bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges of Financial Globalization for the Development of the Territories of Ukraine: Directions of Minimization and Regulation
Authors:   Institute of Regional Research named after M. I. Dolishniy of the NAS of Ukraine, Mulska O. P. , Gudzovata O. О. ,   Lviv Business School of Ukrainian Catholic University
Published: March 2021

The active development of digital technologies, in particular Internet banking, algorithmic trading, big data industry, credit electronic platforms, blockchain and cryptocurrencies with a gradual abandonment of cash payments, causes a radical transformation of the financial system of most countries and creates new challenges in monetary lending and increases financial imbalances in the regional development of Ukraine. The article is aimed at deepening the theoretical and applied bases of the study of the mutual relationship between the challenges of globalization and financial imbalances in regional development, substantiating the main directions of their regulation, and minimizing the negative consequences of financial globalization. The article defines the need for a radical transformation of Ukraine’s regional financial systems and the development of a new policy to counteract the challenges of globalization in order to overcome financial imbalances in the regions of the country, namely: clear separation of powers of the subjects of regional regulation of the cryptocurrency market; implementation of financial regional monitoring and control over the subjects of primary financial monitoring; development of digital infrastructure, creation of conditions for the implementation of network segmentation technologies; retraining and social adaptation of financial workers due to the active development of information technologies. Counteracting financial crime, money laundering, cross-border and international crime is a key component in overcoming financial imbalances in the development of Ukrainian regions. It is proved that the introduction of a comprehensive system of minimizing the manifestations of shadowing the monetary sector will have positive results in the context of strengthening financial security.
Tourism Industry in the Context of the COVID-19 Pandemic: The Tendencies and Support Measures
Authors:   Lviv Polytechnic National University, Kulyniak I. Y. , Zhygalo I. I. ,   Lviv Polytechnic National University, Yarmola K. M. ,   Lviv Polytechnic National University
Published: March 2021

The coronavirus pandemic, which has engulfed almost all countries and caused a global crisis, has dealt a significant blow to many sectors of the economy, including the tourism sector. The tourism industry found itself in uncertain working conditions, which caused significant changes in the functioning of tourism entities. The article analyzes the current status and identifies tendencies in the development of the world tourism market in the context of the COVID-19 pandemic, as well as systematizes the measures implemented by Ukraine and other countries to stimulate and support the tourism industry. The contribution of tourism to the world GDP by the countries that are the most popular among tourists is analyzed. The percentage change in international tourist arrivals by region in 2020 and dynamics in destinations that were the most popular among tourists around the world in 2018–2020 is considered. It is identified that as a result of the pandemic, the indicators of tourism activities have decreased significantly, the tourism industry has suffered losses and there has been a significant reduction in tourist flows. The COVID-19 pandemic has caused a significant decrease in the number of international tourist arrivals in all countries. In addition, to achieve its goal, the article systematizes the measures to improve the tourism climate of countries, stimulation and support of the tourism industry both during the COVID-19 pandemic and the post-pandemic period. It is identified that among the measures to stimulate and support the tourism industry in most countries, the main focus is placed on domestic tourism, which is less dependent on the global coronavirus crisis and quarantine measures, as well as the introduction of online forms and the wider use of marketing and digital tools in the provision of tourist services. According to the results of the study, the authors substantiate the need to support the enterprises of the tourism industry and stimulate the demand for domestic tourism on the part of Ukrainian government.
Analyzing the Factors of Influence on Life Quality of the Population of Ukraine
Authors:   Research Centre of Industrial Problems of Development of NAS of Ukraine, Poliakova O. Y. , Hrypich O. V. ,   Academy of Financial Management, Levanda O. M. ,   Research Centre of Industrial Problems of Development of NAS of Ukraine
Published: March 2021

The article is concerned with developing methodical recommendations for assessing the factors of influence on life quality of the population of Ukraine. The algorithm for analysis of factors of influence on life quality of the population of Ukraine is proposed, which includes the following sequence of stages: formation of an information array of data on the level and quality of life of the population in the context of Ukrainian regions; identification of the factors influencing the quality of life of the population of Ukraine (selection of the method for extraction of factors, determination of the number of factors, assessment of factor loads, rotation of factors (if necessary), interpretation of factors); development of proposals for modifications of social standards. A generalization of the results of factor analysis for 2004–2018 allowed to allocate the factors of influence on life quality of the population of Ukraine: material well-being; demographic development; safety; stratification of the population; availability of medical care; ecological security. When forming social standards, it is necessary to take into account not only the norms of material wealth (income per person) and the provision of basic needs of the population (food availability), but also the availability of medical service, educational services and secure living conditions. In Ukraine, the stratification of the population has increased, so social standards should be aimed at reducing this stratification, including in the regional context, by stabilizing local budgets. The close relationship of employment and material well-being indicators justifies the need to stimulate employment of the population. Protecting the population from the negative consequences of ecological deterioration should be one of the areas of interaction between social policy and environmental policy.
Mixed Working Hours in the Conditions of the COVID-2019 Pandemic
Authors:   Kyiv National Economic University named after V. Hetman, Rudakova S. H. , Shchetinina L. V. ,   Kyiv National Economic University named after V. Hetman, Danylevych N. S. ,   Kyiv National Economic University named after V. Hetman, Kohdenko A. S. ,   Kyiv National Economic University named after V. Hetman
Published: March 2021

