bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of Life Theory III. Maslow Revisited
Authors: Ventegodt Soren , Merrick Joav , Andersen Niels Jorgen
Published: March 2005

In 1962, Abraham Maslow published his bookTowards a Psychology of Being, and established a theory of quality of life, which still is considered a consistent theory of quality of life. Maslow based his theory for development towards happiness and true being on the concept of human needs. He described his approach as an existentialistic psychology of self-actualization, based on personal growth.When we take more responsibility for our own life, we take more of the good qualities that we have into use, and we become more free, powerful, happy, and healthy. It seems that Maslow�s concept of self-actualization can play an important role in modern medicine. As most chronic diseases often do not disappear in spite of the best biomedical treatments, it might be that the real change our patients have for betterment is understanding and living the noble path of personal development. The hidden potential for improving life really lies in helping the patient to acknowledge that his or her lust for life, his or her needs, and his or her wish to contribute, is really deep down in human existence one and the same. But you will only find this hidden meaning of life if you scrutinize your own life and existence closely enough, to come to know your innermost self.
Biochemical Changes in the Serum of Patients with Chronic Toxigenic Mold Exposures: A Risk Factor for Multiple Renal Dysfunctions
Authors: Anyanwu Ebere , Campbell Andrew W. , Vojdani Aristo , Ehiri John E. , Akpan Akpan I.
Published: March 2005

This paper analyzes and presents the biochemical abnormalities in the sera of patients presenting with chronic mycosis in order to investigate the relationship with the risks of multiple renal disorders. The study population (n = 10) consisted of six females and four males (mean age 36.3 years) exposed by toxic molds in their homes and offices for an average of 2.8 years. The control group comprised ten people, five males and five females (mean age 35.9 years) without any known exposures to toxic molds. Blood samples were obtained from both the patients and the controls and were processed using specific biochemical methods that included enzyme-linked immunoabsorbent assay (ELISA). There were biochemical abnormal concentrations in creatinine, uric acid, phosphorus, alkaline phosphotase, cholesterol, HDH, SGOT/AST, segmented neutrophils, lymphocytes, total T3, IgG and IgA immunoglobulins with significant differences between patients and controls. These abnormalities were consistent with multiple renal disorders. The major complaints of the mycosis patients were headaches, pulmonary symptoms, allergic reactions, memory loss, skin rashes, blurred vision symptoms, fatigue, and runny nose. These findings were depictive of a strong association of chronic mycosis with abnormal renal indicators. It was concluded that, although this research was a pilot investigation, based on the overall results, people exposed to chronic indoor environmental toxic molds were at risk of multiple renal complications.
Parent-Adolescent Conflict and Its Resolution in Monogamous and Polygamous Bedouin Arab Families in Southern Israel
Authors: Elbedour Salman , Hektner Joel M. , Morad Mohammed , Abu-Bader Soleman H.
Published: March 2005

The purpose of this study was twofold: (1) to compare whether children from polygamous family structures significantly differ from children from monogamous family structures with regard to the frequency of parent-child conflict, and (2) whether children from these two structures employ different patterns of family conflict resolution.To address these questions, a random sample of 212 high school students (60.8% monogamous) completed a self-administered survey. The results of MANOVA show no significant differences (p > 0.05) between these two structures with regard to the frequency of parent-child conflict. The results also show similar conflict management styles between these two family structures within each of the following five domains (privacy, school and career, money spending, going out and leisure, and physical appearance).This study is unique in that it is the first empirical research to be conducted in the field of conflict resolution among youth and adolescents in polygamous marital structures and therefore, further investigation is needed to replicate these results utilizing different cross-cultural populations practicing polygamy.
Clinical Holistic Medicine: Holistic Sexology and Treatment of Vulvodynia Through Existential Therapy and Acceptance Through Touch
Authors: Ventegodt Søren , Morad Mohammed , Hyam Eytan , Merrick Joav
Published: March 2005

Sexual problems are found in four major forms: lack of libido, lack of arousal and potency, pain and discomfort during intercourse, and lack of orgasm. It is possible to work with a holistic approach to sexology in the clinic in order to find and repair the negative beliefs, repressions of love, and lack of purpose of life, which are the core to problems like arousal, potency, and pain with repression of gender and sexuality. It is important not to focus only on the gender and genitals in understanding the patient's sexual problems. It is of equal importance not to neglect the body, its parts, and the feelings and emotions connected to them. Shame, guilt, helplessness, fear, disgust, anger, hatred, and other strong feelings are almost always an important part of a sexual problem and these feelings are often “held” by the tissue of the pelvis and sexual organs. The patient with sexual problems can be helped both by healing existence in general and by discharging old painful emotions from the tissues. The later process of local healing is often facilitated by a simple technique: accepting contact via touch. This is a very simple technique, where the self-acceptance of the patient is to be promoted, for example, asking the female patient to put her hand on her stomach (uterus) or vulva, after which the holistic physician puts his hand supportively around hers. When done with care and after obtaining the necessary trust of the patient, this aspect of holding often releases the old negative emotions of shame bound to the touched areas. Afterwards, the emotional problems become a subject for conversational therapy and further holistic processing. Primary vulvodynia seems to be one of the diseases that can be cured after only a few successful sessions of working with acceptance through touch. The technique can be used as an isolated procedure or as a part of a pelvic examination. When touching the genitals with the intention of sexual healing, a written therapeutic contract with the patient is highly recommended and a strict ethical code is necessary to avoid malpractice. As about one woman in three suffers from sexual problems, many of which seemingly can be efficiently alleviated by the simple holistic techniques of “holding and processing”, it is very important that the holistic physician is also trained to work in the sexual sphere in order to be able to support his patients fully.
Quality of Life: A Case Report of Bullying in the Workplace
Authors: Shahtahmasebi Said
Published: March 2005

