bluuebunny/crossref_metadata_2025 huggingface dataset:
Does The Consumption of Energy, Renewable Energy, Natural Resources and Emissions Affect Gross Domestic Product?: The Study of Southeast Asia
Authors: Firmansyah Muhamad Ferdy , Rusliana Nanang , Komaludin Ade
Published: October 2024

We face the challenges of economic growth productivity which still uses dirty energy and minimal efforts to cleaner energy transition. The debate on efforts to increase productivity by diverting dirty energy into clean energy while still preserving nature has long been discused. Southeast Asia is a region that has massive development potential with valuable natural resources facing regional threats in addition to decreasing environmental quality but also prosperity. This study aims to identify initial steps are needed to control energy consumption, which is still considered dirty, the extent of the scope of Southeast Asia's current clean energy transition and how emissions can be a determinant of the decline in regional economic produtivity. This is the first study to combine the Cobb-Douglass production function model with three models that focus on (1) energy consumption, (2) renewable energy and natural resources, and (3) emissions. The data used is secondary data for the period 2004-2018 sourced from the World Bank Development Indicator and ourworlddata.org. Panel data regression was used as an analytical technique. This study was conducted in the Southeast Asia region (with selected countries with developing economies and insutries, namely Indonesia, Malaysia, Thailand, the Philippines and Vietnam). The results of this study show that in the energy consumption model, only labor has a significant effect on GDP, in model B there is renewable energy consumption and the labor force which significantly affects GDP and in model C there are CO2 emissions and GHC emissions that affect GDP in the Southeast Asia region. This research will provide input to policy makers and growth analysts to form policies for sustainable economic development in Southeast Asia.
Review of Waste Management in Indonesian Small Islands in the Last Five Years (2018-2023)
Authors: Vitasari Vitasari , Syakti Agung Dhamar , Suryanti Ani , Viruly Lily , Jaaman Saifullah Arifin , Lestari Febrianti , Nevrita Nevrita , Azizah Diana
Published: October 2024

Indonesia is a maritime country composed of 16,771 islands consisting of large islands and small islands. One of the environmental problems that occur in small islands. Waste management is a shared focus because sources of water, soil and air pollution can come from waste. Waste management on small islands is very important because small islands have a much higher vulnerability than large islands.. This article aims to identify and analyze waste management in Indonesia's Small Islands and evaluate if its implementation has utilized the technology and concepts of the Industrial Revolution 4.0. Based on the findings of a review of 14 articles published from 2018-2023, with 15 islands as research objects, it was found that most of the small islands used as research objects had not managed their waste properly. The waste is eventually dumped into the sea. The unmanaged factor of this waste can be caused by the geographical conditions on the island which are bordered by the sea, the lack of waste management facilities, the limited land area on small islands and the low awareness and participation of the community in waste management. The rest, several islands have carried out the process of storage, processing, collection and destruction quite well. The waste is turned into handicrafts (bags and souvenirs), ecobricks, garden decorations and plant fertilizers for organic waste as well as the development of innovative waste into diesel fuel. Unfortunately, the intended application based on the Industrial Revolution 4.0 has not been reflected in waste management on these small islands. This is expected to be information and input for the government and managers as a model for other small islands in an effort to manage waste generation on the island's mainland and garbage contamination in the sea.
The War of Resistance Against Japan in PRC’s School Textbooks (1949–1982)
Authors: Yang Chan
Published: October 2024

This paper provides a comprehensive analysis of the portrayal of the War of Resistance Against Japan in the school history textbooks of the People’s Republic of China from 1949 to 1982, prior to the 1982 Textbook Incident. It starts by outlining the core narrative of the War of Resistance as depicted in these textbooks over the given period. Subsequently, the paper analyzes the shifts and continuities in this narrative over the designated period. Subsequently, it concludes that the Chinese Communist Party regime exhibited a preference for portraying the war as a tragically heroic struggle led by the party. Furthermore, it argues that both the War of Resistance itself and its tragic elements played significant roles in the regime’s endeavors in nation-building prior to 1982.
Strategies to verify equimolar peptide release in mass spectrometry-based protein quantification exemplified for apolipoprotein(a)
Authors: van der Burgt Yuri E.M. , Romijn Fred P.H.T.M. , Treep Maxim M. , Ruhaak L. Renee , Cobbaert Christa M.
Published: October 2024

Objectives

Quantitative protein mass spectrometry (MS) is ideally suited for precision diagnostics and for reference standardization of protein analytes. At the Leiden Apolipoprotein Reference Laboratory we apply MS strategies to obtain detailed insight into the protein-to-peptide conversion in order to verify that quantifier peptides are not partly concealed in miscleaved protein backbone.

Methods

Apolipoprotein(a) (apo(a)) was digested in a non-optimal manner to enhance the number of miscleaved peptides that were identified by high resolution liquid chromatography tandem-MS measurements. The protein-to-peptide conversion was carefully mapped with specific attention for miscleaved peptides that contain an apo(a) quantifier peptide. Four different isotopologues of each apo(a)-quantifier peptide were applied to evaluate linearity of internal peptide standards during measurement of specific real-life samples.

