bluuebunny/crossref_metadata_2025 huggingface dataset:
Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women
Authors: Yokoyama Akira , Yokoyama Tetsuji , Kimura Mitsuru , Matsushita Sachio , Yokoyama Masako
Published: July 2021

Objective

The risk of alcohol dependence (AD) in Japanese men and women was evaluated according to combinations of alcohol flushing andaldehyde dehydrogenase-2(ALDH2, rs671) andalcohol dehydrogenase-1B(ADH1B, rs1229984) genotypes, all of which are known to determine AD susceptibility in Asians. Previous studies have focused on men, since women account for a smaller proportion of AD subjects.

Methods

Case control studies were conducted between 3721 male and 335 female AD Japanese and 610 male and 406 female controls who were asked about their current or former tendency to experience facial flushing after drinking a glass of beer and underwentALDH2andADH1Bgenotyping. The time at which alcohol-induced facial flushing tendencies had disappeared in former-flushing AD subjects was also evaluated.

Results

Current alcohol flushing, the inactiveALDH2*1/*2genotype, and the fast-metabolizingADH1B*2allele were less frequently found in the AD groups. Although alcohol flushing was strongly influenced by theALDH2andADH1Bgenotypes, multiple logistic model showed that never or former flushing and the genotype combinations were independent strong risk factors of AD in men and women. Never or former flushing (vs. current flushing) markedly increased the odds ratios of AD in carriers of each of theALDH2andADH1Bgenotype combinations. The temporal profiles for drinking and flushing in former-flushing AD subjects revealed that the flushing response disappeared soon after or before the start of habitual drinking during young adulthood, regardless of theALDH2genotype.

Conclusion

Although alcohol flushing is influenced by theALDH2andADH1Bgenotypes, constitutional or acquired flushing tolerance is an independent susceptibility trait for AD. The combination of the alcohol flushing status and theALDH2andADH1Bgenotypes can provide a better new strategy for AD risk assessment than the alcohol flushing status alone or the genotypes alone in Asian men and women.
Aproximación al perfil sociodemográfico y comportamiento del asistente a rallies
Authors: Rico Bouza Cristina , Araújo Vila Noelia , Fraiz Brea Jose Antonio
Published: July 2021

Los deportes de motor se constituyen como una de las modalidades deportivas con mayor número de adeptos. Los eventos automovilísticos en Galicia son reconocidos a nivel estatal por su excelente calidad, con un alto número de asistentes. Los rallies se establecen como la modalidad con mayor número de espectadores, lo que convierte a estas pruebas en un importante elemento dinamizador y desestacionalizador, celebrándose a lo largo de todo el año. El presente trabajo parte de la relevancia de estos eventos y pretende realizar una aproximación al perfil sociodemográfico y comportamiento turístico de los asistentes a rallies en Galicia. Para ello se recogen un total de 504 encuestas a asistentes a dichos eventos en el noroeste de España, concluyéndose que la mayoría de la población de estudio (alrededor del 44%) tiene un alto grado de fidelidad en cuanto a la asistencia a las pruebas automovilísticas (rallies de asfalto en particular).
Empoderamiento en el turismo rural. Propuesta de un instrumento de medición
Authors: González Domínguez Irais , Osorio García Maribel , Delgado Cruz Alejandro
Published: July 2021

El objetivo del artículo es validar un instrumento de medición del empoderamiento en el contexto del turismo rural en comunidades indígenas. El instrumento se aplicó a 91 miembros de nueve comunidades rurales del Estado de México, México. Para ello, se verificó la confiabilidad y la validez a través de coeficientes de consistencia interna y el análisis compuesto de confirmación. El instrumento reflejó una excelente consistencia interna global y la estructura factorial develó cuatro tipos de empoderamiento: psicológico, político, social y económico validando su pertinencia de medición. La aportación permite consolidar la teoría del empoderamiento en grupos o comunidades dedicadas a la prestación de servicios turísticos en entornos rurales. Asimismo, se concluye que la validación de instrumentos facilita y proporciona insumos a las nuevas investigaciones para replantear y explicar el comportamiento del fenómeno cuando se presenta en otras realidades.
Recreación del espacio europeo de educación superior en el horizonte de la sociedad de la sabiduría: hacia un nuevo escenario docente
Authors: Jover Gonzalo , González Geraldo José Luis
Published: July 2021

El Espacio Europeo de Educación Superior (EEES) derivado del conocidoproceso de Bolonia, ha llegado a su fin. No obstante, su instauración ha traído consigola implantación definitiva de la no menos conocida Sociedad del Conocimiento y lademocratización de las Tecnologías de la Información y la Comunicación (TIC) enel ámbito educativo. Todos estos cambios han sido imprescindibles para consumar elpaso del saber al saber hacer y, con él, mejorar la calidad de la educación superior.En estas líneas replanteamos las características del mencionado cambio para tratar decomprender cuál podría, o debería, ser el siguiente objetivo a conseguir. De esta forma,abogamos por avanzar hacia una “Sociedad de la Sabiduría” que permita afianzar elconocimiento en postulados éticos y morales que nos ayuden a conseguir competentesprofesionales, sin duda, pero también personas críticas y comprometidas que valoren,ante todo, el saber ser y estar.
La eticidad de las TIC. Las competencias transversales y sus paradojas
Authors: Burguet Marta , Buxarrais Mª Rosa
Published: July 2021