The literature on bullying in the workplace describes the mental and physical ill health suffered by the victims and their families as the consequences of the bullying. The literature also discusses methods of bullying such as overt and covert physical and psychological abuse. The implications are that the consequences of abuse go far beyond the intended target; from impact on the working environment to individuals health to economic and financial loss. The literature suggests various recommendations to employers and managers to combat bullying at work. However, the common assumption within the literature has been that the bullying is done by a colleague, a line manager, or middle manager. Furthermore, it is often assumed that the executive/vice-chancellor, human resources, the trustees, or the governing board are unaware of bullying in their workplace. In this article, it is argued that cases of bullying (whether due to isolated individuals, competition, rivalry, power, or pure meanness as is reported in the literature) can only thrive in a bullying management culture. Therefore, debate and policy formulation must be directed at government level in the first instance. The case report is intended to raise some relevant issues to stimulate a debate and more research in this area.
Ammonia Emission and Deposition in Scotland and Its Potential Environmental Impacts
Authors: Sutton M.A. , Dragosits U. , Hellsten S. , Place C.J. , Dore A.J. , Tang Y.S. , van Dijk N. , Love L. , Fournier N. , Vieno M. , Weston K.J. , Smith R.I. , Coyle M. , Roy D. , Hall J. , Fowler D.
Published: March 2005

The main source of atmospheric ammonia (NH3) in Scotland is livestock agriculture, which accounts for 85% of emissions. The local magnitude of emissions therefore depends on livestock density, type, and management, with major differences occurring in various parts of Scotland. Local differences in agricultural activities therefore result in a wide range of NH3emissions, ranging from less than 0.2 kg N ha−1year−1in remote areas of the Scottish Highlands to over 100 kg N ha−1year−1in areas with intensive poultry farming. Scotland can be divided loosely into upland and lowland areas, with NH3emission being less than and more than 5 kg N ha−1year−1, respectively.Many semi-natural ecosystems in Scotland are vulnerable to nitrogen deposition, including bogs, moorlands, and the woodland ground flora. Because NH3emissions occur in the rural environment, the local deposition to sensitive ecosystems may be large, making it essential to assess the spatial distribution of NH3emissions and deposition. A spatial model is applied here to map NH3emissions and these estimates are applied in atmospheric dispersion and deposition models to estimate atmospheric concentrations of NH3and NH4+, dry deposition of NH3, and wet deposition of NHx. Although there is a high level of local variability, modelled NH3concentrations show good agreement with the National Ammonia Monitoring Network, while wet deposition is largest at high altitude sites in the south and west of Scotland. Comparison of the modelled NHxdeposition fields with estimated thresholds for environmental effects (“critical loads”) shows that thresholds are exceeded across most of lowland Scotland and the Southern Uplands. Only in the cleanest parts of the north and west is nitrogen deposition not a cause for concern. Given that the most intense effects occur within a few kilometres of sources, it is suggested that local spatial abatement policies would be a useful complement to traditional policies that mitigate environmental effects based on emission reduction technologies.
Raphanus sativus (Radish): Their Chemistry and Biology
Authors: Gutiérrez Rosa Martha Pérez , Perez Rosalinda Lule
Published: March 2005

Leaves and roots ofRaphanus sativushave been used in various parts of the world to treat cancer and as antimicrobial and antiviral agents. The phytochemistry and pharmacology of this radish is reviewed. The structures of the compounds isolated and identified are listed and aspects of their chemistry and pharmacology are discussed. The compounds are grouped according to structural classes.
Clinical Holistic Medicine: Holistic Pelvic Examination and Holistic Treatment of Infertility
Authors: Ventegodt Søren , Morad Mohammed , Merrick Joav
Published: March 2005

