bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular docking study of phytochemical compounds from Kustakudori ennai as a potential anti-alopecia treatment
Authors: Elangovan Nandhini , P Chakravarthi , S Kanimozhi
Published: July 2024

Background:
In the case of alopecia, the scalp's hair may completely or partially lost. The 5--reductase enzyme has been inhibited as a recent prophylactic treatment. Diahydrotestosterone, a more potent metabolite of testosterone, is produced when the enzyme 5--reductase is inhibited.
 Literature:
Kushtakudori ennai, Siddha poly herbal drug is used as a Alopecia medicine mentioned in the literature Prana rakshamirtha sindhu.This research aimed to test activity of 9 known compounds contained within the herbs of Kushtakudori ennai as anti-alopecia.
Methodology:
Utilizing molecular docking and the Auto doc program, functionality was determined on their interaction with the androgen receptor (PDB code 4K7a). The steps in the research process were: creating databases of androgen protein structures; creating and perfecting three-dimensional structures of compounds; utilizing Autodock 1.5.6 to dock molecules to the androgen receptor protein; and using the pkCSM tool to estimate ADME-Tox.
Observation and Inference:
Total of 9 bioactive lead compounds were retrieved from the ingredients present on the polyherbal siddha formulation. From the reported data of the herbs, the phytochemicals such as 
Oleic acid, Chebuloside, Friedelin, Maslinic acid, Piperine, Isovitexin, Astragalin, Salsoline and Alangicine. The compound’s like Astragalin, Chebuloside, Friedelin and Piperine reveals maximum of four to five interactions with the bioactive residues present on the target androgen receptor. Other components such as Isovitexin, Salsoline, Maslinic acid and Alangicine revels maximum of three viable interactions with the target in comparison with standard drug Finasteride.
Conclusion:
Based on the results of the computational analysis it was concluded that the bio-active compound’s like Astragalin, Chebuloside, Friedelin, Piperine, Isovitexin, Salsoline, Maslinic acid and Alangicine reveals prominent interaction with active site of the receptor thereby it may hinder the binding of native ligand and also limit the follicle shrinkage and subsequent hair fall process. Hence it was concluded that the aforementioned phytocompounds may exerts promising anti-alopecia activity.
Development of stability indicating RP-HPLC method for Quercetin estimation in Nanostructure liquid crystalline dispersion
Authors: Kurangi Bhaskar , Jalalpure Sunil , Mayuri Joshi  , Umesh Patil
Published: July 2024

An attempt has been made to develop stability representing the reverse-phase High-Performance Liquid Chromatography (RP-HPLC) method for quantitative estimation of quercetin Nanostructure liquid crystalline dispersion. HPLC method was developed by C-18 column with the mobile phase comprising of 0.4% orthophosphoric acid [OPA]: Acetonitrile [ACN] (45:55, v/v), isocratically pumped with a rate of flow 1 mL/min and 255 nm detection wavelength. The method validation of HPLC parameters and degradation tests was analysed by International Conference on Harmonization (ICH) guidelines. The developed HPLC method was found to be specific, linear (r2>0.999) over the selected range of concentration 2-14μg/mL, precise, with the limit of detection (LOD) and limit of quantification (LOQ) as 0.021 and 0.064μg/mL respectively. The entrapment efficiency of quercetin for prepared Nanostructure Liquid Crystalline Dispersion (NLCD) was observed to be 94.55 %. The developed HPLC method was applied for the quantification of quercetin in NLCD. The quercetin peak was completely resolved without any disturbances from degrading products and additives. The developed HPLC method was found to be specific, sensitive, and adequate for the regular assay of marketed products, and NLCD nanoformulation containing quercetin.
Evaluation of the physiological and pathological status of Stanya (Breast milk) based on the Ayurveda principles and Physico-chemical analysis- A Cross-sectional study
Authors: Wahlang Nishahun , Rathi Renu
Published: July 2024

Background: In Ayurveda, Stanya Dosha was described by almost all Acharya stating the Dushti of breast milk which is not accepted by modern sciences as they perceived that breast milk is exclusively advised to all neonates and there is no such description to examine the abnormality of breast milk. As Ayurveda literature is Shaswat (eternal) which gives us a reason for the need to provide evidence or scientific explanation to support our literature. To make the world aware of Stanya Dushti, scientific evidences must be provided for other scientific systems to embrace the notion. Aim: To assess the quality of Stanya by examining its features as told in Ayurveda literature and its physicochemical properties. Objectives: To establish assessment criteria to assess Stanya Dushti through basic sciences. To assess the Stanya by observing the organoleptic property. Experiment with its physicochemical properties of protein estimation, viscosity, pH, value, and density. To assess the Dosha of breast milk by Jala pariksha(Dispersion method). Materials and methods: Observational study on breast milk of 60 lactating mothers collected from mothers coming for vaccination & OPD of MGACH&RC, PHC Salod, Wardha. Observation: 38.3% were Shuddha and 61.7% were Ashuddha with 11.7%Vatapitta, 25% Kaphapitta, 11.7%Vata, 5% Pitta,and 8.3% Kaphadominance. Mean values of pH, viscosity, density, and protein were found as 6.91, 1.64 cP, 1.02 gm/cc, and 1.72% respectively. Result: The breast milk of Shuddha stanya part was 38.3% and that of Dushti was 61%. The dominance of Dosha shows highly significance with Prakriti. The infants with Stanya Dushti show significant risks of developing clinical symptoms of GIT and the respiratory system.
Role of T-AYU-HM Premium in Paediatric Patients with Sickle Cell Anaemia: A Retrospective Case Series
Authors: Desai Atul , Desai Kavita , Desai Hemshree , Desai Rutvij , Desai Chirag
Published: July 2024

