bluuebunny/crossref_metadata_2025 huggingface dataset:
GENDER AS А DETERMINANT OF PARENTS AND CHILDREN’S ATTITUDES TOWARD THE INCLUSION OF SPORTS BRANCHES INTO THE ELEMENTARY SCHOOL CURRICULUM
Authors: Petrović Jelena , Momčilović Vladimir , Pelemiš Vladan
Published: June 2023

In Serbia’s elementary schools, physical education is an obligatory course from the very beginning of education. This is why schools and academic staff can use their authority and behaviour to promote a healthy lifestyle among children. Parents, who are the models of good behaviour, opinions, and attitudes, likewise participate in the promotion of a healthy lifestyle among children. Thus, so as to ensure that the process of building healthy habits and an active lifestyles is as successful as possible, it is important to bear in mind the interests and preferences of both groups, as well as their gender differences. The research sample included 8002 schoolchildren in their fifth year of education, and 5768 parents. The independent variables were gender and participation in sport, and the dependent variables were 27 sport activities. The data was processed using non-parametric statistics, χ² and crosstabs. The results show that soccer, basketball, swimming and volleyball are the sports which schoolchildren most like to participate in, and which parents prefer for their children. In terms of the choice of sport, significant differences were determined between the boys and the girls, as well as between the mothers and the fathers.
THE CHALLENGES OF TEACHING NATIVE AMERICAN LITERATURE AS PART OF THE NINETEENTH CENTURY AMERICAN LITERATURE COURSE
Authors: Izgarjan Aleksandra
Published: June 2023

This paper focuses on the challenges of including Native American literature in the course on nineteenth century American literature. Survey literature courses often feature canonical works and exclude minority or contrarian voices. My literature survey course includes the creation stories of four Native American tribes originating from different parts of the U.S., together with the works of contemporary Native American writers reflecting on the pre-colonisation and colonisation periods of American history. The process of teaching the course foregrounded the tensions between the dominant white settler mentality and the political and social marginality of Native Americans, making my students aware of the importance of multivalent analyses of literary and historical texts. Throughout the course, we discussed prevalent stereotypes about Native Americans in American literature. The experience of teaching this course leads me to the conclusion that it is important to discuss various marginalised voices in the survey courses on nineteenth century American literature. These texts reflect themes related to race, gender, religion, and ownership of land that go beyond literature to include social, political and historical issues, helping our students develop a better understanding of American culture.
DOES OWNERSHIP TYPE MATTER FOR INNOVATIVENESS AND LEARNING ORIENTATION? EMPIRICAL EVIDENCE FROM SERBIA
Authors: Nikolić Jelena , Mirić Marija , Zlatanović Dejana
Published: June 2023

The turbulent business environement acknowledges innovativeness and learning as dominant success factors of modern business organizations. The differences in their innovativeness can be explained by the ownership structure, as an internal mechanism of corporate governance, with significant attention being paid to the ownership type. The paper seeks to identify potential differences in innovativeness and learning orientation among companies from the aspect of domestic and foreign ownership. The research sample consists of 71 companies operating in the territory of the Republic of Serbia. Primary data were collected by the survey method. An appropriate quantitative methodology was implemented in this empirical research. and analyzed with non – parametric Mann – Whitney U test. The results obtained revealed statistically significant differences in the level of innovation and learning orientation between domestically and foreign – owned companies. The originality of the research is reflected in the analysis of individual innovation dimensions, from the ownership type aspect, including product or service innovations, process and organizational innovations. By studying the link between learning orientation and type of ownership, the paper fills the identified research gap in the existing literature.
In-Vitro Evaluation of Anti-Glycation Potential of Bruguiera Sexangula
Authors: Priyadarsini Suman , Das Dr. Swagat Kumar
Published: June 2023

Diabetes mellitus (DM) is a metabolic disorder that affects people all over the world and causes hyperglycemia. Further, chronic hyperglycemia may lead to non-enzymatic protein glycation where the excess blood glucose reacts with free amino acids in proteins to form a labile Schiff's base. Then the base gets stabilized to form advanced glycation end products (AGEs), one of the hallmark compounds of glycation. Therefore, antiglycation therapy is considered as one of the important aspects of post diabetic treatment. Recently, many phytochemicals have been reported for their antiglycation potential. In the present study, Bruguiera sexangula an medicinal mangrove plant from the Eastern coastal regions of Odisha has been evaluated for its antiglycation potential using in vitro techniques. The anti-glycation activities of aqueous bark extract of this plant were determined by bovine serum albumin-fructose glycation model. The multistage glycation markers-fructosamines, thiols and β aggregation of albumin using amyloid-specific dyes–Congo red were evaluated. The studies were carried out for the 0th,1st, 2nd , 3 rd and 4th consecutive weeks. The present study showed aqueous bark extract of Bruguiera sexangula at 1mg/ml concentration could inhibit amyloid cross beta aggregation in the 0th, first, third and the fourth week. However, no inhibition was observed in the second week. On the other hand, the standard anti-oxidant compound Quercetin could inhibit the amyloid beta aggregation in all the 4 weeks in the Congo red assay. And the extract could only show amadori product inhibition potential during the 1st and the 4th week of study. While, the compound Quercetin could inhibit the amadori product in 1st, 3rd and 4th week of the fructosamine assay. Free thiols were significantly protected from oxidation by the plant extracts. The active phytocompounds were isolated by column chromatography by using different fractions of solvents (petroleum ether, chloroform and methanol) on the basis of their polarity and it is stored for further assays. The results of the present study indicated that B.sexangula can provide protection against long term glycation associated complications. However, more in depth studies need to be carried out to decipher its antiglycation potential. Further, the bioactive phytochemicals responsible for this activity may be isolated to access its antiglycation potential in suitable model organism.
Glass Virtual Try-On
Authors: Chauhan Peeyush
Published: June 2023

