bluuebunny/crossref_metadata_2025 huggingface dataset:
In Vitro Accuracy of Static Guided Implant Surgery Measured by Optical Scan: Examining the Impact of Operator Experience
Authors: Lin Chia-Cheng , Ishikawa Masahiro , Huang Bai-Hung , Huang Mao-Suan , Cheng Hsin-Chung , Maida Takeo , Nezu Takashi , Endo Kazuhiko
Published: April 2020

Studies examining the effect of operator experience on the accuracy of static guided implant surgery have used postoperative computed tomography (CT) images to measure the error, with inconsistent results. The purpose of this study was to try to clarify this issue by using a measurement method based on the postoperative optical scan. Thirty dentists were divided into an experienced group and an inexperienced group. On a partially edentulous mandibular model in the manikin head, each dentist placed three implants via the stereolithographic (SLA) surgical guide. The implant positions were identified by a desktop scanner and compared with the planned positions using a metrology software program. No statistically significant differences were observed for any of the measured positional and angular deviations of the three implant sites between experienced and inexperienced operators (p > 0.01). All the mean values of deviations of the inexperienced group, except the depth deviation, were less than the experienced group. Implants inserted by dentists under 40 years old had significantly better accuracy than senior doctors in the global deviation at implant apex (p = 0.006). Within the limits of this study, we concluded that operator experience is not a critical factor in achieving the accuracy of guided implant surgery via the tooth-supported SLA surgical guide. Large deviations could occur even with the aid of the SLA surgical guide, and care must be taken to avoid errors for both experienced and inexperienced operators.
Study on the Dynamic Soil-Pile-Structure Interactive Behavior in Liquefiable Sand by 3D Numerical Simulation
Authors: Kwon Sun Yong , Yoo Mintaek
Published: April 2020

The dynamic behavior of structures in liquefiable sand exhibits more complicated characteristics, due to the development of excess pore pressure caused by cyclic loading, than that in dry sand. Therefore, it is crucial to accurately predict the soil–pile structure behavior during liquefaction to prevent damage to the structures. In this study, three-dimensional numerical modeling was performed to predict the dynamic soil–pile behavior during liquefaction. To directly simulate pore pressure generation due to soil shear deformation, the Finn liquefaction model was applied and coupled with the Mohr-Coulomb elasto-plastic model. Soil nonlinearity was considered by applying hysteretic damping, and the interface model was applied to simulate various dynamic phenomena between the soil and pile. Simplified continuum modeling was introduced to prevent reflection wave generation and increase analysis efficiency. The applicability of the proposed numerical model was validated using the experimental results. Thereafter, a parametric study was conducted to provide a better understanding of the dynamic behavior of pile foundation during liquefaction. From a series of parametric studies, several important factors that can affect the dynamic pile responses in liquefiable sand were identified. Also, the characteristics of the dynamic soil–pile structure interactive behavior, which are significantly different from each other in liquefied and dry sand, were analyzed qualitatively and quantitatively.
Enhancing the Quality of Sampled Phase-Only Hologram (SPOH) Based on Time-Division Comb Filtering
Authors: Tsang Peter W. M. , Liu Jung-Ping , Lam Hoson , Poon Ting-Chung
Published: April 2020

Generation of digital phase-only Fresnel holograms is an important research area in digital holography, as it leads to a substantial simplification of a holographic display system. However, the quality of the reconstructed image of a hologram without the magnitude component is heavily degraded. The problem can be reduced by down-sampling the intensity of an image prior to generating the hologram. The method, referred to as “sampled phase-only hologram” (SPOH) generation, results in reconstructed images that are masked with the pattern of the down-sampling lattice. This paper reports a novel, low complexity method to alleviate this problem through the concept of comb filtering. Results reveal prominent enhancement on the reconstructed image of a SPOH.
Activin A-Mediated Regulation of XT-I in Human Skin Fibroblasts
Authors: Ly Thanh-Diep , Plümers Ricarda , Fischer Bastian , Schmidt Vanessa , Hendig Doris , Kuhn Joachim , Knabbe Cornelius , Faust Isabel
Published: April 2020

Fibrosis is a fundamental feature of systemic sclerosis (SSc) and is characterized by excessive accumulation of extracellular matrix components like proteoglycans (PG) or collagens in skin and internal organs. Serum analysis from SSc patients showed an increase in the enzyme activity of xylosyltransferase (XT), the initial enzyme in PG biosynthesis. There are two distinct XT isoforms—XT-I and XT-II—in humans, but until now only XT-I is associated with fibrotic remodelling for an unknown reason. The aim of this study was to identify new XT mediators and clarify the underlying mechanisms, in view of developing putative therapeutic anti-fibrotic interventions in the future. Therefore, we used different cytokines and growth factors, small molecule inhibitors as well as small interfering RNAs, and assessed the cellular XT activity and XYLT1 expression in primary human dermal fibroblasts by radiochemical activity assays and qRT-PCR. We identified a new function of activin A as a regulator of XYLT1 mRNA expression and XT activity. While the activin A-induced XT-I increase was found to be mediated by activin A receptor type 1B, MAPK and Smad pathways, the activin A treatment did not alter the XYLT2 expression. Furthermore, we observed a reciprocal regulation of XYLT1 and XYLT2 transcription after inhibition of the activin A pathway components. These results improve the understanding of the differential expression regulation of XYLT isoforms under pathological fibroproliferative conditions.
Photobiomodulation for Parkinson’s Disease in Animal Models: A Systematic Review
Authors: Salehpour Farzad , Hamblin Michael
Published: April 2020