The article is aimed at valuating the experience of using mixed modes in the context of the COVID-2019 pandemic based on the results of sociological studies as well as substantiating the potential for the development of legal and regulatory provision. In the context of the pandemic, many enterprises switched to remote work and the working hours changed. For Ukraine, this is a new experience in implementing online work and a more flexible working day, so it is important to study this issue. During the COVID-2019 pandemic, enterprises faced the only legal opportunity to organize their activities through work at home. The authors carried out a sociological study on the use of mixed modes in the context of the COVID-2019 pandemic, which found out that 69.6% of respondents work remotely, 60.9% work on a flexible schedule, and 43.5% of respondents account for part-time work. 73.9% of the respondents faced mixed working modes. Regarding the preparedness of business owners to work in the new conditions, it is found out that the majority of respondents are satisfied with how their organization has switched to a remote or mixed form of work. Remote work can be combined with other modes, such as part-time or flexible working hours and full-time work. This combination can be considered as a mixed working time mode. According to the outcome of sociological researches, the use of mixed working hours is already a common reality, not an exception. Use of them has its own peculiarities in various spheres of activity, which requires further research. The survey identified the respondents both satisfied and dissatisfied with mixed working hours. It should be noted about the available potential to improve the legal and organizational-economic principles of using mixed modes of working time organization.
Intellectual Work as an Instrument to Ensure the Achievement of the Sustainable Development Goals
Authors:   Volodymyr Dahl East Ukrainian National University, Khandii O. O. , Kramchaninova M. D. ,   Volodymyr Dahl East Ukrainian National University, Liedovska A. I. ,   Volodymyr Dahl East Ukrainian National University
Published: March 2021

The article explores the role and contribution of intellectual work to the process of ensuring and improving the main aspects of human life in accordance with the Global Sustainable Development Goals (SDGs). Intellectual work is considered as an important resource for the creation of high-quality, innovative production, which provides for solution of important global problems of sustainable development. As part of a multilateral integrated approach, the impact of intellectual work results on the achievements of SDGs is researched. It is determined that the SDGs are interconnected and reinforce each other in the process of achievement, which is why their results are also comprehensive, that is, the result of improvements in the field of one goal is the way to achieve another one. A reflection of the dominant role of intellectual work in achieving the Sustainable Development Goals is the ninth SDGs – innovation and infrastructure. The development of technologies, creation of innovations and breakthrough solutions are crucial in the context of achieving the SDGs, and, accordingly, intellectual work, intellectual property and innovations are increasingly becoming socially significant and, due to the increased importance, need developing and implementing the policy of the integrity of scientific research along with protecting their results. Prospect for further research in this direction can be the issues of enhancing the efficiency of intellectual workers and increasing the opportunities to use the potential of intellectual activity for the further development of society.
The Organizational and Managerial Provision of Business Processes Reengineering at Enterprise in the Conditions of Digitalization
Authors:   Ukrainian Engineering and Pedagogical Academy, Prokhorova V. V. , Chobitok V. I. ,   Ukrainian Engineering and Pedagogical Academy
Published: March 2021

The article is aimed at analyzing the organizational and managerial provision of the reengineering of business processes at enterprise in the conditions of digitalization. According to the results of the research, it is identified that in turbulent economy conditions to improve the financial and economic state of business processes at domestic enterprises, there is a need to use innovative and progressive technologies, one of which is the reengineering technology. The main goal of business process reengineering is qualitative improvement of specific spheres of activity of enterprises. The essence of the formation of business processes of enterprise is the development and adaptation of the enterprise management system in accordance with modern challenges in the conditions of digitalization. For each business process, an aggregate of input resources, rules of work and expected results are formed. The digitalization technologies to provide the reengineering of business processes at enterprise allow to organize the most personalized interaction, which is preferred by most customers. Digital communication channels, artificial intelligence, robotics – all this should be implemented by the enterprise to achieve success. The digital transformation of business processes at enterprise is designed to provide conditions for making effective managerial decisions in order to quickly adapt the work to the requirements of our time and meet the needs of consumers. The process of providing the reengineering of business processes at enterprise on the basis of digitalization opens up opportunities for innovative ways of their development, which has become effective due to the large number of the instruments used.
Logistics and Innovation: Conception, Management Strategy and Interaction
Authors:   Uman National University of Horticulture, Kustrich L. А. , Gomeniuk M. O. ,   Uman National University of Horticulture
Published: March 2021

Innovation is a major factor in the future development of humanity in general and the economy in particular. Ukrainian economy is currently going through a difficult period, which requires the search for innovative ways out of this situation. One of the possible ways to solve this problem is to build an innovative logistics strategy. The article examines the conceptual foundations of innovative and logistical activities in Ukraine. The essence and significance of the logistical approach in the activities of enterprises are defined. It is noted that the essence of the logistical approach is the integration of individual links of the commodity chain into a single system that will ensure the most effective management of the continuous material flows. The relationship of logistics with innovative activity of enterprises is identified. The place of logistical approach to management of innovative activity of enterprise is determined. Management aspects of innovation and logistics development are researched. It is specified that in conditions of openness of implementation of innovative processes, those enterprises that can quickly implement an innovative idea do gain a competitive advantage. The basic components of the conception of innovation logistics are outlined. The main provisions of the logistic conception in the development and management of innovative activities of enterprises are distinguished. It is summarized that innovative activity on the basis of logistics forms an effective mechanism for innovative management of enterprises. The use of a logistical approach to the management of innovative activities contributes to the achievement of the goal and strategic targets of the enterprise, in particular, with its implementation, the efficiency of economic, financial, economic and sales activities increases; the target audience is expanding, resulting in an increased demand for products (goods) and services; profit increases; competitive positions in the market are strengthened.
ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells
Authors: Madan Vikas , Cao Zeya , Teoh Weoi Woon , Dakle Pushkar , Han Lin , Shyamsunder Pavithra , Jeitany Maya , Zhou Siqin , Li Jia , Nordin Hazimah Binte Mohd , Shi Jizhong , Yu Shuizhou , Yang Henry , Hossain Md Zakir , Chng Wee Joo , Koeffler H. Phillip
Published: March 2021

