bluuebunny/crossref_metadata_2025 huggingface dataset:
IgaA Protein, GumB, Has a Global Impact on the Transcriptome and Surface Proteome of Serratia marcescens
Authors: Stella Nicholas A. , Romanowski Eric G. , Brothers Kimberly M. , Calvario Rachel C. , Shanks Robert M. Q.
Published: November 2022

Bacterial stress response signaling systems, like the Rcs system are triggered by membrane and cell wall damaging compounds, including antibiotics and immune system factors. These regulatory systems help bacteria survive envelope stress by altering the transcriptome resulting in protective phenotypic changes that may also influence the virulence of the bacterium.
Whole-Genome Sequence of a Clinical Enterococcus gallinarum Strain in a Positive Hemoculture from Siriraj Hospital, Thailand
Authors: Yaikhan Thunchanok , Kampakdee Iyarace , Jenjaroenpun Piroon , Thaipisuttikul Iyarit , Wongsurawat Thidathip , Kamolvit Witchuda
Published: November 2022

Enterococcus gallinarum
is a rare causative agent of hospital-acquired bacteremia. Here, we reported the complete genome of
E. gallinarum
strain WKB01, which was directly isolated from a positive hemoculture in Siriraj Hospital, Thailand. Comprehensive analysis demonstrated the clinically relevant
tetM
gene presenting in its genome.
Transcriptomic-Guided Phosphonate Utilization Analysis Unveils Evidence of Clathrin-Mediated Endocytosis and Phospholipid Synthesis in the Model Diatom,
Phaeodactylum tricornutum
Authors: Shu Huilin , You Yanchun , Wang Hongwei , Wang Jingtian , Li Ling , Ma Jian , Lin Xin
Published: November 2022

Phosphonates contribute ~25% of total dissolved organic phosphorus in the ocean, and are found to be important for marine phosphorus biogeochemical cycle. As a type of biogenic phosphonate produced by microorganisms, 2-aminoethylphosphonic acid (2-AEP) widely exists in the ocean.
Multiomics Characterization of the Canada Goose Fecal Microbiome Reveals Selective Efficacy of Simulated Metagenomes
Authors: Gil Joshua C. , Hird Sarah M.
Published: November 2022

The taxonomic composition of a microbiome is predominately identified using amplicon sequencing of 16S rRNA genes, but as a single marker, it cannot identify functions (genes). Metagenome and metatranscriptome sequencing can determine microbiome function but can be cost prohibitive.
Paleozoic evolution of the northern Laurentian margin: Evaluating links between the Caledonian, Ellesmerian, and Cordilleran orogens
Authors: McClelland* William C. , Strauss* Justin V. , Gilotti* Jane A. , Colpron* Maurice
Published: November 2022

The passive margins of Laurentia that formed during Neoproterozoic–Cambrian breakup of the supercontinent Rodinia record subsequent histories of contraction and translation. This contribution focuses on the northern margin of Laurentia, where recent geologic and geochronologic data have provided new insight into the evolution of northern North America. The Laurentian margin in East and North-East Greenland records synorogenic sedimentation and deformation associated with the Caledonian orogeny—the Silurian to Devonian continent-continent collision between Baltica and Laurentia that followed closure of the northern tract of the Iapetus Ocean. The timing of ultrahigh-pressure metamorphism and simultaneous sinistral and dextral strike-slip faulting in North-East Greenland indicates that the Himalayan-style orogen persisted through the Devonian. In contrast, the Franklinian margin further west records sinistral strike-slip translation of allochthonous crustal blocks and arc fragments starting in the Ordovician–Silurian and culminating with the Devonian–Carboniferous Ellesmerian orogeny, the origin of which remains enigmatic. We suggest that Ellesmerian deformation was related to widespread transpression associated with northward motion of Laurentia during Acadian and Neo-Acadian deformation along the Appalachian margin rather than orthogonal ocean basin closure and microcontinent-continent collision. The Pearya terrane and North Slope subterrane of the Arctic Alaska terrane, separated from the Franklinian passive margin by the Petersen Bay fault and Porcupine shear zone, respectively, best preserve the Paleozoic translational and transpressional history of the northern Laurentian margin. These two major structures record a complex history of terrane accretion and translation that defines the Canadian Arctic transform system, which truncated the Caledonian suture to the east and ultimately propagated early Paleozoic subduction to the Cordilleran margin of western Laurentia.
Supplemental Material: Pre-agricultural soil erosion rates in the midwestern United States
Authors: Quarrier Caroline L. , Larsen Isaac J. , al. et
Published: November 2022

Methodological details, supplemental figures, and Tables S1–S9.  
Supplemental Material: High-magnesium igneous associations record final-stage geodynamic process of the southeastern segment of the Central Asian Orogenic Belt
Authors: Jing Yan , Ge Wen-chun , al. et
Published: November 2022

Text: Methods. Figure S1: Diagrams showing chondrite-normalized REEs patterns for zircons from the high-Mg igneous associations in the Qinghe region. Figure S2: Diagrams showing variation of selected elements vs. LOI to check for element mobility during post-magmatic alteration. Figure S3: (A) SiO2 vs. Th/La and (B) MgO vs. Nb/La diagrams of the high-Mg igneous rocks in the Qinghe region. Figure S4: (A) MgO vs. CaO; (B) MgO vs. Cr; (C) MgO vs. Ni; (D) MgO vs. TiO2; (E) Sr vs. Ba; and (F) TiO2 versus V diagrams of the high-Mg igneous rocks in the Qinghe region. Mineral abbreviations: Ol—olivine; Hbl—hornblende; Cpx—clinopyroxene; Pl—plagioclase; Kf—potassium feldspar; Bi—biotite. Figure S5: Diagrams of (A) Nb/Yb vs. Th/Yb; (B) Th/Yb vs. La/Yb of the high-Mg igneous rocks in the Qinghe region. Tables S1–S5.
Supplemental Material: Petrogenesis and tectonic setting of Neoarchean tonalitic-trondhjemitic-granodioritic gneisses in the Xiwulanbulang area of the Yinshan block, North China craton
Authors: Wang Xiao , Zhang Jian , et al.
Published: November 2022

