bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Suboptimal Peak Inspiratory Flow in Patients with Stable COPD
Authors: Represas-Represas Cristina , Aballe-Santos Luz , Fernández-García Alberto , Priegue-Carrera Ana , López-Campos José-Luis , González-Montaos Almudena , Botana-Rial Maribel , Fernández-Villar Alberto
Published: December 2020

Objective: Although the importance of assessing inspiratory flow in the selection of treatments for chronic obstructive pulmonary disease (COPD) is understood, evaluation of this factor is not yet widespread or standardized. The objective of the present work was to evaluate the peak inspiratory flow (PIF) of patients with COPD and to explore the variables associated with a suboptimal PIF. Methods: An observational, cross-sectional study was carried out at specialized nursing consultations over a period of 6 months. We collected clinical data as well as data on symptoms, treatment adherence, and patient satisfaction with their inhalers via questionnaires. PIF was determined using the In-Check Dial G16® device (Clement Clarke International, Ltd., Harlow, UK). In each case, the PIF was considered suboptimal when it was off-target for any of the prescribed inhalers. The association with suboptimal PIF was evaluated using multivariate logistic regression and the results were expressed as the odds ratio (OR) with 95% confidence interval (CI). Results: A total of 122 COPD patients were included in this study, of whom 34 (27.9%) had suboptimal PIF. A total of 229 inhalers were tested, of which 186 (81.2%) were dry powder devices. The multivariate analysis found an association between suboptimal PIF and age (OR = 1.072; 95% CI (1.019, 1.128); p = 0.007) and forced vital capacity (OR = 0.961; 95% CI (0.933, 0.989); p = 0.006). Conclusions: About a third of patients in complex specialized COPD care have suboptimal PIFs, which is related to age and forced vital capacity.
Pressure Signal Analysis for the Characterization of High-Viscosity Two-Phase Flows in Horizontal Pipes
Authors: Torres Lizeth , Noguera José , Guzmán-Vázquez José Enrique , Hernández Jonathan , Sanjuan Marco , Palacio-Pérez Arturo
Published: December 2020

We study a high-viscosity two-phase flow through an analysis of the corresponding pressure signals. In particular, we investigate the flow of a glycerin–air mixture moving through a horizontal pipeline with a U-section installed midway along the pipe. Different combinations of liquid and air mass flow rates are experimentally tested. Then, we examine the moments of the statistical distributions obtained from the resulting pressure time series, in order to highlight the significant dynamical traits of the flow. Finally, we propose a novel correlation with two dimensionless parameters: the Euler number and a mass-flow-rate ratio to predict the pressure gradient in high-viscosity two-phase flow. Distinctive variations of the pressure gradients are observed in each section of the pipeline, which suggest that the local flow dynamics must not be disregarded in favor of global considerations.
Grizzly Bear Management in the Kananaskis Valley: Forty Years of Figuring It Out
Authors: Carruthers Den Hoed Don , Murphy Michelle N. , Halpenny Elizabeth A. , Mucha Debbie
Published: December 2020

Case studies offer rich insight into the way knowledge is gathered, understood, and applied (or not) in parks and conservation contexts. This study aims to understand how knowledge and information have been used to inform decision-making about human-wildlife co-existence—specifically what knowledge has informed decisions related to grizzly bear management in the Kananaskis Valley. Focus groups of decision-makers involved in the valley’s bear program painted a rich account of decision-making since the late 1970s that was coded thematically. Our findings suggest there are typical impacts on knowledge mobilization, such as management support (or lack thereof), other agencies, capacity, and social and political pressures. In addition, the special context of the Kananaskis Valley and the forty-year timespan explored in focus group conversations provide unique lenses through which to understand knowledge mobilization. This case study reflects the barriers identified in the literature. However, the findings also include unique aspects of decision-making, such as the evolution of decision-making over a period of time in a multi-use landscape, the successful creation of networks to mediate knowledge and practice, and the creation of knowledge by practitioners.
Retrieval of Prefabricated Zirconia Crowns with Er,Cr:YSGG Laser from Primary and Permanent Molars
Authors: Deeb Janina Golob , McCall Connor , Carrico Caroline K. , Dahlke William O. , Grzech-Leśniak Kinga
Published: December 2020

(1) Background: Prefabricated zirconia crowns are used to restore teeth in children. The purpose of this study was to evaluate the removal of these crowns with the erbium, chromium: yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser; (2) Methods: A total of 12 primary and 12 permanent teeth were prepared and prefabricated zirconia crowns were passively fitted and cemented with two resin modified glass-ionomer (RMGI) cements. Surface areas of prepared teeth and crowns were calculated. Crowns were removed using two laser settings: 4.5 Watts, 15 Hertz, 20 water/20 air, and 5 Watts, 15 Hertz, 50 water/50 air. The retrieval time and temperature changes were tested recorded. Data were analyzed using ANOVA with Tukey’s adjusted post hoc pairwise comparison t-test; (3) Results: The average time for crown removal was: 3 min, 47.7 s for permanent; and 2 min 5 s for primary teeth. The mean temperature changes were 2.48 °C (SD = 1.43) for permanent; and 3.14 °C (SD = 1.88) for primary teeth. The time to debond was significantly positively correlated with tooth inner surface area and volume, outer crown volume, and the cement volume; (4) Conclusions: Use of the Er,Cr:YSGG laser is an effective, safe and non-invasive method to remove prefabricated zirconia crowns cemented with RMGI cements from permanent and primary teeth.
The Experimental Process Design of Artificial Lightweight Aggregates Using an Orthogonal Array Table and Analysis by Machine Learning
Authors: Wie Young Min , Lee Ki Gang , Lee Kang Hyuck , Ko Taehoon , Lee Kang Hoon
Published: December 2020