Recurrent loss-of-function mutations of spliceosome gene, ZRSR2, occur in myelodysplastic syndromes (MDS). Mutation/loss of ZRSR2 in human myeloid cells primarily causes impaired splicing of the U12-type introns. In order to further investigate the role of this splice factor in RNA splicing and hematopoietic development, we generated mice lacking ZRSR2. Unexpectedly, Zrsr2-deficient mice developed normal hematopoiesis with no abnormalities in myeloid differentiation evident in either young or ≥1-year old knockout mice. Repopulation ability of Zrsr2-deficient hematopoietic stem cells was also unaffected in both competitive and non-competitive reconstitution assays. Myeloid progenitors lacking ZRSR2 exhibited mis-splicing of U12-type introns, however, this phenotype was moderate compared to the ZRSR2-deficient human cells. Our investigations revealed that a closely related homolog, Zrsr1, expressed in the murine hematopoietic cells, but not in human cells contributes to splicing of U12-type introns. Depletion of Zrsr1 in Zrsr2 KO myeloid cells exacerbated retention of the U12-type introns, thus highlighting a collective role of ZRSR1 and ZRSR2 in murine U12-spliceosome. We also demonstrate that aberrant retention of U12-type introns of MAPK9 and MAPK14 leads to their reduced protein expression. Overall, our findings highlight that both ZRSR1 and ZRSR2 are functional components of the murine U12-spliceosome, and depletion of both proteins is required to accurately model ZRSR2-mutant MDS in mice.
Clonal evolution in chronic lymphocytic leukemia is scant in relapsed but accelerated in refractory cases after chemo(immune) therapy
Authors: Zapatka Marc , Tausch Eugen , Öztürk Selcen , Yosifov Deyan Yordanov , Seiffert Martina , Zenz Thorsten , Schneider Christof , Blöhdorn Johannes , Döhner Hartmut , Mertens Daniel , Lichter Peter , Stilgenbauer Stephan
Published: March 2021

Clonal evolution is involved in the progression of chronic lymphocytic leukemia (CLL). In order to link evolutionary patterns to different disease courses, we performed a long-term longitudinal mutation profiling study of CLL patients. Tracking somatic mutations and their changes in allele frequency over time and assessing the underlying cancer cell fraction revealed highly distinct evolutionary patterns. Surprisingly, in long-term stable disease and in relapse after long-lasting clinical response to treatment, clonal shifts are minor. In contrast, in refractory disease major clonal shifts occur although there is little impact on leukemia cell counts. As this striking pattern in refractory cases is not linked to a strong contribution of known CLL driver genes, the evolution is mostly driven by treatment-induced selection of sub-clones, underlining the need for novel, non-genotoxic treatment regimens.
T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective
Authors: Peters Fleur S. , Strefford Jonathan C. , Eldering Eric , Kater Arnon P.
Published: March 2021

Cellular immunotherapeutic approaches such as chimeric antigen receptor (CAR) T-cell therapy in chronic lymphocytic leukemia (CLL) thus far have not met the high expectations. Therefore it is essential to better understand the molecular mechanisms of CLLinduced T-cell dysfunction. Even though a significant number of studies are available on T-cell function and dysfunction in CLL patients, none examine dysfunction at the epigenomic level. In non-malignant T-cell research, epigenomics is widely employed to define the differentiation pathway into T-cell exhaustion. Additionally, metabolic restrictions in the tumor microenvironment that cause T-cell dysfunction are often mediated by epigenetic changes. With this review paper we argue that understanding the epigenetic (dys)regulation in T cells of CLL patients should be leveled to the knowledge we currently have of the neoplastic B cells themselves. This will permit a complete understanding of how these immune cell interactions regulate T- and B-cell function. Here we relate the cellular and phenotypic characteristics of CLL-induced T-cell dysfunction to epigenetic studies of T-cell regulation emerging from chronic viral infection and tumor models. This paper proposes a framework for future studies into the epigenetic regulation of CLL-induced Tcell dysfunction, knowledge that will help to guide improvements in the utility of autologous T-cell based therapies in CLL.
Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients
Authors: Ramos-Campoy Silvia , Puiggros Anna , Beà Sílvia , Bougeon Sandrine , Larráyoz María José , Costa Dolors , Parker Helen , Rigolin Gian Matteo , Ortega Margarita , Blanco María Laura , Collado Rosa , Salgado Rocío , Baumann Tycho , Gimeno Eva , Moreno Carolina , Bosch Francesc , Calvo Xavier , Calasanz María José , Cuneo Antonio , Strefford Jonathan C. , Nguyen-Khac Florence , Oscier David , Haferlach Claudia , Schoumans Jacqueline , Espinet Blanca
Published: March 2021

Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However, data comparing risk stratification by both methods are scarce. Herein, we assessed a cohort of 340 untreated CLL patients highly enriched in cases with complex karyotype (CK) (46.5%) with parallel CBA and GM studies. Abnormalities found by both techniques were compared. Prognostic stratification in three risk groups based on genomic complexity (0-2, 3- 4 and ≥5 abnormalities) was also analyzed. No significant differences in the percentage of patients in each group were detected, but only a moderate agreement was observed between methods when focusing on individual cases (κ=0.507; P<0.001). Discordant classification was obtained in 100 patients (29.4%), including 3% classified in opposite risk groups. Most discrepancies were technique-dependent and no greater correlation in the number of abnormalities was achieved when different filtering strategies were applied for GM. Nonetheless, both methods showed a similar concordance index for prediction of time to first treatment (TTFT) (CBA: 0.67 vs. GM: 0.65) and overall survival (CBA: 0.55 vs. GM: 0.57). High complexity maintained its significance in the multivariate analysis for TTFT including TP53 and IGHV status when defined by CBA (hazard ratio [HR] 3.23; P<0.001) and GM (HR 2.74; P<0.001). Our findings suggest that both methods are useful but not equivalent for risk stratification of CLL patients. Validation studies are needed to establish the prognostic value of genome complexity based on GM data in future prospective studies.
Experimental Design In The Ussr As Exemplified by Conceptual Design Of Household Luminaires
Authors: Vinogradov Vladimir V.
Published: March 2021

