bluuebunny/crossref_metadata_2025 huggingface dataset:
A Numerical Study addressing the Stress Distribution in Circular Steel Tube Confined Concrete Columns considering Various Concrete Strengths
Authors: Le Hoang An
Published: April 2023

The axially compressive behavior of Steel Tube Confined Concrete (STCC) columns has been experimentally investigated by many researchers throughout the world. However, it is extremely complicated to measure the stresses of steel tubes and concrete core in real tests. Therefore, to investigate the fundamental behavior of STCC columns under axial compression, this paper presents a numerical study that explores the stress distribution in steel tubes and concrete core. The circular STCC columns with the use of Normal Strength Concrete (NSC), High Strength Concrete (HSC), and Ultra-High Strength Concrete (UHSC) were simulated in a Finite Element Model (FEM) in ABAQUS. The material model for confined concrete incorporating a wide range of concrete strength values was developed in the simulation. The obtained from FEM curves of load versus strain of circular STCC columns were compared with those measured in real tests to verify the accurateness of the FEM. Deriving from the results of FEM, the stress states and their distribution in outer steel tubes and concrete core along the column height were described. Also, the longitudinal stresses on the cross-section of the concrete core were calculated corresponding with the load stage to quantify the strength enhancement of the concrete core due to the confinement effect from the steel tube. Furthermore, the confining pressure provided by the outer steel tube and impacting on the concrete core was plotted. Based on the findings in this paper, the effect of various concrete strengths on the stress distribution in circular STCC columns was investigated.
Adaptive Dynamic Cutting Force Control Analysis for Peripheral Milling
Authors: Slimani Abdesselem , Kherraf Allaoua , Zidani Kamel
Published: April 2023

The implementation of condition monitoring tools can improve plant availability and lower downtime costs in general. A reliable adaptive control system can prevent machine downtime or undesired situations such as chatter vibration and excessive tool wear, permitting the best utilization of a tool's life. This study used dynamic force analysis to create an adaptive dynamic control system for Computer Numerical Control (CNC) milling to adjust a controlled system for signals from offline measurements that will be processed and supplied back to the machine tool controller to correct cutting parameters. This paper describes a better adaptive control system for peripheral milling with helical end mills based on a dynamic cutting force model. This theoretical model is based on the oblique cutting principle and takes into account the effects of the size of undeformed chip thickness and the effective rake angle. Simulation results showed that the enhanced dynamic cutting-force model accurately predicted cutting forces in peripheral milling.
Numerical Simulation and Optimization of Methane Steam Reforming to Maximize H2 Production: A Case Study
Authors: Romao Estaner Claro , Siqueira Adriano Francisco , Martins Jairo Aparecido
Published: April 2023

Research in renewable energy, the preservation of the environment, and the reduction of energy generation costs are themes that go hand in hand. In this work, a case study was carried out that aims to maximize the production of hydrogen through Methane Steam Reforming. For this, several numerical simulations, considering a laminar flow regime in a chemical reactor with a catalyst, were developed with COMSOL Multiphysics. After an exploratory study of the data, a systematic optimization was developed using multivariate regression models formed by combinations of input parameters in an idealized reactor. The results showed that the proposed approach is capable of satisfactory optimization.
Controller Design based on Fractional Calculus for AUV Yaw Control
Authors: Abdulkader Rasheed
Published: April 2023

This research presents a fractional order integral controller strategy, which improves the steering angle for Autonomous Underwater Vehicles (AUVs). The AUV mathematical modeling is presented. A Fractional Order Proportional Integral (FOPI) control scheme is implemented to ensure the yaw angle stability of the AUV steering under system uncertainty. The FOPI controller is validated with MATLAB/Simulink and is compared to the conventional Integer Order PI (IOPI) controller to track the yaw angle of the structure. The simulation results show that the proposed FOPI controller outperforms the IOPI controller and improves the AUV system steering and the overall transient response while ensuring the system's stability with and without external disturbances such as underwater current and different loading conditions.
Implementation and Evaluation of a Low Speed and Self-Regulating Small Wind Turbine for Urban Areas in South Africa
Authors: Sithole Tshepo Samora , Veeredhi Vasudeva Rao , Sithebe Thembelani
Published: April 2023

A low-cost small 500W wind generator was used as a basis for the prototype development. The research was primarily focused on the determination of the type of aerofoil for improved rotor blades and pitch angle, and for adapting the number of blades in order to optimize the power output from the prototype, for low wind-speed inland conditions in Soweto. NACA-4412 type aerofoil was chosen as a departure point for the blade design, and a variation of the maximum pitch angle of 6°, 10°, and 12° at an optimum angle of attack of 5°, 7°, and 9° were implemented respectively for Designs 1, 2 and 3. With the Soweto area having an average wind speed of 2.3m/s (8.28km/h), 3-, 5-, and 7-blade sets were subsequently developed, implemented, and tested. Prototype 1 produced a maximum output power of 8.2W at 4.2km/h wind speed. Prototype 2 yielded a maximum output power of 12.5W at 4.2km/h, and Prototype 3, generated a very useful power output of 39.5W during testing. The maximum power output was achieved at an average wind speed of 1.17m/s (4.2km/h). Moreover, the developed prototype designs were also tested for self-regulation in case of high-speed gust conditions. Prototype 3, with a 12° maximum pitch angle during operation in high gust conditions, had its blades control high speed. A drawback pressure occurred on the back side of the blades and tangent drag was developed normally to the blade rotation direction, consequently limiting the maximum speed of the rotor and acting as a self-regulation mechanism with regard to maximum achievable speed. The other two designs suffered from over-speeding tendencies in high gust speed conditions, also causing noise and turbulence.
A Comparative Analysis of Seismic Site Response in Time and Frequency Domains
Authors: Boudina Tounsia , Bounouni Sofiane , Allout Naas
Published: April 2023

