bluuebunny/crossref_metadata_2025 huggingface dataset:
‘What the public values...’ The stakeholder-oriented business model approach as a tool for planning and managing innovation in public and nonprofit management – A qualitative inquiry into public value creation in German healthcare
Authors: Znotka Matti , Brandt Florian , Lindenmeier Jörg , Dietrich Martin
Published: July 2019

In democratic environments, the integration of the public perspective is vital to the continuous legitimization and acceptance of publicly managed systems, as it justifies the organizations’ existence for the stakeholders who provide the financial support. An integration of the public perspective in the design of innovative business models requires an identification of citizens’ values to enable public managers and entrepreneurs to ascertain if their decisions have the potential to create value according to the public will. As healthcare in Germany is largely funded by the public, we asked the German public about crucial values in healthcare. Three value dimensions, ‘proper organization’, ‘skilled treatment’ and ‘social principles’, consisting of nine value categories, could be identified as potential guidelines.
The Relevance of Citizen Co-Creation for the Effectiveness of Public Health Campaigns: Results from the Evaluation of a HIV Prevention Campaign in Switzerland
Authors: Liberatore Florian , Schmelzer Sarah , Angerer Alfred
Published: July 2019

While decreasing public health budgets force campaign managers to spend money more wisely, many public health campaigns still use traditional communication channels and neglect the great potential of citizen co-creation, the active involvement of the target group. This article provides an overview of the issue of citizen co-creation in the context of public health campaigns and presents a case study of an HIV campaign in Switzerland as an example of applied citizen co-creation. The incremental effect of word of mouth on campaign effectiveness and efficiency is examined, showing how citizen co-creation can be quantified in the context of evaluating a campaign. Finally, the article suggests practical implications for the design and evaluation of future public health campaigns involving citizen co-creation.
Politicians as active and participating stakeholders – the case of gender budgeting in Austria
Authors: Korac Sanja , Moser Birgit , Rondo-Brovetto Paolo
Published: July 2019

This article looks at politicians as external stakeholders of the administration. Using the case of gender budgeting at the central government level in Austria, it analyzes the perception of politicians on how (well) gender perspectives have been introduced in the budgetary process, and how these stakeholders have actively participated in the administrations’ work. The study builds on interviews with members of the parliamentary budget committee and a qualitative analysis of budget documents. The results show that politicians perceive the administration as rather non-responsive to their active participation in introducing gender perspectives in the budgetary process.
Die Glaubwürdigkeit von Leistungsberichten aus Sicht der Bürger – eine erweiterte experimentelle Replikationsstudie
Authors: Saliterer Iris , Albrecht Nora
Published: July 2019

Der vorliegende Beitrag beschäftigt sich mit der Glaubwürdigkeit von kommunalen Leistungsberichten aus Sicht der Bürger. Die erweiterte experimentelle Replikationsstudie liefert neue Erkenntnisse zur Glaubwürdigkeit von vier unterschiedlichen Berichtsquellen, und der Frage, inwieweit die Ausprägung von Glaubwürdigkeitsfaktoren wie Kompetenz und Ehrlichkeit den empfundenen Wahrheitsgehalt von Leistungsinformationen beeinflussen. Die Ergebnisse zeigen, dass es zwischen privaten und öffentlichen Berichtsquellen signifikante Unterschiede in der wahrgenommenen Glaubwürdigkeit von Leistungsinformationen gibt, wobei sich diese vor allem auf den direkten Vergleich von politischer und unabhängiger Berichtsquelle zurückführen lassen. Insgesamt zeigt sich, dass Bürger den von unabhängigen Instituten veröffentlichen Leistungsberichten am meisten vertrauen, insbesondere, wenn sie diese als kompetent erachten.
Interdisziplinäre Konturen eines Verantwortungsbegriffs für das Recht
Authors: Windbichler Christine
Published: July 2019

Die Zuweisung rechtlicher Verantwortung ist in erster Linie eine Rechtsfrage. Grund und Grenzen solcher Zuschreibung gewinnen aber an Plausibilität und Konsistenz, wenn sie Erkenntnisse und Methoden anderer Disziplinen berücksichtigen und Alltagstheorien hinterfragen. U. a, Psychologie, Soziologie und Ökonomik können wertvolle Hilfen liefern. Beispiele sind die Unterscheidung von Korrelation und Kausalität, der Umgang mit dem (unvermeidlichen) Rückschaufehler sowie die Einschätzung legaler Handlungen, die kumulativ unerwünschte Folgen haben und deshalb Regulierung rechtfertigen.
Das Unternehmen als Subjekt und Objekt nichtfinanzieller Berichtspflichten
Authors: Kolter Max A. P.
Published: July 2019

Die Reichweite der neuen nichtfinanziellen Berichtspflichten nach der sog. CSR-Richtlinie ist weitgehend ungeklärt. Der Beitrag zeigt auf, dass die vorgeschriebene Berichtstiefe mit der Auslegung der „Geschäftstätigkeit des Unternehmens“ steht und fällt. Um dem gesetzgeberischen Leitbild des modernen Großunternehmens zur Umsetzung ins positive Recht zu verhelfen, wird ein Rundgang durch Rechtswissenschaft, Ökonomik und Soziologie unternommen, auf der Suche nach einer geeigneten „theory of the firm“. Mittels des gewonnenen Unternehmensbegriffs lassen sich die nichtfinanziellen Berichtspflichten zwar schärfen, dennoch bleiben die politischen Zielsetzungen zum Teil unerfüllt.
Poetry Writing as a Performative, Dialogical, and Revolutionary Act
Authors: Camozzi Daniela ,   Polish Academy of Sciences
Published: July 2019

