bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathophysiology and management of sensitive skin: position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch (IFSI)
Authors: Misery L. , Weisshaar E. , Brenaut E. , Evers A.W.M. , Huet F. , Ständer S. , Reich A. , Berardesca E. , Serra‐Baldrich E. , Wallengren J. , Linder D. , Fluhr J.W. , Szepietowski J.C. , Maibach H. ,   for the Special Interest Group on sensitive skin of the International Forum for the Study of Itch (ISFI)
Published: October 2019

The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations of the skin nervous system. Skin barrier abnormalities are frequently associated, but there is no cause and direct relationship. Further studies are needed to better understand the pathophysiology of sensitive skin – as well as the inducing factors. Avoidance of possible triggering factors and the use of well‐tolerated cosmetics, especially those containing inhibitors of unpleasant sensations, might be suggested for patients with sensitive skin. The role of psychosocial factors, such as stress or negative expectations, might be relevant for subgroups of patients. To date, there is no clinical trial supporting the use of topical or systemic drugs in sensitive skin. The published data are not sufficient to reach a consensus on sensitive skin management. In general, patients with sensitive skin require a personalized approach, taking into account various biomedical, neural and psychosocial factors affecting sensitive skin.
Black Nursing Home Residents More Likely to Watch Advance Care Planning Video
Authors: Loomer Lacey , Volandes Angelo E. , Mitchell Susan L. , Belanger Emmanuelle , McCreedy Ellen , Palmer Jennifer A. , Mor Vincent
Published: October 2019

BACKGROUND/OBJECTIVES

This study aims to identify resident characteristics associated with being offered and subsequently shown an advance care planning (ACP) video in the Pragmatic Trial of Video Education in Nursing Homes (PROVEN) and if differences are driven by within‐ and/or between‐facility differences.

DESIGN

Cross‐sectional study, from March 1, 2016, to May 31, 2018.

SETTING

A total of 119 PROVEN intervention nursing homes (NHs).

PARTICIPANTS

A total of 43 303 new NH admissions.

MEASUREMENTS

Data came from the Minimum Data Set and an electronic record documenting whether a video was offered and shown to residents. We conduct both naïve logistic regression models and hierarchical logistic models, controlling for NH fixed effects, to examine the overall differences in offer and show rate by resident characteristics.

RESULTS

In naïve regression models, compared to white residents, black residents are 7.8 percentage point (pp) (95% confidence interval [CI] = −9.1 to −6.5 pp) less likely to be offered the video. These differences decrease to 1.3 pp (95% CI = −2.61 to −0.02 pp) when accounting for NH fixed effects. In fully adjusted models, black residents compared to white residents were 2.1 pp more likely to watch the video contingent on being offered (95% CI = 0.4‐3.7 pp). Residents with cognitive impairment were less likely to be offered and shown the video.

CONCLUSIONS

After controlling for NH fixed effects, there were smaller racial differences in being offered the video, but once offered, black residents were more likely to watch the video. This suggests that black residents are receptive to this type of ACP intervention but need to be given an opportunity to be exposed. J Am Geriatr Soc 68:603–608, 2020
The safety and tolerability of Annona muricata leaf extract: a systematic review
Authors: Chan Wai-Jo Jocelin , McLachlan Andrew J , Hanrahan Jane R , Harnett Joanna E
Published: October 2019

Objectives

Annona muricata, also known as graviola, soursop and guanabana, has been widely utilised for the treatment of a range of cancers. The mechanism of action and the efficacy of A. muricata and its constituents in the treatment of cancer have been comprehensively reviewed. The aim of this systematic review was to summarise the available literature that reports on factors related to the safety and tolerability of A. muricata leaf extract and its acetogenins.

Methods

In-vitro, preclinical animal studies and human studies of any design written in any language were included. Studies that evaluated A. muricata leaf extract and its constituents were searched through the databases Pubmed, Medline and Embase from inception to April 2019. The elaborated item 4 of Consolidated Standards of Reporting Trials statement and Animals in Research: Reporting In vivo Experiments guidelines were used to evaluate the quality of the studies.

Key findings

The results suggest that A. muricata and its constituents have hepatoprotective, neurotoxic, antinociceptive, anti-ulcerative and chemopreventive effects. The dose and duration used in animal studies demonstrating toxicity may not directly translate into the effects in humans. Studies included in this review were judged to be of medium to high quality.

Conclusions

The overall outcome of the current review suggests that A. muricata has a favourable safety and tolerability profile. Future studies investigating its use in people diagnosed with a range of cancers are warranted.
Pharmacokinetics of subcutaneously administered doramectin in alpacas
Authors: Lye Gordon , Jacob Anthony , Pomroy William , Stafford Kevin , Singh Preet
Published: October 2019

