bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in newly notified cases and control of tuberculosis in China: time-series analysis of surveillance data
Authors: Wang Yesheng , Zhu Wenlong , Li Tao , Chen Wei , Wang Wei-bing
Published: November 2020

Background: China has made progress in tuberculosis control, but this disease remains a burden in many regions of China. We performed time-series analysis to examine changes in the rates of newly notified and newly smear-positive cases of tuberculosis in different regions of China from 1997 to 2018 and assessed the effect of the current control program. Methods: National and provincial notification data on tuberculosis from 1997 to 2018, which covers 31 provinces in mainland China, were extracted from the Chinese public health science data center. The annual percentage changes in newly notified and smear-positive cases were analyzed using a joinpoint regression method. Results: There were 18,646,672 newly notified tuberculosis cases from 1997 to 2018, with the greatest number in 2005. A total of 6,605,414 of these cases (35.42%) were smear-positive cases. Most provinces had significant declines in newly notified and smear-positive cases during the most recent years. The declines in newly notified cases were faster in the eastern and central provinces than in the western provinces. Conclusions: The burden of tuberculosis has been declining throughout China during recent years, but tuberculosis in western China continues to be a public health emergency that needs to be urgently addressed. Effective prevention and control strategies are needed for regions with high disease burdens and those with increasing or unchanging numbers of newly notified and smear-positive cases of tuberculosis.
Effects of bone marrow mesenchymal stem cell-derived exosomes on bone formation on titanium
Authors: Zhang Xiaoling , Du Liangzhi , Zhao Ningbo , Zhu Lizhe , Wang Lei , Chang Xiaofeng
Published: November 2020

Background: In recent years, researchers have found that exosomes, an important component of intercellular signal transduction and exchange, have great significance in bone tissue repair. In this study, to further promote the development of oral implants, preliminary in vitro experiments were conducted to verify the different concentrations of exosomes from bone marrow mesenchymal stem cells (BMSC-exos) for osteogenesis on the surfaces of titanium sheets.Methods: In this experiment, rabbit bone marrow mesenchymal stem cells(BMSCs) were seeded on the surfaces of 10 mm × 10 mm × 1 mm square titanium sheets and were divided into four groups to investigate their adsorption, proliferation and osteogenesis after treatment with different concentrations of BMSC-exos: 1. BMSCs + titanium + 0 µg/ml BMSC-exos; 2. BMSCs + titanium + 10 µg/ml BMSC-exos; 3. BMSCs + titanium + 25 µg/ml BMSC-exos; and 4. BMSCs + titanium + 50 µg/ml BMSC-exos.Results: Compared with the control group, BMSCs’ adsorption, extension, proliferation and osteogenesis on titanium sheets were significantly increased in the Exosomes group.Conclusions: Exosomes can promote the bone formation of BMSCs on titanium plates by promoting adsorption, extension, proliferation, production of alkaline phosphatase(ALP) and type I collagen and mineralization during the osteogenesis process.
Lateral Variations of Electrical Conductivity in the Lower Mantle Constrained by Swarm and CryoSat-2 Missions
Authors: Velímský Jakub , Knopp Ondřej
Published: November 2020

The electrical conductivity is an important geophysical parameter connected to the thermal, chemical, and mineralogical state of the Earth's mantle. In this paper we apply the previously developed methodology of forward and inverse EM induction modelling to the latest version of satellite-derived spherical harmonic coefficients of external and internal magnetic field, and obtain the first 3-D mantle conductivity models with contributions from Swarm and CryoSat-2 satellite data. We recover degree 3 conductivity structures which partially overlap with the shape of the large low-shear velocity provinces in the lower mantle.
Povezanost veličine osobnog prostora, spola i stupnja anksioznosti kao osobine ličnosti
Authors:   Odjel za neuropsihijatriju, KB ", Aziraj Smajić Vildana ,   Dr. Irfan Ljubijankić",   , Bihać, BIH, Nakić Radoš Sandra ,   Odjel za psihologiju, Hrvatsko katoličko sveučilište, Zagreb
Published: November 2020

Osobni prostor se definira kao područje koje pojedinac održava oko sebe i u koji drugi ne mogu ući, a da ne izazovu nelagodu. Cilj istraživanja je bio ispitati veličinu osobnog prostora s obzirom na spol sudionika i nepoznate osobe koja ulazi u osobni prostor te ispitati povezanost veličine osobnog prostora i stupnja anksioznosti kao osobine ličnosti. Veličina osobnog prostora izmjerena je pomoću tehnike zaustavljanja u kojoj se svakom sudioniku/-ici (N = 145) približavala nepoznata osoba muškog i ženskog spola iz četiri različita smjera (sprijeda, straga, slijeva i zdesna), a zadatak sudionika je bio da kaže “stop” u trenutku kad osjeti nelagodu zbog njene blizine. Anksioznost kao osobina ličnosti izmjerena je pomoću Upitnika anksioznosti kao stanja i osobine ličnosti (STAI). Rezultati su pokazali da se prosječna udaljenost između sudionika i nepoznate osobe kreće između 70 i 80 cm i za sudionice i za sudionike. Utvrđeno je da se žene i muškarci ne razlikuju značajno u veličini osobnog prostora, te da nema značajnih razlika niti s obzirom na spol osobe s kojom su u interakciji. S obzirom na to da je utvrđena značajna pozitivna povezanost između stupnja anksioznosti kao osobine ličnosti i veličine osobnog prostora, zaključci su sukladni očekivanjima te rezultatima dosadašnjih istraživanja. Ključne riječi: osobni prostor, anksioznost, tehnika zaustavljanja
Hrvatski prijevod Upitnika kognitivne emocionalne regulacije – skraćeni oblik
Authors:   Klinika za dječje bolesti, Klinički bolnički centar Split, Split, Mišetić Irena , Bubić Andreja ,   Filozofski fakultet, Sveučilište u Splitu, Split
Published: November 2020

