bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing biological control of postharvest green mold in lemons: Synergistic efficacy of native yeasts with diverse mechanisms of action
Authors: Pereyra Martina María , Díaz Mariana Andrea , Vero Silvana , Dib Julián Rafael
Published: April 2024

Argentina is among the most important lemon fruit producers in the world. Penicillium digitatum is the primary lemon fungal phytopathogen, causing green mold during the postharvest. Several alternatives to the use of synthetic fungicides have been developed, being the use of biocontrol yeasts one of the most promising. Although many of the reports are based on the use of a single yeast species, it has been shown that the combination of agents with different mechanisms of action can increase control efficiency through synergistic effects. The combined use of native yeasts with different mechanisms of action had not been studied as a biological control strategy in lemons. In this work, the mechanisms of action of native yeasts (Clavispora lusitaniae AgL21, Clavispora lusitaniae AgL2 and Clavispora lusitaniae AcL2) with biocontrol activity against P. digitatum were evaluated. Isolate AgL21 was selected for its ability to form biofilm, colonize lemon wounds, and inhibit fungal spore germination. The compatibility of C. lusitaniae AgL21 with two killer yeasts of the species Kazachstania exigua (AcL4 and AcL8) was evaluated. In vivo assays were then carried out with the yeasts applied individually or mixed in equal cell concentrations. AgL21 alone was able to control green mold with 87.5% efficiency, while individual killer yeasts were significantly less efficient (43.3% and 38.3%, respectively). Inhibitory effects were increased when C. lusitaniae AgL21 and K. exigua strains were jointly applied. The most efficient treatment was the combination of AgL21 and AcL4, reaching 100% efficiency in wound protection. The combination of AgL21 with AcL8 was as well promising, with an efficiency of 97.5%. The combined application of native yeasts showed a synergistic effect considering that the multiple mechanisms of action involved could hinder the development of green mold in lemon more efficiently than using single yeasts. Therefore, this work demonstrates that the integration of native yeasts with diverse modes of action can provide new insights to formulate effective microbial consortia. This could lead to the development of tailor-made biofungicides, allowing control of postharvest fungal diseases in lemons while remaining competitive with traditionally used synthetic chemicals.
Mindfulness Teacher Trainees’ Experiences (MTTE): An investigation of intense experiences in mindfulness-based interventions
Authors: Jönhagen Erik , Wood Tim , Niemi Maria , Galante Julieta
Published: April 2024

With the increasing interest in mindfulness practices within clinical as well as non-clinical settings and the increasing body of research on the positive effects of mindfulness, concerns have been raised that mindfulness might also produce adverse effects including intense experiences and psychosis. The aim of this study was to investigate if intense experiences occur as a natural part of mindfulness practice, and if so to examine the characteristics of such experiences. We conducted a qualitative analysis based on fortnightly meditation reports from 13 mindfulness teacher trainees for 4 months. Intense experiences in meditation were frequently expressed in the reports of most of the practitioners and in some individuals these experiences were similar to psychotic-like experiences. This study presents suggestive evidence that mindfulness practices can produce intense experiences and that for some individuals these intense experiences may resemble psychotic-like experiences.
Burden of undernutrition among under-five Bengali children and its determinants: Findings from Demographic and Health Surveys of Bangladesh and India
Authors: Kundu Ramendra Nath , Hossain Md. Golam , Haque Md. Ahshanul , Mahumud Rashidul Alam , Pal Manoranjan , Bharati Premananda
Published: April 2024

Background

Globally, undernutrition is the leading cause of mortality among under-five children. Bangladesh and India were in the top ten countries in the world for under-five mortality. The aim of the study was to investigate the nutritional status of Bengali under-five children.

Methods

Data on 25938 under-five children were retrieved from the Bangladesh Demographic and Health Survey 2017–18 (BDHS) and the National Family Health Survey of India 2015–16 (NFHS-4). Stunting, wasting, underweight and thinness were considered to understand the nutritional status of under-five children. Binary logistic regression was used to identify associated factors of undernutrition among children.

Results

Over one-quarter of Bengali under-five children were found to be suffering from the problem of stunting (31.9%) and underweight (28.1%), while other nutritional indicators raised serious concern and revealed inter-country disparities. In the cases of wasting, underweight and thinness, the mean z-scores and frequency differences between Bangladesh and India were significant. The nutritional status of Bengali under-five children appeared to have improved in Bangladesh compared to India. Child undernutrition had significant relations with maternal undernutrition in both countries. Girls in Bangladesh had slightly better nutritional status than boys. In Bangladesh, lack of formal education among mothers was a leading cause of child undernutrition. Stunting and underweight coexist with low household wealth index in both counties.