Table S1: U-Pb dating results for zircons from the Xiwulanbulang tonalitic-trondhjemitic-granodioritic gneisses in the Yinshan block. Table S2: Major-element (wt%) and trace-element (ppm) compositions of the Xiwulanbulang TTG gneisses in the Yinshan block. Table S3: Zircon Hf isotopic data for the Xiwulanbulang TTG gneisses in the Yinshan block. Table S4: Whole-rock Sr-Nd isotopic compositions of the Xiwulanbulang TTG gneisses in the Yinshan block. Table S5: Whole-rock Pb isotopic compositions of the Xiwulanbulang TTG gneisses in the Yinshan block.
Supplemental Material: A possible sea-level fall trigger for the youngest rejuvenated volcanism in Hawaiʻi
Authors: Jicha Brian R. , al. et
Published: November 2022

Table S1: Complete 40Ar/39Ar data. Table S2: Fo (=Mg/[Mg+Fe]) and Ni EPMA data for olivine profiles from the Koko Rift (Koko Crater bomb and flow, Kaupo lava flow and Kāohikaipu Island) from core to rim.
Supplemental Material: Stratigraphy of the Cretaceous/Paleogene (K/Pg) boundary at the Global Stratotype Section and Point (GSSP) in El Kef, Tunisia: New insights from the El Kef Coring Project
Authors: Jones Heather L. , al. et
Published: November 2022

Six supporting figures, two supporting tables, and two data repository files.
Rare extension of pancreatic pseudocyst withMycobacterium abscessusinto the iliopsoas muscle
Authors: Mark Justin David , Park Travis , Velez Quinones Virginia , Isaac Shaun
Published: November 2022

Pancreatic pseudocyst is a well-known complication of both acute and chronic pancreatitis. Although extension into other anatomical sites is common, extension into the retrofascial space causing an iliopsoas abscess is exceedingly rare. Although its low incidence creates a diagnostic challenge for clinicians, early diagnosis is essential to prevent significant complications and poor patient outcomes. We present a case of iliopsoas abscess with unusual culture fluid growth in the setting of acute on chronic pancreatitis secondary to extension of a pancreatic pseudocyst. We also offer a brief review of the literature and pathophysiology of the condition.
Risk factors for community-acquired bacterial infection among young infants in South Asia: a longitudinal cohort study with nested case–control analysis
Authors: Connor Nicholas E , Islam Mohammad Shahidul , Mullany Luke C , Shang Nong , Bhutta Zulfiqar A , Zaidi Anita K M , Soofi Sajid , Nisar Imran , Panigrahi Pinaki , Panigrahi Kalpana , Satpathy Radhanath , Bose Anuradha , Isaac Rita , Baqui Abdullah H , Mitra Dipak K , Sadeq-ur Rahman Qazi , Hossain Tanvir , Schrag Stephanie J , Winchell Jonas M , Arvay Melissa L , Diaz Maureen H , Waller Jessica L , Weber Martin W , Hamer Davidson H , Hibberd Patricia , Nawshad Uddin Ahmed A S M , Islam Maksuda , Hossain Mohammad Belal , Qazi Shamim A , El Arifeen Shams , Darmstadt Gary L , Saha Samir K
Published: November 2022

Objective

Risk factors predisposing infants to community-acquired bacterial infections during the first 2 months of life are poorly understood in South Asia. Identifying risk factors for infection could lead to improved preventive measures and antibiotic stewardship.

Methods

Five sites in Bangladesh, India and Pakistan enrolled mother–child pairs via population-based pregnancy surveillance by community health workers. Medical, sociodemographic and epidemiological risk factor data were collected. Young infants aged 0–59 days with signs of possible serious bacterial infection (pSBI) and age-matched controls provided blood and respiratory specimens that were analysed by blood culture and real-time PCR. These tests were used to build a Bayesian partial latent class model (PLCM) capable of attributing the probable cause of each infant’s infection in the ANISA study. The collected risk factors from all mother–child pairs were classified and analysed against the PLCM using bivariate and stepwise logistic multivariable regression modelling to determine risk factors of probable bacterial infection.

Results

Among 63 114 infants born, 14 655 were assessed and 6022 had signs of pSBI; of these, 81% (4859) provided blood samples for culture, 71% (4216) provided blood samples for quantitative PCR (qPCR) and 86% (5209) provided respiratory qPCR samples. Risk factors associated with bacterial-attributed infections included: low (relative risk (RR) 1.73, 95% credible interval (CrI) 1.42 to 2.11) and very low birth weight (RR 5.77, 95% CrI 3.73 to 8.94), male sex (RR 1.27, 95% CrI 1.07 to 1.52), breathing problems at birth (RR 2.50, 95% CrI 1.96 to 3.18), premature rupture of membranes (PROMs) (RR 1.27, 95% CrI 1.03 to 1.58) and being in the lowest three socioeconomic status quintiles (first RR 1.52, 95% CrI 1.07 to 2.16; second RR 1.41, 95% CrI 1.00 to 1.97; third RR 1.42, 95% CrI 1.01 to 1.99).

