bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial-Temporal Responses of Ecosystem Services to Land Use Transformation Driven by Rapid Urbanization: A Case Study of Hubei Province, China
Authors: Cui Xufeng , Liu Cuicui , Shan Ling , Lin Jiaqi , Zhang Jing , Jiang Yuehua , Zhang Guanghong
Published: December 2021

Exploring the changes of ecosystem services value caused by land use transformation driven by urbanization is crucial for ensuring the safety of the regional ecological environment and for enhancing the value of ecosystem services. Based on the land use remote sensing data during the rapid urbanization development period of Hubei Province from 1995 to 2015, this study analyzed the characteristics of land use/land cover change and land use transformation. The spatial–temporal response characteristics and evolution of ecosystem services value (ESV) to land use transformation driven by urbanization were measured by equivalent factor method, spatial autocorrelation analysis, hot spot analysis and gravity model. We found that: (1) Driven by urbanization, the most significant feature of land use transformation in Hubei Province was the expansion of the built-up land and the significant reduction of cropland and forest, among which 90% of the new built-up land was converted from cropland and forest. (2) This land use transformation became the main source of ESV losses. Especially, the sharp increase of the built-up land from 2010 to 2015, occupying cropland and forest, resulted in ESV losses of nearly USD 320 million. The service capacity of climate regulation, soil conservation, gas regulation and food production undertaken by cropland and forest decreased. (3) The ecosystem services value in the study area showed spatial distribution characteristics of high in the west and low in the middle and east regions. The center of gravity of ESV shifted from northwest to southeast. Due to the sharp increase of the built-up land from 2010 to 2015, the center of gravity shift rebounded. This study can help policymakers better understand the trade−offs between land use transformation and ecosystem services driven by urbanization.
Spatial Panel Data Analysis on the Relationship between Provincial Economic Status and Enrolment in the Social Security Scheme amongst Migrant Workers in Thailand, 2015–2018
Authors: Viriyathorn Shaheda , Phaiyarom Mathudara , Rueangsom Putthipanya , Suphanchaimat Rapeepong
Published: December 2021

Background: Thailand has a large flow of migrants from neighbouring countries; however, the relationship between economic status at the provincial level and the insured status of migrants is still vague. This study aimed to examine the association between provincial economy and the coverage of the Social Security Scheme (SSS) for migrants. Methods: Time-series data were analysed. The units of analysis were 77 provinces during 2015–2018. Data were obtained from the Social Security Office (SSO). Spatiotemporal regression (Spatial Durbin model (SDM)) was applied. Results: Migrant workers were mostly concentrated in Greater Bangkok, the capital city and areas surrounding it, but SSS coverage was less than 50%. However, the ratio of insured migrants to all migrants seemed to have positive relationship with the provincial economy in SDM. The ratio of insured migrants to all migrants was enlarged in all regions outside Greater Bangkok with statistical significance. Conclusions: Low enforcement on employment law in some areas, particularly Greater Bangkok, can result in lesser SSS coverage. The provincial economic prosperity did not guarantee large SSS coverage. Interventions to ensure strict insurance enrolment are required.
High-Temperature Disaster Risk Assessment for Urban Communities: A Case Study in Wuhan, China
Authors: Shan Zhuoran , An Yuehui , Xu L’ei , Yuan Man
Published: December 2021

High-temperature risk disaster, a common meteorological disaster, seriously affects people’s productivity, life, and health. However, insufficient attention has been paid to this disaster in urban communities. To assess the risk of high-temperature disasters, this study, using remote sensing data and geographic information data, analyzes 973 communities in downtown Wuhan with the geography-weighted regression method. First, the study evaluates the distribution characteristics of high temperatures in communities and explores the spatial differences of risks. Second, a metrics and weight system is constructed, from which the main factors are determined. Third, a risk assessment model of high-temperature disasters is established from disaster-causing danger, disaster-generating sensitivity, and disaster-bearing vulnerability. The results show that: (a) the significance of the impact of the built environment on high-temperature disasters is obviously different from its coefficient space differentiation; (b) the risk in the old city is high, whereas that in the area around the river is low; and (c) different risk areas should design built environment optimization strategies aimed specifically at the area. The significance of this study is that it develops a high-temperature disaster assessment framework for risk identification, impact differentiation, and difference optimization, and provides theoretical support for urban high-temperature disaster prevention and mitigation.
Caregivers of Individuals with Cancer in the COVID-19 Pandemic: A Phenomenological Study
Authors: Salha Leila Abou , Silva Julio Cesar Souza , Martins Cleusa Alves , Araújo Cristiane Soares da Costa , da Silva Edinamar Aparecida Santos , Alves Angela Gilda , de Paula Cácia Régia , de Lima Flavio Henrique Alves , de Moura Veidma Siqueira , de Menezes José Elmo , Brasil Virginia Visconde , Barbosa Maria Alves
Published: December 2021