Results

Two apo(a) quantifier peptides that were concealed in two different miscleaved peptides were included into a multiple reaction monitoring list in our targeted MS-based apo(a) quantifications to alert for potential protein digestion discrepancies. The presence of miscleaved peptides could be ruled out when applying our candidate reference measurement procedure (RMP) for apo(a) quantification.

Conclusions

These data further corroborate the validity of our apo(a) candidate RMP as higher order method for certification of commercial Lp(a) tests that is endorsed by the International Federation of Clinical Chemistry and Laboratory Medicine. MS-based molecular detection and quantification of heterogeneous apo(a) proteoforms will allow manufacturers’ transitioning from confounded lipoprotein(a) [Lp(a)] mass levels into accurate molar apo(a) levels.
Tensile strength of friction stir additive manufactured laminated AA 6061/TiC/GS composites
Authors: Maurya Manish , Maurya Ambrish , Kumar Sudhir
Published: October 2024

With the fast progress of industrial manufacturing, friction stir additive manufacturing has fascinated wide-ranging consideration in the industry due to high material consumption rate. Friction stir additive manufacturing (FSAM), a newly developed solid-phase additive manufacturing technique was employed to fabricate AA6061/TiC/GS composite. The process parameters like tool rotational speed, transverse speed, tool tilt angle and type of tools used in friction stir additive manufacturing were analyzed. Taguchi’s L16 orthogonal array and ANOVA method was used to find the optimum process parameters for the tensile strength. Development characteristics of stirred zone, recrystallization and mixing of reinforced particles will significantly improve the mechanical properties of the fabricated composites. Microstructural investigation and fractography was done by using optical microscopy and scanning electron microscopy (SEM). Corrosion, wear behavior and elemental analysis through EDS was also performed for the fabricated material. The maximum tensile strength of 385.74 MPa was attained under optimal parameters of the tool rotational speed 1,200 rpm, transverse speed 55 mm min−1, and tool tilt angle of 1° for scrolled tapered octagonal tool pin. The findings of the linear regression model showed a minor variance between model and experimental values. Prominent results of the experiment were compared by few other researcher’s findings working in similar area.
Microstructure and mechanical properties of Al2O3/AZ61 Mg alloy surface composite developed using friction stir processing and groove reinforcement filling processes
Authors: Ashokkumar Mohankumar , Sonar Tushar , Thirugnanasambandam Arunkumar , Vignesh Packkirisamy , Ivanov Mikhail
Published: October 2024

In this work, the alumina (Al2O3) particles-reinforced AZ61 magnesium (Mg) alloy surface composite was fabricated using friction stir processing (FSP) and groove reinforcement filling methods. The Mg alloy surface composites were developed with and without the addition of Al2O3 reinforcing particles, and their mechanical performance was compared with each other and with unprocessed base metal (BM). The Al2O3 powder was compressed into a groove of 4.5 mm depth that had been created in AZ61 Mg alloy plates. The volume fraction of Al2O3 powder was increased to 5, 10, and 15 vol.% depending on the width of the groove. Results disclosed that the problem of cluster formation of reinforcing Al2O3 particles was minimized by performing FSP in five number of passes. The ultimate tensile strength (UTS) and hardness of AZ61 Mg alloy were enhanced by 6.07 % and 22.23 % when it was subjected to FSP. This is primarily correlated to the significant refining of grains due to the severe plastic deformation associated with FSP. The 15 vol.%-FSPed Al2O3/AZ61 Mg alloy surface composite showed a higher UTS of 630 MPa and hardness of 300 HV. This is due to the integration of a greater quantity of Al2O3 particles with substantial grain refining.
Integrating Environmental, Social and Governance (Esg) Principles into Organisations
Authors: Paužuolienė Jurgita , Derkach Vadym
Published: October 2024

The term ESG, which stands for Environmental, Social and Governance, has gained significant traction in the business world. A
company’s dedication to ESG reflects its awareness of both the positive and negative impacts it has on society and the environment,
influencing not only the business itself but the entire ecosystem around it. Organisations that embrace the ESG framework recognise
that adopting best governance practices leads to positive outcomes across all sectors. This approach helps minimise the environmental
impact and fosters a more equitable world, while maintaining sound administrative processes and sustaining profitability. Incorporating
ESG factors into operations is essential for ensuring long-term sustainability, compliance and competitiveness. By focusing
on environmental stewardship, fostering positive social impacts and maintaining strong governance structures, organisations can
minimise their negative externalities, meet regulatory demands, and appeal to a growing number of ESG-conscious stakeholders.
The main aim of this article is to analyse the ESG principles, and present examples of integrating ESG in large and SMEs companies.
These organisations were chosen as examples of good practice: Maersk, Nestlé, Toyota, Baltic Marine Bunker and Klaipėdos Nafta.
The companies in this article were chosen to show a diverse range of industries and approaches to ESG implementation.
The use of metabolomics and machine learning algorithms to predict post-transplant diabetes mellitus in renal transplant patients on Tacrolimus therapy
Authors: Burghelea Dan , Moisoiu Tudor , Ivan Cristina , Elec Alina , Munteanu Adriana , Tabrea Raluca , Antal Oana , Kacso Teodor Paul , Socaciu Carmen , Elec Florin Ioan , Kacso Ina Maria
Published: October 2024