Conclusion

Distinct risk factors: birth weight, male sex, breathing problems at birth and PROM were significantly associated with the development of bacterial sepsis across South Asian community settings, supporting refined clinical discernment and targeted use of antimicrobials.
The social dimensions of community delivery of intermittent preventive treatment of malaria in pregnancy in Madagascar, Mozambique, Nigeria and the Democratic Republic of the Congo
Authors: Alonso Yara , Lusengi Wade , Manun’Ebo Manu F , Rasoamananjaranahary Aimée M , Rivontsoa Noroharifetra Madison , Mucavele Estêvão , Torres Neusa , Sacoor Charfudin , Okebalama Hope , Agbor Ugo James , Nwankwo Ogonna , Meremikwu Martin , Roman Elaine , Pagnoni Franco , Menéndez Clara , Munguambe Khátia , Enguita-Fernàndez Cristina
Published: November 2022

Introduction

Intermittent preventive treatment in pregnancy with sulphadoxine pyrimethamine (IPTp) is a key malaria prevention strategy in sub-Saharan African countries. We conducted an anthropological study as part of a project aiming to evaluate a community-based approach to the delivery of IPTp (C-IPTp) through community health workers (CHWs) in four countries (the Democratic Republic of Congo, Madagascar, Mozambique and Nigeria), to understand the social context in order to identify key factors that could influence C-IPTp acceptability.

Methods

A total of 796 in-depth interviews and 265 focus group discussions were undertaken between 2018 and 2021 in the four countries with pregnant women, women of reproductive age, traditional and facility-based healthcare providers, community leaders, and relatives of pregnant women. These were combined with direct observations (388) including both community-based and facility-based IPTp delivery. Grounded theory guided the overall study design and data collection, and data were analysed following a combination of content and thematic analysis.

Results

A series of key factors were found to influence acceptability, delivery and uptake of C-IPTp in project countries. Cross-cutting findings include the alignment of the strategy with existing social norms surrounding pregnancy and maternal health-seeking practices, the active involvement of influential and trusted actors in implementation activities, existing and sustained trust in CHWs, the influence of husbands and other relatives in pregnant women’s care-seeking decision-making, the working conditions of CHWs, pregnant women’s perceptions of SP for IPTp and persistent barriers to facility-based antenatal care access.

Conclusions

The findings provide evidence on the reported acceptability of C-IPTp among a wide range of actors, as well as the barriers and facilitators for delivery and uptake of the intervention. Overall, C-IPTp was accepted by the targeted communities, supporting the public health value of community-based interventions, although the barriers identified should be examined if large-scale implementation of the intervention is considered.
High precision but systematic offset in a standing bioelectrical impedance analysis (BIA) compared with dual-energy X-ray absorptiometry (DXA)
Authors: Potter Adam W , Nindl Lyndsey J , Soto Lara D , Pazmino Angie , Looney David P , Tharion William J , Robinson-Espinosa Jasmine A , Friedl Karl E
Published: November 2022

Bioelectrical impedance analysis (BIA) provides a practical method of body composition estimation for field research and weight management programmes, with devices and algorithms that have improved in recent years. We compared suitability of a commercial BIA system that uses multi-frequency-based proprietary algorithms (InBody 770, Cerritos, California, USA) and a laboratory-based validated single-frequency system (Quantum IV, RJL Systems, Clinton Township, Michigan, USA) with dual-energy X-ray absorptiometry (DXA) (iDXA, GE Lunar, Madison, Wisconsin, USA). Volunteers included fit non-obese active duty US Marines (480 men; 315 women), assessed by DXA and the two BIA systems. Both RJL and InBody BIA devices predicted DXA-based fat-free mass (FFM) (mean absolute error (MAE) 2.8 and 3.1 kg, respectively) and per cent body fat (%BF) (MAE 3.4% and 3.9%, respectively), with higher correlations from the InBody device (r2=0.96 (%BF) and 0.84 (FFM)) versus the RJL (r2=0.92 (%BF) and 0.72 (FFM)). InBody overpredicted FFM (bias +2.7, MAE 3.1 kg) and underpredicted %BF (bias −3.4 and MAE 3.9%) versus the RJL. A 3% correction factor applied to the InBody device results provided values very close to the DXA measurements. These findings support the application of modern BIA systems to body composition goals of maximum %BF and minimum lean body mass for both men and women.
Improving psychosocial distress for young adolescents in rural schools of Pakistan: study protocol of a cluster randomised controlled trial
Authors: Hamdani Syed Usman , Huma Zill-E- , Malik Aiysha , Nizami Asad Tamizuddin- , Baneen Um ul , Suleman Nadia , Javed Hashim , Wang Duolao , van Ommeren Mark , Mazhar Samra , Khan Shahzad Alam , Minhas Fareed Aslam , Rahman Atif
Published: November 2022

Introduction

Emotional problems are leading contributors to health burden among adolescents worldwide. There is an urgent need for evidence-based psychological interventions for young people. This study aims to evaluate the effectiveness of a school-based, group psychological intervention, Early Adolescent Skills for Emotions (EASE) developed by the WHO to improve psychosocial distress in Pakistani adolescents.

