bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Immune Mechanisms of Resistance to Cediranib in Ovarian Cancer
Authors: Gopinathan Ganga , Berlato Chiara , Lakhani Anissa , Szabova Ludmila , Pegrum Colin , Pedrosa Ana-Rita , Laforets Florian , Maniati Eleni , Balkwill Frances R.
Published: April 2023

Abstract
This article investigates mechanisms of resistance to the VEGF receptor inhibitor cediranib in high-grade serous ovarian cancer (HGSOC), and defines rational combination therapies. We used three different syngeneic orthotopic mouse HGSOC models that replicated the human tumor microenvironment (TME). After 4 to 5 weeks treatment of established tumors, cediranib had antitumor activity with increased tumor T-cell infiltrates and alterations in myeloid cells. However, continued cediranib treatment did not change overall survival or the immune microenvironment in two of the three models. Moreover, treated mice developed additional peritoneal metastases not seen in controls. Cediranib-resistant tumors had intrinsically high levels of IL6 and JAK/STAT signaling and treatment increased endothelial STAT3 activation. Combination of cediranib with a murine anti-IL6 antibody was superior to monotherapy, increasing mouse survival, reducing blood vessel density, and pSTAT3, with increased T-cell infiltrates in both models. In a third HGSOC model, that had lower inherent IL6 JAK/STAT3 signaling in the TME but high programmed cell death protein 1 (PD-1) signaling, long-term cediranib treatment significantly increased overall survival. When the mice eventually relapsed, pSTAT3 was still reduced in the tumors but there were high levels of immune cell PD-1 and Programmed death-ligand 1. Combining cediranib with an anti–PD-1 antibody was superior to monotherapy in this model, increasing T cells and decreasing blood vessel densities. Bioinformatics analysis of two human HGSOC transcriptional datasets revealed distinct clusters of tumors with IL6 and PD-1 pathway expression patterns that replicated the mouse tumors. Combination of anti-IL6 or anti–PD-1 in these patients may increase activity of VEGFR inhibitors and prolong disease-free survival.
Data from Improving Theranostic Gallium-68/Lutetium-177–Labeled PSMA Inhibitors with an Albumin Binder for Prostate Cancer
Authors: Lee Byoung Se , Kim Min Hwan , Chu So Young , Jung Woon Jung , Jeong Hyeon Jin , Lee Kyongkyu , Kim Hyeon Seok , Kim Mi Hyun , Kil Hee Seup , Han Sang Jin , Lee Yong Jin , Lee Kyo Chul , Lim Sang Moo , Chi Dae Yoon
Published: April 2023

Abstract
We developed a novel therapeutic radioligand, [177Lu]1h, with an albumin binding motif and evaluated it in a prostate-specific membrane antigen (PSMA)-expressing tumor xenograft mouse model. Fourteen PSMA target candidates were synthesized, and binding affinity was evaluated with an in vitro competitive binding assay. First, four compound candidates were selected depending on binding affinity results. Next, we selected four compounds ([68Ga]1e, [68Ga]1g, [68Ga]1h, and [68Ga]1k) were screened for tumor targeting efficiency by micro–positron emission tomography/computed tomography (micro-PET/CT) imaging. Finally, [177Lu]1h compound was evaluated the tumor targeting efficiency and therapeutic efficiency by micro–single-photon emission computed tomography/computed tomography (micro-SPECT/CT), biodistribution, and radiotherapy studies. Estimated human effective dose was calculated by biodistribution data. Compound 1h showed a high binding affinity (Ki value = 4.08 ± 0.08 nmol/L), and [177Lu]1h showed extended blood circulation (1 hour = 10.32 ± 0.31, 6 hours = 2.68 ± 1.07%ID/g) compared to [177Lu]PSMA-617 (1 h = 0.17 ± 0.10%ID/g). [177Lu]1h was excreted via the renal pathway and showed high tumor uptake (24.43 ± 3.36%ID/g) after 1 hour, which increased over 72 hours (72 hours = 51.39 ± 9.26%ID/g). Mice treated with 4 and 6 MBq of [177Lu]1h showed a median survival rate of >61 days. In particular, all mice treated with 6 MBq of [177Lu]1h survived for the entire monitoring period. The estimated human effective dose of [177Lu]1h was 0.07 ± 0.01 and 0.03 ± 0.00 mSv/MBq in total body and kidney, respectively. The current study indicates that [177Lu]1h has the potential for further investigation of metastatic castration-resistant prostate cancer (mCRPC) therapy in clinical trials.
Data from Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer
Authors: Khawaja Hajrah , Briggs Rebecca , Latimer Cheryl H. , Rassel Mustasin , Griffin Daryl , Hanson Lyndsey , Bardelli Alberto , Di Nicolantonio Frederica , McDade Simon S. , Scott Christopher J. , Lambe Shauna , Maurya Manisha , Lindner Andreas U. , Prehn Jochen H.M. , Sousa Jose , Winnington Chris , LaBonte Melissa J. , Ross Sarah , Van Schaeybroeck Sandra
Published: April 2023

Abstract
Novel covalent inhibitors of KRASG12C have shown limited response rates in patients with KRASG12C-mutant (MT) colorectal cancer. Thus, novel KRASG12C inhibitor combination strategies that can achieve deep and durable responses are needed. Small-molecule KRASG12C inhibitors AZ’1569 and AZ’8037 were used. To identify novel candidate combination strategies for AZ’1569, we performed RNA sequencing, siRNA, and high-throughput drug screening. Top hits were validated in a panel of KRASG12CMT colorectal cancer cells and in vivo. AZ’1569-resistant colorectal cancer cells were generated and characterized. We found that response to AZ’1569 was heterogeneous across the KRASG12CMT models. AZ’1569 was ineffective at inducing apoptosis when used as a single agent or combined with chemotherapy or agents targeting the EGFR/KRAS/AKT axis. Using a systems biology approach, we identified the antiapoptotic BH3-family member BCL2L1/Bcl-xL as a top hit mediating resistance to AZ’1569. Further analyses identified acute increases in the proapoptotic protein BIM following AZ’1569 treatment. ABT-263 (navitoclax), a pharmacologic Bcl-2 family inhibitor that blocks the ability of Bcl-xL to bind and inhibit BIM, led to dramatic and universal apoptosis when combined with AZ’1569. Furthermore, this combination also resulted in dramatically attenuated tumor growth in KRASG12CMT xenografts. Finally, AZ’1569-resistant cells showed amplification of KRASG12C, EphA2/c-MET activation, increased proinflammatory chemokine profile and cross-resistance to several targeted agents. Importantly, KRAS amplification and AZ’1569 resistance were reversible upon drug withdrawal, arguing strongly for the use of drug holidays in the case of KRAS amplification. Taken together, combinatorial targeting of Bcl-xL and KRASG12C is highly effective, suggesting a novel therapeutic strategy for patients with KRASG12CMT colorectal cancer.
Data from Systemic Checkpoint Blockade by PD-L1 Single-Chain Antibody Confers Potent Antitumor Immunity and Long-term Survival
Authors: Wang Hong , Khattar Vinayak , Hensel Jonathan A. , Ashton Reading , Lu Yun , Sorace Anna G. , Wang Yong , Deshane Jessy S. , Mieher Joshua L. , Deivanayagam Champion , Ponnazhagan Selvarangan
Published: April 2023

