bluuebunny/crossref_metadata_2025 huggingface dataset:
El próximo paso en la personalidad jurídica de las empresas: Las empresas como Ciudadanos
Authors: Chinchilla Fuentes Luis Ovidio
Published: March 2023

Este artículo busca—mediante un análisis histórico, filosófico y dogmático—proveer argumentos legales, morales y filosóficos para evolucionar el concepto de personalidad jurídica empresarial al de ciudadanía corporativa. Al enfocarse en el derecho corporativo anglosajón, este trabajo evidencia como el concepto de ciudanía permite limitar los impactos negativos de las empresas en los derechos humanos y arraigarlas a una jurisdicción. El presente articulo brinda soluciones innovadoras respecto de los abusos empresariales frente a los derechos humanos de las comunidades donde operan. El concepto de ciudanía corporativa aquí propuesto evoca mayores deberes morales hacia los conciudadanos tanto a nivel local, regional y global. La idea de ciudadanía corporativa evoca la creación de un marco jurídico nacional y supra nacional de gobernanza que recalibre los derechos y las responsabilidades de las empresas como ciudadanos. En definitiva, este trabajo es una crítica al actual status quo de las empresas como persona jurídica.
Interpretación judicial y garantía de los derechos: El valor de la uniformidad
Authors: Bruzón Viltres Carlos Justo , Rivero Reyes Dannis María
Published: March 2023

La tutela de los derechos humanos constituye un imperativo en cualquier ordenamiento jurídico. Es fundamento de la sociedad democrática. Los sistemas de garantías han ido evolucionando y se perfeccionan, constituyendo las de carácter jurisdiccional una de las más importantes. Por tanto, la interpretación que realizan los jueces adquieren una relevancia incontestable y la uniformidad de estos criterios tutelares, una garantía adicional en la protección de los derechos, lo cual reafirma el valor de la jurisprudencia como fuente del Derecho. Sobre la relevancia de este hecho se enfoca el presente artículo, empleando una metodología esencialmente cualitativa, analítica y descriptiva
HAK ASASI MANUSIA DALAM PANDANGAN ISLAM
Authors: Pitriani Pitriani
Published: March 2023

Normally, the position of the human person with all the rights of the most fundamental has gained recognition in the Declaration and the International Covenants. Human rights have become values and norms in international relations. This is shown by the agreement of all countries, at least in countries that are members of the United Nations to the United Nations Charter, the Universal Declaration of Human Rights (1948). Islam as a religion and its teachings are universal and comprehensive, encompassing faith, worship, and mu'amalat, each of which contains the doctrine of the faith; religious dimension to the teachings of the mechanisms of human devotion to God; with either the doctrine of man's relationship with fellow humans and to the environment. Each dimension is based on the teachings of the provisions referred to by the term Sharia or Islamic jurisprudence. In the context of law or jurisprudence there are teachings on Human Rights (HAM). The existence of the doctrine of human rights in Islam shows that Islam as a religion has placed man as honorable and noble creatures. Therefore, the protection and respect for the human being is the claim of Islam itself must be carried out by Muslims against fellow human beings without exception.Secara normatif, kedudukan pribadi manusia dengan segala hak-haknya yang paling asasi telah memperoleh pengakuan dalam Deklarasi dan Kovenan-kovenan internasional. Hak-hak asasi manusia telah menjadi nilai dan norma dalam hubungan internasional. Hal ini ditunjukkan oleh persetujuan semua negara, setidak-tidaknya negara-negara yang menjadi anggota PBB terhadap piagam PBB, Deklarasi Universal tentang Hak-Hak Asasi Manusia (1948).Islam sebagai sebuah agama dengan ajarannya yang universal dan komprehensif meliputi akidah, ibadah, dan mu’amalat, yang masing-masing memuat ajaran tentang keimanan; dimensi ibadah memuat ajaran tentang mekanisme  pengabdian manusia terhadap Allah; dengan memuat ajaran tentang  hubungan manusia dengan sesama manusia maupun dengan alam sekitar. Kesemua demensi ajaran tersebut dilandasi oleh ketentuan-ketentuan yang disebut dengan istilah syari’ah atau fikih.Dalam konteks syari’at atau fikih itulah terdapat ajaran tentang Hak Asasi Manusia (HAM).Adanya ajaran tentang HAM dalam Islam menunjukkan bahwa Islam sebagai agama telah menempatkan manusia sebagai makhluk terhormat dan mulia.Karena itu, perlindungan dan penghormatan terhadap manusia merupakan tuntutan dari ajaran Islam itu sendiri yang wajib dilaksanakan oleh umatnya terhadap sesama manusia tanpa kecuali.
Severity of Symptoms and Mortality in Diabetic Patients with COVID- 19 Infection. Review
Authors: Zahraa ALBasry  , Abeer Abdulhadi Rashid  , Shaymaa Hasan Abbas
Published: March 2023

