bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of SARS-CoV-2 infection among urban cleaning and solid waste management workers during transmission of the Omicron variant in Brazil
Authors: Martins-Filho Paulo Ricardo , dos Santos Joyce Thayane  da Conceição , Rezende Márcia Santos , de Carvalho Fernanda Oliveira , dos Reis Érica Santos , Barboza Waneska de Souza , Cavalcante Taise Ferreira , dos Santos Cliomar Alves , Quintans-Júnior Lucindo José , Grespan Renata , Corrêa Cristiane Bani , de Moura Tatiana Rodrigues , Schimieguel Dulce Marta , Quintans Jullyana de Souza Siqueira , de Souza Araújo Adriano Antunes
Published: March 2023

This study estimated the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in urban cleaning and solid waste management workers during the transmission of the Omicron variant in one of the poorest regions of Brazil (the state of Sergipe). Nasopharyngeal swabs were collected from 494 workers, and the presence of SARS-CoV-2 RNA was tested by quantitative reverse-transcriptase polymerase chain reaction. Data on socio-demographic characteristics, comorbidities, vaccination status, mask use, and use of public transport to commute to the workplace were collected. The prevalence with a 95% confidence interval (CI) was calculated from the proportion of SARS-CoV-2 positive cases among the total number of individuals tested. The prevalence ratio (PR) with a 95% CI was the measure of association used to evaluate the relationship between SARS-CoV-2 infection and the exposure variables. The prevalence of SARS-CoV-2 infection was 22.5% (95% CI, 19.0 to 26.4). Individuals under the age of 40 had a higher prevalence of infection (PR, 1.53; 95% CI, 1.03 to 2.30) as well as those who did not believe in the protective effect of vaccines (PR, 1.78; 95% CI, 1.05 to 2.89). Our results indicate the need for better guidance on preventive measures against coronavirus disease 2019 among urban cleaning and solid waste management workers.
Dynamic changes in clinical biomarkers of cardiometabolic diseases by changes in exercise behavior, and network comparisons: a community-based prospective cohort study in Korea
Authors: Park JooYong , Choi Jaesung , Kim Ji-Eun , Park Sang-Min , Cho Joo-Youn , Kang Daehee , Lee Miyoung , Choi Ji-Yeob
Published: March 2023

OBJECTIVES: Lifestyles, including exercise behaviors, change continually over time. This study examined whether the clinical biomarkers (CBs) related to cardiometabolic diseases (CMDs) and their relationships differed with changes in exercise behavior.METHODS: The Ansan-Ansung cohort study (third to fifth phases; n=2,668) was used in the current study. Regular exercise behavior was investigated using a yes/no questionnaire. Changes in exercise behavior were classified into 4 groups: Y-N, N-Y, Y-Y, and N-N, with “Y” indicating that a participant regularly engaged in exercise at a given time point and “N” indicating that he or she did not. Fourteen CBs related to CMDs were used, and the associations between changes in exercise behavior and relative changes in CBs were examined. CB networks were constructed and topological comparisons were conducted.RESULTS: Y-N was associated with increases in fasting blood sugar and insulin levels in men, and increased total cholesterol and low-density lipoprotein cholesterol levels in women. Meanwhile, N-Y was inversely associated with body fat percentage, visceral fat percentage, fasting insulin, and triglyceride level. Waist circumference played a central role in most networks. In men, more edges were found in the N-Y and Y-Y groups than in the N-N and Y-N groups, whereas women in the N-Y and Y-Y groups had more edges than those in the N-N and Y-N groups.CONCLUSIONS: Consistent exercise or starting to engage in regular exercise had favorable effects on CBs related to CMDs, although their network patterns differed between the sexes.
Physical activity, sedentary behavior, and cardiovascular disease risk in Korea: a trajectory analysis
Authors: Han Jina , Ju Yeong Jun , Lee Soon Young
Published: March 2023

OBJECTIVES: To identify the distinct trajectories of sedentary behavior (SB) and explore whether reduced cardiovascular disease (CVD) risk was associated with a distinct trajectory of physical activity (PA).METHODS: We analyzed data from 6,425 people who participated in the Korean Health Panel Survey over a period of 10 years. The participants’ self-reported SB and PA were assessed annually, and trajectory groups were identified using a group-based trajectory model for longitudinal data analysis. Logistic regression analysis was performed to assess the association between CVD risk (10-year cumulative incidence) and the trajectories of SB and PA. The adjusted variables included socio-demographic factors, the predisposing diseases of CVD, and baseline health behaviors.RESULTS: Trajectory analysis identified 4 SB trajectory groups: SB group 1 (low and slightly increasing trend, 53.1%), SB group 2 (high and rapidly decreasing trend, 14.7%), SB group 3 (high and slightly decreasing trend, 9.9%), and SB group 4 (low and rapidly increasing trend, 22.2%). The 3 PA trajectory groups were PA group 1 (moderate and slightly decreasing trend, 32.1%), PA group 2 (low and slightly decreasing trend, 57.3%), and PA group 3 (maintained inactivity, 10.7%). By the 10-year follow-up, 577 cases of incident CVD had occurred. We also noted a 50% reduction in the risk of CVD when SB group 4 was accompanied by PA group 1 (odds ratio, 0.50; 95% confidence interval, 0.28 to 0.90).CONCLUSIONS: Despite increased time spent in SB, maintaining PA about 2 days to 3 days per week reduced the occurrence of CVD.
Clinical traits and systemic risks of familial diabetes mellitus according to age of onset and quantity:
an analysis of data from the community-based KoGES cohort study
Authors: Lee Ju-Yeun , Kim Kyungsik , Lee Sangjun , An Woo Ju , Park Sue K.
Published: March 2023