Abstract
Immune checkpoint inhibitors (ICI) are promising in adjuvant settings for solid tumors and hematologic malignancies. They are currently used in the treatment as mAbs in high concentrations, raising concerns of toxicity and adverse side effects. Among various checkpoint molecules, targeting the programmed cell death protein-1 (PD-1)–programmed death-ligand 1 (PD-L1) axis has garnered more clinical utility than others have. To develop a physiologically relevant and systemically stable level of ICIs from a one-time application by genetic antibody engineering, we endeavored using a nonpathogenic, replication-deficient recombinant adeno-associated vector (rAAV) expressing single-chain variable fragments (scFv) of PD-L1 antibody and tested in syngeneic mouse therapy models of MC38 colorectal and EMT6 breast tumors. Results of this study indicated a significant protection against PD-L1–mediated inhibition of CD8+ T-cell function, against the growth of primary and secondary tumors, and durable antitumor CTLs activity by adoptive CD8+ T-cell transfer. Stable maintenance of PD-L1 scFv in vivo resulted in an increase in PD-1− CD8+ T cells and a concomitant decrease in regulatory T cells, M2 macrophages, and myeloid-derived suppressor cells in the tumor microenvironment. Overall, these data demonstrate the potential of rAAV-PD-L1-scFv as an alternative to mAb targeting of PD-L1 for tumor therapy.
Supplementary Table S1 from Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer
Authors: Stover Elizabeth H. , Baco Maria B. , Cohen Ofir , Li Yvonne Y. , Christie Elizabeth L. , Bagul Mukta , Goodale Amy , Lee Yenarae , Pantel Sasha , Rees Matthew G. , Wei Guo , Presser Adam G. , Gelbard Maya K. , Zhang Weiqun , Zervantonakis Ioannis K. , Bhola Patrick D. , Ryan Jeremy , Guerriero Jennifer L. , Montero Joan , Liang Felice J. , Cherniack Andrew D. , Piccioni Federica , Matulonis Ursula A. , Bowtell David D.L. , Sarosiek Kristopher A. , Letai Anthony , Garraway Levi A. , Johannessen Cory M. , Meyerson Matthew
Published: April 2023

ORF overexpression screen data
Supplementary Table S2 from A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 Activation
Authors: Yang Zhifen , Zhang Jing , Jiang Dadi , Khatri Purvesh , Solow-Cordero David E. , Toesca Diego A.S. , Koumenis Constantinos , Denko Nicholas C. , Giaccia Amato J. , Le Quynh-Thu , Koong Albert C.
Published: April 2023

Pathway enrichment analysis using Reactome Skypainter.
Supplementary Figure 3 from Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1
Authors: Maher Christina M. , Thomas Jeffrey D. , Haas Derick A. , Longen Charles G. , Oyer Halley M. , Tong Jane Y. , Kim Felix J.
Published: April 2023

Cycloheximide (CHX) pulse-chase.
Supplementary Figure 1 from Circular RNA ciRS-7 Maintains Metastatic Phenotypes as a ceRNA of miR-1299 to Target MMPs
Authors: Sang Meixiang , Meng Lingjiao , Liu Sihua , Ding Pingan , Chang Sheng , Ju Yingchao , Liu Fei , Gu Lina , Lian Yishui , Geng Cuizhi
Published: April 2023

Diagram illustration showing primers, siRNAs and luciferase reporter vectors in the study.
Table S1 from Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast
Authors: Prasad Mayuri , Kumar Brijesh , Bhat-Nakshatri Poornima , Anjanappa Manjushree , Sandusky George , Miller Kathy D. , Storniolo Anna Maria , Nakshatri Harikrishna
Published: April 2023

Description of tissue samples used in the study
Supplemental Figure 1 from Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma
Authors: Hedrick Erik , Mohankumar Kumaravel , Lacey Alexandra , Safe Stephen
Published: April 2023

Supplemental Figure 1
Figure S2 from Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast
Authors: Prasad Mayuri , Kumar Brijesh , Bhat-Nakshatri Poornima , Anjanappa Manjushree , Sandusky George , Miller Kathy D. , Storniolo Anna Maria , Nakshatri Harikrishna
Published: April 2023

Cell surface marker profiles of normal cells grown from BRCA1, BRCA2 and PALB2 mutation carriers
Supplementary Table 6 from BORIS Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through GALNT14
Authors: Hillman Joanna C. , Pugacheva Elena M. , Barger Carter J. , Sribenja Sirinapa , Rosario Spencer , Albahrani Mustafa , Truskinovsky Alexander M. , Stablewski Aimee , Liu Song , Loukinov Dmitri I. , Zentner Gabriel E. , Lobanenkov Victor V. , Karpf Adam R. , Higgins Michael J.
Published: April 2023

New/enhanced CTCF binding sites associated with known genes
Supplementary Data from Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers
Authors: Schweppe Rebecca E. , Pozdeyev Nikita , Pike Laura A. , Korch Christopher , Zhou Qiong , Sams Sharon B. , Sharma Vibha , Pugazhenthi Umarani , Raeburn Christopher , Albuja-Cruz Maria B. , Reigan Philip , LaBarbera Daniel V. , Landa Iñigo , Knauf Jeffrey A. , Fagin James A. , Haugen Bryan R.
Published: April 2023

