bluuebunny/crossref_metadata_2025 huggingface dataset:
‘Colouring’ — Material Depiction in Flemish and Dutch Baroque Art Theory
Authors: Wiersma Lisa
Published: April 2020

Seventeenth-century painters were masters at painting objects and beings that seem tangible. Most elaborate was painting translucent materials like skins and pulp: human flesh and grapes, for instance, require various surface effects and suggest the presence of mass below the upper layers. Thus, the viewer is more or less convinced that a volume or object is present in an illusionary space. In Dutch, the word ‘stofuitdrukking’ is used: expression or indication of material, perhaps better understood as rendering of material. In English, ‘material depiction’ probably captures this painterly means best: it includes rendering of surface effects, while revealing the underlying substance, and it implies that weight and mass are suggested. Simple strokes of paint add up to materials and things that are convincingly percieved. At first glance, material depiction hardly seems a topic in early-modern art theory, yet 17th-century painters are virtually unequalled as regards this elaborate skill. Therefore, 17th-century written sources were studied to define how these might discuss material depiction, if not distinctly. This study concerns one of many questions regarding the incredible convincingness of 17th-century material depiction: besides wondering why the illusions work (Di Cicco et al., this issue) and how these were achieved (Wiersma, in press), the question should be asked why this convincingness was sought after. Was it mere display of ability and skill? And how was material depiction perceived, valued and enjoyed? First, contemporary terminology is determined: the seemingly generic term ‘colouring’ signified the application of convincing material depiction especially — which is not as self-evident as it sounds. Second, and extensively, the reader will find that convincing or appealing material depiction was considered a reference to religion and natural philosophy.
Assessing Systematic Impacts of PBL Schemes on Storm Evolution in the NOAA Warn-on-Forecast System
Authors: Potvin Corey K. , Skinner Patrick S. , Hoogewind Kimberly A. , Coniglio Michael C. , Gibbs Jeremy A. , Clark Adam J. , Flora Montgomery L. , Reinhart Anthony E. , Carley Jacob R. , Smith Elizabeth N.
Published: April 2020

The NOAA Warn-on-Forecast System (WoFS) is an experimental rapidly updating convection-allowing ensemble designed to provide probabilistic operational guidance on high-impact thunderstorm hazards. The current WoFS uses physics diversity to help maintain ensemble spread. We assess the systematic impacts of the three WoFS PBL schemes—YSU, MYJ, and MYNN—using novel, object-based methods tailored to thunderstorms. Very short forecast lead times of 0–3 h are examined, which limits phase errors and thereby facilitates comparisons of observed and model storms that occurred in the same area at the same time. This evaluation framework facilitates assessment of systematic PBL scheme impacts on storms and storm environments. Forecasts using all three PBL schemes exhibit overly narrow ranges of surface temperature, dewpoint, and wind speed. The surface biases do not generally decrease at later forecast initialization times, indicating that systematic PBL scheme errors are not well mitigated by data assimilation. The YSU scheme exhibits the least bias of the three in surface temperature and moisture and in many sounding-derived convective variables. Interscheme environmental differences are similar both near and far from storms and qualitatively resemble the differences analyzed in previous studies. The YSU environments exhibit stronger mixing, as expected of nonlocal PBL schemes; are slightly less favorable for storm intensification; and produce correspondingly weaker storms than the MYJ and MYNN environments. On the other hand, systematic interscheme differences in storm morphology and storm location forecast skill are negligible. Overall, the results suggest that calibrating forecasts to correct for systematic differences between PBL schemes may modestly improve WoFS and other convection-allowing ensemble guidance at short lead times.
A Mixture IRTree Model for Performance Decline and Nonignorable Missing Data
Authors: Huang Hung-Yu
Published: April 2020

In educational assessments and achievement tests, test developers and administrators commonly assume that test-takers attempt all test items with full effort and leave no blank responses with unplanned missing values. However, aberrant response behavior—such as performance decline, dropping out beyond a certain point, and skipping certain items over the course of the test—is inevitable, especially for low-stakes assessments and speeded tests due to low motivation and time limits, respectively. In this study, test-takers are classified as normal or aberrant using a mixture item response theory (IRT) modeling approach, and aberrant response behavior is described and modeled using item response trees (IRTrees). Simulations are conducted to evaluate the efficiency and quality of the new class of mixture IRTree model using WinBUGS with Bayesian estimation. The results show that the parameter recovery is satisfactory for the proposed mixture IRTree model and that treating missing values as ignorable or incorrect and ignoring possible performance decline results in biased estimation. Finally, the applicability of the new model is illustrated by means of an empirical example based on the Program for International Student Assessment.
A Tale of Two Forums: Employment Discrimination Outcomes in Arbitration and Litigation
Authors: Gough Mark
Published: April 2020

This article presents data from a novel survey of 1,256 employment plaintiff attorneys to test whether employee rights and remedies are affected by mandatory employment arbitration. By surveying attorneys directly about their most recent employment discrimination cases taken to verdict in arbitration and civil litigation, the author presents a systematic empirical comparison of outcomes between civil courts and arbitration with robust controls. The ability to control for the legal basis of the claim, defendant size, use of summary judgment, and attorney and plaintiff characteristics significantly improves on previous empirical research studies. Consistent with previous research, employee win rates in arbitration are lower than those found in state and federal court. In addition, monetary award amounts and percentage of claim amount awarded to employees who prevail in their cases are significantly lower in arbitration compared to outcomes in state and federal jury trials.
Joining of carbon fibres with aluminium structures – Processing and infiltration modelling
Authors: Marx Lukas , Liewald Mathias
Published: April 2020