OBJECTIVES: The aim of this study was to clarify the clinical trait of familial diabetes mellitus (DM) by analyzing participants’ risk of DM according to the age of DM onset in parents and siblings, and to evaluate individuals’ risk of DM-associated cardiometabolic diseases.METHODS: Altogether, 211,173 participants aged ≥40 years from the Korean Genome and Epidemiology Study were included in this study. The participants were divided into groups based on the number (1 or 2 relatives) and age of onset (no DM and early, common, or late onset) of familial DM. Participants’ risk of DM was assessed using a Cox regression model with hazard ratios and 95% confidence intervals (CIs). A logistic regression model with odds ratios was used to evaluate associations among the participants’ likelihood of acquiring cardiometabolic diseases such as hypertension, chronic kidney disease (CKD), and cardiovascular disease.RESULTS: The risk of developing DM was 2.02-fold (95% CI, 1.88 to 2.18) and 2.88-fold (95% CI, 2.50 to 3.33) higher, respectively, in participants with 1 and 2 family members diagnosed with familial DM. It was 2.72-fold (95% CI, 2.03 to 3.66) higher in those with early-onset familial DM. In the early-onset group, the respective risks of hypertension and CKD were 1.87-fold (95% CI, 1.37 to 2.55) and 4.31-fold (95% CI, 2.55 to 7.27) higher than in the control group.CONCLUSIONS: The risk of DM and related cardiometabolic diseases was positively associated with the number of family members diagnosed with DM and an early diagnosis in family members with DM.
Tobacco consumption, sales, and output as monitoring indicators in the era of the tobacco endgame: a Korean example
Authors: Kim Hana , Nam Hee-kyoung , Kang Heewon
Published: March 2023

OBJECTIVES: The consumption, sales, and output of tobacco products each suggest different areas of intervention for tobacco control. In the era of the tobacco endgame, as increasingly stronger supply-side measures are implemented, multifaceted indicators that assess both supply and/or demand are required. We aimed to estimate the consumption of cigarette and heated tobacco products (HTPs) and sought agreement between the various indicators.METHODS: The annual cigarette and HTP consumption in 2014-2020 was calculated using the frequency and intensity of cigarette use from representative surveys of adults and adolescents by sex and age. Sales and output data were acquired from governmental sources. Spearman correlation coefficients and Bland–Altman plots were used to compare the indicators.RESULTS: Tobacco output, cigarette sales, and cigarette consumption were greatest in 2014. The HTP consumption calculated for 2020 was 292.28 million packs. Cigarette consumption and sales correlated significantly, as did tobacco output and tobacco sales. A Bland–Altman plot comparing the difference between cigarette consumption and sales showed that this difference was largest in 2014, immediately before cigarette prices increased. With the exception of a single year, all cigarette consumption values were within the limits of agreement for cigarette sales and tobacco output.CONCLUSIONS: Our analyses showed agreement between demand-side (tobacco consumption) and supply-side (sales and output) indicators. We recommend using all indicators to monitor the impacts of tobacco control on both demand and supply sides. The systematic use of various indicators is critical to achieve the end of the tobacco epidemic.
Impaired pulmonary function mediates the impact of preterm birth on later-life stroke: a 2-step, multivariable Mendelian randomization study
Authors: Guo Xingzhi , Tang Peng , Hou Chen , Liu Yue , Li Rui
Published: March 2023

OBJECTIVES: Observational studies have suggested an association between preterm birth and stroke in late adulthood, but it remains unclear whether the association is causal. The purpose of this study was to evaluate the causal effects of gestational age on stroke and to determine the pathophysiological mechanisms underlying the causal associations.METHODS: Two-sample Mendelian randomization (MR) was performed to assess the causal effects of fetal gestational duration, early preterm birth (EPB), preterm birth, or postterm birth on stroke and its subtypes. Two-step Mendelian randomization (TSMR) and multivariable Mendelian randomization (MVMR) were additionally used to determine the role of common stroke risk factors, including cardiovascular diseases, hypertension, pulmonary impairment, inflammation, and metabolic diseases, in mediating the causal associations between gestational age and stroke and its subtypes.RESULTS: Genetically predicted EPB increased the risk of cardioembolic stroke (CES; odds ratio [OR], 1.115; 95% confidence interval [CI], 1.036 to 1.200; p=0.004) and large artery stroke (LAS; OR, 1.131; 95% CI, 1.031 to 1.241; p=0.009). The TSMR results showed that EPB was associated with a lower forced expiratory volume in the first second and forced vital capacity ratio (FEV1/FVC) (β=-0.020; 95% CI, -0.035 to -0.005; p=0.009), which increased the risk of CES and LAS. Further MVMR analysis showed that the associations between EPB and stroke disappeared after adjustment for FEV1/FVC.CONCLUSIONS: Our data demonstrate that EPB is causally associated with an elevated risk of CES and LAS, and that pulmonary dysfunction mediates the causal impact of EPB on CES and LAS.
Risk of chronic periodontitis in patients with obstructive sleep apnea in Korea: a nationwide retrospective cohort study
Authors: Kim Seon-Rye , Son Minkook , Kim Yu-Rin
Published: March 2023

