bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship of Sleep Duration, Excersise Habits, Physical Activity and Eating Frequency to Nutritional Status of Students of SMAN 22 Surabaya During The Pandemic Covid-19
Authors: Zuhar Reza Farhana
Published: November 2022

Background: The COVID-19 pandemic that has spread throughout the country has caused changes in behavior patterns due to social restrictions. This has resulted in activities outside the home and in open spaces being limited and even abolished and replaced with online activities (in the network). Students who usually take part in teaching and learning activities and do sports and extracurricular activities that they like at school turn into online activities at home. Teenagers cannot socialize with their friends and their space becomes limited during the Covid-19 pandemic so they tend to play social media and get a lot of sleep disorders and experience depression. In addition to changing activities, adolescents' eating patterns and sleep duration also change due to changes in daily routines. This condition affects the nutritional status of adolescents.Objectives: This study was conducted to analyze the relationship between sleep duration, exercise habits, physical activity and eating frequency with the nutritional status of the students of SMAN 22 Surabaya.Method: This research is an analytical observational study conducted at SMA Negeri 22 Surabaya with 170 respondents aged 15-17 years. The measurements taken included the respondent's nutritional status, anthropometry, sleep duration, exercise habits, physical activity and adolescent eating frequency during the pandemic. Statistical analysis used to test the hypothesis of this study using the chi-square test.Result: The nutritional status of non-obese as many as 94 students, and nutritional status of obesity as many as 76 students. Respondents with short sleep duration were 53 students, adequate sleep duration was 105 students, and long sleep duration was 12. Respondents with regular exercise habits were 45 students, and non-routine exercise habits were 125 students. Respondents with light physical activity were 75 students, moderate physical activity was 49 students, and high physical activity was 45 students. Respondents with low eating frequency were 113 students, 37 students had moderate eating frequency and 20 students had high meal frequency.Conclution: nutritional status is related to sleep duration, exercise habits, and eating frequency during the pandemic.
Strategi Pemasaran di RSI Surabaya Ahmad Yani Berdasarkan Pendekatan New Wave Marketing
Authors: Masithoh Annisa Alfinur
Published: November 2022

Latar Belakang:Penurunan jumlah kunjungan pasien di rumah sakit merupakan salah satu tanggung jawab unit pemasaran. Oleh karena itu, salah satu cara yang dapat dilakukan untuk meningkatkan jumlah kunjungan pasien adalah dengan menyusun strategi pemasaran yang baik.Tujuan: Tujuan penelitian ini untuk menganalisis penerapan 12 elemen new wave marketing dan menjelaskan secara komprehensif analisis TOWS di RSI Surabaya Ahmad Yani sebagai upaya penyusunan strategi peningkatan jumlah kunjungan pasien.Metode: Jenis penelitian ini adalah deskriptif kualitatif dengan metode in-depth interview dan analisis data sekunder.Hasil: Hasil penelitian menunjukkan bahwa RSI Surabaya Ahmad Yani telah menerapkan konsep pemasaran 12 elemen new wave marketing dalam kegiatan pemasarannya. Dari hasil temuan isu strategis dan analisis TOWS, diketahui bahwa ancaman terhadap RSI Surabaya Ahmad Yani berada pada elemen coding dan commercialization, untuk peluang terdapat pada elemen clarifying; co-creation; currency; conversation; dan collaboration, untuk kelemahan terdapat pada elemen confirming; communal activation; dan caring, serta untuk kekuatan terdapat pada elemen communitization dan character. Posisi RSI Surabaya A. Yani sendiri berada pada kuadran satu diagram TOWS, sehingga dari hasil temuan tersebut dapat disusun strategi pemasaran yang sesuai.Kesimpulan: Kesimpulan dari penelitian ini secara umum adalah pada tiap elemen new wave marketing terdapat berbagai hal yang dapat menjadi ancaman, peluang, kelemahan, dan kekuatan rumah sakit.
Literature Review: Overview of Heavy Metal Contamination of Shrimp in Indonesia
Authors: Milati Zida Sinata
Published: November 2022

ABSTRAK

 

Latar Belakang : Udang merupakan salah satu sumber protein hewani yang bergizi dan memiliki banyak manfaat bagi tubuh. Produksi udang di Indonesia menjadi salah satu dari 10 penghasil udang utama dunia, hal ini sejalan dengan meningkatnya konsumsi ikan, utamanya udang pada masyarakat Indonesia. Udang yang hidup di air tawar maupun di air laut selalu mencari makan di dasar air yakni pada sedimen, yang mana banyak terendap partikel-partikel padatan berupa pasir dan lumpur serta logam berat sebagai akibat proses pengendapan di perairan, sehingga udang merupakan indikator yang baik untuk polusi logam berat. 

Tujuan : Tujuan penulisan literatur review ini adalah untuk menggambarkan kondisi cemaran logam berat pada udang di Indonesia. Oleh karena itu, perlu dilakukan pemantauan konsentrasi cemaran logam berat pada udang, sehingga dapat memberikan sinyal peringatan kepada masyarakat apabila kadarnya melebihi ambang batas (Zodape, 2014).

Metode : Metode yang digunakan dalam penulisan artikel ini adalah Literatur Review yaitu penelitian dengan melakukan telaah terhadap beberapa artikel nasional maupun internasional. Database yang digunakan berasal dari Google Scholar dengan menggunakan kata kunci terkait dan didapatkan 2160 artikel, setelah dilakukan screening topik dan kriteria inklusi yang telah ditetapkan, didapatkan 13 artikel yang selanjutnya dilakukan Literatur Review.

