bluuebunny/crossref_metadata_2025 huggingface dataset:
CFIR simplified: Pragmatic application of and adaptations to the Consolidated Framework for Implementation Research (CFIR) for evaluation of a patient‐centered care transformation within a learning health system
Authors: Safaeinili Nadia , Brown‐Johnson Cati , Shaw Jonathan G. , Mahoney Megan , Winget Marcy
Published: September 2019

Introduction

The Consolidated Framework for Implementation Research (CFIR) is a commonly used implementation science framework to facilitate design, evaluation, and implementation of evidence‐based interventions. Its comprehensiveness is an asset for considering facilitators and barriers to implementation and also makes the framework cumbersome to use. We describe adaptations we made to CFIR to simplify its pragmatic application, for use in a learning health system context, in the evaluation of a complex patient‐centered care transformation.

Methods

We conducted a qualitative study and structured our evaluation questions, data collection methods, analysis, and reporting around CFIR. We collected qualitative data via semi‐structured interviews and observations with key stakeholders throughout. We identified and documented adaptations to CFIR throughout the evaluation process.

Results

We analyzed semi‐structured interviews with key stakeholders (n = 23) from clinical observations (n = 5). We made three key adaptations to CFIR: (a) promoted “patient needs and resources,” a subconstruct of the outer setting, to its own domain within CFIR during data analysis; (b) divided the “inner setting” domain into three layers that account for the hierarchy of health care systems (i. pilot clinic, ii. peer clinics, and iii. overarching health care system); and (c) tailored several construct definitions to fit a patient‐centered, primary care setting. Analysis yielded qualitative findings concentrated in the CFIR domains “intervention characteristics” and “outer setting,” with a robust number of findings in the new domain “patient needs and resources.”

Conclusions

To make CFIR more accessible and relevant for wider use in the context of patient‐centered care transformations within a learning health system, a few adaptations are key. Specifically, we found success by teasing apart interactions across the inner layers of a health system, tailoring construct definitions, and placing additional focus on patient needs.
Exploring the Basic Concepts of HDR: Dynamic Range, Gamma Curves, and Wide Color Gamut
Authors: Sharma Abhay
Published: September 2019

High dynamic range (HDR) offers a wealth of opportunities, in terms of immersion and innovation in storytelling and special effects. But what does it entail, exactly? Here, in the second of a two‐part series, we consider the concepts, tools, and specifications that are (and are not yet) in place to generate and broadcast visually compelling HDR content.
Implementation and evaluation of a primary diabetes prevention programme for young adult employees in Japan: A non‐randomized controlled trial
Authors: Nagamine Hitomi , Lyu Xiaowei , Maruyama Kayo , Morita Kumiko
Published: September 2019

Aim

To determine the effects of a primary diabetes prevention programme created for healthy young adults.

Design

This study was a non‐randomized controlled trial.

Methods

The participants were 20–39‐year‐old employees of two automobile sales companies. The intervention group (N = 154) received six original educational brochures and films created specifically for young adults, while the control group (N = 157) received none. Data were collected pre‐intervention and immediately after and 10 weeks after intervention. Change in knowledge about diabetes, its prevention and health management were measured.

Results

Overall, 129 interventions and 141 controls completed the trial. In items related to diabetes prevention, the intervention group increased their knowledge relative to controls (all p < .05). Awareness of susceptibility to diabetes also increased more in the interventions (p = .029). The interventions also improved more with items related to dietary behaviour (p < .05). This trial has been registered with UMIN‐CTR clinical trial (UMIN000023749).
Teaching accelerated nursing students’ self‐care: A pilot project
Authors: Green Cheryl
Published: September 2019

Aim

A benchmark of 4 has been determined for the reduction of self‐reported stress by nursing students’ status post 5 weeks of holistic educational activities and interventions provided by a nurse educator.

Design

Provision 5 in the American Nurses Association Code of Ethics for Nurses with Interpretive Statements emphasizes the duty of the nurse to not only promote the health and safety of others, but to self as well (ANA, 2015, Code of ethics with interpretive statements, Nursebooks.org). A self‐care for nurses’ pilot project was trialled with 25 accelerated nursing students over the course of 5 weeks. Holistic education programmes were facilitated by a nurse educator uninvolved in providing clinical or classroom education to the students.

Methods

The Standards for Quality Improvement Reporting Excellence (SQUIRE) guidelines are used in this pilot project as a framework to explore standardization of education of nursing students about self‐care in nursing programmes and to promote positive health behaviours and student nurses’ insight into how nurses’ self‐care can have an impact on patient outcomes. The self‐care pilot project introduced the importance of self‐care for the pre‐licensure nursing student by teaching healthy eating, physical exercise, the value of sleep, use of positive affirmations and aromatherapy to a cohort of accelerated nursing students over the course of 5 weeks. The Star Model of Knowledge Transformation was the theoretical framework for the pilot study. Two questionnaires were used by the principal investigator to obtain participant data, the Project Participant Questionnaire and the Final‐Year Group Questionnaire.

