bluuebunny/crossref_metadata_2025 huggingface dataset:
La guerra anglo-argentina de 1982. Los incómodos límites auto-impuestos por una antropología conformista
Authors: Guber Rosana
Published: January 2025

Resumen Este artículo analiza cómo las reflexividades generadas en las investigaciones antropológicas están modeladas por los valores de cada época histórica. Ese análisis puede enseñarnos a los investigadores sociales a comprender los modos en que el trabajo analítico académico suele exotizar las alteridades que deseamos conocer, aunque esas exotizaciones se sostengan en razones de afinidad política y/o conciencia humanitaria. La autora analiza aquí su propia trayectoria entre 1989 y 2022 como investigadora del conflicto armado de 1982 entre la República Argentina y el Reino Unido, conocido como la guerra de Malvinas (eng. Falklands), un hecho bélico protagonizado, del lado argentino, por militares profesionales y soldados conscriptos. A través de una caracterización dinámica de su propia trayectoria, ella nos muestra cómo los sucesivos climas político-morales de la posguerra fueron autorizando formas de conocimiento académico, fundadas en moralidades supuestamente ahistóricas que restan historicidad a las experiencias de los combatientes argentinos. Para restituirles a esos climas su dinámica histórica, la autora analiza las reflexividades puestas en juego entre académicos y militares argentinos, a lo largo de tres décadas de investigación antropológica, atravesadas por procesos globales, nacionales y personales que obligaron a sucesivas reelaboraciones de un hecho social único en todo el siglo XX para la República Argentina: el involucramiento estatal-nacional como principal contendiente en un campo de batalla internacional.
Incomodidades e intervenciones antropológicas en escenarios de reformas democratizadoras de Fuerzas de Seguridad y Armadas, en Argentina.
Authors: Frederic Sabina A.
Published: January 2025

Resumen Este artículo da cuenta de cómo la investigación de objetos socio históricamente incómodos, como en Argentina aquellas que atendieran al punto de vista de policías, gendarmes y militares, se tornó un modo de intervención antropológica en procesos políticos específicos. Para ello, destaca los hitos que convirtieron el escenario de nuestra investigación en uno marcado por sucesivas e intermitentes reformas democratizadoras con el objeto de subordinar al poder político a militares y policías. Asimismo, analiza nuestra inserción en ese terreno, donde se sucedieron y solaparon, la investigación y el ejercicio de la función pública, para poner de relieve las condiciones de producción, las estrategias de publicidad y confidencialidad, la rendición de cuentas sobre nuestros resultados y fundamentalmente los escenarios producidos junto a militares, gendarmes y policías, para construir con ellos políticas sustentables en educación y bienestar.
Filming Up: Brazilian Elites Through an Ethnographic Lens
Authors: Vailati Alex , Andrade Walter
Published: January 2025

Abstract This article is based on the idea of filming up, contextualizing it in both visual anthropology and documentary history. We will first offer a brief analysis of audiovisual production concerning elites to reflect on how they are pictured and how this is of interest to anthropological studies. Considering the category of production infrastructure, we will then focus on the cinema scene in the city of Recife (Brazil), underlining how it enables the production of documentaries that focus on elites. Social inequalities within and outside cinema production infrastructure allow the affirmation of several directors, who implicitly contest this postcolonial order through their production focused on empowered groups. The analysis will show that movies are potential tools for creating ephemeral communities, enabling critical confrontation between separated social groups. Moreover, we will underline how these production practices potentially stress visual anthropological theory, forcing us to reconsider both the practices of visual fieldwork and the mainstream linguistic form that circulates within festivals and teaching institutions.
Más allá del trabajo técnico: Conflictos, derecho y política entre los Tupiniquim y Guarani-Mbyá en Espirito Santo (Brasil)
Authors: Veiga Felipe Berocan
Published: January 2025

Resumen Este artículo busca reflexionar, retrospectivamente, sobre experiencias de consultoría ambiental para la producción de trabajos técnicos, informes y relatos antropológicos sobre tierras y poblaciones indígenas (Tupiniquim y Guarani-Mbyá) en el municipio de Aracruz, en Espírito Santo (Brasil), en un contexto de proximidad y conflictos territoriales con grandes proyectos de desarrollo. La ocasión oportuna de celebración de la “fiesta de la victoria” en 2007 permite al antropólogo regresar al campo un año después de la aprobación y publicación en audiencias públicas de estos documentos en un proceso de licenciamiento ambiental - esta vez, sin embargo, liberado de su cargo de consultor contratado. Observar los cuadros de la acción política en situación permite comprender los resultados de las luchas indígenas en las arenas públicas y, al mismo tiempo, atribuir nuevos significados al trabajo técnico desarrollado, reflexionando sobre sus posibles aportes a la ampliación de las tierras indígenas demarcadas en la región.
Ear acupuncture with laser and needles in the treatment of anxiety in university students: a randomized clinical trial
Authors: Lemos Ana Paula da Silva , Lourenço Bárbara Guimarães , Chaves Érika de Cássia Lopes , Toledo Luana Vieira , Chianca Tânia Couto Machado , Moura Caroline de Castro
Published: January 2025

