bluuebunny/crossref_metadata_2025 huggingface dataset:
Tampilan Total Bakteri Dan Derajat Keasaman Susu Sapi Perah Akibat Dipping Dengan Menggunakan Larutan Kaporit Dengan Dosis Yang Berbeda
Authors: Sudjatmogo dan Priyo Sambodho Salwa. K. Muhidin,
Published: October 2021

ABSTRAK            Penelitian bertujuan untuk mengetahui pengaruh berbagai konsentrasi dari desinfektan (kaporit) sebagai dipping puting terhadap tampilan total bakteri dan derajat keasaman susu pada sapi Friesian Holstein (FH). Materi penelitian yang digunakan adalah 18 ekor sapi perah Friesian Holstein dengan bobot badan rata-rata 408,55 ± 30,86 kg (CV = 10,68%) dan produksi susu rata-rata 9,6 ±  0,84 L  (CV = 12,36%), desinfektan kaporit (CaHOCI) 60%, aquades dan alkohol. Perlakuan yang diterapkan adalah T1 (dipping larutan kaporit konsentrasi 0,1%), T2 (dipping larutan kaporit konsentrasi 0,2%) dan T3 (dipping larutan kaporit konsentrasi 0,3%). Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan 6 ulangan. Data yang diperoleh kemudian dianalisis menggunakan ANOVA dilanjut dengan uji BNT. Hasil penelitian menunjukkan rataan total bakteri (TPC) pada masing-masing perlakuan T1, T2 dan T3 sebesar 3,89 x 105; 3,046 x 105 dan 2,035 x 105CFU/ml (p0,01). Rataan nilai pH susu yaitu T1, T2 dan T3 sebesar 5,63; 6,15 dan 6,35 (p0,01). Kesimpulan penelitian hasil menunjukan bahwa dipping dengan menggunakan larutan kaporit sudah mampu mengurangi jumlah bakteri dan mempertahankan pH susu.Kata kunci : Dipping puting, Kaporit, Total bakteri susu, pH susu
Pengaruh Pemberian Serbuk Buah Semu Jambu Monyet (Annacardiumaccidentale L) Sebagai Aditif Pakan Terhadap Profil Serum Lemak Dan Glukosa Broiler
Authors: Retno Murwani dan  Siti Susanti Adella. C. Maharani,
Published: October 2021

ABSTRAKPenelitian ini bertujuan mengetahui pengaruh pemberian serbuk Buah Semu Jambu Monyet (BSJM) dalam aditif pakan terhadap profil serum lemak dan glukosa broiler yang memiliki arti penting pada kualitas karkas broiler antara lain kadar kolesterol darah, HDL, LDL, trigliserida dan glukosa. Penelitian dilaksanakan pada tanggal 14 Januari – 17 Febuari 2015 di kandang ayam, peternakan rakyat Ds.Kaliancar, Podorejo, Ngaliyan, Semarang dan Balai Laboratorium Kesehatan, Semarang. Materi yang digunakan adalah Day Old Chick (DOC) ayam broiler strain CP-707 sebanyak 140 ekor (unsexed) dengan bobot badan 40,00 g± 0,84.  Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap (RAL).  Perlakuan yang diuji adalah dosis serbuk BSJM terdiri atas T0 (tanpa penambahan), T1 (penambahan 0,25% serbuk BSJM), T2 (penambahan 0,5% serbukBSJM) dan T3 (penambahan 1,00% serbuk BSJM). Hasil penelitian menunjukan ada pengaruh nyata (P0,05) terhadap kadar kolesterol darah, HDL, LDL dan trigliserida, tetapi tidak berpengaruh nyata (P0,05)  terhadap kadar glukosa pada pemberian serbuk buah semu jambu monyet (Annacardium accidentale L) pada broiler. Kata kunci: serbuk BSJM, profil serum lemak dan glukosa, broiler
Hasil Tanaman Selada (Lactuca sativa L.) Akibat Pemberian Dosis Pupuk Organik Cair Sebagai Subsitusi Ab Mix Pada Sistem Hidroponik Rakit Apung
Authors: E. D. Purbajanti, dan  Sumarsono Karimah. A,
Published: October 2021

ABSTRAKPenelitian bertujuan untuk mengkaji pertumbuhan dan produksi tanaman selada (Lactuca sativa L.) terhadap pemberian dosis pupuk cair organik urin kelinci sebagai subsitusi AB Mix pada sistem hidroponik rakit apung. Penelitian dilaksanakan di Greenhouse Fakultas Peternakan dan Pertanian, Universitas Diponegoro, Semarang. Penelitian dilaksanakan sebagai percobaan Monofaktor dengan rancangan acak lengkap terdiri dari 6 ulangan. Perlakuan terdiri dari (A) AB Mix 100% sebagai kontrol, (B) POC urin kelinci 75% + AB Mix 25%, (C) POC urin kelinci 50% + AB Mix 50%, (D) POC urin kelinci 25% + AB Mix 75% dan (E) POC urin kelinci 100%. Parameter yang diamati adalah tinggi tanaman, berat basah dan berat kering total, kadar air, dan serapan N. Data diolah dengan analisis ragam dan dilanjutkan dengan uji Beda Nyata Terkecil (BNT). Hasil penelitian menunjukkan bahwa perlakuan pemberian 100% AB Mix berpengaruh nyata (P0,05)  terhadap berat basah total dan kadar air, sedangkan pada tinggi tanaman, berat kering total dan serapan N tidak berpengaruh nyata. Substitusi terendah yang masih setara dengan AB Mix 100%  adalah perlakuan 50% AB Mix + 50% POC. Kata kunci: Selada, POC, AB Mix, hidroponik, produksi.
Studi Penerimaan Konsumen Terhadap Fillet Daging Ikan Nila Gift (Oreochromis Niloticus)
Authors: M. Hadziq Qulubi  dan  Anhar Faisal Fanani Nurul Fajrih H,
Published: October 2021