Background and aim. Tacrolimus (TAC) has significantly improved kidney graft survival following transplantation, though it is associated with adverse side effects. The most prevalent complication resulting from excessive TAC exposure is the onset of de novo diabetes mellitus (DM), a condition that can negatively impact both renal graft function and patient outcomes. De novo DM is linked to an increased risk of chronic transplant dysfunction, as well as cardiovascular morbidity and mortality. Although the underlying mechanisms remain unclear, emerging research in the field of omics shows promise. The aim of this study was to investigate the metabolomic profile of kidney transplant patients who developed de novo DM, in comparison to those who did not, following TAC exposure, using untargeted metabolomic analysis through ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS) and machine learning algorithms.
Methods. A cohort of 34 kidney transplant patients on a Tacrolimus regimen for at least 6 months was enrolled in the study, with serum samples collected from each patient. Comprehensive profiling of serum metabolites was performed, enabling the classification of patients into de novo diabetes mellitus and non diabetes groups. The metabolomic analysis of serum was conducted using UHPLC-MS.
Results. Of the 34 patients, 16 were diagnosed with TAC-induced diabetes. A total of 334 metabolites were identified in the serum samples, of which 10 demonstrated a significant correlation with the de novo diabetes mellitus group. Most of these metabolites were linked to alterations in lipid metabolism.
Conclusion. The application of metabolomics in kidney transplant patients undergoing a Tacrolimus regimen is both feasible and effective in identifying metabolites associated with de novo diabetes mellitus. This approach may provide valuable insights into the metabolic alterations underlying TAC-induced diabetes.
Personalized and predictive strategies for diabetic foot ulcer prevention and therapeutic management: potential improvements through introducing Artificial Intelligence and wearable technology
Authors: Ardelean Andrei , Balta Diana-Federica , Neamtu Carmen , Neamtu Adriana Andreea , Rosu Mihai , Totolici Bogdan
Published: October 2024

Diabetic foot ulcers represent a serious and costly complication of diabetes, with significant morbidity and mortality. The purpose of this study was to explore advancements in Artificial Intelligence, and wearable technologies for the prevention and management of diabetic foot ulcers. Key findings indicate that Artificial Intelligence-driven predictive analytics can identify early signs of diabetic foot ulcers, enabling timely interventions. Wearable technologies, such as continuous glucose monitors, smart insoles, and temperature sensors, provide real-time monitoring and early warnings. These technologies promise to revolutionize diabetic foot ulcer prevention by offering personalized care plans and fostering a participatory healthcare model. However, the review also highlights challenges such as patient adherence, socioeconomic barriers, and the need for further research to validate these technologies’ effectiveness. The integration of artificial intelligence and wearable technologies holds the potential to significantly improve diabetic foot ulcer outcomes, reduce healthcare costs, and provide a more proactive and personalized approach to diabetic care. Further investments in digital infrastructure, healthcare provider training, and addressing ethical considerations are essential for successful implementation.
Evaluation of oxidative stress biomarkers for differentiating bacterial and viral infections: a comparative study of glutathione disulfide (GSSG) and reduced glutathione (GSH)
Authors: Milhelm Zaki , Zanoaga Oana , Pop Laura , Iovita Andrada , Chiroi Paul , Harangus Antonia , Cismaru Cristina , Braicu Cornelia , Berindan-Neagoe Ioana
Published: October 2024

Background and aims. This study evaluates the potential of oxidative stress biomarkers, specifically glutathione disulfide (GSSG) and reduced glutathione (GSH), for differentiating bacterial and viral infections. Oxidative stress plays a crucial role in the immune response, and glutathione is a key regulator of cellular redox balance. The aim was to assess whether differences in GSH and GSSG levels could be used as diagnostic markers for infection type.
Methods. A chemiluminescence-based method evaluated GSH and GSSG as potential biomarkers for distinguishing between bacterial and viral infections. The GSH and GSSG concentrations were analyzed across bacterial, viral, and control groups.
Results. Our data revealed significant differences in the GSH/GSSG ratio between the analyzed groups, with bacterial infections showing higher oxidative stress markers compared to viral infections. A combined analysis of GSH and GSSG concentrations, visualized through heatmaps and ROC curves, improved diagnostic accuracy, with clustering patterns distinguishing infection types.
Conclusions. These findings suggest that the GSH/GSSG ratio could be used as a biomarker in distinguishing between bacterial and viral infections, offering potential clinical applications for more accurate diagnosis. Further research is required to validate these results in larger cohorts and to explore the underlying mechanisms of oxidative stress in pathogen-specific immune responses.
JUSTIFICATION OF THE EXTENDED COMPOSITION OF OBSERVATIONS AT WATER BALANCE STATIONS AND RESEARCH HYDROGEOPHYSICAL RANGES
Authors:   Institute of Geological Sciences of the National Academy of Sciences of Ukraine, Bublyas Volodymyr , Shevchenko Oleksii ,   Ukrainian Hydrometeorological Institute, Kyiv
Published: October 2024