Results

On completion of the self‐care for nurses’ pilot, the nursing students reported a reduction in stress and an increased ability to cope with stress after exposure to different holistic stress reduction strategies. An average benchmark of 4.36 was achieved indicating that the nursing students’ self‐care had improved status post the interactive teaching intervention.

Self‐care taught to pre‐licensure nursing students by nurse educators can enhance their self‐awareness of the importance of stress reduction and care of themselves while enduring the academic rigour and simultaneous clinical practicum experiences in nursing programmes.

Applying self‐care behaviours to reduction of stress for nursing students may be of benefit to of students as they transition from the pre‐licensure to graduate nurse roles. Hence, teaching health behaviours that are self‐protective and contribute to maintaining safe clinical environments for nurses and the patients in their care.
Where's the Spam? Interest Groups and Mass Comment Campaigns in Agency Rulemaking
Authors: Balla Steven J. , Beck Alexander R. , Cubbison William C. , Prasad Aryamala
Published: September 2019

This article examines the sponsorship and content of mass comment campaigns in administrative rulemaking in the United States. Mass comment campaigns consist of identical and near‐duplicate comments sponsored by organizations and submitted by group members and supporters to government agencies in response to proposed rules. Drawing from research on interest group lobbying, it is posited that organizations of all types sponsor mass comment campaigns, but that campaigns submitted by regulated entities (i.e., industries) are more substantive than campaigns generated by beneficiaries of stringent regulations (e.g., environmental advocacy groups). These expectations are confirmed in the context of more than one thousand mass comment campaigns that occurred during Environmental Protection Agency rulemakings between 2012 and 2016. The analysis primarily focuses on data collected about the identity of organizations that sponsor mass comment campaigns and the content (i.e., length and complexity) of campaigns, and is supplemented by interviews conducted with organizations that sponsor campaigns. The findings suggest that mass comment campaigns are not a phenomenon meriting unique explanation, but rather occur in a manner similar to lobbying in other policymaking venues, such as lawmaking in Congress.
Biocompatible Lipid‐Coated Persistent Luminescent Nanoparticles for In Vivo Imaging of Dendritic Cell Migration
Authors: Harizaj Aranit , De Clercq Olivier Q. , Descamps Benedicte , Vanhove Christian , De Smedt Stefaan C. , Poelman Dirk , Lentacker Ine , Braeckmans Kevin
Published: September 2019

Dendritic cell (DC)‐based vaccines for immunotherapy have already achieved promising results in the last decade. To further improve current treatment protocols and enhance the therapeutic outcome, noninvasive in vivo tracking of DCs remains of crucial importance. Persistent luminescent nanoparticles (PLNPs) are inorganic materials which show an afterglow for hours after the optical excitation has ceased. If the afterglow is in the near‐infrared, the emission of injected particles can be tracked in vivo. However, stability and toxicity issues limit the use of bare PLNPs for biological applications. Therefore, appropriate surface functionalization is needed to improve their biocompatibility. In this study, it is demonstrated that near‐infrared light emitting LiGa5O8:Cr3+ nanoparticles can be functionalized with a biocompatible lipid coating which provides them with outstanding stability in biological media. In vitro experiments show efficient uptake, absence of cytotoxicity even at very high particle concentrations, and no adverse effects on the maturation potential of DCs. DCs labeled with lipid‐coated LiGa5O8:Cr3+ nanoparticles injected in mice can be imaged over days, confirming efficient in vivo migration to the popliteal lymph node. Together the results show that lipid coated LiGa5O8:Cr3+ nanoparticles possess excellent possibilities for further use in research and development of DC based vaccines.
Analysis of dynamic characteristics of viscoelastic frame structures
Authors: Lewandowski Roman , Wielentejczyk Przemysław
Published: September 2019

Planar frame structures made of a viscoelastic material are considered in the paper. The technically very important structures made of a homogenous material are contemplated. A family of rheological models (classic and fractional) are used to describe the mechanical properties of the viscoelastic material. In particular, the dynamic characteristics of the structures are of interest. A numerically very efficient method is proposed to determine such characteristics. The method requires the solution to the linear eigenvalue problem for corresponding elastic structures and the solution to a nonlinear, algebraic equation. The presented method is much more efficient than other methods where, very often, the continuation method is used to solve the nonlinear eigenvalue problem. The influence of temperature changes on dynamic characteristics is analyzed using the frequency–temperature principle. The results of several parametric analyses are presented and discussed. For the first time, the influence of temperature on the dynamic characteristics of beams has been studied in detail.
Professional burnout and its correlates in Polish donor transplant coordinators
Authors: Bury Marcin , Rozenek Hanna , Kamiński Artur , Czerwiński Jarosław , Wójtowicz Stanisław , Banasiewicz Jolanta , Owczarek Krzysztof
Published: September 2019

