bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing a construct to measure contractor project manager performance competencies
Authors: Kassa Rebecca , Ogundare Ibilola , Lines Brian , Smithwick Jake B. , Kepple Nancy J. , Sullivan Kenneth T.
Published: November 2023

Purpose

Construction organizations' investment in effective talent-development programs is a key strategy in attracting, developing and retaining staff. Such programs are especially important given the current challenges in the construction workforce, including labor shortages, an aging workforce, generational differences in the workforce, supply chain disruptions and the need to effectively train staff in the skills that are essential in a constrained labor environment. To address these challenges, this study proposes a performance measurement strategy that construction companies can use as input to design their talent development programs.

Design/methodology/approach

The strategy intends to assess the performance of project managers and develop criteria that define categories of their performance, including the top performers' category. This enables construction organizations to provide each project manager with individualized training that addresses areas of weakness and in turn, develops the skills that correspond with being top performers. The proposed strategy was developed and tested by surveying the immediate supervisors of 187 project managers working for general and specialty contractors in the United States. Principal component analysis was used to develop a single performance construct from seven performance criteria.

Findings

This construct was used to organize the project managers into the categories of top, above-average and below-average performers. According to the findings, top-performing project managers have well-rounded skills in the areas of leadership, communication, technical proficiency and overall job knowledge.

Practical implications

The outcomes of this study can help construction organizations focus their talent-development programs on the skills most associated with PMs being top performers.

Originality/value

This study provides construction organizations with a comprehensive performance-measuring construct to focus their talent-development programs on the skills most associated with top-performing project managers. Researchers can use this study as a foundation for further understanding how performance is related to various construction professions.
Task performance and training of employees: the mediating role of employee engagement in the tourism and hospitality industry
Authors: Arwab Mohd , Adil Mohd , Nasir Mohd , Ali Mohd Ashraf
Published: November 2023

Purpose

The purpose of this study is to analyse the perception of employees towards training and also examine the mediation effect of employee engagement between training and task performance.

Design/methodology/approach

An integrated model has been developed highlighting the relationship of the motivation for training and support for training and their implications on task performance through the mediating role of employee engagement. Using the sample of 397, structural equation modelling has been used with the help of SPSS and AMOS to validate the hypothesized relationship and evaluate the responses of employees working in travel agencies operating in Delhi (capital), India.

Findings

The findings of this study demonstrated a positively significant relationship between training and task performance of employees in the tourism and hospitality industry. Simultaneously, employee engagement positively mediates the relationship between training and task performance directly and indirectly. This study goes over the ramifications of the findings and offers some suggestions for practical implementations.

Practical implications

The findings of this study can be used by managers and HR professionals to organize exclusive training programs for improving employees’ performance based on the dimensions used in this study. This study also suggests that training program enhances employee engagement in organizational activities which leads to build up team work and overall organizational as well as individual performance.

Originality/value

This study also introduces a conceptual model and theoretical framework that provide a significant contribution to the training and task performance of employees. This study provides a strong theoretical foundation by incorporating the social exchange theory to confirm the role of employee engagement in performance. Further, this novel piece of research explores the relationship between training and task performance with employee engagement as a mediator, especially in the Indian tourism and hospitality industry.
Exploring the differentiated elderly service subsidies considering consumer word-of-mouth preferences
Authors: Li Keqing , Wang Xiaojia , Liang Changyong , Lu Wenxing
Published: November 2023

Purpose

The elderly service industry is emerging in China. The Chinese government introduced a series of policies to guide elderly service enterprises to improve their service quality. This study explores novel differentiated subsidy strategies that not only promote the improvement of service quality in elderly service enterprises but also alleviate the financial burden on the government.

Design/methodology/approach

Evolutionary game and Hotelling models are employed to investigate this issue. First, a Hotelling model that considers consumer word-of-mouth preferences is established. Subsequently, an evolutionary game model between local governments and enterprises is constructed, and the evolutionary stable strategies of both parties are analyzed. Finally, simulation experiments are conducted.

Findings

The findings indicate that local government decisions have a significant influence on the behavior of elderly service enterprises. Increasing the proportion of local governments opting for subsidy strategies helps incentivize elderly service enterprises to improve their service quality. Furthermore, providing differentiated subsidies based on the preferences of the customer base of elderly service enterprises can encourage service quality improvement while reducing government expenditure. The findings offer valuable insights into the design of government subsidy policies.

Originality/value

Compared with previous research, this study examines the role of consumer preferences in a differentiated subsidy policy. This enriches the authors’ understanding of the field by incorporating neglected aspects of consumer preferences in the context of the emerging elderly service industry.
Are they really better? Employer branding in companies from the employer ranking
Authors: Kucherov Dmitry , Tsybova Victoria
Published: November 2023

Purpose

The purpose of this paper is to identify the differences in employer branding between the companies that participate and those that do not participate in employer ranking.