The purpose of this study is to experimentally design the drying, calcination, and sintering processes of artificial lightweight aggregates through the orthogonal array, to expand the data using the results, and to model the manufacturing process of lightweight aggregates through machine-learning techniques. The experimental design of the process consisted of L18(3661), which means that 36 × 61 data can be obtained in 18 experiments using an orthogonal array design. After the experiment, the data were expanded to 486 instances and trained by several machine-learning techniques such as linear regression, random forest, and support vector regression (SVR). We evaluated the predictive performance of machine-learning models by comparing predicted and actual values. As a result, the SVR showed the best performance for predicting measured values. This model also worked well for predictions of untested cases.
Nanocluster-Based Ultralow-Temperature Driven Oxide Gate Dielectrics for High-Performance Organic Electronic Devices
Authors: Jo Jeong-Wan , Kang Jingu , Kim Kyung-Tae , Kang Seung-Han , Shin Jae-Cheol , Shin Seung Beom , Kim Yong-Hoon , Park Sung Kyu
Published: December 2020

The development of novel dielectric materials with reliable dielectric properties and low-temperature processibility is crucial to manufacturing flexible and high-performance organic thin-film transistors (OTFTs) for next-generation roll-to-roll organic electronics. Here, we investigate the solution-based fabrication of high-k aluminum oxide (Al2O3) thin films for high-performance OTFTs. Nanocluster-based Al2O3 films fabricated by highly energetic photochemical activation, which allows low-temperature processing, are compared to the conventional nitrate-based Al2O3 films. A wide array of spectroscopic and surface analyses show that ultralow-temperature photochemical activation (<60 °C) induces the decomposition of chemical impurities and causes the densification of the metal-oxide film, resulting in a highly dense high-k Al2O3 dielectric layer from Al-13 nanocluster-based solutions. The fabricated nanocluster-based Al2O3 films exhibit a low leakage current density (<10−7 A/cm2) at 2 MV/cm and high dielectric breakdown strength (>6 MV/cm). Using this dielectric layer, precisely aligned microrod-shaped 2,7-dioctyl[1]benzothieno [3,2-b][1] benzothiophene (C8-BTBT) single-crystal OTFTs were fabricated via solvent vapor annealing and photochemical patterning of the sacrificial layer.
Study of Mechanical Properties and Durability of Alkali-Activated Coal Gangue-Slag Concrete
Authors: Zhu Hongguang , Yang Sen , Li Weijian , Li Zonghui , Fan Jingchong , Shen Zhengyan
Published: December 2020

Herein, a new geopolymer is recognized as a potential alternative cementing material of ordinary Portland cement (OPC), which is used for reducing carbon emissions and efficiently recycling the waste. Therefore this paper mainly studied the alkali-activated coal gangue-slag concrete (ACSC) was prepared by using the coal gangue-slag and Na2SiO3 and NaOH complex activator. The ratio of coal gangue (calcined and uncalcined) coarse aggregate replacing the gravel was 0%, 30%, 50%, 70%, and 100%. The water and salt freeze-thaw resistance, compressive strength, chloride permeation, microstructure, performance mechanism, inner freeze-thaw damage distribution, and mechanics models of ACSC were investigated. Results show that ACSC displayed excellent early age compressive strength, and the compact degree and uniformity of structure were better compared with the ordinary Portland cement (OPC) when the coal gangue replacement rate was less than 50%. The ACSC demonstrated the best chloride penetration resistance under 30% uncalcined coal gangue content, which was less than 27.75% lower than that of using OPC. At the same number cycles, especially in the salt freezing, the calcined coal gangue had lowered advantages of improving resistance freeze-thaw damage resistance. Water and salt accumulative freeze-thaw damage mechanics models of ACSC were established by using the relative dynamic elasticity modulus. The exponential function model was superior to the power function model with better precision and relativity, and the models accurately reflected the freeze-thaw damage effect.
Modification of Surface Hydrophobicity of PLA/PE and ABS/PE Polymer Blends by ICP Etching and CFx Coating
Authors: Lovinčić Milovanović Vedrana , Guyon Cédric , Grčić Ivana , Tatoulian Michael , Vrsaljko Domagoj
Published: December 2020

The flow regime inside the channel of 3D printed microreactors is defined by the surface properties of the channel walls. Polylactide (PLA) and acrylonitrile/butadiene/styrene (ABS) are two polymers that are the most common in additive manufacturing using fused filament fabrication, commonly known as “3D printing”. With the aim of developing new materials for the 3D printing of microreactors whose channel surface hydrophobicity could be modified, PLA and ABS were blended with cheaper and widely used polymers-high-density polyethylene (PE-HD) and low-density polyethylene (PE-LD). Polymer blend surfaces were treated with inductively coupled plasma (ICP) and coated by fluorocarbon-based material (CFx) plasma deposition treatment in order to modify surface hydrophobicity. It has been shown that the modification of surface morphology of PLA polymer blends can be achieved by ICP etching and CFx coating, while this was not possible for ABS polymer blends under the conducted treatment conditions. The treated surface of PLA/PE-HD 90/10 showed a contact angle of 121.6° which is 36° higher than the contact angle measured on the untreated surface. Surfaces that have achieved contact angles higher than 120° have an “island like” surface morphology. Samples with higher “islands” showed higher contact angles, that confirmed that the hydrophobicity also depends on the height of the “islands”. Furthermore, it has been found that etching time significantly impacts the contact angle values and surface morphology of the PLA polymer blends, while the CFx coating time does not have significant impact on the surface properties.
Bending Behaviour of Polymeric Materials Used on Biomechanics Orthodontic Appliances
Authors: Domagała Ivo , Przystupa Krzysztof , Firlej Marcel , Pieniak Daniel , Niewczas Agata , Biedziak Barbara
Published: December 2020