Ulasan : Uji kandungan logam berat (Hg, Pb, Cu, Cr, As, Mn, dan Zn) pada udang di beberapa wilayah di Indonesia baik menggunakan metode uji AAS (Atomic Absorption Spectrophotometer) maupun uji warna (Rapid Test Kits) menghasilkan beberapa variasi, untuk sampel udang yang diuji kandungan cemaran logam berat Hg, Cu, Mn, dan Zn pada semua sampel aman, sedangkan sampel udang yang diuji kandungan Pb, Cd, dan Cr terdapat hasil positif dan negatif (perbandingan  1 : 2).

Kesimpulan : Terdapat variasi hasil kandungan logam berat (Hg, Pb, Cd, Mn, Cu, As, dan Zn) pada sampel udang dengan di beberapa wilayah di Indonesia. Sampel udang yang positif maupun negatif logam berat tertentu, dapat dipengaruhi oleh beberapa faktor. Masyarakat dihimbau tetap terus berhati-hati yakni dengan selalu mengolah udang sebelum dikonsumsi dengan baik dan benar.

 

Kata Kunci : Cemaran, Logam Berat, dan Udang
The Effect of Berberine on the Prevention and/or Treatment on Cyclophosphamide-Induced Testicular Damage in Rats
Authors: ALTUNTAŞ Hakan , ÖZDEMİR Mahmut , HARMANCI Nuşin , YİĞİTASLAN Semra , ŞAHİNTÜRK Varol
Published: November 2022

The protective and/or therapeutic effect of berberine on cyclophosphamide-induced testicular injury was investigated in rats. A total of 40 male Sprague-Dawley rats were divided into 5 groups (n=8 per group). The control group received saline and CP, BER75, BER150 and BER300 groups received single dose of intraperitoneal 200 mg/kg CP on day 8. Berberine (75 mg/kg, 150 mg/kg and 300 mg/kg) was administered orally for 7 days before and after the CP injection. At the end of the protocol, testes were removed for histological examination, immunohistochemical staining, and biochemical assessments. In our study, CP did not cause a significant change in body weight and testis weight, whereas berberine treatment significantly decreased body weight. Although no significant change was observed in terms of oxidative stress markers and cytokine levels, degenerative changes and apoptotic findings were found in the CP group; which were improved significantly with increasing doses of berberine treatment. In conclusion, we found that treatment with berberine may have anti-degenerative and anti-apoptotic potential rather than altering oxidative stress markers and/or inflammatory pathways in CP-induced testicular damage.
Studi Metode Perhitungan Fluktuasi Pemakaian Air di Apartemen Tanpa Jam Pemompaan
Authors: Marcell Laurensius , Hadisoebroto Rositayanti , Tazkiaturrizki Tazkiaturrizki
Published: November 2022

Perencanaan apartemen meliputi perencanaan ukuran reservoir dan sistem pemompaan untuk reservoir serta sistem distribusinya. Dalam menentukan ukuran optimal untuk reservoir dibutuhkan data pembanding dari apartemen lain dengan spesifikasi yang relatif sama. Data tersebut diolah untuk menentukan jumlah pemakaian air maksimal dan minimum rata-rata dalam periode waktu tertentu. Ukuran reservoir optimum dapat ditentukan berdasarkan hasil pengolahan data tersebut. Sehingga metode perhitungan fluktuasi pemakaian air diperlukan untuk menentukan hal tersebut, namun tidak setiap apartemen memiliki kesamaan dalam sistem pemompaannya. Penelitian ini ditujukan untuk pengambilan data di apartemen yang tidak memiliki jam pemompaan yang pasti. Hasil studi menunjukkan bahwa metode yang digunakan dapat berlaku untuk apartemen tanpa jam pemompaan.
IDENTIFIKASI KONTEN DEWASA PADA CUITAN TWITTER MENGGUNAKAN METODE BILSTM SEBAGAI UPAYA MENGATASI PENYEBARAN PORNOGRAFI UNTUK INDONESIA MAJU
Authors:   Program Studi Informatika, Fakultas Teknologi Industri, Universitas Islam Indonesia, Perdana Hesaputra Akmal , Digo Saputra Rayhan ,   Program Studi Informatika, Fakultas Teknologi Industri, Universitas Islam Indonesia, Hudatama Wibowo Yafi ,   Program Studi Informatika, Fakultas Teknologi Industri, Universitas Islam Indonesia
Published: November 2022

Penggunaan bahasa dalam kehidupan merupakan suatu hal yang sangat mendasar, termasuk pada jejaring media sosial yang sudah menjadi sesuatu yang tak terpisahkan. Namun, banyak konten di media sosial berisi informasi yang tidak bermanfaat dan diperlukan dengan beredarnya konten-konten negatif dan berbahaya, seperti konten dewasa atau pornografi. Fungsi otak akan berubah pada seseorang yang memiliki kecanduan, salah satunya kecanduan konten pornografi. Maka dari itu, konten-konten dewasa tersebut merupakan ancaman serius yang dapat membahayakan generasi muda bangsa Indonesia, terutama anak-anak dan remaja yang merupakan cikal bakal menjadi tonggak bagi kemajuan dan pembangunan bangsa. Oleh karena itu, penelitian ini bertujuan untuk membangun model klasifikasi konten dewasa menggunakan algoritma Bidirectional Long Short Term Memory (BiLSTM) Neural Network untuk mengklasifikasi konten dewasa dan non-dewasa pada media sosial Twitter dengan memanfaatkan Twitter API dan library Tweepy. Berdasarkan percobaan, model terbaik diperoleh dari model BiLSTM Double layer dengan dropout yang memiliki Accuracy 98.34% dan F1-Score sebesar 98.32%. Kata kunci: Generasi Muda, Konten Dewasa, Twitter, Klasifikasi, BiLSTM
The Not-So-Silent Rise of Nationalism: A COVID-19 Result
Authors: Pulla Venkat Rao
Published: November 2022