Design/methodology/approach

Quantitative data were collected through a survey from 188 companies operating on the Russian labour market. Descriptive statistics, frequency analysis, correlation analysis and multivariate analysis of variance were used to analyse the collected data.

Findings

The findings revealed specific profiles of the companies that participated and did not participate in employer ranking. Companies differed in their employer branding orientation, internal branding, employer branding strategy, employer branding programmes and employer branding communications tasks. At the same time, brand orientation did not differ between participants and non-participants of employer ranking.

Originality/value

This study integrates the employer brand equity theory and the signalling theory to better explain the differences between participants and non-participants of employer ranking.
Exploring the influence of government social media on cybersecurity compliance: employee attitudes, motivation and behaviors
Authors: Tran Dien Van , Nguyen Phuong Van , Nguyen Anh Thi Chau , Vrontis Demetris , Dinh Phuong Uyen
Published: November 2023

Purpose

This study aims to investigate the impact of employees’ engagement in government social media (GSM) on their cybersecurity compliance attitude, protection motivation and protective behavior, thereby contributing to effective cybersecurity practices at organizations.

Design/methodology/approach

A quantitative cross-sectional field survey was conducted to collect primary data in big cities and large provinces in Vietnam. The final data set of 323 responses was analyzed using the partial least squares-structural equation modeling approach to interpret the results and test research hypotheses.

Findings

Engagement in GSM positively influences employees’ cybersecurity compliance attitude (ATT). Perceived threat vulnerability and response efficacy also contribute to a positive compliance attitude, although self-efficacy has a negative impact. Moreover, the cybersecurity compliance ATT significantly explains the information protection motivation, which in turn influences employee protective behaviors. However, the relationship between compliance attitude and protective behaviors is weak, unlike previous studies that found a strong correlation.

Originality/value

Although recent studies have explored specific information security practices in corporate and home contexts, the influence of GSM on individuals’ cybersecurity behaviors has received limited attention because of its novelty. This study contributes to the existing body of knowledge by investigating the impact of GSM on cybersecurity behaviors. This study provides significant contributions to understanding social media’s effects of social media on individuals’ cultivation processes, by expanding upon the protective motivation theory and cultivation theory. The results lead to practical suggestions for organizational managers and policymakers so that they can enhance their understanding of the importance of cybersecurity, encourage the implementation of self-defense strategies and highlight the significance of threat and coping evaluations in influencing attitudes and motivations.
Commercial real estate prices in Europe after COVID-19
Authors: Hoesli Martin , Malle Richard
Published: November 2023

Purpose

The article aims to analyze the behavior of commercial real estate prices in Europe, with a focus on the post-coronavirus disease 2019 (COVID-19) pandemic period. The authors use national and city-level data for the various commercial real estate sectors in ten countries, as well as listed real estate data, to assess any differences across property type and space.

Design/methodology/approach

The authors analyze the behavior of commercial real estate prices after the COVID-19 pandemic, emphasizing differences across property types. For that purpose, the authors use national and city-level direct real estate data for the ten largest countries in terms of market capitalization, as well as listed real estate data. The article then turns to discussing the likely trajectory of commercial real estate prices in the future.

Findings

The recent rise in interest rates and geopolitical instability have affected prices differently across sectors. Industrial properties benefited from the pandemic, although prices declined significantly in 2022. Residential properties continued their upward price trend and have been the best-performing property type during the last two decades. Retail real estate continued its downward price trajectory. Thus far, office markets do not appear to be significantly affected by structural changes in the sector. The data for listed real estate markets in Europe suggest that markets bottomed out in early 2023.

Originality/value

This paper provides for a better understanding of the behavior of commercial real estate prices in Europe since the COVID-19 pandemic. The authors assess whether the effects found during the COVID-19 crisis were temporary or long-lasting. Also, many economic and political uncertainties have emerged since the beginning of the Ukraine war in February 2022, and it is important to analyze the effects of such uncertainties on commercial real estate prices.
The interconnectivity between Islamic financial literacy and financial sustainability: evidence from Muslim micro-entrepreneurs in Malaysia
Authors: Nik Azman Nik Hadiyan , Zulkafli Abdul Hadi , Masron Tajul Ariffin , Abdul Majid Abdul Rahman
Published: November 2023

Purpose

Financial illiteracy could pose a significant challenge to micro-entrepreneurs. There is a pressing need to foster financial literacy;, therefore, the purpose of this study is to examine particularly how Islamic financial literacy may enhance their businesses toward achieving financial sustainability.

Design/methodology/approach

This study uses quantitative methods. Three hundred (300) questionnaires were distributed to micro-entrepreneurs in three states in Malaysia, namely, Kedah, Kelantan and Terengganu. This study used the partial least squares (PLS) analysis using the SmartPLS 3.2.

Findings

The study found that the most robust Islamic financial literacy factors are financial behavior, followed by financial knowledge and financial attitude .The outcome of Islamic financial literacy, which is financial sustainability, also demonstrates a positive and significant relationship.