Background: Sickle cell disease (SCD), a genetic disorder caused by a beta globin chain mutation, has been recognized as influencing public health worldwide. In India, numerous tribal and underdeveloped groups frequently suffer from this medical condition. The present study evaluates the effectiveness and safety of alternative medicines T-AYU-HM Premium among paediatric SCD patients. Methodology: A single-arm retrospective observational case series of 10 sickle cell disease paediatric population were conducted. The proposed study was conducted to clinically evaluate the safety and effectiveness of T-AYU-HM Premium Tablet (300mg) on paediatric individuals. The clinical and vital data of the patients were collected, evaluated, and reported using the SPSS software based on inclusion and exclusion criteria. Results: The study had a majority of male (80%) patients with a mean age of 3.20±1.23 years. The present study also identified consanguinity. It also observed a non-significant improvement in weight (12.04 ± 2.45) compared to the baseline (11.64 ± 2.46). There was also a non-significantly decrease in the pulse rate from baseline. In terms of hematological parameters, no significant change was observed from the baseline. However, there was a substantial decrease in pain-associated clinical parameters among the paediatric population. Conclusion: The present retrospective analysis shows that patients with SCD were significantly improved by the T-AYU-HM Premium treatment, proving both its efficacy and safety, particularly in pain management. However, the current analysis suggests a substantial body of evidence (prospective) to support using herbal-mineral formulations for sickle cell anaemia among paediatric patients.
A report on ethnomedicinal plants used for the treatment of Rheumatoid arthritis by the tea tribes of Morigaon district of Assam, India
Authors: Bhattacharyya Rakhi , Mehmud Selim , Medhi Krishna Kanta , Borkataki Sarat
Published: July 2024

The present study deals with the documentation of ethnomedicinal plants used against rheumatoid arthritis by the tea tribe community of Morigaon district of Assam. The tea tribes of the district still rely on herbal remedies for curing rheumatoid arthritis. To document the plant species used by tea tribes against rheumatoid arthritis, frequent study field surveys were conducted in different places of the district. A semi-structured questionnaire on traditional knowledge was used to elicit information from the concerned tribe of the study area. The documented data was evaluated using quantitative ethnobotanical indices like Use Value (UV) and Fidelity Level Percentage (FL %). From the study, a total of 33 plants belonging to 32 genera under 24 families were documented. The data was evaluated using quantitative ethnobotanical indices like Use Value and Fidelity Level Percentage. Five species were found having the highest use value and four species showed fidelity levels of 100 %. Further research is required to investigate the pharmacological effects and the chemical constituents present in the plant species that could be the basis for developing some novel product in the future.
A Siddha Management of Attai vidal with internal and external medicines for Naalavibatha Punn (Varicose Ulcer): A Case Report
Authors: Christian CBS Bharath , Devi P Nirmala , Shiny S Ethel , J Jayalakshmi
Published: July 2024

According to various classical Siddha literature, the varicose ulcer is compared with the symptoms of Naalavibatha punn / Naalasurrutu punn / Naalaviruvu punn. Treat varicose ulcers by prescribing Siddha internal medicines and external therapies. On August 5, 2022, a 48-year-old female patient attended the OPD of Santhigiri Siddha Medical College and Hospital, Trivandrum, with the following complaints: dilatation of veins, present in the right lower limb for 6 years; hyperpigmented lesion with itching and swelling above the medial malleolus of the right lower limb for 6 months; and an ulcer present above the medial malleolus for the last 3 months. She had a known case of varicose veins and had taken sclerotherapy three times but did not have satisfaction with the allopathic medication. The majority of the symptoms were significantly reduced in 60 days under the Siddha medications, such as a combination of Siddha preparation (Parangipattai Chooranam, Sangu Parpam, and Silasathu Parpam), Rasa gandhi mezhugu for internal, Padikara neer washing, wound dressing with Mathan thailam for external for 2 months, and attai vidal (leech application) done in 3 sittings in the gap of 10 days. No recurrence of any chronic varicose ulcer was observed during the 1 year of follow-up, and relevant preventive Siddha medication for Naalavibatha punn was given. The doctor advised the patient to do exercises that strengthen the legs and compression therapy. To summarize, the case report exhibited that Siddha leech therapy with both internal and external medications is very effective in the management of varicose ulcers.
Insilico Studies Unveiling the Hepatoprotective Potential of Morus alba Linn: Docking and ADMET Analysis
Authors: Lichade Abha , Deshmukh Aayushi , Nakhate Yashwant , Kalambe Pranali
Published: July 2024