OBJECTIVES:The aim of this study was to determine whether the development of chronic periodontitis is more likely among patients who have been newly diagnosed with obstructive sleep apnea (OSA) through an analysis of representative data from the general population.METHODS: A nationwide, population-based, retrospective cohort study was conducted using patient records from the Korean National Health Insurance Service database. For the period 2004-2019, patient data were categorized into 2 groups: a diagnosis of OSA (747 subjects) and no diagnosis of OSA (1,494 subjects). Subsequently, 1:2 propensity score matching was performed to ensure the homogeneity of the 2 groups. To analyze the risk of incident chronic periodontitis, a Cox proportional-hazards model was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs).RESULTS: In the Kaplan-Meier curve, the disease-free probability was significantly lower in the OSA group than in the non-OSA group (p for log-rank test=0.001). The crude HR for the association between OSA and chronic periodontitis was 1.29 (95% CI, 1.16 to 1.43). The multivariable-adjusted HR was calculated at 1.28 (95% CI, 1.15 to 1.42).CONCLUSIONS: This study confirmed a relationship between OSA and chronic periodontitis. Therefore, OSA patients require oral care to prevent the progression of chronic periodontitis from mild to severe.
Effects of sand mining on peri-urban agriculture in Ife East and Ife Central Local Government Areas, Osun State, Nigeria.
Authors: Awoyelu F.E. , Mebo R.A.
Published: March 2023

There is virtually no information on the effects of artisanal sand mining on peri-urban agriculture in Nigeria in general and Osun State in particular. This study assessed the effects of sand mining on peri-urban agriculture in Ife East and Ife Central Local Government Areas of Osun State during 2015-2019. In effect, the study sought to identify and explain the rate and extent of changes in land uses in the study area, evaluate the level of encroachment of sand mining activities into other land use classifications, and examine socioeconomic factors that determined parting of land for sand mining by landowners in the study area between 2015 and 2019. Data were generated from both primary and secondary sources. Multi-stage sampling technique was used to collect primary data from 60 landowners, 30 cultivators and 30 residents giving a total of 120 respondents using structured questionnaire. Mean ages of landowners, farmers and residents were 67.9 years, 39.6 years and 47.3 years respectively. Majority (68.3%) of landowners had no formal education, while majority (73.3%) and (90%) of farmers and residents had formal education. Majority (68.3%) of landowners were farmers while majority (66.7%) and (76.7%) of farmers and residents were employees of governments. Majority (93.3%) of landowners were males, 100% of farmers were males. Cultivated land area decreased from 48% to 23.2% (–24.8%), built-up area increased from 37.3% to 41.8% (4.5%) while sand-mined area substantially increased from 14.6% to 35% (20.4%). Parting of land for sand mining increased with increasing age, household size and primary occupation being farming while parting of land for sand mining decreased with higher level of education. It is therefore recommended that all levels of government in the country should embark on close monitoring of land use to prevent frequent occurrence of land and environmental degradation. Additionally, Land Use Act of 1978 should be reviewed by bringing all stakeholders together to deliberate on how to prevent multiple land ownership and conflicts.
Hazard perceptions and self-reported non-injury occupational ailments among road construction workers in three Middle Zone Regions of Ghana
Authors: Yankson I. K. , Okyere P. , Bapula A. , Otupiri E. , Afukaar F. K. , Donkor P. , Owusu-Dabo E. , Mock C.
Published: March 2023

Road construction activities are hazardous. Workers are exposed to hazards with high probability of illness, injury, disability or death. The objective was to determine road workers' perceptions of occupational hazards, ailments experienced and health seeking behaviour. This was an institution-based descriptive cross-sectional study using open-ended questions. A total of 353 road workers from Ashanti, Ahafo and Western North regions reported work-related hazards and ranked the top-3. Workers in each craft/stratum who gave consent were included in the study and interviewed. They also reported work-related ailments and health-seeking behaviour. The workers were primarily young (mean age 32.4 years) and male (97.7%). Most (70.2%) workers were contract/casual staff. 38 hazards were reported, with the top five being dust (91.5% of workers reported this), extreme temperatures (72.0%), noise (40.5%), fumes (21.8%) and vehicles/trucks (21.1%). Most (86.8%) workers reported a work-related ailment, with the most common being cough (41.1%) and headache (18.9%). Most (87.8%) workers with ailments sought treatment of any kind. Road construction workers in these regions of Ghana have good appreciation of hazards at work and the dangers they pose. Works supervisors should encourage workers on PPE use against dust, noise, fumes and good housekeeping. Regular worker-training on hazards is recommended.
Hypertension and associated factors among patients attending HIV clinic at Korle-Bu Teaching Hospital
Authors: T. Nartey Edmund , A. Tetteh Raymond , Anto Francis , Sarfo Bismark , Kudzi William , M. Adanu Richard
Published: March 2023

