bluuebunny/crossref_metadata_2025 huggingface dataset:
Verbalization of corporality in blockade texts
Authors: Efremov Valerii A. , Popovich Daria A.
Published: March 2023

Modern philology is increasingly turning to interdisciplinary problems, which include corporality, which is studied at the intersection of biology, medicine, cognitive science and philosophy. At the same time, the interest of linguistics in the conceptualization and verbalization of bodily and psychological individual experience leads to the need to study ego-documents that tell about the most difficult, traumatic life situations (hunger, war, disability, fatal illness, loss of loved ones, etc.). The purpose of the work is to explication of the specifics of the perception of the corporality of a resident of besieged Leningrad through the verbalization of one’s own and others’ bodily experience. The number of specific elements of the conceptualization of corporality (hunger, dystrophy, cold, trauma, etc.) were revealed. An analysis of the memories of the blockade survivors convincingly proves that the body was perceived by the starving inhabitants as deformed, destroyed and striving for inevitable death. Reflection on the body and corporality inevitably leads to the realization of the rigid connection of corporality with the psyche and morality. Such specific forms of comprehension and verbalization of the physicality of blockade runners as hunger trauma, winter trauma, and alienation of the body are identified and analyzed. The analysis of the traumatic bodily experience of the inhabitants of the besieged Leningrad can serve as a further development of linguistic studies of both corporality and traumatic experience.
National language in the history of Russian statehood
Authors: Mozgovoy Vladimir I.
Published: March 2023

The research relevance on the relationship between the national language and statehood is determined by intensification of contradictions in modern society associated with the neglect or selective attitude of politicians to certain processes of linguistic identification of an individual, people and state. The purpose of the study is to reveal the reasons for the ignorant nihilism of so-called “titular nation” in relation to the “undeveloped” or “non-indigenous” peoples. As an alternative, a project is proposed for the creative construction of the Russian state on the basis of preserving the right of each peoples to their own culture as part of national language. Its special status is not always associated with the point date of the emergence of a nation or a particular national language in the era of capitalism. It is determined by long process of formation of the original language culture, starting from Ancient Rus’ and the formation of the Russian Empire up to the present, characterized by devastating consequences of an unprofessional view of the problem of language construction. Free interpretations of the concepts of state, regional, non-territorial languages, languages of nationalities or native language and attempts to fit the norms of modern state life under the category of exclusivity of a certain nationality, one ruling class, one religion or language of communication in the conditions of interpenetration and interdependence of modern cultures are criticized. As a conclusion, ways are proposed to restore the traditional model of Russian statehood, associated with the preservation of multicultural and multinational community, materialized in the national language.
Determinação social do ser cuidador
Authors: Pereira Vinícius Araújo , Serrano Luzia Cristina de Almeida , Silva Renato Ferreira da
Published: March 2023

Este artigo aborda as determinações sociais do ser cuidador, dos aspectos mais amplos à sua inserção e particularidades no âmbito do tratamento em transplantes. Com base em pesquisa documental e bibliográfica sobre o presente tema e através do método materialista histórico dialético e observação participante oriunda de aperfeiçoamento/especialização profissional em Serviço Social na Saúde em unidade de transplantes, este artigo objetiva problematizar os processos que condicionam o cuidador, evidenciando a insuficiência de compreensões que reduzem este sujeito a uma compreensão abstrata ou de um mero agente estratégico para tratamentos, em especial de transplantes. Dentre as diversas abstrações críticas realizadas, destaca-se a incontornável dinâmica sócio-histórica do modo de produção capitalista no que tange as determinações sociais que condicionam o ser cuidador, as múltiplas categorias intrínsecas de sua vivência e o próprio tratamento em transplante.
Asas Keseimbangan Dalam Perjanjian Pengadaan Barang/Jasa Pemerintahan Berdasarkan Perpres No 12 Tahun 2021
Authors: Kinasih Mahaneni Rosaning , Siswanto Abirama Adibrata
Published: March 2023

Pelaksanaan pembangunan fasilitas publik pada umumnya dilaksanakan oleh pemerintah melalui kerjasama dengan perusahaan-perusahaan yang bergerak dalam bidang pengadaan barang/jasa. Salah satu asas yang sangat penting namun sulit untuk diwujudkan dalam perjanjian pengadaan barang/jasa pemerintah adalah asas keseimbangan. Asas keseimbangan mengamanatkan adanya keseimbangan hak dan kewajiban bagi para pihak dalam perjanjian. Namun pada praktinya, perusahaan selaku penyedia barang/jasa cenderung memiliki posisi yang tidak seimbang pada saat menjalin kerjasama dalam pengadaan barang/jasa pemerintah. Oleh karenanya, dipandang perlu melakukan suatu pengkajian terutama terkait dengan asas keseimbangan dalam perjanjian, serta perwujudan asas keseimbangan dalam perjanjian pengadaan barang/jasa pemerintah pada Perpres No. 16 Tahun 2018 Jo. Perpres No. 12 Tahun 2021. Pengkajian/pembahasan ini bertujuan untuk menganalisa lebih lanjut mengenai asas keseimbangan dalam perjanjian, serta perwujudan asas keseimbangan dalam perjanjian pengadaan barang/jasa pemerintah sebagaimana Perpres No. 16 Tahun 2018 Jo. Perpres No. 12 Tahun 2021. Perwujudan asas keseimbangan dalam perjanjian pengadaan barang/jasa pemerintah berdasarkan Perpres No. 16 Tahun 2018 Jo. Perpres No. 12 Tahun 2021 sulit untuk terwujud. Keseimbangan yang dimaksud baik pada pembuatan perjanjian, isi perjanjian, dan pelaksanaan perjanjian. Hal tersebut disebabkan oleh beberapa hal seperti, hubungan hukum yang terbentuk antara pemerintah selaku pengguna barang/jasa dengan penyedia barang/jasa bukan hubungan kontraktual murni, tetapi di dalamnya juga berkaitan dengan hukum administrasi negara.
The Executorial Title of Fiduciary Guarantee in the Digitalization Era for Business Needs
Authors: Tambunan Martua Eka Wijaya , Famdale Grace Natalia Hengki , Syamsuddin  , Sinaga Abraham Pangihutan
Published: March 2023

