bluuebunny/crossref_metadata_2025 huggingface dataset:
“A hitherto unheard‐of and harmful thing”: Breastfeeding and Violence in Russian Literature
Authors: Maguire Muireann
Published: April 2023

This article examines the construction of maternal subjectivity in the context of breastfeeding narratives in Russian literature, from the early 1800s to the 1920s. It draws on historical and contemporary socio‐economic contexts, in Russia and the West, to support its major contention that, in literature, breastfeeding and violence are intrinsically connected at a symbolic level. As a literary trope, breastfeeding tends to be presented either as the antithesis of violence (as in the passages analysed from Shakespeare’s Macbeth and Krylov’s Fables) or as a continuation of underlying structural violence (with examples from Korolenko, Tolstoy, and Dostoevsky). Through three detailed close readings of fictions by Ivan Lazhechnikov (the 1859 novella “My Doctor’s Grimace”), Mikhail Voskresenskii (the 1858 novel Natasha Podgorich), and Vsevolod Ivanov (the 1922 short story “The Child”), I argue that realist literary depictions of maternal breastfeeding and wet‐nursing demonstrate both the social vulnerability of mothers and the temporary autonomy or even sanctuary gained through these practices. I apply Bourdieu’s definition of “symbolic violence” and Cixous’s notions of “white ink” and “écriture féminine” to the context of Russian maternal fictions. I conclude that the characterization of nursing mothers in Russian realist literature is both revelatory and subversive.
A split GAL4 RUBY assay for visual in planta detection of protein–protein interactions
Authors: Chen Jian , Luo Ming , Hands Phillip , Rolland Vivien , Zhang Jianping , Li Zhao , Outram Megan , Dodds Peter , Ayliffe Michael
Published: April 2023

Protein–protein interactions (PPIs) are a fundamental process in cellular biogenesis. Here we have developed a split GAL4 RUBY assay that enables macroscopically visual PPI detection in plant leaves in real time. Candidate interacting protein partners are fused to specific domains of the yeast GAL4 and herpes simplex virus VP16 transcription factors and transiently expressed in Nicotiana benthamina leaves by Agrobacterium infiltration. PPI, that may be either direct or indirect, results in transcriptional activation of a RUBY reporter gene leading to the production of the highly visual metabolite, betalain, in leaf tissue of living plants. Samples require no processing for in planta visual qualitative assessment, but with very simple processing steps the assay is quantitative. Its accuracy is demonstrated using a series of known interacting protein partners and mutant derivatives including transcription factors, signalling molecules and plant resistance proteins with cognate pathogen effectors. Using this assay, association between the wheat Sr27 stem rust disease resistance protein and corresponding AvrSr27 avirulence effector family produced by the rust pathogen is detected. Interaction is also observed between this resistance protein and the effector encoded by the corresponding avrSr27‐3 virulence allele. However, this association appears weaker in the split GAL4 RUBY assay, which coupled with lower avrSr27‐3 expression during stem rust infection, likely enables virulent races of the rust pathogen to avoid Sr27‐mediated detection.
Topology Design and Optimization of Modular Soft Robots Capable of Homogenous and Heterogenous Reconfiguration
Authors: Freeman Caitlin , Conzola Justin , Vikas Vishesh
Published: April 2023

The deformability of soft material robots provides them with the ability to transform between complex shapes and forms. This unique ability facilitates Modular Soft Robots (MSoRos) to assemble and reconfigure into different configurations, e.g., planar and spherical. These topologies display widely different locomotion modes that are desirable to navigate different environments, e.g., crawling or rolling for these cases. This research presents topology design and optimization methodology of MSoRos capable of both homogeneous and heterogeneous reconfiguration in spherical and planar configurations. Homogeneous reconfiguration refers to the scenario when all the modules are identical, while the heterogeneous contains nonidentical modules. The sequential design approach uses a polyhedron (Archimedean or Platonic) as the base solid to define module characteristics. As the design processes involve nonlinear projections, the base polyhedron also dictates the type of reconfiguration—heterogeneous (Archimedean) or homogeneous (Platonic). Thereafter, it applies the polyhedron vertex alignment principle to ensure geometric alignment of the modules during reconfiguration. Planar and spherical distortion metrics are defined to quantify distortions due to reconfiguration. Subsequently, the optimal topology is obtained by minimizing a cost function that is a weighted sum of the two distortion metrics. The result is a set of MSoRos capable of distinct 1D and 2D planar configurations (both heterogeneous and homogeneous) and multiple 3D spherical configurations of varying radii (both heterogeneous and homogeneous). The methodology is validated on a MSoRo system based on the combination of a cuboctahedron (Archimedean solid) and a cube and an octahedron (Platonic solids).
Stability and Bifurcation Analysis of Precision Motion Stage With Nonlinear Friction Isolator
Authors: Gupta Sunit K. , Basta Ehab E. , Barry Oumar R.
Published: April 2023

