bluuebunny/crossref_metadata_2025 huggingface dataset:
Pulsed Light Application for Campylobacter Control on Poultry Meat and Its Effect on Colour and Volatile Profile
Authors: Baptista Esther , Borges Ana , Aymerich Teresa , Alves Susana P. , Gama Luís Telo da , Fernandes Helena , Fernandes Maria José , Fraqueza Maria João
Published: September 2022

Campylobacter on poultry meat needs to be controlled to reduce the risk of infection caused by the consumption of chicken meat. Pulsed light (PL) application on poultry meat was studied to control Campylobacter spp. The effect of this technology was evaluated regarding poultry meat colour and volatile compound changes. Two breast sample groups were prepared: inoculated with Campylobacter (107 bacteria of Campylobacter jejuni strains) and not inoculated. Samples were submitted to PL, five pulses/s of 300 ms, 1 Hz, and 1 J/cm2 in the apparatus, PL Tecum unit (Claranor). A response surface experimental design was applied regarding the factors of voltage (1828 to 3000 W) and distance to the source UV lamp (2.6 to 5.4 cm). The binomial factorial treatment (voltage and distance) with PL induced different energy doses (fluence J/cm2) received by samples, 2.82 to 9.67 J/cm2. Poultry meat pulsed light treated had a significant decrease of Enterobacteriaceae counts. The treatments applied were unable to reduce 1 log Campylobacter cfu/g of poultry meat. The poultry meat PL treated became slightly light, redder, and yellower than those not treated. PL can decrease the proportion of aldehydes on total volatiles in meat, particularly on those associated with chicken-like, chicken skin-like, and sweet odour notes in fresh poultry meat. Further studies of PL with higher energy doses will be necessary to confirm if there are Campylobacter reductions and about poultry meat treated under storage to evaluate if volatile compounds can affect the flavour of PL-treated meat samples.
Consumer Behaviour and Attitude towards the Purchase of Organic Products in Riobamba, Ecuador
Authors: Ayaviri-Nina Víctor Dante , Jaramillo-Quinzo Nataly Sthefania , Quispe-Fernández Gabith Miriam , Mahmud Ilias , Alasqah Ibrahim , Alharbi Talal Ali F , Alqarawi Nada , Carrascosa Conrado , Saraiva Ariana , Alfheeaid Hani A. , Raposo António
Published: September 2022

The development of organic agriculture has been promoted worldwide to improve the nutritional health of families, and Ecuador is no exception. The aim of this research was to identify the behaviour and attitudes of consumers toward the commercialization of organic products in the city of Riobamba. This will help us to understand in what situations the consumers access these foods, the producer position in relation to the market, and to know their attitude towards these products. The study used a quantitative approach, and is descriptive, incorporating the deductive method and a non-experimental design. The techniques used were a survey as a source of data collection, with a sample including 195 consumers. Linear regression was applied to test the hypotheses; this made it possible to identify those demographic and cultural factors that determine, to a lesser extent, consumer purchase behaviour in regard to organic products. The study determined that motivation, emotions, and feelings are significantly related to the consumer’s attitude and purchase of organic products.
Some H-Godunova–Levin Function Inequalities Using Center Radius (Cr) Order Relation
Authors: Afzal Waqar , Abbas Mujahid , Macías-Díaz Jorge E. , Treanţă Savin
Published: September 2022

Interval analysis distinguishes between different types of order relations. As a result of these order relations, convexity and nonconvexity contribute to different kinds of inequalities. Despite this, convex theory is commonly known to rely on Godunova–Levin functions because their properties make it more efficient for determining inequality terms than convex ones. The purpose of this study is to introduce the notion of cr-h-Godunova–Levin functions by using total order relation between two intervals. Considering their properties and widespread use, center-radius order relation appears to be ideally suited for the study of inequalities. In this paper, various types of inequalities are introduced using center-radius order (cr) relation. The cr-order relation enables us firstly to derive some Hermite–Hadamard (H.H) inequalities, and then to present Jensen-type inequality for h-Godunova–Levin interval-valued functions (GL-IVFS) using a Riemann integral operator. This kind of convexity unifies several new and well-known convex functions. Additionally, the study includes useful examples to support its findings. These results confirm that this new concept is useful for addressing a wide range of inequalities. We hope that our results will encourage future research into fractional versions of these inequalities and optimization problems associated with them.
On Variation Mechanisms in Recurrent Nova IM Normae
Authors: Wilson R. E.
Published: September 2022

Light curves by Woudt and Warner (WW) of recurrent nova IM Nor show eclipse-like dips that they saw as too wide for eclipses alone, and interpreted as mainly a reflection effect due to irradiation of the companion (mass donor) star with some amplitude increase due to eclipse of IM Nor’s disk. A mainly reflection interpretation cannot be made to work because reflection does not produce dips over a restricted phase range but a somewhat distorted sinusoid that extends over the entire orbital cycle. Here, the dip features are interpreted in two ways, with testing via quantitative light curve modeling that includes an equipotential disk. One way is as alternating eclipses of and by the disk that surrounds this cataclysmic variable’s accreting white dwarf, rather than purely a succession of disk-by-star eclipses. WW’s estimated period of 0.d1026 was accordingly doubled to 0.d2052, with the observed dips now half of their previous width in phase, and with the modeled eclipses matching the observed dips in width and shape. In the 2nd interpretation, a toroidal disk’s capability to produce very wide eclipses is demonstrated computationally. Furthermore, much of the perceived eclipse width can be recognized as an apparent effect due to tidal stretching of the companion star and the disk. In overview, disk eclipses and tidal variation combine with reflection to produce a light curve waveform of approximately the observed shape and duration. Eclipses, tides, and reflection all have essential roles in the 2nd interpretation and no change from WW’s period is needed. Radial velocity observations will be crucial for identification of the correct resolution of the ”excessively wide eclipse” problem.
Relationship between Psychological Distress and Demographic Characteristics among Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery
Authors: Zaini Noor Hanita , Abdullah Khatijah Lim , Raja Mokhtar Raja Amin , Chinna Karuthan , Kamaruzzaman Shahrul Bahyah
Published: September 2022

