bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficient and Fast Removal of Aqueous Tungstate by an Iron-Based LDH Delaminated in L-Asparagine
Authors: Cao Yaowu , Guo Qinghai , Sun Weihao , Chelnokov Georgii A.
Published: June 2022

High concentrations of tungstate in aqueous systems pose a severe threat to the environment and human health. This study explored the potential of iron-based LDHs to remove tungstate from water. To improve its tungstate uptake capacity, environment-friendly L-asparagine was used to delaminate iron-based LDH synthesized via a coprecipitation method. The successful delamination was proved by AFM, revealing that the thickness of the obtained nanoparticles was approximately 1–2 times that of a single LDH layer. XRD, TEM, and XPS analyses confirmed that the delaminated LDHs were amorphous and ultrathin and had surface defects within their nanosheets that acted as active sites, leading to a very fast tungstate sorption rate and superior tungstate uptake capacity. Notably, the original layered structure of the L-asparagine-treated LDH was recovered upon its reaction with tungstate-bearing solutions, and therefore, the high availability of aqueous tungstate to the interlayer regions during the structural restoration of the delaminated iron-based LDH contributed to its excellent capability of tungstate removal as well. In addition, the tungstate uptake by the delaminated iron-based LDH was not affected substantially by the presence of coexisting anions, implying that the strong inner-sphere complexation between the tungstate and LDH layers with defects (i.e., Fe-O bonds) was the primary mechanism responsible for the tungstate removal. The delamination process described in this paper was validated to be an effective way to enhance the immobilization of tungstate by iron-based LDHs without inducing secondary pollutions, and delaminated iron-based LDHs are promising to be used extensively in the practice of treating tungstate-rich waters.
Amelioration of Coastal Salt-Affected Soils with Biochar, Acid Modified Biochar and Wood Vinegar: Enhanced Nutrient Availability and Bacterial Community Modulation
Authors: Wang Zhangjun , Pan Xin , Kuang Shaoping , Chen Chao , Wang Xiufen , Xu Jie , Li Xianxin , Li Hui , Zhuang Quanfeng , Zhang Feng , Wang Xiao
Published: June 2022

As an important part of the ecological environment, degraded coastal soils urgently require efficient and eco-friendly soil amendment. Biochar and wood vinegar have been proved to be effective soil amendments, and acid-modified biochar has great potential in ameliorating the degraded coastal saline–alkali soil. However, the effects of individual or combined application of biochar (BC), acid-modified biochar (ABC), and wood vinegar (WV) on coastal saline–alkali soil are unknown. Hence, biochar, wood vinegar, and acid-modified biochar were prepared by pyrolysis of poplar wood. The properties of biochar were characterized, and soil incubation experiments were conducted. The results showed that ABC decreased the soil alkalinity by acid-base neutralization and improved the soil fertility by increasing the nutrients (C, N, P). ABC provided a more suitable environment and changed the abundance and diversity of soil microorganisms. ABC increased the relative contents of specific families (e.g., Pseudomonadaceae and Sphingomonadaceae), which had strong ecological linkages in the C, N, and P cycles and organic matter degradation. The results indicated that WV had little effect on coastal saline–alkali soil, whereas individual and combined application of biochar (especially ABC) showed an efficient remediation effect. Our preliminary study demonstrated that the ABC could be a suitable solution for ameliorating degraded coastal saline–alkali soils.
Reclaiming Land, Identity and Mental Wellness in Biigtigong Nishnaabeg Territory
Authors: Nightingale Elana , Richmond Chantelle
Published: June 2022

Indigenous peoples globally are pursuing diverse strategies to foster mental, emotional, and spiritual wellness by reclaiming and restoring their relationships to land. For Anishinaabe communities, the land is the source of local knowledge systems that sustain identities and foster mino-bimaadiziwin, that is, living in a good and healthy way. In July 2019, the community of Biigtigong Nishnaabeg in Ontario, Canada hosted a week-long land camp to reclaim Mountain Lake and reconnect Elders, youth and band staff to the land, history, and relationships of this place. Framed theoretically by environmental repossession, we explore the perceptions of 15 participating community members and examine local and intergenerational meanings of the camp for mental wellness. The findings show that the Mountain Lake camp strengthened social relationships, supported the sharing and practice of Anishinaabe knowledge, and fostered community pride in ways that reinforced the community’s Anishinaabe identity. By exploring the links between land reclamation, identity, and community empowerment, we suggest environmental repossession as a useful concept for understanding how land reconnection and self-determination can support Indigenous mental wellness.
Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort
Authors: Wełnicki Marcin , Gorczyca-Głowacka Iwona , Lubas Arkadiusz , Wójcik Wiktor , Jelonek Olga , Maciorowska Małgorzata , Uziębło-Życzkowska Beata , Wójcik Maciej , Błaszczyk Robert , Rajtar-Salwa Renata , Tokarek Tomasz , Bil Jacek , Wojewódzki Michał , Szpotowicz Anna , Krzciuk Małgorzata , Gawałko Monika , Kapłon-Cieślicka Agnieszka , Tomaszuk-Kazberuk Anna , Szyszkowska Anna , Bednarski Janusz , Bakuła-Ostalska Elwira , Wożakowska-Kapłon Beata , Mamcarz Artur
Published: June 2022