The article presents some models of household luminaires. Sculptural characteristics and creative solutions of luminaires designed in mid‑1980s are presented. Design approach and creative experiment techniques of design are described. Conceptual options and models of leading Soviet industrial engineers are shown. Methods of design experiments are revealed. Availability of non-conventional design approach (the experiment method) and necessity of its improvement are noted. It was the All-Union Research Institute of Technical Aesthetics (VNIITE) that established perfect conditions for this.
PENGEMBANGAN MAKNA TAFASSAHU FI AL-MAJALIS DALAM MASA PANDEMI COVID-19 (Analisis Ma’na cum Maghza terhadap Q.S. Al-Mujadilah [58]: 11)
Authors: Ni'am Aulanni'am
Published: March 2021

Pengembangan pemaknaan terhadap Al-Qur’an sangat penting bagi perkembangan khazanah keilmuan Al-Qur’an dan tafsir dalam dunia Islam. Perlu diketahui bahwa pengembangan makna bukan berarti menghapus makna awal sebuah ayat atau kata dalam al-Qur’an. Akan tetapi pengembangan ini merupakan upaya melengkapi literasi di bidang Al-Qur’an dan Tafsir. Tulisan ini akan menjabarkan pengembangan makna tafassahu fi al-majalis yang tertuang dalam Q.S. Al-Mujadilah (58): 11 dengan menggunakan pendekatan ma’na cum maghza yang digagas oleh Sahiron Syamsuddin. Sesuai dengan misi dari munculnya pendekatan tersebut, tulisan ini merupakan sebuah upaya untuk memberikan kontribusi dalam pengembangan penafsiran al-Qur’an di dunia Islam, di Indonesia khususnya.
Pengaruh Daya Beli Masyarakat dan Strategi Pemasaran Dalam Meningkatkan Hasil Penjualan Pada Bisnis Property
Authors: Budiman Johan
Published: March 2021

Bisnis properti di Indonesia telah berkembang semakin pesat, baik di Jakarta, Bandung,Surabaya dan beberapa kota besar lainnya, tetapi saat ini banyaknya property yang sedangmenghadapi masalah resiko pasar (market risk) dan resiko likuiditas (liquidity risk). Tujuanpenelitian ini adalah : untuk mengetahui adanya pengaruh yang positif antara daya beli masyarakatdalam meningkatkan hasil penjualan pada bisnis property, untuk mengetahui adanya pengaruh yangpositif antara strategi pemasaran dalam meningkatkan hasil penjualan pada bisnis property. Darihasil analisis pada tabel uji ANOVA atau nilai Ftest di dapati nilai Fhitung sebesar 26,653. Sedang Ftabel(∝ 0.05) untu N=30 adalah sebesar 0,29. Jadi Fhitung > Ftabel (∝ 0.05) atau 26,653 > 0,29, maka dapatdikatakan bahwa daya beli (X1) dan strategi pemasaran (X2) secara bersama-sama memangberpengaruh positif dan signifikan terhadap hasil penjualan (Y), nilai R (Index Determinasi) sebesar0,815. Hal ini menunjukan bahwa sebesar 81,5% pelayanan (X1) dan komunikasi (X2) secara simultan(bersama-sama) berpengaruh terhadap kepuasan pelanggan sedangkan sisanya sebesar 18,5%berhubungan dengan factor lainnya yang tidak teramati oleh penulis
Perancangan Sistem Informasi Puskesmas Menggunakan PHP dan Database MySQL
Authors: Sukisno Sukisno
Published: March 2021

Teknologi informasi sekarang ini berkembang sangat pesat. Banyak bermunculan aplikasiaplikasibaru yang mendukung kebutuhan masyarakat. Tidak bisa dipungkiri lagi bahwa teknologiinformasi sangat dibutuhkan oleh masyarakat untuk mempermudah pekerjaan, melancarkantransaksi, mencatat seluruh kegiatan dalam suatu bisnis proses suatu perusahaan. Pusat KesehatanMasyarakat, disingkat Puskesmas, adalah organisasi fungsional yang menyelenggarakan upayakesehatan yang bersifat menyeluruh, terpadu, merata, dapat diterima dan terjangkau olehmasyarakat, dengan peran serta aktif masyarakat dan menggunakan hasil pengembangan ilmupengetahuan dan teknologi tepat guna, dengan biaya yang dapat dipikul oleh pemerintah danmasyarakat. Upaya kesehatan tersebut diselenggarakan dengan menitikberatkan kepada pelayananuntuk masyarakat luas guna mencapai derajad kesehatan yang optimal, tanpa mengabaikan mutupelayanan kepada perorangan. Karena berhubungan dengan masyarakat luas, maka untuk transaksiyang ada di dalam sebuah Puskesmas harus dibuat cepat supaya efektif dan efisien. Berlatarbelakangkurang banyaknya aplikasi komputer yang ada di Puskesmas, maka peneliti melakukan perancangan,membuat desain, melakukan coding, testing dan implementasi terhadap aplikasi yang dibuat. Aplikasiini bertujuan untuk merancang sistem informasi layanan di Puskesmas, menyimpan data sebagaimaster data, mencatat seluruh kegiatan business process yang ada di Puskesmas.Kata kunci: Puskesmas, Kesehatan Masyarakat, Sistem Informasi
Analisa Perancangan Sistem Quiz Online Berbasis Web Pada SMA Arif Rahman Hakim Kota Tangerang Selatan
Authors: Mahmudin Mahmudin , Sujana Dadang
Published: March 2021