Summary of CUTC cell line take rates in vivo.
Supplementary Table 2 from BORIS Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through GALNT14
Authors: Hillman Joanna C. , Pugacheva Elena M. , Barger Carter J. , Sribenja Sirinapa , Rosario Spencer , Albahrani Mustafa , Truskinovsky Alexander M. , Stablewski Aimee , Liu Song , Loukinov Dmitri I. , Zentner Gabriel E. , Lobanenkov Victor V. , Karpf Adam R. , Higgins Michael J.
Published: April 2023

Full description of GO categories and genes
Supplementary Figure 1 from A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion
Authors: Ding Zonghui , Roos Alison , Kloss Jean , Dhruv Harshil , Peng Sen , Pirrotte Patrick , Eschbacher Jennifer M. , Tran Nhan L. , Loftus Joseph C.
Published: April 2023

Supplementary Figure 1. EGFR specifically co-immunoprecipitates with TROY, but not Fn14.
Supplemental Figures from Chemokine Signaling Facilitates Early-Stage Breast Cancer Survival and Invasion through Fibroblast-Dependent Mechanisms
Authors: Brummer Gage , Acevedo Diana S. , Hu Qingting , Portsche Mike , Fang Wei Bin , Yao Min , Zinda Brandon , Myers Megan , Alvarez Nehemiah , Fields Patrick , Hong Yan , Behbod Fariba , Cheng Nikki
Published: April 2023

Supplemental Figures S1-S7
Supplementary Figure S1 from TP53 Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer
Authors: Watanabe Sho , Tsuchiya Kiichiro , Nishimura Ryu , Shirasaki Tomoaki , Katsukura Nobuhiro , Hibiya Shuji , Okamoto Ryuichi , Nakamura Tetsuya , Watanabe Mamoru
Published: April 2023

Process of CRISPR-mediated mutagenesis in LS174T cells
Supplementary Table 4 from Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2
Authors: Wang Rui , Liu Hongwei , Shao Yingying , Wang Kailong , Yin Shuangshuang , Qiu Yuling , Wu Honghua , Liu Erwei , Wang Tao , Gao Xiumei , Yu Haiyang
Published: April 2023

Main index of routine blood test of Sophoridine
Figure S7 from Dual Targeting of EGFR and IGF1R in the TNFAIP8 Knockdown Non–Small Cell Lung Cancer Cells
Authors: Day Timothy F. , Kallakury Bhaskar V.S. , Ross Jeffrey S. , Voronel Olga , Vaidya Shantashri , Sheehan Christine E. , Kasid Usha N.
Published: April 2023

IGFBP3 in culture medium
Supplementary Table 2 from Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2
Authors: Wang Rui , Liu Hongwei , Shao Yingying , Wang Kailong , Yin Shuangshuang , Qiu Yuling , Wu Honghua , Liu Erwei , Wang Tao , Gao Xiumei , Yu Haiyang
Published: April 2023

The pharmacokinetic parameters of the main chemical constituents of Radian Sophorae flavescentis
Supplementary Table 1 from Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2
Authors: Wang Rui , Liu Hongwei , Shao Yingying , Wang Kailong , Yin Shuangshuang , Qiu Yuling , Wu Honghua , Liu Erwei , Wang Tao , Gao Xiumei , Yu Haiyang
Published: April 2023

Primers for q-PCR
Supplementary Figure 1 from Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling
Authors: Ringuette Goulet Cassandra , Bernard Geneviève , Tremblay Sarah , Chabaud Stéphane , Bolduc Stéphane , Pouliot Frédéric
Published: April 2023

HF were treated with 1mg/mL of exosomes or TGFÃŸ 4ng/mL. Smad signaling activation was evaluated 1h, 4h or 48h post-treatment by Western blot.
Figure S3 from FLYWCH1, a Novel Suppressor of Nuclear β-Catenin, Regulates Migration and Morphology in Colorectal Cancer
Authors: Muhammad Belal A. , Almozyan Sheema , Babaei-Jadidi Roya , Onyido Emenike K. , Saadeddin Anas , Kashfi Seyed Hossein , Spencer-Dene Bradley , Ilyas Mohammad , Lourdusamy Anbarasu , Behrens Axel , Nateri Abdolrahman S.
Published: April 2023

S3. Expression analyses and transcription activity of FLYWCH1 and Î²-catenin deletions in cells
Supplementary Figures S1-S4 from Influence of Exogenous Tissue Factor on Estrogen Receptorα Expression in Breast Cancer Cells: Involvement of β1-Integrin, PAR2, and Mitogen-Activated Protein Kinase Activation
Authors: Collier Mary E.W. , Li Chao , Ettelaie Camille
Published: April 2023

Supplementary Figures S1-S4 from Influence of Exogenous Tissue Factor on Estrogen Receptorα Expression in Breast Cancer Cells: Involvement of β1-Integrin, PAR2, and Mitogen-Activated Protein Kinase Activation
Supplementary Figure 3 from Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP Model
Authors: Copeland Ben T. , Bowman Matthew J. , Ashman Leonie K.
Published: April 2023

PDF file - 112K, Characterisation for expression of the epithelial cell marker cell marker, E-Cadherin. 5 �m FFPE sections of normal prostate glands from 20 week old TRAMP negative animals along with sections from poorly differentiated primary prostate tumours from TRAMP positive animals were characterised by indirect peroxidase IHC with the anti E-Cadherin antibody (clone 36) that labels epithelial cells, as the primary antibody. The epithelial cells in the normal prostate glands in Panel A stained highly and specifically for E-Cadherin both on the membrane and also through the cytoplasm. In Panel B, the prostate gland that displays PIN has reduced labelling of E-cadherin and the surrounding poorly differentiated prostate tumour tissue was void of specific labelling for E-cadherin
Supplementary Figure 7 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Authors: Javvadi Prashanthi , Makino Haruhiko , Das Amit K. , Lin Yu-Fen , Chen David J. , Chen Benjamin P. , Nirodi Chaitanya S.
Published: April 2023

PDF file - 774K, Proximity ligation assay (PLA): To detect radiation-induced PP2A-DNA-PKcs binding. NSCLCs and HBEC cells expressing WT or gammaE746-E750 EGFR fixed 1 h following 0 Gy or 4 Gy IR. Left panel: representative images of nuclei (blue) and EGFR-DNA-PKcs complexes (red: PLA fluorescence). Square boxes represent cropped images shown in Figure 7C
Supplementary Figure 1 from Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP Model
Authors: Copeland Ben T. , Bowman Matthew J. , Ashman Leonie K.
Published: April 2023

