bluuebunny/crossref_metadata_2025 huggingface dataset:
SGLT2i alleviates epicardial adipose tissue inflammation by modulating ketone body–glyceraldehyde-3-phosphate dehydrogenase malonylation pathway
Authors: Li Lina , Hua Cuncun , Liu Xiaoyan , Wang Yidan , Zhao Lei , Zhang Yeping , Wang Li , Su Pixiong , Yang Min-Fu , Xie Boqia
Published: March 2023

Aims

Inflammation in the epicardial adipose tissue (EAT) is a contributor to atrial fibrillation. Studies have reported that sodium glucose co-transporter 2 inhibitor (SGLT2i) can alleviate EAT inflammation. However, the mechanism remains elusive. This study aims to investigate the molecular mechanism of SGLT2i in reducing EAT inflammation and to explore the effects of SGLT2i on atrial fibrosis in atrial fibrillation.

Methods

Sprague–Dawley rats were injected with angiotensin II to induce atrial fibrillation and randomly assigned to receive SGLT2i (n = 6) or vehicle (n = 6). Macrophages (RAW264.7) were treated with ketone bodies; ACC1 knockdown/overexpression and malonyl-CoA overexpression were performed in vitro. The levels of inflammatory cytokines, ACC1, and malonyl-CoA were examined by ELISA. GAPDH malonylation was measured by co-immunoprecipitation.

Results

In atrial fibrillation rats, SGLT2i increased the ketone body levels and decreased the expression of ACC1 and alleviated EAT inflammation and atrial fibrosis. In RAW264.7 cells, ketone bodies decreased the levels of ACC1, malonyl-CoA, and GAPDH malonylation, accompanied by reduced inflammatory cytokines. ACC1 knockdown decreased the expression of malonyl-CoA and GAPDH malonylation and alleviated lipopolysaccharide (LPS)-induced macrophage inflammation; these effects were inhibited by malonyl-CoA overexpression. Furthermore, the protective effects of ketone bodies on macrophage inflammation were abrogated by ACC1 overexpression.

Conclusion

SGLT2i alleviates EAT inflammation by reducing GAPDH malonylation via downregulating the expression of ACC1 through increasing ketone bodies, thus attenuating atrial fibrosis.
Ушел из жизни профессор Геннадий Петрович Жуков
Authors: Editorial Article
Published: March 2023

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Comparative analysis of the legal status of migrant workers on SES Agreement on the Legal Status of Migrant Workers and Members of Their Families and the Treaty on the Eurasian Economic Union
Authors: Davletgildeev Rustem Sh. , Sycheva Olga V.
Published: March 2023

The present article is devoted to the analysis of the Agreement on the Legal Status of Migrant Workers and Members of Their Families, signed in St. Petersburg in 2010 in comparison with the recently signed Treaty on the Eurasian Economic Union. The subject of analysis is the legal regime for migrant workers from the states of the Common Economic Space, acting on the territory of the Russian Federation. The analysis of the legal regime is performed based on its speciﬁ city: the features of employment of migrant workers; conditions of temporary stay; registration procedures; measure of migrants labor rights, and other rights that apply including family members of migrant workers; taxation of migrant workers income. Concludes that there is a special regime for migrant workers from the Republic of Belarus and the Republic of Kazakhstan.
The Influence of Online Format on Forming Soft Skills in Foreign Language Teaching
Authors: Vorontsova M. V. , Klyukina E. V. , Ziza M. V.
Published: March 2023

The purpose of this research is to identify opportunities to develop soft skills, which are essential for graduates’ future professional activities, in online foreign language learning. The study focuses on distance learning, which has become a reality in university education due to the pandemic and the increased availability of higher education to those who cannot attend in-person classes (because of the distance, health problems, etc). Specifically, the research aims to demonstrate which soft skills, prioritized by employers, can and must be developed in distance foreign language learning, the preferred typology of exercises for this task, the specifics of teachers’ work in this format, and how to mobilize active attention in distance education. The study uses survey results collected from teachers and students at Lomonosov Moscow State University, which are analyzed along with relevant theoretical models. The research prioritizes tasks and assignments targeting soft skills such as creativity, learnability, critical thinking, and collaboration, with independent student work gaining more importance. The study concludes that online lessons should emphasize autonomous work performance over primary educational elements, and the results can form the basis for developing foreign language methodology in distance instruction. The research suggests this could be an optional module in a hybrid format that shows promise for higher foreign language education.
Der Gehülfe - (Erstdruck)
Authors: Walser Robert
Published: March 2023

