bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilidad de los estudios en busca de autoinmunidad en pacientes con urticaria crónica espontánea
Authors: Rojo-Gutiérrez María Isabel , Flores-Ruvalcaba Christian Nataly , Mellado-Ábrego Jaime , Castillo-Narváez Gloria , Ramírez-Rojo Danika Pammela
Published: January 2021

Antecedentes: la urticaria crónica espontánea es una enfermedad común en los adultos, sobre todo entre las mujeres; esta entidad con frecuencia está relacionada con padecimientos autoinmunitarios.Objetivo: evaluar, mediante estudios de laboratorio, si los pacientes con urticaria crónica espontánea tuvieron signos de autoinmunidad.Material y método: estudio transversal de 35 pacientes del área de Alergia e Inmunología del Hospital Juárez de México, diagnosticados con urticaria crónica espontánea. Se les realizó biometría hemática completa, anticuerpos antitiroideos (antiperoxidasa y tiroglobulina), anticuerpos antinucleares, factor reumatoide, anticoagulante lúpico, células LE, prueba cutánea de suero autólogo (Autologus Serum Skin Test, ASST), complemento (C3 y C4); como estudios adicionales se les realizó prueba de Helicobacter pylori, perfil tiroideo (T3,T4, TSH) y dímero D.Resultados: evaluamos 35 pacientes adultos, 27 eran mujeres. La prueba ASST fue positiva en cuatro pacientes, los anticuerpos antinucleares fueron negativos en todos los casos, pero los anticuerpos antitiroideos resultaron positivos en cuatro pacientes. Las células LE, anticoagulante lúpico, complemento, dímero D, perfil tiroideo y Helicobacter pylori fueron normales o negativos y el factor reumatoide fue positivo en un paciente. Todos los pacientes antitiroideos positivos eran mujeres y de ellas, 26 tuvieron ASST negativa. La correlación entre ASST y AAT no fue significativa.Conclusiones: en nuestro estudio, la mayoría de los pacientes con urticaria crónica espontánea eran mujeres y sólo cuatro tuvieron la prueba ASST positiva, pero esto no se correlaciona con existencia de anticuerpos antitiroideos. La mayor parte de los estudios realizados resultaron normales, por lo que sugerimos no hacer estudios de laboratorio innecesarios en esta afección.
Alergia a las proteínas del huevo en edad pediátrica
Authors: Góngora-Meléndez Marco Antonio , Magaña-Cobos Armando , Montiel-Herrera Juan Manuel , Pantoja-Minguela Cinthya Lorena , Pineda-Maldonado Mario Luis , Piñeyro-Beltrán Eduardo Enrique
Published: January 2021

La prevalencia de alergia alimentaria se incrementó en los últimos años: afecta de 15 a 20% de la población infantil; específicamente, la alergia al huevo afecta de 0.5 a 2% de población pediátrica. La mayor parte de las reacciones alérgicas al huevo son tipo I; es decir, son mediadas por anticuerpos de tipo IgE dirigidos contra proteínas contenidas en este alimento. Se ha identificado cinco alergenos mayores: ovomucoide (Gal d1), ovoalbúmina (Gal d2), ovotransferrina (Gal d3), lisozima (Gal d4) y albúmina (Gal d5). La mayor concentración de proteínas alergénicas están en la clara del huevo (Gal d1-4), mientras que en la yema de huevo sólo encontramos una (Gal d5). La proteína ovomucoide, que contiene la clara, es resistente al calor y a las enzimas digestivas; se considera la proteína con mayor poder alergénico y la ovoalbúmina es la proteína más abundante. El diagnóstico clínico requiere una detallada anamnesis. Por lo general, se realiza cualquiera de las pruebas (cutáneas o IgE específica) como primera opción. Las pruebas cutáneas son una prueba rápida y útil para determinar la existencia de anticuerpos IgE específicos al huevo. La IgE específica al huevo puede medirse cuantitativamente mediante estudios estandarizados de IgE in vitro. En conjunto con una buena historia clínica, se utilizan para apoyar el diagnóstico clínico. El reto oral estandarizado, doble ciego, controlado con placebo, aún es el patrón de referencia para el diagnóstico de alergia alimentaria. La identificación y eliminación en la dieta de la proteína de huevo responsable de las reacciones alérgicas es el tratamiento primario y el único validado contra la alergia a este alimento, pero se necesitan más estudios para establecer los protocolos para cada alergeno específico del huevo, antes de que la inmunoterapia oral se convierta en una práctica rutinaria.
Puntos clave en el tratamiento de la dermatitis en Latinoamérica. El consenso SLAAI
Authors: Sánchez Jorge , Páez Bruno , Macías-Weinmann Alejandra , De Falco Alicia
Published: January 2021

La incidencia de la dermatitis atópica en Latinoamérica, al igual que en otras regiones del mundo, se incrementó en los últimos años. El Consenso SLAAI se basa en una búsqueda sistemática de artículos relacionados con la dermatitis, en cuanto a su fisiopatología, tratamiento y repercusión en Latinoamérica; en el consenso se revisó la metodología Delphi (Revista Alergia México 2014;61:178-211). En este artículo resaltamos los puntos clave del consenso y las consideraciones particulares en Latinoamérica.
El protocolo de investigación. Parte I
Authors: Miranda-Novales María Guadalupe , Villasís-Keever Miguel Ángel
Published: January 2021

