bluuebunny/crossref_metadata_2025 huggingface dataset:
Lithospheric velocity structure from the southern North China Craton to the Qinling orogen: Constraints from Puyang-Nanyang wide-angle reflection/refraction sounding profiles
Authors: Yang Zhang , Tao Li , Honglin He , Liang Wang , Jiayi Gao , Shuaijun Wang , chengguang He
Published: August 2023

As a key study area of inter-plate interactions, continental-continental collision orogeny, and crust-mantle deformation mechanisms, the Central and Southern part of North China spans the North China Craton and the northern margin of the Qinling-Dabie orogen. However, our understanding of the present tectonic framework and deep dynamic process in this region lacks the constraints and support of the deep geophysical fine detection results. The Seismological Bureau of Henan Province set up the Puyang-Nanyng seismic wide-angle reflection/refraction profile with a length of about 550km, and constructed a two-dimensional crust-mantle fine velocity structure spanning the main tectonic units. The detection results show: (1) The study area has a three-layer structure: the upper crust, middle crust and lower crust. The thickness of the crust ranges from 32.0 to 36.0 km. The thickest part is the northern margin of the South Qinling (about 36 km) and the Taikang Uplift-Kaifeng Sag (35.2km); (2) There are three large lithospheric discontinuities in the upper mantle, corresponding to the Shangdan suture, the Luanchuan-Minggang fault, and the Xinxiang-Shangqiu fault, respectively. The crust-mantle velocity structure and tectonic form on both sides of the three faults/ suture have significant heterogeneity in the vertical and lateral directions, and the overall features of lateral fragmentation and vertical decoupling are non-uniform. This feature is related to the tectonic evolution process since the Mesozoic, and the destruction and reconstruction of the North China Craton by tectonic evolution; (3) Low-velocity anomalies are relatively developed in the crust of the Northen North China Basin and the northern part of Southern North China Basin in Henan Province, and the combination of high and low velocity anomaliesis easy to induce earthquakes, which makes the study area have a deep seismogenic background for moderate and strong earthquakes.
A technology-organization-environment (TOE) framework based on the scientific research directions for risk in sustainable water resources management
Authors: Lin ChihHsien , Chen Wei-Hsiang
Published: August 2023

The issue to study how water can be used in a way to meet sustainability through risk management has become increasingly complex given that many keywords in different aspects are involved. This study started with trend analysis, followed by bibliometric analysis, and eventually built a conceptual TOE framework. In the trend analysis, water conservation and water crisis were the top-mentioned words, suggesting the need to address the public concern for these issues. In the bibliometric analysis, 37% of the articles were published in the last three years, and environmental science and technology was the major field of the articles. An approach of a technology-organization-environment (TOE) framework was proposed to link and group the keywords from the articles, referred to as risks, in the categories of technology, organization, and environment. By calculating the score of each keyword in the categories to quantify their degree of impact, the three risks that had the highest scores were statistical analysis (belonged to the category of technology), climate change, and uncertainty (both belonged to the category of environment). In the category of technology, statistical analysis, sustainable development, and water quality represented the most important risks. As water management, governance, and water markets were critical in the category of organization, climate change, uncertainty, and flood represented the keys in the environment category. This study is expected to provide valuable information regarding the research trends important to achieve sustainability of water resource management in both conventional and academic studies in the last decade.
Application of artificial neural network to screen out the dominant meteorological parameters for prediction of air temperature
Authors: Kumar Ankit , Elumalai Suresh Pandian
Published: August 2023

The significant meteorological parameter, air temperature (TP), is often measured with limited spatial resolution, which necessitates the prediction of them at places far from monitoring stations and in the cases of accidentally missing data from the data loggers of monitoring stations. This study supports a non-location-specific model for air temperature prediction by combining a three-layer backpropagation artificial neural network (ANN) and meteorological data. The partial mutual information (PMI) algorithm & cross-correlation method incorporated with the ANN model reveals density altitude (DA), heat index (HI), relative humidity (RH), and wet bulb temperature (WB) as potential input variables for the prediction of TP. DA and HI are strongly correlated to TP for the whole year for all types of land covers whereas the dependency of TP on RH varies seasonally. RH is always a topping variable for air temperature prediction, which undoubtedly enhances the prediction accuracy. In pre-monsoon and monsoon, there are only three dominant input variables for the prediction of air temperature, i.e., DA, HI, and RH. In the post-monsoon, WB comes into role as an additional predictor. Using the predictor set of potential input variables, the prediction shows a good agreement between ANN-estimated air temperature and measured air temperature, i.e. the coefficient of determination of 99.46%, 99.23%, 99.73%, and 99.18% for pre-monsoon, monsoon, post-monsoon, and winter season, respectively. ANN modeling is a reliable method for predicting air temperature.
Coupling between substrate specificity and neutralisation mechanisms in toxic Small Alarmone Synthetases
Authors: Garcia-Pino Abel , Dominguez-Molina Lucia , Kurata Tatsuaki , Cepauskas Albinas , Echemendia-Blanco Dannele , Talavera Ariel , Atkinson Gemma , Hauryliuk Vasili
Published: August 2023