Robert Walsers zweiter Roman Robert Walsers zweiter Roman Der Gehülfe wurde 1908 vom Verlag Bruno Cassirer in Berlin verlegt, in dem 1907 bereits Geschwister Tanner erschienen war. Die Kritische Robert Walser-Edition dokumentiert erstmals den Textstand des Erstdrucks des Romans, über den Christian Morgenstern, der Lektor des Verlags, urteilt: «Walser gefällt mir ausgezeichnet. [… ] Es ist etwas breit gewebt, aber die Muster verblüffen immer wieder durch ihre Feinheit. Eine erstaunliche Zucht und Reife erhebt es künstlerisch weit über die Vorgänger.» Die Entstehungs- und Textgeschichte des Romans gibt dabei einige Rätsel auf. Morgenstern lag noch vor dem Erscheinen von Geschwister Tanner, im November 1906, ein neues Manuskript Walsers vor, das in der überlieferten Korrespondenz mit «Gehülfe» betitelt wird, sich aber inhaltlich wesentlich vom vorliegenden Roman unterschieden haben muss. Offenbar wurden also binnen eines Jahres zwei Manuskripte fertiggestellt, wovon aber nur eines zum Druck gelangte. Im Nachwort der KWA werden diese nur lückenhaft zu rekonstruierende Entstehungsgeschichte Des Gehülfen und die dazu erhaltenen Dokumente in Auszügen wiedergegeben. Ein Abriss der frühen Rezeption gibt einen Einblick in die teilweise kontroversen Besprechungen und das breite Echo der Kritik zu Robert Walsers zweitem publizierten Roman. Im philologischen Apparat der Edition wird die Textdifferenz der Buchausgabe gegenüber der Handschrift (KWA IV.2) dargestellt. Die in KWA IV.2 faksimilierte und diplomatisch transkribierte Handschrift ist das einzige erhaltene Romanmanuskript neben demjenigen zu Geschwister Tanner. Die Entstehung des Romans scheint problemlos und rasch vonstatten gegangen zu sein, wie durch Selbstaussagen Walsers gegenüber Carl Seelig und in einem späteren Prosastück nahegelegt wird, worin dem Erzähler «in recht kurzer Zeit ein Roman aus der Feder hervorsproß». Im Vergleich zum ersten Roman weist das Manuskript auch ungleich weniger Bearbeitungsspuren auf. Der gleichmässige und saubere Schriftduktus lassen den Eindruck einer Abschrift entstehen. An den Faksimiles nachvollziehbare handschriftliche Phänomene legen jedoch nahe, dass es sich auch hier um eine Erstniederschrift handelt, die Walser vermutlich in der zweiten Jahreshälfte 1907 angefertigt hat. Auf der beigelegten DVD befindet sich die elektronische Version aller bisher in der KWA edierten Bände, mit Dokumenten und den farbig Handschriftenfaksimiles. Ausserdem enthält die DVD die fortlaufend aktualisierte Version des Findbuchs, mit dem sämtliche Texte Robert Walsers nach den Archivstandorten, Erstdruckorten und den Abdrucken in den wichtigsten späteren Textausgaben identifiziert werden können.
Geschwister Tanner - (Manuskript)
Authors: Walser Robert
Published: March 2023

Als erste Bände erscheinen der kritisch edierte und philologisch kommentierte Erstdruck und die Faksimile-Edition des bisher unpublizierten Manuskripts von «Geschwister Tanner», Robert Walsers Debüt als Romanschriftsteller. Die in KWA IV.1 faksimilierte und diplomatisch transkribierte Handschrift ist die früheste erhaltene Druckvorlage in Walsers Nachlass. Allem Anschein nach stellt das Manuskript, niedergeschrieben im Januar 1906 in Berlin, zugleich auch die erste Niederschrift des Romans dar; Vorentwürfe sind keine bekannt. Christian Morgenstern, damals tätig als Lektor beim Verlag Bruno Cassirer, berichtet dem Verleger am 8. April 1906 von der Lektüre des Manuskripts: «Bis zur Mitte der ‹Geschwister Tanner› sagte ich mir: du hast selten etwas in seiner Art so Schönes gelesen. Im Verlauf des 2. Teils wurde ich manchmal von einer leisen Ungeduld ergriffen, obwohl auch er herrliche Stellen enthält.» Das Manuskript zu «Geschwister Tanner», das im Vergleich zu vielen anderen Handschriften Walsers ein ungewöhnlich hohes Mass an Bearbeitungsspuren aufweist, gibt einen neuen und differenzierten Einblick in die Anfänge von Walsers schriftstellerischer Entwicklung und dokumentiert indirekt auch die Auswirkungen des Lektorats von Bruno Cassirer und Christian Morgenstern. Ein vollständiges Variantenverzeichnis teilt die Textveränderungen mit, die der Wortlaut des Manuskripts auf dem Weg zum Erstdruck erfahren hat. Christian Morgenstern, der auch noch die ersten Korrekturfahnen des Romans mitgelesen hat, schrieb an Walser im September 1906: «Der Anfang Ihrer Arbeit machte auf mich, aus dem Privatgebiet des Handschriftlichen in die Öffentlichkeit des Drucks gerückt, einen schlechten Eindruck.» Die Edition des Erstdrucks (KWA I.2) enthält in zahlreichen philologischen Annotationen Hinweise zur Textdifferenz des Erstdrucks gegenüber der Handschrift und gibt im Nachwort einen Abriss der frühen Rezeption des Romans. Auf der beigelegten CD-ROM befindet sich die elektronische Version der «Geschwister Tanner»-Edition, mit Dokumenten und den farbigen Handschriftenfaksimiles. Ausserdem enthält die CD-ROM die erste Version des «Findbuchs», mit dem sämtliche Texte Robert Walsers nach den Archivstandorten, Erstdruckorten und den Abdrucken in den wichtigsten späteren Textausgaben identifiziert werden können.
Prinzipien gelingender Gouvernanz - Lehren aus 40 Jahren diplomatischer Tätigkeit
Authors: Gyger Walter B.
Published: March 2023

Wenn Frieden und Wohlstand längerfristig erhalten werden sollen, muss das egoistische, insulare Denken überwunden werden. Es ist keine Zeit mehr zu verlieren, um das regelbasierte internationale System zu stärken, mit dem Ziel, den Frieden zu erhalten, den Wohlstand für alle zu fördern, die Achtung der Menschenrechte zu sichern und die Erhaltung der natürlichen Lebensgrundlagen zu gewährleisten. Wenn aus den Fehlern der Vergangenheit nichts gelernt wird, wird sich die Menschheit womöglich mit dem nächsten grossen Krieg selbst zerstören. Niemand soll später sagen: Ich habe nichts gewusst und konnte nichts tun.
Dieses Buch bietet Einblicke und Lehren, wie gelingende Gouvernanz die Welt vom Abgrund wegführen kann, vor dem die Menschheit heute steht.
Das Manifest der Toleranz
- Über Ketzer und ob man sie verfolgen soll; De haereticis an sint persequendi. Mit Beiträgen von Stefan Zweig, Hans R. Guggisberg und Uwe Plath. Herausgegeben und mit einer Einführung von Wolfgang F. Stammler
Authors: Castellio Sebastian
Published: March 2023

