bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Production Prediction Model Based on Taylor Expansion Formula
Authors: Ding Xianfeng , Qu Dan , Qiu Haiyan
Published: December 2018

On the basis of the analysis of the cumulative production growth curve model, the model variables are adjusted, and the Taylor formula is expanded on the adjusted model. Then the appropriate expansion order n is selected, and the new model for the prediction of cumulative production is established. Furthermore, the error of the new model is discussed, and the model can theoretically achieve any given precision. The model can forecast oil and gas production, cumulative production, and recoverable reserves. Finally, the example analyses show that the greater the order number (n) is, the smaller the error between the prediction data and the actual data and the greater the correlation coefficient become. Compared with other models, the results show that the model has higher prediction accuracy and wider application range and can be used to forecast the production of oil and gas field.
Enterococcus faeciumTIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood
Authors: Wagner Theresa M. , Janice Jessin , Paganelli Fernanda L. , Willems Rob J. , Askarian Fatemeh , Pedersen Torunn , Top Janetta , de Haas Carla , van Strijp Jos A. , Johannessen Mona , Hegstad Kristin
Published: December 2018

Enterococcus faeciumhas undergone a transition to a multidrug-resistant nosocomial pathogen. The population structure ofE. faeciumis characterized by a sharp distinction of clades, where the hospital-adapted lineage is primarily responsible for bacteremia. So far, factors that were identified in hospital-adapted strains and that promoted pathogenesis of nosocomialE. faeciummainly play a role in adherence and biofilm production, while less is known about factors contributing to survival in blood. This study identified a gene cluster, which includes genes encoding bacterial Toll/interleukin-1 receptor- (TIR-) domain-containing proteins (TirEs). The cluster was found to be unique to nosocomial strains and to be located on a putative mobile genetic element of phage origin. The three genes within the cluster appeared to be expressed as an operon. Expression was detected in bacterial culture media and in the presence of human blood. TirEs are released into the bacterial supernatant, and TirE2 is associated with membrane vesicles. Furthermore, thetirE-gene cluster promotes bacterial proliferation in human blood, indicating that TirE may contribute to the pathogenesis of bacteremia.
Mental Health and Well-Being of University Students in Okinawa
Authors: Ratanasiripong Paul , China Takashi , Toyama Shiho
Published: December 2018

With increasing frequency and severity of mental health issues among university students globally as well as limited studies on the mental health of Japanese university students, this study examined the factors that impact the mental health issues of university students in Okinawa. A total of 441 undergraduate students from 3 universities participated in this cross-sectional study. Average age of participants was 20 (range = 18–46, SD = 2.6). Four factors that significantly predicted depression among university students in Okinawa included self-esteem, family economic status, resiliency, and year in school (R2 = 0.37). Two factors that significantly predicted anxiety included self-esteem and family economic status (R2 = 0.26). Three factors that significantly predicted stress included self-esteem, family economic status, and year in school (R2 = 0.28). This study contributes to the understanding of specific factors that impact depression, anxiety, and stress for this population. University administrators and faculty have an opportunity to implement programs and services to make positive impact that could reduce mental health problems and improve well-being for students on their campuses.
Magnetic Fe3O4@Chitosan Carbon Microbeads: Removal of Doxycycline from Aqueous Solutions through a Fixed Bed via Sequential Adsorption and Heterogeneous Fenton-Like Regeneration
Authors: Bai Bo , Xu Xiaohui , Li Changchuan , Xing Jianyu , Wang Honglun , Suo Yourui
Published: December 2018

The adsorptive removal of antibiotics from aqueous solutions is recognized as the most suitable approach due to its easy operation, low cost, nontoxic properties, and high efficiency. However, the conventional regeneration of saturated adsorbents is an expensive and time-consuming process in practical wastewater treatment. Herein, a scalable adsorbent of magnetic Fe3O4@chitosan carbon microbeads (MCM) was successfully prepared by embedding Fe3O4 nanoparticles into chitosan hydrogel via an alkali gelation-thermal cracking process. The application of MCM composites for the adsorptive removal of doxycycline (DC) was evaluated using a fixed-bed column. The results showed that pH, initial concentration, flow rate, and bed depth are found to be important factors to control the adsorption capacity of DC. The Thomas and Yoon-Nelson models showed a good agreement with the experimental data and could be applied for the prediction of the fixed-bed column properties and breakthrough curves. More importantly, the saturated fixed bed can be easily recycled by H2O2 which shows excellent reusability for the removal of doxycycline. Thus, the combination of the adsorption advantage of chitosan carbon with catalytic properties of magnetic Fe3O4 nanoparticles might provide a new tool for addressing water treatment challenges.
The Effects of Moving Load on the Hydroelastic Response of a Very Large Floating Structure
Authors: Zhu Le , Shao Fei , Xu Qian , Sun Yonggang , Ma Qingna
Published: December 2018

The hydroelastic response of a very large floating structure in regular waves suffering an external moving point load is considered. The linearized velocity potential theory is adopted to describe the fluid flow. To take into account the coupled effects of the structure deformation and fluid motion, the structure is divided into multiple segments and connected by an elastic beam. Then through adding a stiffness matrix arising from the elastic beam into the multiple bodies coupled motion equations, the hydroelastic response is considered. By applying the Fourier transform to the obtained frequency domain coefficients, the motion equation is transformed into the time domain and the external point load is further considered. The accuracy and effectiveness of the proposed method are verified through the comparison with experimental results. Finally, extensive results are provided, and the effects of the moving point load on the hydroelastic response of the very large floating structure are investigated in detail.
Superhydrophilic Smart Coating for Self-Cleaning Application on Glass Substrate
Authors: Syafiq A. , Vengadaesvaran B. , Pandey A. K. , Rahim Nasrudin Abd.
Published: December 2018