Social implications

All variables show a positive and significant relationship toward financial sustainability. Stated differently, micro-entrepreneurs are aware that understanding the basic concepts of Islamic finance may help them achieve long-term financial sustainability

Originality/value

This study incorporates Islamic financial concepts into financial literacy while also assessing demographic aspects like years of business operation and education as moderators, which were not considered by previous studies.
Artificial intelligence and value co-creation: a review, conceptual framework and directions for future research
Authors: Chandra Baby , Rahman Zillur
Published: November 2023

Purpose

Artificial intelligence (AI) has a significant impact on value co-creation (VCC). However, a study providing a comprehensive summary of the current state of the art and common ground of the two fields is missing. The current study aims to fill this gap by conceptualizing the role of AI in VCC and customer decision-making.

Design/methodology/approach

The study reviews literature on VCC and AI together, including a total of 108 articles. To bring the literature together, the authors adopted the antecedents-mediators-outcomes framework and narrative approach that helped them develop a framework by integrating the antecedents, mediators and outcomes of AI-facilitated VCC. Furthermore, the authors also operationalized existing literature to facilitate an understanding of the role of AI in customer decision-making.

Findings

The study, in addition to identifying the common theoretical grounds of VCC and AI (human behavior, cognition and social interactions), operationalizes AI functionality, its characteristics and customer characteristics as the antecedents of AI-facilitated VCC. Moreover, based on literature, on the continuum of low-to-high involvement, four types of decision-making were identified as mediator of the relationship between AI characteristics, customer characteristics and VCC. Additionally, the authors found different categorizations of AI in literature as archetypes to support various forms of VCC.

Originality/value

The study contributes to the literature of VCC and AI by construing a comprehensive framework for analyzing AI's impact on VCC, envisioning customer–AI interaction as continual exchange of advantages in which characteristics of AI and customers play a critical role in customer decision-making and shaping VCC.
Work engagement contagion from leader to follower through cognitive and affective mechanisms
Authors: Yun Mansik , Beehr Terry
Published: November 2023

Purpose

The main purpose of the current research is to examine affective and cognitive mechanisms by which the trickle-down effect of work engagement from leader to follower takes place.

Design/methodology/approach

The current research consisted of two independent studies. In study 1, an experience sampling method was used (N = 1,321 data points from 171 participants) to test within-person effects. In study 2, the authors recruited 266 employees working in 61 teams with two data collections one month apart, to test between-team effects among variables.

Findings

In two independent studies, leaders' work engagement resulted in followers engaging in surface acting (an affective process) and developing self-efficacy (a cognitive process), which in turn resulted in followers' work engagement.

Originality/value

The current research provides some clarifications to the literature on work contagion of engagement by examining dual mechanisms. In particular, although previous research emphasized the negative aspects of surface acting, the current research suggests that surface acting can be potentially helpful by facilitating the contagion effect of work engagement leaders to followers. Further, this research also examines the facilitative role of self-efficacy in mediating the relationship between a leader's work engagement and followers' work engagement. Finally, the authors conducted two independent studies that used different research designs, and results were consistent across the two studies, which can provide evidence for the robustness of the results.
Does intellectual capital influence banks' efficiency? Evidence from India using panel data tobit model
Authors: Maji Santi Gopal , Saha Rupjyoti
Published: November 2023

Purpose

This study investigates the effect of intellectual capital (IC) and its components on the technical efficiency of Indian commercial banks after controlling the influence of bank-specific and macroeconomic variables.

Design/methodology/approach

The study selects a sample of 37 listed Indian commercial banks from 2005 to 2019 and uses the two-step data envelopment analysis (DEA) approach. Banks' technical efficiency scores are first estimated, while the relationship between IC and technical efficiency is examined in the second stage using the panel data Tobit model.

Findings

This study's findings suggest a fluctuating trend in the technical efficiency of Indian banks. Notably, from 2015 onwards, a declining technical efficiency trend is observed for all banks. However, private-sector banks outperform public-sector banks in terms of technical efficiency. This study's regression analysis indicates a positive relationship between IC and banks' technical efficiency scores. Further, by decomposing IC into its components like human capital, structural capital and capital employed, the study's findings show that human capital and structural capital enhance banks' technical efficiency. Notably, capital employed reduces technical efficiency. Moreover, bank size, diversification, capitalization, net interest margin and the country's growth rate significantly drive Indian banks' efficiency. In contrast, their operating cost ratio and the country's inflation negatively influence the same.

Originality/value

This study makes a novel endeavor to examine the IC and bank's technical efficiency nexus in the Indian context, encompassing a period of landmark banking reforms.
A study on lender participation in peer to peer lending
Authors: Mukerjee Kaushik
Published: November 2023

Purpose

The purpose of this study is to examine the transformation expectations and well-being of lenders as a consequence of participation in peer-to-peer (p2p) lending in India. The study tested the influence of transformation expectations on well-being, social connectedness on transformation expectations and the influence of customer participation on financial empowerment of borrowers.