Sebastian Castellios De haereticis an sint persequendi aus dem Jahr 1554 hat die Geschichte der Toleranz und des Kampfes um Gedanken- und Glaubensfreiheit maßgeblich beeinflusst: Eindringlich werden darin die Mächtigen jener Zeit ermahnt, Andersdenkende nicht zu verfolgen und zu töten. Das bis heute aktuelle Werk liegt mit der vorliegenden Ausgabe erstmals vollständig auf Deutsch übersetzt vor. Ebenfalls in deutscher Übersetzung enthält das Buch die vermutlich von Castellio unmittelbar zuvor verfasste Historia de morte Serveti sowie seine dem Basler Rat vorgelegte Verteidigungsschrift. Umrahmt werden Castellios Schriften durch den Abdruck von Stefan Zweigs Einleitung zu seiner historischen Monographie «Castellio gegen Calvin» (Wien 1936) und von den zwei Kapiteln zu De haereticis, die Hans Rudolf Guggisberg in der Biographie «Sebastian Castellio, 1515–1563» (Göttingen 1997) publizierte.
Fotografie als Archiv der Zukunft
Authors: Ebner Nina Victoria
Published: March 2023

Die Frage nach der Zukunft einer Gesellschaft stellt sich die Menschheit seit Anbeginn; sie vorhersehen zu können, zu beeinflussen und mitzugestalten erscheint als Antrieb der Bewältigung der Gegenwart. Gerade in Zeiten der Krise, die im 21. Jahrhundert unweigerlich globale Prozesse mitbestimmt, richtet sich der Blick auf kreative Praktiken, die sich mit dem Ungreifbaren und Kommenden beschäftigen. Zu ihnen zählen afrikanische und afrodiasporische Futurismen in den Künsten, die in Form von Utopien und Dystopien gesellschaftliches Miteinander diskutieren, das in der Zukunft Realität werden könnte.Ein prominenter Schauplatz dieser Aushandlungen ist die Fotografie. Dabei bieten die medialen Strukturen einen Zusammenschluss zweier widersprüchlicher Positionen: Der dokumentarisch-archivarische Zweck des Fotos wird ergänzt, indem die Zukunft in Bilder gefasst wird, bevor sie eintreten kann. Schlüsselmomente des Mediums sind dabei die Konservierung und Inszenierung des Flüchtigen, Alltäglichen und Widerständischen (Campt 2017; 2021) in einer inszenierten Reglosigkeit und Singularität einzelner Aufnahmen. Die These ist es, dass diese Grundbedingungen der Fotografie die Darstellung von Zukünftigkeit (Futurity) begünstigen, indem sich Fotograf:innen der medialen Charakteristika und Grenzen bedienen, sie ausstellen und durch neue Bildentwürfe eine Erweiterung des Archivwissens der Zukunft anstreben. Anhand einer theoretischen Annäherung an die fotografische Praxis und aktuelle Entwicklungen afrikanischer und afrodiasporischer Futurismen wird die Feststellung im Folgenden mit Rückbezug auf Positionen der (Postcolonial) Cultural Studies erörtert.
PARASITIC CONTAMINATION OF FRUIT AND BERRY PRODUCTS OF THE ASTRAKHAN REGION
Authors:   Center for Hygiene and Epidemiology in the Astrakhan region, Astrakhan, Russian Federation, SHEMETOVA S.A. , ARAKELYAN R.S. ,   Department of Infectious Diseases and Epidemiology, Astrakhan State Medical University, SHENDO G.L. ,   Center for Hygiene and Epidemiology in the Astrakhan region, Astrakhan, Russian Federation, IRDEEVA V.A. ,   Clinical Maternity Hospital named after Yu. A. Paskhalova
Published: March 2023

Objective: To study and analyse the parasitic contamination of fruit and berry products of the Astrakhan region. Methods: 7776 studies were carried out using 4792 samples of food products. In the structure of all food products, the share of fruit and berry products was 8.9% (n=267), of which 3.4% (n=9) did not correspond to the norm. Results: The percentage of fruit samples that failed to meet parasitological parameters was 1.9% (n=2); in these samples, immobile larvae of Strongyloides stercoralis were found. In addition, samples of 13 berry fruit species were examined for the presence of parasites (5.3%, n=159). The percentage of suboptimal samples was 4.4% (n=7), in these samples dead larvae of Strongyloides stercoralis were detected in 57.2% (n=4), Opisthorchis felineus eggs (28.6%, n=2) and mixed invasion of Toxocara canis eggs with dead larvae of Strongyloides stercoralis (14.2%, n=1). Conclusion: The presence of helminth eggs (Opisthorchis) indicates soil contamination with faeces from infested people. Thus, there was direct contact between soil and the test samples contaminated with the parasite’s eggs in these settings. Furthermore, dead Strongyloides larvae and Toxocara eggs in the studied samples indicate that the soil was contaminated with the faeces of infested animals. Thus, the samples were taken not from a tree but directly from contaminated soil. Keywords: Parasitic safety, fruit and berry products, Toxocara, roundworms, Strongyloides, helminth eggs and larvae.
INTERDEPARTMENTAL INTERACTION FOR ROAD ACCIDENT CONSEQUENCES ELIMINATION
Authors:   Department of Disaster Medicine and Life Safety, Izhevsk State Medical Academy, Izhevsk, Russian Federation, MELNIKOVA I.S. , SHKATOVA E.YU. ,   Department of Disaster Medicine and Life Safety, Izhevsk State Medical Academy, Izhevsk, Russian Federation
Published: March 2023