In clinical holistic practice, it is recommended that ample time is spent with the gynecological or pelvic examination, especially in cases of women with suspected old emotional traumas following early childhood cases of incest or sexual abuse. The holistic principles of holding and processing should be followed with the purpose of healing the patient, re-establishing the natural relationship with the body, sexuality, and reproductive organs. Sexual violations are often forcibly repressed. It appears that the tissues that were touched during the violation often bear the trauma. It is characteristic of these patients that their love lives are often problematic and do not provide the necessary support to heal the old wounds in the soul and therapy is therefore indicated. When this is concerned with the reproductive organs, it poses particular difficulties, as the therapy can easily be experienced as a repetition of the original violation, not least due to the risk of projection and transference. There is, therefore, a need for a procedure that is familiar to and safe for the patient, for all work that involves therapeutic touching of sexual organs over and beyond what is standard medical practice. This paper presents one case story of earlier child sexual abuse and one case of temporary infertility. We have established a procedure of slow or extended pelvic examination, where time is spent to make the patient familiar with the examination and accept the whole procedure, before the treatment is initiated. The procedure is carried out with a nurse, and 3 h are set aside. It includes conversation on the present condition and symptoms; concept of boundaries; about how earlier assaults can be projected into the present; establishment of the therapeutic room as a safe place; exercises on when to say stop; therapeutic touch; visualization of the pelvic examination step by step beforehand; touching on the outside of the clothes with repetition of the stop procedure if necessary; pelvic examination paying special attention to traumatized (damaged/scarred/blocked) areas with feel, acknowledge, and let go of the traumatized areas; postprocessing of emotions and traumas with final healing. The patient cannot be healed until negative decisions are found and dropped with a tour back to the present, to let go of negative sentences and ideas, and a plan for further positive progress.
Pilonidal Sinus of the Glans Penis Associated withActinomycesCase Reports and Review of Literature
Authors: Chikkamuniyappa Shylashree , Furman Jaime , Scott Rolf Sjuve
Published: March 2005

Pilonidal sinus is a well-recognized condition that occurs most commonly in the sacrococcygeal area of younger men. It is hypothesized to be an acquired chronic inflammation condition due mainly to hair trapped beneath the surface. A pilonidal sinus in the sacrococcygeal region is associated with recurrent infection, abscess formation, cellulitis, fistulae, and rarely, squamous cell carcinoma. A pilonidal sinus of the penis is a rare entity. The association of a penile pilonidal cyst and Actinomyces is even more uncommon with only three cases reported previously. Two cases of pilonidal sinus are reported in this paper. One of the cases was associated with actinomycosis. Pilonidal sinus of the penis should be considered in the clinical and pathological differential diagnosis and has to be distinguished from balanoposthitis, epidermal cyst, and carcinoma. The knowledge about possible association with actinomycosis is important to ensure early treatment.
Computed Energetics of Nucleotides in Spatial Ribozyme Structures: An Accurate Identification of Functional Regions from Structure
Authors: Torshin Ivan Y.
Published: March 2005

Ribozymes are functionally diverse RNA molecules with intrinsic catalytic activity. Multiple structural and biochemical studies are required to establish which nucleotide bases are involved in the catalysis. The relative energetic properties of the nucleotide bases have been analyzed in a set of the known ribozyme structures. It was found that many of the known catalytic nucleotides can be identified using only the structure without any additional biochemical data. The results of the calculations compare well with the available biochemical data on RNA stability. Extensivein silicomutagenesis suggests that most of the nucleotides in ribozymes stabilize the RNA. The calculations show that relative contribution of the catalytic bases to RNA stability observably differs from contributions of the noncatalytic bases. Distinction between the concepts of “relative stability” and “mutational stability” is suggested. As results of prediction for several models of ribozymes appear to be in agreement with the published data on the potential active site regions, the method can potentially be used for prediction of functional nucleotides from nucleic sequence.
Retroperitoneal Ganglioneuroma Encasing the Celiac and Superior Mesenteric Arteries
Authors: Nelms Justin K. , Diner Eric K. , Lack Ernest E. , Patel Sunil V. , Ghasemian Seyed R. , Verghese Mohan
Published: March 2005

Ganglioneuroma is a rare neoplasm arising from the sympathoadrenal neuroendocrine system and has anatomic distribution paralleling the sympathetic chain ganglia and the adrenal medulla. In some cases, ganglioneuroma is the end stage maturation of less-differentiated neoplasms such as neuroblastoma or ganglioneuroblastoma, but based on age at diagnosis (over 10 years of age) and anatomic location, many of these tumors appear to arisede novo. It must be included in the differential diagnosis of posterior mediastinal and retroperitoneal mass. We report a case of retroperitoneal ganglioneuroma involving the celiac axis and superior mesenteric arteries in a 40-year-old female.
The Use of Plants for Remediation of Metal-Contaminated Soils
Authors: Vassilev Andon , Schwitzguebél Jean-Paul , Thewys Theo , van der Lelie Daniël , Vangronsveld Jaco
Published: March 2005

