bluuebunny/crossref_metadata_2025 huggingface dataset:
MOD-4023, a long-acting carboxy-terminal peptide-modified human growth hormone: results of a Phase 2 study in growth hormone-deficient adults
Authors: Strasburger Christian J , Vanuga Peter , Payer Juraj , Pfeifer Marija , Popovic Vera , Bajnok László , Góth Miklós , Olšovská Veˇra , Trejbalová L‘udmila , Vadasz Janos , Fima Eyal , Koren Ronit , Amitzi Leanne , Bidlingmaier Martin , Hershkovitz Oren , Hart Gili , Biller Beverly M K
Published: December 2016

Objective

Growth hormone (GH) replacement therapy currently requires daily injections, which may cause distress and low compliance. C-terminal peptide (CTP)-modified growth hormone (MOD-4023) is being developed as a once-weekly dosing regimen in patients with GH deficiency (GHD). This study’s objective is to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of MOD-4023 administered once-weekly in GHD adults.

Design

54 adults with GHD currently treated with daily GH were normalized and randomized into 4 weekly dosing cohorts of MOD-4023 at 18.5%, 37%, 55.5% or 123.4% of individual cumulative weekly molar hGH dose. The study included 2 stages: Stage A assessed the effectiveness and PK/PD profiles of the 4 dosing regimens of MOD-4023. Stage B was an extension period of once-weekly MOD-4023 administration (61.7% molar hGH content) to collect further safety data and confirm the results from Stage A.

Results

Dose-dependent response was observed for both PK and PD data of weekly MOD-4023 treatment. Insulin-like growth factor I (IGF-I) SDS levels were maintained within normal range. The 18.5% cohort was discontinued due to low efficacy. MOD-4023 was well tolerated and exhibited favorable safety profile in all dose cohorts. The reported adverse events were consistent with known GH-related side effects.

Conclusions

Once-weekly MOD-4023 administration in GHD adults was found to be clinically effective while maintaining a favorable safety profile and may obviate the need for daily injections. Weekly GH injections may improve compliance and overall outcome. The promising results achieved in this Phase 2 study led to a pivotal Phase 3 trial, which is currently ongoing.
Affective alterations in patients with Cushing’s syndrome in remission are associated with decreased BDNF and cortisone levels
Authors: Valassi E , Crespo I , Keevil B G , Aulinas A , Urgell E , Santos A , Trainer P J , Webb S M
Published: December 2016

Objective

Affective alterations and poorer quality of life often persist in patients with Cushing’s syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic–pituitary–adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were to assess affective alterations after long-term remission of CS and evaluate whether they are associated with serum BDNF, salivary cortisol (SalF) and/or cortisone (SalE) concentrations.

Subjects and methods

Thirty-six CS patients in remission (32 females/4 males; mean age (±s.d.), 48.8 ± 11.8 years; median duration of remission, 72 months) and 36 gender-, age- and BMI-matched controls were included. Beck Depression Inventory-II (BDI-II), Center for Epidemiological Studies Depression Scale (CES-D), Positive Affect Negative Affect Scale (PANAS), State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS) and EuroQoL and CushingQoL questionnaires were completed and measured to evaluate anxiety, depression, stress perception and quality of life (QoL) respectively. Salivary cortisol was measured using liquid chromatography/tandem mass spectrometry (LC/TMS). BDNF was measured in serum using an ELISA.

Results

Remitted CS patients showed worse scores in all questionnaires than controls: STAI (P< 0.001), BDI (P< 0.001), CES-D (P< 0.001), PANAS (P< 0.01), PSS (P< 0.01) and EuroQoL (P< 0.01). A decrease in BDNF was observed in CS vs controls (P= 0.038), and low BDNF was associated with more anxiety (r= −0.247,P= 0.037), depression (r= −0.249,P= 0.035), stress (r= −0.277,P= 0.019) and affective balance (r= 0.243,P= 0.04). Morning salivary cortisone was inversely associated with trait anxiety (r= −0.377,P= 0.040) and depressed affect (r= −0.392,P= 0.032) in CS patients. Delay to diagnosis was associated with depressive symptoms (BDI-II:r= 0.398,P= 0.036 and CES-D:r= 0.449,P= 0.017) and CushingQoL scoring (r= −0.460,P< 0.01).

Conclusions

Low BDNF levels are associated with affective alterations in ‘cured’ CS patients, including depression, anxiety and impaired stress perception. Elevated levels of SalE might also be related to poor affective status in these patients.
Continuity in the Kindergarten and Primary School in the Implementation of the Contents of Laying the Foundations of Individual Value Attitude to Their Own Health
Authors: Pyechka Larysa
Published: December 2016

In the article are highlighted the results of theoretical analysis of continuity in thekindergarten and primary school in the implementation of the contents of laying the foundationsof individual value attitude to their own health. Researcher reveals the pedagogical theories ofscientists to study the problem of succession. For depth scientific analysis and practicalimplementation of the process under study the emphasis is made on identifying scientific aspectsfor developing children's healthy lifestyle
Modern Scientific Research on the Development of Proactiveness of Preschool Children
Authors: Agiliar Tukler Victoria
Published: December 2016