ABSTRAKTujuan penelitian adalah untuk mengkaji pengaruh pemberian berbagai level tepung gembili pada fillet daging ikan nila gift terhadap tingkat kesukaan konsumen yaitu meliputi tekstur dan rasa fillet  ikan. Penelitian dirancang dengan menggunakan metode experimental RAL (Rancangan Acak Lengkap) dengan pemberian level tepung gembili yang ditambahkan kedalam pakan ikan dengan 4 perlakuan yang diulang sebanyak 5 kali meliputi: P0 : Pakan komersil tanpa penambahan tepung gembili, P1 : Pakan komersil + tepung umbi gembili 0,3% ,P2: Pakan komersil + tepung umbi gembili 0,6%, P3: Pakan komersil + tepung umbi gembili 0,9%. Data dianalisis ragam (ANOVA) dan diuji dengan uji F pada taraf 5%. Apabila terdapat perbedaan yang nyata maka dilanjutkan dengan uji wilayah ganda Duncan. Hasil penelitian menunjukkan bahwa penambahan berbagai level tepung umbi gembili pada pakan ikan tidak menunjukkan pengaruh yang nyata terhadap rasa dan tekstur daging ikan nila gift, namun secara numerik menunjukkan peningkatan. Semakin tinggi level tepung umbi gembili yaitu pada perlakuan P3, maka semakin tinggi tingkat kesukaan konsumen terhadap rasa dan tekstur daging ikan nila. Sebagai saran perlu dilakukan penelitian lebih lanjut mengenai efektivitas inulin terhadap kualitas daging ikan nila ditinjau dari aspek komposisi kimia daging berdasarkan uji laboratorium. Kata kunci: Ikan Nila Gift, Inulin umbi gembili, Fillet, Organoleptik
Peningkatan Kepadatan Kandang Berdampak Terhadap Rasio Daging Tulang dan Perlemakan Ayam Broiler
Authors: Umiyati Atmomarsono, Warsono Sarengat dan  Teysar Adi Sarjana Dewi Suhita,
Published: October 2021

ABSTRAKPenelitian ini dilakukan dengan tujuan mengkaji perubahan perlemakan dan rasio daging tulang ayam broiler akibat dari peningkatan kepadatan kandang. Materi yang digunakan yaitu 280 ekor ayam broiler strain lohman unsexed umur 15 hari dialokasikan ke dalam 20 unit percobaan dengan tingkat kepadatan berbeda. Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 5 ulangan. Perlakuan yang diberikan terdiri dari T1 = 8 ekor/m2, T2 = 12 ekor/m2, T3 = 16 ekor/m2 dan T4 = 20 ekor/m2. Parameter yang diamati yaitu rasio daging tulang, persentase lemak abdominal dan kadar lemak daging ayam broiler. Hasil penelitian menunjukkan bahwa peningkatan kepadatan kandang nyata menurunkan persentase lemak abdominal dan rasio daging tulang, namun tidak mempengaruhi lemak daging. Dapat disimpulkan bahwa peningkatan kepadatan kandang berdampak negatif terhadap rasio daging tulang dan persentase lemak abdominal pada kepadatan 20 ekor/m2 sehingga berpengaruh menurunan rasio daging tulang dan diikuti penurunan persentase lemak abdominal tanpa mempengaruhi kadar lemak daging.                                                                                                          Kata kunci : Kepadatan kandang, rasio daging tulang, lemak abdominal, lemak daging
La liberte d'expression pourquoi faire? De l usage democartique de cette liberte publique
Authors: MILACIC SLOBODAN
Published: October 2021

L'étude traite la problématique de la liberté d'expression dans un contexte complexe,
juridique, philosophique, politique, conjointement avec d'autres principes et
droits fondamentaux, tels que l'égalité et la liberté individuelle. De ce point de
vue, la conclusion de l'étude est que l’usage politique, en général, mais surtout
médiatique, de la liberté d’expression présente beaucoup d’aspects
problématiques par rapport à notre modèle référentiel de la démocratie
politique, libérale et juridique. Or, le destin global de notre système dépend du
bon équilibre entre la démocratie collective et les libertés individuelles; entre le
politique et le juridique.
The german separation between police and the offices for the protection of the Constitution. Legal framework
Authors: TIMU CODRIN , IBLER MARTIN
Published: October 2021

“The rule of law and the federal state, as well as the protection of the fundamental
rights could forbid the fusion of certain offices or the delegation of these offices
with functions that are incompatible with their constitutional position“1. In this
manner the Federal Constitutional Court of Germany mentions the separation
between police and the offices for the protection of the constitution. After the
terrorist attacks in the USA, Spain, France, Belgium and Germany, the
teamwork between the state offices has kept on intensifying. The discussion
(debate) about the legal framework of the separation principle continued
however to exist. In a time, where the security of the citizens steals away the
space of the fundamental rights, to treat this subject is of the utmost
importance2, in order not to allow the recurrence of the mistakes of the Weimar
Republic. The article deals with the legal framework of the German separation
between police and the offices for the protection of the constitution and gives
an answer to the question if this principle has a constitutional status.
The prerogative writs - indian perspective
Authors: PATHAK HARSH
Published: October 2021

The Constitution of India broadly provides for five kinds of “prerogative” writs: habeas
corpus, certiorari, mandamus, quo warranto and prohibition. This study
presents their legal status, namely their application, procedure and grounds for
their application.
The study concludes that, in India, the rule of law is supreme and judiciary has
the right to interfere whenever there is deviation from this supremacy. The
judiciary shall ensure that all administrative actions comply with legal limits
and consider administrative measures to assess whether the authority has
exercised powers, the authority misused or exceeded its powers, the authority
committed an error of law, the authority violated principles of impartiality of
the judiciary, the authority has violated the fundamental rights of individuals.
The Judiciary stands to ensure that all administrative actions are confined to
the limits of the law and examines administrative action to assess whether the
authority has exercised its powers, whether the authority has abused or
exceeded its powers, whether the authority has committed an error of law,
whether the authority has violated the principles of natural justice, whether the
authority has infringed the fundamental rights of persons.
Hypoglycemic Activities of Ethanolic Leave Extract of Acalypha Wilkesiana in Streptozotocin-Induced Diabetic Wistar Rats
Authors: A. O. Iyamu , H. O. Otamere , U. Akpamu , I. Nwadike , O. U. Njoku , L. A. Ezeanyika
Published: October 2021

