bluuebunny/crossref_metadata_2025 huggingface dataset:
Gibberellic acid signaling promotes resistance to saline–alkaline stress by increasing the uptake of ammonium in rice
Authors: Li Zhuo , Chen Huan , Guan Qingjie , Li Lixin , Xuan Yuanhu
Published: April 2023

Gibberellic acid (GA) plays important roles in diverse biological processes in plants. However, its function in the resistance of rice (Oryza sativa) to saline-alkaline (SAK) stress is unclear. In this study, we found that SAK stimuli changed the levels of expression of the GA signaling genes. Genetic analyses using the mutants of key GA signaling regulators Slender rice 1 (SLR1) and Dwarf 1(D1) demonstrated that SLR1 negatively regulated the resistance of rice to SAK stress, while D1 positively regulated it, suggesting the GA signaling positively regulates the resistance of rice to SAK. A previous study showed that SLR1 interacts with Phytochrome interacting factor-like 14 (PIL14) to regulate the resistance of rice to salt stress. However, PIL14 overexpressor (OX) plants exhibited a similar response to SAK as the wild-type (WT) controls. Further analyses revealed that SLR1 interacted with and inhibited the activation of transcription of IDD10 and bZIP23. Furthermore, IDD10 interacted with bZIP23 to activate Ammonium transporter 1;2 (AMT1;2), and slr1, IDD10 OX and bZIP23 OX accumulated more ammonium (NH4+) than the WT plants. In addition, the bzip23 T-DNA mutant was more sensitive to SAK, while bZIP23 OX was less sensitive compared with the WT. This suggested that bZIP23 is similar to IDD10, which positively regulates the resistance of rice to SAK. Taken together, this data proved that GA signaling promotes the resistance of rice to SAK by modulating the uptake of NH4+ in rice mediated by SLR1-IDD10-bZIP23.
Assessment of Women's Awareness of Reproductive Health Concepts in Iraqi Community
Authors: Zubair Omaima Abdulrazzaq
Published: April 2023

Background
Reproductive and sexual health knowledge is a major health indicator in communities. Underestimation of awareness of its determinants will affect the welfare of people and retreat community progress. The present study aims to assess women’s awareness of reproductive health in the Iraqi community.
Methods
To collect the information from the participants, the researcher has adopted a cross-sectional study design with questionnaire form has distributed among all Iraqi governorates via Google form through social media and direct interviews. A convenient sample of 3416 women was included in the study.
Results
Only a third of the participants have adequate awareness regarding premarital care, child marriage, and breastfeeding. Sexually transmitted disease and contraceptive methods awareness were represented by only 20%, and 10% of the participants, respectively. Relativity of marriage was prevalent in 26% of married participants. Vaccination and vitamin supplementation, and a healthy diet had better representation of adequate knowledge 44%,41%, and 55%, respectively; in opposite to sports knowledge who represents just (8%) of them. About half of the participants have adequate knowledge concerning the effect of stress on health but little knowledge about healthy sleeping patterns (27%). health facilities usage awareness was 5% with private facilities visits occupying the most predominant visit site.
Conclusion
The study revealed a minimal level of awareness about reproductive health among participants women and girls in the Iraqi. An education programs should be directed to all Iraqi strata to raise their level of awareness about this subject
Perception of Fluency Therapy of Stutterers by their Parents in Rural Area-comparative Study Based on Group and Severity
Authors: Sukumar Meenakshi , Bar Mital
Published: April 2023

Stuttering is a speech disorders which intermittent interruptions of fluent articulation. Stuttering is an impairment of “Speech that is characterized by frequent repetition or prolongation of sounds or syllables or words that disrupt the rhythmic flow of speech“. This study aims to know the perception of parents toward speech/fluency therapy for PWS in rural areas in Gujarat. A closed-ended questionnaire (yes/no) consisting of 20 questions which were develop helps in gathering information in aspects of the perception of client problem, fluency therapy, and availability of therapist, the duration of therapy session, and their comfortability toward therapist, technique effectiveness, and the improvement in the therapy and implementation in daily life. Thirty parents/caregivers of stuttering clients in that the subjects are divided into two groups, that is, Group-A age range of (10–20 years) and Group-B age range of (20–30 years). These two groups are subdivided into three categories with five subjects in each category, that is, mild, moderate, and sever stuttering. The study was conducted to see the level of perception of stuttering and its therapy. Hence, the results suggested that comparison between Group-A and Group-B. In Group-A, responses were better for (mild, moderate, and severe) as compared to the Group-B (mild, moderate, and severe) responses, because as the person grows older the parents involvement that will be less due to that reason younger subjects responses were better as compared to the older subject responses.
Characterization of Impurities in Reverse Transcriptase Inhibitors by Profiling Techniques
Authors: Shelke Ashwini V. , Lokhande Tushar N. , Pardeshi Vaishali , Daware Kavita , Jadhav Shweta , Jadhav Anil
Published: April 2023

