bluuebunny/crossref_metadata_2025 huggingface dataset:
The association of telomere length with substance use disorders: systematic review and meta-analysis protocol
Authors: Navarro-Mateu Fernando , Rubio-Aparicio María , Cayuela Pedro , Álvarez Francisco-Javier , Roca-Vega Agustín , Chirlaque María Dolores , Cayuela María Luisa , Husky Mathilde , Martínez Salvador , Sánchez-Meca Julio
Published: December 2019

Background

The present protocol was designed for a systematic review and meta-analysis aimed at determining the association of telomere length with substance use disorders with the exclusion of nicotine addiction, and to identify potential moderators of the effect of telomere length. Such methodological information may provide guidance to improve the quality of future research on this important topic.

Methods

Potential studies will be identified through electronic databases (PubMed/MEDLINE, EMBASE, PsycINFO, and Web of Science) up from inception onwards. The inclusion criteria will include published or unpublished observational studies (cohort, case–control, and cross-sectional studies) reporting telomere length in adult patients with substance use disorder compared with a control group. Non-human studies or other study designs such as reviews, case-only, family-based, and/or population studies with only healthy participants will be excluded, as well as those focused solely on nicotine addiction. The main outcome will be telomere length in adults with substance use disorder (primary) and, specifically, in those with alcohol use disorder (secondary). Two investigators will independently evaluate the preselected studies for possible inclusion and will extract data following a standardized protocol. Disagreements will be resolved by consensus. The risk of bias of all included studies will be assessed using the Newcastle–Ottawa Quality Assessment Scale for non-randomized studies. Data will be converted into standardized mean differences as effect size index, and random-effects models will be used for the meta-analysis. Cochran’s Q statistic, I2 index, and visual inspection of the forest plot will be used to verify study heterogeneity. Subgroup analyses and meta-regressions will be conducted to ascertain heterogeneity. Several sensitivity analyses will be conducted to address the influence of potential confounding factors. Publication bias will be examined using the “funnel plot” method with Duval and Tweedie’s trim-and-fill method and Egger test.

Discussion

This systematic review will assess the association of telomere length with substance use disorders aside from nicotine addiction.

Systematic review registration

PROSPERO registration number CRD42019119785
Analysis of apoptosis related genes in nurses exposed to anti-neoplastic drugs
Authors: Ramazani Maral , Jaktaji Razieh Pourahmad , Shirazi Farshad H. , Tavakoli-Ardakani Maria , Salimi Ahmad , Pourahmad Jalal
Published: December 2019

Background

Anti-neoplastic agents are widely used in the treatment of cancer and some non-neoplastic diseases. These drugs have been proved to be carcinogens, teratogens, and mutagens. Concern exists regarding the possible dangers of the staff handling anti-cancer drugs. The long-term exposure of nurses to anti-neoplastic drugs is still a controversial issue. The purpose of this study was to monitor cellular toxicity parameters and gene expression in nurses who work in chemotherapy wards and compare them to nurses who work in other wards.

Methods

To analyze the apoptosis-related genes overexpression and cytotoxicity effects, peripheral blood lymphocytes obtained from oncology nurses and the control group.

The results

Significant alterations in four analyzed apoptosis-related genes were observed in oncology nurses. In most individual samples being excavated, Bcl-2 overexpression is superior to that of Bax. Prominent P53 and Hif-1α up-regulation were observed in oncology nurses. Moreover, all cytotoxicity parameters (cell viability, ROS formation, MMP collapse, Lysosomal membrane damage, Lipid peroxidation, Caspase 3 activity and Apoptosis phenotype) in exposed oncology nurses were significantly (p < 0.001) higher than those of unexposed control nurses. Up-regulation of three analyzed apoptosis-related genes were observed in nurses occupationally exposed to anti-cancer drugs.

Conclusion

Our data show that oxidative stress and mitochondrial toxicity induced by anti-neoplastic drugs lead to overexpression of apoptosis-related genes in oncology nurses.
Temporal changes in the distinct scattered wave packets associated with earthquake swarm activity beneath the Moriyoshi-zan volcano, northeastern Japan
Authors: Amezawa Yuta , Kosuga Masahiro , Maeda Takuto
Published: December 2019

We investigated temporal changes in the waveforms of S-coda from triggered earthquakes around the Moriyoshi-zan volcano in northeastern Japan. Seismicity in the area has drastically increased after the 2011 off the Pacific coast of Tohoku earthquake, forming the largest cluster to the north of the volcano. We analyzed distinct scattered wave packets (DSW) that are S-to-S scattered waves from the mid-crust and appeared predominantly at the high frequency range. We first investigated the variation of DSW for event groups with short inter-event distances and high cross-correlation coefficients (CC) in the time window of direct waves. Despite the above restriction, DSW showed temporal changes in their amplitudes and shapes. The change occurred gradually in some cases, but temporal trends were much more complicated in many cases. We also found that the shape of DSW changed in a very short period of time, for example, within ~ 12 h. Next, we estimated the location of the origin of the DSW (DSW origin) by applying the semblance analysis to the data of the temporary small-aperture array deployed to the north of the largest cluster of triggered events. The DSW origin is located between the largest cluster within which hypocentral migration had occurred and the low-velocity zone depicted by a tomographic study. This spatial distribution implies that the DSW origin was composed of geofluid-accumulated midway in the upward fluid movement from the low-velocity zone to the earthquake cluster. Though we could not entirely exclude the possibility of the effect of the event location and focal mechanisms, the temporal changes in DSW waveforms possibly reflect the temporal changes in scattering properties in and/or near the origin. The quick change in DSW waveforms implies that fast movement of geofluid can occur at the depth of the mid-crust.
Analysis of whole genome-wide microRNA transcriptome profiling in invasive pituitary adenomas and non-invasive pituitary adenomas
Authors: Zhang Chao , Qian Yuan , Qiao Yisheng , Li Yao , Wang Wei , Li Junjun , Deng Xingli
Published: December 2019