Creative collective actions can have the potential of true performative utterances opening windows of opportunities for new realities to emerge, for new possible worlds to be created—the realm of the arts is the realm of the “possible.” Group poetry writing can be a performative, dialogic act, and a transformative, revolutionary one as well. Collective artistic creations can break the isolation that the capitalistic patriarchal system imposes on us, helping us connect with one another, giving us hope.
The Fiction of the Beautiful: Digital Eros
Authors: Parma Lorena Rojas ,   Polish Academy of Sciences
Published: July 2019

Love has always liked, as we can observe since the same lyrical beginnings, to show itself, proclaim itself, as if something vital was played in that revelation that, in a certain sense, does not stop being strange because we are talking about deep experiences of each one’s soul. Now, that showing, which has found a place of privilege, must be thought under the digital cloak that dresses Eros, and think about it, then, as digital Eros. From Plato, Eros is a desire for the beautiful, Eros loves the beautiful. Therefore, the showing itself beautiful of love, requires a reflection in relation with how we show ourselves beautiful, that is, how the possibilities of networks allow us to make, sculpt, elaborate for that purpose. Finally, this implies a revision of the fictitious and the authentic of us, what the networks allow of us.
Cognitive Empathy in the Works of Sam Harris
Authors: Bubnov Evgeniy ,   Polish Academy of Sciences
Published: July 2019

The article attempts to analyze unconscious cognitive empathy in Sam Harris’ discourse. Harris equates the theology of Abrahamic religions with ancient mythology. However, the expulsion of the Numinous into the sphere of the transcendent, made possible by monotheism, gave impetus to the study of nature and led to what Max Weber called the Disenchantment. This Disenchantment, firstly, led to the discrediting of ancient myths, and secondly, to the scientism of Harris and his like-minded people.
Post-Knowledge
Authors: Richmond Sheldon ,   Polish Academy of Sciences
Published: July 2019

The monopolization of our techno-scientific culture by digital information technology, the Technopoly has unintentionally resulted in the extinction of knowledge or postknowledge, by reducing knowledge to systems of symbols—formalized algorithmic hierarchies of symbol-systems without external reference; a totalistic virtuality, or real virtuality. The extinction of knowledge or post-knowledge has resulted in two mutually reinforcing situations. One situation is the rise of a new elite of technology experts. The other situation is the dummification of people. These two mutually reinforcing situations further result in an illegitimate role reversal between people and their machines. The machines become treated as smart; people become treated as dummies. The role reversal of machines and people reinforces the monopoly of digital technology over everything. The monopoly of digital techno-scientific culture, the Technopoly, becomes accepted without question and without criticism. However, there is a way to retrieve knowledge, and that way is through restoring the (Ionian) tradition of critical discussion within all our institutions. Critical discussion can be restored by increasing democratic participation in our techno-scientific culture, which amounts to implementing a Socratic social architecture.
Czarnocka’s Conception of Symbolic Truth
Authors: Mitias Michael H. ,   Polish Academy of Sciences
Published: July 2019

The proposition I elucidates and defend in this paper is that the Transcendent can be an object of genuine knowledge and that the knowledge the philosophical mystic claims of it is symbolic in nature. In my endeavor to achieve this aim I rely on Małgorzata Czarnocka’s conception of symbolic truth as a model of explanation. I am inclined to think that, as a model of explanation, this conception sheds ample light on the possibility of having a cognitive experience of the Transcendent. The paper is composed of four parts. The first part raises the question of the Transcendent as an object of knowledge. The second part advances a brief analysis of the main elements of Czarnozka’s conception of symbolic truth with special emphasis on her view of human nature. The third part explicates the sense in which the conception of symbolic truth functions as a model of explanation. The fourth part analyzes the conditions under which the Transcendent can be an object of knowledge.
How Is Science Universal?
Authors: Czarnocka Małgorzata ,   Polish Academy of Sciences
Published: July 2019

I investigate the universality of science as perceived in epistemological conceptions and in sociology of science, as well as claims about the anti-universal character of science. In this, I distinguish two kinds of universality of science: epistemic and global cultural/social, and in the latter also the global universality of the basic level of science. I attempt to show that epistemology views science as universal in its basic aspects relating to knowledge, its object, subject and cognitive values as well as methods, which, according to the epistemological meta-theses, are necessary for scientific validity and autonomy. I also draw attention to the fact that sociologised, multiculturally-oriented approaches to science are wrong to hold it for irrevocably anti-universal and exclusively a part of Western culture. I suggest instead the perspective of basic-level global universalism, where science is seen to grow out of a cultural base common to all cultures, which provides the criteria for weak rationality, weak empiricism and methodology and determines the nomological character of cognition. Finally, I trace the evolution of universality from a property of science to a value, and ask about the meaning of this property-cum-value for the human world.
Problems of Deep Disagreement
Authors: Karimov Artur Ravilevich ,   Polish Academy of Sciences
Published: July 2019