Los sistemas educativos en la era de las nuevas tecnologías conllevan una revolución en los procesos de aprendizaje tradicionales. Para una buena implementación de estos cambios, el profesorado debe formarse en ‘nuevas’ competencias de carácter ético, que confieren sentido a las competencias digitales, una formación que conlleva una nueva forma de entender la pedagogía: donde los estudiantes adquieren protagonismo y autonomía para obtener, por ellos mismos, respuestas a los interrogantes. Una implementación transversal, en las aulas, de ambas tipologías de competencias nos desvela ciertas paradojas que la educación actual debe asumir como retos de presente y futuro.
Synthesis and Antimicrobial Activity of 2-(4-Phenyl-2H-chromen-3-yl)-1H-benzo[d]imidazole
Authors: Dasari Ramachandraiah , Thalari Gangadhar , Yerrabelly Jayaprakash Rao , Chitneni Prasad Rao
Published: July 2021

A new series of 4-phenyl-2H-chromene-3-benzimidazoles (8a-o) were synthesized by the condensation
of 4-phenyl-2H-chromene-3-carbaldehyde with o-phenylene diamines. The products were purified
through column chromatography and structures of these compounds were characterized by IR, 1H &
13C NMR and mass spectral data. All the final compounds were screened for their antimicrobial activity
and their efficacy were matched with ciprofloxacin. Five compounds (8b, 8d, 8i, 8l and 8o) were
found to be most effective compounds of this series and with activities improved than ciprofloxacin
under the tested conditions
Poly 4-Vinylpyridine and Polystyrene Based Interpenetrating
Polymer Networks (IPNs): Synthesis and Characterization
Authors: Mishra Dayanand , Kamal Meet
Published: July 2021

A study on synthesis of thin film of interpenetrating polymer network (IPN), of poly(4-vinylpyridine)
(PVP) and polystyrene was carried out. A series of IPN was synthesized, using divinyl benzene (as
cross linker) and benzoyl peroxide (as an initiator) and characterized using FT-IR spectroscopy, scanning
electron microscopy (SEM), thermal (DSC, TGA) and fluorescent techniques. FTIR spectra revealed the
presence of PVP at 1584 cm–1 and polystyrene at 1609 cm–1. Shifting in band positions depicts formation
of IPN. SEM images show a clear dual phase morphology. DSC thermogram reveals glass transition
temperature (Tg) value of the polymer network at 350 ºC. TGA graph depicts thermal stability of IPN
upto 400 °C. The XRD pattern of IPN indicates semi crystalline nature. The properties such as average
molecular weight between crosslinks (Mc), percentage swelling is found to be the direct function of
initiator (BPO) and inverse function of concentration of cross linker (DVB) and styrene. Fluorescence
spectra of IPN observed in visual range of 506 nm.
Synthesis, Crystal Structure, Hirshfeld, DFT,
Quorum Sensing Inhibition and Molecular Docking Studies of
N'-{(E)-[3-(3,5-Difluorophenyl)1H-pyrazol-4-yl]methylidene}-4-methoxybenzohydrazide
Authors: Kumar Vasantha , Ganavi D. , Kumar B. Sukesh , Shastry Rajesh P. , Kumar A.H. Udaya , Kumar S. Madan , Al-Ghorbani Mohammed , Swamy P.M. Gurubasavaraja , Lokanath N.K. , Naveen K. , Poojary Boja
Published: July 2021

In present study, the synthesis, structural, quorum sensing inhibition and computational studies of a
new N’-{(E)-[3-(3,5-difluorophenyl)-1H-pyrazol-4-yl]methylidene}-4-methoxybenzohydrazide are
reported. The structure of the synthesized compound was confirmed by IR, 1H & 13C NMR and mass
spectral data. The single crystals of the compound was obtained using ethanol as a crystallization
solvent. The synthesized compound (C40H40N8O6F4) crystallizes in the monoclinic crystal system, C2/c
space group. Various intermolecular interactions were quantified using a 3D molecular Hirshfeld surface
computational method. The 2D fingerprint plots revealed that the H···H (35.9%) interactions have a
major contribution to the total molecular surface. DFT studies was performed to establish the molecular
crystal structure of the compound and to study the HOMO-LUMO energies of the compound. The
anti-quorum sensing study of the target compound on Chromobacterium violaceum (wild type) biosensor
revealed that quorum quenching activity at 300 μg/mL. Interestingly, quantitative assay exhibited
more than 80% of quorum sensing inhibition without interfering cell growth (p < 0.05). Molecular
docking studies of the compound on CviR protein (PDB: 3QP8) confirmed the observed activity
through strong hydrogen bonding interaction with the amino acids in the binding pocket.
Synthesis, Spectroscopic Properties and Hirshfeld Surface Analysis of
3,14-Dimethyl-2,6,13,17-tetraazoniatricyclo(16.4.0.07,12)docosane Tetrachloride Tetrahydrate
Authors: Jeon Sunghwan , Moncol Ján , Mazúr Milan , Valko Marián , Ryoo Keon Sang , Choi Jong-Ha
Published: July 2021