The objective of this research was to evaluate comparative pharmacokinetics of doramectin in alpacas, after subcutaneous administration of 0.2 mg/kg dose. Six healthy adult alpacas, mean age of 5 years ± 1, (three female and three gelded males) of mean bodyweight of 62 kg ± 16 kg with an average body condition scored 2.8 ± 1 out of five, were used in this study. Serial blood samples were collected from the jugular vein before the administration until day 21 afterwards to establish the pharmacokinetics of doramectin after its subcutaneous administration at 0.2 mg/kg dose. The blood samples were analysed using high‐performance liquid chromatography (HPLC), fluorescence detection method with precolumn derivatisation, validated for alpacas. The pharmacokinetic parameters were calculated using a noncompartmental model, and results showed Cmax (6.05 ± 5.34 ng/ml), Tmax (3.83 ± 2.48 days), AUC (62.12 ± 18.86 ng/ml × d), terminal half‐life (6.2 ± 4.9 days) and MRT (11.56 ± 4.43 days). The results of this study showed that the Cmax and AUC were much lower than in cattle and sheep at the same dosage. Tmax remained similar to cattle and sheep. This study presents valuable information about pharmacokinetics of doramectin in alpacas, which can be utilised in its future efficacy studies.
Variation in field body temperature and total evaporative water loss along an environmental gradient in a diurnal ectotherm
Authors: Sannolo M. , Civantos E. , Martín J. , Carretero M.A.
Published: October 2019

The maintenance of optimal body temperatures has profound consequences on all aspects of ectotherms life history, like fitness and performance, and has been the subject of research for decades. In contrast, for reptiles, comparatively less is known on the potential effects of water balance on physiology, ecology and behaviour. In recent years, several recent studies are pointing out the importance of studying thermoregulation and water balance within the same framework. Here, we used a Mediterranean lizard, Psammodromus algirus, to investigate how field body temperature and water loss rates may vary among populations, between sexes and along an altitudinal gradient. We found little variation in field body temperatures among populations, while within each population, field body temperature may change daily, seasonally and differ between sexes. On the contrary, water loss rates decreased with elevation and showed no seasonal trend or difference between sexes. Microclimatic data indicated that highland lizards experienced more fluctuating conditions, a factor that may explain their lower water loss rates. Other factors, like inter‐population differences in ectoparasite intensity, might also contribute in explaining the observed patterns. We present here the first data for a lacertid lizard on the inter‐population variability and sexual difference in water loss rates and point out that water balance may play a fundamental role in regulating lizard activity during the hottest and driest period of the year.
The group A Streptococcus accessory protein RocA: regulatory activity, interacting partners and influence on disease potential
Authors: Jain Ira , Danger Jessica L. , Burgess Cameron , Uppal Timsy , Sumby Paul
Published: October 2019

The group A Streptococcus (GAS) causes diseases that range from mild (e.g. pharyngitis) to severely invasive (e.g. necrotizing fasciitis). Strain‐ and serotype‐specific differences influence the ability of isolates to cause individual diseases. At the center of this variability is the CovR/S two‐component system and the accessory protein RocA. Through incompletely defined mechanisms, CovR/S and RocA repress the expression of more than a dozen immunomodulatory virulence factors. Alleviation of this repression is selected for during invasive infections, leading to the recovery of covR, covS or rocA mutant strains. Here, we investigated how RocA promotes CovR/S activity, identifying that RocA is a pseudokinase that interacts with CovS. Disruption of CovS kinase or phosphatase activities abolishes RocA function, consistent with RocA acting through the modulation of CovS activity. We also identified, in conflict with a previous study, that the RocA regulon includes the secreted protease‐encoding gene speB. Finally, we discovered an inverse correlation between the virulence of wild‐type, rocA mutant, covS mutant and covR mutant strains during invasive infection and their fitness in an ex vivo upper respiratory tract model. Our data inform on mechanisms that control GAS disease potential and provide an explanation for observed strain‐ and serotype‐specific variability in RocA function.
Arrestin‐independent constitutive endocytosis of GPR125/ADGRA3
Authors: Spiess Katja , Bagger Sofie O. , Torz Lola J. , Jensen Kristian H. R. , Walser Anna L. , Kvam Jone M. , Møgelmose Ann‐Sofie K. , Daugvilaite Viktorija , Junnila Riia K. , Hjortø Gertrud M. , Rosenkilde Mette M.
Published: October 2019

The orphan receptor GPR125 (ADGRA3) belongs to subgroup III of the adhesion G protein−coupled receptor (aGPCR) family. aGPCRs, also known as class B2 GPCRs, share basic structural and functional properties with other GPCRs. Many of them couple to G proteins and activate G protein−dependent and −independent signaling pathways, but little is known about aGPCR internalization and β‐arrestin recruitment. GPR125 was originally described as a spermatogonial stem cell marker and studied for its role in Wnt signaling and cell polarity. Here, using cell‐based assays and confocal microscopy, we show that GPR125 is expressed on the cell surface and undergoes constitutive endocytosis in a β‐arrestin−independent, but clathrin‐dependent manner, as indicated by colocalization with transferrin receptor 1, an early endosome marker. These data support that the constitutive internalization of GPR125 contributes to its biological functions by controlling receptor surface expression and accessibility for ligands. Our study sheds light on a new property of aGPCRs, namely internalization; a property described to be important for signal propagation, signal termination, and desensitization of class A (rhodopsin‐like) and B1 (VIP/secretin) GPCRs.
Falling Film Evaporation of HFO-1233zd(E) in Vertical Rectangular Minichannels Consisting of Serrated-Fins
Authors: Ohara Junichi
Published: October 2019

In the present study, the characteristics of heat transfer are experimentally investigated on the falling film evaporation of alternative pure refrigerant HFO-1233zd(E) in a plate-fin heat exchanger having a vertical rectangular minichannels of 2.11 mm hydraulic diameter consisting of serrated-fins. The refrigerant liquid is supplied to the channel through 37 holes of a liquid distributor. The liquid flowing down vertically is heated electrically from the rear wall of the channel and evaporated. The experimental parameters are as follows: the mass velocities are varied 7.4∼55.1 [kg/(m2s)], the heat fluxes are varied 8.7∼50 [kW/m2] and the pressures are about 100 [kPa].