ABSTRACT Objective: To compare the effectiveness of ear acupuncture with laser and needles in the treatment of anxiety in university students in the post-pandemic context of Covid-19, as well as to evaluate the possible symptoms or adverse reactions triggered by the interventions. Method: Randomized clinical trial carried out with 126 university students, allocated to the “Needle” (control) and “Laser” (experimental) groups. Five ear acupuncture sessions were performed. Assessments were performed before, after the end of treatment and seven days later (follow up), through the State Anxiety Inventory and the measurement of heart and respiratory rates. The Generalized Estimating Equations were used. Results: There was a reduction in anxiety levels in both groups, between the initial and final assessments, and initial and follow up. There was no difference between the groups in the final and follow up. Heart rate decreased in the Needle group between the final and follow up, and initial and follow up assessments; the Laser group remained constant over time and the groups did not differ from each other between the end and follow up. There was no change over time in respiratory rate in either group and they did not differ from each other in the final and follow up assessments. There was a higher occurrence of adverse reactions in the group that received the intervention with needles, despite the mild intensity. Conclusion: Both interventions were effective in reducing anxiety levels in university students. Brazilian Clinical Trials Registry RBR-8cxnvr2.
Entrepreneurial Education for Amazon’s Sustainable Development: An Evaluation of the Genesis Program
Authors: Carneiro Lucas Carregari da Rosa , Almada Hellen Kezia Silva , Cavalcante Rosane Barbosa Lopes
Published: January 2025

ABSTRACT Objective: this article evaluates the Genesis Program, part of the Amazon Journey, created to awaken local entrepreneurial talents and strengthen the business ecosystem based on the forest’s biodiversity. Theoretical approach: it argues that developing behavioral skills and fostering an active learning community are essential for this goal. Methods: the theoretical analysis is grounded in experiential learning, emphasizing the dimensions of action and reflection, experience and abstraction, and the principles of engagement in discovery activities, courage cultivation, associative thinking, and diversity, which are essential for innovation. The research uses questionnaires (n = 147) and interviews (n = 26) to collect participants’ perceptions and analyze the program’s evolution over time. Results: as a result, the Genesis Program recorded 7,177 enrollments across the nine states of the Legal Amazon, involving more than 160 municipalities and generating 585 new entrepreneurial solution ideas. Conclusion: it was found that there was a need to improve the engagement method, leading to the development and application of new training formats. The 37 local ambassadors were identified as essential for the program’s reach and achieving objectives. The article shares lessons learned and seeks to inspire new research and initiatives for developing talents in entrepreneurship, innovation, and bioeconomy fields.
Educação Empreendedora para o Desenvolvimento Sustentável na Amazônia: Uma Avaliação do Programa Gênese
Authors: Carneiro Lucas Carregari da Rosa , Almada Hellen Kezia Silva , Cavalcante Rosane Barbosa Lopes
Published: January 2025

RESUMO Objetivo: Este artigo avalia o Programa Gênese, parte da Jornada Amazônia, criado para despertar talentos empreendedores locais e fortalecer o ecossistema de negócios baseado na biodiversidade da floresta. Marco teórico: Defende-se que o desenvolvimento de competências comportamentais e uma comunidade ativa de aprendizado são essenciais para esse objetivo. Metodologia: A análise teórica é fundamentada na aprendizagem experiencial, com ênfase nas dimensões de ação e reflexão, experiência e abstração, além das premissas de engajamento em atividades de descoberta, cultivo da coragem, pensamento associativo e diversidade, essenciais para a inovação. A pesquisa utiliza questionários (n=147) e entrevistas (n=26) para coletar a percepção dos participantes e analisar a evolução do programa ao longo do tempo. Resultados: Como resultado temos que o Programa Gênese registrou 7.177 inscrições nos 9 estados da Amazônia Legal, envolvendo mais de 160 municípios e gerando 585 novas ideias de soluções empreendedoras. Conclusão: Contudo, constatou-se a necessidade de aprimorar o método de engajamento, resultando em novos formatos de capacitação desenvolvidos e aplicados. Destaca-se também que seus 37 embaixadores locais foram identificados como essenciais para a capilaridade e alcance dos objetivos do programa. O artigo compartilha aprendizados e busca inspirar novas pesquisas e iniciativas para o desenvolvimento de talentos nos temas de empreendedorismo, inovação e bioeconomia.
Sociobioeconomy and Social Technology in the Amazon Region: An Integrated Framework Proposition
Authors: Rodrigues Diana Cruz , Ribeiro Artur da Silva , Silva João Paulo dos Santos da , Passador Cláudia Souza
Published: January 2025

ABSTRACT Objective: To propose an analytical framework that integrates the social technology approach into the concept of socio-bioeconomy, as its compatible technological strand, based on the concept of a social technological system. Theoretical framework: The concept of socio-bioeconomy is discussed in light of the three predominant visions of bioeconomy (biotechnological, bioresources, and bioecological), proposing a conceptual-analytical framework. The social technological system concept is revised to integrate it, in a cross-cutting way, with the socio-bioeconomy. The framework integrates the dimensions of the social technological system with the dimensions of the socio-bioeconomy. Methods: The proposed framework was applied in a case study of a potential social technological system in socio-bioeconomic activities in the rubber production chain in the Amazon. Data collection included documentary research, interviews, and a technical visit. Results: the case study presented the integration of three solutions based on social technology, constituting various properties of a social technological system. The social technology system shown was compatible with the dimensions of socio-bioeconomy. Several properties of the framework were evidenced, allowing its initial analytical viability to be considered. Conclusions: The framework has advanced in the analytical detailing of socio-bioeconomy, including its technological aspect, by bringing it closer to social technology. The framework can also help with technological development in socio-bioeconomy initiatives.
Sociobioeconomia e Tecnologia Social na Amazônia: Uma Proposta de Framework Integrado
Authors: Rodrigues Diana Cruz , Ribeiro Artur da Silva , Silva João Paulo dos Santos da , Passador Cláudia Souza
Published: January 2025

