bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of a remote knowledge broker from an academic setting using an adaptive approach to implement evidence-based practice in primary care settings: A case study of integrating mood management interventions for treatment seeking tobacco users.
Authors: Minian Nadia , Ahad Sheleza , Zawertailo Laurie , Ravindran Arun , Oliveira Claire de , Baliunas Dolly , Mulder Carol , Selby Peter
Published: January 2020

Background: Knowledge brokering is an emerging knowledge translation strategy used within healthcare to bridge the gap between evidence and practice. Reported studies indicate that the day-to-day role of a knowledge broker often involves in-person communication with frontline workers and decision makers. However, travelling to primary care sites can be cost- and resource-intensive and thus not feasible. In this paper, we describe the role and experience of a remote knowledge broker (rKB) working in an academic health sciences centre, delivering tailored one-on-one support to end-users using phone and email communications. Methods: A rKB was hired to support (n = 62) English-speaking Family Health Teams (FHTs) across Ontario with implementing mood management interventions as part of an existing smoking cessation program, the Smoking Treatment for Ontario Patients (STOP) program. We describe the eight categories of tasks performed by the rKB over a 12-month period, as well as their experience communicating via technology to develop relationships with healthcare providers (HCPs). Results: Sixty-one of the 62 FHTs (n = 73 HCPs) were provided rKB services. The total number of successful phone and email communications with the rKB ranged from 3-98 interactions over 12 months. Common barriers to implementation reported by FHTs were associated with the Inner and Outer Setting domains of the Consolidated Framework for Implementation Research (CFIR) and included lack of time, resources, and patient engagement. Conclusions: The role of the rKB involved building relationships with HCPs, identifying and helping to problem solve barriers, and building capacity in the field. Similar to traditional knowledge brokering, this analysis shows that developing a meaningful relationship between a remotely situated KB and HCPs could take anywhere between 1-6 months. Using implementation frameworks such as CFIR can help the rKB identify barriers and be ready to address them. In addition, hiring a rKB with previous engagements and knowledge of the local context may facilitate clinical practice change. Our future work will evaluate the cost-effectiveness of rKBs to inform its potential to be scaled up.
Dolphinfish Movements in the Eastern Pacific Ocean of Mexico Using Conventional and Electronic Tags
Authors: Perle Christopher R. , Snyder Stephanie , Merten Wessley , Simmons Melinda , Dacey Justina , Rodriguez-Sanchez Ruben , O’Sullivan John , Ortega-Garcia Sofia
Published: January 2020

Background Dolphinfish, Coryphaena hippurus , are fast-swimming, predatory fish that exhibit fast growth and early maturation. It is an important and potentially renewable recreational and commercial resource throughout their global subtropical to tropical range. While understanding habitat utilization and migratory behavior in these wide-ranging fish is critical to proper regional and international fisheries management, studies have historically relied heavily upon fisheries reported data. This study uses tagging data to explore the vertical and horizontal movements of dolphinfish, focusing on two regions in the Eastern Pacific Ocean (EPO) - west coast of Baja California Peninsula (WBC) and Oaxaca (OAX) coasts of Mexico. Results Adult dolphinfish (fork length 66 cm - 129 cm) were tagged with conventional (n = 132 tags) and electronic tags (n = 30 tags, miniPAT) between 2010 and 2014. Total recapture rate was 3.7%, and greater for males (5.1%) than females (2.4%). Twenty of 30 deployed electronic tags reported, but all did so before the programmed release date, with days at liberty ranging from 3 to 74 (mean = 42 d). Fish remained within their tagging region with the exception of one fish tagged in WBC which exhibited a large southerly displacement, and one fish tagged in OAX which was recovered to the north. Latitudinal (N-S) and longitudinal (E-W) extents of fish movements increased with days at liberty. In general, fish remained near the surface with short excursions below the isothermal layer but larger OAX fish inhabiting warm waters (sea surface temperatures (SST) > ~26 °C) spent more time below the isothermal layer than smaller fish inhabiting colder waters in WBC (SST > ~22 °C). Conclusions This study examines the dynamics of the vertical and horizontal movements of dolphinfish. These movements evoke questions about the size-structure of the dolphinfish’s realized thermal niche, its population stock structure, and its spatiotemporal connectivity patterns in the multinational EPO. Longer tag deployments could show larger displacements and observed differences in orientation of seasonal displacement patterns suggest such long-distance movements would provide opportunities for reproductive mixing through trans-national migrations.
A selective p38 MAPK inhibitor alleviates neuropathology and cognitive impairment by modulating microglia function in 5XFAD mouse
Authors: Gee Min Sung , Son Seung Hwan , Jeon Seung Ho , Do Jimin , Kim Namkwon , Ju Yeon-Joo , Lee Soo Jin , Chung Eun Kyoung , Inn Kyung-Soo , Kim Nam-Jung , Lee Jong Kil
Published: January 2020