Background: COVID-19 pneumonia is an illness that was spreading rapidly around the world and causes many deaths. Diabetes, is considered as a risk factor which adds severity and mortality to COVID-19 infected persons. There are many studies aiming to explain the

 exact association between diabetes and COVID-19.  This review aims to link between diabetes and COVID-19 risk factors, discuss the  management of patients with diabetes and COVID-19 and  provide perception into the COVID-19 disease complications relevant to diabetes .In this  review, many scientific articles and reports about COVID- 19 and Type 2 DM were collected from different databases (e.g., PubMed, Google Scholar, and Web of Science) using keywords such as SARS-CoV2, COVID-19, TYPE 2 DM, Mortality, and CO-morbidities .The result  from this study found that diabetic patients has poor prognosis, severe symptoms, worsen outcomes, and the mortality rate is higher among COVID-19 patients who have diabetes mellitus. Many complications associated with diabetes like peripheral neuropathy and vascular insufficiency can make patients more susceptible to infections. One of the sever complication of Covid-19 infection is, the cytokine storm, that result in excessive release of inflammatory cytokines (TNF-a, IL-6, IL-10), and this may be aggravated by the inflammatory process together with the hyper-coagulable condition in diabetic patients. In conclusion: Hyperglycemia is established as risk factor for increased morbidity and mortality in covid 19 infection.
Mucoadhesive Film Forming Spray for Buccal Drug Delivery: A Review
Authors: Reem Wael Shahadha  , Nidhal Khazaal Maraie
Published: March 2023

Film-forming sprays provide a number of advantages over conventional topical treatments, including equal medication distribution and dosing, increased bioavailability (increase local drug concentration), and less irritability (Dosing frequency). Polymers and excipients that improve the characteristics of preparations and increase the stability of active substances are the building blocks of mucoadhesive film-forming sprays. Films made from diverse combinations of polymer and excipient exhibited a wide range of characteristics. This reveiw examines the many types of polymers and excipients, the different types of sprayers, the different evaluations, as well as the essential criteria that are involved in defining the sprayability and film properties. This comes to the conclusion that natural and synthetic polymers with viscoelastic properties can both be employed to optimize the administration of buccal drugs.
Effectiveness of Acupressure Therapy against Constipation and comfort Cancer Patients Undergoing Chemotherapy: Systematic Review
Authors: Dewi Siti Utami , Nuraeni Tuti , Maria Riri , Gayatri Dewi
Published: March 2023

The complex state of cancer causes sufferers to face a variety of clinical symptoms, both physically and psychologically, dramatically affecting the Patient's daily life. Chemotherapy treatment or therapy undertaken by cancer patients has severe side effects. Some side effects, such as headache, myalgia, hypotension, urinary retention, and constipation, can cause discomfort in cancer patients. Therefore, complementary acupressure therapy is needed to reduce the symptoms of constipation and pain caused by the symptoms. This study aims to find evidence based on the effectiveness of acupressure therapy for constipation and the comfort of cancer patients undergoing Chemotherapy. The study method uses the eight stages in this review: identifying nursing problems, prioritizing problems and research questions, primary and secondary data frameworks, identifying relevant studies, prism flow diagrams, critical appraisal, data analysis, and data extraction. This review uses five databases with a period of 2013-2022. The search results for the total number of articles obtained were 1,241, and ten were selected for review. Several reports comparing constipation symptoms and comfort levels in the acupressure therapy group and without acupressure therapy showed that acupressure therapy is an effective nonpharmacological therapy to reduce constipation symptoms and discomfort in cancer patients undergoing Chemotherapy. Based on reviews of acupressure therapy's effectiveness in lowering constipation symptoms and distress in cancer patients, more high-quality evidence is needed to determine whether acupressure is more effective than other treatments.
Quality Assessment of Brands and Generic in Atorvastatin Tablets Available in Iraq-thi-Qar
Authors: Alkufi Hussein , Alkanani Abdul_Ghaffar S. , Muhareb Saja H. , Alhamidawi Ahmed K. , Shahad Mathab A. , Abd Sara H.
Published: March 2023

Hypolipidemic agents have been shown to be helpful in the primary and secondary prevention of cardiovascular disease. Statins are frequently administered to treat hyperlipidemia. Although there are many statins on the market today, atorvastatin is the one that is most frequently recommended. The medications must meet the required physical qualities and contain the right quantity of active medicinal components. The primary goal of the study was to assess the value of several brands of atorvastatin calcium tablets sold in Iraq.Methods: In this study, the in vitro dissolving test, disintegration, friability, and hardness tests of the innovator product coded as (AT-1) and the generic brands (coded as AT-2) of atorvastatin tablets 20 mg available in Iraq were assessed. Drug analysis was done using a spectrophotometric technique. At a 240 nm wavelength, atorvastatin was found. The researched products released more than 90% of the atorvastatin in 30 minutes, per the findings of the dissolving testing. In under 30 minutes, the brands AT-1 and AT-2 showed a release of atorvastatin of over 95% and 86%, respectively. Our research revealed that the generic brand AT-2 and the innovator atorvastatin (AT-1) were of high pharmaceutical grade. In vitro dissolution, friability, disintegration, and hardness tests required by the pharmacopoeia were all passed by generic and innovator of atorvastatin tablets sold in the Iraqi market. Therefore, it was concluded that these generics might be utilized interchangeably by focusing on their in vitro release characteristics.
The Curious Stranger: An Approach to Fieldwork
Authors: Perry Kevin , Rasmussen Mette
Published: March 2023