Hyperuricemia is associated with the risk of developing atrial fibrillation (AF) and heart failure. However, coexisting chronic kidney disease and certain cardiovascular drugs make it difficult to determine whether hyperuricemia is a risk factor or merely a marker of pathology. We retrieved data from the Polish Atrial Fibrillation (POL-AF) registry, which included consecutive patients hospitalized with AF from January to December, 2019. We included 829 patients (mean age: 72.7 ± 11.1 years) with data on serum uric acid (UA, mean: 6.56 ± 1.78 mg/dL) and estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2. We found that UA and ejection fraction (EF) were significantly correlated (r = −0.15, p < 0.05), but not EF and eGFR or eGFR and UA. A multiple regression analysis adjusted for age, body mass index, eGFR, and UA, showed that UA was significantly associated with a reduced EF (R2: 0.021; p < 0.001). The UA cut-off indicative of an EF < 40% was 6.69 mg/dL (AUC, area under the curve: 0.607; 95% CI: 0.554–0.660; p = 0.001). Among drugs known to effect UA concentrations, we found that only diuretics were used more frequently in patients with high UA (above the median) than in patients with low UA (77.5% vs. 67%, p < 0.001). Among patients that used diuretics, UA remained significantly correlated with EF. Thus, we showed that reduced EF was associated with UA in patients with AF and normal renal function, independent of eGFR and diuretic use.
Relationships between Perceived Discrimination and Suicidal Ideation among Impoverished Chinese College Students: The Mediating Roles of Social Support and Loneliness
Authors: Mao Yanxia , Liu Luming , Lu Zi’ang , Wang Wenchao
Published: June 2022

We explored the mediating effect of social support and loneliness in the relationships between perceived discrimination and suicidal ideation among impoverished Chinese college students. Using the convenience cluster sampling method, we chose a total of 964 impoverished college students from a central province of China. Students completed the cross-sectional survey using the Perceived Discrimination Questionnaire, the Social Support Rating Scale, the University of California at Los Angeles Loneliness Scale, and the Beck Scale for Suicidal Ideation. Correlation analysis and structural equation modeling analysis were conducted to clarify the relationships between study variables. Correlation analysis showed that perceived discrimination, loneliness, and suicidal ideation were positively correlated with each other; social support was negatively correlated with perceived discrimination, loneliness, and suicidal ideation. In addition, structural equation modeling analysis indicated that perceived discrimination had a direct positive effect on suicidal ideation; social support and loneliness partially mediated the relationship between perceived discrimination and suicidal ideation. Specifically, perceived discrimination was positively associated with suicidal ideation via social support and loneliness separately, and had a serial association through both social support and loneliness. Thus, perceived discrimination may have influenced suicidal ideation through both social support and loneliness.
Oral-Hygiene-Related Mobile Apps in the French App Stores: Assessment of Functionality and Quality
Authors: Carrouel Florence , Bourgeois Denis , Clément Céline , Tardivo Delphine , Martinon Prescilla , Guiral Sébastien , Lan Romain , Viennot Stéphane , Dussart Claude , Fraticelli Laurie
Published: June 2022

Mobile health apps can contribute to increased quality of individual oral hygiene behaviors. This study provides an overview and an evaluation of quality of oral-hygiene-related mobile apps currently available in Google Play Store and the French Apple App. A shortlist of nine apps was assessed by 10 oral health professionals using the Mobile App Rating Scale. Intraclass correlation was used to evaluate interrater agreement. Best quality scores were obtained by Oral-B (3.4 ± 0.97), Colgate Connect (3.20 ± 0.63), and Preventeeth (3.10 ± 1.1) and worst ones by Mimizaur se brosse les dents (1.80 ± 0.79) and Kolibree (2.30 ± 0.82). The subjective quality scores ranged from 2.62 ± 0.61 (Oral-B) to 1.5 ± 0.61 (MSD). Specificity of the content ranged from 3.46 ± 0.84 (Preventeeth) to 1.78 ± 0.47 (Mimizaur se brosse les dents). Thus, even if oral health professionals positively evaluated the quality of oral-hygiene-related mobile apps, they are less assertive concerning their impact on the user’s knowledge, attitudes, and intentions to change, as well as the likelihood of actual change in the oral hygiene behavior. Further investigations are needed to assess whether information from these apps is consistent with oral hygiene recommendations and to determine the long-term impacts of these apps.
Harmful Alcohol and Drug Use Is Associated with Syndemic Risk Factors among Female Sex Workers in Nairobi, Kenya
Authors: Beksinska Alicja , Nyariki Emily , Kabuti Rhoda , Kungu Mary , Babu Hellen , Shah Pooja ,   The Maisha Fiti Study Champions, Nyabuto Chrispo , Okumu Monica , Mahero Anne , Ngurukiri Pauline , Jama Zaina , Irungu Erastus , Adhiambo Wendy , Muthoga Peter , Kaul Rupert , Seeley Janet , Weiss Helen A. , Kimani Joshua , Beattie Tara S.
Published: June 2022