The use of green plants to remove, contain, inactivate, or degrade harmful environmental contaminants (generally termed phytoremediation) is an emerging technology. In this paper, an overview is given of existing information concerning the use of plants for the remediation of metal-contaminated soils. Both site decontamination (phytoextraction) and stabilization techniques (phytostabilization) are described. In addition to the plant itself, the use of soil amendments for mobilization (in case of phytoextraction) and immobilization (in case of phytostabilization) is discussed. Also, the economical impacts of changed land-use, eventual valorization of biomass, and cost-benefit aspects of phytoremediation are treated. In spite of the growing public and commercial interest and success, more fundamental research is needed still to better exploit the metabolic diversity of the plants themselves, but also to better understand the complex interactions between metals, soil, plant roots, and micro-organisms (bacteria and mycorrhiza) in the rhizosphere. Further, more demonstration experiments are needed to measure the underlying economics, for publicacceptance and last but not least, to convince policy makers.
Skeletal Calcium/Phosphorus Ratio Measuring Techniques and Results. I. Microscopy and Microtomography
Authors: Kyriazis Vassilios , Tzaphlidou Margaret
Published: March 2005

An approach to the problem of bone disorders is the measurement of the skeleton's static and dynamic strength, an estimate of which is bone mineral density. A decrease in the latter may be due to a decrease in either Ca or P, or to dissimilar decreases in both. Consequently, the determination of the Ca/P ratio may provide a sensitive measure of bone mineral changes and may add to our understanding of the changes occurring in bone diseases. This paper reviews techniques such as transmission electron microscopy (TEM) and micro-computed tomography (μu-CT), which have been developed for thein vitroassessment of the Ca,P content and the skeletal Ca/P ratio. Their main aspects are presented, as much as results regarding the referred values. The presentation of otherin vitroorin vivotechniques, such as instrumental neutron activation analysis (INAA) or X-ray absorptiometry accordingly, would be the issue of another article. The authors argue that the choice of the best technique relies on its cost ad ease of applicability, its reliability, and precision.
Tuberculous Pyonephrosis Involving Duplex Kidney: First Reported Case
Authors: Bhatty Tanweer A.N. , Alkhayat Ahmed M.
Published: March 2005

We report a case of tuberculosis (TB) involving duplex kidney that has not been reported in the literature so far. Conservative surgery was done, which was effective in our case.
Taurine Prevents Ibuprofen-Induced Gastric Mucosal Lesions and Influences Endogenous Antioxidant Status of Stomach in Rats
Authors: Balasubramanian T. , Somasundaram M. , Felix A. John William
Published: March 2005

Recently, free radicalinduced tissue damage is implicated in the nonsteroidal anti-inflammatory drugs (NSAIDs)involved gastric mucosal lesion. Administration of taurine, an endogenous antioxidant, is reported to be beneficial in various clinical conditions. Therefore, we decided to study the protective effect of taurine in ibuprofen-induced gastropathy and the effects of administration of taurine on the endogenous antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), and reduced glutathione (GSH) of stomach. In rats, administration of taurine orally for three consecutive days (250 mg/kg body weight) protected the gastric mucosa from ibuprofen-induced, acute gastric mucosal lesion. In ibuprofen-treated rats, the lipid peroxidation measured as thiobarbituric acid reactive substances (TBARS), a marker for free radicalinduced tissue damage, is also significantly decreased by taurine. Ibuprofen treatment resulted in a significant increase in the activities of total SOD, manganese SOD (Mn-SOD), and GPX and reduced GSH. Taurine administration in ibuprofen-treated rats also showed a significant increase in the activities of the antioxidant enzymes namely total SOD, Mn-SOD, GPX, CAT, and the level of reduced GSH. The activity of copper-zinc SOD enzyme (Cu-Zn SOD) is not affected by ibuprofen or taurine. There is no temporal relation between the antioxidant status of the stomach and the tissue damage following oral administration of ibuprofen or taurine.
Torted and Ruptured Wandering Spleen Presenting as a Surgical Emergency in Pregnancy
Authors: Parvaiz A. , Chandran S. , Karim A. , Kumar K. , Jeffrey P. , Lagattolla N.R.F.
Published: March 2005

Wandering spleen (WS) is characterised by incomplete fixation of the spleen to its supporting linorenal and gastrosplenic ligaments. It can predispose to life-threatening complications due to torsion of its vascular pedicle, splenic infarction, portal hypertension, and haemorrhage. A 27-year-old, 36-week prima gravida underwent emergency caesarean section for tachycardia and hypotension. A healthy baby girl was delivered. However, she remained shocked despite aggressive fluid therapy and intraoperatively it was noted that there was significant intraperitoneal bleeding and the on-call surgical team was summoned. Midline laparotomy revealed a lacerated, infarcted, hypermobile spleen found with free intraperitoneal bleeding. The unsalvageable spleen was resected and the patient went on to make an excellent recovery. The aetiology of WS is contentious. With an increased frequency among multiparous females of reproductive age, some suggest the hormonal effects of pregnancy as contributing factors. Clinical presentations range from an asymptomatic abdominal mass to acute abdominal pain with hypovolaemic shock. WS poses a serious threat to life due to thrombosis, bleeding, or infarction. Ultrasound scan and CT scan are equally effective in the diagnosis. Patients with asymptomatic WS should be treated with elective splenopexy, however, in the acute presentation, splenectomy is the procedure of choice.
Role of Various Extractants in Removing Group-IIB Elements of Soils Incubated with EDTA
Authors: Karak Tanmoy , Singh Uttam Kumar , Das D. K.
Published: March 2005