This paper aims to address the issue of executorial title in Indonesia regarding the latest regulations in fiduciary whether it is still relevant to the development of increasingly advanced information technology. The number of fiduciary disputes in the Supreme Court brings out the fact that fiduciary regulation still does not fulfill the needs of the parties involved. With regard to that matter with the issuance of the Constitutional Court’s Decision Number 18/PUU-XVII/2019, the executorial title of the fiduciary certificate seems to be dwarfed. It is important that we identify and address the issues of fiduciary guarantee which are related to the regulation of the governance system in utilizing technology to facilitate and provide protection for investors to make the atmosphere of investment in Indonesia more interesting. The methodology that will be adopted in conducting this study would be a normative legal analysis of all laws and regulations regarding fiduciary guarantees that will provide insight to society and the government, especially stakeholders who are involved in the fiduciary guarantee agreement. We hope to recommend through this paper that specific legislation be created to improve the social and legal protection of business people in order for them to be able to conduct safely and freely business activities in the investment climate of the financial industry which has the potential to boost the Indonesian economic growth.
Extracellular Vesicles in Phytopathogenic Fungi
Authors: Rutter Brian D. , Innes Roger W.
Published: March 2023

Extracellular vesicles (EVs) are nano-sized, lipid compartments that mediate the intercellular transport of lipids, proteins, nucleic acids and metabolites. During infectious diseases, EVs released by host cells promote immune responses, while those released by pathogens attempt to subvert host immunity. There is a growing body of research investigating the role of fungal EVs in plant pathosystems. It is becoming clear that EVs released by fungal phytopathogens play a role during infection through the transport of protein effectors, toxic metabolites and RNA. Here, we discuss recent findings on EVs in fungal phytopathogens, including the methods employed in their isolation, their characterization, contents and functionality, as well as the key questions remaining to be addressed.
Analysis of Public Discourse on Twitter involving COVID-19 and MPox: Findings from Sentiment Analysis and Text Analysis
Authors: Thakur Nirmalya
Published: March 2023

Mining and analysis of the Big Data of Twitter conversations have been of significant interest to the scientific community in the fields of healthcare, epidemiology, big data, data science, computer science, and their related areas, as can be seen from several works in the last few years that focused on sentiment analysis and other forms of text analysis of Tweets related to Ebola, E-Coli, Dengue, Human papillomavirus (HPV), Middle East Respiratory Syndrome (MERS), Measles, Zika virus, H1N1, influenza-like illness, swine flu, flu, Cholera, Listeriosis, cancer, Liver Disease, Inflammatory Bowel Disease, kidney disease, lupus, Parkinson's, Diphtheria, and West Nile virus. The recent outbreaks of COVID-19 and MPox have served as "catalysts" for Twitter usage related to seeking and sharing information, views, opinions, and sentiments involving both these viruses. While there have been a few works published in the last few months that focused on performing sentiment analysis of Tweets related to either COVID-19 or MPox, none of the prior works in this field thus far involved analysis of Tweets focusing on both COVID-19 and MPox at the same time. With an aim to address this research gap, a total of 61,862 Tweets that focused on Mpox and COVID-19 simultaneously, posted between May 7, 2022, to March 3, 2023, were studied to perform sentiment analysis and text analysis. The findings of this study are manifold. First, the results of sentiment analysis show that almost half the Tweets (the actual percentage is 46.88%) had a negative sentiment. It was followed by Tweets that had a positive sentiment (31.97%) and Tweets that had a neutral sentiment (21.14%). Second, this paper presents the top 50 hashtags that were used in these Tweets. Third, it presents the top 100 most frequently used words that are featured in these Tweets. The findings of text analysis show that some of the commonly used words involved directly referring to either or both viruses. In addition to this, the presence of words such as "Polio", "Biden", "Ukraine", "HIV", "climate", and "Ebola" in the list of the top 100 most frequent words indicate that topics of conversations on Twitter in the context of COVID-19 and MPox also included a high level of interest related to other viruses, President Biden, and Ukraine. Finally, a comprehensive comparative study that involves a comparison of this work with 49 prior works in this field is presented to uphold the scientific contributions and relevance of the same.
Ulusal Bütçe Sürecine Vatandaş Katılımı Ve Araçlarının Değerlendirilmesi
Authors: GÜNEŞ Vuslat
Published: March 2023