Abstract: Virtual try-on technology allows people to explore the look of accessories, makeup, hair extensions, hair color, clothing and much more for themselves. Virtual try-on offers many advantages over real attempts, speeding up the process gives you the opportunity to test hundreds of products without the need to access a real store. The test process is performed on a reconstructed 3D face from a embedded image that allows the user to see the visible face and mirrors with different views. The process is fully automatic and does not require the user to provide anything other than the image and the name of the glass frames for testing.
Diagnosis of Chronic Liver Disease using Machine Learning Techniques
Authors: Biju Kalyani
Published: June 2023

Abstract: Liver disease is one of the deadly diseases. This issue has been increasing all over the world. Liver disease is a process that may cause the destruction and regeneration of the liver parenchyma. Many diseases and conditions and also use of some drugs may also cause liver diseases. So early detection and treatment can recover the disease in its early stage. Machine learning algorithms like Logistic Regression, KNN and Random Forest algorithms can be applied to detect the liver related diseases. Four stages of liver diseases such as healthy liver, fatty liver, liver fibrosis and liver cirrhosis are detected in this system. Liver disease prediction involve various steps such as pre-processing, feature extraction and classification. Datasets are collected from the Kaggle database of Indian liver patient records
Missing Child Identification using Convolutional Neural Network
Authors: Raghavendra M.
Published: June 2023

The goal of this study is to locate missing children from a big dataset of child photographs using a novel application of deep learning algorithms. The method makes use of facial recognition to precisely identify a missing child from a dataset of missing child photographs and trains a deep learning model to do so. Convolutional Neural Network (CNN), a potent approach for image-based applications, is the method used.
Image Captioning Using Deep Learning
Authors: Wasi Md Adnan , Das Rakesh , Sarkar Purnendu , Singha Suvajit , Barman Tanmay , Kundu Sourov Kumar , Dhar Moloy , Chaudhuri Sayan Roy
Published: June 2023

Abstract: This paper focuses on developing an image captioning system using deep learning techniques. The paper aims to generate descriptive textual captions for images, enabling machines to understand and communicate the content of visual data. The methodology involves leveraging convolutional neural networks (CNNs) for image feature extraction and recurrent neural networks (RNNs) for sequential language generation. The paper includes steps such as dataset collection, data preprocessing, CNN feature extraction, RNN-based captioning model implementation, model evaluation using metrics like BLEU score and METEOR, and presenting the results obtained. The expected deliverables include a functional image captioning system, comprehensive documentation, and a well-documented codebase. Through this paper, students gain practical experience in deep learning, computer vision, and natural language processing, contributing to advancements in image understanding and humanmachine interaction with visual data
Urgensi Media Pembelajaran Audio Visual Berbasis Digital pada Pembelajaran Ilmu Pengetahuan Alam di Sekolah
Authors: Ade Suryanda  , Rosariyantika Windi , Ratna Komala  , Eka Putri Azrai
Published: June 2023

Latar Belakang: Latar Belakang: Media pendidikan diartikan sebagai pembawa atau penyalur pesan yang memuat sumber-sumber informasi untuk disampaikan kepada siswa. Agar kualitas lingkungan belajar menjadi baik dan sesuai serta berpengaruh secara signifikan terhadap proses pembelajaran, maka perlu dipilih lingkungan belajar yang mendukung proses pembelajaran. Kemajuan teknologi dan ilmu pengetahuan telah memberikan dampak yang sangat besar terhadap penggunaan media di sekolah. Namun, sebagian guru di sekolah Indonesia masih belum memiliki keterampilan dalam menggunakan teknologi. Agar siswa dapat menerima materi pendidikan yang disampaikan, diperlukan media yang tepat untuk membantu penyampaian materi, khususnya materi ilmiah.  Metode: Penelitian ini menggunakan metode deskriptif kualitatif. Instrumen data berupa kuesioner dan daftar wawancara. Kemudian data dianalisis dengan menggunakan teknik analisis data Miles dan Huberman (199). Hasil: Hasil penelitian menunjukkan bahwa hampir 100% siswa memiliki smartphone atau laptop atau tablet sendiri. Sekitar 52% siswa menggunakan smartphone atau laptop atau tablet selama 6-12 jam sehari, yang digunakan untuk belajar (92,9%), bermain (96,9%), mencari informasi (92,1%) dan berkomunikasi (89%). Mata pelajaran Ilmiah dianggap sebagai mata pelajaran yang sulit (62,2%); parah (17,3%) dan sangat parah (13,4%). Kesimpulan: Urgensi penggunaan media pembelajaran audio visual berbasis digital dalam proses pembelajaran materi IPA memiliki kedudukan yang sangat signifikan, bahkan peran media sejajar dengan metode dalam suatu proses belajar.
Stages of Microspore Development in Eggplant (Solanum melongena L.)
Authors: Devi Bunga Pagalla
Published: June 2023