Method and analysis

A two-arm, single-blinded, cluster randomised controlled trial, with a wait-list control arm is being conducted in school settings of rural Pakistan. Forty eligible public-school clusters have been randomised (stratified by gender) on a 1:1 allocation ratio into intervention (n=20) and control arm (n=20). Following informed consent, 564 adolescents with psychosocial distress (Youth-reported Paediatric Symptoms Checklist, cut-off ≥28) from 40 schools have been enrolled into the trial (14±3 average cluster size) between 2 November 2021 and 30th November 2021. Participants in the intervention arm will receive EASE in 7-weekly adolescents and 3-biweekly caregivers group sessions in schools. The adolescent sessions involve the components of psychoeducation, stress management, behavioural activation, problem-solving and relapse prevention. Caregivers will receive training to learn and implement active listening; spending quality time and using praise as a strategy to help their children. The primary outcome is reduction in psychosocial distress at 3 months postintervention. Secondary outcomes include symptoms of depression and anxiety, caregiver–adolescent relationship and caregivers’ well-being. Outcomes will be assessed at baseline, immediate 1 week and 3-months postintervention. Qualitative process evaluation will explore barriers and facilitators to programme implementation in low-resource school settings.

Ethics

Ethics approval has been obtained from Central Ethics Committee of University of Liverpool, UK, Ethics Review Committee of WHO Geneva and from the Institutional Review Board of Human Development Research Foundation (HDRF), Pakistan.

Dissemination

The findings of the study will be disseminated by WHO and through peer-reviewed publications.

Trial registration number

ISRCTN17755448.
Association of urinary bisphenol A concentrations with in vitro fertilisation outcomes: a systematic review and meta-analysis protocol
Authors: Cao Xian-Ling , Xu Nai-Xin , Zhou Xuan-You , Xu Chen-Ming
Published: November 2022

Introduction

Bisphenol A (BPA) is a common environmental endocrine disruptor. BPA has been reported to be associated with female infertility, which may not only affect natural pregnancy and natural fertility but also affect the outcomes of in vitro fertilisation (IVF). BPA exposure may help to partly explain the unsatisfactory IVF outcomes, but the relationship between the concentrations of BPA in urine and IVF outcomes remains controversial. Therefore, we will perform a meta-analysis to identify and review the relationship between urinary BPA concentrations and IVF outcomes.

Methods and analysis

A comprehensive literature search will be performed in PubMed, Web of Science and the Cochrane central register of controlled trials for relevant articles using MeSH terms and related entry terms (up to 20 April 2022). The language will be restricted to English. Articles will be screened for inclusion in or exclusion from the study independently by two reviewers after removing the duplicates. The titles and abstracts followed by full-text screening will also be conducted independently by two reviewers. In addition, the references of the included literature will also be traced to supplement our search results and to obtain all relevant literature. The Newcastle-Ottawa Scale will be used to assess the methodological quality of the included studies using a star rating system ranging from 0 to 9 stars. Heterogeneity in estimates from different articles will be quantified, and publication bias will be investigated using funnel plots. Finally, a sensitivity analysis will also be conducted to estimate whether our results could have been markedly affected by a single included study.

Ethics and dissemination

Ethical approval is not required for this protocol, as participants are not included. Findings will be disseminated through peer-reviewed publications and conference presentations.
Digitally distributed Yoga Intervention in Breast Cancer Rehabilitation (DigiYoga CaRe): protocol for a randomised controlled trial
Authors: Ohlsson Nevo Emma , Arvidsson-Lindvall MiaLinn , Hellerstedt Börjeson Susanne , Hagberg Lars , Hultgren Hörnqvist Elisabeth , Valachis Antonios , Wickberg Åsa , Duberg Anna
Published: November 2022

Introduction

Breast cancer is the most prevalent cancer among women. The treatment is extensive; in addition to surgery, various combinations of radiation therapy, chemotherapy and antibody and endocrine treatment can be applied. Cancer-related fatigue (CRF) is high in patients with breast cancer, peaking during chemotherapy, but may persist for several years. Physical activity has proven to be effective in reducing CRF in breast cancer rehabilitation, but many patients tend to be less active after the diagnosis. Yoga has a previously demonstrated effect on energy levels and digitally distributed yoga intervention can potentially increase accessibility in pandemic times and facilitate participation for patients susceptible to infection and those living far from organised rehabilitation opportunities. The purpose of this study, Digital Yoga Intervention in Cancer Rehabilitation (DigiYoga CaRe) is to investigate whether a 12-week digitally distributed yoga intervention can reduce CRF and stress, improve health-related quality of life (HRQL) and affect pro-inflammatory and metabolic markers in patients with breast cancer.

Methods and analysis

This multicentre study will adopt a randomised controlled design including 240 persons after their breast cancer surgery. They will be randomised to a 12-week digitally distributed yoga intervention or to a control group. The intervention group practice yoga two times a week, one yoga class live-streamed to the patient’s computer or mobile device and one prerecorded video class for self-training. The controls receive standardised care, gift cards for flowers and access to yoga video links after the data collection has ended. The primary analysis will be performed following the principle of intention to treat. Data will be collected by questionnaires, blood samples, accelerometers and interviews.

Ethics and dissemination

The DigiYoga CaRe study was approved by the Regional Ethical Review Board in Lund. The final results of this study will be disseminated to conference, patient and public involvements and peer-reviewed publications.