Background

Dysregulation of microRNAs (miRNAs) plays a critical role during the occurrence and progress of pituitary adenomas (PAs). However, the roles of miRNAs in the invasiveness of PA are poorly understood. This study aims to more comprehensively and specific define the relationship between altered miRNA and PA invasion.

Methods

The differential expression of miRNAs (DEMs) between invasive PAs (IPAs) and non-invasive PAs (NPAs) was explored by RNA sequencing and which functions were analyzed by gene ontology (GO) as well as Kyoto Encyclopedia of Genes and Genomes (KEGG). The miRNA-mRNA network was predicted with bioinformatics.

Results

We identified 31 upregulated miRNAs and 24 downregulated miRNAs in IPAs compared with NPAs. GO analysis and KEGG pathway analysis showed the DEMs were mainly associated with cell proliferation and cell cycle pathway. In addition, on the count of predicted miRNA-mRNA network, two hub miRNAs were identified.

Conclusions

Our results demonstrate the miRNA-mRNA network in detail, which suggest that miRNA may be a promising target in diagnosis and therapy for IPAs.
Direct prediction of petrophysical and petroelastic reservoir properties from seismic and well-log data using nonlinear machine learning algorithms
Authors: Priezzhev I. I. , Veeken P. C. H. , Egorov S. V. , Strecker U.
Published: December 2019

An analytical comparison of seismic inversion with several multivariate predictive techniques is made. Statistical data reduction techniques are examined that incorporate various machine learning algorithms, such as linear regression, alternating conditional expectation regression, random forest, and neural network. Seismic and well-log data are combined to estimate petrophysical or petroelastic properties, like bulk density. Currently, spatial distribution and estimation of reservoir properties is leveraged by inverting 3D seismic data calibrated to elastic properties (VP, VS, and bulk density) obtained from well-log data. Most commercial seismic inversions are based on linear convolution, i.e., one-dimensional models that involve a simplified plane-parallel medium. However, in cases that are geophysically more complex, such as fractured and/or fluid-rich layers, the conventional straightforward prediction relationship breaks down. This is because linear convolution operators no longer adequately describe seismic wavefield propagation due to nonlinear energy absorption. Such nonlinearity is also suggested by the seismic nonstationarity phenomenon, expressed by vertical and horizontal changes in the shape of the seismic wavelet (amplitude and frequency variations). The nonlinear predictive operator, extracted by machine learning algorithms, makes it possible in certain cases to estimate petrophysical reservoir properties more accurately and with less influence of interpretational bias.
Reviews
Authors: Macgregor Lucy , Bartel David , Jack Ian
Published: December 2019

Introduction to Controlled-Source Electromagnetic Methods, by Anton Ziolkowski and Evert Slob, ISBN 978-1-107-05862-0, 2019, Cambridge University Press, 332 p. Seismic Ambient Noise, by Nori Nakata, Lucia Gualtieri, and Andreas Fichtner, ISBN 978-1-108-41708-2, 2019, Cambridge University Press, 370 p.
The Researcher as a National Security Threat
Authors: Bajoghli Narges
Published: December 2019

Based on ethnographic research in Iran among the country's Islamic Revolutionary Guards Corps (IRGC) and its Basij militia, this article explores the process of gaining access to these militarized groups in order to conduct long-term research. Specifically, what does it mean to build rapport and gain trust within a highly securitized space such as this? What happens when the researcher is a potential “national security” threat in both Iran and the United States? How is national security enacted in everyday interactions in the field? Given that anthropologists have tended to have an affinity with the group and community they work with, this article explores the implications of research among a group of men in charge of surveillance, intelligence gathering, and citizen suppression in the country. The article argues that in the midst of national security rhetoric, interrogative surveillance is a strategic tool that makes space for engagement.
Correspondence, Constructivism, and Representation
Authors: Quadri Junaid
Published: December 2019

Taking the complexity and diversity of Islamic law (fiqh) as a point of departure, this article examines a series of positions advanced by Muslim jurists on the relationship between law and astronomy. Focusing primarily on the question of the appropriateness of relying on astronomical calculations to determine the months of the hijri calendar, it considers three epistemological stances modeled by these positions: correspondence, constructivism, and representation. Taken together, these interventions constitute a minoritarian strain within the fiqh literature that exploited the practices, structures, and methods of reasoning of the Hanafi and Shafi‘i legal schools (madhhabs) to argue in favor of the employment of astronomical calculations for ritual purposes. Though these were anomalous positions at variance from the dominant evidentiary regime that privileged perception over calculation, the view from the margins they afford provide a helpful window onto the nature of legal reasoning in Sunni Islam, revealing the importance of not only proximate social triggers to change, but also the relevance of more enduring features of madhhab reasoning—the school's role as a historical repository of jurists' opinions, the propensity to recruit the authority and argumentation of preceding departures, and the expectation to proceed with the majority regime in mind.
The Criminal and the Corrupt
Authors: Pierce Steven
Published: December 2019

