bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable agriwaste management at farm level through self-reliant farming system
Authors: Rautaray Sachin Kanta , Dubey Rachana , Raychaudhuri Sachidulal , Pradhan Sanatan , Mohanty Sheelabhadra , Mohanty Rajeeb Kumar , Ambast Sunil Kumar
Published: April 2020

Annually 500 M t organic wastes are produced in India from the agriculture sector. Transportation of bulky organic manures for centralized collection, processing and distribution to farms is cost prohibitive. Hence, recycling of agricultural wastes using vermicompost technology at the farm level is a practical way of managing agriwaste for meeting the plant nutrient requirement. Our experience with a 1.584 ha farm for three years (2015–2016 to 2017–2018) revealed that 8.1 t vermicompost was produced in three batches from 24 t agriwastes produced within the farm area. The system productivity by recycling these farm generated agriwastes and run-off water was 18.05 t (≈11.4 t ha−1) rice equivalent yield which was higher by 2.6 times as compared to rice fallow (4.46 t ha−1). Also, the net return from this system (Indian rupees 70141 ha−1) was higher by 2.3 times, after considering the fixed cost towards construction of a water recycling pond. An increase in carbon stock in soil for the four years study period was 0.66 Mg ha−1 year−1 with the agriwaste recycling system under organic nutrition. For the inorganic fertilizer plot, the increase in carbon stock was 0.53 Mg ha−1 year−1. A decrease in bulk density from 1.56 to 1.46 Mg m−3, increase in water holding capacity from 0.43 to 0.52 cm3 cm−3 and increase in available P and K content in soil from 38.0 and 174.7 kg ha−1 to 45.8 and 186.5 kg ha−1, respectively, were noted. Thus, recycling of agricultural waste at the farm level is useful in improving soil health and crop productivity.
Negative Third-Party Reactions to Male and Female Victims of Rape: The Influence of Harm and Normativity Concerns
Authors: Mulder Eva , Bohner Gerd
Published: April 2020

Male and female victims of sexual violence frequently experience secondary victimization in the form of victim blame and other negative reactions by their social surroundings. However, it remains unclear whether these negative reactions differ from each other, and what mechanisms underlie negative reactions toward victims. In one laboratory study ( N = 132) and one online study ( N = 421), the authors assessed participants’ reactions to male and female victims, and whether different (moral) concerns underlay these reactions. The reactions addressed included positive and negative emotions, behavioral and characterological blame, explicit and implicit derogation, and two measures of distancing. It was hypothesized that male victimization would evoke different types of (negative) reactions compared with female victimization, and that normative concerns would predict a greater proportion of the variance of reactions to male victims than female victims. Multivariate analyses of variance (MANOVAs) were conducted to test whether reactions to male and female (non-)victims differed. Multiple regression analyses were conducted to test the influence of gender traditionality, homonegativity, as well as binding and individualizing moral values on participants’ reactions. Results revealed that participants consistently reacted more negatively to victims than to nonvictims, and more so to male than to female targets. Binding values were a regular predictor of negative reactions to victims, whereas they predicted positive reactions to nonvictims. The hypothesis that different mechanisms underlie reactions to male versus female victims was not supported. The discussion addresses implications of this research for interventions targeting secondary victimization and for future research investigating social reactions to victims of sexual violence. It also addresses limitations of the current research and considerations of diversity.
Postnatal distribution of ZnO nanoparticles to the breast milk through oral route and their risk assessment for breastfed rat offsprings
Authors: Hussain A , Kumar S , Kaul G
Published: April 2020

Various studies in rodents have shown that nanoparticles are transferred to the breast milk. Under the present study, lactating Wistar rats were repetitively gavaged 5, 25, and 50 mg/kg bw of zinc oxide nanoparticles (ZnO-NPs) and 50 mg kg−1 bw of bulk zinc oxide (bZnO) for 19 days after parturition. The results showed that ZnO-NPs were absorbed in the small intestine of dams and distributed to the liver. Furthermore, ZnO-NPs were distributed to the intestine and liver of rat pups through dam’s milk. No significant change in body weight was observed in the dams treated with ZnO-NPs or bZnO and their offsprings as compared to the control group. The spleen weight significantly increased in the rat dams treated with 50 mg kg−1 of ZnO-NPs. ZnO-NPs were mostly excreted through feces. The levels of liver cytochrome P450 reductase and serum total antioxidant capacity significantly decreased in the rat dams treated with ZnO-NPs (50 mg kg−1) and their offsprings. The levels of serum cytokines (tumor necrosis factor-alpha and interleukin-1 beta) and liver injury marker enzymes (alanine aminotransferase and aspartate aminotransferase) significantly increased in the rat dams treated with ZnO-NPs (25 and 50 mg kg−1) and their offsprings. The level of immunoglobulin A secretion in the intestinal fluid of rat dams and their offsprings is significantly increased by increasing the dose of ZnO-NPs. Histopathology of intestine and liver of offsprings whose rat dams were treated with ZnO-NPs (50 mg kg−1) showed gross pathological changes. These results provide information for the safety evaluation of ZnO-NPs use during lactation. In conclusion, a dose-dependent postnatal transfer of ZnO-NPs is hazardous to the breastfed offsprings.
Baltic labour in the crucible of capitalist exploitation: Reassessing ‘post-communist’ transformation
Authors: Bieler Andreas , Salyga Jokubas
Published: April 2020