The application of servocontrolled mechanical-bearing-based precision motion stages (MBMS) is well-established in advanced manufacturing, semiconductor industries, and metrological applications. Nevertheless, the performance of the motion stage is plagued by self-excited friction-induced vibrations. Recently, a passive mechanical friction isolator (FI) has been introduced to reduce the adverse impact of friction in MBMS, and accordingly, the dynamics of MBMS with FI were analyzed in the previous works. However, in the previous works, the nonlinear dynamics components of FI were not considered for the dynamical analysis of MBMS. This work presents a comprehensive, thorough analysis of an MBMS with a nonlinear FI. A servocontrolled MBMS with a nonlinear FI is modeled as a two DOF spring-mass-damper lumped parameter system. The linear stability analysis in the parametric space of reference velocity signal and differential gain reveals that including nonlinearity in FI significantly increases the local stability of the system's fixed-points. This further allows the implementation of larger differential gains in the servocontrolled motion stage. Furthermore, we perform a nonlinear analysis of the system and observe the existence of sub and supercritical Hopf bifurcation with or without any nonlinearity in the friction isolator. However, the region of sub and supercritical Hopf bifurcation on stability curves depends on the nonlinearity in FI. These observations are further verified by a detailed numerical bifurcation, which reveals the existence of nonlinear attractors in the system.
Bifurcation Analysis of Improved Traffic Flow Model on Curved Road
Authors: Ai WenHuan , Hu JiaDi , Liu DaWei
Published: April 2023

Nonlinear analysis of complex traffic flow systems can provide a deep understanding of the causes of various traffic phenomena and reduce traffic congestion, and bifurcation analysis is a powerful method for it. In this paper, based on the improved Aw–Rascle model, a new macroscopic traffic flow model is proposed, which takes into account the road factors and driver psychological factor in the curve environment which can effectively simulate many realistic traffic phenomena on curves. The macroscopic traffic flow model on curved road is analyzed by bifurcation, first, it is transformed into a nonlinear dynamical system, then its stability conditions and the existence conditions of bifurcations are derived, and the changes of trajectories near the equilibrium points are described by phase plane. From an equilibrium point, various bifurcation structures describing the nonlinear traffic flow are obtained. In this paper, the influence of different bifurcations on traffic flow is analyzed, and the causes of special traffic phenomena such as stop-and-go and traffic clustering are described using Hopf bifurcation as the starting point of density temporal evolution. The derivation and simulation show that both road factors and driver psychological factor affect the stability of traffic flow on curves, and the study of bifurcation in the curved traffic flow model provides decision support for traffic management.
Transforming the understanding of brain immunity
Authors: Castellani Giulia , Croese Tommaso , Peralta Ramos Javier M. , Schwartz Michal
Published: April 2023

Contemporary studies have completely changed the view of brain immunity from envisioning the brain as isolated and inaccessible to peripheral immune cells to an organ in close physical and functional communication with the immune system for its maintenance, function, and repair. Circulating immune cells reside in special niches in the brain’s borders, the choroid plexus, meninges, and perivascular spaces, from which they patrol and sense the brain in a remote manner. These niches, together with the meningeal lymphatic system and skull microchannels, provide multiple routes of interaction between the brain and the immune system, in addition to the blood vasculature. In this Review, we describe current ideas about brain immunity and their implications for brain aging, diseases, and immune-based therapeutic approaches.
Toward a vaccine against hepatitis C virus
Authors: Offersgaard Anna , Bukh Jens , Gottwein Judith M.
Published: April 2023

Recent advances aid the development of vaccines to prevent chronic liver diseases
Share all SARS-CoV-2 data immediately
Authors: Van Kerkhove Maria D.
Published: April 2023

When the first cases of human infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were reported from Wuhan, China, in December 2019, there was quick agreement across scientific and health communities that understanding the facts about its emergence would help prevent future outbreaks. Never could I have imagined the degree of politicization that would cloud this quest. Over the past 39 months, while reported deaths from COVID-19 increased to nearly 7 million worldwide, science on the virus’s origins has gotten smaller while the politics surrounding this question has grown ever bigger. Last month, the World Health Organization (WHO) learned that scientists in China possessed data on viral samples from Wuhan that had been gathered in January 2020, which should have been shared immediately—not 3 years later—with the global research community. The lack of data disclosure is simply inexcusable. The longer it takes to understand the origins of the pandemic, the harder it becomes to answer the question, and the more unsafe the world becomes.
From bad to worse
Authors: Kupferschmidt Kai
Published: April 2023

How the avian flu must change before it can trigger a human pandemic
Light sleeper? Eat more protein
Authors: Ferrarelli Leslie K.
Published: April 2023

A high-protein diet may promote deep sleep by gut secretion of a dopamine neuron–stimulating peptide.
Whole-Genome Sequence of Salmonella enterica Serovar Bispebjerg from Turkey Reveals Its Pathogenic Potential
Authors: Tiengo Alessia , Orsini Massimiliano , Petrin Sara , Losasso Carmen , Longo Alessandra , Cento Giulia , Ciot Laura , Ceruti Raffaella , Cibin Veronica , Barco Lisa
Published: April 2023