Background: Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal cell loss and cognitive impairment are pathological symptoms of Alzheimer’s disease (AD). Regarding these symptoms, resolution of neuroinflammation and inhibition of Aβ-driven pathology might be a novel strategy for AD therapy. Efforts to prevent AD progression have identified that p38 mitogen-activated protein kinase (MAPK) is a promising target for AD therapy. However, the actual therapeutic effect of selective p38 MAPK inhibition in AD has not been ascertained yet. Methods: In this study, we explored the therapeutic potential of NJK14047, a selective p38 MAPK inhibitor, using an Alzheimer’s disease mouse model, 5XFAD. The mice were injected 2.5 mg/kg NJK14047 or vehicle every other day for 3 months. Morris water maze task and histological imaging analysis were performed. Protein and mRNA expression levels were measured using immunoblotting and qRT-PCR. In in vitro studies, the cytotoxicity of microglial conditioned medium and astrocyte conditioned medium on primary neurons were measured using MTT assay and TUNEL assay. Results: NJK14047 treatment downregulated phospho-p38 MAPK levels, decreased the amount of Aβ deposits, and improved spatial learning memory in 5XFAD mice. Interestingly, these effects were associated with the decrease of inflammatory responses and the elevation of alternatively activated M2 markers. Furthermore, NJK14047 treatment reduced the number of Fluoro-jade B positive cells, a class of degenerating neurons, in the brains of 5XFAD mice. The neuroprotective effect of NJK14047, achieved via the restoration of microglia function, was further confirmed by in vitro studies. Conclusion: Taken together, our results reveal that inhibition of p38 MAPK in the brain alleviates AD pathology and represents a potential strategy for AD therapy. It also suggests that NJK14047 is a promising candidate for AD treatment. Keywords : Alzheimer’s disease, Amyloid-β, P38 mitogen-activated protein kinase, Kinase inhibitor, Microglia
Upper gastrointestinal bleeding in patients with liver cirrhosis, Is the difference of clinical outcomes depend on the source?
Authors: Mohamed Mohamed Sorour , Elgohary Marwan N , Bassiony Mohamed A A , Hanafy Amr Shaaban
Published: January 2020

Background and Study Aims Acute upper gastrointestinal bleeding (UGIB) is the most common gastroenterological emergency in patients with cirrhosis; It increases the hospital length of stay (LOS), and Chance of 30-day hospital readmission. It has not been clarified if there is a difference in the prognosis of UGIB in cirrhosis depending on the source of bleeding. We aimed to investigate clinical outcomes in patients with cirrhosis with either acute variceal bleeding (AVB) or non-variceal bleeding (NVB) and risk factors for prolonged hospital LOS in both groups.Patients and Methods From July 2016 to January 2017, all adult eligible patients hospitalized with cirrhosis and UGIB were enrolled in the retrospective study, we assessed clinical outcomes in both groups and factors associated with prolonged hospital LOS.Results Of the 608 patients included in the study, 416 had variceal and 192 non-variceal bleeding. Mortality was higher in AVB group compared to NVB (12.5% vs. 8.3%, P= 0.023). There was a trend towards increased the length of hospital stay for those who had an AVB compared to NVB (5.84±2.16 vs. 4.33±1.18, p=0.001). Rate of hospital Readmission was also higher in the AVB group. Risk factors for prolonged hospital LOS were in hospital rebleeding, presence of Hepatic encephalopathy or ascites, higher MELD score and Patients with child score B, C.Conclusion Patients with cirrhosis and AVB have higher mortality rate, longer hospital LOS and re-hospitalization rate than those with NVB.
In vitro Screening Antiviral Activity of Thai Medicinal Plants Against Porcine Reproductive and Respiratory Syndrome Virus
Authors: Arjin Chaiwat , Pringproa Kidsadagon , Hongsibsong Surat , Ruksiriwanich Warintorn , Seel-audom Mintra , Mekchay Supamit , Sring Korawan
Published: January 2020

Background Porcine reproductive and respiratory syndrome (PRRS) caused by the PRRS virus (PRRSV) results in economic losses in the swine industry globally. Several studies have investigated the use of plant extracts for the prevention and control of PRRS outbreaks. Thai medicinal plants may be useful for treating PRRSV infection in pigs. Therefore, we investigated the in vitro anti-PRRSV and antioxidant properties of seven Thai medicinal plants: Caesalpinia sappan Linn., Garcinia mangostana Linn., Houttuynia cordata , Perilla frutescens , Clinacanthus nutans , Phyllanthus emblica , and Tiliacora triandra .Results In the antiviral screening test, we observed that the T. triandra extract strongly inhibited the infectivity of PRRSV into MARC-145 cells [virus titer 3.5 median tissue culture infectious doses (TCID 50 )/ml (log 10 )] at 24 h post-infection, whereas the C. sappan Linn. extract strongly inhibited PRRSV replication [virus titer 2.5 TCID 50 /ml (log 10 )] at 72 h postinfection. C. sappan Linn. extract had the highest total phenol content [220.52 mM gallic acid equivalents (GAE)/g] and the lowest half-maximal inhibitory concentration [IC 50 ; 1.17 mg/ml in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2.58 mg/ml in 2,2-azino-bis (3-ethylbenzothiazo-line-6-sulfonic acid) diammonium salt (ABTS)].Conclusion Our study showed that T. triandra could inhibit the infectivity of PRRSV, whereas C. sappan Linn was the most effective for inhibiting PRRSV replication in MARC-145 cells. This study elucidates the antiviral activities of Thai medicinal plant extracts in vivo . The result promising that the extracts of Thai medicinal plants, especially that of T. triandra and C. sappan Linn, can be developed into pharmaceutical drugs for the prevention of PRRS in pigs.
Nurse-led continuum of care for people with diabetes and pre-diabetes in Nepal (NUCOD): study protocol for a cluster randomized controlled trial
Authors: Xu Dong (Roman) , Dev Rubee , Shrestha Abha , Zhang Lingling , Shrestha Archana , Shakya Pushpanjali , Hughes James , Shakya Prabin , Li Jinghua , Liao Jing , Karmacharya Biraj
Published: January 2020