Since the discovery and surge of the COVID-19 virus in the early days of 2020, we saw the creepy crawl of accusations and counteraccusations, the divisions between the scientific communities, the lack of exemplary conduct by the political elites, the lack of transparency in the reporting of death statistics, and the increasing lack of confidence and support for people. Amidst all this was a burgeoning of defensive and, on many occasions, offensive nationalism. A stage that mirrored resounding the amended final command from the 1924 George Orwell’s Animal farms, wherein the Pigs, the more intelligent of the manor farm animals, proclaim that some animals are more equal than others.
Unified program for predicting the spread of viral infections
Authors: Sudakov Vladimir Anatolievich , Sivakova Tatiana Vladimirovna
Published: November 2022

Over the past few years, in the context of the spread of coronavirus infection, the role of simulation has increased significantly. The development and implementation of multi-agent models in practice helps not only to predict the number of cases and predict possible peaks in incidence, but also serves as an assessment for taking the necessary measures to contain the spread of the virus, use personal protective equipment, and introduce restrictive measures related to the work of organizations and transport. The developed program for the spread of viral infections is built on the basis of meta-classes of objects and allows you to take into account a "large" number of contacts. The program was implemented on the example of the spread of coronavirus infection. OpenStreetMap (OSM) open data were used as geoservices for settlements.
Workshop Pelatihan Learning Management System (LMS) Untuk Peningkatan Kualitas Pembelajaran Jarak Jauh Di SMP Negeri 242 Jakarta
Authors: Hidayaht Achmad Nur , Kurniawan Nandi , Istiqomah Nurul
Published: November 2022

This community service activity is to provide training in designing online learning through the use of the Edmodo online platform for teachers of SMP Negeri 242 Jakarta. This is due to the Covid-19 pandemic which requires learning activities to be carried out from home (PJJ). The ability of teachers to utilize digital learning platforms by moving offline learning to online learning, as well as organizing student assignments into competencies that must be mastered and improved in order to create synchronous and asynchronous learning. The application of Edmodo is a learning alternative that creates effective learning to support the process of organizing learning activities because Edmodo has several features, such as "Assignment", "Quiz", and "Poll" and several other features such as cloud for material storage.

This training activity was attended by 26 teachers of SMP Negeri 242 Jakarta from various subject teachers. The training is carried out online and offline. The data acquisition instrument used a questionnaire which was used to determine the initial perceptions and insights of the training participants towards the BDR learning that had been carried out and to find out their perceptions and insights after attending the training. Based on the results of the questionnaire, the training that has been carried out has had a positive and beneficial impact on the teachers of SMP Negeri 242 Jakarta.
Oxfam Bangladesh Economic Justice and Resilience Pillar: Integrated impact evaluation report
Authors: Holland Jeremy
Published: November 2022

The Economic Justice and Resilience Pillar of the Oxfam Bangladesh Country Strategy 2016–19 was an ambitious and far-reaching portfolio of initiatives conducted across widely varying contexts and with a large cast of partners. This integrated evaluation report is the result of a rich study process that captured this ambitious complexity through a careful sequencing of mixed-method data collection and multi-stakeholder sense making and analysis. Despite the ambitious scope and challenging context, this report confirms that the Pillar has been highly successful and effective across several of its flagship projects. It reveals compelling evidence of economic empowerment of women and youth, emerging enterprises and value chains that create more highly skilled and capital-intensive opportunities for women producers, strengthened community-level climate resilience, and partnership strengthening at different levels. Find out more by reading the full report now.
A novel mineral composition increases soybean crop yield by mitigating stress induced by ultraviolet-A and -B radiation
Authors: Abreu André L. , Gratão Priscila L. , Rodriguez Carlos A.V. , Junior Gilmar S. Sousa
Published: November 2022

Ultraviolet radiation (UVR) is an important environmental abiotic stress that affects the yield potential of agricultural crops, and few practical solutions are available for protecting large-scale field cultivation. The present study assessed the protective effect of a novel mineral composition principally based upon microparticles of crystal and insoluble quartz sand applied over the top of plants to mitigate the stress effects of UV-A or UV-B radiation. Soybean (Glycine max (L.) Merrill) plants were cultivated under three alternative UVR exposure scenarios (no UV, +UV-A, +UV-B) to compare treated and untreated plants with that composition. Measurements of malondialdehyde (MDA) and proline contents demonstrated the effects of +UV-A and +UV-B on plants and the effectiveness of the foliar treatment in mitigating such stress. Biometric assessment showed that root weight, foliar biomass, and number of pods of untreated plants were negatively impacted by both +UV-A and +UV-B, whereas in treated plants, the damages for both +UV-A and +UV-B were almost entirely mitigated. The results of this study endorse the use of a promising tool for growers to achieve sustainable yield in soybeans and potentially other field crops in the face of increasing challenges due to climate change.
Non-lactational Breast Abscess due to Burkholderia Contaminans – Case Report of a Rare Organism with Rare Presentation
Authors: Pal Bishal , Dutta Souradeep , Jain Ankit , Anandhi Amaranathan
Published: November 2022