This paper presents the results of an experimental investigation undertaken to evaluate different extractant solutions viz. HCl, Mg(NO3)2, and DTPA with the range of concentration from 0.001 to 0.1Nafter incubation with group-IIB metals (Zn, Cd, and Hg) and EDTA to understand the capability to remove Zn, Cd, and Hg from soils. Two noncontaminated soils, one acidic (GHL) and the other alkaline (KAP), in reaction were taken from an agricultural field of West Bengal, India for this investigation. Experiments were conducted on these two soils spiked with ZnII, CdII, and HgIIin concentrations of 612, 321, and 215 mg/kg for soil GHL and 778, 298, and 157 mg/kg for soil KAP, respectively, which simulate typical electroplating waste contamination. The removal of Zn, Cd, and Hg in soil GHL within the range of HCl concentrations was 8.216.5, 12.219.1, and 4.36.9 whereas these were 6.57.6, 8.514.1, and 3.25.2 in soil KAP. The removal of Zn, Cd, and Hg in soil GHL within the range of Mg(NO3)2concentrations were 12.228.5, 19.124.6, and 18.219.1 whereas these were 9.112.1, 8.312.1, and 10.648.1 in soil KAP. For DTPA extractant, the percent removal of metal was found to be significantly higher than the other two extractants, which corroborates that DTPA is a better extractant for soil cleaning.
Ocular Defects in Photosensitive Epilepsy
Authors: Anyanwu Ebere C. , Ehiri John
Published: March 2005

Patients with photosensitive epilepsy are susceptible to seizures due to photoparoxysmal response (PPR). This response adversely precipitates factors that modify the functional status of the visual system. Such factors may or may not be evident superficially, but may lead to ocular defects due to trauma, hormonal imbalance, abnormal intraocular pressure (IOP), or any other reflex-inducing stimuli. The extent to which photosensitive epileptic patients suffer from PPR-related ocular defects has not been documented fully. In this investigation, ocular defects in patients with photosensitive epilepsy are studied using visual-evoked response (VER). A total of 212 photosensitive epileptic patients were studied to ascertain the magnitude and distribution of ocular defects using the changes in EEG and visual-evoked potential (VEP); 51% of the patients were female, the age range was 146 years. The major ocular defects and complications found were visual field defects, optic nerve abnormalities, nystagmus, cataracts, amblyopia, and migraine. These findings were analyzed according to age and sex. The relationship between the ocular abnormalities and the interpretations of the changes in the characteristics of the VEP indicated that optic-related atrophies, visual defects, optic neuritis, chiasmal compression, nystagmus, migraine headache, cataracts, and amblyopia were prevalent in photosensitive epileptic patients at varying degrees. The results showed that although ocular defects in photosensitive epilepsy may not be obvious differentially, VEP can be used in their diagnosis, contrary to earlier studies reporting that VEP is not of much value in epilepsy diagnosis.
Historical Transition of Eco-Structure in a Tidal Flat Caused by Expansion of Sewerage Treatment Area
Authors: Tatsumoto Hideki , Ishii Yuichi , Machida Motoi , Taki Kazuo
Published: March 2005

An artificial tidal flat was prepared for the mitigation tool on coastal environment. However, it is considered that most of the flat was not restored to the sufficient amenities for aquatic living things, migratory birds, etc. because none of the ecological mechanisms were understood or planned for. It is therefore investigated in this paper that historical transition factors in ecosystem structure are selected and traced with the diffusion of a public sewerage system, and with environmental factors such as water quality, sediment condition, and aquatic producers in the Yatsu Tidal Flat. As a result, it can be defined that the tidal flat, just like a lagoon, was formed artificially with reclamation and development of its circumference at the first step of transition; the water quality and sediment condition gradually became brackish water and muddy sediment conditions, interactively. The ecosystem pyramid forming orderly layers according to trophic level appeared as a high-bio-production potential in its tidal flat. In the second step, i.e., in recent years, the characteristics of water quality and sediment conditions evolved into a foreshore tidal flat, namely, conditions in the flat observed were that the progression of water included a high concentration of chloride ion as seawater and sediment conditions became sandy. Because of that, the inflowing fresh water and organic mater from the land area decreased with the improvement of the public sewerage system. The ecosystem pyramid was distorted into a chaos pyramid, with inversion ofUlvaspp.
Quantified Hypoxia and Anoxia in Lakes and Reservoirs
Authors: Nürnberg Gertrud K.
Published: March 2005