Bugüne kadar kamu bütçe sürecine vatandaş katılımına ilişkin deneyimlerin çoğunun yerel yönetimler düzeyinde gerçekleştiği görülmektedir. Ancak günümüzde Dünya Bankası ve IMF gibi uluslararası kuruluşlar tarafından ulusal bütçe sürecinde katılımcı bir yaklaşım sergilenmesi gerekliliğine ilişkin vurgu artmaktadır. Ulusal bütçe sürecine vatandaş katılımının sağlanabilmesi için yasama organlarının, yürütme organlarının ve yüksek denetim kurumlarının bütçe sürecinin farklı aşamalarına ilişkin çeşitli mekanizmalar geliştirmeye başladığı görülmektedir. Ulusal bütçe sürecine vatandaş katılım düzeyini araştırmak için “Uluslararası Bütçe Ortaklığı (IBP)” tarafından “Açık Bütçe Anketi (OBS)” araştırması yapılmaktadır. Bu araştırma ulusal bütçe sürecine vatandaş katılımını küresel düzeyde ölçen tek araştırmadır. OBS 2021 sonuçları, araştırmaya dahil edilen ülkelerin büyük çoğunluğunun bütçe sürecine vatandaş katılımı konusunda iyi durumda olmadığını göstermektedir. Bu çalışma ile ulusal bütçe sürecine vatandaş katılımını sağlayan araçların neler olabileceğinin araştırılması amaçlanmıştır.
POLİTİK YARGI SORUNU EKSENİNDE BİR ARENDT KANT OKUMASI
Authors: SALMAN Selda
Published: March 2023

Arendt ve Kant arasındaki ilişki genellikle Arendt’in 1970’de New School’da verdiği derslerden derlenen Kant’ın Siyaset Felsefesi Üzerine Dersler’ine odaklanarak ele alınır ve Kant ile bağlantısı Arendt’in bu derslerde referans verdiği üzere Yargıgücünün Eleştirisi (Kritik der Urteilskraft) merkezinde değerlendirilir. Ancak Arendt üzerindeki Kant etkisinin izleri, burada olgunlaşmış düşünceleri de kapsayacak şekilde çok daha erken dönemden itibaren sürülebilir. Sistematik bir bütünlük arz etmese ve anlaşılması zaman zaman güç de olsa Arendt’in yazılarında Kant’ı bir milat olarak gördüğü ve transendental felsefenin temel ilkelerinin önemini teslim ettiği görülür. Arendt için Kant felsefe tarihinin en önemli dönüşümlerinden biri olan varlık ve düşünme arasındaki doğrudan bağlantıyı ve solayıısyla Platoncu bir yaklaşımla felsefeyi ayrıcalıklı insanların tekelinde salt bir düşünme faaliyeti olarak algılamayı böylelikle ortadan kaldırmış, ayrıca seküler, “şimdi” ve “burada” olana ilişkin politik yargıda bulunabilmenin imkanını ortaya çıkarabilecek temelleri atmıştır. Bu temellerin açığa çıkarılmasında Arendt yüzünü güzele ilişkin reflektif yargılarda betimlendiği şekliyle Kant’ın yargıgücüne dönmüştür. Arendt’de yargıgücü, yirminci yüzyılda dehşet verici boyutlara ulaşan bir mefhum olan “kötülüğün sıradanlığını” anlamada hem neden tespitini kolaylaştıran hem bir çözüm sunan bir yeti olarak öne çıkar. Aynı zamanda yargı yetisi insanı deterministik bağlantılarla ele almama ve eylemlerdeki sorumluluğun ehliyetinin taşınması anlamında da önemli bir noktada durur. Ancak yargıgücü verili ve belirlenmiş, nesnel bir yapıya sahip olmadığı için gelişmesi toplumsal iletişimi ve deneyimi gerektirir. Bu da ancak düşüncelerin kamusal alanda dolaşıma girebildiği bir özgürlük ortamı ile mümkündür. Bu çalışmada Arendt ve Kant arasındaki ilişki bir hata tespiti olarak düşünmenin politika alanında yetersiz kalması ve tikel eğilimlerin düşünmenin önüne geçmesiyle ortaya çıkan bir olgu olarak kötülük problemine ilişkin yargıgücü merkezli çözüm önerisini ele alacaktır. Arendt’in yaklaşımının Kantçı kökenleri ortaya konularak iddia edilenin aksine Arendt’in siyaset felsefesi yorumunun Kant felsefesine bağlı, yaratıcı bir yorum olduğu ileri sürülecektir.
Spatial pattern of soil erosion using RUSLE model and GIS software at the Saf Saf watershed, Algeria
Authors: Khanchoul Kamel , Boukhrissa Zine El Abidine , Othmani Ouafa
Published: March 2023

Soil erosion is one of the problems threatening the Algerian environment. In agriculture, soil erosion leads to the thinning of the topsoil under the effect of the natural erosive forces of water, or under the effect of agricultural activities. The present study aims to estimate average soil loss rate and to identify vulnerable zones. Through the integration of RUSLE model at the Saf Saf watershed, various parameters are utilized such as the rainfall erosivity factor (R), soil erodibility factor (K), slope length - slope factor (LS), crop management factor (C) and practice management factor (P). All these parameters are prepared and processed through a geographic information system (GIS) and remote sensing using various database sources. The results reveal that the river basin has an average annual soil loss of 3.9 t ha−1 yr−1, and annual soil loss of 4.53 million tonnes for the period 1975-2017. Meanwhile, eighty five percent of the study area is experiencing acceptable rate of soil erosion loss, which is ranging between 0 to 5 t ha−1 yr−1. The present study of risk assessment can contribute to understand the spatial pattern of soil erosion in order to use appropriate conservation practices for sustainable soil management.
Using an Inventory of Unstable Slopes to Prioritize Probabilistic Rockfall Modeling and Acid-Base Accounting in Great Smoky Mountains National Park
Authors: O'Shea Thomas , Farmer Samantha , Nandi Arpita , Bilderback Eric , Luffman Ingrid , Joyner Andrew
Published: March 2023