Thirty years after the fall of the Berlin Wall, this article re-assesses ‘post-communist’ transformation in the Baltic countries from the perspective of labour. The argument is based on a historical materialist approach focusing on the social relations of production as a starting point. It is contended that the uneven and combined unfolding of ‘post-communist’ transformation has subjected Baltic labour to doubly constituted exploitation processes. First, workers in Estonia, Latvia and Lithuania have suffered from extreme neoliberal restructuring of economic and employment relations at home. Second, migrant workers from Central and Eastern Europe in general, trying to escape exploitation at home, have faced another set of exploitative dynamics in host countries in Western Europe such as the UK. Nevertheless, workers have continued to challenge exploitation in Central and Eastern Europe and also in Western Europe, and have been active in extending networks of transnational solidarity across the continent.
Allergic Disease, Short Sleep Duration, and Suicidal Ideation and Plans Among Korean Adolescents
Authors: Kim Ji-Su , Seo Yeji
Published: April 2020

The purpose of the study is to identify the relationships between allergic disease, suicidal ideation, and plans among Korean adolescents. Additionally, we examined the mediating role of short sleep duration. We analyzed nationally representative cross-sectional data from the 12th to 14th Korea Youth Risk Behavior Web-Based Survey; the final sample included 164,725 middle school–aged and high school–aged adolescents (mean age = 15.17 years, standard deviation = .13; 51.1% male). Allergic disease was a statistically significant risk factor for suicidal ideation (crude odds ratio [COR] = 1.284, 95% confidence interval [CI] = [1.246, 1.323]) and suicide plans (COR = 1.165, 95% CI = [1.108, 1.224]). Short sleep duration was a statistically significant mediator ( p < .001). We advised school nurses to assess warning signs of poor sleep—including irritability, depression, sleep problems, poor concentration, and poor academic achievement—and that programs be created to improve sleep and mental health in adolescents with allergic disease.
Modified crow search algorithm–based fuzzy control of adjacent buildings connected by magnetorheological dampers considering soil–structure interaction
Authors: Lin Xiufang , Chen Shumei , Lin Weiqing
Published: April 2020

Finding effective means of protecting structures from dynamic hazards is a challenging task and has gained increasing significance. As for the seismically excited adjacent structures, an intelligent control strategy using magnetorheological dampers as connection devices considering soil–structure interaction is presented. First, the calculation model for the coupled structure–soil–structure interaction–magnetorheological damper system is developed, and the motion equation for calculating the seismic responses is then derived. Second, a semiactive control strategy integrating a modified crow search algorithm into a fuzzy logic control is proposed. In this strategy, to accurately calculate the voltage of magnetorheological dampers, the modified crow search algorithm with a hybrid coding strategy, priority selection scheme for target crows, new solution updating method, and guarantee mechanism of the solution feasibility is proposed to design the fuzzy logic control system. The numerical example of 10-story and 20-story coupled buildings demonstrates that soil–structure interaction should be taken into consideration to avoid overestimating the control effect. Besides, the proposed modified crow search algorithm outperforms genetic algorithm in terms of accuracy and robustness. Furthermore, by using magnetorheological dampers to interconnect the coupled structure with soil–structure interaction, dual advantages, that is response reduction and pounding mitigation can be achieved. The proposed modified crow search algorithm–fuzzy logic control method shows comprehensive performance superiority over its competitors, that is passive-off, passive-on, on–off, linear quadratic regulator–clipped voltage law, and linear quadratic Gaussian–clipped voltage law control strategies.
Quantitative measurements with optical coherence tomography angiography in Behçet uveitis
Authors: Eser-Ozturk Hilal , Ismayilova Leman , Yucel Ozlem Eski , Sullu Yuksel
Published: April 2020

Purpose

The aim of this study was to evaluate the quantitative measurements obtained by optical coherence tomography angiography in patients with Behçet uveitis.

Methods

A total of 22 consecutive patients with Behçet uveitis and 19 age-matched healthy individuals were included in the study. Quantitative analysis of optical coherence tomography angiography images was performed. Comparisons between the patients and the control groups and correlation analysis between optical coherence tomography angiography results and age, visual acuity, duration of uveitis, central macular thickness, and fluorescein angiography scores in the patient group was performed.

Results

The mean superficial foveal avascular zone area was 283.040 ± 113.003 µm2 in the patient group and 254.268 ± 75.813 µm2 in the control group (p = 0.821). The mean deep foveal avascular zone area was 317.657 ± 116.225 µm2 in the patient group and 332.954 ± 94.783 µm2 in the control group (p = 0.775). The foveal avascular zone area could not be calculated in eight eyes with macular atrophy in the patient group because of unclear foveal avascular zone borders. Both superficial and deep capillary vessel density in all regions were lower in the patient group than in the control. Superior, inferior, and temporal capillary vessel density were correlated with fluorescein angiography score (Pearson’s r = –0.380, 0.392, and –0.384, p < 0.05 in superficial plexus; r = –0.357, –0.401, and –0.321, p < 0.05 in deep plexus, respectively). The foveal avascular zone area was correlated with central macular thickness in both superficial and deep plexus (r = –0.387 and –0.331, p < 0.05, respectively).