Deep disagreement is a disagreement about epistemic principles, pertaining to the methods of justification and argumentation. Relying on Ludwig Wittgenstein’s conceptual metaphor of “hinges,” researchers arrive at the conclusion that deep disagreement cannot be resolved. This conclusion leads to relativism in the theory of argumentation. The aim of the article is to show that in the situation of deep disagreement it is theoretically possible to ascertain which of the positions of the participants of the argument has a better epistemic status, and hence, is argumentatively virtuous.
Manuel Terol, In Memoriam
Authors: Torres del Moral Antonio
Published: July 2019

Manuel Terol, In Memoriam
Enrique Álvarez Conde, In Memoriam
Authors: Torres del Moral Antonio
Published: July 2019

Enrique Álvarez Conde, In Memoriam
Mariano García Canales, In Memoriam
Authors: Torres del Moral Antonio
Published: July 2019

Mariano García Canales, In Memoriam
Los mecanismos jurídicos de lucha contra la discriminación: aportaciones para la configuración del Derecho Antidiscriminatorio
Authors: Esparza-Reyes Estefanía , Díaz Revorio Francisco Javier
Published: July 2019

Desde hace algunos años, ha tomado fuerza la existencia de una rama específica del Derecho denominada Derecho Antidiscriminatorio. Sin embargo, no existe un tratamiento sistemático de tal disciplina, por lo cual se requiere de un análisis acabado de sus postulados centrales, así como de los mecanismos de los que se vale para enfrentar el fenómeno de la discriminación. Los Estados, en ocasiones inspirándose en la regulación internacional sobre la materia, han utilizado diversas herramientas para combatir la discriminación con mayor o menor éxito, aunque en ocasiones tales medidas no se visualizan como formas de protección. Con todo, los mecanismos de lucha contra la discriminación suelen compartir rasgos comunes que hace plausible sistematizarlos bajo categorías de análisis válidas para diversos ordenamientos jurídicos. Solo analizando estos mecanismos mediante categorías, será posible formarse una idea cabal del estado del Derecho Antidiscriminatorio en un sistema jurídico dado y, de esta forma, contribuir a su desarrollo.
¿Resulta oportuno dar un tratamiento jurídico a la gestación subrogada en nuestro país?
Authors: Matia Portilla Francisco Javier
Published: July 2019

Este trabajo tiene su origen en una paradoja: aunque la gestación subrogada constituye en nuestro país un contrato nulo y que puede originar responsabilidades penales, hoy vienen más niños españoles a este mundo siguiendo esta técnica que la de la adopción. Dea ahí que siga teniendo sentido preguntarse si resulta oportuno dar un tratamiento jurídico a la gestación subrogada. En el estudio se recuerdan las posiciones manejadas por los partidos políticos, y la evolución de la cuestión en Francia y España, también en lo que afecta a la inscripción en el registro civil español de menores nacidos fuera de nuestras fronteras y en los derechos vinculados a su cuidado. Se da especial relevancia a las resoluciones del Tribunal de Estrasburgo (además de las clásicas Labasse y Manesson, la reciente opinión consultiva emitida el pasado mes de abril) y del Tribunal de Justicia de la Unión Europea. Tras un profundo analisis legal, jurisprudencial y doctrinal se defiende la conveniencia de realizar una regulación garantista de la gestación subrogada en nuestro país.
Hacia la consolidación de la constitucionalidad de la educación diferenciada. A propósito de la sentencia del Tribunal Constitucional 31/2018
Authors: Báez Serrano Rafael
Published: July 2019

La educación diferenciada es un modelo pedagógico que frecuentemente ha generado múltiples controversias con relación a su potencial actitud discriminatoria y las dudas sobre si ayuda a la consecución del pleno desarrollo de la personalidad del alumno como puede hacerlo la educación mixta, tal y como obliga el ideario educativo constitucional. Más problemas aún ha causado la posibilidad de que los centros privados que imparten enseñanzas con este régimen accedan a financiación pública. En este documento vamos a analizar la regulación de la educación diferenciada, para conocer en primera instancia la situación legislativa de dicho modelo pedagógico, para poder entrar a valorar posteriormente su adecuación al texto constitucional sin que constituya actitud discriminatoria para niñas o niños así como la necesidad de su carácter militante en relación al ideario educativo constitucional, todo ello siguiendo muy de cerca la reciente sentencia del Tribunal Constitucional que avala este tipo de modelo pedagógico y las ayudas económicas de los poderes públicos a los centros en los que se imparte debido a su legítimo ideario propio.
Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology
Authors: Ajani Jaffer A. , D’Amico Thomas A. , Bentrem David J. , Chao Joseph , Corvera Carlos , Das Prajnan , Denlinger Crystal S. , Enzinger Peter C. , Fanta Paul , Farjah Farhood , Gerdes Hans , Gibson Michael , Glasgow Robert E. , Hayman James A. , Hochwald Steven , Hofstetter Wayne L. , Ilson David H. , Jaroszewski Dawn , Johung Kimberly L. , Keswani Rajesh N. , Kleinberg Lawrence R. , Leong Stephen , Ly Quan P. , Matkowskyj Kristina A. , McNamara Michael , Mulcahy Mary F. , Paluri Ravi K. , Park Haeseong , Perry Kyle A. , Pimiento Jose , Poultsides George A. , Roses Robert , Strong Vivian E. , Wiesner Georgia , Willett Christopher G. , Wright Cameron D. , McMillian Nicole R. , Pluchino Lenora A.
Published: July 2019

Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Squamous cell carcinoma is the most common histology in Eastern Europe and Asia, and adenocarcinoma is most common in North America and Western Europe. Surgery is a major component of treatment of locally advanced resectable esophageal and esophagogastric junction (EGJ) cancer, and randomized trials have shown that the addition of preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival. Targeted therapies including trastuzumab, ramucirumab, and pembrolizumab have produced encouraging results in the treatment of patients with advanced or metastatic disease. Multidisciplinary team management is essential for all patients with esophageal and EGJ cancers. This selection from the NCCN Guidelines for Esophageal and Esophagogastric Junction Cancers focuses on recommendations for the management of locally advanced and metastatic adenocarcinoma of the esophagus and EGJ.
Spatial distribution of caatinga plants in the environment of a thermelectric
Authors: Cerqueira Joaci dos Santos , Albuquerque Helder Neves de , Sousa Francisco de Assis Salviano de
Published: July 2019

The vegetation of the Caatinga of the Brazilian semiarid of the xerophilous type is usually found between shallow and poorly permeable soils, which is constantly affected by irregular deforestation. In this context, the objective of this work was to identify the floristic species of a thermoelectric plant located in the semi - arid Paraibano region, in addition to diagnosing the ecological integrity of the arboreal remnants of this area. The Phytosociological Survey of this study was carried out in an area with 20.1ha, with sampling in six plots. The processing of phytosociological data was carried out using Mata Nativa 4.0 software. The identification of floristic species was evaluated through the basal area, density, frequency, dominance, cover value and importance value. For the analysis of the data, the similarity between the species was compared by the Jaccard index, the floristic similarity matrix was used for cluster analysis and dendrogram generation. The floristic species inventoried, totaled 280 individuals and the family that had the largest representative was the Euphorbiaceae. It was observed that the studied area is in process of ecological succession, due to the physical pressures of the residents of the surroundings, with exploitation of natural resources of uncontrolled form causing, deforestation, burnings, among others. It is verified that floristic inventories are of great importance to monitor biodiversity, as well as to draw up, goals of efficient environmental management and serve as a tool aimed at the conservation of the Caatinga species.
An ambiguous N-terminus drives the dual targeting of an antioxidant protein Thioredoxin peroxidase (TgTPx1/2) to endosymbiotic organelles inToxoplasma gondii
Authors: Mastud Pragati , Patankar Swati
Published: July 2019

Toxoplasma gondiiharbors two endosymbiotic organelles: a relict plastid, the apicoplast, and a mitochondrion. The parasite expresses an antioxidant protein, thioredoxin peroxidase 1/2 (TgTPx1/2), that is dually targeted to these organelles. Nuclear-encoded proteins such as TgTPx1/2 are trafficked to the apicoplast via a secretory route through the endoplasmic reticulum (ER) and to the mitochondrion via a non-secretory pathway comprising of translocon uptake. Given the two distinct trafficking pathways for localization to the two organelles, the signals in TgTPx1/2 for this dual targeting are open areas of investigation. Here we show that the signals for apicoplast and mitochondrial trafficking lie in the N-terminal 50 amino acids of the protein and are overlapping. Interestingly, mutational analysis of the overlapping stretch shows that despite this overlap, the signals for individual organellar uptake can be easily separated. Further, deletions in the N-terminus also reveal a 10 amino acid stretch that is responsible for targeting the protein from punctate structures surrounding the apicoplast into the organelle itself. Collectively, results presented in this report suggest that an ambiguous signal sequence for organellar uptake combined with a hierarchy of recognition by the protein trafficking machinery drives the dual targeting of TgTPx1/2.
Bivariate Copula Based Models for the Dependence of Maternal Mortality Ratio(MMR) on Gross Domestic Product(GDP) and Total Fertility Rate(TFR)
Authors: Okyere Gabriel Asare , Zaachi Godfred , Owusu-Mintah Emmanuel K. , Amponsah Charles K.
Published: July 2019

Global progress towards reducing high Maternal Mortality Rates (MMR) turned to be defeated by high maternal mortalities originating from developing countries. In rural Ghana, the lack of logistics, medical and laboratory equipment are among other key factors responsible for the high MMR despite several interventions structured to curb this menace. Improvement in the country's health care delivery will require substantial investment into maternal and child health especially, in order to meet the national SDG target on MMR.This paper demonstrates societal benets of investment in maternal and child health in order to stimulate stakeholders interest in resource mobilization by the correlation of MMR with such economic and demographic indicators as Gross Domestic Product (GDP) and Total Fertility Rate (TFR). The underlying probability distributions for MMR, TFR and GDP were determined using the corrected Akaike Information Criteria (cAIC) with parameters estimated via the maximum likelihood framework. MMR and TFR showed a positive association (0.83) whilst an inverse relation exist between MMR and GDP (-0.67) and TFR and GDP (-0.76). The contour and joint density plots from appendix A and B indicate a strong lower tail dependence for the bivariate Frank copula with Gamma and Lognormal margins whereas the Gumbel copula with Gamma and Lognormal marginsshows strong upper tail dependence. Correlation gures tend to suggests that improved GDP as a consequence of improved socio-economic conditions of a Ghanaian mother tend to reduce Maternal Mortalities whilst increased fertility rates turn to increase MMR. Generally, evidence has been drawn to improvement in GDP.
Numerical Optics Soliton Solution of the Nonlinear Schrödinger Equation Using the Laplace and the Modified Laplace Decomposition Method
Authors: El-Horbaty M. M. , Ahmed F. M.
Published: July 2019