Conclusions

The research revealed that various factors were associated with child undernutrition in Bengalis. It has been proposed that programmes promoting maternal education and nutrition, along with household wealth index be prioritised. The study recommends that the Governments of Bangladesh and India should increase the budget for health of children so as to reach the sustainable development goals.
Dynamic changes of Bacterial Microbiomes in Oropharynx during Infection and Recovery of COVID-19 Omicron Variant
Authors: Cui Guangying , Sun Ying , Zou Yawen , Sun Ranran , Gao Yanxia , Liu Xiaorui , Zhou Yongjian , Zhang Donghua , Wang Xueqing , Li Yonghong , Liu Liwen , Zhang Guizhen , Rao Benchen , Yu Zujiang , Ren Zhigang
Published: April 2024

Oropharyngeal microbiomes play a significant role in the susceptibility and severity of COVID-19, yet the role of these microbiomes play for the development of COVID-19 Omicron variant have not been reported. A total of 791 pharyngeal swab samples were prospectively included in this study, including 297 confirmed cases of Omicron variant (CCO), 222 confirmed case of Omicron who recovered (CCOR), 73 confirmed cases of original strain (CCOS) and 199 healthy controls (HC). All samples completed MiSeq sequencing. The results showed that compared with HC, conditional pathogens increased in CCO, while acid-producing bacteria decreased. Based on six optimal oropharyngeal operational taxonomy units (OTUs), we constructed a marker microbial classifier to distinguish between patients with Omicron variant and healthy people, and achieved high diagnostic efficiency in both the discovery queue and the verification queue. At same time, we introduced a group of cross-age infection verification cohort and Omicron variant subtype XBB.1.5 branch, which can be accurately distinguished by this diagnostic model. We also analyzed the characteristics of oropharyngeal microbiomes in two subgroups of Omicron disease group—severity of infection and vaccination times, and found that the change of oropharyngeal microbiomes may affect the severity of the disease and the efficacy of the vaccine. In addition, we found that some genera with significant differences gradually increased or decreased with the recovery of Omicron variant infection. The results of Spearman analysis showed that 27 oropharyngeal OTUs were closely related to 6 clinical indexes in CCO and HC. Finally, we found that the Omicron variant had different characterization of oropharyngeal microbiomes from the original strain. Our research characterizes oropharyngeal microbiomes of Omicron variant cases and rehabilitation cases, successfully constructed and verified the non-invasive diagnostic model of Omicron variant, described the correlation between microbial OTUs and clinical indexes. It was found that the infection of Omicron variant and the infection of original strain have different characteristics of oropharyngeal microbiomes.
Writing sound in the screenplay: Traditions and innovations
Authors: Paletz Gabriel M.
Published: April 2024

Despite the rich literature on both film sound and screenwriting, there is a paucity of practical advice in current Hollywood screenwriting guides on how to write sound into scripts. This essay encourages the work of screenwriters, screenwriting teachers, students and cinema scholars in two ways. It both reviews the traditions for integrating sound into screenplays and introduces innovations in the classical script format for writing sound. A sequence of off-screen sounds can convey a whole series of actions, while sounds in an outline or synopsis can structure an entire film narrative. As in past screenplays, sounds can again be written side by side in tandem with yet independently from images. Finally, the article makes original emendations to the classical master scene format for writing dominant sounds that fill a scene as well as indications for movie music. At a time when both film production and the screenplay itself are being transformed, this essay rejuvenates both film scholarship and practice by bridging historical traditions with practical innovations for screenwriting sound.
Developmental relationship between junctional epithelium and epithelial rests of Malassez
Authors: Li Shubo , Li Shufang , Cao Mingguo
Published: April 2024

Keratin 17 (K17) is thought to be a candidate target gene for regulation by Lymphoid Enhancer Factor-1 (Lef-1). K17 is a marker that distinguishes junctional epithelium (JE) from epithelial rests of Malassez (ERM). However, the relationship of Lef-1 to K17 is not clear in this context. Moreover, the expression of other keratins such as K5, K6, K7 and K16 is not reported. Therefore, the aim of our study was to assay the expression of K5, K6, K7, K14, K16, K17 and Lef-1 in postnatal developing teeth, and clarify the corresponding immunophenotypes of the JE and ERM. Upper jaws of Wistar rats aged from postnatal (PN) day 3.5 to PN21 were used and processed for immunohistochemistry. K5 and K14 were intensely expressed in inner enamel epithelium (IEE), reduced enamel epithelium (REE), ERM and JE. There was no staining for K16 in the tissue, except for strong staining in the oral epithelium. Specifically, at PN3.5 and PN7, K17 was initially strongly expressed and then negative in the IEE. At PN16 and PN21, both REE and ERM were strongly stained for K17, whereas K17 was negative in the JE. In addition, K6, K7 and Lef-1 were not detected in any tissue investigated. REE and ERM have an identical keratin expression pattern before eruption, while JE differs from ERM in the expression of K17 after eruption. The expression of K17 does not coincide with that of Lef-1. These data indicate that JE has a unique phenotype different from ERM, which is of odontogenic origin.
Artistic Representation of Gender Nonconforming Female Bodies in Social Media: A Study of Select Indian Graphic Artists on Instagram
Authors: Bose Aratrika , Tanupriya  , Singh Anuja
Published: April 2024