This paper explores the interactions and processes that empower researchers to qualify and change research questions during fieldwork. Turning to the concepts of reflexivity and Simmel’s Stranger gives a valuable understanding of the processes that qualify research projects while they are happening. Reporting on two separate fieldwork studies in Greenland, the paper explores how the researchers respond to unfolding events in the two different Greenlandic contexts. Study A) investigated homelessness in Tasiilaq but changed direction to embrace new national and local developments. A unique opportunity arose due to a broadcast sent via Denmark’s Radio. Consequently, the researcher in the field responded by broadening the interview guide and scope of the study. Study B) discusses how leadership unfolds in fish processing factories in Nuuk and Maniitsoq. The researcher emerged in everyday organisational life, observing day-to-day activities based on participant observations, shadowing, conversations, and interviews.
After effects of military service and training in a soldier’s life
Authors: Maduwanthi AA Ishari , Buddike W Dinesh
Published: March 2023

This paper reviews the possible after-effects of military training given by the Sri Lankan Army to recruits and to existing army personnel who would like to be promoted to the next stage of the hierarchy. It is considered that training personnel is a major task in Sri Lankan Army as the military promotes from within and develops its leaders rather than selecting them from outside their ranks. Therefore, the process of training is expensive, yet it is one of the country’s topmost priorities since army personnel ensures the necessary security schemes in Sri Lanka while maintaining an anti-terror stance. In order to gather the required data, a questionnaire with 15 questions was provided to six retired army personnel who had served below the lieutenant position in Sri Lanka Army. Additionally, those people were interviewed with another set of interview questions in order to find out the differences between the answers they have given in the questionnaire in comparison to the interview. This paper seeks to answer the question of whether there are any after-effects the army personnel experience due to the rigorous training provided by the Sri Lankan Army even after their service period is completed. It also examines whether these effects are positively or negatively related to their daily experiences. It is hoped this study will inform the general public and the ones who are currently serving in the military about the consequences of military training.
The mediating role of electronic word-of-mouth on the relationship between tourism product quality, service quality and tourist revisit intention: A case study
Authors: Sagantoro Rio , Widayanto Widayanto , Wijayanto Andi
Published: March 2023

The development of the tourism industry in a number of areas is increasing, especially in the city of Semarang. Kreo Cave Tourism Object in Semarang City is a natural tourism object that has tourism potential with the beauty of its natural scenery, Kreo Cave is located in the middle of the Jatibarang reservoir, as well as wild monkeys that thrive which are icons in the Kreo Cave tourism objects in Semarang City. This research is motivated by the decline in the number of visitors to the Kreo Cave tourist attraction in recent years. The purpose of this study was to explain the influence of the quality of tourism products and service quality on the revisit intention through electronic word-of-mouth. The type of research used is explanatory research. Data collection technique used a questionnaire, with the sampling technique using purposive sampling. The number of samples was 100 respondents who have visited the Kreo Cave tourism object, Semarang City. Quantitative analysis technique used Partial Last Square (PLS) which is estimated using the WarpPLS 7.0 program. The research found that Electronic Word-of-mouth significantly mediates the effect of Quality of Tourism Products and Quality of Services on Revisit Intention.
Mathematics teacher competency analysis during online learning
Authors: Lumbantoruan Jitu Halomoan , Nadeak Bernadetha
Published: March 2023

This study aims to find out where the difficulty of teacher competence is when implementing online mathematics materials. When online learning mathematics material, many students complain and get low learning outcomes. There are 92% of students have difficulty learning mathematics online. The basis of this problem needs to be analyzed where the difficulty of mathematics teacher competence in online learning. Data collection techniques with observations and shared instruments. The analysis is done by presenting the data, reducing it, and drawing conclusions. Results, 1) Online learning with the 2013 curriculum is still 95%. 2) There is no preparation and only the provision of package books. Student assessment of professional teacher competence 62% disagree and 45% pedagogically disagree, this disagreement is because the module was not prepared by the teacher himself. 3) 57, 14% disagree with the assessment method, the material being tested is more difficult than what is taught, and this is the cause of low learning outcomes. 4) Difficulty operating media, writing symbols, proving, explaining concepts, internet network, and correcting assignments. In conclusion, the difficulty lies in teachers with pedagogical competence with minimal learning aids and professional competence who cannot explain concepts in the media and are not assisted by self-made modules.
Development of mathematics learning devices with a problem based learning model oriented on the mathematics problem solving ability
Authors: Sabilah Meryannav , Yolanda Fitriana
Published: March 2023