Objective: Analysis of cooperation between the Ministry of Emergency Situations (MChS) and Emergency Medical Services (EMS) personnel in the coordination of efforts to eliminate the consequences of road traffic accidents (RTA) in the city of Izhevsk, Udmurtia, Russia. Methods: 206 employees of the MChS of Izhevsk, who participated in road accident consequences elimination in 2018, were questioned. Data were extracted from 5052 MChS statistical forms «Card 1/RTA» from 2011 to 2017. Statistical analysis of the data included the calculation of extensive indicators, the weighted arithmetic mean, the calculation of the z-test, smoothing the time series using a moving average, the calculation of the growth rate using the SPSS 22 and Microsoft Excel 2010 statistical software package. The level of statistical significance was taken as p<0.05. Results: The social survey analysis of the MChS personnel showed that in 80.1% of cases, emergency teams arrived at the accident scene on time. Over the 7-year observation period, according to the statistical forms «Card 1/RTA», in 52.6±3.2% of cases, the ambulance teams arrived at the accident scene after the MChS employees. The questionnaire results on the waiting periods (up to 15 minutes) for emergency teams by the MChS employees match the records data (p>0.05). In 68.5% of cases, one ambulance team attended one victim; in 17.1% and 5.7%, two and three victims, respectively. However, there have been documented cases when one emergency team attended more than 4 casualties of road accidents. Conclusion: This study addressed one of the aspects of interdepartmental relations; however, some issues remain unresolved. In some cases, it was manifested in uncoordinated interactions between the EMS and the MChS: non-simultaneous arrival of representatives of two departments, insufficient number of emergency teams at the accident scene, incoherence between services at the accident scene. Keywords: Ministry of Emergency Situations, ambulance, interagency cooperation, traffic accident, rescue work.
PERSONALISED MEDICINE IN BRONCHIAL ASTHMA: CURRENT CONCEPTS AND PROSPECTS
Authors:   Department of Faculty Pediatrics with Courses in Pediatrics, Neonatology and Simulation Center of IDPO, Bashkir State Medical University, Ufa, Russian Federation, FAYZULLINA R.M. , VIKTOROV V.V. ,   Department of Faculty Pediatrics with Courses in Pediatrics, Neonatology and Simulation Center of IDPO, Bashkir State Medical University, Ufa, Russian Federation, GAFUROVA R.R. ,   Department of Faculty Pediatrics with Courses in Pediatrics, Neonatology and Simulation Center of IDPO, Bashkir State Medical University, Ufa, Russian Federation
Published: March 2023

Bronchial asthma (BA) is today a global medical and socio-economic issue in the health care system. Manifesting in childhood, the disease persists throughout the patient’s life, characterised by a variable clinical course. The periods of remission are combined with the periods of exacerbation and a wide range of symptoms ranging from mild symptoms to severe illness. Following the data of epidemiological studies, BA occupies a leading place among the chronic disorders of the lungs of non-infectious aetiology with increasing the annual prevalence trend. The article presents a literature review on the prospects for a personalised medicine (PM) approach for the group of socially significant, multifactorial diseases, including BA. Implementing PM for asthma patients makes it possible to diagnose and predict the disease even at the preclinical stage. This will reduce mortality, morbidity and disability rates, cut the costs of treatment and rehabilitation of symptomatic patients, and increase the patient’s adaptive capabilities, coping with outdoor environmental and local factors. Keywords: Bronchial asthma, personalised medicine, HealthNet program, P4 medicine concept.
Analisis Nilai Tambah dan Strategi Pengembangan Pengolahan Limbah Batang Tembakau Menjadi Tobacco Xylitol
Authors: Slamet Ahmad Haris Hasanuddin , Setiawan Dani , Mutmainah Dini Nafisatul , Fatinia Lilis Ayu , Damayanti Risma
Published: March 2023

Tembakau merupakan komoditas strategis dan salah satu tanaman perkebunan di Indonesia. Produksi tembakau Indonesia pada tahun 2021 diperkirakan mencapai 261.011 ton. Produksi yang besar menjadikan tembakau sebagai sumber pendapatan negara salah satunya melalui devisa negara. Pengolahan tembakau yang dikenal luas saat ini yaitu pembuatan rokok. Bagian tembakau yang diolah menjadi rokok adalah daun sedangkan batang tembakau tidak diolah dan menjadi limbah. Penanganan limbah batang tembakau saat ini hanya dengan proses pembakaran. Penanganan ini dapat menimbulkan pencemaran asap batang tembakau yang masih mengandung nikotin sehingga memiliki dampak buruk bagi Kesehatan. Kandungan dalam batang tembakau memiliki potensi pemanfaatan limbah batang tembakau sebagai solusi mengatasi limbah batang tembakau dan menjadi produk bernilai tambah tinggi. Peningkatan nilai tambah dapat dilakukan dengan mengolah limbah batang tembakau menjadi xylitol sebagai pemanis alami. Paper ini bertujuan untuk melakukan kajian potensi pengembangan agroindustri olahan limbah batang tembakau. Analisis data yang digunakan yaitu berupa analisis matriks SWOT dan analisis nilai tambah metode Hayami. Hasil studi menunjukkan bahwa olahan limbah batang tembakau menjadi xylitol memiliki potensi untuk memajukan industri tembakau.
Analisis Loyalitas Konsumen Pada J.CO Donuts & Coffee Jember
Authors: Cahyani Zenik Eka , Ambarkahi Ratih Puspitorini Yekti , Gemaputri Ariesia Ayuning , Retnowati Naning , Dhamayanthi Wenny
Published: March 2023

