bluuebunny/crossref_metadata_2025 huggingface dataset:
A Computation Fluid Dynamics Methodology for the Analysis of the Slipper–Swash Plate Dynamic Interaction in Axial Piston Pumps
Authors: Muzzioli Gabriele , Paltrinieri Fabrizio , Montorsi Luca , Milani Massimo
Published: September 2023

This paper proposes a CFD methodology for the simulation of the slipper’s dynamics of a swash-plate axial piston unit under actual operating conditions. The study considers a typical slipper design, including a vented groove at the swash-plate interface. The dynamic fluid–body interaction (DFBI) model is exploited to find the instantaneous position of the slipper, while the morphing approach is adopted to cope with the corresponding mesh distortion. A modular approach is adopted to ensure high-quality mesh on the entire slipper surface and sliding interfaces provide the fluid dynamic connection between neighboring regions. The external forces acting on the slipper are included by means of user-defined lookup tables with the simulation estimating the lift force induced by fluid compression. Moreover, the force produced by the metal-to-metal contact between the slipper and the swash plate is modeled through a specific tool of the software. The pressure signal over an entire revolution of the pump is taken as an input of the simulation and a variable time step is used to manage the high-pressure gradients occurring in the regions of inner and outer dead points of the piston. The weakly compressible characteristic of the fluid is considered by a specific pressure-dependent density approach, and the two-equation eddy-viscosity k-ω SST (shear stress transport) model is used to assess the turbulent behavior of the flow. Furthermore, the transitional model predicts the onset of transition, thus solving different equations depending on whether the flow enters a laminar or turbulent regime. In conclusion, the proposed methodology investigates the motion of the slipper in response to several external forces acting on the component. The numerical results are discussed in terms of variable clearance height, pressure distribution within the gap, and lift forces acting on the slipper under specific pump operations.
Understanding the Significance of Cultural Heritage in Society from Preschool: An Educational Practice with Student Teachers
Authors: Pérez-Guilarte Yamilé , Gusman Inês , Lois González Rubén Camilo
Published: September 2023

To understand the significance that cultural heritage has today and, above all, the role of citizens in decision-making for its valorisation, transmission, and management, it is necessary to approach it from a very early age, specifically through childhood education. Hence, this action research study is proposed for 56 infant teachers in initial training at the University of A Coruña (Galicia, Spain). This is a descriptive case study that aims to investigate the perceptions of early childhood education teachers in initial training about cultural heritage (definition: economic, cultural, and educational uses; agents involved in its transmission, management, etc.). In addition, the paper analyses the changes and continuities that occur in student teachers’ perceptions after carrying out a didactic proposal through relevant social problems linked to the Ribeira Sacra cultural landscape. This action research study has allowed students to give more importance to intangible cultural heritage and to gain a better understanding of controversial issues related to cultural heritage, such as the balance between economic and cultural use, as well as citizens’ roles in a decision-making process related to cultural heritage. Despite engaging in didactic activities, a substantial portion of students still retain a conservative outlook on heritage education.
Multivessel Coronary Artery Disease Complicated by Diabetes Mellitus Has a Relatively Small Effect on Endothelial and Lipoprotein Lipases Expression in the Human Atrial Myocardium and Coronary Perivascular Adipose Tissue
Authors: Knapp Małgorzata , Łukaszuk Bartłomiej , Lisowska Anna , Hirnle Tomasz , Górski Jan , Chabowski Adrian , Mikłosz Agnieszka
Published: September 2023

Endothelial (EL) and lipoprotein (LPL) lipases are enzymes involved in lipoproteins metabolism and formation of atherosclerosis, a pathological feature of coronary artery disease (CAD). This paper examines the role of the lipases in the right atrial appendage (RAA) and coronary perivascular adipose tissue (PVAT) of patients with CAD alone or with accompanying diabetes. Additionally, correlation analysis for plasma concentration of the lipases, apolipoproteins (ApoA-ApoJ) and blood lipids (Chol, HDL-C, LDL-C, TAG) was performed. We observed that CAD had little effect on the lipases gene/protein levels in the RAA, while their transcript content was elevated in the PVAT of diabetic CAD patients. Interestingly, the RAA was characterized by higher expression of EL/LPL (EL: +1-fold for mRNA, +5-fold for protein; LPL: +2.8-fold for mRNA, +12-fold for protein) compared to PVAT. Furthermore, ApoA1 plasma concentration was decreased, whereas ApoC1 and ApoH were increased in the patients with CAD and/or diabetes. The concentrations of ApoC3 and ApoD were strongly positively correlated with TAG content in the blood, and the same was true for ApoB with respect to LDL-C and total cholesterol. Although plasma concentrations of EL/LPL were elevated in the patients with diabetes, CAD alone had little effect on blood, myocardial and perivascular fat expression of the lipases.
Tuning Molecular Orientation Responses of Microfluidic Liquid Crystal Dispersions to Colloid and Polymer Flows
Authors: Bezrukov Artem , Galyametdinov Yury
Published: September 2023