This study aims primarily to perform a comparative analysis of the seismic response of a soil profile, in the time and frequency domains, in order to evaluate the seismic response of soil subjected to seismic excitation. After a few remarks made on the responses given by the linear elasticity method for this type of problem, it was considered necessary to use SHAKE 2000 and PLAXIS in this study. The obtained results were then compared with those of the available theoretical predictions. Rock elasticity, viscous damping and damping by hysteresis, and the nonlinearity of the ground were then taken into account. In addition, comparisons between recorded responses were also conducted.
Influence of the Incorporation of Alluvial Sand on the Mechanical Behavior of Marl Soil
Authors: Bensaada َAbdelhalim , Choungache Belgacem , Zaitri Rbih
Published: April 2023

This study aims to evaluate the mechanical behavior of marl soil by replacing it with alluvial sand at 3, 5, and 10% by weight for a possible application in road geotechnics. After a geotechnical characterization of the materials used, the mixtures were characterized by the Atterberg limits test, the soil compressibility test, and the shear strength test. The results obtained showed that replacing a part of marl soil with alluvial sand had a positive impact on its mechanical behavior, as it improved cohesion and shear strength while significantly reducing compressibility and plasticity. These results confirm the possibility of using alluvial sand as a fine soil reinforcement or stabilization material.
Multi-Goal Feature Selection Function in Binary Particle Swarm Optimization for Power System Stability Classiﬁcation
Authors: Nguyen Ngoc Au , Le Trong Nghia , Nguyen Hoang Minh Vu
Published: April 2023

The input feature is vital for power system stability classification. Feature selection can reduce the size of the input feature, making classifier training easier, and the small size of the input feature subset also reduces the cost of purchasing sensor measurement equipment. Therefore, feature selection works require an efficient seeking method. Binary Particle Swarm Optimization (BPSO) is a simple and easy-to-implement evolutionary calculation technique. While the classification accuracy of BPSO is essential, it is also needed to drive the algorithm to minimize the number of variables. The proposed approach is to apply a multi-objective function to help the BPSO algorithm identify the subset of features that can achieve the minimum number of variables and the highest classification accuracy. The k-nearest neighbor classifier is employed in the experiments to evaluate the classification performance on the IEEE 39-bus dataset.
Євроденс як стильовий напрям української пісенної естради 1990-х років
Authors: ZOSIM Olga , PODUNAI Yana
Published: April 2023

У роботі окреслено специфічні риси стилю «євроденс» та охарактеризовано доробок українських виконавців, що працювали у цьому стилі, в контексті розвитку української пісенної естради 1990-х рр. Методологія дослідження передбачала застосування історико-культурного, порівняльного та музично-аналітичного методів, які дали можливість визначити специфічні риси європейських пісенних шлягерів, написаних у стилі «євроденс», та показати особливості його рецепції українськими естрадними виконавцями 1990-х рр. Євроденс як музичний стиль мав коротку історію (1992-1995 рр.), проте велика кількість шлягерів засвідчила його значущість для розвитку європейської популярної музики. Соціокультурне підґрунтя євроденсу – європейські цінності толерантності та поваги до кожної людини, основний меседж – заклик до єдності й любові. Євроденс виникає на стику електронної та поп-музики: актуальний саунд ейсид-хаусу стає стильовим підґрунтям комерційного пісенного хіта 1990-х рр. Розвиток українського євроденсу припадає на другу половину 1990-х рр. Серед численних українських виконавців, що працювали у стилі «євроденс», гурти «Турбо-Техно-Саунд», «Фантом-2», «Аква Віта» зробили найбільший внесок у розвиток та стильове оновлення української пісенної естради. Український євроденс на початковому етапі відзначався інтелектуалізмом («Турбо-Техно-Саунд», «Фантом-2»), проте інформаційне перевантаження текстів негативно позначилося на музичній драматургії пісень, що стало перешкодою у створенні повноцінних євроденс-хітів. Класичні зразки євроденс-стилю («Аква Віта») відзначалися стрункістю музичної будови та мали усі риси комерційного шлягеру завдяки відмові від надмірного інтелектуалізму й орієнтації на базові принципи побудови євроденс-композицій. Українські євроденс-хіти з’явилися вже у період стильової переорієнтації європейської музики, а тому євроденс в українській естраді не встиг цілком розкрити свій потенціал. І хоча українські виконавці в силу багатьох причин не могли претендувати на місця у європейських хіт-парадах, євроденс розпочав символічний рух України в європейський культурний простір, а, отже, став підґрунтям її майбутньої культурної євроінтеграції.
What the history of “poverty thinking” means for future “development”
Authors:   Stockholm Environment Institute, Osborne Matthew , Kemp-Benedict Eric , Betancur Juan
Published: April 2023

This essay provides a description of poverty thinking and development over the past two centuries, and positions the current frontiers in approaches and understandings against this historical background.
Antiviral mechanisms targeting regulatory genes Tat and Rev to defeat latent HIV-1 infected T cells: a literature review
Authors: Sintya Erly , Wedari Ni Luh Putu Harta , Pranata I Wayan Adi , Budayanti Ni Nyoman Sri
Published: April 2023