The current level of understanding of the subordination and multifactorial dependence of the determining processes in the atmosphere, lithosphere and hydrosphere of the Earth requires a corresponding reorganization of the basic system of environmental monitoring, improvement and expansion of research on water these stations, which can become the supporting 'nodes' of the balance of this system. The appearance of fundamentally new theoretical developments, modern devices and equipment, a large number of software tools, etc., prompts a significant reorganization and strengthening of the environmental monitoring system. The article substantiates an additional set of studies, which should be included in the regulation of observations at already existing water balance stations, with their mandatory modernization. Spheres are subject to control - the atmosphere, surface and underground (subsurface) hydrospheres, which change over time at different rates and pedosphere. A certain inertia of hydrogeological processes implies the possibility of using meteorological indicators, which can be used to predict changes in the moisture regime in the aeration zone and shallow groundwater in the near future; based on the reliably predictable changes of the latter - to forecast changes in interlayer groundwater resources, etc. It is proposed to include in the monitoring regulations the following indicators of the state of the environment, which will allow to identify and analyze the causes of changes in the water situation, balance and resources, to determine the mechanisms of moisture transfer and accumulation, as well as to build models and perform predictive assessments. The results of comprehensive research at the «Lutiz» landfill demonstrate significant variability of hydrogeophysical indicators and changes in the intensity of natural signals depending on the landscape timing, the latest tectonics, the geological basis and the composition of the overlying sediments. Original devices are presented, which are used to determine indicators of electric and thermal fields, the ratio of positive and negative air ions, etc.
Chemical composition of sausages processed with starter cultures Lactobacillus curvatus and Lactococcus lactis subsp. lactis during storage in vacuum packaging
Authors: Lokes S. I. , Shevchenko L. V. , Mykhalska V. M. , Poliakovskyi V. M. , Chepil L. V.
Published: October 2024

Sausages belong to the category of cooked meat products with a short shelf life, which is associated with their rapid spoilage and unsuitability for consumption. One of the ways to extend the shelf life of sausages is the use of biopreservatives, including cultures of lactic acid bacteria. The aim of the study was to determine the chemical composition and organoleptic characteristics of "Juicy" sausages processed with a starter culture of Lactobacillus curvatus or a mixture of starter cultures Lactobacillus curvatus + Lactococcus lactis subsp. lactis before vacuum packaging and storage in a chilled state. Storage of sausages in the control variant in vacuum packaging in a chilled state for up to 18 days did not affect the moisture, protein, fat, and ash content, but on the 21st day, their spoilage was observed in the form of appearance of cloudy juice, sliminess, sour odor, and delamination of the vacuum packaging. Processing sausages with a starter culture of Lactobacillus curvatus or a mixture of starter cultures Lactobacillus curvatus + Lactococcus lactis subsp. lactis before vacuum packaging did not affect the moisture, protein, fat, and ash content up to 30 days of storage in a chilled state. On the 36th day, spoilage of sausages was observed in both variants of treatment with lactic acid bacteria cultures, characterized by the appearance of cloudy juice, sour odor, and delamination of the vacuum packaging. The pH value of sausages in both variants of treatment with lactic acid bacteria cultures decreased throughout the storage period and reached a level of 6.05 and 5.91 units on the 30th day. Processing sausages with either a single culture or a mixture of lactic acid bacteria cultures extends their shelf life in a chilled state by 12 days. The obtained results may justify the use of microbial biopreservatives for the production of cooked sausage products, which will help reduce losses due to spoilage during storage in vacuum packaging in a chilled state. The use of a mixture of lactic acid bacteria cultures for processing sausages requires further research and may be effective in case of detection of aerobic spoilage microorganisms.
Biochemical indicators of pig blood when using a complex probiotic feed supplement
Authors: Ibatullin І. І. , Tsereniuk О. М. , Zinoviev S. H. , Pushkina M. L. , Slynko V. H. , Stadnytska O. I. , Vashchenko P. A.
Published: October 2024

The use of probiotics in animal feed is one of the most promising alternatives to the application of antibiotics. In order to establish the effectiveness of the use of a complex probiotic supplement (Lactobacillus spp., Lactococcus spp., Spirulinaceae, Saccharomyces cerevisiae, Actinomycetaceae, Aspergillus spp. and Penicillium spp.) in pig farming, two groups of pigs of the Poltava Meat breed were formed by the analog method. In the ration of the fattening pigs of the experimental group, 1.0% of the mass of compound feed was replaced with a complex probiotic supplement, which was fed during the 45 days of the experimental period at the age of 135 to 180 days. In experimental pigs, biochemical blood parameters were determined (the content of protein, lipids, cholesterol, triglycerides, activity of aspartate aminotransferase and alanine aminotransferase, the content of creatinine, glucose, calcium, phosphorus, albumins and globulins) using test kits from the company "Filisit Diagnostics" (UA). As a result of the research, it was established that with the use of a complex probiotic feed supplement, the content of total protein in the blood serum of the pigs of the experimental group was higher by 18.4%, glucose by 21.4%, aspartate aminotransferase activity by 20.4%, alanine aminotransferase by 38.0% compared to control group. In both groups, regardless of the established difference, the named indicators were within the physiological norm. The concentration of cholesterol in the blood of pigs receiving the probiotic supplement decreased by 43.2%, but the concentration of calcium (by 26.2%) and phosphorus (by 17.9%) increased. In the experimental group, the blood indicators related to the immunity of pigs improved – the content of α1 and α2 globulins decreased by 4.1% and 7.4%, respectively. Also, in the experimental group, the concentration of albumins increased by 7.5%, which probably indicates an improvement in the functional state of the liver. As a result of feeding with a complex probiotic supplement in the experimental group the albumin-globulin ratio improved, which increased by 35.0%. Thus, the introduction of a complex probiotic feed additive into the ration of pigs changed the structure of the influence of exogenous and endogenous factors on metabolism, had a positive effect on the protein profile of the blood, and caused an increase of average daily gains in experimental animals by 5.8% compared to the control group.
Features of Proteus mirabilis clinical isolates and genetic relations inside the group
Authors: Yaseen H. S. , Thweni Q. N. , Jassim Z. M.
Published: October 2024

