bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrogen Sulfide Detection in the Midinfrared Using a 3D-Printed Resonant Gas Cell
Authors: Bonilla-Manrique Oscar E. , Moser Harald , Martín-Mateos Pedro , Lendl Bernhard , Ruiz-Llata Marta
Published: March 2019

A fast and reliable photoacoustic (PA) sensor for trace gas detection is reported. The sensor is based on a 3D-printed resonant cell in combination with a continuous wave mode-hop-free external cavity quantum cascade laser to rapidly acquire gas absorption data in the midinfrared range. The cell is designed so as to minimize the window PA background at a selected acoustic resonance. The goal is a resonant PA cell capable of detecting the traces of gases using wavelength modulation of the laser source and second harmonic detection. The versatility and enhancement of the limit of detection at sub-ppm levels are investigated by monitoring specific lines of hydrogen sulfide (H2S). The noise-equivalent absorption normalized to laser-beam power and detection bandwidth is 1.07×10-8 W cm-1 Hz-1/2 for H2S targeting the absorption line at 1247.2 cm−1. These properties make the sensor suitable for various practical sensors for water quality applications.
miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair–Deficient Colorectal Cancer by Targeting PD-L1
Authors: Ashizawa Mai , Okayama Hirokazu , Ishigame Teruhide , Thar Min Aung Kyi , Saito Katsuharu , Ujiie Daisuke , Murakami Yuko , Kikuchi Tomohiro , Nakayama Yuko , Noda Masaru , Tada Takeshi , Endo Hisahito , Fujita Shotaro , Sakamoto Wataru , Saito Motonobu , Saze Zenichiro , Momma Tomoyuki , Ohki Shinji , Mimura Kosaku , Kono Koji
Published: March 2019

Immunotherapy against the interaction between programmed cell death 1/programmed cell death ligand 1 (PD-L1) has emerged as a promising strategy for colorectal cancer with mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H). The study aimed to identify miRNAs that posttranscriptionally control PD-L1 expression on tumor cells and also regulate immune evasion. A comprehensive miRNA screening using The Cancer Genome Atlas (TCGA) dataset (n = 260) combined with eight different miRNA target prediction programs resulted in the identification of a tumor suppressive miRNA, miR-148a-3p, as a potential negative regulator of PD-L1 expression, particularly in dMMR/MSI-H colorectal cancer. Using multiple cohorts of colorectal cancer, including TCGA data, a microarray dataset (n = 148), and formalin-fixed, paraffin-embedded samples (n = 395), we found that the expression of miR-148a-3p was decreased in dMMR/MSI-H tumors, correlating inversely with PD-L1 levels. We demonstrate that miR-148a-3p directly binds to the 3′-untranslated region of PD-L1, thereby reducing whole-cell and cell surface PD-L1 levels in HCT116 and SW837 cell lines. Overexpression of miR-148a-3p repressed IFNγ-induced PD-L1 expression on tumor cells and consequently diminished T-cell apoptosis in a coculture model of IL2-activated T cells and IFNγ-treated tumor cells. In conclusion, our data support a regulatory mechanism of PD-L1 expression on tumor cells and immune suppression via miR-148a-3p downregulation in colorectal cancer.

Implications:

This study provides novel evidence that miR-148a-3p negatively regulates tumor cell PD-L1 expression and decreased levels of miR-148a-3p contributes to the immunosuppressive tumor microenvironment.
Processos de formação em saúde
Authors: Muniz Hélder Pordeus , Barros Maria Elizabeth Barros de , Neves Cláudia Elizabeth Abbês Baêta
Published: March 2019

Este ensaio tem por objetivo discutir os desafios na formação de trabalhadoras de saúde sob a estratégia da educação a distância (EaD). Avalia-se a aposta num trabalho em que a experiência, enquanto narrativa de um conhecimento acumulado por gerações, nos torna tanto parte da história quanto abertura ao devir. A metodologia utilizada foi a análise das experiências de trabalhadores e trabalhadoras do Sistema Único de Saúde (SUS), a partir de relatos e situações vivenciadas. Indica como resultado a potência da EaD nos processos formativos − o alcance extensivo desses processos − bem como seus limites no que tange à visualização da emoção, da expressão corporal e da produção de sentido do discurso. Conclui-se que a comunicação virtual permitiu a cooperação de profissionais de diferentes municípios, a despeito de os encontros presenciais terem sido imprescindíveis à construção de diretrizes éticas para o trabalho em comum.
Appropriating the Trinity for an Inclusive Christian Vision on Development
Authors: Lin Peirong
Published: March 2019

In this article, an inclusive Christian vision for the development sector is sketched. A clearer understanding of the Christian vision is useful to guide Christian development institutions as they deliberate their priorities in the broader development sector. This vision appropriates the Trinity, a core Christian doctrine that is included in all Christian orthodox traditions. It focuses on the revelation of God in this world and the understanding of the missio Dei. The article clarifies the particular way that development institutions participate in this mission, through social justice. Justice is understood as the pursuing of the wellbeing of the other in light of God’s love. For a fuller understanding of God’s love, the way that each divine person clarifies the understanding of social justice, and therefore the subsequent development sector, is outlined.
Strobilomyces minor (Boletaceae), a new species associated with fagaceous plants in Central China
Authors: HAN LI-HONG , ZHAO KUAN , LIU CHAO , CHU HONG-LONG , TANG LI-ZHOU
Published: March 2019