The goal of the drug discovery process is to search for new drug molecules which can bind to a specific target known to be involved in causing a disease. This study aims to identify potential inhibitors against the TGF-β-type-I receptor (PDB Id-1VJY) by developing ligands through molecular docking and ADMET-based virtual screening. The plant-based nature product database of Morus alba Linn  is utilized for this purpose. The resultants hits, identified as actives were evaluated by molecular docking studies to get insight into their potential binding interaction with the target protein. 1-deoxynojirimycin (A1), Catechin (A2), Cyanidine-3-rutinoside (A3), Cyclomulberrin (A4), Kaempferol (A5), Kuwanon-G (A6), Morusin (A7), Mulberrin (A8), Mulberrofuran-G (A9), Quercetin-3-(6-malonylglucoside) (A10), Quercitrin (A11), Rutin (A12), were selected for the molecular docking.ADMET based virtual screening ligand/Compound (A1, A2, A4, A5, A7, A8, A9) passes the lipinski’s rule. Compound A4 (-10.7 kcal/mol), A5 (-10.4 kcal/mol) and A8 (-9.9 kcal/mol) had the highest binding affinity to the active site in TGF-β-type-I receptor. In conclusion, based on docking score and ADMET virtual screening, Cyclomulberrine (A4) (-10.7 kcal/mol) more affinity toward the TGF-β-type-I receptor that could be investigated further in the search for Hepatoprotective agent.
Determination of Minimal Inhibitory Concentration of Gel containing combination of Picrorhiza Kurroa and Ficus Benghalensis for Treatment of Periodontitis
Authors: Rathod Surekha , Kaule Supriya S , Bawankar Pranjali
Published: July 2024

Background: The therapeutic effects of Picrorhiza kurroa Royle ex benth and Ficus benghalensis L. for treatment of chronic inflammatory diseases is well known. Objective: The purpose of the present study is assessment of the efficacy of gel containing combination of Picrorhiza kurroa Royle ex benth and Ficus benghalensis L. against periodontopathogens and hydroalcoholic extracts of Picrorhiza kurroa Royle ex benth (PK) and Ficus benghalensis L. (FB) against periodontopathogens. Material & Methods:  The preparation of the herbal Water extracts, Alcohol extracts and Hydro Alcoholic extracts was done by Soxhlet extraction method. MIC of different extracts of PK and FB and its combination was determined. Results: The MIC of the PK water extract against Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) was 0.8 μg/ml. For Aa and Pg, the MIC of water extract of FB was 1.6 μg/ml and 6.25 μg/ml, respectively. The combination of PK and FB alcoholic extract was shown to have a MIC of 1.6 μg/ml. Conclusion: The presence of antibacterial activity could be confirmed in periodontopathogens species which were assayed in this study. However, the MIC for the species employed showed a very large range, and were mostly very high. Nevertheless, traditional knowledge might provide some leads to elucidate potential candidates for future development of new antibiotic agents.
The effect of an Indian traditional Ayurvedic formulation (Rasa-sindoor) on Parkinson disease mouse model
Authors: Halder Tamali , Gupta Sameer , Haldar Chandana , Das Parimal
Published: July 2024

Ayurveda is a traditional medication system in India. Experimental validation of ayurvedic formulations to combat with progressive, non-curable diseases like cancer, neurodegenerative disorders and knowing their mode of action are of current interest. The present study was aimed to explore the effect of dietary supplement of Rasa-sindoor (RS), an organo-metallic derivative of mercury, on drug (MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced mouse model of Parkinson disease (PD). For this, mice were divided into three groups: (1) vehicle control (Normal saline treated), (2) Treated 1 (MPTP treated: 15mg/kg body weight, twice a day in 2 hours interval for 2 days, intraperitoneal injection) and (3) Treated 2 (MPTP: same as Treated 1 and Rasa Sindoor: 1gm/kg RS twice a day for 4 days). Total cellular RNA was extracted from sacrificed mice brain tissue and Immunohistochemistry (IHC) was performed for Tyrosine Hydroxylase (TH) in 100 µ section of mid-brain region to check dopaminergic neurodegeneration.  IHC revealed reduced TH activity in Treated 1 and Treated 2 as compared to vehicle control while Treated 2 showed greater TH activity than that of Treated 1. This preliminary observation was followed by a microarray based gene expression analysis, which results differential expression of a new set of genes involving neurogenesis, growth cone formation and axon guidance, activation of latent precursor cells etc.; validated by semi-quantitative real time PCR. Our result suggests that RS is neuroprotective and its mode of action may be through prevention of cell apoptosis and activation of latent precursor cells and cell growth.
Antibacterial activities of Melissa officinalis (Lamiaceae) aerial parts extracts against bacteria isolated from the oral microflora, and their antioxidant properties
Authors: Okmen Gulten , Guler Ayhan
Published: July 2024

Dental caries and periodontal diseases are common oral conditions associated with the formation of dental plaque. Dental plaque is composed of the oral microbiota and accumulates on the tooth surface. Despite the development of numerous antiseptic agents to control bacterial growth, the issue of bacterial resistance has prompted scientists to explore new avenues. As the problem of bacterial resistance continues to grow, studies in this field become increasingly crucial. Medicinal plants offer the best resources for this purpose, and Melissa officinalis L. is one such plant. This study aims to determine the antibacterial and antioxidant activities of Melissa officinalis against bacteria isolated from the oral microbiota. In the study, 8 bacteria were used as the organism source, and Melissa officinalis was utilized as the plant source. The extraction of the plant was carried out using ethanol, methanol, and water. All extracts were evaluated for their antibacterial activities using the disk diffusion method. Antioxidant activity studies were conducted using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. At the end of the study, the highest antibacterial activity was obtained from the ethanol extract of Melissa officinalis, with a 26 mm inhibition zone diameter against Staphylococcus epidermidis MBKK7. The highest antioxidant activity was determined to be 87.34% DPPH radical scavenging activity from the methanol extract of Melissa officinalis. As a result, it has been determined that Melissa officinalis exhibits both high antibacterial and antioxidant activities. It can be suggested that M. officinalis may serve as an effective natural protector against oral pathogens.
Pre-clinical study on hypo-testicular activity of hydro-ethanol (60:40) extract of Areca catechu (L.) in albino rat: Dose-dependent response
Authors: Hazra Sukriti , Pal Dibya , Das Puja , Mitra Dipanwita , Mondal Tanusree , Ghosh Debidas
Published: July 2024