Antiviral drug therapies have been utilized to prevent disease progression in patients positive HIV-1. Various research has been conducted to investigate and develop a potential functional therapy to suppress HIV-1 replication and cure latent HIV-1 in the absence of drugs. Approaches that have been well studied are the anti-HIV-1 which targets RNAs, proteins, or peptides expressed by HIV-1 resistant cells, which can be transplanted to the patients. RNA interference in the form of small RNA has been proven as a promising therapy to prevent HIV-1 replication. It is utilized for therapy using cell transplantation and various gene combinations in clinical trials. However, many studies have been failed to show a successful eradication of latently HIV-1 infected T cells. It is happened due to the virus's ability to escape from antiviral therapies. However, this can be overcome by using a combination of ARTs. On the other hand, genetic editing has been intensively studied since it can cure various diseases caused by genetic or pathogen infections, including HIV type 1. The previous studies have designed gRNA bind to protein Cas type 9 targeting HIV functional genes, Tat and Rev sequences. Various recombination has been introduced to CRISPR-based gene editing to increase the binding affinity and efficiency of Cas9 to target Tat and Rev proteins of their exons. The best approach for the Cas9 targeted Tat and Rev is by utilizing more than one guide RNA. However, Subsequent studies are needed to confirm the ability of Cas9 with various guide RNAs to inhibit virus activation and replication in latent HIV-1. This review aims to describe the mechanisms, advantages, and disadvantages of antiviral therapies that target Tat and Rev as regulatory genes to eradicate latent HIV-1 infected T cells.
The current trend for prosthetic joint infection diagnosis from culture to molecular: a literature review
Authors: Natasha Augustine , Wahid Mardiastuti , Sudarmono Pratiwi
Published: April 2023

Pathogen identification in prosthetic joint infection is necessary to achieve optimal patient management. The specimens for diagnosis of prosthetic joint infection could be the synovial fluid, the tissue obtained intraoperatively, and the biofilm from the implanted prosthesis. Because of the low sensitivity of the conventional specimen culture method, the preanalytic treatment of the specimen was widely studied to increase the yield of detection. This review aimed to describe the current specimen processing methods used in the clinical setting to increase the pathogen detection rate. A blood culture bottle, tissue homogenization, and explanted prosthesis sonication were the most studied methods with a good result. Molecular methods were also developed to reduce the time of pathogen detection. MALDI-TOF was studied to reduce identification time after a positive culture. Other molecular methods such as polymerase chain reaction and next-generation sequencing were studied to omit the culture step and reduce detection time. However, the impracticality and the inconsistent sensitivity of certain specimens from the molecular methods limit its application in the clinical setting. Specimen culture remains as a crucial step in the current prosthetic joint infection, with the improvement of the molecular methods toward a better prosthetic joint infection diagnosis.
Antifungal susceptibility profile of Candida spp. causing candidemia in an Indonesian tertiary hospital
Authors: Wulandari Andini , Hapsari Rebriarina , Mujahidah  , Sari Desvita , Puspitasari Iva , Pramukarso Dodik Tugasworo
Published: April 2023

Introduction: Invasive candidiasis has emerged as a significant public health problem in recent years, and candidemia is the most common form. Identification of the Candida species is important since some Candida species showed an increasing trend of resistance to commonly used antifungal agents. This study was conducted to describe primary demographic data and the distribution of Candida species along with their antifungal susceptibility profiles among patients with candidemia.
Methods: We conducted a retrospective descriptive study on patients with candidemia and their Candida species identification and antifungal susceptibility testing (ID&AST) results at Dr. Kariadi Hospital, Indonesia, from January 2017 to December 2020. Identification and antifungal susceptibility testing of Candida species during these 4 years were determined using the Vitek-2 system. After collecting the data, it was analyzed by using SPSS 25.sav. The data was analyzed distributively, and was presented by table and barchart.
Result: A total of 85 Candida species were isolated from 74 patients. Infant age (58.10%) and intensive care (64.86%) patients contributed to most of the candidemia cases. The three most common Candida species isolated during the study period were C. parapsilosis (36.9%), C. tropicalis (25%), and C. albicans (25%). Among all Candida isolates, 98.9% were susceptible to Fluconazole and Voriconazole, 99% were susceptible to Caspofungin, Micafungin, and Flucytosine, 95.7 % were susceptible to Amphotericin B. Echinocandin resistance emerged in 2020 from a C. glabrata isolate.
Conclusion: The present study, conducted in a tertiary care Indonesian hospital, showed the predominance of non-albicans Candida with favorable antifungal susceptibility profiles.
A rare finding of Burkholderia pseudomallei isolate from neck abscess, 4 years after the last report in Makassar: a case report
Authors: Ilhamjaya Andi Meutiah , Muhammad Munawir , Ramadhan Ahmad Rahmat , Sjahril Rizalinda
Published: April 2023

