bluuebunny/crossref_metadata_2025 huggingface dataset:
The Safety of Propofol Versus Sevoflurane for General Anesthesia in Children: A Meta-Analysis of Randomized Controlled Trials
Authors: Zhao Ying , Qin Feng , Liu Yuhang , Dai Yanping , Cen Xiaobo
Published: June 2022

Background

Propofol and sevoflurane are the most used anesthetics for pediatric surgery. Emergence agitation, postoperative nausea and vomiting and postoperative pain are the primary adverse effect of these general anesthetics. Many clinical studies had compared the safety of propofol and sevoflurane in pediatric surgery, but the results were controversial.

Objectives

To evaluate the evidence surrounding the safety of propofol versus sevoflurane for general anesthesia in children.

Methods

Databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Data and Vip Data were searched to collect relevant articles. Trials were strictly selected according to previously defined inclusion and exclusion criteria. RevMan 5.3 software was used for meta-analyses.

Results

Twenty randomized controlled trials recruiting 1,550 children for general anesthesia were included, with overall low-moderate methodological quality. There was evidence that compared with sevoflurane anesthesia, propofol anesthesia significantly decreased the incidence of emergence agitation (OR = 4.99, 95% CI, 3.67–6.80; P < 0.00001), postoperative nausea and vomiting (OR = 1.91, 95% CI, 1.27–2.87; P  =  0.002) and postoperative pain (OR = 1.72, 95% CI, 1.11–2.64; P = 0.01) in children. However, patients who received sevoflurane tended to have shorter times to eye opening (MD = −2.58, 95% CI, −2.97– −2.19; P < 0.00001) and times to extubation (MD = −1.42, 95% CI, −1.81– −1.02; P < 0.00001).

Conclusions

This review reveals that the children who received propofol anesthesia had the lower risks of emergence agitation, postoperative nausea and vomiting and postoperative pain when compared with sevoflurane anesthesia. But the children who received sevoflurane recovered slightly faster than those received propofol. Considering the limitations of the included studies, better methodological quality and large controlled trials are expected to further quantify the safety of propofol and sevoflurane for general anesthesia in children.
Prevalence and Molecular Characterization of Toxoplasma gondii and Toxocara cati Among Stray and Household Cats and Cat Owners in Tehran, Iran
Authors: Karimi Poorya , Shafaghi-Sisi Soheila , Meamar Ahmad Reza , Nasiri Gelareh , Razmjou Elham
Published: June 2022

Toxoplasma gondii and Toxocara spp. are the most critical parasites common between humans and cats. The close association of cats with humans in urban areas persuaded us to investigate the prevalence of these parasites in stray and household cats and their possible role in the owners' infection. Herein, 132 and 33 fecal samples of stray and household cats, respectively, and 33 blood samples of their owners were collected in Tehran, Iran. The prevalence of T. gondii was determined by targeting the B1 gene in the feces of stray and household cats and the blood of cat owners. Furthermore, genotypes of T. gondii were identified based on the multilocus genotyping of BTUB, GRA6, SAG3, and APICO loci. Toxocara spp. were detected by targeting the second internal transcribed spacer (ITS-2) of the ribosomal DNA of these parasites in the cats' feces and the humans' blood. Also, Toxocara IgG was assessed in the human serum samples. The B1 gene amplification showed that 15.2% of stray cats, 18.2% of household cats, and 51.5% of cat owners were infected with T. gondii. The multilocus sequence analysis revealed the predominance of genotype I of T. gondii in stray cats and genotype II of T. gondii in household cats and cat owners. The amplifying of ITS-2 revealed a high prevalence of T. cati infection (47.0%) in stray cats, whereas no infection was found in the feces of household cats or the serum of cat owners. Likewise, Toxocara IgG was not detected in the serum of humans. The lower prevalence of T. gondii in stray/household cats than in the cat owners indicates the limited impact of close contact with infected cats in human toxoplasmosis. However, the high prevalence of T. cati infection in stray cats can cause contamination of the environment by excreting eggs that may lead to infecting humans through soil or water. Therefore, public health education in urban management planning is necessary for routine urban cat deworming programs and for training the healthcare workers to prevent, control, and treat these infections.
The Open Cryotop System Is Effective for the Simultaneous Vitrification of a Large Number of Porcine Embryos at Different Developmental Stages
Authors: Gonzalez-Plaza Alejandro , Cambra Josep M. , Parrilla Inmaculada , Gil Maria A. , Martinez Emilio A. , Martinez Cristina A. , Cuello Cristina
Published: June 2022

