bluuebunny/crossref_metadata_2025 huggingface dataset:
Cross-Species Genetic Marker Adaptation: Enhancing Genetic Defect Screening in Water Buffaloes Using Cattle Genetic Markers
Authors: Paraguison-Alili Rubigilda , Cacho-Rubia Roxan Grace , Flores Ester B. , Mingala Claro N.
Published: April 2024

Genetic defect screening plays a fundamental role in advancing the livestock industry by systematically identifying inherited aberrations in various animal species. This study applies DNA markers originally established for screening genetic defects in cattle, such as Bovine leukocyte adhesion deficiency (BLAD), Deficiency of uridine monophosphate synthase (DUMPS), Citrullinemia, and Freemartin, to water buffaloes. Evaluating genomic relatedness between cattle and water buffaloes provides insights into leveraging well-established genetic information from cattle. A combination of PCR and Restriction Fragment Length Polymorphisms (RFLP) was employed to identify inherited heterozygous and recessive allele conditions. DNA sequencing validated PCR products, confirming specific base changes. Notably, a lethal mutation in cattle's BLAD was identified in normal buffaloes, raising questions about the suitability of established target gene markers for water buffaloes. However, the study highlights the efficacy of cattle gene markers for DUMPS, Citrullinemia, and Freemartinism in screening genetic defects in water buffaloes. This research establishes a standardized molecular method for breeders, facilitating the identification of at-risk animals and carriers to eliminate recessive defect genes in the Philippine livestock industry.
Identification of a novel favorable STAD subtype based on multi-omics data Integration
Authors: Dai Hui , Ren Jing , Wang Chun , Zhang Haotian , Lv Xinhui , Yang Jiyuan , Wang Xudong
Published: April 2024

Gastric cancer remains a leading cause of cancer-related deaths with considerable heterogeneity among patients. Accurate classifications play a pivotal role in prognosis prediction and personalized therapeutic strategies. Considering the practicality of typing and its closer clinical relevance, in this study, we leveraged multi-omics data, specifically transcriptomics RNA-sequencing (mRNA) and DNA methylation data from the TCGA-STAD cohort, for clustering analysis. The integration of multi-omics data concerning prognosis facilitated cluster analysis through the implementation of ten clustering algorithms. A total of 359 gastric cancer (GC) samples were collected and categorized. Moreover, external validation datasets from diverse sequencing technologies corroborated the robustness of the clustering model. The relationships between the separate subgroups and clinical pathological characteristics, immune infiltration characteristics, immune checkpoint, genomic mutation and so on were meticulously examined. Meanwhile, potential responses to immunotherapy and chemotherapy were also assessed to enhance the clinical applicability of the molecular subtypes. Three subtypes (CS1, CS2, and CS3) were identified for gastric cancer, and exhibiting distinct prognostic status, activation of cancer-related pathways, TME compositions, immune checkpoints, sensitivity to chemotherapy and immunotherapy.
Preparation and characterization of copper ferrite functionalized graphitic carbon nitride nanocomposite as an efficient and reusable catalyst for synthesis of spirooxindol quinazolinone derivatives
Authors: Shaabani Raheleh , Naeimi Hossein
Published: April 2024

In this study, CuFe2O4/g-C3N4 nanocomposite was fabricated and characterized by using various techniques including FT-IR, XRD, EDX, VSM and FE-SEM. Furthermore, the prepared nanocomposite was applied as a highly effective, heterogeneous and recyclable catalyst for multicomponent synthesis of spirooxindole derivatives as target heterocyclic compounds. Additionally, the current research was shown unique advantages such as; simple synthesis of the catalyst, remarkable magnetic properties, convenient separation of the catalyst using a permanent magnet and the application of cheap and available precursors. At the end of the reaction, it was gained the high yields of products at short reaction times. This indicates the strong catalytic performance of the catalyst that was prepared.
RETRACTED: Quanano ALU: Pioneering Quantum-inspired Computing Paradigms
Authors: Krishna Y. Charan
Published: April 2024

The authors have requested that this preprint be removed from Research Square.
EFFECTS OF TEA (CAMELLIA SINENSIS) CULTIVATION ON SOIL QUALITY IN THE LAM DONG, VIETNAM
Authors:   https://orcid.org/0009-0008-7250-6920, Anh Khoi PhD. Tao
Published: April 2024

The objectives of the study were to assess soil quality and its relationship to the sustainability of tea cultivation in the Lam Dong, Vietnam. Overall soil quality declined with increasing age of the tea plantations as evidenced by decreases in soil OC, total N, K and S, available P and K, mean weight diameter of aggregates. As well, total P, bulk density and mechanical resistance increased with increasing cultivation intensity. Because these soil properties were sensitive to cultivation effects, they were considered to be good indicators of soil quality. Soil properties that were less sensitive to change, and limited as soil quality indicators included texture, clay mineralogy and sesquioxides, and effective cation exchange capacity. Soil quality changes were greatest during the first 10 years of cultivation and were generally greatest in the surface 0- to 40-cm of soil. Soil and crop management factors were considered to be the most important factors affecting soil quality. Decreases in long-term crop yields were found to correspond with decreases in soil quality. In terms of crop productivity, the most important soil quality indicators (based on a multiple regression analysis) were OC, available P, total K and PAWC. Economic analysis of the yield and production cost data indicated that, under current conditions, tea cultivation in the Lam Dong province is sustainable for periods of about 20 years. Thus, measured values of soil quality indicators in the 20-yr tea soils were considered to represent the "critical levels" for economic sustainability of tea cultivation.
UNVEILING THE INVISIBLE:EXAMINING THE LEGAL COMPLEXITY AND SOCIAL SECURITY BENEFITS OF GIG WORKERS
Authors: Rajkumar Chaudhary Subhashchandra , Prajapati Pradeep
Published: April 2024