RESUMO Objetivo: propor um framework analítico que integre na concepção de sociobioeconomia a abordagem de tecnologia social, enquanto sua vertente tecnológica compatível, baseada no conceito de sistema tecnológico social. Marco teórico: A concepção de sociobioeconomia é discutida frente as três visões predominantes de bioeconomia (biotecnológica, biorrecursos e bioecológica), com a proposição de um quadro conceitual-analítico. A concepção de sistema tecnológico social é revisada para se integrar, de forma transversal, à sociobioeconomia. O framework integra dimensões do sistema tecnológico social às dimensões equivalentes da sociobioeconomia. Métodos: o framework proposto foi aplicado em um estudo de caso de potencial sistema tecnológico social na cadeia produtiva da borracha na Amazônia, atividade da sociobioeconomia. A coleta de dados contemplou pesquisa documental, entrevistas e visita técnica. Resultados: o caso em estudo apresentou a integração de três soluções baseadas em tecnologia social, constituindo diversas propriedades de um sistema tecnológico social. O sistema tecnológico social evidenciado mostrou-se compatível com as dimensões de sociobioeconomia. Diversas propriedades do framework foram evidenciadas, permitindo considerar a sua viabilidade analítica inicial. Conclusões: O framework avançou no detalhamento analítico-conceitual da sociobioeconomia, incluindo sua vertente tecnológica, pela aproximação com a tecnologia social. O framework também pode auxiliar no desenvolvimento tecnológico em iniciativas da sociobioeconomia.
Effect of application of the thoracoabdominal rebalancing (TAR) method in moderate premature children: randomized and controlled clinical trial
Authors: Lemos Jaqueline Lomônaco , Iunes Denise , Danaga Aline Roberta , Rocha Carmélia , Borges Juliana Bassalobre Carvalho
Published: January 2025

ABSTRACT Objective: To analyze the effect of the thoracoabdominal rebalancing (TAR) method on respiratory biomechanics, respiratory discomfort, pain sensation, and physiological parameters in moderate preterm newborns, compared to a control group. Methods: This randomized clinical trial was conducted in a neonatal intensive care unit. The evaluation included: Neonatal Infant Pain Scale, physiological parameters, Silverman-Andersen score, and biomechanics (thoracic cirtometry and Charpy angle). The newborns were randomized into the TAR group (n=17) or control group (n=13) and subjected to the slow expiratory flow acceleration technique (SEFA). The evaluation of a single session was performed three times: before, after, and 30 minutes after the intervention. Results: In the intergroup comparison, there was a significant difference in respiratory rate 30 minutes after the intervention. There was no significant difference in intra- and intergroup comparisons for pain and respiratory discomfort. Regarding biomechanics, there was a significant difference in the TAR group in the Charpy angle (between assessments 1 and 2), in the axillary cirtometry (between assessments 1 and 3), and in the xiphoid process (between assessments 2 and 3). In the control group, a significant difference was observed in the axillary line (between assessments 1 and 2; 2 and 3). Conclusions: The TAR method showed a positive effect on respiratory rate and respiratory biomechanics when compared to the control group. In both groups, the techniques did not promote respiratory discomfort or pain sensation, making them safe techniques for this population.
Swine clones: potential application for animal production and animal models
Authors: Nesiyama Thaís Naomi Gonçalves , Sangalli Juliano Rodrigues , De Bem Tiago Henrique Camara , Recchia Kaiana , Martins Simone Maria Massami Kitamura , Andrade André Furugen Cesar de , Ferst Juliana Germano , Almeida Gustavo Henrique Doná Rodrigues , Marques Mariana Groke , Dória Renata Gebara Sampaio , Carregaro Adriano Bonfim , Feliciano Marcus Antônio Rossi , Miglino Maria Angélica , Bressan Fabiana Fernandes , Perecin Felipe , Silveira Juliano Coelho da , Smith Lawrence Charles , Bordignon Vilceu , Meirelles Flávio Vieira
Published: January 2025

Abstract Somatic cell nuclear transfer (SCNT), or cloning, is used to reprogram cells and generate genetically identical embryos and animals. However, the cloning process is inefficient, limiting its application to producing valuable animals. In swine, cloning is mainly utilized to produce genetically modified animals. Indeed, recombinant DNA technologies have evolved considerably in recent years, with homologous recombination and gene editing technologies becoming more efficient and capable of recombining both alleles in a single cell. The selection of appropriate cells and their use as nuclear donors for SCNT is the most common method for generating edited and genetically modified animals for commercial and research purposes. This article reviews current applications of swine cloning and shares our personal experiences with the procedure in this species.
Taxonomic study of Oxalis section Thamnoxys (Oxalidaceae) in Brazil
Authors: Abreu Maria Carolina de , Oliveira Ykaro Richard , Santos Juliana Silva dos , Carvalho Reginaldo , Silva Marcos José da , Sales Margareth Ferreira de
Published: January 2025

Abstract Oxalis comprises ca. 500 species and has a tropical and subtropical distribution. This genus contains four subgenera and Oxalis subg. Thamnoxys is the most diverse in Brazil. This subgenus has 9 sections, of which section Thamnoxys is the most diverse with 28 species. This work is based on a taxonomic study of Oxalis section Thamnoxys in Brazil and includes descriptions, illustrations, and notes for the recorded species. The following species were recorded: Oxalis barrelieri, O. cerradoana, O. clausenii, O. cratensis, O. cytisoides, O. diamantinae, O. divaricata, O. frutescens, O. hedysarifolia, O. hyalotricha, O. jacobinensis, O. mucronulata, O. nigrescens, O. pilulifera, O. pyrenea, O. renifolia, O. sellowii, O. sepium, and O. suborbiculata. These species are mostly distributed in rainforest and seasonal semi-deciduous forest.
Therapeutic strategies for tongue musculature: a systematic literature review
Authors: Otavio Andressa Colares da Costa , Fernandes Arthur Cherem Netto , Andrade Maria Eduarda Pollachinni , Dias Brenda Barros , Gomes Erissandra , Vaz Marco Aurélio
Published: January 2025