Cilj ovog istraživanja bio je razvoj hrvatskog oblika Upitnika kognitivne emocionalne regulacije – skraćeni oblik i provjera nekih njegovih psihometrijskih obilježja na uzorku 206 polaznika psihoterapije ili psihološkog savjetovanja. Rezultati konfirmatorne faktorske analize podržavaju predloženi 9-faktorski model ovog upitnika. Ovim instrumentom omogućeno je mjerenje širokog raspona kognitivnih strategija emocionalne regulacije jednim upitnikom. Mjerenje tih strategija pritom može otkriti ranjivosti ili snage pojedinca u nošenju s negativnim životnim događajima te se može korisno upotrijebiti u planiranju psihoterapijskih intervencija (osobito u području kognitivno-bihevioralnih terapija). Ključne riječi: kognitivna emocionalna regulacija, kognitivno suočavanje, Upitnik kognitivne emocionalne regulacije – skraćeni oblik
Razvojni profili djece s poremećajem iz spektra autizma
Authors:   Poliklinika za rehabilitaciju slušanja i govora SUVAG, Zagreb, Šimir Ana , Šimleša Sanja ,   Edukacijsko-rehabilitacijski fakultet, Sveučilište u Zagrebu, Zagreb, Cepanec Maja ,   Edukacijsko-rehabilitacijski fakultet, Sveučilište u Zagrebu, Zagreb
Published: November 2020

Istraživanja pokazuju kako su neujednačeni razvojni profili, s boljim neverbalnim u odnosu na verbalne sposobnosti, karakteristika djece s poremećajem iz spektra autizma (PSA). Cilj ovog istraživanja bio je prikaz razvojnih profila djece sa PSA-om na Razvojnom testu Čuturić (RTČ-P), opis njihovih specifičnosti s obzirom na sveukupne intelektualne sposobnosti te razlika između različitih razvojnih područja. Uzorak je činilo 25 djece kod koje je utvrđen PSA. Razvojni profili su oblikovani obzirom na postignuća na zadacima RTČ-P-a. U skladu s očekivanjem, djeca sa PSA-om pokazala su neujednačene razvojne profile. Neujednačenost razvojnih područja je uočena i kod djece s prosječnim (n = 6) i kod djece s ispodprosječnim intelektualnim sposobnostima (n = 19). U skladu s pretpostavkom i stranim istraživanjima, prosječna postignuća na neverbalnim sposobnostima pokazala su se boljima od onih na verbalnim sposobnostima. Pritom se kao područje s najboljim rezultatima ističu vizuoperceptivne sposobnosti. Ako sagledamo verbalne sposobnosti, pokazalo se kako je jezična proizvodnja nešto bolja u odnosu na razumijevanje, što je u skladu s pretpostavkom o smjeru neujednačenosti jezičnih sposobnosti. Zaključno, razvojni profili dobar su način isticanja djetetovih jakih i slabih strana, što je važno kod oblikovanja intervencije. Oni također mogu biti korisni u diferencijalnoj dijagnostici PSA-a i drugih razvojnih teškoća. Ključne riječi: poremećaj iz spektra autizma, razvojni profili, Razvojni test Čuturić
SOCIAL CRITICISM TOWARDS LATE VICTORIAN SOCIETY AND THE THEME OF SACRIFICE IN OSCAR WILDES THE HAPPY PRINCE
Authors:   Van Lang University, Vietnam., Thanh Nha , M.A Chau , Thi Hoa , M.A Hoang ,   Van Lang University, Vietnam.
Published: November 2020

The social context in the period of Victorian era is a valuable point to study. Those who belonged to the upper class lived wealthily and irresponsibly. One reverse side was that although they were in the high social status, they seemed to be poor in knowledge and tried to act as if they had had profound understanding of everything. In addition, the statue of the Happy Prince was considered a punishment for the leader who had been irresponsible for the life of his local citizens during his lifetime. When he died, he had to witness everything and endured what the local citizens had experienced such as the utter misery and the harshness of the weather. This research is aimed at giving critiques on the social context of the late Victorian era and analyzing deeply the theme of sacrifice through Oscar Wildes The Happy Prince. The Victorian era was known as the era of materialism and individualism in which the luxurious life of the rich was depicted clearly and self-importance was on top of everything and that resulted in the ignorance of the poors lives.
PENAL MEDIATION AS AN ALTERNATIVE RESOLUTION IN THE INDONESIAN CRIMINAL JUSTICE SYSTEM (A DIGNIFIED JUSTICE JURISPRUDENCE)
Authors:   Lecturer in Law for Postgraduate (MIH) at the Faculty of Law, Universitas Dr. Soetomo Surabaya, East Java-Indonesia., Ucuk Suyono , SH. , MHum Yoyok
Published: November 2020