Hypoxia and anoxia occur frequently in freshwater systems and have biological and chemical implications.Anoxiacan be expressed and quantified as the anoxic factor;hypoxia, for a specific level of oxygen depletion, can be expressed as the hypoxic factor in lakes, reservoirs, and river sections. These methods summarize information of individual dissolved oxygen profiles as annual values or factors that facilitate comparison between and within lakes. Therefore, these factors are useful in the formulation and testing of hypotheses related to the dissolved oxygen status in water bodies. Methods of calculating different factors for different oxygen levels and water layers, including those applying separately to the epilimnion and hypolimnion, are presented in detail. Proven and potential applicability include: (1) the quantification of relationships with lake water quality variables and lake classification (trophic state), (2) the evaluation of restoration techniques with respect to their effects on hypolimnetic oxygen depletion, (3) the determination of internal phosphorus loading in stratified and polymictic lakes, (4) the exploration of habitat constraints due to hypoxia (e.g., fish species richness and winterkill), (5) forecasting potential effects of climatic change on oxygen content and internal phosphorus loading, and (6) the establishment and examination of criteria and guidelines with respect to hypoxia by custom-made definitions.
Clinical Holistic Medicine: Applied Consciousness-Based Medicine
Authors: Ventegodt Søren , Merrick Joav
Published: March 2005

Consciousness-based medicine is our term for a form of medical treatment that works by direct appeal to the consciousness of the patient, in contrast to modern biomedical treatment where drugs are used to affect body chemistry. With this concept, maybe we are (in a sense) turning back to the “old medicine”, where the family physician was the all-concerned “old country doctor” who knew the child, the siblings, the parents, the family, and the village. In a series of papers on clinical holistic medicine, we would like to present the classic art of healing, where the physician works mostly with his hands, then show how the modern biomedical physician performs with biochemistry, and finally introduce consciousness-based medicine. Some of our questions will be: If you improve your quality of life, will you also improve your health? Will learning more about yourself bring more purpose in your life? Will finding someone to live with in a loving and mutually respectful relationship improve your health? Scientists and thinkers like Antonovsky, Frankl, Maslow, and Jung have pointed to love as a unique way to coherence in life, and thus to biological order and a better health. Several scientific studies have also suggested that patients who focus on improving their quality of life usually will not follow the general statistics for survival, since somehow other factors are at play, which sometimes you will find referred to as “exceptional”.
(+)-Discodermolide: A Marine Natural Product Against Cancer
Authors: De Souza Marcus Viníus Nora
Published: March 2005

(+)-Discodermolide was isolated in 1990 by Gunasekera et al. from the deep-water Caribbean sponge Discodermia dissoluta. It attacks cancer cells in a similar way to the successful cancer drug Taxol® that has become the best-selling anticancer drug in history. Taxol is also the first natural product described that stabilizes the microtubules involved in many aspects of cellular biology and that represent an important target of anticancer chemotherapeutics. However, (+)-discodermolide appears to be far more potent than Taxol® against tumors that have developed multiple-drug resistance, with an IC50in the low nanomolar range. Due to these excellent results, this natural product was licensed to Novartis Pharmaceutical Corporation in early 1998. The present review covers the history, biological activity, total synthesis, and synthetic analogs of (+)-discodermolide.
Intellectual Disability and Parenthood
Authors: Kandel Isack , Morad Mohammed , Vardi Gideon , Merrick Joav
Published: March 2005

Parenthood in persons with intellectual disability (ID) is an issue of concern for the family, guardians, and professionals as there are many sentiments and problems involved: financial, technical, medical, legal, and above all moral. People with intellectual, developmental, or other disabilities have feelings, want relationships, and are able to have children also. The attitude of society has changed through time from the early eugenic concern with heredity and fertility, to a focus on the risk to the children due to parental neglect or abuse, to acceptance and a search for solutions to parental training and support. This change can be seen as a result of a shift from institutional care to community care and normalization. This paper reviews available research, prevalence, service issues, experience from around the world, and relates to the situation in Israel. Jewish Law has been very progressive regarding the possibility of marriage between persons with ID (in contrast to American Law where historically this right has been denied, until recently). Recent research has shown that, in the case of such a union resulting in children, although they requiresomesupervision, family, friends, and social welfare agencies have scrutinized these families so much they are in constant fear of their child being taken away. There is little information on the number of such cases and an overall dearth of information on the effects on the children, although one recent study from the U.K. has shown a varied picture of resilience and a close, warm relationship later on with the family and especially the mother.
Health Policy for Persons with Intellectual Disability: Experiences from Israel
Authors: Halperin Ilana , Shupac Aliza , Morad Mohammed , Merrick Joav
Published: March 2005