In this paper, the Laplace decomposition method (LDM) and some modification, namely the Modified Laplace decomposition method (MLDM), are adopted to numerically investigate the optic soliton solution of the nonlinear complex Schrödinger equation (NLSE). The obtained results demonstrate the reliability and the efficiency of the considered methods to numerically approximate such initial value problems (IVPs).
Effectiveness of Teaching Lazarus Multifaceted Approach on Mental Health of the Elderly
Authors: Parisa Mahoory, , Naghi Aghdasi, Ali , Mirmahmood Seyyedvalilou,
Published: July 2019

The purpose of the present study was to investigate the effectiveness of teaching Lazarus multifaceted approach on mental health and well-being of elderly people in Tabriz city. The method of this research is applied. For this purpose, among all elderly women covered by health care institutions or in nursing homes of the elderly, 24 women The elderly of Tabriz city in 2012 and in two experimental and control groups (12 people) were selected by random sampling method. The experimental group was trained for 2 months in 10 sessions of 90 minutes in the Lazarus multifaceted training sessions and the control group did not receive any intervention. Oxford Happiness Questionnaire and Mental Health Questionnaire (GHQ) in both groups were performed and the results were reported in SPSS20 software using one-variable covariance test. Findings showed that teaching Lazarus' multifaceted approach on the happiness of elderly women in Tabriz has a significant level of P = 0.012, as well as teaching Lazarus multifaceted approach on mental health of elderly women in Tabriz at a significant level of P Has an impact. Therefore, we conclude that teaching Lazarus' multifaceted approach will increase the health and improve the mental health of the elderly.
Analysis of Teacher-written Corrective Feedback in Second Language Writing Pedagogy in Secondary Schools, Bulilima, Zimbabwe
Authors: Muchemwa Stella , Amimo Catherine , Allida Vencie
Published: July 2019

This study investigated the teachers’ practice on written corrective feedback as well as the students’ response to it in a bid to find practical solutions to the problem of low performance in English composition writing at “O” Level in Zimbabwe. The study sought to find out the nature of corrective feedback that “O” Level students get from their composition teachers and how these students respond to it. In this qualitative research, seven informants (“O” Level students) were interviewed; the researchers used a semi-structured interview schedule to address them and their English exercise books were also analyzed using a document analysis guide designed by the researchers. The study concluded that the composition teacher marked the compositions thoroughly highlighting most of the errors for students’ benefit. The teacher’s focus on feedback was in line with the syllabus demands. The teacher also satisfied the Feed Up, Feed Back and the Feed Forward types of effective feedback. She had strength on mark allocation which acted as student guide to their stance in composition writing. However, although the students largely benefited from the teacher’s corrective written feedback as well as the oral feedback, some of them failed to get the maximum benefit because they could not understand the correction codes. It is therefore imperative for composition teachers to provide students with a correction code elaboration whenever using a marking correction code.
Effects of time pressure on strategy selection and strategy execution in forced choice tests
Authors: Orthey Robin , Palena Nicola , Vrij Aldert , Meijer Ewout , Leal Sharon , Blank Hartmut , Caso Letizia
Published: July 2019

We examined the effects of cognitive load on the strategy selection in the forced choice test (FCT) when used to detect hidden crime knowledge. Examinees (N = 120) with and without concealed knowledge from a mock crime were subjected to an FCT either under standard circumstances or cognitive load. Cognitive load was implemented through time pressure. The FCT distinguished examinees with concealed knowledge from those without better than chance in both conditions, but the counterstrategies did not differ between conditions. Further investigation revealed that time pressure did affect examinees' ability to follow their intended counterstrategy to produce randomized test patterns, which constitutes an effective counterstrategy in the FCT. Hence, time pressure lowered the success rate of effective counterstrategies, but not their incident rates. Further disambiguation of various cognitive load manipulations and their effects on strategy selection and execution is needed.
Terahertz Sensing Based on Metasurfaces
Authors: Beruete Miguel , Jáuregui‐López Irati
Published: July 2019

The terahertz (THz) band has very attractive characteristics for sensing and biosensing applications, due to some interesting features such as being a non‐ionizing radiation, very sensitive to weak interactions, thus, complementing typical spectroscopy systems in the infrared. However, a fundamental drawback is its relatively long wavelength (10–1000 µm) which makes it blind to small features, hindering seriously both thin‐film and biological sensing. Recently, new ways to overcome this limitation have become possible thanks to the advent of metasurfaces. These artificial structures are planar screens usually made of periodic metallic resonators and whose electromagnetic response can be controlled at will by design. This design freedom allows metasurfaces to surpass the restrictions of classical THz spectroscopy, by creating fine details comparable to the size of the thin films or microorganisms under test. The strong field concentration near these small metasurface details at resonance makes them highly sensitive to tiny variations in the nearby environment, allowing for an enhanced detection more accurate than classical THz spectroscopy. The main advances in THz metasurface sensors from a historical as well as application‐oriented perspective are summarized. The focus is put mainly on thin‐film and biological sensors, with an aim to cover the most recent advances in the topic.
Fluorescence Detection and Dissociation of Amyloid‐β Species for the Treatment of Alzheimer's Disease
Authors: Lv Guanglei , Shen Yang , Zheng Wubin , Yang Jiajia , Li Chunxia , Lin Jun
Published: July 2019

