cell therapy for ischemic stroke: A systematic review and meta-analysis
Authors: Permana Andhika Tomy , Bajamal Abdul Hafid , Parenrengi Muhammad Arifin , Suroto Nur Setiawan , Lestari Pudji , Fauzi Asra Al
Published: May 2022

Background:

Several reports on stem cell administration have emerged proving it to be an ideal therapeutic approach for improving neurological functions in ischemic stroke patients. However, some studies also show disappointing results, with some reporting no statistically significant improvements among several different parameters. Several challenges also arise relating to safety and nonscientific aspects, such as ethics.

Methods:

We performed a systematic review and meta-analysis to evaluate the effect of stem cell therapy on the clinical outcomes of ischemic stroke patients. A systematic review and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A thorough literature search was conducted on PubMed, Scopus, and Cochrane databases. Articles were selected systematically based on the PRISMA protocol and reviewed completely. A total of 19 publications pertaining to stem cell therapy on the ischemic route were included and reviewed. Efficacy outcomes were measured with the National Institutes of Health Stroke Scale, modified Rankin Scale, or Barthel Index.

Results:

The results of the meta-analysis indicate that the efficacy outcomes suggest favorable results after stem cell therapy, although not all study results are statistically significant. Stem cell therapy in stroke cases showed a better outcome than standard conservative therapy alone, although our analysis shows that many factors can influence this outcome, and significant effects can only be seen after several months.

Conclusion:

The results of this study show promising and satisfying efficacy and a relatively low rate of serious adverse events.
STRUCTURE OF TRAUMATIC INJURIES AND EXPERIENCE IN THE TREATMENT OF THE WOUNDED PATIENTS, AS A RESULT OF HOSTILITIES IN THE FIRST DAYS OF RUSSIA’S ATTACK ON UKRAINE
Authors: DENYSIUK M.V , DUBROV S. , CHERNIAIEV S. , SEREDA S. , ZAIKIN YU.M
Published: May 2022

Introduction. All the gunshot wounds are of high-energy. Gunshot and blast injuries, in most cases, are multiple, varying in depth and area of the wound surface. From the first day of the full-scale invasion of Russian troops (February 24, 2022), many victims of hostilities on the right bank of the Dnipro river in Kyiv were hospitalized in our hospital, which is one of the clinical bases of the Department of Anesthesiology and Intensive Care of the Bogomolets National Medical University. Dozens of wounded patients needed simultaneous interventions, and the presence of only 5 operating tables in the facility did not prevent the provision of appropriate qualified medical care to 6-8 critical patients at the same time.

The goal of the work. To determine the structure and severity of traumatic injuries received as a result of hostilities.

Materials and methods. In the study a prospective analysis of 89 patients who were injured in hostilities for the period from February 24 and March 3 2022, and were hospitalized in one of the clinical bases of the Department of Anesthesiology and Intensive Care of the Bogomolets National Medical University was conducted.

Results and discussion. Lesions of one anatomical area occurred in 54 people (60.7%), lesions of two or more anatomical areas – in 35 people (39.3%). Most injured patients – 61 (68.5%), required from 2 to 6 surgeries, which was due to damage to various anatomical areas or the need for phased surgical interventions, including the use of damage-control surgery. Of the 66 patients with limb and pelvic bone injuries, mine explosions or gunshot fractures of the long bones of arms and legs, 41 were injured, and all were treated on an orthopedic basis. Damage-control surgery for injuries of abdominal organs was used in 5 wounded patients. In two patients, damage-control surgery was used for injuries of the pleural cavity. 9 patients (10.1%) of the 89 hospitalized with traumatic injuries received as a result of hostilities died.

Conclusion. Extremities and pelvic bones injuries dominate in the structure of combat injuries – 66 (43.7%) patients; chest injuries were in 31 (20.5%) patients; head and neck injuries in 27 (17.9%) patients; abdominal solid organs and pelvic organs injuries in 19 (12.6%) patients; facial injuries in 8 (5.3%) patients. Damage of two or more anatomical areas occurred in 39.3% of patients affected by the hostilities. Most of the wounded patients – 68.5%, required from 2 to 6 surgeries.
PREVENTION OF PULMONARY COMPLICATIONS IN THORACIC ANESTHESIOLOGY
Authors: SYDIUK O.E. , SYDIUK A
Published: May 2022

Introduction. Pulmonary complications are one of the most common after surgery on the thoracic cavity. Although the incidence of pulmonary complications is gradually decreasing, recent studies have shown that they still occur in 26% -38% of cases. Pulmonary complications are also a major cause of hospital mortality and may be an independent risk factor for worse long-term survival [1, 2, 3].