We report the genome sequence of a
Salmonella enterica
subsp.
enterica
serovar Bispebjerg strain that was isolated from a turkey flock in 2011. The genome analysis of the strain, a rare and multihost serovar, revealed its pathogenic potential due to antimicrobial resistance and a plethora of
Salmonella
pathogenicity islands and virulence factors.
Epstein-Barr Virus Envelope Glycoprotein gp110 Inhibits IKKi-Mediated Activation of NF-κB and Promotes the Degradation of β-Catenin
Authors: Guo Yingjie , Pan Lingxia , Wang Liding , Wang Shuai , Fu Jiangqin , Luo Wenqi , Wang Kezhen , Li Xiaoqing , Huang Chen , Liu Yintao , Kang Haoran , Zeng Qiyuan , Fu Xiuxia , Huang Zejin , Li Wanying , He Yingxin , Li Linhai , Peng Tao , Yang Haidi , Li Meili , Xiao Bin , Cai Mingsheng
Published: April 2023

Epstein-Barr virus (EBV) is a ubiquitous pathogen that infects almost all human beings, and the persistence of EBV in the host is largely due to immune escape mediated by its encoded products. Thus, elucidation of EBV’s immune escape mechanisms will provide a new direction for the design of novel antiviral strategies and vaccine development.
Combined Methylation and Transcriptome Analysis of Liver Injury of Nonalcoholic Fatty Liver Disease Induced by High Alcohol-Producing Klebsiella pneumoniae
Authors: Zhang Rui , Xu Ziying , Xue Guanhua , Feng Junxia , Du Bing , Gan Lin , Fan Zheng , Fu Tongtong , Feng Yanling , Zhao Hanqing , Cui Jinghua , Yan Chao , Cui Xiaohu , Tian Ziyan , Chen Jinfeng , Yu Zihui , Yuan Jing
Published: April 2023

High alcohol-producing
Klebsiella pneumoniae
(HiAlc
Kpn
) is one of causative agents of nonalcoholic fatty liver disease (NAFLD) and could induce liver damage. DNA methylation, as a common epigenetic form following contact with an etiologic agent and pathogenesis, can affect chromosome stability and transcription.
Supplemental Material: Two episodes of late Mesoproterozoic magmatism in the southwestern Yangtze block, China, and their association with Grenville-aged orogenic cycles
Authors: Wang Yan-Jun , zhu wei-guang , al. et
Published: April 2023

Figure S1: Representative field photos and microscopic photographs of mafic rocks in this study. Figure S2: Plot of whole-rock εNd(t) versus age (Ga) for the Boka dolerites, Lanniping gabbros, and Tong’an dikes. Figure S3: Covariations of the high field strength elements (e.g., TiO2, Th, Nb, Nd, Eu, Yb), compatible element (e.g., Ni), and large ion lithophile elements (e.g., Ba and Sr) relative to Zr contents for the Boka dolerites, Lanniping gabbros, and Tong’an dikes. Figure S4: Covariations of SiO2, TiO2, Fe2O3 T, CaO, Al2O3, CaO/Al2O3, P2O5, Ni, and Cr relative to MgO contents for the Boka dolerites, Lanniping gabbros, and Tong’an dikes. Figure S5: Th/Nb versus TiO2/Yb plot for the late Mesoproterozoic mafic rocks in the southwestern Yangtze block. Table S1: Cameca secondary ion mass spectrometry (SIMS) zircon and baddeleyite U-Pb isotopic analyses for late Mesoproterozoic mafic rocks from the Huili- Dongchuan area, southwestern Yangtze block. Table S2: Major-element (wt%) and trace element (ppm) data of the late Mesoproterozoic mafic rocks from the southwestern Yangtze block. Table S3: Sm-Nd isotopic compositions of the late Mesoproterozoic mafic rocks from the southwestern Yangtze block.
Predrawn prehospital medications are microbiologically safe for up to 48 hours
Authors: Soeyland Torgrim , Garner Alan , Vidler Sam , Gutierrez Cristian Humberto , Foster Arnold , Kitcher Jane
Published: April 2023

Background

Prehospital medical teams are commonly required to administer a range of medications for urgent stabilisation and treatment. The safe preparation of medications during resuscitation requires attention, time and resources, and can be a source of medication error. In our two road and HEMS (Helicopter Emergency Medical Service) prehospital services, medication errors are mitigated by predrawing commonly used medications to set concentrations daily (Hunter Retrieval Service, HRS) or second-daily (CareFlight Sydney, CFS). However, there are no published data confirming that such practice is microbiologically safe.

Methods

A convenience sample of 299 predrawn medication syringes with syringe dwell times up to 48 hours were collected at the end of their operational deployment. Predrawn medication syringes collected for culture were ketamine, midazolam, fentanyl, thiopentone, rocuronium, suxamethonium, metaraminol and normal saline. The samples were incubated and cultured at a tertiary hospital pathology laboratory using best-practice methodology for non-tissue samples. The samples were collected from June 2017 to February 2018.

Results

The mean dwell times ranged from 30.7 hours (fentanyl at HRS) to 48.5 hours (rocuronium at CFS). None of the 299 cultured samples yielded significant micro-organisms. One sample of suxamethonium with a syringe dwell time of 34 hours grewBacillus cereusbut was likely a contaminant introduced during sample collection.