In the case of small mass velocity being smaller than 20 [kg/(m2s)], heat transfer coefficient decreases monotonously and gradually with increase of quality and take value of 5∼1[kW/m2K]. It is thought that the cause of lower value of heat transfer coefficient is occurring dry patch and aria enlargement of dry area in the downstream region. In the case of large mass velocity being larger than 41 [kg/(m2s)], the value of heat transfer coefficient becomes larger with increase of quality except for the case of mass velocity being 41 [kg/(m2s)] and heat flux being 50[kW/m2]. Improved heat transfer is to be thinkable that the liquid and vapor flow becomes dripping in the middle-stream region, and turns into mist flow with thin liquid film on the fin surface in the downstream region of quality being larger than 0.4.
Optimization of Hybrid Hydrophilic-Hydrophobic Surfaces for Dropwise Condensation Enhancement
Authors: Croce Giulio , D’Agaro Paola , Suzzi Nicola
Published: October 2019

A langrangian-based phenomenological model, following the evolution of the individual droplets nucleating at random positions, is applied to the simulation and optimization of hybrid, mixed hydrophobic and hydrophilic surfaces. The proposed mathematical model was originally developed to simulate droplets pattern evolution in the framework of in-flight icing problems and takes into account the surface tension effects (via the advancing and receding contact angle values), the external force balance on the single droplets, as well as the both the condensing and coalescence process. Here, the model is extended to the case of an arbitrary curved substrate surface and a parametric analysis of different cases is carried out, looking for the parameters that help to identify the optimal design for a given set of wettability properties, nucleation site density and wet surface condensation rates. A discussion on the sensitivity of the solutions with respect to the expected high uncertainties on the estimate of some of these parameters in actual practical problems is also presented, in order to assess the effectiveness of the simulation as a design tool. The analysis is carried out for condensation enhancement on both plane surfaces and mini or micro tubes. Comparison with experimental, open literature data ensure the reliability of the approach for both geometries.
Enhanced Liquid Water Removal From PEM Fuel Cell Flow Channels by Superimposing Acoustic Pressure Wave on Air Flow
Authors: Mortazavi Mehdi , Santamaria Anthony D. , Benner Jingru , Chauhan Vedang
Published: October 2019

Enhanced water removal from the flow channel of an ex-situ PEM fuel cell test section is obtained by superimposing acoustic pressure wave on air flow prior to entering into the flow channel. Water accumulation within the flow channel was visualized with a CCD camera and liquid-gas two-phase flow pressure drop was measured along the flow channel. Acoustic pressure waves were superimposed in sine waves at different frequencies between 20 and 120 Hz with a 20-Hz interval. Results indicated that water accumulation in the flow channel was lowest when acoustic pressure waves were superimposed at 80 Hz on air flow. For experiments with no acoustic vibration, the average water slug cumulative area for three runs was obtained at 288.6 mm2 while this average was as low as 43.9 mm2 for experiments conducted at 80 Hz. For other frequencies tested (20, 40, 60, 100, and 120 Hz), water accumulation within the flow channel was less than that for experiments with no vibration but the accumulation of water was still greater than experiments conducted at 80 Hz. The two-phase flow pressure drops were also lowest for experiments conducted at 80 Hz while the highest pressure drops were obtained in experiments with no acoustic vibration. Droplets were also visualized from a side-view angle in a goniometer in order to obtain contact angles. Images showed droplet oscillation under the influence of acoustic vibration. For the three superficial air velocities tested in this study (1.30, 1.82, and 2.30 m/s) the contact angle hysteresis were almost identical with an average value around 40°.
Changes in Knee and Trunk Alignment in People With Hip Pain and Healthy Controls When Using a Decline Board During Single-Leg Squat
Authors: Freke Matthew D. , Crossley Kay , Russell Trevor , Sims Kevin J. , Semciw Adam
Published: October 2019