The study critically examines gender nonconforming female identities via their sexualized representations through artistic imagination on Instagram. Instagram representation becomes a ‘political act’ where this visual subversion allows the queer to reclaim their non-binary identity and thus articulate their choices through their body. The digital graphic art taken under study is select images from the Instagram pages of Indian artists “artwhoring,” “aorists,” and “sayartic.” The research study examines the question of an ideal hegemonic femininity perpetuated by the rhetoric of Indian heteronormative patriarchal assertions. It analyses select images that defy hegemonic femininity and gender binary by embodying an amalgamation of masculinity and femininity and lesbian desire which forms an act of subversion. The methodology of critical discourse analysis is employed to study Instagram art and the critical frameworks of the fantasy female body, and the notion of heteropatriarchal femininity. In conclusion, the study discusses the treatment of female gender non-conforming bodies, their appearance, lesbian desire, and body image. Such transgressive depiction of bodies successfully situates the female body beyond the dichotomy of masculinity and femininity.
Tax Compliance Actions by Tax Authorities and Voluntary Compliance with Tax Obligations by Individual Taxpayers
Authors: Bezerra Thales Vinícius Santiago , Oliveira Oderlene Vieira de , Souza Lucas Lopes Ferreira de
Published: April 2024

Research objective: Tax compliance actions aim to improve the relationship between the tax authorities and taxpayers, increasing voluntary compliance with tax obligations and reducing administrative and judicial litigation. In this sense, the defined objective was to analyze whether tax compliance actions increase voluntary compliance with tax obligations.
Methodology: Thus, a quantitative approach was used, through analysis of latent classes, carried out on the baseed on longitudinal data from the Federal Revenue, with 531 individual taxpayers, related to compliance action.
Results: After the action, it was found that the taxes owed had a statistically significant increase and the tax gap was increasingly reduced between 2015 and 2018, indicating that the implemented tax compliance actions were effective in promoting voluntary compliance with tax obligations by taxpayers. In addition, the action also presented advantages to taxpayers, since, when there is a spontaneous regularization, there is less possibility of facing a tax procedure, as well as a reduction in administrative costs and  the amount of litigation.
Practical and theoretical contributions: The practical contributions are aimed at enhancing future tax compliance initiatives carried out by Federated Entities. Furthermore, the theoretical contribution utilizes the Slippery Slope Model, which illustrates an upsurge in voluntary compliance with tax obligations following a compliance action, attributed to heightened authority and confidence in the tax regulatory body. As a result, this theoretical contribution underscores the significance of the Slippery Slope Model in comprehending taxpayer behavior and in devising more efficient tax compliance strategies.
Securing Artificial Intelligence Models: A Comprehensive Cybersecurity Approach
Authors: Olugboja Adedeji
Published: April 2024

As artificial intelligence (AI) becomes integral to diverse applications, the imperative to secure AI models against evolving threats has gained paramount importance. This paper presents a novel cybersecurity framework tailored explicitly for AI models, synthesizing insights from a comprehensive literature review, real-world case studies, and practical implementation strategies. Drawing from seminal works on adversarial attacks, data privacy, and secure deployment practices, the framework addresses vulnerabilities throughout the AI development lifecycle. Preliminary results indicate a significant enhancement in the resilience of AI models, demonstrating reduced success rates of adversarial attacks, effective data encryption, and robust secure deployment practices. The framework's adaptability across diverse use cases underscores its practicality. These findings mark a crucial step toward establishing comprehensive and practical cybersecurity measures, contributing to the ongoing discourse on securing the expanding field of artificial intelligence. Ongoing efforts involve further validation, optimization, and exploration of additional security measures to fortify AI models in an ever-changing threat landscape.
An Examination of the Characteristics and Interests of Undergraduate Students in Entrepreneurship
Authors: Mohd Pauzi Nur Farahah , Mustafa Mohd Ariff , Shamsudin Adriana , Ahmad Khairiah , Zazali Ainol Sarina Ahmad , Jailani Jalaluddin Mohamad
Published: April 2024

The Malaysian government has developed many programmes to encourage entrepreneurial activities among university graduates, aiming to provide them with the necessary information, skills, and mindset to start successful and enduring firms. Despite these efforts, the rate of graduates involved in entrepreneurship remains low. With the rising unemployment rate in the country, worsened by the difficult economic conditions following the COVID-19 pandemic, it is crucial to promote business endeavours. This study aims to assess students' understanding and approval of entrepreneurship-related topics in connection to their personal entrepreneurial tendencies and characteristics due to the pressing nature of the issue. 252 undergraduate students took part in the study by filling out self-administered questionnaires. The study showed a significant link between individuals' perception of their own expertise and their willingness to embrace entrepreneurship-related matters, which in turn impacts students' tendencies and traits associated to entrepreneurship. The pupils showed a strong inclination towards entrepreneurship, displaying characteristics such as open-mindedness, excellent cooperation, self-motivation, and a competitive spirit. These insights will help colleges develop entrepreneurship programmes to provide students with more entrepreneurial education and inspire them to pursue business opportunities.
Samorząd metropolitalny budowany od zadań
Authors: Redakcja RRPR
Published: April 2024

Książka jest efektem współpracy środowiska naukowego, eksperckiego i administracyjnego, funkcjonującego w ramach Metropolitalnej Sieci Współpracy Naukowej i Eksperckiej – koordynowanej przez Instytut Metropolitalny w Gdańsku.
Into the Negative (Space): Images of War Across Generations in Portugal and Guinea-Bissau. Death is Not the End
Authors: Barroca Daniel
Published: April 2024