This paper discusses the issues of strength and creep of polymeric materials used in orthodontic appliances. Orthodontic biomechanics is focused on the movement of individual teeth or dental groups as a result of the force applied by orthodontic appliances. Stresses in the construction of functional and biomechanical appliances is generated when using the apparatus in the oral cavity. The orthodontic appliance must maintain its shape and not be damaged during treatment so strength and creep resistance are fundamental properties. It was assumed that the clinical success of orthodontic appliances can be determined by these performance properties. The aim of the work was the experimental assessment of comparative bending strength and creep resistance of selected popular polymer materials used in the production of biomechanical orthodontic appliances. Four commercial materials manufactured by the world class producers were tested: NextDent Ortho Rigid (Vertex-Dental B.V., Soesterberg, The Netherlands) marked as “1A”; Erkocryl (ERKODENT Erich Kopp GmbH, Pfalzgrafenweiler, Germany)-“2A”; Vertex Orthoplast (Vertex Dental B.V.), blue, marked as “3A” and material with the same name as “3A” but orange, marked in the article as “4A”. All the tests were carried out after aging in artificial saliva for 48 h at a temperature of 37 °C. Flexular strength and flexular modulus were made using the three point bending method according to the ISO 178 technical standard. Creep tests were carried out according to the method contained in ISO 899-2. The creep test was carried out in an artificial saliva bath at 37 °C. The creep tests showed significant differences in the strength, modulus and deformability of the tested materials. The strength reliability of the tested materials also varied. The research shows that the 2A material can be used for orthodontic applications in which long-term stresses should be lower than 20 MPa.
Effect of Selected Cooling and Deformation Parameters on the Structure and Properties of AISI 4340 Steel
Authors: Eckert Maros , Krbata Michal , Barenyi Igor , Majerik Jozef , Dubec Andrej , Bokes Michal
Published: December 2020

The paper is focused on investigation of the high-strength AISI 4340 steel at various temperature and deformation conditions. The article is divided into two specific analyses. The first is to examine the dilatation behavior of the steel at eight different cooling rates, namely, 100, 10, 5, 1, 0.5, 0.1, 0.05 and 0.01 °C·s−1. The mapping of the phase transformations due to varying cooling rates from the austenitizing temperature of 850 °C allows the construction of the CCT diagram for a given high-strength steel. These dilatation curves were also compared with the metallography of the selected samples for the proper construction of the CCT diagram. A further analysis of the high temperature deformation of high strength steel AISI 4340 was performed in the range of temperature 900–1200 °C, and the strain rate was in the range from 0.001 to 10 s−1 with maximum value of the true strain 0.9. Changes in the microstructure were observed using light optical microscopy (LOM). The effect of hot deformation temperature on true stress, peak stress and true strain was investigated. The hardness of all deformed samples, depending on the temperature, the deformation rate and the peak stress σp overall together related with hardness, has also been evaluated.
Analysis on the Effects of External Temperature and Welding Speed on the Safety of EVA Waterproofing Sheet Joints by Hot Air Welding
Authors: Park Wan-Goo , Choi Su-Young , Park Jin-Sang , Kim Dong-Bum , He Xing-Yang , Oh Sang-Keun
Published: December 2020

This study analyzes the optimal seasonal ambient temperature during welding and welding speed conditions for securing high tensile strength of ethylene vinyl acetate (EVA) waterproofing sheets bonded for roofing, installed by hot air welded joints (overlaps). Seven separate ambient temperature conditions (−10, −5, and 0 °C for winter conditions, 20 °C for the normal condition, and 25, 30, and 35 °C for summer conditions) were set for the test variable and seven speed conditions (3, 4, 5, 6, 7, 8, and 9 m/min) for hot air welding. Based on these conditions, EVA sheet joint specimens were prepared, and the tensile strength of the joint sections was tested and measured. Tensile strength results, compared to normal temperature conditions (20 °C) showed an increase in the summer temperature condition but a decrease during winter temperature conditions. The analysis on the effects of the welding speed showed that in summer temperature conditions (25, 30, and 35 °C), the optimum hot air welding speed is 4.3~9.0 m/min at 25 °C, 4.7~8.7 m/min at 30 °C and 5.2~8.6 m/min at 35 °C, whereas in winter (−10, −5, and 0 °C), the optimum hot air welding temperature is 3~4.1 m/min at −10 °C, 3~4.6 m/min at −5 °C and 3~4.9 m/min at 0 °C. Research results demonstrate that it is imperative to consider the welding speed in accordance to the respective seasonal temperature conditions to secure construction quality of the EVA joints for roofing.
Tooth-Colored CAD/CAM Materials for Application in 3-Unit Fixed Dental Prostheses in the Molar Area: An Illustrated Clinical Comparison
Authors: Rauch Angelika , Hahnel Sebastian , Günther Elena , Bidmon Wolfgang , Schierz Oliver
Published: December 2020