An important approach to molecular diagnostics is integrating organized substances that provide complex molecular level responses to introduced chemical and biological agents with conditions that optimize and distinguish such responses. In this respect, liquid crystal dispersions are attractive components of molecular diagnostic tools. This paper analyzes a colloid system, containing a nematic liquid crystal as a dispersed phase, and aqueous surfactant and polymer solutions as the continuous phases. We applied a microfluidic approach for tuning orientation of liquid crystal molecules in picoliter droplets immobilized on microchannel walls. Introduction of surfactant to the aqueous phase was found to proportionally increase the order parameter of liquid crystal molecules in microdroplets. Infusion of polymer solutions into surfactant-mediated microfluidic liquid crystal dispersions increased the order parameter at much lower surfactant concentrations, while further infusion of surfactant solutions randomized the orientation of liquid crystal molecules. These effects were correlated with the adsorption of surfactant molecules on surfaces of microdroplets, stabilizing the effect of a polymer matrix on bound surfactant ions and the formation of insoluble polymer–colloid aggregates, respectively. The revealed molecular behavior of liquid crystal dispersions may contribute to optimized synthesis of responsive liquid crystal dispersions for in-flow molecular diagnostics of polymers and colloids, and the development of functional laboratory-on-chip prototypes.
Dynamic Changes in miRNA Expression during the Generation of Expanded and Activated NK Cells
Authors: Reina-Ortiz Chantal , Mozas Mª Pilar , Ovelleiro David , Gao Fei , Villalba Martín , Anel Alberto
Published: September 2023

Therapies based on allogenic Natural Killer (NK) cells are becoming increasingly relevant, and our laboratory has produced expanded and activated NK (eNK) cells that are highly cytotoxic against several hematological cancers when used alone or in combination with currently approved therapeutic monoclonal antibodies. In order to produce eNK cells, healthy human donor NK cells undergo a 20-day expansion protocol with IL-2, IL-15 and Epstein–Barr virus (EBV)-transformed lymphoblastoid feeder cells. In order to produce an even more potent eNK-based therapy, we must elucidate the changes our protocol produces within healthy NK cells. To understand the post-transcriptional changes responsible for the increased cytolytic abilities of eNK cells, we performed microRNA (miRNA) expression analysis on purified NK cells from day 0 and day 20 of the protocol using quantitative reverse transcription PCR (RT-qPCR). Of the 384 miRNAs profiled, we observed changes in the expression of 64 miRNAs, with especially significant changes in 7 of them. The up-regulated miRNAs of note were miRs-146a, -124, -34a, and -10a, which are key in the regulation of cell survival through the modulation of pro-apoptotic genes such as PUMA. The down-regulation of miRs-199a, -223, and -340 was also detected and is associated with the promotion of NK cell cytotoxicity. We validated our analysis using immunoblot and flow cytometry studies on specific downstream targets of both up- and down-regulated miRNAs such as PUMA and Granzyme B. These results corroborate the functional importance of the described miRNA expression patterns and show the wide variety of changes that occur in eNK cells at day 20.
Whole-Genome Sequencing Identified New Structural Variations in the DMD Gene That Cause Duchenne Muscular Dystrophy in Two Girls
Authors: Pluta Natalie , von Moers Arpad , Pechmann Astrid , Stenzel Werner , Goebel Hans-Hilmar , Atlan David , Wolf Beat , Nanda Indrajit , Zaum Ann-Kathrin , Rost Simone
Published: September 2023

Dystrophinopathies are the most common muscle diseases, especially in men. In women, on the other hand, a manifestation of Duchenne muscular dystrophy is rare due to X-chromosomal inheritance. We present two young girls with severe muscle weakness, muscular dystrophies, and creatine kinase (CK) levels exceeding 10,000 U/L. In the skeletal muscle tissues, dystrophin staining reaction showed mosaicism. The almost entirely skewed X-inactivation in both cases supported the possibility of a dystrophinopathy. Despite standard molecular diagnostics (including multiplex ligation-dependent probe amplification (MLPA) and next generation sequencing (NGS) gene panel sequencing), the genetic cause of the girls’ conditions remained unknown. However, whole-genome sequencing revealed two reciprocal translocations between their X chromosomes and chromosome 5 and chromosome 19, respectively. In both cases, the breakpoints on the X chromosomes were located directly within the DMD gene (in introns 54 and 7, respectively) and were responsible for the patients’ phenotypes. Additional techniques such as Sanger sequencing, conventional karyotyping and fluorescence in situ hybridization (FISH) confirmed the disruption of DMD gene in both patients through translocations. These findings underscore the importance of accurate clinical data combined with histopathological analysis in pinpointing the suspected underlying genetic disorder. Moreover, our study illustrates the viability of whole-genome sequencing as a time-saving and highly effective method for identifying genetic factors responsible for complex genetic constellations in Duchenne muscular dystrophy (DMD).
Spaceflight-Induced Gene Expression Profiles in the Mouse Brain Are Attenuated by Treatment with the Antioxidant BuOE
Authors: Kremsky Isaac , Ali Samir , Stanbouly Seta , Holley Jacob , Justinen Stephen , Pecaut Michael , Crapo James , Mao Xiaowen
Published: September 2023