This article introduces the results of analysis of modern scientific research in preschooleducation, which represents the problem of development of basic qualities of the identity. Theresearch displays that the results of the study on the problem of development of basic qualities ofpreschool-age children influence the improvement of the content of program provision in theeducational process in preschool educational institutions in Ukraine and are meant to be areference point in choosing the strategy of its reorganization
Education as a Genuine Social and Personal Value
Authors: Machynska Nataliya , Derkach Yuliya
Published: December 2016

Education is considered to play the role of social institution which transmits basiccultural values and goals of society. It helps to create new things not forgetting about the old ones.The process of education turns and directs the life of society, saving even of the smallest value tohumans. Education has the capacity to design individual skills and values, to increase the mobilityof the individual in society being the main source of forming a certain system of human values. Aperson who is able to live effectively and work in a global environment should be prepared byeducation. Education as a personal value is displayed through the implementation of tasks ofpatriotic education, which is important because of a sense of belonging to a nation and state. Inorder the education to become valuable for everybody, it is necessary it to give the key knowledge.To encourage a new generation of independent, individual learning, that will reflect in the desire todo something and to create something
"Crossroads" of Culture and Education as a Methodological Basis for Modern Pedagogy Content Formation
Authors: Smolinska Olesia , Dzyubynska Khrystyna
Published: December 2016

The article deals with various aspects of culture and education combination in order toseek methodological basis for the formation of new pedagogy content. Particularly, the followingaspects which combine culture and education are analyzed: ontological unity of man and society,the common evolution of culture and spirituality and, namely, the dialectical character ofconnection between phenomena of culture and education.The authors, who base on philosophical and pedagogical sources focus on the thesis about thenecessity of developing fundamental approaches to the development of educational content ingeneral. However, researchers consider the contradiction that exists between expediency of rapidcontents transformation and their culture stipulated gravitation - the key issue of the current stateof affairs. Authors find the solution to this problem in common conceptual and dynamiccharacteristics of culture and education, which form a specific unity - cultural and educationalspace. This phenomenon, in its turn, has the ability to generate culture appropriate contents of bothmodern education and pedagogy
Volunteer Activity in the Context of Formation of Social Intellect of Future Specialists in Social Work
Authors: Sokolova Tatsiana
Published: December 2016

The article describes such concepts as ”social intellect” and ”volunteer activity”; presentsapproaches to the definition of the phenomenon of volunteering. The author proves thepossibilities of volunteer activity in the context of formation of social intellect of future specialistsin social work, reveals the features of organization of students’ practical volunteer activity to formtheir social intellect
The Problem of Healthkeeping of Children and Youth in Polish Educational Thought at the XV- beginning of XX century
Authors: Slyvka Larysa
Published: December 2016

The article presents the results of educational research actions in preserving andpromoting the health of children and youth in the Polish educational theory and practice. Theauthor analyzes the progressive ideas in the field of health oriented educational technologieswhich dominated in Polish educational thought during XV ‒ beginning of XX centuries. Rethinkingof creative heritage of Polish scientists, educators and civic and educational leaders, opens up thenew approaches and opportunities in implementing pedagogical aspects of healthkeeping ofgrowing personality in Ukraine
Verbal Means of Persuasion in English Advertising
Authors: Karpenko Hanna
Published: December 2016

The article deals with verbal means of persuasion in English advertising. It investigatesmanipulation tactics and features of persuasion in the English ad. Linguistic and cultural aspects ofstyle formation in English and Ukrainian ads are compared in the article
Implementing Inclusive Education in Ukraine: Problems and Perspectives
Authors: Dubkovetska Iryna , Budnyk Olena , Sydoriv Sergiy
Published: December 2016

The article defines the essence of inclusive education and characterizes students withspecial needs. The status and problems of implementing inclusive education in Ukraine areanalyzed. The basic ethical principles of educational activities for pupils with special educationalneeds are defined. The authors set emphasis on the following issues: adaptation of the physicalenvironment for the proper functioning of persons with disabilities; overcoming stereotypes ofteaching professionals concerning psychological acceptance of inclusion; financing institutionswith planned implementation of inclusive education; developing special educational programs forschools with inclusive education and training of qualified professionals to work in inclusiveeducational environment
Population Genomics of Daphnia pulex
Authors: Lynch Michael , Gutenkunst Ryan , Ackerman Matthew , Spitze Ken , Ye Zhiqiang , Maruki Takahiro , Jia Zhiyuan
Published: December 2016

Using data from 83 isolates from a single population, the population genomics of the microcrustacean Daphnia pulex are described and compared to current knowledge for the only other well-studied invertebrate, Drosophila melanogaster. These two species are quite similar with respect to effective population sizes and mutation rates, although some features of recombination appear to be different, with linkage disequilibrium being elevated at short (<100 bp) distances in D. melanogaster and at long distances in D. pulex. The study population adheres closely to the expectations under Hardy–Weinberg equilibrium, and reflects a past population history of no more than a twofold range of variation in effective population size. Fourfold redundant silent sites and a restricted region of intronic sites appear to evolve in a nearly neutral fashion, providing a powerful tool for population genetic analyses. Amino acid replacement sites are predominantly under strong purifying selection, as are a large fraction of sites in UTRs and intergenic regions, but the majority of SNPs at such sites that rise to frequencies >0.05 appear to evolve in a nearly neutral fashion. All forms of genomic sites (including replacement sites within codons, and intergenic and UTR regions) appear to be experiencing an ∼2× higher level of selection scaled to the power of drift in D. melanogaster, but this may in part be a consequence of recent demographic changes. These results establish D. pulex as an excellent system for future work on the evolutionary genomics of natural populations.
Zinc Cluster Transcription Factors Alter Virulence in Candida albicans
Authors: Issi Luca , Farrer Rhys A , Pastor Kelly , Landry Benjamin , Delorey Toni , Bell George W , Thompson Dawn A , Cuomo Christina A , Rao Reeta P
Published: December 2016