Gig economy has seen dramatic increase in the workforce participation due to Digital Revolution, Excess Labour supply, Outbreak of Pandemic 2020. However, Gig workers are struggling for social security benefits(Health Benefits, Pension Plans, Maternity Leaves, Accidental Plans, Insurance, Leave Payment, Accidental benefits), that is essential for just and equitable society that governed by regulatory bodies through statutes. However, Unorganized economy in general and particularly Gig workers aredenied to have economic protection due to their legal Status. Prior to Code on Social Security 2020 gig workers are considered as sharing partners and Firms are not obliged to provides economic benefits to sharing partners. Despite having potential,Gig workers have no social security due to the legal complexity of their status as compared to traditional workers. This paper is an attempt to examine the legal taxonomy and analysis of social security issues and to understand the potential and reach of gig workers in the economy. Objective: 1. To examine the legal Status of Gig workers in India. 2. To Understand the social security issues of gig workers. 3. To understand the potential and reach of gig workers in the economy. Hypothesis: 1. The legal status of traditional and Gig workers is the same. 2. There is no significant difference in social security available to traditional and Gig Workers 3. There is no impact of the Gig economy on the Nations Economy. Research Methodology: This research paper is solely based on secondary research from various published and unpublished sources like Magazines, Websites, Newspapers, and Government and non-government organizations.
TUMEUR FRONTIERE GEANTE DE TYPE MUCINEUX ENDOCERVICAL DE LOVAIRE
Authors:   Servicede Gynecologie-Obstetrique, Centre HospitalierUniversitaire MohamedVIdeTanger, Facultede Medecine et Pharmacie de Tanger, Universite Abdel Malek Essaadi, Maroc., Zrigui A. , Akkati M.El ,   Servicede Gynecologie-Obstetrique, Centre HospitalierUniversitaire MohamedVIdeTanger, Facultede Medecine et Pharmacie de Tanger, Universite Abdel Malek Essaadi, Maroc., Hilali F.EL ,   Servicede Gynecologie-Obstetrique, Centre HospitalierUniversitaire MohamedVIdeTanger, Facultede Medecine et Pharmacie de Tanger, Universite Abdel Malek Essaadi, Maroc., Moustaide H. ,   Servicede Gynecologie-Obstetrique, Centre HospitalierUniversitaire MohamedVIdeTanger, Facultede Medecine et Pharmacie de Tanger, Universite Abdel Malek Essaadi, Maroc., Benkirane S. ,   Servicede Gynecologie-Obstetrique, Centre HospitalierUniversitaire MohamedVIdeTanger, Facultede Medecine et Pharmacie de Tanger, Universite Abdel Malek Essaadi, Maroc.
Published: April 2024

Les tumeurs frontieres de lovaire, sont des tumeurs a la limite de la malignite representant 5a 20 % des tumeurs epitheliales de lovaire, et survenant rarement chez les femmes menopausees.Leur pronostic est meilleur que celui des lesions invasives. Le diagnostic est oriente par la clinique et limagerie.Lechoix de traitementchirurgicalradical ou conservateur depend de plusieurs facteurs et caracteristiques radio-cliniques. Lhistologie confirme le diagnostic et le traitement adjuvant est generalement indique dans les stades avances de ces tumeurs. Dans notre article, nous rapportons un cas particulierdunetumeur frontiere ovarienne de type mucineux endocervical geante chez une femmede 56ans et menopausee, a travers lequel nous mettons le doigt sur la particularite de cette rare forme des tumeurs qui ne se voit pas habituellementapres la menopause et qui pose un dilemme diagnostique et therapeutique. Le but de notre travail est dattirerlattention des praticiens sur cette pathologie et eclairer les differentes options diagnostic et therapeutique.
IPSILATERAL NON-UNION FRACTURE NECK AND SHAFT OF FEMUR WITH BROKEN IMPLANT IN SITU TREATED BY ORTHO-FIX LIMB RECONSTRUCTION SYSTEM AND EXTERNAL FIXATOR WITHOUT BONE GRAFTING OR CORTICOTOMY: A CASE REPORT
Authors: Saxena Vikas , Shahid Raza Muhammad , Panwar Akshay , Akshay Varun
Published: April 2024

Non-union is a well-known complication of fractures of the femoral neck. The concurrence of non-union of the femoral shaft and the femoral neck is a rare combination that will cause significant challanges during surgery. There are controversies in the literature regarding fracture fixation techniques, such as intramedullary versus extramedullary implants and single versus double implants for both fractures, especially in youthful patients. We discuss our experience in treating a juvenile patient with non-union fracture neck of femur and ipsilateral femoral shaft, and a broken implant in situ.Orthofix limb reconstruction system (LRS) is utilised for non-union fracture shaft of femur, while fracture neck of femur is provisionally stabilised by external fixator. The radiological union of the femoral neck occurred at 6 weeks and the femoral shaft at 7 months. At 9 months, the LRS was removed, and at 10 months, the patient had nearly full hip and knee range of motion. Orthofix LRS is a viable option for the treatment of ipsilateral non-union fractures of the shaft and neck of the femur, especially when infection is present or suspected.
A CASE REPORT ON JUVENILE XANTHOGRANULOMA
Authors:   Assistant Professor, Department of Pathology, Mahatma Gandhi Medical College, Jaipur, Rajasthan, 302022, India., Rathod Himaxi
Published: April 2024

