bluuebunny/crossref_metadata_2025 huggingface dataset:
Corn and cassava flours can replace wheat flour in gluten-free fish fingers
Authors: Cavenaghi-Altemio Angela Dulce , Graciano Fonseca Gustavo
Published: June 2024

The aim of this work was to develop and to characterize fish fingers prepared with mechanically separated meat of hybrid surubim, with and without gluten. Four treatments were evaluated by varying the three steps of pre-dusting, battering, and breading. They have included wheat flour (T1), fishmeal (T2), corn flour (T3) or a blend of corn flour and cassava flour (T4). Characterization was carried out in terms of chemical, physical, microbiological, and sensory analyzes. Moisture content of the samples varied from 59.73% (T3) to 61.14% (T1), protein from 10.60% (T3) to 14.25% (T2), crude fiber from 11.00 to 11.42%, lipid from 4.42 (T1) to 10.91% (T2), and ash from 1.96% (T3) to 2.60% (T2). The highest breading yield (27.15%) coincided with the lowest shear strength (5.75 N) for T1. A darker color was observed for T2, which was prepared with fish meal. The average scores of the sensory attributes ranged from 6.12 to 7.50. All treatments presented acceptance indexes above 70%, except for the color attribute of T2. The purchase intentions for “certainly would purchase” and “possibly would purchase” were 82, 64, 72, and 72% for T1, T2, T3, and T4, respectively, with a rejection index ranging from 6 to 14%. It was concluded that treatments with corn flour (T3) and the mixture 1:1 of corn flour and cassava flour (T4) are good alternatives to replace wheat flour (T1), favoring celiac consumers.
The Eocene to Oligocene boundary and paleoclimatic indications based on calcareous nannofossils of Tonasa Formation, South Sulawesi, Indonesia
Authors: Farida Meutia , Jaya Asri , Ahmad Asmita , Nugraha Jimmi
Published: June 2024

The biostratigraphy of the Tonasa Formation in the Jeneponto Regency of South Sulawesi, Indonesia, is still poorly known, and there are barren ages, such as much of the Oligocene to Early Miocene. The Tonasa Formation is well exposed along the coast of the Jeneponto Regency, in which the Karama area consists of the most important outcrops of this formation which in this area consists of interbedded marl and limestone. Our study focuses on the biostratigraphy of the Karama area section A based on nannofossil. Samples were collected by measured stratigraphy methods and then subjected to investigation using smear slides. The assemblages of species were determined by semiquantitative analysis. Data analysis obtained three nannofossil datums (boundaries): The First Occurrence (FO) of Sphenolithus pseudoradians NP19/NP20), the First Occurrence of Sphenolithus distentus (CP.16/CP.17), and the Last Occurrence (LO) Sphenolithus predistentus (NP.23/NP.24. The zonal boundary was determined based on calcareous nannoplankton; the Late Eocene to Middle Oligocene boundary of the Tonasa Formation was found in this section. Interestingly, throughout this period, the marker species in this section is Sphenolithus. In addition, the presence of Sphenolithus, Discoaster, and Zygrhablithus bijugatus indicated that the basin was in warm water condition.
Thromboprophylaxis during pregnancy for prevention of adverse complications in patients with inherited thrombophilia: a literature review
Authors: Kirovakov Zlatko , Gyokova Elitsa , Hinkova Nadezdha , Konova Emiliana
Published: June 2024

Compared with non-pregnant women, pregnancy alone carries a three- to fivefold higher risk of venous thromboembolism (VTE). Despite the increasing use of low-molecular-weight heparin in identified high-risk patients, pulmonary embolism is still the leading cause of maternal mortality. However, evidence for optimal use of thromboprophylaxis is scarce. Thrombophilia (hereditary or acquired) is thought to predispose to both VTE and is also associated with complications of pregnancy, such as recurrent miscarriages and preeclampsia. This review discusses the current evidence for optimal thromboprophylaxis during pregnancy by focusing primarily on VTE prevention strategies, the potential to prevent recurrent complications during pregnancy with low molecular weight heparin (LMWH), aspirin, and Nattokinase in pregnant women with congenital thrombophilia.
Crise et/ou métamorphose ? Prolégomènes
Authors: Missonnier Sylvain
Published: June 2024

Les termes crise et métamorphose sont très fréquemment utilisés en clinique. Leur sens sont parfois distincts ou synonymes. L’objectif de l’auteur est de définir séparément ces termes puis d’en envisager un hypothétique territoire commun afin d’en examiner une mise en perspective clinique. Cette analyse transversale met en exergue trois problématiques en résonance avec la psycho (patho) logie : 1) les crises et/ou métamorphoses sont consubstantielles à la condition humaine, 2) elles commémorent la néoténie humaine, 3) les réponses des sujets et des groupes face à l’incertitude de leurs issues constituent des marqueurs essentiels en clinique. L’auteur s’appuie sur des grands textes de la littérature, des références cinématographiques et des références psychanalytiques pour illustrer son propos.
La violence de la métamorphose
Authors: Charazac Pierre
Published: June 2024

Trois textes de Kafka montrent comment la métamorphose s’inscrit dans un imaginaire violent qui, dans le cas des décès de la Covid-19 au sein des ehpad , a fait passer dans la réalité le fantasme des soignants de donner la mort à leurs résidents. Le désir de métamorphose des institutions psychiatriques ou gériatriques, qui se manifeste notamment par le changement de leur appellation, questionne sur le renforcement de leur déni des aspects négatifs du soin et sur leur rapport avec la mort.
Accompagner le vieillissement, d’hier à aujourd’hui
Authors: Fourques Catherine , Hanon Cécile
Published: June 2024