Toxic Small Alarmone Synthetase (toxSAS) enzymes constitute a family of bacterial effectors present in toxin-antitoxin (TA) and secretion systems. toxSASs act either through translation inhibition mediated by pyrophosphorylation of tRNA CCA-ends (exemplified by FaRel2) or through synthesis of the toxic alarmone (pp)pApp and ATP depletion (exemplified by FaRel). Both enzymatic reactions use ATP as the pyrophosphate donor. Here we show that the pseudo-Zn2+ finger domain (pZFD, equivalent to Panacea-Associated Domain 1, PAD1) of the ATfaRel2 antitoxin precludes access of ATP to the pyrophosphate donor site of the FaRel2 toxin, without affecting recruitment of the tRNA pyrophosphate acceptor. By contrast, (pp)pApp-producing toxSASs are inhibited by Tis1 antitoxin domains though occlusion of the pyrophosphate acceptor binding site. Consequently, the auxiliary pZFD of AT2faRel is dispensible for FaRel neutralisation. Collectively our study establishes the general principles of toxSAS inhibition by structured antitoxin domains, with the control strategy directly coupled to toxSAS substrate specificity.
Study on gas velocity distribution of gas-liquid stratified flow based on numerical simulation and PIV
Authors: Liu Xu , Zhao Danlei , Han Bangbang , Zhai Ke , Chen Xiao , Fang Lide
Published: August 2023

The velocity is an important parameter for the fluid flow characteristics in the two-phase flow. In the gas-liquid two-phase stratified flow, the most easily obvious force equilibrium point is at the peak point of the gas phase velocity. This study is of great significance for constructing the two-phase stratified flow model. In this paper, the flow field characteristics of the gas-liquid stratified flow are investigated by numerical simulation and a theoretical model of the gas phase peak velocity position is established. The accuracy of numerical simulation is illustrated by comparing classical prediction model and PIV experimental data. The results indicate that the position of gas-liquid interface moves down and the position of gas phase peak velocity moves up with an increase in gas mass flow rate. Conversely, when gas phase mass flow rate is constant, the position of gas-liquid interface moves up and the position of gas phase peak velocity moves down with an increase in liquid mass flow rate. By exploring the relationship between the position of the peak gas velocity point and ratio of the Reynolds number, it is found that the position of the gas peak velocity has a linear relationship with the gas-liquid Reynolds number. The multiple correlation coefficient is 0.85, obtained by linear regression fitting which stated that there is a strong linear relationship between the two variables.
A unified European hydrogen infrastructure planning to support the rapid scale-up of hydrogen production
Authors: Kountouris Ioannis , Bramstoft Rasmus , Madsen Theis , Gea-Bermúdez Juan , Münster Marie , Keles Dogan
Published: August 2023

Hydrogen will become a key player in the transition toward a net-zero energy system. However, a clear pathway toward a unified European hydrogen infrastructure is still under discussion. We explore plausible pathways using a fully sector-coupled energy system model and assess the emergence of hydrogen infrastructure build-outs connecting third-nation hydrogen import and domestic production centers with Western and Central European demands via four distinct hydrogen corridors. We identify a potential lock-in effect of blue hydrogen in the medium term, highlighting the risk of long-term dependence on methane. In contrast, we show that a self-sufficient Europe relying on domestic green hydrogen by 2050 increases yearly expense by around 3 % and requires 500 GW of electrolysis. This study emphasizes the importance of a rapid scale-up of electrolysis capacity, build-out of hydrogen network and storage facilities, deployment of renewable electricity generation, and coherent coordination across European nations.
From Answers to Insights: Unveiling the Strengths and Limitations of ChatGPT and Biomedical Knowledge Graphs
Authors: Hou Yu , Yeung Jeremy , Xu Hua , Su Chang , Wang Fei , Zhang Rui
Published: August 2023

Purpose:
Large Language Models (LLMs) have shown exceptional performance in various natural language processing tasks, benefiting from their language generation capabilities and ability to acquire knowledge from unstructured text. However, in the biomedical domain, LLMs face limitations that lead to inaccurate and inconsistent answers. Knowledge Graphs (KGs) have emerged as valuable resources for organizing structured information. Biomedical Knowledge Graphs (BKGs) have gained significant attention for managing diverse and large-scale biomedical knowledge. The objective of this study is to assess and compare the capabilities of ChatGPT and existing BKGs in question-answering, biomedical knowledge discovery, and reasoning tasks within the biomedical domain.
Methods:
We conducted a series of experiments to assess the performance of ChatGPT and the BKGs in various aspects of querying existing biomedical knowledge, knowledge discovery, and knowledge reasoning. Firstly, we tasked ChatGPT with answering questions sourced from the "Alternative Medicine" sub-category of Yahoo! Answers and recorded the responses. Additionally, we queried BKG to retrieve the relevant knowledge records corresponding to the questions and assessed them manually. In another experiment, we formulated a prediction scenario to assess ChatGPT's ability to suggest potential drug/dietary supplement repurposing candidates. Simultaneously, we utilized BKG to perform link prediction for the same task. The outcomes of ChatGPT and BKG were compared and analyzed. Furthermore, we evaluated ChatGPT and BKG's capabilities in establishing associations between pairs of proposed entities. This evaluation aimed to assess their reasoning abilities and the extent to which they can infer connections within the knowledge domain.
Results:
The results indicate that ChatGPT with GPT-4.0 outperforms both GPT-3.5 and BKGs in providing existing information. However, BKGs demonstrate higher reliability in terms of information accuracy. ChatGPT exhibits limitations in performing novel discoveries and reasoning, particularly in establishing structured links between entities compared to BKGs.
Conclusions:
To address the limitations observed, future research should focus on integrating LLMs and BKGs to leverage the strengths of both approaches. Such integration would optimize task performance and mitigate potential risks, leading to advancements in knowledge within the biomedical field and contributing to the overall well-being of individuals.
A class of cancellable L-algebras
Authors: Ruan Xianglong , Liu Xiaochuan
Published: August 2023