ABSTRACT Purpose To analyze the different therapeutic strategies prescribed in orofunctional rehabilitation of the tongue musculature. Research strategies Regional Portal of the Virtual Health Library for Latin America and the Caribbean, Embase, PubMed/MEDLINE, Scientific Electronic Library Online, SciVerse Scopus and Cochrane databases were consulted, with the descriptors "exercise therapy” OR “physiology” OR “musculoskeletal physiological phenomena” OR “digestive system and oral physiological phenomena” AND “speech therapy” OR “myofunctional therapy” OR “speech language pathology” AND “tongue”. Studies indexed until October 5, 2023, were included. Selection criteria Studies with an interventionist design with exercises for tongue musculature were included. Data analysis Three reviewers selected, extracted and tabulated the information from the studies. The PEDro scale was used to measure the studies’ methodological quality. Results 1.036 studies were found, and 18 were included in this review. The samples varied between 16 and 148 subjects, aged between 4 and 95 years. Only seven studies clearly described the exercises execution, and the number of sets, repetitions, and contraction duration. Fourteen studies clearly defined the exercises’ objectives. The average score of the PEDro Scale analysis was 6.9, and 56.25% of the studies scored ≥7. Conclusion There is a lack of a clear description of the exercises’ goals and their clinical indications, which can lead to confusion and inadequate prescription. Future studies will need to provide a clear description of the outcomes, in order that we can define, according to the exercises and training program specificity, what the effects of different training methodological parameters in this musculature are.
Self-perception of stuttering: association with self-perception of hearing, fluency profile, and contextual aspects
Authors: Silva Camila Eduarda Elias , Britto Denise Brandão de Oliveira , Lemos Stela Maris Aguiar
Published: January 2025

ABSTRACT Purpose This study investigated the association between self-perception of stuttering and self-perception of hearing, speech fluency profile, and contextual aspects in Brazilian adults who stutter. Methods Fifty-five adults who stutter (ages 18 to 58 years), speakers of Brazilian Portuguese speakers, participated in an observational study that included: (a) a clinical history survey to collect identification, sociodemographic, clinical, and assistance data; (b) the Brazil Economic Classification Criteria (CCEB); (c) a hearing self-perception questionnaire (Speech, Spatial and Qualities of Hearing Scale – SSQ, version 5.6); (d) self-perception of the impact of stuttering (Brazilian Portuguese version of the Overall Assessment of the Speaker's Experience of Stuttering – Adults – OASES-A); and (e) an assessment of speech fluency (Fluency Profile Assessment Protocol -- PAPF). Data analysis consisted of descriptive and bivariate analysis using Pearson’s chi-square, Mann-Whitney, Kruskal-Wallis, and Spearman correlation coefficient. Results Most participants were classified as moderate to severe in the total classification of the impact of stuttering. There were moderate and weak negative correlations between the participants' self-perception of stuttering and self-perception of hearing. Conclusion Self-perception of auditory abilities was greater to the extent that self-perception of the impacts of stuttering on quality of life was lower.
DIFFERENT SALES MODELS, FUNCTIONAL AND RELATIONAL CUSTOMER ORIENTATION, AND RETAIL SALESPERSON PERFORMANCE
Authors: Adão Alyson Luis , Kato Heitor Takashi , Briggs Elten , Deretti Sandro
Published: January 2025

ABSTRACT This study tests the effect of different sales models on a conceptual model based on creativity theory, linking retail salespersons’ functional and relational customer orientation to their performance. Salespersons’ creativity and retailers’ different sales models are considered to be mediating and moderating variables. We collected dyadic data from retail managers and salespeople across 177 retail companies in Brazil and used PLS-SEM to test the study’s hypotheses. The results show that the moderation exerted by distinct sales models offered by a company contributes to the heightened prominence of creative salespersons operating in the retail sector, as they can adapt their sales strategies effectively. Furthermore, the results indicate that functional customer orientation negatively moderates the effect of relational customer orientation on creativity, which suggests that attempting to simultaneously implement both customer orientations is suboptimal in retail selling contexts.
Simultaneous gains for negatively correlated traits of interest in plantain
Authors: Santos Geferson Rocha , Santos Letícia Casseano de Souza , Almeida Rafael Nunes de , Pereira Hércules dos Santos , Trindade Inês de Moura , Pretti Irany Rodrigues , Barbosa Dimmy Herllen Silveira Gomes , Amorim Edson Perito , Berilli Sávio da Silva , Berilli Ana Paula Candido Gabriel
Published: January 2025

Abstract The objective of this work was to identify negative correlations between phenotypic characteristics (agronomic and physicochemical) in plantain (Musa paradisiaca), and to evaluate selection indices to obtain simultaneous gains for agronomically relevant characteristics. Thirteen plantain genotypes were evaluated in a randomized complete block design with four replicates. Data on 16 agronomic and physicochemical traits were collected. Genotype dispersion regarding the set of traits was evaluated using the principal component analysis and the separation of dissimilarity groups via clustering (Mahalanobis distance). The genotypes were divided into four groups, in which genotypes 13 (commercial) and 9 (wild) formed isolated groups. Positive correlations between yield and plant height, in addition to negative correlations between these two and the content of soluble solids (SS) were identified. Taller plantain plants had the tendency to produce more, but with late fruit, which were more acid and had a lower SS content. Therefore, correlations between yield, plant height, and SS posed a challenge for the development of plantain cultivars. The index of Mulamba & Mock was applied, which allowed of obtaining simultaneous gains in the target traits. The multitrait selection indices are appropriate to identify plants that are shorter, more productive, and that have fruit with a higher SS contents.
Impact of carbonation on reinforced concrete structures, considering the increase of CO2 due to climate change in Brazil
Authors: Teodoro Chiara Pinheiro , Carrazedo Rogério
Published: January 2025