PDF file - 60K, Breeding strategy to produce the experimental animals. To produce the required F1 experimental animals, heterozygous TRAMP C57BL/6 females were crossed with Cd151 KO C57BL/6 males. The resultant Cd151 heterozygous C57BL/6 and TRAMP heterozygous females were then crossed with Cd151 heterozygous FVB/N males. Genetic frequencies shown are specific for the male experimental animals. This breeding program ensured the absence of kidney disease that occurs in FVB/N Cd151 homozygous KO mice. It also ensured a homogeneous genetic background for test and control mice which, in addition, were littermates
Supplementary Figure 5 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Authors: Javvadi Prashanthi , Makino Haruhiko , Das Amit K. , Lin Yu-Fen , Chen David J. , Chen Benjamin P. , Nirodi Chaitanya S.
Published: April 2023

PDF file - 900K, Radiation-induced T2609 phosphorylation in NSCLCs. Immuno-fluorescence detection of DNA-PKcs phosphorylation in indicated NSCLCs showing p-T2609 immunofluorescence (green) in nuclei (blue). Cropped images shown in Figure 6B
Supplementary Table 2 from The Proto-oncogene PKCι Regulates the Alternative Splicing of Bcl-x Pre-mRNA
Authors: Shultz Jacqueline C. , Vu Ngoc , Shultz Michael D. , Mba Mba-Uzoma U. , Shapiro Brian A. , Chalfant Charles E.
Published: April 2023

PDF file - 1.1MB
Supplementary Figures 1-8 from Polycomb-like Protein 3 Induces Proliferation and Drug Resistance in Multiple Myeloma and Is Regulated by miRNA-15a
Authors: Yu Tengteng , Du Chenxing , Ma Xiaoke , Sui Weiwei , Yu Zhen , Liu Lanting , Zhao Lei , Li Zhongqing , Xu Jie , Wei Xiaojing , Zhou Wen , Deng Shuhui , Zou Dehui , An Gang , Tai Yu-Tzu , Tricot Guido , Anderson Kenneth C. , Qiu Lugui , Zhan Fenghuang , Hao Mu
Published: April 2023

Supplementary Fig.1. PHF19 gene expression is associated with poor prognosis in myeloma patients. Supplementary Fig.2. Enhanced PHF19 expression in OCI-My5 cells decrease drug sensitivity. Supplementary Fig.3. PHF19 interacts with EZH2. Supplementary Fig.4. PHF19 promotes EZH2 phosphorylation. Supplementary Fig.5. RNA sequencing indicates that PHF19 activates proliferation-related signaling pathways. Supplementary Fig.6. PHF19 promotes EZH2 phosphorylation via AKT pathway. Supplementary Fig.7. miR-15a can downregulation PHF19 expression. Supplementary Fig.8. Visual Overview
Supplementary Materials and Methods, Figure Legends 1-5, Table 1 from In Situ Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy
Authors: Gajadhar Aaron S. , Bogdanovic Elena , Muñoz Diana Marcela , Guha Abhijit
Published: April 2023

PDF file - 129K
Supplementary Figure 5 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency
Authors: Moser Russell , Toyoshima Masafumi , Robinson Kristin , Gurley Kay E. , Howie Heather L. , Davison Jerry , Morgan Martin , Kemp Christopher J. , Grandori Carla
Published: April 2023

PDF file - 101K
Figure S2 from Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600-Wild-Type Colorectal Cancer
Authors: Georgiou Alexandros , Stewart Adam , Cunningham David , Banerji Udai , Whittaker Steven R.
Published: April 2023

Figure S2. Establishment of conditions for pooled CRISPR screening.
Supplementary Figure 1 from RBM38 Is a Direct Transcriptional Target of E2F1 that Limits E2F1-Induced Proliferation
Authors: Feldstein Orit , Ben-Hamo Rotem , Bashari Dana , Efroni Sol , Ginsberg Doron
Published: April 2023

PDF file - 171K, Activation of ectopic E2F1or endogenous E2F1 silencing regulates RBM38 levels
Supplementary Figure 4 from Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation
Authors: Kawazoe Tetsuro , Saeki Hiroshi , Oki Eiji , Oda Yoshinao , Maehara Yoshihiko , Mori Masaki , Taniguchi Koji
Published: April 2023

The effects of LIF knockdown by shRNAs on the expression of EMT-related transcriptional factors in human ESCC
Supplementary Figures and Tables from A Novel Zebrafish Model of Metastasis Identifies the HSD11β1 Inhibitor Adrenosterone as a Suppressor of Epithelial–Mesenchymal Transition and Metastatic Dissemination
Authors: Nakayama Joji , Lu Jeng-Wei , Makinoshima Hideki , Gong Zhiyuan
Published: April 2023

Figures S1. Liver-specific expression of Twist1a-ERT2 mRNA and increase of mesenchymal marker Vimentin in liver cells in Twist1a-ERT2 transgenic zebrafish. Figure S2. Lack of significant effect of Adrenosterone, Rabeprazole and Olmesartan in primary liver tumor growth, fish survival, liver cell proliferation and apoptosis in Twist1a-ERT2/xmrk double transgenic zebrafish. Figure S3. Effect of Adrenosterone or Rabeprazole on cell viabilities of highly metastatic human cell lines, related to Fig. 4. Figure S4. Expression of mesenchymal markers and appearance E -cad+ cells after adrenosteroneadrenosterone treatment of HCCLM3. Supplementary Table 1. Oligo primers used for cloning, RT-PCR and qPCRPrimer. Supplementary Table S2. The number and frequencies of the fish showing the dissemination patterns in ERT2, Twist1a-ERT2, ERT2/xmrk or Twist1a-ERT2/xmrk double transgenic fish. Supplementary Table S3. Effects of Ki16425 and Y27632 on cell dissemination of Twist1a-ERT2/xmrk double transgenic zebrafish line. Supplementary Table S4. Effects of Adrenosterone, Rabeprazole and Olmesartan on cell dissemination of Twist1a-ERT2/xmrk double transgenic zebrafish line. Supplementary Table S5. Effects of pharmacological and genetic inhibition of HSD11ï�¢1 on metastatic dissemination of human cancer cells in zebrafish xenografted models.
Supplementary Table 4 from Fractalkine Receptor CX3CR1 Is Expressed in Epithelial Ovarian Carcinoma Cells and Required for Motility and Adhesion to Peritoneal Mesothelial Cells
Authors: Kim Mijung , Rooper Lisa , Xie Jia , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