Caregivers of individuals with cancer in the COVID-19 pandemic are faced with the demands of cancer and the health needs produced by it, along with their own health and self-care needs, and the uncertainties of expectations and risks. A qualitative analytical phenomenological study with caregivers of individuals with cancer registered at the state referral hospital supplying medications, who answered the sociodemographic assessment questionnaires and semi-structured questions about their feelings and perceptions in the COVID-19 pandemic. Bardin’s content analysis was used, with methodological quality assessed using SRQR Standards for Reporting Qualitative Research and the MAXQDA software. Most of the caregivers are women, married, Catholic, of low income and education, aged between 30 and 60 years, optimistic, comply with health guidelines regarding social distancing, use of masks, and routine hand hygiene, do not practice regular physical activities, mention concern for their own physical and financial survival, and that of their family. The main need identified in the affective sphere was to reframe contact with family members, seeking to strengthen the bonds of affection. The feeling of emotional vulnerability shows the importance of building effective public policies for social support consistent with the improvement of health care for this population.
Psychometric Qualities Evaluation of the Interdependent Happiness Scale across Malaysia, Philippines, and India
Authors: Tan Chee-Seng , Chong Shue-Ling , Masanda Argel Bondoc , George Sanju
Published: December 2021

The nine-item Interdependent Happiness Scale (IHS; Hitokoto & Uchida, 2015) is a self-report of interpersonal happiness that focuses on three dimensions: relationship-oriented happiness, quiescent happiness, and ordinary happiness. Few studies have evaluated the psychometric properties of the IHS in diverse cultural backgrounds and the findings are inconsistent. This study investigated whether the IHS has sound psychometric qualities in three Asian countries. University students from Malaysia (n = 263), Philippines (n = 239), and India (n = 310) answered the IHS and self-rated creativity scale. Confirmatory factor analysis on each sample supported the nine-item second-order model with error covariances. The overall IHS score showed good reliability in all samples. The subscales, however, had mixed results except for the Indian sample. Similarly, the convergent validity test showed mixed results while discriminant validity is supported in all samples except for the quiescent happiness subscale in the Indian sample. Concurrent validity was established across three samples by showing a positive relationship with creativity score. The results highlight that the higher-order structure of the IHS is consistently supported in different cultural contexts. However, some of the items are perceived differently and require further improvement in enhancing the cross-cultural usability of the IHS to measure socially-oriented happiness.
Image-Based Angular Distortion Metric of Map Projections by Using Surface Fitting for Noise Reduction
Authors: Yan Jin , Xu Tiansheng , Li Ni , Gong Guanghong
Published: December 2021

Measuring, analyzing, reducing, and optimizing distortions in map projections is important in cartography. In this study, we introduced a novel image-based angular distortion metric based on the previous spherical great circle arcs-based metric. Images with predefined patterns were used to generate distorted images using mapping software. The generated distorted images with known patterns were then exploited to calculate the proposed angular distortion metric. The mapping software performed the underlying transformation of map projections. Therefore, there was no direct explicit dependence on the forward equations of the map projections in our proposed metric. However, there were fairly large computation errors in the ordinary image-based approach without special correction. To reduce the error, we introduced surface-fitting-based noise reduction in our approach. We established and solved systems of linear equations based on bivariate polynomial functions in the process of noise reduction. Sufficient experiments were made to validate the proposed image-based metric and the accompanying noise reduction approach. In the experiment, the NASA G.Projector was employed as the mapping software for evaluating more than 200 map projections. Experimental results demonstrated that the proposed image-based approach and surface fitting-based noise reduction are feasible and practical for the evaluation of the angular distortion of map projections.
Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer’s Disease
Authors: Gonzalez-Rodriguez Melania , Villar-Conde Sandra , Astillero-Lopez Veronica , Villanueva-Anguita Patricia , Ubeda-Banon Isabel , Flores-Cuadrado Alicia , Martinez-Marcos Alino , Saiz-Sanchez Daniel
Published: December 2021

Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder, is characterized by executive dysfunction and memory impairment mediated by the accumulation of extracellular amyloid-β peptide (Aβ) and intracellular hyperphosphorylated tau protein. The hippocampus (HIPP) is essential for memory formation and is involved in early stages of disease. In fact, hippocampal atrophy is used as an early biomarker of neuronal injury and to evaluate disease progression. It is not yet well-understood whether changes in hippocampal volume are due to neuronal or glial loss. The aim of the study was to assess hippocampal atrophy and/or gliosis using unbiased stereological quantification and to obtain hippocampal proteomic profiles related to neurodegeneration and gliosis. Hippocampal volume measurement, stereological quantification of NeuN-, Iba-1- and GFAP-positive cells, and sequential window acquisition of all theoretical mass spectrometry (SWATH-MS) analysis were performed in AD and non-AD cases. Reduced hippocampal volume was identified using the Cavalieri probe, particularly in the CA1 region, where it correlated with neuronal loss and astrogliosis. A total of 102 downregulated and 47 upregulated proteins were identified in the SWATH-MS analysis after restrictive filtering based on an FC > 1.5 and p value < 0.01. The Hsp90 family of chaperones, particularly BAG3 and HSP90AB1, are closely related to astrocytes, indicating a possible role in degrading Aβ and tau through chaperone-mediated autophagy.
A Glance into MTHFR Deficiency at a Molecular Level
Authors: Savojardo Castrense , Babbi Giulia , Baldazzi Davide , Martelli Pier Luigi , Casadio Rita
Published: December 2021