Background: Microspores are small haploid spores that develop into the male gametophyte. Microsporocytes undergo meiotic division to form microspores. Microspores can be found in seedless and seed plants. The microspores in each flowering plant are different. This study aims to observe microspores on eggplant flowers. Method: Microspore observations were carried out on different flower bud sizes until the flower buds bloomed. Result: The results showed microspores in eggplant had different stages of development for each flower bud size. The stages of microspore development observed were Early uninucleate (Young microspore), Mid-uninucleate, Late uninucleate (Vacuolate microspore), early binucleate (Young bicellular pollen), mid-binucleate, and mature pollen. Conclusion: In eggplant microspore culture, anther length is a strong parameter to predict the stage of microspore development contained there in.
Isolasi dan Karakterisasi Bakteri Rizosfer Pohon Kamboja (Plumeria acuminata) di TPU Pracimaloyo sebagai penghasil IAA
Authors: Putra Sahasika Sean , Rahayu Triastuti , Tyastuti Erma Musbita
Published: June 2023

Latar Belakang: Tempat pemakaman umum (TPU) adalah lokasi penguburan jenazah dan terjadi dekomposisi jasad secara aktif menghasilkan nutrisi dan mineral tanah yang mendukung pertumbuhan makhluk hidup di sekitarnya termasuk bakteri dan pohon Kamboja. Pohon Kamboja dikenal tahan terhadap cekaman biotik maupun abiotik yang mumgkin dipengaruhi keberadaan bakteri rizosfer sebagai plant growth promoting rhizobacteria (PGPR). Berdasar penelusuran referensi, belum ditemukan penelitian yang membahas tentang bakteri rizosfer pohon kamboja di tanah pemakaman. Penelitian ini bertujuan untuk isolasi dan karakterisasi bakteri rizosfer pohon Kamboja dari tanah makam yang berpotensi menghasilkan IAA. Metode: Sampel tanah rizosfer diambil dari TPU Pracimaloyo Surakarta Jawa Tengah pada 5 titik yang  menempel pada permukaan akar pohon kamboja untuk diinokulasi menggunakan metode cawan tebar pada pengenceran 10-5 dan 10-6 di media NA (nutrient agar).  Setelah 48 jam, koloni dihitung untuk mendapatkan data populasi. Kemampuan bakteri rizosfer sebagai penghasil IAA dilakukan secara kualitatif dan kuantitatif pada umur kultur 24 dan 48 jam. Isolat bakteri rizosfer potensial menghasilkan IAA dikarakterisasi secara makroskopis (morfologi koloni) dan mikroskpis dengan pewarnaan Gram. Hasil: Populasi bakteri rizosfer pohon kamboja di semua blok tidak menunjukkan perbedaan yang signifikan dan terdeteksi memiliki populasi antara 1,9 – 10,4 x 106. Uji kualitatif kemampuan menghasilkan IAA, terdeteksi 34,88% isolat menghasilkan IAA sangat tinggi. Konsentrasi IAA paling tinggi dihasilkan oleh isolat P37, diikuti P38 dan P24 pada umur 48 jam adalah 113,58 ppm, 77,95 ppm dan 55,69 ppm.  Semua isolat potensial menghasilkan IAA merupakan bakteri gram negatif berbentuk kokus. Kesimpulan: Populasi bakteri rizosfer pohon kamboja di TPU Pracimaloyo berkisar antara 1,9-10,4 x 106 CFU/g dan 34,88% mempunyai kemampuan menghasilkan IAA.  Konsentrasi IAA yang dihasilkan lebih tinggi pada umur kultur 48 jam dibanding 24 jam dengan konsentrasi tertinggi oleh isolat P37 (83,098 ppm dan meningkat menjadi 113,588 ppm). Isolat P37 merupakan bakteri Gram negatif berbentuk kokus dan koloni irregular.
Development of Animated Video Learning Media Using the Powtoon Application on the Theme of Caring for Living Things
Authors: Bunga Indri Pertiwi  , Isti Rusdiyani  , Lukman Nulhakim
Published: June 2023

Background: The background of this research is (1) the lack of availability of learning media (2) the lack of student motivation to participate in the learning process; and (3) Science learning outcomes are still not optimal. This study aims to develop learning media, analyze feasibility, analyze effectiveness, and analyze students' responses to learning media using animated videos Powtoon on caring for living beings. Methods: Research and Development (R&D) 4-D approach. The final findings in this research and development are limited student trials of products in the form of animated video learning media using applications Powtoon for students of class IV Public Elementary School Cibeber District. Results: Effectiveness trials at the development stage were carried out by researchers by doing pre-test and post-test. The known value pre-test obtains an average value of learning outcomes of 55.68. As for value, the post-test received an average score of 79.37 learning outcomes, with the number of respondents or students used as test subjects as many as 80 students from four schools. In the subsequent trial, the researcher distributed questionnaires to teachers and students. This questionnaire is limited to knowing the responses and responses of students at the dissemination stage of using animated video learning media Powtoon by getting the results of the average percentage of teacher and student responses to enthusiastic video learning media, which reached 94% in the "excellent" category. Conclusions: Thus, using the animated video learning media Powtoon developed is suitable for the learning process.
política minera neoliberal
Authors: Ortiz Morales Ximena
Published: June 2023

Este artículo tiene por objetivo evidenciar el cambio en la política minera expresado en la legislación propugnada por los neoliberales involucrados en la dictadura cívico-militar chilena. Dando cuenta de algunos debates desarrollados entre militares y civiles como expresión de las tensiones que se desarrollaron en el encuentro de dos miradas diferentes en la junta militar.
Del campo de cultivo al campo de batalla
Authors: Godoy Orellana Milton
Published: June 2023