Photobiomodulation (PBM) might be an effective treatment for Parkinson’s disease (PD) in human patients. PBM of the brain uses red or near infrared light delivered from a laser or an LED at relatively low power densities, onto the head (or other body parts) to stimulate the brain and prevent degeneration of neurons. PD is a progressive neurodegenerative disease involving the loss of dopamine-producing neurons in the substantia nigra deep within the brain. PD is a movement disorder that also shows various other symptoms affecting the brain and other organs. Treatment involves dopamine replacement therapy or electrical deep brain stimulation. The present systematic review covers reports describing the use of PBM to treat laboratory animal models of PD, in an attempt to draw conclusions about the best choice of parameters and irradiation techniques. There have already been clinical trials of PBM reported in patients, and more are expected in the coming years. PBM is particularly attractive as it is a non-pharmacological treatment, without any major adverse effects (and very few minor ones).
Floor Slabs Made from Topologically Interlocking Prefabs of Small Size
Authors: Piekarski Maciej
Published: April 2020

In this article, the issue of constructing slabs from unified small elements, which are connected together into a stable structure by topological interlocking, is considered. The state-of-the-art methods in this topic are presented, as well as the results of the author’s original research. The author has expanded the well-known concept of shaping square slabs from square prefabs by the aggregation of triangular and hexagonal slabs from prefabs in the shape of equilateral triangles, regular hexagons, and rhombuses. Each of the slabs can be modelled with upper and bottom surfaces, either both relief, both smooth, or one relief and the other smooth. The slabs can be modelled in different ways, and each one results in intriguing floor and ceiling patterns. All of the slabs can co-operate with grillages made of steel beams, which can be constructed before filling with the prefabricated slab, which is a novel idea. Reversing the assembly order, as compared to that used in the literature, is made possible thanks to division of these elements into parts, to form a keystone which is inserted into the slab as a final step.
The Combined Influence of Dopant Species and Surface Termination on the Electronic Properties of Diamond Surfaces
Authors: Larsson Karin
Published: April 2020

The combined effects of geometrical structure and chemical composition on the diamond surface electronic structures have been investigated in the present study by using high-level theoretical calculations. The effects of diamond surface planes [(111) vs. (100)], surface terminations (H, F, OH, Oontop, Obridge, vs. NH2), and substitutional doping (B, N vs. P), were of the largest interest to study. As a measure of different electronic structures, the bandgaps, work functions, and electron affinities have been used. In addition to the effects by the doping elements, the different diamond surface planes [(111) vs. (100)] were also observed to cause large differences in the electronic structures. With few exceptions, this was also the case for the surface termination species. For example, Oontop-termination was found to induce surface electron conductivities for all systems in the present study (except for a non-doped (100) surface). The other types of surface terminating species induced a reduction in bandgap values. The calculated bandgap ranges for the (111) surface were 3.4–5.7 (non-doping), and 0.9–5.3 (B-doping). For the (100) surface, the ranges were 0.9–5.3 (undoping) and 3.2–4.3 (B-doping). For almost all systems in the present investigation, it was found that photo-induced electron emission cannot take place. The only exception is the non-doped NH2-terminated diamond (111) surface, for which a direct photo-induced electron emission is possible.
Continuous Process for Carbon Dioxide Capture Using Lysine and Tetrabutyl Phosphonium Lysinate Aqueous Mixtures in a Packed Tower
Authors: Zúñiga-Mendiola Antonio de Jesús , Gómora-Herrera Diana Rosa , García-González Juan Manuel , Guzmán-Pantoja Javier
Published: April 2020

The CO2 absorption process using aqueous solutions of lysine (Lys), the ionic liquid (IL) tetrabutyl phosphonium lysinate ([TBP][Lys]) and their mixtures was studied by means of a packed tower. The performance of these systems was evaluated through the volumetric overall mass transfer coefficient ( K G a V ) , conducting experiments under diverse conditions such as inlet CO2 concentration from 10 to 40 vol.%, gas and absorbent flow rates from 100 to 200 mL/min and from 3 to 5 mL/min, respectively, absorbent concentration from 5 to 15 wt.% and temperature from 15 to 40 °C. The obtained results for all the previous experimental conditions were better for the IL/Lys mixture than for the isolated components; the best performance was shown by the experiment varying the absorbent concentration, where the increasing K G a V was benefited by the IL/Lys synergistic effect.
Engineering of Bifunctional Enzymes with Uricase and Peroxidase Activities for Simple and Rapid Quantification of Uric Acid in Biological Samples
Authors: Phuadraksa Thanawat , Chittrakanwong Jurairat , Tullayaprayouch Kittitouch , Onsirisakul Naruthai , Wichit Sineewanlaya , Yainoy Sakda
Published: April 2020