In general, superhydrophilic coating on glass substrate possesses water contact angle (WCA) below 10° and contains high self-cleaning properties in outdoor environment as compared to noncoated glass substrate panels. In this study, the superhydrophilic coating behavior on glass substrate has been developed. The micro- and nanosized titanium dioxide (TiO2) particles have been utilized to improve the surface roughness, and the polypropylene glycol (PPG) has been utilized to increase the surface energy of glass substrates. The wettability of coating surface shows the coating possess water contact angle (WCA) as low as 5° and suddenly reduce to 0° after 10 s. Superhydrophilic coated glass clearly shows excellent dirt repellent against dilute ketchup solution due to the absence of dirt streak on the glass surface. Meanwhile, the dirt streak is present on the bare glass surface indicating its weak self-cleaning property. The developed superhydrophilic coating on glass substrate was also found to have great antifog property compared to the bare glass substrate. Superhydrophilic surfaces have showed free tiny droplet even at 130°C of hot boiling bath for 10 min and completely dry after 1 min. The superhydrophilic coating surfaces have demonstrated free water streak after impacting with harsh water spraying for 5 min confirming that the superhydrophilic coating on glass substrate is antiwater streak.
The Design and Implementation of Cardiotocography Signals Classification Algorithm Based on Neural Network
Authors: Tang Haijing , Wang Taoyi , Li Mengke , Yang Xu
Published: December 2018

Mobile medical care is a hot issue in current medical research. Due to the inconvenience of going to hospital for fetal heart monitoring and the limited medical resources, real-time monitoring of fetal health on portable devices has become an urgent need for pregnant women, which helps to protect the health of the fetus in a more comprehensive manner and reduce the workload of doctors. For the feature acquisition of the fetal heart rate (FHR) signal, the traditional feature-based classification methods need to manually read the morphological features from the FHR curve, which is time-consuming and costly and has a certain degree of calibration bias. This paper proposes a classification method of the FHR signal based on neural networks, which can avoid manual feature acquisition and reduce the error caused by human factors. The algorithm will directly learn from the FHR data and truly realize the real-time diagnosis of FHR data. The convolution neural network classification method named “MKNet” and recurrent neural network named “MKRNN” are designed. The main contents of this paper include the preprocessing of the FHR signal, the training of the classification model, and the experiment evaluation. Finally, MKNet is proved to be the best algorithm for real-time FHR signal classification.
Analysis of Construction Auctions Data in Slovak Public Procurement
Authors: Hanák Tomáš , Serrat Carles
Published: December 2018

The requirement for efficient public spending leads contracting authorities to use electronic reverse auctions (e‐RA), a tool that allows achieving financial savings. In this study, we aim to explore the relationships between the different acting e‐RA variables and to check for predictive models in order to infer on the savings amount in construction public procurement. Data on real construction auctions in Slovakia were statistically analysed by means of graphics tools, multiple regression analysis, test, and statistics for measuring the association between categorical variables. The results revealed that one should take the type of contract into account when considering the use of e‐RA. This research provides several implications for purchasing practitioners in the area of construction procurement, especially with regard to the level of competition in the auction and estimation of savings potential. Presented findings aid managerial decision‐making process of e‐RA adoption. At the end, recommended future research directions in the investigated area are outlined.
Binary Morphological Filtering of Dominant Scattering Area Residues for SAR Target Recognition
Authors: Shan Chao , Huang Bin , Li Minggao
Published: December 2018

A synthetic aperture radar (SAR) target recognition method is proposed in this study based on the dominant scattering area (DSA). DSA is a binary image recording the positions of the dominant scattering centers in the original SAR image. It can reflect the distribution of the scattering centers as well as the preliminary shape of the target, thus providing discriminative information for SAR target recognition. By subtracting the DSA of the test image with those of its corresponding templates from different classes, the DSA residues represent the differences between the test image and various classes. To further enhance the differences, the DSA residues are subject to the binary morphological filtering, i.e., the opening operation. Afterwards, a similarity measure is defined based on the filtered DSA residues after the binary opening operation. Considering the possible variations of the constructed DSA, several different structuring elements are used during the binary morphological filtering. And a score-level fusion is performed afterwards to obtain a robust similarity. By comparing the similarities between the test image and various template classes, the target label is determined to be the one with the maximum similarity. To validate the effectiveness and robustness of the proposed method, experiments are conducted on the moving and stationary target acquisition and recognition (MSTAR) dataset and compared with several state-of-the-art SAR target recognition methods.
TET2 Deficiency Sets the Stage for B-cell Lymphoma
Authors: Shingleton Jennifer R. , Dave Sandeep S.
Published: December 2018

TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. In this issue of Cancer Discovery, Dominguez and colleagues report that TET2 function is critical for germinal center exit and plasma cell differentiation, and its deficiency can lead to B-cell lymphoma phenotypes.