The Superfine Open Pulled Straw (SOPS) system is the most commonly used method for vitrification of pig embryos. However, this system only allows the vitrification of four to seven embryos per straw. In this study, we investigated the effectiveness of the open (OC) and closed (CC) Cryotop® systems to simultaneously vitrify a larger number of porcine embryos. Morulae, early blastocysts and full blastocysts were vitrified with the open Cryotop® (n = 250; 20 embryos per device) system, the closed Cryotop® (n = 158; 20 embryos per device) system and the traditional superfine open pulled straw (SOPS; n = 241; 4–7 embryos per straw) method. Fresh embryos from each developmental stage constituted the control group (n = 132). Data expressed as percentages were compared with the Fisher's exact test. The Kruskal-Wallis test was used to analyze the effect of the different vitrification systems on the embryo quality parameters and two-by-two comparisons were accomplished with the Mann-Whitney U test. Differences were considered statistically significant when p < 0.05. Vitrified and control embryos were incubated for 24 h and examined for viability and quality. At the warming step, the embryo recovery rate for the CC system was 51%, while all embryos were recovered when using OC and SOPS. There were no differences between the vitrification and control groups in the postwarming viability of full blastocysts. In contrast, morulae and early blastocysts that were vitrified-warmed with the SOPS system had lower viability (p < 0.01) compared to those from the OC, CC and control groups. The embryonic viability was similar between the OC and control groups, regardless of the developmental stage considered. Moreover, the embryos from the OC group had comparable total cell number and cells from the inner cell mass and apoptotic index than the controls. In conclusion, the OC system is suitable for the simultaneous vitrification of 20 porcine embryos at different developmental stages and provides comparable viability and quality results to fresh embryos subjected to 24 h of in vitro culture.
A Basic Study on Hybrid Systems for Small Race Car to Improve Dynamic Performance Using Lap Time Simulation
Authors: Kobayashi Ikkei , Ogawa Kazuki , Uchino Daigo , Ikeda Keigo , Kato Taro , Endo Ayato , Bin Peeie Mohamad Heerwan , Narita Takayoshi , Kato Hideaki
Published: June 2022

A hybrid vehicle is a vehicle with two or more power sources. We propose a hybrid system in which the engine torque converted by the transmission is combined with an electric motor torque. The proposed system reduces transmission because engine torque only acts during transmission. Furthermore, the proposed hybrid system’s simple structure uses lightweight chains and sprockets that can be laid out in various ways. The realization of the proposed hybrid system requires independent control algorithms for the two power systems, engine and electric motor, that take into consideration the state of the vehicle and the driver’s input; this system can be assumed to be a servo model system with multiple inputs and outputs and analyzed to obtain the optimal operation algorithm. To apply these controls to race cars, which are required to be fast, it is necessary to obtain the reference input, which is the optimal velocity and yaw angle while traveling the course of the servo system, and simulations of the competition track must be carried out. Therefore, the dynamic performance of the hybrid system was investigated by calculating the lap times on a given circuit using a quasi-steady-state method with low computational load and high prediction accuracy. In this study, the effects of changing the electric motor and final gear ratios on the driving performance of a rear-wheel-drive parallel hybrid system for optimization were investigated. The simulation results show that not only can the optimum settings be obtained by changing the final and electric motor reduction ratios on the evaluation circuit, but also that the optimum values vary across different speed ranges on different circuits.
The Effects of Ecological Public Welfare Jobs on the Usage of Clean Energy by Farmers: Evidence from Tibet Areas—China
Authors: Zhang Huaquan , Tang Yashuang , Ankrah Twumasi Martinson , Chandio Abbas Ali , Guo Lili , Wan Ruixin , Pan Shilei , Shen Yun , Sargani Ghulam Raza
Published: June 2022

In several rural areas of China, ecological public welfare work is an effective way to improve farmers’ social participation. This job does not only increase farmers’ income but also greatly improves their enthusiasm for ecological environment protection. Under the goal of carbon neutrality in peak carbon dioxide (CO2) emissions, it is necessary to explore the impact of ecological public welfare jobs on the usage of Clean Energy (CE) in rural areas. Based on the data of 1100 farmers from Tibet areas in China, this paper applied the Ordered Probit model to explore the impact of ecological public welfare jobs on farmers’ use of CE. The results are as follows: (1) Holding ecological public welfare jobs can raise farmers’ willingness to use CE; (2) Holding ecological public welfare jobs can also promote farmers’ use of CE by enhancing their ecological environment cognition and influencing their social behavior; (3) The impact of ecological public welfare work on CE use has regional and income heterogeneities. Firstly, this effect is smaller in mixed pastoral-farming areas than in agricultural and pastoral areas. Secondly, this effect is more obvious in low-income groups. Our study provided several policies aimed at improving rural and environmental development.
Can Agricultural Machinery Harvesting Services Reduce Cropland Abandonment? Evidence from Rural China
Authors: Xue Ping , Han Xinru , Wang Yongchun , Wang Xiudong
Published: June 2022

Ending hunger, achieving food security, and promoting sustainable agriculture are the main targets of sustainable development goals. It is well known that cropland resources are the most essential factor in achieving sustainable development goals. However, China has been facing the problem of a continuous reduction in cropland resources. Reducing the abandonment of cropland has become an important way to curb the reduction in cropland resources. Can agricultural machinery harvesting services reduce cropland abandonment in rural China? To answer this scientific question, this study employs the Survey for Agriculture and Village Economy data from 8345 samples of 12 provinces in rural China. The extended regression models (i.e., the extended probit regression model and the extended interval regression model) are used to empirically analyze the relationship between agricultural machinery harvesting services accessed by farmers and cropland abandonment. The results are as follows. Agricultural machinery harvesting services accessed by farmers significantly reduced the probability of cropland abandonment and the proportion of the area of abandoned cropland in farmers’ contracted cropland area decreased by 18.5% and 20.3%, respectively. Moreover, the heterogeneity analysis results showed that farmers’ access to agricultural machinery harvesting services significantly reduced cropland abandonment in small-scale groups, without elderly households, with nonagricultural income groups, and in the eastern region. This study also provides some policy implications for policymakers to reduce cropland abandonment in rural China.
A Comparison of Water Imbibition and Controlled Deterioration in Five Orthodox Species
Authors: Fatokun Kayode , Beckett Richard Peter , Varghese Boby
Published: June 2022