Conclusion

Recurrent uveitis attacks affecting the macula are associated with a decrease in capillary vessel density and expansion in the foveal avascular zone area in Behçet disease. The qualitative evaluation of the optical coherence tomography angiography findings may be more valuable in patients with macular atrophy.
It is time to implement prepump arterial pressure monitoring during hemodialysis: A retrospective multicenter study
Authors: Sun Chun-Yan , Mo Ya-Wen , Lan Li-Juan , Han Xiao-Wei , Song Li , Zhang Guan-Rong , Zhou Li-Fang , Zheng Shu-Qian , Chen Ying-Gui , Liu Shuang-Xin , Liang Xin-Ling , Fu Xia
Published: April 2020

Introduction:

Prepump arterial pressure (Pa) indicates the ease or difficulty with which the blood pump can draw blood from vascular access (inflow) during hemodialysis. The absolute prepump arterial pressure to blood pump speed (Qb) ratio (|Pa/Qb|) may reflect the dysfunction of other vascular accesses. There is no consensus on the impact of |Pa/Qb| on arteriovenous fistula dysfunction. This study aimed to demonstrate the impact of |Pa/Qb| on arteriovenous fistula dysfunction.

Methods:

In this retrospective analysis, 490 hemodialysis patients with arteriovenous fistula from three hospitals were enrolled. Data were extracted from the I-Diapro database and hospital case systems. The absolute values for |Pa/Qb| and other data collected in the first month of enrollment were used to predict arteriovenous fistula dysfunction and determine the |Pa/Qb| cutoff value. Based on this value, patients were grouped, and 1-year arteriovenous fistula function was analyzed. Patients were followed until arteriovenous fistula dysfunction, until access type replacement, or for 12 months.

Results:

The area under the receiver operating characteristic curve for fistula dysfunction over 1 year was 0.65, with an optimal |Pa/Qb| value, sensitivity, and specificity of 0.499, 60.7%, and 72.6%, respectively. |Pa/Qb| > 0.499 was associated with earlier intervention (317.37 ± 7.68 vs 345.96 ± 3.64 days), lower survival ( p < 0.001), and a 3.26-fold greater risk of arteriovenous fistula dysfunction ( p < 0.001) than |Pa/Qb| ⩽ 0.499.

Conclusions:

|Pa/Qb| was an independent risk factor for arteriovenous fistula dysfunction. Nurses should emphasize |Pa/Qb| monitoring and properly set blood pump speed according to this ratio to protect arteriovenous fistula function. |Pa/Qb| > 0.499 might be a predictive measure of arteriovenous fistula dysfunction.
Comparing electronic monitoring regimes: Length, breadth, depth and weight equals tightness
Authors: Hucklesby Anthea , Beyens Kristel , Boone Miranda
Published: April 2020

This paper compares the use of electronic monitoring in three European jurisdictions – Belgium, England and Wales and the Netherlands. It suggests that rates of use, the accepted method of comparison in relation to imprisonment and a proxy measure of ‘punitiveness’ provide a misleading picture when applied to electronic monitoring. This paper transforms Crewe's concept of ‘tightness’ from a dimension of weight to encompass the overlapping elements of length, breadth, depth and weight to provide a framework for analysing how electronic monitoring regimes are designed to disrupt the lives of monitored individuals. Electronic monitoring regimes are diverse and ‘tightness’ varied as much, if not more, within as between jurisdictions. Comparisons of ‘tightness’ also inverted the scale of ‘punitiveness’ produced using rates of use.
Boys in the Booth: The Impact of Announcer Gender on Audience Demand
Authors: Rogers Ryan
Published: April 2020

This study provides an experiment to examine whether announcer gender impacts audience demand. With special attention to literature detailing the role of women in sports, sports economics, as well as uses and gratifications theory, this study provides an experiment wherein participants watched a sporting event announced by a man or a woman. Afterward, the participants responded to questions regarding their attitudes toward the sporting event they watched. Overall, the male announcer engendered greater feelings of enjoyment and lower feelings of cognitive load than the female announcer. Feelings of autonomy and hostile sexism also played a significant role in mediating the relationship between independent and dependent variables. This study is diagnostic such that it provides empirical evidence that women will have a more difficult time succeeding in this labor market. Also, this study provides noteworthy areas for content producers to focus on in order to increase demand for a product.
Ground-penetrating radar-based underground environmental perception radar for robotic system
Authors: Wu Yuxuan , Shen Feng , Xu Dingjie
Published: April 2020

In recent years, the environmental perception technology for robotic system has attracted a lot of attention from researchers, but only a little of studies on environmental perception technology are focused on the space underground. Meanwhile, in the field of mobile robotic systems, with the development of research on underground emergency hedging and buried targets’ high-resolution fault imaging, more and more attention has also been paid to underground environmental detection and perception. This article proposes a ground-penetrating radar-based underground environmental perception radar (UEPR) for mobile robotic system indoors. The underground environmental perception radar can achieve noncontact and real-time perception, which helps people detect buried targets and get the image of targets more conveniently and precisely. Major contributions of this work are threefold. Firstly, a stepped frequency continuous wave modulation and demodulation scheme is proposed; secondly, a switch device for a six-channel antenna array is designed and contributed; thirdly, based on a linear antenna array and a signal processing platform, the underground environmental perception radar is supposed to achieve three-dimensional imaging in underground space indoors with its low power consumption. For the experiment of three-dimensional imaging on the copper box and underground environment indoors, the process of imaging is successful, although the size of them is a little bigger than the real size. In addition, the comparison experiment shows that the resolution of underground environmental perception radar system is similar with that of sound wave methods, and the working range of underground environmental perception radar system is deeper than the others. It can be concluded that the underground environmental perception radar can detect the copper box underground and perceive something special within 1.5 m depth.
Compensation for absolute positioning error of industrial robot considering the optimized measurement space
Authors: Qi Junde , Chen Bing , Zhang Dinghua
Published: April 2020

