bluuebunny/crossref_metadata_2025 huggingface dataset:
Tablet Formulation Studies on Recrystallized Active Pharmaceutical Ingredients of Valsartan and Olmesartan Medoxomil
Authors: Rao TP. , Nalluri Buchi N.
Published: December 2021

Both the Valsartan (VAL) and Olmesartan medoxomil (OLM) are widely prescribed anti-hypertensive agents with angiotensin II type I receptor antagonistic activity. Both VAL and OLM are type of BCS class II drugs and having a low and variable oral bioavailability.  Recrystallization of VAL and OLM from different organic solvents improved its aqueous solubility and thereby in vitro dissolution properties. In the present investigation, tablets containing Valsartan (VAL), Olmesartan medoxomil (OLM and)  recrystallized products were prepared by  direct compression method and evaluated for drug content, uniformity of weight, hardness, friability, disintegration time and dissolution properties. All the tablets fulfilled the compendial requirements with regarding to weight variation, friability and disintegration time etc for immediate release tablets.  The DP15 (drug percent dissolved at 15 min) values for V-1 (tablets of VAL), V-4 (tablets of methanol recrystallized product with crospovidone as disintegrant) and DIOVAN™ 40mg tablet formulations are 45.97,  98.95 and 82.65 respectively and V-4 formulation showed higher dissolution rate when compared to other formulations. The DP15 values of O-1(tablets of OLM), O-4 (tablets of acetonitrile recrystallized product with crospovidone as disintegrant and OLMY™ (20mg) tablet formulations are 29.25, 99.93 and 84.82 respectively. O-4 tablet formulations showed higher dissolution rate when compared to other tablet formulations.

Keywords: Valsartan, Olmesartan medoxomil, Recrystallization, Aqueous solubility
In-Situ Ocular Gel Pharmaceutical Delivery System: A Recent Review
Authors: Kapila Sohan , Dev Dhruv , Prasad D.N.
Published: December 2021

Ocular Drug Delivery has been a key challenge and attractive field for the pharmaceutical scientist due to peerless anatomy and physiology of eye. Glaucoma, dry eye syndrome, keratitis, endophthalmitis, trachoma, and conjunctivitis are just a few of the conditions that can affect the eye. In order to accomplish efficient ocular treatment within the eye, At the point of action, an appropriate supply of active substances must be given and sustained. Due to fast precorneal medication loss, traditional treatment has a low bioavailability. The bioavailability of a medicine is also influenced by static and dynamic barriers. To address the limitations of traditional treatment, significant efforts are being made to develop innovative medication systems for ocular delivery. When a drop is injected into the eye, it goes through a sol-gel transition and forms a cul-de-sac. The in-situ gel system, which comprises thermally triggered, pH triggered, and ion cross linking systems, is the subject of this review. It includes a step-by-step procedure for preparing the pH-triggered system as well as assessment parameters.

Keywords: Conventional dosage form, Anatomy and physiology in eye, In-situ gel.
Improving the Accuracy of Aerial Photography Using Ground Control Points
Authors: Kurbanov R. K. , Zakharova N. I. , Gorshkov D. M.
Published: December 2021

The authors showed that it is possible to quickly collect up-to-date information on the agricultural land condition using an unmanned aerial vehicle. It was noted that the use of ground control points increases the accuracy of project measurements, helps to compare the project post-processing results with the real measurements. (Research purpose) To compare the results of standard and high-precision post-processing of aerial survey data using ground control points. (Materials and methods) Aerial photography was carried out on a 1.1- hectare breeding field. The authors used DJI Matrice 200 v2 unmanned aerial vehicle with a GNSS L1/L2 receiver and a modified DJI X4S camera, five control points sized 50 × 50 centimeters and an EMLID Reach RS2 multi-frequency GNSS receiver. The results of scientific research into the use of ground control points during aerial photography were studied. (Results and discussion) It was found out that the error of georeferencing images obtained by an unmanned aerial vehicle without control points is significantly higher during the standard data processing compared to the high-precision one. The project error when using five control points is 3.9 times higher during the standard data processing. (Conclusions) It was shown that using ground control points it is possible to improve the project measurement accuracy, as well as compare the project post-processing results with the measurements on the ground. It was detected that the high-precision monitoring enables the use of fewer ground control points. It was found out that in order to obtain data with the accuracy of 2-4 centimeters in plan and height, at least 3 ground control points need to be used during the high-precision post-processing.
Tissue Wrapping Augmentation for Anterior Cruciate Ligament Reconstruction
Authors: Jacob George , Shimomura Kazunori , K Yogesh , Nakamura Norimasa
Published: December 2021

Anterior cruciate ligament reconstruction (ACLR) has become a popular surgery in orthopedic practice today, and the technique has evolved significantly over time. Surgical procedure, graft choice, and fixation systems have varied over the years. Nonetheless, several challenges like insufficient graft ligamentization, tunnel enlargement, and insufficient reestablishment of proprioception remain in ACLR. A vision of better graft healing and integration for improved outcomes after ACLR introduced the idea of the biological ACLR. Various techniques with growth factors, cellular therapies, or tissue augment have been researched with ACLR surgery for better integration and ligamentization. This review highlights the tissue wrappingmodalities currently being explored in biological ACLR.
Territorial Public Self-Government as an Element of Political Infrastructure for Secure Development of Municipal Sections in the Conditions of Digitalization
Authors: Shchegolev E. N.
Published: December 2021

The research is devoted to the topic of forming a political infrastructure for the safe development of municipalities, creating technologies for attracting political infrastructure participants to the development and assessment of alternatives for the optimal development of territories.