Almost all humans are colonized with Candida albicans. However, in immunocompromised individuals, this benign commensal organism becomes a serious, life-threatening pathogen. Here, we describe and analyze the regulatory networks that modulate innate responses in the host niches. We identified Zcf15 and Zcf29, two Zinc Cluster transcription Factors (ZCF) that are required for C. albicans virulence. Previous sequence analysis of clinical C. albicans isolates from immunocompromised patients indicates that both ZCF genes diverged during clonal evolution. Using in vivo animal models, ex vivo cell culture methods, and in vitro sensitivity assays, we demonstrate that knockout mutants of both ZCF15 and ZCF29 are hypersensitive to reactive oxygen species (ROS), suggesting they help neutralize the host-derived ROS produced by phagocytes, as well as establish a sustained infection in vivo. Transcriptomic analysis of mutants under resting conditions where cells were not experiencing oxidative stress revealed a large network that control macro and micronutrient homeostasis, which likely contributes to overall pathogen fitness in host niches. Under oxidative stress, both transcription factors regulate a separate set of genes involved in detoxification of ROS and down-regulating ribosome biogenesis. ChIP-seq analysis, which reveals vastly different binding partners for each transcription factor (TF) before and after oxidative stress, further confirms these results. Furthermore, the absence of a dominant binding motif likely facilitates their mobility, and supports the notion that they represent a recent expansion of the ZCF family in the pathogenic Candida species. Our analyses provide a framework for understanding new aspects of the interface between C. albicans and host defense response, and extends our understanding of how complex cell behaviors are linked to the evolution of TFs.
“O mal de Alzheimer nacional”: (in)justiça, história e literatura
Authors: Da Cruz Lua Gill
Published: December 2016

Cinquenta anos depois do golpe militar brasileiro, as artes ainda procuram refletir e representar o período. Um dos grandes exemplos da literatura brasileira contemporânea, e sobre o qual este texto pretende versar, é o livro K. (2011), de Bernardo Kucinski. A trama centra-se na busca de um pai, K., por sua filha, A., desaparecida política no período do regime militar, e para a qual exige justiça, através da construção de uma narrativa. A leitura da obra proposta buscará contrastar diferentes áreas do conhecimento, como História, Psicanálise, Política e Direito, em especial com o texto de Shoshana Felman, O inconsciente jurídico (2002). A perspectiva levantada pela autora é a de que os julgamentos e a lei, de maneira geral, reproduzem e repetem os traumas sociais e políticos, a partir do seu inconsciente jurídico (dotada dos conceitos de trauma e de inconsciente de Freud). Os julgamentos históricos são marcados pela sua impossibilidade de escuta da voz do testemunho, enquanto a literatura seria o espaço no qual a hipocrisia da violência é colocada à prova, garantindo a escuta daqueles que não tem voz garantida no ambiente jurídico.
O caráter dialogal da língua por uma perspectiva instrucional da significação
Authors: Freitas Mara Rubia Rodrigues
Published: December 2016

Segundo Ducrot (1987), a significação da frase (na língua) permite construir instruções que o interlocutor deve seguir para atribuir sentido aos enunciados (no discurso). Considerando que o sentido é uma representação da enunciação, e que a encenação enunciativa prevê um eu que se dirige a um tu, é evidente o caráter dialogal do discurso. Embora a língua, na qualidade de sistema de formas abstratas, não seja generosa em evidenciar esse caráter, acreditamos que ela traga, inscrito no sistema, o substrato do diálogo, devido à natureza instrucional da significação. Nossa proposta é investigar como se configuram as instruções que permitem ao interlocutor recuperar sentidos construídos pelo locutor, tomando como marco a Teoria da Argumentação na Língua (ANL), abordagem que parte do discurso para explicar a língua. Nossa metodologia prevê a análise de uma peça publicitária à luz de conceitos da ANL, objetivando evidenciar a potencialidade dialogal da língua.
O jardim sem limites, de Lídia Jorge – ou, por outras palavras, a situação do Portugal pós-25 de abril
Authors: Minuzzi Luara Pinto
Published: December 2016

Este trabalho tem por objetivo pensar o livro O jardim sem limites, da escritora Lídia Jorge, como uma alegoria da situação de Portugal após a Revolução dos Cravos: o microcosmo Casa da Arara, onde os personagens do romance habitam, representaria o macrocosmo Portugal, assim como os habitantes do primeiro e do segundo andar e a tensão entre esses dois níveis, corresponderiam às diferentes gerações que compõem o povo português. Dessa forma, o cotidiano conflituoso em que convivem os moradores mais jovens do segundo piso e os mais velhos do primeiro seria a representação do distanciamento entre uma geração que viveu o salazarismo e que combateu o regime e outra que nasceu após o fim do totalitarismo e que não compreende os sacrifícios realizados pelos primeiros a fim de que todos pudessem usufruir da liberdade. Para tal análise, foram utilizados, como fundamentação teórica, estudos de filósofos que pensam a nação lusa, sua identidade e história, como Eduardo Lourenço, Boaventura de Sousa Santos e Jorge Babo.
A intolerância religiosa na literatura de Jorge Amado
Authors: Sperb Paula
Published: December 2016