A new species, Strobilomyces minor, associated with host plants of Fagaceae, is introduced based on morphological and molecular studies. Strobilomyces minor is characterized by its small basidiomes, light yellowish brown appressed pyramidal scales on the pileus and stipe, large hymenophoral pores, and reticulate basidiospores with large meshes. Maximum Likelihood and Bayesian analyses based on four gene markers (rpb1, rpb2, tef1 and cox3) as well as morphological characters confirmed that this new taxon belongs to Strobilomyces and it is distinct from any known species. A morphological description with line drawings and SEM images for the species is provided.
Scrophularia vernalis: a new species record for Turkey, and its comparison with S. chrysantha (Scrophulariaceae)
Authors: UZUNHİSARCIKLI MEHMET ERKAN , DOĞAN GÜNER EBRU , ÖZBEK FUNDA , EKİCİ MURAT
Published: March 2019

Scrophularia vernalis (Scrophulariaceae) is recorded from Artvin province (NE of Turkey), which constitutes its first record for the Turkish flora. In this study, an expanded morphological description, geographical distribution, habitat characteristics and ecological features of the species are shown with illustrative figures. Moreover, the pollen and seed morphological characteristics of S. vernalis are determined for the first time and compared with the closely related species S. chrysantha. With this species, the total number of the Scrophularia taxa in Turkey is now 77.
A New Parameter to Assess Impact of Rain Gauge Density on Uncertainty in the Estimate of Monthly Rainfall over India
Authors: Prakash Satya , Seshadri Ashwin , Srinivasan J. , Pai D. S.
Published: March 2019

Rain gauges are considered the most accurate method to estimate rainfall and are used as the “ground truth” for a wide variety of applications. The spatial density of rain gauges varies substantially and hence influences the accuracy of gridded gauge-based rainfall products. The temporal changes in rain gauge density over a region introduce considerable biases in the historical trends in mean rainfall and its extremes. An estimate of uncertainty in gauge-based rainfall estimates associated with the nonuniform layout and placement pattern of the rain gauge network is vital for national decisions and policy planning in India, which considers a rather tight threshold of rainfall anomaly. This study examines uncertainty in the estimation of monthly mean monsoon rainfall due to variations in gauge density across India. Since not all rain gauges provide measurements perpetually, we consider the ensemble uncertainty in spatial average estimation owing to randomly leaving out rain gauges from the estimate. A recently developed theoretical model shows that the uncertainty in the spatially averaged rainfall is directly proportional to the spatial standard deviation and inversely proportional to the square root of the total number of available gauges. On this basis, a new parameter called the “averaging error factor” has been proposed that identifies the regions with large ensemble uncertainties. Comparison of the theoretical model with Monte Carlo simulations at a monthly time scale using rain gauge observations shows good agreement with each other at all-India and subregional scales. The uncertainty in monthly mean rainfall estimates due to omission of rain gauges is largest for northeast India (~4% uncertainty for omission of 10% gauges) and smallest for central India. Estimates of spatial average rainfall should always be accompanied by a measure of uncertainty, and this paper provides such a measure for gauge-based monthly rainfall estimates. This study can be further extended to determine the minimum number of rain gauges necessary for any given region to estimate rainfall at a certain level of uncertainty.
The effect of pulsating throughflow on the onset of magneto convection in a layer of nanofluid confined within a Hele-Shaw cell
Authors: Yadav Dhananjay
Published: March 2019

In this article, the joint effect of pulsating throughflow and magnetic field on the onset of convective instability in a nanofluid layer, bounded in a Hele-Shaw cell is presented within the context of linear stability theory and frozen profile approach. The model utilized for nanofluid combines the impacts of Brownian motion and thermophoresis, while for Hele-Shaw cell, Hele-Shaw model is considered. The Galerkin technique is utilized to solve the eigenvalue problem. The outcome of the important parameters on the stability framework is examined analytically. It is observed that the pulsating throughflow and magnetic field have both stabilizing effects. The impact of increasing the Hele-Shaw number [Formula: see text], the modified diffusive ratio [Formula: see text] and the nanoparticle Rayleigh number [Formula: see text] is to quicken the convective motion, while the Lewis number [Formula: see text] has dual impact on the stability framework in the existence of pulsating throughflow. It is also established that the oscillatory mode of convective motion is possible only when the value of the magnetic Prandtl number [Formula: see text] is not greater than unity.
Impact of Race and Ethnicity on End-of-Life Experiences for Children With Cancer
Authors: Kaye Erica C. , Gushue Courtney A. , DeMarsh Samantha , Jerkins Jonathan , Li Chen , Lu Zhaohua , Snaman Jennifer M. , Blazin Lindsay , Johnson Liza-Marie , Levine Deena R. , Morrison R. Ray , Baker Justin N.
Published: March 2019

Background:

Racial and ethnic disparities in the provision of end-of-life care are well described in the adult oncology literature. However, the impact of racial and ethnic disparities at end of life in the context of pediatric oncology remains poorly understood.

Objective:

To investigate associations between end-of-life experiences and race/ethnicity for pediatric patients with cancer.

Methods:

A retrospective cohort study was conducted on 321 children with cancer enrolled on a palliative care service at an urban pediatric cancer who died between 2011 and 2015.

Results:

Compared to white patients, black patients were more likely to receive cardiopulmonary resuscitation (CPR; odds ratio [OR]: 4.109, confidence interval [CI]: 1.432-11.790, P = .009) and underwent 3.136 (CI: 1.433-6.869, P = .004) CPR events for every 1 white patient CPR event. The remainder of variables related to treatment and end-of-life care were not significantly correlated with race. Hispanic patients were less likely to receive cancer-directed therapy within 28 days prior to death (OR: 0.493, CI: 0.247-0.982, P = .044) as compared to non-Hispanic patients, yet they were more likely to report a goal of cure over comfort as compared to non-Hispanic patients (OR: 3.094, CI: 1.043-9.174, P = .042). The remainder of variables were not found to be significantly correlated with ethnicity.