Restorative justice perspective in this paper sees a penal mediation as a non-penal means within the Law. This institution has been utilised as an alternative in the Indonesian Criminal Justice System to deliver dignified justice in criminal cases. Although this model appeared as vague, since stipulated only between the lines in the Indonesia Criminal Code (KUHP) and the Criminal Procedure Code (KUHAP), the concept of restorativejustice has been existing in the Indonesian Volksgeist (the Spirit of the Indonesian, i.e. Pancasila) from the begining of time. This author would argue bellow that penal mediation has been used to mitigate penal cases by law enforcement institutions in order to achieve dignified justice in the concept of restorative justice, to serve human as human beings recognised by the Law in the Pancasila Legal System. The police may use penal mediation basing upon their discretionary power and the public prosecutors may also use their own prerogative power or the what so called prosecutors power of opportunity in place of the due process and make creative innovations, beginign from misdemeanor or complaint offenses. Even Indonesian judges have broad discretionary authority to use penal mediation in solving criminal cases so that the dignified justice, can be obtained, particularly by victims de lege lata.
LEARNING TAFSEER OF AL-QURAN DURING COVID-19 PANDEMIC: STUDENTS SATISFACTION TOWARDS LECTURERS INTERACTION
Authors:   Senior Lecturer, Faculty of Quranic and Sunnah Studies, UniversitiSains Islam Malaysia, Nilai, Negeri Sembilan, Malaysia., Akhiruddin Ibrahim Mohamed
Published: November 2020

The implementation of Movement Control Order (MCO) in Malaysia during COVID-19 pandemic that disallowed usual face-to-face lectures has affected both public and private higher education institutions. The best alternative to ensure that learning sessions are continuously uninterrupted is by online learning which is the implementation of teaching and learning sessions through technology systems. Lecturers interaction in online learning method is very important in providing understanding to students. Therefore, the aim of this study is to know the students satisfaction towards lecturers interaction in online learning of Tafsir al-Quran course. Method used in this research is quantitative design whereas a semi-structured questionnaire distributed among 2ndyear students of Quran and Multimedia Studies Program, Faculty of Quran and Sunnah Studies, UniversitiSains Islam Malaysia. This questionnaire has to be answered via Microsoft Forms and the data obtained then were analyzed descriptively through computer software namely Microsoft Excel and Statistical Package for Social Sciences (SPSS) version 25. The results of the study found that the level of students satisfaction towards lecturers interaction in online learning of Tafsir al-Quran course were at a high level. In this regard, the interaction of lecturers is very important in providing understanding among students, as well as systematic and easy-to-understand of teaching methods.
FISH PRE-TREATED WITH SALT BRINE: PROCESS STUDY AND DRYING KINETICS
Authors:   Cheikh Anta Diop University, Postal Code:5005, Dakar, Senegal., Lamine Coly Mamadou ,   Centre For Study and Research on Renewable Energies, Dakar, Senegal., Seck Gueye Mamadou ,   Cheikh Anta Diop University, Postal Code:5005, Dakar, Senegal., Mbaye Boucounta ,   Cheikh Anta Diop University, Postal Code:5005, Dakar, Senegal.,   Centre For Study and Research on Renewable Energies, Dakar, Senegal., Faye Waly ,   Cheikh Anta Diop University, Postal Code:5005, Dakar, Senegal., Diamanka Aicha ,   Cheikh Anta Diop University, Postal Code:5005, Dakar, Senegal.
Published: November 2020

This work is part of a study for the conservation of fish products through solar drying. The grey seabream is dried after a pre-treatment of 16 hours in a salt brine under two conditions: on a rack in open air and in a solar dryer. The tests were carried out under average irradiance conditions of 592.76 W/m², an average ambient temperature of 30°C and an average air temperature in the dryer of 50°C. The results obtained, allowed us to reach a final humidity of 32% from an initial humidity of 65% in a wet basis. The drying was processed in 15 hours, (i.e. two days in the dryer) and 24 hours (i.e. three days in the open air). The modeling of the drying kinetics of the grey sea bream is carried out from empirical or semi-empirical models taken from the previous works. Several criteria were defined for the choice of the two-term model as being the one that can describe in the best way, the drying of the fish in both conditions. The effective diffusivity was determined using Ficks diffusive model whose solution is given by Crank, so that the logarithm of the reduced moisture allows us to find effective diffusivities for fish of 9.88823 10-7 (m²/s) and 1.72534 10-6 (m²/s) for open-air and in dryer drying respectively.
EFFECTIVENESS OF TOPICAL APPLICATION OF MIXTURE OF HONEY AND COFFEE IN RADIATION INDUCED ORAL MUCOSITIS AMONG PATIENTS WITH HEAD & NECK CANCER UNDERGOING RADIOTHERAPY AT RADIOTHERAPY DEPARTMENT OF KGMU, LUCKNOW, U.P
Authors:   M.Sc (N). Student, Department of Medical and Surgical Nursing, College of Nursing, KGMU, Lucknow, India., Verma Anjali , P. John Rashmi ,   Principal, Department of Medical and Surgical Nursing, College of Nursing, KGMU, Lucknow, India., Srivastava Kirti ,   M.D, Professor of Radiotherapy Department, KGMU, Lucknow, India.
Published: November 2020

Background: Cancers commonly known as head and neck cancers typically begin in the squamous cells that line the moist, mucosal surfaces within the head and neck. Oral mucositis is erythematous and ulcerative lesion of the oral mucosa in patients with cancer being treated with chemotherapy/ radiation therapy in the areas of oral cavity. Objectives: To assess the grade of the oral mucositis among head & neck cancer patients receiving radiotherapy. 2. To evaluate the effectiveness of mixture of honey and coffee application on radiation induced oral mucositis among the study group. 3. To find the association between the radiation induced oral mucositis with selected demographic variables. Method: quasi experimental non randomized control group design was applied and 60 samples (30 in each group) were selected by convenience sampling technique. The mixture of honey and coffee was applied to the study group before and after 15 minutes of radiotherapy till the continuation of radiotherapy and no intervention was given in the control group. Result: The result revealed that the application of honey and coffee mixture was significantly effective on oral mucositis (p<0.001) in the study group. Conclusion: The study concluded that, application of mixture of honey and coffee is an effective method of reducing the onset and severity of oral mucositis in comparison with no intervention.
Trend in global pharmaceutical market: COVID
Authors:   RM Analytics, Prozherina Yuliya
Published: November 2020

