bluuebunny/crossref_metadata_2025 huggingface dataset:
Contradictory Conclusions on the Relationship Between CO2 Levels and Surface Temperature Anomalies
Authors: Takefuji Yoshiyasu
Published: February 2024

From an astronomical perspective, climate change has a significant impact on both life and the environment on Earth. This paper examines the statistical significance of the relationship between monthly global atmospheric CO2 levels and surface temperature anomalies using NOAA datasets. The p-value is used to determine the statistical significance of the data through linear regression. The analysis is based on trusted measures from March 1958 to June 2023, the period during which NOAA has been measuring global atmospheric CO2 levels at a single point and temperature anomalies with 2592 grid points of the global surface. The results reveal contradictory conclusions with high statistical significance, depending on the investigated period. These findings suggest that global CO2 levels alone may not be sufficient to predict global surface temperature anomalies.
Integration of transcriptomics, proteomics, phosphoproteomics analysis for characterization of pulmonary arterial hypertension in Chinese people
Authors: liu tianya , Zhou Siqi , Wang Rui , Xu Xiaomei , Gao Fang , Jie Zu , Wang Zhiping
Published: February 2024

Background
Pulmonary arterial hypertension (PAH), a fatal disease, is characterized by pulmonary vascular remodeling and vascular resistance. However, the molecular mechanisms underlying the pathogenesis of PAH remained to be incompletely understood.
Methods
RNA-seq, 4D Lable-free proteomics and phosphoproteomics were used to detect the levels of mRNA, proteins, and phosphoproteins in lung tissues from PAH patients, respectively. Parallel reaction monitoring (PRM) was carried out to verify the expression of the differentially expressed proteins.
Results
Totally, 967 differentially expressed genes (|log2FoldChange|>1 and p < 0.05), 764 differentially expressed proteins and 411 phosphoproteins were observed after data filtering (|log2FoldChange|>1 and p < 0.05) in lung tissues of PAH patients as compared with the control group. Integrated analysis of the three omic measures revealed that the biological processes involving inflammation, ion channel and metabolism were closely associated with PAH. Several signaling pathways, such as ferroptosis, HIF-1, PI3K-AKT, and Rap1 might be related to the development of PAH.
Conclusions
This study combined multi-omics characteristic profiling to find out the changed genes or proteins that contributed to a detailed pathogenic of PAH. It would have the benefit of looking for the novel and effective treatment targets and therapeutic drugs to PAH patients.
Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BKCa channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells
Authors: Pissas Karolos-Philippos , Gründer Stefan , Tian Yuemin
Published: February 2024

Fast growing solid tumors are frequently surrounded by an acidic microenvironment. Tumor cells employ a variety of mechanisms to survive and proliferate under these harsh conditions. In that regard, acid-sensitive membrane receptors constitute a particularly interesting target, since they can affect cellular functions through ion flow and second messenger cascades. Our knowledge of these processes remains sparse, however, especially regarding medulloblastoma, the most common pediatric CNS malignancy. In this study, using RT-qPCR, whole-cell patch clamp and Ca2+-imaging, we uncovered several ion channels and a G protein-coupled receptor, which were regulated directly or indirectly by low extracellular pH in DAOY and UW228 medulloblastoma cells. Acidification directly activated acid-sensing ion channel 1a (ASIC1a), the proton-activated Cl−channel (PAC, ASOR, or TMEM206), and the proton-activated G protein-coupled receptor OGR1. The resulting Ca2+signal secondarily activated the large conductance calcium-activated potassium channel (BKCa). Our analyses uncover a complex relationship of these transmembrane proteins in DAOY cells that resulted in cell volume changes and induced cell death under strongly acidic conditions. Collectively, our results suggest that these ion channels in concert with OGR1 may shape the growth and evolution of MB cells in their acidic microenvironment.
Different radius of curvature at the talus trochlea measured using 3D model technology
Authors: Wu Shixun , Liu Shizhang , Huang Minggang , Liu Zhe , Shi Jiyuan , Ling Ming
Published: February 2024

BackgroundTo analyze the curvature characteristics of thetalus trochlea inpeople from Northwest China in different sex and age groups.
MethodsComputed tomography scanning data of talus from 61 specimens were collected and constructed as a three-dimensional model by MIMICS software, anteromedial(AM), posteromedial(PM), anterolateral(AL), and posterolateral(PL) edge, anterior edge of medial trochlea, posterior edge of medial trochlea and anterior edge of lateral trochlea were defined according to the anatomical landmarks on trochlear surface. The curvature radii for different areas were measured using the fitting radius and measure module.
Results There were significant differences among the talus curvatures in the six areas (F=54.905, P=0.000), and more trends in the analytical results were as follows: PM > PL > MP > AL > MA > AM. The average posterolateral radius from specimens aged >38 years old was larger than that from specimens aged<=38 years (t=-2.303, P =0.038). The talus curvature of the AM for males was significantly larger than that for females (t=4.25, P=0.000), and the curvature of the AL for males was larger than that for females (t=2.629, P =0.010). For observers aged <=38 years, the AM curvature of the right talus in the male group was significantly larger than thatin the female group (P<0.01). In age <=38years group, the MA curvature of right talus in male was significantly larger than in female group(P<0.01), fitting radius of talus for male (21.90±1.97 mm) was significantly greater than female of this(19.57±1.26 mm)(t=6.894, P=000). The average radius of the talus in the male population was larger than that in the female population.
Conclusion There was no significant relationship between age and talus curvature in either males or females. The radius of curvature in the posterior area was significantly larger than that in the anterior area. We recommend that this characteristic of the talus trochlea should be considered when designingthe talus component in total ankle replacement (TAR).
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation
Authors: Mogensen Frida Lind-Holm , Sousa Carole , Ameli Corrado , Badanjak Katja , Muller Arnaud , Kaoma Tony , Coowar Djalil , Scafidi Andrea , Poovathingal Suresh K , Nicot Nathalie , Ginolhac Aurélien , Weisenhorn Daniela M Vogt , Wurst Wolfgang , Poli Aurélie , Nazarov Petr V , Skupin Alexander , Grünewald Anne , Michelucci Alessandro
Published: February 2024