Penelitian ini dilatarbelakangi karena banyaknya perusahaan franchise dengan produk utama yang sejenis yaitu donut dan kopi yang berdiri di Jember, salah satunya ialah J.CO Donuts & Coffee Jember. Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh citra merek, harga, dan kualitas produk terhadap loyalitas konsumen pada J.CO Donuts & Coffee Jember. Populasi dalam penelitian ini ialah seluruh konsumen J.CO Donuts & Coffee Jember dengan pengambilan sampel sebanyak 40 responden. Alat analisis yang digunakan dalam penelitian ini adalah analisis regresi linier berganda dengan bantuan SPSS 23.00. Hasil dari penelitian ini ialah secara serempak variabel citra merek (X1), harga (X2), dan kualitas produk (X3) berpengaruh signifikan terhadap loyalitas konsumen pada J.CO Donuts & Coffee Jember. Secara parsial variabel harga (X2) dan kualitas produk (X3) berpengaruh signifikan terhadap loyalitas konsumen pada J.CO Donuts & Coffee Jember sedagkan variabel citra merek (X1) berpengaruh tidak signifikan terhadap loyalitas konsumen pada J.CO Donuts & Coffee Jember. variabel bebas yang berpengaruh paling dominan terhadap loyalitas konsumen pada J.CO Donuts & Coffee Jember yaitu variabel kualitas produk (X3).
Model Pemasaran untuk Meningkatkan Volume Penjualan Ekspor Udang Vaname (Litopenaeus Vannamei) : Studi Kasus UD. Jumari
Authors: Rivaldi Muhammad Adam , Jamil Muhammad , Supristiwendi  , Mahyuddin Thursina
Published: March 2023

Tujuan dalam penelitian yaitu untuk menganalisis bagaimana strategi pemasaran dan strategi apakah yang paling tepat untuk meningkatkan penjualan ekspor udang vaname (Litopenaeus Vannamei) Pada UD. Jumari Kecamatan Gebang Kabupaten Langkat. Penentuan lokasi penelitian dilakukan secara studi kasus. Desain penelitian dilakukan dengan pendekatan deskriptif kualitatif yang dikuantitatifkan. Pendekatan deskriptif kualitatif ini mengunakan bauran pemasaran (product, price, place, promotion). Analisis data menggunakan analisis SWOT (Strenght, Weakness, Opportunity, Threat), dan analisis QSPM. Hasil penelitian menunjukkan nilai skor IFAS sebesar 2,93 menunjukkan posisi internal yang kuat, nilai skor EFAS sebesar 2,64 menunjukkan bahwa perusahaan merespon peluang dan menghindari ancaman-ancaman yang ada. Pada diagram Cartesius diketahui UD. Jumari berada pada kuadran I dan berada pada jalur yang tepat dengan melakukan strategi agresif. Strategi yang harus diterapkan oleh UD. Jumari adalah mendukung kebijakan pertumbuhan yang agresif (Growth Oriented Strategy).  Pada matriks IE, UD. Jumari terletak pada sel 5, hasilnya perusahaan masuk kedalam fase growth yang berkonsentrasi melalui integrasi horizontal dan stability yaitu tidak ada perubahan profit strategi. Matriks SWOT, perusahaan berada pada kotak SO. Prioritas strategi pemasaran yang diperoleh dari hasil analisis dengan menggunakan matriks QSPM adalah Memanfaatkan kualitas udang dan sertifikasi dari kementerian kelautan dan perikanan Indonesia yang dimiliki oleh UD. Jumari agar dapat memperluas pasar dan menjaga citra yang baik dikalangan konsumen untuk meningkatkan penjualan. Peneliti menyarankan UD. Jumari agar dapat tetap mempertahankan serta meningkatkan kualitas daripada udang UD. Jumari dan memperluas dan mengembangkan akses di pasar internasional maupun lokal agar dapat meningkatkan tingkat penjualan.
Synergism of Tephrosia vogelii and Piper aduncum Based Nanoemulation Against Spodoptera frugiperda
Authors: Nguyá»…n Sang PhÆ°á»›c , Lina Eka Candra , Hidrayani Hidrayani , Busniah Munzir
Published: March 2023

The botanical insecticide nanoemulsion is a pesticide having an oil phase and aqueous phase that spontaneously emulsify and range in size from 20 to 200 nm. Bio-combi extracts frequently contain intricate combinations of active ingredients that may work in concert to increase bioactivity. The goal of the study was to develop the optimal nanoformulation and investigate the physiological effects of a synergistic nanoemulsion made from Tephrosia vogelii leaves and Piper aduncum fruit extracts as a substitute pesticide for Spodoptera frugiperda larvae. Low-energy spontaneous emulsification with a magnetic stirrer was used to create nanoemulsions, which were then subjected to a toxicity and food absorption test. Malvern's Zetasizer Nano (ZN), which was used to analyze the insecticidal nano formulae for PSA, revealed that the particle sizes for the 1:1, 3:1, and 1:5 ratios were 204 nm, 4724 nm, and 97 nm, respectively. Only the 1:5 formula, which is classified as a nanoparticle, met the standards for a nanoemulsion and produced S. frugiperda mortality of 82.34% at a concentration of 0.56%, and the LC25, LC50, and LC95 values were 0.1, 0.22, and 1.59%, respectively. The analyzable results demonstrated that the mixed nanoemulsion was additive at the LC50 value was 0.95 while the LC95 value was 0.70%, meaning only marginally synergistic
PENGELOLAAN BRANDING PERUSAHAAN DI MEDIA SOSIAL MELALUI PENDEKATAN CONTENT MARKETING
Authors: Siregar Falaah Saputra , Purnama Hadi , Parsono Slamet
Published: March 2023