Given three $L$-algebras $X$, $Y$ and $Z$ such that $X \times Z$ is isomorphic to $Y \times Z$, when are $X$ and $Y$ isomorphic? In this paper we answer positively this question when $Z=Z_n$, where $Z_n$ is an n-elements $L$-algebra.
Influential Factors in Accepting Amputation by Trauma Patients: A qualitative study
Authors: Sousan Valizadeh , Hadi Hassankhani , Eissa Mohammadi , Molavi Zahra , Dadkhah Behrouz , Kheiri Roya
Published: August 2023

Background:Trauma is an influential factor in the occurrence of amputations. The impact of amputation on the spiritual and mental status of the individual and their family relationships is indisputable. Thus, we conducted the present study to determine the factors influencing the acceptance of amputation in trauma patients and assess the impact of these factors on their adaptability to their new circumstances and improvement of their quality of life (QOL).Methods:This qualitative study was grounded theory research. Using theoretical and purposive sampling, 20 individuals who had undergone lower limb amputation due to trauma were chosen as the study participants. The primary data collection method in the present study was an unstructured interview. The participants’ answers were recorded, transcribed verbatim, and statistically analyzed using the constant comparison method and qualitative content analysis.Results: The central theme extracted from the data was Accepting Amputation. The classes include “Positive Self-Hypnosis, “Realism, “Increasing Tolerance with Time, “Self-Esteem and Correcting Body Image, “and " Emergence of Glimmers of Hope, “Conclusion:Amputation affects all aspects of an individual’s life and causes physical, spiritual, mental, and social problems, and thus, the identification and reinforcement of the factors influential on the acceptance of the illness can be effective on the adaptability of these individuals to their new circumstances and improvement of their QOL.
Closed simple geodesics on a polyhedron
Authors: Protasov Vladimir
Published: August 2023

It is well-known that every isosceles tetrahedron (disphenoid) admits infinitely many simple closed geodesics on its surface. They can be naturally enumerated by pairs of coprime integers n > m > 1 with two additional cases (1, 0) and (1, 1). The (n, m)- geodesic is a broken line with 4(n+ m) vertices, its length tends to infinity as m → ∞. Are there other polyhedra possessing this property? The answer depends on convexity. We give an elementary proof that among convex polyhedra only disphenoids admit arbitrarily long closed simple geodesics. For non-convex polyhedra, this is not true. We present a counterexample with the corresponding polyhedron being a union of seven equal cubes. Several open problems are formulated.
Coverage for evidence-based cancer survivorship care services
Authors: Blaes Anne H. , Abu-Khalaf Maysa M. , Bender Catherine M. , Dent Susan F. , Fung Chunkit , Smith Sophia K. , Watson Samantha , Katta Sweatha , Merrill Janette K. , Hudson Shawna V.
Published: August 2023

Purpose
The American Society of Clinical Oncology Cancer Survivorship Committee established a task force to determine which survivorship care services were being denied by public and private payers for coverage and reimbursement.
Methods
A quantitative survey instrument was developed to determine the clinical practice-reported rates of coverage denials for evidence-based cancer survivorship care services. Additionally, qualitative interviews were conducted to understand whether coverage denials were based on payer policies, cost-sharing, or prior authorization.
Results
Of 122 respondents from 50 states, respondents reported that coverage denials were common (“always”, “most of the time,” or “some of the time”) for maintenance therapies, screening for new primary cancers or cancer recurrence. Respondents reported that denials in coverage for maintenance therapies were highest for immunotherapy (41.74%) and maintenance chemotherapy (40.17%). Coverage denials for new primary cancer screenings were highest for Hodgkin lymphoma survivors needing a PET/CT scan (49.04%) and breast cancer survivors at a high-risk of recurrence who needed an MRI (63.46%), respectively. More than half of survey respondents reported denials for symptom management and supportive care services. Fertility services, dental services when indicated, and mental health services were denied “always” or “most of the time” 23.1%, 22.5%, and 12.8%, respectively. Respondents reported they often had a process in place to automatically appeal denials for evidence-based services. The denial process, however, resulted in greater stress for the patient and provider.
Conclusion
Our study demonstrates that additional advocacy with payers is needed to ensure that reimbursement policies are consistent with evidence-based survivorship care services.
Proteome profiling of Enriched Membrane-associated Proteins Unraveled a Novel Sophorose and cello-oligosaccharide Transporter in Trichoderma reesei
Authors: Nogueira Karoline Maria Vieira , Kamath Karthik Shantharam , Cheruku Anusha , Oshiquiri Letícia Harumi , de Paula Renato Graciano , Carraro Claudia , Pedersoli Wellington Ramos , Vieira Luiz Carlos , Steindorff Andrei Stecca , Amirkhani Ardeshir , McKay Matthew J. , Nevalainen Helena , Molloy Mark P. , Silva Roberto N. , Mendes Vanessa
Published: August 2023