See related article by Dominguez et al., p. 1632.
Molecular Characterization of Malignant Mesothelioma: Time for New Targets?
Authors: Aggarwal Charu , Albelda Steven M.
Published: December 2018

Malignant pleural mesothelioma (MPM) is an aggressive lethal malignancy for which very few therapeutic options exist. In this issue of Cancer Discovery, Hmeljak and colleagues report on a comprehensive integrative analysis of histology-independent genomic characteristics of MPM. They confirm previous observations that inactivation of tumor suppressor genes is the predominant oncogenic mechanism. This study provides a scientific rationale for potentially novel therapeutic options, including immune-checkpoint targeting VISTA and small-molecule inhibitors targeting the epigenome, DNA-repair pathways, and aurora kinase.

See related article by Hmeljak et al., p. 1548.
Seeking Synergy of Checkpoint Blockade through TGFβ Inhibition
Authors: Puré Ellen
Published: December 2018

Immunotherapy, including checkpoint blockade, is revolutionizing the treatment of cancers, but efficacy has, however, been limited to a subset of patients and can be of limited duration due to primary and acquired resistance to treatment. An article in this issue shows that inhibiting TGFβ can overcome resistance to blockade of one immune checkpoint, but not another, unless one follows where the mechanism leads.

See article by Zhao et al., p. 1459.
Introduction and Summary of the 2018 Dietary Glutamate Workshop
Authors: Cynober Luc , Fernstrom John D. , Koletzko Berthold , Rietjens Ivonne M.C.M. , Roberts Ashley , Tennant David R. , Tomé Daniel , Vorhees Charles V.
Published: December 2018

The 2018 Dietary Glutamate Workshop was organized and sponsored by the International Glutamate Technical Committee to provide a platform for a broad expert discussion on all relevant aspects of glutamate metabolism and safety in human nutrition. The participants reached a consensus with previous safety evaluations conducted by the global expert bodies, but contradicted the 2017 re-evaluation of dietary glutamates by the European Food Safety Authority, which proposed a group acceptable daily intake (ADI) of 30 mg/kg body weight per day. The participants of the Workshop concluded that the present knowledge on metabolism, kinetics, developmental and general toxicity of dietary glutamates did not warrant a change in the previous ADI of “not specified.”
Review of Glutamate Intake from Both Food Additive and Non-Additive Sources in the European Union
Authors: Tennant David R.
Published: December 2018

Background: Intakes of glutamate can be derived from its natural occurrence as a constituent of proteins, from the presence of free glutamate in certain fermented foods, and from the addition of glutamic acid and glutamates to foods as flavor-enhancing additives. Summary: Intakes of glutamate following hydrolysis of dietary proteins can be as high as 440 mg/kg bw/day for toddlers and small children. High-level intakes of glutamate from its natural occurrence  in foods or from the use of food additives, given very conservative assumptions about conditions of use, are ­similar at around 80 mg/kg bw/day for toddlers and small children. Key Messages: The use of glutamic acid and glutamates as food additives makes a marginal contribution to total intakes of glutamate from all sources.
Risk Assessment Paradigm for Glutamate
Authors: Roberts Ashley , Lynch Barry , Rietjens Ivonne M.C.M.
Published: December 2018

Background: Re-evaluation of the use of glutamic acid and glutamate salts (referred to as glutamate hereafter) by the European Food Safety Authority (EFSA) proposed a group acceptable daily intake (ADI) of 30 mg/kg body weight (bw)/day. Summary: This ADI is below the normal dietary intake, while even intake of free glutamate by breast-fed babies can be above this ADI. In addition, the pre-natal developmental toxicity study selected by EFSA, has never been used by regulatory authorities worldwide for the safety assessment of glutamate despite it being available for nearly 40 years. Also, the EFSA ignored that toxicokinetic data provide support for eliminating the use of an uncertainty factor for interspecies differences in kinetics. Key Messages: A 3-generation reproductive toxicity study in mice that includes extensive brain histopathology, provides a better point of departure showing no effects up to the highest dose tested of 6,000 mg/kg bw/day. Furthermore, kinetic data support use of a compound-specific uncertainty factor of 25 instead of 100. Thus, an ADI of at least 240 mg/kg bw/day would be indicated. In fact, there is no compelling evidence to indicate that the previous ADI of “not specified” warrants any change.
Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever
Authors: Baltadzhiev Ivan , Popivanova Nedialka
Published: December 2018

Objective: To report a rare case of maculopapular rash on the scalp in a patient with Mediterranean spotted fever (MSF). Clinical Presentation and Intervention: A 58-year-old woman with breast cancer and chemotherapy-induced alopecia contracted MSF. Her clinical features were typical, except for a maculopapular rash covering the scalp. The diagnosis of MSF was confirmed by immunofluorescent assay. The disease had a favorable course and the patient was discharged in good condition. Conclusion: The rash on the scalp described in this report enriches our knowledge on the clinical characteristics of MSF.
РОЛЬ ГЕМОДИНАМІЧНИХ ПРОЦЕСІВ У ЗМІНАХ МАТКИ ПІД ЧАС ПОЛОГІВ У ВАГІТНИХ ІЗ ПЕРВИННОЮ АРТЕРІАЛЬНОЮ ГІПОТОНІЄЮ
Authors: Popovytch A. , Markin L. B.
Published: December 2018

Мета дослідження – вивчити вплив внутрішньоматкових гемодинамічних процесів на перебіг пологів у роділь із первинною артеріальною гіпотонією (ПАГ).