Uno de los objetivos fundamentales de la investigación es la publicación de los resultados en revistas científicas. Esto implica dos retos: el primero, la elección del diseño adecuado, y el segundo, la redacción simple, concreta y correcta para que el trabajo pueda aceptarse en la revista más apropiada, de acuerdo con el tema de investigación. A pesar de los numerosos documentos de apoyo disponibles para mejorar ambos aspectos, el proceso de publicación es largo y puede desanimar al investigador más entusiasta. Éste es el primero de varios artículos que tienen como objetivo describir los pasos, desde la pregunta de investigación hasta la publicación del estudio. En primer lugar abordaremos la importancia del diseño de investigación. La estructura del protocolo de investigación es esencial para alcanzar los objetivos; el protocolo es de utilidad para organizar la investigación de manera lógica, comprensible y de manera eficiente.
Diversidad fenotípica y funcional de los linfocitos B
Authors: Santos-Argumedo Leopoldo
Published: January 2021

Durante muchos años se ha considerado que la función de los linfocitos B es únicamente servir de precursores de las células plasmáticas productoras de anticuerpos; sin embargo, esta visión reduccionista se ha cuestionado en los últimos 30 años. La primera gran sorpresa ocurrió en el decenio de 1970, cuando se demostró que los linfocitos B no constituyen una población homogénea, sino que está constituida por diversas subpoblaciones con origen y funciones distintas que incluyen a la inmunidad innata y la adquirida. Durante el decenio de 1980 se descubrió que los linfocitos B son una fuente importante de citocinas y que extienden sus funciones de la presentación de antígenos a los linfocitos T a funciones de cooperación celular. A partir del año 2000 quedó claro que las células B son tan heterogéneas, hablando en términos funcionales, como lo son los linfocitos T, y que extienden sus funciones a la regulación de la respuesta inmunológica. La historia aún no concluye porque sigue el descubrimiento de nuevas funciones, que tendrán que ser incorporadas al corpus principal del conocimiento acerca de los mecanismos mediante los cuales funciona la respuesta inmunológica. Así, podemos concluir con una felicitación para los linfocitos B por estos primeros 50 años, y les auguramos al menos otros 50 años más de crecimiento robusto.
Redes sociales para la vigilancia de niños con asma tratados en un programa especializado: expectativas de los padres y los cuidadores
Authors: Urrutia-Pereira Marilyn , Ávila Jennifer BG , Chérrez-Ojeda Iván , Ivancevich Juan Carlos , Solé Dirceu
Published: January 2021

Antecedentes: las redes sociales se utilizan para el apoyo de los pacientes con asma; sin embargo, no se conocen las expectativas de los padres y los cuidadores de los pacientes con respecto al uso de estas redes. Objetivo: evaluar las expectativas de los padres y los cuidadores de niños asmáticos atendidos en el Programa de Prevención del Asma Infantil (PIPA, Uruguaiana, RS) con respecto al uso de las redes sociales. Material y método: estudio observacional, descriptivo, de corte transversal, en el que padres y cuidadores de niños tratados en el Programa de Prevención del Asma Infantil respondieron a un cuestionario escrito acerca del uso de las nuevas tecnologías y las diversas aplicaciones para mejorar la información acerca del asma. Resultados: participaron 210 padres o cuidadores (mediana de edad: 25 años; intervalo de edad: 18-42 años) de pacientes con edad promedio de 7.3 años (intervalo de edad: 2 a 18 años) y duración del asma de 4.7 años; 65% de los padres o cuidadores tuvo menos de ocho años de grado de escolaridad. La mayoría de ellos (72%) no tenía acceso a Internet a través de sus teléfonos y sólo 18% obtenía información activamente acerca del asma por Internet; 87% refirió su interés por recibir información a través de las redes sociales. Conclusión: los padres o cuidadores de niños atendidos en el Programa de Prevención del Asma Infantil expresaron gran interés en el uso de redes sociales, pero pocos las usan para controlar la enfermedad de los niños. Aunque las redes sociales proporcionan un gran beneficio para la salud, esta información debe ser vigilarse en relación con su fiabilidad y calidad. La privacidad de los usuarios (médicos y pacientes) debe ser preservada y debe facilitarse su acceso a Internet.
Repercusión de la contaminación del aire en la aparición de asma
Authors: Sánchez Jorge , Caraballo Luis
Published: January 2021

La contaminación del aire influye en el origen y la evolución de las enfermedades respiratorias. El incremento en la frecuencia que ha tenido el asma en los últimos años se asocia con el aumento de los contaminantes atmosféricos y es secundario a la liberación de gases y pequeñas partículas producidas a partir de la combustión de derivados del petróleo, humo de cigarrillo, etcétera. Se conocen algunos mecanismos acerca de cómo estos contaminantes pueden influir en el asma y otras enfermedades alérgicas: 1) al actuar como irritantes en las células alveolares o epiteliales, 2) por su acción coadyuvante en los alergenos en el proceso inflamatorio y 3) por mecanismos epigenéticos. En esta revisión trataremos los mecanismos fisiopatológicos por los que los contaminantes del aire se convierten en factores de riesgo de asma y otras enfermedades alérgicas.
Dependency Parsing for Arabic Quran using Easy-First Parsing Algorithm
Authors:   Department of Informatics, Universitas Telkom, Hafsa Alfiya , Bijaksana Mochammad ,   Department of Informatics, Universitas Telkom, Huda Arief ,   Department of Mathematics, Universitas Islam Negeri Sunan Gunung Djati Bandung
Published: January 2021

