bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinetic oscillation stimulation for the preventive treatment of refractory chronic migraine: a case series
Authors: Liaci Giorgio , Altamura Claudia , Brunelli Nicoletta , Alesina Alessandro , Fofi Luisa , Prudenzano Maria Pia , Vernieri Fabrizio
Published: January 2025

Background: Refractory migraine refers to a subtype of chronic migraine in which individuals experience severe and disabling attacks that do not respond adequately to any pharmacological treatment. In recent years, neuromodulation techniques have emerged as promising therapeutic avenues for refractory migraine management.
Methods: Four patients with refractory chronic migraine were offered a six-week cycle of kinetic oscillation stimulation (KOS), a novel approach of neuromodulation whose target is the sphenopalatine ganglion (SPG). Migraine frequency and medication usage were recorded in a diary; intensity of pain and impact of migraine on patient’s behavior were assessed with validated clinical scales.
Results: All except one patient completed the scheduled sessions. Severity of pain and drug consumption remained stable in most cases. After one month of active stimulation, migraine frequency did not differ substantially from pre-operative monthly average, except in one subject who recorded a reduction of 11 monthly migraine days (MMD). A second treatment cycle was proposed for this patient, considering the excellent clinical outcome.
Conclusions: KOS could be a helpful resource and drug-sparing option for selected patients with refractory migraine. However, more evidence is needed to confirm its efficacy and establish a shared usage protocol.
First observation of mating behavior of the endangered forest musk deer Moschus berezovskii in the wild
Authors: Tran Dung Van , Phan Dai Viet , Vu Thinh Tien , Lau Ky A , Pham Nhung Thi , Pham Hoa Thi , Nguyen Thanh Chi , Pham Thong Van , Tilker Andrew
Published: January 2025

We report the first observation of mating in the endangered forest musk deer (Moschus berezovskii Flerov, 1929) in the wild. The mating took place on 21 January 2023 at a latrine site within karst habitat in Huu Lien Nature Reserve, northern Vietnam. In total, we obtained around ten minutes of camera-trap video footage showing two different mating events of the same individuals. The event highlights the potential importance of latrine sites for interactions among forest musk deer. Our observation provides new insight into the ecology and behavior of this rare and elusive species.
Osteopontin expression in psoriasis versus lichen planus: a comparative immunohistochemical study
Authors: Hassan Ghada F.R. , Ellebidy Esraa S.H. , Elazeem Marwa A.E.A. , Elhawary Esraa E.
Published: January 2025

Background

Psoriasis is a complex immune-mediated chronic inflammatory disorder triggered by various risk factors in genetically susceptible individuals, while lichen planus (LP) is a chronic inflammatory, immune-mediated disease. Osteopontin (OPN) is a phosphorylated acidic glycoprotein produced by several cell types and involved in immune regulation, cellular signaling, inflammation, and vascularization, and plays a role in various physiological and pathological processes. While the literature has many studies regarding OPN expression in psoriasis and oral lichen, no studies were done on cutaneous LP. Furthermore, no comparison between psoriasis and cutaneous LP was made.

Objective

To evaluate OPN expression in psoriasis versus LP as the most common papulosquamous skin disorders in comparison with healthy patients to study its possible role in the pathogenesis of both diseases.

Patients and methods

This comparative study included 40 patients with psoriasis and 40 patients with LP, in addition with 20 healthy individuals as the control group. Skin biopsies were obtained and stained with H and E. Immunohistochemical staining of sections was performed using a human polyclonal anti-OPN IgG antibody to evaluate epidermal and dermal OPN expression in psoriasis and LP sections versus control.

Results

There was a statistically significant decrease in epidermal OPN expression in the patients of both diseases when compared with the control group, but a statistically significant increase in the dermal expression of OPN in both diseases when compared with the control group. In addition, a statistically significant increase in OPN expression was detected in the epidermis of the psoriasis group in comparison with the lichen group. Higher expression of dermal OPN expression is related to severity of the psoriasis area severity index score in psoriasis patients and to the lichen planus severity index in LP.

Conclusion

Due to its significant dermal expression in psoriasis and LP immunohistochemically stained sections, OPN might have an essential role in the pathogenesis of both diseases, and the level of its expression in tissues could indicate the severity of psoriasis and LP.
Recalcitrant ‘knuckle pads’: a revisited case
Authors: Attia Enas
Published: January 2025

Knuckle pads are under reported benign well-defined thickened skin plaques usually overlying the extensor aspect of the small joints of the hands. Primary knuckle pads are a fibromatous disease that may be seen in several inherited fibromatosis and keratoderma syndromes. Secondary knuckle pads are distinctly different from primary knuckle pads, acquired by repetitive trauma, and dermoscopy may aid in diagnosis. We hereby report a case of a female patient with recalcitrant knuckle pads for 8 years, that were confused with psoriasis or erythrokeratoderma. However, after repeated consultations, they were found to be due to body-focused repetitive behaviour of recurrent skin biting, denoting dermatodaxia. After the condition was explained, the patient consciously refrained from biting her knuckles with improvement within a few weeks.
The relationship between Helicobacter pylori and pityriasis versicolor
Authors: El Samahy May H. , Abdelrahman Raafat Z. , Ibrahim Hossam O. , Mostafa Azza E.
Published: January 2025

Background

Although the immune dysregulation caused by Helicobacter pylori has been linked to the pathogenesis of many dermatological diseases, the link between H. pylori infection and pityriasis versicolor (PVC) has not been largely verified.

