bluuebunny/crossref_metadata_2025 huggingface dataset:
AS CONSEQUÊNCIAS JURÍDICAS E PSICOLÓGICAS DIANTE DO ABORTO INDUZIDO NO BRASIL
Authors: Medeiros Silva Liviah Anne , Tayrone Cachina Silva Matheus
Published: October 2021

Localizando-se na interdisciplinaridade entre direito e psicologia. É certo que o aborto já existe em sociedade, em razão das exceções que o Código Penal estipula, nesse sentido, o presente estudo questiona o motivo de ainda a lei penal brasileira punir a mulher que objetiva interromper a gestação, isto é, induzir o aborto. Dessa forma, objetivou-se analisar o aborto no Brasil, enfatizando as principais consequências referentes a essa temática sob um olhar jurídico e psicológico, utilizando-se a revisão bibliográfica como método.
The Impact of Traditional Chinese Medicine on Mitophagy in Disease Models
Authors: Yu Li-Ping , Shi Ting-Ting , Li Yan-Qin , Mu Jian-Kang , Yang Ya-Qin , Li Wei-Xi , Yu Jie , Yang Xing-Xin
Published: October 2021

:

Mitophagy plays an important role in maintaining mitochondrial quality and cell homeostasis
through the degradation of damaged, aged, and dysfunctional mitochondria and misfolded proteins. Many human
diseases, particularly neurodegenerative diseases, are related to disorders of mitochondrial phagocytosis.
Exploring the regulatory mechanisms of mitophagy is of great significance for revealing the molecular mechanisms
underlying the related diseases. Herein, we summarize the major mechanisms of mitophagy, the relationship
of mitophagy with human diseases, and the role of traditional Chinese medicine (TCM) in mitophagy. These
discussions enhance our knowledge of mitophagy and its potential therapeutic targets using TCM.
Metabolite Identification in the Preclinical and Clinical Phase of Drug Development
Authors: Wu Yali , Pan Lulu , Chen Zhendong , Zheng Yuandong , Diao Xingxing , Zhong Dafang
Published: October 2021

Metabolite identification plays a critical role in the phases during drug development. Drug metabolites
can contribute to efficacy, toxicity, and drug-drug interaction. Thus, the correct identification of metabolites is
essential to understand the behavior of drugs in humans. Drug administration authorities (e.g., FDA, EMA, and
NMPA) emphasize evaluating the safety of human metabolites with exposure higher than 10% of the total drugrelated
components. Many previous reviews have summarized the various methods, tools, and strategies for the
appropriate and comprehensive identification of metabolites. In this review, we focus on summarizing the importance
of identifying metabolites in the preclinical and clinical phases of drug development. Summarized scenarios
include the role of metabolites in pharmacokinetics/pharmacodynamics (PK/PD) analysis, disproportional
exposure of metabolites that contribute to drug toxicity, changes in metabolite exposure in renal-impaired patients,
covalent tyrosine kinase inhibitors (anticancer drugs), and metabolite identification of drug candidates from
natural medicines. This review is aimed to provide meaningful insight into the significant role of metabolite identification
in drug development.
Microencapsulation of Cassia fistula Flower Extract with Chitosan and its Antibacterial Studies
Authors: Suryavanshi Vandana Singh , Maharana Tungabidya , Jagtap Pratik Kumar
Published: October 2021

Introduction:

The plant used in the present study is Cassia fistula, which belongs to the
family Leguminosae and has been used in traditional medicinal systems due to the presence of a copious
amount of Phytochemicals with various properties.

Aims:

This study is focused on the extraction of phytochemicals from the Cassia fistula flower and
its subsequent encapsulation into chitosan matrix for applications in drug delivery. Chitosan is approved
by FDA for its use in Pharmaceutical industries.

Methods:

As described by several analytical techniques such as FT-IR, NMR, Thermal analysis,
and SEM, the microsphere thus prepared by the current study is predicted to release the desired extract
with medicinal properties in a controlled manner, allowing for more convenient and desired
levels of drug administration. The swelling study and release study of the prepared microsphere
have been carried out in physiological pH 2 and 7.4. NMR study has shown that sitosterol and
friedelin have been encapsulated successfully into the chitosan matrix.

Results:

The microspheres have shown up to 80% swelling in pH 2 upto 8 days, and 60% of the in-
-vitro controlled drug release has also been found in pH 2 upto 2 days. The thermal studies using
TGA and DSC supported the thermal stabilities of CS beads, CFFE and CFFE-CS beads, Also, it
showed the dispersion of the CFFE in the cavities of the Chitosan matrix.

Conclusion:

The Biomedical application of the synthesized CFFE-CS beads has also been reported
on the basis of their antibacterial studies.
A New Approach for β-cyclodextrin Conjugated Drug Delivery System in Cancer Therapy
Authors: Kumar Palanirajan Vijayaraj , Sheng Teng Meng
Published: October 2021