Introduction:
A breast abscess (BA) is a localized collection of purulent materials within breast tissues. BA are most frequently present during the lactational period, but they can rarely manifest in the non-lactational period. Staphylococcus aureus is the most common causative organism, mostly methicillin-resistant S. aureus, followed by coagulase-negative Staphylococci. Burkholderia contaminans is an uncommon opportunistic infection commonly associated with cystic fibrosis. BA due to a Burkholderia contaminans infection has never been reported previously.
Case Presentation:
We are reporting a 25-year-old immunocompetent woman with a non-lactational left BA caused by Burkholderia contaminans. She complaints of gradually progressive lump in her left breast for one year. Local examination revealed a tender swelling with induration and soft central region in the lower inner and outer quadrant suggestive of BA with palpable left axillary lymph node. She was successfully treated with ultrasound-guided needle aspiration followed by a course of culture-based antibiotics.
Conclusions:
Burkholderia contaminans is one of the 24 species in the Burkholderia cepacia complex (Bcc). Burkholderia contaminans is an extremely rare opportunistic pathogen with low virulence but extensive virulence factors. Bcc infection can vary from an asymptomatic carrier, chronic infection ranging from pulmonary involvement to invasive Bcc, and life-threatening presentation like cepacia syndrome, especially in CF and chronic granulomatous disease patients. In our patient symptoms of BA was chronic with recent aggravation. BA should be managed by incision and drainage or image guided needle aspiration, undercover of enteral or parenteral antibiotics depending upon severity of the disease.
Analysis of Genetic Diversity in Patients with Major Psychiatric Disorders versus Healthy Controls:
A molecular-genetic study of 1,698 subjects genotyped for 100 candidate genes (549 SNPs)
Authors: Stassen Hans , Bachmann Silke , Bridler René , Cattapan Katja , Hartmann Annette , Rujescu Dan , Seifritz Erich , Weisbrod Matthias , Scharfetter Christian
Published: November 2022

In this study we addressed the question of the extent to which irregularities in genetic diversity might separate patients with major psychiatric disorders from healthy controls.
Genetic diversity was quantified per gene through multidimensional “gene vectors” assembled from 4-8 polymorphic SNPs located within each of 100 candidate genes. The number of different genotypic patterns observed per gene was called the gene’s “diversity index”. Our sample was comprised of 1,698 subjects from Central Europe (1,431 psychiatric patients, 267 healthy controls), all genotyped for 549 specifically selected SNPs.

The evaluation of the diversity indices of the 100 candidate genes resulted in a mean value of 109.4±82.8, ranging from 18 to 476. Highly significant deviations from “normal” diversity values were detected for (1) major depression (n=596): a significant reduction (p<0.0001); (2) Alzheimer’s disease (n=75): a significant reduction (p<0.0001); and (3) schizoaffective disorders (n=64): a significant increase (p<0.0001). Almost one third of the genes were correlated with each other, with correlations ranging from 0.0303 to 0.7245.

The central finding of this study was the discovery of “singular genes” characterized by distinctive genotypic patterns that appeared exclusively in patients but not in healthy controls. In each of the diagnostic subgroups under study, there were no less than 45%-55% of patients who exhibited genotypic patterns of singular genes that did not at all show up in the healthy controls. Neural Net (NN) analyses enabled the construction of nonlinear classifiers that correctly identified up to 90% of patients in comparisons with healthy controls at false-positive error rates of zero percent. The NN analyses revealed considerable overlaps on the genotype level between the various clinically defined diagnostic subgroups, suggesting that diagnosis-crossing, unspecific vulnerabilities are likely involved in the pathogenesis of major psychiatric disorders.

Clinical applications of the proposed method are immediately possible and will facilitate the early detection of latent psychiatric disorders among risk cases, so that early interventions can be started before clinically relevant symptoms develop. A larger number of hospitalizations could be prevented in this way.
Clinical Profile and Outcomes of Congenital Cataracts at a Reference Center in Mexico
Authors: Irusteta Leire , Domene-Hickman Jorge , Zuñiga-Posselt Karla , Ramos-Barrera Emilia , Matiz-Moreno Humberto
Published: November 2022

Background: Congenital cataracts are the most common cause of preventable childhood blindness in the world. Treatment of congenital cataracts is among the most difficult and cost-effective interventions in ophthalmology. Our aim was to review a large cohort of patients under a 10-year period to gain a better understanding of multiple factors that influence the outcome of congenital cataracts.
Methods: Retrospective review of medical charts of all children with diagnosis of cataract between January 2009 and December 2019 conducted at Ophthalmology Institute “Conde de Valenciana”', Mexico City. Exclusion criteria were children with traumatic or metabolic cataracts, cataracts secondary to uveitis, cataracts associated with previous intraocular surgery or steroid use and patients with no surgical or follow up records. All patients underwent simple aspiration of lens material with coaxial irrigation-aspiration system. In some patients, additional anterior vitrectomy and posterior capsulorhexis was performed. In older children (usually > 3 months of age) an IOL was implanted.
Results: A total of 198 eyes of 132 children were analyzed. Median age at presentation was 5.09 years, SE +/- 4.48 years. It was found that the most common cause of congenital cataract was idiopathic 81.81% (N=108), the remaining 18.18% (N=24) was associated with some systemic disease. It was found a 3.5 higher risk of having bilateral cataracts if a systemic disease was present (p=0.01). The most frequent type of congenital cataract was nuclear in 30.1% (N=59), followed by total in 24.5% (N=48) and posterior polar in 14.3 (N=28). A 1.51 higher risk of presenting visual acuity worse than 1.00 LogMar (p=0.011) was found when the form of presentation was total cataracts. 100% of the patients underwent surgery. Only 7.5% (N=15) of the patients required a second surgical intervention. The initial surgical technique was not directly correlated to the requirement for a second surgery (Odds Ratio 0.097, p=0.356).
Conclusion: We present our approach to congenital cataracts; these findings provide suggestions for etiology and epidemiology of congenital cataracts and the factors that influence patient visual prognosis.
Investigation Into Explainable Recommender System as a Digital Tool for Enticing Customers
Authors: Ene Ugochukwu M. , Bakpo F. S
Published: November 2022