Objective

To study the probable association between active H. pylori infection and PVC prevalence and clinical parameters.

Patients and methods

The present case control study included 65 male patients with PVC (group A) and 65 dermatologically free patients (group B). Active H. pylori infection was detected in both groups using H. pylori stool antigen test (SAT). In group A, patients who tested SAT positive were subjected to measurement of anti-H. pylori immunoglobulin (Ig)G and IgA and interleukin (IL)-10 serum levels.

Results

The frequency of H. pylori was equal (61.5%) in both study groups. The various clinical parameters of PVC did not significantly differ between SAT-positive and SAT-negative patients. In group A, H. pylori-infected patients had elevated IgG and IgA serum titer, while IL-10 level was in most cases (65%) low. No significant relation was detected between the H. pylori serological markers and the PVC clinical parameters.

Conclusion

Active H. pylori infection did not impact the prevalence or clinical features of PVC. Elevated H. pylori IgG and IgA levels did not vary differentially in relation to PVC clinical features. Moreover, serum IL-10 level in active H. pylori-infected patients with PVC was not elevated. Accordingly, its role as a systemic immunosuppressive cytokine predisposing for PVC was unverified in this study.
Patient-derived VIDA and dermoscopy versus sequential planimetry for assessing activity in vitiligo patients receiving narrowband ultraviolet B: a comparative longitudinal study
Authors: El Eriny Ali F. , Elmorsy Eman H. , Farid Carmen I. , Elrashidy Maha E.
Published: January 2025

Background

Judging the stability/activity of vitiligo is of therapeutic and prognostic significance. Clinical and biochemical activity indicators are available, but none is currently universally accepted.

Objective

To compare the accuracy of patient-derived vitiligo disease activity score (VIDA) and dermoscopy, versus sequential planimetry in determining vitiligo stability/activity.

Patients and methods

A total of 120 nonsegmental otherwise healthy vitiligo patients were included, who reported disease stability for the last 6 months. Global assessment and photography were followed by choosing a stable non-repigmenting lesion for longitudinal evaluation of planimetric changes, and dermoscopy. Patients received the standard protocol of narrow band ultraviolet B for 3 months, and patient recall for global and lesional progression was recorded. Accuracy of patient-derived VIDA and dermoscopic signs, versus planimetric changes as the reference were compared for judging vitiligo stability/activity.

Results

Patient-derived VIDA showed 58.33% accuracy in determining disease stability while Dermoscopy showed 97.50% overall accuracy. The absence of a pigment network and the absence of signs of activity (collective absence of ill-defined border, satellite lesions, and microkoebnerization) showed 100% accuracy in establishing disease stability. On the other hand, the presence of any microkoebnerization, starburst sign, or satellite/tapioca sago sign was 100% indicative of activity. Border definition gave a 91.67% overall accuracy for judging stability, while Perifollicular pigmentation showed an accuracy of 49.17%.

Conclusion

Patient-derived VIDA is generally unreliable, whereas longitudinal follow-up for planimetric changes, and dermoscopic assessment are of better reliability. The absence of pigment network, and collective absence of ill-defined border, microkoebnerization, and satellite lesions are 100% accurate in predicting stable vitiligo.
Analysis of restoration in atrophic scar by intradermal autologous dermal tissue: a pilot study
Authors: Singh Sudhir , Singh Adarsh L. , Singh Deepika
Published: January 2025

Background

Treating depressed atrophic scars, which can result from various causes like post-trauma, acne vulgaris, and varicella, can be challenging. Still, there are several therapeutic modalities available that can help improve their appearance. Developing a method that is easy, safe, and effective in treating depressed scars is a significant goal in dermatology and aesthetics.

Objective

To assess the efficacy of autologous dermal tissue transplantation in correcting atrophic scars due to trauma, acne vulgaris, varicella infection, and other inflammatory diseases and to evaluate any side effects associated with the procedure.

Patients and methods

Eleven patients with depressed atrophic scars willing to undergo the procedure were selected. Dermal tissue harvested after removing the epidermis by dermabrasion, was cut into small pieces, and inserted in the dermis of the recipient site with the help of 18 G needle. 2 experienced dermatologists did assessment of results by using clinical assessment scores.

Results

Out of 11 patients, one patient showed a 25–50% improvement, six patients showed improvement between 51 and 75%, and four patients showed more than 75% improvement. Improvement was good in small linear scars. Milia-like lesion developed in one patient.

Conclusion

Autologous dermal tissue transplantation is effective in depressed scars. The technique is safe, cheap, and can be mastered easily. It is important to continue conducting research and clinical trials to establish the benefits and limitations of autologous dermal tissue transplantation for depressed scars. Additionally, long-term follow-up studies can provide insights into the durability of the treatment results.
Ribociclib-induced vitiligo in a case of metastatic carcinoma of the breast
Authors: Deb Abhira , Dhingra Manthan , Barman Srutee , Raja Thinakaran , Ghosh Abhra
Published: January 2025

Ribociclib, a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, is commonly used to treat hormone receptor-positive (HR+), human epidermal growth factor receptor 2/neu negative (HER2/neu-) breast cancer. While effective in inhibiting cancer cell proliferation, ribociclib has been associated with various dermatologic side effects, including vitiligo. This condition, characterized by the loss of skin pigmentation, occurs due to the destruction of melanocytes. In breast cancer patients undergoing ribociclib therapy, though the exact pathophysiological mechanisms remain under investigation, a possible hypothesis suggests that the development of vitiligo may signal an immune-mediated response, potentially reflecting the drug’s influence on immune modulation. This report presents a case of HR+ and HER2/neu− metastatic breast carcinoma treated with CDK4/6 inhibitor plus endocrine therapy with the development of vitiligo during the treatment.
Tissue and serum levels of substance P in trichodynia of androgenetic alopecia patients
Authors: Gohary Yasser M. , Shaker Olfat G. , Elshimy Lina A. , Osman Shimaa T.
Published: January 2025