These days the impact of COVID-19 on the pharmaceutical market is becoming increasingly clear. The results of studies show similar trends in different countries against the backdrop of a pandemic that suddenly hit the world. It is obvious that currently COVID-19 has already had an unprecedented impact on the world [1].
Phosphogliv® URSO: a comprehensive approach to the treatment of biliary pathology
Authors:   Remedium, Shirokova Irina
Published: November 2020

Biliary diseases are the most important medical and social problem associated with a high prevalence among working age population and a significant decrease in patients’ quality of life. Modern therapy methods, including the latest advances in medical science, have sustained significant progress in the treatment of biliary pathology. The design and introduction into clinical practice of the original drug Phosphogliv URSO has become an important step in making progress in this direction.
A breakthrough in the treatment of chronic lymphocytic leukemia
Authors:   RM Analytics LLC, Prozherina Yuliya , Shirokova Irina ,   Remedium
Published: November 2020

Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults. Its prevalence is expected to increase alongside rising overall survival rates in patients with CLL achieved due to advances in therapy [1]. B-cell receptor signalling through Bruton’s tyrosine kinase (BTK) is one of the main pathways for the development of CLL. Acalabrutinib, the second-generation VTK inhibitor, has been made available recently to Russian patients, which presence in the market can improve the prognosis for such patients.
Study of main factors that lead pharmaceutical workers to change their jobs
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Dolova M.A. , Yagudina R.I. ,   Sechenov First Moscow State Medical University (Sechenov University), Gavrilina N.I. ,   Sechenov First Moscow State Medical University (Sechenov University)
Published: November 2020

Currently, the increase in the efficiency of pharmacy organizations is due to the efficiency of team management. Each pharmacy organization strives to strengthen the workforce and monitors staff turnover rates, because this can affect the economic results of the organization. The most effective tool for preventing the layoff of staff turnover. This article presents the results of a sociological study of the factors that lead pharmaceutical workers to change jobs. The objects of the study were pharmaceutical workers of pharmaceutical organizations of various organizational and legal forms in Moscow. The methodological basis of the research was formed by general theoretical methods of information processing: analysis, systematization, grouping, comparison and generalization. Based on the analysis of 214 questionnaires of pharmaceutical workers, the frequency of job changes was revealed, and this indicator wa s studied depending on the length of service. It was found that pharmaceutical workers with higher education are more committed to the pharmaceutical industry, but at the same time, one in three of them expressed a desire to change jobs while remaining in the profession. The analysis of value-oriented factors made it possible to identify the main reasons leading pharmaceutical workers to change jobs.
CONSIDERAÇÕES SOBRE A REDE DE ENFRENTAMENTO À VIOLÊNCIA CONTRA AS MULHERES
Authors: Santo Joyce Duailibe Laignier Barbosa , Santos Cristina Vianna Moreira dos
Published: November 2020

O objetivo desse artigo é refletir sobre a importância da gestão na articulação da rede no processo de enfrentamento à violência contra as mulheres, buscando informações a respeito dessa temática em estudos bibliográficos, livros e revistas científicas, por meio da metodologia revisão narrativa. Busca-se também, por meio deste artigo, apresentar informações referentes à contextualização da problemática da violência no Brasil, a legislação vigente contra situações de violência e a importância da rede de enfrentamento. A discussão é essencial diante dos inúmeros casos que se apresentam e do crescente fenômeno da violência no cenário nacional. Conclui-se que esse fenômeno complexo e constante deve ser entendido como um problema de saúde pública que exige cada vez mais reflexões aprofundadas e ações efetivas. A proposta não é esgotar o tema, mas trazer uma reflexão à luz de diversos teóricos e uma discussão a respeito da importância da gestão atuante de maneira ativa no processo de enfrentamento à violência contra as mulheres.
REABILITAÇÃO PULMONAR COM TREINAMENTO DE EQUILÍBRIO EM PACIENTES COM DOENÇA PULMONAR OBSTRUTIVA CRÔNICA: UMA REVISÃO SISTEMÁTICA
Authors: Dos Santos Tamires Daros , Oppitz Sheila Jacques , Albuquerque Yessa Do Prado , Pasqualoto Adriane Schmidt , Da Silveira Aron Ferreira , De Albuquerque Isabella Martins
Published: November 2020

O objetivo do estudo foi revisar sistematicamente a literatura sobre a eficácia da adição do treino de equilíbrio (TE) em programas de reabilitação pulmonar (RP) comparado a RP convencional na melhora do equilíbrio postural de indivíduos com doença pulmonar obstrutiva crônica (DPOC). A estratégia de busca foi realizada nas bases de dados PubMed/MEDLINE, SciELO, LILACS, PEDro, Scopus e Web of Science, sem restrição quanto ao ano de publicação ou idioma, conforme recomendações do PRISMA. Os critérios de inclusão contemplaram: ensaios clínicos envolvendo o TE na RP para melhora do equilíbrio postural em sujeitos com DPOC, publicados até junho de 2019. Dois revisores selecionaram os estudos, extraíram os dados e avaliaram o risco de viés, utilizando o Handbook da Cochrane, de forma independente. Dos 172 estudos potencialmente elegíveis, 2 foram incluídos, compreendendo um total de 107 pacientes com DPOC, dos quais 56 foram alocados no grupo intervenção (TE adicionalmente à RP convencional) e os demais foram inseridos no grupo controle (RP convencional). O TE adicionalmente a RP propiciou melhora no equilíbrio postural em relação à RP convencional, entretanto não foram encontradas diferenças significativas entre os grupos quanto ao nível de confiança na realização de atividades específicas e tolerância ao exercício. Os estudos apresentaram baixo risco de viés (alta qualidade). Sugere-se que a adição do TE em programas de RP convencional seja mais eficaz na melhora do equilíbrio postural em comparação à RP convencional. Entretanto, devido ao reduzido número de estudos disponíveis, não há evidência robusta para tomada de decisão clínica.
RELAÇÃO ENTRE FUNCIONALIDADE E IDADE LINGUÍSTICA EM CRIANÇAS COM SÍNDROME DE DOWN
Authors: Santos Diogo Ribas dos , Halberstadt Bianca , Moraes Anaelena Bragança de , Souza Ana Paula Ramos de
Published: November 2020