Orthodox seeds deteriorate even when stored in the best of conditions; hence, it is very important to monitor germination in stored seeds. To assess orthodox seed deterioration, a germination test is usually employed. This study assessed and compared seed deterioration in five orthodox species using electrolyte leakage and Fourier transform infrared spectroscopy (FTIR). The study also compared water imbibition by the test orthodox seeds. To achieve this, the seeds from three wild (Bolusanthus speciosus; Combretum erythrophyllum; Erythrina caffra) and two agricultural (Pisum sativum and Cucurbita pepo) species were imbibed between 20 layers of single-ply paper towel. The other set was subjected to controlled deterioration at 40 °C and 100% relative humidity for 32 d, with samples taken for germination and electrolyte leakage measurement at 4 d intervals. FTIR measurements were performed at 0, 20, and 32 d of controlled deterioration. The results indicated that there were some significant interspecies differences in the imbibition times and seed water contents but these were not large. In all species, uptake of water was complete between about 15 and 25 h. The wild species showed higher sensitivity to controlled deterioration. Complete loss of germinability occurred much earlier in the wild species (20 d in B. speciosus and E. caffra, and 16 d in Co. erythrophyllum) compared with 36 d for the agricultural species P. sativum and Cu. pepo. There was a negative correlation between electrolyte leakage and seed germination in all wild and agricultural species. A strong positive correlation was observed between the time of controlled deterioration, electrolyte leakage, and FTIR transmission in all the species. While controlled deterioration may help in decisions relating to the storage of orthodox seeds, the water imbibition results from this study will help to set the priming time of the species. The study reaffirms electrolyte leakage as an indicator of seed viability in P. sativum and Cu. pepo; it also recommends the use of electrolyte leakage as an indicator of seed deterioration in B. speciosus, Co. erythrophyllum, and E. caffra. The study also recommends FTIR as a tool for monitoring the germination of stored seeds of all the test species.
Phylogenetic Implication of Large Intergenic Spacers: Insights from a Mitogenomic Comparison of Prosopocoilus Stag Beetles (Coleoptera: Lucanidae)
Authors: Xu Mengqiong , Zhou Shiju , Wan Xia
Published: June 2022

To explore the characteristics of mitogenomes and discuss the phylogenetic relationships within the genus Prosopocoilus, the mitogenomes of two species (P. castaneus and P. laterotarsus) were newly sequenced and comparatively analyzed. The arrangement of the mitogenome in these two lucanid beetles was the same as that in the inferred ancestral insect, and the nucleotide composition was highly biased towards A + T as in other lucanids. The evolutionary rates of 13 protein-coding genes (PCGs) suggested that their evolution was based on purifying selection. Notably, we found evidence of the presence of a large IGS between trnI and trnQ genes, whose length varied from 375 bp (in P. castaneus) to 158 bp (in P. laterotarsus). Within the large IGS region, a short sequence (TAAAA) was found to be unique among these two species, providing insights into phylogenomic reconstruction. Phylogenetic analyses were performed using the maximum likelihood (IQ-TREE) and Bayesian (PhyloBayes) methods based on 13 protein-coding genes (PCGs) in nucleotides and amino acids (AA) from published mitogenomes (n = 29). The genus Prosopocoilus was found to constitute a distinct clade with high nodal support. Overall, our findings suggested that analysis of the characteristics of the large IGS (presence or absence, size, and location) in mitogenomes of the genus Prosopocoilus may be informative for the phylogenetic and taxonomic analyses and for evaluation of the genus Prosopocoilus, despite the dense sampling materials needed.
High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers
Authors: Han Miaomiao , Fu Xinsen , Xin Xiangqi , Dong Yuanyang , Miao Zhiqiang , Li Jianhui
Published: June 2022

Although Iron (Fe) is an essential nutrient that plays a vital role in respiratory processes, excessive Fe in the diet can affect the health of broilers. We investigated the effects of diet supplemented with high levels of iron chelates with lysine and glutamic acid (Fe–LG) on the growth performance, serum biochemical parameters, antioxidant status, and duodenal mRNA expression of Fe transporters in broilers. A total of 800 1-day-old male Arbor Acres broilers were assigned to 5 groups, with 8 replicates each. Broilers were fed a corn–soybean meal basal diet or basal diets supplemented with 40, 80, 400, or 800 mg Fe/kg as Fe–LG for 6 weeks. The body weight (BW) was increased in the 80 mg Fe/kg treatment group, but decreased in the 800 mg Fe/kg treatment group on day 21. During days 1–21, compared with the control group, the supplementation of the 80 mg Fe/kg increased the average daily gain (ADG) and average daily feed intake (ADFI); however, the supplementation of the 800 mg Fe/kg group decreased the ADG and increased the FCR in broilers (p < 0.05). The heart, liver, spleen, and kidney indices were reduced in the 800 mg Fe/kg treatment group (p < 0.05). The supplementation of the 800 mg Fe/kg group increased the serum aspartate aminotransferase activity and the levels of creatinine and urea nitrogen on day 42 (p < 0.05). The broilers had considerably low liver total superoxide dismutase activity and total antioxidant capacity in the 800 mg Fe/kg treatment group (p < 0.05). Serum and liver Fe concentrations were elevated in the 400 and 800 mg Fe/kg treatment groups, but were not affected in the 40 and 80 mg Fe/kg treatment groups. The duodenal Fe transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) were downregulated in the Fe–LG treatment groups (p < 0.05). We conclude that a high dietary supplement of 800 mg Fe/kg in broilers leads to detrimental health effects, causing kidney function injury and liver oxidative stress.
Regional Variations in Outpatient Antibiotic Prescribing in Germany: A Small Area Analysis Based on Claims Data
Authors: Scholle Oliver , Asendorf Marieke , Buck Christoph , Grill Susann , Jones Christopher , Kollhorst Bianca , Riedel Oliver , Schüz Benjamin , Haug Ulrike
Published: June 2022