Against the background of today's lightweight design, an innovative joining technique has been developed at the Institute for Metal Forming Technology/Stuttgart for combining aluminium sheet structures with carbon fabrics. During the process of Joining of Carbon Fibres with Aluminium Structures (JOCA process), two or more aluminium sheets with carbon fabric layers in-between are initially conductively heated up into the semi-solid material state by means of two adjacent electrodes of a welding gun. If heated up to a liquid share of 30% to 60%, the aluminium matrix infiltrates the carbon fabric resulting into a firm joint after solidification of the metal material. This publication provides an overview of the research results obtained by experimental and numerical investigations of the infiltration process achieved so far.
Fear of Death and Death Acceptance Among Bereaved Adults: Associations With Prolonged Grief
Authors: Gegieckaite Goda , Kazlauskas Evaldas
Published: April 2020

This study aimed to analyze fear of death and neutral acceptance of death after a significant loss and their associations with prolonged grief. The sample of the study included 239 bereaved participants. Time since the loss ranged from 6 to 72 months. We found that neutral acceptance of death was associated with older age, a natural cause of death, and the ability to find meaning in the death of a close one. Fear of death was negatively associated with the frequency of practicing religion. We found that fear of death but not neutral acceptance was significantly associated with prolonged grief symptoms.
Quantifying the Current Form of Cricket Teams and Predicting the Match Winner
Authors: Saikia Hemanta
Published: April 2020

The study tries to predict the outcome of Twenty20 cricket matches based on two prime skills of the game: batting and bowling. The two different measures, namely batting performance (BP) and adjusted combined bowling rate (ACBR), developed by Lemmer (2011, European Journal of Sport Science, vol. 13, pp. 200–206) and Lemmer (2012, European Journal of Sports Science, vol. 14, pp. S191–S196), respectively, are used to quantify the overall batting and bowling performances of cricket teams. The rationale of choosing BP is that it takes into consideration the match situation against which the runs are scored, and ACBR considers the strength of a batsman using wicket weights and adjusted number of runs conceded by the bowler along with the match situation. Both the measures, BP and ACBR, are combined to get the overall strength of a cricket team prior to the knock-out or play-off stage of any given tournament. Thereafter, the overall strength of a team is used to quantify the team’s current form. If the current form of Team A (say) is considerably higher than that of Team B (say), then it is predicted that Team A will win the match and vice-versa.
Setting Target Scores of Better Acceptability in Interrupted Limited Over Cricket Matches by Introducing the Concept ‘Makeup Factor’
Authors: Jayadevan V.
Published: April 2020

In the game of cricket, the advantage a team enjoys by doing better than what the par score demands at the time of interruption is something which should get distributed among rest of the overs. When the remaining overs get significantly reduced due to an interruption, as per the present methods, this entire advantage a team possesses at the time of interruption gets concentrated to a lesser number of overs, thus increasing their winning probability significantly. Makeup factor is a feature which makes a proportionate reduction in this advantage/disadvantage based on the proportion of the remaining overs after interruption to the originally remaining overs at the time of interruption.
Application of Sharpe Ratio to Rank the Performance of Wicketkeepers in Cricket: A Study Based on Last Five IPL Seasons
Authors: Choudhury Deepjyoti , Bhattacharjee Dibyojyoti
Published: April 2020

The importance of wicketkeeper in a cricket team is indispensable. A perfect wicketkeeper keeps the morale of the team high and acts as the confidence booster to the bowler and the entire team. The performance of a wicketkeeper in a match can change the fate of the game. A wicketkeeper should be capable of several cricketing skills like stamping, catching and appealing for a dismissal and in these days an important decision maker of call for a decision review. However, the International Cricket Council (ICC), which regularly publishes ranking for batsman, bowlers, all-rounders and cricket teams, do not produce any ranking for wicketkeepers. Thus, considering the importance of a wicketkeeper in a cricket team, the researchers feel that it is necessary to identify the performance of wicketkeeper. The exercise can help in selecting the best keeper for a team from a host of available options. In this study an attempt has been made to rank the performance of wicketkeepers with the help of Sharpe ratio. Here the score card of wicket keeping data of selected players are taken from last five editions of Indian Premiere League (IPL) and accordingly the wicketkeeper with most expected number of dismissals is extracted. Based on the descriptive statistics, the sharpe ratio is calculated to identify and rank of the wicketkeepers.
Acute and episodic vestibular syndromes caused by ischemic stroke: predilection sites and risk factors
Authors: Tong DaoMing , Chen XiaoDong , Wang YuanWei , Wang Ying , Du Li , Bao JunJie
Published: April 2020

Objective

This study was performed to investigate the predilection sites of acute vestibular syndrome (AVS) and episodic vestibular syndrome (EVS) caused by acute infarcts.