Context: Hip pain is associated with reduced hip muscle strength, range of movement (ROM), and decreased postural stability. Single-leg squat is a reliable and valid method to measure dynamic balance. Objective: To evaluate the influence of physical characteristics and use of a decline board on squat performance in a hip pain population. Design: Cross-sectional study setting. Clinical Patients: In total, 33 individuals scheduled for arthroscopic hip surgery were matched with 33 healthy controls. Interventions: Hip and ankle ROM, hip strength, and trunk endurance were assessed, along with knee and trunk kinematics during squat on flat and 25° decline surfaces. Main Outcome Measures: Between-group and surface differences in alignment, between-group strength and ROM, and associations between alignment and physical characteristics were assessed and determined using mixed model analysis of variance and Pearson R. Results: The hip pain group had significantly less strength and ROM for all directions except abduction strength and ankle dorsiflexion (P > .02). No differences existed between the 2 groups for trunk (P < .70) or knee displacement (P < .46) during squat on either surface. When the 2 groups were combined (n = 66), decline squat significantly reduced knee medial displacement in both limbs by approximately 1 cm (P < .01). Decline squat reduced trunk lateral movement on 1 side only (P = .03). Reduced knee displacement during decline squat showed fair association with less hip-extension strength (r = −.29), hip-flexion strength (r = −.25), and less dorsiflexion (r = −.24). Strength and range were not associated with trunk displacement. Conclusions: Decline squat reduced medial knee and lateral trunk displacement regardless of hip pain. Reductions may be greater in those with lesser hip muscle strength and dorsiflexion. Use of a decline board during squat for improving knee and trunk alignment should be considered as a goal of exercise intervention.
Practical Guidance for Clinical Microbiology Laboratories: A Comprehensive Update on the Problem of Blood Culture Contamination and a Discussion of Methods for Addressing the Problem
Authors: Doern Gary V. , Carroll Karen C. , Diekema Daniel J. , Garey Kevin W. , Rupp Mark E. , Weinstein Melvin P. , Sexton Daniel J.
Published: October 2019

In this review, we present a comprehensive discussion of matters related to the problem of blood culture contamination. Issues addressed include the scope and magnitude of the problem, the bacteria most often recognized as contaminants, the impact of blood culture contamination on clinical microbiology laboratory function, the economic and clinical ramifications of contamination, and, perhaps most importantly, a systematic discussion of solutions to the problem.
An Uncultivated Virus Infecting a Nanoarchaeal Parasite in the Hot Springs of Yellowstone National Park
Authors: Munson-McGee Jacob H. , Rooney Colleen , Young Mark J.
Published: October 2019

Here, we present evidence of the first virus found to infect Nanoarchaeota, a symbiotic archaean found in acidic hot springs of Yellowstone National Park, USA. Using culture-independent techniques, we provide the genome sequence and identify the archaeal host species of a novel virus, NAV1. NAV1 is the first example of a virus infecting an archaeal species that is itself an obligate symbiont and dependent on a second host organism for growth and cellular replication. On the basis of annotation of the NAV1 genome, we propose that this virus is the founding member of a new viral family, further demonstrating the remarkable genetic diversity of archaeal viruses.
Ophthalmic services during ongoing conflict: the eye health system in Yemen
Authors: McMaster David , Bamashmus Mahfouth Abdallah
Published: October 2019

There is little information on the provision of ophthalmic services and the eye health system in Yemen. Using the WHO framework for analysing health systems, we aim to assess what is known about the current eye health system in Yemen with ongoing conflict. Financial constraints, transportation difficulties and security instability are barriers for many of Yemen’s people in need of healthcare. The most recent cataract surgical rate reported in 2012 is 2473 operations per million population, with an increase in operations performed in charity eye camps and the private sector. We identify many governorates of Yemen have inadequate ophthalmic resources. We describe the need for short-term solutions to reduce the backlog prevalence of blindness while local infrastructure is rebuilt, and the importance of long-term reconstruction and transition to local ownership with a sustainable workforce and health service as peace is restored.
Assembly of the LongSHOT cohort: public record linkage on a grand scale
Authors: Zhang Yifan , Holsinger Erin E , Prince Lea , Rodden Jonathan A , Swanson Sonja A , Miller Matthew M , Wintemute Garen J , Studdert David M
Published: October 2019

Background

Virtually all existing evidence linking access to firearms to elevated risks of mortality and morbidity comes from ecological and case–control studies. To improve understanding of the health risks and benefits of firearm ownership, we launched a cohort study: the Longitudinal Study of Handgun Ownership and Transfer (LongSHOT).

Methods

Using probabilistic matching techniques we linked three sources of individual-level, state-wide data in California: official voter registration records, an archive of lawful handgun transactions and all-cause mortality data. There were nearly 28.8 million unique voter registrants, 5.5 million handgun transfers and 3.1 million deaths during the study period (18 October 2004 to 31 December 2016). The linkage relied on several identifying variables (first, middle and last names; date of birth; sex; residential address) that were available in all three data sets, deploying them in a series of bespoke algorithms.

Results

Assembly of the LongSHOT cohort commenced in January 2016 and was completed in March 2019. Approximately three-quarters of matches identified were exact matches on all link variables. The cohort consists of 28.8 million adult residents of California followed for up to 12.2 years. A total of 1.2 million cohort members purchased at least one handgun during the study period, and 1.6 million died.

Conclusions

Three steps taken early may be particularly useful in enhancing the efficiency of large-scale data linkage: thorough data cleaning; assessment of the suitability of off-the-shelf data linkage packages relative to bespoke coding; and careful consideration of the minimum sample size and matching precision needed to support rigorous investigation of the study questions.
Predictors of cardiovascular health in teenagers (aged 13–14 years): a cross-sectional study linked with routine data
Authors: James Michaela , Christian Danielle , Scott Samantha , Todd Charlotte , Stratton Gareth , Demmler Joanne , McCoubrey Sarah , Halcox Julian P , Audrey Suzanne , Ellins Elizabeth Anne , Brophy Sinead
Published: October 2019

Objective

To examine the predictors of cardiovascular health in teenagers (aged 13–14 years).