Introduction: Juvenile Xanthogranuloma is a rare, benign, asymptomatic and commonly self-healing histiocytic disorder. It is a type of Non-Langerhans cell histiocytosis affecting primarily first two decades of life as a solitary cutaneous lesion occurring most frequently on trunk and upper extremities. There can also be involved internal organs such as lungs, kidney, gastrointestinal tract etc. Most common extracutaneous location is eye. Case presentation: Here presenting case of 5 month old male child with complain of firm, mobile, non-tender swelling just proximal to the left wrist joint since 4 months. Conclusion: Cytomorphological diagnosis of benign fibrohistiocytic lesion with possibility of Juvenile Xanthogranuloma was made & later confirmed by histological examination.
PSYCHIATRIC MORBIDITY AND MARITAL SATISFACTION IN SPOUSES OF PATIENTS WITH ALCOHOL DEPENDENCE SYNDROME
Authors:   Assistant Professor, Department of Psychiatry MGM Medical College and Hospital, Aurangabad., P. Murambikar Gaurav , Gupta Riya ,   Senior Resident, Department of Psychiatry L.N. Medical College and J.K. Hospital, Bhopal., Gupta Prince ,   Consultant Psychiatrist, Sukhkarta Psychiatric and Neuro Care Shakuntalam Hospital, Ghajjar, Haryana., V. Marwale Arun ,   Professor Department of Psychiatry MGM, Medical College and Hospital, Aurangabad.
Published: April 2024

Background: Prevalence of alcohol dependence in men has been increasing worldwide, particularly in India. Alcohol dependence syndrome appears to be associated with psychiatric problems specially among spouses. Understanding and addressing the effects of such psychiatric problems becomes necessary. Aim: The aim of this study was to assess the pattern of psychiatric morbidity and marital satisfaction in spouses of patients with alcohol dependence syndrome. Materials and Methods: 246 men with alcohol dependence syndrome and their spouses were evaluated. Marital satisfaction was assessed using the ENRICH marital satisfaction scale. Mini International Neuropsychiatric Interviews (MINI) was used to screen for the possible presence of psychiatric morbidity among spouses. Severity of alcohol dependence in the husbands and consequences of drinking was assessed using Short Alcohol Dependence Data (SADD) and drinkers inventory of consequences (DrInC) respectively. Results: More than half of the spouses (57.72%) had a psychiatric disorder. Primarily mood and anxiety disorder were present. Major depressive disorder was present in 33.33%. Psychiatric morbidity among spouses was significantly associated with SADD. Significant association was found between age, education status, occupation, religion and psychiatric morbidity of spouses. Marital satisfaction score was low and conflicts between the couple was significantly associated with psychiatric morbidity of spouses. Conclusion: Psychiatric morbidity in spouses of alcohol dependent men is high, with marital satisfaction being low. Addressing these issues in spouses can improve their quality of life as they play an important role in the treatment of alcohol dependence syndrome.
PITUITARY STONE ADENOMA ASSOCIATED WITH SEVERE HYPERPROLACTINEMIA CASE REPORT
Authors:   Endocrinology and Diabetology Department, Mohammed V Military Academic Hospital, Faculty of Medicine and Pharmacy, Mohammed V- UniversitySouissi, Rabat, Morocco., Ahmed Anas Guerboub , Mostarchid Mamoune El ,   Neurosurgery Department, Mohammed V Military Academic Hospital, Faculty of Medicine and Pharmacy, Mohammed V- UniversitySouissi, Rabat, Morocco., Jade Issouani ,   Endocrinology and Diabetology Department, Mohammed V Military Academic Hospital, Faculty of Medicine and Pharmacy, Mohammed V- UniversitySouissi, Rabat, Morocco., Miloudi Gazzaz ,   Neurosurgery Department, Mohammed V Military Academic Hospital, Faculty of Medicine and Pharmacy, Mohammed V- UniversitySouissi, Rabat, Morocco., Mostarchid Brahim El ,   Neurosurgery Department, Mohammed V Military Academic Hospital, Faculty of Medicine and Pharmacy, Mohammed V- UniversitySouissi, Rabat, Morocco., Yassine Errahali ,   Endocrinology and Diabetology Department, Mohammed V Military Academic Hospital, Faculty of Medicine and Pharmacy, Mohammed V- UniversitySouissi, Rabat, Morocco.
Published: April 2024

A 35-year-old patient consulting for erectile dysfunction, with a progressive visual acuity loss. Biological assessment revealed hyperprolactinemia at 4315 ng/ml and low testosteronemia at 6.8 nmol/l. Skull X-ray showed an enlarged sellaturcica with voluminous intra- and suprasellar calcifications. A cranial CT scan revealed an intra- and suprasellar calcified mass. Transphenoidal surgery was performed. The tumor was partially removed and the piece was made of calcified grayish granular tissue. Histological examination showed adenomatous cells with large granular calcification lesions. Immunohistochemistry confirmed prolactin adenoma. Cabergoline treatment was effective on the calcified tissue remaining after surgery.
ESTROGEN LOWERS HEART RATE IN PRE-OVULATORY PHASE OF MENSTRUAL CYCLE IN WOMEN
Authors:   Endocrinology Laboratory, Department of Zoology, University of Kalyani, Kalyani-741235, Nadia, West Bengal, India., Biswas Maharaj , Ghosh Anirban ,   Department of General Medicine, College of Medicine and Jawaharlal Neheru Hospital, The West Bengal University of Health Sciences, Kalyani-741235, Nadia, West Bengal, India.
Published: April 2024