Natural cyclodextrins (CDs) are macrocyclic starch molecules discovered a decade ago,
in which α-, β-, and γ-CD were commonly used. They originally acted as pharmaceutical excipients
to enhance the aqueous solubility and alter the physicochemical properties of drugs that fall under
class II and IV categories according to the Biopharmaceutics Classification System (BPS). The
industrial significance of CDs became apparent during the 1970s as scientists started to discover
more of CD’s potential in chemical modifications and the formation of inclusion complexes. CDs
can help in masking and prolonging the half-life of drugs used in cancer. Multiple optimization
techniques were discovered to prepare the derivatives of CDs and increase their complexation and
drug delivery efficiency. In recent years, due to the advancement of nanotechnology in pharmaceutical
sectors, there has been growing interest in CDs. This review mainly focuses on the formulation
of cyclodextrin conjugated nanocarriers using graphenes, carbon nanotubes, nanosponges, hydrogels,
dendrimers, and polymers to achieve drug-release characteristics specific to cells. These
approaches benefit the discovery of novel anti-cancer treatments, solubilization of new drug compounds,
and cell specific drug delivery properties. Due to these unique properties of CDs, they are
essential in achieving and enhancing tumor-specific cancer treatment.
Synthesis and Liquid Crystalline Properties of Low Molecular Weight Bis-
Chalcone Compounds
Authors: Sasidharan Anju K. , Mathew Jomon , Achalkumar Ammathnadu S. , Mathews Manoj
Published: October 2021

Aim:

In this paper, we report on the synthesis and liquid crystalline properties of some low molecular weight bis-chalcone compounds derived from acetone, cyclopentanone and cyclohexanone mesogenic cores.

Background:

Structurally bis-chalcones belong to a broader family of chalcone compounds. Chalcone is a compound that consists of two aromatic rings linked by an unsaturated , -ketone.

Objective:

Liquid crystalline chalcones are prepared by aliphatic chain substituents on two aromatic rings. Chalcones are well studied for their mesomorphic properties. Compared to a large number of chalcone based LCs reported, only a few articles have been published on the mesomorphic properties of bis-chalcone compounds. The target compounds of the present study varied not only in their central core but also in number and position of terminal aliphatic chain substitution-a key structural unit in deciding the liquid crystalline properties of a compound.

Method:

All target compounds were synthesized in good yield by base catalyzed Claisen-Schmidt condensation reaction. Molecular structures were confirmed by FT-IR, 1H NMR, 13C NMR, and mass spectroscopic methods. Liquid crystalline property of these compounds was evaluated using polarizing optical microscopy and differential scanning calorimetry.

Results:

Although none of the acetone based compounds exhibited mesomorphism, cyclopentanone and cyclohexanone based compounds with octyloxy chain at para position on either side of the dibenzylidine ring stabilized liquid crystalline smectic (SmA and SmC) and nematic (N) phases. The observed structure-liquid crystalline property relationship was explained by structural analysis of molecules using DFT calculations. Considering the inherent photoluminescence nature of the chalcone moiety, a preliminary study was carried out on a selected compound to reveal its fluorescence property.

Conclusion:

Our study brings about an important structure-liquid crystalline property relationship in a relatively unexplored class of bis-chalcone liquid crystals.
Novel Benzotriazole Acetamide Derivatives as Benzo-Fused Five-
Membered Nitrogen-Containing Heterocycles - In silico Screening, Molecular
Docking, and Synthesis
Authors: Patil Tejaswini D. , Amrutkar Sunil V.
Published: October 2021

Background:

DNA gyrase subunit B (1KZN) is an attractive target for antibacterial drug development
because of its role in DNA replication. The fast development of antimicrobial medication resistance
necessitates the quick discovery of new antimicrobial medicines.

Objective:

The goal of this research was to design, synthesize, and discover benzo-fused five-membered
nitrogen-containing heterocycles that bind to DNA gyrase subunit B via molecular docking (1KZN).

Methods:

Based on literature research, 2-(1H-1,2,3-Benzotriazol-1-yl)-N-substituted acetamide was synthesized
using an efficient method. All synthesized compounds were evaluated for antibacterial activity
against three distinct organisms: E. coli, Pseudomonas aeruginosa, Staphylococcus aureus. In a docking
investigation, the chemical interacts with the active site of DNA gyrase subunit B (1KZN), indicating that
it might have antibacterial action.

Conclusion:

According to the findings of this research, the compounds 3d and 3f showed antibacterial
properties. For Staphylococcus aureus, 3c has the potential to be an antibacterial agent.
Prevalence and Attitudes Towards Using Protein Supplements Among
Female Gym Users: An Online Survey
Authors: Alhussain Maha H. , Abdulhalim Waad S. , Al-harbi Laila Naif , Binobead Manal Abdulaziz
Published: October 2021

Background:

Protein supplements have become a widespread practice amongst athletes
and gym users worldwide. However, studies on the use of protein supplements among
female gym users in Saudi Arabia are lacking.

Objective:

The aim of this study was to investigate the prevalence of protein supplement usage
among female gym users and their attitudes towards protein supplementation in Riyadh city,
Saudi Arabia.

Methods:

In this cross-sectional study, 502 female gym users aged ≥18 years completed a
structured, self-administered online questionnaire on the usage of protein supplementation. Socio-
demographic information, anthropometry, health status, exercise frequency, attitudes and
knowledge regarding protein supplements were obtained.

Results:

The overall prevalence rate of protein supplement use among the study respondents
was 36.3%. There were significant associations between the use of protein supplements and
educational level (p< 0.05), the duration of being a gym member (p< 0.05) and frequency of
gym visits per week (p< 0.05). Whey protein was the predominantly used supplement (57.8%),
and the reason attributed to the use of protein supplement was muscle building (53.9%). The
main sources of information regarding protein supplement use included the internet (30.2%)
followed by gym coaches (25.3%).