MTHFR deficiency still deserves an investigation to associate the phenotype to protein structure variations. To this aim, considering the MTHFR wild type protein structure, with a catalytic and a regulatory domain and taking advantage of state-of-the-art computational tools, we explore the properties of 72 missense variations known to be disease associated. By computing the thermodynamic ΔΔG change according to a consensus method that we recently introduced, we find that 61% of the disease-related variations destabilize the protein, are present both in the catalytic and regulatory domain and correspond to known biochemical deficiencies. The propensity of solvent accessible residues to be involved in protein-protein interaction sites indicates that most of the interacting residues are located in the regulatory domain, and that only three of them, located at the interface of the functional protein homodimer, are both disease-related and destabilizing. Finally, we compute the protein architecture with Hidden Markov Models, one from Pfam for the catalytic domain and the second computed in house for the regulatory domain. We show that patterns of disease-associated, physicochemical variation types, both in the catalytic and regulatory domains, are unique for the MTHFR deficiency when mapped into the protein architecture.
Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells
Authors: Piatek Karina , Kutner Andrzej , Cacsire Castillo-Tong Dan , Manhardt Teresa , Kupper Nadja , Nowak Urszula , Chodyński Michał , Marcinkowska Ewa , Kallay Enikö , Schepelmann Martin
Published: December 2021

Background: Ovarian cancer (OC) is one of the most lethal cancers in women. The active form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25D3, calcitriol) has anticancer activity in several cancers, including ovarian cancer, but the required pharmacological doses may cause hypercalcemia. We hypothesized that newly developed, low calcemic, vitamin D analogs (an1,25Ds) may be used as anticancer agents instead of calcitriol in ovarian cancer cells. Methods: We used two patient-derived high-grade serous ovarian cancer (HGSOC) cell lines with low (13781) and high (14433) mRNA expression levels of the gene encoding 1,25-dihydroxyvitamin D3 24-hydroxylase CYP24A1, one of the main target genes of calcitriol. We tested the effect of calcitriol and four structurally related series of an1,25Ds (PRI-1906, PRI-1907, PRI-5201, PRI-5202) on cell number, viability, the expression of CYP24A1, and the vitamin D receptor (VDR). Results: CYP24A1 mRNA expression increased in a concentration-dependent manner after treatment with all compounds. In both cell lines, after 4 h, PRI-5202 was the most potent analog (in 13781 cells: EC50 = 2.98 ± 1.10 nmol/L, in 14433 cells: EC50 = 0.92 ± 0.20 nmol/L), while PRI-1907 was the least active one (in 13781 cells: EC50 = n/d, in 14433 cells: EC50 = n/d). This difference among the analogs disappeared after 5 days of treatment. The 13781 cells were more sensitive to the an1,25Ds compared with 14433 cells. The an1,25Ds increased nuclear VDR levels and reduced cell viability, but only in the 13781 cell line. Conclusions: The an1,25Ds had different potencies in the HGSOC cell lines and their efficacy in increasing CYP24A1 expression was cell line- and chemical structure-dependent. Therefore, choosing sensitive cancer cell lines and further optimization of the analogs’ structure might lead to new treatment options against ovarian cancer.
Impact of Magnetic Stimulation on Periodontal Ligament Stem Cells
Authors: Peluso Valentina , Rinaldi Laura , Russo Teresa , Oliviero Olimpia , Di Vito Anna , Garbi Corrado , Giudice Amerigo , De Santis Roberto , Gloria Antonio , D’Antò Vincenzo
Published: December 2021

The aim of this study was to evaluate the effect of a time-dependent magnetic field on the biological performance of periodontal ligament stem cells (PDLSCs). A Western blot analysis and Alamar Blue assay were performed to investigate the proliferative capacity of magnetically stimulated PDLSCs (PDLSCs MAG) through the study of the MAPK cascade (p-ERK1/2). The observation of ALP levels allowed the evaluation of the effect of the magnetic field on osteogenic differentiation. Metabolomics data, such as oxygen consumption rate (OCR), extracellular acidification rate (ECAR) and ATP production provided an overview of the PDLSCs MAG metabolic state. Moreover, the mitochondrial state was investigated through confocal laser scanning microscopy. Results showed a good viability for PDLSCs MAG. Magnetic stimulation can activate the ERK phosphorylation more than the FGF factor alone by promoting a better cell proliferation. Osteogenic differentiation was more effectively induced by magnetic stimulation. The metabolic panel indicated significant changes in the mitochondrial cellular respiration of PDLSCs MAG. The results suggested that periodontal ligament stem cells (PDLSCs) can respond to biophysical stimuli such as a time-dependent magnetic field, which is able to induce changes in cell proliferation and differentiation. Moreover, the magnetic stimulation also produced an effect on the cell metabolic profile. Therefore, the current study demonstrated that a time-dependent magnetic stimulation may improve the regenerative properties of PDLSCs.
“Turn on” Fluorescence Sensor of Glutathione Based on Inner Filter Effect of Co-Doped Carbon Dot/Gold Nanoparticle Composites
Authors: Le Thi-Hoa , Kim Ji-Hyeon , Park Sang-Joon
Published: December 2021