Hormonal fluctuation in various phases of menstrual cycle may be an important regulatory factor of heart rate. Based on this proposition, an observational study was conducted in 81 women with normal reproductive health to find out the changes of heart rate in the pre-ovulatory (10-13th day of menstrual cycle) and post-ovulatory phases of menstrual cycle. Data were analyzed using Pearson correlation and paired t-test. The test for correlation coefficient using t-statistics showed that the changes of heart rate between pre-ovulatory and post-ovulatory phases was statistically significant (r= 0.79, R2=0.63 and p<0.01). On the other hand, the paired t-test (2 tails) revealed that the heart rate was significantly decreased (t= 3.86, df=80, Md=3.04 and p<0.01) in the pre-ovulatory phase when compared to the post-ovulatory phase. It is well documented that both estrogen and progesterone level are found to have moderate in luteal phase in relation to the pre-ovulatory phase during LH surge or peak estrogen level and it is approximately 10 times just 10-12 hours before ovulation. From the endocrinological view point, it can be concluded that the estrogen may have the heart rate lowering effects in pre-ovulatory phase in the study subjects.
A PROPOSAL FOR AN INNOVATIVE APPROACH TO EXTENDED MODELLING CYCLES INCORPORATING PROBLEM-POSING FROM A CREATIVITY PERSPECTIVE
Authors:   Ogaki Womans College, Nishinokawacho 1-109, Ogaki, 503-8554, Japan., Okamoto Hidemichi
Published: April 2024

Many studies have shown that mathematical modelling, creativity, and problem-posing activities are deeply related. However, there is a lack of research that poses mathematical modelling problems. Additionally,only few studies have conducted statistical analyses of the relationship between creativity in problem-posing and creativity in psychology. The purpose of this research is to conduct a survey to quantitatively evaluate creativity, and to propose a more effective modelling cycle based on the survey results. This study focuses on fluency a creativity factor that is measured by the number of problems posed by students. The survey results showed a moderate positive correlation between fluency in posing mathematical modelling problems and creativity in psychology (r = 0.44, p <0.01). Based on the results, an extended modelling cycle is proposed and discussed.
EFFECTIVENESS OF STRUCTURED TEACHING PROGRAM ON KNOWLEDGE REGARDING CYBERBULLYING AMONG 3RD YEAR B.SC. NURSING STUDENTS
Authors:   Principal, SCPM College of Nursing and Paramedical Sciences, Gonda., M. Manimegalai , Singh Ajeet ,   B.Sc. Nursing 4th Year Students., Dubey Anamika ,   B.Sc. Nursing 4th Year Students., a Aastha ,   B.Sc. Nursing 4th Year Students., Arya Richa ,   B.Sc. Nursing 4th Year Students.
Published: April 2024

Background of the study: This present study was done under the topic A study to assess the effectiveness of structured teaching program on knowledge regarding Cyberbullying among 3nd year B.Sc. Nursing students studying at SCPM College of nursing and paramedical sciences, Gonda. Methods: A Pre-experimental one group pretest posttest design was adopted for this study. 30 B.Sc. nursing students were selected as samples using Non probability purposive sampling technique. Socio demographic variables, Structured knowledge questionnaire were used as tools to assess the knowledge. Results: In pretest, 80.0% of the samples had inadequate knowledge score, 20.00% of them had moderate level of knowledge score and none of them had adequate knowledge score regarding Cyber bullying. Whereas in posttest, none of them had inadequate level knowledge score, 26.67% of them had moderate level of knowledge score and 73.33% of them are had adequate level of knowledge score regarding Cyber bullying. Statistically there was a significant difference between pretest and post-test knowledge score regarding cyber-bullying at the level of P< 0.001. Conclusion: This study concluded that structured teaching program was found to be an effective teaching strategy in improving knowledge of nursing students regarding cyber bullying.
TRANSFORMATIONAL LEADERSHIP AND EMPLOYEE CREATIVITY: AN EMPIRICAL STUDY
Authors:   Department of Commerce, School of Business Studies, University of Kashmir, Srinagar, J&K, India., Bashir Sameeul , Ahmad Nazir Nazir ,   Department of Commerce, School of Business Studies, University of Kashmir, Srinagar, J&K, India.
Published: April 2024

Whether or not transformational leadership antecedes employee creativity is explored in this research endeavour. Sample respondents from 3-5-star hotels self-reported their creativity in addition to reporting the transformational leadership style of their leaders. Transformational leadership along with its four dimensions was associated with the creative behaviour of an employee. The study found a positive and significant association between transformational leadership style and employee creativity. However, the variances in the association between the sub-factors of TL and EC further elucidate the relationship between TL and EC. We discuss the findings about transformational leadership style and employee creativity.
A RARE CASE OF LARGE SIZE UNDIFFERENTIATED PLEOMORPHIC SARCOMA OF ANKLE
Authors:   Post Graduate, Department OG General Surgery Siddhartha Medical College, Vijayawada, Andhra Pradesh., Karthik Naik Deeravathu , Kalyani Adiraju ,   Assosciate Professor, Department OG General Surgery Siddhartha Medical College, Vijayawada, Andhra Pradesh.
Published: April 2024