There has been ever growing activity in impurities existing in pharmaceutical products as well as bulk drugs. According to a range of regulatory authorities, no longer solely purity profiles, however additionally impurity profiles, are now required. The technique facts for an individual impurity’s organic safety are recognized as impurity profiling. The many developments in analytical viewpoints of impurity profiling of anti-retroviral (ARV) medicines and products used to deal with human immunodeficiency virus (HIV) infections are described in this review. ARVs work using inhibiting unique ranges of the viral contamination cycle to produce therapeutic benefits. Thus, drug classes are stratified as nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NTRTIs), non-NRTIs (NNRTIs), integrase strand transfer inhibitors, CCR5 antagonists, viral fusion inhibitors, and protease inhibitors (PIs). In this overview predominant focal point given on class that is reverse transcriptase inhibitors (RTIs). The wide variety of papers dealing with ARV drug impurity profiling is developing at an alarming pace. The cutting-edge overview article, which is based primarily on publications posted in the closing 15 years, tries to provide vast data concerning RTIs drug impurity profiling. RTIs which are labeled into two sub-categories, that is, NRTIs and NNRTIs. NRTIs pressure the HIV virus to use erroneous variations of building block, so contaminated cells cannot make more HIV and NNRTIs these are additionally referred to as “non-nukes.” NNRTIs bind to a precise protein so the HIV virus cannot make copies of itself. The investigatory overview might also furnish the complete important points to the researchers who are working in the region of impurity profiling of RTIs. To the most tremendous of our information, no overview until date noted to center of attention on impurity profiling of RTIs.
Extraction, Purification, and Characterization of Lepidium sativum Mucilage for Product Development
Authors: Archana Archana , Singh Vijay
Published: April 2023

Since ancient times, various human civilization are using herbal medications for different ailments. Herbal medications are being extensively researched and promoted in various health care programs in India. Scientist from across the globe is attracted toward the potential medicinal values of different herbs and is working to blend herbal medications with novel formulation technologies to overcome the difficulty associated in developing formulations based on herbal medications. Cress or garden cress (Lepidium sativum) has been widely reported for its numerous pharmacological activities. The cress seeds possess numbers of nutraceutical values from rubefacient, galactogogue, and laxative to diuretic properties. In the present study, mucilage is extracted from the seeds of L. sativum by different methods, in which the treatment of dried of mucilage powder with ethanol yields highest amount of mucilage. Further, purification was done exploiting the method of Munir et al. with slight modification. Chemical characterization shows presence of carbohydrate, mucilage, and polysaccharide. Proximate analysis also confirms the presence of crude fats (2.37%), proteins (3.07%), fibers (4.71%), and carbohydrates (77.72%) and total calculated energy was 287.62 kcal/gm. Physiochemical analysis shows 4.8% loss of moisture on drying; particle size of grinded mucilage 500–1000 μm; 7.6 pH of 0.5% solution of L. sativum mucilage; 227–229°C charring temperature; good swelling and flow properties; and compressibility index 0.26 and 26.0% compressibility. Fourier-transform infrared analysis of L. sativum mucilage shows presence of O-H, C-H and C=O functional group. The extraction and characterization of L. sativum mucilage could be further used for possible product development.
Exploratory Data Analysis and Decision Tree Modeling for Autism Spectrum Disorder: Machine Learning Approach
Authors: Kamath R. S. , Jamsandekar S. S. , Badadare V. L. , Kamat R. K.
Published: April 2023

As the early diagnosis of autism spectrum disorder (ASD) is critical the high accuracy machine learning can be applied to achieve technology based diagnosis. In this context, the present study demonstrates machine learning approach for ASD diagnosis using decision tree (DT) modeling. The dataset employed in the present study comprises two classes of ASD adults with a sample size of 704 instances. The DT model entails a recursive partitioning approach implemented in the “rpart” package of R. The optimum model is derived by tuning parameters such as Min split, Min bucket, Max depth, and complexity. The performance of the model is evaluated in terms of the mean square error estimate of the error rate.
Impact of COVID-19 on the Dietary Pattern of Indian Population: A Cross-sectional Study
Authors: Mishra Abhisek
Published: April 2023

Background: COVID-19 pandemic triggered fear, anxiety, and worries among people making it a phobia, named as Coronaphobia. This, in turn, changed the dietary pattern of people. Objective: The present study was carried out to investigate, whether there was a change in the dietary pattern of during pandemic. Methodology: An online survey was conducted using Google Form to assess the change in the dietary pattern of Indian population (n = 130) during the pandemic. Moreover, the present study examines the impact of socioeconomic profile of respondents to the extent of change in dietary pattern using a multiple regression equation. Results: The study finds that 76% of the participants, of which 69% were male changed their dietary pattern. Further, addition of immunity boosters along with the normal meal was prominent as the changed dietary pattern among a majority of respondents. Moreover, a majority of participants stopped consuming junk food to strengthen their immunities. In addition, the study found a significant positive effect of age (P < 0.0001) on the extent of change in dietary pattern among survey participants. Conclusion: The study concludes with the recommendation that people should consume immunity boosters and also be engaged with some physical activities to strengthen their immunities.
Studies on Several Medicinal Benefits of Plant Juniperus communis
Authors: Kapadnis Mrunal Sanjiv , Pawar Saylee , Dhikale Rupali , Jadhav Anil
Published: April 2023