Background: Female Sex Workers (FSWs) are at high risk of harmful alcohol and other drug use. We use quantitative data to describe the prevalence of alcohol and other drug use and identify associated occupational and socio-economic risk factors, and aim to elucidate patterns of alcohol and drug use through information drawn from qualitative data. Methods: Maisha Fiti was a mixed-method longitudinal study conducted in 2019 among a random sample of FSWs in Nairobi, Kenya. We used baseline date from the behavioural–biological survey, which included the WHO Alcohol, Smoking and Substance Involvement Screening Test that measures harmful alcohol and other drug use in the past three months (moderate/high risk score: >11 for alcohol; >4 for other drugs). In-depth interviews were conducted with 40 randomly selected FSWs. Findings: Of 1003 participants, 29.9% (95%CI 27.0–32.6%) reported harmful (moderate/high risk) alcohol use, 21.5% harmful amphetamine use (95%CI 19.1–24.1%) and 16.9% harmful cannabis use (95%CI 14.7–19.2%). Quantitative analysis found that harmful alcohol, cannabis and amphetamine use were associated with differing risk factors including higher Adverse Childhood Experience (ACE) scores, street homelessness, food insecurity (recent hunger), recent violence from clients, reduced condom use, depression/anxiety and police arrest. Qualitative interviews found that childhood neglect and violence were drivers of entry into sex work and alcohol use, and that alcohol and cannabis helped women cope with sex work. Conclusions: There is a need for individual and structural-level interventions, tailored for FSWs, to address harmful alcohol and other drug use and associated syndemic risks including ACEs, violence and sexual risk behaviours.
Environmental Performance Evaluation of Key Polluting Industries in China—Taking the Power Industry as an Example
Authors: Liu Zuoming , Qiu Changbo , Sun Min , Zhang Dongmin
Published: June 2022

This paper analyzes the environmental performance, spatial and temporal characteristics, and optimization paths of key polluting industries, represented here by the power industry, using the super-efficient MinDS model. The study shows that the environmental performance as a whole presents the characteristics of an inverted U-shaped and then a U-shaped trend; each region presents an asymmetric state of convergent development followed by differentiated development, with 2014 as the structural change point; the development trend of environmental performance in each region is divided into three categories (rising, falling, and stable) and four types of spatial clustering (ultra-high, high, medium, and low levels); and input–output indicators of environmental performance in China and across regions have varying degrees of redundancy, with labor input redundancy being the greatest, followed by capital input, technology input, and pollution emissions. On this basis, we propose to improve the monitoring and inspection mechanism of the implementation process of pollution control in key polluting industries and to improve the level of environmental performance of key polluting industries by optimizing the combination of labor, capital, and technology input factors in each region according to local conditions and adopting differentiated strategies. The main contributions of this paper are threefold: first, we incorporate technological inputs into the environmental performance evaluation index system of the electric power industry, which can better reflect the real inputs of the electric power industry and measure the results more accurately; second, we adopt the MinDS model for measuring the environmental performance level, which can quantitatively analyze the gap between each indicator and the optimal level; and third, we propose a redundancy index, which can be used to compare the redundancy of each indicator and then judge the main efficiency levels of the different factors.
Navigating the Unseen City: Town Planners, Architects, Ophthalmic Professionals, and Charity Opinions on Navigating of the Built Environment with a Visual Impairment
Authors: Cushley Laura N. , Galway Neil , Curran Katie , Peto Tunde
Published: June 2022

People with a visual impairment often find navigating around towns and cities difficult. Streetscape features such as bollards, street cafés, and parked cars on pavements are some of the most common issues. in this paper semi-structured interviews were conducted with stakeholders including built environment professionals, visually impaired individuals, ophthalmic professionals, and sight loss charities. All stakeholders felt there were barriers and enablers to navigating streets with a visual impairment. Stakeholders agreed these can have an impact on the daily lives of those with a visual impairment. While built environment professionals knew of policies and guidance around accessibility for people with a visual impairment, there was a lack of professional knowledge about the spectrum of visual impairment. Despite this, stakeholders felt these small changes could have a positive impact, making accessible cities for all. A collaborative approach to streetscape design and further education could help create better environments for all.
The Synergetic Impact of Physical Activity and Fruit and Vegetable Consumption on the Risk of Depression in Taiwanese Adults
Authors: Fann Li-Yun , Huang Shi-Hao , Huang Yao-Ching , Chen Chin-Fu , Sun Chien-An , Wang Bing-Long , Chien Wu-Chien , Lu Chieh-Hua
Published: June 2022

Background: This research focused on the association between physical activity and fruit-vegetable intake and the risk of depression in middle aged and older Taiwanese adults. Methods: Data were obtained from the 1999 to 2015 datasets of the Taiwan Longitudinal Survey on Aging (TLSA), and 4400 participants were included in 1999 (aged ≥53 years). Descriptive statistics provided all of the basic characteristic variables. A chi-square test analyzed the association between sex, age, years of education, marriage, hypertension, drinking, smoking, and the incidence of depression. Logistic regression analysis was used to determine significant associations between physical activity and fruit-vegetable intake, and the presence or absence of depression after 16 years. Results: Combined high physical activity and fruit-vegetable intake reduced the risk of depression by 80% (OR = 0.20, 95% CI = 0.10–0.45, p = 0.001) compared to low physical activity and fruit-vegetable intake; high physical activity and moderate or low fruit-vegetable intake caused a 70% reduction (OR = 0.30, 95% CI = 0.15–0.63, p = 0.005). High fruit-vegetable intake and low physical activity caused a 65% reduction (OR = 0.35, 95% CI = 0.15–0.63, p = 0.005), compared to low physical activity and low fruit-vegetable intake. High physical activity alone caused a 40% reduction, which is the same as by high fruit-vegetable intake alone. Conclusions: Fruit-vegetable intake combined with physical activity was negatively correlated with the risk of depression. More fruit-vegetable intake and physical activity might reduce this risk. The results highlight the importance of physical activity and fruit-vegetable consumption for middle-aged and older adults to prevent depression.
The Mediating Effect of Physical Fitness and Dietary Intake on the Relationship of Physical Activity with Body Composition in High School Students
Authors: Bento André , Carrasco Luis , Raimundo Armando
Published: June 2022