Alzheimer's disease (AD) is one of the most prevalent forms of neurodegenerative disease. It is well established that the β‐amyloid peptide (Aβ) species existing in several forms, such as soluble monomers, oligomers, and insoluble aggregates, play an essential role in the pathophysiology of AD. Therefore, much effort has been made to specifically detect Aβ species and to inhibit Aβ aggregation for the treatment of AD. In this review, an overview of recent advances in detecting different Aβ forms mainly containing Aβ aggregates, Aβ oligomers, and Aβ protofibrils is provided. In addition, photodynamic therapy (PDT) and photothermal therapy (PTT) are considered to be promising modalities for the treatment of AD because of the minimal invasiveness and high spatial selectivity. Herein, the strategies of inhibiting Aβ aggregation and dissociating Aβ aggregates using PDT, PTT, and Aβ inhibitors for the treatment of AD are summarized.
Metal–Organic Frameworks in Modern Physics: Highlights and Perspectives
Authors: Mezenov Yuri A. , Krasilin Andrei A. , Dzyuba Vladimir P. , Nominé Alexandre , Milichko Valentin A.
Published: July 2019

Owing to the synergistic combination of a hybrid organic–inorganic nature and a chemically active porous structure, metal–organic frameworks have emerged as a new class of crystalline materials. The current trend in the chemical industry is to utilize such crystals as flexible hosting elements for applications as diverse as gas and energy storage, filtration, catalysis, and sensing. From the physical point of view, metal–organic frameworks are considered molecular crystals with hierarchical structures providing the structure‐related physical properties crucial for future applications of energy transfer, data processing and storage, high‐energy physics, and light manipulation. Here, the perspectives of metal–organic frameworks as a new family of functional materials in modern physics are discussed: from porous metals and superconductors, topological insulators, and classical and quantum memory elements, to optical superstructures, materials for particle physics, and even molecular scale mechanical metamaterials. Based on complementary properties of crystallinity, softness, organic–inorganic nature, and complex hierarchy, a description of how such artificial materials have extended their impact on applied physics to become the mainstream in material science is offered.
MAP1B related syndrome: Case presentation and review of literature
Authors: Julca Diana M. , Diaz Jullianne , Berger Seth , Leon Eyby
Published: July 2019

The microtubule‐associated protein 1B (MAP1B) gene serves an important role in axonal growth and brain development. Its expression is known to be elevated in regions that retain high brain plasticity and is regulated by the fragile X mental retardation protein. MAP1B mutations have recently been associated with a phenotype including periventricular nodular heterotopia (PVNH), intellectual disability (ID), seizures, and dysmorphic features. We describe a child presenting with global developmental delays, ID, microcephaly, short stature, seizures, dysmorphic features, and prenatal alcohol exposure with a de novo nonsense MAP1B mutation (c.2035G>T, p.Glu679X) detected on whole exome sequencing (WES). His brain MRI showed PVNH and dysgenesis of the corpus callosum. While significant prenatal alcohol exposure could have modified his phenotype, we believe that this patient presents with features that cannot be explained by fetal alcohol exposure alone. This is the first case report that describes dysmorphic features associated with MAP1B mutations in detail along with supporting pictures and review of previous reported phenotypes. This case not only highlights the value of WES as a screening tool for unrecognized syndromes, but also supports the need for a better description of the phenotype associated with newly detected genetic syndromes by molecular screening.
The service system challenges of work with juvenile justice involved young people in the Hunter Region, Australia
Authors: Blakemore Tamara , Agllias Kylie , Howard Amanda , McCarthy Shaun
Published: July 2019

Current policies suggest that collaborative approaches are core to working effectively with juvenile justice involved young people. However, there is little research examining the workings of multi‐agency and collaborative endeavours in this field, or the experiences of the human service workers facilitating these connections. This paper reports on qualitative research that resulted from the Juvenile Justice and Education Equity in the Hunter Region project. Thirty‐eight human service workers were interviewed about their perceptions of the workings, strengths and challenges of the service system that supports young people who come into contact with the Children's Court in the Lower and Upper Hunter regions of New South Wales. Data analysis revealed three key themes related to (1) service gaps, cycles and maelstrom; (2) pursuing authentic service engagement; and (3) insider–outsider dynamics in service provision. Findings are discussed in relation to emerging practice and research agendas.
Development and validation of a nomogram for prognosis of sinonasal squamous cell carcinoma
Authors: Quan Huatao , Yan Li , Zhang Haiyan , Zou Lifen , Yuan Wei , Wang Shengzi
Published: July 2019

Background

Sinonasal squamous cell carcinoma (SNSCC) is a rare malignancy with varied outcomes. The aim of this study was to develop a nomogram for predicting survival of patients with SNSCC.