Methods

Measures of arterial stiffness (augmentation index (AIx)), blood pressure and cardiovascular fitness were taken from 234 teenage children (n=152 boys) and subsequently linked to routine data (birth and general practice records, education data and hospital admission data). Deprivation at school and at individual level was measured at birth, at 1 year old, at 13 years old and at secondary school using the Welsh Index of Multiple Deprivation. Multivariate regression analysis determined associations between routinely collected data and cardiovascular measures.

Results

Teenagers had higher AIx (2.41 (95% CI 1.10 to 3.72)), ran fewer metres (−130.08 m (95% CI −234.35 to −25.78)) in the Cooper Run Test if they attended a more deprived school. However, higher individual level deprivation was associated with greater fitness (199.38 m (95% CI 83.90 to 314.84)). Higher systolic blood pressure was observed in first born children (10.23 mm Hg (95% CI 1.58 to 18.88)) and in those who were never breastfed (4.77 mm Hg (95% CI 1.10 to 8.42)).

Conclusions

Improving heart health in deprived areas requires multilevel action across childhood namely, active play and programmes that promote physical activity and fitness and, the promotion of breastfeeding. Recognition of the important early indicators and determinants of cardiovascular health supports further development of the evidence base to encourage policy-makers to implement preventative measures in young people.
Marine temperature and depth use by anadromous Arctic char correlates to body size and diel period
Authors: Mulder Ingeborg M. , Morris Corey J. , Dempson J. Brian , Fleming Ian A. , Power Michael
Published: October 2019

Acoustic and archival telemetry were used to study the marine movements of 115 anadromous Arctic char (Salvelinus alpinus) at two sites in southern Labrador, Canada, in relation to daily variation in temperature and depth use, body size, and their effects on marine activity patterns. Although evidence varied between locations, Arctic char generally utilized ambient water temperatures available in the upper water column, possibly in aid of physiological processes such as digestion, whereas deeper waters were suggested to be used for feeding purposes. Size-dependent thermal preferences were evident, with larger individuals utilizing cooler water temperatures (8.5 °C) compared with smaller individuals (9.5 °C), a pattern suggestive of ontogenetic changes in thermal habitat use for the purposes of growth maximization. Diurnal patterns of diving activity were interpreted to reflect the vertical migration of prey items and (or) the visual capabilities of Arctic char. Dive duration was dependent on body size and external body temperature with smaller individuals performing shorter dives in colder water temperatures (<1 min at 5 °C) than larger fish (∼2 min at 5 °C), likely to maintain their core temperature and abilities to both effectively capture prey and avoid predation.
Controllability of Networks of Multiple Coupled Neural Populations: An Analytical Method for Neuromodulation’s Feasibility
Authors: Liu Xian , Sun Cheng-Xia , Gao Jing , Xu Shi-Yun
Published: October 2019

Neuromodulation plays a vital role in the prevention and treatment of neurological and psychiatric disorders. Neuromodulation’s feasibility is a long-standing issue because it provides the necessity for neuromodulation to realize the desired purpose. A controllability analysis of neural dynamics is necessary to ensure neuromodulation’s feasibility. Here, we present such a theoretical method by using the concept of controllability from the control theory that neuromodulation’s feasibility can be studied smoothly. Firstly, networks of multiple coupled neural populations with different topologies are established to mathematically model complicated neural dynamics. Secondly, an analytical method composed of a linearization method, the Kalman controllable rank condition and a controllability index is applied to analyze the controllability of the established network models. Finally, the relationship between network dynamics or topological characteristic parameters and controllability is studied by using the analytical method. The proposed method provides a new idea for the study of neuromodulation’s feasibility, and the results are expected to guide us to better modulate neurodynamics by optimizing network dynamics and network topology.
Quasirationality and prounipotent crossed modules
Authors: Mikhovich A. M.
Published: October 2019

We study quasirational (QR) presentations of (pro-[Formula: see text])groups, which contain aspherical presentations and their subpresentations, and also still mysterious pro-[Formula: see text]-groups with a single defining relation. Using schematization of QR-presentations and embedding of the rationalized module of relations into a diagram related to a certain prounipotent crossed module, we derive cohomological properties of pro-[Formula: see text]-groups with a single defining relation.
On links minimizing the tunnel number
Authors: Girão Darlan , Nogueira João Miguel , Salgueiro António
Published: October 2019

We determine a large class of links, including some satellite and hyperbolic links, for each of which the tunnel number is the minimum possible, the number of its components minus one, and observe that the rank versus genus conjecture is valid for this class of links.
Convergence analysis of distributed multi-penalty regularized pairwise learning
Authors: Hu Ting , Fan Jun , Xiang Dao-Hong
Published: October 2019