Conclusions:

Race and ethnicity influenced select end-of-life variables for pediatric palliative oncology patients treated at a large urban pediatric cancer center. Further multicenter investigation is needed to ascertain the impact of racial/ethnic disparities on end-of-life experiences of children with cancer.
The crystal structure of Ni-rich gordaite–thérèsemagnanite from Cap Garonne, France
Authors: Mills Stuart J. , Missen Owen P. , Favreau Georges
Published: March 2019

The crystal structure of Ni-rich gordaite–thérèsemagnanite has been determined from a sample collected at pillar 80 in the North mine, Cap Garonne, Var, France. The structure was refined toR1= 0.0693 for 935 reflections withI> 2σ(I). The mineral is isostructural with gordaite, forming a layered structure with an extensive hydrogen-bonding network. The possible polytypic relationship between gordaite, thérèsemagnanite and guarinoite is also discussed. The guarinoite formula (Zn,Co,Ni)6(SO4)(OH,Cl)10·5H2O is also likely to be incorrect and is more likely to be Na(Zn,Co)4(SO4)(OH)6Cl·5–6H2O, meaning that guarinoite is equivalent to Co-rich gordaite-2Hand would not be a distinct mineral species.
Regulation of fiber-specific actin expression by the Drosophila SRF ortholog Blistered
Authors: DeAguero Ashley A. , Castillo Lizzet , Oas Sandy T. , Kiani Kaveh , Bryantsev Anton L. , Cripps Richard M.
Published: March 2019

Serum response factor (SRF) has an established role in controlling actin homeostasis in mammalian cells, yet its role in non-vertebrate muscle development has remained enigmatic. Here, we demonstrate that the single Drosophila SRF ortholog, termed Blistered (Bs), is expressed in all adult muscles, but Bs is required for muscle organization only in the adult indirect flight muscles. Bs is a direct activator of the flight muscle actin gene Act88F, via a conserved promoter-proximal binding site. However, Bs only activates Act88F expression in the context of the flight muscle regulatory program provided by the Pbx and Meis orthologs Extradenticle and Homothorax, and appears to function in a similar manner to mammalian SRF in muscle maturation. These studies place Bs in a regulatory framework where it functions to sustain the flight muscle phenotype in Drosophila. Our studies uncover an evolutionarily ancient role for SRF in regulating muscle actin expression, and provide a model for how SRF might function to sustain muscle fate downstream of pioneer factors.
mTOR controls embryonic and adult myogenesis via mTORC1
Authors: Rion Nathalie , Castets Perrine , Lin Shuo , Enderle Leonie , Reinhard Judith R. , Eickhorst Christopher , Rüegg Markus A.
Published: March 2019

The formation of multi-nucleated muscle fibers from progenitors requires the fine-tuned and coordinated regulation of proliferation, differentiation and fusion, both during development and after injury in the adult. Although some of the key factors that are involved in the different steps are well known, how intracellular signals are coordinated and integrated is largely unknown. Here, we investigated the role of the cell-growth regulator mTOR by eliminating essential components of the mTOR complexes 1 (mTORC1) and 2 (mTORC2) in mouse muscle progenitors. We show that inactivation of mTORC1, but not mTORC2, in developing muscle causes perinatal death. In the adult, mTORC1 deficiency in muscle stem cells greatly impinges on injury-induced muscle regeneration. These phenotypes are because of defects in the proliferation and fusion capacity of the targeted muscle progenitors. However, mTORC1-deficient muscle progenitors partially retain their myogenic function. Hence, our results show that mTORC1 and not mTORC2 is an important regulator of embryonic and adult myogenesis, and they point to alternative pathways that partially compensate for the loss of mTORC1.

This article has an associated ‘The people behind the papers’ interview.
The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity
Authors: Elbediwy Ahmed , Zhang Yixiao , Cobbaut Mathias , Riou Philippe , Tan Ray S. , Roberts Selene K. , Tynan Chris , George Roger , Kjaer Svend , Martin-Fernandez Marisa L. , Thompson Barry J. , McDonald Neil Q. , Parker Peter J.
Published: March 2019

The elaboration of polarity is central to organismal development and to the maintenance of functional epithelia. Among the controls determining polarity are the PAR proteins, PAR6, aPKCι and PAR3, regulating both known and unknown effectors. Here, we identify FARP2 as a ‘RIPR’ motif-dependent partner and substrate of aPKCι that is required for efficient polarisation and junction formation. Binding is conferred by a FERM/FA domain–kinase domain interaction and detachment promoted by aPKCι-dependent phosphorylation. FARP2 is shown to promote GTP loading of Cdc42, which is consistent with it being involved in upstream regulation of the polarising PAR6–aPKCι complex. However, we show that aPKCι acts to promote the localised activity of FARP2 through phosphorylation. We conclude that this aPKCι−FARP2 complex formation acts as a positive feedback control to drive polarisation through aPKCι and other Cdc42 effectors.