Coronary artery bypass graft (CABG) surgery patients often present with anxiety and depression. These symptoms coupled with pain are major concerns and are widely reported among CABG patients. The study aimed to evaluate the relationship between psychological distress and patients’ demographic data. This cross-sectional study in which 178 patients from a surgery ward were selected using the census method. Data were collected using the Hospital Anxiety and Depression Scale and the Brief Pain Inventory (Short Form). The participants’ mean age was 57.49 ± 13.78 years. The majority of participants had a moderate level of anxiety (89.3%) and a moderate level of pain interference (74.7%). Significant differences were noted, with a higher proportion of moderate anxiety level participants aged between 60 and 74 years old, married, and with a tertiary level education (p < 0.05) being found. There were also significant differences between gender (p < 0.05) and pain severity (p < 0.01) across the levels of depression. The levels of anxiety, depression, and pain were significant, especially among older patients. These symptoms should be routinely assessed, and further identification of predictors such as socioeconomic status before the procedure is necessary.
Occupational Therapy Interventions for Dementia Caregivers: Scoping Review
Authors: Martínez-Campos Alberto , Compañ-Gabucio Laura-María , Torres-Collado Laura , Garcia-de la Hera Manuela
Published: September 2022

Background and purpose: caregivers of people with dementia (PwD) often experience a significant caregiver burden. Occupational Therapy (OT) is a helpful discipline for improving quality of life and other health factors for these caregivers. We conducted a Scoping Review to describe OT interventions for caregivers of PwD. Methods: two authors searched PubMed, Scopus, EMBASE and Web of Science databases and OT journals indexed in the Journal Citation Reports. Terms included in the search strategy were: dementia, Alzheimer, Parkinson, caregivers and OT. We included articles with experimental design in which an OT intervention in caregivers of PwD was carried out, written in Spanish or English and with the full text available. Results: a total of 2121 articles were obtained, 31 of which were included; 22 of them described home-based OT interventions: Tailored Activity Program (TAP) (n = 5), Environmental Skill-Building Program (ESP) (n = 4) and Advancing Caregiver Training (ACT) (n = 3) and other household interventions (n = 10); the remaining studies described OT interventions in other settings (n = 9). Conclusions: OT interventions for caregivers of PwD were mainly carried out at home. The most commonly used interventions were TAP focused on caregivers of people with Alzheimer’s disease, aimed at lessening the burden, depression and stress experienced by caregivers.
Ventilator-Associated Pneumonia Caused by Multidrug-Resistant Gram-Negative Bacteria in Vietnam: Antibiotic Resistance, Treatment Outcomes, and Colistin-Associated Adverse Effects
Authors: Vo Thu Pham Minh , Dinh Thien Chi , Phan Hung Viet , Cao Thuy Thi My , Duong Phuoc Thien , Nguyen Thang
Published: September 2022

Background: Ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) gram-negative bacteria (GNB) presents a serious clinical scenario, and there is disagreement regarding the role of colistin in treatment. This study aimed to characterize the antibiotic resistance of MDR GNB and evaluate the treatment outcomes and side effects of colistin in VAP patients caused by MDR GNB, particularly in Vietnam. Methods: A prospective cohort research was undertaken. We enrolled 136 intubated patients diagnosed with VAP according to the Centers for Disease Control and Prevention (CDC) 2019. Sixty-six individuals with an isolated gram-negative bacterium (Acinetobacter baumannii, Klebsiella pneumoniae, or Pseudomonas aeruginosa) satisfied the European Centre for Disease Prevention and Control (ECDC)’s criteria for multi-antibiotic resistance. Results: GNB resistance was categorized as 10.6% MDR, 63.6% XDR, and 25.8% PDR. GNB were resistant to β-lactams 80–100%, aminoglycosides 50–86.7%, fluoroquinolones 100% and colistin 2.8–20%. The 28-day mortality rate was 54.5%, and acute kidney injury occurred at 12.1%. There was no statistically significant difference in mortality rate between groups receiving regimens with or without colistin (58.3% and 73.3%, respectively; OR = 1.964; 95%CI 0.483–7.989). Neither was there a statistically significant difference in acute renal damage rate between groups receiving regimens with or without colistin (14.3% and 9.7%, respectively; OR = 1.556; 95%CI 0.34–7.121). Conclusions: GNB had a high rate of antibiotic resistance to most antibiotics. The addition of colistin to the medication did not show significant differences in renal toxicity or mortality, while colistin resistance was relatively low; larger studies need to be conducted.
Effects of Carbonated Thickened Drinks on Pharyngeal Swallowing with a Flexible Endoscopic Evaluation of Swallowing in Older Patients with Oropharyngeal Dysphagia
Authors: Morishita Motoyoshi , Okubo Masahiko , Sekine Tatsuro
Published: September 2022