Diabetes is a rampant metabolic disorder of insulin deficiency or resistance. In support of the alternative therapy quest, this study investigates the antidiabetic actions of ethanolic leave extract of Acalypha wilkesiana (A. wilkesiana) in diabetic rats. The study was conducted in 3 phases using streptozotocin (50mg/kg) induced diabetic adult Wistar rats. In phase one, 18 diabetic rats were divided into 3 groups (n=6) and treated with distilled-water (10ml/kg), glimepiride (0.1mg/kg) and ethanolic leave extract of A. wilkesiana (250mg/kg) respectively. On separate 18 diabetic rats (phase two), 5% glucose (10ml/kg) was administered after treatments as in phase one. Blood glucose was measured at 0 and 30-minute intervals for 180 minutes in both phases. On another 18 diabetic rats (phase three), similar treatments were given daily for 14 days. Blood glucose was measured at day 0, 3 days after induction, 3, 7, 10, and 14 days treatments. ANOVA was carried out with p <0.05 as significant. The results showed progressively hypoglycemic actions significant from the 90th minute with glimepiride (285.17±12.09mg/dl) and the 120th minute with the extract (279.83±14.88mg/dl) through 180 minutes compared to control in 1st-phase. There was a significant obliterating effect on glucose-induced hyperglycemia in a time-dependent manner at 90th through 180th minutes after glucose loading in glimepiride and extract-treated groups compared to control (2nd phase). Streptozotocin-induced decreased body weight was improved in glimepiride and extract-treated groups by days 7 and 14 and there was a significant steady duration-dependent decrease in blood glucose from the 3rd to 14th day of treatments compared to control. The findings suggest that ethanolic leaves extract of A. wilkesiana possesses antidiabetic action probably through stimulation of pancreatic β-cells or improves insulin action.
Kelimpahan Dan Keanekaragaman Jenis Ikan di Perairan Ndalir Kabupaten Merauke, Papua
Authors: Saleky Dandi , Weremba Efraim , Welikken Marius A.
Published: October 2021

This study aims to analyze the diversity of fish species caught on the Ndalir Coast of Merauke Regency. This research was conducted in Juli-August 2020. The determination of the sampling points at the research location used the purposive random sampling method with two observation stations. Analysis of the research data using relative abundance (Kr), Shannon-Wienner index (H '), uniformity index (E), and dominance index (C), The number of fish catches during the study time was 431 which were divided into 12 species of fish. Station two has a greater number of catches than station one. The highest relative abundance was tongue fish (Cynoglossus abbreviation) (Station I) and mullet (Mugil cephalus) (Station II). The diversity index value at the two observation stations is in the medium category. The uniformity and dominance index values ​​show that the species at the two research stations are evenly distributed with no dominating species.
Purifying the Religion: An Analysis of Haram Targeting among Salafi Jihadi Groups
Authors: Siroky David S. , Souleimanov Emil Aslan , Ratelle Jean-François , Popovic Milos
Published: October 2021

Islamic law denotes as haram any forbidden behavior, object, beverage, or food. Despite subscribing to a similar Salafi ideology, very few jihadi groups use violence against haram targets (e.g., brothels, casinos, statues, liquor stores, mixed sex schools, and gay clubs). This study
argues that haram-centered violence unites ethnically-mixed jihadi groups by fostering a superordinate Islamic identity that enables them to overcome their collective action problems. As a result, ethnically-mixed Salafi jihadi groups deploy haram targeting much more than homogenous ones.
Using new disaggregated group-level data, our analyses demonstrate that the ethnic structure of Salafi jihadi groups shapes haram targeting, both in Dagestan and on a global scale. The article discusses these findings and directions for future research on religious violence.
PENINGKATAN KEMAMPUAN BERPIDATO DI DEPAN KELAS DENGAN MENGGUNAKAN METODE PEMBELAJARAN TERBALIK BAGI SISWA KELAS IX A SMP NEGERI 5 KOTA BENGKULU
Authors: SILISMI ELVI
Published: October 2021

Penelitian ini bertujuan untuk mendeskripsikan apakah penggunaan metode Pembelajaran Terbalik dapat meningkatkan kemampuan berpidato siswa kelas IXA SMP Negeri 5 Kota Bengkulu. Penelitian di laksanakan pada semester genap tahun pelajaran 2020/2021. Subjek penelitian terdiri dari 26 siswa kelas IX A SMP Negeri 5 Kota Bengkulu. Penelitian ini dilatar belakangi oleh rendahnya minat, keaktifan dan kemampuan berpidato siswa di depan kelas. Penelitian tindakan kelas dilaksanakan sebanyak 2 siklus. Tiap siklusnya terdiri dari 4 tahap, yakni perencanaaan, pelaksanaan, observasi, dan refleksi. Instrumen yang digunakan merupakan lembar tes hasil belajar yang di berikan sebelum tindakan/ pratindakan dan setelah tindakan lembar observasi dan lembar kerja kelompok. Pengumpulan data dan pengolahannya berdasarkan data yang didapatkan pada instrumen tersebut. Penggunaan metode Pembelajaran Terbalik dapat meningkatkan kemampuan berpidato di depan kelas siswa kelas IXA SMP Negeri 5 Kota Bengkulu. Peneliti menggunakan pendekatan kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa siswa menjadi semakin terampil berpidato di depan kelas dengan bahasa yang baik, benar dan santun. Siswa tampil di depan kelas sudah memperhatikan aspek-aspek berpidato yang baik seperti ketepatan ucapan/lafal, penempatan tekanan/intonasi, pilihan kata, kelancaran berbicara, penguasaan topik,dan kerelevansian. Pada pratindakan jumlah siswa 26 siswa yang tuntas hanya 2 siswa (07,69%.) Pada siklus 1 siswa yang tuntas 9 siswa (34,61%), siswa yang belum tuntas 17 siswa (65,38%). Nilai siswa tertinggi 85, dan nilai siswa terendah 59. Sedangkan pada siklus 2 siswa tuntas 23 siswa (88,46%) siswa belum tuntas 3 siswa (11,53%). rata-rata nilai meningkat dari 69,53 menjadi 85,53 dengan nilai tertinggi 96 sedangkan nilai terendah 78. Dapat disimpulkan bahwa tingkat keberhasilan pada siklus 1 belum berhasil sedangkan pada siklus 2 sudah berhasil. Hal ini berarti, bahwa Metode Pembelajaran Terbalik untuk pembelajaran berpidato di depan kelas siswa kelas IX A SMP Negeri 5 Kota Bengkulu sangat tepat dan berhasil.
PENGGUNAAN PENDEKATAN INKUIRI MELALUI PENGAMATAN UNTUK MENINGKATAN MINAT DAN PRESTASI BELAJAR SISWA KONSEP REAKSI KIMIA KELAS VII H MTsN 7 KEDIRI
Authors: MUTHORIKAH SITI
Published: October 2021