Economic melt-down and increased cost of operations have made Financial Institutions rely more on digital platforms to acquire customers. Financial Institutions must sell more products and services through digital platforms for customer acquisition. However, the right and personalized products have to be suggested in a manner that will entice customers. There is, therefore, the need for financial institutions to deploy explainable recommender systems. This paper investigated Explainable Recommender System (ERS) in the finance domain in two aspects: an investigation into existing and recent methods of enticing customers leveraging on explainable recommendations is presented, then a systematic review of published articles from 2018 to date in the finance domain. Based on this investigation, there was a need to find criteria for designing an ERS and its performance evaluation for efficient use. Despite the increasing research on ERSs, researchers should give more attention to evaluating these explanations for optimum performance.
Conditional Deletion of Neurexin-2 Alters Neuronal Network Activity in Hippocampal Circuitries and Leads to Spontaneous Seizures
Authors: Chen Lulu , Haile Mulatwa , Khoja Sheraz , de Carvalho Gregory , Hunt Robert
Published: November 2022

Neurexins (Nrxns) have been extensively studied for their role in synapse organization and have been linked to many neuropsychiatric disorders, including autism spectrum disorder (ASD), and epilepsy. However, no studies have provided direct evidence that Nrxns may be the key regulator in the shared pathogenesis of these conditions largely due to complexities among Nrxns and their non-canonical functions in different synapses. Recent studies identified NRXN2 mutations in ASD and epilepsy, but little is known about Nrxn2’s role in a circuit-specific manner. Here, we report that conditional deletion of Nrxn2 from the hippocampus and cortex (Nrxn2 cKO) results in behavioral abnormalities, including reduced social preference and increased nestlet shredding behavior. Electrophysiological recordings identified an overall increase in hippocampal CA3◊CA1 network activity in Nrxn2 cKO mice. Using intracranial electroencephalogram recordings, we observed unprovoked spontaneous reoccurring electrographic and behavioral seizures in Nrxn2 cKO mice. This study provides the first evidence that conditional deletion of Nrxn2 induces increased network activity that manifests into spontaneous recurrent seizures and behavioral impairments.
Targeting mTOR to overcome resistance to hormone and CDK4/6 inhibitors in ER-positive breast cancer models.
Authors: Rodriguez María Jimena , Perrone María Cecilia , Riggio Marina , Palafox Marta , Salinas Valeria , Elia Andrés , Salgueiro Natali , Werbach Andrea , Marks María Paula , Kauffman Marcelo A. , Vellón Luciano , Serra Violeta , Novaro Virginia
Published: November 2022

Resistance to therapy remains a major obstacle in cancer management. Although treatment with hormone and CDK4/6 inhibitors is successful in luminal breast cancer, resistance to these treatments is frequent, highlighting the need for novel therapeutic strategies to delay disease progression and improve patient survival. Here, we assessed the mechanisms of acquired resistance using T47D and MCF-7 tamoxifen- and palbociclib-resistant cell-line variants in culture and as xenografts, and patient-derived cells (PDCs) obtained from sensitive or resistant patient-derived xenografts (PDXs). In these, we analyzed the effect of specific kinase inhibitors on survival, signaling and cellular aggressiveness. We found that mTOR inhibition is more effective than PI3K inhibition in overcoming resistance, irrespective of PIK3CA mutation status, by decreasing cell proliferation and tumor growth, as well as reducing cell migration and stemness. Moreover, a combination of mTOR and CDK4/6 inhibitors may prevent pathway reactivation downstream of PI3K, interfering with the survival of resistant cells and consequent tumor escape. In conclusion, we highlight the benefits of incorporating mTOR inhibitors into the current therapy in ER + breast cancer. This alternative therapeutic strategy not only enhances the antitumor response but may also prevent pathway reactivation, delaying the emergence of resistance and tumor recurrence.
Possibility of surgical field contamination by the patient’s exhaled air: evaluation using a carbon dioxide imaging camera and particle counter
Authors: Morioka Masakazu , Takamura Yoshihiro , Miyazaki Hideki T , Gozawa Makoto , Yamada Yutaka , Komori Ryohei , Tanaka Kengo , Inatani Masaru
Published: November 2022

The coronavirus disease (COVID-19) pandemic has led to a dramatic increase in facemask use. Consequently, it has been reported that exhaled airflow toward the eyes can cause the dispersal of bacteria into the eyes, potentially increasing the incidence of postoperative endophthalmitis. In addition to wearing a facemask, gaps between the surgical drape and skin can also direct exhaled airflow toward the eyes. Here, we aimed to examine how the risk of contamination varies depending on the state of the drapes. We used a carbon dioxide imaging camera to visualize changes in exhaled airflow under different drape conditions and a particle counter to evaluate changes in the number of particles around the eye. The results revealed airflow present around the eye and a significant increase in the number of particles when the nasal side of the drape was detached from the skin. However, when a metal rod called “rihika” was used to create space above the body, the airflow and number of particles significantly reduced. Thus, if drape coverage becomes incomplete during surgery, exhaled airflow toward the eye may contaminate the surgical field. On hanging up the drape, airflow can escape in the direction of the body, potentially preventing contamination.
Disrupted Gray Matter Structural Networks between Active and Inactive Phases of Thyroid-Associated Ophthalmopathy
Authors: Luo Lihua , Wen Hongwei , Gao Lixin , Li Dongmei
Published: November 2022