Background
Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson’s disease (PD). However, the phenotypic acquisition of microglial cells and their role during the underlying neuroinflammatory processes remain largely elusive. Here, according to the multiple-hit hypothesis, which stipulates that PD etiology is determined by a combination of genetics and various environmental risk factors, we investigate microglial transcriptional programs and morphological adaptations under PARK7/DJ-1 deficiency, a genetic cause of PD, during lipopolysaccharide (LPS)-induced inflammation.
Methods
Using a combination of single-cell RNA-sequencing, bulk RNA-sequencing, multicolor flow cytometry and immunofluorescence analyses, we comprehensively compared microglial cell phenotypic characteristics in PARK7/DJ-1 knock-out (KO) with wildtype littermate mice following 6- or 24-hour intraperitoneal injection with LPS. For translational perspectives, we conducted corresponding analyses in human PARK7/DJ-1 mutant induced pluripotent stem cell (iPSC)-derived microglia and murine bone marrow-derived macrophages (BMDMs).
Results
By excluding the contribution of other immune brain resident and peripheral cells, we show that microglia acutely isolated from PARK7/DJ-1 KO mice display a distinct phenotype, specially related to type II interferon and DNA damage response signaling, when compared with wildtype microglia, in response to LPS. We also detected discrete signatures in human PARK7/DJ-1 mutant iPSC-derived microglia and BMDMs from PARK7/DJ-1 KO mice. These specific transcriptional signatures were reflected at the morphological level, with microglia in LPS-treated PARK7/DJ-1 KO mice showing a less amoeboid cell shape compared to wildtype mice, both at 6 and 24 hours after acute inflammation, as also observed in BMDMs.
Conclusions
Taken together, our results show that, under inflammatory conditions, PARK7/DJ-1 deficiency skews microglia towards a distinct phenotype characterized by downregulation of genes involved in type II interferon signaling and a less prominent amoeboid morphology compared to wildtype microglia. These findings suggest that the underlying oxidative stress associated with the lack of PARK7/DJ-1 affects microglia neuroinflammatory responses, which may play a causative role in PD onset and progression.
A New Lightweight Network for Real-time Detection of Railway Infrastructure
Authors: Cheng Yu , Cheng ruijun
Published: February 2024

The deployment of deep convolutional neural network in railway infrastructure real-time detection is largely hindered by huge computing costs. This paper proposes a new lightweight network called S-CA-YOLOv5, in which a new backbone combined ShuﬄeNet with Coordinate Attention is used to reduce the computational complexity, and the CA mechanism can capture regions of interest accurately. Moreover, the improved loss function with Eﬃcient Intersection over Union facilitates more accurate localization and classiﬁcation, which is conducive to higher detection precision and faster convergence speed. Finally, through channel pruning combined with knowledge distillation ﬁne-tuning, the model is further lightweight. Compared with other methods, our proposed method achieves the best trade-oﬀ between detection precision and speed. Hence, the proposed method has the potential to achieve real-time detection for the railway infrastructure based on embedded Graphic Processing Unit platforms.
SPHK1 promotes the migration and invasion of gastric cancer cells through NF-κB pathway
Authors: Ling Qianlong , Ji Kai , Guan Jiajia , Wang Ruipeng , Zhu Bing
Published: February 2024

Background: Gastric cancer (GC) is one of the most common malignant tumors. Sphingosine kinase-1 (SPHK1) is a member of the SPHK family of proteins,which are involved in the pathogenesis of various cancers. This study aimed to investigate SPHK1 expression in GC tissues, and its effects on the migration and invasion of GC cell lines.
Methods: Bioinformatics predicted SPHK1 expression and prognosis. The expression of SPHK1 was detected by immunohistochemistry. Real-time PCR analysis was used to detect SPHK1mRNA expression. Cell migration was detected by cell scratch methods. Cell migration and invasion were detected by Transwell assays. Western Blotting was used to detect protein expression.
Results: The expression of SPHK1 in GC was significantly higher than that in matched non-cancer tissues. Knockdown of SPHK1 can reduce the migration and invasion of GC cells, while overexpression of SPHK1 has the opposite effect. In addition, SPHK1 positively regulates protein levels of phosphorylated P65(p-P65), as well as protein expression of vascular endothelial growth factor A(VEGFA) and interleukin 17(IL-17) at transcriptional targets of the NF-κB signaling pathway. The blockage of the NF-κB signaling pathway by PDTC could reverse the SPHK1-promoted GC cell migration and invasion.
Conclusions: Our results elucidate the key role of SPHK1 in promoting GC cell migration and invasion, and suggest that SPHK1 may be a potential molecular target for preventing GC metastasis.
Preparation, Isolation and Structural Characterization of Transient Species of DBU. Their Application as Green Reagents
Authors: Thangalipalli Swathi , Bandalla Siddarama Goud , Vadala Jhansi Rani , Neella Chandra Kiran
Published: February 2024