Conclusion:

Our findings demonstrated that a considerable number of females exercising in
gyms use protein supplements, and most rely on unreliable sources for decision-making of protein
supplements use. Nutritional education and consultations regarding protein supplement use
are warranted.
Knowledge of Preeclampsia Among Pregnant Women
Authors: Hamade Rola , Mohsen Amani , Kobeissy Firas , Karouni Ali , Akoum Hikmat
Published: October 2021

Introduction:

Preeclampsia (P.E) has remained a public health threat to both developed
and developing countries. The incidence of preeclampsia in Lebanon is high at 2.84%. Awareness
of P.E among pregnant females is crucial to reduce morbidity and mortality for both fetus and
mother.

Objective:

A cross-sectional observational study was conducted to analyze data from Lebanese’s
pregnant women. This study aims to assess the level of knowledge of PE among pregnant women
in the Lebanese population.

Methods:

This cross-sectional study was conducted between September and December 2020 in obstetricians’
clinics of different health care institutions in five governorates in Lebanon. A closedended
questionnaire was distributed to 400 pregnant females. The first part of the questionnaire
aimed to collect socio-demographic information about the participants. The second part was specified
to assess knowledge on PE. Signs and symptoms, risk factors, and consequences were among
the twenty-three knowledge items assessed. The last part addressed some attitudes about dealing
with this disorder. Responses were scored percentage-wise and grouped into low <60%, moderate
(60-80%), and high (80-100%).

Results:

There is inadequate knowledge of P.E among the Lebanese population. In total, 15.3%
had adequate knowledge of P.E. A linear regression showed that the knowledge score increased in
working pregnant women (p=0.04), who lived in Bekaa (p<0.001), who had a vocational (p=0.01)
or university education (p=0.001) and who had any relative, who developed preeclampsia (p=0.03)
or was suffering from diabetes (p=0.03). Furthermore, knowing when blood pressure is considered
high (p<0.001) and hearing about preeclampsia (p<0.001) also increased the preeclampsia knowledge
score.

Conclusion:

The knowledge of PE among pregnant women in Lebanon is low.
Dietary Polyphenols in the Intervention of Gestational Diabetes
Authors: Mishra Jigeesha , Srivastava Shailendra Kumar , Pandey Kanti Bhooshan
Published: October 2021

Background:

The impact of gestational diabetes mellitus GDM is severe since it is directly associated with the detrimental intra-uterine environment, which may lead to enhanced risk of development of fetal metabolic disorders and affects mother and offspring both. Plant derived polyphenols are reported for their protective roles against a variety of human diseases; however, the impact of adherence to polyphenols on the risk of GDM has not been exhaustively reviewed.

Objective:

Aim of this review is to summarize relevant studies linking polyphenols and polyphenol rich dietary patterns by carefully considering the mechanisms of their action to the risk of GDM and its management.

Method:

Data from PubMed, ScienceDirect, and Springer online databases and updates from the Indian Council of Medical Research (ICMR) were studied.

Conclusion:

Present review provides a comprehensive report on the association between plant polyphenols and lower risk of GDM, suggesting that polyphenol-rich dietary patterns may be important in preventing the development of GDM and its healthy management.
Çocuklarda pankreas hasarında COVID 19’un etkisi var mı?
Authors: Akyıldız Mustafa Yasir , Dindar Demiray Emine Kübra
Published: October 2021

Koronavirüs hastalığı 2019(COVID 19) etkilenen hasta sayısının artması ile birlikte hastalık farklı tutulumlarla karşımıza çıkmaktadır. Gastrointestinal (Gİ) tutulumlar da, gerek erişkinde gerek çocuklarda görülen atipik tutulumlardandır. Hatta bazı olgular, hiçbir pulmoner tutulum olmadan sadece Gİ tutulumla bile başvurabilmektedir. Çocuk vakalarda ilk zamanlarda hafif etkilenme olduğu bildirilmiş olsa da, artan sayıda komplike COVID 19 enfekte çocuk olgular da global olarak bildirilmeye başlamıştır. Bu derleme çalışmasında, çocuklarda pankreas hasarında COVID 19’un etkisinin litaretür eşliğinde gözden geçirilmesi amaçlandı.
Analyzing the practice of South Korea’s public diplomacy in Indonesia: An approach with communication pyramid of public diplomacy
Authors: Fitria Vita , Al Giffari Haekal Adha , Al Falah Daffa , Razin Muhammad Zul
Published: October 2021

The dissemination of South Korean culture in Indonesia becomes prominent as it attracts lot of people and creates many fans. The penetration of its spread in Indonesia is supported by some institutions which emphasizes on advocating and developing the South Korean culture and practice. The phenomena are not incidentally occurred, but it is well-managed by the government of South Korea as the advocate country of public diplomacy in collaboration with the target country which is Indonesia in achieving this mission. Public diplomacy is positioned as an approach of the advocate country to influence the public of foreign country to support the advocate’s country position which can be implemented through their state and non-sate actors in achieving mutual benefits. This paper observes the practice, impact, and challenges of South Korea’s public diplomacy in Indonesia based on Communication Pyramid Public Diplomacy framework. The findings show that the practice of public diplomacy allows cultural hybridity and increase enthusiasm of Indonesian in understanding the culture of the advocate country while the challenge is asymmetric direction between state and non-state actors of South Korea in the implementation of public diplomacy.
“Nomenclature changes, essence unchanged”: Peripheral prisons reform and refusal to alter deterrence for rehabilitation
Authors: Ajiboye Babatope Matthew , Awe Ene Norah , Akinyemi Olabambo Evelyn
Published: October 2021