Abstrak. Seiring dengan perkembangan teknologi informasi (TI) yang semakin pesat, kebutuhan akansuatu konsep dan mekanisme belajar mengajar berbasis TI menjadi tidak dapat dihindari terutama dalamdunia pendidikan. Konsep yang kemudian disebut dengan sebutan quiz online ini membawa pengaruhterjadinya proses perubahan atau transformasi pendidikan dalam bentuk konvensional ke dalam bentukdigital, baik secara isi (content) dan sistemnya. Tujuan penelitian ini adalah Membangun suatu aplikasimodern yang dapat membantu proses belajar dan mengajar pada SMA Arif Rahman Hakim KotaTangerang Selatan. Membantu mempermudah proses belajar dan mengajar sehingga dapatmemanfaatkan waktu sebaik mungkin serta penyampaian materi dapat dilakukan kapan saja dan dimanasaja sesuai peraturan yang berlaku.Membantu para siswa agar dapat melakukan proses belajarmengajar menjadi lebih menyenangkan sehingga meningkatkan kemauan belajar siswa.Kata kunci: Quiz Online, Web, alat bantu ajar
Studi Kelayakan Bisnis Bengkel Bubut Cipta Teknik Mandiri (Studi Kasus di Perumnas Tangerang Banten)
Authors: Khamaludin Khamaludin , Juhara Sutresna , Sodikin Sodikin
Published: March 2021

Seiring berkembang pesatnya dunia industri otomotif namun tanpa diimbangi pendapatan konsumen yang sesuai menuntut pelaku usaha kecil dan menengah (UMKM) untuk meningkatkan kreativitas dalam meningkatkan efektivitas dan efisiensi di segala bidang untuk memenuhi kebutuhan konsumen. Dengan menganalisis aspek pasar menggunakan metode SWOT, studi kelayakan dari aspek finansial diharapkan mampu memberikan gambaran kelayakan pengembangan bisnis produksi dan jasa Bengkel Bubut Cipta Teknik Mandiri. Bisnis dengan jenis usaha membuat dan memasarkan aksesoris motor ini layak untuk dijalankan dengan pertimbangan studi kelayakan pasar dan analisis aspek finansial berupa Payback Period (PBP), Net Present Value (NPV), Internal Rate of Return (IRR), dan Break Even Point (BEP)
Upaya Meningkatkan Hasil Belajar Fisika dengan menggunakan media PhET simulation pada kelas XI IPA 2 SMA Manba’ul Ullum
Authors: Qoiriyah Waqidatul
Published: March 2021

Penelitian ini bertujuan untuk meningkatkan hasil belajar fisika peserta didik kelas XI dengan menggunakan media PhET simulation. Jenis penelitian yang dilakukan yakni penelitian tindakan kelas dengan tiga siklus. Terdapat lima tahap dalam penelitian ini, antara lain tahap persiapan, tahap perencanaan, tahap pelaksanaan, tahap observasi dan monitoring, dan tahap refleksi. Terdapat dua jenis instrumen yang digunakan dalam penelitian yakni kuantitatif dan kualitatif. Instrumen Kuantitatif berupa kuesioner dan tes kemampuan akademik. Kuesioner siswa diberikan di setiap akhir siklus, kuesioner untuk guru diberikan di awal dan digunakan dalam menganalisis kebutuhan guru. Sedangkan instrument kualitatif melalui observasi pembelajaran, wawancara, catatan lapanagan dan analisis dokumentasi. Dengan subyek penelitian siswa berjumlah 36 siswa. Setelah siklus rata rata kelas menjadi 64,3 namun belum mencapai KKM sehingga dilakukan siklus II. Dari siklus kedua diperoleh rata-rata kelas sebesar 67,8 peningkatan ini juga belum memenuhi KKM sehingga dilakukan siklus keIII kemudian didapat nilai rata-rata kelas sebesar 77,5. Berdasarkan data tersebut dapat disimpulkan bahwa penggunaan media pembelajaran PhET simulation dapat meningkatkan hasil belajar siswa kelas XI IPA2 SMA Manba’ul Ullum.
Analisis Vending Machine Menggunakan Metode Finite State Automata (FSA) Di Gedung Lama Universitas Islam Syekh Yusuf Tangerang
Authors: Sujana Dadang , Hanipah Ade , Agustina Elisa Dian , S Suwenti , Aulia Yasmin
Published: March 2021

Vending Machine merupakan mesin penjualan makanan atau minuman yang berkerja secara standalone. Vending Machine pula merupakan suatu alat pemasaran untuk memasarkan suatu product didalam nya. Perguruan tinggi merupakan suatu tempat yang merupakan titik dimana pemasaran Vending Machine ini banyak diminati oleh pengguna nya. Pada perguruan tinggi Universitas Islam Syekh Yusuf Tangerang memiliki 4 Vending Machine yang tersebar didalam nya dan menjual 20 product minuman di masing- masing mesin tersebut. Pada penelitian kali ini penulis meneliti beberapa perbedaan Vending Machine yang ada di perguruan tinggi tersebut.
Upaya Peningkatan Kemampuan Menulis Laporan Karya Ilmiah Remaja melalui pendekatan kontekstual di SMA Manba’ul Ullum
Authors: Qoiriyah Waqidatul , Syam Syahriani
Published: March 2021