This study aimed to determine the efficacy of carbonated and sweetened drinks added to thickened liquids, which are routinely used for patients with dysphagia to improve dysphagia. Patients swallowed thin liquid (Thin), thickened liquid (Thick), carbonated thin drink (C-Thin), and carbonated thickened drink (C-Thick) in random order. Penetration and/or aspiration were scored using the Penetration–Aspiration Scale (PAS). The residue was scored using the Yale Pharyngeal Residue Severity Rating Scale (YPR-SRS). Swallowing reflex initiation was scored using the Hyodo score. The subjective difficulty of swallowing was scored on a face scale. We analyzed 13 patients with a mean age of 79.6 ± 9.6 years. PAS was significantly lower in the C-Thick group than the Thin group (p < 0.05). Swallowing reflex initiation was significantly different between the Thin and Thick (p < 0.01) groups; moreover, post hoc analysis revealed that it was significantly lower in the C-Thick group than the Thin group (p < 0.01). The subjective difficulty of swallowing in the C-Thick was significantly lower than the Thick group (p < 0.05). C-Thick was easier to swallow than Thick and may improve penetration and/or aspiration in older patients with dysphagia with complex diseases.
Coping Strategies and Perceiving Stress among Athletes during Different Waves of the COVID-19 Pandemic—Data from Poland, Romania, and Slovakia
Authors: Makarowski Ryszard , Predoiu Radu , Piotrowski Andrzej , Görner Karol , Predoiu Alexandra , Oliveira Rafael , Pelin Raluca Anca , Moanță Alina Daniela , Boe Ole , Rawat Samir , Ahuja Gayatri
Published: September 2022

Coronavirus disease (COVID-19), an infectious disease caused by the SARS-CoV-2 virus, has affected numerous aspects of human functioning. Social contacts, work, education, travel, and sports have drastically changed during the lockdown periods. The pandemic restrictions have severely limited professional athletes’ ability to train and participate in competitions. For many who rely on sports as their main source of income, this represents a source of intense stress. To assess the dynamics of perceived stress as well as coping strategies during different waves of the COVID-19 pandemic, we carried out a longitudinal study using the Perception of Stress Questionnaire and the Brief COPE on a sample of 2020 professional athletes in Poland, Romania, and Slovakia. The results revealed that in all three countries, the highest intrapsychic stress levels were reported during the fourth wave (all, p < 0.01) and the highest external stress levels were reported before the pandemic (p < 0.05). To analyze the data, analyses of variance were carried out using Tukey’s post hoc test and η2 for effect size. Further, emotional tension was the highest among Polish and Slovak athletes in the fourth wave, while the highest among Romanian athletes was in the pre-pandemic period. The coping strategies used by the athletes in the fourth wave were more dysfunctional than during the first wave (independent t test and Cohen’s d were used). The dynamics of the coping strategies—emotion focused and problem focused—were also discussed among Polish, Romanian, and Slovak athletes. Coaches and sports psychologists can modify the athletes’ perceived stress while simultaneously promoting effective coping strategies.
Transcriptome Analysis of Berries of Spine Grape (Vitis davidii Föex) Infected by Colletotrichum viniferum during Symptom Development
Authors: Lei Yan , Yuan Xiaojian , Chen Ting , Yuan Yuan , Liu Xinming , Tang Xinbiao , Chen Qingxi
Published: September 2022

Grape ripe rot (Colletotrichum viniferum) causes huge losses in grape production in vineyards in southern China. However, the molecular mechanism against ripe rot in grape species and the responsive genes implicated in these processes are relatively unknown. Here, we present the transcriptome analysis of berries from a C. viniferum-resistant species (Vitis davidii Föex). Uninfected berries at day zero were used as control samples (CK), an inoculation was made at day zero, and the berries were subsequently analyzed at 1 day, 3 days, and 7 days post inoculation (dpi), which exhibited a sequential disease-progression stage. There were a total of 1810 differentially expressed genes, including 1315 up-regulated and 495 down-regulated transcripts. At 7 dpi, these differentially expressed genes (DEGs) were predominantly enriched in berries. In addition, in C. viniferum-infected grape fruits at 7 dpi, considerable changes in gene expression were induced, and those up-regulated genes involved in MAPK cascade, calcium ion binding, and serine/threonine kinase activity were enriched. According to our KEGG pathway analysis, numerous enriched biological processes, such as plant–pathogen interaction, phenylpropanoid biosynthesis, and metabolism, were implicated in grape–fungus interactions. Our research also revealed alterations in the expression pattern of phenylalanine-pathway-related transcription factors (TFs) and genes. We proposed a model in which C. viniferum invasion produces intracellular and extracellular Ca2+ deregulation to stimulate the MAPK pathway to activate TFs’ (WRKY, ERF, and MYB) up-regulation, thus initiating disease-resistant responses in the tolerant Vitis species. Our results offer comprehensive transcriptomic data about molecular responses in C. viniferum-infected grape, and these data will aid in understanding of processes underlying plant responses to C. viniferum.
The Inheritance Pattern of Key Desirable Agronomic and Fruit Quality Traits in Elite Red Papaya Genotypes
Authors: Ali Fawad , Kanchana-udomkan Chutchamas , Ford Rebecca
Published: September 2022