A state of the art synthesis and isolation procedure is developed for 17 different transient species of DBU. The structure of these transient species, which are thoroughly confirmed from various spectral data, is different from their parent compound DBU and provides emphatic support in favor of formation of transient species in various DBU catalyzed reactions. DFT studies of N-sulphonylTransient species of DBU has given a new insight of an alternate transient species in addition to the normal species which provides a new scope for further investigation. The applications of three Transient species as direct reagents for base free functionalizations are also documented. They can be directly employed as Eco-friendly reagents in water as solvent. The Lewis base can be recovered and reused for the preparation of Transient species after the reaction. The influence of N-substituent on the chemical shift of these transient species also documented.
An optimization of traditional CPU emulation techniques for execution on a quantum computer
Authors: FITZJOHN JAMES , WILSON GEORGE , VICINANZA DOMENICO
Published: February 2024

The use and adoption of quantum computers by the wider computing community has been impeded by the need to adopt new programming techniques. These techniques involve moving from a high-level language where the programmer can define and manipulate objects, to a quantum model where the programmer defines and configures the circuits at a gate level. A jump too far for many. Previous work by the authors aimed to ease this transition through the use of a software development kit (Qx86 SDK) that emulates a traditional CPU for execution on a quantum computer which focused on delivering the capability. This paper now presents a number of new methods that extends and improves the SDKs capability. These methods include optimizing traditional logic gate emulation, multiple gate simplification methods, reducing the number of required qubits, and alternative optimized techniques for many CPU instructions. A quantum machine code mapping method is also described to propose the emulation of a traditional/quantum hybrid CPU prototype. Whilst still orders of magnitude slower than the performance of a traditional CPU in terms of arithmetic, logic and bitwise operations, execution speed is shown to be markedly improved (in some cases by more than 1,000%) and without introducing any unrealistic requirements (that is, all execution can be performed utilizing less than 32 qubits). The usefulness of the SDK has now been enhanced as a reference guide, where the programmer/researcher can contrast traditional methods vs multiple quantum methods of execution.
ENLUS: Bridging Language Divide with English-Mizo Machine Translation Corpus
Authors: Lalrempuii Candy , Soni Badal
Published: February 2024

In this work, we present ENLUS, a parallel and monolingual corpus of the English-Mizo language pair developed for machine translation. ENLUS monolingual corpora have been collated from publicly available news and media websites in Mizo. The parallel data has been collected from various online and offline sources. Machine translation has recently made significant progress in high-resource language scenarios. The quantity of linguistic data mostly determines how well the translation models work. In a multilingual culture like India, most languages are under-resourced with scant to no data. Therefore, there is an evident need for reliable, freely accessible resources to carry out the translation. Mizo is an Indian language that is under-explored due to limited resources. We outline the procedures used to create and validate both corpora. We train popular machine translation techniques, including unsupervised and supervised models, on this corpus. We also compare the translation results to those of Google Translate, which is a commercial translation service. For the purpose of comparing all the models, we use the publicly available evaluation benchmark, FLORES-200, which recently included the Mizo language. Our empirical findings reveal that the multilingual NMT system outperforms existing bilingual techniques and commercial translation tools.
Protective Factors for Suicidal Behaviour in Adults Self-reported as LGBTQ+: A Study Based on Modulating Variables
Authors: Sánchez-Teruel David , Singh Harpaljit Kaur Pritam , Sánchez-Barrera María Blasa , Bello María Auxiliadora Robles
Published: February 2024

Background
This study aims to identify factors that modulate resilience in LGBTQ + individuals with a history of suicide attempts and reattempts. The researchers hypothesize that positive mental health and various internal and external protective factors will predict suicide resilience in this population.
Method
112 LGBTQ + Spanish people (60.7% self-reported as female, 34.8% as male, and 4.5% did not identify their gender) aged 18–41 years with self-harm or previous suicide attempts completed several questionnaires measuring variables such as self-efficacy, emotion regulation, social support, entrapment, anxiety, depression, positive mental health, and resilience.
Results
Regarding the protective variables most predictive of resilience, it was found that social support, positive mental health, and emotional regulation were vital and to a lesser extent, self-efficacy expectations for coping with stressful or adverse situations. In addition, the path analyses revealed distinct profiles of modulated categorical variables in LGTBQ + individuals who had attempted suicide once or who had attempted suicide two or more times.
Conclusions
These findings highlight the importance of addressing protective factors, such as social support and positive mental health, in promoting resilience and reducing suicide risk among LGBTQ + individuals.
On Super-rigidity of Gromov's Random Monster Group
Authors: Das Kajal
Published: February 2024