The goal of the work. Therefore, the aim of the work was to improve the results of treatment of patients after thoracic surgery by developing an algorithm for anesthesia for perioperative prevention of pulmonary complications.

Materials and methods. The study was performed on 192 patients with diseases of the thoracic cavity (esophagus, lungs, mediastinum), underwent surgery in the thoracoabdominal department of the Shalimov’s National Institute of Surgery and Transplantation. Retrospective control group – 96 patients after thoracic surgery, which used conventional methods of perioperative management. The study group – 96 patients after thoracic surgery, which used perioperative anesthesia algorithm for the prevention of pulmonary complications. Statistical software EZR v. 1.54 was used for statistical calculations (graphical user interface for statistical software R version 4.0.3, R Foundation for Statistical Computing, Vienna, Austria).

Results and discussion. One-factor analysis revealed a relationship (p = 0.001) of the risk of complications with the method of prevention of pulmonary complications. When conducting a multifactor analysis, it was found that the proposed method of prevention of pulmonary complications can reduce (p = 0.001) the risk of development, HR = 0.27 (95% CI 0.13-0.58) compared with the control group (with standardization by sex, weight, ASA of the patient). Pulmonary complications developed in 33 (34.4%) patients of the control group and in 13 (13.5%) patients of the study group, the difference was statistically significant, p = 0.001. Thus, the use of the proposed technique reduces (p = 0.001) the risk of complications, HR = 0.39 (95% CI 0.22 - 0.70) compared to traditional methods.

Conclusions. Thus, the developed algorithm for the prevention of pulmonary complications after thoracic surgery has significantly improved the results of surgical treatment of patients by reducing the number and reducing the risk of these complications by 2.5 times (from 34.4% in patients in the control group to 13.5% in patients in the study group).
Strategi Pengembangan Sumberdaya Manusia Dalam Meningkatkan Kinerja Aparatur Pada Badan Kepegawaian Dan Pengembangan Sumber Daya Manusia Kabupaten Sarmi
Authors: Muarsarsar Sidwas
Published: May 2022

Strategies that can be carried out by organizations in improving the performance of their apparatus/employees include increasing human resource development. The purpose of this study was to identify and analyze human resource development strategies, supporting and inhibiting factors of human resource development strategies in improving the performance of the apparatus at the Agency for Personnel and Human Resources Development in Sarmi Regency. The research method uses a qualitative approach, data collection techniques are observation, interviews, and documentation. The results of this study are: 1) The strategy for developing human resources at the BKPSDM in Sarmi Regency has not run optimally and effectively based on the findings, as follows: a) Increasing the development of the apparatus formally and informally is not good b) Increasing the career development of the apparatus, namely providing promotions to employees who excel, not well implemented, c) Improvement of the Merit System in Employee Management, namely placing employees according to the field and background of the employee's discipline is lacking well implemented 2) Supporting and inhibiting factors (a) Supporting factors: Availability of legal protection, external support such as Corporate Social Responsibility assistance or scholarships, availability of training institutions, educational institutions, availability of budgetary resources, human resources, and facilities (b) Inhibiting factors: limited budget, limited personnel/human resources, supporting facilities for human resource development are limited and inadequate, weak supervision, low level of employee welfare.
Unijna pomoc w rozwoju gospodarki w pierwszych latach członkostwa Polski w Unii Europejskiej
Authors: Ślusarczyk Zenon
Published: May 2022

Na przełomie lat osiemdziesiątych i dziewięćdziesiątych XX wieku przeprowadzono szereg reform w polityce spójności Unii Europejskiej. Polska blisko już członkostwa w UE rozpoczęła negocjacje z instytucjami unijnymi w sprawie korzystania z funduszy Wspólnoty w celu redukcji różnic w rozwoju gospodarczym oraz innowacyjności, by sprostać wyzwaniom w funkcjonowaniu jednolitego rynku. W efekcie Polska otrzymała duże wsparcie z funduszy unijnych. Celem artykułu jest analiza pomocy UE w rozwoju gospodarki Polski w pierwszych latach członkostwa w Unii Europejskiej i udowodnienie hipotezy, że przystąpienie Polski do Unii oraz korzystanie z jej pomocy w ramach polityki spójności przyczyniło się do rozwoju i modernizacji naszej gospodarki. Proces ten nadal jest kontynuowany głównie w odniesieniu do rosnących wyzwań związanych z globalizacją, a także wprowadzaniem nowych technik i technologii w gospodarce.
Ochrona własności intelektualnej w innowacyjnych przedsiębiorstwach. Wybrane problemy
Authors: Ślusarczyk Zenon
Published: May 2022