An important first step in the geotechnical asset management of Great Smoky Mountains National Park (GRSM) is the creation of an unstable slope inventory along major transportation corridors. Slope-stability problems are frequent in GRSM, often initiated in highly weathered and fractured metasedimentary rocks. In this study, an unstable slope inventory was created using the Unstable Slope Management Program for Federal Land Management Agencies protocols. Hazards and risks were evaluated for 285 unstable slopes along 243.67 km of roadway. Kernel density estimation was used to identify unstable slope hotspots and establish 14 sites for site-specific investigations to evaluate potential impacts of discrete unstable slopes along major roadways. Two-dimensional probabilistic rockfall simulations and acid-base accounting tests were used to predict rockfall pathways and evaluate the acid-producing potential of rocks. Simulations indicated that rock material would likely enter the roadway at all 14 sites. Acid-base accounting test results indicated that slaty rocks of the Anakeesta Formation and graphitic schist of the Wehutty Formation are primary acid-producing rocks in rockfall-prone areas. This research illustrates an approach for prioritizing areas for site-specific investigations towards the goal of improving safety in GRSM, including developing mitigation strategies for rockfall by widening ditches, installing barriers, and encapsulating acidic rockfall material.
Plan de exportación de cacao orgánico tostado hacia Estados Unidos
Authors:   , Coronel Velarde Juan José , Pillaca Gamarra Liz Susy , Vásquez Huanca Vanessa Emperatriz , Vílchez Huatangari Emer Johan
Published: March 2023

La presente investigación presenta el diseño de un plan de exportación de cacao orgánico tostado hacia Estados Unidos; así, se plantearán puntos clave a tener en cuenta en este proceso de toma de decisiones que ha de considerar el exportador. Se está trabajando con el departamento de San Martín “uno de los mayores productores de cacao en el país y una de las regiones con el verdadero secreto de la buena calidad de cacao y chocolate peruano” (Agraria,2019); para nuestra propuesta en el distrito de San José de Sisa, que cuenta con condiciones idóneas para cultivo de estos sembríos. Estamos así mismo orientados como empresa a trabajar con cooperativas de la región y asociaciones de pequeños cultivadores del cacao para sean ellos nuestros principales proveedores, de esta manera potenciar la labor de estos agricultores con pedidos periodificados por hectárea para cubrir un mayor nivel de demanda por este producto.
Plan de negocio Kaprishosa
Authors:   , Cerna Romero Yusuke Abraham , Malpartida Maíz Oralea , Román Cordova Vitian Sugey , Manrique Castro Eduardo Tigran Nathaniel
Published: March 2023

La razón principal del presente plan de negocios es determinar la rentabilidad de la empresa, para lo cual aplicaremos estrategias innovadoras dentro del sector que pretendemos participar, Kaprichosa se dedicará a la negociación y comercialización de lencería comestible y personalizada; este modelo de negocio estará dirigido para ambos géneros, damas y caballeros. Empezaremos en la ciudad de Lima, para luego expandirnos a nivel nacional. Mediante un estudio de mercado y el análisis respectivo, aplicaremos las estrategias del negocio, para ofrecer un producto que pueda satisfacer esa demanda de clientes potenciales, este proyecto demostrara la rentabilidad que se desea tener, identificara las propuestas económicas así como también la capacidad financiera proyectada mediante nuestro análisis financiero, encontrar la optimización y equilibrio que se requiere para invertir y crear un negocio rentable que tenga las grandes posibilidades de crecimiento sostenible con el tiempo. Nuestros materiales serán reciclables y biodegradables lo que permitirá contribuir con la responsabilidad social, así como la protección del ecosistema para un mundo mejor. Lo cual será respaldado de las certificaciones y procedimientos establecidos para el desarrollo de los productos a ofrecer.
Asociación entre salud mental y actitudes ante el confinamiento durante la pandemia COVID-19 en hospitales de Lima y Callao
Authors:   , Burneo Ramírez María Claudia , Campos de la Cruz Iris del Carmen
Published: March 2023

Objetivo: Identificar la asociación entre la depresión, ansiedad y estrés con las actitudes ante el confinamiento durante la pandemia por COVID-19 en personal de salud del Hospital Nacional Daniel Alcides Carrión y Hospital Militar Central mediante el empleo de la escala DASS-21. Materiales y métodos: Estudio transversal, observacional y analítico, participaron personal de salud que trabajó en áreas Covid durante la pandemia COVID-19. Se empleó la escala Dass-21 para medir la existencia de estados emocionales de depresión, ansiedad y estrés, y la escala de actitudes adaptada frente al confinamiento para COVID-19. Resultados: Se incluyó 124 participantes, 54% (n=67) de sexo femenino, con una mediana de edad de 34.5 años [Ri]= 16.5 que reportaron una mediana de años de experiencia de 6 (Ri = 17). La mediana del puntaje de la Escala Dass-21 para ansiedad fue de 2 (Ri= 5), la mediana del puntaje de Dass-21 para depresión fue de 1 (Ri=4.5) y la mediana del puntaje de la Escala Dass-21 para estrés fue de 4 (Ri=5). El análisis bivariado entre los valores de los parámetros de la Escala Dass-21 y las demás covariables identificó que el grado de instrucción tenía una relación significativa con la subescala de depresión, ansiedad y estrés. Conclusión: Se encontró asociación entre los parámetros afectivos de la escala sobre actitudes ante el confinamiento y las tres subescalas de DASS-21.
Efecto de la acumulación de material particulado sobre la generación eléctrica de módulos fotovoltaicos en la ciudad de Lima, Perú
Authors:   , Mendiola Monsante María Lucia
Published: March 2023

