bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying subtypes of bipolar disorder based on clinical and neurobiological characteristics
Authors: Chen Yen-Ling , Tu Pei-Chi , Huang Tzu-Hsuan , Bai Ya-Mei , Su Tung-Ping , Chen Mu-Hong , Wu Yu-Te
Published: August 2021

The ability to classify patients with bipolar disorder (BD) is restricted by their heterogeneity, which limits the understanding of their neuropathology. Therefore, we aimed to investigate clinically discernible and neurobiologically distinguishable BD subtypes. T1-weighted and resting-state functional magnetic resonance images of 112 patients with BD were obtained, and patients were segregated according to diagnostic subtype (i.e., types I and II) and clinical patterns, including the number of episodes and hospitalizations and history of suicide and psychosis. For each clinical pattern, fewer and more occurrences subgroups and types I and II were classified through nested cross-validation for robust performance, with minimum redundancy and maximum relevance, in feature selection. To assess the proportion of variance in cognitive performance explained by the neurobiological markers, multiple linear regression between verbal memory and the selected features was conducted. Satisfactory performance (mean accuracy, 73.60%) in classifying patients with a high or low number of episodes was attained through functional connectivity, mostly from default-mode and motor networks. Moreover, these neurobiological markers explained 62% of the variance in verbal memory. The number of episodes is a potentially critical aspect of the neuropathology of BD. Neurobiological markers can help identify BD neuroprogression.
Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions
Authors: Lushpa Vladislav A. , Goncharuk Marina V. , Lin Cong , Zalevsky Arthur O. , Talyzina Irina A. , Luginina Aleksandra P. , Vakhrameev Daniil D. , Shevtsov Mikhail B. , Goncharuk Sergey A. , Arseniev Alexander S. , Borshchevskiy Valentin I. , Wang Xiaohui , Mineev Konstantin S.
Published: August 2021

Toll-like receptors (TLRs) play an important role in the innate immune response. While a lot is known about the structures of their extracellular parts, many questions are still left unanswered, when the structural basis of TLR activation is analyzed for the TLR intracellular domains. Here we report the structure and dynamics of TLR1 toll-interleukin like (TIR) cytoplasmic domain in crystal and in solution. We found that the TLR1-TIR domain is capable of specific binding of Zn with nanomolar affinity. Interactions with Zn are mediated by cysteine residues 667 and 686 and C667 is essential for the Zn binding. Potential structures of the TLR1-TIR/Zn complex were predicted in silico. Using the functional assays for the heterodimeric TLR1/2 receptor, we found that both Zn addition and Zn depletion affect the activity of TLR1, and C667A mutation disrupts the receptor activity. Analysis of C667 position in the TLR1 structure and possible effects of C667A mutation, suggests that zinc-binding ability of TLR1-TIR domain is critical for the receptor activation.
The genome of the thin-necked bladder worm Taenia hydatigena reveals evolutionary strategies for helminth survival
Authors: Wang Shuai , Liu Xiaolin , Liu Zhongli , Wang Yugui , Guo Aijiang , Huang Wanlong , Wang Qianhao , Zhang Shaohua , Zhu Guan , Luo Xuenong , Zhu Xing-quan , Cai Xuepeng
Published: August 2021

Taenia hydatigena is a widespread gastrointestinal helminth that causes significant health problems in livestock industry. This parasite can survive in a remarkably wide range of intermediate hosts and affects the transmission dynamics of zoonotic parasites. T. hydatigena is therefore of particular interest to researchers interested in studying zoonotic diseases and the evolutionary strategies of parasites. Herein we report a high-quality draft genome for this tapeworm, characterized by some hallmarks (e.g., expanded genome size, wide integrations of viral-like sequences and extensive alternative splicing during development), and specialized adaptations related to its parasitic fitness (e.g., adaptive evolutions for teguments and lipid metabolism). Importantly, in contrast with the evolutionarily close trematodes, which achieve gene diversification associated with immunosuppression by gene family expansions, in T. hydatigena and other cestodes, this is accomplished by alternative splicing and gene loss. This indicates that these two classes have evolved different mechanisms for survival. In addition, molecular targets for diagnosis and intervention were identified to facilitate the development of control interventions. Overall, this work uncovers new strategies by which helminths evolved to interact with their hosts.
A Co-intercalation enhanced V-based cathode material for fast charge aqueous zinc ion batteries
Authors: Zhang Shangshang , Liu Zhenjiang , Li Lun , Li Shengkai , Zhang Shuqi , Tang Yudie , Yu Jiale , Zhang Haiyan
Published: August 2021

H2O–H–Na co-intercalation V-base material exhibited an excellent fast charging and Zn2+ storage performance with the reversible phase transformed.
Screening of dicyanoisophorone-based probes for highly sensitive detection of viscosity changes in living cells and zebrafish
Authors: Kong Fanpeng , Li Ying , Li Xiao , Wang Xiaoxiu , Fu Guanyu , Zhao Qiuyue , Tang Bo
Published: August 2021