Background
Trichoderma reesei is an organism extensively used in the bioethanol industry, owing to its capability to produce enzymes capable of breakdown holocellulose into simple sugars. The uptake of carbohydrates generated from cellulose breakdown is crucial to induce the signaling cascade that triggers cellulase production. However, the sugar transporters involved in this process in T. reesei remain poorly identified and characterized.
Results
To address this gap, this study used temporal membrane proteomics analysis to identify five known and nine putative sugar transporters that may be involved in cellulose degradation by T. reesei. Docking analysis pointed out potential ligands for the putative sugar transporter Tr44175. Further functional validation of this transporter was carried out in Saccharomyces cerevisiae. The results showed that Tr44175 transports a variety of sugar molecules, including cellobiose, cellotriose, cellotetraose, and sophorose.
Conclusion
This study has unveiled a transporter Tr44175 capable of transporting cellobiose, cellotriose, cellotetraose, and sophorose. Our study represents the first inventory of T. reesei sugar transportome once exposed to cellulose. This work will contribute to bioethanol production from cellulosic biomass.
Assessing Motivation for Treatment in Eating Disorders: Psychometric Validation of the Italian Version of the Autonomous and Controlled Motivation for Treatment Questionnaire (ACMTQ-ITA)
Authors: Tempia Valenta Silvia , Rapezzi Matilde , Marcolini Federica , Speciani Maurizio , Giordani Gabriele , De Ronchi Diana , Atti Anna Rita
Published: August 2023

Purpose.
Treatment resistance is a significant challenge in addressing eating disorders (EDs). The Autonomous and Controlled Motivation for Treatment Questionnaire (ACMTQ) has been previously validated in ED populations to assess patients' motivation for treatment. The objective of this study was to validate the ACMTQ in the Italian language (ACMTQ-ITA) and evaluate its psychometric properties.
Methods.
A clinical sample comprising 81 adults (aged 18–65 years) diagnosed with EDs, possessing a good understanding of the Italian language, and providing written informed consent, was recruited. Individuals with psychiatric comorbidities such as schizophrenia, substance use disorder, and bipolar disorder were excluded. Construct validity and internal consistency of the ACMTQ-ITA were assessed using the Kaiser-Meyer-Olkin (KMO) test, Bartlett's test of sphericity, Exploratory Factor Analyses (EFA), reliability analysis with Cronbach's α estimates, and Confirmatory Factor Analysis (CFA).
Results.
EFA confirmed the existence of a two-factor structure akin to the original validation, comprising Autonomous Motivation (Factor 1; α = 0.81) and Controlled Motivation (Factor 2; α = 0.79). The internal consistency of the ACMTQ-ITA overall score was found to be satisfactory (α = 0.79) through reliability analysis. Furthermore, CFA demonstrated an acceptable fit to our hypothesized model (comparative fit index = 0.90, root mean square error of approximation = 0.09, standardized root mean square residual = 0.10).
Conclusion.
The ACMTQ-ITA emerged as a valid and reliable tool for measuring motivation for treatment in individuals with EDs. Its implementation may facilitate the comprehension of treatment motivation, offering valuable clinical insights and implications for health management practices.
The impact of biologic treatment in psoriasis patients on COVID-19 infection: A single-center retrospective study
Authors: Gu Zheng , Zhang Xiaoyan , Li Zongyang , Wang Huijing
Published: August 2023

Previous studies of whether biologics place psoriasis patients at more severe SARS-CoV-2 infection risk and disease course remains unclear.This single-center retrospective clinical study included patients with psoriasis from December 2022 to April 2023 to compare the rate of COVID-19 infection, duration, and risk of hospitalization and death in patients treated with to without biologics,and to compare the effect of COVID-19 on the course of psoriasis. General information, underlying diseases, disease information of psoriasis and covid-19 infection were recorded. SPSS 28.0 was used for statistical analysis of the data. Among the 260 included patients with psoriasis, 73.85% were treated with biologics. 67.31% of patients were infected with COVID-19.The mean duration of symptoms was 7.57±4.75 days. No patients were counted as requiring oxygenation or hospitalization for SARS-CoV-2 infection. No deaths were recorded during the observation period.The amount of patients with fever was lower in patients treated with biologics(81.20%) compared to those without one(97.62%). Differences in the distribution of other COVID-19-specific signs and symptoms were not statistically significant(P＜0.05). Binary logistic regression suggested that increased prevalence was not associated with the use of biologics after adjustment for potential confounders (OR=0.672,P=0.198). 38.86% of patients had exacerbation of psoriatic lesions after infection with SARS-CoV-2, with a statistically significant difference between those with and without biologics. Exacerbation was more common in the form of a new rash. The finding suggests biologics in patients with psoriasis does not increase the risk of SARS-CoV-2 infection or worsen the course of COVID-19. In terms of exacerbation of psoriatic lesions by SARS-CoV-2 infections, the number of worsening disease courses treated with biologics was lower compared to conventional treatments.
pulmonary blastoma with good prognosis: a case report and review of the literature
Authors: LIU RU , Li Fengchao , Wang Lulu , Lv Feng , Yin Qianqian , Liu Guangzhen , Chen Wen
Published: August 2023