Single crystals of 3,14-dimethyl-2,6,13,17-tetraazoniatricyclo(16.4.0.07,12)docosane tetrachloride
tetrahydrate compound, [C20H44N4]Cl4·4H2O (1), were obtained by a novel synthetic route and
characterized by elemental analysis and X-ray diffraction. The synthesized compound crystallized in
the monoclinic space group P21/n with two molecules of compound 1 in the unit cell [a = 7.5548(3) Å,
b = 23.1838(8) Å, c = 8.3101(4) Å; β = 103.390(3)º]. The asymmetric unit contains half a
centrosymmetric macrocyclic cation, two chloride anions and two water molecules. The organic
[C20H44N4]4+ fragment of 1 adopts an exodentate [3,4,3,4]-D conformation. The C–C and N–C bond
lengths of the macrocyclic tetracation range 1.525(3)-1.540(3) Å and 1.505(3)-1.519(3) Å, respectively.
A three-dimensional hydrogen bonding network provides crystal cohesion through O–H···Cl, N–H···Cl
and N–H···O interactions between organic cations, chloride anions and water molecules. The functional
groups present in the crystal were studied by Fourier-transform infrared spectroscopy and Raman
spectroscopy. The Hirshfeld surface analysis and 2D fingerprint plots revealed that the crystal packing
in 1 is dominated by H···H, Cl···H/H···Cl and O···H/H···O contacts.
Synthesis and Cytotoxic Studies of Pyrrolopyrimidine Derivatives
Authors: Roopashree Rangaswamy , Swaroop Toreshettahally R. , Shivaprasad Chalya M. , Jagadish Swamy , Rangappa Kanchugarakoppal S.
Published: July 2021

The synthesis and in vitro cytotoxicity of new pyrrolopyrimidine derivatives is reported in this work.
All the compounds were characterized by IR, NMR and MS. They are examined for cytotoxic activity
against HeLa. Pyrrolopyrimidine derivatives of benzyl amine (8g) and 4-bromoaniline (8k) showed a
potent activity, which is comparable to that of standard Sorafenib.
Synthesis, Characterization and Biological Evaluation of Metal(II) Complexes Containing
Triphenylphosphine and Schiff Base Ligand Based on 3-Methoxysalicylaldehyde
Authors: Gokulnath G. , Anitha P. , Manikandan R. , Umarani C.
Published: July 2021

Schiff base ligand (HL) derived from condensation of 3-methoxy salicylaldehyde with 4-aminobenzoic
acid and its metal(II) complexes containing triphenylphosphine of the type [MCl(PPh3)(L)] (M = Ni2+,
Co2+ or Cu2+; L = bitendate Schiff base ligand) have been synthesized. All the metal(II) complexes
were characterized by analytical and spectroscopic (FT-IR, electronic, ESI-Mass, ESR, 1H, 13C NMR
and 31P NMR) techniques. All the synthesized compounds were evaluated for in vitro antimicrobial
efficiency against Gram-positive bacteria, Gram-negative bacteria and fungai using the agar well
diffusion method. Anticancer activity in vitro of the ligand and its metal(II) complexes were also
screened against MCF-7 cancer cell lines (human breast cancer cell line).
Estadsticas actuales de la subfamilia Poeciliinae Bonaparte, 1831
Authors: nava mauricio
Published: July 2021

La subfamilia Poeciliinae Bonaparte 1831 comprende un grupo de peces distribuido en América del norte, desde Estados Unidos hasta el norte de Argentina, que ha sido largamente estudiado en diversos aspectos de la ciencia. Para una comprensión integral de los Poeciliinae se realizó un análisis estadístico de los datos más importantes sobre ésta subfamilia. Ésta información permitirá a la comunidad científica y a los administradores de recursos biológicos tomar decisiones encaminadas a desarrollar líneas de investigación en aquellas especies o temáticas poco estudiadas.
Use of e-health in general practices during the covid-19 pandemic
Authors: Keuper Jelle
Published: July 2021

Background and purpose – The covid-19 pandemic has forced general practices to look for ways to deliver care safely, by the use of remote healthcare solutions such as e-health. The aim of this study is to investigate the use of e-health in general practices during the COVID-19 pandemic, and theintention of general practices to continue using e-health tools more intensively in the near future.

Methods – Web surveys were sent to all Dutch general practices at two moments during the pandemic: in April 2020, during the first wave of the pandemic in the Netherlands, and in July 2020, between the first and second wave, when infection numbers were lower. The surveys contained questions on the use of specific e-health tools, including e-consultations and video calling.

Results – 75%of the general practices indicated that the COVID-19 pandemic caused them to start using e-health applications or made them to intensify these in April 2020. In July 2020, almost all practices indicated that they used at least one e-health application (98%). Online prescriptions ordering service and e-consultations were used by more than 80% of all practices. However, a minority of practices (<33%) answered that they intend to use (new) e-health applications more intensively after the pandemic. Some significant differences were found in the use of specific e-health applications between different practice types.

Conclusions – This study confirms the expectation that there was an increased uptake of e-health applications in Dutch general practices during the COVID-19 pandemic. The relative low number of practices that intend to sustain the increased usage of e-health in their practice in the future may point towards a temporary uptake of digital health care delivery, rather than accelerated implementation of digital processes.
Association of the rs2167270 polymorphism of the leptin gene (LEP) with the intensity of pain in patients with osteoarthritis of the knee
Authors: Krylov M. Yu. , Alekseeva L. I. , Scharapova E. P.
Published: July 2021

Background: Osteoarthritis (OA) is a significant social problem as it is the most common disease of the joints. OA is a multifactorial disease in which great attention is paid to hereditary factors. Recently, a number of studies have demonstrated the contribution of a number of genes to the subjective assessment of pain in OA, which is the main symptom of this disease. The association of P2X7, TRPV1 and TACR1 genes and some others with pain sensitivity has been shown. One of the risk factors of pain among many others, is the increased weight. Abdominal adipose tissue is a source of release of pro-inflammatory adipokines that cause systemic inflammation associated with damage to many tissues, including subchondral bone, synovial membrane. Leptin is an endogenous hormone from the adipokine family encoded by the obesity gene leptin (LEP) and which is synthesized primarily in adipocytes.

Aims: To investigate the possible association of rs2167270 (A19G) polymorphism of the LEP gene with pain intensity in ­patients with knee OA.