Background: The purpose of this study will be to improve diabetes prevention, access to care and advocacy through a novel cost-effective nurse-led continuum of care approach that incorporates diabetes prevention, awareness, screening and management for low-income settings, and furthermore utilizes the endeavor to advocate for establishing standard diabetes program in Nepal. Methods: We will conduct a two-arm, open-masked stratified cluster randomized controlled trial of a NU rse-led CO ntinuum of care for people with D iabetes (N1=200) and pre-diabetes (N2=1036) (NUCOD) , with primary care centers (9 Outreach Centers and 17 Government Health Posts) as a unit of randomization. NUCOD will be delivered through the trained diabetes nurses in the community to the intervention group and the outcomes will be compared to the enhanced usual-treatment group at 6 and 12 months of the intervention. The primary outcome will be change in glycated hemoglobin (HbA1c) level among diabetes and progression to type 2 diabetes among prediabetes, and implementation outcomes measured using the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework. Outcomes will be analyzed on an intention to treat basis. Discussion: The results of this trial will provide information about the effectiveness of the NUCOD program in improving clinical outcomes for diabetes and prediabetes individuals, and implementation outcomes for the organization. Trial registration: This study was registered in a clinical trials registry via ClinicalTrials.gov (NCT04131257) on 18 October 2019. https://bit.ly/34qwIAd
“Kunika women are always sick”: Views from community focus groups on short birth interval (kunika) in Bauchi State, Northern Nigeria
Authors: Ansari Umaira , Pimentel Juan , Omer Khalid , Gidado Yagana , Baba Mohd Chadi , Andersson Neil , Cockcroft Anne
Published: January 2020

Background In Northern Nigeria, short birth interval is common; the word kunika in the Hausa language describes a woman becoming pregnant before weaning her last child. A sizeable literature confirms an association between short birth interval and adverse perinatal and maternal health outcomes. Yet relatively little is known about how people view short birth interval and its consequences. In support of culturally-safe child spacing in Bauchi State, in North East Nigeria, we explored local perspectives about kunika and its consequences.Methods A qualitative descriptive study included 12 gender-segregated focus groups facilitated by local men and women in six communities from the Toro Local Government Area in Bauchi State. Facilitators conducted the groups in the Hausa language and translated the reports of the discussions into English. After an inductive thematic analysis, the local research team reviewed and agreed the themes in a member-checking exercise.Results Some 49 women and 48 men participated in the 12 focus groups, with an average of eight people in each group. All participants were married with ages ranging from 15-45 years. They explained their understanding of kunika , often in terms of pregnancy while breastfeeding. They described many disadvantages of kunika , including health complications for the mother and children, economic consequences, and adverse impact on men’s health and family dynamics. The groups concluded that some people still practise kunika , either intentionally (for example, in order to increase family size or because of competition between co-wives) or unintentionally (for example, because of frequent unprotected sex), and explained the roles of men and women in this.Conclusion Men and women in our study had a clear understanding of the concept of kunika . They recognized many adverse consequences of kunika beyond the narrow health concerns reported in quantitative studies. Their highlighted impacts of kunika on men’s wellbeing can inform initiatives promoting the role of men in addressing kunika .
Effect of Sequence Padding on the Performance of Protein-Based Deep Learning Models
Authors: Rio Angela Lopez-del , Martin Maria , Perera-Lluna Alexandre , Saidi Rabie
Published: January 2020

Background The use of raw amino acid sequences as input for protein-based deep learning models has gained popularity in recent years. This scheme obliges to manage proteins with different lengths, while deep learning models require same-shape input. To accomplish this, zeros are usually added to each sequence up to a established common length in a process called zero-padding. However, the effect of different padding strategies on model performance and data structure is yet unknown. Results We analysed the impact of different ways of padding the amino acid sequences in a hierarchical Enzyme Commission number prediction problem. Our results show that padding has an effect on model performance even when there are convolutional layers implied. We propose and implement four novel types of padding the amino acid sequences. Conclusions The present study highlights the relevance of the step of padding the one-hot encoded amino acid sequences when building deep learning-based models for Enzyme Commission number prediction. The fact that this has an effect on model performance should raise awareness on the need of justifying the details of this step on future works. The code of this analysis is available at https://github.com/b2slab/padding_benchmark.
Preparing for the delivery of PrEP: Lessons from the implementation of integrated reproductive health and HIV services in Kenya
Authors: Evens Emily McDonald , Hoke Theresa , Eichleay Margaret , Olsen Patrick , Olawo Alice , Githuka George
Published: January 2020