As a newly established company, Etapasbar is aiming to further increasing their brand awareness and branding to customers and Pasar Baru Bandung Merchant. Etapasbar chose to use instagram @etalasepasarbaru as the main social media to communicate with the audience. This research is done to find out how do Etapasbar manage company branding by using content marketing approach in Instagram based on case study of Bahenol, Balantik, and Beja ti Pasbar. Bahenol, Balantik, and Beja ti Pasbar are three main content programs created for fulfilling the need of brand awareness and branding. This research object is the strategic and management of branding in Etapasbar. Data is collected by using interview and observation. Researcher will analyze the three main content programs based on observation then researcher will ask for futher indepth information of the programs. Discussion will be breakdown into three section, flow and strategic management of content, effort of increasing brand awreness, and building branding. This research resulting in the strategic formulation that is used by Etapasbar based on market segmentation, the attempt of increasing brand awareness is done by using attribute that is shown in the content in Instagram, Etapasbar branding is created and formed by satisfaction of customer and registered merchant at Etapasbar.

Keywords: content marketing, corporate branding, erapasbar, social media
"And This is What I Saw”: (Un)Natural Waste in Cathy Park Hong’s “Fable of the Last Untouched Town”
Authors:   Universidade da Coruña (España), Praga Martín
Published: March 2023

At its most philosophical, poetry can help us imagine alternative realities. In “Fable of the Last Untouched Town,” Cathy Park Hong manages to complicate current notions of nature by way of an unusual form of futuristic waste. Through the analysis of the poem, this article aims, on the one hand, to show how works of poetry can reflect and denounce some of the many ugly aspects of reality. Particularly, Hong can be said to draw in her poem an allegory of the pressing issue of e-waste. On the other, I intend to highlight how poetic imaginations can shake certain assumptions regarding those contemporary conceptions of nature and problematize the humanistic tendency in new materialisms and object-oriented theories. Indeed, an understanding of waste as the threshold which separates us from Nature might better equip us when facing the imminent change of paradigm that looms over our understanding of our place in the world.
“Gardening in Eden”: Wasted Lives, or Detoxic Identities in Gail AndersonDargatz’s Turtle Valley and Barbara Kingsolver’s Prodigal Summer
Authors:   Universidad de La Laguna (España), Carmona Rodríguez Pedro Miguel
Published: March 2023

This paper analyzes the inflection of a border-crossing ecological concern on the regional cultures of settlement through Gail Anderson-Dargatz’s Turtle Valley (2007) and Barbara Kingsolver’s Prodigal Summer (2000). Their engagement with the contingent position of the farmers in the British Columbia Shuswap region, and the southern Appalachian Zebulon County resituates the self. The struggle for production is substituted by a revisionist attitude that relocates (wo)men and nature in a sustainable coexistence that approaches the human species and others. The ecological awareness of these novels uses a postindustrial landscape where human bodies and lives exhibit the malaise inflicted on the environment; they increasingly become waste(d) and toxic, and their habitat becomes a threat, also materialized in (post)natural catastrophes impelling the relocation of human communities, or business reinvention. The human wastification of Eden is instrumental to launch a revision that detoxifies identity thanks to a remodeled bond with nature.
Waste and Textual Expenditure in William T. Vollmann’s Imperial
Authors:   Universidade da Coruña (España), Liste José
Published: March 2023

As a consciously transgeneric text, William T. Vollmann’s Imperial explores the delineated realities of the US-Mexico border region by zeroing in geographically, culturally, historically, even literarily via his own self-reflexive writing on the border county named Imperial. Vollmann’s intense focus on one specific area produces a sort of Pynchonian excess, melded with minimally precise “delineations,” that seeks a never quite settled ethical and aesthetic resolution of a reality where the border region is both literally divisive and ceaselessly porous. Such literal and literary ‘mapping’ articulates ambivalent strategies of material and textual wastefulness, it tracks toxic waste disposal and reckless waste abandonment, and it brings to light the conscious, exploitative wasting of human bodies and marginalized communities. But can a literary work of nonfiction invert the very wastefulness of waste through its own textual excesses? How does one confront an empire of waste through the very strategies of wastefulness?
On the Uses of Waste
Authors:   Universidade de Santiago de Compostela (España), Villamarín-Freire Sara
Published: March 2023

For the past few years, waste has become an increasingly popular topic among literary scholars. The sheer volume of areas of knowledge involved in this highly interdisciplinary field has been somehow blurred as the labels “Waste Studies” and “Waste Theory” gained traction. Nevertheless, upon closer inspection those terms crumble easily. What is “Waste Theory”? What attempts, if any, have been made to agglutinate these disparage fields and their corresponding contributions into a cohesive discipline of its own? This paper aims to shed light on these questions by reviewing some of the most referenced works and authors within the burgeoning waste scholarship. Likewise, it seeks to critically examine whether it would be possible–and productive–to elaborate a general theory of waste.
The Kinetic Chain Has a Brain: Could Adding Cognitive Demands in Lower Limb Injury Prevention Programs Improve Outcomes?
Authors: Huddleston Wendy E. , Probasco Mark O. , Reyes Michaela A.
Published: March 2023