Materials and methods: The study was conducted among women diagnosed with OA. Using the VAS scale (Visual analog scale), patients with mild knee pain — group 1 (VAS ≤ 40 mm) and patients with moderate or severe pain — group 2 (VAS>40 mm) were selected for pain assessment. Genetic variants of A19G leptin gene polymorphism were studied by polymerase chain reaction followed by restriction fragment length analysis (PCR-RFLP) method.

Results: In the group of patients with moderate or severe pain intensity (group 2, n=61), a statistically significant association was shown with a higher body mass index (p=0.006) and an increased frequency of carriers of the 19GG genotype (p=0,051) compared to group 1 (n=36). Carriers of the 19GG genotype statistically significantly had a higher rate of knee pain and an early age of OA debut compared to carriers of the 19AA genotype (p=0,035 and p=0,015, respectively).

Conclusions: The findings open up new possibilities for predicting pain symptoms in patients with knee OA by genetic testing of A19G polymorphic variants of the leptin gene.
The influence of adiponectin on carbohydrates, lipids, and lipoproteins metabolism: analysis of signaling mechanisms
Authors: Tanyanskiy D. A. , Denisenko A. D.
Published: July 2021

Dysregulation of adipose tissue functions makes a significant contribution to the pathogenesis of metabolic syndrome, one of the most common diseases in recent years. Adipose tissue is an organ that secretes at least several dozen signaling molecules, adipokines. One of the most studied and at the same time mysterious adipokines is adiponectin. The latter is due to the lack of clear ideas about the biological role of this adipokine, the presence of its several molecular forms with different activity and several types of receptors to this adipokine localized in almost all cells of the body. The purpose of this review is to summarize and analyze the available information about the molecular mechanisms of the effect of adiponectin on metabolism of carbohydrates, lipids and lipoproteins. The literature search was conducted by the keywords "adiponectin" and "metabolic syndrome" in the Pubmed and Elibrary.ru databases for the period from 1995 to 2021.

According to the results of the literature analysis, it is assumed that adiponectin is involved in energy metabolism as a «satiety» hormone that promotes the utilization and storage of energy-rich substrates, fatty acids and glucose, which prevents the development or mitigates the already developed insulin resistance. This reduces the amount of plasma triglycerides and increases the level of high-density lipoproteins in the plasma. Adiponectin affects metabolic processes by activating the AdipoR1-APPL1-LKB1-AMPK, AdipoR1-APPL1-p38, AdipoR2-PPARa cascades, and possibly by activating the ceramidase and phosphoinositide pathways and insulin signaling. In addition to the AdipoR1/2 receptors, the adhesion molecule T-cadherin may be involved in the transduction of the adiponectin signal in endothelial and muscle cells. The mechanisms of signal transduction from T-cadherin, as well as from AdipoR2, remain unclear. Studies on the mechanisms of the action of individual molecular forms of adiponectin are extremely rare. The analysis shows the complex nature of adiponectin signaling, many of the mechanisms of  which remain undiscovered, and it is possible that the near future will bring us significant progress in this area.
Ekspansi Israel Atas Yerussalem dalam al-Qur’an: Tinjauan atas penafsiran Q 5: 20-26 dalam Tafsīr al-Sha‘rāwī
Authors: Syahputra Satria Tenun
Published: July 2021

Artikel bertujuan untuk menemukan konsepsi al-Sha’rāwī tentang ekspansi Israel atas Yerussalem dalam penafsirannya terhadap Q 5: 20-26. Konflik yang berlangsung antara Israel dan Palestina merupakan konflik yang rumit yang argumentasinya mengarah pada persoalan keagamaan. Persoalan ini membutuhkan analisa ilmiah untuk membantah tindakan tidak humanis tersebut, dengan menggunakan penelitian kualitatif (library Research) dengan metode pendekatan analisis kritis-historis, yang terfokus kepada kitab Tafsīr al-Sha’rāwī. Tafsir ini merupakan salah satu tafsir yang mengedepankan aspek bahasa dan kemukjizatan al-Quran dengan mengaktualisasikan penafsirannya dengan kondisi terkini. Penelitian ini menyimpulkan bahwa klaim historis yang dilakukan Israel untuk mendirikan negara di tanah Palestina merupakan klaim yang tidak berdasar. Al-Qur’an memberikan dasar atas argumentasi tersebut yang dijelaskan dan diungkapkan oleh al-Sha’rāwī. Ketetapan Allah untuk memberikan tanah suci Yerussalem kepada umat Yahudi, dalam al-Qur’an merupakan irādah Tashrī’īyah, bukan irādah kawniyah. Dengan konsep tersebut, untuk menyelesaikan konflik yang terjadi diperlukan kriteria-kriteria khusus yang bergantung pada keinginan dan kemampuan umat Islam agar mendapatkan wa’du al-akhirah yang merupakan bentuk qadiyah Quraniyah yang belum terbukti secara empiris keseluruhannya.
Urgensi Ma’na-Cum-Maghza di Era Kontemporer: Studi Penafsiran Sahiron Syamsuddin atas Q 5: 51
Authors: Firdausiyah Umi Wasilatul
Published: July 2021