Abstract Corrosion in reinforced concrete structures has become a growing concern, primarily due to climate change-related factors such as the rise of carbon dioxide levels, temperature fluctuations, and altered precipitation patterns. To address this, regional assessments are vital due to varying environmental impacts. This study examines corrosion in Brazil, focusing on urban CO2 levels, employing NBR 6118 (2023) to predict depassivation, initial cracks, and failure due to excessive displacement (Serviceability Limit State). Results indicate a 50% depassivation probability within 13 years for a 2.5 cm concrete cover in the worst-case scenario. Additionally, the diameter of reinforcements greatly influences failure probability for excessive displacement, with a 311% increase over 45 years using a 5 mm diameter instead of 10 mm. These findings underscore the urgency of adapting construction practices to consider accelerated carbonation rates in urban environments and the need for ongoing research to refine predictive models and update construction standards accordingly.
A hydrogel based herbal nanoformulation for enhanced wound healing
Authors: Sultana Shaheen , Alzahrani Nada , Alzahrani Reem , Alshamrani Wejdan , Aloufi Waad , Khan Maria , Yusuf Mohammad
Published: January 2025

Abstract The aim of the present study is to develop a chitosan based herbal formulation using rhubarb for wound healing. Wound healing is a dynamic process facilitating the regeneration or repair of broken tissue. Rhubarb is commonly used worldwide for their effective antiseptic, antifungal and antiviral properties. Rhubarb loaded chitosan nanoparticles were prepared by ionic cross-linking process with sodium lauryl sulphate. The optimized formulation was examined for antibacterial activity against S. aureus and P. aeruginosa. Wound healing effects of the developed formulation was studied on excision wound model in Wistar albino rats. Average particle size and zeta potential of chitosan nanoparticles varied from 93 to 2,225 nm and from+30.82 to -16.08 mV, respectively. On the basis of particle size, zeta potential, and % entrapment, Formulation C 4 (0.0595% chitosan, 0.535% cross-linker, and 1% drug) was selected among different checkpoint formulation and further studies were performed. Hydrogel was developed using a combination of polyvinylpyrrolidone and carboxymethyl cellulose. Nanoformulation based hydrogel showed significantly enhanced antimicrobial activity against tested pathogenic microbial strains in comparison to drug solution, as well as marketed formulations.
Monte Carlo simulation methods-based models for analyzing the kinetics of drug delivery from controlled release systems
Authors: Jiménez-Jiménez Saúl , Cordero-Sánchez Salomón , Mejía-Hernández José-Gerardo , Quintanar-Guerrero David , Melgoza-Contreras Luz-María , Villalobos-García Rafael
Published: January 2025

Abstract Pharmaceutical controlled-release formulations are systems developed by a set of unit operations to achieve a satisfactory combination between a drug and excipients to allow its gradual release. These devices must simultaneously meet criteria for stability, biocompatibility, safety, efficacy, scalability at industrial volumes, and technological efficiency for drug release. Controlled-release systems (CRSs) must release drugs in a way that maintains an adequate concentration in the organism, a requirement that is challenging to meet in practice. Even though novel CRSs may be designed with new materials as excipients, new drugs, or emerging manufacturing technologies, the mechanisms for drug release continue to be governed by a set of similar physicochemical phenomena such as diffusion, swelling, or erosion. These phenomena are too complex to be analyzed by numerical methods; however, they are relatively accessible by probabilistic models especially the Monte Carlo simulation. In this review, we discuss key findings related to the use of this probabilistic method for analyzing the drug-controlled release process in different pharmaceutical devices. Based on this evidence, we propose their potential application in the characterization of new drug-controlled release systems, synergy with other computational methods, and their capability to be adapted for in vivo or in vitro kinetic analysis.
New discoveries of the action of L-ascorbic acid (vitamin C) - Enhanced efficacy in formulations
Authors: Oliveira Andressa Costa de , Morocho-Jacome Ana Lucia , Martins Tércio Elyan Azevedo , Pinto Claudinéia Aparecida Sales de Oliveira , Baby André Rolim , Velasco Maria Valéria Robles
Published: January 2025

Abstract Skin oxidation can impair physiological functions and induce skin diseases, such as photoaging and cancer. L-ascorbic acid (L-AA), or vitamin C, is commonly used in cosmetics because it is a potent antioxidant, inhibits melanogenesis, and promotes collagen and elastin synthesis in the skin. This study developed strategies to improve the stability of L-AA in its pure form with or without caffeic acid (CA) and evaluated its clinical efficacy using an ex vivo method. Oil/water emulsions were prepared with antioxidants and normal stability tests were conducted (various temperatures for 360 days). Antioxidant activity was assessed using a DPPH assay, and L-AA content was quantified by high-performance liquid chromatography. The thiobarbituric acid reactive substances method characterized the inhibition of lipid peroxides in the stratum corneum ex vivo. The formulation F1 (base + 10.0% L-AA) exhibited better L-AA stability over 360 days. The formulations F1 and F2 (base + 10.0% L-AA + 0.2% CA) increased the production of lipid peroxides when applied to the stratum corneum ex vivo and irradiated; however, when not irradiated, they inhibited the production of reactive oxygen species. For greater clinical efficacy of vitamin C on the skin, nighttime use is suggested as well as storage at low temperatures.
Personalized solutions for ENT implants: The role of 3D/4D printing
Authors: Vyas Jigar , Raytthatha Nensi , Vyas Puja , Patel Jitendra
Published: January 2025