Screening results indicated that DCO-5 exhibited the highest sensitivity to viscosity and was insensitive to polarity or pH, and enables the successful detection of viscosity changes in vivo.
Stimuli-responsive polypeptides for controlled drug delivery
Authors: Zhang Peng , Li Mingqian , Xiao Chunsheng , Chen Xuesi
Published: August 2021

We summarize the advances of polypeptide-based drug delivery systems that respond to various physiological stimuli for controlled drug delivery applications.
Linkage-selective derivatization for glycosylation site- and glycoform-specific characterization of sialic acid isomers using mass spectrometry
Authors: Peng Ye , Gu Bing , Sun Zhenyu , Li Yueyue , Zhang Ying , Lu Haojie
Published: August 2021

A linkage-selective stable isotope labelling approach for the MS-based differentiation and relative quantification of sialyl-linkage isomers of N-glycopeptide is reported.
New horizons in low oxidation state group 2 metal chemistry
Authors: Rösch Bastian , Harder Sjoerd
Published: August 2021

Although the chemistry of the group 2 metals has always been dominated by their +II oxidation state, there is an increasing interest in their low-valent complexes. Recent developments include zero-valent complexes and observation of N2 fixation.
Control of location and distribution of heteroatoms substituted isomorphously in framework of zeolites and zeotype materials
Authors: Yabushita Mizuho , Osuga Ryota , Muramatsu Atsushi
Published: August 2021

Well-controlled incorporation of heteroatoms in frameworks of zeolites and zeotype materials has been achieved by a variety of new synthetic approaches, generating outstanding catalysts compared to uncontrolled materials.
Two pairs of chiral lanthanide–oxo clusters Ln14 induced by amino acid derivatives
Authors: Lu Tian-Qi , Yin Jia-Jia , Chen Cheng , Shi Hai-Yan , Zheng Jun , Liu Zhengjie , Fang Xiaolong , Zheng Xiu-Ying
Published: August 2021

Two pairs of chiral lanthanide–oxo clusters l-/d-Ln14 (Ln = Y/Dy) have been obtained under the action of anion template. The solid-state circular dichroism (CD) spectra of l-Y14/d-Y14 and l-Dy14/d-Dy14 displayed mirror symmetry effects.
A combined experimental and theoretical investigation of the excited-state dynamics of 2,4,6-trinitrotoluene (TNT) in DMSO solvent
Authors: Liu Runze , Shang Fangjian , Xiong Ying , Zhang Chaoyang , Yang Songqiu , Zhou Panwang , Liu Jianyong
Published: August 2021

In the present contribution we carried out a TDDFT and femtosecond transient absorption study of the excited state dynamics of TNT in DMSO solvent.
Structure and solvation dynamics of the hydroxide ion in ice-like water clusters: a CCSD(T) and car–parrinello molecular dynamics study
Authors: Lemke Kono H.
Published: August 2021

Electronic structure theory and CPMD simulations are employed to investigate the structure, solvation dynamics and vibrational spectra of OH−(H2O)n.
Surface-enhanced Raman scattering in ETPTA inverse photonic crystals with gold nanoparticles
Authors: Ashurov Matin , Abdusatorov Bakhodur , Baranchikov Alexander , Klimonsky Sergey
Published: August 2021

The detection limit of methylene blue of about 10−7 M was achieved by measuring Raman scattering of light at a laser wavelength that coincides with the photonic stop band of a composite substrate consisting of inverse opal with gold nanoparticles.
A novel sensitive ACNTs–MoO2 SERS substrate boosted by synergistic enhancement effect
Authors: Zhou Xiaoyu , Zhao Xiaoli , Gu Shuo , Gao Kaiyue , Xie Fazhi , Wang Xiufang , Tang Zhi
Published: August 2021

The bead chain acidified carbon nanotubes MoO2 prepared by two-step hydrothermal synthesis method had significant SERS performance, due to the synergistic effect of chemical and electromagnetic enhancement.
Modeling magnetic interactions in high-valent trinuclear [Mn3(IV)O4]4+ complexes through highly compressed multi-configurational wave functions
Authors: Li Manni Giovanni
Published: August 2021

In this work we apply a novel quantum chemical framework to rationalize the low-energy electronic spectrum and the magnetic properties of an homo-valent trinuclear [Mn3(IV)O4]4+ model of the oxygen-evolving center in photosystem II.
NMR studies of group 8 metallodrugs:187Os-enriched organo-osmium half-sandwich anticancer complex
Authors: Needham Russell J. , Prokes Ivan , Habtemariam Abraha , Romero-Canelón Isolda , Clarkson Guy J. , Sadler Peter J.
Published: August 2021

Synthesis of this187Os-enriched organo-osmium azopyridine anticancer complex, has allowed determination of187Os NMR J-couplings to ligand1H and13C, and the187Os chemical shift. The complex was also characterised by X-ray crystallography and MS.
Anion recognition by halogen bonding and hydrogen bonding bis(triazole)-imidazolium [2]rotaxanes
Authors: Turner Grace , Docker Andrew , Beer Paul D.
Published: August 2021