The commentaries in this Kitabkhana on Milan Vaishnav's When Crime Pays and Steven Pierce's Moral Economies of Corruption provide ample food for thought about the social-scientific study of crime and corruption. All agree on the importance of focusing on actual practice and not forcing non-Western societies into Eurocentric heuristics. They also pose urgent questions about what might constitute grounded theories of governance and productive avenues for pushing for reform and change.
Max Weber: the invariance of domination
Authors: Ожиганов Эдвард , Ozhiganov Edvard
Published: December 2019

The monograph highlights max Weber's concept of domination, which is the counterpoint and organizing beginning of his interpretive sociology. The action of the law of invariance of domination in various areas of economic and political life is shown. The article presents a comparative analysis of Weber's views on the structure and dynamics of domination with the ideas of his contemporaries Thorstein Veblen and Robert Michels in the field of Economics and politics, which do not lose relevance in the modern world. Special attention is paid to Weber's concept of domination in the context of the transformation of democracy and capitalism.
For students and teachers, as well as all those interested in the problems of sociology of politics.
THE MAIN FACTORS OF IONIZING RADIATION OF OUTER SPACE ACTING ON MICROCIRCUITS
Authors: Журавлева Ирина , ZHuravlyeva Irina
Published: December 2019

In space, ionizing radiation is created by several sources. The most important generalized concepts about the degree of the Influence of space plasma is manifested through the electrification of dielectric protective and thermally insulating coatings inside the structure of electronic equipment. The article discusses the main effects of ionizing radiation on the semiconductor components of space communication systems.
MODELS OF AGRICULTURAL PRODUCTION OPTIMIZATION WITH EXPERT ESTIMATES OF SOWING TIMELINESS
Authors: Асалханов Петр , Asalhanov Petr , Иваньо Ярослав , Ivano Yaroslav , Полковская Марина , Polkovskaya Marina
Published: December 2019

The article proposes a parametric model of optimization of agricultural production using expert estimates characterizing the timeliness of sowing. It is proposed to use estimates obtained by one or a group of experts, which are agronomists, as coefficients of the influence of sowing dates on production parameters. The coefficients for the unknowns in the left-hand parts of the restrictions are described using trends and factor models based on time. One of the variants of the proposed problem of parametric programming was implemented for the CJSC «Irkutsk Seeds» of the Irkutsk District of the Irkutsk Region. The simulation results are given taking into account the expert estimates for two cases: timely and early (or late) sowing.
Product safety
Authors: Берновский Юрий , Bernovskiy Yuriy
Published: December 2019

The training manual contains a brief summary of the legislative framework for product safety. The role of technical regulations, national standards as a regulatory framework for product safety and environmental requirements is shown. Separate chapters are devoted to the safety of machinery and equipment, chemical, light, food and other products. At the same time, the fundamental technical regulations containing General requirements for the safety of product classes and national standards, the application of which ensures the implementation of product safety requirements, are considered.
Meets the requirements of the Federal state educational standards of higher education of the last generation.
It is intended for undergraduate and graduate students, as well as for specialists of enterprises and organizations engaged in the development of standards and specifications that establish requirements for the quality and safety of products.
Lean Six Sigma Approach to Improve the Production Process in the Mould Industry: a Case Study
Authors: Pereira António M.H. , Silva Miguel R. , Domingues Mercedes A.G. , Sá José C.
Published: December 2019

Purpose: The purpose of this article is to explore the optimization of internal process is assumed as a critical factor to be capable of answering to the moulds industries. Consequently, it has been considered essential to adopt high-valued methodologies to support tooling industry in order to achieve global competitive advantages. For that purpose, this work aims to apply LEAN principles and techniques to support mould design and manufacturing processes.Methodology/Approach: The methodology used was based on PDCA/DMAIC, with the following stages: Define, Measure, Analyze, Improve and Control. For each stages was taken some of Lean Six Sigma techniques, such as Continuous Improvement, Value Stream Mapping, Pareto analysis and Overall Equipment Effectiveness.Findings: This study results was revealed that there are many areas on the organizations in the Mould Industry, when they utilize otimizations tools obtain hugt successes. With the Pareto analysis was carried out to show that events that contributes the most to the stops. The results were: unavailability of the operator (16.4%), programming the machine (14.4%) and tool exchange (12.4%) In the case of this Mould Industry study was obtained for the CNC machines studies, with the implementation of Lean Six Sigma tools as obtained a improvement about 20% of global OEE.Research Limitation/implication: This research was revealed that there the moulds are Project unique and difficult to analyze. Moreover, this paper reports that the approach LEAN Six Sigma is very interesting for the continuous improvement of processes and profitability of moulds industry.Originality/Value of paper: This research highlight areas of future research using of quality management methods and Lean Six Sigma tools to analyse and optimize production in the moulds industry. Therefore this research It is considered to promote and adopt high-valued methodologies to support tooling industry in order to achieve global competitive advantages.
Primary reverse shoulder arthroplasty in patients older than 80 years of age
Authors: Clark Nicholas J. , Samuelsen Brian T. , Alentorn-Geli Eduard , Assenmacher Andrew T. , Cofield Robert H. , Sperling John W. , Sánchez-Sotelo Joaquín
Published: December 2019

Aims

Reverse shoulder arthroplasty (RSA) reliably improves shoulder pain and function for a variety of indications. However, the safety and efficacy of RSA in elderly patients is largely unknown. The purpose of this study was to report the mortality, morbidity, complications, reoperations, and outcomes of primary RSA in patients aged > 80 years.