The study focused to assess the dose-dependent hypo-testicular activity of hydro-ethanol seed extract of Areca catechu (10, 20 and 40 mg/ 100 g body weight) in albino rats. For this purpose, body weight, reproductive organo-somatic indices, as well as motility, count, hypo-osmotic swelling and acrosomal cap status of sperm along with the quantity of testicular androgenic key enzyme activities, serum testosterone, oxidative stress sensors, seminal vesicular fructose (SVF), apoptosis linked gene expression study and histology of testicular tissue for spermatokinetics were covered here. All the said doses revealed a significant (p<0.05) downward deviation in spermiological profile, serum testosterone, SVF levels, activities of testicular ∆5,3β and 17β-HSD, seminiferous tubular diameter compared to the vehicle-treated control (VTC). In contrast to the VTC, activities of superoxide dismutase and peroxidase were decreased along with elevation in the levels of thio-barbituric acid reactive substances significantly (p<0.05) in testis and sperm pellet of extract-treated groups. Testicular pro-apoptotic Bax gene expression was elevated and anti-apoptotic Bcl-2 gene expression was diminished significantly (p<0.05) after extract treatment compared to the VTC. Non-significant changes (p>0.05) were noted in hepatic acid and alkaline phosphatase activities which focused the non-toxic characteristics of said extract in general. This study interpreted that, 40 mg showed drastic hypo-testicular efficacy cum necrotic changes compared to other doses though the therapeutic dose that cross the borderline of fertile sensors from spermiological indicators is 20 mg dose. Liquid chromatography-mass spectrometry analysis of the said extract showed that ten phyto-molecules belong to flavonoid, alkaloid and isoflavone groups mainly.
Investigation of Tourist Satisfaction with the Public Transporation in Bali
Authors: Aryasih Putu Ayu , Ruhati Dessy , Puja Ida Bagus Putu , Darmiati Made , Widiana I Wayan , Mahendra Putu Ferry Krisna
Published: July 2024

Bali, a popular tourist destination in Indonesia, faces challenges from mass tourism, including ecological degradation and cultural changes. This study aims to examine Bali's transportation system using a mixed-method approach. Qualitative data from field observations and interviews were combined with quantitative data on transportation quality. Qualitative findings highlighted issues such as traffic congestion, while quantitative data revealed specific numbers on passenger satisfaction levels. Integrating both methods provided a comprehensive understanding of Bali's transportation landscape. The study emphasizes the role of technology in improving public transit services and enhancing tourist experiences. The implications include the importance of sustainable tourism planning and infrastructure development in addressing transportation issues in Bali.
Sokak Köpeği Sahiplenme Deneyimlerini Görünür Kılmak: Özel Olan Politiktir
Authors: Özdoğan Huri Kiraz
Published: July 2024

Bu makalede iktidar kurumlarının sokak köpeği olgusunu sahiplendirmeyle yönetme politikasını sorunsallaştırıyorum. Politik, toplumsal ve ekonomik boyutları olan bir konuyu kamusal alanın sorumluluğundan özel alandaki kişilerin sorumluluğuna taşıyarak görünmezleştirdiklerini iddia ediyorum. Feminist hareketin “özel olan politiktir” mottosundan hareketle sokak köpeği sahiplenenlerin deneyimlerine odaklanarak bunları görünür kılıyorum. İlkin Köpek Nüfus Yönetimi Paradigmasının düzenlediği –bakımevi, toplama gibi– araçlarında ve düzenleme dışı bıraktığı müşterek yaşam alanlarda ötekileştirilmelerini ve metalaştırılmalarının travma yaratan yönlerini deneyimler üzerinden gösteriyorum. Sahiplenilen köpeklerin yaşanmışlıklarını yeni sahipli yaşamlarına da taşıdıklarına dikkat çekiyorum. Sahiplenenlerin de hiçbir kamu desteği almaksızın kendi olanaklarıyla travmaları iyileştirme ve/veya onları idare etme yönünde geliştirdikleri yöntemleri aktarıyorum. Bu süreçte sosyal çevrelerinde ve müşterek alanlarda ötekileştirilebildiklerine de dikkat çekiyorum. Kamunun bu alanda öncelikle köpeklere tekil bakacak ve onları ötekileştirmeyecek şekilde paradigmasını değiştirmesine dair vurguyu paylaşıyorum. Burada aynı zamanda sahiplendirmeyle ilgili düzenlemelerin patriarkal eşitsizlikleri pekiştirmeyip bilakis onları dönüştürecek şekilde olmasına dair taleplere de yer veriyorum.
Kötü Huylu Sorunlar Bağlamında Türkiye'de Sokakta Yaşayan Hayvanlar: Eleştirel Halkla İlişkiler Perspektifinden Bir Çerçeve
Authors: Göncü Barika
Published: July 2024