Job demands-resources (JD-R) model of professional burnout states that job demands predict the feeling of exhaustion, and lack of job resources—disengagement from work. This research project investigated professional burnout and it correlates, including sex, death anxiety, and relationship status in 108 Polish donor transplant coordinators involved in organ, tissue, and cell transplantations. This study employed the Polish version of the Oldenburg Burnout Inventory which follows the JD-R model, the Psychosocial Working Conditions Questionnaire—a Polish instrument based on the model of job stress proposed by Karasek—and the Polish version of the Fear of Death and Dying Questionnaire. The results were suggestive of average levels of job stress and burnout in the studied population, with men being more disengaged than women. Participants who were in relationship had significantly higher levels of exhaustion than those who were single. Exhaustion was positively correlated with years of working as a transplant coordinator but not with participants’ age. Multiple negative correlations were detected between exhaustion/disengagement and different aspects of job control, social support, and well-being. Moreover, positive correlations between different components of fear of death and dying and exhaustion were detected. Our findings, linking fear of death and dying with some aspects of professional burnout in transplant coordinators, suggest that a pre-employment screening for the level of death anxiety in candidates for transplant coordinators could be useful as this job provides chronic exposure to mortality cues.
The effect of the dispersion of microfibrillated cellulose on the mechanical properties of melt-compounded polypropylene–polyethylene copolymer
Authors: Palange Caterina , Johns Marcus A. , Scurr David J. , Phipps Jonathan S. , Eichhorn Stephen J.
Published: September 2019

Microfibrillated cellulose (MFC) is a highly expanded, high surface area networked form of cellulose-based reinforcement. Due to the poor compatibility of cellulose with most common apolar thermoplastic matrices, the production of cellulose-reinforced composites in industry is currently limited to polar materials. In this study, a facile water-based chemistry, based on the reaction of MFC with tannic acid and subsequent functionalisation with an alkyl amine, is used to render the surface of the MFC fibrils hydrophobic and enhance the dispersion of the cellulose-based filler into an apolar thermoplastic matrix. The level of dispersion of the compatibilized MFC reinforced composites was evaluated using Time of Flight Secondary Ion Mass Spectrometry and multi-channel Spectral Confocal Laser Scanning Microscopy. The agglomeration of cellulosic filler within the composites was reduced by functionalising the surface of the MFC fibrils with tannic acid and octadecylamine. The resulting composites exhibited an increase in modulus at a high cellulose content. Despite the dispersion of a large portion of the functionalised filler, the presence of some remaining aggregates affected the impact properties of the composites produced.
The influence of Li on the thermophysical properties of liquid Ga–Sn–Zn eutectic alloys
Authors: Dobosz A. , Plevachuk Yu. , Sklyarchuk V. , Sokoliuk B. , Gancarz T.
Published: September 2019

The Ga–Li system is very attractive for the development of microelectronic and Li-ion cell applications as negative electrodes. In this study, thermophysical properties such as density, surface tension, viscosity, thermal and electrical conductivity, and thermoelectric power were investigated. Taking into account the intermetallic compounds occurring in Ga–Li, the measurements were conducted in a temperature range of 323–773 K. The experimentally obtained results revealed lower density and surface tension with increasing Li additions. The viscosity, electrical conductivity and thermoelectric power slightly reduced with the addition of Li content to eutectic Ga–Sn–Zn. The opposite was true of thermal conductivity, which increased slightly. The performed Nusselt number and Peclet number calculations for eutectic Ga–Sn–Zn with Li additions show similar dependency as found in literature data for Ga and Ga–In alloys.
Personality and Psychopathology in Adults with Noonan Syndrome
Authors: Roelofs Renée L. , Wingbermühle Ellen , van der Heijden Paul T. , Jonkers Rosella , de Haan Marieke , Kessels Roy P. C. , Egger Jos I. M.
Published: September 2019

This is the first controlled study regarding personality and psychopathology in adults with Noonan syndrome (NS). Anxiety, depression, alexithymia and symptoms of Attention Deficit-Hyperactivity Disorder and Autism Spectrum Disorder, have been previously described in NS. More information regarding personality and psychopathology in NS could improve mental health care for this population. Therefore, scores on the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF), a widely used self-report questionnaire of personality and psychopathology, were compared between patients with NS (n = 18) and matched, healthy controls (n = 18). Furthermore, correlations between MMPI-2-RF scores and alexithymia, measured by the Toronto Alexithymia Scale-20, were investigated. Patients with NS showed significantly higher scores, with medium effect sizes, on MMPI-2-RF scales reflecting infrequent responses (F-r), somatic and cognitive complaints (FBS-r and RBS-r), internalizing problems (EID), demoralization (RCd) and introversion (INTR-r), although the overall profile in both groups was within the non-clinical range. Alexithymia correlated with internalizing problems and negative emotionality in the patient group. In conclusion, patients with NS showed higher levels of introversion, which may predispose them to internalizing problems. These problems were indeed more frequent in patients with NS, especially higher levels of demoralization. Patients may benefit from psychological interventions aimed to decrease internalizing problems, introversion and alexithymia.
Web-Based Intervention and Email-Counseling for Problem Gamblers: Results of a Randomized Controlled Trial
Authors: Jonas Benjamin , Leuschner Fabian , Eiling Anna , Schoelen Christine , Soellner Renate , Tossmann Peter
Published: September 2019