Industrial robots are getting widely applied due to their low use-cost and high flexibility. However, the low absolute positioning accuracy limits their expansion in the area of high-precision manufacturing. Aiming to improve the positioning accuracy, a compensation method for the positioning error is put forward in terms of the optimization of the experimental measurement space and accurate modelling of the positioning error. Firstly, the influence of robot kinematic performance on the measurement accuracy is analysed, and a quantitative index describing the performance is adopted. On this basis and combined with the joints motion characteristics, the optimized measurement space in joint space as well as Cartesian space is obtained respectively, which can provide accurate measurement data to the error model. Then the overall model of the positioning error is constructed based on modified Denavit–Hartenberg method, in which the geometric errors and compliance errors are considered comprehensively, and an error decoupling method between them is carried out based on the error-feature analyses. Experiments on the KUKA KR210 robot are carried out finally. The mean absolute positioning accuracy of the robot increases from 1.179 mm to 0.093 mm, which verifies the effectiveness of the compensation methodology in this article.
Visual working memory modulates the temporal resolution of visual perception
Authors: Pan Yi
Published: April 2020

The present study examined how visual working memory affects temporal resolution of visual stimuli that match the memorised nontemporal information about stimulus features (e.g., shapes). The results show that active maintenance of a sample shape in visual working memory impaired the concurrent detection of a sufficiently brief temporal gap within a matching visual target stimulus. The impairment of temporal gap detection was not likely due to the mechanism of visual priming from the presentation of the sample shape, because there was no evidence for priming effects when the sample was only passively viewed without working memory demands or when the sample was initially encoded into memory but did not need to be actively maintained in mind by the time the target stimulus appeared. These findings demonstrate that visual working memory can lower the temporal resolution of visual perception and thereby impair performance in the temporal gap detection task that requires fine temporal segregation of visual information, and they suggest the existence of a previously unknown downside to the interplay between working memory and visual perception.
Risk factors of non-invasive ventilation failure in hematopoietic stem-cell transplantation patients with acute respiratory distress syndrome
Authors: Shen Jiawei , Hu Yan , Zhao Huiying , Xiao Zengli , Zhao Lianze , Du Anqi , An Youzhong
Published: April 2020

Background:

Non-invasive ventilation (NIV) was one of the first-line ventilation supports for hematopoietic stem-cell transplantation (HSCT) patients with acute respiratory distress syndrome (ARDS). Successful NIV may avoid need for intubation. However, the influence NIV failure had on patients’ outcome and its risk factors were hardly known.

Methods:

In this retrospective observational study, we reported risk factors and incidence of NIV failure in HSCT patients who were admitted to the Intensive Care Unit (ICU) with a diagnosis of ARDS and supported with mechanical ventilation, in a 5-year period. Patient outcomes, such as ventilator-free days, ICU-free days, and ICU mortality were also reported.

Results:

Of all the 94 patients included, 70 patients were initially supported with NIV. NIV failure occurred in 44 (63%) patients. Male sex, elevated serum galactomannan (GM) test, (1-3)- β- D-glucan (BG) assay, or elevated serum creatinine level were risk factors for NIV failure. When compared with the NIV success group, failure of NIV was associated with much fewer ICU-free days (22 versus 0, p < 0.001, Cohen’s d = 0.62) and higher ICU mortality (9.5% versus 75.5%, p < 0.001, Pearson’s r = 0.75). There was no difference in ICU-free days, ventilator-free days and ICU mortality between NIV failure and initial invasive mechanical ventilation (IMV) groups. Patients who failed in NIV support had a higher ICU mortality (75.5%) than those who succeeded (9.5%).

Conclusion:

In a small cohort of HSCT patients with mainly moderate severity of ARDS, male patients with elevated serum GM/BG test or serum creatinine level had a higher risk of NIV failure. Both NIV failure and initial IMV groups were characterized by high mortality rate and extremely low ICU-free days and ventilator-free days; failure of NIV support may further aggravate patient prognosis. The reviews of this paper are available via the supplemental material section.
Associated Ophthalmic Injuries in Patients With Fractures of the Midface
Authors: Blumer Michael , Rostetter Claudio , Johner Jean-Pierre , Ebner Julian J. , Wiedemeier Daniel , Rücker Martin , Gander Thomas
Published: April 2020

Purpose:

Concomitant ophthalmic injuries are common in patients with facial fractures, though frequency varies widely in the literature. Major ophthalmic injuries can have drastic consequences for patients, and permanent visual impairment cannot be prevented in all cases. This study analyzed the frequency and distribution pattern of associated ophthalmic injuries in patients who received operative treatment for fractures of the midface.

Material and Methods:

The clinical information system was searched for patients with midface fractures that were treated operatively between December 2014 and November 2017. Demographic, fracture-related, and ophthalmic data were assessed and statistically analyzed.