Serum uric acid (SUA) is an important biomarker for prognosis and management of gout and other diseases. The development of a low-cost, simple, rapid and reliable assay for SUA detection is of great importance. In the present study, to save the cost of enzyme production and to shorten the reaction time for uric acid quantification, bifunctional proteins with uricase and peroxidase activities were engineered. In-frame fusion of Candida utilis uricase (CUOX) and Vitreoscilla hemoglobin (VHb) resulted in two versions of the bifunctional protein, CUOX-VHb (CV) and VHb-CUOX (VC). To our knowledge, this is the first report to describe the production of proteins with uricase and peroxidase activities. Based on the measurement of the initial rates of the coupled reaction (between uricase and peroxidase), CV was proven to be the most efficient enzyme followed by VC and native enzymes (CUOX+VHb), respectively. CV was further applied for the development of an assay for colorimetric detection of SUA, which was based on VHb-catalyzed oxidation of Amplex Red in the presence of hydrogen peroxide (H2O2). Under the optimized conditions, the assay exhibited a linear relationship between the absorbance and UA concentration over the range of 2.5 to 50 μM, with a detection limit of 1 μM. In addition, the assay can be performed at a single pH (8.0) so adjustment of the pH for peroxidase activity was not required. This advantage helped to further reduce costs and time. The developed assay was also successfully applied to detect UA in pooled human serum with the recoveries over 94.8%. These results suggest that the proposed assay holds great potential for clinical application.
A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing
Authors: Dash Biraja C. , Setia Ocean , Gorecka Jolanta , Peyvandi Hassan , Duan Kaiti , Lopes Lara , Nie James , Berthiaume Francois , Dardik Alan , Hsia Henry C.
Published: April 2020

The application of human-induced pluripotent stem cells (hiPSCs) to generate vascular smooth muscle cells (hiPSC-VSMCs) in abundance is a promising strategy for vascular regeneration. While hiPSC-VSMCs have already been utilized for tissue-engineered vascular grafts and disease modeling, there is a lack of investigations exploring their therapeutic secretory factors. The objective of this manuscript was to understand how the biophysical property of a collagen-based scaffold dictates changes in the secretory function of hiPSC-VSMCs while developing hiPSC-VSMC-based therapy for durable regenerative wound healing. We investigated the effect of collagen fibrillar density (CFD) on hiPSC-VSMC’s paracrine secretion and cytokines via the construction of varying density of collagen scaffolds. Our study demonstrated that CFD is a key scaffold property that modulates the secretory function of hiPSC-VSMCs. This study lays the foundation for developing collagen-based scaffold materials for the delivery of hiPSC-VSMCs to promote regenerative healing through guiding paracrine signaling pathways.
Genomics and Therapeutic Vulnerabilities of Primary Bone Tumors
Authors: Scotlandi Katia , Hattinger Claudia Maria , Pellegrini Evelin , Gambarotti Marco , Serra Massimo
Published: April 2020

Osteosarcoma, Ewing sarcoma and chondrosarcoma are rare diseases but the most common primary tumors of bone. The genes directly involved in the sarcomagenesis, tumor progression and treatment responsiveness are not completely defined for these tumors, and the powerful discovery of genetic analysis is highly warranted in the view of improving the therapy and cure of patients. The review summarizes recent advances concerning the molecular and genetic background of these three neoplasms and, of their most common variants, highlights the putative therapeutic targets and the clinical trials that are presently active, and notes the fundamental issues that remain unanswered. In the era of personalized medicine, the rarity of sarcomas may not be the major obstacle, provided that each patient is studied extensively according to a road map that combines emerging genomic and functional approaches toward the selection of novel therapeutic strategies.
Activation of the PI3K-AKT Pathway by Old World Alphaviruses
Authors: Van Huizen Eline , McInerney Gerald M.
Published: April 2020

Alphaviruses can infect a broad range of vertebrate hosts, including birds, horses, primates, and humans, in which infection can lead to rash, fever, encephalitis, and arthralgia or arthritis. They are most often transmitted by mosquitoes in which they establish persistent, asymptomatic infections. Currently, there are no vaccines or antiviral therapies for any alphavirus. Several Old World alphaviruses, including Semliki Forest virus, Ross River virus and chikungunya virus, activate or hyperactivate the phosphatidylinositol-3-kinase (PI3K)-AKT pathway in vertebrate cells, potentially influencing many cellular processes, including survival, proliferation, metabolism and autophagy. Inhibition of PI3K or AKT inhibits replication of several alphaviruses either in vitro or in vivo, indicating the importance for viral replication. In this review, we discuss what is known about the mechanism(s) of activation of the pathway during infection and describe those effects of PI3K-AKT activation which could be of advantage to the alphaviruses. Such knowledge may be useful for the identification and development of therapies.
Electrochemical Aptasensor for Detection of Dopamine
Authors: Abu-Ali Hisham , Ozkaya Cansu , Davis Frank , Walch Nik , Nabok Alexei
Published: April 2020