Patients with thyroid-associated opthalmopathy (TAO) reportedly exhibit widespread morphological abnormalities in attention and default mode network (DMN) areas, but alterations in coordinated patterns of brain structural networks underlying TAO are still poorly understood. This study aims to investigate the disruptions in gray matter (GM) structural networks between TAO patients in active and inactive phases. We constructed subject-wise structural networks based on GM volumetric features for 37 active and 35 inactive TAO patients, and 23 healthy controls. Graph theory analysis was conducted to assess the alterations of global and regional network topological properties for TAO patients and their correlation with clinical characteristics. Compared with inactive TAO patients and controls, active TAO patients showed significantly decreased global/local efficiency, and significant altered nodal betweenness centrality (BC) in the visual, attention, DMN and sensorimotor areas. Intriguingly, the BC of left lingual gyrus was significantly negatively correlated with bilateral intraocular pressure, and medial superior/opercular inferior frontal gyrus was significantly correlated with anxiety and depression parameters. Our results suggest that TAO patients at different clinical stages have segregated disruptions in GM network topology, which may due to the visual function and psychological changes. These findings may provide new insights into the neurobiological mechanisms of TAO.
Long-term effect of Padua-Clinical Decision Support on thromboprophylaxis guideline adherence: a prospective cohort study
Authors: Jaspers Tessa , Woestenberg Sandra , Berg Roy van den , Maat Barbara , Khorsand Nakisa , Meijer Karina , Bemt Patricia van den
Published: November 2022

Background: Prescription of Low Molecular Weight Heparins according to the thromboprophylaxis guideline reduces the venous thromboembolism (VTE) incidence in non-surgical hospitalised patients with 80%. To increase guideline adherence, we previously implemented a Clinical Decision Support (CDS) rule based on the Padua score (hereafter: Padua-CDS) in our hospital.
Aim: To determine the effect of the Padua-CDS on thromboprophylaxis guideline adherence two years after implementation (T2), compared to pre-implementation (T0) and immediately after implementation (T1).
Methods: We performed a prospective cohort study in non-surgical patients and compared to previous measurements before and after implementation. Guideline adherence was assessed by calculating the Padua prediction and Improve bleeding score for each patient. Logistic regression analysis was used to analyse the results.
Results: 85 patients were included in T2, the same number of patients previously collected in T0 and T1. Guideline adherence was 81.2%, compared to 49.4% in T0 (OR 4.42, 95%CI 2.21-8.81) and 82.4% in T1 (OR 0.92; 95%CI 0.42-2.01). Guideline adherence in patients with a high VTE risk without bleeding risk was 90.7%, compared to 45.5% in T0 and 84.3% in T1.
Conclusion: Thromboprophylaxis guideline adherence was still significantly increased two years after implementation of the Padua-CDS, demonstrating a sustained effect.
Evaluation of the sodium concentration in the groundwater of the Aquifer Systems of the State of Rio Grande do Sul, Brazil
Authors: Jeske Tailana Bubolz , Reginato Pedro Antonio Roehe
Published: November 2022

Sodium in drinking water is not a health concern for most people, but may be an issue for someone with hypertension, congestive heart failure or on a sodium-restricted diet. This work evaluated sodium concentration data in wells of the main aquifer systems in the state of Rio Grande do Sul (RS) according to the potability standard established by Ordinance No. 888 of 2021 of the Brazilian Ministry of Health. Furthermore, an analysis of sodium concentrations in relation to to the recommendation of the U.S. EPA and other countries on sodium concentration in drinking water less than 20 mg/L for individuals on a sodium-restricted diet (500 mg/day). The human health risk of sodium was assessed by calculating the non-carcinogenic hazard quotient from the US EPA Human Health Risk Assessment. In all, 4,687 hydrogeochemical data from tubular wells that capture water in the Permian Aquitards (AP), Crystalline Basement Aquifer System (SAEC), Guarani Aquifer System (SAG), Coastal Quaternary Aquifer System (SAQC), Palermo - Rio Bonito Aquifer System (SAPRB) and Serra Geral Aquifer System (SASG). More than 100 wells exceeded the maximum allowable amount of sodium in water from Ordinance No. 888 of 2021 of the Brazilian Ministry of Health. All aquifer systems have more than 30% of wells with sodium values above the U.S. EPA recommendation on sodium concentration in drinking water less than 20 mg/L for individuals on a sodium-restricted diet (500 mg/day). Ten wells in RS showed indications of non-carcinogenic risk.
Self-injurious Behavior in Adolescence and Child Abuse: Exploratory Study in a City of the State of Rio De Janeiro, Brazil
Authors: Júnior Antônio Augusto Pinto , de Lima Claudia Henshel , Cassepp-Borges Vicente
Published: November 2022