El artículo analiza el impacto de la Primera Guerra Mundial en uno de los puertos de la región salitrera de Chile. en el contexto de un mercado mundial capitalista e integrado las potencias europeas y los intentos de asegurar sus vías de aprovisionamiento e impedir que llegaran a sus adversarios.
Esta confrontación tuvo un negativo impacto en la economía de la región salitrera dada la alta necesidad del abastecimiento de nitrato durante el conflicto y la cuestionada neutralidad chilena. Por último, se analiza las repercusiones socioeconómicas del conflicto en el sector meridional del desierto de Atacama, cerrando con algunas conclusiones que pretenden aportar a esclarecer este problema.
BULLYING BEHAVIOR IN SCHOOLS IN THE PERSPECTIVE OF ISLAMIC PSYCHOLOGY
Authors: Anjasari Titi , Rahmatullah Azam Syukur
Published: June 2023

Bullying behavior in schools has been going on for a long time and is still growing today. The purpose of writing this article is to discuss bullying behavior in schools in the perspective of Islamic Psychology. The method used in this writing is the study of libraries by taking literature from the Quran and Hadith, journals through google scholar and scopus, news and related books. The results of this study show that bullying behavior in schools in the perspective of Islamic Psychology is abusive behavior that a person does to others in verbal or physical form according to an Islamic point of view. This behavior can result in mental disorders even to suicide. Efforts to overcome bullying are to instill awareness as early as possible about the bullying virus and give love to children. For victims of bullying who experience mental disorders are given guidance and forgiveness techniques, al-Tasywiq and al-Tadzkir, Tsawab and Iqab, tazkiyah and ta'lim al-hikmah.
PATIENCE AND PSYCHOLOGICAL WELFARE ON STUDENTS WORKING PART-TIME DURING COVID-19 IN BANDA ACEH
Authors: Safrilsyah Safrilsyah , Fitri Putri Rahma , Karjuniwati Karjuniwati
Published: June 2023

Psychological well-being is one of the most important things in human life, especially for students working part-time during COVID-19. One of the factors that can affect psychological well-being is patience. The purpose of this study was to determine the relationship between patience and psychological well-being in UIN Ar-Raniry students working part-time during COVID-19. This study uses a correlational quantitative approach. The measuring tools in this study are the patience scale from Subandi (2011) and the psychological well-being scale from Ryff and Singer (2008). . The sample in this study were 211 people. Sampling using non-probability sampling method with accidental sampling technique. The results of this study show a correlation coefficient of r = 0.839 with p = 0.000 (p < 0.05) which indicates that there is a very significant positive relationship between patience and psychological well-being in UIN Ar-Raniry students working part-time during covid-19. This means that the higher the patience, the higher the psychological well-being felt by students and the lower the patience, the lower the psychological well-being felt by the students.
DOES AUTHORITATIVE PARENTING STIMULATE CAREER DECISION SELF-EFFICACY IN ADOLESCENT?
Authors: Kumala Intan Dewi , Afriani Afriani
Published: June 2023

Abstrak: Pada masa remaja akhir, kemampuan untuk menentukan atau mengambil keputusan terkait karir yang akan dijalani merupakan satu diantara tugas perkembangan yang penting dikuasai. Pada prosesnya tipe pengasuhan orangtua memainkan peran sentral dan berkontribusi dalam membentuk tingkat keyakinan remaja tentang dirinya dalam membuat keputusan karir yang dianggap sesuai. Penelitian ini bertujuan untuk mengetahui hubungan antara tipe pengasuhan otoritatif dan efikasi keputusan karir pada remaja di Aceh. Multi stage cluster dan Disproportionated stratified random sampling digunakan sebagai metode pengambilan sampel dalam penelitian ini dengan total sampel sebanyak 347 remaja berusia 18-21 tahun yang terkumpul dari sembilan wilayah terpilih di provinsi Aceh. Parental Authority Questionnaire (PAQ) dan Career Decision Self-Efficacy Short Form (CDSE-SF) digunakan sebagai instrumen pengukuran. Hasil penelitian menunjukkan terdapat hubungan antara kedua variabel dimana pengasuhan ayah otoritatif dan ibu otoritatif memiliki hubungan positif dan menunjukkan adanya korelasi yang kuat pada kedua variabel, dengan r= 0,797 (p<0,05) pada pola asuh otoritatif ayah dan r= 0,804 (p<0,05) pada pola asuh otoritatif ibu. Hal ini dapat dimaknai bahwa semakin baik otoritas/pengasuhan orangtua tipe autoritatif menurut penilaian remaja maka, semakin tinggi keyakinan pada diri remaja dalam membuat keputusan karir (career decision self-efficacy). Kata kunci: Remaja, Otoritas Pengasuhan, Otoritatif, Efikasi Keputusan Karir. Abstract: Career decision making is one of the developmental tasks in adolescence, especially late adolescence (18-21 years), namely determining the specifications of the career that will be undertaken. In this process, the level of efficacy in adolescents are formed through the authoritative type of parental authority is taken into consideration. Parental authority has contributed to the level of adolescent efficacy in making career decisions appropriate. This study aims to determine the relationship between parental authority (authoritative parenting style) and career decision self-efficacy among adolescents in Aceh. The method used was multistage cluster and disproportionate stratified random sampling and data collection was carried out in nine selected areas in Aceh province with a total sample of 347 adolescents aged 18-21 years. The instrument used is the Parental Authority Questionnaire (PAQ) and the Career Decision Self-Efficacy Short Form (CDSE-SF). The results showed that there was a relationship between the two variables, namely a positive relationship between the authoritative father r= 0,797 (p<0,05) and the authoritative mother r= 0,804 (p<0,05) with the CDSE variable. This means that the better type of parental authority according to the adolescent's assessment, the higher efficacy adolescents have in making career decisions (career decision self-efficacy).  Key words: Adolescents;  Parental Authority : Authoritative;  Career Decision Self-Efficacy.
A Replication of the Ego-Depletion Effect: Control of Effort Engagement during the Depleting Task with Electroencephalography and Heart-Rate Variability
Authors: Daneshgar-Pironneau Sarvenaz , Audiffren Michel , Benraïss Abdelrahni , Métais Angèle , André Nathalie
Published: June 2023