Background: In 2015, the WHO issued guidelines recommending oral pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV. Given their role in health service delivery, ministries of health are assuming major responsibility for PrEP services in sub-Saharan Africa. However, these are often strained and under-resourced. We measured the delivery of selected integrated services and identified the factors that impede effective delivery of integrated services to prepare for the integration of PrEP into health services for women. Methods: Three services were examined: 1) HIV testing within family planning, 2) HIV testing within general outpatient services, and 3) care and prevention services for HIV-positive clients not eligible for antiretrovirals (“Pre-ART”). Descriptive, mixed-methods research was conducted in three Kenyan counties using: service delivery observations (n = 3246) and client exit interviews (n = 3257) in public facilities, and semi-structured interviews with providers, managers and officials (n = 112). Results: Integrated services were not consistently implemented. HIV testing was not systematically offered or received; most clients were not aware testing was available, and tests were largely unavailable. Pre-ART services did not systematically deliver mandated services. Rates of cervical cancer and tuberculosis screening were especially low; a concerning gap given the elevated risk for HIV-positive women. Supply-side challenges of staffing, infrastructure and commodity shortages were common. Conclusions: In an era of significant demands on treatment resources and decreasing funding for prevention, the identification of the technical, material, and human resources required for successful and sustainable delivery of integrated services must be addressed to support successful PrEP implementation. Key words: Pre-exposure prophylaxis, Kenya, Integrated health, HIV
A comparison of intravenous remifentanil patient-controlled analgesia with combined spinal-epidural analgesia in multiparous women: a prospective observational study
Authors: Pintaric Tatjana Stopar , Zagar Tea , Semrl Neli , Umek Nejc , Lucovnik Miha , Velde Marc Van de , Blajic Iva
Published: January 2020

Background The combined spinal-epidural analgesia (CSEA) proved useful in multiparous women on account of faster onset and better analgesia in the first 30 minutes compared to standard epidural analgesia. Remifentanil has a suitable pharmacological profile for labour analgesia. Fast set up, onset, and limited time efficacy may render it useful in multiparous women with a faster labour progression.Methods The prospective observational study was performed in multiparous women in their active phase of the first stage labour after their informed choice of either RPCA (n=80) or CSEA (n=82). The primary outcome was pain-relief assessed on a 11-point numerical rating scale. The secondary outcomes were with pain-relief satisfaction, adverse effects, labour progress and labour outcomes.Results CSEA provided significantly lower pain scores and a higher satisfaction rate compared to RPCA [3.9 (0.36) vs 2.6 (1.1), P<0.001]. Likewise, more patients from the CSEA group would choose the same technique for the next labour CSEA; 77 (95%) vs. RPCA; 65 (81%), P=0.003. No difference between the groups was observed in recommending the respective technique to others CSEA; 77 (95%) vs. RPCA; 72 (90%), P=0.118. No crossovers were observed in either group. RPCA was associated with desaturation, bradypnea and apnoea in 27 (34%), 17 (21%) and 20 (25%) respective cases. All recovered spontaneously upon verbal or tactile stimulation. No clinically important differences were noted in sedation level, labour progress and labour outcomes between the groups.Conclusions This prospective observational study has shown that despite inferior pain relief and satisfaction, the remifentanil acceptance in multiparous women was still high as the vast majority of them graded their satisfaction rate as high/very high. That can be attributed to the facts that women with previewed shorter labour were more likely to choose a less invasive opioid analgesic option which provides an element of personal control. Thus, given no difference in labour outcomes, remifentanil could be routinely offered to parous women as a labour analgesic option, provided rigorous adherence to the protocols and continuous supervision by midwifes are ensured. Trial registration The trial was registered at ClinicalTrials.gov on November 15, 2016 (ID NCT02963337)
Design of a Modular Beam Control System for Vehicles
Authors: Chhirolya Vasu , Sachdeva Parv , Gudipalli Abhishek
Published: January 2020

High intensity beams enable the drivers to survey a large portion of the road ahead of them at night. These beams are meant for use when there aren’t many vehicles around. However, a lot of drivers make use of these beams while driving because of the convenience of having a larger field of view. These beams often result in momentary partial blindness for drivers in the oncoming lane, causing them to become floundered. In such a state, they tend to lose control and cause accidents. In this paper, we propose a novel method to curb such happenings by automating the high beam and low beam settings of a vehicle. For the purpose of this study, we used a custom prototype, which is also discussed in detail. The solution we propose, if developed into a product, would be available as an add-on module, and if implemented appropriately, will reduce the accidents due to headlight glare by an exponential factor.
Evaluation of consciousness: the FOUR scale or the Glasgow coma scale? Review
Authors: Belkin Andrey A. , Bochkarev P. Yu. , Levit A. L. , Zabolotskikh Igor B.
Published: January 2020