Juniperus communis Lin is a fragrant evergreen plant of family Pinaceae; Cupressaceae. The aromatic shrub has great potential in treatment of human and animal diseases. The plant is great source of invert sugars, wax, gums, resins, flavonoids leucoanthocyanins, organic acids, aromatic oils, terpenic acids, alkaloids, tannins, lignins, catechin, etc. Berries of juniper or plant extract used as emmenogogue, sudorific, carminative, diuretic, urinary antiseptic, digestive, and anti-inflammatory. The experiments have demonstrated that the plant’s extract as well as essential oils from plant have antifungal, antiviral, antioxidant, and antibacterial activities. Recent studies uncovered the hypolipidemic and cytotoxic activities from Juniperus berries in experimental study. Recent study also shown the insect repellant and insecticidal activity. Thus, the plant or shrub is treasure of medicinal properties, of which some are discovered and some are undiscovered. There is need to study the plant for new activities that can aid in treating many chronic diseases.
Environmental Impacts of COVID-19 Pharmaceuticals and Disinfectants.
Authors: Srivastava Bhawna , Reddy P. B.
Published: April 2023

With the outbreak of COVID-19 pandemic (SARS-COV-2), the use of several aging and irrelevant pharmaceuticals has increased strangely. Consequently, huge amounts of disinfectants and antibiotics were used prevent the spreading of COVID-19 and residual drugs are also constantly excreted in freshwater, raising concerns about potential ecotoxicological effects on aquatic organisms. The purpose of this study was to examine the prevalence of these disinfectants and pharmaceuticals in aquatic environment and their potential ecotoxicological effects and antimicrobial resistance (AMR)-promoting effects. The literature information was sourced from PubMed, Science Direct, Embase, MEDLINE, and China National Knowledge Infrastructure databases using Google Scholars, Academia, and Research gate as search engines. Results revealed that the long-term exposure to pharmaceuticals and disinfectants and its by-products may pose detrimental effects on public health, reproductive impairments, obstructive pulmonary diseases, cancers, skin damage, and damage of central nervous system. Some researchers found significant fluctuations in the community structure of planktonic species in exposed waters. Results also revealed that excess use or misuse antibiotic misuse can accelerated the development of AMR. The present assessment fills the knowledge gap on the prevalence and effects of COVID-19-related pharmaceuticals in on the aquatic environment and wildlife. The outcome our study recommends an urgent need for an ecotoxicological assessment and monitoring the flow of COVID-19-related pharmaceuticals in the aquatic environment. We also advocate for an effective waste water management and to improve the removal efficiencies of drug residues in wastewater.
Detection of Carcinogenic Dye Sudan I and Rhodamine B Using Indigenous Raman Spectrometer
Authors: Upadhyay Pankaj , Bhaskar Pobbati , Datla Ramesh
Published: April 2023

Sudan I and Rhodamine B are carcinogenic declared by European Union and California, respectively. Duo finds their uses in food and beverage products. Daily consumption can cause skin allergy and worsen to cancer. Due to its fluorescent nature it becomes erroneous to detect using Raman Spectrometer but with use of NIR diode laser it gives molecular fingerprint of dyes with associated samples. This paper presents to make an indigenous Raman Spectrometer to detect Sudan I and Rhodamine B like dyes. Raman Spectrum is taken even in water sample also through packaging.
Development of Fog-based Dynamic Load Balancing Framework for Healthcare using Fog Computing
Authors: Bhavsar Sejal , Modi Kirit
Published: April 2023

Fog computing has become one of the leading technologies by conquering the many significant challenges in IoT, Big Data, and Cloud. Computing models are inclining toward Fog than Cloud due to faster processing. The numerous idle devices near the users help overcome the issue of latency found in the Cloud. Resource management through load balancing plays an essential role in efficient data processing. Based on the current pandemic situation, Emergency patient’s vital sign monitoring system for COVID and other variants is implemented with support of dynamic resource load balancing environment. Apart from this, previously, we have faced many such diseases such as plague and flu which were pandemic and have become normal diseases now. Apart from them, there are many critical conditions and diseases such as hypertension, kidney failure, heart attack, cancer, lung, and liver disease that need continuous monitoring. It is not feasible to treat all patients at the hospital as the count is increasing very speedily. There is a need for infrastructure to handle resource issues without any delay in the treatment of patients using the fog computing. The proposed approach DynaReLoad would provide prompt health services and prevent early deaths due to critical conditions. An immediate alert to the doctors will be generated when detecting any abnormality. The effectiveness of DynaReLoad has been analyzed with other load balancing algorithms to achieve a low latency with minimum MakeSpan, better scheduling time, and response time, maximizing load balancing level and resource utilization using iFogSim.
Quality of Life and Self-care Activities Among Type 2 Diabetes Mellitus Patients on Insulin
Authors: Srivastava Tanya , Jain Sonal Gupta , Sabharwal Vandana
Published: April 2023