Glutathione (GSH) is a thiol that plays a significant role in nutrient metabolism, antioxidant defense and the regulation of cellular events. GSH deficiency is related to variety of diseases, so it is useful to develop novel approaches for GSH evaluation and detection. In this study we used nitrogen and phosphorus co-doped carbon dot-gold nanoparticle (NPCD–AuNP) composites to fabricate a simple and selective fluorescence sensor for GSH detection. We employed the reductant potential of the nitrogen and phosphorus co-doped carbon dots (NPCDs) themselves to form AuNPs, and subsequently NPCD–AuNP composites from Au3+. The composites were characterized by using a range of spectroscopic and electron microscopic techniques, including electrophoretic light scattering and X-ray diffraction. The overlap of the fluorescence emission spectrum of NPCDs and the absorption spectrum of AuNPs resulted in an effective inner filter effect (IFE) in the composite material, leading to a quenching of the fluorescence intensity. In the presence of GSH, the fluorescence intensity of the composite was recovered, which increased proportionally to increasing the GSH concentration. In addition, our GSH sensing method showed good selectivity and sensing potential in human serum with a limit of detection of 0.1 µM and acceptable results.
Vitamin D Immune-Mediated Responses and SARS-CoV-2 Infection: Clinical Implications in COVID-19
Authors: Gotelli Emanuele , Paolino Sabrina , Soldano Stefano , Cutolo Maurizio
Published: December 2021

Active vitamin D is a true steroid hormone with pleiotropic biological effects that go beyond the classical concept of bone metabolism regulation. In fact, adequate serum levels of 25-hydroxyvitamin D (>40 ng/mL) are required to support several biological functions, including the control of innate and adaptive immunity in course of infectious, inflammatory and autoimmune diseases. SARS-CoV-2 is responsible for the COVID-19 pandemic and deficient/insufficient serum levels of 25-hydroxyvitamin D are reported in very large cohorts of patients. Of note, vitamin D is involved in different pathophysiological processes, such as expression of SARS-CoV-2 receptor (ACE2), activation of innate (neutrophils with their extracellular traps, monocytes/macrophages, dendritic cells, natural killer cells) and adaptive (T and B lymphocytes) immune cells and clinical manifestations, such as coagulation/thrombotic disorders and acute respiratory distress syndrome. Randomized clinical trials regarding vitamin D supplementation in COVID-19 patients have shown favorable effects on the control of inflammation markers, arterial oxygen saturation/inspired fraction of oxygen ratio, admission to hospital intensive care units and mortality. A target of serum 25-hydroxyvitamin D > 50 ng/mL has been identified as protective for the course of COVID-19, potentially playing an ancillary role in the treatment of the disease.
Performance Evaluation of a Hybrid PSO Enhanced ANFIS Model in Prediction of Traffic Flow of Vehicles on Freeways: Traffic Data Evidence from South Africa
Authors: Olayode Isaac Oyeyemi , Severino Alessandro , Tartibu Lagouge Kwanda , Arena Fabio , Cakici Ziya
Published: December 2021

In the last few years, there has been a significant rise in the number of private vehicles ownership, migration of people from rural areas to urban cities, and the rise in the number of under-maintained freeways; all these have added to the perennial problem of traffic congestion. Traffic flow prediction has been recognized as the solution in alleviating and reducing the problem of traffic congestion. In this research, we developed an adaptive neuro-fuzzy inference system trained by particle swarm optimization (ANFIS-PSO) by performing an evaluative performance of the model through traffic flow modelling of vehicles on five freeways (N1,N3,N12,N14 and N17) using South Africa Transportation System as a case study. Six hundred and fifty (650) traffic data were collected using inductive loop detectors and video cameras from the five freeways. The traffic data used for developing these models comprises traffic volume, traffic density, speed of vehicles, time, and different types of vehicles. The traffic data were divided into 70% and 30% for the training and validation of the model. The model results show a positively correlated optimal performance between the inputs and the output with a regression value R2  of 0.9978 and 0.9860 for the training and testing. The result of this research shows that the soft computing model ANFIS-PSO used in this research can model vehicular traffic flow on freeways. Furthermore, the evidence from this research suggests that the on-peak and off-peak hours are significant determinants of vehicular traffic flow on freeways. The modelling approach developed in this research will assist urban planners in developing practical ways to tackle traffic congestion and assist motorists and pedestrians in travel behaviour decision-making. Finally, the approach used in this study will assist transportation engineers in making constructive and safety dependent guidelines for drivers and pedestrians on freeways.
Conversion of Mixtures of Soybean Curd Residue and Kitchen Waste by Black Soldier Fly Larvae (Hermetia illucens L.)
Authors: Li Xinfu , Zhou Zhihao , Zhang Jing , Zhou Shen , Xiong Qiang
Published: December 2021