We aimed to investigate the relationship between physical activity (PA) and health-related physical fitness (PF) in adolescents and analyze if the associations of PA with body composition (BC) in adolescents are mediated by physical fitness or energy intake (EI). The participants were 236 adolescents (140 girls 16.1 ± 0.92 years). Cardiorespiratory fitness (CRF) was assessed using the Yo-YoITL1, and the push-up test was used to evaluate strength. BCs were measured on an electrical weight scale. Triaxial accelerometers were used to determine PA levels and moderate-to-vigorous PA (MVPA) levels. EI was estimated with a validated questionnaire. Mediation effects were estimated using bootstrapped 95% confidence intervals and were deemed significant if zero was not included in the intervals. The mediation analysis revealed an indirect effect of MVPA only through PF on BC, specifically through CRF on body fat (B = −0.0146, 95% BootCI (−0.0219; −0.0076)) and on lean body mass (B = 0.0096, 95% BootCI (0.0049; 0.0152)), as well as through upper body strength on body fat (B = −0.012, 95% BootCI (−0.0171; −0.0072)) and on lean body mass (B = 0.0059, 95% BootCI (0.003; 0.0095)). These results suggest that PA of at least a moderate intensity is relevant to BC and health-related PF in adolescents, regardless of the EI.
Construct Validity of the Attitudes towards Maghrebis in Education Scale (AMES)
Authors: Albalá Genol Miguel Ángel , Etchezahar Edgardo , Guido Juan Ignacio , Ungaretti Joaquín
Published: June 2022

The current article describes the validation of the Attitudes towards Maghrebis in Education (AMES) scale in the Spanish context and examines the relation with other psychosocial variables. A Spanish sample of 807 participants aged between 18 and 80 years old completed the AMES. The analyses were performed using CFA, mainly considering the statistical indices of CFI, RMSEA and Pearson’s correlation. The external validity of the scale was tested using measures, such as social dominance orientation (SDO), empathic concern, warmth, competence and contact with Maghrebis. The results indicated that the AMES showed an adequate fit to the data. The AMES was found to be negatively correlated with SDO, whereas it was correlated positively with the rest of the variables. The results demonstrate that the AMES can be used as a reliable measure to evaluate attitudes towards Maghrebi migrants in education in Spain. The implications of the psychosocial variables studied are discussed as possible factors to consider for promoting more intercultural socio-educational environments.
A Qualitative Study Evaluating the Factors Affecting Families’ Adherence to the First COVID-19 Lockdown in England Using the COM-B Model and TDF
Authors: Woodland Lisa , Hodson Ava , Webster Rebecca K. , Amlôt Richard , Smith Louise E. , Rubin James
Published: June 2022

The ability of families to adhere to public health guidance is critical to controlling a pandemic. We conducted qualitative interviews with 30 parents of children aged 18 and under, between 16 and 21 April 2020 when schools in England were closed due to the COVID-19 pandemic. Using the Theoretical Domains Framework, we classified the factors that influenced adherence to seven non-pharmaceutical interventions. We found 40 factors that influenced a family’s ability to adhere. Parents generally indicated they could adhere and reported how their family had changed their behaviour to comply with the guidance. Parents primarily reported they were motivated to adhere out of concern for the health consequences of COVID-19, and because the guidance was delivered by the government. However, we found that reduced access to resources (e.g., technology, transport, and outside space) and social influences that encouraged non-adherent behaviour, decreased adherence. Furthermore, we suggest that families with low psychological and physical ability may face additional challenges to adherence and need to be supported. During future school closures, public health agencies should account for these factors when developing guidance.
Opportunistic Pathogens of Recreational Waters with Emphasis on Antimicrobial Resistance—A Possible Subject of Human Health Concern
Authors: Stec Joanna , Kosikowska Urszula , Mendrycka Mariola , Stępień-Pyśniak Dagmara , Niedźwiedzka-Rystwej Paulina , Bębnowska Dominika , Hrynkiewicz Rafał , Ziętara-Wysocka Joanna , Grywalska Ewelina
Published: June 2022

Infections caused by exposure to opportunistic pathogens can cause serious health problems during recreational water use. The problem of diseases caused by microbes transmitted by water is a major public health challenge, especially in developing countries with economic problems and poor hygiene conditions. Moreover, the quality of water in natural reservoirs is often at a very low level in terms of microbiological water purity, which means that their use for recreational purposes, but also as a source of drinking water, may have serious health consequences. Recreational waters pose a threat to human health. Therefore, the quality of recreational waters is closely monitored in many jurisdictions. In this review, we summarize key information on the most common pathogens that can be water-based or waterborne. The issue of antimicrobial resistance among opportunistic pathogens remains equally important. It is important not only to fight pathogens, but also to take action to reduce chemical stressors (especially antibiotics) in the aquatic environment, and to understand the various mechanisms of the spread of antibiotic-resistant genes.
Health Literacy Development among People with Chronic Diseases: Advancing the State of the Art and Learning from International Practices
Authors: Lander Jonas , Dierks Marie-Luise , Hawkins Melanie
Published: June 2022