Context: Self-care activities play a crucial role in the management of diabetes. It can also improve quality of life in patients. Aims: The present study was carried out to understand the QoL and self-care activities among T2DM patients on insulin and find out the association between quality of life and self-care activities. Settings and Design: This study was conducted on 105 subjects (55 females and 45 males) between the ages of 40 and 60 years with more than 1 year of T2DM attending OPD in the endocrinology department of private hospitals in North-east and East Delhi. Materials and Methods: A general questionnaire along with validated self-care (SDSCA) and quality of life (QOLID) questionnaires were used to collect data. Statistical Analysis: Data analysis was done using SPSS version 21.0. For the categorical variable, frequencies and percentages were calculated and for the continuous variables mean and standard deviations were calculated. Results: Mean age of subjects being 51.3 ± 6.2 years and 55% of them were females. It was observed that diet (P = 0.016), exercise (P = 0.001), blood sugar testing (P = 0.017), and foot care (P = 0.018) were strong predictors of self-care that were affecting the QoL. Mean scores of various domains between males and females revealed better QoL in males than females in domains of physical health (3.65 ± 0.94), physical endurance (4.11 ± 0.67), general health (3.19 ± 0.71), treatment satisfaction (3.55 ± 0.44), and overall QoL (3.50 ± 0.39). Conclusions: The present study showed that self-care activities and QoL among T2DM patients were poor. Results showed that improving nutritional status of patients can be effective on their QoL improvement.
Pharmacognostic, Phytochemical Investigations, and In Vitro Anti-arthritic Activity of Adiantum venustum D. Don
Authors: Somani Vaishali , Jain Ashish , Singhai Akhlesh Kumar
Published: April 2023

The present investigation deals with pharmacognostical, physicochemical, phytochemical analysis, and in vitro anti-arthritic activity of ethanolic extracts of Adiantum venustum D. Don. The macroscopic and microscopic characters, physical constant values, extractive values, ash values, color analysis, and fluorescence analysis were performed. The stems were 13–14 cm in size while leaves were 3–5 mm. Stems were straight with nodes while leaves were triangular and fan shaped. Transverse section of aerial parts of A. venustum showed epidermis consists of closely packed cells with single layer. No intercellular space was found. Endodermis is indistinct. On microscopic examination, the powder showed wavy epidermis, parenchyma cells, Phloem, fiber, trichome, brownish matter, and crystals. Physical constants performed were loss on drying, ash content, acid insoluble ash, and water soluble ash. Extractive values in chloroform and alcohol were determined. Fluorescence studies of the powder were carried in UV, UVB, and day light with various solvents. Phytochemical screening of successive extracts showed positive reactions for steroids, flavonoids, carbohydrates, phenols, and tannins. In vitro anti-arthritic activity was performed by the inhibition of protein denaturation method. The ethanolic extracts of aerial parts exhibited remarkable anti-arthritic action. The protein denaturation was also found to be maximum at 75.293 ± 0.735 and 79.956 ± 0.9 % at a dose of 500 μg/mL by protein denaturation egg albumin and bovine serum albumin method, respectively.
Impact of COVID-19 and Lockdown on Health and Livelihoods of Transgender Individuals in Hyderabad, Telangana
Authors: Grace Chinthapally Stella , Shamanna B R
Published: April 2023

To combat the coronavirus disease which claimed lot of lives globally, India went into a complete lockdown starting March 24, 2020. This study examines the impact of COVID-19 and lockdown on one of the vulnerable groups of populations, that is, transgender people’s livelihoods, health-seeking behavior along with their perceived health-care barriers, and accessibility to health-care services. A cross-sectional descriptive study with mixed methods approach for qualitative data was done in Hyderabad city. Eighty transgender participants identified through snowball sampling method were subjected to structured interviews and 30 among them were chosen randomly and were also subjected to in-depth semi-structured interviews. Data were analyzed using MS Excel and thematic analysis. The COVID-19 lockdown has affected target group’s livelihoods and their health-seeking behavior. The denial of treatment by the doctors and unavailability of health services are hindering their accessibility to health care. Violence/harassment, discrimination, discourtesy, maltreatment, and verbal and physical abuse are major barriers for health-care utilization by transgender individuals. An inclusive policy needs to be put in place for vulnerable groups like transgenders.
Comparative Study on Sports Specific Personality among Male Physical Education Students of Uttar Pradesh
Authors: Yadav Vivit Kumar , Pant Mukul
Published: April 2023

The present study was intended to compare the various sports specific personality (sociability, dominance, extroversion, conventionality, self-concept, mental toughness, and emotional stability) of physical education students of different universities (Agra University, Lucknow University, and Mahatma Gandhi Kashi Vidyapith University, Varanasi) of Uttar Pradesh using sports personality specific test developed by Dr. Agya Jit Singh and H.S. Cheema (2010). Descriptive research design was used in this study. For the purpose of the present study, a total of 90 physical education students were selected through random sampling. The collected data were analyzed using ANOVA. Level of significant was fixed at 0.05. The results of the study indicates that there was a significant difference on extroversion and self-concept between different university’s physical education students, however, no significant difference was found on sociability, dominance, conventionality, mental toughness, and emotional-stability.
The Effect of 8 Weeks of Yogic Practice on Type-II Diabetes Mellitus and Hemoglobin among 45–55 Age Groups
Authors: Bisht Sujay , Devi Phurailatpam Laxmikumari
Published: April 2023