Artikel ini membahas tentang urgensi pendekatan ma’na-cum-maghza di era kontemporer yang digagas oleh Sahiron yang diimplementasikan pada Q 5: 51. Kehadiran pendekatan ini sebagai alternatif baru dalam penafsiran kontekstual mengalami perdebatan tentang keabsahannya. Untuk melakukan pengujian terhadap kontribusi pedekatan ini dalam penyelesaian problem aktual yang menjadi dasar dari keberadaan tafsir kontektual, maka penelitian ini menggunakan metode content analysis dengan jenis penelitian studi pustaka. Penelitian ini menyimpulkan bahwa terdapat tiga sumbangsih yang diberikan oleh pendekatan ma’na-cum-maghza. Pertama, dalam wilayah metodis, penelitian ini memberikan penyempurnaan terhadap konsep tafsir kontekstual sebelumnya dengan memberikan makna kontekstual terhadap setiap jenis ayat, tanpa membatasi pada ayat hukum saja. Kedua, dalam wilayah fungsi interpretasi, pendekatan ini memberikan kontribusi langsung atas petunjuk al-Qur’an sebagai landasan dalam mengatasi problematika aktual yang dihadapi masyarakat muslim, khusunya di Indonesia. Ketiga, dalam wilayah pengembangan kajian al-Qur’an, pendekatan ini memberikan alternatif metode baru dalam memahami ayat secara aktual yang dihasilkan dari kekurangan dari metode sebelumnya, sehingga dinamika dalam kajian al-Qur’an terus berkembang. Keberadaan pendekatan ma’na-cum-maghza dengan demikian menjadi pelengkap dan penyempurna metode penafsiran kontekstual yang memiliki sumbangsih besar dalam memahami al-Qur’an yang relevan dengan perkembangan dan problematika masyarakat kontemporer.
Literature analysis on product-service systems business model: a promising research field
Authors: Moro Suzana Regina , Cauchick-Miguel Paulo Augusto , Mendes Glauco Henrique de Sousa
Published: July 2021

Goal: Product-service system (PSS) is a business model implemented by organizations aiming at generating profitability and competitiveness, and contributing to sustainability. However, companies need to build up new skills to develop and implement PSS focused on business models that should be able to generate value. This context calls for a theoretical analysis with the objective of identifing characteristics of this type of business model by means of a literature review.
Design/Methodology/Approach: A descriptive review was conducted, and 313 publications related to PSS business model were selected. A final set of 48 articles related to PSS and business models were identified as well as the number of publications per year and main journal. Mechanisms for generating value from the PSS business model and its components were described after content analysis.
Results: Most of PSS business model publications were published in recent years with the main focus on sustainability. Fourteen business model components were identified from the literature to be considered when structuring a PSS, associated with value proposition, creation, delivery, and value capture mechanisms. The most common components were ‘value proposition’ and ‘key partners’, although their concepts need a clarification. The business model should be designed with a value-centric vision in an iterative process. Moreover, it must cover the interests of the entire PSS value network, considering environmental, economic, and social dimensions of sustainability.
Limitation of the investigation: The analysis has not considered the related research field on servitization, and nor the publications related to the ‘value’ concept from interdisciplinary areas (e.g., marketing).
Practical implications: Developing a PSS business model requires forming a value network, considering the interests and responsibilities of those involved for the generation of mutual value as well as the inter-organizational relationships.
Originality/Value: As PSS as a business model is a promising field of study, this paper devotes more attention on developing this kind of business model.
The seamless web of next generation sequencing and Covid-19
Authors: Kastenhofer Karen
Published: July 2021

“When is Covid Covid?” is the title of a discussion paper published by the Centre for Evidence-Based Medicine at Oxford University on 11 September 2020. Amid the multinational struggle for an appropriate social and political approach to the crisis triggered by Covid-19, a recognized panel of medical experts alerts us that Covid-19 is defined very differently in different contexts. One definition focuses on symptoms, another one on RNA sequences of the virus. In the present contribution, this debate is taken up to discuss the extent to which new sequencing practices and their “seamless webs” become socially effective as instances of interpretation and design. At the same time, the limitations of such webs become noticeable as ruptures, seams, and scars.
Technikvertrauen
Authors: Weydner-Volkmann Sebastian
Published: July 2021

Der Beitrag lotet aus, inwiefern über den Begriff „Technikvertrauen“ komplementär zu den in der Technikfolgenabschätzung bereits etablierten Begriffen „Akzeptanz“ und „Akzeptabilität“ ein konzeptueller Beitrag für eine ethische Technikbewertung geleistet werden kann. Es wird gezeigt, dass gerade für Digitaltechniken Aspekte der Angriffssicherheit besser adressiert werden können, weil hier an die Begrifflichkeiten der IT-Sicherheitsforschung angeschlossen werden kann. Zudem erlaubt „vertrauenswürdige Technik“ eine bessere Einbeziehung von Laienperspektiven, da ein rational begründetes Vertrauen im Sinne von Risikoerwartungen interpersonell durch Expertisen vermittelt werden kann. Insbesondere für die Bewertung von Digitaltechniken kann „Technikvertrauen“ somit eine Lücke zwischen Akzeptanz und Akzeptabilität schließen.
Die Welt verändern wir nur gemeinsam
Authors: Nanz Patrizia , Weinberger Nora , Woll Silvia
Published: July 2021

Bürgerinnen und Bürger werden zunehmend an der Gestaltung von Wissenschaft, Politik und Technologie beteiligt; es ist eine „partizipatorische Wende“ zu beobachten, die die wichtige Rolle von deliberativen Verfahren betont. Auch Patrizia Nanz fordert in diesem Interview, Bürgerinnen und Bürger in Verantwortung zu bringen, da ihrer Ansicht nach, den zukünftigen komplexen Herausforderungen nur im Kooperationsmodus begegnet werden kann. Gemeinsam mit Bürgerinnen und Bürgern müsse in dialogorientierten Verfahren entschieden werden, wie wir zukünftig (nachhaltiger) leben wollen. Expertenwissen alleine reiche, beispielweise bei der Suche nach einem Standort für ein Endlager für hochradioaktive Abfälle, nicht aus.
The mixed metric dimension of flower snarks and wheels
Authors: Danas Milica Milivojević
Published: July 2021