Матеріали та методи. Методом зовнішньої токографії досліджено скоротливу активність матки в 50 роділь із ПАГ та 25 жінок з неускладненим перебігом термінових пологів. Скоротливу активність матки визначали в динаміці І періоду пологів: у латентну фазу при розкритті шийки матки до 4 см; розкритті маткового вічка – 5–6 та 7–10 см. Проводили динамічне ультразвукове дослідження величини найбільшого поперечного розміру крайового синуса плаценти (мм). Доплерометричне дослідження матково-плацентарного кровоплину включало оцінку кровотоку в маткових артеріях (МА).

Результати дослідження та їх обговорення. У роділь із ПАГ відмічається достовірне збільшення тривалості латентної фази, ІІ періоду пологів та, відповідно, загальної тривалості пологів (р<0,05). Методом зовнішньої токографії виявлено зниження в 1,5 раза базального внутрішньоматкового тонусу в активну фазу пологів у жінок групи спостереження. У динаміці пологового процесу інтенсивність перейм, їх кількість за 10 хв достовірно менші в жінок зі зниженим АТ, а інтервал між переймами у даній групі довший в 1,5–2 рази. Величина маткової активності в латентну фазу пологів у 3 рази, а в активну – в 1,5 раза нижча, ніж у контрольній групі. При вивченні ролі гемодинамічних процесів у виникненні гіпотонічної дисфункції матки в роділь із ПАГ встановлено, що індекси судинного опору в правій і лівій МА були достовірно вищими, ніж у контрольній групі, з переважанням змін у правій МА, що, як відомо, має перевагу в кровопостачанні матки. Останнє зумовлювало підтримання високого преплацентарного опору течії крові, обмеження об’єму крові, що потрапляла в інтервільозний простір, крайовий синус і судинний резервуар міометрія. У роділь із ПАГ поперечний розмір крайового синуса плаценти був достовірно меншим, ніж у контрольній групі спостереження.

Висновок. Активація при гестації вазодилататорних ефектів у вагітних із ПАГ сприяє зниженню систолічної і діастолічної швидкості кровоплину в МА, що зумовлює розвиток недостатності матково-плацентарної перфузії та, як наслідок, уповільнення пологового процесу.
NEW TENDENCIES IN DIAGNOSTICS AND TREATMENT OF DISEASES OF THE CERVIX (LITERATURE REVIEW)
Authors: Boychuk A. V. , Shadrina V. S. , Chlibovska O. I. , Onyskiv B. O. , Fedchenko O. O.
Published: December 2018

In the problem of resolving the pathology of the cervix in recent years, a lot of information about etiology, causes of origin, diagnosis and treatment has been accumulated. The article summarizes the new possibilities of diagnosis and treatment of the pathology of the cervix, which contributes to a significant improvement in the resolution of the problem of the pathology of the cervix. There are 4 main groups of etiologic factors that lead to morphofunctional changes in the cervical epithelium. In the course of a violation of the transformation of the epithelialization of the cylindrical epithelium, the violation of local and humoral immunity is important. The definition of apoptosis index is a new modern method for predicting the development of precancerous and cervical cancer. Routine but informative methods for diagnosing cervical pathologies such as cytological and colposcopic, in recent years, have been replenished with an important immunohistochemical diagnostic method for detecting p161NK4a cellular protein, as well as by fluorescence spectrometry. The presented complex of diagnostic researches allows us to choose the method of adequate treatment of pathological processes taking into account the age of the patient, the nature and degree of severity of epithelial changes, the type of cervical and vaginal flora, as well as the hormonal status of the patient and concomitant pathology.
ПРОФІЛАКТИКА ПОСТОВАРІОЕКТОМІЧНИХ УСКЛАДНЕНЬ У ЖІНОК ІЗ МЕТАБОЛІЧНИМ СИНДРОМОМ
Authors: Polishchuk I. P.
Published: December 2018

Мета дослідження – довести доцільність терапії постоваріоектомічного синдрому в даної категорії хворих сумішшю омега-3 поліненасичених жирних кислот та протодіосцином.

Матеріали та методи. Під спостереженням перебували жінки з метаболічним синдромом при проведенні планової гістерооваріоектомії та протягом 3 місяців запропонованої терапії. В дослідженні використовували такі методи: клінічні, біохімічні, гемостазіологічні та статистичні.

Результати дослідження та їх обговорення. В результаті дослідження доведено, що в жінок із метаболічним синдромом після гістерооваріектомії основні синдроми гіперкоаагуляції і дисліпідемії, котрі призводять до атерогенних катастроф, достовірно ефективно корегуються призначенням суміші омега-3 поліненасичених жирних кислот та протодіосцином.

Висновки. Проведення гістерооваріектомії суттєво підвищує ризик розвитку критичних серцево-судинних ускладнень у жінок із метаболічним синдром. Дані проведеного дослідження свідчать, що препарати з сумішшю омега-3 поліненасичених жирних кислот та протодіосцину слід використовувати з метою попередження менопаузальних ускладнень.
ПОЛІПОЗНА ТРАНСФОРМАЦІЯ ЕНДОМЕТРІЯ: ОСОБЛИВОСТІ ДІАГНОСТИКИ В ЖІНОК ІЗ НЕПЛІДДЯМ
Authors: Chornenka H. M. , Kuzyk Yu. I.
Published: December 2018

Мета дослідження – з’ясувати частоту розбіжності та збігу в діагностиці поліпів ендометрія в жінок репродуктивного віку.

Матеріали та методи. Обстежено 43 пацієнтки репродуктивного віку з поліпами ендометрія (ультрасонографічне дослідження матки, біопсія чи вишкрібання ендометрія). Вік пацієнток коливався від 23 до 43 років.