SYNOPSIS: The most effective lower limb injury prevention programs include strength training, balance exercises, and instructions on how to land safely from a jump or hop. Yet, the programs are not 100% effective—lower extremity noncontact injuries continue to be a significant problem. We suggest that adding cognitive training to motor tasks that currently comprise current lower limb injury prevention programs might help clinicians, athletes, and coaches continue to make inroads into preventing knee injuries. We ground our hypotheses in robust findings from cognitive neuroscience and rehabilitation, suggesting that when task demands exceed the attentional capacity of an individual, the risk for noncontact lower extremity injuries increases. In this editorial, we explain the concepts of attentional capacity and attentional demands, and the interplay of the two in sport, to justify including cognitive tasks to injury prevention programs to improve outcomes. J Orthop Sports Phys Ther 2023;53(4):159–161. doi:10.2519/jospt.2023.11403
Efficacy of fixed duration multidrug therapy for the treatment of multibacillary leprosy: A prospective observational study from Northern India
Authors: Singh Itu , Ahuja Madhvi , Lavania Mallika , Pathak Vinay K , Turankar Ravindra P , Singh Vikram , Sengupta Utpal , Das Loretta , Kumar Archana , Saini Geeta B
Published: March 2023

Background:

In endemic regions of several countries, the prevalence of leprosy has not come down to the level of elimination. On the contrary, new cases are being detected in large numbers. Clinically, it is frequently noted that despite completion of multibacillary multidrug therapy for 12 months, the lesions remain active, especially in cases with high bacteriological indices.

Aim:

The present study focused on finding out the viable number of Mycobacterium leprae during the 12-month regimen of multibacillary multidrug therapy, at six and 12 months intervals and, attempting to determine their role in disease transmission.

Methods:

Seventy eight cases of multibacillary leprosy cases were recruited from leprosy patients registered at The Leprosy Mission hospitals at Shahdara (Delhi), Naini (Uttar Pradesh) and Champa (Chhattisgarh), respectively. Slit skin smears were collected from these patients which were transported to the laboratory for further processing. Ribonucleic acid was extracted by TRIzol method. Total Ribonucleic acid was used for real-time reverse transcription-polymerase chain reaction (two-step reactions). A standard sample with a known copy number was run along with unknown samples for a reverse transcription-polymerase chain reaction. Patients were further assessed for their clinical and molecular parameters during 6th month and 12th month of therapy.

Results:

All 78 new cases showed the presence of a viable load of bacilli at the time of recruitment, but we were able to follow up only on 36 of these patients for one year. Among these, using three different genes, 20/36 for esxA, 22/36 for hsp18 and 24/36 for 16S rRNA cases showed viability of M. leprae at the time of completion of 12 months of multidrug therapy treatment. All these positive patients were histopathologically active and had bacillary indexes ranging between 3+ and 4+. Patients with a high copy number of the Mycobacterium leprae gene, even after completion of treatment as per WHO recommended fixed-dose multidrug therapy, indicated the presence of live bacilli.

Limitations:

Follow up for one year was difficult, especially in Delhi because of the migratory nature of the population. Patients who defaulted for scheduled sampling were not included in the study.

Conclusion:

The presence of a viable load of bacilli even after completion of therapy may be one of the reasons for relapse and continued transmission of leprosy in the community.
Imaging of the Unilateral Swollen Painful Lower Leg: Deep Vein Thrombosis Mimics
Authors: Paramesparan K. , Iqbal Aamer , Shah Amit , Botchu Rajesh
Published: March 2023

The presentation of unilateral leg swelling is commonly encountered clinical practice, with deep vein thrombosis (DVT) often raised as the main diagnosis. Not infrequently, and at times unexpectedly, a different pathology can be encountered. It is important to be aware of other causes of the unilateral swollen leg to avoid unnecessary anticoagulation and potential missed diagnosis. This article provides a systematic approach, with a review of the imaging characteristics, of the most common etiologies that can cause unilateral leg swelling mimicking a DVT.
Magnetic Resonance Imaging of Complications in Total Knee Arthroplasty: A Pictorial Essay
Authors: Pilania Khushboo , Jankharia Bhavin
Published: March 2023

With the ever-increasing number of total knee replacement, the demand for early diagnosis of post arthroplasty complications has increased as well. The various complications associated with total knee replacement include bursitis, tendinitis, periprosthetic fracture, infection, instability, malalignment, loosening, prosthesis fracture, osteolysis, soft tissue impingement, and extensor mechanism problems. Radiographs and nuclear imaging, earlier the mainstays for evaluation of post arthroplasty knee, have vast limitations, especially in evaluating the soft tissue details which account for the symptoms in a significant number of patients. Magnetic resonance with special modifications, i.e. metal artifact reduction sequences, is of immense help in a detailed evaluation of these soft tissue complications and is advisable in all patients where the cause cannot be determined on plain radiographs.
Efficacy and tolerance profile of risperidone use in people with autism spectrum disorder in a clinic in Santarém, Pará, Brazil. A retrospective study
Authors: da Silva João Ferreira , Honorato Marcos Manoel , Cremaschi Renata Maria de Carvalho , Coelho Fernando Morgadinho Santos
Published: March 2023

Objectives:

This study aimed to obtain the profile of efficacy and tolerance of risperidone in the treatment of people with autism spectrum disorder.

Materials and Methods:

This research was a cross-sectional and retrospective study. The medical records of 100 patients diagnosed with ASD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) were analyzed and measures of central tendency and correlation between variables such as gender, age at diagnosis, symptoms, daily dose, comorbidities, polytherapy, adverse drug effects, and outcome (improvement, worsening, and drug discontinuation) were calculated using Pearson’s R test with a level of statistical significance P < 0.05.