Methods

This retrospective cohort study was performed at a stroke center in a tertiary teaching hospital. We diagnosed patients with AVS/EVS caused by acute ischemic stroke using diffusion-weighted imaging (DWI) and magnetic resonance angiography.

Results

Among all patients with AVS/EVS, 68 had DWI-positive ischemic events and 113 had DWI-negative ischemic events. Of the 68 patients with positive DWI findings, 42.6% had acute infarcts in the anterior circulation and 41.2% had acute infarcts in the posterior circulation. The main stroke predilection sites were the insular cortex (22.1%) and posterior thalamus (11.8%). Large vessel stenosis/occlusion (odds ratio, 0.12; 95% confidence interval, 0.04–0.36) and focal neurological symptoms/signs (odds ratio, 0.27; 95% confidence interval, 0.10–0.72) were significantly associated with the risk of AVS/EVS in patients with acute ischemic stroke.

Conclusions

The main predilection sites of AVS/EVS caused by ischemic stroke are the insular cortex and posterior thalamus. The risk of AVS/EVS is associated with large vessel stenosis and focal symptoms.
Development and application of a preliminary design methodology for modern low emissions aero combustors
Authors: Liu Yize , Sun Xiaoxiao , Sethi Vishal , Li Yi-Guang , Nalianda Devaiah , Abbott David , Gauthier Pierre , Xiao Bairong , Wang Lu
Published: April 2020

In this article, a preliminary design framework containing a detailed design methodology is developed for modern low emissions aero combustors. The inter-related design elements involving flow distribution, combustor sizing, heat transfer and cooling, emission and performance are coupled in the design process. The physics-based and numerical methods are provided in detail, in addition to empirical or semi-empirical methods. Feasibility assessment on the developed work is presented via case studies. The proposed combustor sizing methodology produces feasible combustor dimensions against the public-domain low emissions combustors. The results produced by the physics-based method show a reasonable agreement with experimental data to represent NOx emissions at key engine power conditions. The developed emission prediction method shows the potential to assess current and future technologies. A two-dimensional global prediction on liner wall temperature distribution for different cooling systems is reasonably captured by the developed finite difference method. It can be of use in the rapid identification of design solutions and initiating the optimisation of the design variables. The altitude relight efficiency predicted shows that the method could be used to provide an indicative assessment of combustor altitude relight capability at the preliminary design phase. The methodology is applied and shows that it enables the automatic design process for the development of a conceptual lean staged low emissions combustor. The design evaluation is then performed. A sensitivity analysis is carried out to assess the design uncertainties. The optimisation of the air distribution and cooling geometrical parameters addresses the trade-off between the NOx emissions and liner wall cooling, which demonstrates that the developed work has potential to identify and solve the design challenges at the early stages of the design process.
Mechanical Stimulation of Fibroblasts by Extracorporeal Shock Waves: Modulation of Cell Activation and Proliferation Through a Transient Proinflammatory Milieu
Authors: Basoli Valentina , Chaudary Sidrah , Cruciani Sara , Santaniello Sara , Balzano Francesca , Ventura Carlo , Redl Heniz , Dungel Peter , Maioli Margherita
Published: April 2020

Extracorporeal shock waves (ESWTs) are “mechanical” waves, widely used in regenerative medicine, including soft tissue wound repair. Although already being used in the clinical practice, the mechanism of action underlying their biological activities is still not fully understood. In the present paper we tried to elucidate whether a proinflammatory effect may contribute to the regenerative potential of shock waves treatment. For this purpose, we exposed human foreskin fibroblasts (HFF1 cells) to an ESWT treatment (100 pulses using energy flux densities of 0.19 mJ/mm2 at 3 Hz), followed by cell analyses after 5 min, up to 48 h. We then evaluated cell proliferation, reactive oxygen species generation, ATP release, and cytokine production. Cells cultured in the presence of lipopolysaccharide (LPS), to induce inflammation, were used as a positive control, indicating that LPS-mediated induction of a proinflammatory pattern in HFF1 increased their proliferation. Here, we provide evidence that ESWTs affected fibroblast proliferation through the overexpression of selected cytokines involved in the establishment of a proinflammatory program, superimposable to what was observed in LPS-treated cells. The possibility that inflammatory circuits can be modulated by ESWT mechanotransduction may disclose novel hypothesis on their biological underpinning and expand the fields of their biomedical application.
The Only Constant Is Change? Movement Capital and Perceived Employability
Authors: Peeters Ellen R. , Akkermans Jos , De Cuyper Nele
Published: April 2020

This study examines to what extent the four aspects of movement capital (i.e., human capital, adaptability, self-awareness, and social capital) contribute to individuals’ perceived employability. Building on the model of career mobility, we expected positive effects of all movement capital aspects on perceived employability over time. Hypotheses were tested by means of longitudinal structural equation models in two samples of Belgian respondents from the private ( N = 409, 6 months between measurements) and the public ( N = 718, 8 months between measurements) sector. We established a reciprocal relationship between self-awareness and perceived employability. The other associations of human capital, adaptability, and social capital were surprisingly small and inconsistent. There appears to be a disconnect between conceptualizations and measurements of employability; whereas conceptualizations of perceived employability focus on obtaining and retaining employment, measurements only tap into the former. At the same time, movement capital conceptualizations focus on obtaining employment, whereas their measurements tap into obtaining and retaining employment.
Romantic Relationships and Sexual Behavior Among Adolescents With ADHD
Authors: Margherio Samantha M. , Capps Elizabeth R. , Monopoli John W. , Evans Steven W. , Hernandez-Rodriguez Melissa , Owens Julie Sarno , DuPaul George J.
Published: April 2020