PDF file - 114KB
Supplementary Table 2 from Fractalkine Receptor CX3CR1 Is Expressed in Epithelial Ovarian Carcinoma Cells and Required for Motility and Adhesion to Peritoneal Mesothelial Cells
Authors: Kim Mijung , Rooper Lisa , Xie Jia , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

PDF file - 56KB
Supplementary Tables 1-6 from The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways
Authors: Huang Jianguo , Sachdeva Mohit , Xu Eric , Robinson Timothy J. , Luo Lixia , Ma Yan , Williams Nerissa T. , Lopez Omar , Cervia Lisa D. , Yuan Fan , Qin Xiaodi , Zhang Dadong , Owzar Kouros , Gokgoz Nalan , Seto Andrew , Okada Tomoyo , Singer Samuel , Andrulis Irene L. , Wunder Jay S. , Lazar Alexander J. , Rubin Brian P. , Pipho Krista , Mello Stephano S. , Giudice Jimena , Kirsch David G.
Published: April 2023

Table S1. Primers for real time qPCR. Table S2. p53 mutation status in sarcoma patients. Table S3. The list of lncRNAs that are significantly differentially expressed in lung metastases compared to paired KP primary tumors. Table S4. The list of proteins that interact with only Neat1 sense RNA by RNA pull down asssay combined with mass spectrometry. Table S5. Pathway analysis of RNA sequencing data of paired primary KP sarcomas and lung metastases determined that RNA splicing pathways are significantly downregulated in lung metastases. Table S6. RNA Splicing analysis of RNA sequencing data of paired primary KP sarcomas and lung metastases determined that multiple genes are spliced in different pattern in lung metastases (the lists only contains the genes with |Inclusion level difference (Met vs Pri)| {greater than or equal to} 0.2).
Supplementary Figure Legend from HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells
Authors: Marhold Maximilian , Tomasich Erwin , El-Gazzar Ahmed , Heller Gerwin , Spittler Andreas , Horvat Reinhard , Krainer Michael , Horak Peter
Published: April 2023

Supplementary Figure Legend
Supplementary Tables 1-2, Figures 1-2 from Biological Responses to TGF-β in the Mammary Epithelium Show a Complex Dependency on Smad3 Gene Dosage with Important Implications for Tumor Progression
Authors: Kohn Ethan A. , Yang Yu-an , Du Zhijun , Nagano Yoshiko , Van Schyndle Catherine M.H. , Herrmann Michelle A. , Heldman Madeleine , Chen Jin-Qiu , Stuelten Christina H. , Flanders Kathleen C. , Wakefield Lalage M.
Published: April 2023

PDF file - 249K, Biological responses to TGF-beta in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression Table S1. Primer pair sequences for RTQ-PCR. Table S2. Patient information for matched breast cancer and adjacent normal tissue mRNA used for Smad3 mRNA assessment. FIGURE S1. Effect of Smad3 genotype on TGF-beta -regulated activity of MMPs in IMECs. FIGURE S2. Effect of Smad3 genotype on regulation by TGF-beta of genes involved in EMT and invasion responses
Supplementary Table 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Authors: Parr-Sturgess Catherine A. , Tinker Claire L. , Hart Claire A. , Brown Michael D. , Clarke Noel W. , Parkin Edward T.
Published: April 2023

PDF file - 43K, Summary of catalytically active human ADAM family members tested as candidates for copper-enhanced shedding activity
Supplementary Figure 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Authors: Parr-Sturgess Catherine A. , Tinker Claire L. , Hart Claire A. , Brown Michael D. , Clarke Noel W. , Parkin Edward T.
Published: April 2023

PDF file - 101K, Copper-mediated Jagged1 shedding is accompanied by reciprocal decreases in cell-associated holoprotein only at higher, physiologically irrelevant, metal concentrations
Supplementary Table 4 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Authors: Chiappinelli Katherine B. , Haynes Brian C. , Brent Michael R. , Goodfellow Paul J.
Published: April 2023

PDF file - 106K
Supplementary Table 3 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Authors: Chiappinelli Katherine B. , Haynes Brian C. , Brent Michael R. , Goodfellow Paul J.
Published: April 2023

XLS file - 35K
Supplementary Figure 2 from α-Catulin Marks the Invasion Front of Squamous Cell Carcinoma and Is Important for Tumor Cell Metastasis
Authors: Cao Christine , Chen Yibu , Masood Rizwan , Sinha Uttam K. , Kobielak Agnieszka
Published: April 2023

PDF file - 44K, shRNA lentiviral system was used to generate stable MDA-MB-231 cell lines that were �-catulin-deficient. The specific knockdown of �-catulin in MDA-MB-231 cells (G85) compared to the non-silencing control (GNS) was confirmed by RT-PCR (A), real-time qPCR (A'), and western blot (B). In vitro cell migration (C) and invasion (D) was decreased in �-catulin-ablated MDA-MB-231 cells; cells were visualized with toluidine blue. Standard error bars are shown (n=4 for cell migration and n=4 for invasion assay). *** statistical significance was determined using t-test (p < 0.001) or * analysis of variant (ANOVA) (p <0.02)
Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Authors: Zhan Yang , Zhang Guanyi , Wang Xiaojie , Qi Yanfeng , Bai Shanshan , Li Dongying , Ma Tianfang , Sartor Oliver , Flemington Erik K. , Zhang Haitao , Lee Peng , Dong Yan
Published: April 2023

Primers used for cloning.
Supplementary Figure 9 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

SOX9 controls G0/G1 to S phase cell cycle
Supplementary Figure 6 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Authors: Zhan Yang , Zhang Guanyi , Wang Xiaojie , Qi Yanfeng , Bai Shanshan , Li Dongying , Ma Tianfang , Sartor Oliver , Flemington Erik K. , Zhang Haitao , Lee Peng , Dong Yan
Published: April 2023

S6. AR-V1 does not have inherent transcriptional activity but attenuates AR-V7 transactivation in C4-2 cells.
Supplementary Figure 6 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