Patients and Methods

Between 2004 and 2013, 242 consecutive primary RSAs were performed in patients aged > 80 years (mean 83.3 years (sd 3.1)). Of these, 53 were lost to follow-up before two years and ten had died within two years of surgery, leaving 179 for analysis of survivorship, pain, motion, and strength at a minimum of two years or until revision surgery. All 242 patients were considered for the analysis of 90-day, one-year, and overall mortality, medical complications (90-day and overall), surgical complications, and reoperations. The indications for surgery included rotator cuff arthropathy, osteoarthritis, fracture, the sequela of trauma, avascular necrosis, and rheumatoid arthritis. A retrospective review of the medical records was performed to collect all variables. Survivorship free of revision surgery was calculated at two and five years.

Results

One patient (0.4%) died within the first 90 days. A total of 45 patients (19%) were known to have died at the time of the final follow-up, with a median time to death of 67.7 months (interquartile range 40.4 to 94.7) postoperatively. Medical complications occurred in six patients (3%) and surgical complications occurred in 21/179 patients (12%). Survivorship free from revision was 98.9% at two years and 98.3% at five years; survivorship free from loosening was 99.5% at final follow-up. The presence of peripheral vascular disease correlated with a higher complication rate.

Conclusion

Primary RSA was safe and effective in patients aged > 80 years, with a relatively low rate of medical and surgical complications. Thus, age alone should not be a contraindication to primary RSA in patients aged > 80 years. However, a careful evaluation of comorbidities is required in this age group when considering primary RSA. Cite this article: Bone Joint J 2019;101-B:1520–1525
Lumbar disc herniation surgery in adolescents and young adults
Authors: Lagerbäck Tobias , Möller Hans , Gerdhem Paul
Published: December 2019

Aims

The purpose of this study was to investigate the risk of additional surgery in the lumbar spine and to describe long-term changes in patient-reported outcomes after surgery for lumbar disc herniation in adolescents and young adults.

Patients and Methods

We conducted a retrospective study design on prospectively collected data from a national quality register. The 4537 patients were divided into two groups: adolescents (≤ 18 years old, n = 151) and young adults (19 to 39 years old, n = 4386). The risk of additional lumbar spine surgery was surveyed for a mean of 11.4 years (6.0 to 19.3) in all 4537 patients. Long-term patient-reported outcomes were available at a mean of 7.2 years (5.0 to 10.0) in up to 2716 patients and included satisfaction, global assessment for leg and back pain, Oswestry Disability Index, visual analogue scale for leg and back pain, EuroQol five-dimension questionnaire (EQ-5D), and 36-Item Short-Form Health Survey (SF-36) Mental Component Summary and Physical Component Summary scores. Statistical analyses were performed with Cox proportional hazard regression, chi-squared test, McNemar’s test, Welch–Satterthwaite t-test, and Wilcoxon’s signed-rank test.

Results

Any type of additional lumbar spine surgery was seen in 796 patients (18%). Surgery for lumbar disc herniation accounted for more than half of the additional surgeries. The risk of any additional surgery was 0.9 (95% confidence interval (CI) 0.6 to 1.4) and the risk of additional lumbar disc herniation surgery was 1.0 (0.6 to 1.7) in adolescents compared with the young adult group. Both age groups improved their patient-reported outcome data after surgery (all p < 0.001). Changes between short- (mean 1.9 years (1.0 to 2.0)) and long-term follow-up (mean 7.2 years (5.0 to 10.0)) were small.

Conclusion

The risk of any additional lumbar spine surgery and additional lumbar disc herniation surgery was similar in adolescents and young adults. All patient-reported outcomes improved from preoperative to the short-term follow-up, while no likely clinically important differences between the short- and long-term follow-up were seen within both groups. Cite this article: Bone Joint J 2019;101-B:1534–1541
Analysis of macro and micro elemental composition of different extracts and finished products of the medicinal Herb – Terminalia bellirica
Authors: Gunasekar Conjeevaram J. , Abu-Yousef Imad A. , Narasimhan Srinivasan , Majdalawieh Amin F.
Published: December 2019