We set ourselves the goal of showing territorial public self-government as a tool for increasing the openness of political decision-making and public confidence in the authorities, and identifying the transformational potential of digital technologies in the context of territorial public self-government.

The methodological basis of the research was provided by such theories as: the information cybernetic model of the political system of K. Deutsch, the theory of the political system of D. Easton, the theory of deliberative democracy by J. Besset, the theory of direct democracy I. Blo, model of monitor (digital) democracy by J. Keane.

The main results of this study are the following:

1) the author’s definition of the concept of “digitalization” was introduced — this is a process of radical transformation of the interaction of people in all spheres of social life, the implementation of which became possible on the basis of replacing analog (physical) data collection and processing systems with new technological systems that generate, transmit and process a digital signal about your condition. This transformation presupposes the formation of a different outlook of citizens, the use of other methods of management;

2) the author’s definition of the concept of “political infrastructure” is introduced — these are the types of connections between the elements of the political system. Different types of ties form various modifications of political institutions, they determine the contours of political communications carried out in the political space, including using various political technologies to influence the behavior of political forces.

3) in the context of digitalization, interactive interaction of participants in the political process, the very configuration of the political infrastructure for the development of territories is changing, the political toolkit of dialogue between the authorities and society is changing, implying an increasingly widespread use of technologies to involve participants in political processes in the development and assessment of alternatives for optimal territorial development.
Propiedades físicas de productos cocristalizados de jugo de maracuyá y pulpa de guayaba y su cinética de cocristalización
Authors: Torres-Gallo Ramiro , Arteaga-Cavadia Teófilo , Montes-Montes Everaldo
Published: December 2021

La cocristalización con sacarosa se ha utilizado para obtener productos con mejores propiedades físicas, como solubilidad, humectabilidad, hidratación y estabilidad, así como para preservar los componentes activos presentes en la mayoría de las futas. El objetivo de este trabajo fue determinar el efecto del pH y concentración de pulpa de guayaba (Psidium guajava L) y jugo de maracuyá (Passiflora edulis, en adelante concentración de fruta), sobre la humedad, la densidad aparente, la solubilidad, el ángulo de reposo, la higroscopicidad y la cinética de cocristalización de productos cocristalizados de jugo de maracuyá y pulpa de guayaba. Se prepararon los cocristalizados con jarabe de sacarosa a 70 °Brix, pulpa de guayaba concentrada a 18 °Brix y el jugo de maracuyá a 40 °Brix. Para concentrar las mezclas y prepararlas para la cocristalización se utilizó un evaporador rotativo Heidolph D-91126 HB y un controlador de vacío Heidolph DC1/1HO. La cinética de cocristalización se evaluó utilizando un reómetro TA Instrument AR 1500ex, determinando la viscosidad compleja en el tiempo, a través de una rampa de temperatura de 80 °C a 15 °C a 1 Hz, descendiendo 6,5 °C/min, ajustando los datos experimentales a un modelo empírico. El aumentar la concentración de fruta añadida en el proceso, aumentan el tiempo de cristalización y la humedad final del producto, y disminuye su solubilidad. La velocidad de cocristalización se ve favorecida por la menor concentración de fruta, presentándose una mayor velocidad de cristalización para los cocristalizados de pulpa de guayaba que en los de jugo de maracuyá.
FORMULASI BISKUIT KEPILOR (KECAMBAH KEDELAI, PISANG KEPOK MERAH, DAUN KELOR) SEBAGAI KUDAPAN SEHAT BAGI PENDERITA DIABETES MELITUS
Authors: Palupi Fitria Dhenok , Nafilah Nafilah
Published: December 2021

Latar Belakang. Diabetes melitus (DM) merupakan salah satu masalah kesehatan yang ditandai dengan peningkatan kadar glukosa darah. Konsumsi makanan rendah indeks glikemik yang mengandung pati resisten, asam amino esensial, vitamin, mineral, dan antioksidan membantu terapi DM. Makanan tersebut dapat dikembangkan dari bahan pangan lokal, yaitu pisang kepok (Musa paradisiaca), kedelai (Glycine max), dan daun kelor (Moringa oleifera). Tujuan. Penelitian ini bertujuan untuk mengembangkan formulasi biskuit berbasis dasar tepung kecambah kacang kedelai, pisang kepok, dan daun kelor (kepilor) sebagai kudapan sehat bagi penderita DM sehingga membantu mencegah terjadinya komplikasi. Metode. Penelitian dilakukan dengan metode penelitian eksperimental dengan rancangan acak lengkap (RAL) dengan 3 proporsi formulasi (P1, P2, dan P3) dan satu kontrol (P0). Penepungan, pembuatan biskuit, dan uji organoleptik dilaksanakan di laboratorium Ilmu Teknologi Pangan, Poltekkes TNI AU Adisutjipto, sedangkan analisis kadar gizi dilaksanakan di Laboratorium Pusat Studi Pangan dan Gizi (PSPG), Universitas Gadjah Mada. Data hasil uji organoleptik dan kadar gizi dianalisis menggunakan software SPSS dengan uji Anova dengan tingkat kemaknaan p<0,05 dan bila sangat berbeda nyata dilakukan uji lanjut dengan uji DMRT. Hasil. Subtitusi tepung kepilor menurunkan daya terima panelis secara signifikan pada atribut warna, aroma, rasa, dan tekstur biskuit kepilor yang dihasilkan. Penambahan tepung kepilor meningkatkan kadar air, abu, protein, lemak, pati, dan serat serta menurunkan kadar lemak dan karbohidrat biskuit kepilor dibandingkan dengan biskuit kontrol. Kadar protein pada biskuit kepilor telah memenuhi SNI biskuit, tetapi kadar air biskuit kepilor belum memenuhi. Kadar karbohidrat, protein, dan lemak pada biskuit kepilor formulasi P1–P3 telah memenuhi syarat diet penderita diabetes melitus. Kesimpulan. Kandungan zat gizi biskuit kepilor terpilih adalah formula P1 kadar air 5,46 persen, kadar abu 2,11 persen, kadar protein 14,91 persen, kadar lemak 18,63 persen, kadar karbohidrat 58,95 persen, kadar serat 0,69 persen, dan kadar pati 41,82 persen.
Penerapan Decision tree dalam pengambilan keputusan untuk pemain Texas Holdem Poker
Authors: Indriyanti Prastika , Fazalika Hismawan Muhamad , Mujiono Mujiono
Published: December 2021