This work presents a proof of concept of a novel, simple, and sensitive method of detection of dopamine, a neurotransmitter within the human brain. We propose a simple electrochemical method for the detection of dopamine using a dopamine-specific aptamer labeled with an electrochemically active ferrocene tag. Aptamers immobilized on the surface of gold screen-printed gold electrodes via thiol groups can change their secondary structure by wrapping around the target molecule. As a result, the ferrocene labels move closer to the electrode surface and subsequently increase the electron transfer. The cyclic voltammograms and impedance spectra recorded on electrodes in buffer solutions containing different concentration of dopamine showed, respectively, the increase in both the anodic and cathodic currents and decrease in the double layer resistance upon increasing the concentration of dopamine from 0.1 to 10 nM L−1. The high affinity of aptamer-dopamine binding (KD ≈ 5 nM) was found by the analysis of the binding kinetics. The occurrence of aptamer-dopamine binding was directly confirmed with spectroscopic ellipsometry measurements.
Static and Dynamic Magnetic Properties of FeGa/FeNi (FeNi/FeGa) Bilayer Structures
Authors: Wang Zhen , Wang Fenglong , Hou Zhaoyang , Xu Chunlong , Cao Derang
Published: April 2020

FeGa/FeNi bilayer structures with different deposition order were fabricated by the electrodeposition method on indium tin oxide (ITO) substrates. The structure, morphology, static and dynamic magnetic properties of FeGa/FeNi (FeNi/FeGa) films were investigated. The bilayer structures exhibit extremely various magnetic properties with different deposition order which could be attributed to the different coupling interaction in the interface. When FeGa is on top, the bilayer structures show lower coercivity than when FeNi is on top. Meanwhile, increase of the proportion of FeNi in the bilayer structure could affect the Hc and Mr/Ms. The ferromagnetic resonance peak of FeGa on top moves to a high field compared with FeNi on top. Moreover, FeGa on top shows improved complex permeability and a clear resonant phenomenon of the magnetization. These properties make FeGa/FeNi bilayer structure a potential candidate for high-frequency application.
Insights into Mapping Solutions Based on OPC UA Information Model Applied to the Industry 4.0 Asset Administration Shell
Authors: Cavalieri Salvatore , Salafia Marco Giuseppe
Published: April 2020

In the context of Industry 4.0, lot of effort is being put to achieve interoperability among industrial applications. As the definition and adoption of communication standards are of paramount importance for the realization of interoperability, during the last few years different organizations have developed reference architectures to align standards in the context of the fourth industrial revolution. One of the main examples is the reference architecture model for Industry 4.0, which defines the asset administration shell as the corner stone of the interoperability between applications managing manufacturing systems. Inside Industry 4.0 there is also so much interest behind the standard open platform communications unified architecture (OPC UA), which is listed as the one recommendation for realizing the communication layer of the reference architecture model. The contribution of this paper is to give some insights behind modelling techniques that should be adopted during the definition of OPC UA Information Model exposing information of the very recent metamodel defined for the asset administration shell. All the general rationales and solutions here provided are compared with the current OPC UA-based existing representation of asset administration shell provided by literature. Specifically, differences will be pointed out giving to the reader advantages and disadvantages behind each solution.
Rod-Shaped Carbon Aerogel-Assisted CdS Nanocomposite for the Removal of Methylene Blue Dye and Colorless Phenol
Authors: Prasad Saradh , Shanmugam P. , Bhuvaneswari K. , Palanisamy G. , Pazhanivel T. , Arunkumar T. , AlSalhi Mohamed Saleh , Aljaafreh Mamduh J.
Published: April 2020

A carbon aerogel (CA)-assisted CdS nanocomposite was prepared by hydrothermal process and was investigated as a photocatalyst towards the photodegradation of methylene blue (MB) dye and colorless phenol under visible light irradiation (VLI). CdS have attracted wide attention due to their relatively narrow band gap for the visible light effect and the suitably negative potential of the conduction band (CB) edge for the neutralization of H+ ions. The obtained characterization results suggest that the CA-assisted CdS nanocomposite has enhanced photophysical properties, a more surface area, and the desired morphology at the nm scale. Under optimization, CdS CA 8% shows superior catalytic activity for degradation compared with other samples. The photocatalytic activities of the as-synthesized samples were examined under VLI through the MB and phenol degradation. Compared with pure CA and CdS, the CA (8%)-assisted CdS nanoparticles (NPs) offer significantly enhanced photocatalytic efficiency for MB and phenol. The mechanism of photocatalytic reaction was examined by adding various scavengers, and the results revealed that the holes generated in CA (8%)-assisted CdS NPs have a crucial impact on the visible light photocatalytic process. The improved photocatalytic degradation was due to the strong interaction between the CA and CdS NPs.
Diagnosis of Dizziness Due to a Core Vestibular Projection Injury in a Patient with Intracerebral Hemorrhage
Authors: Kwon Hyeok Gyu , Chang Chul Hoon , Jang Sung Ho
Published: April 2020