I compare a photo album of the war in former Portuguese Guinea that I found in my home when I was a child with a collection of writings by Victor Bor, a healer and diviner whom I met in southern Guinea-Bissau who was a guerrilla during that country’s war of liberation and who was possessed by a vision that the Balanta people call Kyangyang [The Shadow]. I discuss the visuality and tactility of these two complex assemblages of images as tangible negative spaces that capture and shape the gaze. How do certain images have the power to enthrall, to trap the viewer? How can they intoxicate and mobilize into gang murder in a wartime setting? At the same time, I discuss the layers and characters that the gaze assumes in order for someone to create these images, and how they materialize a kind of exchange between generations. What is it that crosses the gaze of a previous generation through its images of violence? Yet, in parallel, there is the stunning effect of looking at shocking images of war, as opposed to being stunned by visions of lights and explosions that compel shocking actions in a post-war environment.
Does an episode of diabetic ketoacidosis affect thyroid function tests in pediatric patients?
Authors: Atakul Gülhan , Korkmaz Huseyin Anıl , Gönüllü Ahmet , Sandal Özlem Saraç , Köprülü Özge , Uyar Nilüfer , Karaaslan Utku , Apa Hurşit , Ağın Hasan , Özkan Behzat
Published: April 2024

Objectives

The aim of our study was to investigate the changes in thyroid hormone levels during and after acute metabolic disorder in patients with diabetic ketoacidosis (DKA).

Methods

Eighty five patients diagnosed with DKA were included in the study. Patients with control thyroid function test (TFT) values at admission (the first blood sample) and 1 month later were included in the study. Thyroid function tests obtained during diabetic ketoacidosis and at the first month follow-up were compared. Euthyroidism and euthyroid sick syndrome were defined and grouped according to current guidelines. The mild and moderate groups, according to DKA classification, were combined and compared with the severe group.

Results

A significant increase was observed between the first admission and the control TFT values 1 month later. However, there was no significant difference found in TFT between mild/moderate and severe groups taken at the time of DKA. Difference between two groups, euthyroid sick syndrome and euthyroid, was examined and the result that was different from the literature was the difference between TSH levels. We found that low FT4 levels were associated with higher HgbA1c, although the correlation was weak.

Conclusions

Thyroid hormone levels may not reflect a thyroid disease during severe DKA attack. Therefore, it is unnecessary to check thyroid function tests.
Crystal structure of poly[μ10-4,4′-methylene-bis(oxy)benzoatodipotassium], C15H10K2O6
Authors: Wu Ting T. , Gu Si N. , Ou Zhi Y. , Nie Ting Y. , Liu Yang
Published: April 2024

C15H10K2O6, orthorhombic, Pna21 (no. 33), a = 11.4410(13) Å, b = 3.9881(5) Å, c = 32.465(4) Å, V = 1481.3(3) Å3, Z = 4, R
gt(F) = 0.0356, wR
ref(F
2) = 0.0918, T = 296.15 K.
Experimental research of paraffin deposition with flow loops
Authors: Gao Chang Hong
Published: April 2024

Wax/paraffin deposition in production wells and oil pipelines is a major challenge for oil production. Extensive research has been conducted to improve understanding of this process. This paper presents a review of experimental work carried out with flow loops. Previous research investigated paraffin deposition process under the influences of temperature, flow rate/velocity, shear stress, water fraction, gas phase, pipe material, asphaltene concentration, and chemical inhibitors. Test results reveal that temperature and shear stress have significant impacts on wax deposition. Limited research has been conducted on wax deposition under multiphase flow. Even though more than 20 years of efforts have been spent on wax deposition studies, unfortunately we have not fully understood this phenomenon.
A molecular mechanics implementation of the cyclic cluster model
Authors: Samaniego-Rojas Juan Diego , Gaumard Robin , Alejandre José , Mineva Tzonka , Geudtner Gerald , Köster Andreas M.
Published: April 2024

The implementation of the cyclic cluster model (CCM) for molecular mechanics is presented in the framework of the computational chemistry program deMon2k. Because the CCM is particularly well-suited for the description of periodic systems with defects, it can be used for periodic QM/MM approaches where the non-periodic QM part is treated as a defect in a periodic MM surrounding. To this end, we present here the explicit formulae for the evaluation of the Ewald sum and its first- and second-order derivatives as implemented in deMon2k. The outlined implementation was tested in molecular dynamics (MD) simulations and periodic structure optimization calculations. MD simulations of an argon system were carried out using the Nosé-Hoover chain (NHC) thermostat and the Martyna-Tobias-Klein (MTK) barostat to control the temperature and pressure of the system, respectively. For the validation of CCM structure optimization a set of molecular crystals were optimized using the Ewald method for the evaluation of the electrostatic interactions. Two optimization procedures for the determination of the atomic positions and CCM cell parameters were tested. Our results show that the simultaneous optimization of the atomic positions and cell parameters is most efficient.
A computational characterization of N-heterocyclic carbenes for catalytic and nonlinear optical applications
Authors: Alauddin Mohammad , Islam Mazharul M.
Published: April 2024