A partir da proposta do eixo temático “Expressão de Conflitos”, do evento Duo VII – Dialogue Under Ocuupation, nos dispomos a fazer uma reflexão sobre a intolerância religiosa enquanto temática da literatura de Jorge Amado. A intolerância religiosa aparece especialmente na obra Tenda dos Milagres (1968), em cenas de perseguição aos pais-de-santo e terreiros de candomblé. Entendemos o fenômeno da intolerância racial como uma consequência das teorias raciais que vigoraram no Brasil como paradigma científico no final do século XIX e início do século XX. Essas teorias viam a raça como explicação para o primitivismo/atraso ou civilização/avanço. O candomblé, segundo essa perspectiva científica, por estar ligado à cultura africana (ou seja, negra), representava o suposto atraso do Brasil, que precisava ser combatido e solucionado. Quando foi deputado federal pelo partido comunista, Jorge Amado criou e aprovou a emenda que estabelecia a liberdade religiosa e de culto no Brasil, em 1946. Para realizar este trabalho utilizamos principalmente o suporte teórico de Leite (1976), Schwarcz (2001) e Skidmore (1989).
A leitura do hipertexto sob a perspectiva da Teoria da Enunciação
Authors: Rossa Juliana
Published: December 2016

Este artigo tem como objetivo realizar o cruzamento interdisciplinar das teorias da enunciação e do hipertexto. O estudo, de natureza teórica, caracteriza-se por ser uma análise que interliga as contribuições da teoria da enunciação de Émile Benveniste com teorias sobre hipertexto, pela ótica de autores como Lúcia Santaella, Pierre Lévy, Alex Primo e George Landow. Observamos que as categorias de pessoa, tempo e espaço – as quais Benveniste debita a subjetividade da linguagem – potencializam-se no hipertexto. Essa potencialização, que é uma das características do ciberespaço pela infinidade de elos multiconectados, induz a uma forma especial de leitura desses hipertextos. Dessa forma, propomos o termo hipersubjetividade da linguagem para tratar do discurso no ambiente virtual, o qual possui um leitor diferenciado e imersivo no complexo cenário do ambiente virtual.
Diálogos e(m) Sentidos
Authors: Barbosa Vanessa Fonseca , Di Fanti Maria da Glória Corrêa
Published: December 2016

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Uma entrevista com Yves Schwartz
Authors: Di Fanti Maria da Glória Corrêa , Barbosa Vanessa Fonseca
Published: December 2016

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Newly recorded and rare Desmidiales (Charophyta: Conjugatophyceae) from the Middle Urals, Russia
Authors: Shakhmatov Andrey S.
Published: December 2016

New disributional data on 14 previously unrecorded or rare species and varieties of algae belonging to Closteriaceae, Desmidiaceae, Gonatozygaceae and Peni­aceae (order Desmidiales) are presented for the Middle Urals. Closterium cornu Ehrenberg ex Ralfs, Closterium macilentum Brébisson, Closterium navicula (Brébisson) Lütkemüller, and Cosmarium crenulatum Nägeli are newly recorded to the Urals. A brief description, including measurements of cells as well as regional and global distribution, is given for each taxon.
Engineering the landscape – Capability Brown’s role
Authors: Clarke Barry Goldsmith , Barrett Benedict , Hudson Eleanor , Whibberley James
Published: December 2016

Celebrating the 300th anniversary of the birth of Capability Brown is an opportunity to recognise the significant contribution that the eighteenth-century landscape architect made to civil engineering, leaving a sustainable legacy. As a gardener, architect and engineer, he was responsible for over 250 gardens, transforming the landscape by extensive earthworks, drainage schemes, earth dams, roads and planting by using only the power of people and animals. Brown and his contemporaries such as Grundy Jr, Brindley, Ince and Smeaton were responsible for innovative engineering that survives today because of continuing investment and maintenance.
Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders
Authors: Michelfelder Stefan , Parsons Juliana , Bohlender Lennard L. , Hoernstein Sebastian N.W. , Niederkrüger Holger , Busch Andreas , Krieghoff Nicola , Koch Jonas , Fode Benjamin , Schaaf Andreas , Frischmuth Thomas , Pohl Martin , Zipfel Peter F. , Reski Ralf , Decker Eva L. , Häffner Karsten
Published: December 2016

Genetic defects in complement regulatory proteins can lead to severe renal diseases, including atypical hemolytic uremic syndrome and C3 glomerulopathies, and age-related macular degeneration. The majority of the mutations found in patients with these diseases affect the glycoprotein complement factor H, the main regulator of the alternative pathway of complement activation. Therapeutic options are limited, and novel treatments, specifically those targeting alternative pathway activation, are highly desirable. Substitution with biologically active factor H could potentially treat a variety of diseases that involve increased alternative pathway activation, but no therapeutic factor H is commercially available. We recently reported the expression of full-length recombinant factor H in moss (Physcomitrella patens). Here, we present the production of an improved moss-derived recombinant human factor H devoid of potentially immunogenic plant–specific sugar residues on proteinN-glycans, yielding approximately 1 mg purified moss–derived human factor H per liter of initialP. patensculture after a multistep purification process. This glycosylation-optimized factor H showed fullin vitrocomplement regulatory activity similar to that of plasma-derived factor H and efficiently blocked LPS-induced alternative pathway activation and hemolysis induced by sera from patients with atypical hemolytic uremic syndrome. Furthermore, injection of moss-derived factor H reduced C3 deposition and increased serum C3 levels in a murine model of C3 glomerulopathy. Thus, we consider moss-produced recombinant human factor H a promising pharmaceutical product for therapeutic intervention in patients suffering from complement dysregulation.
Most ApoL1 Is Secreted by the Liver
Authors: Shukha Khuloud , Mueller Jessica L. , Chung Raymond T. , Curry Michael P. , Friedman David J. , Pollak Martin R. , Berg Anders H.
Published: December 2016