Chronic diseases account for a considerable part of the strain on health care systems [...]
Socio-Economic Resilience to Floods in Coastal Areas of Thailand
Authors: Langkulsen Uma , Rwodzi Desire Tarwireyi , Cheewinsiriwat Pannee , Nakhapakorn Kanchana , Moses Cherith
Published: June 2022

Krabi and Nakhon Si Thammarat are two coastal provinces in Thailand facing substantial threats from climate change induced hydrometeorological hazards, including enhanced coastal erosion and flooding. Human populations and livelihoods in these coastal provinces are at greater risk than those in inland provinces. However, little is known about the communities’ resilience and coping capacities regarding hydrometeorological hazards of varying magnitudes. The study conducted a quantitative socio-economic assessment of how people in Krabi and Nakhon Si Thammarat provinces manage and respond to hydrometeorological hazards, examining their resilience and coping capacities. This was a cross-sectional study based on secondary data collection on the social and economic dimensions of resilience, and a review of literature on coping mechanisms to hydrometeorological hazards within the study area. Measuring and mapping socio-economic resilience was based on the available data gathered from the social and economic dimensions, with existing or standard indicators on exposure and vulnerability applied uniformly across subdistricts. A combination of social and economic dimensions produced novel socio-economic resilience index scores by subdistrict, which were mapped accordingly for the two coastal provinces. The study also derived a coping capacity index scores by combining availability of skills or soft capacity and availability of structural resources or hard coping capacity. Socio-economic resilience index scores varied greatly amongst subdistricts. Combining the soft and hard coping capacities, the average score across districts in both provinces was 3 out of a possible 4, meaning that most of the districts were largely resilient. However, variations also existed by subdistrict. Few subdistricts in both Krabi and Nakhon Si Thammarat provinces had low coping capacity index scores between 1 and 2 out of 4. District averages of socio-economic resilience scores mask the variations at subdistrict level. More studies with rigorous methodologies at village or neighborhood level is needed to obtain a nuanced understanding of community resilience to hydrometeorological hazards.
Neurodevelopment in Normocephalic Children Exposed to Zika Virus in Utero with No Observable Defects at Birth: A Systematic Review with Meta-Analysis
Authors: Marbán-Castro Elena , Vazquez Guillamet Laia J. , Pantoja Percy Efrain , Casellas Aina , Maxwell Lauren , Mulkey Sarah B. , Menéndez Clara , Bardají Azucena
Published: June 2022

Zika virus (ZIKV) infection during pregnancy is a cause of pregnancy loss and multiple clinical and neurological anomalies in children. This systematic review aimed to assess the effect of ZIKV exposure in utero on the long-term neurodevelopment of normocephalic children born to women with ZIKV infection in pregnancy. This review was conducted according to the PRISMA guidelines for systematic reviews and meta-analyses. We performed a random effects meta-analysis to estimate the cross-study prevalence of neurodevelopmental delays in children using the Bayley Scales for Infant and Toddler Development (BSID-III). The risk of bias was assessed using Cochrane’s Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Full-text reviews were performed for 566 articles, and data were extracted from 22 articles corresponding to 20 studies. Nine articles including data from 476 children found 6.5% (95% CI: 4.1–9.3) of infants and children to have any type of non-language cognitive delay; 29.7% (95% CI: 21.7–38.2) to have language delay; and 11.5% (95% CI: 4.8–20.1) to have any type of motor delay. The pooled estimates had a high level of heterogeneity; thus, results should be interpreted with caution. Larger prospective studies that include a non-exposed control group are needed to confirm whether ZIKV exposure in utero is associated with adverse child neurodevelopmental outcomes.
Can Digital Financial Inclusion Promote Green Innovation in Heavily Polluting Companies?
Authors: Xue Long , Zhang Xuemang
Published: June 2022

This paper takes the China A-shares listed companies in heavy polluting industries from 2011 to 2020 as samples, combines the digital financial inclusion index to empirically examine the impacts of digital financial inclusion development on the green technology innovation of heavily polluting companies, and reveals its mechanism of action and its heterogeneity of the impacts of enterprises’ green technology innovation in different development stages. The empirical research results show that the development of digital financial inclusion is able to promote the green innovation of heavy-polluting enterprises. Its main manifestation is that the development of digital financial inclusion helps the increase of green patent applications of heavy-polluting enterprises. This conclusion is validated through the endogeneity and robustness tests. The test results of the mechanism of action show that digital financial inclusion promotes green innovation of enterprises by alleviating corporate financing constraints and financial mismatch problems. Further research results show that the role of digital financial inclusion in promoting green technology innovation in heavy-polluting enterprises is more pronounced in mature enterprises. Therefore, this study provides a theoretical basis for the development of digital financial inclusion to promote heavy-polluting enterprises to achieve green transition through green technology innovation, thus achieving the “dual carbon” goal.
A Study of the Buffer Capacity of Polyelectrolyte Microcapsules Depending on Their Ionic Environment and Incubation Temperature
Authors: Dubrovskii Alexey V. , Kim Aleksandr L. , Musin Egor V. , Tikhonenko Sergey A.
Published: June 2022