Background

Trichodynia or hair pain refers to the painful sensation occurring in the hair and or scalp in the setting of hair shedding. It has been reported mainly in association with telogen effluvium and androgenetic alopecia (AGA). Recently, trichodynia cases have been growing in numbers. Several theories have been proposed to explain the pathogenesis of trichodynia, suggesting a major role for substance P (SP) accompanied by perifollicular inflammation.

Objective

To assess tissue and serum levels of SP in trichodynia occurring in AGA patients.

Patients and methods

This is a case–control study that included 35 patients of trichodynia in AGA as well as 35 age-matched and sex-matched healthy participants included as controls. The diagnosis was made by clinical, trichoscopic examination, and scalp biopsy. Tissue and serum levels of SP were measured using the enzyme-linked immunoassay technique.

Results

The mean tissue levels of SP were significantly higher in patients (448.11±241.24 pg/g), than in controls (75.78±11.81 pg/g) (P<0.0001). The mean serum levels of SP were significantly higher in patients (325.09±218.43 pg/ml), than in controls (171.06±42.19 pg/ml) (P=0.0002). The mean levels of SP in the tissue of patients were significantly higher among those with positive tenderness by examination (322.62±64.11123) compared to those with no tenderness (553.78±284.12157) (P=0.003). The mean levels of SP in the tissue of AGA patients were significantly higher in the group who reported a diffuse distribution of trichodynia (553.78±284.12) than in patients with localized trichodynia (322.62±64.11) (P=0.028).

Conclusion

An increase of SP levels in tissue and serum of trichodynia accompanying AGA patients compared to healthy controls could have a role in trichodynia.
Masquerading details behind a murmur and chest pain
Authors: Orozco Alejandro Narvaez , Navajas Alberto Navarro , Roldan Alejandra Ramirez , Ocampo Camilo Lopez , Sanchez Juan Manuel Senior
Published: January 2025

Masquerading bundle branch block (MBBB) is a rare presentation of bifascicular blocks. It is the result of a right bundle branch block associated with an advanced left anterior fascicular block due to extensive damage to the conduction system. We present the case of a 75-year-old male with late onset presentation anterior wall myocardial infarction (MI) with ongoing ischemia (which evolved into a ventricular septal defect [VSD]). Electrocardiographically, the MBBB is characterized by a prominent R in V1, left axis deviation and absence of small S waves in I and aVL. Its presence confers a poor prognosis and high risk of progressing to advanced atrioventricular block (AAVB). A mortality rate between 18% and 38.9% has been found and 41.4%–59% of the patients develop AAVB requiring pacemaker implantation. To our knowledge, this is the first reported MBBB case in the setting of an MI complicated with VSD, demonstrating its association with the presence of critical anteroseptal ischemia. The patient rejected any kind of intervention, palliative care was offered, and he died 2 months later.
Prilog poznavanju rasprostranjenosti jadranske kozonoške (Himantoglossum adriaticum) na području slavonskog gorja
Authors: Kovačević Marija , Doboš Marko , Samarđić Ivica , Galić Iva , Andrić Vesna , Mikić Karlo
Published: January 2025

The nearly threatened species Adriatic lizard orchid (Himantoglossum adriaticum H. Baumann) was previously known only from a few sites in the Slavonian highlands. This study was conducted to gain a better insight into the current distribution of the species and the status of its populations. Field surveys were mainly carried out from May to July 2020-2024 in known localities and other habitats suitable for the species. Large populations have been discovered at 15 new sites throughout the Slavonian highlands.The plant primarily grows in the areas of Požeška Gora and Psunj in habitats such as grasslands and shrublands. Favorable areas have been significantly reduced due to the abandonment of traditional land management practices and natural succession, while some areas are under strong pressure from invasive species. Even though the populations of H. adriaticum in the Slavonian highlands thriving due to favorable conditions in recent years, it is necessary to implement a continuous monitoring program and collect more extensive data to enable effective management of the areas and the preservation of the species.
Aleja lipa „Zlinje“ u mjestu Blato na otoku Korčuli
Authors: Košćak Miošić-Stošić Vesna , Kremer Dario
Published: January 2025