A novel halogen bonding bis(iodotriazole)-imidazolium axle containing [2]rotaxane is capable of strong halide and sulfate binding in highly competitive aqueous–organic solvent mixtures.
Optimal energy storage portfolio for high and ultrahigh carbon-free and renewable power systems
Authors: Guerra Omar J. , Eichman Joshua , Denholm Paul
Published: August 2021

We developed a high-temporal and high-spatial resolution grid planning framework to simultaneously assess the variable renewable power deployment and the optimal storage portfolio for seven independent system operators in the United States.
Black rice anthocyanins alleviate hyperlipidemia, liver steatosis and insulin resistance by regulating lipid metabolism and gut microbiota in obese mice
Authors: Song Haizhao , Shen Xinchun , Zhou Yang , Zheng Xiaodong
Published: August 2021

Supplementation of black rice anthocyanins (BRAN) alleviated high fat diet-induced obesity, insulin resistance and hepatic steatosis by improvement of lipid metabolism and modification of the gut microbiota.
Elucidating metal ion-regulated flavour formation mechanism in the aging process of Chinese distilled spirits (Baijiu) by electrochemistry, ICP-MS/OES, and UPLC-Q-Orbitrap-MS/MS
Authors: Zheng Qing , Hu Yaru , Xiong Ayuan , Su Ying , Wang Zihao , Zhao Kun , Yu Yougui
Published: August 2021

Schematic representation of the metal ion-regulated flavour formation mechanism in the aging process of Baijiu.
Uncovering the active sites and demonstrating stable catalyst for the cost-effective conversion of ethanol to 1-butanol
Authors: Guo Mond F. , Gray Michel J. , Job Heather , Alvarez-Vasco Carlos , Subramaniam Senthil , Zhang Xiao , Kovarik Libor , Murugesan Vijayakumar , Phillips Steven , Ramasamy Karthikeyan K.
Published: August 2021

The emergence of a renewable ethanol industry has provided a sustainable platform molecule to produce value-added chemicals and fuels; what is lacking now are viable conversion processes from ethanol that can displace non-renewable pathways.
Methanol economy and net zero emissions: critical analysis of catalytic processes, reactors and technologies
Authors: Mondal Ujjal , Yadav Ganapati D.
Published: August 2021

The overuse of fossil fuels has led to the disruption of the balance of the carbon cycle: the transportation and electricity generation sectors are the greatest contributors. The methanol economy can replace the fossil fuel economy using CO2and green hydrogen as sources.
Hydrothermal amination of biomass to nitrogenous chemicals
Authors: Wu Hongguo , Li Hu , Fang Zhen
Published: August 2021

This review presents the conversion routes, processing strategies, state-of-the-art technical advances, challenges and perspectives in hydrothermal amination of N-rich biomass sources and N-free biomass feedstocks to nitrogenous chemicals.
Lignin amination valorization: heterogeneous catalytic synthesis of aniline and benzylamine from lignin-derived chemicals
Authors: Rong Yue , Ji Na , Yu Zhihao , Diao Xinyong , Li Hanyang , Lei Yaxuan , Lu Xuebin , Fukuoka Atsushi
Published: August 2021

Using lignin derivatives as substrates, important organic nitrogen chemicals such as aniline and benzylamine can be obtained with high selectivity through heterogeneous catalyzed amination.
In the search for ditriel B⋯Al non-covalent bonding
Authors: Berski Slawomir , Gordon Agnieszka J.
Published: August 2021

The ditriel B⋯Al interaction has been characterised using SAPT, AIM and ELF.
Combining 1,2,4-triazole and pyrazole frameworks for new insensitive energetic materials
Authors: Dai Changhao , Chen Jieyi , Tang Jie , Cheng Guangbin , Yang Hongwei
Published: August 2021

A new symmetric compound 3,5-bis(3-amine-4H-1,2,4-triazole)-1H-pyrazole and a series of corresponding energetic cationic salts were synthesized.
How size, shape and assembly of magnetic nanoparticles give rise to different hyperthermia scenarios
Authors: Gavilán H. , Simeonidis K. , Myrovali E. , Mazarío E. , Chubykalo-Fesenko O. , Chantrell R. , Balcells Ll. , Angelakeris M. , Morales M. P. , Serantes D.
Published: August 2021

We demonstrate that some assemblies of anisometric nanoparticles could be the ideal agents to optimize the response to external AC fields for magnetic fluid hyperthermia in viscous environments.
Macroscopical monolayer films of ordered arrays of gold nanoparticles as SERS substrates for in situ quantitative detection in aqueous solutions
Authors: Xing Lixiang , Wang Cui , Cao Yi , Zhang Jihui , Xia Haibing
Published: August 2021

In situ SERS quantitative detection without internal standard molecules is achieved by macroscopical monolayer films of ordered arrays of gold nanoparticles.
“Turning the dials”: controlling synthesis, structure, composition, and surface chemistry to tailor silicon nanoparticle properties
Authors: Milliken Sarah , Thiessen Alyxandra N. , Cheong I Teng , O'Connor Kevin M. , Li Ziqi , Hooper Riley W. , Robidillo Christopher Jay T. , Veinot Jonathan G. C.
Published: August 2021