Assessing the level of consciousness is one of the key competencies of medical workers involved in the provision of emergency care. For 45 years, the Glasgow Coma Scale has been used for this, which has the highest level of interdisciplinary consistency and reproducibility, for which it was recognized as the gold standard for assessing consciousness when patients are admitted to the intensive care unit. But along with the advantage of simplicity and extensive experience in application, it has a number of significant drawbacks. In particular, the impossibility of verbal contact in intubated patients, the presence of motor aphasia and delirium deliberately reduces the score in the speech section, which is fraught with an underestimation of the overall assessment of the level of consciousness. It is also significant that GCS does not evaluate brain stem reflexes, eye movements, or complex motor reactions, which excludes the possibility of a reliable assessment of the condition of a patient with subtentorial damage and in a state of chronic impaired consciousness.
As our own experience and preliminary analysis of the literature showed, these shortcomings are absent in the Full Outline of UnResponsiveness (FOUR) scale developed by FM Wijdicks at the Mayo Clinic in 2005. The spread of the FOUR scale in many countries and the growing need for effective monitoring of patients with acute cerebral injury motivated Federation of anesthesiologists of Russia (FAR) to initiate a multicenter study. The purpose of the study: validation, assessment of reproducibility and consistency of the results of using the Russian-language version of the FOUR scale for multidisciplinary use in patients with impaired consciousness. Prospective cohort nonrandomized study is completed at three centers that routinely use this scale in their practice for several years (“FOUR-Rus” NCT04018989 ClinicalTrials.gov).
Dexmedetomidine sedation experience in hybrid cardiac operations. Article
Authors: Gruzdev Kirill A. , Margolina A. A. , Tabak’yan E. A. , Lepilin M. G.
Published: January 2020

Background. Dexmedetomidine sedation can appear effective anesthesiological management in hybrid cardiac operations.
Objectives. To examine the safety use of dexmedetomidine sedation in hybrid cardiac operations.
Material and Methods. This study includes 132 patients, who underwent hybrid cardiac operations. Patients were randomized into dexmedetomidine (DEX) and general anesthesia (GA) use groups. We evaluated hemodynamics, gas exchange measurements, postoperative complications as primary outcomes of the study.
Results. In DEX group greater hemodynamics stability occured, which reflected in higher systolic (p < 0,0001) and mean arterial pressure (p = 0,019) compared to GA. Significantly lower usage of cathecholamines was defined in DEX versus GA (p = 0,033). The depth of sedation in DEX seemed to be adequate in assessing with RASS and Ramsay score. In DEX we observed highest value of carbon dioxide in arterial blood gas versus GA (47.0 vs 39.0, respectively), with no significant difference in oxygen concentration. Frequency of COPD was significantly higher in DEX group. Higher incidence of postoperative delirium (p = 0,041) was noted in GA (15 %) versus DEX (3,5 %). There was no significant difference in frequency of AKI, renal replacement therapy, stroke, respiratory complications in observed groups. In DEX group GFR values appeared much better than in GA group (p = 0,02).
Conclusions. In hybrid cardiac operations sedation with dexmedetomidine provides hemodynamics stability. Dexmedetomidine set up good anesthesia conditions with adequate gas exchange parameters, that is usefull in patients with COLD. Applying dexmedetomidine, the frequency of postoperative delirium may be reduced. Dexmedetomidine can improve glomerular filtration rate values.
Transport fluctuations in integrable models out of equilibrium
Authors: Myers Jason , Bhaseen Joe , Harris Rosemary J. , Doyon Benjamin
Published: January 2020

We propose exact results for the full counting statistics, or the scaled cumulant generating function, pertaining to the transfer of arbitrary conserved quantities across an interface in homogeneous integrable models out of equilibrium. We do this by combining insights from generalised hydrodynamics with a theory of large deviations in ballistic transport. The results are applicable to a wide variety of physical systems, including the Lieb-Liniger gas and the Heisenberg chain. We confirm the predictions in non-equilibrium steady states obtained by the partitioning protocol, by comparing with Monte Carlo simulations of this protocol in the classical hard rod gas. We verify numerically that the exact results obey the correct non-equilibrium fluctuation relations with the appropriate initial conditions.
Possibilities of applying speckle tracking echocardiography to assess fetal
myocardial function. Part 1. Methods to assess fetal cardiac function
Authors: S.I. Buryakova, M.V. Medvedev
Published: January 2020

The article deals with the physiology of the heart and methods to assess fetal cardiac function. The leadingedge technique to assess the myocardial deformation properties by speckle tracking echocardiography in prenatal
period is presented.
Ventricular diverticulums/aneurysms of the fetal heart: the first
experience to assess the myocardial deformation properties using speckle
tracking echocardiography
Authors: S.I. Buryakova , M.V. Medvedev , A.I. Zamyatina et all
Published: January 2020

The article is presents the possibilities to assess the myocardial deformation properties using speckle tracking
echocardiography in 3 fetuses with diverticula/ventricular aneurysms.
Case report of umbilical vein thrombosis
Authors: V.M. Bolotskih, E.R. Semenova
Published: January 2020

A case of umbilical vein thrombosis is presented. Thrombotic masses were detected inside umbilical vein
during ultrasound examination on the gestation age 40 weeks and 4 days. Such serious complication probably
caused by decompensation of chronic placenta insufficiency in post-term pregnancy. In result reduce blood
speed and forming thrombus inside umbilical vein
Оценка гемосовместимости наноструктурированных сфер гидроксиапатита различного размера
Authors: Захарова О. В. , Васюкова И. А. , Гусев А. А. , Чупрунов К. О. , Юдин А. Г. , Кузнецов Д. В.
Published: January 2020