Proteus mirabilis, a bacterium causing urinary tract infections and exhibiting multidrug resistance, poses challenges in treatment and infection control. Molecular typing methods aid in understanding genetic diversity and relationships among isolates. Repetitive Intergenic Consensus ERIC-PCR and Random Amplified Polymorphic DNA (RAPD) are considered some of the rapid and simple genetic tests. The aim of the current study was to determine the differential ability of RAPD and ERIC-PCR in biotyping P. mirabilis isolated from clinical samples. This study was conducted in Al-Diwaniyah Governorate, Iraq, between 2023 and 2024. A total of 189 samples were collected from wounds, burns, stools, and urine from patients hospitalized in several hospitals in the city of Diwaniyah (Iraq). From these samples, twenty isolates of P. mirabilis were isolated and initially diagnosed using biochemical tests. Then the diagnosis was confirmed using the VITEK system 2. Bacterial resistance to antibiotics was assessed using the VITEK system 2, then an examination of the bacteria’s ability to produce biofilm was performed, following which the genomic DNA was extracted from the bacteria, and the ERIC and RAPD tests were performed. The differential ability of RAPD and ERIC-PCR was evaluated based on the Simpson's Index of Diversity (SID). The results revealed high multidrug resistance prevalence (55%) while a smaller number of isolates displayed resistance to either one (15%) or two (25%) antibiotic classes. There was only one susceptible isolate (5%). Biofilm-forming capabilities showed negative biofilm formation (30%), weakened positive (25%), moderate positive (30%), finally strong positive was exhibited in 3 isolates (15%). ERIC-PCR demonstrated high differentiation ability between bacterial isolates in the current study compared to RAPD-PCR. Notably, significant associations were found between biofilm formation categories with ERIC-PCR clusters, and between sample sources with ERIC-PCR clusters. This highlights ERIC-PCR's potential for epidemiological investigations and infection control of P. mirabilis.
Molecular identification of some virulence genes in Klebsiella pneumoniae isolated from different clinical cases
Authors: Alnaqeeb S. T. , Gergees S. G.
Published: October 2024

The aim of this work was to acquire a better understanding of the molecular epidemiological aspects of Klebsiella pneumoniae in Iraq, which is critical for the prevention and management of K. pneumoniae infection and transmission. Two genes involved in antibiotic resistance, blaTEM and blaSHV, were detected. Results showed that 100% of the isolates exhibited both blaTEM and blaSHV, which suggests that both genes are carried on the same plasmid due to the fact that they were presented in all isolates. The presence of wzi, a gene required for capsular polysaccharide, and rmpA, a capsule synthesis accelerator, was detected in all Klebsiella isolates, indicating the importance of both genes in antibiotic-resistant K. pneumoniae and demonstrating that all Klebsiella strains under study are polysaccharide producers and thus may be strong biofilm producers. This study reveals that the clinical isolates randomly selected were highly pathogenic which is considered a threat to health providers in Iraq.
Effect of Viola tricolor flower supplementation on body and intestinal microbiota in rats fed a high-fat diet
Authors: Bilan M. V. , Lieshchova M. A. , Bohomaz A. А. , Brygadyrenko V. V.
Published: October 2024