New graph invariant, which is called a mixed metric dimension, has been recently introduced. In this paper, exact results of the mixed metric dimension on two special classes of graphs are found: flower snarks

J

n

{J}_{n}

and wheels

W

n

{W}_{n}

. It is proved that the mixed metric dimension for

J

5

{J}_{5}

is equal to 5, while for higher dimensions it is constant and equal to 4. For

W

n

{W}_{n}

, the mixed metric dimension is not constant, but it is equal to

n

n

when

n
≥
4

n\ge 4

, while it is equal to 4, for

n
=
3

n=3

.
Партийно-политическая система Германии в период канцлерства А. Меркель (2005–2017 гг.)
Authors: Timoshenkova Ekaterina
Published: July 2021

Монография представляет собой комплексное исследование партийно-политической системы Германии в период канцлерства А. Меркель с 2005 по 2017 гг. Автор анализирует особенности стиля управления А. Меркель, её политику как канцлера ФРГ и председателя ХДС, выявляет основные тенденции трансформации германских политических партий: ХДС, ХСС, СДПГ, СвДП, «Союза 90/Зелёные», «Левой», «Альтернативы для Германии». Особое внимание в работе уделено анализу избирательных кампаний и итогов выборов в бундестаг и земельные ландтаги. Дан прогноз развития партийно-политической системы Германии в будущем, исходя из итогов деятельности А. Меркель.
Implementation of Fuzzy Logic Controller for Pressure Sensor Calibration Chamber
Authors: Ridwan M. , Taryo T.
Published: July 2021

Atmospheric pressure is a weather element that must be observed in the field of meteorology. Electronic barometers, aneroid barometers, mercury barometers are generally instruments for atmospheric pressure measurement. The barometer must be calibrated periodically to ensure the performance of the instrument. To achieve the best target uncertainty during calibration, besides using an accurate primary standard barometer, a stable pressure controller is also needed. Pressure calibration media using a pressurised test chamber is more beneficial due to its capability to accommodate all types of pressure sensors. However, pressurise test chamber still requires an operator to control and stabilise pressure inside the test chamber. In this study, fuzzy logic has been programmed into a microcontroller to control the solenoid valve and vacuum pump for regulating air pressure inside a pressurised test chamber automatically. Fuzzy logic changes the solenoid valve states periodically by varying the opening and closing times. The final result of this study is a comparison between the calibration results using pressure controller with fuzzy logic and without fuzzy logic with the same primary standard and unit under test. The result of expanded uncertainty without a fuzzy logic controller is 13.06 hectopascal. Meanwhile, the pressure calibration process using fuzzy logic to control pressure in pressurised test chamber achieve 0.09 hectopascal of expanded uncertainty in 1000 hectopascal pressure value with coverage factor, k=2, and confidence level of no less than 95 %.
Health Policy Challenge for Breast Cancer Prevention: A Case Report
Authors: Torkmandi Hojjat , Pourrahimi Akbar , Afshar Mahnaz Keshavarz , Fayazi Sanaz , Abdi Mohammad
Published: July 2021

Breast cancer early diagnosis increases treatment chances, and self-examination is one of the commonest screening methods employed by women. The case of a 24-year-old Iranian woman with a history of mild mental retardation and chest pain was reported. A large lump was detected in the breast during visitation to the surgical clinic. The parents stated the lump was  noticed due to a shape change in the clothes covering the patient's chest area. Therefore, the patient had mastectomy surgery after a biopsy and a malignant breast lump was confirmed. The registration and identification of people with mental disorder histories or various mental retardation degrees in each region's health centers to periodically assess their breast health tend to reduce the risk of late breast cancer detection in women.
Patient Perceptions Toward the Changes in Outpatient Oncology Service During the COVID-19 Pandemic
Authors: Prajoko Yan Wisnu , Supit Tommy , Azam Mahalul
Published: July 2021

COVID-19 crisis has posed an enormous challenge for all healthcare services. Therefore, this study aimed to describe the cancer patients’ knowledge and perceptions on oncology service quality during the COVID-19 pandemic. Cancer outpatient knowledge and perceptions toward the changes in chemotherapy and radiotherapy service in response to the pandemic was evaluated using a questionnaire. Majority of the 230 participants were knowledgeable about the pandemic and more than 95% of them claimed to sufficiently practice preventive measures. Television and the internet were their main source of information, and despite the fear of being infected by the COVID-19 virus, less than 15% of the respondents thought to stop or delay hospital visits. Generally, the changes in oncology service were well-received by the patients and they trust the health care workers in maintaining their safety. Also, oncology services delivery to outpatients remains consistent despite several alterations in hospital policies. Personal protective equipment utilization by health care workers and patients proved to be an important factor in reducing anxiety during hospital visits. Policy makers need to fully utilize the internet and associated mobile applications as an education tool.
Impact of stone ground ‘V-fines’ dispersion and compatibilization on polyethylene wood plastic composites
Authors: Immonen Kirsi , Saharinen Erkki , Nurminen Ilkka , Sirviö Jari , Sandquist David
Published: July 2021