The ego-depletion effect has been interpreted as a temporary failure of
self-control exertion after a first effortful task (Baumeister et al.,
2007). Although the existence of this effect was previously challenged
(Vohs et al., 2021), it was successfully replicated in a recent study
applying an adequate experimental protocol (Mangin et al., 2021). In the
present experiment, we applied a similar protocol while assessing the
electrophysiological changes in effort engagement through mid-frontal
theta and cardiac reactivity (Cavanagh & Frank, 2014; Mukherjee et al.,
2011). A total of 32 participants in a between-subjects design performed
the following task sequence: handgrip task at 13% of maximal voluntary
contraction, a 30-min mental task (depleting or control task) and the
handgrip task again (dependent task). The experimental group (N = 16)
performed a modified Stroop task, while the control group (N = 16)
watched an emotionally neutral documentary. EEG and ECG were recorded on
a continuous basis. We assumed to observe an increase in the
electrophysiological correlates of mental effort during the depleting
task and a performance decrement in the subsequent dependent task. For
the depleting condition, the behavioral results showed worse performance
in the subsequent dependent task and the EEG results showed higher
mid-frontal theta power. Heart-rate variability results showed an
increase in parasympathetic activity over time during the depleting
task. Therefore, the ego-depletion effect was once again successfully
replicated. The depleting task required more mental effort than the
control task, but a slight decrease in effort engagement over time was
also observed.
Evolutionary Geographic Changes of the Macaques in Mainland East Asia during the Quaternary and Their Prospective Conservation
Authors: Wang Hai tao , Zhang He , Zhang Hexian , Pan Hao , Hou Rong , Huang Kang , Guo Songtao , He Gang , Zhang Pei , Li Baoguo , Pan Ruliang
Published: June 2023

Understanding how ecological and environmental changes, anthropogenic
activities, and climate have driven and will direct animals’ development
and predicting their prospective distribution profiles in the Quaternary
are essential to making a tangible conservation strategy. Macaques
(Macaca) distributed in mainland East Asia provide an ideal
research model for such an effort. We reconstruct macaques’ geographic
distribution profiles during the Quaternary, from the last
inter-glaciation (LIG, 120,000 - 140,000 years BP), the Last Glacial
Maximum (LGM, 22,000 years BP), and the present (1970-2000) – based on
which we deduce their perspective distribution in the 2050s. The results
show their suitable habitats during LIG and LGM were mainly in
Southwest, Central, and Coastal China. A noticeable distribution
reduction started in LIG and persisted until the current (1970-2000).
Their distribution centroid would shift northward to mountainous
regions, mainly in Southwest China, where more migration corridors would
be reserved for their future development. Also, the results indicate
that China’s Protected Area currently does not cover more than 87% of
macaques’ habitats, a dismal situation for their conservation. Finally,
this study proclaims that the conservation priority of the macaques in
the years to come should focus on Southwest China – their future refuge
region in Quaternary.
Biochemical, Histopathological and Immunohistochemical study of the repeated environmental toxicant Ultra Violet B radiations induced Hyperthyroidism alleviates oxidative stress and prevented by Naringin in male Swiss albino mice
Authors: SHAKYAWAL SHASHANK , RAI GAYATRI , MAHOBIYA PAYAL
Published: June 2023

Global warming rise has been observed as a result of ozone layer
destruction, which makes it possible for UVB radiation to pass through
atmosphere and kill people. It is believed that daily exposure to UVB
radiation has biological effects on both humans and other living things.
Concerning effect of UVB radiations, we examine the instinctive
mechanism by which a specific amount of radiation induces oxidative
stress and hyperthyroidism, which is further controlled by the
antioxidant activity of Naringin (NG), due to the detrimental effects of
UVB radiation on the biological system. For these examinations
twenty-four adult male albino mice were divided into four equal groups;
control group, UVB exposed group (2 hrs/day), UVB+NG treated group (80
mg/kg b.w), and NG-treated group. Doses were given orally, daily for 15
consecutive days. Specimens of the thyroid gland were processed for
hormonal, biochemical, histological, immunohistochemical and
immunofluorescence examinations. A morphometric study and statistical
analysis of the findings were performed for different groups. Compared
to the control group, the specimens of the UVB exposed mice showed
alteration in mean height of the thyroid follicular epithelial cells and
caspase-3, NOS-2 and THRβ-1 expression. In contrast, naringin prevent
the changes caused due to repeated UVB radiations.
Interpretation of In Vitro Concentration-Response Data for Risk Assessment and Regulatory Decision-making: Report from 2022 IWGT Quantitative Analysis Expert Working Group Meeting
Authors: Beal Marc , Chen Guangchao , Dearfield Kerry , Gi Min , Gollapudi Bhaskar , Heflich Robert , Horibata Katsuyoshi , Long Alexandra , Lovell David , Parsons Barbara , Pfuhler Stefan , Wills John , Zeller Andreas , Johnson George , White Paul
Published: June 2023