Very recently, N-heterocyclic carbenes (NHCs) have found a wide range of applications in the fields of catalysis and nonlinear optics. Herein, we have employed 1,3-bis-(1(S)-benzyl)-4,5-dihydro-imidazol-based carbene as a reference molecule and substituted one H atom from each CH2 of the benzyl groups in both sides by CH3, NH2, and CF3 to study the thermodynamic and opto-electronic properties of NHCs theoretically. It was observed that the enthalpy (H), Gibb’s free energy (G), specific heat capacity (C
v), and entropy (S) increase significantly in the presence of the electron-withdrawing groups compared to the electron-donating groups. The IR active in-plane bending vibrations of the CH (NHC) group are shifted to the higher frequency region for the considered substituted molecules compared to the reference carbene. The analysis of the electronic properties shows that the CH3-substituted carbene is more reactive for catalytic activities compared to other NHCs. The calculated nonlinear optical (NLO) properties reveal that the NH2-substituted NHC has the largest hyperpolarizability value whereas the CH3-substituted NHC has the largest dipole moment and polarizability among all, making them potential candidates for the development of NLO materials.
From Cs[C2N3] to Cs3[C6N9] – a thermal and structural investigation
Authors: Reckeweg Olaf , DiSalvo Francis J. , Dinnebier Robert E. , Funk Christian , Schleid Thomas
Published: April 2024

Cesium dicyanamide Cs[C2N3] (≡ Cs[N(CN)2] or Cs[dca]) was obtained by a metathesis reaction in form of transparent colorless platelets. The results of single-crystal X-ray structure measurements and refinements (C2/c, Z = 8) with the monoclinic cell parameters a = 932.31(8), b = 1274.67(9), c = 824.94(7) pm, β = 110.803(3)° at −70 °C and a = 939.59(7), b = 1281.58(8), c = 827.57(6) pm, β = 110.610(3)° at 20 °C corroborate earlier results for this compound. The Raman and IR spectra of Cs[C2N3] are presented for the first time and the result compares well with those of NaCs2[C2N3]3. The heat-driven cyclotrimerization process of Cs[C2N3] was studied by thermal analyses (DSC) and temperature-dependent X-ray powder diffraction methods. At 370 °C, its trimerization product Cs3[C6N9] is formed, crystallizing in the orthorhombic space group Pbam with the cell parameters a = 3043.0(3), b = 1052.4(1) and c = 415.21(4) pm for Z = 4. The IR spectrum of this cesium tricyanomelaminate (Cs3[C6N9] or Cs3[TCM]) is presented, but a well-resolved Raman spectrum could not be acquired owing to fluorescence phenomena. An overview about the cyclotrimerization reactions of all pseudo-binary alkali-metal dicyanamides (A[C2N3]) to their corresponding tricyanomelaminates (A
3[C6N9]) with A = Li–Cs gives a basis for a discussion of the different thermal and structural characteristics.
A Study on the Damage Behavior of Hybrid 60 and 52100 Steel during Rolling Contact Fatigue
Authors: Loaiza Tania , Ooi Steve , Babu Revathy Rajan Prasath , Ölund Patrik , Hedström Peter
Published: April 2024

This study investigates and compares the evolution of subsurface hardness and microstructure of Hybrid 60 and 52100 steels under rolling contact fatigue (RCF) testing. Similar microstructural decay was identified for both Hybrid 60 and 52100 steel, evidenced by the formation of elongated ferrite and ferrite microbands during the first stage of the microstructural decay. Nano-sized ferrite grains were also observed in the region with maximum Hertzian stress after 1 × 108 stress cycles for both steels. In addition to the common microstructural decay in the two steels, the 52100 steel experienced microstructural decay in the form of dissolution of residual cementite and tempered carbides. The present study shows that the Hybrid 60 steel develops less microstructural decay than the 52100 steel at the same RCF conditions suggesting that Hybrid 60 could be suitable for replacing 52100 in applications where higher RCF is needed. The improved microstructure stability in Hybrid 60 is attributed to the more stable secondary carbides and intermetallic precipitates as compared to the cementite in the 52100 steel.
Material Behavior of Case Carburized Bearings Subjected to Standing Contact Loading Conditions
Authors: Lai Junbiao , Kadin Yuri , Volkmuth Markus , Tanke Jesko-Henning
Published: April 2024

This paper reports on a study of the material behavior of case-carburized components subjected to standing contact loads. Numerical simulation by means of finite element analysis (FEA) was performed to understand the material response in terms of plastic deformation and the induced damage in the subsurface region of case-hardened components with a hardness profile characterized by surface hardness, core hardness, and case depth. Based on a parametric study that considered different hardness profiles and contact loading conditions, a model was developed to evaluate the depth of surface plastic indentation and material damage resulting from standing contact loads. Standing contact fatigue tests were carried out on a carburized block specimen, as well as on the inner ring of a case-carburized cylindrical roller bearing. The model prediction agreed well with the experimental results. The work presented here provides a method to evaluate the performance of case-carburized bearings subjected to standing contact loads.
Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine
Authors: Breitwieser Gerda E. , Cippitelli Andrea , Wang Yingcai , Pelletier Oliver , Dershem Ridge , Wei Jianning , Toll Lawrence , Fakhoury Bianca , Brunori Gloria , Metpally Raghu , Carey David J. ,   the Regeneron Genetics Center, Robishaw Janet
Published: April 2024