Methods

From the Surveillance, Epidemiology, and End Results database, we identified 1766 patients diagnosed with SNSCC between 2004 and 2015. Patients were randomly separated into a training set and a validation set in 4:1 ratio. An external validation was also performed by a set of 74 SNSCC patients who had been treated in our department. We used the training set to build a nomogram based on stratified multivariable Cox proportional hazard models for predicting overall survival. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index and calibration curve.

Results

Based on 1412 cases of the training cohort, our Cox regression analysis revealed that age, marital status, primary site, differentiation, T stage, N classification, M stage, and treatment modalities were associated with overall survival. A nomogram was established based on the results of multivariate analysis. The C‐index values of the nomogram for predicting survival were superior to those of the tumor‐node‐metastasis staging system (0.745 vs 0.679 in the training cohort, 0.752 vs 0.656 in the validation set, and 0.678 vs 0.596 in the external validation set). The calibration plots demonstrated good consistency between the predicted and observed results.

Conclusion

We have developed a nomogram to accurately predict the clinical outcomes of SNSCC patients. This model was effective and can help clinicians to improve patient counseling.
A case series of the dynamics of lipid mediators in patients with sepsis
Authors: Hamaguchi Mitsuhide , Wu Heng Ning , Tanaka Masahiro , Tsuda Noriko , Tantengco Ourlad Alzeus Gaddi , Matsushima Tomohide , Nakao Takami , Ishibe Takuya , Sakata Ikuhiro , Yanagihara Itaru
Published: July 2019

Background

Bioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls.

Case Presentation

Four patients with a Sequential Organ Failure Assessment (SOFA) score of <7 recovered from sepsis. One patient with SOFA score of 12 on day 7 died on day 21. In the fatal case, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, and linoleic acid‐derived lipid mediators, including 9‐hydroxyoctadecadienoic acid (9‐HODE), 13‐HODE, 9,10‐dihydroxy‐12‐octadecenoic acid (9,10‐DiHOME), and 12,13‐DiHOME, were elevated on day 1. Increase in anti‐inflammatory prostaglandin E1 ethanolamide together with persistently lower transcription level of FAAH mRNA was detected on day 7 in the fatal case.

Conclusion

Lipidomic analysis on day 1 revealed elevated linoleic acid metabolites, whereas on day 7, elevated prostaglandin E1 ethanolamide and low level of FAAH mRNA transcription were observed in the fatal case of sepsis.
Redox‐Inert Fe3+ Ions in Octahedral Sites of Co‐Fe Spinel Oxides with Enhanced Oxygen Catalytic Activity for Rechargeable Zinc–Air Batteries
Authors: Wang Xiao‐Tong , Ouyang Ting , Wang Ling , Zhong Jia‐Huan , Ma Tianyi , Liu Zhao‐Qing
Published: July 2019

Bimetallic cobalt‐based spinel is sparking much interest, most notably for its excellent bifunctional performance. However, the effect of Fe3+ doping in Co3O4 spinel remains poorly understood, mainly because the surface state of a catalyst is difficult to characterize. Herein, a bifunctional oxygen electrode composed of spinel Co2FeO4/(Co0.72Fe0.28)Td(Co1.28Fe0.72)OctO4 nanoparticles grown on N‐doped carbon nanotubes (NCNTs) is designed, which exhibits superior performance to state‐of‐the‐art noble metal catalysts. Theoretical calculations and magnetic measurements reveal that the introduction of Fe3+ ions into the Co3O4 network causes delocalization of the Co 3d electrons and spin‐state transition. Fe3+ ions can effectively activate adjacent Co3+ ions under the action of both spin and charge effect, resulting in the enhanced intrinsic oxygen catalytic activity of the hybrid spinel Co2FeO4. This work provides not only a promising bifunctional electrode for zinc–air batteries, but also offers a new insight to understand the Co‐Fe spinel oxides for oxygen electrocatalysis.
Glycine‐functionalized reduced graphene oxide for methylene blue removal
Authors: Wang Chubei , Ma Guoyang , Zhou Jianwei , Zhang Mingliang , Ma Xinfeng , Duo Fangfang , Chu Liangliang , Huang Jianxin , Su Xinmei
Published: July 2019

Glycine‐functionalized reduced graphene oxide (GRGO) was prepared through the reaction of glycine and chlorine‐functionalized reduced graphene oxide. The product was characterized by SEM, HRTEM, IR, Raman, and XPS. The nitrogen content (8.28%) was high in product, peak at 285.8 eV was assigned to the C–N bond, which implied that the chlorine residues in raw material were substituted by amine group of glycine. The intensity ratio of D and G peak was about 1.5, which also implied that more saturated carbon atoms were present in the product. Results of SEM, IR, and XPS confirmed that glycine molecules were attached to graphene sheets. Compared with reduced graphene oxide (61.5 mg/g) and active carbon (45.2 mg/g), GRGO had a good adsorption capacity (98.9 mg/g) for methylene blue. The adsorption process was fitted to three kinetic models and three adsorption isotherm models. The adsorption process complied with pseudo‐second order kinetic model and Langmuir model.
Mechanism of nickel extraction from sulfuric acid medium by synthesized α‐aminophosphonate derivative
Authors: He Dongmei , Zeng Li , Zhang Guiqing , Li Qinggang , Guan Wenjuan , Cao Zuoying , Wu Shengxi
Published: July 2019