A comprehensive small area description of regional variations in outpatient antibiotic prescribing in Germany is lacking. Using the German Pharmacoepidemiological Research Database (GePaRD), a claims database covering ~20% of the German population, we determined the age- and sex-standardized prescription rates of antibiotics (number of outpatient prescriptions per 1000 persons/year). We calculated these prescription rates overall and on the level of 401 German districts for the calendar years 2010 and 2018. In 2018, the standardized prescription rate of antibiotics in the total study population was 23% lower than in 2010 (442 vs. 575 per 1000 persons/year). Among 0–17-year-olds, prescription rates across districts ranged from 312 to 1205 in 2010 and from 188 to 710 in 2018 per 1000 persons/year; among adults (≥18 years), they ranged from 388 to 841 in 2010 and from 300 to 693 in 2018 per 1000 persons/year. Despite the overall decline in outpatient antibiotic prescribing between 2010 and 2018, regional variations at the district level remained high in all age groups in Germany. Identifying reasons that explain the persistently high prescription rates in certain regions will be helpful in designing effective and tailored measures to further improve antibiotic stewardship in these regions.
Protective Effects of Diets Rich in Polyphenols in Cigarette Smoke (CS)-Induced Oxidative Damages and Associated Health Implications
Authors: Rudrapal Mithun , Maji Siddhartha , Prajapati Shiv Kumar , Kesharwani Payal , Deb Prashanta Kumar , Khan Johra , Mohamed Ismail Randa , Kankate Rani S. , Sahoo Ranjan Kumar , Khairnar Shubham J. , Bendale Atul R.
Published: June 2022

Cigarette smoking has been responsible for causing many life-threatening diseases such as pulmonary and cardiovascular diseases as well as lung cancer. One of the prominent health implications of cigarette smoking is the oxidative damage of cellular constituents, including proteins, lipids, and DNA. The oxidative damage is caused by reactive oxygen species (ROS, oxidants) present in the aqueous extract of cigarette smoke (CS). In recent years, there has been considerable interest in the potential health benefits of dietary polyphenols as natural antioxidant molecules. Epidemiological studies strongly suggest that long-term consumption of diets (fruits, vegetables, tea, and coffee) rich in polyphenols offer protective effects against the development of cancer, cardiovascular diseases, diabetes, osteoporosis, and neurodegenerative diseases. For instance, green tea has chemopreventive effects against CI-induced lung cancer. Tea might prevent CS-induced oxidative damages in diseases because tea polyphenols, such as catechin, EGCG, etc., have strong antioxidant properties. Moreover, apple polyphenols, including catechin and quercetin, provide protection against CS-induced acute lung injury such as chronic obstructive pulmonary disease (COPD). In CS-induced health problems, the antioxidant action is often accompanied by the anti-inflammatory effect of polyphenols. In this narrative review, the CS-induced oxidative damages and the associated health implications/pathological conditions (or diseases) and the role of diets rich in polyphenols and/or dietary polyphenolic compounds against various serious/chronic conditions of human health have been delineated.
Effect of Depth on Ultrasound Point Shear Wave Elastography in an Elasticity Phantom
Authors: Almutairi Fahad F. , Abdeen Rawan , Alyami Jaber , Sultan Salahaden R.
Published: June 2022

Background: Phantom studies are widely used to assess variability in measurements. This study aimed to assess the reliability and accuracy of point Shear Wave elastography (pSWE) measurements of an elasticity phantom. Methods: Measurements were obtained by an experienced certified clinical sonographer at three different depth levels in kPa, using a curvilinear 5-1MHz transducer of the EPIQ7 ultrasound imaging system. Results: A total of 180 pSWE measurements were obtained at three different depth levels (three cm, five cm, and seven cm) of the phantom background. The mean CV of pSWE was low at all depths (3 cm: 8.8%; 5 cm: 7%; 7 cm: 7.2%). There was a significant difference between measurements at depths of 3 cm vs. 7 cm (MD: −0.85, 95% CI −1.5, −0.11, p = 0.024) and measurements at depths 5 cm vs. 7 cm (MD: −1.1, 95% CI −1.7, −0.47, p = 0.001). An overestimation of mean pSWE measurements at a depth of 7 cm was noted compared to the manufacturer’s value (2.7%, p = 0.006). Conclusions: Superficial phantom SWE measurements in this study had low variability compared to deep measurement. pSWE measurements at deep levels can be overestimated.
Unsupervised Anomaly Detection for Time Series Data of Spacecraft Using Multi-Task Learning
Authors: Yang Kaifei , Wang Yakun , Han Xiaodong , Cheng Yuehua , Guo Lifang , Gong Jianglei
Published: June 2022