The aims of this study is to produce a mathematical learning device with a Problem Based Learning model oriented to mathematical problem-solving abilities on the subject matter of the size of the concentration and distribution of valid and practical data for class VIII SMPN 1 Rengat Barat. This research on the development of mathematics learning tools uses a 4-D model, namely: 1) Define, 2) Design, 3) Develop, and 4) Disseminate. The data collection instruments used were RPP validation questionnaire sheets and LKPD validation questionnaire sheets and practicality sheets. The data collection technique used was non-test with a questionnaire validation of learning devices. The analytical technique used is descriptive statistical analysis. From the results of the study, it was obtained that the average value of RPP validation was 88.73% with a very valid category, while the validation in terms of RPP aspects obtained an average value of 89.24% with a very valid category. The results of the analysis of the average validation of LKPD are 87.5% with a very valid validation level, while the validation in terms of aspects obtained an average value of 87.98% with a very valid category. The average practicality of learning tools obtained a value of 85.4% with very practical category. Based on this study, it was found that the mathematics learning device with the Problem Based Learning model oriented to mathematical problem-solving abilities on the subject matter of the size of concentration and data distribution of class VIII students of SMPN 1 Rengat Barat has been tested for validity and practicality.
The effect of learning Think Talk Write model with Powerpoint assistance on students' mathematics learning outcomes
Authors: Muis Abdul , Priawasana Endra
Published: March 2023

This study aims to know the effect of the Powerpoint-assisted Think Talk Write (TTW) learning model on student learning outcomes. The type of study is experimental and the design is one group pretest-posttest design. This type begins with measuring the initial ability of students than giving treatment and then giving a remeasurement or posttest. This analysis was conducted to determine the effect of the Powerpoint-assisted TTW learning model on students learning outcomes. The results of the study showed that the significance value between the pretest and posttest was 0.002 and the sign value was 0.05. Based on the decision that the sign value is 0.002 and less than 0.05 which means that there is a significant difference between the pretest and posttest there is a significant effect on the treatment given. This means that there is a significant influence on the Powerpoint-assisted TTW learning model on student learning outcomes.
Analysis of Santri's critical thinking with Problem Solving approach
Authors: Trisanti Yuliana , Saleh Hairus , Nuritasari Fetty
Published: March 2023

This study aims to describe the students' thinking ability in solving mathematical problems with Islamic nuances on the subject of the 7th grade set of MTs Darul Ulum Banyuanyar. Before conducting the research, the subject was given learning or knowledge about mathematics with Islamic nuances, more specifically the set material. The technique of taking research subjects is done by using purposive sampling technique. The selected subjects were 3 respondents. In checking the validity of the research using triangulation, the triangulation used is time triangulation. The results of this study indicate that high-ability students can pass all indicators in the indicators of critical thinking, creative and inductive reasoning. Meanwhile, for students with moderate abilities (second and third subjects) in critical thinking, the two subjects go through elementary clarification indicators, not through basic support indicators and determine strategies and tactic. Indicators for drawing conclusions (inference) and further clarification (advances clarification) can be passed, but in the work carried out, it is not done correctly. In creative thinking, students with moderate ability are both through the indicators of fluency and flexibility, and not through indicators of originality and elaboration. Whereas in inductive reasoning the second subject only met two of the 3 indicators of inductive reasoning, namely, fulfilling the indicators of identifying mathematical processes/concepts and their tendencies from the given situation, and compiling estimates relevant to the statement. Meanwhile, in inductive reasoning, the third subject only fulfills one indicator, namely identifying mathematical processes/concepts and their tendencies from the given situation.
Joseon’s Politics in the Midst of Power Rivalry between Meiji Japan and Qing Empire: Focusing on the Perception of War and Politics in Yun Chi-ho Diary
Authors:   Korean Association For Political And Diplomatic History, Park Young-june
Published: March 2023

This paper tries to shed light on the first Sino-Japanese war(1894-1895) from the perspective of hegemonic war. Generally, hegemonic war theories emphasizes differential growth of national power among great powers as one cause of major war. However, some theorists pointed out that foreign policies of middle powers in the midst of great power rivalry can ignite direct confrontation between two powers. Based on this observation, this paper explains what policy did Joseon dynasty take during the power rivalry between Qing Empire and Meiji Japan in the late 19th century. In the face of growing rivalry between Meiji Japan and Qing Empire, politicians in Joseon dynasty began to be divided into pro-Japan faction and pro-Qing faction each other; eventually two factions harshly confronted through Imo military rebellion(壬午軍亂) and Kapsin political upheaval(甲申政變). These internal political clash invited neighboring powers intervention into Joseon’s politics and ignited two powers’ direct confrontation over Korean peninsula’s dominance. Joseon’s younger intellectual Yun Chi- ho’s diary illustrated well how did Joseon’s junior politicians lose the vision of their dynasty’s future and expected advanced foreign countries’ intervention into Joseon’s internal politics.
CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation
Authors: Bai Jian , Fan Fan , Gao Chunchen , Li Shaohua , Li Wei , Wei Tiaoxia , Cheng Shilin , Yu Jinmin , Zheng Chao , Zhao Junlong , Zou Linru , Feng Lei , Yi Jing , Qin Hongyan
Published: March 2023