The aim of this study was to compare the clinical properties of tooth-colored computer-aided design/computer-aided manufacturing (CAD/CAM) materials for the fabrication of a 3-unit fixed dental prostheses (FDPs) in the same clinical scenario. A 53-year-old female patient was supplied with a 3-unit FDP to replace a second premolar in the upper jaw. Restorations were fabricated from 3 mol%, 4 mol%, and 5 mol% yttrium oxide zirconia, zirconia with translucency gradient, indirect composite resin, polyetheretherketone (PEEK), and polyetherketoneketone (PEKK). Milling time, weight, and radiopacity were investigated. Esthetics were examined following the US Public Health Service criteria (USPHS). The milling time for zirconia was twice as high as for the indirect composite resin, PEEK, or PEKK. The latter materials had a weight of 2 g each, while zirconia restorations yielded 5 g. Zirconia presented intense radiopacity. PEEK and PEKK required veneering and an opaquer was applied to the PEKK framework. All FDPs showed acceptable esthetics. PEEK and PEKK restorations were featured by a grayish shimmering. A variety of CAD/CAM materials are available to fabricate 3-unit FDPs with esthetically acceptable results. In the esthetic zone, PEEK and PEKK require veneering and an opaquer might be applied. Milling time, weight, and radiopacity were relatively high for zirconia FDPs.
Review on Adhesives and Surface Treatments for Structural Applications: Recent Developments on Sustainability and Implementation for Metal and Composite Substrates
Authors: Marques Ana , Mocanu Alexandra , Tomić Nataša , Balos Sebastian , Stammen Elisabeth , Lundevall Asa , Abrahami Shoshan , Günther Roman , de Kok John , Teixeira de Freitas Sofia
Published: December 2020

Using adhesives for connection technology has many benefits. It is cost-efficient, fast, and allows homogeneous stress distribution between the bonded surfaces. This paper gives an overview on the current state of knowledge regarding the technologically important area of adhesive materials, as well as on emergent related technologies. It is expected to fill some of the technological gaps between the existing literature and industrial reality, by focusing at opportunities and challenges in the adhesives sector, on sustainable and eco-friendly chemistries that enable bio-derived adhesives, recycling and debonding, as well as giving a brief overview on the surface treatment approaches involved in the adhesive application process, with major focus on metal and polymer matrix composites. Finally, some thoughts on the connection between research and development (R&D) efforts, industry standards and regulatory aspects are given. It contributes to bridge the gap between industry and research institutes/academy. Examples from the aeronautics industry are often used since many technological advances in this industry are innovation precursors for other industries. This paper is mainly addressed to chemists, materials scientists, materials engineers, and decision-makers.
Research on Microstructure and Mechanical Properties of Rheological Die Forging Parts of Al-6.54Zn-2.40Cu-2.35Mg-0.10Zr(-Sc) Alloy
Authors: Zheng Hansen , Zhang Zhifeng , Bai Yuelong , Xu Yongtao
Published: December 2020

High-strength aluminum alloy (mainly refers to the 7xxx series) is the optimum material for lightweight military equipment. However, this type of aluminum alloy is a wrought aluminum alloy. If it is directly formed by traditional casting methods, there will inevitably be problems such as coarseness, unevenness, looseness, and hot cracking in the structure, which will greatly affect the final performance of the part. Based on the internal cooling with annular electromagnetic stirring (IC-AEMS) method, a new technology of rheological die forging is developed in this paper, and the scale-reduced parts of a brake hub of Al-6.54Zn-2.40Cu-2.35Mg-0.10Zr aluminum alloy were prepared. The influence of IC-AEMS and the addition of rare element Sc on the structure and mechanical properties of the parts was studied. An optical microscope and scanning electron microscope (SEM) were used to observe the microstructure evolution, energy dispersive spectroscopy (EDS) was used to analyze the phase distribution and composition, and the mechanical properties of the parts were tested by uniaxial tensile tests. The results show that the addition of Sc element can effectively refine the grains and improve the strength and elongation of the material; the application of IC-AEMS improves the cooling rate of the melt, increases the effective nucleation rate, and the grains are further refined. Through process optimization, scale-reduced parts of a brake hub with good formability and mechanical properties can be obtained, the ultimate tensile strength is 597.2 ± 3.1 MPa, the yield strength is 517.8 ± 4.3 MPa, and the elongation is 13.7 ± 1.3%.
Oxygen Vacancies in Perovskite Oxide Piezoelectrics
Authors: Tyunina Marina
Published: December 2020

The excellent electro-mechanical properties of perovskite oxide ferroelectrics make these materials major piezoelectrics. Oxygen vacancies are believed to easily form, migrate, and strongly affect ferroelectric behavior and, consequently, the piezoelectric performance of these materials and devices based thereon. Mobile oxygen vacancies were proposed to explain high-temperature chemical reactions half a century ago. Today the chemistry-enabled concept of mobile oxygen vacancies has been extrapolated to arbitrary physical conditions and numerous effects and is widely accepted. Here, this popular concept is questioned. The concept is shown to conflict with our modern physical understanding of ferroelectrics. Basic electronic processes known from mature semiconductor physics are demonstrated to explain the key observations that are groundlessly ascribed to mobile oxygen vacancies. The concept of mobile oxygen vacancies is concluded to be misleading.
Use of Coal Bottom Ash and CaO-CaCl2-Activated GGBFS Binder in the Manufacturing of Artificial Fine Aggregates through Cold-Bonded Pelletization
Authors: Jeon Dongho , Yum Woo , Song Haemin , Yoon Seyoon , Bae Younghoon , Oh Jae
Published: December 2020