Although in-orbit anomaly detection is extremely important to ensure spacecraft safety, the complex spatial-temporal correlation and sparsity of anomalies in the data pose significant challenges. This study proposes the new multi-task learning-based time series anomaly detection (MTAD) method, which captures the spatial-temporal correlation of the data to learn the generalized normal patterns and hence facilitates anomaly detection. First, four proxy tasks are implemented for feature extraction through joint learning: (1) Long short-term memory-based data prediction; (2) autoencoder-based latent representation learning and data reconstruction; (3) variational autoencoder-based latent representation learning and data reconstruction; and (4) joint latent representation-based data prediction. Proxy Tasks 1 and 4 capture the temporal correlation of the data by fusing the latent space, whereas Tasks 2 and 3 fully capture the spatial correlation of the data. The isolation forest algorithm then detects anomalies from the extracted features. Application to a real spacecraft dataset reveals the superiority of our method over existing techniques, and further ablation testing for each task proves the effectiveness of fusing multiple tasks. The proposed MTAD method demonstrates promising potential for effective in-orbit anomaly detection for spacecraft.
A Method of Multi-Objective Optimization and Multi-Attribute Decision-Making for Huangjinxia Reservoir
Authors: Wei Na , Yang Feng , Lu Kunming , Xie Jiancang , Zhang Shaofei
Published: June 2022

The objectives of flood control, power generation, water supply and ecology for reservoir operation are neither completely coordinated nor completely opposed, and its optimal operation and decision-making is very complicated. This study proposed a method of multi-objective optimization and multi-attribute decision making for reservoir operation (MODRO). The correlation analysis method was used to analyze the competitive relationship among the extracted objectives, and the multi-objective optimal operation model was constructed. The NSGA-II-SEABODE algorithm was applied to solve the MODRO problem. The objective extraction, model construction, optimization solution and scheme selection were coupled to form a multi-objective optimization and multi-attribute decision making method with the whole process of “Objective-Modeling-Optimization-Selection”. Huangjinxia Reservoir, which is located in Shaanxi, China, was selected as the case study. The results show that: (1) Quantifying the degree of conflict among objectives makes the construction of the multi-objective optimal operation model more reasonable. (2) The NSGA-II-SEABODE algorithm are used to obtain the decision-making scheme, which provides decision-making basis for managers. (3) For Huangjinxia Reservoir, water diversion is negatively related to power generation and ecology, and power generation is positively related to ecology. The results can promote the efficient utilization of water resources, improve the comprehensive benefits of reservoirs, and provide decision-making support for actual reservoir operation.
Electrochemical Control of Biofilm Formation and Approaches to Biofilm Removal
Authors: Brožková Iveta , Červenka Libor , Moťková Petra , Frühbauerová Michaela , Metelka Radovan , Švancara Ivan , Sýs Milan
Published: June 2022

This review deals with microbial adhesion to metal-based surfaces and the subsequent biofilm formation, showing that both processes are a serious problem in the food industry, where pathogenic microorganisms released from the biofilm structure may pollute food and related material during their production. Biofilm exhibits an increased resistance toward sanitizers and disinfectants, which complicates the removal or inactivation of microorganisms in these products. In the existing traditional techniques and modern approaches for clean-in-place, electrochemical biofilm control offers promising technology, where surface properties or the reactions taking place on the surface are controlled to delay or prevent cell attachment or to remove microbial cells from the surface. In this overview, biofilm characterization, the classification of bacteria-forming biofilms, the influence of environmental conditions for bacterial attachment to material surfaces, and the evaluation of the role of biofilm morphology are described in detail. Health aspects, biofilm control methods in the food industry, and conventional approaches to biofilm removal are included as well, in order to consider the possibilities and limitations of various electrochemical approaches to biofilm control with respect to potential applications in the food industry.
A Calculation Method of Thermal Pore Water Pressure Considering Overconsolidation Effect for Saturated Clay
Authors: Tian Gailei , Zhang Zhihong
Published: June 2022

With the increase of soil consolidation degree, the pore water pressure induced by thermal loading drops dramatically. To conveniently and quickly calculate the thermal pore water pressure inside the soil under different overconsolidation states and quantify overconsolidation effect on thermal pore water pressure, a calculation method of thermal pore water pressure considering overconsolidation effect for saturated clay is proposed. The method is verified by the relevant experimental data, and good agreements were achieved. Through analyzing the influence mechanism of OCR on the thermal pore water pressure, three important findings were captured. (1) For overconsolidated clay, thermal pore water pressure decreases nonlinearly with the increase of OCR. (2) There is a critical threshold of OCR 4.3; when 1 < OCR ≤ 4.3 (slightly overconsolidated state), the ratio of compression line slope to recompression line slope (Λ) of overconsolidated clay is consistent with that of the normally consolidated clay, while when OCR > 4.3 (highly overconsolidated state), the value of Λ is smaller than that of normally consolidated clay. (3) For highly overconsolidated clay (OCR > 4.3), considering the reducing of Λ with OCR, the prediction accuracy of the thermal pore pressure calculation method has been greatly improved; especially when OCR equals 30, the prediction accuracy improves by 92.7% as temperature change achieves 35 °C.
Study on the Surrounding Rock Pressure Characteristics of Loess Tunnel Based on Statistical Analysis in China
Authors: Hu Zhao , Zhang Jianwei , Yang Yongtai , Wang Zhichao , Xie Yongli , Qiu Junling , He Siyue , Wang Xiuling
Published: June 2022