The demands of deep space pose a health risk to the central nervous system that has long been a concern when sending humans to space. While little is known about how spaceflight affects transcription spatially in the brain, a greater understanding of this process has the potential to aid strategies that mitigate the effects of spaceflight on the brain. Therefore, we performed GeoMx Digital Spatial Profiling of mouse brains subjected to either spaceflight or grounded controls. Four brain regions were selected: Cortex, Frontal Cortex, Corunu Ammonis I, and Dentate Gyrus. Antioxidants have emerged as a potential means of attenuating the effects of spaceflight, so we treated a subset of the mice with a superoxide dismutase mimic, MnTnBuOE-2-PyP 5+ (BuOE). Our analysis revealed hundreds of differentially expressed genes due to spaceflight in each of the four brain regions. Both common and region-specific transcriptomic responses were observed. Metabolic pathways and pathways sensitive to oxidative stress were enriched in the four brain regions due to spaceflight. These findings enhance our understanding of brain regional variation in susceptibility to spaceflight conditions. BuOE reduced the transcriptomic effects of spaceflight at a large number of genes, suggesting that this compound may attenuate oxidative stress-induced brain damage caused by the spaceflight environment.
Investigation of the Bearing Capacity of Transport Constructions Made of Corrugated Metal Structures Reinforced with Transversal Stiffening Ribs
Authors: Kovalchuk Vitalii , Sysyn Mykola , Movahedi Rad Majid , Fischer Szabolcs
Published: September 2023

Methods of increasing the bearing capacity of corrugated metal structures of transport constructions using transversal stiffening ribs in the form of additional corrugation and stiffeners are given. Based on the theory of elasticity, a mathematical model for estimating the stress-strain state of transport constructions made of corrugated metal structures reinforced with stiffening ribs in the form of double corrugation was developed. The method of determining equivalent forces during rolling stock passage is offered. It has been established that double corrugation increases the bearing capacity of corrugated metal structures. Therefore, additional corrugation of corrugated metal structures reduces stresses by up to 20% and deflections by 50%. The obtained results show that the increase in rolling stock speed does not lead to a significant increase in stresses and strains in CMS when the railway track corresponds to the design state.
Long-Term Outcomes at Skeletal Maturity of Combined Pelvic and Femoral Osteotomy for the Treatment of Legg–Calve–Perthes Disease
Authors: Regan Christina M. , Su Alvin W. , Stans Anthony A. , Milbrandt Todd A. , Larson A. Noelle , Shaughnessy William J. , Grigoriou Emmanouil
Published: September 2023

Surgical treatment for Legg–Calve–Perthes disease (LCPD) is recommended for older children with moderate to severe disease. We sought to determine whether double osteotomies lead to improved radiologic outcomes compared to reported non-operative outcomes. Patients older than 6 years of age diagnosed with LCPD lateral pillar B or C who were treated with pelvic and femoral osteotomies were included. Radiologic outcomes and leg-length discrepancies were assessed using the Stulberg classification and were compared with the current literature. Fifteen hips in fourteen patients were treated with double osteotomy for LCPD, and seven had lateral pillar C disease (47%). The mean age at surgery was 8.6 years (range, 7.2–10.4) and the mean age at follow-up was 20.2 years (range, 14.2–35.6). At a mean 11.6-year follow-up (range: 6.3–25.2), double osteotomy resulted in 40% of patients having Stulberg I/II scores, 27% having Stulberg III scores, and 33% having Stulberg IV/V scores. The mean leg-length discrepancy was 1.4 cm in lateral pillar C patients compared to 0.8 cm in lateral pillar B patients. Four patients underwent additional surgeries, including two who required total hip arthroplasty. Double osteotomy as an alternative surgical procedure for the treatment of LCPD did not show improved outcomes when compared to historic non-operative cohorts.
Adjunctive Damage Model to Describe the Interaction of Different Defect Types in Textile Composites on the Strain-Rate-Dependent Material Behaviour
Authors: Protz Richard , Koch Ilja , Gude Maik
Published: September 2023

Textile composites are predestined for crash-loaded lightweight structures due to their adjustable energy absorption capacity, but they can exhibit different types of defects that occur during production (voids) and in operation (fatigue). The influence of such defects, especially the interaction of several defect types on the strain-rate-dependent material behaviour, is still insufficiently researched and can represent a safety risk. Therefore, this paper presents a phenomenological model that can be used to mathematically describe the strain-rate-dependent stress-strain behaviour of nominally defect-free and defect-affected textile composites. An adjunctive damage model in the sense of continuum damage mechanics is introduced, which also considers the interaction of both defect types for the first time. For the model validation, extensive experimental tests on glass fibre non-crimp fabrics reinforced epoxy (GF-NCF/EP) composites are performed. The focus is put on the influence of voids and fatigue-related pre-damage under subsequent tensile loading at strain rates up to 40 s−1. The theoretical studies show a good coincidence with the experimental results. The novel model provides a method for the efficient generation of material maps for numerical highly dynamic crash and impact analyses for defect-free and defective textile composites. As a result, a flexible and practice-oriented model approach is available, which makes a significant contribution to an improved understanding of materials and enables a future defect-tolerant design of textile composites.
Film Properties of Pectin Obtained from Various Fruits’ (Lemon, Pomelo, Pitaya) Peels
Authors: Jiang Haitao , Zhang Wanli , Khan Mohammad Rizwan , Ahmad Naushad , Rhim Jong-Whan , Jiang Weibo , Roy Swarup
Published: September 2023