Results:

This study included 282 patients. The most common fracture types were zygomaticomaxillary complex fractures and orbital floor fractures. Falls and violence were the most common causes of fractures (43.3% and 24.5%, respectively). Chemosis and subconjunctival bleeding were the most common associated eye injuries. The most prevalent long-term eye injury was diplopia, which was identified in 18.4% of cases preoperatively. Postoperative diplopia persisted in 36 cases (12.8%) at 3-month follow-up. Optic neuropathy, enophthalmos, exophthalmos, and retrobulbar hematomas were identified infrequently.

Conclusion:

Minor ophthalmic injuries, including chemosis and subconjunctival bleeding, are more frequently associated with midface trauma. These minor injuries tend to heal quickly and without sequela. Major ophthalmic injuries, including retinal detachment, optic neuropathy, and retrobulbar hematomas, are identified less frequently. Special attention should be paid to patients with diplopia, as this condition may persist and have long-term occupational consequences. Therefore, close interdisciplinary collaboration is essential when treating patients with fractures of the midface to prevent permanent visual impairment.
Prevalence and predictors of chronic pain intensity and disability among adults with sickle cell disease
Authors: Matthie Nadine , Jenerette Coretta , Gibson Ashley , Paul Sudeshna , Higgins Melinda , Krishnamurti Lakshmanan
Published: April 2020

Among 170 adults with sickle cell disease, we evaluated chronic pain impact and disability prevalence, assessed age and gender differences, and identified psychosocial predictors of chronic pain intensity and disability. Most participants had a high level of disability. Chronic pain intensity and disability were significantly associated with pain catastrophizing and chronic pain self-efficacy, and worsened with age. Further research is needed to confirm study findings and develop interventions, including palliative care approaches that address catastrophizing and disability, particularly for young women and middle-aged adults with sickle cell disease. Moreover, consistent clinical assessment of chronic pain and psychosocial health should be implemented.
Corrosion behavior of Ti/Al laminate composites as electrode of chlor-alkali electrolysis
Authors: Wang Lixia , Sun Limin , Cao Yang , Shen Jing
Published: April 2020

High-performance electrodes can solve problems of high voltage and large electricity consumption existing in chlor-alkali industry. A Ti/Al laminate composite (named as Ti/Al-LC) with three-layered structure (Ti/Al3Ti/Ti) is prepared as a new type of anode electrode for chlor-alkali electrolysis. Scanning electron microscope observation shows that the Ti/Al-LC is composited of a thicker inner layer with thickness about 700 µm and two thinner outer layers with thickness about 300 µm. From the X-ray diffraction pattern, it is known that the outer layers consisted of α-Ti and β-Ti phases, while the inner layer consisted of Al3Ti intermetallic phase. A saturated sodium chloride (NaCl) solution at 70°C is purposely chosen as the corrosion electrolyte to analyze the corrosion behavior of Ti/Al-LC as anode electrode for chlor-alkali electrolysis. Electrochemical tests, including potentiodynamic polarization and electrochemical impedance spectroscopy measurements, on a three-electrode system indicate that the Ti/Al-LC has a low corrosion rate with corrosion current density of 1.94 µA cm−2 and stable surface passive film in saturated NaCl solution at 70°C.
How Do Relational Contracting Norms Affect IPD Teamwork Effectiveness? A Social Capital Perspective
Authors: Zhang Lianying , Huang Shanshan , Tian Chenhan , Guo Haiyan
Published: April 2020

As a typical relational contracting (RC) method, integrated project delivery (IPD) attaches importance to key contracting parties’ teamwork effectiveness. This study aims to elucidate the relationship between RC norms and IPD teamwork effectiveness from a social capital (SC) perspective and to examine the moderating role of building information modeling (BIM) application level. Survey data from 144 respondents were analyzed using structural equation modeling. The results show that both cognitive SC (shared vision) and relational SC (trust) partially mediate the relationship between RC norms and IPD teamwork effectiveness and that high-level BIM application strengthens the positive relationships. The findings’ implications are discussed.
CYPminer: an automated cytochrome P450 identification, classification, and data analysis tool for genome data sets across kingdoms
Authors: Kweon Ohgew , Kim Seong-Jae , Kim Jae Hyun , Nho Seong Won , Bae Dongryeoul , Chon Jungwhan , Hart Mark , Baek Dong-Heon , Kim Young-Chang , Wang Wenjun , Kim Sung-Kwan , Sutherland John B. , Cerniglia Carl E.
Published: April 2020

Background

Cytochrome P450 monooxygenases (termed CYPs or P450s) are hemoproteins ubiquitously found across all kingdoms, playing a central role in intracellular metabolism, especially in metabolism of drugs and xenobiotics. The explosive growth of genome sequencing brings a new set of challenges and issues for researchers, such as a systematic investigation of CYPs across all kingdoms in terms of identification, classification, and pan-CYPome analyses. Such investigation requires an automated tool that can handle an enormous amount of sequencing data in a timely manner.

Results

CYPminer was developed in the Python language to facilitate rapid, comprehensive analysis of CYPs from genomes of all kingdoms. CYPminer consists of two procedures i) to generate the Genome-CYP Matrix (GCM) that lists all occurrences of CYPs across the genomes, and ii) to perform analyses and visualization of the GCM, including pan-CYPomes (pan- and core-CYPome), CYP co-occurrence networks, CYP clouds, and genome clustering data. The performance of CYPminer was evaluated with three datasets from fungal and bacterial genome sequences.