Innowacyjność (nowoczesność) w tworzeniu i funkcjonowaniu przedsiębiorstw, tworzenie i wdrażanie nowych technologii w produkcji i usługach, podnoszenie wiedzy pracowników itp. to obecnie podstawowe aspekty unowocześnienia gospodarki i sprostania konkurencji w warunkach globalnego rynku. Polskie przedsiębiorstwa różnią się w swych podejściach i umiejętnościach tworzenia oraz pozyskiwania nowych technologii i ich wdrażania. Również proces i skala transferu nowoczesnych technologii ma zróżnicowany charakter. Stosowane są różne kanały i formy w tym zakresie, co komplikuje kwestie ochrony własności intelektualnej. Problem ochrony własności intelektualnej jest obecnie złożony, wieloaspektowy, zwłaszcza w kontekście wszechstronnego wykorzystywania mediów elektronicznych. Wymaga to odpowiednich regulacji prawnych i właściwego ukierunkowania działań edukacyjnych firm. Celem artykułu jest analiza wybranych aspektów ochrony własności intelektualnej w innowacyjnych przedsiębiorstwach. Zdaniem autora obecnie zasadniczy wpływ na zachowania ludzi wywierają współczesne media. Potrzeba dobrego rozeznania źródeł, z których korzystają media, zwłaszcza elektroniczne, w zakresie nowych technologii. Jest to szczególnie istotne dla przedsiębiorstw nastawionych na rozwój działań B+R i przestrzeganie w tym kontekście odpowiednich przepisów o ochronie własności intelektualnej.
Znaczenie sztucznej inteligencji w działalności przedsiębiorstw. Podstawowe informacje
Authors: Ślusarczyk Zenon
Published: May 2022

W przedsiębiorstwach rozwój i stosowanie sztucznej inteligencji wiążą się z ich kulturą organizacyjną, zarządzaniem zasobami ludzkimi i wiedzą. Chodzi o większe zaangażowanie i aktywność pracowników we wdrażanie i rozwój sztucznej inteligencji, co sprzyja podnoszeniu poziomu ich innowacyjności i efektywności działań, a także o przestrzeganie odpowiednich przepisów prawnych i regulaminów. Wiąże się to ze współczesnymi aspektami aspiracji, motywacji oraz dążeń pracowników i menedżerów. Duży wpływ na ich wiedzę, zachowania i innowacyjne pomysły mają media, ich zróżnicowanie i charakter. Obecnie wiedza medialna jest rozległa, ale często powierzchowna. Internet stał się najczęściej używanym medium do wyrażania swoich poglądów, opinii i pomysłów, a zarazem obiektem częstych cyberataków. Potrzebna jest więc ochrona właściwych informacji przedsiębiorstw, a także danych osobowych informatorów i użytkowników. Ma temu sprzyjać rozwijająca się komunikacja wewnątrz i na zewnątrz przedsiębiorstwa. Podjęty w artykule temat jest obszerny, wieloaspektowy i ulega zmianom, dlatego też autor zaznacza, iż prezentuje podstawowe informacje przydatne między innymi w kontekście skutków pandemii.
Efektywne zarządzanie czasem w połączeniu pracy zawodowej i studiów na uczelni wyższej
Authors: Głowienka Weronika
Published: May 2022

W obecnym świecie dobra organizacja czasu to podstawa. Ludzie mają coraz więcej obowiązków, a doba wciąż trwa jedynie dwadzieścia cztery godziny. Aby wypełnić wszystkie cele na daną jednostkę czasu, należy odpowiednio zarządzać swoim czasem, co nie jest łatwe. W części teoretycznej opracowania omówione zostało pojęcie zarządzania czasem. Przedstawiono najprostszą definicję zarządzania czasem oraz jedną z głównych metod zarządzania czasem. Dodatkowo przybliżono zasadę Pareto oraz prawo Parkinsona. W części empirycznej zostały opracowane wyniki badania przeprowadzonego za pomocą autorskiego kwestionariusza ankietowego. Badanie skierowane było do studentów aktywnych zawodowo. Po przeanalizowaniu struktury odpowiedzi na wybrane pytania sformułowane zostały wnioski. Większość studentów ocenia swoją umiejętność zarządzania czasem jako dobrą oraz widzi jej poprawę, od kiedy połączyli studia i pracę. Studenci uważają również, że łączenie studiów i pracy zawodowej jest trudne i wymaga dobrej organizacji. Dodatkowo jako metodę badawczą wykorzystano doświadczenie autora, aktywnego zawodowo studenta trzeciego roku studiów pierwszego stopnia na Uniwersytecie Przyrodniczym w Lublinie.
Diversity in a Bottle: Iminium Ions as a Platform for N-(Hetero)Aryl Piperidine Synthesis
Authors: Greenwood Jacob , Larsen Matthew , Burgess Samantha , Newman Justin , Jiang Yuan , Sather Aaron C.
Published: May 2022