Two coding sequence variants in the APOL1 gene (G1 and G2) explain much of the increased risk for FSGS, HIV-associated nephropathy, and hypertension-attributed ESRD among people of recent African ancestry. The ApoL1 protein is expressed in a wide variety of cell tissues. It has been assumed that the majority of circulating ApoL1 is produced by the liver, but this has not been shown. Using mass spectrometry, we genotyped and quantified the circulating ApoL1 in two liver transplant recipients whose native APOL1 genotype differed from the genotype of the deceased donors, allowing us to differentiate liver- from nonliver-produced ApoL1. Our findings confirm that the liver is indeed the main source of circulating ApoL1. However, the liver is not the sole source of circulating ApoL1, because we found that residual amounts of native ApoL1 continued to circulate in the blood, even after the liver transplant.
Progress in Understanding the Genetics of Calcium-Containing Nephrolithiasis
Authors: Sayer John A.
Published: December 2016

Renal stone disease is a frequent condition, causing a huge burden on health care systems globally. Calcium-based calculi account for around 75% of renal stone disease and the incidence of these calculi is increasing, suggesting environmental and dietary factors are acting upon a preexisting genetic background. The familial nature and significant heritability of stone disease is known, and recent genetic studies have successfully identified genes that may be involved in renal stone formation. The detection of monogenic causes of renal stone disease has been made more feasible by the use of high-throughput sequencing technologies and has also facilitated the discovery of novel monogenic causes of stone disease. However, the majority of calcium stone formers remain of undetermined genotype. Genome-wide association studies and candidate gene studies implicate a series of genes involved in renal tubular handling of lithogenic substrates, such as calcium, oxalate, and phosphate, and of inhibitors of crystallization, such as citrate and magnesium. Additionally, expression profiling of renal tissues from stone formers provides a novel way to explore disease pathways. New animal models to explore these recently-identified mechanisms and therapeutic interventions are being tested, which hopefully will provide translational insights to stop the growing incidence of nephrolithiasis.
Traducción al español de la escala de adicción a los alimentos de Yale (Yale Food Addiction Scale) y su evaluación en una muestra de población mexicana. Análisis factorial
Authors: Valdés-Moreno Mariana Isabel ,   Laboratorio de Neurofisiología Molecular, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz.,   Escuela de Dietética y Nutrición del ISSSTE., Rodríguez-Márquez María Cristina , Cervantes-Navarrete Juan José , Camarena Beatriz , de Gortari Patricia ,   Subdirección de Hospitalización, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz.,   Departamento de Farmacogenética, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz.
Published: December 2016

Resumen

Introducción. La obesidad es la acumulación excesiva de grasa corporal, lo que condiciona una alta comorbilidad. El consumo descontrolado de alimentos hipercalóricos es causa de su desarrollo; ésta es una conducta de características similares a la de pacientes con adicción a sustancias. La escala de adicción a los alimentos, YFAS (Yale Food Addiction Scale), permite identificar a sujetos con conducta adictiva a los alimentos.

Objetivo. Validar la escala YFAS en español en una muestra de población mexicana adulta.

Método. La muestra de participantes (160) respondió a la encuesta en dos ocasiones, con un período de tres semanas entre cada aplicación. La pertinencia de un modelo factorial se corroboró con las pruebas de esfericidad de Bartlett y la medición del parámetro de Kaiser-Meyer-Olkin.

Resultados. El α de Cronbach = 0.7963 corroboró la consistencia interna de la escala. Para la confiabilidad se obtuvo el coeficiente de Spearman por la metodología test-retest, de r = 0.565, n = 96. La validación por convergencia, correlacionando con la escala para trastorno por atracón (Binge Eating Scale, BES) (r = 0.5868 p ≤ 0.0001; n = 157). Las pruebas de Bartlett (χ2(300) = 1572.3, p < 0.05) y Kaiser-Meyer-Olkin (KMO = 0.825) mostraron pertinencia del modelo factorial. Además, se correlacionaron los resultados de la YFAS con el índice de masa corporal (IMC) (r = 0.2843 p ≤ 0.001; n = 151).