Introduction: Burkholderia pseudomallei is the causative agent of melioidosis, known as Whitmore's disease, a tropical disease in humans. The bacteria can infect humans or animals, mostly found in contaminated water and soil. It spreads by direct contact with contaminated sources, inhalation or ingestion of contaminated dust or water droplets, or contact with soil through skin abrasions. Melioidosis is highly endemic in Southeast Asia and Northern Australia but rare in Makassar.
Case description: A 44-year-old woman shows a red mass on the right neck, reddish, palpable, ±6x5x4mm in size, and is soft in consistency and has a cystic impression. Direct gram showed purulent mixed with blood. 24 hours after incubation under aerobic conditions, grew small colonies, smooth, cream in color, non-lactose fermenter on Mac Conkey agar. Indirect gram shows a small, gram-negative rod (safety pins appearance). The colonies were positive in the catalase and oxidase test, with citrate and urease test was negative. Burkholderia pseudomallei was identified by Vitek2 with 97% Probability. It was susceptible to doxycycline, ceftazidime, and Trimethoprim/Sulfamethoxazole.
Conclusion: This is a rare finding in a clinical isolate found in Makassar. A newly emerged case, four years after the last report in Makassar. This is still a challenge to public health problems in Makassar, must be reported consistently and never lost to follow up to get proper treatment.
Complication of tunneled dialysis catheter of chronic ulcer in the site of vascular access entry leading to suspected squamous cell carcinoma (SCC): a case report
Authors: Ramadhani Febriana Rizky , Herdianti A , Intan RE , Sabrina AN , Putro GS , Septira E
Published: April 2023

Introduction: Catheter-related infection (CRI) is one of the most common vascular access complications in dialysis catheter-related procedures. However, repeated chronic infected ulcer that leads to suspected malignancy in a tunneled dialysis catheter (TDC) insertion site and its risk factor have not been reported.
Case description: A 37 years-old woman presented with a chronic exudative ulcer in the right breast at the entry site of a tunneled dialysis catheter. The past medical history included type 2 diabetes mellitus, chronic kidney disease, hepatitis C, and obesity. The patient had routine hemodialysis with TDC for the last 2 years and had changed the TDC access 3 times due to recurrent CRI. At first, the lesion appeared as a small pustule and enlarged recurrently. Later, the lesion progressed into an 82x80 mm raised crateriform exudative ulcer with a raw surface similar to Marjolin’s ulcer squamous cell carcinoma. The patient was referred to oncology due to limited facilities in our hospital.
Conclusion: CRI is one of the most common long-term complications of TDC. In out of the case, this led to chronic infection and change in TDC, chronic inflammation then became Marjolin’s Ulcer. Risk factors for suspected SCC in our patient were immunosuppressive state from diabetes, hepatitis C, CKD, and chronic inflammation from a repeated chronic infected ulcer. SCC can be considered a long-term complication of TDC. Early prevention of CRI and risk factor controlling should be considered to prevent such complications.
Dual antiplatelet therapy of clopidogrel plus aspirin versus aspirin monotherapy in patients with Coronary Artery Disease (CAD): a systematic review and meta-analysis
Authors: Hamzah Haidar Ali , Theodorus
Published: April 2023

Background: Aspirin is the most commonly used for treatment in patients with coronary artery disease (CAD). However, there are many evidences from several trials suggested that dual antiplatelet therapy (DAPT) might exhibit a better outcome and more effective than aspirin monotherapy. Thus, we aimed to assess the effect of DAPT versus aspirin monotherapy in patients with CAD.
Methods: Electronic databases were performed in PubMed, EMBASE, and Cohrane from Januari 2005 until March 2021. We searched for randomized control trials comparing DAPT versus aspirin monotherapy in patients with CAD. Pooled effects estimates were reported as an odds ratio (OR) with 95% confidence intervals (CI) and calculated using random effects model. RevMan 5.4 software was used for data analysis.
Results: Five randomized control trials with a total of 8,203 participants met the inclusion critera. DAPT was found to have an association in reducing the risk of major adverse cardiovascular events (OR 0.72; 95% CI 0.57-0.90; p = 0.003; I2 = 17%) and death events (OR 0.62; 95% CI 0.49-0.79; p < 0.0001; I2 = 0%)  compared with aspirin monotherapy. Yet, there were no significant difference in myocardial infarction events (OR 0.78; 95% CI 0.57-1.07; p = 0.13; I2 = 28%) and bleeding events (OR 1.65; 95% CI 0.97-2.81; p = 0.06; I2 = 0%) between two groups.
Conclusions: DAPT treatment has a significant effect in reducing the risk of major cardiovascular and death events without a significant effect in myocardial infarction and bleeding events compared with aspirin monotherapy.
Iatrogenic pseudoaneurysm as a complication of hemodialysis vascular access: a descriptive study
Authors: Sulistyaningsih Ni Kadek , Lie Zanella Yolanda , Limanto Danang Himawan
Published: April 2023

Introduction: Iatrogenic pseudoaneurysm (PSA) in hemodialysis vascular access puncture site is the most common complication in a patient with ERSD, which needs urgent surgical intervention. This research explained the patients’ characteristics with pseudoaneurysm in vascular access that underwent surgical intervention immediately.
Methods: Retrospectively, it reported cases of pseudoaneurysm that underwent immediate surgical intervention in an operating theatre in the emergency department of RS Dr. Soetomo Surabaya.
Result: Twenty-one patients, whose age range from 26-to 64 years old (mean 46.57 + 12.14 years), have undergone immediate surgical and vascular intervention in an operating theater in the emergency department of RS Dr. Soetomo from 2017 until March 2021. The site of pseudoaneurysm varies from cubiti (90.4%), with signs and symptoms of impending rupture (57.1%), rupture (28.6%), and infected pseudoaneurysm (14.3%). Surgical management such as arterial repair was conducted in 90.4% of cases, and two patients (9.6%) unfortunately underwent takedown AVF. It was found from all 21 cases that nine cases didn’t have vascular access as recommended, leading to repetitive puncture in the same puncture site.
Conclusion: Iatrogenic Pseudoaneurysm in ESRD patients on regular hemodialysis is the most common complication that has been treated. The medical staff’s knowledge about recognition and prevention is a crucial factor in controlling this complication
Distal femur aneurysmal bone cyst treated with two stages of surgery in the pandemic COVID-19 by excision-skeletal traction and endoprosthesis replacement: a case report
Authors: Idulhaq Mujaddid , Gardjito Fajar Baskoro , Saputra Rhyan Darma , Hakim Fikar Arsyad , Saddalqous
Published: April 2023