Kurikulum 2013 (K-13) membawa konsekuensi logis pada upaya peningkatan kualitas proses pembelajaran IPA yang disesuaikan dengan karakteristik dan lingkungan sekitar madrasah. Pembelajaran menekankan pada pemberian pengalaman secara langsung kepada siswa untuk memahami gejala yang terjadi sehingga dalam pelaksanaannya dibutuhkan strategi pembelajaran yang tepat. Oleh sebab itu, maka kami menyusun pembelajaran dengan pendekatan inkuiri melaui pengamatan untuk meningkatkan minat dan prestasi belajar siswa kelas VII H MTsN 7 Kediri. Penelitian yang kami lakukan adalah penelitian tindakan kelas yang terdiri dari dua siklus tindakan. Setelah dilakukan análisis dan refleksi pada siklus I, diperoleh data 72,5% siswa aktif dalam pembelajaran. Sedangkan pada siklus II meningkat menjadi 90%. Sementara rata-rata hasil belajar siswa pada siklus I adalah 84 dan meningkat menjadi 91,5 pada siklus 2. Sehingga dari data tersebut dapat disimpulkan bahwa pendekatan inkuiri melalui pengamatan dapat meningkatkan minat dan belajar siswa pada konsep reaksi kimia
DESCRIPTION OF CLINICAL AND PARACLINICAL RESULTS OF LAPAROSCOPIC RETROPERITONEAL RESECTION OF BENIGN ADRENAL ADENOMA AT VIET DUC FRIENDSHIP HOSPITAL IN 2018
Authors: Nhung Nguyen Thi , Anh Le Tuan , Tuan Anh Hoang Khac
Published: October 2021

The study was conducted with objectives: Describe the clinical and paraclinical results of laparoscopic retroperitoneal resection of benign adrenal tumors at Viet Duc Friendship Hospital in 2018 on 67 patients diagnosed as benign adrenal tumor and was treated with retroperitoneal endoscopic surgery at Viet Duc hospital in 2018. The study design was retrospective.  Results: The clinical syndromes of the patients were mainly Cushing's syndrome (3%), Conn's syndrome (29,8%), Pheochromocytome (17,9%) and 49,3% of patients with nonsecretory tumors. . Specific biochemical tests: hypercortisolemia (4,48%); increased blood catecholamines (16,42%) and increased urinary catecholamines (14,93%). Ultrasound: The average tumor size was 20.37 ± 16.05mm; The diagnostic sensitivity was 74,6%. CT or MRI: The mean tumor size was 26.63 ± 12.7mm; highly sensitive and is the gold standard on diagnostic imaging. Conclusion: The clinical and laboratory results of patients undergoing laparoscopic resection of benign adrenal tumors are highly sensitive.
STUDY THE ISOLATION RATE AND ANTIBIOTIC RESISTANCE OF ACINETOBACTER SPP IN THE INTENSIVE CARE DEPARTMENT THANH NHAN HOSPITAL
Authors: Loan Nguyen Thi , Huyen La Thi , Hien Nguyen Minh
Published: October 2021

Objectives: To describe the isolation rate and antibiotic status of Acinetobacter ssp hospital-acquired bacteria in the intensive care unit. Methods: 1434 patient samples isolated patient samples, cultured, performed antibiogram, described cross-section. Results: 109/331 strains of Acinetobacter spp were isolated (32.9%) and mainly from respiratory specimens, catheters (76.1% and 14.7%). Acinetobacter spp has a high degree of antibiotic resistance to most of the antibiotics Ceftazidime: 91.7%, Cefepime 91.7%, gentamycine 91.7%, Amikacin 83.3%, Imipenem and Meropenem 75%, still sensitive 100 % with antibiotics Polimycin B and Colistin.
THE SITUATION OF ANTIBIOTIC TREATMENT OF COMMUNITY PNEUMONIA IN CHILDREN
Authors: Tuong Dinh Nguyen , Hiep Bui Tung , Mai Do Van , Phuc Nguyen Huu
Published: October 2021

Objective: To investigate the situation of antibiotic use in the treatment of community pneumonia in children at Can Tho Children’s Hospital. Subjects and methods: Retrospective-descriptive study on 140 children diagnosed with community pneumonia, hospitalized for treatment at Can Tho Children’s Hospital from October 2020 to December 2020. Results: 55.71% of patients were taking antibiotics before hospitalization. Antibiotics used the most to treat pneumonia at hospital were penicillins/betalactamse inhibitors, accounting for 44.44%. For pneumonia patients, the rate of choosing the single regimen for initial treatment was 89.47% and the combination regimen was 10.53%. For patients with severe pneumonia, the rate of choosing of single regimen had decreased to 74.14%, while the choice of combination regimen had increased to 25.83%. The average number of regimen changes during treatment was 1.43 ± 056 times. The main reason for the change in the regimen was improved clinical symptoms (43.75%). The average duration of treatment with antibiotics was 6.48 ± 0.71 days. The duration of treatment as well as the duration of antibiotic use increased with the severity of the disease. Conclusion: The most commonly used antibiotics for treating commnity pneumonia at hospital were penicillins/betalactamse inhibitors. For pneumonia patients, a single regimen (89.47%) and a combination regimen (10.53%) was chosen. For patients with severe pneumonia, the choice of the single regimen decreased to 74.14%, the combination regimen increased to 25.83%. The main reason for the modification of the regimen was the improvement of clinical symptoms. The duration of treatment as well as the duration of antibiotic use increased with the severity of the disease.
CHROMOSOMAL DEFECTS IN INCREASED NUCHAL TRANSLUCENCY FETUS
Authors: Long Nguyen Hai , Cuong Tran Danh , Anh Ngo Toan , Cuong Le Pham Sy , Huong Nguyen Thi Thu , Tinh Phan Thi , Linh Nguyen Duy , Viet Nguyen Xuan , Dao Chu Quang , Hoang Vu Huy
Published: October 2021