Background:Pulmonary blastoma (PB) is a rare, highly malignant tumor prone to distant metastasis and recurrence, and the prognosis of patients is often poor. Here, we reported a case of metastatic PB with good prognosis, to provide data support for clinical diagnosis and treatment.Methods and results:In December 2015, a 43-year-old male patient was admitted to our hospital.PET-CT showed massive high-density imaging in the lower lobe of the right lung, with a maximum cross-section of about 76mm×58mm, and increased FDG metabolism development (SUVmax: 13.8g/mL). After completing the relevant examination, thoracoscopic assisted right lower lobectomy with lymph node dissection was performed. The postoperative pathological diagnosis was PB, and epithelial components and mesenchymal differentiation components were both observed in tumor tissues. One month after surgery, chest CT revealed a right pleural effusion and multiple nodules in the left lung, which suggested a high possibility of metastasis. Then the patient received docetaxel and cisplatin chemotherapy for a total of 6 courses. After chemotherapy, CT showed significant absorption of pleural effusion, and the left lobe pulmonary nodule was not detected. The patients were followed up closely within 7 years after surgery. Up to now, no signs of recurrence or distant metastasis have been found.Conclusion:We report an unusual case of metastaticPB that showed a significant therapeutic response to docetaxel and cisplatin. Surgical resection and postoperative chemotherapy may be the preferred treatment.
Effect of H3BO3 modification on the char yield of epoxy resin and pore structure and property of epoxy resin carbon foams
Authors: YANG Ping Jun , LI Tie Hu , LI Hao , DANG A Lei
Published: August 2023

H3BO3 promotes the removing oxygen-containing functional groups of epoxy resin (EP) and forms B-O-C bond with EP. The char yield of EP increases first and then decreases with H3BO3 content increasing, which is 33.4 wt% and 19 wt% for 9 wt% H3BO3 modified EP and EP. The graphitization degree (g) and grain stacking thickness (Lc) of EP carbon foam (CF) first decrease and then increase with H3BO3 increase. The graphitization degree (g) of 3, 6, 9 and 12 wt% H3BO3 modified EP CF are 11.6, 0, 0, and 23.2%. The ID/IG value of 0, 3, 6, 9, 12 wt% H3BO3 modified EP CF are 0.97, 1.05, 1, 1.1, and 0.89. For low H3BO3 content (0, 3 wt%), the small bubbles combined easily, and led to bigger bubble size. When the H3BO3 content was high (above 6 wt%), the combination of small bubbles becomes more difficult, and decreases cell size. The cell sizes of 0, 6, 12 wt% H3BO3 modified EP CF are 620 µm, 440 µm, 760 µm, respectively. When the H3BO3 varies from 0 and 3 wt%, the electrical conductivity of modified EP CF increased from 15.56 to 25.94 S/m. The compressive strength of the H3BO3 modified EP CF gradually decreased with increase of H3BO3 from 0 to 12 wt%, which can be influenced by its density. The compressive strength of 12 wt% H3BO3 modified EP CF is only 0.6 Mpa, which is much lower than the EP CF (3.32 MPa).
Numerical Inference on the Generalized Weibull
Model Parameters Using Picard’s Method
Authors: Maswadah M.
Published: August 2023

In this study, numerical analysis has been used to introduce an optimal estimation method, Picard’s method, which outperforms the Bayes’ method. To clarify that, the point estimates for the generalized Weibull model parameters were derived using this method and compared with the Bayes’ method based on the informative gamma prior, kernel prior and characteristic prior, via Monte Carlo simulation based on the generalized progressive hybrid censoring scheme. The simulation results indicated that Picard’s method is highly efficient and outperforms the Bayes’ method. Finally, two real datasets were studied to ensure Picard’s method can be used more effectively than the most popular estimation methods in fitting and analyzing real-life data.
Security issues of cyber-physical systems
Authors:   Reshetnev Siberian State University of Science and Technology (SibSU), Kushko Evgenij A. , Grachyov Dmitrij A. ,   Reshetnev Siberian State University of Science and Technology (SibSU), Parotkin Nikolaj Y. ,   Reshetnev Siberian State University of Science and Technology (SibSU), Zolotaryov Vyacheslav V. ,   Reshetnev Siberian State University of Science and Technology (SibSU)
Published: August 2023

Cyber-physical systems are increasingly being used in all industries. However, as the distribution of these systems grows, the number of attacks on them increases. The paper covers main cyber- hysical systems building technologies, implemented security measures, advantages, disadvantages and vulnerabilities of such systems. The authors also provide a general approach to ensuring cyber- hysical systems security.
Multivariate regression model to assess the qualifications of a software tester
Authors:   Novosibirsk State Technical University (NSTU), Gavriliev Erchimen I. , Avdeenko Tatiana V. ,   Novosibirsk State Technical University (NSTU)
Published: August 2023