The production of insect biomass from organic waste is a major challenge in terms of reducing the environmental impacts of waste and maintaining feed and food security. The feasibility of the co-conversion of soybean curd residue (SCR) and kitchen waste (KW) to breed black soldier fly (BSF, Hermetia illucens) larvae was evaluated so as to enhance biomass conversion efficiency and supply animal feed and allow it to be used in biodiesel production. Co-digestion was found to significantly increase larval yield, bioconversion rate, and bioaccumulation of lipid. Partial least squares regression showed that the conversion of 30% SCR with 70% KW is an appropriate proportion. The appropriate performance parameters of BSF were: survival rate (98.75%), prepupal rate (88.61%), larval biomass (30.32 g fresh and 11.38 g dry mass), bioconversion rate (18.45%), efficiency conversion of ingested food (ECI) (28.30%), and FCR (2.51). Our results show that conversion of mixtures (e.g., SCR with KW) by BSF larvae (BSFL) could play an important role in various organic materials management.
Extant Genus in the Mesozoic: Paleoplatyura Meunier (Diptera: Keroplatidae) Found in the Cretaceous Amber of Myanmar
Authors: Ševčík Jan , Krzemiński Wiesław , Skibińska Kornelia
Published: December 2021

Three new species of Paleoplatyura Meunier, 1899, i.e., Paleoplatyura agnieszkae sp. nov., P. miae sp. nov., and P. magnifica sp. nov., are described and figured. The concept of the genus is briefly discussed, and its systematic position is clarified. A key to fossil species is provided. The genus Paleoplatyura is described from the Eocene Baltic amber. It is concluded that, in Baltic amber, this group is represented only by the type species, and the identity of the other two species is problematic. No additional specimens have been found so far in this amber. Therefore, the presence of as many as three new species in Burmese amber, certainly belonging to Paleoplatyura, is a confirmation of its occurrence already in the Mesozoic.
Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies
Authors: Barragán Rocío , Ortega-Azorín Carolina , Sorlí Jose V. , Asensio Eva M. , Coltell Oscar , St-Onge Marie-Pierre , Portolés Olga , Corella Dolores
Published: December 2021

Aging is a risk factor for several pathologies, restricting one’s health span, and promoting chronic diseases (e.g., cardiovascular and neurodegenerative diseases), as well as cancer. Telomeres are regions of repetitive DNA located at chromosomal ends. Telomere length has been inversely associated with chronological age and has been considered, for a long time, a good biomarker of aging. Several lifestyle factors have been linked with telomere shortening or maintenance. However, the consistency of results is hampered by some methodological issues, including study design, sample size, measurement approaches, and population characteristics, among others. Therefore, we aimed to systematically review the current literature on the effects of three relevant lifestyle factors on telomere length in human adults: physical activity, smoking, and sleep. We conducted a qualitative systematic review of observational and intervention studies using the Preferred Reporting Item for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The systematic literature search covered articles published in MEDLINE and EMBASE databases (from 2010 to 2020). A total of 1400 studies were identified; 83 were included after quality control. Although fewer sedentary activities, optimal sleep habits, and non- or ex-smoker status have been associated with less telomere shortening, several methodological issues were detected, including the need for more targeted interventions and standardized protocols to better understand how physical activity and sleep can impact telomere length and aging. We discuss the main findings and current limitations to gain more insights into the influence of these lifestyle factors on the healthy aging process.
Ibero-American Society of Interventionism (SIDI) and the Spanish Society of Vascular and Interventional Radiology (SERVEI) Standard of Practice (SOP) for the Management of Inferior Vena Cava Filters in the Treatment of Acute Venous Thromboembolism
Authors: De Gregorio Miguel A. , Guirola Jose A. , Sierre Sergio , Urbano Jose , Ciampi-Dopazo Juan Jose , Abadal Jose M. , Pulido Juan , Eyheremendy Eduardo , Lonjedo Elena , Guerrero Guadalupe , Serrano-Casorran Carolina , Pardo Pedro , Arrieta Micaela , Rodriguez-Gomez Jose , Bonastre Cristina , Behrens George , Lanciego Carlos , Ferral Hector , Magallanes Mariano , Mendez Santiago , Perez Mercedes , Gonzalez-Nieto Jimena , Kuo William T. , Jimenez David
Published: December 2021

Objectives: to present an interventional radiology standard of practice on the use of inferior vena cava filters (IVCFs) in patients with or at risk to develop venous thromboembolism (VTE) from the Iberoamerican Interventional Society (SIDI) and Spanish Vascular and Interventional Radiology Society (SERVEI). Methods: a group of twenty-two interventional radiologist experts, from the SIDI and SERVEI societies, attended online meetings to develop a current clinical practice guideline on the proper indication for the placement and retrieval of IVCFs. A broad review was undertaken to determine the participation of interventional radiologists in the current guidelines and a consensus on inferior vena cava filters. Twenty-two experts from both societies worked on a common draft and received a questionnaire where they had to assess, for IVCF placement, the absolute, relative, and prophylactic indications. The experts voted on the different indications and reasoned their decision. Results: a total of two-hundred-thirty-three articles were reviewed. Interventional radiologists participated in the development of just two of the eight guidelines. The threshold for inclusion was 100% agreement. Three absolute and four relative indications for the IVCF placement were identified. No indications for the prophylactic filter placement reached the threshold. Conclusion: interventional radiologists are highly involved in the management of IVCFs but have limited participation in the development of multidisciplinary clinical practice guidelines.
Association between Non-HDL-C/HDL-C Ratio and Carotid Intima–Media Thickness in Post-Menopausal Women
Authors: Iannuzzi Arcangelo , Giallauria Francesco , Gentile Marco , Rubba Paolo , Covetti Giuseppe , Bresciani Alessandro , Aliberti Emilio , Cuomo Gilanluigi , Panico Camilla , Tripaldella Maria , Giusti Maria Ausilia , Mattina Alessandro , Iannuzzo Gabriella
Published: December 2021