Objectives: Determination of the prevalence of all chromosomal defects and its distribution in fetuses with increased nuchal translucency thickness. Methodology: This is a retrospective study among pregnant women indicated for amniocentesis by nuchal translucency above 2.5 mm and consent to the study. 2720 cases were included to the study during 6 years’ period from 2015 to 2020. All singleton pregnancies whose nuchal transluciency measurements were equal or over 2.5mm, were indicated for amniocentesis. Results: The study was consist of 2720 amniocentesis in which fetal nuchal transluciency was elevated. The median maternal age was 29.19 years old (range 17-46), and the median fetal crown-rump length was 66.9 mm (range 45– 84). The fetal karyotype was abnormal in 560 (20.6%) pregnancies. The popular chromosomal conditions were including trisomy 21(55%), trisomy 18 (11.2%), trisomy 13 (3.9%), 45, XO (2.7%). Chromosomal aberrations rate was 17.6% at maternal age of 30- 34, 34% and 50.0% at maternal age of 35- 39 and ≥ 40 respectively. Conclusion: In fetuses with increased nuchal translucency, more than a half of the chromosomal aberrations were trisomy 21 (55.0%). Structural rearrangements were 22.5%. Advanced maternal age (above 35) increases the risk of chromosomal aberrations.
THE RATE OF RESIDUAL NEUROMUSCULAR BLOCKADE AFTER LAPAROSCOPIC APPENDECTOMY SURGERY AT NGUYEN TRI PHUONG HOSPITAL
Authors: Nhut Doan Minh , Chinh Nguyen Van
Published: October 2021

Introduction: In Vietnam, using a muscle accelerator to measure the TOF index to monitor residue neuromuscular blockade has not been performed routinely, extubation is mainly based on subjective clinical assessments.

Methods: A cross-sectional study on 96 patients undergoing laparoscopic appendectomy at Nguyen Tri Phuong Hospital, from November 2020 to May 2021.

Objectives: The study was conducted with 2 objectives including (1) Determine the progression of TOF index at 7 time points: immediately after arriving in the recovery room, after extubation, 15 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes after extubation; (2) Determination of residual muscle relaxant rate of patients undergoing laparoscopic appendectomy at Nguyen Tri Phuong Hospital.

Results: The average TOF ≥ 0,9 index after laparoscopic appendectomy at the time of resuscitation was 88.11%, extubation was 90.53% and at 120 minutes after extubation. is 99.88%. Residual muscle relaxation after surgery when TOF index < 0.9. At the time of resuscitation, the highest residual rate of muscle relaxant accounted for 58.33%, followed by the time of extubation 39.58%, 15 minutes after extubation was 21.88%. Until 120 after extubation, there is no case that has residue neuromuscular blockade.

Conclusion: Through the study results, it is necessary to monitor patients undergoing laparoscopic appendectomy with quantitative devices to more accurately assess the clinical index of muscle relaxation.
PHYSICAL HEALTH STATUS OF PEOPLE AGED 60 YEARS AND OVER AT NURSING CLUBS IN DISTRICT 10, HO CHI MINH CITY
Authors: Tri Nguyen Manh , Van Le Thi Tuong , Vinh Luong Thai , Ha Vo Thi Ngoc , Phuong Nguyen Thi , Van Nguyen Thi
Published: October 2021

Background: The age of support and endurance against external and internal factors and agents is greatly less so that the need for health care including physical and mental training to improve the quality of life is essential especially the physical health of the elderly.

Target:. Determination of physical health scores and associations of people aged 60 years and older at nursing clubs in District 10, Ho Chi Minh City, in 2019.

Methods and materials: Descriptive cross-section study. People aged 60 years and over who have been training at nursing clubs living in District 10, Ho Chi Minh City were surveyed from September 2018 to October 2019.

Results: The study showed an average score of 63.3 in ±17.3 points. In particular, physical activity: 61.0±23.1; physical limitations: 57.2±26.1; pain sensation: 68.2±22,2; general health: 59.6±14.9. Considering the relationship, as the age group increases, the mean score of the elderly's quality of life decreases statistically significantly in four áreas (p<0,05). Women have a statistically significantly higher mean score on quality of life than men (p<0,05).

Conclusions: The results of the study are important information that informs the physical health status of elderly people aged 60 years and older, and suggests recommendations in improving the quality of physical health care of the elderly.
THE CURRENT SITUATION OF TOBACCO ATTRACTION AND FACTORS RELATED TO TOBACCO CONSULTANT SERVICES, SMOKING CESSATION SERVICES AMONG PATIENTS WITH CHRONIC LUNG DISEASE AT MEDICAL CENTER NGA NĂM, SOC TRANG PROVINCE IN 2020
Authors: Dao Nguyen Thi , Thu Tran Thi Ngoc , Thuy Phan Ngoc , Nguyen Nguyen Thi Hong , Duyen Nguyen Thi Mai
Published: October 2021

Objectives: Determination rate of smoking and some  related factors to the accessibility of counseling and smoking cessation services in patients with chronic lung disease at Nga Nam Medical Center, Soc Trang in 2020.

Subjects and research methods: Cross-sectional descriptive study with analysis. The toolkit is based on “The Ministry of Health’s 2018 Tobacco Harm Prevention Guidelines” and related research.