GPR37L1 is an orphan receptor that couples through heterotrimeric G-proteins to regulate physiological functions. Since its role in humans is not fully defined, we used an unbiased computational approach to assess the clinical significance of rareG-protein-coupled receptor 37-like 1(GPR37L1) genetic variants found among 51,289 whole-exome sequences from the DiscovEHR cohort. RareGPR37L1coding variants were binned according to predicted pathogenicity and analyzed by sequence kernel association testing to reveal significant associations with disease diagnostic codes for epilepsy and migraine, among others. Since associations do not prove causality, rareGPR37L1variants were functionally analyzed in SK-N-MC cells to evaluate potential signaling differences and pathogenicity. Notably, receptor variants exhibited varying abilities to reduce cAMP levels, activate mitogen-activated protein kinase (MAPK) signaling, and/or upregulate receptor expression in response to the agonist prosaptide (TX14(A)), as compared with the wild-type receptor. In addition to signaling changes, knock-out (KO) ofGPR37L1or expression of certain rare variants altered cellular cholesterol levels, which were also acutely regulated by administration of the agonist TX14(A) via activation of the MAPK pathway. Finally, to simulate the impact of rare nonsense variants found in the large patient cohort, a KO mouse line lackingGpr37l1was generated. Although KO animals did not recapitulate an acute migraine phenotype, the loss of this receptor produced sex-specific changes in anxiety-related disorders often seen in chronic migraineurs. Collectively, these observations define the existence of rareGPR37L1variants associated with neuropsychiatric conditions in the human population and identify the signaling changes contributing to pathological processes.
Corruption and Human Rights in the Dimension of Pancasila Values
Authors: Falah Muchamad Fajrul
Published: April 2024

Pancasila is the source of all laws in Indonesia, all regulations made in Indonesia are all based on the values contained in Pancasila. Corruption is a criminal act committed by a person or group of people by taking rights that should belong to the state or society for personal purposes. Corruption is also one of the factors that hinders the economy of a country, can also reduce the country's economy and increase the level of poverty. The act of corruption is an act of serious human rights violation, because it deliberately seizes the property rights of others. This criminal act of corruption usually occurs because of the abuse of power, trust, authority, and the weakness of the law in this country.
Challenges and Dilemmas Faced by Labor Market Integration Support Providers in Portugal
Authors: Martinho Ana Luisa
Published: April 2024

This research delves into the challenges and dilemmas faced by both professionals and people in vulnerable situations in the process of social and professional inclusion. Grounded in a theoretical framework that underscores the persistent rates of labor exclusion among specific social groups and the fragmented social policies in Portugal, the study aims to understand the structural framework and practices in this field.
This research adopts a qualitative approach to investigate the challenges of the social and professional integration of people in vulnerable situations. For this purpose, the study employs nine in-depth case studies within the context of social economy organizations in Portugal.
The findings illuminate the complex challenges faced by professionals supporting people with complex needs, including the nonlinearity and multifaceted nature of the inclusion process, resource inadequacies, the need for specialized training and guidance, and a labor market unaligned with the needs and abilities of the clients. The study underscores the necessity for a more holistic, supportive, and inclusive approach to address the intricate dynamics of social and professional integration for people in vulnerable situations.
Evolution of the concept of the absolute in Fiche
Authors: NETREBIAK Olha
Published: April 2024

The article offers an analysis of the concept of the Absolute in Fichte’s philosophy. Despite the difficulty of the definition, this concept receives a rich and creative rethinking in Fichte and will further influence the philosophical systems of thought. Gradually introducing this concept into his philosophical project of Wissenschaftslehre Fichte often changes its interpretation. So, starting with a somewhat vague understanding of the concept of the "absolute I" through Schelling's criticism of the Absolute, he develops the theory of the manifestation of the Absolute, each time choosing new metaphors to denote it, and sometimes filling it with religious content, when the Absolute becomes a substitute for the concept of God. On the one hand, it’s important not to reduce the Absolute to a simple object of thought because this would indicate the limitation of the Absolute. On the other hand, it would be wrong to consider the Absolute as an empty or neutral concept or something completely enclosed in itself. Then, its existence will be doubtful. Fichte is careful about a clear definition of the Absolute. He solves this dilemma through the idea of the manifestation of the Absolute. Manifestation is the exit of the Absolute beyond itself while remaining unchanged. The ability to manifest itself is a prerequisite that the Absolute can be recognized and thought. This is how the Absolute manifests itself in the form of knowledge. Fichte emphasizes that the Absolute is not a projection of our mind, it may not depend on our thinking, however with such peculiarity that truth and knowledge have their basis in it. Thereby, with the theory of the Absolute, Fichte develops the idea of the foundation that is outside of ourselves, has transcendental character, and thus allows knowledge or truth not to be trapped in subjective tenets. Analyzing step by step the process of evolution of this concept, we will be able to see how in the last years of his life, Fichte states the importance of two realities: the “I” and the “Absolute” and how he explains the connection between them.
MATHEMATICAL MODEL OF A MAGNETOELECTRIC MACHINE
Authors:   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine, Kondratenko I.P. , Kryshchuk R.S. ,   Institute of Electrodynamics National Academy of Sciences of Ukraine, Beresteiskyi Ave., 56, Kyiv, 03057, Ukraine
Published: April 2024