La acumulación de polvo también conocido como material particulado (PM) en módulos fotovoltaicos (FV) tiene dos efectos principales; reduce la cantidad de luz que alcanza a las celdas fotovoltaicas e incrementa la temperatura de los módulos resultando en pérdidas de eficiencia. Este fenómeno es conocido como soiling en inglés. La cantidad de partículas acumulados y su efecto en la potencia de salida de dos módulos FV limpio y sucio fue evaluada entre junio y noviembre de 2019 en Lima, Perú. La taza de deposición de partículas, la temperatura y potencia de salida fueron registradas. Los resultados muestran que el polvo disminuye la potencia de salida levemente bajo clima nublado, común durante el invierno en la ciudad de Lima. Se determine que la potencia de salida del módulo sucio se vio significativamente reducida en hasta 49% y su temperatura aumentó en 7°C en días soleados. Los autores concluyeron que la acumulación de partículas impacta negativamente en la energía que producen los módulos FV y que la interacción entre partículas y humedad afecta la adherencia de estas, motivos por el cual estas interacciones deben ser estudiadas a mayor detalle.
Addressing Discrimination and Violence against Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ) persons from Brazil: A mobile Health intervention
Authors: Malta Monica , Silva Angelica Baptista , Silva Cosme Marcelo Furtado , LeGrand Sara , Seixas Michele , Benevides Bruna , Kalume Clarisse , Whetten Kathryn
Published: March 2023

Background
Sexual and gender minorities (SGM) experience higher rates of discrimination and violence when compared to cis, heterosexual peers. However, violent crimes and other hate incidents against SGM persons are consistently not reported and prosecuted because of chronic distrust between the SGM community and police. Brazil is one of the most dangerous countries for SGM persons in the world. Herein we describe the development of a mobile health intervention to address the rampant violence against this population, the Rainbow Resistance - Dandarah app.
Methods
We conducted community-based participatory research (CBPR) between 2019-2020. The study started with in-depth interviews (IDIs) and focus group discussions (FGDs) with representatives of the SGM community from Brazil. Descriptive qualitative data analysis included the plotting of a ‘word cloud’, to visually represent word frequency, data coding and analysis of more frequent themes related to app acceptability, usability, and feasibility. A sub-sample of SGM tested the app and suggested improvements, and the final version was launched in December 2019.
Results
Since the app was launched in December 2019, the app recorded 4,114 active SGM users. Most participants are cisgender men (50.9%), self-identified as gay (43.5%), White (47.3%), and aged 29 or less (60.9%). FGDs and IDIs participants discussed the importance of the app in the context of widespread violence toward SGM persons. Study participants perceived this mHealth strategy as an important, effective, and accessible strategy for SGM surviving violence. The CBPR design was highlighted as a key strategy that allowed SGM persons to collaborate in the design of this intervention actively. Some users reported how the panic button saved their lives during violent attacks.
Conclusions
Rainbow Resistance - Dandarah app was endorsed as a powerful tool for enhancing reporting episodes of violence/discrimination against SGM persons and a key strategy to connect users with a safe network of supportive services. Results indicate that the app is an engaging, acceptable, and potentially effective mHealth intervention. Participants reported many advantages of using it, such as being able to report harassment and violence, connect with a safe network and receive immediate support.
A combined clinical and specific genes’ model to predict live birth for in vitro fertilization and embryo transfer patients
Authors: Meng Shihui , Shi Cheng , Jia Yingying , Fu Min , Zhang Tianzhen , Wu Na , Han Hongjing , Shen Huan
Published: March 2023

Background: We aimed to develop an accurate model to predict live birth for patients receiving in vitro fertilization and embryo transfer (IVF-ET) treatment.
Methods: This is a prospective nested case-control study. Women aged between 18 and 38 years, whose body mass index (BMI) were between the range of 18.5–24 kg/m2, who had an endometrium of ≥8 mm at the thickest were enrolled. All patients received IVF-ET treatment and were followed up until they had reproductive outcomes. Endometrial samples during the window of implantation (LH+ 6 to 9 days) were subjected to analyze specific endometrial receptivity genes’ expression using real-time PCR (RT-PCR). Patients were divided into live birth group and non-live birth group based on IVF-ET outcomes. Clinical signatures relevant to live birth were collected, analyzed, and used to establish a predictive model for live birth by univariate analysis (clinical model). Specific endometrial receptivity genes’ expression was analyzed, selected, and used to construct a predictive model for live birth by The Least Absolute Shrinkage and Selection Operator (LASSO) analysis (gene model). Finally, significant clinical factors and genes were used to construct a combined model for predicting live birth using multivariate logistical regression (combined model). Different models’ Area Under Curve (AUC) were compared to identify the most predictive model.
Results: Thirty-nine patients were enrolled in the study, twenty-four patients had live births, fifteen did not. In univariate analysis, the odds of live birth for women with ovulation dysfunction was 4 times higher than that for women with other IVF-ET indications (OR=4.0, 95% CI: 1.125−8.910, P=0.018). Age, body mass index, duration of infertility, primary infertility, repeated implantation failure, antral follicle counting, ovarian sensitivity index, anti-Mullerian hormone, controlled ovarian hyperstimulation protocol and duration, total dose of FSH/hMG, number of oocytes retrieved, regiment of endometrial preparation, endometrium thickness before embryo transfer, type of embryo transferred were not associated with live birth (P>0.05). Only ovulation dysfunction was used to construct the clinical model and its AUC was 0.688. In lasso analysis, GAST, GPX3, THBS2 were found to promote the risk of live birth. AUCs for GAST, GPX3, THBS2 reached to 0.736, 0.672, and 0.678, respectively. The gene model was established based on these three genes and its AUC was 0.772. Ovulation dysfunction, GAST, GPX3, and THBS2 were finally used to construct the combined model, reaching the highest AUC (AUC=0.842).
Conclusions: Compared to the single model, the combined clinical (Ovulation dysfunction) and specific genes’(GAST, GPX3, THBS2) model was more accurate to predict live birth for IVF-ET patients.
CO2 over a coastal urban location and its forcing
Authors: Nair Sandhya K , MS MADHUSOODANAN
Published: March 2023