Web-based interventions have the potential to reduce the treatment gap for problem gambling. In the past years, several web-based help options were made available to the public. However, only few studies were conducted to test their effects. This study investigated the efficacy of two interventions for problem gamblers provided online by the German Federal Center for Health Education (BZgA). The first intervention is the guided program “Check Out” (CO), the second is email counselling (EC). A web-based randomized controlled trial with follow-up surveys after 3, 6 and 12 months was conducted. Participants were allocated to CO, to EC or to a waitlist (WL). Outcomes were the degree of problem gambling according to the Problem Gambling Severity Index, the number of days gambled in past 30 days, the highest stake during the past 30 days and the subjective well-being (WHO-5). 167 individuals were included in the trial. In comparison to the WL at the 3 months follow-up, participants of CO showed significant improvements with moderate to strong effect sizes in all outcomes. Strongest effects were found in the problem gambling severity (d = 0.91; p = 0.023), followed by the well-being (d = 0.70; p = 0.011), the gambling days (d = 0.59; p = 0.001) and the highest stake (d = 0.55; p = 0.012). Improvements were sustained until last follow-up. Compared to the WL, users of EC had beneficiary results in the problem gambling severity (d = 0.74; p = 0.022). No significant effect differences were found between CO and EC. However, according to process evaluation, users of CO reported a significantly stronger working alliance than users of EC (d = 0.70; p = 0.019) and used the intervention considerably longer (d = 0.84; p = 0.004). CO helps treatment-seeking individuals to sustainably reduce their gambling behavior and to increase their general well-being. Compared to EC, CO seems a better support option, since its effects include a wider range of outcomes. Possible reasons are the more engaging program structure and elements of CO, as well as the closer interaction between client and counselor.
The transport and mass balance of fallout radionuclides in Brotherswater, Cumbria (UK)
Authors: Appleby P. G. , Semertzidou P. , Piliposian G. T. , Chiverrell R. C. , Schillereff D. N. , Warburton J.
Published: September 2019

This paper investigates the role of intervening transport processes on lake sediment records of the atmospherically deposited radionuclides 210Pb and 137Cs. Brotherswater is of particular interest to this issue in that its large catchment/lake area ratio and short water residence time are likely to amplify the influence of these processes, both from the catchment and through the water column. Brotherswater is also unique in being the site of two earlier multicore studies that, together with the present study, span a period of 4 decades. Measurements of fallout radionuclides were made on soil cores, suspended sediments and sediment cores, and the results combined with those from earlier studies to construct mass balances for 210Pb and 137Cs in Brotherswater. The results showed that catchment inputs accounted for 63% of 210Pb entering the lake. Further, just 47% of 210Pb entering the water column was delivered to the sediment record. For comparison, in an earlier study at nearby Blelham Tarn with a relatively smaller catchment but longer water residence time it was shown that 47% of 210Pb inputs were delivered via the catchment, 75% of which were delivered to the sediment record. Results from both sites suggest that 210Pb is predominantly transported on fine particulates with a mean particle size of 3–4 μm. Their relatively slow removal from the water column allows them to be transported relatively uniformly throughout the lake and may help account for the fact that simple 210Pb dating models are relatively reliable in spite of the complexities of the transport processes. Mass balance calculations for 137Cs are more complicated because of the variable fallout record. Measurements of 137Cs in the input stream and water column showed that catchment inputs are still significant 30 years after the last significant fallout (Chernobyl). Modelled results showed that catchment inputs delayed the date of peak inputs of weapons test fallout to the lake though by no more than 2 years. Although the results presented here are primarily concerned with fallout radionuclides and their reliability for dating, they also have implications for the use of sediment archives in reconstructing historical records of other atmospherically deposited substances such as trace metals or persistent organic pollutants.
The generalized Weyl Poisson algebras and their Poisson simplicity criterion
Authors: Bavula V. V.
Published: September 2019

A new large class of Poisson algebras, the class of generalized Weyl Poisson algebras, is introduced. It can be seen as Poisson algebra analogue of generalized Weyl algebras or as giving a Poisson structure to (certain) generalized Weyl algebras. A Poisson simplicity criterion is given for generalized Weyl Poisson algebras, and an explicit description of the Poisson centre is obtained. Many examples are considered (e.g. the classical polynomial Poisson algebra in 2n variables is a generalized Weyl Poisson algebra).
Fractal characteristics and significances of the nanopores in oil shales during hydrous pyrolysis
Authors: Sun Lina , Fu Deliang , Chai Shunqi , Yang Wenxia , Zhou Kai , Li Wei
Published: September 2019