Результати дослідження та їх обговорення. І клінічну групу становили 33 пацієнтки із непліддям. До ІІ клінічної групи включено 10 жінок без репродуктивних розладів. Сонографічно виділено такі види поліпів: залозистий – 15 випадків, залозисто-фіброзний – 26 та фіброзний – два випадки. При перевазі залозистого компонента точність діагностики сягала 89 %, а при стромальній перевазі – 100 %. Залозисті поліпи діагностували у 82 % випадків. Патоморфологічно в І клінічній групі переважали залозисто-фіброзні поліпи (21 випадок). Серед них найбільше поліпів із перевагою стромального компонента. В ІІ групі переважав залозистий компонент поліпа. При первинному неплідді характерні залозисті поліпи, при вторинному – залозисто-фіброзні із перевагою стромального компонента. Поліпи із перевагою залозистого компонента переважали в жінок ІІ групи – сім випадків, а із перевагою стромального компонента – в жінок І клінічної групи – 13 випадків. Фіброзні поліпи зустрічалися лише в жінок І клінічної групи. В більшості випадків (74,6 %) спостерігалися ознаки хронічного запалення.

Висновки. Найскладнішими для УЗД є фіброзні поліпи у поєднанні із гіперплазією ендометрія, які сприймаються як фіброміома матки. Наявність включень підвищеної ехогенності в залозистих та залозисто-фіброзних поліпах ендометрія є причиною зниження рівня їх діагностики. Для поліпів ендометрія характерна запальна лімфоцитарна інфільтрація строми, що свідчить на користь хронічних ендометритів. У жінок із непліддям виникають залозисті та залозисто-фіброзні поліпи із перевагою фіброзного компонента, спільною рисою яких є виразне фіброваскулярне ядро.
ОСУЧАСНЕННЯ КОНСУЛЬТАТИВНО-ЛІКАРСЬКОЇ ДОПОМОГИ ДІТЯМ НА ПЕРВИННОМУ РІВНІ
Authors: Zaporozhan S. Y. , Vorontsova T. O. , Volyanska L. A. , Krytsky I. O. , Sinitska V. O. , Burbela E. I.
Published: December 2018

Мета дослідження – оптимізувати лікувально-діагностичну допомогу дітям на первинному рівні за умов перехідного періоду на сучасному етапі медичної реформи.

Матеріали та методи. Для оцінки медичної активності батьків у родинах, в яких діти мають хронічну соматичну патологію, проведено анкетування батьків. З метою наближення висококваліфікованої медичної допомоги було створено на основі колективу кафедри дитячих хвороб і дитячої хірургії Тернопільського державного медичного університету імені І. Я. Горбачевського спеціалізовану педіатричну мобільну бригаду.

Результати дослідження та їх обговорення. Досвід роботи спеціалізованої педіатричної мобільної бригади показав, що напрямки її діяльності можуть бути різноманітними: співпраця з «Клінікою на колесах» Міжнародного благодійного фонду «Дар життя», виїзди для медоглядів у школи і дитячі садки, медогляди спільно з лікарями ЦРЛ області, завдяки чому діти отримують висококваліфіковану мультидисциплінарну консультативно-лікувальну допомогу. Проведення освітніх бесід та лекцій безпосередньо з батьками хворих дітей підвищує їх відповідальність за здоров’я дитини, зобов’язує виконувати медичні приписи і призначення, гігієнічні рекомендації та проводити лікувальне харчування.

Висновки. Високий відсоток уперше виявленої серед оглянутих дітей патології та скерування на стаціонарне лікування є показником ефективності такої роботи. Збільшився відсоток самозвернення батьків в обласну дитячу поліклініку з регіонів, де працювала спеціалізована педіатрична мобільна бригада. Інновацією даної бригади стало поєднання первинної і третинної ланок надання медичних послуг, що підвищує ефективність нагляду за здоров’ям дітей.
ОСОБЛИВОСТІ КРОВОПОСТАЧАННЯ ЕНДОМЕТРІЯ У ПАЦІЄНТОК ІЗ БЕЗПЛІДДЯМ ВНАСЛІДОК ЗНИЖЕНОГО ОВАРІАЛЬНОГО РЕЗЕРВУ
Authors: Prodan T. A.
Published: December 2018

Мета дослідження – вивчення стану кровоплину ендометрія в жінок із безпліддям внаслідок зниженого оваріального резерву з невдалими спробами ЕКЗ.

Матеріали та методи. Було обстежено 120 пацієнток репродуктивного віку з безпліддям у зв’язку зі зниженим оваріальним резервом та невдалими спробами ЕКЗ. Всі жінки були розподілені на дві групи: основну (n=60) та порівняння (n=60). В кожній групі були дві підгрупи: підгрупи пацієнток зі зниженим оваріальним резервом у зв’язку з оперативними втручаннями на яєчниках в минулому та підгрупи з генетично зниженим оваріальним резервом. Для визначення стану ендометрія використовували двовимірну та тривимірну ехографію й тривимірну енергетичну доплерографію. Дослідження проводили на 7-й день менструального циклу, що передував кріоембріотрансферу.