Introduction: An aneurysmal bone cyst (ABC) is benign but has a progressive nature that can cause severe problems if it occurs close to joints such as the knee. The ultimate goal of treatment is to remove the tumor, maintain limb function, and prevent a recurrence. Local therapy is still better than tumor resection. This study aims to describe a rare case about distal femur ABC treated with two stages of surgery in the pandemic COVID-19 by excision-skeletal traction and endoprosthesis replacement.
Case description: A 31-year-old woman presented with a lump on the right knee. The patient has complained of limping. Open biopsy was performed, and the patient was confirmed to have ABC on the distal of her right femur. The patient had a leg length discrepancy of 8 cm. We decided to do skeletal traction first. One week after the skeletal traction, the patient undergoes endoprosthesis replacement.
Conclusion: The management of wide excision of the tumor requires special postoperative attention. This is because aggressive measures can reduce the recurrence rate of tumors, but large reconstructions are also needed to maintain joint function.
Vesicocutaneous fistula following inguinoscrotal hernia repair: a case report
Authors: Kurniawan Aninditho Dimas , Dahril
Published: April 2023

Introduction: A vesicocutaneous fistula (VCF) represents an abnormal association between the bladder and the skin's surface. VCF mostly present as a complication of the diseases and treatments. Maceration, difficulty in treating the infection, moisture-associated skin damage, malodor, inconveniences, and physical disability were the sign and symptoms of VCF besides the visible urine leakage. A vesicocutaneous fistula should be treated adequately when recognized due to it may give bothersome complaints, social effects, and a possibility of recurrence to the patients. Proper surgical interventions are imperative because VCF leads to life-threatening complications such as cancer and sepsis. In this case, we report a case of vesicocutaneous fistula following inguinoscrotal hernia surgical repair in a 63-years-old man in order to provide an overview of the management of patients in similar cases.
Case Description A 63-years-old man with a history of strangulated hernia and underwent exploratory laparotomy and ileostomy two weeks ago. Intermittent small amounts of urine discharge from the left groin was developed eleven days after the operation. The vital sign was normal, with a physical examination revealed a wet postoperative wound at the left groin. Mild tenderness over the suprapubic area. The hematology tests were normal. Cystography with contrast revealed the contrast appears to fill the bladder, and there is neither extravasation of contrast from the bladder to the distal end of the fistulous tract. The result was confirmed as the multiple diverticles within vesica urinaria. Incision of VCF was performed, and the bladder was closed in two layers with 3-0 Chromic for the mucosa and running polyglycolic acid (vicryl) 2-0 for the muscular.
Conclusion: Laparotomy should be performed with care, and the surgeon must be aware of possible organ trauma. In our patient VCF was treated by suturing the fistula after drainage.
Histopathological overview of wound healing process in white rats (Rattus norvegicus) using Chromolaena odorata leaf jelly extract
Authors: Yudhika Indra , Jailani Muhammad , Dasrul
Published: April 2023

Background: Various efforts have been made to accelerate the wound healing process in white rats, one of which is using Chromolaena odorata. The leaves contain tannins, phenols, flavonoids, saponins, and steroids, which accelerate the wound healing process. The purpose of this study was to determine the effect of Chromolaena odorata leaf jelly extract on the wound healing process in the inflammatory and proliferative phases in white rats microscopically (Rattus norvegicus). 
Methods: A total of 27 healthy adult male white rats aged 3-4 months old were given open wounds on the back measuring 2x2 cm. The rats were then divided into four groups, a group administered with jelly without Chromolaena odorata leaf jelly extract (P0) and groups administered with Chromolaena odorata leaf jelly extract with concentrations of 10% (P1) and 30% (P2), respectively. Chromolaena odorata leaf jelly extracts were given daily by rubbing them on the wound surfaces. Skin biopsies were collected and evaluated histopathologically on days 3, 7, and 14 post-treatment. The histological assessment of wound healing was based on epithelialization and collagen density using Nagaoka criteria. The data were analyzed by analysis of variance (ANOVA) and continued with the Duncan test.
Results: The Duncan test results showed that the mean score of the degree of epithelialization and collagen density of wound tissue on days 7 and 14 was significantly higher in the P2 group compared to the P0 and P1 treatments, while the P1 group was not significantly different from P0. 
Conclusions: In conclusion, the administration of Chromolaena odorata leaf jelly extract could accelerate the degree of epithelialization and collagen density in the wound healing process of the inflammatory and proliferative phases of white rats (Rattus novergicus).
The effect of oral glucose administration before surgery based on Enhanced Recovery After Surgery (ERAS) protocol on preventing insulin resistance and patient's quality of life
Authors: Jufriady Ismy  , Wisesa Indra , Muhammad Yusuf  , Iflan Naufal  , Imam Hidayat  , Muslim
Published: April 2023