The purpose of the study was to access the effect of 8 weeks of yogic practice on Type-II diabetes mellitus and hemoglobin among 45–55 age groups. The present study is undertaken among 10 urban peoples, for example, five experimental groups and five control groups. They were selected randomly from rural area of Assam who recently use to practice yoga asanas regularly during the morning time for 1.30 h. A randomized single-group design was adopted in this study. The volunteers were made aware of testing and training procedure. For the collection of the data, blood glucose was measured using (Accu-Chek active blood glucose meter) and hemoglobin level was measured using (StatStrip hemoglobin and hematocrit meter system). To evaluate the hypothesis of the study, descriptive statistics such as mean, SD, and compare mean such as paired “t”-test were applied and were tested at 0.05 level of significant. The statistical findings revealed that there was a significant difference in blood glucose and hemoglobin of the subjects. The blood glucose level of the experimental group P value and t value was 0.001 and 2.7764 and the control group P value and t value was 0.969. Hemoglobin level of the experimental group P value and t value was 0.002 and 2.7764 and the control group P value and t value was 0.883, respectively. On the basis of the statistical result, it was concluded that there was a significant effect of 8 weeks of training on blood glucose and hemoglobin among the age group of 45–55 years.
Formulation Development and Release Profile of Levomilnacipran Extended Release Capsules using Principles of Quality by Design
Authors: Singh Rajnish Kumar , Choudhary Naveen Kumar , Kharia Ankit Anand
Published: April 2023

The study’s goal was to use Quality By Design (QbD) principles to design an Extended Release dosage form of levomilnacipran and evaluate its in vitro release profile. Doses of levomilnacipran extended release capsules (LERC) ranging from 20 mg to 120 mg. QbD was employed in this work to design LERC capsule formulation and production, which ensures LERC safety and efficacy. To create the LERC, wurster coating was applied to non-pariel seeds, which were then filled with capsules. To provide prolonged absorption, a polymer derived from ethylcellulose was chosen. Extensive release capsules are made up of four main components: (1) Drug layering, (2) extended release coating, (3) lubricant application, and finally (4) capsule filling. Results revealed that there was no significant difference in release profile LERC in different doses; however, the highest release of drug was seen at 120 mg, that is, 93%. The present formulation may be used as an effective treatment therapy against major depressive disorder.
Journal of Radiation hygiene – instructions for authors
Authors: Editorial Article
Published: April 2023

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A Review of Literature Based Online Fraud in India
Authors: Tripathi Smita
Published: April 2023

The purpose of the study is how the different researcher fraud can be predicted in the online transaction of data. Data analysis is an important part of fraud detection because data transformation into valuable information can result in competitive business advantages. The implementation of fraud prediction in any type of transaction on big data is one of the most important approaches applied by banks to using this approach, they shield their transaction, which is the Flow in the network. Fraud is an elementary problem with every financial institution in the word. Fraud has been a million-dollar business that is fastly growing at the international level.
A Study on Exploration of Factors for Consumer's Behaviour Economics in Banking and Insurance Industry
Authors: Singhai Manisha , Shrotriya Akshay
Published: April 2023

Economic considerations influence consumers' behavior since they expect to receive some return on their investment and are eager to accumulate more interest over time. Therefore, the banking and insurance industries offer a large platform for those customers who have faith in these sectors and are prepared to invest by buying policies or other alternatives for the various utilities, consumers eager to invest, and consumers based on their needs, offer by industry and decision. By purchasing life insurance, people can safeguard their families financial future in the event of their own untimely passing. Life insurance plays a crucial role in the financial security of a significant portion of society because of the lack of access to formal financial markets and the lack of knowledge and financial literacy. Particularly crucial are the rural and less affluent segments of society. In this study, 415 respondents from Madhya Pradesh, especially Indore, Bhopal, Gwalior and Ujjain, were chosen through random technique and the study area is the banking and Insurance Industry where they have to take decisions carefully for their future planning.
The Grey Shade of Management and Management Education
Authors: Kumar Alok , Singh Sudeep K. , Pathak Pramod
Published: April 2023

Since the Government is talking about revamping the higher education structure in our country under the generic basket of New Education Policy (NEP), Management Education seems to provide the basic structural element towards the same. Moreover, the focus on the skill element in the ‘being implemented’ policy further accentuates the need and role of management education across various disciplines irrespective of whether already existing or thought off in the years to come depending upon the shape and character of the Indian Economy supposed to lead the world in a way where predictions are a bit difficult. The current situation is like ‘Amrit Manthan’ and this will take some time before things settle down to pave way for a clearer path to such an issue! But then, as it is well known across academic and industry peers, no other education is complete without management education. This is so because two important ingredients: resources and the environment, have no alternatives. They will remain forever and will keep playing a vital role towards maintaining what we intend to call ‘Grey’ shade of Management Education. This article covers some very basic issues that may help us understand the colour ‘Grey’, synonymous with the extensive coverage and maturity that we all envisage in our country of multiple colours. Moreover, it looks to some thoughts on the ‘Management’ field itself being grey!
Challenges faced by Self-help Groups in taking up Entrepreneurship in Uttar Pradesh
Authors: Usmani Asad K. , Anees Mohammad
Published: April 2023

Entrepreneurship has always attracted the attention and interest of several individuals like economists, politicians, social reformers, businessmen etc. Entrepreneurs are considered a significant component of our society that has played a critical role in changing our country’s business and employment scenario. By adopting the process of entrepreneurship, entrepreneurs have contributed to the nation’s GDP by adding new products or services and making them available for consumption. In doing so they have to face several challenges that are related to wide range of issues. A successful entrepreneurial venture requires funds, resources, manpower, technical know-how, awareness, and knowledge about policies and processes. Earlier while thinking about entrepreneurs, only rich affluent businessmen have quick and easy access to funds and resources would come to mind, however microfinance initiatives by self-help group have taken entrepreneurship to rural areas, villages and small town. This paper intends to study and bring to various light challenges that SHGs face while taking up entrepreneurship in the state of Uttar Pradesh.
EFEITOS DAS MÚLTIPLAS ESTRUTURAS E DA ANARMONICIDADE TORCIONAL PARA AS REAÇÕES DE ABSTRAÇÃO DE HIDROGÊNIO NO BUTANOATO DE METILA PELO RADICAL H
Authors: Nascimento Joel , Alves Tiago
Published: April 2023