Discusión y conclusión. Esta versión de YFAS presentó propiedades psicométricas adecuadas y similares a las de la original y a otras de sus traducciones y adaptaciones. Se considera entonces con utilidad para la práctica asistencial y para estudios de investigación clínica en población mexicana.
Dyscalculia in children as a systemic problem of education
Authors: Ermolova Т.V. , Ponomareva V.V. , Florova N.B.
Published: December 2016

This article analyzes the researches by a number of national and foreign scholars on the issue of dyscalculia. The review of the results obtained allows tracking the changes in the concept of dyscalculia, its diagnostic criteria and strategies for targeted intervention designed for children of pre-school and primary school age. The analyzed studies basically refer to the modern understanding of the basic properties of dyscalculia - heterogeneity and the background of its formation, neuroanatomical prerequisites and the risks of inadequate interpretation of empirical data. They also define the primary and secondary dyscalculia and give an idea of the range of educational technologies. The article outlines the features of foreign and national approach to this issue. It appears that the priority of the problem of dyscalculia remains underestimated in comparison to dyslexia and other systemic psycho-pedagogical problems of childhood
Adaptation strategies of children with ADHD to the educational process
Authors: Adaskina A.A.
Published: December 2016

This article contains an overview of foreign works on adaptation of children with ADHD to school. The studies reviewed a number of topics that can be grouped as follows: part of them deals with the detailed study of social, pedagogical and psychological problems of children with ADHD; others, focused on medical aspects of ADHD like using psychostimulant, discusses the feasibility and effectiveness of such treatment and related risks. In this article we have focused on studies that have pronounced psycho-pedagogical aspect, i.e. the ones, examining the factors contributing to the success of the adaptation of children with ADHD to schooling and providing specific guidance on the various sides of the educational process (teaching children skills of self-organization, effective classroom environment, teaching compensating skills to children with ADHD, effective ways of presentation and testing of knowledge). The described strategy relied mainly on behavioral techniques that have proven to be quite effective in the process of correcting behavioral and educational problems of children with ADHD
Inside the Outside Series
Authors: Campbell Carol
Published: December 2016

This series explores the contrasts that exist between perception and reality.
If I Had a Hammer: Depictions of Inequality
Authors: Huynh Kim
Published: December 2016

2016 (work in progress)
If I Had a Hammer: File Cabinet
Authors: Huynh Kim
Published: December 2016

Canadian affairs file cabinet and cabinet’s shadow.
How Colonization Works
Authors: Wong Rita
Published: December 2016

Willful Ignorance and Officious Brutality, or How Colonization Works.
If I had a Hammer: Wall Mural (The Horse & Saddle)
Authors: Huynh Kim
Published: December 2016

2016 (work in progress)
If I Had a Hammer: Wall Mural (Installation View)
Authors: Huynh Kim
Published: December 2016

Embossed pages from perforating file cabinet are used to re-enact four significant Canadian stories: 1854, 1947, 1960, 2016.
Las competencias digitales en las grandes empresas del sector empresarial español. (Digital skills in big companies of the Spanish business sector)
Authors: Infante Moro Alfonso , Infante Moro Juan Carlos , Martínez López Francisco José , García Ordaz Mercedes
Published: December 2016

 Resumen

Este estudio surge a partir de otra investigación realizada sobre la evolución de las competencias digitales en el sector empresarial español, “Currícula en SI/TI en las empresas españolas: Estudio longitudinal (2001-2011)” (Infante, Infante, Martínez y García, 2015). Por tal motivo, se pretende situar la evolución de dichas competencias, habilidades digitales en las grandes empresas españolas, en un marco comparativo para cotejarlas con las del sector empresarial español en general, definiendo la importancia de estas habilidades y su evolución. Además, se busca encuadrarlas en el funcionamiento de estas empresas a través de las herramientas utilizadas y sus funciones dentro estas, con el fin de que los futuros trabajadores estén formados en las habilidades demandadas por dichas empresas. La investigación fue realizada a través de encuesta a 190 empresas, con una clara conclusión: el grado de conocimientos en competencias digitales es mayor para los futuros trabajadores de las grandes empresas que para los trabajadores de las empresas españolas en general.

 

Abstract

This study stems from another research about the evolution of digital skills in the Spanish business sector, “Curricula in IS/IT in Spanish companies: Longitudinal study (2001- 2011)” (Infante, Infante, Martínez y García, 2015). Therefore, it is intended to place the development of these abilities, digital skills in big Spanish companies, in a comparative frame to the Spanish business sector in general, defining the importance of them and their evolution. In addition, these skills were framed in the operation of these companies through the tools used and their functions within them, in order that future workers are trained in the skills demanded by these companies.

The research has been conducted through a survey to 190 companies, with a clear conclusion: the extent of the knowledge in digital skills more important for future workers in big companies that for workers in Spanish companies in general.
Las escuelas de pensamiento del emprendimiento social. Schools of Thought in Social Entrepreneurship
Authors: Bravo Monge Cris
Published: December 2016

Resumen

El emprendimiento social propone ser una promesa para el alivio de los problemas sociales del mundo. Al ser un concepto relativamente nuevo, la definición es sumamente amplia, lo cual resulta contraproducente para su construcción y diseminación. El propósito del estudio es identificar las diferentes propuestas de emprendimiento social llevadas a cabo por las cuatro principales organizaciones a nivel mundial que actualmente promueven el concepto de emprendimiento social: Fundación Ashoka, Fundación Skoll, Fundación Schwab y el Centro Yunus; así como de otras organizaciones practicantes y relacionadas con la enseñanza del concepto en educación superior. El estudio cualitativo utilizó el análisis de documentos de estas organizaciones, así como entrevistas a tres académicos expertos y practicantes del emprendimiento social. El estudio identificó tres escuelas de pensamiento claramente diferenciadas con base en su visión de cómo el ingreso, la escalabilidad y la replicabilidad de los proyectos afectan el emprendimiento social. El estudio provee evidencia de las diferencias importantes en la definición del concepto de emprendimiento social por parte de fundaciones más conocidas en el campo. La distinción de las escuelas de pensamiento es particularmente importante para la enseñanza y la definición de políticas públicas de emprendimiento social.