Undifferentiated sarcoma shows no identifiable line of differentiationwhen analyzed by presently available technology (WHO 5th edition). Occurs as 20% of all soft tissue sarcomas.tumor most frequently occurs in soft tissues of extremeties and retroperitoneum .Peaks around age of 60 years .More common in men.It begins as a painless enlarging mass ,generally in relation to skeletal muscle,deep fascia or subcutaneous tissue.MRI is the investigation of choice for all soft tissue sarcomas.Prognosis include depth of tumor and staging of tumor .Surgerical resection of tumor fallowed by radiotherapy is main stay of treatment.
Factors affecting consumer intentions and actual behavior: A case of food delivery applications
Authors: Tri Cuong Dam
Published: April 2024

Customers and food vendors communicate directly through mobile devices. Consumers easily purchase pre-prepared meals via food delivery applications, no matter where they are, even at the convenience of their residences. Therefore, this paper aims to analyze the determinants that affect customers’ propensity to purchase and their actual behavior in the setting of food delivery applications. The impact that subjective norms have on consumers’ attitudes toward food ordering via food delivery applications is also examined. The theory of reasoned action and prospect theory are the two basic theories that this study draws on. A convenience sample approach was used to gather data from 288 consumers in Vietnam who placed meal orders using food delivery applications. The data collection was conducted using Google Forms. The results indicated that consumers’ attitude toward purchasing food via food delivery applications positively influenced their buying propensity (β = 0.191, p = 0.001). Similarly, the findings also highlighted that consumers’ subjective norm positively affected both their attitude (β = 0.417, p = 0.000) and their inclination to purchase (β = 0.258, p = 0.000). Likewise, discount framing emerged as the most influential factor affecting purchase intentions (β = 0.262, p = 0.000). Furthermore, customers’ intentions significantly contributed to their actual behavior in acquiring pre-prepared meals through food delivery applications (β = 0.556, p = 0.000). Ultimately, the study offered suggestions for executives, identified limits, and proposed avenues for future research.
AcknowledgmentThe author acknowledges Industrial University of Ho Chi Minh City that supported this study.
Impact of attention on rare events across industries in Indonesia
Authors: Hariyanto Dedi , Khresna Brahmana Rayenda , Wendy Wendy
Published: April 2024

Rare events (RE) are substantial with significant impact but are difficult to predict, often deviating from regular expectations. These events trigger psychological reactions in the market and susceptible to irrational decisions that challenge logical assumptions. The rapidity of the crisis has led to highly volatile market conditions, fostering instances of asymmetric information. Therefore, this study aimed to explore the impact of attention on market dynamics by examining diverse possibilities over time. The article focused on all publicly listed industries on the Indonesian Stock Exchange (IDX/BEI). Using time series regression data from 1997 to 2020, the article comprised 5,615 observations across nine sectors. The primary model was based on three factors originating from the Fama-French and prospect theory, with attention serving as the main risk element to assess the impact of attention on abnormal returns (AR) during RE. The results disclosed that various events showed diverse effects on attention behavior, varying across all sectors. Additionally, moderation analysis showed a correlation between attention and AR. The results signified that RE mitigates the negative relationship between attention and AR. The adverse impact of attention on AR diminishes during RE. These results contributed to the literature by providing insights into the excessive attention to specific information disrupts market mechanisms, triggers disproportionate emotional responses, and alters investor preferences. Furthermore, this study established that events prompting excessive attention have varying effects on attention behavior across all sectors.
Emerging contaminants in municipal sewage/sludge: occurrence, risk assessment, and treatment technologies
Authors: Wang Bing , Jiang Tao , Wang Nana , Zou Qianqian
Published: April 2024

Emerging contaminants (ECs) have received widespread attention globally due to their potential ecological and human health impacts. Sludge, a byproduct of the sewage treatment processes, accumulates amounts of ECs or toxic byproducts that have not been fully degraded. Without proper treatment, it may affect the resource utilization of sludge and damage the ecological environment. Therefore, it is significant to investigate the generation mechanism of ECs in municipal sewage/sludge and explore effective treatment technologies to remove them. This chapter first reviews the main occurrence of ECs in municipal sewage/sludge. Secondly, the potential environmental risks of ECs are evaluated, and the treatment technologies of different ECs are discussed in detail, such as anaerobic consumption, aerobic composting, and advanced oxidation. Finally, suggestions and prospects are put forward for the removal of ECs from municipal sewage/sludge.
A brief account of the antibiotics and antibiotic resistance genes in an aquatic environment
Authors: Yadav Nikita , Mandpe Ashootosh , Shukla Sudeep
Published: April 2024