Piperidines are prevalent throughout FDA-approved drugs and current drug candidates, thus robust methods for preparing these heterocycles are desirable for efficiently probing structure activity relationships (SAR) during drug discovery campaigns. N-heteroaryl piperidines are particularly important in pharmaceutical applications, but they remain problematic synthetic targets because traditional approaches based on transition metal catalyzed cross-coupling and or SNAr reactions routinely fail. We report here a general platform for the rapid synthesis of densely functionalized N-(hetero)aryl piperidine derivatives using a common precursor. First, we disclose an expeditious synthesis of bench-stable cyclic iminium salts starting from widely abundant heteroaryl amine and ketoacrylate feedstocks. We then show that these intermediates are readily elaborated into a wide variety of complex piperidines via derivatization reactions employing common reagents. This chemistry facilitates incorporation of trifluoromethyl, methyl, and cyano nucleophiles at C2, in addition to substitution at C3 using a variety of carbon electrophiles. Additionally, sequential C3 and C2 functionalization of the iminium salts allows for modular construction of piperidine derivatives having very complex substitution patterns. Finally, we show that the key iminium species can be generated and transformed in situ, providing access to desired compounds in a single-pot through-process.
Active Learning for Small Molecule pKa Regression; a Long Way To Go
Authors: Francoeur Paul , Penaherrera Daniel , Koes David
Published: May 2022

The immense size of chemical space, the relative scarcity of high quality data, and the cost of running experiments to accurately measure molecular properties makes active learning (AL) an attractive approach to efficiently explore the space and train high-quality models for molecular property prediction. While AL is traditionally successful at classification, there have been recent advances in using AL for regression tasks. Recently, regressing to a normal inverse gamma distribution has been shown to be effective at predicting molecular properties in the QM9 dataset. However, we present a series of experiments demonstrating that various state of the art AL regression techniques are indistinguishable from random selection for small molecule pKa prediction. Source code for this paper is available at https://github.com/francoep/pKa_activelearning.
Thiocyanate Ions Form Antiparallel Populations at the Concentrated Electrolyte / Charged Surfactant Interface
Authors: Kumal Raju R. , Wimalasiri Pubudu N. , Servis Michael , Uysal Ahmet
Published: May 2022

Anions play significant roles in the separation of lanthanides and actinides. The molecular-scale details of how these anions behave at aqueous interfaces are not well understood, especially at high ionic strengths. Here, we describe the interfacial structure of thiocyanate anions at a soft charged interface up to 5 M bulk concentration with combined classical and phase-sensitive vibrational sum frequency generation (PS-VSFG) spectroscopy, and molecular dynamics (MD) simulations. At low concentrations thiocyanate ions are mostly oriented with their sulfur end pointing towards the charged surfactants. VSFG signal reaches a plateau around 100 mM bulk concentration, followed by significant changes above 1 M. At high concentrations a new thiocyanate population emerges with their sulfur end pointing towards the bulk liquid. The -CN stretch frequency is different for up and down oriented SCN- ions, indicating different coordination environments. These results provide key molecular-level insights for the interfacial behavior of complex anions in highly concentrated solutions.
Synthesis and styrene copolymerization of novel fluoro, methoxy and methyl ring-disubstituted octyl phenylcyanoacrylates
Authors: Awadallah Mahmoud D. , Awan Izza A. , Carlino Grace M. , Cherian Zachary K. , Dimonte Sophia J. , Purkey Madeline A. , Rabelas Juvy L. , Singapori Yash Y. , Syeda Bajeel , Wisniewski Victoria J. , Rocus Sara M. , Schjerven William S. , Kharas Gregory B
Published: May 2022