Bu çalışmanın amacı, öncelikle sosyal planlama alanında kavramsallaştırılan ve sonrasında farklı alanlarda tartışılan “kötü huylu sorunlar” bağlamında Türkiye’de sokakta yaşayan hayvanların ve bu alanda çalışan sivil toplum inisiyatifleri ve gönüllüler ile, bu alanı “yöneten” merkezi hükümet ve yerel yönetim birimlerinin etkileşimleri sonucu ortaya çıkan sorunları tarif ederek; halkla ilişkiler disiplininin bu sorunlu alana ne yönde olumlu katkı sağlayabileceğine dair bir çerçeve önermektir. Çalışmada, kötü huylu sorunlar ve eleştirel halkla ilişkiler literatürlerinden, ayrıca yazarın hayvan hakları alanındaki bireysel deneyimlerinden yararlanılmıştır. Bu çalışma hem geleneksel hem de eleştirel halkla ilişkiler literatüründe hayvanlarla ilgili çok az sayıdaki çalışmaya Türkiye’nin özgün koşullarını da ortaya koyarak katkıda bulunmaktadır. Çalışmada Türkiye’de sokakta yaşayan hayvanların ve bu hayvanların haklarını savunan sivil inisiyatiflere ve gönüllülere olduğu kadar, halkla ilişkiler uygulayıcılarına da ilham olabilecek bir çerçeve sunulmaktadır.
Hayvanların Hakları
Authors: Brophy Brigid , Güçlü Özlem
Published: July 2024

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Bir Kahramanın Ardından: Burak Özgüner Hayvan Hakları Çalışma Merkezi (BurHak)
Authors: Özmen Cansu Özge
Published: July 2024

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Caso nº 12.066 - Trabalhadores da Fazenda Brasil Verde vs Brasil: as ações do Brasil para o cumprimento de sentença internacional
Authors: Da Silva Luciana Rodrigues Chaves , Pereira Airton Dos Reis
Published: July 2024

O presente artigo tem por objetivo apresentar a problemática do trabalho escravo a partir das reflexões sobre o “Caso nº12.066, Trabalhadores da Fazenda Brasil Verde vs. Brasil”, decisão da Corte Interamericana de Direitos Humanos (Corte IDH) condenou o Estado brasileiro, em outubro de 2016, pela prática de trabalho escravo, entre 1989 e 2000, na Fazenda Brasil Verde, no sul do Pará. O Relatório da Corte IDH descreve os fatos ocorridos na Fazenda Brasil Verde, propriedade de João Luiz Quagliato Neto e a inercia do Estado brasileiro em investigar e punir os responsáveis. Relata ainda o desrespeito do Brasil aos direitos fundamentais resguardados em leis, tratados internacionais e na própria Constituição. Através de pesquisa documental e bibliográfica, será apresentado o conceito de dignidade da pessoa humana e como o trabalho escravo é capaz de suprimir o direito fundamental a ser reconhecido como pessoa. Será ainda realizado uma descrição do acompanhamento de sentença internacional, e como o Brasil tem cumprido as determinações da Corte IDH.
Patrimônio cultural da Amazônia mosqueirense e História no Novo Ensino Médio
Authors: Tavares Daniel Rodrigues
Published: July 2024

Este texto se propõe a entrelaçar Patrimônio Cultural, História e seu ensino e o Novo Ensino Médio. Debate o conceito de Patrimônio no Brasil, pensando-o como pode ser problematizado pela História e utilizado no ensino, dentro do formato do Ensino Médio, reformulado a partir da lei 13.415/2017. O locus da pesquisa é o distrito de Mosqueiro, que integra o território de Belém, capital do Pará. É uma parte da Amazônia Oriental, a qual denominamos “Amazônia Mosqueirense”. Trata-se de um artigo que apresenta a possibilidade de usar os bens culturais, por meio da Educação Patrimonial, no ensino de História, diante de um currículo do Novo Ensino Médio, que pouco evidencia a cultura e o patrimônio locais. Para tanto, compreendemos Patrimônio Cultural como um objeto de pesquisa da História, como fonte histórica, como recurso pedagógico e como elo de memória e identidade entre passado, presente e futuro.
Utilization of Solar Panel Technology to Save Electricity Costs in Fish Farm Irrigation
Authors: Nisrina Safira Fegi , Mudzakir Mohammad Alfian , Rahmat Basuki
Published: July 2024

Solar panels are a medium that can convert solar energy into electrical energy. In this research, the solar panel system in the fish pond is used as air requirements for the survival of the fish so that the air supply is sufficient. The problem is that fish farming has cloudy water due to decreasing temperatures due to lack of irrigation. This condition really requires water flow using a pump to circulate water in the fish pond. Therefore, solar panels are needed to drive the water circulation pump, where these solar panels are an alternative energy source to replace electricity from the State Electricity Company (PLN).The purpose of using a solar panel system is as alternative energy that can supply a pump motor which functions to channel water from the well to the pond to keep it flowing. This is used as alternative electrical energy to replace energy sources originating from the State Electricity Company (PLN) and to reduce operational costs of electrical energy. The method used is to assemble and install 2 units of 100WP solar panels, then testing is carried out to measure the panel output power from 06.00 to 17.00. The average result of measuring solar panel power every 30 minutes is 24.48Watts per day, this condition was when the test was carried out when the weather was less sunny. However, this can still change to get maximum power depending on weather conditions, especially when the sun is hot.
Analytical Hierarchy Process Method to Determine Student Satisfaction Level with Academic Services
Authors: Saka Gilang Armawan , Hasugian Abdul Halim
Published: July 2024