Terminalina bellirica is considered to be a sacred plant with five distinctive tastes (sweet, sour, salty, bitter, and pungent). It stimulates the proper functioning of the digestive system, sensory organs and it is very effective in treating several medical conditions. Four types of extracts were prepared (aqueous extracts of T. bellirica fruit, alcoholic extract of T. bellirica fruit, alcoholic extract of seed oil from T. bellirica nuts, and alcoholic extract of T. bellirica seed kernel). The elemental composition of T. bellirica was determined by ICP-OES. Macro elements like Ca (calcium), Na (sodium), and K (potassium) were found to be abundant in the studies samples. The quantity of Ca, Na, and K in the aqueous extracts of T. bellirica fruit, finished products of T. bellirica, alcoholic extract of T. bellirica fruit, alcoholic extract of seed oil from T. bellirica nuts, and alcoholic extract of  T. bellirica seed kernel was found to be (723.51-787.39, 347.80-478.90, 50.72, 120, and 300 mg/kg), (603.45-636.79, 241.76-370.00, 9.58, 180, and 200 mg/kg), and (151.23-165.73, 132.70-154.40, 4.26, 200, and 1,150 mg/kg), respectively. An Na/K ratio < 1.0 could prevent high blood pressure. The Na/K ratio in the alcoholic extract of T. bellirica fruit was found to be 0.51. Similarly, a Ca/P ratio > 1.0 is biologically relevant as a Ca/P ratio < 0.5 correlates with several health problems. The Ca/P ratio in the alcoholic extract of T. bellirica fruit was found to be 6.68. Hence, the measured Na/K and Ca/P ratios are in agreement with the recommended ratios. Our study supports the claims that T. bellirica extracts and finished products are of considerable therapeutic value for the prevention and/or treatment of various medical conditions. Moreover, the findings of our study will be helpful to ensure the quality and verify purification of natural products in different ayurvedic formulations.
Strategies to Foster Inclusion Through Sports: A Scoping Review
Authors: Grandisson Marie , Marcotte Justine , Niquette Béatrice , Milot Élise
Published: December 2019

This article presents the results of a scoping review on strategies that foster social inclusion of individuals with intellectual disability through sports. Five promising strategies were identified in 14 articles: 1) develop Unified Sports, 2) develop peer-support programs, 3) facilitate participation as an athlete in mainstream activities, 4) facilitate participation as a fan in mainstream activities, and 5) conduct activities to raise awareness. Their outcomes and key considerations for implementation are presented. Then, a model of social inclusion through participation in sports and physical activities is proposed as a mean to provide guidelines on how to provide a range of meaningful opportunities for sports participation in context(s) that are as inclusive as possible with enabling supports provided as needed.
“They Didn’t Even Realize Canada Was a Different Country”
Authors: Klein Candice
Published: December 2019

From 1 to 6 April 1971, over 600 women gathered to attend the Vancouver Indochinese Women’s Conference (viwc), an international women’s antiwar conference organized by women’s liberationists in Vancouver. The conference was intended to bring women together under the banner of an international sisterhood, but this desired goal did not happen. Instead, tensions between American and Canadian women divided conference organizers and attendees, culminating in verbal and physical conflict. The viwc is useful for examining how Canadian women experienced interactions with American feminists and radical activists in attendance at the conference. Several women viewed the actions of American delegates as imperialistic. The experiences of conference organizers and attendees show how the viwc represents a moment in women’s liberation where the limits to international feminism were particularly visible.

 

Du 1er au 6 avril 1971, plus de 600 femmes se sont réunies pour assister à la Conférence des femmes indochinoises de Vancouver (cfiv), une conférence internationale contre la guerre organisée par les défenseurs de la libération des femmes à Vancouver. La conférence avait pour but de rassembler les femmes sous la bannière d’une fraternité internationale, mais cet objectif souhaité n’a pas été atteint. En revanche, les tensions entre les femmes américaines et les femmes canadiennes ont divisé les organisateurs de la conférence et les participants, aboutissant à des conflits verbaux et physiques. La cfiv est utile pour examiner comment les femmes canadiennes ont vécu des interactions avec des féministes américaines et des activistes radicaux présents à la conférence. Plusieurs femmes ont considéré les actions des délégués américains comme impérialistes. L’expérience des organisateurs et des participants de la conférence montrent à quel point la cfiv représente un moment dans la libération des femmes où les limites au féminisme international étaient particulièrement visibles.
The Forgotten Work of Cultural Workers
Authors: Bischoping Katherine , King Adam D. K.
Published: December 2019

This paper is based on work history interviews with a group of nine Toronto theatre workers covering a three-year period. During the interviews, participants did not spontaneously mention 13.1 per cent of their jobs in the creative cultural sector. Because forgotten work fails to register in surveys attempting to assess cultural workers’ contributions to the economy or to ameliorate their precarious conditions, it is important to explore why and how such work could go unreported. We locate the forgetting of cultural work in relation to the complexity and stresses of cultural workers’ schedules and to a discourse that opposes a devotion to art to the pursuit of money. Further, we explore how the participants’ particular tendency to forget their shortest-term jobs is informed by another discourse that prioritizes the building of a goals-based, coherent résumé. Last, we suggest that their surprising propensity to also forget their longest-term jobs can be understood in reference to the “piecework” model of cultural work and to a lack of socially supported remembering strategies. Based on these findings, we recommend improvements to the design of surveys on cultural workers’ work history.