Синтетический наноструктурированный гидроксиапатит перспективен для широкого спектра задач восстановительной медицины и имплантологии, а также в косметологии и стоматологии. Меняя условия синтеза, для каждого конкретного направления применения можно регулировать характеристики материала в соответствии с поставленной задачей. Методом химического осаждения с последующей распылительной сушкой с ультразвуковой обработкой получены образцы наноструктурированного гидроксиапатита с различным составом и размером гранул. Анализ гемосовместимости материалов в экспериментах с мононуклеарными лейкоцитами и эритроцитами крови мыши показал, что полученные образцы гранул в концентрации 40 мг на 2 мл клеточной взвеси являются гемосовместимыми по всем исследуемым показателям независимо от размера и состава сфер.
Наноструктурирование и создание нанокомпозитов — перспективное направление увеличения эффективности термоэлектриков
Authors: Кульбачинский В. А.
Published: January 2020

Приведены данные о термоэлектрической эффективности различных материалов: наноструктурированных поликристаллических; нанокомпозитов с проводящими наночастицами второй фазы; нанокомпозитов с наночастицами диэлектрика, нанокомпозитов с наночастицами второго термоэлектрика. Описано влияние наноструктурирования и создания нанокомпозитов теллурида висмута (Bi2 Te3 ) и теллурида сурьмы (Sb2 Te3 ) с графитом на термоэлектрические свойства этих материалов.
Применение наночастиц золота для высокочувствительного поляризационного флуоресцентного аптамерного анализа охратоксина А
Authors: Самохвалов А. В. , Сафенкова И. В. , Еремин С. А. , Жердев А. В. , Дзантиев Б. Б.
Published: January 2020

Предложено применение наночастиц золота (НЧЗ) в качестве носителей для снижения предела обнаружения поляризационного флуоресцентного (ПФ) аптамерного анализа. ПФ-анализ основывается на различиях флуорофора, конъюгированного с аналитом и облучаемого плоскополяризованным светом, по степени деполяризации излучаемого света до и после связывания аналита с рецептором. Применение аптамеров в качестве рецепторов в таком анализе ограничено из-за их небольшой молекулярной массы и соответственно недостаточного влияния на поляризацию. Данное ограничение может быть устранено посредством включения аптамеров в крупные межмолекулярные комплексы. Показаны преимущества НЧЗ как унифицированного, стабильного и легкомодифицируемого носителя для аптамеров. ПФ-аптамерный анализ реализован с применением НЧЗ, имеющих средний диаметр 8.7 нм, и охратоксина А (ОТА) в качестве целевого аналита. Анализ апробирован для тестирования проб белого вина. Достигнутый предел обнаружения ОТА — 2.3 мкг/кг, что в 25 раз ниже, чем при использовании нативного аптамера. Продолжительность анализа — 15 мин. Предлагаемый подход может применяться для аптамерного анализа различных низкомолекулярных соединений.
Treatment of folic acid wastewater by 3D Fe-N-TiO2/AC photoelectrocatalysis system
Authors: Zhou Junwo , Zhou Zhen , Gao Yong , Li Tingting , Zhang Manying , Fu Xiaofei , Liu Fang
Published: January 2020

In this work, particles of activated carbon supported by Fe-N-TiO2 (Fe-N-TiO2/AC) were synthesized and used as the three-dimensional (3D) particle electrode for folic acid wastewater treatment in the 3D electrolysis and photocatalysis coupling process. The structure, morphology, and physical and electrochemical properties of the Fe-N-TiO2/AC particles were characterized, and the results showed that Fe-N-TiO2 was bound on the surface of AC particles by chemical attachment, and the Fe-N-TiO2/AC particles had better capability of adsorption and charge transfer as compared with the TiO2/AC particles. The effects of key operating parameters in the reaction process, including the current density (optimum 0.6 mA/cm2), aeration (optimum 5 L/min), pH value (optimum 5) and the ratio of Fe-N-TiO2/AC particles to cellulose acetate film coating AC particles (optimum 4:1), were optimized regarding the total oxygen carbon (TOC) removal. Under the optimum conditions, TOC removal from folic acid wastewater reached 82.4% during 120 min photoelectrocatalysis. The kinetic analysis and mechanism study showed that the degradation process fitted to the second-order kinetic model better than to the first-order, and the system exhibited synergistic effects in inhibiting photogenic electron–hole recombination and improving electrolytic efficiency. At the same time, this system has the ability to overcome the interference of the strong ionic strength in folic acid wastewater.
BİST Şehir Endeksleri ile Döviz Kurları Arasındaki İlişkinin İncelenmesi: Bir ARDL Sınır Testi Uygulaması
Authors: Kayral İhsan Erdem
Published: January 2020

Bu çalışmanın amacı, Borsa İstanbul (BİST) Şehir Endeksinde yer alan BİST İstanbul, BİST Ankara ve BİST İzmir Şehir Endeksi ile Dolar ve Euro arasında 01.07.2009 – 01.07.2019 döneminde kısa ve uzun dönemli ilişkilerin incelenmesidir. Çalışma kapsamındaki modellerde değişkenlerin kapanış fiyatlarının doğal logaritmaları kullanılmıştır. Şehir Endeksleri ile döviz kurları arasındaki ilişkiler ARDL modeli ile incelenmiştir. Ampirik çalışma sonuçlarına göre, tüm modellerde Şehir Endeksleri ile döviz kurları arasında (BİST Ankara ile Euro ilişkisi hariç) eşbütünleşme bir başka deyişle uzun dönemli ilişki bulunmuştur. Kısa dönemde ise gecikmesiz değerlerde yalnızca İzmir Şehir Endeksi ile Euro arasında pozitif yönlü ilişki tespit edilmiştir.
Computer-aided Drug Design Investigations for Benzothiazinone Derivatives Against Tuberculosis
Authors: Viana Jéssika O. , Scotti Marcus T. , Scotti Luciana
Published: January 2020

Background:

Tuberculosis (Mycobacterium tuberculosis) is an infectious bacterial disease with
the highest levels of mortality worldwide, presenting numerous cases of resistance. In silico studies, which
elaborate chemical and biological models in computational tools and make it possible to interpret
molecular characteristics, are among the methods used in the search for new drugs.