Herein, we present a patient diagnosed with dizziness due to a core vestibular projection injury following intracerebral hemorrhage (ICH). A 51-year-old female patient underwent conservative management for a spontaneous ICH in the left hemisphere (mainly affecting the basal ganglia and insular cortex). When she visited the rehabilitation department of the university hospital at two years after the ICH onset, she advised of the presence of moderate dizziness (mainly, light-headedness) that started after ICH onset. She mentioned that her dizziness had decreased slightly over time. No abnormality was observed in the vestibular system of either ear on physical examination by an otorhinolaryngologist. However, diffusion tensor tractography results showed that the core vestibular projection in the left hemisphere was discontinued at the basal ganglia level compared with the patient’s right core vestibular projection and that of a normal subject. Therefore, it appears that the dizziness in this patient can be ascribed to a left core vestibular projection injury.
From Donor to Patient: Collection, Preparation and Cryopreservation of Fecal Samples for Fecal Microbiota Transplantation
Authors: Nicco Carole , Paule Armelle , Konturek Peter , Edeas Marvin
Published: April 2020

Fecal Microbiota Transplantation (FMT) is suggested as an efficacious therapeutic strategy for restoring intestinal microbial balance, and thus for treating disease associated with alteration of gut microbiota. FMT consists of the administration of fresh or frozen fecal microorganisms from a healthy donor into the intestinal tract of diseased patients. At this time, in according to healthcare authorities, FMT is mainly used to treat recurrent Clostridium difficile. Despite the existence of a few existing stool banks worldwide and many studies of the FMT, there is no standard method for producing material for FMT, and there are a multitude of factors that can vary between the institutions. The main constraints for the therapeutic uses of FMT are safety concerns and acceptability. Technical and logistical issues arise when establishing such a non-standardized treatment into clinical practice with safety and proper governance. In this context, our manuscript describes a process of donor safety screening for FMT compiling clinical and biological examinations, questionnaires and interviews of donors. The potential risk of transmission of SARS-CoV-2 virus by the use of fecal microbiota for transplantation must be taken urgently into consideration. We discuss a standardized procedure of collection, preparation and cryopreservation of fecal samples through to the administration of material to patients, and explore the risks and limits of this method of FMT. The future success of medicine employing microbiota transplantation will be tightly related to its modulation and manipulation to combat dysbiosis. To achieve this goal, standard and strict methods need to be established before performing any type of FMT.
Energy-Efficient Ternary Multipliers Using CNT Transistors
Authors: Tabrizchi Sepehr , Panahi Atiyeh , Sharifi Fazel , Mahmoodi Hamid , A. Badawy Abdel-Hameed
Published: April 2020

In recent decades, power consumption has become an essential factor in attracting the attention of integrated circuit (IC) designers. Multiple-valued logic (MVL) and approximate computing are some techniques that could be applied to integrated circuits to make power-efficient systems. By utilizing MVL-based circuits instead of binary logic, the information conveyed by digital signals increases, and this reduces the required interconnections and power consumption. On the other hand, approximate computing is a class of arithmetic computing used in systems where the accuracy of the computation can be traded-off for lower energy consumption. In this paper, we propose novel designs for exact and inexact ternary multipliers based on carbon-nanotube field-effect transistors (CNFETs). The unique characteristics of CNFETs make them a desirable alternative to MOSFETs. The simulations are conducted using Synopsys HSPICE. The proposed design is compared against existing ternary multipliers. The results show that the proposed exact multiplier reduces the energy consumption by up to 6 times, while the best inexact design improves energy efficiency by up to 35 time compared to the latest state-of-the-art methods. Using the imprecise multipliers for image processing provides evidence that these proposed designs are a low-power system with an acceptable error.
Thermochromic Paints on External Surfaces: Impact Assessment for a Residential Building through Thermal and Energy Simulation
Authors: Granadeiro Vasco , Almeida Margarida , Souto Tiago , Leal Vítor , Machado João , Mendes Adélio
Published: April 2020

This work addresses the effect of using thermochromic paints in residential buildings. Two different thermochromic paint types were considered: One that changes properties through a step transition at a certain temperature, and another that changes properties in a gradual/linear manner throughout a temperature range. The studied building was a two-floor villa, virtually simulated through a digital model with and without thermal insulation, and considering thermochromic paints applied both on external walls and on the roof. The performance assessment was done through the energy use for heating and cooling (in conditioned mode), as well as in terms of the indoor temperature (in free-floating mode). Three different cities/climates were considered: Porto, Madrid, and Abu Dhabi. Results showed that energy savings up to 50.6% could be reached if the building is operated in conditioned mode. Conversely, when operated in free-floating mode, optimally selected thermochromic paints enable reductions up to 11.0 °C, during summertime, and an increase up to 2.7 °C, during wintertime. These results point out the great benefits of using optimally selected thermochromic paints for obtaining thermal comfort, and also the need to further develop stable and cost-effective thermochromic pigments for outdoor applications, as well as to test physical models in a real environment.
The Challenges of Open-Pit Mining in the Vicinity of the Salt Dome (Bełchatów Lignite Deposit, Poland)
Authors: Cała Marek , Cyran Katarzyna , Jakóbczyk Joanna , Kowalski Michał
Published: April 2020