Conclusion

Predrawing of the eight studied medications for urgent prehospital procedures appears to be a microbiologically safe practice with syringe dwell times up to 48 hours.
BET 1: Lenient or strict rate control for atrial fibrillation
Authors: Stratton Tara , Nasser Laila
Published: April 2023

A short cut review was carried out to establish whether the degree of rate control influences mortality in patients with atrial fibrillation. 22 papers presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are shown in the two tables. It is concluded that there is insufficient evidence to recommend any specific rate control target to decrease mortality in rate-controlled rapid atrial fibrillation.
Ventricular function and biomarkers in relation to repair and pulmonary valve replacement for tetralogy of Fallot
Authors: van der Ven Jelle P G , Günthel Marie , van den Bosch Eva , Kamphuis Vivian P , Blom Nicolaas A , Breur Johannes , Berger Rolf M F , Bogers Ad J J C , Koopman Laurens , Ten Harkel Arend D J , Christoffels Vincent , Helbing Willem A
Published: April 2023

Objective

Cardiac surgery may cause temporarily impaired ventricular performance and myocardial injury. We aim to characterise the response to perioperative injury for patients undergoing repair or pulmonary valve replacement (PVR) for tetralogy of Fallot (ToF).

Methods

We enrolled children undergoing ToF repair or PVR from four tertiary centres in a prospective observational study. Assessment—including blood sampling and speckle tracking echocardiography—occurred before surgery (T1), at the first follow-up (T2) and 1 year after the procedures (T3). Ninety-two serum biomarkers were expressed as principal components to reduce multiple statistical testing. RNA Sequencing was performed on right ventricular (RV) outflow tract samples.

Results

We included 45 patients with ToF repair aged 4.3 (3.4 – 6.5) months and 16 patients with PVR aged 10.4 (7.8 – 12.7) years. Ventricular function following ToF repair showed a fall-and-rise pattern for left ventricular global longitudinal strain (GLS) (−18±4 to −13±4 to −20±2, p < 0.001 for each comparison) and RV GLS (−19±5 to −14±4 to 20±4, p < 0.002 for each comparison). This pattern was not seen for patients undergoing PVR. Serum biomarkers were expressed as three principal components. These phenotypes are related to: (1) surgery type, (2) uncorrected ToF and (3) early postoperative status. Principal component 3 scores were increased at T2. This increase was higher for ToF repair than PVR. The transcriptomes of RV outflow tract tissue are related to patients’ sex, rather than ToF-related phenotypes in a subset of the study population.

Conclusions

The response to perioperative injury following ToF repair and PVR is characterised by specific functional and immunological responses. However, we did not identify factors relating to (dis)advantageous recovery from perioperative injury.

Trial registration number

Netherlands Trial Register: NL5129.
Observation of time-dependent internal charge amplification in a planar germanium detector at cryogenic temperature
Authors: Acharya P. , Fritts M. , Mei D.-M. , Mandic V. , Wang C.-J. , Mahapatra R. , Platt M.
Published: April 2023

For the first time, time-dependent internal charge amplification through impact ionization has been observed in a planar germanium (Ge) detector operated at cryogenic temperature. In a time period of 30 and 45 min after applying a bias voltage, the charge energy corresponding to a baseline of the 59.54 keV $$\gamma $$
γ
rays from a $$^{241}$$

241

Am source is amplified for a short period of time and then decreases back to the baseline. The amplification of charge energy depends strongly on the applied positive bias voltage with drifting holes across the detector. No such phenomenon is visible with drifting electrons across the detector. We find that the observed charge amplification is dictated by the impact ionization of charged states, which has a strong correlation with impurity level and applied electric field. We analyze the dominant physics mechanisms that are responsible for the creation and the impact ionization of charged states. Our analysis suggests that the appropriate level of impurity in a Ge detector can enhance charge yield through the impact ionization of charged states to achieve extremely low-energy detection threshold (< 10 meV) for MeV-scale dark matter searches if the charge amplification can be stabilized.
Opportunity Cost and Missed Chances in Optimizing Cybersecurity
Authors: Shortridge Kelly , Dykstra Josiah
Published: April 2023

Opportunity cost should not be an afterthought when making security decisions. One way to ease into considering complex alternatives is to consider the null baseline of doing nothing instead of the choice at hand. Opportunity cost can feel abstract, elusive, and imprecise, but it can be understood by everyone, given the right introduction and framing. Using the approach presented here will make it natural and accessible.
Ultra-Fine Maghemite (γ-Fe2O3) Nanoparticles Anchored on 3D Reduced Graphene Oxide Aerogels for Advanced Lithium-Ion Battery Anodes
Authors: Cao Da , Yang Yi , Lu Junhong , Zhu Ye , He Dafang , He Guangyu
Published: April 2023

Fe2O3 has been widely investigated as anode material for its high theoretical capacity and natural abundance, but the low conductivity, large volume variation and slow kinetics seriously hinder its commercialization. Here, we propose the in situ growth of ultra-fine Maghemite (γ-Fe2O3) NPs on the 3D rGO aerogel with abundant pores by a facile freeze-drying process followed by thermal annealing, which is confirmed by XRD and HR-TEM. This novel 3D porous structure ensures fast electron and ion diffusion within the electrode, which effectively mitigates the volume expansion of Fe2O3 during cycling. Benefiting from these advantages, an excellent cycling performance of 668 mAh g−1 at 0.5 A g−1 over 100 cycles as well as outstanding rate performance are achieved. These results provide a promising approach of advanced anode materials for Lithium-ion batteries.
A Systemic Investigation on the Sensing Behaviors for Dopamine Based on the Combination of Cu-MOF and Various Carbon Materials
Authors: Zhang Jing , Liu Lu , Zhuang Xiaoli , Meng Wei , Ren Dongmei , Wang Yue , Tong Boran , Han Chao
Published: April 2023