Abstract Texas holdem poker is a popular poker game. This game is played by millions of people every day, both to find additional income or just for fun. But in fact not everyone who plays poker with these goals gets according to what they have planned. Some people actually experience losses after playing. They unconsciously develop the logic of gambler's fallacy that causes them to play poker without using strategy.  This research made a system that can prove the defect of gambler's fallacy and made a tool for playing poker. The processed dataset is a dataset containing information of cards used in poker and their probability of occurrence. The method used in this research are iterative deepening search tree and decision tree. The main results of this research is a tool that can provide insight as a basis for decision making. However, this tool has not been able to prove its capabilities in helping to increase the winning percentage, so that further study is needed. In addition, this study also shows that playing with gambler's fallacy logic only gives 48.13% wins of 6,000 trials. These results proved that using gambler's fallacy logic in playing poker is a mistake.Keywords – Tree, Poker, Probability, Gambler’s Fallacy Abstrak Texas holdem poker merupakan permainan poker yang populer. Permainan ini dimainkan oleh jutaan orang setiap harinya, baik untuk mencari penghasilan tambahan ataupun hanya untuk bersenang-senang. Namun pada kenyataanya tidak semua orang yang bermain poker dengan tujuan tersebut mendapatkan sesuai dengan apa yang mereka rencanakan. Sebagian orang justru mengalami kerugian pasca bermain. Mereka tanpa sadar mengembangkan logika berpikir gambler’s fallacy yang mengakibatkan bermain tanpa strategi. Makalah ini menyajikan hasil studi penerapan pohon keputusan dan pohon pencarian untuk membuktikan kecacatan gambler’s fallacy dan membantu dalam bermain poker. Dataset yang diolah adalah dataset yang berisi informasi kartu-kartu yang dipakai dalam permainan serta probabilitas kemunculannya. Metode yang digunakan pada penelitian ini adalah metode pencarian pada struktur tree dan metode pohon keputusan. Hasil utama dari penelitian ini adalah alat bantu yang mampu memberikan insight sebagai dasar pengambilan keputusan.  Namun, alat bantu ini belum bisa dibuktikan kapabilitasnya dalam membantu menaikkan persentase kemenangan sehingga diperlukan studi lanjutan. Selain itu, penelitian ini juga menunjukkan bahwa bermain dengan logika gambler’s fallacy hanya memberikan 48.13% kemenangan dari 6000 percobaan. Hasil tersebut membuktikan bahwa menggunakan logika gambler’s fallacy dalam bermain poker merupakan suatu kesalahan.Kata kunci – Tree, Poker, Probabilitas, Gambler’s Fallacy
Perbandingan Hasil Forensics Jaringan Terhadap Serangan E-mail Spamming dan Spoofing
Authors: Tella Fitriyani , Riadi Imam , . Sunardi
Published: December 2021

Abstract In the era of technology, email has become one of the important things in the means of communication. Email is a medium for communication and also a place to store crime. One common crime is email spamming and spoofing. Spam is junk mail or unwanted messages, this spam email will be sent to someone's inbox and is useless to the recipient. Spam is sent on the network to increase network traffic. Email spoofing is a way to hide the origin of messages used by spammers. Email spoofing can change the email sender's information ie in the "From" field. Email spoofing comes from the sender which will make the email look like the real sender. The technique used to determine the comparison of email spoofing and spamming attacks using a method is the Network Forensics Development Life Cycle (NFDLC). Network forensics is performed to find out the IP address of the spamming and spoofing e-mail attacks. This research will also produce an email forgery pattern in the header, place and date of the perpetrators of the crime attacks.Keyword: articles, english, Abstracts Abstrak Pada Era teknologi sekarang email telah menjadi salah satu hal yang penting dalam sarana komunikasi. Email merupakan salah satu media untuk berkomunikasi dan juga menjadi tempat untuk menyimpan kejahatan. Salah satu kejahatan yang sering terjadi adalah email spamming dan spoofing.  Spam adalah junk mail atau pesan yang tidak diinginkan, spam email ini akan dikirimkan kepada inbox mail seseorang dan tidak berguna untuk penerima. Spam dikirim pada jaringan untuk meningkatkan lalu lintas jaringan. Email spoofing adalah cara untuk menyembunyikan asal usul pesan yang digunakan oleh spammer. Email spoofing dapat mengubah informasi pengirim email yaitu pada bidang “From”. Email spoofing berasal dari pengirim yang akan menjadikan email tampak seperti pengirim sebenarnya. Teknik yang dilakukan untuk mengetahui perbandingan dari serangan email spoofing dan spamming yaitu menggunakan metode adalah Network Forensics Development Life Cycle (NFDLC). Dilakukan forensik jaringan guna mengetahui ip address dari serangan email spamming dan spoofing tersebut. Penelitian ini juga akan menghasilkan pola pemalsuan email pada header,  tempat dan tanggal dari pelaku melakukan serangan kejahatan. Keyword: Forensik Jaringan, E-mail Spamming, E-mail Spoofing
USE OF THREE-DIMENSIONAL ENDOSCOPY IN ENDONASAL AND ANTERIOR SKULL BASE SURGERY
Authors: Kholief Amr , Youseef Ahmed , Ibrahim Ahmed , Elwany Samy , Ahmed Shahz
Published: December 2021