In this article, we show super-rigidity of Gromov’s random monster group. It is known from a paper of Assaf Naor and Lior Silberman that any homomorphic image of Gromov’s random monster group into a linear group is finite. It can be also derived from the previously known results that the same result is true for a-Lp-menable groups and K-amenable groups. We extend these results and prove that any morphism ϕα from Gromov’s random monster group Γα to a countable discrete group G has finite image for almost all α, where G is any of the following types of groups: mapping class group MCG(Sg,b), braid group Bn, outer automorphism group of a free group Out(FN), automorphism group of a free group Aut(FN) and hierarchically hyperbolic group. For acylindrically hyperbolic groups, we deduce that the homomorphic image is absolutely elliptic. We introduce another property called hereditary super-rigidity. It immediately follows from the literature that Γα has hereditary super-rigidity with respect to an a-Lp-menable group or a K-amenable group for a.e. α. In this article, we establish a stability result for the groups with respect to which Γα has super-rigidity and hereditary super-rigidity.
Mathematics Subject Classification (2020): 20F65, 20F67, 20P05, 53C24, 57K20.
MolNexTR: A Generalized Deep Learning Modelfor Molecular Image Recognition
Authors: CHEN Yufan , LEUNG Ching Ting , HUANG Yong , SUN Jianwei , CHEN Hao , GAO Hanyu
Published: February 2024

In the field of chemical structure recognition, the task of converting molecular images into graph structures and SMILES string stands as a significant challenge, primarily due to the varied drawing styles and conventions prevalent in chemical literature. To bridge this gap, we proposed MolNexTR, a novel image-to-graph deep learning model that collaborates to fuse the strengths of ConvNext, a powerful Convolutional Neural Network variant, and Vision-TRansformer. This integration facilitates a more nuanced extraction of both local and global features from molecular images.MolNexTR can predict atoms and bonds simultaneously and understand their layout rules. It also excels at flexibly integrating symbolic chemistry principles to discern chirality and decipher abbreviated structures.We further incorporate a series of advanced algorithms, including improved data augmentation module, image contamination module, and a post-processing module to get the final SMILES output. These modules synergistically enhance the model's robustness against the diverse styles of molecular imagery found in real literature. In our test sets, MolNexTR has demonstrated superior performance, achieving an accuracy rate of 81-97%, marking a significant advancement in the domain of molecular structure recognition.
Roadmap towards gender equality: analyzing the influence of foreign direct investment on wage dynamics
Authors: Mutai Noah , Katusiime Juliet , Dervishaj Valdrin , Popoola Olufunke Mercy
Published: February 2024

This study investigates the relation between foreign direct investments (FDI) and wage dynamics in Germany, Austria, and the Netherlands, aiming to develop a sustainable roadmap for reducing gender inequalities. Selected for their diverse labor dynamics, sustainability commitments, and gender equality situations, these countries serve as ideal case studies. Data spanning 1991 to 2021 on FDI and the percentage of gender-based workers were collected from the World Bank Development Indicators. Employing various linear regression models, our research examines the relationship between current and lagged wages for different genders, shedding light on how FDIs may influence wage patterns, especially regarding gender inequality. The quantitative study affirms the model's robustness, revealing a clear linear association between FDIs and salaries in these nations. This underscores the potential impact of foreign investments on wage dynamics, providing a foundation for addressing and reducing gender inequalities.
JEL Classification: F23, J31, O15
New distributional record of two gobioid fishes (Actinopterygii: Gobiiformes) with record of one more gobioid genus from Chilika lagoon, India
Authors: Behera Rajesh Kumar , Mohanty Swarup Ranjan , Behera Bhaskar Chandra , Mishra Subhrendu Sekhar , Mohapatra Anil
Published: February 2024

Morphometrics and meristic study reveal the first ever record of the genus Gobiopsis and two gobioid species Gobiopsis macrostomus (Long-jaw goby) (Gobiidae) and Oxyurichthys papuensis (Frog-face goby) (Oxudercidae) from Chilika lagoon, Odisha, India. Present paper deals with the range extension of one genus and two gobioid fishes as additions to the ichthyofaunal diversity of Chilika lagoon, Odisha.
Exploring the Impact of Socio-Cultural Factors on Entrepreneurship Development in Emerging Markets
Authors: Gupta Reena
Published: February 2024