Abstract 3D printing, a newer manufacturing technology, is gaining prominence in the pharmaceutical and healthcare sectors, particularly ENT implants. It enables the production of customized biological tissue scaffolds, portable models, and surgical training aids. The emergence of 4D printing offers the potential for enhancing ENT therapy safety and efficacy. The manuscript explores the potential of 3D printing to revolutionize pharmaceutical and clinical practice, enabling the development of personalized drug formulations, patient-centric implants, and anatomical models. This review delves into the emerging concept of “smart” biomaterials used in 4D printing, which are capable of mimicking natural tissues and responding to external stimuli. This paves the way for significant advancements in ENT tissue engineering with the potential to increase treatment safety and efficacy. This highlights the importance of healthcare staff in translating 3D printing innovations into clinical practice for successful adoption. The manuscript highlights the transformative impact of 3D printing in the pharmaceutical and healthcare industries. 3D printing and bioprinting technologies are revolutionizing ENT therapy, offering novel avenues for improved patient care and fostering advancements in the healthcare field.
Physiologically Based Pharmacokinetic and Physiologically Based Biopharmaceutic models research in Latin America: A regional level bibliometric analysis, 2011-2023
Authors: Ribeiro Marx , Cardoso Juliana Cordeiro , Martins José Eduardo Severino , Pinto Aline Ferreira , Souto Eliana Maria Barbosa , Severino Patricia
Published: January 2025

Abstract The landscape of scientific research in Latin America (LA), particularly in the realms of the Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutic models (PBPM), is a mosaic of varied contributions, collaborations, and specializations. This study examines research production in the region using data from the Scopus and PubMed databases collected between 2011 and 2023. Brazil stands out as a prominent country in terms of the quantity of publications. When considering thematic specialization, Colombia cones first as the country with the greatest Relative Specialization Index (RSI), followed by Brazil, Cuba, Uruguay, Mexico, and Argentina. Regarding internationalization, Brazil and Mexico are currently exerting significant influence, particularly through their increasing cooperation with the United States and Europe. Interestingly, there is a lack of cooperation inside Latin America at the regional level. Regarding the contribution of Latin-American institutions, the State University of Maringá leads in number of publications, followed by the University of São Paulo and the Federal University of São Paulo. In this work, we analyzed the strengths and weaknesses of LA’s scientific contributions, offering a roadmap for future collaborative and specialized efforts in the field of PBPK and PBBM.
Machine learning based QSAR and Molecular Dynamics simulations in the structural design and mechanism of action of imidazole derivatives with anti-melanoma activity
Authors: Oliveira Neto Rosalvo Ferreira de , Silva Sérgio Ruschi Bergamachi , Leal Cintia Emi Yanaguibashi , Alencar Filho Edilson Beserra de
Published: January 2025

Abstract Cancer is defined as a group of diseases in which abnormal cells multiply and can invade other organs, requiring continuous studies for new drugs. A series of 177 imidazo[1,2-a]pyridine and imidazo[1,2-a] pyrazine synthetic derivatives were previously obtained, and their anti-melanoma IC50 values have been determined. Here, Artificial Intelligence algorithms were used to select molecular descriptors and build a QSAR model, highlighting structural characteristics related to enhanced molecular potency. Additionally, the imidazopyrazine nucleus was compared to a known inhibitor of the Aurora Kinase enzyme, an important target in cancer therapy. Thus, strategic imidazopyrazines were subjected to comparative molecular dynamics calculations, providing inferences about their possible mechanisms of action. The QSAR model allows for the design and prediction of nine new analogues with favourable predicted IC50 values. Molecular dynamics simulations and the estimated binding energies are consistent with the ranking of activities presented by representatives of the series.
Mapping of the trans population in the Baixada Santista region, Brazil, 2023: a descriptive study
Authors: Barroso Barbara Iansã de Lima , Bassichetto Katia Cristina , Vieira Denise Leite , Gois Ísis , Rodrigues Julliana Luiz , Santos Naila Janilde Seabra , Souza Paola Alves de , Tayra Angela , Kumow Aline , Moreira Karin Di Monteiro , Maidel Fe , Veras Maria Amélia de Sousa Mascena , Dièguez Carla Regina Mota Alonso , Kruger Alícia , Ribeiro Maria Clara Gianna Garcia , Souza Rosa de Alencar , Luppi Carla Gianna
Published: January 2025

ABSTRACT Objective To describe the socioeconomic and demographic characteristics of the trans population in the Baixada Santista region, São Paulo state. Methods This was a descriptive study involving adult trans people, selected through convenience sampling in 2023. A quantitative questionnaire was administered and in-depth interviews were conducted, which were analyzed using thematic grouping. Results A total of 237 people were recruited. Of these, 42.2% identified as trans women/travestis and 36.3% as trans men/ transmasculine; 65.4% were aged up to 29 years; 51.1% self-identified as White race/skin color; 52.7% were single; 80.5% had completed at least high school; 32.5% reported no income. Self-perception of transgender identity occurred predominantly between the ages of 10 and 19 (55.7%), with social transition beginning between the ages of 15 and 19 (41.8%). Fourteen in-depth interviews were conducted. Conclusion Socioeconomic factors – education level, employment and income – are central to gender identity. Public actions and policies need to be developed and improved.
Role of the Transcription Factor FoxO in Type 2 Diabetes and Its Complications
Authors: Shi Jing Hui , Shi Yi Biao , Qiu Si Tian , Song Ying
Published: January 2025