Arabic is the main language of Al-Quran. Nowadays, many people are studying the Language of Al-Quran, called Quran Arabic. For the beginners, it is important for them to understand the syntactic relationship in a sentence found in the Qur'an. If they do not understand enough, the interpretation will be different and wrong. It will turn into dangerous because Al-Quran is a source of guidance for Muslims’ life. Dependency parsing is very important for linguistic research, especially for rich languages such as the Arabic Language. This study aims to build dependency parsing, in order to make it easier to get to understand syntactic relationship information in sentences. This study uses a parsing method called deterministic parsing, which the method used is shift-reduce parsing with the Easy-First parsing algorithm. The evaluation used labeled attachment score calculation. The score generated from the evaluation was 69.7, beforehand, the comparison both the system results and the gold standard have been done. 62 sentences found the correct head and relation in each word. The number of words found to be wrong is not more than 3 words in one sentence. Evaluation scores produced are not exorbitant due to the complicated tagset used and lacking test sentences.
A Need Analysis of Blended Learning Model for Deaf Students in Higher Education
Authors:   Department of Special Need Education, Universitas Negeri Padang, Utami Iga , Budi Setia ,   Department of Special Need Education, Universitas Negeri Padang, Nurhastuti Nurhastuti ,   Department of Special Need Education, Universitas Negeri Padang
Published: January 2021

Student diversity is one of the demographic advantages of education. One type of diversity is the registration in higher education students with special needs. For this purpose, teachers as educators are expected to be able to provide all students with adaptive teaching. Although the number of students with special needs is still a minority, educators still need to provide full education for them. Appropriate teaching can be achieved with the use of information technology, in particular the Internet. The use of the Internet as a support for classroom activities can be realized in a blended learning model. However, for each model to be used, an analysis study needs to be performed in order to have optimum results. The purpose of this study is to recognize needs and to obtain information on a blended learning model for deaf students in higher education. Needs analysis is carried out by means of a survey approach using a questionnaire provided to deaf students. The data were analyzed descriptively. The results have shown that deaf students meet the criteria for the development of a mixed learning model. Based on the study, it was concluded that the blended learning model can be applied to deaf students.
Pengembangan Aplikasi Lelang Karet Berbasis Mobile Sebagai Pendukung Akses Informasi Lelang
Authors:   Program Studi Sistem Informasi, Universitas Bina Darma, Andri Andri , Suyanto Suyanto ,   Program Studi Sistem Informasi, Universitas Bina Darma
Published: January 2021

Rubber auction cooperatives are cooperatives whose main function is to auction rubber agricultural products for these member communities. Currently, among the problems that exist in the auction process, namely: first, auction entrants must come to the auction site even if only to bid a price. Second, the auction administration process has redundant of entrant data due to having to fill out a form every time they participate in the auction. From these two problems, this research will conduct application development as an auction medium for related parties. The application developed is a mobile-based application so that it can be accessed easily by all parties. The method used in the development process is the adaptive software-development method with three major stages of speculation, collaboration, and learning which was tested using black box testing. The Research Results are an application with the main feature of conducting the auction process from the cooperative's side, and auction participants can bid prices through the application. The application developed also functions properly in accordance with existing features as evidenced by the results of application testing using the black box technique so that it can help the rubber auction process for related parties.
Pengukuran E-learning Readiness Pada Mahasiswa Sebagai Upaya Penerapan Pembelajaran Jarak Jauh Masa Pandemi COVID-19
Authors:   Program Studi Informatika, Universitas Indraprasta PGRI, Sulistyohati Aprilia
Published: January 2021

One of the efforts to reduce COVID-19 cases is a Distance Learning (PJJ) system for all levels of education. This study aims to determine the e-learning readiness of Cikarang University. Measurement of e-learning readiness implementation is carried out using the ELR framework. In this study, the ELR framework has consist of 4 main components, that are technology, innovation, people and self-development. This research was conducted on student in Cikarang University. Collecting data used structured interview with the campus management and then distributing questionnaires. The data processing used descriptive statistical techniques then mapped the e-learning Readiness index. The results of this study is to show that the Faculty of Engineering Cikarang University in the third level (ready) in implementing e-learning, but still requires improvement and preparation in several aspects to achieve success in implementing e-learning. Some recommendations are proposed for Cikarang University, that is the availability of an e-learning system that can fulfill students' need for learning and assigning. In addition, the campus is expected to be able to conduct socialization and training on e-learning to students so that it makes students understand the e-learning system at Cikarang University.
Prototype Sistem Monitoring Infus Berbasis IoT (Internet of Things)
Authors:   Program Studi Teknik Komputer, Universitas Hamzanwadi, Akbar Taufik , Gunawan Indra ,   Program Studi Teknik Komputer, Universitas Hamzanwadi
Published: January 2021