The use of herbal medicines, due to their wide therapeutic spectrum and absence or minimal side effects, is an important area of therapy that is used in the treatment of diseases of various etiologies. Garden violet /wild pansy (Viola tricolor L.) is a medicinal plant of the violet family that is widely distributed in Ukraine. The herb of this plant (Violae herba) is used as the official raw material, which is sold in dry form as an independent remedy and as a part of herbal teas. In this study, we determined the overall effect of dry V. tricolor herb as part of a high-fat diet on body weight gain, metabolic processes in model animals, and the effect on their intestinal microbiota. For the experiment, 15 male white laboratory rats were divided into three groups and fed a high-fat diet (15% vegetable fat) supplemented with 0.5% and 2.0% dried V. tricolor herb for 30 days. Consumption of 2.0% of the herb resulted in increased weight gain compared to the control group. The dried herb V. tricolor at a dose of 0.5% in the diet of rats caused an increase in the relative weight of the brain and large intestine (caecum and colon) and a decrease in the weight of the thymus. At a dose of 2.0%, the relative weight of the thymus and caecum increased, but the relative weight of the colon decreased, and the length of the colon and rectum decreased compared to the control group. The diet supplemented with V. tricolor at a dose of 0.5% caused a decrease in globulin concentration and changes in protein ratio, and at a dose of 2.0% – an increase in total protein, albumin, albumin/globulin ratio and a decrease in globulin level. The addition of 0.5% V. tricolor dried herb resulted in an increase in high-density lipoprotein (HDL) cholesterol and a decrease in cholesterol at 2.0%. Regardless of the dose, V. tricolor contributed to a reduction in the plasma atherogenic index. Both doses of violet caused a sharp and significant increase in the De Ritis ratio and a decrease in alkaline phosphatase activity. Adding 0.5% and 2.0% violet herb to high-fat diet helps maintain the quantitative composition of the main intestinal microbiota of laboratory rats (Bifidobacterium, Lactobacillus and typical Escherichia coli). It was found that 2% of violet herb in the diet had a bacteriostatic effect on low-fermenting Escherichia coli and Klebsiella spp. and a bactericidal effect on Enterococcus spp., which can disrupt normal intestinal functions and cause diseases.
Analytical modeling and computational optimization for a 1-DOF compliant mechanism
Authors: Nguyen Hung Dinh , Le Hung Van , Dang Minh Phung , Le Hieu Giang , Dao Thanh-Phong
Published: October 2024

The first natural frequency directly affects the operational conditions of compliant mechanisms in precision engineering systems. To address this challenge, a computational method based on the surface response method is proposed to optimize the frequency of a new one degree of freedom (DOF) compliant mechanism. Initially, a 1-DOF 3D model of a compliant mechanism is built. The dynamic equation and the frequency response are formulated via equivalent stiffness and the Lagrange method. Subsequently, a series of numerical simulations are conducted to find the fundamental frequency of the mechanism. The initial dimensions of the flexible joints are determined, and the initial frequency is analyzed by using finite element analysis. Next, the flexible joints in the designed mechanism are optimized by a variant of the genetic algorithm. The optimized dimensions of the mechanism are found with the thickness of the circular joint of 1.10 mm, the thickness of the leaf joint of 1.19 mm, and the length of the leaf joint of 54.50 mm. The optimized result showed that there is a significant improvement in the frequency of the mechanism, increasing from an initial design of 53.218 Hz to an optimal design of 75.927 Hz with an improvement of 42.6%. This study provides important reference materials for future research on compliant mechanisms.
Church music degree programmes at the University of Catholic Church Music and Music Education (HfKM) Regensburg (Germany). The history of an unusual university
Authors: Hönerlage Christoph
Published: October 2024

The Regensburg University of Catholic Church Music and Music Education (HfKM), founded in 1874 as the Regensburg School of Church Music by Franz Xaver Haberl, is the world’s oldest Catholic institution for church music. With international significance from its inception, the institution was officially affiliated with the Pontificio Istituto di Musica Sacra in Rome in 1962. In 1973, it was transformed into an academy and, in 2001, the HfKM was formally established. The university offers Bachelor's and Master's programs in Church Music, Gregorian Chant, and New Sacred Music, emphasizing both artistic and pedagogical training. The curriculum prepares students not only for liturgical and pastoral responsibilities but also for broader cultural roles. Students gain expertise in areas such as Gregorian chant, choir conducting, and organ performance. HfKM maintains close ties with the church, combining artistic training with liturgical practice. This comprehensive education equips students for significant roles in both church and society, ensuring church music’s contribution to religious and cultural life.
The theological dimension of selected Polish Easter songs
Authors: Litawa Karol
Published: October 2024

The theology of Polish Easter hymns focuses on the mystery of Christ’s resurrection and is directed towards the eschatological dimension of human existence. Through the victory of the Son of God over sin, death and Satan, man has an open gate to eternal life. Easter songs are rooted in the biblical account of the Lord’s resurrection and are a form of prayer expressed both during and outside the liturgy, and should therefore bring the faithful closer to God. The oldest hymns, dating back to the 14th century, were composed throughout the centuries of the existence of the Polish nation and state, and often referred to the historical and social situation of Poles, especially during the partitions. However, their content and melody have always expressed the essence of man’s faith in the resurrection of Christ and the hope of eternal life.
Education of church musicians in Krakow in the period from the end of the Second Vatican Council to the present day
Authors: Delimat Wiesław
Published: October 2024

The training of church musicians in Cracow in the period after the Second Vatican Council became one of the important tasks of the institutional Church associated with the post-conciliar renewal of the liturgy. In the 1970s, the training of church organists here took on a systematic and organised character. The activities of the Archdiocesan Organist’s College, as well as the Church Music Section at the Liturgical Institute, were constantly evolving. Over time, their tasks were taken over by the Archdiocesan Organist School (now the Archdiocesan Music School) and the Pontifical Academy of Theology in Krakow (now the Pontifical University of John Paul II in Krakow). Since 1997, the Academy of Music in Cracow has also been educating church musicians. At present, Cracow and the Archdiocese of Cracow offer many opportunities of professional music education, which are eagerly used by organists, choir conductors, as well as people passionate about Gregorian chant, liturgical composition and the broadly understood animation of the musical life of churches. The immediate impulse for writing this article was the 25th anniversary of the Cardinal Franciszek Macharski Archdiocesan School of Music, celebrated in 2023, which is an ­important link in the series of educational institutions thanks to which the level of education of church musicians is constantly rising.
Mądrość praktyczna
Authors: Sawicki Bernard
Published: October 2024