Результати дослідження та їх обговорення. Автором не було зареєстровано різниці між підгрупами за об’ємом ендометрія ((2,21±0,03); (2,23±0,04); (2,28±0,06) та (2,17±0,06) см3 відповідно по підгрупах, p>0,05) й індексом васкуляризації ((12,23±1,19); (14,09±1,31); (11,84±1,54) та (12,56±1,43) % відповідно до підгруп, p>0,05). У той час як індекс кровоплину був менший за такий, вказаний у літературі, в гінекологічно здорових жінок. Визначення васкуляризаційно-потокового індексу показало його майже трикратне зниження порівняно з даними інших авторів у здорових жінок. При цьому вказаний індекс був вірогідно (p<0,05) нижчий у пацієнток із генетично зниженим оваріальним резервом (0,82±0,03 та 0,87±0,03) порівняно з жінками, у яких оваріальний резерв був знижений внаслідок оперативних втручань (1,06±0,03 та 1,11±0,04).

Висновок. Жінки з безпліддям на тлі зниженого оваріального резерву мають значно гірше кровопостачання ендометрія, ніж здорові жінки, але у пацієнток з оперованими яєчниками воно краще порівняно з жінками з генетично обумовленним зниженням оваріального резерву.
OBSTETRIC AND PERINATAL OUTCOMES IN PREGNANCY WITH DIFFERENT SEVERITY AND TIME OF THE MANIFESTATION OF PREECLAMPSIA
Authors: Amor M. B. , Gnatko O. P. , Skuriatina N. G.
Published: December 2018

The aim of the study – to conduct a retrospective analysis of the course of pregnancy and delivery to determine the nature of obstetric and perinatal complications in preeclampsia.

Materials and Methods. The analysis was based on the results of the evaluation of the medical documentation (individual medical records of the pregnant woman, birth histories, developmental histories of the newborn) in 224 pregnant women with preeclampsia and 80 pregnant women without preeclampsia. In addition to the results of the clinical and laboratory examination, the analysis included the severity of preeclampsia and the time of clinical manifestations. The results of the study were statistically processed by methods of mathematical analysis with the determination of the mean values ​​(M ± m), Student's t-test and significance factor (р˂0.050 difference was statistically significant.

Results and Discussion. According to the results of the analysis, mild preeclampsia was found in 32.6 % of cases, modera­te PE – in 37.5 %, severe PE – in 29.9 % of cases. The early onset of PE (up to 34 weeks) was observed in 35.7 % of pregnant women, and later onset (after 34 weeks) in 64.7 %. The analysis of the incidence of early and late PE cases at various severity levels showed that, in the case of early PE, severe disease was 2.9 times more frequent, and the moderate disease was 2.7 times more frequent than the mild disease. In the late PE, the mild PE was 1.9 times more frequent than the severe PE and 1.2 times more frequent than the moderate PE. In addition to PE, 31.7 % of women had other complications of pregnancy. The most common complications include asymptomatic bacteriuria (16.9 %), abnormal placental location (14.1 %), placental dysfunction (32.4 %), and fetal growth retardation (21.1 %). Term delivery occurred in 81.6 % of cases, premature births were in 18.3 %. Complications include premature rupture of membranes, anomalies of labor, premature detachment of the normally located placenta, postpartum hemorrhage. Among perinatal complications, fetal growth retardation, hemodynamic disorders, fetal distress, newborn asphyxia have been observed. The adverse outcome for a child in severe PE was 3 times higher than for mild PE.

Conclusion. The analysis showed that obstetric and perinatal outcomes in preeclampsia are associated with the time of this pregnancy complication and its severity.
A Gestão Ordinária e suas práticas: o caso da Cafeteria Will Coffee
Authors: Carrieri Alexandre De Pádua , Perdigão Denis , Martins Paula Gontijo , Aguiar Ana Rosa Camillo
Published: December 2018

O presente artigo tem por objetivo contribuir para o entendimento do conceito de gestão ordinária (Carrieri, Perdigão & Aguiar, 2014), por meio do estudo de uma pequena organização familiar, a Cafeteria Will Coffee. A gestão ordinária não é apresentada como um ‘modelo’ alternativo de gestão, tão pouco como um método formal de pesquisa, mas como uma crítica aos modelos e postulados gerenciais dominantes, que buscam simplificar a realidade complexa do ambiente sócio-organizacional. Ao tomar como caso de estudo uma cafeteria aberta em um bairro operário de Contagem (MG), cujas peculiaridades tornaram sua história pública, noticiada em diversos veículos da mídia jornalística e especializada, busca-se evidenciar e ressaltar aspectos rotineiramente silenciados, desprezados, ou apagados das complexas narrativas que não cabem nos modelos habituais, como a espontaneidade, o não planejamento e a improvisação. Conclui-se que a gestão ordinária colabora com a área de Estudos Organizacionais ao possibilitar a recuperação de outras experiências de gestão, dando voz aos ‘sujeitos’ comuns e se interessando por suas histórias, discursos, e práticas, recuperando o direito de eles serem vistos como gestores e produtores de conhecimento.
2018 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Authors: Duff Jonathan P. , Topjian Alexis , Berg Marc D. , Chan Melissa , Haskell Sarah E. , Joyner Benny L. , Lasa Javier J. , Ley Sondra J. , Raymond Tia T. , Sutton Robert M. , Hazinski Mary Fran , Atkins Dianne L.
Published: December 2018