S ciljem predstavljanja široj javnosti razmjerno slabo poznate aleje lipa „Zlinje“ u mjestu Blato na otoku Korčuli, u ovom radu donosimo pregled njenog sadašnjeg stanja te preporuke za sanaciju i revitalizaciju. Inventarizacija i valorizacija drvoreda lipa „Zlinje“ obavljena je u veljači 2024. godine, pri čemu je evidentirano 232 stabla (117 u sjevernom i 115 u južnom drvoredu). Pri identifikaciji utvrđeno je da stara stabla pripadaju vrsti Tilia platyphyllos Scop., a mlada stabla vrsti T. cordata Mill. S obzirom na dobnu strukturu, u aleji je evidentirano 112 starih stabala (prsnog promjera većeg od 25 cm), 27 srednjedobnih (promjera od 10 do 25 cm) i 93 mlada stabla (promjera do 10 cm). Utvrđeno je i da je 40 stabala vrlo lošeg zdravstvenog stanja te da je njih 39 potrebno odmah ukloniti i zamijeniti mladim stablima, dok još 43 stabla treba staviti pod nadzor i s vremenom zamijeniti. Kao glavni uzrok lošem zdravstvenom stanju ovako velikog broja stabala evidentiran je intenzivni dvosmjeran promet, koji je doveo do značajnih mehaničkih oštećenja većine stabala. Bez obzira na trenutno nepovoljno okruženje, aleji bi trebalo osigurati adekvatnu pažnju i kao krajobraznoj vrijednosti i nositelju identiteta naselja Blato, primjereno je urediti, održavati i zaštititi.
Nove vrste i nomenklaturne preinake u popisu flore Hrvatske – 8
Authors: Bogdanović Sandro
Published: January 2025

Do sada je u Glasniku Hrvatskog botaničkog društva objavljeno sedam priloga koji dopunjuju nacionalni popis flore Hrvatske i bazu podataka Flora Croatica – FCD s novoopisanim i novootkrivenim biljnim svojtama. Osim toga provode se i nomenklaturne preinake već postojećih svojti. Kako bi se taj niz i dalje nastavio, ovaj prilog je osmi u nizu te je u bazu FCD dodano deset novih svojti (Allium dinaricum Bogdanović, Anačkov, Ćato, Borovečki-Voska, Salmeri et Brullo, Carex distachya Desf. subsp. phyllostachioidea (Ö.Nilsson) Jac.Koopman, Więcław, Bogdanović et T. Denchev, Cenchrus longisetus M.C.Johnst., Cenchrus spinifex Cav., Cochlearia danica L., Lepidium oblongum Small, Micromeria silicii Bogdanović, Ljubičić, L. Sáez et Brullo, Prangos trifida (Mill.) Herrnst. et Heyn, Sporobolus indicus (L.) R.Br. i Stachys ocymastrum (L.) Briq.) koje su zabilježene po prvi puta za Hrvatsku. Osim toga, izvršena je jedna nomenklaturna preinaka koja se odnosi na vrstu Allium tenuiflorum Ten., a s popisa su uklonjene tri svojte (A. paniculatum L. subsp. fuscum Waldst. et Kit., A. paniculatum L. subsp. villosulum (Halácsy) Stearn. i A. paniculatum L. subsp. paniculatum).
Prevalence of Use of Sports Trainer Services in Japanese High Schools: A Nationwide Survey
Authors: Shibata Yosuke , Kurita Yasunari , Morishita Kaho , Ojima Toshiyuki
Published: January 2025

Objective: Sports trainers contribute to the safety of adolescent athletes. The status of sports trainer services (STS) that use a trainer-certified system and trainer perceptions differ among countries, and reports from different countries are needed to promote the global use of STS. This study aimed to determine the prevalence of STS and the reasons for its use in Japanese high schools. Method: A cross-sectional study was conducted in 2022. Participants were all club activity coaches from all high schools (around 70,000 coaches) in Japan. The primary outcome was the prevalence of STS use. We obtained information on the payment status when STS was used and the reasons they were not. Results: Of the 6045 coaches included, 10.5% used STS. Volunteer trainers comprised 29.9%, and if they were paid a fee, it needed to be more for a living. The most common reason for not using STS was "no suitable person" (70.8%). Novelty: This was the first large-scale survey of the prevalence of STS use in Japanese high schools. The prevalence of STS use in Japanese high schools was low.
Integrative Entrepreneurship Learning Design: A Study on Islamic Higher Education Institutions in Indonesia
Authors: Yudiana Fetria Eka , Famularsih Sari , Rosyidha Alfin , Muflikah Binti , Raharja Ahmad Ulliyadhi Satria
Published: January 2025

Objective: This research aims to explore entrepreneurship courses' challenges and competency needs at Islamic Higher Education Institutions (IHEI) and develop a compatible learning design for these courses. Method: Using a qualitative approach, data was collected through interviews with entrepreneurship lecturers to identify challenges and department heads to understand supporting policies and curriculum development. Additionally, Semester Learning Plans (RPS) content analysis was conducted to examine course content, competencies, and teaching methods. Results:  The findings revealed inconsistencies in the entrepreneurship course designs across IHEI. Most courses focus on providing entrepreneurial insights and shifting students' mindsets, with limited practical experiences like essential product sales. Non-classroom entrepreneurship activities vary significantly depending on the lecturers' initiative and departmental coordination. Some departments did not prioritize these activities due to unclear guidance. Novelty: The novelty of this research lies in its proposed integrative learning design, which emphasizes knowledge internalization, skill-building, and attitude formation. The design includes four stages: mindset-building, business experience, start-up business, and business development, offering a structured approach to enhance entrepreneurial competencies in IHEI.
The Implementation of Ethnomathematics-Based Student Worksheet “Surya Majapahit” on the Circle Elements Material to Build Creative Thinking of Elementary Students
Authors: Putri Annisa Rizqi Hendrada , Wiryanto Wiryanto , Ekawati Rooselyna , Srinivasarao U
Published: January 2025