The study focused on the Nigerian correctional institution and its mandate at rehabilitating convicts in preparedness for life outside bar and by implication reintegrating reformed individuals who are believed to pose no further threat to serenity of the society. Nigerian Correctional Service, previously known as Nigerian Prison Service, like its peer institution in the world, is primarily saddled with the responsibility to correct and reform convicts with the intent of reintegration back to conventional society. However, in Nigeria, this idea is render null and void with the broad-spectrum conception that when a person is sentenced to serve a jail term, that ultimately signifies the end of his or her worth in the society. Hence, the paper interrogates the Nigerian Correctional Service as an institution vested with the priority of making convicts better individuals. Emphasis was placed on the purported reformation of the institution in 2019. A secondary source was used for data collection and the content analytical approach was adopted which led to inferences drawn and logical conclusion established. The work reveals problems of welfare, infrastructural decay, and congestion coupled with pseudo rehabilitation obtainable in the institution. The study recommends that the Nigerian criminal justice system deserve an overhaul.
Alquran communication patterns and efforts to build positive communication
Authors: Sumarlan Iman , Firmansyah Rizki , Darmawan Hendra
Published: October 2021

Communication is an important matter in social life in building understanding and togetherness. This study aims to analyze the pattern of positive communication in the Alquran. This research paper uses a qualitative with analisys texts method, with a descriptive and interpretative approach to obtain clear information from the Alquran in communicating. Human relations are not built properly if they ignore the values and main aspects of communicating, namely honesty, truth, and clarity. All aspects that in recent years have diminished and may have disappeared. Alquran as a holy book contains kalamullah as a form of communication to humans which is loaded with various communication messages so that it can be used as a guide for humans to interact because the Alquran presents an ideal picture in communicating. This study uses a qualitative approach with a analisys teks method from the book of commentaries and sources with other similar topics.
A Self-help Tool to Facilitate Implementation of eHealth Initiatives in Health Care (E-Ready): Formative Evaluation
Authors: Dannapfel Petra , Thomas Kristin , Chakhunashvili Alexander , Melin Jeanette , Trolle Lagerros Ylva
Published: October 2021

Background

eHealth interventions have the potential to increase the efficiency and effectiveness of health care. However, research has shown that implementing eHealth in routine health care practice is difficult. Organizational readiness to change has been shown to be central to successful implementation. This paper describes the development and formative evaluation of a generic self-help tool, E-Ready, designed to be used by managers, project leaders, or others responsible for implementation in a broad range of health care settings.

Objective

The aim of this study is to develop and evaluate a tool that could facilitate eHealth implementation in, for example, health care.

Methods

A first version of the tool was generated based on implementation theory (E-Ready 1.0). A formative evaluation was undertaken through expert panels (n=15), cognitive interviews (n=17), and assessment of measurement properties on E-Ready items from 3 different workplaces (n=165) using Rasch analyses. E-Ready 1.0 was also field tested among the target population (n=29). Iterative revisions were conducted during the formative evaluation process, and E-Ready 2.0 was generated.

Results

The E-Ready Tool consists of a readiness assessment survey and a hands-on manual. The survey measures perceived readiness for change (willingness and capability) at individual and collective levels: perceived conditions for change at the workplace, perceived individual conditions for change, perceived support and engagement among management, perceived readiness among colleagues, perceived consequences on status quo, and perceived workplace attitudes. The manual contains a brief introduction, instructions on how to use the tool, information on the themes of E-Ready, instructions on how to create an implementation plan, brief advice for success, and tips for further reading on implementation theory. Rasch analyses showed overall acceptable measurement properties in terms of fit validity. The subscale Individual conditions for change (3 items) had the lowest person reliability (0.56), whereas Perceived consequences on status quo (5 items) had the highest person reliability (0.87).

Conclusions

E-Ready 2.0 is a new self-help tool to guide implementation targeting health care provider readiness and engagement readiness ahead of eHealth initiatives in, for example, health care settings. E-Ready can be improved further to capture additional aspects of implementation; improvements can also be made by evaluating the tool in a larger sample.
Identifying Frequent Health Care Users and Care Consumption Patterns: Process Mining of Emergency Medical Services Data (Preprint)
Authors: Maruster Laura , van der Zee Durk-Jouke , Buskens Erik
Published: October 2021

BACKGROUND

Tracing frequent users of health care services is highly relevant to policymakers and clinicians, enabling them to avoid wasting scarce resources. Data collection on frequent users from all possible health care providers may be cumbersome due to patient privacy, competition, incompatible information systems, and the efforts involved.

OBJECTIVE

This study explored the use of a single key source, emergency medical services (EMS) records, to trace and reveal frequent users’ health care consumption patterns.

METHODS

A retrospective study was performed analyzing EMS calls from the province of Drenthe in the Netherlands between 2012 and 2017. Process mining was applied to identify the structure of patient routings (ie, their consecutive visits to hospitals, nursing homes, and EMS). Routings are used to identify and quantify frequent users, recognizing frail elderly users as a focal group. The structure of these routes was analyzed at the patient and group levels, aiming to gain insight into regional coordination issues and workload distributions among health care providers.

RESULTS

Frail elderly users aged 70 years or more represented over 50% of frequent users, making 4 or more calls per year. Over the period of observation, their annual number and the number of calls increased from 395 to 628 and 2607 to 3615, respectively. Structural analysis based on process mining revealed two categories of frail elderly users: low-complexity patients who need dialysis, radiation therapy, or hyperbaric medicine, involving a few health care providers, and high-complexity patients for whom routings appear chaotic.