Food by-products, as sources of high-value compounds, have shown great promise for formulating novel food packaging and edible films for food preservation. This work focused on extracting pectin from lemon, pomelo, and pitaya peels using an ethanol precipitation method. The degree of esterification and the monosaccharide composition of the extracted pectin were determined, and the antioxidant activity of the pectin was assessed. Subsequently, pectin-based films were prepared using the casting method, employing pectin from various sources. These films’ physical and mechanical properties (tensile strength and elongation at break) were assessed, and their microstructure and intermolecular interactions were examined using scanning electron microscopy and Fourier transform infrared spectroscopy analysis. The results of this study demonstrate variations in the degree of esterification among the three pectin samples, with pomelo peel and lemon peel pectins exhibiting higher degrees of methylation compared to pectin from pitaya peel, which had a lower degree of methylation. However, no significant differences were observed regarding the films’ moisture content and water vapor permeability. Notably, the films made from pitaya peel pectin exhibited superior tensile strength and elongation at break to those derived from pomelo peel and lemon peel pectins. The pectin recovered from these fruit peels had great film properties and thus could be utilized for food packaging and edible films.
Influence of Reflective Coating on Temperature Field and Temperature Effect of CRTS III Slab Ballastless Tracks on Bridges
Authors: Song Li , Wu Lei , Cui Chenxing , Yu Zhiwu
Published: September 2023

To minimize the adverse effects of high temperatures on the service performance of track structures, research on the application of reflective coatings on track structures is urgently needed. Based on meteorological data and the characteristics of the multi-layer structure of the ballastless track, refined finite element models (FEMs) for the temperature field and temperature effect analysis of the CRTS III slab ballastless track structure on bridges were established. The temperature deformation characteristics and temperature stress distribution of the CRTS III slab ballastless track under natural environmental conditions were investigated. Similarly, the influence of a reflective coating on the structural temperature field and temperature effect was studied. The results showed that the temperature and vertical temperature gradient of the track slab were significantly reduced after the application of the reflective coating. Meanwhile, the thermal deformation and thermal stresses of the track slab and the self-compacting concrete (SCC) layer were minimized. Under high-temperature conditions in summer, the maximum temperature of the track slab decreased from 47.0 °C to 39.6 °C after the application of the reflective coating, and the maximum vertical temperature gradient of the track slab decreased from 61.5 °C/m to 39.1 °C/m after the application of the reflective coating. Under the maximum positive temperature gradient, the peak displacement of the upper arch in the middle of the slab and the peak displacement of the sinking in the slab corner decreased from 0.814 mm and 1.240 mm to 0.441 mm and 0.511 mm, respectively, and the maximum transverse tensile stresses of the track slab reduced from 2.7 MPa to 1.5 MPa as well. In addition, the reflective coating could also inhibit the failure of the interlayer interface effectively. The results of this study can provide a theoretical basis and reference for the application of reflective coatings on ballastless tracks on bridges.
Effect of Pretreatment on the Nitrogen Doped Activated Carbon Materials Activity towards Oxygen Reduction Reaction
Authors: Dobele Galina , Plavniece Ance , Volperts Aleksandrs , Zhurinsh Aivars , Upskuviene Daina , Balciunaite Aldona , Jasulaitiene Vitalija , Niaura Gediminas , Talaikis Martynas , Tamasauskaite-Tamasiunaite Loreta , Norkus Eugenijus , Kvello Jannicke , Colmenares-Rausseo Luis César
Published: September 2023

Nitrogen-doped activated carbons with controlled micro- and mesoporosity were obtained from wood and wastes via chemical processing using pre-treatment (pyrolysis at 500 °C and hydrothermally carbonization at 250 °C) and evaluated as oxygen reduction catalysts for further application in fuel cells. The elemental and chemical composition, structure and porosity, and types of nitrogen bonds of obtained catalyst materials were studied. The catalytic activity was evaluated in an alkaline medium using the rotating disk electrode method. It was shown that an increase in the volume of mesopores in the porous structure of a carbon catalyst promotes the diffusion of reagents and the reactions proceed more efficiently. The competitiveness of the obtained carbon materials compared to Pt/C for the reaction of catalytic oxygen reduction is shown.
Effect of an Early-Age Exposure on the Degradation Mechanisms of Cement Paste under External Sulfate Attack
Authors: Metalssi Othman Omikrine , Ragoug Rim , Barberon Fabien , Lacaillerie Jean-Baptiste d’Espinose de , Roussel Nicolas , Divet Loïc , Torrenti Jean-Michel
Published: September 2023