The extraction of the Bełchatów lignite deposit located in the vicinity of the Dębina salt dome requires careful planning that considers the influence of mining projects on the slope and salt dome stability conditions. The instability problem is directly related to horizontal and vertical displacement, as well as the complex geological and mining conditions. These conditions are very unique with regard to the co-occurrence of the salt dome and lignite deposits in the same area, as well as the large scale of the pit wall slope. Thus, predicting rock mass behavior and ensuring the safety of mining operations are important issues. The presented analysis focused on the influence of long-term lignite extraction on the western pit wall slope of the Bełchatów field and the salt dome’s stability conditions. This study offers a comprehensive approach to a complex geotechnical problem defined by large-scale, complex geometry, and geological conditions. The rock mass behavior and stress conditions are simulated in numerical modelling. The results of the presented analysis will be useful not only for present mining activities but also for future developments related to post-mining and recultivation plans.
Evaluation of Load Matching Indicators in Residential PV Systems-the Case of Cyprus
Authors: Gjorgievski Vladimir Z. , Chatzigeorgiou Nikolas G. , Venizelou Venizelos , Christoforidis Georgios C. , Georghiou George E. , Papagiannis Grigoris K.
Published: April 2020

Three load matching indicators (self-consumption rate, self-sufficiency rate, loss of load probability) and the CO2 emissions were evaluated for 55 Cypriot households with 3 kWp rooftop photovoltaic (PV) generators. The calculations were performed using 30-minute generation and consumption data from a large scale smart meter project in Cyprus. To investigate the effects of recent advances in local legislation, an analysis for higher PV capacities (5 kWp and 10 kWp) was also performed. The PV generation profiles for 5 kWp and 10 kWp PVs were obtained by scaling the 3 kWp PV generation profiles. The results showed that the self-consumption of the analyzed households varied seasonally, as it was related to their heating and cooling demand. More interestingly, the ratio between the households’ annual electricity generation and demand, formally defined here as generation-to-demand ratio (GTDR), was found to be related to the value ranges of the studied load matching indicators. Hence, on average, households with 3 kWp PV generators annually self-consumed 48.17% and exported 2,415.10 kWh of their PV generation. On the other hand, households with larger PV generators were characterized by a higher GTDR, but lower load matching capabilities. For the cases of 5 kWp and 10 kWp PV generators, the average self-consumption fell to 34.05% and 19.31%, while the exported PV generation was equal to 5,122.47 kWh, and 12,534.90 kWh, respectively. Along with lower load matching capabilities, households that generated more than they consumed were also found to have a lower potential for CO2 emissions reduction per installed kWp within the boundaries of the building. In this context, the GTDR could be used by stakeholders to characterize buildings, infer possible value ranges of more complex indicators and make evidence based decisions on policy and legislation.
Public Preferences in a Shifting Energy Future: Comparing Public Views of Eight Energy Sources in North America’s Pacific Northwest
Authors: Hazboun Shawn Olson , Boudet Hilary Schaffer
Published: April 2020

The U.S. and Canada continue to face major changes in energy production. Mounting awareness of the climate crisis has placed increasing importance on developing renewable energy sources, however, advances in fossil fuel extraction technology have opened vast domestic reserves of oil and natural gas. Public preferences for energy policy play a role in determining energy futures, but researchers rarely simultaneously compare public views across multiple renewable and non-renewable energies or across country boundaries. Here, we used a 2019 online survey sample (n = 1500) to compare predictors of support for eight fuel sources for electricity generation in British Columbia, Canada, and Washington and Oregon, USA. Results indicate the highest support overall for renewables (wind, solar, wave/tidal energy, geothermal) and the lowest for fossil fuels (coal and natural gas), nuclear, and hydropower. Mixed-effects regression modeling indicates that views on climate and the balance between environment and economy were consistent predictors of support across most energy types, while political ideology was less consistent. Perceived local importance of both extractive and renewable energy industries were significant predictors of support for some, but not all, energy sources, as were education and gender. Overall, our research suggests that while divisions persist in public energy preferences for both renewable and non-renewable sources, there is the broadest support for renewable energy technologies.
Trusted Simulation Using Proteus Model for a PV System: Test Case of an Improved HC MPPT Algorithm
Authors: Chalh Abdelilah , El Hammoumi Aboubakr , Motahhir Saad , El Ghzizal Abdelaziz , Subramaniam Umashankar , Derouich Aziz
Published: April 2020

The real implementation of the maximum power point tracking (MPPT) controllers for the photovoltaic (PV) systems is still a big challenge for researchers working in this field. Often, they use simulation tools to assess the performance of their MPPT algorithms before actual implementation. In this context, this paper aims to propose a trusted simulation of a PV system designed under Proteus software. The proposed PV simulator can be used to verify and evaluate the performance of MPPT algorithms with a closer approximation to the real implementation. The main advantage of this model that it contains a real microcontroller, as can be found in reality, so that same code for the MPPT algorithm used in the simulation will be used in real implementation. In contrast, when using (Powersim Software) PSIM or Matlab/Simulink, the code of the algorithm must be rewritten once the real experiment begins, because these tools don’t provide a microcontroller or an electronic board in which our algorithm can be implemented and tested in the same way as the real experiment. After this section, a modified Hill-Climbing (HC) algorithm is introduced. The proposed algorithm can avoid the drift problem posed by conventional HC under a fast variation in insolation. The simulation results show that this method presents good performance in terms of efficiency (99.21%) and response time (10 ms), which improved by 1.2% and 70 ms respectively compared to the conventional HC algorithm.
The Spatial and Temporal Variability of the Effects of Agricultural Practices on the Environment
Authors: Fanelli Rosa Maria
Published: April 2020