The development of increasingly sophisticated medical science and technology has an impact on the development of science and technology in the field of medical-devices. One of the existing equipment and is often used in hospitals, one of which is an IV. Currently in the world of health, infusion is still controlled manually. Because it takes time if the nurse has to go back and forth throughout the patient room. Not only is it time consuming, but there will be risks if it is too late to treat a patient whose infusion has run out. Technology needs to be used to minimize risks in the medical world, one of which is the application of IoT technology. This study aims to make it easier for nurses to control infusion conditions in real time using the concept of IoT ( the Internet of Things). The method used is the Waterfall method. This research uses hardware consisting of Load Cell with the HX711 module as a weight sensor, NodeMCU V3 as a processor, and Thingspeak Web server as the interface with the user. The results of the measurement of the tool made have an error of 0.25 Gram, sending data to the Thingspeak.com Server requires a good connection for maximum results.
Dynamic Characteristics Evaluation on Portable Steel Frame due to Mass Irregularities
Authors:   Jamilus Research Centre, Universiti Tun Hussein Onn Malaysia, 86400 Parit Raja, Batu Pahat, Johor, MALAYSIA, Kamarudin Ahmad Fahmy , Ibrahim Azmi ,   Faculty of Civil Engineering, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, MALAYSIA, Mokhatar Shahrul Niza ,   Jamilus Research Centre, Universiti Tun Hussein Onn Malaysia, 86400 Parit Raja, Batu Pahat, Johor, MALAYSIA, Zainal Abidin Mohd Hazreek ,   Jamilus Research Centre, Universiti Tun Hussein Onn Malaysia, 86400 Parit Raja, Batu Pahat, Johor, MALAYSIA, Faisal Ade ,   Program Studi Teknik Sipil, Universitas Muhammadiyah Sumatera Utara, Jl. Muctar Basri, 20238 Medan, INDONESIA
Published: January 2021

Application of irregular mass configuration in modern design era of buildings is unavoidable in order to serve various building functionality. The effect of mass irregularities was investigated on 5-storey portable moment resisting steel tower (PostFrame), against its dynamic behaviour. PostFrame was designed at five meter height and assembled on the strong floor in Jamilus Research Centre laboratory, UTHM. The predominant frequencies and mode shapes were determined on bare frame, uniform mass frame and mass irregularities’ frames. A total of four steel blocks at 800 kg were placed in uniform, ascending and alternating orientations on the first to fourth level of the PostFrame. Ambient vibration testing (AVT) was conducted using uni-axial accelerometer sensors. The sensors were aligned in bi-axial horizontal directions with respect to the North-South (NS) and East-West (EW) directions. ARTeMIS processing tool and Frequency Domain Decomposition (FDD) methods were used in the analysis of dynamic behaviour. Comparative findings were made between bare frame and mass action frame. Two translation mode shapes and torsional mode were illustrated by respective three predominant frequencies. Significant reduction of predominant frequency showed up to 37.79% between bare frame and frame with ascending mass orientation.Uniform mass orientation shows at the lowest percentage discrepancy percentage compared to others. Even though some changes have be found in predominant frequencies, but comparable mode shapes illustration were observed from all three predominant frequencies from all frame configurations.
The third front of the Russian Civil War. Bagging
Authors: Podolsky Sergey
Published: January 2021

THE THIRD FRONT OF THE RUSSIAN CIVIL WAR. BAGGING
Memory of the Great Patriotic War in memorials and monuments of the Stavropol Territory
Authors: Kolesnikov Ilya , Menyaylov Aleksandr , Kasparyan Konstantin
Published: January 2021

The article examines the monuments and memorials of Stavropol, dedicated to the Great Patriotic War, their importance in the formation of patriotism among the younger generation. During the research, the following special-historical methods were used: biographical, historical-genetic, idiographic. On the basis of the collected material, a map of monuments and memorials of the resort cities of the Stavropol Territory was created: Zheleznovodsk, Lermontov, Mineralnye Vody.
Management specifics of cultural, leisure, educational, and communication activities in special settlements of the North in 1930s-1940s
Authors: Lobchenko Liudmila
Published: January 2021

The article deals with the specifics of cultural, mass communication and educational activities aimed at special settlers in the North in 1930s-1940s. The article shows various ways and forms of work by Soviet party authorities and public organisations aimed at ideological and moral “training” of the special settlers.
Ethno-confessional factor in the activities of the Crimean Regional Government M.A. Sulkevich (June-November 1918)
Authors: Kalinovsky Vladimir , Puchenkov Alexander
Published: January 2021

The article describes the specificity of the ethno-confessional policy of the Crimean regional government of M.A. Sulkevich (June - November 1918). The circumstances of the general’s coming to power in the Crimea and the events preceding this, in which the national question played an important role, are noted. The significance of the ethno-confessional factor in the work of the cabinet of M.A. Sulkevich, the contradictory nature of his activities was proved. The relationship between M. A. Sulkevich with the Ukrainian State of Hetman P.P. Skoropadsky, who also had a national motive.
Countering the abuse of their duties under customary law among the don Cossacks in the second half of the 19th century
Authors: Krasnov Sergey
Published: January 2021

In this publication the author first conducts a specific historical reconstruction of the different methods and (or) measures the customary law of responsibility, which has always used the Don Cossack community as a reciprocal means and (or) the punishment of offenders, and the use of which allowed members of the Don Cossack communities to delineate the customary law of responsibility for the violation of simple prohibitions, which were established by certain norms of customary law.
“Hello, dear ones!”: from the letters of captain F. S. Leontiev to the family
Authors: Khubulova Svetlana
Published: January 2021

A selection of letters of captain F. S. Leontiev was first introduced into scientific circulation. The epistolary legacy of many combatants has not yet become the subject of independent analysis, although the letters from the front contain a lot of factual material about military everyday life, the mood in the army environment, and front-line everyday life. Frontline letters with a certain subjectivity in the coverage of events can become the basis for deep and detailed research on military anthropology.
Üçüncü Derece Arkeolojik Sit Alanlarını Koruma: Lampsakos Nekropol Alanı
Authors: AKSOY Erman
Published: January 2021