CD169, a specific marker for macrophages, is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family which acts as an adhesion molecule implicated in cell–cell interaction via sialylated glycoconjugates. Although CD169+ macrophages have been found to participate in erythroblastic island (EBI) formation and support erythropoiesis under homeostasis and stress, the exact role of CD169 and its counter receptor in EBI remains unknown. Herein, we generated CD169-CreERT knock-in mice and investigated the function of CD169 in EBI formation and erythropoiesis using CD169-null mice. EBI formation was impaired in vitro by both blockade of CD169 using anti-CD169 antibody and deletion of CD169 on macrophages. Furthermore, CD43 expressed by early erythroblasts (EB) was identified as the counter receptor for CD169 in mediating the EBI formation via surface plasmon resonance and imaging flow cytometry. Interestingly, CD43 was proven to be a novel indicator of erythroid differentiation due to the progressive decrease of CD43 expression as EB mature. Although CD169-null mice did not display defects in bone marrow (BM) EBI formation in vivo, CD169 deficiency impeded BM erythroid differentiation probably via CD43 under stress erythropoiesis, in concert with the role of CD169 recombinant protein in hemin-induced K562 erythroid differentiation. These findings have shed light on the role of CD169 in EBI under steady and stress erythropoiesis through binding with its counter receptor CD43, suggesting that CD169-CD43 interaction might be a promising therapeutic target for erythroid disorders.
Costo en la implementación de la norma internacional de información financiera de impuesto a las ganancias en las PYMEs
Authors: Paredes Cruz Renato Estuardo , Vasconez Fuentes Jose Luis , Castellano Montiel Alberto Gregorio , Tanqueño Colcha Oscar Paul
Published: March 2023

Introducción: Las Normas Internacionales de Información Financiera fueron concebidas como estándares de general aplicación para todo tipo de empresas; consecuentemente su aplicación inicia con las grandes organizaciones que negociaban en la bolsa de valores, por cuanto se urgía tener información comparable internacionalmente como sustento a la toma de decisiones.  Objetivos: es determinar el costo en la aplicación de la normativa NIIF para PYMEs específicamente de los impuestos diferidos ya que alrededor de 18 países en el mundo han decidido no adoptar esta normativa. Metodología: Se utilizó para el desarrollo de la presente investigación la investigación descriptiva cual permite presentar un punto de vista sobre un tema en particular proporcionando argumentos y evidencias de la revisión bibliográfica realizada. Resultados: Al tratar de implementar la Normativa contable a las PYMEs resulto ser demasiado compleja debido a que estas no contaban con recursos materiales, tecnológicos y humanos suficientes e incluso era debatible el beneficio en la aplicación de ciertas normas. Conclusiones: Hay países que se niegan a implementar las NIFF para PYMES por considerarlas incompletas sin embargo según el paradigma de la utilidad se debería representar en el estado financiera solo información que sirva para la toma de decisiones. Área de estudio: Administración
Las clases online y su relación con el agotamiento emocional en el aprendizaje del inglés
Authors: Cunin Chimborazo Rud Noemi , Díaz Paredes Carmen Genoveva , Paredes Peralta Diana Casandra , Calles Jiménez Romel Francisco
Published: March 2023

Introducción: La educación online ha facilitado la continuidad del proceso de enseñanza – aprendizaje, transfiriendo emergentemente de la modalidad presencial a lo virtual, debido al aparecimiento de la pandemia COVID-19. Objetivo: El propósito del presente estudio fue determinar la incidencia de las clases online y su efecto en el agotamiento emocional del proceso de aprendizaje del idioma inglés. Metodología: La investigación fue descriptiva, con enfoque cuantitativo, de corte transversal y de diseño no experimental. La población objeto de estudio comprendió 103 estudiantes quienes fueron escogidos mediante un muestreo no probabilístico intencional. Se empleó la técnica de la encuesta para medir la aceptación a las clases online; el cuestionario “Escala de Cansancio Emocional” para el agotamiento emocional; y el “Placement Test” para establecer el nivel de inglés. Resultados: Los resultados reflejaron que el 11.7 % independientemente a su género se encontró dentro del rango requerido por el Ministerio de Educación (A2); las mujeres alcanzaron un mejor rendimiento (13,3 %); la destreza que mayor dificultad presentó fue Reading; además el 76,7 % manifestó que los materiales empleados no son didácticos; un 75,7 % expresó su rechazo a dicha modalidad; asimismo, el 60 % indicó que no duermen lo suficiente por causa del estudio; el 83,5 % presentó fatiga y falta de energía; en el análisis de los cruces estadísticos se dedujo que existe una correlación positiva escasa. Conclusiones: Se concluyó que la mayoría de los estudiantes rechazaron el nuevo sistema virtual de educación, identificándose estrés, tensión, fatiga, etc., en los participantes. Área de estudio: Educación.
Evaluation of Extensions of Sinonasal Malignancy by Clinical, Surgical & CT Scan Findings
Authors: Mahady Ascif Al , Zaman Fauzia , Anwar Md Hasnat , Quayum Mohammad Abdul , Atikuzzaman Kazi , Sinha Nanda Kishore
Published: March 2023