Trial registration number

NCT04812652.
Pretending to care
Authors: Hardman Doug
Published: November 2022

On one hand, it is commonly accepted that clinicians should not deceive their patients, yet on the other there are many instances in which deception could be in a patient’s best interest. In this paper, I propose that this conflict is in part driven by a narrow conception of deception as contingent on belief. I argue that we cannot equate non-deceptive care solely with introducing or sustaining a patient’s true belief about their condition or treatment, because there are many instances of clinical care which are non-doxastic and non-deceptive. Inasmuch as this is true, better understanding of non-doxastic attitudes, such as hope and pretence, could improve our understanding of deception in clinical practice.
Verification and trust in healthcare
Authors: Jesudason Edwin
Published: November 2022

‘Trust but verify’ is a translation of a Russian proverb made famous by former US President Ronald Reagan. In their paper, Grahamet alappear to take an alternate view that might be summarised astrust or verify. The contrast highlights a general question: how do we come to trust in authorities? More specifically, Grahamet alclaim: (1) that UK Trusted Research Environments (TREs) are misnamed as future custodians for big health data because their promised verification systems actually negate the uncertainty that trust requires; (2) the public is mistaken if it believes such verification enhances trust; (3) the notion of building public trust in TREs is unclear or misconceived. In response, I propose a more relational, perhaps less reductionist account. I argue (1) that verification is itself a source of uncertainty, so it can’t extinguish the uncertainty needed for trust; (2) it’s nevertheless possible for verification to enhance feelings of trust thereby reducing our needs for the same; (3) trust is also social, even political, meaning institutions like TREs may become too big to fail—and end up shielding their ‘trusted’ brand by being less candid about inevitable flaws in their verification systems.
Thrombus migration in ischemic stroke due to large vessel occlusion: a question of time
Authors: Riegler Christoph , Siebert Eberhard , Kleine Justus F , Nolte Christian H
Published: November 2022

Background

Thrombus migration (TM) is frequently observed in large vessel occlusion (LVO) ischemic stroke to be treated by endovascular thrombectomy (EVT). TM may impede complete recanalization and hereby worsen clinical outcomes. This study aimed to delineate factors associated with TM and clarify its impact on technical and functional outcome.

Methods

All patients undergoing EVT due to LVO in the anterior circulation at two tertiary stroke centers between October 2015 and December 2020 were included. Source imaging data of all individuals were assessed regarding occurrence of TM by raters blinded to clinical data. Patient data were gathered as part of the German Stroke Registry, a multicenter, prospective registry assessing real-world outcomes. Technical outcome was assessed by modified Thrombolysis in Cerebral Infarction scale (mTICI). Functional outcome was assessed by modified Rankin Scale (mRS) at 3 months.

Results

The study consisted of 512 individuals, of which 71 (13.8%) displayed TM. In adjusted analyses, TM was associated with longer time from primary imaging to reassessment in the angio suite (aOR 2.37 (1.47 to 3.84) per logarithmic step) and intravenous thrombolysis (IVT; aOR 4.07 (2.17 to 7.65)). In individuals with IVT, a needle-to-groin time >1 hour was associated with higher odds for TM (aOR 2.60 (1.20 to 5.99)). TM was associated with lack of complete recanalization (aORmTICI30.46 (0.24 to 0.90)) but TM did not worsen odds for good clinical outcome (aORmRS≤2_d900.89 (0.47 to 1.68)).

Conclusions

TM is associated with IVT and longer time between sequential assessments of thrombus location. Consequently, TM may be of high relevance in patients with drip-and-ship treatment.
The invariant action for solitonic 5-branes
Authors: Molina Jeffrey , Musaev Edvard
Published: November 2022

We construct the full effective action including DBI and WZ terms for solitonic 5-branes covariant under T-duality. The result is a completion of results known in the literature to a full T-duality covariant expression. The covariant WZ action includes previously omitted R–R terms. The obtained full covariant effective action reproduces the one obtained by S-duality from the D5-brane upon the correct choice of the covariant charge.
Higgs boson decays $$h\rightarrow Z \gamma $$ and $$h\rightarrow m_V Z$$ in the $$U(1)_X$$SSM
Authors: Wang Xi , Zhao Shu-Min , Wang Tong-Tong , Su Lu-Hao , Li Wei , Zhang Ze-Ning , Yang Zhong-Jun , Feng Tai-Fu
Published: November 2022

We present a detailed analysis of the Higgs boson decays $$h\rightarrow Z \gamma $$

h
→
Z
γ

and $$h\rightarrow m_V Z$$

h
→

m
V

Z

in the $$U(1)_X$$

U

(
1
)

X

SSM, with $$m_V$$

m
V

denoting one of the mesons ($$\omega ,\rho ,\phi ,J/{\psi },\Upsilon $$

ω
,
ρ
,
ϕ
,
J
/
ψ
,
Υ

). Using the effective Lagrangian method, we calculate the effective constants $$C_{\gamma Z}$$

C

γ
Z

(CP-even) and $${\tilde{C}}_{\gamma Z}$$

C
~

γ
Z

(CP-odd) for the vertex $$h \gamma Z$$

h
γ
Z

, which are corrected by the new particle loop diagrams. Numerically, the ratio $${\Gamma }_{U(1)_X}(h\rightarrow Z \gamma )/{\Gamma }_{SM}(h\rightarrow Z \gamma )$$

Γ

U

(
1
)

X

(
h
→
Z
γ
)

/

Γ

SM

(
h
→
Z
γ
)

is between 1.02 and 1.35. For the vector mesons $$\omega ,\rho ,\phi $$

ω
,
ρ
,
ϕ

and $$J/{\psi }$$

J
/
ψ

, the ratios $${\Gamma }_{U(1)_X}(h\rightarrow m_V Z )/{\Gamma }_{SM}(h\rightarrow m_V Z)$$

Γ

U

(
1
)

X

(
h
→

m
V

Z
)

/

Γ

SM

(
h
→

m
V

Z
)

are mainly distributed in the range of (1.01–1.45). When $$m_V$$

m
V

represents $$\Upsilon $$
Υ
, the ratio $${\Gamma }_{U(1)_X}(h\rightarrow \Upsilon Z )/{\Gamma }_{SM}(h\rightarrow \Upsilon Z)$$

Γ

U

(
1
)

X

(
h
→
Υ
Z
)