Design/methodology/approach

A cross-sectional survey research design was adopted to collect data from 434 customers in India. Structural equation modelling procedure was performed to test the hypothesized relationships.

Findings

The findings show that relational transformation expectations leads to well-being, while social connectedness influences self and relational transformation expectations. Further, customer participation has a positive influence on financial empowerment of borrowers.

Practical implications

Managers may use these findings to create suitable marketing strategies for increasing customer participation in p2p lending.

Originality/value

Previous studies on transformative services have shown that well-being can be achieved through participation in services that are transformative by design, while this study has established that lender participation in peer-to-peer lending can result in relational transformation expectations and lead to well-being. Also, the current study has shown that social connectedness is an antecedent of transformation expectations.
Sources of real exchange rate fluctuations in Egypt
Authors: Alabdulwahab Sami Zaki , Abou-Zaid Ahmed Sabry
Published: November 2023

Purpose

This paper aims to empirically investigate the sources of real exchange rate fluctuations in Egypt using structural vector autoregression (SVAR). The data covers the period between 1980 and 2016, where exchange regime has been changed more than once.

Design/methodology/approach

This paper investigates the source of real exchange rate fluctuations for the period between 1980 and 2016 using the SVAR method. The SVAR method will incorporate real gross domestic product (GDP), real effective exchange rate (REER) and price level in a multidimensional equations system. However, impulse response function (IRF) and error variance decompositions (EVDC) will be generated by the system to have a behavioral insight of real exchange rate in response to economic shocks.

Findings

The IRF and EVDC results indicate a significant impact of demand shocks over the real exchange rate relative to supply shocks and monetary shocks in the period between 1980 and 2016. On the other hand, monetary shocks will have a negligible effect on the real exchange rate in the short run and converging to its previous level in the covering period of the study.

Originality/value

In the best of the authors' knowledge, the topic of the source of the real exchange rate fluctuations in Egypt has not been discussed in a wide range due to the lack of time series data. However, this study provides constructed data for REER for Egypt with the published method in the International Monetary Fund (IMF). Furthermore, the study involves theoretical and econometric modeling to ensure the reliability of the economic results.
Towards a Typology of Contact‐Induced Change: Questions, Problems and the Path Ahead
Authors: Meyer Robin
Published: November 2023

The fields of linguistic typology, contact linguistics and historical linguistics frequently interact with one another and each draws on the insights gained in the others. To date, however, there is no effective and systematic cooperation between these subdisciplines, no database comparing the typological distribution of features with common outcomes or mechanisms of internal change and the results of contact‐induced change. Seeking to lay the foundation for just such a cooperation, this paper outlines and critically discusses the necessity, advantages and inherent limitations of a typology of contact‐induced change and how it may be used to better understand language change and language contact. It suggests that a database similar to WALS or Grambank, enriched with extra‐linguistic information, would be a suitable starting point for such an endeavour. At the example of contact‐induced morphosyntactic alignment change, some of the concrete issues of compiling a minimal dataset for one change are illustrated and the potential for typological insights highlighted.
Heterosis effect for larval performance of fall armyworm interstrain hybrids
Authors: Lan Laijiao , Nègre Nicolas
Published: November 2023

Spodoptera frugiperda, also known as fall armyworm (FAW), is an invasive crop pest that can feed on a variety of host plants, posing a serious threat to food security. There are two sympatric strains of FAW that are morphologically identical but described with different food preferences: the “rice strain” (SfR) and the “corn strain” (SfC). A few genetic loci exist to identify these two strains. Mitochondrial and Z‐chromosome‐linked haplotypes are the most used, but the biggest part of the genome displays little polymorphism between strains that could explain their adaptation to different plants. We have previously observed consistent transcription differences between the strains in both laboratory and natural populations. Therefore, we wonder if there are effects from host‐strain‐associated loci, maternally or paternally inherited, on FAW performance that could explain the divergence between the two FAW strains. To test this hypothesis, we first produced two F1 hybrid generations (SfR ♀ × SfC ♂, SfC ♀ × SfR ♂). These reciprocal hybrids should be heterozygous for all chromosomes except for the maternally inherited mitochondrial and sexual W chromosomes. To evaluate whether plant preference is determined by these genetic loci, we cultivated the two hybrids and the two parental strains in triplicate on an artificial diet and recorded several phenotypic traits such as weight over time, survival rate, emerging rate, developmental time, and sex ratio. Then, the same performance experiment was carried out on corn plants. Surprisingly, on the artificial diet, the two hybrid genotypes were both more performant than the two parental strains in terms of survival rate, pupal emerging rate, and developmental time, whereas they were intermediate to the inbred parental strains in pupal weight. On the corn plant diet, both hybrid genotypes outperformed the two parental strains in larval weight. Although these asymmetrical results revealed that mitochondrial or sex‐linked haplotypes alone cannot explain the performance differences, they suggested a heterosis effect in FAW. A reduction of the female number for the CR genotype and the decreased F1 offspring reproduction in both hybrids suggested the possibility of Haldane's rule, which might be explained by the dominance model.
n‐octyl acrylate is a candidate sex pheromone component involved in courtship in parasitoid wasp Microplitis mediator
Authors: Tao Yu‐Xiao , Shan Shuang , Dewer Youssef , Wang Shan‐Ning , Khashaveh Adel , Li Rui‐Jun , Zhang Yong‐Jun
Published: November 2023