Objetivo: analisar o desempenho funcional e sua correlação com a idade linguística de crianças na faixa etária de um a sete anos, com diagnóstico de Síndrome de Down (SD). Método: Trata-se de um estudo transversal, descritivo, de abordagem quantitativa. Foram utilizados os instrumentos de Avaliação do Desenvolvimento da Linguagem (ADL), o Pediatric Evaluation of Disability Inventory (PEDI) e um questionário com dados sociodemográficos construído pelos pesquisadores. Resultados: Participaram da pesquisa 23 crianças com SD, com média de 3,6 anos de idade cronológica e média de 2,2 anos de idade linguística. As crianças apresentaram maior independência na área de mobilidade e maior atraso na área de autocuidado. Observou-se que quanto maior a idade cronológica, menor os escores em autocuidado e função social. Além disto, as crianças com maior idade linguística possuem maior mobilidade. Conclusão: Houve correlação positiva entre idade linguística, mobilidade e autocuidado.
DESENVOLVIMENTO PSICOMOTOR DE CRIANÇAS COM BAIXO PESO
Authors: Sousa Marilia Rocha de , Anastácio Zélia Ferreira Caçador , Braide Andrea Stopiglia Guedes
Published: November 2020

OBJETIVO: Avaliar o desenvolvimento psicomotor de crianças com baixo peso. METODOLOGIA: Estudo de campo, descritivo, observacional, transversal e com abordagem quantitativa, realizado no período de abril a julho de 2017, no Instituto da Primeira Infância. Foi aprovado pelo parecer 2.007.070/2017, seguindo a Resolução 466/12. Foram avaliadas 34 crianças com a faixa etária de 4 a 6 anos, utilizando a Bateria Psicomotora de Vitor da Fonseca – adaptada. Os dados foram analisados pelo software Statistical Packcage for the Social Sciences versão 20.0. RESULTADOS: Predomínio do gênero feminino, da faixa etária de seis anos e da renda mensal de até 1 salário mínimo. Do total de participantes, observou-se que 20 (59,8%) apresentaram o perfil dispráxico, 12 (35,2%) o perfil normal e duas (5,9%) o perfil bom. Correlacionando os fatores psicomotores com o perfil, observou-se que, com exceção da tonicidade, todos os outros seis fatores (equilíbrio, lateralidade, noção de corpo, estruturação espácio-temporal, praxia global e fina) obtiveram valores com a prevalência de pontuação 1 e 2, definindo um déficit psicomotor decorrente do baixo peso. Foi constatado também que 16 (57,1%) crianças, mesmo com a recuperação do estado nutricional, ainda apresentavam o perfil dispráxico. CONCLUSÃO: É possível através de ações conjuntas de acompanhamento nutricional e intervenção da psicomotricidade, reestabelecer o quadro de baixo peso e favorecer uma intervenção direcionada para o desenvolvimento psicomotor da criança.
A PRÁTICA DE UM PROGRAMA PREVENTIVO MELHORA A CAPACIDADE FUNCIONAL DE MEMBROS INFERIORES EM ATLETAS
Authors: Portuguez Nadine Castro , Lara Simone , Teixeira Lilian Pinto , Oliano Vinícius Jardim
Published: November 2020

O objetivo desse estudo foi analisar os efeitos de um programa preventivo sobre a capacidade funcional de membros inferiores em atletas jovens de handebol feminino. Este estudo experimental incluiu uma amostra por conveniência de 17 atletas com idade de 12 a 16 anos, integrantes de um time de handebol feminino amador. As jovens foram divididas em dois grupos, sendo, o grupo intervenção (GI), integrando as atletas que praticaram o programa preventivo associado ao treino regular do handebol (n=9), e o grupo controle (GC), cujas jovens praticaram apenas o treinamento esportivo na equipe (n=8). Foi aplicado um questionário inicial, mensurado os dados antropométricos e a capacidade funcional dos membros inferiores foi avaliada através do Single Leg Hop Test, Timed Hop Test e Side Hop Test. O programa consistiu de aproximadamente 20 minutos de exercícios de aquecimento, força, agilidade e pliometria e equilíbrio, antes do treino regular do esporte, duas vezes por semana, durante oito semanas, totalizando 16 sessões. O GI apresentou melhorias significativas pós-intervenção em todos os testes realizados (p<0,05), em ambos os membros inferiores, diferentes do GC, no qual os resultados foram mais limitados. Oito semanas de treinamento de um programa preventivo melhorou significativamente a capacidade funcional de jovens atletas de handebol feminino, indicando que este tipo de intervenção é capaz de modificar positivamente os fatores de risco para o desenvolvimento de lesões de membros inferiores destas atletas.
What SDG6 is about: ‘sustainable management’ or ‘rational use’?
Authors: Demydenko Andriy
Published: November 2020