 

Abstract

Social Entrepreneurship is a new and exciting topic that holds a great promise in helping alleviate the social problems in the world. As a new subject, the meaning of the term is too broad which interferes with the construction and understanding of the concept. The purpose of this study is to identify the elements of the different proposals of what social entrepreneurship looks like, from the perspective of four organizations leading social entrepreneurship projects: Ashoka Foundation, Skoll Foundation, Schwab Foundation and Yunus Center; as well as from three other field and academic related institutions fostering and practicing social entrepreneurship. The study used document analysis from Skoll Foundation, Schwab Foundation, Yunus Center and Ashoka Foundation, and an open ended interview applied to experts from practitioner institutions. The study identified three clearly differentiated schools of thought, based on their views on revenue, scalability, replicability and geographic location. The definition of the different schools of thoughts is particularly important for the teaching of social entrepreneurship, and for the promotion of more adequate and accurate social policies to foster the development of social entrepreneurship.
Remuneración a la fuerza de ventas: variables que determinan su éxito o fracaso. Remuneration of sales force: Variables that determine your success or failure.
Authors: Torres Carballo Federico , Tiffer Sotomayor Haydeé , Sandoval Sánchez Yarima
Published: December 2016

Resumen

La remuneración a la fuerza de ventas es un tema fundamental en las organizaciones comerciales. ¿Qué tipo de incentivos incrementan el esfuerzo del vendedor para lograr las metas de la organización? ¿Si se combinan diferentes esquemas de incentivos se incrementa la dedicación del vendedor? Este es el primer estudio realizado en Costa Rica con técnicas experimentales para abordar tales cuestiones. Se realizan un conjunto de sesiones con más de doscientos estudiantes de carreras afines a la administración de negocios, a fin de estudiar, específicamente, los concursos de ventas cuyo esquema de remuneración consiste en un primer premio seguido de varios premios menores asignados según el logro de ventas por parte del vendedor. Se encontró que no siempre más es mejor y que algunas combinaciones en ambientes en los que los sujetos se comunican continuamente pueden hasta reducir el esfuerzo por lograr los objetivos organizacionales.

 

Abstract

The remuneration to the sales force is a major issue in commercial organizations. What kind of incentives increase the selling effort to achieve the goals of the organization? With the combination of different incentive schemes it is possible to increase seller’s dedication? This is the first study applied in Costa Rica, using experimental techniques to address such issues. A set of sessions are conducted with more than 200 students, from careers related to business administration, to study sales contests with a compensation scheme, in which there is a first prize followed by several smaller prizes assigned to the achieved sales made by the seller. It was found that it is possible to reduce the effort to achieve organizational objectives when the subjects can communicate constantly.
Regresión lineal simple y múltiple: aplicación en la predicción de variables naturales relacionadas con el crecimiento microalgal
Authors: Carrasquilla-Batista Arys , Chacón-Rodríguez Alfonso , Núñez-Montero Kattia , Gómez-Espinoza Olman , Valverde-Cerdas Johnny , Guerrero-Barrantes Maritza
Published: December 2016

En la actualidad, existe una creciente necesidad en diferentes campos de investigación y producción, y en la industria de la agricultura de precisión, de almacenar y procesar datos provenientes de múltiples sensores. Muchas veces estos dispositivos se encuentran ubicados en lugares remotos. El modo usual de recolección de datos implica el uso de un equipo para cada variable de interés, lo cual dificulta y encarece la integración y el procesamiento conjunto. Se considera entonces la posibilidad de incorporar la temática del Internet de las Cosas, con el fin de aprovechar las capacidades computacionales y de procesamiento en la nube para que los investigadores puedan disponer de la información que les permita tomar decisiones oportunas.

La presente investigación se centra en los modelos de regresión lineal, simple y múltiple, con el fin de establecer las bases para modelar la relación entre las variables de temperatura, luz, pH y oxígeno disuelto, y de esta manera poder conocer las factores que afectan l crecimiento del cultivo de microalgas en futuras investigaciones.
Medición automática del metano en biogás, por columnas de desplazamiento
Authors: Vaquerano-Pineda Nicolás , Salazar-Rojas Teresa , Porras-Acosta María
Published: December 2016

Aquí se describe un sistema automático implementado mediante el controlador LOGO de Siemens, para la medición de volumen, flujo y concentración de metano en biogás, producto de sustratos celulósicos. La determinación de la composición del biogás por cromatografía es un método que consume tiempo, recursos y detalla innecesariamente un amplio espectro de elementos. Debido al interés por el metano en biogás, se ha desarrollado una técnica por columnas de desplazamiento para la determinación de volumen y flujo de muy bajo caudal. Se implementa un procedimiento indirecto para estimar la presencia de metano en altas proporciones mediante sensores de bajo costo, ideados para concentraciones del 1% en volumen.
The Fusion of College English Flipping Class and Traditional Class--On the Degree of Class-Flipping
Authors: Zi Weili
Published: December 2016