A method of load calculation in a tunnel was adopted in consideration of the state of covering depth. Due to the macropore characteristics of loess soil, the existing demarcation regulations of deep and shallow tunnels are inappropriate for large-section and shallow loess in highway tunnels. To determine the load of large-section loess tunnel and provide a proper reference for structural design, the theoretical basis for distinguishing depth of deep and shallow tunnels, as well as the characteristics of common calculation methods for surrounding rock load on depth, were analyzed. Through statistical analysis and significance analysis, the significance of the variation of surrounding rock pressure with cover depth was studied. Correlation analysis was carried out on significant results to fit the relationship between cover depth and surrounding rock pressure. The results showed that the surrounding rock pressure varied linearly with the cover depth, and the surrounding rock pressure was about 0.3 times the initial pressure in deep tunnels. The surrounding rock pressure of shallow tunnels did not change significantly with the cover depth, and the surrounding rock pressure was loose pressure. A method based on statistics was proposed to distinguish the cover depth threshold (CDT) of deep and shallow tunnels.
Pearl Millet (Pennisetum glaucum) Seedlings Transplanting as Climate Adaptation Option for Smallholder Farmers in Niger
Authors: Traore Bouba , Moussa Abdourazak Alio , Traore Amadou , Abdel Nassirou Yahaya Seydou , Ba Malick N. , Tabo Ramadjita
Published: June 2022

Pearl millet is the most widely grown cereal crop in the arid and semi-arid regions of Africa, and in Niger in particular. To determine an optimized management strategy for smallholder farmers in southern Niger to cope with crop production failure and improve cropping performance in the context of climate change and variability, multi-site trials were conducted to evaluate the impacts of transplanting on pearl millet growth and productivity. Eight treatments viz. T1-0NPK (100% transplanting without NPK), T1-NPK (100% transplanting + NPK), T2-0NPK (100% transplanting of empty hills without NPK), T2-NPK (100% transplanting of empty hills + NPK), T3-0NPK (50% transplanting of empty hills without NPK), T3-NPK (50% transplanting of empty hills + NPK), T4-0NPK (farmer practice without NPK), and T4-NPK (farmer practice + NPK) were included in the experiment. Compared to farmer practice, transplanting significantly reduced time to tillering, flowering, and maturity stages by 15%, 27%, and 11%, respectively. The results also revealed that T1-NPK significantly increased panicle weight, total biomass, grain yield, and plant height by 40%, 38%, 27%, and 23%, respectively. Farmers’ evaluations of the experiments supported these findings, indicating three substantial advantages of transplanting, including higher yield (37.50% of responses), larger, more vigorous and more panicles (34.17% of responses), and good tillering (28.33% of responses). An economic profitability analysis of the system revealed that biomass gain (XOF 359,387/ha) and grain gain (XOF 324,388/ha) increased by 34% and 22%, respectively, with T1-NPK. Therefore, it can be inferred that transplanting is a promising strategy for adapting millet cultivation to climate change and variability in southern Niger.
Performance of CMIP6 HighResMIP on the Representation of Onset and Cessation of Seasonal Rainfall in Southern West Africa
Authors: Nkrumah Francis , Quagraine Kwesi Akumenyi , Quagraine Kwesi Twentwewa , Wainwright Caroline , Quenum Gandomè Mayeul Leger Davy , Amankwah Abraham , Klutse Nana Ama Browne
Published: June 2022

Changes in rainfall onset and cessation dates are critical for improving decision making and adaptation strategies in numerous socio-economic sectors. An objective method of determining onset and cessation date is employed over Southern West Africa (SWA) in this study. The method is applied over 34 years of the quasi-global rainfall dataset from the Climate Hazards Group InfraRed Precipitation with Stations (CHIRPS) and five High Resolution Model Intercomparison Project (HighResMIP) model datasets under the Coupled Model Intercomparison Project Phase 6 (CMIP6) experiment. Generally, a strong agreement exists between CHIRPS and the HighResMIP models in capturing the behaviour of seasonal rainfall over SWA, with models able to capture the bimodal rainfall season. The ability of models in capturing onset and cessation dates as observed in CHIRPS shows the strength of these models in representing the short break between the two wet seasons that is otherwise known as the ‘Little Dry Season’. Patterns observed in the onset and cessation dates over the SWA region are consistent with the northward and southward displacement of the Intertropical Convergence Zone (ITCZ). The seasonal timing of the models shows good agreement with observations such that most mean onset/cessation dates agree within 26 days. While IPSL-CM6A-ATM-HR, a model among the five HighResMIPs used in the study, best agrees with CHIRPS in representing onset and cessation dates during the unimodal rainfall season, no one model best agrees with CHIRPS during the bimodal season, with models outperforming each other in representing onset/cessation dates with little variation.
Impact of Preventive Measures on Subjective Symptoms and Antigen Sensitization against Japanese Cedar, Cypress Pollen and House Dust Mites in Patients with Allergic Rhinitis: A Retrospective Analysis in the COVID-19 Era
Authors: Oda Takashi , Maeda Fumiaki , Takeno Sachio , Tsuru Yuri , Ishikawa Chie , Ishino Takashi , Takemoto Kota , Hamamoto Takao , Ueda Tsutomu , Kawasumi Tomohiro , Iwamoto Hiroshi , Kubota Kazunori , Nakao Yoshio , Kunimoto Masaru
Published: June 2022