In order to explore the pore characterizations in shales during organic matter evolution, a series of simulation experiments were conducted. The artificial hydrous pyrolysis was conducted on the same seven columned oil-shale samples at 250 °C, 300 °C, 350 °C, 375 °C, 400 °C, 450 °C and 500 °C, respectively. To obtain the characteristics of pore structures in shales, the unheated and the residual solid samples were analyzed by low-pressure nitrogen adsorption method. Based on the nitrogen adsorption isotherms, fractal dimensions were calculated by the model of Frenkel–Halsey–Hill, which also contained the fractal dimension of D1 and D2 before and after the relative pressure P/Po = 0.5, respectively. And then the relationships of simulation temperatures (thermal maturity), total-, macro-, meso- and micro-pores volumes, specific surface areas and diameters to fractal dimensions were investigated. The results showed that the average value of D2 (2.6110) was higher than D1 (2.4147) and there was a positive relationship between them (R2 = 0.9237), which indicated that though D2 and D1 were more related to pore structures and surfaces, the better linear relationships suggested that both of them could be used in the representation of pore structures and surfaces in shales. With the thermal maturity increasing, the obvious fractal characteristics were, the complexity of pore structures were, which may be associated with the following cause-and-effect relationships. During the pyrolysis, the generation of hydrocarbons increased, as well as the consumption of TOC may increase the volume and surface area of total-, macro-, meso- and micro-pores but decrease the corresponding average diameter and then the quantities of smaller pores occurred and led to the strengthening of pore heterogeneity in shales. Based on the fractal characteristics, we also found the higher thermal maturity would result in the better connections among pores but worse permeability in shale, which further increased the gas adsorption quantity. Therefore, analyzing the fractal characteristics in shales could provide help for clarifying the characteristics of reservoirs as well as the comprehensive exploration and development of shale gas.
Tilting modules and exceptional sequences for leaf quotients of type A zig-zag algebras
Authors: Persson Westin Elin
Published: September 2019

We classify generalized tilting modules and full exceptional sequences for the family of quasi-hereditary quotients of type A zig-zag algebras and for a related family of algebras. We also give a characterization of these quotients as quasi-hereditary algebras with simple preserving duality that are “close” to self-injective algebras.
Programmed death ligand‐1/programmed death‐1 inhibition therapy and programmed death ligand‐1 expression in urothelial bladder carcinoma
Authors: Yu Wei‐Bo , Rao Jian‐Yu
Published: September 2019

After two decades of unchanged paradigms, the treatment strategies for advanced urothelial bladder cancer have been revolutionized by emerging programmed death ligand‐1 (PD‐L1)/programmed death‐1 (PD1) inhibition therapy. Increased evidence is demonstrating the efficacy of PD‐L1/PD1 inhibition therapy in both second‐line and first‐line settings. However, the percentage of patients who benefit from anti‐PD‐L1/anti‐PD1 therapy is still low. Many questions have been raised in the development of biomarker‐driven approaches for disease classification and patient selection. In this perspective, we discuss PD‐L1/PD1 expression in urothelial bladder carcinoma, review approved anti‐PD‐L1/anti‐PD1 agents for bladder cancer treatment and current ongoing studies investigating combination treatment strategies, and explore PD‐L1 expression status for the evaluation of bladder cancer immunotherapy.
Variable rotor speed strategy for coaxial compound helicopters with lift–offset rotors
Authors: Yuan Y. , Thomson D. , Chen R.
Published: September 2019

The coaxial compound helicopter with lift-offset rotors has been proposed as a concept for future high-performance rotorcraft. This helicopter usually utilizes a variable-speed rotor system to improve the high-speed performance and the cruise efficiency. A flight dynamics model of this helicopter associated with rotor speed governor/engine model is used in this article to investigate the effect of the rotor speed change and to study the variable rotor speed strategy. Firstly, the power-required results at various rotor rotational speeds are calculated. This comparison indicates that choice of rotor speed can reduce the power consumption, and the rotor speed has to be reduced in high-speed flight due to the compressibility effects at the blade tip region. Furthermore, the rotor speed strategy in trim is obtained by optimizing the power required. It is demonstrated that the variable rotor speed successfully improves the performance across the flight range, but especially in the mid-speed range, where the rotor speed strategy can reduce the overall power consumption by around 15%. To investigate the impact of the rotor speed strategy on the flight dynamics properties, the trim characteristics, the bandwidth and phase delay, and eigenvalues are investigated. It is shown that the reduction of the rotor speed alters the flight dynamics characteristics as it affects the stability, damping, and control power provided by the coaxial rotor. However, the handling qualities requirements are still satisfied with different rotor speed strategies. Finally, a rotor speed strategy associated with the collective pitch is designed for maneuvering flight considering the normal load factor. Inverse simulation is used to investigate this strategy on maneuverability in the Push-up & Pull-over Mission-Task-Element (MTE). It is shown that the helicopter can achieve Level 1 ratings with this rotor speed strategy. In addition, the rotor speed strategy could further reduce the power consumption and pilot workload during the maneuver.
Hegel's Reception of Aristotle's Theology
Authors: Dangel Tobias
Published: September 2019