This article has an associated First Person interview with the first author of the paper.
Troponin-I mediates the localization of selected apico-basal cell polarity signaling proteins
Authors: Casas-Tintó Sergio , Ferrús Alberto
Published: March 2019

Beyond its role in muscle contraction, Drosophila Troponin I (TnI; also known as Wings up A) is expressed in epithelial cells where it controls proliferation. TnI traffics between nucleus and cytoplasm through a sumoylation-dependent mechanism. We address here the role of TnI in the cytoplasm. TnI accumulates apically in epidermal cells and neuroblasts. TnI co-immunoprecipitates with Bazooka (also known as Par3) and Discs large (Dlg1, hereafter Dlg), two apico-basal polarity components. TnI depletion causes Baz and Dlg mislocalization; by contrast, the basolateral localization of Scribbled is not altered. In neuroblasts, TnI contributes to the polar localization of Miranda, while non-polar Dlg localization is not affected. Vertebrate phosphoinositide 3-kinase (PI3K) contributes to the apico-basal polarity of epithelia, but we find that Drosophila PI3K depletion alters neither the apical localization of TnI or Bazooka, nor the basal localization of Dlg. Nevertheless, overexpressing PI3K prevents the defects seen upon TnI depletion. TnI loss-of-function disrupts cytoskeletal β-Catenin, E-Cadherin and γ-Tubulin, and causes an increase in DNA damage, as revealed by analyzing γH2Av. We have previously shown that TnI depletion leads to apoptosis that can be suppressed by upregulating Sparc or downregulating Dronc. However, TnI-depleted cells expressing Sparc or downregulating Dronc, as well as those expressing p35 (also known as Cdk5α), that do not undergo apoptosis, still show DNA damage. This indicates that DNA damage is mechanistically independent of apoptosis induction. Thus, TnI binds certain apico-basal polarity signaling proteins in a cell type-dependent context, and this unveils a previously unsuspected diversity of mechanisms to allocate cell polarity factors.
Applying the convoy model to support in care situations
Authors: Antonucci Toni C. , Sherman Carey Wexler
Published: March 2019

This article considers the future of informal care situations, with a special focus on how social networks can support caring. Noting demographic changes and the endemic need for informal support, we outline the convoy model of social relations for proactive planning and contemporaneous caring. The article is grounded in empirical evidence, including comparative findings from four countries and about caring among two uniquely vulnerable populations: late-life remarried couples and lesbian and gay adults. Finally, we propose that caring be considered no longer an individual responsibility, but rather a family, community and societal responsibility basic to shared values and societal cohesion.
WhichBorders?
Authors: Maring Luke
Published: March 2019

The best arguments for a nation-state’s right to exclude unwanted outsiders actually condemn nation-level regimes of restriction. Two argumentative steps lead to this conclusion. The first points out that the best arguments for exclusion generalize: if they show that nation-states have the right to exclude, they perform the same service for a great many towns, cities, subnational states, and provinces. The second step constructs a dilemma. The right to exclude is important enough to justify the suffering of would-be immigrants, or it is not. If it is, the right to exclude is very important indeed–would-be immigrants often suffer grievously. But nation-level regimes would then be a serious moral problem: they would deprive a great many municipalities of a right that matters a great deal. Turning to the dilemma’s second horn, if the right to exclude is not important enough to justify the suffering of would-be immigrants, nation-level regimes are straightforwardly immoral. Either way, we arrive at this paper’s central thesis: the best arguments for a nation-states right to exclude actually condemn nation-level regimes of exclusion.
Crystal structure of 2-chloro-4-(prop-2-yn-1-yloxy)-6-(thiophen-2-yl)-1,3,5-triazine, C10H6ClN3OS
Authors: Zuo Zhenyu , Guo Tianyu , Song Xiaomei , Guo Dongyan , Song Xiao
Published: March 2019

C10H6ClN3OS, monoclinic, C2/c (no. 15), a = 18.3141(4) Å, b = 7.31845(15) Å, c = 17.7885(4) Å, β = 110.495(3)°, V = 2233.30(9) Å3, Z = 8, T = 150(2), R
gt(F) = 0.0331, wR
ref(F2) = 0.0904.
Crystal structure of (dibenzyl sulphoxide-κO)bis(2-chlorobenzyl-κC
1)dichloridotin(IV), C28H26Cl4OSSn
Authors: Lee See Mun , Lo Kong Mun , Tiekink Edward R.T.
Published: March 2019

C28H26Cl4OSSn, monoclinic, P21/c (no. 14), a = 10.6342(2) Å, b = 12.9298(3) Å, c = 20.3576(4) Å, β = 101.820(1)°, V = 2739.78(10) Å3, Z = 4, R
gt(F) = 0.0197, wR
ref(F
2) = 0.0520, T = 100(2) K.
Imagining and tinkering with assistive robotics in care for the disabled
Authors: Mossfeldt Nickelsen Niels Christian
Published: March 2019

The media and political-managerial levels focus on the opportunities to re-perform the Scandinavian welfare states through digitization. Especially in Denmark, this trend is prominent. Welfare technology is a Scandinavian notion used to point at assistive technologies intending to support the elderly, the disabled and care providers. Feeding assistive robotics (FAR) is a welfare technology relevant to citizens with no or low function in their arms. Despite national dissemination strategies, it proves difficult to recruit suitable users. There have been many promises for the potential of assistive robotics including more cost-efficient healthcare delivery, engaged patients and connected care providers. However, the realities of enacting assistive robotics, whether as patients or care providers, can be complicated in ways often unanticipated by government agencies and technology developers. This study discusses governmental agencies’ and technology developers’ visions with regard to what robotics may do and argues that these visions intertwine with affected stakeholders’ organizing of theirworlds. On this founding, the article discusses the resulting tinkering during implementation. The study exemplifies and demonstrates how ethnography can be used as an important method in Human Robot Interaction (HRI) research. The Actor Network Theory idea of ‘follow the actor’ inspired the study that took place as multi-sited ethnography at different locations in Denmark and Sweden. Based on desk research, observation of meals and interviews the study examines sociotechnical imaginaries and their practical and ethical implications.Human and FAR interaction demands engagement, sustained patience and understanding of the citizen’s particular body, identity and situation. The article contributes to the HRI literature by providing detailed empirical analysis based on an ethnographic studywhere political strategies, technology developers’ assumptions and affected stakeholders’ everyday hassles are in focus at the same time.
On the Role of Hydrogen Atom Transfer (HAT) in Thermal Activation of Methane by MnO+: Entropy vs. Energy
Authors: Sweeny Brendan C. , Pan Hanqing , Ard Shaun G. , Shuman Nicholas S. , Viggiano Albert A.
Published: March 2019