Among the most significant causes of concrete degradation is ESA (external sulfate attack). The majority of studies are currently conducted on samples that have been saturated and matured. Concrete structures, however, are exposed to the environment once the formwork has been removed. The purpose of this study is to determine what effects early exposure to external sulfates may have on degradation mechanisms. Microstructure, physical, and chemical behavior are monitored using a variety of experimental techniques, including NMR (27Al and 29Si), ICP, XRD, MIP, and SEM. Based on expansion measurements, mature Portland cement paste, unlike the early-age case, degraded rapidly due to the presence of compressed ettringite and gypsum, highlighted by SEM analysis. During ESA, sulfate ions diffuse through the cement matrix and are bound by chemical agents. Chemical analyses indicate that the chemical mechanism varies with the duration of curing. At an early age, external sulfates and aluminates are the most important reagents. For matured cases, these reagents include external sulfates, calcium derived from CH dissolution, and aluminates derived from the total dissolution of AFm.
The Fatal Defects in Cast Al-Si Alloys Due to Sn Addition
Authors: Xiao Yao , Wang Jicheng , Deng Qianyu , Feng Li , Peng Dianming , Feng Hui , Li Kai , Du Yong
Published: September 2023

Cast defects are common in cast alloys and they are difficult to eliminate without deformation. They strongly degrade the mechanical properties of cast alloys. The addition of some elements can affect the number of cast defects. In this work, the deleterious effect of Sn addition on the mechanical properties of Al-Si alloys has been investigated via 3D-computed tomography, SEM and TEM. Amorphous Sn oxides were found near the alumina film or formed enclosures with alumina film. The melt containing high Sn content was trapped by enclosures, causing more shrinkage pores during solidification. Cracks likely initiated and expanded along these pores and brittle amorphous Sn oxides, deteriorating the mechanical properties. This work suggests not adding Sn to various Al alloys when used in a cast state.
Exploring the Potential of Mixed Fourier Series in Signal Processing Applications Using One-Dimensional Smooth Closed-Form Functions with Compact Support: A Comprehensive Tutorial
Authors: Páez-Rueda Carlos-Iván , Fajardo Arturo , Pérez Manuel , Yamhure German , Perilla Gabriel
Published: September 2023

This paper studies and analyzes the approximation of one-dimensional smooth closed-form functions with compact support using a mixed Fourier series (i.e., a combination of partial Fourier series and other forms of partial series). To explore the potential of this approach, we discuss and revise its application in signal processing, especially because it allows us to control the decreasing rate of Fourier coefficients and avoids the Gibbs phenomenon. Therefore, this method improves the signal processing performance in a wide range of scenarios, such as function approximation, interpolation, increased convergence with quasi-spectral accuracy using the time domain or the frequency domain, numerical integration, and solutions of inverse problems such as ordinary differential equations. Moreover, the paper provides comprehensive examples of one-dimensional problems to showcase the advantages of this approach.
The Use of FTIR Spectroscopy as a Tool for the Seasonal Variation Analysis and for the Quality Control of Polysaccharides from Seaweeds
Authors: Vandanjon Laurent , Burlot Anne-Sophie , Zamanileha Elando Fréda , Douzenel Philippe , Ravelonandro Pierre Hervé , Bourgougnon Nathalie , Bedoux Gilles
Published: September 2023

Macroalgae are a potentially novel source of nutrition and biologically active molecules. Proliferative species such as Eucheuma denticulatum, Solieria chordalis (red algae) and Sargassum muticum (brown alga) constitute a huge biomass that can be exploited. In this study, we focus on the extraction of polysaccharides from these three macroalgae species and the characterization of cell wall polysaccharides such as carrageenans, fucoidans and alginates by Fourier Transform Infrared spectroscopy with Attenuated Reflectance Module (FTIR-ATR). The comparison of purified extracts with commercial solutions of fucoidans, alginates or carrageenans shows a strong similarity between the spectra. It demonstrates that the methods of extraction that have been used are also suitable purifying technics. Moreover, it validates infrared spectroscopy as a quick, simple and non-destructive method for the accurate analysis of polysaccharides. The FTIR technique applied to samples collected at different periods of the year allowed us to highlight differences in the composition of fucoidans, alginates and carrageenans. Different classes corresponding to the season can be distinguished by statistical multidimensionnal analysis (Principal Component Analysis) showing that the structure of algal polysaccharides, related to bioactivity, depends on the period of harvest. FTIR results showed that S. chordalis and E. denticulatum possess a dominant type of carrageenan called iota-carrageenan. This type of carrageenan is in the majority when the alga is at maturity in its development cycle. During its growth phase, iota-carrageenan precursors can be detected by FTIR spectra, enabling a better control of the extraction and an application of these compounds in various economic sectors. When the alga E. denticulatum is in its juvenile stage, we found traces of kappa-carrageenan and nu-carrageenan polysaccharides in some extracts.
A “Mix and Match” in Hemochromatosis—A Case Report and Literature Focus on the Liver
Authors: Cobilinschi Claudia Oana , Săulescu Ioana , Caraiola Simona , Nițu Andra Florina , Dumitru Radu Lucian , Husar-Sburlan Ioana , Bălănescu Andra Rodica , Opriș-Belinski Daniela
Published: September 2023