Recognizing the role of Carbon dioxide (CO2) in altering climate research and air pollution, direct measurements carried out over a coastal urban station using Li-COR CO2/H2O analyser. The objective of the present study is to examine CO2 variability during December-March. Day-to-day variability of CO2 ranges from 380-550 ppm with a mean (423.1) and standard deviation (29.2). Monthly mean diurnal variability of CO2 is maximum during midnight to early morning hours and minimum during afternoon. Overall diurnal variation is similar during the entire months. The link between CO2 concentrations with Wind speed (WS), Atmospheric temperature (T) is examined. Wind speed varies inversely with CO2. Atmospheric temperature shows an exponentially decaying relation with CO2. The diurnal CO2 variability is associated with the competing source/sink mechanisms. The CO2 forcing is estimated and varies from 0.75 to 3.5 Wm-2 with temperature change from 0.75 to 2.00C.
The Impact of government expenditure on economic growth: A Study of SAARC countries
Authors: Rahman Md Arafat
Published: March 2023

In this research study, the main goal is to determine whether government expenditure has impact on economic growth in the SAARC countries. Therefore, the primary goal is to determine whether government expenditure leads to economic development in SAARC countries and vice versa and whether a long-run equilibrium is a significant relationship between the two variables. The study relied solely on secondary data for its findings. Using quantitative techniques such as regression, co-integration and granger causality in the perspective of panel data from SAARC countries including Bangladesh, India, Pakistan, Sri Lanka, and Bhutan from 2011 to 2020, the authors developed their findings in the context of the SAARC countries. To conduct the regression analysis, the Eviews software was employed. Data Were obtained from the United Nations Conference on Trade and Development (UNCTAD), the Ministry of Finance websites of selected nations, macroeconomic trends, the World Bank, and Bangladesh Bank. The random-effects panel OLS model was used to generate the results. As with the preceding methodology, the study discovered an intriguing outcome. First and foremost, Government spending has a strong positive impact on GDP in SAARC countries, according to the empirical data. Second, in SAARC countries, government expenditure and economic growth has a long lasting relationship. In SAARC countries, there is unidirectional causality between GDP and government expenditure in the region . As a result, the study has been validated in that it is consistent with the Keynesian theory as well as Wagner's Law. Over this, SAARC countries should boost their government by being involved in Spurring economic development. However, suppose government spending does not correspond to the needs of the economy. In that case, it may have a significant negative impact on the economy of a country, resulting in society carrying the burden of the consequences.
Assessment of Pyrethroid Insecticides Susceptibility Profiles and Molecular Evaluation of L1014F kdr mutant alleles in Populations of Culex quinquefasciatus from Lymphatic Filariasis Endemic Communities in Akwa Ibom State, Nigeria
Authors: Okafor Martina Anurika , Ekpo Ndifreke Daniel , Opara Kenneth Nnamdi , Udoidung Nsima Ibanga , Alkazmi Luay , Yaro Clement Ameh , Batiha Gaber El-Saber
Published: March 2023

Background: This study investigated the dynamics in pyrethriod resistance and the presence/frequencies of L1014F knockdown resistance mutant allelles in Culex quinquefasciatus vector populations from Uruan Local Government Area of Akwa Ibom State, Nigeria.
Methods: Centre for Disease Control (CDC) bioassay was used to evaluate resistance to permethrin, deltamethrin and alphacypermethrin insecticides following standard protocols. Allele-Specific Polymerase Chain Reaction (AS-PCR) was used in detecting target site insensitivity in the vector populations.
Results: Results obtained revealed that vectors from all the study sites were resistant to permethrin insecticide (mortality rate: 18% - 23%). Suspected resistance (mortality rate: 90% - 93%) to deltamethrin and low resistance (mortality rate: 82% - 85%) to alphacypermethrin insecticides were detected. knockdown was more rapid with deltamethrin and alphacypermethrin than with permethrin across the study sites considering their KDT50 and KDT95. The frequency of the resistant phenotypes ranged between 35.14 % to 55.3 % across the study sites with a net of 45.1 % resistant phenotype recorded in this study. The 1014F allelic frequency calculated from Hardy-Weinberg principle for vector populations across the study sites ranged from 0.5 (50 %) to 0.7763 (77.63 %). All populations witnessed significant (p < 0.05) deviations from Hardy-Weinberg equilibrium in the distribution of these alleles.
Conclusion: The findings of this study show that there is a tendency to record an entire population of resistant vectors in this study area over time due to natural selection.
How does digital finance affect green technology innovation in the polluting industry? Based on the serial two-mediator model of financing constraints and Research and Development (R&D) investments
Authors: Li Jianwei , Zhang Guoxin , Ned John Patrick , sui lu
Published: March 2023