Inappropriate disposal of pharmaceutical waste containing antibiotics into water bodies developed the catastrophe of antibiotic resistance. The occurrence and, thereafter, bioaccumulation of antibiotics in the aquatic ecosystem have raised concern about their associated toxicity toward aquatic organisms. Their presence in aquatic bodies has been widely discussed in developed nations. However, in many developing countries like India, minimal research has been reported on the status of antibiotics in the aquatic environment. This chapter summarizes the global distribution of antibiotics in the aquatic environment, their effects on the microbial community, the evaluation and assessment of antibiotic risks, and the source tracking of these emerging pollutants. Another key objective of this chapter is to investigate the trends in consumption, distribution, and fate of major antibiotic classes in India and their dynamic relation to the biotic world. The eco-toxicity of these emerging contaminants towards different flora and fauna communities at different trophic levels with targeted assessment and remediation technologies, including percent removal efficiencies, has been discussed. Legislative and regulatory measures carried out for the effective management of this growing epidemic by various governments have also been discussed.
A novel machine learning-based framework for the water quality parameters prediction using hybrid long short-term memory and locally weighted scatterplot smoothing methods
Authors: Dodig Ana , Ricci Elisa , Kvascev Goran , Stojkovic Milan
Published: April 2024

Water quality prediction is crucial for effective river stream management. Dissolved oxygen, conductivity and chemical oxygen demand are vital chemical parameters for water quality. Development of machine learning (ML) and deep learning (DL) methods made them widely used in this domain. Sophisticated DL techniques, especially long short-term memory (LSTM) networks, are required for accurate, real-time multistep prediction. LSTM networks are effective in predicting water quality due to their ability to handle long-term dependencies in sequential data. We propose a novel hybrid approach for water quality parameters prediction combining DL with data smoothing method. The Sava river at the Jamena hydrological station serves as a case study. Our workflow uses LSTM networks alongside LOcally WEighted Scatterplot Smoothing (LOWESS) technique for data filtering. For comparison, Support Vector Regressor (SVR) is used as the baseline method. Performance is evaluated using Root Mean Squared Error (RMSE) and Coefficient of Determination R2 metrics. Results demonstrate that LSTM outperforms the baseline method, with an R2 up to 0.9998 and RMSE of 0.0230 on the test set for dissolved oxygen. Over a 5-day prediction period, our approach achieves R2 of 0.9912 and RMSE of 0.1610 confirming it as a reliable method for water quality multistep parameters prediction.
30th EACTS Annual Meeting 2016
Authors: Semenjuta D.
Published: April 2024

In Russ.
A leader must take charge of everything
Authors: Meshalkin E.
Published: April 2024

An interview with Evgeny N. Meshalkin “A leader must take charge of everything” was published in the first Patologiya krovoobrashcheniya i kardiokhirurgiya issue in 1997 (Patologiya krovoobrashcheniya i kardiokhirurgiya;1997(1):14-16). The paper has been reproduced exactly as it originally appeared.
THE EFFECT OF COVİD 19 FEAR ON MATERNAL ATTACHMENT IN THE POSTPARTUM PERIOD
Authors: Çıtak Gizem , Alparslan Özgür , Işık Selin
Published: April 2024

Objective: This study was conducted to determine the effects of COVID-19 fear experienced by mothers during the pandemic on maternal attachment.
Materials and Method: This descriptive and cross-sectional study was conducted between 15.03.2022-15.04.2022 with 170 puerperium hospitalized in the obstetrics and gynecology department of a state hospital. Data were collected using the Personal Information Form, COVID-19 Fear Scale and Maternal Attachment Scale (MATS) created by the researchers.
Findings: Among the puerperas included in the study, 62.4% were between 26-35 years of age, 51.8% were high school graduates, 68.8% were unemployed, and 47.6% lived on minimum wage. According to multivariate linear regression analysis, it was found that the total score of the MBS affected age, occupation, income status and social security status and was a significant predictor of fear of COVID-19 (p
Apresentação: Dossiê Corpos, Gêneros e Sexualidades: tensionamentos e provocações para a educação
Authors: Silva Elenita Queiroz Pinheiro , Costa Ribeiro Paula Regina
Published: April 2024

O Dossiê Corpos, gêneros e sexualidades: tensionamentos e provocações a educação compõem um espaço de muitas vozes, sons, sensações, movimentos. Elas revelam e desmontam as tensões e as disputas em torno de corpos, gêneros e sexualidades, na/para a educação. Especialmente aquelas mobilizadas nos últimos anos, de forma mais contundente, quando dos ruídos gerados pela intensificação da onda da ofensiva antigênero em nosso país e em outras partes do mundo. Reunir e convocar vozes, sons, sensações e movimentos de pesquisadoras e pesquisadores que desnudam as políticas e produções de gênero e sexualidade interseccionadas com classe, raça, regionalidade, religiosidade e geração, marca a intenção de composição de leituras e análises dos diversos e intensos processos de subalternização, silenciamento e apagamento de determinados grupamentos – LGBTQIA+, negros e negras, povos originários, pessoas empobrecidas..
Bringing the Public Health Informatics and Technology Workforce Together: The PHIAT Conference
Authors: Moreno Arellano April , Shih Huan-ju , Williams Karmen S
Published: April 2024

The field of public health informatics has undergone significant evolution in recent years, and advancements in technology and its applications are imperative to address emerging public health challenges. Interdisciplinary approaches and training can assist with these challenges. In 2023, the inaugural Public Health Informatics and Technology (PHIAT) Conference was established as a hybrid 3-day conference at the University of California, San Diego, and online. The conference’s goal was to establish a forum for academics and public health organizations to discuss and tackle new opportunities and challenges in public health informatics and technology. This paper provides an overview of the quest for interest, speakers and topics, evaluations from the attendees, and lessons learned to be implemented in future conferences.
Exploring the Digital Health Divide and Determinants among Urban and Rural Elderly in China: Empirical Evidence Based on Capital Theory (Preprint)
Authors: Yang Yanbin , Ma Chengyu , Liu Haopeng , Lv Siyu , Liao Weizhen
Published: April 2024

BACKGROUND

The aging population in China is becoming increasingly severe, and there is a health inequality phenomenon among urban and rural elderly. With the development of ICT, eHealth has become one of the important factors affecting health. Urban elderly could more conveniently access health information and medical services, while rural elderly may have difficulty enjoying the digital dividends brought by eHealth, highlighting the phenomenon of the “digital health divide”.