Background: Sinonasal malignancies are challenging not only from diagnostic view point but also from therapeutic aspects. Owing to the rarity of the lesions, delayed clinical presentations and poor prognosis there is lack of large experience.
Objectives: Aim of this study is to assess Evaluation of extensions of sinonasal malignancy by correlating clinical and surgical findings with CT scan.
Methods: A Cross Sectional study was carried out in the Department of Otolaryngology-Head and Neck Surgery, Sylhet M.A.G Osmani Medical College Hospital, Sylhet, from August 2019 to July 2021. A total 30 subjects were included in this study based on inclusion and exclusion criteria. A data collection form was designed and prepared including general characteristics of subjects and reviewed clinically, radiologically and surgically. All the data were compiled and sorted properly and the numerical data were analyzed statistically by using Statistical Package for Social Sciences (SPSS-26). The result was expressed as frequency and percentage and displayed with figure and table. Z proportion test, Spearman’s rho correlation coefficient test and Diagnostic accuracy test of clinical, CT and surgical finding were performed as applicable. For all comparisons p value of <0.05 was considered as significant.
Results: In this study, CT findings was positively related with clinical and surgical findings. But this relation was strongly significant with surgical findings. In this study, clinical evaluation was 28.8% Sensitive and 100% Specific. Positive predictive value (PPV) was 100% and negative predictive value (NPV) was 9.1%. CT evaluation was 78.6% Sensitive and 100% Specific. Positive predictive value (PPV) was 100% and negative predictive value (NPV) was 25%. Surgical evaluation was 92.9% sensitive and 100% Specific. Positive predictive value (PPV) was 100% and negative predictive value (NPV) was 50%.
Conclusion: It can be concluded that CT findings was directly correlated with clinical and surgical findings. But this relation was strongly significant with surgical findings.
Bangladesh J Otorhinolaryngol 2022; 28(2): 171-179
IS IT TRANSPARENT AND ACCOUNTABLE, OR JUST STEAL THE PUBLIC ATTENTION?
Authors: Ginting Rafles
Published: March 2023

This study aims to find out how the implementation of transparency carried out by schools related to financial reporting and BOS funds to third parties and to analyse how the accounting system applied to school financial reporting and BOS Funds is compared to the provisions in accordance with Statement of Financial Accounting Standards (ISAK)  35 and technical guidelines related to BOS Funds imposed by the Ministry of Education, Culture, Research, and Technology. In this study, researchers conducted an analysis by collecting data, compiling it. interpret and analyse the data to produce research conclusions. This type of research is descriptive qualitative research through centralized interviews with informants to obtain accurate and relevant data. The results of this study show that the reporting of the school BOS Fund has been carried out, but the financial statements made by the school are still not in accordance with ISAK 35
New Options for Optimal Bronchodilation in Chronic Obstructive Pulmonary Disease
Authors: Charles Caroline
Published: March 2023

The European Respiratory Society (ERS) International Congress was held in Munich, Germany, on 6th– 10th September 2014, and was a particularly important opportunity for leading experts to share recent developments and new clinical evidence for the management of chronic obstructive pulmonary disease (COPD). In recent years, new emerging therapies have allowed patients to benefit from improved clinical outcomes and quality of life, with acceptable toxicities. The 2014 guidelines of the Global Initiative for Chronic Obstructive Lung Disease identified symptom reduction as the main goal of moderate-to- severe COPD management. Combined bronchodilation therapy with different therapeutic classes was recommended as a strategy to ensure improved symptom control while containing adverse events, as opposed to monotherapy. Moreover, combination inhaled bronchodilators that are administered once- daily can improve compliance, compared to twice-daily modalities. This review will summarise newly presented clinical data at ERS 2014, providing further information on the efficacy and safety of such combinations, clinical evidence regarding COPD presentation in various populations, strategies for optimal drug delivery, and safety profile monitoring for recent therapeutic options.
Effectiveness of Inhaler Devices in Adult Asthma and COPD
Authors: Roche Nicolas , Chrystyn Henry , Lavorini Federico , Agusti Alvar , Virchow J. Christian , Dekhuijzen Richard , Price David
Published: March 2023

Inhalation therapy remains the cornerstone of treatment for bronchial diseases. Despite being pharmacologically efficacious, currently available inhaled drugs can have decreased real-life effectiveness due to a variety of factors, including poor inhalation technique. Each device type has its own specifications regarding the optimal way to use it, in terms of device handling and characteristics of the inhalation manoeuvre. Poor inhalation technique is associated with decreased treatment effectiveness. Choosing the optimal device, together with proper education, improves inhalation technique, adherence and outcomes or effectiveness, but has to be performed regularly and rigorously, including visual checking of the patient’s ability to use the inhaler. Some testing devices are also available, as well as various training materials. All healthcare professionals caring for the patient can be involved provided that they have also been properly trained. To optimise treatment effectiveness, healthcare providers should prescribe inhalation device(s) optimised to the patient, accounting for the specific characteristics of each individual, his/her disease, and involved healthcare professionals.
COPD Patients’ Needs and Current Treatment Options
Authors: Viney Jonathan
Published: March 2023