Objective: Both qualitative and quantitative analyses were used to (a) describe the romantic and sexual relationships of adolescents with ADHD and (b) examine how ADHD-related impairments (e.g., social skill deficits and emotion dysregulation [ED]) are associated with romantic relationship outcomes in this group. Method: Adolescents with ADHD ( N = 171; 80% male; 70% White) responded to questions about their romantic and sexual relationship experiences and ED. Parents provided ratings of ADHD symptoms, ED, and social skills. Results: Adolescents with ADHD reported high rates of romantic relationship turnover and low rates of physical intimacy. More severe self-reported ED was associated with increased likelihood of engaging in romantic relationships, having more romantic relationship partners, increased likelihood of engaging in sexual intercourse, and increased likelihood of engaging in unprotected sex. Conclusion: Early intervention programs that alter the developmental trajectory of romantic relationships among individuals with ADHD may benefit from targeting ED among these youth.
Peer Victimization and Poor Academic Outcomes in Adolescents With ADHD: What Individual Factors Predict Risk?
Authors: Zendarski Nardia , Breaux Rosanna , Eadeh Hana-May , Smith Zoe R. , Molitor Stephen J. , Mulraney Melissa , Bourchtein Elizaveta , Green Cathrin D. , Sciberras Emma
Published: April 2020

Objective: Examine individual factors associated with peer victimization (PV) in adolescents with attention-deficit/hyperactivity disorder (ADHD) and to examine the association between PV and educational outcomes. Method: Participants were 121 adolescents ( Mage = 13.62, SD = 1.03; 89% boys) with diagnosed ADHD. Using path analysis, we tested whether general adolescent factors (ADHD symptoms, comorbid autism spectrum disorder, cognitive and social functioning, and age) were associated with experiences of PV, and associations between PV and academic outcomes. Results: Deficits in working memory (WM) and peer relationship problems were weakly and moderately associated with PV, respectively. PV was in turn was associated with adolescents’ attitudes about school, academic competence, and academic achievement. Conclusion: Adolescents with poor social skills and/or WM difficulties who have ADHD may be particularly vulnerable to being victimized by peers. Failure to identify and manage PV during early adolescence may be connected to poor educational outcomes.
Modified relative dose response values differ between lactating women in the United States and Indonesia
Authors: Sheftel Jesse , Bresnahan Kara A , Fadjarwati Tetra , Tanumihardjo Sherry A
Published: April 2020

The modified relative dose response (MRDR) test distinguishes between vitamin A (VA) deficiency and sufficiency using the molar ratio of 3,4-didehydroretinol to retinol (DR:R) in serum 4–6 h after administering 3,4-didehydroretinyl acetate (DRA). Research in sows demonstrated that serum and milk DR:R are correlated. Two studies determined VA status in lactating women and investigated breast milk as a surrogate for serum in the MRDR test in VA-adequate women. A secondary outcome compared serum with milk carotenoids in US women. Lactating US (24–40 years old, n =  25) and Indonesian (22–40 years old, n =  18) women were given 8.8 µmol DRA. Subjects were allocated to three collections (3–48 h post-dose) for blood and milk ( n =  4–10/time point). DR, retinol, and carotenoids were determined by HPLC. Serum DR:R time-courses were evaluated in all women and DR kinetics analyzed by noncompartmental modeling in the US and VA-deficient Indonesian women. Indonesian women had a higher proportion of VA deficiency by MRDR (61%) than US women (0%). Milk DR concentration was higher than serum. In US women, serum and milk DR:R were correlated at 5 h ( r =  0.86, P <  0.01) but not at 6 or 7 h. Serum DR kinetics ( tmax = 8, t1/2 = 15.3 h) were similar to those in VA-adequate lactating sows ( tmax = 7.5 ± 1.9, t1/2 = 17.4 ± 4.5 h) but varied in milk (human: tmax = 12, t1/2 = 22.4 h; sow: tmax = 14.4 ± 9.8, t1/2 = 71.8 ± 51.2 h). Carotenoids in milk differed from serum ( P <  0.001), with β-cryptoxanthin enrichment. Serum but not milk VA kinetics were similar between women and sows. Milk DR:R may represent a simpler VA biomarker in lactating women vulnerable to VA deficiency, but requires further validation.