Introduction Preoperative oral glucose administration is part of the ERAS protocol, which is still not implemented worldwide. This study aims to determine the effect of preoperative oral glucose administration based on the ERAS protocol on the patient's quality of life and insulin resistance.
Method This study is a quantitative quasi-experimental study (post-test with control group) involving patients undergoing surgery using general anesthesia at dr. Zainoel Abidin Banda Aceh from January 2021 to April 2021. The intervention was carried out on patients who were about to undergo surgery divided into two groups: the group receiving and the group not receiving 50 grams of oral glucose 2 hours before surgery according to the ERAS protocol. The data obtained were processed using Chi Square statistical test, Mann- Whitney, and unpaired T-test to assess patients' quality of life and insulin resistance.
Result A total of 48 patients (24 treatment group and 24 control group patients) were involved in the study. There were significant mean differences in all quality of life indicators between the group receiving and the group not receiving oral glucose with a significance value of p<0.05. There is a relationship between oral glucose administration and prevention of insulin resistance with a significance value of p<0.05.
Conclusion: There is a relationship between preoperative oral glucose administration on quality of life and postoperative insulin resistance according to the ERAS protocol.
Impact of Covid-19 pandemic on urology practice in tertiary hospital in Banda Aceh, Indonesia: a descriptive study
Authors: Qosasi Kiagus Ferry Fabian , Dahril
Published: April 2023

ABSTRACT
Introduction: Coronavirus disease-19 (Covid-19) pandemic has brought a dramatic change in health care worldwide, including urologic care. Patients requiring non-covid care are encouraged to avoid hospital visits and postpone elective surgeries to reduce the risk of transmission and anticipate a surge in Covid-19 patients. This study aims to describe Covid-19-related changes in urologic care in tertiary hospitals in Banda Aceh, Indonesia. 
Methods: This is a descriptive study in dr. Zainoel Abidin Regional General Hospital, Banda Aceh. The number of outpatients’ visits and urologic surgeries performed in March – October 2020 were recorded and compared to the numbers within the same period in 2019. The most common surgery performed during a pandemic is determined. 
Results: The number of outpatient visits in March – October 2020 was 2,595 visits, while in 2019 was 3,886. There was a 54.29% decrease in March-May 2020 and a 17.76% decrease in June – October 2020. The number of surgeries carried out in March – October 2020 was 381, while in 2019 was 264. The most common surgeries performed during the pandemic is stones removal (n = 119) and reconstructive surgeries (n = 104). 
Conclusion: There were decreases in both number of outpatients’ visits and surgeries performed during the Covid-19 pandemic. The most common urologic surgery carried out during the pandemic were stones removal and reconstructive surgeries.
The role of ROS1 mutation in non-small cell lung cancer
Authors: Novita Andayani  , Basti Handoko  , Murtaza
Published: April 2023

Lung cancer is a malignancy of the lung organs consisting of primary lung cancer originating from lung epithelial cells and metastatic lung cancer originating from other organ cancers that spread. In lung cancer, the vast of recent studies investigated the role of molecular alterations in patients. Molecular characterizations of lung cancer give further information in order to better diagnosis, prognostic, and therapeutic implications in patients. c-ROS oncogene 1 (ROS 1) is naturally expressed by healthy and normal cells arranged in human chromosomes. The role of ROS1 in its normal development is not fully understood. Point of view in oncology ROS1 expressed normally is referred to as inactive ROS1. Mutated ROS1 due to fusion with a specific gene produces tyrosine kinase receptors on the surface of the cell that has the advantage of sending signals into the cells to induce growth factors and proliferation of ROS1. Although the prevalence of ROS1 rearrangement was low, the parallel with Non-Small Cell of Lung Cancer (NSCLC), the most dominant lung cancer, indicating the number of ROS1 mutation patients also increased. The challenge of diagnosing ROS1 mutation by Immunohistochemical (IHC) ROS1 is only a screening method and confirmed by fluorescence in situ hybridization (FISH) examination. The appropriate therapy regimen for positive ROS1 mutation will increase the survival rate in lung cancer patients.
Profile of Arthrogryposis Multiplex Congenita (AMC) patients on surgery treatment at single centered study in orthopaedic hospital and a brief review
Authors: Kumara Hendra Cahya , Satriadi Anung Budi , Saddalqous
Published: April 2023

Introduction: Arthrogryposis multiplex congenita (AMC) is a complex abnormal condition characterized by multiple congenital contractures in the body's joints. Although this condition is not progressive, if not treated properly, it will increase the degree of disability in children. There are two types of AMC. The most common type of AMC is amyoplasia. The second type is distal arthrogryposis (DA), a genetically inherited type characterized by congenital contractures in multiple joints and no neurologic or muscular abnormalities. The incidence of AMC 1:3000 births with clubfeet and congenital hip dislocation is the most common. In this retrospective study, the authors described the profile of AMC patients who underwent surgery at our center with the approach and management.
Method: The study design was a descriptive retrospective. The population of this study is all AMC patients who underwent surgery at the orthopedic hospital of Prof. Soeharso Surakarta, Indonesia. We used the total sampling technique who underwent surgery in the 2018-2021 period.
Result: In this study, we got eleven AMC patients who underwent surgery. Distribution based on sex found six boys and five girls. Half of the patients underwent surgery under the age of three years, while the other half underwent surgery after the age of five. The presence of patients who are consulted at an older age indicates a lack of public literacy about the abnormal condition of AMC or a lack of concern for the condition. Almost all AMC patients who undergo surgery are in the lower extremities.
Conclusion: Rehabilitation plays a very important role in improving the quality of life for AMC patients. A multidisciplinary approach is needed in the treatment of AMC patients. Surgery is performed if stretching and external support splinting/casting cannot achieve functional ROM and repair the deformity.
Sinonasal Inverted Papilloma Extirpation by Endoscopic Approach: a Case Report
Authors: Teuku Husni T.R  , Mulya Ridha Chaharsyah
Published: April 2023