SOX9-knockout suppresses TNBC cells xenograft growth in vivo
Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Authors: Zhan Yang , Zhang Guanyi , Wang Xiaojie , Qi Yanfeng , Bai Shanshan , Li Dongying , Ma Tianfang , Sartor Oliver , Flemington Erik K. , Zhang Haitao , Lee Peng , Dong Yan
Published: April 2023

S3. Androgen did not affect AR-V6 transactivation when AR-FL was not present.
Supplementary Figure 2 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

Expression level of SOXs in breast cancer cell lines
Supplementary Table 2 from Human ESC Self-renewal Promoting microRNAs Induce Epithelial–Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways
Authors: Jung Christine J. , Iyengar Sushma , Blahnik Kimberly R. , Jiang Joy X. , Tahimic Candice , Torok Natalie J. , de vere White Ralph W. , Farnham Peggy J. , Zern Mark
Published: April 2023

XLS file - 34K, KEGG Pathway Categories of Genes Highly Enriched in hESCs, HCCs and hPHs
Supplementary Figures 1-6 from Human ESC Self-renewal Promoting microRNAs Induce Epithelial–Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways
Authors: Jung Christine J. , Iyengar Sushma , Blahnik Kimberly R. , Jiang Joy X. , Tahimic Candice , Torok Natalie J. , de vere White Ralph W. , Farnham Peggy J. , Zern Mark
Published: April 2023

PDF file - 1.3MB, S1. Pearson correlation analysis of hESCs, HCCs and hPHS. S2. EHCC miRNAs are not capable of rescuing hepatic progenitor cell induction in Dgcr8 null mESCs during the in vitro differentiation process of mESCs along a hepatic lineage. S3. EHCC miRNAs cannot rescue the deficiency in hepatocyte differentiation in Dgcr8 null mESCs. S4. Experimental timeline of hPHs. S5. Global gene expression analysis between hPHs and hPHs expressing EHCC miRNAs. S6. Expression patterns of genes reported to be associated with HCCs, ESCs and hepatic progenitor stem cells following EHCC miRNA overexpression in hPHs
Legends for supplemental Figure 1 and 2 from The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer
Authors: Luo Leo Y. , Kim Eejung , Cheung Hiu Wing , Weir Barbara A. , Dunn Gavin P. , Shen Rhine R. , Hahn William C.
Published: April 2023

Legends for supplemental Figure 1 and 2
Video from SRSF2 Regulation of MDM2 Reveals Splicing as a Therapeutic Vulnerability of the p53 Pathway
Authors: Comiskey Daniel F. , Montes Matías , Khurshid Safiya , Singh Ravi K. , Chandler Dawn S.
Published: April 2023

3D rendering of 60X confocal images taken of SRSF2 (green) and SRRM2 (red) coimmunofluorescence in HeLa S3 cells after 12 hours of UVC treatment. Colocalization channel is indicated by magenta color, while the blue color represents the nucleus stained with DAPI.
Supplementary Table 1 from MnSOD Promotes Tumor Invasion via Upregulation of FoxM1–MMP2 Axis and Related with Poor Survival and Relapse in Lung Adenocarcinomas
Authors: Chen Po-Ming , Wu Tzu-Chin , Shieh Shwn-Huey , Wu Yi-Hui , Li Min-Chin , Sheu Gwo-Tarng , Cheng Ya-Wen , Chen Chih-Yi , Lee Huei
Published: April 2023

Supplementary Table 1 PDF file - 142K, Relationship of MnSOD IHC, FoxM1, MMP2 and MnSOD mRNA expression with clinical parameters in lung adenocarcinoma patients
Figure S3 from Dual Inhibition of CDK4 and CDK2 via Targeting p27 Tyrosine Phosphorylation Induces a Potent and Durable Response in Breast Cancer Cells
Authors: Patel Priyank , Tsiperson Vladislav , Gottesman Susan R.S. , Somma Jonathan , Blain Stacy W.
Published: April 2023

Fig. S3 shows the viability plots for MDA MB231 cells treated with different concentrations of PD.
Supplementary Figure S4 from miR-629 Targets TRIM33 to Promote TGFβ/Smad Signaling and Metastatic Phenotypes in ccRCC
Authors: Jingushi Kentaro , Ueda Yuko , Kitae Kaori , Hase Hiroaki , Egawa Hiroshi , Ohshio Ikumi , Kawakami Ryoji , Kashiwagi Yuri , Tsukada Yohei , Kobayashi Takumi , Nakata Wataru , Fujita Kazutoshi , Uemura Motohide , Nonomura Norio , Tsujikawa Kazutake
Published: April 2023

Supplementary Figure S4. A, ACHN cells were transfected with TRIM33 siRNA or control siRNA for 24 h and then stimulated with or without TGF-β1 for 48 h. A wound was then formed by scraping and was measured after 24 h. The results are means {plus minus} S.D. of four independent experiments. *p < 0.05 vs. control siRNA without TGF-β1. White bars indicate 200 μm. B, ACHN cells were transfected with TRIM33 siRNA or control siRNA for 24 h and then stimulated with or without TGF-β1 for 48 h. A cell suspension was added to the upper chamber of matrigel-coated transwell membrane inserts; the lower chamber was filled with the medium and cultured for 12 h. Invasive cells were stained and fluorescence was measured. Values are means {plus minus} S.D. of three independent experiments.
Supplementary Figure S1 from miR-629 Targets TRIM33 to Promote TGFβ/Smad Signaling and Metastatic Phenotypes in ccRCC
Authors: Jingushi Kentaro , Ueda Yuko , Kitae Kaori , Hase Hiroaki , Egawa Hiroshi , Ohshio Ikumi , Kawakami Ryoji , Kashiwagi Yuri , Tsukada Yohei , Kobayashi Takumi , Nakata Wataru , Fujita Kazutoshi , Uemura Motohide , Nonomura Norio , Tsujikawa Kazutake
Published: April 2023

Supplementary Figure S1. A, ACHN cells were transfected with miR-629 mimic or negative control mimic for 72 h. TRIM33 mRNA levels were examined by quantitative real-time PCR. Data are the relative expression normalized to GAPDH mRNA. Values are means {plus minus} S.D. of 3 independent experiments. **p < 0.01 vs. control mimic. B, The expression of miR-629 and TRIM33 mRNAs expression (fold-change: tumor vs. normal) were examined in 41 matched-pair samples of ccRCC by quantitative real-time PCR, and the relationship was evaluated.
Supplementary Figure 2 from Heparin-like Polysaccharides Reduce Osteolytic Bone Destruction and Tumor Growth in a Mouse Model of Breast Cancer Bone Metastasis
Authors: Pollari Sirkku , Käkönen Rami S. , Mohammad Khalid S. , Rissanen Jukka P. , Halleen Jussi M. , Wärri Anni , Nissinen Liisa , Pihlavisto Marjo , Marjamäki Anne , Perälä Merja , Guise Theresa A. , Kallioniemi Olli , Käkönen Sanna-Maria
Published: April 2023