This 2018 American Heart Association focused update on pediatric advanced life support guidelines for cardiopulmonary resuscitation and emergency cardiovascular care follows the 2018 evidence review performed by the Pediatric Task Force of the International Liaison Committee on Resuscitation. It aligns with the International Liaison Committee on Resuscitation’s continuous evidence review process, and updates are published when the group completes a literature review based on new published evidence. This update provides the evidence review and treatment recommendation for antiarrhythmic drug therapy in pediatric shock-refractory ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest. As was the case in the pediatric advanced life support section of the “2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care,” only 1 pediatric study was identified. This study reported a statistically significant improvement in return of spontaneous circulation when lidocaine administration was compared with amiodarone for pediatric ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest. However, no difference in survival to hospital discharge was observed among patients who received amiodarone, lidocaine, or no antiarrhythmic medication. The writing group reaffirmed the 2015 pediatric advanced life support guideline recommendation that either lidocaine or amiodarone may be used to treat pediatric patients with shock-refractory ventricular fibrillation or pulseless ventricular tachycardia.
Associations of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Mass Index With Mortality and Cardiovascular Outcomes in the General Population
Authors: Kim Mee Kyoung , Han Kyungdo , Park Yong-Moon , Kwon Hyuk-Sang , Kang Gunseog , Yoon Kun-Ho , Lee Seung-Hwan
Published: December 2018

Background:

Variability in metabolic parameters, such as fasting blood glucose and cholesterol concentrations, blood pressure, and body weight can affect health outcomes. We investigated whether variability in these metabolic parameters has additive effects on the risk of mortality and cardiovascular outcomes in the general population.

Methods:

Using nationally representative data from the Korean National Health Insurance System, 6 748 773 people who were free of diabetes mellitus, hypertension, and dyslipidemia and who underwent ≥3 health examinations from 2005 to 2012 were followed to the end of 2015. Variability in fasting blood glucose and total cholesterol concentrations, systolic blood pressure, and body mass index was measured using the coefficient of variation, SD, variability independent of the mean, and average real variability. High variability was defined as the highest quartile of variability. Participants were classified numerically according to the number of high-variability parameters (eg, a score of 4 indicated high variability in all 4 metabolic parameters). Cox proportional hazards models adjusting for age, sex, smoking, alcohol, regular exercise, income, and baseline levels of fasting blood glucose, systolic blood pressure, total cholesterol, and body mass index were used.

Results:

There were 54 785 deaths (0.8%), 22 498 cases of stroke (0.3%), and 21 452 myocardial infarctions (0.3%) during a median follow-up of 5.5 years. High variability in each metabolic parameter was associated with a higher risk for all-cause mortality, myocardial infarction, and stroke. Furthermore, the risk of outcomes increased significantly with the number of high-variability metabolic parameters. In the multivariable-adjusted model comparing a score of 0 versus 4, the hazard ratios (95% CIs) were 2.27 (2.13–2.42) for all-cause mortality, 1.43 (1.25–1.64) for myocardial infarction, and 1.41 (1.25–1.60) for stroke. Similar results were obtained when modeling the variability using the SD, variability independent of the mean, and average real variability, and in various sensitivity analyses.

Conclusions:

High variability of fasting blood glucose and total cholesterol levels, systolic blood pressure, and body mass index was an independent predictor of mortality and cardiovascular events. There was a graded association between the number of high-variability parameters and cardiovascular outcomes.
Five new deep-sea species of nudibranchs (Gastropoda: Heterobranchia: Cladobranchia) from the Northeast Pacific
Authors: VALDÉS ÁNGEL , LUNDSTEN LONNY , WILSON NERIDA G.
Published: December 2018

Increased exploration of northeastern Pacific deep-sea habitats has revealed a diverse and often poorly-known invertebrate community, including a number of undescribed species of nudibranchs studied herein. We used morphology to distinguish several new species from their congeners, and generated data where possible for mitochondrial (COI, 16S) and nuclear markers (H3) to place them in a phylogenetic context. We described here Tritonia nigritigris sp. nov., Dendronotus claguei sp. nov., Ziminella vrijenhoeki sp. nov., Cuthona methana sp. nov., Aeolidia libitinaria sp. nov. and redescribed Zeusia herculea (Bergh, 1894). Another species of Tritonia is described but not named due to the absence of reproductive system information. Although there are difficulties in collection from deep-sea habitats, only two of our new species are known from single specimens. As with many other deep-sea regions, we expect the number of new species from this region to increase with further exploration. Because the deep regions of the northeast Pacific are particularly vulnerable to the effects of decreasing oxygenation due to climate change, we consider that documenting this fauna has some level of urgency.
А new species of Alona Baird, 1843 (Cladocera: Chydoridae) from the ancient Lake Ohrid
Authors: SINEV ARTEM Y. , LÓPEZ-BLANCO CHARO
Published: December 2018

A new species of Cladocera, Alona begoniae sp. nov. (Anomopoda: Chydoridae) was found in ancient Lake Ohrid. Its habitus and outer morphology is similar to one of the most common Palearctic species, Coronatella rectangula (Sars, 1862), and this can be the main reason why it has remained undiscovered. A. begoniae sp. nov. belongs to the elegans-group of Alona s. lato, a relict genus-level group not formally recognised yet as a separate taxonomical unit. Its habitat appears to be sandy and stony substrates (at 2–12 m depth) bare of vegetation. The position of this new species within the Alona-like anomopods is evaluated and similarities with other cladocerans in ancient lakes are discussed.
The larvae of Rhyacophila rougemonti McLachlan 1880, Rhyacophila trifasciata Mosely 1930, Rhyacophila pallida Mosely 1930, and Rhyacophila tarda Giudicelli 1968 (Trichoptera: Rhyacophilidae), including a discriminatory matrix to the Rhyacophila larvae with tetrafilament abdominal gills from Italy and Corsica
Authors: WARINGER JOHANN , MALICKY HANS
Published: December 2018