EFFECTS OF MULTIPLE STRUCTURES AND TORSIONAL ANHARMONICITY FOR THE HYDROGEN ABSTRACTION REACTIONS OF THE THMETHYL BUTANOATE BY H RADICAL. Thermal rate constants for the hydrogen abstraction reactions of the methyl butanoate (MB) by H radical were estimated by applying the multistructural canonical variational theory with small-curvature tunneling (CVT/SCT). The conformational search was performed at MPWB1K/6-31+G(d,p) level of theory and 68 distinguishable conformers for MB and transition state located. The multistructural and torsional anharmonicity effects were corrected through the rovibrational partition functions calculated with the multistructural method based on a coupled torsional potential, MS-T(C). The MS-CVT/SCT thermal rate constants are shown in good concordance with previous combustion models. After fitting the rate constants in a four-parameters equation, the activation energy showed a temperature dependence. The product branching ratios indicate a preference for (Rα) until 500 K. Above this temperature, the contribution of other reactions becomes relevant, especially for (Rβ).
Prioritizing Critical Success Factors of Requirements Engineering using Analytical Hierarchy Process
Authors: Eitiveni Imairi , Hutapea Hardyn Alexander
Published: April 2023

Requirements engineering is not as straightforward as asking stakeholders what they want the information systems to do. In most cases, their vision tends to be limited by the status quo. Eliciting a complete set of requirements that fulfil every gap and withstand scrutiny during validation is challenging. Hence, it is important to consider various factors influencing the success of requirements engineering. This paper identifies and prioritizes multiple critical success factors of requirements engineering using the Analytical Hierarchy Process. The initial model was developed from literature review and validated using evidence from an empirical study. Quantitative data was collected through a questionnaire and then analyzed to rank the success criteria and critical success factors. The results show that the user satisfaction is the most important success criterion, while the clear definition of project scopes and goals is the most critical factor for the success of requirements engineering.
Study of foramen openings and their concurrence with root apexes
Authors: Sandra Maria Alves SAYÃO MAIA  , Ana Paula Peres COSTA  , Ana Tereza de Albuquerque LEMOS  , Valeska Rodrigues Jacob TORRÃO  , Ana Virginia Silva VILELA
Published: April 2023

The present study is aimed at evaluating the anatomic concurrencebetween foramen openings and root apexes of 247 upper and lowerpermanent human molar canals, the distance between these structures,the instrument that best fits into the root canal, as well as the directionof foramen deviation. Sixty-four of the canals were partiallyimpenetrable and were discarded. The findings showed that 39.9% ofthe root canals studied had their apical foramen concurrent with theirroot apexes and 60.1% did not. Clinicians must be made aware of thisimportant anatomical detail, which could be indispensable forsuccessful endodontic treatment.
Reparação microcirúrgica de nervo facial de ratos Wistar por meio de sutura – Parte 1
Authors: João Armando BRANCHER  , Maria Fernanda TORRES
Published: April 2023

O nervo facial direito de 20 ratos da raça Wistar foi seccionado eimediatamente tratado com três pontos de sutura epineurais. A análisedos resultados foi baseada no aspecto histopatológico da áreaanastomótica. Percebe-se que a presença do material de sutura foiresponsável pelo pobre direcionamento das fibras nervosas e formaçãode neuroma na área de anastomose em virtude da colisão das fibrasnervosas em regeneração com a reação granulomatosa ao fio de sutura.Alterações como degeneração walleriana e proliferação de tecido fibrosoforam observadas.
Editorial
Authors: Adriane Cristina Kasprowicz
Published: April 2023

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Avaliação da microbiota salivar de pacientes pediátricos com e sem diabetes melito do tipo 1
Authors: Suellen ZAITTER  , Camila FERENCZ  , Paulo Henrique TOMAZINHO
Published: April 2023

Diabetes melito é uma doença metabólica que pode ocorrer na infânciae na adolescência como resultado da deficiência de insulina, deresistência periférica ou ambos. Sua inter-relação com a odontologiase dá por intermédio de vários sinais e sintomas na cavidade bucal,além de aumentar o risco de doenças periodontais e cárie dental. Oobjetivo deste estudo foi avaliar microbiologicamente a saliva de criançascom e sem diabetes. Amostras salivares foram coletadas e plaqueadasem kits de laminocultivo específicos para Lactobacillus e S. mutans,incubadas e contadas conforme instruções do fabricante (Laborclin®).Na contagem de Lactobacillus observaram-se médias de 4,5 e 3,5 nolog10 (p = 0,01), em crianças com e sem diabetes, respectivamente.Na contagem de S. mutans foram obtidas médias de 4,1 e 3,7 no log10(p = 0,11) em crianças com e sem diabetes, respectivamente. Pode-seconcluir que crianças com diabetes abrigam uma contagem maior deLactobacillus salivar do que crianças sem a doença.
Editorial
Authors: Adriane Cristina Kasprowicz
Published: April 2023