The temperature dependent kinetics and product branching fractions of first-row transition metal oxide cation MnO+ with CH4 and CD4 at temperatures between 200 and 600 K are measured using a selected-ion flow tube apparatus. Likely reaction mechanisms are determined by comparison of temperature dependent kinetics to statistical modeling along calculated reaction coordinates. The data is well-modeled with the reaction proceeding over a rate limiting four-centered transition state leading to an insertion intermediate, similar to reactions of NiO+ and FeO+, and showing characteristics of proton-coupled electron transfer (PCET). However, a more direct pathway traversing a transition state of hydrogen atom transfer (HAT) character to a hydroxyl intermediate is found to possibly be competitive, especially with increasing temperature. While uncertainties in calculated energetics limit quantitative assessment of the role of HAT at thermal energies, it is clear that this mechanism becomes increasingly prevalent in higher energy regimes.
The APOBEC3 genes and their role in cancer: insights from human papillomavirus
Authors: Smith Nicola J , Fenton Tim R
Published: March 2019

The interaction between human papillomaviruses (HPV) and the apolipoprotein-B mRNA-editing catalytic polypeptide-like (APOBEC)3 (A3) genes has garnered increasing attention in recent years, with considerable efforts focused on understanding their apparent roles in both viral editing and in HPV-driven carcinogenesis. Here, we review these developments and highlight several outstanding questions in the field. We consider whether editing of the virus and mutagenesis of the host are linked or whether both are essentially separate events, coincidentally mediated by a common or distinct A3 enzymes. We discuss the viral mechanisms and cellular signalling pathways implicated in A3 induction in virally infected cells and examine which of the A3 enzymes might play the major role in HPV-associated carcinogenesis and in the development of therapeutic resistance. We consider the parallels between A3 induction in HPV-infected cells and what might be causing aberrant A3 activity in HPV-independent cancers such as those arising in the bladder, lung and breast. Finally, we discuss the implications of ongoing A3 activity in tumours under treatment and the therapeutic opportunities that this may present.
Nicaragua y una ventana al mundo La revista Ventana (1960-1963)
Authors: Moro Diana
Published: March 2019

En la década de 1960, en Nicaragua, la revista Ventana, dirigida por los jóvenes universitarios, Sergio Ramírez y Fernando Gordillo, se constituyó en una caja de resonancia política y literaria. Confluyeron en ella el debate político y el reclamo de libertad y de autonomía, en el contexto de la dictadura con una apuesta literaria amplia y cosmopolita. Se dieron cita allí una multiplicidad de autores y textos literarios procedentes de diversas lenguas y culturas.
Poesía de mujeres mayas
Authors: Fuentes Belgrave Laura
Published: March 2019

Consuelo Meza y Aída Toledo son dos reconocidas investigadoras y especialistas en la literatura escrita por mujeres, quienes, en su obra publicada en México, La escritura de poetas mayas contemporáneas producida desde excéntricos espacios identitarios (Universidad Autónoma de Aguascalientes, 2015), han apostado por visibilizar la poesía de las mujeres mayas de Guatemala. Esta obra contribuye al diálogo intercultural, así como a la encarnación -más allá del papel-, de los discursos sobre descolonización, empoderamiento e igualdad de género, tan invocados en la actualidad y tan poco materializados en la práctica. Si bien, en el libro se realiza un estado de la cuestión de 29 autoras y un análisis de la obra de 12 de ellas, en este espacio solamente se reproduce una pequeña selección que incluye a algunas de las primeras escritoras mayas, cuya poesía todavía vibra en las letras centroamericanas, pues como afirma en su capítulo primero el Popol Vuh: “Ta xpe k´ut u tzij waral”, es decir, “llegó aquí entonces la palabra…”
Regímenes de corporalidad y recientes transmigraciones africanas en Costa Rica: Dispositivos y discursos sociales
Authors: Acuña González Guillermo E.
Published: March 2019

Entre los años 2015 y 2016 se produjo un aumento en las movilidades extraregionales a través de Centroamérica. La presencia de migrantes provenientes de varios países de África, produjo desafíos institucionales para su abordaje, así como la elaboración de discursos sociales estructurados en categorías raciales. Un concepto fundamental para entender dicha coyuntura es el cuerpo migrante, en su implicación ontológica y su carácter de trashumancia sobre las narrativas del poder representado por los Estados-nación y vinculado con el funcionamiento de regímenes corporales, histórica y socialmente situados. Esta reflexión recupera la construcción racializada del cuerpo migrante en los dispositivos institucionales y en los discursos sociales vinculados con la coyuntura de las transmigraciones africanas producidas en Costa Rica en los últimos años.
Language and Cultural Awareness of a Non-Native ESP Teacher
Authors: Forteza Fernandez Rafael F. , Batista Gonzalez Maria del C.
Published: March 2019