This qualitative inquiry delves into the multifaceted impact of socio-cultural factors on entrepreneurship development within emerging markets. Through thematic analysis of interview data from 30 participants, key insights emerged regarding the influence of cultural values, social networks, and institutional environments on entrepreneurial motivations, behaviors, and strategies. Cultural values, including collectivism, risk aversion, and attitudes towards failure, shape the context-specific manifestations of entrepreneurship, emphasizing the importance of culturally sensitive interventions. Social networks serve as critical conduits for resource mobilization, knowledge exchange, and market access, yet also present challenges related to trust, inclusion, and power dynamics. Institutional environments significantly impact entrepreneurship, highlighting the need for supportive reforms to unlock the entrepreneurial potential of emerging markets. Entrepreneurs demonstrate resilience and adaptability in navigating socio-cultural and institutional challenges, underscoring the importance of fostering a culture of innovation and continuous learning within entrepreneurial ecosystems. Moving forward, interdisciplinary research and collaborative efforts are needed to deepen our understanding of the complex interplay between socio-cultural factors and entrepreneurship dynamics in diverse cultural contexts. By leveraging cultural diversity, strengthening social capital, and promoting entrepreneurial resilience, stakeholders can harness the transformative power of entrepreneurship to drive inclusive development and positive change in emerging markets worldwide. This research provides a foundation for policymakers, practitioners, and scholars to design targeted interventions and support mechanisms that foster vibrant and resilient entrepreneurial ecosystems in emerging markets.
Challenges for COVID-19 surveillance through wastewater-based epidemiology in post-pandemic era: A retrospective study in 222 USA counties
Authors: Li Xuan , Li Jibin , Liu Huan , Mínguez-Alarcón Lidia , Gao Li , Loosdrecht Mark C. M. van , Wang Qilin
Published: February 2024

The post-pandemic world still faces ongoing COVID-19 infections, where wastewater-based epidemiology (WBE) is recognized as an efficient tool for the population-wide surveillance of COVID-19 infections. Utilizing weekly county-level wastewater-surveillance data during pandemic across 222 counties from 49 states in United States of America (USA) from June 2021-November 2022 and covering 104 M populations, we retrospectively evaluated the correlation between SARS-CoV-2 RNA concentrations in wastewater (CRNA) and reported cases as well as the impacts of demographics, socioeconomical, test accessibility, epidemiological, environmental factors and international air travelling on reported cases under the corresponding CRNA. The lift of travel restrictions in June 2022, a milestone for the post-pandemic era, shifted the correlation between CRNA and COVID-19 incidence in following 7-day and 14-day from 0.70 (IQR: 0.30-0.88) and 0.74 (IQR: 0.31-0.90) to 0.01 (IQR: -0.31-0.36) and -0.01 (IQR: -0.38-0.45), respectively. In post-pandemic period, under the same CRNA, the reported case numbers were impacted by international passengers, test accessibility, Omicron prevalence, ratio of population aged between 18-65, minority vulnerability, and healthcare system. These factors bring new challenges in post-pandemic era, which needs additional attention while using WBE surveillance for COVID-19 infections. This study facilitates public health authorities to dynamically adjust their WBE to the local context to achieve optimal community surveillance.
Give birth to a female child: A qualitative study exploring mothers' experiences of multiple female childbirths in Jordan
Authors: Eid haifa
Published: February 2024

Background: Childbirth experiences were distinctive, exceptional feelings, reactions to postpartum women. Major difficulty facing maternal, such as Gender is the main social determinants, female gender is socially and culturally shaped by the roles and responsibilities.
Aims: To clarify the experience of Jordanian mothers, who given birth to daughters ‘multiple female childbirth’. Also, to understand childbirth experiences and their meaning is important in projecting individualized care for mothers. Also, to investigate meaningful childbirth experiences among postpartum mothers.
Methodology: Phenomenology approach design. The target population for this study is Jordanian mothers who have multiple female childbirth. A convenience purposive method was selected to recruit participants who met the criteria. The sample size will be between 10-12 participants and the researcher stopped collecting data and conducting interviews when no new themes or data emerged following data analysis, Data analysis using Colaizzi’s (1978) method.
Results: According to analysis of one story describing postpartum mother the result demonstrated that are two themes. The first theme: Challenges faced by woman regarding psych-emotional health, and the second theme: lack of family and spousal coping methods that described the essence of mother experience for multiple female childbirth. The findings from the interview have emerged, as themes broken into sub-themes and codes.
PERITONEAL TUBERCULOSIS MIMIKING GASTROINTESTINAL STROMAL TUMOR
Authors:   Department of Surgery, Fourth Military Hospital Dakhla, Morocco., Belhamidi M.S , Slioui B. ,   Department of Radiology, Fourth Military Hospital Dakhla, Morocco., Bensal A. ,   Department of Surgery, Fourth Military Hospital Dakhla, Morocco.
Published: February 2024

Abdominal TB is a common site of extrapulmonary tubercilosis, and peritoneal tuberculosis (PTB) is one of the most common manifestations of abdominal tuberculosis. The diagnosis of PTB can be made based on a combination of clinical, radiological, histological, and laboratory tests. The diagnosis can be easy in the presence of ascites with peritoneal granulations. some forms of PTB can make a differential diagnosis with peritoneal or digestive tract pathologies. some forms of PTB can make a differential diagnosis with peritoneal or digestive tract pathologies. We report a case of primary mesenteric tuberculosis mimicking gastrointestinal stromal tumor. The final diagnostic was performed using a combination of invasive and imaging techniques.
STUDY OF PERMANENT MAGNET SYNCHRONOUS MOTOR DEMAGNETIZATION FAULT DETECTION USING SIGNAL ANALYSIS TECHNIQUES
Authors:   Researcher, Automotive Eng. Department, Faculty OF Engineering, Helwan University, Egypt., A.E. Badawy Mohamed , A.A. Saad Ahmed ,   Professor of Automotive Eng. Department, Faculty of Engineering, Helwan University, Egypt., M.A. Mohamed Mostafa ,   Lecturer of Automotive Eng. Department, Faculty OF Engineering, Helwan University, Egypt.
Published: February 2024