The paper describes the Global Water Partnership partner experience in the introduction of risk-based Integrated Water Resources Management (IWRM) into the Ukrainian water policy. We concluded that some proper ‘expressions’ and concepts have already been introduced into Ukrainian legislation, but not the accepted ‘meanings’ of such concepts as IWRM, Sustainable Development Goals (SDG), and water security. The concept of ‘sustainable management’, in the Russian version of Water SDG6, is translated as ‘rational use’ but no one can explain why. We suggest that such a misunderstanding happened since Ukrainian decision-makers still perceive themselves only as water users who are not obligated to achieve any development goals. Therefore, they are quite comfortable with the existing normative approach to water management where the objectives are compliance with defined norms and ensuring water security, which is understood as an absence of any water risk solely to humans, rather than the environment at large. Keeping in mind that true science starts with measurable values, and recognizing that you cannot manage if you cannot measure, we propose to change this false understanding of water security and sustainability that is inherent in the outmoded concept of ‘rational use’. Such a shift is only possible by switching to a measurable goal-oriented approach and risk management in water policy.
Evaluation of Proteolytic and Chitinolytic Activities of Indigenous Bacillus Speciesfrom Crab Shell Waste
Authors:   Department of Biology, University of Brawijaya, Dliyauddin Moh , Ardyati Tri , Suharjono Suharjono
Published: November 2020

The increase of crab meat export activities in Indonesia leads to the accumulation of crab shell waste in a massive amount that can naturally degrade and causing bad odor. Naturally, microorganisms will degrade this waste through fermentation and enzymatic reaction, including protease and chitinase due to its high content of chitin and protein. Bacillus is the most potential bacteria to degrade crab shell waste, and indigenous Bacillus from this waste can increase the degradation rates. The aims of this study were to evaluate the proteolytic and chitinolytic activities of indigenous Bacillus species from crab shell waste. Bacillus cereus BP14 and Bacillus licheniformis CK20 as the chitinolytic bacteria, and Bacillus subtilis AP9 and Bacillus licheniformis AP5 as the proteolytic bacteria were isolated from crab shell waste and identified based on the 16S rDNA sequences. The bacterial isolates were grown in skim milk broth for proteolytic characterization and colloidal chitin broth for chitinolytic characterization. The growth rates of each bacteria were determined through the growth curves. The enzymatic activities were determined based on the international standard for protease and chitinase enzyme activities together with growth curve sampling to determine the best incubation time for obtaining the highest enzymatic activities. From the shortest to the longest generation times of the Bacillus species obtained were B. subtilis AP9, B. licheniformis CK20, B. cereus BP14, and B. licheniformis AP5, respectively. The best incubation time for producing the highest enzymatic activity varied among species. However, the end of the logarithmic phase was similar. All of the Bacillus species obtained from this study exhibited chitinolytic and proteolytic activity. Therefore, it can be used as promising candidates of biodegradation agents inenhancing the degradation rates of crab shell wastes.
Repairing Cell Structure of Jejunum Tissue in RA-CFA Rat Model Improved by Caprine CSN1S2 Protein
Authors:   Department of Biology, University of Brawijaya, Zaidah Laili Nur , Soewondo Aris , Fatchiyah Fatchiyah
Published: November 2020

We aimed to analyze the effect of CSN1S2 protein in Etawah crossbred goat milk and yogurt on the histopathology of the jejunum and the amount of cell damage in Complete Freund's adjuvant (CFA)-induced rheumatoid arthritis (RA) rats. The rats were divided into six groups: the untreated control rats (C), control rats were given CSN1S2 protein from Etawah crossbred goat milk (CM) or yogurt (CY), RA rats, RA rats given CSN1S2 protein from Etawah crossbred goat milk (RAM) or yogurt (RAY). Hematoxylin-eosin staining was conducted for the histopathological analysis of jejunum. Statistical analysis was done using one-way ANOVA (a significance value of p ≤ 0.05) followed by the Tukey test. Our study observed that the control, CM, and CY group have a normal histological structure of jejunum. The damage to the jejunum structure was reported in the RA group. The milk CSN1S2 protein was able to improve the structure of jejunum villi and increase the normal cell number in the jejunum of the RA group, similar to control. The RAY group showed an impaired jejunum structure and a high number of necrotic cells as in the RA group.
Detection of Reproductive Status in Ongole Crossbred (PO) Cow Based On Vaginal Epithel Morphology and Profile Hormone
Authors:   Department of Biology, University of Brawijaya, Widyaningrum Yeni , Aulanni’am Aulanni’am , Marhendra Agung Pramana Warih
Published: November 2020