Quantitative risk assessments of chemicals are routinely performed in
rodents; however, there is growing recognition that non-animal
approaches can be human-relevant alternatives. There is an urgent need
to build confidence in non-animal alternatives given the international
support to reduce the use of animals in toxicity testing where possible.
In order for scientists and risk assessors to prepare for this paradigm
shift in toxicity assessment, standardization and consensus on in vitro
testing strategies and data interpretation will need to be established.
To address this issue, an Expert Working Group (EWG) of the 8th
International Workshop on Genotoxicity Testing (IWGT) evaluated the
utility of quantitative in vitro genotoxicity concentration-response
data for risk assessment. The EWG first evaluated available in vitro
methodologies and then examined the variability and maximal response of
in vitro tests to estimate biologically relevant values for the critical
effect sizes considered adverse or unacceptable. Next, the EWG reviewed
the approaches and computational models employed to provide
human-relevant dose context to in vitro data. Lastly, the EWG evaluated
risk assessment applications for which in vitro data are ready for use
and applications where further work is required. The EWG concluded that
in vitro genotoxicity concentration-response data can be interpreted in
a risk assessment context. However, prior to routine use in regulatory
settings, further research will be required to address the remaining
uncertainties and limitations.
No genetically predicted association between sarcopenia and COVID-19
Authors: Pan Hai-Feng , Tao Sha-sha , Xu Yi-Qing , Dai Xiao-Fan , Zhao Yan , Jiang Ling-Qiong , Fang Yang , Zhang Ruo-Di
Published: June 2023

Objectives: Previous observational studies have revealed a
connection between sarcopenia and COVID-19. To evaluate their causal
relationship, we utilized a bidirectional two-sample Mendelian
randomization (MR) analysis to study the link of cause and effect
between sarcopenia and COVID-19. Methods: Inverse variance
weighting (IVW), MR-Egger, weighted, and weighted median were used in
this research. Then we used the MR Pleiotropy RESidual Sum and Outlier
(MR-PRESSO) and MR-Egger regression methods to estimate the pleiotropy
of instrumental variables (IVs), while the outliers were excluded by
MR-PRESSO. Moreover, we used Cochran’s Q statistic to evaluate the
heterogeneity among the IVs. And we used leave-one-out sensitivity
analysis to identify the SNPs that significantly affect the outcomes.
Finally, the Bonferroni correction was used to correct each result.
Results: The IVW results suggested that faster WP decreased the
risk of all types of COVID-19 (COVID-19 infection: OR = 0.469, 95% CI:
0.326,0.676, P = 4.82E-05; COVID-19 hospitalization: OR = 0.247,
95% CI: 0.122,0.502, P = 1.11E-04; severe COVID-19: OR = 0.120,
95% CI: 0.046,0.314, P = 1.53E-05). However, there was no causal
relationship between ASM, LH or RH and COVID-19, and WP adjusted for BMI
had no significant connection with all types of COVID-19. Furthermore,
no causal association of COVID-19 on sarcopenia was observed in the
results of reverse MR analysis. Conclusion: Our bidirectional
two-sample MR study suggests the causal relationship between WP and
COVID-19 but it may be caused by the mediating role of BMI, thus there
is no causal association between sarcopenia and COVID-19.
Bringing equine adipose tissue into focus
Authors: McCullagh Sophie , Dosi Miranda , Keen John , Morgan Ruth
Published: June 2023

Adipose tissue is not only required for energy storage but is an
essential endocrine organ with a central role in the pathology of
obesity. The understanding of its role, both in human and equine
medicine, is continually evolving. With obesity being an ever-growing
problem in the equine population, gaining owner compliance is critical
when implementing management plans. The aim of this review is to
encourage the inclusion of the concept of adiposity in discussions with
horse owners on obesity and metabolic syndrome. In doing this, we hope
to improve clients understanding and therefore maximise the impact of
diagnostic tests, monitoring tools and management.
Heterogeneous responsiveness to environmental stimuli
Authors: Cavailles Jerome , Grube Martin , Kuzmics Christoph
Published: June 2023

Individuals of a species cope with environmental variability through
behavioral adjustments driven by individuals’ responsiveness to
environmental stimuli. Three key empirical observations have been made
for many animal species: The coexistence of different degrees of
responsiveness within one species; the consistency of an individual’s
degree of responsiveness across time; and the correlation of an
individual’s degree of responsiveness across contexts. Taking up key
elements of existing approaches, we provide one unifying explanation for
all three observations, by identifying a unique evolutionarily stable
strategy of an appropriately defined game within a stochastic
environment that has all three features. Coexistence is explained by a
form of negative frequency dependence. Consistency and correlation is
explained through potentially small, individual, differences of states
animals have and the resulting differential advantages they can get from
it. Our results allow us to identify a variety of testable implications.
Short-term Wind Power Prediction based on Combined LSTM
Authors: Zhao Zhao Yuyang , Li Li Lincong , Guo Guo Yingjun , Shi Shi Boming , Sun Sun Hexu
Published: June 2023

Wind power is an exceptionally clean source of energy, its rational
utilization can fundamentally alleviate the energy, environment, and
development problems, especially under the goals of “carbon peak” and
“carbon neutrality”. A combined short-term wind power prediction based
on LSTM artificial neural network has been studied aiming at the
nonlinearity and volatility of wind energy. Due to the large amount of
historical data required to predict the wind power precisely, the
ambient temperature and wind speed, direction, and power are selected as
model input. The CEEMDAN has been introduced as data preprocessing to
decomposes wind power data and reduce the noise. And the PSO is
conducted to optimize the LSTM network parameters. The combined
prediction model with high accuracy for different sampling intervals has
been verified by the wind farm data of Chongli Demonstration Project in
Hebei Province. The results illustrate that the algorithm can
effectively overcome the abnormal data influence and wind power
volatility, thereby provide a theoretical reference for precise
short-term wind power prediction.
Toward understanding the cross-linking from molecular chains to aggregates by engineering terminals of supramolecular hyperbranched polysiloxane
Authors: yuanbo zhang , Yuan Junshan , Hu Jingzhi , Tian Zhixuan , Feng Weixu , Yan Hongxia
Published: June 2023