Due to its obvious advantages, there is no doubt that Electric vehicles are gaining huge popularity. Thats due to the advantages of electric vehicles when compared to the traditional ICE vehicles. On the other hand, and as electric vehicles are still machines built by human beings, the EVs have several components that can be faulty and affect the vehicle performance and maybe in some stages lead to severe failures or life threatening. These components are mainly the battery, electric motor and controllers. So, many studies focused on studying the electric vehicles components fault detection in the early stages. In this paper, we will focus on one of the most common motor types, the permanent magnet synchronous motors. One of the common PMSM faults related to the rotor is the demagnetization. This fault will be extensively studied using two of the signal analysis method techniques: the output torque and the stator current signal analysis. Using the MATLAB SimuLink, a complete model of the PMSM will be built and the uniform demagnetization fault will be introduced. Then, a comparison between both torque and current signatures will be presented to put our hands on the ability of these techniques to identify the uniform demagnetization fault.
OBSERVATIONAL STUDY ON SILENT CEREBRAL INFARCT IN CHILDREN OF SICKLE CELL DISEASE IN ASSOCIATION WITH RISK FACTORS
Authors: Sri Padma Priya Pallavi (MBBS) Bonthu , Tejaswi (MBBS) Karrothu , Deve Varma Bsk (MBBS , MD Pediatrics) Chandra , Lokeswara Reddy (MBBS , MD Pediatrics) Vundela , Saikiran (MBBS) Metta
Published: February 2024

Aim and Objectives: To find out the presence of silent cerebral infracts (SCI) among sickle cell diseased children and to identify risk factors and correlate risk factors with silent cerebral infracts in sickle cell diseased children.. Settings, Design. Methods and Materials: The children who came to paediatrics department of maharaja institute of medical sciences, with confirmed haemoglobin electrophoresis findings of sickle cell disease in steady-state are subjected to T2 weighted MRI scan of the brain using Philips ingenia CX 1.5Tesla MRI machine. Results: out of 50 children with sickle cell disease ,18(36%) children have silent cerebral infarct and it was observed that the lower hemoglobin concentration, Lower RBC count, Lower Serum Ferritin, and elevated WBC count were considered to be the potential risk factors for Silent cerebral infarcts in Sickle cell disease. Conclusion : Patients with risk factors for silent cerebral infarcts should be evaluated for cerebrovascular disease. If evidence of the presence of SCI, consideration must be given to therapeutic intervention.
AWARENESS AMONG MOTHERS REGARDING CARE OF CHILD DURING PRIMARY IMMUNIZATION - AN INTERVENTIONAL STUDYIN SELECTED HEALTH FACILITY OF HIMACHAL PRADESH
Authors:   PhD Scholar, Child Health Nursing, Swami Rama Himalayan University, Uttarakhand., Sharma Neeti , Pugazhendi Sanchita ,   Professor, Community Health Nursing, Department of Nursing, Swami Rama Himalayan University, Uttarakhand., Semwal Jayanti ,   Professor, Department of Community Medicine, Swami Rama Himalayan University, Uttarakhand.
Published: February 2024

Background: Immunization is an important event in a childs life. Awareness of mothers regarding immunization is an important factor affecting adherence to immunization. Materials and Methods: The study was conducted in Zonal hospital, Solan (HP) to determine effectiveness of an interventional package in terms of awareness of mothers regarding care of children during primary immunizations. Apre-test post-test control group design was used to achieve the objective. Seventy five mothers were enrolled in interventional and control group using systematic random sampling and followed on every immunization event until nine months. Awareness among mothers was assessed at immunization events namely birth, six weeks and nine months using a self-structured tool to assess vaccine related problems among children. Results: Significant increase in the awareness level was seen among mothers in the interventional group and was found associated with their number of children. Conclusion: The interventional package significantly increased awareness among mothers in the intervention group in the initial weeks.
BRIDGING THE GAP: UNDERSTANDING MEDICAL STUDENTS' AND INTERNS'PERCEPTIONS OF RADIOLOGY AS A CAREER CHOICE AT TAIF UNIVERSITY, SAUDI ARABIA
Authors:   Associate Professor of Radiology, Internal Medicine Department, Faculty of Medicine, Taif University, Saudi Arabia., Al Zahrani Yahea
Published: February 2024