Objectives: The three dimensional (3D) endoscope is considered as a new
surgical tool which used in different approaches in intranasal and
anterior skull base surgical procedures. There are many advantages of
the 3D endoscopy over the two dimensional (2D) one that have been
demonstrated along clinical applications, surgical training and
different experimental studies. Our study aimed to show the difference
between using the 3D & 2D endoscopes during endonasal and anterior
skull base surgery and its importance specially when used by novice
users. Design: Our study is divided into two phases (clinical &
cadaveric phases).In the clinical study we have done 52 endonasal &
anterior skull base surgical procedures (26 study cases and 26 control
cases).We recorded accuracy, duration and intraoperative complication
for each case. The cadaveric study was performed on three cadavers,
difference in accuracy and dissection time were recorded using 3D & 2D
endoscopy for each side chosen by randomization. Results: In the
clinical study, the cases done by 3D endoscope were significantly faster
and more accurate with less intraoperative complications compared to
cases done using 2D endoscope. In cadaveric dissection while using 3D
endoscope there was better depth of perception regarding the anatomical
landmarks compared to 2D endoscope. Conclusion: 3D endoscopy is an
advanced instrument that allows better training for the coming
generation of ENT surgeons. Both clinical and cadaveric studies offer a
promising outcomes in both endonasal and anterior skull base surgery.
Universal Health (UHC) and Primary Health Care (PHC) – a complex dynamic endeavour
Authors: Martin Carmel , Sturmberg Joachim
Published: December 2021

The Universal Health (UHC) movement in its latest iteration, has adopted
key objectives of Primary Health Care (PHC). This is a notable shift in
the right direction but achieving what appears to be simple targets is a
highly complex endeavour across both wealthy and less wealthy countries
and jurisdictions. Improving health for all targets requires
political-economic, bureaucratic and alignment with bottom-up
grass-roots agencies. Despite present successes, there is a need to
adapt to constant challenges including pandemics, adverse climate
phenomena and political-economic shifts.
Endometrial cancer after the Manchester procedure: a nationwide cohort study
Authors: Husby Karen , Gradel Kim , Klarskov Niels
Published: December 2021

Objectives To investigate whether the Manchester procedure affects the
risk and prognosis of endometrial cancer. Design Nationwide historical
cohort. Setting The nationwide Danish registers including all residents
with lifelong follow-up. Population All Danish women born 1947–2000,
living in Denmark at one point during 1977–2018 undergoing the
Manchester procedure (N = 23,935) or anterior colporrhaphy (reference
group N = 51,008) during 1977–2018. Methods We conducted a nationwide
cohort with full follow-up. Chi-Square test for trend to compare the
diagnostic stage for the two groups of women. Cox Regression to analyse
the risk of endometrial cancer and mortality. The models were adjusted
for age, calendar year, income level, and parity. Main outcome measures
Number of women diagnosed with endometrial cancer, the stage of
endometrial cancer at the time of diagnosis and the cancer specific and
overall mortality. Results During the follow up (median 13 years), 271
(1.13%) women were diagnosed with endometrial cancer after the
Manchester procedure and 520 (1.05%) after anterior colporrhaphy. The
adjusted hazard ratio (HR) for endometrial cancer was 1.00 (95%
confidence interval (CI) 0.86 to 1.16). No difference in stage of cancer
was found (p=0.18), nor when stratifying for calendar year. The HR for
cancer specific mortality and overall mortality after the Manchester
procedure was 0.86 (95% CI 0.65 to 1.15) and 0.93 (95% CI 0.77 to
1.12) respectively. Conclusions The Manchester procedure does not affect
the risk or prognosis of endometrial cancer. Keywords Epidemiology,
endometrial cancer, Manchester procedure, uterine prolapse, pelvic organ
prolapse, vaginal hysterectomy
Turističko i prostorno planiranje u Hrvatskoj i Jugoslaviji 1960-ih
Authors: Kranjčević Jasenka
Published: December 2021

U radu se na temelju tadašnje i recentne (domaće i strane) literature te
prostornih planova istražuje međuodnos turističkoga i prostornoga planiranja u Hrvatskoj i Jugoslaviji 1960-ih. Analitičko-interpretativnom metodom proučava se međuodnos tadašnjega društveno-političkog sustava, politika prema turizmu i prostoru, društvenoga planiranja, tijela uprave, institucija specijaliziranih za planiranje, turističkoga prometa, izrađenih prostornih planova, intenziteta izgradnje smještajnih kapaciteta i dr. Zaključuje se da su turističko i prostorno planiranje međusobno bili povezani društvenim planovima razvoja, a rezultati djelovanja u prostoru ovisili su o brojnim, često i nepredvidivim društveno-političkim čimbenicima. U praksi je provedba planova dodatno usložnjena jer su oni često djelovali
apstraktno i kontradiktorno u političkom sustavu koji je imao ograničenu sposobnost za provedbu kvalitetnih, ali ponekad i utopijskih ideja.
Micropolar fluid between two coaxial cylinders (numerical approach)
Authors: Salemovic Dusko , Dedic Aleksandar , Jovanovic Bosko
Published: December 2021