Atherogenic lipoproteins (particularly, very low-density lipoproteins, VLDL) are associated with subclinical atherosclerosis. The present study aims at evaluating whether routinely analysed lipid parameters are associated with carotid intima–media thickness, a proxy for subclinical atherosclerosis. Lipid parameters from 220 post-menopausal women undergoing ultrasound investigation of the carotid arteries were analysed. Forty-five percent of women showed subclinical atherosclerosis on carotid ultrasound. The mean carotid intima–media thickness was 1.26 ± 0.38 mm. The mean value of the non-HDL-C/HDL-C ratio was 3.1 ± 1.2. Univariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima–media thickness (r = 0.21, p = 0.001). After adjusting for cardiovascular risk factors (age, systolic blood pressure, smoking, body mass index Homeostasis model assessment: insulin resistance and high-sensitivity C-Reactive-Protein), multivariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima–media thickness (β = 0.039, p = 0.04). Logistic regression analysis showed that the highest tertile of the non-HDL-C/HDL-C ratio was associated with the presence of carotid plaques (OR = 3.47, p = 0.003). Finally, a strong correlation between non-HDL-C/HDL-C ratio and cholesterol bound to VLDL (r = 0.77, p < 0.001) has been found. Non-HDL-C/HDL-C ratio is associated with the presence of carotid atherosclerosis in post-menopausal women and is strongly correlated to VLDL-C levels.
Age-Related Alterations of Hyaluronan and Collagen in Extracellular Matrix of the Muscle Spindles
Authors: Fan Chenglei , Pirri Carmelo , Fede Caterina , Guidolin Diego , Biz Carlo , Petrelli Lucia , Porzionato Andrea , Macchi Veronica , De Caro Raffaele , Stecco Carla
Published: December 2021

Background: Muscle spindles (MSs) play a crucial role in proprioception and locomotor coordination. Although the elasticity and viscosity of the extracellular matrix (ECM) within which MSs are embedded may play a key role in MS function, the impact of aging on ECM components is unclear. The aim of the current study was to investigate the age-related physiological changes of the ECM and to verify if these could be due to alterations of the environment directly surrounding MSs. Methods: Hematoxylin Eosin and picrosirius-red staining was carried out; collagen types I (COLI) and III (COLIII) were assessed, and biotinylated hyaluronan binding protein (HABP) immunohistochemical analysis was undertaken to evaluate alterations of the ECM in the intramuscular connective tissue (IMCT) of the hindlimbs of C57BL/6J male mice. Assessments were carried out on 6-week-old (Group A), 8-month-old (Group B), and 2-year-old (Group C) laboratory mice. Results: The capsule’s outer layer became progressively thicker with aging (it was 3.02 ± 0.26 μm in Group A, 3.64 ± 0.31 μm in Group B, and 5.81 ± 0.85 μm in Group C). The collagen in IMCT around and within the MSs was significantly higher in Group C, but there were no significant differences between Groups A and B. The MS capsules and continuous IMCT were primarily made up of COLI and COLIII. The average optical density (AOD) values of COLI in IMCT surrounding MS were significantly higher after aging (p < 0.05), but there were no significant differences in COLIII in the three groups (p > 0.05). HA was present in IMCT and filled the MSs capsule. The AOD of HABP of MS showed that there were lower HA levels in Group C with respect to Group A (p = 0.022); no significant differences were noted neither between Groups A and B nor between Groups B and C (p > 0.05). Conclusion: Age-related collagen accumulation and lower HA in the ECM in which the MSs were embedded may probably cause more stiffness in the ECM in vivo, which could help to partly explain the peripheral mechanisms underlying the age-related decline in functional changes related to MSs.
Development of a Low-Cost Wire Arc Additive Manufacturing System
Authors: Navarro Miguel , Matar Amer , Diltemiz Seyid Fehmi , Eshraghi Mohsen
Published: December 2021

Due to their unique advantages over traditional manufacturing processes, metal additive manufacturing (AM) technologies have received a great deal of attention over the last few years. Using current powder-bed fusion AM technologies, metal components are very expensive to manufacture, and machines are complex to build and maintain. Wire arc additive manufacturing (WAAM) is a new method of producing metallic components with high efficiency at an affordable cost, which combines welding and 3D printing. In this work, gas tungsten arc welding (GTAW) is incorporated into a gantry system to create a new metal additive manufacturing platform. Design and build of a simple, affordable, and effective WAAM system is explained and the most frequently seen problems are discussed with their suggested solutions. Effect of process parameters on the quality of two additively manufactured alloys including plain carbon steel and Inconel 718 were studied. System design and troubleshooting for the wire arc AM system is presented and discussed.
Effect of Ovality Length on Collapse Strength of Imperfect Sandwich Pipes Due to Local Buckling
Authors: Li Ruoxuan , Chen Bai-Qiao , Guedes Soares C.
Published: December 2021