Intellectual disability (ID) is a life-long disability characterized by impaired cognitive and adaptive skills. Over the past few decades, a shift has occurred in the conceptualization and treatment of people with ID and research in health policy and health-care delivery has become increasingly global with a notable disparity between the developed and developing world. This review presents a literature overview of global health policy for ID with the intent to focus specifically on the policy and treatment within Israel. The methodology involved sites visits to care centers, discussions with stakeholders in health policy, and a literature review. We believe that Israel is in a unique position between a developed and developing culture. In particular, the distinct problems faced by the Arab and Bedouin community in terms of ID must be formally accounted for in Israel's future policies. Research from the developing world would be instructive to this end. The global approach in this presentation led to certain policy recommendations that take into account the uniqueness of Israel's position from a social, economic, religious, and demographic perspective. It is the hope that this paper will lead to an increased awareness of the challenges faced by persons with ID and their providers in all sectors of Israeli society and that the necessary policy recommendations will ultimately be adopted.
Mineralogical Composition of the Urinary Stones from Different Provinces in Iraq
Authors: Afaj Adnan H. , Sultan Meitham A.
Published: March 2005

For this study, 25 samples of urinary stones were chosen from different provinces in Iraq as representative sampling localities. These samples of urinary stones were collected to represent kidney, urate, and bladder stones. The main objectives of this study are to try to shed some light on the possibilities of tracking down the effective environmental factors that determine the mineralogical and chemical composition of these stones. The stones were examined using several techniques, the most important of which was the use of the X-ray diffraction (XRD) technique to determine the mineralogical composition of these stones. A scanning electron microscopy (SEM) test was conducted to determine the crystallographic forms and structures for the minerals forming these stones. Optical properties of these minerals were studied using a polarizing microscope. All these techniques revealed that the calcium oxalate, represented in Whewellite mineral, is the most dominant type of these stones, in addition to other minerals such as Hydroxy apatite, Struvite, and Uricite. Dittmarite was pointed out for the first time ever in some samples. This mineral has not been determined in any previous study worldwide.Considering the results of mineralogical and chemical examinations of the urinary stones in question, and the statistical information gathered from the Iraqi Health Ministry, statistical analyses were applied. The ratio of male-female cases in this study happened to be 4:1, which was higher than the ratio in the years 1988–1989 and 1993–1994, 2:1; 3:1 respectively. The highest percentage of the cases was in the 15–50 age group, which is considered as the most productive years of human lifetime. This study showed that one of the most significant factors was that the mineralogical variation of urinary stones in some Iraqi provinces was due to geographical differences, which reflect the variation in lithogenic factors and also climatological factors. Other factors may be socioeconomic, genetic, physiological, and pathological, which remain the important factors in forming urinary stones.
Speed-Accuracy Tradeoff Operator Characteristics of Endogenous and Exogenous Covert Orienting of Attention
Authors: McCormick Peter A. , Francis Lori
Published: March 2005

There is debate over the mechanisms that govern the orienting of attention. Some argue that the enhanced performance observed at a cued location is the result of increased perceptual sensitivity or preferential access to decision-making processes. It has also been suggested that these effects may be the result of trades in speed for accuracy on the part of the observers. In the present study, observers performed either an exogenous or an endogenous orienting of attention task under both normal instructions (respond as quickly and as accurately as possible) and speeded instructions that used a deadline procedure to limit the amount of time observers had to complete a choice reaction time (CRT) task. An examination of the speed-accuracy operating characteristics (SAOCs) yielded evidence against the notion that CRT precuing effects are due primarily to a tradeoff of accuracy for speed.
Clinical Holistic Medicine: Chronic Infections and Autoimmune Diseases
Authors: Ventegodt Søren , Merrick Joav
Published: March 2005

The consciousness-based (holistic) medical toolbox might be useful in general practice and in cases of recurrent infections and chronic infection or inflammation. From our clinical experiences, there is hope for improvement from a number of diseases caused by disorders affecting the regulation of the immune system when the physician includes the holistic medical approach.Our scientific understanding of the connection between consciousness and cellular order is still limited. Consciousness-based holistic medicine removes (as explained by the holistic process theory of healing) the “blockages” in the tissues of the body and facilitates function and informational exchange of the cells of the body. Many blockages and repressed feelings in an area would imply “noise and disturbances” on the level of intercellular communications, which in turn means major difficulties for the cells of the immune system. For this they are totally dependent on the body information system, which the holistic treatment aims to recover. Processing the blockages increases the coherence of the cells and organism, thus increasing the intercellular flow of information in the area and thus strengthening the immune defense and healing the disease. The area of clinical holistic medicine is going through a rapid development and the toolbox of consciousness-based medicine is available for dealing with many diseases arising from disturbances in the regulation of the immune system. Holistic medicine has yet to be better explained scientifically and our proposed holistic cures have yet to be documented clinically. We invite the medical community to cooperate on this important challenge.
Impacts of Extraction Methods in the Rapid Determination of Atrazine Residues in Foods using Supercritical Fluid Chromatography and Enzyme-Linked Immunosorbent Assay: Microwave Solvent vs. Supercritical Fluid Extractions
Authors: El-Saeid Mohamed H. , Kanu Ijeoma , Anyanwu Ebere C. , Saleh Mahmoud A.
Published: March 2005