The paper describes the flow of a suspension which is a mixture of two phases: liquid and solid granules. The continuum model with microstructure is introduced, which involves two independent kinematic quantities: the velocity vector and the micro-rotation vector. The physical analogy is based on the movement of the suspension between two coaxial cylinders. The inner cylinder is stationary and the outer one rotates with constant angular velocity. This physical analogy enabled a mathematical model in a form of two coupled differential equations with variable coefficients. The aim of the paper is to present the numerical aspect of the solution for this complex mathematical model. It is assumed that the solid granules are identically oriented and that under the influence of the fluid they move translationally or rotate around the symmetry axis but the direction of their symmetry axes does not change. The solution was obtained by the ordinary finite difference method, and then the corresponding sets of points (nodes) were routed by interpolation graphics.
Intraoperatively local infiltration anesthesia in hemiarthroplasty patients reduces the needs of opioids: a randomized, double-blind, placebo-controlled trial with 96 patients in a fast-track hip fracture setting
Authors: Hofstad Janne K , Klaksvik Jomar , Wik Tina S
Published: December 2021

Background and purpose — Local infiltration analgesia (LIA) is commonly used as a component in multimodal analgesia. Pain management directed towards hip fracture patients operated on with hemiarthroplasty is often based on knowledge regarding pain treatment following elective surgery. In this elderly patient population, it is of value to clarify whether adding local infiltration analgesia (LIA) to the postoperative analgesic regimen might reduce postoperative pain or have an opioid-reducing effect.
Patients and methods — 96 hip fracture patients undergoing hemiarthroplasty in spinal anesthesia were included. All patients received a multimodal pain regimen and were randomized to receive either ropivacaine or placebo. All patients received morphine depot-opioid and morphine as rescue medication postoperatively. The primary endpoint was pain during mobilization in the recovery unit on the day of surgery. Secondary endpoints were pain during mobilization the day after surgery and postoperative opioid requirements on the first postoperative day.
Results — The levels of pain (NRS) during mobilization both in the recovery unit and on the day after surgery were similar in the 2 groups, with median 4 and 0.5 in the placebo group and median 3.5 and 1 in the ropivacaine group respectively. Total consumption of opioids on day 0 and day 1 were 4.6 mg lower in the ropivacaine group (p = 0.04). Pain during mobilization was registered for only 44 of 96 patients for several reasons, including lack of mobilization.
Interpretation — There were similar pain scores in both the local infiltration and placebo group postoperatively. However, substantially reduced opioid consumption was found in patients receiving LIA.
more comprehensive evaluation of quality of care after total hip and knee arthroplasty: combining 4 indicators in an ordered composite outcome
Authors: Van Schie Peter , Van Bodegom-Vos Leti , Van Steenbergen Liza N , Nelissen Rob G H H , Marang-van de Mheen Perla J , IQ Joint study Group For the
Published: December 2021

Background and purpose — Most arthroplasty registers give hospital-specific feedback on revision rates after total hip and knee arthroplasties (THA/TKA). However, due to the low number of events per hospital, multiple years of data are required to reliably detect worsening performance, and any single indicator provides only part of the quality of care delivered. Therefore, we developed an ordered composite outcome including revision, readmission, complications, and long length-of-stay (LOS) for a more comprehensive view on quality of care and assessed the ability to reliably differentiate between hospitals in their performance (rankability)with fewer years of data.
Methods — All THA and TKA performed between 2017 and 2019 in 20 Dutch hospitals were included. All combinations of the 4 indicators were ranked from best to worst to create the ordinal composite outcome for THA and TKA separately. Between-hospital variation for the composite outcome was compared with individual indicators standardized for case-mix differences, and we calculated the statistical rankability using fixed and random effects models.
Results — 22,908 THA and 20,423 TKA were included. Between-hospital variation for the THA and TKA composite outcomes was larger when compared with revision, readmission, and complications, and similar to long LOS. Rankabilities for the composite outcomes were above 80% even with 1 year of data, meaning that largely true hospital differences were detected rather than random variation.
Interpretation — The ordinal composite outcome gives a more comprehensive overview of quality of delivered care and can reliably differentiate between hospitals in their performance using 1 year of data, thereby allowing earlier introduction of quality improvement initiatives.
Changes in Stroke Rehabilitation during the Sars-Cov-2 Shutdown in Switzerland
Authors: Held Jeremia P. O. , Schwarz Anne , Pohl Johannes , Thürlimann Eva , Porrtmann Silvan , Branscheidt Meret , Fratian Madalina , Van Duinen Jannie , Veerbeek Janne M. , Luft Andreas R.
Published: December 2021