Objective: The application of an ethnomathematics-based student worksheet can be associated with Surya Majapahit's cultural heritage in the material of the elements of a circle. The purpose of this study is to describe the application of Surya Majapahit ethnomathematics-based worksheet as a mathematics learning resource, in addition to knowing the perceptions of teachers and students on the results of the application of Surya Majapahit ethnomathematics-based student worksheet carried out, as well as knowing the effect of applying Surya Majapahit ethnomathematics-based student worksheet in building students' creative thinking skills through the evaluation stage Method: This research uses descriptive qualitative research. This study's research subjects were 6th-grade students of  Lengkong II Public School, Mojokerto Regency. Results:  The results of data analysis through material validation in this study show that geometry concepts and values in Surya Majapahit ethnomathematics are seen through values and patterns in each period of government and culture that entered the archipelago. Student learning outcomes show "complete" above the criteria for achieving learning objectives. The results showed an average summative evaluation of 90 and a formative of 92.8, so students can optimize creative thinking skills on local wisdom content with geometry material elements. Novelty: The research innovatively incorporates ethnomathematics, precisely the "Surya Majapahit" Circle elements, into elementary school mathematics learning. This cultural integration can enhance students' engagement and understanding of mathematical concepts. The study seeks to foster a more imaginative and innovative approach to creative problem-solving using ethnomathematics and engaging activities.
Innovation in Building Digital Literacy: Stakeholder Challenges in Growing Suburban Communities
Authors: Harris Taufiq , Faizin A. , Thohirin Ahmad , Romdhoni Ali
Published: January 2025

Objective: This study examines (a) the role of stakeholders in realizing innovation in building digital literacy programs in Gresik Regency, (b) stakeholder efforts in fostering digital literacy awareness, and (c) stakeholder challenges to realizing innovation in building digital literacy programs for suburban communities. Method: The research uses a qualitative approach with grounded theoretical research. The research was conducted in five villages in Gresik Regency, and the research subjects amounted to 40 informants. Data collection uses in-depth interviews, participant observations, and document studies. The analysis of lepangan data uses two methods: (a) an interactive data analysis model and (b) an analysis of the coding process and conclusion. Results: 1) The role of stakeholders in realizing innovation in building digital literacy programs in Gresik Regency starts from village elements and community leaders to become initiators and active participants to villagers in carrying out digital literacy program implementation activities; 2) Stakeholder participation is quite diverse, which is influenced by care, funds, and responsible persons, while the implementation of E-commerce platforms in the local community is very effective and the competition is open; 3) Facing several challenges, especially in terms of digital literacy, limited facilities and concern of the local community. Novelty:  This research combines strategies to generate innovations in various aspects of digital literacy awareness. The critical role of an effective leader is to promote and implement digital education, as well as stakeholders to strengthen literacy education in the current digital era.
The Transformational Leadership of School Principals in Improving the Quality of Vocational High School Graduates in South Aceh
Authors: Ansar  , N. Usman  , Niswanto
Published: January 2025

The transformational leadership of vocational high school (SMK) principals must play a role in improving the quality of education so that students are ready to compete in the current job market and industrial world. This research aims to: 1) Identify transformational leadership programs; 2) Examine the implementation of transformational leadership through the realization of vision and mission; 3) Understand the principal’s ability to provide encouragement and motivation; 4) Explore the principal’s creative and inspiring ideas in efforts to improve the quality of graduates. The research method used is qualitative. The data sources consist of school principals, teachers, educators, and educational staff. Data collection techniques include interviews, observations, and documentation. Data analysis is conducted through data reduction, data presentation, and drawing conclusions. The research results show that: 1) The transformational leadership programs of the school principals include: Idealized influence, where the principal involves all elements in decision-making. Inspirational motivation, where the principal serves as a role model for the school community. Intellectual stimulation, where the principal acts as the main driver in every school development change. Individualized consideration, where the principal pays attention to individual staff members. 2) The implementation of transformational leadership by the school principals is evident in their vision and mission, based on data on the number of graduates accepted in the workforce and industry, as well as those who work independently in their respective fields of expertise. 3) The principal’s ability is demonstrated through the encouragement and motivation provided to teachers and staff through various methods, including training or rewards. 4) The principal’s ideas and efforts to improve quality include adding adequate infrastructure, incorporating teaching factories into learning, providing additional training for students, establishing collaborations with national-scale companies, forming alumni communities, and offering student industrial work practice.
The Impact of Principal-Led Academic Supervision on Teacher Performance in Indonesian Public Schools
Authors: Sunaryadi  , Murniati  , Niswanto
Published: January 2025

This research investigates the role of academic supervision by school principals in improving teacher performance at public high schools in South Aceh Regency. The study focuses on understanding how academic supervision influences various aspects of teacher performance, including lesson planning, classroom management, and instructional effectiveness. A qualitative research design was employed, with data collected through interviews, observations, and document analysis across three schools: SMAN 1 Kluet Selatan, SMAN Unggul Darussaadah, and SMAN 1 Meukek The results demonstrate that academic supervision has a significant positive impact on teacher performance. Schools that conducted frequent supervision sessions and provided professional development workshops observed notable improvements in teacher performance, with average performance ratings increasing by 15% after supervision. The findings suggest that academic supervision, when implemented consistently and supported by workshops, can enhance teacher competencies and improve overall instructional quality. The study also identifies challenges such as resource limitations and logistical constraints that affect the consistency and quality of supervision. This research highlights the importance of integrating academic supervision into school improvement strategies to enhance teaching quality and educational outcomes. Recommendations include increasing the frequency of supervision, offering more professional development opportunities, and addressing challenges related to resources and time constraints. The findings contribute to the growing body of literature on the importance of academic supervision in teacher professional development.
Sonographic findings of recurrent disease at the thyroid bed in differentiated thyroid cancer
Authors: On-Ekkasit Pinyaporn , Subhadhirasakul Sorasich , Busaman Jalat , Pakdeejit Songklod
Published: January 2025