In several of his writings Hegel suggests an identification of his absolute idea/spirit with Aristotle's God in theMetaphysics. This suggestion is remarkable since it indicates that Hegel regarded his philosophy in line with classical positions in ancient metaphysics. Although there is increasing discussion of the relation between Hegel and Aristotle it is still doubtful what it was that Hegel seemed to find at the highest point of Aristotle's philosophy. To clarify this relation within the realm of first philosophy I will first give a short reconstruction of Aristotle's conception of God in order, second, to confront this conception with the absolute idea/spirit in Hegel. Against Ferrarin, I will not primarily discuss the conception of actuality/activity and infinite subjectivity; rather I will focus on Aristotle's and Hegel's ontological understanding of truth. The new thesis in my paper is that Hegel can relate his theory of the absolute idea/spirit to Aristotle's God on the basis of their shared understanding of truth. This understanding allows both of them to find the highest realization and thus the fulfillment of truth in the self-thinking thinking of God (Aristotle) or the self-thinking thinking of the absolute idea/spirit (Hegel). When Hegel seems to return to Aristotle at the end of his system, this return has its systematic link in the idea of a fulfilled truth which is God or the Absolute in the sense of self-thinking thinking. Although Hegel's return to Aristotle's theology has a certain plausibility, it is also limited by the fact that for Aristotle God's self-thinking thinking is not a process of self-determination, as Hegel finds it to be and which leads him to miss a crucial feature of Aristotle's theology.
Errors in antibiotic transitions between hospital and nursing home: How often do they occur?
Authors: Dickinson Drew T. , Rashid Syma , Weiland Anastasiia , Tjoa Thomas , Kim Diane S. , Huang Susan S.
Published: September 2019

We performed systematic review on 40 paired hospital and nursing home charts from a clinical trial to evaluate the fidelity of transitions of care among those discharged on antibiotics. We found that 30% of transitions included an inappropriate change to the patient’s antibiotic plan of care.
Molecular and morphometric identification of pistachio psyllids with niche modeling ofAgonoscena pistaciae(Hemiptera: Aphalaridae)
Authors: Lashkari Mohammadreza , Burckhardt Daniel , Shamsi Gushki Roghayeh
Published: September 2019

Species ofAgonoscena(Hemiptera: Aphalaridae) are key pests of pistachio in all of the most important pistachio producing countries in the Old World. The efficiency and accuracy of DNA barcoding for the identification ofAgonoscenaspecies were tested using mitochondrial cytochrome c oxidase subunit 1 (mtCO1) and cytochrome b (cytb) gene sequences. Moreover, morphometric sexual dimorphism was studied. Finally, the potential geographical distribution ofAgonoscena pistaciae, the most important pistachio pest, was calculated using the MaxEnt model. Similar relationships of clustering were found in the morphometric analysis and the molecular analyses withmtCO1andcytbgenes, withA. bimaculataandA. pistaciaebeing closely related, andA. peganiconstituting their sister group. Although the results showed that thecytbgene is a better marker for barcoding in this group, themtCO1gene clearly separates the three psyllid species makingmtCO1suitable for diagnostic purposes. A geometric morphometric analysis showed that the distance between landmark number 7 (bifurcation of vein M) to the fore margin of the forewing, and the distance between landmarks number 6 (apex of vein Cu1b) and 11 (wing base), are the most important geometric characters for diagnosing the studied species. Moreover, the forewing shape of males vs females is similar inA. pistaciaeandA. bimaculatabut differs significantly inA. pegani. In the ecological niche modeling of the distribution ofA. pistaciae, the most important contribution was made by the variable ‘minimum temperature of coldest period’. The most suitable areas forA. pistaciaeare restricted to Eastern, Southern and some parts of Central Iran.
Seed classification of three species of amaranth (Amaranthus spp.) using artificial neural network and canonical discriminant analysis
Authors: Bagheri A. , Eghbali L. , Sadrabadi Haghighi R.
Published: September 2019

The current study was conducted in 2013 to identify the seeds of three species of Amaranthus, Amaranthus viridis L., Amaranthus retroflexus L. and Amaranthus albus L., by using the artificial neural network (ANN) and canonical discriminant analysis (CDA) methods. To begin with, photographs were taken of the seeds and 13 morphological characteristics of each seed extracted as predictor variables. Backward regression was used to find the most influential variables and seven variables were derived. Thus, predictor variables were divided into two sets of 13 and seven morphological characteristics. The results showed that the recognition accuracy of the ANN made using 13 and seven predictor variables was 81.1 and 80.3%, respectively. Meanwhile, recognition accuracy of the CDA using the seven and 13 predictor variables was 74.0 and 75.7%, respectively. Therefore, in comparison to CDA, ANN showed higher identification accuracy; however, the difference was not statistically significant. Identification accuracy for A. retroflexus was higher using the CDA method than ANN, while the ANN method had higher recognition accuracy for A. viridis than CDA. In addition, use of 13 predictor variables yielded a greater identification accuracy than seven. The results of the current study showed that using seed morphological characteristics extracted by computer vision could be effective for reliable identification of the similar seeds of Amaranthus species.
Adapting the Portuguese dignity question framework for adolescents: ages 10–18
Authors: Julião Miguel , Antunes Bárbara , Santos Ana , Sobral Maria Ana , Albuquerque Sara , Fareleira Filipa , Runa Daniela , Faria de Sousa Paulo , Chaves Petra , Gonçalves Célia , Soares Duarte , Chochinov Harvey Max
Published: September 2019

Objective

Dignity therapy (DT) is well established in adult populations, and it is likely that it could benefit younger people. This study aimed to adapt the adult Portuguese DT question framework for adolescents (DT-QF-Adol) (ages 10–18).