Student satisfaction is an important aspect in the world of higher education that must be taken seriously. This is because students are the main stakeholders in the learning process and the development of educational institutions. The purpose of this research is to identify factors that affect student satisfaction with academic services and to apply the AHP method in determining the relative weight of each assessment factor that affects student satisfaction with academic services. The results showed that the AHP method helped weight alternatives and criteria with a weight scale of 1 - 9 according to the Saaty table, after weighting the alternatives, then ranking using the AHP method to get the final score, ranking 1 was obtained by Conducive Lecture Room with a final score of 0.084 and ranking 21 was obtained by Regulation with a final score of 0.037, therefore the level of student satisfaction with Conducive Lecture Room was the highest. The design of the application is carried out by conducting research in the academic science of UINSU by collecting student assessment data on academic services, after the data is collected, the weighting of each academic service is carried out and then entered into the application that has been built using the AHP method, influencing factors based on the weight of criteria and sub-criteria.
User-Centered Design Approach in Developing User Interface and User Experience of Sculptify Mobile Application
Authors: Dananjaya Md. Wira Putra , Prathama Gede Humaswara , Darmaastawan Kadek
Published: July 2024

In the increasingly digital era, user interface (UI) and user experience (UX) design have become crucial factors in application development. The success of an application is not only determined by its functionality, but also by how well users can interact with the application. User Centered Design (UCD) is an approach that places users as the main focus in every stage of design, from initial research to final evaluation, to ensure that the resulting product truly meets user needs and expectations. This study applies the UCD approach to the UI and UX design of the Sculptify application, which is designed to facilitate the buying and selling of sculptures and other three-dimensional works of art. Given the complexity and uniqueness of art product transactions, effective UI and UX design is very important. This study involves the active participation of potential users through methods such as interviews, surveys, and usability testing to create an intuitive interface and provide a satisfying experience for users. The research stage begins with research to understand user needs and preferences, followed by initial design and a series of tests and iterations based on user feedback. The final evaluation is carried out to measure the extent to which the final design meets user needs and expectations. The results of the UCD implementation are expected to provide valuable insights into the importance of placing users at the center of the design process and how this can improve the quality of interactions and overall user satisfaction.
Analysis of Students’ Understanding Concepts on Algebra Topics Reviewed from Students’ Attitude Toward Mathematics
Authors: Jayadi Muhammad Irawan , Pramudya Ikrar , Nurhasanah Farida
Published: July 2024

This research discusses how students’ abilities to understand mathematical concepts are grouped into three types of students’ attitudes toward mathematics. Three types of student attitudes were obtained using a questionnaire which then obtained positive, neutral, and negative attitudes towards mathematics. This research aims to find out how students’ ability to understand concepts with positive, neutral, and negative attitudes towards mathematics. The form of research used is qualitative descriptive research because it prioritizes process rather than results. Students are given test questions and interviews are conducted to validate the validity of the student test result data. The indicators for understanding the concept used in this research are 7 indicators. This research shows that students with positive attitudes toward mathematics fulfill 6 indicators of the 7 indicators of conceptual understanding used in this research. Students with a neutral attitude towards mathematics can fulfill 5 of the 7 indicators of understanding the concept. Students with negative attitudes are only able to understand 1 indicator and tend to be lazy when taking tests.
Students’ Evaluation of Learning Outcomes for Quality Assurance in the Teaching Process at Mountains of the Moon University, Fort Portal, Uganda in East Africa
Authors: Katende David
Published: July 2024

This study employed a mixed-method approach, with a predominance of quantitative analysis to probed user relevance of students’ evaluation of course learning outcomes for quality assurance in the teaching process at Mountains of the Moon University. Self-Administered online Questionnaires with kobo toolbox were used to specifically answer the following question: What is the relevance of students’ evaluation of course learning outcomes (problem solving skills, critical thinking skills, leadership skills, effective communication), as an aspect of quality teaching at Mountains of the Moon University? The study employed a case study design and respondents comprised of 170 undergraduate students in both second and third year and 13 post graduate students at least in their second semester of study. Collected data using online questionnaires with KoBo tool box and documentary review, were analyzed using SPSS. Findings confirm the reliability of SETs as tools for quality assurance in teaching, highlighting the importance of focusing on learning outcomes and quantifiable performance indicators to develop effective SET tools. Designing of Teaching and learning assessment tools has to be guided by clear objectives developed by the Bloom Taxonomy action verbs; that should be used in designing appropriate learning outcomes. The insights emphasize that good teaching should focus on appropriate learning outcomes and that SETs are reliable tools for measuring teaching quality in higher education. Quantifiable performance indicators are essential for developing effective SET tools, aligning with quality assurance policies. The study recommends that, regulatory bodies should benchmark with the findings in this study as a basis for building candid evaluation of teaching guidelines for Higher Education Institutions.
BURNOUT EM DOCENTES DO ENSINO SUPERIOR PORTUGUÊS
Authors: Sanches Alexandre , Crespo Diogo , Durão Mário
Published: July 2024