This paper evaluates the importance of combining digital finance with conventional finance and information technology (IT) to bring new opportunities for green technology innovation and transformation within polluting industries. This study builds a theoretical framework “digital finance → financing constraints → R&D investment → green technology innovation” to demonstrate the causal mechanism between digital finance and firms’ green innovation by using the serial two-mediator model. The study shows that digital finance could reduce financial constraints and increase R&D investments, thereby improving enterprises' green technology innovation in the long run. One explanation for such results is the heterogeneity analysis that shows the effects of digital finance on green innovation are more apparent in state-owned enterprises and the regions with lower financial development and with higher financial supervision.
Investigation of adsorption-diffusion behaviors of elementary O2, CO2 and N2 in coal particles: Influence from temperature
Authors: Liu Wei , Qi Minghui , Chu Xiangyu , Peng Shiyang , Han Dongyang
Published: March 2023

Adsorption-diffusion behaviors of gases (i.e., O2, CO2 and N2) in coal are directly related to the coal spontaneous combustion (CSC), in which the temperature is the key factor affecting the gas migration process in coal. In this work, isothermal adsorption experiments of O2, CO2 and N2 under different temperatures were carried out on bituminous coal and anthracite coal samples at 0.5 MPa, respectively. Based on the free gas density gradient diffusion (FDGD) model, the microchannel diffusion coefficients of different gases at different temperatures were calculated, and the effects from temperature were quantitatively evaluated. The results acquired from the experiment and simulation show that (i) the adsorption capacity of these three gases decreases as the temperature increases, and the adsorption capacity at the same temperature satisfies CO2 > O2 > N2; (ii) the FDGD model is verified to be still applicable at high temperatures, indicating that the adsorption-diffusion behavior of O2, CO2 and N2 in coal particles at different temperatures is still consistent with the free gas density gradient diffusion; (iii) the microchannel diffusion coefficient Km of the three gases gradually increases when the temperature goes up. The present work contributes to the understanding of the gases migration process in the development of CSC.
Clinical perspectives and outcomes of Culture-Negative Microbial keratitis: A Retrospective study
Authors: Venugopal Anitha , Andhare Pooja , Rao Anusha , Uduman Mohammed Sithiq , Rameshkumar G
Published: March 2023

Objectives:
To study the risk factors, clinical features, and treatment outcomes of patients with culture-negative keratitis (CNK).
Methods:
A total of 2347 patients of microbial keratitis, excluding clinically viral keratitis, were registered during the study period from January 2018 to December 2020. Out of this, a retrospective review of 933 patients' data with culture-negative keratitis was performed. The variables such as the history of injury, visual acuity, slit-lamp findings with measurements of size and depth of ulcer, microbiological evaluation, duct patency, blood glucose levels, and treatment were considered, and clinical outcome was analyzed.
Results:
Of the 933 patients with CNK, 763 (81.8%) were medically managed, with a mean treatment duration of 2.08 ± 1.7 weeks. Among them, 622 (66.7%) were both smear and culture negative, and 311 (33.3%) showed only smear positivity. Smear was positive for fungus in 23.8% of the patients with a history of trauma (P < 0.001) compared to those without trauma (8.3%). Also, higher incidence of fungal growth on repeat culture was noted. In 22.9% of the patients with a history of trauma, the infiltrate size was > 5mm compared to those without trauma (13.3%).
Conclusion:
The risk factors identified were trauma and the use of previous ocular medications. The culture-negative keratitis can be successfully managed with medications alone if repeat cultures are performed appropriately, empirical therapy includes broad-spectrum antibiotics and antifungals, and knowledge on clinical differentiation of infective keratitis.
Secondary analysis of Huangkui capsule in the treatment of IgAN
Authors: Xing Zenghui , Han Bing , Zhang Yixuan , Li Sichen , Liu Chao , Wang Yiqin , Lin Hongli , Ni Zhaohui , Zhan Yongli , Cai Guangyan , Chen Qinkai , Wang Xiaoqin , Zhang Peiqing , Li Peng , Wang Niansong , Miao Lining , Wang Yong , Chen Xiangmei , Sun Xuefeng
Published: March 2023

Background: IgA nephropathy is the most common primary glomerular disease and an important cause of chronic kidney disease. Previous clinical studies have confirmed that Huangkui capsule could reduce urine protein of IgA nephropathy by 100 mg/d losartan potassium. However,the effect of Huangkui capsule on IgA nephropathy is not clear.
Methods: Based on two multicenter, large sample phase IV clinical trials (NCT 02231125; NCT 02231138), eligible IgA nephropathy patients were screened and the related data were extracted for secondary analysis. Patients were grouped according to the baseline urinary protein, glomerular filtration rate, or pathologic characteristics using IgA nephropathy Oxford classification and the curative effect was analyzed. Taking the decrease of urine protein ≥30% after Huangkui capsule 6-month treatment as the effective standard, multiple regression analysis was used to analyze the influencing factors of Huangkui capsule in reducing urinary protein in IgA nephropathy patients.
Results: 503 patients with IgA nephropathy were enrolled. The efficacy of Huangkui capsule in reducing urinary protein in patients with baseline 24h urinary protein ≥1.0 g/d or glomerular filtration rate ≥60 ml/min reach the effective standard. 24h baseline urinary protein, body mass index, serum albumin, and serum creatinine were the independent influencing factors of Huangkui capsule in reducing urinary protein, but there was no significant correlation with the baseline pathological characteristics. After 6 months of Huangkui capsule treatment, the decrease rate of urine protein increased by 7.9% for every 100mg increase of 24h urinary protein and 6.7% for every 1g/L increase of ALB, while decreased by 1.1% and 7% respectively, for every 1μmmol/L increase of serum creatinine and 1kg/m2 increase of body mass index.
Conclusion: The effect of Huangkui capsule is influenced by basic urinary protein, body mass index, serum albumin, and serum creatinine in IgA nephropathy patients. Huangkui capsule can effectively reduce urinary protein in patients with baseline urinary protein ≥1.0 g/d or glomerular filtration rate ≥60 ml/min.
Health Risk Assessment and Statistical modeling of Toxic Metals in Groundwater of Lahore, Pakistan
Authors: Khalid Iqra
Published: March 2023