Le vieillissement de la population, véritable enjeu de santé publique, impose une réorganisation sociétale avec une attention privilégiée envers les problématiques du grand âge. L’évolution de nos représentations sur le vieillissement, questionner les enjeux autour de l’autonomie, la dépendance, la fin de vie, les aménagements psychopathologiques, les intrications avec les maladies somatiques et cognitives… ce sont autant de cheminements de pensée qui sont essentiels pour les soignants auprès des personnes âgées et qui permettent d’ajuster les projets et les dispositifs d’accompagnement et de soins. La psychiatrie de la personne âgée s’est construite autour de ces problématiques et a intégré en son sein des compétences diverses, entrecroisant les champs du sanitaire et du médico-social, alliant l’expertise médicale et psychologique aux apports de l’éthique.
Autour de l'œuvre de Jean-Paul Valabrega
Authors: Dollé-Monglond Brigitte
Published: June 2024

Mon propos est ici de questionner des rapprochements entre deux champs de pensées pourtant dissemblables et engagés dans un registre de savoir résolument spécifique. L’omniprésence de cette préoccupation qui s’articule autour de la question de la causalité ouvre sur un trait distinctif : une aspiration à la totalité aussitôt contrebalancée par la conscience de l’inachèvement du savoir.
Autour de l'œuvre de Jean-Paul Valabrega
Authors: Defrenet Bernard
Published: June 2024

En référence à la singularité des récits des origines dans la pensée grecque préservant cette part de mystère propre au Logos grec, l’anthropologie psychanalytique développée par Jean-Paul Valabrega s’appuie sur une démarche épistémologique qui lutte contre l’éradication des représentations du Temps et réfute la pensée linéaire aristotélicienne, pour réintroduire des modes de causalités plurielles et relativistes. En tenant compte de la spécificité de la méthodologie axiomatique, ce travail se centre sur l’oralité primaire et les mécanismes de dénégation de la mort, sur l’articulation des processus idéiques et ceux relatifs à la constitution de la représentation et de la nomination de la mort, sur les liens entre l’idéalité et la mort à travers la figure du héros. La lecture de la théorie de l’identification, qui date de 1995, est problématisée par les dernières contributions conceptuelles sur les mythes qui proposent une étiologie-eschatologie . Sur le plan ontologique, l’identité est à l’identification, ce que sur le plan mythologique, la permanence est à la métamorphose. Cette lecture est agrémentée de quelques références à l’art contemporain traitant du temps, de l’oralité primaire, d’identité, de la mort.
Autour de l'œuvre de Jean-Paul Valabrega
Authors: Kamieniak Jean-Pierre
Published: June 2024

Qu’il soit fondateur, étiologique ou magico-sexuel, tout mythe – tout complexe phantasmo-mythique – pose inévitablement l’énigme de sa constitution et invite à s’interroger sur la place de l’Autre dans leur transmission, ainsi que le propose cette ouverture.
Psychoalcoologie fondamentale et théorique
Authors: Menecier Pascal , Lefranc Delphine
Published: June 2024

L’alcool est une substance qui est tellement diffusée dans nos sociétés que bien des notions sur ses effets et dommages semblent intuitivement acquises à chacun d’entre nous, même soignant. La connaissance précise des effets et traductions lors de prises aiguës ou chroniques comme lors d’arrêts de consommations est cependant indispensable aux professionnels de santé. Ainsi, la relation de soin peut s’établir sur un minimum de partage théorique, d’empathie et de compréhension mutuelle de ce que vit le patient.
Psychoalcoologie fondamentale et théorique
Authors: Menecier Pascal
Published: June 2024

Si l’alcool est un psychotrope, et les boissons alcoolisées sont principalement consommées pour moduler la pensée (même sous le couvert de la dégustation), le mésusage d’alcool ne peut se résumer à l’autotraitement d’une souffrance psychique préalable, oubliant le potentiel addictogène du produit. Inversement, le mésusage d’alcool s’accompagne de conséquences psychiques, psychopathologiques et d’authentiques souffrances, qui vont au-delà de ce qui a pu être nommé la souffrance alcoolique. Ainsi, la cooccurrence entre troubles psychiatriques et mésusage d’alcool dépasse la coïncidence, ouvrant un espace de réflexion sur la complexité des soins à ce carrefour de la santé.
Psychoalcoologie fondamentale et théorique
Authors: Menecier Pascal
Published: June 2024

L’alcool n’est pas neuroprotecteur : il est essentiellement neurotoxique et délétère sur la cognition. Il induit divers troubles cognitifs (syndromes dysexécutifs et amnésiques), eux-mêmes facteurs de pérennisation des conduites d’alcoolisation. La réversibilité de la plupart des troubles cognitifs liés à l’alcool (TCLA), parfois partielle, souligne l’intérêt de les considérer, de les envisager sans fatalisme, et les intégrer dans les stratégies de soin. Il n’est jamais trop tard pour mieux aller, même avec des troubles de l’usage d’alcool, des troubles cognitifs, le plus souvent lors d’arrêt de consommation d’alcool.
Psychoalcoologie fondamentale et théorique
Authors: Menecier Pascal
Published: June 2024

L’alcool, produit à la fois bon et mauvais, cristallise autour de ses usages diverses formes de dualité et d’ambivalence, qui concernent autant les usagers que les intervenants de soin. Sous tous ses aspects curatifs ou préventifs, le soin en alcoologie peut recourir à des renforçateurs externes de mieux-être (gestion des contingences) ou à des messages menaçants et dissuasifs (appels à la peur), qui coexistent, avec de fréquents mélanges des registres et des incertitudes persistantes sur leur efficience et pertinence. Dans cet ensemble, le professionnel de santé devra ajuster continuellement un positionnement clinique, au minimum bienveillant, sans excès d’emprise sur le soigné ni démission négligente.
Psychoalcoologie fondamentale et théorique
Authors: Menecier Pascal
Published: June 2024