Penelitian ini bertujuan untuk meningkatkan kemampuan menulis laporan karya ilmiah remaja dengan menerapkan pendekatan kontekstual di SMA Manba’ul Ullum.  Jenis penelitian yang dilakukan adalah penelitian tindakan kelas dengan dua siklus. Waktu penelitian berlangsung selama 3 bulan terhitung dari bulan September hingga November dengan sasaran 40 siswa. Terdapat dua jenis instrumen yang digunakan dalam penelitian yakni kuantitatif dan kualitatif.. Kuantitatif dilakukan melalui ujian akhir setelah siswa selesai mempresentasikan karya ilmiahnya., Sedangkan kualitatif dilakukan melalui observasi saat tindakan, wawancara, catatan lapanagan dan analisis dokumentasi. Observasi merupakan pengamatan yang dilakukan oleh observer  dan penasehat. Catatan lapangan dilakukan oleh masing-masing peneliti, observer dan kepala sekolah (Sebagai supervisi)..  Sebelum siklus nilai rata rata penulisan laporan 73, setelah diberikan tindakan (siklus 1) nilai rata rata penulisan laporan 78 namun peningkatan ini dirasa belum signifikan oleh peneliti, observer, dan kepala sekolah,  maka dilakukan siklus kedua dan memperoleh nilai rata rata penulisan laporan 80,4. Dari data sebelumnya dapat disimpulkan bahwa penerapan pendekatan kontekstual berhasil dalam  meningkatkan kemampuan siswa menulis laporan karya ilmiah remaja
Pengaruh Temperatur Pada Proses Pendegradasian Kain Poliester 100% Dengan Natrium Hidroksida (NaOH) Terhadap Derajat Putih (WHITENESS)
Authors: Darmojo Hardjito Sastro
Published: March 2021

Pengaruh Temperatur pada proses Pendegradasian Kain Poliester 100% dengan Natrium Hidroksida (NaOH) Terhadap Derajat Putih ( Whitenees). Weight reduce atau pendegradasian adalah tahapan proses produksi yang bertujuan memodifikasi dan menutupi kekurangan dan meningkatkan mutu bahan tekstil kain poliester 100%. Kelebihan  yang  diharapkan  yaitu  kelangsaian  kain,  menaikkan wettability,  moisture regain  dan  sifat antistatik,  naiknya ketahanan pengelupasan,  serta menaikkan  kemampuan pelepasan kotoran dan minyak. Perubahan sifat fisika yang terjadi kain poliester awal menjadi kain sesuai yang di inginkan dengan perlakuan proses penembahan NaOH, yaitu berupa kehilangan berat, kekuatan, ketahanan abrasi, koefisien gesekan dan kekakuan, setelah dianalisis rata-rata kehilangan berat kain poliester 100% berkisar antara 5-25% pada proses temperatur 115°-135°C. Hubungan yang terjadi bersifat linear negatif antara perubahan temperatur dengan derajat putih. Tingkat kelinearan negatif yang terbentuk sesuai dengan koefisien korelasi sebesar -98.6 % dengan persamaan garis  adalah Y= 89,594–0,173X. Artinya jika temperatur proses dinaikkan maka proses hidrolisis poliester akan semakin cepat dan hebat sehingga menyebabkan perubahan tekstur permukaan serat. Perubahan nilai derajat putih menjadi indikator telah berubahnya tekstur dan struktur permukaan serat karena reaksi hidrolisis poliester yang secara signifikan di pengaruhi faktor temperatur, tingkat kontribusi pengaruh temperatur terhadap perubahan derajat putih kain poliester  adalah 97,2%.  Kata kunci :   Pengurangan Berat, Hidrolisis Poliester, Derajat Putih.
A Review Article : Ethanol Fermentation by Saccharomyces cerevisiae using Agricultural Waste
Authors: Maftukhah Siti , Amyranti Mutia
Published: March 2021

Bioethanol is one of the most promising and eco-friendly alternatives to fossil fuels, which is produced from renewable sources. Bioethanol can be produced from different kinds of raw materials. Conventional crops such as corn and sugarcane are unable to meet the global demand of bioethanol production due to their primary value of food and feed. Agricultural wastes are cost effective, renewable and abundant. To do this, very high gravity (VHG) fermentation which involves use of medium containing high sugar concentration(>250g/L) must be implemented to achieve high ethanol concentration. However, VHG fermentation leads to significant stress for Saccharomyces cerevisiae due to osmotic pressure at the beginning of the fermentation and high ethanol content at the end. At this review, rice straw is the most abundant waste compared to the other major wastes and potentially produce 205 billion liters bioethanol per year, which is the highest among these four mentioned agricultural wastes.
Rancangan Sistem E-Learning Mahasiswa Fakultas Teknik Universitas Islam Syekh Yusuf Tangerang
Authors: Windyasari Vina Septiana , Qoiriyah Waqidatul
Published: March 2021