Introduction :Inverted papilloma is a benign tumor that generally arises from the lateral wall of the nasal cavity and mostly grows on the middle meatus.The incidence is rarely found in the ear, throat, nose, throat, head and neck, around 0.5% -4% of all nasal and paranasal sinus tumors.The etiology of inverted papilloma remains unknown.Clinical features of inverted papilloma are unilateral nasal obstruction, rhinorrhea, epistaxis, anosmia, tinnitus and other symptoms.The diagnostic examination are histopathological examinations, CT scans and MRI.Histopathology is the gold standard in diagnosing of inverted papilloma.Management of inverted papilloma is carried out with surgical approach including lateral rhinotomy, maxillectomy, degloving, and non-invasive surgery via endoscopy depend to the krouse classification.
Case description : A 44 year-old female patient diagnosed with inverted papilloma was reported.The patient complained of progressiveright nasal obstructionappeared two years ago that turn into total obstruction and rhinorrhea in the last 6 months.A biopsy was done with the result of inverted papilloma. CT scan of the paranasal sinuses showed a mass filling the right nasal cavity, right maxillary sinus and right ethmoid sinus. Patientwas diagnosed with sinonasalinverted papilloma with krouse 2 classificationbased on clinical examination, radiological finding and preoperative endoscopy. Patient was treated with sinonasal inverted papiloma extirpation via endoscopic approach.
Conclusion: Inverted papilloma is a benign tumor of the nasal and paranasal sinuses, and biopsy is the gold standard for diagnostic tests. At the same time, the main treatment is done by surgical approachdepend on the krouse classification.
Conservative management of penile fracture: a case report
Authors: Syaheza Ahlan , Munandar Rudi Haris , Dahril
Published: April 2023

Background: One of the uncommon emergencies in urology is a penile fracture. Due to blunt trauma to the erect penis, the tunica albuginea of one or both corpus cavernosum was disrupted, a rare kind of urologic damage. Corpus spongiosum or urethral rupture and dorsal nerve and vascular injury may also be present. Here, we describe a penile fracture case that was successfully treated conservatively at Zainoel Abidin Hospital.
Case report: A 38-year-old male who had been having sex an hour before and had meatal bleeding, a history of cracking noises, and rapid detumescence presented to the emergency room at Zainoel Abidin Hospital. The patient also had pain when urinating. Physical examination revealed an enlarged penis and meatal hemorrhage but no ecchymosis or eggplant-like appearance. No bladder is full. The Foley catheter was put in. on ultrasonography of the penile. The hematoma was present in the corpus cavernous and spongiosum, and the urethra lumen was uneven. A pendulous urethral rip about 5 mm in size was found during urethroscopy. After 2 days of observation, the erectile function returned without pain or menstrual blood. After two days of conservative therapy, the patient was discharged from the hospital.
Conclusion: Conservative treatment of the penile fracture is still an option based on clinical findings in cases.
Laboratory diagnosis of COVID-19 cases from nasal and oropharyngeal swab specimens
Authors: Renatha Nainggolan
Published: April 2023

Introduction: Indonesia first reported Covid-19 on March 2, 2020, which continued to increase and spread rapidly throughout Indonesia. WHO recommends molecular examinations for patients with suspected COVID-19 through molecular detection method or NAAT (Nucleic Acid Amplification Test), including Real Time-Polymerase Chain Reaction (RT-PCR) tests. This study aimed to describe the profile of RT-PCR test services on nasal and oropharyngeal swab specimens from patients treated at Dr. Pirngadi Hospital Medan and patients of primary health care (Puskesmas) or other hospitals referred for RT-PCR examination at the Laboratory of Dr. Pirngadi Hospital.
Method: This was a retrospective, descriptive study using secondary data from medical records from August 2020 to July 2021. Using consecutive sampling, the study sample was all suspected and confirmed COVID-19 specimens collected at Dr. Pirngadi Hospital, Medan. All collected data were processed and analyzed using IBM SPSS version 20.0.
Result: There were 7495 specimens of COVID-19 from Dr. Pirngadi Hospital from August 2020 to July 2021, of which 1264 (17%) were confirmed positive, and 6231 (83%) had negative results. Meanwhile, 12.274 specimens were obtained from primary health care or other hospitals, of which 2602 (2%) samples were confirmed positive, and 9672 (98%) had negative results. Based on sex, 884 men (44%) and 1108 women (56%) had confirmed COVID-19 cases.
Conclusion: From August 2020 to July 2021, this study found 17%  and 2% of confirmed COVID-19 cases at Dr. Pirngadi Hospital and primary health care or other hospitals, respectively. COVID-19-confirmed issues were more common in women.
Tétanos generalizado en un adulto: reporte de un caso
Authors: Carrión Salinas Evelyn del Cisne , Jáuregui Solórzano José Miguel , Paucar Aguayo Paola , Rojas Vivanco Ximena , Córdova Villacís Luisa , Alemán Espinoza Washington
Published: April 2023