À un moment où l’addictologie considère moins les sevrages que les alternatives de réductions des risques et des dommages, avec en principal support des traitements de substitution, l’alcoologie, premier modèle de description semble échapper à cela. Cependant, entre les proximités de propriétés entre alcool et benzodiazépines, la grande fréquence d’usage et de mésusage associés de ces produits peut laisser une place à leur éventualité d’emploi comme traitement de substitution alcoolique, parmi d’autres substances étudiées dans ce paradigme.
Psychoalcoologie fondamentale et théorique
Authors: Lefranc Delphine , Rotheval Loetitia
Published: June 2024

L’usage ou le mésusage d’alcool concerne aussi les femmes en âge de procréer : d’où l’importance d’une évaluation précoce des modes de consommations, dès l’élaboration d’un projet de grossesse, intégrant le repérage des mésusages. Le poids des représentations divergentes entre grossesse (avec angélisme) et mésusage d’alcool (encore plus diabolisé) est un frein à l’accès aux soins et à l’alliance thérapeutique nécessaire avec les femmes, alors que cette période est propice à l’ouverture vers un travail d’introspection et aux changements.
Psychoalcoologie fondamentale et théorique
Authors: Moscato Alba
Published: June 2024

Des études ont souligné que les problèmes familiaux contribueraient à la poursuite de l’alcoolisation de la personne ou à favoriser sa rechute. Dans l’approche systémique, la dépendance à l’alcool est considérée comme un symptôme du groupe et ses conséquences seraient organisatrices relationnelles de la famille. Elles généreraient des règles implicites qui permettraient la conservation du lien avec l’alcool pour le buveur.
La movilización eclesiástica en defensa de sus haberes: una reacción ante la política religiosa republicana (1931-1934)
Authors: Marcos Del Olmo Maria Concepción
Published: June 2024

Una delle più difficili – e anche sconosciuta – delle battaglie che ingaggiò la chiesa durante il primo biennio repubblicano e fino all’aprile del 1934, fu la legge sui beni del clero che fu approvata dal Parlamento. Tale compito fu assolto da un’apposita commissione di ecclesiastici, i cui membri si rivolsero, in modo individuale e con la dovuta discrezione, ai deputati più influenti del tempo. Questi seppero mobilitare l’insieme delle autorità diocesane affinché si potesse raggiungere, proprio attraverso la loro partecipazione, tutti i delegati eletti nei diversi collegi elettorali.
Conception et usages de ressources didactiques : des ressources disciplinaires classiques à des ressources a-disciplinaires à construire
Authors: Vergnolle-Mainar Christine , Bruguiere Catherine
Published: June 2024

Resources for teaching biology, geology and geography are questioned using innovative approaches supported by collaborative research. The interest of resources not referenced to a discipline is highlighted, into a perspective of disciplinary didactics, an interdisciplinary approach and the training of students as future citizens. This use of a-disciplinary resources is an issue for teacher training.
Entre recherches en didactique et enseignement/formation : transposition ou enrichissement mutuel ?
Authors: Boilevin Jean-Marie , Orange Christian
Published: June 2024

How can we think about the relationship between didactic research and the development of the teaching profession? If the simplistic idea of application, too often retained by decision-makers, is not appropriate, the concept of transposition does not seem relevant either. We propose here a discussion of these relationships from two points of view, each based on a researcher's and trainer's experience. We thus highlight the indispensable diversity of collaborative work between teachers and researchers, corresponding to different research questions and questions arising from practice.
L’astronomie dans la formation des enseignants du premier degré : un contexte interdisciplinaire pour favoriser les enseignements en mathématiques et en sciences
Authors: Abboud Maha , Nechache Assia , Rollinde Emmanuel
Published: June 2024

We examine how to foster a better appreciation of mathematics and science among trainee school teachers in order to improve their engagement in the teaching of scientific disciplines. To this effect, we adopt an approach based on the “polyvalence” of the school teacher. Through a training program based on interdisciplinarity between mathematics and sciences, in the context of astronomy, we study the related professional development in the pathways of two groups of trainee teachers. These two case studies show the importance of mastering scientific knowledge in the implementation of a “polyvalence” that allows two disciplines to enrich each other without excluding each other. This constraint often implies focusing the trainer's intervention on disciplinary knowledge more than on pedagogical and curricular knowledge.
La méthodologie : n’en faire qu’un discours ou bien reconnaître sa nécessité ?
Authors: Ferrière Hervé
Published: June 2024

Pourquoi un historien des sciences lirait-il le travail de Michael Stolleis, historien du droit récemment disparu ? Parce que sa démarche comparatiste, transparente et interdisciplinaire, et sa volonté de mettre en avant des exemples concrets sont déjà de véritables sources d’inspiration. Mais surtout parce que face aux défis incommensurables (écologiques, politiques, juridiques…) se dressant devant nous, le souci de Stolleis pour les questions méthodologiques en fait une source de réflexion quant aux règles historiographiques et aux raisons même de l’activité des historien·nes.
La carrière ou l’emploi ? Le système de la fonction publique d’État en France (1919 - 1950)
Authors: Lohou Quentin
Published: June 2024