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Editorial
Authors: Adriane Cristina Kasprowicz
Published: April 2023

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Análise radiográfica da trajetória do quarto canal no primeiro molar superior
Authors: Patricia Oyarzabal de Melo FERREIRA  , Erica Lopes FERREIRA  , Luiz Fernando FARINIUK  , Flares BARATTO FILHO  , Gisele Aihara HARAGUSHIKU  , Sandra Maria Alves SAYÃO
Published: April 2023

O objetivo deste trabalho foi avaliar radiograficamente a trajetóriado canal mesiopalatino em primeiros molares superiores, visandoverificar a importância da análise radiográfica no tratamento dessegrupo de dentes, tendo em vista a grande incidência de dois canaisna raiz mesiovestibular. Foram utilizados neste estudo 65 primeirosmolares superiores extraídos, doados por alunos da PUC/PR. Osdentes foram radiografados com películas radiográficas periapicais,com 20 graus de angulação na incidência disto-excêntrica e composicionamento de limas tipo K n.° 10 nos canais. A análise buscoudistribuir a amostra de acordo com a classificação do sistema decanais radiculares proposta por Weine [7]. O resultado obtido foi:47,7% (31) do tipo I; 21,5% (14) do tipo II; 12,3% (8) do tipo III;18,5% (12) calcificados. Pode-se concluir que a análise cuidadosada raiz mesiovestibular é importante para que se possa assegurarum bom prognóstico ao tratamento.
Editorial
Authors: Adriane Cristina Kasprowicz
Published: April 2023

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Oclusão e periodontia: uma análise crítica da literatura
Authors: Flávia Aparecida Chaves FURLANETO  , Luiz Gustavo Nascimento de MELO  , Maria José Hitomi NAGATA  , Alvaro Francisco BOSCO  , Tatiana Miranda DELIBERADOR  , Michel Reis MESSORA  , Alicio Rosalino GARCIA
Published: April 2023

Introdução: O trauma oclusal é definido como a injúria que resultaem mudanças teciduais dentro do aparato de inserção dos dentes comoresultado de forças oclusais. Desde 1901, quando Karolyi relatou sobrea possível existência de uma ligação entre desarmonias oclusais ealterações periodontais, a literatura científica tem buscado indíciosque corroborem ou não essa inter-relação. Objetivo e revisão deliteratura: Os autores revisam, neste trabalho, os estudos que analisam a oclusão traumática como suposta agravante da doença periodontal,assim como as possíveis vantagens quando da associação da terapiaoclusal à periodontal. Embora ainda existam muitas dúvidas a seremesclarecidas para o completo entendimento dos efeitos das forçasoclusais sobre o periodonto, uma oclusão funcional é fundamentalpara o equilíbrio dos diversos componentes do sistemaestomatognático, no qual as estruturas periodontais estão incluídas.Conclusão: O ajuste oclusal, quando indicado, deve ser realizado comorotina durante o tratamento periodontal. É evidente a necessidade deestudos adicionais, com metodologias mais precisas e reproduzíveis,para a elucidação da real interação da oclusão com os tecidosperiodontais.
Editorial
Authors: Adriane Cristina Kasprowicz
Published: April 2023

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Prevalence and Associated Factors of Toenail Onychomycosis Among
Patients with Diabetes in Jordan
Authors: Alrauosh Hesham , Ababneh Anas , Bakri Faris G. , Abujbara Mousa , Kanaan Hashem , Younes Nidal A.
Published: April 2023

Background:

Toenail onychomycosis is common in patients with diabetes and it can increase
the risk of secondary infections and foot complications. Despite several studies investigating
the prevalence and associated factors of toenail onychomycosis from different parts of the world,
there are no data from Jordan.

Objective:

To determine the prevalence and the associated factors of toenail onychomycosis among
patients with diabetes in Jordan.

Methods:

A cross-sectional study was conducted on 375 patients with diabetes at the National
Centre for Diabetes, Endocrinology, and Genetics in Amman, Jordan. Several socio-demographic
and health-independent variables including foot self-care practices were collected. Toenail onychomycosis
was assessed by a specimen culture and microscopic examinations. Descriptive and
inferential statistics were used for data analysis.

Results:

The prevalence of toenail onychomycosis was 57.6% (n=216). Multiple logistic regression
revealed four significant associated factors; the presence of neuropathy (β=1.87, p=0.02), being
an ex-smoker (β=2.69, p=0.01), being treated by both insulin and oral hypoglycemics drugs
(β=1.32, p=0.03), and using antibiotics in the last year (β=1.78, p=0.02).