This study investigated the use of coal bottom ash (bottom ash) and CaO-CaCl2-activated ground granulated blast furnace slag (GGBFS) binder in the manufacturing of artificial fine aggregates using cold-bonded pelletization. Mixture samples were prepared with varying added contents of bottom ash of varying added contents of bottom ash relative to the weight of the cementless binder (= GGBFS + quicklime (CaO) + calcium chloride (CaCl2)). In the system, the added bottom ash was not simply an inert filler but was dissolved at an early stage. As the ionic concentrations of Ca and Si increased due to dissolved bottom ash, calcium silicate hydrate (C-S-H) formed both earlier and at higher levels, which increased the strength of the earlier stages. However, the added bottom ash did not affect the total quantities of main reaction products, C-S-H and hydrocalumite, in later phases (e.g., 28 days), but simply accelerated the binder reaction until it had occurred for 14 days. After considering both the mechanical strength and the pelletizing formability of all the mixtures, the proportion with 40 relative weight of bottom ash was selected for the manufacturing of pilot samples of aggregates. The produced fine aggregates had a water absorption rate of 9.83% and demonstrated a much smaller amount of heavy metal leaching than the raw bottom ash.
Recovery and Characterization Studies of Post-Production Alloy Waste from the Automotive Industry
Authors: Żelazny Sylwester , Żukowski Witold , Bogdał Dariusz , Bednarz Szczepan , Kasprzyk Wiktor , Świergosz Tomasz
Published: December 2020

Superalloys provide high corrosion resistance and are widely used as high-performance materials in aerospace, automotive, chemical, and other industries. Herein, the investigation into the characteristics and properties of alloy waste; Inconel 625, Inconel 718, and Titanium Grade 5, from the automotive industry, was introduced as a result of a recovery in various processes. For this reason, the following procedures were carried as follows; the washing process to remove oil from the swarf was evaluated using several commercial agents and for the process of thermal disposal of processing fluids, a temperature of 900 °C was used in a muffle furnace without air access. The presented studies show that the commercially available series of washing agents did not modify the composition of the surface. However, the high temperatures during the calcination of oil residues are affecting the elemental composition of the alloys. According to the results of the analyses, it is not possible to remove 100% of the oil residues from alloy waste using washing agents based on light organic fractions; however, the effectiveness of this method reaches 99%. In this report, accurate SEM-EDS analyses show changes that occur on the surface after machining and removal of processing fluids. The NMR and GC/MS investigations indicate contaminants as a mixture of aliphatic and cycloaliphatic hydrocarbons with carbon numbers from C8–C30.
Catalysts for Hydrogen Generation via Oxy–Steam Reforming of Methanol Process
Authors: Mosińska Magdalena , Szynkowska-Jóźwik Małgorzata I. , Mierczyński Paweł
Published: December 2020

The production of pure hydrogen is one of the most important problems of the modern chemical industry. While high volume production of hydrogen is well under control, finding a cheap method of hydrogen production for small, mobile, or his receivers, such as fuel cells or hybrid cars, is still a problem. Potentially, a promising method for the generation of hydrogen can be oxy–steam-reforming of methanol process. It is a process that takes place at relatively low temperature and atmospheric pressure, which makes it possible to generate hydrogen directly where it is needed. It is a process that takes place at relatively low temperature and atmospheric pressure, which makes it possible to generate hydrogen directly where it is needed. This paper summarizes the current state of knowledge on the catalysts used for the production of hydrogen in the process of the oxy–steam-reforming of methanol (OSRM). The development of innovative energy generation technologies has intensified research related to the design of new catalysts that can be used in methanol-reforming reactions. This review shows the different pathways of the methanol-reforming reaction. The paper presents a comparison of commonly used copper-based catalysts with other catalytic systems for the production of H2 via OSRM reaction. The surface mechanism of the oxy–steam-reforming of methanol and the kinetic model of the OSRM process are discussed.
Efficient and Secure Strategy for Energy Systems of Interconnected Farmers′ Associations to Meet Variable Energy Demand
Authors: Raboaca Maria Simona , Bizon Nicu , Trufin Catalin , Enescu Florentina Magda
Published: December 2020

Since ancient times, agriculture has been one of the most important resources of national development. At a national level, clean energy is a strategic objective of Romania, in accordance with the EC directive 2016/30.11.2016 (“Clean Energy for All”). At a European level, the European Commission published in January 2019 the “Towards a Sustainable Europe by 2030” strategy, highlighting the strategic importance of the Internet of Things (IoT) and blockchain technologies. In this context, the synergy between the energy management of a hybrid energy system and blockchain technology, applied to farmers’ associations, represents a priority research direction in the field of information and communication technology, blockchain, and security. This paper presents the integration of the management of the energy produced by photovoltaic panels owned by farmers’ association, to support the variable energy demand (necessary for water pumps, charging stations of the electric agricultural machines, the animal farms, and the auxiliary equipment) based on the IoT, DLT, blockchain technologies and smart contracts applied to farmers associations registered as users of the SmartFarm platform.
Amentadione from the Alga Cystoseira usneoides as a Novel Osteoarthritis Protective Agent in an Ex Vivo Co-Culture OA Model
Authors: Araújo Nuna , Viegas Carla S. B. , Zubía Eva , Magalhães Joana , Ramos Acácio , Carvalho Maria M. , Cruz Henrique , Sousa João Paulo , Blanco Francisco J. , Vermeer Cees , Simes Dina C.
Published: December 2020