Background: Neck ultrasonography (US) is an important tool for evaluating the response to therapy of differentiated thyroid cancer (DTC) and surveillance of a possible disease recurrence.
Objective: To evaluate sonographic findings associated with recurrent disease at the thyroid bed in patients with DTC.
Materials and methods: This was a retrospective cohort study. We reviewed the data of 26 patients with DTC who underwent thyroidectomy and had thyroid bed lesions detected by neck US between January 2016 and December 2023. Sonographic findings of recurrent and non-recurrent lesions were compared.
Results: A total of 26 thyroid bed lesions in 26 patients were identified, including 17 recurrent and nine non-recurrent lesions. The median size was 1.0 centimeters. Sonographic findings of recurrent versus non-recurrent lesions were hypoechoic in 58.8% versus 55.6%, wider-than-tall in 64.7% versus 100%, smooth margins in 82.4% versus 66.7%, and no calcification in 70.6% versus 88.9%. There was no significant difference in sonographic findings between recurrent and non-recurrent lesions. All 13 patients who had recurrent lesions with available laboratory results had elevated serum Tg and/or TgAb levels.
Conclusion: The sonographic findings alone could not distinguish the recurrent from non-recurrent lesions at the thyroid bed in patients with DTC. Clinical and laboratory results should be correlated to determine the need for further investigations.
An uncommon case of blunt traumatic rupture gallbladder: A diagnostic challenge
Authors: PHUKAN HIMRAJ , LYNSER DONBOKLANG , Lyngwa Gareth Yobel , Daniala Chhunthang , Khongwar Donkupar
Published: January 2025

Gall bladder injury secondary to blunt abdominal injuries are extremely rare and is reported in less than 2% of such cases. Clinical diagnosis is usually difficult due to absence of specific clinical symptoms. We present a case of 31-year-old man with a history of drunk driving leading to road traffic accident coming to our emergency department with mild pain in the periumbilical region. A proper diagnosis was made by ultrasound and computed tomography (CT). CT also revealed injury to the adjacent hepatic segment. The patient was successfully treated with laparotomy and cholecystectomy. Here we discuss the conditions which may predispose to a gall bladder injury and the need for early radiological diagnosis before the signs of biliary peritonitis sets in. Timely intervention carries a good prognosis
"Kierkegaard ist ein Jude!": Jüdische Kierkegaard-Lektüren in Literatur und Philosophie
Authors: Nowotny Joanna
Published: January 2025

Joanna Nowotny untersucht in ihrer groß angelegten Studie, welche Spuren Kierkegaards Schreiben und Denken im theoretischen Diskurs und der literarischen Kultur der jüdischen Moderne hinterlassen haben.

»Kierkegaard ist ein Jude!«, notiert Gershom Scholem im Jahr 1915 begeistert in seinem Tagebuch. »[N]irgends« sei der »Kern des jüdischen Weltgefühls […] so klar, so erlebt formuliert« wie bei Kierkegaard, schreibt Max Brod einige Jahre später in »Heidentum - Christentum - Judentum« (1921). Derartige Deutungen sind bemerkenswert. Sie werfen die Frage auf, inwiefern Kierkegaards Werk, das nach 1900 im deutschsprachigen Europa ohnehin Hochkonjunktur hatte, insbesondere für eine jüdische Rezeption Interpretations- und Aneignungsmöglichkeiten bereithielt. Wie wird Kierkegaards Denken in diesem Kontext theologisch, politisch und literarisch fruchtbar gemacht, von Dichtern und Denkern wie Martin Buber, Franz Rosenzweig und Franz Kafka? Welche Aspekte seines Werks spielen eine besondere Rolle? Welcher Gestus liegt den verschiedenen Kierkegaard-Aneignungen zugrunde und welche Funktionen erfüllen sie etwa im Rahmen jüdischer Identitätsdiskurse? Diesen Fragen widmet sich Joanna Nowotny in ihrer Studie und zeigt, welche Spuren Kierkegaards Schreiben und Denken bei Autoren wie Martin Buber, Gershom Scholem, Franz Werfel oder Franz Kafka hinterlassen haben.
Ensamblajes revolucionarios en Manuel de Landa: de una ontología a una política posthumana
Authors: Ayala-Colqui Jesús , Castillo Villapudua Karla
Published: January 2025

El artículo intenta explicar los elementos ontológicos, tanto posiblemente revolucionarios como posthumanos, del programa filosófico de Manuel De Landa. Inicialmente revisa la influencia de la ontología de la diferencia en Gilles Deleuze, enfatizando las nociones de multiplicidad y virtualidad. Enseguida, analiza la teoría de los ensamblajes de De Landa como una alternativa a las teorías de las totalidades orgánicas. Después, interroga sobre el sentido propiamente posthumano de los ensamblajes revolucionarios. Finalmente ofrece una conclusión en la cual establece las afinidades posthumanas de la filosofía de la diferencia de Deleuze con la teoría de los ensamblajes de De Landa.
Eyectarse hacia el cosmos: aproximaciones postfenomenológicas, astrobiológicas y astropolíticas al transhumanismo en la era del colapso planetario
Authors: Andrade Ricardo
Published: January 2025