Method

Five stages were followed: (1) the Portuguese DT-QF for adults was adapted for adolescents with the original author's collaboration, (2) an expert committee provided feedback on the adapted version, (3) an initial consensus version of the DT-QF-Adol was created, (4) expert committee consult affirmed final consensus, and (5) validation stage with a sample of 17 adolescents followed in ambulatory psychology clinic.

Results

DT's original author endorsed the final Portuguese DT-QF-Adol, reinforcing that it captures the fundamental dimensions of DT. There was 100% agreement on the final consensus version and defined age group (10–18 years old). Twenty adolescents were invited to participate, and 17 were included after informed consent was obtained; 53% were female. The average age was 12.7 years. The interviewed adolescents reported that the DT-QF-Adol was clear, and they did not identify any ambiguity or difficulty in answering any of the questions. They assumed that this information could positively affect the way parents and friends see and cared for them, permitting others to understand their concerns and preferences. Participants felt that the DT-QF-Adol could be a good starting point for a conversation with their loved ones. Although they did not consider vital for health professionals to access their answers, they strongly felt that the DT-QF-Adol might be essential to sick adolescents and they would recommend it to others.

Significance of results

We developed a DT-QF of nine questions for Portuguese adolescents (DT-QF-Adol), coined Protocolo de Perguntas da Terapia da Dignidade para Adolescentes — 10–18 anos. This tool can potentially be considered a good addition for pediatric palliative care.
Explosive Volcanic Eruption Powered by Water-Saturated Magma
Authors: Kornei Katherine
Published: September 2019

Little seismic unrest preceded the 2014 eruption of a stratovolcano in Indonesia, which suggests that the eruption was kick-started internally by volatile-triggered overpressure.
Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics
Authors: Wang Zhiyi , Ju Yanmin , Ali Zeeshan , Yin Hui , Sheng Fugeng , Lin Jian , Wang Baodui , Hou Yanglong
Published: September 2019

Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the field of theranostics. However, developing SDDSs with early diagnostic capability, enhanced drug delivery and efficient biodegradability still remains a scientific challenge. Herein, we report near-infrared light and tumor microenvironment (TME), dual responsive as well as size-switchable nanocapsules. These nanocapsules are made of a PLGA-polymer matrix coated with Fe/FeO core-shell nanocrystals and co-loaded with chemotherapy drug and photothermal agent. Smartly engineered nanocapsules can not only shrink and decompose into small-sized nanodrugs upon drug release but also can regulate the TME to overproduce reactive oxygen species for enhanced synergistic therapy in tumors. In vivo experiments demonstrate that these nanocapsules can target to tumor sites through fluorescence/magnetic resonance imaging and offer remarkable therapeutic results. Our synthetic strategy provides a platform for next generation smart nanocapsules with enhanced permeability and retention effect, multimodal anticancer theranostics, and biodegradability.
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
Authors: Black Samuel J. , Ozdemir Ahmet Y. , Kashkina Ekaterina , Kent Tatiana , Rusanov Timur , Ristic Dejan , Shin Yeonoh , Suma Antonio , Hoang Trung , Chandramouly Gurushankar , Siddique Labiba A. , Borisonnik Nikita , Sullivan-Reed Katherine , Mallon Joseph S. , Skorski Tomasz , Carnevale Vincenzo , Murakami Katsuhiko S. , Wyman Claire , Pomerantz Richard T.
Published: September 2019

DNA polymerase θ (Polθ) is a unique polymerase-helicase fusion protein that promotes microhomology-mediated end-joining (MMEJ) of DNA double-strand breaks (DSBs). How full-length human Polθ performs MMEJ at the molecular level remains unknown. Using a biochemical approach, we find that the helicase is essential for Polθ MMEJ of long ssDNA overhangs which model resected DSBs. Remarkably, Polθ MMEJ of ssDNA overhangs requires polymerase-helicase attachment, but not the disordered central domain, and occurs independently of helicase ATPase activity. Using single-particle microscopy and biophysical methods, we find that polymerase-helicase attachment promotes multimeric gel-like Polθ complexes that facilitate DNA accumulation, DNA synapsis, and MMEJ. We further find that the central domain regulates Polθ multimerization and governs its DNA substrate requirements for MMEJ. These studies identify unexpected functions for the helicase and central domain and demonstrate the importance of polymerase-helicase tethering in MMEJ and the structural organization of Polθ.
Quantification of porosity in extensively nanoporous thin films in contact with gases and liquids
Authors: Shpigel Netanel , Sigalov Sergey , Malchik Fyodor , Levi Mikhael D. , Girshevitz Olga , Khalfin Rafail L. , Aurbach Doron
Published: September 2019