Objectives: This study determined the prevalence of hypertension and its associated factors among patients attending the HIV clinic at the Korle-Bu Teaching Hospital (KBTH).Design: A hospital-based cross-sectional study was conducted at KBTH. The prevalence of hypertension was estimated among study participants, and socio-demographic, lifestyle, anthropometric, metabolic and HIV/ART-related factors associated with hypertension were determined by logistic regression modelling.Setting: Study participants were recruited from the HIV clinic at the KBTH.Participants: A total of 311 Persons Living with HIV were recruited as study participantsInterventions: Simple random sampling technique was used to recruit study participants. A questionnaire adapted from the WHO STEPwise approach to chronic disease risk-factor surveillance was used to collect study participants' data.Results: The prevalence of hypertension was 36.7%, and the factors associated with hypertension were increasing age, positive family history of hypertension, minimal exercising, current BMI ≥25.0 kg/m2, total cholesterol level ≥5.17 mmol/L, exposure to anti-retroviral therapy (ART) and increasing duration of ART exposure.Conclusions: This study shows a high prevalence of hypertension among patients attending the HIV clinic at KBTH, associated with exposure to ART and increasing duration of this exposure. Blood pressure monitoring should move from routine to a more purposeful screening of patients for hypertension. Patients with the identified risk factors should be encouraged to have regular blood pressure measurements at home and not only when they visit the HIV clinic.
Association of erectile dysfunction with coronary artery disease in Type 2 Diabetes mellitus
Authors: C. Dsouza Sydney , Rahman Obaid
Published: March 2023

Objectives: Association of severity of Erectile Dysfunction (ED) and coronary artery disease (CAD) in type 2 diabetics based on the number of vessels involvedDesign: an observational, cross-sectional studySetting: tertiary level health care centre                                                                                                                                                                                                   Participants: 104 diabetics, as defined by ADA(American Diabetes Association) criteria, who fulfilled the inclusion criteria of positive coronary angiogram (in the last six months), were selected to participate in the study after obtaining informed consent. Details regarding ED were obtained using the IIEF-5 questionnaire, and based on their scores, participants were divided into four categories ranging from mild to severe.Interventions: use of questionnaire International Index of Erectile Function-5Main outcome measures: Karl Pearson association was done between the number of major coronary vessels involved and the severity of ED. The receiver operating characteristic curve was plotted between ED status and coronary vessels involved to predict the cut-off limit of ED score to predict CAD.Results: Out of 104 diabetics with CAD, 85.5% gave a history of ED. Most participants had mild to moderate degrees of ED, which was reported as occurring 4-6 years before the diagnosis of CAD. Cross tabulation between the severity of ED and association with the number of coronary vessels involved found no statistically significant association (p>0.05). However, ROC analysis showed sufficient accuracy in predicting the severity of CAD.Conclusion: The presence of ED in diabetic patients warrants screening for cardiovascular disease. A clear association between the severity of ED and the number of coronary vessels involved is still questionable.
Health recovery of soil polluted with marble effluents by the inoculation of Mn-tolerant bacteria
Authors: Hassan Tamoor Ul , Rafiq Kalsoom , Hussain Manzoor , Afzal Aftab , Naz Irum , Azeem Muhammad , Ansari Lubna
Published: March 2023

Marble industry is one of the pillars of modern buildings and structures but marble industry’s effluents, organic pollutants and heavy metals are affecting natural ecosystem. In present work, fourteen bacteria were isolated from the rhizo-surface soil, receiving marble industry effluent from Hattar industrial area. The soil was heavily polluted with manganese (Mn). Among isolated strains Rothia sp, Methylobacterium sp, Pantoea eucrina and Bacillus safensis were found strong phosphate solublizer, indole acetic and organic acids producers. B. safensis and P. eucrina exhibited strong tolerance at 1750 ppm and 2000 ppm of MnSO4; and were applied alone and in consortium to naturally polluted soil collected from Hattar in a green house on maize (Zea mays L.). Consortium + recommended dose of fertilizers (RDF) and different concentrations of MnSO4 improved 12-25% of plant biomass. Plants grown in naturally polluted soil of marble industry exhibited 50-60% increases in growth indices in single inoculation, and these increases were 65% in consortium application. Plants grown in naturally polluted soil exhibited 30-45% increases in physiological indices. It is inferred that Mn stressed soil may be reclaimed by the application of B. safensis and P. eucrina.
Effect of microplastics on soil microbial community and microbial degradation of microplastics in soil: A review
Authors: Omidoyin Kehinde Caleb , Jho Eun Hea
Published: March 2023

The mass production, continual usage, and improper disposal of plastic products have resulted in significant environmental pollution. The larger plastic polymers gradually break down into smaller particles called microplastics (<5 mm). Existing studies on the occurrence and ecological impact of microplastics have focused on the aquatic ecosystems, with very little attention given to the soil environment. The soil represents a natural sink for microplastics from sources such as sewage sludge, landfills, plastic mulch from agricultural activities, fertilizers, and municipal wastewater effluent. The current study, therefore, provides an overview of existing knowledge on soil microplastic pollution focusing on the impact of microplastics on soil microbial community and microbial degradation of microplastics in soil to systematically identify knowledge gaps to be filled with further research. Future research challenges to be addressed include detailed monitoring of the sources and distribution of microplastics in soil under different land uses, exploring diverse microorganisms in their natural environments for their microplastic biodegradation potential using cultivation-dependent and independent approaches, understanding the mechanism of ecological impacts of microplastics and contributions of microplastic additives, degradation products, and other adsorbed environmental pollutants on soil microbial community.
XÁC ĐỊNH MÃ VẠCH DNA CHO HAI LOÀI NGHỆ MỚI (CURCUMA) Ở VIỆT NAM
Authors: VĂN HỒNG THIỆN  , TRẦN ĐÌNH THẮNG  , LÊ VĂN SƠN  , NGUYỄN PHI NGÀ  , LƯU HỒNG TRƯỜNG  , TRẦN HỮU ĐĂNG  , TRỊNH NGỌC NAM
Published: March 2023