Background: Radiology is a fundamental pillar of modern medicine, providing essential diagnostic and treatment guidance. Despite its importance, radiology faces challenges in attracting medical students as a career option. Objective: To identify factors influencing medical students' and interns' perceptions of radiology as a specialty. Methods: A cross-sectional study was conducted among Taif University medical 6th-year medical students and interns using a self-administered questionnaire including items to explore participants' knowledge, perceptions, and interest in radiology as a potential career path. Results: The study included 216 students and interns with a response rate of 91.9%. Males constituted 79.2% of them. Only a minority (18.5%) considered radiology as their future career aspiration. Exposure to radiology lectures during medical school was the most appealing factor (37%). Significant deterrents included concerns about losing clinical skills (45.8%), occupational hazards (41.2%), lack of recognition (40.7%), and limited patient contact (39.8%). The absence of patient interactions was the primary reason for disinterest in radiology (29.2%).Males were more likely than female students to choose radiology as a future career (20.5% vs. 11.1%), p<0.001. Also, participants with a higher level of knowledge about the radiology specialty were more likely than those with limited or no knowledge about it (33.3% vs. 25.2 and 7.7%, respectively), p=0.002. Conclusion:More than half of the medical students and interns surveyed expressed doubts about pursuing radiology. Male participants were more likely than female participants to be interested in radiology.To address this, introducing early and comprehensive diagnostic imaging education throughout the undergraduate years and incorporating theoretical and practical approaches could attract more medical students and interns to the field of radiology.
MECHANISMS AND LEGAL RESPONSIBILITIES OF NURSES IN CARRYING OUT EMERGENCY MEASURES IN THE INTENSIVE CARE UNIT
Authors:   Law Firm JOHN & Partners, Indonesia., Ojak Haholongan Nadeak Jasmen
Published: February 2024

In carrying out their duties and authority in treating patients in the Intensive Care Unit (ICU), a nurse is required to obtain a mandate from a doctor, which is a legal relationship that arises as a result of delegation of authority. This certainly has a clear mechanism because it will have legal consequences if errors or omissions occur in the delegation of authority. In fact, there are still cases that have fatal consequences for patients and those who are asked to be held accountable are nurses whose capacity is only as recipients of mandates. The method in this research is empirical juridical and normative juridical, based on field data and statutory regulations and related documents. The results of this research show that doctors who are unable to carry out medical procedures due to certain factors may ask the nurse for help to carry out medical procedures, provided that the doctor is obliged to provide a clear delegation of authority to the nurse in writing to carry out the medical procedure. Delegation of authority to carry out medical procedures from doctors to nurses as intended in Article 27 letter a Minister of Health Regulation Number 26 of 2019 concerning Explanation of Law No. 38 of 2014 concerning Nursing can take the form of delegation of delegated authority or mandate. Delegation of authority to carry out medical procedures must be done in writing to professional nurses or trained vocational nurses. Emergency actions carried out by nurses aim to save the patients life and prevent further disability. The delegation of authority is mandatorily given by doctors to nurses to carry out medical procedures under the supervision of the medical personnel who delegate authority. The form of accountability can be in the form of civil law, criminal law and administrative law, so that all three can provide their own sanctions for violations that occur due to losses, negligence or administrative errors.
MULI BEKIPAS DANCE FORM AT KUSUMA LALITA STUDIO, METRO CITY
Authors:   Student, Dance Eduaction Program, University of Lampung, Indonesia., Apriliani Helda , Habsary Dwiyana ,   Assistant Professor, Dance Education Program (In Dance Major), University of Lampung, Indonesia., Kurnia Adzan Nabilla ,   Lecture, Dance Education Program (In Dance Major), University of Lampung, Indonesia.
Published: February 2024

This research discusses the study of the Muli Bekipas dance choreography at the Kusuma Lalita studio in Metro City. This research aims to describe the study of choreography in the Muli Bekipas dance which includes movements, floor patterns, make-up, clothing, dance props and musical accompaniment. The research design is a qualitative method with data collection techniques in the form of observation, interviews and documentation. The theory used in this research is Sumandiyo Hadis choreographic study concept which describes or records dance by analyzing dance phenomena that are visible from the external form only, which can be done by studying the form, technique and style of movement. The study of the forms presented in the Muli Bekipas dance has dance forms that are categorized as quite complex dances. The results of the research show that the Muli Bekipas dance has twenty-eight movement sequences created from the development of Lampung dance movements, namely the Sigeh Penguten dance, Melinting dance and Bedana dance. Apart from that, the Muli Bekipas dance also has clothing that is typical of Lampung. This dance is accompanied by music with five beats and the lyrics of the Lampung song which describes the Muli Bekipas dance.
ACUTE LIVER FAILURE ASSOCIATED WITH COVID-19 IN A 2-YEAR-OLD BOY
Authors:   Pediatric Resident Abha Maternity and Child Hospital., M. Alhunif M.D Bayan , M.D Alasmari ,   Consultation Pedatric Cardiology Abha maternity and Child Hospital., F. Abbag M.D Huda ,   Pediatric Specialist Abha Maternity and Child Hospital.
Published: February 2024