It is widely known that agricultural practices can alter natural ecosystems, both from a qualitative and quantitative point of view. Indeed, over the years, the intensification of production through excessive or inappropriate use of pesticides and fertilisers in the agricultural sector has had a negative impact on natural resources. This negative environment impact has had both minor and major consequences for the natural resources present in the different areas of the European Union (EU). This variability depends mainly on the different agricultural training of farmers and on their ability to practise sustainable agriculture. Hence, with a specific set of agri-environmental indicators provided by the Eurostat database, this paper analyses the spatial and temporal variation of the agricultural land-use practices and the related environmental effects in EU countries. In pursuit of this aim, descriptive statistics and multivariate analysis (factor analysis and hierarchical cluster analysis) were adopted to determine the similarities/dissimilarities between the different types of agricultural production in the EU and the dominant dimensions of agricultural production and activities there in terms of their impact of natural resources in order to identify “homogeneity” among member states. The main contribution of this paper lies, above all, in the fact that the classification of these countries in four agro-ecosystems, with similar use of energy, pollution factors, and natural resources, could be useful as a tool for policymakers. Importantly, it could help them to define different incentives that could encourage farmers to adopt more sustainable agricultural production methods.
A Guide for the Food Industry to Meet the Future Skills Requirements Emerging with Industry 4.0
Authors: Akyazi Tugce , Goti Aitor , Oyarbide Aitor , Alberdi Elisabete , Bayon Felix
Published: April 2020

The food industry has recently faced rapid and constant changes due to the current industrial revolution, Industry 4.0, which has also profoundly altered the dynamics of the industry overall. Due to the emerging digitalisation, manufacturing models are changing through the use of smart technologies, such as robotics, Artificial Intelligence (AI), Internet of Things (IoT), machine learning, etc. They are experiencing a new phase of automation that enables innovative and more efficient processes, products and services. The introduction of these novel business models demands new professional skills requirements in the workforce of the food industry. In this work, we introduce an industry-driven proactive strategy to achieve a successful digital transformation in the food sector. For that purpose, we focus on defining the current and near-future key skills and competencies demanded by each of the professional profiles related to the food industry. To achieve this, we generated an automated database of current and future professions and competencies and skills. This database can be used as a fundamental roadmap guiding the sector through future changes caused by Industry 4.0. The interest shown by the local sectorial cluster and related entities reinforce the idea. This research will be a key tool for both academics and policy-makers to provide well-developed and better-oriented continuous training programs in order to reduce the skill mismatch between the workforce and the jobs.
Black Boys’ and Young Men’s Experiences with Criminal Justice and Desistance in England and Wales: A Literature Review
Authors: Robertson Laura , Wainwright John Peter
Published: April 2020

Black boys and young men are over-represented in the youth and adult justice systems in England and Wales. Despite the Lammy Review (2017) into the treatment of and outcomes for Black, Asian, and minority ethnic individuals (BAME) in the criminal justice system, the disproportionate numbers of Black boys and young men at all stages of the system continue to rise. There has been limited qualitative research of Black boys’ and young men’s experiences with the justice system in England and Wales. In particular, there is a lack of evidence on their experiences with sentencing and courts. What is known tends to focus on Black, Asian, and minority ethnic and/or Muslim men’s experiences more generally. A lack of critical understanding of the specific experiences of desistance by young Black men has been criticised in the literature. Set in this context, this review of UK literature focuses on the following questions: (1) What are Black boys’ and young Black men’s experiences with the youth and criminal justice systems in England and Wales? (2) What does research tell us specifically about their experiences with desistance?
Comparative Transcriptomic Analysis of Subcutaneous Adipose Tissue from Local Pig Breeds
Authors: Albuquerque André , Óvilo Cristina , Núñez Yolanda , Benítez Rita , López-Garcia Adrián , García Fabián , Félix Maria do Rosário , Laranjo Marta , Charneca Rui , Martins José Manuel
Published: April 2020

When compared to modern lean-type breeds, Portuguese local Alentejano (AL) and Bísaro (BI) pig breeds present a high potential for subcutaneous and intramuscular fat (IMF) deposition which contributes for better meat quality. The aim of this work was to explore the genome function to better understand the underlying physiological mechanisms associated with body fat accretion. Dorsal subcutaneous fat samples were collected at slaughter from adult animals (n = 4 for each breed) with ~150 kg body weight. Total RNA was obtained and sequenced for transcriptome analysis using DESeq2. A total of 458 differentially expressed (DE) genes (q-value < 0.05) were identified, with 263 overexpressed in AL and 195 in BI. Key genes involved in de novo fatty acid biosynthesis, elongation and desaturation were upregulated in AL such as ACLY, FASN, ME1, ELOVL6 and SCD. A functional enrichment analysis of the DE genes was performed using Ingenuity Pathway Analysis. Cholesterol synthesis is suggested to be higher in AL via SREBF2, SCAP and PPARG, while lipolytic activity may be more active in BI through GH and AMPK signalling. Increased signalling of CD40 together with the predicted activation of INSIG1 and INSIG2 in BI suggests that this breed is more sensitive to insulin whereas the AL is less sensitive like the Iberian breed.
A Multi-Objective Permanent Basic Farmland Delineation Model Based on Hybrid Particle Swarm Optimization
Authors: Wang Hua , Li Wenwen , Huang Wei , Nie Ke
Published: April 2020