CONCLUSIONS

This efficient approach exploits the role of EMS as the unique regional “ferryman,” while the combined use of EMS data and process mining allows for the effective and efficient tracing of frequent users’ utilization of health care services. The approach informs regional policymakers and clinicians by quantifying and detailing frequent user consumption patterns to support subsequent policy adaptations.

CLINICALTRIAL
How should physicians set prices for individual service and team-based service in the online environment? A view from the price difference (Preprint)
Authors: Lu Wei , Wei Wei , Li Chao , Luo Qing , Fan Lichun
Published: October 2021

BACKGROUND

Price which has a significant effect on consumers’ exchanging value perception plays a decisive role in the product market. Different from the traditional medical market, the online medical market allows physicians considerable discretion in setting prices of their services, which begin to be paid close attention to. Physicians face a challenge with the introduction of various service styles. Some studies have begun to examine the role of price in the online medical service environment, however, limited studies have explored them in both individual and team-based contexts.

OBJECTIVE

Guided by transaction utility theory and price fairness, this study aims to investigate the influence of pricing strategy on service demands from the price difference perspective by focusing on two typical service models: individual service and team-based service. Moreover, team characteristics (response speed and team size) are also considered.

METHODS

The data collection was conducted in March 2018 and repeated in May 2018, and physicians who provide both individual service and team-based service are included in our study. Finally, a dataset consisting of 1,100 teams with 1,100 physician leaders from 14 departments such as obstetrics and gynaecology department were collected from an online medical platform in China were included.

RESULTS

Empirical results support most of our hypotheses. A negative influence of team-based price has been got (β = -0.282, p < 0.000). As a substitute service, higher individual service price will make patients turn to the team-based service (β = 0.164, p < 0.000). Moreover, individual service price negatively moderates the relationship between team-based service price and demands (β = -0.036, p < 0.05). By calculating the price difference between individual service price and team-based service price, we find a negative role of the price difference in affecting patient purchase decisions (β = -0.085, p < 0.05). Although we did not find a significant effect of team size, a quick response can attract more patients (β = 0.174, p = 0.05).

CONCLUSIONS

Price fairness provides a proper framework for understanding pricing strategy in individual and team-based service in an online environment. Understanding the effects of prices from a price difference perspective has both theoretical and practical contributions. Specifically, this study contributes to knowledge on price fairness, online medical platforms, and virtual teams, and provides management suggestions.
Development and validation of a deep learning system for comprehensive imaging quality check to classify body parts and contrast enhancement (Preprint)
Authors: Na Seongwon , Sung Yusub , Ko Yousun , Shin Youngbin , Lee Junghyun , Ha Jiyeon , Ham Sujung , Yoon Kyoungro , Kim Kyung Won
Published: October 2021

BACKGROUND

Despite the dramatic increase in the use of medical imaging in various therapeutic fields of clinical trials, image quality check is still performed manually by image analysts, which requires a lot of manpower and time.

OBJECTIVE

This study aimed to develop a deep learning model that simultaneously identifies anatomical locations and contrast enhancement on medical images, with accuracy and clinical effectiveness validation, to support an automated image quality check.

METHODS

In this retrospective study, 1,669 computed tomography (CT) images with five specific anatomical locations were collected from Asan Medical Center and Kangdong Sacred Heart Hospital. To generate the ground truth, two radiologists reviewed the anatomical locations and presence of contrast enhancement using the collected data. A deep learning framework called ImageQC-net (Image Quality Check-network) with transfer learning was developed using an InceptioResNetV2 model. To evaluate their clinical effectiveness, the overall accuracy and time spent on image quality check of a conventional model and ImageQC-net were compared.

RESULTS

The ImageQC-net body part classification showed an excellent performance in both internal (precision, 100%; recall, 100%; and accuracy, 100%) and external validation sets (precision, 99.34%; recall, 99.33%; and accuracy, 99.33%). In addition, the contrast-enhanced classification performance achieved 100% precision, recall, and accuracy in the internal validation set and ~100% accuracy in the external dataset (precision, 99.76%; recall, 99.79%; and accuracy, 99.78%). When integrating the model that achieved the best performance, the overall accuracy was 99.1%. For clinical effectiveness, the time reduction by artificial intelligence (AI)-aided quality check of both analyst 1 and 2 (49.7% and 48.3% decrease, respectively) was statistically significant (p < 0.001).

CONCLUSIONS

Comprehensive AI techniques to identify body parts and contrast enhancement on CT images are highly accurate and can significantly reduce the time spent on image quality checks.
Toward More Inclusive Networks and Initiatives in Innovation Ecosystems: Protocol for a Systematic Review (Preprint)
Authors: Ntina Georgia , Mavromanolaki Eirini , Flouris Andreas D
Published: October 2021

BACKGROUND

Expanding the cooperation and enlarging the participation of more diverse stakeholders within innovation ecosystems will increase their efficiency and capacity to contribute at local, regional, and national levels.

OBJECTIVE

This paper presents the protocol for a systematic review that will identify “opening-up” strategies of innovation ecosystems for increasing the participation of more diverse innovation stakeholders, particularly from low-innovation countries, during the ecosystem formation period.

METHODS

An algorithmic search in 4 databases (Web of Science, Cochrane Library, Scopus, and Social Science Research Network) will be applied based on the PerSPecTIF (perspective, setting, phenomenon of interest/problem, environment, optional comparison, time/timing, and findings) methodology, the Cochrane guidelines for qualitative evidence synthesis, and the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Selection criteria for eligibility include peer-reviewed articles published after December 31, 1999, and containing original data. No restrictions will be placed on the article language and study region, design, or methodology. Methodological strengths and limitations will be assessed using the Critical Appraisal Skills Programme tool. The thematic synthesis method will be adopted, and the GRADE-CERQual tool will be used to assess confidence.