The objective of this meeting was to review the complexities surrounding the management and treatment options for different populations of chronic obstructive pulmonary disease (COPD) patients. Bartolome Celli chaired the symposium and outlined some of the current challenges for COPD management. Donald Tashkin discussed clinical assessment of the newly-diagnosed COPD patient, before moving on to review the initial pharmacotherapy options that are available, specifically the long-acting beta or muscarinic agonists. Claus Vogelmeier presented the options for COPD patients who remain symptomatic despite initial treatment, using data from clinical trials such as SPARK to compare different treatment approaches, and Jadwiga Wedzicha focused on higher-risk patients, presenting pertinent data from studies on patients with increased rates of COPD exacerbation. Finally, Bartolome Celli summarised the meeting and provided his expert insight on classifying COPD patients into phenotypic groups.
Innate Immunity in Systemic Sclerosis – Role of Toll-Like Receptors, Interferon, and the Potential Impact of Vitamin D
Authors: Ionescu Ruxandra , Groseanu Laura
Published: March 2023

Systemic sclerosis (SSc) is an autoimmune disease in which vascular damage and immune activation leads to excessive accumulation of extracellular matrix in the skin and internal organs. Although the focus has been on adaptive immunity in SSc, recent data suggest that innate immunity is critically important. The innate immune system, the first-line barrier against pathogens, modulates mechanisms which activate adaptive immunity. Dysregulation of the innate immune system and toll-like receptors (TLRs) may link immune abnormalities and fibrosis in SSc. TLR signalling pathways might induce production of Type I interferon (IFN) and other cytokines, and represent one of the mechanisms that initiate and develop autoimmunity and subsequent fibrosis. Vitamin D displays many immunomodulatory effects on both innate and adaptive immune responses. Active vitamin D will produce signals via vitamin D receptor and influences TLR stimulation, IFN response, and antimicrobial peptide production. Vitamin D deficiency has been associated with many autoimmune disorders, and can influence clinical phenotype and immune disorders in SSc patients.
Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis
Authors: Herlin Morten , Herlin Troels
Published: March 2023

Juvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as playing a key role in JIA development. This review summarises the present knowledge of human leukocyte antigen (HLA) and non-HLA polymorphisms conferring disease susceptibility, and discusses the areas in JIA genetics, which are still to be investigated in order to apply JIA genetics in a clinical setting.
MANAJEMEN PEMERINTAHAN DALAM INOVASI PELAYANAN PENGADUAN MASYARAKAT DI KABUPATEN KARAWANG (STUDI PADA APLIKASI TANGGAP KARAWANG ATAU TANGKAR)
Authors: Anggrayni Irena
Published: March 2023

Penelitian ini bertujuan untuk mengetahui bagaimana manajemen pemerintahan dalam aplikasi pengaduan masyarakat oleh Pemerintah Kabupaten Karawang berupa pembuatan aplikasi TANGKAR dalam mengorganisasi dan menyelesaikan pengaduan dari masyarakat Karawang. Penelitian ini menggunakan metode penelitian deskriptif kualitatif yang didasarkan pada teori manajemen yang dikemukakan oleh George R Terry yang ditinjau oleh beberapa aspek seperti: perencanaan, pengorganisasian, pelaksanaan, dan pengawasan. Metode yang digunakan adalah menggunakan metode deskriptif dengan pendekatan kualitatif, yang bersifat naratif. Sumber data yang diperoleh yaitu berupa data primer yang berasal dari informan secara langsung dan data sekunder berasal dari data-data pendukung lainnya. Penelitian ini dilakukan dengan cara observasi secara langsung, wawancara yang mendalam kepada narasumber dan instrumen pendukung yang diperkuat dengan adanya dokumentasi, dan didukung oleh data sekunder yang ada. Hasil penelitian menunjukan bahwa manajemen aplikasi ini cukup baik dan aplikasinya cukup bermanfaat dalam menangani berbagai pengaduan yang diberikan dan di bagikan di media sosialnamun ada beberapa hal yang menjadi sebuah evaluasi dan perbaikan bagi aplikasinya yaitu berupa admin yang harus diperbanyak, aplikasi yang butuh perawatan lanjutan agar tidak sering terjadinya error.

Kata Kunci: Manajemen, Pengaduan Masyarakat, TANGKAR
PENERAPAN MODEL INKUIRI MENGGUNAKAN MEDIA BAHAN ALAM UNTUK MENINGKATKAN HASIL BELAJAR SEL VOLTA
Authors: Mutiasari Maya
Published: March 2023

This study aims to determine the improvement of student learning outcomes of class XII sciene semester 2 totaling 32 students by applying the Inquiry model to the voltaic cell material. The research method used is Classroom Action Research which consists of four stages, namely planning, action, observation, and reflection. This classroom action research was conducted in two cycles, the first cycle on the Cell Potential sub-concept, while the second cycle on the Voltaic Cell sub-concept. Data collection techniques were carried out by tests, observation sheets, and student response questionnaires to the learning process. The data analysis technique was qualitatively based on descriptive analysis of the results of the average calculation of the cognitive test results. Before the application of the inquiry model, the students' cognitive average value was 52.81 and after the application of the learning model with the inquiry model it became 67.41 with 44.00% classical completeness in the first cycle, then increased to 81,00 with 81,25% classical completeness in the second cycle. Most of the students' attitudes were positive towards learning with the Inquiry model and students were also more active in the learning process.
Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-based in silico model using single-cell mechanomics
Authors: Boaretti Daniele , Marques Francisco C. , Ledoux Charles , Singh Amit , Kendall Jack J. , Wehrle Esther , Kuhn Gisela A. , Bansod Yogesh D. , Schulte Friederike A. , Müller Ralph
Published: March 2023