It is an accepted fact that many food products that we eat today have the possibility of being contaminated by various chemicals used from planting to processing. These chemicals have been shown to cause illnesses for which some concerned government agencies have instituted regulatory mechanisms to minimize the risks and the effects on humans. It is for these concerns that reliable and accurate rapid determination techniques are needed to effect proper regulatory standards for the protection of people's nutritional health. This paper, therefore, reports the comparative evaluation of the extraction methods in the determination of atrazine (commonly used in agricultural as a herbicide) residues in foods using supercritical fluid chromatography (SFC) and enzyme-linked immunosorbent assay (ELISA) techniques. Supercritical fluid extraction (SFE) and microwave solvent extraction (MSE) methods were used to test samples of frozen vegetables, fruit juice, and jam from local food markets in Houston. Results showed a high recovery percentage of atrazine residues using supercritical fluid coupled with ELISA and SFC than with MSE. Comparatively, however, atrazine was detected 90.9 and 54.5% using SFC and ELISA techniques, respectively. ELISA technique was, however, less time consuming, lower in cost, and more sensitive with low detection limit of atrazine residues than SFC technique.
The Hrp pathogenicity island of Erwinia amylovora and identification of three novel genes required for systemic infection‡
Authors: OH CHANG‐SIK , KIM JIHYUN F. , BEER STEVEN V.
Published: March 2005

Sequence analysis of the region bordering the hrp/dsp gene cluster of Erwinia amylovora strain Ea321, which causes fire blight, revealed characteristics of pathogenicity islands (PAIs). Included are genes for a phage integrase, a tRNAPhe, several orthologues of genes of YAPI, a PAI of Yersinia pseudotuberculosis, and several putative virulence genes with HrpL‐dependent promoter motifs. The island is designated the Hrp PAI of E. amylovora. It is comprised of a chromosomal region of c. 62 kb with 60 open reading frames (ORFs). Comparison of the Hrp PAI of E. amylovora with those of four closely related bacteria showed that orfB, a homologue of avrBsT of Xanthomonas campestris pv. vesicatoria, and orfA, its putative chaperone gene, are present only in the Hrp PAI of E. amylovora. As regions flanking the hrp/dsp gene cluster are quite diverse, addition and deletion may have occurred during divergent evolution of the five bacteria. Among ORFs of the PAI of Ea321, three new HrpL‐dependent genes were identified. Because they are required for full virulence in apple, they were designated hsvC, hsvB and hsvA (hrp‐associated systemic virulence). They encode a homologue of an amidinotransferase for phaseolotoxin biosynthesis and homologues of a nikkomycin‐biosynthetic protein of Pseudomonas syringae.
An atypical 3′‐controller element mediates low‐level transcription of the p6 subgenomic mRNA of Citrus tristeza virus
Authors: AYLLÓN MARÍA A. , SATYANARAYANA TATINENI , GOWDA SIDDARAME , DAWSON WILLIAM O.
Published: March 2005

Citrus tristeza virus (CTV) has within the 3′‐half of the genome ten open reading frames (ORFs) that are expressed through a series of 3′‐coterminal subgenomic (sg) messenger (m)RNAs that, in general, function as monocistronic mRNAs with only the 5′‐most ORF translated. Yet only nine sg mRNAs have been detected, suggesting that ORF 3, which is predicted to encode a small hydrophobic protein of ∼6 kDa (p6), might be expressed in some other manner, perhaps from a functionally dicistronic sg mRNA. However, when we positioned the p6 gene near the 3′‐terminus of a minimal CTV replicon to amplify greatly the level of production of the putative sg mRNA, we found a minimal level of a p6 mRNA, thus providing evidence for a separate mRNA for each 3′ ORF. The 5′ termini of the sg mRNAs and the cis‐acting elements (controller elements—CEs) that regulate the production of the p6 gene and the adjacent HSP70h (heat shock protein 70 homologue) were located further upstream of the ORFs compared with the other CTV CEs. Both preferentially initiated synthesis with an adenylate, as has been shown for the more highly expressed 3′ genes; but in contrast, the p6 sg mRNA occasionally initiated with a guanylate. Although the nucleotide sequences and the computer‐predicted secondary structures of the HSP70h CE were similar to those previously described for other 3′ CEs, those of the p6 CE were quite different, suggesting that CE strength is related to proximity to an ideal CE conformation. The lack of similarity between different CTV CEs led us to examine how well the CTV replicase complex could initiate sg mRNAs from CEs from different members of the family Closteroviridae. We found that the CTV replicase complex efficiently initiated production of sgRNAs from the p6 and HSP70h CEs from Beet yellows virus, with the HSP70h CE initiating at the same nucleotide as within the homologous virus, indicating that the mode of recognition of the CEs is similar. However, CEs from a more distantly related member of the Closteroviridae, Lettuce infectious yellows virus, did not function to produce sg mRNAs in CTV.