Introduction. The relation between culture and language is a central issue in foreign language teaching and research where the need to give cultural content the same value as language content and language skills has been stressed. However, conceptualization of teacher language awareness, by focusing largely on formal aspects of language, largely neglects culture as a component of teacher cognition. This paper expands the category of ESP-teacher language awareness suggesting the inclusion of cultural awareness as a separate component of teacher cognition. This concept extension actualizes ESP teaching in the situation shaped by unprecedented mobility and intercultural contacts.
Materials and Methods. The historic-logical method was used to determine shortcomings of pedagogical experience and the need to teach culture in ESP. Grounded theory, as an inductive methodology, was utilized to generate conceptual expansion theoretically tied with research in medical and business communication as well as with data on population movement and international s cientific cooperation.
Results. We defined ESP-cultural knowledge as a system comprising the permanent (know-that) and temporary (know-of) cultural manifestations in a society as well as how they are manifested through language (know-how). That system practical representation is exemplified in medicine and business English discourse. The study expands the structure of ESP-TLA, claiming the focus on cultural awareness as part of ESP discourse which fosters cultural-response education.
Discussion and Conclusion. Such claim is pertinent to practitioners involved in the tourism industry, health care, economics, and academic activities such as research and development. This paper is relevant for teachers of English for Specific purposes in the fields mention ed above as well as for researchers engaged in analyzing the problems and methods of teaching a foreign language. However, because of the multiple manifestations and complexity of student motivation to get ESP course, the paper acknowledges the difficulties in addressing cultural content salient to all student s in class, an aspect meriting further research.
La educación y el Derecho en torno a un nuevo paradigma transformador
Authors: Bayuelo Schoonewolff Porfirio Andres
Published: March 2019

ResumenDesde hace mucho tiempo la educación en Latinoamerica se encuentra en crisis, por ello las instituciones de educación superior, entidades del Estado y organismos internacionales han tomado la responsabilidad de establecer una cultura de educar en y para lo superior en términos de calidad, lo cual ha permitido que se lleven a cabo programas, proyectos, convenciones y demás que contribuyan al mejoramiento de la educación. Igualmente, en las facultades de Derecho, tambien se observa latente esta situación, evidenciandose, en su gran mayoria, en los profesionales que al salir de la academia se encuentran con un mundo diferente al aprendido. Es por esto que se han determinado los principales inconvenientes y se plantea un nuevo paradigma para la enseñanza narrativa del Derecho. Con esta organización se complementara la ensefianza del Derecho narrativo y complejo que contara con altos estandares de calidad en la educación, siendo transformador social y contribuyente al progreso social, económico, politico y tecnológico de Colombia y Latinoamerica. AbstractFor a long time, education in Latin America has been in crisis; for this reason, institutions of higher education, state entities and international bodies have taken on the responsibility to establish a training plan to teach both in higher education and for higher education, in terms of quality. This fact has allowed the development of programs, projects, conventions and other activities which contribute to improvement of education. Likewise, at Law faculties, this underlying situation is also observed, having clear evidence of it when professionals graduate from the university to face a different context from the one learnt. Therefore, the main inconveniences have been determined and a new paradigm for teaching Legal Narrative is suggested. With this structure, teaching Legal complex narrative will be complemented, having high quality standards in education and being a social reformer, as well as contributing to social, economic, political and technological progress in Colombia and Latin America.
El Ágora Griega. ¿Una oportunidad digital? Acercamiento al estado del arte en Colombia
Authors: Hern Oona Isabel , Torres Oviedo Jairo Miguel
Published: March 2019

ResumenLa influencia y auge de los recursos tecnológicos en el desarrollo de las sociedades actuales, en particular del Internet al ser el fenómeno lider en la revolución de la Tecnologia, Información y Comunicación, ha gestado una nueva manera de interacción entre los seres humanos al ser sefialada como instantánea, actual y universal, en la medida en que permite el acercamiento de las personas sin limites o barreras geograficas; de ahi que se empiece a considerar y avalar este recurso tecnológico como medio y espacio ideal para superar las deficiencias de la democracia participativa, e incluso construcción de una deliberativa. El presente documento es resultado de los avances en la construcción del estado del arte de la investigación Democracia y Libertad de expresión en Internet. Análisis de la democracia digital en Colombia, y en él se presentan las posiciones que se construyen alrededor de la democracia digital y los acercamientos teóricos en nuestro pais. No obstante, la reflexión se fundamenta a partir de la comprensión que hacemos respecto de la participación ciudadana en las sociedades democraticas, donde el ejercicio de la libertad de expresión, la vinculación y empoderamiento ciudadano es producto de una educación civica al ser entendida la ciudadania como practica reflexionada, consciente e informada a traves de la cual se permite lograr la reivindicación y protección de derechos fundamentales dentro de un marco plural y deliberativo.AbstractThe influence and technological resources boom in the development of modern societies, particularly the Internet phenomenon to be the leader in the revolution of Technology, Information and Communication, has managed a new way of interaction between human beings to be marked such as instant, current and universal, as it allows the approach of people without boundaries or geographical barriers; hence begin to consider and endorse this technology as a perfect medium to overcome the shortcomings of participatory democracy space, and even building a deliberative. This document is the result of progress in building state of the art of democracy and freedom of expression Internet research. Analysis of digital democracy in Colombia, and he positions that are built around the digital democracy and theoretical approaches in our country are presented. However, reflection is based from the understanding that we respect citizen participation in democratic societies, where the exercise of freedom of expression, citizen involvement and empowerment is the product of a civic education to be understood citizenship as thoughtful, conscious and informed by practice which achieves claim and protection of fundamental rights within a plural and deliberative framework.
Patlıcan Tohumlarında Bitki Büyüme Düzenleyici Rizobakteri Uygulamalarının Kurşuni Küf (Botrytis cinerea Pers.: Fr.) Hastalığına Etkileri
Authors: ALTINOK Hacer Handan , ÇİFÇİ Gülperi
Published: March 2019