L’article présente les enjeux que sous-tendent en France, entre 1919 et 1950, les systèmes de fonction publique aujourd’hui qualifiés « de la carrière » et « de l’emploi ». Ces systèmes répondent à deux interrogations : la fonction publique doit-elle être composée essentiellement d’agents titulaires ou de non-titulaires ? De quels régimes juridiques doivent-ils dépendre ? Selon les réponses, la fonction publique reflète deux conceptions. L’une, démocratique, accorde aux agents la stabilité de l’emploi et les intègre dans une « logique participative ». L’autre, autoritaire, s’y oppose.
Las perlas de Rosa (1914) de Aurora Cáceres: una bella muerte. Imaginarios estético-ideológicos modernistas de entre siglos en clave femenina
Authors: Grau-Lleveria Elena
Published: June 2024

Dentro de la producción modernista femenina, Las perlas de Rosa (1914), de Aurora Cáceres, constituye un texto excepcional porque presenta la crisis existencial de una mujer donde se ponen en juego los lenguajes modernistas masculinos contaminándolos con un discurso de perdón y redención cristianos que, a su vez, alteran la ideología católica femenina hegemónica del momento. Las líneas de análisis crítico que propongo en este artículo abordan la configuración de los lenguajes estético-ideológicos y la estructura narrativa de la novela. Ello me permite analizar, la vida y la crisis vital de la protagonista como una escenificación de la lucha política que Cáceres desarrolló en este texto para proponer una ideología de representación de feminidad distinta a las propuestas por los modernistas, pero dentro de una estética modernista.
María Jesús Alvarado Rivera en Buenos Aires: transnacionalidad, ficción sentimental y cultura masiva para un nuevo feminismo
Authors: Vicens María
Published: June 2024

Este artículo aborda los años de residencia de la escritora peruana María Jesús Alvarado Rivera en la Argentina para analizar cómo impactó la vivencia del exilio en su trayectoria autoral, su modo de concebir la ficción y de interpelar a un público masivo desde una perspectiva popular y feminista. Si bien son escasos los datos recuperados sobre esta etapa de su vida, las obras literarias que enmarcan esa experiencia transnacional trazan diversas filiaciones, tanto con las escritoras peruanas que se habían instalado en la Buenos Aires finisecular, como con el proceso de modernización que atraviesa al campo cultural argentino en la década del veinte, que resignifican esos años de migración en clave literaria.
Les embarras des employeurs : recruter dans des métiers peu qualifiés en tension
Authors: Albandea Ines , David Pauline , Roupnel-Fuentes Manuella , Bernard Pierre-Yves
Published: June 2024

Les tensions de recrutement concernent actuellement de nombreux métiers. Cette recherche s’appuie sur le cadre théorique des conventions et sur des entretiens semi-directifs auprès de chefs d’entreprise ou de responsables ressources humaines (RH). Dans un contexte incertain, les employeurs se réfèrent fréquemment au savoir-être et déclarent privilégier des stratégies de recrutement qui s’apparentent à la « cité domestique », telles que les réseaux de proximité, la confiance ou le modèle familial et hiérarchique. Ils cherchent à se montrer créatifs en empruntant à la « cité inspirée » pour attirer et garder des salariés. Toutefois, ces stratégies demeurent insuffisantes, en particulier pour les métiers peu qualifiés où les conditions de travail sont souvent difficiles et les emplois peu attractifs.
Capacité de reconversion des salariés en emploi peu qualifié : du vouloir au pouvoir
Authors: Stephanus Camille , Vero Josiane
Published: June 2024

À l’heure où les dispositifs publics érigent les reconversions à des fins de « sécurisation des parcours » individuels, d’adaptation aux mutations du travail et de résorption des difficultés de recrutement, nous examinons leur mise en œuvre entre 2015 et 2019. Nous mobilisons le Dispositif d’enquête sur la formation et les itinéraires des salariés (DEFIS). Comment les salariés sont-ils mis en (in)capacité de se déterminer, de se projeter dans l’avenir, de mobiliser des dispositifs publics et d’accomplir leurs souhaits ? Nous analysons les aspirations et parcours, et la manière dont ils se concrétisent et interagissent avec des facteurs externes. Cette approche croisée compare la capacité de reconversion des employés et ouvriers peu qualifiés à celle des salariés moyennement et très qualifiés. Nous proposons une grille d’analyse à partir de la notion de capabilité définie par A. Sen. Ensuite, nous appréhendons la capacité de reconversion selon ces deux dimensions : la liberté de choix et le pouvoir d’agir. Enfin, nous concluons sur les inégales capacités à accomplir une reconversion et les difficultés auxquelles font face ceux qui occupent les métiers peu qualifiés.
Les jeunes en emploi peu qualifié pendant la crise sanitaire : quelles spécificités de leurs trajectoires professionnelles ?
Authors: Robert Alexie , Sawadogo Arthur W. Félix
Published: June 2024

Comment a évolué la situation professionnelle des jeunes en emploi peu qualifié après le début du premier confinement ? Quelles différences par rapport à leurs homologues en emploi plus qualifié ? Ces questions seront examinées sous l’angle de la segmentation du marché du travail à partir de l’enquête Génération 2017 du Céreq, menée en 2020. Les jeunes en début de carrière occupant un emploi peu qualifié au début de la crise apparaissent davantage confrontés à de la mobilité externe, notamment à une sortie de l’emploi vers le chômage, l’inactivité ou la reprise d’études. Cependant, l’écart avec les salariés plus qualifiés ne se creuse pas par rapport à la période qui a précédé la crise ; de même, ils sont aussi nombreux que les autres à connaitre une trajectoire ascendante en cas de mobilité vers un autre emploi portée, surtout pour les plus diplômés, par l’accès à une qualification supérieure dans l’emploi.
L’aspiration à changer de métier, à l’aune de la qualification des jeunes et des emplois
Authors: Paola Vanessa di , Joutard Xavier , Moullet Stéphanie
Published: June 2024