/

Γ

SM

(
h
→
Υ
Z
)

is mostly located in the range of (1.002–1.30). The aim of this work is to provide a reference for probing the $$U(1)_X$$

U

(
1
)

X

SSM model via the Higgs decays $$h\rightarrow Z \gamma $$

h
→
Z
γ

and $$h\rightarrow m_V Z$$

h
→

m
V

Z

.
Design Implications for One-Way Text Messaging Services that Support Psychological Wellbeing
Authors: Bhattacharjee Ananya , Pang Jiyau , Liu Angelina , Mariakakis Alex , Williams Joseph Jay
Published: November 2022

One-way text messaging services have the potential to support psychological wellbeing at scale without conversational partners. However, there is limited understanding of what challenges are faced in mapping interactions typically done face-to-face or via online interactive resources into a text messaging medium. To explore this design space, we developed seven text messages inspired by cognitive behavioral therapy. We then conducted an open-ended survey with 788 undergraduate students and follow-up interviews with students and clinical psychologists to understand how people perceived these messages and the factors they anticipated would drive their engagement. We leveraged those insights to revise our messages, after which we deployed our messages via a technology probe to 11 students for two weeks. Through our mixed-methods approach, we highlight challenges and opportunities for future text messaging services, such as the importance of concrete suggestions and flexible pre-scheduled message timing.
A Neoteric Approach for Logic with Embedded Memory Leveraging Crosstalk Computing
Authors: Samant Prerana , Macha Naveen Kumar , Rahman Mostafizur
Published: November 2022

One of the essential elements of computing is the memory element. Flip-flops form an integral part of a System-on-Chip (SoC) and consume most of the area on the die. To meet the high-speed performance demands by the data-intensive applications such as artificial intelligence, cloud computing, and machine learning, we propose to integrate memory with the logic to get built-in memory Logic circuits that operate based on the crosstalk computing logic. These circuits are called
Crosstalk Built-in Memory Logic (CBML)
circuits, which exploit the detrimental interconnect crosstalk and astutely turn this unwanted effect into a computing principle with embedded memory. By virtue of our novel CBML circuit technique, the logic is computed, and the result is stored intrinsically within these complex circuits. The stored values will be retained irrespective of the change in input until the next logic evaluation cycle. This neoteric embedding of memory in logic provides high-speed operation with a reduced number of transistors. In this article, we have manifested the built-in memory feature of the complex CBML circuits using 16 nanometer (nm) PTM models in HSPICE. Benchmarking is performed by comparing with the equivalent static CMOS circuits to compare the number of transistors, power, and performance. It is observed that the number of transistors consumed by CBML 4-bit Full-Adder (the key element prevalent in Arithmetic circuits, e.g., ALU, Counters) is up to 46% less, and performance is improved by 27% over the equivalent CMOS circuits. This circuit serves as an example of a large-scale CBML circuit. Also, the performance improvement achieved by other circuits such as 3-input AND and the CARRY logic is up to 60% along with a 40% reduction in the number of transistors. CBML circuits have the potential to pave the way for special high-speed macros with specifically engineered structures.
A Survey of Alternative Measures of Macroeconomic Uncertainty: Which Measures Forecast Real Variables and Explain Fluctuations in Asset Volatilities Better?
Authors: David Alexander , Veronesi Pietro
Published: November 2022

In the past 20 years, measures of economic uncertainty have been developed that are purely market price based; structural model based, using data on real fundamentals and asset prices; text based; or survey based. We compare the performance of these uncertainty measures in forecasting three real variables with irreversibilities—investment, hiring, and credit creation—as well as in explaining fluctuations in stock market and Treasury bond market volatility. In general, we find that structural model–based measures do better than measures constructed using other approaches, with a model of stock market volatility by David and Veronesi performing the best on several (but not all) dimensions. Their learning-based model's volatility places time-varying weights on inflation, earnings, and consumption news, as agents in the economy assess the impact that inflation has on the stability of real economic growth.
Player Tracking Data in Sports
Authors: Kovalchik Stephanie A.
Published: November 2022

There has been rapid growth in the collection of player tracking data in recent years. These data, providing spatiotemporal locations of players and ball at high resolution, have spurred methodological developments in a range of sports. There have been impacts in the development of player performance measurement (e.g., distance traveled) and in the attribution of value to specific plays (e.g., expected points from a given position) or even specific actions within a play. This review highlights key methodological contributions via statistical and machine learning approaches. The studies and outcomes discussed show how sports can be a playground for extending analytical techniques in a range of areas. The review also describes the ongoing methodological challenges associated with the use of tracking data.
Electrochemical and Degradation Studies on One-Dimensional Tunneled Sodium Zirconogallate (NZGO) + Yttria-Stabilized Zirconia (YSZ) Composite, Mixed Sodium and Oxygen Ion Conductor
Authors: Elahi Pooya , Horsley Jude , Sparks Taylor D.
Published: November 2022

In recent years, multi-phase materials capable of multi-ion transport have emerged as attractive candidates for a variety of electrochemical devices. Here, we provide experimental results for fabricating a composite electrolyte made up of a one-dimensional fast sodium-ion conductor, sodium zirconogallate, and an oxygen-ion conductor, yttria-stabilized zirconia. The composite is synthesized through a vapor phase conversion mechanism, and the kinetics of this process are discussed in detail. The samples are characterized using diffraction, electron microscopy, and electrochemical impedance spectroscopy techniques. Samples with a finer grain structure exhibit higher kinetic rates due to larger three-phase boundaries (TPBs) per unit area. The total conductivity is fitted to an Arrhenius type equation with activation energies ranging from

0.23

eV

at temperatures below

550

°
C

to

1.07

eV

above

550

°
C
.