Bu çalışmada Çanakkale-Lapseki Dalyan Mevkiinde yer alan Antik Lampsakos Kenti Kuzey Nekropolü sürdürülebilir koruma bağlamıyla değerlendirilmektedir. Çanakkale Boğazına sınırdaş konumuyla kuruluşundan bugüne sürekli yerleşim alanı olan Lapseki kenti, uluslararası ulaşım ağına 1915 Çanakkale Köprüsü ile yeniden bağlanacaktır. Bu sürecin kentle birlikte miras alanlarını da etkilemesi, kent çeperindeki arkeolojik sit alanlarında koruma planlamasına ivme kazandırmıştır. Bu çalışmanın konusu olan koruma amaçlı imar planı da bu süreçte hazırlanmaktadır. Arkeolojik sit alanındaki eserlerin müzelere taşındığı ve günümüzde alanda herhangi bir arkeolojik kalıtın bulunmadığı bilinmektedir. Bu nedenle üçüncü derece arkeolojik sit alanı tescil statüsündeki nekropol alanı, koruma mevzuatı hükümlerine göre; koruma planıyla inşaat öncesi sondaj kazısı yapılması koşuluyla yapılaşmaya açılmıştır. Bu durumda, farklı uzmanlardan oluşan planlama ekibi, arkeolojik mirasın sürdürülebilirliğini önemseyerek, yapılaşmaya açılabilen bu arkeolojik sit alanının sembolik değerlerle kent kimliğine ve kentin belleğine kazandırılmasını önermiştir. Böylece, mevzuata göre yapılaşmaya açılacak arkeolojik sit alanlarının ya da müzelerde sergilenen eserlerinin, kentin simgesi olarak sürdürülebilirliği öngörülmüştür.
Küresel Kentlerin Anlamsal İnşası: Web Sayfaları Üzerinden Toplumsal Göstergebilimsel Bir Analiz
Authors: ÇOBANGİL Orçun
Published: January 2021

Küreselleşme süreci ile hâkim hale gelen Neoliberal ideoloji içerisindeki postfordist üretim rejimiyle birlikte yaşanan dönüşümler, kentleri küresel ile ilişkili olarak doğrudan önemli bir aktör konumuna getirirken, diyalektik bir ilişki içerisinde hem kentlerden güç almakta hem de kentleri dönüştürmektedir. Bu bağlamda bu çalışma, bu ilişki çerçevesinde dönüşen/dönüştürülen kentlere ilişkin harekete geçirilen toplumsal göstergeleri ve sembolik anlam inşalarını inceleme amacını taşımaktadır. Bunun için, öncelikle küresel kentin anlamı ve işlevleri üzerine bir giriş yapıldıktan sonra, küresel kentlere ilişkin göstergeleri incelemek için kullanılabilecek toplumsal göstergebilim yaklaşımı tarihsel ve kuramsal çerçeve içinde ele alınacak ve literatürden örnek çalışmalar ile işlevsellikleri değerlendirilecektir. Bu çalışmalarla ilişkili olarak, postmodern kent tahayyülleri ve kentlerin markalaşma süreçlerine değinilerek, göstergelerin ideolojik arka planı incelenecektir. Daha sonra, seçilmiş küresel kent örnekleri üzerinden kentlerin resmi web sayfalarında kullanılan kentlerin küresel gücüne ilişkin yazılı temsiller toplumsal göstergebilimsel bir bağlamda ele alınarak, seçilen göstergelerin küresel kentin anlamsal inşasında nasıl rol oynadıkları, eleştirel bir epistemoloji içerisinde değerlendirilecektir.
Temalı Konut Projelerinde Kullanılan Reklam Dilinin Kent Yaşamındaki Postmodern Göstergeleri
Authors: KARABAĞ Çiğdem , HASGÜL Esin
Published: January 2021

Kent ve kent nosyonu, postmodern tüketim kültürünün etkisi ile oluşan toplumsal örüntüler çerçevesinde, bu üslubu yansıtan temalı mekânlara dönüş(türül)mektedir. Postmodernizm karakterini sergileme çabası içinde kurgulanan mimari yapılanmalar, gösterge ve imajlarla bireye gerçekdışı bir yaşamın anahtarını sunmaktadır. Alman felsefeci Walter Benjamin, kapitalizmin reklam gibi dinamikleri kullanarak her türlü imgeyi kendi içine alma ve dönüştürebilme durumunu “imgeleri çalmak” olarak tanımlamaktadır. Postmodern kentteki yaşam anlayışı artık “hipergerçeklik” kavramı üzerinden temalı konut projeleri adı altında işleyen bir model kurgulamaktadır. Yapay ortamlarda kurulu kopyala-yapıştır inşası ile gerçekleşen yeni kent parçaları; Baudrillard’ın rasyonel gerçekliğin yerini sentetik gerçekliğin alması olarak adlandırdığı ”simülakr” kavramıyla ilişkilenmektedir. Bu doğrultuda çalışma kapsamında; 2000-2020 yılları arasında yazılı ve görsel medyada yayınlanan, reklam tanıtımlarında tema içeriği olan ve İstanbul kenti özelindeki çoklu konut üretimleri incelenmektedir. Projeler konut proje görselleri, reklam metinleri ve tanıtım filmleri üzerinden seçimler yapılarak söylem analizi yöntemiyle değerlendirilmektedir. Böylelikle, postmodern tüketim kültürünün mimari üslubu eklektik bir anlayış ile çevreleyen reklam dilinin yansımaları ve yeni yaşam kültürünün göstergeleri ortaya koyulmuştur.
Dini Yapılar Ve Kent Kimliği İlişkisi Üzerine Bir Değerlendirme: Trabzon Örneği
Authors: YILMAZ YILDIRIM Demet , YETİM Şeyma
Published: January 2021