Cet article éclaire la manière dont l’expression d’une aspiration individuelle à changer de métier émerge pour les jeunes les moins qualifié·es (ayant au plus un baccalauréat) en début de parcours et dans quelle mesure cette aspiration pourrait jouer un rôle sur les changements effectifs de métier. À partir de l’enquête Génération 2010 du Céreq à sept ans, on montre qu’elle est importante dès les premières années de vie active, puisqu’elle concerne 40 % de ces jeunes, mais qu’elle ne se transforme en réalisation effective que pour les jeunes les plus doté·es, à la fois scolairement et professionnellement. Les jeunes sans titres scolaires ont une moindre propension à aspirer, et lorsque celle-ci s’exprime, elle ne se réalise que pour celles et ceux déjà en emploi qualifié.
Evaluation of Structural Response in Ultra-High-Strength Concrete and Carbon Fiber Reinforced Frames Exposed to High Temperatures Using Numerical Simulation
Authors: Manco Danitza Liliana , Palacios Anthony L. , Davila Victor I. , Casas Joan R. , Delgadillo Rick M.
Published: June 2024

Reinforced concrete exposed to high temperatures, such as in a fire, poses a serious threat to buildings by weakening the concrete and reducing the structure's stiffness. Therefore, the article investigated the structural behavior of reinforced concrete when subjected to elevated temperatures in Peru, where many structures are not designed to withstand high temperatures, leading to irreparable damages such as loss of human lives and changes in material properties. To enhance the heat resistance of reinforced concrete, carbon fibers were added, and a percentage of ultra-high-strength concrete was incorporated. The material was analyzed using the finite element method. Different frames were evaluated, focusing on the use of matrices and nodes. The proposal involved adding new materials; carbon fibers were added at 0.06%, and ultra-high-strength concrete at 20%. These quantities were chosen based on the researched articles. First, the properties of each material were defined and input into the software. Then, a temperature ranges from 100°C to 1000°C was defined. The results were evaluated, and improvement percentages regarding displacements due to applied loads were determined. The findings indicate a 33.05% improvement in distributed load and temperature-induced loads between 100°C to 1000°C, varying between 17% and 6.56% respectively. It was concluded that higher temperatures result in more significant damages such as changes in color, deflections, and loss of stiffness, increasing the probability of collapse in a shorter time frame. In conclusion, the use of the proposed materials enhances resistance and reduces deflections when subjected to various types of loads.
Methodology for Thermal Analysis of Combustion Engines, Applied to Automobiles
Authors: Auccahuasi Wilver , Urbano Kitty , Flores Edwin , Ovalle Christian , Campos -Sobrino Medalith , Quispe-Peña Humberto , Sobrino-Mesias Julia , Benites Nicanor , Marin-Huapaya Juan , Flores-Castañeda Rosalynn Ornella , Olaya-Cotera Sandro
Published: June 2024

The combustion engines are widely used in the daily life of people, in cars, we find them with greater emphasis, and currently hybrid engines and electric motors are being used. In this analysis, one of the important factors for the failure of combustion engines is the temperature, for which cars have cooling systems, through the use of radiators and coolant-based systems. In this work we present a methodology for the analysis of the state of the components of the combustion engine system in cars, through the use and analysis of thermal images, for which it is necessary to identify the zones or control points depending on the model and type of engine and car, The analysis procedure requires a thermal camera, the results presented are related to the comparison of an optical and thermal image, in order to locate the control point, the method can be applied by mechanics, maintenance personnel and car drivers themselves, to analyze the condition of their car.
Influence of Rice Husk Ash on Self-Compacting Concrete to Avoid the Presence of Honeycombs in Columns
Authors: Boza Rabanal Marcos Jesus , Tarazona Alarcon Alexis Pablo , Lopez Pasapera Karla Lisette
Published: June 2024

In structural columns, honeycombs are very common in small and big works. This problem is caused by poor consolidation of the concrete that increases the probability of honeycombs (voids left in concrete). These imply costs incurred and affect the work schedule. An exhaustive search is carried out regarding methods in the scientific literature and materials with respect to their availability in the market related to the problem. In this way, it was found that the design of a self-compacting concrete using the ACI 237R-07 with the use of a supplementary cementitious material aims to be a solution to this problem. Rice husk ashes contain silicon oxide and aluminates. These elements improve or increase the strength of the concrete, offer workability and fluidity properties. It was found that with a 5% replacement, 735 mm and 730 mm of slump flow and J-ring were obtained, respectively. Additionally, the V-funnel time was 9.58 seconds. The use of RHA positively increased the values of the measured tests with respect to the standard, thereby improving the workability and stability properties.
Methodology for the Analysis of the Operation of High-Performance Computing Equipment
Authors: Auccahuasi Wilver , Urbano Kitty , Flores Edwin , Linares Oscar , Ovalle Christian , Campos -Sobrino Medalith , Quispe-Peña Humberto , Sobrino-Mesias Julia , Benites Nicanor , Marin-Huapaya Juan , Flores-Castañeda Rosalynn Ornella , Olaya-Cotera Sandro
Published: June 2024