Knowledge of the heritability, genetic advance, and stability of key traits, such as the height to the first fruit, trunk circumference, number of marketable fruit, wasted fruit, fruit weight, fruit width, fruit length, flesh thickness, cavity width, cavity length, and soluble solid contents, is required. These were determined in ten advanced generation red papaya recombinant inbred lines (RIL; F5 generation). The F5 RIL were grown in four field sites, two each within two distinct agroecological climates: the Tablelands and Coastal regions. At each site, biological replicates (trees) of each RIL and the industry-standard red papaya cultivar, RB1, were grown. Agronomic traits and fruit-specific traits were assessed at five and 10 months, respectively, after seedling transplantation to the field. Height to first fruit, trunk circumference, fruit weight, and soluble solid contents were highly heritable and stable at all field sites (h2b.s, 0.7–0.9) with genetic gains of almost 18% observed for height to first fruit and fruit weight. Across all sites, the trunks of the F5 lines were 37% wider, the trees set fruit 47% closer to the ground and had 20% more marketable fruit with 33% smaller fruit cavity widths, and their fruit was 11% heavier and 12% sweeter than RB1.
Singapore’s Forgotten Stories: The Orang Kallang Tribe of Kallang River
Authors: Ong Brenda Man Qing , Perono Cacciafoco Francesco
Published: September 2022

This article studies and provides a narrative review of the history of the native Orang Kallang people residing on Singapore’s Kallang River before Singapore’s modernization. The first section delves into the Orang Laut and how a group of them moved to the Kallang River to form the independent tribe of the Orang Kallang. This is followed by the historical significance of the Kallang River and its role in trade and maritime commerce in early Singapore. Subsequently, the second section investigates the Orang Kallang’s origins, livelihood, language, and reasons for their eventual decline. As the Orang Kallang tribe split after the arrival of the British in 1819, the group that settled in Pulai River, Johor, was recorded to have dwindled staggeringly in population due to a smallpox epidemic. The third section will focus on the impact of smallpox on the early aboriginal populations of Singapore (and the overarching region of Malaya), failed vaccination attempts, and how the Orang Kallang was likely to have been impacted. The last section will sum up the themes discussed in the paper.
Hydrobiological Aspects of Fatty Acids: Unique, Rare, and Unusual Fatty Acids Incorporated into Linear and Cyclic Lipopeptides and Their Biological Activity
Authors: Dembitsky Valery M.
Published: September 2022

The study of lipopeptides and their related compounds produced by various living organisms from bacteria to marine invertebrates is of fundamental interest for medicinal chemistry, pharmacology, and practical clinical medicine. Using the principles of retrosynthetic analysis of linear and cyclic peptides, the pharmacological activity of unique, unusual, and rare fatty acids (FA) that are part of natural lipopeptides was investigated. To search for new biologically active natural metabolites from natural sources, more than 350 FA incorporated into linear and cyclic peptides isolated from bacteria, cyanobacteria, microalgae, marine invertebrates, fungal endophytes, and microorganisms isolated from sediments are presented. Biological activities have been studied experimentally in various laboratories, as well as data obtained using QSAR (Quantitative Structure-Activity Relationships) algorithms. According to the data obtained, several FA were identified that demonstrated strong antibacterial, antimicrobial, antifungal, or antitumor activity. Along with this, FA have been found that have shown rare properties such as antiviral, antidiabetic, anti-helmintic, anti-inflammatory, anti-psoriatic, anti-ischemic, and anti-infective activities. In addition, FA have been found as potential regulators of lipid metabolism, as well as agents for the treatment of acute neurological disorders, as well as in the treatment of atherosclerosis and multiple sclerosis. For 36 FA, 3D graphs are presented, which demonstrate their predicted and calculated activities.
Interventions by Caregivers to Promote Motor Development in Young Children, the Caregivers’ Attitudes and Benefits Hereof: A Scoping Review
Authors: Pedersen Marlene Rosager Lund , Hansen Anne Faber
Published: September 2022

In the first year of life, the child’s caregivers, including parents and daycare staff, play an essential role, as they are responsible for implementing daily activities to promote the motor development of young children. However, what does the research show about interventions to promote the motor development of 0–36-month-olds carried out by the child’s caregivers, and what are the caregivers’ experiences and attitudes hereof? This scoping review aims to provide an overview of the published studies to derive an overall interpretation. A systematic search was conducted in five scientific databases, resulting in 10,219 articles, of which 9 met the inclusion criteria. The results indicate that providing early intervention to 0–36-month-old children, in which the caregivers carry out the activities, promotes the young child’s motor development. Furthermore, the interventions increase the caregivers’ interest and motivation to promote the young child’s motor development, which is essential in maintaining the behaviour after the end of the interventions. Supervision and guidance provided for the child’s caregivers concerning knowledge and skills about age-appropriate behaviours and facilitation of their child’s motor development increases the caregivers’ self-confidence, interest, and motivation.
Analysis of Air and Soil Quality around Thermal Power Plants and Coal Mines of Singrauli Region, India
Authors: Romana Harsimranjit Kaur , Singh Ramesh P. , Dubey Chandra S. , Shukla Dericks P.
Published: September 2022