Curcuma xanthella và C. cotuana là hai loài mới được mô tả gần đây với mẫu vật thu tại Việt Nam. Nghiên cứu này đã khuếch đại và giải trình tự thành công vùng trình tự ITS, trnL-F và matK cho loài C. xanthella cũng như vùng ITS2, trnL-F và matK cho loài C. cotuana. Kết quả từ nghiên cứu này đã bổ sung một số vị trí nucleotide chưa rõ ràng trên vùng ITS của mẫu C. xanthella chuẩn (Lý 348) hiện có trên cơ sở dữ liệu GenBank. Ngoài ra, thông qua các vùng trình tự, nghiên cứu này cũng cho thấy sự khác biệt về đặc điểm di truyền giữa 2 loài nghiên cứu với các loài có đặc điểm hình thái tương tự thuộc chi Curcuma.
Foundations of Educational Technology: Integrative Approaches and Interdisciplinary Perspectives
Authors: Öztürk İbrahim Hakkı
Published: March 2023

This paper reviews the book “Book Review: Foundations of Educational Technology. Integrative Approaches and Interdisciplinary Perspectives”, written by J. Michael Spector (published in 2016 by Routledge, 2nd edition, first edition in 2012, 253 p.).
Pro-apoptotic Bax mRNA expression: A novel predictor for systemic lupus erythematosus disease flare-up
Authors: Yousef Rasha N , Ramadan Abeer , Awadallah Eman , Alnaggar Alshaimaa R , Khalil Noha M , E.Behiry Mervat , Ali Asmaa , El Dine Hesham Gamal
Published: March 2023

Objectives: In this study, we aimed to better understand the expression of pro-apoptotic Bad and Bax in the pathogenesis of systemic lupus erythematosus (SLE) and their relationship with the disease activity.

Patients and methods: Between June 2019 and January 2021, a total of 60 female patients with SLE (median age 29 years; IQR, 25.0-32.0) and 60 age- and sex-matched healthy female controls (median age: 30 years; IQR, 24.0-32.0) were included. The Bax and Bad messenger ribonucleic acid (mRNA) expression was measured by real-time polymerase chain reaction.

Results: The expression of Bax and Bad was significantly lower in SLE group than the control group. The median value of mRNA expression of Bax and Bad was 0.72 and 0.84, respectively versus 0.76 and 0.89 in the control group. The median value of (Bax*Bad)/β-actin index was 17.8 in the SLE group and 19.64 in the control group. The expression of both Bax, Bad and (Bax*Bad)/β-actin index had a good significant diagnostic utility (area under the curve [AUC]= 0.64, 0.70, and 0.65, respectively). The Bax mRNA expression showed a significant upregulation with disease flare-up. The efficacy of Bax mRNA expression in predicting SLE flare-up was good (AUC= 73%). In the regression model, the probability of flare-up reached 100%, with increasing Bax/β-actin as well, and the likelihood of flare-up increased 10,314 times with every unit increase of Bax/β-actin mRNA expression.

Conclusion: Deregulation of the mRNA expression of Bax may have a role in the susceptibility to SLE and may be associated with disease flare. A better understanding of the expression of these pro-apoptotic molecules may carry a great potential for the development of specific effective therapies.
How do COVID-19 vaccines affect rheumatic diseases?
Authors: Altan Lale , Mısırcı Salim , Yağcı İlker , Karacaatlı Meltem , Ünlü Özkan Feyza , Güner Altuğ , Aktaş İlknur
Published: March 2023

Objectives: This study aims to investigate the effects of novel coronavirus disease 2019 (COVID-19) vaccines administered in Türkiye on disease activity and the side effects in the patients with inflammatory rheumatic disease (IRD).

Patients and methods: Between September 2021 and February 2022, a total of 536 patients with IRD (225 males, 311 females; mean age: 50.5±12.6 years; range, 18 to 93 years) who were vaccinated against COVID-19 and followed in the outpatient setting were included in the study. Vaccination status of the patients and whether they had COVID-19 were questioned. All patients were asked to rate their anxiety about the vaccination on a scale of 0-10 before and after the shots. They were asked whether they experienced any side effects and an increase in IRD complaints after vaccination.

Results: A total of 128 (23.9%) patients were diagnosed with COVID-19 before the first vaccination. Totally, 180 (33.6%) patients were vaccinated with CoronaVac (Sinovac) and 214 (39.9%) patients with BNT162b2 (Pfizer-BioNTech). Also, 142 (26.5%) patients were given both vaccines. When the anxiety level of the patients before the first vaccination was questioned, 53.4% reported that they had no anxiety. The rate of patients without any anxiety after vaccination was 67.9%. Comparison of pre- (median Q3=6) and post-vaccine (median Q3=1) anxiety values showed a statistically significant difference (p<0.001). A total of 283 (52.8%) patients reported side effects after vaccination. When both vaccines were compared with each other, the rate of the side effects was higher in the BNT162b2 group (p<0.001) and also in the CoronaVac plus BNT162b2 group (p=0.022). There was no statistically significant difference between BNT162b2 and CoronaVac plus BNT162b2 in terms of side effects (p=0.066). Forty-five (8.4%) patients had increased rheumatic complaints after vaccination.