Este estudo investiga a prevalência da síndrome de burnout e características associadas entre professores do ensino superior em Portugal. A amostra é constituída por 19 professores do ensino superior. O estudo adota uma abordagem quantitativa, tendo por instrumento o Maslach Burnout Inventory – Educators Survey (MBI-ES) para medir as dimensões de exaustão emocional (EE), despersonalização (DP) e realização pessoal (RP). A análise descritiva revelou uma predominância de níveis baixos de EE e DP, e níveis moderados de RP entre os participantes. As análises estatísticas inferenciais exploraram a relação entre burnout e variáveis demográficas, como idade, sexo e o tipo de instituição de ensino (pública e privada). Os resultados indicam que o burnout é significativamente influenciado pelo ambiente organizacional, com professores em instituições privadas a apresentar níveis mais elevados de exaustão emocional comparativamente aos seus pares em instituições públicas. Reforça-se a importância de estratégias de intervenção que integrem apoio psicológico e reformas organizacionais para prevenir e mitigar o burnout.
Management of refractory hepatic hydrothorax: a report of two cases and review of the literature
Authors: Calixto-Aguilar Lesly , Díaz Ferrer Javier
Published: July 2024

Hepatic hydrothorax is a transudative pleural effusion in patients with cirrhosis. A 56-yearold cirrhotic patient presented with dyspnea and desaturation; his chest images showed a right pleural effusion. Another 66-year-old woman with cirrhosis, developed during her hospitalization acute respiratory failure, and her chest X- ray showed left pleural effusion. Initially, both patients were prescribed a dietary sodium restriction and diuretics. Nevertheless, they didn’t have a good response so a chest tube was placed, and an octreotide infusion partially reduced the volume of the pleural drainage allowing a pleurodesis. We report two cases of refractory hepatic hydrothorax with multiple treatments including octreotide and pleurodesis.
Enfermedad vascular porto sinusoidal: una causa inusual de sangrado digestivo
Authors: Yance Stalin , Montes Pedro , Arevalo Fernando
Published: July 2024

La hipertensión portal (HTP) se define como el aumento de la presión a nivel de la vena porta por encima de 5 mmHg, siendo la causa más frecuente la cirrosis hepática. Dentro de las causas intrahepáticas presinusoidales de HTP con compromiso venular portal se describe a la que tradicionalmente fue conocida como hipertensión portal no cirrótica idiopática (HPNCI) teniendo como requisitos excluir aquellos pacientes que no presentaban HTP, así como aquellos con presencia de cirrosis hepática y trombosis venosa portal (TVP). Actualmente se han replanteado los criterios diagnósticos de esta entidad, y su denominación, siendo conocida como enfermedad vascular porto sinusoidal (EVPS) además no excluye a los pacientes con HTP o presencia de enfermedad hepática de base. La biopsia hepática continúa siendo el gold estándar para su diagnóstico. Las manifestaciones clínicas son derivadas de la HTP y el manejo es similar a las complicaciones que se presentan como en los pacientes con cirrosis hepática. Se presenta el caso de un paciente varón quien debuta con cuadro de sangrado digestivo, con hallazgos de varices esofágicas en la endoscopia alta además de estudio de hepatopatía viral, autoinmune y de depósitos negativos, con biopsia hepática concluyente de Enfermedad vascular portosinusoidal.
Irritable bowel syndrome in medical students from Lima, Peru, during the COVID-19 pandemic, using virtual questionnaires according to the Rome IV criteria: prevalence and associated factors
Authors: Medina-Pérez Roberto , Chavarria-Ocmin Rubbens , Espinoza-Ríos Jorge , Samalvides-Cuba Frine
Published: July 2024

Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder, characterized bychanges of the intestinal habit associated with abdominal pain. This study analyzed factorsassociated with this pathology during the COVID-19 pandemic, and it was seen that the impact of IBS was higher in young women who had ongoing studies in the medical field. Objectives: Determine the prevalence of IBS in medical students and explore the associated factors with the increase of its symptoms, through the use of digital tools. Materials and methods: Descriptive observational study with exploration of associations, with nonprobabilistic sampling, until reaching the minimum sample of 110 participants with a confidence interval of 95%, finally having a total sample of 131 students, distributed in 3 proportional and representative subgroups of the last 3 years of study of the medical career from a university from Lima, Peru. The inclusion criteria were students of both sexes and legal age, who gave their consent to participate and did not have risk factors for GI disease. Once the study was approved, the link of a validated virtual questionnaire was shared through the institutional email. To explore the associated factors, the Chi-square test was used with a statistical significance of p < 0.05. Results: Responses were obtainedfrom 195 students; 64 (32.82%) of them had at least one exclusion criteria, finally having a sample size of 131; 64 (48.85%) were women, and 52 (39.69%) were from 7th year. Using the Rome IV criteria, 23 participants were classified as having IBS, which indicates a prevalence of 17.56%, 14 (60.87%) of them were women and 10 (43.48%) were from the 7th year (last year of study of the medical career in Peru). It was observed that 1 in 3 students (32.06%) had chronic abdominal pain, and 1 in 2 (53.44%) reported having a history of Major Depression or Generalized Anxiety Disorder. Of the total, 51 (38.93%) had a history of having a positive COVID-19 test result. Regarding the associated factors, a significant association was only found between IBS and the diarrhea type, classified according to the Bristol Scale. Conclusions: The prevalence of IBS in medical students was 17.56%, the highest compared with studies in the general population and in medical students using Rome IV criteria. Of the associated factors, the clinical presentation of diarrhea, according to the Bristol scale, was associated with IBS.
The Impact of Social Media on Language Evolution
Authors: Dembe Tony
Published: July 2024