High-performance computing equipment uses graphic processors, known as GPUs, as a mechanism for high computational capacity. To increase the computational capacity, additional graphics processors are added in the configurations. This strategy increases the computational capacity as well as considerably increases the temperature generated by the entire system, normally the GPUs have cooling systems, which help to cool as much as they are required, the operating systems have automatic mechanisms to access the GPUs, these functions are activated when it is required to use them, in the event of a need for high computing capacity requirement. In this work we demonstrate a method to analyze the operation of computing equipment when working on high-performance functions, such as video games, which require high computational capacity to be able to play in real time and perform the tasks. Necessary renderings, the method can be applied to other applications that are necessary to ensure the continued operation of the computing equipment.
Modified Model of Prediction of Carbonation Depth Based on CEB-FIP for Concrete with Portland Cement with High Water-Cement Ratios
Authors: Flores Soto Luis Adrian , Velarde Safra Fabio , Torres Pablo Jhoel Peña
Published: June 2024

CO2 levels in the world are constantly increasing and have generated a great impact on reinforced concrete structures causing increased carbonation. The phenomenon of carbonation causes corrosion of the reinforcing steel, therefore, reinforced concrete structures present a high risk of corrosion of its reinforcing steel causing the reduction of the useful life of the structure, or in extreme cases, a demolition must be carried out. The objective of the present study is to propose a prediction model for carbonation depth in pure concretes which are not designed for durability (w/c<0.50), but when they are designed for resistance (w/c>0.55). CEB-FIP model presents the limit of serving only for concrete with w/c<0.50, due to this, the present study proposes a model that will help as a reference to estimate the useful life of structures that are built and designed in cities where they do not are exposed to these durability conditions. The modified model for predicting the carbonation depth based on CEB-FIP in pure concrete with high w/c (0.60 and 0.72) uses the parameters of temperature, relative humidity, CO2 concentration, and water/cement ratio. The objective is to obtain the accuracy of the modified model for predicting the carbonation depth in concrete over the years. For the results, the theoretical data obtained from the modified model was used and a comparison was made with the experimental results obtained from concrete specimens tested inside an accelerated carbonation chamber to find the model's accuracy.
CCL22 Induces the Polarization of Immature Dendritic Cells into Tolerogenic Dendritic Cells in Radiation-Induced Lung Injury through the CCR4–Dectin2–PLC-γ2–NFATC2–Nr4a2–PD-L1 Signaling Pathway
Authors: Liu Benbo , Wang Yilong , Ma Liping , Chen Guo , Yang Zhihua , Zhu Maoxiang
Published: June 2024

Recruitment of immune cells to the injury site plays a pivotal role in the pathology of radiation-associated diseases. In this study, we investigated the impact of the chemokine CCL22 released from alveolar type II epithelial (AT2) cells after irradiation on the recruitment and functional changes of dendritic cells (DCs) in the development of radiation-induced lung injury (RILI). By examining changes in CCL22 protein levels in lung tissue of C57BL/6N mice with RILI, we discovered that ionizing radiation increased CCL22 expression in irradiated alveolar AT2 cells, as did MLE-12 cells after irradiation. A transwell migration assay revealed that CCL22 promoted the migration of CCR4-positive DCs to the injury site, which explained the migration of pulmonary CCR4-positive DCs in RILI mice in vivo. Coculture experiments demonstrated that, consistent with the response of regulatory T cells in the lung tissue of RILI mice, exogenous CCL22-induced DCs promoted regulatory T cell proliferation. Mechanistically, we demonstrated that Dectin2 and Nr4a2 are key targets in the CCL22 signaling pathway, which was confirmed in pulmonary DCs of RILI mice. As a result, CCL22 upregulated the expression of PD-L1, IL-6, and IL-10 in DCs. Consequently, we identified a mechanism in which CCL22 induced DC tolerance through the CCR4–Dectin2–PLC-γ2–NFATC2–Nr4a2–PD-L1 pathway. Collectively, these findings demonstrated that ionizing radiation stimulates the expression of CCL22 in AT2 cells to recruit DCs to the injury site and further polarizes them into a tolerant subgroup of CCL22 DCs to regulate lung immunity, ultimately providing potential therapeutic targets for DC-mediated RILI.
Unveiling Distinctive MRI Characteristics in the Diagnosis of GFAP Astrocytopathy: A Rare Autoimmune Neuroinflammatory Disorder
Authors: Charan Bheru D. , Priya Shikha , Goel Vinay , Chhatarpal Pinky , Jain Savyasachi , Gupta Anu , Garg Ajay
Published: June 2024

Glial fibrillary acidic protein (GFAP) astrocytopathy is a rare autoimmune inflammatory disorder affecting the central nervous system, involving the meninges, brain parenchyma, and spinal cord. The distinctive radiologic feature observed on magnetic resonance imaging (MRI) is characterized by periventricular radial and linear contrast enhancement. This case report details a 45-year-old male who initially exhibited constitutional symptoms, followed by encephalitis, lower limb weakness, and urinary retention. The MRI findings revealed meningoencephalitis with longitudinal extensive myelitis. Notably, the cerebrospinal fluid analysis confirmed the presence of anti-GFAP antibodies.
Evaluation of Clinical Success of Fissure Sealant, Patients’ Preference and Gingival Damage Following Different Isolation Methods in Children: A Randomised Split-mouth Clinical Trial
Authors: Choksi Kaksha B. , Patel Megha C , Bhatt Rohan K , Goyal Saumya , Patel Foram C , Gori Nasrin A
Published: June 2024

Introduction:

Effective tooth isolation is a key factor affecting the retention and, in turn, the clinical success of fissure sealants. Hence, the aim of this study was to evaluate the clinical success of fissure sealants, patients’ preferences and gingival damage following cotton roll isolation, rubber dam isolation and Mr. Thirsty isolation system in children.