El presente artículo tiene como objetivo esbozar una aproximación al transhumanismo desde la postfenomenología, la astrobiología y la astropolítica. Ahondar en el primer ámbito permite destacar la importancia que tiene este movimiento tecnológico y filosófico para comprender cómo la unión entre los artefactos técnicos y los sujetos puede crear las condiciones idóneas para una ontogenia posthumana, es decir, una superación de la especie humana a través de la tecnología. Las consecuencias de esta posibilidad abarcan múltiples áreas, de las cuáles la astropolítica y la astrobiología han sido escasamente estudiadas en lengua española. Incorporar estos dos ámbitos ofrece un panorama especulativo no menor para visualizar lo que serían las disputas políticas, económicas y existenciales de una futura civilización posthumana en hipotéticos asentamientos espaciales. Estas disputas en conjunto con el proyecto de colonización del cosmos tienen como fondo el colapso de la Tierra, lo cual despierta una serie de interrogantes sobre si es posible detener en otros lugares las mismas dinámicas que han originado la destrucción de este planeta. Esto implica, de manera ineludible, resaltar las tensiones y la lucha por los imaginarios tecnológicos. Para analizar todos estos elementos, el artículo está organizado en tres partes. La primera es una introducción teórica a la postfenomenología. A partir de esto, la segunda ahonda en el transhumanismo, en especial en la figura del cyborg para, finalmente, analizar en la tercera sección las implicaciones astropolíticas y astrobiológicas de este ente posthumano.
La planitud material del socio-constructivismo. Una crítica realista y neo-existencial de los nuevos materialismos
Authors: Binetti Maria
Published: January 2025

Los nuevos materialismos se presentan como una posible vía de exploración en el marco del giro ontológico que caracteriza al presente siglo y lo separa del paradigma lingüisticista dominante durante las últimas décadas del siglo pasado. Contra la hegemonía del discurso, el análisis del lenguaje y los estudios culturales, los nuevos materialismos postulan la irreductibilidad de un sustrato material autoactivo, pluripotencial y morfogenético, multiplicado por enredos de actantes y ensamblajes. La materia es una misma y sola vida, plana y unívoca en sus heterogéneas actualizaciones. Baruch Spinoza, Gilles Deleuze y Félix Guattari se encuentran entre las principales fuentes de inspiración de ese uno-todo animado, cuya materia siente, conversa, sufre, desea y anhela, recuerda. Sin embargo, a pesar de su buena voluntad metafísica, entendemos que estos neo-materialismos insisten en un fisicalismo óntico finalmente resuelto en construcciones imaginarias. Tal como afirma Deleuze, la inmanencia material es un constructivismo que encuentra en el imaginario individual las proyecciones esquematizantes de indecidibles flujos energéticos. Consecuencia de ese constructivismo es la deriva post/transhumanista de estos materialismos, confiados en el progreso moral y política que la tecnociencia haría posible. El presente trabajo intentará mostrar la matriz constructivista de los nuevos materialismos, funcionales a la desregulación del mercado y la libre producción post/transhumana. Como alternativa, propondré un realismo neo-existencial centrado en el concepto de Geist en tanto que dimensión natural de la vida humana.
Preparation and Characterization of Propolis (Trigona sp.) Extract-Loaded Chitosan Tripolyphosphate Nanoparticles
Authors: Sari Puspita , Watiningsih Lusi Karlina , Fachri Boy Arief , Fauzi Mukhammad , Sutarsi Suratsi , Rumaisha-Zuhriansyah Rayya
Published: January 2025

Propolis contains natural polyphenolic compounds with various biological activities, however, its application is limited due to low water solubility, instability in an aqueous medium, and low absorption rate in the body. The solution to overcome these drawbacks is to create nanoparticles of propolis extract. In this study, we encapsulated propolis extract in nanoparticles (propolis extract-loaded nanoparticles, PE-NP) using low/medium molecular weights of chitosan (LMW/MMW) and cross-linker sodium tripolyphosphate (TPP) by ionic/ionotropic gelation method as wall materials. We examined the physical characteristics (pH, turbidity, encapsulation efficiency, particle size, polydispersity index, zeta potential) and antioxidative properties of PE-NP prepared with the different molecular weights of chitosan, various concentrations of chitosan, and different volumes of propolis extracts. The resulting PE-NP revealed low encapsulation efficiency (23.937 - 41.192%) and pH in the range of 3.9 - 4.8. PE-NP also presented antioxidant capacity that was contributed by polyphenolic compounds in propolis extract. The suspension of PE-NP had a particle size of 350.000 - 488.280 nm with PDI values higher than 0.3 (heterogeneous dispersion), and positive zeta potential (39.340 - 48.200 mV), resulting in stable nanoparticles. The PE-NP produced can be used as functional ingredients in the food industry due to their antioxidative property.
Effect of Steam Treatment on The Shelf Life of Tomato (Solanum Lycopersicum L.) Fruits
Authors: Balogun Olalekan Topsy , Abiola Aborisade Titilope , Modupe Akomolafe Olatunji
Published: January 2025