Exploring the various methods for affording tunable material properties in silicon nanoparticles.
Electrokinetics of polymeric fluids in narrow rectangular confinements
Authors: Natu Aditya , Ghosh Uddipta
Published: August 2021

The flow of polymeric liquids in narrow confinements with a rectangular cross section, in the presence of electrical double layers is analyzed here.
Enhanced Immune Response by Vacuoles isolated from Saccharomyces cerevisiae in RAW 264.7 Macrophages
Authors: Lee Su-Min , Choi Wooil , Shin Woo-Ri , Kim Yang-Hoon , Min Jiho
Published: August 2021

Vacuoles are membrane vesicles in eukaryotic cells, the digestive system of cells that break down substances absorbed outside the cell and digest the useless components of the cell itself. Researches on anti-cancer and intractable diseases using vacuoles are being actively conducted. The practical application of this study to animals requires the determination of the biocompatibility of vacuole. In the present study, we evaluated the effects of vacuoles isolated from S. cerevisiae in RAW264.7 cells. This showed a significant increase in the production of nitric oxide produced by macrophage activity. Using Reactive Oxygen Species (ROS) Assay, we identified that ROS is increased in a manner dependent on vacuole concentration. Western blot analysis showed that vacuole concentration-dependently increased protein levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2). Therefore, iNOS expression was stimulated to induce Nitric oxide (NO) production. In addition, pro-inflammatory cytokines levels promoted, such as interleukin 6 and tumor necrosis factor -α. In summary, vacuoles activate the immune response of macrophages by promoting the production of immune-mediated transporters NO, ROS, and pro-inflammatory cytokines.
Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress
Authors: Fouda Sherouk , Khan Anwar , Chan Stanley M.H. , Mahzari Ali , Zhou Xiu , Qin Cheng Xue , Vlahos Ross , Ye Ji-Ming
Published: August 2021

Consumption of diet rich in fat and cigarette smoking (CS) are independent risk factors of non-alcoholic steatohepatitis (NASH), and they often occur together in some populations. The present study investigated the mechanisms of high-fat diet (HFD) and CS, individually and in combination, on the pathogenesis of NASH in mice. C57BL/6 male mice were subjected to either a low-fat chow (CH) or HFD with or without mainstream CS-exposure (4 cigarettes/day, 5 days/ week for 14 weeks). HFD alone caused hepatosteatosis (2.5-fold increase in TG content) and a significant increase in 3-nitrotyrisine (by ∼40-fold) but without an indication of liver injury, inflammation or fibrosis. CS alone in CH-fed mice increased in Tnfα expression and macrophage infiltration by 2-fold and relatively less increase in 3-nitrotyrosine (18-fold). Combination of HFD and CS precipitated hepatosteatosis to NASH reflected by exacerbated makers of liver inflammation and fibrosis which were associated with much severe liver oxidative stress (90-fold increase in 3-nitrotyrisine along with 6-fold increase in carbonylated proteins and 56% increase in lipid oxidations). Further studies were performed to administer the antioxidant tempol to CS exposed HFD mice and the results showed that the inhibition of liver oxidative stress prevented inflammatory and fibrotic changes in liver despite persisting hepatosteatosis. Our findings suggest that oxidative stress is a key mechanism underlying CS-promoted progression of simple hepatosteatosis to NASH. Targeting hepatic oxidative stress may be a viable strategy in halting the progression of metabolic associated fatty liver disease.
Model‐free linear active disturbance rejection output feedback control for electro‐hydraulic proportional system with unknown dead‐zone
Authors: Wang Lixin , Zhao Dingxuan , Zhang Zhuxin , Liu Qian , Liu Fucai , Jia Tuo
Published: August 2021

Here, a model‐free linear active disturbance rejection controller (LADRC) integrating dead‐zone inverse compensation for an electro‐hydraulic proportional (EHP) system with an unknown dead‐zone is proposed. Unlike the existing LADRC design idea, the presented method uses a new hydraulic system block diagram to select the order of LADRC instead of the highest degree of the system. Furthermore, the rationality of order selection is illustrated by the frequency domain analysis theory. To solve the dead‐zone of the proportional valve, a novel structural transformation is proposed by constructing a new dead‐zone, which has a definite physical meaning and can be obtained by the experimental measurement. Then, the dead‐zone disturbance is reduced, and the burden of the observer is relieved. At the same time, the controller parameters are decreased from three to two equivalent PI controller. Besides, the stability of the closed‐loop system is analysed by the describing function method. The performance of the proposed control solution has been investigated through extensive comparative experiments under different working conditions. The experimental results successfully demonstrate the effectiveness and practicality of the presented method.
All‐factor short‐term photovoltaic output power forecast
Authors: Zhang Na , Wang Shouxiang , Liu Guang‐Chen , Zhang Jian‐Wei
Published: August 2021