Conclusion: The lack of a significant increase in disease activity after COVID-19 vaccination in patients with IRD and the absence of serious side effects requiring hospitalization support the safety of vaccines in this patient group.
The use of the project method in the educational process of the higher education institutions for students of historical specialties
Authors: Buhlai Natalia , Marchenko Nataliia , Grabar Natalia , Zatsepina Nataly , Milutina Katerina
Published: March 2023

The article is aimed at clarifying, through a questionnaire survey, certain practical aspects of the use of the project method in the organization of the educational process in higher education institutions. In the course of the study, the analytical and bibliographic method was applied to study the scientific literature on the use of the project method in the educational process. The authors of the study conducted an online questionnaire survey to clarify certain aspects of using the project method in teaching in HEIs practically. Based on the results of the study, the main most important theoretical aspects of the process of using the project method in HEIs for students of historical specialties have been highlighted. The point of view of students and teachers of HEIs on the key practical aspects of this issue has been investigated.
Quality Control Analysis on Steel Construction Projects Using the Method Statistical Quality Control and Failure Mode and Effects Analysis
Authors: Zilfianah Kholidah , Ismiyah Elly , Rizqi Akhmad Wasiur
Published: March 2023

XYZ is a steel fabrication company. It have some business such as; Storage, Crosstube, Steel Structure for pre-heater, Bulk Storage bagging unit and etc. Crosstube produce with a high failure rate, it was 212/2185 defective products. This research goal is to analyse quality control at PT. XYZ from June 2021 to May 2022 using Statistical Quality Control and Failure Mode and Effects Analysis. By using pareto diagram it found that a defect occur during welding process, which is 47% more dominant on the type of product defect. It was realize the RPN value of each process are; 1430 for the welding process, 1748 for drilling process, and 1470 for cutting process. Action that should be taken by PT. XYZ is using statistic method. It is to find out the category that caused product failure. Furthermore, PT. XYZ need to make a Standard Operational Procedure to minimized failure in the production process.

PT. XYZ adalah perusahaan manufaktur fabrikasi baja, bidang usaha jasa yang dijalankannya yaitu Limestone Storage, Crosstube, Steel Structure for Pre-Heater, Bulk Storage Bagging Unit dan lain – lain. Di antara usaha tersebut, Crosstube menjadi produk dengan tingkat kegagalan yang tinggi saat proses produksi, terdapat 212 produk cacat dari 2185 produk yang dihasilkan. Penelitian ini bertujuan untuk menganalisis pengendalian kualitas pada produk PT. XYZ pada bulan Juni 2021-Mei 2022 dengan metode Statistical Quality Control dan Failure Mode and Effects Analysis. Terungkap pada diagram pareto bahwa kecacatan saat melakukan proses las sebesar 47% lebih dominan pada jenis kerusakan produk. RPN pada setiap proses sebesar 1403 pada proses las, 1748 proses bor, 1470 proses cutting. Tindakan yang harus dilakukan oleh PT. XYZ yaitu menggunakan metode statistik untuk dapat mengetahui kategori apa yang menyebabkan terjadinya kegagalan produk. Selain itu PT. XYZ perlu membuat Standard Operasional Prosedure untuk menghindari peningkatan kegagalan produk.
Ceramic Armor as Protective Material in Defense Industry Product: A Literature Review
Authors: Lestari Ary , Melati Leni Tria , Kasim Kasim , Jupriyanto Jupriyanto , Deksino George Royke
Published: March 2023

Ceramics are currently widely used in various defense industries. Among them are the purposes of body armor (vests and helmets), vehicle protection, and ballistic protection. This review aims to provide insight into ceramic armor materials including their manufacture, use, and application as protective materials. The method used is a literature review and describes the results of the analysis related to the application of ceramic materials in the form of ceramic armor. The use of ceramic armor materials in defense industry products is proven to provide good performance compared to metal materials, especially in increasing the mobility capabilities of defense personnel. In addition, the use of ceramic armor has initiated the development of lightweight protective materials so that various technologies have been developed to maximize the use of ceramics in the defense industry.

Keramik saat ini banyak digunakan dalam berbagai industri pertahanan. Diantaranya untuk keperluan bahan pelindung tubuh (rompi dan helm), pelindung kendaraan, dan pelindung balistik. Review ini bertujuan untuk memberikan wawasan tentang material armor keramik yang meliputi pembuatan, penggunaan, dan aplikasinya sebagai bahan pelindung. Metode yang digunakan adalah literatur review dan mendeskripsikan hasil analisa terkait aplikasi material keramik dalam bentuk ceramic armor. Pemanfaatan material armor keramik pada produk industri pertahanan terbukti dapat memberikan performa yang baik dibandingkan dengan material logam terutama dalam meningkatkan kemampuan mobilitas dari personil pertahanan. Selain itu penggunaan armor keramik telah menginisiasi pengembangan material pelindung ringan sehingga berbagai macam teknologi dikembangkan untuk dapat memaksimalkan penggunaan keramik dalam industri pertahanan.
Hazard Identification and Risk Assessment of PT TKA Traksi Employees
Authors: Milana Milana , Putra Kevin Lisson , Fernandez Donny , Setiawan M. Yasep
Published: March 2023

Traksi is a division of work related to transportation at PT TKA. There are cases of work accidents experienced by Traksi employees every year. This study aims to identify potential hazards from the work activities of Traksi employees. Data collection was carried out at the Koto Ubi Garden division through direct observation in the Traksi work area, and employee interviews regarding the activities carried out. The hazard identification process is carried out using the Hazard Identification and Risk Assessment (HIRA) method. From the results of hazard identification, 26 potential hazards can occur to Traksi employees. Meanwhile, from the risk assessment, there are 35% in the extreme category, 31% in the high category, 23% in the low category, and 11% in the medium category.