This article discusses the results of a research on the characteristics of self-injury of adolescents in a city in the interior of the State of Rio de Janeiro, Brazil. The study was carried out with a sample of 50 subjects of both genders, aged between 10 and 16 years, denounced for the practice of self-mutilation by public schools. Interviews were conducted with the participants and their guardians, obtaining data on the characterization, motivation for the practice of self-injury, sociodemographic profile and applicable referrals made. Data analysis was performed by categorizing the interviews with a simple and relative frequency survey. Most participants were female (80.0%), with an average 12.8 years of age, living in monoparental homes (36.0%) exposed to domestic violence (32.3%) and/or child abuse condition (23.1%). The most common behavior was to cause self-injury using a sharp object (76.4%), mainly affecting arms, hands or wrists (72.0%), with such behavior lasting an average period of 10.9 months. In 40% of cases, parents or family members identified self-injury, but most participants (52.0%) were not referred for specialized treatment. It is concluded that, by knowing this type of self-harm, the design of effective prevention measures and assistance actions can be structured.
Limited value of Platelet-related markers in diagnosing periprosthetic joint infection
Authors: song zhenyu , Huang Jincheng , Wang Dong-hui , Wang Qingkai , Feng Jiawei , Cao Qianqian , Chen Xiao , Dai Zhipeng , Gao Zongyan , Jin Yi
Published: November 2022

Objective
To evaluate the diagnostic values of serum platelet count (PC), mean platelet volume ratio (MPV), platelet count to mean platelet volume ratio (PVR), platelet to lymphocyte ratio (PLR), platelet to neutrophil ratio (PNR), and PC/AGR in the diagnosis of periprosthetic joint infection.
Methods
The medical records were retrospectively analyzed of the 158 patients who had undergone hip or knee revisions from January 2018 to January 2021. Of them, 79 cases were diagnosed with PJI and 79 with aseptic loosening (AL). PJI was defined using the Musculoskeletal Infection Society criteria. The plasma levels of C-reactive protein (CRP), the erythrocyte sedimentation rate (ESR), the serum platelet count (PC), mean platelet volume ratio (MPV), platelet count to mean platelet volume ratio (PVR), platelet to lymphocyte ratio (PLR), platelet to neutrophil ratio (PNR), and PC/AGR in the 2 groups were recorded and analyzed. The receiver operating characteristic curve was used to calculate the sensitivity and specificity of each indicator. The diagnostic value for each indicator was calculated according to the area under the curve (AUC).
Results
The PC, PVR, PLR, and PC/AGR levels in the PJI group were significantly higher than those in the AL group (P < .001). The area under the curve of PC/AGR was 0.802, which was slightly lower than that of CRP (0.826) and ESR (0.846). ROC analysis for PC/AGR revealed a cut-off value at 160.63, which provided 84.81% sensitivity and 65.82% specificity for periprosthetic joint infections. The area under the curve of PLR and PC was 0.738 and 0.702. The area under the curve values for PVR, PNR, and MPV were 0.672, 0.553, and 0.544, respectively.
Conclusions
The results of this study suggest that PC, PLR, and PC/AGR values do not offer significant advantages over ESR or CRP values when employed for the diagnosis of PJI. PVR, PNR, and MPV were not reliable in the diagnosis of PJI.
Combination of intracardiac echocardiography and contact force sensing for left ventricular papillary muscle arrhythmias
Authors: Chen Tongshuai , chang lujie , Rong Bing , Zhang Kai , Fan Guanqi , Kong Jing , Ling Mingying , Kong Qingyu , MBBS Kellina Maduray , Zhao Cuifen , Zhong Jingquan
Published: November 2022

Objectives
Catheter ablation of ventricular arrhythmias (VAs) arising from the left ventricular (LV) papillary muscles (PM) is challenging. This study sought to address whether combination of intracardiac echocardiography (ICE) and contact force sensing (CFS) can improve acute and long-term ablation outcomes of left ventricular papillary muscle arrhythmias.
Methods and Results
From May 2015 to August 2022, a total thirty-three patients underwent catheter ablation for LV PM arrhythmias: VAs was located in anterolateral PM in 11, posteromedial PM in 22. Combination of intracardiac echocardiography (ICE) and contact force sensing (CFS) was used in 21 of the 33 procedures. The mean 6.93±4.91 lesions were used per patient and were comparable between the CFS/ICE and No ICE/CFS (4.90±2.23 vs. 10.17±5.89; P=0.011).The mean CF achieved in ICE/CFS group were 7.52±3.31g. Less X-ray time were used in combination group (CFS/ICE: 165.67±47.80 S vs. No ICE/CFS: 365.00±183.73 S; P<0.001). Acute success rate was 100% for ICE/CFS group (n=22) and 66.67% for No ICE/CFS group (n=8). VAs recurrence at 11.21±7.21 months follow-up was 14.2% for ICE/CFS group and 50.00% for No ICE/CFS group (P=0.04). No severe complications occurred in all patients.
Conclusion
Combination of intracardiac echocardiography (ICE) and contact force sensing (CFS) can provide precise geometries of cardiac endo cavitary structures and accurate contact information of catheter during ablation, which improved acute and long-term ablation outcomes. Routine adoption of this strategy should be considered to improve outcomes of LV PM VAs ablation.
Sr-Doped Zinc Phosphate Ceramic Nanoparticles for Bone Regeneration
Authors: huang shenghui , Liu Hanzhong , Li Jiachun , Chen Yingqi , Zhang Wei , Qian Junyu , Hu Yanqing , Wu Liang , Zhang Dongfeng , Yu Fei , Zeng Hui , Wan Junming
Published: November 2022