Impact statement

Vitamin A (VA) deficiency is a major health issue globally, and lactating women are particularly vulnerable due to increased needs for milk production. Accurate detection of VA deficiency is important; however, most population surveys measure VA status using serum retinol, which is affected by inflammation and lacks sensitivity. The modified relative dose response (MRDR) test qualitatively distinguishes between VA deficiency and sufficiency and could improve population surveys if completed in a randomly selected subsample of individuals in surveys. The original relative dose response test required two blood samples, while MRDR requires only one, a significant improvement in accessibility of the technique by decreasing burden on subjects and investigators. This work demonstrates significant deficiency in Indonesian women compared with US women. In combination with previous research using lactating sows, these human data support milk as a surrogate for blood in the MRDR, which may be less invasive, but requires further validation.
Bone Graft Harvesting From the Calcaneus Using Lateral Wall Corticotomy Technique by an Osteotome
Authors: Khademi Farough , Erfani Amirhossein , Erfani Mohammad Ali , Vosoughi Amir Reza
Published: April 2020

Background: The aim of this study was to evaluate the complications following calcaneal autologous bone graft harvesting using an osteotome in patients who underwent foot and ankle surgery with follow-up of at least 1 year. Methods: In a cohort study, all consecutive patients underwent forefoot or midfoot surgeries in conjunction with harvesting bone graft from the calcaneus using lateral wall corticotomy technique by an osteotome from 2015 till 2018 were asked to follow. The outcome and morbidity were assessed by visual analogue scale (VAS) pain, numbness in territory of the sural nerve, surgical site numbness or tenderness, infection, hematoma formation, or pathologic fracture. Also any possible restrictions on wearing desired shoes were asked. Results: Totally, 50 patients (11 males, 39 females; 29 right foot, 21 left foot) with the mean age of 48.2 ± 13.8 years (range 8-66 years) were assessed. There were no major complications on donor site such as infection, hematoma formation, or pathologic fracture. The following results were seen; 90% without any pain (VAS 0/10), 96% without numbness at the incision site, 96% without point tenderness on lateral of heel, 98% without paresthesia or numbness in the sural nerve territory, and 84% were able to wear their favorite shoes. Forty-one (82%) cases said if they need another foot surgery, they would permit to harvest bone graft from their heel. Conclusions: Autologous bone graft harvesting from the calcaneus using lateral wall corticotomy technique by an osteotome could be a useful method with very low complications.

Levels of Evidence: Therapeutic, level IV: cohort, case series
The state acts through the market: ‘State entrepreneurialism’ beyond varieties of urban entrepreneurialism
Authors: Wu Fulong
Published: April 2020

This commentary reflects on varieties of urban entrepreneurialism and rethinks its application to China. I argue that the state is proactively using market instruments for more strategic and developmental objectives in China. Characterized by ‘planning centrality, market instruments’, state entrepreneurialism manifests a different state–market relation: the state acts through the market rather than just being market friendly. In the post-crisis West, it is claimed that urban entrepreneurialism mutates into a financialized value extraction machine. Similarly, state entrepreneurialism reveals the usefulness but also the limits of the concept of urban entrepreneurialism. State entrepreneurialism adds a new narrative to the current description of governance changes associated with financialization and market operations.
Clinical Characteristics and Outcomes After Primary ACL Reconstruction and Meniscus Ramp Repair
Authors: DePhillipo Nicholas N. , Dornan Grant J. , Dekker Travis J. , Aman Zachary S. , Engebretsen Lars , LaPrade Robert F.
Published: April 2020

Background:

Satisfactory outcomes have been reported after all-inside meniscus ramp repair with combined anterior cruciate ligament reconstruction (ACLR). However, clinical outcomes after ACLR with inside-out meniscus ramp repair are limited.

Purpose/Hypothesis:

The purpose of this study was to evaluate patient-reported outcomes for patients who underwent ACLR and medial meniscus ramp repair compared with those who underwent isolated ACLR; patients in the 2 groups were matched for age, sex, and sport/activity. The null hypothesis was that there would be no significant differences in clinical outcomes between groups at a minimum of 2 years postoperatively.

Study Design:

Cohort study; Level of evidence 3.

Methods:

Patients who underwent primary ACLR with bone–patellar tendon–bone (BPTB) autograft by a single surgeon were retrospectively identified. A subgroup of patients with combined ACLR and meniscus ramp repair with a minimum 2-year postoperative follow-up were matched to a cohort who underwent isolated ACLR. Subjective patient-reported questionnaires, knee stability, and return to level of activity/sport were collected.

Results:

There were 851 patients who underwent primary ACLR; of these, 158 (18.6%) had medial meniscus ramp lesions confirmed at arthroscopy. The most common clinical characteristics in patients with ramp lesions were chronic injuries (68.4%), contact mechanism (88%), concomitant lateral meniscus tears (63.2%), and concomitant lateral meniscus posterior root tears (22.2%). Further, 50 patients who underwent combined ACLR and meniscus ramp repair with minimum 2-year follow-up were matched to patients who underwent isolated ACLR. Both groups reported significant improvements in subjective outcomes from preoperative to postoperative assessments ( P < .001). No significant differences were found in postoperative outcomes for combined ACLR with ramp repair versus isolated ACLR ( P > .05). Patients with meniscus ramp repair had increased preoperative knee laxity demonstrated by grade 3 Lachman (44% vs 6%) and pivot-shift (38% vs 12%) test results compared with patients who underwent isolated ACLR ( P ≤ .005 for both).