Purpose: The general purpose of this study was to explore the impact of social media on language evolution.
Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings reveal that there exists a contextual and methodological gap relating to the impact of social media on language evolution. Preliminary empirical review revealed significant changes in language use driven by the rapid spread of new words, phrases, and communication styles on social media platforms. It found that social media democratized language change, allowing diverse users to influence linguistic trends, and highlighted the emergence of micro-languages within online communities. The integration of visual elements like emojis and memes into text-based communication added nuance and expressiveness, aligning digital interactions more closely with face-to-face communication. The study emphasized the need for digital literacy in education and ongoing research into digital communication's impact on language, noting social media's role as a powerful catalyst for language change.
Unique Contribution to Theory, Practice and Policy: The Social Network Theory, Diffusion of Innovations Theory and Speech Community Theory may be used to anchor future studies on social media on language evolution. The study recommended expanding traditional linguistic theories to incorporate the dynamics of digital communication, incorporating digital literacy into education to prepare students for new linguistic norms, and for businesses to align their messaging with emerging social media trends. It also advised policymakers to use social media for language preservation, bridge the digital divide to promote linguistic diversity, and support interdisciplinary research to understand the long-term effects of social media on language. These recommendations aimed to adapt theory, practice, and policy to the evolving linguistic landscape.
The Role of Phonological Awareness in Early Reading Development
Authors: Nkurunziza Sheila
Published: July 2024

Purpose: This study sought to investigate the role of phonological awareness in early reading development.
Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings reveal that there exists a contextual and methodological gap relating to phonological awareness in early reading development. Preliminary empirical review revealed that phonological awareness was crucial for early reading development, serving as a foundation for decoding skills and overall literacy. It emphasized the importance of early, systematic instruction in phonological awareness within early childhood education to improve reading outcomes and reduce reading difficulties. The study highlighted that phonological awareness also contributed to spelling and vocabulary development, enhancing overall language proficiency. It advocated for integrated and inclusive educational strategies that consider diverse linguistic and cultural contexts to bridge literacy gaps and promote equitable learning opportunities for all children.
Unique Contribution to Theory, Practice and Policy: The Phonological Deficit Hypothesis, Simple View of Reading and the Emergent Literacy Theory may be used to anchor future studies on the role of phonological awareness in early reading development. The study recommended further exploration into the multifaceted nature of phonological awareness to advance theoretical models and emphasized the need for early, systematic, and engaging phonological awareness instruction in early childhood education. It called for individualized interventions for at-risk children, ongoing teacher professional development, and frequent monitoring of progress. The study also urged policymakers to invest in early literacy programs, ensure equitable access to educational resources, and include phonological awareness assessments in screening programs. Additionally, it advocated for increased collaboration between researchers, educators, and policymakers to create a cohesive approach to early literacy education.
Efficacy of Yoga Interventions in Alleviating Physician Burnout: A Review of Randomized Controlled Trials
Authors: Giridharan Selvaraj , Ziff Charlotte
Published: July 2024

Background: Physician burnout has become a significant concern in the medical community. It is characterized by  emotional exhaustion, depersonalization, and a reduced sense of personal accomplishment. Considering physicians’  unique challenges, there is an increasing interest in exploring holistic interventions such as yoga, which may benefit  stress management and overall well-being. Methods: We conducted a comprehensive analysis of randomised controlled trials published between 2014 and  2023, assessing the impact of yoga interventions on physician burnout across various databases. Results: Our analysis uncovered five randomized trials demonstrating that yoga can effectively alleviate symptoms  of physician burnout, such as depersonalization and emotional exhaustion. Furthermore, yoga has been shown to  improve professional fulfillment, flexibility, and overall well-being. These advantages extend beyond stress relief  and encompass various aspects of professional life. Conclusion: Yoga interventions can alleviate physician burnout by targeting physical, emotional, and mental health  factors. According to the findings, incorporating yoga-based wellness programs in health-care settings can promote  physician well-being, enhance job satisfaction, and improve patient care. Additional research is required to strengthen  the evidence base and facilitate the implementation of customized yoga interventions in the medical profession. Burnout is a well-established occupational syndrome with significant  implications for various professions, particularly in the medical field.[1] It is a complex phenomenon characterized by emotional exhaustion,  depersonalization, and reduced personal accomplishment due to  chronic occupational stress.[2] While burnout is not officially classified  as a medical condition, it has been linked to mental illness and can  have severe consequences for individuals and organizations. It is a  multidimensional occupational phenomenon that can affect individuals  in various contexts, as demonstrated by studies on parental burnout and  burnout among university students during the COVID-19 pandemic.[3-5]