For >2 years, Japan’s government has been urging the populace to take countermeasures to prevent COVID-19, including mask wearing. We examined whether these preventive behaviors have affected the rate and degree of sensitization against pollen and house dust antigens in patients with allergic rhinitis. We retrospectively surveyed 2565 patients who had undergone allergy blood testing during the period 2015–2021. We subdivided this period into eras based on the COVID-19 pandemic: the pre-COVID (2015–2019, n = 1879) and COVID (2020–2021, n = 686) eras. The positive rates for Japanese cedar and cypress in the 40–59-year-olds and those for house dust in the 20–39-year-olds were significantly reduced in the COVID era versus those in the pre-COVID era. Each group’s mean antigen-specific CAP scores decreased significantly from the 1st to 2nd era: from 1.98 to 1.57 for cedar (p < 0.01), 1.42 to 0.95 for cypress (p < 0.05), and 2.86 to 2.07 for house dust (p < 0.01). Our survey of the patients’ clinical records indicates that 47.5% of the pollinosis patients reported improvement in nasal symptoms after the three seasons of pollen dispersion in the COVID era. Japan’s quarantine policies designed to combat the spread of COVID-19 thus coincide with pivotal measures to alleviate allergic reactions.
Comparative Analysis of Backbone Networks for Deep Knee MRI Classification Models
Authors: Shakhovska Nataliya , Pukach Pavlo
Published: June 2022

This paper focuses on different types of backbone networks for machine learning architectures which perform classification of knee Magnetic Resonance Imaging (MRI) images. This paper aims to compare different types of feature extraction networks for the same classification task, in terms of accuracy and performance. Multiple variations of machine learning models were trained based on the MRNet architecture, choosing AlexNet, ResNet, VGG-11, VGG-16, and Efficientnet as the backbone. The models were evaluated on the MRNet validation dataset, computing Area Under the Receiver Operating Characteristics Curve (ROC-AUC), accuracy, f1 score, and Cohen’s Kappa as evaluation metrics. The MRNet-VGG16 model variant shows the best results for Anterior Cruciate Ligament (ACL) tear detection. For general abnormality detection, MRNet-VGG16 is dominated by MRNet-Resnet in confidence between 0.5 and 0.75 and by MRNet-VGG11 for confidence more than 0.8. Due to the non-uniform nature of backbone network performance on different MRI planes, it is advisable to use an LR ensemble of: VGG16 on a coronal plane for all classification tasks; on an axial plane for abnormality and ACL tear detection; Alexnet on a sagittal plane for abnormality detection, and an axial plane for meniscal tear detection; and VGG11 on a sagittal plane for ACL tear detection. The results also indicate that the Cohen’s Kappa metric is valuable in model evaluation for the MRNet dataset, as it provides deeper insights on classification decisions.
Multi-Label Attribute Selection of Arrhythmia for Electrocardiogram Signals with Fusion Learning
Authors: Yang Jie , Li Jinfeng , Lan Kun , Wei Anruo , Wang Han , Huang Shigao , Fong Simon
Published: June 2022

There are three primary challenges in the automatic diagnosis of arrhythmias by electrocardiogram (ECG): the significant variation among individual patients, the multiple pathologies in the ECG signal and the high cost in annotating clinical ECG with the corresponding labels. Traditional ECG processing approaches rely heavily on prior knowledge, such as those from feature extraction and waveform analysis. The preprocessing for prior knowledge incurs computational overhead. Furthermore, standard deep learning methods do not fully consider the dynamic temporal, spatial and multi-labeling characteristics of ECG data. In clinical ECG waveforms, it is common to see multi-labeling in which a patient is labeled with multiple classes of arrhythmias. However, multiclass approaches in current research mainly solve the multi-label machine learning problem, ignoring the correlation between diseases, resulting in information loss. In this paper, an arrhythmia detection and classification scheme called multi-label fusion deep learning is proposed. The objective is to build a unified system with automatic feature learning which supports effective multi-label classification. First, a multi-label ECG-based feature selection method is combined with a matrix decomposition and sparse learning theory. The optimal feature subset is selected as a preprocessing algorithm for ECG data. A multi-label classifier is then constructed by fusing CNN and RNN networks to fully exploit the interactions and features of the time and space dimensions. The experimental result demonstrates that the proposed method can achieve a state-of-the-art performance compared to other algorithms in multi-label database experiments.
Life and Death Decisions—The Many Faces of Autophagy in Cell Survival and Cell Death
Authors: Yu Ge , Klionsky Daniel J.
Published: June 2022