Her yapı kentsel bütün içinde yerini alarak kent kimliğine pozitif veya negatif olarak katkıda bulunmaktadır. Dini yapılar da biçimlenme ve konumlanma açısından kent dokusunda ve/veya kent siluetinde farklılıkları, tekillikleri veya egemenlikleriyle öne çıkan ve kullanıcı belleğinde kalıcı izler bırakan yapılardır. Hatta günümüzde dini yapıların biçimlenmesinin ötesinde konumlandırıldığı yerin yapıya özgünlük katmakta daha da etkili olduğu görülmektedir. Ayrıca bu yapılarda yapılanın ve yaptıranın gücünü görmek mümkündür. Tüm bunlar dini yapıların imaj üzerinden kent kimliğindeki yerini ve önemini ortaya koymaktadır. Çalışmada Trabzon’da dini yapıların kentle ilişkisini işaret öğesi olma potansiyelleri üzerinden ortaya koymak ve dini yapıların kent bütünündeki yerini tartışmak amacıyla fiziksel ve işlevsel analizler yapılmıştır. Bu analizlerde Coğrafi Bilgi Sistemi (GIS) üzerinden ArcMap 10.3 ve ArcScene 10.3 kullanılmıştır. Trabzon kent merkezi sınırları içinde yapılan çalışma kapsamında analizlerde öne çıkan dini yapılar tespit edilerek, bu yapıların çevrelerinde yapılacak düzenlemelere veya yeni yapılacak dini yapıların konumlarının belirlenmesine yönelik veriler ortaya konmuştur
Theoretical Problems of Legal Regulation of Innovations in the Medical Field: Experience in Counteracting Covid-19
Authors: Fedorov Valentyn , Kravchenko Sergii , Reznichenko Hanna , Opara Nataliia , Tsybokhin Oleg
Published: January 2021

The work is devoted to identifying the main problems of legal regulation of innovations in the medical field and developing the best options for solving them in the context of the Covid-19 pandemic. Thus, the research methodology is based on general and special scientific methods, in particular: formal legal, historical and legal, comparative analysis, and modeling. So, the procedure and issues to be considered are as follows. In the introduction, we will briefly highlight the origins of intellectual property rights issues in the medical field and the overall state of the pharmaceutical industry. In the first subsection of the third section, we will consider the positions of the main players in the pharmaceutical industry and the contradictions between them. In the second subsection, we will highlight the international obligations under TRIPS. In the third subsection, we will consider the consequences of their direct violation. In the fourth subsection, the impact of Covid-19 and the methods of legal regulation of medical innovations and patents under the TRIPS agreement will be discussed. In the fifth subsection, we will propose a way out and a compromise according to the Indian scenario. As a result of the study, contradictions were identified in the aspect of maintaining the balance of private and public interests between states and international pharmaceutical companies in the context of a pandemic and proposed ways to resolve them within the existing legal methods under the TRIPS agreement to achieve an acceptable compromise.
Ensuring a Balance Between Public and Private Interests in the Implementation of Quarantine Measures
Authors: Lazur Yaroslav , Karabin Tetyana , Martyniuk Oleksander , Bukhanevych Oleksandr , Kanienberh-Sandul Oksana
Published: January 2021

Under the influence of the spread of coronavirus infection, the world community has faced difficult challenges that provoke changes in the seemingly already stabilized legal regulation, putting at risk the settlement of human rights and the common good. The study aims to find effective mechanisms for balancing human rights and public interests in the context of their legal regulation. Specifically, this study is focused on the mechanisms of balancing private and public interests in the implementation of quarantine measures in the Covid-19 pandemic. The research methods were both general scientific and special methods, in particular: formal legal, historical and legal, analysis and synthesis. To perform the tasks of the work, the following structure was used: after some initial precisions, there are provided some considerations about the fiscal stimulus measures and about the exercise of the right of derogation; then, the study deals with the problem of lawmaking in a pandemic; and finally it is considered the threats to intellectual property in the sphere of healthcare. The results of the work show that the pandemic has seriously hit the balance between private and public interests. The public interests of the government and society have become a priority, but in many cases, the measures that infringe private interests are disproportionate, untimely and inefficient.
Bloggers, Copyrights and Some Other Legal Issues
Authors: Kyryliuk Alla , Lysenko Viktoriia , Podolieva Alina
Published: January 2021

The purpose of the study is to find out the place of the blog in the field of copyright; identification the most pressing problems that may arise as a result of blogging; and finding the most effective approaches and options to solve the above problems. The object of research is the system of national and foreign legislation, legal doctrine, bills in the field of intellectual property, and copyright. Empirical methods such as observation and description and theoretical methods such as analysis, synthesis, generalization, and explanation were used in this work. The work has the following structure: first, it takes care of the differences in understanding of copyright regulation in different legal systems, the world experience in regulating intellectual property, and its history. Then, blog copyrights are analyzed, as well as online copyright infringement, ways to protect content, and some other actual realities.  As a result of the study of the intellectual property legislation that governs this subject—in particular, in the field of copyright and related rights—there is a clarification of the notion of “blog” and the regulation that governs blogging in Ukraine is identified. In addition, some practical recommendations were given to bloggers on legal protection of their copyrights.
Effects of Geometric Sound on Brainwave Activity Patterns, Autonomic Nervous System Markers, Emotional Response and Faraday Wave Pattern Morphology
Authors: Geffen Rona , Braun Christoph
Published: January 2021