Singrauli region is known as the energy capital of India, as it generates nearly 21 GW of electricity, supplied to various parts of the northern India. Many coal-based Thermal Power Plants (TPPs) using coal from several nearby coal mines, and numerous industries are set up in this region which has made it as one of the highly polluted regions of India. In the present study, detailed temporal analysis and forecast of carbon dioxide (CO2), nitrogen dioxide (NO2), sulfur dioxide (SO2), and methane (CH4) concentrations retrieved from satellite data have been carried out for the periods 2005–2020. Based on the classical multiplicative model and using linear regression, the maximum concentration of CO2, NO2, SO2, and CH4 in the year 2025 is found to be 422.59 ppm, 29.28 ppm, 0.23 DU, and 1901.35 ppbv, respectively. Detailed analysis shows that carbon dioxide has a 95% correlation with all other trace gases. We have also carried out the geo-accumulation index for the presence of various contaminants in the soil of this region. The geo-accumulation index shows that soil in and around thermal power plants and coal mines is contaminated by heavy metals. The cumulative index shows that soil around Hindalco industries, Bina coal mines, Khadia coal mines, and coal-based TPPs (Anpara and Vindhayachal) are highly polluted and a threat to human population living in the region.
Adverse Childhood Experiences and Education Outcomes among Adolescents: Linking Survey and Administrative Data
Authors: Stewart-Tufescu Ashley , Struck Shannon , Taillieu Tamara , Salmon Samantha , Fortier Janique , Brownell Marni , Chartier Mariette , Yakubovich Alexa R. , Afifi Tracie O.
Published: September 2022

It is well established that adverse childhood experiences (ACEs) are associated with detrimental health outcomes in adulthood. Less is known about the relationships between ACEs and education outcomes and among adolescents. The aim of this study was to examine the associations between ACEs and adolescents’ self-reported education outcomes and provincial education assessments among adolescents in Manitoba, Canada. Data were gathered from 1002 adolescents who participated in the Well-Being and Experiences (WE) Study. A subsample of the adolescents (84%) consented to having their WE survey data linked to administrative education databases. Binary and multinomial logistic regression models were computed to examine associations between ACE history and self-reported education outcomes and provincial education assessments, adjusting for sociodemographic variables. Adolescents with an ACE history had significantly increased likelihood of having ever been suspended from school (adjusted odds ratio (aOR) = 3.33, 95% CI 1.60–6.92), of lower grades (adjusted relative risk ratio (aRRR) = 3.21, 95% CI 1.42–7.29), and of chronic school absenteeism (aRRR = 2.45, 95% CI 1.28–4.68) compared with adolescents without an ACE history after adjusting for sociodemographic variables. Findings from this study illuminate the important relationship between childhood adversity and poor education outcomes assessed directly by adolescents. Increasing awareness of the public health risk associated with ACEs and education outcomes may inform education policy and school-based interventions.
Household Wealth and Individuals’ Mental Health: Evidence from the 2012–2018 China Family Panel Survey
Authors: Zhang Rui , Zhang Chenglei , Xia Jiahui , Feng Dawei , Wu Shaoyong
Published: September 2022

Based on the data from the 2012–2018 China Family Panel Survey, this study examines the impact of household wealth on individuals’ mental health using a two-way fixed effects model. The findings indicate that household wealth exerts a significant positive effect on individuals’ mental health. Furthermore, this study shows that the impact of household wealth on individuals’ mental health is nonlinear but inverted U-shaped. Considering the possible endogeneity problem, this study further examines the effect of household wealth on residents’ mental health using two-stage least squares, and the conclusions remain robust. The results of the heterogeneity analysis indicate that household wealth has a greater impact on the mental health of residents in the low-education group and western region. Furthermore, the results of the mechanisms reveal that household wealth affects mental health by influencing insurance investment and individuals’ labor supply. Moreover, this study finds that household wealth affects individuals’ mental health not only in the short term but also in the medium and long terms. This study provides policy implications for the government toward improving individuals’ mental health.
An International Systematic Review of Prevalence, Risk, and Protective Factors Associated with Young People’s E-Cigarette Use
Authors: Kim Jinyung , Lee Serim , Chun JongSerl
Published: September 2022

While the prevalence of young people’s conventional cigarette use has decreased in many countries, the use of e-cigarettes has risen. To effectively counteract the growing popularity of e-cigarettes among young people internationally, researchers should know the exact prevalence as well as the protective and risk factors associated with vaping. Based on five eligibility criteria, 53 articles were chosen and analyzed by general characteristics, prevalence, sample characteristics, gender difference, protective factors, and risk factors. In this study, the international pooled prevalence of young people’s lifetime e-cigarette use was 15.3%, the current use was 7.7%, and dual use was 4.0%. While the highest lifetime, current, and dual prevalence were found in Sweden, Canada, and the United Kingdom, respectively, the lowest prevalence was found in Germany, followed by South Korea and Sweden. Some protective and risk factors include perceived cost and danger of vaping, parental monitoring, internal developmental assets, cigarette use, family and peer smoking, exposure to online advertisements, and the presence of nearby retail stores. Based on this review, researchers and practitioners can develop different intervention programs and strategies for young smokers.
Pan-Genome-Assisted Computational Design of a Multi-Epitopes-Based Vaccine Candidate against Helicobacter cinaedi
Authors: Ismail Saba , Alsowayeh Noorah , Abbasi Hyder Wajid , Albutti Aqel , Tahir ul Qamar Muhammad , Ahmad Sajjad , Raza Rabail Zehra , Sadia Khulah , Abbasi Sumra Wajid
Published: September 2022