In this paper, we establish the error analysis for distributed pairwise learning with multi-penalty regularization, based on a divide-and-conquer strategy. We demonstrate with [Formula: see text]-error bound that the learning performance of this distributed learning scheme is as good as that of a single machine which could process the whole data. With semi-supervised data, we can relax the restriction of the number of local machines and enlarge the range of the target function to guarantee the optimal learning rate. As a concrete example, we show that the work in this paper can apply to the distributed pairwise learning algorithm with manifold regularization.
Optimized Condition for Pairing of Different Friction Factor and Viscosity Equations for the Frictional Pressure Drop of R22 and R290
Authors: Yousif Qais Abid , Mohd-Ghazali Normah , Pamitran Agus Sunjarianto , Mohd-Yunos Yushazaziah
Published: October 2019

Accurate prediction of the friction factor and consequently the pressure drop of two-phase flow in small channels is still an issue. Many correlations exist for the determination of the viscosity and the friction factor that appear in the frictional pressure drop and their combination often determined the degree of disagreements between the experimental data and predicted outcomes. Demands for environmentally friendly refrigerants have further posed a challenge to find compatible alternatives with as good a performance as the current coolants. Despite the many available correlations developed to date, many more are studied in effort to reduce the discrepancies. This paper presents the outcomes of a study comparing the optimized conditions when three different viscosity equations are paired with eight different friction factor correlations to minimize the frictional pressure drop. The approach used multi-objective genetic algorithm (MOGA) to assist in selecting the best pairing. Comparison is then completed with available experimental data. The study showed that the Blasius friction factor paired with the Dukler viscosity produced the least percentage difference for R22, while when paired with the McAdams viscosity produced a lower difference for R290, an environmentally friendly refrigerant being considered to replace R22.
An Empirical Examination of Mutual Fund Boards
Authors: Meschke Felix
Published: October 2019

This paper examines how board independence and director incentives in the mutual fund industry affect fund expenses, performance, and compliance. It is based on a hand-collected panel dataset of mutual fund governance characteristics from 1995 through 2004, which covers about 60% of assets listed in the CRSP mutual fund database. The results show that funds overseen by an independent chair charge fees that are 12 basis points lower and that the fraction of independent directors is associated with higher fees during the earlier part of the sample and with lower fees during the latter part. Both measures of board independence are associated with lower fund performance, although funds with higher director ownership and lower unexplained compensation charge lower fees and deliver higher returns. Fund board characteristics do not seem to affect the likelihood of litigation by regulators and shareholders. These results suggest that fund investors do not necessarily benefit from greater board independence if boards negotiate low fees without closely evaluating fund performance. In contrast, higher director ownership and relatively low compensation seem to align incentives between fund boards and investors.
The evolution of the Dowsing Graben System: implications for petroleum prospectivity in the UK Southern North Sea
Authors: Grant Ross J. , Underhill John R. , Hernández-Casado Jaume , Jamieson Rachel J. , Williams Ryan M.
Published: October 2019

Upper Permian (Zechstein Supergroup) evaporites have a major control on structural styles and prospectivity in the UK Southern North Sea (SNS). They form the regional super-seal for the main Rotliegend Group (Leman Sandstone Formation) reservoir play fairway immediately beneath. The evaporites have highly variable thicknesses due to the syndepositional basin architecture, differential loading and post-depositional deformation through diapirism and salt withdrawal. The halokinetic activity leads to touchdown (welding) of the supra-salt section onto the sub-salt strata and the development of narrow (up to 15 km-wide) graben systems. The interpretation and depth conversion of well-calibrated, high-quality, 3D post-stack time-migrated (PSTM) seismic data along the southwestern margin of the basin show that a NW–SE-striking elongate extensional Dowsing Graben System transects the area. The graben is defined by a series of large, overlapping, en echelon listric growth faults, with oblique secondary planar faults, which sole-out on two main (deep and shallow) décollement levels in the Zechstein Supergroup and the Middle Triassic Röt Halite Member. Whilst its initial formation was related to Mesozoic extension, the graben system also displays a contractional overprint resulting from regional compression and structural inversion during the Cenozoic. Detailed mapping of the Zechstein Supergroup has revealed that the evolution of the extensional system was influenced by the ESE–WNW-striking anhydrite–carbonate Zechstein shelf-margin. The occurrence of variable-thickness, low-velocity sediments within the graben impacts seismic imaging and depth conversion, leading to prospective structures being overlooked; something that has implications for prospectivity in the SNS and other evaporite basins where similar graben occur.
Magnetic Nanoparticles@Metal-Organic Framework Composites as Sustainable Environment Adsorbents
Authors: Zhao Gege , Qin Nianqiao , Pan An , Wu Xiaoyan , Peng Chuanyi , Ke Fei , Iqbal Mudassar , Ramachandraiah Karna , Zhu Jing
Published: October 2019

Metal-organic frameworks (MOFs) are an intriguing class of porous inorganic-organic hybrid networks synthesized from metal ions with multidentate organic ligands. MOFs have uniform and tunable cavities and tailorable chemistry, making them promising materials for hazardous component removal from the environment. Controllable integration of magnetic nanoparticles (NPs) and MOFs is leading to the creation of many novel multifunctional MOF-based composites, which exhibit advanced performance that is superior to both of the individual units. This review summarizes the recent significant advances in the development of MOF-based magnetic heterostructure materials for the removal of hazardous contaminants from the environment. The successful methods reported till date for the magnetic MOF synthesis are also provided. In the final section, we provide our views on the future development of the magnetic MOF heterostructure materials for the pollution management.
Vibration Isolation of Existing Buildings in Microvibration Traffic Environment
Authors: Xia Qian , Qu Wen-jun , Li Yi-qing , Zhao Jin
Published: October 2019