Conclusions

CYPminer completes CYP analyses for large-scale genomes from all kingdoms, which allows systematic genome annotation and comparative insights for CYPs. CYPminer also can be extended and adapted easily for broader usage.
High incidence of hepatocellular carcinoma and cirrhotic complications in patients with psychiatric illness: a territory-wide cohort study
Authors: Yip Terry Cheuk-Fung , Wong Grace Lai-Hung , Tse Yee-Kit , Yuen Becky Wing-Yan , Luk Hester Wing-Sum , Lam Marco Ho-Bun , Li Michael Kin-Kong , Loo Ching Kong , Tsang Owen Tak-Yin , Tsang Steven Woon-Choy , Chan Henry Lik-Yuen , Wing Yun-Kwok , Wong Vincent Wai-Sun
Published: April 2020

Background

Because of high-risk behaviours, sedentary lifestyle and side effects of medications, psychiatric patients are at risk of viral hepatitis, alcohol-related liver disease and non-alcoholic fatty liver disease. We aimed to study the incidence of hepatocellular carcinoma (HCC) and cirrhotic complications in psychiatric patients.

Methods

We identified consecutive adult patients in all public hospitals and clinics in Hong Kong with psychiatric diagnoses between year 2003 and 2007 using the Clinical Data Analysis and Reporting System, which represents in-patient and out-patient data of approximately 80% of the 7.4-million local population. The patients were followed for liver-related events (HCC and cirrhotic complications) and deaths until December 2017. Age- and sex-standardized incidence ratio (SIR) of HCC in psychiatric patients to the general population was estimated by Poisson model.

Results

We included 105,763 psychiatric patients without prior liver-related events in the final analysis. During a median (interquartile range) follow-up of 12.4 (11.0–13.7) years, 1461 (1.4%) patients developed liver-related events; 472 (0.4%) patients developed HCC. Compared with the general population, psychiatric patients had increased incidence of HCC (SIR 1.42, 95% confidence interval [CI] 1.28–1.57, P < 0.001). The SIR was highest in patients with drug-induced (SIR 3.18, 95% CI 2.41–4.11, P < 0.001) and alcohol-induced mental disorders (SIR 2.98, 95% CI 2.30–3.81, P < 0.001), but was also increased in patients with psychotic disorders (SIR 1.39, 95% CI 1.16–1.65, P < 0.001) and mood disorders (SIR 1.16, 95% CI 1.00–1.34, P = 0.047). Liver disease was the fifth most common cause of death in this population, accounting for 595 of 10,614 (5.6%) deaths. Importantly, 569 (38.9%) patients were not known to have liver diseases at the time of liver-related events. The median age at HCC diagnosis (61 [range 26–83] years) was older and the median overall survival (8.0 [95% CI 5.0–10.9] months) after HCC diagnosis was shorter in this cohort of psychiatric patients than other reports from Hong Kong.

Conclusions

HCC, cirrhotic complications, and liver-related deaths are common in psychiatric patients, but liver diseases are often undiagnosed. More efforts are needed to identify liver diseases in the psychiatric population so that treatments and screening for HCC and varices can be provided to patients in need.
Efficacy of the quick sequential organ failure assessment for predicting clinical outcomes among community-acquired pneumonia patients presenting in the emergency department
Authors: Zhang Xiangqun , Liu Bo , Liu Yugeng , Ma Lijuan , Zeng Hong
Published: April 2020

Background

The study aimed to investigate the predictive value of the quick sequential organ failure assessment (qSOFA) for clinical outcomes in emergency patients with community-acquired pneumonia (CAP).

Methods

A total of 742 CAP cases from the emergency department (ED) were enrolled in this study. The scoring systems including the qSOFA, SOFA and CURB-65 (confusion, urea, respiratory rate, blood pressure and age) were used to predict the prognostic outcomes of CAP in ICU-admission, acute respiratory distress syndrome (ARDS) and 28-day mortality. According to the area under the curve (AUC) of the receiver operating characteristic (ROC) curves, the accuracies of prediction of the scoring systems were analyzed among CAP patients.

Results

The AUC values of the qSOFA, SOFA and CURB-65 scores for ICU-admission among CAP patients were 0.712 (95%CI: 0.678–0.745, P < 0.001), 0.744 (95%CI: 0.711–0.775, P < 0.001) and 0.705 (95%CI: 0.671–0.738, P < 0.001), respectively. For ARDS, the AUC values of the qSOFA, SOFA and CURB-65 scores were 0.730 (95%CI: 0.697–0.762, P < 0.001), 0.724 (95%CI: 0.690–0.756, P < 0.001) and 0.749 (95%CI: 0.716–0.780, P < 0.001), respectively. After 28 days of follow-up, the AUC values of the qSOFA, SOFA and CURB-65 scores for 28-day mortality were 0.602 (95%CI: 0.566–0.638, P < 0.001), 0.587 (95%CI: 0.551–0.623, P < 0.001) and 0.614 (95%CI: 0.577–0.649, P < 0.001) in turn. There were no statistical differences between qSOFA and SOFA scores for predicting ICU-admission (Z = 1.482, P = 0.138), ARDS (Z = 0.321, P = 0.748) and 28-day mortality (Z = 0.573, P = 0.567). Moreover, we found no differences to predict the ICU-admission (Z = 0.370, P = 0.712), ARDS (Z = 0.900, P = 0.368) and 28-day mortality (Z = 0.768, P = 0.442) using qSOFA or CURB-65 scores.