Introduction: Many stroke survivors require continuous outpatient rehabilitation therapy to maintain or improve their neurological functioning, independ­ence, and quality of life. In Switzerland and many other countries, the shutdown to contain SARS-CoV-2 infections led to mobility restrictions and a decrease in therapy delivery. This study investigated the impact of the COVID-19 shutdown on stroke survivors’ access to therapy, physical activity, functioning and mood.Methods: A prospective observational cohort study in stroke subjects. At 4 time-points (before, during, after the shutdown, and at 3-month follow-up), the amount of therapy, physical activities, motor func­tion, anxiety, and depression were assessed. Results: Thirty-six community-dwelling stroke subjects (median 70 years of age, 10 months post-­stroke) were enrolled. Therapy reductions related to the shutdown were reported in 72% of subjects. This decrease was associated with significantly extended sedentary time and minimal deterioration in physical activity during the shutdown. Both parameters improved between reopening and 3-month follow-up. Depressive symptoms increased slightly during the observation period. Patients more frequently report­ed on self-directed training during shutdown.Conclusion: The COVID-19 shutdown had measurable immediate, but no persistent, effects on post-­stroke outcomes, except for depression. Importantly, a 2-month reduction in therapy may trigger improvements when therapy is fully re-initiated thereafter.
Lay abstractIn Switzerland and in many other countries, the shutdown to contain SARS-CoV-2 infections led to a reduc­ed mobility and a reduction in therapy delivery. The impact of the shutdown on stroke survivors’ access to therapy, physical functioning, and mood was investigat­ed in an observational study. Before, during, and after shutdown, the amount of therapy, motor functioning, and anxiety and depression were collected. Thirty-six commun­ity dwelling subjects were enrolled at a median of 10 months post-stroke. Therapy reductions related to the shutdown were reported in 72% of subjects. This was associated with an increased sedentary time and minimal deterioration in motor functioning, which improved after reopening. Depression increased slightly during the observation. Patients more frequently reported on self-directed training during shutdown. The COVID-19 shutdown had measurable immediate, but no persistent, effects on post-stroke outcomes, except depression. In fact, a 2-month reduction in therapy may trigger improvements when therapy is fully re-initiated thereafter.
O relacjach między kooperacją i moralnością. W kierunku nowej antropologii moralności
Authors: Landowska Alina
Published: December 2021

Czy istnieją uniwersalne wartości moralne obowiązujące wszystkich ludzi? Teoria „moralności jako kooperacji” (ang. Morality-as-Cooperation, MAC) dowodzi, że moralność to zbiór biologicznych i kulturowych rozwiązań – obejmujący pomaganie krewnym, pomaganie grupie, odwzajemnianie się, bycie odważnym, powstrzymywanie się, dzielenie zasobów i szanowanie własności innych – na powtarzające się w życiu społecznym problemy kooperacyjne. Niezależnie od kultury, rozwiązania te uważane są za moralnie dobre. Dlatego siedem typów zachowań kooperacyjnych daje możliwość wyprowadzenia spójnej teorii moralności, której dotychczas brakowało antropologii.
Tomasz Wiślicz, Zelman Wolfowicz i jego rządy w starostwie drohobyckim w połowie XVIII wieku, Universitas, Kraków 2020, ss. 265, ilustracje.
Authors: Jasiewicz Zbigniew
Published: December 2021

Recenzja książki Tomasza Wiślicza pt. Zelman Wolfowicz i jego rządy w starostwie drohobyckim w połowie XVIII wieku, Universitas, Kraków 2020, ss. 265.
Relationship Between Facial Areas With the Greatest Increase in Non-local Contrast and Gaze Fixations in Recognizing Emotional Expressions
Authors: Babenko Vitaliy , Yavna Denis , Vorobeva Elena , Denisova Ekaterina , Ermakov Pavel , Kovsh Ekaterina
Published: December 2021

The aim of our study was to analyze gaze fixations in recognizing facial emotional expressions in comparison with o the spatial distribution of the areas with the greatest increase in the total (nonlocal) luminance contrast. It is hypothesized that the most informative areas of the image that getting more of the observer’s attention are the areas with the greatest increase in nonlocal contrast. The study involved 100 university students aged 19-21 with normal vision. 490 full-face photo images were used as stimuli. The images displayed faces of 6 basic emotions (Ekman’s Big Six) as well as neutral (emotionless) expressions. Observer’s eye movements were recorded while they were the recognizing expressions of the shown faces. Then, using a developed software, the areas with the highest (max), lowest (min), and intermediate (med) increases in the total contrast in comparison with the surroundings were identified in the stimulus images at different spatial frequencies. Comparative analysis of the gaze maps with the maps of the areas with min, med, and max increases in the total contrast showed that the gaze fixations in facial emotion classification tasks significantly coincide with the areas characterized by the greatest increase in nonlocal contrast. Obtained results indicate that facial image areas with the greatest increase in the total contrast, which preattentively detected by second-order visual mechanisms, can be the prime targets of the attention.
Investigating the nonlinear dynamic seismic response of double curvature arch dams under spatial and temporal excitation of heterogeneous ground motion
Authors: Andi M. , Dashti-Naserabadi H. , Beyklarian M.
Published: December 2021