Conclusion:

This study demonstrates similar clinical outcomes, knee stability on postoperative physical examination, and return-to-sport rates for patients who underwent combined ACLR with BPTB autograft and inside-out meniscus ramp repair versus a matched cohort who underwent isolated ACLR. Clinicians should have a high index of suspicion for the presence of ramp lesions in patients with ACL tears who have a contact mechanism of injury, grade 3 Lachman test result, and concomitant lateral meniscal abnormality.
An annotated translation of the ‘eye disease incantation’ in Dongba script
Authors: He Jiquan , Zhao Xiuyun
Published: April 2020

The ‘eye disease incantation’ is a special category of manuscript recorded by the Naxi Dongba for the purpose of healing through the power of incantation and meditation. Up to now, very few Dongba texts with incantations have been discovered or published, and Dongba texts which record incantations as well as depict scenes of meditation are even more rare. There are three ways to record Dongba script found in these texts: record the language completely; express the meaning via pictures; and create an expression that combines meaning and sound. The structure of the glyphs is characteristic of an early writing system which was mainly composed of pictographs and associative compounds. However, the high rate of phonetic loan glyphs and the appearance of pictophonetic glyphs show the characteristics of a mature writing system. This type of manuscript has value for studying the evolution of the relationship between Dongba language and script, and shamanic healing culture.
Sexual Disorders: Progress Made and Way Ahead
Authors: Avasthi Ajit , Grover Sandeep , Rao T. S. Sathyanarayana
Published: April 2020

Although sexuality has a long history in the Indian literature, it is not discussed openly due to various reasons. Although sexual medicine has seen a reasonable growth in the last 70 years, somehow, psychological factors associated with the development of various sexual dysfunctions have not received due importance. Cultural factors which contribute to development and persistence of sexual disorders have not been evaluated properly. In terms of training, there is a wide variation across different centers in this country. There are very few indigenously designed instruments for the assessment of sexual disorders and there is limited data on well-evaluated indigenously designed interventions for the management of various sexual disorders. There is a need to homogenize the training and liaise with other specialists working in this area. Centers with well-developed services for sexual disorders need to start observerships and postdoctoral fellowship programs to train the interested clinicians. There is a need for multicentric studies to generate national-level data.
Pathways to Cybersex: Case-Report-Based Exploration
Authors: Sharma Manoj Kumar , Anand Nitin , J. Ajith S. , Thakur Pranjali Chakraborty , N. Suma , Sahu Maya , John Nisha , Tapatrikar Ashwini , Biswas Ankita , Vishwakarma Akash , R. Archana , Singh Priya , Murthy Keshava D.
Published: April 2020

The internet has become the preferred platform for use of webcam. The interactive online aspect of webcamming allows participants to have stimulating enjoyable experience for each act. There has been an increasing trend in users seeking help from the service for healthy use of technology (SHUT) specialty clinic for the management of pornography use. Clinical interviews were used to elicit details about their concern. The cases demonstrated the role of online behaviors especially cybersex in managing stress, free time, loneliness, boredom, as well as the need for novelty. It implies the need for screening the pathways to cybersex as well as to evolve intervention to manage these pathways in an Indian context.
Langhofite, Pb2(OH)[WO4(OH)], a new mineral from Långban, Sweden
Authors: Holtstam Dan , Cámara Fernando , Karlsson Andreas
Published: April 2020

Langhofite, ideally Pb2(OH)[WO4(OH)], is a new mineral from the Långban mine, Värmland, Sweden. The mineral and its name were approved by the International Mineralogical Association Commission on New Minerals, Nomenclature and Classification (IMA2019-005). It occurs in a small vug in hematite–pyroxene skarn associated with calcite, baryte, fluorapatite, mimetite and minor sulfide minerals. Langhofite is triclinic, space group P$\bar{1}$, and unit-cell parameters a = 6.6154(1) Å, b = 7.0766(1) Å, c = 7.3296(1) Å, α = 118.175(2)°, β = 94.451(1)°, γ = 101.146(1)° and V = 291.06(1) Å3 for Z = 2. The seven strongest Bragg peaks from powder X-ray diffractometry are [dobs, Å (I)(hkl)]: 6.04(24)(010), 3.26(22)(11$\bar{2}$), 3.181(19)(200), 3.079(24)(1$\bar{1}$2), 3.016(100)(020), 2.054(20)(3$\bar{1}$1) and 2.050(18)(13$\bar{2}$). Langhofite occurs as euhedral crystals up to 4 mm, elongated along the a axis, with lengthwise striation. Mohs hardness is ca. 2½, based on VHN25 data obtained in the range 130–192. The mineral is brittle, with perfect {010} and {100} cleavages. The calculated density based on the ideal formula is 7.95(1) g⋅cm–3. Langhofite is colourless to white (non-pleochroic) and transparent, with a white streak and adamantine lustre. Reflectance curves show normal dispersion, with maximum values 15.7–13.4% within 400–700 nm. Electron microprobe analyses yield only the metals Pb and W above the detection level. The presence of OH-groups is demonstrated with vibration spectroscopy, from band maxima present at ~3470 and 3330 cm–1. A distinct Raman peak at ca. 862 cm–1 is related to symmetric W–oxygen stretching vibrations. The crystal structure is novel and was refined to R = 1.6%. It contains [W2O8(OH)2]6– edge-sharing dimers (with highly distorted WO6-octahedra) forming chains along [101] with [(OH)2Pb4]6+ dimers formed by (OH)Pb3 triangles. Chains configure (010) layers linked along [010] by long and weak Pb–O bonds, thus explaining the observed perfect cleavage on {010}. The mineral is named for curator Jörgen Langhof (b. 1965), who collected the discovery sample.
Mortality among children under five years admitted for routine care of severe acute malnutrition: a prospective cohort study from Kampala, Uganda
Authors: Nalwanga Damalie , Musiime Victor , Kizito Samuel , Kiggundu John Baptist , Batte Anthony , Musoke Philippa , Tumwine James K.
Published: April 2020