The delimitation of permanent basic farmland is essentially a multi-objective optimization problem. The traditional demarcation methods cannot simultaneously take into account the requirements of cultivated land quality and the spatial layout of permanent basic farmland, and it cannot balance the relationship between agriculture and urban development. This paper proposed a multi-objective permanent basic farmland delimitation model based on an immune particle swarm optimization algorithm. The general rules for delineating the permanent basic farmland were defined in the model, and the delineation goals and constraints have been formally expressed. The model introduced the immune system concepts to complement the existing theory. This paper describes the coding and initialization methods for the algorithm, particle position and speed update mechanism, and fitness function design. We selected Xun County, Henan Province, as the research area and set up control experiments that aligned with the different targets and compared the performance of the three models of particle swarm optimization (PSO), artificial immune algorithm (AIA), and the improved AIA-PSO in solving multi-objective problems. The experiments proved the feasibility of the model. It avoided the adverse effects of subjective factors and promoted the scientific rationality of the results of permanent basic farmland delineation.
A Study on Magnetic Removal of Hexavalent Chromium from Aqueous Solutions Using Magnetite/Zeolite-X Composite Particles as Adsorbing Material
Authors: Kouli Maria-Elisavet , Banis George , Savvidou Maria G. , Ferraro Angelo , Hristoforou Evangelos
Published: April 2020

Toxic and heavy metals are considered harmful derivatives of industrial activities; they are not biodegradable and their accumulation in living organisms can become lethal. Among other heavy and toxic metals, chromium is considered hazardous, especially in the hexavalent (Cr6+) form. Numerous established studies show that exposure to Cr6+ via drinking water leads to elevated chromium levels in tissues, which may result in various forms of cancer. The purpose of this research is to synthesize magnetite/zeolite-X composite particles for the adsorption and magnetic removal of Cr6+ ions from aqueous solutions. Synthesis and characterization of such composite nanomaterials, along with an initial experimental evaluation of Cr6+ removal from water-based solution, are presented. Results show that zeolite-X is a very promising zeolite form, that when bound to magnetic nanoparticles can be used to trap and magnetically remove toxic ions from aqueous solutions.
miR−21 and NT-proBNP Correlate with Echocardiographic Parameters of Atrial Dysfunction and Predict Atrial Fibrillation
Authors: Sieweke Jan-Thorben , Pfeffer Tobias Jonathan , Biber Saskia , Chatterjee Shambhabi , Weissenborn Karin , Grosse Gerrit M. , Hagemus Jan , Derda Anselm A. , Berliner Dominik , Lichtinghagen Ralf , Hilfiker-Kleiner Denise , Bauersachs Johann , Bär Christian , Thum Thomas , Bavendiek Udo
Published: April 2020

This study aimed to investigate the association of circulating biomarkers with echocardiographic parameters of atrial remodelling and their potential for predicting atrial fibrillation (AF). In patients with and without AF (n = 21 and n = 60) the following serum biomarkers were determined: soluble ST2 (sST2), Galectin−3 (Gal-3), N-terminal pro-brain natriuretic peptide (NT-proBNP), microRNA (miR)−21, −29a, −133a, −146b and −328. Comprehensive transthoracic echocardiography was performed in all participants. Biomarkers were significantly altered in patients with AF. The echocardiographic parameter septal PA-TDI, indicating left atrial (LA) remodelling, correlated with concentrations of sST2 (r = 0.249, p = 0.048), miR−21 (r = −0.277, p = 0.012), miR−29a (r = −0.269, p = 0.015), miR−146b (r = −0.319, p = 0.004) and miR−328 (r = −0.296, p = 0.008). In particular, NT-proBNP showed a strong correlation with echocardiographic markers of LA remodelling and dysfunction (septal PA-TDI: r = 0.444, p < 0.001, LAVI/a’: r = 0.457, p = 0.001, SRa: r = 0.581, p < 0.001). Multivariate Cox regressions analysis highlighted miR−21 and NT-proBNP as predictive markers for AF (miR−21: hazard ratio (HR) 0.16; 95% confidence interval (CI) 0.04–0.7, p = 0.009; NT-proBNP: HR 1.002 95%CI 1.001–1.004, p = 0.006). Combination of NT-proBNP and miR−21 had the best accuracy to discriminate patients with AF from those without AF (area under the curve (AUC)= 0.843). Our findings indicate that miR−21 and NT-proBNP correlate with echocardiographic parameters of atrial remodeling and predict AF, in particular if combined.