Novel fluoro, methoxy, and methyl ring-disubstituted octyl phenylcyanoacrylates, RPhCH=C(CN)CO2CH2(CH2)6CH3 (where R is 2-fluoro-3-methoxy, 2-fluoro-4-methoxy, 2-fluoro-5-methoxy, 2-fluoro-6-methoxy, 3-fluoro-4-methoxy, 4-fluoro-3-methoxy, 2-fluoro-5-methyl, 2-fluoro-6-methyl, 3-fluoro-4-methyl, 4-fluoro-2-methyl, 4-fluoro-3-methyl) were prepared and copolymerized with styrene. The acrylates were synthesized by the piperidine catalyzed Knoevenagel condensation of ring-disubstituted benzaldehydes and octyl cyanoacetate, and characterized by CHN analysis, IR, 1H and 13C NMR. All the acrylates were copolymerized with styrene in solution with radical initiation (ABCN) at 70C. The compositions of the copolymers were calculated from nitrogen analysis.
RNA polymerisation without catalyst from 2’,3’-cyclic nucleotides by drying at air-water interfaces
Authors: Dass Avinash Vicholous , Wunnava Sreekar , Langlais Juliette , von der Esch Beatriz , Krusche Maik , Ufer Lennard , Chrisam Nico , C. A. Dubini Romeo , Gartner Florian , Angerpointner Severin , F. Dirscherl Christina , Rovó Petra , B. Mast Christof , Šponer Judit , Ochsenfeld Christian , Frey Erwin , Braun Dieter
Published: May 2022

For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step. We found alkaline, uncatalysed drying conditions in bulk and at heated air-water interfaces where 2´,3´-cyclic nucleotides polymerised, forming up to 10-mers within a day. The polymerisation proceeded at a pH range of 7-12 at temperatures between 40-80 °C and was marginally enhanced by K+ ions. Among the canonical ribonucleotides, cGMP polymerised most efficiently. Quantification was performed using HPLC coupled to ESI-TOF by fitting the isotope distribution to the mass spectra. Our study suggests a polymerisation mechanism where cGMP aids the incorporation of the relatively unreactive nucleotides C, A and U. The 2´,3´-cyclic nucleotides are byproducts of prebiotic phosphorylation, nucleotide syntheses and RNA hydrolysis, indicating direct recycling pathways. The simple reaction condition offers a plausible entry point for RNA to the evolution of life on early Earth.
Optoelectronic devices and methods for studying combustion and explosion processes
Authors: Rubtsov Nickolai , Alymov Mikhail , Kalinin Alexander , Vinogradov Alexey , Rodionov Alexey , Troshin Kirill
Published: May 2022

The main objective of this book is to acquaint the reader with the main modern problems of the multisensor data analysis and opportunities of the hyperspectral shooting being carried out in the wide range of wavelengths from ultraviolet to the infrared range, visualization of the fast combustion processes of flame propagation and flame acceleration, the limit phenomena at flame ignition and propagation. The book can be useful to students of the high courses and scientists dealing with problems of optical spectroscopy, vizualisation, digital recognizing images and gaseous combustion. The main goal of this book is to bring to the attention of the reader the main modern problems of multisensory data analysis and the possibilities of hyperspectral imaging, carried out in a broad wave-length range from ultraviolet to infrared by methods of visualizing fast combustion processes, propagation and flames acceleration, and limiting phenomena during ignition and flame propagation. The book can be useful for students of higher courses and experimental scientists dealing with problems of optical spectroscopy, visualization, pattern recognition and gas combustion.
ПІДВИЩЕННЯ ЕФЕКТИВНОСТІ ПРОЦЕСУ ФІЗИЧНОГО ВИХОВАННЯ ШКОЛЯРІВ СУЧАСНИМИ ФІТНЕС-ТЕХНОЛОГІЯМИ
Authors: Тищенко В. О. , Омельяненко Г. А. , Крюков Ю. М. , Яковченко А. B.
Published: May 2022

На сьогодні перспективним напрямом у вирішенні проблеми підвищення ефективності процесу фізичного виховання підростаючого покоління є використання в цьому процесі таких видів спортивної діяльності, як Тай-КІК, який користується великою популярністю серед молоді. В учнів старшого шкільного віку простежується тенденція до зниження бажання займатися фізичними вправами, особливо на уроках фізичної культури. Тому слід розширювати секційні заняття, на яких учням надається можливість займатися тими спортивними вправами, які їм цікаві, від яких вони отримують задоволення. Мета дослідження – розробити та апробувати програму фізичного виховання школярів із використанням засобів Тай-КІК для підвищення рівня їхнього фізичного стану. Об’єкт дослідження – процес фізичного виховання. Методи дослідження – аналіз та узагальнення літературних джерел за темою дослідження, педагогічні спостереження, методи оцінки функціонального стану серцево-судинної системи і системи зовнішнього дихання, методи математичної статистики. Методи дослідження: теоретичний аналіз і узагальнення літературних джерел (проведено пошук інформації та з’ясування обґрунтованості наукової проблематики дослідження); педагогічне тестування (встановлено показники функціонального стану серцево-судинної системи і системи зовнішнього дихання); методи математичної статистики (використано для опрацювання емпіричних даних на етапах дослідження). Результати дослідження. На початковому етапі дослідження вихідні значення показників фізичного стану дівчат старшого шкільного віку досліджуваних груп не мали статистично вірогідної різниці. Під впливом впровадження програми із застосуванням засобів Тай-КІК прикінцеві результати тестування функціонального стану серцево-судинної системи відповідали високому і середньому рівням, функціонального стану системи зовнішнього дихання класифікувалися як вище за середній й середній. Висновки. Доведено, що використання засобів Тай-КІК в процесі фізичного виховання дівчат старшого шкільного віку сприяло істотній оптимізації функціонального стану серцево-судинної системи і системи зовнішнього дихання та фізичного стану обстежених школярок. Результати дослідження рекомендовані для практичного використання в системі фізичного виховання дітей шкільного віку.
АНАЛІЗ ТЕХНІКО-ТАКТИЧНИХ ДІЙ ЗБІРНИХ КОМАНД З ГАНДБОЛУ НА ОЛІМПІАДІ 2020
Authors: Тищенко Д. Г. , Болілий О. С. , Соколова О. В.
Published: May 2022