Recenzja publikacji:
Theo Flury, Verso l’improvvisazione organistica. Basi di composizione, elementi propedeutici all’improvvisazione, esercizi ed esempi. Introduzione alla cultura organistica e alla liturgia, a cura di A. Sala, revisione di A. Piovano, Libreria Editrice Vaticana, 2024
Reverse myocardial remodeling according to cardiac magnetic resonance imaging in patients with heart failure and atrial fibrillation receiving dapagliflozin
Authors: Saipudinova K. M. , Uskach T. M. , Sharia M. A. , Ustyuzhanin D. V. , Tereshchenko S. N.
Published: October 2024

Aim. To determine the effect of dapagliflozin on cardiac remodeling parameters and left ventricular mass according to cardiac magnetic resonance imaging in patients with heart failure (HF) with reduced ejection fraction (EF) and atrial fibrillation (AF).

Material and methods. The study included 60 patients with HF and AF receiving triple therapy for heart failure for at least 3 months, which were divided into two groups. Patients in the first group (1) were prescribed dapagliflozin, while patients in the second group (2) formed the comparison group. The study analyzed the following cardiac remodeling parameters and left ventricular (LV) mass measured using cardiac magnetic resonance imaging at baseline and after 6 months.

Results. Dapagliflozin led to a significant increase in LVEF from 29±6 (27-31) to 37±9 (33-40)% (p<0,001), and a decrease in the volumetric and linear dimensions of the LV and left atrium as follows: end-diastolic dimension from 70 (64-73) to 63 (60-70) mm (p<0,001), end-systolic dimension from 55±7 (52-58) to 50±7 (47-52) mm (p<0,003), end-diastolic volume from 239±50 (220-258) to 207±43 ml/m2 (191-223) (p<0,001), end-systolic volume from 170±40 (155-185) to 140±33 ml/m2 (p<0,001), left atrium from 48±5 (46-49) to 44±6 (42-46) mm (p<0,001), and a decrease in LV mass from 156,5 (130-180) to 109 (98-145) g (p=0,001).

Conclusion. In patients with HF with reduced LVEF and AF, dapagli­flozin therapy promotes reverse myocardial remodeling processes and increases cardiac contractility.
Typical profile of a patient with atrial fibrillation in the Russian population based on medical registries. A systematic review
Authors: Stepina E. V. , Martsevich S. Yu. , Lukyanov M. M. , Navasardyan A. R. , Merkusheva L. I. , Okshina E. Yu. , Drapkina O. M.
Published: October 2024

Aim. To compare clinical and anamnestic characteristics of patients with atrial fibrillation (AF) included in three large international stu­dies assessing the efficacy and safety of therapy with direct oral anti­coagu­lants, with the profile of a typical Russian patient with AF in clinical practi­ce, established by medical registries in the Russian Federation (RF).

Material and methods. A systematic review of scientific publications was con­ducted. The search was conducted in the E-library and Google Scholar databases. Publications from 8 registries of patients with AF, con­ducted in the Russian Federation from 2012 to 2023, were found, which present the clinical and anamnestic characteristics of patients. All studies included in the analysis meet the generally accepted require­ments for medical registries. The systematic review protocol was pre­viously recorded in the PROSPERO electronic database (CRD42024512425).

Results. A Russian patient with AF is a patient with a large number of cardiovascular pathologies and a high risk of thromboembolic events. According to the analysis, Russian patient with AF has an average age of ~70 years. Most patients have a diagnosis of hypertension, heart failure, while from one third to half of patients have a diagnosis of chronic kidney disease. From 20 to 30% of patients have a history of myocardial infarction and every fifth patient has type 2 diabetes.

Conclusion. In all countries around the world, including the Russian Fe­deration, for many years, medical registries have been one of the main sources of information on the characteristics of patients with AF and the disease course. They can supplement the available data from randomized clinical trials with real-world data. Comparison of clinical and anamnestic characteristics of patients in randomized clinical trials of direct oral anticoagulants with characteristics of patients in the Russian registries shows that patients included in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K An­tagonism for Prevention of Stroke and Embolism Trial in Atrial Fib­rillation (ROCKET AF trial) were most similar to Russian patients with AF.
Analysis of the vaccination situation against Mpox in people living with HIV/AIDS: an ecological study
Authors: Tavares Núbia Vanessa da Silva , Santos Amuzza Aylla Pereira dos , Carvalho Mariana Maria Pereira Cintra Farias , Melo Kariane Omena Ramos Cavalcante de , Oliveira Hillary Gabriela dos Santos , Bernardo Thaís Honório Lins , Calheiros Selma Sabrina de Albuquerque , Santos José Augustinho Mendes
Published: October 2024