Pemanfaatan teknologi multimedia pada bidang pendidikan saat ini sangat penting digunakan sebagai metode pengajaran modern yang interaktif dan komunikatif  karena dapat belajar dimana saja dan kapan saja. Penelitian ini bertujuan membantu sistem  pengajaran yang lebih mudah dan khususnya dapat memotivasi mahasiswa di Fakultas Teknik Universitas Islam Syekh-Yusuf Tangerang, karena dapat dilakukan dimana saja, kapan saja dan juga dapat menggunakan seperti penggunaan media audio, audiovisual, maupun software komputer yang mampu meningkatkan mutu pembelajaran di dunia pendidikan baik secara kuantitas maupun kualitas. Aplikasi E-learning ini menggunakan Adobe Flash CS6 berbasis website, dengan metode pengembangan sistem menggunakan waterfall dan untuk mengidentifikasi masalah menggunakan analisa sistem PIECES (Performance, Information, Economy, Control, Efficency, Service). Analisis PIECES menghasilkan kelebihan dan kekurangan sistem lama yang dapat digunakan sebagai referensi pengambilan keputusan perancangan sistem informasi dan menghasilkan sistem pembelajaran yang dapat menjadi alternative pilihan belajar secara online. Rancangan sistem e-learning ini dapat memperkaya sistem e-learning yang sebelumnya, dan sistem ini dapat memberikan pelayanan yang lebih baik, yang secara langsung juga dapat memotivasi mahasiswa untuk tetap dapat melakukan tatap muka pembelajaran walaupun tidak berada di kelas, dan dapat membantu dosen juga mahasiswa pada pertemuan tatap muka yang kurang di kelas dapat dilakukan melalui sistem e-learning
Osmanlı Arşivi Kayıtları Işığında Kayseri’de Kolera (1893-1896)
Authors: ŞANAL Raziye , FEYİZ Fulya
Published: March 2021

İnsanlık tarihi boyunca dünya üzerinde yaşayan toplulukları ve devletleri etkisi altına alan muhtelif salgın hastalıklar görülmüştür. Salgın, yaşandığı topraklara sosyo-ekonomik ve siyasi açılardan ağır darbeler vurmuştur. İnsanoğlunun karşılaştığı bu yıkıcı darbelere sebebiyet veren salgın hastalıkları veba, frengi, sıtma, cüzzam, çiçek ve tifüs olarak sıralamak mümkündür. Teknoloji ve hızlı ulaşımın etkisiyle salgınların etki alanı kısa sürede genişlemiştir.

XIX. yüzyılda ise dünyayı etkileyen salgın hastalıkların başında kolera gelmektedir. Hindistan merkezli ortaya çıkan bu salgın, kısa sürede etki alanını genişletmiştir. Nitekim söz konusu hastalık Osmanlı Devleti’ne de sirayet etmiştir. Devlet, XIX. yüzyılda sağlık konusunda yaptığı birtakım yeniliklerle salgını kontrol altına almaya çalışmıştır. Gerek Avrupa’dan getirilen yeni tıbbi makineler gerekse batı menşeili ihdas edilen kurumlar vasıtasıyla salgınla mücadele etmiştir. Bu çalışma, Osmanlı Devleti’nde yaşanan kolera salgınını Kayseri bağlamında ele almaktadır.
Anpassning eller autonomi
Authors: Arvidson Malin , Linde Stig , Roberto Scaramuzzino
Published: March 2021

Internationella studier om villkoren för civila samhällets organisationer (CSO) belyser hur deras relation till offentlig sektor avgör karaktären på organisationernas utveckling. Den här artikeln bidrar till forskning inom området på två sätt. För det första utforskar studien svenska CSO som är verksamma inom det sociala området och hur deras relation till offentlig sektor påverkar deras utvärderingspraktik. Baserat på en enkätstudie riktad till CSO undersöker vi om organisationers granskning och utvärdering av den egna verksamheten kan ses som ett uttryck för institutionellt tryck, där relationen till offentlig sektor driver CSO:s utvärderingspraktik. Vikten av att uppmärksamma detta kommer ur antaganden att utvärderingsprinciper baserade på det offentligas logik, det vill säga kostnadseffektivitet, evidensbaserad praktik och konkurrensutsättning, kan hota organisationernas värdeintegritet; genom anpassning riskerar CSO att förlora särart och oberoende. För det andra bidrar studien till diskussioner som berör teoretiska antaganden att bidragsberoende, tvång på grund av kontraktsbaserade relationer eller ett verksamhetsområde präglat av lagstiftning påverkar organisationers strategier för avancerad utvärdering. Analysen stärker dock enbart antagandet om att närhet till lagstyrt verksamhetsområde präglar CSO:s utvärderingspraktik. Analysen stärker alltså inte antaganden om att resursberoende (med undantag för bidrag från landsting) och kontraktsbaserad relation påverkar CSO:s utvärderingsstrategier. Resultaten leder oss till att uppmärksamma hur relationer mellan offentligt och ideellt förstås utifrån ett historiskt perspektiv där just begreppet närhet kan rymma både instrumentella och inneboende värden. Den kunskapen är värdefull för vår förståelse av den svenska kontexten. Att studiens antaganden inte får stöd av analysen kan tolkas som ett uttryck för en relation mellan CSO och offentlig sektor som är präglad av ömsesidig förståelse, snarare än sådan maktasymmetri som följer resursberoende och avtalsbaserade relationer. Kunskapen är ett bidrag till forskningsdebatten om den institutionella kontextens påverkan på organisationer i fallet CSO, eftersom den uppmuntrar till en mer detaljerad bild av det institutionella tryckets dimensioner som består av både historiska och tidsbundna kontraktsbaserade relationer.
Ett förändrat vårdlandskap
Authors: Carlsson Eric
Published: March 2021

Digitaliseringen av svensk sjukvård har debatterats mycket i Sverige de senaste åren. Syftet med artikeln är att undersöka hur e-hälsa som begrepp tillskrivs mening i svensk medicinsk fackpress samt analysera de konfliktlinjer som formar denna betydelsebildning. Genom diskursanalys av 328 artiklar i tidningarna Dagens Medicin och Läkartidningen har tre organiserade metaforer identifierats. Dessa är e-hälsa som tävling, e-hälsa och ekonomi samt marknadifiering av e-hälsa som ett etiskt problem. Artikeln synliggör med hjälp av diskursanalys dominerande sätt att förstå och gestalta den förändring av svensk sjukvård som digitaliseringen har fört med sig. Den visar att e-hälsa ses både som en stor möjlighet för vården och som ett stort problem genom att teknologin och avregleringen av vården leder till stora kostnader för skattebetalare samt riskerar att förändra vad det innebär att vara både vårdgivare och patient.
Performance Assessment of Metaheuristic Algorithms for Structural Optimization Taking Into Account the Influence of Algorithmic Control Parameters
Authors: Dillen Wouter , Lombaert Geert , Schevenels Mattias
Published: March 2021