Дослідження присвячене аналізу кидків м’яча по воротах кваліфікованими гандболістами на Олімпіаді 2020 року, оцінюється їх зв’язок із результатами команди. Зосереджено на результативності команди на основі офіційної статистики. Мета дослідження – дослідити ефективність виконання кидків м’яча по воротах із різних ігрових позицій кваліфікованими гандболістами на Олімпіаді 2020 року. Об’єкт дослідження – кидки м’яча по воротах із різних ігрових позицій, як елемент техніко-тактичних дій кваліфікованих гандболістів на Олімпіаді 2020 року. Предмет дослідження – виконання кидків м’яча по воротах з різних ігрових позицій кваліфікованими гандболістами на Олімпіаді 2020 року. Результати дослідження. Вивчення об’єктивних показників ефективності та їх зв’язку з результатом команди може бути корисним тренерам для оцінки різних особливостей гри в гандбол, контролю показників фізичної підготовки та техніки спортсменів, оскільки надають цінну та об’єктивну інформацію для оцінки матчу. Тому показники ефективності можна використовувати для контролю та оцінки конкуренції. Видається необхідним проведення подальших експериментів у цьому напрямку для аналізу граничних точок, що встановлені в цьому дослідженні в інших змаганнях і категоріях, і створення конкретної моделі для оцінки як команди, так і гравців на різних етапах матчу. Збір даних про індивідуальні та командні результати може привести до інтегративної моделі для пояснення успіху команди.
Present Strategy for REBOA Management After Catheter Placement: A Current Suggestion From the Japanese Society of DIRECT
Authors: Kurihara Yutaro , Tamura Satoshi , Maruhashi Takaaki , Matsumura Yosuke
Published: May 2022

Resuscitative endovascular balloon occlusion of the aorta (REBOA) has been accepted as a useful bridging tool to definitive hemostasis in refractory hemorrhagic shock. Although there is insufficient evidence of the target blood pressure under the utilization of REBOA, it may be reasonable to avoid excessive blood pressure elevation. Invasive blood pressure monitoring proximal to the aortic occlusion is desirable during REBOA. The zone of the aorta is selected and changed according to the location of injuries and the physiological conditions. The key to successful REBOA management is to set up an independent REBOA coordinator for systemic management. This review article aims to explain the procedures of proper REBOA management, so as to fill the knowledge gap between educational courses, which highlight the indications and safe procedures of the device, and the critical settings faced in clinical practice.
Affective Brain-Computer Music Interface in Emotion Regulation and Neurofeedback: A Research Protocol
Authors: Glassman Harley , Dwyer Daniel , John Nicia , Laesker Denis , So Matthew
Published: May 2022

Introduction: Emotion regulation is an integral part of mental health, dynamically impacting brain function as one’s emotions change continuously throughout the day. Impairments in emotion regulation are associated with a range of psychiatric disorders. Although the implications of emotion regulation are crucial to mental health, few studies have examined training emotion regulation strategies with respect to the brain. Thus, this manuscript will propose an affective brain-computer music interface (aBCMI) prototype for emotion regulation that continuously generates music by estimating emotions from real-time electroencephalography (EEG) signals.
Methods: In this proposal, we describe our prototype consisting of an emotion classifier that detects the expression of emotions from EEG signals, and a music generator that generates music reflective of those emotions. We evaluate the prototype in three separate studies. In study 1, the accuracy of the music generator is tested. In study 2, the accuracy of the emotion classifier is tested by assessing its correlation with real-time, self-reported emotions. In study 3, the generative music algorithm is assessed to explore emotion regulation strategies.
Discussion: The proposed BCMI is expected to accurately estimate emotions, provide musical feedback of participants’ emotions, and enable users to intentionally modulate their emotions from musical feedback. This involves capturing the listener’s emotions in real-time using EEG signals, providing the opportunity to regulate one’s emotional state with musical feedback. Thus, in addition to enabling greater neurofeedback training of emotions, our prototype can enhance the understanding of affective computing and emotions with EEG and machine learning.
Conclusion: Clinical applications of this prototype may have a tremendous impact as a neurofeedback tool in music therapy for training emotion regulation. Future research may benefit from using the proposed BCMI as a neurofeedback treatment in mood disorders.
Changing Freshwater Management in New Zealand
Authors: Joy Mike
Published: May 2022