Results and discussions: The smoking rate of patients is 59.9%. The number of people accessing tobacco cessation counseling services is lowing with 29.9%. The results of multivariate logistic regression analysis showed that have relationship between the ability to access counseling services, smoking cessation and smoking (OR = 0.042; p < 0.005), gender (OR = 0.067; p < 0.005), occupation (p < 0.005).

Conclusions and recommendations: Patients need to actively learn about the harmful effects of smoking as well as smoking cessation methods and services. The health sector needs to develop plans and provide counseling and smoking cessation services for patients. When educating, it is necessary to pay attention to the patient's psychology, gender and occupation.
QUALITY OF LIFE AND SOME RELATED FACTORS IN BRAIN INJURY PATIENTS DUE TO LAND TRAFFIC ACCIDENTS AFTER DISCHARGING AT NINH BINH PROVINCIAL GENERAL HOSPITAL IN 2018
Authors: Hien Luong Xuan , Tien Nguyen Quoc , Phuong Tran Thi
Published: October 2021

This is an epidemiological study through a retrospective review of 215 medical records of patients with brain injury due to land traffic accidents treated at Ninh Binh Provincial General Hospital. Research results show that among the 5 factors of the scale measuring quality of life in Vietnam, the factor of anxiety and sadness was the least recorded by patients. Up to 96.5% of subjects did not feel the presence of this factor.Up to 42.7% of the subjects felt a little element of pain and discomfort. Married people living with family had higher quality of life scores than single or separated/divorced people. The older the age group, the lower the mean score of quality of life (p<0.05). People with higher incomes had higher quality of life scores than those with lower incomes (p<0.05).
THE EFFECTIVENESS OF MICRONUTRIENT SUPPLEMENTATION ON ZINC DEFICIENCY, VITAMIN A DEFICIENCY AMONG ADOLESCENT GIRLS IN MOUNTAINOUS HIGH SCHOOL IN THANH HOA PROVINCE IN 2019 - 2020
Authors: Hang Luu Kim Le , Nga Tran Thuy , Phuong Nguyen Thi Lan , Hiep Nguyen Xuan
Published: October 2021

A community intervention study with a placebo group, double-blind, evaluating the effect of using multi-micronutrient tablets on zinc deficiency, vitamin A deficiency among adolescent girls in mountainous high school in Thanh Hoa province in 2019 - 2020, using WHO and IZiNCG classifications. A double-blind randomized controlled trial was conducted among 322 school girls randomly divided into 2 groups. The multi-micronutrient supplements consist of 23 vitamins and minerals, including zinc (10.8 mg), vitamin A (550mcg), while the placebo group took a placebo tablet, once a week for 9 months. All of the children were dewormed by Albendazole 400 mg at baseline. Results showed that after 9 months of intervention, the mean serum zinc concentration of the intervention group (11.35 ± 2.88 µmol/l) was significantly improved and significantly higher than that of the Control group (10.51 ± 2.08 µmol/l) with p<0.05. The retinol concentration did not show significant difference between the two groups, but there was a significant improvement compared to the baseline time the intervention group with an increase level of 0.07 ± 0.30 mol. /l. After the intervention, the rate of zinc deficiency, sub-clinical vitamin A deficiency was not statistically significant between the two groups.
SOME CHARECTERISTIC EPIDEMIC OF HEARING LOSS CHILDREN UNDER 3 YEARS OLD IN NATIONAL CHILDREN HOSPITAL IN 2018-2019
Authors: Thiem Vu Dinh , Ha Lai Thu , Phuc Phan Huu
Published: October 2021

A cross-sectional descriptive study was conducted on a group of 461 hearing impaired children who were diagnosed and treated at the Audiology and Speech language therapy centre at the National Children Hospital from January 2018 to August 2019. The purpose of the study is to assess the distribution of children by age group, gender, degree of hearing loss, high risk factors of hearing loss, and status of intervention in this group of children. Data were taken by using questionnaires and analyzed using Stata software. The results showed in the study group, there were 281 boys and 180 girls. Children with profound hearing loss have the highest rate with 58.4%, followed by the severe (11,9%) and the moderate to severe (6,9%). ANSD accounts for 16.7%. The majority of children with hearing loss in both ears (90,5%), only 9,5% children with hearing loss in one ear. The most common age at which children with hearing loss are detected is 13-24 months (33,2%). Among ANSD children, 73,6% had a history of jaundice in the newborn period. Only 17,6% of children had hearing aids and 8,9% of children with severe to profound hearing loss had cochlear implants.
CHARACTERISTICS OF WORK RELATED MUSCULOSKELETAL DISORDERS IN COMANDOS
Authors: Ben Nguyen Huu , Manh Phan Van , Hoan Bui Duy , Phong Vu Quang , Khoi Nguyen Van , Phuong Nguyen Minh
Published: October 2021

Objective: To describe the characteristics of work related musculoskeletal disorders in commandos. Subjects and methods: A cross-sectional descriptive study on 1,500 servicemen of the comando forces participating in the investigation of musculoskeletal disorders. Results: The prevalence of chronic musculoskeletal pain (in 12 months) was 60% of which the pain was mainly found in the nape, shoulder and lower back. Chronic musculoskeletal pain having to leave work only had a low rate (17,73%), most in the lower back with 9.40%. The nape and lower back had the highest rate of acute musculoskeletal pain, 21.40% and 21.27%, respectively. The Comandos soldiers worked mainly in standing and sitting positions. High REBA scores associated with musculoskeletal pain in the neck, elbows, wrists or hands, upper and lower back, thighs, and knees. Conclusion: The rate of musculoskeletal disorders in the commandos was 60%, of which the nape, shoulder, and lower back are the areas with the highest rate of musculoskeletal pain. Standing and sitting are the two main working positions of commandos. High REBA scores are associated with musculoskeletal pain in commandos.
Implementation of the Spirituality of Saint Francis of Assisi in the Life of the Brotherhood in Franciscan Missionary Sisters of Assisi Simalingkar B Medan
Authors: Waruwu Ermina , Sianipar Imelda
Published: October 2021