RESULTS

A preliminary search in Web of Science revealed 2758 records. This work is part of the ANGIE project, which was funded by the European Union’s Horizon 2020 research and innovation program (grant 952152) in January 2021. We anticipate that the results of this systematic review will be published in spring 2022.

CONCLUSIONS

We anticipate that the outcomes of this systematic review will outline the best practices used by initiatives and networks, as well as their impacts on creating larger and more inclusive ecosystems.

CLINICALTRIAL

OSF Registries osf.io/hc62k 10.17605/OSF.IO/HC62K

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/34071
Parameters of cardiac hemodynamics in patients with diabetes mellitus with impairment of renal function
Authors: Topchiy I.I. , Kirienko O.N. , Semyonovykh P.S. , Kirienko D.O. , Tsygankov O.I. , Gridasova L.M.
Published: October 2021

Currently, diabetes mellitus (DM) is a complex global problem, which is increasing every year. So, in 2019, diabetes mellitus was detected in 463 million adults (from 20 to 79 years old) in the world. And the main cause of death in patients with diabetes mellitus is cardiovascular complications. The study was aimed investigate the features of functional and structural changes in the heart in patients with type 2 diabetes mellitus and nephropathy. A total of 98 patients with type 2 diabetes mellitus were examined, out of which 78 patients had diabetic nephropathy (DN) of varying severity. The control group consisted of 20 healthy patients. After a clinical examination, depending on the state of renal function, all patients were divided into the following groups: group I — patients with type 2 diabetes mellitus without signs of nephropathy (n = 36), group II — patients with type 2 diabetes mellitus with normal glomerular filtration rate (GFR) and albuminuria (n = 33), group III — patients with type 2 diabetes mellitus with decreased GFR and albuminuria (n = 29). To study changes in hemodynamics and structural parameters of the heart, patients underwent transthoracic echocardiography on an ULTIMA PA ultrasound machine (Radmir, Ukraine) using a sectoral phased transducer with a frequency range of 2–3 MHz according to the standard technique based on the recommendations of the American Echocardiographic Society. To determine indexing indicators, the patients underwent anthropometric measurements. Patients with DN and albuminuria and decreased GFR showed an increase in the linear dimensions of the heart in comparison with controls and patients without signs of nephropathy. With DN, patients have a significant increase in left ventricular mass and a significant increase in the detection rate of left ventricular hypertrophy up to 91.3 % in patients with albuminuria and preserved renal function and up to 100 % with a decrease in GFR.
The Unemployment Rate Amid the COVID-19 Pandemic: Propose the Best Practices Policy to Maintain Labor Market Stability
Authors: Malik Nazaruddin , Suliswanto Muhammad Sri Wahyudi , Rofik Mochamad
Published: October 2021

This study analyzes the impact of the shocks caused by the COVID-19 pandemic on the labor market. The research is vital for expanding the literature about maintaining the unemployment rate amid crisis, ultimately reducing unnecessary social costs. The quantitative approach in this study uses a Granger causality test to understand the effect of the shock caused by the COVID-19 pandemic on unemployment. Meanwhile, the qualitative approach in this study uses literature related to economic growth, crisis management, and unemployment. Granger causality tests show that economic slowdown hurts the unemployment rate. Based on discussion and synthesis from works of literature, this paper recommends some of the policies to maintain growth and prevent a more severe collapse in the labor market; the government needs to sustain aggregate demand and supply. Also, ensure the supply chain runs well amid various restrictions. Besides, this paper also proposes that the government maximizes alternative budget resources. Meanwhile, strengthening the labor system and developing health and food security industries must be a priority policy amid-post the pandemic.
COMBINING THE SUITABILITY-FEASIBILITY-ACCEPTABILITY (SFA) STRATEGY WITH THE MCDM APPROACH
Authors: Hashemkhani Zolfani Sarfaraz , Bazrafshan Ramin , Akaberi Parnian , Yazdani Morteza , Ecer Fatih
Published: October 2021

Suitability-Feasibility-Acceptability (SFA) is a fundamental tool for the development and selection of strategy. Any type of decision-making problem can be resolved by Multiple Criteria Decision Making (MCDM) methods. In this research, we explore the complexity of determining the proper goal market for the Chilean fish market. This study proposed a combined approach of SFA with MCDM methods in a real case study. The proposed structure helps to assign the best market for Chilean export fish to West Asia. Three countries (Saudi Arabia, the United Arab Emirates, and Oman) are selected as a target market in this region, and then related criteria are obtained from various sources. In order to develop a new market for the Chilean fishery industry, five major criteria, including the potential of a target market, region's economic attractiveness, consumption of the seafood, location, cost of transportation, and country risks, were selected based on the SFA framework. Calculating the criteria weights is performed by the Best-Worst (BWM) method, and ordering the alternatives is operated by Measurement Alternatives and Ranking according to compromise Solution (MARCOS) methods. The results showed that Oman is the best destination (importer) for the Chilean fish market (Salmon fish as the case).
dimensão aurática das imagens-sonho no tarô e nas histórias em quadrinhos – estudo das tiras de Gasoline Alley
Authors: Inácio Marcondes Ciro , Dravet Florence
Published: October 2021