FoxO proteins represent a subfamily of the forkhead box family (Fox) superfamily of proteins. It is involved in cell proliferation, differentiation, oxidative stress, apoptosis as well as tumors and metabolic disorders by regulating cellular functions. This paper aims to summarize the role of the transcription factor FoxO in type 2 diabetes and its complications, which may add to the potential of FoxO as a therapeutic target for future research. The transcription factor FoxO is expressed in various tissues and participates in various bodily functions including cell proliferation, differentiation, apoptosis, tumor therapy, and metabolic processes, playing a crucial role in the human body. FoxO plays a positive role in attenuating oxidative stress, inflammation, and metabolic disorders, which are the main causes of type 2 diabetes and its complications. FoxO plays an important role in the regulation of type 2 diabetes and its complications, and more precise targeting studies of FoxO will help to prevent, regulate, and treat diabetes-related diseases.
Sözeylem Anlama ve Üretim Becerisi: Bir Ölçek Geliştirme Çalışması
Authors: Yıldız Erol , Özdemir Selda
Published: January 2025

Dil sözel ve sözel olmayan öğeleriyle bireyin bilişsel, akademik ve sosyal-duygusal gelişiminde önemli etkiye sahip sosyal bir olgudur. Dolayısıyla hem tipik hem özel gereksinimli hem de özel yetenekli bireylerin sosyal ve duygusal gelişimlerine ilişkin kritik göstergeler sunabilmektedir. Bu çalışmada, sözeylem, yüz ve incelik kuramlarına dayalı olarak 8-14 yaş aralığındaki çocukların dolaylı sözeylem anlama ve üretme becerilerinin değerlendirilmesi için performansa dayalı bir ölçek geliştirilmiştir. Çalışma sonucunda Sözeylem Anlama ve Üretim Becerisi Ölçeği (SAÜBÖ) iki formdan oluşmuştur. Her bir formda anlama ve üretim olmak üzere iki faktör ve dokuzar madde yer almıştır. Her bir formun içerik, yapı ve ayırt edicilik geçerliliği ile güvenilirlik analizleri yapılmış ve çalışma bulguları geliştirilen ölçeğin her iki formunun da çocuklarda dolaylı sözeylem anlama ve üretme becerilerini değerlendirmede kullanılabileceğini göstermiştir.
Meslek Öncesi Öğretmen Yetiştirme Sürecinde Uygulamalı Derslerin Önemi ve İşlevleri Üzerine Aday Öğretmen Görüşlerinin Değerlendirilmesi
Authors: Göçer Ali
Published: January 2025

Öğretmen yetiştirme sürecinde verilen lisans eğitiminin gerçekleştirilme süreci, içeriği, önemi ve işlevleri düşünüldüğünde meslekle ilgili konuların pedagojik olarak içselleştirilmesi, kullanılabilir öğrenmelerin gerçekleşebilmesi ve kalıcılığının sağlanması için teorik pratik bütünlüğünün sağlanması önemli ve gereklidir. Bu kapsamda araştırmanın amacı, meslek öncesi öğretmen eğitimi sürecinde öğretmen adaylarının teorik bilgileri öğrenmeleri yanında öğrenilen bilgilerin uygulanabilirliğini sınama durumlarını ve bilgiyi beceriye dönüştürme açısından deneyim sahibi olup olmadıklarını ortaya çıkarmaktır. Bunun yanında adayların öğretmen yetiştirme sürecinde uygulamalı derslerin önem ve işlevlerine yönelik görüş ve beklentilerini ortaya koymaktır. Araştırma, nitel araştırma yöntemi tercih edilerek fenomenolojik araştırma deseni ile yapılandırılmıştır. Araştırmanın çalışma grubunu ERÜ Eğitim Fakültesi Türkçe Öğretmenliği programında öğrenim gören 55 Türkçe öğretmeni adayı oluşturmaktadır. Çalışmada veriler yarı yapılandırılmış görüşme formu ve görüşme soruları odağında yapılandırılarak iki oturumla gerçekleştirilen söyleşilerle elde edilmiştir. Elde edilen veriler içerik analizi tekniğiyle incelenmiştir. Araştırmada elde edilen verilerden ulaşılan bulgu ve sonuçlara göre, öğretmen adayları, nitelikli insanın nitelikli bir eğitim ile yetiştirilebileceği, nitelikli bir eğitimin de nitelikli bir öğretmen kadrosu ile sağlanabileceğinin farkındalığına sahiptirler. Öğretmen adayları mesleklerine hazırlanmalarında teorik-pratik bütünlüğünün sağlandığı uygulamalı eğitimin kazanımlarına yönelik farkındalıkları yüksektir. Öğretmen adayları, mesleklerine donanımlı bir şekilde hazırlanmalarında uygulamalı eğitimin eksik olduğu düşüncesindedirler. Adayların üstünde durdukları ve vurgu yaptıkları en önemli konu, öğretmenlik rollerini yerine getirme konusunda yeterli olmadıkları düşüncesiyle meslek öncesi öğretmenlik eğitiminde teorik derslerden ziyade uygulamalı dersler istemektedirler. Araştırma sonunda öğretmen adaylarının lisans eğitimlerinde mesleğe pedagojik olarak hazırlanmalarının sağlanmasında uygulamalı dersler konulup bu derslerin amacına ve anlamına hizmet edecek şekilde gerçekleştirilmesine yönelik birtakım önerilerde bulunulmuştur.
Distribuciones discretas de probabilidad: fórmulas de cálculo y problemas de aplicación
Authors:   Universidad Cooperativa de Colombia, Nova Martínez Manuel Arturo , Sorza Álvarez Elkin Giovani , Zabala Arango Lina María
Published: January 2025