Ülkemizde
örtü altı patlıcan (Solanum melongena
L.) üretiminde kurşuni küf hastalığı (Botrytis
cinerea Pers.) önemli verim kayıplarına neden olmaktadır. Bu çalışmada,
kurşuni küf hastalığına karşı bazı
bitki gelişme düzenleyici rhizobakterilerin
etkinlikleri araştırılmıştır. Bacillus
spp. (B379c, B10a ve 76A-1) ve Pseudomonas
spp. (P07-1, P07-4 ve 85A-2)
izolatları in vitro koşullarda B. cinerea’nın (Bc-TR07) miseliyal gelişimini %21-33 oranında
engellemiştir. PGPR izolatları arasında P. aeruginosa (P07-1), saksı denemelerinde sadece patojen inokulumu
içeren pozitif kontrole göre %58.1 etki oranı ile en başarılı izolat olarak
belirlenmiştir. Bu
izolat bazı bitki gelişim parametrelerini de benzer şekilde önemli oranda
arttırmıştır. P07-1 izolatı, patojen inokulasyonundan 72 saat
sonra patlıcan bitkilerinde toplam prolin içeriğini pozitif kontrole göre %27.0
oranında artırırken, aynı sürede savunma enzimlerinden katalaz (CAT) ve
peroksidazı (POX) sırasıyla %22.8 ve %27.7 oranında artırmıştır. Bu izolatı CAT ve POX enzim aktiviteleri
açısından sırasıyla P. putida (P11-4)
ve B. amyloliquefaciens (76A-1) takip etmiştir. Test
edilen PGPR izolatlarının başlıca hastalık baskılama mekanizmalarının, bitki
büyüme düzenleyici ve dayanıklılığı uyarıcı özellikleri olduğu belirlenmiştir
Çiftçilerin Tarım Sigortası Yaptırma İstekliliği: Konya İli Ilgın İlçesi Örneği
Authors: İKİKAT TÜMER Emine , AĞIR Hasan Burak , USLU Zehra
Published: March 2019

Tarım sektörü; doğal, sosyal ve ekonomik risk ve
belirsizliklerden en çok etkilenen sektördür. Bu risk ve belirsizlikleri en aza
indirmenin en kolay yollarından birisi de tarım sigortalarıdır. Tarım
sigortaları çiftçinin kayıplarını tazmin etmenin yanı sıra işletmelerin
varlığını sürdürmesini de sağlamaktadır. Araştırmada çiftçilerin bitkisel ürün
sigortası yaptırmalarında etkili olan faktörlerin belirlenmesi amaçlanmıştır.
Araştırma Konya ili Ilgın ilçesinde yürütülmüştür. Araştırmanın materyalini 95
üretici ile yüz yüze yapılan anketlerden elde edilen veriler oluşturmaktadır.
Elde edilen verilerin değerlendirilmesinde tanımlayıcı istatistikler ve Binomial
probit modeli kullanılmıştır. Analiz sonucunda
çiftçilerin bitkisel üretim tecrübesi, ailedeki birey sayısı, çiftçinin
eğitimi, bitkisel üretim geliri ve bitkisel ürün sigortaları kapsamının
genişletilmesi isteği ile pozitif yönlü, işletme dışı yatırımla ise negatif
yönlü ilişki olduğu tespit edilmiştir.
"Qué hacer"
Authors: Herazo Girón Fernando Antonio
Published: March 2019

Este ensayo tiene como objetivo fundamental analizar el papel del docente universitario para contribuir a la calidad y excelencia de la institución universitaria en la cual se desarrolla nuestra labor educativa, describiendo dentro de la metodología deductiva e inductiva las formas más eficaces para llevar a cabo, de la manera más amplia y productiva, el enfoque pedagógico de la investigación acciónparticipación en la interacción recíproca del docente-discente, dentro de los fines de la investigación de aula, con el enfoque -en el proceso de enseñanza aprendizaje- de conseguir que el estudiante se convierta en el artífice de su propio aprendizaje teniendo al docente como un orientador y mentor de ese proceso, para lo cual habremos de señalar -dentro de ese proyecto pedagógico- cuáles podrían ser las metodologías dinámicas más adecuadas para internalizar el conocimiento y la investigación en los discentes, así como el logro de conseguir una universidad que pueda convertirse, a través de su elemento "QUÉ HACER" Fernando Antonio Herazo Girón 1 humano y tecnológico, en el artífice del desarrollo de su región de influencia. En este enfoque es indispensable poner atención a las Tics (Tecnologías de la Información y la Comunicación) en los cambios de actitudes y aptitudes del discente-docente y del docentediscente. Las Tics surgen como trasformación de la pedagogía desde la década de los sesenta demostrando la importancia de los medios tecnológicos en la educación (Garcés-Prett, Ruiz-Cantillo, & Martínez Ávila, 2014).
De donald trump y otros milagros del progresismo
Authors: Pacheco Ceballos Daniel , Vivas Gómez Ricardo
Published: March 2019