OBJECTIVE

This study analyzes the digital health divide and determinants among urban and rural elderly from the perspective of capital theory.

METHODS

The model for analyzing the digital health divide among urban and rural elderly is constructed based on capital theory. Analysis of variance is used to verify the digital health divide among urban and rural elderly. Structural equation modeling is used to analyze the factors, and the Blinder-Oaxaca decomposition method is used to analyze the main causes.

RESULTS

There are three levels of digital health divide among urban and rural elderly, namely digital access divide (F=11.39, P<.01), digital usage divide (F=39.53, P<.001), and digital outcome divide (F=30.20, P<.001). The influence of different levels of divide is transmitted along the digital chain, the impact coefficient of digital access divide on digital usage divide is β=0.060 (P<.05), and digital usage divide on digital outcome divide is β=0.363 (P<.001). The digital usage divide is the most significant level, and cultural capital (β=0.221, P<.001), social support (β=0.361, P<.001), economic capital (β=0.111, P<.01), and habits (β=0.248, P<.001) are most dominant factors contributing to the rural-urban digital usage divide. The Blinder-Oaxaca decomposition results further indicate that cultural capital (33.9%) and social capital (22.5%) are the main factors influencing digital usage divide among urban and rural elderly.

CONCLUSIONS

here exists digital health divide among urban and rural elderly, and the influence of three level of divide is transmitted along the digital chain. The digital usage divide is the main level, cultural capital and social capital are the main reasons for its formation. To against these divides among urban and rural elderly, interventions in policy, society, technology, and economics are recommended.
Effect of active music therapy conducted by medical professionals on reducing agitation in patients with dementia: A systematic review and meta-analysis (Preprint)
Authors: Huang Jian-Jia , Chung Yun-Chen , Chung Yun-Chen , Pei Yu-Cheng
Published: April 2024

BACKGROUND

Music therapy (MT) has been suggested to be effective at reducing agitation in patients with dementia. However, some randomized controlled trials (RCTs) and high-quality reviews have indicated that MT might not be effective at reducing agitation. In addition, the efficacy of MT might differ among methods and professionals, an important question that has not been adequately addressed.

OBJECTIVE

To evaluate the effects of MT on agitation in patients with dementia compared with those of general therapy (GT).

METHODS

RCTs evaluating the efficacy of MTs in reducing agitation in patients with dementia were identified from MEDLINE, PubMed, and the Cochrane Library. The primary outcome was reduced agitation estimated by the alternation of standard assessments in MT and GT; a subgroup analysis compared the effectiveness of different MT methods, the intensity of treatment, and the severity of agitation. All outcomes were measured using standard assessment tools. The heterogeneity of the studies was examined. The quality of the studies and risk of bias were assessed. The effects were pooled by performing a meta-analysis.

RESULTS

Nine RCTs involving 507 participants with dementia were included. No significant differences in agitation were found between participants receiving MT or those receiving GT. According to the subgroup analysis, no significant differences in music therapy performed by music therapists vs. other medical professionals, conducted in group therapy vs. individual therapy, conducted with prescribed music vs. using individualized music, applied in institutes vs. communities, conducted with interventions < 2 times a week vs. interventions ≥ 2 times a week, or among patients with mild to moderate dementia vs. severe dementia were observed.

CONCLUSIONS

The present meta-analysis indicated that MT is not significantly effective at reducing agitation compared with GT in patients with dementia. More high-quality RCTs are needed to ascertain the effect of MT on dementia.
A Comparative Legal Research for Patient-Generated Health Data in the United States, Australia, and South Korea (Preprint)
Authors: Lee Yura , Beck Sang Sook , Park Ye-Eun , Lee Jae-Ho
Published: April 2024

BACKGROUND

The healthcare service paradigm is shifting towards patient-centered care, which necessitates integrating patient-generated health data (PGHD) with electronic health records (EHRs) to provide a comprehensive understanding of their health. This integration faces legal and technical challenges when connecting and utilizing PGHD in medical institutions. As digital health technologies advance, the legal landscape surrounding PGHD regulation becomes increasingly complex, highlighting the need for comparative legal research to analyze and compare the legal frameworks governing it.

OBJECTIVE

This comparative legal research aims to analyze and compare the legal frameworks governing PGHD in the United States, Australia, and South Korea. Employing a functional approach, the study seeks to identify key legal issues, including the right to data portability, exceptions to information blocking, interoperability, user authentication, and non-legal instruments in research ethics. The objective is to provide insights into the legal landscape surrounding PGHD and highlight areas for improvement and harmonization.

METHODS

The study conducted a comprehensive review of legal documents, including statutes, regulations, and academic articles, as well as reports from government agencies and non-governmental organizations. Data collection and analysis were conducted to identify similarities and differences in the legal frameworks across the three countries.