This study introduces Geometric Sound as a subfield of spatial sound featuring audio stimuli which aresonic holograms of mathematically defined 3D shapes. The effects of Geometric Sound on human physiology were investigated through EEG, heart rate, blood pressure and a combination of questionnaires monitoring 50 healthy participants in two separate experiments. The impact of Geometric Sound on Faraday wave pattern morphology was further studied. The shapes examined, Pyramid, Cube, and Sphere, exhibited varying significant effects on autonomic nervous system markers, brainwave power amplitude, topology, and connectivity patterns, in comparison to both the control (traditional stereo), and recorded baseline ofparticipants where no sound was presented. Brain activity in the Alpha band exhibited the most significantresults, additional noteworthy results were observed across analysis paradigms in all frequency bands.Geometric Sound was found to significantly reduce heart rate and blood pressure and enhance relaxationand general well-being. Changes in EEG, heart rate, and blood pressure were primarily shape-dependent,and to a lesser extent sex-dependent. Pyramid GS yielded the most significant results in most analysisparadigms. Faraday Waves patterns morphology analysis indicated that identical frequencies result inpatterns that correlate with the excitation Geometric Sound shape. We suggest that Geometric Sound showspromise as a non-invasive therapeutic approach for physical and psychological conditions, stress-relateddisorders, depression, anxiety, and neurotrauma. Further research is warranted to elucidate underlyingmechanisms and expand its applications.
PENGATURAN KADER KESEHATAN MELALUI EDUKASI GIZI DALAM MENGATASI ANEMIA PADA IBU HAMIL
Authors: Sohara
Published: January 2021

Anemia merupakan masalah kesehatan masyarakat terbesar di dunia terutama bagi kelompok usia reproduksi/Wanita Usia Subur (WUS). Anemia pada WUS dapat menimbulkan kelelahan, badan lemah, penurunan kapasitas/kemampuan atau produktivitas kerja. Bagi ibu hamil, anemia berperan pada peningkatan prevalensi kematian dan kesakitan ibu, dan bagi bayi yang dapat meningkatkan resiko kesakitan dan kematian bayi, serta Bayi Baru Lahir Rendah (BBLR). Tingginya prevalensi anemia pada ibu hamil merupakan masalah yang tengah di hadapi pemerintah Indonesia (Kemenkes RI, 2014). Angka kematian ibu (AKI) atau maternal mortality rate (MMR) mencerminkan risiko yang di hadapi ibu-ibu selama kehamilan dan melahirkan yang dipengaruhi oleh status gizi ibu, keadaan social ekonomi, keadaan kesehatan yang kurang baik menjelang kehamilan,kejadian berbagai komplikasi pada kehamilan dan kelahiran, tersedianya dan penggunaan fasilitas pelayanan kesehatan termasuk pelayanan prenatal dan obstetri (Amalia, 2017)
C17orf37 is a differentially expressed gene in brain metastatic human breast cancer.
Authors: Mamoor Shahan
Published: January 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that open reading frame 37 on chromosome 17, also known as the migration and invasion enhancer 1 (MIEN1), encoded by C17orf37, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. C17orf37 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Modulation of C17orf37 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Alih Aksara dan Alih Bahasa Teks Tafsir Ayat Ya Ayyuhannas
Authors: Dayanti Rosi , Nurizzati  , Adek Muhammad
Published: January 2021

The purpose of this research is to: (a) describe the physical form of Tafsir Ayat Ya Ayyuhannas manuscript by Haji Abdul Latif Syakur; (b) display the transliteration result of Tafsir Ayat Ya Ayyuhannas text by Haji Abdul Latif Syakur; and (c) present the translation result of Tafsir Ayat Ya Ayyuhannas text by Haji Abdul Latif Syakur. This research was classified as philology research. The result of this research is: (1) the description of Tafsir Ayat Ya Ayyuhannas manuscript by Haji Abdul Latif Syakur; (2) the transliteration of Tafsir Ayat Ya Ayyuhannas text by Haji Abdul Latif Syakur from Arabic-Malay script to Latin script; (3) the translation of Tafsir Ayat Ya Ayyuhannas text by Haji Abdul Latif Syakur was translated from old Malay to Indonesian.
BAHAN AJAR ADMINISTRASI PENDIDIKAN
Authors: Arsyam Muhammad
Published: January 2021

Selain itu, pengertian administrasi secara sempit dapat diartikan sebagai bentuk aktivitas yang meliputi catat-mencatat, surat-menyurat, pembukuan sederhana, ketik-mengetik, dan kegiatan lain yang sifatnya teknis ketatausahaan. Sedangkan pengertian administrasi secara luas adalah semua proses kerjasama antara dua orang atau lebih yang bertujuan untuk mencapai target dengan memanfaatkan sarana dan prasarana tertentu secara berdaya guna dan berhasil guna
Unusual public pressure on retraction decision during crisis
Authors: Le Tam Tri
Published: January 2021

During the COVID-19 pandemic, the mainstream media and social media may have imposed more pressure on retraction decision of COVID-19 related academic papers.
SYP is a differentially expressed gene in brain metastatic human breast cancer.
Authors: Mamoor Shahan
Published: January 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that synaptophysin, encoded by SYP, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. SYP mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of SYP in primary tumors was significantly correlated with patient recurrence-free survival. Modulation of SYP expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Function and regulation of interleukin-10 in breast cancer
Authors: The Annals of Research  , Al-Ameri Samed Ahmed Al-Ezzi
Published: January 2021