As imagens do tarô, assim como as dos quadrinhos, são arquetípicas e apelam para uma razão poética atuante nas brechas entre elas, convidando o leitor a constantes exercícios de montagens e remontagens narrativas. A partir dos estudos da imagem de Warburg e Didi-Huberman adentramos a poeticidade dessas imagens que consideramos imagens-sonho dotadas de potência aurática imaginante. Também recorremos ao conceito de razão poética proposto por Zambrano. A análise de tiras Gasoline Alley, de Frank King, ampara nossa proposta. Concluímos que os saberes imagéticos do tarô baseiam-se em uma linguagem que ultrapassa códigos e sistemas de significação, estendendo seu alcance a uma potência latente, atuante na dimensão aurática das imagens-sonho. Dimensão também presente nas imagens dos quadrinhos, cuja teorização permite abrir-se a competências imaginativas.
Imagens de um devir-animal: entre literatura e ilustração no conto “Conversa de bois”, de Guimarães Rosa
Authors: Pereira de Freitas Gabriela , Novakoski Carvalho Rhaysa
Published: October 2021

Tendo em vista o questionamento “como o devir estabelece a relação híbrida entre ilustração e palavra no conto ‘Conversa de bois’, de Guimarães Rosa”, este artigo levanta reflexões sobre e a partir de certo indiscernimento entre imagens sensíveis e visíveis, que tanto emanam mentalmente do texto quanto o acompanham como ilustração literária visível. Com plano de fundo tecido por meio dos conceitos de Krauss e Bellour sobre campo expandido e relações híbridas entre imagem e literatura, aqui se desencadeia uma caminhada por algumas apreensões sobre o tema, em um devaneio que evoca e relaciona imagens para entender um devir-palavra e um devir-escritor-feiticeiro submersos em uma aura de mistério. O imaginário de feiticeiro e as simbologias do boi, são, também, chaves interpretativas que relacionam o conto e o livro rosiano como objeto aos conceitos de feitiçaria e devir-animal, de Deleuze e Guattari.
Sobre fake news e fake History
Authors: Souza Rosali Fernandez de , Aldeia Duarte Rodrigo
Published: October 2021

Este trabalho apresenta a tradução para português de uma compilação de palestras do professor Jason Steinhauer sobre o tema das fake news e seu correlato, a fake History, conceito criado pelo autor para dar conta da força com que o obscurantismo tem atingido e moldado a visão sobre o passado e a competência em História do público em geral. O artigo analisa correlações entre as duas questões, que enfraquecem sobremaneira a capacidade do público de distinguir informações falsas das reais, e propõe uma estratégia comunicacional proativa por parte dos historiadores, a comunicação histórica, elemento vital para o combate ao discurso falseador e anticientífico presente nos principais meios de divulgação – especialmente nas novas tecnologias, portais de notícias e mídias sociais – que associa acriticamente História e passado.
Desinformação, antivacina e políticas de morte: o mito (d)e virar jacaré
Authors: Soares Bezerra Josenildo , Da Silva Penha Magno Madja Elayne , Toscano Maia Carolina
Published: October 2021

Neste artigo propomos uma reflexão sobre como a desinformação (WARDLE; DERAKSHAN, 2017) e os movimentos antivacina (VASCONCELLOS-SILVA; CASTIEL, 2020) dificultam o combate à pandemia da Covid-19, principalmente quando chancelados por agentes públicos, dada a sua visibilidade e influência na esfera social (SOARES JÚNIOR, 2020; RECUERO et. al., 2021). Assim, analisamos o pronunciamento do presidente da república, Jair Bolsonaro, em que associa a vacinação contra a doença ao mito de virar jacaré. Entendendo o discurso a partir de sua materialidade discursiva, utilizamos uma perspectiva foucaultiana (FOUCAULT, 2001; 2005; 2008; 2014), em uma vertente biopolítica e de seus dispositivos de segurança.
A “vacina chinesa de João Doria”: a influência da disputa política-ideológica na desinformação sobre a vacinação contra a Covid-19
Authors: Pontalti Monari Ana Carolina , Sacramento Igor
Published: October 2021

Este artigo analisa a influência das disputas políticas e ideológicas na desinformação sobre a vacinação contra a Covid-19 no WhatsApp. Por meio das estratégias discursivas de legitimação para o conteúdo desinformativo (SOARES et al., 2021b), foram investigados nove vídeos que circularam no aplicativo de mensagens entre 30 de novembro de 2020 e 30 de janeiro de 2021 para compreender 1) quais seriam as características sobre a vacina contra Covid-19 que circularam no aplicativo durante o período e 2) de que forma o discurso político-ideológico influenciou os conteúdos desinformativos sobre o imunizante. Em nosso estudo, observou-se que a desinformação sobre a vacinação contra a Covid-19 opera por meio de teorias da conspiração que se utilizam, sobretudo, de autoridades médicas para validar o seu discurso.
Desafios e estratégias no combate à desinformação na Pandemia: análise da cobertura telejornalística do caso Epcar em Barbacena
Authors: Thomé Cláudia , Soares de Morais Luciana , Campos Ana Carolina
Published: October 2021