 

Ce document se base sur des entrevues de l’histoire du travail avec un groupe de neufs travailleurs de théâtre à Toronto, qui ont eu lieu dans une période de trois ans. Pendant les entrevues, les participants n’ont pas mentionné spontanément 13,1 pour cent de leurs postes dans le secteur culturel créatif. Comme les travaux oubliés ne parviennent pas à s’inscrire dans les sondages visant à évaluer les contributions économiques des travailleurs culturels ou à améliorer les conditions précaires dans leurs milieux de travail, il est important d’évaluer pourquoi et comment les travaux en question pourraient passer sans être déclarés. On associe l’oublie des postes au secteur culturel avec les nombreuses complexitées et stresses quant aux horaires irréguliers, et à un discours opposant le dévouement à l’art à la poursuite de l’argent. De plus, nous explorons le raisonnement des participants de prendre en compte l’importance de leurs postes de plus courtes durées, afin de ne pas nuire à l’allure d’un résumé cohérant centré seulement sur les objectifs ambitieux. En dernier lieu, on déduit que la propensité étonnante d’oublier également leurs postes de plus longs termes est dû au modèle de « travail à la pièce » et à un manque de stratégies socialement soutenus de mémoire. Avec ces résultats, nous recommandons des améliorations aux modèles de sondages sur l’historique de travail dans le secteur culturel.
Paraxial propagation of Pearcey Gaussian beams with the astigmatic phase in the chiral medium
Authors: Zeng Zishuai , Deng Dongmei
Published: December 2019

We introduce Pearcey Gaussian beams with the astigmatic phase (APPGBs) for what we believe is the first time and study their propagation in the chiral medium. APPGBs are split into the left and the right circularly polarized beams (LCP-APPGBs and RCP-APPGBs), of which we derive the analytical expression under the paraxial approximation. The results show that RCP-APPGBs have a longer autofocusing distance, which we can alter by adjusting the rotating factor or the chiral parameter. Besides, the increase of the rotating factor leads the autofocusing distances of both LCP-APPGBs and RCP-APPGBs to increase, while the increase of the chiral parameter leads to opposite effects on LCP-APPGBs and RCP-APPGBs. During propagation, the rotating factor can rotate the transverse intensity distribution, changing the rotation angular velocity. In addition, the rotating factor has a great impact on the phase distributions. Last, the effects of the rotating factor and the chiral parameter on the gradient force and the scattering force are analyzed.
Supernatural surveillance and blood-borne disease in Bram Stoker's Dracula: Reflections on mesmerism and HIV
Authors: Pheasant-Kelly Fran
Published: December 2019

Surveillance and/or voyeuristic viewing are central to certain horror productions and are often related to control and dominance. While such modes of looking are usually less obvious in the vampire film, the vampiric gaze nonetheless exerts a more definitive and immediate effect, causing its victims to fall prey to inevitable death and an extended afterlife. Although all vampire films tend to exploit these mesmeric aspects of Victorian culture, Bram Stoker's Dracula (1992), directed by Frances Ford Coppola, progresses the notion of 'supernatural surveillance'. Coppola uses numerous creative visual techniques to accentuate the attention to eyes, notably in scenes that are linked to sexual desire and promiscuity. If the original novel implicitly reflected contemporaneous fears of venereal infection, namely syphilis, then Coppola's film is preoccupied with AIDS. This essay argues that the film's attention to eyes and the gaze not only reflects the mesmerism associated with Victorian culture but also resonates with new forms of socio-cultural watchfulness emerging in the AIDS era of the twentieth century.
The flesh of the film: The camera as a body in neo-horror mockumentary and beyond
Authors: Surace Bruno
Published: December 2019

The neo-horror mockumentary, from the 1990s onwards, has been a genre in constant ascent, rejuvenating extremely codified strands. What unites these strands is undoubtedly a formal commonality since the premise of the genre is that of basing oneself on 'lucky' shots, which imitate a certain amateurism, while being also extremely corporeal. The neo-horror mockumentary treats the camera as a body in its own right, with its own potential and fragility, an actor like those it films. The body of the camera and the bodies filmed by it generate a dialectic of the flesh that makes the neo-horror mockumentary a body-based genre, irrespective of its articulations, which are examined in this essay from a semiotic perspective, which investigates the role of corporeality within the formal components of the genre, a filmographic perspective that through case studies identifies the system of variants and invariants around which the body becomes a pivot, and a philosophical perspective that frames the concept of body and its change in the imaginary within this new way of making cinema.
Dead but not gone: Female body, surveillance and serial-killing in Alfred Hitchcock's Frenzy
Authors: Mondal Subarna
Published: December 2019

Alfred Hitchcock in makes the corpse of an ordinary woman both an object of surveillance and a source of active watching. Mrs Bates and Marion in Psycho, Brenda and Babs in may be seen as predecessors to the series of dead women figuratively staring back in films such as The Silence of the Lambs () and Perfume: The Story of a Murderer (). The corpses do not merely offer themselves up as ciphers to be decoded. They reveal the lack in the perpetrators. Hitchcock's Frenzy relies on female bodies for clues to the murders. Hitchcock plays the vital role of bringing about a transition in the way in which women's bodies are to be treated in films, a transition from bodies shrouded by mist and darkness of the noirs to the exhibitionism of naked corpses in brightly lit settings. This article shows that abandonment of the usual tropes of visual impediments such as darkness and fog in Hitchcock's later films suggests a continually developing process of urban surveillance that aids in dehumanizing the victims. Further the post-murder masculinist investigative gaze forces a kind of mock-life on the victims through the relentless search of a killer's live signs on their dead flesh.
Diversity and prevalence of gastrointestinal parasites in farmed pigs in Southeast Gabon, Central Africa
Authors: Maganga Gael Darren , Kombila Linda Bohou , Boundenga Larson , Kinga Ivan Cyr Moussadji , Obame-Nkoghe Judicael , Tchoffo Herve , Gbati Oubri Bassa , Awah-Ndukum Julius
Published: December 2019

Background and Aim: Gastrointestinal infestations caused by intestinal parasites are the most important diseases and the most common in pigs in the tropics. These parasites are often associated with a huge economic loss. This study aimed to assess the diversity and prevalence of gastrointestinal parasites in farmed pigs from Haut-Ogooue Province, in South East Gabon.