Traksi merupakan divisi pekerjaan yang berkaitan dengan transportasi di PT TKA. Terdapat kasus kecelakaan kerja yang dialami oleh karyawan Traksi di setiap tahunnya. Penelitian ini bertujuan untuk mengidentifikasi potensi bahaya dari aktivitas kerja karyawan Traksi. Pengambilan data dilakukan pada divisi Kebun Koto Ubi melalui pengamatan langsung di area kerja Traksi, dan melakukan wawancara pekerja mengenai aktivitas kerja yang dilakukan. Proses identifikasi bahaya dilakukan dengan menggunakan metode Hazard Identification and Risk Assessment (HIRA). Dari hasil identifikasi bahaya didapatkan 26 potensi bahaya yang dapat terjadi pada karyawan Traksi. Sedangkan dari penilaian risiko terdapat 35% pada kategori ekstrim, 31% pada kategori tinggi, 23% pada kategori rendah, dan 11% pada kategori sedang.
Analysis Of The Effect Of Role Of Stress, Organizational Culture And Emotional Quotient On Employee Performance With Job Satisfaction As Intervening Variable At Royal Prima Medan Rsu
Authors: Muhammad Arviansyah Shaid , Ria Ginting Rasinta , Romy Elly , Tribuana Sutanto Alex
Published: March 2023

This study aims to partially test and analyze the effect of role of stress, organizational culture and emotional quotes on employee performance of medical and non-medical employees at RSU Royal Prima Medan, to examine and analyze the effect of job satisfaction on employee performance of medical and non-medical employees at RSU. Royal Prima Medan, tested and analyzed the effect of role of stress on job satisfaction of medical and non-medical employees, tested and analyzed the influence of organizational culture on job satisfaction of medical and non-medical employees, tested and analyzed the effect of emotional quotient on job satisfaction of medical and non-medical employees non-medical, testing and analyzing the influence of the role of stress on the employee performance of medical and non-medical employees, testing and analyzing the influence of organizational culture on the employee performance of medical and non-medical employees, as well as testing and analyzing the influence of emotion l quotient on employee performance of medical and non-medical employees at RSU Royal Prima Medan. This study uses a quantitative description of the questionnaire instrument, the population is 692 medical and non-medical people, the probability sampling technique is calculated using the Slovin formula so that the number of samples is 87 people. The data analysis technique used the instrument quality test, the use of classical assumptions, moderated linear regression, t test (partial) and F test (simultaneous), the coefficient of determination test.
The Effect Of Emotional Intelligence And Organizational Culture On Organizational Commitment Through Job Satisfaction As Intervening Variable In PT.Capella Multidanda
Authors: Angelita Indah , Syaifuddin Syaifuddin , Faris Salman
Published: March 2023

This study aims to analyze the influence of emotional intelligence and organizational culture on organizational commitment through job satisfaction as an intervening variable at pt. capella multidana. The population in this study was 492 people, with a sample of 81 people at a 90% confidence interval. The technique used in sampling is purposive sampling. The data analysis tool uses SPSS. The results of the analysis show that emotional intelligence has a positive and insignificant effect on job satisfaction at PT. Capella Multidana. Organizational culture has a positive and insignificant effect on job satisfaction at PT. Capella Multidana. Emotional intelligence has a positive but not significant effect on organizational commitment at PT. Capella Multidana. Organizational Culture has a positive and insignificant effect on organizational commitment at PT. Capella Multidana. Job satisfaction has a positive but not significant effect on organizational commitment at PT. Capella Multidana. The direct effect of emotional intelligence on organizational commitment is smaller than the indirect effect of emotional intelligence on organizational commitment. The direct effect of organizational culture on organizational commitment is smaller than the indirect effect of organizational culture on organizational commitment.
Utilization Of Chitosan As A Natural Preservative Against Catfish
Authors: Nurhayati Nurhayati , Ridwanto Ridwanto , Sartika Daulay Anny , Andi Syahputra Ricky , Rani Zulmai
Published: March 2023

Shrimp in Indonesia are generally exported abroad after removing the head, tail, and skin. One alternative to the use of shrimp shell waste that has high economic value is processing shrimp shells into chitosan. The purpose of this study was to determine the shelf life of catfish using chitosan and to determine the optimal concentration of chitosan in catfish preservation. Chitosan applied to catfish showed that in the addition of a 0% chitosan solution, it had a shelf life of up to day 2 for 48 hours for a 0.5 solution; 1; 1.5 and 2% shelf life up to day 5 or for 120 hours. The most optimal concentration of chitosan for use in catfish is a 2% chitosan solution, and the total plate number (ALT) test meets the requirements of the SNI standard so that it can still be consumed.
The Effect Of Social Media Promotion Instagram, Word Of Mouth (WOM), And Online Customer Review On Students' Decisions To Take Tutoring In Brits Indonesia Institutions
Authors: Arroji Luthfi , Dewi Ruspitasari Widi
Published: March 2023