Hemochromatosis is a genetic disorder characterized by increased iron storage in various organs with progressive multisystemic damage. Despite the reports dating back to 1865, the diagnosis of hemochromatosis poses a challenge to clinicians due to its non-specific symptoms and indolent course causing significant delay in disease recognition. The key organ that is affected by iron overload is the liver, suffering from fibrosis, cirrhosis or hepatocellular carcinoma, complications that can be prevented via early diagnosis and treatment. This review aims to draw attention to the pitfalls in diagnosing hemochromatosis. We present a case with multiorgan complaints, abnormal iron markers and a consistent genetic result. We then examine the relevant literature and discuss hemochromatosis subtypes and liver involvement, including transplant outcome and treatment options. In summary, hemochromatosis remains difficult to diagnose due to its symptom heterogeneity and rarity; thus, further education for practitioners of all disciplines is useful in facilitating its early recognition and management.
Herbicides versus Nitrogen Cycle: Assessing the Trade-Offs for Soil Integrity and Crop Yield—An In-Depth Systematic Review
Authors: Brochado Maura Gabriela da Silva , Silva Laryssa Barbosa Xavier da , Lima Alessandro da Costa , Guidi Yure Marin , Mendes Kassio Ferreira
Published: September 2023

The interaction of herbicides in the nitrogen cycle and their consequences on soil health and agricultural production are essential topics in agronomic research. In this systematic review article, we have synthesized recent studies on this subject. The results revealed that the indiscriminate use of herbicides can have negative effects on vital processes in the nitrogen cycle, such as reduced enzymatic activity and microbial respiration. Moreover, herbicides alter the soil microbial composition, affecting nitrogen cycling-related activities. Symbiotic nitrogen fixation is also impaired, resulting in a reduction in the population of nitrogen-fixing bacteria and a decrease in the availability of this nutrient in the soil. These effects compromise soil fertility and the release of nitrogen to plants. Therefore, sustainable agricultural practices must be adopted, considering nitrogen cycling efficiency and the preservation of soil and natural resources. This understanding is crucial for guiding appropriate management strategies aimed at minimizing the negative effects of herbicides on the nitrogen cycle and ensuring soil health and agricultural productivity.
Selenium in Cancer Rehabilitation—A Retrospective Study from a Specialized Clinic
Authors: Pfister Christina , Schoenemann Joerg
Published: September 2023

Background: Micronutrient deficiencies are common at the time of cancer diagnosis and are associated with worse prognosis. Little is known about them in cancer rehabilitation. Methods: Data from routine health-related quality of life (HRQOL) were analyzed at an inpatient cancer rehabilitation center. Rehabilitation patients completed the EORTC QLQ-C30 questionnaire before and after multidisciplinary rehabilitation treatment and three months after discharge. Selenium and zinc status were measured in whole blood at these three time points. In case of selenium deficiency, up to 600 µg selenium per day as sodium selenite was supplemented for three weeks during and for three months after rehabilitation. Results: A total of 271 patients (breast, colon, and pancreatic cancer) were included in the analysis. There was clinically meaningful improvement in many domains of the EORTC QLQ-C30 during rehabilitation. However, the effect often waned in the three months after. Prevalence for selenium deficiency varied between 34 to 90% depending on cancer type (breast < colon < pancreas). In contrast, zinc deficiency was rare. Daily selenium supplementation of 600 µg was more efficient to correct selenium deficiency compared to 300 µg selenium per day. Rehabilitation and increasing selenium status after rehabilitation were associated with improved global quality of life, physical and emotional functioning, and fatigue. In cancer patients with decreasing selenium status, values of global quality of life, physical and emotional functioning, and fatigue were back to the values at the beginning of rehabilitation. Conclusions: Selenium deficiency is common in cancer patients admitted to a cancer rehabilitation clinic. Selenium supplementation during rehabilitation effectively corrected selenium deficiency in most cases. The positive effects of rehabilitation persisted longer when selenium status did not decrease after rehabilitation.
Religious Diversity Predicts Religions’ Population Growth in Tighter (vs. Looser) Cultures: A Study of Personality & Self-Reported Religion across 111 Countries
Authors: Senay Ibrahim
Published: September 2023

It is unclear whether religious affiliations and non-affiliations might grow differently in specific cultural environments populated by individuals with a particular personality profile, or how religious diversity in society might influence such growth. In the present study, mixed-effects analyses of moderated mediation conducted on online data collected from 111 countries (Valid N = 52) and across 4270 individuals (Valid N = 3632) showed that personality factors (Extraversion, Conscientiousness, and Agreeableness) could predict religiously affiliated populations growing faster between the years 2000 and 2015 in tighter (vs. looser) countries, which strictly impose social norms and have a low tolerance for deviant behaviors. This finding suggests that religious affiliations and non-affiliations might grow together in moderately tight–loose countries, supporting religious–secular pluralism. Moreover, the faster growth of religions in tighter cultures was stronger in countries ranking higher on the Religious Diversity Index (RDI), showing that all varieties of religions and faiths might become useful in tighter cultures for keeping an interest in religion alive among individuals with distinct personality profiles while ensuring the pervasiveness of social norms in society, toward furthering multi-religious pluralism and the growth of religious affiliations.
Hmong Spirituality, Nature, and Place
Authors: Zhang Yunjie
Published: September 2023