Materials and Methods: From March 2018 to July 2018, 156 samples of pig feces collected from nine different farms were analyzed under light microscopy. The identification of eggs, cysts, and oocysts in fecal samples was done using two qualitative techniques: Flotation and sedimentation.

Results: After examination, the results obtained revealed an overall infestation level of 98.7% (154/156). We found ten parasite types with infestation levels that varied from species: Balantidium coli (120/156), Oesophagostomum spp. (100/156), Isospora suis (102/156), Ancylostoma spp. (17/156), Trichostrongylus spp. (28/156), Hyostrongylus spp. (13/156), Strongyloides spp. (7/156), Ascaris suum (8/156), Globocephalus spp. (1/156), and spirurida (1/156). The study of risk factors revealed that factors such as sex, age, and physiological condition may influence the diversity and level of infestation of animals by gastrointestinal parasites.

Conclusion: For better prevention of parasitism in these farms, it would be interesting to implement health monitoring and to ensure good hygiene. Finally, further studies would be needed to better evaluate the distribution of these parasites in Gabon and the involvement of these animals in the transmission cycle of parasitic zoonoses.
Az evidencialitás kifejezéseiről boszorkányperekben
Authors: Varga Mónika
Published: December 2019

A dolgozat az információ forrását és a tapasztalatból levonható következteté­seket jelölő kifejezések megítélésével, értékelésével foglalkozik a 16–18. szá­zadi boszorkányperes tanúvallomásokban, a fő forrás a Történeti magánéleti korpusz. A korszak tanúkihallgatási jegyzőkönyvei nem csak az aktuális tanúk különféle megfigyeléseit és vélekedéseit tartalmazhatják: a hatóság végezhetett újraértékelést, előtérbe helyezve a bizonyítást, a bizonyítékokat. Az értékelési folyamatot jóváhagyás és átfogalmazás egyaránt követhette, így kérdés, hogy mennyire egységesek az egyes források a bizonyítást tekintve, előtérbe kerül-e bennük a meggyőződés, az elfogultság a közösség vagy a hatóság részéről. A vizsgálat fő célja a forrásokból feltárt diskurzusstratégiák összehasonlító elemzése a jogi és társadalmi-kulturális kontextus bevonásával. A dolgozat módszertani problémákra is kitér, szembesítve a korpuszadatokat egy korábbi, formális jellegű leírással a boszorkányperes tanúvallomásokról.
Clinical Characteristics and Adverse Impact of Hepatotoxicity due to Immune Checkpoint Inhibitors
Authors: Miller Ethan D. , Abu-Sbeih Hamzah , Styskel Brett , Nogueras Gonzalez Graciela M. , Blechacz Boris , Naing Aung , Chalasani Naga
Published: December 2019

INTRODUCTION:

We conducted this study to characterize the incidence, clinical features, treatment, and outcomes of immune checkpoint inhibitor (ICI) hepatotoxicity.

METHODS:

Patients who received ICIs (with either single-agent or combination regimens) from January 1, 2010, to March 31, 2018, were identified. Hepatotoxicity was defined as alanine aminotransferase (ALT) >5 times the upper limit of normal (ULN), in the absence of an alternate cause, and categorized as grade 3 (ALT 5–20× ULN) or grade 4 (ALT >20× ULN), according to Common Terminology Criteria for Adverse Events 4.03.

RESULTS:

Among 5,762 patients, 100 (2%) developed hepatotoxicity, occurring in a higher proportion of recipients of combination therapy (9.2%) compared with monotherapy (up to 1.7%, P < 0.001). ICIs were discontinued permanently in 69 and temporarily in 31 patients. Sixty-seven patients received steroids, 10 of whom (14%) had recurrent hepatotoxicity after the steroid taper. Thirty-one patients resumed ICIs after ALT improvement, 8 of whom (26%) developed recurrent hepatotoxicity. Characteristics of liver injury, response to steroids, and outcomes were similar between 38 individuals with and 62 without possible pre-existing liver disease. The severity and outcome of hepatotoxicity due to combination therapy were not significantly different from monotherapy. There were 36 deaths. Two had liver failure at the time of death, both with progression of liver metastases and grade 3 hepatotoxicity.

DISCUSSION:

Clinically significant ICI-related hepatotoxicity was uncommon but led to permanent ICI discontinuation in the majority. ICIs were restarted in a sizable proportion of patients, most of whom did not experience recurrent hepatotoxicity.
ACOUSTIC EMISSION TRANSDUCER'S FEATURES OF CHARACTERISTICS AND PARAMETERS
Authors: Sazonov A. A.
Published: December 2019

The article describes comparative analysis of transducers operation, which used in ultrasonic, vibration, acoustic emission methods. The analysis of differences and similarities has made after the comparison of parameters between piezo-transducers. The comparison of transducers allows you to take a fresh look at their work, characteristic features and problems. Solution of these problems requires priority attention.
KAJIAN RUANG DAN AKTIVITAS PASAR MINGGU TAMAN SETIABUDI BANYUMANIK TERHADAP TERBENTUKNYA KOHESI SOSIAL MASYARAKAT
Authors: Pramesti Previari Umi , Prabowo Bintang Noor , Hasan Muhammad Ismail
Published: December 2019