One of the factors affecting the dynamic state of the dams that may cause damages to the dam is the change under the spatial and temporal Excitation of the Heterogeneous ground Motion. Therefore, in different states the stress, strain, displacement and hydrostatic pressure indices are changed and led to serious damage to the dam. In this study, Karun 3 dam is investigated which is classified as one of the double curvature arch and gravity dams. For this purpose, using ABAQUS software, these indices have been investigated and controlled and the effectiveness of indices in this dam has been investigated in nonlinear dynamic seismic state. Northridge, Kobe, Bam, Hector, Chi-Chi and Manjil earthquakes are applied to the Karun 3 Dam. The results showed that due to the large amplitude and periodicity of the near-fault mappings, under the near-field earthquake, the deformation of the Karun 3 dam is greater than the far-field fault zone. As the height of the Karun 3 Dam rises, the effectiveness of far-field earthquakes declines and near-field earthquakes show more impact on the structure. In far-field earthquakes, stress changes due to earthquakes with maximum dynamic acceleration, the relative percentage of mises stress change is 15.5% and maximum dam crest change is 68.5 mm, and for near-field earthquakes is 25% and maximum dam crest change is 100 mm.
Diagnosing arrhythmias while screening schoolchildren
Authors: D. Yu. Nechytailo
Published: December 2021

The study involved 420 children of school age. The children underwent screening determination of arterial pressure and heart rate using automatic blood pressure manometer with arrhythmias sensors. The results were specified by means of recording ECG on a portable cardiograph. The most common heart rhythm disturbances in schoolchildren were respiratory arrhythmia and bundle branch block.
Investigation of clinical - anamnestic and laboratory indexes correlation in women of early reproductive age with edematous form of premenstrual syndrome
Authors: V. V. Palapa
Published: December 2021

An investigation of interconnection between anamnestic and clinical peculiarities of premenstrual syndrome (PMC) in edematous form and hormonal homeostasis indexes in 130 women of early reproductive age has been carried out.The correlation between anamnestic data connected with mental and emotional strain, symptoms which accompany the tissues edema and progesterone, prolactin and cortisol indexes in women with PMC edematous form is traced.
Ozone therapy in treatment of patients with urolithiasis complicated calculary pyelonephritis after performing shock-wave lithotripsy
Authors: O. S. Fedoruk  , V. V. Vizniuk  , V. I. Zaytsev  , K. A. Vladychenko  , I. I. Ilyuk
Published: December 2021

35 patients were involved in a study of the effect of the use of intravenous ozone therapy within 10 days for a kidney stone disease with calculous pyelonephritis after applying the distance shock-wave lithotripsy. The positive therapeutic effects of its application, which was manifested in a decrease of lipid peroxidation products in the blood and increased activity of antioxidant enzymes has been established.
Characteristics and ways to use cord blood stem cells (review)
Authors: D. B. Dombrowskyi  , Y. R. Pshyborovska  , K. I. Yakovets  , V. V. Savin  , Y. V. Olinyk  , V. V. Maksymiuk
Published: December 2021

As a result of a review of scientific publications in this study the main advantages of stem cells isolated from cord blood are highlighted, as well as their use in treating various diseases.
Time organization of physiological functions in mammals. Cerebral structures involvement
Authors: R. Yе. Bulyk  , I. V. Herush  , V. P. Pishak  , Y. Y. Rohovyi
Published: December 2021

The results of five year research concerning the mechanism providing circadian rhythms of physiological functions of organs, in particular the kidneys, are presented in the paper. It was proved by light optical, electron microscopy, biochemical and immunohistochemical methods that structures of the organs under the study as well as their functions are strongly subordinate to the duration of the photoperiod. Depression of the pineal body activity (24 hour lighting) causes desynchronization in the structure of suprachiasmatic nucleus (SCN) neurons and in protein c-Fos synthesis. Disturbanceof the diurnal rhythm of the SCN pacemaker and of melatonin synthesis is conditioned by the change in the rhythm of epiphysis secretory cells. Besides the SCN and the pineal gland, the hippocampus neurons are involved in the photoperiod disintegration.
Modern possibilities of clinical laboratory diagnostics
Authors: I. A. Plesh  , А. I. Кshanovska  , O. Y. Khomko  , L. D. Boreiko  , O. V. Makarova
Published: December 2021

This article presents the possibilities of clinical laboratory diagnostics, development of new sections of laboratory medicine, such as proteomics and genomics, determination of tumor’s markers, supersensitive molecular genetics techniques and the importance of studying of the possibilities of clinical laboratory diagnostics on the last courses of the future doctors of different specialities.
Achievements of the researchers of Bukovinian State Medical University in investigation of phytotherapy, apitherapy, healthy nutrition problems
Authors: O. I. Voloshyn  , T. N. Boychuk  , O. I. Ivashchuk  , I. F. Meshchyshen
Published: December 2021

The article presents the results of 23 years of research by the staff of Bukovinian State Medical University on the issue of herbal medicine, apitherapy and healthy food. The expediency of further scientific research in this field and their compliance with the current international trends in medicine and pharmacy have been substantiated.
Psychological-pedagogical culture of the professors’ stuff of the higher medical educational establishment in the context of the Bologna process principles
Authors: O. M. Panko
Published: December 2021

Ukrainian society has entered the phase of reformation of higher education, including medical education, according to the standards of Bologna process. Our state faces presently the choice of new educational paradigm which aims at removing disparity between the requirements of the society and the level of educational services, at replacing the aim of comprehensive personality development with the aim of maximal development of person's abilities to self-realization and self-education. The importance of Bologna process is shown in the article; it is proven that it is an extraordinarily difficult and prolonged process, which requires, first of all, the correction of psychological and pedagogic culture of teaching staff of higher medical institutions, which is ready to reconstruct cardinally the educational process. It is difficult to overestimate the urgency of the problem, as it concerns both the education and its reformation, as well as the process of integration of our country into Europe.
Degenerative disc disease in young adults: cytokine profile and angiogenic factors
Authors: Novikova AV , Pravdyuk NG , Saklakova VS , Lolomadze EA , Feniksov VM , Nikolaev DA , Davygora KS , Timofeev VT , Shostak NA
Published: December 2021