Sex pheromones are considered to play critical roles in partner communication of most parasitic Hymenoptera. However, the identification of sex pheromone components remains limited to a few families of parasitoid wasps. In this study, we functionally characterized a candidate sex pheromone component in Microplitis mediator (Hymenoptera: Braconidae), a solitary parasitoid of Noctuidae insects. We found that the body surface extract from female wasps could significantly stimulate courtship behavior of males. Gas chromatography‐electroantennographic detection (GC‐EAD) analysis revealed that a candidate semiochemical from extract triggered significant electrophysiological response of antennae of males. By performing gas chromatography‐mass spectrometer (GC‐MS) measurement, GC‐EAD active compound was identified as n‐octyl acrylate, a candidate sex pheromone component in female M. mediator. In electroantennogram (EAG) tests, antennae of male wasps showed significantly higher electrophysiological responses to n‐octyl acrylate than those of females. Y‐tube olfactometer assays indicated that male wasps significantly chose n‐octyl acrylate compared with the control. Furthermore, male wasps showed a remarkable preference for n‐octyl acrylate in a simulated field condition behavioral trial; simultaneously, n‐octyl acrylate standard could also trigger significant courtship behavior in males. We propose that n‐octyl acrylate, as a candidate vital sex pheromone component, could be utilized to design behavioral regulators of M. mediator to implement the protection and utilization of natural enemies.
What adolescents see on Instagram: Content analysis of #intermittentfasting, #keto, and #lowcarb
Authors: Lister Natalie B. , Melville Hannah , Jebeile Hiba
Published: November 2023

Aim

To describe popular diet content visible on #intermittentfasting, #keto, and #lowcarb on adolescent social media accounts.

Methods

An adolescent Instagram profile captured 200 ‘top’ images from three popular diet hashtags (#intermittentfasting, #keto, and #lowcarb) across two timepoints. Images were coded using a pre‐determined ontology as food (core or discretionary; common foods/food groups), people (group, individual, before/after), or informative. Descriptive statistics were used to summarise these categories across hashtags.

Results

At the time of first data collection, there were 3.8 million #intermittentfasting, 19 million #keto, and 22 million #lowcarb posts on Instagram. At the second timepoint there were 4.3 million #intermittentfasting, 21.5 million #keto, and 24.3 million #lowcarb posts. Images tagged #intermittentfasting were categorised as 44% food, 39% people, 10% information; #keto were 64% food, 28% people, 5% information; and #lowcarb were 69% food, 14% people, 16% information. Food images mostly depicted animal proteins (58.6% of #intermittentfasting; 62.9% of #keto; and 40.1% of #lowcarb). Images of people were individual (44%) or before/after (39%); mostly female (77%), of white (53%) ethnicity. Across all posts, 12.5% were linked to a commercial product/program, and 2.3% provided nutrition information.

Conclusion

Diet‐related images visible when adolescents search #intermittentfasting, #keto, and #lowcarb on Instagram promote animal‐based foods with or without vegetables. These diet hashtags on Instagram do not provide nutrition information and are not helpful for young people searching for diet information online.
Effects of pear fruit‐derived volatiles and their concentrations on the responses of oriental fruit moths
Authors: Hu Xuefeng , Li Na , Cao Weiye , Wang Yi , Hu Rongshan , Li Jie , Ma Ruiyan , Kong Weina
Published: November 2023