Flipping Class emphasizes off-line learning with the problems resolved during class to fulfill the internalization. This could promote undergraduates’ innovative spirit and critical thinking. However, the essence in traditional teaching should not be ignored. This paper describes the experiment of fusion between traditional class and flipping class with the undergraduates of grade 2014 majoring in fashion and art from BIFT as the case. The action research conducted in this teaching experiment helps us find the great improvement of undergraduates involved in learning habit, learning attitude and English proficiency. Therefore, the author holds that quality teaching for the special learning subjects - undergraduates of fashion and art major could be achieved with the targeted fusion of traditional teaching and flipping teaching in the process of College English teaching. Meanwhile, when carrying out the flipping teaching mode, the characteristics of learning subjects and course taken are supposed to be considered with the moderate degree of flipping to maximize the effect of the new teaching mode.
Exact Solutions to (3+1) Conformable Time Fractional Jimbo-Miwa, Zakharov-Kuznetsov and Modified Zakharov-Kuznetsov Equations
Authors: Korkmaz Alper
Published: December 2016

Exact solutions to conformable time fractional (3+1)- dimensional equations are derived by using the modified form of the Kudryashov method. The compatible wave transformation reduces the equations to an ODE with integer orders. The predicted solution of the finite series of a rational exponential function is substituted into this ODE. The resultant polynomial equation is solved by using algebraic operations. The method works for the Jimbo-Miwa, the Zakharov-Kuznetsov and the modified Zakharov-Kuznetsov equations in conformable time fractional forms. All the solutions are expressed in explicit forms.
Enhancing Singapore’s Pension Scheme: A Blueprint for Further Flexibility
Authors: Kwong Koon-Shing , Tse Yiu-Kuen , Chan Wai-Sum
Published: December 2016

Building a social security system to ensure Singapore residents have peace of mind in funding for retirement has been at the top of Singapore Government’s policy agenda over the last decade. Implementation of the Lifelong Income For the Elderly (LIFE) scheme in 2009 clearly shows that the government spares no effort in improving its pension scheme to boost its residents’ income after retirement. Despite the recent modifications to the LIFE scheme, Singapore residents must still choose between two plans: the Standard and Basic plans. To enhance the flexibility of the LIFE scheme while maintaining its simplicity, we propose some plan modifications such that scheme members do not face a dichotomy of plan choices. Instead, they select two age parameters: the Payout Age and the Life-annuity Age. This paper provides an actuarial framework for determining members’ payouts and bequests based on the proposed age parameters. We analyze the net cash receipts and internal rate of return (IRR) for various plan-parameter configurations. This information helps members make their plan choices. To address cost-of-living increases we propose to extend the plan to accommodate an annual step-up of monthly payouts. By deferring the Payout Age from 65 to 68, members can enjoy an annual increase of about 2% of the payouts for the same first-year monthly benefits.
The Wear Resistance of Cryogenically Treated Diamond-Like Carbon Films
Authors: Han Lee-Long , Lin Chun-Ming , Shih Yih-Shiun
Published: December 2016

This study explored the effects of cryogenic treatment on the microstructure, hardness, and wear-resistance of diamond-like carbon (DLC) by cryogenically treating NAK 80 mold steel coated with DLC. Raman spectroscopy analyzed the structure of the DLC film. Nanoindenter analyzed the hardness and Young’s modulus of the film, and their relationship determined the wear resistance. Wear test assessed the wear rate and friction coefficient of the DLC film. The results showed that cryogenic treatment increased the rate of carbide precipitation and refined the grain structure. Raman spectroscopy indicated that the Raman intensity rate (ID/IG) of treated DLC films was smaller than those without cryogenic treatment. When the sp3 bond increased, the hardness and wear-resistance of the DLC film also increased.
Design of Octagonal Fractal Array Antenna for Side Lobe Reduction with Morse-Thue Fractal Density Tapering Technique
Authors: Ponnapalli V. A. Sankar , Pappu V. Y. Jayasree
Published: December 2016

Fractal array antennas are multiband arrays having ultra wide band and space filling facility. But Side lobe levels and large number of antenna elements are the major designing challenges of these arrays. In this paper, design and analysis of octagonal fractal array antenna is investigated with Morse-Thue fractal density tapering technique (MTFDT). Due to the proposed technique, a remarkable improvement has observed in Side lobe levels and thinning of the elements can also be attained at the various iterations of octagonal fractal array antenna. These arrays are analyzed and simulated by MATLAB-15 programming.
Potential Enhanced Survivorship of Crown of Thorns Starfish Larvae due to Near-Annual Nutrient Enrichment during Secondary Outbreaks on the Central Mid-Shelf of the Great Barrier Reef, Australia
Authors: Brodie Jon , Devlin Michelle , Lewis Stephen
Published: December 2016

The Great Barrier Reef (GBR) is currently experiencing widespread crown of thorns starfish (CoTS) outbreaks as part of the fourth wave of outbreaks since 1962. It is believed that outbreaks have become more frequent on the GBR and elsewhere in the Indo-Pacific associated with anthropogenic causes. The two widely accepted potential causes are (1) anthropogenic nutrient enrichment leading to increased biomass of phytoplankton, the food of the planktonic stage of larval CoTS; and (2) overfishing of predators on the juvenile to adult stages of CoTS, for example, commercial fished species such as coral trout. In this study, we show the evidence for the nutrient enrichment causation hypothesis is strong based on a large number of recent studies in the GBR. We also hypothesise that secondary outbreaks in the region between Cairns and Townsville can also be enhanced by nutrient enriched conditions associated with the annual nutrient discharge from Wet Tropics rivers.