Polyelectrolyte microcapsules (PMCs) are used in the development of new forms of drugs, coatings and diagnostic systems. Their buffer capacity, depending on the conditions of the medium, has not been practically studied, although it can affect the structure of both the capsule itself and the encapsulated agents. In this connection, we studied the buffer capacity of polyelectrolyte microcapsules of the composition (polystyrene sulfonate/polyallylamine)3 ((PSS/PAH)3) depending on the concentration and the type of salt in solution, as well as the microcapsule incubation temperature. It was found that the buffer capacity of microcapsules in the presence of mono- and di-valent salts of the same ionic strength did not differ practically. Increasing the NaCl concentration to 1 M led to an increase of buffer capacity of PMCs at pH ≥ 5, and an increase in NaCl concentration above 1 M did not change buffer capacity. The study of the buffer capacity of pre-heated PMCs showed that buffer capacity decreased with increasing incubation temperature, which was possibly due to the compaction of the PMCs and an increase in the number of compensated PAH sites. The addition of 1 M sodium chloride to heated PMCs presumably reversed the process described above, since an increase in the ionic strength of the solution led to an increase of the buffer capacity of the PMCs. The effects described above confirm the hypothesis put forward that the buffer properties of microcapsules are determined by uncompensated PAH regions in their composition.
The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review
Authors: Szydełko-Gorzkowicz Magdalena , Poniedziałek-Czajkowska Elżbieta , Mierzyński Radzisław , Sotowski Maciej , Leszczyńska-Gorzelak Bożena
Published: June 2022

Kisspeptins are the family of neuropeptide products of the KISS-1 gene that exert the biological action by binding with the G-protein coupled receptor 54 (GPR54), also known as the KISS-1 receptor. The kisspeptin level dramatically increases during pregnancy, and the placenta is supposed to be its primary source. The role of kisspeptin has already been widely studied in hypogonadotropic hypogonadism, fertility, puberty disorders, and insulin resistance-related conditions, including type 2 diabetes mellitus, polycystic ovary syndrome, and obesity. Gestational diabetes mellitus (GDM), preeclampsia (PE), preterm birth, fetal growth restriction (FGR), or spontaneous abortion affected 2 to 20% of pregnancies worldwide. Their occurrence is associated with numerous short and long-term consequences for mothers and newborns; hence, novel, non-invasive predictors of their development are intensively investigated. The study aims to present a comprehensive review emphasizing the role of kisspeptin in the most common pregnancy-related disorders and neonatal outcomes. The decreased level of kisspeptin is observed in women with GDM, FGR, and a high risk of spontaneous abortion. Nevertheless, there are still many inconsistencies in kisspeptin concentration in pregnancies with preterm birth or PE. Further research is needed to determine the usefulness of kisspeptin as an early marker of gestational and neonatal complications.
Subwavelength Grating Waveguide Structures Proposed on the Low-Cost Silica–Titania Platform for Optical Filtering and Refractive Index Sensing Applications
Authors: Butt Muhammad A. , Tyszkiewicz Cuma , Wojtasik Katarzyna , Karasiński Paweł , Kaźmierczak Andrzej , Piramidowicz Ryszard
Published: June 2022

The sol–gel dip-coating method is a cost-efficient way for the realization of thin films on a planar substrate. In this work, high-quality, low-loss, and low-surface roughness silica–titania thin films are deposited on a glass substrate with the sol–gel dip-coating method. This platform works in the visible to near-IR wavelength ranges and can be useful for several eye-catching photonic components. The paper is comprised of two parts: the first part deals with the development of a low-cost silica–titania waveguide system, whereas the second part provides detail on the numerical modeling of the SWG waveguide filter and SWG waveguide FP-sensor design. The SWG waveguide NIR-stopband filter can achieve an ER of >40 dB and 3-dB bandwidth of 110 nm designed at optimized parameters. The SWG waveguide-FP structure proposed in this work act as a refractive index sensor where the sensitivity is ~120 nm/RIU by reducing the width of the waveguide. This sensitivity can be further enhanced by reducing the waveguide height. We believe that this work is quite important for the realization of low-cost integrated photonic devices based on the silica–titania platform developed via the sol–gel dip-coating method.
Customized Utilization Strategies of Industrial Lignin to Produce Adsorbents and Flocculants Based on Fractionation and Adequate Structural Interpretation
Authors: Wang Lei , Yang Dewei , Li Xiaohan , Zhu Xinyi , Jiang Jungang , Zhang Yifan , Chen Xue , Yu Hongbo
Published: June 2022