Osteoarthritis (OA) remains a prevalent chronic disease without effective prevention and treatment. Amentadione (YP), a meroditerpenoid purified from the alga Cystoseira usneoides, has demonstrated anti-inflammatory activity. Here, we investigated the YP anti-osteoarthritic potential, by using a novel OA preclinical drug development pipeline designed to evaluate the anti-inflammatory and anti-mineralizing activities of potential OA-protective compounds. The workflow was based on in vitro primary cell cultures followed by human cartilage explants assays and a new OA co-culture model, combining cartilage explants with synoviocytes under interleukin-1β (IL-1β) or hydroxyapatite (HAP) stimulation. A combination of gene expression analysis and measurement of inflammatory mediators showed that the proposed model mimicked early disease stages, while YP counteracted inflammatory responses by downregulation of COX-2 and IL-6, improved cartilage homeostasis by downregulation of MMP3 and the chondrocytes hypertrophic differentiation factors Col10 and Runx2. Importantly, YP downregulated NF-κB gene expression and decreased phosphorylated IkBα/total IkBα ratio in chondrocytes. These results indicate the co-culture as a relevant pre-clinical OA model, and strongly suggest YP as a cartilage protective factor by inhibiting inflammatory, mineralizing, catabolic and differentiation processes during OA development, through inhibition of NF-κB signaling pathways, with high therapeutic potential.
Evaluation of a Brown Seaweed Extract from Dictyosiphon foeniculaceus as a Potential Therapeutic Agent for the Treatment of Glioblastoma and Uveal Melanoma
Authors: Dörschmann Philipp , Schmitt Christina , Bittkau Kaya , Neupane Sandesh , Synowitz Michael , Roider Johann , Alban Susanne , Held-Feindt Janka , Klettner Alexa
Published: December 2020

Ingredients of brown seaweed like fucoidans are often described for their beneficial biological effects, that might be interesting for a medical application. In this study, we tested an extract from Dictyosiphon foeniculaceus (DF) to evaluate the effects in glioblastoma and uveal melanoma, looking for a possible anti-cancer treatment. We investigated toxicity, VEGF (vascular endothelial growth factor) secretion and gene expression of tumor and non-tumor cells. SVGA (human fetal astrocytes), the human RPE (retinal pigment epithelium) cell line ARPE-19, the tumor cell line OMM-1 (human uveal melanoma), and two different human primary glioblastoma cultures (116-14 and 118-14) were used. Tests for cell viability were conducted with MTS-Assay (3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium), and the proliferation rate was determined with cell counting. VEGF secretion was assessed with ELISA (enzyme-linked immunosorbent assay). The gene expression of VEGF receptor 1 (VEGFR1), VEGF receptor 2 (VEGFR2) and VEGF-A was determined with real-time qPCR (quantitative polymerase chain reaction). DF lowered the cell viability of OMM-1. Proliferation rates of ARPE-19 and OMM-1 were decreased. The VEGF secretion was inhibited in ARPE-19 and OMM-1, whereas it was increased in SVGA and 116-14. The expression of VEGFR1 was absent and not influenced in OMM-1 and ARPE-19. VEGFR2 expression was lowered in 116-14 after 24 h, whereas VEGF-A was increased in 118-14 after 72 h. The extract lowered cell viability slightly and was anti-proliferative depending on the cell type investigated. VEGF was heterogeneously affected. The results in glioblastoma were not promising, but the anti-tumor properties in OMM-1 could make them interesting for further research concerning cancer diseases in the human eye.
Gas Transport in Glassy Polymers
Authors: De Angelis Maria Grazia , Sarti Giulio C.
Published: December 2020

This Special Issue of Membranes provides an updated and comprehensive overview of the state of fundamental knowledge on the fluid sorption and transport in glassy polymers, combining original experimental and modeling works, as well as reviews, prepared by renowned experts [...]
Effect of Water and Organic Pollutant in CO2/CH4 Separation Using Hydrophilic and Hydrophobic Composite Membranes
Authors: Casado-Coterillo Clara , Garea Aurora , Irabien Ángel
Published: December 2020

Membrane technology is a simple and energy-conservative separation option that is considered to be a green alternative for CO2 capture processes. However, commercially available membranes still face challenges regarding water and chemical resistance. In this study, the effect of water and organic contaminants in the feed stream on the CO2/CH4 separation performance is evaluated as a function of the hydrophilic and permselective features of the top layer of the membrane. The membranes were a commercial hydrophobic membrane with a polydimethylsiloxane (PDMS) top layer (Sulzer Chemtech) and a hydrophilic flat composite membrane with a hydrophilic [emim][ac] ionic liquid–chitosan (IL–CS) thin layer on a commercial polyethersulfone (PES) support developed in our laboratory. Both membranes were immersed in NaOH 1M solutions and washed thoroughly before characterization. The CO2 permeance was similar for both NaOH-treated membranes in the whole range of feed concentration (up to 250 GPU). The presence of water vapor and organic impurities of the feed gas largely affects the gas permeance through the hydrophobic PDMS membrane, while the behavior of the hydrophilic IL–CS/PES membranes is scarcely affected. The effects of the interaction of the contaminants in the membrane selective layer are being further evaluated.
Plastically-Induced Volume Deformation of Nanocrystalline α-Fe with a <110> Columnar Structure
Authors: Gil Sevillano J. , Aldazabal I. , Aldazabal J.
Published: December 2020