Freshwater management policy in New Zealand is currently undergoing major upheaval. It is abundantly clear that the existing policy failed its stated goal, to protect freshwaters for future generations. Therefore, this is a crucial time to look back and see where policy failed so we can avoid repeating the same mistakes. The implementation failures included setting inadequate objectives, failing to monitor outcomes, and failing to adequately enforce even those compromised objectives. Furthermore, there were policy shortcomings, revealed by an almost total failure to deal with the diffuse nature of the biggest environmental impacts.
A Review of Current Regional-Level Environmental Monitoring
Authors: Fischer Shelley
Published: May 2022

Environmental monitoring helps us take stock of our natural environment. Clear, coordinated and consistent regional-level monitoring and reporting are required to assess the state of our environment and protect important sociocultural and economic assets. This article reviews and summarises the key issues affecting regional-level environmental monitoring, reporting and enforcement in Aotearoa New Zealand. These include weak legislation, lack of independent monitoring, patchy data coverage, misuse and distortion ofdata, insecure funding and inappropriate political interference. Solutions include legislative reform, consolidation of funding and centralisation of some roles, and establishing a centralised research council.
From Lines to Circles: reshaping waste policy
Authors: Blumhardt Hannah , Prince Liam
Published: May 2022

The impacts of waste transcend landfills and litter; emissions and pollution occur at every stage of the linear ‘take–make–waste’ economy. Zero waste and circular economy theories offer systemic perspectives and practical solutions. The New Zealand government has committed to a circular economy vision for Aotearoa. Given New Zealand’s ‘rubbish record on waste’, the social and economic transformation required will take extraordinary collaboration and a common direction of travel. This article diagnoses the extent of global waste problems, the circular pathways forward, and New Zealand’s early steps along them. With the government re-oriented to act, we urge an ambitious, joined-up approach that avoids locking in inadequate responses to existential threats.
Assessment of mortality and hospital admissions associated with confirmed infection with SARS-CoV-2 Alpha variant: a matched cohort and time-to-event analysis, England, October to December 2020
Authors: Dabrera Gavin , Allen Hester , Zaidi Asad , Flannagan Joe , Twohig Katherine , Thelwall Simon , Marchant Elizabeth , Aziz Nurin Abdul , Lamagni Theresa , Myers Richard , Charlett André , Capelastegui Fernando , Chudasama Dimple , Clare Tom , Coukan Flavien , Sinnathamby Mary , Ferguson Neil , Hopkins Susan , Chand Meera , Hope Russell , Kall Meaghan ,   on behalf of the  COG-UK Consortium
Published: May 2022

Background

The emergence of the SARS-CoV-2 Alpha variant in England coincided with a rapid increase in the number of PCR-confirmed COVID-19 cases in areas where the variant was concentrated.

Aim

Our aim was to assess whether infection with Alpha was associated with more severe clinical outcomes than the wild type.

Methods

Laboratory-confirmed infections with genomically sequenced SARS-CoV-2 Alpha and wild type between October and December 2020 were linked to routine healthcare and surveillance datasets. We conducted two statistical analyses to compare the risk of hospital admission and death within 28 days of testing between Alpha and wild-type infections: a matched cohort study and an adjusted Cox proportional hazards model. We assessed differences in disease severity by comparing hospital admission and mortality, including length of hospitalisation and time to death.

Results

Of 63,609 COVID-19 cases sequenced in England between October and December 2020, 6,038 had the Alpha variant. In the matched cohort analysis, we matched 2,821 cases with Alpha to 2,821 to cases with wild type. In the time-to-event analysis, we observed a 34% increased risk in hospitalisation associated with Alpha compared with wild type, but no significant difference in the risk of mortality.