PDF file - 28K, Supplementary Figure 2. A, the effects of the six most potent siRNA screen hits on IL-11 secretion in MDA-MB-231(SA) cells (n=3). B, the effects of heparan sulfate modifying enzymes on IL-11 secretion in MDA-MB-231(SA) cells (n=4). *, P < 0.05; **, P <0.01; ***, P <0.001 (t test).
Supplementary Figure 1 from A New Phage-Display Tumor-Homing Peptide Fused to Antiangiogenic Peptide Generates a Novel Bioactive Molecule with Antimelanoma Activity
Authors: Matsuo Alisson L. , Juliano Maria A. , Figueiredo Carlos R. , Batista Wagner L. , Tanaka Aparecida S. , Travassos Luiz R.
Published: April 2023

PDF file - 289K
Supplementary Table S1 from Exon-Level Microarray Analyses Identify Alternative Splicing Programs in Breast Cancer
Authors: Lapuk Anna , Marr Henry , Jakkula Lakshmi , Pedro Helder , Bhattacharya Sanchita , Purdom Elizabeth , Hu Zhi , Simpson Ken , Pachter Lior , Durinck Steffen , Wang Nicholas , Parvin Bahram , Fontenay Gerald , Speed Terence , Garbe James , Stampfer Martha , Bayandorian Hovig , Dorton Shannon , Clark Tyson A. , Schweitzer Anthony , Wyrobek Andrew , Feiler Heidi , Spellman Paul , Conboy John , Gray Joe W.
Published: April 2023

Supplementary Table S1.
Supplementary Figure 1 from Quiescin Sulfhydryl Oxidase 1 Promotes Invasion of Pancreatic Tumor Cells Mediated by Matrix Metalloproteinases
Authors: Katchman Benjamin A. , Antwi Kwasi , Hostetter Galen , Demeure Michael J. , Watanabe Aprill , Decker G. Anton , Miller Laurence J. , Von Hoff Daniel D. , Lake Douglas F.
Published: April 2023

PDF file - 187K, Tyrpan Blue Assay.
Supplementary Data from Oncogenic Ras Signals through Activation of Both Phosphoinositide 3-Kinase and Rac1 to Induce c-Jun NH2-Terminal Kinase–Mediated, Caspase-Independent Cell Death
Authors: Byun Joo-Yun , Kim Min-Jung , Yoon Chang-Hwan , Cha Hyukjin , Yoon Gyesoon , Lee Su-Jae
Published: April 2023

Supplementary Data from Oncogenic Ras Signals through Activation of Both Phosphoinositide 3-Kinase and Rac1 to Induce c-Jun NH2-Terminal Kinase–Mediated, Caspase-Independent Cell Death
Supplementary Figure S1 from Gain-of-Function Mutations in the Extracellular Domain of KIT Are Common in Canine Mast Cell Tumors
Authors: Letard Sébastien , Yang Ying , Hanssens Katia , Palmérini Fabienne , Leventhal Phillip S. , Guéry Stéphanie , Moussy Alain , Kinet Jean-Pierre , Hermine Olivier , Dubreuil Patrice
Published: April 2023

Supplementary Figure S1 from Gain-of-Function Mutations in the Extracellular Domain of KIT Are Common in Canine Mast Cell Tumors
Supplementary Data from Bioenergetic Metabolites Regulate Base Excision Repair–Dependent Cell Death in Response to DNA Damage
Authors: Tang Jiang-bo , Goellner Eva M. , Wang Xiao-hong , Trivedi Ram N. , St Croix Claudette M. , Jelezcova Elena , Svilar David , Brown Ashley R. , Sobol Robert W.
Published: April 2023

Supplementary Data from Bioenergetic Metabolites Regulate Base Excision Repair–Dependent Cell Death in Response to DNA Damage
Supplementary Data from A Novel Inhibitor of DNA Polymerase β Enhances the Ability of Temozolomide to Impair the Growth of Colon Cancer Cells
Authors: Jaiswal Aruna S. , Banerjee Sanjeev , Panda Harekrushna , Bulkin Charles D. , Izumi Tadahide , Sarkar Fazlul H. , Ostrov David A. , Narayan Satya
Published: April 2023

Supplementary Data from A Novel Inhibitor of DNA Polymerase β Enhances the Ability of Temozolomide to Impair the Growth of Colon Cancer Cells
Supplementary Legends for Figure 1 and Tables 1-2 from NFBD1/MDC1 Regulates Cav1 and Cav2 Independently of DNA Damage and p53
Authors: Wilson Kathleen A. , Colavito Sierra A. , Schulz Vincent , Wakefield Patricia Heffernan , Sessa William , Tuck David , Stern David F.
Published: April 2023

Supplementary Legends for Figure 1 and Tables 1-2 from NFBD1/MDC1 Regulates Cav1 and Cav2 Independently of DNA Damage and p53
Supplementary Methods, Figures 1-5, Tables 1-2 from Autocrine Endothelin-3/Endothelin Receptor B Signaling Maintains Cellular and Molecular Properties of Glioblastoma Stem Cells
Authors: Liu Yue , Ye Fei , Yamada Kazunari , Tso Jonathan L. , Zhang Yibei , Nguyen David H. , Dong Qinghua , Soto Horacio , Choe Jinny , Dembo Anna , Wheeler Hayley , Eskin Ascia , Schmid Ingrid , Yong William H. , Mischel Paul S. , Cloughesy Timothy F. , Kornblum Harley I. , Nelson Stanley F. , Liau Linda M. , Tso Cho-Lea
Published: April 2023

PDF file - 518K
Supplementary Data from Interleukin-1R–Associated Kinase 2 Is a Novel Modulator of the Transforming Growth Factor β Signaling Cascade
Authors: Mullenders Jasper , Fabius Armida W.M. , van Dongen Miranda M.W. , Kuiken Hendrik J. , Beijersbergen Roderick L. , Bernards René
Published: April 2023