Volume changes accompanying the plastic deformation at 300 K of nanocrystalline samples of α-Fe with a columnar grain structure possessing a ⟨11¯0⟩ random fiber texture has been obtained from molecular dynamics (MD) simulations. The samples were strained in tension along the common axial direction of the columnar grains. After removal of the elastic volume change, the evolution of plastic volume strain was obtained. Small but non-negligible volume dilations or contractions are observed depending on size (samples of very small grain size show volume contraction). The rate of volume change is high during the first 10% plastic deformation and continues at a low pace thereafter; the first 10% deformation represents a transient in the stress–strain behavior too. The complex behavior observed is reasonably explained by the superposition of contributions from different plastically-induced structural changes to the mass density change: Mainly from changes of grain size, grain boundary structure, dislocation density and density of point-defects. The results are of interest for the development of crystal plasticity theories not restricted by the volume conserving assumption.
Compliant Nano-Pliers as a Biomedical Tool at the Nanoscale: Design, Simulation and Fabrication
Authors: Buzzin Alessio , Cupo Serena , Giovine Ennio , de Cesare Giampiero , Belfiore Nicola Pio
Published: December 2020

This paper presents the development of a multi-hinge, multi-DoF (Degrees of Freedom) nanogripper actuated by means of rotary comb drives and equipped with CSFH (Conjugate Surface Flexure Hinges), with the goal of performing complex in-plane movements at the nanoscale. The design approach, the simulation and a specifically conceived single-mask fabrication process are described in detail and the achieved results are illustrated by SEM images. The first prototype presents a total overall area of (550 × 550) μm2, an active clamping area of (2 × 4) μm2, 600 nm-wide circular curved beams as flexible hinges for its motion and an aspect ratio of about 2.5. These features allow the proposed system to grasp objects a few hundred nanometers in size.
Early Cretaceous Plume–Ridge Interaction Recorded in the Band-e-Zeyarat Ophiolite (North Makran, Iran): New Constraints from Petrological, Mineral Chemistry, and Geochronological Data
Authors: Barbero Edoardo , Delavari Morteza , Dolati Ashgar , Vahedi Leila , Langone Antonio , Marroni Michele , Pandolfi Luca , Zaccarini Federica , Saccani Emilio
Published: December 2020

The North Makran domain (southeast Iran) is part of the Makran accretionary wedge and consists of an imbricate stack of continental and Neo-Tethyan oceanic tectonic units. Among these, the Band-e-Zeyarat ophiolite consists of (from bottom to top): ultramafic cumulates, layered gabbros, isotropic gabbros, a sheeted dyke complex, and a volcanic sequence. Sheeted dykes and volcanic rocks are mainly represented by basalts and minor andesites and rhyolites showing either normal-type (N) or enriched-type (E) mid-ocean ridge basalt affinities (MORB). These conclusions are also supported by mineral chemistry data. In addition, E-MORBs can be subdivided in distinct subtypes based on slightly different but significant light rare earth elements, Th, Nb, TiO2, and Ta contents. These chemical differences point out for different partial melting conditions of their mantle sources, in terms of source composition, partial melting degrees, and melting depths. U-Pb geochronological data on zircons from intrusive rocks gave ages ranging from 122 to 129 Ma. We suggest that the Band-e-Zeyarat ophiolite represents an Early Cretaceous chemical composite oceanic crust formed in a mid-ocean ridge setting by partial melting of a depleted suboceanic mantle variably metasomatized by plume-type components. This ophiolite records, therefore, an Early Cretaceous plume–ridge interaction in the Makran Neo-Tethys.
Enhanced Terahertz Amplification Based on Photo-Excited Graphene-Dielectric Hybrid Metasurface
Authors: Guan Shengnan , Cheng Jierong , Chen Tiehong , Chang Shengjiang
Published: December 2020

Graphene under optical pump has been shown to be an attractive gain medium with negative dynamic conductivity at terahertz frequencies. However, the amplification over a monolayer graphene is very weak due to its one-atom thickness. In this paper, the proposed graphene-dielectric reflective metasurface effectively improved terahertz field localization and enhanced coherent amplification. The amplification coefficient of 35 was obtained at 3.38 THz at room temperature with an infrared pump intensity of 8 W/mm2. As pump intensity increased from 0 to 15 W/mm2, we observed a loss–gain–loss transition process, which was discussed in detail through coupled-mode theory. In addition, amplification at different frequencies was achieved by merely re-optimizing the geometric parameters of the dielectric resonators. This study offers an effective solution for enhancing terahertz radiation and developing terahertz lasers.
Antibacterial and Immunomodulatory Potentials of Biosynthesized Ag, Au, Ag-Au Bimetallic Alloy Nanoparticles Using the Asparagus racemosus Root Extract
Authors: Amina Musarat , Al Musayeib Nawal M. , Alarfaj Nawal A. , El-Tohamy Maha F. , Al-Hamoud Gadah A.
Published: December 2020