Conclusion:

The prevalence of toenail onychomycosis among patients with diabetes in Jordan is
high. Regular foot screening and podiatric care are recommended especially among patients with
diabetic neuropathy, current treatment by insulin and oral hypoglycemics drugs, previous history of
smoking, and previous use of antibiotics.
Universiteit van het Noorden: vier eeuwen academisch leven in Groningen: Deel 3 De zakelijke universiteit 1945-2021
Authors: van Berkel Klaas
Published: April 2023

De Rijksuniversiteit Groningen is sinds het einde van de Tweede Wereldoorlog onherkenbaar veranderd. Van een kleine academische gemeenschap groeide de universiteit uit tot een modern bedrijf: ondernemend, marktgericht en internationaal georiënteerd. De verzakelijking, die begon met de oprichting van een Faculteit voor Economische Wetenschappen in 1948, stokte toen studenten en docenten in de jaren zestig en zeventig een ingrijpende democratisering wisten door de voeren. Maar na dit democratisch intermezzo kreeg de verzakelijking de wind weer volop in de zeilen. Digitalisering, de komst van duizenden buitenlandse studenten, de ruimtelijke expansie van de universiteit, de schaalvergroting van het onderzoek en de verkorting en verstrakking van de studie maakten dat de universiteit tegenwoordig in bijna niets meer lijkt op de universiteit die na de oorlog weer probeerde op te krabbelen. De vraag is wel: heeft de Groningse universiteit bij al deze veranderingen haar academisch karakter weten te behouden?
АНАЛІЗ ПАРАМЕТРІВ ДІАСТОЛІЧНОЇ ДИСФУНКЦІЇ ЛІВОГО ШЛУНОЧКА У ХВОРИХ НА ГІПЕРТОНІЧНУ ХВОРОБУ З СУПУТНІМ ЦУКРОВИМ ДІАБЕТОМ 2 ТИПУ
Authors: Князькова Ірина , Біловол Олександр , Дунаєва Інна , Кірієнко Олександр , Циганков Олександр , Кірієнко Денис
Published: April 2023

Мета дослідження. Провести аналіз особливостей діастолічної функції лівого шлуночка у хворих на гіпертонічну хворобу з супутнім цукровим діабетом 2 типу та без нього до та після комплексного лікування з включенням еплеренону 50 мг на добу та триметазидину 80 мг на добу.
Матеріали та методи дослідження. Обстежено 25 хворих на гіпертонічну хворобу (ГХ) та цукровий діабет 2 типу (ЦД2) в стані субкомпенсації (основна група) та 25 пацієнтів з ГХ II стадії без ЦД2 у віці від 35 до 65 років, що перебували на лікуванні в клініці ДУ «Національний інститут терапії імені Л.Т. Малої НАМН України». Контрольну групу склали 20 здорових осіб.
Статистичний аналіз даних виконали за допомогою пакету статистичних програм Statistica 8.0 (Stat Soft Inc, США), Microsoft office Excel 2003, з використанням стандартних методів.
Результати та висновки. Тримісячне лікування еплереноном і триметазидином сприяло нормалізації гемодинаміки і метаболічних процесів, призводило до покращення функціональних можливостей міокарду (підвищення швидкості розслаблення міокарду в діастолу), загальмування або припинення подальшого розвитку несприятливих змін кардіогемодинаміки у вигляді підвищення тиску наповнення лівого шлуночку та порушення геометричних параметрів серця. Вивчення параметрів діастолічної функції лівого шлуночка на етапі функціональних порушень міокарда необхідне з метою профілактики або зворотного розвитку серцевої недостатності у хворих на коморбідну патологію: гіпертонічну хворобу з супутнім цукровим діабетом 2 типу, що є запорукою поліпшення серцево-судинного прогнозу у такого контингенту пацієнтів. Проведене дослідження підтверджує необхідність своєчасної діагностики з метою уточнення механізмів розвитку серцевої недостатності у хворих з коморбідною патологією та проведення профілактичного лікування виявлених порушень за умов збереження стану субкомпенсації вуглеводного обміну.
Intentional Structured Opioid Monitoring Protocol: Responsible and Viable Opioid Deprescribing
Authors: M. Franks, MD Adam , S. McCann, MD Kevin , Velthouse, MD, MPH, MBA Kimberly , Sutphin, MPH Rich , M. Petrany, MD Stephen
Published: April 2023

INTRODUCTION Primary care providers are increasingly called to address the problem of treatment of non-malignant chronic pain with opioids, particularly in low resource areas. An Intentional Structured Opioid Management Protocol (ISOMP) is a primary care-based program shown to significantly decrease opioid burden. The development of sustainable programs that improve opioid-related outcomes is especially important in these low resource areas. METHODS A retrospective electronic health record review was conducted for financial data and billing practices for a cohort engaged in the ISOMP between 2011 and 2014. Data was analyzed for sustainability within macroscopic practice-wide and microscopic daily scopes. Further analysis was conducted on the implications of patients maintained on (Group A) and weaned from (Group B) opioids. Data was analyzed with STATA software. RESULTS ISOMP demonstrated decreased patient encounters numbers (-7.38%), increased total work relative value unit (RVU) (+7.73%), reduced no-show visits (-12.14%), and increased total reimbursement (+13.06%). Group A had fewer encounters (-6.41%) and increased work RVU (+42.95%). Group B had fewer encounters (-24.04%) but decreased work RVU (-17.56%). Significant decreases in encounters (-44.99%) and work RVUs (-47.39%) were seen after discontinuation of opioids. CONCLUSIONS Besides its previously documented opioid discontinuation rate, the ISOMP model was associated with fewer visits and better visit compli-ance. Sustainability was proven as neither global practice nor daily productivity was negatively impacted. Time-based coding for Group A offset losses seen in Group B productivity with savings directly related to speed of opioid wean