Conclusion

qSOFA was not inferior to SOFA or CURB-65 scores in predicting the ICU-admission, ARDS and 28-day mortality of patients presenting in the ED with CAP.
The effect of location and type of nutrition content claims (NCCs) on healthy food purchase intentions: findings from an experimental study
Authors: Li Shouwei , Liu Ping , Guo Yan
Published: April 2020

Background

Nutrition Content Claims (NCCs) are often used to enhance the appeal of healthy food products. Appropriate horizontal positioning of different NCCs in the consumer’s visual field may help to improve the effect of the claims. This study examines the extent to which NCCs on food packaging are effective depending on where the claims are located on the packaging and the type of claims.

Methods

Guided by the location effect, a 2 (claim type: benefit-seeking vs. risk-avoidance) × 2 (claim location: left vs. right) experiment is conducted to investigate the influence of NCCs located on the left side of the observer’s visual field compared to claims on the right side of the observer’s visual field on purchase intentions when the claim is either benefit-seeking or risk-avoidance. The study was conducted online. A total of 400 participants took part in the experiment. The study obtained valid data from 365 participants (44.11% males). Analyses examined the purchase intentions of food products with different claims located in different locations. Differences were tested using a general linear model, and a level of significance of 0.05 was used.

Results

The authors find that respondents show higher purchase intentions toward foods with risk-avoidance NCCs located on the left and toward foods with benefit-seeking NCCs located on the right side of the package.

Conclusions

The results provide implications and suggestions for improving healthy food packaging and marketing strategies and for public health policy.
LncRNA FEZF1-AS1 promotes non-small lung cancer cell migration and invasion through the up-regulation of NOTCH1 by serving as a sponge of miR-34a
Authors: Huang Shangxiao , Li Chunjun , Huang Jianfeng , Luo Penghui , Mo Dunchang , Wang Hanlei
Published: April 2020

Background

The involvement of lncRNA FEZF1-AS1 has been analyzed in many types of cancers, while its roles in non-small cell lung cancer (NSCLC) remains unclear. We then explored the role of FEZF1-AS1 in NSCLC.

Methods

qPCR and western blot were performed to measure gene expression. FEZF1-AS1, miR-34a, and NOTCH-1 were overexpressed to analyze the relationship between them. Transwell assays were performed to analyze the effects of transfections on cell invasion and migration.

Results

FEZF1-AS1 was up-regulated in NSCLC patients. Increased expression levels of FEZF1-AS1 were observed with the increase in clinical stages. Bioinformatics analysis showed that miR-34a can bind with FEZF1-AS1. In NSCLC tissues, NOTCH-1 and FEZF1-AS1 were positively correlated. In NSCLC cells, over-expression of FEZF1-AS1 resulted in up-regulated expressions of NOTCH-1, while miR-34a over-expression mediated down-regulated expressions of NOTCH-1. In addition, FEZF1-AS1 and miR-34a did not alter each other, while bioinformatics analysis showed that miR-34a can bind FEZF1-AS1. Analysis of cell migration and invasion showed increased cell invasion and migration rates after FEZF1-AS1 and NOTCH-1 over-expression. MiR-34a played the opposite role and reduced the effects of FEZF1-AS1 over-expression.

Conclusions

FEZF1-AS1 promoted NSCLC cell migration and invasion through the up-regulation of NOTCH1 by serving as a sponge of miR-34a.
Co-circulation of multiple reassortant H6 subtype avian influenza viruses in wild birds in eastern China, 2016–2017
Authors: Hu Chuanxia , Li Xiaofang , Zhu Caihui , Zhou Feng , Tang Wangjun , Wu Di , Li Zhihui , Zhou Lichen , Liu Jing , Wei Xiaoman , Cui Jie , Wang Tianhou , He Guimei
Published: April 2020

Background

H6 subtype influenza viruses were prevalent in domestic poultry and wild birds, which also could pose potential threat to humans. However, little is known about the prevalence of H6 subtype viruses in wild birds in eastern China, a crucial stopover or wintering site for migratory wild birds along the East Asian-Australasian Flyway.

Methods

During the routine surveillance in 2016–2017, H6 subtype AIVs positive samples were identified, and the representative strains were selected for further sequence and phylogenetic analysis and the pathogenicity in mice were evaluated.

Results

Among the 30 H6 positive samples, there were at least four subtypes H6N1, H6N2, H6N5 and H6N8 co-circulated in Shanghai, China. Genetic analysis showed the 8 representative isolates shared homology with different AIV sub-lineages isolated from domestic ducks or wild birds in different countries along the East Asian-Australasian flyways, and were classified into 7 new genotypes. The pathogenicity to mice showed that these H6 viruses could replicate efficiently in the lungs without prior adaptation, but could not cause mice death.