Hormonal fluctuations in livestock will affect vaginal cytology good overview on the condition of estrous until pregnancy. The purpose of this study was to determine the physiological condition of Ongole crossbred (PO) cow during estrous and determine pregnancy by the description of vaginal epithelial cells, progesterone, and estrogen hormone profiles. The materials were used 35 cows with physiological status (estrous, 5th pregnancy period, 16th pregnancy period, 22nd pregnancy period, and 60th pregnancy period). Samples of Vaginal smear were stained with Giemsa, then it was observed using a microscope, with 40 times magnification. The progesterone and estrogen were analyzed by the ELISA method. The parameters measured were the percentage of vaginal epithelial cells, such as (parabasal, intermediate, and superficial) started estrous phase until the time of pregnancy in cows (5, 16, 22, and 60 days), hormone concentration, as well as the presence or absence of leukocytes. The result showed the Ongole crossbred cow estrous phase percentage of superficial cells 56.27%±6.49 higher than 26.23%±7.98 intermediate cells, followed by parabasal cells 17.50%±4.74. While in Ongole crossbred that were 5th pregnancy period until the 60th predominantly intermediate cell 80.43%±1.31, then the superficial cells 18.09%±1.30 and 1.48%±0.04 parabasal cells. Progesterone concentration was 63.74±1.07 ng.mL-1 in estrus cows, and steadily increased 93.71±0.94 ng.mL-1 to 149.5±0.71 ng.mL-1 in pregnant cows (5-60 days). The concentration of high estrogen levels were 122.38 ± 0.63 ng.mL-1 in the estrous phase, then decreased 81.54±0.44 ng.mL-1 in the pregnancy phase. In conclusion, the concentration of hormone showed a diagnosis of pregnancy, which done by looking at changes in vaginal epithelial cells at the Ongole crossbred cow, and the cow estrous phase showed greater superficial cells compared by pregnant cows (5-60 days).
The Artificial Bee Colony (ABC) Algorithm for Estimating Parameter of Epidemic Influenza Model
Authors:   Department of Mathematics, University of Brawijaya, Nirmalasari Ririn , Suryanto Agus , Anam Syaiful
Published: November 2020

The Artificial Bee Colony (ABC) is one of the stochastic algorithms that can be applied to solve many real-world optimization problems. In this paper, The ABC algorithm was used to estimate the parameter of the epidemic influenza model. This model consists of a differential system represented by variations of Susceptible (S), Exposed (E), Recovered (R), and Infected (I). The ABC processes explore the minimum value of the mean square error function in the current iteration to estimate the unknown parameters of the model. Estimating parameters were made using participation data containing influenza disease in Australia, 2017. The best parameter chosen from the ABC process matched the dynamical behavior of the influenza epidemic field data used. Graphical analysis was used to validate the model. The result shows that the ABC algorithm is efficient for estimating the parameter of the epidemic influenza model.
Combination Moringa oleifera Extract and Ifalmin as Potential Formulation of Preventing Inflammation in Diabetic Mice Model
Authors:   Department of Biology, University of Brawijaya, Nilamsari Ruri Vivian , Adharini Wahyu Isnia , Lestari Noviana Dwi , Tsuboi Hideo , Rifa’i Muhaimin ,   Department of Immunology, Nagoya University Graduate School of Medicine
Published: November 2020

In Indonesia, the prevalence of diabetes mellitus hits 6.2%, making Indonesia one of the top ten diabetes mellitus countries. Efforts to prevent and treat people with diabetes in Indonesia are required to minimize that as well. One is through treatment with local herbal products such as Moringa oleifera (MO) and Toman fish extract (Channa micropeltes), called Ifalmin. The aim of this research is to investigate the potential role of a combination of Extract Moringa oleifera and Ifalmin to reduce inflammation in diabetes conditions. Diabetic mice were done by Streptozotocin (STZ) induction with a single-dose 145 mg.kg-1.Then, diabetic mice were given an oral treatment of combination MO extract and Ifalmin for 14 days. In this experiment combinations of MO extract and Ifalmin are divide into 3 dose, There are: dose 1 (800 mg.kg-1 : 800 mg.kg-1), dose 2 (650 mg.kg-1 : 650 mg.kg-1), and dose 3 (800 mg.kg-1 : 650 mg.kg-1). Immune cells originate from the spleen are stained by immunofluorescence antibodies and analyzed by flow cytometry with BD Cellquest ProTM software. The results showed an increase of expression pro-inflammatory cytokines IL-1β and IL-6 in diabetic mice compared to normal control. Only dose 1 and dose 2 has shown the capability to reduce the expression of IL-1β in diabetic mice. But, the combination of MO and Ifalmin has an antagonist effect on the expression of IL-6. The inhibitory mechanism can be assumed by the action of antioxidant compounds (Flavonoids and Alkaloids) in MO and Albumin compound in Ifalmin. Those combination act as exogenous antioxidant that help endogenous inside the body. A combination of MO extract and Ifalmin with a certain dosage was able to decrease proinflammatory cytokines IL-1β on the cells involved in innate immunity.
The Role of Moringa oleifera- Ifalmin® Formulation in Regulation of B220+IgM+ and B220+IgG+ in Diabetic Mice
Authors:   Department of Biology, University of Brawijaya, Adharini Wahyu Isnia , Nilamsari Ruri Vivian , Lestari Noviana Dwi , Widodo Nashi , Rifa'i Muhaimin
Published: November 2020

It has been known that the immunoglobulin levels were altered in diabetes mellitus (DM) conditions. This study aimed to evaluate the levels of immunoglobulins in DM mice after the administration of Moringa oleifera-Ifalmin® formulation (MI). Streptozotocin, at a dose of 145 mg.kg-1, was injected intraperitoneally to experimental mice to obtain diabetic mice. The groups were divided into normal mice, diabetic mice without treatment, diabetic mice with metformin treatment (307.5 mg.kg-1 BW), and diabetic mice with MI treatment at dose 1 (M:I= 800 mg.kg-1 BW: 800 mg.kg-1 BW), dose 2 (M:I= 615 mg.kg-1 BW: 615 mg.kg-1 BW), and dose 3 (M:I= 800 mg.kg-1 BW: 615 mg.kg-1 BW). Mice were orally treated by MI for 14 days. Subsequently, the levels of immunoglobulin IgM and IgG were evaluated using flow cytometry analysis. IgM and IgG levels were significantly lower in the DM group than the normal group. These results indicated that DM altered immunoglobulin levels. MI treatment for 14 days significantly increased the number of IgM and IgG at the level equivalent to the normal group and significantly different as compared to the DM group. Based on the results, MI can be used as an immunomodulatory agent in humoral immunity through the precise regulation of IgM and IgG.
Physiological and Genetic Variations of Amorphophallus variabilis in Bojonegoro based on Glucomannan Content, Calcium Oxalate and RAPD Markers
Authors:   Department of Biology, University of Brawijaya, Pambudi Achmad Yogi , Harijati Nunung , Arumingtyas Estri Laras
Published: November 2020