Two noble metals, such as silver and gold alloy nanoparticles, were successfully synthesized by the microwave assisted method in the presence of the Asparagus racemosus root extract and were used as an antibacterial and immunomodulatory agent. The nanostuctures of the synthesized nanoparticles were confirmed by various spectroscopic and microscopic techniques. The UV-vis spectrum exhibits a distinct absorption peak at 483 nm for the bimetallic alloy nanoparticles. The microscopic analysis revealed the spherical shaped morphology of the biosynthesized nanoparticles with a particle size of 10–50 nm. The antibacterial potential of the green synthesized single metal (AgNPs and AuNPs) and bimetallic alloy nanoparticles was tested against five bacterial strains. The bimetallic alloy nanoparticles displayed the highest zone of inhibition against P. aeurgnosia and S.aureus strains when compared to single metal nanoparticles and plant extract. In addition, the inmmunomodulatory potential of the root extract of A. racemosus, AgNPs, AuNPs, and Ag-Au alloy NPs is achieved by measuring the cytokine levels in macrophages (IL-1β, IL-6, and TNF-α) and NK cells (IFN-γ) of NK92 and THP1 cells using the solid phase sandwich ELISA technique. The results showed that the root extract of A. racemosus, AgNPs, and AuNPs can reduce the pro-inflammatory cytokine levels in the macrophages cells, while Ag-Au alloy NPs can reduce cytokine responses in NK92 cells. Overall, this study shows that the microwave assisted biogenic synthesized bimetallic nanoalloy nanoparticles could be further explored for the development of antibacterial and anti-inflammatory therapies.
Portable Real-Time Detection of Pb(II) Using a CMOS MEMS-Based Nanomechanical Sensing Array Modified with PEDOT:PSS
Authors: Yen Yi-Kuang , Lai Chao-Yu
Published: December 2020

Detecting the concentration of Pb2+ ions is important for monitoring the quality of water due to it can become a health threat as being in certain level. In this study, we report a nanomechanical Pb2+ sensor by employing the complementary metal-oxide-semiconductor microelectromechanical system (CMOS MEMS)-based piezoresistive microcantilevers coated with PEDOT:PSS sensing layers. Upon reaction with Pb2+, the PEDOT:PSS layer was oxidized which induced the surface stress change resulted in a subsequent bending of the microcantilever with the signal response of relative resistance change. This sensing platform has the advantages of being mass-produced, miniaturized, and portable. The sensor exhibited its sensitivity to Pb2+ concentrations in a linear range of 0.01–1000 ppm, and the limit of detection was 5 ppb. Moreover, the sensor showed the specificity to Pb2+, required a small sample volume and was easy to operate. Therefore, the proposed analytical method described here may be a sensitive, cost-effective and portable sensing tool for on-site water quality measurement and pollution detection.
A Comparison of Gene Expression Changes in the Blood of Individuals Consuming Diets Supplemented with Olives, Nuts or Long-Chain Omega-3 Fatty Acids
Authors: Bottero Virginie , Potashkin Judith A.
Published: December 2020

Background: The Mediterranean diet, which is rich in olive oil, nuts, and fish, is considered healthy and may reduce the risk of chronic diseases. Methods: Here, we compared the transcriptome from the blood of subjects with diets supplemented with olives, nuts, or long-chain omega-3 fatty acids and identified the genes differentially expressed. The dietary genes obtained were subjected to network analysis to determine the main pathways, as well as the transcription factors and microRNA interaction networks to elucidate their regulation. Finally, a gene-associated disease interaction network was performed. Results: We identified several genes whose expression is altered after the intake of components of the Mediterranean diets compared to controls. These genes were associated with infection and inflammation. Transcription factors and miRNAs were identified as potential regulators of the dietary genes. Interestingly, caspase 1 and sialophorin are differentially expressed in the opposite direction after the intake of supplements compared to Alzheimer’s disease patients. In addition, ten transcription factors were identified that regulated gene expression in supplemented diets, mild cognitive impairment, and Alzheimer’s disease. Conclusions: We identified genes whose expression is altered after the intake of the supplements as well as the transcription factors and miRNAs involved in their regulation. These genes are associated with schizophrenia, neoplasms, and rheumatic arthritis, suggesting that the Mediterranean diet may be beneficial in reducing these diseases. In addition, the results suggest that the Mediterranean diet may also be beneficial in reducing the risk of dementia.
Exploring Attitudes, Subjective Norms and Perceived Behavioural Control in a Genetic-Based and a Population-Based Weight Management Intervention: A One-Year Randomized Controlled Trial
Authors: Horne Justine R. , Gilliland Jason A. , Vohl Marie-Claude , Madill Janet
Published: December 2020

Background: Several studies demonstrate that the provision of personalized lifestyle advice, based on genetics, can help motivate individuals to engage in greater nutrition and physical activity changes compared to the provision of population-based advice. The theoretical mechanism behind this phenomenon is poorly understood. The objective of this study was to determine the impact of providing genetically tailored and population-based lifestyle advice on key constructs of the Theory of Planned Behaviour (TPB). Materials and Methods: A pragmatic, cluster randomized controlled trial (n = 140) took place at the East Elgin Family Health Team, in Aylmer, Ontario, Canada. Participants were primarily Caucasian females enrolled in a weight management program (BMI ≥ 25.0 kg/m2). Weight management program groups were randomized (1:1) to receive a population-based lifestyle intervention for weight management (Group Lifestyle Balance™ (GLB)) or a lifestyle genomics (LGx)-based lifestyle intervention for weight management (GLB+LGx). Attitudes, subjective norms and perceived behavioural control were measured at baseline, immediately after receiving a report of population-based or genetic-based recommendations and after 3-, 6- and 12-month follow-ups. Linear mixed models were conducted, controlling for measures of actual behavioural control. All analyses were intention-to-treat by originally assigned groups. Results: Significant changes (p < 0.05) in attitudes, subjective norms, and perceived behavioural control tended to be short-term in the GLB group and long-term for the GLB+LGx group. Short-term and long-term between-group differences in measures of subjective norms were discovered, favouring the GLB+LGx group. Conclusions: The TPB can help provide a theoretical explanation for studies demonstrating enhanced behaviour change with genetic-based lifestyle interventions. Clinical Trial Registration: NCT03015012.