The electrochemical performance of multi-phase multi-species, mixed

Na

+

and

O

2
−

conductor, is tested under both oxygen chemical potential gradient as well as sodium chemical potential gradient are discussed using the Goldman-Hodgkin-Kats (GHK) and the Nernst equation.
Electrochemical Detection of Hydrogen Peroxide Based on Ag-Deposited Carbon Nanosphere Composites
Authors: Yu Rong , Liu Fuxin , He Nan , Han Lingling , Liu Xiuhui
Published: November 2022

Hydrogen peroxide (H2O2) is closely related to our daily life and health, so it is urgent to accurately detect and analyze its content. Herein, a non-enzymatic H2O2 electrochemical sensor was successfully constructed based on electrodeposited silver nanoparticles (Ag NPs) on carbon nanospheres (CNs). Electrochemical characterization results showed that Ag NPs/CNs/GCE displayed good electrocatalytic performance for H2O2. The diffusion coefficient (D) and heterogeneous rate constant (k0) of hydrogen peroxide were calculated separately. In addition, the sensor had a wide linear range of 4.98 × 10−9 ∼ 7.29 × 10−3 M and a low detection limit of 1.66 × 10−9 M. It also presented excellent anti-interference properties in the presence of various substances. The content of hydrogen peroxide was further detected in real samples of makeup remover, milk and disinfectant with satisfactory recovery rates, confirming its application potential in routine detection.
Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides
Authors: Slominski Andrzej T. , Slominski Radomir M. , Raman Chander , Chen Jake Y. , Athar Mohammad , Elmets Craig
Published: November 2022

The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the largest organ in the human body and it plays a crucial role in the regulation of the body’s homeostasis. These functions are regulated by local neuroendocrine and immune systems with a plethora of signaling molecules produced by resident and immune cells. In addition, neurotransmitters, endocrine factors, neuropeptides, and cytokines released from nerve endings play a central role in the skin's responses to stress. These molecules act on the corresponding receptors in an intra-, juxta-, para-, or autocrine fashion. The epidermis as the outer most component of skin forms a barrier directly protecting against environmental stressors. This protection is assured by an intrinsic keratinocyte differentiation program, pigmentary system, and local nervous, immune, endocrine, and microbiome elements. These constituents communicate cross-functionally among themselves and with corresponding systems in the dermis and hypodermis to secure the basic epidermal functions to maintain local (skin) and global (systemic) homeostasis. The neurohormonal mediators and cytokines used in these communications regulate physiological skin functions separately or in concert. Disturbances in the functions in these systems lead to cutaneous pathology that includes inflammatory (i.e., psoriasis, allergic, or atopic dermatitis, etc.) and keratinocytic hyperproliferative disorders (i.e., seborrheic and solar keratoses), dysfunction of adnexal structure (i.e., hair follicles, eccrine, and sebaceous glands), hypersensitivity reactions, pigmentary disorders (vitiligo, melasma, and hypo- or hyperpigmentary responses), premature aging, and malignancies (melanoma and nonmelanoma skin cancers). These cellular, molecular, and neural components preserve skin integrity and protect against skin pathologies and can act as “messengers of the skin” to the central organs, all to preserve organismal survival.
Antihypertensive Effects of Aqueous Extract of Ricinodendron heudelotii (Baill.) Pierre (Euphorbiaceae) in Wistar Rat
Authors: Wanche Kojom Jacquy Joyce , Bogning Calvin Zangueu , Nguemfo Edwige Laure , Sonfack Christelle Stéphanie , Lappa Edwige Laure , Etamé Loé Gisèle , Llorent-Martínez Eulogio José , Dongmo Alain Bertrand
Published: November 2022

Ricinodendron heudelotii stem bark is commonly used in Cameroonian traditional medicine to treat cardiovascular diseases such as hypertension. The present study was designed to investigate the antihypertensive and antioxidant properties of the aqueous extract of Ricinodendron heudelotii in salt-induced hypertensive rats. Analysis by HPLC-ESI-Q-TOF-MS was used to identify various chemical components of the extract. A total of thirty rats were used for each test. High-salt hypertension was induced in rats by oral administration of NaCl for 12 weeks. Mean blood pressure (MBP) and heart rate (HR) were monitored by noninvasive methods. Oral administration of Ricinodendron heudelotii significantly (

p
<
0.01

) reduced the increase of mean blood pressure (23.12%, 26.14%, and 24.34%) and heart rate (31.19%, 31.09%, and 26.98%), respectively, at the doses of 40, 20, and 6 mg/kg, compared to the hypertensive group. All the doses tested significantly reduced or/and ameliorated biochemical and oxidative stress parameters. Histological analysis showed that Ricinodendron heudelotii restored renal disorders induced by the administration of salt. The aqueous extract of Ricinodendron heudelotii exerts a cardioprotective effect, and the antihypertensive activity seems associated with an improvement in antioxidant status. Overall, the results justify and support the traditional use of Ricinodendron heudelotii.
Ailanthone Inhibits Cell Proliferation in Tongue Squamous Cell Carcinoma via PI3K/AKT Pathway
Authors: Wang Shuhan , Cui Qixiao , Chen Xiaoyu , Zhu Xuejie , Lin Kehao , Zheng Qiusheng , Wang Yuliang , Li Defang
Published: November 2022