No contexto de negacionismo e informações veladas durante a pandemia da Covid-19, o presente artigo traz uma análise da cobertura audiovisual no telejornalismo regional do MG1 e MG2 - Zona da Mata, da TV Integração acerca de um caso em Barbacena, Minas Gerais, envolvendo a Escola Preparatória de Cadetes do Ar (Epcar), entre maio e julho de 2020. O trabalho mostra essa guerra informacional e reflete sobre qual é o papel do jornalismo no combate às fake news e na divulgação de informações no período pandêmico, além de reforçar que, por meio dele, é possível transferir conhecimento acerca do que se passa no mundo. Além disso, o artigo mostrou como o jornalismo se torna uma importante ferramenta em um período de fortes práticas negativistas, cujas ações podem impactar na saúde coletiva. A análise adotou a metodologia de Análise da Materialidade Visual (COUTINHO, 2016).
Analisis Risiko Kesehatan Lingkungan Paparan Nitrogen Dioksida (NO2) Pada Penyapu Jalan di Kota Jambi Tahun 2021
Authors: Izzati Cindy , Noerjoedianto Dwi , Siregar Sri Astuti
Published: October 2021

Nitrogen Dioksida (NO2) masuk kedalam pencemar yang dihasilkan dari berbagai sumber di suatu lingkungan paling utama zona transportasi. Sebagai gambaran umum, zona transportasi ialah penyumbang polutan NO2 sebesar 69% di perkotaan, berikutnya perindustrian serta rumah tangga. Kelompok yang berpotensi besar terserang akibat polusi udara ialah warga yang kerap berlalu-lalang di jalan raya, warga yang bertempat tinggal di tepi jalan raya, maupun warga yang bekerja di dekat jalan raya, satu antara lain adalah pekerja Penyapu Jalan. Desain studi penelitian ini menggunakan metode analisis risiko kesehatan lingkungan (ARKL). Metode ARKL digunakan untuk mengetahui besarnya risiko kesehatan akibat paparan Nitrogen Dioksida (NO2) terhadap Penyapu Jalan di Kota Jambi tahun 2021. Hasil penelitian didapatkan bahwa tingkat risiko realtime Penyapu Jalan pada saat penelitian dilakukan pada titik 1 – titik 4 maksimal sebesar 0,0706487. Hasil tersebut seluruhnya menunjukkan nilai RQ yang kurang dari satu (RQ < 1). Untuk lifespan atau pajanan 30 tahun kedepan pada titik 1 – titik 4 maksimal sebesar 0,1513901. Kesimpulan dari penelitian ini artinya saat ini Penyapu jalan di Kota Jambi masih aman berada di lokasi penelitian dalam 7 jam/hari, 365 hari/tahun dan Penyapu jalan di Kota Jambi tetap aman selama maksimal 30 tahun mendatang.Kata Kunci: Analisis Risiko Kesehatan Lingkungan, Nitrogen Dioksida (NO2), Penyapu Jalan
Hubungan Lingkungan Fisik Rumah dengan Kejadian Pneumonia pada Balita di Wilayah Kerja Puskesmas Plumbon
Authors: Akbar Hairil , B Hamzah , Hamzah St. Rahmawati , Paundanan Matius , Reskiaddin La Ode
Published: October 2021

Pneumonia merupakan salah satu penyakit infeksi saluran pernapasan akut bagian bawah yang menjadi penyebab utama morbiditas dan mortalitas anak berusia dibawah lima tahun terutama di negara yang sedang berkembang. Tujuan penelitian ini untuk mengetahui hubungan jenis lantai rumah dan jenis dinding rumah dengan kejadian pneumonia pada balita di wilayah kerja Puskesmas Plumbon. Jenis penelitian yang digunakan observasional analitik dengan rancangan cross sectional dengan jumlah sampel sebanyak 43 responden. Teknik penarikan sampel yang digunakan adalah Acidental Sampling. Data dikumpulkan dengan wawancara langsung kepada responden dan dianalisis secara univariat dan bivariat dengan menggunakan uji chi square. Hasil penelitian menunjukkan bahwa terdapat 62,8% responden yang mempunyai balita menderita pneumonia, 44,2% responden yang memiliki jenis lantai rumah yang tidak memenuhi syarat kesehatan dan terdapat 51,2% resespon yang memiliki jenis dinding rumah yang tidak memenuhi syarat kesehatan. Hasil uji statistik diperoleh ada hubungan antara jenis lantai rumah dengan kejadian pneumonia pada balita (p = 0,010 < 0,05) dan ada hubungan antara jenis dinding rumah dengan kejadian pneumonia pada balita (p = 0,008 < 0,05) di wilayah kerja Puskesmas Plumbon. Kesimpulan dari dua variabel ada hubungan antara jenis lantai rumah dan jenis dinding rumah dengan kejadian pneumonia pada balita di wilayah kerja Puskesmas Plumbon.Kata Kunci: Lantai, Dinding, Pneumonia, Balita
Effect of casting and rolling process parameters on solidification welding line of magnesium alloy
Authors: Huang Z. , Lai H.-Y. , Zhou H.-B. , Guo H.
Published: October 2021

Process of horizontal twin roll casting magnesium alloy was analyzed by numerical simulation. Taking solidification welding line in cast rolling area as research object, the characteristic change of solidification welding line caused by casting rolling temperature, casting rolling speed, and roll heat transfer capacity and its influence on the forming process of casting rolling area were analyzed. The results show that increasing casting temperature, casting speed or reducing heat transfer capacity of roll can make solidification welding line shift to exit of casting rolling zone. Increasing casting temperature and casting speed will increase difference between middle and edge of the solidification welding line along casting direction and heat distribution of whole slab is more uniform. However, effect of improving heat transfer capacity of roll is completely opposite. According to this, optimum process parameters of casting and rolling magnesium alloy with plate thickness of 6 mm are put forward to reduce probability of edge crack.