This study had purpose to determine the glucomannan and calcium oxalate content in 7 variants of A. variabilis and their genetic relationships based on RAPD markers. Amorphophallus variabilis Tuber samples were taken from Karangdowo village, Sumberrejo Sub-district, Bojonegoro District, East Java. Each variant was analyzed for its glucomannan content by the spectrophotometric method using 3,5-DNS reagents and calcium oxalate by the 0.1N KMnO4 titration method. Leaf DNA extraction was carried out using the CTAB method. Relationship analysis used RAPD markers with 5 primers (OPA-11, OPC-04, OPU-06, OPC-07, and OPN-1). The obtained data were analyzed using the Numerical Taxonomy and Multivariate System (NTSYS-pc) version 2.1. The grouping of glucomannan content or oxalium[O1] oxalate used hierarchical clustering analysis (SPSS 16.0). This research found that the calcium oxalate content in seven variants of A. variabilis ranged from 0.01 to 0.03 g, where the variant with the lowest calcium oxalate is V6 with a value of 0.01 g and the highest is the V7 variant with a value of 0.03 g, while the glucomannan content ranges from 9 - 38%. The highest glucomannan content is V3, while the lowest is V6. Phenograms formed based on RAPD markers showed the formation of two groups of A. variabilis. Group one has two subgroups. Subgroup one consists of variants V1 and V4, while subgroup two consists of V6 and V7. Meanwhile, the second group consists of variants V2, V3, and V5. The seven variant grouping pattern of A. variabilis based on RAPD markers has no similarity to the grouping pattern based on the results of glucomannan or calcium oxalate analysis.
The Effectiveness of Combination of Momordica charantia Extract and Averrhoa bilimbi on Nf-Kb Activation in Mice (Mus musculus) Balb/C Hyperglycemia Models
Authors:   Department of Biology, University of Brawijaya, Sampurna Intan Sartika Risky , Rifa’i Muhaimin , Rahayu Sri
Published: November 2020

Hyperglycemia is a medical condition when the blood glucose levels increase exceeds the reasonable limit. Hyperglycemia is a typical sign of diabetes mellitus (DM). Indonesia is the sixth-ranked country in the world after China, India, United States, Brazil, and Mexico. Treatment with herbs is currently being developed. Pare (Momordica charantia) and Belimbing wuluh (Averrhoa bilimbi) are plants that found around us. Some studies state that each of these plants can be anti-diabetic. The hyperglycemia can cause an immune system disorder characterized by pancreatic β cell death involving IL-1β, kappa B (NF)-κB nuclear factor, and Fas. The ability of NF-kB activation will affect the number of cytokines expressed by T cells, namely TNF-α, and IFN-γ. The purpose of this study is to determine the effect of NF-kB activation on blood glucose levels in hyperglycemia mice. The results showed that the positive control treatment showed an increase in the number of NF-kB activations in CD4 and CD8 cells. EPBW (combination of Averrhoa bilimbi extract and Momordica charantia) administration results at a dose of 10 mg.kg-1 BW showed a reduction in the amount of activated NF-kB as a substitute for the reduction. In addition, that dose can reduce blood sugar levels in mice hyperglycemia model.
Family Firms and Negative Social Capital: A Property Rights Theory Approach
Authors: Lesteer Monica , Maheshwari Sharad K. , McLain P. Michael
Published: November 2020

Unlike non-family firms, family firms are highly affected by the dynamics of the family. Furthermore, there are differences between minority family firms and non-minority family firms. These differences between the operational performance of non-minority family firms and minority family firms’ exist due to the family’s tendency to behave collectivistic versus individualistic when extending property rights. Hence, utilizing the property rights theory, this article explains how differences in size, longevity, and financial wealth between non-minority family firms and minority family firms may be better understood by examining the family culture.
Videoconferencing-Based Telemental Health: Important Questions for the COVID-19 Era From Clinical and Patient-Centered Perspectives
Authors: Chiauzzi Emil , Clayton Ashley , Huh-Yoo Jina
Published: November 2020

The COVID-19 pandemic has intensified the search for digital approaches in mental health treatment, particularly due to patients and clinicians practicing social distancing. This has resulted in the dramatic growth of videoconferencing-based telemental health (V-TMH) services. It is critical for behavioral health providers and those in the mental health field to understand the implications of V-TMH expansion on the stakeholders who use such services, such as patients and clinicians, to provide the service that addresses both patient and clinical needs. Several key questions arise as a result, such as the following: (1) in what ways does V-TMH affect the practice of psychotherapy (ie, clinical needs), (2) to what extent are ethical and patient-centered concerns warranted in terms of V-TMH services (ie, patient needs), and (3) how do factors related to user experience affect treatment dynamics for both the patient and therapist (ie, patient and clinical needs)? We discuss how behavioral health providers can consider the future delivery of mental health care services based on these questions, which pose strong implications for technological innovation, the adaptation of treatments to new technologies, and training professionals in the delivery of V-TMH services and other digital health interventions.