Breast Cancer (BC) is the most common cancer in women and the second cause of death in females due to cancers. Most genetic studies point to a significant relationship between Interleukin 10 (IL-10) and BC. IL-10 is strongly expressed in tissues of BC and negatively correlated with the prognosis of several tumors, including breast cancer. In breast cancer cells, the down-regulation of miRNA-141 inhibits IL-10 and contributes to an up-regulation of COX-2, PGE-2, and TNF-α expression. Long non-coding RNR SNHG1 has been increased in CD4 + TIL cells in patients with breast cancer, whereas siRNA-SNHG1 can decrease the expression of Foxp3 and IL-10. Overexpression of IL-10 failed to manage immunogenic cancer. And the inhibition of IL-10Rα improved the therapeutic benefit of chemotherapy in the breast cancer model. The mechanisms of IL-10 in breast cancer are controversial. Interleukin-10 is documented to demonstrate both anti-and pro-tumor acts. IL-10 is strongly expressed in tissues of BC, which has a negative correlation with breast cancer prognosis and tumor marker. Besides, IL10 levels in serum are elevated for patients with BC than normal controls people, which also correlates with poorer outcomes. IL-10 stimulated cancer cell replication and metastasis. IL10 is currently under study as a potential therapeutic targeting inflammatory disease as well as cancer. In conclusion, IL-10 seems to be the future diagnostic biomarker and therapy target of breast cancer. Though lncRNA seems to be a significant research spot, very little research in lncRNA and IL-10 is found. Consequently, in future IL-10 research topics, new studies related to lncRNA could occur.
Towards a more integral environmental-friendly culture
Authors: Le Tam Tri
Published: January 2021

The environmental-friendly culture model on enterprises can be expanded to cover more aspects.
Review of “Mapping the intellectual and conceptual structure of research on gender issues in the family business: A bibliometric review”
Authors: Le Tam Tri
Published: January 2021

A brief review of “Mapping the intellectual and conceptual structure of research on gender issues in the family business: A bibliometric review”
Review of “Healthcare consumers’ sensitivity to costs a reflection on behavioural economics from an emerging market”
Authors: Le Tam Tri
Published: January 2021

Findings on healthcare consumers’ sensitivity to costs In Vietnam can become a good lesson in time of public health crisis.
AP1G2 is a differentially expressed gene in human metastatic breast cancer, in the brain and in the lymph nodes.
Authors: Mamoor Shahan
Published: January 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that AP-1 complex subunit gamma-like 2, encoded by AP1G2, was among the genes whose expression was most different in the brain and lymph node metastases of patients with metastatic breast cancer. AP1G2 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of AP1G2 in primary tumors was significantly correlated with patient recurrence-free survival in patients with breast cancer. Modulation of AP1G2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain while evading immune clearance in the lymph nodes in humans with metastatic breast cancer.
NARFL is a differentially expressed gene in human metastatic breast cancer, in the brain and in the lymph nodes.
Authors: Mamoor Shahan
Published: January 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that nuclear prelamin A recognition factor-like, encoded by NARFL, also known as CIAO3, was among the genes whose expression was most different in the brain and lymph node metastases of patients with metastatic breast cancer. NARFL mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of NARFL in primary tumors was significantly correlated with patient recurrence-free survival in patients with breast cancer. Modulation of NARFL expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain while evading immune clearance in the lymph nodes in humans with metastatic breast cancer.
About suggestion of publicly open limitations section for academic papers
Authors: Le Tam-Tri
Published: January 2021

It may be feasible to implement mandatory publicly open limitations section in academic papers.
JAUHI NARKOBA LINDUNGI ASET NEGARA
Authors: Yulia
Published: January 2021

Penyalahgunaan narkoba adalah suatu perilaku ketika seseorang menggunakan oobat-obatan golongan narkotika, Banyak sekali dampak yang terjadi saat penyalahgunaan narkoba seperti sulit tidur, kehilangan keseimbangan tubuh, halusinasi, dehedrasi, penyakit jantung bahkan kematian. Penyalahgunaan narkoba terdiri dari berbagai Kalanga dari remaja sampai orang dewasa. Remaja merupakan aset berharga sebuah nagara yang harus dijaga agar terhindar dari penyalahgunaan narkoba, adapaun beberapa cara untuk mencegahnya yaitu dari segi agama, orang tua, lingkungan, temen sepergaulan dan juga diri sendri.
Imagination, anxiety, and loneliness during the COVID-19 pandemic.
Authors: Zabelina Darya , Clay John , Upshaw Joshua
Published: January 2021

Imagination is relevant in many aspects of our lives, and has been associated with creativity and overall cognitive development, yet imagination may also have a dark side. In two studies we examined the link between imagination, anxiety, and loneliness during the COVID-19 pandemic. US college students (N = 101, Study 1) and participants from an international community sample (N = 61, Study 2) were tested around the time that rates of COVID-19 cases were escalating. Across both samples, we found that spending more time in one’s imagination was associated with elevated levels of anxiety. Furthermore, frequency of imagination interacted with loneliness in predicting changes in anxiety during, compared to before the pandemic. Specifically, lonely people who spent more time imagining experienced the largest increases in anxiety during, compared to before the pandemic. In Study 1 valence of imagination and changes in anxiety were also moderated by feelings of loneliness, although this effect was not replicated in Study 2. Results indicate that at least some features of imagination, particularly how much time people spend in imaginative states, may be associated with negative mood states, such as feelings of anxiety. Implications and future directions are discussed.