ABSTRACT Objectives: to analyze the vaccination situation against Mpox in people living with HIV/AIDS in Brazil. Methods: an ecological study on the vaccination status against Mpox in people living with HIV/AIDS (PLWHA) in Brazil. The data were collected in April 2023 through information from the Ministry of Health, using the “Microsoft app Power BI,” which is publicly accessible. Results: the data analysis revealed that in Brazil, 2,978 doses of the MVA-BN Jynneos Mpox vaccine were administered in PLWHA, resulting in a vaccination coverage of 18.3%, with the southern and southeastern regions showing the lowest and highest vaccination coverage, respectively. Gender-based evaluation showed a higher proportion of vaccinated males. Conclusions: we identified low vaccination coverage in all regions of Brazil, highlighting the need for intensified vaccination activities, especially for PLWHA.
CRITICAL VIEW OF SAFETY: A PROSPECTIVE SURGICAL AND PHOTOGRAPHIC ANALYSIS IN LAPAROSCOPIC CHOLECYSTECTOMY – DOES IT HELP TO PREVENT IATROGENIC LESIONS?
Authors: BLITZKOW Ana Carolina Buffara , FREITAS Alexandre Coutinho Teixeira de , COELHO Júlio Cezar Uili , CAMPOS Antonio Carlos Ligocki , COSTA Marco Aurelio Raeder da , BUFFARA-JUNIOR Victor Assad , MATIAS Jorge Eduardo Fouto
Published: October 2024

ABSTRACT BACKGROUND: The incidence of biliary duct injuries remains higher in laparoscopic cholecystectomy (LC) in comparison to open surgery. The Critical View of Safety (CVS) was introduced by Strasberg as a strategy for reducing this catastrophic complication. AIM: The aim of this study was to evaluate how often an adequate CVS is achieved during LC, the determining factors for its success, and the associated surgical outcomes. METHODS: This is a prospective study. CVS photographs of all patients who underwent LC by the same surgeon between 2020 and 2023 were taken. Success in achieving CVS was analyzed by the surgeon herself and posteriorly by hepatobiliary specialists. Patients were classified into two groups: CVS achieved and CVS not achieved. Finally, multivariable logistic regression was used to examine the association between preoperatory factors and surgical complications. RESULTS: Three hundred and nine consecutive patients were submitted to LC. There were 73.5% elective CL and 26.5% acute cholecystitis. The age ranged from 14 to 87 years, and 76.8% were female. The median body mass index was 26.7. Previous abdominal surgeries were present in 64%, and 26% were obese. The CVS was achieved in 79.9% of the patients, and there were no surgical complications in this group. The factors associated with nonachievement were acute cholecystitis (p=0.007), male sex (p=0.014), and previous surgeries (p=0.021). Three patients needed a subtotal cholecystectomy due to severe inflammation. There was no statistical correlation between the identification of CVS and surgical complications. CONCLUSIONS: The CVS is achieved in most patients. Acute cholecystitis, male sex, and previous abdominal operations are associated with difficulties in obtaining CVS.
Three-dimensional printed bioresorbable scaffold for maxillofacial bone reconstruction: A Scoping Review
Authors: Malzoni Carolina Mendonça de Almeida , Oliveira Jovânia Alves , Soares Lélio Fernando Fereira , Chimirri Marcella Cunha , Almeida Daniel Augusto de Faria , Pigossi Suzane Cristina , Marcantonio Junior Elcio
Published: October 2024

Abstract This scoping review aimed to provide an overview of current advancements in virtual planning and custom-made 3D-printed bioresorbable scaffolds, and to evaluate their clinical outcomes in maxillofacial reconstructive surgeries. Electronic searches of PubMed, EMBASE, Web of Science, Scopus, and Cochrane Library databases were conducted for publications up to June 2024. Included in the review were reports evaluating patients who underwent maxillofacial bone defect reconstruction using virtual planning and custom-made 3D-printed bioresorbable scaffolds. Data on postoperative complications, new bone formation, scaffold resorption, dental implant success/survival, and patient satisfaction were collected. The electronic search found 5799 results (3438 unique citations). A total of 54 studies were evaluated for full-text reading, of which 41 were excluded based on the inclusion criteria. Thirteen studies (6 case reports, 5 case series, one prospective clinical study and one randomized clinical trial) were included. These studies assessed the effectiveness of 3D-printed scaffolds in reconstructing maxillofacial defects, bone augmentation for dental implant placement, and regeneration of periosseous defects. Most of the 3D-printed scaffolds were biocompatible and did not cause local or systemic adverse events. However, some postoperative complications were reported, including graft exposure, wound dehiscence, and local infection. Overall, the 3D-printed scaffolds demonstrated favorable dimensional compatibility with deformities, provided durable support, promoted bone formation, achieved adequate bone union with host bone tissues, and supported dental implant placement without additional guided bone regeneration. In conclusion, custom-made 3D-printed bioresorbable scaffolds, guided by virtual planning, present a promising option for maxillofacial reconstruction due to their accuracy, osteoconductivity, and biocompatible properties.