Autophagy is a process conserved from yeast to humans. Since the discovery of autophagy, its physiological role in cell survival and cell death has been intensively investigated. The inherent ability of the autophagy machinery to sequester, deliver, and degrade cytoplasmic components enables autophagy to participate in cell survival and cell death in multiple ways. The primary role of autophagy is to send cytoplasmic components to the vacuole or lysosomes for degradation. By fine-tuning autophagy, the cell regulates the removal and recycling of cytoplasmic components in response to various stress or signals. Recent research has shown the implications of the autophagy machinery in other pathways independent of lysosomal degradation, expanding the pro-survival role of autophagy. Autophagy also facilitates certain forms of regulated cell death. In addition, there is complex crosstalk between autophagy and regulated cell death pathways, with a number of genes shared between them, further suggesting a deeper connection between autophagy and cell death. Finally, the mitochondrion presents an example where the cell utilizes autophagy to strike a balance between cell survival and cell death. In this review, we consider the current knowledge on the physiological role of autophagy as well as its regulation and discuss the multiple functions of autophagy in cell survival and cell death.
Risk of Malignancy in Patients with Asthma-COPD Overlap Compared to Patients with COPD without Asthma
Authors: Bonnesen Barbara , Sivapalan Pradeesh , Jordan Alexander , Pedersen Johannes Wirenfeldt , Bergsøe Christina Marisa , Eklöf Josefin , Toennesen Louise Lindhardt , Jensen Sidse Graff , Naqibullah Matiullah , Saghir Zaigham , Jensen Jens-Ulrik Stæhr
Published: June 2022

Chronic inflammation such as asthma may lead to higher risks of malignancy, which may be inhibited by anti-inflammatory medicine such as inhaled corticosteroids (ICS). The aim of this study was to evaluate if patients with asthma-Chronic Obstructive Pulmonary Disease (COPD) overlap have a higher risk of malignancy than patients with COPD without asthma, and, secondarily, if inhaled corticosteroids modify such a risk in a nationwide multi-center retrospective cohort study of Danish COPD-outpatients with or without asthma. Patients with asthma-COPD overlap were propensity score matched (PSM) 1:2 to patients with COPD without asthma. The endpoint was cancer diagnosis within 2 years. Patients were stratified depending on prior malignancy within 5 years. ICS was explored as a possible risk modifier. We included 50,897 outpatients with COPD; 88% without prior malignancy and 20% with asthma. In the PSM cohorts, 26,003 patients without prior malignancy and 3331 patients with prior malignancy were analyzed. There was no association between asthma-COPD overlap and cancer with hazard ratio (HR) = 0.92, CI = 0.78–1.08, p = 0.31 (no prior malignancy) and HR = 1.04, CI = 0.85–1.26, and p = 0.74 (prior malignancy) as compared to patients with COPD without asthma. ICS did not seem to modify the risk of cancer. In conclusion, in our study, asthma-COPD overlap was not associated with an increased risk of cancer events.
Assessing Cognitive Factors of Modular Distance Learning of K-12 Students Amidst the COVID-19 Pandemic towards Academic Achievements and Satisfaction
Authors: Jou Yung-Tsan , Mariñas Klint Allen , Saflor Charmine Sheena
Published: June 2022

The COVID-19 pandemic brought extraordinary challenges to K-12 students in using modular distance learning. According to Transactional Distance Theory (TDT), which is defined as understanding the effects of distance learning in the cognitive domain, the current study constructs a theoretical framework to measure student satisfaction and Bloom’s Taxonomy Theory (BTT) to measure students’ academic achievements. This study aims to evaluate and identify the possible cognitive capacity influencing K-12 students’ academic achievements and satisfaction with modular distance learning during this new phenomenon. A survey questionnaire was completed through an online form by 252 K-12 students from the different institutions of Occidental Mindoro. Using Structural Equation Modeling (SEM), the researcher analyses the relationship between the dependent and independent variables. The model used in this research illustrates cognitive factors associated with adopting modular distance learning based on students’ academic achievements and satisfaction. The study revealed that students’ background, experience, behavior, and instructor interaction positively affected their satisfaction. While the effects of the students’ performance, understanding, and perceived effectiveness were wholly aligned with their academic achievements. The findings of the model with solid support of the integrative association between TDT and BTT theories could guide decision-makers in institutions to implement, evaluate, and utilize modular distance learning in their education systems.
Environmental Impact on the Behavior of CFRP Sheet Attached to Concrete
Authors: Al-Khafaji Ayssar , El-Zohairy Ayman , Mustafic Mirnes , Salim Hani
Published: June 2022

Carbon fiber-reinforced polymer (CFRP) has many advantages as a construction/structural-strengthening material. However, there are still concerns regarding the long-term performance of these materials when used with reinforced concrete (RC) structures. Environmental conditions have an adverse effect on the behavior of CFRP and the bond between these sheets and concrete. Therefore, the durability of CFRP used for strengthening RC beams was evaluated under different environmental scenarios, including subjection to immersion in deicing agents, tap water, and saltwater, freeze-and-thaw cycles, and outdoor environmental changes. Laboratory tests were performed to examine the influence of these environmental scenarios on the bonding behavior between CFRP sheets and concrete in terms of deformations and modes of failure. Two types of test setups were performed in this study, namely pull-off shearing and three-point bending. Forty-two concrete prisms with CFRP were prepared and tested by using the pull-off shearing setup. It was observed that as the period of exposure increased, noticeable effects on the CFRP sheet as well as the bond stiffness were observed. Exposure to tap water had a greater impact than saltwater on the CFRP–concrete bond strength as well as the CFRP. In addition, eighteen notched concrete beams strengthened with an external CFRP were tested under three-point bending. The tap water exposure showed a 3.6% increase in the bond strength compared to the control specimen. However, the saltwater exposure showed a 10% increase.