Recent studies have suggested that blocky mechanical pulp fines (CTMP fines) and fibrillar fines (SMC fines) have a negative impact on biocomposite modulus of rupture (MoR) in compression molded biocomposites. In addition, it was suggested that CTMP fines also have a negative impact on biocomposite modulus of elasticity (MoE). This study investigated whether these findings transfer to other types of cellulose fines material and injection molding. The effect of ‘V-fines’ addition to sawdust- and TMP-based biocomposites was analyzed, with respect to fines concentration, dispersing agent, and compatibilizers. The results indicated that the addition of ‘V-fines’ increased the stiffness (MoE) of all the analyzed compositions, while reducing the elongation at break. The addition of ‘V-fines’ reduced the tensile and flexural strength of TMP biocomposites, while it was largely unaffected for sawdust biocomposites. Flexural strength for neat ‘V-fines’ composites showed an increase that was proportional to the remaining pulp fibers composition. The addition of a dispersant agent to the ‘V-fines’ increased tensile strength, suggesting that an increased dispersion of the ‘V-fines’ can be achieved and is beneficial to the composite. The effects of the analyzed compatibilizer (polyethyleneoxide) was negligible, except for a small indication of increased MoE for fines / sawdust biocomposites.
When one is singular: Notes on zero-person constructions in Latvian
Authors: Nau Nicole
Published: July 2021

Axel Holvoet has demonstrated that Latvian has two types of zero-person constructions which formally differ in grammatical number, and that the singular type has a parallel in Finnic, but not in Lithuanian. This paper shows that the meanings covered by the two types are distinct and do not overlap. Using the framework proposed by Gast and van der Auwera for the description of human impersonal pronouns, it is shown that the singular type is characterized by non-veridicality and an internal perspective. As in Finnish, but not Estonian, it is used in conditional sentences with all kinds of verbs. The plural type is used in Latvian as well as in Lithuanian with veridical propositions and an external perspective.
The submerged genitive in Old Prussian
Authors: Petit Daniel
Published: July 2021

This paper is devoted to the Old Prussian phrase ʃwaiāʃmu ʃupʃei buttan ‘to his own house’ (Enchiridion, III 876). Far from being simply the result of a syntactic error, the genitive ʃupʃei ‘of oneself’ can be recognized as the reflex of an archaic syntactic pattern, the “submerged genitive”, which has left numerous traces in Baltic and other Indo-European languages (Slavic, Greek, Latin, Old High German).
The origin of nasality in Macedonian dialects
Authors: Sawicka Irena
Published: July 2021

There is general consensus that the southern Macedonian dialects have partially retained the Proto-Slavic nasal vowels, and that the preservation was favoured by local Greek phonetics. There was, however, an additional source of (non-etymological) nasality in Macedonian – the Greek pre-nasalisation of stops. In the article, I would like to re-examine this issue in terms of the hypothesis that the source of nasality in Macedonian dialects was not the old nasal vowels, but the Greek pre-nasalisation of stops.
Louis Hjelmslev and the Baltic countries
Authors: Vykypěl Bohumil
Published: July 2021

This paper deals with texts by Louis Hjelmslev on Baltic topics, in particular an article from 1946 in which he defended the right of the Baltic countries to independence.
Adjacent vs. separated placement of preposition and noun as a factor in noun inflection: The cases of Bosnian- Croatian-Serbian pazuho ‘armpit’
Authors: Browne Wayles
Published: July 2021

The alternations k~c, g~z, and x~s occurring before i in Bosnian-Croatian-Serbian (BCS) noun declension stem from the Second Palatalization of Velars, but are no longer phonologically conditioned. In the dative-locative singular of nouns with nominative in -a, they are favored or hindered by a combination of morphological criteria. In the dative-instrumental-locative plural of masculine nouns, they are almost exceptionless. In the same three cases of neuter nouns they occur more when the noun is directly after a preposition, less when other words intervene between the preposition and the noun, a phenomenon that has not previously been remarked in the literature. We exemplify it with the noun pazuho ‘armpit’.
Latvian verbs in -ēt: semantics vs. conjugation
Authors: Дубасова Анжелика
Published: July 2021

The conjugation of secondary Latvian verbs is determined with high accuracy by their suffixes. However, verbs with the suffix -ē- are different: they are more or less equally divided between the traditional second and third conjugations. The article sets out to prove or disprove the hypothesis that the assignment of Latvian verbs with the suffix -ē- to a specific conjugation correlates with their semantics. For that purpose, 705 disyllabic verbs ending in -ēt were collected and marked by their origin, transitivity, and conjugation. Verbs that are not obvious borrowings were then divided into semantic classes. As a result of the semantic classification, the working hypothesis was confirmed: second conjugation verbs ending in -ēt predominantly denote agentive actions (creation, destruction, modification, etc.), whereas third conjugation verbs usually denote phenomena, processes, states, and sound production. The results suggest that the Latvian verbal system exhibits a close interrelation between semantics and morphology.
Apelando a la conciliación nacional: los comicios de 1904 para Concejo de Bogotá
Authors: Suárez Mayorga Adriana María
Published: July 2021

La nueva sociología urbana no solo ha hecho hincapié en la necesidad de considerar la interpretación histórica como un componente indispensable en el análisis de cualquier sociedad, sino que además ha reivindicado la importancia de la política para comprender la producción tanto física como social del espacio urbano. La traducción de estos preceptos al ámbito de los estudios centrados en la esfera local implica asumir que la facultad que poseen las ciudades para escoger, por medio de la representación popular, a sus dignatarios, es un factor determinante para que la administración municipal adquiera un lugar preeminente en el andamiaje institucional propio del nivel nacional.Teniendo en cuenta lo anterior, este artículo tiene como objetivo examinar los comicios para concejales realizados en Bogotá en 1904, con el fin de dilucidar de qué manera los problemas urbanísticos exteriorizados por la urbe se convirtieron en una suerte de caballo de batalla que los publicistas utilizaron, o bien para aconsejar a los ciudadanos sobre la elección que iban a realizar, o bien para denunciar la crisis que vivía el territorio colombiano.Metodológicamente, la argumentación se cimentará en un examen riguroso de fuentes primarias y secundarias, otorgando especial relevancia a la prensa de la época. La conclusión principal del escrito es que la preocupación por el desarrollo bogotano evidenciada en los periódicos de comienzos del siglo XX no debe entenderse como un mero elemento discursivo sino como una crítica mordaz al férreo centralismo político y administrativo impuesto durante la Regeneración (1886-1910).
Invitaciones por parte del espacio público para el Parque Sendero en Tauramena (Casanare, Colombia)
Authors: Alarcon Martinez Julian Andres
Published: July 2021