Lignin, a by-product of pulping and biorefinery, has great potential to replace petrochemical resources for wastewater purification. However, the defects of lignin, such as severe heterogeneity, inferior reactivity and poor solubility, characterize the production process of lignin-based products by high energy consumption and serious pollution. In this study, several lignin fractions with relatively homogeneous structure were first obtained by organic solvent fractionation, and their structures were fully deciphered by various characterization techniques. Subsequently, each lignin component was custom-valued for wastewater purification based on their structural characteristics. Benefiting from the high reactivity and reaction accessibility, the lignin fraction (lignin-1) refined by dissolving in ethanol and n-butanol could been used as a raw material to produce cationic lignin-based flocculant (LBF) in a copolymerization system using green, cheap and recyclable ethanol as solvent. The lignin fraction (lignin-2) extracted by methanol and dioxane showed low reactivity and high carbon content, which was used to produce lignin-based activated carbon (LAC) with phosphoric acid as activator. Moreover, the influences of synthetic factors on the purification capacity were discussed, and the LBF and LAC produced under the optimal conditions showed distinguished purification effect on kaolin suspension and heavy metal wastewater, respectively. Furthermore, the corresponding purification mechanism and external factors were also elaborated. It is believed that this cleaner production strategy is helpful for the valorization of lignin in wastewater resources.
Proteolysis Targeting Chimeric Molecules: Tuning Molecular Strategies for a Clinically Sound Listening
Authors: Pedrucci Federica , Pappalardo Claudia , Marzaro Giovanni , Ferri Nicola , Ferlin Alberto , De Toni Luca
Published: June 2022

From seminal evidence in the early 2000s, the opportunity to drive the specific knockdown of a protein of interest (POI) through pharmacological entities called Proteolysis Targeting Chimeric molecules, or PROTACs, has become a possible therapeutic option with the involvement of these compounds in clinical trials for cancers and autoimmune diseases. The fulcrum of PROTACs pharmacodynamics is to favor the juxtaposition between an E3 ligase activity and the POI, followed by the ubiquitination of the latter and its degradation by the proteasome system. In the face of an apparently modular design of these drugs, being constituted by an E3 ligase binding moiety and a POI-binding moiety connected by a linker, the final structure of an efficient PROTAC degradation enhancer often goes beyond the molecular descriptors known to influence the biological activity, specificity, and pharmacokinetics, requiring a rational improvement through appropriate molecular strategies. Starting from the description of the basic principles underlying the activity of the PROTACs to the evaluation of the strategies for the improvement of pharmacodynamics and pharmacokinetics and rational design, this review examines the molecular elements that have been shown to be effective in allowing the evolution of these compounds from interesting proof of concepts to potential aids of clinical interest.
RNAi as a Foliar Spray: Efficiency and Challenges to Field Applications
Authors: Hoang Bao Tram L. , Fletcher Stephen J. , Brosnan Christopher A. , Ghodke Amol B. , Manzie Narelle , Mitter Neena
Published: June 2022

RNA interference (RNAi) is a powerful tool that is being increasingly utilized for crop protection against viruses, fungal pathogens, and insect pests. The non-transgenic approach of spray-induced gene silencing (SIGS), which relies on spray application of double-stranded RNA (dsRNA) to induce RNAi, has come to prominence due to its safety and environmental benefits in addition to its wide host range and high target specificity. However, along with promising results in recent studies, several factors limiting SIGS RNAi efficiency have been recognized in insects and plants. While sprayed dsRNA on the plant surface can produce a robust RNAi response in some chewing insects, plant uptake and systemic movement of dsRNA is required for delivery to many other target organisms. For example, pests such as sucking insects require the presence of dsRNA in vascular tissues, while many fungal pathogens are predominately located in internal plant tissues. Investigating the mechanisms by which sprayed dsRNA enters and moves through plant tissues and understanding the barriers that may hinder this process are essential for developing efficient ways to deliver dsRNA into plant systems. In this review, we assess current knowledge of the plant foliar and cellular uptake of dsRNA molecules. We will also identify major barriers to uptake, including leaf morphological features as well as environmental factors, and address methods to overcome these barriers.
Killing Two Birds with One Stone: Potential Therapies Targeting Psoriasis and Atherosclerosis at the Same Time
Authors: Merzel Šabović Eva Klara , Starbek Zorko Mateja , Janić Miodrag
Published: June 2022

Psoriasis is a chronic systemic inflammatory disease. Due to systemic inflammation, it is associated with many comorbidities. Among them, cardiovascular diseases represent the most common causes of morbidity and mortality in this population. Therefore, physicians treating patients with psoriasis should keep in mind that, as important as the treatment of psoriasis, awareness of cardiovascular risk deserves additional attention. Thus, in parallel with psoriasis treatment, a cardiovascular risk assessment must also be performed and addressed accordingly. In addition to encouraging non-pharmacologic strategies for a healthy lifestyle, physicians should be familiar with different pharmacologic options that can target psoriasis and reduce cardiovascular risk. In the present article, we present the pathophysiological mechanisms of the psoriasis and cardiometabolic interplay, our view on the interaction of psoriasis and cardiovascular disease, review the atherosclerotic effect of therapeutic options used in psoriasis, and vice versa, i.e., what the effect of medications used in the prevention of atherosclerosis could be on psoriasis.
Mitochondrial Research: Yeast and Human Cells as Models
Authors: Ždralević Maša , Giannattasio Sergio
Published: June 2022

The evolution of complex eukaryotes would have been impossible without mitochondria, key cell organelles responsible for the oxidative metabolism of sugars and the bulk of ATP production [...]
An Accurate Detection Approach for IoT Botnet Attacks Using Interpolation Reasoning Method
Authors: Almseidin Mohammad , Alkasassbeh Mouhammd
Published: June 2022