Conclusion

We found evidence of increased risk of hospitalisation after adjusting for key confounders, suggesting increased infection severity associated with the Alpha variant. Rapid assessments of the relative morbidity in terms of clinical outcomes and mortality associated with emerging SARS-CoV-2 variants compared with dominant variants are required to assess overall impact of SARS-CoV-2 mutations.
Якість життя населення, яке постраждало від військових дій
Authors: Bielikova Nataliia , Indyka Svitlana , Tsos Anatolii , Vashchuk Liudmyla
Published: May 2022

Актуальність. В умовах військового втручання постає завдання краще зрозуміти людські наслідки збройного конфлікту. Вплив травмуючих подій війни може призвести до зниження якості життя населення на багато років навіть після закінчення реальних бойових подій. Розуміння механізмів впливу факторів ризику може сприяти розробці більш ефективних стратегій втручання в післявоєнних умовах. Мета дослідження: здійснити аналіз впливу іноземних військових інтервенцій, що відбувалися у минулому, на короткотривалу і довготривалу якість життя населення, якого безпосередньо торкнулася війна. Методи досліджень. У дослі- дженні використовувався метод теоретичного аналізу й узагальнення інформації електронних баз даних. Результати дослідження. Війна впливає на самооцінку здоровʼя, фізичні здібності, емоційне та психічне здоровʼя всього населення, втягнутого у військовий конфлікт. Серед предикторів зниження якості життя: моло- дий вік та вік понад 55 років, низький рівень освіти та доходу, втрата сімейних стосунків, наявність психічних розладів, тривалість військового конфлікту. Серед людей, які пережили війну або інший конфлікт у попередні 10 років, кожна пʼята людина (22 %) страждатиме на депресію, тривожність, посттравматичний стресовий розлад, біполярний розлад або шизофренію. Низька якість життя у людей із посттравматичним стресовим розладом повʼязана із симптомами гіперзбудження. Вимушене переселення впливає на зниженням якості життя у більш пізньому віці та у віддаленому часі. Найнижчу якість життя зафіксовано у внутрішньо переміщених осіб. Як у демократичних, так і в недемократичних країнах іноземне військове втручання знижує фізичну якість життя до 20 % від того показника, який був до втручання. Висновки. Отримані результати вказують на необхід- ність постійної уваги суспільства не лише до потреб у сфері здоровʼязбереження, а й до добробуту, житла, зайнятості та загальної якості життя для підтримки фізичного, психічного та соціального здоровʼя як біженців, так і не біженців в короткостроковому і довгостроковому вимірах.
EFFECT OF RASKIN RICE INCOME AND PRICE ON RASKIN RICE CONSUMPTION LEVEL IN SIMPANG KIRI SUB-DISTRICT SUBULUSSALAM CITY
Authors: Syahlubis Endrian , Anwar Khairil
Published: May 2022

The purpose of this study is to see the influence of the income and the price of raskin rice to the level of consumption of the community of the Subulussalam. The data is obtainedfrom 100 respondents. The method of analysis used in research is quantitative research. The  result show thatthe price of raskin riceaffects the level of public consumption in Simpang Kiri district.
THE EFFECT OF THIRD PARTY FUNDS OF WADI`AH AND SAVING WIROAH GIRO ON PROFIT PT. SHARIA BRI BANK
Authors: Muzakir Muzakir , Dharma Yulius
Published: May 2022

This study aims to determine the effect of Third Party Funds Giro Wadi'ah and Wadi'ah Savings on PT. BRI Syariah Bank from 2008 to 2017. This study uses secondary data by processing data on a quarterly basis within a period of 10 years. From the results of the research partially, the Giro Wadi'ah variable has a partially significant influence on the dependent variable of net income and the Wadi'ah Savings variable has a partially significant influence on the dependent variable of net income. While the simultaneous test of Giro Wadi'ah and Tabungan Wadi'ah variables simultaneously or together has a significant effect on the dependent variable of net income at PT. BRI Syariah Bank.
THE EFFECT OF ISLAMIC HUMAN DEVELOPMENT INDEX ON POVERTY LEVEL IN BIREUEN DISTRICT PERIOD 2000-2017
Authors: Reza Muhammad , Juliansyah Hijri , Dharma Yulius
Published: May 2022

The study entitled "The Influence of the Islamic Human Development Index Against Poverty Levels in Bireuen District 2000-2017". The data used in this study are secondary data in the form of time series data from 2000-2017 obtained from BPS Bireuen. Data were analyzed by multiple regression methods. The results of the research based on Index ad-dien show that the crime rate has a significant negative effect on the poverty level, based on Index an-nafs shows that life expectancy does not have a significant effect on poverty levels, based on Index al-'aql shows that the average length of school has a negative effect significant to the level of poverty, Index an-nasl shows that the birth rate does not affect the level of poverty and expenditure per capita population does not affect the level of poverty in Bireuen District. This reflects that although per capita expenditure remains high, it will not increase the number of poor people in Bireuen District.