In order to explore the impact of traffic environmental microvibration on buildings, this paper studies indoor vibration isolation, a method applicable to existing buildings. The vibration isolation scheme is designed based on the residential buildings adjacent to metro lines in Shanghai. By using the dynamic theory, the effective range of vibration isolation stiffness is analyzed. The effectiveness of the indoor vibration isolation method is verified through theoretical calculations and comparison of field measurements before and after isolation. A detailed numerical model is established to analyze the indoor isolation and the effect after parameter optimization from the slab thickness, filling material, and isolator stiffness. The results show that the isolation effect is proportional to the thickness of the total slab thickness of the isolation system and inversely proportional to the stiffness of the isolator. And when concrete is used as the filling material, the isolation effect is best. The isolation effect of the midspan position is better than that of the wall‐floor junction. The vibration isolation effect is more obvious after the parameters are optimized. With its convenient construction technology, short cycle, and low cost, this method is worth promoting.
Highly Aggressive CD4-Positive Mast Cell Leukaemia (Leukaemic Variant) Associated with Isolated Trisomy 19 and Hemophagocytosis by Neoplastic Mast Cells: A Case Report with Challenging Experience and Review
Authors: Soliman Dina Sameh , Al-Sabbagh Ahmad , Ibrahim Feryal , Gameil Amna , Yassin Mohamed , El-Omri Halima
Published: October 2019

Background. Mast cell leukaemia is a unique disease among hematopoietic neoplasms, being one of the rarest leukaemia subtypes. In addition, its prompt diagnosis is usually challenging. This is due to its heterogeneity in clinical presentations and cytomorphological and immunophenotypical features together with potential associations with other hematologic neoplasms which can complicate the condition and delay accurate diagnosis. To the best of our knowledge, this is the first case report of CD4-positive mast cell leukaemia. Case Presentation. A 39-year-old male presented with acute onset of fever, abdominal pain, and generalized body aches of two-week duration. Peripheral blood smear showed circulating blasts (13%) with coarsely basophilic granulation. Bone marrow (BM) aspirate showed extensive infiltration with immature mast cells of blast-like morphology with trilineage dysplasia and evident hemophagocytic activity exhibited by histiocytes and neoplastic mast cells. BM biopsy was diffusely infiltrated with many atypical mast cells positive for CD45, CD117, mast cell tryptase, CD25, and CD4 with partial positivity for CD7 and CD30. Cytogenetics showed an abnormal karyotype: 47, XY, +1947, XY, +19[13]/46, XY[9]. Molecular analysis revealed a KIT D816V mutation consistent with a diagnosis of systemic mastocytosis, mast cell leukaemia. Conclusion. The expression of T-cell associated markers by abnormal mast cells is well documented; however, CD4 and CD7 expression have not previously been described in association with mast cell leukaemia. Coexpression of CD2, CD4, CD7, and CD30 by the mast cells particularly in skin lesions may provoke misinterpretation as a cutaneous T-cell neoplasm. To the best of our knowledge, this is the first report of CD4-positive mast cell leukaemia. Moreover, hemophagocytic mast cell leukaemia is a very rare morphologic variant, and possible correlation between this finding and expression of CD4 by neoplastic mast cells is a topic for further investigation.
Mineralogy Characteristic Study and Exploration on the Valuable Metals Enrichment of Coal Fly Ash
Authors: Chen Tao , Yan Bo , Li Li-li , Yan Zi-Ang , Wang Jun , Xiao Xian-ming
Published: October 2019

The separation and enrichment can be targeted to enrich in fly ash and reduce the cost of leaching and recovering of fly ash. Regarding their different properties, the single-component separation was used to obtain uncompleted burned carbon, glass microbeads, minerals, and other characteristic components from the ash. Also, the mineral composition of each component was analyzed by electron microscopy. The metal minerals were mainly concentrated in the mineral components. Besides, the electron probe microanalysis shows that the Pt content in the minerals of fly ash was significantly correlated with the metal contents of Ni and Cu. After the obtainment of the characteristics of fly ash metal enrichment, the heavy minerals with Cu, Ni, Pt, Pd, and other target metal elements were enriched by gravity separation and flotation. The enrichment coefficients of Cu, Ni, Pt, and Pd were 1.45, 1.33, 1.90, and 1.60, respectively, and the recovery rates were 77%, 81%, 97%, and 88%, respectively. Since the yield of heavy minerals obtained by separation was 62.24%, it indicated the physical separation method could significantly reduce the cost of leaching and recovering of fly ash metal resources.
Assessment of Toxicity and Therapeutic Effects of Goose Bone in a Rat Model
Authors: Ali Md. Yousuf , Kabir Alamgir , Khandker Shahad Saif , Hossan Tareq , Shakil Md. Salman , Islam Md. Aminul , Hasan Md. Ashraful , Hossen Md. Sakib , Gan Siew Hua , Khalil Md. Ibrahim
Published: October 2019