Background:Synthetic bioceramic repair materials have a broad application prospect in bone defect repair because of their excellent bone conductivity and bone induction.Znic Phosphate ceramic particles are commonly used as bone repair material, but there are still problems such as insufficient osteogenesis and potential biological toxicity.Strontium (Sr) has the function of enhancing bone strength. Even in a wide range of ions concentration, they still have a positive impact on osteogenic differentiation.we made a novel type of Sr doped Znic Phosphate ceramic nanoparticles to explore its role in bone regeneration.
Methods:Bioactive nanoparticles with Zn and Sr and phosphate (Zn2Sr(PO4)2) were prepared through high temperature solid state method. The characterization analysis for Zn2Sr(PO4)2 nanoparticles was confirmed by TEM observation, EDS mapping ,FTIR, XRD, and XPS .The concentration of released Zn2+,Sr2+ and PO43- was measured by ICP. In vitro,the toxic effect and osteogenic capacity of Zn2Sr(PO4)2 to MC3T3-E1 cells was measured.In vivo ,the ability to promote new bone formation of nanoparticles was tested in rat criticalsized supracondylar femur defect models.
Results: In vitro degradation result revealed that the bioactive Zn2+,Sr2+ and PO43- ions were released from nanoparticles in a sustained and stable manner in PBS at 25 oC up to 4 weeks. In vitro osteogenic promotive result showed that the 1/8-1/2 Zn2Sr(PO4)2 nanoparticles cell culture medium extraction,which was at a relatively low concentration, showed superior ability in promoting MC3T3-E1 cell proliferation, osteogenic differentiation, and biomineralization compared to other diluted extract groups and control groups. Finally, 2mg-8mg Zn2Sr(PO4)2 nanoparticles promoted more new bone formation when implanted in the critical sized femoral bone defect (3 mm in diameter) in the rat.
Conclusion:The data suggest that the fabricated Zn2Sr(PO4)2 nanoparticles could act as an attractive candidate for bone regeneration.Zn and Sr play a synergistic role in this process,which avoids potential toxic reactions.
Deciphering the broadband absorption of eumelanin in solution phase
Authors: Singh Abhishek , Mason Thomas , Freeman Benny , Izgorodina Ekaterina
Published: November 2022

Melanin, a bio-polymer responsible for visible pigmentation in the human body, works as a protective layer in our skin by absorbing UV radiation and efficiently dissipating it into heat, preventing DNA damage. The primary structure of eumelanin, one of the two main forms of melanin, is presumed to be a co-polymer of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole- 2-carboxylic acid (DHICA) monomers, with DHI being the major component. The solution phase investigation into the origin of broadband monotonic absorption spectrum of melanin has been unfolded through the polymerization of dopamine and L-DOPA, the molecular precursors of DHI and DHICA, respectively, in an ionic liquid (IL). This study reveals that the evolution of the electronic absorption spectrum of polymerized L-DOPA did not mimic the electronic spectrum of eumelanin, which was attributed to their inability to form stable redox states, as elucidated via structural characterization. Contrary to that, polymerized DA (pDA) mimics the eumelanin absorption spectrum, and the structural characterization of the polymerization process performed with 1H and 13C NMR and DOSY spectroscopy allowed us to identify chromophores responsible for the absorption profile of pDA. Furthermore, identified chromophores were subjected to quantum chemical calculations and their absorption spectra not only supported their presence in the experimental UV-Vis spectra but also allowed us to identify their gradual evolution during polymerisation. The knowledge of chromophores responsible for the optical properties of melanin will undoubtedly result in their increased application in functional materials.
Knowledge, Attıtudes and Behavıors of Somalia Female University Students about Cervıcal Cancer, Hpv and Hpv Vaccine: Cross-Sectional Study
Authors: ALTUNKUREK Şeyma Zehra , ŞAHİN Eda , Mohamed Samira Hassan
Published: November 2022

Background: Awareness and knowledge of cervical cancer and HPV are consistently poor in developing countries. In addition, there is insufficient evidence for young people's knowledge and understanding of cervical cancer, risk factors, screening and HPV vaccination in these countries. This study was conducted to determine the knowledge, attitudes and behaviors of students studying at a university in Somalia about cervical cancer and prevention methods.
Methods: This cross-sectional study was conducted among students of the Faculty of Health Sciences at a private university in Mogadishu, Somalia, between January to March 2021.
The sample of study consisted of a total of 220 female students. The data of the study were collected using a questionnaire consisting of 32 questions evaluating the knowledge and attitudes of the students about cervical cancer, HPV and HPV vaccine.
Results:In our study, 59.1% of the participants stated that they had heard of cervical cancer before, 69.1% did not know that it was fatal, 49.1% stated that it was preventable, 48.2% did not know the causes of cervical cancer, and 2.7% had a family history of cervical cancer. In addition, it was determined that 75.9% of the participants did not know that HPV caused cervical cancer. When the knowledge status of the participants about HPV and HPV vaccine was examined, it was determined that 55% of them had not heard of HPV before. When asked about the transmission ways of HPV; respectively, kissing (73.2%), sexual intercourse (58.2%) and using the things of individuals infected with HPV (41.8%). None of the participants had received the HPV vaccine. 72.3% of them stated that they did not have any information as the reason for not being vaccinated. 40.9% of the participants stated that both boys and girls should be vaccinated, and 63.6% stated that they did not know at what age they should be vaccinated. In addition, 71.4% stated that they did not know that the HPV vaccine protects against sexually transmitted diseases. The results show that there is a statistically significant relationship only between the economic situation and the awareness variable (p<0.005). It was concluded that the awareness of the participants, whose economic situation was good, was statistically high.
Conclusion: Our first study on the subject in Somalia, it has been revealed that the level of knowledge and vaccination rates of female university students studying in the field of health sciences about HPV vaccine, cervical cancer and prevention methods are insufficient. In future studies, the reasons for these inadequacies can be revealed with more comprehensive studies.