Accurately predicting photovoltaic output power is one of the most important basic tasks for the rapid development of the smart grid. The factors that influence photovoltaic output power are not fully considered in the current forecast model. To this end, an all‐factor photovoltaic short‐term output power prediction model based on improved ensemble empirical mode decomposition (EEMD) and the seeker optimization algorithm (SOA) ‐BP neural network model is proposed here. First, different similarity algorithms are used in the selection of similar days of different weather types. Second, the factors that affect the PV output power are divided into deterministic parameters and stochastic parameters. The stochastic parameters of similar daily samples are used to constitute a time series, which is decomposed into several stationary signals by EEMD, and then, these signals are trained separately by the SOA‐BPNN model. Finally, the final forecast result can be synthesized with the deterministic parameters and the accumulation of the predicted data of individual signals. Compared with the results of different prediction models, the prediction accuracy of the proposed model is much higher.
Cluster division in wind farm through ensemble modelling
Authors: Wang Yue , Li Yong‐Gang , Xie Huiyang , Wu Bin‐Yuan , Yang Yi‐Nan
Published: August 2021

To increase the equivalence accuracy of wind farms and expand their applicability under multiple operating conditions, this paper proposes a method combining blending with extreme gradient boosting (XGBoost) to realize clustering index dimensionality reduction and dynamic time warping (DTW) optimization. Density‐based spatial clustering of applications with noise (DBSCAN) is aimed at realizing clustering and fusing the clustering results. This approach can help process multi‐dimensional time‐series feature operation data of wind turbines to formulate accurate and effective wind farm plans for the division of wind turbine clusters onsite. First, the XGBoost‐Blending approach is used to select the clustering indicators for dimensionality reduction. Second, a clustering method based on DBSCAN‐DTW is established to divide the clusters and perform ensemble clustering. Finally, MATLAB/Simulink is used to build a simulation model. In this manner, a three‐phase short‐circuit is introduced at the grid‐connection point of a wind farm. A case study is performed under a variety of wind speed scenarios. The results verify the accuracy and wide applicability of the equivalence model formulated using the proposed method.
A hybrid approach to investigate the relationship between design factors and sustainability
Authors: Mohagheghian Elahe , Hosseini-Nasab Hasan , Zare-Mehrjerdi Yahia , Fakhrzad Mohammad-Bagher
Published: August 2021

Factors considered in product design have a significant impact on future cost and sustainability. Some factors such as materials, dimensions, and tolerances are crucial in the design process of many products. At the macro scale, this can give rise to environmental effects and influence the reliability and sustainability of the product. In this research, a hybrid system dynamics simulation-optimization approach has been proposed for tolerance design. In this approach, first, the optimal values of tolerance and price are determined by conjoint analysis. These values are entered into a system dynamics model to evaluate the relationships among sustainability, reliability, and customer satisfaction. Then, the impact of tolerance and other factors of product design on sustainability, reliability, and customer satisfaction are investigated. This approach can help decision-makers better understand the trade-off between design factors, resilience, sustainability, and customer satisfaction and make more informed decisions. The proposed method is illustrated for computer assembly step by step. The results show that lower sustainability and higher customer satisfaction are directly associated with tighter tolerances. Besides, lower sustainability, higher reliability, and higher customer satisfaction are associated with lower quality of materials. The validity of the model was examined using a boundary-adequacy test.
Netnography: towards a new sociological approach of qualitative research in the digital age
Authors: Kaoukaou Mahjouba
Published: August 2021

This paper tackles the question ofnetnographyin the digital age. The shifts that the world has known during these last decades lead to the emergence of a new paradigm. The research in digital studies raises today many issues about the notions and the methods that we should use in this new field of study. We aim from our research to contribute to this current scientific discussion through a main question that we intend to address in our paper, and which we can formulate as follows: what is the nature of the criteria and the characteristics which make netnography a different method than ethnography? And if the subject of study in this practice is virtual and geographically undetermined, how can the researcher limit it, and how can he address it scientifically? Our goal from this paper is to unveil the specificity of netnography as a new notion and a new practice in sociology. So, we will formulate our perception of this concept by demarcating the lines between it and the other notions which intersect with it, namely, ethnography.
Sexual and reproductive health as a research topic, which acceptability among Moroccan youth?
Authors: El Hassouni Jamila , Rouahi Nabila , Senhaji Meftaha
Published: August 2021

As a previous step of a quantitative study about sexual and reproductive health (SRH) among young Moroccan adults, and because of the sensitivity of this field, we aimed to examine its feasibility and acceptability through a qualitative approach. We conducted four focus groups composed of 26 participants from both sexes and aged from 18 to 23 years old, studying at the Higher Institute of Nursing Professions and Health Techniques of Tetouan. We carried out the coding and categorizing the verbatim transcripts using the QRS Nvivo v.10.0. The results show that the majority of participants do not know the concept of SRH except for some components such as HIV/AIDS and family planning and that the Internet is their leading source of information. They also show the influence of social norms and religion on sexual practices among female participants, whereas sexuality was the main concern of male participants. Therefore, sex and education seem to be the best way to solve SRH related problems. In fact, participants insisted on its integration into the basic school curriculum. They also expressed their need for an official website about SRH managed by experts as well as a health service specialized in SRH, both specific to adolescents and youth. We conclude that a quantitative study on this topic is feasible and acceptable in our context.
Proposal of a research design for the implementation of new vectors of supply chain transformation: application to the aeronautical industry in Morocco using a knowledge management approach in an ecosystemic context
Authors: Ettaibi Mohamed , Bouchaib Mokhtari
Published: August 2021