Helicobacter cinaedi is a Gram-negative bacterium from the family Helicobacteraceae and genus Helicobacter. The pathogen is a causative agent of gastroenteritis, cellulitis, and bacteremia. The increasing antibiotic resistance pattern of the pathogen prompts the efforts to develop a vaccine to prevent dissemination of the bacteria and stop the spread of antibiotic resistance (AR) determinants. Herein, a pan-genome analysis of the pathogen strains was performed to shed light on its core genome and its exploration for potential vaccine targets. In total, four vaccine candidates (TonB dependent receptor, flagellar hook protein FlgE, Hcp family type VI secretion system effector, flagellar motor protein MotB) were identified as promising vaccine candidates and subsequently subjected to an epitopes’ mapping phase. These vaccine candidates are part of the pathogen core genome: they are essential, localized at the pathogen surface, and are antigenic. Immunoinformatics was further applied on the selected vaccine proteins to predict potential antigenic, non-allergic, non-toxic, virulent, and DRB*0101 epitopes. The selected epitopes were then fused using linkers to structure a multi-epitopes’ vaccine construct. Molecular docking simulations were conducted to determine a designed vaccine binding stability with TLR5 innate immune receptor. Further, binding free energy by MMGB/PBSA and WaterSwap was employed to examine atomic level interaction energies. The designed vaccine also stimulated strong humoral and cellular immune responses as well as interferon and cytokines’ production. In a nutshell, the designed vaccine is promising in terms of immune responses’ stimulation and could be an ideal candidate for experimental analysis due to favorable physicochemical properties.
Long-Term Effects of Ambient Particulate and Gaseous Pollutants on Serum High-Sensitivity C-Reactive Protein Levels: A Cross-Sectional Study Using KoGES-HEXA Data
Authors: Kim Ji Hyun , Woo Hae Dong , Choi Sunho , Song Dae Sub , Lee Jung Hyun , Lee Kyoungho
Published: September 2022

Ambient air pollutants reportedly increase inflammatory responses associated with multiple chronic diseases. We investigated the effects of long-term exposure to ambient air pollution on high-sensitivity C-reactive protein (hs-CRP) using data from 60,581 participants enrolled in the Korean Genome and Epidemiology Study-Health Examinees Study between 2012 and 2017. Community Multiscale Air Quality System with surface data assimilation was used to estimate the participants’ exposure to criteria air pollutants based on geocoded residential addresses. Long-term exposure was defined as the 2-year moving average concentrations of PM10, PM2.5, SO2, NO2, and O3. Multivariable linear and logistic regression models were utilized to estimate the percent changes in hs-CRP and odds ratios of systemic low-grade inflammation (hs-CRP > 3 mg/L) per interquartile range increment in air pollutants. We identified positive associations between hs-CRP and PM10 (% changes: 3.75 [95% CI 2.68, 4.82]), PM2.5 (3.68, [2.57, 4.81]), SO2 (1.79, [1.10, 2.48]), and NO2 (3.31, [2.12, 4.52]), while negative association was demonstrated for O3 (−3.81, [−4.96, −2.65]). Elevated risks of low-grade inflammation were associated with PM10 (odds ratio: 1.07 [95% CI 1.01, 1.13]), PM2.5 (1.08 [1.02, 1.14]), and SO2 (1.05 [1.01, 1.08]). The odds ratios reported indicated that the exposures might be risk factors for inflammatory conditions; however, they did not reflect strong associations. Our findings suggest that exposure to air pollutants may play a role in the inflammation process.
The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid among Patients with Endometriosis and Endometriosis-Related Infertility
Authors: Goławski Ksawery , Soczewica Robert , Kacperczyk-Bartnik Joanna , Mańka Grzegorz , Kiecka Mariusz , Lipa Michał , Warzecha Damian , Spaczyński Robert , Piekarski Piotr , Banaszewska Beata , Jakimiuk Artur , Issat Tadeusz , Rokita Wojciech , Młodawski Jakub , Szubert Maria , Sieroszewski Piotr , Raba Grzegorz , Szczupak Kamil , Kluz Tomasz , Kluza Marek , Wielgoś Mirosław , Koc-Żórawska Ewa , Żórawski Marcin , Laudański Piotr
Published: September 2022

Cadherin 12 (CDH 12) can play a role in the pathogenesis of endometriosis. The aim of this study was to compare the levels of cadherin 12 in the peritoneal fluid between women with and without endometriosis. This was a multicenter cross-sectional study. Eighty-two patients undergoing laparoscopic procedures were enrolled in the study. Cadherin 12 concentrations were determined using the enzyme-linked immunosorbent assay. The level of statistical significance was set at p < 0.05. No differences in cadherin 12 concentrations between patients with and without endometriosis were observed (p = 0.4). Subgroup analyses showed that CDH 12 concentrations were significantly higher in patients with infertility or primary infertility and endometriosis in comparison with patients without endometriosis and without infertility or primary infertility (p = 0.02) and also higher in patients with stage I or II endometriosis and infertility or primary infertility than in patients without endometriosis and infertility or primary infertility (p = 0.03, p = 0.048, respectively). In total, CDH 12 levels were significantly higher in patients diagnosed with infertility or primary infertility (p = 0.0092, p = 0.009, respectively) than in fertile women. Cadherin 12 can possibly play a role in the pathogenesis of infertility, both in women with and without endometriosis.
Adaptation and Preliminary Validation of the Fear of Coronavirus Vaccination Scale in the Prospective Study among a Representative Sample of Polish, Israeli, Slovenian, and German Adults during the COVID-19 Pandemic
Authors: Ochnik Dominika , Rogowska Aleksandra , Benatov Joy , Arzenšek Ana
Published: September 2022