Results:

The male gender was the most affected, corresponding to 80% of the participants. The mean age at diagnosis was 6.88 ± 6.24 and the mean dose was 1.89 ± 1.68 mg/day. The use of risperidone for patients with aggressiveness, hyperactivity, insomnia, or self-harm improved in 76% of patients and adverse effects were reported in 27% of cases. The presence of self-harm implied lower chances of improvement (P = 0.05/r = −0.20). Adverse effects were strong predictors of discontinuation (P = 0.01/r = 0.39), and epileptic patients were more likely to have them (P = 0.02/r = 0.20). Male gender was associated with dosages lower than 2 mg/day (P = 0.05/r = 0.23).

Conclusion:

Risperidone is a good option in the management of secondary symptoms of ASD, generally requiring low doses and presenting an acceptable profile of adverse effects. The age of diagnosis does not affect the drug’s efficiency, but it can make the management of ASD difficult.
Impact of COVID-19 on abused pregnant and lactating women receiving reproductive and child health services at tertiary care hospital, New Delhi, India
Authors: Mahapatro Meerambika , Roy Sudeshna , Nayar Poonam , Panchkaran Suruchi , Jadhav Ashwini
Published: March 2023

Objectives:

The worldwide healthcare system has been overwhelmed by the COVID-19 pandemic’s emergence and increasing intensification. As a result, essential and routine reproductive child health (RCH) services have been severely harmed. The paper tries to find out the impact of COVID-19 on abused pregnant and lactating women receiving routine RCH services at a tertiary care hospital in New Delhi, India.

Material and Methods:

It is an ethnography study undertaken with 150 abused pregnant and lactating women receiving RCH services at Lok Nayak Hospital, New Delhi. They were called and followed up with over the phone from March 23 to May 22, 2020. The findings revealed that there has been an increase in the incidences of domestic violence.

Results:

The main reasons for difficulty reported by the women were inadequate information on changes in antenatal care at the hospital, lockdown restrictions on travel from one facility to another, a breakdown in communication with the healthcare team, and health system barriers. As a result, it exacerbated pregnant and lactating women’s anxiety and distress. During the crisis, these negative consequences on pregnancy outcomes and maternal health must be taken into account immediately.

Conclusion:

Instead of women seeking information and services, the health system can make normal public health services more accessible to women by offering proactive tailored information over the phone on where to go, when to go, what precautions to take, and so on. For better RCH services to women during pandemics, the government must design a health management system that balances routine care with emergency treatment.
Monitoring the invariability of medical images during transmission over communication channels
Authors:   The Bonch-Bruevich Saint Petersburg State University of Telecommunications, Saint Petersburg, Russian Federation, Gerling E.Y. , Akhrameeva K.A. ,   The Bonch-Bruevich Saint Petersburg State University of Telecommunications, Saint Petersburg, Russian Federation
Published: March 2023

Relevance. Modern methods of ophthalmic medical examinations, for example, ultrasound biomicroscopy, optical coherence tomography, axial MR tomography, and so on, allow you to save results, medical images in electronic form. The obtained image can be stored and transmitted via communication channels, which allows doctors to easily exchange information about the patient, since all tests are now in a single electronic patient card, as well as conduct long-distance consultations. Accurate diagnosis requires that ophthalmic medical images be protected from alteration, both intentional and accidental, when stored and transmitted over communication channels. Purpose. The goal of this work is to investigate the possibility of using modern digital watermark methods to control the integrity and immutability of stored and transmitted ophthalmic medical images. Material and methods. This article uses the results of a study of accurate authentication algorithms conducted using specially written software that allows you to attach and extract a digital watermark. Results. The possibility of using existing algorithms for embedding digital watermarks in ophthalmic medical images to control the absence of distortion during their storage and transmission has been investigated. Here is an example of accurate snapshot authentication using a digital watermark. Conclusion. The article considers the possibility of accurate authentication of ophthalmic medical images to control their invariability. State-of-the-art digital watermarking algorithms allow for monitoring the immutability of ophthalmic medical images during storage and transmission. Keywords: digital watermark, ophthalmic medical snapshot, accurate authentication, immutability, embedding algorithm
Modern possibilities for optimizing the calculation of intraocular lens optical power using deep machine learning capabilities
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd Branch, Volgograd, Russian Federation, Vinogradov A.R. , Dzhashi B.G. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd Branch, Volgograd, Russian Federation, Yuferov O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd Branch, Volgograd, Russian Federation, Balalin S.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd Branch, Volgograd, Russian Federation, Tarapatina E.S. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd Branch, Volgograd, Russian Federation
Published: March 2023

Purpose. To develop optimized machine learning technology to improve the accuracy of intraocular lens (IOL) optical power calculation. Material and methods. Publications in Russian and foreign media fort he last 5 years which report about using artificial intelligence to improve the accuracy of IOL optical power calculation were analyzed. Results. Two different approaches using artificial intelligence in optimization of IOL calculation are known: firstly, modification of existing theoretical formulas and secondly, based only on analysis of patients' database before and after IOL implantation. Each approach has its advantages and disadvantages. The absence of an «ideal» formula forces surgeons to analyze incoming patient data and make corrections to the results obtained based on their own experience when calculating IOLs. In the clinic of the Volgograd branch of the S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery» developed a design project for the LensCalc software application and algorithms of its step-by-step operation. Conclusion. The development of a software application based on artificial intelligence is a rather labor-intensive process that requires processing a large amount of data, using formulas and algorithms with obtaining the final result, as well as subsequent training, optimization, and improving the quality of its work. The LensCalc software application is based on the use of artificial intelligence algorithms to select the formula for calculating the optical power of the IOL that is most suitable in a particular clinical situation. Keywords: IOL calculation, artificial intelligence