The effect of ovality length on imperfect sandwich pipes is investigated using the finite element method in the scenario of local buckling under external pressure. First, the finite element model of the imperfect sandwich pipelines is established in ANSYS and is validated by comparing the results from numerical simulation with those from experiments. Then, the effect of ovality features on the collapse strength of the sandwich pipes is studied. At last, based on the calculation results from 1200 cases, a prediction equation is proposed to represent the relationship between collapse strength and ovality length of imperfect sandwich pipes. Good agreement is achieved between the proposed equation and the calculation results, leading to the conclusion that the proposed simplified model can be an efficient tool in the evaluation of the local collapse strength of subsea sandwich pipes under external pressure.
The Trade-Offs between Supply and Demand Dynamics of Ecosystem Services in the Bay Areas of Metropolitan Regions: A Case Study in Quanzhou, China
Authors: Shui Wei , Wu Kexin , Du Yong , Yang Haifeng
Published: December 2021

Bay areas are endowed with unique sea and land resources, location advantages, and high environmental carrying capacities. The rapid urbanization process has intensified the demand for limited natural resources, leading to a series of problems in coastal zones such as land use conflicts and the degradation of ecosystem services. Taking Quanzhou, a bay city in a metropolitan region, as an example, this paper established an accounting model of ecosystem services supply and consumption demand based on multisource data (meteorological site data, land use data and statistical data). We estimated the supply capacity and consumption demand of provisioning services, regulating services, and cultural services in Quanzhou from 2005 to 2015. In addition, the supply and demand of ecosystem services were simulated for 2030 under different scenarios. The results showed that the supply capacity of ecosystem services in Quanzhou was greater than the demand in general, but the supply-demand difference showed a gradual decrease. The high-value areas of supply capacity were concentrated in the upstream basin in the non-bay area, while the high-value areas of consumption demand were located downstream of the river basin in the bay area. The supply-demand difference in the bay area was negative, indicating that it was in a state of supply-demand imbalance and that the ecological security was under threat. Among the three simulated scenarios in 2030, the balance between supply and demand declined compared with the results of 2015, with the most serious decline in the natural scenario. The method to quantify the evolution of spatial and temporal patterns in supply and demand of ecosystem services could provide a decision-making reference for natural resource management in Quanzhou. This is conducive to the improvement and establishment of urban ecological security research systems, especially in bay areas that are lacking research.
Assemblage Characteristics of Butterflies and Carabid Beetles as a Function of Soil Characteristics and Plant Diversity in Differently Managed Fields, Forests and Ecotones: A Case Study in Tuczno Forest District, Poland
Authors: Szyszko-Podgórska Katarzyna , Dymitryszyn Izabela , Jankiewicz Urszula , Kondras Marek , Żyfka-Zagrodzińska Ewa , Schwerk Axel
Published: December 2021

A drastic decline in insect fauna on a large scale has been reported. We assume that this is a multifactorial problem involving biotope types and plant diversity, soil characteristics and human activity (management of areas). The aim of our study was to analyze diversity patterns of carabid beetles and butterflies as predatory and phytophagous arthropod groups in response to soil characteristics and plant diversity in different types of ecosystems and ecotones with diverse management situated in a heterogeneous landscape composed of different forests, agricultural and post-agricultural areas of different stages of succession and watercourses and mires in north-western Poland. Three different forests, three fallows, two meadows and two ecotones, differing with respect to the involved ecosystems, were included in the study. Our results showed that the study site types differed with respect to soil characteristics and plant diversity, but ecotones were not characterized by explicitly higher diversity in these parameters. For both carabid beetles and butterflies, characteristic assemblages for individual study sites could be demonstrated. We could also show differences in the most important factors between these two taxonomic groups. We assume that management type is important regarding ecosystem characteristics and biodiversity. Large-scale management strategies are necessary in order to maintain or create landscapes with high natural qualities.
Making Intangibles Tangible: Identifying Manifestations of Cultural Ecosystem Services in a Cultural Landscape
Authors: Jiang Wei , Marggraf Rainer
Published: December 2021

The assessment of cultural ecosystem services (CES) has proved challenging due to their intangible, non-material and invisible characteristics. A number of methods for evaluating CES have been developed, which depend mostly on subjective perceptions and behavior. An objective direction for considering CES is proposed based on the assumption that making use of CES leaves visible manifestations in the physical landscape and human society. The approach developed in this paper attempts to follow this direction by identifying a large amount of manifestations that reflect a wider range of CES types. This approach is applied to a case study of the Weser River in Germany, showing that the local people along the river have benefited from multiple CES of the Weser and created various manifestations of those CES. In the future researches, the identification and documentation of manifestations can be used to map the delivery of CES, to develop indicator systems for CES, to assess heritage value and identity, to indicate spatially explicit preferences on ecosystem characteristics and visual aesthetic qualities, to estimate the economic value of educational and inspirational service, to investigate sense of place, as well as to make better informed landscape management and nature protection.
Assessing Ecosystem Condition: Use and Customization of the Vegetation Departure Metric
Authors: Swaty Randy , Blankenship Kori , Hall Kimberly R. , Smith Jim , Dettenmaier Megan , Hagen Sarah
Published: December 2021