This study aimed to determine the effect of social media promotion Instagram, Word of Mouth (WOM), and Online Customer Review on students' decisions to take tutoring at BRITS Indonesia Institution. The population in this study were all students who had followed the guidance in November 2021. The sample size was 76 respondents; the sampling technique was purposive sampling technique. The type of data used was sourced from primary data and secondary data. Data was collected using observation, questionnaires, and documentation. The technique used to analyze the data was the technique of multiple linear regression analysis. The results showed that the promotion of social media Instagram (X1) had a significant effect on students' decisions to follow tutoring, word of mouth (X2) had a significant effect on students' decisions to follow tutoring, and electronic word of mouth (X3) had a significant effect on students' decisions to follow tutoring study.
Effect Of Career Development And Work Motivation On Employee Performance With Job Satisfaction As Intervening Variable At PT.Mark Dynamic Medan
Authors: Sembiring Lea Rosa , Ronny Edward Yusuf , Fitri Rostina Cut
Published: March 2023

This study aims to determine whether career development and work motivation affect employee performance through job satisfaction as an intervening variable at PT. Mark Dynamic Medan. The study was conducted on 85 employees of PT. Mark Dynamic Medan by using the Slovin formula sampling technique. The data collection technique used is primary data in the form of questionnaires and secondary data obtained through documentation studies. The data analysis technique uses quantitative data which is processed with SPSS version 25 program, namely t test, coefficient of determination (R2) and path analysis. The results obtained in this study indicate 1) there is a significant influence between career development on job satisfaction, 2) there is a significant influence between work motivation variables on job satisfaction, 3) there is a significant but not significant effect between job satisfaction variables on performance, 4) there is an influence but not significant between career development variables on performance, 5) there is a significant influence between work motivation variables on performance, 6) job satisfaction variables can affect career development variables on performance, 7) job satisfaction variables can affect work motivation variables on performance. The ability of career development variables, work motivation and job satisfaction in explaining employee performance at PT. Mark Dynamic Medan is 62.3%, while the remaining 37.7% is explained by other variables not included in this research model.
The Correlation Between the Number of Heater and Energy Saving on Plastic Injection Molding
Authors: Hastarina Merisha , Wahyudi Bayu , Santoso Budi , Hafizar M. Alrisyad
Published: March 2023

The number of human populations is increasing as well as daily needs and consequently increased the number of wastes that being produced including plastic waste. Indonesia itself consumed 17 kg/capita per year. Recycling the plastic waste is one of alternatives way to reduce waste, by melting the plastic waste using six heaters from electrical energy source. This research was conducted to obtain number of heaters that will be used in the injection molding process by considering the time consumed for the temperature of 50⁰ - 210⁰ C. The observation is being done by measuring the temperature and power supplied from 3, 4, 5 and 6 heaters and repeated for 3 times experiment. Based on the measurement data that has been carried out, it is found that the highest average power is the injection with six numbers of heaters consumed 956.80 W. The time measurement required to reach optimal temperature, for 3 number of heaters was taking the longest time which is 2842 Seconds. This condition is in line with the average of electrical power consumed to reach the optimal temperature is the using of the heaters 0.350 kWh. Based on three hypotheses that being done, the result shows that the Ha is accepted and there is significant influence between three models that being made.
Effect Of Product Quality And Service On Customer Loyalty With Customer Satisfaction As An Intervening Variable (Study On Coffee Shop In Medan)
Authors: Tirtayasa Satria
Published: March 2023

This study is to determine the effect of product quality on consumer loyalty, to determine the quality of service to consumer loyalty. To know the effect of product quality and service quality on customer satisfaction. The type of research used is a type of quantitative research. In this study used 105 sample. Data collection techniques used by researchers in conducting this study is to use an online questionnaire. Data analysis technique of this study is SEM-PLS. From this study it was found that the influence of product quality on customer loyalty is a positive effect and not significant. With a value of 0.163 and P – Values 0.000 < 0.05. From this study it was found that the influence of product quality on customer satisfaction is a positive effect and not significant. With a value of 0.000 < 0.05. From this research found that the influence of customer satisfaction on customer loyalty is a positive and significant effect. From this research found that the influence of customer satisfaction on customer loyalty is a positive and significant effect. From this study it was found that the real effect is direct it is shown by the value of the original sample on the indirect effect of 0.000 < 0.05, meaning that customer satisfaction plays a role in mediating product quality to customer loyalty. From this study it was found that the real effect is direct it is shown by the value of the original sample on the indirect effect of 0.000 < 0.05, meaning that customer satisfaction plays a role in mediating service to customer loyalty.
Product Innovation As A Mediation Variable Influences Market Orientation And Entrepreneurial Orientation In Increasing The Competitive Advantage Of The Msme Sector Processed By Patin Fish In Patin Village, Koto Mesjid Village, District Xiii Koto Kampa
Authors: Fadli Mashur , Heriyanto Meyzi , Kasmirudin Kasmirudin , Othman Lie
Published: March 2023

This study aims to measure the effect of market orientation, entrepreneurial orientation, and product innovation as mediating variables on strategies to increase competitive advantage in the Catfish Processed MSME Sector in Patin Village, Koto Mesjid Village, District XIII Koto Kampar. The study used a quantitative approach where primary data was collected through a survey of 70 respondents, and the statistical technique Partial Least Square (PLS) was used to process the data. The study's results confirm that market orientation significantly affects product innovation and competitive advantage, both direct and indirect effects, through the mediation of product innovation variables. Furthermore, the entrepreneurial orientation variable influences the product innovation variable and competitive advantage, either directly or indirectly, through the product innovation variable. Still, some other factors or variables affect the competitive advantage variable.