Background

Mortality among children under 5 years of age admitted to malnutrition units in sub-Saharan Africa remains high. The burden of HIV infection, a major risk factor for mortality among patients with severe acute malnutrition (SAM), has reduced due to concerted prevention and treatment strategies. None the less, anecdotal reports from the malnutrition unit at Uganda’s National Referral Hospital (NRH) indicate that there is high mortality among patients with severe acute malnutrition (SAM) in routine care. Uganda has recently adopted the revised World Health Organization (WHO) treatment guidelines for SAM to improve outcomes. The mortality among children with SAM in routine care has not been recently elucidated. We report the magnitude and factors associated with mortality among children under 5 years of age admitted to the NRH for routine care of SAM.

Methods

This was a cohort study of all severely malnourished children admitted to the NRH between June and October 2017. The primary outcome was two-week mortality. Mortality was calculated using simple proportions and Cox regression analysis was used to determine factors associated with time to mortality. Data was entered into Epidata and analysed using Stata v14.

Results

Two-hundred-sixty (98.5%) children: 59.6% male; mean age 14.4 (SD 9.4) months, completed two weeks of follow-up. Of these, 25.2% (95% CI 19.9–30.4%) died. In-hospital mortality was 20.7% (95% CI15.9–25.6%). The prevalence of HIV infection was 12.2%. Factors associated with mortality included: positive HIV status (AHR 2.2, (95% CI; 1.2–4.2),p = 0.014), bacteraemia (AHR 9 (95% CI 3.4–23.0),p < 0.001, and low glomerular filtration rate (eGFR), AHR 3.2; (95% CI 1.7–6.3),p = 0.001).

Conclusions

A 25% mortality among children with severe malnutrition remains unacceptably high despite significant reduction in HIV prevalence. Children with SAM who are HIV infected, have eGFR below 60 mL/min/1.73m2or have bacteraemia, are more likely to die. Further studies to explore the relationship between eGFR and mortality among children with SAM are needed. Studies to establish efficacious antibiotics are urgently required to inform treatment guidelines for children with SAM.
Strengthening prehospital clinical practice guideline implementation in South Africa: a qualitative case study
Authors: McCaul Michael , Young Taryn , Bruijns Stevan R. , Clarke Mike
Published: April 2020

Background

Methods on developing new (de novo) clinical practice guidelines (CPGs) have received substantial attention. However, research into alternative methods of CPG development using existing CPG documents (CPG adaptation) — a specific issue for guideline development groups in low- and middle-income countries — is sparse. There are only a few examples showcasing the pragmatic application of such alternative approaches in settings with time and budget constraints, especially in the prehospital setting. This paper aims to describe and strengthen the methods of developing prehospital CPGs using alternative guideline development methods through a case study design.

Methods

We qualitatively explored a CPG development project conducted in 2016 for prehospital providers in South Africa as a case study. Key stakeholders, involved in various processes of the guideline project, were purposefully sampled. Data were collected from one focus group and six in-depth interviews and analysed using thematic analysis. Overarching themes and sub-themes were inductively developed and categorised as challenges and recommendations and further transformed into action points.

Results

Key challenges revolved around guideline implementation as opposed to development. These included the unavoidable effect of interest and beliefs on implementing recommendations, the local evidence void, a shifting implementation context, and opposing end-user needs. Guideline development and implementation strengthening priority actions included: i) developing a national end-user document; ii) aligning recommendations with local practice; iii) communicating a clear and consistent message; iv) addressing controversial recommendations; v) managing the impact of interests, beliefs and intellectual conflicts; and vi) transparently reporting implementation decisions.

Conclusion

The cornerstone of a successful guideline development process is the translation and implementation of CPG recommendations into clinical practice. We highlight key priority actions for prehospital guideline development teams with limited resources to strengthen guideline development, dissemination, and implementation by drawing from lessons learnt from a prehospital guideline project conducted in South Africa.
Publisher Correction: Survival analysis of Rural Clinical School of Western Australia graduates: the long-term work of building a long-term rural medical workforce
Authors: Gupta Surabhi , Ngo Hanh , Burkitt Tessa , Puddey Ian , Playford Denese
Published: April 2020

In the original publication of this article [1], an error occurred during the publication of this article in Table 2.
Exosomal miRNAs in hepatitis B virus related liver disease: a new hope for biomarker
Authors: Bandopadhyay Manikankana , Bharadwaj Mausumi
Published: April 2020