In this article, I show how the Hmong religion can provide the basis of a novel version of non-human-centered environmentalism. I do this by outlining some of the core doctrines in the Hmong religion and showing what they imply about the value of nature. I then situate the view that is implied by these doctrines into the traditional Western environmental ethics literature on the value of nature. In particular, I argue that the Hmong religion provides a view in environmental ethics that is non-anthropocentric, individualistic, non-egalitarian, and non-biocentric.
Rectangular Amplitude Mask-Based Auto-Focus Method with a Large Range and High Precision for a Micro-LED Wafer Defects Detection System
Authors: He Wenjun , Ma Yufeng , Wang Wenbo
Published: September 2023

Auto-focus technology plays an important role in the Micro-LED wafer defects detection system. How to accurately measure the defocus amount and the defocus direction of the Micro-LED wafer sample in a large linear range is one of the keys to realizing wafer defects detection. In this paper, a large range and high-precision auto-focus method based on a rectangular amplitude mask is proposed. A rectangular amplitude mask without a long edge is used to modulate the shape of the incident laser beams so that the spot shape distribution of the reflected laser beam on the sensor changes with the defocus amount of the wafer sample. By calculating the shape of the light spots, the defocus amount and the defocus direction can be obtained at the same time. The experimental results show that under the 20× microscopy objective, the linear range of the auto-focus system is 480 μm and the accuracy can reach 1 μm. It can be seen that the automatic focusing method proposed in this paper has the advantages of large linear range, high accuracy, and compact structure, which can meet the requirements of the Micro-LED wafer defects detection equipment.
IoT and Ensemble Long-Short-Term-Memory-Based Evapotranspiration Forecasting for Riyadh
Authors: Nauman Muhammad Asif , Saeed Mahlaqa , Saidani Oumaima , Javed Tayyaba , Almuqren Latifah , Bashir Rab Nawaz , Jahangir Rashid
Published: September 2023

Evapotranspiration (ET) is the fundamental component of efficient water resource management. Accurate forecasting of ET is essential for efficient water utilization in agriculture. ET forecasting is a complex process due to the requirements of large meteorological variables. The recommended approach is based on the Internet of Things (IoT) and an ensemble-learning-based approach for meteorological data collection and ET forecasting with limited meteorological conditions. IoT is part of the recommended approach to collect real-time data on meteorological variables. The daily maximum temperature (T), mean humidity (Hm), and maximum wind speed (Ws) are used to forecast evapotranspiration (ET). Long short-term memory (LSTM) and ensemble LSTM with bagged and boosted approaches are implemented and evaluated for their accuracy in forecasting ET values using meteorological data from 2001 to 2023. The results demonstrate that the bagged LSTM approach accurately forecasts ET with limited meteorological conditions in Riyadh, Saudi Arabia, with the coefficient of determination (R2) of 0.94 compared to the boosted LSTM and off-the-shelf LSTM with R2 of 0.91 and 0.77, respectively. The bagged LSTM model is also more efficient with small values of root mean squared error (RMSE) and mean squared error (MSE) of 0.42 and 0.53 compared to the boosted LSTM and off-the-shelf LSTM models.
A Smart Home Digital Twin to Support the Recognition of Activities of Daily Living
Authors: Bouchabou Damien , Grosset Juliette , Nguyen Sao Mai , Lohr Christophe , Puig Xavier
Published: September 2023

One of the challenges in the field of human activity recognition in smart homes based on IoT sensors is the variability in the recorded data. This variability arises from differences in home configurations, sensor network setups, and the number and habits of inhabitants, resulting in a lack of data that accurately represent the application environment. Although simulators have been proposed in the literature to generate data, they fail to bridge the gap between training and field data or produce diverse datasets. In this article, we propose a solution to address this issue by leveraging the concept of digital twins to reduce the disparity between training and real-world data and generate more varied datasets. We introduce the Virtual Smart Home, a simulator specifically designed for modeling daily life activities in smart homes, which is adapted from the Virtual Home simulator. To assess its realism, we compare a set of activity data recorded in a real-life smart apartment with its replication in the VirtualSmartHome simulator. Additionally, we demonstrate that an activity recognition algorithm trained on the data generated by the VirtualSmartHome simulator can be successfully validated using real-life field data.
Dual-Channel Stretchable, Self-Tuning, Liquid Metal Coils and Their Fabrication Techniques
Authors: Motovilova Elizaveta , Ching Terry , Vincent Jana , Shin James , Tan Ek Tsoon , Taracila Victor , Robb Fraser , Hashimoto Michinao , Sneag Darryl B. , Winkler Simone Angela
Published: September 2023