Although concerns about harm and side effects are among the most important factors determining vaccine hesitancy, research on the fear of vaccination is sparse. The purpose of this study is a validation the Fear of Coronavirus Vaccination Scale (FoCVVS), adapted from the Fear of COVID-19 Scale. A representative sample of 1723 young adults aged 20–40 from Poland, Israel, Slovenia, and Germany participated during two time-points of the third COVID-19 pandemic wave. The online survey included demographic variables and several well-being dimensions, including gender, vaccination status, fear of coronavirus (FoCV-19S), physical health (GSRH), life satisfaction (SWLS), and perceived stress (PSS-10), anxiety (GAD-7), and depression (PHQ-9). Exploratory factor analysis (EFA) was performed at T1, and confirmatory analysis (CFA) at T2. The second-order two-factor structure demonstrated the best fit and very good discriminant and convergent validation. The general factor of the FoCVVS included two subscales assessing the emotional and physiological symptoms of fear of vaccination. Unvaccinated people showed higher levels of fear of vaccination than those vaccinated. A vaccination status, fear of vaccination T1, and fear of COVID-19 T1 were significant predictors of fear of vaccination T2. Vaccination-promoting programs should be focused on decreasing fear and enhancing the beneficial effects of vaccination.
Correlates of Caregiving Burden among Bedouin-Muslim Mothers of Children Diagnosed with Epilepsy
Authors: Edelstein Offer E. , Shorer Talia , Shorer Zamir , Bachner Yaacov G.
Published: September 2022

A paucity of research exists on caregiving burden (CB) and the factors associated with it among minority groups, such as Bedouin mothers of children diagnosed with epilepsy (CDE). The aim of this study was to explore associations between CB and care-recipients’ characteristics, contextual factors, and caregivers’ characteristics among those mothers. Methods: A total of 50 mothers completed self-report questionnaires while visiting pediatric neurology outpatient clinic centers, using valid and reliable measures. Results: Bivariate associations were found between social support, number of medications, and CB. General self-efficacy and place of residence emerged as significant predictors of caregiver burden. Conclusions: These findings provide health professionals with a better understanding of the factors that should be assessed in order to address caregiver burden among Bedouin mothers of CDE. Understanding the unique characteristics and culture of the Bedouin community can help professionals in targeting caregivers with a lower sense of self-efficacy, and those that reside in Bedouin cities, in order to reduce their caregiving burden.
The Relationship among College Students’ Physical Exercise, Self-Efficacy, Emotional Intelligence, and Subjective Well-Being
Authors: Wang Kun , Li Yan , Zhang Tingran , Luo Jiong
Published: September 2022

Purpose: To deeply analyze the influencing factors on college students’ subjective well-being and the path mechanism between each factor. Method: The physical activity rating scale (PARS-3), the emotional intelligence scale (EIS), the self-efficacy scale (GSES), and the subjective well-being scale (SWS) were used for 826 students from two comprehensive universities in southwest China. College students conducted a questionnaire survey, and used SPSS22.0 and AMOS21.0 statistical software to process and analyze the obtained data. Results: (1) Physical exercise was significantly positively correlated with self-efficacy, emotional intelligence, and subjective well-being; self-efficacy was significantly positively correlated with emotional intelligence and subjective well-being; emotional intelligence was significantly positively correlated with subjective well-being; (2) Physical exercise has a direct positive predictive effect on subjective well-being (ES = 0.16); (3) Self-efficacy (ES = 0.057) and emotional intelligence (ES = 0.077) play a part in mediating the role between physical exercise and subjective well-being, respectively. Meanwhile, the chain mediation effect (ES = 0.026) of self-efficacy and emotional intelligence also achieved a significant level, among them, only others’ emotional management and emotional application were involved in the regulation of emotional intelligence. Conclusions: Actively participating in physical exercise could not only directly improve the level of subjective well-being of college students but also indirectly affect their subjective well-being by improving their self-efficacy, as well as their emotional management and emotional application abilities, thereby improving college students’ life satisfaction feelings of happiness, such as degree, positive emotion, and negative emotion.
Exploring Spatial Features of Population Activities and Functional Facilities in Rail Transit Station Realm Based on Real-Time Positioning Data: A Case of Xi’an Metro Line 2
Authors: Wang Di , Dewancker Bart , Duan Yaqiong , Zhao Meng
Published: September 2022