This paper gives a description of the hitherto unknown or poorly known larvae of Rhyacophila rougemonti McLachlan 1880, R. trifasciata Mosely 1930, R. pallida Mosely 1930, and R. tarda Giudicelli 1968 (Trichoptera: Rhyacophilidae). Information on the morphology of the larvae is provided, and the most important diagnostic features are figured. This dataset is included in a discriminatory matrix of the Rhyacophila larvae with tetrafilament (i.e., four-filament) abdominal gills of Italy and Corsica described so far; only the species pair Rhyacophila pallida / R. tarda in Corsica remains unresolved. Larvae can be separated by the number of metathoracic gill filaments and anal proleg morphology, and by distribution patterns. Endemism is high in the species quartet described in the present paper: Rhyacophila pallida and R. trifasciata are Sardo-Corsican endemic species, R. tarda is restricted to Corsica, and R. rougemonti is a South-Apennine endemic species.
A new species and a new record of genus Hexacentrus Serville, 1831 (Orthoptera: Tettigoniidae: Hexacentrinae) from India
Authors: FAROOQI MOHD KALEEMULLAH , USMANI MOHD KAMIL
Published: December 2018

The paper deals with a new record Hexacentrus japonicus Karny, 1907 and a new species Hexacentrus bifurcata sp. nov. from India. Necessary and important illustrations with SEM images of stridulatory file of Hexacentrus japonicus and Hexacentrus bifurcata sp. nov. are provided. A key to the Indian species of Hexacentrus and morphometric ranges of all the species have also been included. Type specimens have been preserved for further investigation in Zoology Department, Aligarh Muslim University (ZDAMU).
Four new species of the genus Miridiba Reitter (Coleoptera: Scarabaeidae: Melolonthinae) from China
Authors: GAO CHUAN-BU , BAI MING , FANG HONG , YU ZHI-GUO
Published: December 2018

Four new species of the genus Miridiba Reitter, 1902 from South China are described and illustrated: Miridiba (Miridiba) bannaensis Gao & Fang, new species, M. (M.) kuatunensis Gao & Fang, new species, M. (M.) xingkei Gao & Fang new species and M. (M.) youweii Gao & Fang, new species. Miridiba (M.) tuberculipennis obscura Itoh, 1995 is raised to species level. Miridiba (M.) obscura Itoh, 1995 and M. (M.) tuberculipennis (Moser, 1913) are newly recorded for China. A catalogue of Miridiba species from China is provided. [Zoobank registrations: Miridiba bannaensis Gao & Fang, new species: LSID: urn:lsid:zoobank.org:act:0AEA5EFC-0914-437A-AEF6-C2685247E427 Miridiba kuatunensis Gao & Fang, new species: LSID: urn:lsid:zoobank.org:act:148F9BA8-5666-40DC-A209-25C4B68D5CD5 Miridiba xingkei Gao & Fang, new species: LSID: urn:lsid:zoobank.org:act:65A3141D-C7AC-4E89-BB20-5F5CFFA4D58E Miridiba youweii Gao & Fang, new species: LSID: urn:lsid:zoobank.org:act:DDA98D6C-5753-4F82-A49A-D9C7913DCFC2]
Remarks on the genus Metacosma Kuznetzov, 1985 (Lepidoptera: Tortricidae, Olethreutinae, Eucosmini), with description of a new species from Japan and Korea
Authors: KOMAI FURUMI , BYUN BONG-KYU , YAMAZAKI SABURO
Published: December 2018

Metacosma Kuznetzov, 1985 is briefly reviewed and its affinities within Eucosmini are discussed. A checklist of species is presented, including a species of questionable generic assignment, M. miratorana Kuznetzov, 1988. One new species, M. echinophora Komai, Byun & Yamazaki, is described from Japan and Korea. In Japan this species is a minor pest in pine plantations. Its larva bores into needles and buds of pines (Pinus spp.), forming a resin dome as a shelter. Photographs of the adult, the genitalia of both sexes, and the larval habitat, along with line drawings of the wing venation, the larva, and the pupa are provided.
A new species of African snake-eyed skink (Scincidae: Panaspis) from central and northern Namibia
Authors: CERÍACO LUIS M. P. , BRANCH WILLIAM R. , BAUER AARON M.
Published: December 2018

A recent molecular revision of the snake-eyed skinks of the genus Panaspis Cope, 1868 uncovered extensive cryptic diversity within the P. wahlbergi (Smith, 1849) and P. maculicollis Jacobsen & Broadley, 2000 species complexes. We here describe an unnamed central and northern Namibian lineage of the P. maculicollis group as a new species. We base the description on previously published molecular evidence and newly collected morphological, meristic and coloration data. Members of the group share a conservative morphology and the newly described species is very similar to P. maculicollis, from which it differs mostly on the basis of its coloration. This description raises the number of Panaspis recognized to 17 species and reinforces the already strong evidence that northern Namibia is a hotspot of reptile diversity.
New species of the snakefly genus Mongoloraphidia (Raphidioptera: Raphidiidae) from China
Authors: LIU XINGYUE , LYU YANAN , ASPöCK HORST , ASPÖCK ULRIKE
Published: December 2018

Two new snakefly species of the family Raphidiidae are described from China: Mongoloraphidia lini sp. nov. and Mongoloraphidia triangulata sp. nov. Biogeographical considerations on secondary refugial centers of the large Sino-Tibetan primary center are presented.