The competence of testers and their professional development are important aspects of IT-project’s success. Companies’management evaluates periodically the employees’ qualifications in order to identify potential areas for career growth. However, the assessment is frequently based on managers’ subjective opinions and may negatively affect employees’ further professional development. The purpose of this work is to develop a regression model for assessing the qualifications of software testers. The proposed model uses data from information systems that testers use in their daily work. To collect information and carry out calculations, a decision support system was developed, that was implemented in a company developing software for the banking industry. Building a regression model made it possible to identify the main factors influencing the professional knowledge and skills of a tester.
Control of nonlinear dynamic processes of three-phase regenerative converters with space-vector modulation
Authors:   Bryansk State Technical University, Andriyanov Alexey I. , Baranchikov Maksim V. ,   Bryansk State Technical University
Published: August 2023

A control system for nonlinear dynamic processes of threephase regenerative converters is considered. The system is built on the basis of the target-oriented control and allows to provide the desired dynamic mode without additional parametric synthesis. It eliminates the contradiction between the requirements for the switching frequency or the parameters of the transient process in the system and the requirements for the desired dynamic mode when the system parameters change over a wide range. A control system for nonlinear dynamic processes based on the method of directing to the purpose is proposed, that allows solving the specified problem. When implementing the system under consideration, it is assumed to evaluate the coordinates of fixed points of the desired mode based on measurements on a real control object with subsequent digital processing of the received signals in order to isolate the main harmonics. The simulation of the considered system and the efficiency of the proposed control system for nonlinear dynamic processes are performed. The proposed approach can be applied in other power conversion systems with low- frequency periodic impacts in conditions of lowfrequency distortion of the shape of currents or voltage as a result of bifurcations.
Synthesis of broadband differential phase shifters on electromagnetically coupled lines for multibeam antenna arrays
Authors:   Novosibirsk State Technical University (NSTU), Gorbachev Anatoly P. , Parshin Yury N. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: August 2023

The work is devoted to the synthesis of differential phase shifters on electromagnetically coupled lines with a closed ring conductor. In comparison with the known phase shifters, the proposed structure is characterized by additional degrees of freedom in printed strip design and provides the possibility of designing multipath equidistant phased antenna arrays with operating frequency bands up to one and a half octaves, provided that the emitters of their antenna canvases are characterized by the same broadband, for example, printed logoperiodic emitters. With narrow-band emitters, the possibility of implementing a dual-frequency or multi-frequency mode of operation of a multipath antenna array opens up.
Study of a single-wave rectifier with capacitive load
Authors:   Komsomolsk-na-Amure State University, Frolov Aleksey V. , Grunina Nadezhda Y. ,   Komsomolsk-na-Amure State University
Published: August 2023

The article presents the results of theoretical calculations and SimInTech program simulation of a function of a single-phase single-wave rectifier with a capacitive filter and an active load. The correlation between the average load voltage, the minimum load voltage, the ripple factor and the RC load constant are given. The article shows that the available in literature approximating dependences of the load voltage characteristics do not correspond to either the results of theoretical calculations or the results of mathematical modeling. The found dependences allow to produce the optimal value of the smoothing filter capacitance for the desired load.
Development of a scalable small-signal 0.1 µm GaAs-pHEMT-model for amplifier applications
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Dobush Igor M. , Dudinov Konstantin V. ,   Istok JSC, Zykov Dmitry D. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Salnikov Andrei S. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Popov Artem A. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Emelyanov Artem M. ,   Istok JSC, Bragin Dmitry S. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Khayrov Damir R. ,   Development, Semiconductor Design and Technology Center LLC
Published: August 2023

This work deals with the development of a 0.1-µm GaAspHEMT-model for use in EDA applications. The model is constructed using a reference transistor with a total gate width of 635 μm, which showed good accuracy under different DC operation modes in a wide frequency range. The developed model can be used to speed up and reduce the cost of the monolithic microwave integrated circuit amplifiers design in which the pHEMT transistor is the basic active element. In further studies the obtained model will be extended to develop more complex types of models, such as noise and nonlinear ones.
Extending coverage area in none line-of-sight MIMO communications using passive repeaters
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Eissa Mahmoud , Sukhanov Dmitry Y. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: August 2023

In MIMO communications, high buildings in cities and other obstructions can prevent the propagation of radio waves, resulting in blind spots and poor communications. This problem can be solved using passive repeaters, which, by distributing them in the communication environment, the blind spots can be accessed and the coverage area can be extended. The distribution of these repeaters in the MIMO communication should be optimized in order to maximally cover the target area. In this article, an approach based on non-negative least square (NNLS) algorithm is proposed for optimizing the distribution of the minimum number of repeaters in none-line-of sight (NLOS) MIMO communications. The proposed approach is implemented using passive repeaters consisting of two parabolic antennas connected through a flexible cable. The numerical analysis is performed to verify the validity of the proposed approach, and it is found that the proposed method helps to optimally distribute passive repeaters and extend coverage area with minimum number of repeaters.
Information systems for national security threat analysis
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Popov Konstantin V. , Shelupanova Polina A. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: August 2023