El sistema de espacio público del suelo urbano del municipio de Tauramena está conformado por catorce parques recreacionales, el centro polifuncional y varias zonas verdes. El Parque Sendero es el de mayor extensión y, por su escala e impacto, surgió la necesidad de diagnosticar las dinámicas urbanas alrededor de este debido a la aparente desarticulación con su contexto, lo cual desestimula el desarrollo de actividades culturales, deportivas y de ocio. El presente artículo tiene como objetivo plantear bases conceptuales para proyectar espacios urbanos adecuados y una renovación del Parque Sendero del municipio de Tauramena, a partir del estudio de sus interacciones en el contexto, y por medio de una serie de invitaciones desde los enfoques de la identidad, lo físico y lo simbólico. La información se recopiló de forma cualitativa, así como los resultados de las entrevistas y el análisis respectivo; se señala la manera como se desconoce al peatón en el Parque y se dan algunos conceptos que permitirán cambiar este panorama.
Self- and Peer-Assessment of Student-Generated Podcasts to Improve Comprehensibility in Undergraduate EFL Students
Authors: Cadena-Aguilar Albedro , Álvarez-Ayure Claudia Patricia
Published: July 2021

This study reports on a mixed-methods research project into self- and peer-formative assessment of student-generated podcasts in a group of 18 undergraduate students. The aim was to determine whether there were any gains in the spoken comprehensibility of the participants while having them reflect on and adjust their use of suprasegmentals (thought groups, sentence stress, and intonation). Data were gathered from student logs, student-generated podcasts, and a questionnaire. Results unveiled the exhibition of self-regulated behaviours and gains in comprehensibility. This study highlights the importance of helping learners look critically and reflectively at their own oral production and of incorporating training on suprasegmentals within English as a foreign language courses to help learners communicate more effectively within a globalised context.
Approaching Teaching as a Complex Emotional Experience: The Teacher Professional Development Stages Revisited
Authors: Villegas-Torres Perla , Lengeling M. Martha
Published: July 2021

Along the evolving teaching journey, teachers experience a series of events that allow them to transition from novice to expert. Throughout the years, such transition has been the object of theories and debates about how this process is carried out, and when it is that teachers move from one stage to the other. This article presents a study of a Mexican teacher of English and examines the professional-developmental stages based on Huberman’s (1993) career cycle model. Its aim is to understand the challenges and decisions a teacher may encounter in her or his career. The article shows the realities a teacher faces by exploring the concepts of emotions, identity, socialization, and agency. Moreover, it questions the belief that teachers achieve expertise through accumulating years of practice.
Expressive Writing to Relieve Academic Stress at University Level
Authors: Argudo Juanita
Published: July 2021

This paper reports on a descriptive mixed-method study that aimed to identify the impact of expressive writing on relieving the academic stress of 157 undergraduate students at an Ecuadorian university. Data were gathered through two questionnaires and from focus groups. Results showed enduring relief of academic stress. Furthermore, they help to shed light on the need to study the impact of academic stress on university students and to look for different strategies that can alleviate it. These findings could help to understand students’ needs, as they have essential implications in teachers’ practices and, consequently, in students’ performance. In conclusion, expressive writing has a positive effect on helping to ease academic stress and overcome some difficulties caused by this issue.
Fostering Citizenship and English Language Competences in Teenagers Through Task-Based Instruction
Authors: Romero Yanilis , Pérez Adriana
Published: July 2021

This research analyzes how citizenship and communicative competences can be fostered through a task-based approach to language teaching. This paper proposes the design of a unit with social components as the main meaningful task for the teaching of the English language and for fostering citizenship competencies in A2 level learners. An action research method was used; data collection techniques included observations, diaries, interviews, and students’ artifacts. Findings report that tasks might foster English language use if those are designed by taking into account students’ context and interests. Furthermore, real-life tasks derived from contextual features can enhance civic engagement and promote values, which can be signals of citizenship.
Dois caminhos para aproximar a universidade da escola: a equipe de supervisores de estágio e a formação continuada
Authors: Carlier Ghislain , Clerx Marie
Published: July 2021

Resumo A universidade consegue manter relações de confiança com os professores que ela formou? Os pesquisadores denunciam regularmente as diferenças que separam a formação inicial e o ensino no meio escolar, em razão da falta de (re)conhecimento e de interesse mútuos. Ao contrário, este artigo analisa duas experiências positivas. A primeira delas revela o funcionamento de uma equipe de orientadores que acompanham os pares estagiários-supervisores de estágio, com ênfase na transmissão da paixão e no compartilhamento do prazer de ensinar e de aprender. A segunda, por sua vez, estuda a construção de uma relação positiva entre uma pesquisadora e os colegas envolvidos em uma pesquisa participativa. Esta última estuda a sensibilidade desses colegas durante o reinvestimento, em suas aulas, dos conhecimentos adquiridos em uma formação continuada ocorrida na universidade. Os resultados mostram a gratidão desses colegas em relação a essa pesquisadora quando ela constrói seu mapa de identidade profissional, decodifica seu aprendizado em condições reais de trabalho e valoriza suas artes do fazer.