A mathematical model is proposed for the calculation of electromagnetic parameters of magnetoelectric machines using an analytical method. Permanent magnets are abstracted as equivalent solenoids with constant current represented as current loops. The model differs from known models by the presence of double linear current loops in the stator for the analysis of magnetoelectric machines with a two-layer winding. Additionally, the proposed model considers linear current loops of equivalent solenoids instead of point current loops for a more accurate calculation. The current loops of the stator and rotor are defined at the boundaries of the air gap of the electric machine, i.e., on the smooth slotless surfaces of the magnetic cores. The current loops are expressed for the first time as a product of three variables: current strength, linear current density coefficient, and spatial distribution coefficient. The inductance of stator slots and the resistance of the winding are taken into account using known analytical expressions from classical electric machine theory. The rotor rotation frequency is presented as a function of time. For magnetoelectric machines of specified dimensions and a given variable rotor rotation frequency, the distribution of magnetic field induction, vector magnetic potential, currents, winding spatial distribution coefficients, and electric field intensity of permanent magnets are calculated using the mathematical model. References 7, table 1, figures 4.
NEOMANAGEMENT, EL LADO OSCURO DE LAS ORGANIZACIONES Y EL CONFLICTO TRABAJO-FAMILIA: REFLEXIONES CRÍTICAS Y PROPUESTAS DE LÍNEAS DE INVESTIGACIÓN
Authors: Jiménez Figueroa Andrés , Gómez Urrutia Verónica
Published: April 2024

En este trabajo se examinan los alcances conceptuales y prácticos de una nueva forma de gestión empresarial denominada por algunos autores como neomanagment. Desde la perspectiva de esta filosofía de trabajo, se realiza una reflexión crítica a la situación actual de la gestión organizacional a la luz del impacto de los cambios propios en la concepción del trabajo humano. En este trabajo se examina críticamente la propuesta de estudio de los fenómenos presentes en el denominado “lado oscuro de la organización”. De acuerdo a Linstead, Maréchal y Griffin (2014), se tiende a ignorar los elementos éticos, políticos e ideológicos presentes en las organizaciones al privilegiar paradigmas teóricos sin visualizar las consecuencias disfuncionales del comportamiento organizacional. Desde la perspectiva del cuestionamiento de los modelos existentes en la temática, se propone una revisión metodológica de investigación que incorpore los aportes derivados de enfoque marxistas, post-marxistas y postcoloniales.  Se analizan las implicancias prácticas de esta nueva perspectiva que considera problemas presentes en el comportamiento organizacional, que tradicionalmente han sido obviados en las teorías organizacionales. Se concluye la necesidad de fomentar una actitud crítica, ética y renovada visualizando las necesidades organizacionales, a través de una lectura sistemática de los cambios que están por venir.
DISEÑO DE UNA MATRIZ DE CONSISTENCIA PARA LA IMPLEMENTACIÓN DE LA ÉTICA EN LA AUDITORÍA
Authors: Blanco Alfaro Cristian , Cortés Iturrieta Patricia
Published: April 2024

Mucho se ha debatido si es suficiente que la ética sea impartida sólo como una asignatura en los Planes de Estudios de las universidades o ésta también, deba ser implementada a través de la línea de formación profesional de las carreras. La Carrera de Auditoría de la Universidad estudiada, ha declarado la necesidad de que esta competencia sea desarrollada de manera transversal. De allí que se exista una preocupación por subsanar uno de los vacíos detectados en su última acreditación, donde se revela la necesidad de una mayor articulación de la ética con las asignaturas del área profesional. Es sobre esta base, que emerge esta investigación, centrándose en diseñar una matriz de consistencia que permita articular la ética con los resultados de aprendizajes declarados en el área específica de la Auditoria. La metodología de este proyecto, presenta un enfoque cualitativo, un diseño de investigación-acción, y considera entrevistas a agentes claves (auditores), entrevista semiestructurada a la Directiva (o) de Carrera y análisis documental a programas de asignaturas del área de Auditoría. Los resultados, señalan la relevancia que adquiere la ética en el área de la Auditoría en función de cinco principios: Integridad, objetividad, confidencialidad, diligencia profesional y autonomía, a su vez, que revela la importancia de asociarla con la normativa vigente en el proceso de auditar y con los procedimientos que subyacen al desempeño profesional. Sobre la base de estos resultados, se logra articular la ética con los aprendizajes esperados del área de la Auditoría, generando una matriz de consistencia que parte por la necesidad de comprender la asociación inherente entre los principios éticos y las normativas vigentes en esta área, siguiendo por la valoración que adquiere la ética como parte de la conducción del Auditor.
La comunicación como eje articulador en la interpretación del patrimonio natural y cultural
Authors: Orellana Mcbride Arlyn Estefanía , Aguilera Aguirre Daniela Belén , Villar Castillo María del Pilar , Salfate Kastner Bastián Patricio
Published: April 2024