Information technology plays a significant role in what has become known as «computational social science». The development of online technologies and digital research methods in the subject areas of social science is associated with the application of new interdisciplinary approaches and the integration of researchers from different fields of knowledge. As an effective and promising tool for researchers in the study of violent ideologies that destabilize the social order, the article discusses examples of databases, services and platforms for multivariate analysis. Opportunities and imitations of customizing data collection, processing, and presentation are outlined. An overview of the specific characteristics of the databases, services and platforms on the START Research Center website is presented. Conclusions are made about what opportunities such tools open for researchers and the prospects of realization of the most interesting solutions for improving the process of automation of data analysis are outlined.
New Mineral Names
Authors: Celestian Aaron J.
Published: August 2023

This issue of New Mineral Names provides a summary of the newly described minerals donowensite, mikehowardite, bortolanite, fluorsigaiite, alumolukrahnite, ferro-ferri-katophorite, tomsquarryite, and argentotetrahedrite-(Zn).
The classical Heisenberg model on the centred pyrochlore lattice
Authors: Nutakki Rajah P. , Jaubert Ludovic D. C. , Pollet Lode
Published: August 2023

The centred pyrochlore lattice is a novel geometrically frustrated lattice, realized in the metal-organic framework Mn(ta)_22 [Phys. Rev. Research 5, L022018 (2023)] where the basic unit of spins is a five site centred tetrahedron. Here, we present an in-depth theoretical study of the J_1-J_2J1−J2 classical Heisenberg model on this lattice, using a combination of mean-field analytical methods and Monte Carlo simulations. We find a rich phase diagram with low temperature states exhibiting ferrimagnetic order, partial ordering, and a highly degenerate spin liquid with distinct regimes of low temperature correlations. We discuss in detail how the regime displaying broadened pinch points in its spin structure factor is consistent with an effective description in terms of a fluid of interacting charges. We also show how this picture holds in two dimensions on the analogous centred kagome lattice and elucidate the connection to the physics of thin films in (d+1d+1) dimensions. Furthermore, we show that a Coulomb phase can be stabilized on the centred pyrochlore lattice by the addition of further neighbour couplings. This demonstrates the centred pyrochlore lattice is an experimentally relevant geometry which naturally hosts emergent gauge fields in the presence of charges at low energies.
Inferring nuclear structure from heavy isobar collisions using Trajectum
Authors: Nijs Govert , van der Schee Wilke
Published: August 2023

Nuclei with equal number of baryons but varying proton number (isobars) have many commonalities, but differ in both electric charge and nuclear structure. Relativistic collisions of such isobars provide unique opportunities to study the variation of the magnetic field, provided the nuclear structure is well understood. In this work we simulate collisions using several state-of-the-art parametrizations of the ^{96}_{40}4096Zr and ^{96}_{44}4496Ru isobars and show that a comparison with the exciting STAR measurement [arXiv:2109.00131] of ultrarelativistic collisions can uniquely identify the structure of both isobars. This not only provides an urgently needed understanding of the structure of the Zirconium and Ruthenium isobars, but also paves the way for more detailed studies of nuclear structure using relativistic heavy ion collisions.
Directors’ Views on Adapted Physical Education and Sports Practices in Special Education and Rehabilitation Centers
Authors: KARAKAŞ Gizem , YILMAZ Atike
Published: August 2023

Introduction: This study aimed to determine the current situation regarding physical education and sports practices for special needs students in special education and rehabilitation centers and to analyze the views of the directors of these institutions in detail.
Method: The case study design used for qualitative research was employed. The research was conducted in nine institutions operating in the Izmit district of Kocaeli province, Turkey, via selection through easily accessible case sampling. The directors of the institutions were interviewed individually following semi-structured interview forms. The data obtained were analyzed using the content analysis method.
Findings: In line with the opinions expressed by the participants, four main themes and ten sub-themes emerged. The main themes identified were the shadow of the Ministry of National Education, educator characteristics, guidance toward physical education and sports, and integrity of development.
Discussion: Although there are no official guidelines for physical education and sports, services and guidance pertaining to physical education and sports exist thanks to the sensitivity and efforts of the institutions. The participating directors revealed the desire to add a module in physical education and sports to the regulations, and they are committed to fulfilling the relevant requirements. For the directors of the institutions, who undertake their efforts in the shadow of the regulations and are aware of the benefits that sports practices will provide to children with special needs, using their initiative and whatever financial and moral means are at their disposal are viewed as necessary steps to be taken in the name of education. Within this context, physical education and sports teachers and recreation leader should also be included and employed as personnel in such institutions, a condition that should be considered mandatory in the Special Education Institutions Regulation of the Ministry of National Education.
Characterizing the hydraulic conductivity of soil based on the moving average of precipitation and groundwater level using a regional database
Authors: Kim Bokyung , Roh Gyeomju , Lee Jiyeong , Yoon Jonghyeog , Lee Junhwan
Published: August 2023