In the context of the new economy, the new vectors of competitiveness of companies in the aerospace industry organized within efficient ecosystems (EFECO) will be based more on knowledge. These are Industry 4.0 and the decarbonization of production based on knowledge management (KM). These two levers will be the foundations of the transformation of the aeronautical supply chain in the future. For their implementation, we made a case study on a non-probability sample of 17 partners. At the end of this investigation, we propose implementing a new generation of transversal ecosystems within the framework of a new Industrial Acceleration Plan 2.0. This new form of organization will facilitate a collaborative sharing of knowledge between all the ecosystemic components with a view to innovation. Starting from the Industrial Acceleration Plan ( IAP) (2014-2020), we will make our proposal based on a knowledge management approach. In this context, our epistemological posture will be interpretative with a constructivism arranged. Our methodological approach will be qualitative. Our study will be in line with a perspective of proactivity and supposition.
Evaluation antioxidant activity and corrosion inhibition of C38 in Hydrochloric acid medium by dried lemon peels of Kenitra Marrakech cities in Morocco and Taiz town in Yemen: A Comparative study
Authors: Abdu Khaled , Erahioui Rahma , Khedid Khadija , deen Hefdhal , Elhawary Maha , Laqh Abdallah , El Hamidi Adnane , Zahidi Ahmed , Al emad Ali , Ibn Ahmed Said
Published: August 2021

This paper presents a comparative study about the evaluation of antioxidant activity and corrosion inhibition in Kenitra, Marrakesh and Taiz. An interesting topic, indeed polyphenols can improve or help to reduce oxidative stress in the treatment of digestive problems, weight management difficulties, diabetes, hypertension, arteriosclerosis and damage fatty tissue. Therefore, the authors deal with the measurement of polyphenol content and evaluation of the antioxidant activity of lemon peels in Kenitra , Marrakesh and Taiz.The authors performs empirical analyzes on lemon peels. The total polyphenol contents of the ethanolic extract of lemon peels were measured. It was to be 30. 23, 26. 346 and 20.961 mg/CE/g in Kenitra, Marrakech, and Taiz, respectively. Moreover, the DPPH radical scavenging activity of ethanolic extract of dried lemon peels was higher than 200μg/ml concentration. They were 73.47%, 47.36%, and 32.09in Kenitra, Marrakech, and Taiz, respectively. Also, the IC50 values of ethanolic extracts calculated from the percentage inhibitions at the same concentration. Inhibition (IC50) which obtained in Kenitra was 123.089 μg/ml. It was lower compared to the ethanol extract of Marrakech and Taiz that were 197.418, 276.750μg/mL, respectively. Therefore, the extract which is containing a high amount of phenolic is showed high radical scavenging activity. In addition, the maximum inhibition efficiencies for 2 mL L-1 of the inhibitor at 298 k were 98, 12% and 84, 85 % in Kenitra and Taiz, respectively. These values obtained through polarization curve measurements.
Evaluation of the landslide susceptibility map obtained by a GIS matrix method: a case of Al Hoceima city (northern Morocco)
Authors: Byou Taoufik
Published: August 2021

This work presents a method for preparing landslide susceptibility maps based on an analysis between past movements and predisposing factors. The proposed methodology for determining susceptibility is an adaptation of the matrix method in the territory of the city of Al Hoceima (Northern Morocco). The data needed to evaluate vulnerability has based on the landslide inventory and the available cartographic documents. These data were prepared and integrated into a GIS. This phase of the data preparation has followed by assessment and susceptibility mapping. The obtained map was validated and compared with an independent landslide dataset than the one used to develop the model. The results of the ROC (receiver operating characteristic) curve demonstrate the good predictive ability (AUC = 0.94). We can deduce that the map correlates well with the existing terrain conditions. The successfully validated prediction will enable decision-makers to offer handy information for infrastructure construction and urban planning in the future or other areas with similar situations
Serious Games at the service of student’s integration into the work sector: Case of computer science engineering students
Authors: Sabri Zineb , Moumen Aniss , Fakhri Youssef
Published: August 2021

Students develop a big commitment personally and invest financially to pursue their education and get the degree that opens many gateways for them, but what if the degrees don’t match the skills required by most employers? As time has changed, employability is based on knowledge and several abilities such as soft skills, communication, leadership, creative and critical thinking. It is hard for universities to keep track of all these changes and, at the same time, the technological advancements, the hard facts and the skills of most of the disciplines. Our research aims to study the needs requested the most by employers. To achieve that, we started with a survey with some laureates and multiple interviews with different recruiters to identify their requirements. We can define the training students need to have before integrating the job market, ease their insertion, and make their integration successful.
The economic activities of sub-Saharan immigrants: informal sector and low wages
Authors: Jabrane Mourad , Idali Mouhsine , Madi Redouane
Published: August 2021

Immigration is a social phenomenon that leads to the immigrant’s sociological and economic reorganization, the immigrant often finds himself obliged to overcome the challenges of the economic integration into the host society. So, this study is an analysis of the economic activities of 102 sub-Saharan immigrants who live and work in the urban space of Rabat, and one semi-structured questionnaire is used to explores the specificities of the sectors of their economic activities. The results obtained confirm the findings of various authors affirming the recourse of immigrants to informal economic activity sectors generating low wages.
Sequential analysis as a method for studying life courses: The Case of caregivers’ well-being trajectories, Tiznit Morocco
Authors: Elbouzidi Mohamed , Mahdane Mhamed
Published: August 2021

Being a caregiver offers a sense of usefulness and satisfaction. Similarly, this caregiving function hurts all areas of the caregiver's life. In this vein, we believe that approaching this topic based on the sequential approach is of great importance.