Grapholita molesta (Busck) is an important pest of pear trees. Numerous esters accumulate consistently in mature pear fruits. However, little is known about the effects of single esters from pear fruits at different concentrations on the responses of male and female G. molesta. In this study, the responses of virgin males, virgin females, and gravid females to five esters (3‐methylbutyl acetate, ethyl hexanoate, ethyl butanoate, butyl acetate, and hexyl acetate) of pear fruits at three dosage levels (1, 5 and 10 μg/μL) were investigated using electroantennography (EAG), wind tunnel experiments, and field tests. Our results showed that ethyl butanoate (5 μg/μL) elicited higher EAG responses in virgin females and males than a mixture of all five volatiles, and elicited an equal EAG response to that for the mixture in gravid females, with all responses to ethyl butanoate and the mixture being higher than the response to hexane alone. For upwind flight, ethyl butanoate (5 μg/μL) excited equal moth flight–location behavior in virgin and gravid females to that for the mixture, which were both higher than the response to hexane. For close flight, ethyl hexanoate (5 μg/μL) and 3‐methylbutyl acetate (10 μg/μL) appeared to be the activating compounds, eliciting equal responses from virgin females to that of the mixture, and higher responses of gravid females to that of the mixture, both of which were higher than the responses to hexane. Upwind and close flight responses of virgin males were lower than those of virgin and gravid females. In field trials, we verified that traps baited with ethyl butanoate (5 μg/μL) captured more moths than the other esters. Therefore, from the esters and concentrations tested, we recommend ethyl butanoate (5 μg/μL) for potential use as an attractant for G. molesta in orchards.
Radiotherapy in nonagenarian patients: A 20‐year retrospective analysis in a single ternary centre
Authors: Katano Atsuto , Yamashita Hideomi
Published: November 2023

Introduction

The global burden of cancer and the ageing population is increasing, resulting in an increase in cancer incidence among elderly patients. This study aimed to evaluate the clinical outcomes and safety profile of radiotherapy in nonagenarians and to contribute to the existing knowledge on radiotherapy in elderly patients.

Methods

This retrospective analysis included nonagenarian patients who received external beam radiotherapy at a single centre in Japan between May 2003 and May 2023. Data, including patient demographics, tumour characteristics, treatment details, and clinical outcomes, were collected from medical records. Statistical analyses including survival and subgroup analyses were performed to summarize the data.

Results

The analysis included 124 nonagenarian patients who received 151 treatment courses. Among the patients with a median age of 92 years (range, 90–98 years), 71 received palliative‐intent radiotherapy and 53 underwent curative‐intent radiotherapy. The overall survival rates at 1 and 3 years after radiotherapy were 55.4% and 38.3%, respectively. Performance status and radiotherapy at the primary site were independent prognosis factors for improved overall survival, while age was not. The incidence rate of grades 3–5 radiation‐related toxicities was 3.4%, which is generally considered to be acceptable.

Conclusion

This study demonstrates that radiotherapy can be effectively and safely used in this age group, supporting its use as a treatment option for both palliative and curative goals. These results contribute to the existing body of evidence on radiotherapy in elderly patients and can guide clinical decision‐making in the management of nonagenarian patients with cancer.
Genomics and conservation: Guidance from training to analyses and applications
Authors: Schiebelhut Lauren M. , Guillaume Annie S. , Kuhn Arianna , Schweizer Rena M. , Armstrong Ellie E. , Beaumont Mark A. , Byrne Margaret , Cosart Ted , Hand Brian K. , Howard Leif , Mussmann Steven M. , Narum Shawn R. , Rasteiro Rita , Rivera‐Colón Angel G. , Saarman Norah , Sethuraman Arun , Taylor Helen R. , Thomas Gregg W. C. , Wellenreuther Maren , Luikart Gordon
Published: November 2023

Environmental change is intensifying the biodiversity crisis and threatening species across the tree of life. Conservation genomics can help inform conservation actions and slow biodiversity loss. However, more training, appropriate use of novel genomic methods and communication with managers are needed. Here, we review practical guidance to improve applied conservation genomics. We share insights aimed at ensuring effectiveness of conservation actions around three themes: (1) improving pedagogy and training in conservation genomics including for online global audiences, (2) conducting rigorous population genomic analyses properly considering theory, marker types and data interpretation and (3) facilitating communication and collaboration between managers and researchers. We aim to update students and professionals and expand their conservation toolkit with genomic principles and recent approaches for conserving and managing biodiversity. The biodiversity crisis is a global problem and, as such, requires international involvement, training, collaboration and frequent reviews of the literature and workshops as we do here.
Leveraging whole‐genome sequencing to estimate telomere length in plants
Authors: Zavala‐Paez Michelle , Holliday Jason , Hamilton Jill A.
Published: November 2023

Changes in telomere length are increasingly used to indicate species' response to environmental stress across diverse taxa. Despite this broad use, few studies have explored telomere length in plants. Thus, evaluation of new approaches for measuring telomeres in plants is needed. Rapid advances in sequencing approaches and bioinformatic tools now allow estimation of telomere content from whole‐genome sequencing (WGS) data, a proxy for telomere length. While telomere content has been quantified extensively using quantitative polymerase chain reaction (qPCR) and WGS in humans, no study to date has compared the effectiveness of WGS in estimating telomere length in plants relative to qPCR approaches. In this study, we use 100 Populus clones re‐sequenced using short‐read Illumina sequencing to quantify telomere length comparing three different bioinformatic approaches (Computel, K‐seek and TRIP) in addition to qPCR. Overall, telomere length estimates varied across different bioinformatic approaches, but were highly correlated across methods for individual genotypes. A positive correlation was observed between WGS estimates and qPCR, however, Computel estimates exhibited the greatest correlation. Computel incorporates genome coverage into telomere length calculations, suggesting that genome coverage is likely important to telomere length quantification when using WGS data. Overall, telomere estimates from WGS provided greater precision and accuracy of telomere length estimates relative to qPCR. The findings suggest WGS is a promising approach for assessing telomere length and, as the field of telomere ecology evolves, may provide added value to assaying response to biotic and abiotic environments for plants needed to accelerate plant breeding and conservation management.
Circulating monocytes expressing senescence‐associated features are enriched in COVID‐19 patients with severe disease
Authors: Lin Y. , Postma D. F. , Steeneken L. S. , Melo dos Santos L. S. , Kirkland J. L. , Espindola‐Netto J. M. , Tchkonia T. , Borghesan M. , Bouma H. R. , Demaria M.
Published: November 2023