Conclusions

Eight novel strains belonged to H6N1, H6N2, H6N5 and H6N8 subtypes were isolated. Phylogenetic analyses revealed multiple origins of internal genes indicative of robust reassortment events and frequent wild birds-poultry interaction encouraging the evolution and emergence of new genotypes. The pathogenicity to mammals should be closely monitored to prevent the emergence of novel pandemic viruses.
Genotype-phenotype correlations of Berardinelli-Seip congenital lipodystrophy and novel candidate genes prediction
Authors: Ren Meng , Shi Jingru , Jia Jinmeng , Guo Yongli , Ni Xin , Shi Tieliu
Published: April 2020

Background

Berardinelli-Seip congenital lipodystrophy (BSCL) is a heterogeneous autosomal recessive disorder characterized by an almost total lack of adipose tissue in the body. Mutations in the AGPAT2, BSCL2, CAV1 and PTRF genes define I-IV subtype of BSLC respectively and clinical data indicate that new causative genes remain to be discovered. Here, we retrieved 341 cases from 60 BSCL-related studies worldwide and aimed to explore genotype-phenotype correlations based on mutations of AGPAT2 and BSCL2 genes from 251 cases. We also inferred new candidate genes for BSCL through protein-protein interaction and phenotype-similarity.

Results

Analysis results show that BSCL type II with earlier age of onset of diabetes mellitus, higher risk to suffer from premature death and mental retardation, is a more severe disorder than BSCL type I, but BSCL type I patients are more likely to have bone cysts. In BSCL type I, females are at higher risk of developing diabetes mellitus and acanthosis nigricans than males, while in BSCL type II, males suffer from diabetes mellitus earlier than females. In addition, some significant correlations among BSCL-related phenotypes were identified. New candidate genes prediction through protein-protein interaction and phenotype-similarity was conducted and we found that CAV3, EBP, SNAP29, HK1, CHRM3, OBSL1 and DNAJC13 genes could be the pathogenic factors for BSCL. Particularly, CAV3 and EBP could be high-priority candidate genes contributing to pathogenesis of BSCL.

Conclusions

Our study largely enhances the current knowledge of phenotypic and genotypic heterogeneity of BSCL and promotes the more comprehensive understanding of pathogenic mechanisms for BSCL.
Correction to: International survey on influenza-associated pulmonary aspergillosis (IAPA) in intensive care units: responses suggest low awareness and potential underdiagnosis outside Europe
Authors: Thevissen Karin , Jacobs Cato , Holtappels Michelle , Toda Mitsuru , Verweij Paul , Wauters Joost
Published: April 2020

In the publication of this article [1], there was an error in Fig. 1 which caused that the a, b were switched and ‘b’ was missing as a caption on Fig. 1b.
Personality-dependent content selection in natural language generation systems
Authors: S. Ramos Ricelli M. , Monteiro Danielle S. , Paraboni Ivandré
Published: April 2020

This paper focuses on the computer side of human-computer interaction through natural language, which is the domain of natural language generation (NLG) studies. From a given (usually non-linguistic) input, NLG systems will in principle generate the same fixed text as an output and in order to attain more natural or human-like interaction will often resort to a wide range of strategies for stylistic variation. Among these, the use of computational models of human personality has emerged as a popular alternative in the field and will be the focus of the present work as well. More specifically, the present study describes two machine learning experiments to establish possible relations between personality and content selection (as opposed to the more well-documented relation between personality and surface realisation), and it is, to the best of our knowledge, the first of its kind to address this issue at both macro and micro planning levels, which may arguably pave the way for the future development of more robust personality-dependent systems of this kind.
Andronov–Hopf and Neimark–Sacker bifurcations in time-delay differential equations and difference equations with applications to models for diseases and animal populations
Authors: Darlai Rachadawan , Moore Elvin J. , Koonprasert Sanoe
Published: April 2020

In many areas, researchers might think that a differential equation model is required, but one might be forced to use an approximate difference equation model if data is only available at discrete points in time. In this paper, a detailed comparison is given of the behavior of continuous and discrete models for two representative time-delay models, namely a model for HIV and an extended logistic growth model. For each model, there are seven different time-delay versions because there are seven different positions to include time delays. For the seven different time-delay versions of each model, proofs are given of necessary and sufficient conditions for the existence and stability of equilibrium points and for the existence of Andronov–Hopf bifurcations in the differential equations and Neimark–Sacker bifurcations in the difference equations. We show that only five of the seven time-delay versions have bifurcations and that all bifurcation versions have supercritical limit cycles with one having a repelling cycle and four having attracting cycles. Numerical simulations are used to illustrate the analytical results and to show that critical times for Neimark–Sacker bifurcations are less than critical times for Andronov–Hopf bifurcations but converge to them as the time step of the discretization tends to zero.
Signature of the 27-day oscillation in the MLT tides and its relation with solar radiation at low latitudes
Authors: Guharay Amitava , Batista Paulo Prado , Buriti Ricardo Arlen , Schuch Nelson Jorge
Published: April 2020

The modulation of the dominant atmospheric tides (i.e. diurnal, semidiurnal and terdiurnal) in the mesosphere and lower thermosphere (MLT) is investigated using long-term meteor wind database from three Southern hemispheric low-latitude locations, São João do Cariri (7.4° S, 36.5° W), Cachoeira Paulista (22.7° S, 45° W) and Santa Maria (29.7° S, 53.7° W). The spectral analysis reveals an evident and intermittent signature of a 27-day oscillation in the tidal amplitudes. Relationship between the 27-day tidal modulation in the MLT and solar rotation is looked into utilizing solar UV flux (Lyman-α) that indicates a conspicuous linkage of the tides with the solar short-term variability. The strong correlation between the solar variability and tidal modulation in the concerned period with positive lags at certain intervals may indicate predominate solar influence on the MLT tides. Potential involvement of the lower, middle and upper atmospheric dynamics and chemistry to support the observed oscillation feature is deemed plausible.