Two-phase composites of Cu-MOF/X (X = multi-walled carbon nanotube (MWNT), graphene, poly (3,4-ethylenedioxythiophene) (PEDOT), acetylene black (AB)) were constructed and used as electrode materials for dopamine (DA) sensing in this work, respectively. The sensing performances of these modified electrode based on different carbon materials were systematically investigated. The DPV analysis data showed that compared with naked GCE and Cu-MOF/GCE, Cu-MOF/X/GCE (X = MWNT, graphene, PEDOT, AB) showed good electrocatalytic activity and DA oxidation sensing behavior because of the good conductivity of carbon materials. Moreover, the systematical investigation of sensing performances based on each modified electrode showed that: on the one hand, the sensing behaviors of each modified electrode were greatly influenced by the content of carbon material; on this other hand, the modified electrode based on different carbon material all exhibited different sensing behaviors. Cu-MOF/MWNT/GCE showed the best performance in the range of DA concentration from 0.5 to 200 μM, and the maximum sensitivity was 0.252 μA·μm−1. In addition, the selectivity, reproducibility and stability of Cu-MOF/X/GCE (X = MWNT, graphene, PEDOT, AB) were all carried out.
Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group
Authors: Santos-García Diego , de Deus Fonticoba Teresa , Cores Bartolomé Carlos , Feal Painceiras Maria J. , Íñiguez-Alvarado Maria Cristina , Jesús Silvia , Buongiorno Maria Teresa , Planellas Lluís , Cosgaya Marina , García Caldentey Juan , Caballol Nuria , Legarda Ines , Hernández Vara Jorge , Cabo Iria , López Manzanares Lydia , González Aramburu Isabel , Ávila Rivera Maria A. , Gómez Mayordomo Víctor , Nogueira Víctor , Puente Víctor , Dotor García-Soto Julio , Borrué Carmen , Solano Vila Berta , Álvarez Sauco María , Vela Lydia , Escalante Sonia , Cubo Esther , Carrillo Padilla Francisco , Martínez Castrillo Juan C. , Sánchez Alonso Pilar , Alonso Losada Maria G. , López Ariztegui Nuria , Gastón Itziar , Kulisevsky Jaime , Blázquez Estrada Marta , Seijo Manuel , Rúiz Martínez Javier , Valero Caridad , Kurtis Mónica , de Fábregues Oriol , González Ardura Jessica , Alonso Redondo Ruben , Ordás Carlos , López Díaz Luis M. L. , McAfee Darrian , Martinez-Martin Pablo , Mir Pablo , COPPADIS Study Group
Published: April 2023

Introduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year ± 15 days), and V2 for patients and at V0 and V2 for controls. Results. The frequency of drooling in PD patients was 40.1% (277/691) at V0 (2.4% (5/201) in controls;

p

 < 0.0001), 43.7% (264/604) at V1, and 48.2% (242/502) at V2 (3.2% (4/124) in controls;

p

 < 0.0001), with a period prevalence of 63.6% (306/481). Being older (OR = 1.032;

p

 = 0.012), being male (OR = 2.333;

p

 < 0.0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR = 1.020;

p

 < 0.0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR = 1.012;

p

 < 0.0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with ≤2 years since symptom onset, with a cumulative prevalence of 64.6% and a higher score on the UPDRS-III at V0 (OR = 1.121;

p

 = 0.007) as a predictor of drooling at V2. Conclusion. Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden.
Hyperspectral Compressed Sensing Reconstruction Applying Multi‐TV Collaboration
Authors: Xiao Hua , Wang Zhongliang , Cui Xueying , Wang Liping , Yang Hongsheng
Published: April 2023

For hyperspectral images (HSI) compressed sensing reconstruction, the 3D total variation (3DTV) is a powerful regulation term encoding the spatial‐spectral local smooth prior structure. The term is calculated by supposing the sparsity structure on a gradient map along the spatial and spectral direction. In some real scenes, however, the gradient maps along different directions of HSI are not always sparse. Actually, TV constraints established on the gradient map of the original HSI are more effective in most cases. In this paper, instead of imposing sparsity on gradient maps themselves directly, compressed sensing (CS) reconstruction for HSI is formulated as an optimization problem utilizing a novel regulation term named multi‐TV (MTV), which combines the sparsity prior for the gradient map and the TV projection along with other directions of the gradient map. We also develop a workable utility algorithm based on the alternating direction method of multipliers (ADMM) to effectively deal with the optimization problem. The proposed MTV term can easily replace the conventional 3DTV term and be embedded into hyperspectral CS (HCS) reconstruction to improve its performance. Experimental results show that compared with similar state‐of‐the‐art methods, the proposed MTV term can significantly improve reconstruction precision for HCS.
Spontaneous Imbibition Experiment and Main Influence Factors in Ultra-Low-Permeability Reservoirs
Authors: Shi Lihua , Li Hong , Shi Tiaotiao , Hou Binchi , Xue Ying , Shen Zhenzhen , Zeng Jun
Published: April 2023