Materials and Methods:

In this in vivo, split-mouth randomised clinical trial, participants aged 6–11 years requiring sealants on the first permanent molars were enrolled according to the inclusion and exclusion criteria. Each participant received sealants on three random first permanent molars using three isolation techniques. The method of choosing which tooth to seal using which isolation system was randomly carried out using a computer allocation system. The time required for sealant placement was recorded for each technique. Following sealant placement, participants were given an interview-based questionnaire to evaluate their preference regarding the isolation techniques. The evaluation of clinical success using USPHS criteria was recorded at baseline and followed up for 3, 6 and 9 months. These data were analysed using IBM SPSS version 25 for Windows statistical software. Kruskal–Wallis test was used for intergroup comparison, and for quantitative data between three groups, analyses were done using the Chi-square test with multiple comparison tests. For all statistical analyses, probability levels of P < 0.05 were considered statistically significant and P < 0.001 as highly significant.

Results:

A total of 93 teeth were clinically evaluated at the end of 9 months; of these, significantly higher retention rates were seen in the rubber dam group, where 71% had completely retained sealants and 29% had a partial loss of sealants. The mean chair side times were 1.94 ± 0.31, 3.28 ± 0.32 and 2.44 ± 0.32 for cotton roll, rubber dam and Mr. Thirsty isolation, respectively. Approximately 60% of participants preferred cotton roll isolation over rubber dam and Mr. Thirsty isolation system. (P = 0.02).

Conclusion:

Cotton roll isolation was the most preferred technique; however, sealant retention was reported to be the best using rubber dam isolation. Mr. Thirsty can be used as a viable alternative in patients where cotton rolls and a rubber dam are contraindicated.
Four-dimensional Printing: An Evolution in Making
Authors: Verma Anirudh , Prasad D Krishna
Published: June 2024

There are promising applications of four-dimensional (4D) printing in the medical field. The need is to identify the research status and explore where this new set of technologies effectively can be deployed. Research articles are searched from Scopus by keywords as ‘4D printing’, ‘medical’, ‘dental’ and undertaken a bibliometric analysis of the identified papers. This study states that 4D printing is the latest technology that creates innovation and addresses complex medical problems. The paper briefly describes the 4D printing and details its difference from three-dimensional (3D) printing technology. The paper identified that research is carried out on 4D printing, but decidedly less publication is available in the medical field reporting the application of this technology. The main limitation is that it requires extensive investment and support for transformation. 4D printing is to provide benefits to medical practitioners especially in the areas not covered by 3D printing technologies. 4D printing helps to create a 3D physical object by adding smart material layer by layer through computer-operated computer-aided design data. It adds a dimension of transformation over time where printed products are sensitive to parameters such as temperature, humidity and time. This technology can provide extensive support in the medical field, especially with better and smart medical implants, tools and devices. Now, doctors and researchers can explore with 4D printing technology to provide better service to the patient.
Assessment of Kinematic and Dynamic Characteristics of Shoulder Mechanism
Authors: Asad Mohammad Rehan
Published: June 2024

Introduction:

The thorax, clavicula, scapula and humerus comprise the finite element musculoskeletal model of the shoulder mechanism, which has been used to analyse its kinematic and dynamic behaviour. The study aims to reflect upon the analysis of the kinematic and dynamic behaviour of the shoulder mechanism.

Materials and Methods:

A comprehensive literature search was conducted to identify the relevant literature. Databases such as PubMed, Scopus and Google Scholar were used to search for literature published between 2000 and 2023.

Results:

The scapulothoracic gliding plane’s motion restrictions, which convert the shoulder girdle into a closed-chain mechanism, are represented in the model along with 16 muscles, 3 joints and 3 extracapsular ligaments. The locations of the humerus and shoulder girdle that were recorded in ten subjects during loaded and unloaded humeral abduction and anteflexion are the input variables.

Conclusion:

The length dependence of electromyography (EMG) amplitude and the unknown force-length relationship makes it difficult to compare muscle force predictions and EMG measurements. The conclusion is that complicated musculoskeletal models cannot be validated using EMG amplitude. The force and moment balance of the three joints are used to examine the function of the muscles. This model allows for an investigation of the function of morphological components and offers useful insight into the mechanics of the shoulder mechanism.
Assessing the efficacy of a novel sperm-washing medium enriched with serotonin, L-carnitine, and coenzyme Q10: an observational cohort study
Authors: Dogan Sinem , Aydin Turgut , Koroglu Nadiye , Yilmazer Yasemin , Albayrak Nazli , Cetin Fadime , Moshfeghi Elnaz , Celik Ozge
Published: June 2024

This observational cohort study investigated the potential of a novel sperm-washing medium (SWM) enriched with serotonin (5-HT), L-carnitine (L-C), and coenzyme Q10 (CoQ10) to enhance sperm motility and reduce DNA damage. It compared this innovative medium (5-HT/L-C/CoQ10 SWM) with two widely used commercial media (SWM 1 and SWM 2). Ninety-eight volunteers from an infertility clinic provided semen samples, which were divided into three aliquots for analysis in different SWMs: group 1, SWM was composed of hydroxyethyl piperazineethanesulfonic acid (HEPES), sodium bicarbonate, human serum albumin (HSA), taurine, and gentamicin sulfate (SWM 1); group 2, SWM was composed of HEPES, sodium bicarbonate, and HSA (SWM 2); and group 3, SWM was composed of HEPES-buffered human tubal fluid supplemented with 5-HT, L-C, and CoQ10 (5-HT/L-C/CoQ10 SWM). Sperm motility was categorized as progressive, nonprogressive, or immotile. Apoptosis, reactive oxygen species (ROS) production, and DNA fragmentation were also assessed. There were no significant differences in total or progressive sperm motility among the groups. Spermatozoa in group 3 exhibited reduced apoptosis, necrosis, and ROS levels and increased viability. No significant differences were observed in the DNA fragmentation index among groups. The 5-HT/L-C/CoQ10 SWM reduced sperm oxidative stress and apoptosis compared with those of the two commercially available SWMs, suggesting that 5-HT/L-C/CoQ10 SWM could be useful for enhancing in vitro fertilization success rates.
Clinicopathological profile of the patients with lung cancer at a tertiary care institute from South India
Authors: Reddy Rachita , Venkat Rakshith Jaya , Narayanan Geeta S. , Kumar B. R. Kiran
Published: June 2024