Tongue squamous cell carcinoma (TSCC) is the most widespread and invasive subtype of oral cancer with high recurrence rates. Ailanthone (AIL) is an active ingredient in the plant extracts of Ailanthus altissima (Mill.) Swingle. Here, we showed that AIL inhibited the proliferation of human TSCC, the cell viability of Cal-27 and Tca8113 was significantly decreased after AIL treatment for 24 h. Hoechst 33258 staining demonstrated apoptotic characteristics (such as chromatin aggregation) after AIL treatment. The ratio of early- and late-apoptotic cells in AIL-treated Cal-27 and TCA8113 cells increased remarkably when compared with the control group. Bcl-2/Bax ratio and the levels of PARP1, caspase-9, and caspase-3 decreased after AIL treatment, accompanied by significant increase of cleaved PARP1, cleaved caspase-9, and caspase-3 in Cal-27 and TCA8113 cells. Meanwhile, AIL led to Cal-27 cell cycle arrest at G2/M phase. Western blot implied decreased levels of CDK1 and cyclin B1 after AIL treatment. The level of phospho-PI3K p55 subunit and p-Akt were significantly downregulated by AIL in both Cal-27 and TCA8113 cells. These findings implied the potential applications of AIL in the treatment of human TSCC.
Optimization Operation of the Park-Level Integrated Energy System Based on the Improved Coyote Optimization Algorithm
Authors: Li Jiyong , Wang Yasai , Zheng Yifei , Liu Chengye , Xu Xiaoshuai , Chen Ran
Published: November 2022

Conventional optimization methods cannot fully satisfy the interests of multiparticipants and protect the privacy of participants in the integrated energy system that observe changes in the energy market structure. To allocate the benefits among the stakeholders in the integrated energy system and improve renewable energy accommodation, the manuscript proposes an optimal dispatching strategy for a park-level integrated energy system employing the Stackelberg game. Firstly, the benefits and cost models of each stakeholder of the integrated energy system are constructed by considering the integrated demand response and the uncertainty of renewable energy output. A master-slave game model that contains the energy system operator, energy producer, and energy users is then established, and the existence of the Stackelberg equilibrium is demonstrated. Furthermore, a distributed algorithm is proposed to resolve the game model by combining an improved coyote optimization algorithm with quadratic programming. Due to the shortcomings of the conventional coyote optimization algorithm, such as slow convergence rate and quickly falling into local optimum, a beetle antennae search is utilized to strengthen the optimal and the worst coyotes and to improve the convergence speed, global search ability, and optimization accuracy of the standard coyote algorithm. Finally, an industrial park in Northern China is adopted as an illustration to evaluate the effectiveness of the model and the improved algorithm.
Hypertensive Response to Exercise in Athletes: Unremarkable Finding or Relevant Marker for Future Cardiovascular Complications?
Authors: Würzburger Laura , Wiech Patrick , Rossi Valentina A. , Neunhäuserer Daniel , Caselli Stefano , Schmied Christian M. , Niederseer David
Published: November 2022

Background. In the general population, hypertensive response to exercise (HRE) predicts new-onset resting hypertension or other cardiovascular diseases. Methods. PubMed was searched for English articles published between January 1st 2000 and April 30th 2020. Additional studies were identified via reference lists of included studies. 92 papers were selected for full text analysis, finally 30 studies were included. Results. The results from 5 follow-up studies suggested an association between HRE and the risk of developing hypertension, while 10 studies reported a link with adverse cardiovascular events in the general population. Another study showed an association between HRE and future hypertension in athletes after a follow-up of 7 years. HRE in athletes was associated with left ventricular hypertrophy in three studies. Two other studies showed a link between HRE and focal myocardial fibrosis in triathletes and myocardial injury, respectively. One study found lower Apoliprotein-1 serum levels in athletes with HRE leading to a higher risk for cardiovascular disease. Only in one study no association with cardiovascular dysfunction in athletes with HRE was found. Conclusions. Based on current evidence, HRE is not a normal finding in athletes. If detected, it should be interpreted as a risk factor for future cardiovascular complications. Future research should address the adequate follow-up and management of athletes with HRE.
Analysis of Amino Acid Changes in the Fusion Protein of Virulent Newcastle Disease Virus from Vaccinated Poultry in Nigerian Isolates
Authors: Funsho-Sanni Olubukola O. , Ella Elijah E. , Rogo Lawal D. , Sanni Olufunsho S. , Inabo Helen I. , Luka Sodangi A. , Shittu Ismaila
Published: November 2022

The roles of fusion gene in the virulence of Newcastle disease virus are well established, but the extent of its variation among the XIV, XVII, and XVIII genotypes reported in Central Africa and West Africa has until recently been understudied. In this study, virulent Newcastle disease virus (vNDV) was isolated from dead chickens among vaccinated flocks between March and April 2020. Fusion (F) gene was sequenced and analysed for characterization and information about genetic changes. Many substitutions were observed along the region and some of their functions are yet to be determined. Results showed that all study isolates have virulent cleavage site sequence 112-RRRKR-116/F117 and clustered within genotype XIVb. Sequence analysis showed K78R mutation in the A2 antigenic epitope in all isolates and more along the F-gene which varied in some instances within the isolates. Mutation in this A2 antigenic epitope has been reported to induce escape mutation to monoclonal antibodies generated using the NDV LaSota strain. The range of percentage nucleotide and amino acid homology between the study isolates and commercially available vaccine strains is 81.14%–84.39% and 0.175–0.211, respectively. This report provides evidence of vNDV among vaccinated chicken flock and molecular information about circulating vNDV strains in Kano State, Nigeria, which is useful for the development of virus matched vaccines. Newcastle disease (ND) surveillance and molecular analysis of circulating strains in this region should be encouraged and reported. Furthermore, ND outbreaks or cases among vaccinated poultry presented to veterinary clinics should be reported to the state epidemiologist. Nucleotide sequences were assigned accession numbers OK491971–OK491977.