The imbibition has an important influence on the water injection development of ultra-low-permeability reservoirs. In this paper, the nuclear magnetic resonance (NMR) high-temperature and high-pressure displacement system was used to simulate the formation temperature and pressure and the spontaneous imbibition of single porosity medium and dual porosity medium (containing fractures), and imbibition displacement experiments at different injection rates were carried out. The NMR T2 spectrum curves of simulated oil signals in the pores, throats, and fractures were obtained. The characteristics of oil content change and oil displacement efficiency in dual porosity medium under different experimental conditions were quantitatively evaluated, and the contribution of spontaneous imbibition to oil displacement efficiency was clarified. The experimental results show that the oil displacement efficiency of single porosity medium is lower than that of dual porosity medium. The smaller the pore is, the greater the displacement speed is, and the greater the contribution rate of imbibition is. The porosity, permeability, and maximum pore throat radius are positively correlated with the oil displacement efficiency of spontaneous imbibition but are poorly correlated with the oil displacement efficiency of under the dual action of spontaneous imbibition and displacement. The poor correlation also includes the median pressure, maximum mercury saturation, median radius, and displacement rate. Fractures play a positive role in improving oil displacement efficiency.
Study on the Hyperglycemic Effect of GLP-1 in Spinibarbus denticulatus by Oral Administration and Intraperitoneal Injection Methods
Authors: Luo Wei , Li Luojia , Zhang Yue , Xu Zhou , Xiong Yinlin , Guo Zhonggang , Zhang Ning , Zhang Yibo , Chen Pengyu , Wang Yan , Du Zongjun
Published: April 2023

Glucagon-like peptide-1 (GLP-1), one of the expression products of the proglucagon (pg) gene, is an incretin mainly secreted by the gastrointestinal system. In mammals, GLP-1 has hypoglycemic and food-inhibiting effects; while in some fish species, it has been confirmed to increase blood glucose by promoting gluconeogenesis and stimulating glycogenolysis. In order to more deeply understand the role of GLP-1 in the process of glycometabolism in herbivorous fish, the pg gene was cloned from Spinibarbus denticulatus to obtain its sequence characteristics, and the changes in blood glucose level and pg gene expression in S. denticulatus were further explored by feeding with three kinds of carbohydrates and intraperitoneal injection of GLP-1. Basal and temporal blood glucose levels and pg gene expression of S. denticulatus (

91.68
±
10.79
 
g

) were measured at 0, 1, 3, 5, 7, and 12 h after oral administration (

n
=
4

). Then, the changes of blood glucose levels and pg and glucokinase (gk) gene expressions of S. denticulatus (

94.29
±
10.82
 
g

) were determined at 0, 30, 60, and 120 min after intraperitoneal injection (

n
=
4

). It was shown that polysaccharides could induce the upregulation of pg gene expression faster than monosaccharides and stimulate the secretion of GLP-1 in the intestine. Intraperitoneal injection of GLP-1 peptide rapidly raised blood glucose levels, and pg gene expression in the anterior intestine, whole brain, and hepatopancreas decreased continuously after 30 minutes. These results showed that S. denticulatus might inhibit the excessive accumulation of blood glucose by reducing the expression of the pg gene and increasing the expression of gk gene in a short time. It was speculated that GLP-1 of S. denticulatus might have a “gut-brain-liver” pathway similar to mammals in glycemia regulation. Therefore, this study provided a novel perspective for explaining the functional differences of GLP-1 in herbivorous fish and mammals.
Supplementary Table S3 from Antisense RNAs Influence Promoter Usage of Their Counterpart Sense Genes in Cancer
Authors: Bellido Molias Fernando , Sim Andre , Leong Ka Wai , An Omer , Song Yangyang , Ng Vanessa Hui En , Lim Max Wei Jie , Ying Chen , Teo Jasmin Xin Jia , Göke Jonathan , Chen Leilei
Published: April 2023

List of ncNATs expressed in TCGA and GTEx non-tumor samples, for which their associated sense genes have two active alternative promoters
TableS2 from Modeling High-Grade Serous Ovarian Carcinoma Using a Combination of In Vivo Fallopian Tube Electroporation and CRISPR-Cas9–Mediated Genome Editing
Authors: Teng Katie , Ford Matthew J. , Harwalkar Keerthana , Li YuQi , Pacis Alain S. , Farnell David , Yamanaka Nobuko , Wang Yu-Chang , Badescu Dunarel , Ton Nu Tuyet Nhung , Ragoussis Jiannis , Huntsman David G. , Arseneau Jocelyne , Yamanaka Yojiro
Published: April 2023

Supplementary Table2
Table ST3 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

Table ST3: Differential expressed RNA transcripts between MEKi-sensitive and -resistant melanoma cell cultures.
Supplementary Data from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