Accurate biomarkers for predicting COVID‐19 severity have remained an unmet need due to an incomplete understanding of virus pathogenesis and heterogeneity among patients. Cellular senescence and its pro‐inflammatory phenotype are suggested to be a consequence of SARS‐CoV‐2 infection and potentially drive infection‐dependent pathological sequelae. Senescence‐associated markers in infected individuals have been identified primarily in the lower respiratory tract, while little is known about their presence in more easily accessible bio‐specimens. Here, we measured the abundance of senescence‐associated signatures in whole blood, plasma and peripheral blood mononuclear cells (PBMCs) of COVID‐19 patients and patients without an infection. Bulk transcriptomic and targeted proteomic assays revealed that the level of senescence‐associated markers, including the senescence‐associated secretory phenotype (SASP), is predictive of SARS‐CoV‐2 infection. Single‐cell RNA‐sequencing data demonstrated that a senescence signature is particularly enriched in monocytes of COVID‐19 patients, partially correlating with disease severity. Our findings suggest that monocytes are prematurely induced to senescence by SARS‐CoV‐2 infection, might contribute to exacerbating a SASP‐like inflammatory response and can serve as markers and predictors for COVID‐19 and its sequelae.
“Our Action Plan was Completely Changed”: Adapting, surviving, and collaborating through participatory action research during the Covid‐19 pandemic
Authors: Santiago Ortiz Aurora
Published: November 2023

This article discusses a participatory action research (PAR) team's response and adaptation to the COVID‐19 pandemic amid multiple crises in Puerto Rico. Drawing on an ethnographic study of a PAR collaboration, the article: 1) examines four key dilemmas that emerged during the study, 2) emphasizes the significance of reciprocal partnerships anchored in solidarity, and 3) underscores the vital role of a decolonial feminist approach in sustaining and maintaining the projects at the onset of the pandemic.
Clinical trial: A Mediterranean diet is feasible and improves gastrointestinal and psychological symptoms in irritable bowel syndrome
Authors: Staudacher Heidi M. , Mahoney Sophie , Canale Kim , Opie Rachelle S. , Loughman Amy , So Daniel , Beswick Lauren , Hair Chris , Jacka Felice N.
Published: November 2023

Background

Diet is fundamental to the care of irritable bowel syndrome (IBS). However, some approaches are not appropriate for individuals experiencing psychological symptoms.

Aims

To assess feasibility of a Mediterranean diet in IBS and its impact on gastrointestinal and psychological symptoms.

Methods

We recruited adults with Rome IV IBS and mild or moderate anxiety and/or depressive symptoms to an unblinded 6‐week randomised controlled trial. Patients were randomised to Mediterranean diet counselling or habitual diet. We collected gastrointestinal and psychological symptom data, dietary data and stool samples for metagenomic sequencing.

Results

We randomised 59 individuals (29 Mediterranean diet, 30 control); 48 completed the study. The Mediterranean Diet Adherence Screener score was higher in the Mediterranean diet group than controls at week 6 (7.5 [95% CI: 6.9–8.0] vs. 5.7 [5.2–6.3], p < 0.001), and there was a greater score increase than controls (2.1 [95% CI: 1.3–2.9] vs. 0.5 [95% CI: 0.1–1.0], p = 0.004), demonstrating Mediterranean diet feasibility. There was a greater proportion of gastrointestinal symptom responders in the Mediterranean diet group than controls (24/29, 83% vs. 11/30, 37%, p < 0.001) and depression responders (15/29, 52% vs. 6/30 20%, p = 0.015). There was no difference in FODMAP intake at week 6 (p = 0.51). Gastrointestinal adverse events were similar (p = 0.588). There were no differences in change in microbiome parameters between groups.

Conclusions

A Mediterranean diet is feasible in IBS and leads to improvement in gastrointestinal and psychological symptoms. Although this study was unblinded, these findings together with the broader benefits of the Mediterranean diet, provide strong impetus for future research in IBS.