Supplementary Data from Interleukin-1R–Associated Kinase 2 Is a Novel Modulator of the Transforming Growth Factor β Signaling Cascade
Supplementary Figure 5 from Suppression of Autophagy by FIP200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents
Authors: Bae Heekyong , Guan Jun-Lin
Published: April 2023

PDF file - 97K
Supplementary Figure 4 from Suppression of Autophagy by FIP200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents
Authors: Bae Heekyong , Guan Jun-Lin
Published: April 2023

PDF file - 46K
Supplementary Data from Cadherin-Cadherin Engagement Promotes Cell Survival via Rac1/Cdc42 and Signal Transducer and Activator of Transcription-3
Authors: Arulanandam Rozanne , Vultur Adina , Cao Jun , Carefoot Esther , Elliott Bruce E. , Truesdell Peter F. , Larue Lionel , Feracci Hélène , Raptis Leda
Published: April 2023

Supplementary Data from Cadherin-Cadherin Engagement Promotes Cell Survival via Rac1/Cdc42 and Signal Transducer and Activator of Transcription-3
Supplementary Figure 3 from Suppression of Autophagy by FIP200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents
Authors: Bae Heekyong , Guan Jun-Lin
Published: April 2023

PDF file - 38K
Supplementary Figure 1 from Suppression of Autophagy by FIP200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents
Authors: Bae Heekyong , Guan Jun-Lin
Published: April 2023

PDF file - 145K
Supplementary Data from Autophagy Regulates Keratin 8 Homeostasis in Mammary Epithelial Cells and in Breast Tumors
Authors: Kongara Sameera , Kravchuk Olga , Teplova Irina , Lozy Fred , Schulte Jennifer , Moore Dirk , Barnard Nicola , Neumann Carola A. , White Eileen , Karantza Vassiliki
Published: April 2023

Supplementary Figures S1-S2; Supplementary Materials and Methods; Supplementary Table S1.
Supplementary Figures S1-S5 from Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway
Authors: Liu Shu-Guang , Wang Bo-Shi , Jiang Yan-Yi , Zhang Tong-Tong , Shi Zhi-Zhou , Yang Yang , Yang Yi-Ling , Wang Xiao-Chun , Lin De-Chen , Zhang Yu , Yang Hai , Cai Yan , Zhan Qi-Min , Wang Ming-Rong
Published: April 2023

Supplementary Figures S1-S5.
Supplementary Figure 1 from Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy
Authors: Roongta Urvashi V. , Pabalan Jonathan G. , Wang Xinyu , Ryseck Rolf-Peter , Fargnoli Joseph , Henley Benjamin J. , Yang Wen-Pin , Zhu Jun , Madireddi Malavi T. , Lawrence R. Michael , Wong Tai W. , Rupnow Brent A.
Published: April 2023

PDF file - 70K
Supplementary Figure 2 from Epithelial Protein-Tyrosine Phosphatase 1B Contributes to the Induction of Mammary Tumors by HER2/Neu but Is Not Essential for Tumor Maintenance
Authors: Balavenkatraman Kamal K. , Aceto Nicola , Britschgi Adrian , Mueller Urs , Bence Kendra K. , Neel Benjamin G. , Bentires-Alj Mohamed
Published: April 2023

PDF File (553K)
Supplementary Figure S1 from Yin Yang 1 Regulates the Expression of Snail through a Distal Enhancer
Authors: Palmer Matthew B. , Majumder Parimal , Cooper John C. , Yoon Hyesuk , Wade Paul A. , Boss Jeremy M.
Published: April 2023

Supplementary Figure S1 from Yin Yang 1 Regulates the Expression of Snail through a Distal Enhancer
Supplementary Data from Dysregulation of Platelet-Derived Growth Factor β-Receptor Expression by ΔNp73 in Neuroblastoma
Authors: Wetterskog Daniel , Moshiri Abtin , Ozaki Toshinori , Uramoto Hidetaka , Nakagawara Akira , Funa Keiko
Published: April 2023

Supplementary Data from Dysregulation of Platelet-Derived Growth Factor β-Receptor Expression by ΔNp73 in Neuroblastoma
Supplementary Data from Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis
Authors: Boisvert-Adamo Karen , Longmate Whitney , Abel Ethan V. , Aplin Andrew E.
Published: April 2023

Supplementary Data from Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis
Supplementary Data from The Tumor Suppressor Maspin Mediates E2F1-Induced Sensitivity of Cancer Cells to Chemotherapy
Authors: Ben Shachar Berta , Feldstein Orit , Hacohen Dalia , Ginsberg Doron
Published: April 2023

Supplementary Data from The Tumor Suppressor Maspin Mediates E2F1-Induced Sensitivity of Cancer Cells to Chemotherapy
Supplementary Figures 1-9 from MicroRNA-138 Modulates DNA Damage Response by Repressing Histone H2AX Expression
Authors: Wang Yemin , Huang Jen-Wei , Li Ming , Cavenee Webster K. , Mitchell Patrick S. , Zhou Xiaofeng , Tewari Muneesh , Furnari Frank B. , Taniguchi Toshiyasu
Published: April 2023

PDF file - 1581K
Supplementary Data from Cyclooxygenase-2 Up-Regulates Ataxia Telangiectasia and Rad3 Related through Extracellular Signal-Regulated Kinase Activation
Authors: Kim Young Mee , Lee Eun Jung , Park Soo-Yeon , Cho Kwan Ho , Kim Joo Young , Pyo Hongryull
Published: April 2023

Supplementary Data from Cyclooxygenase-2 Up-Regulates Ataxia Telangiectasia and Rad3 Related through Extracellular Signal-Regulated Kinase Activation
Supplementary Data from Functional Analysis of Secreted Caveolin-1 in Mouse Models of Prostate Cancer Progression
Authors: Watanabe Masami , Yang Guang , Cao Guangwen , Tahir Salahaldin A. , Naruishi Koji , Tabata Ken-ichi , Fattah Elmoataz Abdel , Rajagopalan Kartik , Timme Terry L. , Park Sanghee , Kurosaka Shinji , Edamura Kohei , Tanimoto Ryuta , Demayo Francesco J. , Goltsov Alexei A. , Thompson Timothy C.
Published: April 2023

Supplementary Data from Functional Analysis of Secreted Caveolin-1 in Mouse Models of Prostate Cancer Progression