Tumor Profiler Consortium author list
Suppl. Figure S7 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S7: Pathway enrichment (metabolomics)
Suppl. Figure S12 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S12: Analysis of CyTof data from fresh melanoma tissue
Suppl. Figure S10 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S10: Clinical data of orthologic slice cultures
Supplementary Table S3 from CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer
Authors: Faraoni Erika Y. , Singh Kanchan , Chandra Vidhi , Le Roux Olivereen , Dai Yulin , Sahin Ismet , O'Brien Baylee J. , Strickland Lincoln N. , Li Le , Vucic Emily , Warner Amanda N. , Pruski Melissa , Clark Trent , Van Buren George , Thosani Nirav C. , Bynon John S. , Wray Curtis J. , Bar-Sagi Dafna , Poulsen Kyle L. , Vornik Lana A. , Savage Michelle I. , Sei Shizuko , Mohammed Altaf , Zhao Zhongming , Brown Powel H. , Mills Tingting , Eltzschig Holger K. , McAllister Florencia , Bailey-Lundberg Jennifer M.
Published: April 2023

Table S3
Supplementary Data from WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth
Authors: Wang Keshan , Ma Fen , Arai Seiji , Wang Yun , Varkaris Andreas , Poluben Larysa , Voznesensky Olga , Xie Fang , Zhang Xiaoping , Yuan Xin , Balk Steven P.
Published: April 2023

Figures S1 - S6
Supplementary Data from Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer
Authors: Jagadeeshan Sankar , Prasad Manu , Badarni Mai , Ben-Lulu Talal , Liju Vijayasteltar Belsamma , Mathukkada Sooraj , Saunders Claire , Shnerb Avital Beeri , Zorea Jonathan , Yegodayev Ksenia M. , Wainer Monica , Vtorov Liza , Allon Irit , Cohen Ofir , Gausdal Gro , Friedmann-Morvinski Dinorah , Cheong Sok Ching , Ho Alan L. , Rosenberg Ari J. , Kessler Linda , Burrows Francis , Kong Dexin , Grandis Jennifer R. , Gutkind J. Silvio , Elkabets Moshe
Published: April 2023

Supplementary Materials and Methods
Supplementary Table S8 from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma
Authors: Zhao Mengjie , Li Yanhui , Lu Chenfei , Ding Fangshu , Xu Miao , Ge Xin , Li Mengdie , Wang Zhen , Yin Jianxing , Zhang Junxia , Wang Xiefeng , Ge Zehe , Xiao Hong , Xiao Yong , Liu Hongyi , Liu Wentao , Cao Yuandong , Wang Qianghu , You Yongping , Wang Xiuxing , Yang Kun , Shi Zhumei , Qian Xu
Published: April 2023

Table S8. IHC scores of 95 GBM samples
Supplementary Table S6 from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma
Authors: Zhao Mengjie , Li Yanhui , Lu Chenfei , Ding Fangshu , Xu Miao , Ge Xin , Li Mengdie , Wang Zhen , Yin Jianxing , Zhang Junxia , Wang Xiefeng , Ge Zehe , Xiao Hong , Xiao Yong , Liu Hongyi , Liu Wentao , Cao Yuandong , Wang Qianghu , You Yongping , Wang Xiuxing , Yang Kun , Shi Zhumei , Qian Xu
Published: April 2023

Table S6. Cox regression analysis in CGGA GBM patients
Supplementary Table S2 from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma
Authors: Zhao Mengjie , Li Yanhui , Lu Chenfei , Ding Fangshu , Xu Miao , Ge Xin , Li Mengdie , Wang Zhen , Yin Jianxing , Zhang Junxia , Wang Xiefeng , Ge Zehe , Xiao Hong , Xiao Yong , Liu Hongyi , Liu Wentao , Cao Yuandong , Wang Qianghu , You Yongping , Wang Xiuxing , Yang Kun , Shi Zhumei , Qian Xu
Published: April 2023

Table S2. Logistic regression analysis from GLASS database
Supplementary Table S1 from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma
Authors: Zhao Mengjie , Li Yanhui , Lu Chenfei , Ding Fangshu , Xu Miao , Ge Xin , Li Mengdie , Wang Zhen , Yin Jianxing , Zhang Junxia , Wang Xiefeng , Ge Zehe , Xiao Hong , Xiao Yong , Liu Hongyi , Liu Wentao , Cao Yuandong , Wang Qianghu , You Yongping , Wang Xiuxing , Yang Kun , Shi Zhumei , Qian Xu
Published: April 2023

Table S1. Oligos used in this study
S8 from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis
Authors: Anstine Lindsey J. , Majmudar Parth R. , Aponte Amy , Singh Salendra , Zhao Ran , Weber-Bonk Kristen L. , Abdul-Karim Fadi W. , Valentine Mitchell , Seachrist Darcie D. , Grennel-Nickelson Katelyn E. , Cuellar-Vite Leslie , Sizemore Gina M. , Sizemore Steven T. , Webb Bryan M. , Thompson Cheryl L. , Keri Ruth A.
Published: April 2023

Supplemental Figure 8
S6 from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis
Authors: Anstine Lindsey J. , Majmudar Parth R. , Aponte Amy , Singh Salendra , Zhao Ran , Weber-Bonk Kristen L. , Abdul-Karim Fadi W. , Valentine Mitchell , Seachrist Darcie D. , Grennel-Nickelson Katelyn E. , Cuellar-Vite Leslie , Sizemore Gina M. , Sizemore Steven T. , Webb Bryan M. , Thompson Cheryl L. , Keri Ruth A.
Published: April 2023