Hydraulic conductivity is an important geological and geotechnical characteristic, necessary for flow-related problems and underground construction. In many countries, databases for hydrology parameters and groundwater level (GWL) are well established, often not fully utilized for directly estimating hydraulic conductivity characteristics. In this study, a method for estimating hydraulic conductivity based on a regionally established database of hydrological, geological, and geotechnical parameters is proposed. For this purpose, 68 databases of hydrological, geological and geotechnical parameters in different regions in Korea were collected and adopted to develop a data-based estimation method of soil hydraulic conductivity. The time response of GWL to precipitation was considered as a key influence factor on the hydraulic conductivity of soil, as it directly affected the infiltration process of rainfalls into soil deposits. Moving average (MA) of precipitation was introduced, which gave the best correlation to GWL, to account for the effect of accumulated precedent precipitation. Case examples were selected and used to check the validity of the proposed method.
Inclusão digital na educação superior
Authors: Müller Adauton Ezequiel , Cecchin Andréa Forgiarini , Nogueira Vanessa dos Santos
Published: August 2023

Este artigo apresenta um recorte da pesquisa intitulada “Assistência Estudantil e Inclusão Digital: um estudo sobre as ações na UFSM”, vinculada ao Programa de Pós-graduação em Políticas Públicas e Gestão Educacional, da Universidade Federal de Santa Maria. Objetiva discutir a relevância das ações de inclusão digital e seus desdobramentos frente às desigualdades social, educacional e digital no contexto da Assistência Estudantil. A partir de revisão de literatura, verifica-se que a Assistência Estudantil é uma política pública que oportuniza condições para a permanência dos estudantes na educação superior pública e tem potencializado modificações em relação à desigualdade de oportunidades de acesso, permanência e conclusão dos cursos. Entretanto, sinaliza a complexidade e a necessidade de promoção de ações nos diversos eixos do Programa Nacional de Assistência Estudantil e a sua articulação com outras ações da universidade. Na perspectiva da inclusão digital, evidencia a necessidade de um maior debate e priorização pelas instituições.
Evaluation of Therapeutic Mechanism of Hedyotis Diffusa Willd (HDW)‒
Scutellaria Barbata (SB) in Clear Cell Renal Cell Carcinoma via Singlecell
RNA Sequencing and Network Pharmacology
Authors: Bai Yangyang , Chen Ruiting , Sun Jijian , Guo Yilin
Published: August 2023

Objective:

The present study aimed to investigate the therapeutic mechanism of Hedyotis
diffusa Willd (HDW) and Scutellaria barbata (SB) in ccRCC using a combination of single-cell
RNA sequencing (scRNA-seq) and network pharmacology.

Methods:

The active ingredients and potential molecular targets of HDW-SB were obtained from
the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. Gene
expression data (GSE53757) were obtained from the Gene Expression Omnibus database. The hub
genes of HDW-SB against ccRCC were identified via the protein–protein interaction network, and
further analyzed by molecular complex detection. The roles of these genes in the diagnosis and
immune infiltration of ccRCC were analyzed. The clinical significance of hub genes was verified
using scRNA-seq data (GSE121638) and molecular docking.

Results:

Following the PPI network analysis, 29 hub genes of HDW-SB against ccRCC were identified.
All hub genes, except for CENPE, had significantly different expressions in tumor tissue and
a more accurate diagnosis of ccRCC. Fifteen cell clusters were defined based on the scRNA-seq
dataset, and the clusters were annotated as six cell types using marker genes. TYMS and KIAA0101
from hub genes were highly expressed in NK cells. Three active compounds, quercetin, luteolin,
and baicalein, were found to target TYMS and KIAA0101 from the compound-target interaction
network.

Conclusion:

29 hub genes of HDW-SB against ccRCC were identified and showed good performance
in terms of diagnosis and prognosis. Moreover, among these hub genes docking with the
main ingredients of HDW-SB, TYMS and KIAA0101 exerted anti-ccRCC effects through NK cells.
Elucidation of the Role of the Epigenetic Regulatory Mechanisms of
PI3K/Akt/mTOR Signaling Pathway in Human Malignancies
Authors: Mohite Rupali , Doshi Gaurav
Published: August 2023

The PI3K/Akt/mTOR pathway modulates cell growth, proliferation, metabolism, and
movement. Moreover, significant studies have shown that the genes involved in this pathway are
frequently activated in human cancer. Observational and computational modeling of the PI3K/AKt/
mTOR pathway inhibitors has been explored in clinical trials. It has been observed that the effectiveness
and safety evidence from clinical studies and various inhibitors of this route have been given
FDA approval. In this review article, we focused on the processes behind the overactivation of
PI3K/Akt/mTOR signaling in cancer and provided an overview of PI3K/Akt/mTOR inhibitors as
either individual drugs or a combination of different doses of drugs for different types of cancer.
Furthermore, the review discusses the biological function and activation of the PI3K/AKt/mTOR
signaling and their role in the development of cancers. Additionally, we discussed the potential
challenges and corresponding prediction biomarkers of response and resistance for PI3K/Akt/m-
TOR inhibitor development. The article focuses on the most current breakthroughs in using the
PI3K/Akt/mTOR pathway to target certain molecules.