The Groundwater of Lahore is now in great concern due to heavy metal pollution. That's why; carcinogenic and non-carcinogenic health risk assessment of the consumption of groundwater is currently needed. The objective of this research is to determine the heavy metals concentration in groundwater and to evaluate its potential health risks for the lifetime of exposure for residents using the USEPA model and probabilistic technique (Monte Carlo Simulation). The groundwater samples were collected from selected sampling sites of the study area and analyzed for physicochemical parameters, and heavy metals. Descriptive statistics showed that the mean concentration of Pb (0.77), Cr (1.828), and Ni (0.35) were higher than PEQS standards for drinking water while values of other parameters were within guidelines. The results of Descriptive statistics and Box Whisker plots showed most of the data showed an un-symmetrical distribution of the parameters. Pearson Correlation matrix showed that heavy metals correlate with physicochemical parameters. ANOVA results also supported the Pearson correlation matrix. The findings of PCA and CA identified the possible sources of pollution, i. e. Industrial discharges, landfill leachates, sewage effluent discharges, and leakage from sewers. EF was calculated with a reference metal i.e. Ca and the trend observed was Pb>Cr>Ni>Mg>As>Zn. Based on the total hazard quotient (HQing + HQder) the trend of heavy metals was found Cr>Pb>As>Ni>Zn for children, adult males, and adult females. The hazard index values (upto 79.12), (75.25), and (59.42) were calculated for children, adult males and, adult females respectively which showed high probability of non-carcinogenic risks. The hazard quotient (HQs) values for children (upto 57.89), for adult males (upto 55.18) and adult females (upto 45) were greater one (>1) for Cr, Pb, Ni and As, which indicates a significant non-cancer risk. Similarly, the cancer risk trend observed was of the order of Cr>Ni>As>Pb. While the cancer risk assessment has shown that 25 people could have carcinogenic effects of each 100 population. By Monte carlo simulation, the Cancer risk trend observed was Cr>Ni>As>Pb for all age groups. The total hazard quotient trend observed was Cr>Pb>As>Ni>Zn which suggested that Cr has high probability of health risks in this study area.
Plant Litter Diversity Disentangles Patterns of Soil Bacterial and Fungal Communities: Evidence from Leaf Litter Decomposition in Citrus Orchards
Authors: quanchao zeng , Chen Zhe , Tan Wenfeng
Published: March 2023

Purpose Plant litter is the main source of soil organic matter, regulating soil microbial community diversity and structure. However, the effects of plant litter traits on soil fungal and bacterial community diversity are still unknown in highly intensive citrus orchards, which represent a special ecosystem that combines the characteristics of farmlands (high input of chemical fertilizers) and natural forests (no tillage and perennial plants).
Methods A microcosm experiment was conducted to assess the effects of citrus leaves (C), alfalfa leaves (A), and the mixture of citrus and alfalfa leaves (CA) on soil bacterial and fungal diversity and community structure in citrus soils. High-throughput sequencing was used to investigate the varied patterns of soil microbial community during the leaf litter decomposition process.
Results Plant litter addition enhanced soil fungal diversity and increased bacterial diversity in the C and A treatments. Alfalfa litter significantly increased soil fungal diversity, but had no significant effect on bacterial diversity. Citrus leaves decreased soil bacterial diversity, and the mixture (CA) caused an increase in bacterial and fungal diversity when compared to the control (CK). Litter addition also significantly changed soil bacterial and fungal community structure, with changes in fungal community structure being more obvious than those in bacterial community structure. Litter addition mainly changed rare bacteria and fungi with lower relative abundance, while abundant bacteria and fungi showed no obvious changes in response to plant litter decomposition.
Conclusions This study highlights that soil microbial diversity is sensitive to plant litter diversity, and different litter traits result in different patterns of bacterial and fungal diversity and community structure in orchards. These results suggest that citrus-derived volatile organic compounds (VOCs) have negative effects on bacterial diversity, and alfalfa leaves improve fungal diversity. The mixture of C and A plays positive roles in both bacterial and fungal diversity. Rare microbes show the most response to leaf litter decomposition, which might play important roles in maintaining soil fertility and health.
Dimensional synthesis of rack-and-pinion steering mechanism using a novel synthesis equation
Authors: Romero Neider , Vieira Rodrigo , Martins Daniel , Romero Anderson
Published: March 2023

This article presents a method for the dimensional synthesis of the rack-and-pinion steering mechanism by optimization technique based on a novel synthesis equation. The proposed kinematic model allows obtaining a polynomial synthesis equation to formulate the objective function as a sum of squares. Then, the computation of the objective function derivatives is straightforward compared to existing formulations. Finally, the application of the proposed method is shown through a numerical example implemented in Matlab®.