Nowadays, the rapid growth of technology delivers many new concepts and notations that aim to increase the efficiency and comfort of human life. One of these techniques is the Internet of Things (IoT). The IoT has been used to achieve efficient operation management, cost-effective operations, better business opportunities, etc. However, there are many challenges facing implementing an IoT smart environment. The most critical challenge is protecting the IoT smart environment from different attacks. The IoT Botnet attacks are considered a serious challenge. The danger of this attack lies in that it could be used for several threatening commands. Therefore, the Botnet attacks could be implemented to perform the DDoS attacks, phishing attacks, spamming, and other attack scenarios. This paper has introduced a detection approach against the IoT Botnet attacks using the interpolation reasoning method. The suggested detection approach was implemented using the interpolation reasoning method instead of the classical reasoning methods to handle the knowledge base issues and reduce the size of the detection fuzzy rules. The suggested detection approach was designed, tested, and evaluated using an open-source benchmark IoT Botnet attacks dataset. The implemented experiments show that the suggested detection approach was able to detect the IoT Botnet attacks effectively with a 96.4% detection rate. Furthermore, the obtained results were compared with other literature results; the accomplished comparison showed that the suggested method is a rivalry with other methods, and it effectively reduced the false positive rate and interpolated the IoT Botnet attacks alerts even in case of a sparse rule base.
Characterization of Potential Molecular Markers in Lac Insect Kerria lacca (Kerr) Responsible for Lac Production
Authors: Bashir Nawaz Haider , Wang Weiwei , Ling Xiaofei , Zhang Jinwen , Lu Qin , He Rui , Chen Hang
Published: June 2022

Kerria lacca (Kerr) is an important lac insect extensively used in industrial products in the form of resin, wax and dye. The scarce knowledge on molecular markers for K. lacca is a barrier in elucidating genetic information. Our study identified a total of 16,921 single-nucleotide polymorphisms (SNPs), and 6231 insertions and deletions (InDels)—of which, intergenic variation accounted for 41.22% and 56.30%, and exonic variation accounted for 39.10% and 17.46%, of SNPs and InDels, respectively. Observation of SNPs suggested that nucleotide substitution frequency and transition to transversion (Ts/Tv) ratio were highest at the late adult stage, 3.97, compared to at the other stages, with a genome-wide Ts/Tv ratio of 2.95. The maximum number of SNPs, 2853 (16.86%), was identified in chromosome 8, while the lowest, 1126 (6.65%), was identified in chromosome 7. The maximum and minimum numbers of InDels were located on chromosome 1 and 7, with 834 (13.38%) and 519 (8.33%), respectively. Annotation showed that highest numbers of exonic and intergenic SNPs were present at the late adult stage, whereas the maximum number of InDels was found at the larval stage. On the basis of gene function, 47 gene variations were screened and 23 candidate genes were identified in associations with lac production. Concluding work will enhance knowledge on molecular markers to facilitate an increase in lac production in K. lacca as well as other lac insects.
Mobile-PolypNet: Lightweight Colon Polyp Segmentation Network for Low-Resource Settings
Authors: Karmakar Ranit , Nooshabadi Saeid
Published: June 2022

Colon polyps, small clump of cells on the lining of the colon, can lead to colorectal cancer (CRC), one of the leading types of cancer globally. Hence, early detection of these polyps automatically is crucial in the prevention of CRC. The deep learning models proposed for the detection and segmentation of colorectal polyps are resource-consuming. This paper proposes a lightweight deep learning model for colorectal polyp segmentation that achieved state-of-the-art accuracy while significantly reducing the model size and complexity. The proposed deep learning autoencoder model employs a set of state-of-the-art architectural blocks and optimization objective functions to achieve the desired efficiency. The model is trained and tested on five publicly available colorectal polyp segmentation datasets (CVC-ClinicDB, CVC-ColonDB, EndoScene, Kvasir, and ETIS). We also performed ablation testing on the model to test various aspects of the autoencoder architecture. We performed the model evaluation by using most of the common image-segmentation metrics. The backbone model achieved a DICE score of 0.935 on the Kvasir dataset and 0.945 on the CVC-ClinicDB dataset, improving the accuracy by 4.12% and 5.12%, respectively, over the current state-of-the-art network, while using 88 times fewer parameters, 40 times less storage space, and being computationally 17 times more efficient. Our ablation study showed that the addition of ConvSkip in the autoencoder slightly improves the model’s performance but it was not significant (p-value = 0.815).
Using Variable Slope Total Derivative Estimations to Pick between and Improve Macro Models
Authors: Leightner Jonathan
Published: June 2022

Using the same data set, a researcher can obtain very different reduced form estimates just by assuming different macroeconomic models. Reiterative Truncated Projected Least Squares (RTPLS) or Variable Slope Generalized Least Squares (VSGLS) can be used to estimate total derivatives that are not model dependent. These estimates can be used to pick between competing macro models, improve current models, or create new models. A selected survey of RTPLS estimates in the literature reveals several common patterns: (1) as income inequality has surged around the world, the effect of changes in government spending (G), exports (X), and money supply (M-1) on Gross Domestic Product (GDP) have plummeted, (2) decreases in G, X, and M-1 cause GDP to fall more than equal increases in G, X, and M-1 cause GDP to rise, and (3) unusually large increases in G and M-1 cause their effect on GDP to plummet. These common patterns fit with a global glut of savings hypothesis, which predicts that an increase in savings will not cause an increase in production expanding investment. An appropriate model could be built around the idea that investors have a choice between investing to increase production or investing to earn rent or interest.