Supplemental Figure 6
S6 Legend from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis
Authors: Anstine Lindsey J. , Majmudar Parth R. , Aponte Amy , Singh Salendra , Zhao Ran , Weber-Bonk Kristen L. , Abdul-Karim Fadi W. , Valentine Mitchell , Seachrist Darcie D. , Grennel-Nickelson Katelyn E. , Cuellar-Vite Leslie , Sizemore Gina M. , Sizemore Steven T. , Webb Bryan M. , Thompson Cheryl L. , Keri Ruth A.
Published: April 2023

Supplemental Figure 6 Legend
S5 from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis
Authors: Anstine Lindsey J. , Majmudar Parth R. , Aponte Amy , Singh Salendra , Zhao Ran , Weber-Bonk Kristen L. , Abdul-Karim Fadi W. , Valentine Mitchell , Seachrist Darcie D. , Grennel-Nickelson Katelyn E. , Cuellar-Vite Leslie , Sizemore Gina M. , Sizemore Steven T. , Webb Bryan M. , Thompson Cheryl L. , Keri Ruth A.
Published: April 2023

Supplemental Figure 5
S3 Legend from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis
Authors: Anstine Lindsey J. , Majmudar Parth R. , Aponte Amy , Singh Salendra , Zhao Ran , Weber-Bonk Kristen L. , Abdul-Karim Fadi W. , Valentine Mitchell , Seachrist Darcie D. , Grennel-Nickelson Katelyn E. , Cuellar-Vite Leslie , Sizemore Gina M. , Sizemore Steven T. , Webb Bryan M. , Thompson Cheryl L. , Keri Ruth A.
Published: April 2023

Supplemental Figure 3 Legend
Supplementary Figures and Figure LegendsSupplementary Figures and Figure Legends from USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
Authors: Ren Yidan , Feng Maoxiao , Hao Xiaodong , Liu Xiaoyan , Li Juan , Li Peilong , Gao Jie , Qi Qiuchen , Du Lutao , Wang Chuanxin , Wang Qin , Wang Yunshan
Published: April 2023

Supplementary figures and figure Legends
Original Image of western blot from USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
Authors: Ren Yidan , Feng Maoxiao , Hao Xiaodong , Liu Xiaoyan , Li Juan , Li Peilong , Gao Jie , Qi Qiuchen , Du Lutao , Wang Chuanxin , Wang Qin , Wang Yunshan
Published: April 2023

Original Image of western blot
Data from FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1
Authors: Kwon Mijung , Rubio Genesaret , Nolan Nicholas , Auteri Peter , Volmar Jean Arly , Adem Asha , Javidian Parisa , Zhou Zhongren , Verzi Michael P. , Pine Sharon R. , Libutti Steven K.
Published: April 2023

Abstract
Aneuploid mucinous colorectal adenocarcinoma (MAC) is an aggressive subtype of colorectal cancer with poor prognosis. The tumorigenic mechanisms in aneuploid MAC are currently unknown. Here we show that downregulation of Filamin A–interacting protein 1-like (FILIP1L) is a driver of MAC. Loss of FILIP1L increased xenograft growth, and, in colon-specific knockout mice, induced colonic epithelial hyperplasia and mucin secretion. The molecular chaperone prefoldin 1 (PFDN1) was identified as a novel binding partner of FILIP1L at the centrosomes throughout mitosis. FILIP1L was required for proper centrosomal localization of PFDN1 and regulated proteasome-dependent degradation of PFDN1. Importantly, increased PFDN1, caused by downregulation of FILIP1L, drove multinucleation and cytokinesis defects in vitro and in vivo, which were confirmed by time-lapse imaging and 3D cultures of normal epithelial cells. Overall, these findings suggest that downregulation of FILIP1L and subsequent upregulation of PFDN1 is a driver of the unique neoplastic characteristics in aggressive aneuploid MAC.
Significance:
This study identifies FILIP1L as a tumor suppressor in mucinous colon cancer and demonstrates that FILIP1L loss results in aberrant stabilization of a centrosome-associated chaperone protein to drive aneuploidy and disease progression.
Figure S5D from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 5D presents the funnel plots from the meta-analysis of adiponectin and breast cancer risk
Figure S5A from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 5A presents the forest plots for adiponectin and breast cancer risk, by menopausal status
Figure S1D from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 1D presents dose-response curves for CRP and breast cancer risk, by menopausal status
Figure S1 from High-Throughput Peptide Arrays Identify Potential Diagnostic Autoantibody Signatures in Early-Stage Lung Adenocarcinoma
Authors: Luo Rongrong , Zhong Pei , Li Xiying , Cai Juan , Tao Yimin , Xiong Bangzhu , Zheng Hancheng , Zhang Zhishang , Tang Le , Yao Jiarui , Li Yingrui , Shi Yuankai , Han Xiaohong
Published: April 2023

Reproducibility of peptides microarray. a, Heatmap of spearman correlation of 47 samples tested with 3 technical repeats within one batch. b. Heatmap of spearman correlation of 6 samples repeatedly tested across 3 batches.
Table S4 from Deep Transcriptome Profiling of Multiple Myeloma Using Quantitative Phenotypes
Authors: Griffin Rosalie , Hanson Heidi A. , Avery Brian J. , Madsen Michael J. , Sborov Douglas W. , Camp Nicola J.
Published: April 2023

Hazard ratios of high vs low risk early treatment failure.