Almost 2 years after the first cases of the SARS-CoV-2 pandemic were reported, we are still learning about it till today. We are now more familiar with SARS-CoV-2 and its role in causing COVID-19 and that the effects of the disease is mostly a respiratory illness (1).The gastro-intestinal/hepatic systems are the next most commonly affected after the respiratory system (2). Symptoms typically include nausea, vomiting, diarrhoea and abnormal liver enzymes (2). Acute liver failure secondary to covid-19 is rare and usually occurs later in the course of the disease (2). Some studies have demonstrated that SARS-CoV or MERS caused liver injuries with elevated liver enzymes and bilirubin levels, although these changes were mild (4). Studies of COVID-19 infection have shown the incidence of liver injury to be between 14.8 to 53%, mainly presentingwith abnormal alanine transaminase/aspartate aminotransferase (ALT/AST)(4).However alkaline phosphatase remains in the normal range in both mild and severe cases. Liver injury is significantly higher in patients with severe COVID-19.The effects of COVID-19 and it sequelae in children is still not widely reported. We describe a unique case of acute liver failure in a 2 year old boy most likely due to COVID-19in Saudi Arabia.
AYURVEDIC MANAGEMENT OF BRACHIAL PLEXOPATHY: A CASE REPORT
Authors:   Assistant Professor, Department of Kayachikitsa, Government Ayurveda Medical College and Hospital, Mysuru., Guled Siddaram , Iqra Sumayya ,   Second Year Postgraduate, Department of Kayachikitsa, Government Ayurveda Medical College and Hospital, Mysuru.
Published: February 2024

Background:The Brachial Plexopathy is a condition characterized by a lesion of the brachial nerve plexus. Depending on the aetiology, brachial plexopathy is classified as post-traumatic, infectious, toxic, compressiom-ischaemic, dysmetabolic and auto-immune. Among the causative factors, injuries are the most common. Symptoms include numbness, paraesthesia, weaknessin shoulder, arm and hand. Based on the references in Ayurvedic literature it can be correlated to Apabahuka. Case Presentation:A 51-year-old male patient with the diagnosis of brachial plexopathy reported to OPD with complaints of weakness of right upper limb for 8 months associated with stiffness of right shoulder joint. The patient was treated with Ayurvedic therapeutic interventions such as nasya karma, greeva basti, Sthanika seka, sarvanga abhyanga and sarvanga shashtika shaali pindasweda, sthanika upanaha swedaalong with Vatakaphahara and Vataharashamanoushadhiswere prescribed. Conclusion: After 15 days of treatment, there was marked relief in the symptoms in the form of reduced weakness and stiffness of right upper limb. The above treatment protocol along with oral medications has shown significant result clinically in the present study.
DIFFICULTIES IN RESEARCH PROPOSAL WRITING
Authors: Alasmari Faris , Alomary Saleh , Aljarallah Mohammed , Omair Aamir , Mohamud Mohamud , Masuadi Emad
Published: February 2024

Background: Medical students face difficulties during research proposal development. This study aimed to identify proposal writing difficulties among medical students to provide better targeted research education. Methods: A cross-sectional study conducted in King Saud Bin Abdulaziz University for Health Science using a self-administered questionnaire, which included 21 items assessing the difficulty of proposal segments. A content validity was done and piloted. Cronbachs alpha and exploratory factor analysis were used to assess the reliability and construct validity of the questionnaire. Results: Two-hundred seventy-six participants responded with a response rate of 55%, 196 of which were males. The most common difficulty was in the statistical analysis section (70%) followed by finding full text articles (49%) then determining sample size (46%). The least common were writing ethical consideration (14%), objectives (17%) and describing study subjects (19%). Difficulty mean was significantly lower among students who have completed their research projects compared to those who have not (mean + SD) 2.91+0.45 vs 3.2 +0.43 with a p-value of < 0.001, respectively. GPA nor gender had an effect on the level of difficulty. Conclusion: Students face difficulties in proposal writing particularly sections related to analysis plan and finding related articles. Further research is needed to support and improve studentsability to write good research proposals.
Neuro quantum-inspired decision-making for investor perception in green and conventional bond investments
Authors: Birzhanova Aigerim , Nurgaliyeva Aliya , Nurmagambetova Azhar , Dinçer Hasan , Yüksel Serhat
Published: February 2024

The purpose of this study is to make a comprehensive analysis of investor perceptions in the context of green and conventional bond investments. For this purpose, a new model is presented by considering two steps. First, a criteria set is generated by considering balanced scorecard perspectives that are finance, customer, organizational effectiveness and learning and growth. After that, the neuro Quantum fuzzy M-SWARA method is considered to weight these criteria. Secondly, seven critical determinants for bond investments are identified that are coupon rates, volume, maturity, riskiness, liquidity, volatility, and tax considerations. Neuro Quantum fuzzy TOPSIS approach is employed to rank these factors. The main contribution of the study is that by combining the balanced scorecard framework and quantum-inspired decision-making techniques, this paper offers a novel and sophisticated decision-making model to understanding investor behavior. Similarly, in the proposed model, a new methodology is generated by the name of M-SWARA. In this framework, some enhancements are adopted to the SWARA technique. The weighting results indicate that meeting customer expectations is the most critical factor that affects the investor perception to make investments to the bonds. Moreover, according to the ranking results, it is concluded that coupon rates are the most important item for both conventional and green bond investors. On the other hand, with respect to the conventional bond investor, tax is the second most essential factor. However, regarding the green bond investors, volatility plays a critical role.
AcknowledgmentThis research has been/was/is funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (№ AP 19679105 “Transformation of ESG financial instruments in the context of the development of the green economy of the Republic of Kazakhstan”).