Objective:

In this perspective, our aim was to use QSAR and molecular modeling to propose possible
pharmacophores from benzothiazinone derivatives.

Methods:

In this study, a set of 69 benzothiazinone derivatives, together with computational tools such as
molecular descriptor analysis in chemometrics, metabolic prediction, and molecular coupling to 4
proteins: DprE1, InhA, PS, and DHFR important for the bacillus were investigated.

Results:

The chemometric model computed in the Volsurf+ program presented good predictive values for
both amphiphilicity and molecular volume. These are essential for biological activity. Metabolites from
the cytochrome isoforms CYP3A4 and 2D6 interactions revealed coupling divergences which, noting that
the metabolites did not present changes to the QSAR proposed pharmacophore structures, may be due to
the reaction medium and existing differences in the benzothiazinone structures. Similarly, molecular
docking with the four TB enzymes presented good interactions for the more active compounds. The
fragments found using QSAR (being essential for biological activity) also presented as being essential for
ligand-protein site interactions.

Conclusion:

From the benzothiazinone derivative series evaluated, compound 11026134 presented the
best profile in all study analyses, noting that the trifluoromethyl, nitro group, and piperazine fragment with
aliphatic hydrocarbon groups are likely pharmacophores for the benzothiazinones studied.
Withdrawal Notice: Computational Druglikeness Assessment, Synthesis, Characterization and In vitro Biological Activity Evaluation of some Novel Mixed Metal Complexes of 2-(butan-2-ylidene) Hydrazinecarbothioamide
Authors: Khan Tahmeena , Azad Iqbal , Lawrence Alfred J. , Raza Saman , Joshi Seema , Khan Abdul Rahman
Published: January 2020

The article has been withdrawn at the request of the authors of the journal "Combinatorial Chemistry & High Throughput
Screening".

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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The Relationship of Mother's Spiritual Well-being and Forgiveness with Mother-to-infant Attachment in Women Referring to Maternity Hospital Affiliated to Shiraz University of Medical Sciences
Authors: Dehestani Hanieh , Moshfeghy Zeinab , Ghodrati Fatemeh
Published: January 2020

Background:

The mental health of the mother has a great influence on the health of her
fetus.

Objective:

The aim of this study was to investigate the relationship between the mother's spiritual
well-being and forgiveness with maternal-fetal attachment (MFA).

Methods:

This is a descriptive-analytic cross-sectional study. A sample of 200 female participants
was selected by applying a simple sampling method among the mothers hospitalized in 3 clinics
during the period of 2017-2018. The Paloutzian and Ellison Spiritual Health and Pollard & Anderson
Forgiveness Questionnaires were used toassess the correlation between the spiritual health and
forgiveness of the mother with MFA.

Results:

The relationship between attachment parameters including sentimental and emotional behaviors
(r = 0.365, p = 0.0001), near-proximity-keeping behaviors (r = 0.261, p = 0.002), care behaviors
(r = 0.339, p = 0.0001), mother’s attention to baby (r = 0.19, p = 0.026), versus all attachment
behaviors (r = 0.349, p = 0.0001) and high level of spiritual well-being was significant,
whereas the relationship between the mother’s forgiveness score and all the attachment components
was not meaningful. However, the high level of forgiveness score was significant with all of the
attachment components (p<0.0001).

Conclusion:

There was a significant relationship between the mother’s mental health and forgiveness
and the attachment versus its components. It is recommended that in order to reduce the stress
level and promotion of MFA, training courses for spiritual programs and mechanisms for the creation
of forgiveness should be scheduled in the pregnancy plans.
Combined High Throughput Screening with QSAR Analysis Unravelling Potential Glyoxalase-I Inhibitors
Authors: Al-Sha’er Mahmoud A. , Al-Balas Qosay A. , Hassan Mohammad A.
Published: January 2020

Aims:

Discovery of new Glo-I inhibitors as potential anticancer agents.

Background:

Glyoxalase system is ubiquitous system in human cells which has been examined
thoroughly for its role in cancerous diseases. It performs detoxifying endogenous harmful metabolites,
mainly methylglyoxal (MG) into non-toxic bystanders.

Objective:

Structure based model Hypo(2ZA0_2_02) combined with 3D-QSAR modeling were
applied to predict glyoxalase I inhibition and to explain their activity.

Methods:

Currently, high throughput screening approach was used to investigate the activity of inhouse
database composed of 205 compounds.

Result:

15 compounds were found active as glyoxalase I inhibitors. The 15 candidates showed
more than 50% inhibition with low micromolar IC50 ranges between 5.0 to 42.0 μM.