Nanoporous layers are widely spread in nature and among artificial devices. However, complex characterization of extensively nanoporous thin films showing porosity-dependent softening lacks consistency and reliability when using different analytical techniques. We introduce herein, a facile and precise method of such complex characterization by multi-harmonic QCM-D (Quartz Crystal Microbalance with Dissipation Monitoring) measurements performed both in the air and liquids (Au-Zn alloy was used as a typical example). The porosity values determined by QCM-D in air and different liquids are entirely consistent with that obtained from parallel RBS (Rutherford Backscattering Spectroscopy) and GISAXS (Grazing-Incidence Small-Angle Scattering) characterizations. This ensures precise quantification of the nanolayer porosity simultaneously with tracking their viscoelastic properties in liquids, significantly increasing sensitivity of the viscoelastic detection (viscoelastic contrast principle). Our approach is in high demand for quantifying potential-induced changes in nanoporous layers of complex architectures fabricated for various electrocatalytic energy storage and analytical devices.
The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications
Authors: Götzke Hansjörg , Kilisch Markus , Martínez-Carranza Markel , Sograte-Idrissi Shama , Rajavel Abirami , Schlichthaerle Thomas , Engels Niklas , Jungmann Ralf , Stenmark Pål , Opazo Felipe , Frey Steffen
Published: September 2019

Specialized epitope tags are widely used for detecting, manipulating or purifying proteins, but often their versatility is limited. Here, we introduce the ALFA-tag, a rationally designed epitope tag that serves a remarkably broad spectrum of applications in life sciences while outperforming established tags like the HA-, FLAG®- or myc-tag. The ALFA-tag forms a small and stable α-helix that is functional irrespective of its position on the target protein in prokaryotic and eukaryotic hosts. We characterize a nanobody (NbALFA) binding ALFA-tagged proteins from native or fixed specimen with low picomolar affinity. It is ideally suited for super-resolution microscopy, immunoprecipitations and Western blotting, and also allows in vivo detection of proteins. We show the crystal structure of the complex that enabled us to design a nanobody mutant (NbALFAPE) that permits efficient one-step purifications of native ALFA-tagged proteins, complexes and even entire living cells using peptide elution under physiological conditions.
A bimodal soft electronic skin for tactile and touchless interaction in real time
Authors: Ge Jin , Wang Xu , Drack Michael , Volkov Oleksii , Liang Mo , Cañón Bermúdez Gilbert Santiago , Illing Rico , Wang Changan , Zhou Shengqiang , Fassbender Jürgen , Kaltenbrunner Martin , Makarov Denys
Published: September 2019

The emergence of smart electronics, human friendly robotics and supplemented or virtual reality demands electronic skins with both tactile and touchless perceptions for the manipulation of real and virtual objects. Here, we realize bifunctional electronic skins equipped with a compliant magnetic microelectromechanical system able to transduce both tactile—via mechanical pressure—and touchless—via magnetic fields—stimulations simultaneously. The magnetic microelectromechanical system separates electric signals from tactile and touchless interactions into two different regions, allowing the electronic skins to unambiguously distinguish the two modes in real time. Besides, its inherent magnetic specificity overcomes the interference from non-relevant objects and enables signal-programmable interactions. Ultimately, the magnetic microelectromechanical system enables complex interplay with physical objects enhanced with virtual content data in augmented reality, robotics, and medical applications.
Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
Authors: Menares Evelyn , Gálvez-Cancino Felipe , Cáceres-Morgado Pablo , Ghorani Ehsan , López Ernesto , Díaz Ximena , Saavedra-Almarza Juan , Figueroa Diego A. , Roa Eduardo , Quezada Sergio A. , Lladser Alvaro
Published: September 2019

Tissue-resident memory CD8+ T (Trm) cells mediate potent local innate and adaptive immune responses and play a central role against solid tumors. However, whether Trm cells cross-talk with dendritic cells (DCs) to support anti-tumor immunity remains unclear. Here we show that antigen-specific activation of skin Trm cells leads to maturation and migration to draining lymph nodes of cross-presenting dermal DCs. Tumor rejection mediated by Trm cells triggers the spread of cytotoxic CD8+ T cell responses against tumor-derived neo- and self-antigens via dermal DCs. These responses suppress the growth of intradermal tumors and disseminated melanoma lacking the Trm cell-targeted epitope. Moreover, analysis of RNA sequencing data from human melanoma tumors reveals that enrichment of a Trm cell gene signature associates with DC activation and improved survival. This work unveils the ability of Trm cells to amplify the breath of cytotoxic CD8+ T cell responses through DCs, thereby strengthening anti-tumor immunity.
Direct imaging of structural disordering and heterogeneous dynamics of fullerene molecular liquid
Authors: Choe Jeongheon , Lee Yangjin , Park Jungwon , Kim Yunho , Kim Chae Un , Kim Kwanpyo
Published: September 2019

Structural rearrangements govern the various properties of disordered systems and visualization of these dynamical processes can provide critical information on structural deformation and phase transformation of the systems. However, direct imaging of individual atoms or molecules in a disordered state is quite challenging. Here, we prepare a model molecular system of C70 molecules on graphene and directly visualize the structural and dynamical evolution using aberration-corrected transmission electron microscopy. E-beam irradiation stimulates dynamics of fullerene molecules, which results in the first-order like structural transformation from the molecular crystal to molecular liquid. The real-time tracking of individual molecules using an automatic molecular identification process elucidates the relaxation behavior of a stretched exponential functional form. Moreover, the directly observed heterogeneous dynamics bear similarity to the dynamical heterogeneity in supercooled liquids near the glass transition. Fullerenes on graphene can serve as a new model system, which allows investigation of molecular dynamics in disordered phases.