Spirituality is a trasendental relationship and the creation of unity relations between nature and humans, the universe and unity between individuals and God. The formulation of the research problem is how to implementation of the Spirituality of Saint Francis of Assisi in the life of the brotherhood in Franciscan Missionary Sisters of Assisi Simalingkar B Medan. The purpose of the study was to explain the findings of the implementation of the spirituality of SFA in the life of the brotherhood in SFMA Simalingkar B Medan. The design of the research used is qualitative research using analytical procedures that produce descriptive-qualitative data. The sample technique used to determine the informant is a snowball sampling technique consisting of 10 SFMA sisters. Primary data sources come from interviews, observation and documentation. The results of the study were analyzed using milles and hubberman models were data reduction, data presentation, the drafting of conclusions. Stages of research, namely data transcription, data identification, data classification, data interpretation, data description. The technique used to ensure the level of data validation is triangulation, examination of colleagues, and auditing. The results are SFMA sisters have made Christ the center of living in brotherhood in the community. This brotherhood is turned on by the sabda and is supported by various prayer practices. Brotherhood among the sisters based on the love of the gospel while still prioritizing the attitude of accepting, aware of the similarities between one and the others, namely together with total. Open each other, understand each other and willing to sacrifice. This spirituality implementation is expected to remain maintained because of this spiritual implementation as the basic capital in fulfilling the call as a religus.

Keywords: Spirituality, Saint Francis of Assisi, Brotherhood, Franciscan Missionary Sisters of Assisi.
Methyl Gallate Mitigates Doxorubicin-Induced Peripheral Cytopenias:
A Preclinical Experimental Study
Authors: Ahmed Akheruz Z. , Shetty Prakashchandra , Satyam Shakta M. , D’Souza Melanie Rose , Herle Archana M , Singh Varun K.
Published: October 2021

Myelosuppression by doxorubicin is a life-threatening adverse effect in cancer patients undergoing chemotherapy. Methyl gallate is an antioxidant found in a variety of plant species. The study aimed to demonstrate the protective role of methyl gallate on doxorubicin-induced cytopenias in Wistar rats. The animals were prophylactically treated with two different doses of methyl gallate (150mg/kg/day and 300mg/kg/day) orally for seven days. Doxorubicin (25mg/kg; single dose) was administered through intraperitoneal route on the seventh day to induce cytopenias. Blood was collected 24 hours after the administration of doxorubicin and complete blood counts were estimated. There was significant (p≤0.05) development of peripheral cytopenias in doxorubicin treated control rats compared to normal saline treated control rats. Methyl gallate at both the doses significantly (p≤0.05) mitigated doxorubicin induced cytopenias compared to doxorubicin treated control rats. The findings of the present study revealed that methyl gallate has protective role in doxorubicin-induced cytopenias in Wistar rats. Following clinical studies, methyl gallate may serve as a viable alternative to growth factors in patients undergoing chemotherapy.
Pharmacological Activities of Phytoconstituents and Essential oil obtained from Cymbopogon citratus Linn.
Authors: Upadhyay Prabhat Kumar , Dixit Prakhar , Garabadu Debapriya
Published: October 2021

Cymbopogon citratus (Lemon grass) is well known medicinal herb and distributed in various regions of tropical countries South East Asia. The various parts such as leaves and whole plant of lemongrass are used in the herbal therapies. The essential oil consists of mostly terpenes, aldehyde, ketones, alcohol and esters. Cymbopogon citratus possesses wide range of pharmacological activities including antibacterial, antifungal, antidiarrheal, antifilarial, anti-amoebic and anti-inflammatory. In addition to them, antimalarial, antimycobacterial, hypoglycemic antioxidant, antimutagenicity, and CNS activities were reported. The secondary metabolites like saponins, tannins, anthraquinones, flavonoids, alkaloid phenols and also active constituents from essential oil (such as citral, limonene and terpineol) obtained from the plant are responsible for pharmacological activities. The antioxidant properties of lemongrass help in lowering the risk of cancer through scavenging of free radicals. In this paper, the study emphasizes on systematic study on the potential benefits of plant in the management of various diseases. Therefore, the phytoconstituents and major active constituents from essential oil, determines medicinally properties of lemon grass. The possible mechanisms of action has also been explored in case of some diseases.
Hydrodynamically Balanced Capsule of Famotidine: An Improved Delivery via Gastroretentive Hydrogels
Authors: Kumar Ritesh , Gohil Kashmira J.
Published: October 2021

Objective: The aim of the present study was to increase the absolute bioavailability of famotidine, enhanced patient compliance in the treatment of peptic ulcer by increasing its gastric residence time and controlled local release of drug upto 12 hours. Materials and Methods: Hydrodynamically balanced capsules of famotidine were prepared, consisting of floating matrix granules, which formed hydrogels. Effects of different formulation variables namely hypromellose (HPMC 4000 cps, HPMC 5600 cps, HPMC 15000 cps), effervescent agent (potassium bicarbonate) and mixing time were studied. Optimization study included 23 full factorial design with t50% and t80% as the kinetic parameters (response variable). Matrix characterization included scanning electron microscopy. All prepared formulations were evaluated to various parameters such as micromeritics properties, % buoyancy and in vitro drug release studies. Results and Discussion: The optimized formulation (F4) remains buoyant for more than 12 hrs. The in-vitro drug release study indicated that increasing the viscosity of HPMC resulted in sustained drug release with long floating duration. SEM studies showed definite entrapment of the drug in the matrix and hydrogel formation. Results showed a pH independent but polymer viscosity dependent drug release profile. The release kinetics followed Higuchi model and mechanism of release was found to be non-Fickian diffusion. Conclusion: Famotidine-loaded hydrodynamically balanced capsules were successfully prepared and prove to be useful for prolonged gastric residence of the drug, better bioavailability, patient compliance and improve delivery for enhanced anti-ulcer activity.
Eucalyptus sideroxylon A. Cunn.:
A Natural Eucalyptol (1,8-cineole) source in Morocco
Authors: Koursaoui Loubna , Satrani Badr , Ghanmi Mohamed , Cherrad Sara , Jaouadi Imane , Hajib Said , Aouane El Mahjoub , Chaouch Abdelaziz
Published: October 2021