Australia New Zealand Clinical Trials Registry: ACTRN12620001362987.
“I had no choice”: A mixed‐methods study on access to care for vaginal breech birth
Authors: Schafer Robyn , Dietrich Mary S. , Kennedy Holly Powell , Mulvaney Shelagh , Phillippi Julia C.
Published: November 2023

Introduction

Although current recommendations support vaginal breech birth as a reasonable option, access to breech birth in US hospitals is limited. This study explored the experiences of decision‐making and perceptions of access to care in people who transferred out of the hospital system to pursue home breech birth.

Methods

We conducted a mixed methods study of people with a singleton, term breech fetus who transferred out of the US hospital system to pursue home breech birth. Twenty‐five people completed an online demographic and psychosocial survey, and 23 (92%) participated in semi‐structured interviews. We used an interpretive description approach informed by situational analysis to analyze qualitative data about participants' experiences and perceived access to care.

Results

Of 25 individuals who left the hospital system to pursue a home breech birth, most felt denied informed choice (64%) and threatened or coerced into cesarean (68%). The majority reported low or very low autonomy in decision‐making (n = 20, 80%) and high decisional satisfaction using validated measures. Many participants felt safer in a hospital setting but were not able to access care for planned vaginal breech hospital birth, despite extensive efforts. Participants felt “backed into a corner” and “forced into homebirth,” perceiving a lack of access to safe and respectful care in the hospital system.

Conclusion

Some service users believe that home birth is their only option when they cannot access hospital‐based care for vaginal breech birth. Current barriers to care for breech birth limit birthing people's autonomy and may be placing them and their infants at increased risk.
Characteristics and outcomes of COVID‐19 in Chinese immune thrombocytopenia patients: A prospective cohort study
Authors: Chen Yunfei , Liu Jiaying , Shao Shuai , Song Zhen , Ma Yueshen , Tuo Yuanyuan , Fang Lijun , Xu Yanmei , Xu Bingqi , Gu Wenjing , Cao Xuan , Chen Jia , Yang Yu , Wang Panjing , Zhang Jing , Xu Yuan , Yu Dandan , Hou Pengxiao , Meng Ke , Li Zhirong , Liu Guanyu , Qu Xinmiao , Ji Lulu , Yang Renchi , Zhang Lei
Published: November 2023

The coronavirus disease 2019 (COVID‐19) pandemic has a significant impact on the immune system. This is the first and largest study on pre‐existing immune thrombocytopenia (ITP) patients infected with COVID‐19 in China. We prospectively collected ITP patients infected with COVID‐19 enrolled in the National Longitudinal Cohort of Hematological Diseases (NICHE, NCT04645199) and followed up for at least 1 month after infection. One thousand and one hundred forty‐eight pre‐existing ITP patients were included. Two hundred and twelve (18.5%) patients showed a decrease in the platelet (PLT) count after infection. Forty‐seven (4.1%) patients were diagnosed with pneumonia. Risk factors for a decrease in the PLT count included baseline PLT count <50 × 109/L (OR, 1.76; 95% CI, 1.25–2.46; p = 0.001), maintenance therapy including thrombopoietin receptor agonists (TPO‐RAs) (OR, 2.27; 95% CI, 1.60–3.21; p < 0.001) and previous splenectomy (OR, 1.98; 95% CI, 1.09–3.61; p = 0.03). Risk factors for pneumonia included age ≥40 years (OR, 2.45; 95% CI, 1.12–5.33; p = 0.02), ≥2 comorbidities (OR, 3.47; 95% CI, 1.63–7.64; p = 0.001), maintenance therapy including TPO‐RAs (OR, 2.14; 95% CI, 1.17–3.91; p = 0.01) and immunosuppressants (OR, 3.05; 95% CI, 1.17–7.91; p = 0.02). In this cohort study, we described the characteristics of pre‐existing ITP patients infected with COVID‐19 and identified several factors associated with poor outcomes.
Not all ballots should be considered equal: How education‐based dehumanization undermines the democratic social contract
Authors: Sainz Mario , Vázquez Alexandra
Published: November 2023

Less educated people are viewed negatively and their opinions are belittled in our society. Besides, along with other groups, they are underrepresented in the political arena which questions the legitimacy of democratic systems. Despite the existence of education‐based devaluation, research on how people dehumanize individuals and groups with lesser education and minimize their democratic rights is scarce. In this project, we provide correlational evidence that less (vs. highly) educated individuals and groups are dehumanized (Study 1a, N = 304) and their democratic rights (voting, running for office) are questioned (Study 1b, N = 504). Furthermore, we identified that dehumanization tendencies of the less (vs. highly) educated targets predict support for denying them voting rights or the capability to run for public candidacies (Study 2, N = 447). Finally, an experimental study confirmed that the target's educational background influences attributions of humanity, which in turn seem to affect the denial of democratic rights to the target (Study 3, N = 470). These findings suggest that education‐based dehumanization might undermine the inalienable democratic rights of lesser educated individuals and groups thus endangering the foundations of democratic systems.