Flexible and stretchable radiofrequency coils for magnetic resonance imaging represent an emerging and rapidly growing field. The main advantage of such coil designs is their conformal nature, enabling a closer anatomical fit, patient comfort, and freedom of movement. Previously, we demonstrated a proof-of-concept single element stretchable coil design with a self-tuning smart geometry. In this work, we evaluate the feasibility of scaling this coil concept to a multi-element coil array and the associated engineering and manufacturing challenges. To this goal, we study a dual-channel coil array using full-wave simulations, bench testing, in vitro, and in vivo imaging in a 3 T scanner. We use three fabrication techniques to manufacture dual-channel receive coil arrays: (1) single-layer casting, (2) double-layer casting, and (3) direct-ink-writing. All fabricated arrays perform equally well on the bench and produce similar sensitivity maps. The direct-ink-writing method is found to be the most advantageous fabrication technique for fabrication speed, accuracy, repeatability, and total coil array thickness (0.6 mm). Bench tests show excellent frequency stability of 128 ± 0.6 MHz (0% to 30% stretch). Compared to a commercial knee coil array, the stretchable coil array is more conformal to anatomy and provides 50% improved signal-to-noise ratio in the region of interest.
Automatic Detection of Dyspnea in Real Human–Robot Interaction Scenarios
Authors: Alvarado Eduardo , Grágeda Nicolás , Luzanto Alejandro , Mahu Rodrigo , Wuth Jorge , Mendoza Laura , Stern Richard M. , Yoma Néstor Becerra
Published: September 2023

A respiratory distress estimation technique for telephony previously proposed by the authors is adapted and evaluated in real static and dynamic HRI scenarios. The system is evaluated with a telephone dataset re-recorded using the robotic platform designed and implemented for this study. In addition, the original telephone training data are modified using an environmental model that incorporates natural robot-generated and external noise sources and reverberant effects using room impulse responses (RIRs). The results indicate that the average accuracy and AUC are just 0.4% less than those obtained with matched training/testing conditions with simulated data. Quite surprisingly, there is not much difference in accuracy and AUC between static and dynamic HRI conditions. Moreover, the beamforming methods delay-and-sum and MVDR lead to average improvement in accuracy and AUC equal to 8% and 2%, respectively, when applied to training and testing data. Regarding the complementarity of time-dependent and time-independent features, the combination of both types of classifiers provides the best joint accuracy and AUC score.
Radio Channel Modelling for VHF System Operating in the Offshore Wind Farms Propagation Environment
Authors: Bronk Krzysztof , Koncicki Patryk , Lipka Adam , Niski Rafał , Wereszko Błażej
Published: September 2023

This article discusses several aspects related to the modeling of the radio channel in the wind farm propagation environment. The first part of the article is filled with the analysis of the ITU-R BT.1893-1 model, which—as will be shown—is also applicable to systems operating in the VHF and UHF bands. The conducted measurement campaign makes it possible to model a radio channel for VHF operating systems in the wind farm propagation environment. Thanks to the obtained results, the authors propose the VHF radio channel model for that environment. Using the software implementation of this model, the authors carry out a detailed simulation analysis of the impact of wind turbines on radio systems operating in the VHF band. The main motivation for this work is the growing importance of the offshore wind energy in general, numerous investments in that area in Poland, and the lack of existing mathematical models regarding the wind farms’ impact on the VHF systems. The VHF band is of special interest here, as this part of the spectrum is utilized by numerous marine administration and border protection radio systems, which can be adversely affected by the wind turbines (due to interference and/or radio shadowing).
A Joint Encryption and Compression Algorithm for Multiband Remote Sensing Image Transmission
Authors: Cao Weijia , Leng Xiaoran , Yu Tao , Gu Xingfa , Liu Qiyue
Published: September 2023

Due to the increasing capabilities of cybercriminals and the vast quantity of sensitive data, it is necessary to protect remote sensing images during data transmission with “Belt and Road” countries. Joint image compression and encryption techniques exhibit reliability and cost-effectiveness for data transmission. However, the existing methods for multiband remote sensing images have limitations, such as extensive preprocessing times, incompatibility with multiple bands, and insufficient security. To address the aforementioned issues, we propose a joint encryption and compression algorithm (JECA) for multiband remote sensing images, including a preprocessing encryption stage, crypto-compression stage, and decoding stage. In the first stage, multiple bands from an input image can be spliced together in order from left to right to generate a grayscale image, which is then scrambled at the block level by a chaotic system. In the second stage, we encrypt the DC coefficient and AC coefficient. In the final stage, we first decrypt the DC coefficient and AC coefficient, and then restore the out-of-order block through the chaotic system to get the correct grayscale image. Finally, we postprocess the grayscale image and reconstruct it into a remote sensing image. The experimental results show that JECA can reduce the preprocessing time of the sender by 50% compared to existing joint encryption and compression methods. It is also compatible with multiband remote sensing images. Furthermore, JECA improves security while maintaining the same compression ratio as existing methods, especially in terms of visual security and key sensitivity.
On the Role of Digital Twins in Data Spaces
Authors: Volz Friedrich , Sutschet Gerhard , Stojanovic Ljiljana , Usländer Thomas
Published: September 2023

Industry 4.0 supports the vision of networked machines in decentralized production plants across the value chain. Hence, it requires highly connected partners exchanging relevant data about products, processes, and production resources. This paper proposes the usage of data spaces and digital twins to enable this Industry 4.0 vision and investigates the building blocks to realize a data space for Industry 4.0, e.g., the integration of digital twins inside the data space based upon the latest specification of the Industry 4.0 Asset Administration Shell. A prototypical implementation shows the feasibility of storing product carbon footprints inside a digital twin and sharing it over a data space with other partners.