Back pain (BP), associated with the degenerative disc disease (DDD), poses a heavy social and economic burden due to early disability and indications to surgery, emerging in young adults. Pathophysiological basis of premature intervertebral disc (IVD) degeneration is being actively studied. The study was aimed to define the profiles of inflammatory cytokines in DDD, as well as their relationship to the structural spine diseases. The molecular genetic analysis of the mRNA gene abundance in patients with BP and herniated IVD after discectomy and healthy individuals was performed by the quantitative polymerase chain reaction method. High expression of TNFα, IL17 was revealed in the IVD tissues of the affected patients (p < 0.01); the levels of TNFα and IL1β correlated with the DDD severity (r = 0.301 and 0.37; p < 0.05). Elevated expression of IL1β, IL6 was found in peripheral white blood cells (p < 0.01); the levels of IL6 negatively correlated with Modic type 1 and 2 changes (r = –0.31; p < 0.05), and the levels of IL17 positively correlated with the IVD herniation in combination with erosions of the adjacent vertebral body endplates and Modic changes (r = 0.401; p < 0.05). The expression of VEGF-А in the IVD tissues and white blood cells negatively correlated with the DDD grades (r = –0.85; p < 0.001), indicating reduced vascularization in the terminal phase of the disease. The findings on DDD demonstrate the contribution of the local low-immune inflammation, coupled with the intense disc vascularization at the earlier stages, and associated with the reactive inflammation in vertebral bodies. The results are prerequisites for developing the anti-inflammatory and reparative therapy based on the DDD grade and the presence of Modic changes in young adults with BP.
УПРАВЛЕНИЕ ПАРАМЕТРАМИ СЕЙСМИЧЕСКОЙ БЕЗОПАСНОСТИ ВЗРЫВНЫХ РАБОТ НА КАРЬЕРАХ
Authors: Сысоев Андрей , Катанов Игорь , Кондратьев Сергей
Published: December 2021

Изложены основные положения метода и описание соответствующего программного обес-

печения для прогнозирования распределения моментов инициирования скважинных зарядов

на полном промежутке времени действия взрыва при использовании неэлектрических и элек-

тронных систем инициирования. Отличительная особенность предложенного метода заклю-

чается в том, что при определении моментов времени инициирования устройств замедления

неэлектрических систем, он учитывает случайный характер срабатывания пиротехнических

составов. Дано описание программного обеспечения, позволяющего оперативно получать визу-

альную картину распределения моментов инициирования во времени, определять максималь-

ное количество зарядов, которые могут взорваться в интервале 20 мс с учетом ожидаемого

количества «наложений» срабатывания средств инициирования. Предложены рекомендации

по выбору параметров короткозамедленного взрывания, которые будет способствовать как

снижению сейсмического воздействия непосредственно при проведении массового взрыва, так и

увеличению продолжительности периодов проявления наведенной сейсмичности, характерной

для горнодобывающих территорий.
Dynamic Sensor Matching for Parallel Point Cloud Data Acquisition
Authors: Müller Simone , Kranzlmüller Dieter
Published: December 2021

Based on depth perception of individual stereo cameras, spatial structures can be derived as point clouds. The quality of such three-dimensional data is technically restricted by sensor limitations, latency of recording, and insufficient object reconstructions caused by surface illustration. Additionally external physical effects like lighting conditions, material properties, and reflections can lead to deviations between real and virtual object perception. Such physical influences can be seen in rendered point clouds as geometrical imaging errors on surfaces and edges. We propose the simultaneous use of multiple and dynamically arranged cameras. The increased information density leads to more details in surrounding detection and object illustration. During a pre-processing phase the collected data are merged and prepared. Subsequently, a logical analysis part examines and allocates the captured images to three-dimensional space. For this purpose, it is necessary to create a new metadata set consisting of image and localisation data. The post-processing reworks and matches the locally assigned images. As a result, the dynamic moving images become comparable so that a more accurate point cloud can be generated. For evaluation and better comparability we decided to use synthetically generated data sets. Our approach builds the foundation for dynamic and real-time based generation of digital twins with the aid of real sensor data.
FEATURES OF TRAINING OF FUTURE INFORMATICS TEACHERS WORKING WITH THE GIT VERSION CONTROL SYSTEM GIT
Authors: Mosiiuk Oleksandr
Published: December 2021

Teamwork is the most important soft skill of the modern specialist, not to mention a teacher. It is also undisputed that skills development is very important to start at school, in particular at computer science lessons. Accordingly, a future teacher of computer science has to know version control systems and use one of them to organize collective student's work like in class and in the process of preparing for science competitions of the Junior Academy of Sciences of Ukraine. This topic of the article is relevant because it doesn't fully describe in the scientific and methodological resources. The main goal of this article is to open the main features of teaching students to work with version control systems on the example of Git. The systematic approach was the methodological basis for the investigation discovery. But besides, the researcher analyzed, compared, and summarized the investigation and experience of the leading scientists. As the result of the article the author rise to the following conclusions that the knowledge of version control systems (in particular Git) is an important part of the preparation of computer science teachers; teaching students to work with such programs have to be combined with the study of programming; should be encouraged students to complete labs and case studies using Git; teachers have to demonstrate through examples the correct organization and culture of work with such programs. The writer is also considering using the GitHub Classroom service to organize the educational process subjects such as programming and page making of web pages.