The main objective of this work is to determine the effect of the harvest period on the yield and chemical quality of the essential oils of the Eucalyptus sideroxylon A. Cunn. leaves of the Mamora forest, Dayet Zerzour Bnifdel region, Rabat. Essential oil yields are remarkably high above 2.3%, with an ultimate rate of 5.48% for the month of April. The chemical quality of these essential oils is characterized by the presence of two major monoterpenes, 1,8-cineole (eucalyptol) and α-terpineol, which are proportionally inverted in terms of quantity. During the wet months between September and March, the cineole predominates with levels ranging from 72.67% to 86.11% and the other dry months are characterized by an increase of α-terpineol rate from 12.05% to 25.61%. This inverted chemical variability reveals a change in the orientation of cineole and α-terpineol biosynthesis under the control of climatic factors. This work allows us to discern favorable periods for the harvest of Eucalyptus sideroxylon leaves in terms of yield and quality of essential oils.
Formulation, Development and Evaluation of in-situ Periodontal Gel Containing Ofloxacin
Authors: Baghwan R. R. , Ambekar A. W. , Tamboli S. S.
Published: October 2021

In-situ gel forming formulations are a novel concept of providing drugs to individuals as a liquid dosage form yet achieving sustained release of the drug for the required duration. Different polymer based distribution schemes have been created that can boost the residence time of the product at the drug absorption location. These formulations exist as a flowing system before administration and at the physiological environment it gets converted into viscoelastic gel. The available therapies are to minimize the bacterial infection and to regenerate the damage done by infection and inflammation. The therapies involve systemic therapy, conventional therapy, as well as local therapy. Aim of the present work was to formulate in-situ gel of ofloxacin and it is evaluated for antibacterial activity and stability and it showed good antibacterial activity for both gram positive and gram negative microorganisms and was stable at refrigerated temperature over three months. The results indicated that the formulation could be utilized to maintain the localized drug concentration for a longer period and increase patient compliance with lesser adverse effects.
Effects of Virgin coconut oil on Testicular toxicity induced by Cadmium in rats
Authors: Lokesh Sanjana Basavanahally , Kini Rekha D , Arunkumar Nayanatara , Shetty B Sneha , N Anupama , K Bhagyalakshmi
Published: October 2021

One of major threat to the environmental pollution is the contamination the by various heavy metals. Cadmium is found to have toxic effects on testis. VCO is increasingly getting the reputation of being the most versatile and healthiest antioxidant. Objective: To study the effect pre-treatment of virgin coconut oil in cadmium induced testicular toxicity in rats. Materials and methods: Institutional ethics committee clearance was obtained before beginning the experiments. Male rats of wistar strain approximately 150-200 gm body weight was used. They were housed in the central animal house under controlled conditions of temperature and light with normal rat feed and drinking water. Animals were divided into four groups with 6 rats in each group. Sperm count and sperm morphology was done. One of the testis was used for histopathological study. The data was expressed as mean  SD. Significance of the test was set at p<0.05. Results: In the present study administration of cadmium chloride showed a significant decrease in the testicular and epididymal weight as well as sperm count and testosterone level and increase in sperm shape abnormality. Pre-treatment with Virgin coconut oil showed a significant increase in the testicular and epidydimal weight as well as sperm count and testosterone level and decrease in sperm shape abnormality Testicular section in normal control rats and Virgin treated rats showed normal features. But, in cadmium treated rats the testis showed necrosis of most of the tubules but rats pre-treated with virgin coconut oil showed that less than 25 % of the tubules had necrosis. Conclusion: In conclusion, present study showed that Cadmium administration showed a damaging effect on the testis and Virgin coconut oil showed protective role in attuning cadmium induced testicular damage
Stability Indicating Photodiode Array Detector Based Estimation of Dapagliflozin Propanediol Monohydrate in API and Tablet Dosage Form by RP-UPLC
Authors: Patel Ashok B. , Vaghasiya Ekta H. , Dudhatra Amit R. , Vyas Amitkumar J. , Patel Ajay I. , Patel Nilesh K. , Jadav Hina M.
Published: October 2021

Stability indicating RP-UPLC photo diode array detector based method for determination of Dapagliflozin propanediol monohydrate (DPM) in active pharmaceutical ingredient (API) and in tablet dosage form (5mg dapagliflozin) has been developed and validated on Bridge Ethylene Hybride (BEH) C18 column (50mm × 2.1 mm, 1.7µm). Mobile phase composition was water: acetonitrile (60:40 v/v), flow rate 0.5ml/min and detection carried out at 223nm at column temperature 30ºC. Chromatographic separation achieved within 2 min with retention time 0.77 min. Linearity of the method was found over the concentration range of 25-75µg/ml (R2 = 0.9977). The degradation was carried out in five different stress conditions. The developed method was able to resolve peak of API from all generated peaks. Sufficient degradation was achieved in the range of 5.25 to 12.31%. The peak purity is acceptable, Method validation was performed as per ICH guideline Q2(R1).
Application of Hydroxyapatite scaffold from Portunus pelagicus on OPG and RANKL expression after tooth extraction of Cavia cobaya
Authors: Kridanto Kamadjaja Michael Josef , Salim Sherman , Swastyayana Subiakto Birgitta Dwitya
Published: October 2021

Objective: This study was to determine OPG and RANKL expression after hydroxyapatite (HA) scaffold from crab shells (Portunus pelagicus) application in tooth socket of Cavia cobaya. Methods: This study was a post-test only control group design. Twenty four Cavia cobaya was divided into 4 groups. The lower left incisor was extracted and given a combination of HA and gelatin scaffold. Experimental animals were sacrificed on the 7th and 14th day. The amount of OPG and RANKL expression was calculated under a light microscope at 1000x magnification. The statistical analysis was done by One Way ANOVA Test and Tukey HSD. Results: Compared to other groups, the lowest and the highest level of OPG and RANKL were in P14 group. Conclusion: HA scaffold from crab shells (Portunus pelagicus) can increase OPG expression and decrease RANKL expression in the process of regenerating alveolar bone after tooth extraction.