Crosslinking thermosets with hyperbranched polymers confers them
superior comprehensive performance. However, it still remains a further
understanding of polymer crosslinking from the molecular chains to the
role of aggregates. In this study, three hyperbranched polysiloxane
structures (HBPSi-R) are synthesized as model macromolecules, each
featuring distinct terminal groups (R denotes amino, epoxy, and vinyl
groups) while similar molecular backbone (Si-O-C). These structures were
subsequently copolymerized with epoxy monomers to construct
interpenetrating HBPSi-R/epoxy/anhydride co-polymer systems. The spatial
molecular configuration and flexible Si-O-C branches of HBPSi-R endow
them with remarkable reinforcement and toughening effects. Notably, an
optimum impact strength of 28.9 kJ mol-1 is achieved with a mere 3%
loading of HBPSi-V, nearly three times that of the native epoxy (12.9 kJ
mol-1). By contrasting the terminal effects, the aggregation states and
crosslinking modes were proposed, thus clarifying the
supramolecular-dominant aggregation mechanism and covalent-dominant
dispersion mechanism, which influences the resulting material
properties. This work underscores the significance of aggregate science
in comprehending polymer crosslinking and provides theoretical insights
for tailoring material properties at a refined molecular level in the
field of polymer science.
Construction production trends and industry optimism in EU countries after the COVID-19 pandemic
Authors: Sylwia Szymanek
Published: June 2023

The purpose of this study is to present the current changing situation of construction markets in selected European countries. Current trends in construction production are presented in relation to changes resulting from the coronavirus pandemic and other factors using the examples of France, the Netherlands, Belgium, Austria, Germany, Spain and Poland. The EU Construction Confidence Index (CCI) and data on the number of building permits issued in selected countries were used for inference. Additional sources of knowledge were publicly available information on ongoing and planned campaigns and government actions affecting local construction markets. The analysis presented shows a clear impact of the pandemic on construction production trends, an increase in optimism in the industry at its extinction and renewed declines in optimism due to the increasing destabilisation of economies as a result of inflation, rising energy prices and the war in Ukraine. Despite the difficulties, construction markets are slowly regaining their pre-pandemic growths, although the aforementioned factors are slowing them down. Strong mature economies, supported by additional government funding, will recover much faster than developing countries where uncertainty is greater. The negative indicators for Poland forecast a slowdown and a longer period of return to pre-pandemic COVID-19 growth.
Assessment of genetic purity and earliness in F1 and F2 population of cucumber (Cucumis sativus L.) using SSR markers
Authors: Thakur Manisha , Kumar Ramesh , Sharma Parul , Sharma Rajnish
Published: June 2023

Simple Sequence Repeat (SSR) markers were used to assess the genetic purity
and earliness in F1 and F2 population of cucumber (Cucumis sativus L.)
respectively. Experiment was carried out at the Experimental Research Farm
of the Department of Vegetable Science, Dr Yashwant Singh Parmar University
of Horticulture and Forestry, Nauni, Solan, Himachal Pradesh (HP) during the
years 2015 and 2016. Experimental material used in the study comprised of
Khira-75, a commercial variety grown in low and mid hills of the state
(Himachal Pradesh) which is late in flowering and genotype PI-618860, an
inbred line collected from North Central Regional Plant Introduction
Station, USA which is early in flowering and tolerates various biotic
stresses. For assessment of genetic purity and earliness the parents
Khira-75 and PI-618860 were crossed and F1 and F2 population were raised.
Genetic purity studies revealed that one marker CSN 160 was observed to be
segregating in the parents as well as the population. Further, scoring of
earliness in F2 population revealed promising results using 2 co-dominant
SSR00262 and SSR17922 markers, which segregated in the parents and
population in correlation with the observed phenotypes.
Is there an advantage of monitoring via exosome-based detection of EGFR mutations during treatment in non-small cell lung cancer patients?
Authors: Karagur Ege , Demiray Aydin , Karagenc Nedim , Elver Esra , Tokgun Onur , Yaren Arzu , Dogu Gamze , Akca Hakan
Published: June 2023

We know that detection of EGFR mutations is very important for individual
therapy. Nowadays FFPE samples are commonly using to detect the EGFR
mutation status. But it has a few handicaps such as, tumor heterogeneity and
non-repeatable, it is need to examine mutation statues of EGFR after each
treatment regimen for individually treatment of NSCLC patients. Therefore,
there is still need to develop non-invasive and useable over and over again
approach for monitoring EGFR mutation statues and other genes for individual
therapy. So, we aim to examine whether exosomes are good target for
detection of EGFR mutation status or not. Pyrosequencing was used to detect,
EGFR mutation in FFPE and exosome samples in some NSCLC patients. For the
patients given different chemotherapy regime (n=28), PFS was evaluated
before and after treatment. In patients who were EGFR positive before
treatment, the median PFS for EGFR mutation-positive patients after
treatment was 101.7 weeks (95% CI: 0.09-3.21), while for patients who were
negative after treatment, the median PFS was 42.43 weeks (95% CI: 0.31-
10.52). Likewise, in patients who were EGFR negative before treatment and
EGFR mutation negative after treatment, the PFS was median 52 weeks (95% CI:
0.17-2.84), while in patients who were positive after treatment, the median
PFS was 27.57 weeks (95% CI: 0.35-5.58). We show that exosomes are good
tools for monitoring EGFR mutation status and exosomes can be use as
semi-invasive method for isolation of tumor DNAs for detection of mutation
statues for individually treatment of NSCLC patients.
Genetic variability for plant growth, fruit, seed and biochemical traits in bell pepper breeding populations under North Indian plains
Authors: Rani Menisha , Jindal Salesh , Meena Om
Published: June 2023