Indeed, we will first present the life-course approach as a method for analysing longitudinal quantitative data while highlighting the different stages of sequence analysis as an appropriate analysis method. We will then discuss the importance of studying the life trajectories of caregivers as units of research in the life course approach.

The empirical demonstration of this paper originates from doctoral research in sociology on the life course of informal caregivers in the province of Tiznit in Morocco. Through this demonstration, we have crossed quantitative and qualitative analyses of life courses. This work will also show the relevance of sequence analysis and its adaptation to the life course approach of caregivers.
Pregnancy morbidity: Situation and determinants in the province of Essaouira - Morocco-
Authors: Manoussi Abdelmounaim , Baali Abdellatif , Amor Hakima , Ouzennou Nadia
Published: August 2021

Pregnancy-related morbidity is a public health problem. The main aim of this study is to assess the prevalence of maternal morbidity among childbearing women in Essaouira province (Morocco) and to determine the associated factors. A cross-sectional descriptive and analytical study conducted by questionnaire, surveyed 1184 married women aged between 18 to 49 years. The prevalence of pregnancies morbidity is 55.9% (662/1184). The mains determinants identified is sexually transmitted infections (STIs) with 50.1% and anaemia with 45.8%. Also, based on the multinomial logistic regression model, the socio-economic level, antenatal care regularity and precocity, pregnancies risks knowledge, distance from health care facilities and place of residence determine the pregnancies morbidity independently. In conclusion, Morocco must address family living conditions, health education, literacy, and other social determinants of health.
Digital accessibility: A systematic Literature Review
Authors: Chadli Fatima Ezzahra , Gretete Driss , Moumen Aniss
Published: August 2021

Today digital content has soared since the covid19 pandemic, no physical interaction, only digital operations, even in the education system and training. Learning moved towards the virtual classroom, and e-learning is now widely adopted. This transformation was a challenge for most people, especially people with disabilities. Although, despite the type of disability, digital content and services should be accessible, which means it includes considerations like compatibility with assistive technologies, using enough contrast for visually impaired users, providing understandable content, etc. Many studies have shown decades before covid19 the importance of digital accessibility, including guidelines, implementation and evaluation, design and methods. This systematic literature review of 204 studies exposes the different topics related to digital accessibility in previous studies.
Opportunities for development of dynamic web interfaces in an information system for research projects
Authors: Milev Plamen
Published: August 2021

The article examines issues, related to the development of software solutions for project management. In this sense, the paper presents features of an information system for research projects. The realization of a dynamism of some of the user interfaces is a relevant issue for these software solutions. The main purpose of the article is to explore the opportunities for realization of such behavior and to present the relevant models for development of dynamic web interfaces in the information system through server-side implementation. To achieve its goal, the article uses various scientific methods, including study, analysis, research, modeling and experimentation. The results support the main hypothesis of the study, namely defining the benefits of development of dynamic web interfaces using server-side implementation. The conclusion highlights the opportunities for improvement of user experience in the information systems in the subject area through the application of the researched approach.
Impact of marketing communication mix on business results of SMEs
Authors: Todorova Gergana , Zhelyazkov Georgi
Published: August 2021

Marketing communications show a favorable impact on all aspects of the company’s activities. They play an essential role in shaping the final economic results. The purpose of the research is to study the effects of elements for marketing communication mix on the business results of selected small and medium enterprises in Stara Zagora district, Bulgaria. The collection of primary data has been developed and disseminated to the owners/managers of SME’s survey. The research uses a descriptive and casual research approach to identify the impact of individual communication elements - advertising, sales promotion, and direct marketing on some financial parameters, such as the profit, sales, and profitability of the companies. The result shows statistical significance between advertising, sales promotion, and financial indicators: profit and net sales revenue. Recommendations were made to the SME managers regarding the use of promotional activities, using communication channels to inform and keep up to date customers, the effectiveness of the types of media, and more.
Gamification as the human resources management tool
Authors: Kanivets Valeria , Beliaeva Yulia
Published: August 2021