Metaheuristic optimization algorithms are strongly present in the literature on discrete optimization. They typically 1) use stochastic operators, making each run unique, and 2) often have algorithmic control parameters that have an unpredictable impact on convergence. Although both 1) and 2) affect algorithm performance, the effect of the control parameters is mostly disregarded in the literature on structural optimization, making it difficult to formulate general conclusions. In this article, a new method is presented to assess the performance of a metaheuristic algorithm in relation to its control parameter values. A Monte Carlo simulation is conducted in which several independent runs of the algorithm are performed with random control parameter values. In each run, a measure of performance is recorded. The resulting dataset is limited to the runs that performed best. The frequency of each parameter value occurring in this subset reveals which values are responsible for good performance. Importance sampling techniques are used to ensure that inferences from the simulation are sufficiently accurate. The new performance assessment method is demonstrated for the genetic algorithm in matlab R2018b, applied to seven common structural optimization test problems, where it successfully detects unimportant parameters (for the problems at hand) while identifying well-performing values for the important parameters. For two of the test problems, a better solution is found than the best solution reported so far in the literature.
c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation
Authors: Montecino Fabián , González Natalia , Blanco Natasha , Ramírez Manuel J. , González-Martín Adrián , Alvarez Alejandra R. , Olguín Hugo
Published: March 2021

Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle regeneration and maintenance. SCs function is critically dependent on two families of transcription factors: the paired box (Pax) involved in specification and maintenance and the Muscle Regulatory Factors (MRFs), which orchestrate myogenic commitment and differentiation. In turn, signaling events triggered by extrinsic and intrinsic stimuli control their function via post-translational modifications, including ubiquitination and phosphorylation. In this context, the Abelson non-receptor tyrosine kinase (c-Abl) mediates the activation of the p38 α/β MAPK pathway, promoting myogenesis. c-Abl also regulates the activity of the transcription factor MyoD during DNA-damage stress response, pausing differentiation. However, it is not clear if c-Abl modulates other key transcription factors controlling SC function. This work aims to determine the role of c-Abl in SCs myogenic capacity via loss of function approaches in vitro and in vivo. Here we show that c-Abl inhibition or deletion results in a down-regulation of Pax7 mRNA and protein levels, accompanied by decreased Pax7 transcriptional activity, without a significant effect on MRF expression. Additionally, we provide data indicating that Pax7 is directly phosphorylated by c-Abl. Finally, SC-specific c-Abl ablation impairs muscle regeneration upon acute injury. Our results indicate that c-Abl regulates myogenic progression in activated SCs by controlling Pax7 function and expression.
PFKFB3: A Potential Key to Ocular Angiogenesis
Authors: Zhou Zi-Yi , Wang Lin , Wang Yu-Sheng , Dou Guo-Rui
Published: March 2021

The current treatment for ocular pathological angiogenesis mainly focuses on anti-VEGF signals. This treatment has been confirmed as effective despite the unfavorable side effects and unsatisfactory efficiency. Recently, endothelial cell metabolism, especially glycolysis, has been attracting attention as a potential treatment by an increasing number of researchers. Emerging evidence has shown that regulation of endothelial glycolysis can influence vessel sprouting. This new evidence has raised the potential for novel treatment targets that have been overlooked for a long time. In this review, we discuss the process of endothelial glycolysis as a promising target and consider regulation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as treatment for ocular pathological angiogenesis.
Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects
Authors: Estupiñán H. Yesid , Berglöf Anna , Zain Rula , Smith C. I. Edvard
Published: March 2021

The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and survival of B-lineage cells and, hence, represents a suitable drug target. The number of BTK inhibitors (BTKis) in the clinic has increased considerably and currently amounts to at least 22. First-in-class was ibrutinib, an irreversible binder forming a covalent bond to a cysteine in the catalytic region of the kinase, for which we have identified 228 active trials listed atClinicalTrials.gov. Next-generation inhibitors, acalabrutinib and zanubrutinib, are approved both in the United States and in Europe, and zanubrutinib also in China, while tirabrutinib is currently only registered in Japan. In most cases, these compounds have been used for the treatment of B-lymphocyte tumors. However, an increasing number of trials instead addresses autoimmunity and inflammation in multiple sclerosis, rheumatoid arthritis, pemphigus and systemic lupus erythematosus with the use of either irreversibly binding inhibitors, e.g., evobrutinib and tolebrutinib, or reversibly binding inhibitors, like fenebrutinib. Adverse effects (AEs) have predominantly implicated inhibition of other kinases with a BTKi-binding cysteine in their catalytic domain. Analysis of the reported AEs suggests that ibrutinib-associated atrial fibrillation is caused by binding to ERBB2/HER2 and ERBB4/HER4. However, the binding pattern of BTKis to various additional kinases does not correlate with the common assumption that skin manifestations and diarrhoeas are off-target effects related to EGF receptor inhibition. Moreover, dermatological toxicities, diarrhoea, bleedings and invasive fungal infections often develop early after BTKi treatment initiation and subsequently subside. Conversely, cardiovascular AEs, like hypertension and various forms of heart disease, often persist.