Bone remodeling is regulated by the interaction between different cells and tissues across many spatial and temporal scales. Notably, in silico models are regarded as powerful tools to further understand the signaling pathways that regulate this intricate spatial cellular interplay. To this end, we have established a 3D multiscale micro-multiphysics agent-based (micro-MPA) in silico model of trabecular bone remodeling using longitudinal in vivo data from the sixth caudal vertebra (CV6) of PolgA(D257A/D257A) mice, a mouse model of premature aging. Our in silico model includes a variety of cells as single agents and receptor-ligand kinetics, mechanomics, diffusion and decay of cytokines which regulate the cells’ behavior. We highlighted its capabilities by simulating trabecular bone remodeling in the CV6 of five mice over 4 weeks and we evaluated the static and dynamic morphometry of the trabecular bone microarchitecture. Based on the progression of the average trabecular bone volume fraction (BV/TV), we identified a configuration of the model parameters to simulate homeostatic trabecular bone remodeling, here named basal. Crucially, we also produced anabolic, anti-anabolic, catabolic and anti-catabolic responses with an increase or decrease by one standard deviation in the levels of osteoprotegerin (OPG), receptor activator of nuclear factor kB ligand (RANKL), and sclerostin (Scl) produced by the osteocytes. Our results showed that changes in the levels of OPG and RANKL were positively and negatively correlated with the BV/TV values after 4 weeks in comparison to basal levels, respectively. Conversely, changes in Scl levels produced small fluctuations in BV/TV in comparison to the basal state. From these results, Scl was deemed to be the main driver of equilibrium while RANKL and OPG were shown to be involved in changes in bone volume fraction with potential relevance for age-related bone features. Ultimately, this micro-MPA model provides valuable insights into how cells respond to their local mechanical environment and can help to identify critical pathways affected by degenerative conditions and ageing.
Photocrosslinkable natural polymers in tissue engineering
Authors: Moon Seo Hyung , Hwang Hye Jin , Jeon Hye Ryeong , Park Sol Ji , Bae In Sun , Yang Yun Jung
Published: March 2023

Natural polymers have been widely used in scaffolds for tissue engineering due to their superior biocompatibility, biodegradability, and low cytotoxicity compared to synthetic polymers. Despite these advantages, there remain drawbacks such as unsatisfying mechanical properties or low processability, which hinder natural tissue substitution. Several non-covalent or covalent crosslinking methods induced by chemicals, temperatures, pH, or light sources have been suggested to overcome these limitations. Among them, light-assisted crosslinking has been considered as a promising strategy for fabricating microstructures of scaffolds. This is due to the merits of non-invasiveness, relatively high crosslinking efficiency via light penetration, and easily controllable parameters, including light intensity or exposure time. This review focuses on photo-reactive moieties and their reaction mechanisms, which are widely exploited along with natural polymer and its tissue engineering applications.
Multi-performative façade systems: The case of real-time adaptive BIPV shading systems to enhance energy generation potential and visual comfort
Authors: Biloria Nimish , Makki Mohammed , Abdollahzadeh Nastaran
Published: March 2023

Building envelopes invariably tend to be static systems that encounter various performance limitations such as inefficient illuminance admittance, and heat and moisture transmission owing to their non-responsiveness towards environmental fluctuations. In contrast to such façade solutions, responsive façade systems with embedded sensing, actuation, and control systems have been proven to perform with up to 65% higher efficiency by being able to adapt their physical characters, such as orientation, and material property in real-time as a response to fluctuating environmental conditions (visual and thermal) and user preferences. Advancements in artificial intelligence and machine learning processes further aid such responsive façade systems to optimize multiple parameters such as illuminance level and the associated lighting energy, visual discomfort caused by solar glare, solar heat gain, thermal resistance (heating energy and comfort level), and natural ventilation simultaneously. This research investigates the case of a real-time adaptive Building Integrated Photo Voltaic (BIPV) shading system and its ability (in comparison with traditional static building integrated photo voltaic façade systems) to perform as regards visual comfort and energy generation potential simultaneously within the humid subtropical climate of Sydney, Australia. A simulated case scenario wherein a real-time adaptive building integrated photo voltaic shading systems is deployed on a typical multistorey building façade in Sydney, Australia is accordingly presented. The conducted simulation considers the responsive building integrated photo voltaic system as a double-skin façade system and uses multi-objective evolutionary computing principles to decipher its integrability potential. A comparative analysis between traditional static mounted Photo Voltaic (PV) systems as opposed to multi-objective optimization driven real-time adaptive building integrated photo voltaic shading configurations is subsequently presented. The ability to maximize generated energy, while simultaneously maintaining visual comfort is thus a unique proposition of this research.