BACKGROUND AND OBJECTIVE:

Lung cancer is one of the most aggressive and prevalent types of malignancy, causing high morbidity and mortality. Tobacco smoking continues to be the leading cause of lung cancer worldwide. An increasing incidence of lung cancer has been observed in India. The objective of this study is to find the demographic and clinicopathological profile of patients with lung cancer presented at our center over 2 years.

METHODS:

A retrospective analysis of all the patients diagnosed with lung cancer presented to our institute between 2015 and 2017 was done. All the patients’ records were statistically analyzed for demographic features, smoking status, histopathological type, stage of the disease at presentation, and treatment modalities.

RESULTS:

A total of 218 diagnosed cases of lung cancer were included in the study. The majority (78%) were males, with 170 cases. The median age of diagnosis is 62 years. Smoking emerged as a prominent risk factor, with smokers comprising 33% of patients with lung cancer. Nonsmall-cell carcinoma (NSCLC) is the most common histology and adenocarcinoma was detected among 50.5% of patients of NSCLC patients. Among all patients Stage IV accounting for the highest percentage. Bone and liver were the most common sites of distant metastasis. In terms of treatment patterns, the data indicated that 33.49% of cases received curative treatment, and 53.67% opted for palliative care.

CONCLUSION:

Adenocarcinoma was the most common NSCLC in our studied population where the majority of patients with lung cancer were nonsmokers. Stage IV presentation with bone metastasis was the most common clinical presentation.
A randomized comparative clinical trial to evaluate the efficacy of Chatushashti Prahari Pippali along with Rehabilitation self-management after COVID-19 related illness in the management of post COVID syndrome
Authors: Walinjkar Manjiri Jayprakash , Goyal Mandip
Published: June 2024

Background:

The COVID-19 pandemic along with post-COVID-19 syndrome (PCS) has raised many questions to the medical fraternity for which Ayurveda can be the solution for abatement of the disease along with its prevention and treatment.

Aim:

The present prospective double-arm randomized controlled clinical study was undertaken with the aim to evaluate the role of Chatushashti Prahari Pippali (CPP) as addon to rehabilitation guidelines in PCS, in comparison with rehabilitation guidelines on the relief in the symptoms as the primary outcome and upgradation of quality of life (QoL) as the secondary outcome.

Materials and methods:

A total of 112 patients of PCS were selected and randomized into two groups, namely group A and group B, in which intervention was encapsulated CPP and placebo, respectively. The posology of oral intervention in both groups was 500 mg capsulated powder twice a day after food with lukewarm water for 8 weeks, along with rehabilitation guidelines. Both the groups were assessed based on subjective and objective parameters such as symptomatic gradation, 6 min walk test (6MWT), and Quality of life.

Results:

Results were obtained by descriptive and inferential statistical methods, including ANOVA, ANCOVA, and paired t-tests. Statistically significant difference was reported between the groups in all assessment parameters, including symptomatic improvement, upgrading in 6MWT with the enhancement of QoL assessed by the WHO QoL and Post-COVID-19 Functional Scale, which validates the superiority of combined therapy (CPP and rehabilitation) over only rehabilitation in the management of PCS.

Conclusion:

The present study provides credible evidence that the Ayurveda intervention CPP along with rehabilitation is effective in the management of PCS in enhancing the QoL of COVID-19 long-haulers, justifying the need for medicinal intervention along with rehabilitation.
Herbal pharmaceutical patent protection: Illustrative evidence on prosecution stages and section 3 [d] implication of Indian Patent Act
Authors: Sharma Parul , Ravikumar R. K.
Published: June 2024

Background:

Pharmaceutical industries are increasingly vigilant on filing patent protection in the field of herbal medicine due to increase in annual growth rate/demand of natural products. These industries dependant on medicinal system(s) primarily on AYUSH system of Medicine apart from traditional knowledge practices. Since 2005, India had complied with Trade Related Aspects of Intellectual Property Rights [TRIPS] obligations by evolving suitable patent protection system. Indian patent system had advanced by various amendment(s) including Section 3 (d) of the Act (Patent Act 1970).

Aim:

The study is aimed essential to provide evidence in protection of desirable patent and to understand implications of Section 3 (d) in terms of protecting creativity, appreciating variations in development of pharmaceutical products.

Material and methods:

The study had examined 41 herbal pharmaceutical patent grants from grassroots innovations during 2021 to 2022 incubated by National Innovation Foundation-India. The implications of pharmaceutical grants with respect to Section 3 (d) were elaborated.

Results:

It was encouraging to note that 24 percent of these applications were accorded with herbal pharmaceutical product patent grants. The study observed that on an average these applications received grant by seven years with a prosecution period of 19 months.

Conclusion:

These features reflect evolving nature of IP regime in dealing with herbal pharmaceutical patent applications as India is recognized as an innovation economy. The contribution of green grassroots innovation in public health care is illustrated.