The effect of heating harvested fruits before storage varies depending on factors such as the fruit cultivar, heating method, and storage conditions. In this research, tomato fruits at different maturity stages were treated with steam and then stored at 28°C. Mature-green stage fruits heated at 55°C for 10 and 30 minutes showed no signs of rot for 24 days. Breaker-stage fruits heated at 55°C for 10 and 20 minutes, as well as at 60°C for 10 minutes, remained disease-free during storage. Heating at 55°C for 30 minutes enhanced the colour development of mature-green fruits, and the same effect was observed for breaker-stage fruits heated at 55°C and 60°C for 20 minutes. However, steam treatment did not effectively protect red-ripe fruits, as they decayed faster than the control group. Significant heat injury was observed only in breaker stage fruits heated for 20 and 30 minutes at 55°C, and 10 and 30 minutes at 60°C. The fungi causing decay isolated from diseased fruits were Fusarium oxysporum, Colletotrichum gloeosporioides, Rhizopus stolonifer, Geotrichum candidum, and Aspergillus niger.
Comparative Evaluation of the Effects of Conservation Agriculture Integrated with Various Land Management Practices on Vertisol Productivity in Highlands of Ethiopia
Authors: Mitiku Getacher Kassa , Woldemariam Ayele Desalegn , Abebe Tilahun Getachew , Atilaw Kebede Bekele , Yilma Temesgen , Getaneh Lisanu
Published: January 2025

Vertisols are dark-colored clays that develop cracks when it expands and contracts with changes in moisture content. Tillage techniques and frequency have an impact on crop harvesting, drainage, soil erosion, moisture conservation, and weeding in Ethiopia's highlands. Five tillage methods, namely, broad bed and furrows (BBF), permanently raised bed with no-tillage (PRB+NT), permanently raised bed with no-tillage, and 30% stubble retention (PRB+NT+M), flatbed with no-tillage (Flat+NT), and flatbed with no-tillage and 30% stubble retention (Flat+NT+M), were evaluated for their effects on the productivity of vertisol. This study was conducted in Moretna Jiru wereda, Enewari, for seven years (2015 to 2022) in the central highlands of Ethiopia. In this study, soil indicators such as moisture content, bulk density, organic carbon, pH, available phosphorus, extractable potassium, electrical conductivity, and total nitrogen, as well as productivity indicators such as plant height, grain yield, and straw yield, were measured. The results indicated that Flat+NT+M and Flat+NT significantly increased wheat grain yield by 13.4% and 11.2%, respectively compared with BBF, for the experimental years 2015/16 and 2017/18. In the experimental years 2019/20 and 2021/22, the wheat yield was greater under BBF than conservation agriculture practices. Compared with conservation agriculture practices, BBF resulted in the highest grain yield of faba bean. The soil property data imply that PRB+NT+M, Flat+NT, and Flat+NT+M improved the total nitrogen, soil pH, organic carbon, moisture holding capacity, and extractable potassium. Economically, Flat+NT was the most profitable practice, with an 1147.6% marginal rate of return (MRR). Based on the results, Flat+NT and Flat+NT+M are beneficial for wheat production during dry years, while BBF is beneficial for fababean production.
Agriculture and Culture Based Agrotourism: for the Development of Sibetan Village, Bali
Authors: Sukanteri Ni Putu , Tamba I Made , Pratiwi Ni Luh Putu Kirana
Published: January 2025

Global competition between tourism destinations is increasing, more and more countries are valuing tourism resources. The aim of the research is to analyze the prospects and challenges facing the development of natural resource-based agrotourism in tropical villages in Bali, analyze the physical assets owned by Sibetan village as an agrotourism destination (agrotourism in East Bali) Analyze agrotourism development strategies in Sibetan Village. This research was conducted in Sibetan Village, Banyakdem District, Karangasem Regency, Bali Province, Indonesia.  Research data was obtained from primary data regarding Sibetan village agrotourism, agrotourism activities, characteristics of agrotourism actors and agrotourism visitors at home and abroad. The research results show that the prospects and challenges for developing natural resource-based agrotourism in Bali are local culture that is open to general visitors and provides the experience of participating in cultural attractions in Sibetan Village. Challenges include weak promotion, the distance between agrotourism and the airport for national and foreign tourists and competition between agrotourism.  The physical assets owned by Sibetan Village are local culture which only exists in Sibetan Village, Sibetan Salak only found in Sibetan Village, and outhor recreation.  The strategy for developing agrotourism in Sibetan Village is to develop an aggressive strategy, so as to be able to create alternative agro-based tourism in Sibetan Village with superior Balinese salak products. The novelty of the research is agrotourism opportunities based on local cultural traditions, Sibetan snake fruit agricultural commodities, full participation from the community, government and management, collaborating with international tourism institutions and celebrity  for promotion
Quality Analysis of Natural Processed Coffee Using Different Roasting Levels
Authors: Apriliyani Mulia Dwi Nur , Savitri Dyah Ayu , Suud Hasbi Mubarak , Wulanjari Distiana
Published: January 2025

Coffee is one of the leading plantation commodities in Indonesia. High-quality coffee has a higher price than low-quality coffee. The quality of coffee is determined by the method of selecting planting materials, handling during harvest, and processing. Coffee that is processed naturally, will be dried in the form of fruit/cherry so that coffee will decrease in quality. The quality of coffee beans can be improved if the roasting process is carried out using the right roasting temperature and time. With a variety of treatments in post-harvest processing methods and roasting levels will produce different coffee quality so that appropriate treatment is needed to determine the final result of coffee with the best quality. This study used the Complete Randomized Design (CRD) method with 2 factors, namely differences in coffee types (robusta coffee and arabica coffee) and roasting levels (light roast, medium roast, and dark roast). The research variables observed were seed weight, camba density, water content, and caffeine content. The data obtained will be analyzed using analysis of variance. If there is a significant difference between treatments, then further tests will be carried out using the Duncan Multiple Range Test (DMRT) at the 5% failure level.