Este documento proporciona una visión general de las distribuciones de probabilidad discretas, sus características y aplicaciones. Se exploran en profundidad las distribuciones binomial, Poisson e hipergeométrica, junto con sus respectivas fórmulas y propiedades. También se presentan algunos problemas comunes que pueden resolverse utilizando estas distribuciones, como el cálculo de la probabilidad de éxito o fracaso en experimentos binarios, la modelización de procesos de conteo y la predicción de eventos. Además, se contempla una introducción práctica a la implementación de estas distribuciones en el software R.
Programación en Excel y transposición a Civil 3D en modelamiento de alcantarillados
Authors:   Universidad Cooperativa de Colombia, Guzmán Paredes Yomaira , Rojas Cortázar Roberto Ricardo
Published: January 2025

El propósito de esta guía práctica es desarrollar las competencias en el uso y la aplicación de la herramienta Excel para permitir obtener variables alfanuméricas que se puedan transportar a AutoCAD-Civil 3D para trasladar los resultados obtenidos con relación a los perfiles y que se puedan observar tridimensionalmente. Esta guía práctica describe cómo crear un proyecto de planimetría constructiva a un modelamiento previo a su ejecución.
Suffocated But Screaming
Authors: Peirse Alison
Published: January 2025

This video essay explores how the ageing woman is made monstrous in kaibyō eiga (Japanese ghost cat films). The supporting statement reflects on the scholarly rationale for, and the making of, the video essay and then makes a case for its original contribution to horror studies and videographic criticism.
Did the CPA Shut the Bathroom Doors for Transgender and Non-Binary People? A Critical Legal Reflection of Section 9(2) of the CPA
Authors: Scott-Ngoepe Tshepiso , Van Dyk Obakeng
Published: January 2025

The Consumer Protection Act 68 of 2008 (CPA) introduced a variety of consumer rights that are intended to protect consumers in their engagement with suppliers. Amongst these rights is the consumer's right to equality in the consumer market. Section 8 of the CPA sets out practices that are considered to be prohibited discriminatory marketing practices; while section 9 of the CPA provides instances that constitute reasonable grounds for differential treatment in certain circumstances. In particular, section 9(2) of the CPA provides that a supplier may provide and designate facilities that are separate but equal for the exclusive use of each gender. Alternatively, the supplier is permitted to offer access to a facility to one gender exclusively. Over the years, the LGBTQI+ community has increased awareness around gender stereotypes; and stressed that not all persons conform to a binary-gender allocation. Therefore, the question that arises is whether section 9(2) of the CPA, in permitting the designation of facilities to exclusively one gender, is unfairly discriminating against transgender and non-binary persons and is therefore unconstitutional. To the extent that the provision is constitutional, the paper considers whether the continued practice of having gender-segregated bathrooms to the exclusion of transgender and non-binary persons is constitutional.
Reflecting on 2024 and looking ahead
Authors: Lambert Mike
Published: January 2025

No Abstract
El racismo escolar: debates educativos y crónicas
Authors: López-Fernández Juan Diego
Published: January 2025

Reseña del texto El racismo escolar: debates educativos y crónicas, de los autores José Antonio Caicedo Ortiz y Elizabeth Castillo Guzmán, publicado en Popayán: Editorial Universidad del Cauca, 2022, 186 p.
Profesorado y textos curriculares: deliberaciones sobre la enseñanza del espacio público
Authors: Cavieres-Fernández Eduardo , Ubilla-Sánchez Gerardo
Published: January 2025

Con ocasión del rol que cumplen los profesores en la acomodación de los textos curriculares a las necesidades de los estudiantes, la presente investigación tiene como objetivo analizar, el pensamiento de dos grupos de profesores chilenos de historia respecto a los contenidos de formación ciudadana referidos al espacio público presentes en el programa de estudio y los textos escolares establecidos para la asignatura de Educación y Ciudadanía de enseñanza secundaria. Por medio de dos estudios de caso, se subraya la tensión entre las comprensiones y experiencias de estos profesores y los contenidos de estos textos. Específicamente, critican un acento puesto en la institucionalidad del Estado que limita la comprensión del espacio público como espacio autónomo en donde los ciudadanos deben resolver los conflictos sociales, incluyendo aquellos entre la ciudadanía y el propio Estado. No obstante, lejos de descartar el uso de estos materiales, valorizan sus aportes en temas como la participación ciudadana en espacios territoriales locales, pues les ayudan a integrar una variedad de perspectivas a su enseñanza respecto de una temática que consideran compleja, pero que requiere ser discutida por los estudiantes como parte de su formación para la ciudadanía.
Multi-round smHCR-FISH for archaea v1
Authors: Xu Heng , Wang Fengping
Published: January 2025

Understanding archaeal gene regulation is technically challenging due to the difficulty of measuring gene expression in individual archaeal cells. Here, we develop a multi-round smHCR-FISH method to quantify the transcription of multiple genes in single cells of a methanogenic archaeon.
Subcultivo o Pase de Cultivos Celulares v1
Authors: Garcia Judit
Published: January 2025

Consiste en transferir células de un recipiente de cultivo a otro nuevo para mantenerlas en condiciones óptimas de crecimiento. Este proceso se realiza cuando las células alcanzan una confluencia entre el 70% u 80%.