The rail transit station realm is an important urban spatial node that carries various behavioral activities and multiple functions. In order to accurately identify the spatial and temporal distribution of population activities and functional facilities in the rail transit station realm and understand the dynamic influence relationship between them, this paper takes four different types of stations of Xi’an Metro Line 2 as the research object, using real-time positioning data to represent population activities and points of interest (POIs) to represent functional facilities. An analytical framework combining the spatial point pattern identification technique and ordinary least squares (OLS) regression model is proposed. The results show that (1) there is spatial and temporal heterogeneity in the population activities in the rail transit station realm; the density distribution of population activities in different time periods shows the characteristic of clustering within 500 m of the station, regardless of working days or off days; (2) the distribution of shopping service POI, catering service POI, and living service POI in different station realms shows the feature of clustering around the stations; (3) the catering POI, living POI, shopping POI and transportation POI have positive attraction to population activities in different time periods; the constructed OLS model can basically explain the influence relationship between various functional facilities and population activities in all time periods. The conclusions can help city managers understand the spatial and temporal distribution and intrinsic mechanisms of population activities and functional facilities from a microscopic perspective and provide an effective decision-making basis for optimizing the allocation of functional resources in the station realm.
Exploring the Inter-Monthly Dynamic Patterns of Chinese Urban Spatial Interaction Networks Based on Baidu Migration Data
Authors: Jiang Heping , Luo Shijia , Qin Jiahui , Liu Ruihua , Yi Disheng , Liu Yusi , Zhang Jing
Published: September 2022

The rapid development of the economy promotes the increasing of interactions between cities and forms complex networks. Many scholars have explored the structural characteristics of urban spatial interaction networks in China and have conducted spatio-temporal analyzes. However, scholars have mainly focused on the perspective of static networks and have not understood the dynamic spatial interaction patterns of Chinese cities. Therefore, this paper proposes a research framework to explore the urban dynamic spatial interaction patterns. Firstly, we establish a dynamic urban spatial interaction network according to monthly migration data. Then, the dynamic community detection algorithm, combined with the Louvain and Jaccard matching method, is used to obtain urban communities and their dynamic events. We construct event vectors for each urban community and use hierarchical clustering to cluster event vectors to obtain different types of spatial interaction patterns. Finally, we divide the urban dynamic interaction into three urban spatial interaction modes: fixed spatial interaction pattern, long-term spatial interaction pattern, and short-term spatial interaction pattern. According to the results, we find that the cities in well-developed areas (eastern China) and under-developed areas (northwestern China) mostly show fixed spatial interaction patterns and long-term spatial interaction patterns, while the cities in moderately developed areas (central and western China) often show short-term spatial interaction patterns. The research results and conclusions of this paper reveal the inter-monthly urban spatial interaction patterns in China, provide theoretical support for the policy making and development planning of urban agglomeration construction, and contribute to the coordinated development of national and regional cities.
Transcriptome Analysis of Beet Webworm Shows That Histone Deacetylase May Affect Diapause by Regulating Juvenile Hormone
Authors: Cui Jin , Lin Kejian , Xu Linbo , Yue Fangzheng , Yu Liangbin , Zhang Quanyi
Published: September 2022

The beet webworm (Loxostege sticticalis L.) is an important agricultural pest and can tolerate harsh environmental conditions by entering diapause. The diapause mechanism of beet webworm is unknown. Therefore, we conducted a transcriptomic study of the process from diapause induction to diapause release in beet webworms. The results revealed 393 gene modules closely related to the diapause of beet webworm. The hub gene of the red module was the HDACI gene, which acts through histone deacetylase (HDAC) enzymes. HDAC enzyme activity was regulated by the light duration and influenced the JH content under induced beet webworm diapause conditions (12 h light:12 h dark). In addition, transcriptomic data suggested that circadian genes may not be the key genes responsible for beet webworm diapause. However, we showed that the photoperiod affects HDAC enzyme activity, and HDAC can regulate the involvement of JH in beet webworm diapause. This study provided a new module for studying insect diapause and links histone acetylation and diapause at the transcriptome level.
The Effect of Feeding with Central European Local Mulberry Genotypes on the Development and Health Status of Silkworms and Quality Parameters of Raw Silk
Authors: Urbanek Krajnc Andreja , Bakonyi Tamas , Ando Istvan , Kurucz Eva , Solymosi Norbert , Pongrac Paula , Berčič Rebeka Lucijana
Published: September 2022

Silkworm rearing activities ceased in the 1970′s in several European countries. Attempts on the re-establishment of ecological and sustainable sericulture in Slovenia and Hungary are ongoing. The aim of the study was to assess the usability of locally adapted mulberry genotypes for sericulture and to estimate connections between leaf compound and silkworm performance parameters. A controlled feeding experiment of silkworms was performed to test the influence of leaves from selected trees on the growth of larvae, the health and microbiological status of larvae (e.g., gut bacterial microbiome, Bombyx mori nucleopolyhedrovirus infection), weight of cocoons and raw silk parameters. The Slovenian and Hungarian mulberry genotypes had significantly higher total protein contents, and lower total phenolic contents and differed significantly in some individual phenolics compared to the reference sericultural and fruit varieties. Significant differences were found in the contents of the macro- and microelements, namely S, Mn, Fe, and Sr. Based on correlative statistics and multivariate analysis, a combined positive influence of proteins, specific phenolics, and microelements on larval growth and silk thread parameters was predicted. The results of the study indicate that selected local Slovenian and Hungarian mulberry varieties are suitable for high-quality silk cocoon and raw silk production.