There is a huge number of different methods created to increase employee motivation, while they are constantly being improved and new ones appear. The manager must not only choose the right one, but also be able to implement it. One of the methods is gamification. The basics of HR management processes using this method are just beginning to form, so it is necessary to develop mechanisms for implementing gamification in the organization. Based on the research, the main provisions aimed at including elements of gamification in the company and recommendations for their implementation are formulated. The purpose of the article is to study gamification in the organization’s personnel management in detail and to formulate practical recommendations for its application. The research used methods of the theoretical level, such as: study and generalization, analysis and synthesis, deduction and induction, as well as the study of literature, the regulatory framework and other sources of information. On the basis of the study, the types of games and players, the main provisions aimed at including elements of gamification in the company, as well as recommendations for their implementation to improve the organization’s activities are formulated.
Sales policy: arrangement and controlling
Authors: Fatkullina Alina , Beliaeva Yulia
Published: August 2021

The article is devoted to the study of the commodity policy, which directly plays a key role in the management of any company, as well as affects all aspects of its activities. It examines the directions and goals of the product policy, studies its components and principles, as well as methods of managing the company’s product policy. The main idea is to reveal the essence of the product policy as an economically significant and effective tool for managing the company.
Internet marketing and e-commerce – interaction
Authors: Bilnikova Zvezdelina
Published: August 2021

E-commerce has taken up an increasing share of market relations in recent years. The use of online marketing tools allows us to reach the right end consumer. In the present report we shall study part of them and more specifically those used in communication policy. The main aim of this work is to analyze the interaction between internet marketing and e-commerce on the end consumer of goods and services. The research methods used are: theoretical and empirical methods, such as analysis, synthesis, comparison, etc. The results achieved are related to the analysis of establishing an internet shop or a website where the producer and the consumer of the good or the service meet. The conclusion generalizes on the use of social media, e-mail marketing, VibeMarket, online display ads as the main channels for internet advertising - a means through which the consumer may widen their selection options and receive detailed information about the saught product or service. Internet advertising brings benefits for advertisers because it needs a lower budget and is flexible when directed to a specific target group.
Agriculture in the context of rural development: South-Eastern planning region
Authors: Doitchinova Julia , Kanchev Ivan
Published: August 2021

For 15 years the agrarian business in our country has been developing in a business environment formed mainly by the common agricultural policy. The purpose of the report is to assess this development in the South-East Planning Region and its impacts on the socio-economic development of rural areas and the state of the environment. The report uses quantitative and qualitative methods. They are the basis of mixed research design. Of the quality methods, expert assessment based on a survey and in-depth structured interviews with 26 experts at the municipal and district level were applied. Quantitative methods are used to process survey and statistical information on agricultural and rural development in the Southeast planning region. The main results are related to the changes in the production and organizational structure of agriculture and their impact on jobs and employment, the age and qualification structure of the employed, unemployment, migration processes, etc. The characteristics of the applied model of agriculture in terms of the predominant type of farms, the functioning of producer organizations, the transition to the production of quality products with protected geographical indications, etc. are outlined.
Intelligent analysis of active management of animal husbandry
Authors: Dimitrov Stanislav , Stoilov Todor , Stoilova Krasimira
Published: August 2021

A quantitative analysis of the financial state of an animal husbandry is performed. The paper illustrates the usage of different economical parameters in order to present operational state of the husbandry and to search regularities for future actions. The added value of this research is the application of intelligent instruments in the management of the economic behavior of animal husbandry which give recommendations for their more effective functionality.
Competitive Advantages of the Bulgarian Wine Sector
Authors: Dimitrova Gergana
Published: August 2021

The wine industry is traditional sector in the Bulgarian economy. However, at the end of the XX century it faced various challenges. Later, it has started to restore and has developed in number of areas. Nowadays it has new characteristics, based on its strengths and weaknesses. Thus, the purpose of the current study is to identify the competitive advantages of the wine sector in Bulgaria. The object of the research are Bulgarian wine producers, who are small and middle size enterprises (SMEs). The focus of the study is a selection of indicators, which contribute for the identification of their competitive advantages. The data used is of own survey, performed among Bulgarian wine producers. The results show that the main advantages are targeted at qualitative wines from authentic local sorts. This justifies the obligatory direction for differentiation and validation of the Bulgarian wine producers by promoting the wines of local varieties and establishing the identity of the wine regions.
Classification of EU countries according to the degree of the sustainable development goals achievement related to agriculture
Authors: Nenova Radka
Published: August 2021

The main goal of the study is to classify the 27 countries of the European Union (excluding the UK) according to their contribution to achieving the UN’s global goals for sustainable development related to agriculture. Five goals were selected: Goal 2: Zero hunger, Goal 3: Good health and well-being, Goal 12: Responsible consumption and production, Goal 14: Life below water and Goal 15: Life on land. The following criteria for distinguishing countries were used in the clustering: Goal achievement, Challenges remain, Significant challenges, Major challenges. To achieve this goal, from a methodological point of view, are applied: correlation analysis, cluster analysis, ANOVA analysis of variance and post hog test for multiple comparison - Tukey HSD. As a result of the analysis, with data from the Sustainable Development Report 2020, four clusters were identified. Bulgaria falls into the second cluster, along with Croatia, Cyprus, Finland, France, Greece, Ireland and Sweden. The main conclusion for countries in the second cluster is that there are significant challenges for Goal 2 and Goal 14, challenges remain for Goal 3 and Goal 15 and major challenges for Goal 12.