The present research aimed to estimate the plant growth, fruit yield, seed
and biochemical traits among the seven pepper parental lines and their six
BC2F1 populations in order to generate information regarding the extent of
genetic variability, heritability and genetic advance. The study was
conducted using a randomized complete block design (RCBD) with three
replications at the Vegetable Research Farm of Punjab Agricultural
University, Ludhiana, India. The analysis of variance (ANOVA) showed
significant mean squares due to parents and BC2F1 populations for almost all
the studied traits, it indicating the presence of a sufficient amount of
inherent variability among the parental line and developed populations which
could be exploited via selection. The plant height, fruit weight, fruit
width, number of lobes fruit-1, chlorophyll b, total chlorophyll,
chlorophyll a and total fruit yield plant-1 were recorded high GCV and PCV
among the parental lines and developed populations BC2F1, indicating higher
extent of variability for these traits in the evaluated genotypes. The
results revealed that traits with high GCV and PCV offer a better scope for
improvement through simple selection. High heritability and high estimates
of genetic advance were determined for the traits viz., plant height, fruit
weight, ascorbic acid content and total fruit yield plant-1, in both parents
and populations. Based on these results, we can conclude that these traits
are under the additive gene effects and that above mentioned characters
could be considered as a good selection indices in bell pepper.
AMMI analysis for grain yield in bread wheat recombinant inbred lines
Authors: Muhammad Sajid , Jadoon Sultan , Mohammad Fida , Khalil Hussain , Ahmad Sheraz , Khan Ullah
Published: June 2023

Identification of high yielding relatively stable genotypes is an integral
objective of plant breeding programs. Testing of genotypes across
environments is required to determine yield stability of genotypes. The
specific objective of the current study was to analyze genotype by
environment interaction (GEI) for grain yield of 44 bread wheat recombinant
inbred lines (RILs) and six check cultivars using additive main effect and
multiplicative interaction (AMMI) model. Experiments were planted using
alpha lattice design with two replicates in Peshawar (E-1 and E-3), Hangu
(E-2 and E-4) and Kohat (E-5) Khyber Pakhtunkhwa province, Pakistan.
Analysis of variance revealed significant differences among RILs for all
traits while interactions due to genotype by environment were significant
for all traits except days to emergence and 1000-grain weight. Significant
GEI justified environment-specific as well as AMMI analysis to identify RILs
with specific and wider adaptation. The AMMI analysis revealed that the
first interaction principal component analysis (IPCA 1) captured 64% of GEI
sum of squares while the second interaction principal component analysis
(IPCA 2) explained 25.8% of the interaction sum of square. The AMMI biplot
identified G30 as high yielding genotype followed by G19 and G49, whereas
low yielding RILs were G13, G8 and G7. Similarly G30, being close to IPCA1
axis, was the most stable RIL with wider adaptability followed by G31 and
G25. Based on AMMI stability value (ASV), RILs G18 (2.15), G5 (2.78), G27
(3.72), G44 (4.31), G25 (4.43), G42 (4.57), G43 (5.78), G11 (5.82), G1
(7.66) and G29 (7.81) were recognized in the given order of relative
stability. Stability analysis identified G49 (Wafaq ? Ghaznavi-98-3) as high
yielding stable genotype among RILs which can be commercialized after
fulfilling procedural requirements.
Characterization of Pseudomonas syringae pv. morsprunorum originating from sweet cherry and plum in Serbia
Authors: Ilicic Renata , Jelusic Aleksandra , Blagojevic Milan , Bagi Ferenc , Vrandecic Karolina , Stankovic Slavisa , Popovic-Milovanovic Tatjana
Published: June 2023

Pseudomonas strains originating from symptomatic (bacterial spot) leaf
tissues of sweet cherry (Topola, Sumadija) and plum (Krusedol Selo, Srem)
were isolated during 2016 and 2020, respectively. Based on the findings
yielded by classical microbiological methods, LOPAT (+---+), GATTa (--++)
and pathogenicity tests performed on detached fruitlets (sweet and sour
cherry) and pods (bean pods), all strains were confirmed to belong to P.
syringae pv. morsprunorum. The detection of cfl gene allowed strains that
belong to race 1 to be identified. The DNA fingerprinting patterns obtained
with four rep-PCR (BOX and ERIC), RAPD-PCR (M13), and IS50-PCR (IS50)
methods revealed that the seven tested sweet cherry and plum P. s. pv.
morsprunorum strains, as well as comparative KBNS71 and the reference strain
CFBP 2119, were genetically heterogeneous. Conversely, MLSA based on the
four-gene-based scheme (gapA, gltA, gyrB, and rpoD) indicated genetic
homogeneity among all tested Serbian sweet cherry and plum strains, as well
as P. s. pv. morsprunorum race 1 strains from the NCBI. Although the MLSA
findings indicate that the sweet cherry and plum strains used in this study
are 100% identical, as they might have different virulence genes, genome
sequencing should be performed to eventually find the strain sub-clades
based on the host.