Goose bone is traditionally used in the treatment of many ailments including in bone fracture. The aim of the present study was to evaluate the subacute toxicity of goose bone in a rat model by investigating some hematological and biochemical parameters in rats. Subsequently, a histopathological study was performed to confirm the presence of pathological lesions in the rat’s vital organs including the liver, kidney, heart, brain, pancreas, lung, spleen, and stomach. Adult Wistar rats were divided into four groups (n = 8) and were orally administrated with three doses (30, 60, and 120 mg/kg) of goose bone once daily for 21 days as compared to control animals (received only drinking water). Goose bone did not cause any significant changes on body weight, relative organ weight, and percentage water content at any of the administered doses. There were also no significant alterations in hematological parameters seen. All three doses administered significantly reduced the triglyceride levels as well as the atherogenic index of plasma (AIP). Animals treated with 120 mg/kg doses had significantly reduced alkaline phosphatase (ALP) activity as compared to the control group. There was no significant alteration on other serum biochemical parameters seen. Additionally, histopathological findings confirmed that there was no inflammatory, necrotic, or other toxicological feature seen for all three doses. It is concluded that goose bone is nontoxic and is safe for consumption besides having the potential to be investigated for the treatment of high triglycerides or liver-related disorder.
Iterative Analysis of the Unique Positive Solution for a Class of Singular Nonlinear Boundary Value Problems Involving Two Types of Fractional Derivatives with p‐Laplacian Operator
Authors: Wang Fang , Liu Lishan , Wu Yonghong , Zou Yumei
Published: October 2019

This article is concerned with a class of singular nonlinear fractional boundary value problems with p‐Laplacian operator, which contains Riemann–Liouville fractional derivative and Caputo fractional derivative. The boundary conditions are made up of two kinds of Riemann–Stieltjes integral boundary conditions and nonlocal infinite‐point boundary conditions, and different fractional orders are involved in the boundary conditions and the nonlinear term, respectively. Based on the method of reducing the order of fractional derivative, some properties of the corresponding Green’s function, and the fixed point theorem of mixed monotone operator, an interesting result on the iterative sequence of the uniqueness of positive solutions is obtained under the assumption that the nonlinear term may be singular in regard to both the time variable and space variables. And we obtain the dependence of solution upon parameter. Furthermore, two numerical examples are presented to illustrate the application of our main results.
Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence
Authors: Wei Jiahui , Zhao Binxin , Zhang Chengling , Shen Bingbing , Zhang Ying , Li Changxi , Chen Yi
Published: October 2019

Foshou San is a typical gynaecological formula with wild usage in traditional Chinese medicine. Jiawei Foshou San (JFS) is a novel ingredient prescription from Foshou San with antiendometriosis effect in unclear mechanisms. To uncover the potential application and proapoptotic mechanisms of JFS, JFS ingredient-drug target-disease networks, GO enrichment, and pathway analysis were established for potential application prediction. Molecular docking and validation in vivo were investigated by the proapoptotic mechanisms of JFS. In this study, 99 common targets were related to 108 diseases. 484 biological processes, 44 cell components, 59 molecular functions, and 37 pathways were significantly identified in GO enrichment and pathway analysis. In molecular docking, ligustrazine showed binding activity with Bcl-2, Bax, caspase-9, caspase-3, and PARP. In vivo, JFS elevated the shrink rate of ectopic endometrium, by suppressing E2 and PROG. An in-depth study showed that apoptosis was activated through diminishing Bcl-2, rising Bax and Bad, and expressing more caspase-3 and caspase-9 using JFS. JFS promoted the protein level of cleaved-PARP. In brief, JFS might be applied for various diseases through multiple targets and pathways, especially endometriosis by Bcl-2 pathway. These findings reveal the potential application for further evaluation and uncover the proapoptotic mechanism of JFS.
The Effect of Different Acupuncture Therapies on Neurological Recovery in Spinal Cord Injury: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Authors: Xiong Feng , Fu Chenying , Zhang Qing , Peng Lihong , Liang Zejun , Chen Li , He Chengqi , Wei Quan
Published: October 2019

Many acupuncture therapies were used to treat spinal cord injury (SCI) and its complications. The difference in efficacy among these therapies has not been assessed. To compare the efficacy of different acupuncture therapies for SCI, we searched databases (PubMed, Embase, Cochrane Library, CNKI, and WanFang) for relevant RCTs in both English and Chinese before June 2019 that reported the association between acupuncture therapies and SCI. The RCTs were categorized according to the location of the acupoints used in them. The neural function was assessed by American Spinal Injury Association (ASIA) motor score, and daily living ability was accessed by Modified Barthel Index (MBI) after SCI. In total, 22 trials involving 1644 participants were included. The pairwise meta-analysis and random effects model network meta-analysis were conducted. The results indicated that exercise combined with electro-acupuncture (EA) is superior to exercise without acupuncture in improving the ASIA motor score. EA was associated with a significantly higher improvement in the MBI score than exercise alone, except for EA of head + limbs and limbs. Additionally, EA on the head + back and back + front (chest and abdomen) rank the top in both increasing the ASIA motor score and the MBI score. Acupuncture can significantly increase motor function and daily living ability of individuals who suffer from SCI, especially acupuncture of the back + front or the head + back. The evidence supports acupuncture of the back + front or the head + back as an effective treatment for SCI.