Conclusion:

They have been successfully mapped and fitted the Hypo(2ZA0_2_02) model which
explain the presence of anti-glyoxalase I activity.
This model could be used in future for further development of new and novel glyoxylase I inhibitors.
Screening of SLE-susceptible SNPs in One Chinese Family with Systemic Lupus Erythematosus
Authors: Luo Juan , Meng Yanming , Zhai Jianzhao , Zhu Ying , Li Yizhou , Wu Yongkang
Published: January 2020

Background:

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, which mainly affects childbearing-aged women. Although its pathogenesis is not fully clear yet, studies have shown that genetic factors are vital in exploring SLE pathogenic mechanisms.

Objective:

The purpose of this study is to predict and screen potential pathogenic single nucleotide polymorphisms (SNPs). By comparing the genomes of members of a family with SLE and performing functional analysis on mutation loci, possible pathogenic polymorphisms are screened. These analyses lay the foundation for further research mechanisms.

Method:

Genomic alignment, variant calling and functional annotation were performed and then ~92,778 original SNPs were obtained for each specimen. We found that the patient/healthyspecific SNPs show different conservative score distribution. Many patient-specific SNPs were detected in SLE-related pathways. We therefore investigated the patient-specific SNPs from four diverse perspectives, including nonsynonymous variations in exon regions, expression quantitative trait loci (eQTLs), RNA binding sites and RNA-binding protein (RBP) binding sites.

Results:

18 potential pathogenic SNPs were identified in SLE risk genes, which were associated with functional loci. Systematic literature study was then performed to verify these potential pathogenic SNPs.

Conclusion:

This study could help to better explain possible genetic mechanisms of SLE from the perspective of variation. It could provide effective strategy for the accurate diagnosis and personalized treatment of SLE patients.
Therapeutic Potentials and Mechanisms of Artemisinin and its Derivatives for Tumorigenesis and Metastasis
Authors: Li Yue , Zhou Xiaoyan , Liu Jiali , Yuan Xiaohong , He Qian
Published: January 2020

Background:

Tumor recurrence and metastasis are still leading causes of cancer mortality worldwide. The influence of traditional treatment strategies against metastatic tumors may still be limited. To search for novel and powerful agents against tumors has become a major research focus. In this study, Artemisinin (ARM), a natural compound isolated from herbs, Artemisia annua L., proceeding from drug repurposing methods, attracts more attention due to its good efficacy and tolerance in antimalarial practices, as well as newly confirmed anticancer activity.

Methods:

We have searched and reviewed the literatures about ARM and its derivatives (ARMs) for cancer using keywords "artemisinin" until May 2019.

Results:

In preclinical studies, ARMs can induce cell cycle arrest and cell death by apoptosis etc., to inhibit the progression of tumors, and suppress EMT and angiogenesis to inhibit the metastasis of tumors. Notably, the complex relationships of ARMs and autophagy are worth exploring. Inspired by the limitations of its antimalarial applications and the mechanical studies of artemisinin and cancer, people are also committed to develop safer and more potent ARM-based modified compounds (ARMs) or combination therapy, such as artemisinin dimers/ trimers, artemisinin-derived hybrids. Some clinical trials support artemisinins as promising candidates for cancer therapy.

Conclusion:

ARMs show potent therapeutic potentials against carcinoma including metastatic tumors. Novel compounds derived from artemisinin and relevant combination therapies are supposed to be promising treatment strategies for tumors, as the important future research directions.
Stingless Bee Honey Reduces Anxiety and Improves Memory of the Metabolic Disease-induced Rats
Authors: Arshad Nurul ‘Ain , Lin Teoh Seong , Yahaya Mohamad Fairuz
Published: January 2020

Background:

Scientific studies support the evidence of the involvement of Metabolic Syndrome
(MetS) in the progression of neurodegenerative diseases through oxidative stress. Consumption
of antioxidant compounds was found to be beneficial for brain-health as it reduced the brain oxidative
stress level and improved cognitive performance in animals. Stingless bee honey or locally known as
Kelulut Honey (KH) has high phenolic content and is widely used as a food supplement.

Objectives:

In this study, we aimed to investigate the effects of KH on the brain of MetS-induced rats.

Methods:

Forty male Wistar rats were divided into 5 groups; 8 weeks (C8) and 16 weeks control
groups (C16), groups that received High-Carbohydrate High Fructose (HCHF) diet for 8 weeks (MS8)
and 16 weeks (MS16), and a group that received HCHF for 16 weeks with KH supplemented for the
last 35 days (KH).

Results:

Serum fasting blood glucose decreased in the KH group compared to the MS16 group. HDL
levels were significantly decreased in MetS groups compared to control groups. Open field experiments
showed that KH group exhibits less anxious behavior compared to the MetS group. Probe trial
of Morris water maze demonstrated significant memory retention of KH group compared to the MS16
group. Nissl staining showed a significant decrease in the pyramidal hippocampal cells in the MS16
compared to the KH group.

Conclusion:

KH has the ability to normalise blood glucose and reduce serum triglyceride and LDL
levels in MetS rats, while behavior studies complement its effect on anxiety and memory. This shows
a promising role of KH in attenuating neurodegenerative diseases through the antioxidant activity of
its polyphenolic content.