Assessment of ecosystem change often focuses on the degree of conversion and representation in networks of protected areas. While essential, these factors alone do not provide a holistic index of ecosystem conditions. Metrics that compare the current state of ecosystems to a meaningful reference condition can help identify “hidden” risks, lost functions, and provide conservation and management-relevant insights. Here we review a departure metric that can be used to measure ecosystem conditions and its implementation for all lands in the United States by the LANDFIRE Program. We then use two case studies to demonstrate how manually calculating the departure metric is used to explore under- and over-representation of structural stages. Finally, we document the assumptions, interpretation, and limitations of the departure metric, and discuss its current and possible future applications.
Cellulose and Its Nano-Derivatives as a Water-Repellent and Fire-Resistant Surface: A Review
Authors: Tavakoli Mehrnoosh , Ghasemian Ali , Dehghani-Firouzabadi Mohammad Reza , Mazela Bartłomiej
Published: December 2021

The inevitable destructive effects of moisture and temperature are obvious in cellulosic and nanocellulosic substrates. These materials are the main foundations of interdependent industries that produce products such as currency notes or high-quality packaging for sanitary, cosmetics, or ammunition in the defense industry. Therefore, it is essential to develop procedures to eliminate problems arising from humidity and fire to improve the quality of these green and sustainable materials. The production of waterproof and flame-resistant cellulose-based substrates has drawn increasing attention to resolve these drawbacks. In this review paper, we have initially summarized the most accessible cellulosic substrates, different kinds of nanocellulose, and the general information about water repellents and intumescent fireproof surfaces. Then, the potential and necessity of using cellulosic biobased substrates are addressed for use in modified shapes as waterproof and fire inhibitor coatings. Cost-effective, eco-friendly, and durable, dual-function coatings are also introduced as future challenges, which are exploited as water-repellents and flame-retardant cellulose-based surfaces for pulp and paper applications.
Enhanced Pyroelectric Performance of Lead-Free Zn-Doped Na1/2Bi1/2TiO3-BaTiO3 Ceramics
Authors: Patel Satyanarayan , Lalitha Kodumudi Venkataraman , Saurabh Nishchay
Published: December 2021

Lead-free Na1/2Bi1/2TiO3-BaTiO3 (NBT-BT) has gained revived interest due to its exceptionally good high power properties in comparison to commercial lead-based piezoelectrics. Recently, Zn-modified NBT-BT-based materials as solid solution and composites have been reported to exhibit enhanced depolarization temperatures and a high mechanical quality factor. In this work, the pyroelectric properties of Zn-doped NBT-6mole%BT and NBT-9mole%BT ceramics are investigated. The doped compositions of NBT-6BT and NBT-9BT feature a relatively stable pyroelectric property in a wide temperature range of ~37 K (300–330 K) and 80 K (300–380 K), respectively. A threefold increase in detector figure of merit is noted for 0.01 mole Zn-doped NBT-6mole% BT at room temperature in comparison to undoped NBT-6mole%BT and this increase is higher than those of major lead-free materials. A broad range of the temperature-independent behavior for the figures of merit was noted (303–380 K) for Zn-doped NBT-6mole% BT, which is 30 K higher than the undoped material. The large pyroelectric figures of merit and good temperature stability renders Zn-doped NBT-BT an ideal candidate for pyroelectric detector and energy harvesting applications.
Investigation of the Influence of Moisture Content on Fatigue Behaviour of HPC by Using DMA and XRCT
Authors: Markert Martin , Katzmann Josef , Birtel Veit , Garrecht Harald , Steeb Holger
Published: December 2021

High-performance concrete (HPC) is a topic of current research and construction projects, due to its outstanding compressive strength and durability. In particular, its behaviour under high-cycle fatigue loading is the focus of current investigations, to further pave the way to highly challenging long-lasting constructions; e.g., bridges or offshore buildings. In order to investigate the behaviour of HPC with different moisture contents in more detail, a mixture of silica sand and basalt aggregate with a maximum grain size of 8 mm was investigated with three different moisture contents. For this purpose, cyclic compressive fatigue tests at a loading frequency of 10 Hz and different maximum stress levels were performed. The main focus was the moisture influence on the number of cycles to failure and the development of concrete temperature and strain. In a further step, only the mortar matrix was investigated. For this purpose, the mixture was produced without basalt, and the moisture influence was investigated on smaller-sized test specimens using dynamic mechanical analysis (DMA) and X-ray computed tomography (XRCT). It was shown that the moisture content of HPC had a significant influence on the fatigue damage behaviour due to the number of cycles to failure decreasing significantly with increased moisture. In addition, there was also an influence on the temperature development, as well as on the strain development. It was shown that increasing moisture content was associated with an increase in strain development. XRCT scans, in the course of the damage phases, showed an increase in internal cracks, and made their size visible. With the help of DMA as a new research method in the field of concrete research, we were also able to measure damage development related to a decrease in sample stiffness. Both methods, XRCT and DMA, can be listed as nondestructive methods, and thus can complement the known destructive test methods, such as light microscopy.