Kohesi sosial adalah sebuah perekat yang secara fungsional merupakan kristalisasi dari adanya kesamaan famili, klan, etnik, kesamaan nasib, jenis pekerjaan, orientasi budaya, dan tujuan sosial. Dalam sudut pandang ini, terbentuknya sebuah masyatakat harus melalui mekanisme penyatuan berbagai kesamaan yang disebut di atas. Dengan kalimat lain, pembentukan sebuah masyarakat harus melalui mekanisme perekatan yang disebut kohesi sosial. Pasar  Minggu Taman Setiabudi Banyumanik adalah salah satu fenomena sosial yang ada di wilayah Semarang Atas dimana terdapat aktivitas ekonomi yang secara tidak langsung memfasilitasi terciptanya aktivitas sosial masyarakat setempat. Analisis Teori Produksi Ruang Henri Lefebvre digunakan sebagai alat untuk membaca kondisi di lapangan.Hasil penganalisaan diketahui bahwa kohesi sosial di Pasar Minggu Taman Setiabudi ini merupakan sinergi suatu interaksi dinamis antara proses sosial dan proses spasial, berupa tata ruang, perkembangan masyarakat urban, ruang publik, dan berbagai ekspresi budaya yang muncul atas berbagai praktek ‘menghuni’ suatu ruang
OPTIMALISASI BUKAAN DAN KENYAMANAN RUANG MELALUI ANALISIS OTTV DAN SUN SHADING
Authors: Wibawa Baju Arie , Hutama Alif Nur
Published: December 2019

The window as the opening of natural lighting is more critical to conserve building energy, but if the size opening is too broad will increase the solar heat into the room. Over of heat, will also cause discomfort in the place because the value of OTTV (overall thermal transfer value) will also increase. The purpose of this study is to identify components, calculate the OTTV value and the analysis of shadow of the sun into the room. In the meeting room of the UPGRIS post-graduate building, there is too many windows that make the room glare and hot. It is felt to affect inefficient artificial energy (Air Conditioning). The method used is a type of quantitative research with an experimental approach. The results of the OTTV study in this room is 52.33 watts/m2, and this is exceeded from SNI (35 watts/m2). This research redesign of windows and shading to comply with maximum standard.
Manifesto of the Epicurean Philosophy of Life
Authors: Wesoły Marian Andrzej
Published: December 2019

Epicurus’ philosophy grew out of his life experiences, contacts, polem­ics, journeys and other activities. Apart from such great works as the monumental On nature (Peri phuseôs) in 37 books, Epicurus authored also various extracts (epitomai), principle doctrines, sayings and letters. The letters, while addressed to many students and friends, were for him a very important tool of propagating his own philosophy. Epicurus’ fascinating Letter to Menoeceus can be regarded as a manifesto of his philosophy of life. In historiography, it is often characterized as an expo­sition of his ethics, even though Epicurus probably did not use the term himself. To better capture the composition and spirit of this work, the Greek text of the letter has been somewhat rearranged here: for the sake of clarity, ample spaces and special paragraphs have been provided, and appropriate headings have been introduced in the Polish translation.
A New Architecture of Energy Hubs for Animal Farms with Distributed Energy Resources
Authors: Nguyen Minh Y , Thuy Pham Dieu
Published: December 2019

This paper presents a new architecture of energy hubs for animal farms considering the availability of energy resources in the farm such as biogas, solar, etc. It is proposed to combine three energy carriers: biogas, heat and electricity into an aggregate system to improve the energy efficiency of the farm. The problem is to determine the optimal allocation of distributed energy resources such as biogas generators, photovoltaics, battery and electric grid, etc. with the objective function is minimizing the total cost of energy hubs, i. e. life cycle cost while subjected to the constraint of heat, electricity and gas demands. The uncertainty of renewable energy is taken into account not only with the daily and monthly variation of the resource but the forecasting error as well. In addition, the sensitivity of the life cycle cost with respect to the price of electricity is analysed in different scenarios. The problem is examined in a case study of a typical pig farm in Northern Vietnam in both cases: with and without the ability to sell the surplus electricity to the grid. The simulation result shows the effectiveness of the proposed energy hub compared to other approaches.
Optimizing Thermal Processing of Broccoli: Model Development, Numerical Simulation, Experimental Validation
Authors: Pero Milad , Kiani Hossein , Skåra Torstein , Skipnes Dagbjørn , Askari Gholamreze
Published: December 2019

Kinetic models describing the thermal inactivation of peroxidase and degradation of broccoli (Brassica Oleracea var. Italica) color were coupled with heat transfer equation (2D conductive heat transfer in cylindrical packed broccoli samples), and their simultaneous numerical simulation followed by experimental validation was carried out. Obtained results revealed that modeling the rate constants of the reactions with log logistic equation provides a better prediction in comparison with the most popular Arrhenius equation. It was observed that processing at temperatures lower than 80 °C is not recommended for processing of broccoli due to its adverse effect on the color of samples and considerable longer process time needed for assuring sufficient inactivation of enzyme at the cold spot. Temperatures above 80 °C were suitable for this purpose because the process time needed for inactivating peroxidase at the cold spot of sample not only affected the green color of samples negatively, but oppositely it resulted in a higher greenness than the original value.