El 201 6 pasará a la historia de la humanidad como el año en el cual se institucionalizó una tendencia ideológica mundial que pidió a gritos el freno del caos mundial y del excesivo libertinaje con el que se quiso encausar el inicio de este milenio. Salta a la vista lo evidente de tal aseveración si se tiene como referente lo acaecido con los procesos democráticos gestados en países como Colombia, Reino Unido y Estados Unidos, y como por si eso fuera poco, desde ya se avizora gran expectativa con lo que serán las contiendas a desplegar por Marine Le Pen y Frauke Petry en Francia y Alemania respectivamente.
Virtud de la justicia en david hume
Authors: Rey Encinales Laura Sofía
Published: March 2019

En el presente texto se abordan las ideas fundamentales sobre la justicia expuestas por David Hume en la sección tres y apéndice tres de su libro "investigaciones sobre los principios de la moral" y en el Tomo 111. Parte 11. Sección I y 2. En los presentes apartados el autor David Hume pretende mostrar una visión de la justicia como una virtud que nace de la necesidad ante los escasos medios que proporciona la naturaleza, la generosidad limitada de los hombres y el egoísmo. Sólo en estos casos es donde seria imaginable y útil la virtud de la justicia. Además da a conocer su postura con respecto a si dicha virtud se fundamenta en la razón o es producto del artificio y convenciones humanas, de ahí que responde a la pregunta: ¿Es la justicia una virtud natural o artificial?, para Hume es una virtud artificial que es producida por impresiones.
Endomarketing
Authors: Arbelaez Diego Cardona , Escudero Castillo Enis Margarita , Machado Licona Jhorquis
Published: March 2019

El endomarketing es tomado como una herramienta que permite la generación de identidad de las organizaciones, ya que constituye un programa, cuyo objetivo es determinar las características, capacidades, necesidades y deseos de los clientes internos (serna, 2009), con lo cual se busca establecer estrategias que aumente su nivel de motivación y a su vez de compromisos de los mismos para con las organizaciones (ferrell y hartline 2012), Finalmente todo ello redunda en beneficios para la organizaciones, traducidos en calidad en todos los niveles y mejoramiento de la imagen.
Acto administrativo y nuevas tecnologías
Authors: Bautista	Fernández Miguel Arturo , Montoya Villamizar Juan Diego
Published: March 2019

La sociedad de la información y del conocimiento ha generado cambios en todos los niveles de relacionamiento. Hoy día las personas, empresa y gobierno tienen la posibilidad de generar comunicación a través de medios electrónicos. Sin embargo, el gobierno está sometido al principio de legalidad –aún más que las personas y empresas- en la forma de comunicarse, estableciendo procedimientos detallados que aseguren que todas las decisiones que desde allí se tomen estén ajustadas a la constitución, la ley y el principio democrático. Por esto, se procedió a revisar cuales son los insumos que desde las nuevas tecnologías se le han otorgado al Estado y al acto administrativo, forma principal por la cual crea, modifica o extingue situaciones jurídicas de interés de la sociedad. Las principales fuentes de revisión fueron la ley, jurisprudencia y doctrina, articulados bajo una investigación sistemática.
Fuentes de financiamiento para las mypimes Comerciales familiares de bucaramanga 2006-2010
Authors: Di	Marco	Morales Raúl Omar
Published: March 2019

Cuando se trata de fuente de financiamiento para el crecimiento de la empresa y el aumento de las utilidades en las Mipymes familiares, es común que el emprendedor se apoye sólo en sus ahorros personales o en los de la familia e inclusive en los de los amigos; si fuesen insuficientes e inadecuados, accedería a un canal más formal, como son los de la Banca Financiera. Algunas fuentes de financiamiento sólo son usadas para las operaciones diarias o para la expansión de una empresa, por lo que también se opta por participar en algún programa gubernamental que brindan financiamiento a mipymes; el Gobierno Nacional busca favorecer el acceso a recursos de crédito mediante el esquema de garantías de riesgo compartido, apoyando y desarrollando mecanismos alternativos de financiación a través de las fiduciarias públicas y mediante acuerdos de cooperación con terceros. Esta investigación se viene desarrollando alrededor de la aplicación y los efectos del crédito bancario como fuente principal de financiamiento en las empresas familiares en el sector comercial de Bucaramanga en el segundo período presidencial del Dr. Alvaro Uribe Velez (2006-2010), analizando el efecto del crédito en el crecimiento de la empresa, debido a que en la actualidad no se cuenta con un estudio de este tipo. Se llegó a establecer que el 80% de los empresarios seleccionados manifestaron tener un crecimiento de su empresa a partir de un proyecto de expansión, donde la forma de financiamiento más utilizada fue la del crédito bancario; además, se encontró que su mayor preferencia obedece a proyectos asociados a establecer nuevos puntos de ventas y al aumento del área comercial. Se concluyó que entre más costoso sea el proyecto a desarrollar, más factibilidad existirá para acceder a créditos bancarios antes que utilizar recursos propios.
Falencias en el recaudo del impuesto de industria y comercio en oiba santander
Authors: Zafra Reyes Cristhian Eduardo , Díaz Murcia Pablo Andr´es , Alcides Avellaneda Campo
Published: March 2019

Este artículo presenta elementos significativos relacionados con el impuesto de industria y comercio en el municipio de Oiba Santander, identifica algunas de sus falencias. Se hace necesario estudiar los aspectos que inciden en el recaudo del Impuesto para medir la cultura tributaria que tiene el contribuyente, principalmente en los últimos mandatos de dos administraciones consecuentes, ya que no se conocen estudios relacionados con este tema, que puede llegar al beneficio de una comunidad junto del ente territorial por medio de la planeación y optimización de un impuesto.