El tétanos es una enfermedad infecciosa causada por las esporas de la bacteria Clostridium tetani que afecta el sistema nervioso. La inmunización contra esta enfermedad ha permitido reducir lamorbilidad y la mortalidad, por lo que es importante favorecer los programas de vacunación en todos los grupos de edad. Los pocos casos reportados en los años recientes en Ecuador pertenecen a pacientes sin previa vacunación contra el tétanos. Se presenta un paciente de 50 años con antecedente de herida avulsiva del cuero cabelludo que desarrolla cinco días después presentación clásica del tétanos con espasticidad generalizada y trismus. El diagnósticoen este caso se dificulta por una infección meníngea concomitante, siendo este uno de los principales diagnósticos diferenciales. Una vez establecidos los diagnósticos, se inició el tratamiento antibiótico y la inmunización recomendada por las guías actuales con evolución favorable del paciente.
Caracterización del perfil microbiológico en pacientes con diagnóstico de infecciones nosocomiales en un centro único
Authors: Felizzola Bohórquez Yira Johanna , Silva Cevallos Danny Fernando
Published: April 2023

Introducción: Las infecciones nosocomiales constituyen un creciente problema de salud pública que se relaciona a la prescripción de antimicrobianos y la resistencia bacteriana; tiene impacto social y económico, ya que aumentan los días de hospitalización y costos de atención. El objetivo es analizar el perfil microbiológico, la resistencia bacteriana y el uso de antibióticos en pacientes con infecciones nosocomiales en Clínica Guayaquil.
Materiales y Métodos: Estudio retrospectivo, descriptivo y analítico del perfil microbiológico que incluyó a los pacientes mayores de 18 años hospitalizados desde julio a diciembre de 2020, con diagnóstico de infecciones asociadas a atención en salud. Se analizaron los perfiles de resistencia y susceptibilidad de los microorganismos.
Resultados: 236 pacientes tuvieron cultivos positivos, edad media 56 años, 70% masculino, 25 días de hospitalización, 15 días de antibioticoterapia, 64% presentaron comorbilidades, 82% tenía hospitalizaciones previas. La mayoría de aislamientos correspondieron a vías respiratorias (34%). El 69% de los microorganismos aislados fueron gramnegativos: Klebsiella pneumoniae con mecanismos de resistencia a betalactamasas de espectro extendido y productoras de carbapenemasas. Se encontró una asociación de riesgo estadísticamente significativa entre losdías de hospitalización, antibioticoterapia previa y las infecciones nosocomiales resistentes.
Conclusión: Las infecciones hospitalarias representaron el 6% de los pacientes analizados, se aislaron predominantemente bacterias multirresistentes: K. pneumoniae BLEE y KPC, E. coli BLEE, S. aureus meticilinoresistente, por lo que deberían mejorarse la cobertura antimicrobiana empírica en los pacientes con diagnóstico de infección nosocomial; y además, tomar en cuenta factores como sexo masculino, hospitalizaciones previas, y antibioticoterapia previa.
Sites web et agentivité d’entités circulantes
Authors: LE BÉCHEC Mariannig
Published: April 2023

Ce chapitre décrypte les territoires numériques de marques à partir des entités circulantes entre les sites web, considérés comme éléments constitutifs des dynamiques symboliques portées par les identités numériques des organisations. A travers différents exemples, il montre à la fois la transposabilité et l’agentivité de ces entités circulantes, saisis en tant que signes.
Analyses des stratégies de communication numérique à destination des proches aidants
Authors: ROUQUETTE Sébastien , CHAUZAL-LARGUIER Christelle
Published: April 2023

Ce chapitre interroge le rôle des sites web d’associations et d’organisme lucratifs à destination des proches aidants : ceux-ci restent-ils pertinents au regard de stratégies de communication numérique relayées par les médias sociaux ? Pour répondre à cette question, les auteurs s’appuient sur un dispositif méthodologique mixte mettant en évidence les atouts communicationnels non substituables des sites web.
Communication d’associations en ligne et stratégies discursives : étude de cas
Authors: OVOUNDAGA Marcy Delsione
Published: April 2023

Ce chapitre étudie la communication des associations à partir de leurs stratégies discursives en ligne, à partir d’un corpus de publications et commentaires Facebook issu de deux associations, la Chaîne de l’espoir et Action contre la faim. Il met en évidences des stratégies de marketing social s’appuyant sur des stratégies discursives valorisant les dimensions argumentative et empathique.
Ancrages culturels et politiques de la communication environnementale sur le Web
Authors: MELLOT Sandra , HOANG Anh Ngoc , PRODHOMME Magali , THEVIOT Anaïs
Published: April 2023

Ce chapitre étudie la communication environnementale en ligne d’organisations non gouvernementales et de collectifs. A partir d’une analyse sémiotique d’un corpus de sites web et de clips vidéo, les auteurs révèlent des registres d’éthos différenciés (éthos de l’action, de la volonté, de la justice, de la croyance) et l’émergence d’une nouvelle homonoïa écologique.
Principes, chaîne instrumentale et quantification en IRM
Authors: SAINT-JALMES Hervé , RATINEY Hélène , BEUF Olivier
Published: April 2023

Ce chapitre introductif est dévolu à une description succincte des principes physiques de l’IRM et des composants principaux d’un appareil d’IRM et particulièrement ceux associés à la création des champs magnétiques ainsi qu’à la mesure du signal. Les solutions technologiques actuellement mises en œuvre sont décrites avant de conclure sur une vue générale des approches quantitatives en IRM largement abordées dans cet ouvrage.