A new compound, α‐aminophosphonate derivative containing pyridine ring (PPDE), was designed and synthesized as an extractant for the separation of nickel from metal impurities. Over 94.5% of Ni (II) extraction from sulfuric acid solution was achieved by using PPDE with an equilibrium pH of 4.02. Meanwhile, high separation coefficients of 23.8 for Ni to Co, 84.9 for Ni to Mn, 254.1 for Ni to Ca and 696.7 for Ni to Mg, respectively, were obtained. It was noted that PPDE exhibited an excellent regenerability, and the extraction of Ni with the recycled organic phase ranged from 92.5% to 93.9% during six circulations. The extracted nickel complex was determined as [Ni (PPDE)2(DNNSA−)2(H2O)4], which was supported by the data obtained from Fourier transform‐infrared, UV–Vis and electrospray ionization‐mass spectrometry spectra.
Synthesis and characterization of a novel highly phosphonated water‐insoluble polymer
Authors: Alter Christian , Neumann Beate , Stammler Hans‐Georg , Hoge Berthold
Published: July 2019

A novel polymer, functionalized by tetrafluoroaryl phosphonic acid units, was prepared by free‐radical polymerization of the corresponding styrene monomer. The obtained polymer was analyzed by gel permeation chromatography, differential scanning calorimetry, and spectroscopy (NMR, IR). Ion exchange capacity of the water‐insoluble polymer was determined in methanol solution by titration with 0.1M NaOH. The proton conductivity of the polymer of 9.91 × 10−7 S cm−1 as disclosed by electrochemical impedance spectroscopy renders this polymer a promising candidate for solid electrolyte applications or as a water‐insoluble dopant for proton exchange membrane applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48235.
Materiality in information environments: Objects, spaces, and bodies in three outpatient hemodialysis facilities
Authors: Veinot Tiffany C. , Pierce Casey S.
Published: July 2019

The materiality of information environments, and its role in information behavior, has received little attention. We present an ethnographic study involving 156 hours of observation and 28 patient interviews in outpatient hemodialysis facilities. Using an extended “Semiotic Framework for Information Systems Research,” the findings show that objects, spaces, and bodies were integral to 6 sociomaterial layers of facility information environments: the physical, empiric, syntactic, semantic, pragmatic, and social world. Objects of importance in the information environments included dialysis machines, instruments, records, paper documents, televisions, furniture, thermostats, lighting, and personal possessions. Spatial features, including compartmentalization, displays, distance, proximity, and spatially‐grounded routines, also constituted information environments. The information environments were also shaped by patient immobility, bodily discomforts, and orientation to bodily states. Each sociomaterial layer introduced enablers and constraints to information access, flow, and acceptance; these combined to construct patients primarily as passive recipients of information rather than active seekers and producers of information. A sociomaterial perspective and related focus on objects, spaces, and bodies offers a lens for professional information practice. We contribute information environment design guidance to facilitate such practice and stress that the value of certain sources and types of information can be materially encoded in an environment.
A Study of Graphene‐Based Copper Catalysts: Copper(I) Nanoplatelets for Batch and Continuous‐Flow Applications
Authors: De Angelis Sonia , Franco Mario , Triminì Alessandra , González Ana , Sainz Raquel , Degennaro Leonardo , Romanazzi Giuseppe , Carlucci Claudia , Petrelli Valentina , de la Esperanza Alejandro , Goñi Asier , Ferritto Rafael , Aceña José Luis , Luisi Renzo , Cid M. Belén
Published: July 2019

The use of graphene derivatives as supports improves the properties of heterogeneous catalysts, with graphene oxide (GO) being the most frequently employed. To explore greener possibilities as well as to get some insights into the role of the different graphenic supports (GO, rGO, carbon black, and graphite nanoplatelets), we prepared, under the same standard conditions, a variety of heterogeneous Cu catalysts and systematically evaluated their composition and catalytic activity in azide–alkyne cycloadditions as a model reaction. The use of sustainable graphite nanoplatelets (GNPs) afforded a stable CuI catalyst with good recyclability properties, which are compatible with flow conditions, and able to catalyze other reactions such as the regio‐ and stereoselective sulfonylation of alkynes (addition reaction) and the Meerwein arylation (single electron transfer process).
Zigzag‐Helix Transformation of Expanded Polyvaline Induced by Racemization
Authors: Okamura Taka‐aki , Tsubouchi Kyoko , Onitsuka Kiyotaka
Published: July 2019

Biological macromolecules are essentially homochiral. For example, proteins mostly consist of l‐amino acids. What happens when a chiral molecule meets itself in a mirror? For expanded polyvaline, zigzag‐helix transformation occurs. In this study, expanded polyvalines containing bis(pyridine)silver(I) moieties were synthesized and isolated as single crystals. The molecular structures were determined by X‐ray analysis, which revealed that chiral expanded poly(l‐valine) and poly(d‐valine) form zigzag chains. However, racemic mixture of these molecules form left‐ and right‐handed 41 helices that retain the original sequences. These secondary structures can be transformed by only flipping the C‐terminal amide plane for each unit, which is reminiscent of the relationship between an α‐helix and a β‐strand. Such expanded polypeptides can be built up into expanded protein, forming a tailor‐made three‐dimensional structure, which will lead to new functions.