RESULTS

The study explored key legal issues such as the right to data portability, exceptions to information blocking, interoperability, user authentication, and non-legal instruments in research ethics. It observed variations in implementing the right to data portability, with South Korea recently introducing relevant provisions. Countries varied in their interoperability strategies, addressing challenges in data exchange. Concerns about user authentication prompted measures such as healthcare identifiers. Non-legal instruments, including soft norms and codes of conduct, complemented legal frameworks, providing additional privacy protection in research. Challenges include ensuring PGHD's trustworthiness and encouraging healthcare provider participation.

CONCLUSIONS

The study underscores the necessity of regulations tailored to each country's healthcare system, prioritizing patient rights, data quality, interoperability, and information protection in the evolving digital healthcare landscape.
Feasibility of a Mobile App–Based Cognitive-Behavioral Perinatal Skills Program: Protocol for Nonrandomized Pilot Trial (Preprint)
Authors: Temkin-Yu Andrea B , Ayaz Aliza , Blicker Ella , Liu Michael X , Oh Ace , Siegel Isabelle E , Seewald Meredith J , Hermann Alison D , Givrad Soudebah , Baez Lara M , Osborne Lauren M , Green Cori M , Schier Maddy M , Davis Alexandra M , Zhu Shasha , Falk Avital , Bennett Shannon M
Published: April 2024

BACKGROUND

Mental illness is one of the top causes of preventable pregnancy-related deaths in the United States. There are many barriers that interfere with the ability of perinatal individuals to access traditional mental health care. Digital health interventions, including app-based programs, have the potential to increase access to useful tools for these individuals. Although numerous mental health apps exist, there is little research on developing programs to address the unique needs of perinatal individuals. In an effort to fill this gap, a multidisciplinary team of experts in psychology, psychiatry, obstetrics, and pediatric primary care collaborated to develop the novel Perinatal Skills Program within Maya, a flexible and customizable cognitive-behavioral skills app. Maya-Perinatal Skills Program (M-PSP) uses evidence-based strategies to help individuals manage their mood and anxiety symptoms during pregnancy and post partum.

OBJECTIVE

This pilot study aims to assess the feasibility, acceptability, and usability of M-PSP and explore links between program use and symptoms of anxiety and low mood.

METHODS

This single-arm trial will recruit 50 pregnant or postpartum individuals with mild-to-moderate anxiety or mood symptoms. Participants will be recruited from a variety of public and private insurance-based psychiatry, obstetrics, and primary care clinics at a large academic medical center located in New York City. Participants will complete all sessions of M-PSP and provide feedback. Outcome measures will include qualitative and quantitative assessments of feasibility, acceptability, and usability, passively collected program usage data, and symptom measures assessing mood, anxiety, and trauma. Planned data analysis includes the use of the grounded theory approach to identify common themes in qualitative feedback, as well as an exploration of possible associations between quantitative data regarding program use and symptoms.

RESULTS

The recruitment began on August 2023. As of October 2024, a total of 32 participants have been enrolled. The recruitment will continue until 50 participants have been enrolled.

CONCLUSIONS

Digital health interventions, like M-PSP, have the potential to create new pathways to reach individuals struggling with their mental health. The results of this study will be the groundwork for future iterations of M-PSP in the hopes of providing an accessible and helpful tool for pregnant and postpartum individuals.

CLINICALTRIAL

ClinicalTrials.gov NCT05897619; https://classic.clinicaltrials.gov/ct2/show/NCT05897619

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/59461
An evaluation on community participation in ecotourism activities post Covid-19 pandemic at Tan Loc islet, Thot Not district, Can Tho city
Authors: Nguyen Thi Huynh Phuong , Thai Cong Dan , Le Viet Nghia , Nguyen Thi Be Ba , Ly My Tien , Le Thi To Quyen
Published: April 2024

The article aims to assess the status of community participation and the factors affecting community participation in ecotourism activities at Tan Loc islet, Thot Not district, Can Tho City after the Covid-19 pandemic. This study is conducted through documents, field trips, and questionnaires. The empirical results show five factors affecting community participation: perception of economic benefits, social capital, local resources, local policies, and lessons from the Covid-19 pandemic. Based on those mentioned earlier, the paper proposes several solutions to enhance community participation in ecotourism development in this area.
Sovereign risk and Financial Stability. Evidence from Eurozone Countries
Authors: Marinescu Ada Cristina
Published: April 2024

We will investigate in this paper the relationship between sovereign risk and domestic banks' exposure to the government debt, using data for eurozone countries. The sovereign-bank nexus shows that there are substantial influences between the fiscal and the financial sector and that in absence of enough fiscal buffers, the rise in public borrowing will contribute to financial market imbalances, through various channels. We apply impulse-response functions in order to investigate the effect of a shock produced to sovereign risk to banks' exposure to government debt. Our results confirm that there are significant interlinkages between sustainable fiscal positions and financial markets performance, so that reducing debt levels can contribute to decreasing sovereign risk premia and improvement in financial conditions, decreasing the exposure of the banking sector to holding large shares of debt, which can result in deteriorating economic conditions.
Research on the Path of High-Quality Development of Internal Audit in Real Estate Industry
Authors: Lv Baofeng
Published: April 2024

The internal audit of real estate enterprises is a very important part of the business activities of enterprises, is an important means to effectively control the internal management risk of enterprises, improve the efficiency of operation and management, and reduce costs. High-quality internal audit plays a very important role in the development and growth of enterprises. Based on the present situation of the internal audit of real estate industry, this paper analyzes the problems existing in the internal audit of real estate enterprises, and puts forward the corresponding improvement measures.