En la presente investigación se abordan cuáles son los elementos de la comunicación social presentes en la interpretación del patrimonio natural y cultural de la Reserva Pingüino de Humbolt (Región de Coquimbo), así como la comprensión sistémica de su relación para la entrega exitosa del mensaje. Por lo tanto, se tiene en consideración lo que significa una reserva nacional en una localidad donde la mayoría de sus habitantes tienen como sustento el turismo y la pesca artesanal, bases del desarrollo de la localidad, como también, las fuentes de sus oportunidades. Los objetivos son analizar y comprender la relación entre el territorio, en el que confluyen el patrimonio natural y el cultural, con la condición de bienestar de una comunidad y el rol de la comunicación en esta relación simbiótica.  Existe una necesidad urgente de desarrollar capacidades científicas, técnicas e institucionales que originen un entendimiento básico capaz de planificar las medidas adecuadas en relación al cuidado y preservación de la biodiversidad. Y, añadimos, sin comunicación de las mismas, no es posible conseguir los objetivos determinados.
Estenosis distal del conducto biliar común por coinfección de citomegalovirus y Cryptosporidium spp. en síndrome de inmunodeficiencia adquirida. Reporte de un caso
Authors: Rodríguez-Gutiérrez Andrés Fernando , Remolina-Granados Sergio Andrés , Vallejo-Ávila Sergio Andrés , Viveros-Carreño Juan Manuel , Martínez-Baquero Diana Lucia
Published: April 2024

Resumen
Introducción. La colangiopatía por síndrome de inmunodeficiencia adquirida es infrecuente y presenta una alta morbilidad. La estenosis del conducto biliar común (colédoco) y la colangitis esclerosante secundaria son sus formas más comunes, generalmente causadas por infecciones oportunistas.
Presentación del caso. Hombre de 27 años diagnosticado con síndrome de inmunodeficiencia adquirida, sin terapia antirretroviral al momento de su ingreso, quien consultó a un hospital de tercer nivel de complejidad en la ciudad de Bogotá por dolor en hipocondrio derecho y diarrea crónica de tres semanas de evolución. Se realizó coprocultivo que fue positivo para ooquistes de Cryptosporidium spp. Las pruebas de fosfatasa alcalina y gamma-glutamil transferasa evidenciaron una elevación en los valores. Adicionalmente, se practicó una colangiografía por resonancia magnética que mostró dilatación de la vía biliar por estenosis distal del conducto biliar común. La colangiopancreatografía retrógrada endoscópica confirmó el hallazgo y descartó una colangitis esclerosante. Se realizó la inserción de un stent biliar (endoprótesis) y se solicitó biopsia de la ampolla de Vater que mostró estructuras citomegálicas con inclusiones intracelulares. El diagnóstico final fue colangitis por citomegalovirus y Cryptosporidium spp., por lo que se inició terapia antirretroviral y tratamiento antiviral (ganciclovir) con evolución satisfactoria.
Conclusiones. La colangiopatía es una de las causas de dolor abdominal en pacientes con síndrome de inmunodeficiencia adquirida. El citomegalovirus y el Cryptosporidium spp. son los agentes etiológicos más frecuentes. El manejo se basa en la resolución de la estenosis por vía endoscópica, la terapia antirretroviral y el tratamiento antimicrobiano dirigido.
Probability of a high recurrence score for breast cancer on the Oncotype DX test in males: a case series
Authors: Assunção Ribeiro da Costa Rafael Everton , Rocha de Oliveira Fergus Tomás , Amaral dos Reis Cristiane , Carlos Vieira Sabas
Published: April 2024

Abstract
Introduction: Male breast cancer (MBC) is a rare disease that accounts for 1% of breast cancers. The Oncotype DX test (a genomic signature that assesses the expression of 21 genes to estimate the recurrence score [RS]) has been widely used in MBC to select patients for adjuvant chemotherapy.
Objective: To describe 5 cases of MBC in which a nomogram was used to predict the probability of having a high Oncotype DX score for breast cancer and the need to perform genomic signature.
Materials and methods: Case series study in which five patients with MBC treated between 2007 and 2020 at a cancer institution in Teresina (Brazil) were included. A nomogram was performed to evaluate five clinical and pathological variables (age, body size, tumor size, grade, recurrence score status, and histologic type of carcinoma).
Case series: The mean age of the patients at diagnosis was 69 years (mean tumor size: 2.6cm). All patients received hormone therapy with tamoxifen, three received chemotherapy, and one received radiation therapy after breast surgery (mastectomy). During a median follow-up period of 88 months, one case had a recurrence (bone metastasis). Based on the nomogram results, two patients had a high probability of a high RS (36% and 45%) and only one patient (case 3) underwent Oncotype DX testing (RS: 20).
Conclusions: In the present series of five cases, based on the nomogram results, only two patients (cases 3 and 4) had a high probability of a high Oncotype DX recurrence score; however, due to financial constraints, this test was only performed on one of these two patients. The patient who underwent the test (case 3) did not receive adjuvant chemotherapy and remained alive with bone metastases until the end of the follow-up period. Conversely, the patient who could not undergo the examination (case 4) received adjuvant chemotherapy and was alive without any signs of disease.