The World Health Organisation, in its 2019 progress report on HIV, viral hepatitis and STDs indicates that 257 million people are afflicted with chronic HBV infections, of which, 1 million patients lose their lives every year due to HBV related chronic liver diseases including serious complications such as liver cirrhosis and hepatocellular carcinoma. The course of HBV infection and associated liver injury depend on several host factors, genetic variability of the virus, and the host viral interplay. The challenge of medical science is the early diagnosis/identification of the potential for development of fatal complications like liver cirrhosis and HCC so that timely medical intervention can improve the chances of survival. Currently, neither the vaccination regime nor the diagnostic methods are completely effective as reflected in the high number of annual deaths. It is evident from numerous publications that microRNAs (miRNAs) are the critical regulators of gene expression and various cellular processes like proliferation, development, differentiation, apoptosis and tumorigenesis. Expressions of these diminutive RNAs are significantly affected in cancerous tissues as a result of numerous genomic and epigenetic modifications. Exosomes are membrane-derived vesicles (30–100 nm) secreted by normal as well as malignant cells, and are present in all body fluids. They are recognized as critical molecules in intercellular communication between cells through horizontal transfer of information via their cargo, which includes selective proteins, mRNAs and miRNAs. Exosomal miRNAs are transferred to recipient cells where they can regulate target gene expression. This provides an insight into the elementary biology of cancer progression and therefore the development of therapeutic approaches. This concise review outlines various on-going research on miRNA mediated regulation of HBV pathogenesis with special emphasis on association of exosomal miRNA in advanced stage liver disease like hepatocellular carcinoma. This review also discusses the possible use of exosomal miRNAs as biomarkers in the early detection of HCC and liver cirrhosis.
Development of a standardized method to evaluate the protective efficiency of cosmetic packaging against microbial contamination
Authors:   the members of the Cosmetic Valley EPMP commission, Catovic Chloe , Martin Sylvia , Desaint Stéphane , Borges Christine , Lesouhaitier Hélène , Roullet Florence , Bresciani Nadine , Jouault Anne-Marie , Poulet Valérie , Luc Joelle , Joulia Valérie , Jupin Alain , Masson Christophe , Crozier Alain , Feuilloley Marc G. J.
Published: April 2020

Doubts surrounding the potential adverse effects of antimicrobial preservatives have modified the demand of consumers, who increasingly insist on the production of low-level and even preservative-free cosmetics. Protection of the product against microbial contamination is therefore focused on the packaging. This has prompted the emergence of a highly diverse array of so-called “protective”, “overprotective”, and “barrier” packaging. However, these designations are not normalized and the choice of the right packaging adapted to each cosmetic product is still essentially empirical, hazardous, and time consuming. The Cosmetic Valleys cluster has launched a commission to define a complete and experimentally-validated method to classify the level of protection of cosmetic packaging against microbial contamination. As reported herein, this required the development a specific bacteriostatic medium that can be used for 7 days and an in vitro procedure that reproduces in-use contamination and consumer practices. Based on tests performed on over 800 packages of different origin and performance characteristics, we propose a classification, divided into six grades, to differentiate the protective efficiency of cosmetic packaging. This work can be considered as a first step towards a regulatory text.
Assessing the effectiveness of a comprehensive menstrual health intervention program in Ugandan schools (MENISCUS): process evaluation of a pilot intervention study
Authors: Nalugya Ruth , Tanton Clare , Hytti Laura , Kansiime Catherine , Nakuya Kevin , Namirembe Prossy , Nakalema Shamira , Neema Stella , Alezuyo Connie , Namuli Musoke Saidat , Torondel Belen , Francis Suzanna C. , Ross David A. , Bonell Chris , Seeley Janet , Weiss Helen A.
Published: April 2020

Background

Poor menstrual health and hygiene (MHH) is a globally recognised public health challenge. A pilot study of an MHH intervention was conducted in two secondary schools in Entebbe, Uganda, over 9 months. The intervention included five components delivered by the implementing partner (WoMena Uganda) and the research team: (i) training teachers to implement government guidelines for puberty education, (ii) a drama skit to reduce stigma about menstruation, (iii) training in use of a menstrual kit (including re-usable pads), (iv) guidance on pain relief methods including provision of analgesics and (v) improvements to school water, sanitation and hygiene (WASH) facilities. The aim of the process evaluation was to examine implementation, context and possible causal pathways.

Methods

We collected information on fidelity, dose, reach, acceptability, context and mechanisms of impact using (i) quantitative survey data collected from female and male students in year 2 of secondary school (ages 13–21; 450 at the baseline and 369 at endline); (ii) qualitative data from 40 in-depth interviews with parents, teachers and female students, and four focus group discussions with students, stratified by gender; (iii) data from unannounced visits checking on WASH facilities throughout the study; and (iv) routine data collected as part of the implementation. Quantitative data were used primarily to assess fidelity, dose and reach. Qualitative data were used primarily to assess acceptability, context and possible mechanisms.

Results

Both schools received all intervention elements that were delivered by the research team and implementing partner. The drama skit, menstrual kit and pain management intervention components were delivered with fidelity. Intervention components that relied on school ownership (puberty education training and WASH improvements) were not fully delivered. Overall, the intervention was acceptable to participants. Multilevel contextual factors including schools’ social and physical environment, and family, cultural and social factors influenced the acceptability of the intervention in the school setting. The intervention components reinforced one another, as suggested in our theoretical framework.

Conclusion

The intervention was feasible to deliver and acceptable to the schools and students. We propose a full-scale cluster-randomised trial to evaluate the intervention, adding a school-based MHH leadership group to address issues with school ownership.

Trial registration

ClinicalTrials.gov NCT04064736. Registered August 22, 2019, retrospectively registered.